SGTCid condition conc unit YMR111C|YMR111C.score YMR111C|YMR111C.strain.pval YMR111C|YMR111C.strain.significant YMR111C|YMR111C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_58 0957-0393 9 µM 5.47139309119319 3.20907698202084e-10 yes 1 2.23255833989458e-08 244 6997992
SGTC_1270 0831-1170 17.3 µM 3.76974193546757 1.03954871201349e-05 yes 2 8.17082155335434e-05 14 6764716
SGTC_1176 0848-0131 83.3 µM 3.59644878689199 2.45018595111425e-05 yes 3 0.000161295529260881 30 6769040
SGTC_807 1315-0151 48 µM 3.26869836378887 0.000112200727073067 yes 4 0.000540217072000755 52 4011080
SGTC_2329 6138490 200 µM 3.26653219096732 0.000113285591294657 yes 5 0.000544367144364246 64 720019
SGTC_798 1287-0182 476 µM 3.19116347151522 0.0001577763199345 yes 6 0.000708505404136776 52 1649755
SGTC_1183 1254-0324 198 µM 2.925145326519 0.000480891959993414 yes 7 0.00172147697474796 62 5799357
SGTC_886 0866-0150 153 µM 2.90264630982861 0.000526367801032911 yes 8 0.00185012136300676 70 271463
SGTC_2358 9037157 4 µM 2.88312477512685 0.00056901606849063 yes 9 0.00196875719514075 81 2388925
SGTC_2045 5106652 78.05 µM 2.75378085923836 0.00094255625541322 yes 10 0.00294555995703678 63 673349
SGTC_739 1486-1183 203 µM 2.70417231241833 0.00113781809082974 no 11 0.00342373851833634 70 4346692
SGTC_2362 9071156 126 µM 2.69472496144947 0.00117896223154633 no 12 0.00352233770727417 73 653133
SGTC_2103 5378138 10 µM 2.6830881256729 0.00123151273973228 no 13 0.00364728828276915 90 244142
SGTC_2754 granisetron 64.02 µM 2.59136477748067 0.0017269284024471 no 14 0.00477980510745251 131 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1246 0422-0085 105 µM 2.55899018942034 0.00194118527848569 no 15 0.00524883519419598 136 264295
SGTC_2638 epoxomicin 18 µM 2.5586488203432 0.00194356779662173 no 16 0.00525399163767749 103 9915668 A protesome inhibitor.
SGTC_810 3825-7150 143 µM 2.54157606102786 0.00206616657307103 no 17 0.00551769662846358 79 22330411 YGL099W LSG1
SGTC_2625 euphol 100 µM 2.5163101946207 0.00226050294769803 no 18 0.00592953785777762 139 6708538 A triterpene alcohol.
SGTC_2435 5706476 10.6 µM 2.4594239283846 0.00275997719198693 no 19 0.00695800929430601 129 5725375
SGTC_2640 pentamidine 10.38 µM 2.44693503891863 0.00288215976226686 no 20 0.00720384021218349 151 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1525 8-methoxypsoralen 92.5 µM 2.40651060580016 0.00331180317085711 no 21 0.00805286818476342 152 4114 Related to psoralen; DNA damaging agent.
SGTC_716 1683-5115 658 µM 2.39955486228353 0.00339128319875565 no 22 0.00820750990114678 134 723597
SGTC_2602 kawain 100 µM 2.39223792711307 0.00347673655024561 no 23 0.00837299135062235 153 5369129
SGTC_1351 1496-0003 46.5 µM 2.38828961165663 0.00352364730512879 no 24 0.00846349845825014 124 3891978
SGTC_1276 0871-0068 94.2 µM 2.37785399633093 0.00365038320683883 no 25 0.00870685968559922 117 3414906
SGTC_2639 lactacystin 53 µM 2.34793208729241 0.00403675390343802 no 26 0.00943898149216095 152 3870 A proteasome inhibitor.
SGTC_2634 4'-methoxyflavone 100 µM 2.34768462966608 0.00404009638264583 no 27 0.00944525414142041 147 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1988 st071872 53.4 µM 2.33835915008941 0.00416787820825798 no 28 0.00968431248068486 108 16414116
SGTC_3021 9087658 49.47 µM 2.33136394733527 0.00426609020166843 no 29 0.00986708844961317 66 25237042
SGTC_2751 anetholtrithion 17.25 µM 2.31196902176032 0.00454930272419063 no 30 0.0103896952590031 161 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1830 st055982 50.3 µM 2.25357531806442 0.00550600708704601 no 31 0.0121114487636761 154 455313 An antimicrobial agent.
SGTC_1338 1486-1223 76 µM 2.24999067140037 0.00557017670591505 no 32 0.0122247687446564 161 3444526
SGTC_1251 0490-5699 265 µM 2.21921950152719 0.00614891701002032 no 33 0.0132358974819718 200 3883818
SGTC_1832 st054113 55 µM 2.21205104941518 0.00629116004903706 no 34 0.013481568920097 114 1251267
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 2.19559961926145 0.00662867130155291 no 35 0.0140603067629848 170 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 2.18895549384701 0.00676945498524468 no 36 0.0143000375017966 181 94937 An inhibitor of serotonin biosynthesis.
SGTC_373 0844-0104 25.9 µM 2.18754846990481 0.0067996054447613 no 37 0.0143512544493748 216 5375804
SGTC_2491 paeonol 100 µM 2.16668886670278 0.00726071753966901 no 38 0.0151292930409861 117 11092 Increases levels of cortical cytochrome oxidase.
SGTC_367 0335-0881 7.1 µM 2.16242723926527 0.00735824518743268 no 39 0.0152926299292523 244 23828853
SGTC_2430 5571206 200 µM 2.16135386868903 0.00738299065088651 no 40 0.0153340073486597 217 1731771
SGTC_2230 bromochlorosalicylanilide 954.5 nM 2.14415361962833 0.00778964902490832 no 41 0.0160102899701619 89 77254
SGTC_1924 st058459 75.1 µM 2.13820348128482 0.00793484508125616 no 42 0.0162501159824316 150 688683
SGTC_1382 3002-2117 298 µM 2.13139701665822 0.00810385112383855 no 43 0.0165282242256791 165 1497314
SGTC_1630 st005209 31.3 µM 2.09879458261465 0.00895798833228071 no 44 0.0179175063028845 228 3367314
SGTC_2576 guaiol 23.12 µM 2.09877360237886 0.00895856245420259 no 45 0.0179184314476733 210 227829
SGTC_2288 7946289 167.31 µM 2.09167626198822 0.00915463993403728 no 46 0.0182337426905219 222 1246052
SGTC_2114 5491910 81.25 µM 2.08020686010122 0.00947944910437518 no 47 0.0187532816487772 166 2849228
SGTC_1938 st074717 56.4 µM 2.06847452657427 0.00982208666751132 no 48 0.0192977117774779 146 17250979
SGTC_598 3937-0236 20.2 µM 2.06140435349906 0.0100337500168802 no 49 0.01963223993645 232 1379313
SGTC_803 4488-1585 147 µM 2.06077990379257 0.01005263440959 no 50 0.0196620212736973 171 747204
SGTC_394 menadione 8.33 µM 2.04821633952545 0.010439222040855 no 51 0.0202694030583871 210 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3018 9082602 49.47 µM 2.03368066058274 0.0109026038847268 no 52 0.0209919016470882 219 17332089
SGTC_2794 7785382 27.27 µM 2.02736941552406 0.011109308981213 no 53 0.0213123236660231 272 2205081
SGTC_1799 st045822 46.1415 µM 2.02542159904502 0.0111737880645216 no 54 0.0214120457195826 183 3674992
SGTC_1420 4'-methoxyflavone 42 µM 2.01968108587934 0.0113657139541268 no 55 0.0217082391230594 173 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1343 1487-0095 224 µM 2.0186378513799 0.0114008989144966 no 56 0.0217624369268881 177 4560101 YGL055W OLE1
SGTC_2711 st079103 59.1 µM 2.00662159682697 0.0118130406210305 no 57 0.0223949849701039 165 54693780
SGTC_41 0478-0632 82.643 µM 1.98698577052947 0.0125143603543132 no 58 0.0234619868670897 268 3750424
SGTC_2143 5623677 140.463 µM 1.96564904249983 0.013317024074764 no 59 0.0246695824344038 156 5375313
SGTC_1619 st003326 88.7 µM 1.96321660312731 0.0134112937603642 no 60 0.0248105054713036 181 2849032
SGTC_2693 st077581 40.7 µM 1.95301225566246 0.0138130708726855 no 61 0.0254090714952914 313 25238761
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.94845422595691 0.0139958626958364 no 62 0.0256803184109299 313 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2492 derrusnin 100 µM 1.93726024998703 0.014453648574373 no 63 0.0263567693225046 158 1715307 Part of coumarin class of compounds.
SGTC_103 0844-0104 51.839 µM 1.92790574783415 0.0148460384001697 no 64 0.0269334253415811 412 5375804
SGTC_1090 efavirenz 20.7 µM 1.91270687080857 0.0155031128819187 no 65 0.0278927945541781 237 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1229 0139-0193 12.2 µM 1.90380346531844 0.0158994987895289 no 66 0.0284678925305141 260 3090752
SGTC_1177 0983-0204 23.6 µM 1.9010227387859 0.0160250661711 no 67 0.0286495171488325 232 766818
SGTC_2363 9053361 176 µM 1.88384818425725 0.0168195933769984 no 68 0.0297927568824244 285 6469797 YMR079W SEC14
SGTC_335 4077-0256 27.6 µM 1.88260090100124 0.0168785850821418 no 69 0.0298772370972383 267 3121989
SGTC_1346 1488-2224 62.4 µM 1.88110550330608 0.0169495447922095 no 70 0.029978784268665 241 3722427
SGTC_813 k007-0158 173 µM 1.8766652764971 0.017161747623882 no 71 0.0302819922958646 314 6523916
SGTC_2046 4110841 106 µM 1.86579473195091 0.0176908647701103 no 72 0.0310350448316965 240 44119630 YMR134W ERG29
SGTC_1115 galangin 695.678 nM 1.86489090362347 0.0177354782586956 no 73 0.0310983488670224 281 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2447 5741742 33.78 µM 1.86303625993265 0.0178273251964801 no 74 0.0312285824435151 279 1776504
SGTC_1688 st021091 57.6 µM 1.86162242499909 0.0178976143653094 no 75 0.0313281650469358 209 3656366
SGTC_57 miconazole 162.5 nM 1.84112280183556 0.0189436126567075 no 76 0.0328017824533127 257 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1570 verbenone 133 µM 1.83972370635192 0.0190168594744184 no 77 0.0329044056512649 257 29025 A natural terpanoid with antifungal properties.
SGTC_1309 pyrazolanthrone 13.4 µM 1.83021228923719 0.0195212222938477 no 78 0.0336091004296014 286 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_161 4065-0411 162.148 µM 1.82186480137828 0.0199731827250176 no 79 0.0342377511300724 359 1906281 YLR208W SEC13
SGTC_916 4466-0038 42 nM 1.81041356380365 0.0206076088313567 no 80 0.0351158387182534 402 5722064 YGL116W CDC20
SGTC_376 3970-0862 59.1 µM 1.79988796046384 0.0212057279937346 no 81 0.035939165544028 289 3135186
SGTC_558 k064-0027 21.3 µM 1.79608690615979 0.0214253023032331 no 82 0.0362403482753667 292 5088526
SGTC_773 4358-1457 44.6 µM 1.79436905773382 0.0215251655714998 no 83 0.036377141141839 343 1186886
SGTC_1008 4106-0037 6 µM 1.79366680113766 0.0215661028214978 no 84 0.0364331836347879 255 2905394
SGTC_2407 paclitaxel 400 µM 1.79203589279969 0.0216614286684831 no 85 0.0365636083463241 337 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_169 k015-0017 16.025 µM 1.79135182540563 0.0217015179437858 no 86 0.0366184272180712 255 1840002
SGTC_687 k029-0044 34.9 µM 1.77846246055689 0.0224686863439875 no 87 0.0376639660535158 279 5829338
SGTC_1264 0783-0040 158 µM 1.77811965156608 0.0224893984547652 no 88 0.0376921027697582 279 2855798
SGTC_610 4215-0184 155 µM 1.77326686304682 0.0227843294507013 no 89 0.0380922486089271 309 5605015
SGTC_2479 5617353 43.85 µM 1.76861804444748 0.0230699140857347 no 90 0.0384788187019571 316 2731746
SGTC_2246 7293507 91.5585 µM 1.76255370013721 0.0234469824078857 no 91 0.0389878959045569 321 887656
SGTC_1779 st039427 55 µM 1.75505050911376 0.0239206792448992 no 92 0.0396253342979405 363 1124498
SGTC_466 geldanamycin 89.2 µM 1.75409097460599 0.0239818333653346 no 93 0.0397074599635469 189 5288382 HSP90 inhibitor.
SGTC_2757 clomiphene 4.22 µM 1.75249170042634 0.024084052039753 no 94 0.0398446478744287 351 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_112 phenothiazine 287.218 µM 1.74242060366003 0.0247361969693223 no 95 0.0407174366183011 283 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1138 3761-0006 1.03 µM 1.73755136305914 0.0250567746778704 no 96 0.0411449480925938 246 12061087
SGTC_2989 9073649 71.4286 µM 1.7358784739895 0.0251677139243767 no 97 0.0412926623538319 412 21367202
SGTC_2361 9034121 116 µM 1.73175483591883 0.0254429359781006 no 98 0.041658611314237 303 6496917
SGTC_996 3970-0799 1.8 µM 1.73012819634146 0.0255521931533637 no 99 0.0418036867679518 473 6615648 YGL040C HEM2
SGTC_1012 4112-3522 18 µM 1.72858588808228 0.025656148574263 no 100 0.0419416185482406 317 3112398
SGTC_734 2023-0417 80 µM 1.72375515985634 0.0259840453921661 no 101 0.0423760262766536 330 3935732
SGTC_1261 0712-0010 12.7 µM 1.72266321805959 0.026058647234621 no 102 0.0424747227747359 355 2840123
SGTC_1795 st049545 62.3 µM 1.71878201323174 0.0263252639903424 no 103 0.0428270359366526 286 5291882
SGTC_135 0933-0004 26.348 µM 1.71570137025277 0.0265385064853804 no 104 0.0431083569284973 324 21230617 YGL099W LSG1
SGTC_2282 7944268 200 µM 1.71132647194937 0.026843815918742 no 105 0.0435104311030926 369 2970414
SGTC_503 tyrphostin 8 294 µM 1.70817977554226 0.0270652218901922 no 106 0.0438014949970786 345 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1739 st037196 92.5 µM 1.708002111554 0.027077767894929 no 107 0.0438179753377081 322 612214
SGTC_2692 st077426 47.7 µM 1.70681558835462 0.0271616804751366 no 108 0.0439281670532319 333 25238571
SGTC_1989 st071868 50.2 µM 1.70468302597681 0.0273130436755626 no 109 0.0441267786235184 329 16414057
SGTC_766 1391-0721 126 µM 1.69960053181668 0.027676622838435 no 110 0.0446030451311996 323 1020919 YIL115C NUP159
SGTC_746 1095-0025 46.6 µM 1.69485262487358 0.0280199023846724 no 111 0.0450516907733349 328 6749286
SGTC_2792 7535235 81.82 µM 1.68569979529353 0.0286916719269331 no 112 0.0459268181682106 322 1281891
SGTC_2860 9025725 38.96 µM 1.68332435508462 0.0288681892877169 no 113 0.0461561590545899 291 40546248
SGTC_229 benomyl 22.8748 µM 1.68253244682155 0.0289272357203297 no 114 0.0462328192852605 362 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2550 chrysin dimethyl ether 71.87 µM 1.67994399484147 0.0291209371158567 no 115 0.0464841064289538 211 88881 An O-methylated flavonoid and antioxidant.
SGTC_1125 tnp00248 1.32998 µM 1.67089637393814 0.0298064817030543 no 116 0.0473710739381051 445 24207736
SGTC_185 k048-0037 25.491 µM 1.67048007721163 0.0298383442869845 no 117 0.0474122089733344 323 6827589
SGTC_152 4469-0003 551.229 µM 1.66663051206424 0.0301343236589726 no 118 0.0477939489375793 314 697280
SGTC_458 nppb 133 µM 1.66644220942564 0.0301488637980055 no 119 0.0478126848137358 286 4549 A chloride channel blocker.
SGTC_56 0957-0365 83.25 µM 1.66074781840539 0.0305913215526968 no 120 0.0483820526052296 377 6752360
SGTC_217 ketoconazole 989 nM 1.6604194750005 0.030616997175015 no 121 0.0484150474878607 348 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3042 9091578 49.47 µM 1.6572942715227 0.0308622746450104 no 122 0.0487299974543486 252 25236497
SGTC_1644 st010134 20.9 µM 1.65697670819961 0.0308872889626662 no 123 0.048762092115579 302 3818134
SGTC_2870 9038528 12.99 µM 1.64836698633394 0.0315718935447891 no 124 0.0496386931693407 315 6463316
SGTC_2627 acetyl isogambogic acid 100 µM 1.63565302928894 0.0326057408248993 no 125 0.05095611257573 342 6857789 A caspase activator and apoptosis inducer.
SGTC_477 mead ethanolamide 10 µM 1.62902969299555 0.033155289204389 no 126 0.0516533666316167 185 16061185
SGTC_1101 ebselen 5.29 µM 1.62707438884311 0.0333189749625603 no 127 0.0518606498458329 363 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1946 st076057 65.1 µM 1.62515410464124 0.0334803762247534 no 128 0.0520648634292273 219 953009
SGTC_2096 5468907 200 µM 1.61496558387364 0.034347529989156 no 129 0.0531590740572093 346 759785
SGTC_3034 9090421 49.47 µM 1.6085643429804 0.0349017258624628 no 130 0.0538558181486736 320 17173761
SGTC_2563 tomatine 8.54 µM 1.60432683083496 0.0352726161920409 no 131 0.0543210149549952 447 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1379 2144-0755 36.5 µM 1.60305409847579 0.0353846419577727 no 132 0.0544613554184168 401 5392327
SGTC_2346 9031566 143.75 µM 1.59397757465666 0.0361920431388596 no 133 0.0554705288846026 336 4771086
SGTC_3343 9148379 18.9835 µM 1.591780406744 0.0363897430461911 no 134 0.0557170270458777 362 1955036
SGTC_2308 7584454 197.62 µM 1.58822846976333 0.0367112129728529 no 135 0.0561173427816938 429 893577
SGTC_1791 st048313 56.1 µM 1.58727502932177 0.036797898920783 no 136 0.0562251840788311 322 1204976
SGTC_2667 digitoxin 100 µM 1.58372713056939 0.0371219421778857 no 137 0.0566279140255787 258 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1383 3049-0032 20.7 µM 1.58057210568505 0.0374120582131469 no 138 0.0569879539928197 396 712864
SGTC_1948 st076329 66.6 µM 1.57926268523846 0.0375330067358162 no 139 0.057137908505088 349 24208413
SGTC_2752 diclazuril 33.15 µM 1.5711240548983 0.0382919333924345 no 140 0.0580769180651061 557 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1561 5-methoxyflavone 52.9 µM 1.56993222655248 0.0384041143936166 no 141 0.0582154396367245 284 94525
SGTC_2101 5377231 179.231 µM 1.56832796382758 0.0385555386940377 no 142 0.058402306530305 341 2844213
SGTC_1755 st041960 45.185 µM 1.5468141878121 0.0406335991128358 no 143 0.0609540290106288 383 2257073
SGTC_780 0109-0199 192 µM 1.54567094858048 0.0407465226217931 no 144 0.0610920284256395 429 610414
SGTC_2020 4017018 200 µM 1.54341035155486 0.0409705627854884 no 145 0.0613656218303807 393 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1079 idarubicin 2.36 µM 1.53461254533531 0.0418520121881835 no 146 0.0624395146100484 357 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1219 1469-0211 33.1 µM 1.53371826668118 0.0419424629991308 no 147 0.0625494889632257 368 6822282
SGTC_3342 9147791 14.508 µM 1.52909758203916 0.0424123414147927 no 148 0.0631201273506875 392 1838168
SGTC_1973 st070275 50.2 µM 1.52467412948583 0.0428661435045679 no 149 0.0636701987764452 373 17118334
SGTC_2474 5321570 43.32 µM 1.51203289260743 0.0441846706708055 no 150 0.0652627475013516 382 2841384
SGTC_697 0508-1955 564 µM 1.51173616873067 0.0442160084209788 no 151 0.0653004967681502 456 6243113
SGTC_2107 5363541 170.161 µM 1.49804219413583 0.0456818634311131 no 152 0.0670611441106411 433 244052
SGTC_1507 4075-3230 155 µM 1.49531804015286 0.0459780747586374 no 153 0.0674157295595697 356 659771
SGTC_3340 9146634 11.102 µM 1.48994337659543 0.0465670144435248 no 154 0.0681195624708522 420 4907387
SGTC_180 1486-1293 102.781 µM 1.48988296931354 0.0465736679371694 no 155 0.0681275051488232 418 4140536
SGTC_2716 st080858 38.6235 µM 1.48807716078762 0.046772919260885 no 156 0.0683652729381689 389 5296050
SGTC_110 0850-0284 111.64 µM 1.48410627016103 0.0472134690968219 no 157 0.0688903650272949 287 3906265
SGTC_3315 9136395 68.55 µM 1.48053645472898 0.0476123550526335 no 158 0.0693650697457982 439 16876844
SGTC_2166 5933061 31.504 µM 1.4797364699287 0.0477021133735566 no 159 0.0694717944064334 433 2877375
SGTC_1370 2001-0092 44.6 µM 1.47370456830782 0.0483832633040763 no 160 0.0702805761627387 514 790957
SGTC_279 1273-0055 2.93 µM 1.46751734644595 0.0490900124480606 no 161 0.0711176869982135 477 2847562
SGTC_85 0868-0259 160.055 µM 1.45992582622521 0.0499684099708177 no 162 0.0721552302212446 420 83173
SGTC_1060 3448-7350 82 µM 1.45530471626186 0.0505092160728484 no 163 0.0727924607801683 478 570178
SGTC_2115 tiliquinol 12.7705 µM 1.45347808360009 0.0507242676278799 no 164 0.0730455302220804 408 71208 A bioactive hydroxyquinoline.
SGTC_1400 3771-8998 51.5 µM 1.45311439467055 0.0507671720595716 no 165 0.0730959975122324 410 670767
SGTC_604 1000-0114 314 µM 1.45219936731737 0.0508752457791756 no 166 0.0732230892865101 485 1572745
SGTC_3327 9140648 26.9345 µM 1.4481409503556 0.0513567942258875 no 167 0.0737888174829942 428 8029710
SGTC_1703 st026983 48.3 µM 1.44471854272029 0.0517656891742524 no 168 0.074268479662429 469 1104023
SGTC_2709 st078560 56 µM 1.44193358919287 0.0521003297734798 no 169 0.0746605546890772 433 17250903
SGTC_39 0986-0283 58.349 µM 1.44130005824459 0.0521766943897916 no 170 0.0747499654285273 523 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2796 7949634 45.45 µM 1.43439596957933 0.0530146754106687 no 171 0.0757296485818818 447 2971588
SGTC_22 0964-0034 14.468 µM 1.43438054499747 0.053016559441695 no 172 0.0757318482117223 505 138402
SGTC_1717 st033143 58.0435 µM 1.43401806332063 0.0530608499472206 no 173 0.0757835540952793 514 674616
SGTC_2650 prasterone 100 µM 1.4301268050892 0.0535381608664837 no 174 0.0763403140792081 355 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2861 9024595 19.48 µM 1.42977834237686 0.0535810695509074 no 175 0.0763903234558308 324 16482810
SGTC_2493 resveratrol 26.09 µM 1.42573161037259 0.0540813700767896 no 176 0.0769729142021336 410 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1655 st012546 55.1 µM 1.42496212412723 0.0541769192963892 no 177 0.0770840749935652 423 720985 YLR208W SEC13
SGTC_2532 xanthone 78.9 µM 1.42462637785989 0.0542186516711882 no 178 0.0771326154624867 432 7020 An insecticide.
SGTC_896 0964-0007 44.5 µM 1.42319159495689 0.0543972780900743 no 179 0.0773403107379684 461 6756758
SGTC_3040 9091894 49.47 µM 1.41945312685752 0.0548648938961358 no 180 0.0778834765528724 405 25236966
SGTC_1427 4048-4900 550 nM 1.41928080424555 0.0548865247480123 no 181 0.0779085830973308 465 24132586
SGTC_1365 1672-3266 55.4 µM 1.41497195225968 0.0554295892522115 no 182 0.0785383598828021 495 6415873
SGTC_537 1334-0398 209 µM 1.41299257402964 0.0556804773626002 no 183 0.0788289537825018 492 5846986
SGTC_1811 st050069 61.5 µM 1.41223247195712 0.0557770588607928 no 184 0.0789407611157258 401 3877702
SGTC_432 NS 1619 61.3 µM 1.39762066415644 0.0576595063694179 no 185 0.0811135048320074 434 4552 A K+/calcium channel activator.
SGTC_2186 6124449 200 µM 1.39563746812081 0.0579188087612218 no 186 0.0814118467576199 455 3834182 YLR033W RSC58
SGTC_2163 5671233 125 µM 1.38627535334307 0.0591553000956933 no 187 0.0828314198894636 543 701023
SGTC_2670 beta-carotene 100 µM 1.38581932246792 0.059216054634822 no 188 0.0829010403417738 394 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_822 1487-0950 154 µM 1.38272573653476 0.0596294892078209 no 189 0.0833744886832592 469 1958375
SGTC_1751 st044839 27.194 µM 1.38245920765886 0.0596652143665196 no 190 0.0834153736767172 455 5291326
SGTC_366 0181-0206 4.31 µM 1.38025561128624 0.059961224239031 no 191 0.0837539784354254 520 274874
SGTC_1345 1488-0192 31.4 µM 1.37756829186173 0.060323767922324 no 192 0.0841683081762502 505 658348
SGTC_1432 4049-0298 68.4 µM 1.37633679101096 0.0604904807323743 no 193 0.0843586937366288 462 741646
SGTC_644 1498-1197 63.3 µM 1.37479583691107 0.0606995928649809 no 194 0.0845973745766197 535 6741615
SGTC_2080 5212524 12.4 µM 1.37325587873814 0.0609091342699894 no 195 0.084836406845763 468 260183
SGTC_2707 st078556 66.6 µM 1.37200260326199 0.061080083962348 no 196 0.0850313137035424 471 17250899
SGTC_1333 1482-0047 286 µM 1.37168074099056 0.061124047190351 no 197 0.0850814231934491 538 3811116
SGTC_2592 piperlongumine 83.33 µM 1.36909879598772 0.0614776109912857 no 198 0.0854841973192127 461 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2595 hexamethylquercetagetin 100 µM 1.36851339512071 0.0615579957400372 no 199 0.0855757160144519 479 386331
SGTC_280 3448-3607 3.04 µM 1.36806125686461 0.0616201375978683 no 200 0.085646451288938 475 626179
SGTC_1039 k821-0043 94 µM 1.36566826713051 0.0619498460187048 no 201 0.086021554355776 508 15992768
SGTC_601 0986-0029 62.9 µM 1.35970807335754 0.0627770321971485 no 202 0.0869611611486373 551 24747981
SGTC_2863 9028737 58.44 µM 1.35925909496824 0.0628396906515155 no 203 0.0870322505615813 431 6460917
SGTC_1935 st074532 41.6 µM 1.3579814695438 0.0630182599373665 no 204 0.0872347820728207 595 2829742
SGTC_3004 9076122 71.4286 µM 1.35539725436633 0.0633806547668612 no 205 0.0876455119735945 516 44782551
SGTC_2278 7948257 134.34 µM 1.35380117012339 0.0636052891259902 no 206 0.0878999101346613 495 1247028
SGTC_2121 5257820 149.641 µM 1.35089024635174 0.0640165698326136 no 207 0.0883652965490689 539 791256
SGTC_1560 lithocholic acid 53.1 µM 1.34926499042427 0.0642470980576316 no 208 0.0886259332131181 398 9903 A bile acid which acts as a detergent.
SGTC_812 4251-0442 148 µM 1.34836925500746 0.0643744257347002 no 209 0.0887698237362708 478 5723007
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.34580001370596 0.0647407281249481 no 210 0.089183510511406 548 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.34289552846979 0.0651567738753301 no 211 0.0896529022766311 499 688662
SGTC_2814 7977482 42.97 µM 1.34204125680194 0.0652795359092347 no 212 0.0897913094751174 594 6456762
SGTC_2462 5162487 171.77 µM 1.34083409988264 0.0654533147173019 no 213 0.0899871610719162 511 2259986
SGTC_1508 1080-0625 72.9 µM 1.33908196350427 0.0657061852351961 no 214 0.0902719957443436 465 767111
SGTC_3297 9117502 71.43 µM 1.33607987458654 0.066141210120749 no 215 0.0907615836541558 485 7453720
SGTC_183 3914-0051 30.55 µM 1.32844216118585 0.0672580296078177 no 216 0.0920160395202131 518 1596232
SGTC_935 2996-0153 430 µM 1.32090491405807 0.0683743964220325 no 217 0.0932665355240392 522 23738523
SGTC_2220 6782180 200 µM 1.31843561831068 0.0687432247890109 no 218 0.0936789319624726 450 833803
SGTC_945 3381-0768 11.3 µM 1.31666101273598 0.0690092362694849 no 219 0.0939761387786646 560 1126236 YIL048W NEO1
SGTC_1650 st011916 45.8 µM 1.31653216439664 0.0690285813483354 no 220 0.0939977450632945 494 242528
SGTC_374 0880-0231 82.3 µM 1.31630270068658 0.069063043003298 no 221 0.0940362323869333 553 6833587
SGTC_38 0929-0051 58.268 µM 1.31420096941067 0.0693793054552368 no 222 0.0943892911841807 580 1379719
SGTC_986 1493-0483 84 µM 1.31277765456012 0.0695941144782718 no 223 0.0946289408841298 511 40079
SGTC_1729 st035615 45.989 µM 1.31271483379664 0.0696036072777073 no 224 0.0946395286139199 535 17385451
SGTC_3024 9090631 49.47 µM 1.30821615715019 0.070285994328882 no 225 0.0954000016976444 487 25236383
SGTC_2708 st078559 56 µM 1.30686247615956 0.070492332756702 no 226 0.0956297110465212 424 17250902
SGTC_2803 7707263 71.43 µM 1.30677010839166 0.0705064291126927 no 227 0.0956453999729696 515 2199229
SGTC_2820 7989630 71.43 µM 1.30430651509373 0.0708832012044285 no 228 0.0960645474184728 433 2984098
SGTC_182 3448-4371 550.524 µM 1.30400542523367 0.070929354549672 no 229 0.0961158663043802 574 3491403
SGTC_2605 digitonin 300 nM 1.30264798784397 0.0711377195639165 no 230 0.0963474833164239 627 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_606 k015-0008 38.6 µM 1.29989494887232 0.0715617506203788 no 231 0.0968184882787434 589 1970475
SGTC_406 estrone 100 µM 1.29929795963377 0.0716539559897361 no 232 0.0969208471610931 558 5870 A steroid.
SGTC_284 0988-0104 32.6 µM 1.2976983785258 0.0719014615874162 no 233 0.0971955005390443 575 4666532
SGTC_24 0417-1663 219 µM 1.29751621893624 0.0719296889452217 no 234 0.0972268141320759 527 4329390
SGTC_3125 9127534 49.47 µM 1.29558643880047 0.072229248762926 no 235 0.0975590018599096 444 1639235
SGTC_186 3455-3465 67.277 µM 1.29260768003968 0.0726935172775719 no 236 0.0980733910129811 428 755278
SGTC_2994 9053520 71.4286 µM 1.2917480691493 0.0728279199847411 no 237 0.098222202377129 560 4647384
SGTC_1606 st000094 49.2 µM 1.28736548311022 0.0735161095643401 no 238 0.0989834646241576 581 1242210
SGTC_426 0988-0037 14.6 µM 1.28643710855224 0.073662526770565 no 239 0.0991452772908423 614 5383008
SGTC_3 0833-0587 95.581 µM 1.2815967152734 0.0744295357576573 no 240 0.099992076527146 551 5382644
SGTC_3183 9108214 49.47 µM 1.28019602853508 0.0746526222610484 no 241 0.100238101164829 408 4974831
SGTC_940 3232-1287 54.8 µM 1.27997930949082 0.0746871845057976 no 242 0.100276206375492 563 1585493 YIL048W NEO1
SGTC_80 0159-0065 512.242 µM 1.27938546934116 0.0747819524077931 no 243 0.100380674097367 412 1548079
SGTC_2685 mycophenolic acid 18.85 µM 1.27814015609931 0.0749809834596938 no 244 0.10060000613153 510 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_450 aminopyrene 156 nM 1.2760462415016 0.0753165519114821 no 245 0.100969586664989 574 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1139 k015-0024 46.9 µM 1.27559260408832 0.0753894019883106 no 246 0.101049784947711 550 2766652
SGTC_1271 0832-2808 169 µM 1.27468018692001 0.0755360905854946 no 247 0.101211231215774 589 3663794
SGTC_2199 6590217 200 µM 1.27341966674659 0.0757391010778054 no 248 0.101434581127109 480 703109
SGTC_2151 5563267 85.4165 µM 1.27242677355892 0.0758993018580362 no 249 0.101610763174926 584 5310824
SGTC_1976 st070609 63.5 µM 1.27118743718789 0.0760996275160516 no 250 0.101830987388584 593 682556
SGTC_1998 st075797 76.8 µM 1.27092011648811 0.0761428898126923 no 251 0.101878534530355 618 24208315
SGTC_875 0709-0210 25.7 µM 1.27080720232571 0.0761611690895775 no 252 0.10189862292268 618 6251364
SGTC_1184 1269-1718 139 µM 1.27044623910466 0.0762196265631694 no 253 0.101962860696237 578 5403821
SGTC_2967 9089538 49.85 µM 1.26918440161627 0.0764242476879806 no 254 0.102187651519466 599 728216
SGTC_862 0452-0056 10.2 µM 1.26833953735486 0.0765614853389091 no 255 0.102338361750651 554 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2398 5228213 48.84 µM 1.26414196096414 0.0772461098094215 no 256 0.103089539028946 670 80771 YMR134W ERG29
SGTC_704 1310-0270 142 µM 1.26286605136094 0.0774551296270587 no 257 0.103318661103453 593 5718033
SGTC_891 0929-0073 133 µM 1.26103909816601 0.0777551690178973 no 258 0.103647380449847 569 5603632
SGTC_1793 st048256 72.231 µM 1.25904578413232 0.0780835352350328 no 259 0.104006897629438 550 672022
SGTC_2648 atorvastatin 78.68 µM 1.25861411396339 0.0781547842847915 no 260 0.104084873299036 550 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1220 1838-0075 193 µM 1.25780259105398 0.0782888631729619 no 261 0.10423157920911 584 5529645
SGTC_2608 thymoquinone 42.66 µM 1.25491202352097 0.0787678568436806 no 262 0.104755349371347 528 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3160 9100216 49.47 µM 1.25387802211553 0.0789397385804039 no 263 0.104943172266168 574 17191039
SGTC_2443 5493264 126.67 µM 1.25377917338515 0.0789561850414825 no 264 0.104961140566209 584 5340055
SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.25193942139335 0.079262757030301 no 265 0.105295969378141 558 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3308 9128332 17.569 µM 1.25108417582616 0.0794055796320071 no 266 0.1054518841048 672 17332805 YDL196W YDL196W
SGTC_2879 9041815 71.43 µM 1.24863091262197 0.0798163455156811 no 267 0.105900050241595 458 4942971
SGTC_2876 9059903 25.97 µM 1.24836605397093 0.0798607884745631 no 268 0.105948517259743 624 6916095
SGTC_2415 st077333 57.7 µM 1.24768573072009 0.0799750316610622 no 269 0.106073084445835 682 2766255
SGTC_2551 apiole 73.87 µM 1.2474037940061 0.0800224120442379 no 270 0.106124738058016 417 10659 A possible DNA adduct former.
SGTC_443 clozapine 122 µM 1.24630001108456 0.0802081105608106 no 271 0.106327136904858 500 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2935 9038016 29.96 µM 1.24102213993713 0.0811005548831107 no 272 0.107298785070638 607 6463195
SGTC_603 3794-0023 45.9 µM 1.23971148117483 0.0813233335930313 no 273 0.107541064506766 566 3802260
SGTC_3287 9117173 37.0625 µM 1.23862971831207 0.0815075533025639 no 274 0.107741328582644 518 2789709
SGTC_33 0986-0033 35.816 µM 1.23519873078876 0.0820939181827131 no 275 0.108378275763587 548 2848082
SGTC_3202 9113761 49.47 µM 1.23450274145534 0.0822132513578358 no 276 0.108507812904418 655 4798415
SGTC_692 k241-0027 77.8 µM 1.23285606631999 0.0824961077153724 no 277 0.108814734570108 583 3600480
SGTC_1738 st035555 74 µM 1.23109228011386 0.0827998927059215 no 278 0.10914417626336 605 5331140
SGTC_116 0155-0182 31.788 µM 1.22963358264787 0.0830517661464067 no 279 0.109417174192833 726 771486
SGTC_1828 st055811 49 µM 1.22960037311259 0.0830575071417284 no 280 0.1094233951237 540 5877589
SGTC_210 3551-0445 56.827 µM 1.2293824356897 0.0830951898036495 no 281 0.109464226257823 601 2865180 YOR207C RET1
SGTC_3011 9081274 71.4286 µM 1.22690027291142 0.0835252778657055 no 282 0.109930037993288 638 6625322
SGTC_362 0310-0100 9.03 µM 1.22369306134722 0.0840834706531528 no 283 0.110534019082054 585 790235
SGTC_1498 4478-3555 97.6 µM 1.2224842196599 0.0842945862620074 no 284 0.110762283910373 544 3437919
SGTC_2866 9034245 58.44 µM 1.22124234704189 0.0845118844859485 no 285 0.110997137489432 548 6462273
SGTC_2032 5185112 25.99 µM 1.21313765034926 0.0859403447941862 no 286 0.112538598647484 564 5718189
SGTC_1 0258-0098 57.368 µM 1.21156573098387 0.0862194769499867 no 287 0.112839329558515 530 6790032 YDR047W HEM12
SGTC_199 4063-0024 41.6 µM 1.20851779032107 0.0867626435415281 no 288 0.113424078481865 618 306215
SGTC_705 1124-0212 310 µM 1.20772792844371 0.0869038193321296 no 289 0.113575965835023 633 9554485
SGTC_546 peri-Naphthalide 147 µM 1.20754473015643 0.0869365877424492 no 290 0.113611214858244 611 223824 A penicillin ester.
SGTC_2983 9022671 12.99 µM 1.20754375451465 0.0869367622787765 no 291 0.113611402601507 584 6405161
SGTC_2421 5690543 90.72 µM 1.20620949259956 0.0871756985872699 no 292 0.113868362350459 616 3397993
SGTC_2539 epi(13)torulosol 80 µM 1.20601981068374 0.0872097061263374 no 293 0.113904925969583 591 6708597
SGTC_1895 st058434 18.3 µM 1.2033279639425 0.0876933880866418 no 294 0.114424715912274 648 5393175
SGTC_1874 staurosporine 7.6 µM 1.2016955791103 0.0879876748430976 no 295 0.114740747303432 641 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1009 4106-0057 9.87 µM 1.19933379177403 0.0884147610955566 no 296 0.115199090284868 634 2928005
SGTC_2898 9056270 58.44 µM 1.19762444882971 0.0887248268598872 no 297 0.115531626825798 548 19154699
SGTC_1445 4239-0156 97.7 µM 1.19724589059656 0.0887936047181688 no 298 0.115605363912921 724 4008346
SGTC_1272 0839-0021 27 µM 1.19661660750848 0.0889080230309061 no 299 0.11572801216048 648 5027250
SGTC_2052 5265182 7.135 µM 1.19576895425708 0.0890623195828726 no 300 0.115893367138624 663 1239884
SGTC_2456 5770359 74.46 µM 1.19489235449241 0.0892220947430956 no 301 0.1160645452007 644 3118787
SGTC_417 st075190 100 µM 1.19426641078853 0.0893363140403793 no 302 0.116186886167971 655 222757
SGTC_758 0868-0029 16 µM 1.18612737733667 0.0908314034394095 no 303 0.117786000167654 635 762687
SGTC_2335 9018011 154.17 µM 1.1858238605927 0.0908875144801863 no 304 0.117845933280983 664 6458208
SGTC_987 1497-1013 404 µM 1.18270135152596 0.0914662656050473 no 305 0.118463764193649 598 1676435
SGTC_2886 9058944 51.95 µM 1.1811693633621 0.0917512135479821 no 306 0.118767724625747 463 4949929
SGTC_1088 bifonazole 369 nM 1.17768492295293 0.0924017631764671 no 307 0.119461119894977 646 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_84 0443-0269 128.823 µM 1.17705034252504 0.0925206066898474 no 308 0.119587706694993 663 6150058
SGTC_1424 4048-1941 275 µM 1.17393315889157 0.0931060317566035 no 309 0.120210899771515 700 X1424
SGTC_861 0443-0273 110 µM 1.17172724424749 0.0935219664038181 no 310 0.120653290595488 653 6149169
SGTC_3209 9113616 49.47 µM 1.16942455624106 0.0939576103093264 no 311 0.121116310478691 690 16649353
SGTC_1969 st069479 40.1 µM 1.16848666281181 0.0941354782613283 no 312 0.121305257978822 593 3895485
SGTC_1939 st074455 53.6 µM 1.16613545860848 0.094582466996341 no 313 0.121779841155941 650 1644229
SGTC_873 0591-4978 488 µM 1.15744054286187 0.0962490547802546 no 314 0.123546208954746 722 3305145
SGTC_588 3970-1144 52.9 µM 1.15665435797226 0.0964008033041721 no 315 0.123706802091816 672 1888707
SGTC_111 0083-0039 52.457 µM 1.15553250106603 0.0966176471892491 no 316 0.123936215584203 512 759313
SGTC_285 1486-1325 46 µM 1.15239874118881 0.0972252700260988 no 317 0.124578629019398 695 22310230
SGTC_827 3253-0474 693 µM 1.15192381620746 0.097317600117822 no 318 0.124676190282615 704 5402065
SGTC_1591 genipin 88.4 µM 1.14844081372666 0.0979966965938479 no 319 0.125393316552568 631 442424 A DNA cross-linking agent.
SGTC_568 1193-0097 7.48 µM 1.14606722014811 0.0984614721674339 no 320 0.125883669785506 676 3646150
SGTC_512 prima-1 270 µM 1.14495061835258 0.0986806723907001 no 321 0.126114806964305 691 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.14302266038452 0.0990599904319211 no 322 0.126514591392858 752 551469
SGTC_2217 6934799 96.0675 µM 1.14176435509663 0.0993081314794132 no 323 0.126775991211828 651 675606
SGTC_1815 st051655 58.2 µM 1.13981780984811 0.0996928900142285 no 324 0.127181106131984 644 5984156
SGTC_2027 5150920 200 µM 1.13525746592155 0.10059856038151 no 325 0.128133729010411 672 786715
SGTC_73 0327-0325 16.231 µM 1.13479128131334 0.10069148026529 no 326 0.128231390080482 759 53298
SGTC_1128 3448-9350 235 µM 1.13422749022238 0.100803938677181 no 327 0.128349567786425 605 619386
SGTC_1701 st028638 40.4 µM 1.13408334266274 0.100832706232518 no 328 0.12837979506278 687 3490878
SGTC_3039 9090270 49.47 µM 1.13284419055864 0.1010802509994 no 329 0.128639845101108 631 17173750
SGTC_2641 levomentholum 100 µM 1.13215860994535 0.101217399259429 no 330 0.128783878880534 634 16666
SGTC_3339 9145883 14.936 µM 1.12677884723568 0.102298313092964 no 331 0.129917998021111 649 2030670
SGTC_1191 1487-1166 10.6 µM 1.12604407163906 0.102446595032552 no 332 0.130073432646348 776 3955771
SGTC_291 SEC14.278 35.5 µM 1.12580460682304 0.102494954158727 no 333 0.130124116893674 712 1068044
SGTC_2125 5246583 200 µM 1.12315655113856 0.103030827100388 no 334 0.130685505968711 781 835267
SGTC_808 0711-0032 135 µM 1.12060512199362 0.103549068498595 no 335 0.131227991905101 692 4252555
SGTC_1977 st070720 65.3 µM 1.12022854505829 0.103625718011773 no 336 0.131308191374409 630 682188
SGTC_1398 3558-0053 112 µM 1.1195383305226 0.103766313057494 no 337 0.131455273996699 608 4532369
SGTC_3260 9137109 49.47 µM 1.11657403643151 0.104371706036963 no 338 0.132088249008887 574 17478346
SGTC_2126 5251174 33.877 µM 1.11562185529293 0.104566710509811 no 339 0.132292016470987 787 790722
SGTC_2374 9071832 200 µM 1.11556804642143 0.10457773831474 no 340 0.132303538073711 658 17381698
SGTC_513 4245-1575 41.7 µM 1.11540082042935 0.104612015654698 no 341 0.132339349064446 808 719745
SGTC_1033 k072-0102 21.3 µM 1.11040345027711 0.105640115638574 no 342 0.133412606051302 715 5965931
SGTC_817 1391-0715 46 µM 1.1085236066262 0.106028737317365 no 343 0.133817874923281 658 1353946
SGTC_973 1325-0077 65.9 µM 1.10763839848063 0.106212094470443 no 344 0.134009006587155 753 2835149
SGTC_715 0868-0130 184 µM 1.10703626692286 0.106336947508316 no 345 0.134139124289302 665 2876258
SGTC_1713 st033146 12.748 µM 1.09812687415024 0.108196725211974 no 346 0.136074545936436 723 674619
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.09781789688536 0.108261639634154 no 347 0.13614200746483 702 756377
SGTC_3345 9148410 3.559 µM 1.09723265325026 0.108384672920009 no 348 0.136269851217471 691 4903596
SGTC_2248 tofa 1.1 µM 1.09381478319403 0.109105207015461 no 349 0.137018109563772 679 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1693 xanthone 101.9 µM 1.09364321190569 0.109141467128873 no 350 0.137055744725385 741 7020 An insecticide.
SGTC_592 k241-0073 46.5 µM 1.09280201400913 0.109319372369073 no 351 0.137240368587039 745 4230158
SGTC_283 0987-0079 11.7 µM 1.09015722102141 0.109880077495377 no 352 0.137821946948626 749 411556
SGTC_2375 9072683 200 µM 1.08986843963987 0.109941424887969 no 353 0.137885550379845 796 16798029
SGTC_607 4491-0986 66.8 µM 1.08725796084651 0.110497098547176 no 354 0.138461410928342 737 698981 YDR232W HEM1
SGTC_487 nimodipine 119 µM 1.08480408081643 0.111021271336341 no 355 0.139004218870288 609 4497 L-type voltage-gated calcium channels inhibitor
SGTC_670 4204-0025 119 µM 1.08414981237827 0.111161329713397 no 356 0.139149189920565 756 719039
SGTC_189 3970-0742 2.116 µM 1.08070508381253 0.111900824925373 no 357 0.139914160481788 712 2891807
SGTC_2441 5730946 39.09 µM 1.07779810305807 0.112527611054143 no 358 0.140561933143416 733 1774275
SGTC_156 3474-0145 5.642 µM 1.07758614908975 0.112573409219612 no 359 0.140609243083742 742 2265471
SGTC_2919 7978188 46.38 µM 1.07730288498503 0.112634636577468 no 360 0.140672486929231 745 2980291
SGTC_2890 9046729 58.44 µM 1.07299395937065 0.113568941874748 no 361 0.141636913210349 663 903329
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.07288350685993 0.113592963738229 no 362 0.141661693495061 733 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_3144 9087057 49.47 µM 1.06875271380175 0.11449395544988 no 363 0.142590555837525 713 17249618
SGTC_910 3454-3003 490 µM 1.06720201690289 0.114833496921717 no 364 0.142940311000545 742 820824
SGTC_2669 eugenol 100 µM 1.06602209594545 0.115092332536238 no 365 0.14320682681025 683 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2717 st081029 62.2815 µM 1.06561332340108 0.115182100387649 no 366 0.14329923694423 721 5292846
SGTC_158 k038-0087 26.446 µM 1.06508335947297 0.11529855636856 no 367 0.143419104432488 829 X158
SGTC_193 1273-0060 1.558 µM 1.0634306186716 0.115662272362979 no 368 0.143793356778949 639 2847393 YHR072W ERG7
SGTC_564 3555-0129 330 µM 1.06264536376797 0.115835367453091 no 369 0.143971403317352 655 563260
SGTC_2791 5663188 71.43 µM 1.05915913481324 0.116606063975445 no 370 0.144763656203353 710 54690634
SGTC_2439 5492030 7.2 µM 1.05725940363256 0.117027562672211 no 371 0.145196607709794 728 5722370
SGTC_1700 st030840 7.9285 µM 1.05609783646827 0.117285814114091 no 372 0.14546175937832 783 5499307
SGTC_2488 5268135 45.7 µM 1.05536917693261 0.117448023006076 no 373 0.145628257069808 817 1270356 YLR208W SEC13
SGTC_1875 nocodazole 6 µM 1.05407147465025 0.117737301297592 no 374 0.145925097432926 752 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1031 k035-0009 16 µM 1.05040966977676 0.11855629310821 no 375 0.146764900865377 815 5180959
SGTC_2840 9008771 71.43 µM 1.04979679881073 0.11869375892077 no 376 0.146905773683608 694 2992978
SGTC_3316 9136639 10.545 µM 1.04973204400921 0.118708289876736 no 377 0.1469206633382 745 4903665
SGTC_1434 4073-0095 163 µM 1.04916758011475 0.118835008615056 no 378 0.147050498470883 795 24133745
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.04740008671594 0.119232418105968 no 379 0.14745754587267 583 6708630 An antioxidant.
SGTC_3133 9127736 49.47 µM 1.04644682729101 0.119447141304017 no 380 0.147677391189528 756 27243420
SGTC_2918 7977171 22.06 µM 1.0454262340027 0.119677333820706 no 381 0.147913008577077 747 2236483
SGTC_2 0422-0095 29 µM 1.04201159900271 0.120449770892405 no 382 0.148703150680277 633 6790840
SGTC_2555 cholic acid 100 µM 1.04080364988837 0.120723864421165 no 383 0.148983342882874 759 6708657 Influences liver metabolism.
SGTC_1877 wortmannin 25 µM 1.04043596812651 0.120807381512299 no 384 0.14906869919995 805 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1418 3966-3099 2.4 µM 1.04025655051866 0.120848150093165 no 385 0.149110362364347 777 740335
SGTC_2871 9038510 12.99 µM 1.0331634849508 0.122467651862874 no 386 0.150763698950163 798 4945164
SGTC_1260 0700-1617 7.75 µM 1.03239517743522 0.122643983126601 no 387 0.150943515103552 784 2853078
SGTC_3230 9131665 49.47 µM 1.03226570312988 0.122673715796699 no 388 0.150973831564936 646 15943720
SGTC_1066 ketoconazole 628 nM 1.032196789402 0.122689543308296 no 389 0.150989969394782 810 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_685 1278-0033 54.9 µM 1.03152714050937 0.122843417088475 no 390 0.151146843788451 783 3590572
SGTC_219 mitoxanthrone 164.414 µM 1.0301400630281 0.123162573949491 no 391 0.151472130439164 735 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_3168 9103419 49.47 µM 1.02159353483555 0.12514189239204 no 392 0.153486659442499 702 16649256
SGTC_2218 6965428 192.983 µM 1.01859087886359 0.125842532014211 no 393 0.154198618158633 778 675684
SGTC_2642 cholecalciferol 100 µM 1.01550349852862 0.126565789235261 no 394 0.15493293985477 785 9821465 A vitamin D precursor, similar to steriods.
SGTC_2311 7694451 200 µM 1.01471228894337 0.126751605078004 no 395 0.155121497231178 772 2163142
SGTC_2124 5246320 200 µM 1.01234173625719 0.127309467009031 no 396 0.155687342904132 771 579342
SGTC_1556 plumbagin 1.48 µM 1.01159938241503 0.127484515703067 no 397 0.155864820657263 729 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3329 9141233 27.5565 µM 1.00981660959389 0.127905580907016 no 398 0.156291580462936 772 4909101 YNL103W MET4
SGTC_3084 9116877 49.47 µM 1.00883253148922 0.128138419428063 no 399 0.156527478270338 742 27241325
SGTC_1825 st052143 62.6 µM 1.00677178244386 0.128626957761465 no 400 0.157022228815175 763 674173
SGTC_408 cantharidin 100 µM 1.00607638056787 0.128792106817516 no 401 0.157189414765577 799 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2475 5812728 15.03 µM 1.0054968614302 0.128929847531006 no 402 0.157328830001691 837 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_3164 9100705 49.47 µM 1.00431327906014 0.129211479950635 no 403 0.15761381752245 756 17174235
SGTC_3246 9135460 32.98 µM 1.0027996661731 0.12957226384886 no 404 0.157978764976982 724 41446951
SGTC_2162 5663267 200 µM 1.0023429319152 0.129681267693026 no 405 0.158088997126404 843 6456493
SGTC_155 k072-0202 43.6 µM 0.999737522492217 0.130304287112641 no 406 0.158718774139404 787 5857737
SGTC_2691 st077356 60.2 µM 0.997493274042911 0.130842601306738 no 407 0.159262568459367 830 2839272
SGTC_2309 7664088 163.95 µM 0.992317112439286 0.13209003017573 no 408 0.160521429104655 866 704922
SGTC_2899 9053889 58.44 µM 0.990770558837701 0.13246432778773 no 409 0.160898814195627 797 6470052
SGTC_2024 5144227 134 µM 0.990205617485997 0.132601237226546 no 410 0.161036813695855 850 3475211
SGTC_1698 5-fluorocytosine 1.055 µM 0.990096644741011 0.132627657192156 no 411 0.161063441598578 815 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1813 st051246 8.6015 µM 0.987047114355425 0.133368473386664 no 412 0.16180977107737 805 5291959
SGTC_2160 5660466 132.927 µM 0.986338046856291 0.133541132818262 no 413 0.161983627720091 785 2859134
SGTC_3003 9075612 71.4286 µM 0.986062664009612 0.133608230547888 no 414 0.162051181782064 788 6501993
SGTC_1756 st041558 35.5 µM 0.985964309839828 0.133632200408404 no 415 0.162075313452648 900 3955792
SGTC_475 α-linolenic acid 10 µM 0.982610616714603 0.134451297500774 no 416 0.162899558596251 868 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_478 N-arachidonylglycine 10 µM 0.981335539359673 0.134763621533082 no 417 0.163213651253031 719 5283389
SGTC_884 0851-0618 334 µM 0.981055790474696 0.1348322112079 no 418 0.16328261502768 845 9642473
SGTC_735 3076-0345 636 µM 0.980338807438016 0.13500811261062 no 419 0.163459452318955 862 2888990
SGTC_1908 st060353 56.5 µM 0.979917594374813 0.135111524494497 no 420 0.163563398639307 885 4227716
SGTC_2223 6903751 107.57 µM 0.979240863919888 0.135277782080014 no 421 0.163730491010467 767 5598863
SGTC_2845 9003024 42.97 µM 0.978463032539029 0.135469051080379 no 422 0.163922683162621 826 2990173
SGTC_2934 9036370 36.88 µM 0.972411107786503 0.136963551247068 no 423 0.165423034065769 855 6462800
SGTC_2341 7987486 176.74 µM 0.971917911123792 0.137085838916585 no 424 0.165545694219582 861 1258686
SGTC_2187 6125751 200 µM 0.971640369440353 0.137154687918713 no 425 0.165614745902387 840 874498
SGTC_2350 9023895 38.85 µM 0.971389376259547 0.137216971443724 no 426 0.165677208420285 814 2997209
SGTC_3152 9099253 49.47 µM 0.968462709673517 0.137944644745403 no 427 0.166406666973961 901 25236131
SGTC_1627 st003713 25.6 µM 0.968308052219436 0.137983171172867 no 428 0.166445272253448 898 16195070 YER133W GLC7
SGTC_2586 curcumin 80 µM 0.967518050394892 0.138180081528729 no 429 0.166642561100332 916 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2963 9082507 9 µM 0.966087459333762 0.138537148120574 no 430 0.167000209594838 764 16459611
SGTC_225 nsc-122657 1.016 µM 0.965524709611384 0.138677779080604 no 431 0.167141032872725 708 275685
SGTC_1808 st050063 61.5 µM 0.961429712910227 0.139704045466814 no 432 0.168168075215945 841 4011993
SGTC_2622 2-methoxyxanthone 59.94 µM 0.961382135220755 0.139715999401704 no 433 0.168180031712007 900 71034 A hepatoprotective.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.959639458949681 0.140154327553514 no 434 0.168618351283111 831 616764
SGTC_2784 7567673 72.73 µM 0.95809833513949 0.140542737614209 no 435 0.169006587458583 875 3471247
SGTC_2085 5307070 144.047 µM 0.957442154246411 0.140708336733727 no 436 0.169172065093143 791 2840351
SGTC_1923 st058458 19.1 µM 0.957339000431815 0.140734381504179 no 437 0.169198088185928 907 3534982
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.956829279958819 0.140863126195728 no 438 0.169326715466382 851 4213774
SGTC_1248 0469-0687 58.6 µM 0.95501585473162 0.141321806994834 no 439 0.169784839610433 858 4017482
SGTC_500 h-89 112 µM 0.953783781711987 0.141634019763951 no 440 0.170096550264333 904 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2167 5876490 200 µM 0.952008076094945 0.142084812893579 no 441 0.170546443042076 867 686534
SGTC_1490 4089-0339 670 nM 0.95193233342572 0.142104063032642 no 442 0.170565650132335 830 742542
SGTC_2490 carminic acid 95.39 µM 0.951380249296001 0.142244429557633 no 443 0.17070569138775 795 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_67 0335-0847 266 µM 0.947944175311198 0.143120154675012 no 444 0.171578937188483 957 4552207 YOR254C SEC63
SGTC_1971 st069429 63.5 µM 0.946155711693833 0.143577404549673 no 445 0.172034585776116 868 1246522 YGL099W LSG1
SGTC_2207 7258803 200 µM 0.944419231493273 0.144022306491583 no 446 0.172477728866779 813 3666799
SGTC_2237 6667747 47.222 µM 0.943547232757361 0.144246070758802 no 447 0.172700533937383 819 729940 YDL015C TSC13
SGTC_1117 retinoic acid 1.10837 µM 0.942473007184676 0.144522050641413 no 448 0.172975262262786 920 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_563 tetrahydrosecaminediol 614 µM 0.942354294863773 0.144552570904453 no 449 0.173005639477664 906 334274 A psychoactive constituent of the cannabis plant.
SGTC_1979 st071809 45.3 µM 0.941766913940902 0.144703647096319 no 450 0.173155993989068 883 4976333
SGTC_2004 4023728 41.89 µM 0.94108484658027 0.144879210331999 no 451 0.173330690202602 879 360084 YDR527W RBA50
SGTC_1624 st003710 6.25 µM 0.937823539375152 0.145720648261107 no 452 0.174167550963389 914 24207033
SGTC_2257 7960413 200 µM 0.936680212524976 0.146016410021215 no 453 0.17446153883156 912 2974689 YIL048W NEO1
SGTC_876 0720-0963 56.8 µM 0.93631648747251 0.146110584819954 no 454 0.174555130851069 904 765861
SGTC_1332 1480-0653 17.5 µM 0.935578266066186 0.146301848712989 no 455 0.174745184521099 870 5749438
SGTC_3157 9099274 49.47 µM 0.932454788137708 0.147112962531344 no 456 0.17555077084027 859 17217662
SGTC_1022 4477-0945 21.3 µM 0.932380496567407 0.147132291419795 no 457 0.175569960232288 872 4648966
SGTC_2932 9016711 44.54 µM 0.93217801808463 0.14718498011835 no 458 0.175622266844037 927 7117328
SGTC_1035 k081-0041 55.2 µM 0.92720846814689 0.148482115305883 no 459 0.176909153484468 924 731709
SGTC_3205 9113483 49.47 µM 0.927034491456939 0.148527664187629 no 460 0.176954313210466 881 17018033
SGTC_1266 0828-0227 32.9 µM 0.925428478201155 0.148948576108801 no 461 0.177371535529193 852 3913820
SGTC_442 cape 100 µM 0.923919248602828 0.149344848159565 no 462 0.1777641802466 866 5281787
SGTC_1122 capsaicin 818.572 nM 0.921262366117606 0.150044163302912 no 463 0.178456732187751 895 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1198 1612-1005 86.7 µM 0.918959339777926 0.1506521040233 no 464 0.179058420031539 910 6998509
SGTC_3219 9131112 49.47 µM 0.918185120072461 0.150856846354218 no 465 0.179260978723744 856 17612988 YMR079W SEC14
SGTC_2225 6654152 15.4 µM 0.917959734828272 0.150916484255208 no 466 0.179319973217295 837 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1740 st038286 13.222 µM 0.91572381053778 0.151508969367081 no 467 0.179905886613069 863 716786
SGTC_938 3126-1755 342 µM 0.910856289083899 0.15280412779084 no 468 0.181185549676144 947 1777771
SGTC_632 0781-2353 4.65 µM 0.907694486057463 0.153649348152081 no 469 0.182019828986897 924 6811515 YHR007C ERG11
SGTC_3226 9131256 49.47 µM 0.906907597587204 0.153860181110257 no 470 0.182227831548561 821 17178073
SGTC_2316 5844804 197.44 µM 0.90459266423423 0.154481536579777 no 471 0.182840611531981 1040 776813
SGTC_871 0574-0004 149 µM 0.904370849673316 0.154541161192788 no 472 0.182899394935601 904 9551173
SGTC_1312 1218-2183 165 µM 0.903292031452062 0.15483136857555 no 473 0.183185462294256 937 6744073
SGTC_2130 NSC 7 2.4545 µM 0.90220428256755 0.155124342603899 no 474 0.183474180150791 942 21448
SGTC_1642 st009582 77.7 µM 0.897370423557935 0.156430717599266 no 475 0.184760644648755 887 6739311
SGTC_2226 7298446 200 µM 0.896635750437624 0.156629899155052 no 476 0.184956657428401 893 3283010
SGTC_1450 4112-4260 37.6 µM 0.895557982871402 0.156922401041914 no 477 0.185244442456877 953 1633175
SGTC_1456 k015-0012 13 µM 0.893617576628521 0.157449925055231 no 478 0.185763269419025 993 2989616
SGTC_27 0485-0001 32.618 µM 0.892657951695715 0.157711241480703 no 479 0.186020187283228 861 2054479
SGTC_2847 9005661 71.43 µM 0.891308724620701 0.158079132456366 no 480 0.186381784699766 825 2991449
SGTC_435 c-PAF 6.7 µM 0.890784816466537 0.158222137133606 no 481 0.186522311143323 931 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_3305 9127027 53.8275 µM 0.889846463560776 0.158478479757965 no 482 0.186774166917799 925 41905295
SGTC_2262 9014885 67.46 µM 0.888873007186034 0.158744699796504 no 483 0.187035666869839 880 6457424
SGTC_1216 1165-0504 9.65 µM 0.888840655426099 0.158753552359531 no 484 0.187044361422129 944 6304004
SGTC_623 k072-0108 16.9 µM 0.887927811703495 0.159003471438948 no 485 0.187289791694285 912 5382803
SGTC_1563 conessine 56.1 µM 0.886115060083045 0.159500531872017 no 486 0.187777764230444 1045 441082 An anti-amoebic, histamine inhibitor.
SGTC_3251 9135047 49.47 µM 0.885956464273737 0.159544067522754 no 487 0.187820493778227 914 17682963
SGTC_1572 epiandrosterone 68.9 µM 0.88294973711088 0.160370906348884 no 488 0.188631714507204 959 441302 A steroid.
SGTC_1634 st006576 41 µM 0.882866739092634 0.160393770140923 no 489 0.188654138123878 930 3915356
SGTC_1524 corynanthine 62.1 µM 0.88266082949785 0.160450502067176 no 490 0.188709775918469 895 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2545 solidagenone 89.61 µM 0.881065832916717 0.160890397369506 no 491 0.189141094440544 718 6708572 An anti ulcer agent
SGTC_882 0843-0131 351 µM 0.878813135551043 0.16151302450104 no 492 0.189751301461055 977 5425421
SGTC_63 0099-0242 26.702 µM 0.878436202972969 0.1616173588042 no 493 0.18985352246188 988 3898502 YLR359W ADE13
SGTC_1579 chlormadinone acetate 49.4 µM 0.877092625942248 0.161989615990028 no 494 0.190218164818431 961 45114258 A steroidal progestin.
SGTC_1010 4112-3296 15.2 µM 0.876442172454548 0.162170033894137 no 495 0.190394850213058 975 704384
SGTC_2221 6807166 181.081 µM 0.875598181677135 0.16240432867512 no 496 0.190624257128926 896 674925
SGTC_988 1497-1057 103 µM 0.875063670783774 0.162552824648958 no 497 0.190769631380057 961 3533044
SGTC_2910 7948405 25.97 µM 0.871768496828975 0.163470228932989 no 498 0.191667342003614 917 2971328
SGTC_1058 3448-5425 97.3 µM 0.871693244234447 0.163491219089908 no 499 0.191687873384554 921 7279705
SGTC_609 0986-0026 86.3 µM 0.870994966797805 0.163686072630418 no 500 0.191878450646008 936 2848610
SGTC_933 2914-0560 114 µM 0.866181446758552 0.165033379746209 no 501 0.193195333048239 1010 463887
SGTC_3207 9114163 49.47 µM 0.864420580975705 0.165528035760128 no 502 0.193678445478381 990 849233
SGTC_1814 st052110 31.539 µM 0.864226527983062 0.165582607025954 no 503 0.193731731025995 958 674163
SGTC_2915 7971052 15.16 µM 0.863719096711501 0.165725361006237 no 504 0.193871110219556 806 5741558
SGTC_1041 0206-0046 107 µM 0.862471202608073 0.166076765331965 no 505 0.194214136657884 948 50494
SGTC_227 fluconazole 33.516 µM 0.861285247820925 0.166411173513026 no 506 0.1945404792974 995 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1552 6-methylflavone 10.6 µM 0.860525903314744 0.166625516912869 no 507 0.194749605482201 936 689013
SGTC_851 0394-0702 453 µM 0.859319714374965 0.166966359125113 no 508 0.195082075227348 1012 762646
SGTC_205 1486-1330 71.903 µM 0.859097821581364 0.167029110036577 no 509 0.195143274540491 934 4118834
SGTC_651 3253-0966 34.4 µM 0.857034756279159 0.167613269362214 no 510 0.195712838285694 976 781462
SGTC_2518 prenyletin 46.28 µM 0.854951569878178 0.168204459565867 no 511 0.196288979730756 890 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_223 busulfan 5 mM 0.854443813884976 0.168348759394514 no 512 0.196429564183521 891 2478 A DNA alkylator.
SGTC_1239 0337-0584 35.4 µM 0.854255737676355 0.168402229215226 no 513 0.196481653087072 1018 914301 YML130C ERO1
SGTC_3265 9137266 49.47 µM 0.850606831165272 0.169441769459089 no 514 0.197493896738854 954 17224265
SGTC_4 0960-0234 25.671 µM 0.849701190662985 0.169700414715152 no 515 0.197745618150562 947 6821112
SGTC_2888 9058547 12.99 µM 0.848477830387619 0.170050200593909 no 516 0.198085956962303 881 16476514
SGTC_2644 guaiazulene 100 µM 0.848071270567886 0.170166547308393 no 517 0.198199140155477 1005 3515 A coloring agent.
SGTC_1972 st070201 17.4 µM 0.847611416458015 0.170298206906852 no 518 0.198327207118937 978 2829099
SGTC_2076 5212012 200 µM 0.847349399491209 0.170373253459032 no 519 0.198400199802102 882 604802
SGTC_1673 st016611 27.3 µM 0.845215987958431 0.170985090590257 no 520 0.198995128670877 997 5226799
SGTC_1491 4138-0063 26.5 µM 0.844965919228086 0.17105689925963 no 521 0.199064933829135 975 23883227
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.844731453666813 0.17112424490866 no 522 0.199130396857544 812 4000243
SGTC_2523 spermine 47.74 µM 0.843638182233472 0.171438489587751 no 523 0.199435810555509 974 1103 A DNA binding polyamine.
SGTC_1974 st069448 26.9 µM 0.840776097007158 0.172262898918076 no 524 0.200236690194884 987 6323587 YNR016C ACC1
SGTC_65 0798-0905 34.986 µM 0.83986020136454 0.172527251444333 no 525 0.200493387243783 1035 3602145
SGTC_3001 9076041 71.4286 µM 0.838830188707202 0.172824850147269 no 526 0.200782303722494 967 16004211
SGTC_147 4466-0538 29.23 µM 0.836119544110018 0.173609591479223 no 527 0.201543827231451 1106 6742687 YHR072W ERG7
SGTC_263 alizarin 107.927 µM 0.835160623498382 0.173887744496529 no 528 0.201813638462283 1037 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2413 inermin 26.06 µM 0.833475824235948 0.174377138284131 no 529 0.202288213471034 1010 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1736 st036774 51 µM 0.831834652125904 0.174854699904718 no 530 0.20275114077289 1046 1272247
SGTC_699 0375-0592 111 µM 0.829680213687058 0.175482874717219 no 531 0.20335980565104 1046 762578
SGTC_1521 st012942 49.4 µM 0.827857009635519 0.176015586730971 no 532 0.203875742007525 1032 24207259
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.826079168745041 0.176536029238639 no 533 0.204379591823275 949 279621
SGTC_1999 st074831 12.5 µM 0.826055324432081 0.176543015995203 no 534 0.204386354465379 992 17112523
SGTC_2704 st078022 71.1 µM 0.825571312491543 0.176684876865855 no 535 0.204523657061662 1014 54697681
SGTC_1100 amiodarone 5.07 µM 0.825247675183314 0.176779773132499 no 536 0.204615495829756 1049 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2292 7671323 168.05 µM 0.824211174365372 0.177083910553383 no 537 0.204909789415914 985 937504
SGTC_2764 methyldopa 94.69 µM 0.824203634163839 0.177086124263206 no 538 0.204911931226317 1001 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2495 cafestol 54.53 µM 0.8230993495138 0.177410517320009 no 539 0.205225749348456 952 16667697 An anti-infammatory.
SGTC_2740 felodipine 17.08 µM 0.822020424319415 0.177727822905403 no 540 0.205532636379107 959 3333 L-type calcium channel blocker
SGTC_2275 7947463 200 µM 0.820329193007009 0.178225924135817 no 541 0.206014234274831 996 1225414
SGTC_1157 4092-0394 27.6 µM 0.818846728884986 0.178663262153688 no 542 0.206436933195206 1078 3659885
SGTC_1620 st003704 16.5 µM 0.817813625601468 0.178968434549361 no 543 0.206731808260978 1015 2834414
SGTC_2566 crystal violet carbinol 226 nM 0.816037991843954 0.179493711764969 no 544 0.207239203477296 923 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_757 1066-0008 322 µM 0.816003120339204 0.179504037328273 no 545 0.207249175532541 1030 6842497
SGTC_3105 9121040 49.47 µM 0.81499855798144 0.179801651719641 no 546 0.207536567752864 824 41448907
SGTC_2141 5621638 7.665 µM 0.814589429938597 0.179922949888661 no 547 0.207653681423656 1026 2856238
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.810552386484814 0.181122605478688 no 548 0.20881138469199 1041 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1835 st008666 49.2 µM 0.810231461594555 0.181218186656936 no 549 0.208903579243915 918 690455
SGTC_1158 4092-0494 91.8 µM 0.809987529984169 0.181290858025877 no 550 0.208973671384394 1068 1148199
SGTC_2955 9076254 12.21 µM 0.809078074806233 0.181561960992277 no 551 0.209235119405188 985 16459619
SGTC_2568 diosmetin 100 µM 0.806794025005169 0.182243940176772 no 552 0.209892581055484 1042 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1913 st060213 96.1 µM 0.804780693574987 0.182846413070565 no 553 0.210473122289407 1065 688959
SGTC_3214 9129694 49.47 µM 0.804467972213596 0.182940103787222 no 554 0.210563379535371 997 17158655
SGTC_249 wiskostatin 11.211 µM 0.80388620741945 0.183114479087262 no 555 0.210731348175856 1053 2775510 A n-wasp and actin depolymerizer.
SGTC_3150 9097574 49.47 µM 0.802050431104268 0.18366540508702 no 556 0.211261893338743 1027 17217476
SGTC_1699 st031318 29.054 µM 0.801849914699336 0.183725643602749 no 557 0.211319890582605 1068 5340658
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.801108137710235 0.183948592914092 no 558 0.211534522765983 1033 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_297 0986-0032 24 µM 0.798240198891779 0.184812167647329 no 559 0.212365556862343 1021 2847425
SGTC_2804 7954240 19.48 µM 0.798236585663255 0.184813257225711 no 560 0.212366605058669 1039 828705
SGTC_2767 sibutramine 71.45 µM 0.797681811867448 0.184980598062558 no 561 0.212527580606437 1046 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_939 1165-0479 45.3 µM 0.797281260712652 0.185101478003003 no 562 0.212643850545628 1033 1377347
SGTC_994 3910-0338 138 µM 0.796105715473754 0.185456522010436 no 563 0.212985296204263 1069 3479481
SGTC_45 0kpi-0036 14.9 µM 0.795985097775721 0.185492975462428 no 564 0.213020348578342 1006 2795021
SGTC_3178 9107506 49.47 µM 0.794734676469559 0.185871143620589 no 565 0.213383928298745 1022 8897194
SGTC_2298 7976326 193.81 µM 0.794164781057446 0.186043657070265 no 566 0.213549754313116 961 2235818
SGTC_3232 9132874 49.47 µM 0.793859175721453 0.186136207953706 no 567 0.213638709121721 1038 3784940
SGTC_3142 9086498 49.47 µM 0.79362516615525 0.186207095742961 no 568 0.213706838610743 1007 25236367
SGTC_2064 5220758 200 µM 0.793059240594198 0.18637859895371 no 569 0.213871654345037 1081 788518
SGTC_1315 1237-0019 3.69 µM 0.792917988557249 0.186421420506358 no 570 0.213912803022445 1069 825140
SGTC_1555 citronellol 128 µM 0.792695710993162 0.186488817859314 no 571 0.213977564892501 1028 8842 A terpine precursor.
SGTC_2431 5490079 200 µM 0.792660801915876 0.186499404101576 no 572 0.213987736893514 1102 5722345
SGTC_796 1234-0020 70.7 µM 0.792467437423756 0.186558048981526 no 573 0.214044085611671 1062 46495034
SGTC_1997 st073024 93.8 µM 0.792291637858148 0.186611376562256 no 574 0.214095323195135 1056 686268
SGTC_3108 9121785 49.47 µM 0.792269875833488 0.186617978578173 no 575 0.214101666332703 1042 17140271
SGTC_2048 5246248 200 µM 0.791281892543528 0.186917858574761 no 576 0.214389756269185 1044 677046
SGTC_3013 9080133 71.4286 µM 0.79031521522391 0.187211560049374 no 577 0.214671851587867 1106 17050193
SGTC_3139 9095020 49.47 µM 0.790138717073687 0.18726521552739 no 578 0.214723380473334 879 25236292
SGTC_1403 3909-7815 62.9 µM 0.790121516692853 0.187270444955507 no 579 0.214728402533249 1027 6615483
SGTC_535 2293-4129 48.2 µM 0.789199019541193 0.187551043837493 no 580 0.214997847475134 1109 396118 YIL048W NEO1
SGTC_2914 7968218 45.32 µM 0.789139404399281 0.187569186096891 no 581 0.215015266744789 984 2977111
SGTC_2783 7738165 71.43 µM 0.787776272324585 0.18798431438159 no 582 0.215413791207397 979 17201110
SGTC_3262 9137218 49.47 µM 0.786825735011035 0.188274126436096 no 583 0.215691943126275 930 17650664
SGTC_1638 st008370 60.6 µM 0.785807892557381 0.188584764796152 no 584 0.215990021010547 1072 24207134
SGTC_16 erodoxin 22.806 µM 0.785697744930565 0.188618400015799 no 585 0.216022292341469 1105 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3043 9092303 49.47 µM 0.784574469519415 0.188961620045213 no 586 0.216351551864553 1036 25236084
SGTC_1453 4237-0541 195 µM 0.783232884305127 0.18937204908313 no 587 0.21674518373755 1077 739892
SGTC_3176 9106582 49.47 µM 0.782304634180445 0.189656348082752 no 588 0.217017782019025 969 17018027
SGTC_3095 9117207 49.47 µM 0.780435957928205 0.190229471005805 no 589 0.217567154791088 1029 17015229
SGTC_1941 st076221 61.8 µM 0.77995294880999 0.190377782760841 no 590 0.217709285241708 1093 2828568
SGTC_1520 flindersine 88 µM 0.777095232693706 0.191256719269739 no 591 0.218551293209283 1111 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3065 9113888 49.47 µM 0.776036610161321 0.191582946034781 no 592 0.218863684949352 1037 16648368
SGTC_1024 4507-0395 26 µM 0.775857067822873 0.19163830786829 no 593 0.218916692044043 1050 4201836
SGTC_334 1502-1024 68.5 µM 0.775632044178102 0.191707707685251 no 594 0.218983137217109 1118 3296216
SGTC_742 0kpi-0133 140 µM 0.775028892945342 0.191893802194072 no 595 0.219161293428745 1094 2728852
SGTC_517 1365-0151 113 µM 0.774951466172928 0.191917699229096 no 596 0.219184169448625 1047 768657
SGTC_1305 1181-0477 144 µM 0.774403600757337 0.192086844708172 no 597 0.219346077483189 1064 6252086
SGTC_2336 9001819 198.65 µM 0.774345264164188 0.192104860654793 no 598 0.21936332146414 1099 2989602
SGTC_1861 st057647 17.4 µM 0.773224288065088 0.192451249725617 no 599 0.219694827198503 1084 688668
SGTC_1837 st055472 66.5 µM 0.773106411124846 0.192487696660095 no 600 0.219729703596966 1088 676091
SGTC_852 0418-0143 439 µM 0.770397647415385 0.193326394483577 no 601 0.220532024262132 1148 5369229
SGTC_2014 4013930 200 µM 0.768076270018707 0.194046919736585 no 602 0.221220937004935 1094 64556
SGTC_1245 0418-0076 17.2 µM 0.767993102909918 0.194072764043271 no 603 0.221245641241987 1057 6790114
SGTC_1809 st050081 57.6 µM 0.767682174893395 0.194169403975079 no 604 0.221338014319986 1108 5036894
SGTC_1750 st081859 2.357 µM 0.766636400967954 0.194494657320639 no 605 0.221648863315818 1149 5291695
SGTC_1796 st049173 110.4 µM 0.766514830558243 0.194532489274349 no 606 0.221685015449791 1049 94134
SGTC_1882 5615643 20 µM 0.764213815614548 0.195249395125366 no 607 0.222369917397741 1053 2253075
SGTC_846 0335-0850 148 µM 0.763064552222457 0.195608060811798 no 608 0.22271244955043 1085 6819598
SGTC_1590 st077108 57.8 µM 0.760328702007086 0.196463481593502 no 609 0.223529064749541 1076 5489485
SGTC_2978 9011784 42.97 µM 0.759679936126492 0.196666663858558 no 610 0.223722962331153 1176 2994934
SGTC_1089 terbinafine 2.25 µM 0.758893384834851 0.196913168765497 no 611 0.223958168225078 1083 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1649 st011737 51.3 µM 0.757357013807543 0.197395206134906 no 612 0.224418001029527 1062 1761035
SGTC_2324 6149169 200 µM 0.75645048405336 0.197679964873578 no 613 0.224689574758038 1059 2888231
SGTC_3289 9119912 71.43 µM 0.756103863460974 0.197788910765353 no 614 0.224793462890513 1110 17014829
SGTC_2305 7443522 69.23 µM 0.752936341803446 0.198786170222909 no 615 0.225744084164718 1097 5415886
SGTC_3096 9117468 49.47 µM 0.751772493602161 0.199153355287605 no 616 0.226093943112146 1023 41316311
SGTC_649 1123-0311 367 µM 0.75171869324503 0.199170338756079 no 617 0.226110123192104 1101 693629 YIL048W NEO1
SGTC_2997 9067075 71.4286 µM 0.751187139799684 0.199338184178745 no 618 0.226270019330144 1113 27209819
SGTC_855 0428-0020 25 µM 0.750755578060862 0.199474518448505 no 619 0.226399884018849 1056 6812414
SGTC_663 1486-0733 13.9 µM 0.750403419365274 0.199585810153043 no 620 0.226505886085045 1093 722445 YPR165W RHO1
SGTC_2544 sphondin 68.51 µM 0.750002873254286 0.199712439005014 no 621 0.226626487133383 1123 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_3052 9092717 49.47 µM 0.748920328624677 0.200054916982381 no 622 0.226952613452104 1111 25237534
SGTC_2891 9063876 19.48 µM 0.747678449721359 0.200448237094035 no 623 0.227327066419366 1080 6472478
SGTC_989 1501-0895 10.3 µM 0.747613379774267 0.200468858437949 no 624 0.22734669598853 1122 2830112
SGTC_2928 9011484 9.79 µM 0.747604170267614 0.200471777129446 no 625 0.227349474285971 1089 2994751
SGTC_3195 9113082 49.47 µM 0.74647301805684 0.200830457735475 no 626 0.227690862456684 1090 17018038
SGTC_1314 1222-0010 41.1 µM 0.74547750447051 0.201146446661276 no 627 0.227991552709481 1109 3526027
SGTC_762 1165-0429 115 µM 0.744590224260146 0.201428332046817 no 628 0.228259739726827 1125 5967793
SGTC_2373 9071805 200 µM 0.744563045883819 0.201436970243908 no 629 0.228267957390576 1128 10149009
SGTC_1000 4048-0884 8.67 µM 0.742517555944576 0.202087732292447 no 630 0.228886909509986 1081 13040088
SGTC_665 3914-0008 307 µM 0.742403634581871 0.202124012731451 no 631 0.228921409050597 1120 1069549
SGTC_3238 9133470 49.47 µM 0.742365377812655 0.202136197206145 no 632 0.228932995249115 1122 3534688
SGTC_2108 5365811 200 µM 0.742162469626997 0.20220082918543 no 633 0.228994452215059 1139 780283
SGTC_1113 artemisinin 1.17947 µM 0.741910451597126 0.202281121246718 no 634 0.229070796489906 1141 2240 An anti-malaria and mitochondrial poison.
SGTC_2077 5212015 200 µM 0.740998627358225 0.202571784539099 no 635 0.229347136294675 1069 780900
SGTC_1413 3910-0535 34.4 µM 0.73888756087701 0.203245689106091 no 636 0.229987638158713 1136 2876951
SGTC_650 1328-0195 38 µM 0.738694960375709 0.203307238479046 no 637 0.230046123333804 1120 2780821
SGTC_2093 5331342 194.4 µM 0.738525943133844 0.203361260508341 no 638 0.23009745405872 1143 33839
SGTC_164 4100-3994 89.624 µM 0.738013828917431 0.203524996975665 no 639 0.230253022835557 1167 4615967
SGTC_75 0159-0059 199.013 µM 0.737379860083351 0.203727802475463 no 640 0.230445689763787 1113 5377270
SGTC_2742 clothiapine 36.27 µM 0.736996944568825 0.203850354806393 no 641 0.23056210372501 1081 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1464 k208-0027 110 µM 0.73692863915691 0.203872220609946 no 642 0.230582873387529 1121 X1464
SGTC_2828 7998861 71.43 µM 0.733860167708159 0.204855935244926 no 643 0.231516982859936 1055 2988188
SGTC_3224 9130643 49.47 µM 0.73359486583769 0.204941120162862 no 644 0.231597845486175 1159 17644395
SGTC_759 3486-0358 89.3 µM 0.732910849498158 0.205160845874979 no 645 0.231806402695047 1169 875103
SGTC_2073 5212005 126 µM 0.732846745735844 0.205181445018092 no 646 0.23182595335137 1019 691789
SGTC_372 0155-0182 15.9 µM 0.732714247156885 0.205224026089503 no 647 0.23186636628039 1151 771486
SGTC_673 1082-0474 110 µM 0.731150529830922 0.205726954464522 no 648 0.23234360655085 1187 3098046
SGTC_2269 7935389 174.42 µM 0.730227540197021 0.206024152672398 no 649 0.232625555555742 1075 97605
SGTC_1119 parthenolide 318.541 nM 0.727034517587922 0.207054252748969 no 650 0.233602405403228 1206 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_532 1548-0774 215 µM 0.725536250886451 0.207538656644067 no 651 0.234061556976029 1189 5932993
SGTC_294 k038-0071 157 µM 0.725504755006429 0.207548846744269 no 652 0.234071214412246 1151 24152826
SGTC_824 1304-0008 100 µM 0.724682818159257 0.207814878714231 no 653 0.234323319122382 1144 768245
SGTC_2761 levamisole 97.89 µM 0.723009675485971 0.208357037814443 no 654 0.234836969941318 1133 26879 An alkaline phosphatase inhibitor.
SGTC_1931 st074438 57.1 µM 0.722028271586678 0.208675436222946 no 655 0.235138547947869 1138 2787313
SGTC_1211 1056-0033 32.3 µM 0.721892503031117 0.208719506399154 no 656 0.235180285435323 1150 6741922
SGTC_1492 4158-0558 28.5 µM 0.720717328753519 0.209101194564922 no 657 0.235541724254344 1145 3967268
SGTC_2782 7736369 71.43 µM 0.71810946110404 0.209949677865609 no 658 0.236344898503043 1210 2950836 YOL077C BRX1
SGTC_2588 indole-3-carbinol 100 µM 0.716670278370808 0.210418788573555 no 659 0.236788784602779 1152 3712 Induces cell cycle arrest.
SGTC_2960 9079389 5.97 µM 0.716102372976941 0.210604070101554 no 660 0.236964069322417 1140 16457355
SGTC_2770 toltrazuril 17.5 µM 0.715584736504988 0.210773034547337 no 661 0.237123900587929 1164 68591 Kills coccidiodes.
SGTC_465 cgp-37157 41 µM 0.714831037422665 0.211019195547554 no 662 0.237356727075528 1072 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3064 1327-0027 10 µM 0.714789681922837 0.211032707287301 no 663 0.237369505906365 1051 16000455 YPR107C YTH1
SGTC_540 1187-0821 17.3 µM 0.713591473621537 0.211424408118862 no 664 0.237739915715351 1160 847520
SGTC_1575 cyproterone acetate 48 µM 0.711940506503258 0.211964815208788 no 665 0.238250808758866 1136 9880 An androgen receptor antagonist and liver toxin.
SGTC_1366 1683-0113 21.9 µM 0.711579912694003 0.212082954922602 no 666 0.238362474762871 1187 708623
SGTC_1611 st001856 99.4 µM 0.709209883610865 0.212860394407397 no 667 0.239097120505809 1151 647478
SGTC_1116 jasmonic acid 1.58368 µM 0.708592401639068 0.213063219525355 no 668 0.239288726455264 1207 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_874 0599-0792 117 µM 0.70835247969227 0.213142057408155 no 669 0.239363197360456 1209 765305
SGTC_1734 st037168 69.4 µM 0.708080273430288 0.213231524454076 no 670 0.239447704527028 1119 708907
SGTC_2025 5147754 141 µM 0.707780350048613 0.213330126742523 no 671 0.239540835410173 1188 315777 YLR208W SEC13
SGTC_784 4579-0127 173 µM 0.706251756592713 0.213833077288984 no 672 0.240015794583747 1219 1948547
SGTC_1210 3013-0140 750 nM 0.705608614068934 0.214044895603005 no 673 0.240215782930565 1200 905973
SGTC_3107 9121808 49.47 µM 0.703554030905993 0.214722388088588 no 674 0.240855273723842 1143 662681
SGTC_224 benfluorex 43.875 µM 0.701647414435479 0.215352202269938 no 675 0.241449537311415 1190 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_51 1013-0126 23.419 µM 0.701023089179511 0.21555866886717 no 676 0.241644303024904 1248 1627850
SGTC_2176 5809774 33.9695 µM 0.700566520887354 0.215709730280138 no 677 0.241786788928304 1185 2870539
SGTC_3048 9093155 49.47 µM 0.699632122402277 0.216019079125905 no 678 0.242078538239131 1163 25236002
SGTC_3132 9126706 49.47 µM 0.699528186310547 0.216053504849967 no 679 0.242111002229228 1203 850858
SGTC_104 0074-0074 590.992 µM 0.698321182536747 0.216453521449769 no 680 0.24248817747645 1061 3943124
SGTC_1404 3909-7820 48.3 µM 0.698030338922771 0.216549974810609 no 681 0.242579110431952 1171 23741373
SGTC_2444 5485484 36.41 µM 0.697851168433539 0.216609406045854 no 682 0.242635137706891 1219 6790631
SGTC_1086 cerivastatin 2.18 µM 0.69685547573673 0.216939851311886 no 683 0.242946622117351 1157 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1600 coumarin 106 71.1 µM 0.696852016013541 0.216941000014412 no 684 0.242947704806045 1220 100336 A hepatotoxic, DNA x-linker.
SGTC_2862 9027634 71.43 µM 0.696060189435525 0.217203995939371 no 685 0.243195568333584 1153 5012562
SGTC_2155 5570423 76 µM 0.695004435786582 0.217554938468412 no 686 0.243526260851235 1158 797402
SGTC_620 0109-0052 432 µM 0.693946906016537 0.217906799262739 no 687 0.243857753049864 1210 493037
SGTC_937 3122-0005 46.7 µM 0.693026165301972 0.218213414735076 no 688 0.244146565677776 1191 759535
SGTC_2831 7999036 19.48 µM 0.692098728777411 0.218522511155595 no 689 0.244437664973571 1192 2988270
SGTC_2097 5376186 200 µM 0.691732694225146 0.218644572650138 no 690 0.244552605579184 1165 742755
SGTC_1772 st048439 82.2 µM 0.691692630594001 0.218657935046558 no 691 0.244565187956785 1183 2927068 YDL195W SEC31
SGTC_1289 0976-0073 69.1 µM 0.691391297207689 0.218758453634667 no 692 0.244659835845241 1233 3391136
SGTC_3252 9135871 49.47 µM 0.690278625688004 0.219129848153144 no 693 0.245009493359599 1240 17682838
SGTC_1142 3253-1408 9.78 µM 0.689223826511121 0.219482260175504 no 694 0.245341212530327 1190 256655
SGTC_733 4069-0007 56.1 µM 0.689136142717721 0.219511570282043 no 695 0.245368798685631 1231 5717425 YNL287W SEC21
SGTC_3149 9097855 49.47 µM 0.687757979136172 0.219972545024588 no 696 0.245802600986012 1205 25236625 YMR079W SEC14
SGTC_559 1550-0661 158 µM 0.687022083804582 0.220218918120219 no 697 0.246034406060728 1215 5830875
SGTC_2078 5212016 200 µM 0.685689180710017 0.220665568259352 no 698 0.246454565401013 1150 1899708
SGTC_1961 st076550 68.7 µM 0.685547340159184 0.220713128951601 no 699 0.246499299176144 1186 1579337
SGTC_1279 0874-0590 65.2 µM 0.685475802773702 0.220737118448619 no 700 0.246521862338593 1220 3523074
SGTC_440 fluspirilene 35.1 µM 0.68545849089935 0.220742924073313 no 701 0.246527322735643 1262 3396 An atypical antipsychotic.
SGTC_2010 4012422 159 µM 0.685433687702453 0.22075124210334 no 702 0.246535146109086 1181 952393
SGTC_472 calcifediol 10 µM 0.68350155087519 0.221399757250707 no 703 0.247144985273205 1202 5283731 A vitamin D metabolite.
SGTC_1705 st027868 56.3335 µM 0.68264538460999 0.221687474488886 no 704 0.247415474254173 1223 292948
SGTC_350 k064-0020 19.8 µM 0.681493294616173 0.222074974739192 no 705 0.247779704096393 1214 2790705
SGTC_2360 9040895 200 µM 0.680908513007532 0.222271811227172 no 706 0.247964690547003 1179 4914414
SGTC_1950 st077106 7.18 µM 0.680175849047043 0.222518565090869 no 707 0.248196561221192 1199 13831864
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.680017992762925 0.222571749947352 no 708 0.248246534107286 1218 688798
SGTC_2520 obtusaquinone 4.71 µM 0.679709905388968 0.222675571457071 no 709 0.248344081407861 1281 5967872
SGTC_2745 rifampicin 24.3 µM 0.679661248026887 0.222691970890301 no 710 0.248359489276813 1139 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_76 0433-0009 400.328 µM 0.678025150511689 0.22324380030716 no 711 0.248877873382019 1206 2841569
SGTC_3253 9135987 49.47 µM 0.677766838967011 0.223330995731395 no 712 0.248959769891396 1215 4182430
SGTC_1026 k007-1105 30.6 µM 0.677689465208695 0.223357117722759 no 713 0.248984303683232 1227 7066794
SGTC_2786 7743617 45.45 µM 0.676940306704857 0.22361012944111 no 714 0.249221914546795 1150 583674
SGTC_2843 9000894 45.46 µM 0.676226700173195 0.223851285762474 no 715 0.249448361467336 1101 2242070
SGTC_1612 st002233 45.4 µM 0.676069806693973 0.22390432618836 no 716 0.249498162729816 1250 1035021
SGTC_3346 9158254 43.5805 µM 0.674885896111875 0.224304796873953 no 717 0.249874130928516 1200 17639500
SGTC_1891 st059073 26.2 µM 0.673383471825037 0.224813593254391 no 718 0.250351680468456 1277 688754
SGTC_1029 k015-0030 64.7 µM 0.672260233357017 0.225194405356904 no 719 0.250709020606795 1253 2208316
SGTC_1605 st000082 49.1 µM 0.671651782135993 0.22540084136048 no 720 0.25090270224419 1252 1114022
SGTC_2744 captopril 92.04 µM 0.671495755563131 0.225453795483379 no 721 0.250952381235533 1204 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3261 9137475 49.47 µM 0.671175400969214 0.225562543242918 no 722 0.251054398720865 1120 17027690
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.670675272955287 0.225732376327074 no 723 0.25121370922446 1269 688788
SGTC_2175 5807670 165.306 µM 0.669894526772141 0.225997646060754 no 724 0.25146251451796 1200 241186
SGTC_1553 gossypol 38.6 µM 0.669800101793141 0.226029740245292 no 725 0.251492614344248 1166 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_585 0kpi-0023 191 µM 0.668975396727997 0.226310159427 no 726 0.251755586274485 1196 64601
SGTC_1851 st056236 18.9 µM 0.668756954421066 0.226384467872195 no 727 0.251825264817555 1248 5393171
SGTC_1468 k284-1086 134 µM 0.667692098275617 0.226746901749849 no 728 0.252165077464101 1261 15996457
SGTC_1059 3448-6867 171 µM 0.667682675190689 0.226750110446864 no 729 0.252168085600546 1214 3934407
SGTC_530 4358-1714 28 µM 0.66741418746151 0.226841545174744 no 730 0.252253803033439 1255 1564641
SGTC_3166 9102297 49.47 µM 0.665300720288927 0.227562021966499 no 731 0.252929084993855 1207 25237072
SGTC_2463 5473429 200 µM 0.663952596768703 0.228022266917193 no 732 0.253360325540117 1221 5399405
SGTC_3093 9117344 49.47 µM 0.662858516319373 0.228396166941216 no 733 0.253710586154453 1248 24824913
SGTC_1558 st069300 45.6 µM 0.662040315423065 0.228676010638281 no 734 0.253972692347288 1208 24208000
SGTC_1735 st034310 56.75 µM 0.661968362127276 0.228700629542485 no 735 0.253995748988117 1309 871153
SGTC_1930 st074634 34.3 µM 0.660884411772848 0.229071684449824 no 736 0.254343221788281 1224 684253 YOR116C RPO31
SGTC_1663 st014140 55.4 µM 0.660189358959944 0.229309790609355 no 737 0.254566160032076 1317 4207120
SGTC_1708 st033234 31.827 µM 0.659552182081568 0.229528191899795 no 738 0.254770624463613 1317 674664
SGTC_2147 5545932 89.7195 µM 0.65856499666105 0.229866793572035 no 739 0.255087573253978 1250 797404
SGTC_2229 7354935 190 µM 0.658008297516336 0.230057862973323 no 740 0.25526639970058 1202 318112
SGTC_138 0850-0259 40.9225 µM 0.656536457570188 0.230563453389435 no 741 0.255739509023055 1280 6813004
SGTC_2806 7952793 58.44 µM 0.656504849858989 0.230574317732082 no 742 0.255749674047974 1273 2972490
SGTC_1878 temozolomide 1 mM 0.656107415049421 0.230710950198773 no 743 0.255877506893077 1222 5394 DNA alkylating agent.
SGTC_1603 st002045 67.8 µM 0.655350959212264 0.23097113394485 no 744 0.256120909094128 1251 5887985
SGTC_129 0088-0017 176.636 µM 0.655183787230457 0.23102865500821 no 745 0.256174715736011 1187 182446
SGTC_2985 9022375 71.43 µM 0.654972596708073 0.231101333539907 no 746 0.256242698786914 1297 4939335
SGTC_2426 5582046 32.21 µM 0.654516230323114 0.231258429794703 no 747 0.256389637017887 1275 2251934
SGTC_1920 st075728 45.7 µM 0.654385528040849 0.231303432771975 no 748 0.256431727876082 1309 3400306
SGTC_2597 laccaic acid a 100 µM 0.653274140595345 0.231686299323658 no 749 0.256789780215742 1228 5491415 A textile dye.
SGTC_1185 1319-0113 81.3 µM 0.651448091069735 0.232316128928132 no 750 0.257378637620707 1284 4672763
SGTC_254 nsc-64875 3.808 µM 0.651056166424118 0.23245143318627 no 751 0.257505115368542 1290 56993
SGTC_1872 amphotericin b 148 nM 0.650984697713583 0.232476111073497 no 752 0.257528182469564 1258 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2035 5154463 94.595 µM 0.650595187399068 0.232610633181489 no 753 0.257653918917701 1261 2769623
SGTC_2310 7668677 200 µM 0.650462787090209 0.232656369085512 no 754 0.257696665851166 1305 2197143
SGTC_2129 girgensonine 121.053 µM 0.648321513110907 0.233396737079961 no 755 0.258388511252601 1318 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2968 9090663 33.37 µM 0.648021139354384 0.233500698903969 no 756 0.25848563889212 1242 25236811
SGTC_3270 9137563 49.47 µM 0.646940582150778 0.233874900934111 no 757 0.258835199801536 1254 17015724
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.646522515424958 0.23401976850621 no 758 0.258970510237657 1297 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1395 3486-0190 4.35 µM 0.646129578645157 0.234155973404151 no 759 0.259097720524214 1315 6748079
SGTC_3313 9133968 57.047 µM 0.643795037805367 0.234966106993971 no 760 0.259854175982582 1251 1494643
SGTC_2469 5655019 90.81 µM 0.640624852083165 0.236068701652764 no 761 0.260883224481343 1357 2788239
SGTC_912 3474-0017 2.18 µM 0.639840374795453 0.236341983183141 no 762 0.261138190473575 1344 3360550
SGTC_2703 st077852 53.4 µM 0.639512353738065 0.23645630464715 no 763 0.261244839822949 1276 6281836
SGTC_865 0488-0499 301 µM 0.637085339036319 0.237303109595164 no 764 0.262034628866243 1298 9634651
SGTC_1702 st027038 51 µM 0.636738528200072 0.237424250535158 no 765 0.262147586468725 1301 5521182
SGTC_1727 st034309 9.9045 µM 0.634388635778593 0.238245961089433 no 766 0.262913612095325 1363 870305
SGTC_2272 7805186 180 µM 0.633904321122897 0.238415509699906 no 767 0.263071632693614 1278 2956062 YPR165W RHO1
SGTC_3323 9138564 53.9225 µM 0.632964086290957 0.238744855153801 no 768 0.263378547947898 1289 43912313 YNL103W MET4
SGTC_1061 3448-9325 110 µM 0.632708811841916 0.238834315630487 no 769 0.263461907209221 1252 723482
SGTC_3153 9100258 49.47 µM 0.631470565220551 0.239268517019282 no 770 0.26386644468694 1253 25236848
SGTC_712 r015-0009 80.6 µM 0.63107382431189 0.239407728663069 no 771 0.26399612763565 1275 6813872 YLR060W FRS1
SGTC_2659 sanguinarine 24.21 µM 0.630552738943259 0.23959063847564 no 772 0.264166504468127 1253 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2507 purpurin 79.67 µM 0.629526300022265 0.239951158984579 no 773 0.264502278118973 1278 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_3269 9137823 49.47 µM 0.629399452544845 0.239995732694021 no 774 0.264543788150004 1233 17682936
SGTC_1656 st012921 11 µM 0.628910882335051 0.240167456540268 no 775 0.2647037006091 1268 6732821
SGTC_3131 9127911 49.47 µM 0.628774622617494 0.240215361378024 no 776 0.264748308136259 1340 45595681
SGTC_2946 9065502 71.43 µM 0.627878169979521 0.240530657076317 no 777 0.265041876306276 1151 16489101
SGTC_3190 9110366 49.47 µM 0.627506626346522 0.240661400508138 no 778 0.26516359698463 1243 17123768
SGTC_2819 7996655 46.38 µM 0.625914860699618 0.241221968573958 no 779 0.265685393332467 1228 6456960
SGTC_261 5-fluorouridine 15.376 µM 0.625766171393694 0.241274368326608 no 780 0.265734161715988 1331 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1200 1643-0193 18.4 µM 0.625092668049535 0.24151179578594 no 781 0.265955119892475 1290 5403974
SGTC_2345 9052315 157.45 µM 0.623472204319709 0.242083570978447 no 782 0.266487131208693 1312 6469265
SGTC_1047 2043-3044 82 µM 0.623246753587468 0.24216317863831 no 783 0.266561191136321 1279 669592
SGTC_2075 5212009 200 µM 0.622651794186206 0.242373329586804 no 784 0.266756683580288 1277 780898
SGTC_570 0987-0065 62.6 µM 0.622303755773951 0.242496309151071 no 785 0.266871076024225 1206 3104428
SGTC_953 1188-0045 9.7 µM 0.621918196812931 0.242632586072901 no 786 0.266997829562538 1330 6144426
SGTC_1514 1189-1591 158 µM 0.620490764912781 0.24313747672201 no 787 0.267467366113224 1384 767698 YMR146C TIF34
SGTC_634 1611-4317 11.2 µM 0.620024730518282 0.243302438622498 no 788 0.267620752641435 1328 2843522
SGTC_1470 k295-0292 231 µM 0.619726611029299 0.243407995506012 no 789 0.26771889635965 1359 5045612
SGTC_2384 9036245 200 µM 0.619387782843826 0.24352799638917 no 790 0.267830463777782 1354 6462766
SGTC_1263 0774-1208 64.8 µM 0.618767909937757 0.243747615990451 no 791 0.268034632604551 1357 906585
SGTC_1374 2889-5571 141 µM 0.61807317051702 0.243993887643242 no 792 0.268263553455132 1316 2853281
SGTC_1224 0823-0416 294 µM 0.617941888114231 0.244040439783776 no 793 0.268306822849718 1371 3598164
SGTC_1170 0310-0127 64.8 µM 0.617308521688081 0.24426509592119 no 794 0.268515623534691 1338 774975
SGTC_1133 3473-0247 50 µM 0.617187896082586 0.244307894661134 no 795 0.26855539920275 1274 711311
SGTC_547 1120-0019 610 nM 0.616410970447954 0.244583649698039 no 796 0.2688116573485 1318 3676939
SGTC_2238 6671620 73.2395 µM 0.61611564244406 0.244688514735249 no 797 0.268909099399186 1277 729941
SGTC_3086 9117350 49.47 µM 0.614334991773358 0.245321300700301 no 798 0.26949699207735 1252 2679265
SGTC_2038 4100038 30.985 µM 0.614045566511714 0.245424236169527 no 799 0.269592608416325 1333 3596803
SGTC_1064 honokiol 6.76 µM 0.613881517460429 0.245482591298354 no 800 0.269646812233142 1299 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2401 5128683 200 µM 0.613135391233655 0.245748095535777 no 801 0.269893410344318 1257 708373
SGTC_1494 4358-1428 177 µM 0.613077947765213 0.245768542815833 no 802 0.269912400351049 1394 1564571
SGTC_320 4092-0846 5.34 µM 0.611197411183489 0.24643843299991 no 803 0.27053444852278 1333 1359356
SGTC_2296 7971656 126.45 µM 0.611135389016491 0.246460543371295 no 804 0.270554976550039 1328 666570
SGTC_1186 1319-0216 26 µM 0.610579149237426 0.246658885595863 no 805 0.270739114943946 1379 4565136
SGTC_589 1227-0070 34.1 µM 0.608984701003902 0.247227902315097 no 806 0.271267289814142 1332 2841384
SGTC_381 3461-2219 42.7 µM 0.608488259089364 0.247405212589737 no 807 0.271431845313604 1326 2883159
SGTC_1723 st034307 2.5525 µM 0.607531832282512 0.247747003580524 no 808 0.271749012044014 1345 867466
SGTC_611 3453-1652 23.7 µM 0.606839825984917 0.247994457736716 no 809 0.271978607573826 1350 1560575
SGTC_467 ro 31-8220 72.8 µM 0.606807839894238 0.24800589881352 no 810 0.271989222328957 1301 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_3045 9092950 49.47 µM 0.6065047359446 0.248114329778202 no 811 0.272089819220029 1411 44120432
SGTC_1744 st037937 38.9 µM 0.604926525847186 0.248679319534468 no 812 0.272613908642042 1380 1016152
SGTC_1510 1123-0200 71.5 µM 0.604913346908932 0.248684040398452 no 813 0.272618287190953 1438 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2318 6029776 164 µM 0.604592738289212 0.248798901203002 no 814 0.272724816427478 1406 818325
SGTC_3025 9087895 49.47 µM 0.603826102413816 0.249073669599051 no 815 0.272979631707182 1333 17173641
SGTC_1209 2323-2347 50.3 µM 0.603591652121603 0.249157730671072 no 816 0.273057582117005 1319 5412760
SGTC_257 daunorubicin 18.5 µM 0.601780183184046 0.249807732888982 no 817 0.27366023391764 1432 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2184 6075246 200 µM 0.600458895533409 0.250282412513586 no 818 0.274100223523261 1360 2267320
SGTC_1854 st056233 32.9 µM 0.599336181583836 0.250686128997195 no 819 0.274474362418906 1319 5393174
SGTC_1631 benzylvanillin 81.9 µM 0.599140525544077 0.250756520186083 no 820 0.274539589607304 1363 75506
SGTC_2522 biochanin a 4.94 µM 0.598221551209808 0.251087279628454 no 821 0.274846056626633 1324 5280373 A possible chelator.
SGTC_1671 st016596 74.5 µM 0.595928235102544 0.251913701070752 no 822 0.27561158497173 1352 2829167
SGTC_1531 st059297 52.4 µM 0.595667692918601 0.252007681017358 no 823 0.275698622435204 1361 7566702
SGTC_2739 tacrine 100.86 µM 0.595310269163827 0.252136637123209 no 824 0.275818046408971 1350 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_46 0329-0187a 2.197 µM 0.593727872998161 0.252707973000277 no 825 0.276347068649812 1392 46494817
SGTC_1762 st045503 25.4615 µM 0.593703582444479 0.252716748594935 no 826 0.276355193276829 1356 4645554
SGTC_1506 4226-2149 212 µM 0.592954564984679 0.252987429394635 no 827 0.276605779746896 1397 991114
SGTC_1306 1185-0270 9.02 µM 0.592749203834036 0.253061669684328 no 828 0.276674503502489 1354 1548076
SGTC_844 0330-0132 15.3 µM 0.592385551312829 0.253193162138739 no 829 0.276796219715759 1354 2828079
SGTC_2159 5658611 73.75 µM 0.591559530845157 0.25349197482829 no 830 0.277072790076028 1361 793844
SGTC_2738 aclarubicin 5.55 µM 0.590178825664344 0.253991857990328 no 831 0.277535383192876 1323 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2533 agelasine 13.65 µM 0.590153426528819 0.254001058568736 no 832 0.277543896483776 1418 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_504 lovastatin 124 µM 0.586931252788289 0.255169674989388 no 833 0.278624939518262 1313 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_3277 9138724 49.47 µM 0.586177214615993 0.255443554600054 no 834 0.278878215950508 1320 15943418
SGTC_2686 alizarin 95.37 µM 0.585770410422696 0.25559137663133 no 835 0.279014905293271 1326 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_893 0958-0369 48.9 µM 0.584734802887179 0.255967890945595 no 836 0.279363024390604 1428 6819948
SGTC_732 3970-1727 52.7 µM 0.584652576831987 0.255997798147783 no 837 0.279390673688528 1415 1275699
SGTC_377 3970-0964 33.1 µM 0.582751122045562 0.256689902104837 no 838 0.280030426578384 1396 16481235
SGTC_3177 9107506 49.47 µM 0.580131500061895 0.257645002489751 no 839 0.280912971406042 1325 8897194
SGTC_928 2764-0428 58.7 µM 0.579863468185716 0.257742829454601 no 840 0.281003346510691 1426 662578
SGTC_1201 1889-3372 45.9 µM 0.579700507499317 0.257802316689513 no 841 0.281058300532765 1326 5392199
SGTC_958 1222-0007 33 µM 0.577709674327199 0.25852962608514 no 842 0.281730073257036 1457 7312461
SGTC_2158 5657123 3.6195 µM 0.57501695497161 0.259515042963886 no 843 0.282639915117437 1357 2858827
SGTC_1093 fluphenazine 7.97 µM 0.574528308261745 0.259694073880569 no 844 0.282805175023815 1414 6602611 An atypical antipsychotic.
SGTC_2970 9090938 41.86 µM 0.572795513420082 0.260329450601753 no 845 0.283391578622958 1417 17217104
SGTC_2212 7123476 200 µM 0.570755190024456 0.261078616461501 no 846 0.284082800885266 1375 1085715
SGTC_83 0170-0301 39.027 µM 0.57024154365452 0.261267391582272 no 847 0.284256941359822 1354 3089716
SGTC_2834 9001755 58.44 µM 0.568150861571787 0.262036481240837 no 848 0.284966267082363 1415 2989575
SGTC_328 k915-0120 63.5 µM 0.567668217881945 0.262214193903354 no 849 0.285130138079716 1440 6624543
SGTC_2277 7947813 106.88 µM 0.567250025186619 0.262368225189881 no 850 0.285272162476964 1479 1246798
SGTC_942 3253-1115 227 µM 0.56652356627154 0.26263590908669 no 851 0.285518958718183 1473 46497897
SGTC_2856 9022925 19.48 µM 0.563594971506511 0.26371644631827 no 852 0.286514904897649 1410 4944862
SGTC_1500 4488-1866 171 µM 0.563182871616501 0.263868676881733 no 853 0.286655182550738 1478 2900003
SGTC_3353 9151644 39.2805 µM 0.562789033746867 0.264014203271191 no 854 0.286789274291351 1378 4909158
SGTC_2347 9049783 174.81 µM 0.561798151688827 0.264380523298113 no 855 0.287126775776514 1446 6467988 YPL169C MEX67
SGTC_2564 betulinic acid 100 µM 0.561530797420214 0.26447940602721 no 856 0.287217870747673 1545 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1336 1486-0901 104 µM 0.560611384062308 0.264819600674421 no 857 0.287531244592561 1434 5006114
SGTC_1143 3454-2408 5.08 µM 0.560493977754345 0.264863058514603 no 858 0.287571273122519 1350 X1143
SGTC_1222 0366-0074 1.18 µM 0.55992848769077 0.265072424922565 no 859 0.287764108309262 1445 286520
SGTC_2536 dehydroabietamide 32.04 µM 0.55983522963198 0.265106960755487 no 860 0.287795915681518 1491 3983547
SGTC_151 3013-0144 2.285 µM 0.558598324395586 0.265565234324051 no 861 0.288217941917632 1471 906558 YHR107C CDC12
SGTC_565 1418-0001 44.5 µM 0.558037801230191 0.265773040461741 no 862 0.288409285849602 1441 2862145
SGTC_2061 5245884 80.95 µM 0.557606792253988 0.265932887062829 no 863 0.288556458666353 1382 573863
SGTC_761 k216-0224 480 µM 0.556650703040934 0.266287641885502 no 864 0.288883052221638 1515 1340404
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.556323764013693 0.266409006832924 no 865 0.28899477226572 1432 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_863 0466-0191 129 µM 0.556305613896515 0.266415745263859 no 866 0.289000975032622 1398 765160 YPR165W RHO1
SGTC_105 0111-0055 734.78 µM 0.555627310647082 0.266667634628721 no 867 0.289232828730108 1379 5179370
SGTC_1096 rimcazole 32.2 µM 0.554894508268411 0.266939897591456 no 868 0.289483409216502 1361 18528119 A dopamine reuptake inhibitor.
SGTC_2348 9022543 33.42 µM 0.554779637890989 0.266982588876788 no 869 0.289522698182553 1430 3162678 YDL140C RPO21
SGTC_2976 9009005 19.48 µM 0.554774784869364 0.266984392565921 no 870 0.289524358110367 1516 2993148
SGTC_2800 7887935 81.82 µM 0.554608373343349 0.267046245315454 no 871 0.289581280222805 1440 2961002
SGTC_52 0329-0193 875 nM 0.553714264852331 0.267378696299733 no 872 0.289887205592506 1479 3739292
SGTC_3063 1327-0034 4 µM 0.552998156920524 0.267645112893327 no 873 0.290132336112229 1331 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2338 7999974 200 µM 0.552825549036626 0.267709348924252 no 874 0.290191435948984 1461 315925
SGTC_1984 st072354 53.1 µM 0.552791874553414 0.267721881790182 no 875 0.290202966534405 1399 5762938
SGTC_1867 st057372 64 µM 0.552449065419039 0.267849484266018 no 876 0.290320361098537 1399 688837
SGTC_1621 st003705 32.4 µM 0.551690156628944 0.268132078794834 no 877 0.290580327558207 1476 24207032
SGTC_889 0919-1524 82.7 µM 0.549392210497832 0.268988678049731 no 878 0.29136815929302 1384 3905452
SGTC_941 3237-0776 460 µM 0.549161348283395 0.269074811816782 no 879 0.291447363548906 1487 760008
SGTC_1007 4101-0031 70 µM 0.547568747924049 0.269669381464381 no 880 0.291994026636672 1470 1146276
SGTC_255 tunicamycin 200.472 nM 0.547419084846079 0.269725289382167 no 881 0.292045423301964 1427 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1295 1013-0063 9.78 µM 0.54714563658195 0.269827453301321 no 882 0.292139340630832 1463 6826038
SGTC_3162 9099653 49.47 µM 0.547071649975653 0.269855099014278 no 883 0.292164754158401 1400 25237511
SGTC_569 4130-2812 160 µM 0.546881147569743 0.269926288353872 no 884 0.292230194224297 1381 743552
SGTC_326 k292-0812 17.5 µM 0.542696237328785 0.271492525771502 no 885 0.293669482660376 1430 3579357
SGTC_507 nimesulide 162 µM 0.542675651564677 0.271500241338907 no 886 0.293676570688803 1478 4495 A COX2 inhibitor.
SGTC_2825 7998094 58.44 µM 0.542669519073228 0.271502539824672 no 887 0.293678682225135 1434 2987815
SGTC_3354 9151612 71.43 µM 0.542492253678201 0.271568983892191 no 888 0.29373972119273 1483 27261949
SGTC_534 k292-0788 63.4 µM 0.541742790585961 0.271849993248469 no 889 0.293997853641243 1485 4146317
SGTC_621 3584-0052 32.1 µM 0.541508029484785 0.27193804609763 no 890 0.294078732367748 1445 2273927
SGTC_3237 9133362 49.47 µM 0.541429191033112 0.271967619554244 no 891 0.294105895705353 1462 43845137
SGTC_1686 st019653 115.5 µM 0.540284132728907 0.272397327925602 no 892 0.29450054965307 1489 97252
SGTC_1690 st023502 41.2 µM 0.53953899475694 0.272677138388678 no 893 0.294757498904611 1486 24207482
SGTC_676 falcarinol 140 µM 0.538933417373944 0.272904646781186 no 894 0.294966398967159 1545 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_3271 9137798 49.47 µM 0.538276478243678 0.273151557589118 no 895 0.295193093893174 1453 6498326
SGTC_2476 5806916 10.51 µM 0.537786290231086 0.273335867017946 no 896 0.295362298993611 1429 2870194
SGTC_1788 fluconazole 20 µM 0.53724942233938 0.273537798602714 no 897 0.29554766843011 1415 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1161 k007-0610 110 µM 0.536974891890499 0.273641085989979 no 898 0.295642478811309 1478 5843850
SGTC_1371 2421-0008 32.7 µM 0.53621832464553 0.273925831307073 no 899 0.295903835189245 1446 2827552
SGTC_2829 7992743 58.44 µM 0.535230588007571 0.274297800958363 no 900 0.296245208691605 1479 16462845
SGTC_1357 1503-1303 39.5 µM 0.535063064484143 0.274360913014898 no 901 0.296303124720447 1443 292895
SGTC_1797 st048695 56.8 µM 0.534950154897352 0.274403454106805 no 902 0.296342162614304 1472 592262 YIL048W NEO1
SGTC_2839 9003951 25.97 µM 0.534528314315292 0.274562420330497 no 903 0.296488032628588 1437 2990634
SGTC_2808 7946468 45.46 µM 0.533728284347247 0.274864028010399 no 904 0.296764768664992 1477 2970879
SGTC_622 1348-1566 26.3 µM 0.533302647232054 0.275024557799762 no 905 0.296912047735559 1506 7340407
SGTC_444 curcumin 90.4 µM 0.532286159304214 0.275408114767158 no 906 0.297263908398982 1435 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2748 diazoxide 86.69 µM 0.530018050284428 0.276264900440134 no 907 0.298049707973836 1452 3019 A potassium channel activatior.
SGTC_2215 7188065 200 µM 0.529326715599014 0.276526314234421 no 908 0.298289412995671 1469 940217
SGTC_1043 0916-0009 19.3 µM 0.528024092008341 0.277019203465229 no 909 0.298741307263149 1567 3101130
SGTC_819 1013-0258 27.7 µM 0.527609385531719 0.277176211101575 no 910 0.298885238719905 1433 5753198
SGTC_506 n9-isopropylolomoucine 153 µM 0.527223747935409 0.277322252331933 no 911 0.299019109553098 1549 6610355
SGTC_384 k007-0144 5.16 µM 0.526844424027169 0.277465939264001 no 912 0.299150815199075 1471 6824886
SGTC_2295 7971645 200 µM 0.524057368383005 0.278522783358145 no 913 0.300119319480232 1504 2978226 YKL099C UTP11
SGTC_222 nsc-310342 10.666 µM 0.524008404095603 0.278541367999487 no 914 0.300136347282532 1474 432556
SGTC_468 gf-109203x 121 µM 0.523639985971069 0.278681222317831 no 915 0.300264482240832 1415 2396 A protein kinase C inhibitor.
SGTC_2913 7966556 36.57 µM 0.521102647127667 0.279645342887859 no 916 0.301147633499592 1496 2976516
SGTC_352 k048-0007 5.11 µM 0.520518893520212 0.279867382424319 no 917 0.301350981442434 1422 6811911
SGTC_1320 1313-0481 95.3 µM 0.51885613747795 0.280500305145443 no 918 0.30193053356159 1479 6813365 YLR208W SEC13
SGTC_2647 atorvastatin 60.16 µM 0.518242996720317 0.280733869906762 no 919 0.302144369517327 1496 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1654 st012436 41.8 µM 0.518121001158077 0.280780353102582 no 920 0.302186924197586 1457 4323132
SGTC_3328 9140624 29.0385 µM 0.515746651315261 0.281685776907432 no 921 0.303015683638273 1556 4904392
SGTC_68 0986-0284 82.829 µM 0.514517152950765 0.28215518079085 no 922 0.303445235513082 1395 423278 YIL048W NEO1
SGTC_2948 9070189 9.45 µM 0.513884865237325 0.282396725207252 no 923 0.303666244783671 1510 6473636 YDL196W YDL196W
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.513844557298292 0.282412126881763 no 924 0.303680336419868 1527 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1716 st033144 30.6155 µM 0.5133722726575 0.282592617065711 no 925 0.303845468644491 1535 674617
SGTC_2859 9028643 45.46 µM 0.512485923079493 0.282931497562587 no 926 0.304155484903126 1437 17151580
SGTC_1032 k061-1018 98.7 µM 0.512263477445189 0.283016576440172 no 927 0.304233311270037 1611 4005393
SGTC_2645 abamectin 100 µM 0.51158193414789 0.283277323025677 no 928 0.304471815919712 1478 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_700 3453-2283 142 µM 0.510014004629822 0.283877622570862 no 929 0.305020825206949 1532 565664
SGTC_1607 st000305 50.6 µM 0.509703200848355 0.283996689585856 no 930 0.305129705097349 1511 5457690
SGTC_894 0960-0238 55.9 µM 0.508724019127662 0.284371964216359 no 931 0.305472841976073 1481 6741907 YDL195W SEC31
SGTC_1355 1499-0035 1.68 µM 0.508327784396741 0.284523889804754 no 932 0.305611744018793 1442 1548538
SGTC_646 4092-0839 27.3 µM 0.507858797697077 0.284703760267175 no 933 0.3057761857801 1542 877796
SGTC_554 4483-2211 187 µM 0.506798285617566 0.285110698472785 no 934 0.306148179685846 1476 747107
SGTC_2252 omeprazole 400 µM 0.50631940588591 0.285294544354281 no 935 0.306316221024296 1512 4594 A proton pump inhibitor.
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.505744467715843 0.285515342438581 no 936 0.306518023585718 1461 17037758
SGTC_1810 st050138 53 µM 0.505145365308096 0.285745507018168 no 937 0.306728370201599 1491 3444541
SGTC_2458 5808907 16.39 µM 0.505083506724688 0.285769277020962 no 938 0.306750092559257 1487 2731747
SGTC_3292 9120825 59.784 µM 0.504150631930375 0.286127860848533 no 939 0.307077764602954 1543 24824900
SGTC_2333 9017922 200 µM 0.504001761563415 0.286185104275576 no 940 0.307130069550549 1610 3163164
SGTC_515 4092-1064 102 µM 0.501919268276821 0.286986431388285 no 941 0.307862155439957 1592 717353
SGTC_1726 st035556 14.5795 µM 0.501878541021111 0.287002113507732 no 942 0.307876480461311 1575 5919439
SGTC_1175 0741-0056 27.6 µM 0.501719747063268 0.287063261346812 no 943 0.307932335948802 1572 765927
SGTC_2219 9098279 200 µM 0.499417591316029 0.287950460008827 no 944 0.308742614476052 1513 902349
SGTC_319 1348-1596 45.5 µM 0.498206312169726 0.28841777872407 no 945 0.309169316940247 1594 5380505
SGTC_1330 1469-0054 61.8 µM 0.498202329460506 0.288419315866525 no 946 0.3091707203713 1598 7102664
SGTC_2909 7941780 10.49 µM 0.498044972244308 0.288480051599802 no 947 0.30922617229266 1523 1243215
SGTC_669 0108-0021 26.2 µM 0.498005766225596 0.288495185026428 no 948 0.309239988980234 1755 17201
SGTC_3201 9113999 49.47 µM 0.497910755817005 0.288531860361844 no 949 0.309273472946367 1561 16649224
SGTC_2514 salinomycin 42.74 µM 0.497338111458129 0.288752955536804 no 950 0.309475320207206 1608 23682228 A polyether potassium ionophore.
SGTC_3199 9111318 49.47 µM 0.49712238324007 0.28883626782352 no 951 0.309551375595759 1537 8548020
SGTC_2628 lathosterol 100 µM 0.496629614782015 0.289026612973596 no 952 0.3097251326328 1521 6710616
SGTC_1715 st032160 10.2275 µM 0.495902403386666 0.289307625796547 no 953 0.30998163520361 1529 5289825
SGTC_1073 triclabendazole 3.09 µM 0.495261443832552 0.289555415141151 no 954 0.310207791670072 1518 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2067 5224629 34.075 µM 0.494769690382918 0.289745590243136 no 955 0.310381350865568 1459 2835000
SGTC_993 3909-8757 62.7 µM 0.493190163193769 0.290356834642503 no 956 0.310939113863929 1501 4288324 YLR208W SEC13
SGTC_791 1348-1292 225 µM 0.492295112018558 0.290703468761159 no 957 0.31125536754626 1516 5437054
SGTC_2697 mebhydrolin 72.4 µM 0.492213949604818 0.290734910791122 no 958 0.311284052033434 1614 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1790 st045711 43.5 µM 0.491681552480851 0.290941198960324 no 959 0.311472240670319 1621 585119
SGTC_3218 9131285 49.47 µM 0.490744508154024 0.291304442016176 no 960 0.311803581289345 1640 17156417
SGTC_1412 3909-8563 178 µM 0.490113933642815 0.291549001841395 no 961 0.312026639410448 1593 23767530
SGTC_2973 9094665 17.96 µM 0.488757092259062 0.292075558880474 no 962 0.31250683937663 1608 25237061 YIL048W NEO1
SGTC_2467 5474540 200 µM 0.488697699896791 0.29209861771603 no 963 0.312527866219842 1454 5413519
SGTC_2991 9074669 71.4286 µM 0.488450391057653 0.292194643443896 no 964 0.312615428217082 1591 17333109
SGTC_774 k060-0086 136 µM 0.48842124198949 0.29220596248844 no 965 0.312625749413019 1559 5911235
SGTC_1004 4084-0029 199 µM 0.487803812199904 0.292445768159329 no 966 0.312844405451832 1581 716894 YLR208W SEC13
SGTC_5 0352-0601 109.883 µM 0.487271666755504 0.292652523325671 no 967 0.313032911817756 1479 762456
SGTC_439 amiodarone 34.4 µM 0.485804173121218 0.293223042071995 no 968 0.313553007624547 1578 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_3299 9121982 43.1275 µM 0.485245797767801 0.293440257471349 no 969 0.313750999424158 1487 17594604 YPL160W CDC60
SGTC_102 gallobenzophenone 83.616 µM 0.482974061013444 0.294324760722874 no 970 0.314557077010029 1586 70837
SGTC_356 1634-0012 32.5 µM 0.482325455903904 0.294577521608816 no 971 0.314787383302715 1548 735457
SGTC_171 k064-0041 9.68 µM 0.481730579393539 0.294809432515962 no 972 0.314998675033516 1442 53325
SGTC_3061 glucosamine 200 µM 0.48133202702079 0.294964854089763 no 973 0.315140269085984 1542 91431 and experimental redox chemotherapeutic
SGTC_658 3253-0951 102 µM 0.480697315306506 0.295212447503905 no 974 0.315365819748122 1531 1184878
SGTC_1855 st056195 39.6 µM 0.479623436062881 0.295631572623365 no 975 0.315747589342012 1590 4028379
SGTC_907 3448-6986 75.5 µM 0.478129065286913 0.296215266390628 no 976 0.316279173047714 1616 590582
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.477590649956865 0.296425698199285 no 977 0.316470793515796 1475 390807
SGTC_979 1426-2828 121 µM 0.476324267098033 0.296920915453726 no 978 0.316921689725659 1593 747872
SGTC_1679 SEC14.276 6.7 µM 0.475216609494512 0.297354373507963 no 979 0.317316294806615 1631 1005053 YMR079W SEC14
SGTC_1205 4161-2785 76 µM 0.475043436553563 0.297422167147422 no 980 0.317378006778771 1444 3498106
SGTC_3314 9135860 59.4275 µM 0.474915549998331 0.297472236630726 no 981 0.317423583737165 1531 25252478
SGTC_964 1287-0107 19.4 µM 0.473900583011062 0.297869747680322 no 982 0.317785401726264 1622 51516812 YPR165W RHO1
SGTC_191 3914-0123 66.505 µM 0.473773223414991 0.297919645068503 no 983 0.317830815493919 1452 3144412
SGTC_1003 4049-0218 100 µM 0.472102747022999 0.298574462621316 no 984 0.318426725903932 1589 295161
SGTC_1906 st060206 94.7 µM 0.472086674758515 0.298580766038887 no 985 0.318432461661528 1597 5133468
SGTC_2524 avocatin b 10.57 µM 0.471689753981408 0.298736454491776 no 986 0.318574125784577 1584 6710748
SGTC_522 1273-0010 11.6 µM 0.471592844251939 0.298774472028351 no 987 0.318608717652737 1559 5705015
SGTC_751 0833-0568 350 µM 0.470846932409254 0.299067165655948 no 988 0.318875023320789 1566 6954252
SGTC_2519 cryptotanshinone 88.04 µM 0.469922791060698 0.299429976464605 no 989 0.319205090271419 1590 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_106 0092-0003 11.579 µM 0.469434945332565 0.29962158140297 no 990 0.319379387415001 1607 1072148
SGTC_770 0389-1121 67.2 µM 0.46912418079667 0.299743665380134 no 991 0.319490437944186 1630 6753108
SGTC_1291 0993-0025 5.79 µM 0.468701912358631 0.299909589805832 no 992 0.319641359915845 1609 4353356
SGTC_2620 irigenin 100 µM 0.46794914180042 0.300205483440603 no 993 0.319910479956137 1640 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1499 4480-0877 67.3 µM 0.467752281598983 0.300282885598819 no 994 0.319980874317154 1527 2861909
SGTC_1203 3992-3522 103 µM 0.466267229285088 0.300867073928516 no 995 0.320512116294115 1752 5322312
SGTC_671 0560-0003 407 µM 0.464544440851468 0.301545424143749 no 996 0.321128863678049 1566 3238678
SGTC_3118 9124250 49.47 µM 0.463569915149303 0.301929449374901 no 997 0.321477956480634 1498 1504786
SGTC_959 1222-0044 107 µM 0.462965907612825 0.302167577074461 no 998 0.321694402146825 1602 6083612
SGTC_2041 5107442 45.335 µM 0.462679224259165 0.302280630402485 no 999 0.32179715610856 1611 793005
SGTC_358 0075-0058 9.45 µM 0.461271028567107 0.302836226477176 no 1000 0.322302083886965 1752 1069125
SGTC_2150 5556613 200 µM 0.460883720361389 0.302989116994278 no 1001 0.322441016089491 1570 743190
SGTC_2127 5253358 187.912 µM 0.460846327175578 0.303003879840856 no 1002 0.322454430796887 1477 20612
SGTC_2746 daunorubicin 9.88 µM 0.460781030339777 0.303029659832742 no 1003 0.32247785641986 1558 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_898 1000-0849 28.3 µM 0.460262744910999 0.30323432007857 no 1004 0.322663819352096 1552 6751807
SGTC_216 k038-0035 28.382 µM 0.459854022334069 0.303395759779692 no 1005 0.322810501976197 1530 4444231 YPR107C YTH1
SGTC_1405 3909-7894 12 µM 0.459766410433497 0.303430370252755 no 1006 0.322841947781231 1623 7104060
SGTC_839 0122-0028 230 µM 0.458051564071726 0.304108163224441 no 1007 0.323457698011764 1548 759448
SGTC_1509 1326-1131 80 µM 0.457964512628748 0.304142588292603 no 1008 0.323488968507584 1588 768313
SGTC_1529 apigenin 74 µM 0.456499612941599 0.304722152802551 no 1009 0.324015374552067 1629 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_360 0957-0399 1.01 µM 0.455085804008548 0.305281969212383 no 1010 0.324523755272447 1639 6752301 YPR165W RHO1
SGTC_1329 1447-1697 50.6 µM 0.454606618354922 0.305471812613055 no 1011 0.324696136252818 1528 2840515
SGTC_2933 9026794 32.47 µM 0.453207443165586 0.306026436034597 no 1012 0.325199686648187 1597 17586027
SGTC_2736 butenafine 14.65 µM 0.451666930976359 0.306637599195322 no 1013 0.325754472349017 1614 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2525 harmine 47.85 µM 0.451623610682364 0.306654793321939 no 1014 0.325770078902953 1620 5280953 A monoamine oxidase inhibitor
SGTC_790 1575-0012 79.1 µM 0.451506037998778 0.306701460884004 no 1015 0.325812437135576 1586 378741 YLR208W SEC13
SGTC_113 0099-0221 2.5 µM 0.451412557320105 0.306738567958298 no 1016 0.325846117280338 1641 89219
SGTC_3069 9117009 49.47 µM 0.451210740919021 0.306818685557239 no 1017 0.325918834538251 1511 41904981
SGTC_2200 6600604 21.907 µM 0.448813012083889 0.307771247466145 no 1018 0.326783275646834 1514 2904777
SGTC_2396 5342950 42.78 µM 0.448063884011223 0.308069124879641 no 1019 0.327053546032883 1552 1886677
SGTC_2629 bisabolol 100 µM 0.448017422577981 0.308087603607052 no 1020 0.327070311375716 1632 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1866 st057638 64 µM 0.44719569164745 0.30841450431514 no 1021 0.327366885930295 1559 688802
SGTC_32 0928-0142 34.1 µM 0.446124290915003 0.30884095678934 no 1022 0.327753733609469 1579 2244242
SGTC_968 1309-0633 340 µM 0.44572935632513 0.308998218724996 no 1023 0.32789637821367 1607 3761976
SGTC_413 propylparaben 100 µM 0.445021462385336 0.309280187883991 no 1024 0.328152121998386 1514 7175 A pharmaceutical preservative.
SGTC_2438 5259590 200 µM 0.444928984846894 0.30931703194875 no 1025 0.328185537696035 1672 1201127
SGTC_2549 cedrol 20.94 µM 0.444671466244003 0.309419640284701 no 1026 0.328278596333606 1612 6708665 A sedative which affects the nervous system.
SGTC_2504 purpurogallin 52.29 µM 0.444130562184694 0.309635211991735 no 1027 0.32847409572178 1542 5281571 An antioxidant.
SGTC_3116 9124943 49.47 µM 0.443277117543649 0.309975476698669 no 1028 0.328782652407491 1474 41905195 YPL160W CDC60
SGTC_1489 4065-0444 182 µM 0.441016903960554 0.310877400156463 no 1029 0.32960037970148 1662 2877968
SGTC_1912 st060209 90.8 µM 0.440138484363739 0.311228234983578 no 1030 0.329918405169843 1504 688787
SGTC_702 1488-0190 94 µM 0.439995488081134 0.311285362973759 no 1031 0.329970187585424 1673 949357
SGTC_3349 9149703 23.001 µM 0.439595387197168 0.311445230153891 no 1032 0.330115091109989 1523 4910494
SGTC_1350 1495-0454 146 µM 0.436702521988799 0.312602180670914 no 1033 0.331163550002305 1640 1069057
SGTC_974 1326-0144 138 µM 0.435922036487687 0.312914639329721 no 1034 0.331446648081477 1551 5411856
SGTC_1121 fusaric acid 630.51 nM 0.435445194334074 0.313105603939524 no 1035 0.331619655915011 1552 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3071 9117417 49.47 µM 0.43425341322573 0.313583104780837 no 1036 0.332052214882083 1657 45595590 YGL055W OLE1
SGTC_3101 9120531 49.47 µM 0.433599955196241 0.313845052990362 no 1037 0.332289483658325 1652 24824904
SGTC_1430 4049-0248 69.1 µM 0.432448821509901 0.314306730003595 no 1038 0.332707620566932 1669 22774488
SGTC_809 3998-0021 90 µM 0.431941795065848 0.314510171743566 no 1039 0.332891858534858 1635 715485
SGTC_727 3032-0951 202 µM 0.431907341611179 0.314523998059012 no 1040 0.332904379335636 1613 3652836
SGTC_1958 st076513 41.9 µM 0.430560188001692 0.315064820213634 no 1041 0.333394097148655 1533 732122 YGL099W LSG1
SGTC_2999 9069765 71.4286 µM 0.430076521377958 0.315259087655466 no 1042 0.33356998918749 1648 2097066
SGTC_745 0469-0705 296 µM 0.429035436252943 0.315677418700829 no 1043 0.333948718258834 1703 3486736
SGTC_3259 9138485 49.47 µM 0.427429472943213 0.316323193530742 no 1044 0.334533272110738 1677 17646153
SGTC_856 0433-0016 11.3 µM 0.427236433126872 0.316400854659367 no 1045 0.33460356363379 1586 3911780
SGTC_1118 chelidonine 707.474 nM 0.427077052075809 0.31646498075848 no 1046 0.334661603371402 1714 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2515 chrysin 20.77 µM 0.425604209450777 0.31705783188564 no 1047 0.335198136225008 1664 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2857 9024691 58.44 µM 0.423764873692452 0.317798864239267 no 1048 0.335868648933198 1586 16478292
SGTC_505 gw-5074 63.9 µM 0.423293218683576 0.317989002576783 no 1049 0.336040670668635 1668 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1081 sertraline 6 µM 0.423157912359366 0.318043557490881 no 1050 0.336090025852475 1684 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2351 9026858 72.31 µM 0.423079621967212 0.318075125635607 no 1051 0.336118584837855 1511 1409300
SGTC_2570 licareol 100 µM 0.42123966209254 0.318817411875237 no 1052 0.336790042532239 1560 443158
SGTC_198 3454-2873 16.191 µM 0.421082665670622 0.318880781916276 no 1053 0.336847359466548 1612 710957
SGTC_1968 st069590 43.6 µM 0.421071090765163 0.318885454221123 no 1054 0.33685158543321 1669 6384066
SGTC_389 tpck 16.7 µM 0.420700968143025 0.3190348724037 no 1055 0.336986727057737 1597 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_637 1181-0519 7.26 µM 0.419006635150839 0.319719248332806 no 1056 0.337605641589416 1582 6252091 YGR060W ERG25
SGTC_3215 9129942 49.47 µM 0.418963769375985 0.319736570676917 no 1057 0.337621305523622 1688 17682944
SGTC_2102 5377816 72.7585 µM 0.418621809877565 0.319874772856981 no 1058 0.337746273818835 1719 1379702
SGTC_221 trifluoperazine 10.304 µM 0.418369828576622 0.319976626549766 no 1059 0.337838371242663 1589 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_206 4546-0025 72.014 µM 0.417872599292908 0.320177652059712 no 1060 0.338020133587954 1599 6620745 YIL048W NEO1
SGTC_1704 st028805 70.8 µM 0.416476199312267 0.3207424867044 no 1061 0.338530789969748 1589 2876101
SGTC_1050 3232-1156 69.3 µM 0.415037673617057 0.321324795198386 no 1062 0.339057162147975 1568 700529
SGTC_802 4112-3352 742 µM 0.413574896281348 0.32191737134518 no 1063 0.339592730614186 1706 704594
SGTC_2436 5633522 8.09 µM 0.41268007174905 0.322280091349106 no 1064 0.339920513654105 1727 5724242
SGTC_1967 st070177 51.4 µM 0.41207437359903 0.322525709146789 no 1065 0.340142455574303 1656 5729214
SGTC_1636 st007707 68.9 µM 0.411247539945686 0.322861125076895 no 1066 0.34044551611856 1719 403051
SGTC_2068 5226020 147 µM 0.410399237350133 0.323205399978652 no 1067 0.340756552821177 1570 1810509
SGTC_789 1309-1135 70.6 µM 0.409825055593408 0.32343851173471 no 1068 0.340967142473573 1564 3092424
SGTC_2198 6589944 200 µM 0.409136601747145 0.323718108142599 no 1069 0.341219708437166 1658 5290268
SGTC_624 k048-0052 28 µM 0.407004324924717 0.324584704058852 no 1070 0.342002405850415 1613 6835531
SGTC_1212 0520-0165 585 µM 0.406761577132127 0.324683421513117 no 1071 0.342091554715213 1811 5403258
SGTC_1540 guanosine 70.6 µM 0.406502363282869 0.32478884876284 no 1072 0.342186760440417 1676 6802 Guanosine is a purine nucleoside
SGTC_1898 st060199 18.6 µM 0.404553927058751 0.325581763990745 no 1073 0.342902715350224 1585 688866
SGTC_3225 9130819 49.47 µM 0.404534257738845 0.325589772444555 no 1074 0.342909945744457 1654 4547121
SGTC_2193 5925765 200 µM 0.404504759440857 0.325601782962775 no 1075 0.342920789355003 1673 877370
SGTC_1987 st072290 61.9 µM 0.404270742060712 0.325697071824587 no 1076 0.3430068190154 1643 54697379
SGTC_3100 9120536 49.47 µM 0.402758819916029 0.32631298131848 no 1077 0.343562829060949 1678 16421196
SGTC_252 miconazole 1.30953 nM 0.401520935296566 0.326817609531249 no 1078 0.344018313895671 1636 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2679 rapamycin 1 nM 0.401083153944215 0.326996148616004 no 1079 0.344179451612725 1640 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_3014 9081533 49.47 µM 0.397774210205938 0.328346904019682 no 1080 0.345398314632854 1742 21367265
SGTC_3213 9129884 49.47 µM 0.39703351716223 0.328649573304466 no 1081 0.345671372250229 1494 17190742
SGTC_657 3534-0529 86.7 µM 0.396981918440008 0.328670662274055 no 1082 0.345690397191404 1732 1049549
SGTC_3111 9122088 49.47 µM 0.396972476510657 0.328674521354277 no 1083 0.34569387856302 1712 16876704
SGTC_2557 derrustone 83.84 µM 0.396462139541427 0.328883132093904 no 1084 0.345882066358792 1573 629853 An antioxidant.
SGTC_542 3381-0244 89.3 µM 0.395484753455921 0.329282807570475 no 1085 0.346242585732526 1734 1112843
SGTC_561 1550-0330 72.9 µM 0.395115654794161 0.329433791229605 no 1086 0.346378768017728 1597 6812934
SGTC_577 r071-0003 38.6 µM 0.394454775824689 0.329704200140073 no 1087 0.346622654892365 1588 4568517 YMR134W ERG29
SGTC_593 1203-0218 61.7 µM 0.394313649607652 0.329761955669351 no 1088 0.346674743520695 1735 3666956
SGTC_2678 equilin 100 µM 0.394294515141525 0.329769786711304 no 1089 0.346681806131816 1727 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_204 PMA1.184 62.41 µM 0.392946151340719 0.330321810772364 no 1090 0.347179626873801 1645 2252213 YGL008C PMA1
SGTC_2239 6685329 187.64 µM 0.392743232377662 0.330404918400898 no 1091 0.347254568140193 1624 805680
SGTC_2371 9071574 200 µM 0.39251113757979 0.330499985560034 no 1092 0.347340291838304 1696 45596039
SGTC_1284 0929-0043 16 µM 0.392483898707031 0.330511143452244 no 1093 0.347350352967601 1621 1239883
SGTC_410 α-linolenic acid 100 µM 0.392255202478511 0.330604830505029 no 1094 0.347434829953647 1712 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2531 methyl deoxycholate 70.07 µM 0.391532802148114 0.330900836688153 no 1095 0.347701723654058 1584 16667744 Haematoxylin.
SGTC_848 0368-0089 85.6 µM 0.391424979617131 0.330945026439566 no 1096 0.347741565598958 1699 762535
SGTC_3073 9114972 49.47 µM 0.390740767356437 0.331225497378764 no 1097 0.347994430848274 1749 41905075
SGTC_1435 4092-0789 56.7 µM 0.390458407373118 0.331341269441376 no 1098 0.348098802722856 1736 2248285
SGTC_1249 0481-0015 10.2 µM 0.390437822275807 0.331349710287686 no 1099 0.348106412272451 1593 4227577
SGTC_2747 doxorubicin 7.63 µM 0.390352060014467 0.331384877721453 no 1100 0.34813811606862 1686 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_724 3910-0327 137 µM 0.389397191672664 0.331776528744577 no 1101 0.348491174577817 1598 2885483
SGTC_1322 1348-1070 12 µM 0.38934325316039 0.331798657782667 no 1102 0.348511122033846 1644 6758089
SGTC_2003 4023581 200 µM 0.387897332305698 0.33239208579806 no 1103 0.349046006190664 1645 16641307
SGTC_218 alverine citrate 93.75 µM 0.386612633021981 0.332919698798203 no 1104 0.34952150203721 1711 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2000 st075254 36.4 µM 0.386187247433954 0.33309447334782 no 1105 0.349678998819324 1619 17234175
SGTC_2927 9011802 47.9 µM 0.38598854252516 0.333176125965763 no 1106 0.349752577137171 1570 43912568
SGTC_181 1447-1644 8.07 µM 0.383741287579219 0.334100126644984 no 1107 0.350585104019533 1750 534600
SGTC_2684 capsaicin 100 µM 0.383624663209901 0.334148106442067 no 1108 0.35062832877632 1673 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2473 5854593 8.94 µM 0.383516812673633 0.334192479056494 no 1109 0.350668303388458 1637 2872951
SGTC_2116 5511452 16.8835 µM 0.383323477468183 0.334272028165699 no 1110 0.350739966881821 1670 870744
SGTC_811 0416-0114 265 µM 0.382643957211716 0.334551680520365 no 1111 0.350991886542662 1650 6612453
SGTC_1141 3253-0389 52.6 µM 0.381910936672282 0.334853453531559 no 1112 0.351263713899428 1731 5402031
SGTC_2281 7943571 200 µM 0.380431493967767 0.335462841550899 no 1113 0.3518125700498 1799 1244024
SGTC_29 0299-0004 12.984 µM 0.378680997510658 0.336184436994579 no 1114 0.352462383032218 1636 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2255 7941087 197.44 µM 0.376513082344158 0.337078939266083 no 1115 0.353267745759283 1791 935561
SGTC_1983 st071813 46.9 µM 0.376465302941638 0.337098663900741 no 1116 0.35328550283463 1669 11838595
SGTC_2359 9039622 200 µM 0.376241651636066 0.337190999186296 no 1117 0.35336862643511 1730 6463596
SGTC_2254 7938975 95.19 µM 0.376027716081704 0.337279332465871 no 1118 0.353448145566314 1762 2969277
SGTC_2189 6047310 154.431 µM 0.375588299093511 0.337460794410374 no 1119 0.353611495454258 1650 711535
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.374262685686029 0.338008449561072 no 1120 0.354104445292945 1724 676296 Flavone; oxidizing agent.
SGTC_618 k072-0232 33.2 µM 0.37265535241057 0.338672952672442 no 1121 0.354702485082094 1688 5872756 YGL099W LSG1
SGTC_2616 abietic acid 100 µM 0.372316042655186 0.338813294287443 no 1122 0.354828777764326 1804 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2023 5144124 124 µM 0.371596268966078 0.33911107332799 no 1123 0.355096733713753 1638 2830192
SGTC_3081 9117243 49.47 µM 0.371302109375462 0.33923279964185 no 1124 0.355206263513814 1783 45595589
SGTC_357 1325-0123 420 µM 0.37109841277528 0.339317101258837 no 1125 0.355282116591518 1775 1098503
SGTC_1223 0764-0573 147 µM 0.370289611706222 0.339651909979898 no 1126 0.35558335662712 1650 1609797
SGTC_961 1252-1571 372 µM 0.369425502785125 0.340009753611062 no 1127 0.35590529590848 1791 6813498
SGTC_538 2922-0838 53.3 µM 0.367527176768828 0.340796391785517 no 1128 0.356612911971896 1803 777039
SGTC_832 4083-0019 164 µM 0.366166453448552 0.341360681884688 no 1129 0.357120436376496 1804 1990758
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.365611942893542 0.341590738498167 no 1130 0.357327331050974 1814 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2389 9091542 195.52 µM 0.365461053157469 0.341653350169597 no 1131 0.357383637121034 1653 3626624 YOL127W RPL25
SGTC_1944 st076371 56.9 µM 0.363696319981738 0.342385948972517 no 1132 0.358042395834899 1631 24208455
SGTC_299 1273-0059 1.44 µM 0.362031608117634 0.343077569705629 no 1133 0.358664205207702 1709 2848077
SGTC_2119 5528445 120.635 µM 0.360266942220286 0.343811291712353 no 1134 0.359323759051806 1774 791935
SGTC_1426 4048-4480 71.7 µM 0.36011947014872 0.34387263511084 no 1135 0.359378896587106 1757 14224343
SGTC_511 blebbistatin 171 µM 0.359380485824609 0.344180089492512 no 1136 0.35965523552056 1784 3476986 A myosin inhibitor.
SGTC_400 oxethazaine 37.5 µM 0.358183999831943 0.344678105787208 no 1137 0.36010281013782 1681 4621 A local anesthetic.
SGTC_1324 1418-0026 34.4 µM 0.357839422703747 0.344821579952798 no 1138 0.360231743180374 1725 1372513
SGTC_586 0957-0265 8.15 µM 0.356551896340867 0.345357874326566 no 1139 0.360713647286975 1763 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1760 st045453 10.4495 µM 0.355506437498983 0.345793568706336 no 1140 0.361105111536404 1799 3323419 YIL048W NEO1
SGTC_3136 9095672 49.47 µM 0.35548058749857 0.345804344269839 no 1141 0.361114792720958 1825 17217380
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.35439604549792 0.346256547673082 no 1142 0.361521048873131 1780 6710655
SGTC_2947 9072639 7.68 µM 0.353965926993068 0.346435947778456 no 1143 0.361682209272425 1628 16488146
SGTC_3083 9117465 49.47 µM 0.352642169652887 0.346988295855798 no 1144 0.362178359604421 1646 16420915
SGTC_744 1594-0068 283 µM 0.34915424187451 0.34844521600122 no 1145 0.363486758335685 1695 668392
SGTC_321 4534-3890 65.3 µM 0.348531373068901 0.348705626774348 no 1146 0.363720578364578 1811 699746
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.347962578057257 0.348943492509173 no 1147 0.363934143866341 1677 5282362
SGTC_2030 5175110 200 µM 0.346962508847185 0.349361857746068 no 1148 0.364309742386453 1763 2831986
SGTC_2050 5263056 171 µM 0.342374453306508 0.351283547719601 no 1149 0.36603455569519 1840 763468 YGL055W OLE1
SGTC_936 3005-4620 401 µM 0.340772123477122 0.351955577422623 no 1150 0.36663756896878 1828 777207
SGTC_281 1672-3440 14.9 µM 0.339117654605153 0.352649960231051 no 1151 0.367260549591517 1785 6833000
SGTC_1493 4348-0038 111 µM 0.337758424445261 0.353220798660719 no 1152 0.367772621471046 1769 800424
SGTC_1794 st048918 76.9 µM 0.336272433514731 0.353845251112913 no 1153 0.368332717812663 1846 672303
SGTC_950 1165-0508 94.1 µM 0.335952827001504 0.353979609633643 no 1154 0.368453219795263 1670 6148369
SGTC_1661 st013063 9.66 µM 0.335188323278052 0.354301071039904 no 1155 0.36874151487428 1717 721395
SGTC_2827 7993847 71.43 µM 0.33448748009784 0.354595855459387 no 1156 0.369005868418989 1742 2985692
SGTC_2391 6285546 200 µM 0.334249191289706 0.354696102908579 no 1157 0.36909576355093 1682 846083
SGTC_2201 6605497 169.863 µM 0.334171284030178 0.354728880462719 no 1158 0.369125155840016 1801 670741
SGTC_3124 9127567 49.47 µM 0.333663539478763 0.354942527771702 no 1159 0.369316732780876 1833 17592030
SGTC_2328 6201408 200 µM 0.333283318200009 0.355102546078046 no 1160 0.369460215211542 1697 2890418
SGTC_845 0330-0138 4.51 µM 0.33318427551505 0.35514423295714 no 1161 0.36949759349962 1830 9039800
SGTC_3047 9092122 49.47 µM 0.332526755711726 0.355421025740827 no 1162 0.369745769937522 1690 17173831
SGTC_3244 9134489 49.47 µM 0.327658714100226 0.357472664809925 no 1163 0.371584861444005 1704 16584271
SGTC_1994 st072947 40.9 µM 0.326845848138508 0.357815651265759 no 1164 0.371892240175913 1793 5286565 YDL195W SEC31
SGTC_2370 9071495 200 µM 0.326758214347819 0.35785263495368 no 1165 0.371925383070246 1699 21791103
SGTC_2174 5790901 200 µM 0.325245807282379 0.358491119155382 no 1166 0.372497521212563 1739 786020
SGTC_2995 9067767 71.4286 µM 0.323741501041975 0.359126576124322 no 1167 0.373066874092602 1759 11673567
SGTC_3319 9138450 16.7555 µM 0.323046080155381 0.359420471392938 no 1168 0.373330172213921 1743 2029690
SGTC_1140 3229-1848 2.98 µM 0.322942759184806 0.359464143482179 no 1169 0.373369296332915 1849 2849525
SGTC_2289 7946404 165.07 µM 0.322264040300267 0.359751072499599 no 1170 0.373626336406409 1691 1246120 YPR165W RHO1
SGTC_1055 3448-0672 86 µM 0.321772672975153 0.359958847828341 no 1171 0.373812458990557 1750 748378
SGTC_3119 9125183 49.47 µM 0.320066418169695 0.360680660964265 no 1172 0.374458991030418 1852 22695334
SGTC_956 1185-0240 191 µM 0.319979191112942 0.360717574817415 no 1173 0.37449205250635 1763 1416193
SGTC_2852 9023854 51.95 µM 0.319517899112445 0.360912811793542 no 1174 0.374666910318555 1809 19798528
SGTC_1759 st043059 70 µM 0.318360903432451 0.361402657392137 no 1175 0.375105595592111 1671 669426
SGTC_779 1360-0071 233 µM 0.31777514731257 0.361650739897192 no 1176 0.375327751926909 1910 7566
SGTC_2406 ethylparaben 405.7 µM 0.317165714184765 0.3619089119516 no 1177 0.375558931999554 1518 8434 A possible steroid mimic.
SGTC_551 k048-0028 34.9 µM 0.317053008884392 0.361956663799532 no 1178 0.375601690103504 1843 6836383
SGTC_1841 st054148 70 µM 0.316993487951162 0.361981882953208 no 1179 0.375624271754333 1710 675442
SGTC_2584 androsterone 48.74 µM 0.316876743108294 0.362031349746835 no 1180 0.375668564825409 1792 2754130 A steroid.
SGTC_1917 st066507 28.5 µM 0.316736937109606 0.3620905909805 no 1181 0.375721609470387 1722 3156428
SGTC_86 0417-1630 471.922 µM 0.316150957119256 0.362338929399712 no 1182 0.37594396525022 1805 3634867
SGTC_2205 7238770 200 µM 0.315919218490921 0.362437156264316 no 1183 0.376031912087578 1858 279867
SGTC_1296 1068-0102 11.9 µM 0.314727776405204 0.36294231470787 no 1184 0.37648417634471 1830 767053
SGTC_3236 9132701 49.47 µM 0.31377049064551 0.363348366327904 no 1185 0.376847679188309 1728 24282524
SGTC_2011 4012611 177 µM 0.311666747634835 0.36424124951666 no 1186 0.377646900790092 1702 2049887
SGTC_3155 9099265 49.47 µM 0.309782858154688 0.365041447139504 no 1187 0.378363044008525 1803 25236499
SGTC_338 4055-0136 114 µM 0.309274245739552 0.365257585428567 no 1188 0.378556460095219 1719 2900563
SGTC_3341 9147222 25.867 µM 0.308697633004819 0.365502672684874 no 1189 0.378775772269852 1789 1939759
SGTC_2743 auranofin 4.32 µM 0.307698329738345 0.365927553124116 no 1190 0.379155945392125 1826 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.307594603697046 0.3659716644488 no 1191 0.379195413442658 1706 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2497 7-hydroxyflavone 100 µM 0.307063532392831 0.366197539614093 no 1192 0.37939750728857 1859 5281894
SGTC_333 3486-0131 40.1 µM 0.306054707756394 0.366626740404762 no 1193 0.379781496089227 1894 6744690
SGTC_1625 st003711 30.1 µM 0.305330109786234 0.366935120971028 no 1194 0.380057372919699 1846 24207034 YER133W GLC7
SGTC_2941 9056145 11.23 µM 0.305227117249959 0.366978960386407 no 1195 0.380096590317614 1851 2119517
SGTC_2651 TUB2.036 5 µM 0.305026703181268 0.36706427285623 no 1196 0.380172907325339 1861 15992207 YFL037W TUB2
SGTC_3320 9137005 35.139 µM 0.304224531685474 0.367405807739446 no 1197 0.380478418232074 1757 4908713
SGTC_713 1488-1073 324 µM 0.303747483043105 0.36760896713298 no 1198 0.380660139891597 1894 3312542
SGTC_142 0335-0849 62.6745 µM 0.302833388523622 0.367998353534112 no 1199 0.381008418538919 1792 3889043 YPR107C YTH1
SGTC_1953 st076800 12.1 µM 0.297270203315584 0.370371073893892 no 1200 0.38313011413103 1707 297591
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.296786183145311 0.370577745303797 no 1201 0.383314877360388 1915 1273210
SGTC_167 3672-0051 66.205 µM 0.296036036105435 0.370898123818256 no 1202 0.383601280647664 1737 3237971
SGTC_61 0978-8327 98.565 µM 0.29572569334237 0.371030693561634 no 1203 0.383719786944147 1892 6150059 YHR072W ERG7
SGTC_2122 5258151 111.688 µM 0.294868212821305 0.371397064778233 no 1204 0.384047277676463 1763 2173356
SGTC_2002 4023503 131 µM 0.294404515112361 0.371595235049256 no 1205 0.384224408577956 1974 4736863 YCR052W RSC6
SGTC_1975 st070967 30.8 µM 0.294230124733771 0.371669772992892 no 1206 0.384291031351524 1917 261391
SGTC_1476 4112-3294 3.34 µM 0.293506900767562 0.371978944737765 no 1207 0.38456736279935 1872 704369
SGTC_25 0118-0223 35.662 µM 0.293163171135497 0.372125915023657 no 1208 0.384698716558582 1868 5333628
SGTC_3090 9117696 49.47 µM 0.292113513649033 0.372574837825811 no 1209 0.385099917343162 1908 7923821
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.291236631892378 0.372949999819626 no 1210 0.385435174013862 1807 3256 An antibiotic and ribosome inhibitor.
SGTC_157 1348-1695 65.819 µM 0.291214209484372 0.372959594525251 no 1211 0.385443747857748 1776 5380510
SGTC_587 k089-0003 57 µM 0.290627668088707 0.373210607676914 no 1212 0.385668048477329 1906 9659696
SGTC_1652 st011932 78 µM 0.290484317625577 0.373271963370938 no 1213 0.38572287326912 1881 1551076
SGTC_1665 st014639 11.4 µM 0.290292832209208 0.37335392640733 no 1214 0.385796110971937 1851 981133 YIL048W NEO1
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.288013521520483 0.37432999713217 no 1215 0.386668194174648 1812 368090
SGTC_1527 coumarin 137 µM 0.284684954642262 0.375756838109829 no 1216 0.387942759175241 1867 323 A hepatotoxic, DNA x-linker.
SGTC_639 0833-0042 114 µM 0.284319353060833 0.375913662811812 no 1217 0.388082828137521 1764 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2480 5767542 37.17 µM 0.284191789993322 0.375968385780765 no 1218 0.388131703417201 1850 2867358
SGTC_403 arphamenine a 50 µM 0.283865253555334 0.376108477212379 no 1219 0.388256822620141 1835 5487158 An arginine aminopeptidase inhibitor.
SGTC_1475 4092-1048 11.7 µM 0.283747900970449 0.376158828083842 no 1220 0.388301791528644 1809 2881759
SGTC_130 0136-0219 337.655 µM 0.28280115360682 0.376565113083155 no 1221 0.388664634982867 1943 234244
SGTC_2028 5153890 36.43 µM 0.281745217994135 0.377018416209442 no 1222 0.389069439727121 1796 2830968 YPR165W RHO1
SGTC_1916 st067606 49.2 µM 0.278638973200348 0.378352878478409 no 1223 0.390260950222339 1902 19590279
SGTC_3170 9103054 49.47 µM 0.277921173556502 0.378661456858815 no 1224 0.390536434905327 1798 16432970
SGTC_3151 9099821 49.47 µM 0.277479892307663 0.378851199820185 no 1225 0.390705821744938 1773 17174189
SGTC_1267 0828-0272 9.49 µM 0.276840480578172 0.379126187107952 no 1226 0.390951298227249 1926 745334
SGTC_431 k089-0097 107 µM 0.276376515970127 0.379325759401565 no 1227 0.391129446037684 1820 5499420
SGTC_265 mycophenolic acid 32.932 µM 0.276320459295525 0.379349874107245 no 1228 0.391150971584393 1923 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1406 3909-7906 11.9 µM 0.276073008523924 0.379456329171848 no 1229 0.391245995709336 1860 X1406
SGTC_3284 9108171 64.8615 µM 0.275972784897147 0.379499448682843 no 1230 0.391284484656125 1833 8687505
SGTC_3291 9121177 71.43 µM 0.274969263193926 0.379931279381843 no 1231 0.39166992640685 1786 17015612
SGTC_2402 5553605 200 µM 0.272906775516628 0.380819268932744 no 1232 0.392462439024679 1869 6758546
SGTC_353 1988-1175 58.3 µM 0.272842596159884 0.380846911004081 no 1233 0.392487107170846 1765 2788357
SGTC_2372 9071633 200 µM 0.27269096047342 0.380912222962829 no 1234 0.392545391977469 1951 21321366
SGTC_1144 3486-0183 12.5 µM 0.272427834648803 0.381025563590767 no 1235 0.392646536406915 1841 6744069
SGTC_492 tmb-8 126 µM 0.270891053805926 0.381687730766676 no 1236 0.393237412946445 1945 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2606 farnesol 9.78 µM 0.270792714937272 0.381730114768864 no 1237 0.393275231626456 1920 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1581 himbacine 57.9 µM 0.269998831165519 0.38207233015637 no 1238 0.393580576409013 1798 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_3033 9090887 49.47 µM 0.268912972690483 0.382540554758373 no 1239 0.393998326904704 1781 19325384
SGTC_801 0866-0028 10.1 µM 0.268282724972939 0.38281239780667 no 1240 0.394240851224652 1832 6849771
SGTC_2204 7233102 200 µM 0.268267617246249 0.382818914890824 no 1241 0.394246665301369 1891 2172480
SGTC_2382 9035899 200 µM 0.266285043006309 0.383674433545891 no 1242 0.395009845669605 1806 6462679
SGTC_260 nsc-65238 3.989 µM 0.265041210411471 0.384211460985113 no 1243 0.395488857671197 1900 3246252
SGTC_1996 st072960 66.8 µM 0.265031295498044 0.38421574266529 no 1244 0.395492676635991 1964 1719405
SGTC_1388 3346-4487 254 µM 0.264403367186012 0.384486937507424 no 1245 0.395734558592927 1890 3345614
SGTC_1519 esterone 74 µM 0.264083695487148 0.384625021678151 no 1246 0.395857713586077 1735 698 A steroid.
SGTC_3334 9142812 21.919 µM 0.263379960319732 0.38492905600538 no 1247 0.396128867419764 1903 45283678
SGTC_1826 st055655 41.6 µM 0.263225396245086 0.384995841724282 no 1248 0.396188428720619 1842 676168
SGTC_3055 9094636 49.47 µM 0.262129901725787 0.385469292538716 no 1249 0.396610647157351 1885 25236176
SGTC_2303 7774051 200 µM 0.261078053611207 0.385924040923099 no 1250 0.397016157795714 1925 2953184
SGTC_2241 6772625 37.8075 µM 0.260625344982041 0.386119809991307 no 1251 0.397190721260424 1917 2285411
SGTC_1044 1222-0021 1.78 µM 0.260039790281785 0.386373069948008 no 1252 0.397416540427687 1889 4306703
SGTC_452 diindolylmethane 8 µM 0.259792302168605 0.386480126309548 no 1253 0.397511994559997 1902 3071 Inhibits expression of several cancer promoting factors.
SGTC_2216 7189485 200 µM 0.259646209949899 0.386543325729995 no 1254 0.397568344009843 1934 731273
SGTC_2546 rhodinyl acetate 100 µM 0.25945291111802 0.386626951332639 no 1255 0.397642904878541 1976 6708682
SGTC_1411 3909-8223 150 µM 0.25896908834373 0.386836287471558 no 1256 0.397829545499984 1952 X1411
SGTC_1932 st074806 40.9 µM 0.258458092515328 0.387057416357982 no 1257 0.398026693856146 1902 17251235
SGTC_1085 doxorubicin 7.67 µM 0.257563927127973 0.387444446617618 no 1258 0.398371736270699 1949 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_179 1273-0063 6.77 µM 0.256238883831686 0.388018183591443 no 1259 0.398883192826418 1797 3108139
SGTC_100 0086-0128 49.5915 µM 0.253187614687291 0.389340295481435 no 1260 0.400061618415866 1762 93297
SGTC_763 3453-1109 128 µM 0.251626094948504 0.390017397350204 no 1261 0.400665043308031 1977 1560353
SGTC_2981 9013952 38.96 µM 0.250949542555485 0.390310865905367 no 1262 0.400926560116037 1734 2996344
SGTC_1235 benzylparaben 21.5 µM 0.250021628920928 0.390713469221904 no 1263 0.401285311125564 1878 7180
SGTC_2411 st077133 39.94 µM 0.249495310397597 0.390941880499964 no 1264 0.401488833998547 2008 1403142 YNL221C POP1
SGTC_425 3825-7017 13.1 µM 0.249489994085212 0.390944187860906 no 1265 0.401490889907529 1907 3397440
SGTC_266 formosanin C 406 nM 0.24904190528487 0.391138679048887 no 1266 0.401664183310681 1952 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_3249 9135183 49.47 µM 0.248839852344461 0.391226388245314 no 1267 0.40174233138603 1908 4902779
SGTC_847 0342-0274 5.54 µM 0.247922857844733 0.391624516008381 no 1268 0.40209704695681 1971 18097
SGTC_427 1354-0053 47.3 µM 0.247523531564051 0.391797925383271 no 1269 0.402251541209889 1955 6813657
SGTC_1778 st046819 58.9 µM 0.247097519224612 0.391982947010311 no 1270 0.402416376795024 1837 671715
SGTC_2763 lisinopril 49.32 µM 0.246291929327216 0.3923328898953 no 1271 0.402728128514081 1995 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_775 4577-0580 57.3 µM 0.245752653827352 0.392567196258255 no 1272 0.402936854964131 1927 2006902
SGTC_1013 4112-3890 241 µM 0.2454764359609 0.392687223480004 no 1273 0.403043775738847 1842 705171
SGTC_2552 juarezic acid 87.02 µM 0.245106934900824 0.39284780177207 no 1274 0.403186816704926 2002 1549512
SGTC_2179 6298986 200 µM 0.244977993625982 0.392903841547237 no 1275 0.403236735402249 2001 738374
SGTC_1335 1486-0900 202 µM 0.24485629356562 0.392956736220406 no 1276 0.403283852161411 1867 X1335
SGTC_694 1315-0438 43.2 µM 0.243706175064444 0.393456711362796 no 1277 0.403729195269638 1921 6793154
SGTC_23 0213-0011 39.996 µM 0.243610160025058 0.39349845861484 no 1278 0.403766379384662 1972 627608
SGTC_659 k018-0002 107 µM 0.242990850344216 0.393767763301026 no 1279 0.404006242719645 2000 6797879 YHR007C ERG11
SGTC_1277 0873-0036 22 µM 0.242861904488733 0.39382384135896 no 1280 0.404056188970536 1942 5965735
SGTC_339 3091-4833 71.4 µM 0.240095971320775 0.395027263444504 no 1281 0.405127928652167 1916 3240077
SGTC_1885 st057546 99.9 µM 0.239808830104885 0.395152252517231 no 1282 0.405239230629334 1962 702008
SGTC_3266 9136860 49.47 µM 0.239544159405562 0.395267470003482 no 1283 0.405341829349863 1877 4871271 YPR165W RHO1
SGTC_2088 5278280 127.392 µM 0.239071252933963 0.395473360293021 no 1284 0.405525166169095 1901 791502
SGTC_3173 9105693 49.47 µM 0.238553964728928 0.395698606564047 no 1285 0.40572573267679 1934 17096658
SGTC_3060 1327-0027 12.5 µM 0.238424710065915 0.395754894231703 no 1286 0.40577585204249 1998 16000455 YPR107C YTH1
SGTC_2034 5197015 53.07 µM 0.238318457677847 0.395801166524144 no 1287 0.405817053277993 1988 780676
SGTC_3283 9109332 35.8195 µM 0.237947210478218 0.395962854029992 no 1288 0.405961019108755 1884 17027281
SGTC_969 1313-0238 134 µM 0.237629060710113 0.396101430512367 no 1289 0.406084404424218 1863 5212874
SGTC_728 3030-5151 22.5 µM 0.237618504935614 0.396106028515809 no 1290 0.40608849834031 1886 3125388
SGTC_1359 1582-0056 520 nM 0.236431014501564 0.396623381135328 no 1291 0.406549116090303 1934 3661189
SGTC_2837 9008476 45.46 µM 0.236024731942832 0.396800427642035 no 1292 0.406706739472602 1917 2992805
SGTC_1805 st050013 60.3 µM 0.234663182683343 0.397393907418455 no 1293 0.407235082896582 1955 4037144
SGTC_1160 4092-0570 10.5 µM 0.232871353377927 0.398175302022218 no 1294 0.407930651821605 1823 4994975
SGTC_778 3456-2434 196 µM 0.231118967541101 0.398939891013178 no 1295 0.408611190012437 2026 5539063
SGTC_3264 9137442 49.47 µM 0.230872719048555 0.399047363623969 no 1296 0.40870684263205 2010 17015726
SGTC_3186 9110464 49.47 µM 0.230622067877971 0.399156765597867 no 1297 0.408804211010212 1979 17018021
SGTC_3106 9121286 49.47 µM 0.230310424193861 0.399292800082906 no 1298 0.408925280492523 1995 15943471
SGTC_2582 agaric acid 100 µM 0.23027773603009 0.399307069386868 no 1299 0.408937979919001 1846 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_920 mycophenolic acid 780.421 nM 0.230183305680225 0.399348291649271 no 1300 0.408974666863072 1850 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2663 amphotericin b 100 µM 0.229961619900731 0.399445069917405 no 1301 0.40906079668948 1915 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2306 7482397 179.52 µM 0.229733368550399 0.3995447208817 no 1302 0.409149481973207 1979 891448
SGTC_859 0439-0102 54.6 µM 0.228879700625739 0.399917476886424 no 1303 0.409481209180303 2032 610143
SGTC_2320 7373003 200 µM 0.227427970015405 0.400551587589077 no 1304 0.410045486563833 1829 5415828
SGTC_109 0132-0036 33.701 µM 0.226276473485676 0.401054743677696 no 1305 0.410493197662206 2028 67274 A color developer.
SGTC_917 harmaline 728.087 nM 0.226092359835381 0.401135208928624 no 1306 0.410564793361173 1937 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2390 9097792 176.6 µM 0.224505451355467 0.401828926821649 no 1307 0.411182012802369 1831 4497149
SGTC_2741 miltefosine 3.04 µM 0.223883791760664 0.402100770121441 no 1308 0.411423863964644 1926 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1677 st019204 53.9 µM 0.223799320200508 0.402137712045711 no 1309 0.411456729477185 1831 3945625
SGTC_3278 9139605 49.47 µM 0.222173890805131 0.402848730516797 no 1310 0.412089259162139 1977 7958859
SGTC_3257 9139206 32.98 µM 0.222037903621899 0.402908230568805 no 1311 0.412142188437308 1997 4910041
SGTC_1331 1472-0049 76.2 µM 0.221712472519173 0.403050629346076 no 1312 0.41226886004056 1866 24051409
SGTC_2581 avocatin a 64 µM 0.220847706951032 0.403429086958371 no 1313 0.412605507897393 1904 6710728 A skin care supplement.
SGTC_3180 9109287 49.47 µM 0.220352000448221 0.403646069685169 no 1314 0.412798512364199 1928 18891271
SGTC_8 0354-0001 70 µM 0.219974269245981 0.403811431684137 no 1315 0.412945597032477 1919 4993152
SGTC_695 3505-6186 243 µM 0.21946979224307 0.404032306878767 no 1316 0.413142054277712 1950 1819379
SGTC_1179 1021-1431 9.29 µM 0.218766301946934 0.404340367149071 no 1317 0.413416049089369 1936 2840958
SGTC_1294 1000-1494 117 µM 0.216457653392922 0.405351746286626 no 1318 0.414315515184425 1866 712797 YDL207W GLE1
SGTC_1539 benzyladenosine 56 µM 0.21557721221658 0.405737619316993 no 1319 0.414658660078257 1921 92208 A nucleotide analog.
SGTC_1442 4112-3290 3 µM 0.214994704949517 0.405992966530583 no 1320 0.41488572343709 1971 704353
SGTC_278 4092-0821 23.9 µM 0.214357486262978 0.406272342784555 no 1321 0.415134146065177 1983 877900
SGTC_967 1306-0166 352 µM 0.21421348533922 0.406335483831075 no 1322 0.415190290190208 2042 4437607
SGTC_990 3985-0011 41.3 µM 0.214181780106068 0.406349386163591 no 1323 0.41520265188924 1938 5399565 YGL099W LSG1
SGTC_1169 aniline yellow 25.8 µM 0.212950361366573 0.406889438447582 no 1324 0.415682840230041 1975 6051 A DNA damaging agent.
SGTC_1437 4092-1038 11.6 µM 0.211338726295758 0.407596506227429 no 1325 0.416311483039101 1945 3977136
SGTC_2266 7929956 200 µM 0.210848251178706 0.407811750764669 no 1326 0.416502842905899 1996 2967153
SGTC_148 3253-0744 288.01 µM 0.210632201802562 0.407906572660172 no 1327 0.416587141291841 2034 6893655
SGTC_1648 st011736 69.8 µM 0.209674229652493 0.408327081904769 no 1328 0.416960970096044 2015 2855514
SGTC_2957 9076800 11.52 µM 0.209164824748648 0.408550732138748 no 1329 0.417159785420587 1893 16459615
SGTC_226 1,3-diallylurea 8.28947 mM 0.208530393725236 0.408829315754024 no 1330 0.417407426728442 1972 74537 YKL182W FAS1
SGTC_1234 0326-0494 15.5 µM 0.207937079359332 0.409089886412556 no 1331 0.41763904837226 2025 1547813
SGTC_684 1140-0066 328 µM 0.206599866442103 0.409677308155778 no 1332 0.418161182288743 1920 6813534
SGTC_3027 9089541 49.47 µM 0.206243310772361 0.409833973127059 no 1333 0.418300428951075 1931 9943819
SGTC_454 lyso-paf C-16 6.67 µM 0.206008358235152 0.409937215458462 no 1334 0.418392191207148 1851 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2337 9009472 200 µM 0.204084479388681 0.410782836376294 no 1335 0.419143741373374 2047 5742383
SGTC_449 xestospongin c 11.1929 µM 0.201876105663526 0.411754015249547 no 1336 0.420006791199218 2004 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1753 st043925 64 µM 0.201700152558004 0.41183141767521 no 1337 0.420075571663462 2060 670181
SGTC_1876 myriocin 605 nM 0.200512253987721 0.412354068294805 no 1338 0.420539987651071 2067 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_370 0180-0345 38.7 µM 0.199872486538958 0.412635617113986 no 1339 0.420790154403914 1921 3989527
SGTC_2906 7926292 26.41 µM 0.199267096912285 0.412902078343346 no 1340 0.421026907938845 1945 2966319
SGTC_1714 st033236 13.627 µM 0.19922737987652 0.412919561134304 no 1341 0.421042441329518 2008 2916566
SGTC_305 1682-2595 20.8 µM 0.198655515232401 0.413171305748009 no 1342 0.421266112040751 1977 226033
SGTC_60 0986-0278 202 µM 0.197883474583078 0.413511227892658 no 1343 0.421568116942993 1773 3110598
SGTC_567 1080-0542 68.4 µM 0.195965542911101 0.414355954998861 no 1344 0.422318567912563 2059 5950415
SGTC_1136 pergolide 1.05886 µM 0.195538790805811 0.414543966238271 no 1345 0.422485586531869 1918 47811 A dopamine receptor agonist.
SGTC_2798 7813637 45.45 µM 0.194093400010842 0.415180897336896 no 1346 0.423051374694889 1981 956368
SGTC_2874 9043904 71.43 µM 0.194013676569019 0.415216035058945 no 1347 0.423082586511074 1933 4463428
SGTC_501 nsc-95397 161 µM 0.193760151366961 0.415327779573494 no 1348 0.423181845117557 2042 262093
SGTC_2617 dihydrotanshinone i 20.83 µM 0.193671633383164 0.415366796634256 no 1349 0.423216502275443 1938 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_902 1120-0002 2.07 µM 0.192974030309275 0.415674316111199 no 1350 0.42348965330597 2001 3280475
SGTC_287 k060-0039 29.6 µM 0.192806677311926 0.4157480968495 no 1351 0.423555186936857 2067 5861974
SGTC_2340 7987427 183.45 µM 0.192058752621128 0.416077869875829 no 1352 0.423848092006349 1986 2239331
SGTC_470 aa-861 153 µM 0.191454707824584 0.416344246897689 no 1353 0.424084681014277 1929 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_40 0327-0103 19.753 µM 0.191348069274309 0.416391277303873 no 1354 0.424126451470545 1933 409036
SGTC_539 4859-0462 2.54 µM 0.190779829398864 0.416641906206124 no 1355 0.42434904611577 2094 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1764 st044502 93.5 µM 0.190290547389406 0.416857736966851 no 1356 0.42454073020683 1963 8407
SGTC_3333 9141820 12.094 µM 0.190248431379729 0.416876316239896 no 1357 0.424557230665409 1936 1939433
SGTC_190 3970-0790 3.722 µM 0.190113170327655 0.41693598725126 no 1358 0.424610224931876 2066 2832352
SGTC_162 k030-0015 37.8 µM 0.189867572572964 0.417044338677916 no 1359 0.424706451774475 2056 1809920 YMR134W ERG29
SGTC_3076 9116187 49.47 µM 0.189079260005826 0.417392164483777 no 1360 0.425015348198725 2076 27241210
SGTC_2583 asiatic acid 100 µM 0.188853314056013 0.41749187016153 no 1361 0.425103892512426 1997 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1208 2323-2347 50.3 µM 0.188372638347065 0.417704000908315 no 1362 0.42529227358086 2110 5412760
SGTC_3129 9127257 49.47 µM 0.188275153671832 0.417747025553903 no 1363 0.425330480770564 1822 837894
SGTC_2560 caryophyllene 100 µM 0.188132474129413 0.417809998629012 no 1364 0.425386402458463 2053 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_3128 9127691 49.47 µM 0.188045023916847 0.417848596716449 no 1365 0.425420678355947 1997 41316314
SGTC_2009 4012297 12.05 µM 0.187987140619684 0.417874145226452 no 1366 0.425443365883096 1931 45595307
SGTC_1886 st057356 49.9 µM 0.187388060105865 0.418138587518093 no 1367 0.425678191724153 1885 24207747
SGTC_345 1362-0200 395 µM 0.187307929658026 0.418173960997137 no 1368 0.425709603025247 1910 1419823
SGTC_998 3996-0085 177 µM 0.185835852534947 0.41882392495854 no 1369 0.426286743985778 2056 715391
SGTC_485 niflumic acid 177 µM 0.185637022777331 0.418911730986755 no 1370 0.42636470909604 2041 4488 A COX2 inhibitor.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.185050735171831 0.419170667371884 no 1371 0.426594620892053 2001 6708739 YPR165W RHO1
SGTC_2646 retinol 96.75 µM 0.184893586020928 0.419240078909725 no 1372 0.426656250935863 2018 445354 A vitamin A analog and teratogen.
SGTC_1618 st003135 44.5 µM 0.184674154372326 0.419337004339186 no 1373 0.426742309643788 2071 1270615
SGTC_1036 k216-0215 33.5 µM 0.1845776809948 0.419379619265536 no 1374 0.426780146557957 1922 622330
SGTC_2182 6325192 200 µM 0.184326190831338 0.419490713785589 no 1375 0.426878784311393 2114 736248
SGTC_125 0133-0007 11.75 µM 0.183764139219406 0.419739020456012 no 1376 0.427099244874011 2103 26541
SGTC_2884 9058502 51.95 µM 0.183118724055466 0.420024195411435 no 1377 0.427352432253593 1979 6471554
SGTC_1368 1852-0141 284 µM 0.182862343478277 0.420137488143056 no 1378 0.427453015093597 1986 2838987
SGTC_3231 9132313 49.47 µM 0.180966414557365 0.420975490296539 no 1379 0.428196969011397 1994 4905967
SGTC_1817 st052116 64.4 µM 0.179824032489473 0.421480597291645 no 1380 0.428645357980554 2066 4361398
SGTC_375 3970-0961 9.27 µM 0.179221627089429 0.421747004391846 no 1381 0.428881841346127 2018 2898222
SGTC_1804 st050076 49.1 µM 0.177162790195614 0.42265777182843 no 1382 0.429690261205786 2039 3895976
SGTC_3181 9108277 49.47 µM 0.17669328386543 0.422865525379658 no 1383 0.429874658285468 1982 17097298
SGTC_3330 9141424 71.43 µM 0.17626027293031 0.423057148971072 no 1384 0.430044735479167 2093 27261020
SGTC_1807 st050092 58.9 µM 0.17603720469932 0.423155872143519 no 1385 0.430132356853632 2003 5008496
SGTC_1862 st057513 3.81 µM 0.175157098594169 0.423545427189181 no 1386 0.430478096743834 1999 5393163
SGTC_78 0336-0123 156.75 µM 0.174974645995957 0.423626194238227 no 1387 0.430549777895772 1892 6765896
SGTC_2835 9006588 71.43 µM 0.174028512402699 0.424045074513467 no 1388 0.430921527235132 1940 2345538
SGTC_783 0848-0141 92.7 µM 0.173778312516801 0.424155859493458 no 1389 0.431019844574881 2030 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_451 chloral hydrate 100 µM 0.173588313158486 0.424239992533302 no 1390 0.431094508661891 1998 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_608 k048-0125 159 µM 0.172666097202383 0.424648405164642 no 1391 0.431456946993337 2095 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1247 0448-0043 5.84 µM 0.171549762155308 0.4251428936011 no 1392 0.431895752889776 1977 3089013 YGL099W LSG1
SGTC_21 0849-0113 22.993 µM 0.170968360428762 0.425400476271996 no 1393 0.432124321991198 2001 1560156
SGTC_324 1315-0088 19.6 µM 0.170193093241928 0.425743998104104 no 1394 0.432429141637297 2057 6787421
SGTC_2771 fluoxetine 41.05 µM 0.16854822758462 0.426473026427709 no 1395 0.433076003093889 2075 3386 A selective serotonin reuptake inhibitor.
SGTC_992 3909-8734 162 µM 0.168318891040922 0.426574691728738 no 1396 0.433166206490299 1974 4288319
SGTC_825 1988-2224 89.6 µM 0.168173272846461 0.426639247068211 no 1397 0.433223483320577 2004 1180859
SGTC_2664 lyso-paf C-16 73.48 µM 0.167827316445962 0.426792624055802 no 1398 0.433359565936245 2073 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_723 4182-0001 115 µM 0.167603834117985 0.426891709035006 no 1399 0.433447477341523 1959 744821 YLR208W SEC13
SGTC_2610 ononetin 44.17 µM 0.166971941364157 0.427171895191966 no 1400 0.43369606325607 1979 259632
SGTC_473 2-arachidonoylglycerol 10 µM 0.166878961117564 0.427213126460202 no 1401 0.433732643798874 1948 5282280 An endocannabinoid.
SGTC_985 1493-0307 8.71 µM 0.165866884581812 0.427661974188205 no 1402 0.434130854364909 2133 3278274
SGTC_1546 5-methoxyflavanone 78.7 µM 0.165240529371203 0.427939804583833 no 1403 0.434377332940486 2125 147795
SGTC_652 0437-0092 114 µM 0.164861303443198 0.428108034000625 no 1404 0.434526575470677 2025 3091274
SGTC_747 3448-8087 38.7 µM 0.164840875280509 0.428117096563091 no 1405 0.434534615140364 1992 5168703
SGTC_1389 3405-0187 19 µM 0.16468488649275 0.428186299245937 no 1406 0.434596006689759 1958 799890
SGTC_971 1315-0384 26.7 µM 0.16443735166884 0.428296119837358 no 1407 0.43469343068696 1950 6769120
SGTC_1421 4029-0249 71.4 µM 0.163962683867707 0.42850672512308 no 1408 0.434880260073336 2141 2894095
SGTC_1150 3909-7983 10.9 µM 0.16345121422532 0.428733681801765 no 1409 0.435081590949974 1984 23965914
SGTC_3318 9139014 38.6185 µM 0.16310149473475 0.428888877943952 no 1410 0.435219261464645 1988 16643984
SGTC_726 3448-4391 34.2 µM 0.162952673576236 0.428954924124102 no 1411 0.435277848759247 2076 1356692
SGTC_93 0109-0045 59.227 µM 0.162554551724436 0.429131618637154 no 1412 0.435434586694721 2137 88733
SGTC_1132 3456-3614 2.5 µM 0.161766244789413 0.429481527032107 no 1413 0.43574496781719 2145 3125502
SGTC_1215 3852-0577 11.2 µM 0.161406553075531 0.429641203003509 no 1414 0.435886602869279 2094 2884876
SGTC_81 0411-0046 9.971 µM 0.159585223838653 0.430449911888927 no 1415 0.436603909731956 2056 12925265
SGTC_323 4013-0906 34.3 µM 0.159045392016176 0.430689664903259 no 1416 0.436816555649282 2134 2910086
SGTC_1787 fluconazole 80 µM 0.157395466541602 0.431422596692911 no 1417 0.437466593051453 2044 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1361 1608-0041 5.61 µM 0.156978889788739 0.431607686339443 no 1418 0.437630742663489 2034 X1361
SGTC_1720 st037298 9.481 µM 0.15626084087439 0.431926758620574 no 1419 0.437913710785235 2006 597396
SGTC_2063 5246145 200 µM 0.155903619163032 0.432085510248838 no 1420 0.438054496257657 2072 711240
SGTC_2154 5570129 200 µM 0.15574154773687 0.432157539452043 no 1421 0.438118373187908 2117 673366
SGTC_2466 5983409 37.09 µM 0.155296705713459 0.43235525162373 no 1422 0.438293706284692 2019 2879657
SGTC_866 0495-0101 262 µM 0.153991350301877 0.432935520708553 no 1423 0.438808277847995 1919 635694
SGTC_1048 3161-0300 24.5 µM 0.153341191746337 0.433224589452848 no 1424 0.439064609226046 2103 2165101
SGTC_2284 7945075 39.21 µM 0.152978720005284 0.43338576451131 no 1425 0.439207528362496 2156 1245402
SGTC_2445 5742597 35.57 µM 0.151616529625268 0.433991568815148 no 1426 0.439744697689279 2017 1774255
SGTC_1746 st038117 42 µM 0.151224738532955 0.434165838090459 no 1427 0.439899218089254 2014 2898218
SGTC_2165 5727197 32.143 µM 0.150687135320097 0.434404985637425 no 1428 0.440111260938444 2042 1361712
SGTC_925 2064-1272 59.6 µM 0.150193452878216 0.434624616604109 no 1429 0.440305995575487 1956 6815817
SGTC_2013 4024628 200 µM 0.149557588091888 0.434907531811919 no 1430 0.440556835768498 2077 5230760
SGTC_2912 7964298 10.93 µM 0.148861850042755 0.435217124601342 no 1431 0.440831322493805 2028 2975850
SGTC_932 2857-0803 154 µM 0.148750039987831 0.435266882074617 no 1432 0.440875437118581 2142 674898
SGTC_1697 st025554 27.742 µM 0.148335201144681 0.435451501726093 no 1433 0.441039118070803 2114 1269519
SGTC_2954 9074818 52.69 µM 0.146024279941344 0.436480209232647 no 1434 0.441951110623767 2068 16648742
SGTC_3212 9128307 49.47 µM 0.145430998400716 0.436744378356663 no 1435 0.442185295820125 1835 27243542
SGTC_2920 7982904 15.77 µM 0.14258954885541 0.438009973231039 no 1436 0.443307175970049 2045 6456808
SGTC_1262 0737-0114 49.6 µM 0.142030450710603 0.438259073246151 no 1437 0.443527976654853 2170 765919
SGTC_1325 1431-0015 227 µM 0.142018427747248 0.438264430213983 no 1438 0.443532724991752 1949 1103340
SGTC_212 3807-4682 38.772 µM 0.140534239720971 0.438925813627732 no 1439 0.444118950764821 2128 3125501 YBL034C STU1
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.140330219179045 0.43901674257476 no 1440 0.44419954455036 2176 1241132 A phosphatase inhibitor.
SGTC_293 4049-0273 38.5 µM 0.140161649518603 0.439091874014937 no 1441 0.444266135993242 2098 1380311
SGTC_1480 1070-0044 41.2 µM 0.139625003420043 0.439331071597893 no 1442 0.444478142131128 2160 3124987
SGTC_1455 4262-0120 131 µM 0.139015634979898 0.439602710337662 no 1443 0.444718897042979 2121 1529587
SGTC_1103 duloxetine 36.1 µM 0.138587028189785 0.439793787830986 no 1444 0.444888247195504 2140 60835 A selective serotonin reuptake inhibitor.
SGTC_545 4218-0007 221 µM 0.138507815022517 0.439829103445459 no 1445 0.444919546826585 2085 2840508
SGTC_1692 fluoroquinolonic acid 71 µM 0.137576549917412 0.440244325289961 no 1446 0.445287544861808 2123 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3197 9113331 49.47 µM 0.137573733433183 0.440245581171683 no 1447 0.445288657893322 2122 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2575 plumbagin 510 nM 0.135526304997355 0.441158696064506 no 1448 0.446097883868541 2009 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_383 2324-0395 7.37 µM 0.135484006603633 0.441177563674514 no 1449 0.446114604272289 2105 3146421
SGTC_2483 5729050 27.16 µM 0.134803601286958 0.441481083402283 no 1450 0.446383579207745 2158 2865180
SGTC_1354 1498-1681 81 µM 0.133419529452273 0.442098605247968 no 1451 0.446930800606215 2062 5754243
SGTC_760 0568-0725 82.9 µM 0.132867782773193 0.442344813600087 no 1452 0.447148973287232 2186 3916171
SGTC_1449 4112-4002 201 µM 0.131562415060871 0.442927402094361 no 1453 0.44766520774242 1995 2059539
SGTC_2811 7967822 32.47 µM 0.131474726311922 0.44296654221451 no 1454 0.447699889245772 2125 2232244
SGTC_2938 9059746 27.26 µM 0.13094394512122 0.443203469761305 no 1455 0.447909825383087 2112 6471769
SGTC_1311 1190-0148 100 µM 0.130764285974321 0.443283669748951 no 1456 0.447980888005425 2164 1961333
SGTC_1236 0330-0013 258 µM 0.130287885436558 0.443496346572763 no 1457 0.448169332196459 2048 4617066
SGTC_462 ag-879 158 µM 0.129992215506001 0.443628349033563 no 1458 0.448286292779332 2176 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2812 7970281 58.44 µM 0.129559873033519 0.44382138049413 no 1459 0.44845732613209 2153 2233435
SGTC_2842 9000675 19.48 µM 0.126797472855766 0.445055044522396 no 1460 0.449550347981613 1979 2989072
SGTC_2953 9074162 66.49 µM 0.122998300668658 0.4467525891277 no 1461 0.451054221809862 2202 16451992
SGTC_3282 9108498 15.4605 µM 0.122542206605362 0.446956447136593 no 1462 0.451234810905036 2068 16459645
SGTC_2823 7987624 58.44 µM 0.122131979582187 0.447139816166056 no 1463 0.451397247704417 2106 2239440
SGTC_516 3992-2719 87.3 µM 0.122124678656373 0.447143079738757 no 1464 0.451400138711654 2151 5350887 YDR037W KRS1
SGTC_1087 pterostilbene 9.05 µM 0.122089404401943 0.447158847665297 no 1465 0.451414106582653 2173 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1255 0566-0045 221 µM 0.121648487374006 0.447355948800826 no 1466 0.451588705623735 2100 2788469
SGTC_648 0375-0473 33.3 µM 0.121543589950248 0.4474028425359 no 1467 0.451630245407963 2109 1713139
SGTC_2128 5255449 168.493 µM 0.120813688932413 0.447729160527801 no 1468 0.451919303664218 2151 736008
SGTC_422 cantharidin 155 µM 0.120436163621921 0.44789795525633 no 1469 0.452068822726054 2122 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_464 bw-b 70c 158 µM 0.120272343494863 0.447971203544454 no 1470 0.452133705874264 2188 5353454
SGTC_2756 carbadox 75.1 µM 0.120209664217506 0.447999229567537 no 1471 0.45215853117702 2077 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2661 dactinomycin 12.96 µM 0.119476766038044 0.448326952336878 no 1472 0.452448823094747 2183 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_35 0133-0054 64.071 µM 0.118542837465966 0.448744618938866 no 1473 0.452818777483547 2099 99677
SGTC_1617 st002906 78 µM 0.117960041933779 0.449005282494645 no 1474 0.453049659345485 2110 5150859
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.116458921675471 0.449676780886691 no 1475 0.453644420134893 2223 5024745
SGTC_1985 st071382 65.5 µM 0.116037514052062 0.449865315787777 no 1476 0.453811405341833 2221 6123237
SGTC_3300 9124615 50.48 µM 0.115064677783996 0.450300599257544 no 1477 0.454196928472395 2171 24824903
SGTC_1297 1068-0111 14.1 µM 0.114310123191606 0.450638256511248 no 1478 0.454495978978175 2121 767057
SGTC_3068 9116768 49.47 µM 0.113773645768664 0.450878347690618 no 1479 0.454708615270478 2110 41904888
SGTC_1178 0988-0033 191 µM 0.113757008431668 0.450885793730449 no 1480 0.454715209794284 2142 5392207
SGTC_12 0849-0099 9.267 µM 0.112982212031353 0.45123257294476 no 1481 0.455022328824621 2204 6071388
SGTC_1231 0242-0792 125 µM 0.111400890911275 0.451940447392583 no 1482 0.455649226807332 2104 3707635
SGTC_184 1494-0393 24.714 µM 0.110696992868474 0.452255594878602 no 1483 0.455928315334385 2126 3090647
SGTC_2084 5306078 60.6385 µM 0.109517290808198 0.452783835520314 no 1484 0.456396104087816 2141 679340
SGTC_2477 5967686 25.23 µM 0.109127111977918 0.452958566135382 no 1485 0.456550835526715 2142 776118
SGTC_230 MPP+ 141.667 µM 0.107003773739684 0.453909602239217 no 1486 0.457392992967491 2083 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2369 9071472 200 µM 0.105867794799343 0.454418512302184 no 1487 0.457843623230005 2154 17296037
SGTC_211 3455-0679 143.504 µM 0.105789589257536 0.454453550562388 no 1488 0.457874648502765 2106 748649
SGTC_3031 9088762 49.47 µM 0.105181871785973 0.454725836967246 no 1489 0.458115747571097 2220 205253
SGTC_2344 7990960 76.95 µM 0.105137919985097 0.454745530296255 no 1490 0.458133185118251 2123 140813
SGTC_220 paclitaxel 373.376 µM 0.105084333063634 0.454769540950369 no 1491 0.458154445436197 2203 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2643 anethole 100 µM 0.103874941055083 0.455311476160125 no 1492 0.458634296824987 2173 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_829 1635-0120 117 µM 0.103250780037179 0.455591198747265 no 1493 0.458881969296593 2217 285054
SGTC_2689 tacrolimus 100 µM 0.102887421515378 0.455754050826737 no 1494 0.459026160446869 2112 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_725 1497-0963 19 µM 0.102111578034071 0.456101797599668 no 1495 0.459334055555551 2226 3549977
SGTC_101 0490-5701 117.494 µM 0.101644560518855 0.456311139342445 no 1496 0.459519404206299 2215 4661669
SGTC_3114 9122766 49.47 µM 0.100972117862799 0.456612584694421 no 1497 0.459786296877319 2089 17176985
SGTC_536 3852-0578 10.6 µM 0.100453581577858 0.456845053328117 no 1498 0.45999211644964 2206 2869208
SGTC_1767 st044992 70.3 µM 0.100266872278598 0.456928761902366 no 1499 0.46006622850694 2154 9600693
SGTC_869 0564-0080 44.1 µM 0.0992398414841389 0.457389251258547 no 1500 0.460473921022329 2059 6843321
SGTC_411 enrofloxacin 100 µM 0.0992085749729544 0.457403271111271 no 1501 0.460486333302757 2245 71188 A bacterial gyrase inhibitor.
SGTC_479 n-linoleoylglycine 10 µM 0.0986725388378122 0.457643637072049 no 1502 0.460699136634312 2108 6433346 An anti-infammatory.
SGTC_202 3594-0513 34.79 µM 0.0981799793995669 0.457864521146689 no 1503 0.460894689886621 2245 708429
SGTC_2403 6032726 181.2 µM 0.0978851568515861 0.457996738031679 no 1504 0.461011743248362 2153 2881040
SGTC_1856 st057054 55.7 µM 0.0974587045805588 0.458187994144229 no 1505 0.461181063518053 2231 1266018
SGTC_767 0929-0023 86 µM 0.0971475195545299 0.458327561099177 no 1506 0.461304622075031 2242 1204563
SGTC_114 0364-0001 490.298 µM 0.0957258178043146 0.458965261583346 no 1507 0.461869167707076 2077 4003655
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.0953966185751941 0.459112938127458 no 1508 0.461999900908518 2233 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1301 naphtanilide LB 4.81 µM 0.0945027701398391 0.459513940880854 no 1509 0.462354891021019 2236 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1292 0kpi-0043 232 µM 0.0943490467393744 0.459582909203785 no 1510 0.462415944990972 2132 3333905
SGTC_899 1083-0020 478 µM 0.0939885746071123 0.459744640541121 no 1511 0.462559116350281 2217 767123
SGTC_683 panaxydol 45 µM 0.0936718755195547 0.459886737930286 no 1512 0.462684906052119 2209 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2091 4-phenylthiadiazole 200 µM 0.0932850879596566 0.460060289750078 no 1513 0.462838539252983 2175 270010
SGTC_1641 st009299 47.1 µM 0.0931330011671341 0.460128533275108 no 1514 0.462898950111417 2245 4046054
SGTC_1472 k841-0093 193 µM 0.0916818994979317 0.46077972218656 no 1515 0.463475389461306 2218 X1472
SGTC_1846 st056244 14.8 µM 0.0911679289594447 0.461010394275312 no 1516 0.463679578891855 2168 5393182
SGTC_2060 5238662 140 µM 0.0903987560228692 0.461355626732827 no 1517 0.463985172598594 2158 790130
SGTC_344 k064-0035 6.43 µM 0.0897245787399167 0.461658245686395 no 1518 0.464253041852647 2122 5088750
SGTC_1051 3253-3903 78 µM 0.0894128121379431 0.461798196339347 no 1519 0.464376920820649 2241 5509239
SGTC_1721 st082152 9.2685 µM 0.0891843197499612 0.461900768569623 no 1520 0.46446771337162 2253 5296051
SGTC_927 2425-1185 123 µM 0.0887489328600374 0.46209622455932 no 1521 0.464640721567186 2247 730375
SGTC_691 1548-0686 185 µM 0.0864274569544573 0.463138546139419 no 1522 0.465563310547247 2177 46495133
SGTC_2208 7283366 200 µM 0.0863770730510723 0.463161170886282 no 1523 0.465583335928623 2226 898663
SGTC_1792 st045773 43.6 µM 0.0862977153437892 0.46319680647805 no 1524 0.465614877297005 2135 2919270
SGTC_2896 9052656 71.43 µM 0.0857762030995287 0.463430998973263 no 1525 0.46582216195945 2234 6469436
SGTC_3037 9091026 49.47 µM 0.0856889488821415 0.463470182961129 no 1526 0.465856843664846 2259 25236398 YIL048W NEO1
SGTC_397 arbidol 50 µM 0.0855397326635887 0.463537193568884 no 1527 0.46591615455555 2241 131410 A RNA synthesis inhibitor.
SGTC_1952 st077036 64.1 µM 0.0846789176938505 0.463923791889886 no 1528 0.466258328500004 2273 2937007
SGTC_2089 5281248 129.67 µM 0.0842639927557053 0.464110149915286 no 1529 0.466423270084561 2211 2737878
SGTC_1678 st019265 80.2 µM 0.0836196763401166 0.464399551669158 no 1530 0.46667941113418 2264 5367020
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.0834875671616907 0.464458892281163 no 1531 0.466731931423187 2230 688751
SGTC_1390 3413-2614 145 µM 0.0826961266305126 0.464814406916541 no 1532 0.46704658241294 2174 3421432
SGTC_3295 9122362 53.5725 µM 0.0826311504935622 0.464843595411792 no 1533 0.467072415727131 2140 4730473
SGTC_1258 0671-0043 57.1 µM 0.0823512072047747 0.464969353331128 no 1534 0.467183717602617 2175 4298767
SGTC_316 k060-0003 58.6 µM 0.0822887130868247 0.464997427817729 no 1535 0.467208564816236 2241 6152314
SGTC_2705 st078069 42.8 µM 0.0822180439113662 0.46502917502855 no 1536 0.467236662528097 2183 1530061
SGTC_3336 9143619 71.43 µM 0.0808413777361363 0.46564766861729 no 1537 0.467784050532058 2270 45595730
SGTC_1452 4194-0072 190 µM 0.076845424601198 0.467443391628641 no 1538 0.469373256972185 2267 1343545
SGTC_2144 5628481 200 µM 0.0762904276597354 0.467692852401394 no 1539 0.469594020635653 2226 2818399
SGTC_1597 7-benzyloxygramine 47.5 µM 0.0758076271007107 0.467909872570307 no 1540 0.46978607402002 2235 260807
SGTC_1903 st060211 78.3 µM 0.0743998209020324 0.468542739518092 no 1541 0.470346125654698 2263 688960
SGTC_123 0083-0120 66.675 µM 0.0739762718350385 0.468733157922253 no 1542 0.470514632924705 2188 16001701
SGTC_2164 5685496 200 µM 0.0735023289621232 0.468946240758259 no 1543 0.470703195423104 2270 759046
SGTC_3054 9094397 49.47 µM 0.0734107376956672 0.468987420855938 no 1544 0.470739636603258 2250 2598354
SGTC_1569 carminic acid 40.6 µM 0.0732944299400697 0.469039714144497 no 1545 0.470785912022068 2279 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2506 ethyl hematommate 54.16 µM 0.0727446701778414 0.469286899594484 no 1546 0.471004650513615 2084 3940691 An allergen.
SGTC_1587 estradiol valerate 56.1 µM 0.0723820665170412 0.469449941563722 no 1547 0.471148928101034 2285 13791 A steroid.
SGTC_1283 0922-0125 16.4 µM 0.0715432307368589 0.469827137259008 no 1548 0.471482709765741 2257 3360884
SGTC_580 1123-0028 41 µM 0.0713097694761779 0.469932121616263 no 1549 0.471575610053959 2263 1677248 YPR107C YTH1
SGTC_1773 st048542 73.5835 µM 0.071177245336392 0.469991716852003 no 1550 0.471628345533405 2202 3237138
SGTC_2885 9057732 51.95 µM 0.0710419808841714 0.470052545081426 no 1551 0.471682171981418 2211 6471414
SGTC_133 0724-0033 378.92 µM 0.0706298200454967 0.470237897520312 no 1552 0.471846188353999 2291 280309
SGTC_1849 st056239 19.2 µM 0.069309935064066 0.470831504869862 no 1553 0.472371458859876 2138 5393181
SGTC_3017 9080681 49.47 µM 0.0688584290326622 0.471034580916596 no 1554 0.472551154382492 2191 16451914
SGTC_64 000l-0018 272.079 µM 0.0684795626250674 0.471204991303323 no 1555 0.472701944271112 2222 6811119
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.0682046222506706 0.471328660084866 no 1556 0.472811373759114 2206 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_3263 9137018 49.47 µM 0.067597816383245 0.471601612458429 no 1557 0.473052896849434 2197 43844957
SGTC_44 0929-0055 61.211 µM 0.0660455830777996 0.472299895782299 no 1558 0.47367076730224 2237 1379590
SGTC_49 0717-0965 32.132 µM 0.0657962068825785 0.472412087452955 no 1559 0.473770038081702 2244 5889349 YGL099W LSG1
SGTC_2021 4019055 173 µM 0.0655420537095327 0.472526430486687 no 1560 0.473871212139238 2263 44827708 YER133W GLC7
SGTC_2264 7948757 110.76 µM 0.0652104951919505 0.472675601441126 no 1561 0.474003202480979 2294 2971411
SGTC_1451 4152-0210 104 µM 0.0632777379965563 0.473545240709312 no 1562 0.474772671367895 2301 659563
SGTC_2172 5754775 163.918 µM 0.0628258769693308 0.473748572787198 no 1563 0.47495257986348 2229 2263357
SGTC_718 1130-0073 349 µM 0.0627086575604617 0.47380132124378 no 1564 0.47499925161408 2247 6740020
SGTC_2657 nystatin 74.44 µM 0.0625388360891633 0.473877741318502 no 1565 0.475066867862483 2260 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3337 9144342 33.5465 µM 0.0625314813748499 0.473881050979552 no 1566 0.475069796237462 2279 17682949
SGTC_1881 5652484 16 µM 0.0624431135866337 0.473920817101043 no 1567 0.475104981124745 2289 2255129
SGTC_553 k007-0256 45.7 µM 0.0624324300862261 0.473925624768411 no 1568 0.475109234925006 2230 6287000
SGTC_756 0508-1999 28.3 µM 0.0623495441761668 0.473962924272101 no 1569 0.475142237323269 2220 6753853
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.0595154512370338 0.475238430120063 no 1570 0.47627077949217 2283 165506
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.0594961101603413 0.475247135610789 no 1571 0.476278481816605 2275 23847180
SGTC_3294 9122953 26.2835 µM 0.0586805677715236 0.475614224983184 no 1572 0.476603268667224 2306 16459826
SGTC_53 0973-0023 39.979 µM 0.0578729634598721 0.4759777616929 no 1573 0.476924909524909 2324 674768
SGTC_1213 1315-0166 115 µM 0.0569956865436523 0.476372683625225 no 1574 0.477274315598504 2119 768401
SGTC_173 1273-0061 2.693 µM 0.0567665043616837 0.476475857932687 no 1575 0.477365598270425 2229 2847414 YPL266W DIM1
SGTC_1130 3454-2858 15.9 µM 0.0564392591129608 0.476623181462501 no 1576 0.477495941266222 2159 715628 YIL048W NEO1
SGTC_3117 9124945 49.47 µM 0.0555326760983801 0.477031335441957 no 1577 0.477857049171916 2262 17592065
SGTC_127 0180-0333 59.125 µM 0.0553938203816056 0.47709385200283 no 1578 0.477912359450748 2314 771601
SGTC_1162 k048-0130 20.1 µM 0.0545186459358646 0.477487891878221 no 1579 0.478260976686362 2258 6797406
SGTC_636 0kpi-0074 126 µM 0.0542063779795512 0.47762849322618 no 1580 0.478385369632416 2247 616434
SGTC_1380 2291-0730 164 µM 0.0541304580237786 0.477662677264332 no 1581 0.478415612909951 2234 2999191
SGTC_3087 9117406 49.47 µM 0.0537857621777673 0.477817883527002 no 1582 0.478552926617664 2205 42546093
SGTC_2322 7413319 38.22 µM 0.0534516453329359 0.477968329592167 no 1583 0.47868602848383 2258 1840400
SGTC_1076 itraconazole 331 nM 0.0530445731778682 0.478151630200361 no 1584 0.478848196710756 2317 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2759 disulfiram 3.38 µM 0.0526294719888885 0.478338550963091 no 1585 0.479013567126807 2286 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3012 9080433 71.4286 µM 0.0525926410041706 0.478355136248127 no 1586 0.479028240242751 2302 17688859
SGTC_911 3456-4043 236 µM 0.0513917119265052 0.478895944524301 no 1587 0.479506694486159 2277 914281
SGTC_1078 idebenone 36.1 µM 0.05130476965688 0.478935098314172 no 1588 0.479541333737691 2255 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_600 1495-0418 41.6 µM 0.0511557885820919 0.479002191280509 no 1589 0.479600690643887 2283 5377768
SGTC_398 bronopol 33.3 µM 0.0502878660885754 0.479393068095702 no 1590 0.479946496497586 2219 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_3009 9080819 71.4286 µM 0.0497308181080386 0.479643950202479 no 1591 0.480168448768742 2250 17027216
SGTC_1014 4130-3005 69.3 µM 0.0491053481565648 0.479925657660127 no 1592 0.480417670669324 2314 743608
SGTC_1836 st055642 81 µM 0.0488813646759487 0.480026540758283 no 1593 0.480506919970629 2295 8571
SGTC_519 k048-0011 62.8 µM 0.047292559602076 0.480742181569109 no 1594 0.48114002901336 2231 6836379
SGTC_2925 9010536 32.5 µM 0.0469887145189385 0.480879048760074 no 1595 0.481261111051825 2270 2994177
SGTC_312 4092-0653 6.84 µM 0.0464014497055116 0.481143588904363 no 1596 0.481495140530673 2276 1148278
SGTC_1443 4112-3303 14 µM 0.0461594884237364 0.481252585550088 no 1597 0.481591565794883 2319 704433
SGTC_2056 5235370 200 µM 0.0458900790367843 0.481373948431765 no 1598 0.481698930814884 2290 5511916
SGTC_228 caffeine 993.056 µM 0.0457035917141633 0.481457957796443 no 1599 0.481773250514433 2331 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_446 go6976 132 µM 0.0456364053212335 0.481488224324854 no 1600 0.48180002606913 2310 3501 A protein kinase C inhibitor.
SGTC_946 3434-1334 87.4 µM 0.0450965268630956 0.481731435862746 no 1601 0.482015184884861 2296 4047976
SGTC_1936 st074407 74.3 µM 0.0446892029371229 0.481914936999296 no 1602 0.482177519954622 2327 809813
SGTC_1749 st037932 54.2 µM 0.0443532437703208 0.482066290897768 no 1603 0.482311415504522 2246 594497
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.0431985773000889 0.482586502473672 no 1604 0.482771619590872 2326 1377
SGTC_1752 st044819 83.042 µM 0.0428989778499021 0.482721485813937 no 1605 0.482891031779841 2287 441209 YML126C ERG13
SGTC_1565 sinapyl alcohol 95.1 µM 0.0382361063690441 0.484822569627197 no 1606 0.484749716607262 2292 5280507 A phenol propionate derived from cinnamic acid.
SGTC_3272 9137413 49.47 µM 0.0376493116312758 0.485087009632268 no 1607 0.484983645386416 2344 17614870
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.0367378427932865 0.485497777513287 no 1608 0.48534701740609 2325 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1608 st001473 40.5 µM 0.0367109635401651 0.485509891310552 no 1609 0.485357733447923 2301 7292267
SGTC_3049 9092223 49.47 µM 0.0366767527972174 0.485525309243569 no 1610 0.485371372374644 2300 8623917
SGTC_79 0052-0007 94.094 µM 0.0366278895647837 0.485547330727562 no 1611 0.485390852894627 2336 2801472
SGTC_459 nigericin 15.3 µM 0.0364177406653307 0.485642040285302 no 1612 0.485474634278341 2295 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3038 9091290 49.47 µM 0.0362894766771989 0.485699846485272 no 1613 0.485525770404693 2334 25236843
SGTC_1364 1653-0028 37.6 µM 0.0361567682126348 0.485759656044602 no 1614 0.485578678699874 2297 5718652
SGTC_1821 st053465 65.6 µM 0.0359753722370615 0.485841408795881 no 1615 0.485650998173437 2304 675086
SGTC_575 k072-0246 11.9 µM 0.0354806443777139 0.486064379070446 no 1616 0.485848240102898 2340 6796779
SGTC_595 3909-8003 73.7 µM 0.034957626568747 0.486300104157188 no 1617 0.486056764652188 2305 699517
SGTC_2768 sulfasalazine 50.2 µM 0.033782056942053 0.486829952892899 no 1618 0.486525472132289 2345 5384001 An antioxidant and salicylic acid derivative.
SGTC_1845 st056753 3.01 µM 0.0336800292633167 0.486875939570414 no 1619 0.486566152137992 2337 5375839
SGTC_3306 9127676 59.7925 µM 0.0335985217870101 0.486912677354427 no 1620 0.486598650523647 2293 41905287
SGTC_1945 st075991 56.6 µM 0.0332373670715168 0.487075461593429 no 1621 0.486742649979843 2260 1084980
SGTC_1800 st050079 29.0735 µM 0.0332148720828666 0.487085600891858 no 1622 0.486751619229632 2325 3645560
SGTC_1448 4255-0083 152 µM 0.0330288717982142 0.487169438212478 no 1623 0.486825781915682 2349 5399660
SGTC_2676 harmalol 100 µM 0.0325376681658885 0.487390844871703 no 1624 0.487021638534907 2342 5459187 A monoamine oxidase inhibitor
SGTC_2529 gangaleoidin 93.61 µM 0.0318959365268172 0.487680106839585 no 1625 0.48727751958722 2345 4565183
SGTC_2719 novobiocin 32.65 µM 0.030787956564232 0.488179546447868 no 1626 0.487719322568822 2345 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2429 5902844 64.44 µM 0.0295250250895576 0.488748855480158 no 1627 0.488222930251872 2349 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2772 vinpocetine 57.06 µM 0.0288501101351102 0.489053105672078 no 1628 0.48849206769236 2338 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1151 3909-8316 15.3 µM 0.0287276515850839 0.489108310407749 no 1629 0.488540901344681 2287 800431
SGTC_1995 st072814 61.1 µM 0.0284938320428439 0.48921371764053 no 1630 0.488634143675142 2322 5769371
SGTC_1676 st018489 23.4 µM 0.0284669974325154 0.489225814889935 no 1631 0.488644844794879 2243 3696235
SGTC_2437 5741531 144.16 µM 0.028118854469351 0.489382761318589 no 1632 0.488783678163349 2349 2262990
SGTC_295 k015-0027 31 µM 0.0276281164952826 0.489603993831158 no 1633 0.488979378250321 2319 3887424
SGTC_1559 coumarin 343 70.1 µM 0.0255411780337778 0.490544853904041 no 1634 0.489811651934266 2348 108770 A hepatotoxic, DNA x-linker.
SGTC_132 0417-1715 25.805 µM 0.0236584947501091 0.491393674352986 no 1635 0.490562506560922 2366 6769098
SGTC_3217 9129673 49.47 µM 0.0231633105659207 0.491616938110818 no 1636 0.490760002338356 2353 17248312
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.0223215550331157 0.491996466527246 no 1637 0.491095727367462 2367 23665772 A membrane-active detergent.
SGTC_1070 indatraline 8.81 µM 0.0220767829004058 0.49210683008738 no 1638 0.491193353261884 2336 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2596 sinensetin 100 µM 0.0217643534812887 0.49224770003525 no 1639 0.491317964624124 2341 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2074 5212007 75.395 µM 0.0215869596503295 0.49232768480298 no 1640 0.49138871790038 2376 758611
SGTC_2882 9058044 58.44 µM 0.0212980681426745 0.492457943205331 no 1641 0.491503942444736 2350 18076804
SGTC_2489 cantharidin 73.42 µM 0.0211550706167573 0.492522419712905 no 1642 0.49156097735329 2358 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2902 5787006 60.46 µM 0.0209042040755434 0.492635534018138 no 1643 0.491661036495249 2348 591003
SGTC_2781 5567276 71.43 µM 0.0204542329608526 0.492838424927637 no 1644 0.491840510617976 2363 2853274
SGTC_833 3852-0053 558 µM 0.019769776460026 0.493147048277202 no 1645 0.492113514030391 2344 3123681
SGTC_688 0527-0193 473 µM 0.0196346359705761 0.493207983992431 no 1646 0.49216741682246 2357 4007154
SGTC_264 promethazine 12.5 mM 0.0184374690955827 0.493747800988771 no 1647 0.492644930750572 2374 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_877 0771-0151 33.1 µM 0.0175672158607398 0.494140215921243 no 1648 0.492992055296283 2292 6166523
SGTC_2950 9072895 21.46 µM 0.0165831256133072 0.494583969096102 no 1649 0.493384593259236 2348 17332245
SGTC_1482 3346-2049 8.48 µM 0.0164541766271517 0.49464211622486 no 1650 0.493436029443726 2376 3826804
SGTC_2066 5222451 176 µM 0.0159648100602968 0.494862787932578 no 1651 0.493631232809612 2380 2281147
SGTC_529 4076-0302 30.3 µM 0.0159627562391142 0.494863714072414 no 1652 0.493632052061321 2353 5816522
SGTC_2195 6536160 144.242 µM 0.0155264933655148 0.495060440886782 no 1653 0.4938060741948 2382 3834386
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.0151606003196372 0.495225436311845 no 1654 0.493952027218626 2363 5393153
SGTC_3080 9117754 49.47 µM 0.0149490442188614 0.495320835571761 no 1655 0.494036416327906 2388 9550191
SGTC_1567 st069303 68.4 µM 0.0147194304033938 0.495424378093156 no 1656 0.49412800890862 2352 5581319
SGTC_584 0986-0246 15.4 µM 0.0136972612580546 0.495885320771634 no 1657 0.494535754221373 2377 53315 YDR232W HEM1
SGTC_1202 1988-0068 29.6 µM 0.0132623676927767 0.496081435812904 no 1658 0.494709235888676 2364 2850480
SGTC_1730 st033808 45.1 µM 0.0128638125901543 0.496261164874942 no 1659 0.494868222803444 2338 1045166
SGTC_402 epigallocatechin gallate 10 µM 0.0127004764311128 0.496334821798844 no 1660 0.494933379180184 2362 65064 An antioxidant.
SGTC_2057 5236571 38.335 µM 0.0114644341627765 0.496892222586947 no 1661 0.495426452677841 2374 54684039 YBR257W POP4
SGTC_2302 7771753 200 µM 0.0114306235793288 0.496907469765659 no 1662 0.495439940265327 2369 2203047
SGTC_2420 aureobasidin a 50 nM 0.011323332574341 0.496955853613795 no 1663 0.495482740413482 2376 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.0112532943492438 0.49698743800844 no 1664 0.495510679842549 2390 66535 A nucleotide analog.
SGTC_1925 st057770 10.1 µM 0.0108397091862829 0.497173948495958 no 1665 0.495675666382861 2382 5989122
SGTC_1414 3917-0015 5.4 µM 0.0105917852872574 0.497285752629589 no 1666 0.495774568029786 2382 6618702
SGTC_2258 7960471 200 µM 0.0103840710547589 0.497379423916141 no 1667 0.495857429461857 2364 2974708
SGTC_154 3389-1638 511.116 µM 0.00990701376385219 0.497594559304396 no 1668 0.496047737988895 2354 5238686
SGTC_2543 pimpinellin 60.67 µM 0.00969946199482931 0.49768815778239 no 1669 0.496130535186137 2392 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_919 tnp00227 403.569 nM 0.00956439576858734 0.497749067923113 no 1670 0.496184416314955 2384 1269246 A methoxyflavone. YNL221C POP1
SGTC_1844 rapamycin 4 nM 0.00940893708758917 0.497819174412061 no 1671 0.496246432564902 2385 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2737 bleomycin 30.5 nM 0.0092508667244669 0.49789045874837 no 1672 0.496309490771389 2389 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2624 nerol 100 µM 0.00788627135404564 0.49850584722483 no 1673 0.496853865533588 2389 637566 A natural product oil.
SGTC_1754 st042065 16.137 µM 0.0069301658219822 0.498937022171444 no 1674 0.497235285973681 2384 1126236 YIL048W NEO1
SGTC_2432 5630864 12.22 µM 0.00629078871589119 0.499225362812117 no 1675 0.497490354956961 2396 5714970
SGTC_2123 5259487 200 µM 0.00543266818088093 0.49961235104155 no 1676 0.497832689628218 2396 2173474
SGTC_3179 9107801 49.47 µM 0.0052031582027131 0.499715853664377 no 1677 0.497924249567406 2394 4818259
SGTC_1057 3448-5381 134 µM 0.00463623118053046 0.499971522065686 no 1678 0.49815041798639 2393 5497911
SGTC_849 0386-0493 241 µM 0.00450993548724767 0.499971522065686 no 1679 0.498200802151392 2395 726119
SGTC_951 1171-0579 82.7 µM 0.00408407226105325 0.499779469526603 no 1680 0.498370695428223 2390 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3089 9117425 49.47 µM 0.00349052209065742 0.499511794907551 no 1681 0.498607485985035 2394 9401657
SGTC_2724 maprotiline 69.64 µM 0.00338683751445971 0.499465036066506 no 1682 0.498648849901732 2389 4011 A tricyclic antidepressant.
SGTC_1487 3970-0795 2.82 µM 0.0033417717246578 0.49944471265925 no 1683 0.498666828448936 2399 3765103
SGTC_786 4544-0069 423 µM 0.00327063544847275 0.499412632196779 no 1684 0.498695207562065 2389 748821 YLR208W SEC13
SGTC_2917 7979103 53.79 µM 0.00299971514712278 0.499290454787081 no 1685 0.498803288593379 2391 2980565
SGTC_1214 0358-0031 63.7 µM 0.00277894115939778 0.499190891998233 no 1686 0.498891364303678 2397 4301366
SGTC_975 1335-0046 28.5 µM 0.00270429156933976 0.499157227167514 no 1687 0.498921145069436 2398 16486740
SGTC_1557 sumaresinolic acid 42.3 µM 0.00187133788915901 0.498781589335882 no 1688 0.499253444630825 2400 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3255 9139072 49.47 µM 0.00142731110204795 0.498581346617181 no 1689 0.499430585447444 2396 17646060
SGTC_3058 9093861 49.47 µM 0.00130352030198464 0.498525520753191 no 1690 0.499479970785446 2399 17217477
SGTC_3165 9101544 49.47 µM 0.000547005532669149 0.498184356402357 no 1691 0.499781776376287 2403 5002184
SGTC_1820 st053765 18.6 µM 0 0.497937674936079 no 1692 0.5 2405 3690829
SGTC_2980 9014342 25.29 µM 0 0.497937674936079 no 1693 0.5 2406 2996599
SGTC_3204 9114183 49.47 µM 0 0.497937674936079 no 1694 0.5 2405 17027248
SGTC_270 tamoxifen 5.46 µM -0.000375913872413326 0.49776815062095 no 1695 0.499850032066037 2407 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2849 9019321 12.99 µM -0.00118192223071696 0.497404669782622 no 1696 0.499528481359801 2412 16489627
SGTC_3104 9120930 49.47 µM -0.00169567506059048 0.497172986802529 no 1697 0.499323523848688 2411 17014836
SGTC_2848 9016370 25.97 µM -0.00222464627811231 0.496934441905667 no 1698 0.499112495272774 2411 7894410
SGTC_640 3381-0960 37.1 µM -0.00224487626070751 0.496925319012533 no 1699 0.499104424697538 2411 1745025
SGTC_2975 9084847 53.72 µM -0.00249155463111961 0.49681407730704 no 1700 0.499006014542134 2426 27211724
SGTC_275 trichlorophene 5.69 µM -0.00251347142504608 0.496804193754596 no 1701 0.498997271033765 2420 62616
SGTC_2854 9024559 71.43 µM -0.00413863113034382 0.496071320944264 no 1702 0.49834892977245 2415 3163529
SGTC_445 e6 berbamine 66 µM -0.00415954854448162 0.496061888226851 no 1703 0.498340585003382 2417 6610268 A calcium/calmodulin antagonist.
SGTC_837 0091-0265 12.5 µM -0.0045286673270002 0.495895434311164 no 1704 0.498193329304839 2413 759367
SGTC_2769 toremifene 3.73 µM -0.00466610335657995 0.495833457788848 no 1705 0.498138500841261 2417 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_740 k014-0057 261 µM -0.00675933585772396 0.494889531786353 no 1706 0.497303435672654 2422 4012779
SGTC_1145 3546-0597 10.2 µM -0.00691718622264053 0.494818351555022 no 1707 0.49724046396053 2426 875334
SGTC_1860 st056228 74.6 µM -0.00732149794690704 0.494636034064299 no 1708 0.497079171007978 2449 688679
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0079318807084819 0.494360794481358 no 1709 0.49683567060281 2456 61125 An anti-inflammatory.
SGTC_1954 st077032 68.9 µM -0.00838208428117375 0.494157786130118 no 1710 0.496656071339432 2436 698907
SGTC_2722 naftopidil 47.16 µM -0.00908883547894023 0.493839096939212 no 1711 0.49637412916825 2420 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1843 st055809 45.5 µM -0.00949011513365798 0.493658153120176 no 1712 0.496214048655963 2454 16413835
SGTC_2710 st078562 53.7235 µM -0.0098189149078176 0.493509892682538 no 1713 0.496082882637968 2419 17250908
SGTC_2778 tioconazole 65.09 nM -0.0115248390318248 0.492740682378816 no 1714 0.495402356213585 2423 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.0123052020489488 0.492388821349844 no 1715 0.495091058517786 2438 521171
SGTC_1402 3909-7673 35.9 µM -0.0129877038149227 0.492081090220459 no 1716 0.494818801484456 2424 5328014
SGTC_2836 9010338 19.48 µM -0.0143292525599972 0.491476217327234 no 1717 0.494283650928527 2438 2994051
SGTC_2294 7971431 200 µM -0.0148537285722425 0.491239748635541 no 1718 0.494074437547746 2449 5741572
SGTC_2712 st079126 47.7 µM -0.0149144945938658 0.491212351466277 no 1719 0.494050198097626 2431 3152970
SGTC_1545 lovastatin 49.4 µM -0.0155408239366683 0.490929964988773 no 1720 0.493800357813772 2439 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1071 trifluoperazine 6.31 µM -0.0158728106750787 0.490780287478395 no 1721 0.493667930604072 2460 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1084 voriconazole 435 nM -0.0168537426774639 0.490338038140784 no 1722 0.49327664775764 2435 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2297 7971671 152.32 µM -0.0169879776728954 0.49027751973248 no 1723 0.49322310340833 2454 909016
SGTC_2276 7947513 42.08 µM -0.0170299144318656 0.490258613040201 no 1724 0.49320637548198 2475 2105100
SGTC_26 0302-0163 425.158 µM -0.0171970096349777 0.490183280359956 no 1725 0.493139723901542 2439 3100915
SGTC_1018 4259-0013 28.1 µM -0.0180034057458315 0.489819732223201 no 1726 0.49281806822995 2514 6801262
SGTC_2776 terbinafine 19.92 µM -0.0180245334714037 0.489810207307914 no 1727 0.492809640854396 2425 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_418 lividomycin a 100 µM -0.0184124810697505 0.489635311716124 no 1728 0.492654897838624 2433 72394 An antibiotic.
SGTC_2192 5915882 198.485 µM -0.0184561324538478 0.489615632804493 no 1729 0.492637486414569 2442 2876149
SGTC_1407 3909-7909 12.3 µM -0.0203031119867161 0.488783001485256 no 1730 0.491900786646633 2448 4411780
SGTC_3127 9126946 49.47 µM -0.0205082408498804 0.488690530905704 no 1731 0.491818969106172 2477 27243249
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.0207494104010725 0.488581814227551 no 1732 0.4917227768451 2446 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_864 0469-0573 172 µM -0.021216360935621 0.488371320293328 no 1733 0.491536531540398 2448 689425
SGTC_3194 9111903 49.47 µM -0.0217777192857204 0.488118273098154 no 1734 0.491312633703144 2474 17087251
SGTC_1479 0549-0158 134 µM -0.0222570352483875 0.487902212471202 no 1735 0.491121460644405 2453 5440202
SGTC_1340 1486-1359 257 µM -0.0229345999140773 0.487596793608736 no 1736 0.490851220453928 2483 4309068
SGTC_1378 2093-0007 380 nM -0.0231562255303487 0.487496895276905 no 1737 0.490762828100669 2465 3618014
SGTC_1889 st059080 5.18 µM -0.0234874535818585 0.487347594822252 no 1738 0.490630723158436 2451 176925 Isolated from Daphnopsis sellowiana.
SGTC_2156 5649887 115 µM -0.0237819620575034 0.48721484713966 no 1739 0.490513264086856 2478 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2185 6113692 200 µM -0.0238786970203744 0.487171244824614 no 1740 0.49047468337644 2482 874150
SGTC_754 3474-0146 171 µM -0.0239915209279285 0.487120390772759 no 1741 0.490429686040595 2451 24762078
SGTC_1372 2752-0194 270 µM -0.0243478306880287 0.486959789710201 no 1742 0.490287580526304 2457 823334
SGTC_1207 2099-0101 141 µM -0.0247252798312444 0.486789662707941 no 1743 0.490137045426356 2451 5837381
SGTC_643 k048-0106 28.4 µM -0.0247715769708443 0.486768795442847 no 1744 0.490118581195305 2495 6763920
SGTC_1067 clotrimazole 1.36 µM -0.0260176507951333 0.486207172966469 no 1745 0.489621629958822 2466 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2900 5328528 85.29 µM -0.0267328397628342 0.485884839824192 no 1746 0.489336410071577 2439 795359
SGTC_883 0850-0245 24.6 µM -0.026848909722278 0.485832528367575 no 1747 0.489290121472121 2572 6823229 YPR165W RHO1
SGTC_2412 st077135 33.4 µM -0.0269560367716027 0.485784247598708 no 1748 0.489247399425481 2624 13258915
SGTC_571 k831-0106 44.2 µM -0.0277670068934332 0.48541876071443 no 1749 0.488923990247866 2461 4783639
SGTC_627 1391-0720 175 µM -0.0303711763786001 0.484245201587449 no 1750 0.487885516082535 2485 997839
SGTC_3242 9133940 49.47 µM -0.0315006065407004 0.483736269986743 no 1751 0.487435154218375 2555 17248444
SGTC_562 3772-2733 112 µM -0.0319157297040488 0.483549218293078 no 1752 0.487269627270101 2470 2876874 YIL048W NEO1
SGTC_2908 7930301 100 µM -0.0323524333704823 0.483352446479007 no 1753 0.487095497641207 2458 2223178
SGTC_2279 7948423 32.93 µM -0.0325198672692357 0.483277004466307 no 1754 0.487028736309066 2454 1247112
SGTC_2428 5615643 7.78 µM -0.033220967255192 0.482961110847999 no 1755 0.486749188948878 2495 2253075
SGTC_1275 0867-0008 21.1 µM -0.0334318611701882 0.482866090761787 no 1756 0.486665101158678 2477 3422836
SGTC_1798 st045719 60.953 µM -0.0337847699684749 0.482707086815261 no 1757 0.486524390408814 2458 3980186
SGTC_276 colchicine 750 µM -0.0353625622445829 0.481996242531419 no 1758 0.485895318514665 2534 2833 A microtubule depolymerizer.
SGTC_248 streptozotocin 5.23457 mM -0.0361182793629301 0.481655788698125 no 1759 0.485594023506523 2529 5300 DNA alkylating agent.
SGTC_1818 st052136 56.3 µM -0.0369859035711462 0.481264936747692 no 1760 0.485248122685734 2490 674169
SGTC_1020 4335-0961 93.3 µM -0.0370642585004694 0.481229639884977 no 1761 0.485216885010084 2463 669075
SGTC_1780 st038448 24.544 µM -0.0375211333159878 0.481023832573699 no 1762 0.485034745030101 2598 728868 YDL195W SEC31
SGTC_2511 berberine 10.47 µM -0.039761046690373 0.480014898338087 no 1763 0.484141815947368 2486 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2571 chrysanthemic acid 100 µM -0.0398310514868669 0.479983367792875 no 1764 0.48411391018051 2519 2743 An insecticide.
SGTC_1907 st060210 83.7 µM -0.0406113671470181 0.479631917853329 no 1765 0.483802860980535 2476 688793
SGTC_602 3130-1533 38.1 µM -0.04087539576503 0.479513004367935 no 1766 0.483697616192533 2533 720941
SGTC_3200 9114385 49.47 µM -0.0413557361098246 0.479296672864065 no 1767 0.483506150026063 2520 17018030 YLR208W SEC13
SGTC_2594 a-mangostin 100 µM -0.0415671222379183 0.479201472548181 no 1768 0.483421891615581 2526 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_351 caspofungin 25 nM -0.0419373918340602 0.479034719991111 no 1769 0.48327430411648 2499 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3254 9136651 49.47 µM -0.0422765204427817 0.478881995134933 no 1770 0.483139131260195 2489 16454030
SGTC_1919 st067113 52.3 µM -0.0424398505266808 0.478808441361439 no 1771 0.48307403041283 2533 1268243
SGTC_2055 5235184 200 µM -0.0425831120004774 0.47874392584345 no 1772 0.483016928974751 2519 2836034
SGTC_493 zm226600 134 µM -0.0438396352525186 0.478178094705279 no 1773 0.482516116538651 2578 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2261 9010538 184.68 µM -0.0438411307902488 0.478177421268341 no 1774 0.482515520478502 2567 6457250
SGTC_2194 5927483 104.545 µM -0.0439341445434758 0.478135537527998 no 1775 0.482478449078961 2473 760979
SGTC_768 0384-0033 77.3 µM -0.0442291419015309 0.478002702936 no 1776 0.482360876449218 2495 3965305 YMR134W ERG29
SGTC_905 2-aminofluorene 215 µM -0.0453765215208758 0.477486071837277 no 1777 0.48190359740951 2486 1539 An established DNA mutagen. YPR165W RHO1
SGTC_857 0438-0306 1.35 µM -0.0455507656083284 0.477407618167145 no 1778 0.481834155878939 2543 4686136
SGTC_1691 st019933 84.6 µM -0.0458849948942239 0.477257133366859 no 1779 0.481700956959995 2477 6176082
SGTC_2977 9011197 71.43 µM -0.0477523517447051 0.476416427036332 no 1780 0.480956805500442 2630 2704722
SGTC_2749 bexarotene 57.39 µM -0.0482691676495751 0.476183768736629 no 1781 0.48075086327574 2524 82146 An retinoic acid receptor inhibitor.
SGTC_2260 7964312 200 µM -0.0496537407039096 0.47556050691777 no 1782 0.480199160262394 2635 231951
SGTC_2408 sulbentine 18.36 µM -0.0499323182240868 0.475435113176549 no 1783 0.480088161598945 2625 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_19 0279-0214 38.434 µM -0.0501685717346735 0.475328772289628 no 1784 0.479994028063235 2512 3566274 YBR002C RER2
SGTC_1123 mangostin 811.285 nM -0.051035052803149 0.474938772591014 no 1785 0.479648794416563 2558 5281650 An antioxidant.
SGTC_1399 3562-5772 25 µM -0.0521464792695283 0.474438559143264 no 1786 0.479205989109498 2497 23847490
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.0526965339196729 0.474191014002316 no 1787 0.478986850360946 2501 688669
SGTC_235 0330-0087 5 mM -0.052978865295135 0.474063958200187 no 1788 0.478874373555837 2499 46494818 YHR062C RPP1
SGTC_325 2810-4341 181 µM -0.0532587534635715 0.473938004502958 no 1789 0.478762871750232 2508 774970
SGTC_1005 4092-0690 4.4 µM -0.0533792704886945 0.473883770911722 no 1790 0.478714860707664 2523 1529343
SGTC_3332 9141069 11.198 µM -0.0541401492085156 0.473541380832137 no 1791 0.478411752347701 2508 17332883
SGTC_794 k038-0031 316 µM -0.0551101534676647 0.473104914103572 no 1792 0.478025353570983 2490 6624242
SGTC_66 0109-0187 42.4 µM -0.0556434934383181 0.472864944187993 no 1793 0.477812907701695 2491 759417
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.0558692718066855 0.4727633608841 no 1794 0.477722975063577 2687 5282309
SGTC_2699 st077704 54.6 µM -0.0562290678042194 0.472601483378724 no 1795 0.477579662514364 2546 645852
SGTC_405 ebelactone b 50 µM -0.0575381621653778 0.472012540975222 no 1796 0.477058253717723 2528 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1503 4585-0012 61.3 µM -0.0577685862965806 0.471908882825822 no 1797 0.476966480439508 2639 2922052
SGTC_1238 0333-0287 48.8 µM -0.0584268261994243 0.47161277881468 no 1798 0.476704323524709 2519 7226
SGTC_1658 st012944 20 µM -0.0586953697446121 0.471491981123238 no 1799 0.476597373695033 2548 24207260
SGTC_1483 3453-0561 55.9 µM -0.0589917970261393 0.4713586436663 no 1800 0.476479320879732 2581 4546991
SGTC_1910 st062352 60.4 µM -0.0593578523122689 0.471193990915683 no 1801 0.476333541408573 2502 2245730
SGTC_364 0083-0097 67.7 µM -0.05984452671643 0.47097509095848 no 1802 0.47613973095637 2593 5207356
SGTC_1092 toremifene 6.32 µM -0.0607783854146815 0.470555077807414 no 1803 0.475767852215832 2505 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1921 5740136 50 µM -0.061981995308336 0.470013789487579 no 1804 0.475288585046094 2491 1774243
SGTC_1602 st001878 87.6 µM -0.0632728915927764 0.46943330827341 no 1805 0.474774600936631 2688 595405 YLR310C CDC25
SGTC_2008 4012253 172 µM -0.0632804988991537 0.469429887664408 no 1806 0.474771572130131 2543 603940
SGTC_656 4090-1979 187 µM -0.0636465868385878 0.469265279678861 no 1807 0.474625817990541 2516 22330961
SGTC_755 1995-0008 37.3 µM -0.0645926161674459 0.468839930918969 no 1808 0.474249181939391 2502 689533
SGTC_1344 1488-0097 29.1 µM -0.0647510327537647 0.468768707944927 no 1809 0.474186114890484 2588 747966
SGTC_1259 0671-0132 43 µM -0.0649799502381093 0.46866579003327 no 1810 0.474094981951643 2548 X1259
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.0666487562345758 0.467915583271211 no 1811 0.473430665071856 2543 115019
SGTC_2196 6573537 42.6665 µM -0.0669297513102039 0.467789273907229 no 1812 0.473318814007251 2586 2903087
SGTC_2765 myclobutanil 7.74 µM -0.0672683059618353 0.467637095396766 no 1813 0.473184053948579 2593 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1217 1183-1422 255 µM -0.067376249356885 0.467588576409668 no 1814 0.473141088241334 2587 2849664
SGTC_311 1315-0136 58 µM -0.0678261051488369 0.467386377962988 no 1815 0.472962031352888 2634 6759207
SGTC_2567 aureobasidin a 60 nM -0.0680423309976791 0.467289193074124 no 1816 0.472875968541574 2708 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_99 0109-0120 622.8 µM -0.0682403555612499 0.467200190646977 no 1817 0.472797151366944 2529 759414
SGTC_1392 3455-1037 33.9 µM -0.0692225564032188 0.466758763379684 no 1818 0.472406234378725 2627 981132
SGTC_1824 st053723 68.6 µM -0.0692728364523657 0.466736167279344 no 1819 0.472386223577157 2559 675225
SGTC_1742 st038235 28.8875 µM -0.0701785174850897 0.466329168216057 no 1820 0.472025786362105 2620 564103 YBR002C RER2
SGTC_858 0438-0351 2.77 µM -0.072109721113419 0.465461433258058 no 1821 0.471257295018835 2544 2799119
SGTC_2619 obliquin 87.91 µM -0.0725153330086133 0.465279203073755 no 1822 0.47109590180837 2539 6708593 A bioactive alkalod. YER133W GLC7
SGTC_490 phenamil 164 µM -0.0733876005617523 0.464887342148465 no 1823 0.470748842153629 2618 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_174 3553-0389 74.3 µM -0.0735941976230522 0.464794534640959 no 1824 0.470666644123173 2615 738071
SGTC_2109 5483026 200 µM -0.0741263398336572 0.464555494611617 no 1825 0.4704549283776 2577 759335
SGTC_1433 4060-0023 7.6 µM -0.0747590284265946 0.464271305469851 no 1826 0.470203220565147 2617 3840627
SGTC_2393 9031399 185.94 µM -0.074848887005112 0.46423094454114 no 1827 0.470167472335946 2597 1526623 YDL150W RPC53
SGTC_574 1315-0397 40 µM -0.0750585369187479 0.464136779502138 no 1828 0.470084068734004 2545 6794277
SGTC_826 1683-5028 118 µM -0.0756066871199323 0.463890585304951 no 1829 0.469866008071538 2599 722377
SGTC_172 1112-0046 2.638 µM -0.0775117815875208 0.463035046205369 no 1830 0.469108209560381 2572 2802135 YIL048W NEO1
SGTC_271 rotenone 740 µM -0.0778756437598458 0.462871662441314 no 1831 0.46896348701152 2675 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3281 9140613 49.47 µM -0.0783643528579158 0.46265222895741 no 1832 0.468769114299711 2569 16013766
SGTC_1653 st012112 65 µM -0.0784333708986129 0.46262124033382 no 1833 0.468741664573175 2616 720429
SGTC_3010 9080089 71.4286 µM -0.0803011293268382 0.461782716455152 no 1834 0.467998880021747 2563 17027233
SGTC_1254 0550-0035 264 µM -0.083169206991862 0.460495434544942 no 1835 0.466858498574019 2629 15121435
SGTC_3137 9097352 49.47 µM -0.0837104638622287 0.460252547748791 no 1836 0.466643318695124 2679 44120435
SGTC_18 0111-0177 500 nM -0.0840496210564454 0.460100359903987 no 1837 0.466508489705632 2553 721752
SGTC_1887 st057648 70.8 µM -0.0842336545017737 0.460017782194685 no 1838 0.466435330419418 2670 688672
SGTC_1486 3970-0793 4.53 µM -0.0846569947062284 0.459827831621034 no 1839 0.466267043214207 2649 2844330
SGTC_2461 5755302 26.15 µM -0.0853134036609996 0.459533322442828 no 1840 0.466006117901463 2657 2788904
SGTC_605 1315-0399 119 µM -0.0859020532568777 0.459269233547035 no 1841 0.465772139641739 2650 24020461
SGTC_3240 9133527 49.47 µM -0.086757008579854 0.458885702581597 no 1842 0.465432330451005 2546 17617455
SGTC_1244 0416-0015 52.5 µM -0.0883441651397796 0.45817380957337 no 1843 0.464801568725477 2600 96201
SGTC_1282 0886-0010 32.4 µM -0.0884553381800817 0.458123949732818 no 1844 0.464757390054421 2592 2836211 YNL267W PIK1
SGTC_2585 alliin 100 µM -0.0885367966967146 0.458087416935459 no 1845 0.464725019811195 2635 87310 A garlic compound which reacts with lipids.
SGTC_2263 7948595 193.29 µM -0.0886562897987045 0.458033826896413 no 1846 0.464677535686499 2563 2971371
SGTC_2327 6189656 200 µM -0.0887865366589419 0.457975414901312 no 1847 0.464625778810328 2636 5349088
SGTC_2113 5491891 107.031 µM -0.0892246231741973 0.457778952284929 no 1848 0.464451698477339 2573 789979
SGTC_1293 1000-1278 195 µM -0.0898544982161421 0.457496499004186 no 1849 0.46420141999243 2639 678847
SGTC_1146 3579-1023 7 µM -0.0913919487619115 0.456807154355214 no 1850 0.4635905794674 2684 X1146
SGTC_2180 6301957 200 µM -0.0919660547128081 0.456549776449741 no 1851 0.46336250483825 2580 845462
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.0929256912936925 0.456119601746008 no 1852 0.46298129767602 2635 6728940
SGTC_188 3229-0966 278.469 µM -0.0935452896227818 0.455841882718256 no 1853 0.462735185745545 2595 5722370
SGTC_831 k061-1017 217 µM -0.0936148330816706 0.455810712994159 no 1854 0.46270756313341 2650 1240153
SGTC_1042 0350-0096 82 µM -0.0952206156911219 0.455091069275999 no 1855 0.462069797716377 2548 3122515
SGTC_391 gliotoxin 8.33 µM -0.0954288731663916 0.454997747845158 no 1856 0.46198709162649 2679 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1334 1486-0610 236 µM -0.0955938703507851 0.4549238133746 no 1857 0.461921566828643 2694 3742339
SGTC_2213 7173844 200 µM -0.0971568818391085 0.454223513010158 no 1858 0.461300904648889 2582 892728
SGTC_991 3996-0057 64.7 µM -0.0976660940250441 0.45399539337065 no 1859 0.461098719924837 2650 715343
SGTC_2965 9082772 38.63 µM -0.0978813160236258 0.453898981609488 no 1860 0.461013268194151 2626 16459634
SGTC_591 4299-0174 154 µM -0.0986033144174315 0.453575572015296 no 1861 0.460726619161901 2618 5509088
SGTC_1098 clofazimine 15.1 µM -0.0987413055572403 0.453513764213922 no 1862 0.460671836002723 2681 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1548 st061468 90.8 µM -0.0988137342073846 0.45348132304805 no 1863 0.460643081772095 2607 390799
SGTC_2376 9072922 81.32 µM -0.099245554557192 0.453287914936478 no 1864 0.460471653032329 2710 17087968
SGTC_628 1636-0253 16 µM -0.0995984836894049 0.453129849655833 no 1865 0.460331548840818 2647 4456143
SGTC_1980 st071811 45.7 µM -0.0999330370806328 0.452980021117069 no 1866 0.460198743913378 2732 4974850
SGTC_930 2810-3379 265 µM -0.100915863009531 0.45253990483836 no 1867 0.459808625266801 2723 1015764
SGTC_1384 3089-0840 101 µM -0.101858416743603 0.452117877491206 no 1868 0.459434528430659 2586 1069836
SGTC_2082 5219693 150 µM -0.103118028411315 0.451553972355263 no 1869 0.458934648347632 2585 2834649
SGTC_3019 9081971 49.47 µM -0.103236879209715 0.451500770052288 no 1870 0.4588874854468 2675 16451803
SGTC_2505 galangin 7.89 µM -0.103770141312181 0.451262071647787 no 1871 0.458675881147142 2569 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_115 0527-0192 112.043 µM -0.103816177588378 0.451241465747548 no 1872 0.458657613991834 2649 4233931
SGTC_1023 4482-3888 16 µM -0.104019569304347 0.451150428910385 no 1873 0.458576909377065 2720 3303168
SGTC_1829 berberine 14.4 µM -0.104056402237041 0.45113394299885 no 1874 0.458562294472471 2757 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3286 9117135 37.221 µM -0.104088423949109 0.451119610591654 no 1875 0.458549588653083 2622 3438150
SGTC_2618 avocadyne 43.43 µM -0.105263294394816 0.45059380154672 no 1876 0.458083443975111 2631 3015189
SGTC_897 1000-0139 31.4 µM -0.106425741653862 0.450073637778681 no 1877 0.457622285084831 2591 6151020
SGTC_2654 protoveratrine a 100 µM -0.106548812484271 0.450018571909292 no 1878 0.457573464514721 2595 5702278 A heart drug and vasodilator.
SGTC_799 1310-0557 151 µM -0.106586336280366 0.450001782740856 no 1879 0.457558579448593 2730 5354492
SGTC_1966 st070145 16.1 µM -0.107423882664652 0.449627065020639 no 1880 0.457226354253463 2577 3748532
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.108289288075457 0.449239930372347 no 1881 0.456883109762599 2651 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_292 k038-0015 474 µM -0.112016355328695 0.447573202755805 no 1882 0.455405219255225 2714 46368540
SGTC_1190 1486-1332 13 µM -0.112768576729874 0.447236924022235 no 1883 0.455107015764757 2589 4150046
SGTC_306 1672-3436 11.6 µM -0.114060731977982 0.446659357852579 no 1884 0.454594825178578 2692 6797378
SGTC_359 0081-0058 15.9 µM -0.11447273318706 0.446475225720806 no 1885 0.454431530028393 2879 3494159
SGTC_686 1319-0111 510 µM -0.114778508608244 0.446338575618742 no 1886 0.454310342052335 2680 4562600
SGTC_983 1491-0821 12.2 µM -0.115727271671384 0.445914616936085 no 1887 0.453934345898998 2730 46495113
SGTC_3044 9093193 49.47 µM -0.116125159687 0.445736837411934 no 1888 0.453776674578792 2712 25236277
SGTC_816 0325-0417 81.3 µM -0.117326469073869 0.445200149178457 no 1889 0.453300675296598 2678 68101
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.118104539240131 0.444852597739125 no 1890 0.452992413417023 2717 6708760
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.118224260452654 0.444799123953873 no 1891 0.452944983847469 2614 16623 A steroid.
SGTC_2342 7990637 118.86 µM -0.11909766231646 0.444409047238738 no 1892 0.452598991382043 2701 2033102 YER133W GLC7
SGTC_1970 st070122 35.8 µM -0.119657382569195 0.444159094559794 no 1893 0.45237728075103 2748 102928
SGTC_2944 9067346 25.62 µM -0.119828733611662 0.444082579248394 no 1894 0.452309409903529 2727 6473075
SGTC_117 lucigenin 22.078 µM -0.119843427045877 0.444076018120663 no 1895 0.452303590010593 2640 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2921 7974240 10.71 µM -0.120357889768859 0.443846302356659 no 1896 0.452099823970868 2729 2979074 YDR527W RBA50
SGTC_2958 9077254 16.72 µM -0.120750295342869 0.44367109972406 no 1897 0.451944410246821 2762 16457351
SGTC_2931 9014674 55.67 µM -0.122287006472436 0.442985089784157 no 1898 0.451335861048999 2646 2996810
SGTC_2873 9040596 71.43 µM -0.123904812289795 0.442263062685021 no 1899 0.450695321328424 2736 6463863
SGTC_2397 5161689 200 µM -0.12488128481171 0.441827355423246 no 1900 0.450308767463983 2757 2259942
SGTC_1733 st037357 54.9 µM -0.124975074462492 0.441785509675554 no 1901 0.45027164165237 2618 1272339 YGL099W LSG1
SGTC_2094 5332512 191.667 µM -0.12706513631393 0.440853164672889 no 1902 0.449444422470251 2743 755774
SGTC_1112 tnp00069 1.16933 µM -0.128421388481193 0.440248336095737 no 1903 0.448907752869717 2757 145826
SGTC_1188 1403-0014 4.57 µM -0.128487318834663 0.440218937610974 no 1904 0.448881666573154 2644 9614867
SGTC_2701 st077767 14.721 µM -0.128585295276512 0.440175250316102 no 1905 0.448842901187127 2648 5721188
SGTC_1242 0402-0103 60.1 µM -0.129831985627263 0.439619419958895 no 1906 0.448349678107327 2646 432868
SGTC_2666 tannic acid 100 µM -0.130312441207874 0.439405243065685 no 1907 0.448159618670807 2668 16134267 A thiamine antagonist.
SGTC_1562 morin hydrate 59.1 µM -0.130819368772998 0.439179284753879 no 1908 0.447959100303052 2793 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1428 4049-0204 61.7 µM -0.132557450358759 0.438404701727986 no 1909 0.447271692530485 2742 X1428
SGTC_645 0845-0943 5.41 µM -0.132962869820056 0.438224058739523 no 1910 0.4471113726507 2695 1885106
SGTC_3216 9129716 49.47 µM -0.133359051343344 0.438047544338522 no 1911 0.44695471418814 2686 8056934
SGTC_1940 st075990 51.1 µM -0.134513123859353 0.43753343015856 no 1912 0.44649841703065 2903 1084979
SGTC_1298 1079-1278 263 µM -0.135614380491617 0.437042942606519 no 1913 0.446063068248299 2673 2840950
SGTC_1666 st014829 29 µM -0.135759877272736 0.43697814716553 no 1914 0.446005555310314 2614 3858230
SGTC_2877 9040724 71.43 µM -0.136924058524255 0.436459752475563 no 1915 0.445545410991973 2791 6463895
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.137702220159766 0.436113308059339 no 1916 0.445237882342093 2686 75037 A free radical scavenger.
SGTC_835 0312-0010 67.2 µM -0.140699128054268 0.434779518414199 no 1917 0.444053816977784 2648 1626196
SGTC_2142 5622915 118.518 µM -0.141094815020172 0.434603470961887 no 1918 0.443897519845364 2684 5322196
SGTC_1859 st055998 20 µM -0.142926429502731 0.433788725880992 no 1919 0.443174142567218 2655 676301
SGTC_2894 9048625 32.47 µM -0.143244534628614 0.433647253826721 no 1920 0.443048529454681 2762 4092861
SGTC_2354 9060492 162 µM -0.14383131619363 0.433386314633143 no 1921 0.442816836618054 2784 6471895
SGTC_2929 9013348 24.6 µM -0.14444218558202 0.43311469453863 no 1922 0.44257565339182 2762 2995952
SGTC_788 1182-0090 188 µM -0.144584842153864 0.433051267535521 no 1923 0.44251933283861 2870 5715185
SGTC_361 000s-0510 1.45 µM -0.146573563428455 0.432167236011321 no 1924 0.441734310802435 2746 660
SGTC_3007 9078383 71.4286 µM -0.147097783789423 0.431934264583332 no 1925 0.441527419565408 2710 6496995
SGTC_2799 7812892 81.82 µM -0.147199029728196 0.431889272087081 no 1926 0.44148746321039 2787 20205235
SGTC_3188 9110789 49.47 µM -0.148082526869221 0.431496693973448 no 1927 0.441138819472996 2813 849217
SGTC_1803 st050068 52.4 µM -0.148525103545676 0.431300062360872 no 1928 0.440964187948885 2671 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_476 mead acid 10 µM -0.148627319062781 0.431254651626943 no 1929 0.440923857468583 2672 5312531 An omega 9 fatty acid.
SGTC_2730 imipramine 71.33 µM -0.148751674530363 0.431199406122464 no 1930 0.440874792205012 2678 3696 A tricyclic antidepressant.
SGTC_892 0929-0076 29 µM -0.149938620333867 0.430672167725035 no 1931 0.440406520750834 2685 5751038
SGTC_2816 7982706 58.44 µM -0.15029982283898 0.43051174693992 no 1932 0.440264036378169 2780 2981853
SGTC_2869 9037858 32.47 µM -0.151219209393789 0.430103471802193 no 1933 0.439901398818988 2633 27187042
SGTC_2556 citropten 84.59 µM -0.152610947295994 0.429485580286895 no 1934 0.43935254571972 2672 2775 A potential DNA crosslinker.
SGTC_2788 5282734 71.43 µM -0.152718199117912 0.429437970717614 no 1935 0.439310254149711 2804 743706
SGTC_1127 asiatic acid 681.4 nM -0.153143534618407 0.42924917247563 no 1936 0.4391425425552 2675 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_781 4335-2806 94.4 µM -0.15463527569892 0.428587145512455 no 1937 0.438554429247836 2859 845254
SGTC_1871 st057448 67.3 µM -0.155714778664179 0.428108192869481 no 1938 0.438128923791317 2838 691747
SGTC_20 0481-0013 4.944 µM -0.156630262987086 0.427702094780922 no 1939 0.437768125250282 2680 182045
SGTC_2210 7115885 190.385 µM -0.157772202992413 0.427195650993307 no 1940 0.437318151542425 2688 2927039
SGTC_2809 7964133 12.99 µM -0.157895919638122 0.427140790564216 no 1941 0.4372694066946 2731 1253665
SGTC_867 0518-0118 155 µM -0.158092745189588 0.4270535139103 no 1942 0.437191858611462 2710 6848158
SGTC_3304 9125678 46.087 µM -0.158158313596462 0.427024440270748 no 1943 0.437166025589295 2718 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2368 9071271 200 µM -0.158174615460779 0.427017211934484 no 1944 0.437159602927586 2712 27209959
SGTC_2766 oltipraz 83.91 µM -0.159653564081164 0.42636154024069 no 1945 0.436576991035347 2802 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3208 9114115 49.47 µM -0.159952650056113 0.426228969230953 no 1946 0.436459186824024 2770 650895
SGTC_2671 danthron 100 µM -0.160313645478245 0.426068967724296 no 1947 0.436317005179607 2723 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_3030 9087619 49.47 µM -0.160594063009235 0.425944688596418 no 1948 0.436206565617894 2712 25236973
SGTC_1011 4112-3381 17.4 µM -0.161801898252439 0.425409468515839 no 1949 0.435730929076423 2869 2877139
SGTC_48 0382-0018 55 µM -0.162226435977195 0.425221378498451 no 1950 0.435563771316818 2938 762596
SGTC_1040 k898-0338 155 µM -0.163702085225555 0.424567729697904 no 1951 0.434982837961357 2796 20969351
SGTC_2690 usnic acid 100 µM -0.164227945468426 0.424334846378568 no 1952 0.434775851234049 2865 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2191 5911152 200 µM -0.164390672629943 0.424262786112061 no 1953 0.434711802924596 2724 2875902
SGTC_3293 9120939 62.045 µM -0.165002253446534 0.423991983197202 no 1954 0.434471104187786 2841 934087
SGTC_616 4092-0450 108 µM -0.165392207173662 0.42381933364751 no 1955 0.434317643491824 2763 787165
SGTC_1635 st007035 42.4 µM -0.16850083124802 0.422443535538639 no 1956 0.433094644889711 2687 3716403
SGTC_1447 4239-0816 81.9 µM -0.16868099975023 0.422363826364572 no 1957 0.433023782306531 2713 1341554
SGTC_1687 st020778 55.3625 µM -0.168848923869801 0.422289537146574 no 1958 0.432957737535062 2721 4259299
SGTC_701 4424-0219 185 µM -0.169266521010859 0.422104805188288 no 1959 0.432793504166827 2808 2911779
SGTC_1462 k081-0014 26.5 µM -0.169473858109066 0.422013092082589 no 1960 0.432711966564103 2733 3270634
SGTC_331 k048-0133 24.5 µM -0.169759864493264 0.421886587492927 no 1961 0.432599496098792 2709 6813582
SGTC_890 0929-0006 47.2 µM -0.170078920195629 0.421745474242835 no 1962 0.432474035611609 2717 1378169
SGTC_1189 1431-2119 7.28 µM -0.170476410394316 0.421569684724188 no 1963 0.432317742292084 2708 3107275
SGTC_2457 5731572 11.68 µM -0.170476747748041 0.421569535536579 no 1964 0.432317609648946 2860 2865357
SGTC_1645 Cervolide 78 µM -0.170811517582259 0.421421496151244 no 1965 0.432185986226403 2790 23173 A fragrance.
SGTC_1776 st049249 45.9 µM -0.171389953397514 0.421165730824031 no 1966 0.431958576963919 2747 1822314
SGTC_2846 9008642 19.48 µM -0.171560711948484 0.421090233353408 no 1967 0.431891448366324 2830 2992898
SGTC_176 1486-1328 72.834 µM -0.173024461403114 0.420443185189747 no 1968 0.431316100090347 2788 22310231
SGTC_3075 9116269 49.47 µM -0.174021579483135 0.420002533654729 no 1969 0.430924251504108 2890 17015205 YNL244C SUI1
SGTC_1196 1588-0294 184 µM -0.175150373914632 0.419503812057632 no 1970 0.430480738664884 2761 6144269
SGTC_82 0054-0107 293.755 µM -0.17949814062884 0.417584105618237 no 1971 0.428773288592145 2799 3104697
SGTC_1172 0370-0043 85 µM -0.180837370326546 0.416993177365496 no 1972 0.428247614691554 2875 376585
SGTC_1643 st009866 20.2 µM -0.181162729357841 0.416849642613206 no 1973 0.428119924080385 2799 3156273 YOR207C RET1
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.182284058768298 0.416355044169224 no 1974 0.42767990417994 2727 2724 A muscle relaxant with antifungal properties.
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.185532144071854 0.414923121522214 no 1975 0.426405835286007 2737 4174840
SGTC_3056 9094900 49.47 µM -0.185750152701208 0.414827052374596 no 1976 0.426320348245358 2775 25236784
SGTC_1337 1486-1011 40.3 µM -0.185756228183246 0.41482437518478 no 1977 0.426317965935188 2732 X1337
SGTC_3322 9139058 2.11 µM -0.185764631821486 0.414820672088472 no 1978 0.426314670715845 2905 4908926 YPR165W RHO1
SGTC_1725 st036284 20.55 µM -0.187261707722215 0.414161100772021 no 1979 0.425727722334 2987 707914
SGTC_1401 3807-4679 7.6 µM -0.1876011976483 0.414011564253284 no 1980 0.425594643663457 2727 3291456
SGTC_514 4466-0038 2.65 nM -0.187827315684464 0.413911972030809 no 1981 0.425506011014288 2792 5722064
SGTC_1737 st035557 69.7 µM -0.190692133280186 0.412650663213403 no 1982 0.424383401164977 2678 5716916
SGTC_307 1501-1223 22.3 µM -0.191185620280497 0.412433483658113 no 1983 0.424190084586824 2818 2830329
SGTC_2086 5274770 176.623 µM -0.19338012743387 0.41146802474649 no 1984 0.423330638849002 2817 689278
SGTC_1610 st001799 48.1 µM -0.193710081957089 0.411322909632754 no 1985 0.423201448557521 2728 621897
SGTC_1868 st057644 42.7 µM -0.194746013536889 0.410867382349385 no 1986 0.422795893948841 2741 688665
SGTC_1458 k015-0034 6.33 µM -0.195062736921898 0.410728134425548 no 1987 0.422671916907811 2804 3598957
SGTC_1758 st042942 75.2445 µM -0.196807122010164 0.409961414906697 no 1988 0.421989238781342 2729 669317
SGTC_2153 5569715 200 µM -0.198225176672645 0.409338382688351 no 1989 0.421434445084633 2763 2054701
SGTC_1741 st038134 10.228 µM -0.200618652611697 0.408287312363368 no 1990 0.420498385958215 2953 1272587
SGTC_1114 scopoletin 1.73284 µM -0.202426069171161 0.407494040583838 no 1991 0.41979182498988 2855 5280460 A coumarin with genotoxic properties.
SGTC_2343 7990716 14.84 µM -0.202883325526919 0.407293411588608 no 1992 0.419613113774274 2775 6456862
SGTC_1505 k297-0037 20.6 µM -0.203898295454921 0.406848163259577 no 1993 0.419216488564737 2780 4089396
SGTC_2598 perillyl alcohol 100 µM -0.204059306247276 0.406777541883567 no 1994 0.419153577051571 2928 10819 An apoptosis inducer.
SGTC_997 3996-0078 137 µM -0.20463415480597 0.406525430760557 no 1995 0.418928984182938 2826 735687
SGTC_2726 cimetidine 79.27 µM -0.205375448074975 0.40620037924645 no 1996 0.41863940050964 2766 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.20538860237056 0.406194611769978 no 1997 0.418634262226808 2753 2333 A French combination drug.
SGTC_3145 9085516 49.47 µM -0.206049104287931 0.405905042127204 no 1998 0.41837627725022 2846 25236195
SGTC_943 3253-1379 105 µM -0.20840230340691 0.404873799093715 no 1999 0.417457428977417 2932 668464
SGTC_2453 5731132 22.18 µM -0.208471567039981 0.404843455643343 no 2000 0.417430390566495 2910 1362040
SGTC_1831 st055328 12 µM -0.209690893338522 0.404309379320473 no 2001 0.416954466794739 2932 1103068
SGTC_590 k048-0076 22.4 µM -0.209841388794285 0.404243473243344 no 2002 0.416895734282871 2890 6832814
SGTC_2905 7799065 20.05 µM -0.210435090877778 0.403983501383062 no 2003 0.41666405359843 2936 1296806
SGTC_1362 1611-0397 101 µM -0.211440602213642 0.403543302162138 no 2004 0.416271738428374 2800 27816
SGTC_194 1486-1323 56.904 µM -0.211505977265372 0.403514686075168 no 2005 0.416246234265108 2815 5178754
SGTC_2138 5575593 77.673 µM -0.212256339620166 0.403186273121835 no 2006 0.41595352763022 2785 762213
SGTC_3091 9116372 49.47 µM -0.212655163666669 0.40301174658502 no 2007 0.415797970498503 2940 17169793
SGTC_165 k038-0023 64.381 µM -0.213420410537237 0.402676926507774 no 2008 0.415499530953646 2801 46368543
SGTC_1408 3909-7976 48.8 µM -0.21404102906019 0.402405438374222 no 2009 0.415257530974592 2819 24152374
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.214441049039956 0.402230475498133 no 2010 0.415101566797898 2820 2374 Ca(2+)-ATPase inhibitor.
SGTC_2315 7733312 200 µM -0.215410476035909 0.401806543654767 no 2011 0.414723651512094 2812 726316
SGTC_2271 7849410 118.62 µM -0.216088812359988 0.401509974850863 no 2012 0.414459260077402 2763 972430
SGTC_1159 4092-0538 61.2 µM -0.216262676484288 0.401433970539447 no 2013 0.414391500244204 2797 717301
SGTC_153 4077-0274 519.67 µM -0.217209795546849 0.401020005125046 no 2014 0.414022425587783 3060 3121976
SGTC_1028 k015-0029 4.8 µM -0.21745442660395 0.400913100176691 no 2015 0.413927109746017 2778 4588309
SGTC_288 1315-0019 35.1 µM -0.219628054269343 0.399963541166395 no 2016 0.413080420340075 2862 6811474
SGTC_840 0245-0196 390 µM -0.220726571287792 0.399483873604001 no 2017 0.412652670397481 2926 3827528
SGTC_1982 st072467 71.9 µM -0.221313852271896 0.399227499480975 no 2018 0.412424032419693 2751 3163533
SGTC_1884 5633444 25 µM -0.221981919717746 0.398935911334782 no 2019 0.412163979098445 2939 5724239
SGTC_2256 7954252 200 µM -0.22220419520501 0.398838908329156 no 2020 0.412077464224877 2870 2972920
SGTC_143 4032-1194 15.74 µM -0.224514652081678 0.397830975408667 no 2021 0.411178433594529 2732 1806963
SGTC_2700 st077718 96.8 µM -0.224721844542138 0.397740621248922 no 2022 0.411097834863258 2852 904970
SGTC_2451 5856223 45.7 µM -0.224872258616116 0.39767503090213 no 2023 0.411039325511953 2838 2179896
SGTC_2104 5389443 200 µM -0.226319788683136 0.397043961502873 no 2024 0.410476354250247 2989 2244536
SGTC_2760 etidronate 98.04 µM -0.227121134546603 0.396694720217662 no 2025 0.410164775224262 2836 3305 A chelator and antioxidant.
SGTC_13 0199-0087 65 µM -0.227447227577587 0.396552626570853 no 2026 0.410038000064119 2786 4589825
SGTC_1615 st002656 86.5 µM -0.227501216349788 0.39652910251872 no 2027 0.410017011760573 2784 1584458
SGTC_1072 oxiconazole 14.9 nM -0.227501794217754 0.396528850731439 no 2028 0.410016787113993 2812 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_672 1441-0018 53.7 µM -0.227891094154087 0.396359235682989 no 2029 0.409865453204508 2799 251141
SGTC_934 2950-0684 338 µM -0.229257697793454 0.395763972254578 no 2030 0.409334315078767 3023 1121253
SGTC_3338 9144300 39.5675 µM -0.229704730908536 0.395569306839455 no 2031 0.409160609234252 2876 4901274
SGTC_2232 chlorophetanol 41.5365 µM -0.233497595292293 0.393918715720686 no 2032 0.407687518317294 2838 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2287 7945887 168.79 µM -0.234166005903908 0.393628031083902 no 2033 0.407428052370841 2921 1245853
SGTC_2409 alverine citrate 63.97 µM -0.234578464206324 0.393448686933827 no 2034 0.407267963131853 3086 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_549 1661-1316 519 µM -0.234680501506908 0.393404322800837 no 2035 0.40722836133835 2947 2857282
SGTC_42 0133-0086 60.653 µM -0.235409567114213 0.393087377420349 no 2036 0.40694543061155 2769 162923 Model of phenazepam hydroxylation.
SGTC_2561 acetosyringone 100 µM -0.237865726763211 0.392020138140305 no 2037 0.405992619354808 2801 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_635 k038-0028 24.7 µM -0.238100702014011 0.391918080191725 no 2038 0.405901495132832 2873 4035102
SGTC_2090 5301565 104.445 µM -0.239806820406234 0.391177276888856 no 2039 0.405240009657838 2842 2056344
SGTC_332 4112-0506 40.9 µM -0.239977175962315 0.391103329462456 no 2040 0.405173975302665 2827 2790355
SGTC_1981 st071826 47 µM -0.240503254674417 0.390874995660338 no 2041 0.404970070216899 2930 11838600
SGTC_11 0438-0307 1.3 µM -0.241616640183238 0.390391877384315 no 2042 0.404538613529165 2939 4011476
SGTC_2378 9074213 121.43 µM -0.242402036245592 0.390051181437582 no 2043 0.404234328362096 2836 657714
SGTC_1097 itavastatin 7.23 µM -0.242549200882383 0.389987352464873 no 2044 0.404177318960678 2858 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2541 muurolladie-3-one 83.07 µM -0.243018803858975 0.389783693786112 no 2045 0.403995415332868 3006 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2265 7929201 200 µM -0.244630514383862 0.389084953285651 no 2046 0.403371267367275 2812 1265108
SGTC_3185 9108267 49.47 µM -0.245436962440754 0.38873546048269 no 2047 0.40305905607896 2922 4910486
SGTC_2033 5192550 145 µM -0.245660028297961 0.388638805650219 no 2048 0.402972708437999 2872 182073
SGTC_121 0557-0495 61.343 µM -0.246135112940127 0.38843297361411 no 2049 0.402788821402322 2837 3104427
SGTC_2580 diallyl disulphide 81.36 µM -0.25060939397519 0.386496020391738 no 2050 0.401058059059153 2861 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_737 1950-0117 57.9 µM -0.251520355911874 0.38610200197421 no 2051 0.400705913094074 2981 5393513
SGTC_1783 st039459 87.517 µM -0.253441098810126 0.385271608276564 no 2052 0.399963685905482 3075 729761
SGTC_289 k017-0060 526 µM -0.254140367366136 0.384969424238539 no 2053 0.399693559113587 2858 5512909
SGTC_2949 9072542 2.23 µM -0.256188746880074 0.384084633923646 no 2054 0.398902548720958 2962 16457352
SGTC_2149 5554786 194.827 µM -0.257156601750536 0.383666782172313 no 2055 0.398528942204593 2867 745063 YPR165W RHO1
SGTC_1523 st012844 44.7 µM -0.257676907013445 0.383442206769091 no 2056 0.398328134963792 2972 4274103
SGTC_2145 5634607 200 µM -0.257969089938572 0.38331611123825 no 2057 0.398215381333425 2852 308662
SGTC_1960 st011366 51.8 µM -0.258639699056098 0.383026747475931 no 2058 0.397956624876333 2832 3972846
SGTC_1497 4476-2978 41.3 µM -0.259186802951563 0.38279072379907 no 2059 0.397745556499746 2947 1528379
SGTC_2916 7875993 68.79 µM -0.260084294638855 0.382403635159321 no 2060 0.397399376114223 2891 1299250
SGTC_1454 4239-0054 42.6 µM -0.260508401714188 0.382220758402797 no 2061 0.397235817679584 3058 1340767
SGTC_1504 k297-0033 30 µM -0.260965531067411 0.38202367172008 no 2062 0.397059544318983 2827 4388117
SGTC_1668 st014914 51.6 µM -0.261568481026855 0.381763762720229 no 2063 0.396827073330681 2913 2839556
SGTC_1105 epirubicin 18.1 µM -0.26337157808093 0.380986833947198 no 2064 0.396132097455199 2865 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.266141032974105 0.379794450246368 no 2065 0.395065297223703 2865 688803
SGTC_2868 9035608 32.47 µM -0.267019278841495 0.379416561059985 no 2066 0.394727158737925 2821 6462614
SGTC_923 1900-2434 73.3 µM -0.268994759260514 0.378566978215903 no 2067 0.393966857794851 2843 5910570
SGTC_2472 5377652 49.4 µM -0.269461000025064 0.378366550291704 no 2068 0.393787475044048 2930 1610903
SGTC_256 clotrimazole 625 nM -0.269866290649548 0.37819235024071 no 2069 0.393631560724809 2947 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.270428606702962 0.377950699292337 no 2070 0.393415267351262 2926 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_502 l-744,832 89.3 µM -0.272039571735173 0.377258664242132 no 2071 0.39279579623337 3001 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1848 st056003 16.4 µM -0.273084516160842 0.376809989674823 no 2072 0.39239412441918 2913 146492
SGTC_118 0083-0097 135.343 µM -0.275005904974841 0.375985424968354 no 2073 0.391655850824817 2919 5207356
SGTC_3174 9107204 49.47 µM -0.275065027482898 0.375960061477788 no 2074 0.391633139790225 3014 3938802
SGTC_2015 5119600 184 µM -0.275831768177096 0.375631179139775 no 2075 0.391338641204596 3078 2828786
SGTC_1784 st039334 36.3 µM -0.276994769401963 0.375132499091457 no 2076 0.390892061241539 3135 3496984
SGTC_1501 4491-0275 38.4 µM -0.277798551519608 0.374787969475681 no 2077 0.3905835015782 2987 5104718
SGTC_2487 5918373 44.05 µM -0.277970079304304 0.374714459490393 no 2078 0.390517663597726 2951 2876279
SGTC_486 niguldipine 82 µM -0.27820142029302 0.374615323155869 no 2079 0.39042887232311 2883 1236 A calcium channel blocker.
SGTC_2714 st079313 56.9 µM -0.278714602397615 0.374395439304284 no 2080 0.390231927660951 2896 2939799
SGTC_1091 telmisartan 47.6 µM -0.280528562486044 0.373618537094374 no 2081 0.389536007561438 2999 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2224 6650123 117.647 µM -0.280852408506781 0.373479890770561 no 2082 0.389411802235984 2914 2908370
SGTC_2455 5377712 9.75 µM -0.282232143071877 0.372889376697611 no 2083 0.388882756554389 2985 2243908
SGTC_2468 5987765 72.9 µM -0.282257580033859 0.372878492703653 no 2084 0.388873004931725 2956 26772094
SGTC_2681 menadione 3.18 µM -0.282309557296795 0.372856252933433 no 2085 0.388853078923351 2988 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_98 0074-0023 107.663 µM -0.283485474357909 0.372353220820612 no 2086 0.388402357477827 2984 3563821
SGTC_1149 3909-7961 23.3 µM -0.283515382722581 0.372340429498715 no 2087 0.388390895750615 2929 735261
SGTC_290 2043-6722 48.1 µM -0.284830270674125 0.371778212659506 no 2088 0.387887089870243 2993 773758 YLR208W SEC13
SGTC_664 1222-0054 14.9 µM -0.28527325479026 0.371588864001597 no 2089 0.387717400739604 2922 6813991
SGTC_2029 5175081 200 µM -0.28633169635371 0.371136570732973 no 2090 0.387312041867579 2889 1380876
SGTC_2964 9083345 53.42 µM -0.286509150409236 0.371060758462484 no 2091 0.387244093041145 2975 17741579
SGTC_1280 0880-0253 10.1 µM -0.289475028653022 0.369794412945455 no 2092 0.386108943267838 2916 6836607
SGTC_690 glyoxal 20.3 µM -0.289943203351567 0.369594644258173 no 2093 0.385929844525624 2944 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_213 1246-0773 967 nM -0.290361004181746 0.369416399661095 no 2094 0.385770036672653 2953 6251622
SGTC_2177 5811945 192 µM -0.29123715131926 0.369042703898062 no 2095 0.385434975396919 3080 5343475
SGTC_497 capsazepine 133 µM -0.292188806443242 0.368636942548884 no 2096 0.385071134780167 2928 2733484 A calcium channel blocker.
SGTC_236 1509-0011 5.31 µM -0.292306756057608 0.368586662045905 no 2097 0.385026046848516 3027 3107280
SGTC_192 3455-0609 60.9 µM -0.292944076164982 0.368315019085119 no 2098 0.384782449004097 3053 3769639
SGTC_3148 9097893 49.47 µM -0.293106679767036 0.368245723591489 no 2099 0.384720305587827 2933 17174100
SGTC_2972 9093619 59.92 µM -0.293281752029934 0.368171119218713 no 2100 0.38465340024271 2906 25236256
SGTC_2940 9060638 45.86 µM -0.294085484917506 0.367828684551723 no 2101 0.384346291040178 3014 4027022
SGTC_163 TUB2.036 7.546 µM -0.294619851982114 0.367601072732844 no 2102 0.384142147637959 3044 15992207 YJR013W GPI14
SGTC_888 0916-0002 6.97 µM -0.295482997181618 0.367233517235611 no 2103 0.383812469547956 3089 2802138 YIL048W NEO1
SGTC_3029 9088683 49.47 µM -0.297184022259228 0.36650952135771 no 2104 0.383163009762863 3072 25236615
SGTC_706 4262-0057 46.9 µM -0.297272988365677 0.366471668354537 no 2105 0.38312905108104 2943 883298
SGTC_340 k038-0059 454 µM -0.297718016273615 0.366282338866362 no 2106 0.382959195820299 2933 23733424
SGTC_1748 st037455 53.6035 µM -0.299743289811944 0.365421132676296 no 2107 0.382186487717923 3113 580690
SGTC_1518 st038567 90.8 µM -0.300588354180759 0.365061986562451 no 2108 0.381864206510327 2955 77966
SGTC_3103 9120822 49.47 µM -0.300686975831761 0.365020080794417 no 2109 0.381826600616632 3159 17141819
SGTC_3059 1327-0034 3 µM -0.301012155929219 0.364881918484181 no 2110 0.381702612539724 2940 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_842 0271-0008 11.1 µM -0.301548144811559 0.364654226169184 no 2111 0.381498271571723 3056 1221709
SGTC_433 pimozide 108 µM -0.301815170235797 0.364540809467341 no 2112 0.381396482837869 2885 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2317 5986382 200 µM -0.302630108920089 0.364194744772472 no 2113 0.381085883103303 3010 877883
SGTC_555 4296-0685 37 µM -0.302899689637765 0.364080291347887 no 2114 0.380983153941658 2982 2908540 YHR072W ERG7
SGTC_2897 9048598 12.99 µM -0.302920203815916 0.364071582326731 no 2115 0.380975336944286 2946 6467404
SGTC_3347 9188721 44.724 µM -0.304117881232006 0.363563246154945 no 2116 0.38051904219457 3007 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1834 st055981 52.8 µM -0.304468944481081 0.363414288104348 no 2117 0.380385324526084 3093 471719 YDL150W RPC53
SGTC_1422 4031-0024 15.5 µM -0.304833889623312 0.363259461781881 no 2118 0.380246334487482 3002 782427
SGTC_1901 st060216 58.6 µM -0.305064804148243 0.363161508878651 no 2119 0.380158398245161 2920 688792
SGTC_2485 5633444 17.78 µM -0.305269960337042 0.363074490053046 no 2120 0.380080276418755 3033 5724239
SGTC_2065 5221596 34.26 µM -0.305980604439339 0.362773118696269 no 2121 0.379809706705185 3072 788581
SGTC_1710 st031758 61.5 µM -0.306418717333022 0.362587365246473 no 2122 0.379642929475374 3102 5394341
SGTC_2026 5148700 152 µM -0.306831508637939 0.362412377367218 no 2123 0.379485811944327 2928 79838
SGTC_488 nitrendipine 139 µM -0.309250227854856 0.361387627890428 no 2124 0.37856559441432 2947 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1363 1636-0063 10.4 µM -0.310357303632708 0.360918919220978 no 2125 0.378144629446789 2952 6072185
SGTC_1694 st024011 44.9 µM -0.311164332492609 0.360577374571433 no 2126 0.377837848265522 3037 2787533
SGTC_2233 sulbentine 40.3845 µM -0.31193892968174 0.360249659983841 no 2127 0.377543467993717 3000 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1554 st069299 38.7 µM -0.312544995835192 0.35999331864382 no 2128 0.377313186355097 3031 24207999
SGTC_2872 9044037 25.97 µM -0.312679650030854 0.359936373936995 no 2129 0.377262028900975 2936 6465195
SGTC_1719 st032227 49.2 µM -0.313649939301436 0.359526134556625 no 2130 0.376893462981628 2959 3125804
SGTC_2110 5483698 200 µM -0.314226587656473 0.359282403632929 no 2131 0.376674475299616 3007 2848765 YHR062C RPP1
SGTC_2675 theaflavin digallate 100 µM -0.314562342048216 0.359140517292782 no 2132 0.376546987657093 2995 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_792 4534-1957 155 µM -0.315409485924251 0.358782609416744 no 2133 0.376225382709166 2987 1717904
SGTC_2662 daunorubicin 22.37 µM -0.315618196097455 0.358694450953695 no 2134 0.376146162333701 2952 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1806 st050005 60.3 µM -0.319466449407866 0.357070315401532 no 2135 0.374686414493889 2973 5194765
SGTC_1318 1280-3875 124 µM -0.31962041702146 0.357005387784669 no 2136 0.374628047547565 3029 373245
SGTC_1250 0485-0349 40.2 µM -0.319987427493188 0.356850637426058 no 2137 0.374488930650138 2988 6842794 YDL195W SEC31
SGTC_626 0214-0009 33 µM -0.321009219492118 0.356419921877671 no 2138 0.374101702108119 3089 3437874
SGTC_1789 tunicamycin 25 nM -0.321534658526931 0.356198505025429 no 2139 0.373902625882042 3089 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1822 st052468 42 µM -0.321803235984361 0.356085346816265 no 2140 0.373800881321619 3029 2873678
SGTC_868 0527-0199 213 µM -0.321833698972508 0.356072512819268 no 2141 0.373789341655281 2993 2849450
SGTC_2777 climbazole 1.536 µM -0.321918975280613 0.356036586945584 no 2142 0.373757038789623 3054 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_369 0957-0393 4.5 µM -0.321988227903201 0.356007412596589 no 2143 0.373730806386121 3025 6997992
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.322081625673039 0.355968067853259 no 2144 0.373695428898079 2988 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2037 5169046 200 µM -0.323975980656696 0.355170383480174 no 2145 0.372978109496672 3077 5718022
SGTC_1747 st037496 66.6 µM -0.327866895313133 0.353533970288225 no 2146 0.37150615255056 2997 723305
SGTC_1129 3453-1384 223 µM -0.328660664113378 0.353200463680035 no 2147 0.371206094750157 3184 1084452
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.331581902519493 0.351974060682691 no 2148 0.370102493432656 3209 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_97 0535-0701 19.132 µM -0.33192782542228 0.351828935921466 no 2149 0.369971879388934 3019 2832013 YGL099W LSG1
SGTC_327 1273-0057 3.96 µM -0.332678877333725 0.35151392204132 no 2150 0.369688347823273 3036 3108138
SGTC_1034 k072-0165 12.7 µM -0.332718204229679 0.351497429959183 no 2151 0.369673503374618 3148 5835461
SGTC_203 k066-0004 30.888 µM -0.333759662314482 0.351060787095928 no 2152 0.3692804622111 3071 6795412
SGTC_1120 ficusin 1.78878 µM -0.333982814463508 0.35096725363309 no 2153 0.369196263443507 3130 6199 A DNA cross-linker.
SGTC_2658 polymyxin b sulfate 77.05 µM -0.335303659994781 0.350413810794534 no 2154 0.368698016552803 3014 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2630 antimycin a 100 µM -0.335816289294399 0.35019910123365 no 2155 0.368504702867896 2937 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_743 1275-0778 158 µM -0.33660974135415 0.349866866329915 no 2156 0.368205555904312 3086 2849257 YMR203W TOM40
SGTC_599 1935-0052 86.5 µM -0.338270857445616 0.34917169479391 no 2157 0.367579541496336 2994 9557311
SGTC_1892 st058411 7.36 µM -0.338480817268304 0.349083863266668 no 2158 0.367500440256147 3106 3934738
SGTC_2206 7254556 146.969 µM -0.338747113462455 0.348972476432906 no 2159 0.367400122675871 3044 4398905
SGTC_107 0358-0022 2.6945 µM -0.339451977396269 0.348677707551581 no 2160 0.367134634055106 3085 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1423 4048-0112 5.59 µM -0.343057310298856 0.347171415619949 no 2161 0.365777672929074 3094 X1423
SGTC_92 0063-0024 660.874 µM -0.343123454583107 0.347143803287049 no 2162 0.365752793422329 3009 3594437
SGTC_1313 1220-0047 237 µM -0.343935047526915 0.34680506498973 no 2163 0.365447566904255 3055 3528706
SGTC_268 camptothecin 39.6153 µM -0.343938578047632 0.346803591707216 no 2164 0.365446239320489 3101 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2313 7726885 200 µM -0.344107008072345 0.346733308729953 no 2165 0.36538290635315 3099 726423
SGTC_1622 st003707 19.4 µM -0.346620613741628 0.345685051821738 no 2166 0.36443817871067 3144 10140899
SGTC_3189 9110682 49.47 µM -0.346624634946616 0.345683375790851 no 2167 0.364436668016212 3128 17122418
SGTC_296 1222-0039 74.9 µM -0.347441709180898 0.345342883529974 no 2168 0.364129751620497 3049 5984176
SGTC_1927 st060202 13.8 µM -0.347963110352264 0.345125669922616 no 2169 0.363933943985727 3102 688887
SGTC_2516 gossypol 71.55 µM -0.348920509790792 0.344726954093855 no 2170 0.36357449355769 3162 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1317 1273-0028 910 nM -0.349620596583136 0.34443550705198 no 2171 0.363311725743722 3024 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_960 1222-0186 7.7 µM -0.350454693558601 0.344088391947244 no 2172 0.362998743037286 3137 3126296
SGTC_2425 5628681 7.85 µM -0.351753336465705 0.343548214408175 no 2173 0.362511628409321 3105 5714958
SGTC_2881 9058953 51.95 µM -0.352683131638885 0.343161657178792 no 2174 0.362163003386628 2984 17122249
SGTC_1019 4262-0212 3.4 µM -0.35282794699955 0.343101465744897 no 2175 0.362108715409484 3115 4677213
SGTC_3032 9089427 49.47 µM -0.354562708637803 0.342380734745275 no 2176 0.361458608735477 3121 17173707
SGTC_457 grayanotoxin iii 135 µM -0.355237551341522 0.3421005167318 no 2177 0.361205817490044 3112 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2998 9066762 71.4286 µM -0.355295084446965 0.342076631017755 no 2178 0.361184268802382 3223 4945196
SGTC_195 4234-0266 16.654 µM -0.356497719824492 0.341577484066037 no 2179 0.360733929697516 3065 2303354
SGTC_533 1222-0222 6.71 µM -0.356800668551851 0.341451790555671 no 2180 0.360620517866687 3192 3982874
SGTC_2105 5350118 200 µM -0.357408207428854 0.341199775507597 no 2181 0.360393116672725 3054 2133313
SGTC_887 0885-0007 9.62 µM -0.358017598279881 0.340947063372522 no 2182 0.360165071885189 3151 5719458
SGTC_1616 st002734 56.1 µM -0.35879872025277 0.340623239323993 no 2183 0.35987283504991 3032 4026101
SGTC_2380 9035439 200 µM -0.36271922394624 0.338999722685475 no 2184 0.358407318856997 3185 6462575
SGTC_918 glabranin 770.725 nM -0.36311755681924 0.338834935965232 no 2185 0.358258535003947 3077 124049 Also referred to as licorice root.
SGTC_814 3342-0569 96 µM -0.365301340936791 0.337932072852298 no 2186 0.357443238775388 3087 4346283
SGTC_710 3448-4187 58 µM -0.365796562659402 0.337727457913348 no 2187 0.357258442495855 3088 3946412
SGTC_3006 9075424 71.4286 µM -0.365826764894845 0.337714980551668 no 2188 0.357247173352399 3073 7465181
SGTC_483 fpl-64176 144 µM -0.366891149527231 0.337275368418715 no 2189 0.356850106728758 3092 3423
SGTC_1016 4226-1401 38 µM -0.36752765819155 0.337012583679918 no 2190 0.356612732455062 3122 2901613
SGTC_69 0096-0274 206.684 µM -0.368354181665661 0.336671469377967 no 2191 0.356304578503573 3326 6741392
SGTC_1467 k284-1082 293 µM -0.369828955946171 0.336063149483243 no 2192 0.355754969390344 3143 3334705
SGTC_2841 9004761 38.96 µM -0.373643504360666 0.334491705162766 no 2193 0.354334781303191 3081 2991039
SGTC_2111 5486399 200 µM -0.373731796409933 0.334455366482409 no 2194 0.354301933321669 3067 689674
SGTC_1106 tegaserod maleate 11.7 µM -0.373809850928815 0.334423242591358 no 2195 0.35427289499128 3105 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_47 0149-0135 24.25 µM -0.374648703236726 0.334078083541048 no 2196 0.353960873420304 3054 5239155
SGTC_2986 9022445 71.43 µM -0.374729548495077 0.334044825887923 no 2197 0.353930807195781 3212 6459286
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.377046183212304 0.333092376734368 no 2198 0.353069642052915 3090 688664
SGTC_2695 st077686 51.995 µM -0.378707221871617 0.332410127581025 no 2199 0.352452644935997 3096 2876092
SGTC_2887 9044784 58.44 µM -0.379297249509696 0.332167915152119 no 2200 0.35223357095467 3071 6465546
SGTC_348 k064-0012 10.7 µM -0.379357258156617 0.332143284909246 no 2201 0.35221129282308 3018 5066323
SGTC_3102 9121669 49.47 µM -0.379615984948625 0.332037100121808 no 2202 0.35211524664819 3088 41905072
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.38094952802863 0.331490011033152 no 2203 0.351620350190137 3054 5355888
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.382169698314733 0.330989748141841 no 2204 0.351167748145217 3047 91467 include heat shock
SGTC_2718 lomofungin 53.02 µM -0.38277176404412 0.33074301567603 no 2205 0.350944499500693 3220 5351222 A RNA synthesis inhibitor.
SGTC_3222 9128301 49.47 µM -0.385061788925571 0.329805213322515 no 2206 0.350095818655946 3060 4911358
SGTC_124 0136-0217 7.121 µM -0.385306366657653 0.329705117845188 no 2207 0.350005222547517 3256 3976905
SGTC_1955 wogonin 32.4 µM -0.385447911074982 0.329647195182574 no 2208 0.349952795781241 3281 5281703 A flavanone.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.385747405940559 0.329524649668804 no 2209 0.349841875033656 3183 7104
SGTC_2140 5586273 200 µM -0.386138550136591 0.329364631196653 no 2210 0.349697030389268 3149 854421
SGTC_87 0100-0052 35.5 µM -0.38626505377174 0.329312884798522 no 2211 0.349650189496691 3206 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1342 1486-1464 234 µM -0.387718820149495 0.328718455543404 no 2212 0.349112063362999 3082 3253938
SGTC_1732 st034308 51.822 µM -0.389156406472249 0.328131067967004 no 2213 0.348580224621749 2981 830119
SGTC_1459 k035-0031 35.7 µM -0.389491352134307 0.327994272502002 no 2214 0.348456353307652 3054 3877128 YMR208W ERG12
SGTC_1094 duloxetine 25.4 µM -0.390233121186083 0.32769140806562 no 2215 0.348182086026573 3066 60834 A selective serotonin reuptake inhibitor.
SGTC_1241 0364-0022 50.8 µM -0.391695662328989 0.327094584397996 no 2216 0.347641547710784 3116 4563895
SGTC_2152 5568786 200 µM -0.392411469158339 0.32680264386241 no 2217 0.347377106545604 3144 5399883
SGTC_3158 9100007 49.47 µM -0.392762465928264 0.326659529176354 no 2218 0.347247464621529 3092 19297233
SGTC_714 4296-0578 26.1 µM -0.392968308930366 0.326575611045273 no 2219 0.347171444078142 3081 1589775
SGTC_1463 k081-0032 34.1 µM -0.393273451485905 0.326451226591403 no 2220 0.34705876221103 3154 977755
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.393754426985796 0.326255206998199 no 2221 0.346881176888897 3060 6312947
SGTC_2148 5546263 113.568 µM -0.394990276065505 0.325751761924518 no 2222 0.346425032152287 3083 792097
SGTC_438 sphingosine 6.67 µM -0.39710998826418 0.32488899942488 no 2223 0.345643177342198 3071 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1596 piperlongumine 63 µM -0.398955278624356 0.324138695476594 no 2224 0.344963078407607 3240 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2228 7354201 200 µM -0.399151819880491 0.324058822859591 no 2225 0.34489067075723 3132 753451
SGTC_71 0417-1750 47.813 µM -0.399395501716335 0.323959803975801 no 2226 0.344800903960543 3276 6811472
SGTC_3015 9080845 49.47 µM -0.399524434740828 0.323907417730189 no 2227 0.344753411526614 3234 5296973
SGTC_128 0906-2981 13.371 µM -0.400056212263026 0.323691390263905 no 2228 0.344557557324427 3266 6740226
SGTC_689 0833-0039 98 µM -0.4001706192323 0.32364492173234 no 2229 0.344515426565451 3146 5374726
SGTC_1534 6-azauridine 81.6 µM -0.401365155461255 0.323159902830661 no 2230 0.344075649792823 3119 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2713 st079149 53.4 µM -0.402145341647352 0.322843285099394 no 2231 0.3437885326209 3177 3103253
SGTC_2682 pyrogallin 40.03 µM -0.402863334360833 0.322552020340247 no 2232 0.343524382918129 3143 822798 An ATP competetive kinase inhibitor.
SGTC_1745 st081495 74 µM -0.403363569519157 0.322349156607664 no 2233 0.343340391422893 3178 13842402 YBL026W LSM2
SGTC_482 fipronil 114 µM -0.404015013214912 0.322085051557373 no 2234 0.343100839569479 3178 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_245 methotrexate 289.6 µM -0.404719635394435 0.3217994882662 no 2235 0.34284180365278 3192 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1393 3470-5649 58.2 µM -0.406282475711592 0.32116648932017 no 2236 0.342267530023033 3166 4108395
SGTC_1030 k029-0042 36.7 µM -0.40643790896375 0.321103562377099 no 2237 0.342210435193819 3152 6080581
SGTC_2399 5884133 200 µM -0.407727638531896 0.320581615388812 no 2238 0.341736821946405 3119 722445
SGTC_1304 1165-0502 251 µM -0.408220337207062 0.320382316288558 no 2239 0.341555959305779 3132 767425
SGTC_2600 tangeritin 87.95 µM -0.409226642992271 0.319975421482772 no 2240 0.341186671887606 3093 68077 A bioactive flavone.
SGTC_168 3970-0862 530.542 µM -0.409417675445009 0.319898202881053 no 2241 0.341116585227789 3208 3135186
SGTC_556 4058-0063 51.5 µM -0.410241951698813 0.319565105759025 no 2242 0.340814234728406 3170 6615692
SGTC_854 0422-0053 192 µM -0.411857741673746 0.318912573521859 no 2243 0.340221848015554 3193 3596728
SGTC_1711 st032263 62.8 µM -0.412159408986168 0.318790808101768 no 2244 0.34011129328182 3148 3958979
SGTC_597 k018-0003 82.8 µM -0.412320057837629 0.31872597155325 no 2245 0.340052424460376 3258 6786234
SGTC_273 hydroxyurea 18.1 mM -0.413070714539938 0.318423086276744 no 2246 0.339777402449802 3118 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3302 9125395 16.351 µM -0.414034174329841 0.318034514089667 no 2247 0.339424539627438 3151 17599668
SGTC_1056 3448-1962 115 µM -0.414658470023339 0.317782836771867 no 2248 0.339195969254696 3205 715507
SGTC_2698 st077697 67.5 µM -0.415029986974137 0.317633104107863 no 2249 0.339059975619287 3152 3154499
SGTC_2508 celastrol 40.54 µM -0.415615085579429 0.317397352001244 no 2250 0.338845843021385 3174 122724 Celastrol is a natural product and antioxidant.
SGTC_379 3970-0972 5.9 µM -0.415854739222481 0.317300810417765 no 2251 0.338758150341066 3189 2898042 YBL034C STU1
SGTC_1310 1188-0297 994 nM -0.416974222846647 0.31685000464875 no 2252 0.338348631168462 3148 1588352
SGTC_2157 5649910 96.377 µM -0.417298961542917 0.316719286186575 no 2253 0.338229873995811 3124 2858091
SGTC_2988 9073640 71.4286 µM -0.417326654440699 0.316708139904157 no 2254 0.338219747427869 3323 9102229
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.417772632586344 0.316528658380429 no 2255 0.33805668101519 3240 140250 A respiratory chain inhibitor.
SGTC_415 dibenzyl ketone 100 µM -0.418631582809676 0.316183100189466 no 2256 0.337742702075356 3199 7593
SGTC_2240 6690706 185.951 µM -0.419213381865459 0.315949131871739 no 2257 0.3375300965287 3026 805876
SGTC_1526 st051518 75 µM -0.419868080484042 0.315685935405695 no 2258 0.337290913457986 3145 673993
SGTC_717 1532-0246 73.2 µM -0.42019680212685 0.31555382070846 no 2259 0.337170845348674 3190 9561992
SGTC_2386 9075165 157.42 µM -0.420456495676039 0.315449465375875 no 2260 0.337076002006806 3198 16452277
SGTC_2325 6158266 200 µM -0.421115993404438 0.315184518776784 no 2261 0.336835191716149 3189 3623240
SGTC_3120 9124077 49.47 µM -0.421145470037794 0.315172679052735 no 2262 0.336824430121127 3197 18774327 YGL155W CDC43
SGTC_2721 ifenprodil 61.44 µM -0.42121876941872 0.315143238099579 no 2263 0.336797669901548 3273 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_3143 9086658 49.47 µM -0.424164806224836 0.313960925712259 no 2264 0.335722812710108 3199 25236626
SGTC_1021 4476-0760 85.3 µM -0.424327481513632 0.313895695832522 no 2265 0.33566349990673 3141 746768
SGTC_793 0488-0545 106 µM -0.424395165987548 0.313868557282796 no 2266 0.335638822773932 3120 292548
SGTC_2273 7815444 169.05 µM -0.424854734719779 0.313684316710808 no 2267 0.335471287018049 3284 2824616
SGTC_474 dl-dihydrosphingosine 5 µM -0.425013145414162 0.313620820811744 no 2268 0.335413545986968 3284 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2139 5578692 56.4705 µM -0.426012289545694 0.313220460283753 no 2269 0.335049445482605 3218 650991 YMR113W FOL3
SGTC_1174 0739-0097 51.1 µM -0.426041624265358 0.313208709082656 no 2270 0.335038757887118 3168 728447
SGTC_633 0437-0093 97.7 µM -0.426986419360576 0.312830334920676 no 2271 0.334694609678191 3174 2831118
SGTC_693 4161-2696 114 µM -0.427989746996631 0.312428735276188 no 2272 0.334329292560273 3254 805759
SGTC_3276 9139060 49.47 µM -0.429648861387365 0.311765134087453 no 2273 0.333725544124085 3197 4870619
SGTC_1880 MG-132 525 µM -0.42978648956786 0.311710113915401 no 2274 0.333675480807776 3272 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1046 2001-0062 216 µM -0.43083560338569 0.311290843658338 no 2275 0.333293954909105 3149 739778
SGTC_2478 5763493 32.33 µM -0.431971794740086 0.31083704951406 no 2276 0.332880956443339 3136 1365576 YLR208W SEC13
SGTC_3248 9135562 49.47 µM -0.432422060115376 0.310657293313105 no 2277 0.332717343833296 3214 17650701
SGTC_970 1315-0089 19.5 µM -0.432690620061508 0.310550099574437 no 2278 0.332619772559644 3236 6811083 YLR033W RSC58
SGTC_1965 Pectolinarigenin 58.4 µM -0.432748324802318 0.310527069248131 no 2279 0.332598809166583 3165 5320438 An anti-inflammatory.
SGTC_543 3844-1095 191 µM -0.433217440949896 0.310339869598723 no 2280 0.332428404711634 3240 4230703
SGTC_1307 1187-1599 12.2 µM -0.434082642372296 0.3099947419629 no 2281 0.332114214805329 3136 1538471
SGTC_247 mechlorethamine 29.705 µM -0.434233469868376 0.309934594207332 no 2282 0.332059455263643 3154 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1681 tripelennamine 100 µM -0.434472974829585 0.309839093653824 no 2283 0.33197250778562 3252 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1628 st004252 77.7 µM -0.435334600295329 0.309495634026854 no 2284 0.331659786769354 3279 692968
SGTC_3016 9080866 49.47 µM -0.435576885366528 0.309399084726293 no 2285 0.331571872192463 3161 17066299
SGTC_1481 3346-2004 36 µM -0.436614635833326 0.308985695655411 no 2286 0.331195423293689 3263 2770522
SGTC_3028 9087778 49.47 µM -0.436651271605315 0.308971106170269 no 2287 0.331182136608257 3159 17217395
SGTC_3233 9132340 49.47 µM -0.436934722348616 0.308858237600133 no 2288 0.331079344789469 3177 17682950
SGTC_2911 7942208 15.64 µM -0.437107121875572 0.308789597856784 no 2289 0.331016831295498 3245 1243384
SGTC_977 1348-1378 135 µM -0.437610793977407 0.308589102370531 no 2290 0.330834222617082 3133 X977
SGTC_146 3448-8650 53.125 µM -0.437761040180794 0.308529305287954 no 2291 0.330779757944092 3173 2891488 YIL048W NEO1
SGTC_2312 7706453 155.7 µM -0.438123767385572 0.308384962979408 no 2292 0.330648283073183 3170 976098
SGTC_382 3229-0966 23.2 µM -0.438878936998693 0.308084548636722 no 2293 0.330374629737579 3322 5722370
SGTC_2889 9059656 51.95 µM -0.438986068582008 0.308041940982657 no 2294 0.33033581544963 3260 3949838
SGTC_2330 7979373 200 µM -0.439497825344068 0.307838444224359 no 2295 0.330150428705455 3133 1863007
SGTC_2785 7756463 72.73 µM -0.439498360401937 0.307838231492978 no 2296 0.330150234899566 3138 2201551
SGTC_2844 9010103 25.97 µM -0.439515983666145 0.307831224770482 no 2297 0.330143851517579 3312 2480525
SGTC_2649 anisomycin 9.56 µM -0.44000886419092 0.307635291902836 no 2298 0.329965343634117 3240 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_108 0509-0257 621.132 µM -0.440558726369734 0.307416772077888 no 2299 0.329766244231769 3207 536624
SGTC_2553 4-methylesculetin 85.09 µM -0.441272145969205 0.307133355024516 no 2300 0.329507994263622 3233 5319502
SGTC_2022 5136654 200 µM -0.441720467225815 0.306955311338726 no 2301 0.329345748534607 3283 1713771
SGTC_3126 9127922 49.47 µM -0.442253302139874 0.306743763590045 no 2302 0.329152959423941 3356 45595682
SGTC_2878 9043973 25.97 µM -0.442490134543184 0.306649756318619 no 2303 0.329067283844732 3315 6465167
SGTC_94 0334-0113 514.748 µM -0.442733131693265 0.306553315257213 no 2304 0.328979387462055 3204 6795178
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.443046570919776 0.306428936824375 no 2305 0.328866024895059 3188 6708784 An antioxidant flavonoid
SGTC_2134 5324836 1.464 µM -0.443347151131423 0.306309682028029 no 2306 0.328757327874869 3155 699272
SGTC_2939 9044578 71.43 µM -0.444392100762679 0.305895259358251 no 2307 0.328379561755868 3137 2653634
SGTC_1583 clindamycin 39.6 µM -0.445044825584995 0.305636517413554 no 2308 0.328143680191789 3176 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1148 3909-7663 27.7 µM -0.447058438015768 0.304838927551654 no 2309 0.327416433375549 3306 4084526
SGTC_3335 9143315 29.6265 µM -0.44968188184644 0.303801174176983 no 2310 0.326469918667115 3197 4899691
SGTC_2452 5863136 48.41 µM -0.450275283789288 0.303566661438768 no 2311 0.326255979207812 3170 2184096
SGTC_579 4491-1009 110 µM -0.45105431191495 0.303258911927387 no 2312 0.32597520264113 3335 1271041
SGTC_1409 3909-8004 61.9 µM -0.451964395967161 0.302899566462537 no 2313 0.325647315964278 3245 2119279
SGTC_1774 st048371 48.465 µM -0.45214959435053 0.302826464477047 no 2314 0.325580608870865 3163 4242727
SGTC_1416 3966-0321 25.3 µM -0.452435160851638 0.302713760412998 no 2315 0.325477760868078 3227 582530 YLR208W SEC13
SGTC_137 0438-0332 85.389 µM -0.452669133739977 0.302621432722633 no 2316 0.325393504429482 3313 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2405 ticlatone 3.52 µM -0.452829877884627 0.302558009030623 no 2317 0.325335623709223 2987 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1564 D-Arginine 115 µM -0.453219655458187 0.302404241966801 no 2318 0.325195290172495 3231 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1037 k284-1091 78.7 µM -0.453934838034589 0.302122193978622 no 2319 0.32493786395316 3265 3334711
SGTC_2364 9055074 200 µM -0.455805917962325 0.301384851729728 no 2320 0.324264774077638 3276 6470630
SGTC_2188 6126565 140.678 µM -0.455883914212617 0.301354133101557 no 2321 0.324236728669238 3300 874518
SGTC_3356 9151811 4.48 µM -0.456091231562765 0.301272488535548 no 2322 0.324162187629413 3169 1859254 YPR165W RHO1
SGTC_1802 st050112 57.9 µM -0.457640460450035 0.300662695462351 no 2323 0.323605385028004 3241 4662563
SGTC_2621 lithochol-11-enic acid 100 µM -0.457828580083394 0.300588687507491 no 2324 0.323537800496821 3332 6708711
SGTC_1626 st003712 1.76 µM -0.458462904795078 0.300339199110609 no 2325 0.323309953649777 3327 24207035
SGTC_2135 5326629 150.42 µM -0.45894110333974 0.300151179111908 no 2326 0.32313823047923 3203 5020077
SGTC_2728 chlorpromazine 9.18 µM -0.459123823009007 0.300079350725964 no 2327 0.323072625002383 3221 2726 A thorazine and dopamine antagonist.
SGTC_1444 4112-3581 28 µM -0.460461248389592 0.299553836322853 no 2328 0.322592590247601 3246 2877249
SGTC_90 0870-0863 4.608 µM -0.460476231124051 0.299547951521779 no 2329 0.32258721424956 3185 1738164
SGTC_2775 cyproheptadine 69.59 µM -0.460993115621585 0.299344965769876 no 2330 0.3224017721542 3313 2913 A selective serotonin reuptake inhibitor.
SGTC_17 0960-0276 49.807 µM -0.461345915169039 0.299206453665185 no 2331 0.322275224007364 3225 6821114
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.461464473594452 0.299159913148299 no 2332 0.322232702076203 3150 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1922 5578187 25 µM -0.461476440194012 0.299155215801118 no 2333 0.322228410288438 3384 1350412
SGTC_2249 haloperidol 116.36 µM -0.461519244230359 0.299138413856737 no 2334 0.322213058933451 3263 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1226 3909-7979 35.4 µM -0.46175282583264 0.299046733202931 no 2335 0.322129291941334 3317 6615510
SGTC_2802 7925815 54.55 µM -0.462016673664299 0.298943188417882 no 2336 0.322034681745821 3183 1262923
SGTC_407 eburnamonine 100 µM -0.462163067796441 0.298885744340182 no 2337 0.321982192911809 3207 3195
SGTC_1257 0669-0121 16 µM -0.462769497667609 0.298647838749225 no 2338 0.321764798555073 3264 4307855
SGTC_1651 st011928 86.1 µM -0.463477359044982 0.298370250017593 no 2339 0.321511119964243 3308 720198
SGTC_2464 5717415 7.67 µM -0.464885152430314 0.297818531402685 no 2340 0.321006851867059 3226 5285744
SGTC_455 paf C-16 10 µM -0.465550093194366 0.297558100929083 no 2341 0.320768786403185 3225 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1460 k062-0059 9.15 µM -0.467786726333813 0.296682865892869 no 2342 0.319968556910181 3172 1373085
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.468138415291347 0.296545350967843 no 2343 0.319842804607484 3347 5377381
SGTC_1192 1488-0095 21.4 µM -0.469067703654327 0.296182127822361 no 2344 0.319510621575828 3304 915875
SGTC_166 k072-0058 166.424 µM -0.47054960538652 0.295603331966125 no 2345 0.318981201185138 3373 5846229
SGTC_1496 4469-0713 57.4 µM -0.473384473515286 0.294497550631812 no 2346 0.317969452521391 3331 746691
SGTC_978 1416-0512 87.4 µM -0.473690944949912 0.29437812144979 no 2347 0.317860155730395 3323 6814003
SGTC_3062 9077494 49.47 µM -0.474022290645209 0.294249024154476 no 2348 0.317742005891133 3323 16459633
SGTC_2540 epiandrosterone 100 µM -0.474500922709226 0.294062588048483 no 2349 0.31757137006867 3329 441302 A steroid.
SGTC_3094 9117742 49.47 µM -0.474846000292913 0.293928207783542 no 2350 0.31744837143002 3237 17149698
SGTC_2780 5215298 71.43 µM -0.474878658100672 0.293915491636744 no 2351 0.31743673200187 3362 2834131
SGTC_2867 9039098 71.43 µM -0.474978162416651 0.293876748673034 no 2352 0.317401269211474 3221 6463460
SGTC_1637 st007924 17.4 µM -0.47576013797263 0.293572361216542 no 2353 0.317122635790572 3246 683336
SGTC_1530 rhein 70.4 µM -0.475912583541409 0.293513038109854 no 2354 0.31706832847455 3306 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1632 st005650 90 µM -0.47741464878714 0.292928817197258 no 2355 0.316533442515632 3298 2759605
SGTC_638 3970-0837 4.09 µM -0.477418307075887 0.292927394982778 no 2356 0.316532140265416 3249 4118451 YLR208W SEC13
SGTC_286 k060-0067 22.9 µM -0.479149902576634 0.292254571365417 no 2357 0.315915995438076 3267 5985051
SGTC_805 3852-0218 479 µM -0.480042888261136 0.291907876681971 no 2358 0.315598448501253 3228 6615355
SGTC_736 0958-0254 92.6 µM -0.480355052710171 0.2917867264841 no 2359 0.315487474487094 3365 6812352
SGTC_187 1488-2104 32.728 µM -0.48046652432702 0.29174347032142 no 2360 0.315447850518423 3301 2852859
SGTC_2930 9013230 14.89 µM -0.482120699878762 0.291101924889929 no 2361 0.314860102911213 3340 2995857
SGTC_2040 5100729 123 µM -0.483006939713282 0.290758482282158 no 2362 0.314545404382402 3244 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_91 0417-1751 58.384 µM -0.483009876094746 0.290757344667584 no 2363 0.314544361914448 3353 6795624
SGTC_3002 9075603 71.4286 µM -0.485675047211162 0.289725661887408 no 2364 0.313598789027386 3349 20105405
SGTC_2019 4016004 108 µM -0.486870934159888 0.289263295285124 no 2365 0.313174898972909 3295 45595336
SGTC_1147 3809-1045 12.3 µM -0.487917070090039 0.288859111636211 no 2366 0.312804291468165 3275 325925
SGTC_3267 9137951 49.47 µM -0.488430553786263 0.288660820081124 no 2367 0.312622452246053 3214 16643986
SGTC_1228 0124-0032 52.5 µM -0.488643626224681 0.288578556907111 no 2368 0.31254701060316 3352 X1228
SGTC_921 1561-0023 372 µM -0.489850687468087 0.288112742395483 no 2369 0.312119779970657 3284 24050882
SGTC_1166 k206-0078 225 µM -0.492082944649251 0.287252232666876 no 2370 0.311330354330407 3314 5404595
SGTC_596 1155-0152 116 µM -0.493298179702637 0.286784285271534 no 2371 0.310900957191761 3313 280313
SGTC_1471 k673-0312 37 µM -0.493987966288867 0.286518831807427 no 2372 0.31065733906027 3334 24099884
SGTC_122 0236-0016 402.397 µM -0.495874244843104 0.285793523184648 no 2373 0.309991569168294 3342 6808838
SGTC_343 4130-2827 29.8 µM -0.496788151703665 0.28544242358411 no 2374 0.309669225659463 3295 1118244
SGTC_3211 9128781 49.47 µM -0.497472761563779 0.285179548638645 no 2375 0.309427853195186 3293 17194361
SGTC_2053 5265679 138 µM -0.499464394271392 0.284415462756951 no 2376 0.308726132174636 3267 764595
SGTC_160 3453-0671 289.699 µM -0.500401418924822 0.28405631380771 no 2377 0.308396227226597 3281 5322268
SGTC_521 r062-0005 13.8 µM -0.500731977439838 0.283929666960811 no 2378 0.308279882025056 3325 2832033
SGTC_2565 isoliquiritigenin 100 µM -0.502673335927086 0.283186420398885 no 2379 0.307596979707555 3353 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2235 salicylic acid 500 µM -0.503763665089127 0.282769399036564 no 2380 0.30721373185544 3356 338 A COX inhibitor and kinase inhibitor.
SGTC_1126 isoteolin 1.0172 µM -0.504657466528533 0.282427764405626 no 2381 0.306899719937137 3307 133323
SGTC_2099 5377090 177.372 µM -0.504836505678149 0.282359354764031 no 2382 0.306836836601104 3353 2243829
SGTC_1647 st011722 22.4 µM -0.505051178173925 0.28227734037365 no 2383 0.306761445374145 3396 2854783
SGTC_368 fentichlor 4.58 µM -0.505900100291864 0.281953126912103 no 2384 0.306463390955798 3313 7329 A pesticide.
SGTC_3154 9100113 49.47 µM -0.506970307560868 0.281544657805067 no 2385 0.30608782626274 3274 25237525
SGTC_696 1560-0013 611 µM -0.50928884779813 0.280660714142243 no 2386 0.305274886897444 3460 1650269
SGTC_196 k015-0023 18.111 µM -0.510331986606647 0.280263455747548 no 2387 0.304909448531892 3313 5211998
SGTC_1680 diphenhydramine 100 µM -0.511439405007155 0.279842016051984 no 2388 0.304521704212352 3288 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1045 1348-1485 165 µM -0.513240454788866 0.279157264847644 no 2389 0.303891565325018 3350 6810614
SGTC_2006 4011487 200 µM -0.514519140517908 0.278671609098395 no 2390 0.303444540893985 3438 45595294
SGTC_232 clozapine 119 µM -0.515080977912928 0.278458348627758 no 2391 0.303248217281466 3347 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1015 4130-4525 82 µM -0.515328618687238 0.278364375177135 no 2392 0.303161701860231 3287 1363237
SGTC_2971 9092186 9.93 µM -0.515778007144001 0.27819388303557 no 2393 0.303004732359294 3258 25236400
SGTC_3147 9097027 49.47 µM -0.515790934423611 0.278188979347232 no 2394 0.303000217452994 3290 25236841
SGTC_2183 6420625 130.508 µM -0.515965928683788 0.278122603147365 no 2395 0.302939102940265 3415 2897619
SGTC_1025 k007-0731 70 µM -0.517710634354271 0.277461250315562 no 2396 0.302330088718908 3272 6256118
SGTC_2017 5132927 60.65 µM -0.517761466636605 0.277441993224027 no 2397 0.302312353227619 3279 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_89 0302-0250 142.109 µM -0.518771376079118 0.277059538799063 no 2398 0.301960090480123 3425 4203518 YLR208W SEC13
SGTC_31 0508-1974 57.237 µM -0.519610466852793 0.276741970077424 no 2399 0.301667550678244 3388 6810525
SGTC_421 streptovitacin 30 mM -0.520168988856013 0.276530686466461 no 2400 0.301472898783626 3442 91467 include heat shock
SGTC_3352 9151559 45.5865 µM -0.52036283319257 0.276457375471363 no 2401 0.301405354826361 3325 17159339
SGTC_1827 berberine 7.24 µM -0.522071470701723 0.275811589546715 no 2402 0.300810284691638 3266 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2864 9034755 47.6 µM -0.522174014484016 0.275772856332201 no 2403 0.300774588455996 3425 4930451
SGTC_1902 st060212 70.5 µM -0.525504503299645 0.27451630720175 no 2404 0.299616261793232 3451 688944
SGTC_2304 7443016 91.4 µM -0.526345328138596 0.274199522385591 no 2405 0.299324147161934 3360 939854
SGTC_531 3788-1495 174 µM -0.526989651064405 0.273956892864314 no 2406 0.299100387582352 3301 2896655
SGTC_2381 9035592 200 µM -0.528201693309045 0.273500767825152 no 2407 0.298679677125006 3360 4749657
SGTC_1682 st012968 530 nM -0.528436747629074 0.273412353918389 no 2408 0.298598118873914 3279 24207270
SGTC_3317 9138495 8.753 µM -0.529905241084848 0.272860311782831 no 2409 0.298088816076929 3416 17020139
SGTC_2274 7947094 46.08 µM -0.531118900811483 0.272404485434015 no 2410 0.297668193670142 3431 2971028
SGTC_1288 0973-0013 65.5 µM -0.531951400592011 0.272092033996157 no 2411 0.297379827932716 3432 4315430
SGTC_2715 st079500 56.4 µM -0.532606275502887 0.271846373490979 no 2412 0.297153078561739 3353 28246688
SGTC_3140 9094243 49.47 µM -0.534134454587156 0.271273543590229 no 2413 0.296624256721803 3459 19291112
SGTC_2974 9094440 9.66 µM -0.534297743968357 0.271212371020877 no 2414 0.296567776415455 3467 25236134
SGTC_70 0141-0289 43.283 µM -0.534546453604676 0.271119210955768 no 2415 0.296481759491081 3346 352408
SGTC_2750 bromebric acid 70.15 µM -0.534919220902983 0.270979612054455 no 2416 0.296352858291155 3443 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_797 k781-0471 270 µM -0.536959986913471 0.270215994743598 no 2417 0.295647626715287 3330 23738129
SGTC_2821 7996764 71.43 µM -0.537126003672854 0.270153921673082 no 2418 0.29559028991709 3527 2987135
SGTC_2250 alverine citrate 130 µM -0.537430827274667 0.270039967795243 no 2419 0.295485027054944 3378 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2526 patulin 37.61 µM -0.537719319493416 0.269932141324501 no 2420 0.29538541969083 3450 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_3311 9131146 2.8755 µM -0.538003324913642 0.269826012887462 no 2421 0.295287376570357 3374 4900406 YPR165W RHO1
SGTC_2725 haloperidol 53.21 µM -0.538258032663689 0.269730850310349 no 2422 0.295199460205711 3369 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1265 0819-1001 68.8 µM -0.539287174893102 0.269346518819606 no 2423 0.294844358436058 3442 3106768
SGTC_2499 avocadenofuran 51.48 µM -0.539581119467499 0.269236796133097 no 2424 0.294742970096325 3293 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1672 st016598 6.51 µM -0.539818979419632 0.269148024948532 no 2425 0.294660938420969 3348 4665860 YNL267W PIK1
SGTC_1771 st048882 4.1505 µM -0.539986496585369 0.269085515053286 no 2426 0.29460317245312 3301 4580403
SGTC_548 1436-0017 110 µM -0.540408130091317 0.268928212586202 no 2427 0.294457801123876 3488 9677137
SGTC_2043 5101342 149 µM -0.541636420195017 0.268470227058415 no 2428 0.294034498564889 3356 678451
SGTC_972 1319-0219 195 µM -0.542722655464945 0.268065535697827 no 2429 0.29366038656315 3391 23903702
SGTC_159 3970-0959 50 µM -0.54359915402494 0.267739208550241 no 2430 0.293358671032653 3519 6615653
SGTC_878 0828-0289 13.7 µM -0.543894948752238 0.267629127093462 no 2431 0.293256882570311 3421 745350 YLR208W SEC13
SGTC_1273 0849-0096 14.1 µM -0.545443279945761 0.267053280564545 no 2432 0.292724340364039 3399 5286025
SGTC_1339 1486-1321 22.7 µM -0.546994197262822 0.266477100100242 no 2433 0.292191359354798 3379 3469382
SGTC_1949 st076024 69.1 µM -0.547861138820869 0.266155297320297 no 2434 0.291893627136441 3313 2921930
SGTC_1182 1222-0449 220 µM -0.548564436352218 0.265894382720294 no 2435 0.291652198759002 3410 658318
SGTC_843 0310-0051 143 µM -0.54888479426743 0.2657755769146 no 2436 0.291542256977361 3397 2065037
SGTC_2755 lomerizine 42.69 µM -0.550633272305108 0.265127622549172 no 2437 0.2909425477742 3371 3949 A calcium channel blocker.
SGTC_201 4262-0159 12.803 µM -0.551019734397992 0.264984515022857 no 2438 0.290810073253628 3377 1341029
SGTC_1724 st037281 8.293 µM -0.552169536890968 0.264558973561549 no 2439 0.290416101754752 3401 574124 YDL195W SEC31
SGTC_2211 7117706 200 µM -0.552278794545491 0.264518555441444 no 2440 0.290378678413865 3424 822771
SGTC_1038 k292-0204 154 µM -0.553498861103039 0.264067424894446 no 2441 0.289960930118325 3401 4454212
SGTC_3268 9137683 49.47 µM -0.554372493011159 0.263744632687555 no 2442 0.289661973579782 3379 1953228
SGTC_2603 homopterocarpin 100 µM -0.554467841735447 0.263709415131297 no 2443 0.28962935403773 3441 101795 A weak amylase inhibitor.
SGTC_508 roscovitine 141 µM -0.554817776361579 0.26358018548221 no 2444 0.2895096534533 3437 160355 A CDKinase inhibitor.
SGTC_2824 7998404 51.95 µM -0.554823187846003 0.263578187293445 no 2445 0.28950780255327 3374 837851
SGTC_1568 digitonin 820 nM -0.555840262190721 0.263202770236253 no 2446 0.289160029448292 3503 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_72 0744-0168 198.391 µM -0.556312539950699 0.263028538500588 no 2447 0.288998608059816 3279 677577
SGTC_2334 9017922 200 µM -0.557192470019962 0.262704073819233 no 2448 0.288697966956305 3421 3163164
SGTC_2314 7727897 200 µM -0.557964270760722 0.262419649317513 no 2449 0.288434391144084 3361 900724
SGTC_2937 9044753 11.33 µM -0.557968892702203 0.262417946511746 no 2450 0.288432813057699 3429 6465530 YGL099W LSG1
SGTC_2883 9059145 45.46 µM -0.558018501434283 0.262399670125334 no 2451 0.288415875223124 3369 16476510
SGTC_3141 9094609 49.47 µM -0.558179916466404 0.262340207615452 no 2452 0.288360766777096 3303 25236309 YDL196W YDL196W
SGTC_1194 1488-0194 225 µM -0.559680674038471 0.261787684993817 no 2453 0.28784863335945 3397 1391452
SGTC_456 gingerol 170 µM -0.559974661162629 0.261679519930885 no 2454 0.287748360614112 3530 442793 A herb.
SGTC_308 4092-1169 104 µM -0.561019915052825 0.26129513123079 no 2455 0.287391980491054 3423 2268590 YDL196W YDL196W
SGTC_2793 7325131 81.82 µM -0.561238333285736 0.261214845295167 no 2456 0.287317537006356 3383 4176441
SGTC_1962 st076595 64.5 µM -0.5629928192905 0.2605703934224 no 2457 0.286719886804104 3423 279619
SGTC_2636 apigenin dimethyl ether 100 µM -0.563795908655395 0.26027567867494 no 2458 0.286446518266253 3489 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1243 0416-0003 5.65 µM -0.565515900066225 0.259645060969154 no 2459 0.28586145627255 3387 2141977
SGTC_1358 1509-0022 2.48 µM -0.565940474982637 0.259489516276163 no 2460 0.285717122895486 3462 3258434
SGTC_3159 9100096 49.47 µM -0.56737802951752 0.2589632200572 no 2461 0.285228686742153 3428 25236875
SGTC_581 0958-0271 211 µM -0.568007678324786 0.258732876342113 no 2462 0.28501487710298 3404 4591145
SGTC_594 1487-1584 10.8 µM -0.568558257983532 0.258531545348602 no 2463 0.284827979602552 3372 5013332
SGTC_3123 9126162 49.47 µM -0.568760207388664 0.258457718658645 no 2464 0.284759441351388 3452 25239884
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.568989854463797 0.258373779797231 no 2465 0.284681512539691 3457 442882
SGTC_913 3487-1245 167 µM -0.57011364172338 0.257963225354407 no 2466 0.284300311623174 3384 4016153
SGTC_1683 st010134 710 nM -0.571972938424855 0.257284710324625 no 2467 0.283670154161153 3445 3818134
SGTC_903 1134-0042 114 µM -0.572063738408905 0.257251598367379 no 2468 0.283639397146508 3405 701009
SGTC_1256 0570-0116 285 µM -0.574329582672231 0.256426032676733 no 2469 0.282872397125322 3426 410638
SGTC_1670 st016595 4.04 µM -0.574717811560194 0.256284719225619 no 2470 0.282741079657961 3467 597879
SGTC_2817 7995342 71.43 µM -0.574851854681098 0.256235937602641 no 2471 0.282695746704837 3345 18879975
SGTC_2079 5212404 121 µM -0.575308331139922 0.256069850793936 no 2472 0.282541394037141 3505 758462
SGTC_1888 azatryptophan 97.5 µM -0.575435710932044 0.256023514279628 no 2473 0.282498329144985 3458 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_200 k038-0079 37.545 µM -0.575737973522774 0.255913578750347 no 2474 0.28239615205307 3392 3436683
SGTC_2936 9038235 15.59 µM -0.576458084154023 0.255651767544878 no 2475 0.282152796917994 3462 4749415
SGTC_2851 9015922 71.43 µM -0.578131437826324 0.255043925589348 no 2476 0.281587691752649 3501 2996893
SGTC_1664 st014217 9.02 µM -0.578975042671954 0.25473777492664 no 2477 0.28130300663653 3544 3982782
SGTC_981 1488-1094 54.9 µM -0.580048265607216 0.25434857238558 no 2478 0.280941034931629 3466 3449522
SGTC_2923 7992654 58.14 µM -0.580260256375632 0.25427173116182 no 2479 0.280869562292224 3451 2985126
SGTC_1757 st041620 31.8375 µM -0.58029014498149 0.254260898286791 no 2480 0.280859486062622 3471 5289815
SGTC_371 0195-0006 7.36 µM -0.580436127894724 0.254207991479121 no 2481 0.280810273921523 3420 3928593
SGTC_59 0330-0160 1.33 µM -0.581062140318932 0.25398117890056 no 2482 0.280599286842347 3500 4293482
SGTC_523 1934-0222 13.7 µM -0.58277926272541 0.253359588266645 no 2483 0.280020953347278 3445 1361595
SGTC_629 3448-6466 76.7 µM -0.583352498805751 0.253152257545263 no 2484 0.27982801394022 3503 573744
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.58425922671188 0.252824490230285 no 2485 0.279522959817202 3473 65057 A dermal irritant. YDR527W RBA50
SGTC_1812 st052057 4.327 µM -0.585286172537178 0.252453536081249 no 2486 0.279177655419272 3461 3645418
SGTC_1840 st055363 71 µM -0.585553744220546 0.252356930759629 no 2487 0.279087720102748 3443 676033
SGTC_2131 toluylene red 5.2905 µM -0.585788450545701 0.25227220734574 no 2488 0.279008842982581 3425 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2170 morpholine 200 µM -0.586286282480439 0.25209255148496 no 2489 0.27884157384756 3496 121171 Reacts with secondary amines.
SGTC_120 rhodamine 6G 52.259 µM -0.586721501210001 0.25193554657182 no 2490 0.278695382438309 3449 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2245 6637752 200 µM -0.586817584061169 0.251900891692539 no 2491 0.278663112920268 3456 681890
SGTC_1646 st011709 75.6 µM -0.588242398681256 0.251387289196078 no 2492 0.27818480119775 3496 5757843
SGTC_1377 2944-0135 198 µM -0.589408896767904 0.250967214433892 no 2493 0.277793504903328 3502 1894137
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.591582292540977 0.250185531511935 no 2494 0.277065167133068 3470 4330530
SGTC_2058 5236698 133 µM -0.592025836004477 0.250026165589516 no 2495 0.27691664392426 3454 766665
SGTC_3296 9122258 64.045 µM -0.592173297242725 0.249973194448224 no 2496 0.276867274274034 3484 4730474
SGTC_2366 9070441 60.58 µM -0.592368687540073 0.249903015367554 no 2497 0.27680186473631 3455 6837235
SGTC_753 1322-0200 289 µM -0.592382644236883 0.249898002887564 no 2498 0.27679719283345 3543 5403907
SGTC_1221 2958-7315 257 µM -0.592929449028402 0.249701662606694 no 2499 0.276614184309347 3508 4562705
SGTC_1080 nisoldipine 24.4 µM -0.592987567687704 0.249680798854582 no 2500 0.276594736229531 3437 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3285 9112818 20.8695 µM -0.594360604193314 0.24918816817596 no 2501 0.27613547602245 3516 17017947 YPR165W RHO1
SGTC_420 mitomycin C 81.9 mM -0.594830543565381 0.249019677819638 no 2502 0.275978374348049 3485 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_50 0929-0078 56.389 µM -0.59763648517623 0.248014908503389 no 2503 0.275041257006693 3386 1377751
SGTC_3326 9140064 16.379 µM -0.600227488957314 0.247089029924509 no 2504 0.274177318006463 3481 1868434
SGTC_131 0141-0277 33.849 µM -0.600575658140304 0.246964754973128 no 2505 0.274061327429067 3506 1547771
SGTC_3182 9108849 49.47 µM -0.601517315867292 0.246628808798003 no 2506 0.273747741046427 3550 17133045
SGTC_2118 5526350 200 µM -0.603554483424305 0.245902866443299 no 2507 0.273069941038361 3499 743594
SGTC_310 1273-0058 1.06 µM -0.603662816436824 0.245864294235142 no 2508 0.273033920124958 3542 2734232
SGTC_2227 7312221 64.1025 µM -0.604092702263245 0.245711264454235 no 2509 0.272891005568947 3529 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2572 astragaloside iv 100 µM -0.604608021937019 0.245527889546815 no 2510 0.272719737631897 3535 45006101 An anti-inflammatory agent.
SGTC_3203 9113543 49.47 µM -0.604726402270332 0.245485774659314 no 2511 0.272680401131442 3513 17018012
SGTC_3273 9137859 49.47 µM -0.604729229651156 0.245484768840156 no 2512 0.272679461657898 3569 2377234
SGTC_395 anisomycin 6.25 µM -0.604753297674686 0.245476206914051 no 2513 0.272671464472905 3489 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2537 larixol 68.93 µM -0.604764791460353 0.245472118186907 no 2514 0.272667645424709 3538 6708759
SGTC_1707 st032323 6.317 µM -0.60503616180074 0.245375593237657 no 2515 0.272577484725112 3470 3132057 YMR211W DML1
SGTC_2181 6316240 54.2555 µM -0.605861155381928 0.245082272838792 no 2516 0.272303477899886 3509 12779990
SGTC_795 0685-0265 78 µM -0.606836806533569 0.244735630795522 no 2517 0.271979609586086 3593 302754
SGTC_1852 st056254 31.4 µM -0.606872352646395 0.244723006495351 no 2518 0.271967813638674 3457 442583
SGTC_709 3807-1509 243 µM -0.60696141702466 0.24469137657522 no 2519 0.271938258817798 3563 1886677 YPL242C IQG1
SGTC_731 3966-0296 387 µM -0.608091242238559 0.244290326704078 no 2520 0.271563480186765 3542 660956
SGTC_576 1073-0113 22.7 µM -0.608319062781601 0.244209501037088 no 2521 0.271487940139818 3674 5439563
SGTC_2355 9061122 103.12 µM -0.609364574794398 0.243838761583072 no 2522 0.271141406718921 3499 5302957
SGTC_1515 3460-0031 42.1 µM -0.609402162042461 0.243825438771517 no 2523 0.27112895258926 3497 2876596
SGTC_495 decylubiquinone 155 µM -0.610993630055098 0.243261703087591 no 2524 0.270601898693647 3503 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1268 0828-0275 2.46 µM -0.611566468562514 0.24305896268052 no 2525 0.270412314418591 3551 745337
SGTC_2774 tamoxifen 10.92 µM -0.611669026095894 0.24302267491456 no 2526 0.270378379406907 3571 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1522 st012842 45.6 µM -0.611805689506803 0.24297432407559 no 2527 0.270333162493061 3481 3491067 YOR116C RPO31
SGTC_178 4092-0806 87.505 µM -0.613765195572014 0.242281633076451 no 2528 0.269685249718255 3545 2169044
SGTC_1068 loratadine 26.9 µM -0.614290525258302 0.242096109621485 no 2529 0.269511681208157 3514 3957 A H1 histamine antagonist.
SGTC_2243 6634756 200 µM -0.614682383036183 0.241957772778913 no 2530 0.269382248175625 3605 885676
SGTC_1571 st070080 73.4 µM -0.615795244563415 0.241565135194275 no 2531 0.269014833188159 3586 4315245
SGTC_1419 3993-2473 62.6 µM -0.616078024515751 0.241465420490149 no 2532 0.268921512526489 3552 704026
SGTC_2132 5317594 122.667 µM -0.616146484739348 0.241441283205222 no 2533 0.268898922303294 3520 794577
SGTC_2424 5537928 59.2 µM -0.617730705187497 0.240883094736342 no 2534 0.268376434039709 3538 5382802
SGTC_3187 9109394 49.47 µM -0.617762503409115 0.240871898057261 no 2535 0.268365951967413 3493 17098090
SGTC_984 1492-0255 2.91 µM -0.618334134117461 0.240670665744017 no 2536 0.268177552833641 3496 1585198
SGTC_1469 k284-2957 126 µM -0.619709250970531 0.240186955638905 no 2537 0.267724612011809 3557 23884841
SGTC_150 3970-0969 77.2 µM -0.620258659271861 0.239993844412447 no 2538 0.267543753813384 3550 6615640
SGTC_2735 sertaconazole 140 nM -0.620559797889429 0.239888033293463 no 2539 0.267444648967285 3589 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1660 st012960 28.1 µM -0.62106941314637 0.2397090276896 no 2540 0.267276976560558 3525 24207266
SGTC_1883 5-benzylidenerhodanine 20 µM -0.621855081523158 0.239433199541894 no 2541 0.267018581778226 3536 1273210
SGTC_667 1498-1044 59 µM -0.622178164233911 0.239319823747295 no 2542 0.266912361239641 3539 6739982
SGTC_300 r073-0011 5.04 µM -0.624280703403178 0.238582720155303 no 2543 0.266221627162433 3612 2735780
SGTC_282 k297-0036 65.7 µM -0.624478685909391 0.23851337595024 no 2544 0.2661566318508 3562 5061378
SGTC_3274 9138298 49.47 µM -0.625317364723461 0.238219747572558 no 2545 0.265881392663635 3526 17015756
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.625572904107631 0.238130320503341 no 2546 0.265797557947088 3564 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_834 0312-0008 75.7 µM -0.625598230901905 0.238121458288556 no 2547 0.265789249724371 3568 6385573 YIL048W NEO1
SGTC_259 usnic acid 108.925 µM -0.627002419706376 0.237630395043582 no 2548 0.26532882452003 3628 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_850 0388-0143 75.9 µM -0.631518906727181 0.236054694797736 no 2549 0.263850645488484 3535 67273
SGTC_2117 5521686 200 µM -0.631899895910884 0.23592204008229 no 2550 0.263726145694047 3546 803312
SGTC_1588 farnesol 29.9 µM -0.632784752578579 0.235614104863596 no 2551 0.263437107535993 3583 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_881 0833-0569 170 µM -0.633221259967158 0.235462279478461 no 2552 0.263294582117232 3515 5418700
SGTC_949 1165-0505 146 µM -0.633301550740587 0.235434358734405 no 2553 0.263268370409369 3563 6244267
SGTC_3156 9099931 49.47 µM -0.63341875323896 0.235393605389594 no 2554 0.263230110900797 3550 18111053
SGTC_2959 9079155 11 µM -0.633701461619705 0.235295318798914 no 2555 0.263137835446743 3569 16189457
SGTC_1319 1306-0155 43.7 µM -0.635143419154411 0.234794359499422 no 2556 0.262667440634974 3597 3122360
SGTC_2400 5203494 178.7 µM -0.635267590621866 0.234751247918481 no 2557 0.262626953597433 3559 6777674
SGTC_922 1866-0035 480 µM -0.635572422706182 0.234645430627773 no 2558 0.262527574355933 3567 3156169
SGTC_612 0302-0167 22.4 µM -0.636574949514425 0.23429760653625 no 2559 0.26220087332474 3593 235821
SGTC_2993 9054257 71.4286 µM -0.637008660634439 0.234147220064203 no 2560 0.262059601163561 3583 6470217 YGL055W OLE1
SGTC_1685 st024049 53.0905 µM -0.638795644597461 0.233528159293807 no 2561 0.261477941008831 3571 1941139
SGTC_3175 9106517 49.47 µM -0.640331808866101 0.232996715797176 no 2562 0.260978452605066 3555 41468073
SGTC_860 0443-0016 25.1 µM -0.641551194475162 0.232575342054463 no 2563 0.260582315317178 3595 5337942
SGTC_1027 k015-0025 8.67 µM -0.643605796324326 0.231866308358627 no 2564 0.259915545314453 3577 3598955
SGTC_2137 5261020 140 µM -0.643669658578034 0.231844289096732 no 2565 0.259894834516953 3580 763655
SGTC_3312 9133330 71.43 µM -0.643970331834202 0.231740634697437 no 2566 0.259797336355695 3607 17617324
SGTC_315 k915-0449 187 µM -0.644479736667812 0.231565080909135 no 2567 0.259632196691683 3602 20970215 YNL149C PGA2
SGTC_499 genistein 192 µM -0.645121314125328 0.231344082607607 no 2568 0.259424286229003 3597 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_404 fumagillin 50 µM -0.645702009192334 0.231144157364217 no 2569 0.25923617957142 3560 12015870 A methionine aminopeptidase binder.
SGTC_738 1315-0003 72.4 µM -0.647596301799154 0.230492649419677 no 2570 0.258623044922228 3607 6251474
SGTC_1108 betulinic acid 729.144 nM -0.648924035681223 0.230036611703702 no 2571 0.258193739021142 3604 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3280 9140961 49.47 µM -0.649033850342031 0.229998916203317 no 2572 0.258158248392657 3570 4901226
SGTC_2942 9052777 62.25 µM -0.65103710023271 0.229311878196192 no 2573 0.257511269030166 3673 6469503
SGTC_2290 7904846 200 µM -0.651285472483613 0.229226776266183 no 2574 0.257431112240508 3598 2962154
SGTC_37 0566-0070 1.56 µM -0.653199699552667 0.228571482654983 no 2575 0.256813771957277 3608 1626686
SGTC_1933 st074711 15.9 µM -0.653773167062965 0.228375373661325 no 2576 0.256628978180529 3607 17250958
SGTC_2214 7179297 48.276 µM -0.654916069320497 0.22798481689959 no 2577 0.256260896768455 3616 769744
SGTC_3057 9095946 49.47 µM -0.655545450290838 0.22776990303687 no 2578 0.256058316836848 3617 24540043
SGTC_583 1488-1091 88.9 µM -0.655680419538861 0.227723830123626 no 2579 0.256014884933718 3674 4303273
SGTC_1303 1160-0052 261 µM -0.656095586064001 0.227582142350934 no 2580 0.255881312135832 3613 3562476
SGTC_416 estradiol valerate 100 µM -0.656302449007994 0.227511562827256 no 2581 0.255814771065358 3601 13791 A steroid.
SGTC_234 nsc-17383 10.7 µM -0.65793729438044 0.226954204157159 no 2582 0.2552892124921 3638 408974
SGTC_1163 k060-0048 49.9 µM -0.658114388263124 0.226893874792453 no 2583 0.255232315500687 3621 6809982
SGTC_491 tetrandrine 80.3 µM -0.658203622562896 0.226863479380006 no 2584 0.255203648681712 3605 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.658701398961598 0.226693966560722 no 2585 0.255043767234752 3577 689007
SGTC_424 splitomicin 100 mM -0.659664568853674 0.226366171648804 no 2586 0.254734554297267 3579 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_901 1112-0062 60.1 µM -0.659803462914137 0.22631892402945 no 2587 0.254689980398063 3613 1908457
SGTC_730 1436-0052 41.2 µM -0.660472165222643 0.226091529421299 no 2588 0.25447543755118 3628 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2952 9073731 13.78 µM -0.661578516312324 0.225715594489507 no 2589 0.254120689876871 3608 16457353
SGTC_520 3584-0023 682 µM -0.661946129863627 0.22559075877297 no 2590 0.254002873294135 3570 1340790
SGTC_2231 micatex 6.853 µM -0.662051703938997 0.225554914718563 no 2591 0.253969043123513 3628 20737 An antifungal of unknown mechanism.
SGTC_3020 9089140 49.47 µM -0.662696204981109 0.225336166418235 no 2592 0.253762570409401 3620 17217859
SGTC_1429 4049-0205 9.46 µM -0.663289639915695 0.225134856595036 no 2593 0.253572535226347 3643 22774478
SGTC_703 3875-0075 71.8 µM -0.66380858743424 0.224958898537733 no 2594 0.253406414381403 3649 2850814
SGTC_800 3448-7362 155 µM -0.664808370203781 0.224620124875061 no 2595 0.253086534168531 3694 15991913
SGTC_1669 st015249 58.4 µM -0.668033080224509 0.223529414979613 no 2596 0.252056238348834 3691 722793
SGTC_948 3448-0295 75.3 µM -0.668562351704613 0.223350685062999 no 2597 0.251887347602095 3649 678569
SGTC_879 0831-1030 162 µM -0.672046859689338 0.222176032089475 no 2598 0.250776932502097 3653 1549252
SGTC_1347 1493-0251 600 nM -0.672497241796346 0.222024462729566 no 2599 0.250633597730237 3651 3986378
SGTC_2379 9035213 200 µM -0.67354285255077 0.221672805783266 no 2600 0.250300997952802 3650 646551
SGTC_682 0kpi-0099 17 µM -0.673767515398921 0.221597289347986 no 2601 0.250229565189209 3647 1714895 YML126C ERG13
SGTC_1232 0279-0259 161 µM -0.674767226467928 0.221261432516525 no 2602 0.249911832793183 3658 1560000
SGTC_3307 9126885 69.2785 µM -0.674770289972325 0.221260403767953 no 2603 0.249910859466479 3626 24824909
SGTC_145 3737-0113 38.366 µM -0.675135688059013 0.221137719877753 no 2604 0.249794780802062 3670 6849351
SGTC_1316 1272-0050 65.9 µM -0.675800823386631 0.220914497929015 no 2605 0.249583555933313 3632 7340392
SGTC_653 0203-0016 55.2 µM -0.676791722076395 0.220582187901074 no 2606 0.249269055510941 3653 295302
SGTC_3206 9114350 49.47 µM -0.677785318811061 0.220249260801627 no 2607 0.248953910463984 3588 17087243
SGTC_1853 st056710 91.2 µM -0.677967474976514 0.220188256519224 no 2608 0.248896157906583 3713 269167
SGTC_2433 5607874 27.82 µM -0.679110371691549 0.219805720462486 no 2609 0.248533965638238 3637 2252428
SGTC_2612 dictamnine 15.46 µM -0.6799336394911 0.219530403118728 no 2610 0.248273240194055 3609 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_430 0958-0115 16.4 µM -0.680968895782215 0.219184473869139 no 2611 0.247945585995906 3622 6833180
SGTC_1675 st018485 24.5 µM -0.681102212738877 0.219139949006503 no 2612 0.247903408526456 3661 3323024
SGTC_509 pifithrin 175 µM -0.682476818394727 0.218681164993465 no 2613 0.24746874808752 3677 4817 A p53 inhibitor.
SGTC_1131 3454-3128 32.3 µM -0.683226187995975 0.218431290801333 no 2614 0.247231963529927 3701 710982
SGTC_895 0964-0006 13.7 µM -0.683561507088705 0.218319533312549 no 2615 0.247126049208065 3624 6738897
SGTC_3234 9132280 49.47 µM -0.683793476002674 0.218242240372834 no 2616 0.247052793411369 3662 17612295
SGTC_2593 nobiletin 86.24 µM -0.684197331764203 0.218107711698587 no 2617 0.246925283462078 3608 72344 An anti-infammatory.
SGTC_828 2074-0507 139 µM -0.684323974603659 0.218065535460456 no 2618 0.246885305594817 3691 X828
SGTC_662 k832-1615 104 µM -0.68524416031802 0.21775922451548 no 2619 0.246594930838572 3646 5878478
SGTC_2307 7538926 6.34 µM -0.685636322621246 0.21762875719925 no 2620 0.246471235314622 3660 96582
SGTC_1461 k072-0203 53.8 µM -0.686201352251483 0.21744085850053 no 2621 0.246293072591657 3596 5418714
SGTC_2795 7780010 54.55 µM -0.686343339270688 0.21739365592498 no 2622 0.246248312710003 3636 953673
SGTC_1135 dihydrocapsaicin 536.708 nM -0.686423468406651 0.217367020174885 no 2623 0.246223054786441 3617 107982 A Capsaicinoid.
SGTC_3066 9117245 49.47 µM -0.687130039523709 0.217132230241402 no 2624 0.246000392957336 3712 17176980
SGTC_3097 9117246 49.47 µM -0.687356568446823 0.21705698687922 no 2625 0.245929029751016 3688 16423892
SGTC_1137 ixabepilone 100 µM -0.687390693252518 0.217045653362774 no 2626 0.245918280406558 3674 154225 A novel microtubule stabilizer.
SGTC_2893 9048488 25.97 µM -0.687667026889901 0.21695389014598 no 2627 0.245831244350942 3619 6467338
SGTC_3050 9093513 49.47 µM -0.688871220951258 0.216554270469467 no 2628 0.245452155719065 3660 25236664
SGTC_463 ikarugamyin 104 µM -0.689197042804841 0.216446217602248 no 2629 0.24534963876221 3702 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.689564458468965 0.216324408344457 no 2630 0.245234062295412 3615 641818 YHR062C RPP1
SGTC_1516 st013856 110 µM -0.689662467710653 0.216291922061526 no 2631 0.245203236869085 3649 5281404 A mutagen and neurotoxin.
SGTC_2323 6148992 148.28 µM -0.690324613199733 0.216072520380774 no 2632 0.244995036439792 3631 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3310 9130229 44.1445 µM -0.690601361788816 0.215980858042765 no 2633 0.24490804572643 3684 7761258
SGTC_2416 tofa 880 nM -0.690822858258044 0.21590751207987 no 2634 0.244838434454633 3639 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1285 0929-0069 65.5 µM -0.690901142328815 0.215881592678589 no 2635 0.24481383410984 3669 1206237
SGTC_2801 7907800 81.82 µM -0.691296810593387 0.215750616804034 no 2636 0.244689517861316 3700 6620925
SGTC_963 1269-2853 151 µM -0.693155253149286 0.215136043453379 no 2637 0.244106063033597 3658 3668223
SGTC_253 dyclonine 31.25 µM -0.693729039927959 0.214946501885928 no 2638 0.243926075369462 3729 3180 An oral anasthetic.
SGTC_119 0121-0043 24.815 µM -0.693835446355825 0.214911362835496 no 2639 0.243892705260652 3733 1092378
SGTC_3275 9138069 49.47 µM -0.6944074629166 0.214722520544763 no 2640 0.243713357430376 3701 17617007
SGTC_841 0251-0215 91.2 µM -0.694911425973199 0.214556224977174 no 2641 0.243555405846575 3707 3888614
SGTC_1474 0330-0125 5.35 µM -0.696690896561517 0.213969642130696 no 2642 0.24299812855447 3675 X1474
SGTC_2753 fluvastatin 17.09 µM -0.697340774253325 0.213755650067344 no 2643 0.242794778256211 3682 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_3072 9116419 49.47 µM -0.69841622322935 0.213401799617892 no 2644 0.242458466778328 3649 17170162
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.698484345854029 0.213379397022729 no 2645 0.24243717215847 3696 5379071
SGTC_2865 9030313 51.95 µM -0.700056501459376 0.212862763835928 no 2646 0.241946009769042 3615 42562754
SGTC_2805 7950783 58.44 µM -0.700101086854383 0.212848123080869 no 2647 0.241932088571982 3685 1178958 YDL195W SEC31
SGTC_776 4476-4378 112 µM -0.701574869421774 0.212364499787734 no 2648 0.241472164214885 3701 2892008
SGTC_1104 tacrolimus 29.8 µM -0.702162263072538 0.212171925051487 no 2649 0.241288988308722 3718 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2674 ligustilide 100 µM -0.702977586481965 0.211904793694874 no 2650 0.241034858788527 3656 5319022 A signalling regulator.
SGTC_1657 st012939 43.4 µM -0.703177964265946 0.211839172344858 no 2651 0.240972424988769 3691 24207257
SGTC_1187 1391-0724 117 µM -0.703639532953408 0.211688059313162 no 2652 0.240828642680642 3737 6997986
SGTC_2723 salbutamol 83.58 µM -0.703967126769948 0.211580846621193 no 2653 0.240726622935156 3648 9884233 β2-adrenoceptor agonist
SGTC_2626 ethyl orsellinate 100 µM -0.704437590773379 0.211426931959363 no 2654 0.240580151499625 3675 75653 A natural product.
SGTC_2517 totarol 10 µM -0.704936302871884 0.211263847408686 no 2655 0.240424938465434 3648 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1321 1326-2144 215 µM -0.705524668844335 0.211071539812965 no 2656 0.240241892811483 3681 3513030
SGTC_2178 5812956 200 µM -0.705547688608977 0.211064017882238 no 2657 0.240234732711133 3676 5403383
SGTC_3309 9129340 25.759 µM -0.707767516073694 0.210339406175736 no 2658 0.239544821000512 3717 17158987
SGTC_2365 9042475 200 µM -0.709029349160661 0.209928161672931 no 2659 0.239153132047457 3724 6464479
SGTC_401 neomycin 50 µM -0.712455705556393 0.208813862960145 no 2660 0.238091315488837 3684 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1550 gossypolone 36.6 µM -0.713019193131474 0.208630943254379 no 2661 0.237916940269899 3697 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3138 9097216 49.47 µM -0.713627916971475 0.208433445097305 no 2662 0.23772864507589 3707 25237486
SGTC_1696 st025591 34.7925 µM -0.713922000142415 0.208338070435065 no 2663 0.237637706276964 3686 2787147
SGTC_1893 st059353 36.1 µM -0.714976907675564 0.207996163265464 no 2664 0.237311656249275 3706 3112488
SGTC_2683 piperine 63.03 µM -0.715996641557253 0.207665971344744 no 2665 0.236996711332783 3682 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_518 1021-0119 62.6 µM -0.716466482703437 0.207513940093125 no 2666 0.236851678189922 3700 1097762
SGTC_2326 6164455 177.58 µM -0.716495563866366 0.20750453216939 no 2667 0.236842702861013 3694 2888790
SGTC_355 1311-2252 105 µM -0.71850619367755 0.206854693258217 no 2668 0.236222615160536 3704 5338538
SGTC_149 3970-0822 46.1 µM -0.718684558796515 0.206797103582948 no 2669 0.236167649727999 3743 3114250 YBL034C STU1
SGTC_2448 5185112 27.17 µM -0.719205930158567 0.206628820125834 no 2670 0.236007023049734 3689 5718189
SGTC_1199 1638-0010 4.46 µM -0.721002852499201 0.206049447811719 no 2671 0.235453879857826 3695 3111136
SGTC_2732 terfenadine 20 µM -0.721760889645843 0.205805327046542 no 2672 0.235220749460098 3709 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_3245 9134821 49.47 µM -0.722087996491384 0.205700037513713 no 2673 0.235120188825369 3698 17014901
SGTC_1847 st056231 15 µM -0.723250398080334 0.205326141075487 no 2674 0.234763030370401 3711 5393180
SGTC_1204 4049-0315 18.3 µM -0.724090307643412 0.205056228370888 no 2675 0.234505147295013 3784 588402
SGTC_3235 9132602 49.47 µM -0.724577959526566 0.204899613743345 no 2676 0.234355492198393 3726 4912240
SGTC_1054 3429-0080 167 µM -0.725418979471531 0.204629678338327 no 2677 0.234097516487183 3726 1162877
SGTC_3110 9122132 49.47 µM -0.727399095280792 0.203994972558773 no 2678 0.233490754284264 3834 918317
SGTC_1842 st055362 61.2 µM -0.727795505387407 0.203868048434476 no 2679 0.233369388154084 3714 676032
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.727905759861551 0.203832755097164 no 2680 0.233335638529624 3732 5106787 A p450 inhibitor.
SGTC_317 4495-0002 170 µM -0.730261055915925 0.203079676224663 no 2681 0.23261531406029 3736 15991618
SGTC_2285 7945142 200 µM -0.730720994054317 0.202932810397192 no 2682 0.23247479475373 3759 2970608
SGTC_2807 7945238 51.95 µM -0.731973436863058 0.202533206463128 no 2683 0.23209239052793 3758 17148797
SGTC_2818 7996756 12.99 µM -0.732780394302134 0.202275988286503 no 2684 0.231846190480063 3735 2241621
SGTC_1623 st003709 20.3 µM -0.732798628272174 0.202270178455811 no 2685 0.231840629037252 3715 16192618
SGTC_1360 1598-0022 39.8 µM -0.732971088650731 0.202215232902004 no 2686 0.231788031522062 3782 761525
SGTC_1775 st081588 35.1725 µM -0.73322026587066 0.202135861278536 no 2687 0.231712048402885 3762 1426443 YGL099W LSG1
SGTC_441 propafenone 146 µM -0.733892744052518 0.201921746614856 no 2688 0.231507054845199 3701 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2611 pyromycin 23.93 µM -0.733973506779533 0.201896041184784 no 2689 0.231482442501089 3729 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.734015170427869 0.201882781105903 no 2690 0.23146974612471 3734 688761
SGTC_96 0929-0093 37.281 µM -0.73479363698017 0.20163511838457 no 2691 0.231232591449296 3697 6991579
SGTC_2049 5262831 67.185 µM -0.735973463636265 0.201260113380657 no 2692 0.230873423622924 3771 763417
SGTC_1640 st009078 66.4 µM -0.736150925447683 0.201203743778936 no 2693 0.230819426912431 3728 690618
SGTC_2892 9047358 58.44 µM -0.736266495989429 0.201167038631108 no 2694 0.230784265792377 3727 6466771
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.737677107225069 0.200719352871311 no 2695 0.230355343356415 3805 688664
SGTC_88 0180-0332 8.668 µM -0.739405806351622 0.200171531836827 no 2696 0.229830308778476 3798 3101745
SGTC_237 nikkomycin 200 µM -0.739477895828139 0.200148706371774 no 2697 0.229808428571918 3747 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1431 4049-0260 9.09 µM -0.740190418961622 0.19992318655899 no 2698 0.22959223016283 3712 3854841
SGTC_2106 5357045 167.29 µM -0.740602947097828 0.199792687664507 no 2699 0.229467110291065 3766 668842
SGTC_674 0498-0004 451 µM -0.740952551266896 0.199682134220484 no 2700 0.229361105192077 3740 4231473
SGTC_2838 9002687 71.43 µM -0.741430987973927 0.199530900421587 no 2701 0.229216080680824 3745 6457060
SGTC_666 0272-0154 136 µM -0.742843185307386 0.199084907202032 no 2702 0.228788313163302 3789 6870312
SGTC_2083 5306046 65.942 µM -0.74410414239699 0.198687185938073 no 2703 0.228406736722675 3771 539837
SGTC_818 4072-2707 53.5 µM -0.745431208436737 0.198269130979241 no 2704 0.228005541644506 3667 882871
SGTC_1391 3442-0225 151 µM -0.745445663519151 0.198264580235689 no 2705 0.228001173805795 3708 5227075
SGTC_2190 6049624 200 µM -0.746284461374984 0.198000618197742 no 2706 0.227747797983308 3659 2265554
SGTC_2926 9010726 65.15 µM -0.746591749652876 0.197903970521863 no 2707 0.227655015036014 3767 2994293
SGTC_62 0180-0423 3.232 µM -0.746611146983643 0.197897870669729 no 2708 0.227649158899591 3714 30102 YGL099W LSG1
SGTC_1353 1498-1206 8.11 µM -0.746716761020326 0.197864660360464 no 2709 0.227617275062024 3792 6756808
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.746763575669944 0.197849940581823 no 2710 0.227603142984612 3718 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1386 3228-0095 33.8 µM -0.747023856480867 0.197768113394349 no 2711 0.227524580252236 3737 870181
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.749056244431914 0.197129873964735 no 2712 0.226911653067543 3722 6708514
SGTC_3210 9128157 49.47 µM -0.749273318556972 0.197061779002337 no 2713 0.226846242984839 3815 17590849
SGTC_2875 9039966 71.43 µM -0.749976772662127 0.196841207142553 no 2714 0.226634347058676 3806 6463691
SGTC_3078 9116413 49.47 µM -0.750476907817603 0.196684478006969 no 2715 0.226483763267813 3689 17177322
SGTC_524 r073-0010 27.8 µM -0.750703375950264 0.196613533751217 no 2716 0.22641559542602 3707 2772106
SGTC_1082 camptothecin 424.86 nM -0.751277430735226 0.196433772663048 no 2717 0.226242854488048 3703 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1769 st044406 64.4 µM -0.751783479089321 0.196275389929453 no 2718 0.226090639384406 3760 670903
SGTC_957 1187-1561 14.1 µM -0.754790207677902 0.195335943246505 no 2719 0.225187435161157 3735 1538454
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.755289258906824 0.195180280387266 no 2720 0.225037721025047 3748 803109
SGTC_1006 4099-6547 255 µM -0.758229765819185 0.194264616212835 no 2721 0.224156722371414 3800 3146833
SGTC_3122 9126309 49.47 µM -0.75831472410548 0.194238199423576 no 2722 0.224131297358382 3805 17591206
SGTC_929 2805-0021 398 µM -0.75840887855309 0.194208925750948 no 2723 0.224103122172723 3843 3098024
SGTC_2589 lobaric acid 100 µM -0.758890864005968 0.194059113161966 no 2724 0.223958922265432 3783 73157 A novel microtubule depolymerizer.
SGTC_1956 st077085 54 µM -0.758953877696247 0.194039532207689 no 2725 0.223940073792613 3815 24208685
SGTC_1819 st053448 58.6 µM -0.759449390480278 0.193885597889403 no 2726 0.223791888857459 3711 2857616
SGTC_277 nystatin 15.5 µM -0.760479019787078 0.193565974840391 no 2727 0.223484152703847 3757 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2779 methotrexate 400 µM -0.760770347201033 0.193475597782655 no 2728 0.223397124323245 3807 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2197 6588183 93.1375 µM -0.761272054455646 0.193320015980589 no 2729 0.223247294278038 3719 884136
SGTC_3146 9095609 49.47 µM -0.761778606296213 0.193163009329264 no 2730 0.223096075489789 3840 17173999
SGTC_2253 7938677 135.83 µM -0.763532411563001 0.192620015805159 no 2731 0.222572970156985 3811 2301972
SGTC_1629 st005085 44.9 µM -0.76357271252354 0.192607549248323 no 2732 0.222560957864339 3780 24207091
SGTC_1164 k060-0068 93.7 µM -0.763582756541986 0.192604442343889 no 2733 0.222557964154802 3798 5963676
SGTC_1193 1488-0126 41.5 µM -0.763752209146757 0.192552030386327 no 2734 0.222507460751609 3788 1384710
SGTC_1240 0356-0016 42.1 µM -0.764189534503539 0.192416805253756 no 2735 0.222377151151474 3776 4305613
SGTC_2822 7994718 71.43 µM -0.766283972429925 0.191769990575985 no 2736 0.221753676412086 3743 1018011
SGTC_1477 0139-0234 16 µM -0.769215060742447 0.190867035779125 no 2737 0.220882825554903 3793 620880
SGTC_1323 1348-1351 11.2 µM -0.771251557245856 0.190241208473468 no 2738 0.22027891993246 3745 6989654
SGTC_95 0471-0001 561.058 µM -0.771362228483505 0.190207234708395 no 2739 0.22024612846679 3717 4015405
SGTC_419 nsc-638432 893 µM -0.77144791409837 0.190180933569588 no 2740 0.220220742068463 3767 368090
SGTC_944 3370-0224 231 µM -0.772442845114706 0.189875703833212 no 2741 0.219926093008768 3822 4580514
SGTC_909 3448-9333 149 µM -0.77446600975504 0.189255957248676 no 2742 0.219327630583979 3731 3344074
SGTC_2656 pseudo-anisatin 100 µM -0.775099251183244 0.189062235545493 no 2743 0.219140507023389 3843 6708809 A neurotoxin.
SGTC_209 4077-0173 175.592 µM -0.778373666465593 0.188062473723159 no 2744 0.218174379228086 3754 15993494
SGTC_1075 aripiprazole 15.2 µM -0.778585740801743 0.187997834779602 no 2745 0.218111890699517 3827 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1964 st076914 61 µM -0.77889784684104 0.187902731741387 no 2746 0.21801994620504 3840 24208661
SGTC_3077 9117319 49.47 µM -0.779330842160032 0.187770841267247 no 2747 0.217892425492828 3779 17154678
SGTC_1302 1159-0335 255 µM -0.779953743884736 0.187581205580327 no 2748 0.217709051238696 3814 649284
SGTC_301 4119-0100 24.5 µM -0.780675737586414 0.187361550545527 no 2749 0.217496617031674 3828 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3074 9116018 49.47 µM -0.780860644657124 0.187305321112863 no 2750 0.217442230564349 3850 17027303
SGTC_2356 9061756 188.97 µM -0.781431044608083 0.187131930721514 no 2751 0.217274509070454 3816 20104043
SGTC_3303 9125618 40.5795 µM -0.782826731033377 0.186708088248664 no 2752 0.216864433987916 3843 22695467
SGTC_3193 9111931 49.47 µM -0.784976829377856 0.186056309745753 no 2753 0.216233576961876 3847 17087244
SGTC_1495 4469-0029 237 µM -0.785034743899985 0.186038773130106 no 2754 0.216216599060297 3802 793680
SGTC_3109 9122853 49.47 µM -0.785528180695312 0.185889401191272 no 2755 0.216071977160122 3870 1234709
SGTC_2720 fluspirilene 36.88 µM -0.78583127695316 0.185797685542688 no 2756 0.215983170150425 3786 3396 An atypical antipsychotic.
SGTC_1074 carmofur 3.8 µM -0.786287191394047 0.185659780629603 no 2757 0.215849627345052 3835 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2729 fluphenazine 10.66 µM -0.787272410601134 0.185361988683175 no 2758 0.215561208315784 3739 3372 An atypical antipsychotic.
SGTC_2471 5466956 24.79 µM -0.790613677640851 0.184354268665448 no 2759 0.214584731414955 3777 724419
SGTC_1049 3226-0134 66 µM -0.791339473401911 0.184135821448251 no 2760 0.21437295985603 3848 5702385
SGTC_1111 tnp00062 510.699 nM -0.792376308596093 0.183824038398878 no 2761 0.214070644632253 3888 676306
SGTC_729 4092-0585 94.1 µM -0.7969495233879 0.18245277049891 no 2762 0.212740173673641 3825 2169061
SGTC_2996 9066192 71.4286 µM -0.797595972979022 0.182259450853145 no 2763 0.212552494352807 3886 6472854
SGTC_806 3966-4455 5.86 µM -0.799253710014682 0.181764292725029 no 2764 0.212071657018161 3816 714982
SGTC_2339 9000433 200 µM -0.800105993543307 0.181510047583063 no 2765 0.211824694451105 3875 2988954
SGTC_1181 1222-0449 220 µM -0.801043735903453 0.181230566506115 no 2766 0.211553163362799 3845 658318
SGTC_1863 st057641 20.1 µM -0.80454101319071 0.18019063032422 no 2767 0.210542296507694 3854 3921635
SGTC_2092 5303694 80.6725 µM -0.807347498279355 0.179358819828105 no 2768 0.209733152910179 3833 1963699
SGTC_1052 3253-3998 198 µM -0.808093266033703 0.179138189355188 no 2769 0.209518446925019 3799 5450317
SGTC_177 1327-0068 8.361 µM -0.810205655207198 0.178514180103562 no 2770 0.208910993884061 3840 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1857 st056007 79.3 µM -0.814209677533296 0.177335136383658 no 2771 0.207762421196592 3855 619834
SGTC_54 0159-0055 9 µM -0.814745795738635 0.177177642528675 no 2772 0.207608916810557 3835 3319099
SGTC_566 0958-0068 16.5 µM -0.816428969483573 0.17668375589273 no 2773 0.207127416699419 3788 6815365
SGTC_1763 st044482 94.5 µM -0.817011009891603 0.176513172951142 no 2774 0.206961068102779 3895 88505
SGTC_668 1682-0499 62.6 µM -0.817095427031834 0.176488440840131 no 2775 0.206936948040592 3878 682214
SGTC_1375 2910-0797 186 µM -0.817244818645511 0.176444678205386 no 2776 0.206894267243621 3869 742508
SGTC_484 loperamide 105 µM -0.817911289246264 0.176249526585757 no 2777 0.20670392179875 3825 3955 An opioid-receptor agonist.
SGTC_3135 9127742 49.47 µM -0.818370406024094 0.176115170464462 no 2778 0.206572857394716 3941 3643468
SGTC_3082 9117008 49.47 µM -0.819310576032007 0.175840241112368 no 2779 0.206304620024522 3933 41448529
SGTC_965 1291-5240 308 µM -0.823694107323103 0.174561977469989 no 2780 0.205056694255545 3847 2834598
SGTC_1281 0884-0031 11.8 µM -0.82609448340885 0.173864520444467 no 2781 0.204375248401204 3873 1548255
SGTC_1053 3366-3204 134 µM -0.826168039657056 0.173843175849496 no 2782 0.204354387734054 3890 3632071 YPR165W RHO1
SGTC_2665 lovastatin 100 µM -0.82742388916002 0.173479009858656 no 2783 0.203998422460467 3898 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_3112 9123419 49.47 µM -0.827785245469015 0.173374315283601 no 2784 0.20389606601527 3898 17015854
SGTC_510 ag-490 170 µM -0.829515694552242 0.172873515625089 no 2785 0.203406329821306 3996 5328779
SGTC_3053 9095903 49.47 µM -0.830640294558704 0.172548546111328 no 2786 0.203088432191059 3956 17174018
SGTC_262 fenpropimorph 62.5 µM -0.832941576636831 0.171884772267229 no 2787 0.202438839855273 3840 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2349 9023730 187.07 µM -0.833225642919135 0.171802950374728 no 2788 0.202358741532504 3878 4126287
SGTC_2924 9010168 62.78 µM -0.833505613095119 0.171722332660635 no 2789 0.202279816739323 3987 2993929
SGTC_976 1348-1067 47.6 µM -0.834188961324041 0.171525663287444 no 2790 0.202087255275891 3916 5310671 YGL099W LSG1
SGTC_330 1488-0319 80.1 µM -0.834225590047835 0.171515125512645 no 2791 0.202076936725202 3921 6846614
SGTC_1929 genistein trimethyl ether 50.5 µM -0.83442098024988 0.171458920389666 no 2792 0.202021899356277 3825 136420
SGTC_2286 7945697 125 µM -0.835126596873097 0.171256043708445 no 2793 0.201823216496331 3915 1245733
SGTC_885 0865-0106 16.8 µM -0.836116819758069 0.170971596863989 no 2794 0.201544593475347 3814 2793380
SGTC_617 3770-0098 35 µM -0.836713170863657 0.170800437712353 no 2795 0.201376906996743 3825 5962639
SGTC_3088 9117578 49.47 µM -0.837974425039272 0.17043880560413 no 2796 0.201022533649232 3930 678341
SGTC_1134 3477-0009 42.5 µM -0.838232599479536 0.170364841246462 no 2797 0.2009500407802 3982 3973534
SGTC_1356 1502-0781 85.8 µM -0.8409969406599 0.169574174463758 no 2798 0.200174824155342 3847 567702
SGTC_2133 5320837 200 µM -0.841904544553191 0.169315092524667 no 2799 0.199920693170307 3905 2841355
SGTC_1278 0874-0585 172 µM -0.84261210891005 0.169113289632815 no 2800 0.199722708321736 3950 766306
SGTC_2687 chenodiol 100 µM -0.845699385735367 0.168234582233879 no 2801 0.198860232957913 3963 5702181 A cholesterol synthesis inhibitor.
SGTC_2377 9073351 62.6 µM -0.846604008229394 0.167977664025307 no 2802 0.198607939523351 3873 7337946 YHR072W ERG7
SGTC_3301 9125354 19.7965 µM -0.846880034979152 0.167899321083722 no 2803 0.1985309958822 3870 41905162
SGTC_3321 9137793 26.8275 µM -0.847680104113719 0.167672375394537 no 2804 0.198308074794217 3865 4904192
SGTC_1850 st056238 17 µM -0.848279505043882 0.167502480275931 no 2805 0.198141164368627 3909 5393177
SGTC_2449 5812982 45.77 µM -0.848379323395117 0.167474198385561 no 2806 0.198113376984323 3875 776185
SGTC_3247 9135149 49.47 µM -0.849466176245195 0.167166455622861 no 2807 0.197810971723544 3875 8934436 YOR116C RPO31
SGTC_722 3534-0461 190 µM -0.849950312694805 0.167029489660076 no 2808 0.197676355734244 3949 658262
SGTC_2601 securinine 100 µM -0.852748633399565 0.166239241481825 no 2809 0.196899357418818 3867 442872 A GABA receptor antagonist.
SGTC_2907 7721985 69.9 µM -0.853125320096091 0.166133049545659 no 2810 0.196794905744233 3948 3267881
SGTC_3290 9121031 71.43 µM -0.853195883222821 0.166113161933604 no 2811 0.196775342985692 3905 17014854
SGTC_2352 9027995 87.8 µM -0.853960887131944 0.165897650875663 no 2812 0.196563330668248 3865 2997347
SGTC_2731 amoxapine 43.43 µM -0.854440314667649 0.165762682367986 no 2813 0.196430533237627 3987 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_573 3702-0553 84.7 µM -0.854790090405878 0.16566425825436 no 2814 0.196333682588288 3863 1222756
SGTC_2270 7924575 90.91 µM -0.854810249576807 0.165658586775826 no 2815 0.196328101526074 3923 1262135
SGTC_680 0417-1641 114 µM -0.855120156967037 0.165571414809427 no 2816 0.196242315834478 3872 2835990
SGTC_2762 leflunomide 42.06 µM -0.856117806001771 0.165290993691131 no 2817 0.195966310255057 3879 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1614 st002383 48.6 µM -0.856738397952684 0.165116711651412 no 2818 0.195794738650685 3909 1947235
SGTC_838 0109-0203 71.4 µM -0.856768620632151 0.165108227196531 no 2819 0.195786385483278 3915 759422
SGTC_3121 9125696 49.47 µM -0.856882204947854 0.165076343036987 no 2820 0.195754994145013 3983 1235365
SGTC_541 4513-1321 94 µM -0.857439322148604 0.164920012855915 no 2821 0.195601067707755 3915 747515
SGTC_2300 7976697 71.57 µM -0.857761856319368 0.164829551810012 no 2822 0.195511988035175 3815 2236109
SGTC_2607 solasodine 47.35 µM -0.858668299934429 0.164575494003912 no 2823 0.195261772240267 3937 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_3098 9119039 49.47 µM -0.860619452519117 0.16402948691338 no 2824 0.194723834314204 3898 17161528
SGTC_1689 st020265 53.493 µM -0.861265796149562 0.163848874678215 no 2825 0.194545834650832 3894 5758320 YPR016C TIF6
SGTC_74 000s-0487 160.283 µM -0.861842816580547 0.163687742984448 no 2826 0.194387009927262 3843 677548
SGTC_365 0121-0052 13.6 µM -0.862492413426465 0.163506467620255 no 2827 0.194208303051585 3972 3101739
SGTC_2569 tetrandrine 100 µM -0.862591316740698 0.163478879274031 no 2828 0.19418110310577 3941 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2966 9084041 48.03 µM -0.862719795176763 0.163443045681539 no 2829 0.1941457730076 3856 17741380
SGTC_2815 7968870 71.43 µM -0.865610077460507 0.162638272868495 no 2830 0.193352013671266 3923 2977326 YHR190W ERG9
SGTC_1674 st016616 23.6 µM -0.866442892279179 0.162406862379752 no 2831 0.193123665430781 3892 625830
SGTC_660 4031-1742 102 µM -0.866631231777454 0.162354559060949 no 2832 0.193072047742874 3850 6738706
SGTC_453 enantio-paf c16 10 µM -0.870006323389088 0.161419129319514 no 2833 0.192148474277596 3819 13871343 A lipid and platelet activating factor
SGTC_1397 3532-0190 20.1 µM -0.871233984928997 0.161079747982447 no 2834 0.191813203607197 3849 5322280
SGTC_471 1-acyl-paf 4 µM -0.872194641365336 0.160814503940147 no 2835 0.191551101179092 3868 16759367
SGTC_1578 josamycin 24.2 µM -0.874580138558399 0.160157085254931 no 2836 0.190901199237531 3942 5282165 A P450 substrate.
SGTC_2895 9054447 58.44 µM -0.875651458635266 0.159862412890472 no 2837 0.1906097707911 3974 2697450
SGTC_764 1951-2361 146 µM -0.875956563346496 0.159778557117798 no 2838 0.190526823930729 3918 5438930
SGTC_1195 1502-0147 41.1 µM -0.876225228268679 0.159704740383076 no 2839 0.190453802074413 3918 817940
SGTC_43 0570-0105 72.5 µM -0.876341356069632 0.159672840725293 no 2840 0.190422244407127 3948 1114046 YDL195W SEC31
SGTC_1659 st012954 42.1 µM -0.878089852441455 0.15919304258343 no 2841 0.189947479708143 3928 24207262
SGTC_853 0419-0306 21 µM -0.879228348814981 0.158881140331446 no 2842 0.189638738242131 3957 762713
SGTC_3348 9149464 3.537 µM -0.881589540896131 0.158235546129006 no 2843 0.188999406582371 3918 1951442
SGTC_3344 9148862 3.898 µM -0.881695582709366 0.158206592756536 no 2844 0.188970725202016 3993 4905352
SGTC_2653 dihydrofissinolide 100 µM -0.8836173769789 0.157682473689386 no 2845 0.188451397680848 3990 6857746
SGTC_880 0833-0487 87.2 µM -0.884080919536345 0.15755622553525 no 2846 0.188326266203319 3938 76075
SGTC_642 0335-0876 158 µM -0.891684385304462 0.155494865537585 no 2847 0.18628106265299 3986 6812350
SGTC_3115 9123671 49.47 µM -0.893466684259629 0.155014256007518 no 2848 0.18580365284655 4056 3286988
SGTC_999 SEC7.066 22.7 µM -0.895215843093582 0.15454353771049 no 2849 0.185335858589124 3949 740511 YDR170C SEC7
SGTC_2945 9067681 61.76 µM -0.895642875248169 0.154428762190991 no 2850 0.185221764447591 4041 16456930
SGTC_3113 9123498 49.47 µM -0.895993444978144 0.154334579982959 no 2851 0.185128132091473 4018 8897275
SGTC_2943 9068529 45.32 µM -0.896351982603471 0.15423829645569 no 2852 0.185032402036242 3954 3270634
SGTC_2081 5214970 32.255 µM -0.897597219070074 0.15390420292995 no 2853 0.184700161085552 3882 2063512
SGTC_2136 5328288 199.296 µM -0.900771357467133 0.153054758097646 no 2854 0.183854949749624 3972 262395
SGTC_2733 amorolfine 100 µM -0.901313069931738 0.152910099138883 no 2855 0.183710943272064 4035 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2387 9077560 195.08 µM -0.902713169687371 0.152536636410755 no 2856 0.183339072508363 3948 5303272
SGTC_625 k213-0058 121 µM -0.903034813402411 0.152450926701069 no 2857 0.183253709299226 4045 3655420
SGTC_1062 mesoridazine 14.2 µM -0.903075805799001 0.152440005587001 no 2858 0.18324283182984 3978 4078 A neuroleptic.
SGTC_175 3793-3120 23.7 µM -0.904775520459632 0.151987628030898 no 2859 0.18279216140285 3988 5322297
SGTC_1227 3909-8010 46.6 µM -0.906583410881388 0.151507439212379 no 2860 0.182313568796563 3977 15982272
SGTC_36 0335-0881 14.2 µM -0.907754116599743 0.151197029906758 no 2861 0.182004072570694 3893 23828853
SGTC_2321 7390090 138.78 µM -0.907992466509918 0.151133883976373 no 2862 0.181941100940259 4006 649046
SGTC_3288 9119690 36.221 µM -0.908247607030805 0.151066309163852 no 2863 0.181873708360355 3984 17595618 YKL019W RAM2
SGTC_3279 9140807 49.47 µM -0.909166252105275 0.150823169506442 no 2864 0.181631187638399 4018 45595718
SGTC_1864 st057645 30.4 µM -0.909438320852708 0.150751210549659 no 2865 0.181559400816196 4019 688666
SGTC_954 1189-0853 2.85 µM -0.910394171971822 0.150498580521283 no 2866 0.18130733509793 3922 2828194
SGTC_2388 9080168 200 µM -0.911881088476721 0.150106151581949 no 2867 0.180915658945967 3952 15943073
SGTC_3046 9092212 49.47 µM -0.912489826033401 0.149945689751187 no 2868 0.180755461427643 4036 25236637
SGTC_2528 xanthyletin 44.79 µM -0.91416218543654 0.149505448603161 no 2869 0.18031581537575 4024 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_698 k064-0052 127 µM -0.914669857199456 0.149371977135503 no 2870 0.18018248657843 4054 5088751
SGTC_654 1124-0271 80.9 µM -0.915489964041171 0.149156531770971 no 2871 0.179967234356163 3973 5403748
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.917232492305634 0.148699451844076 no 2872 0.179510411880563 4082 688801
SGTC_2007 4011539 71.82 µM -0.917716910269085 0.148572551403695 no 2873 0.17938354610447 3968 45595301
SGTC_2357 9067248 200 µM -0.917967748064932 0.148506869200549 no 2874 0.179317875546658 3992 9150235
SGTC_3220 9131269 49.47 µM -0.919254182620294 0.148170319814522 no 2875 0.178981318332 4011 17722206
SGTC_429 1112-0049 25.5 µM -0.920253530785965 0.147909228743221 no 2876 0.178720143218828 3959 2836170
SGTC_1785 bathophenanthroline 24 µM -0.922073377121656 0.147434564742173 no 2877 0.178245151325594 3923 72812 An iron chelator.
SGTC_1993 st073995 70.8 µM -0.924010275278531 0.146930492976233 no 2878 0.177740483005568 3986 3098394
SGTC_1369 1866-0067 208 µM -0.924418298119352 0.146824453860165 no 2879 0.177634285714871 3990 3531355
SGTC_399 oxolinic acid 75 µM -0.925286974417035 0.14659886873932 no 2880 0.177408326206002 3965 4628 A DNA gyrase inhibitor.
SGTC_2417 cerulenin 830 nM -0.925452320604417 0.146555956624735 no 2881 0.177365337030321 4036 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2727 riluzole 51.77 µM -0.927949366677664 0.145908926053012 no 2882 0.17671691747753 4013 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1488 4013-0813 75.9 µM -0.928245211972786 0.145832394479712 no 2883 0.176640193379608 3939 2910057
SGTC_3250 9135583 49.47 µM -0.929303871471065 0.145558753205522 no 2884 0.176365814712725 4026 7699353
SGTC_526 4469-0568 170 µM -0.930166316879932 0.145336084531642 no 2885 0.17614248937033 3942 2901964
SGTC_830 4076-0286 57.8 µM -0.930390352044159 0.145278279992826 no 2886 0.17608450603778 4071 6866659
SGTC_1765 st044815 90.4 µM -0.93239427310004 0.144761925351437 no 2887 0.175566401675878 4052 645695
SGTC_1942 st076330 65.2 µM -0.932895973690164 0.144632844773929 no 2888 0.175436840715087 4041 24208414
SGTC_952 1185-0122 232 µM -0.933559277441932 0.144462305002653 no 2889 0.175265639836334 3945 678600
SGTC_1899 st063254 59.6 µM -0.934695979130406 0.144170366683249 no 2890 0.174972499827985 3954 3093813
SGTC_2512 diallyl trisulfide 49.23 µM -0.936102857746772 0.143809590176775 no 2891 0.174610115907874 4039 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_34 0469-0683 81.75 µM -0.937052788600032 0.143566337005754 no 2892 0.17436570236252 3980 3690923
SGTC_2833 9001315 45.46 µM -0.938992224076876 0.143070559613736 no 2893 0.173867368352445 3996 2989378
SGTC_3092 9117248 49.47 µM -0.940374236804235 0.142717982660604 no 2894 0.173512816223503 4101 17141857
SGTC_1167 k781-0610 148 µM -0.940829918842757 0.142601858644491 no 2895 0.173396013006395 4044 4525169
SGTC_3169 9102970 49.47 µM -0.941549241523649 0.142418679667411 no 2896 0.173211733695672 4077 17027839
SGTC_2059 5238311 157 µM -0.944529411202173 0.141661461400508 no 2897 0.172449589815272 4016 703021
SGTC_1436 4092-1007 8.32 µM -0.944757505569961 0.141603618466854 no 2898 0.172391345571281 4004 2881121
SGTC_679 0422-0091 41.4 µM -0.946781043885304 0.141091165765563 no 2899 0.171875181549003 4007 627384 YHR062C RPP1
SGTC_1478 0453-0656 35.7 µM -0.947132803975185 0.141002212449892 no 2900 0.171785555398224 4026 5258496
SGTC_3085 9117376 49.47 µM -0.950257564342162 0.140213690876799 no 2901 0.170990697760511 4120 16480349
SGTC_2005 4024620 188 µM -0.950845278254206 0.140065718776054 no 2902 0.170841461939151 4014 236743
SGTC_2880 9042983 58.44 µM -0.951024451829687 0.140020628329244 no 2903 0.170795981699451 4038 6464714
SGTC_2797 7859098 81.82 µM -0.956357398576552 0.138683064945458 no 2904 0.169445850037378 4032 972681
SGTC_3067 9117431 49.47 µM -0.957129713376845 0.138490083572348 no 2905 0.169250893901694 4087 17150885
SGTC_2100 5377183 190 µM -0.959689356850593 0.137851803955145 no 2906 0.168605790713453 4062 2844202
SGTC_1512 0259-0544 12.2 µM -0.960005056000706 0.137773219618803 no 2907 0.168526335155959 4004 18476
SGTC_2790 5423970 71.43 µM -0.960028151024228 0.137767471968814 no 2908 0.168520523516618 4122 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1502 4534-4282 27.7 µM -0.960040079845575 0.137764503311524 no 2909 0.168517521794542 3988 3278949
SGTC_769 0302-0231 76 µM -0.960643222481027 0.137614459563459 no 2910 0.168365794145065 3979 571869 YER009W NTF2
SGTC_2482 5981709 142.65 µM -0.964292504005237 0.136709007468978 no 2911 0.167449648991643 4003 877755
SGTC_904 1141-0088 396 µM -0.96751253074642 0.135913450983712 no 2912 0.166643940064651 4068 1378119
SGTC_2832 7992762 51.95 µM -0.968924867291808 0.135565513861901 no 2913 0.16629133858256 4003 2985177
SGTC_966 1300-0360 30.2 µM -0.969725569682454 0.135368527581782 no 2914 0.16609165079066 4034 70588
SGTC_1155 4088-0394 48.2 µM -0.970734260954939 0.135120651898971 no 2915 0.165840313099053 4034 2326248
SGTC_787 4152-0075 138 µM -0.971147024812186 0.135019309148005 no 2916 0.165737534797577 4061 9566539
SGTC_3221 9128209 49.47 µM -0.973196437549471 0.134516904581089 no 2917 0.165227840524602 4098 16460723
SGTC_170 4197-0004 226 µM -0.981322528883524 0.132537470042508 no 2918 0.163216858179591 4104 218692
SGTC_15 0266-0086 27.098 µM -0.981775004578026 0.132427844414636 no 2919 0.163105352388941 4127 1712902 YIL048W NEO1
SGTC_1001 4048-4355 44.4 µM -0.981888302536803 0.132400404415857 no 2920 0.163077439573432 4043 21824233
SGTC_3171 9103192 49.47 µM -0.984998641506435 0.131648631423381 no 2921 0.162312369128158 4099 13018434
SGTC_1897 st060201 15 µM -0.985779692846305 0.131460313945931 no 2922 0.162120616442841 4121 611878
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.986252041317802 0.131346517382938 no 2923 0.162004723736039 4007 97141
SGTC_1662 st014054 52 µM -0.987736872914373 0.130989239932012 no 2924 0.161640765517412 4112 2838777
SGTC_3099 9120367 49.47 µM -0.987768505953612 0.130981635760366 no 2925 0.161633017508475 4095 24824940
SGTC_214 4373-3496 70 µM -0.988446142366768 0.130818814018903 no 2926 0.161467099406565 4149 3779166
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.988536368102383 0.130797145234904 no 2927 0.161445016172311 4120 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_480 am 92016 50 µM -0.989786820986496 0.130497089526941 no 2928 0.161139163902403 4048 2129 K+ channel blocker.
SGTC_962 1254-0300 21.5 µM -0.990034011587522 0.130437830654409 no 2929 0.161078747546962 4050 7340576
SGTC_527 4476-4215 268 µM -0.990612402588948 0.130299246016037 no 2930 0.160937439596831 4064 4418754
SGTC_1376 2910-0861 41.3 µM -0.991469837698749 0.130093988860683 no 2931 0.160728106715654 4017 1112859
SGTC_2830 7992007 71.43 µM -0.992175161000289 0.129925312831349 no 2932 0.16055604352226 3959 1952075
SGTC_1513 0337-0559 19 µM -0.993866877908947 0.129521360883332 no 2933 0.160143840785803 4055 775073
SGTC_2319 6033012 152.6 µM -0.994324037859736 0.129412348705002 no 2934 0.160032568312443 4037 847246
SGTC_3325 9138760 55.175 µM -0.995662596519234 0.129093528071912 no 2935 0.15970705469305 4017 43844959
SGTC_3351 9150312 21.596 µM -0.999256952764781 0.128240112984122 no 2936 0.158835116407649 4008 4904905
SGTC_1959 st077091 55.8 µM -1.00309463129439 0.127333258658314 no 2937 0.157907602398888 4079 821356 YKL052C ASK1
SGTC_2070 5230947 200 µM -1.00414143712108 0.127086671659512 no 2938 0.157655222465406 4165 2835538
SGTC_3184 9108758 49.47 µM -1.00452771028376 0.126995764618925 no 2939 0.15756216080455 4101 902885
SGTC_126 0417-1624 672.48 µM -1.00469673058355 0.126956000956916 no 2940 0.157521451469241 4154 41912 YDL195W SEC31
SGTC_2419 paclitaxel 166.5 µM -1.00499835707805 0.12688506193726 no 2941 0.157448820481992 4022 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_258 haloperidol 50.781 µM -1.00706920236958 0.126398768430272 no 2942 0.15695075993881 4100 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2071 5230951 39.92 µM -1.00789430933092 0.126205372040137 no 2943 0.156752601927158 4127 1799272
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.00800567747366 0.126179284325415 no 2944 0.156725868327539 4046 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2069 5228469 200 µM -1.0085043882168 0.126062508659196 no 2945 0.156606191067974 4111 2835210
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.00956395630507 0.12581465553518 no 2946 0.156352122768249 4104 229346 A bile salt which induces apoptosis.
SGTC_2012 4023501 200 µM -1.00996273672286 0.125721461304889 no 2947 0.156256571648177 4130 3477460
SGTC_777 1315-0167 517 µM -1.01040978482296 0.125617044274112 no 2948 0.156149500931299 4112 4221767
SGTC_2087 5276107 200 µM -1.01065702996784 0.125559321216658 no 2949 0.156090304993756 4063 144405
SGTC_2982 9019404 25.97 µM -1.01177472844517 0.125298608854194 no 2950 0.155822887894266 4041 22333232
SGTC_1768 st044301 37.178 µM -1.01248264014437 0.125133678250955 no 2951 0.155653671455583 4115 3931349
SGTC_1299 1079-1439 3.74 µM -1.01905562207351 0.123609530081907 no 2952 0.154088280413105 4072 323161
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.02320439229737 0.122654228806825 no 2953 0.153105608317479 4149 279621
SGTC_2734 clemastine 41.6 µM -1.02325298410956 0.122643070762423 no 2954 0.153094123590821 4148 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2922 7999257 32.47 µM -1.02346105375138 0.122595300183361 no 2955 0.153044952566527 4067 2988377
SGTC_1269 0831-0796 3.05 µM -1.02670745560335 0.121851651184785 no 2956 0.152279118774852 4139 927758
SGTC_2268 7933382 153.85 µM -1.02876050141177 0.121383001585126 no 2957 0.151796115882922 4135 935025 YOR257W CDC31
SGTC_1197 1601-0112 267 µM -1.0309260023786 0.120890056686742 no 2958 0.151287760932942 4095 7350313
SGTC_1911 st060208 74.3 µM -1.03353302241761 0.12029847742758 no 2959 0.150677262514637 4175 688783
SGTC_2051 5263410 176 µM -1.03860394780016 0.119153642226704 no 2960 0.149494484507738 4130 227584
SGTC_2161 5662504 8.5105 µM -1.04128784693036 0.118550835158731 no 2961 0.148870987683278 4097 2859334
SGTC_926 2268-1401 59.4 µM -1.04267741605574 0.118239584362661 no 2962 0.148548860460968 4100 2931578
SGTC_1957 st077035 62.4 µM -1.04427499237239 0.117882456406037 no 2963 0.148179089740361 4137 705593
SGTC_641 4092-0595 30 µM -1.0448803627254 0.117747329330396 no 2964 0.148039133384459 4168 786260
SGTC_3070 9117005 49.47 µM -1.0470799291731 0.117257278375603 no 2965 0.147531357690068 4222 8779016
SGTC_1300 1094-0077 113 µM -1.04902784283866 0.116824501918897 no 2966 0.147082652009901 4116 5532636
SGTC_1838 st055369 84.5 µM -1.0502269550255 0.116558653652759 no 2967 0.146806889685223 4138 676036
SGTC_1743 st037606 46.3785 µM -1.05070412582576 0.116452982287062 no 2968 0.146697250258732 4118 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_836 0330-0104 1.35 µM -1.05172571865399 0.116226975032623 no 2969 0.146462703879036 4160 46494820
SGTC_3223 9129970 49.47 µM -1.05412655521933 0.11569706305656 no 2970 0.145912489879585 4163 17248386
SGTC_3041 9091929 49.47 µM -1.05560125139767 0.115372420542714 no 2971 0.145575214476473 4154 25236887
SGTC_1879 gemcitabine 100 µM -1.05632266996955 0.115213842079756 no 2972 0.145410411092605 4122 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2688 kanamycin b 96.69 µM -1.05648026984932 0.115179219929859 no 2973 0.1453744251331 4208 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_409 arachidonic acid 100 µM -1.05752128931674 0.114950710546622 no 2974 0.145136871857364 4141 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_269 exalamide 29 µM -1.05901850323245 0.114622629662247 no 2975 0.144795676516018 4076 3316 A derivative of salicylamide.
SGTC_3355 9151058 44.0485 µM -1.05995489100621 0.114417780276648 no 2976 0.144582560835465 4147 17015728
SGTC_782 0083-0095 30.5 µM -1.06254929531567 0.113851575806411 no 2977 0.143993195818064 4140 3591729 An indicator and reagent.
SGTC_2903 5923464 63.88 µM -1.06424628136352 0.113482306316755 no 2978 0.143608573024163 4165 2876576
SGTC_719 2810-4230 27.3 µM -1.06638238650817 0.113018698368519 no 2979 0.143125410251033 4147 721079
SGTC_2054 5233173 129 µM -1.06839167390437 0.112583849393545 no 2980 0.142671935603927 4195 6889
SGTC_2496 diffractaic acid 79.83 µM -1.07191652699868 0.111823891980941 no 2981 0.141878763139402 4191 94870 An apoptosis inducer which activates caspases.
SGTC_387 norethindrone acetate 66.7 µM -1.07337178782453 0.111511210554342 no 2982 0.141552168697882 4178 541197
SGTC_2072 5231554 129 µM -1.07380748605825 0.111417717025276 no 2983 0.141454487021371 4199 789545
SGTC_1485 3909-9022 254 µM -1.07467791693842 0.111231105193016 no 2984 0.141259476963825 4201 714516
SGTC_2299 7976368 114.88 µM -1.07651073873128 0.110838898114766 no 2985 0.140849450406622 4200 2979718
SGTC_2534 helenine 20.12 µM -1.07878469911658 0.110353669927397 no 2986 0.140341858672259 4168 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.07899292456038 0.110309314063122 no 2987 0.140295440905506 4144 15053
SGTC_550 4123-0385 25.7 µM -1.08232621035685 0.109601002489408 no 2988 0.139553801746497 4198 5731123
SGTC_2236 dapsone 200 µM -1.08279248312503 0.109502182104507 no 2989 0.139450271386699 4168 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1109 tnp00067 928.257 nM -1.08515983562498 0.109001439969655 no 2990 0.138925434841464 4171 676295
SGTC_1417 3966-0327 90.4 µM -1.08546447660479 0.108937122064914 no 2991 0.138857994444673 4274 651118
SGTC_3298 9116858 71.43 µM -1.08600455068797 0.108823164963714 no 2992 0.138738489461209 4245 2506942
SGTC_2702 st077768 96.8 µM -1.08607176672899 0.108808988195897 no 2993 0.138723621123733 4175 6484119
SGTC_3163 9099914 49.47 µM -1.08753569239255 0.108500555916047 no 2994 0.138400066734698 4195 16268368
SGTC_469 w7 172 µM -1.08785840641916 0.108432648479655 no 2995 0.138328810266522 4259 45115570 A P450 inhibitor.
SGTC_1237 0330-0133 46.1 µM -1.0896569259942 0.108054753193339 no 2996 0.13793214847341 4122 X1237 YHR072W ERG7
SGTC_1594 piperine 70.1 µM -1.09561909505491 0.106808798108719 no 2997 0.136622750860303 4159 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1870 st057514 26.5 µM -1.0962713923383 0.106673114812608 no 2998 0.136480012415824 4182 5393161
SGTC_2773 thioridazine 9.09 µM -1.09856057261317 0.106197930579083 no 2999 0.135979891617441 4198 5452 An antipsychotic.
SGTC_3161 9100388 49.47 µM -1.10100508349965 0.105692193281823 no 3000 0.135447222350116 4268 25236368
SGTC_3324 9138759 60.749 µM -1.10185237314582 0.10551730715745 no 3001 0.135262928507466 4246 45595710
SGTC_448 monastrol 171 µM -1.10499848214538 0.104869761076338 no 3002 0.134580123414813 4113 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_251 melphalan 456.522 µM -1.10630187163148 0.104602336293107 no 3003 0.134297940985831 4245 460612 A DNA alkylator.
SGTC_1230 0170-0365 3.77 µM -1.10745290464033 0.104366582510605 no 3004 0.134049081657649 4256 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1286 0929-0070 131 µM -1.10888403916391 0.104073995839101 no 3005 0.133740105044933 4267 1420408
SGTC_982 1491-0518 27.5 µM -1.11033119828053 0.103778738246779 no 3006 0.133428166986667 4120 3091256
SGTC_1604 st002052 72.4 µM -1.11195785641142 0.103447584163508 no 3007 0.133078135408025 4286 6254834 YHR062C RPP1
SGTC_1991 st073000 8.92 µM -1.11249791616208 0.103337808901213 no 3008 0.132962062812719 4269 4301969 YIL048W NEO1
SGTC_1381 2324-0066 62.1 µM -1.11715354904039 0.102394986871798 no 3009 0.131964338881308 4258 10885928
SGTC_2951 9072950 58.06 µM -1.1186436663821 0.102094545575591 no 3010 0.131646093415523 4174 16488155
SGTC_77 0828-0286 12.516 µM -1.1192661968262 0.101969219511314 no 3011 0.131513296111644 4114 745345
SGTC_208 k072-0098 12.366 µM -1.120010457453 0.10181953405171 no 3012 0.131354652895191 4185 5948901
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.1202585935285 0.101769664572991 no 3013 0.131301790719012 4341 16725076
SGTC_955 1216-0110 33 µM -1.12056678741148 0.101707749656641 no 3014 0.131236154461814 4196 3619719
SGTC_557 1315-0110 16.2 µM -1.12072767514807 0.101675438852125 no 3015 0.131201899096905 4219 6833801
SGTC_363 0455-0021 3.06 µM -1.12293614156691 0.101232671559736 no 3016 0.130732308272324 4177 4597466
SGTC_815 1582-0027 36.9 µM -1.12467698413812 0.100884647923965 no 3017 0.130362969089688 4253 3128206
SGTC_772 k072-0172 35.3 µM -1.12590571302633 0.100639530101241 no 3018 0.130102715457549 4262 5861980
SGTC_6 0844-0013 19.835 µM -1.12599352243097 0.100622029742341 no 3019 0.130084130569029 4353 1584900
SGTC_1153 4055-0057 267 µM -1.127105393465 0.100400626529611 no 3020 0.129848961633246 4273 882706
SGTC_1731 st035964 63 µM -1.12785342348665 0.100251873944572 no 3021 0.129690913492022 4144 6739575
SGTC_1609 st001574 46.4 µM -1.12832410904069 0.100158356328486 no 3022 0.129591532626575 4199 3960012
SGTC_447 ml7 120 µM -1.1284539292616 0.100132574356086 no 3023 0.129564131581476 4255 4216 Selective myosin light chain kinase inhibitor.
SGTC_3000 9075062 71.4286 µM -1.12878824452986 0.100066202482078 no 3024 0.129493586415708 4178 17057871
SGTC_2098 5376439 882.5 nM -1.1294005686963 0.0999447205896365 no 3025 0.129364446529303 4264 2844116
SGTC_2470 5664817 21.68 µM -1.13056484463875 0.0997140315293813 no 3026 0.129119145612703 4260 2859561
SGTC_619 1652-1634 108 µM -1.13089159794905 0.0996493587543823 no 3027 0.129050360055656 4186 5400454
SGTC_578 3460-0051 92 µM -1.13462621878172 0.0989123584869902 no 3028 0.128265981438237 4280 2876744
SGTC_647 0140-0236 81 µM -1.13587762724946 0.098666296359888 no 3029 0.128003891429008 4239 990837
SGTC_3167 9103034 49.47 µM -1.13852431319557 0.0981473598399902 no 3030 0.127450806217592 4306 5127859
SGTC_489 paxilline 115 µM -1.1388720377928 0.0980793302559091 no 3031 0.127378264959288 4221 105008 A toxic potassium channel blocker.
SGTC_2460 5552655 174.22 µM -1.13899263059511 0.0980557452925406 no 3032 0.127353113959815 4260 5401989
SGTC_1801 st050089 28.441 µM -1.13947710851465 0.0979610353015408 no 3033 0.127252105398143 4276 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_346 4513-0042 7.16 µM -1.13985844717976 0.097886535039941 no 3034 0.127172639497112 4195 2827372
SGTC_708 3448-5400 146 µM -1.14242084910459 0.0973870079417282 no 3035 0.126639564537918 4192 3462195
SGTC_318 1488-0629 67.2 µM -1.14313579110644 0.0972479679097268 no 3036 0.126491108072666 4283 3662576
SGTC_1547 harmine 94.2 µM -1.14418896983898 0.0970434138959228 no 3037 0.126272638249699 4188 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_721 1187-1332 279 µM -1.14493776336925 0.0968981714209407 no 3038 0.12611746967433 4193 25730
SGTC_2267 7931562 200 µM -1.14687636117779 0.0965228858106597 no 3039 0.125716361870057 4165 934880
SGTC_2502 avocadyne acetate 18.59 µM -1.14768181230611 0.0963672760569616 no 3040 0.125549971051121 4177 3952079
SGTC_2591 skatole 100 µM -1.14940595003831 0.0960347997745635 no 3041 0.125194313859536 4272 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2992 9074591 71.4286 µM -1.15511593414905 0.094939730532642 no 3042 0.124021476960968 4204 17741321
SGTC_804 1595-0054 20.9 µM -1.15555555695657 0.0948558019832909 no 3043 0.12393149778813 4192 761523 Stimulates phospholipase C.
SGTC_1928 4'-methoxychalcone 40.3 µM -1.15674592421101 0.0946288229765445 no 3044 0.123688090438723 4270 641818
SGTC_1225 1216-0074 20.6 µM -1.16173654088292 0.0936815701449237 no 3045 0.122671249004519 4269 4241466
SGTC_823 0417-1665 178 µM -1.1626405288598 0.0935107386464215 no 3046 0.122487689949061 4246 3429856
SGTC_1667 st014849 34.6 µM -1.16592067359158 0.0928928038847032 no 3047 0.121823259774515 4319 5348460
SGTC_1077 5-fluorocytosine 377 nM -1.16705758635645 0.092679331039394 no 3048 0.121593557317123 4310 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1441 4106-0040 13 µM -1.16730920435885 0.0926321349678678 no 3049 0.121542761449641 4260 2904180
SGTC_924 2046-0044 21.3 µM -1.16868308511406 0.0923747492092397 no 3050 0.121265669699083 4233 3623589
SGTC_2001 4023502 57.655 µM -1.16896737371855 0.0923215561228205 no 3051 0.12120838834313 4288 108941 YCR052W RSC6
SGTC_336 4111-0029 111 µM -1.16909389864742 0.0922978894030747 no 3052 0.121182900935602 4267 3131175
SGTC_393 acivicin 6.25 µM -1.16965803178797 0.0921924219066603 no 3053 0.121069306822223 4118 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_55 0767-0285 6.563 µM -1.16966199640948 0.092191681016766 no 3054 0.12106850876934 4176 3116166
SGTC_2247 cerulenin 830 nM -1.17122413142546 0.0919000994271405 no 3055 0.120754348965452 4319 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1900 st060200 72.8 µM -1.17150085532163 0.0918485185921707 no 3056 0.120698757112166 4248 688945
SGTC_2331 7980721 200 µM -1.17554943374895 0.0910963210549603 no 3057 0.119887486086876 4217 2981221
SGTC_1446 4239-0190 62 µM -1.17631160780268 0.0909552269122018 no 3058 0.119735189457559 4279 1340085
SGTC_1252 0493-0875 34.8 µM -1.17710596274774 0.0908083480186234 no 3059 0.119576607730324 4240 3960963
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.17775990559327 0.0906875639363665 no 3060 0.119446168523264 4241 364106
SGTC_2486 5283202 22.39 µM -1.17846262384734 0.0905579039249742 no 3061 0.119306112230404 4307 1377751
SGTC_2222 6885208 172.143 µM -1.18490111840808 0.0893763247763554 no 3062 0.118028272581067 4241 609514
SGTC_1963 st076565 50.3 µM -1.19049309287012 0.0883594359986861 no 3063 0.116926321595006 4295 4914280
SGTC_2558 carylophyllene oxide 100 µM -1.1910831847879 0.0882526339765787 no 3064 0.11681046518325 4400 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1511 0906-3109 28.5 µM -1.19157344496071 0.088163973921392 no 3065 0.11671427126756 4279 2882180
SGTC_572 0960-0087 17.7 µM -1.19286305239844 0.0879310746725082 no 3066 0.116461505697414 4254 6796365
SGTC_2242 6630449 61.2675 µM -1.19655574698758 0.0872667232046781 no 3067 0.115739878869644 4329 691249 YDR170C SEC7
SGTC_2168 5727979 200 µM -1.19874912458097 0.0868738914576012 no 3068 0.115312755116947 4194 695210
SGTC_1341 1486-1360 280 µM -1.19930877839289 0.0867738698962379 no 3069 0.115203951491192 4273 3976547
SGTC_2450 5739737 12.93 µM -1.2049320787059 0.0857736431902878 no 3070 0.114114761789638 4307 2262825
SGTC_765 1319-0117 244 µM -1.20554305956982 0.0856654888376669 no 3071 0.113996862790999 4267 3487746 YGL099W LSG1
SGTC_872 0588-0139 234 µM -1.20640403591643 0.0855132542500281 no 3072 0.113830870322979 4243 2047100
SGTC_2442 5158906 48.48 µM -1.20658821809457 0.0854807141745348 no 3073 0.113795383182828 4294 1893835
SGTC_1348 1493-0373 93.8 µM -1.20935241668997 0.0849934674327703 no 3074 0.113263740559915 4311 3010129
SGTC_914 3820-6779 408 µM -1.21192601829922 0.084541691514182 no 3075 0.112770350755942 4243 2893481
SGTC_1154 4088-0362 150 µM -1.21251926658855 0.084437807297373 no 3076 0.112656836024834 4308 6618304
SGTC_2513 baicalein 25.65 µM -1.21509041880533 0.0839886774927963 no 3077 0.112165803724762 4291 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2789 5281112 71.43 µM -1.21898471704978 0.0833118394588219 no 3078 0.11142499658311 4301 765948
SGTC_1613 st002381 52.1 µM -1.22030510066534 0.0830832870189185 no 3079 0.111174618466527 4291 551167
SGTC_1926 methyl fluorone black 53.6 µM -1.2220493123533 0.0827820951331999 no 3080 0.110844489752132 3955 72721 Reacts with homocysteine.
SGTC_2484 5809818 12.04 µM -1.22472050137804 0.0823224256706246 no 3081 0.110340273484153 4264 2870548
SGTC_1002 4049-0206 172 µM -1.22642457411597 0.0820301875043283 no 3082 0.1100194715523 4269 4662749
SGTC_3350 9150499 3.57 µM -1.22645272039818 0.0820253671574452 no 3083 0.110014178469353 4312 4910996 YPR165W RHO1
SGTC_2680 butyl paraben 22.24 µM -1.22916989280407 0.0815610269046217 no 3084 0.109504057249974 4410 7184 An antifungal and steroid mimetic.
SGTC_2623 humulene 100 µM -1.22927296176937 0.0815434524473799 no 3085 0.109484740605377 4307 6187145 An anti-inflammatory.
SGTC_1816 st051957 91.6 µM -1.23051997276721 0.0813310487905829 no 3086 0.109251226238175 4297 674121
SGTC_1786 berberine 21.6 µM -1.23249459359359 0.080995565259885 no 3087 0.108882192478783 4215 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_552 k242-0005 476 µM -1.23350266014081 0.080824700309901 no 3088 0.108694142429419 4383 4088318
SGTC_9 0092-0002 10.449 µM -1.23373251233285 0.0807857790224307 no 3089 0.10865129730944 4317 759368
SGTC_2047 4141938 200 µM -1.23558734537734 0.0804722145137465 no 3090 0.108305995467041 4324 3807862
SGTC_396 dithiazanine 1.25 µM -1.23577439935868 0.0804406436448006 no 3091 0.108271216767965 4304 10578 An antihelmenthic.
SGTC_2904 7225135 42.03 µM -1.23587742384797 0.0804232592245028 no 3092 0.108252064994026 4391 4446116
SGTC_2404 5161160 200 µM -1.23712026436839 0.0802137651104983 no 3093 0.108021218817503 4261 2831543
SGTC_3079 9117512 49.47 µM -1.23848190094848 0.0799847204075591 no 3094 0.107768714494148 4385 7185044
SGTC_720 r052-1644 49.9 µM -1.24118814814982 0.0795309636168322 no 3095 0.107268126025196 4336 1422863 YOR257W CDC31
SGTC_1308 1187-1617 41.4 µM -1.24143250960093 0.079490087582599 no 3096 0.107223007889478 4342 2882570
SGTC_677 0929-0063 136 µM -1.24245157570017 0.0793197927203474 no 3097 0.107034998224773 4334 1539583
SGTC_1152 3909-8331 15.9 µM -1.24456689060893 0.0789671868943213 no 3098 0.106645498586893 4285 16001939
SGTC_2521 angolensin 13.4 µM -1.24551684329762 0.0788092243452404 no 3099 0.106470914055626 4367 821428 A flavenoid.
SGTC_1770 st043884 66.3 µM -1.24598932872502 0.0787307464772303 no 3100 0.106384156457517 4326 670149
SGTC_1168 k815-0004 80.5 µM -1.24636987989831 0.0786675815738433 no 3101 0.106314316917527 4298 642433
SGTC_1839 st053978 48 µM -1.24750077258066 0.0784800996204664 no 3102 0.106106968568033 4342 3788398
SGTC_1914 st062367 72.6 µM -1.24868907671126 0.0782834650271943 no 3103 0.105889408823897 4326 978205
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.25091463760737 0.0779161958846946 no 3104 0.105482811429593 4311 688667
SGTC_2810 7959871 45.46 µM -1.25951394230519 0.0765093904294026 no 3105 0.103922378761366 4302 2974535
SGTC_3198 9112019 49.47 µM -1.26231490510576 0.0760553627834893 no 3106 0.103417747714456 4385 45595555
SGTC_1986 st071812 45 µM -1.26393816619532 0.0757931775135959 no 3107 0.103126110786058 4286 11838594
SGTC_2465 5809242 33.21 µM -1.27108961847293 0.0746462832226608 no 3108 0.101848384093346 4392 2731748
SGTC_707 0865-0008 204 µM -1.27237937164947 0.0744408597786508 no 3109 0.101619179886386 4383 723043
SGTC_3008 9078912 71.4286 µM -1.27282504422197 0.0743699763921793 no 3110 0.101540066046839 4362 16648731
SGTC_2283 7944793 200 µM -1.27498501751468 0.0740271666530693 no 3111 0.101157272535025 4357 2970533
SGTC_1915 st067105 30.6 µM -1.27508722789473 0.0740109747914923 no 3112 0.101139184762686 4283 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2234 tolnaftate 200 µM -1.27626673866103 0.073824315973385 no 3113 0.100930621868402 4439 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_304 1310-0298 97 µM -1.27783580066737 0.0735765681810565 no 3114 0.100653664156357 4119 1550234
SGTC_1063 disulfiram 1.84 µM -1.27854694099567 0.073464491907483 no 3115 0.100528322323501 4376 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2459 5811157 9.22 µM -1.27979135397799 0.0732686856335919 no 3116 0.100309262720748 4303 2870684 YBR192W RIM2
SGTC_314 1671-0008 2.74 µM -1.28148425667882 0.0730029515949418 no 3117 0.10001181310315 4242 3913060
SGTC_3228 9131799 49.47 µM -1.28331040648084 0.0727171295173943 no 3118 0.0996916741294044 4380 17015818
SGTC_544 k015-0020 52.4 µM -1.28378406041968 0.0726431351276061 no 3119 0.0996087611438718 4362 3008304
SGTC_2858 9025781 8.96 µM -1.28783883942883 0.0720120539403701 no 3120 0.0989010345596194 4216 4894980 YPL153C RAD53
SGTC_139 0099-0334 718.624 µM -1.28859809701364 0.0718943525864559 no 3121 0.0987689226761718 4379 97690
SGTC_233 rapamycin 362 pM -1.29008598019297 0.0716641263897467 no 3122 0.0985104035228115 4338 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1781 st038725 66.3 µM -1.29172874547178 0.0714105920834228 no 3123 0.0982255494914193 4355 4270275 YIL048W NEO1
SGTC_1695 st026914 34.495 µM -1.29236550192956 0.0713125043428023 no 3124 0.0981152989032958 4346 3289191
SGTC_1065 prochlorperazine maleate 2.48 µM -1.29348642782071 0.0711400851178402 no 3125 0.0979214375872009 4396 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2173 5763948 167 µM -1.29388459719193 0.0710789163791947 no 3126 0.097852642809318 4339 2867177
SGTC_7 0192-1582 4.227 µM -1.2977058406932 0.0704939303037585 no 3127 0.0971942179355486 4415 252616
SGTC_1124 fisetin 1.16336 µM -1.29867777791479 0.0703457305251129 no 3128 0.0970272667074532 4366 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_298 1391-0729 10 µM -1.30053344272227 0.0700634465486836 no 3129 0.0967091009515107 4299 3237558
SGTC_2383 9036125 200 µM -1.30142754057866 0.0699277477342483 no 3130 0.0965560759068994 4299 79580
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.30458923654613 0.0694495131981955 no 3131 0.0960163776562423 4447 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.30505294825526 0.0693795850049228 no 3132 0.0959374094377383 4396 165521
SGTC_908 3448-7491 47.7 µM -1.30625897579865 0.0691979687810942 no 3133 0.0957322515268613 4382 1203031
SGTC_1706 st031321 9.9705 µM -1.30642564572232 0.0691728987185312 no 3134 0.0957039246319738 4385 6103185
SGTC_1473 k844-0725 134 µM -1.30652354676383 0.0691581759579762 no 3135 0.0956872884373666 4407 54682906
SGTC_2036 5160441 105 µM -1.30810814501054 0.0689202132502434 no 3136 0.0954183156095669 4344 134534 YIL048W NEO1
SGTC_197 4544-0043 41.561 µM -1.30904449728764 0.0687798960770073 no 3137 0.0952596391523547 4384 896523
SGTC_1761 st044296 37 µM -1.31135647461348 0.0684343778913512 no 3138 0.0948686783159627 4379 1826700
SGTC_3172 9105863 49.47 µM -1.31146415575991 0.0684183179593315 no 3139 0.0948504980362881 4457 2348785
SGTC_2120 5538279 151.968 µM -1.31520583682729 0.0678620749989603 no 3140 0.0942203670225619 4338 2058197
SGTC_2395 5646831 180.19 µM -1.31721041005127 0.0675655128377976 no 3141 0.0938840527228535 4379 6808628
SGTC_749 1000-0129 128 µM -1.31866706797679 0.0673506397674561 no 3142 0.0936402205260543 4420 708470
SGTC_349 k015-0014 24 µM -1.31888180723722 0.0673190080876045 no 3143 0.0936043145764274 4388 2196908
SGTC_3035 9091303 49.47 µM -1.32039103614293 0.0670970184373754 no 3144 0.0933522474226278 4453 25237002
SGTC_785 1270-0111 65.3 µM -1.32771188691051 0.0660282325966091 no 3145 0.0921366525567894 4309 6741994
SGTC_1873 rapamycin 2 nM -1.32771461695131 0.0660278365073878 no 3146 0.0921362014418944 4332 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1253 0550-0034 176 µM -1.33861803929275 0.0644605436044413 no 3147 0.0903475252219865 4414 5969915
SGTC_303 1348-1668 34.2 µM -1.34037464406234 0.0642107694765427 no 3148 0.0900617874637493 4401 5380509
SGTC_378 3970-0959 8.33 µM -1.34365297855811 0.0637466312594048 no 3149 0.0895303146282456 4410 6615653
SGTC_460 trequinsin 123 µM -1.34840244357681 0.0630788487426431 no 3150 0.088764489238255 4485 5537 A vasodilator.
SGTC_2353 9059630 146.67 µM -1.3543155991136 0.0622550783702715 no 3151 0.0878178557750124 4441 4779114
SGTC_2301 7769476 200 µM -1.35733327747895 0.0618379273723976 no 3152 0.0873376691201314 4392 977820
SGTC_1865 st057639 52.2 µM -1.35964716044681 0.0615195464384855 no 3153 0.0869708033072604 4396 688818
SGTC_2418 pentamidine 31.67 µM -1.35997763293595 0.0614741794279976 no 3154 0.086918501024933 4359 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1410 3909-8106 77.9 µM -1.36001483871554 0.061469073484008 no 3155 0.08691261411812 4460 1039210
SGTC_2696 st077691 74.316 µM -1.3621054494001 0.0611826999054914 no 3156 0.0865823043980328 4433 757133
SGTC_2203 7227154 166.4 µM -1.36347183313768 0.0609960956386395 no 3157 0.0863669278215794 4438 896304
SGTC_2031 5180455 200 µM -1.36376286741366 0.0609564072081897 no 3158 0.0863211052692921 4401 29949
SGTC_1978 st071761 42 µM -1.36622514504196 0.0606214331440684 no 3159 0.0859341537422434 4429 5147680
SGTC_10 0279-0212 42.575 µM -1.37515640248114 0.0594184755907138 no 3160 0.084541480655233 4418 39851 YBR002C RER2
SGTC_681 1642-0006 26.6 µM -1.37558986323201 0.0593605720513601 no 3161 0.0844743233908525 4431 4446530
SGTC_1684 st024538 14.6195 µM -1.3779773697935 0.0590424312566749 no 3162 0.0841051376290958 4382 6732859
SGTC_2706 st078239 82.5 µM -1.37842801468302 0.0589825321107018 no 3163 0.0840355894463939 4414 15434492
SGTC_134 0269-0018 6.916 µM -1.38062179462564 0.0586916183538076 no 3164 0.0836976392614528 4376 4378915
SGTC_3258 9138477 49.47 µM -1.38356073881565 0.0583036560260422 no 3165 0.0832464985289099 4460 4970355
SGTC_1990 st072050 59.8 µM -1.38767823947917 0.057763507007141 no 3166 0.0826175225570101 4412 17233948
SGTC_1218 1348-1416 30.7 µM -1.39019089038089 0.0574358261591658 no 3167 0.0822354594833246 4391 6787668
SGTC_2202 7226349 200 µM -1.39229351218399 0.0571627436229792 no 3168 0.0819167676709176 4416 844334
SGTC_354 2783-3500 4.88 µM -1.39525096511652 0.0567803689241731 no 3169 0.0814700865496449 4425 6740761
SGTC_821 1114-0266 29.2 µM -1.39614339410184 0.0566653816290131 no 3170 0.0813356593034942 4457 3123235
SGTC_392 N-ethylmaleimide 8.33 µM -1.39985160434215 0.0561895514855782 no 3171 0.0807788804476431 4385 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1722 st034304 3.6505 µM -1.40027114650407 0.0561359156454882 no 3172 0.0807160688600426 4391 4036148 YLR033W RSC58
SGTC_2044 5102272 200 µM -1.40444044049755 0.0556050891425022 no 3173 0.0800938678079076 4431 592666
SGTC_14 0354-0009 295 µM -1.4054795646616 0.0554734085674596 no 3174 0.0799393609174823 4529 1713507
SGTC_1466 k213-0079 57.5 µM -1.40981215149666 0.0549270230268783 no 3175 0.0792975787984354 4402 3657981
SGTC_1896 st058441 89 µM -1.41338678616688 0.0544794329218302 no 3176 0.0787710143544409 4456 688759
SGTC_1156 4092-0367 4.88 µM -1.41392209336839 0.0544126546421406 no 3177 0.0786923891093914 4488 1357585
SGTC_2813 7971799 71.43 µM -1.41577249235084 0.0541823204618479 no 3178 0.0784210629222493 4445 2234054
SGTC_322 k048-0136 19.3 µM -1.41640320766776 0.0541039867636341 no 3179 0.0783287426563505 4493 6823282
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.41674422962159 0.0540616698047709 no 3180 0.0782788602791812 4448 6708561
SGTC_661 1304-0007 33.6 µM -1.42035647150959 0.053615038265057 no 3181 0.0777519641932046 4461 3117130
SGTC_1909 st060837 51.5 µM -1.42374031647821 0.0531993029832828 no 3182 0.0772608291909449 4395 678937
SGTC_1728 st035614 33.7865 µM -1.42917954243119 0.0525364059166384 no 3183 0.0764763180143136 4402 15945546
SGTC_2614 arthonioic acid 13.39 µM -1.42962513485748 0.0524823918940082 no 3184 0.0764123188104034 4316 6710684
SGTC_2018 5133068 143 µM -1.433362842647 0.0520310466902324 no 3185 0.0758770857014786 4419 785362
SGTC_1457 k015-0032 57.3 µM -1.43363067789073 0.0519988231364782 no 3186 0.0758388420711757 4435 4302660
SGTC_931 2812-0076 566 µM -1.4337237361002 0.0519876309128012 no 3187 0.0758255579223634 4374 3450959
SGTC_2694 st077685 81.9 µM -1.43377436563507 0.051981542441254 no 3188 0.0758183312520279 4372 2838096
SGTC_481 bay k-8644 50 µM -1.43562787561961 0.0517590377380308 no 3189 0.0755541291429427 4421 2303 A calcium channel antagonist.
SGTC_2171 5739187 198.077 µM -1.43582309824876 0.0517356463606371 no 3190 0.0755263427003054 4413 2262761
SGTC_525 k781-2675 26.7 µM -1.4428315240734 0.0509014555035268 no 3191 0.0745339682569462 4410 3651118 YDL195W SEC31
SGTC_655 k060-0012 42 µM -1.44630382806965 0.0504921435010451 no 3192 0.0740460012690281 4456 5994525
SGTC_337 1315-0038 354 µM -1.44988714420278 0.0500724992172029 no 3193 0.0735449964449084 4443 1626437
SGTC_2251 lansoprazole 556 µM -1.46004440504945 0.0488980759985516 no 3194 0.0721389351754697 4433 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1440 4100-1550 40 µM -1.46039918898032 0.048857455722619 no 3195 0.0720901977812824 4499 742806
SGTC_2826 7992541 19.48 µM -1.46103720664846 0.0487844750185618 no 3196 0.0720026155064576 4478 2985066
SGTC_2293 7624732 200 µM -1.46352721214119 0.0485004848031063 no 3197 0.0716615865717257 4372 894453
SGTC_3196 9111891 49.47 µM -1.46779512745649 0.0480167965451206 no 3198 0.0710799407106957 4461 18891510
SGTC_2962 9082311 13.18 µM -1.46828532179189 0.0479614902451781 no 3199 0.0710133681598482 4443 16459453
SGTC_1394 3474-0001 65.7 µM -1.47515148798589 0.0471921599555355 no 3200 0.0700859102580434 4464 5017666 YIL048W NEO1
SGTC_1206 3978-0017 132 µM -1.47551216018107 0.0471520229293417 no 3201 0.0700374507299721 4521 3873677
SGTC_2394 5221648 200 µM -1.47693148266391 0.0469943407834483 no 3202 0.0698470023770145 4504 788586
SGTC_2677 mitomycin C 100 µM -1.47736245336597 0.0469465451083773 no 3203 0.0697892525701806 4559 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1274 0865-0114 173 µM -1.48060805866763 0.0465878508467423 no 3204 0.0693555233426967 4470 870624
SGTC_274 sirtinol 40.1 µM -1.48342882979586 0.0462778972850833 no 3205 0.068980256217894 4527 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2414 st077232 92.9 µM -1.48438121850723 0.0461736210599787 no 3206 0.0688539072438835 4423 729801
SGTC_2853 9015042 58.44 µM -1.48567008741092 0.0460328044790366 no 3207 0.0686832032120168 4415 6457456
SGTC_1017 4239-0030 168 µM -1.48737775488296 0.0458467632458087 no 3208 0.0684575343761484 4495 1149593
SGTC_2961 9083290 32.55 µM -1.48853136546341 0.0457214258577969 no 3209 0.0683054083820993 4449 17741490
SGTC_2062 5245942 200 µM -1.49098254487172 0.0454560246538777 no 3210 0.0679830388643701 4517 1376160
SGTC_906 1165-0455 526 µM -1.4958037161193 0.0449376282841683 no 3211 0.0673524063466538 4471 3252859
SGTC_3227 9130768 49.47 µM -1.49848257571804 0.0446516472019684 no 3212 0.0670039581758322 4580 17720899
SGTC_995 3931-2021 34.6 µM -1.49905696413142 0.0445905197394705 no 3213 0.0669294274164238 4506 730143
SGTC_3026 9090633 49.47 µM -1.50110805798122 0.0443727885216912 no 3214 0.0666638074921015 4498 25236842
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.50291158646078 0.0441820459021347 no 3215 0.0664309223975503 4576 4620898
SGTC_1438 4092-1045 4 µM -1.50318022641214 0.0441536909686528 no 3216 0.0663962875619648 4505 1351342
SGTC_215 1287-0124 461.5 µM -1.50374823684818 0.0440937857981094 no 3217 0.0663231019438579 4520 5560863
SGTC_136 0097-0015 404.482 µM -1.50484175597614 0.043978642423415 no 3218 0.0661823827820466 4486 4861337
SGTC_1951 sophoraflavanone G 9.2 µM -1.51298038838999 0.0431292749127452 no 3219 0.0651423202518523 4440 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1465 k213-0056 144 µM -1.51661376325746 0.0427543894228821 no 3220 0.0646821142131882 4415 24048857 YMR208W ERG12
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.51775877545525 0.0426367963166305 no 3221 0.0645376105267399 4543 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2481 5478948 45.16 µM -1.52301463818025 0.0421003685044197 no 3222 0.0638775216093006 4504 77792
SGTC_140 0062-0056 502.533 µM -1.52508396348763 0.0418906717941562 no 3223 0.0636190782746052 4417 3758964
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.52954208709067 0.0414417775799546 no 3224 0.0630650568982459 4445 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_342 k048-0088 23.3 µM -1.52984242040116 0.0414116773202303 no 3225 0.0630278693058042 4504 6820570
SGTC_560 2332-1943 155 µM -1.54341091896385 0.0400701810542025 no 3226 0.0613655530386439 4511 21177716
SGTC_1327 1436-0082 2.18 µM -1.54778934031039 0.0396449058540642 no 3227 0.0608365118918434 4543 15992205
SGTC_496 calpeptin 138 µM -1.55072855343544 0.039361485048671 no 3228 0.0604833743886511 4507 73364 A calpain inhibitor.
SGTC_2146 5545642 200 µM -1.55159099984737 0.0392786350961591 no 3229 0.0603800590140093 4473 825326
SGTC_2095 5432005 200 µM -1.55766241637118 0.0386993993740098 no 3230 0.0596566471181623 4545 783734
SGTC_302 1094-0063 18.9 µM -1.56025006875811 0.0384546518892293 no 3231 0.0593503989096517 4522 5440289
SGTC_528 3492-0019 172 µM -1.56761679086349 0.0377647880722925 no 3232 0.0584852955642941 4525 2869262
SGTC_3051 9093778 49.47 µM -1.5787110614102 0.0367449460566136 no 3233 0.0572011732395298 4630 17217378
SGTC_2112 5488546 200 µM -1.59106913130892 0.0356355642598551 no 3234 0.0557970093048532 4501 600757
SGTC_2587 piperic acid 92.2 µM -1.59273108058571 0.0354884877518797 no 3235 0.0556102659714747 4477 5370536
SGTC_3239 9133757 49.47 µM -1.59330609746001 0.0354377168704797 no 3236 0.0555457697421206 4607 17036923
SGTC_428 3448-4153 16.5 µM -1.59353787965542 0.0354172686052277 no 3237 0.0555197888130591 4499 3834874
SGTC_1777 st045864 34.765 µM -1.59392197260684 0.0353834044983397 no 3238 0.0554767561892263 4560 4691462
SGTC_980 1473-0395 201 µM -1.59411916392408 0.0353660291608622 no 3239 0.0554546736968527 4467 768876
SGTC_615 k087-0205 167 µM -1.59725567284567 0.0350905980661935 no 3240 0.0551043636592942 4557 9642773
SGTC_1937 st074714 47.2 µM -1.5997706084577 0.0348710238049018 no 3241 0.0548247406706119 4482 17250970
SGTC_1367 1812-0510 76.9 µM -1.60887779268111 0.034085311466835 no 3242 0.0538215331247294 4597 1142582 YDR527W RBA50
SGTC_1709 st033179 39.1045 µM -1.61378663127253 0.0336678809949727 no 3243 0.0532868576495899 4557 573381
SGTC_2655 perillic acid 100 µM -1.61499117080186 0.0335660965301278 no 3244 0.0531563034528079 4593 5702197 An apoptosis inducer.
SGTC_1484 3473-2379 286 µM -1.61514778893706 0.0335528808107636 no 3245 0.0531393470189779 4655 671917
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.62248885144599 0.0329382177468463 no 3246 0.0523493591450022 4577 16486 A toxic proline analog.
SGTC_1712 st032288 53.4 µM -1.62363151337764 0.0328433832173064 no 3247 0.0522272377946912 4347 2883011
SGTC_2990 9074105 71.4286 µM -1.62559751501855 0.0326807429454854 no 3248 0.0520176520985973 4495 6502001
SGTC_582 0987-0078 156 µM -1.62789463053855 0.0324915527417363 no 3249 0.051773615080032 4601 1625765
SGTC_1905 st060207 84.5 µM -1.63344010211717 0.0320385493860583 no 3250 0.0511882343215311 4552 1948547
SGTC_2652 actinonin 100 µM -1.63414236705496 0.0319815559792286 no 3251 0.0511144803135631 4612 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1349 flufenamic acid 69 µM -1.64208783259489 0.0313425426106067 no 3252 0.0502859014444906 4511 3371 A non-steroidal anti-inflammatory.
SGTC_2440 5628896 157.78 µM -1.64849537173729 0.0308349397884171 no 3253 0.0496255298319388 4548 5522048
SGTC_3192 9110362 49.47 µM -1.65262136781648 0.0305116960061062 no 3254 0.0492039732671366 4553 16649480
SGTC_1102 cgs 12066b 26.1 µM -1.6529229073465 0.0304881829079729 no 3255 0.0491732771943937 4594 6438352 A 5-HT1B full agonist.
SGTC_947 3447-0010 211 µM -1.65365714791701 0.0304309919205435 no 3256 0.0490985970482461 4521 748350
SGTC_347 4534-1311 26.2 µM -1.65428197043626 0.0303823936796894 no 3257 0.0490351172648246 4591 2862016
SGTC_1352 1496-0991 99 µM -1.67020269244309 0.0291656248899 no 3258 0.0474396337510256 4587 3000039
SGTC_329 k048-0121 21.3 µM -1.67023834313315 0.0291629463344288 no 3259 0.0474361082883571 4580 6832902
SGTC_1439 4092-1168 46 µM -1.67083880194096 0.0291178625565154 no 3260 0.0473767610270492 4596 2886240
SGTC_3331 9141060 1.957 µM -1.6783533908092 0.0285585312343889 no 3261 0.0466390654357837 4536 4906567 YPR165W RHO1
SGTC_2385 9074692 200 µM -1.68097151501003 0.0283657686079823 no 3262 0.0463842237797483 4586 17046906
SGTC_1833 st055984 71 µM -1.68104208793843 0.0283605876118963 no 3263 0.0463773698912559 4614 676288
SGTC_386 1509-0011 3.07 µM -1.70178400565945 0.0268716166129422 no 3264 0.0443979329326142 4596 3107280
SGTC_231 b-estradiol 524 µM -1.70311691567402 0.0267782074813938 no 3265 0.0442730954647982 4607 450 A steroid.
SGTC_675 1309-0189 238 µM -1.73144960049728 0.024855933877909 no 3266 0.0416858032841599 4607 4246530
SGTC_250 brefeldin a 552.239 µM -1.73418480453976 0.0246766442101362 no 3267 0.0414426491160914 4560 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_385 1494-0393 12.4 µM -1.74307642373019 0.0241012883142157 no 3268 0.0406601331139195 4566 3090647
SGTC_3256 9138902 49.47 µM -1.74809005454343 0.0237818661778344 no 3269 0.0402242174325763 4710 17228773
SGTC_2673 kobusone 100 µM -1.75493963985349 0.0233512330198775 no 3270 0.0396348164308731 4708 6710676 An epoxy ketone and protein crosslinker.
SGTC_2423 st077119 87.2 µM -1.75810440790996 0.0231544916008831 no 3271 0.0393648729586685 4532 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_141 0443-0274 32.331 µM -1.76000541963476 0.0230369853448226 no 3272 0.0392034438327593 4547 1627241
SGTC_870 0573-2213 57.6 µM -1.76322722096354 0.0228389846905853 no 3273 0.0389310872299168 4608 3916321
SGTC_2969 9091408 28.7 µM -1.77194690075594 0.0223102829323304 no 3274 0.0382016859864698 4549 4286311
SGTC_2280 7785178 200 µM -1.77991660246752 0.0218361225311713 no 3275 0.037544805089661 4604 2954328
SGTC_2987 9018338 71.43 µM -1.78707329850861 0.0214176125865121 no 3276 0.0369628212337273 4625 5055682
SGTC_1574 spiramycin 23.7 µM -1.79642437151972 0.0208810158970414 no 3277 0.0362135253435854 4602 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_390 dec-rvkr-cmk 16.7 µM -1.79858889627043 0.020758443121893 no 3278 0.0360418675445542 4659 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1633 st005664 67.9 µM -1.80350363621517 0.0204823916839797 no 3279 0.0356545774466908 4612 2063822
SGTC_1387 3342-1166 1.8 µM -1.80467362572637 0.0204171359625304 no 3280 0.0355628846554122 4636 3418228
SGTC_2635 hydroquinidine 100 µM -1.81269957243552 0.0199742248934635 no 3281 0.0349390852398819 4572 442912 An experimental heart treatment.
SGTC_2956 9076196 2.52 µM -1.8168215364004 0.0197499407642956 no 3282 0.0346222220273045 4616 16423868
SGTC_2855 9016525 58.44 µM -1.82123125375658 0.0195123698943812 no 3283 0.0342858557425736 4581 43811474
SGTC_207 4185-0010 4.486 µM -1.82449146622037 0.0193382924518136 no 3284 0.0340389026594241 4658 3761753
SGTC_423 5-fluorouracil 457 µM -1.82591432864267 0.0192627340709428 no 3285 0.0339315837603638 4561 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3241 9133421 49.47 µM -1.82792956046857 0.0191561484888744 no 3286 0.0337800619640818 4711 17018221
SGTC_1385 3091-4834 14.1 µM -1.83444850090883 0.0188147895879769 no 3287 0.0332937228563296 4632 4072814
SGTC_1373 2887-0003 58.5 µM -1.84022750999368 0.0185165179374885 no 3288 0.0328674213709815 4606 776948
SGTC_2259 7964009 200 µM -1.8539366532053 0.017825014467629 no 3289 0.0318741116486078 4649 313134
SGTC_380 3970-0968 6 µM -1.85447219958996 0.0177984541373025 no 3290 0.0318358169306641 4561 2891601
SGTC_1396 3511-0007 98.6 µM -1.86055494620035 0.0174991433149244 no 3291 0.0314035261238312 4661 X1396
SGTC_3191 9110352 49.47 µM -1.88218093670666 0.0164695555648137 no 3292 0.0299057265344541 4613 17122424
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.89481078799203 0.0158925924116512 no 3293 0.029058736733279 4620 6857784
SGTC_820 1582-0060 59.9 µM -1.89772409895598 0.0157619925430858 no 3294 0.028866218132233 4675 3848840
SGTC_771 0250-0039 27.3 µM -1.90687782141239 0.0153576167433862 no 3295 0.028268205403443 4613 3005115
SGTC_2850 9015429 58.44 µM -1.90732508115349 0.0153380889267627 no 3296 0.0282392521372892 4653 6457570
SGTC_2367 9070478 135.38 µM -1.91414452139021 0.0150429759949456 no 3297 0.0278008460881394 4604 572802
SGTC_711 k292-0785 179 µM -1.91470764192422 0.0150188264137655 no 3298 0.027764899233469 4610 4146315
SGTC_3229 9132204 49.47 µM -1.92087445329227 0.0147565341944245 no 3299 0.0273737685839387 4738 17682924
SGTC_246 cycloheximide 667 µM -1.92816121698768 0.014451694303192 no 3300 0.0269175382553569 4644 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_3243 9134147 49.47 µM -1.93445467573372 0.0141927876265117 no 3301 0.0265286247922749 4738 24282180
SGTC_313 3474-0040 5.03 µM -1.94528087078574 0.0137567538774247 no 3302 0.025870591572642 4676 1043375 YIL048W NEO1
SGTC_631 k072-0230 41.5 µM -1.95024718522417 0.0135606292182954 no 3303 0.0255733321406761 4678 5773147
SGTC_309 k408-0051 1.48 µM -1.96576964658647 0.0129631131886064 no 3304 0.0246626127633816 4600 3640463
SGTC_2787 5284540 71.43 µM -1.97332322455156 0.0126806763132655 no 3305 0.0242293742727055 4662 736958
SGTC_748 act1.228 77.9 µM -1.97784129111551 0.012514298575701 no 3306 0.0239733068609247 4666 4421505 YNR035C ARC35
SGTC_414 piperonyl butoxide 100 µM -1.98806447812186 0.0121447921189814 no 3307 0.0234022796752338 4689 5794 A potent inhibitor of cytochrome P450.
SGTC_1290 0986-0249 10.2 µM -1.99097492815445 0.0120413418315168 no 3308 0.023241821842304 4578 53329
SGTC_900 1112-0045 141 µM -1.99331725392332 0.0119586409440213 no 3309 0.0231133591211518 4635 56211 YIL048W NEO1
SGTC_1165 k072-0275 30.3 µM -1.99411970447195 0.0119304222028538 no 3310 0.0230694871743442 4676 6153523 YGL055W OLE1
SGTC_678 1218-2179 85.9 µM -2.00276680012376 0.0116299869913473 no 3311 0.0226011624745637 4705 6820081 YOR116C RPO31
SGTC_1425 4048-4433 7.33 µM -2.01209055729142 0.0113134225197551 no 3312 0.0221051959433398 4738 23734946
SGTC_3023 9089636 49.47 µM -2.01352574996232 0.0112653653093044 no 3313 0.0220296744133039 4739 17249241
SGTC_3130 9127414 49.47 µM -2.0385330938499 0.0104560331861191 no 3314 0.0207483243076166 4709 1494646
SGTC_3022 9087993 49.47 µM -2.04848218719873 0.0101484165391284 no 3315 0.0202563878622062 4751 17173644
SGTC_752 1896-0090 130 µM -2.05709476074427 0.00988852970782278 no 3316 0.0198385557964421 4710 772567
SGTC_272 doxorubicin 8.13 µM -2.07747278673758 0.00929664039704613 no 3317 0.0188789721877909 4720 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1718 roemerine 11.9335 µM -2.09049235705366 0.00893492068403173 no 3318 0.0182867971216765 4336 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1171 0368-0077 21.4 µM -2.09430283358434 0.00883141476654349 no 3319 0.0181165060437365 4700 3239779
SGTC_1947 st076332 61.6 µM -2.09442979187896 0.00882798429938352 no 3320 0.0181108555948734 4599 24208416
SGTC_1173 0443-0020 122 µM -2.10490209989079 0.00854900921415603 no 3321 0.0176499154392491 4691 5331295
SGTC_2434 5670830 169.91 µM -2.118662858364 0.00819420878792638 no 3322 0.017059484677852 4709 1549830
SGTC_144 4161-2749 112.381 µM -2.13263592676994 0.00784723673644178 no 3323 0.0164773018765849 4724 797501 YMR168C CEP3
SGTC_1992 st073643 23.3 µM -2.14074827837083 0.00765178175946535 no 3324 0.0161471714722188 4716 3161292
SGTC_1180 1193-0155 285 µM -2.14153007561902 0.00763317388651938 no 3325 0.016115657894112 4740 2921347
SGTC_1904 st060225 78 µM -2.14413787797913 0.00757139230525339 no 3326 0.0160109204279889 4698 66595
SGTC_1415 3966-0071 78.1 µM -2.17703498138287 0.00682901874234264 no 3327 0.0147389787569311 4665 2893185
SGTC_3134 9127454 49.47 µM -2.1809148136805 0.00674584895505793 no 3328 0.0145948589098354 4712 24262820
SGTC_1573 oleylamine 1.06 µM -2.18976900612232 0.00655939036462241 no 3329 0.0142704967993413 4709 5356789 An amine of the fatty acid oleic acid.
SGTC_630 4356-0227 183 µM -2.19160877968969 0.00652122383404118 no 3330 0.0142038837248702 4693 779312
SGTC_1107 amlodipine 47 µM -2.19166096843826 0.00652014403717878 no 3331 0.0142019980294358 4313 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3036 9090181 49.47 µM -2.2389681742118 0.00560402949418913 no 3332 0.0125789935054198 4762 25236586
SGTC_2332 7982454 138.89 µM -2.25835002633457 0.00526299062665738 no 3333 0.0119619228493279 4679 2981748
SGTC_244 nsc-207895 1.295 µM -2.25932457626446 0.00524634082874502 no 3334 0.0119316011257219 4667 42640
SGTC_2446 5162541 200 µM -2.30626697736539 0.00449781645243635 no 3335 0.0105478595679642 4725 1549321
SGTC_2291 7917025 104.35 µM -2.31187663287508 0.00441507084500339 no 3336 0.0103922413890313 4680 2964612
SGTC_1287 0971-0001 34.6 µM -2.33304108953905 0.00411499267555716 no 3337 0.0098229944262633 4748 4665869
SGTC_1782 st039423 80.636 µM -2.33421158415709 0.00409894252509945 no 3338 0.00979232281631079 4735 2068169
SGTC_2979 9012552 45.46 µM -2.33576434915 0.00407773704165609 no 3339 0.00975176331764212 4739 17100905
SGTC_741 4582-0002 126 µM -2.35220145887937 0.00385921052401059 no 3340 0.00933133206431378 4762 2912688
SGTC_614 0462-0418 107 µM -2.45810008388419 0.00268584997515026 no 3341 0.00698371214265877 4625 5188303
SGTC_2016 5121758 140 µM -2.46858668312744 0.00258929610594956 no 3342 0.00678238969608165 4700 2795203
SGTC_1233 0325-0408 14.2 µM -2.48350386459196 0.00245734940342183 no 3343 0.00650484613874363 4775 12874
SGTC_3005 9076496 71.4286 µM -2.50153281035262 0.00230601203026898 no 3344 0.00618284918870727 4749 21368410
SGTC_1934 st074720 32.6 µM -2.5465128486233 0.00196454833476705 no 3345 0.00544026029895258 4721 17250992
SGTC_1326 1431-2094 10.8 µM -2.5497230062195 0.00194202958579131 no 3346 0.00539042683877043 4769 616278
SGTC_2427 5545055 42.75 µM -2.57288263081272 0.00178639252991415 no 3347 0.00504277017896337 4746 5372858
SGTC_2984 9022109 38.96 µM -2.5827602782409 0.00172353427039659 no 3348 0.00490066999380136 4767 6459207
SGTC_341 1486-1430 230 µM -2.61365029189043 0.00153973201613009 no 3349 0.0044790337520272 4752 2054753 YPL210C SRP72
SGTC_1328 1441-0025 69.2 µM -2.75358061125479 0.000910808291406903 yes 3350 0.00294736257349671 4790 4562601
SGTC_1943 st076331 65.2 µM -2.89908829851958 0.000514715549638793 yes 3351 0.00187124741280362 4770 24208415
SGTC_412 gemfibrozil 100 µM -2.91234401337273 0.000488023333443549 yes 3352 0.00179363659524618 4786 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2244 6635614 200 µM -3.00180856759249 0.000338814194843023 yes 3353 0.00134190444360721 4776 836499
SGTC_1766 st045414 44.774 µM -3.14734835157644 0.000183323582204839 yes 3354 0.000823792725530019 4792 253960
SGTC_613 3914-0030 117 µM -3.46128058147041 4.4667307023232e-05 yes 3355 0.000268806085202387 4734 1145395
SGTC_750 4073-0104 132 µM -4.85903293199089 1.92150750991245e-08 yes 3356 5.89802567663897e-07 4777 22330957