SGTCid condition conc unit SPC24|YMR117C.score SPC24|YMR117C.strain.pval SPC24|YMR117C.strain.significant SPC24|YMR117C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1060 3448-7350 82 µM 6.10465418143293 1.26499632173419e-13 yes 1 5.15117489436843e-10 8 570178
SGTC_2136 5328288 199.296 µM 5.5067162559694 2.00732989379269e-11 yes 2 1.82794397052604e-08 3 262395
SGTC_1030 k029-0042 36.7 µM 3.98690216533693 8.36803405582412e-07 yes 3 3.34708064173126e-05 3 6080581
SGTC_507 nimesulide 162 µM 3.60376786052925 7.38974917407292e-06 yes 4 0.000156818600625335 2 4495 A COX2 inhibitor.
SGTC_465 cgp-37157 41 µM 3.50705501552341 1.24060926910467e-05 yes 5 0.000226547730835187 2 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_443 clozapine 122 µM 3.48237678695179 1.41306507207469e-05 yes 6 0.000248491935138693 6 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_685 1278-0033 54.9 µM 3.46993168219333 1.50845291904685e-05 yes 7 0.00026029538078976 11 3590572
SGTC_1047 2043-3044 82 µM 3.4628526930446 1.56540954155784e-05 yes 8 0.000267240460611243 14 669592
SGTC_1587 estradiol valerate 56.1 µM 3.40830678214931 2.07807112220274e-05 yes 9 0.00032683679830868 6 13791 A steroid.
SGTC_2338 7999974 200 µM 3.40271513441968 2.13881580715639e-05 yes 10 0.000333599024241662 14 315925
SGTC_1333 1482-0047 286 µM 3.24841266436057 4.65788625210272e-05 yes 11 0.000580254143379455 12 3811116
SGTC_2547 epiafzelechin trimethyl ether 100 µM 3.18393374118151 6.38674908860495e-05 yes 12 0.000726441323568094 4 6708630 An antioxidant.
SGTC_505 gw-5074 63.9 µM 3.09710031307124 9.68361123398711e-05 yes 13 0.000977118655653275 17 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3009 9080819 71.4286 µM 3.09495839738173 9.78228096917191e-05 yes 14 0.000984202523845509 16 17027216
SGTC_3014 9081533 49.47 µM 3.04702957102342 0.000122533803212295 yes 15 0.00115557486040007 15 21367265
SGTC_2060 5238662 140 µM 3.0360316431673 0.000128976669692297 yes 16 0.00119857102813213 14 790130
SGTC_425 3825-7017 13.1 µM 2.94166032449623 0.000198870062482065 yes 17 0.0016322890163011 22 3397440
SGTC_1100 amiodarone 5.07 µM 2.8904495613294 0.000250288492403847 yes 18 0.00192345628925599 12 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2052 5265182 7.135 µM 2.86597612995446 0.000279015736690455 yes 19 0.00207862795423857 22 1239884
SGTC_245 methotrexate 289.6 µM 2.85494849160519 0.000292939029607311 yes 20 0.00215219046424268 27 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_352 k048-0007 5.11 µM 2.84957499686741 0.000299955423616926 yes 21 0.00218888417192458 30 6811911
SGTC_2696 st077691 74.316 µM 2.8075737493783 0.000360433851647742 yes 22 0.00249581243939129 30 757133
SGTC_1365 1672-3266 55.4 µM 2.70860456695223 0.000550467560225323 yes 23 0.00337834083353723 25 6415873
SGTC_2989 9073649 71.4286 µM 2.69623817344863 0.000579844501755568 yes 24 0.00350637521963886 33 21367202
SGTC_2583 asiatic acid 100 µM 2.67858853355746 0.000624287300040426 yes 25 0.00369665920548476 31 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2332 7982454 138.89 µM 2.65272915079139 0.00069510488253455 yes 26 0.00399219555226416 30 2981748
SGTC_998 3996-0085 177 µM 2.62776732694684 0.000770423121402431 yes 27 0.00429736402196308 15 715391
SGTC_231 b-estradiol 524 µM 2.59395727328764 0.000884445688383343 yes 28 0.00474391384803346 14 450 A steroid.
SGTC_2644 guaiazulene 100 µM 2.56629135508715 0.000989074254310125 yes 29 0.00513962228602863 11 3515 A coloring agent.
SGTC_831 k061-1017 217 µM 2.53206796768331 0.00113418781204929 no 30 0.00566960045807995 42 1240153
SGTC_1356 1502-0781 85.8 µM 2.52277250780698 0.00117683977747577 no 31 0.00582168487021097 22 567702
SGTC_643 k048-0106 28.4 µM 2.5208024074809 0.00118606606770608 no 32 0.00585437901783489 39 6763920
SGTC_321 4534-3890 65.3 µM 2.5173094172652 0.00120258724788188 no 33 0.00591274634595196 23 699746
SGTC_2564 betulinic acid 100 µM 2.51577828981918 0.00120989537797205 no 34 0.00593849352681746 34 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1191 1487-1166 10.6 µM 2.51337682974443 0.00122143954830724 no 35 0.0059790763454095 21 3955771
SGTC_742 0kpi-0133 140 µM 2.51337070813022 0.00122146910417373 no 36 0.00597918010937086 21 2728852
SGTC_1282 0886-0010 32.4 µM 2.5012363631788 0.00128135849576161 no 37 0.00618802744355372 47 2836211 YNL267W PIK1
SGTC_639 0833-0042 114 µM 2.4939686553489 0.00131850225419397 no 38 0.00631618495642513 32 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_3015 9080845 49.47 µM 2.48113980372835 0.00138647825819247 no 39 0.00654814983299171 19 5296973
SGTC_1339 1486-1321 22.7 µM 2.47060939598227 0.0014446512730135 no 40 0.00674415283560296 31 3469382
SGTC_2917 7979103 53.79 µM 2.44600291939927 0.00158936894387286 no 41 0.0072224915422427 30 2980565
SGTC_1152 3909-8331 15.9 µM 2.43120079449919 0.00168266893638381 no 42 0.00752443601693286 22 16001939
SGTC_2692 st077426 47.7 µM 2.37243220383187 0.00210435236661314 no 43 0.00883570293412419 42 25238571
SGTC_627 1391-0720 175 µM 2.37088769566765 0.00211662637418595 no 44 0.00887271105109594 37 997839
SGTC_495 decylubiquinone 155 µM 2.36029016598135 0.00220260980987427 no 45 0.00913032282084088 29 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_234 nsc-17383 10.7 µM 2.34959751364076 0.00229256175171628 no 46 0.00939686032574636 34 408974
SGTC_191 3914-0123 66.505 µM 2.34459361105035 0.00233578911153958 no 47 0.00952391414705367 32 3144412
SGTC_266 formosanin C 406 nM 2.33110263343977 0.00245603523211524 no 48 0.00987397423709279 54 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1121 fusaric acid 630.51 nM 2.25559137100687 0.00323847255484499 no 49 0.0120481170620385 28 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_641 4092-0595 30 µM 2.25292970359121 0.00326974949717221 no 50 0.012131790823066 49 786260
SGTC_2823 7987624 58.44 µM 2.25159241301537 0.00328556615531083 no 51 0.0121740204789624 60 2239440
SGTC_489 paxilline 115 µM 2.22586318732851 0.00360357570072273 no 52 0.0130116734090389 32 105008 A toxic potassium channel blocker.
SGTC_2281 7943571 200 µM 2.22555939746523 0.00360749008328165 no 53 0.0130218541961408 39 1244024
SGTC_2284 7945075 39.21 µM 2.21788511372839 0.00370764884479224 no 54 0.0132813333789476 34 1245402
SGTC_2354 9060492 162 µM 2.21175292975494 0.00378946651052429 no 55 0.013491870540729 28 6471895
SGTC_1606 st000094 49.2 µM 2.20426986376298 0.00389149864566406 no 56 0.0137526855093436 46 1242210
SGTC_1196 1588-0294 184 µM 2.15066179507792 0.00469732737381702 no 57 0.0157514519822926 35 6144269
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 2.13833649660113 0.00490244152726866 no 58 0.0162447212312446 35 688761
SGTC_2623 humulene 100 µM 2.13652363969267 0.00493327455327548 no 59 0.0163183781139229 29 6187145 An anti-inflammatory.
SGTC_1540 guanosine 70.6 µM 2.13623856012269 0.00493813886938265 no 60 0.0163299869636072 28 6802 Guanosine is a purine nucleoside
SGTC_705 1124-0212 310 µM 2.11210462828219 0.00536575499002514 no 61 0.0173387380585483 50 9554485
SGTC_2815 7968870 71.43 µM 2.10460432054051 0.00550519606961594 no 62 0.017662882614952 46 2977326 YHR190W ERG9
SGTC_2545 solidagenone 89.61 µM 2.10291868041738 0.00553697408431856 no 63 0.0177364392984177 17 6708572 An anti ulcer agent
SGTC_2550 chrysin dimethyl ether 71.87 µM 2.10074274722459 0.00557823609589748 no 64 0.017831777336544 17 88881 An O-methylated flavonoid and antioxidant.
SGTC_597 k018-0003 82.8 µM 2.09858691004469 0.00561938614087703 no 65 0.0179266656298903 36 6786234
SGTC_276 colchicine 750 µM 2.09562410577854 0.00567637911265415 no 66 0.0180577745514449 46 2833 A microtubule depolymerizer.
SGTC_2125 5246583 200 µM 2.08941891183519 0.00579740879617427 no 67 0.0183350151477838 44 835267
SGTC_2876 9059903 25.97 µM 2.05943552237612 0.00641506461162548 no 68 0.0197262678920125 40 6916095
SGTC_1418 3966-3099 2.4 µM 2.01964276310864 0.00732437035588802 no 69 0.0217102280366935 60 740335
SGTC_2764 methyldopa 94.69 µM 2.00472046197909 0.00769359238627109 no 70 0.0224964698740794 40 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1198 1612-1005 86.7 µM 2.00330121973646 0.00772954758479365 no 71 0.0225724833296048 61 6998509
SGTC_3340 9146634 11.102 µM 2.00192833201387 0.00776446907026192 no 72 0.0226462200089694 36 4907387
SGTC_374 0880-0231 82.3 µM 1.99867268774411 0.00784783685585386 no 73 0.0228218900018876 62 6833587
SGTC_1741 st038134 10.228 µM 1.9936624509702 0.00797767330885991 no 74 0.0230944777460846 45 1272587
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.98884529722275 0.00810428325658514 no 75 0.0233591406252201 35 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_991 3996-0057 64.7 µM 1.97627150968287 0.0084431176094775 no 76 0.0240620172877551 56 715343
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.96158339205993 0.00885462065380954 no 77 0.024905503699827 56 5024745
SGTC_279 1273-0055 2.93 µM 1.9516407053281 0.0091430553512416 no 78 0.0254904384601793 55 2847562
SGTC_2693 st077581 40.7 µM 1.94899878497097 0.00922106664430295 no 79 0.0256477849110691 41 25238761
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.94447881563684 0.00935588490803738 no 80 0.0259188688068859 50 616764
SGTC_760 0568-0725 82.9 µM 1.94071603409403 0.00946943044173585 no 81 0.0261463652174349 45 3916171
SGTC_761 k216-0224 480 µM 1.94055382970846 0.00947435209111814 no 82 0.0261562094590809 59 1340404
SGTC_1160 4092-0570 10.5 µM 1.93731861482853 0.00957298415116305 no 83 0.0263532040874912 58 4994975
SGTC_2967 9089538 49.85 µM 1.93424232919893 0.00966760225859702 no 84 0.0265416701057122 69 728216
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.9321543192249 0.00973228837609318 no 85 0.0266702307598362 62 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1125 tnp00248 1.32998 µM 1.92400012326883 0.00998853915301544 no 86 0.027177284008412 75 24207736
SGTC_459 nigericin 15.3 µM 1.91817265307152 0.0101752612183412 no 87 0.0275445612814718 70 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1305 1181-0477 144 µM 1.91312274029785 0.0103395243143683 no 88 0.0278661705973621 63 6252086
SGTC_2350 9023895 38.85 µM 1.91184861181618 0.0103813325122061 no 89 0.027947807271264 56 2997209
SGTC_1563 conessine 56.1 µM 1.91152009089697 0.0103921361939275 no 90 0.0279688887204028 33 441082 An anti-amoebic, histamine inhibitor.
SGTC_3024 9090631 49.47 µM 1.90867364868612 0.0104861548536918 no 91 0.0281521022830218 34 25236383
SGTC_3025 9087895 49.47 µM 1.90687948124807 0.0105457967403192 no 92 0.0282680979086658 48 17173641
SGTC_936 3005-4620 401 µM 1.89815915266219 0.0108399066085435 no 93 0.0288375599279138 58 777207
SGTC_2386 9075165 157.42 µM 1.89154556690301 0.011067698550784 no 94 0.0292757771445488 58 16452277
SGTC_213 1246-0773 967 nM 1.8909229620367 0.0110893558441316 no 95 0.0293173143715347 39 6251622
SGTC_3181 9108277 49.47 µM 1.87983143697134 0.0114813972975922 no 96 0.0300655272672481 69 17097298
SGTC_2975 9084847 53.72 µM 1.86694848785039 0.0119518209546167 no 97 0.0309543908631391 70 27211724
SGTC_1753 st043925 64 µM 1.86166240197912 0.0121496279092868 no 98 0.0313253456894471 58 670181
SGTC_883 0850-0245 24.6 µM 1.85507620232601 0.0124000508829368 no 99 0.031792672792371 78 6823229 YPR165W RHO1
SGTC_2537 larixol 68.93 µM 1.85105498065105 0.012555135234168 no 100 0.0320808219049426 74 6708759
SGTC_2820 7989630 71.43 µM 1.84619926023858 0.0127446388106467 no 101 0.0324316391722291 32 2984098
SGTC_305 1682-2595 20.8 µM 1.84565828994796 0.0127659036224035 no 102 0.0324709185379789 60 226033
SGTC_1257 0669-0121 16 µM 1.83631428723831 0.0131380772125195 no 103 0.0331555939646258 62 4307855
SGTC_618 k072-0232 33.2 µM 1.83315291009735 0.0132661008186447 no 104 0.0333899172630207 71 5872756 YGL099W LSG1
SGTC_751 0833-0568 350 µM 1.81827031217579 0.0138833676504416 no 105 0.0345114139955145 56 6954252
SGTC_135 0933-0004 26.348 µM 1.80307265234608 0.0145391034432368 no 106 0.035688402714154 67 21230617 YGL099W LSG1
SGTC_1262 0737-0114 49.6 µM 1.8024912599428 0.0145647095267566 no 107 0.0357340742853374 61 765919
SGTC_3347 9188721 44.724 µM 1.797827078421 0.0147715407997861 no 108 0.0361022074111162 67 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1788 fluconazole 20 µM 1.78297357953319 0.015447130145231 no 109 0.0372953021177385 75 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1376 2910-0861 41.3 µM 1.77883777202705 0.0156398981938988 no 110 0.0376331812975979 63 1112859
SGTC_2722 naftopidil 47.16 µM 1.77763819550276 0.0156961946055427 no 111 0.0377316481837097 58 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2909 7941780 10.49 µM 1.76010764640883 0.0165389496406762 no 112 0.0391947782810807 77 1243215
SGTC_1164 k060-0068 93.7 µM 1.75520247546176 0.0167815824692083 no 113 0.0396123403193037 70 5963676
SGTC_746 1095-0025 46.6 µM 1.75401264488792 0.0168408938406149 no 114 0.0397141702367358 65 6749286
SGTC_1286 0929-0070 131 µM 1.74736382200537 0.0171756384403912 no 115 0.0402871244077394 65 1420408
SGTC_745 0469-0705 296 µM 1.74312448572361 0.0173920289533192 no 116 0.0406559361827825 108 3486736
SGTC_3215 9129942 49.47 µM 1.73792748052313 0.0176604748735566 no 117 0.0411117963981915 77 17682944
SGTC_2143 5623677 140.463 µM 1.73446855891262 0.0178410951408233 no 118 0.0414174898582536 61 5375313
SGTC_307 1501-1223 22.3 µM 1.73439016784844 0.01784520681037 no 119 0.041424439212928 75 2830329
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.71870722526526 0.0186842087756654 no 120 0.042833847876485 77 676296 Flavone; oxidizing agent.
SGTC_224 benfluorex 43.875 µM 1.70656466290962 0.0193566578676905 no 121 0.0439514989583552 52 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1359 1582-0056 520 nM 1.70571638257802 0.0194043941359458 no 122 0.0440304489743501 72 3661189
SGTC_2217 6934799 96.0675 µM 1.70532782563592 0.0194262932311435 no 123 0.044066650395747 56 675606
SGTC_2671 danthron 100 µM 1.70323155603193 0.0195448016513511 no 124 0.0442623717230914 97 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_738 1315-0003 72.4 µM 1.68344774081143 0.0206937911904378 no 125 0.0461442239668239 69 6251474
SGTC_526 4469-0568 170 µM 1.68271007270737 0.0207377164752895 no 126 0.0462156154233079 78 2901964
SGTC_2998 9066762 71.4286 µM 1.68258681854293 0.02074506347718 no 127 0.0462275525946411 75 4945196
SGTC_1948 st076329 66.6 µM 1.67928725609964 0.0209425664626771 no 128 0.0465480367311031 55 24208413
SGTC_2551 apiole 73.87 µM 1.6755764074116 0.0211665870465088 no 129 0.0469105966008972 60 10659 A possible DNA adduct former.
SGTC_720 r052-1644 49.9 µM 1.67520708062337 0.0211889934773204 no 130 0.046946804401656 85 1422863 YOR257W CDC31
SGTC_2101 5377231 179.231 µM 1.6732008529761 0.021311058711043 no 131 0.0471438812514626 77 2844213
SGTC_1209 2323-2347 50.3 µM 1.67275176590872 0.0213384638902605 no 132 0.0471880869363801 69 5412760
SGTC_2292 7671323 168.05 µM 1.67267067179274 0.0213434157688934 no 133 0.0471960729400036 118 937504
SGTC_365 0121-0052 13.6 µM 1.66679364760311 0.0217048825419042 no 134 0.0477777219091697 74 3101739
SGTC_316 k060-0003 58.6 µM 1.66346763037468 0.0219117315930134 no 135 0.0481094325751996 74 6152314
SGTC_601 0986-0029 62.9 µM 1.65414927627182 0.0225001350181708 no 136 0.0490485930417048 79 24747981
SGTC_328 k915-0120 63.5 µM 1.6510911392997 0.0226961205636108 no 137 0.0493599831652758 53 6624543
SGTC_1640 st009078 66.4 µM 1.64796659939271 0.0228978457123819 no 138 0.0496797626803781 84 690618
SGTC_1104 tacrolimus 29.8 µM 1.64503945397462 0.023088195033843 no 139 0.04998083753981 97 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1553 gossypol 38.6 µM 1.63848081166192 0.0235195385915567 no 140 0.0506607168072916 52 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_29 0299-0004 12.984 µM 1.6191025064972 0.0248337829623438 no 141 0.0527126048070069 56 16871 A napthoquinone isolated from Swertia calycina.
SGTC_3160 9100216 49.47 µM 1.61753914380844 0.0249424445149431 no 142 0.0528809766416597 65 17191039
SGTC_767 0929-0023 86 µM 1.61469096823153 0.0251414317863536 no 143 0.0531888172040225 97 1204563
SGTC_357 1325-0123 420 µM 1.61288501785375 0.0252682921573993 no 144 0.0533847453713553 73 1098503
SGTC_2121 5257820 149.641 µM 1.61054549871157 0.0254334305079009 no 145 0.0536394105065112 63 791256
SGTC_651 3253-0966 34.4 µM 1.60831704844674 0.0255915685345984 no 146 0.0538828793442781 85 781462
SGTC_703 3875-0075 71.8 µM 1.60646101140047 0.0257239065202481 no 147 0.0540863274209382 93 2850814
SGTC_381 3461-2219 42.7 µM 1.6016870580225 0.0260669295374917 no 148 0.0546124142362242 83 2883159
SGTC_500 h-89 112 µM 1.59313786875413 0.0266907742929146 no 149 0.0555646328438233 97 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_3207 9114163 49.47 µM 1.59295151959397 0.0267045100895013 no 150 0.0555855336533039 114 849233
SGTC_2665 lovastatin 100 µM 1.59126002693798 0.0268294602257766 no 151 0.0557755343805244 79 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_183 3914-0051 30.55 µM 1.59013152354353 0.0269130936697345 no 152 0.0559025808127224 51 1596232
SGTC_1834 st055981 52.8 µM 1.58893215701513 0.0270022172360536 no 153 0.0560378551204576 92 471719 YDL150W RPC53
SGTC_938 3126-1755 342 µM 1.58755281875724 0.0271050187117261 no 154 0.0561937471465545 66 1777771
SGTC_2256 7954252 200 µM 1.5825726620525 0.027478909650124 no 155 0.056759449306533 92 2972920
SGTC_211 3455-0679 143.504 µM 1.5820180347362 0.0275208137817075 no 156 0.0568227267288031 66 748649
SGTC_790 1575-0012 79.1 µM 1.58164918098944 0.0275487115233758 no 157 0.056864839999482 88 378741 YLR208W SEC13
SGTC_1288 0973-0013 65.5 µM 1.57997669692741 0.0276755034975096 no 158 0.0570561016005493 80 4315430
SGTC_532 1548-0774 215 µM 1.5770599169889 0.0278977898441738 no 159 0.0573908695149408 98 5932993
SGTC_931 2812-0076 566 µM 1.57486595343144 0.0280659690735103 no 160 0.0576436944286267 98 3450959
SGTC_2106 5357045 167.29 µM 1.57398715317687 0.0281335702853416 no 161 0.0577452097420932 93 668842
SGTC_2116 5511452 16.8835 µM 1.56713776654469 0.0286651148281432 no 162 0.0585412466074982 92 870744
SGTC_942 3253-1115 227 µM 1.56596748177351 0.0287567645868454 no 163 0.0586781150758995 102 46497897
SGTC_2296 7971656 126.45 µM 1.56278147937602 0.029007508603729 no 164 0.059052000936078 69 666570
SGTC_2581 avocatin a 64 µM 1.55914844077125 0.0292956496041396 no 165 0.0594806253793388 84 6710728 A skin care supplement.
SGTC_281 1672-3440 14.9 µM 1.55899623111716 0.0293077732446643 no 166 0.0594986360981016 83 6833000
SGTC_1619 st003326 88.7 µM 1.5563840160366 0.0295164887906108 no 167 0.0598084018714535 70 2849032
SGTC_800 3448-7362 155 µM 1.55217706269911 0.0298552164023022 no 168 0.0603099314095742 155 15991913
SGTC_592 k241-0073 46.5 µM 1.55079210562485 0.0299674308277289 no 169 0.0604757565391201 92 4230158
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.54569482235478 0.0303834486316736 no 170 0.0610891441487533 109 6728940
SGTC_2002 4023503 131 µM 1.54559019008076 0.0303920381268048 no 171 0.0611017859406161 110 4736863 YCR052W RSC6
SGTC_356 1634-0012 32.5 µM 1.54380673696354 0.0305387554236464 no 172 0.0613175793897976 110 735457
SGTC_2226 7298446 200 µM 1.54377405867842 0.0305414491943674 no 173 0.0613215389298261 76 3283010
SGTC_2831 7999036 19.48 µM 1.5426362504674 0.0306353649946516 no 174 0.0614595286975716 89 2988270
SGTC_1078 idebenone 36.1 µM 1.54149480080148 0.030729821547733 no 175 0.0615982036702938 117 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_429 1112-0049 25.5 µM 1.53253834268111 0.0314793804359063 no 176 0.0626948216716002 89 2836170
SGTC_1569 carminic acid 40.6 µM 1.53179434841367 0.0315423188443483 no 177 0.0627865955742557 78 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2372 9071633 200 µM 1.52813960287481 0.0318530052972231 no 178 0.0632389402695832 87 21321366
SGTC_1046 2001-0062 216 µM 1.52614977462481 0.0320232187609091 no 179 0.0634862842111076 110 739778
SGTC_2585 alliin 100 µM 1.52348659428778 0.032252206592961 no 180 0.063818506042814 90 87310 A garlic compound which reacts with lipids.
SGTC_162 k030-0015 37.8 µM 1.5141612564659 0.0330647004122236 no 181 0.0649924727190622 95 1809920 YMR134W ERG29
SGTC_1082 camptothecin 424.86 nM 1.5129008662158 0.0331757978388171 no 182 0.0651524209313609 114 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_215 1287-0124 461.5 µM 1.50960408495301 0.0334678482477348 no 183 0.065572239199318 66 5560863
SGTC_3128 9127691 49.47 µM 1.50859583479077 0.0335575871245749 no 184 0.0657010496270591 79 41316314
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.50546117092678 0.0338378524416207 no 185 0.0661027762279306 86 61125 An anti-inflammatory.
SGTC_336 4111-0029 111 µM 1.50524228054576 0.0338574947960615 no 186 0.0661308993087723 88 3131175
SGTC_884 0851-0618 334 µM 1.50483904948495 0.0338937037060919 no 187 0.0661827307802996 99 9642473
SGTC_1417 3966-0327 90.4 µM 1.49705143581524 0.0345992777705134 no 188 0.0671899374264469 95 651118
SGTC_1084 voriconazole 435 nM 1.49311147564957 0.0349608164428149 no 189 0.0677040045657499 106 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_783 0848-0141 92.7 µM 1.49240964335661 0.0350255422197834 no 190 0.0677958942638972 122 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1658 st012944 20 µM 1.49171432404177 0.0350897642898581 no 191 0.0678870261901549 104 24207260
SGTC_598 3937-0236 20.2 µM 1.48778447575113 0.0354545572290224 no 192 0.0684038705143473 94 1379313
SGTC_3131 9127911 49.47 µM 1.48056955725068 0.0361323841465047 no 193 0.0693606563150748 95 45595681
SGTC_628 1636-0253 16 µM 1.47929519937729 0.0362532031088836 no 194 0.0695307176774645 114 4456143
SGTC_999 SEC7.066 22.7 µM 1.47834976822051 0.0363430508145367 no 195 0.0696570915323059 111 740511 YDR170C SEC7
SGTC_2046 4110841 106 µM 1.47608413617914 0.0365591037991719 no 196 0.0699606535112565 116 44119630 YMR134W ERG29
SGTC_2413 inermin 26.06 µM 1.47359416401843 0.0367977609750196 no 197 0.0702954468090919 137 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2305 7443522 69.23 µM 1.46933693087584 0.0372087557422724 no 198 0.0708707122952323 118 5415886
SGTC_2879 9041815 71.43 µM 1.46776683098341 0.0373612773208905 no 199 0.0710837850745279 59 4942971
SGTC_252 miconazole 1.30953 nM 1.4657104790828 0.0375618060868358 no 200 0.0713635890578294 126 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1292 0kpi-0043 232 µM 1.46520631810587 0.0376111041413902 no 201 0.0714323181746922 91 3333905
SGTC_1689 st020265 53.493 µM 1.46427047498761 0.0377027531295119 no 202 0.0715600304745998 100 5758320 YPR016C TIF6
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.45172273268982 0.0389492781652013 no 203 0.0732893578910919 66 4000243
SGTC_617 3770-0098 35 µM 1.44174080384403 0.0399647011856043 no 204 0.074687753999086 102 5962639
SGTC_2179 6298986 200 µM 1.44082083130485 0.0400593593696276 no 205 0.0748176533761433 97 738374
SGTC_669 0108-0021 26.2 µM 1.43993102740067 0.0401510866604716 no 206 0.0749434568803671 97 17201
SGTC_82 0054-0107 293.755 µM 1.43641081966372 0.040515648773421 no 207 0.0754427380976936 89 3104697
SGTC_2636 apigenin dimethyl ether 100 µM 1.43534762049123 0.0406262833871604 no 208 0.0755940320545535 106 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3182 9108849 49.47 µM 1.43227158657302 0.0409477515310783 no 209 0.0760330556899291 97 17133045
SGTC_3269 9137823 49.47 µM 1.42956141593718 0.041232691223468 no 210 0.076421468084487 72 17682936
SGTC_2297 7971671 152.32 µM 1.42809855464954 0.0413871590492123 no 211 0.0766317467393634 113 909016
SGTC_2447 5741742 33.78 µM 1.42266488468288 0.0419650271258809 no 212 0.0774166623941566 119 1776504
SGTC_2349 9023730 187.07 µM 1.41802235886951 0.0424639163734092 no 213 0.0780921185384207 91 4126287
SGTC_1330 1469-0054 61.8 µM 1.4161081699864 0.0426710082634634 no 214 0.0783719182107191 111 7102664
SGTC_653 0203-0016 55.2 µM 1.41047108134083 0.0432856189179313 no 215 0.0792003148047272 113 295302
SGTC_714 4296-0578 26.1 µM 1.40713563638022 0.0436526352830496 no 216 0.0796935863588987 98 1589775
SGTC_1799 st045822 46.1415 µM 1.40682667111178 0.0436867590380771 no 217 0.0797393958985113 121 3674992
SGTC_1996 st072960 66.8 µM 1.40612077721479 0.0437648024516028 no 218 0.0798441318313811 108 1719405
SGTC_762 1165-0429 115 µM 1.40558209821584 0.0438244342740173 no 219 0.0799241274759564 120 5967793
SGTC_993 3909-8757 62.7 µM 1.39814495745165 0.0446544446481909 no 220 0.0810347708737119 88 4288324 YLR208W SEC13
SGTC_2880 9042983 58.44 µM 1.39764385875583 0.0447108211967738 no 221 0.0811100204421077 133 6464714
SGTC_83 0170-0301 39.027 µM 1.39571244607791 0.044928652922028 no 222 0.081400552421868 80 3089716
SGTC_1119 parthenolide 318.541 nM 1.39507507266647 0.0450007254067649 no 223 0.0814966011164417 126 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_477 mead ethanolamide 10 µM 1.39403073651519 0.0451190172775076 no 224 0.0816541615844543 53 16061185
SGTC_616 4092-0450 108 µM 1.38782355106547 0.0458272771974213 no 225 0.0825953907567098 105 787165
SGTC_1743 st037606 46.3785 µM 1.38364836618941 0.0463086856150512 no 226 0.0832330754689137 97 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_967 1306-0166 352 µM 1.37825329303426 0.0469367539757764 no 227 0.0840625491722639 127 4437607
SGTC_989 1501-0895 10.3 µM 1.37564002524968 0.0472434243941957 no 228 0.0844665542362966 98 2830112
SGTC_2563 tomatine 8.54 µM 1.37530878047948 0.0472824108285673 no 229 0.0845178677500515 115 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.37380362046203 0.0474598881642611 no 230 0.0847513284307794 127 688798
SGTC_847 0342-0274 5.54 µM 1.36210514637884 0.0488575458370941 no 231 0.0865823522063206 133 18097
SGTC_3155 9099265 49.47 µM 1.36147525291936 0.0489337248210184 no 232 0.0866817744531864 107 25236499
SGTC_3144 9087057 49.47 µM 1.35700436624129 0.0494771624297385 no 233 0.0873899115911486 106 17249618
SGTC_2976 9009005 19.48 µM 1.35485320212621 0.0497403480988933 no 234 0.0877321660930953 87 2993148
SGTC_1917 st066507 28.5 µM 1.35322437737263 0.0499403698632499 no 235 0.0879919798515034 133 3156428
SGTC_1249 0481-0015 10.2 µM 1.35183661657216 0.0501112943003611 no 236 0.088213793798299 132 4227577
SGTC_538 2922-0838 53.3 µM 1.34979918679992 0.0503630802821644 no 237 0.0885402028924181 139 777039
SGTC_273 hydroxyurea 18.1 mM 1.34451927410588 0.0510202658995057 no 238 0.0893902640173007 140 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_200 k038-0079 37.545 µM 1.34199240230479 0.0513371890349319 no 239 0.0897992295710314 135 3436683
SGTC_446 go6976 132 µM 1.34124596766489 0.0514311067386594 no 240 0.0899203031588283 111 3501 A protein kinase C inhibitor.
SGTC_2401 5128683 200 µM 1.34092032113114 0.0514721229406131 no 241 0.0899731618427308 115 708373
SGTC_2355 9061122 103.12 µM 1.3352846867034 0.0521860775239074 no 242 0.0908915942986413 126 5302957
SGTC_2492 derrusnin 100 µM 1.32776442721927 0.0531510121312781 no 243 0.0921279710264367 132 1715307 Part of coumarin class of compounds.
SGTC_2404 5161160 200 µM 1.32511172743083 0.0534947391831087 no 244 0.0925670485072718 154 2831543
SGTC_76 0433-0009 400.328 µM 1.32325709847469 0.0537360995846975 no 245 0.0928749467434681 123 2841569
SGTC_571 k831-0106 44.2 µM 1.32155966373745 0.0539577579713238 no 246 0.0931574112792845 127 4783639
SGTC_1702 st027038 51 µM 1.31616323459299 0.0546672585352701 no 247 0.0940596303359557 109 5521182
SGTC_2384 9036245 200 µM 1.31501457520433 0.0548192275645864 no 248 0.0942525020388423 92 6462766
SGTC_61 0978-8327 98.565 µM 1.31457366226854 0.054877649493402 no 249 0.0943266132721054 117 6150059 YHR072W ERG7
SGTC_1736 st036774 51 µM 1.31155924796328 0.0552783852477467 no 250 0.0948344453376056 131 1272247
SGTC_2438 5259590 200 µM 1.30827489221168 0.0557176340680773 no 251 0.0953900440074287 126 1201127
SGTC_3233 9132340 49.47 µM 1.3072517982984 0.0558550235763786 no 252 0.095563604392181 151 17682950
SGTC_739 1486-1183 203 µM 1.30595524796074 0.0560295189019478 no 253 0.0957838883789864 110 4346692
SGTC_1825 st052143 62.6 µM 1.30451328099386 0.0562240897093091 no 254 0.0960293171323789 115 674173
SGTC_1703 st026983 48.3 µM 1.29721191476521 0.0572174846057204 no 255 0.097279141131133 107 1104023
SGTC_40 0327-0103 19.753 µM 1.29381863313703 0.0576838382719478 no 256 0.0978640374762937 114 409036
SGTC_3297 9117502 71.43 µM 1.29182485536361 0.0579592428673751 no 257 0.0982089028237005 89 7453720
SGTC_2704 st078022 71.1 µM 1.29167552095828 0.057979912265118 no 258 0.0982347691069448 126 54697681
SGTC_1043 0916-0009 19.3 µM 1.28965985499316 0.0582594680774406 no 259 0.0985843919431773 140 3101130
SGTC_2705 st078069 42.8 µM 1.28828832147622 0.0584502927613876 no 260 0.0988228084485666 120 1530061
SGTC_798 1287-0182 476 µM 1.28804605744584 0.0584840504749009 no 261 0.0988649655133288 124 1649755
SGTC_1200 1643-0193 18.4 µM 1.28625378199696 0.0587342666889939 no 262 0.099177253372754 139 5403974
SGTC_1620 st003704 16.5 µM 1.28595626155231 0.0587758841575223 no 263 0.0992291633675624 135 2834414
SGTC_2227 7312221 64.1025 µM 1.284949852089 0.0589168333291646 no 264 0.0994049043117539 134 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1688 st021091 57.6 µM 1.28405662138651 0.0590421536691103 no 265 0.0995610722723864 123 3656366
SGTC_2437 5741531 144.16 µM 1.28292425889223 0.0592013246806979 no 266 0.0997593064562427 149 2262990
SGTC_2419 paclitaxel 166.5 µM 1.28265879918823 0.0592386877842122 no 267 0.0998058201831028 135 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2533 agelasine 13.65 µM 1.28133535301952 0.0594252370535987 no 268 0.100037950194718 131 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2932 9016711 44.54 µM 1.2812140304113 0.0594423613667222 no 269 0.100059249665589 126 7117328
SGTC_2549 cedrol 20.94 µM 1.27999289236309 0.0596149367296405 no 270 0.100273817819814 144 6708665 A sedative which affects the nervous system.
SGTC_909 3448-9333 149 µM 1.27693693483929 0.060048535819882 no 271 0.100812256542183 125 3344074
SGTC_3021 9087658 49.47 µM 1.27375493167816 0.0605026394441145 no 272 0.101375140959208 100 25237042
SGTC_2777 climbazole 1.536 µM 1.27278769668486 0.0606412047259804 no 273 0.101546694095273 140 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_608 k048-0125 159 µM 1.27217926522196 0.060728495219307 no 274 0.101654716498718 129 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1691 st019933 84.6 µM 1.27139713374819 0.0608408504416789 no 275 0.101793700902217 137 6176082
SGTC_1814 st052110 31.539 µM 1.26865983732622 0.0612353504628463 no 276 0.102281206360126 129 674163
SGTC_1751 st044839 27.194 µM 1.26668891101814 0.0615206366049613 no 277 0.102633273298706 117 5291326
SGTC_1246 0422-0085 105 µM 1.26482512858293 0.0617913678682621 no 278 0.102967010682117 144 264295
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.26448127843657 0.0618414166783844 no 279 0.103028668100227 130 756377
SGTC_1972 st070201 17.4 µM 1.26325705768733 0.0620198639745463 no 280 0.103248406701661 129 2829099
SGTC_468 gf-109203x 121 µM 1.26294626882066 0.0620652296857115 no 281 0.103304245132646 81 2396 A protein kinase C inhibitor.
SGTC_1431 4049-0260 9.09 µM 1.25916858093442 0.062618729321705 no 282 0.103984723705691 147 3854841
SGTC_1763 st044482 94.5 µM 1.25764049530361 0.0628437114651395 no 283 0.104260900589019 144 88505
SGTC_478 N-arachidonylglycine 10 µM 1.25155955790977 0.0637452612900955 no 284 0.105365199427816 76 5283389
SGTC_715 0868-0130 184 µM 1.25138414263231 0.0637714165977825 no 285 0.105397179940808 104 2876258
SGTC_1643 st009866 20.2 µM 1.24713263710609 0.0644078940721054 no 286 0.106174433841388 123 3156273 YOR207C RET1
SGTC_1813 st051246 8.6015 µM 1.24154564220826 0.0652517946676197 no 287 0.107202124072512 126 5291959
SGTC_168 3970-0862 530.542 µM 1.24032095396408 0.0654379218420128 no 288 0.107428352532014 191 3135186
SGTC_1508 1080-0625 72.9 µM 1.23951537200852 0.0655605779046568 no 289 0.107577349789297 130 767111
SGTC_2076 5212012 200 µM 1.23904618146411 0.0656320978904733 no 290 0.107664198010733 121 604802
SGTC_1184 1269-1718 139 µM 1.23816769743508 0.0657661702360768 no 291 0.107826943186131 132 5403821
SGTC_1470 k295-0292 231 µM 1.23520208268015 0.0662203444050962 no 292 0.108377652180819 150 5045612
SGTC_516 3992-2719 87.3 µM 1.23344166594709 0.0664910932297148 no 293 0.108705513964988 98 5350887 YDR037W KRS1
SGTC_1946 st076057 65.1 µM 1.2327893270584 0.0665916390765896 no 294 0.108827187164367 116 953009
SGTC_2641 levomentholum 100 µM 1.23192741742579 0.0667246667544743 no 295 0.108988099277479 123 16666
SGTC_2300 7976697 71.57 µM 1.23151865348779 0.0667878274855928 no 296 0.109064472219627 113 2236109
SGTC_2736 butenafine 14.65 µM 1.23129335436476 0.0668226596644005 no 297 0.10910658326428 132 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.22738813260885 0.0674286588626129 no 298 0.109838372328085 129 75037 A free radical scavenger.
SGTC_3324 9138759 60.749 µM 1.22709191076728 0.0674747983228358 no 299 0.109894023941619 116 45595710
SGTC_1311 1190-0148 100 µM 1.22631260925708 0.0675962987147535 no 300 0.110040529047599 151 1961333
SGTC_1633 st005664 67.9 µM 1.22535007016157 0.0677466008143947 no 301 0.110221675336997 124 2063822
SGTC_2135 5326629 150.42 µM 1.22534059567477 0.0677480815534328 no 302 0.11022345946264 125 5020077
SGTC_323 4013-0906 34.3 µM 1.2245439542115 0.0678726756980275 no 303 0.110373547856248 128 2910086
SGTC_2163 5671233 125 µM 1.22083355845887 0.0684553115806269 no 304 0.111074522472118 146 701023
SGTC_2789 5281112 71.43 µM 1.21674461920892 0.0691018503288231 no 305 0.111850698431886 130 765948
SGTC_128 0906-2981 13.371 µM 1.2115784838987 0.0699254303541117 no 306 0.112836887435277 156 6740226
SGTC_2245 6637752 200 µM 1.21035065362885 0.0701222762813422 no 307 0.11307218425625 123 681890
SGTC_2271 7849410 118.62 µM 1.20946186499546 0.0702650327590062 no 308 0.113242726725707 145 972430
SGTC_1572 epiandrosterone 68.9 µM 1.20942343390099 0.0702712105662055 no 309 0.113250105094544 128 441302 A steroid.
SGTC_2498 4'-Methoxychalcone 54.63 µM 1.20545619420736 0.0709111951973024 no 310 0.114013619624642 125 641818 YHR062C RPP1
SGTC_1208 2323-2347 50.3 µM 1.20524910194793 0.0709447253300028 no 311 0.114053576004525 122 5412760
SGTC_1158 4092-0494 91.8 µM 1.20279009125587 0.071343793051276 no 312 0.114528780095007 125 1148199
SGTC_1349 flufenamic acid 69 µM 1.20276204503933 0.0713483545311017 no 313 0.114534208145649 148 3371 A non-steroidal anti-inflammatory.
SGTC_1159 4092-0538 61.2 µM 1.20259189247781 0.0713760332046436 no 314 0.114567143312136 150 717301
SGTC_2123 5259487 200 µM 1.20205989736713 0.0714626258807933 no 315 0.114670161133075 134 2173474
SGTC_1941 st076221 61.8 µM 1.19863669116765 0.0720217496964505 no 316 0.115334622371417 147 2828568
SGTC_1808 st050063 61.5 µM 1.19682667154759 0.0723187386896076 no 317 0.115687060082278 139 4011993
SGTC_2184 6075246 200 µM 1.19140382735682 0.0732141402446322 no 318 0.116747545569873 133 2267320
SGTC_3354 9151612 71.43 µM 1.18512635284088 0.0742612198531898 no 319 0.117983746528259 126 27261949
SGTC_1011 4112-3381 17.4 µM 1.18485102923404 0.0743074041319005 no 320 0.118038176204657 149 2877139
SGTC_3042 9091578 49.47 µM 1.18270233314715 0.0746685919377658 no 321 0.118463569607476 127 25236497
SGTC_1867 st057372 64 µM 1.18185399586245 0.0748115626182102 no 322 0.118631819267472 123 688837
SGTC_2514 salinomycin 42.74 µM 1.18119745365842 0.0749223532784509 no 323 0.118762146300845 147 23682228 A polyether potassium ionophore.
SGTC_363 0455-0021 3.06 µM 1.1803104276906 0.0750722364977028 no 324 0.118938386142388 161 4597466
SGTC_285 1486-1325 46 µM 1.17998795481009 0.0751267822665793 no 325 0.119002502816264 160 22310230
SGTC_2093 5331342 194.4 µM 1.17743761937267 0.0755592325289242 no 326 0.119510441037618 153 33839
SGTC_1968 st069590 43.6 µM 1.17317137363708 0.0762868795410299 no 327 0.120363544580529 164 6384066
SGTC_3343 9148379 18.9835 µM 1.17039681358021 0.0767629599335838 no 328 0.120920658688688 132 1955036
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.16755057031331 0.0772536842166341 no 329 0.121494049252091 158 7104
SGTC_1930 st074634 34.3 µM 1.1665000092034 0.0774354136950855 no 330 0.121706172435721 148 684253 YOR116C RPO31
SGTC_2309 7664088 163.95 µM 1.16338084290496 0.0779768902940231 no 331 0.122337509280163 154 704922
SGTC_782 0083-0095 30.5 µM 1.16054948529868 0.0784708874211418 no 332 0.122912579214082 146 3591729 An indicator and reagent.
SGTC_1793 st048256 72.231 µM 1.16042988722907 0.0784918062313423 no 333 0.122936912130334 140 672022
SGTC_1779 st039427 55 µM 1.15997908622334 0.0785706935025246 no 334 0.123028660549535 150 1124498
SGTC_2111 5486399 200 µM 1.15745061901012 0.0790142731653722 no 335 0.123544151658946 150 689674
SGTC_734 2023-0417 80 µM 1.15500263803128 0.0794455373938059 no 336 0.124044673089523 165 3935732
SGTC_961 1252-1571 372 µM 1.15322805408805 0.0797592804311243 no 337 0.12440839575551 153 6813498
SGTC_426 0988-0037 14.6 µM 1.14856367539757 0.0805884020402209 no 338 0.125367971289283 172 5383008
SGTC_1711 st032263 62.8 µM 1.14567169773959 0.081105728214796 no 339 0.125965509325816 150 3958979
SGTC_368 fentichlor 4.58 µM 1.14448159597044 0.0813193437830863 no 340 0.126211983033269 155 7329 A pesticide.
SGTC_2491 paeonol 100 µM 1.14395994237248 0.0814131109074034 no 341 0.126320124975935 138 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2462 5162487 171.77 µM 1.14342485139486 0.0815093781008411 no 342 0.126431119637394 148 2259986
SGTC_3257 9139206 32.98 µM 1.14244947452389 0.081685077098712 no 343 0.126633618188268 150 4910041
SGTC_2453 5731132 22.18 µM 1.14219147214032 0.0817315999381828 no 344 0.126687219967345 173 1362040
SGTC_26 0302-0163 425.158 µM 1.13485445409286 0.0830629819008184 no 345 0.128218152980381 185 3100915
SGTC_2180 6301957 200 µM 1.13223032858347 0.0835430973882495 no 346 0.128768806258793 161 845462
SGTC_1656 st012921 11 µM 1.12764436808413 0.0843871564612076 no 347 0.129735070514854 151 6732821
SGTC_201 4262-0159 12.803 µM 1.126371263554 0.084622605906515 no 348 0.130004202493169 150 1341029
SGTC_892 0929-0076 29 µM 1.12628254468255 0.0846390320250689 no 349 0.130022971894255 146 5751038
SGTC_1401 3807-4679 7.6 µM 1.12347604220517 0.085159885418777 no 350 0.130617685026488 167 3291456
SGTC_1893 st059353 36.1 µM 1.12143178442403 0.0855407845818588 no 351 0.131052056534719 172 3112488
SGTC_3319 9138450 16.7555 µM 1.1213197882986 0.0855616892179425 no 352 0.131075882689463 142 2029690
SGTC_636 0kpi-0074 126 µM 1.11863993202389 0.0860630393783662 no 353 0.131646890302597 150 616434
SGTC_2516 gossypol 71.55 µM 1.11793488602487 0.0861953045484376 no 354 0.1317974020527 156 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1701 st028638 40.4 µM 1.11766623293584 0.0862457432982423 no 355 0.131854784779868 139 3490878
SGTC_462 ag-879 158 µM 1.1168917852185 0.0863912668951 no 356 0.132020298721951 177 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2379 9035213 200 µM 1.11660620887698 0.0864449747951341 no 357 0.132081367863827 164 646551
SGTC_1514 1189-1591 158 µM 1.1154813870575 0.0866567611171262 no 358 0.132322095106559 176 767698 YMR146C TIF34
SGTC_2449 5812982 45.77 µM 1.11235885259244 0.0872467177151858 no 359 0.132991944450655 135 776185
SGTC_2214 7179297 48.276 µM 1.10905157714868 0.0878748430743148 no 360 0.133703966256238 146 769744
SGTC_1924 st058459 75.1 µM 1.1071985837201 0.0882282388250994 no 361 0.134104039877119 142 688683
SGTC_1927 st060202 13.8 µM 1.10272285575826 0.0890862001534031 no 362 0.135073769065845 160 688887
SGTC_170 4197-0004 226 µM 1.10167815134708 0.0892873525369488 no 363 0.135300809418305 177 218692
SGTC_2216 7189485 200 µM 1.10042436140726 0.0895292091414673 no 364 0.135573634466642 153 731273
SGTC_2889 9059656 51.95 µM 1.10020281239798 0.0895719966422954 no 365 0.135621882752376 159 3949838
SGTC_1874 staurosporine 7.6 µM 1.10003020504888 0.08960534263473 no 366 0.135659480820043 166 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3235 9132602 49.47 µM 1.09775993550508 0.0900447952345704 no 367 0.136154665195467 179 4912240
SGTC_3190 9110366 49.47 µM 1.09427674378389 0.0907221415113771 no 368 0.136916810923706 142 17123768
SGTC_756 0508-1999 28.3 µM 1.09316512560285 0.0909391022915665 no 369 0.13716065300035 162 6753853
SGTC_398 bronopol 33.3 µM 1.09281820737317 0.091006891022104 no 370 0.137236812908092 189 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1432 4049-0298 68.4 µM 1.09132775162696 0.0912985564586875 no 371 0.137564345317583 153 741646
SGTC_1829 berberine 14.4 µM 1.08944002035792 0.0916689582399097 no 372 0.137979945619504 182 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1647 st011722 22.4 µM 1.08682664860258 0.0921835778236436 no 373 0.138556714117426 161 2854783
SGTC_1031 k035-0009 16 µM 1.08637309930267 0.0922731071433215 no 374 0.13865697902898 178 5180959
SGTC_1379 2144-0755 36.5 µM 1.08584853497589 0.0923767348651424 no 375 0.13877300466648 183 5392327
SGTC_2316 5844804 197.44 µM 1.08569695045307 0.0924066964320632 no 376 0.138806545164952 182 776813
SGTC_2770 toltrazuril 17.5 µM 1.08543444277964 0.0924585996160417 no 377 0.138864642241221 153 68591 Kills coccidiodes.
SGTC_181 1447-1644 8.07 µM 1.08523840636666 0.0924973741268836 no 378 0.138908038980755 180 534600
SGTC_2667 digitoxin 100 µM 1.08106551469647 0.0933255962453124 no 379 0.139833986009128 124 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2272 7805186 180 µM 1.07896040187593 0.0937454855636142 no 380 0.140302690198714 181 2956062 YPR165W RHO1
SGTC_1181 1222-0449 220 µM 1.07819574989735 0.0938983491178023 no 381 0.140473204119161 163 658318
SGTC_846 0335-0850 148 µM 1.07795601599212 0.0939463128026117 no 382 0.140526692649382 160 6819598
SGTC_845 0330-0138 4.51 µM 1.07783315210976 0.0939709012488913 no 383 0.140554110936254 183 9039800
SGTC_2318 6029776 164 µM 1.07760142386661 0.0940172893764632 no 384 0.14060583326144 161 818325
SGTC_1032 k061-1018 98.7 µM 1.07672714760662 0.0941924570338574 no 385 0.140801090221563 153 4005393
SGTC_3218 9131285 49.47 µM 1.07568988280698 0.0944005927537698 no 386 0.141032986829537 175 17156417
SGTC_2744 captopril 92.04 µM 1.07540297556315 0.0944582228862035 no 387 0.14109717509275 103 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1902 st060212 70.5 µM 1.07488266520772 0.0945628021214865 no 388 0.141213631951974 158 688944
SGTC_819 1013-0258 27.7 µM 1.07295708879533 0.0949505738160671 no 389 0.141645184885493 177 5753198
SGTC_120 rhodamine 6G 52.259 µM 1.0702468752576 0.0954983382869062 no 390 0.142254099964856 205 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1909 st060837 51.5 µM 1.07002013416371 0.0955442704095281 no 391 0.142305123011169 170 678937
SGTC_65 0798-0905 34.986 µM 1.0699124778265 0.0955660846051162 no 392 0.142329353012981 162 3602145
SGTC_1023 4482-3888 16 µM 1.068364708244 0.0958801114060658 no 393 0.142678015026414 183 3303168
SGTC_3069 9117009 49.47 µM 1.06708871499198 0.096139567764102 no 394 0.142965888623979 153 41904981
SGTC_3032 9089427 49.47 µM 1.0670007921435 0.0961574647032154 no 395 0.142985739118543 148 17173707
SGTC_543 3844-1095 191 µM 1.06605010758317 0.0963511356152197 no 396 0.143200495766966 200 4230703
SGTC_291 SEC14.278 35.5 µM 1.06219284351252 0.0971398684790482 no 397 0.144074074021285 165 1068044
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.06198702956914 0.0971820860577396 no 398 0.144120786742177 178 66535 A nucleotide analog.
SGTC_3018 9082602 49.47 µM 1.0575719642811 0.0980909711044224 no 399 0.145125314860741 180 17332089
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.05710481221015 0.0981875021412053 no 400 0.145231877617039 158 5379071
SGTC_2310 7668677 200 µM 1.05546160546705 0.0985276028120992 no 401 0.14560713018506 195 2197143
SGTC_25 0118-0223 35.662 µM 1.05029521896141 0.0996025267207925 no 402 0.146791201327457 175 5333628
SGTC_37 0566-0070 1.56 µM 1.05012220074377 0.0996386727949541 no 403 0.146830966409555 164 1626686
SGTC_221 trifluoperazine 10.304 µM 1.04969567662434 0.0997278209526223 no 404 0.146929026062319 216 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_3175 9106517 49.47 µM 1.04618258603589 0.100464312370729 no 405 0.147738370629967 174 41468073
SGTC_1315 1237-0019 3.69 µM 1.04445245017094 0.100828476614146 no 406 0.148138053872845 160 825140
SGTC_153 4077-0274 519.67 µM 1.0441060547251 0.100901502480877 no 407 0.148218162449138 186 3121976
SGTC_887 0885-0007 9.62 µM 1.04111651616242 0.101533349467324 no 408 0.148910737549636 182 5719458
SGTC_1452 4194-0072 190 µM 1.03963090485794 0.10184840702911 no 409 0.149255706483081 173 1343545
SGTC_866 0495-0101 262 µM 1.03822714402633 0.102146759641684 no 410 0.149582159140062 164 635694
SGTC_1809 st050081 57.6 µM 1.03602548269512 0.102615976297802 no 411 0.15009512715391 190 5036894
SGTC_3310 9130229 44.1445 µM 1.03027830389196 0.103848189914107 no 412 0.151439690396642 161 7761258
SGTC_1706 st031321 9.9705 µM 1.02818750010494 0.104299116815349 no 413 0.151930818576469 176 6103185
SGTC_2015 5119600 184 µM 1.02788547778452 0.104364371560166 no 414 0.152001850746897 198 2828786
SGTC_802 4112-3352 742 µM 1.02535102122727 0.104913130708628 no 415 0.152598794852365 167 704594
SGTC_2014 4013930 200 µM 1.02481800070478 0.105028805403663 no 416 0.152724535604832 197 64556
SGTC_254 nsc-64875 3.808 µM 1.02294489487412 0.105436034025584 no 417 0.153166950477786 151 56993
SGTC_1079 idarubicin 2.36 µM 1.01620736162132 0.106910269503132 no 418 0.154765325772653 210 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1263 0774-1208 64.8 µM 1.01278420638132 0.10766495981987 no 419 0.155581623069275 208 906585
SGTC_2220 6782180 200 µM 1.01181561095281 0.107879197474224 no 420 0.155813112201061 152 833803
SGTC_2877 9040724 71.43 µM 1.01151285847642 0.10794622436789 no 421 0.155885514986173 159 6463895
SGTC_2439 5492030 7.2 µM 1.00277190463876 0.109894347452524 no 422 0.157985463742155 188 5722370
SGTC_2050 5263056 171 µM 1.00262815365736 0.109926595193506 no 423 0.15802015335496 183 763468 YGL055W OLE1
SGTC_2223 6903751 107.57 µM 1.00160859423815 0.110155508440362 no 424 0.158266334276809 181 5598863
SGTC_1392 3455-1037 33.9 µM 1.00126734521756 0.110232202585308 no 425 0.158348787813218 166 981132
SGTC_2497 7-hydroxyflavone 100 µM 1.00103248484028 0.110285008617206 no 426 0.158405551799992 209 5281894
SGTC_1008 4106-0037 6 µM 0.998690382127166 0.110812599951176 no 427 0.158972350618801 207 2905394
SGTC_1332 1480-0653 17.5 µM 0.996293258950461 0.111354455475316 no 428 0.159553839075322 172 5749438
SGTC_1546 5-methoxyflavanone 78.7 µM 0.994869556727602 0.111677171266707 no 429 0.159899855503141 162 147795
SGTC_2601 securinine 100 µM 0.992352168732213 0.112249433210895 no 430 0.16051288148718 228 442872 A GABA receptor antagonist.
SGTC_1219 1469-0211 33.1 µM 0.99090023047647 0.112580444562661 no 431 0.160867149907871 204 6822282
SGTC_493 zm226600 134 µM 0.989519584736552 0.112895848845198 no 432 0.161204496286033 192 5240098 A potassium channel opener. YCR052W RSC6
SGTC_253 dyclonine 31.25 µM 0.986396833122325 0.113611557418252 no 433 0.161969209259656 171 3180 An oral anasthetic.
SGTC_953 1188-0045 9.7 µM 0.981343963573052 0.114776474142676 no 434 0.163211574807158 193 6144426
SGTC_3318 9139014 38.6185 µM 0.97786154282263 0.115584261785698 no 435 0.164071403881072 210 16643984
SGTC_1428 4049-0204 61.7 µM 0.976826536237861 0.115825120230794 no 436 0.164327518185569 206 X1428
SGTC_513 4245-1575 41.7 µM 0.976552642696566 0.115888918140028 no 437 0.164395337002007 208 719745
SGTC_649 1123-0311 367 µM 0.976320877665067 0.115942922559684 no 438 0.164452738543403 198 693629 YIL048W NEO1
SGTC_111 0083-0039 52.457 µM 0.974786817622128 0.116300830072744 no 439 0.164833008696684 155 759313
SGTC_3076 9116187 49.47 µM 0.973587519469465 0.116581180635947 no 440 0.16513069282015 179 27241210
SGTC_1995 st072814 61.1 µM 0.972499217676852 0.116835998931016 no 441 0.165401126944974 179 5769371
SGTC_378 3970-0959 8.33 µM 0.970613422100752 0.117278479139558 no 442 0.165870409797748 200 6615653
SGTC_327 1273-0057 3.96 µM 0.969160137808399 0.117620284424325 no 443 0.166232648206195 186 3108138
SGTC_450 aminopyrene 156 nM 0.96784564003306 0.11793005463981 no 444 0.166560733130743 201 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1120 ficusin 1.78878 µM 0.966548900142739 0.118236205181536 no 445 0.166884795112649 185 6199 A DNA cross-linker.
SGTC_2556 citropten 84.59 µM 0.966283183440532 0.118299008210898 no 446 0.166951249259953 172 2775 A potential DNA crosslinker.
SGTC_2791 5663188 71.43 µM 0.965982707696181 0.11837005506588 no 447 0.167026416993626 211 54690634
SGTC_2746 daunorubicin 9.88 µM 0.964034793518384 0.11883136687873 no 448 0.167514241117117 150 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_774 k060-0086 136 µM 0.963068541711915 0.119060668575597 no 449 0.167756563748406 191 5911235
SGTC_2772 vinpocetine 57.06 µM 0.958870010373059 0.120060651476855 no 450 0.168812117190183 194 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2034 5197015 53.07 µM 0.958008805959743 0.120266497847575 no 451 0.169029159064648 196 780676
SGTC_3116 9124943 49.47 µM 0.955567506091981 0.120851372030531 no 452 0.16964539232864 193 41905195 YPL160W CDC60
SGTC_2426 5582046 32.21 µM 0.95447449319667 0.121113878187701 no 453 0.169921757256214 181 2251934
SGTC_2809 7964133 12.99 µM 0.953889526918368 0.121254532725593 no 454 0.170069782675804 208 1253665
SGTC_1596 piperlongumine 63 µM 0.952796812131502 0.121517582501604 no 455 0.17034651490906 175 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_713 1488-1073 324 µM 0.951027476569066 0.121944365673799 no 456 0.170795213986052 202 3312542
SGTC_1058 3448-5425 97.3 µM 0.950839321418776 0.121989812618715 no 457 0.170842974116098 212 7279705
SGTC_2898 9056270 58.44 µM 0.950663125486245 0.122032381721735 no 458 0.170887706340738 143 19154699
SGTC_2068 5226020 147 µM 0.950459601446859 0.122081566304475 no 459 0.170939385890187 193 1810509
SGTC_1848 st056003 16.4 µM 0.950272670739818 0.122126753126803 no 460 0.170986860810013 194 146492
SGTC_502 l-744,832 89.3 µM 0.949457861046948 0.122323854502181 no 461 0.171193897087756 190 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_702 1488-0190 94 µM 0.946420034271855 0.123060668332569 no 462 0.171967195459251 163 949357
SGTC_1265 0819-1001 68.8 µM 0.944806429420582 0.123453304965436 no 463 0.172378854426146 210 3106768
SGTC_2887 9044784 58.44 µM 0.943832996621304 0.123690593192718 no 464 0.172627497988574 214 6465546
SGTC_2624 nerol 100 µM 0.943242900010983 0.123834593091375 no 465 0.172778337405226 211 637566 A natural product oil.
SGTC_2995 9067767 71.4286 µM 0.938740425953282 0.124937185357146 no 466 0.173932016157146 163 11673567
SGTC_2955 9076254 12.21 µM 0.936882650718562 0.125394121051704 no 467 0.174409462197565 182 16459619
SGTC_813 k007-0158 173 µM 0.933024568625444 0.126346772734996 no 468 0.175403641658468 200 6523916
SGTC_56 0957-0365 83.25 µM 0.9329464513285 0.126366113692881 no 469 0.175423808545226 188 6752360
SGTC_3328 9140624 29.0385 µM 0.926797782928785 0.127894929898026 no 470 0.177015768152045 199 4904392
SGTC_2919 7978188 46.38 µM 0.925358941256431 0.128254534090674 no 471 0.177389614381925 189 2980291
SGTC_924 2046-0044 21.3 µM 0.924097620918901 0.128570348072099 no 472 0.177717745933055 192 3623589
SGTC_1391 3442-0225 151 µM 0.922010355659162 0.129094149884968 no 473 0.178261587032329 194 5227075
SGTC_1387 3342-1166 1.8 µM 0.919622323652176 0.129695242033365 no 474 0.178885078414078 180 3418228
SGTC_2194 5927483 104.545 µM 0.917389755925397 0.130258952930971 no 475 0.179469219425031 183 760979
SGTC_1222 0366-0074 1.18 µM 0.916694208388387 0.130434920619928 no 476 0.17965145091896 215 286520
SGTC_2083 5306046 65.942 µM 0.91449064514971 0.130993488872304 no 477 0.180229545604558 205 539837
SGTC_893 0958-0369 48.9 µM 0.913781965330814 0.131173478661636 no 478 0.180415712340183 210 6819948
SGTC_2669 eugenol 100 µM 0.910468738718081 0.132017234387573 no 479 0.181287680458838 181 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2751 anetholtrithion 17.25 µM 0.907056885182505 0.132890010684217 no 480 0.182188358122447 196 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2674 ligustilide 100 µM 0.905779197163762 0.133217872504299 no 481 0.18252636698318 208 5319022 A signalling regulator.
SGTC_3337 9144342 33.5465 µM 0.905274858122596 0.133347441785667 no 482 0.182659896240345 201 17682949
SGTC_395 anisomycin 6.25 µM 0.905174530470946 0.133373227205988 no 483 0.182686466351402 214 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2461 5755302 26.15 µM 0.904669769906858 0.133503008816587 no 484 0.182820180406435 222 2788904
SGTC_2065 5221596 34.26 µM 0.904487384012789 0.133549924355776 no 485 0.18286851052819 201 788581
SGTC_1174 0739-0097 51.1 µM 0.903834247949306 0.133718025028984 no 486 0.183041649321668 211 728447
SGTC_873 0591-4978 488 µM 0.903381236442273 0.133834704114051 no 487 0.183161797465866 231 3305145
SGTC_2359 9039622 200 µM 0.903041453259184 0.133922265667233 no 488 0.183251947363719 226 6463596
SGTC_392 N-ethylmaleimide 8.33 µM 0.902797476555989 0.133985162330315 no 489 0.183316695338871 218 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2906 7926292 26.41 µM 0.901873125104735 0.134223642237501 no 490 0.18356213455402 196 2966319
SGTC_3185 9108267 49.47 µM 0.901474801032715 0.134326498487796 no 491 0.183667963007843 216 4910486
SGTC_1657 st012939 43.4 µM 0.900986294765241 0.134452715691097 no 492 0.183797803344509 188 24207257
SGTC_2953 9074162 66.49 µM 0.900787296792582 0.134504154879249 no 493 0.183850711505241 196 16451992
SGTC_21 0849-0113 22.993 µM 0.898426433541946 0.135115447765783 no 494 0.184479124623543 216 1560156
SGTC_1063 disulfiram 1.84 µM 0.892946077877162 0.136541798847033 no 495 0.185943024885562 229 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1238 0333-0287 48.8 µM 0.891780527824685 0.136846475199983 no 496 0.186255290366285 212 7226
SGTC_33 0986-0033 35.816 µM 0.890472052399117 0.137189065710816 no 497 0.186606234258982 184 2848082
SGTC_856 0433-0016 11.3 µM 0.888686787136201 0.137657435584643 no 498 0.187085717027296 202 3911780
SGTC_2327 6189656 200 µM 0.888303957893813 0.137758013958196 no 499 0.187188635639125 209 5349088
SGTC_274 sirtinol 40.1 µM 0.88806877984071 0.137819825700677 no 500 0.187251877526303 198 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3101 9120531 49.47 µM 0.887853830951539 0.137876337170193 no 501 0.187309691129738 220 24824904
SGTC_536 3852-0578 10.6 µM 0.887375714321464 0.138002093842339 no 502 0.187438327060372 207 2869208
SGTC_386 1509-0011 3.07 µM 0.882542697492471 0.139277690936506 no 503 0.188741700337987 204 3107280
SGTC_3242 9133940 49.47 µM 0.882118541155079 0.139390021896274 no 504 0.188856353307743 197 17248444
SGTC_566 0958-0068 16.5 µM 0.880831633289794 0.139731215772638 no 505 0.189204477713256 229 6815365
SGTC_36 0335-0881 14.2 µM 0.880225378416744 0.139892146824401 no 506 0.189368613937519 213 23828853
SGTC_449 xestospongin c 11.1929 µM 0.879578674375309 0.140063953963167 no 507 0.189543797864371 218 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1961 st076550 68.7 µM 0.879173975088704 0.140171541616929 no 508 0.189653476477899 226 1579337
SGTC_3260 9137109 49.47 µM 0.879022056786314 0.140211942965963 no 509 0.189694658330886 211 17478346
SGTC_2478 5763493 32.33 µM 0.878930902552505 0.140236188436804 no 510 0.189719370964362 220 1365576 YLR208W SEC13
SGTC_364 0083-0097 67.7 µM 0.876140496962305 0.140979766690402 no 511 0.190476829787571 213 5207356
SGTC_2634 4'-methoxyflavone 100 µM 0.873822697343227 0.141599436102491 no 512 0.191107408879801 184 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1725 st036284 20.55 µM 0.873734506241809 0.141623050595381 no 513 0.191131427347243 206 707914
SGTC_1979 st071809 45.3 µM 0.873537191872586 0.141675894144908 no 514 0.191185171770471 222 4976333
SGTC_2239 6685329 187.64 µM 0.871990322206144 0.142090630261103 no 515 0.191606828587346 188 805680
SGTC_156 3474-0145 5.642 µM 0.869181567328314 0.142845793313501 no 516 0.192373913884324 202 2265471
SGTC_32 0928-0142 34.1 µM 0.867233654547702 0.143371100166914 no 517 0.19290699996291 229 2244242
SGTC_1742 st038235 28.8875 µM 0.867015143177681 0.143430108875344 no 518 0.192966856290744 232 564103 YBR002C RER2
SGTC_1012 4112-3522 18 µM 0.865807590091315 0.143756502668633 no 519 0.193297843082975 207 3112398
SGTC_2740 felodipine 17.08 µM 0.862407511699199 0.144678212354425 no 520 0.194231654194629 181 3333 L-type calcium channel blocker
SGTC_2839 9003951 25.97 µM 0.858985060443358 0.145609998506866 no 521 0.195174379184293 206 2990634
SGTC_889 0919-1524 82.7 µM 0.858676871764432 0.145694102608413 no 522 0.195259406991017 201 3905452
SGTC_969 1313-0238 134 µM 0.85601013975631 0.146423212446258 no 523 0.195996085425103 244 5212874
SGTC_1407 3909-7909 12.3 µM 0.852731652616744 0.147322933434515 no 524 0.196904066820523 210 4411780
SGTC_3107 9121808 49.47 µM 0.852029550830843 0.147516093143331 no 525 0.197098845415623 193 662681
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.851877200189629 0.147558029694652 no 526 0.197141126250355 191 521171
SGTC_3246 9135460 32.98 µM 0.848764653955922 0.148416548005557 no 527 0.198006130924329 223 41446951
SGTC_3270 9137563 49.47 µM 0.848639250678621 0.148451207241189 no 528 0.198041029594598 207 17015724
SGTC_1527 coumarin 137 µM 0.848230677476882 0.148564167151719 no 529 0.198154757820104 237 323 A hepatotoxic, DNA x-linker.
SGTC_2566 crystal violet carbinol 226 nM 0.846530286001921 0.149034898521711 no 530 0.198628492953559 259 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_3176 9106582 49.47 µM 0.846286532453974 0.149102460098859 no 531 0.19869645949415 175 17018027
SGTC_848 0368-0089 85.6 µM 0.843845036068895 0.149780302247571 no 532 0.19937800274193 226 762535
SGTC_2208 7283366 200 µM 0.842959624233306 0.150026629695313 no 533 0.199625512646539 229 898663
SGTC_70 0141-0289 43.283 µM 0.842339765752485 0.150199239085527 no 534 0.199798899180612 226 352408
SGTC_1195 1502-0147 41.1 µM 0.84068600000224 0.150660403733714 no 535 0.200261932820066 207 817940
SGTC_3323 9138564 53.9225 µM 0.840324753233926 0.15076126537977 no 536 0.200363163119613 227 43912313 YNL103W MET4
SGTC_2493 resveratrol 26.09 µM 0.839667719195636 0.150944827318145 no 537 0.200547359127131 195 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2812 7970281 58.44 µM 0.836722336245567 0.151769534825181 no 538 0.201374330458534 219 2233435
SGTC_865 0488-0499 301 µM 0.836549916598986 0.151817904937321 no 539 0.201422803741207 216 9634651
SGTC_421 streptovitacin 30 mM 0.836505387419431 0.151830398689501 no 540 0.201435323610242 223 91467 include heat shock
SGTC_1897 st060201 15 µM 0.834696292268571 0.152338562329397 no 541 0.201944364896869 218 611878
SGTC_818 4072-2707 53.5 µM 0.834333776330906 0.152440526436889 no 542 0.202046461783686 217 882871
SGTC_1495 4469-0029 237 µM 0.833680374192088 0.152624421867645 no 543 0.202230560171874 224 793680
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.832820663971139 0.152866605379027 no 544 0.202472939415928 203 77254
SGTC_688 0527-0193 473 µM 0.832425325673559 0.152978059111347 no 545 0.202584455941015 271 4007154
SGTC_396 dithiazanine 1.25 µM 0.831630150367106 0.153202397967539 no 546 0.202808869137969 196 10578 An antihelmenthic.
SGTC_550 4123-0385 25.7 µM 0.831592308204111 0.153213079620581 no 547 0.202819552597985 222 5731123
SGTC_3168 9103419 49.47 µM 0.829271353426245 0.153869155579294 no 548 0.203475438475428 224 16649256
SGTC_1467 k284-1082 293 µM 0.827022346692182 0.15450666482153 no 549 0.204112197791336 235 3334705
SGTC_2925 9010536 32.5 µM 0.826929468946266 0.154533029672886 no 550 0.204138519682561 212 2994177
SGTC_2021 4019055 173 µM 0.826727614739623 0.154590339509926 no 551 0.204195732870775 253 44827708 YER133W GLC7
SGTC_3315 9136395 68.55 µM 0.825321171650482 0.154990042446293 no 552 0.204594637536729 258 16876844
SGTC_452 diindolylmethane 8 µM 0.82427238113785 0.155288546432451 no 553 0.204892403993592 219 3071 Inhibits expression of several cancer promoting factors.
SGTC_1492 4158-0558 28.5 µM 0.824113057576208 0.155333925860752 no 554 0.204937660740432 205 3967268
SGTC_2894 9048625 32.47 µM 0.820007662865345 0.156506265338072 no 555 0.206105869397442 248 4092861
SGTC_1251 0490-5699 265 µM 0.818468491610766 0.156947289845346 no 556 0.206544863212783 240 3883818
SGTC_3306 9127676 59.7925 µM 0.81746041874056 0.157236579408756 no 557 0.206832680041301 219 41905287
SGTC_2598 perillyl alcohol 100 µM 0.815725412615561 0.157735299563909 no 558 0.207328600551741 214 10819 An apoptosis inducer.
SGTC_1501 4491-0275 38.4 µM 0.815233131270936 0.157876992774201 no 559 0.207469438317947 236 5104718
SGTC_913 3487-1245 167 µM 0.814716023884301 0.158025921643033 no 560 0.207617439497848 231 4016153
SGTC_289 k017-0060 526 µM 0.814372094541084 0.15812502563861 no 561 0.207715909966402 232 5512909
SGTC_3096 9117468 49.47 µM 0.812562871951072 0.15864702868891 no 562 0.20823436291132 227 41316311
SGTC_3245 9134821 49.47 µM 0.811710587840027 0.158893323662121 no 563 0.208478858766705 251 17014901
SGTC_897 1000-0139 31.4 µM 0.810367388275939 0.159281992885625 no 564 0.208864527617678 238 6151020
SGTC_2425 5628681 7.85 µM 0.809244705423335 0.159607330499394 no 565 0.209187202427698 248 5714958
SGTC_1482 3346-2049 8.48 µM 0.809079534138566 0.159655231473741 no 566 0.209234699725608 219 3826804
SGTC_2891 9063876 19.48 µM 0.808715769560866 0.159760759238785 no 567 0.209339327668157 210 6472478
SGTC_2373 9071805 200 µM 0.80744944825954 0.160128473729927 no 568 0.209703793954841 243 10149009
SGTC_981 1488-1094 54.9 µM 0.805149975244283 0.160797608431084 no 569 0.210366569924426 234 3449522
SGTC_2834 9001755 58.44 µM 0.80475257743218 0.160913433884065 no 570 0.21048123620601 230 2989575
SGTC_1112 tnp00069 1.16933 µM 0.802956230864379 0.161437675857147 no 571 0.211000016601953 224 145826
SGTC_1494 4358-1428 177 µM 0.802582150562152 0.161546986616618 no 572 0.211108144283366 216 1564571
SGTC_1796 st049173 110.4 µM 0.800001277148433 0.16230246341035 no 573 0.211855028604473 249 94134
SGTC_2279 7948423 32.93 µM 0.799814441599512 0.162357243299158 no 574 0.211909157274305 216 1247112
SGTC_284 0988-0104 32.6 µM 0.799552224788564 0.162434145150538 no 575 0.211985138511693 252 4666532
SGTC_910 3454-3003 490 µM 0.799070361040916 0.162575525936481 no 576 0.212124807266869 249 820824
SGTC_1287 0971-0001 34.6 µM 0.798817295403538 0.16264980848074 no 577 0.212198180172682 230 4665869
SGTC_2899 9053889 58.44 µM 0.798554837026273 0.162726871402955 no 578 0.212274292044551 226 6470052
SGTC_1552 6-methylflavone 10.6 µM 0.797495828028852 0.163038058389265 no 579 0.212581562424325 235 689013
SGTC_939 1165-0479 45.3 µM 0.796417073981052 0.163355444852367 no 580 0.2128948287318 247 1377347
SGTC_470 aa-861 153 µM 0.796052197606474 0.163462888017625 no 581 0.2130008484676 238 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1090 efavirenz 20.7 µM 0.795088274173751 0.163746950050437 no 582 0.213281077521191 233 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_193 1273-0060 1.558 µM 0.7906514064236 0.165058595516444 no 583 0.214573719973883 239 2847393 YHR072W ERG7
SGTC_1889 st059080 5.18 µM 0.790240065858831 0.165180541342885 no 584 0.214693790673092 227 176925 Isolated from Daphnopsis sellowiana.
SGTC_501 nsc-95397 161 µM 0.789130646717317 0.165509729863353 no 585 0.215017825768126 252 262093
SGTC_2251 lansoprazole 556 µM 0.789112902350235 0.165514998444215 no 586 0.215023010784487 222 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1732 st034308 51.822 µM 0.788308930215852 0.16575382418116 no 587 0.215258012687429 220 830119
SGTC_39 0986-0283 58.349 µM 0.787674566094771 0.165942423801689 no 588 0.215443543147891 215 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2463 5473429 200 µM 0.787340286387622 0.166041862601191 no 589 0.215541346180116 233 5399405
SGTC_100 0086-0128 49.5915 µM 0.787064975803999 0.166123788653956 no 590 0.215621915451603 270 93297
SGTC_1395 3486-0190 4.35 µM 0.786873664087315 0.166180733965423 no 591 0.215677912850042 240 6748079
SGTC_2334 9017922 200 µM 0.786109198119258 0.166408408615698 no 592 0.215901758014107 242 3163164
SGTC_2594 a-mangostin 100 µM 0.786046053576939 0.166427223439143 no 593 0.215920253540214 249 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1716 st033144 30.6155 µM 0.786025145738415 0.166433453532631 no 594 0.215926377810562 246 674617
SGTC_2716 st080858 38.6235 µM 0.784221879462459 0.166971355232175 no 595 0.216454964513732 236 5296050
SGTC_529 4076-0302 30.3 µM 0.784022157245716 0.167030999860973 no 596 0.216513554586828 248 5816522
SGTC_2073 5212005 126 µM 0.783938896865553 0.167055868625526 no 597 0.216537982379818 252 691789
SGTC_987 1497-1013 404 µM 0.782231695298495 0.167566313279925 no 598 0.217039210299837 235 1676435
SGTC_779 1360-0071 233 µM 0.780894280924851 0.167966894505057 no 599 0.217432338018369 247 7566
SGTC_1663 st014140 55.4 µM 0.780712992374019 0.168021241297778 no 600 0.217485658699633 231 4207120
SGTC_80 0159-0065 512.242 µM 0.780287610809958 0.1681488068687 no 601 0.217610801772711 230 1548079
SGTC_3149 9097855 49.47 µM 0.780024819747075 0.168227645110478 no 602 0.217688133080037 221 25236625 YMR079W SEC14
SGTC_2960 9079389 5.97 µM 0.778819309714672 0.168589607036349 no 603 0.218043080648932 222 16457355
SGTC_549 1661-1316 519 µM 0.778565961487699 0.168665740042113 no 604 0.218117718315155 253 2857282
SGTC_555 4296-0685 37 µM 0.775609859797676 0.169555703109192 no 605 0.218989688467908 266 2908540 YHR072W ERG7
SGTC_171 k064-0041 9.68 µM 0.774450589690572 0.169905533533278 no 606 0.219332188375482 233 53325
SGTC_2162 5663267 200 µM 0.771557041505107 0.170780730655765 no 607 0.220188412912038 249 6456493
SGTC_1203 3992-3522 103 µM 0.769695162746513 0.171345406645058 no 608 0.220740370083687 260 5322312
SGTC_174 3553-0389 74.3 µM 0.769153311070348 0.17150996495317 no 609 0.22090115168611 237 738071
SGTC_3250 9135583 49.47 µM 0.767571586503275 0.171990906204098 no 610 0.221370874154102 232 7699353
SGTC_403 arphamenine a 50 µM 0.767323628058757 0.172066378765358 no 611 0.221444561767742 256 5487158 An arginine aminopeptidase inhibitor.
SGTC_1230 0170-0365 3.77 µM 0.767289573724433 0.172076745732967 no 612 0.221454683036975 246 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1673 st016611 27.3 µM 0.7669432318559 0.172182203266678 no 613 0.221557634127236 268 5226799
SGTC_63 0099-0242 26.702 µM 0.765039435895584 0.172762625789444 no 614 0.222124031038172 264 3898502 YLR359W ADE13
SGTC_3205 9113483 49.47 µM 0.764849066982312 0.172820733294936 no 615 0.222180712967356 253 17018033
SGTC_110 0850-0284 111.64 µM 0.764643476971088 0.172883500820219 no 616 0.222241936215234 227 3906265
SGTC_400 oxethazaine 37.5 µM 0.763762832263095 0.173152529844239 no 617 0.222504294871461 250 4621 A local anesthetic.
SGTC_1791 st048313 56.1 µM 0.761243483078949 0.173923639845518 no 618 0.223255825308626 220 1204976
SGTC_1571 st070080 73.4 µM 0.759918342247199 0.1743301074159 no 619 0.223651698443911 249 4315245
SGTC_3266 9136860 49.47 µM 0.75980031790101 0.174366338906344 no 620 0.223686976435178 247 4871271 YPR165W RHO1
SGTC_1526 st051518 75 µM 0.757491254967063 0.175076144580114 no 621 0.224377801564524 235 673993
SGTC_1952 st077036 64.1 µM 0.755200921894421 0.17578200077989 no 622 0.22506421780143 241 2937007
SGTC_2918 7977171 22.06 µM 0.753898566563023 0.176184175624321 no 623 0.225455065699034 254 2236483
SGTC_710 3448-4187 58 µM 0.75370792148577 0.176243096752877 no 624 0.225512312128089 242 3946412
SGTC_2427 5545055 42.75 µM 0.753517781514255 0.176301874191768 no 625 0.225569415078958 253 5372858
SGTC_2871 9038510 12.99 µM 0.753346807839029 0.176354737397109 no 626 0.225620768982588 274 4945164
SGTC_2333 9017922 200 µM 0.752862843502448 0.176504428284241 no 627 0.225766169081096 262 3163164
SGTC_3197 9113331 49.47 µM 0.751618563893721 0.176889654605108 no 628 0.226140238134275 238 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2258 7960471 200 µM 0.748708820715629 0.177792577246793 no 629 0.227016363008478 254 2974708
SGTC_698 k064-0052 127 µM 0.747190177658652 0.178264980119156 no 630 0.227474386139494 283 5088751
SGTC_115 0527-0192 112.043 µM 0.746251553513561 0.178557352220492 no 631 0.227757735479289 279 4233931
SGTC_1938 st074717 56.4 µM 0.744792492962249 0.179012434323352 no 632 0.228198586912884 236 17250979
SGTC_3126 9127922 49.47 µM 0.743227495069087 0.179501368795974 no 633 0.228671979833386 283 45595682
SGTC_2149 5554786 194.827 µM 0.742682873777545 0.179671715325827 no 634 0.228836850434977 247 745063 YPR165W RHO1
SGTC_1976 st070609 63.5 µM 0.74145654138041 0.180055659033926 no 635 0.229208336337582 243 682556
SGTC_1405 3909-7894 12 µM 0.740783581384148 0.180266570036763 no 636 0.22941233590484 258 7104060
SGTC_2619 obliquin 87.91 µM 0.74070028884489 0.180292685357677 no 637 0.229437592091448 254 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2201 6605497 169.863 µM 0.739439790505821 0.180688188439765 no 638 0.229819993947168 250 670741
SGTC_182 3448-4371 550.524 µM 0.738066646422726 0.181119654647508 no 639 0.230236975345639 223 3491403
SGTC_2141 5621638 7.665 µM 0.737850514788439 0.181187625779922 no 640 0.230302646361721 257 2856238
SGTC_20 0481-0013 4.944 µM 0.734135041005435 0.18235860047315 no 641 0.231433219516883 259 182045
SGTC_2235 salicylic acid 500 µM 0.733817412613025 0.182458923664668 no 642 0.231530013325941 254 338 A COX inhibitor and kinase inhibitor.
SGTC_1247 0448-0043 5.84 µM 0.733620321475243 0.182521192394875 no 643 0.231590086057948 258 3089013 YGL099W LSG1
SGTC_2957 9076800 11.52 µM 0.732367561295576 0.182917298143438 no 644 0.231972126287929 265 16459615
SGTC_603 3794-0023 45.9 µM 0.732124643934447 0.182994167364574 no 645 0.232046246672959 275 3802260
SGTC_319 1348-1596 45.5 µM 0.731640499108573 0.183147431161452 no 646 0.232194011130368 255 5380505
SGTC_3262 9137218 49.47 µM 0.731541173394582 0.183178884202222 no 647 0.232224332519665 224 17650664
SGTC_2257 7960413 200 µM 0.73008901943506 0.183639116098688 no 648 0.23266788640554 256 2974689 YIL048W NEO1
SGTC_2757 clomiphene 4.22 µM 0.728678538226061 0.184086829783032 no 649 0.233099161987777 286 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2743 auranofin 4.32 µM 0.728207395270094 0.184236530827316 no 650 0.233243319775588 221 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2376 9072922 81.32 µM 0.727795517076629 0.184367463122436 no 651 0.233369384575793 265 17087968
SGTC_562 3772-2733 112 µM 0.727491977268007 0.184463992683361 no 652 0.233462314111057 255 2876874 YIL048W NEO1
SGTC_2707 st078556 66.6 µM 0.726802391680303 0.18468340657315 no 653 0.233673508875751 249 17250899
SGTC_2133 5320837 200 µM 0.726605752019025 0.184746003542221 no 654 0.233733751791545 247 2841355
SGTC_2270 7924575 90.91 µM 0.72414358795545 0.18553090869752 no 655 0.234488793570465 255 1262135
SGTC_1971 st069429 63.5 µM 0.723304728445399 0.185798797925339 no 656 0.234746344212126 261 1246522 YGL099W LSG1
SGTC_1477 0139-0234 16 µM 0.720324863686052 0.186752354189374 no 657 0.235662499781093 259 620880
SGTC_1347 1493-0251 600 nM 0.720003591092686 0.186855341965963 no 658 0.235761392258271 256 3986378
SGTC_3225 9130819 49.47 µM 0.719684394459471 0.186957699068928 no 659 0.235859668381012 290 4547121
SGTC_1283 0922-0125 16.4 µM 0.718925326289911 0.18720124952422 no 660 0.236093465400881 244 3360884
SGTC_1457 k015-0032 57.3 µM 0.717449392509311 0.187675370871117 no 661 0.236548426091651 274 4302660
SGTC_129 0088-0017 176.636 µM 0.714232997197947 0.188711155910633 no 662 0.237541557998022 258 182446
SGTC_2182 6325192 200 µM 0.713568236858975 0.188925669163005 no 663 0.237747102177361 248 736248
SGTC_297 0986-0032 24 µM 0.71349137022891 0.188950483143305 no 664 0.237770875663202 260 2847425
SGTC_545 4218-0007 221 µM 0.710477386713556 0.18992503549365 no 665 0.238704074517453 277 2840508
SGTC_2138 5575593 77.673 µM 0.710179192827313 0.190021622286739 no 666 0.238796511045458 266 762213
SGTC_1223 0764-0573 147 µM 0.710105094152072 0.19004562797567 no 667 0.238819483783005 254 1609797
SGTC_1832 st054113 55 µM 0.709101775278732 0.190370855850506 no 668 0.23913066069077 255 1251267
SGTC_2689 tacrolimus 100 µM 0.705655640845865 0.191490528420908 no 669 0.240201156645185 258 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_875 0709-0210 25.7 µM 0.705405838772642 0.191571847350437 no 670 0.240278855735548 271 6251364
SGTC_1187 1391-0724 117 µM 0.705097969108922 0.191672098319384 no 671 0.240374635157955 263 6997986
SGTC_1 0258-0098 57.368 µM 0.703429218356532 0.1922160490774 no 672 0.240894151556784 245 6790032 YDR047W HEM12
SGTC_1914 st062367 72.6 µM 0.703210202519784 0.192287510138715 no 673 0.240962381000612 274 978205
SGTC_1322 1348-1070 12 µM 0.702316276512785 0.19257935113051 no 674 0.241240972450152 269 6758089
SGTC_1828 st055811 49 µM 0.701939636107771 0.192702394353482 no 675 0.241358404577804 274 5877589
SGTC_3124 9127567 49.47 µM 0.701800928977314 0.192747720159599 no 676 0.241401659682534 247 17592030
SGTC_2714 st079313 56.9 µM 0.700441377549027 0.193192330202484 no 677 0.24182585164059 271 2939799
SGTC_1053 3366-3204 134 µM 0.699899321057754 0.193369771731963 no 678 0.241995090726549 284 3632071 YPR165W RHO1
SGTC_1352 1496-0991 99 µM 0.696575037942497 0.194460145205605 no 679 0.243034391026103 276 3000039
SGTC_2267 7931562 200 µM 0.691926861388954 0.195991019403991 no 680 0.244491630410996 259 934880
SGTC_3058 9093861 49.47 µM 0.690496670927371 0.196463518694587 no 681 0.24494095137478 276 17217477
SGTC_3333 9141820 12.094 µM 0.689901066320348 0.196660495046028 no 682 0.24512820261689 265 1939433
SGTC_758 0868-0029 16 µM 0.689712425439231 0.196722906659636 no 683 0.24518752519043 252 762687
SGTC_1987 st072290 61.9 µM 0.689273028285381 0.196868327198057 no 684 0.245325733914389 275 54697379
SGTC_1692 fluoroquinolonic acid 71 µM 0.689200397104868 0.196892371093073 no 685 0.245348583481147 280 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3339 9145883 14.936 µM 0.689045902881329 0.196943520920227 no 686 0.245397190736939 262 2030670
SGTC_373 0844-0104 25.9 µM 0.68859707557879 0.197092163937492 no 687 0.245538430956737 270 5375804
SGTC_360 0957-0399 1.01 µM 0.688508050033819 0.197121655561879 no 688 0.245566451347914 276 6752301 YPR165W RHO1
SGTC_1323 1348-1351 11.2 µM 0.688261674461566 0.197203286683387 no 689 0.245644005908354 264 6989654
SGTC_1548 st061468 90.8 µM 0.687012846700829 0.197617372747864 no 690 0.246037316468962 274 390799
SGTC_1755 st041960 45.185 µM 0.686121560960049 0.197913226251875 no 691 0.246318227852744 286 2257073
SGTC_2861 9024595 19.48 µM 0.685940224493391 0.197973451840538 no 692 0.246375401696144 247 16482810
SGTC_1520 flindersine 88 µM 0.685593409213161 0.198088667188496 no 693 0.24648476940769 277 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1783 st039459 87.517 µM 0.684956904058932 0.198300225590637 no 694 0.246685558075984 301 729761
SGTC_2069 5228469 200 µM 0.684840566409367 0.198338908051886 no 695 0.246722266822922 289 2835210
SGTC_3040 9091894 49.47 µM 0.683071749718775 0.198927603323825 no 696 0.247280752766457 240 25236966
SGTC_45 0kpi-0036 14.9 µM 0.682333436062444 0.199173639113778 no 697 0.247514067605593 279 2795021
SGTC_2005 4024620 188 µM 0.680739342188868 0.1997054800123 no 698 0.248018218811446 282 236743
SGTC_1028 k015-0029 4.8 µM 0.680146639563834 0.199903442335182 no 699 0.248205807722395 283 4588309
SGTC_133 0724-0033 378.92 µM 0.679104074463022 0.200251944681021 no 700 0.248535960506027 268 280309
SGTC_420 mitomycin C 81.9 mM 0.679021405423257 0.200279594400219 no 701 0.248562149612169 271 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2353 9059630 146.67 µM 0.678751234829979 0.200369972412745 no 702 0.248647748452349 271 4779114
SGTC_2920 7982904 15.77 µM 0.6784133344468 0.200483042008365 no 703 0.248754828389684 266 6456808
SGTC_2341 7987486 176.74 µM 0.677399220975878 0.200822618782605 no 704 0.24907634624032 263 1258686
SGTC_1690 st023502 41.2 µM 0.675623224477303 0.201418143671033 no 705 0.249639946155941 282 24207482
SGTC_1686 st019653 115.5 µM 0.675440184080145 0.201479580648414 no 706 0.249698071210483 300 97252
SGTC_2458 5808907 16.39 µM 0.674672728624006 0.201737297063856 no 707 0.249941857330597 289 2731747
SGTC_27 0485-0001 32.618 µM 0.674666127478618 0.201739514626402 no 708 0.249943954765715 270 2054479
SGTC_2273 7815444 169.05 µM 0.672442231419989 0.202487432072282 no 709 0.250651102537114 313 2824616
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.672202983704949 0.202567992005778 no 710 0.2507272408887 309 5393153
SGTC_587 k089-0003 57 µM 0.672181070099161 0.202575371753336 no 711 0.250734215301369 279 9659696
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.67198276380572 0.202642161788948 no 712 0.250797334639231 285 1273210
SGTC_1460 k062-0059 9.15 µM 0.671599840319168 0.202771168575507 no 713 0.250919239984103 268 1373085
SGTC_1581 himbacine 57.9 µM 0.671457635516331 0.202819089815584 no 714 0.250964519481567 297 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1357 1503-1303 39.5 µM 0.671094844120331 0.202941376623749 no 715 0.251080055643481 267 292895
SGTC_62 0180-0423 3.232 µM 0.67014260195698 0.203262560172772 no 716 0.251383444727029 303 30102 YGL099W LSG1
SGTC_3213 9129884 49.47 µM 0.668995000985463 0.203650039507121 no 717 0.251749333422802 273 17190742
SGTC_3214 9129694 49.47 µM 0.667948321590766 0.204003827148443 no 718 0.252083290412483 291 17158655
SGTC_209 4077-0173 175.592 µM 0.666577978346211 0.204467569401752 no 719 0.252520869691537 264 15993494
SGTC_3013 9080133 71.4286 µM 0.665217711231487 0.204928521708651 no 720 0.252955626938068 289 17050193
SGTC_792 4534-1957 155 µM 0.664630854423678 0.20512757989004 no 721 0.253143314778379 281 1717904
SGTC_1798 st045719 60.953 µM 0.664320542038261 0.205232882349457 no 722 0.253242588110151 273 3980186
SGTC_3288 9119690 36.221 µM 0.663642862450607 0.205462960070854 no 723 0.253459458565929 299 17595618 YKL019W RAM2
SGTC_3329 9141233 27.5565 µM 0.663434050698167 0.205533884211973 no 724 0.253526301992264 287 4909101 YNL103W MET4
SGTC_3208 9114115 49.47 µM 0.661964351952129 0.206033487101369 no 725 0.253997034036868 285 650895
SGTC_216 k038-0035 28.382 µM 0.660809956100657 0.206426411852885 no 726 0.254367098555675 285 4444231 YPR107C YTH1
SGTC_1583 clindamycin 39.6 µM 0.658583057713728 0.207185640261094 no 727 0.255081772665197 293 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_929 2805-0021 398 µM 0.657681191432327 0.207493587650693 no 728 0.255371505362121 312 3098024
SGTC_512 prima-1 270 µM 0.65572917736338 0.208161039712505 no 729 0.255999196044592 273 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1351 1496-0003 46.5 µM 0.655137466950777 0.208363613193064 no 730 0.256189625609061 284 3891978
SGTC_2244 6635614 200 µM 0.654952893531808 0.208426826131366 no 731 0.256249041795667 291 836499
SGTC_389 tpck 16.7 µM 0.654337126942786 0.208637796443667 no 732 0.256447315692247 275 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1590 st077108 57.8 µM 0.654224008937946 0.208676565948126 no 733 0.25648374783764 256 5489485
SGTC_1591 genipin 88.4 µM 0.65409662716107 0.208720229229992 no 734 0.256524777172687 304 442424 A DNA cross-linking agent.
SGTC_1124 fisetin 1.16336 µM 0.64856678763961 0.210620905015305 no 735 0.258309214302645 289 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1951 sophoraflavanone G 9.2 µM 0.645740432951817 0.211596267835358 no 736 0.25922373531078 286 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2870 9038528 12.99 µM 0.644827838602628 0.211911764043071 no 737 0.259519379632231 289 6463316
SGTC_490 phenamil 164 µM 0.643380782989915 0.212412594443942 no 738 0.259988524868703 286 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_479 n-linoleoylglycine 10 µM 0.643351600650445 0.21242270165047 no 739 0.259997990477959 296 6433346 An anti-infammatory.
SGTC_312 4092-0653 6.84 µM 0.643337852355327 0.212427463424277 no 740 0.260002449948621 294 1148278
SGTC_1224 0823-0416 294 µM 0.641978995922633 0.212898416096565 no 741 0.260443410431423 294 3598164
SGTC_844 0330-0132 15.3 µM 0.638347847180662 0.214159885941187 no 742 0.261623636018228 291 2828079
SGTC_2352 9027995 87.8 µM 0.637953652473634 0.214297091345213 no 743 0.261751925365804 292 2997347
SGTC_85 0868-0259 160.055 µM 0.637773563152024 0.214359791157433 no 744 0.261810545570893 274 83173
SGTC_785 1270-0111 65.3 µM 0.636544621276011 0.214787943709431 no 745 0.262210753562003 284 6741994
SGTC_1360 1598-0022 39.8 µM 0.635730416251425 0.215071879012635 no 746 0.262476073971007 313 761525
SGTC_235 0330-0087 5 mM 0.634968134416114 0.215337904711735 no 747 0.262724598972831 287 46494818 YHR062C RPP1
SGTC_1354 1498-1681 81 µM 0.632631478820868 0.216154553494618 no 748 0.263487162779969 288 5754243
SGTC_3049 9092223 49.47 µM 0.630334906553973 0.216958938229284 no 749 0.264237744696875 287 8623917
SGTC_130 0136-0219 337.655 µM 0.629786882631639 0.217151141440634 no 750 0.264417014514813 333 234244
SGTC_632 0781-2353 4.65 µM 0.628941445735113 0.217447846321662 no 751 0.264693695552516 306 6811515 YHR007C ERG11
SGTC_2515 chrysin 20.77 µM 0.628672348986093 0.217542334524093 no 752 0.264781792103616 287 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_657 3534-0529 86.7 µM 0.627851674582205 0.217830645021366 no 753 0.265050555471209 307 1049549
SGTC_1041 0206-0046 107 µM 0.627803892607644 0.217847438056808 no 754 0.265066207899557 307 50494
SGTC_1630 st005209 31.3 µM 0.627747309855681 0.217867325102195 no 755 0.265084743895478 290 3367314
SGTC_3278 9139605 49.47 µM 0.627331269375607 0.218013582303629 no 756 0.265221055196186 299 7958859
SGTC_748 act1.228 77.9 µM 0.62532818409721 0.218718549987532 no 757 0.265877842883835 280 4421505 YNR035C ARC35
SGTC_3244 9134489 49.47 µM 0.624826252007677 0.21889540577908 no 758 0.266042549453796 319 16584271
SGTC_1899 st063254 59.6 µM 0.624285096798188 0.219086173970087 no 759 0.266220184775728 290 3093813
SGTC_2013 4024628 200 µM 0.624277432887949 0.219088876340303 no 760 0.266222700901299 314 5230760
SGTC_280 3448-3607 3.04 µM 0.623879887979053 0.219229080871461 no 761 0.266353234712339 286 626179
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.622627324420076 0.219671167018851 no 762 0.266764725435276 311 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1731 st035964 63 µM 0.62257932107392 0.219688119742492 no 763 0.266780501828737 308 6739575
SGTC_940 3232-1287 54.8 µM 0.62237480048096 0.219760356064478 no 764 0.266847723204564 301 1585493 YIL048W NEO1
SGTC_369 0957-0393 4.5 µM 0.620372598012956 0.220468250326687 no 765 0.267506254348165 300 6997992
SGTC_533 1222-0222 6.71 µM 0.619169289384162 0.220894317392262 no 766 0.267902420481013 314 3982874
SGTC_3255 9139072 49.47 µM 0.619064598904142 0.220931408434835 no 767 0.267936901767587 295 17646060
SGTC_1714 st033236 13.627 µM 0.617920384992705 0.221337027094704 no 768 0.268313910402625 305 2916566
SGTC_2000 st075254 36.4 µM 0.616910713362137 0.221695304558783 no 769 0.268646809987988 280 17234175
SGTC_706 4262-0057 46.9 µM 0.613312259194644 0.222974891537636 no 770 0.269834944471864 310 883298
SGTC_2997 9067075 71.4286 µM 0.612976825084838 0.223094383694701 no 771 0.269945831718857 305 27209819
SGTC_1420 4'-methoxyflavone 42 µM 0.612842091180014 0.223142390402509 no 772 0.26999037824714 296 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2429 5902844 64.44 µM 0.61193312578501 0.223466415280404 no 773 0.270291001905471 307 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_244 nsc-207895 1.295 µM 0.611508042301017 0.22361803939943 no 774 0.270431647893239 276 42640
SGTC_2643 anethole 100 µM 0.610519240205466 0.223970963987271 no 775 0.270758951045431 325 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_712 r015-0009 80.6 µM 0.607905887479657 0.224905247337228 no 776 0.271624947278813 313 6813872 YLR060W FRS1
SGTC_2057 5236571 38.335 µM 0.607881981882035 0.224913803862027 no 777 0.271632875324744 312 54684039 YBR257W POP4
SGTC_2480 5767542 37.17 µM 0.607766510269116 0.224955137186894 no 778 0.271671171921456 303 2867358
SGTC_2646 retinol 96.75 µM 0.607625352223522 0.225005670876323 no 779 0.271717991171648 307 445354 A vitamin A analog and teratogen.
SGTC_2418 pentamidine 31.67 µM 0.605645041155313 0.225715287598726 no 780 0.272375243133864 284 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2950 9072895 21.46 µM 0.605297218760237 0.225840055464261 no 781 0.272490764535635 274 17332245
SGTC_1182 1222-0449 220 µM 0.605214580228608 0.225869704582622 no 782 0.272518214645521 305 658318
SGTC_1056 3448-1962 115 µM 0.604369664172628 0.22617297051315 no 783 0.272798949872608 306 715507
SGTC_2842 9000675 19.48 µM 0.604177149911427 0.226242101876198 no 784 0.272862935502534 291 2989072
SGTC_1408 3909-7976 48.8 µM 0.603958689437162 0.226320564913901 no 785 0.272935553845082 303 24152374
SGTC_821 1114-0266 29.2 µM 0.603892308667347 0.226344409510819 no 786 0.272957621343491 304 3123235
SGTC_814 3342-0569 96 µM 0.602050625694193 0.227006524903301 no 787 0.273570219492962 310 4346283
SGTC_2337 9009472 200 µM 0.60094026355323 0.22740624555901 no 788 0.273939887211181 313 5742383
SGTC_318 1488-0629 67.2 µM 0.600119942611073 0.227701808408107 no 789 0.274213151359344 328 3662576
SGTC_1489 4065-0444 182 µM 0.599721878049519 0.227845309546736 no 790 0.274345802558472 307 2877968
SGTC_2206 7254556 146.969 µM 0.599320815267048 0.227989942986652 no 791 0.274479484916004 293 4398905
SGTC_2799 7812892 81.82 µM 0.598990218060336 0.228109203568093 no 792 0.274589703832001 312 20205235
SGTC_51 1013-0126 23.419 µM 0.598488446895998 0.228290280943194 no 793 0.274757032714786 307 1627850
SGTC_385 1494-0393 12.4 µM 0.598037197901266 0.228453195037064 no 794 0.274907556564414 300 3090647
SGTC_958 1222-0007 33 µM 0.596945616985837 0.228847557688422 no 795 0.275271844923552 317 7312461
SGTC_1851 st056236 18.9 µM 0.595868222061584 0.229237169673142 no 796 0.275631631901337 286 5393171
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.593329992354154 0.230156523421092 no 797 0.276480165257274 312 442882
SGTC_645 0845-0943 5.41 µM 0.592955994576769 0.230292160574636 no 798 0.27660530136569 301 1885106
SGTC_251 melphalan 456.522 µM 0.592336599012523 0.230516894025551 no 799 0.276812606284267 321 460612 A DNA alkylator.
SGTC_1811 st050069 61.5 µM 0.59097852473534 0.231010068821181 no 800 0.277267405066471 308 3877702
SGTC_2569 tetrandrine 100 µM 0.589764164269875 0.231451553316858 no 801 0.277674385502631 278 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1080 nisoldipine 24.4 µM 0.589268711596428 0.231631811698773 no 802 0.277840515148262 320 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_126 0417-1624 672.48 µM 0.589182685219631 0.231663118269694 no 803 0.27786936549354 338 41912 YDL195W SEC31
SGTC_1185 1319-0113 81.3 µM 0.587074911198381 0.232430912007253 no 804 0.278576698315425 318 4672763
SGTC_2745 rifampicin 24.3 µM 0.587020643894433 0.232450698497179 no 805 0.278594921065699 289 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1680 diphenhydramine 100 µM 0.584764712641098 0.233274065665639 no 806 0.279352967279343 304 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2004 4023728 41.89 µM 0.584702990564663 0.233296615641901 no 807 0.27937372143082 328 360084 YDR527W RBA50
SGTC_937 3122-0005 46.7 µM 0.584649021934152 0.2333163339111 no 808 0.27939186908692 302 759535
SGTC_3114 9122766 49.47 µM 0.583998359365415 0.233554136261391 no 809 0.279610707922364 275 17176985
SGTC_397 arbidol 50 µM 0.582628592253558 0.234055193995053 no 810 0.280071676612178 298 131410 A RNA synthesis inhibitor.
SGTC_1004 4084-0029 199 µM 0.582412355685845 0.234134347221773 no 811 0.280144480506228 315 716894 YLR208W SEC13
SGTC_2440 5628896 157.78 µM 0.581857946444084 0.234337355996029 no 812 0.280331184400515 320 5522048
SGTC_1253 0550-0034 176 µM 0.580835734273482 0.234711916063167 no 813 0.280675584381079 294 5969915
SGTC_1790 st045711 43.5 µM 0.580082424438792 0.234988156371997 no 814 0.280929517695255 275 585119
SGTC_2367 9070478 135.38 µM 0.577781032407805 0.235833193316662 no 815 0.281705981320268 298 572802
SGTC_1984 st072354 53.1 µM 0.577269353638084 0.23602130154206 no 816 0.281878756430933 314 5762938
SGTC_1567 st069303 68.4 µM 0.576908600747731 0.236153974635187 no 817 0.282000600100867 330 5581319
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.576574354758854 0.236276936013252 no 818 0.282113513744753 307 140250 A respiratory chain inhibitor.
SGTC_1679 SEC14.276 6.7 µM 0.575728336609422 0.236588324039616 no 819 0.282399409448732 327 1005053 YMR079W SEC14
SGTC_1270 0831-1170 17.3 µM 0.575481011599551 0.236679397873135 no 820 0.282483014538095 313 6764716
SGTC_1877 wortmannin 25 µM 0.57541509808625 0.236703672818858 no 821 0.282505297775567 326 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2286 7945697 125 µM 0.575131661184406 0.236808073928799 no 822 0.282601128300284 308 1245733
SGTC_2103 5378138 10 µM 0.575092397381715 0.236822538349082 no 823 0.282614404694496 317 244142
SGTC_2934 9036370 36.88 µM 0.574310979666934 0.237110506399556 no 824 0.282878690281468 316 6462800
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.573577451198507 0.237381001284114 no 825 0.283126887056469 315 15053
SGTC_2843 9000894 45.46 µM 0.571819010582715 0.238030130646043 no 826 0.283722298358064 256 2242070
SGTC_2813 7971799 71.43 µM 0.570725217575854 0.238434395280639 no 827 0.284092960980915 320 2234054
SGTC_1138 3761-0006 1.03 µM 0.569567286625453 0.238862774558011 no 828 0.284485610766099 307 12061087
SGTC_2186 6124449 200 µM 0.568850088275252 0.239128314729859 no 829 0.284728939812739 310 3834182 YLR033W RSC58
SGTC_2088 5278280 127.392 µM 0.568674367936853 0.239193399166836 no 830 0.28478857286418 315 791502
SGTC_2610 ononetin 44.17 µM 0.567215381744475 0.239734161584229 no 831 0.285283929411554 308 259632
SGTC_2147 5545932 89.7195 µM 0.565731769021516 0.240284735018975 no 832 0.285788067729113 336 797404
SGTC_1302 1159-0335 255 µM 0.565617529895979 0.240327158073107 no 833 0.28582690426328 315 649284
SGTC_3152 9099253 49.47 µM 0.565546862504902 0.240353402670979 no 834 0.285850929482834 303 25236131
SGTC_2436 5633522 8.09 µM 0.56544947716535 0.240389572392503 no 835 0.285884039737991 313 5724242
SGTC_8 0354-0001 70 µM 0.565304827523554 0.240443301939322 no 836 0.285933222852279 314 4993152
SGTC_2250 alverine citrate 130 µM 0.56367152437365 0.241050439681174 no 837 0.28648885010257 300 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1615 st002656 86.5 µM 0.562104004908206 0.241633907097463 no 838 0.287022579929921 305 1584458
SGTC_1841 st054148 70 µM 0.560769054015858 0.242131410965128 no 839 0.287477492712092 332 675442
SGTC_2616 abietic acid 100 µM 0.559045899383759 0.242774409198862 no 840 0.288065197740099 324 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2916 7875993 68.79 µM 0.558217260720053 0.243083945958975 no 841 0.288348017842807 342 1299250
SGTC_1604 st002052 72.4 µM 0.557947488077971 0.243184765167938 no 842 0.288440121351059 297 6254834 YHR062C RPP1
SGTC_1453 4237-0541 195 µM 0.557560614891527 0.243329386543107 no 843 0.288572228539571 299 739892
SGTC_771 0250-0039 27.3 µM 0.556352248196399 0.243781398718462 no 844 0.288985037978492 347 3005115
SGTC_877 0771-0151 33.1 µM 0.556100974041994 0.243875449408319 no 845 0.289070914634579 319 6166523
SGTC_2970 9090938 41.86 µM 0.555792511252444 0.243990932292381 no 846 0.289176352760051 330 17217104
SGTC_2605 digitonin 300 nM 0.555753266974424 0.244005626754686 no 847 0.289189768456059 324 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1434 4073-0095 163 µM 0.554559400018296 0.244452881358208 no 848 0.289598032858256 315 24133745
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.554295075922306 0.24455196394776 no 849 0.289688459837896 354 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_661 1304-0007 33.6 µM 0.553436813984276 0.244873834816618 no 850 0.28998216812235 324 3117130
SGTC_1145 3546-0597 10.2 µM 0.552366495989623 0.245275551532911 no 851 0.290348640220614 313 875334
SGTC_416 estradiol valerate 100 µM 0.55228527155822 0.245306051519769 no 852 0.290376459954111 334 13791 A steroid.
SGTC_122 0236-0016 402.397 µM 0.551825482684013 0.245478741874937 no 853 0.29053396323766 337 6808838
SGTC_776 4476-4378 112 µM 0.549991164182029 0.246168336201416 no 854 0.291162716985186 340 2892008
SGTC_3313 9133968 57.047 µM 0.549552295822441 0.246333478400265 no 855 0.291313243084645 308 1494643
SGTC_172 1112-0046 2.638 µM 0.549440854803446 0.24637542210128 no 856 0.291351471675854 312 2802135 YIL048W NEO1
SGTC_2483 5729050 27.16 µM 0.547922644747774 0.246947220702481 no 857 0.291872509632933 331 2865180
SGTC_2468 5987765 72.9 µM 0.547651028470804 0.24704959351114 no 858 0.291965771991312 313 26772094
SGTC_890 0929-0006 47.2 µM 0.546785283650191 0.247376046211233 no 859 0.292263127312238 312 1378169
SGTC_1102 cgs 12066b 26.1 µM 0.54628574960094 0.247564514000095 no 860 0.292434765154109 315 6438352 A 5-HT1B full agonist.
SGTC_2948 9070189 9.45 µM 0.545150436793383 0.24799313808301 no 861 0.292825028127946 297 6473636 YDL196W YDL196W
SGTC_863 0466-0191 129 µM 0.544777227203654 0.248134125433938 no 862 0.292953371445051 339 765160 YPR165W RHO1
SGTC_943 3253-1379 105 µM 0.543158087719232 0.248746282358739 no 863 0.293510480543302 349 668464
SGTC_2788 5282734 71.43 µM 0.542051474865015 0.249165127703662 no 864 0.293891522923405 341 743706
SGTC_1632 st005650 90 µM 0.541163477831153 0.249501499540923 no 865 0.294197454208157 311 2759605
SGTC_2151 5563267 85.4165 µM 0.540525949339319 0.249743143022173 no 866 0.294417185175389 355 5310824
SGTC_1255 0566-0045 221 µM 0.540111271190396 0.249900385848867 no 867 0.294560149058972 332 2788469
SGTC_2781 5567276 71.43 µM 0.539849487570933 0.249999679274407 no 868 0.294650417719648 333 2853274
SGTC_2828 7998861 71.43 µM 0.538927002459098 0.250349740793842 no 869 0.294968612222209 277 2988188
SGTC_3084 9116877 49.47 µM 0.538102650111751 0.250662782941908 no 870 0.295253091491044 312 27241325
SGTC_573 3702-0553 84.7 µM 0.537175200361304 0.251015223305477 no 871 0.29557329996025 316 1222756
SGTC_302 1094-0063 18.9 µM 0.536849674832736 0.251138988464118 no 872 0.295685727752841 326 5440289
SGTC_678 1218-2179 85.9 µM 0.536035525754626 0.251448670086545 no 873 0.29596699903127 335 6820081 YOR116C RPO31
SGTC_112 phenothiazine 287.218 µM 0.535904516913981 0.251498521364204 no 874 0.296012271284854 349 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2780 5215298 71.43 µM 0.535898842185884 0.2515006808208 no 875 0.296014232352047 342 2834131
SGTC_2568 diosmetin 100 µM 0.534892848244769 0.251883655741211 no 876 0.296361976989182 336 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_418 lividomycin a 100 µM 0.532957834810894 0.252621166548555 no 877 0.297031384338785 319 72394 An antibiotic.
SGTC_1831 st055328 12 µM 0.532408221123126 0.252830853480516 no 878 0.29722164623025 310 1103068
SGTC_1561 5-methoxyflavone 52.9 µM 0.532387336955982 0.252838822950583 no 879 0.297228876881355 326 94525
SGTC_351 caspofungin 25 nM 0.532173304626378 0.25292050604603 no 880 0.29730298516914 324 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1758 st042942 75.2445 µM 0.530644097266688 0.253504515153111 no 881 0.297832715786253 317 669317
SGTC_2357 9067248 200 µM 0.529200556816693 0.254056457224373 no 882 0.298333165233363 342 9150235
SGTC_2798 7813637 45.45 µM 0.52888881836596 0.254175734084905 no 883 0.298441289573284 342 956368
SGTC_228 caffeine 993.056 µM 0.528553891301033 0.254303916053394 no 884 0.29855747659156 309 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1412 3909-8563 178 µM 0.52829444951632 0.254403231879759 no 885 0.298647491720354 351 23767530
SGTC_411 enrofloxacin 100 µM 0.527177143703734 0.254831175218228 no 886 0.299035289662241 338 71188 A bacterial gyrase inhibitor.
SGTC_2340 7987427 183.45 µM 0.52593744590736 0.255306436968809 no 887 0.299465835177359 315 2239331
SGTC_2317 5986382 200 µM 0.524946183016423 0.255686789563446 no 888 0.299810301615773 363 877883
SGTC_623 k072-0108 16.9 µM 0.524679613868553 0.255789123956308 no 889 0.299902965690317 344 5382803
SGTC_1173 0443-0020 122 µM 0.521676268609328 0.256943567029606 no 890 0.300947875284114 334 5331295
SGTC_1297 1068-0111 14.1 µM 0.521238021289041 0.257112249404657 no 891 0.301100485352127 325 767057
SGTC_1782 st039423 80.636 µM 0.52074536145117 0.257301944013644 no 892 0.301272085018021 326 2068169
SGTC_3320 9137005 35.139 µM 0.520675916013362 0.257328689255221 no 893 0.301296277285555 343 4908713
SGTC_354 2783-3500 4.88 µM 0.517549072022818 0.258534413467499 no 894 0.302386461258598 325 6740761
SGTC_1797 st048695 56.8 µM 0.517123547794356 0.258698723287055 no 895 0.302534958282955 349 592262 YIL048W NEO1
SGTC_81 0411-0046 9.971 µM 0.517047581448549 0.258728062241347 no 896 0.302561472024566 325 12925265
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.516543922677791 0.258922623793763 no 897 0.302737285130197 318 688664
SGTC_90 0870-0863 4.608 µM 0.516107715506742 0.259091190178958 no 898 0.30288958974782 363 1738164
SGTC_3209 9113616 49.47 µM 0.515420633538748 0.259356818781675 no 899 0.303129558498304 355 16649353
SGTC_3226 9131256 49.47 µM 0.514970827255851 0.259530791842835 no 900 0.303286702901456 307 17178073
SGTC_2288 7946289 167.31 µM 0.511404117966754 0.260912430122466 no 901 0.304534056004019 352 1246052
SGTC_2383 9036125 200 µM 0.509753773155793 0.261553002893285 no 902 0.305111987576222 325 79580
SGTC_1217 1183-1422 255 µM 0.509252584971739 0.26174769617487 no 903 0.30528759419305 340 2849664
SGTC_3164 9100705 49.47 µM 0.506559340257387 0.262795195060041 no 904 0.306232021735089 334 17174235
SGTC_2804 7954240 19.48 µM 0.506437695787938 0.262842557486382 no 905 0.306274708704061 324 828705
SGTC_2978 9011784 42.97 µM 0.506356701544039 0.262874095117149 no 906 0.306303132324195 339 2994934
SGTC_749 1000-0129 128 µM 0.505664544629789 0.2631436868617 no 907 0.306546081133831 344 708470
SGTC_2792 7535235 81.82 µM 0.50392956773961 0.263820072169235 no 908 0.307155435945648 318 1281891
SGTC_539 4859-0462 2.54 µM 0.503716973036402 0.263903013700003 no 909 0.307230139679292 339 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1448 4255-0083 152 µM 0.503557870917421 0.263965094371051 no 910 0.307286051867561 366 5399660
SGTC_1040 k898-0338 155 µM 0.503415899962001 0.264020496850598 no 911 0.307335947548348 365 20969351
SGTC_1429 4049-0205 9.46 µM 0.502067744926241 0.264546893477902 no 912 0.307809934141469 322 22774478
SGTC_317 4495-0002 170 µM 0.5020675013456 0.264546988633903 no 913 0.307810019808974 333 15991618
SGTC_3178 9107506 49.47 µM 0.501487978949455 0.264773431265793 no 914 0.308013867951134 340 8897194
SGTC_3251 9135047 49.47 µM 0.501473702884277 0.264779010740231 no 915 0.308018890333123 330 17682963
SGTC_2038 4100038 30.985 µM 0.500931958387529 0.264990783385501 no 916 0.308209504973629 326 3596803
SGTC_3148 9097893 49.47 µM 0.500455473330817 0.265177116655953 no 917 0.30837720062261 288 17174100
SGTC_719 2810-4230 27.3 µM 0.499833316619579 0.265420516103291 no 918 0.308596224609966 340 721079
SGTC_1876 myriocin 605 nM 0.499570458328584 0.265523385284201 no 919 0.30868878169095 373 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_3312 9133330 71.43 µM 0.499267009370455 0.265642164705098 no 920 0.308795646583154 352 17617324
SGTC_1776 st049249 45.9 µM 0.499176335416396 0.265677662557007 no 921 0.308827582154491 320 1822314
SGTC_1748 st037455 53.6035 µM 0.496509647413648 0.26672271587879 no 922 0.309767441239887 349 580690
SGTC_3295 9122362 53.5725 µM 0.496227950698989 0.266833231743456 no 923 0.309866796457413 353 4730473
SGTC_687 k029-0044 34.9 µM 0.496081419711162 0.26689072824451 no 924 0.309918483837736 343 5829338
SGTC_1904 st060225 78 µM 0.495319780076043 0.267189684679203 no 925 0.310187205311649 319 66595
SGTC_3064 1327-0027 10 µM 0.493180971586277 0.268030105951307 no 926 0.310942360879548 337 16000455 YPR107C YTH1
SGTC_2025 5147754 141 µM 0.493147716316706 0.268043183743339 no 927 0.310954108716912 330 315777 YLR208W SEC13
SGTC_1316 1272-0050 65.9 µM 0.491318232325839 0.268763131549233 no 928 0.311600693249908 338 7340392
SGTC_3108 9121785 49.47 µM 0.491180459620805 0.268817387865187 no 929 0.311649409067238 350 17140271
SGTC_662 k832-1615 104 µM 0.490188457827015 0.26920821075851 no 930 0.312000273785876 365 5878478
SGTC_84 0443-0269 128.823 µM 0.490117585184725 0.269236143640773 no 931 0.312025347523038 333 6150058
SGTC_220 paclitaxel 373.376 µM 0.490070280965152 0.269254788360165 no 932 0.312042083570693 349 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1350 1495-0454 146 µM 0.48641434796762 0.27069771206784 no 933 0.31333670988164 354 1069057
SGTC_1903 st060211 78.3 µM 0.486276533351785 0.270752180167912 no 934 0.313385557466672 325 688960
SGTC_186 3455-3465 67.277 µM 0.484842574654866 0.27131924426061 no 935 0.313894009854806 354 755278
SGTC_1114 scopoletin 1.73284 µM 0.48406416594583 0.2716273164356 no 936 0.314170165774509 358 5280460 A coumarin with genotoxic properties.
SGTC_852 0418-0143 439 µM 0.483929565945402 0.27168060496954 no 937 0.314217928350485 335 5369229
SGTC_1464 k208-0027 110 µM 0.482688922379745 0.272172024308028 no 938 0.314658314975112 367 X1464
SGTC_2849 9019321 12.99 µM 0.482147168667838 0.27238675164142 no 939 0.314850702051258 343 16489627
SGTC_1880 MG-132 525 µM 0.481777322160994 0.272533390839138 no 940 0.314982070469985 359 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1512 0259-0544 12.2 µM 0.481118698432841 0.272794623355222 no 941 0.315216069684145 345 18476
SGTC_2044 5102272 200 µM 0.479896182583421 0.27327984365933 no 942 0.315650607904459 332 592666
SGTC_965 1291-5240 308 µM 0.479172335923621 0.273567341985969 no 943 0.315908016444108 356 2834598
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.478920939065505 0.273667227114651 no 944 0.315997437074704 341 1241132 A phosphatase inhibitor.
SGTC_1980 st071811 45.7 µM 0.478301355051384 0.273913477557676 no 945 0.31621786603056 360 4974850
SGTC_2330 7979373 200 µM 0.477520187131313 0.274224104714194 no 946 0.316495874680427 319 1863007
SGTC_2361 9034121 116 µM 0.475923471634645 0.274859570627591 no 947 0.317064449843339 364 6496917
SGTC_3052 9092717 49.47 µM 0.475493867727394 0.275030669582801 no 948 0.317217501536769 349 25237534
SGTC_1989 st071868 50.2 µM 0.474623538087789 0.275377457729729 no 949 0.317527663025346 365 16414057
SGTC_1718 roemerine 11.9335 µM 0.474486126593853 0.275432229837368 no 950 0.31757664441148 320 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1940 st075990 51.1 µM 0.474261636461348 0.275521722947062 no 951 0.317656672519919 338 1084979
SGTC_586 0957-0265 8.15 µM 0.471348981202606 0.276684149321785 no 952 0.318695771411843 360 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2571 chrysanthemic acid 100 µM 0.471277516743774 0.276712700613383 no 953 0.318721284552113 367 2743 An insecticide.
SGTC_1754 st042065 16.137 µM 0.471167558881922 0.27675663350669 no 954 0.318760541692355 342 1126236 YIL048W NEO1
SGTC_941 3237-0776 460 µM 0.470615181579754 0.276977383673746 no 955 0.318957782123418 360 760008
SGTC_132 0417-1715 25.805 µM 0.469689875150992 0.277347362986093 no 956 0.319288301305117 362 6769098
SGTC_2910 7948405 25.97 µM 0.467467305887938 0.278237032700001 no 957 0.320082788993497 361 2971328
SGTC_3277 9138724 49.47 µM 0.465550138151638 0.279005569721925 no 958 0.320768770309845 348 15943418
SGTC_1820 st053765 18.6 µM 0.465207127924471 0.279143181398437 no 959 0.320891567371857 342 3690829
SGTC_2663 amphotericin b 100 µM 0.464601139515579 0.279386377445592 no 960 0.321108558048247 350 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1531 st059297 52.4 µM 0.462006804642795 0.280428701223709 no 961 0.322038220358506 345 7566702
SGTC_2324 6149169 200 µM 0.461670285114565 0.280564042209075 no 962 0.322158891646786 371 2888231
SGTC_2650 prasterone 100 µM 0.460148097136586 0.281176628324077 no 963 0.322704961436485 336 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2848 9016370 25.97 µM 0.460072624986779 0.281207017976214 no 964 0.322732046283097 341 7894410
SGTC_684 1140-0066 328 µM 0.459747731931476 0.281337857676969 no 965 0.322848652063203 339 6813534
SGTC_2941 9056145 11.23 µM 0.459697504646246 0.281358087641258 no 966 0.322866680447717 368 2119517
SGTC_1698 5-fluorocytosine 1.055 µM 0.45954492583605 0.281419545873033 no 967 0.322921449039446 353 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3089 9117425 49.47 µM 0.459159951213734 0.281574641143134 no 968 0.323059653826121 375 9401657
SGTC_2824 7998404 51.95 µM 0.458126547299443 0.281991173782522 no 969 0.323430763642652 369 837851
SGTC_1423 4048-0112 5.59 µM 0.457277787883548 0.282333503853762 no 970 0.323735696489656 358 X1423
SGTC_1342 1486-1464 234 µM 0.456515448048685 0.28264114866018 no 971 0.324009682383203 354 3253938
SGTC_2474 5321570 43.32 µM 0.454162040878848 0.283591889132191 no 972 0.324856100964658 380 2841384
SGTC_3100 9120536 49.47 µM 0.452846871327046 0.28412386404081 no 973 0.325329504960004 357 16421196
SGTC_851 0394-0702 453 µM 0.451239342202749 0.28477474337819 no 974 0.325908528694899 369 762646
SGTC_2750 bromebric acid 70.15 µM 0.450308414003195 0.285151995940874 no 975 0.326244036441506 353 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1439 4092-1168 46 µM 0.449941331819533 0.285300819047148 no 976 0.326376372028014 366 2886240
SGTC_99 0109-0120 622.8 µM 0.449770377162646 0.285370140411949 no 977 0.326438009788513 372 759414
SGTC_1837 st055472 66.5 µM 0.449470418608925 0.285491791674666 no 978 0.326546171401327 339 676091
SGTC_1875 nocodazole 6 µM 0.449352017134839 0.285539817399886 no 979 0.326588869629192 347 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2107 5363541 170.161 µM 0.449155118458399 0.285619691488118 no 980 0.32665988073929 361 244052
SGTC_563 tetrahydrosecaminediol 614 µM 0.448366591111257 0.285939672682887 no 981 0.326944324450398 356 334274 A psychoactive constituent of the cannabis plant.
SGTC_2157 5649910 96.377 µM 0.447679256102678 0.2862187293686 no 982 0.327192347328976 349 2858091
SGTC_387 norethindrone acetate 66.7 µM 0.446836095160446 0.28656122762279 no 983 0.32749670379033 373 541197
SGTC_553 k007-0256 45.7 µM 0.44606544557131 0.28687444117883 no 984 0.32777498609511 348 6287000
SGTC_2886 9058944 51.95 µM 0.443910284586018 0.287751219018202 no 985 0.328553724292738 345 4949929
SGTC_1406 3909-7906 11.9 µM 0.443355574309837 0.287977094873747 no 986 0.328754282059946 373 X1406
SGTC_878 0828-0289 13.7 µM 0.442276809788078 0.288416603083631 no 987 0.329144454986318 356 745350 YLR208W SEC13
SGTC_2518 prenyletin 46.28 µM 0.441969942375757 0.288541684167117 no 988 0.329255478353733 333 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2394 5221648 200 µM 0.44147800506508 0.28874225421549 no 989 0.329433490665521 372 788586
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.441070512406522 0.288908444636664 no 990 0.329580975137014 358 97141
SGTC_2048 5246248 200 µM 0.440478590326201 0.289149932278204 no 991 0.329795257662661 335 677046
SGTC_1818 st052136 56.3 µM 0.439822302606668 0.289417790198365 no 992 0.330032906600638 357 674169
SGTC_195 4234-0266 16.654 µM 0.438232979296895 0.290066940672938 no 993 0.330608701983998 365 2303354
SGTC_2875 9039966 71.43 µM 0.436803036376914 0.290651575680822 no 994 0.331127098384053 386 6463691
SGTC_155 k072-0202 43.6 µM 0.435822800999854 0.291052665029615 no 995 0.331482649731605 387 5857737
SGTC_3156 9099931 49.47 µM 0.433599671715393 0.291963274263826 no 996 0.332289586604021 356 18111053
SGTC_1712 st032288 53.4 µM 0.43290275861763 0.292249007599811 no 997 0.33254270791535 355 2883011
SGTC_2592 piperlongumine 83.33 µM 0.432761904223795 0.292306773490924 no 998 0.332593876012819 370 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2926 9010726 65.15 µM 0.432422280447183 0.292446078662773 no 999 0.332717263779279 354 2994293
SGTC_390 dec-rvkr-cmk 16.7 µM 0.432162484382632 0.292552661334163 no 1000 0.332811661796479 351 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_49 0717-0965 32.132 µM 0.431448777450136 0.292845556141264 no 1001 0.33307104481816 380 5889349 YGL099W LSG1
SGTC_1245 0418-0076 17.2 µM 0.430834304194424 0.293097835907125 no 1002 0.33329442727285 389 6790114
SGTC_246 cycloheximide 667 µM 0.430632574422003 0.293180680588965 no 1003 0.333367775978561 368 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2486 5283202 22.39 µM 0.430133632441405 0.293385628495603 no 1004 0.333549218055624 361 1377751
SGTC_2539 epi(13)torulosol 80 µM 0.429886980074373 0.293486969170118 no 1005 0.333638928478318 344 6708597
SGTC_2397 5161689 200 µM 0.42932171713264 0.293719276717357 no 1006 0.333844557260359 359 2259942
SGTC_2576 guaiol 23.12 µM 0.429076959079517 0.293819891950612 no 1007 0.33393360971848 348 227829
SGTC_585 0kpi-0023 191 µM 0.427754348256573 0.294363866986373 no 1008 0.334414988467099 362 64601
SGTC_136 0097-0015 404.482 µM 0.427120782366036 0.294624610176573 no 1009 0.334645678283418 344 4861337
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.427103943015814 0.29463154184184 no 1010 0.334651810568215 353 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1306 1185-0270 9.02 µM 0.426803589648008 0.294755190424173 no 1011 0.334761195853658 384 1548076
SGTC_71 0417-1750 47.813 µM 0.426536256010855 0.294865265663775 no 1012 0.334858567523912 325 6811472
SGTC_492 tmb-8 126 µM 0.424360192475201 0.29576196878644 no 1013 0.335651573704368 379 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2139 5578692 56.4705 µM 0.423672571643045 0.296045580971419 no 1014 0.335902310577354 357 650991 YMR113W FOL3
SGTC_1141 3253-0389 52.6 µM 0.422873287684553 0.296375405883103 no 1015 0.336193856558589 389 5402031
SGTC_43 0570-0105 72.5 µM 0.42274922379169 0.296426616008098 no 1016 0.33623911881463 362 1114046 YDL195W SEC31
SGTC_2181 6316240 54.2555 µM 0.419761713927715 0.297660999764519 no 1017 0.337329768210521 368 12779990
SGTC_2094 5332512 191.667 µM 0.419316095260914 0.297845321999776 no 1018 0.337492567582 377 755774
SGTC_283 0987-0079 11.7 µM 0.418117647206636 0.298341296758565 no 1019 0.337930551511458 382 411556
SGTC_2166 5933061 31.504 µM 0.417798516404219 0.29847343160915 no 1020 0.338047217848667 365 2877375
SGTC_2382 9035899 200 µM 0.417493852113696 0.298599601495703 no 1021 0.3381586101013 385 6462679
SGTC_442 cape 100 µM 0.41719482548984 0.298723460250045 no 1022 0.338267954872357 377 5281787
SGTC_1421 4029-0249 71.4 µM 0.416567523028061 0.298983368827815 no 1023 0.338497384262978 376 2894095
SGTC_3219 9131112 49.47 µM 0.414851731840419 0.299694792130029 no 1024 0.339125223226002 350 17612988 YMR079W SEC14
SGTC_3044 9093193 49.47 µM 0.414454231128784 0.29985971830042 no 1025 0.339270739748695 383 25236277
SGTC_57 miconazole 162.5 nM 0.413872912678324 0.300100985847456 no 1026 0.339483591184354 372 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3284 9108171 64.8615 µM 0.412710019159582 0.30058389075157 no 1027 0.339909541663381 383 8687505
SGTC_2611 pyromycin 23.93 µM 0.412631119419553 0.300616667481729 no 1028 0.339938448869193 341 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2748 diazoxide 86.69 µM 0.412029794238636 0.300866524504806 no 1029 0.34015879268071 366 3019 A potassium channel activatior.
SGTC_1746 st038117 42 µM 0.404089172458348 0.304174682562849 no 1030 0.343073573388584 367 2898218
SGTC_2187 6125751 200 µM 0.403415408847981 0.304456124981559 no 1031 0.3433213265213 368 874498
SGTC_2618 avocadyne 43.43 µM 0.402830671523398 0.304700473512881 no 1032 0.343536397926605 382 3015189
SGTC_1760 st045453 10.4495 µM 0.400708813803429 0.305587881297429 no 1033 0.344317260454231 409 3323419 YIL048W NEO1
SGTC_2858 9025781 8.96 µM 0.400549510161149 0.305654551800161 no 1034 0.34437591245476 371 4894980 YPL153C RAD53
SGTC_2061 5245884 80.95 µM 0.399371627301555 0.306147709873496 no 1035 0.344809698361158 395 573863
SGTC_838 0109-0203 71.4 µM 0.398067631430054 0.306694079153935 no 1036 0.345290166689484 354 759422
SGTC_922 1866-0035 480 µM 0.397284670877644 0.307022343233693 no 1037 0.345578775045444 381 3156169
SGTC_2490 carminic acid 95.39 µM 0.397116052967241 0.307093058248047 no 1038 0.345640941321811 364 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1859 st055998 20 µM 0.395634363182079 0.307714757945141 no 1039 0.346187391533273 369 676301
SGTC_2896 9052656 71.43 µM 0.395556206435262 0.307747566958181 no 1040 0.346216224806385 376 6469436
SGTC_3065 9113888 49.47 µM 0.394685428118668 0.308113210380987 no 1041 0.34653752910296 383 16648368
SGTC_786 4544-0069 423 µM 0.393983454172625 0.308408110881131 no 1042 0.346796627503175 359 748821 YLR208W SEC13
SGTC_876 0720-0963 56.8 µM 0.393632731786572 0.308555496318656 no 1043 0.34692610589944 396 765861
SGTC_1861 st057647 17.4 µM 0.393242652941515 0.308719456913776 no 1044 0.347070134765473 416 688668
SGTC_1312 1218-2183 165 µM 0.39246073268683 0.309048233777476 no 1045 0.347358909805914 365 6744073
SGTC_629 3448-6466 76.7 µM 0.391405182670527 0.309492307433992 no 1046 0.347748881032482 393 573744
SGTC_2074 5212007 75.395 µM 0.38871237713569 0.310626439863048 no 1047 0.348744462706743 402 758611
SGTC_3200 9114385 49.47 µM 0.388201770568694 0.310841696283218 no 1048 0.348933361497789 342 17018030 YLR208W SEC13
SGTC_188 3229-0966 278.469 µM 0.387837130396484 0.310995457284317 no 1049 0.349068282974184 381 5722370
SGTC_2442 5158906 48.48 µM 0.387217304165815 0.311256900530163 no 1050 0.349297670298366 381 1893835
SGTC_3030 9087619 49.47 µM 0.385909988594357 0.311808639551134 no 1051 0.349781666380311 375 25236973
SGTC_850 0388-0143 75.9 µM 0.385631341903223 0.311926294189766 no 1052 0.349884858924094 371 67273
SGTC_1792 st045773 43.6 µM 0.385535095694556 0.311966937255234 no 1053 0.349920504813608 361 2919270
SGTC_1575 cyproterone acetate 48 µM 0.385440145915011 0.312007035105098 no 1054 0.349955671851805 399 9880 An androgen receptor antagonist and liver toxin.
SGTC_1618 st003135 44.5 µM 0.383392133799177 0.312872464258869 no 1055 0.35071451745522 412 1270615
SGTC_466 geldanamycin 89.2 µM 0.38287078526492 0.31309293571326 no 1056 0.350907786916826 379 5288382 HSP90 inhibitor.
SGTC_2240 6690706 185.951 µM 0.382400034033386 0.313292067662769 no 1057 0.351082332567207 349 805876
SGTC_3103 9120822 49.47 µM 0.382290668434513 0.313338338078262 no 1058 0.351122887761582 407 17141819
SGTC_3199 9111318 49.47 µM 0.381165192068958 0.313814675404951 no 1059 0.351540337844974 385 8548020
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.380623864148917 0.314043893201605 no 1060 0.351741185436166 383 5377381
SGTC_2874 9043904 71.43 µM 0.380153322869594 0.314243195680532 no 1061 0.351915802855943 383 4463428
SGTC_2841 9004761 38.96 µM 0.379434055804549 0.314547953140974 no 1062 0.352182782536691 344 2991039
SGTC_3293 9120939 62.045 µM 0.37825151947946 0.31504927504596 no 1063 0.352621878211241 401 934087
SGTC_1472 k841-0093 193 µM 0.377865862583527 0.315212843360049 no 1064 0.352765121625116 388 X1472
SGTC_3271 9137798 49.47 µM 0.377399801264415 0.31541056188008 no 1065 0.35293825727536 373 6498326
SGTC_3141 9094609 49.47 µM 0.377189028261384 0.31549999607554 no 1066 0.353016566676925 402 25236309 YDL196W YDL196W
SGTC_2686 alizarin 95.37 µM 0.376293346983265 0.315880167791648 no 1067 0.353349412407202 343 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1534 6-azauridine 81.6 µM 0.375899672803095 0.316047324371019 no 1068 0.353495741885839 373 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_990 3985-0011 41.3 µM 0.375768137872935 0.316103183329933 no 1069 0.35354463850953 410 5399565 YGL099W LSG1
SGTC_898 1000-0849 28.3 µM 0.375251410665145 0.316322662581608 no 1070 0.353736749398629 407 6751807
SGTC_497 capsazepine 133 µM 0.374159433875175 0.316786691221481 no 1071 0.354142851353651 355 2733484 A calcium channel blocker.
SGTC_3019 9081971 49.47 µM 0.37341264292772 0.317104201432982 no 1072 0.354420675608052 389 16451803
SGTC_3353 9151644 39.2805 µM 0.373351702641997 0.317130117125305 no 1073 0.35444335028628 418 4909158
SGTC_1509 1326-1131 80 µM 0.372247870080835 0.31759969221365 no 1074 0.35485415384152 374 768313
SGTC_3017 9080681 49.47 µM 0.371651639734248 0.317853453329834 no 1075 0.35507611784537 410 16451914
SGTC_2724 maprotiline 69.64 µM 0.371294482952282 0.31800550352804 no 1076 0.355209103358055 398 4011 A tricyclic antidepressant.
SGTC_1765 st044815 90.4 µM 0.369455143131485 0.318789039995364 no 1077 0.355894251162073 380 645695
SGTC_2260 7964312 200 µM 0.369406228709464 0.318809888027844 no 1078 0.355912477983841 373 231951
SGTC_1375 2910-0797 186 µM 0.368654301488096 0.319130442382936 no 1079 0.356192707597904 407 742508
SGTC_2819 7996655 46.38 µM 0.367744292919834 0.319518569387445 no 1080 0.356531955152653 416 6456960
SGTC_1672 st016598 6.51 µM 0.367430263620919 0.319652551691336 no 1081 0.356649050384353 405 4665860 YNL267W PIK1
SGTC_1504 k297-0033 30 µM 0.367364169328555 0.319680754178983 no 1082 0.356673697342815 359 4388117
SGTC_146 3448-8650 53.125 µM 0.36708992212742 0.319797786817716 no 1083 0.356775972163045 419 2891488 YIL048W NEO1
SGTC_1206 3978-0017 132 µM 0.366843512310414 0.31990295539484 no 1084 0.356867874389082 403 3873677
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.364784477190948 0.320782324083885 no 1085 0.357636146620132 408 551469
SGTC_1445 4239-0156 97.7 µM 0.364542819601222 0.320885596825931 no 1086 0.357726352398088 418 4008346
SGTC_1667 st014849 34.6 µM 0.364227703323873 0.321020283070745 no 1087 0.357843990721176 375 5348460
SGTC_218 alverine citrate 93.75 µM 0.364170267038208 0.321044834888629 no 1088 0.35786543412908 408 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2762 leflunomide 42.06 µM 0.363690655755528 0.321249880924683 no 1089 0.358044510920498 385 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2697 mebhydrolin 72.4 µM 0.363016491618062 0.321538195397035 no 1090 0.358296282475668 380 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_3119 9125183 49.47 µM 0.360745862097725 0.322510047872438 no 1091 0.359144718497881 381 22695334
SGTC_3252 9135871 49.47 µM 0.359907253022738 0.322869288423722 no 1092 0.359458246439328 399 17682838
SGTC_1715 st032160 10.2275 µM 0.359730761775346 0.322944914225418 no 1093 0.359524242687328 404 5289825
SGTC_2521 angolensin 13.4 µM 0.359314680970487 0.323123232175564 no 1094 0.359679846427845 386 821428 A flavenoid.
SGTC_1115 galangin 695.678 nM 0.359276178065353 0.323139735254693 no 1095 0.359694246720943 424 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1170 0310-0127 64.8 µM 0.357113545139005 0.324067239036163 no 1096 0.360503402311599 421 774975
SGTC_96 0929-0093 37.281 µM 0.355540273537929 0.324742666519836 no 1097 0.361092439603832 368 6991579
SGTC_158 k038-0087 26.446 µM 0.355401308161185 0.324802354047035 no 1098 0.361144484489827 376 X158
SGTC_1465 k213-0056 144 µM 0.355134520780006 0.324916955477711 no 1099 0.361244408083899 362 24048857 YMR208W ERG12
SGTC_324 1315-0088 19.6 µM 0.354898674538284 0.325018279603941 no 1100 0.361332750746583 421 6787421
SGTC_1143 3454-2408 5.08 µM 0.354297345451482 0.325276680816479 no 1101 0.36155802846144 389 X1143
SGTC_58 0957-0393 9 µM 0.354025248386488 0.325393633120026 no 1102 0.361659980777178 371 6997992
SGTC_404 fumagillin 50 µM 0.353672156824284 0.325545423977949 no 1103 0.361792295641293 376 12015870 A methionine aminopeptidase binder.
SGTC_1735 st034310 56.75 µM 0.353057360755846 0.325809788271602 no 1104 0.362022719100569 436 871153
SGTC_1830 st055982 50.3 µM 0.352938303621779 0.325860993353332 no 1105 0.362067347089988 423 455313 An antimicrobial agent.
SGTC_560 2332-1943 155 µM 0.352069473291252 0.326234766524085 no 1106 0.362393080668352 380 21177716
SGTC_3056 9094900 49.47 µM 0.351280186690605 0.326574471141535 no 1107 0.362689078861876 375 25236784
SGTC_591 4299-0174 154 µM 0.350836735945853 0.326765393042416 no 1108 0.362855417745208 415 5509088
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.350349218571096 0.326975339607865 no 1109 0.363038315937285 387 17037758
SGTC_2371 9071574 200 µM 0.349084369835529 0.327520294754756 no 1110 0.363512985216664 413 45596039
SGTC_1034 k072-0165 12.7 µM 0.348462880483224 0.327788195815704 no 1111 0.363746293039667 411 5835461
SGTC_2160 5660466 132.927 µM 0.348030362283452 0.327974690736319 no 1112 0.363908690698436 407 2859134
SGTC_2033 5192550 145 µM 0.347771972142068 0.328086124900607 no 1113 0.364005720141765 366 182073
SGTC_6 0844-0013 19.835 µM 0.347090969980809 0.328379889379081 no 1114 0.364261488610453 404 1584900
SGTC_3263 9137018 49.47 µM 0.344801383307309 0.329368327753874 no 1115 0.36512184652664 423 43844957
SGTC_1717 st033143 58.0435 µM 0.344419273418435 0.329533404975758 no 1116 0.36526549821759 429 674616
SGTC_2167 5876490 200 µM 0.343437962403818 0.329957498260302 no 1117 0.365634502198358 405 686534
SGTC_2612 dictamnine 15.46 µM 0.340874243453103 0.331066491596326 no 1118 0.366599127776419 410 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1855 st056195 39.6 µM 0.34014432426013 0.331382506062672 no 1119 0.366873921850169 386 4028379
SGTC_1189 1431-2119 7.28 µM 0.338475034722025 0.332105666806855 no 1120 0.367502618724266 404 3107275
SGTC_2211 7117706 200 µM 0.33660363494045 0.332917128634323 no 1121 0.368207857837026 405 822771
SGTC_487 nimodipine 119 µM 0.336394720586672 0.333007765113068 no 1122 0.36828661506004 425 4497 L-type voltage-gated calcium channels inhibitor
SGTC_34 0469-0683 81.75 µM 0.333913858617416 0.334084819622423 no 1123 0.369222280884198 391 3690923
SGTC_1815 st051655 58.2 µM 0.332371650769338 0.334755051968644 no 1124 0.369804321171475 393 5984156
SGTC_393 acivicin 6.25 µM 0.33216804658293 0.334843576280664 no 1125 0.369881185176012 395 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1146 3579-1023 7 µM 0.331211142238169 0.335259748052635 no 1126 0.370242502242202 399 X1146
SGTC_721 1187-1332 279 µM 0.331207844431547 0.335261182667275 no 1127 0.370243747657678 403 25730
SGTC_637 1181-0519 7.26 µM 0.331087917820746 0.335313354875699 no 1128 0.370289038822921 422 6252091 YGR060W ERG25
SGTC_109 0132-0036 33.701 µM 0.330086723285498 0.335749032871183 no 1129 0.370667217412284 427 67274 A color developer.
SGTC_968 1309-0633 340 µM 0.329702460999848 0.335916306433145 no 1130 0.370812397012091 410 3761976
SGTC_180 1486-1293 102.781 µM 0.328664806609557 0.33636817103649 no 1131 0.371204529022898 391 4140536
SGTC_269 exalamide 29 µM 0.3273980778722 0.33692011053329 no 1132 0.371683410032618 387 3316 A derivative of salicylamide.
SGTC_2405 ticlatone 3.52 µM 0.32693045911361 0.337123950399612 no 1133 0.371860241404089 336 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_349 k015-0014 24 µM 0.326675956299585 0.337234910919498 no 1134 0.371956493734901 388 2196908
SGTC_3298 9116858 71.43 µM 0.325619462739359 0.337695682175959 no 1135 0.372356142471451 426 2506942
SGTC_508 roscovitine 141 µM 0.325068391726139 0.337936118827259 no 1136 0.372564655348853 417 160355 A CDKinase inhibitor.
SGTC_2343 7990716 14.84 µM 0.324850393717226 0.338031251348189 no 1137 0.372647151207255 399 6456862
SGTC_2254 7938975 95.19 µM 0.324444471735062 0.338208419891413 no 1138 0.372800777727221 397 2969277
SGTC_1278 0874-0585 172 µM 0.323717964452361 0.338525600400007 no 1139 0.373075784475477 394 766306
SGTC_31 0508-1974 57.237 µM 0.323088616895684 0.33880045528502 no 1140 0.373314065384155 392 6810525
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.322767095462019 0.338940906447647 no 1141 0.373435817175108 413 279621
SGTC_916 4466-0038 42 nM 0.321714390005298 0.33940091948522 no 1142 0.373834537659916 421 5722064 YGL116W CDC20
SGTC_2280 7785178 200 µM 0.321501750450142 0.339493868169836 no 1143 0.373915092975024 387 2954328
SGTC_614 0462-0418 107 µM 0.320388295719683 0.33998073915655 no 1144 0.37433699849271 407 5188303
SGTC_294 k038-0071 157 µM 0.320310732228822 0.340014664648498 no 1145 0.374366394133736 403 24152826
SGTC_994 3910-0338 138 µM 0.319886731167503 0.340200141345606 no 1146 0.374527098399839 410 3479481
SGTC_3272 9137413 49.47 µM 0.319859294071366 0.340212144869865 no 1147 0.374537498319342 402 17614870
SGTC_2266 7929956 200 µM 0.319212469193807 0.340495172797392 no 1148 0.374782701077058 393 2967153
SGTC_3249 9135183 49.47 µM 0.319145078459576 0.340524665795029 no 1149 0.374808250927318 395 4902779
SGTC_750 4073-0104 132 µM 0.318582916606066 0.340770729265559 no 1150 0.375021404762196 417 22330957
SGTC_2435 5706476 10.6 µM 0.316779408801518 0.341560598405772 no 1151 0.375705494778781 395 5725375
SGTC_923 1900-2434 73.3 µM 0.314829360455629 0.342415428136432 no 1152 0.376445609026796 446 5910570
SGTC_1461 k072-0203 53.8 µM 0.312538501559422 0.343420688639523 no 1153 0.377315653697035 414 5418714
SGTC_2075 5212009 200 µM 0.31182079780872 0.343735855365016 no 1154 0.377588358597814 445 780898
SGTC_353 1988-1175 58.3 µM 0.310169326792084 0.344461481530308 no 1155 0.378216097359104 411 2788357
SGTC_2411 st077133 39.94 µM 0.309631719608595 0.344697820010065 no 1156 0.378420516079262 437 1403142 YNL221C POP1
SGTC_1929 genistein trimethyl ether 50.5 µM 0.309036858766992 0.344959398527572 no 1157 0.378646744477531 436 136420
SGTC_2402 5553605 200 µM 0.307755833982816 0.345522955848502 no 1158 0.37913406540804 398 6758546
SGTC_2902 5787006 60.46 µM 0.306279697519757 0.346172772839428 no 1159 0.379695847976321 396 591003
SGTC_652 0437-0092 114 µM 0.305928162620195 0.346327590556242 no 1160 0.379829671326495 397 3091274
SGTC_3346 9158254 43.5805 µM 0.305326457428104 0.346592644097339 no 1161 0.38005876363999 407 17639500
SGTC_1327 1436-0082 2.18 µM 0.30384570573139 0.347245240806717 no 1162 0.380622721867677 413 15992205
SGTC_882 0843-0131 351 µM 0.302371358730447 0.347895465133428 no 1163 0.381184492957206 408 5425421
SGTC_879 0831-1030 162 µM 0.302362766934929 0.347899255646104 no 1164 0.38118776742806 394 1549252
SGTC_14 0354-0009 295 µM 0.301829882523242 0.348134382313574 no 1165 0.381390874827081 440 1713507
SGTC_1398 3558-0053 112 µM 0.301649898414539 0.348213810599772 no 1166 0.381459482648757 418 4532369
SGTC_572 0960-0087 17.7 µM 0.301467431893259 0.348294341189148 no 1167 0.381529040539238 428 6796365
SGTC_2155 5570423 76 µM 0.301385631512846 0.348330445555053 no 1168 0.381560224827408 420 797402
SGTC_2495 cafestol 54.53 µM 0.300160930943306 0.348871157783426 no 1169 0.382027202192002 418 16667697 An anti-infammatory.
SGTC_2730 imipramine 71.33 µM 0.297856183166853 0.349889548915553 no 1170 0.382906465785503 378 3696 A tricyclic antidepressant.
SGTC_3111 9122088 49.47 µM 0.297835913378641 0.349898510263601 no 1171 0.382914201414853 424 16876704
SGTC_2662 daunorubicin 22.37 µM 0.296965957590395 0.350283199663958 no 1172 0.383246249625805 395 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1488 4013-0813 75.9 µM 0.296429962485918 0.350520290110972 no 1173 0.383450873113229 411 2910057
SGTC_1853 st056710 91.2 µM 0.295557165126458 0.350906485252898 no 1174 0.383784145039474 429 269167
SGTC_491 tetrandrine 80.3 µM 0.295209456215891 0.351060382338987 no 1175 0.383916939361186 427 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_862 0452-0056 10.2 µM 0.295178657366811 0.351074015187248 no 1176 0.383928702478946 400 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1906 st060206 94.7 µM 0.295124038749939 0.351098192124228 no 1177 0.383949563431247 438 5133468
SGTC_674 0498-0004 451 µM 0.2943875054109 0.351424277520345 no 1178 0.384230906684392 403 4231473
SGTC_3314 9135860 59.4275 µM 0.294009590847896 0.351591634106374 no 1179 0.384375287334401 433 25252478
SGTC_701 4424-0219 185 µM 0.29352711458235 0.351805336852702 no 1180 0.384559638650612 405 2911779
SGTC_615 k087-0205 167 µM 0.292462016035045 0.352277265640811 no 1181 0.384966698865439 427 9642773
SGTC_658 3253-0951 102 µM 0.291985935339311 0.352488283309233 no 1182 0.385148688803632 435 1184878
SGTC_313 3474-0040 5.03 µM 0.291395365478994 0.352750110169045 no 1183 0.385374479324682 423 1043375 YIL048W NEO1
SGTC_3045 9092950 49.47 µM 0.291317253343736 0.352784746107941 no 1184 0.385404346577085 408 44120432
SGTC_2756 carbadox 75.1 µM 0.290034466898959 0.353353724707841 no 1185 0.385894934775958 393 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2036 5160441 105 µM 0.286604334242334 0.354876764195349 no 1186 0.38720764767978 423 134534 YIL048W NEO1
SGTC_117 lucigenin 22.078 µM 0.286114523966984 0.355094438650005 no 1187 0.387395203914558 424 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_320 4092-0846 5.34 µM 0.285330472938557 0.355442973787971 no 1188 0.387695484365885 412 1359356
SGTC_1264 0783-0040 158 µM 0.284353121109168 0.355877606464449 no 1189 0.388069890341408 428 2855798
SGTC_1852 st056254 31.4 µM 0.284037245454971 0.356018117860202 no 1190 0.388190918913249 434 442583
SGTC_1648 st011736 69.8 µM 0.28054568963672 0.357572570439685 no 1191 0.389529438467655 416 2855514
SGTC_1969 st069479 40.1 µM 0.279666972828998 0.35796415178323 no 1192 0.389866509716533 451 3895485
SGTC_514 4466-0038 2.65 nM 0.279304645219284 0.35812565888287 no 1193 0.390005520860842 400 5722064
SGTC_3299 9121982 43.1275 µM 0.278008570689244 0.35870359024207 no 1194 0.390502889774958 409 17594604 YPL160W CDC60
SGTC_1220 1838-0075 193 µM 0.277588893406969 0.358890797576683 no 1195 0.390663979487838 421 5529645
SGTC_1974 st069448 26.9 µM 0.277312453290996 0.359014128985382 no 1196 0.390770099033143 420 6323587 YNR016C ACC1
SGTC_1133 3473-0247 50 µM 0.277161930919494 0.359081289443038 no 1197 0.390827884826545 395 711311
SGTC_3276 9139060 49.47 µM 0.27497185569157 0.360058954568023 no 1198 0.391668930519554 450 4870619
SGTC_2485 5633444 17.78 µM 0.27446223021724 0.360286586618342 no 1199 0.391864712720524 401 5724239
SGTC_1628 st004252 77.7 µM 0.274128811589979 0.3604355399842 no 1200 0.391992816573392 398 692968
SGTC_189 3970-0742 2.116 µM 0.273787425102708 0.360588074906764 no 1201 0.392123993915761 444 2891807
SGTC_2857 9024691 58.44 µM 0.273647717274831 0.360650504170789 no 1202 0.392177680015076 443 16478292
SGTC_983 1491-0821 12.2 µM 0.273586609709523 0.360677811613141 no 1203 0.392201162714788 397 46495113
SGTC_988 1497-1057 103 µM 0.273491779988236 0.360720190050093 no 1204 0.392237605098928 446 3533044
SGTC_1525 8-methoxypsoralen 92.5 µM 0.271429231981001 0.361642344111672 no 1205 0.393030460874525 460 4114 Related to psoralen; DNA damaging agent.
SGTC_2938 9059746 27.26 µM 0.271068813613095 0.361803567901346 no 1206 0.393169053507938 428 6471769
SGTC_689 0833-0039 98 µM 0.270901221795319 0.361878544102704 no 1207 0.393233502648395 453 5374726
SGTC_2754 granisetron 64.02 µM 0.270759604275039 0.361941904214797 no 1208 0.393287965389265 441 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2487 5918373 44.05 µM 0.270225574249881 0.362180864908938 no 1209 0.393493359453728 469 2876279
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.269724557049546 0.362405102307411 no 1210 0.393686083358903 402 94937 An inhibitor of serotonin biosynthesis.
SGTC_1597 7-benzyloxygramine 47.5 µM 0.269664849403248 0.362431828466805 no 1211 0.39370905255323 431 260807
SGTC_2544 sphondin 68.51 µM 0.268791843528144 0.362822677271999 no 1212 0.394044935179271 398 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_464 bw-b 70c 158 µM 0.26860482767526 0.362906423747948 no 1213 0.394116898420899 445 5353454
SGTC_2152 5568786 200 µM 0.267409436957842 0.363441879425381 no 1214 0.3945769671416 443 5399883
SGTC_1212 0520-0165 585 µM 0.267255304533225 0.36351093996702 no 1215 0.394636298637945 447 5403258
SGTC_1009 4106-0057 9.87 µM 0.266650987982281 0.363781752684769 no 1216 0.394868946877917 447 2928005
SGTC_3341 9147222 25.867 µM 0.266564155315743 0.363820670652384 no 1217 0.39490237857824 432 1939759
SGTC_248 streptozotocin 5.23457 mM 0.265216281545688 0.364424960882794 no 1218 0.395421426512102 433 5300 DNA alkylating agent.
SGTC_2319 6033012 152.6 µM 0.26483400302859 0.364596408667647 no 1219 0.395568670610568 402 847246
SGTC_1140 3229-1848 2.98 µM 0.264493862518333 0.364748980786292 no 1220 0.395699696739572 437 2849525
SGTC_448 monastrol 171 µM 0.264062213122751 0.364942630619315 no 1221 0.395865990138785 434 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1451 4152-0210 104 µM 0.263193982787113 0.365332247018866 no 1222 0.396200534200047 442 659563
SGTC_2063 5246145 200 µM 0.262783306355197 0.365516585595921 no 1223 0.396358801532505 437 711240
SGTC_453 enantio-paf c16 10 µM 0.260309358531408 0.366627711889142 no 1224 0.397312577157754 451 13871343 A lipid and platelet activating factor
SGTC_1800 st050079 29.0735 µM 0.260151389242215 0.366698698863305 no 1225 0.397373499634568 433 3645560
SGTC_1386 3228-0095 33.8 µM 0.259313207575792 0.367075430455148 no 1226 0.397696794844604 443 870181
SGTC_3139 9095020 49.47 µM 0.259074100397936 0.367182923755334 no 1227 0.397789033812242 452 25236292
SGTC_2622 2-methoxyxanthone 59.94 µM 0.25862631183329 0.367384260102305 no 1228 0.397961789936138 416 71034 A hepatoprotective.
SGTC_1634 st006576 41 µM 0.25836440163726 0.367502038035643 no 1229 0.398062843753607 456 3915356
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.256333435726936 0.368415761804361 no 1230 0.398846690755063 408 688664
SGTC_1636 st007707 68.9 µM 0.255425075671 0.368824670823209 no 1231 0.39919740268543 471 403051
SGTC_2534 helenine 20.12 µM 0.255069644489446 0.368984712830132 no 1232 0.399334654527673 426 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1958 st076513 41.9 µM 0.254841192325246 0.369087591272631 no 1233 0.399422879245696 442 732122 YGL099W LSG1
SGTC_1382 3002-2117 298 µM 0.25364652366031 0.369625736816605 no 1234 0.399884325505142 456 1497314
SGTC_1605 st000082 49.1 µM 0.253145813050809 0.369851360903072 no 1235 0.400077768903823 449 1114022
SGTC_1642 st009582 77.7 µM 0.252959648957267 0.369935259319631 no 1236 0.400149697372259 449 6739311
SGTC_2114 5491910 81.25 µM 0.252765854621888 0.370022603027337 no 1237 0.400224577545783 461 2849228
SGTC_1654 st012436 41.8 µM 0.252733928974795 0.370036992658777 no 1238 0.400236913645297 449 4323132
SGTC_1172 0370-0043 85 µM 0.251198833573384 0.370729110194297 no 1239 0.400830193165989 409 376585
SGTC_894 0960-0238 55.9 µM 0.251187994482033 0.370733998628833 no 1240 0.400834383043793 449 6741907 YDL195W SEC31
SGTC_1844 rapamycin 4 nM 0.249313776367084 0.371579584874294 no 1241 0.401559037857787 427 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1487 3970-0795 2.82 µM 0.248344930984451 0.372016939769808 no 1242 0.401933768860246 411 3765103
SGTC_2374 9071832 200 µM 0.248141166077859 0.372108944095048 no 1243 0.402012592746047 439 17381698
SGTC_626 0214-0009 33 µM 0.247646437042057 0.372332355484167 no 1244 0.40220398901762 435 3437874
SGTC_107 0358-0022 2.6945 µM 0.247595300856674 0.372355450185143 no 1245 0.402223773458107 450 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1626 st003712 1.76 µM 0.246195208720731 0.372987953675847 no 1246 0.402765562162698 446 24207035
SGTC_2588 indole-3-carbinol 100 µM 0.245793752577366 0.373169378152459 no 1247 0.402920946728477 458 3712 Induces cell cycle arrest.
SGTC_2675 theaflavin digallate 100 µM 0.24533529301405 0.373376597787356 no 1248 0.403098413357462 435 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_3273 9137859 49.47 µM 0.243814586542608 0.374064205467074 no 1249 0.403687211383754 449 2377234
SGTC_2100 5377183 190 µM 0.24359621651333 0.374162977350918 no 1250 0.403771779414619 434 2844202
SGTC_1137 ixabepilone 100 µM 0.243218247976493 0.374333957440675 no 1251 0.403918165694008 423 154225 A novel microtubule stabilizer.
SGTC_841 0251-0215 91.2 µM 0.242223956463863 0.374783859007752 no 1252 0.404303316552286 454 3888614
SGTC_2508 celastrol 40.54 µM 0.242148730181901 0.374817904684017 no 1253 0.404332460143063 399 122724 Celastrol is a natural product and antioxidant.
SGTC_2717 st081029 62.2815 µM 0.241929707359462 0.374917034905142 no 1254 0.404417315312109 470 5292846
SGTC_422 cantharidin 155 µM 0.241073707058277 0.3753045417742 no 1255 0.404748995305495 413 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_98 0074-0023 107.663 µM 0.240834868640701 0.3754126851548 no 1256 0.40484155180156 446 3563821
SGTC_1550 gossypolone 36.6 µM 0.240615017611828 0.375512239911675 no 1257 0.404926754865189 417 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2694 st077685 81.9 µM 0.240366606258013 0.375624737565823 no 1258 0.405023031879877 402 2838096
SGTC_1003 4049-0218 100 µM 0.240129580937247 0.375732088704623 no 1259 0.405114901359083 447 295161
SGTC_3195 9113082 49.47 µM 0.239890333910413 0.375840455832178 no 1260 0.405207637259971 465 17018038
SGTC_899 1083-0020 478 µM 0.23870619809489 0.3763769551099 no 1261 0.405666705146282 462 767123
SGTC_2287 7945887 168.79 µM 0.237762241217317 0.376804807142722 no 1262 0.406032753026324 433 1245853
SGTC_1652 st011932 78 µM 0.237470895434603 0.376936891312038 no 1263 0.406145747788497 439 1551076
SGTC_743 1275-0778 158 µM 0.237359140101661 0.37698756039664 no 1264 0.406189092750314 442 2849257 YMR203W TOM40
SGTC_2629 bisabolol 100 µM 0.236802548366496 0.37723994672166 no 1265 0.406404987234989 465 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3308 9128332 17.569 µM 0.235766999441468 0.377709655503627 no 1266 0.406806738480518 452 17332805 YDL196W YDL196W
SGTC_1307 1187-1599 12.2 µM 0.235419645545881 0.377867250342438 no 1267 0.406941519783573 435 1538471
SGTC_3118 9124250 49.47 µM 0.23460564279646 0.378236643871154 no 1268 0.407257414730826 458 1504786
SGTC_2027 5150920 200 µM 0.234520754495382 0.37827517250208 no 1269 0.407290361322187 456 786715
SGTC_2471 5466956 24.79 µM 0.233610674733301 0.37868831042777 no 1270 0.407643619899039 438 724419
SGTC_793 0488-0545 106 µM 0.232265514384062 0.379299210478795 no 1271 0.408165897798798 475 292548
SGTC_3048 9093155 49.47 µM 0.232246750337487 0.379307734243274 no 1272 0.408173184366657 456 25236002
SGTC_1913 st060213 96.1 µM 0.230575073178136 0.380067346073407 no 1273 0.408822467277648 445 688959
SGTC_3221 9128209 49.47 µM 0.229247522739408 0.380670916289227 no 1274 0.409338269056646 447 16460723
SGTC_2308 7584454 197.62 µM 0.228866415728707 0.380844240164234 no 1275 0.409486372077307 445 893577
SGTC_796 1234-0020 70.7 µM 0.228297855774207 0.381102860311751 no 1276 0.409707345696921 414 46495034
SGTC_985 1493-0307 8.71 µM 0.228241699846713 0.381128406771475 no 1277 0.409729172531612 473 3278274
SGTC_1622 st003707 19.4 µM 0.228141590835434 0.381173949657055 no 1278 0.409768083861225 450 10140899
SGTC_3061 glucosamine 200 µM 0.227401401163933 0.38151073734439 no 1279 0.410055815427558 469 91431 and experimental redox chemotherapeutic
SGTC_1038 k292-0204 154 µM 0.226922868117337 0.38172851855274 no 1280 0.410241859838077 435 4454212
SGTC_588 3970-1144 52.9 µM 0.226665073265449 0.381845856953571 no 1281 0.41034209387617 435 1888707
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.226299596528278 0.382012226651409 no 1282 0.410484206087771 410 2724 A muscle relaxant with antifungal properties.
SGTC_1734 st037168 69.4 µM 0.225696478911745 0.382286821162299 no 1283 0.410718748427754 403 708907
SGTC_1014 4130-3005 69.3 µM 0.224024103437048 0.383048549349552 no 1284 0.411369274004334 430 743608
SGTC_271 rotenone 740 µM 0.223310677588901 0.383373636108484 no 1285 0.411646858784451 455 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1687 st020778 55.3625 µM 0.222932953172368 0.383545787063347 no 1286 0.411793844390189 458 4259299
SGTC_3301 9125354 19.7965 µM 0.221376066470144 0.384255593092323 no 1287 0.412399813166279 416 41905162
SGTC_815 1582-0027 36.9 µM 0.22088764276439 0.38447835230326 no 1288 0.412589959715666 447 3128206
SGTC_1610 st001799 48.1 µM 0.218993261715 0.385342697789503 no 1289 0.413327648374718 435 621897
SGTC_2222 6885208 172.143 µM 0.218887554541382 0.385390945417441 no 1290 0.413368820718911 428 609514
SGTC_310 1273-0058 1.06 µM 0.218588839047384 0.385527296876652 no 1291 0.413485173856848 430 2734232
SGTC_1239 0337-0584 35.4 µM 0.218537559691397 0.385550705237931 no 1292 0.413505148523124 455 914301 YML130C ERO1
SGTC_113 0099-0221 2.5 µM 0.218425401232439 0.385601905573499 no 1293 0.413548837991341 469 89219
SGTC_467 ro 31-8220 72.8 µM 0.216107498451536 0.386660473241918 no 1294 0.414451977449737 442 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_197 4544-0043 41.561 µM 0.215565447418629 0.386908145650685 no 1295 0.414663245755559 440 896523
SGTC_647 0140-0236 81 µM 0.215316286092275 0.387022007189765 no 1296 0.414760366468146 449 990837
SGTC_1225 1216-0074 20.6 µM 0.213451529397092 0.387874470228395 no 1297 0.415487395902285 441 4241466
SGTC_2741 miltefosine 3.04 µM 0.213015023685669 0.388074094604126 no 1298 0.415657622198131 470 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_650 1328-0195 38 µM 0.212171539419531 0.388459923646969 no 1299 0.415986604756589 461 2780821
SGTC_3304 9125678 46.087 µM 0.211970915643705 0.388551709781591 no 1300 0.416064862341342 467 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1010 4112-3296 15.2 µM 0.210929405815022 0.389028304361009 no 1301 0.416471178891534 446 704384
SGTC_2723 salbutamol 83.58 µM 0.210733133531734 0.389118137223486 no 1302 0.416547759159772 461 9884233 β2-adrenoceptor agonist
SGTC_3060 1327-0027 12.5 µM 0.210095003569027 0.389410247122064 no 1303 0.416796762516289 458 16000455 YPR107C YTH1
SGTC_3327 9140648 26.9345 µM 0.209663578855812 0.38960777120027 no 1304 0.416965126771714 473 8029710
SGTC_823 0417-1665 178 µM 0.20812705458128 0.39031148689593 no 1305 0.417564881584343 466 3429856
SGTC_1891 st059073 26.2 µM 0.208036715642656 0.390352872612692 no 1306 0.417600149759811 477 688754
SGTC_744 1594-0068 283 µM 0.205676320068688 0.391434646721302 no 1307 0.418521878465827 432 668392
SGTC_2648 atorvastatin 78.68 µM 0.203403873931482 0.39247690744993 no 1308 0.419409686071075 475 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2303 7774051 200 µM 0.202406156997949 0.392934756000612 no 1309 0.41979960771531 461 2953184
SGTC_849 0386-0493 241 µM 0.20232750704049 0.392970854478757 no 1310 0.419830348565274 449 726119
SGTC_1503 4585-0012 61.3 µM 0.202191097708015 0.393033465332145 no 1311 0.419883666204371 444 2922052
SGTC_2205 7238770 200 µM 0.201068169523281 0.393548985901175 no 1312 0.420322635366562 460 279867
SGTC_1049 3226-0134 66 µM 0.199918133924083 0.394077144579446 no 1313 0.420772303953813 451 5702385
SGTC_2603 homopterocarpin 100 µM 0.19911429828743 0.394446425230444 no 1314 0.421086668377191 448 101795 A weak amylase inhibitor.
SGTC_3159 9100096 49.47 µM 0.198592034437413 0.394686403179288 no 1315 0.421290942551861 430 25236875
SGTC_64 000l-0018 272.079 µM 0.198436796981597 0.394757741819082 no 1316 0.421351664996727 431 6811119
SGTC_2231 micatex 6.853 µM 0.198306062364178 0.394817823032689 no 1317 0.421402804399999 456 20737 An antifungal of unknown mechanism.
SGTC_3081 9117243 49.47 µM 0.197850426514266 0.395027237419373 no 1318 0.421581045633783 452 45595589
SGTC_568 1193-0097 7.48 µM 0.196742233450882 0.395536699511763 no 1319 0.422014629219576 436 3646150
SGTC_2908 7930301 100 µM 0.193309947463528 0.397115730450213 no 1320 0.423358118156379 424 2223178
SGTC_2523 spermine 47.74 µM 0.192922683680028 0.397293998480795 no 1321 0.42350975986786 465 1103 A DNA binding polyamine.
SGTC_1803 st050068 52.4 µM 0.19258198115845 0.397450850842717 no 1322 0.423643178855184 462 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3261 9137475 49.47 µM 0.191296685881641 0.398042723169379 no 1323 0.424146578715367 469 17027690
SGTC_630 4356-0227 183 µM 0.191177887153728 0.398097441284981 no 1324 0.424193113789719 483 779312
SGTC_2066 5222451 176 µM 0.190439068774727 0.398437782382299 no 1325 0.42448254267846 477 2281147
SGTC_1007 4101-0031 70 µM 0.190310073786804 0.398497212623685 no 1326 0.4245330800846 462 1146276
SGTC_344 k064-0035 6.43 µM 0.189945260146873 0.398665301371104 no 1327 0.424676012778044 463 5088750
SGTC_2055 5235184 200 µM 0.189482893939017 0.398878364702728 no 1328 0.424857180451926 474 2836034
SGTC_2078 5212016 200 µM 0.189319577450579 0.398953629906209 no 1329 0.424921176095814 490 1899708
SGTC_2763 lisinopril 49.32 µM 0.189072274521138 0.399067607823847 no 1330 0.425018085632831 490 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_296 1222-0039 74.9 µM 0.188834859741508 0.399177036550154 no 1331 0.425111124606375 437 5984176
SGTC_134 0269-0018 6.916 µM 0.187361569373561 0.399856279307396 no 1332 0.425688576093765 455 4378915
SGTC_3254 9136651 49.47 µM 0.186539033623102 0.400235631493877 no 1333 0.426011035797662 483 16454030
SGTC_1064 honokiol 6.76 µM 0.184627879006887 0.40111741591502 no 1334 0.426760458784634 463 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_78 0336-0123 156.75 µM 0.184618414108145 0.401121784166473 no 1335 0.426764170925267 434 6765896
SGTC_2451 5856223 45.7 µM 0.184567799641284 0.40114514402588 no 1336 0.426784022068536 464 2179896
SGTC_2625 euphol 100 µM 0.184381930770456 0.401230930252159 no 1337 0.426856921978722 492 6708538 A triterpene alcohol.
SGTC_2608 thymoquinone 42.66 µM 0.183852953295918 0.401475101437499 no 1338 0.427064406696779 467 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3083 9117465 49.47 µM 0.182871858604528 0.401928067602561 no 1339 0.427449282049369 473 16420915
SGTC_1529 apigenin 74 µM 0.182739660460766 0.401989112864539 no 1340 0.427501147577903 476 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1067 clotrimazole 1.36 µM 0.182506994636932 0.40209655698869 no 1341 0.427592432809381 451 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1920 st075728 45.7 µM 0.182429846958641 0.402132185104161 no 1342 0.427622702157558 479 3400306
SGTC_3041 9091929 49.47 µM 0.182417914531885 0.402137695775256 no 1343 0.427627383953864 450 25236887
SGTC_293 4049-0273 38.5 µM 0.181857377668767 0.402396586585404 no 1344 0.42784732716937 452 1380311
SGTC_1810 st050138 53 µM 0.181611137376136 0.402510329220544 no 1345 0.427943953922719 488 3444541
SGTC_2441 5730946 39.09 µM 0.18136124961153 0.402625765123667 no 1346 0.428042016392325 435 1774275
SGTC_1383 3049-0032 20.7 µM 0.179600941014817 0.403439181454288 no 1347 0.428732932936272 485 712864
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.178188774022983 0.404092028243239 no 1348 0.429287362836256 440 5282362
SGTC_1745 st081495 74 µM 0.17798417171135 0.404186638384831 no 1349 0.42936770320518 464 13842402 YBL026W LSM2
SGTC_1973 st070275 50.2 µM 0.177251444726909 0.40452550455753 no 1350 0.429655444148071 480 17118334
SGTC_2482 5981709 142.65 µM 0.177092933342157 0.404598821166527 no 1351 0.42971769628683 468 877755
SGTC_3236 9132701 49.47 µM 0.176866175501092 0.404703709777648 no 1352 0.429806753877977 483 24282524
SGTC_2986 9022445 71.43 µM 0.176656777964086 0.404800574326355 no 1353 0.429888996500628 487 6459286
SGTC_2119 5528445 120.635 µM 0.176103487555531 0.405056547255955 no 1354 0.430106320536713 472 791935
SGTC_1277 0873-0036 22 µM 0.17598561140186 0.405111086446251 no 1355 0.430152623231062 446 5965735
SGTC_870 0573-2213 57.6 µM 0.17525445725207 0.405449419536759 no 1356 0.430439847851634 468 3916321
SGTC_2049 5262831 67.185 µM 0.175112780033677 0.405514987204252 no 1357 0.430495508208973 461 763417
SGTC_268 camptothecin 39.6153 µM 0.174678280881953 0.405716088254302 no 1358 0.43066621735848 468 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1274 0865-0114 173 µM 0.172729953683049 0.406618145900977 no 1359 0.431431849016513 433 870624
SGTC_2020 4017018 200 µM 0.172164828285234 0.4068798867469 no 1360 0.431653973964455 467 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.171724510544817 0.407083851098725 no 1361 0.431827057713848 438 6857784
SGTC_1260 0700-1617 7.75 µM 0.170826917079387 0.407499713084704 no 1362 0.432179931696602 478 2853078
SGTC_964 1287-0107 19.4 µM 0.170645429500131 0.407583810369631 no 1363 0.432251287113602 485 51516812 YPR165W RHO1
SGTC_1926 methyl fluorone black 53.6 µM 0.170162844419427 0.407807450211954 no 1364 0.432441035689429 468 72721 Reacts with homocysteine.
SGTC_2314 7727897 200 µM 0.169956157884247 0.407903242192734 no 1365 0.432522307942757 448 900724
SGTC_1042 0350-0096 82 µM 0.169515116573427 0.408107667817776 no 1366 0.432695741559205 430 3122515
SGTC_2670 beta-carotene 100 µM 0.16824845791818 0.408694911558125 no 1367 0.433193910174695 459 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1661 st013063 9.66 µM 0.167768461096929 0.408917499608233 no 1368 0.433382717587886 464 721395
SGTC_3034 9090421 49.47 µM 0.167424530169931 0.409077008140074 no 1369 0.433518012646516 473 17173761
SGTC_2766 oltipraz 83.91 µM 0.167320142894738 0.40912542392518 no 1370 0.433559077906152 447 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3201 9113999 49.47 µM 0.166532627568448 0.409490725459968 no 1371 0.433868904282753 448 16649224
SGTC_1901 st060216 58.6 µM 0.16645947541375 0.409524662247101 no 1372 0.433897686063728 444 688792
SGTC_854 0422-0053 192 µM 0.166039304011316 0.409719601513902 no 1373 0.434063009662663 474 3596728
SGTC_399 oxolinic acid 75 µM 0.165465829568615 0.409985702009936 no 1374 0.434288671564286 463 4628 A DNA gyrase inhibitor.
SGTC_428 3448-4153 16.5 µM 0.165284576659923 0.410069814628584 no 1375 0.434359998948794 426 3834874
SGTC_799 1310-0557 151 µM 0.164416601225781 0.410472666482802 no 1376 0.434701597762961 488 5354492
SGTC_2421 5690543 90.72 µM 0.164152830913405 0.410595108454115 no 1377 0.434805416392046 480 3397993
SGTC_1066 ketoconazole 628 nM 0.163037582944263 0.411112901855838 no 1378 0.43524442181831 486 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2959 9079155 11 µM 0.16186176308704 0.411658985640003 no 1379 0.435707357161441 482 16189457
SGTC_2572 astragaloside iv 100 µM 0.161517046925254 0.411819114004648 no 1380 0.435843093061857 439 45006101 An anti-inflammatory agent.
SGTC_3067 9117431 49.47 µM 0.160850372756622 0.412128840705078 no 1381 0.436105625009086 470 17150885
SGTC_1318 1280-3875 124 µM 0.159868000610525 0.412585335605843 no 1382 0.436492528040697 460 373245
SGTC_2701 st077767 14.721 µM 0.158612267139992 0.413169029905832 no 1383 0.436987181686474 444 5721188
SGTC_1507 4075-3230 155 µM 0.158589570267478 0.413179581713515 no 1384 0.436996123259088 468 659771
SGTC_2844 9010103 25.97 µM 0.158349165729011 0.413291349967458 no 1385 0.437090834081573 484 2480525
SGTC_1499 4480-0877 67.3 µM 0.158173462589013 0.413373041860589 no 1386 0.437160057139223 475 2861909
SGTC_3080 9117754 49.47 µM 0.15773030345862 0.413579102116026 no 1387 0.437334660340211 478 9550191
SGTC_2213 7173844 200 µM 0.157145065678667 0.413851262605548 no 1388 0.437565260745812 468 892728
SGTC_1506 4226-2149 212 µM 0.154906695772552 0.414892580679518 no 1389 0.438447437453537 473 991114
SGTC_2302 7771753 200 µM 0.152728585842016 0.415906439485906 no 1390 0.439306158490386 474 2203047
SGTC_2456 5770359 74.46 µM 0.151591179181331 0.416436098446269 no 1391 0.439754695497035 497 3118787
SGTC_1942 st076330 65.2 µM 0.150891974738062 0.416761774088888 no 1392 0.440030465616646 487 24208414
SGTC_2024 5144227 134 µM 0.150656223150444 0.416871595421269 no 1393 0.440123453919167 467 3475211
SGTC_1729 st035615 45.989 µM 0.149998825304931 0.417177868564913 no 1394 0.440382771022723 486 17385451
SGTC_194 1486-1323 56.904 µM 0.149471002569579 0.417423810731627 no 1395 0.440590994451929 486 5178754
SGTC_2525 harmine 47.85 µM 0.148927668499639 0.417677014244658 no 1396 0.440805354184007 490 5280953 A monoamine oxidase inhibitor
SGTC_5 0352-0601 109.883 µM 0.148692334964486 0.41778669453268 no 1397 0.440898204905904 454 762456
SGTC_1202 1988-0068 29.6 µM 0.147892880899114 0.418159338326603 no 1398 0.441213653321586 480 2850480
SGTC_1774 st048371 48.465 µM 0.147298101343369 0.418436626346412 no 1399 0.441448365520992 487 4242727
SGTC_709 3807-1509 243 µM 0.146846048651039 0.418647401793682 no 1400 0.441626768534137 492 1886677 YPL242C IQG1
SGTC_2964 9083345 53.42 µM 0.145994856555387 0.419044344531577 no 1401 0.441962724398477 490 17741579
SGTC_2263 7948595 193.29 µM 0.145777211335723 0.41914585389264 no 1402 0.44204863320993 466 2971371
SGTC_177 1327-0068 8.361 µM 0.145418155406674 0.419313328729369 no 1403 0.442190365541015 469 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1326 1431-2094 10.8 µM 0.144063011781208 0.419945541265621 no 1404 0.442725356152418 488 616278
SGTC_980 1473-0395 201 µM 0.143586524359557 0.420167885208699 no 1405 0.44291349119206 504 768876
SGTC_3162 9099653 49.47 µM 0.14058621336421 0.42156850676393 no 1406 0.444098420100124 496 25237511
SGTC_2532 xanthone 78.9 µM 0.140030359096108 0.421828103228402 no 1407 0.444318001805815 494 7020 An insecticide.
SGTC_1380 2291-0730 164 µM 0.139256632916052 0.422189507317022 no 1408 0.44462367890941 450 2999191
SGTC_919 tnp00227 403.569 nM 0.139223483121188 0.422204992906125 no 1409 0.444636776183167 480 1269246 A methoxyflavone. YNL221C POP1
SGTC_1738 st035555 74 µM 0.139220654890968 0.42220631409064 no 1410 0.444637893601793 490 5331140
SGTC_986 1493-0483 84 µM 0.139213448606133 0.422209680451363 no 1411 0.444640740768358 488 40079
SGTC_811 0416-0114 265 µM 0.138061083227888 0.422748072056261 no 1412 0.445096071130605 495 6612453
SGTC_3071 9117417 49.47 µM 0.132679837676933 0.42526411524427 no 1413 0.447223294536376 492 45595590 YGL055W OLE1
SGTC_2365 9042475 200 µM 0.132050966921975 0.425558349461829 no 1414 0.447471989452629 488 6464479
SGTC_247 mechlorethamine 29.705 µM 0.131149431272186 0.425980229618666 no 1415 0.447828549162213 497 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.131107497373826 0.42599985495707 no 1416 0.44784513515713 476 3256 An antibiotic and ribosome inhibitor.
SGTC_595 3909-8003 73.7 µM 0.130388759543386 0.426336257410307 no 1417 0.448129429627788 497 699517
SGTC_3039 9090270 49.47 µM 0.12969073462628 0.426663016576514 no 1418 0.448405556675862 493 17173750
SGTC_1603 st002045 67.8 µM 0.129024920887415 0.426974743970377 no 1419 0.448668964813882 490 5887985
SGTC_1130 3454-2858 15.9 µM 0.128030563323313 0.42744037719313 no 1420 0.449062393019504 507 715628 YIL048W NEO1
SGTC_1168 k815-0004 80.5 µM 0.127696735391648 0.427596723312624 no 1421 0.449194486861127 486 642433
SGTC_3292 9120825 59.784 µM 0.127401289774984 0.427735102812403 no 1422 0.449311397733447 506 24824900
SGTC_619 1652-1634 108 µM 0.127145152131569 0.427855078613774 no 1423 0.449412757597755 477 5400454
SGTC_2954 9074818 52.69 µM 0.126753674581138 0.428038461003666 no 1424 0.449567681114545 496 16648742
SGTC_2913 7966556 36.57 µM 0.12668448393292 0.428070874049123 no 1425 0.449595063455535 499 2976516
SGTC_2459 5811157 9.22 µM 0.126559292531565 0.42812952243623 no 1426 0.449644608819414 467 2870684 YBR192W RIM2
SGTC_2735 sertaconazole 140 nM 0.12569568335691 0.428534140411507 no 1427 0.449986409474386 490 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3068 9116768 49.47 µM 0.124442326616081 0.429121496364396 no 1428 0.450482530995069 497 41904888
SGTC_206 4546-0025 72.014 µM 0.124151524946981 0.429257796162497 no 1429 0.4505976513431 504 6620745 YIL048W NEO1
SGTC_3073 9114972 49.47 µM 0.124148534707181 0.429259197742587 no 1430 0.450598835118043 510 41905075
SGTC_2810 7959871 45.46 µM 0.123321086350499 0.429647072129435 no 1431 0.450926421893596 467 2974535
SGTC_1211 1056-0033 32.3 µM 0.123130396203126 0.429736469616249 no 1432 0.451001920864015 499 6741922
SGTC_697 0508-1955 564 µM 0.122266066982357 0.430141721083318 no 1433 0.451344152479774 490 6243113
SGTC_2795 7780010 54.55 µM 0.121880555753474 0.430322496560918 no 1434 0.451496807534942 468 953673
SGTC_2653 dihydrofissinolide 100 µM 0.1206642139735 0.430892964007743 no 1435 0.451978502471746 483 6857746
SGTC_1795 st049545 62.3 µM 0.11996075560544 0.431222953706283 no 1436 0.452257117944122 491 5291882
SGTC_2816 7982706 58.44 µM 0.119442696963042 0.431466003797768 no 1437 0.4524623180541 484 2981853
SGTC_2274 7947094 46.08 µM 0.118197649349373 0.432050230760204 no 1438 0.452955526225077 508 2971028
SGTC_1358 1509-0022 2.48 µM 0.118056247530392 0.432116591665186 no 1439 0.453011545178948 462 3258434
SGTC_2540 epiandrosterone 100 µM 0.116177698145167 0.432998389625751 no 1440 0.453755855676722 499 441302 A steroid.
SGTC_1720 st037298 9.481 µM 0.116076209398971 0.433046038355753 no 1441 0.453796071746002 492 597396
SGTC_552 k242-0005 476 µM 0.115830956274526 0.433161188143617 no 1442 0.453893258039278 503 4088318
SGTC_3173 9105693 49.47 µM 0.114376936238627 0.433843987211554 no 1443 0.454469498107225 480 17096658
SGTC_2045 5106652 78.05 µM 0.114372947015917 0.433845860799097 no 1444 0.454471079201293 512 673349
SGTC_2248 tofa 1.1 µM 0.114103032824251 0.433972632771556 no 1445 0.454578059041184 502 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1026 k007-1105 30.6 µM 0.112913559381967 0.434531379558266 no 1446 0.455049543124834 473 7066794
SGTC_3010 9080089 71.4286 µM 0.112370624332413 0.434786463024452 no 1447 0.45526477308376 474 17027233
SGTC_656 4090-1979 187 µM 0.111582626180903 0.435156731079494 no 1448 0.455577174141247 497 22330961
SGTC_1370 2001-0092 44.6 µM 0.111351114706145 0.435265525536892 no 1449 0.455668961856902 506 790957
SGTC_2621 lithochol-11-enic acid 100 µM 0.110914377270919 0.435470775404752 no 1450 0.455842122267734 496 6708711
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.110837149499069 0.435507071310206 no 1451 0.45587274289515 501 5282309
SGTC_2519 cryptotanshinone 88.04 µM 0.110502836703271 0.435664199620359 no 1452 0.456005300142501 493 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1737 st035557 69.7 µM 0.108626033709876 0.436546492170467 no 1453 0.456749555510057 514 5716916
SGTC_610 4215-0184 155 µM 0.108537766041732 0.436587994961228 no 1454 0.45678456224022 495 5605015
SGTC_2991 9074669 71.4286 µM 0.108048531225458 0.436818042120524 no 1455 0.456978597583634 501 17333109
SGTC_1284 0929-0043 16 µM 0.107240136244424 0.437198211015586 no 1456 0.457299237444837 496 1239883
SGTC_3136 9095672 49.47 µM 0.106732125253415 0.437437146175216 no 1457 0.4575007479517 503 17217380
SGTC_3142 9086498 49.47 µM 0.105940116868736 0.437809700628465 no 1458 0.457814932244695 500 25236367
SGTC_1675 st018485 24.5 µM 0.105908870063498 0.437824400010133 no 1459 0.457827328179818 512 3323024
SGTC_2974 9094440 9.66 µM 0.105645675518758 0.437948217577146 no 1460 0.457931741840965 462 25236134
SGTC_859 0439-0102 54.6 µM 0.104315445860511 0.438574105166321 no 1461 0.458459510381028 483 610143
SGTC_504 lovastatin 124 µM 0.102625823792667 0.439369312144229 no 1462 0.459129973313241 499 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1705 st027868 56.3335 µM 0.100902502692731 0.440180631387366 no 1463 0.459813928194243 507 292948
SGTC_753 1322-0200 289 µM 0.100585336885318 0.440329976782224 no 1464 0.459939818568526 493 5403907
SGTC_1097 itavastatin 7.23 µM 0.100458704392508 0.440389607207955 no 1465 0.459990083028281 515 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2051 5263410 176 µM 0.099500684289212 0.44084077641627 no 1466 0.460370372306544 511 227584
SGTC_94 0334-0113 514.748 µM 0.099259018164822 0.44095459861735 no 1467 0.460466308220852 519 6795178
SGTC_515 4092-1064 102 µM 0.0987050634167586 0.441215523863672 no 1468 0.460686224237981 501 717353
SGTC_2234 tolnaftate 200 µM 0.0977930781892052 0.441645145118102 no 1469 0.461048301921661 505 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.0975694173309271 0.441750518577107 no 1470 0.461137105019118 501 688801
SGTC_2175 5807670 165.306 µM 0.0968090853380617 0.442108764977357 no 1471 0.461439004385596 488 241186
SGTC_3127 9126946 49.47 µM 0.096497464791627 0.442255605245305 no 1472 0.461562743667314 516 27243249
SGTC_1985 st071382 65.5 µM 0.0953926118727875 0.442776292284943 no 1473 0.462001492095012 489 6123237
SGTC_768 0384-0033 77.3 µM 0.094825851505885 0.443043429400717 no 1474 0.462226576429432 473 3965305 YMR134W ERG29
SGTC_1301 naphtanilide LB 4.81 µM 0.0940245149210276 0.443421175945812 no 1475 0.462544841454321 506 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3342 9147791 14.508 µM 0.0939331990729232 0.443464225105522 no 1476 0.462581110687424 505 1838168
SGTC_1093 fluphenazine 7.97 µM 0.0937350683622925 0.443557632441114 no 1477 0.462659806190242 514 6602611 An atypical antipsychotic.
SGTC_1179 1021-1431 9.29 µM 0.0934623433504511 0.443686211865896 no 1478 0.462768132180568 507 2840958
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.0933867639498093 0.443721845715848 no 1479 0.462798152700954 508 6710655
SGTC_1132 3456-3614 2.5 µM 0.0931820067519001 0.443818386042178 no 1480 0.462879484360213 475 3125502
SGTC_2197 6588183 93.1375 µM 0.0919179235170603 0.444414458278256 no 1481 0.463381625419919 490 884136
SGTC_1269 0831-0796 3.05 µM 0.0918205108588678 0.444460397973807 no 1482 0.463420323796602 511 927758
SGTC_147 4466-0538 29.23 µM 0.0916700415119019 0.444531360607819 no 1483 0.463480100275661 465 6742687 YHR072W ERG7
SGTC_3055 9094636 49.47 µM 0.0902076434773898 0.445221132330289 no 1484 0.46406110523842 514 25236176
SGTC_250 brefeldin a 552.239 µM 0.088957287897041 0.445811021260955 no 1485 0.464557927404442 516 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2821 7996764 71.43 µM 0.0878306566670153 0.446342642687939 no 1486 0.465005635708719 497 2987135
SGTC_2023 5144124 124 µM 0.0877714235896407 0.44637059556966 no 1487 0.465029175378662 520 2830192
SGTC_1659 st012954 42.1 µM 0.0870018735168888 0.446733780717973 no 1488 0.465335011452531 497 24207262
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.0856430487249875 0.447375179916713 no 1489 0.465875088110317 518 229346 A bile salt which induces apoptosis.
SGTC_1616 st002734 56.1 µM 0.0852050758975613 0.447581943430981 no 1490 0.466049177638079 489 4026101
SGTC_711 k292-0785 179 µM 0.0850845785121873 0.447638831796429 no 1491 0.466097075204607 518 4146315
SGTC_1766 st045414 44.774 µM 0.0835897501326822 0.448344648697229 no 1492 0.466691308311738 509 253960
SGTC_2388 9080168 200 µM 0.0832147253981602 0.448521750825697 no 1493 0.466840402087703 522 15943073
SGTC_3047 9092122 49.47 µM 0.0829827667505589 0.448631296391891 no 1494 0.466932621243863 504 17173831
SGTC_2022 5136654 200 µM 0.0828339094165213 0.448701598317721 no 1495 0.466991802976692 508 1713771
SGTC_1556 plumbagin 1.48 µM 0.0808594032351229 0.449634264124848 no 1496 0.467776882863469 520 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_692 k241-0027 77.8 µM 0.0808564704523865 0.44963564964464 no 1497 0.467778049055977 508 3600480
SGTC_150 3970-0969 77.2 µM 0.0802390107677486 0.449927366663385 no 1498 0.468023582031998 493 6615640
SGTC_3132 9126706 49.47 µM 0.0787914675234983 0.45061136003345 no 1499 0.468599245439285 525 850858
SGTC_1838 st055369 84.5 µM 0.0782567765600488 0.450864049506301 no 1500 0.468811899640434 492 676036
SGTC_2774 tamoxifen 10.92 µM 0.0769269997319404 0.45149257455465 no 1501 0.469340809252568 518 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1879 gemcitabine 100 µM 0.0754920025112555 0.452170968892387 no 1502 0.469911630225999 504 60750 A nucleoside analog which inhibits DNA replication.
SGTC_488 nitrendipine 139 µM 0.0750219622524272 0.452393210692126 no 1503 0.470098618890815 521 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.0747050979774173 0.45254303710343 no 1504 0.470224675705587 507 2333 A French combination drug.
SGTC_832 4083-0019 164 µM 0.0727345784398189 0.453474930330929 no 1505 0.471008665897726 517 1990758
SGTC_2852 9023854 51.95 µM 0.0723683724713155 0.453648143940985 no 1506 0.471154376945166 528 19798528
SGTC_1091 telmisartan 47.6 µM 0.0721445660906434 0.453754007594299 no 1507 0.471243429996283 518 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2190 6049624 200 µM 0.0716300270159066 0.453997404463916 no 1508 0.471448171671478 530 2265554
SGTC_2164 5685496 200 µM 0.0714439740125385 0.454085418983607 no 1509 0.471522206400306 494 759046
SGTC_809 3998-0021 90 µM 0.0705349735802601 0.454515464464075 no 1510 0.471883932483658 529 715485
SGTC_1128 3448-9350 235 µM 0.0705329493378155 0.454516422187021 no 1511 0.47188473803324 506 619386
SGTC_966 1300-0360 30.2 µM 0.0700837971553301 0.45472893456053 no 1512 0.472063481492895 513 70588
SGTC_2122 5258151 111.688 µM 0.0685344510926536 0.455462092980586 no 1513 0.472680098264831 495 2173356
SGTC_481 bay k-8644 50 µM 0.0680138791967101 0.455708464417411 no 1514 0.472887292933952 509 2303 A calcium channel antagonist.
SGTC_946 3434-1334 87.4 µM 0.0679953732534336 0.455717223052615 no 1515 0.472894658685522 507 4047976
SGTC_2129 girgensonine 121.053 µM 0.0674214898282293 0.45598884567604 no 1516 0.473123080851268 524 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2346 9031566 143.75 µM 0.0670517081608355 0.456163876563269 no 1517 0.473270269313897 518 4771086
SGTC_406 estrone 100 µM 0.0663787324716841 0.45648244182911 no 1518 0.473538150941151 523 5870 A steroid.
SGTC_101 0490-5701 117.494 µM 0.0658200172915265 0.456746941068477 no 1519 0.473760559649257 525 4661669
SGTC_569 4130-2812 160 µM 0.0658016327611545 0.45675564474575 no 1520 0.473767878150104 512 743552
SGTC_2242 6630449 61.2675 µM 0.0657414850966811 0.456784120236524 no 1521 0.473791821751689 497 691249 YDR170C SEC7
SGTC_3125 9127534 49.47 µM 0.0656648325288473 0.456820409905457 no 1522 0.473822335767704 525 1639235
SGTC_1555 citronellol 128 µM 0.0648977509640684 0.45718358955216 no 1523 0.474127705645875 523 8842 A terpine precursor.
SGTC_2499 avocadenofuran 51.48 µM 0.0646286735793511 0.457310994439687 no 1524 0.474234827106931 491 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_540 1187-0821 17.3 µM 0.0634185192877888 0.457884041912132 no 1525 0.474716620337469 531 847520
SGTC_3309 9129340 25.759 µM 0.0618726924204824 0.458616168484619 no 1526 0.47533210705598 514 17158987
SGTC_2765 myclobutanil 7.74 µM 0.0582512646593914 0.460331875925845 no 1527 0.476774243360324 519 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2543 pimpinellin 60.67 µM 0.0580089558050375 0.460446700220375 no 1528 0.476870747420285 515 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2202 7226349 200 µM 0.0566800843480675 0.46107647859617 no 1529 0.47740001944753 511 844334
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.0559488689552754 0.461423057725858 no 1530 0.477691269986604 531 91467 include heat shock
SGTC_1962 st076595 64.5 µM 0.054816217951197 0.46195996576974 no 1531 0.4781424398861 512 279619
SGTC_3352 9151559 45.5865 µM 0.0546835101886103 0.462022877492274 no 1532 0.47819530333374 521 17159339
SGTC_2591 skatole 100 µM 0.0543929789851637 0.462160610643825 no 1533 0.47831103626693 523 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1127 asiatic acid 681.4 nM 0.0529373906922846 0.462850734501709 no 1534 0.478890896342622 501 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1773 st048542 73.5835 µM 0.0529240077152037 0.462857080163899 no 1535 0.478896227904175 522 3237138
SGTC_581 0958-0271 211 µM 0.0527100504455299 0.462958531261852 no 1536 0.478981465531045 512 4591145
SGTC_2306 7482397 179.52 µM 0.0523990833440602 0.463105985342809 no 1537 0.479105352250472 526 891448
SGTC_325 2810-4341 181 µM 0.050898809506699 0.46381745461198 no 1538 0.479703077079008 500 774970
SGTC_346 4513-0042 7.16 µM 0.0503372459209738 0.46408379270606 no 1539 0.479926821712327 499 2827372
SGTC_1916 st067606 49.2 µM 0.0502675513130527 0.464116848554735 no 1540 0.479954590683555 517 19590279
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.0477093150161057 0.465330378420529 no 1541 0.480973955124544 512 16725076
SGTC_716 1683-5115 658 µM 0.0476387449862339 0.465363858777497 no 1542 0.481002076517682 535 723597
SGTC_1296 1068-0102 11.9 µM 0.045971292286389 0.46615501487441 no 1543 0.481666565573217 526 767053
SGTC_2424 5537928 59.2 µM 0.0450848159809976 0.466575675848956 no 1544 0.482019852103836 530 5382802
SGTC_686 1319-0111 510 µM 0.0440452331228666 0.467069038250365 no 1545 0.482434174006711 522 4562600
SGTC_635 k038-0028 24.7 µM 0.0438346120469674 0.467169000415495 no 1546 0.482518118583147 524 4035102
SGTC_531 3788-1495 174 µM 0.0436050822311949 0.467277939152117 no 1547 0.482609600259095 518 2896655
SGTC_600 1495-0418 41.6 µM 0.0430416367549796 0.467545370291069 no 1548 0.482834171629853 528 5377768
SGTC_60 0986-0278 202 µM 0.042475830125716 0.467813936858316 no 1549 0.483059689561269 524 3110598
SGTC_1228 0124-0032 52.5 µM 0.0420396135128414 0.468021002054984 no 1550 0.483233559499773 525 X1228
SGTC_2098 5376439 882.5 nM 0.0406780677645981 0.468667361902211 no 1551 0.4837762732545 519 2844116
SGTC_3091 9116372 49.47 µM 0.0401418887144596 0.468921922280708 no 1552 0.483990003166771 508 17169793
SGTC_1935 st074532 41.6 µM 0.0392610087243727 0.469340162992617 no 1553 0.484341146581347 527 2829742
SGTC_2930 9013230 14.89 µM 0.0388664663738887 0.469527502202783 no 1554 0.484498426157156 525 2995857
SGTC_1872 amphotericin b 148 nM 0.0388645476449955 0.469528413282852 no 1555 0.484499191041328 529 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2800 7887935 81.82 µM 0.0373603523751354 0.470242706892618 no 1556 0.485098842403328 521 2961002
SGTC_1959 st077091 55.8 µM 0.0368818771059473 0.470469939484015 no 1557 0.485289594944907 537 821356 YKL052C ASK1
SGTC_3086 9117350 49.47 µM 0.0348988282704732 0.471411810487099 no 1558 0.486080207475119 533 2679265
SGTC_1426 4048-4480 71.7 µM 0.0339413252742704 0.471866644713054 no 1559 0.486461969677549 524 14224343
SGTC_17 0960-0276 49.807 µM 0.0335839904317415 0.472036395773829 no 1560 0.486604444425893 532 6821114
SGTC_542 3381-0244 89.3 µM 0.0335578814121178 0.472048799000552 no 1561 0.486614854549922 539 1112843
SGTC_3188 9110789 49.47 µM 0.0329664774412706 0.472329755796782 no 1562 0.486850660114763 513 849217
SGTC_445 e6 berbamine 66 µM 0.0317251961451182 0.472919492788852 no 1563 0.487345600689607 535 6610268 A calcium/calmodulin antagonist.
SGTC_1842 st055362 61.2 µM 0.0312863823465713 0.473127988995725 no 1564 0.487520575202973 530 676032
SGTC_1073 triclabendazole 3.09 µM 0.0309568423107511 0.473284570154136 no 1565 0.487651979004452 530 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_960 1222-0186 7.7 µM 0.0307332154196953 0.473390828966741 no 1566 0.487741150796326 529 3126296
SGTC_1873 rapamycin 2 nM 0.0302975642110155 0.473597838929989 no 1567 0.48791486958026 533 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1144 3486-0183 12.5 µM 0.0292756121633375 0.474083471469073 no 1568 0.488322388619023 537 6744069
SGTC_1234 0326-0494 15.5 µM 0.0282031490446013 0.474593148319688 no 1569 0.488750062825114 538 1547813
SGTC_1945 st075991 56.6 µM 0.027672438366021 0.474845378436794 no 1570 0.488961703140076 529 1084980
SGTC_306 1672-3436 11.6 µM 0.0276408433881416 0.474860394856435 no 1571 0.488974302892967 533 6797378
SGTC_822 1487-0950 154 µM 0.0273255089939284 0.475010268527081 no 1572 0.489100055613708 536 1958375
SGTC_683 panaxydol 45 µM 0.0272786201852399 0.475032554371548 no 1573 0.489118754571544 527 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1052 3253-3998 198 µM 0.0272342219576113 0.475053656536423 no 1574 0.489136460323585 528 5450317
SGTC_435 c-PAF 6.7 µM 0.0270413291950118 0.475145337919568 no 1575 0.489213385070878 536 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_210 3551-0445 56.827 µM 0.0267007920524715 0.475307197467497 no 1576 0.489349190696086 528 2865180 YOR207C RET1
SGTC_142 0335-0849 62.6745 µM 0.0251085889025188 0.476064035754457 no 1577 0.489984174694838 538 3889043 YPR107C YTH1
SGTC_2146 5545642 200 µM 0.025003903780443 0.476113799864956 no 1578 0.490025924908372 539 825326
SGTC_3279 9140807 49.47 µM 0.0241003516491595 0.476543336361777 no 1579 0.490386281414756 538 45595718
SGTC_1682 st012968 530 nM 0.0235945854147454 0.476783782738818 no 1580 0.490587995581758 523 24207270
SGTC_2188 6126565 140.678 µM 0.023335813979482 0.476906808567538 no 1581 0.490691202030505 537 874518
SGTC_1425 4048-4433 7.33 µM 0.0231746339909188 0.476983438314984 no 1582 0.490755486157674 542 23734946
SGTC_326 k292-0812 17.5 µM 0.0227043766983741 0.477207017434243 no 1583 0.490943042318131 537 3579357
SGTC_3004 9076122 71.4286 µM 0.0224199814684157 0.477342233783625 no 1584 0.491056470725175 535 44782551
SGTC_424 splitomicin 100 mM 0.0220704704347229 0.477508413158996 no 1585 0.491195870957897 524 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2642 cholecalciferol 100 µM 0.0219599114160997 0.477560980637413 no 1586 0.491239966937619 535 9821465 A vitamin D precursor, similar to steriods.
SGTC_3287 9117173 37.0625 µM 0.0218124874874427 0.477631076875794 no 1587 0.491298766491502 535 2789709
SGTC_2465 5809242 33.21 µM 0.0217060798715885 0.477681671355856 no 1588 0.49134120694015 540 2731748
SGTC_2301 7769476 200 µM 0.0200855664639333 0.478452233801843 no 1589 0.491987557058629 533 977820
SGTC_1812 st052057 4.327 µM 0.0199797017494703 0.478502575851425 no 1590 0.492029782495691 532 3645418
SGTC_11 0438-0307 1.3 µM 0.0195699978440246 0.478697406355965 no 1591 0.492193198750224 531 4011476
SGTC_2755 lomerizine 42.69 µM 0.0191398909855542 0.478901944752551 no 1592 0.492364754423259 530 3949 A calcium channel blocker.
SGTC_2085 5307070 144.047 µM 0.0188345746247398 0.47904714208986 no 1593 0.492486536073978 536 2840351
SGTC_2752 diclazuril 33.15 µM 0.0187435258331175 0.47909044211701 no 1594 0.492522852875526 537 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2685 mycophenolic acid 18.85 µM 0.0185038019945911 0.479204448638878 no 1595 0.492618472266312 541 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2738 aclarubicin 5.55 µM 0.0174792936058252 0.479691697664919 no 1596 0.493027125816277 535 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_3223 9129970 49.47 µM 0.0172599892730203 0.479796001240342 no 1597 0.493114602389702 538 17248386
SGTC_1937 st074714 47.2 µM 0.0171980401450555 0.479825465184272 no 1598 0.493139312848292 522 17250970
SGTC_3179 9107801 49.47 µM 0.0169448372573772 0.479945893458563 no 1599 0.493240311467148 534 4818259
SGTC_2408 sulbentine 18.36 µM 0.0168211599678168 0.480004717476525 no 1600 0.493289644535705 521 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1229 0139-0193 12.2 µM 0.0161385223103913 0.480329404851831 no 1601 0.493561940575867 526 3090752
SGTC_2892 9047358 58.44 µM 0.0150679276492581 0.480838644935075 no 1602 0.493988994042455 534 6466771
SGTC_185 k048-0037 25.491 µM 0.0149593530635043 0.480890291387051 no 1603 0.49403230415374 544 6827589
SGTC_2084 5306078 60.6385 µM 0.0140800260735558 0.481308578906457 no 1604 0.494383067880833 535 679340
SGTC_1957 st077035 62.4 µM 0.0132470174861783 0.481704852189755 no 1605 0.494715359197185 542 705593
SGTC_2931 9014674 55.67 µM 0.0130028758757285 0.481820997049534 no 1606 0.494812749218987 537 2996810
SGTC_3020 9089140 49.47 µM 0.0126837355248572 0.481972823192241 no 1607 0.494940057297593 542 17217859
SGTC_366 0181-0206 4.31 µM 0.0126262657463194 0.482000163839189 no 1608 0.494962982586289 533 274874
SGTC_1925 st057770 10.1 µM 0.0119670849013867 0.482313768264131 no 1609 0.495225937809755 530 5989122
SGTC_79 0052-0007 94.094 µM 0.0119281505592602 0.482332291570666 no 1610 0.495241469256426 544 2801472
SGTC_2275 7947463 200 µM 0.0118597598158201 0.482364829074313 no 1611 0.495268751285756 543 1225414
SGTC_1539 benzyladenosine 56 µM 0.0116360327500423 0.482471270032516 no 1612 0.49535799931247 539 92208 A nucleotide analog.
SGTC_2446 5162541 200 µM 0.011327950938689 0.482617845862475 no 1613 0.495480898070839 544 1549321
SGTC_557 1315-0110 16.2 µM 0.0106292341964545 0.482950282427734 no 1614 0.495759628917521 540 6833801
SGTC_2737 bleomycin 30.5 nM 0.00973302190412987 0.483376701061933 no 1615 0.496117147351348 546 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_348 k064-0012 10.7 µM 0.00952455483590326 0.483475892628807 no 1616 0.49620030982355 543 5066323
SGTC_2994 9053520 71.4286 µM 0.00934798998607063 0.483559905471056 no 1617 0.496270745871293 538 4647384
SGTC_1459 k035-0031 35.7 µM 0.00910900297152984 0.483673621103148 no 1618 0.496366083835811 540 3877128 YMR208W ERG12
SGTC_1756 st041558 35.5 µM 0.00853793973577826 0.483945351757907 no 1619 0.496593896234054 540 3955792
SGTC_1214 0358-0031 63.7 µM 0.00769118778935233 0.484348277849109 no 1620 0.496931690255005 539 4301366
SGTC_2935 9038016 29.96 µM 0.0066524093171244 0.484842601364463 no 1621 0.497346092231459 545 6463195
SGTC_1896 st058441 89 µM 0.00648398697861565 0.484922750717941 no 1622 0.497413281573844 544 688759
SGTC_1085 doxorubicin 7.67 µM 0.00530261679793202 0.485484961823571 no 1623 0.497884571876054 544 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1096 rimcazole 32.2 µM 0.00404200287671521 0.486084916620873 no 1624 0.498387478545814 546 18528119 A dopamine reuptake inhibitor.
SGTC_2711 st079103 59.1 µM 0.00353229082354279 0.486327509183073 no 1625 0.498590822774218 547 54693780
SGTC_3177 9107506 49.47 µM 0.00346166202616313 0.48636112468283 no 1626 0.498618999415416 546 8897194
SGTC_1469 k284-2957 126 µM 0.00186256051759728 0.48712223626428 no 1627 0.499256946289349 547 23884841
SGTC_1794 st048918 76.9 µM 0.00141343890913509 0.487336009648282 no 1628 0.499436119646136 546 672303
SGTC_896 0964-0007 44.5 µM 0.000560866465987997 0.487741827952046 no 1629 0.499776246664789 544 6756758
SGTC_667 1498-1044 59 µM 0.000167826593425172 0.487928916382642 no 1630 0.499933046876421 548 6739982
SGTC_2565 isoliquiritigenin 100 µM 0.000142406546885576 0.487941016510555 no 1631 0.499943188007633 548 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2450 5739737 12.93 µM -1.10542210738799e-05 0.488014065192921 no 1632 0.499995590003837 547 2262825
SGTC_298 1391-0729 10 µM -0.000229163101527068 0.488117887639704 no 1633 0.499908577150493 548 3237558
SGTC_1490 4089-0339 670 nM -0.000543890747674546 0.488267703196888 no 1634 0.499783018995531 549 742542
SGTC_3296 9122258 64.045 µM -0.00055700540547046 0.488273946026659 no 1635 0.499777787004836 549 4730474
SGTC_1510 1123-0200 71.5 µM -0.000682070916552847 0.488333479763503 no 1636 0.499727893094253 549 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2944 9067346 25.62 µM -0.000914718146718912 0.488444225285758 no 1637 0.499635080307512 550 6473075
SGTC_1106 tegaserod maleate 11.7 µM -0.0014201066296527 0.48868480508129 no 1638 0.499433459613177 549 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2761 levamisole 97.89 µM -0.00225525239071249 0.48908236803011 no 1639 0.499100285231051 550 26879 An alkaline phosphatase inhibitor.
SGTC_975 1335-0046 28.5 µM -0.00293425148632339 0.489405606903626 no 1640 0.498829404700547 551 16486740
SGTC_95 0471-0001 561.058 µM -0.00600807340334321 0.490868989888844 no 1641 0.497603139915548 553 4015405
SGTC_2012 4023501 200 µM -0.00603876030451771 0.490883599939696 no 1642 0.497590897835298 553 3477460
SGTC_853 0419-0306 21 µM -0.00670470246886906 0.491200658356897 no 1643 0.497325230747504 550 762713
SGTC_2264 7948757 110.76 µM -0.00706716980860724 0.491373233231635 no 1644 0.497180630629438 551 2971411
SGTC_1827 berberine 7.24 µM -0.00735566150898008 0.49151058860821 no 1645 0.497065542085614 551 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1883 5-benzylidenerhodanine 20 µM -0.00873883263298344 0.492169151547476 no 1646 0.496513754553872 551 1273210
SGTC_511 blebbistatin 171 µM -0.00900027278558922 0.492293632304393 no 1647 0.496409459125988 555 3476986 A myosin inhibitor.
SGTC_1481 3346-2004 36 µM -0.00915604728828065 0.492367802324932 no 1648 0.496347316651445 554 2770522
SGTC_2010 4012422 159 µM -0.00929953138739059 0.492436120661831 no 1649 0.496290077214874 558 952393
SGTC_169 k015-0017 16.025 µM -0.0096665000039481 0.492610849637952 no 1650 0.49614368450149 552 1840002
SGTC_1369 1866-0067 208 µM -0.0103025885326446 0.492913721103568 no 1651 0.495889934546217 554 3531355
SGTC_1015 4130-4525 82 µM -0.0109045924665393 0.493200367066787 no 1652 0.495649783228867 562 1363237
SGTC_1496 4469-0713 57.4 µM -0.0114172320106412 0.493444464683847 no 1653 0.495445282379677 553 746691
SGTC_1750 st081859 2.357 µM -0.0126132307904362 0.494013958916474 no 1654 0.494968182367244 559 5291695
SGTC_640 3381-0960 37.1 µM -0.0142048783849141 0.494771866477912 no 1655 0.494333263995919 561 1745025
SGTC_2942 9052777 62.25 µM -0.0142346717145268 0.494786053594359 no 1656 0.494321379378671 557 6469503
SGTC_2787 5284540 71.43 µM -0.01598322326475 0.495618697374376 no 1657 0.49362388794099 558 736958
SGTC_2811 7967822 32.47 µM -0.016118076041865 0.495682913835914 no 1658 0.493570096396035 558 2232244
SGTC_1983 st071813 46.9 µM -0.0171525006900905 0.496175507145023 no 1659 0.493157477782869 571 11838595
SGTC_1384 3089-0840 101 µM -0.0171776818651765 0.496187498503447 no 1660 0.493147433427302 553 1069836
SGTC_2817 7995342 71.43 µM -0.0179514321730719 0.496555962572547 no 1661 0.492838799335296 564 18879975
SGTC_2567 aureobasidin a 60 nM -0.0182159779342862 0.496681941380418 no 1662 0.492733278101563 554 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_277 nystatin 15.5 µM -0.0185412072813674 0.49683681864948 no 1663 0.492603552275525 569 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_178 4092-0806 87.505 µM -0.0196131075022338 0.497347270848652 no 1664 0.492176003785151 555 2169044
SGTC_2091 4-phenylthiadiazole 200 µM -0.0199089430445324 0.497488152208699 no 1665 0.492058005521012 555 270010
SGTC_1475 4092-1048 11.7 µM -0.0206445458834241 0.497838458727401 no 1666 0.491764602775545 559 2881759
SGTC_1683 st010134 710 nM -0.0209414082242129 0.497979830084399 no 1667 0.491646197435697 575 3818134
SGTC_3264 9137442 49.47 µM -0.0211068172229852 0.498058601031104 no 1668 0.491580223374921 563 17015726
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.021440628705488 0.498217568706959 no 1669 0.491447081992878 561 16486 A toxic proline analog.
SGTC_3037 9091026 49.47 µM -0.0215736316515268 0.498280907438887 no 1670 0.491394033764648 566 25236398 YIL048W NEO1
SGTC_764 1951-2361 146 µM -0.0222437829971575 0.498600047886734 no 1671 0.491126746219176 573 5438930
SGTC_2137 5261020 140 µM -0.0224058451652474 0.498677225510246 no 1672 0.491062108877888 561 763655
SGTC_1092 toremifene 6.32 µM -0.0225784220955545 0.498759410552693 no 1673 0.490993278056675 561 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_309 k408-0051 1.48 µM -0.0239452782653762 0.499410339990707 no 1674 0.490448128895519 557 3640463
SGTC_803 4488-1585 147 µM -0.0243023444028015 0.499580383712111 no 1675 0.490305721560749 560 747204
SGTC_456 gingerol 170 µM -0.02446787201623 0.499659212081244 no 1676 0.490239705227934 563 442793 A herb.
SGTC_765 1319-0117 244 µM -0.0248802916343665 0.499855616618837 no 1677 0.49007522368281 562 3487746 YGL099W LSG1
SGTC_1367 1812-0510 76.9 µM -0.0251834746939033 0.5 no 1678 0.489954309030326 563 1142582 YDR527W RBA50
SGTC_2185 6113692 200 µM -0.0256728226031897 0.499766960253848 no 1679 0.48975915056546 563 874150
SGTC_1991 st073000 8.92 µM -0.0258584558116038 0.499678557081236 no 1680 0.489685118208025 569 4301969 YIL048W NEO1
SGTC_1437 4092-1038 11.6 µM -0.0267797234581578 0.499239826724894 no 1681 0.489317712877098 560 3977136
SGTC_1784 st039334 36.3 µM -0.026978660714772 0.499145088003321 no 1682 0.489238377059302 559 3496984
SGTC_1321 1326-2144 215 µM -0.0272770937094925 0.499002967102702 no 1683 0.489119363320738 559 3513030
SGTC_1258 0671-0043 57.1 µM -0.0276517858160033 0.498824529977933 no 1684 0.488969939163801 564 4298767
SGTC_3129 9127257 49.47 µM -0.0277761337501154 0.498765312640194 no 1685 0.488920350562691 583 837894
SGTC_1139 k015-0024 46.9 µM -0.0281617778905669 0.498581660235846 no 1686 0.488766560974507 564 2766652
SGTC_157 1348-1695 65.819 µM -0.0286891250568468 0.498330526161064 no 1687 0.488556264873315 561 5380510
SGTC_3238 9133470 49.47 µM -0.0289685065212236 0.498197478954191 no 1688 0.488444854101578 580 3534688
SGTC_1953 st076800 12.1 µM -0.0289953248632128 0.498184707517754 no 1689 0.488434159623433 560 297591
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.0290562362768542 0.498155700278531 no 1690 0.488409869719404 558 5355888
SGTC_2356 9061756 188.97 µM -0.0296001442876607 0.497896680803898 no 1691 0.488192975120136 562 20104043
SGTC_287 k060-0039 29.6 µM -0.0296560860774579 0.497870040294159 no 1692 0.48817066736825 558 5861974
SGTC_668 1682-0499 62.6 µM -0.030600756950376 0.497420172170161 no 1693 0.487793969237334 563 682214
SGTC_1955 wogonin 32.4 µM -0.0308626777126788 0.497295441663844 no 1694 0.487689527302571 564 5281703 A flavanone.
SGTC_455 paf C-16 10 µM -0.0313172609358235 0.497078963104291 no 1695 0.487508262461676 574 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2721 ifenprodil 61.44 µM -0.0319852977689596 0.496760836683699 no 1696 0.487241887789983 568 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_431 k089-0097 107 µM -0.0322369866949759 0.496640980197399 no 1697 0.487141530190129 578 5499420
SGTC_3174 9107204 49.47 µM -0.0322499741556273 0.49663479546223 no 1698 0.487136351635581 574 3938802
SGTC_1331 1472-0049 76.2 µM -0.0324357375811773 0.496546333486253 no 1699 0.487062281502131 559 24051409
SGTC_1936 st074407 74.3 µM -0.0324761814568737 0.496527073823077 no 1700 0.487046155225994 561 809813
SGTC_2946 9065502 71.43 µM -0.0328418883774283 0.496352921942115 no 1701 0.486900337060445 562 16489101
SGTC_1646 st011709 75.6 µM -0.033010686254426 0.496272539589118 no 1702 0.486833032943994 560 5757843
SGTC_410 α-linolenic acid 100 µM -0.0331781001007066 0.496192816467612 no 1703 0.486766281047113 562 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2259 7964009 200 µM -0.0349648534385914 0.495341967723489 no 1704 0.486053883309706 576 313134
SGTC_1162 k048-0130 20.1 µM -0.0352768512203844 0.495193397001618 no 1705 0.485929490944714 585 6797406
SGTC_2368 9071271 200 µM -0.0362224065400661 0.494743135661353 no 1706 0.485552509937897 573 27209959
SGTC_3151 9099821 49.47 µM -0.0370763994592324 0.494336480903959 no 1707 0.485212044795186 586 17174189
SGTC_2985 9022375 71.43 µM -0.0373666261593402 0.494198281933606 no 1708 0.485096341271988 594 4939335
SGTC_2207 7258803 200 µM -0.0374887800266166 0.494140115408868 no 1709 0.485047643050632 567 3666799
SGTC_187 1488-2104 32.728 µM -0.0384722388448351 0.493671822300155 no 1710 0.484655582642115 564 2852859
SGTC_1744 st037937 38.9 µM -0.0385656735347753 0.493627331992642 no 1711 0.484618335236281 572 1016152
SGTC_2965 9082772 38.63 µM -0.0390368792528728 0.493402961650221 no 1712 0.484430492809591 561 16459634
SGTC_1071 trifluoperazine 6.31 µM -0.0392776809229923 0.493288301803128 no 1713 0.484334500462814 575 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_952 1185-0122 232 µM -0.0403445847668337 0.492780292893822 no 1714 0.483909204595418 556 678600
SGTC_2840 9008771 71.43 µM -0.0411575440043852 0.492393208154612 no 1715 0.483585149974503 559 2992978
SGTC_947 3447-0010 211 µM -0.0419253315220314 0.492027638178246 no 1716 0.483279111256954 576 748350
SGTC_530 4358-1714 28 µM -0.0423648976433591 0.491818348662858 no 1717 0.483103905417891 571 1564641
SGTC_295 k015-0027 31 µM -0.0424922579167809 0.491757709353447 no 1718 0.483053141732576 567 3887424
SGTC_2470 5664817 21.68 µM -0.0427014336050377 0.491658116158369 no 1719 0.482969768381081 564 2859561
SGTC_2016 5121758 140 µM -0.0427161071138149 0.491651129794101 no 1720 0.48296391983445 575 2795203
SGTC_920 mycophenolic acid 780.421 nM -0.0431167770974738 0.491460363436179 no 1721 0.482804222772988 563 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_311 1315-0136 58 µM -0.0432238966848253 0.491409362157034 no 1722 0.48276152804371 577 6759207
SGTC_256 clotrimazole 625 nM -0.0438472546204184 0.491112574692487 no 1723 0.482513079770759 569 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2455 5377712 9.75 µM -0.0444569571728269 0.490822293462327 no 1724 0.482270080615667 565 2243908
SGTC_1695 st026914 34.495 µM -0.0460586645663509 0.49005973927969 no 1725 0.481631745959283 575 3289191
SGTC_891 0929-0073 133 µM -0.0462035886135495 0.489990744384171 no 1726 0.481573991115653 594 5603632
SGTC_932 2857-0803 154 µM -0.0470681859884407 0.489579136410746 no 1727 0.481229441563244 599 674898
SGTC_1677 st019204 53.9 µM -0.0471010661019849 0.489563483425547 no 1728 0.481216338827954 568 3945625
SGTC_1215 3852-0577 11.2 µM -0.0471140954313775 0.489557280656396 no 1729 0.481211146641824 574 2884876
SGTC_1772 st048439 82.2 µM -0.0471145794673941 0.48955705022527 no 1730 0.481210953753594 567 2927068 YDL195W SEC31
SGTC_1294 1000-1494 117 µM -0.0484507213599682 0.488920977476834 no 1731 0.480678518469909 573 712797 YDL207W GLE1
SGTC_2845 9003024 42.97 µM -0.0488362968735114 0.488737428728451 no 1732 0.480524877975164 575 2990173
SGTC_3038 9091290 49.47 µM -0.0498932736901278 0.488234279529296 no 1733 0.480103718723651 574 25236843
SGTC_2968 9090663 33.37 µM -0.0504432027312302 0.487972505970828 no 1734 0.479884604693071 584 25236811
SGTC_2412 st077135 33.4 µM -0.0513428542339563 0.487544271079668 no 1735 0.479526160187412 625 13258915
SGTC_2377 9073351 62.6 µM -0.0514862761684055 0.487476003429595 no 1736 0.479469018689367 613 7337946 YHR072W ERG7
SGTC_1882 5615643 20 µM -0.051589807463542 0.487426723620604 no 1737 0.479427770495906 573 2253075
SGTC_2863 9028737 58.44 µM -0.0520221370166472 0.487220941377778 no 1738 0.479255527252868 595 6460917
SGTC_681 1642-0006 26.6 µM -0.0530686013116888 0.486722854600302 no 1739 0.478838624354841 563 4446530
SGTC_2640 pentamidine 10.38 µM -0.0535802596563031 0.486479327498066 no 1740 0.478634792214206 582 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_438 sphingosine 6.67 µM -0.0537109924783604 0.486417105169973 no 1741 0.478582712357122 574 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2176 5809774 33.9695 µM -0.053810468353487 0.486369759817131 no 1742 0.478543084532557 581 2870539
SGTC_2847 9005661 71.43 µM -0.0542615358983481 0.486155077500907 no 1743 0.478363397144367 570 2991449
SGTC_912 3474-0017 2.18 µM -0.0543488065386169 0.48611354213593 no 1744 0.478328632495321 570 3360550
SGTC_2154 5570129 200 µM -0.054439466338238 0.486070393902673 no 1745 0.478292517934145 575 673366
SGTC_1290 0986-0249 10.2 µM -0.0548584596053217 0.485870982184128 no 1746 0.478125613223319 566 53329
SGTC_1666 st014829 29 µM -0.0549356578539608 0.485834241559016 no 1747 0.478094861950258 578 3858230
SGTC_173 1273-0061 2.693 µM -0.055488318525175 0.48557121971145 no 1748 0.47787471803978 581 2847414 YPL266W DIM1
SGTC_2294 7971431 200 µM -0.0561328271651517 0.48526449358488 no 1749 0.477617996429958 587 5741572
SGTC_955 1216-0110 33 µM -0.0567601143592332 0.484965971634094 no 1750 0.477368143408958 571 3619719
SGTC_973 1325-0077 65.9 µM -0.0571316806059923 0.484789149604221 no 1751 0.477220150077643 572 2835149
SGTC_577 r071-0003 38.6 µM -0.0577224423209581 0.484508022367493 no 1752 0.476984858555488 568 4568517 YMR134W ERG29
SGTC_1564 D-Arginine 115 µM -0.0577229788065902 0.484507767072229 no 1753 0.476984644884949 601 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2593 nobiletin 86.24 µM -0.0584875334903413 0.484143948007315 no 1754 0.476680146164892 570 72344 An anti-infammatory.
SGTC_2949 9072542 2.23 µM -0.0588134973076149 0.483988839682841 no 1755 0.476550328887118 587 16457352
SGTC_1458 k015-0034 6.33 µM -0.0589506184912736 0.483923591945613 no 1756 0.476495720198366 604 3598957
SGTC_718 1130-0073 349 µM -0.0589693885708817 0.483914660425322 no 1757 0.476488245024209 591 6740020
SGTC_1921 5740136 50 µM -0.0599910000920484 0.483428550965515 no 1758 0.476081401333677 576 1774243
SGTC_165 k038-0023 64.381 µM -0.0604257330595353 0.483221701087558 no 1759 0.475908282040985 573 46368543
SGTC_2963 9082507 9 µM -0.0610984407969252 0.482901629582141 no 1760 0.475640405448311 579 16459611
SGTC_769 0302-0231 76 µM -0.0619672647635924 0.482488263137247 no 1761 0.47529445040838 576 571869 YER009W NTF2
SGTC_1199 1638-0010 4.46 µM -0.0627776196649156 0.482102731885511 no 1762 0.474971793814678 577 3111136
SGTC_2081 5214970 32.255 µM -0.0631981386082525 0.481902674024662 no 1763 0.474804363496983 586 2063512
SGTC_2790 5423970 71.43 µM -0.063255277472713 0.481875491107551 no 1764 0.474781613905646 578 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1819 st053448 58.6 µM -0.0635633722198176 0.481728921327093 no 1765 0.474658948735718 568 2857616
SGTC_2003 4023581 200 µM -0.0637184851325515 0.481655130461802 no 1766 0.474597192824271 585 16641307
SGTC_1516 st013856 110 µM -0.0638727810104891 0.481581728902747 no 1767 0.474535762808689 602 5281404 A mutagen and neurotoxin.
SGTC_906 1165-0455 526 µM -0.0654550186416226 0.480829064068907 no 1768 0.473905859707884 602 3252859
SGTC_1131 3454-3128 32.3 µM -0.0656487971320445 0.480736888971047 no 1769 0.473828719191746 571 710982
SGTC_548 1436-0017 110 µM -0.0658284104817184 0.480651452760653 no 1770 0.473757218496985 578 9677137
SGTC_1299 1079-1439 3.74 µM -0.065849431825583 0.480641453651237 no 1771 0.473748850350764 591 323161
SGTC_2030 5175110 200 µM -0.0660285789903108 0.480556240179125 no 1772 0.473677536176398 592 2831986
SGTC_3031 9088762 49.47 µM -0.066783589686141 0.480197120202232 no 1773 0.473376993886772 588 205253
SGTC_624 k048-0052 28 µM -0.067450518650597 0.479879909560288 no 1774 0.473111526329325 578 6835531
SGTC_957 1187-1561 14.1 µM -0.0678078254329773 0.479709969383021 no 1775 0.472969307153949 567 1538454
SGTC_2933 9026794 32.47 µM -0.0678924362416781 0.479669727820368 no 1776 0.47293562993318 577 17586027
SGTC_259 usnic acid 108.925 µM -0.0680079717804063 0.479614778548886 no 1777 0.472889644207898 616 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1045 1348-1485 165 µM -0.0681121200576024 0.479565245447084 no 1778 0.472848191176721 581 6810614
SGTC_935 2996-0153 430 µM -0.0682550475628975 0.479497269390796 no 1779 0.47279130374056 578 23738523
SGTC_486 niguldipine 82 µM -0.0684312792164525 0.479413454764517 no 1780 0.472721161484136 572 1236 A calcium channel blocker.
SGTC_2731 amoxapine 43.43 µM -0.0686058418213087 0.479330434824293 no 1781 0.472651684362496 564 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1148 3909-7663 27.7 µM -0.0696248763770484 0.478845811879127 no 1782 0.472246118249327 619 4084526
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.0697091653377884 0.478805727912259 no 1783 0.472212573323027 606 689007
SGTC_160 3453-0671 289.699 µM -0.0703651142226649 0.478493796040501 no 1784 0.471951528607895 602 5322268
SGTC_2126 5251174 33.877 µM -0.0704214896223329 0.478466987728311 no 1785 0.471929093731152 578 790722
SGTC_3183 9108214 49.47 µM -0.0731826214378235 0.477154102523436 no 1786 0.470830397692832 590 4974831
SGTC_419 nsc-638432 893 µM -0.0738609689258814 0.476831593782754 no 1787 0.470560506632737 607 368090
SGTC_2090 5301565 104.445 µM -0.0761574161957428 0.475739900989767 no 1788 0.469646930603163 593 2056344
SGTC_724 3910-0327 137 µM -0.0765887028165102 0.475534894574449 no 1789 0.469475373200597 585 2885483
SGTC_3302 9125395 16.351 µM -0.0766700978093424 0.475496205261379 no 1790 0.469442996495296 593 17599668
SGTC_2502 avocadyne acetate 18.59 µM -0.0774417506553334 0.475129428643898 no 1791 0.46913606413396 584 3952079
SGTC_249 wiskostatin 11.211 µM -0.0800488854378075 0.473890381337362 no 1792 0.468099187864148 593 2775510 A n-wasp and actin depolymerizer.
SGTC_2130 NSC 7 2.4545 µM -0.0804617859308325 0.473694172204801 no 1793 0.467934994032991 583 21448
SGTC_2325 6158266 200 µM -0.0806748150567161 0.473592943866394 no 1794 0.467850283094522 584 3623240
SGTC_2541 muurolladie-3-one 83.07 µM -0.0810919165108987 0.473394748273162 no 1795 0.467684427103517 610 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1641 st009299 47.1 µM -0.0820097778180724 0.472958628086627 no 1796 0.467319469037527 586 4046054
SGTC_3217 9129673 49.47 µM -0.082155154685026 0.472889555483914 no 1797 0.467261667108264 602 17248312
SGTC_1279 0874-0590 65.2 µM -0.0837500291184528 0.472131840153893 no 1798 0.46662758967448 594 3523074
SGTC_192 3455-0609 60.9 µM -0.0838089496420592 0.472103849279405 no 1799 0.466604166135794 596 3769639
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.0845955819711312 0.471730163769111 no 1800 0.466291455777478 584 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.08498868392589 0.471543432077909 no 1801 0.466135193538878 601 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2708 st078559 56 µM -0.0857006196673378 0.471205263587988 no 1802 0.465852204759618 575 17250902
SGTC_1769 st044406 64.4 µM -0.0858683247321761 0.47112560692697 no 1803 0.465785545841163 587 670903
SGTC_855 0428-0020 25 µM -0.0864016052231247 0.470872316704101 no 1804 0.465573585460378 592 6812414
SGTC_1313 1220-0047 237 µM -0.0901837442516382 0.469076272464041 no 1805 0.464070600946337 583 3528706
SGTC_950 1165-0508 94.1 µM -0.0903192485304548 0.469011936290625 no 1806 0.464016762274435 593 6148369
SGTC_992 3909-8734 162 µM -0.0910219162943674 0.468678329175146 no 1807 0.463737588327944 614 4288319
SGTC_1824 st053723 68.6 µM -0.0918000606991977 0.468308913520737 no 1808 0.463428447918049 613 675225
SGTC_2607 solasodine 47.35 µM -0.0920385195426355 0.468195713206961 no 1809 0.46333371764543 594 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1240 0356-0016 42.1 µM -0.0924190513039572 0.468015073884877 no 1810 0.463182551726748 595 4305613
SGTC_886 0866-0150 153 µM -0.0926849317802139 0.467888863703515 no 1811 0.463076934087176 606 271463
SGTC_2712 st079126 47.7 µM -0.0927378348918307 0.467863751633809 no 1812 0.463055919308762 606 3152970
SGTC_1907 st060210 83.7 µM -0.0927709762037056 0.467848020168076 no 1813 0.46304275459074 613 688793
SGTC_2659 sanguinarine 24.21 µM -0.0933494839592327 0.467573423127449 no 1814 0.462812960579903 590 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_175 3793-3120 23.7 µM -0.0936099449821631 0.4674497965801 no 1815 0.462709504677165 609 5322297
SGTC_872 0588-0139 234 µM -0.0942876054113888 0.467128163120708 no 1816 0.462440347749889 584 2047100
SGTC_151 3013-0144 2.285 µM -0.0943139475888985 0.467115660940314 no 1817 0.462429885364192 614 906558 YHR107C CDC12
SGTC_299 1273-0059 1.44 µM -0.0950499676890877 0.466766353850444 no 1818 0.462137569034644 600 2848077
SGTC_2067 5224629 34.075 µM -0.0958233467224537 0.466399344201016 no 1819 0.461830437338446 601 2835000
SGTC_826 1683-5028 118 µM -0.0969695794586154 0.465855448201908 no 1820 0.461375276323285 608 722377
SGTC_2992 9074591 71.4286 µM -0.101045110683226 0.463922101606998 no 1821 0.459757325128327 580 17741321
SGTC_3187 9109394 49.47 µM -0.101078131557939 0.463906440612629 no 1822 0.459744218806845 585 17098090
SGTC_2794 7785382 27.27 µM -0.101221099716121 0.463838634952661 no 1823 0.459687473793667 595 2205081
SGTC_1757 st041620 31.8375 µM -0.101911036560902 0.463511432673787 no 1824 0.459413644833593 594 5289815
SGTC_1600 coumarin 106 71.1 µM -0.101956933051073 0.463489667154378 no 1825 0.4593954296621 629 100336 A hepatotoxic, DNA x-linker.
SGTC_2684 capsaicin 100 µM -0.103840235365244 0.462596642588354 no 1826 0.458648067921129 596 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2228 7354201 200 µM -0.104422214674757 0.46232071746866 no 1827 0.458417147144529 598 753451
SGTC_593 1203-0218 61.7 µM -0.104569265628152 0.462251001270273 no 1828 0.458358801720403 601 3666956
SGTC_391 gliotoxin 8.33 µM -0.104657391180167 0.462209221896372 no 1829 0.458323836564592 608 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_537 1334-0398 209 µM -0.104987145965025 0.462052892411655 no 1830 0.458193004191334 618 5846986
SGTC_2647 atorvastatin 60.16 µM -0.105548326780735 0.461786862429767 no 1831 0.45797036244323 608 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_3001 9076041 71.4286 µM -0.105788528897309 0.461672998885733 no 1832 0.457875069164811 611 16004211
SGTC_926 2268-1401 59.4 µM -0.106120767035264 0.461515512481032 no 1833 0.457743267235079 592 2931578
SGTC_679 0422-0091 41.4 µM -0.106241402988549 0.461458330524268 no 1834 0.457695410990397 590 627384 YHR062C RPP1
SGTC_227 fluconazole 33.516 µM -0.106417691771447 0.461374770321965 no 1835 0.457625478388968 609 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_3206 9114350 49.47 µM -0.106464834987289 0.461352424908529 no 1836 0.457606777207358 609 17087243
SGTC_3237 9133362 49.47 µM -0.107070378044425 0.461065414421131 no 1837 0.45736657347182 609 43845137
SGTC_222 nsc-310342 10.666 µM -0.109289944524929 0.460013576454732 no 1838 0.456486260963938 596 432556
SGTC_1967 st070177 51.4 µM -0.110418242683013 0.459478990169699 no 1839 0.456038843011175 607 5729214
SGTC_1557 sumaresinolic acid 42.3 µM -0.110610332073339 0.459387985722714 no 1840 0.455962676978361 593 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2907 7721985 69.9 µM -0.11091169119864 0.459245217834915 no 1841 0.455843187284587 606 3267881
SGTC_885 0865-0106 16.8 µM -0.110949939975428 0.459227097979039 no 1842 0.455828021828371 592 2793380
SGTC_3027 9089541 49.47 µM -0.111626949447898 0.458906387681619 no 1843 0.455559601496698 607 9943819
SGTC_2299 7976368 114.88 µM -0.112983024329833 0.458264073799774 no 1844 0.455022006826152 602 2979718
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.113696237609218 0.45792629920903 no 1845 0.454739297567447 608 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3336 9143619 71.43 µM -0.114423349155714 0.45758197374066 no 1846 0.454451102800251 604 45595730
SGTC_2768 sulfasalazine 50.2 µM -0.114475539170062 0.457557260251979 no 1847 0.454430417913817 633 5384001 An antioxidant and salicylic acid derivative.
SGTC_2381 9035592 200 µM -0.114820547065872 0.457393893118499 no 1848 0.45429368128227 629 4749657
SGTC_2614 arthonioic acid 13.39 µM -0.115978994563657 0.456845401261516 no 1849 0.453834594673779 617 6710684
SGTC_1905 st060207 84.5 µM -0.116138117559998 0.456770067457934 no 1850 0.453771539877119 586 1948547
SGTC_1574 spiramycin 23.7 µM -0.116428721131328 0.456632490649162 no 1851 0.453656387002845 595 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1786 berberine 21.6 µM -0.116498883248496 0.456599275455258 no 1852 0.453628585555506 626 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1089 terbinafine 2.25 µM -0.116577260566482 0.456562171491462 no 1853 0.453597529137704 612 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2488 5268135 45.7 µM -0.116634211266707 0.456535211164746 no 1854 0.453574963032673 612 1270356 YLR208W SEC13
SGTC_46 0329-0187a 2.197 µM -0.116751591191979 0.456479644417213 no 1855 0.453528452967331 608 46494817
SGTC_124 0136-0217 7.121 µM -0.117650309390326 0.456054226464834 no 1856 0.453172370296146 615 3976905
SGTC_2557 derrustone 83.84 µM -0.119050384844389 0.455391586191293 no 1857 0.452617719126023 650 629853 An antioxidant.
SGTC_1414 3917-0015 5.4 µM -0.119448945956452 0.455202974221046 no 1858 0.452459842787243 599 6618702
SGTC_2872 9044037 25.97 µM -0.119683849240006 0.45509181513921 no 1859 0.452366797412661 588 6465195
SGTC_1390 3413-2614 145 µM -0.120033889057808 0.454926178579636 no 1860 0.452228151221518 632 3421432
SGTC_2638 epoxomicin 18 µM -0.120560775831422 0.454676873977488 no 1861 0.452019469254121 617 9915668 A protesome inhibitor.
SGTC_3232 9132874 49.47 µM -0.120755723029205 0.454584636223869 no 1862 0.451942260642527 620 3784940
SGTC_2120 5538279 151.968 µM -0.121149522191193 0.454398320681378 no 1863 0.451786302488139 597 2058197
SGTC_1107 amlodipine 47 µM -0.121164996116979 0.454390999811797 no 1864 0.451780174427511 613 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2882 9058044 58.44 µM -0.121744455391653 0.454116862988815 no 1865 0.451550702383049 618 18076804
SGTC_304 1310-0298 97 µM -0.12268390144923 0.45367246624703 no 1866 0.45117870616824 598 1550234
SGTC_1466 k213-0079 57.5 µM -0.122827586182567 0.453604502540562 no 1867 0.451121814521337 610 3657981
SGTC_1116 jasmonic acid 1.58368 µM -0.123864469880467 0.453114090981657 no 1868 0.45071129259104 607 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1480 1070-0044 41.2 µM -0.124079701371246 0.453012302569865 no 1869 0.450626084953178 593 3124987
SGTC_3 0833-0587 95.581 µM -0.124873252642875 0.452637038843921 no 1870 0.450311946947869 594 5382644
SGTC_333 3486-0131 40.1 µM -0.125090852399369 0.452534145124005 no 1871 0.450225812570523 603 6744690
SGTC_812 4251-0442 148 µM -0.12534847654627 0.452412329684316 no 1872 0.450123838026912 631 5723007
SGTC_3230 9131665 49.47 µM -0.125519125156795 0.452331642370599 no 1873 0.450056292544838 605 15943720
SGTC_2912 7964298 10.93 µM -0.125788037637026 0.452204497217971 no 1874 0.449949855569732 602 2975850
SGTC_2291 7917025 104.35 µM -0.125971963998876 0.452117537377026 no 1875 0.449877058620493 603 2964612
SGTC_3165 9101544 49.47 µM -0.126076797529875 0.452067973420525 no 1876 0.449835566893115 614 5002184
SGTC_1372 2752-0194 270 µM -0.126339570483716 0.451943741003758 no 1877 0.449731567238612 599 823334
SGTC_1300 1094-0077 113 µM -0.126362995413515 0.451932666516753 no 1878 0.449722296343132 595 5532636
SGTC_1422 4031-0024 15.5 µM -0.126494205310885 0.451870635760974 no 1879 0.449670367847851 617 782427
SGTC_1665 st014639 11.4 µM -0.126798633826437 0.451726718746025 no 1880 0.449549888529688 600 981133 YIL048W NEO1
SGTC_1019 4262-0212 3.4 µM -0.127256939025892 0.451510069290192 no 1881 0.449368520411965 597 4677213
SGTC_2851 9015922 71.43 µM -0.128256552121234 0.451037583636146 no 1882 0.448972973722385 598 2996893
SGTC_1061 3448-9325 110 µM -0.128341263521258 0.450997546401988 no 1883 0.448939455764643 605 723482
SGTC_1268 0828-0275 2.46 µM -0.128981967291649 0.450694746108489 no 1884 0.448685958823171 625 745337
SGTC_1363 1636-0063 10.4 µM -0.131382336673942 0.449560574249657 no 1885 0.447736430415631 593 6072185
SGTC_1785 bathophenanthroline 24 µM -0.132270231662338 0.449141148731881 no 1886 0.447385276079954 604 72812 An iron chelator.
SGTC_9 0092-0002 10.449 µM -0.136007111090993 0.447376542810153 no 1887 0.44590782968369 608 759368
SGTC_609 0986-0026 86.3 µM -0.137498669410706 0.446672497194041 no 1888 0.445318322206465 618 2848610
SGTC_3093 9117344 49.47 µM -0.137614243279607 0.446617950983399 no 1889 0.445272649062761 603 24824913
SGTC_1685 st024049 53.0905 µM -0.138126622968349 0.446376140587844 no 1890 0.44507017267873 623 1941139
SGTC_2747 doxorubicin 7.63 µM -0.138762368631867 0.446076137082257 no 1891 0.444818965856119 589 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_265 mycophenolic acid 32.932 µM -0.139936137424195 0.445522325814916 no 1892 0.444355224328606 600 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1943 st076331 65.2 µM -0.140650370074398 0.445185386274678 no 1893 0.444073077078735 610 24208415
SGTC_1344 1488-0097 29.1 µM -0.140810373660182 0.445109909938624 no 1894 0.444009873863547 597 747966
SGTC_1340 1486-1359 257 µM -0.14154208985689 0.444764772711305 no 1895 0.443720855909737 624 4309068
SGTC_2677 mitomycin C 100 µM -0.141544944852031 0.444763426143838 no 1896 0.443719728283978 605 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2977 9011197 71.43 µM -0.141731337394587 0.444675514892967 no 1897 0.443646110569871 600 2704722
SGTC_2153 5569715 200 µM -0.141951684991415 0.44457159239538 no 1898 0.443559084455157 618 2054701
SGTC_2221 6807166 181.081 µM -0.144560414783965 0.443341529144859 no 1899 0.442528976637099 604 674925
SGTC_2464 5717415 7.67 µM -0.145979126001707 0.442672809513696 no 1900 0.441968933463231 608 5285744
SGTC_2924 9010168 62.78 µM -0.146306874603379 0.442518346026732 no 1901 0.441839569554552 625 2993929
SGTC_2802 7925815 54.55 µM -0.14665672315382 0.442353476774238 no 1902 0.441701489537488 607 1262923
SGTC_974 1326-0144 138 µM -0.146891623667277 0.442242783410737 no 1903 0.441608781774418 637 5411856
SGTC_1860 st056228 74.6 µM -0.147682808847665 0.441869982417217 no 1904 0.441296549703355 623 688679
SGTC_458 nppb 133 µM -0.14819058829522 0.441630747351235 no 1905 0.441096179631134 620 4549 A chloride channel blocker.
SGTC_123 0083-0120 66.675 µM -0.149115581094725 0.441195001285149 no 1906 0.440731215705324 610 16001701
SGTC_3231 9132313 49.47 µM -0.150300987749381 0.440636683454359 no 1907 0.440263576865821 634 4905967
SGTC_2520 obtusaquinone 4.71 µM -0.150850257665935 0.440378021290731 no 1908 0.440046919982911 605 5967872
SGTC_2115 tiliquinol 12.7705 µM -0.151788965287132 0.439936024091542 no 1909 0.439676692854931 641 71208 A bioactive hydroxyquinoline.
SGTC_164 4100-3994 89.624 µM -0.152285692900265 0.439702166588524 no 1910 0.439480804359638 607 4615967
SGTC_1433 4060-0023 7.6 µM -0.152884427521416 0.439420312537133 no 1911 0.439244708285645 607 3840627
SGTC_2469 5655019 90.81 µM -0.15337213506818 0.439190747117708 no 1912 0.439052408938301 626 2788239
SGTC_1699 st031318 29.054 µM -0.153744216147285 0.439015621175258 no 1913 0.438905709891192 641 5340658
SGTC_1740 st038286 13.222 µM -0.15380745467851 0.438985858129599 no 1914 0.438880777900402 617 716786
SGTC_2313 7726885 200 µM -0.154017485408439 0.438887010204477 no 1915 0.438797974362084 610 726423
SGTC_1807 st050092 58.9 µM -0.15531535158953 0.438276273035195 no 1916 0.43828635682731 649 5008496
SGTC_2814 7977482 42.97 µM -0.155927068160775 0.43798846830746 no 1917 0.438045254478437 603 6456762
SGTC_696 1560-0013 611 µM -0.157414841945827 0.43728862718895 no 1918 0.43745895854943 627 1650269
SGTC_1081 sertraline 6 µM -0.158785715840242 0.436643948773992 no 1919 0.43691885156678 615 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1149 3909-7961 23.3 µM -0.159709161611448 0.436209776308563 no 1920 0.436555091811864 602 735261
SGTC_1993 st073995 70.8 µM -0.160752812636672 0.435719179997323 no 1921 0.436144045913343 623 3098394
SGTC_3316 9136639 10.545 µM -0.161039735369928 0.435584321529616 no 1922 0.436031052377136 639 4903665
SGTC_1471 k673-0312 37 µM -0.16255423166406 0.43487260750725 no 1923 0.435434712704455 621 24099884
SGTC_1385 3091-4834 14.1 µM -0.163281978799946 0.434530688940976 no 1924 0.435148211156865 616 4072814
SGTC_3289 9119912 71.43 µM -0.163403580849686 0.434473561228644 no 1925 0.435100341833898 669 17014829
SGTC_1806 st050005 60.3 µM -0.164613944368039 0.433905016486897 no 1926 0.434623927467996 623 5194765
SGTC_1393 3470-5649 58.2 µM -0.165384723345653 0.433543029216177 no 1927 0.434320588551916 625 4108395
SGTC_1180 1193-0155 285 µM -0.166023616288542 0.433243022903438 no 1928 0.43406918248808 642 2921347
SGTC_1607 st000305 50.6 µM -0.166417489703952 0.433058090084626 no 1929 0.433914205537275 647 5457690
SGTC_3150 9097574 49.47 µM -0.167211879015317 0.432685150283729 no 1930 0.433601668953803 661 17217476
SGTC_3285 9112818 20.8695 µM -0.167700773404433 0.432455660139603 no 1931 0.433409343859535 615 17017947 YPR165W RHO1
SGTC_1660 st012960 28.1 µM -0.168088064280725 0.432273879502081 no 1932 0.433256999539588 638 24207266
SGTC_1325 1431-0015 227 µM -0.169439521157013 0.431639665988149 no 1933 0.432725469751695 621 1103340
SGTC_2829 7992743 58.44 µM -0.169840189346916 0.431451673660637 no 1934 0.432567909765855 608 16462845
SGTC_839 0122-0028 230 µM -0.169935128799388 0.431407130624572 no 1935 0.432530577055183 625 759448
SGTC_2980 9014342 25.29 µM -0.170026033128485 0.431364481577238 no 1936 0.432494831626484 625 2996599
SGTC_2262 9014885 67.46 µM -0.171777343818665 0.430542986265282 no 1937 0.431806288880735 628 6457424
SGTC_1054 3429-0080 167 µM -0.172617656150478 0.430148923579544 no 1938 0.431475986316717 668 1162877
SGTC_1415 3966-0071 78.1 µM -0.173438976700611 0.429763834268001 no 1939 0.431153195169097 642 2893185
SGTC_843 0310-0051 143 µM -0.175486750952761 0.428803994199719 no 1940 0.430348590225549 623 2065037
SGTC_2586 curcumin 80 µM -0.175636290162357 0.428733918069258 no 1941 0.430289845041729 640 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1749 st037932 54.2 µM -0.175954019986158 0.428585032964032 no 1942 0.430165032754629 646 594497
SGTC_521 r062-0005 13.8 µM -0.176656182341596 0.428256042589416 no 1943 0.429889230440652 615 2832033
SGTC_3334 9142812 21.919 µM -0.176751956127572 0.428211172704504 no 1944 0.429851614108678 630 45283678
SGTC_3109 9122853 49.47 µM -0.177188924834585 0.428006465261906 no 1945 0.429679997361846 655 1234709
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.179551336542276 0.426900079283525 no 1946 0.428752405737318 649 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1898 st060199 18.6 µM -0.180126824774891 0.426630648179338 no 1947 0.428526501950475 614 688866
SGTC_3145 9085516 49.47 µM -0.181128146003859 0.426161932976494 no 1948 0.428133496328111 612 25236195
SGTC_1338 1486-1223 76 µM -0.181466433583932 0.426003605197447 no 1949 0.428000738919024 639 3444526
SGTC_23 0213-0011 39.996 µM -0.182651844494411 0.425448894972608 no 1950 0.427535601261952 643 627608
SGTC_3240 9133527 49.47 µM -0.182741401261883 0.425406993076039 no 1951 0.427500464598219 671 17617455
SGTC_2128 5255449 168.493 µM -0.183314748671633 0.425138754784278 no 1952 0.42727553135797 624 736008
SGTC_375 3970-0961 9.27 µM -0.183541345828419 0.425032751758243 no 1953 0.42718664022982 619 2898222
SGTC_1856 st057054 55.7 µM -0.184606767176656 0.424534416309554 no 1954 0.426768738869738 665 1266018
SGTC_413 propylparaben 100 µM -0.185080954088388 0.424312660965975 no 1955 0.42658276997933 631 7175 A pharmaceutical preservative.
SGTC_272 doxorubicin 8.13 µM -0.18540594171174 0.424160693079091 no 1956 0.426455324202463 620 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2403 6032726 181.2 µM -0.18614330001191 0.423815937849146 no 1957 0.426166193375413 636 2881040
SGTC_2873 9040596 71.43 µM -0.186604961747514 0.423600115464925 no 1958 0.425985188086964 666 6463863
SGTC_92 0063-0024 660.874 µM -0.186949304380947 0.423439153541269 no 1959 0.425850190648706 615 3594437
SGTC_1243 0416-0003 5.65 µM -0.187433458425247 0.423212858811797 no 1960 0.42566039569846 648 2141977
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.188811509218989 0.422568893551372 no 1961 0.425120275520063 629 23665772 A membrane-active detergent.
SGTC_2097 5376186 200 µM -0.190009595218198 0.422009194176462 no 1962 0.424650805804847 629 742755
SGTC_541 4513-1321 94 µM -0.191632336890395 0.421251363417539 no 1963 0.424015105376018 614 747515
SGTC_2943 9068529 45.32 µM -0.192346543319244 0.420917916697636 no 1964 0.423735381345916 623 3270634
SGTC_1197 1601-0112 267 µM -0.193120713455919 0.420556538361528 no 1965 0.423432215506298 636 7350313
SGTC_2883 9059145 45.46 µM -0.193209162457539 0.42051525511249 no 1966 0.42339758166581 621 16476510
SGTC_528 3492-0019 172 µM -0.194122351289798 0.420089078743634 no 1967 0.42304004035649 601 2869262
SGTC_2651 TUB2.036 5 µM -0.194213230201824 0.420046671554267 no 1968 0.423004461950364 627 15992207 YFL037W TUB2
SGTC_3267 9137951 49.47 µM -0.194974325386234 0.419691555157118 no 1969 0.422706523625214 614 16643986
SGTC_1602 st001878 87.6 µM -0.195064513265219 0.419649479078407 no 1970 0.422671221604079 681 595405 YLR310C CDC25
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.195586537363479 0.419405953025987 no 1971 0.422466899196106 645 2374 Ca(2+)-ATPase inhibitor.
SGTC_3090 9117696 49.47 µM -0.196825599283905 0.418828050089988 no 1972 0.421982008813001 670 7923821
SGTC_3104 9120930 49.47 µM -0.196918348399954 0.418784798598109 no 1973 0.421945717429268 662 17014836
SGTC_2448 5185112 27.17 µM -0.1985825693167 0.418008893433032 no 1974 0.421294644860372 621 5718189
SGTC_1999 st074831 12.5 µM -0.199178467553472 0.417731146835038 no 1975 0.42106157117936 687 17112523
SGTC_1068 loratadine 26.9 µM -0.199624302384299 0.417523371221811 no 1976 0.42088720988486 650 3957 A H1 histamine antagonist.
SGTC_376 3970-0862 59.1 µM -0.200407001194905 0.417158660192246 no 1977 0.420581142199029 674 3135186
SGTC_2304 7443016 91.4 µM -0.200461298885877 0.417133361954705 no 1978 0.420559911329235 641 939854
SGTC_1522 st012842 45.6 µM -0.200469772240257 0.417129414102636 no 1979 0.420556598194761 644 3491067 YOR116C RPO31
SGTC_1780 st038448 24.544 µM -0.202365241503139 0.416246499675189 no 1980 0.419815599742839 678 728868 YDL195W SEC31
SGTC_733 4069-0007 56.1 µM -0.202438506960618 0.416212380889707 no 1981 0.419786963662975 624 5717425 YNL287W SEC21
SGTC_444 curcumin 90.4 µM -0.20266969527104 0.416104723594299 no 1982 0.419696605626821 644 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_415 dibenzyl ketone 100 µM -0.203688003794078 0.415630603620958 no 1983 0.419298658630264 661 7593
SGTC_54 0159-0055 9 µM -0.203874706142129 0.415543689128821 no 1984 0.419225705756183 703 3319099
SGTC_339 3091-4833 71.4 µM -0.204118888715722 0.415430022427498 no 1985 0.419130297004053 628 3240077
SGTC_535 2293-4129 48.2 µM -0.204742669352833 0.415139685424833 no 1986 0.418886590598949 673 396118 YIL048W NEO1
SGTC_2719 novobiocin 32.65 µM -0.206085868416076 0.414514654581516 no 1987 0.418361918605887 646 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_402 epigallocatechin gallate 10 µM -0.206497995337129 0.414322922863647 no 1988 0.418200965244506 650 65064 An antioxidant.
SGTC_2243 6634756 200 µM -0.207614031199305 0.413803817777637 no 1989 0.41776517388403 624 885676
SGTC_2627 acetyl isogambogic acid 100 µM -0.209040084804942 0.413140732468587 no 1990 0.41720847332684 658 6857789 A caspase activator and apoptosis inducer.
SGTC_2204 7233102 200 µM -0.209221896588278 0.413056211529511 no 1991 0.417137509832945 654 2172480
SGTC_1559 coumarin 343 70.1 µM -0.209580673307349 0.412889434687275 no 1992 0.416997482553732 659 108770 A hepatotoxic, DNA x-linker.
SGTC_3143 9086658 49.47 µM -0.209820500220316 0.412777960256784 no 1993 0.41690388616848 645 25236626
SGTC_1821 st053465 65.6 µM -0.210474689161821 0.412473921163262 no 1994 0.416648602167414 658 675086
SGTC_747 3448-8087 38.7 µM -0.211133058685154 0.412167992130075 no 1995 0.416391722264403 672 5168703
SGTC_290 2043-6722 48.1 µM -0.211134039433345 0.412167536438921 no 1996 0.41639133962673 641 773758 YLR208W SEC13
SGTC_2364 9055074 200 µM -0.211584929062826 0.41195804932762 no 1997 0.416215434001933 657 6470630
SGTC_1678 st019265 80.2 µM -0.211626820443423 0.411938587512928 no 1998 0.416199091764077 673 5367020
SGTC_260 nsc-65238 3.989 µM -0.21249542897432 0.41153509995616 no 1999 0.415860271755594 635 3246252
SGTC_2192 5915882 198.485 µM -0.213295619701009 0.411163476721977 no 2000 0.41554819496014 642 2876149
SGTC_824 1304-0008 100 µM -0.213349310888988 0.41113854440034 no 2001 0.415527257139567 638 768245
SGTC_503 tyrphostin 8 294 µM -0.213416226181102 0.411107471766784 no 2002 0.415501162683348 684 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1655 st012546 55.1 µM -0.213524294381192 0.411057290639772 no 2003 0.415459020922193 658 720985 YLR208W SEC13
SGTC_2347 9049783 174.81 µM -0.213528299213345 0.411055431036586 no 2004 0.415457459235583 687 6467988 YPL169C MEX67
SGTC_2589 lobaric acid 100 µM -0.213677989255742 0.41098592541775 no 2005 0.415399088475179 647 73157 A novel microtubule depolymerizer.
SGTC_671 0560-0003 407 µM -0.214132599272541 0.41077485336255 no 2006 0.415221827396495 657 3238678
SGTC_1975 st070967 30.8 µM -0.214249917067505 0.410720387772721 no 2007 0.415176085759935 640 261391
SGTC_2481 5478948 45.16 µM -0.214500913445521 0.410603866767739 no 2008 0.415078227357202 638 77792
SGTC_1298 1079-1278 263 µM -0.215186772364839 0.410285508131517 no 2009 0.414810851744408 675 2840950
SGTC_41 0478-0632 82.643 µM -0.217310756114302 0.409299983629436 no 2010 0.413983087607484 659 3750424
SGTC_1410 3909-8106 77.9 µM -0.217725825884958 0.409107458759805 no 2011 0.413821370107674 644 1039210
SGTC_984 1492-0255 2.91 µM -0.217878020923002 0.409036870504921 no 2012 0.413762076264812 669 1585198
SGTC_510 ag-490 170 µM -0.218574831325313 0.408713726645147 no 2013 0.413490630213088 652 5328779
SGTC_2409 alverine citrate 63.97 µM -0.21953737446329 0.408267452071882 no 2014 0.413115734636121 638 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2915 7971052 15.16 µM -0.219779679101509 0.408155128398155 no 2015 0.413021373216385 633 5741558
SGTC_3210 9128157 49.47 µM -0.220043962892494 0.408032624588385 no 2016 0.412918458118992 679 17590849
SGTC_3121 9125696 49.47 µM -0.220297114769195 0.40791528919863 no 2017 0.412819883526777 647 1235365
SGTC_902 1120-0002 2.07 µM -0.22075545174861 0.407702871941168 no 2018 0.412641426073797 666 3280475
SGTC_740 k014-0057 261 µM -0.220967508501028 0.40760460296014 no 2019 0.41255886605683 670 4012779
SGTC_1411 3909-8223 150 µM -0.221356491300196 0.407424359995684 no 2020 0.412407433513043 652 X1411
SGTC_2570 licareol 100 µM -0.221392087524679 0.407407866750919 no 2021 0.412393576412759 674 443158
SGTC_663 1486-0733 13.9 µM -0.221945399806021 0.407151514761536 no 2022 0.412178193919722 658 722445 YPR165W RHO1
SGTC_519 k048-0011 62.8 µM -0.222372812793236 0.406953519681331 no 2023 0.412011837123883 642 6836379
SGTC_2348 9022543 33.42 µM -0.22237915118902 0.406950583657397 no 2024 0.412009370225531 661 3162678 YDL140C RPO21
SGTC_1523 st012844 44.7 µM -0.223142462412638 0.406597046663952 no 2025 0.411712315584633 668 4274103
SGTC_699 0375-0592 111 µM -0.22343564856557 0.406461274103921 no 2026 0.411598230993152 622 762578
SGTC_1997 st073024 93.8 µM -0.224006866496144 0.406196779185606 no 2027 0.411375980152925 648 686268
SGTC_3134 9127454 49.47 µM -0.224449456048031 0.405991873362408 no 2028 0.411203795899204 646 24262820
SGTC_2771 fluoxetine 41.05 µM -0.226898420089342 0.404858542609728 no 2029 0.410251365302205 662 3386 A selective serotonin reuptake inhibitor.
SGTC_860 0443-0016 25.1 µM -0.22742812753556 0.40461350936719 no 2030 0.410045425326738 649 5337942
SGTC_2769 toremifene 3.73 µM -0.228952300093518 0.40390866322386 no 2031 0.409452995194939 642 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3051 9093778 49.47 µM -0.22993271029961 0.403455442005803 no 2032 0.409072029032385 660 17217378
SGTC_2415 st077333 57.7 µM -0.230350279999879 0.403262448409598 no 2033 0.40890979654997 615 2766255
SGTC_2062 5245942 200 µM -0.231250623709348 0.402846405117567 no 2034 0.408560051800792 641 1376160
SGTC_1077 5-fluorocytosine 377 nM -0.232247224435835 0.402386010311037 no 2035 0.408173000261533 673 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_596 1155-0152 116 µM -0.232380136450321 0.402324619808735 no 2036 0.408121387755551 640 280313
SGTC_664 1222-0054 14.9 µM -0.232794858131239 0.402133080215521 no 2037 0.407960352932325 640 6813991
SGTC_561 1550-0330 72.9 µM -0.233447746895689 0.401831590566821 no 2038 0.407706870264672 670 6812934
SGTC_2734 clemastine 41.6 µM -0.233626144704916 0.4017492205419 no 2039 0.407637614412253 667 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1122 capsaicin 818.572 nM -0.233807998403277 0.401665259352402 no 2040 0.407567019919199 680 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2922 7999257 32.47 µM -0.233907126910154 0.401619493993405 no 2041 0.407528540103192 632 2988377
SGTC_2893 9048488 25.97 µM -0.233969947589817 0.401590491824288 no 2042 0.407504154762504 636 6467338
SGTC_154 3389-1638 511.116 µM -0.234293033980804 0.401441342402669 no 2043 0.407378746760623 709 5238686
SGTC_1700 st030840 7.9285 µM -0.23430022935075 0.401438020899461 no 2044 0.407375953940821 640 5499307
SGTC_2387 9077560 195.08 µM -0.234756547247457 0.401227391476937 no 2045 0.407198847770572 633 5303272
SGTC_1166 k206-0078 225 µM -0.234910763152985 0.401156214239106 no 2046 0.407138997757672 646 5404595
SGTC_963 1269-2853 151 µM -0.234921884273346 0.401151081493075 no 2047 0.407134681819755 632 3668223
SGTC_1135 dihydrocapsaicin 536.708 nM -0.235661135549724 0.400809932130504 no 2048 0.406847814937494 675 107982 A Capsaicinoid.
SGTC_3283 9109332 35.8195 µM -0.235739496946626 0.400773774375635 no 2049 0.406817409679109 651 17027281
SGTC_278 4092-0821 23.9 µM -0.236970690006177 0.400205785313622 no 2050 0.406339764340612 677 877900
SGTC_2150 5556613 200 µM -0.239558673108386 0.399012554545997 no 2051 0.405336202992365 637 743190
SGTC_2854 9024559 71.43 µM -0.241672351742358 0.398038708483348 no 2052 0.404517027353691 685 3163529
SGTC_1498 4478-3555 97.6 µM -0.241834716015181 0.397963927734294 no 2053 0.404454118841168 656 3437919
SGTC_3212 9128307 49.47 µM -0.242002266650866 0.397886762211629 no 2054 0.404389203446883 692 27243542
SGTC_1346 1488-2224 62.4 µM -0.242284843911235 0.397756630174528 no 2055 0.404279728391979 662 3722427
SGTC_881 0833-0569 170 µM -0.243156020569798 0.397355508920634 no 2056 0.403942267505427 637 5418700
SGTC_367 0335-0881 7.1 µM -0.243345207131246 0.397268414911515 no 2057 0.403868993225421 687 23828853
SGTC_47 0149-0135 24.25 µM -0.243453784824798 0.397218432349619 no 2058 0.403826941273881 647 5239155
SGTC_1409 3909-8004 61.9 µM -0.244329268964013 0.396815474477791 no 2059 0.403487908448198 639 2119279
SGTC_3191 9110352 49.47 µM -0.24455722795327 0.396710570167543 no 2060 0.403399642803689 647 17122424
SGTC_648 0375-0473 33.3 µM -0.245223289365861 0.396404098622376 no 2061 0.403141772255599 664 1713139
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.246558721940632 0.395789825604372 no 2062 0.40262487674442 667 364106
SGTC_1275 0867-0008 21.1 µM -0.246665878152115 0.395740547024094 no 2063 0.402583407985638 669 3422836
SGTC_140 0062-0056 502.533 µM -0.247040084973577 0.39556847132824 no 2064 0.402438600973204 659 3758964
SGTC_1022 4477-0945 21.3 µM -0.247085951503741 0.395547381409924 no 2065 0.402420852898193 643 4648966
SGTC_1805 st050013 60.3 µM -0.247497920786304 0.395357967271475 no 2066 0.402261450215047 666 4037144
SGTC_2145 5634607 200 µM -0.248529736842042 0.394883670213974 no 2067 0.401862282492785 677 308662
SGTC_3193 9111931 49.47 µM -0.249241163562276 0.39455673785844 no 2068 0.401587119979029 666 17087244
SGTC_2077 5212015 200 µM -0.250269056643766 0.394084506272965 no 2069 0.401189642191429 655 780900
SGTC_3280 9140961 49.47 µM -0.253129681043499 0.392771108184779 no 2070 0.400084001714839 661 4901226
SGTC_2072 5231554 129 µM -0.253396713017538 0.392648567860164 no 2071 0.399980833713057 677 789545
SGTC_1625 st003711 30.1 µM -0.254001611537263 0.392371020768829 no 2072 0.39974715654759 652 24207034 YER133W GLC7
SGTC_2328 6201408 200 µM -0.254346093975518 0.392212985488396 no 2073 0.399614096248762 692 2890418
SGTC_394 menadione 8.33 µM -0.256195807512507 0.391364712736216 no 2074 0.39889982287492 675 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_48 0382-0018 55 µM -0.256502284581493 0.391224213088084 no 2075 0.398781508298005 656 762596
SGTC_1949 st076024 69.1 µM -0.256961668966302 0.391013642044091 no 2076 0.398604181720369 640 2921930
SGTC_1188 1403-0014 4.57 µM -0.25734061942912 0.39083996406939 no 2077 0.398457919126066 664 9614867
SGTC_2666 tannic acid 100 µM -0.257405050878035 0.390810436454675 no 2078 0.398433052093581 661 16134267 A thiamine antagonist.
SGTC_704 1310-0270 142 µM -0.257614848932803 0.390714294661994 no 2079 0.398352084321334 689 5718033
SGTC_2506 ethyl hematommate 54.16 µM -0.257928450415231 0.39057059649877 no 2080 0.398231063650193 660 3940691 An allergen.
SGTC_1910 st062352 60.4 µM -0.259005736533957 0.390077077475332 no 2081 0.397815407188007 646 2245730
SGTC_2289 7946404 165.07 µM -0.259709639763304 0.389754705716941 no 2082 0.397543878138299 659 1246120 YPR165W RHO1
SGTC_2865 9030313 51.95 µM -0.259960792905881 0.389639701601067 no 2083 0.397447008399465 645 42562754
SGTC_1388 3346-4487 254 µM -0.261019780752437 0.389154892840896 no 2084 0.397038626527376 687 3345614
SGTC_1617 st002906 78 µM -0.26334114550016 0.388092767531531 no 2085 0.39614382449126 682 5150859
SGTC_827 3253-0474 693 µM -0.263727749905598 0.387915960251154 no 2086 0.395994855492768 677 5402065
SGTC_469 w7 172 µM -0.264259928917663 0.387672614785976 no 2087 0.395789817559207 653 45115570 A P450 inhibitor.
SGTC_1177 0983-0204 23.6 µM -0.264771206009825 0.387438868531952 no 2088 0.395592859873578 644 766818
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.265433180764871 0.387136286764187 no 2089 0.39533788900846 651 6312947
SGTC_2561 acetosyringone 100 µM -0.265516314230703 0.387098292165019 no 2090 0.395305871900486 663 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3054 9094397 49.47 µM -0.265540515845989 0.387087231471663 no 2091 0.39529655128957 683 2598354
SGTC_2298 7976326 193.81 µM -0.265956526075967 0.386897119593562 no 2092 0.39513634533987 669 2235818
SGTC_2927 9011802 47.9 µM -0.266667107054622 0.386572455056763 no 2093 0.394862740911645 673 43912568
SGTC_1276 0871-0068 94.2 µM -0.266910863505764 0.386461100978088 no 2094 0.394768896064255 653 3414906
SGTC_3275 9138069 49.47 µM -0.267302889435061 0.386282033284684 no 2095 0.394617981118814 652 17617007
SGTC_3033 9090887 49.47 µM -0.267757963616964 0.386074197093588 no 2096 0.394442814848832 654 19325384
SGTC_2225 6654152 15.4 µM -0.267956780627124 0.385983405957072 no 2097 0.394366293288608 685 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2921 7974240 10.71 µM -0.268389904733814 0.385785638520879 no 2098 0.394199604706102 695 2979074 YDR527W RBA50
SGTC_1822 st052468 42 µM -0.269361794445602 0.385341975122292 no 2099 0.393825641784716 657 2873678
SGTC_342 k048-0088 23.3 µM -0.269817553325215 0.385133974821274 no 2100 0.393650308953632 644 6820570
SGTC_2472 5377652 49.4 µM -0.269905730968293 0.385093735915992 no 2101 0.393616389040004 694 1610903
SGTC_2329 6138490 200 µM -0.270235659770136 0.384943187486338 no 2102 0.393489480172327 701 720019
SGTC_2522 biochanin a 4.94 µM -0.270346098843163 0.384892797368826 no 2103 0.39344700172268 692 5280373 A possible chelator.
SGTC_930 2810-3379 265 µM -0.270557958445305 0.384796137474075 no 2104 0.393365517198374 709 1015764
SGTC_2037 5169046 200 µM -0.270975038138696 0.384605867856389 no 2105 0.393205115461051 671 5718022
SGTC_2553 4-methylesculetin 85.09 µM -0.27123425104505 0.384487630258776 no 2106 0.393105435730059 675 5319502
SGTC_1649 st011737 51.3 µM -0.271716241565096 0.384267803263418 no 2107 0.392920106011901 654 1761035
SGTC_35 0133-0054 64.071 µM -0.272075635804936 0.38410391439151 no 2108 0.392781931466438 687 99677
SGTC_3115 9123671 49.47 µM -0.272104734160624 0.384090646034886 no 2109 0.392770744754952 659 3286988
SGTC_2444 5485484 36.41 µM -0.272179275958675 0.384056656859132 no 2110 0.392742087952529 706 6790631
SGTC_1912 st060209 90.8 µM -0.272633092925795 0.383849747042196 no 2111 0.392567635390331 705 688787
SGTC_3092 9117248 49.47 µM -0.273236933809079 0.383574487817224 no 2112 0.39233554534636 667 17141857
SGTC_3112 9123419 49.47 µM -0.273952294788501 0.383248468490251 no 2113 0.392060641407832 679 17015854
SGTC_2443 5493264 126.67 µM -0.273960945796182 0.383244526376815 no 2114 0.392057317267277 691 5340055
SGTC_1027 k015-0025 8.67 µM -0.274336922902009 0.383073211847388 no 2115 0.391912856076575 651 3598955
SGTC_3335 9143315 29.6265 µM -0.27446771263393 0.383013622669995 no 2116 0.391862606401339 658 4899691
SGTC_1111 tnp00062 510.699 nM -0.274853043222208 0.382838078099418 no 2117 0.391714572111332 659 676306
SGTC_314 1671-0008 2.74 µM -0.275527196178459 0.382531012985362 no 2118 0.391455617274449 694 3913060
SGTC_1521 st012942 49.4 µM -0.276208338899933 0.382220839143673 no 2119 0.391194026383914 661 24207259
SGTC_1644 st010134 20.9 µM -0.278654416950425 0.381107586078868 no 2120 0.390255023662761 694 3818134
SGTC_2276 7947513 42.08 µM -0.279014492201927 0.380943792315067 no 2121 0.390116851539657 696 2105100
SGTC_1635 st007035 42.4 µM -0.279952073836798 0.380517398216384 no 2122 0.389757137345315 684 3716403
SGTC_262 fenpropimorph 62.5 µM -0.280456822337373 0.38028790836137 no 2123 0.389563523734298 676 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3043 9092303 49.47 µM -0.282376360040044 0.379415553341591 no 2124 0.388827469846843 679 25236084
SGTC_322 k048-0136 19.3 µM -0.282589504583871 0.379318725226012 no 2125 0.388745763334706 658 6823282
SGTC_1001 4048-4355 44.4 µM -0.284652818446729 0.378381787307212 no 2126 0.387955070582609 705 21824233
SGTC_1515 3460-0031 42.1 µM -0.28493103178647 0.378255506922573 no 2127 0.387848490519174 664 2876596
SGTC_2105 5350118 200 µM -0.2858985477155 0.377816455022626 no 2128 0.387477913049155 670 2133313
SGTC_2 0422-0095 29 µM -0.286152760837836 0.377701121055753 no 2129 0.387380561455078 660 6790840
SGTC_2109 5483026 200 µM -0.288346907427865 0.376706112721129 no 2130 0.386540602101724 688 759335
SGTC_332 4112-0506 40.9 µM -0.289643172749541 0.376118662497686 no 2131 0.38604461748305 667 2790355
SGTC_1560 lithocholic acid 53.1 µM -0.289839883815129 0.37602954069657 no 2132 0.385969366996552 660 9903 A bile acid which acts as a detergent.
SGTC_1320 1313-0481 95.3 µM -0.290063058650097 0.375928437240915 no 2133 0.385883998169218 692 6813365 YLR208W SEC13
SGTC_176 1486-1328 72.834 µM -0.29141085548066 0.37531803478518 no 2134 0.385368556589641 659 22310231
SGTC_3300 9124615 50.48 µM -0.29198263434674 0.375059176565846 no 2135 0.385149950752514 686 24824903
SGTC_3087 9117406 49.47 µM -0.292967654075484 0.374613366158093 no 2136 0.384773437876841 661 42546093
SGTC_379 3970-0972 5.9 µM -0.293528876646257 0.374359437131652 no 2137 0.384558965328929 666 2898042 YBL034C STU1
SGTC_730 1436-0052 41.2 µM -0.294001097124894 0.374145819923498 no 2138 0.384378532509525 648 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2165 5727197 32.143 µM -0.294875886879517 0.373750195579182 no 2139 0.384044346416707 684 1361712
SGTC_763 3453-1109 128 µM -0.295039693560307 0.373676128651054 no 2140 0.383981778766567 698 1560353
SGTC_1709 st033179 39.1045 µM -0.295689129907959 0.373382525056681 no 2141 0.383733749633297 673 573381
SGTC_1839 st053978 48 µM -0.296077830227011 0.373206832724907 no 2142 0.383585322136369 667 3788398
SGTC_2742 clothiapine 36.27 µM -0.297068953176747 0.372758965069797 no 2143 0.383206933375847 684 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3120 9124077 49.47 µM -0.297365126540545 0.372625163886106 no 2144 0.383093882556036 682 18774327 YGL155W CDC43
SGTC_1394 3474-0001 65.7 µM -0.297790653359433 0.372432952060738 no 2145 0.382931474321004 661 5017666 YIL048W NEO1
SGTC_1378 2093-0007 380 nM -0.300376797422109 0.371265467392191 no 2146 0.381944879990657 690 3618014
SGTC_1163 k060-0048 49.9 µM -0.30174940370216 0.370646300338373 no 2147 0.381421551944934 662 6809982
SGTC_2191 5911152 200 µM -0.306181033007403 0.368649536084721 no 2148 0.379733406422306 677 2875902
SGTC_2017 5132927 60.65 µM -0.306270658201594 0.368609189913196 no 2149 0.379699288910409 691 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2529 gangaleoidin 93.61 µM -0.306467637062213 0.368520521913498 no 2150 0.379624308502277 673 4565183
SGTC_781 4335-2806 94.4 µM -0.310127645568368 0.366874284961471 no 2151 0.378231944929192 716 845254
SGTC_2783 7738165 71.43 µM -0.311236513784711 0.366376007852588 no 2152 0.377810413267043 666 17201110
SGTC_3133 9127736 49.47 µM -0.312244449363148 0.365923280813621 no 2153 0.377427376914106 685 27243420
SGTC_102 gallobenzophenone 83.616 µM -0.312471013384118 0.365821542380554 no 2154 0.377341294482264 681 70837
SGTC_523 1934-0222 13.7 µM -0.312527497906815 0.365796179509874 no 2155 0.377319834278326 705 1361595
SGTC_3253 9135987 49.47 µM -0.313373569775396 0.36541634372329 no 2156 0.376998430975824 692 4182430
SGTC_2080 5212524 12.4 µM -0.313901734809372 0.365179296010927 no 2157 0.376797836373589 686 260183
SGTC_2698 st077697 67.5 µM -0.314072100179613 0.365102844677638 no 2158 0.37673313949597 670 3154499
SGTC_2956 9076196 2.52 µM -0.31462480943132 0.364854853738508 no 2159 0.376523269960578 703 16423868
SGTC_1775 st081588 35.1725 µM -0.315035050089022 0.364670822499654 no 2160 0.376367520845551 699 1426443 YGL099W LSG1
SGTC_1468 k284-1086 134 µM -0.315301704696988 0.364551219728219 no 2161 0.3762662954035 685 15996457
SGTC_2560 caryophyllene 100 µM -0.315609964839682 0.364412972028915 no 2162 0.376149286583449 672 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_3258 9138477 49.47 µM -0.317045617047547 0.363769347086892 no 2163 0.375604494469804 662 4970355
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.317433458507634 0.363595537644291 no 2164 0.375457361365714 675 4330530
SGTC_791 1348-1292 225 µM -0.317603315927336 0.363519425626516 no 2165 0.375392929270612 720 5437054
SGTC_2531 methyl deoxycholate 70.07 µM -0.319226499839482 0.362792359447684 no 2166 0.374777381707239 716 16667744 Haematoxylin.
SGTC_2703 st077852 53.4 µM -0.321176110300801 0.361919731992792 no 2167 0.374038467548925 716 6281836
SGTC_1696 st025591 34.7925 µM -0.321350782928835 0.36184158510296 no 2168 0.373972288105687 676 2787147
SGTC_2822 7994718 71.43 µM -0.323276652938624 0.36098035153655 no 2169 0.373242866893471 701 1018011
SGTC_67 0335-0847 266 µM -0.323363417791869 0.36094156754154 no 2170 0.373210015467024 740 4552207 YOR254C SEC63
SGTC_1259 0671-0132 43 µM -0.324178814756891 0.360577154011899 no 2171 0.372901330064816 685 X1259
SGTC_139 0099-0334 718.624 µM -0.324623560842767 0.360378443428563 no 2172 0.372732996600306 688 97690
SGTC_1118 chelidonine 707.474 nM -0.326495622041597 0.359542428732538 no 2173 0.372024700547025 711 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2580 diallyl disulphide 81.36 µM -0.328959942033523 0.358442951058877 no 2174 0.371092983030905 640 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2396 5342950 42.78 µM -0.329828125850504 0.358055882151025 no 2175 0.370764917070503 690 1886677
SGTC_2224 6650123 117.647 µM -0.329949116607484 0.358001951504898 no 2176 0.370719205000854 694 2908370
SGTC_143 4032-1194 15.74 µM -0.329956802694242 0.357998525589935 no 2177 0.370716301147003 685 1806963
SGTC_1558 st069300 45.6 µM -0.330266358893718 0.35786055679364 no 2178 0.370599354912795 704 24208000
SGTC_2775 cyproheptadine 69.59 µM -0.331964544975515 0.357104008187373 no 2179 0.369958015649876 692 2913 A selective serotonin reuptake inhibitor.
SGTC_2124 5246320 200 µM -0.332331564771831 0.356940573107471 no 2180 0.36981945389856 697 579342
SGTC_1381 2324-0066 62.1 µM -0.333052343590294 0.356619684437922 no 2181 0.369547385962764 729 10885928
SGTC_1707 st032323 6.317 µM -0.333080016465332 0.356607366574032 no 2182 0.369536941754208 699 3132057 YMR211W DML1
SGTC_2032 5185112 25.99 µM -0.333486926470047 0.356426258393672 no 2183 0.36938337819208 680 5718189
SGTC_1554 st069299 38.7 µM -0.333506064732778 0.356417741100742 no 2184 0.369376156125615 680 24207999
SGTC_2108 5365811 200 µM -0.334096012800381 0.356155225745855 no 2185 0.369153554353636 672 780283
SGTC_1361 1608-0041 5.61 µM -0.334098167972712 0.3561542668612 no 2186 0.369152741235017 686 X1361
SGTC_141 0443-0274 32.331 µM -0.334179956045255 0.356117878180101 no 2187 0.36912188408685 697 1627241
SGTC_3216 9129716 49.47 µM -0.334497915507762 0.355976425928273 no 2188 0.369001931794579 674 8056934
SGTC_3146 9095609 49.47 µM -0.335221210335433 0.355654723921567 no 2189 0.368729111611857 680 17173999
SGTC_2584 androsterone 48.74 µM -0.335311701043569 0.355614483327941 no 2190 0.368694983998201 702 2754130 A steroid.
SGTC_995 3931-2021 34.6 µM -0.335363758508705 0.355591334461448 no 2191 0.368675351544904 699 730143
SGTC_1710 st031758 61.5 µM -0.335584976735946 0.355492969282158 no 2192 0.368591927247126 706 5394341
SGTC_3234 9132280 49.47 µM -0.3362768236281 0.355185400158794 no 2193 0.368331062688209 685 17612295
SGTC_1887 st057648 70.8 µM -0.336360711903736 0.355148112992306 no 2194 0.368299436289584 698 688672
SGTC_149 3970-0822 46.1 µM -0.337899624900749 0.354464334096352 no 2195 0.367719415118818 687 3114250 YBL034C STU1
SGTC_1653 st012112 65 µM -0.338082688154156 0.35438302550998 no 2196 0.367650438044387 700 720429
SGTC_780 0109-0199 192 µM -0.338404113732638 0.354240278566789 no 2197 0.367529337251423 725 610414
SGTC_682 0kpi-0099 17 µM -0.338637608109988 0.35413659521403 no 2198 0.367441373811292 706 1714895 YML126C ERG13
SGTC_1237 0330-0133 46.1 µM -0.339245608000056 0.353866663161473 no 2199 0.367212356992014 726 X1237 YHR072W ERG7
SGTC_584 0986-0246 15.4 µM -0.339644175738304 0.353689751972289 no 2200 0.367062253123613 719 53315 YDR232W HEM1
SGTC_2159 5658611 73.75 µM -0.340437494479872 0.35333771777537 no 2201 0.366763543290707 709 793844
SGTC_1923 st058458 19.1 µM -0.340789251489134 0.353181666166937 no 2202 0.366631121349358 730 3534982
SGTC_3105 9121040 49.47 µM -0.340949589850294 0.353110542698165 no 2203 0.36657076586469 668 41448907
SGTC_570 0987-0065 62.6 µM -0.341367603052599 0.352925143025051 no 2204 0.366413430456751 668 3104428
SGTC_914 3820-6779 408 µM -0.341467269554285 0.352880943505464 no 2205 0.366375920434289 681 2893481
SGTC_2326 6164455 177.58 µM -0.341566295515105 0.352837030015466 no 2206 0.366338652747088 697 2888790
SGTC_2827 7993847 71.43 µM -0.341843124789183 0.352714279280596 no 2207 0.366234476787705 704 2985692
SGTC_594 1487-1584 10.8 µM -0.341917962722306 0.352681097520341 no 2208 0.366206315586206 723 5013332
SGTC_2676 harmalol 100 µM -0.342122555313229 0.352590390657018 no 2209 0.366129331927338 677 5459187 A monoamine oxidase inhibitor
SGTC_496 calpeptin 138 µM -0.343779063331516 0.351856280888308 no 2210 0.365506223341099 687 73364 A calpain inhibitor.
SGTC_3229 9132204 49.47 µM -0.344474878566823 0.351548082955113 no 2211 0.365244592653112 685 17682924
SGTC_261 5-fluorouridine 15.376 µM -0.344681109819471 0.351456755534492 no 2212 0.365167060510557 685 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_330 1488-0319 80.1 µM -0.345235993098518 0.351211073681495 no 2213 0.364958480849021 680 6846614
SGTC_1192 1488-0095 21.4 µM -0.347334075265918 0.350282682950793 no 2214 0.364170177011818 718 915875
SGTC_2278 7948257 134.34 µM -0.347600900948912 0.350164677892445 no 2215 0.364069964784628 715 1247028
SGTC_476 mead acid 10 µM -0.347810394268029 0.350072038509287 no 2216 0.363991291494788 695 5312531 An omega 9 fatty acid.
SGTC_3239 9133757 49.47 µM -0.34787995962277 0.350041278205039 no 2217 0.36396516813305 710 17036923
SGTC_551 k048-0028 34.9 µM -0.348023610525128 0.349977761978419 no 2218 0.363911225975784 733 6836383
SGTC_2431 5490079 200 µM -0.348529217980458 0.349754237588141 no 2219 0.363721387455926 748 5722345
SGTC_1446 4239-0190 62 µM -0.348894323223591 0.349592860299264 no 2220 0.363584323566704 710 1340085
SGTC_59 0330-0160 1.33 µM -0.349466721547508 0.349339913741064 no 2221 0.36336947508236 700 4293482
SGTC_1963 st076565 50.3 µM -0.349543065415821 0.349306181940922 no 2222 0.363340822821604 697 4914280
SGTC_2322 7413319 38.22 µM -0.349575024661108 0.349292061410776 no 2223 0.363328828573502 703 1840400
SGTC_2661 dactinomycin 12.96 µM -0.349802238078611 0.349191677885858 no 2224 0.36324355964417 686 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1730 st033808 45.1 µM -0.349884909757996 0.349155155923426 no 2225 0.363212536196444 703 1045166
SGTC_660 4031-1742 102 µM -0.350585393650611 0.348845758447857 no 2226 0.362949708022014 674 6738706
SGTC_895 0964-0006 13.7 µM -0.350760659193113 0.348768360931964 no 2227 0.362883956824139 708 6738897
SGTC_2432 5630864 12.22 µM -0.351984598795836 0.34822804302257 no 2228 0.362424906350874 722 5714970
SGTC_13 0199-0087 65 µM -0.352533764164475 0.347985709587888 no 2229 0.362219000752303 696 4589825
SGTC_106 0092-0003 11.579 µM -0.352605303515244 0.347954145565133 no 2230 0.362192180521399 705 1072148
SGTC_2358 9037157 4 µM -0.353010828647104 0.347775242913051 no 2231 0.362040161212631 698 2388925
SGTC_3022 9087993 49.47 µM -0.353576118047624 0.347525914740917 no 2232 0.361828287345911 687 17173644
SGTC_3137 9097352 49.47 µM -0.355017960133502 0.346890270549984 no 2233 0.361288068138706 748 44120435
SGTC_1970 st070122 35.8 µM -0.355074644029275 0.34686528992258 no 2234 0.361266835858527 732 102928
SGTC_257 daunorubicin 18.5 µM -0.355233617612492 0.346795233719084 no 2235 0.361207290861298 698 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_837 0091-0265 12.5 µM -0.356378973598612 0.34629065516169 no 2236 0.360778386855305 701 759367
SGTC_1194 1488-0194 225 µM -0.356809406378348 0.346101101463527 no 2237 0.360617246957374 692 1391452
SGTC_1435 4092-0789 56.7 µM -0.35837685464257 0.345411155777607 no 2238 0.360030655132081 703 2248285
SGTC_207 4185-0010 4.486 µM -0.358932192672619 0.34516683496793 no 2239 0.359822907940907 686 3761753
SGTC_2838 9002687 71.43 µM -0.360151796755905 0.344630497056423 no 2240 0.359366809916138 721 6457060
SGTC_2087 5276107 200 µM -0.360654470381639 0.34440953009833 no 2241 0.359178882208997 696 144405
SGTC_3106 9121286 49.47 µM -0.36076593928141 0.344360537415078 no 2242 0.359137213470697 686 15943471
SGTC_225 nsc-122657 1.016 µM -0.361015195344875 0.344250994124892 no 2243 0.359044043897631 722 275685
SGTC_68 0986-0284 82.829 µM -0.362858378626079 0.343441356271861 no 2244 0.358355339860268 653 423278 YIL048W NEO1
SGTC_1450 4112-4260 37.6 µM -0.363175054299814 0.343302325274932 no 2245 0.358237060529865 690 1633175
SGTC_52 0329-0193 875 nM -0.36318605368818 0.343297496563966 no 2246 0.358232952469126 740 3739292
SGTC_794 k038-0031 316 µM -0.365032305296753 0.342487358609937 no 2247 0.357543645774942 692 6624242
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.365297901205533 0.34237087422135 no 2248 0.357444522457895 717 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1868 st057644 42.7 µM -0.366682231953696 0.341763980859904 no 2249 0.356928030808507 700 688665
SGTC_1021 4476-0760 85.3 µM -0.368219379677086 0.341090571150604 no 2250 0.356354830528347 693 746768
SGTC_3135 9127742 49.47 µM -0.369199489287689 0.340661458458145 no 2251 0.355989518258504 688 3643468
SGTC_1684 st024538 14.6195 µM -0.369504019427646 0.340528170678547 no 2252 0.355876038876022 692 6732859
SGTC_518 1021-0119 62.6 µM -0.370286561504212 0.340185756389823 no 2253 0.355584492853586 732 1097762
SGTC_1329 1447-1697 50.6 µM -0.370588916995749 0.340053490991849 no 2254 0.355471869076952 701 2840515
SGTC_361 000s-0510 1.45 µM -0.370892212872348 0.339920833996223 no 2255 0.355358907695896 703 660
SGTC_1476 4112-3294 3.34 µM -0.373347478523623 0.338847669082558 no 2256 0.354444922016524 707 704369
SGTC_1449 4112-4002 201 µM -0.373499675542396 0.338781188654105 no 2257 0.35438829338358 690 2059539
SGTC_605 1315-0399 119 µM -0.373627466723281 0.338725372697612 no 2258 0.354340748027144 705 24020461
SGTC_1713 st033146 12.748 µM -0.375387278365149 0.337957092122522 no 2259 0.353686232354889 746 674619
SGTC_75 0159-0059 199.013 µM -0.375996357597634 0.337691343496476 no 2260 0.353459801947782 758 5377270
SGTC_2678 equilin 100 µM -0.37636408092355 0.337530940526321 no 2261 0.353323122756969 668 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1614 st002383 48.6 µM -0.377046771992798 0.337233225145521 no 2262 0.353069423280304 711 1947235
SGTC_202 3594-0513 34.79 µM -0.377084665890668 0.337216702943728 no 2263 0.353055343182717 705 708429
SGTC_1430 4049-0248 69.1 µM -0.377445209376219 0.337059517293093 no 2264 0.352921387419437 727 22774488
SGTC_3194 9111903 49.47 µM -0.377448447513111 0.337058105695824 no 2265 0.352920184409684 746 17087251
SGTC_1817 st052116 64.4 µM -0.37885248864739 0.336446260086078 no 2266 0.352398703644449 703 4361398
SGTC_775 4577-0580 57.3 µM -0.38053579419698 0.335713288695494 no 2267 0.351773865733569 742 2006902
SGTC_38 0929-0051 58.268 µM -0.381411745866698 0.335332114921859 no 2268 0.351448873316293 727 1379719
SGTC_1005 4092-0690 4.4 µM -0.3837866218247 0.334299531876334 no 2269 0.35056830220652 726 1529343
SGTC_2825 7998094 58.44 µM -0.384159720044223 0.334137424469985 no 2270 0.350430035362282 720 2987815
SGTC_2064 5220758 200 µM -0.384203117305401 0.33411857080642 no 2271 0.350413954013848 709 788518
SGTC_1922 5578187 25 µM -0.384931028538713 0.333802396833998 no 2272 0.35014425821856 674 1350412
SGTC_3002 9075603 71.4286 µM -0.385222947877461 0.333675632499332 no 2273 0.350036121445048 690 20105405
SGTC_1404 3909-7820 48.3 µM -0.385565148665805 0.333527057898384 no 2274 0.349909374208275 719 23741373
SGTC_131 0141-0277 33.849 µM -0.386459404970217 0.333138918587528 no 2275 0.3495782309363 735 1547771
SGTC_3130 9127414 49.47 µM -0.386994736015712 0.332906651171272 no 2276 0.349380052488709 720 1494646
SGTC_2826 7992541 19.48 µM -0.387231005874673 0.33280415967832 no 2277 0.349292598929609 756 2985066
SGTC_1651 st011928 86.1 µM -0.387959573049207 0.332488193234169 no 2278 0.34902297551504 711 720198
SGTC_1878 temozolomide 1 mM -0.388534250616662 0.332239049864518 no 2279 0.348810356318903 721 5394 DNA alkylating agent.
SGTC_236 1509-0011 5.31 µM -0.388906959565117 0.332077506764542 no 2280 0.348672486841252 751 3107280
SGTC_2344 7990960 76.95 µM -0.389421451129961 0.331854562148813 no 2281 0.348482203119949 732 140813
SGTC_2212 7123476 200 µM -0.389797791675527 0.331691520202802 no 2282 0.348343038427014 705 1085715
SGTC_2249 haloperidol 116.36 µM -0.391746047910365 0.330847987758868 no 2283 0.34762293129235 726 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.393141387809059 0.330244377426812 no 2284 0.347107528517605 731 4213774
SGTC_2709 st078560 56 µM -0.393679164713229 0.330011858203111 no 2285 0.346908962935942 738 17250903
SGTC_2261 9010538 184.68 µM -0.394051426046708 0.329850941585204 no 2286 0.346771535966669 771 6457250
SGTC_2999 9069765 71.4286 µM -0.395295680519559 0.32931331896382 no 2287 0.346312343418024 720 2097066
SGTC_1241 0364-0022 50.8 µM -0.396547164045264 0.328772928545736 no 2288 0.34585071075525 715 4563895
SGTC_784 4579-0127 173 µM -0.397740167939986 0.32825812268551 no 2289 0.345410862603423 746 1948547
SGTC_1789 tunicamycin 25 nM -0.398104709740664 0.328100880334401 no 2290 0.345276501422648 737 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2679 rapamycin 1 nM -0.398187200175791 0.328065302933534 no 2291 0.345246100172995 729 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.399341002643904 0.327567841672272 no 2292 0.344820979409995 722 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1201 1889-3372 45.9 µM -0.399418550711678 0.327534417831401 no 2293 0.344792413691723 703 5392199
SGTC_2370 9071495 200 µM -0.400221771612088 0.327188304506006 no 2294 0.344496590150039 748 21791103
SGTC_3202 9113761 49.47 µM -0.401133792185792 0.326795488760407 no 2295 0.344160811338582 742 4798415
SGTC_2229 7354935 190 µM -0.402438503687256 0.326233871059955 no 2296 0.343680669010579 737 318112
SGTC_2203 7227154 166.4 µM -0.402795445345261 0.326080292809046 no 2297 0.343549356035867 711 896304
SGTC_1443 4112-3303 14 µM -0.402976120309593 0.326002566570623 no 2298 0.343482895878657 725 704433
SGTC_2818 7996756 12.99 µM -0.403014774740853 0.325985938443959 no 2299 0.343468677715813 710 2241621
SGTC_2806 7952793 58.44 µM -0.403073590649934 0.325960638040035 no 2300 0.343447044031888 708 2972490
SGTC_1565 sinapyl alcohol 95.1 µM -0.403389099821909 0.325824931477284 no 2301 0.343331002117448 732 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1033 k072-0102 21.3 µM -0.403456020258191 0.325796150676061 no 2302 0.343306391179375 750 5965931
SGTC_2728 chlorpromazine 9.18 µM -0.403895002095839 0.325607381345644 no 2303 0.343144965872261 747 2726 A thorazine and dopamine antagonist.
SGTC_836 0330-0104 1.35 µM -0.404306260150515 0.325430574259001 no 2304 0.342993761302195 702 46494820
SGTC_3095 9117207 49.47 µM -0.404820918624978 0.325209368846084 no 2305 0.342804575590737 722 17015229
SGTC_754 3474-0146 171 µM -0.405950303306841 0.324724163821433 no 2306 0.342389557998749 702 24762078
SGTC_2832 7992762 51.95 µM -0.405983629953222 0.32470985057514 no 2307 0.34237731426658 690 2985177
SGTC_2433 5607874 27.82 µM -0.406080683674225 0.324668169073351 no 2308 0.342341659064388 719 2252428
SGTC_2132 5317594 122.667 µM -0.406226304995842 0.32460563344284 no 2309 0.342288163930184 719 794577
SGTC_3322 9139058 2.11 µM -0.40691330178464 0.324310676204914 no 2310 0.342035832968503 713 4908926 YPR165W RHO1
SGTC_2969 9091408 28.7 µM -0.407043910261983 0.324254612836456 no 2311 0.341987869013144 712 4286311
SGTC_2680 butyl paraben 22.24 µM -0.40765861717312 0.323990804924095 no 2312 0.341762161603118 732 7184 An antifungal and steroid mimetic.
SGTC_2595 hexamethylquercetagetin 100 µM -0.408445645418045 0.323653172518316 no 2313 0.341473263999818 764 386331
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.40986352590973 0.32304527298241 no 2314 0.340953031366334 716 16623 A steroid.
SGTC_1235 benzylparaben 21.5 µM -0.410612626654289 0.322724295461773 no 2315 0.340678301781055 741 7180
SGTC_2690 usnic acid 100 µM -0.410616387560934 0.322722684307196 no 2316 0.340676922697225 762 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_602 3130-1533 38.1 µM -0.411435167956265 0.322372001942051 no 2317 0.340376735503568 734 720941
SGTC_976 1348-1067 47.6 µM -0.411440793387686 0.322369593124754 no 2318 0.34037467341672 712 5310671 YGL099W LSG1
SGTC_2323 6148992 148.28 µM -0.411896740174558 0.322174380905234 no 2319 0.340207555110835 714 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2174 5790901 200 µM -0.4127558848945 0.321806674030179 no 2320 0.339892737855098 720 786020
SGTC_1502 4534-4282 27.7 µM -0.412840137847283 0.321770623845914 no 2321 0.339861870968322 746 3278949
SGTC_834 0312-0008 75.7 µM -0.412877729339281 0.321754539725835 no 2322 0.339848099306835 747 6385573 YIL048W NEO1
SGTC_1088 bifonazole 369 nM -0.414284781555507 0.321152750426637 no 2323 0.339332778908888 731 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_3243 9134147 49.47 µM -0.414787772637912 0.320937737419155 no 2324 0.339148635705042 744 24282180
SGTC_2009 4012297 12.05 µM -0.414923074134593 0.320879910490925 no 2325 0.33909910887459 743 45595307
SGTC_2900 5328528 85.29 µM -0.416025112071782 0.320409068993055 no 2326 0.338695813804132 703 795359
SGTC_2196 6573537 42.6665 µM -0.416165841715795 0.320348963578572 no 2327 0.338644326545359 760 2903087
SGTC_1992 st073643 23.3 µM -0.417049661244019 0.319971593401529 no 2328 0.338321041858401 737 3161292
SGTC_1484 3473-2379 286 µM -0.417142376179312 0.319932017087039 no 2329 0.338287135366554 729 671917
SGTC_104 0074-0074 590.992 µM -0.4185476664932 0.319332405760778 no 2330 0.337773371704905 725 3943124
SGTC_1000 4048-0884 8.67 µM -0.419673882209673 0.318852211131329 no 2331 0.337361853660004 743 13040088
SGTC_2720 fluspirilene 36.88 µM -0.420510432337039 0.318495720473935 no 2332 0.337056304960149 737 3396 An atypical antipsychotic.
SGTC_1396 3511-0007 98.6 µM -0.420553521436222 0.318477362867113 no 2333 0.337040569638989 730 X1396
SGTC_340 k038-0059 454 µM -0.420963445943341 0.318302741616109 no 2334 0.336890887252766 707 23733424
SGTC_1708 st033234 31.827 µM -0.423066171111844 0.317407649774093 no 2335 0.336123491573237 724 674664
SGTC_1161 k007-0610 110 µM -0.423321727600116 0.317298936624051 no 2336 0.336030271937861 749 5843850
SGTC_1777 st045864 34.765 µM -0.425353707758442 0.316435098388588 no 2337 0.335289423460451 741 4691462
SGTC_475 α-linolenic acid 10 µM -0.425825933174316 0.316234488370046 no 2338 0.335117344308085 728 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2028 5153890 36.43 µM -0.426526960203578 0.315936778968552 no 2339 0.33486195356131 741 2830968 YPR165W RHO1
SGTC_3198 9112019 49.47 µM -0.42707051410906 0.3157060267604 no 2340 0.334663984302625 780 45595555
SGTC_1884 5633444 25 µM -0.427233704765992 0.315636762264979 no 2341 0.334604557152468 716 5724239
SGTC_717 1532-0246 73.2 µM -0.428334763937199 0.315169599039695 no 2342 0.334203706216128 736 9561992
SGTC_1547 harmine 94.2 µM -0.428739498564013 0.314997950303063 no 2343 0.334056406258664 711 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2041 5107442 45.335 µM -0.428882052130062 0.314937502571343 no 2344 0.334004531104169 735 793005
SGTC_2171 5739187 198.077 µM -0.429196068582382 0.314804366025452 no 2345 0.333890271900221 710 2262761
SGTC_2156 5649887 115 µM -0.429387200928777 0.314723341605602 no 2346 0.333820733305869 721 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2683 piperine 63.03 µM -0.429789583605121 0.314552793551144 no 2347 0.333674355361796 747 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2602 kawain 100 µM -0.429923710679335 0.31449595319495 no 2348 0.333625568514044 737 5369129
SGTC_1074 carmofur 3.8 µM -0.431317194785177 0.313905682995643 no 2349 0.333118874725042 742 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2988 9073640 71.4286 µM -0.4325036188249 0.313403496980988 no 2350 0.332687711309472 758 9102229
SGTC_695 3505-6186 243 µM -0.43297035497714 0.313206033005941 no 2351 0.332518153331204 755 1819379
SGTC_3063 1327-0034 4 µM -0.433075842979322 0.313161411182065 no 2352 0.332479835927899 740 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_880 0833-0487 87.2 µM -0.433316282503317 0.313059714579434 no 2353 0.332392505351304 725 76075
SGTC_2869 9037858 32.47 µM -0.4340334393647 0.312756469497342 no 2354 0.332132079261088 711 27187042
SGTC_1389 3405-0187 19 µM -0.435201382934292 0.312262883417579 no 2355 0.331708129431336 725 799890
SGTC_1035 k081-0041 55.2 µM -0.436328390985587 0.311786916345567 no 2356 0.331299242950893 753 731709
SGTC_1485 3909-9022 254 µM -0.436363993821405 0.311771885386301 no 2357 0.331286329263857 741 714516
SGTC_2369 9071472 200 µM -0.436400918941483 0.311756296510577 no 2358 0.331272936176259 715 17296037
SGTC_1871 st057448 67.3 µM -0.438094150096325 0.311041818769694 no 2359 0.330659017435463 772 691747
SGTC_3326 9140064 16.379 µM -0.438357151635015 0.310930906121933 no 2360 0.330563701168656 745 1868434
SGTC_2635 hydroquinidine 100 µM -0.439093309375347 0.310620546023421 no 2361 0.330296963422521 742 442912 An experimental heart treatment.
SGTC_1362 1611-0397 101 µM -0.439280357705876 0.310541708922791 no 2362 0.330229202479743 730 27816
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.44008632707393 0.310202108637772 no 2363 0.329937292209586 711 6708784 An antioxidant flavonoid
SGTC_1136 pergolide 1.05886 µM -0.440705839792302 0.309941182998802 no 2364 0.32971298415973 748 47811 A dopamine receptor agonist.
SGTC_255 tunicamycin 200.472 nM -0.44111508787824 0.309768868851651 no 2365 0.329564840573326 749 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_152 4469-0003 551.229 µM -0.441733030601183 0.309508762906163 no 2366 0.329341202360285 736 697280
SGTC_2983 9022671 12.99 µM -0.442485039100406 0.309192354354428 no 2367 0.329069127058023 758 6405161
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.444320739771798 0.30842057541597 no 2368 0.328405354327426 716 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1025 k007-0731 70 µM -0.444541485064595 0.308327824945165 no 2369 0.32832557124567 718 6256118
SGTC_3330 9141424 71.43 µM -0.444724401372346 0.30825097833412 no 2370 0.328259466472731 720 27261020
SGTC_1400 3771-8998 51.5 µM -0.445831965390697 0.307785849257429 no 2371 0.327859314902805 721 670767
SGTC_308 4092-1169 104 µM -0.449067080200767 0.306429010586273 no 2372 0.326691633591115 746 2268590 YDL196W YDL196W
SGTC_1931 st074438 57.1 µM -0.449496461881117 0.306249122509091 no 2373 0.32653677991795 775 2787313
SGTC_735 3076-0345 636 µM -0.450164730476537 0.305969246430332 no 2374 0.326295832711047 720 2888990
SGTC_1309 pyrazolanthrone 13.4 µM -0.450494168056475 0.305831317076856 no 2375 0.326177079194677 734 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2687 chenodiol 100 µM -0.450694493118099 0.305747458181952 no 2376 0.326104875934812 712 5702181 A cholesterol synthesis inhibitor.
SGTC_2890 9046729 58.44 µM -0.450826583893009 0.30569216869339 no 2377 0.326057269958333 738 903329
SGTC_2961 9083290 32.55 µM -0.451412571276888 0.305446944257484 no 2378 0.325846112251744 753 17741490
SGTC_355 1311-2252 105 µM -0.451721913015191 0.30531752588273 no 2379 0.325734664978704 743 5338538
SGTC_1183 1254-0324 198 µM -0.452078862769125 0.305168220121914 no 2380 0.32560608520627 719 5799357
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.452534605709311 0.304977638039094 no 2381 0.325441948494012 758 23847180
SGTC_2054 5233173 129 µM -0.452747171723376 0.304888765499532 no 2382 0.325365404001535 713 6889
SGTC_1764 st044502 93.5 µM -0.452852172328073 0.304844869640656 no 2383 0.325327596263027 722 8407
SGTC_3012 9080433 71.4286 µM -0.453289048922 0.304662262059783 no 2384 0.325170308701385 752 17688859
SGTC_1545 lovastatin 49.4 µM -0.453437590243841 0.304600185194628 no 2385 0.325116836843355 729 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_91 0417-1751 58.384 µM -0.454309267046934 0.304236016409088 no 2386 0.324803123511325 752 6795624
SGTC_121 0557-0495 61.343 µM -0.455498388495089 0.303739538717408 no 2387 0.324375363332627 754 3104427
SGTC_2058 5236698 133 µM -0.456159957846706 0.303463479294108 no 2388 0.324137478620666 712 766665
SGTC_1204 4049-0315 18.3 µM -0.45670410041851 0.30323650371723 no 2389 0.323941871599701 744 588402
SGTC_2575 plumbagin 510 nM -0.456914576748038 0.303148729098945 no 2390 0.323866223125002 754 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3170 9103054 49.47 µM -0.457914511760033 0.302731883065813 no 2391 0.323506930312386 765 16432970
SGTC_544 k015-0020 52.4 µM -0.458395924316983 0.302531286711834 no 2392 0.323334009636838 746 3008304
SGTC_474 dl-dihydrosphingosine 5 µM -0.463574617108746 0.300377193518476 no 2393 0.321476271774465 728 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1348 1493-0373 93.8 µM -0.463966672173218 0.300214399554194 no 2394 0.321335811857879 771 3010129
SGTC_2232 chlorophetanol 41.5365 µM -0.46440603099502 0.300032010951767 no 2395 0.321178434981237 743 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_997 3996-0078 137 µM -0.465058789898056 0.29976112736011 no 2396 0.32094467819659 744 735687
SGTC_2512 diallyl trisulfide 49.23 µM -0.466232203817417 0.299274459708342 no 2397 0.320524650263539 764 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2399 5884133 200 µM -0.46732154232575 0.298822983035844 no 2398 0.320134923057993 751 722445
SGTC_1454 4239-0054 42.6 µM -0.467875486718709 0.298593519385816 no 2399 0.319936817189055 761 1340767
SGTC_2905 7799065 20.05 µM -0.467955434725778 0.298560408670249 no 2400 0.319908229803982 770 1296806
SGTC_3303 9125618 40.5795 µM -0.46808155236927 0.298508180051732 no 2401 0.3198631354991 753 22695467
SGTC_773 4358-1457 44.6 µM -0.469719469114155 0.297830253714289 no 2402 0.319277728124964 785 1186886
SGTC_1242 0402-0103 60.1 µM -0.472134596122448 0.296831926629063 no 2403 0.318415359948137 747 432868
SGTC_1266 0828-0227 32.9 µM -0.472525061652203 0.296670666087579 no 2404 0.318276028805429 738 3913820
SGTC_441 propafenone 146 µM -0.473665780265967 0.296199784308703 no 2405 0.317869129604262 726 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_810 3825-7150 143 µM -0.47496443982668 0.295664123196927 no 2406 0.317406159767365 719 22330411 YGL099W LSG1
SGTC_457 grayanotoxin iii 135 µM -0.476776683839933 0.294917367811062 no 2407 0.316760575267478 763 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.477058685968235 0.294801243876508 no 2408 0.316660166368032 742 5106787 A p450 inhibitor.
SGTC_1826 st055655 41.6 µM -0.477502159393906 0.294618671315363 no 2409 0.316502291769153 736 676168
SGTC_3075 9116269 49.47 µM -0.478966042811229 0.294016379087252 no 2410 0.315981393100665 774 17015205 YNL244C SUI1
SGTC_2888 9058547 12.99 µM -0.479435485520207 0.29382335474269 no 2411 0.315814426960371 731 16476514
SGTC_795 0685-0265 78 µM -0.481980509288782 0.292777919766689 no 2412 0.314909896086254 745 302754
SGTC_564 3555-0129 330 µM -0.482048591251789 0.292749977056927 no 2413 0.314885714177753 749 563260
SGTC_24 0417-1663 219 µM -0.482081493784328 0.292736473396686 no 2414 0.314874027871556 771 4329390
SGTC_907 3448-6986 75.5 µM -0.48217586211168 0.292697744917914 no 2415 0.314840511201222 771 590582
SGTC_3180 9109287 49.47 µM -0.48329377707847 0.292239137147198 no 2416 0.314443578969038 728 18891271
SGTC_358 0075-0058 9.45 µM -0.484383596745627 0.291792377092861 no 2417 0.314056828767725 819 1069125
SGTC_167 3672-0051 66.205 µM -0.484545408092188 0.291726071382259 no 2418 0.313999423293523 751 3237971
SGTC_3003 9075612 71.4286 µM -0.4847151368606 0.291656528882675 no 2419 0.313939213808504 777 6501993
SGTC_1728 st035614 33.7865 µM -0.48512797967088 0.291487408204288 no 2420 0.313792782868446 750 15945546
SGTC_1988 st071872 53.4 µM -0.485492257439044 0.291338220147331 no 2421 0.313663601783025 739 16414116
SGTC_1804 st050076 49.1 µM -0.485740899357332 0.291236410614266 no 2422 0.313575440886338 751 3895976
SGTC_948 3448-0295 75.3 µM -0.486083286047776 0.291096243303947 no 2423 0.313454058357494 748 678569
SGTC_690 glyoxal 20.3 µM -0.486277281649484 0.291016838777376 no 2424 0.313385292228087 770 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1291 0993-0025 5.79 µM -0.486866791140694 0.2907756081965 no 2425 0.313176367067874 744 4353356
SGTC_1933 st074711 15.9 µM -0.487707000584844 0.290431951477424 no 2426 0.312878696206534 764 17250958
SGTC_2597 laccaic acid a 100 µM -0.488145252564195 0.290252776133892 no 2427 0.312723479918878 753 5491415 A textile dye.
SGTC_3123 9126162 49.47 µM -0.48832188012777 0.290180578199941 no 2428 0.312660932885156 723 25239884
SGTC_1770 st043884 66.3 µM -0.490069237649338 0.289466785576355 no 2429 0.312042452696116 778 670149
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.490801190819276 0.289168029207211 no 2430 0.311783533860501 728 6708561
SGTC_1271 0832-2808 169 µM -0.490908583274802 0.289124207754496 no 2431 0.311745553008445 754 3663794
SGTC_2866 9034245 58.44 µM -0.492725942516784 0.288383108977692 no 2432 0.31110312226871 738 6462273
SGTC_858 0438-0351 2.77 µM -0.49353783935164 0.288052316186352 no 2433 0.310816305035018 751 2799119
SGTC_2782 7736369 71.43 µM -0.494484872956234 0.287666690771515 no 2434 0.310481893489591 749 2950836 YOL077C BRX1
SGTC_2170 morpholine 200 µM -0.494564388951535 0.287634323523718 no 2435 0.310453822339509 758 121171 Reacts with secondary amines.
SGTC_590 k048-0076 22.4 µM -0.495608095300417 0.287209639073466 no 2436 0.310085470085314 768 6832814
SGTC_2375 9072683 200 µM -0.497273808483155 0.286532475313204 no 2437 0.309497989488363 784 16798029
SGTC_301 4119-0100 24.5 µM -0.497690157340039 0.286363335064048 no 2438 0.309351223293885 772 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2511 berberine 10.47 µM -0.497898322027281 0.286278786672082 no 2439 0.309277855031839 770 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2283 7944793 200 µM -0.498090449686996 0.286200762416113 no 2440 0.309210145815416 740 2970533
SGTC_1802 st050112 57.9 µM -0.501092061733228 0.28498310221767 no 2441 0.308153166680492 746 4662563
SGTC_840 0245-0196 390 µM -0.501131733498958 0.28496702517815 no 2442 0.308139207398766 742 3827528
SGTC_1252 0493-0875 34.8 µM -0.502269341354086 0.284506192117132 no 2443 0.307739036110607 738 3960963
SGTC_127 0180-0333 59.125 µM -0.5024581869325 0.284429727209023 no 2444 0.307672628848102 750 771601
SGTC_927 2425-1185 123 µM -0.502961020292009 0.284226174323364 no 2445 0.30749583898589 763 730375
SGTC_3110 9122132 49.47 µM -0.505749958201876 0.283098445535307 no 2446 0.306516096154527 734 918317
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.506809231525708 0.28267068348128 no 2447 0.306144339187474 751 390807
SGTC_970 1315-0089 19.5 µM -0.509502344273899 0.281584535584088 no 2448 0.305200077773578 755 6811083 YLR033W RSC58
SGTC_116 0155-0182 31.788 µM -0.510073463052538 0.28135445904145 no 2449 0.304999997868924 754 771486
SGTC_3344 9148862 3.898 µM -0.510154977724506 0.281321628065133 no 2450 0.304971445604826 788 4905352
SGTC_1722 st034304 3.6505 µM -0.510883594058777 0.281028251584021 no 2451 0.304716284843564 759 4036148 YLR033W RSC58
SGTC_2457 5731572 11.68 µM -0.511272882364481 0.280871565734423 no 2452 0.304579995357952 778 2865357
SGTC_921 1561-0023 372 µM -0.511298760511388 0.280861151456522 no 2453 0.30457093640328 774 24050882
SGTC_546 peri-Naphthalide 147 µM -0.51436198314856 0.27962972349398 no 2454 0.303499466770474 749 223824 A penicillin ester.
SGTC_1977 st070720 65.3 µM -0.515527369780323 0.279161922464135 no 2455 0.303092274452732 747 682188
SGTC_338 4055-0136 114 µM -0.516285123440993 0.278857954742273 no 2456 0.302827642456209 761 2900563
SGTC_1098 clofazimine 15.1 µM -0.517378353034501 0.278419697127786 no 2457 0.302446033873119 785 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2018 5133068 143 µM -0.518204659615964 0.278088667391084 no 2458 0.302157742035361 794 785362
SGTC_707 0865-0008 204 µM -0.520172009493943 0.277301293671608 no 2459 0.301471846207264 779 723043
SGTC_2785 7756463 72.73 µM -0.521109205973306 0.27692659222171 no 2460 0.301145349106483 784 2201551
SGTC_3062 9077494 49.47 µM -0.522566719906375 0.27634435515874 no 2461 0.30063790252341 733 16459633
SGTC_801 0866-0028 10.1 µM -0.523905049370656 0.275810258437678 no 2462 0.300172291317468 768 6849771
SGTC_3321 9137793 26.8275 µM -0.524750389909705 0.275473163919388 no 2463 0.299878361442792 747 4904192
SGTC_2345 9052315 157.45 µM -0.525029795334632 0.275361790635592 no 2464 0.299781239190025 755 6469265
SGTC_2904 7225135 42.03 µM -0.525272886185143 0.27526491066615 no 2465 0.299696751592939 802 4446116
SGTC_982 1491-0518 27.5 µM -0.52546380814264 0.275188833539588 no 2466 0.299630403152154 765 3091256
SGTC_1674 st016616 23.6 µM -0.52727324559452 0.274468337103386 no 2467 0.299001925335934 761 625830
SGTC_118 0083-0097 135.343 µM -0.528777221343839 0.273870181166401 no 2468 0.29848000056762 791 5207356
SGTC_807 1315-0151 48 µM -0.528893261754391 0.273824056778948 no 2469 0.298439748289267 793 4011080
SGTC_2311 7694451 200 µM -0.529031419861019 0.273769145936404 no 2470 0.298391827011561 797 2163142
SGTC_2718 lomofungin 53.02 µM -0.529071302835533 0.2737532954892 no 2471 0.298377993924657 779 5351222 A RNA synthesis inhibitor.
SGTC_204 PMA1.184 62.41 µM -0.529473963768072 0.273593293840094 no 2472 0.298238350591571 763 2252213 YGL008C PMA1
SGTC_3274 9138298 49.47 µM -0.530554442340584 0.273164182889847 no 2473 0.297863786379612 773 17015756
SGTC_1570 verbenone 133 µM -0.530971015160143 0.272998830544514 no 2474 0.297719432438576 781 29025 A natural terpanoid with antifungal properties.
SGTC_666 0272-0154 136 µM -0.531240294718241 0.272891970466755 no 2475 0.297626136652113 766 6870312
SGTC_3088 9117578 49.47 µM -0.532049231705929 0.272571079195859 no 2476 0.29734594904758 794 678341
SGTC_2971 9092186 9.93 µM -0.53231510983706 0.272465650870071 no 2477 0.297253884440321 728 25236400
SGTC_2131 toluylene red 5.2905 µM -0.532669318267552 0.272325228507157 no 2478 0.297131254278593 738 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_237 nikkomycin 200 µM -0.533209260213823 0.272111243164375 no 2479 0.296944366010405 787 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1835 st008666 49.2 µM -0.533871561317351 0.271848879652878 no 2480 0.296715199453833 763 690455
SGTC_1833 st055984 71 µM -0.535016986771654 0.271395428860965 no 2481 0.296319055561594 743 676288
SGTC_1236 0330-0013 258 µM -0.536138440575474 0.270951833379897 no 2482 0.2959314373566 774 4617066
SGTC_2952 9073731 13.78 µM -0.536584906522799 0.270775332745539 no 2483 0.295777186121471 785 16457353
SGTC_1273 0849-0096 14.1 µM -0.536749332250094 0.270710345063101 no 2484 0.29572038735378 783 5286025
SGTC_3331 9141060 1.957 µM -0.53848806457441 0.270023604863432 no 2485 0.295120071450432 766 4906567 YPR165W RHO1
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.539712561966351 0.269540493672084 no 2486 0.294697637715083 788 1377
SGTC_3172 9105863 49.47 µM -0.54069169681432 0.269154499317496 no 2487 0.294360051259643 769 2348785
SGTC_1609 st001574 46.4 µM -0.540909221809069 0.269068784320317 no 2488 0.294285077164235 792 3960012
SGTC_2973 9094665 17.96 µM -0.541020565292518 0.269024915093998 no 2489 0.294246703943975 793 25237061 YIL048W NEO1
SGTC_433 pimozide 108 µM -0.54235139453523 0.268500847686965 no 2490 0.293788228340007 768 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2895 9054447 58.44 µM -0.542380337297818 0.268489456017788 no 2491 0.293778261124316 769 2697450
SGTC_412 gemfibrozil 100 µM -0.543884883759165 0.267897611862983 no 2492 0.29326034585239 764 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1154 4088-0362 150 µM -0.54504319235939 0.26744241554881 no 2493 0.292861905821472 781 6618304
SGTC_440 fluspirilene 35.1 µM -0.546115137501879 0.267021506484408 no 2494 0.292493397502047 781 3396 An atypical antipsychotic.
SGTC_576 1073-0113 22.7 µM -0.546730677578108 0.26677996033587 no 2495 0.292281887452287 806 5439563
SGTC_567 1080-0542 68.4 µM -0.546849494426791 0.266733347735083 no 2496 0.292241068153131 742 5950415
SGTC_3138 9097216 49.47 µM -0.548363085688933 0.266139916767147 no 2497 0.291721309018885 793 25237486
SGTC_2053 5265679 138 µM -0.548783181186374 0.26597532929282 no 2498 0.291577126890541 784 764595
SGTC_1018 4259-0013 28.1 µM -0.54984381904229 0.265560015947215 no 2499 0.291213250388357 782 6801262
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.55232084160837 0.26459137250754 no 2500 0.290364276898166 802 165506
SGTC_1142 3253-1408 9.78 µM -0.554290826273355 0.263822292221427 no 2501 0.289689913778472 787 256655
SGTC_2833 9001315 45.46 µM -0.554373632683406 0.263789989652128 no 2502 0.289661583678838 758 2989378
SGTC_1759 st043059 70 µM -0.55500049929521 0.263545516029978 no 2503 0.289447159464564 800 669426
SGTC_212 3807-4682 38.772 µM -0.555385334879014 0.263395490125162 no 2504 0.289315560643161 771 3125501 YBL034C STU1
SGTC_2246 7293507 91.5585 µM -0.555859193708628 0.26321081894429 no 2505 0.289153557966198 791 887656
SGTC_463 ikarugamyin 104 µM -0.556183450915492 0.263084488290945 no 2506 0.289042725620816 796 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_606 k015-0008 38.6 µM -0.556752112783151 0.262863012388632 no 2507 0.288848403099113 797 1970475
SGTC_2654 protoveratrine a 100 µM -0.557158861749032 0.262704654972336 no 2508 0.288709447012671 805 5702278 A heart drug and vasodilator.
SGTC_2430 5571206 200 µM -0.557516731850271 0.262565367676393 no 2509 0.288587215263264 791 1731771
SGTC_3070 9117005 49.47 µM -0.558440131349245 0.262206144284138 no 2510 0.288271937687171 782 8779016
SGTC_190 3970-0790 3.722 µM -0.560376893466935 0.261453518574324 no 2511 0.287611194486085 780 2832352
SGTC_300 r073-0011 5.04 µM -0.560737132359653 0.261313652201922 no 2512 0.287488374865097 793 2735780
SGTC_1562 morin hydrate 59.1 µM -0.560827863633894 0.261278430932782 no 2513 0.287457444912041 793 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2183 6420625 130.508 µM -0.560942599738333 0.261233894642804 no 2514 0.287418334055387 784 2897619
SGTC_1771 st048882 4.1505 µM -0.561273376930939 0.261105521070402 no 2515 0.287305593930433 772 4580403
SGTC_2144 5628481 200 µM -0.56306038101857 0.260412551712551 no 2516 0.286696884286745 779 2818399
SGTC_1932 st074806 40.9 µM -0.564324255094283 0.259923015673654 no 2517 0.286266738645132 795 17251235
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.565661661248534 0.259405515851383 no 2518 0.285811901148031 782 4174840
SGTC_2099 5377090 177.372 µM -0.566919317576893 0.258919360699629 no 2519 0.285384499510669 796 2243829
SGTC_766 1391-0721 126 µM -0.572860542760068 0.256629130791507 no 2520 0.283369561201064 806 1020919 YIL115C NUP159
SGTC_2897 9048598 12.99 µM -0.573210571308358 0.256494531236337 no 2521 0.283251063767074 787 6467404
SGTC_582 0987-0078 156 µM -0.573306775388003 0.256457543480022 no 2522 0.283218499340669 801 1625765
SGTC_3079 9117512 49.47 µM -0.573704096004291 0.256304814348801 no 2523 0.283084028043482 820 7185044
SGTC_137 0438-0332 85.389 µM -0.574077865978898 0.256161181320027 no 2524 0.282957555327509 814 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2773 thioridazine 9.09 µM -0.574085392239002 0.256158289545798 no 2525 0.282955008942116 793 5452 An antipsychotic.
SGTC_439 amiodarone 34.4 µM -0.57485537627153 0.255862532725869 no 2526 0.282694555761346 781 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1169 aniline yellow 25.8 µM -0.575698942518314 0.255538717106162 no 2527 0.282409345125973 793 6051 A DNA damaging agent.
SGTC_2385 9074692 200 µM -0.575718135407772 0.255531352117873 no 2528 0.282402857600496 763 17046906
SGTC_2148 5546263 113.568 µM -0.576453296020904 0.25524932856738 no 2529 0.282154414692552 773 792097
SGTC_2695 st077686 51.995 µM -0.576867198899006 0.255090618082009 no 2530 0.282014585126748 771 2876092
SGTC_1681 tripelennamine 100 µM -0.576947346949993 0.255059891389312 no 2531 0.281987512421673 766 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_737 1950-0117 57.9 µM -0.5770022046182 0.255038861492327 no 2532 0.281968983117264 786 5393513
SGTC_2252 omeprazole 400 µM -0.577248399368191 0.254944492964491 no 2533 0.281885833005699 772 4594 A proton pump inhibitor.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.577341387777508 0.254908854476086 no 2534 0.28185443006241 775 803109
SGTC_1578 josamycin 24.2 µM -0.577702069314009 0.254770645310238 no 2535 0.281732640922457 799 5282165 A P450 substrate.
SGTC_2360 9040895 200 µM -0.579124781013518 0.254225860779953 no 2536 0.281252490064206 777 4914414
SGTC_2776 terbinafine 19.92 µM -0.57948226756008 0.254089068179237 no 2537 0.281131904098604 770 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2878 9043973 25.97 µM -0.579538982829965 0.25406736957111 no 2538 0.281112775420718 789 6465167
SGTC_1493 4348-0038 111 µM -0.579788611580522 0.253971876046524 no 2539 0.28102858920302 807 800424
SGTC_77 0828-0286 12.516 µM -0.581612307188413 0.253274807367289 no 2540 0.280413925595662 783 745345
SGTC_2134 5324836 1.464 µM -0.581983537948551 0.253133035664832 no 2541 0.280288884691649 808 699272
SGTC_1857 st056007 79.3 µM -0.581984533554469 0.253132655502615 no 2542 0.280288549380041 776 619834
SGTC_2118 5526350 200 µM -0.584289518972308 0.252253325521771 no 2543 0.279512771258 795 743594
SGTC_933 2914-0560 114 µM -0.585177276421523 0.251915084649624 no 2544 0.279214261257466 770 463887
SGTC_2555 cholic acid 100 µM -0.590185493144905 0.250011417516194 no 2545 0.277533148405616 780 6708657 Influences liver metabolism.
SGTC_694 1315-0438 43.2 µM -0.590838735966475 0.249763678149113 no 2546 0.277314238973557 792 6793154
SGTC_288 1315-0019 35.1 µM -0.591795554332612 0.249401044560028 no 2547 0.276993750267476 802 6811474
SGTC_3166 9102297 49.47 µM -0.592584119799744 0.249102389211531 no 2548 0.276729754656266 797 25237072
SGTC_789 1309-1135 70.6 µM -0.593121822282312 0.248898852964534 no 2549 0.276549813563096 782 3092424
SGTC_2265 7929201 200 µM -0.595334526005082 0.248062211812744 no 2550 0.275809940804118 811 1265108
SGTC_1366 1683-0113 21.9 µM -0.596088953693247 0.247777299966278 no 2551 0.275557901600361 782 708623
SGTC_384 k007-0144 5.16 µM -0.596887132891887 0.247476055544522 no 2552 0.275291369259921 804 6824886
SGTC_2393 9031399 185.94 µM -0.59735860777291 0.247298206063238 no 2553 0.275133991437629 813 1526623 YDL150W RPC53
SGTC_1944 st076371 56.9 µM -0.59867794592956 0.246800889446595 no 2554 0.274693833336182 802 24208455
SGTC_2681 menadione 3.18 µM -0.600304631151751 0.246188457974844 no 2555 0.274151616433494 812 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_138 0850-0259 40.9225 µM -0.600522511306563 0.24610649010762 no 2556 0.274079031425407 789 6813004
SGTC_3211 9128781 49.47 µM -0.600570937520206 0.24608827385383 no 2557 0.274062899914572 784 17194361
SGTC_1915 st067105 30.6 µM -0.600927723482502 0.245954085706215 no 2558 0.273944063528399 809 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1402 3909-7673 35.9 µM -0.601792049451437 0.245629173249476 no 2559 0.273656284026956 779 5328014
SGTC_1513 0337-0559 19 µM -0.60191239089757 0.245583953473123 no 2560 0.273616227905558 793 775073
SGTC_1155 4088-0394 48.2 µM -0.605937130665373 0.244074186900945 no 2561 0.272278250955362 799 2326248
SGTC_2233 sulbentine 40.3845 µM -0.607937123254268 0.243325812636258 no 2562 0.271614588428588 800 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_833 3852-0053 558 µM -0.607983540898609 0.24330845842385 no 2563 0.271599195114932 811 3123681
SGTC_1787 fluconazole 80 µM -0.608312844361184 0.243185360608809 no 2564 0.271490001885906 794 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1919 st067113 52.3 µM -0.608856482429168 0.242982215495262 no 2565 0.271309785635307 807 1268243
SGTC_3147 9097027 49.47 µM -0.609084171701368 0.242897160503716 no 2566 0.27123432426347 821 25236841
SGTC_53 0973-0023 39.979 µM -0.611865755667302 0.241859381176742 no 2567 0.270313289997945 818 674768
SGTC_86 0417-1630 471.922 µM -0.611898408322843 0.241847213121737 no 2568 0.270302487387513 804 3634867
SGTC_949 1165-0505 146 µM -0.613766778409165 0.241151516131299 no 2569 0.269684726666036 790 6244267
SGTC_1888 azatryptophan 97.5 µM -0.613981763074028 0.241071535360623 no 2570 0.269613689205235 783 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2428 5615643 7.78 µM -0.614458692903799 0.240894154600244 no 2571 0.269456130583686 819 2253075
SGTC_2859 9028643 45.46 µM -0.614750060907843 0.2407858233369 no 2572 0.269359896915127 786 17151580
SGTC_485 niflumic acid 177 µM -0.614795225969929 0.240769033241069 no 2573 0.269344981241364 801 4488 A COX2 inhibitor.
SGTC_2059 5238311 157 µM -0.615149788571455 0.240637246854495 no 2574 0.269227902022192 801 703021
SGTC_2606 farnesol 9.78 µM -0.615589032276628 0.240474040052646 no 2575 0.269082895879884 816 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_945 3381-0768 11.3 µM -0.61584665868333 0.240378343611683 no 2576 0.268997864723764 809 1126236 YIL048W NEO1
SGTC_2172 5754775 163.918 µM -0.618661933145791 0.239333950940595 no 2577 0.268069546242179 794 2263357
SGTC_725 1497-0963 19 µM -0.619506626788745 0.239021075956526 no 2578 0.267791328852739 806 3549977
SGTC_335 4077-0256 27.6 µM -0.620958659982764 0.238483765037876 no 2579 0.267313411792736 821 3121989
SGTC_3057 9095946 49.47 µM -0.621742939652655 0.238193825160496 no 2580 0.267055455871763 821 24540043
SGTC_203 k066-0004 30.888 µM -0.621830484178978 0.238161472864017 no 2581 0.267026669569871 806 6795412
SGTC_2699 st077704 54.6 µM -0.621947735163767 0.238118146244432 no 2582 0.266988117675462 804 645852
SGTC_3203 9113543 49.47 µM -0.623263674557396 0.237632176318142 no 2583 0.266555632284318 793 17018012
SGTC_401 neomycin 50 µM -0.62381795818406 0.237427645113433 no 2584 0.266373572266424 777 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2528 xanthyletin 44.79 µM -0.624514792078169 0.237170649904061 no 2585 0.266144779489551 821 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_119 0121-0043 24.815 µM -0.62735602604074 0.236124374674575 no 2586 0.265212942938668 823 1092378
SGTC_3265 9137266 49.47 µM -0.628280631326268 0.235784440926406 no 2587 0.264910058771334 762 17224265
SGTC_954 1189-0853 2.85 µM -0.628609902712311 0.235663448558 no 2588 0.264802237816093 821 2828194
SGTC_1314 1222-0010 41.1 µM -0.62870174142871 0.235629708084574 no 2589 0.264772168918011 820 3526027
SGTC_1965 Pectolinarigenin 58.4 µM -0.629635734989825 0.23528672112963 no 2590 0.264466468884478 812 5320438 An anti-inflammatory.
SGTC_2466 5983409 37.09 µM -0.630380244239158 0.235013515333263 no 2591 0.26422291658664 800 2879657
SGTC_3192 9110362 49.47 µM -0.630975925471824 0.234795049876537 no 2592 0.264028132886279 822 16649480
SGTC_1193 1488-0126 41.5 µM -0.631222359063258 0.234704703458496 no 2593 0.263947572185048 796 1384710
SGTC_3241 9133421 49.47 µM -0.631593236142151 0.23456877034697 no 2594 0.263826353740611 836 17018221
SGTC_1436 4092-1007 8.32 µM -0.631821489443975 0.234485133063234 no 2595 0.263751764941156 784 2881121
SGTC_2868 9035608 32.47 µM -0.632699985817592 0.23416338568888 no 2596 0.26346478956721 806 6462614
SGTC_1103 duloxetine 36.1 µM -0.63364108266549 0.233818982395475 no 2597 0.263157541629464 811 60835 A selective serotonin reuptake inhibitor.
SGTC_482 fipronil 114 µM -0.634469305376206 0.233516118841606 no 2598 0.262887296199038 809 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_499 genistein 192 µM -0.634624156866676 0.233459517074581 no 2599 0.262836784588534 824 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.635092010383174 0.233288552137029 no 2600 0.262684203784816 800 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_911 3456-4043 236 µM -0.635108061237625 0.233282688001399 no 2601 0.262678969932832 804 914281
SGTC_73 0327-0325 16.231 µM -0.63634474435741 0.232831115257551 no 2602 0.262275873600885 780 53298
SGTC_1403 3909-7815 62.9 µM -0.637554570515592 0.232389819649974 no 2603 0.261881838121343 801 6615483
SGTC_219 mitoxanthrone 164.414 µM -0.63769293483311 0.232339379611666 no 2604 0.261836792777208 820 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1059 3448-6867 171 µM -0.638137147644113 0.232177485165027 no 2605 0.261692203462184 820 3934407
SGTC_2295 7971645 200 µM -0.638784662559168 0.231941609266857 no 2606 0.261481513617656 807 2978226 YKL099C UTP11
SGTC_554 4483-2211 187 µM -0.638985427218547 0.231868502086871 no 2607 0.261416206058584 801 747107
SGTC_1629 st005085 44.9 µM -0.639378250439416 0.231725495128668 no 2608 0.261288447216271 823 24207091
SGTC_3097 9117246 49.47 µM -0.639505676277255 0.231679116419773 no 2609 0.261247011095389 807 16423892
SGTC_1524 corynanthine 62.1 µM -0.639593833659473 0.231647033132264 no 2610 0.261218346201245 824 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_66 0109-0187 42.4 µM -0.639784215783114 0.231577755443989 no 2611 0.261156447842097 783 759417
SGTC_377 3970-0964 33.1 µM -0.64000183322763 0.231498581307684 no 2612 0.261085703780087 811 16481235
SGTC_1518 st038567 90.8 µM -0.640005195740275 0.23149735806812 no 2613 0.261084610756572 833 77966
SGTC_1846 st056244 14.8 µM -0.640126392006894 0.231453270805211 no 2614 0.261045216082715 813 5393182
SGTC_2706 st078239 82.5 µM -0.641094918426606 0.231101120610959 no 2615 0.260730507775983 821 15434492
SGTC_430 0958-0115 16.4 µM -0.642086791745757 0.23074079174767 no 2616 0.260408415709101 810 6833180
SGTC_1611 st001856 99.4 µM -0.644445371661213 0.229885225832743 no 2617 0.259643335489041 836 647478
SGTC_2682 pyrogallin 40.03 µM -0.644448456507052 0.22988410798075 no 2618 0.259642335581797 804 822798 An ATP competetive kinase inhibitor.
SGTC_3345 9148410 3.559 µM -0.644756513517329 0.229772493046595 no 2619 0.259542493460956 820 4903596
SGTC_3046 9092212 49.47 µM -0.644910565692439 0.229716688387444 no 2620 0.259492572166029 824 25236637
SGTC_1781 st038725 66.3 µM -0.644931446740337 0.229709124912516 no 2621 0.259485805950916 812 4270275 YIL048W NEO1
SGTC_2945 9067681 61.76 µM -0.647782639384585 0.228677684479933 no 2622 0.258562772741778 844 16456930
SGTC_1486 3970-0793 4.53 µM -0.650130341430798 0.227830341494094 no 2623 0.257804015909722 824 2844330
SGTC_2807 7945238 51.95 µM -0.651413916147542 0.227367816126336 no 2624 0.257389664902844 816 17148797
SGTC_2850 9015429 58.44 µM -0.653636693981966 0.226568109429894 no 2625 0.256672948892912 839 6457570
SGTC_345 1362-0200 395 µM -0.654603791697007 0.226220665216875 no 2626 0.256361441105236 817 1419823
SGTC_613 3914-0030 117 µM -0.654893329970053 0.22611670287876 no 2627 0.2562682174857 799 1145395
SGTC_2552 juarezic acid 87.02 µM -0.655038492455021 0.226064590636891 no 2628 0.256221485680103 808 1549512
SGTC_2582 agaric acid 100 µM -0.655477647720357 0.225906978534708 no 2629 0.25608013655096 813 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_161 4065-0411 162.148 µM -0.656823314005098 0.225424408221585 no 2630 0.255647265774629 817 1906281 YLR208W SEC13
SGTC_2620 irigenin 100 µM -0.65757052764554 0.225156701617001 no 2631 0.255407068947717 822 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_3053 9095903 49.47 µM -0.65878225605867 0.224722954916751 no 2632 0.255017801586798 858 17174018
SGTC_1371 2421-0008 32.7 µM -0.659475038141372 0.224475181766729 no 2633 0.25479538510609 824 2827552
SGTC_2505 galangin 7.89 µM -0.65964454137275 0.224414582638206 no 2634 0.254740981855868 821 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_447 ml7 120 µM -0.663538426535823 0.223025038081143 no 2635 0.253492888737158 833 4216 Selective myosin light chain kinase inhibitor.
SGTC_680 0417-1641 114 µM -0.66379698985737 0.222932942799956 no 2636 0.253410126269178 805 2835990
SGTC_275 trichlorophene 5.69 µM -0.66916907410366 0.221024416720503 no 2637 0.251693815743829 818 62616
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.671598348517645 0.220164454582881 no 2638 0.250919714966877 845 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1455 4262-0120 131 µM -0.671734887414704 0.220116176896227 no 2639 0.250876243578741 825 1529587
SGTC_524 r073-0010 27.8 µM -0.672826269122269 0.219730502356349 no 2640 0.250528911734742 833 2772106
SGTC_2331 7980721 200 µM -0.673540421548816 0.219478343950925 no 2641 0.250301770962099 819 2981221
SGTC_3186 9110464 49.47 µM -0.673656947550809 0.219437215839005 no 2642 0.250264719481478 819 17018021
SGTC_1213 1315-0166 115 µM -0.674451812819344 0.219156784517995 no 2643 0.250012055763797 810 768401
SGTC_3167 9103034 49.47 µM -0.674558297501198 0.219119231996238 no 2644 0.249978217775879 824 5127859
SGTC_18 0111-0177 500 nM -0.67463436701605 0.219092407848383 no 2645 0.249954046404011 829 721752
SGTC_2630 antimycin a 100 µM -0.674892843912493 0.219001276083058 no 2646 0.249871923675447 837 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_722 3534-0461 190 µM -0.675108200936383 0.218925363837789 no 2647 0.249803511840155 814 658262
SGTC_2881 9058953 51.95 µM -0.675317227649797 0.218851697472409 no 2648 0.249737120447446 790 17122249
SGTC_655 k060-0012 42 µM -0.675484715168458 0.218792680876251 no 2649 0.249683929561594 836 5994525
SGTC_1664 st014217 9.02 µM -0.67744659363726 0.21810206747395 no 2650 0.249061322135981 830 3982782
SGTC_934 2950-0684 338 µM -0.678760737908947 0.217640170688144 no 2651 0.248644737301131 826 1121253
SGTC_506 n9-isopropylolomoucine 153 µM -0.678800008527375 0.21762637650214 no 2652 0.248632294195738 818 6610355
SGTC_1934 st074720 32.6 µM -0.679306087938401 0.217448656344888 no 2653 0.248471969912291 832 17250992
SGTC_2390 9097792 176.6 µM -0.679501985557014 0.217379885380783 no 2654 0.248409924987745 811 4497149
SGTC_631 k072-0230 41.5 µM -0.679689116163512 0.217314203855111 no 2655 0.248350664473898 828 5773147
SGTC_2805 7950783 58.44 µM -0.680221014757291 0.217127573789699 no 2656 0.248182264007244 825 1178958 YDL195W SEC31
SGTC_1374 2889-5571 141 µM -0.680275379661641 0.217108503706353 no 2657 0.248165055369247 824 2853281
SGTC_723 4182-0001 115 µM -0.682402625338308 0.216363070049048 no 2658 0.247492198076998 837 744821 YLR208W SEC13
SGTC_1317 1273-0028 910 nM -0.684270557604292 0.215709728771904 no 2659 0.246902167536788 829 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1244 0416-0015 52.5 µM -0.685918177963681 0.215134395844336 no 2660 0.246382353264098 823 96201
SGTC_2104 5389443 200 µM -0.68640428110115 0.214964823711692 no 2661 0.246229102790752 825 2244536
SGTC_2655 perillic acid 100 µM -0.688524022092557 0.214226281486591 no 2662 0.245561424087595 839 5702197 An apoptosis inducer.
SGTC_3028 9087778 49.47 µM -0.6887239633077 0.21415669592782 no 2663 0.245498496581727 822 17217395
SGTC_1956 st077085 54 µM -0.689399325037098 0.213921746989233 no 2664 0.245286004032601 858 24208685
SGTC_105 0111-0055 734.78 µM -0.69069349441318 0.21347194304174 no 2665 0.244879089257242 820 5179370
SGTC_331 k048-0133 24.5 µM -0.691786890592796 0.213092350148321 no 2666 0.244535585231512 822 6813582
SGTC_904 1141-0088 396 µM -0.692256022255051 0.212929603124471 no 2667 0.24438828129129 839 1378119
SGTC_1950 st077106 7.18 µM -0.692609564378997 0.212807003348441 no 2668 0.244277303231947 816 13831864
SGTC_3338 9144300 39.5675 µM -0.693793279169901 0.212396820024999 no 2669 0.243905929012772 817 4901274
SGTC_1205 4161-2785 76 µM -0.694976428581038 0.211987294622477 no 2670 0.243535036822374 823 3498106
SGTC_612 0302-0167 22.4 µM -0.695356407177038 0.211855870061585 no 2671 0.243415986269826 864 235821
SGTC_217 ketoconazole 989 nM -0.696579643563497 0.211433108769538 no 2672 0.243032949461599 810 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1840 st055363 71 µM -0.697876057819689 0.210985596286269 no 2673 0.242627354284721 836 676033
SGTC_198 3454-2873 16.191 µM -0.698035562353108 0.210930574905899 no 2674 0.242577477151066 829 710957
SGTC_1075 aripiprazole 15.2 µM -0.698597727359008 0.210736722148634 no 2675 0.242401732199813 826 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2215 7188065 200 µM -0.700029120107594 0.21024360349134 no 2676 0.241954559447612 841 940217
SGTC_1726 st035556 14.5795 µM -0.70093438360945 0.20993208788529 no 2677 0.241671982704522 820 5919439
SGTC_3325 9138760 55.175 µM -0.701097720148919 0.20987591007899 no 2678 0.241621016515863 822 43844959
SGTC_1039 k821-0043 94 µM -0.701745657586523 0.209653146189946 no 2679 0.241418896954572 816 15992768
SGTC_825 1988-2224 89.6 µM -0.702163619028566 0.209509522918556 no 2680 0.241288565547679 833 1180859
SGTC_163 TUB2.036 7.546 µM -0.703965006105612 0.208891178460024 no 2681 0.240727283279902 842 15992207 YJR013W GPI14
SGTC_1324 1418-0026 34.4 µM -0.705544761547829 0.208349797220939 no 2682 0.240235643141944 840 1372513
SGTC_928 2764-0428 58.7 µM -0.707514861584384 0.207675806096628 no 2683 0.239623290212186 846 662578
SGTC_868 0527-0199 213 µM -0.708071802208377 0.207485504880511 no 2684 0.239450334702047 839 2849450
SGTC_1441 4106-0040 13 µM -0.708191815288097 0.207444511075663 no 2685 0.239413074087007 833 2904180
SGTC_480 am 92016 50 µM -0.708960435232743 0.207182081097797 no 2686 0.239174514762611 872 2129 K+ channel blocker.
SGTC_1165 k072-0275 30.3 µM -0.709545509105253 0.206982450960111 no 2687 0.238993010400425 844 6153523 YGL055W OLE1
SGTC_861 0443-0273 110 µM -0.711328925020788 0.206374643195243 no 2688 0.238440215670277 850 6149169
SGTC_22 0964-0034 14.468 µM -0.711762265924751 0.20622711572225 no 2689 0.238306001391108 854 138402
SGTC_2860 9025725 38.96 µM -0.712174849785403 0.206086712931006 no 2690 0.238178254443762 839 40546248
SGTC_3224 9130643 49.47 µM -0.715728578924447 0.204879723055689 no 2691 0.237079480240869 832 17644395
SGTC_1055 3448-0672 86 µM -0.716439604007512 0.204638735842529 no 2692 0.236859973937014 825 748378
SGTC_888 0916-0002 6.97 µM -0.717240292180593 0.204367561164025 no 2693 0.236612920842157 832 2802138 YIL048W NEO1
SGTC_1994 st072947 40.9 µM -0.717523613183675 0.204271658116536 no 2694 0.23652553584825 847 5286565 YDL195W SEC31
SGTC_1928 4'-methoxychalcone 40.3 µM -0.717564340944195 0.204257874132749 no 2695 0.236512975602539 836 641818
SGTC_3036 9090181 49.47 µM -0.71763502184677 0.204233954063024 no 2696 0.236491178822973 851 25236586
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.717785419100097 0.204183061668059 no 2697 0.236444802565543 841 115019
SGTC_2524 avocatin b 10.57 µM -0.717811160692061 0.204174351818783 no 2698 0.236436865430991 820 6710748
SGTC_362 0310-0100 9.03 µM -0.718340618704082 0.203995255050563 no 2699 0.236273645455491 824 790235
SGTC_908 3448-7491 47.7 µM -0.719295633198049 0.203672444484822 no 2700 0.23597939296304 797 1203031
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.719654145569768 0.203551340097618 no 2701 0.235868982757053 862 65057 A dermal irritant. YDR527W RBA50
SGTC_2247 cerulenin 830 nM -0.721607419511011 0.202892284891464 no 2702 0.23526793811227 826 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1151 3909-8316 15.3 µM -0.72345826491732 0.202268967767467 no 2703 0.234699193023777 847 800431
SGTC_2830 7992007 71.43 µM -0.723487904509994 0.202258995242595 no 2704 0.234690091281333 834 1952075
SGTC_517 1365-0151 113 µM -0.725598063149192 0.20154976823 no 2705 0.234042604408954 856 768657
SGTC_977 1348-1378 135 µM -0.725751964534965 0.201498100142578 no 2706 0.233995419628214 840 X977
SGTC_2993 9054257 71.4286 µM -0.725829558562784 0.201472053126948 no 2707 0.233971631995422 845 6470217 YGL055W OLE1
SGTC_3094 9117742 49.47 µM -0.726293164900735 0.20131647028886 no 2708 0.233829534317389 864 17149698
SGTC_1747 st037496 66.6 µM -0.727203630215714 0.201011134589914 no 2709 0.233550611350938 859 723305
SGTC_1364 1653-0028 37.6 µM -0.729382910936193 0.200281415254396 no 2710 0.232883734107276 835 5718652
SGTC_2856 9022925 19.48 µM -0.729405075626989 0.200274001724111 no 2711 0.23287695697404 831 4944862
SGTC_303 1348-1668 34.2 µM -0.729440721349313 0.20026207947447 no 2712 0.232866058075496 849 5380509
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.730317635151587 0.199968916735599 no 2713 0.232598025547862 837 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2417 cerulenin 830 nM -0.730762610119172 0.199820255042989 no 2714 0.232462082632787 844 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2767 sibutramine 71.45 µM -0.731990173240116 0.199410483252822 no 2715 0.232087282837136 842 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2753 fluvastatin 17.09 µM -0.733087441637917 0.19904463358217 no 2716 0.231752549573415 870 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1070 indatraline 8.81 µM -0.733939153646015 0.198760935961279 no 2717 0.231492911398994 851 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2600 tangeritin 87.95 µM -0.734723023597726 0.198500051475795 no 2718 0.231254097756368 858 68077 A bioactive flavone.
SGTC_2253 7938677 135.83 µM -0.735756355826226 0.198156457766489 no 2719 0.23093949310413 849 2301972
SGTC_3082 9117008 49.47 µM -0.736902824469493 0.19777566550416 no 2720 0.230590723145335 852 41448529
SGTC_903 1134-0042 114 µM -0.73726378603401 0.197655866000162 no 2721 0.230480975121245 860 701009
SGTC_2285 7945142 200 µM -0.738620460517672 0.197205991773628 no 2722 0.230068748234036 852 2970608
SGTC_145 3737-0113 38.366 µM -0.739625975396522 0.196872962386699 no 2723 0.229763487923861 840 6849351
SGTC_1024 4507-0395 26 µM -0.74174937445802 0.196170806276051 no 2724 0.22911959935546 845 4201836
SGTC_1207 2099-0101 141 µM -0.743139917742438 0.195711811588783 no 2725 0.228698487197677 848 5837381
SGTC_1013 4112-3890 241 µM -0.743705692803925 0.195525245599007 no 2726 0.228527272329207 854 705171
SGTC_2026 5148700 152 µM -0.744341553770064 0.195315697524654 no 2727 0.228334934026268 856 79838
SGTC_108 0509-0257 621.132 µM -0.744377187776451 0.19530395837146 no 2728 0.228324157972294 858 536624
SGTC_1474 0330-0125 5.35 µM -0.744666211221577 0.195208759251321 no 2729 0.228236765163978 861 X1474
SGTC_951 1171-0579 82.7 µM -0.746289518480838 0.194674595221575 no 2730 0.227746270863191 861 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3256 9138902 49.47 µM -0.746604908889644 0.194570916407114 no 2731 0.227651042197374 875 17228773
SGTC_2940 9060638 45.86 µM -0.746669722195576 0.194549614384049 no 2732 0.22763147530943 840 4027022
SGTC_1870 st057514 26.5 µM -0.746974068909667 0.194449604511872 no 2733 0.227539606869611 859 5393161
SGTC_2335 9018011 154.17 µM -0.747166736497996 0.194386309145674 no 2734 0.227481460076056 838 6458208
SGTC_547 1120-0019 610 nM -0.747351710547715 0.194325553072704 no 2735 0.227425643056321 833 3676939
SGTC_1424 4048-1941 275 µM -0.748521357729584 0.193941641719765 no 2736 0.227072873742817 848 X1424
SGTC_1854 st056233 32.9 µM -0.749051703849984 0.193767719499694 no 2737 0.226913021376611 862 5393174
SGTC_583 1488-1091 88.9 µM -0.749238557668584 0.193706465136292 no 2738 0.22685671662976 876 4303273
SGTC_2079 5212404 121 µM -0.750252449259109 0.193374297380151 no 2739 0.226551337652463 828 758462
SGTC_2656 pseudo-anisatin 100 µM -0.750321503762191 0.193351686624517 no 2740 0.226530547232838 880 6708809 A neurotoxin.
SGTC_1419 3993-2473 62.6 µM -0.750820133116908 0.193188466570144 no 2741 0.226380455564579 863 704026
SGTC_2307 7538926 6.34 µM -0.754144648694973 0.192102379293164 no 2742 0.225381184933049 866 96582
SGTC_2047 4141938 200 µM -0.755397989399177 0.191693896555433 no 2743 0.225005109630786 862 3807862
SGTC_1964 st076914 61 µM -0.755442917484781 0.191679263693769 no 2744 0.224991635190889 881 24208661
SGTC_103 0844-0104 51.839 µM -0.755567434700483 0.19163871261007 no 2745 0.224954293462832 867 5375804
SGTC_2484 5809818 12.04 µM -0.755718930095958 0.191589382723434 no 2746 0.224908865929221 840 2870548
SGTC_820 1582-0060 59.9 µM -0.756511689739861 0.191331371427022 no 2747 0.224671233193856 861 3848840
SGTC_1778 st046819 58.9 µM -0.7566176832103 0.19129689097353 no 2748 0.224639472042205 874 671715
SGTC_3059 1327-0034 3 µM -0.757739418234969 0.190932215826513 no 2749 0.224303498081055 846 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2071 5230951 39.92 µM -0.758603298436115 0.190651659953294 no 2750 0.224044949489233 867 1799272
SGTC_752 1896-0090 130 µM -0.759404110925787 0.190391812236575 no 2751 0.223805427561734 850 772567
SGTC_1280 0880-0253 10.1 µM -0.760427548931685 0.190060043754142 no 2752 0.223499530622099 856 6836607
SGTC_1608 st001473 40.5 µM -0.760794627376034 0.189941134352107 no 2753 0.223389871965341 866 7292267
SGTC_3074 9116018 49.47 µM -0.76126940371399 0.189787405724565 no 2754 0.223248085746201 901 17027303
SGTC_1233 0325-0408 14.2 µM -0.761814971619511 0.189610849882472 no 2755 0.22308522174723 856 12874
SGTC_1693 xanthone 101.9 µM -0.762034671895385 0.18953977936606 no 2756 0.223019655503644 875 7020 An insecticide.
SGTC_1579 chlormadinone acetate 49.4 µM -0.764859816255371 0.188627338719846 no 2757 0.222177512174847 859 45114258 A steroidal progestin.
SGTC_3117 9124945 49.47 µM -0.767210688050422 0.187870142455296 no 2758 0.221478129618918 843 17592065
SGTC_2715 st079500 56.4 µM -0.769808058033255 0.187035737066219 no 2759 0.220706879530025 854 28246688
SGTC_2389 9091542 195.52 µM -0.771064474484636 0.18663293713707 no 2760 0.220334358206136 848 3626624 YOL127W RPL25
SGTC_3196 9111891 49.47 µM -0.772373941688974 0.186213701502365 no 2761 0.219946491480863 879 18891510
SGTC_3220 9131269 49.47 µM -0.772593507341635 0.186143463105457 no 2762 0.219881494085197 876 17722206
SGTC_1447 4239-0816 81.9 µM -0.772985997651813 0.186017947545267 no 2763 0.219765333764383 851 1341554
SGTC_677 0929-0063 136 µM -0.774559291094759 0.185515346593597 no 2764 0.219300060076587 892 1539583
SGTC_2321 7390090 138.78 µM -0.775354737943536 0.185261555934023 no 2765 0.219065036390771 872 649046
SGTC_1108 betulinic acid 729.144 nM -0.776401265951042 0.184927985369083 no 2766 0.218756048707471 839 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.777121787674301 0.184698543196974 no 2767 0.21854346033153 866 2346 DNA damaging agent; causes G2/M arrest.
SGTC_778 3456-2434 196 µM -0.778239947842386 0.184342828084092 no 2768 0.218213785243845 820 5539063
SGTC_2779 methotrexate 400 µM -0.779172376254557 0.184046525111214 no 2769 0.217939090025009 866 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1310 1188-0297 994 nM -0.782095696306019 0.183119488938677 no 2770 0.217079167900976 844 1588352
SGTC_1627 st003713 25.6 µM -0.784341261516071 0.182409362514191 no 2771 0.216419947237002 881 16195070 YER133W GLC7
SGTC_1704 st028805 70.8 µM -0.784559669688702 0.182340386118098 no 2772 0.216355891995266 869 2876101
SGTC_223 busulfan 5 mM -0.784775521413027 0.182272233099238 no 2773 0.216292597297707 848 2478 A DNA alkylator.
SGTC_2628 lathosterol 100 µM -0.78484438186261 0.182250494452037 no 2774 0.216272407445272 859 6710616
SGTC_282 k297-0036 65.7 µM -0.785328421989114 0.182097732906805 no 2775 0.216130517894557 876 5061378
SGTC_2019 4016004 108 µM -0.786455033390975 0.181742487972573 no 2776 0.215800476465311 878 45595336
SGTC_2652 actinonin 100 µM -0.789648193690417 0.180737973531042 no 2777 0.21486662721045 867 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2193 5925765 200 µM -0.790275829129639 0.18054094009639 no 2778 0.21468334979104 876 877370
SGTC_1483 3453-0561 55.9 µM -0.791283140685064 0.1802249967766 no 2779 0.214389392176521 895 4546991
SGTC_962 1254-0300 21.5 µM -0.792613891489689 0.179808139109072 no 2780 0.214001406357549 842 7340576
SGTC_3227 9130768 49.47 µM -0.793792468009388 0.179439456206758 no 2781 0.213658129099495 884 17720899
SGTC_1900 st060200 72.8 µM -0.794399111656859 0.179249871031695 no 2782 0.213481560591849 874 688945
SGTC_607 4491-0986 66.8 µM -0.794435407450741 0.179238532050908 no 2783 0.213470999106365 847 698981 YDR232W HEM1
SGTC_1568 digitonin 820 nM -0.794817581231312 0.17911916650492 no 2784 0.213359811240058 885 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_3161 9100388 49.47 µM -0.795437717762491 0.178925583734653 no 2785 0.213179463453042 874 25236368
SGTC_2928 9011484 9.79 µM -0.795593647497414 0.178876929192637 no 2786 0.213134130040043 859 2994751
SGTC_1491 4138-0063 26.5 µM -0.797530937732973 0.178273133736522 no 2787 0.212571371217915 865 23883227
SGTC_1442 4112-3290 3 µM -0.798169991580719 0.178074241803775 no 2788 0.212385924519952 883 704353
SGTC_1051 3253-3903 78 µM -0.799375972516723 0.177699287130886 no 2789 0.212036219193316 864 5509239
SGTC_2255 7941087 197.44 µM -0.80098750181586 0.177199020553769 no 2790 0.211569440663948 866 935561
SGTC_2127 5253358 187.912 µM -0.800996455347646 0.177196243598604 no 2791 0.211566848960247 861 20612
SGTC_315 k915-0449 187 µM -0.801239564458913 0.177120853344072 no 2792 0.211496485310349 854 20970215 YNL149C PGA2
SGTC_208 k072-0098 12.366 µM -0.801358871911695 0.177083862476014 no 2793 0.21146195888282 887 5948901
SGTC_2855 9016525 58.44 µM -0.802222543901755 0.176816229487827 no 2794 0.211212118975594 874 43811474
SGTC_3085 9117376 49.47 µM -0.802495214889661 0.176731787864264 no 2795 0.211133277635806 866 16480349
SGTC_2269 7935389 174.42 µM -0.803799012085376 0.176328376266371 no 2796 0.210756530210195 859 97605
SGTC_1947 st076332 61.6 µM -0.804102963640151 0.176234413565932 no 2797 0.210668756572685 875 24208416
SGTC_1990 st072050 59.8 µM -0.804862639728804 0.175999708110867 no 2798 0.210449474849026 857 17233948
SGTC_3268 9137683 49.47 µM -0.806529872596702 0.175485302957638 no 2799 0.20996869534022 922 1953228
SGTC_729 4092-0585 94.1 µM -0.806646303451148 0.175449415216892 no 2800 0.209935144333569 868 2169061
SGTC_1886 st057356 49.9 µM -0.807941935920169 0.175050373520904 no 2801 0.209562004293186 870 24207747
SGTC_2378 9074213 121.43 µM -0.80842185341579 0.174902710039439 no 2802 0.209423887910706 868 657714
SGTC_565 1418-0001 44.5 µM -0.808882204051848 0.174761141291561 no 2803 0.209291453055809 888 2862145
SGTC_3247 9135149 49.47 µM -0.809056522751233 0.174707553145926 no 2804 0.209241317473565 882 8934436 YOR116C RPO31
SGTC_3158 9100007 49.47 µM -0.809527553608033 0.17456280348195 no 2805 0.209105880246062 888 19297233
SGTC_670 4204-0025 119 µM -0.810421548844092 0.174288284692252 no 2806 0.208848968528386 869 719039
SGTC_405 ebelactone b 50 µM -0.81185827463051 0.173847684836292 no 2807 0.208436479542972 875 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_759 3486-0358 89.3 µM -0.812343097092104 0.173699164609794 no 2808 0.208297393818366 885 875103
SGTC_2939 9044578 71.43 µM -0.812910991959655 0.173525298715704 no 2809 0.208134545954453 886 2653634
SGTC_1002 4049-0206 172 µM -0.814259395038621 0.173112917397135 no 2810 0.207748182980586 872 4662749
SGTC_1438 4092-1045 4 µM -0.814497252241161 0.173040238489429 no 2811 0.207680072851312 872 1351342
SGTC_2110 5483698 200 µM -0.814609938594409 0.173005813184344 no 2812 0.207647809852975 856 2848765 YHR062C RPP1
SGTC_525 k781-2675 26.7 µM -0.815962120787588 0.172593066382924 no 2813 0.207260900362112 854 3651118 YDL195W SEC31
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.820138008886509 0.171322365149341 no 2814 0.206068718261266 867 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_805 3852-0218 479 µM -0.822436849920489 0.170625398727854 no 2815 0.205414156954276 864 6615355
SGTC_1427 4048-4900 550 nM -0.82330134359777 0.170363770422168 no 2816 0.205168324881238 871 24132586
SGTC_1479 0549-0158 134 µM -0.823307646297497 0.170361863932164 no 2817 0.205166533253799 894 5440202
SGTC_2277 7947813 106.88 µM -0.823441158202812 0.170321481415683 no 2818 0.205128582877643 899 1246798
SGTC_7 0192-1582 4.227 µM -0.823832224887311 0.170203233193073 no 2819 0.205017447301916 894 252616
SGTC_2808 7946468 45.46 µM -0.824536771933662 0.169990329585159 no 2820 0.2048173154267 902 2970879
SGTC_646 4092-0839 27.3 µM -0.824564921640714 0.169981826711715 no 2821 0.204809321705647 881 877796
SGTC_1588 farnesol 29.9 µM -0.825031946257274 0.169840797490018 no 2822 0.204676726992806 867 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.827000680349474 0.169247116327035 no 2823 0.204118337930913 908 4620898
SGTC_12 0849-0099 9.267 µM -0.829029182745258 0.168636807034377 no 2824 0.203543947066423 879 6071388
SGTC_2526 patulin 37.61 µM -0.829042398663685 0.168632835445429 no 2825 0.203540208009799 891 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1456 k015-0012 13 µM -0.829535068018968 0.168484823542415 no 2826 0.203400850891872 882 2989616
SGTC_347 4534-1311 26.2 µM -0.829758837187699 0.168417624506307 no 2827 0.203337574047346 885 2862016
SGTC_2351 9026858 72.31 µM -0.83362904879451 0.167258107573012 no 2828 0.202245025535652 922 1409300
SGTC_755 1995-0008 37.3 µM -0.835031672796722 0.166839154235211 no 2829 0.201849937776606 865 689533
SGTC_2420 aureobasidin a 50 nM -0.835257035022691 0.16677190339606 no 2830 0.201786501402491 869 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1762 st045503 25.4615 µM -0.83651434710177 0.166397027164466 no 2831 0.201432804459441 886 4645554
SGTC_1065 prochlorperazine maleate 2.48 µM -0.845332402845364 0.163783167526461 no 2832 0.198962637198852 893 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1624 st003710 6.25 µM -0.846314892892545 0.163493595585632 no 2833 0.19868855094627 898 24207033
SGTC_3029 9088683 49.47 µM -0.846884614207346 0.163325832483252 no 2834 0.198529719554337 862 25236615
SGTC_2504 purpurogallin 52.29 µM -0.847995890134374 0.162998922328541 no 2835 0.19822012979015 873 5281571 An antioxidant.
SGTC_1768 st044301 37.178 µM -0.849339290458955 0.162604295191547 no 2836 0.197846261959567 923 3931349
SGTC_1727 st034309 9.9045 µM -0.849767291597622 0.162478699479426 no 2837 0.19772723893912 915 870305
SGTC_2414 st077232 92.9 µM -0.849849485196803 0.162454587230156 no 2838 0.197704386639584 865 729801
SGTC_2362 9071156 126 µM -0.85013295835519 0.162371445634637 no 2839 0.197625584798028 905 653133
SGTC_1157 4092-0394 27.6 µM -0.850689025726764 0.162208433661588 no 2840 0.197471060478122 891 3659885
SGTC_2546 rhodinyl acetate 100 µM -0.853184931579977 0.161478068160377 no 2841 0.196778379116692 881 6708682
SGTC_3154 9100113 49.47 µM -0.853191499825684 0.161476148957975 no 2842 0.196776558194299 893 25237525
SGTC_87 0100-0052 35.5 µM -0.855433124600608 0.160822028234143 no 2843 0.196155706103376 901 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1006 4099-6547 255 µM -0.856593596684426 0.16048407549599 no 2844 0.195834762895453 908 3146833
SGTC_2113 5491891 107.031 µM -0.856877947182593 0.160401337753439 no 2845 0.195756170810018 880 789979
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.857219761829735 0.160301916508549 no 2846 0.195661721459381 880 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_901 1112-0062 60.1 µM -0.857498275425328 0.160220936983625 no 2847 0.195584783752114 881 1908457
SGTC_2536 dehydroabietamide 32.04 µM -0.858133508747185 0.160036339089059 no 2848 0.195409373105456 890 3983547
SGTC_1226 3909-7979 35.4 µM -0.858765177983733 0.1598529148735 no 2849 0.195235041420138 890 6615510
SGTC_1478 0453-0656 35.7 µM -0.860291692974393 0.159410213162247 no 2850 0.194814135429692 900 5258496
SGTC_1986 st071812 45 µM -0.860369191702161 0.159387759334075 no 2851 0.194792781436604 899 11838594
SGTC_917 harmaline 728.087 nM -0.864768342719406 0.158116581538552 no 2852 0.193582974980738 866 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2366 9070441 60.58 µM -0.865035970394711 0.158039463219313 no 2853 0.1935095231124 890 6837235
SGTC_835 0312-0010 67.2 µM -0.866179824251773 0.157710134069436 no 2854 0.193195777861541 898 1626196
SGTC_2237 6667747 47.222 µM -0.866786853611777 0.157535546317023 no 2855 0.193029403251381 914 729940 YDL015C TSC13
SGTC_1248 0469-0687 58.6 µM -0.868923605627845 0.156922005650368 no 2856 0.19244445857316 900 4017482
SGTC_1473 k844-0725 134 µM -0.869282018264762 0.156819246274304 no 2857 0.192346447882964 889 54682906
SGTC_604 1000-0114 314 µM -0.869383607847651 0.156790127895964 no 2858 0.192318672984051 905 1572745
SGTC_3026 9090633 49.47 µM -0.87142319817872 0.156206277852731 no 2859 0.19176156191195 891 25236842
SGTC_1670 st016595 4.04 µM -0.871479463198392 0.156190191841495 no 2860 0.191746207224822 915 597879
SGTC_787 4152-0075 138 µM -0.873420922730768 0.155635802582224 no 2861 0.191216845459165 880 9566539
SGTC_2035 5154463 94.595 µM -0.878799421708493 0.154106743112978 no 2862 0.189755019948397 893 2769623
SGTC_3222 9128301 49.47 µM -0.880164667119766 0.153720202755647 no 2863 0.189385055618274 878 4911358
SGTC_727 3032-0951 202 µM -0.881004397297386 0.153482770000977 no 2864 0.189157719976369 903 3652836
SGTC_1511 0906-3109 28.5 µM -0.881667556770771 0.153295434156784 no 2865 0.188978305183306 893 2882180
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.88290613051074 0.152945955472739 no 2866 0.188643495519605 890 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1101 ebselen 5.29 µM -0.883196108072244 0.152864211141394 no 2867 0.188565162018108 885 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_382 3229-0966 23.2 µM -0.883276548431779 0.152841540233213 no 2868 0.188543435701005 903 5722370
SGTC_1719 st032227 49.2 µM -0.88387654199276 0.15267251139338 no 2869 0.188381430792961 891 3125804
SGTC_3078 9116413 49.47 µM -0.885276154821199 0.15227869779144 no 2870 0.18800385371903 896 17177322
SGTC_1895 st058434 18.3 µM -0.885991397195839 0.152077708321636 no 2871 0.187811081488293 937 5393175
SGTC_1293 1000-1278 195 µM -0.886664681914732 0.151888670377459 no 2872 0.187629729275878 907 678847
SGTC_693 4161-2696 114 µM -0.888085789555679 0.151490179126976 no 2873 0.187247302989334 922 805759
SGTC_1739 st037196 92.5 µM -0.889474318616651 0.151101495176913 no 2874 0.186874109622919 894 612214
SGTC_3286 9117135 37.221 µM -0.890166354271665 0.150908025102749 no 2875 0.186688283980831 884 3438150
SGTC_3189 9110682 49.47 µM -0.890274497301001 0.150877806823764 no 2876 0.186659255717293 916 17122418
SGTC_731 3966-0296 387 µM -0.893805108122411 0.149893464699695 no 2877 0.185713087826159 885 660956
SGTC_2786 7743617 45.45 µM -0.894672299764998 0.149652346401043 no 2878 0.185481145203697 901 583674
SGTC_2082 5219693 150 µM -0.894893727282014 0.149590821086339 no 2879 0.185421950122845 885 2834649
SGTC_2710 st078562 53.7235 µM -0.895129944447865 0.14952520496577 no 2880 0.185358814197376 910 17250908
SGTC_3157 9099274 49.47 µM -0.895866894044337 0.149320619450628 no 2881 0.185161928714879 871 17217662
SGTC_1156 4092-0367 4.88 µM -0.896261362784608 0.149211187308696 no 2882 0.185056594751885 902 1357585
SGTC_3066 9117245 49.47 µM -0.896613197225413 0.149113627822614 no 2883 0.18496267673005 883 17176980
SGTC_1086 cerivastatin 2.18 µM -0.8976037024178 0.148839201420466 no 2884 0.184698432237753 868 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_292 k038-0015 474 µM -0.898074123685935 0.148708986196374 no 2885 0.184573016676109 905 46368540
SGTC_2011 4012611 177 µM -0.898279361909927 0.148652198979757 no 2886 0.184518316216677 917 2049887
SGTC_2658 polymyxin b sulfate 77.05 µM -0.900069015596189 0.148157635370502 no 2887 0.184041761884936 907 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2982 9019404 25.97 µM -0.90054778899667 0.148025515146547 no 2888 0.183914402706296 888 22333232
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.900679582705673 0.147989159773605 no 2889 0.183879353714419 893 2724278 An inhibitor of dopamine biosynthesis.
SGTC_3077 9117319 49.47 µM -0.901516221544336 0.147758511853049 no 2890 0.183656956457335 909 17154678
SGTC_579 4491-1009 110 µM -0.901946464714101 0.147639994480328 no 2891 0.183542653514427 936 1271041
SGTC_574 1315-0397 40 µM -0.904232361100003 0.14701137574405 no 2892 0.18293610197658 918 6794277
SGTC_2177 5811945 192 µM -0.905111619974343 0.146770059284027 no 2893 0.182703128381782 898 5343475
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.905345948801373 0.146705791584147 no 2894 0.182641070516363 882 688669
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.906012918454592 0.146522969936749 no 2895 0.182464507403455 889 6708739 YPR165W RHO1
SGTC_726 3448-4391 34.2 µM -0.908053650739846 0.145964539205484 no 2896 0.181924938371397 898 1356692
SGTC_1866 st057638 64 µM -0.90809523262489 0.145953175527896 no 2897 0.181913954516174 879 688802
SGTC_2846 9008642 19.48 µM -0.908347804774407 0.145884164289057 no 2898 0.181847246491784 925 2992898
SGTC_2664 lyso-paf C-16 73.48 µM -0.908851346067151 0.145746645255179 no 2899 0.181714299486683 902 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2282 7944268 200 µM -0.909078534982816 0.145684627638624 no 2900 0.181654336065232 918 2970414
SGTC_1573 oleylamine 1.06 µM -0.911888641834358 0.144918996692489 no 2901 0.180913670632754 911 5356789 An amine of the fatty acid oleic acid.
SGTC_830 4076-0286 57.8 µM -0.911914548823755 0.144911950799225 no 2902 0.180906851092895 897 6866659
SGTC_1416 3966-0321 25.3 µM -0.912569461875104 0.144733911480648 no 2903 0.180734510759139 901 582530 YLR208W SEC13
SGTC_2210 7115885 190.385 µM -0.913814909056641 0.144395740991845 no 2904 0.180407055511067 915 2927039
SGTC_1724 st037281 8.293 µM -0.91529456845714 0.143994668582044 no 2905 0.180018504885267 888 574124 YDL195W SEC31
SGTC_1954 st077032 68.9 µM -0.915633250344637 0.14390297217082 no 2906 0.179929642791198 920 698907
SGTC_184 1494-0393 24.714 µM -0.916897172707299 0.143561119410721 no 2907 0.179598262829332 909 3090647
SGTC_2089 5281248 129.67 µM -0.917208498225791 0.143476999485015 no 2908 0.17951669723274 903 2737878
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.919748560945952 0.142791919782901 no 2909 0.178852084793398 885 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3023 9089636 49.47 µM -0.921806683271506 0.142238448341642 no 2910 0.178314710382304 931 17249241
SGTC_728 3030-5151 22.5 µM -0.922740889318296 0.141987700753884 no 2911 0.178071125855815 908 3125388
SGTC_270 tamoxifen 5.46 µM -0.924079607771292 0.141628901100127 no 2912 0.177722434811879 929 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1505 k297-0037 20.6 µM -0.925226926414617 0.141321889081447 no 2913 0.177423940012227 896 4089396
SGTC_3072 9116419 49.47 µM -0.927650292374424 0.140674902062583 no 2914 0.176794500393876 913 17170162
SGTC_1176 0848-0131 83.3 µM -0.930775038764577 0.139843632734301 no 2915 0.175984972098995 924 6769040
SGTC_3098 9119039 49.47 µM -0.934987897218077 0.138728190295431 no 2916 0.174897268331244 900 17161528
SGTC_1733 st037357 54.9 µM -0.935748039115571 0.138527573990506 no 2917 0.174701465151655 926 1272339 YGL099W LSG1
SGTC_676 falcarinol 140 µM -0.937377940439998 0.138098077801296 no 2918 0.174282092003876 911 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1126 isoteolin 1.0172 µM -0.937665088286039 0.138022505499608 no 2919 0.174208275274033 892 133323
SGTC_1413 3910-0535 34.4 µM -0.938190391340773 0.137884327912039 no 2920 0.174073287719436 901 2876951
SGTC_1216 1165-0504 9.65 µM -0.939682002824846 0.137492483678714 no 2921 0.173690349675023 921 6304004
SGTC_205 1486-1330 71.903 µM -0.940433888717248 0.137295252780087 no 2922 0.173497523031155 920 4118834
SGTC_578 3460-0051 92 µM -0.941506444459547 0.137014239943407 no 2923 0.173222694148879 936 2876744
SGTC_2290 7904846 200 µM -0.941552078333349 0.13700229245383 no 2924 0.173211007196024 911 2962154
SGTC_3102 9121669 49.47 µM -0.942183854573835 0.136836959089042 no 2925 0.173049259269643 931 41905072
SGTC_1336 1486-0901 104 µM -0.943063981839457 0.136606860652203 no 2926 0.172824088733247 897 5006114
SGTC_1147 3809-1045 12.3 µM -0.944723459800957 0.136173730670059 no 2927 0.172400038413412 898 325925
SGTC_925 2064-1272 59.6 µM -0.948385251157996 0.135221317215084 no 2928 0.171466682515811 935 6815817
SGTC_1355 1499-0035 1.68 µM -0.950569011740441 0.134655511006335 no 2929 0.170911602795803 940 1548538
SGTC_2219 9098279 200 µM -0.951762946324397 0.13434685389273 no 2930 0.170608608916057 891 902349
SGTC_1836 st055642 81 µM -0.951772343092599 0.134344426559685 no 2931 0.170606225591314 919 8571
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.952775299880297 0.134085520180947 no 2932 0.170351965823757 919 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2517 totarol 10 µM -0.955098790226904 0.1334870447548 no 2933 0.169763870354485 908 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2673 kobusone 100 µM -0.956133138745807 0.133221213238994 no 2934 0.169502487140238 952 6710676 An epoxy ketone and protein crosslinker.
SGTC_2056 5235370 200 µM -0.957278767764656 0.132927207646072 no 2935 0.169213284549583 931 5511916
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.958259249293731 0.132675939275124 no 2936 0.168966023531057 934 688751
SGTC_1843 st055809 45.5 µM -0.958842927215208 0.132526515358882 no 2937 0.168818939995036 932 16413835
SGTC_2198 6589944 200 µM -0.959854400950997 0.132267848629636 no 2938 0.1685642492042 905 5290268
SGTC_2649 anisomycin 9.56 µM -0.960880870084534 0.132005703100918 no 2939 0.16830603522134 923 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1847 st056231 15 µM -0.960982618737946 0.131979737483661 no 2940 0.168280453651912 904 5393180
SGTC_1676 st018489 23.4 µM -0.961750649285717 0.131783854559352 no 2941 0.168087436690011 905 3696235
SGTC_2867 9039098 71.43 µM -0.962736053341435 0.131532825349704 no 2942 0.167839999419814 906 6463460
SGTC_874 0599-0792 117 µM -0.965066997496727 0.130940337594764 no 2943 0.167255627834486 913 765305
SGTC_2363 9053361 176 µM -0.968901960418364 0.129969571002448 no 2944 0.1662970536259 924 6469797 YMR079W SEC14
SGTC_2336 9001819 198.65 µM -0.970427126057047 0.129584885060772 no 2945 0.165916816491315 905 2989602
SGTC_2043 5101342 149 µM -0.971774496271176 0.129245700473119 no 2946 0.165581373154006 935 678451
SGTC_3163 9099914 49.47 µM -0.972421720229934 0.129082988454775 no 2947 0.165420395351321 947 16268368
SGTC_2981 9013952 38.96 µM -0.976475475375688 0.128067105731586 no 2948 0.164414447688403 918 2996344
SGTC_1845 st056753 3.01 µM -0.977464054815588 0.127820209490745 no 2949 0.164169732385119 917 5375839
SGTC_959 1222-0044 107 µM -0.978512904262077 0.127558622768399 no 2950 0.163910356109543 904 6083612
SGTC_2733 amorolfine 100 µM -0.980163101020398 0.127147811849607 no 2951 0.163502807665094 968 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_263 alizarin 107.927 µM -0.981886940716964 0.126719651849674 no 2952 0.16307777506171 945 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.983116745492191 0.126414812432343 no 2953 0.162774991798931 928 368090
SGTC_918 glabranin 770.725 nM -0.98385415117314 0.126232272287082 no 2954 0.162593614780016 931 124049 Also referred to as licorice root.
SGTC_114 0364-0001 490.298 µM -0.983918537541776 0.126216342570861 no 2955 0.162577784140991 934 4003655
SGTC_857 0438-0306 1.35 µM -0.984207949734298 0.126144756921677 no 2956 0.162506638918406 902 4686136
SGTC_2029 5175081 200 µM -0.98736252851151 0.125366312090185 no 2957 0.161732473598248 918 1380876
SGTC_2268 7933382 153.85 µM -0.992501983406758 0.124105259926405 no 2958 0.160476356202807 925 935025 YOR257W CDC31
SGTC_1650 st011916 45.8 µM -0.994979495905548 0.123500541259435 no 2959 0.159873118423693 952 242528
SGTC_972 1319-0219 195 µM -0.995067675545462 0.123479056210547 no 2960 0.159851675352002 936 23903702
SGTC_2102 5377816 72.7585 µM -0.996159480280068 0.123213253874364 no 2961 0.159586331750926 919 1379702
SGTC_19 0279-0214 38.434 µM -0.996331992951311 0.123171291984434 no 2962 0.159544432021337 932 3566274 YBR002C RER2
SGTC_2729 fluphenazine 10.66 µM -0.998840608939683 0.122562229122774 no 2963 0.158935955253314 915 3372 An atypical antipsychotic.
SGTC_1500 4488-1866 171 µM -0.999962933012011 0.122290427128121 no 2964 0.158664223223626 945 2900003
SGTC_409 arachidonic acid 100 µM -1.00049159054391 0.122162544698819 no 2965 0.158536332648855 932 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1863 st057641 20.1 µM -1.00164420029215 0.121884053621126 no 2966 0.158257732666538 948 3921635
SGTC_1723 st034307 2.5525 µM -1.00690906565174 0.12061764028578 no 2967 0.156989237523106 916 867466
SGTC_2962 9082311 13.18 µM -1.00759837326643 0.120452522286916 no 2968 0.156823655103217 929 16459453
SGTC_2885 9057732 51.95 µM -1.00835403631158 0.120271692376526 no 2969 0.156642265173517 922 6471414
SGTC_2001 4023502 57.655 µM -1.00933853537203 0.120036389102395 no 2970 0.156406152529332 918 108941 YCR052W RSC6
SGTC_432 NS 1619 61.3 µM -1.01277790242476 0.119216899810777 no 2971 0.155583128947396 916 4552 A K+/calcium channel activator.
SGTC_1304 1165-0502 251 µM -1.01305629215302 0.119150741767609 no 2972 0.155516636858536 923 767425
SGTC_2947 9072639 7.68 µM -1.01381462426187 0.118970659083258 no 2973 0.155335607869027 971 16488146
SGTC_1017 4239-0030 168 µM -1.01467056809154 0.118767627340139 no 2974 0.15513144415328 912 1149593
SGTC_580 1123-0028 41 µM -1.01694673736035 0.118228906269656 no 2975 0.154589383973619 964 1677248 YPR107C YTH1
SGTC_2513 baicalein 25.65 µM -1.01707915602238 0.118197618845926 no 2976 0.154557887600964 954 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3281 9140613 49.47 µM -1.01798720732516 0.117983225353156 no 2977 0.154342017798845 913 16013766
SGTC_817 1391-0715 46 µM -1.02205764211965 0.117025564862797 no 2978 0.153376809701418 938 1353946
SGTC_3050 9093513 49.47 µM -1.02341092071529 0.116708399344108 no 2979 0.153056799049769 911 25236664
SGTC_1117 retinoic acid 1.10837 µM -1.02423060877659 0.116516587130852 no 2980 0.152863182269927 962 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1343 1487-0095 224 µM -1.02460238901144 0.116429661938945 no 2981 0.152775418409922 941 4560101 YGL055W OLE1
SGTC_806 3966-4455 5.86 µM -1.02473966104711 0.116397578270509 no 2982 0.152743021898953 938 714982
SGTC_559 1550-0661 158 µM -1.02718500448677 0.115827095364704 no 2983 0.152166678890677 935 5830875
SGTC_2161 5662504 8.5105 µM -1.02741135155714 0.115774390622316 no 2984 0.152113404261122 903 2859334
SGTC_1397 3532-0190 20.1 µM -1.02746064762063 0.115762914330596 no 2985 0.152101803237587 902 5322280
SGTC_343 4130-2827 29.8 µM -1.03072392802583 0.11500500772508 no 2986 0.151335150264234 937 1118244
SGTC_2477 5967686 25.23 µM -1.03289672981345 0.114502329110393 no 2987 0.150826114660671 953 776118
SGTC_1671 st016596 74.5 µM -1.03330872908107 0.114407189566228 no 2988 0.150729721773517 939 2829167
SGTC_2031 5180455 200 µM -1.0333187802117 0.114404869246161 no 2989 0.150727370686132 970 29949
SGTC_2951 9072950 58.06 µM -1.03403337295316 0.114239990188553 no 2990 0.150560280928203 933 16488155
SGTC_1231 0242-0792 125 µM -1.03453564620004 0.114124201243919 no 2991 0.150442910670677 943 3707635
SGTC_599 1935-0052 86.5 µM -1.03508309466666 0.113998093301651 no 2992 0.150315053398141 936 9557311
SGTC_2645 abamectin 100 µM -1.03633103053606 0.113710995187236 no 2993 0.150023867155168 885 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1939 st074455 53.6 µM -1.03642115248213 0.113690281849428 no 2994 0.150002853184744 933 1644229
SGTC_2700 st077718 96.8 µM -1.03882903429084 0.113137857673547 no 2995 0.149442127791505 941 904970
SGTC_3140 9094243 49.47 µM -1.03948567477613 0.112987541977766 no 2996 0.149289458494186 950 19291112
SGTC_842 0271-0008 11.1 µM -1.04083920038601 0.112678147779713 no 2997 0.148975091663421 922 1221709
SGTC_2489 cantharidin 73.42 µM -1.04440796293348 0.111865287888172 no 2998 0.148148340519243 927 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2479 5617353 43.85 µM -1.04902006496881 0.110821009351623 no 2999 0.147084441835783 920 2731746
SGTC_3000 9075062 71.4286 µM -1.04917827761212 0.110785310951092 no 3000 0.147048037171602 899 17057871
SGTC_359 0081-0058 15.9 µM -1.05032373615745 0.110527100513345 no 3001 0.146784647863602 923 3494159
SGTC_1218 1348-1416 30.7 µM -1.0504047178666 0.110508861875265 no 3002 0.146766038734386 929 6787668
SGTC_2195 6536160 144.242 µM -1.05091216485881 0.110394624171416 no 3003 0.146649466380418 933 3834386
SGTC_1227 3909-8010 46.6 µM -1.05274875263407 0.109981874913229 no 3004 0.146228079029656 941 15982272
SGTC_1530 rhein 70.4 µM -1.05385635342611 0.109733491904621 no 3005 0.145974344174448 936 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_3171 9103192 49.47 µM -1.05549467706994 0.109366831338555 no 3006 0.145599571332441 960 13018434
SGTC_2158 5657123 3.6195 µM -1.05575514180145 0.109308619910572 no 3007 0.145540048679799 968 2858827
SGTC_1761 st044296 37 µM -1.05728670293774 0.10896678055177 no 3008 0.145190379994352 945 1826700
SGTC_2803 7707263 71.43 µM -1.0580999609501 0.108785576734415 no 3009 0.145004936115679 945 2199229
SGTC_1285 0929-0069 65.5 µM -1.05913445331779 0.108555392437858 no 3010 0.144769275571856 944 1206237
SGTC_1016 4226-1401 38 µM -1.05957657494686 0.108457123151615 no 3011 0.144668637620334 933 2901613
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.06090137761095 0.108163045789065 no 3012 0.144367361578488 922 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1966 st070145 16.1 µM -1.062211824998 0.107872720110243 no 3013 0.144069766388037 951 3748532
SGTC_350 k064-0020 19.8 µM -1.06291668976114 0.107716791770183 no 3014 0.143909866802469 906 2790705
SGTC_1094 duloxetine 25.4 µM -1.0631679416548 0.107661249757337 no 3015 0.143852898900781 933 60834 A selective serotonin reuptake inhibitor.
SGTC_1377 2944-0135 198 µM -1.06809383822355 0.10657649084978 no 3016 0.142739092532766 920 1894137
SGTC_520 3584-0023 682 µM -1.07563275318003 0.104931618172718 no 3017 0.141045766564039 939 1340790
SGTC_2142 5622915 118.518 µM -1.07853923662308 0.104302402990619 no 3018 0.140396590741157 943 5322196
SGTC_1250 0485-0349 40.2 µM -1.08048764050407 0.103882133146431 no 3019 0.139962543814258 951 6842794 YDL195W SEC31
SGTC_3006 9075424 71.4286 µM -1.08058891098228 0.103860322776142 no 3020 0.139940008695555 947 7465181
SGTC_659 k018-0002 107 µM -1.08060954271186 0.103855879779286 no 3021 0.13993541794154 958 6797879 YHR007C ERG11
SGTC_816 0325-0417 81.3 µM -1.08591625167042 0.102717665310891 no 3022 0.138758023049332 935 68101
SGTC_1849 st056239 19.2 µM -1.08613381742642 0.102671194747341 no 3023 0.138709896335188 932 5393181
SGTC_1645 Cervolide 78 µM -1.09027676096537 0.101789204343356 no 3024 0.137795624411483 956 23173 A fragrance.
SGTC_408 cantharidin 100 µM -1.09385378337502 0.101032140478214 no 3025 0.137009555631998 937 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3153 9100258 49.47 µM -1.09590138821756 0.100600623781435 no 3026 0.136560965754516 955 25236848
SGTC_2657 nystatin 74.44 µM -1.09732355366965 0.100301705727498 no 3027 0.136249989056487 940 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3204 9114183 49.47 µM -1.10089352212145 0.0995542084573625 no 3028 0.135471500862613 935 17027248
SGTC_2496 diffractaic acid 79.83 µM -1.10424801805284 0.0988555454334924 no 3029 0.134742782582338 956 94870 An apoptosis inducer which activates caspases.
SGTC_1134 3477-0009 42.5 µM -1.10700389146875 0.098284251287234 no 3030 0.13414612292539 918 3973534
SGTC_509 pifithrin 175 µM -1.11178607357546 0.0972986474629822 no 3031 0.133115070530662 987 4817 A p53 inhibitor.
SGTC_329 k048-0121 21.3 µM -1.11812619089464 0.0960031607819423 no 3032 0.131756550956446 966 6832902
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.11930361667991 0.0957639784038842 no 3033 0.1315053167092 947 688803
SGTC_944 3370-0224 231 µM -1.12061816340034 0.095497459521249 no 3034 0.131225215087101 960 4580514
SGTC_732 3970-1727 52.7 µM -1.12226635835469 0.0951640667058893 no 3035 0.130874602762506 970 1275699
SGTC_3311 9131146 2.8755 µM -1.12815987909264 0.0939789518915295 no 3036 0.129626202254806 960 4900406 YPR165W RHO1
SGTC_3259 9138485 49.47 µM -1.12942561876764 0.0937258539826199 no 3037 0.129359165340765 949 17646153
SGTC_2218 6965428 192.983 µM -1.13088986498699 0.0934336908217458 no 3038 0.129050724798271 949 675684
SGTC_16 erodoxin 22.806 µM -1.13125701265527 0.093360538915276 no 3039 0.12897346590446 966 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1444 4112-3581 28 µM -1.13237318173732 0.0931384089574582 no 3040 0.128738787423097 953 2877249
SGTC_3011 9081274 71.4286 µM -1.13295992503922 0.0930217973103302 no 3041 0.128615541451282 968 6625322
SGTC_3307 9126885 69.2785 µM -1.13315513575213 0.0929830243090808 no 3042 0.128574555418787 965 24824909
SGTC_2914 7968218 45.32 µM -1.13464607918328 0.0926872852169956 no 3043 0.128261819046902 936 2977111
SGTC_1029 k015-0030 64.7 µM -1.13777841559436 0.0920682314554637 no 3044 0.127606510025696 954 2208316
SGTC_1662 st014054 52 µM -1.13981957048182 0.0916664820968048 no 3045 0.127180739302461 971 2838777
SGTC_558 k064-0027 21.3 µM -1.14280774782725 0.0910806802775949 no 3046 0.126559210631268 938 5088526
SGTC_1694 st024011 44.9 µM -1.14296782946188 0.0910493764367998 no 3047 0.126525974116301 970 2787533
SGTC_2929 9013348 24.6 µM -1.14534054512218 0.0905863290198553 no 3048 0.126034058316354 967 2995952
SGTC_2797 7859098 81.82 µM -1.14928489013976 0.0898204422577401 no 3049 0.125219263252007 937 972681
SGTC_708 3448-5400 146 µM -1.14997211752543 0.0896874948134932 no 3050 0.125077677741984 972 3462195
SGTC_1440 4100-1550 40 µM -1.15076089823358 0.0895350817836371 no 3051 0.12491530764649 974 742806
SGTC_1113 artemisinin 1.17947 µM -1.15210391435756 0.0892760193119942 no 3052 0.124639187412697 951 2240 An anti-malaria and mitochondrial poison.
SGTC_1289 0976-0073 69.1 µM -1.15351321015271 0.0890047718441193 no 3053 0.124349899298639 971 3391136
SGTC_2070 5230947 200 µM -1.1542086382006 0.0888711489146222 no 3054 0.124207320971971 978 2835538
SGTC_1353 1498-1206 8.11 µM -1.15685806207657 0.0883634440363239 no 3055 0.12366517765266 893 6756808
SGTC_556 4058-0063 51.5 µM -1.15763604426881 0.0882147718497562 no 3056 0.123506296772656 973 6615692
SGTC_905 2-aminofluorene 215 µM -1.16417087325959 0.0869733212084077 no 3057 0.122177385727659 968 1539 An established DNA mutagen. YPR165W RHO1
SGTC_423 5-fluorouracil 457 µM -1.16600875686152 0.0866265327789934 no 3058 0.121805452496967 942 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2473 5854593 8.94 µM -1.16869116903961 0.0861222475797706 no 3059 0.121264040604717 961 2872951
SGTC_1334 1486-0610 236 µM -1.1690467932154 0.086055556550387 no 3060 0.121192389497417 944 3742339
SGTC_2320 7373003 200 µM -1.16922717302098 0.0860217442788008 no 3061 0.121156057984703 953 5415828
SGTC_1232 0279-0259 161 µM -1.16934782626058 0.0859991333263164 no 3062 0.121131760678665 955 1560000
SGTC_1801 st050089 28.441 µM -1.16937759189143 0.0859935557989688 no 3063 0.121125766964417 961 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1816 st051957 91.6 µM -1.17045353619387 0.085792125465156 no 3064 0.120909251007889 995 674121
SGTC_622 1348-1566 26.3 µM -1.17084931266735 0.085718120038549 no 3065 0.120829676110679 956 7340407
SGTC_3035 9091303 49.47 µM -1.17095808250349 0.0856977897654597 no 3066 0.120807813283902 991 25237002
SGTC_55 0767-0285 6.563 µM -1.17384133495383 0.0851601935789518 no 3067 0.120229292011873 960 3116166
SGTC_1087 pterostilbene 9.05 µM -1.17450922886016 0.0850360228441201 no 3068 0.120095558779087 983 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2342 7990637 118.86 µM -1.17852210349796 0.0842928293908313 no 3069 0.119294262873589 1001 2033102 YER133W GLC7
SGTC_125 0133-0007 11.75 µM -1.18194546027797 0.0836626780181466 no 3070 0.118613671129241 961 26541
SGTC_2395 5646831 180.19 µM -1.18211833458725 0.0836309504634861 no 3071 0.118579375203691 992 6808628
SGTC_1167 k781-0610 148 µM -1.18342268654209 0.0833918546245006 no 3072 0.118320835295738 959 4525169
SGTC_971 1315-0384 26.7 µM -1.18378066956909 0.0833263240493491 no 3073 0.118249948046387 989 6769120
SGTC_1497 4476-2978 41.3 µM -1.18406412164277 0.0832744642025754 no 3074 0.118193840607438 943 1528379
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.18406514074309 0.0832742777937255 no 3075 0.118193638917326 973 165521
SGTC_334 1502-1024 68.5 µM -1.1864215834834 0.0828440872911487 no 3076 0.117727926136386 976 3296216
SGTC_1020 4335-0961 93.3 µM -1.18657108107738 0.0828168516254171 no 3077 0.117698424226805 989 669075
SGTC_2460 5552655 174.22 µM -1.18678204836475 0.0827784287934752 no 3078 0.117656800768154 966 5401989
SGTC_1862 st057513 3.81 µM -1.18940211375668 0.0823023613755727 no 3079 0.117140734727439 972 5393163
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.18951410906737 0.0822820578090297 no 3080 0.117118711159077 953 6708514
SGTC_484 loperamide 105 µM -1.19027398165904 0.0821444005457408 no 3081 0.116969361787953 956 3955 An opioid-receptor agonist.
SGTC_166 k072-0058 166.424 µM -1.19640410534443 0.0810402158874959 no 3082 0.11576945002742 966 5846229
SGTC_871 0574-0004 149 µM -1.19745989945997 0.0808511777588763 no 3083 0.11556367430355 985 9551173
SGTC_979 1426-2828 121 µM -1.19765255317514 0.0808167193863027 no 3084 0.11552615388178 989 747872
SGTC_808 0711-0032 135 µM -1.19776554132911 0.0807965152912372 no 3085 0.115504152814449 963 4252555
SGTC_232 clozapine 119 µM -1.19897036405638 0.0805813107528333 no 3086 0.115269734699023 968 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2937 9044753 11.33 µM -1.2021960680507 0.0800072694486002 no 3087 0.114643786181683 935 6465530 YGL099W LSG1
SGTC_2688 kanamycin b 96.69 µM -1.20514984915842 0.0794843359523985 no 3088 0.114072729373087 949 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2617 dihydrotanshinone i 20.83 µM -1.20530273917319 0.0794573390808617 no 3089 0.114043226281354 961 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1721 st082152 9.2685 µM -1.20580080656684 0.0793694399233445 no 3090 0.113947152223559 971 5296051
SGTC_2475 5812728 15.03 µM -1.20884088047741 0.0788345212725638 no 3091 0.11336199127203 963 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_3169 9102970 49.47 µM -1.20890793237004 0.0788227539647502 no 3092 0.113349109160599 1007 17027839
SGTC_1178 0988-0033 191 µM -1.2091132872317 0.0787867233822066 no 3093 0.113309662568612 958 5392207
SGTC_93 0109-0045 59.227 µM -1.21041741913313 0.0785581978430985 no 3094 0.113059380568264 986 88733
SGTC_2398 5228213 48.84 µM -1.21172694147252 0.0783292336378765 no 3095 0.112808461284077 984 80771 YMR134W ERG29
SGTC_1295 1013-0063 9.78 µM -1.2146657450556 0.0778172393467153 no 3096 0.112246801227178 988 6826038
SGTC_3351 9150312 21.596 µM -1.21730056477958 0.0773603677771055 no 3097 0.111744939754181 978 4904905
SGTC_2639 lactacystin 53 µM -1.21769229024639 0.0772926178288275 no 3098 0.111670463975881 951 3870 A proteasome inhibitor.
SGTC_472 calcifediol 10 µM -1.21778374389902 0.0772768071712211 no 3099 0.11165308170376 996 5283731 A vitamin D metabolite.
SGTC_534 k292-0788 63.4 µM -1.21969246678704 0.0769473845162132 no 3100 0.111290739199767 975 4146317
SGTC_69 0096-0274 206.684 µM -1.22091904312581 0.0767362562294816 no 3101 0.111058336757787 983 6741392
SGTC_2168 5727979 200 µM -1.22424345433235 0.0761662465089049 no 3102 0.110430200511014 988 695210
SGTC_3184 9108758 49.47 µM -1.22574054832406 0.0759106068954289 no 3103 0.110148163027872 986 902885
SGTC_2837 9008476 45.46 µM -1.22603731962908 0.0758600087376441 no 3104 0.110092315712554 974 2992805
SGTC_214 4373-3496 70 µM -1.22740339896797 0.0756274296003597 no 3105 0.109835504763936 989 3779166
SGTC_10 0279-0212 42.575 µM -1.22846630894137 0.0754468420662069 no 3106 0.10963598462633 997 39851 YBR002C RER2
SGTC_407 eburnamonine 100 µM -1.22982191885067 0.0752170021253921 no 3107 0.109381899175978 962 3195
SGTC_2140 5586273 200 µM -1.23081716745363 0.0750486005665859 no 3108 0.109195626619779 977 854421
SGTC_2936 9038235 15.59 µM -1.23181122824322 0.0748806871685953 no 3109 0.109009804007273 962 4749415
SGTC_2778 tioconazole 65.09 nM -1.23291528709774 0.0746945293595645 no 3110 0.108803685675618 956 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.23479770035054 0.0743779461845974 no 3111 0.108452901728687 974 688662
SGTC_978 1416-0512 87.4 µM -1.23655993020383 0.0740825048275353 no 3112 0.108125251810457 1000 6814003
SGTC_1865 st057639 52.2 µM -1.23975555384793 0.0735490401782688 no 3113 0.107532911132985 985 688818
SGTC_1221 2958-7315 257 µM -1.23981375108817 0.0735393522691887 no 3114 0.10752214541947 982 4562705
SGTC_2972 9093619 59.92 µM -1.23983842964817 0.0735352444025982 no 3115 0.107517580449435 959 25236256
SGTC_473 2-arachidonoylglycerol 10 µM -1.24143123639984 0.0732704849026884 no 3116 0.107223242933886 947 5282280 An endocannabinoid.
SGTC_829 1635-0120 117 µM -1.24164685861989 0.0732346998620907 no 3117 0.107183442422553 965 285054
SGTC_1519 esterone 74 µM -1.2517792963345 0.0715681362220749 no 3118 0.105325148127071 993 698 A steroid.
SGTC_2713 st079149 53.4 µM -1.25639117540748 0.0708192881340611 no 3119 0.10448708976217 978 3103253
SGTC_2452 5863136 48.41 µM -1.25659252141325 0.0707867325003979 no 3120 0.104450612086972 978 2184096
SGTC_1210 3013-0140 750 nM -1.25663762069755 0.0707794419740716 no 3121 0.104442442755113 983 905973
SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.25835201401948 0.0705027292607439 no 3122 0.104132238961881 969 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1345 1488-0192 31.4 µM -1.26214063013683 0.0698941755776597 no 3123 0.103449093703946 987 658348
SGTC_589 1227-0070 34.1 µM -1.26352937257157 0.0696721213947234 no 3124 0.103199498782961 986 2841384
SGTC_2117 5521686 200 µM -1.26433216200443 0.0695440066213058 no 3125 0.103055415217844 995 803312
SGTC_341 1486-1430 230 µM -1.26514281736427 0.0694148207002342 no 3126 0.102910068211432 993 2054753 YPL210C SRP72
SGTC_621 3584-0052 32.1 µM -1.26767565491841 0.0690123788158643 no 3127 0.102456901095118 980 2273927
SGTC_1637 st007924 17.4 µM -1.2698852232584 0.0686627718500533 no 3128 0.102062758743053 955 683336
SGTC_1850 st056238 17 µM -1.27020923605962 0.0686116202488257 no 3129 0.102005054280472 966 5393177
SGTC_777 1315-0167 517 µM -1.27022135918654 0.0686097069525476 no 3130 0.102002895695373 966 4221767
SGTC_44 0929-0055 61.211 µM -1.27085611026527 0.0685095867323621 no 3131 0.101889921429299 955 1379590
SGTC_736 0958-0254 92.6 µM -1.27229137444487 0.0682836159752158 no 3132 0.101634806068753 994 6812352
SGTC_159 3970-0959 50 µM -1.27536482022603 0.0678016617973508 no 3133 0.101090072224331 969 6615653
SGTC_1881 5652484 16 µM -1.27602424918758 0.0676985983661374 no 3134 0.100973473602296 989 2255129
SGTC_1272 0839-0021 27 µM -1.27657599856855 0.0676124574154119 no 3135 0.100875989979277 1003 5027250
SGTC_2853 9015042 58.44 µM -1.27911305706195 0.0672174529780701 no 3136 0.10042862313741 972 6457456
SGTC_3294 9122953 26.2835 µM -1.28218892156471 0.0667409553489466 no 3137 0.0998881907585626 998 16459826
SGTC_3332 9141069 11.198 µM -1.28304468804759 0.0666088501235811 no 3138 0.0997382101377694 974 17332883
SGTC_233 rapamycin 362 pM -1.28942136341181 0.0656308424578841 no 3139 0.0986258191563675 989 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1752 st044819 83.042 µM -1.29345104165904 0.0650185645885227 no 3140 0.0979275532405885 986 441209 YML126C ERG13
SGTC_2958 9077254 16.72 µM -1.29391907985602 0.0649477381949553 no 3141 0.0978466866420972 993 16457351
SGTC_956 1185-0240 191 µM -1.29500374575851 0.0647838301713558 no 3142 0.0976594686595809 987 1416193
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.29809589034497 0.0643183271420698 no 3143 0.0971271931700085 1037 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_427 1354-0053 47.3 µM -1.30050734492499 0.0639571050980428 no 3144 0.0967135702691114 1017 6813657
SGTC_575 k072-0246 11.9 µM -1.30095378681321 0.0638904040655568 no 3145 0.0966371367973463 1005 6796779
SGTC_788 1182-0090 188 µM -1.30563771533095 0.0631938550459548 no 3146 0.0958378940914882 987 5715185
SGTC_144 4161-2749 112.381 µM -1.30587605857186 0.0631585696521213 no 3147 0.0957973547552471 982 797501 YMR168C CEP3
SGTC_2293 7624732 200 µM -1.30856733693099 0.0627612047669143 no 3148 0.0953404755735303 977 894453
SGTC_673 1082-0474 110 µM -1.30957443274308 0.0626130098707152 no 3149 0.095169921184951 984 3098046
SGTC_1399 3562-5772 25 µM -1.31319072078159 0.0620831176920734 no 3150 0.0945593449842351 984 23847490
SGTC_74 000s-0487 160.283 µM -1.31726385765237 0.0614904806733328 no 3151 0.0938750977734206 991 677548
SGTC_1072 oxiconazole 14.9 nM -1.31776802556704 0.0614174331270965 no 3152 0.0937906573089977 981 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1864 st057645 30.4 µM -1.32087084310569 0.0609693654432141 no 3153 0.093272216563716 997 688666
SGTC_3113 9123498 49.47 µM -1.3255852987108 0.0602934625444971 no 3154 0.0924885492178279 1014 8897275
SGTC_337 1315-0038 354 µM -1.32635602792435 0.0601835244151431 no 3155 0.0923608982809803 990 1626437
SGTC_2732 terfenadine 20 µM -1.32710498951882 0.0600768416616099 no 3156 0.0922369775283451 1029 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2416 tofa 880 nM -1.32819128565852 0.0599223718754812 no 3157 0.0920574612542176 992 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2966 9084041 48.03 µM -1.32889254237838 0.0598228194933945 no 3158 0.0919417122936097 997 17741380
SGTC_1368 1852-0141 284 µM -1.32995945799228 0.0596716057104186 no 3159 0.0917658147091598 1006 2838987
SGTC_2801 7907800 81.82 µM -1.33103436982861 0.0595195616620477 no 3160 0.0915888510476325 983 6620925
SGTC_2445 5742597 35.57 µM -1.33198945187389 0.0593847221976495 no 3161 0.0914318273459816 992 1774255
SGTC_3122 9126309 49.47 µM -1.33417133977195 0.0590775795338853 no 3162 0.0910738549993484 1028 17591206
SGTC_1631 benzylvanillin 81.9 µM -1.33798427763413 0.0585438282574436 no 3163 0.0904507810251919 966 75506
SGTC_2739 tacrine 100.86 µM -1.33942994681642 0.0583424500422798 no 3164 0.090215372887259 930 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1767 st044992 70.3 µM -1.34858710759022 0.057079490586557 no 3165 0.0887348119983682 997 9600693
SGTC_451 chloral hydrate 100 µM -1.35045317960498 0.0568247805018949 no 3166 0.0884353312157134 1003 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_3099 9120367 49.47 µM -1.35103300294724 0.0567458198805437 no 3167 0.0883424304856989 1012 24824940
SGTC_757 1066-0008 322 µM -1.35623129085075 0.0560417696014104 no 3168 0.0875127945188733 979 6842497
SGTC_1960 st011366 51.8 µM -1.36250457679077 0.0552013169213575 no 3169 0.0865193503767576 991 3972846
SGTC_229 benomyl 22.8748 µM -1.36746335173473 0.0545440446927719 no 3170 0.0857400584338323 990 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2726 cimetidine 79.27 µM -1.37091523176841 0.0540901722775386 no 3171 0.0852006912656118 1002 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2006 4011487 200 µM -1.37236911320819 0.0538999047572001 no 3172 0.084974280129298 1000 45595294
SGTC_625 k213-0058 121 µM -1.37544281234873 0.053499398407333 no 3173 0.0844971019007116 1008 3655420
SGTC_522 1273-0010 11.6 µM -1.38140509919855 0.0527292317996004 no 3174 0.0835772194553252 977 5705015
SGTC_1153 4055-0057 267 µM -1.38149236789539 0.0527180247092075 no 3175 0.0835638114358814 993 882706
SGTC_611 3453-1652 23.7 µM -1.38302924098171 0.0525209682443322 no 3176 0.083327950056141 1012 1560575
SGTC_414 piperonyl butoxide 100 µM -1.38303742303171 0.0525199207161088 no 3177 0.0833266957110475 1021 5794 A potent inhibitor of cytochrome P450.
SGTC_1123 mangostin 811.285 nM -1.3836193164453 0.0524454648176189 no 3178 0.0832375252274715 960 5281650 An antioxidant.
SGTC_15 0266-0086 27.098 µM -1.38610774096037 0.0521280045606584 no 3179 0.0828570035025561 1025 1712902 YIL048W NEO1
SGTC_642 0335-0876 158 µM -1.39005825306411 0.0516271559427986 no 3180 0.0822555944263949 1011 6812350
SGTC_3248 9135562 49.47 µM -1.39380847787671 0.0511552470128585 no 3181 0.0816877236784431 1000 17650701
SGTC_1171 0368-0077 21.4 µM -1.39492331413591 0.0510156255719309 no 3182 0.0815194828912953 1007 3239779
SGTC_2903 5923464 63.88 µM -1.39829458458031 0.0505952544148678 no 3183 0.081012311712695 1020 2876576
SGTC_1908 st060353 56.5 µM -1.39898862961912 0.0505090558415684 no 3184 0.0809081963887105 1009 4227716
SGTC_2725 haloperidol 53.21 µM -1.40113063762491 0.0502437616210655 no 3185 0.0805875056749783 1001 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1319 1306-0155 43.7 µM -1.40193468553578 0.0501444650024123 no 3186 0.0804673757998715 1005 3122360
SGTC_286 k060-0067 22.9 µM -1.40280104415697 0.0500376484321814 no 3187 0.0803380877812707 1011 5985051
SGTC_675 1309-0189 238 µM -1.40503919042472 0.0497625387432714 no 3188 0.0800048124180725 1007 4246530
SGTC_1057 3448-5381 134 µM -1.41757933914292 0.0482433723680063 no 3189 0.0781568078604658 961 5497911
SGTC_2178 5812956 200 µM -1.42268877571165 0.0476351313375602 no 3190 0.0774131979236518 1004 5403383
SGTC_2096 5468907 200 µM -1.42444012403609 0.0474280651545411 no 3191 0.0771595530970778 1022 759785
SGTC_3007 9078383 71.4286 µM -1.43013151619193 0.0467601338759295 no 3192 0.0763396381393925 1025 6496995
SGTC_89 0302-0250 142.109 µM -1.43520420119092 0.0461711926928945 no 3193 0.0756144583999248 1035 4203518 YLR208W SEC13
SGTC_3016 9080866 49.47 µM -1.43779428421915 0.045872788419866 no 3194 0.0752462158079361 1017 17066299
SGTC_2312 7706453 155.7 µM -1.44376190729819 0.0451911543193153 no 3195 0.0744029803019941 1017 976098
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.44619639534292 0.0449154329876694 no 3196 0.0740610622390133 992 688667
SGTC_2040 5100729 123 µM -1.45025277255457 0.0444590318488966 no 3197 0.0734940218476291 1027 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_3228 9131799 49.47 µM -1.4506462500855 0.0444149594588189 no 3198 0.0734391948052041 1030 17015818
SGTC_72 0744-0168 198.391 µM -1.45154132011485 0.0443148361222726 no 3199 0.0733145925286078 1030 677577
SGTC_2238 6671620 73.2395 µM -1.45383250093691 0.0440593712016505 no 3200 0.0729963751638929 1002 729941
SGTC_2793 7325131 81.82 µM -1.45719975973882 0.0436860807785597 no 3201 0.0725306234576804 1002 4176441
SGTC_828 2074-0507 139 µM -1.46303388498523 0.0430453607481656 no 3202 0.0717290536029858 1006 X828
SGTC_1335 1486-0900 202 µM -1.46489470338723 0.0428426046956512 no 3203 0.0714748240589933 1010 X1335
SGTC_199 4063-0024 41.6 µM -1.46607473767276 0.0427144277673975 no 3204 0.0713139635520553 1041 306215
SGTC_772 k072-0172 35.3 µM -1.46772255428281 0.0425359585685731 no 3205 0.0710898008352864 992 5861980
SGTC_2476 5806916 10.51 µM -1.47017397113502 0.0422715705684028 no 3206 0.0707573211701131 974 2870194
SGTC_2626 ethyl orsellinate 100 µM -1.47391818411406 0.0418703208680548 no 3207 0.0702518105524543 1015 75653 A natural product.
SGTC_634 1611-4317 11.2 µM -1.48050938464718 0.0411714695101189 no 3208 0.0693686790554953 1035 2843522
SGTC_1885 st057546 99.9 µM -1.4939069200953 0.0397801059635477 no 3209 0.067599974739713 992 702008
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.49684647285343 0.0394799986564609 no 3210 0.0672166053818309 1030 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_804 1595-0054 20.9 µM -1.50466995686555 0.038690242347271 no 3211 0.066204475370919 1030 761523 Stimulates phospholipase C.
SGTC_372 0155-0182 15.9 µM -1.50658026403733 0.0384993707196311 no 3212 0.0659591396642706 899 771486
SGTC_2467 5474540 200 µM -1.50864915191903 0.0382935206060712 no 3213 0.0656942331131212 1001 5413519
SGTC_1892 st058411 7.36 µM -1.5128080632777 0.0378824325880477 no 3214 0.0651642100322525 1026 3934738
SGTC_2173 5763948 167 µM -1.51800256620521 0.037374046727687 no 3215 0.0645068758706798 1023 2867177
SGTC_644 1498-1197 63.3 µM -1.5184784696885 0.0373277500678987 no 3216 0.064446911569104 1032 6741615
SGTC_2434 5670830 169.91 µM -1.52863320100827 0.0363509964494582 no 3217 0.0631777002632235 1036 1549830
SGTC_2836 9010338 19.48 µM -1.53240584623777 0.0359934888558184 no 3218 0.0627111578455561 1024 2994051
SGTC_1308 1187-1617 41.4 µM -1.55059822517933 0.0343097336712401 no 3219 0.0604989988748088 1029 2882570
SGTC_1109 tnp00067 928.257 nM -1.55236336823713 0.0341498679206478 no 3220 0.0602876516625317 1031 676295
SGTC_1341 1486-1360 280 µM -1.55822087074227 0.0336237472300869 no 3221 0.0595904495770385 1036 3976547
SGTC_2315 7733312 200 µM -1.5638803173189 0.0331217703677091 no 3222 0.058922838826941 1021 726316
SGTC_3348 9149464 3.537 µM -1.56430359538508 0.0330844762834394 no 3223 0.0588731440923542 1013 1951442
SGTC_3317 9138495 8.753 µM -1.56514440134894 0.0330104973708082 no 3224 0.0587745272732174 1028 17020139
SGTC_900 1112-0045 141 µM -1.56782921371949 0.0327751843176569 no 3225 0.0584604975729564 1010 56211 YIL048W NEO1
SGTC_471 1-acyl-paf 4 µM -1.57238687644379 0.0323788908120491 no 3226 0.0579304279780849 1043 16759367
SGTC_4 0960-0234 25.671 µM -1.57354103560201 0.0322791653042771 no 3227 0.0577967971342562 1012 6821112
SGTC_3350 9150499 3.57 µM -1.57381586221023 0.0322554562233993 no 3228 0.0577650129147578 1041 4910996 YPR165W RHO1
SGTC_2759 disulfiram 3.38 µM -1.57685822466723 0.0319939529102563 no 3229 0.0574140753762627 1007 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2095 5432005 200 µM -1.58036043558285 0.0316950939720449 no 3230 0.057012173383843 1038 783734
SGTC_1254 0550-0035 264 µM -1.58359228775254 0.0314213560654701 no 3231 0.056643265050028 1034 15121435
SGTC_2990 9074105 71.4286 µM -1.59555778592347 0.0304248404401864 no 3232 0.0552937793837813 1039 6502001
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.5971884953254 0.03029108078613 no 3233 0.0551118482096691 1022 688788
SGTC_3282 9108498 15.4605 µM -1.60041663163177 0.0300277286254875 no 3234 0.0547530939722034 1037 16459645
SGTC_3290 9121031 71.43 µM -1.6141410677857 0.0289291920353668 no 3235 0.0532484156322494 1016 17014854
SGTC_654 1124-0271 80.9 µM -1.61788875329034 0.0286350922882206 no 3236 0.0528432872362652 1044 5403748
SGTC_2596 sinensetin 100 µM -1.61833404643771 0.0286003137556978 no 3237 0.0527953135790433 1022 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2796 7949634 45.45 µM -1.62644953838185 0.0279726033731414 no 3238 0.0519270298991548 1016 2971588
SGTC_2236 dapsone 200 µM -1.65043967284767 0.0261837865017304 no 3239 0.0494265212300268 1042 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1190 1486-1332 13 µM -1.65044345119605 0.0261835124875637 no 3240 0.0494261351189664 1024 4150046
SGTC_2702 st077768 96.8 µM -1.65321688301255 0.025983022907503 no 3241 0.0491433658317655 1029 6484119
SGTC_1186 1319-0216 26 µM -1.65703284276909 0.0257092700858967 no 3242 0.0487564176244609 1034 4565136
SGTC_1328 1441-0025 69.2 µM -1.65928620458736 0.0255487530367934 no 3243 0.0485290669025747 1037 4562601
SGTC_797 k781-0471 270 µM -1.65933701166151 0.0255451435174228 no 3244 0.0485239505614457 1010 23738129
SGTC_460 trequinsin 123 µM -1.66020922041686 0.0254832451913428 no 3245 0.0484361851989982 1073 5537 A vasodilator.
SGTC_2884 9058502 51.95 µM -1.66134317434176 0.0254029593602467 no 3246 0.0483222717859699 1036 6471554
SGTC_1105 epirubicin 18.1 µM -1.6629877776455 0.0252868952508285 no 3247 0.0481574410487995 1035 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3291 9121177 71.43 µM -1.66688231387374 0.0250138181104541 no 3248 0.0477689041604183 1033 17015612
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.66702083684684 0.025004150865386 no 3249 0.0477551308337236 1032 6708760
SGTC_1594 piperine 70.1 µM -1.66781889068673 0.0249485172473408 no 3250 0.0476758423355085 1044 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1998 st075797 76.8 µM -1.6717044963078 0.0246791261843977 no 3251 0.0472913035437132 1033 24208315
SGTC_1256 0570-0116 285 µM -1.67274712197597 0.0246072571016848 no 3252 0.0471885442333373 1046 410638
SGTC_2784 7567673 72.73 µM -1.68166540281868 0.0239996588346395 no 3253 0.0463168702095057 1022 3471247
SGTC_179 1273-0063 6.77 µM -1.68174058433596 0.0239945908300563 no 3254 0.0463095772866379 1050 3108139
SGTC_1668 st014914 51.6 µM -1.68562688044186 0.0237338367105844 no 3255 0.0459338442090584 1064 2839556
SGTC_638 3970-0837 4.09 µM -1.69195321953984 0.0233144635670113 no 3256 0.0453274467494488 1038 4118451 YLR208W SEC13
SGTC_3008 9078912 71.4286 µM -1.69656851081926 0.0230124654587903 no 3257 0.0448891336701047 1047 16648731
SGTC_88 0180-0332 8.668 µM -1.69824251057759 0.0229037458536451 no 3258 0.0447310000995331 1040 3101745
SGTC_1076 itraconazole 331 nM -1.71099648116648 0.0220895502603566 no 3259 0.0435408812067872 1049 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1281 0884-0031 11.8 µM -1.72044703622703 0.0215021176609619 no 3260 0.0426756066366562 1045 1548255
SGTC_1373 2887-0003 58.5 µM -1.72835222156139 0.0210209364545143 no 3261 0.0419625479260556 1039 776948
SGTC_2112 5488546 200 µM -1.74822807845955 0.0198512126628287 no 3262 0.0402122706932324 1057 600757
SGTC_2241 6772625 37.8075 µM -1.75882964437578 0.019250209005323 no 3263 0.0393032240126619 1027 2285411
SGTC_1978 st071761 42 µM -1.75996519572575 0.0191867611553902 no 3264 0.0392068539575827 1045 5147680
SGTC_1150 3909-7983 10.9 µM -1.76132139695579 0.0191112177210587 no 3265 0.0390920102572378 1052 23965914
SGTC_633 0437-0093 97.7 µM -1.76834508386322 0.0187240168103436 no 3266 0.0385016156200797 1046 2831118
SGTC_2507 purpurin 79.67 µM -1.77288430101728 0.0184773474838966 no 3267 0.0381239402760302 1051 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_383 2324-0395 7.37 µM -1.7735498028162 0.0184414165419172 no 3268 0.0380688235355105 974 3146421
SGTC_2749 bexarotene 57.39 µM -1.77707257597171 0.0182522090473074 no 3269 0.0377781497993765 1037 82146 An retinoic acid receptor inhibitor.
SGTC_148 3253-0744 288.01 µM -1.77957423183084 0.0181188521662609 no 3270 0.0375728332150914 1028 6893655
SGTC_1697 st025554 27.742 µM -1.79129302042048 0.0175051575251565 no 3271 0.0366231427894333 1051 1269519
SGTC_672 1441-0018 53.7 µM -1.79672983725056 0.0172265210605092 no 3272 0.0361892598717503 1036 251141
SGTC_1337 1486-1011 40.3 µM -1.80635165511839 0.0167426868186674 no 3273 0.0354317140001221 1050 X1337
SGTC_370 0180-0345 38.7 µM -1.8069468094283 0.0167131450245501 no 3274 0.0353852865216553 1022 3989527
SGTC_2911 7942208 15.64 µM -1.83414575168975 0.0154098372558936 no 3275 0.0333161807756362 1027 1243384
SGTC_2008 4012253 172 µM -1.8349750991594 0.0153715078955072 no 3276 0.0332546895330458 1020 603940
SGTC_2339 9000433 200 µM -1.83584054037266 0.0153315977287798 no 3277 0.033190621850886 1038 2988954
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.84551048462701 0.0148916825179214 no 3278 0.0324816573730045 1032 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_770 0389-1121 67.2 µM -1.86254754420472 0.0141429947427572 no 3279 0.0312629751885892 1068 6753108
SGTC_1669 st015249 58.4 µM -1.86415643658035 0.0140739983131299 no 3280 0.0311498695010973 1083 722793
SGTC_2423 st077119 87.2 µM -1.87013089841705 0.0138203196245893 no 3281 0.0307328213311973 1046 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1981 st071826 47 µM -1.87198809960947 0.0137422696913689 no 3282 0.030604124962367 1047 11838600
SGTC_2391 6285546 200 µM -1.87214671715055 0.013735621358187 no 3283 0.030593154140607 1055 846083
SGTC_864 0469-0573 172 µM -1.88254728214037 0.0133057026059055 no 3284 0.0298808732265873 1071 689425
SGTC_665 3914-0008 307 µM -1.88439379606649 0.0132306024194422 no 3285 0.029755864197294 1066 1069549
SGTC_1911 st060208 74.3 µM -1.89457483818229 0.01282306847585 no 3286 0.0290743754574439 1054 688783
SGTC_2380 9035439 200 µM -1.89871968726242 0.0126602920581481 no 3287 0.0288006708189708 1052 6462575
SGTC_1982 st072467 71.9 µM -1.90192479776377 0.0125356499870568 no 3288 0.0285904933806487 1059 3163533
SGTC_527 4476-4215 268 µM -1.90629090603448 0.0123675685826624 no 3289 0.0283062367293369 1051 4418754
SGTC_2864 9034755 47.6 µM -1.90652794240038 0.012358499563755 no 3290 0.0282908719689834 1049 4930451
SGTC_230 MPP+ 141.667 µM -1.90847971257433 0.0122840435270621 no 3291 0.0281646214118668 1060 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1267 0828-0272 9.49 µM -1.92378256486845 0.0117136230390544 no 3292 0.0271909218696886 1063 745334
SGTC_42 0133-0086 60.653 µM -1.92537365461981 0.0116556553428332 no 3293 0.027091314541266 1052 162923 Model of phenazepam hydroxylation.
SGTC_2086 5274770 176.623 µM -1.93262105370377 0.0113947528262879 no 3294 0.0266414484506379 1054 689278
SGTC_50 0929-0078 56.389 µM -1.94207992599835 0.01106188148807 no 3295 0.026063712623431 1030 1377751
SGTC_454 lyso-paf C-16 6.67 µM -1.94251173914312 0.0110468893508476 no 3296 0.0260375901003071 1063 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_97 0535-0701 19.132 µM -1.96666945322793 0.0102358259135205 no 3297 0.024610665356446 1026 2832013 YGL099W LSG1
SGTC_417 st075190 100 µM -1.96937176116045 0.0101484124505117 no 3298 0.0244552080305352 1065 222757
SGTC_1613 st002381 52.1 µM -1.9770690771596 0.00990298200395619 no 3299 0.0240169112884114 1065 551167
SGTC_371 0195-0006 7.36 µM -1.98247494759887 0.00973372766863171 no 3300 0.0237130542958121 1027 3928593
SGTC_2862 9027634 71.43 µM -1.98411605467887 0.0096828482461874 no 3301 0.0236214518826943 1044 5012562
SGTC_1044 1222-0021 1.78 µM -1.98416765447651 0.00968125226737769 no 3302 0.0236185765460286 1018 4306703
SGTC_1623 st003709 20.3 µM -1.98600981239747 0.00962442481556268 no 3303 0.0235161171904152 1063 16192618
SGTC_258 haloperidol 50.781 µM -1.98650655829859 0.00960915103994405 no 3304 0.0234885526731956 1075 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2200 6600604 21.907 µM -1.98711356129654 0.00959051588089392 no 3305 0.023454906876521 1076 2904777
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.99115542427362 0.00946723314590615 no 3306 0.0232319013705109 1072 279621
SGTC_700 3453-2283 142 µM -1.99119212854246 0.00946611999120612 no 3307 0.0232298844577045 1058 565664
SGTC_1175 0741-0056 27.6 µM -1.99913286850048 0.00922797062239755 no 3308 0.022796989830264 1073 765927
SGTC_1303 1160-0052 261 µM -2.00249939210736 0.00912859915915709 no 3309 0.0226155242107437 1065 3562476
SGTC_1462 k081-0014 26.5 µM -2.01398362840034 0.00879662757387954 no 3310 0.0220056261868644 987 3270634
SGTC_2189 6047310 154.431 µM -2.06154097496116 0.00753194759398251 no 3311 0.0196257292770082 1064 711535
SGTC_2987 9018338 71.43 µM -2.07011061306882 0.0073219278878793 no 3312 0.0192209936250421 1065 5055682
SGTC_1463 k081-0032 34.1 µM -2.07195398979934 0.00727743206193124 no 3313 0.0191348661140556 1013 977755
SGTC_380 3970-0968 6 µM -2.07241775010771 0.0072662753192957 no 3314 0.0191132497159449 1074 2891601
SGTC_196 k015-0023 18.111 µM -2.08477310040789 0.00697454184148202 no 3315 0.0185449507735606 1066 5211998
SGTC_2400 5203494 178.7 µM -2.08923106846338 0.00687184755302249 no 3316 0.0183434639991696 1053 6777674
SGTC_867 0518-0118 155 µM -2.10333887735654 0.00655560432549369 no 3317 0.0177180786506539 1062 6848158
SGTC_1037 k284-1091 78.7 µM -2.12119666693541 0.00617379935970982 no 3318 0.0169526278248676 1068 3334711
SGTC_3305 9127027 53.8275 µM -2.13372135061459 0.00591790140821937 no 3319 0.0164327986400022 1068 41905295
SGTC_2199 6590217 200 µM -2.19801737183283 0.00474672225723546 no 3320 0.0139739340059714 1055 703109
SGTC_1638 st008370 60.6 µM -2.21420802293456 0.00448650323966459 no 3321 0.0134072361117473 1056 24207134
SGTC_1129 3453-1384 223 µM -2.26983498173225 0.00368678795399695 no 3322 0.01160879861209 1077 1084452
SGTC_2727 riluzole 51.77 µM -2.30980156834888 0.00319378579690823 no 3323 0.0104495712200919 1084 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2558 carylophyllene oxide 100 µM -2.33326622035924 0.00293278697568462 no 3324 0.00981708859540665 1083 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2996 9066192 71.4286 µM -2.37383068371165 0.00252657783596593 no 3325 0.00880231059370019 1067 6472854
SGTC_3355 9151058 44.0485 µM -2.46163284399781 0.00181620371553082 no 3326 0.00691530841442873 1089 17015728
SGTC_3356 9151811 4.48 µM -2.46443371267562 0.00179687758075187 no 3327 0.0068614972185196 1087 1859254 YPR165W RHO1
SGTC_691 1548-0686 185 µM -2.48786105003523 0.00164240815747288 no 3328 0.00642569663540544 1078 46495133
SGTC_2923 7992654 58.14 µM -2.50655334535401 0.00152794542349227 no 3329 0.00609573298389538 1075 2985126
SGTC_2760 etidronate 98.04 µM -2.51877674577427 0.00145708031152761 no 3330 0.00588816494369173 1073 3305 A chelator and antioxidant.
SGTC_264 promethazine 12.5 mM -2.55531188540166 0.00126277576772792 no 3331 0.00530463447250499 1082 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2007 4011539 71.82 µM -2.55906289293454 0.00124423146077864 no 3332 0.00524773757576427 1071 45595301
SGTC_483 fpl-64176 144 µM -2.58134256087277 0.00113912557063369 no 3333 0.00492084350757566 1089 3423
SGTC_226 1,3-diallylurea 8.28947 mM -2.60287778261415 0.00104532402304336 no 3334 0.00462224511653031 1086 74537 YKL182W FAS1
SGTC_2092 5303694 80.6725 µM -2.6075408567505 0.00102596980587902 no 3335 0.00455975933059589 1087 1963699
SGTC_2835 9006588 71.43 µM -2.62659967743139 0.000950235369296777 yes 3336 0.00431213646179069 1054 2345538
SGTC_2984 9022109 38.96 µM -2.66879031202405 0.000800499919996179 yes 3337 0.00380624794959994 1092 6459207
SGTC_1048 3161-0300 24.5 µM -2.68453731276742 0.000750417471203748 yes 3338 0.00363151378284501 1084 2165101
SGTC_1261 0712-0010 12.7 µM -2.70313165023572 0.000695002635091876 yes 3339 0.00343447671575644 1080 2840123
SGTC_1062 mesoridazine 14.2 µM -2.78918784068004 0.000484380366595116 yes 3340 0.00264202039459212 1086 4078 A neuroleptic.
SGTC_2407 paclitaxel 400 µM -2.81205463112434 0.000439338554306999 yes 3341 0.0024613070865216 1082 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2979 9012552 45.46 µM -2.91157306173297 0.000284960865940121 yes 3342 0.00179806897237183 1093 17100905
SGTC_3005 9076496 71.4286 µM -2.94290135236083 0.00024797328922135 yes 3343 0.00162576004804393 1089 21368410
SGTC_2406 ethylparaben 405.7 µM -2.98073229029691 0.000209280400232031 yes 3344 0.00143780027948344 1087 8434 A possible steroid mimic.
SGTC_1099 5-nonyloxytryptamine 2.85 µM -3.02460025117754 0.000171493786821763 yes 3345 0.00124480973155506 1091 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3349 9149703 23.001 µM -3.02684536278762 0.000169743118630608 yes 3346 0.00123560171526007 1090 4910494
SGTC_1050 3232-1156 69.3 µM -3.03873233902518 0.000160749329342018 yes 3347 0.00118787915395092 1087 700529
SGTC_741 4582-0002 126 µM -3.04737883328154 0.00015448968943465 yes 3348 0.00115423286463878 1090 2912688
SGTC_1612 st002233 45.4 µM -3.19214766879783 7.82674468661022e-05 yes 3349 0.000706095575678748 1093 1035021
SGTC_2587 piperic acid 92.2 µM -3.2266580241077 6.62776457327774e-05 yes 3350 0.000626225256930618 1088 5370536
SGTC_1621 st003705 32.4 µM -3.54593167288091 1.31825421277447e-05 yes 3351 0.000195613816795656 1091 24207032
SGTC_2691 st077356 60.2 µM -3.58885513193313 1.04981540484798e-05 yes 3352 0.000166066664767427 1094 2839272
SGTC_1036 k216-0215 33.5 µM -3.60626109555818 9.56538231514124e-06 yes 3353 0.000155320292979485 1058 622330
SGTC_869 0564-0080 44.1 µM -3.82528079291286 2.86317078460226e-06 yes 3354 6.53115592159099e-05 1091 6843321
SGTC_620 0109-0052 432 µM -4.10467461661385 5.58648561481484e-07 yes 3355 2.02442175872235e-05 1095 493037