SGTCid condition conc unit SAS2|YMR127C.score SAS2|YMR127C.strain.pval SAS2|YMR127C.strain.significant SAS2|YMR127C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1121 fusaric acid 630.51 nM 17.8187687408438 1.01371875455899e-80 yes 1 2.52683093863951e-71 3 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_862 0452-0056 10.2 µM 11.3662144907657 4.36998317691569e-34 yes 2 3.08008407650506e-30 2 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_158 k038-0087 26.446 µM 9.66953166497063 3.2532887311407e-25 yes 3 2.03116405245869e-22 32 X158 SGTC_1246 0422-0085 105 µM 9.0885674640146 1.68516492958175e-22 yes 4 5.01762514732856e-20 1 264295 SGTC_1317 1273-0028 910 nM 8.84202470726675 2.13161590081209e-21 yes 5 4.69997144706791e-19 14 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_996 3970-0799 1.8 µM 7.56885802931571 3.53427323753027e-16 yes 6 1.88259679425742e-14 23 6615648 YGL040C HEM2 SGTC_1829 berberine 14.4 µM 7.37700906473005 1.84684021007056e-15 yes 7 8.09424949937098e-14 1 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1827 berberine 7.24 µM 6.36464799966327 5.7560056747472e-12 yes 8 9.78690520022099e-11 2 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2616 abietic acid 100 µM 6.29862075024936 9.34847645304702e-12 yes 9 1.50152869417115e-10 9 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_36 0335-0881 14.2 µM 6.29724456883802 9.44296289663101e-12 yes 10 1.5149152395476e-10 58 23828853 SGTC_794 k038-0031 316 µM 6.28827527594 1.0082094766474e-11 yes 11 1.60506162908768e-10 50 6624242 SGTC_64 000l-0018 272.079 µM 6.07050335956618 4.81058507609432e-11 yes 12 6.375497450382e-10 79 6811119 SGTC_67 0335-0847 266 µM 6.05144375082136 5.50178763699318e-11 yes 13 7.17767051698402e-10 68 4552207 YOR254C SEC63 SGTC_86 0417-1630 471.922 µM 5.8918141451424 1.66705777519832e-10 yes 14 1.909893276987e-09 90 3634867 SGTC_2605 digitonin 300 nM 5.53303435032887 1.81643760169827e-09 yes 15 1.57368901266161e-08 5 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2608 thymoquinone 42.66 µM 5.30027757989641 7.92553020700381e-09 yes 16 5.78133748442316e-08 7 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2610 ononetin 44.17 µM 5.14051431085738 2.10444380398284e-08 yes 17 1.36993726890827e-07 13 259632 SGTC_363 0455-0021 3.06 µM 5.02529305000668 4.18226175790165e-08 yes 18 2.51332182154288e-07 41 4597466 SGTC_142 0335-0849 62.6745 µM 5.02458597288623 4.19973605851345e-08 yes 19 2.52259877812318e-07 83 3889043 YPR107C YTH1 SGTC_340 k038-0059 454 µM 4.46672495522039 9.49376061891281e-07 yes 20 3.97130690026567e-06 38 23733424 SGTC_327 1273-0057 3.96 µM 4.33597273024671 1.87668536592202e-06 yes 21 7.25584676874698e-06 24 3108138 SGTC_367 0335-0881 7.1 µM 4.26623469826541 2.6786820334866e-06 yes 22 9.93998229426904e-06 60 23828853 SGTC_2511 berberine 10.47 µM 4.2588160205905 2.78114821254532e-06 yes 23 1.02756262716394e-05 16 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1379 2144-0755 36.5 µM 4.18726914123935 3.98211049713488e-06 yes 24 1.41165478672151e-05 16 5392327 SGTC_470 aa-861 153 µM 4.18024668181734 4.12366514539577e-06 yes 25 1.45596517792232e-05 46 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_279 1273-0055 2.93 µM 4.1111179447835 5.79923402989717e-06 yes 26 1.96873994055761e-05 36 2847562 SGTC_216 k038-0035 28.382 µM 3.97109311217766 1.13869026048286e-05 yes 27 3.57718042148157e-05 47 4444231 YPR107C YTH1 SGTC_200 k038-0079 37.545 µM 3.85567492002167 1.95427772974839e-05 yes 28 5.7705385732544e-05 58 3436683 SGTC_2239 6685329 187.64 µM 3.8206758763286 2.29551062925006e-05 yes 29 6.65432300599038e-05 34 805680 SGTC_154 3389-1638 511.116 µM 3.78795126946054 2.66507031347926e-05 yes 30 7.59473155907721e-05 29 5238686 SGTC_846 0335-0850 148 µM 3.77607942545892 2.81256743189858e-05 yes 31 7.96581040327409e-05 36 6819598 SGTC_258 haloperidol 50.781 µM 3.72573571794783 3.52835495923909e-05 yes 32 9.73731827444256e-05 40 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3337 9144342 33.5465 µM 3.64276053010226 5.09646121457075e-05 yes 33 0.000134864875228528 33 17682949 SGTC_137 0438-0332 85.389 µM 3.60600417558455 5.98382194310402e-05 yes 34 0.000155474067155373 146 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_165 k038-0023 64.381 µM 3.57069859684275 6.97173643940494e-05 yes 35 0.000178015196226137 100 46368543 SGTC_2602 kawain 100 µM 3.54892352027956 7.65560516869234e-05 yes 36 0.000193404704308208 38 5369129 SGTC_1786 berberine 21.6 µM 3.54614103511673 7.74740843099721e-05 yes 37 0.000195458464441065 46 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_310 1273-0058 1.06 µM 3.49915321272985 9.46307059655242e-05 yes 38 0.00023336915169966 286 2734232 SGTC_1423 4048-0112 5.59 µM 3.40192155311733 0.000142077926826073 yes 39 0.000334569210393566 44 X1423 SGTC_618 k072-0232 33.2 µM 3.3094012747225 0.000207192705563131 yes 40 0.000467478662139577 23 5872756 YGL099W LSG1 SGTC_1200 1643-0193 18.4 µM 3.28736783468713 0.000226363665780984 yes 41 0.000505643229828773 34 5403974 SGTC_3168 9103419 49.47 µM 3.19920772877228 0.000320866174341997 yes 42 0.000689029178592391 12 16649256 SGTC_2016 5121758 140 µM 3.16623467551192 0.000364809662474912 yes 43 0.000772130766254888 92 2795203 SGTC_1910 st062352 60.4 µM 3.15361677222543 0.000383057612525857 yes 44 0.000806303489545444 69 2245730 SGTC_2840 9008771 71.43 µM 3.04701997436934 0.000574648796845944 yes 45 0.00115561175448607 34 2992978 SGTC_2770 toltrazuril 17.5 µM 3.00869814375719 0.000662889636453993 yes 46 0.00131184826253204 73 68591 Kills coccidiodes. SGTC_2899 9053889 58.44 µM 2.96447670127918 0.000780169206444903 yes 47 0.00151599100710918 32 6470052 SGTC_1120 ficusin 1.78878 µM 2.95671276730794 0.000802632809275358 yes 48 0.00155468811319265 63 6199 A DNA cross-linker. SGTC_3253 9135987 49.47 µM 2.93599160524214 0.000865532686960633 yes 49 0.00166241660005744 45 4182430 SGTC_1513 0337-0559 19 µM 2.93057803577035 0.000882696563418987 yes 50 0.00169166002555021 70 775073 SGTC_266 formosanin C 406 nM 2.92540147627253 0.000899401119172337 yes 51 0.00172006044293464 133 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_655 k060-0012 42 µM 2.91820360476518 0.000923111488551864 yes 52 0.0017602719552757 58 5994525 SGTC_2208 7283366 200 µM 2.86625260853523 0.00111201684039786 no 53 0.0020768133106956 45 898663 SGTC_886 0866-0150 153 µM 2.8648801563236 0.00111745657377283 no 54 0.002085835446045 75 271463 SGTC_63 0099-0242 26.702 µM 2.83093058308134 0.00126002494709812 no 55 0.0023206396435643 170 3898502 YLR359W ADE13 SGTC_3331 9141060 1.957 µM 2.82487537940297 0.0012871368348747 no 56 0.00236495041584657 83 4906567 YPR165W RHO1 SGTC_3315 9136395 68.55 µM 2.81009320116782 0.00135557870320717 no 57 0.00247635776915792 58 16876844 SGTC_2532 xanthone 78.9 µM 2.79796775476944 0.00141418482016061 no 58 0.00257126231233881 83 7020 An insecticide. SGTC_1186 1319-0216 26 µM 2.79122919495393 0.00144774575241875 no 59 0.00262541380491979 78 4565136 SGTC_998 3996-0085 177 µM 2.78063781573595 0.00150196700583633 no 60 0.00271261133357998 72 715391 SGTC_3178 9107506 49.47 µM 2.77620355810459 0.00152521282946095 no 61 0.00274988815438506 67 8897194 SGTC_431 k089-0097 107 µM 2.72428749411094 0.00182286303779079 no 62 0.00322201925637098 136 5499420 SGTC_1738 st035555 74 µM 2.72376120329752 0.00182613382168912 no 63 0.00322715775608226 104 5331140 SGTC_1909 st060837 51.5 µM 2.70670656677279 0.00193505663233319 no 64 0.00339771458546385 131 678937 SGTC_1097 itavastatin 7.23 µM 2.69909115855069 0.00198557351763251 no 65 0.00347645640902789 82 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1741 st038134 10.228 µM 2.68257017703268 0.00209930587225889 no 66 0.00365294108558399 113 1272587 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 2.66386226655068 0.00223520443891418 no 67 0.00386245922918002 129 551469 SGTC_333 3486-0131 40.1 µM 2.65634352410764 0.00229203228709282 no 68 0.00394965503633876 63 6744690 SGTC_700 3453-2283 142 µM 2.64923180890793 0.00234698464950087 no 69 0.00403374874185828 116 565664 SGTC_688 0527-0193 473 µM 2.64495018281672 0.0023806413339178 no 70 0.00408514723364552 62 4007154 SGTC_1051 3253-3903 78 µM 2.58424017398919 0.00290721028870996 no 71 0.0048796903589255 118 5509239 SGTC_2793 7325131 81.82 µM 2.57120438101281 0.00303313748001019 no 72 0.00506727487982943 96 4176441 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 2.55240364540339 0.00322341345344019 no 73 0.00534912481021668 142 23665772 A membrane-active detergent. SGTC_2382 9035899 200 µM 2.53847809700747 0.00337120077114437 no 74 0.00556678858841311 89 6462679 SGTC_465 cgp-37157 41 µM 2.53445641830063 0.00341500040388538 no 75 0.00563109676184827 54 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_182 3448-4371 550.524 µM 2.5286800020646 0.00347880546986224 no 76 0.00572461803457654 106 3491403 SGTC_1725 st036284 20.55 µM 2.52372537768403 0.00353438410299773 no 77 0.0058059300335097 130 707914 SGTC_1998 st075797 76.8 µM 2.49786038248979 0.00383767504160961 no 78 0.00624726963968157 117 24208315 SGTC_763 3453-1109 128 µM 2.48633684804648 0.00398015730140664 no 79 0.00645328675281193 117 1560353 SGTC_953 1188-0045 9.7 µM 2.48548719100229 0.00399084804097495 no 80 0.00646871214706518 135 6144426 SGTC_571 k831-0106 44.2 µM 2.48528941640717 0.00399334020986198 no 81 0.00647230739134536 105 4783639 SGTC_907 3448-6986 75.5 µM 2.47916854878846 0.00407116185215468 no 82 0.00658445302153453 134 590582 SGTC_3013 9080133 71.4286 µM 2.46966444072399 0.00419469068673155 no 83 0.00676199226316897 120 17050193 SGTC_466 geldanamycin 89.2 µM 2.45354142798179 0.00441193243587846 no 84 0.0070728622128191 68 5288382 HSP90 inhibitor. SGTC_1644 st010134 20.9 µM 2.41654408068058 0.00494886148934826 no 85 0.0078343144583808 87 3818134 SGTC_41 0478-0632 82.643 µM 2.40500228540617 0.00512788828138542 no 86 0.0080861823227722 167 3750424 SGTC_1431 4049-0260 9.09 µM 2.38396465105912 0.00546908781518734 no 87 0.00856362372708148 110 3854841 SGTC_3251 9135047 49.47 µM 2.36441315621553 0.00580411917498659 no 88 0.00902933034777023 76 17682963 SGTC_1630 st005209 31.3 µM 2.33890897554323 0.00626846247907826 no 89 0.00967007244012363 176 3367314 SGTC_2378 9074213 121.43 µM 2.3316190070519 0.00640709633786197 no 90 0.00986037150805736 152 657714 SGTC_2045 5106652 78.05 µM 2.32866899494499 0.00646396360444647 no 91 0.00993830393217014 111 673349 SGTC_802 4112-3352 742 µM 2.32833726380588 0.00647038621942095 no 92 0.0099471010389656 153 704594 SGTC_2550 chrysin dimethyl ether 71.87 µM 2.32538489509601 0.00652779590786322 no 93 0.0100256942174634 77 88881 An O-methylated flavonoid and antioxidant. SGTC_2284 7945075 39.21 µM 2.31623367144417 0.0067086167865075 no 94 0.0102727568280627 170 1245402 SGTC_2156 5649887 115 µM 2.31086643329442 0.00681671625202183 no 95 0.0104201168192745 149 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 2.2887584791992 0.00727837596208803 no 96 0.0110466945769679 146 2333 A French combination drug. SGTC_445 e6 berbamine 66 µM 2.28813371384316 0.00729181353874611 no 97 0.011064867721265 313 6610268 A calcium/calmodulin antagonist. SGTC_865 0488-0499 301 µM 2.26726217474685 0.0077534756700442 no 98 0.0116871073411109 128 9634651 SGTC_357 1325-0123 420 µM 2.26177872261926 0.00787895344560297 no 99 0.0118555390432765 119 1098503 SGTC_1030 k029-0042 36.7 µM 2.25769579243452 0.00797353980058896 no 100 0.0119823158705036 189 6080581 SGTC_2350 9023895 38.85 µM 2.24096049431979 0.00837174667643532 no 101 0.0125143170556625 165 2997209 SGTC_3346 9158254 43.5805 µM 2.23402911241942 0.00854172230955169 no 102 0.0127405787955085 161 17639500 SGTC_1605 st000082 49.1 µM 2.19965480100255 0.00943016825425028 no 103 0.0139156979582776 153 1114022 SGTC_884 0851-0618 334 µM 2.19693203356994 0.00950387804594462 no 104 0.0140126503214827 177 9642473 SGTC_1311 1190-0148 100 µM 2.1963650291848 0.00951929100710654 no 105 0.0140329133135312 204 1961333 SGTC_1410 3909-8106 77.9 µM 2.19367010611603 0.00959284663961136 no 106 0.0141295672078711 125 1039210 SGTC_1020 4335-0961 93.3 µM 2.18372508739637 0.00986860394139905 no 107 0.0144912275808932 162 669075 SGTC_221 trifluoperazine 10.304 µM 2.17953409438712 0.00998687024295139 no 108 0.0146460073654869 404 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2341 7987486 176.74 µM 2.15703366961764 0.0106431945162893 no 109 0.0155015205579948 205 1258686 SGTC_314 1671-0008 2.74 µM 2.15622911406942 0.0106673428555756 no 110 0.0155328896192257 246 3913060 SGTC_2340 7987427 183.45 µM 2.14737843274444 0.0109361573387755 no 111 0.0158815831136844 185 2239331 SGTC_2716 st080858 38.6235 µM 2.14532709542253 0.0109992958107167 no 112 0.0159633517880948 157 5296050 SGTC_2557 derrustone 83.84 µM 2.1390591995987 0.0111941852778183 no 113 0.0162154371036809 234 629853 An antioxidant. SGTC_2795 7780010 54.55 µM 2.13881184071654 0.0112019376706055 no 114 0.016225455060279 187 953673 SGTC_566 0958-0068 16.5 µM 2.13054859283117 0.011463609631447 no 115 0.0165631742558768 153 6815365 SGTC_696 1560-0013 611 µM 2.12604578771892 0.0116084224973098 no 116 0.0167497236073816 182 1650269 SGTC_215 1287-0124 461.5 µM 2.12285071942775 0.0117121387335013 no 117 0.0168831815659418 96 5560863 SGTC_1341 1486-1360 280 µM 2.11741629221148 0.0118903955524668 no 118 0.0171122663411005 189 3976547 SGTC_1832 st054113 55 µM 2.10881827338965 0.0121772301888028 no 119 0.0174801353428581 135 1251267 SGTC_1755 st041960 45.185 µM 2.10198804055985 0.0124093463106412 no 120 0.0177771617221396 184 2257073 SGTC_664 1222-0054 14.9 µM 2.09760722994393 0.0125602309780919 no 121 0.017969927949352 213 6813991 SGTC_85 0868-0259 160.055 µM 2.09530918819718 0.0126400137447785 no 122 0.0180717581093572 142 83173 SGTC_259 usnic acid 108.925 µM 2.09005634219913 0.0128240293841437 no 123 0.0183063694036033 201 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_823 0417-1665 178 µM 2.08825635043016 0.0128876168610164 no 124 0.0183873583088002 207 3429856 SGTC_1468 k284-1086 134 µM 2.08618148841606 0.0129612527017396 no 125 0.0184810932093709 264 15996457 SGTC_2913 7966556 36.57 µM 2.08336120971761 0.0130619261394127 no 126 0.0186091556260208 156 2976516 SGTC_1629 st005085 44.9 µM 2.08030207751284 0.0131718892663838 no 127 0.0187489171866363 230 24207091 SGTC_749 1000-0129 128 µM 2.07307323751278 0.0134349193185385 no 128 0.0190827321126741 210 708470 SGTC_1361 1608-0041 5.61 µM 2.05857306168081 0.0139762228673564 no 129 0.0197675777765803 190 X1361 SGTC_1867 st057372 64 µM 2.04319530574633 0.0145707275639327 no 130 0.0205165541309762 191 688837 SGTC_1875 nocodazole 6 µM 2.0318029144303 0.015025074844444 no 131 0.0210868060235519 214 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2330 7979373 200 µM 2.02259353641307 0.0154012098536153 no 132 0.0215575355740556 255 1863007 SGTC_2123 5259487 200 µM 2.01726187801851 0.0156226421195101 no 133 0.0218340958396634 216 2173474 SGTC_1546 5-methoxyflavanone 78.7 µM 2.01409533258294 0.0157554425000936 no 134 0.0219997627372361 194 147795 SGTC_967 1306-0166 352 µM 2.00641479723724 0.0160815817705257 no 135 0.0224060054350438 235 4437607 SGTC_1251 0490-5699 265 µM 1.99956125331359 0.0163774723353993 no 136 0.0227738307013018 258 3883818 SGTC_1987 st072290 61.9 µM 1.99313021583194 0.0166593492713927 no 137 0.0231235950435378 207 54697379 SGTC_987 1497-1013 404 µM 1.97391845145141 0.0175262633222828 no 138 0.0241955081704528 174 1676435 SGTC_2371 9071574 200 µM 1.97183384822276 0.017622605059454 no 139 0.0243142884810283 176 45596039 SGTC_1822 st052468 42 µM 1.96216312156898 0.018075479472411 no 140 0.024871747982683 189 2873678 SGTC_418 lividomycin a 100 µM 1.95224291980381 0.0185503077343078 no 141 0.0254546853685967 204 72394 An antibiotic. SGTC_1197 1601-0112 267 µM 1.94479249006732 0.0189138673048209 no 142 0.0258999791754654 261 7350313 SGTC_910 3454-3003 490 µM 1.94456100205737 0.0189252596616626 no 143 0.0259139183854195 270 820824 SGTC_2764 methyldopa 94.69 µM 1.94229805262262 0.0190369352903357 no 144 0.0260505143215408 251 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2829 7992743 58.44 µM 1.94114170639087 0.0190942165164286 no 145 0.0261205457478602 276 16462845 SGTC_2172 5754775 163.918 µM 1.92904027894594 0.0197025200043242 no 146 0.0268629310131975 253 2263357 SGTC_2894 9048625 32.47 µM 1.923861558841 0.0199678226244594 no 147 0.0271859693951557 220 4092861 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.91462757666728 0.020448395603008 no 148 0.0277700078439943 138 77254 SGTC_737 1950-0117 57.9 µM 1.91160155631946 0.0206079988237772 no 149 0.0279636597847847 241 5393513 SGTC_104 0074-0074 590.992 µM 1.90876817369023 0.0207583969931553 no 150 0.0281460021040975 132 3943124 SGTC_399 oxolinic acid 75 µM 1.89377646794524 0.0215697234377147 no 151 0.0291273432096403 203 4628 A DNA gyrase inhibitor. SGTC_1135 dihydrocapsaicin 536.708 nM 1.88340939604846 0.0221463124112767 no 152 0.0298224539894414 288 107982 A Capsaicinoid. SGTC_2365 9042475 200 µM 1.86939362578186 0.0229464675051187 no 153 0.0307840353763772 284 6464479 SGTC_147 4466-0538 29.23 µM 1.8682414826863 0.0230133126485136 no 154 0.0308642095250845 288 6742687 YHR072W ERG7 SGTC_1979 st071809 45.3 µM 1.86278730028915 0.0233319838112636 no 155 0.0312460987479993 240 4976333 SGTC_419 nsc-638432 893 µM 1.86206423875812 0.0233745075740589 no 156 0.0312970179942403 260 368090 SGTC_1413 3910-0535 34.4 µM 1.85647075081745 0.0237056733122275 no 157 0.0316932441677287 251 2876951 SGTC_379 3970-0972 5.9 µM 1.85035482393632 0.0240722766432654 no 158 0.0321312128444285 284 2898042 YBL034C STU1 SGTC_1296 1068-0102 11.9 µM 1.8494180809478 0.024128845743245 no 159 0.0321987332977827 256 767053 SGTC_2334 9017922 200 µM 1.84852759034824 0.0241827251972862 no 160 0.032263028423275 251 3163164 SGTC_1077 5-fluorocytosine 377 nM 1.84771931230273 0.0242317178075629 no 161 0.0323214793476119 243 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2705 st078069 42.8 µM 1.84605991163273 0.0243325612646544 no 162 0.032441753398697 228 1530061 SGTC_2707 st078556 66.6 µM 1.84388717613467 0.0244651331393658 no 163 0.0325997921875014 229 17250899 SGTC_1277 0873-0036 22 µM 1.83874381779009 0.0247813788706527 no 164 0.0329764376177276 325 5965735 SGTC_471 1-acyl-paf 4 µM 1.8365084841608 0.0249198862380129 no 165 0.0331412442394518 271 16759367 SGTC_2891 9063876 19.48 µM 1.83270981212913 0.0251567510622472 no 166 0.0334228686611415 158 6472478 SGTC_1499 4480-0877 67.3 µM 1.82700396024572 0.0255160810980748 no 167 0.0338495869770645 204 2861909 SGTC_734 2023-0417 80 µM 1.82133730655912 0.0258771864889588 no 168 0.0342777993945051 279 3935732 SGTC_1422 4031-0024 15.5 µM 1.81673753332641 0.0261734405737844 no 169 0.0346286558631934 264 782427 SGTC_2260 7964312 200 µM 1.80966868244926 0.026634243286584 no 170 0.0351735909524223 235 231951 SGTC_1164 k060-0068 93.7 µM 1.80193547769134 0.027146095959909 no 171 0.0357777788069362 305 5963676 SGTC_198 3454-2873 16.191 µM 1.80119587705797 0.0271954765063237 no 172 0.0358360059970028 269 710957 SGTC_3343 9148379 18.9835 µM 1.80116075094281 0.0271978236170248 no 173 0.0358387733317801 265 1955036 SGTC_1984 st072354 53.1 µM 1.79146653479391 0.0278520770382979 no 174 0.0366092301024609 247 5762938 SGTC_1785 bathophenanthroline 24 µM 1.78988466253527 0.0279600704537457 no 175 0.0367362274937661 337 72812 An iron chelator. SGTC_2569 tetrandrine 100 µM 1.78501654373467 0.0282946040950381 no 176 0.0371293167350251 251 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_697 0508-1955 564 µM 1.7826156194669 0.0284608165990155 no 177 0.0373244477370303 321 6243113 SGTC_1173 0443-0020 122 µM 1.77875059684081 0.0287300924962789 no 178 0.0376403299711418 316 5331295 SGTC_1450 4112-4260 37.6 µM 1.7693225376678 0.0293958412014554 no 179 0.0384200321997993 309 1633175 SGTC_2041 5107442 45.335 µM 1.76931413934102 0.029396439899148 no 180 0.0384207325675445 310 793005 SGTC_468 gf-109203x 121 µM 1.76368997162142 0.0297996538850625 no 181 0.0388920952201132 174 2396 A protein kinase C inhibitor. SGTC_3351 9150312 21.596 µM 1.76325517854264 0.029831015690939 no 182 0.0389287305824799 312 4904905 SGTC_274 sirtinol 40.1 µM 1.76054842946443 0.0300268709745743 no 183 0.0391574318669327 291 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2681 menadione 3.18 µM 1.7587556490459 0.0301571792786351 no 184 0.0393095104069532 304 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1401 3807-4679 7.6 µM 1.75186661229528 0.030662278278425 no 185 0.0398983734014453 265 3291456 SGTC_2563 tomatine 8.54 µM 1.74546688641137 0.0311377587303116 no 186 0.0404518158205242 383 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_193 1273-0060 1.558 µM 1.74509540544289 0.0311655449291521 no 187 0.0404841316107866 205 2847393 YHR072W ERG7 SGTC_1280 0880-0253 10.1 µM 1.74335124587809 0.0312962797172713 no 188 0.0406361394836467 321 6836607 SGTC_33 0986-0033 35.816 µM 1.73787949765515 0.0317093649485755 no 189 0.0411160244918865 256 2848082 SGTC_2644 guaiazulene 100 µM 1.73527200148669 0.0319077950116894 no 190 0.0413463192598633 265 3515 A coloring agent. SGTC_825 1988-2224 89.6 µM 1.72371983497112 0.0327992882670348 no 191 0.0423792162535242 342 1180859 SGTC_464 bw-b 70c 158 µM 1.7212885520025 0.0329895049627772 no 192 0.0425992379079269 360 5353454 SGTC_1988 st071872 53.4 µM 1.71930954115519 0.0331450074973231 no 193 0.0427790117824532 266 16414116 SGTC_3250 9135583 49.47 µM 1.70992501346573 0.0338906473737194 no 194 0.0436398701585301 264 7699353 SGTC_1938 st074717 56.4 µM 1.70888619157148 0.0339740277527248 no 195 0.0437360163972422 262 17250979 SGTC_2801 7907800 81.82 µM 1.67278579067739 0.0369780322712216 no 196 0.0471847365605631 345 6620925 SGTC_3252 9135871 49.47 µM 1.67128560332507 0.0371074219173089 no 197 0.0473326393500248 317 17682838 SGTC_321 4534-3890 65.3 µM 1.67114822627219 0.037119289019804 no 198 0.0473462018392426 295 699746 SGTC_3190 9110366 49.47 µM 1.67088003153276 0.0371424655421158 no 199 0.0473726882213713 264 17123768 SGTC_213 1246-0773 967 nM 1.66839205450747 0.0373580326550191 no 200 0.0476189622588472 356 6251622 SGTC_2063 5246145 200 µM 1.66481418828047 0.0376698221225188 no 201 0.0479749161874765 363 711240 SGTC_685 1278-0033 54.9 µM 1.66226958178653 0.0378928593442721 no 202 0.0482293669728908 362 3590572 SGTC_863 0466-0191 129 µM 1.65893852786956 0.0381864568209713 no 203 0.0485640899950851 404 765160 YPR165W RHO1 SGTC_1330 1469-0054 61.8 µM 1.65204331651472 0.038800092578845 no 204 0.0492628604246759 323 7102664 SGTC_294 k038-0071 157 µM 1.65146281048565 0.0388521189120856 no 205 0.0493220542708519 387 24152826 SGTC_2368 9071271 200 µM 1.64948346420687 0.0390299399315748 no 206 0.0495243140419244 356 27209959 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.64716929393876 0.0392386805963546 no 207 0.0497616266778395 361 688664 SGTC_1628 st004252 77.7 µM 1.64331232823817 0.0395886014264382 no 208 0.0501591644392788 363 692968 SGTC_2422 chlorphenesin carbamate 384.24 µM 1.63924517160802 0.0399603364516613 no 209 0.0505811048445688 428 2724 A muscle relaxant with antifungal properties. SGTC_2024 5144227 134 µM 1.63759863226738 0.0401116333433673 no 210 0.0507527242880655 396 3475211 SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.6366912451791 0.0401952098618406 no 211 0.0508474995937726 353 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1587 estradiol valerate 56.1 µM 1.62935313501454 0.0408763093333405 no 212 0.0516191418835573 363 13791 A steroid. SGTC_1383 3049-0032 20.7 µM 1.62603167269376 0.0411876597699188 no 213 0.0519714588936613 367 712864 SGTC_2518 prenyletin 46.28 µM 1.6251877494981 0.0412670738337166 no 214 0.0520612799599681 256 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1198 1612-1005 86.7 µM 1.62170766606211 0.0415958655855422 no 215 0.0524329782996766 363 6998509 SGTC_3152 9099253 49.47 µM 1.61030336313469 0.0426882209625169 no 216 0.0536658227019293 503 25236131 SGTC_16 erodoxin 22.806 µM 1.60466008461929 0.0432372740549827 no 217 0.054284315343797 461 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2479 5617353 43.85 µM 1.60390711764874 0.043310962012528 no 218 0.0543672638435707 381 2731746 SGTC_3025 9087895 49.47 µM 1.60189641532415 0.0435082333499099 no 219 0.0545892586639304 371 17173641 SGTC_1219 1469-0211 33.1 µM 1.59929460312963 0.0437645745992162 no 220 0.0548775790733332 331 6822282 SGTC_2676 harmalol 100 µM 1.5938658622377 0.044303360023246 no 221 0.0554830409839833 382 5459187 A monoamine oxidase inhibitor SGTC_2346 9031566 143.75 µM 1.58756521143659 0.044935368813636 no 222 0.0561923450122532 341 4771086 SGTC_1043 0916-0009 19.3 µM 1.58354254184588 0.0453426588840099 no 223 0.0566489291429978 466 3101130 SGTC_2585 alliin 100 µM 1.57991171172423 0.0457128204787535 no 224 0.0570635433742657 414 87310 A garlic compound which reacts with lipids. SGTC_2879 9041815 71.43 µM 1.57421784894525 0.0462981948327039 no 225 0.0577185471389944 242 4942971 SGTC_115 0527-0192 112.043 µM 1.5728107922046 0.0464437750309013 no 226 0.0578813179776384 493 4233931 SGTC_2861 9024595 19.48 µM 1.57169081157355 0.0465599155405613 no 227 0.0580111370749439 251 16482810 SGTC_492 tmb-8 126 µM 1.57150274987359 0.0465794401251911 no 228 0.0580329580867214 208 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_32 0928-0142 34.1 µM 1.56243934133884 0.0475282188476963 no 229 0.0590922626141279 334 2244242 SGTC_1089 terbinafine 2.25 µM 1.55980451404656 0.0478069244505311 no 230 0.0594030422084594 368 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3061 glucosamine 200 µM 1.55122790804673 0.0487232089131773 no 231 0.0604235381645045 341 91431 and experimental redox chemotherapeutic SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.54619376503975 0.0492675373347678 no 232 0.0610288894334875 433 688761 SGTC_2669 eugenol 100 µM 1.54308013994249 0.0496066285510993 no 233 0.0614056663660852 313 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2205 7238770 200 µM 1.54217181808833 0.0497059000215865 no 234 0.0615159232376377 339 279867 SGTC_281 1672-3440 14.9 µM 1.53913653955602 0.0500387790904148 no 235 0.0618854831299551 424 6833000 SGTC_3006 9075424 71.4286 µM 1.53753151894331 0.0502155188804798 no 236 0.0620816013613928 389 7465181 SGTC_65 0798-0905 34.986 µM 1.53144493354139 0.0508902800454972 no 237 0.0628297330477213 533 3602145 SGTC_746 1095-0025 46.6 µM 1.53124855785543 0.0509121699460494 no 238 0.0628539870011207 419 6749286 SGTC_1027 k015-0025 8.67 µM 1.52984495913154 0.0510688467324679 no 239 0.0630275550303037 422 3598955 SGTC_2015 5119600 184 µM 1.52913020228972 0.0511487788320998 no 240 0.0631160847019806 402 2828786 SGTC_1257 0669-0121 16 µM 1.52711658328859 0.0513744995921686 no 241 0.0633660119882778 473 4307855 SGTC_1267 0828-0272 9.49 µM 1.52663611776186 0.0514284752736962 no 242 0.0634257603197905 450 745334 SGTC_112 phenothiazine 287.218 µM 1.52654597900901 0.0514386065184264 no 243 0.0634369744155194 403 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2088 5278280 127.392 µM 1.52525763284773 0.0515835851547227 no 244 0.0635974253236295 450 791502 SGTC_2771 fluoxetine 41.05 µM 1.5250423317797 0.0516078448116795 no 245 0.0636242697334823 377 3386 A selective serotonin reuptake inhibitor. SGTC_1754 st042065 16.137 µM 1.51848862825744 0.0523506520265674 no 246 0.0644456320517977 588 1126236 YIL048W NEO1 SGTC_3356 9151811 4.48 µM 1.51793041655443 0.0524143109497048 no 247 0.0645159705793325 398 1859254 YPR165W RHO1 SGTC_889 0919-1524 82.7 µM 1.51491239546123 0.0527595535761513 no 248 0.0648972954337585 398 3905452 SGTC_617 3770-0098 35 µM 1.51413984540774 0.0528482178498771 no 249 0.0649951873148104 396 5962639 SGTC_2919 7978188 46.38 µM 1.5049996885122 0.0539062136443639 no 250 0.0661620784100351 429 2980291 SGTC_2965 9082772 38.63 µM 1.50283215977505 0.054159554224999 no 251 0.0664411652888962 450 16459634 SGTC_822 1487-0950 154 µM 1.49806092839398 0.0547205348959469 no 252 0.0670587105972301 406 1958375 SGTC_2876 9059903 25.97 µM 1.49599727161708 0.0549645894132671 no 253 0.0673271830861034 434 6916095 SGTC_535 2293-4129 48.2 µM 1.49470363359317 0.0551180171774032 no 254 0.0674959027875472 523 396118 YIL048W NEO1 SGTC_681 1642-0006 26.6 µM 1.49032283441208 0.0556401018402645 no 255 0.0680696856404836 355 4446530 SGTC_2863 9028737 58.44 µM 1.48873279485102 0.0558305584424678 no 256 0.0682788727716868 354 6460917 SGTC_2403 6032726 181.2 µM 1.48255636904702 0.0565752609788332 no 257 0.0690961582920111 427 2881040 SGTC_2221 6807166 181.081 µM 1.47702880214267 0.0572483459156556 no 258 0.0698339584135273 327 674925 SGTC_818 4072-2707 53.5 µM 1.47673756796532 0.0572839831559264 no 259 0.0698729988201306 383 882871 SGTC_3195 9113082 49.47 µM 1.47374769064481 0.057650853652092 no 260 0.0702747685579042 390 17018038 SGTC_83 0170-0301 39.027 µM 1.47205891110715 0.0578588891005217 no 261 0.0705024849405508 286 3089716 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.46894760667035 0.05824370561588 no 262 0.0709235003220823 423 97141 SGTC_816 0325-0417 81.3 µM 1.46739047295923 0.0584370505774173 no 263 0.071134932328545 390 68101 SGTC_596 1155-0152 116 µM 1.46549528562903 0.0586730503487281 no 264 0.0713929188258357 508 280313 SGTC_1689 st020265 53.493 µM 1.46140238073135 0.0591852748976719 no 265 0.0719525238723792 416 5758320 YPR016C TIF6 SGTC_1372 2752-0194 270 µM 1.4556667500647 0.0599089784913156 no 266 0.0727423828848928 429 823334 SGTC_2327 6189656 200 µM 1.45553507964838 0.0599256732657177 no 267 0.0727605929853464 413 5349088 SGTC_556 4058-0063 51.5 µM 1.45238459439384 0.0603262176686 no 268 0.0731973487258833 483 6615692 SGTC_391 gliotoxin 8.33 µM 1.45143924757541 0.0604468143945074 no 269 0.0733287938238787 482 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2396 5342950 42.78 µM 1.44495292337645 0.0612793612285044 no 270 0.0742355546425658 502 1886677 SGTC_1015 4130-4525 82 µM 1.44460839120673 0.0613238327178466 no 271 0.0742839572345334 467 1363237 SGTC_2980 9014342 25.29 µM 1.44410323804606 0.0613890824094967 no 272 0.0743549686958107 450 2996599 SGTC_161 4065-0411 162.148 µM 1.44243739202924 0.0616046410060405 no 273 0.0745895108614307 531 1906281 YLR208W SEC13 SGTC_1503 4585-0012 61.3 µM 1.4417721975101 0.0616908813753771 no 274 0.0746833242775728 416 2922052 SGTC_628 1636-0253 16 µM 1.44108658531774 0.0617798674452021 no 275 0.0747801114329704 483 4456143 SGTC_2229 7354935 190 µM 1.43842081404097 0.062126812198527 no 276 0.0751573452241513 374 318112 SGTC_2736 butenafine 14.65 µM 1.43522642984216 0.0625445547634261 no 277 0.0756112922319407 505 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_532 1548-0774 215 µM 1.43245379798043 0.0629089153781175 no 278 0.0760069957929287 481 5932993 SGTC_1895 st058434 18.3 µM 1.43227478614339 0.0629324966201955 no 279 0.0760325980283281 459 5393175 SGTC_3034 9090421 49.47 µM 1.43195232543098 0.062974991766601 no 280 0.0760787328566523 407 17173761 SGTC_2810 7959871 45.46 µM 1.43053325420065 0.0631622682620675 no 281 0.0762820143055367 534 2974535 SGTC_1913 st060213 96.1 µM 1.42812105983152 0.0634816032023408 no 282 0.0766285084077959 502 688959 SGTC_1031 k035-0009 16 µM 1.42687139759467 0.0636475313343538 no 283 0.0768084833040815 508 5180959 SGTC_1961 st076550 68.7 µM 1.42585090729946 0.0637832805165512 no 284 0.0769556913574885 416 1579337 SGTC_790 1575-0012 79.1 µM 1.42446541659803 0.0639679436465705 no 285 0.077155894649211 475 378741 YLR208W SEC13 SGTC_2305 7443522 69.23 µM 1.42338031316774 0.0641128601811248 no 286 0.0773129681641114 475 5415886 SGTC_1643 st009866 20.2 µM 1.42102037043599 0.0644289136922006 no 287 0.0776554187695197 405 3156273 YOR207C RET1 SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.42048996463445 0.0645001142175128 no 288 0.0777325440587631 528 165506 SGTC_183 3914-0051 30.55 µM 1.42002700644471 0.0645623106705179 no 289 0.0777999094322948 468 1596232 SGTC_2461 5755302 26.15 µM 1.41791650816952 0.0648464375462404 no 290 0.078107571063425 511 2788904 SGTC_891 0929-0073 133 µM 1.41200759620025 0.0656470925766487 no 291 0.0789738622659443 451 5603632 SGTC_1156 4092-0367 4.88 µM 1.40966253627761 0.0659669635164065 no 292 0.0793196759468756 493 1357585 SGTC_1090 efavirenz 20.7 µM 1.40763081270718 0.0662450700174492 no 293 0.0796202092791641 476 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2309 7664088 163.95 µM 1.40190396431263 0.0670338606205171 no 294 0.0804719632589536 535 704922 SGTC_1997 st073024 93.8 µM 1.40036028004069 0.0672477188772842 no 295 0.0807027290196547 464 686268 SGTC_1604 st002052 72.4 µM 1.39669750899332 0.0677572606680007 no 296 0.0812522768005269 478 6254834 YHR062C RPP1 SGTC_1354 1498-1681 81 µM 1.3958988202707 0.0678687642810386 no 297 0.0813724829878391 522 5754243 SGTC_1886 st057356 49.9 µM 1.39554559022087 0.0679181233170144 no 298 0.0814256884348485 463 24207747 SGTC_600 1495-0418 41.6 µM 1.39401238460797 0.0681326890389634 no 299 0.0816569324144592 466 5377768 SGTC_1215 3852-0577 11.2 µM 1.3929347115783 0.068283817760886 no 300 0.0818197672879433 537 2884876 SGTC_2886 9058944 51.95 µM 1.38933195728458 0.0687909326683416 no 301 0.0823659152375569 290 4949929 SGTC_1486 3970-0793 4.53 µM 1.38800974315092 0.0689777709958071 no 302 0.082567039141093 478 2844330 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.38617518634632 0.0692376545487737 no 303 0.0828467082223097 419 17037758 SGTC_2665 lovastatin 100 µM 1.38184678347125 0.0698538057446146 no 304 0.0835093754069552 474 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2212 7123476 200 µM 1.37749331485198 0.0704777729434161 no 305 0.0841798901214794 390 1085715 SGTC_2702 st077768 96.8 µM 1.37749242375924 0.0704779010977317 no 306 0.0841800277786968 460 6484119 SGTC_1950 st077106 7.18 µM 1.37670282990303 0.0705915285696256 no 307 0.0843020717329215 498 13831864 SGTC_69 0096-0274 206.684 µM 1.37150354898716 0.0713432566389232 no 308 0.0851090189736981 576 6741392 SGTC_2921 7974240 10.71 µM 1.37043945414649 0.0714978614937915 no 309 0.0852748815979745 502 2979074 YDR527W RBA50 SGTC_984 1492-0255 2.91 µM 1.36116998340324 0.0728555387941218 no 310 0.0867299888121533 467 1585198 SGTC_2268 7933382 153.85 µM 1.36078493942156 0.0729123593058923 no 311 0.0867908313519913 581 935025 YOR257W CDC31 SGTC_101 0490-5701 117.494 µM 1.3578050985236 0.0733532388025851 no 312 0.0872627683482847 447 4661669 SGTC_237 nikkomycin 200 µM 1.35707164486143 0.0734620683227178 no 313 0.087379223524005 524 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1349 flufenamic acid 69 µM 1.35690352805353 0.0734870308045849 no 314 0.087405932851154 481 3371 A non-steroidal anti-inflammatory. SGTC_2890 9046729 58.44 µM 1.35378589353373 0.0739511227582744 no 315 0.0879023477118053 443 903329 SGTC_2978 9011784 42.97 µM 1.35163667875632 0.0742723572607402 no 316 0.0882457853507878 597 2994934 SGTC_2794 7785382 27.27 µM 1.35023552473434 0.0744823552440813 no 317 0.0884702232018679 606 2205081 SGTC_1195 1502-0147 41.1 µM 1.34570732942175 0.0751641185279076 no 318 0.089198460849568 546 817940 SGTC_2994 9053520 71.4286 µM 1.34214157437434 0.0757043177902741 no 319 0.0897750480188519 518 4647384 SGTC_3207 9114163 49.47 µM 1.34171261207158 0.0757695028493646 no 320 0.0898445980491421 581 849233 SGTC_2218 6965428 192.983 µM 1.34106843787334 0.0758674717741611 no 321 0.0899491167900412 526 675684 SGTC_2296 7971656 126.45 µM 1.33881837651628 0.0762104283237483 no 322 0.0903149034371307 526 666570 SGTC_2847 9005661 71.43 µM 1.33872664047559 0.0762244358137927 no 323 0.0903298401313175 369 2991449 SGTC_2075 5212009 200 µM 1.33697189088116 0.07649275189486 no 324 0.0906159061686064 449 780898 SGTC_3118 9124250 49.47 µM 1.33445624643111 0.0768786678174872 no 325 0.0910271885052937 472 1504786 SGTC_1270 0831-1170 17.3 µM 1.33023099767212 0.0775301761384321 no 326 0.0917210870049447 574 6764716 SGTC_2362 9071156 126 µM 1.32917911930569 0.0776930194824726 no 327 0.0918944411349095 516 653133 SGTC_1405 3909-7894 12 µM 1.32907181908365 0.0777096454226194 no 328 0.0919121383082699 522 7104060 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.3240498467941 0.078490814227407 no 329 0.0927432452403153 562 6728940 SGTC_2020 4017018 200 µM 1.32302571663052 0.078650846150475 no 330 0.092913412916294 522 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_667 1498-1044 59 µM 1.32006079680859 0.079115542623396 no 331 0.0934073601613404 537 6739982 SGTC_3298 9116858 71.43 µM 1.31964730449174 0.079180514770331 no 332 0.093476400644713 553 2506942 SGTC_511 blebbistatin 171 µM 1.31881415512693 0.0793115504302846 no 333 0.0936156253989937 516 3476986 A myosin inhibitor. SGTC_2730 imipramine 71.33 µM 1.31428515320904 0.080026733658251 no 334 0.0943751308237895 629 3696 A tricyclic antidepressant. SGTC_1709 st033179 39.1045 µM 1.31237846892602 0.0803292760837442 no 335 0.0946962339665792 554 573381 SGTC_2308 7584454 197.62 µM 1.31092570256755 0.0805603728018661 no 336 0.0949414331280717 602 893577 SGTC_864 0469-0573 172 µM 1.30981779970754 0.0807369481101589 no 337 0.0951287400625929 525 689425 SGTC_3164 9100705 49.47 µM 1.30933090657758 0.0808146405258473 no 338 0.0952111423860645 466 17174235 SGTC_1747 st037496 66.6 µM 1.30913945963038 0.0808452047309094 no 339 0.0952435574683685 571 723305 SGTC_597 k018-0003 82.8 µM 1.30901486529958 0.0808651007080499 no 340 0.0952646576798797 590 6786234 SGTC_2753 fluvastatin 17.09 µM 1.30535264459634 0.0814515587711879 no 341 0.095886397786354 557 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_3333 9141820 12.094 µM 1.30533147230571 0.0814549585453572 no 342 0.0958900008907382 487 1939433 SGTC_2898 9056270 58.44 µM 1.30401780363829 0.0816661123680276 no 343 0.0961137560854234 468 19154699 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.3013787038728 0.0820915575133702 no 344 0.0965644297244239 508 616764 SGTC_2565 isoliquiritigenin 100 µM 1.30068919253768 0.0822029871860186 no 345 0.0966824315328576 436 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_831 k061-1017 217 µM 1.29875830608085 0.082515637626404 no 346 0.097013443702874 719 1240153 SGTC_453 enantio-paf c16 10 µM 1.2970226899557 0.0827974329692998 no 347 0.0973116899342145 722 13871343 A lipid and platelet activating factor SGTC_1255 0566-0045 221 µM 1.29574407003949 0.0830054929896801 no 348 0.0975318364188375 571 2788469 SGTC_1239 0337-0584 35.4 µM 1.29364837295268 0.0833473598418482 no 349 0.0978934528085112 606 914301 YML130C ERO1 SGTC_739 1486-1183 203 µM 1.29221555896084 0.0835817003791885 no 350 0.0981412524707195 566 4346692 SGTC_988 1497-1057 103 µM 1.29208499029465 0.0836030798203403 no 351 0.0981638566444428 550 3533044 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.28849288197698 0.0841928678676166 no 352 0.0987872225277966 477 61125 An anti-inflammatory. SGTC_1795 st049545 62.3 µM 1.28739155427732 0.0843743188862493 no 353 0.0989789232949935 527 5291882 SGTC_742 0kpi-0133 140 µM 1.28506074208301 0.0847593030281876 no 354 0.0993855293650336 582 2728852 SGTC_1151 3909-8316 15.3 µM 1.28446196853877 0.0848584157870088 no 355 0.0994901812098042 558 800431 SGTC_37 0566-0070 1.56 µM 1.28337119534721 0.0850391907002078 no 356 0.0996810302362544 606 1626686 SGTC_2455 5377712 9.75 µM 1.28206549962932 0.0852559643021688 no 357 0.0999098351254208 503 2243908 SGTC_577 r071-0003 38.6 µM 1.27937004667853 0.0857047766076607 no 358 0.100383388293347 701 4568517 YMR134W ERG29 SGTC_1641 st009299 47.1 µM 1.27681030328313 0.0861326275345211 no 359 0.100834613555909 487 4046054 SGTC_943 3253-1379 105 µM 1.27667686794546 0.0861549744585578 no 360 0.100858175700327 563 668464 SGTC_751 0833-0568 350 µM 1.2761692774761 0.0862400221971618 no 361 0.100947843210951 565 6954252 SGTC_3162 9099653 49.47 µM 1.27400695662363 0.086603026726844 no 362 0.101330475377937 495 25237511 SGTC_1058 3448-5425 97.3 µM 1.26696813390307 0.0877925953445092 no 363 0.102583342174009 558 7279705 SGTC_1828 st055811 49 µM 1.26668636660856 0.0878404667825001 no 364 0.102633728375685 506 5877589 SGTC_2902 5787006 60.46 µM 1.26586345375928 0.0879803887269694 no 365 0.102780986310956 545 591003 SGTC_1665 st014639 11.4 µM 1.2590376114665 0.0891474164548955 no 366 0.104008373523009 626 981133 YIL048W NEO1 SGTC_1248 0469-0687 58.6 µM 1.25752970703199 0.0894067723831254 no 367 0.104280944436355 595 4017482 SGTC_767 0929-0023 86 µM 1.25612624501881 0.0896486683721807 no 368 0.104535101023874 675 1204563 SGTC_1368 1852-0141 284 µM 1.25517907959461 0.089812193417786 no 369 0.104706879109589 558 2838987 SGTC_451 chloral hydrate 100 µM 1.25420446104977 0.089980689497741 no 370 0.104883849410787 656 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1419 3993-2473 62.6 µM 1.25323855987469 0.0901479101322404 no 371 0.105059450380221 598 704026 SGTC_1603 st002045 67.8 µM 1.25004437210454 0.09070254460625 no 372 0.105641669367303 576 5887985 SGTC_2709 st078560 56 µM 1.24377483141109 0.091798536146471 no 373 0.106791222969788 582 17250903 SGTC_148 3253-0744 288.01 µM 1.24197998868859 0.0921140952689541 no 374 0.107121972733639 566 6893655 SGTC_2154 5570129 200 µM 1.24061744519859 0.0923541856892054 no 375 0.107373552147752 627 673366 SGTC_2025 5147754 141 µM 1.2394466052403 0.092560866190343 no 376 0.107590075514031 567 315777 YLR208W SEC13 SGTC_1698 5-fluorocytosine 1.055 µM 1.23811678384113 0.0927960254013286 no 377 0.107836380706966 576 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2955 9076254 12.21 µM 1.23793950597411 0.0928274077086492 no 378 0.107869246191195 550 16459619 SGTC_2859 9028643 45.46 µM 1.23734460453464 0.092932776458747 no 379 0.10797958749125 543 17151580 SGTC_338 4055-0136 114 µM 1.23509840055139 0.0933314206319415 no 380 0.108396942303212 589 2900563 SGTC_567 1080-0542 68.4 µM 1.22990419286166 0.0942580964671526 no 381 0.109366491972278 530 5950415 SGTC_717 1532-0246 73.2 µM 1.22750165850542 0.0946890103404534 no 382 0.109817049420768 613 9561992 SGTC_1820 st053765 18.6 µM 1.22598886990779 0.0949610850771463 no 383 0.110101431738871 568 3690829 SGTC_792 4534-1957 155 µM 1.21766501134122 0.096468437758327 no 384 0.111675649155678 604 1717904 SGTC_396 dithiazanine 1.25 µM 1.21562715057246 0.0968401348092809 no 385 0.112063493312243 576 10578 An antihelmenthic. SGTC_2130 NSC 7 2.4545 µM 1.21531812300066 0.0968965918127416 no 386 0.112122391192748 647 21448 SGTC_1456 k015-0012 13 µM 1.21418329925702 0.0971041228516751 no 387 0.112338868228877 692 2989616 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.2128028084464 0.0973570198581066 no 388 0.1126026107117 408 4000243 SGTC_2125 5246583 200 µM 1.21250413672234 0.0974117981114432 no 389 0.112659730025443 706 835267 SGTC_659 k018-0002 107 µM 1.21129267298184 0.0976342199446378 no 390 0.112891627935971 626 6797879 YHR007C ERG11 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.21081915348176 0.0977212581362144 no 391 0.112982361410101 640 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1470 k295-0292 231 µM 1.20984357202469 0.097900760252311 no 392 0.113169461579911 629 5045612 SGTC_918 glabranin 770.725 nM 1.20896725392825 0.0980622043298586 no 393 0.1133377130833 626 124049 Also referred to as licorice root. SGTC_936 3005-4620 401 µM 1.20663236332173 0.0984933133467053 no 394 0.11378687871131 688 777207 SGTC_793 0488-0545 106 µM 1.20582915939775 0.0986419354492693 no 395 0.113941684876714 623 292548 SGTC_1036 k216-0215 33.5 µM 1.20253422919522 0.0992533360577311 no 396 0.114578306294184 650 622330 SGTC_1284 0929-0043 16 µM 1.20230963331423 0.0992951122683404 no 397 0.114621792984442 632 1239883 SGTC_2398 5228213 48.84 µM 1.19916537069611 0.0998813147759484 no 398 0.115231824764587 715 80771 YMR134W ERG29 SGTC_62 0180-0423 3.232 µM 1.19627549816478 0.100422315460697 no 399 0.115794533512032 605 30102 YGL099W LSG1 SGTC_284 0988-0104 32.6 µM 1.1945667006623 0.100743216437845 no 400 0.116128182966308 642 4666532 SGTC_952 1185-0122 232 µM 1.18842044926955 0.10190362405526 no 401 0.117333901911564 620 678600 SGTC_545 4218-0007 221 µM 1.18814999153548 0.101954908799771 no 402 0.117387160891116 609 2840508 SGTC_642 0335-0876 158 µM 1.18789749364143 0.102002804914027 no 403 0.117436898639504 641 6812350 SGTC_171 k064-0041 9.68 µM 1.18535413778842 0.102486165279977 no 404 0.117938728356758 526 53325 SGTC_24 0417-1663 219 µM 1.18419805504396 0.102706426491998 no 405 0.118167335938063 608 4329390 SGTC_833 3852-0053 558 µM 1.18323613112875 0.10288995790097 no 406 0.118357788617414 713 3123681 SGTC_381 3461-2219 42.7 µM 1.18252072552312 0.103026608983137 no 407 0.11849957342231 683 2883159 SGTC_2099 5377090 177.372 µM 1.1812440892908 0.103270789308459 no 408 0.118752885550245 628 2243829 SGTC_227 fluconazole 33.516 µM 1.18037594035927 0.103437078726991 no 409 0.118925363364238 672 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1138 3761-0006 1.03 µM 1.18007175172067 0.103495390437034 no 410 0.118985839288249 626 12061087 SGTC_2076 5212012 200 µM 1.17985570060844 0.103536821034091 no 411 0.119028805725438 527 604802 SGTC_715 0868-0130 184 µM 1.17406522878113 0.104651706838187 no 412 0.120184449784633 605 2876258 SGTC_3150 9097574 49.47 µM 1.17337942346883 0.104784324147287 no 413 0.120321842479423 614 17217476 SGTC_2537 larixol 68.93 µM 1.1733137111616 0.104797037622689 no 414 0.120335012941701 697 6708759 SGTC_1326 1431-2094 10.8 µM 1.173219756788 0.104815217080403 no 415 0.120353845615505 653 616278 SGTC_1226 3909-7979 35.4 µM 1.17166681331784 0.105116030712749 no 416 0.120665425980394 690 6615510 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.17070274062319 0.105303090916384 no 417 0.12085914161669 730 368090 SGTC_2347 9049783 174.81 µM 1.16788383076806 0.10585142878429 no 418 0.121426813571425 696 6467988 YPL169C MEX67 SGTC_2467 5474540 200 µM 1.16274961064396 0.106855440526417 no 419 0.122465553412784 651 5413519 SGTC_1291 0993-0025 5.79 µM 1.16129330806205 0.107141471615403 no 420 0.122761319999887 668 4353356 SGTC_762 1165-0429 115 µM 1.16118035903573 0.107163678883129 no 421 0.122784280207127 649 5967793 SGTC_3132 9126706 49.47 µM 1.16020717542407 0.107355157127528 no 422 0.122982233130361 620 850858 SGTC_2976 9009005 19.48 µM 1.15853918316047 0.107683915483782 no 423 0.123322035562591 648 2993148 SGTC_1071 trifluoperazine 6.31 µM 1.15661942695557 0.108063193153393 no 424 0.123713940802484 681 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_285 1486-1325 46 µM 1.1541883589675 0.108544867306418 no 425 0.12421147704956 693 22310230 SGTC_2556 citropten 84.59 µM 1.15304778219739 0.108771384419587 no 426 0.124445386367594 693 2775 A potential DNA crosslinker. SGTC_192 3455-0609 60.9 µM 1.14813272018244 0.109751397910249 no 427 0.125456889223159 655 3769639 SGTC_2940 9060638 45.86 µM 1.14653683142699 0.11007096092441 no 428 0.125786548303299 668 4027022 SGTC_3205 9113483 49.47 µM 1.14591583250993 0.110195490866323 no 429 0.12591498978533 699 17018033 SGTC_2148 5546263 113.568 µM 1.14322372305534 0.110736512629043 no 430 0.12647285753217 648 792097 SGTC_3292 9120825 59.784 µM 1.13877297793013 0.111635129799482 no 431 0.127398927603768 681 24824900 SGTC_1563 conessine 56.1 µM 1.13678279333121 0.11203863686979 no 432 0.127814549080186 778 441082 An anti-amoebic, histamine inhibitor. SGTC_1992 st073643 23.3 µM 1.13607976174983 0.112181424438595 no 433 0.127961592109893 647 3161292 SGTC_1315 1237-0019 3.69 µM 1.13363262226788 0.112679459129534 no 434 0.128474341554295 700 825140 SGTC_1165 k072-0275 30.3 µM 1.1327485411643 0.112859772415885 no 435 0.128659933390489 663 6153523 YGL055W OLE1 SGTC_604 1000-0114 314 µM 1.13246822187305 0.112916988091367 no 436 0.128718818595695 735 1572745 SGTC_3260 9137109 49.47 µM 1.13086805057313 0.113243993826247 no 437 0.129055316215752 559 17478346 SGTC_3342 9147791 14.508 µM 1.13008053177886 0.11340517640211 no 438 0.129221146129752 686 1838168 SGTC_536 3852-0578 10.6 µM 1.12944271658542 0.113535838800374 no 439 0.129355560774181 685 2869208 SGTC_3065 9113888 49.47 µM 1.12701541259411 0.114034076188665 no 440 0.129867982297736 626 16648368 SGTC_2522 biochanin a 4.94 µM 1.12387951430815 0.114680065642089 no 441 0.130532071529858 645 5280373 A possible chelator. SGTC_2641 levomentholum 100 µM 1.12157937045939 0.115155543777679 no 442 0.131020663520747 650 16666 SGTC_1996 st072960 66.8 µM 1.12023583097782 0.115433923421455 no 443 0.131306639373446 728 1719405 SGTC_487 nimodipine 119 µM 1.1154368262499 0.116432174819497 no 444 0.132331637951729 579 4497 L-type voltage-gated calcium channels inhibitor SGTC_1406 3909-7906 11.9 µM 1.1134536467328 0.116846483383461 no 445 0.13275682282333 722 X1406 SGTC_3257 9139206 32.98 µM 1.10758262750462 0.118079128214656 no 446 0.134021054778268 645 4910041 SGTC_701 4424-0219 185 µM 1.10584528279965 0.118445648124532 no 447 0.134396745704559 772 2911779 SGTC_2594 a-mangostin 100 µM 1.10571349142996 0.118473484342998 no 448 0.134425274318457 728 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1548 st061468 90.8 µM 1.10558378830479 0.118500884008451 no 449 0.134453354953543 725 390799 SGTC_1288 0973-0013 65.5 µM 1.10384588068359 0.118868447473758 no 450 0.1348299992434 727 4315430 SGTC_1972 st070201 17.4 µM 1.10166648364996 0.11933052200734 no 451 0.135303346576447 707 2829099 SGTC_1314 1222-0010 41.1 µM 1.1012782628799 0.119412965186168 no 452 0.135387784357682 705 3526027 SGTC_1437 4092-1038 11.6 µM 1.1011504277926 0.119440121241832 no 453 0.135415596313746 746 3977136 SGTC_2679 rapamycin 1 nM 1.09951281437018 0.11978838555359 no 454 0.135772223836287 792 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2312 7706453 155.7 µM 1.09938447262768 0.119815709674073 no 455 0.135800200322425 690 976098 SGTC_1691 st019933 84.6 µM 1.09916040619394 0.119863424236225 no 456 0.135849052751688 691 6176082 SGTC_311 1315-0136 58 µM 1.09657651398446 0.120414627786044 no 457 0.136413279437257 727 6759207 SGTC_842 0271-0008 11.1 µM 1.09647326316198 0.120436690591973 no 458 0.13643585886577 761 1221709 SGTC_297 0986-0032 24 µM 1.09618017025625 0.120499334678312 no 459 0.136499967879624 681 2847425 SGTC_1397 3532-0190 20.1 µM 1.09561817149495 0.12061951741666 no 460 0.136622953029933 623 5322280 SGTC_1477 0139-0234 16 µM 1.09520956289026 0.120706950829871 no 461 0.136712418562407 718 620880 SGTC_2708 st078559 56 µM 1.09368114752227 0.121034394222567 no 462 0.137047422718755 599 17250902 SGTC_603 3794-0023 45.9 µM 1.09229192520588 0.121332558995383 no 463 0.137352404207783 711 3802260 SGTC_1772 st048439 82.2 µM 1.09043327598687 0.121732282721412 no 464 0.137761165197433 720 2927068 YDL195W SEC31 SGTC_3224 9130643 49.47 µM 1.0884154242475 0.122167291348248 no 465 0.138205877481455 677 17644395 SGTC_249 wiskostatin 11.211 µM 1.08792636265899 0.122272887398817 no 466 0.138313808461737 742 2775510 A n-wasp and actin depolymerizer. SGTC_1742 st038235 28.8875 µM 1.08585793124889 0.122720202581261 no 467 0.138770925772596 718 564103 YBR002C RER2 SGTC_2717 st081029 62.2815 µM 1.08402318962457 0.123117939980588 no 468 0.139177258531929 708 5292846 SGTC_1398 3558-0053 112 µM 1.08358609477302 0.123212827019343 no 469 0.139274179456954 649 4532369 SGTC_2749 bexarotene 57.39 µM 1.08142373126541 0.12368299905163 no 470 0.139754335036704 697 82146 An retinoic acid receptor inhibitor. SGTC_635 k038-0028 24.7 µM 1.08135889048851 0.123697117034966 no 471 0.139768750371576 742 4035102 SGTC_251 melphalan 456.522 µM 1.0794280384724 0.124118044590153 no 472 0.14019847865818 811 460612 A DNA alkylator. SGTC_3344 9148862 3.898 µM 1.07804521953326 0.124420115608269 no 473 0.140506788274745 732 4905352 SGTC_1471 k673-0312 37 µM 1.0777009418966 0.124495401477805 no 474 0.140583619005005 715 24099884 SGTC_3019 9081971 49.47 µM 1.07703728824943 0.124640617646163 no 475 0.140731803748527 763 16451803 SGTC_2944 9067346 25.62 µM 1.07222836583058 0.125696410766615 no 476 0.141808736320758 717 6473075 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.06917301169763 0.126370442611027 no 477 0.142495858640372 772 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3287 9117173 37.0625 µM 1.06718008448222 0.126811450664141 no 478 0.142945261948357 691 2789709 SGTC_2443 5493264 126.67 µM 1.06494746892095 0.127306769794358 no 479 0.143449851122541 743 5340055 SGTC_1366 1683-0113 21.9 µM 1.06384725118712 0.127551354051242 no 480 0.143698951012994 706 708623 SGTC_3149 9097855 49.47 µM 1.06054331192925 0.128287800311988 no 481 0.144448748285825 720 25236625 YMR079W SEC14 SGTC_2065 5221596 34.26 µM 1.05991612105073 0.128427933582195 no 482 0.144591380425887 719 788581 SGTC_2199 6590217 200 µM 1.05528359191783 0.129466270703383 no 483 0.145647821532348 670 703109 SGTC_2363 9053361 176 µM 1.05456423958616 0.129628026923022 no 484 0.145812333036704 753 6469797 YMR079W SEC14 SGTC_2068 5226020 147 µM 1.05318414460046 0.129938751959812 no 485 0.146128301900106 770 1810509 SGTC_430 0958-0115 16.4 µM 1.05178080216749 0.130255239438306 no 486 0.146450064472108 721 6833180 SGTC_1512 0259-0544 12.2 µM 1.05093597750988 0.130446024698565 no 487 0.146643997588359 809 18476 SGTC_2127 5253358 187.912 µM 1.04847000212971 0.131004016634836 no 488 0.147211058093563 669 20612 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.04564262569626 0.131645811846727 no 489 0.147863030697125 751 756377 SGTC_1921 5740136 50 µM 1.04414381036146 0.131986911307854 no 490 0.148209429546529 817 1774243 SGTC_330 1488-0319 80.1 µM 1.04186183376661 0.132507411751267 no 491 0.148737870627919 753 6846614 SGTC_2211 7117706 200 µM 1.04080700592943 0.132748486810771 no 492 0.148982563937513 730 822771 SGTC_1540 guanosine 70.6 µM 1.04050026043288 0.13281864845278 no 493 0.149053771560512 731 6802 Guanosine is a purine nucleoside SGTC_2623 humulene 100 µM 1.0403517676006 0.132852622266055 no 494 0.149088250718017 651 6187145 An anti-inflammatory. SGTC_160 3453-0671 289.699 µM 1.03908869836545 0.13314184297341 no 495 0.149381743289725 822 5322268 SGTC_3040 9091894 49.47 µM 1.03897680391678 0.133167485718544 no 496 0.149407762183095 688 25236966 SGTC_2525 harmine 47.85 µM 1.03762788277686 0.133476884168495 no 497 0.149721665801468 717 5280953 A monoamine oxidase inhibitor SGTC_3007 9078383 71.4286 µM 1.03646334547475 0.133744388360406 no 498 0.149993015608593 771 6496995 SGTC_1902 st060212 70.5 µM 1.03636227494665 0.133767622495527 no 499 0.15001658159177 770 688944 SGTC_109 0132-0036 33.701 µM 1.0356139732385 0.133939728720843 no 500 0.150191135220372 640 67274 A color developer. SGTC_1286 0929-0070 131 µM 1.03288840330271 0.134567884457194 no 501 0.150828063185192 803 1420408 SGTC_1484 3473-2379 286 µM 1.03244130494029 0.134671118917766 no 502 0.15093271530841 897 671917 SGTC_80 0159-0065 512.242 µM 1.03188942304128 0.134798622700986 no 503 0.151061960701664 676 1548079 SGTC_3176 9106582 49.47 µM 1.0287098554767 0.135534825682643 no 504 0.151808018667908 630 17018027 SGTC_2988 9073640 71.4286 µM 1.02637941369477 0.136076167012592 no 505 0.152356388878685 732 9102229 SGTC_3211 9128781 49.47 µM 1.02487984803955 0.136425284595074 no 506 0.152709942154597 735 17194361 SGTC_1096 rimcazole 32.2 µM 1.02242855046666 0.136997295657653 no 507 0.153289056707362 747 18528119 A dopamine reuptake inhibitor. SGTC_1803 st050068 52.4 µM 1.02232088151339 0.137022457759589 no 508 0.153314526616178 919 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_551 k048-0028 34.9 µM 1.02161743490004 0.13718693007941 no 509 0.153481001254267 831 6836383 SGTC_853 0419-0306 21 µM 1.0173985110523 0.138176182808276 no 510 0.154481945025012 710 762713 SGTC_1553 gossypol 38.6 µM 1.01276996446908 0.139267066294957 no 511 0.155585025166043 698 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_798 1287-0182 476 µM 1.01266512663636 0.139291842784778 no 512 0.155610070255015 875 1649755 SGTC_395 anisomycin 6.25 µM 1.01150838928206 0.13956541545045 no 513 0.155886583953165 729 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2271 7849410 118.62 µM 1.01000880668084 0.13992061586129 no 514 0.156245535380574 802 972430 SGTC_1600 coumarin 106 71.1 µM 1.00615646240833 0.140835920448881 no 515 0.157170155823862 828 100336 A hepatotoxic, DNA x-linker. SGTC_1660 st012960 28.1 µM 1.00142177119365 0.141966420898058 no 516 0.158311471489391 767 24207266 SGTC_2645 abamectin 100 µM 1.00025804752768 0.142245220757268 no 517 0.158592822040461 781 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2953 9074162 66.49 µM 0.994846731374451 0.143546505058876 no 518 0.159905406968946 743 16451992 SGTC_1743 st037606 46.3785 µM 0.994404653722442 0.143653167440364 no 519 0.160012951702005 786 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1128 3448-9350 235 µM 0.994382638515377 0.143658480562009 no 520 0.160018308602543 719 619386 SGTC_3300 9124615 50.48 µM 0.989528249381685 0.144833271824925 no 521 0.161202377732322 808 24824903 SGTC_1407 3909-7909 12.3 µM 0.987778867917435 0.145258213903395 no 522 0.161630479563178 843 4411780 SGTC_1675 st018485 24.5 µM 0.985440768780479 0.145827469936954 no 523 0.162203806163531 812 3323024 SGTC_1306 1185-0270 9.02 µM 0.985419891152179 0.145832559749229 no 524 0.162208931535843 855 1548076 SGTC_1176 0848-0131 83.3 µM 0.982849718818608 0.146460061040225 no 525 0.162840703828278 861 6769040 SGTC_2195 6536160 144.242 µM 0.981602258362743 0.14676527787139 no 526 0.163147917236414 740 3834386 SGTC_2815 7968870 71.43 µM 0.979233581416548 0.147345997024474 no 527 0.163732289744974 824 2977326 YHR190W ERG9 SGTC_2286 7945697 125 µM 0.976394061662357 0.148044177700016 no 528 0.164434611565993 795 1245733 SGTC_2843 9000894 45.46 µM 0.972989213678573 0.148884275909018 no 529 0.165279331489523 694 2242070 SGTC_55 0767-0285 6.563 µM 0.971301047621565 0.149301986042627 no 530 0.165699193633206 876 3116166 SGTC_1877 wortmannin 25 µM 0.964814385566652 0.150914282172791 no 531 0.167318894630086 870 312145 A covalent inhibitor of PI 3-kinase. SGTC_1465 k213-0056 144 µM 0.963829403531904 0.15116011467754 no 532 0.167565731212493 810 24048857 YMR208W ERG12 SGTC_2094 5332512 191.667 µM 0.963451620613787 0.151254472649721 no 533 0.167660465849468 887 755774 SGTC_630 4356-0227 183 µM 0.958073325595075 0.152602045845678 no 534 0.169012892532962 811 779312 SGTC_2493 resveratrol 26.09 µM 0.957820770654245 0.152665520627494 no 535 0.169076571798355 785 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_99 0109-0120 622.8 µM 0.956986155687072 0.152875409458984 no 536 0.169287121401568 812 759414 SGTC_2132 5317594 122.667 µM 0.956881049775453 0.152901855035123 no 537 0.169313648559361 782 794577 SGTC_2338 7999974 200 µM 0.956824378289827 0.152916115340315 no 538 0.169327952700619 915 315925 SGTC_1539 benzyladenosine 56 µM 0.95676182267039 0.152931857300151 no 539 0.169343742924711 826 92208 A nucleotide analog. SGTC_1804 st050076 49.1 µM 0.955369060640501 0.153282620529783 no 540 0.169695547213023 850 3895976 SGTC_2839 9003951 25.97 µM 0.954461282227348 0.153511528706235 no 541 0.169925099373373 821 2990634 SGTC_2738 aclarubicin 5.55 µM 0.95236086386592 0.154042044144578 no 542 0.17045700013655 769 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_348 k064-0012 10.7 µM 0.950685201533341 0.154466145189234 no 543 0.170882101313237 802 5066323 SGTC_2754 granisetron 64.02 µM 0.948562418648272 0.155004517271373 no 544 0.17142160625605 838 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2941 9056145 11.23 µM 0.948164174259515 0.155105656365534 no 545 0.171522941154114 786 2119517 SGTC_1985 st071382 65.5 µM 0.946004472758004 0.155654897993735 no 546 0.172073152454099 867 6123237 SGTC_2281 7943571 200 µM 0.945348928537359 0.155821865314345 no 547 0.172240383274414 942 1244024 SGTC_1824 st053723 68.6 µM 0.943681127101263 0.156247187057608 no 548 0.17266631057173 880 675225 SGTC_356 1634-0012 32.5 µM 0.939496215718037 0.157317784820883 no 549 0.17373801713816 903 735457 SGTC_1866 st057638 64 µM 0.937329074178238 0.157874080892003 no 550 0.174294655969967 849 688802 SGTC_2745 rifampicin 24.3 µM 0.935187383488132 0.158425111419106 no 551 0.174845869654328 740 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1734 st037168 69.4 µM 0.934709142952062 0.15854832890179 no 552 0.174969106879472 839 708907 SGTC_1125 tnp00248 1.32998 µM 0.933446830792821 0.158873862284232 no 553 0.175294655226069 995 24207736 SGTC_2236 dapsone 200 µM 0.932991826909315 0.158991309017786 no 554 0.175412094133534 946 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_56 0957-0365 83.25 µM 0.93044904018767 0.15964870651253 no 555 0.176069318749459 861 6752360 SGTC_1711 st032263 62.8 µM 0.929573222303486 0.159875546709853 no 556 0.176296048614028 848 3958979 SGTC_1809 st050081 57.6 µM 0.929285599674398 0.159950088040372 no 557 0.176370548027804 862 5036894 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.926119783963 0.160772054099536 no 558 0.177191866791222 897 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_507 nimesulide 162 µM 0.924132532721522 0.161289426578586 no 559 0.177708658503553 899 4495 A COX2 inhibitor. SGTC_299 1273-0059 1.44 µM 0.923733102471866 0.161393547493833 no 560 0.177812646419124 841 2848077 SGTC_1041 0206-0046 107 µM 0.923229164636506 0.161524973300691 no 561 0.177943896652707 879 50494 SGTC_786 4544-0069 423 µM 0.922983544757142 0.16158905567541 no 562 0.178007890307233 903 748821 YLR208W SEC13 SGTC_519 k048-0011 62.8 µM 0.922396401028432 0.161742308981573 no 563 0.178160923174105 869 6836379 SGTC_442 cape 100 µM 0.922245125323647 0.161781809547523 no 564 0.178200365034663 867 5281787 SGTC_1216 1165-0504 9.65 µM 0.921595682627459 0.16195146109854 no 565 0.178369755662181 903 6304004 SGTC_1142 3253-1408 9.78 µM 0.91945011629442 0.162512763155165 no 566 0.178930093035421 878 256655 SGTC_924 2046-0044 21.3 µM 0.918455790005078 0.162773317813676 no 567 0.179190147114806 911 3623589 SGTC_2395 5646831 180.19 µM 0.917714024691505 0.162967867879095 no 568 0.179384301650712 874 6808628 SGTC_3197 9113331 49.47 µM 0.917478801305852 0.163029593781342 no 569 0.179445898179477 886 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_423 5-fluorouracil 457 µM 0.917059456614494 0.163139673378209 no 570 0.179555742420573 850 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3215 9129942 49.47 µM 0.916129975986327 0.163383837774876 no 571 0.179799363603499 844 17682944 SGTC_2837 9008476 45.46 µM 0.915360028024753 0.163586274350619 no 572 0.180001327699422 891 2992805 SGTC_990 3985-0011 41.3 µM 0.91509743114988 0.16365535418412 no 573 0.180070241724457 831 5399565 YGL099W LSG1 SGTC_660 4031-1742 102 µM 0.913641161226238 0.16403879033107 no 574 0.18045271525363 891 6738706 SGTC_1455 4262-0120 131 µM 0.911216070386176 0.164678609491883 no 575 0.181090769112948 923 1529587 SGTC_2748 diazoxide 86.69 µM 0.910028987893873 0.164992389761478 no 576 0.181403611231634 842 3019 A potassium channel activatior. SGTC_1735 st034310 56.75 µM 0.908702422705337 0.16534349706947 no 577 0.18175361249943 873 871153 SGTC_1507 4075-3230 155 µM 0.907441420314175 0.165677699474414 no 578 0.182086707048247 843 659771 SGTC_496 calpeptin 138 µM 0.905149356206253 0.166286281002395 no 579 0.182693133715708 818 73364 A calpain inhibitor. SGTC_3068 9116768 49.47 µM 0.905052432028659 0.166312047776564 no 580 0.182718805349813 848 41904888 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.904057141779684 0.166576789537444 no 581 0.1829825512605 887 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1350 1495-0454 146 µM 0.902343722219417 0.167033186601975 no 582 0.183437153269009 947 1069057 SGTC_3086 9117350 49.47 µM 0.899782771879578 0.16771683904727 no 583 0.184117932195601 875 2679265 SGTC_2105 5350118 200 µM 0.899447290368082 0.167806530020299 no 584 0.184207229804491 921 2133313 SGTC_1166 k206-0078 225 µM 0.898976759145297 0.167932378551969 no 585 0.18433252000492 925 5404595 SGTC_3254 9136651 49.47 µM 0.895064009195741 0.168981236976032 no 586 0.185376435973198 966 16454030 SGTC_1011 4112-3381 17.4 µM 0.892947427424055 0.169550361429136 no 587 0.185942663513274 904 2877139 SGTC_870 0573-2213 57.6 µM 0.891682204800836 0.169891151807239 no 588 0.186281647191735 918 3916321 SGTC_714 4296-0578 26.1 µM 0.890582829311913 0.17018762724734 no 589 0.186576507123254 928 1589775 SGTC_2747 doxorubicin 7.63 µM 0.890118203127373 0.17031302548592 no 590 0.186701209837933 746 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3216 9129716 49.47 µM 0.888067230772059 0.170867270712747 no 591 0.18725229413118 859 8056934 SGTC_957 1187-1561 14.1 µM 0.885789757620082 0.17148407520842 no 592 0.187865415056454 925 1538454 SGTC_3047 9092122 49.47 µM 0.885398457334984 0.171590193519173 no 593 0.187970882072681 890 17173831 SGTC_548 1436-0017 110 µM 0.885283421035652 0.171621398658479 no 594 0.188001894713889 997 9677137 SGTC_2683 piperine 63.03 µM 0.88435751989414 0.171872693781648 no 595 0.188251623455913 897 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1482 3346-2049 8.48 µM 0.884024191095014 0.171963218707989 no 596 0.188341577068245 917 3826804 SGTC_3136 9095672 49.47 µM 0.882543369807854 0.172365745810612 no 597 0.188741518639633 824 17217380 SGTC_2048 5246248 200 µM 0.880587200556286 0.172898405941048 no 598 0.189270644397704 939 677046 SGTC_639 0833-0042 114 µM 0.876490207909438 0.174017401931966 no 599 0.190381798696253 961 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2740 felodipine 17.08 µM 0.87648010675206 0.174020166500209 no 600 0.190384543194747 884 3333 L-type calcium channel blocker SGTC_1523 st012844 44.7 µM 0.873573380142525 0.174816863411573 no 601 0.191175314127608 924 4274103 SGTC_580 1123-0028 41 µM 0.87147733804765 0.175392796248698 no 602 0.191746787163391 1075 1677248 YPR107C YTH1 SGTC_397 arbidol 50 µM 0.86981819865962 0.175849532544999 no 603 0.192199882235986 985 131410 A RNA synthesis inhibitor. SGTC_2252 omeprazole 400 µM 0.868096834013873 0.176324193984686 no 604 0.192670662054397 870 4594 A proton pump inhibitor. SGTC_122 0236-0016 402.397 µM 0.866390582900772 0.176795487165293 no 605 0.193138003212905 1026 6808838 SGTC_2266 7929956 200 µM 0.86573554019134 0.176976631520086 no 606 0.193317602697798 951 2967153 SGTC_934 2950-0684 338 µM 0.865081020596915 0.177157748307932 no 607 0.193497160511745 994 1121253 SGTC_2568 diosmetin 100 µM 0.865043677194576 0.177168085396596 no 608 0.193507408191194 958 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_254 nsc-64875 3.808 µM 0.864487312695513 0.177322138688153 no 609 0.193660123496167 985 56993 SGTC_1794 st048918 76.9 µM 0.863226281896238 0.177671621972562 no 610 0.194006533109014 891 672303 SGTC_819 1013-0258 27.7 µM 0.862534735634816 0.17786346216193 no 611 0.194196663503677 954 5753198 SGTC_1668 st014914 51.6 µM 0.859290615321868 0.178765148840027 no 612 0.195090100249406 980 2839556 SGTC_2682 pyrogallin 40.03 µM 0.857124397300013 0.179368837510988 no 613 0.19568806955983 1031 822798 An ATP competetive kinase inhibitor. SGTC_1965 Pectolinarigenin 58.4 µM 0.856742799812609 0.179475314974042 no 614 0.195793522018665 985 5320438 An anti-inflammatory. SGTC_1932 st074806 40.9 µM 0.856568973390403 0.179523831073791 no 615 0.195841569467509 1063 17251235 SGTC_3240 9133527 49.47 µM 0.855383762014 0.179854851061996 no 616 0.196169365018697 933 17617455 SGTC_3350 9150499 3.57 µM 0.855007468215616 0.179960027017997 no 617 0.196273506660411 1014 4910996 YPR165W RHO1 SGTC_735 3076-0345 636 µM 0.85309491569554 0.180495191638131 no 618 0.196803335353184 995 2888990 SGTC_2862 9027634 71.43 µM 0.852265167138051 0.1807276795255 no 619 0.197033467235176 881 5012562 SGTC_1946 st076057 65.1 µM 0.852001036375574 0.180801725904709 no 620 0.197106758420537 863 953009 SGTC_539 4859-0462 2.54 µM 0.851188383842832 0.18102966404104 no 621 0.197332357245989 995 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1706 st031321 9.9705 µM 0.850804031189663 0.181137532494133 no 622 0.197439110986485 1001 6103185 SGTC_2017 5132927 60.65 µM 0.849980667960167 0.181368744605335 no 623 0.197667917181737 994 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_29 0299-0004 12.984 µM 0.84940529737036 0.181530426486226 no 624 0.19782790324675 874 16871 A napthoquinone isolated from Swertia calycina. SGTC_35 0133-0054 64.071 µM 0.848354488098925 0.181825941647049 no 625 0.198120290402166 926 99677 SGTC_2115 tiliquinol 12.7705 µM 0.84739980322521 0.18209468483101 no 626 0.198386157071473 952 71208 A bioactive hydroxyquinoline. SGTC_313 3474-0040 5.03 µM 0.847002213722701 0.182206679226676 no 627 0.198496943775001 962 1043375 YIL048W NEO1 SGTC_1199 1638-0010 4.46 µM 0.846774230531032 0.182270917742409 no 628 0.19856048720069 951 3111136 SGTC_1264 0783-0040 158 µM 0.845885075623374 0.182521588934021 no 629 0.198808429482956 919 2855798 SGTC_1648 st011736 69.8 µM 0.845225253948074 0.182707745445771 no 630 0.198992542409919 962 2855514 SGTC_893 0958-0369 48.9 µM 0.845180976494161 0.18272024175528 no 631 0.199004901019105 1008 6819948 SGTC_944 3370-0224 231 µM 0.84504588367536 0.182758371944248 no 632 0.199042610637833 973 4580514 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.843025264478354 0.183329287994209 no 633 0.199607157090033 1002 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3242 9133940 49.47 µM 0.842902983545244 0.183363873520382 no 634 0.199641352394465 1014 17248444 SGTC_3129 9127257 49.47 µM 0.839646499417406 0.184286422759239 no 635 0.200553309673954 857 837894 SGTC_1967 st070177 51.4 µM 0.837774943424485 0.184817931889806 no 636 0.201078556886098 985 5729214 SGTC_1159 4092-0538 61.2 µM 0.837567165145101 0.184876998208978 no 637 0.201136920148026 1042 717301 SGTC_1227 3909-8010 46.6 µM 0.83705930951417 0.185021418606401 no 638 0.201279615499864 949 15982272 SGTC_3271 9137798 49.47 µM 0.835912369510691 0.185347835108943 no 639 0.201602101581925 917 6498326 SGTC_3095 9117207 49.47 µM 0.835850049463759 0.185365581486985 no 640 0.201619633023375 953 17015229 SGTC_152 4469-0003 551.229 µM 0.8337556408842 0.185962602682679 no 641 0.202209348399891 1004 697280 SGTC_2429 5902844 64.44 µM 0.833532399774839 0.186026308868299 no 642 0.20227226642467 1024 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2650 prasterone 100 µM 0.831895534387165 0.186493833396308 no 643 0.202733956346077 968 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2777 climbazole 1.536 µM 0.831455859745763 0.186619537963591 no 644 0.202858077015608 1010 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1531 st059297 52.4 µM 0.83070983423096 0.186832949345613 no 645 0.203068784725537 1006 7566702 SGTC_1773 st048542 73.5835 µM 0.830015011533992 0.187031849207665 no 646 0.203265148176679 947 3237138 SGTC_1052 3253-3998 198 µM 0.828283376633414 0.187528116547358 no 647 0.203755017420032 1052 5450317 SGTC_1800 st050079 29.0735 µM 0.827005960593058 0.187894730846972 no 648 0.204116841524587 1054 3645560 SGTC_1091 telmisartan 47.6 µM 0.826370259729682 0.188077339757431 no 649 0.204297044338007 1052 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2688 kanamycin b 96.69 µM 0.826331798951996 0.188088391361047 no 650 0.204307949894349 1237 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2022 5136654 200 µM 0.824584262849695 0.188590964060987 no 651 0.20480382945658 975 1713771 SGTC_3144 9087057 49.47 µM 0.821190950817235 0.189569206272319 no 652 0.205768755084932 963 17249618 SGTC_3039 9090270 49.47 µM 0.820617889037694 0.189734719197452 no 653 0.205931977365713 1016 17173750 SGTC_172 1112-0046 2.638 µM 0.819681799082812 0.190005273787632 no 654 0.2061987642488 905 2802135 YIL048W NEO1 SGTC_2215 7188065 200 µM 0.817783683264194 0.190554606591927 no 655 0.206740358314889 1017 940217 SGTC_1258 0671-0043 57.1 µM 0.81773026424172 0.190570080659351 no 656 0.206755612671495 1032 4298767 SGTC_1935 st074532 41.6 µM 0.817518728170531 0.190631364598109 no 657 0.206816025537228 1096 2829742 SGTC_2141 5621638 7.665 µM 0.817029950806421 0.190773014142672 no 658 0.206955656070787 1023 2856238 SGTC_3125 9127534 49.47 µM 0.814890541590031 0.191393782815022 no 659 0.207567483854753 919 1639235 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.814463867461634 0.191517734011862 no 660 0.207689631747596 990 688662 SGTC_911 3456-4043 236 µM 0.813411028168421 0.191823799988133 no 661 0.20799121926555 1041 914281 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.812331783023931 0.192137852913117 no 662 0.208300638970822 995 75037 A free radical scavenger. SGTC_2220 6782180 200 µM 0.811315454306797 0.192433885010188 no 663 0.208592268649739 972 833803 SGTC_1881 5652484 16 µM 0.810724235743458 0.192606220975823 no 664 0.208762026096737 996 2255129 SGTC_3209 9113616 49.47 µM 0.810386975194471 0.192704572243312 no 665 0.208858900666298 1059 16649353 SGTC_1864 st057645 30.4 µM 0.80886188398516 0.193149699412337 no 666 0.209297297744773 1066 688666 SGTC_2920 7982904 15.77 µM 0.807907227135268 0.193428653510062 no 667 0.209571995278563 973 6456808 SGTC_489 paxilline 115 µM 0.807653555534196 0.193502818558983 no 668 0.209645023605555 1014 105008 A toxic potassium channel blocker. SGTC_2080 5212524 12.4 µM 0.806323757896301 0.193891890418127 no 669 0.210028097594346 1015 260183 SGTC_1010 4112-3296 15.2 µM 0.804774243649552 0.194345847879986 no 670 0.210474983629392 1071 704384 SGTC_2470 5664817 21.68 µM 0.804050621300831 0.194558067263502 no 671 0.210683870207638 1039 2859561 SGTC_2600 tangeritin 87.95 µM 0.802532513989845 0.195003746223488 no 672 0.21112249414411 999 68077 A bioactive flavone. SGTC_2583 asiatic acid 100 µM 0.801284253140837 0.195370669505456 no 673 0.211483552449665 1034 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_292 k038-0015 474 µM 0.80120335787433 0.195394462937157 no 674 0.211506963799973 1061 46368540 SGTC_874 0599-0792 117 µM 0.799532578912713 0.195886276619108 no 675 0.211990831839201 1095 765305 SGTC_3327 9140648 26.9345 µM 0.798323805526873 0.196242561323904 no 676 0.212341303451198 1039 8029710 SGTC_1900 st060200 72.8 µM 0.796780648278337 0.196697975865273 no 677 0.212789217971562 1037 688945 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.795575560364933 0.197054064581236 no 678 0.213139388219251 1095 165521 SGTC_2361 9034121 116 µM 0.794223573685239 0.197454024126212 no 679 0.213532643583315 1018 6496917 SGTC_135 0933-0004 26.348 µM 0.791976084414486 0.198119986355115 no 680 0.21418731058486 976 21230617 YGL099W LSG1 SGTC_2800 7887935 81.82 µM 0.791553784019732 0.198245270998029 no 681 0.214310451888392 1007 2961002 SGTC_871 0574-0004 149 µM 0.791234208113002 0.198340111956137 no 682 0.214403666460453 1012 9551173 SGTC_3090 9117696 49.47 µM 0.790573634904703 0.198536237901495 no 683 0.214596418560771 1040 7923821 SGTC_162 k030-0015 37.8 µM 0.7886793946232 0.19909929125625 no 684 0.215149707038124 1110 1809920 YMR134W ERG29 SGTC_3306 9127676 59.7925 µM 0.78619221285503 0.199840052582281 no 685 0.215877443751122 1049 41905287 SGTC_2639 lactacystin 53 µM 0.784967614195115 0.200205384960203 no 686 0.216236278505154 1057 3870 A proteasome inhibitor. SGTC_1525 8-methoxypsoralen 92.5 µM 0.783662504030754 0.200595177683536 no 687 0.216619084805043 1116 4114 Related to psoralen; DNA damaging agent. SGTC_286 k060-0067 22.9 µM 0.783155529613593 0.200746716774524 no 688 0.21676789284634 1030 5985051 SGTC_2572 astragaloside iv 100 µM 0.780890406963782 0.201424620674266 no 689 0.217433477350859 1037 45006101 An anti-inflammatory agent. SGTC_1924 st058459 75.1 µM 0.780022426810136 0.201684752168067 no 690 0.217688837320438 1067 688683 SGTC_1333 1482-0047 286 µM 0.779491747685313 0.201843894455758 no 691 0.217845048445573 1090 3811116 SGTC_2729 fluphenazine 10.66 µM 0.775587557485063 0.203017008984983 no 692 0.218996274658787 1070 3372 An atypical antipsychotic. SGTC_2186 6124449 200 µM 0.775377120934886 0.2030803554942 no 693 0.219058425180988 1046 3834182 YLR033W RSC58 SGTC_2411 st077133 39.94 µM 0.775245871121572 0.203119870848621 no 694 0.219097193755674 1098 1403142 YNL221C POP1 SGTC_1526 st051518 75 µM 0.774520082765826 0.203338466662955 no 695 0.219311648363052 965 673993 SGTC_1693 xanthone 101.9 µM 0.773361307784414 0.203687761937614 no 696 0.219654290996843 1093 7020 An insecticide. SGTC_2122 5258151 111.688 µM 0.771963588300411 0.204109559105853 no 697 0.220067996779854 1049 2173356 SGTC_980 1473-0395 201 µM 0.77165472867953 0.204202835439113 no 698 0.220159475250302 1028 768876 SGTC_712 r015-0009 80.6 µM 0.771586736651008 0.204223372600699 no 699 0.220179616152042 1027 6813872 YLR060W FRS1 SGTC_1720 st037298 9.481 µM 0.770157334938981 0.204655411625375 no 700 0.220603284451715 1046 597396 SGTC_2544 sphondin 68.51 µM 0.769741402424954 0.204781229971419 no 701 0.220726652662841 1075 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3049 9092223 49.47 µM 0.768946753419137 0.205021736795114 no 702 0.220962460403782 1028 8623917 SGTC_1094 duloxetine 25.4 µM 0.768307502801265 0.205215332870499 no 703 0.221152259136558 1087 60834 A selective serotonin reuptake inhibitor. SGTC_3213 9129884 49.47 µM 0.761828843342746 0.207183506200238 no 704 0.223081081615418 1060 17190742 SGTC_2812 7970281 58.44 µM 0.760026680875236 0.207732969478828 no 705 0.223619318341078 1100 2233435 SGTC_359 0081-0058 15.9 µM 0.759628063201494 0.207854620609707 no 706 0.223738469793423 1071 3494159 SGTC_721 1187-1332 279 µM 0.759324517870536 0.207947285537054 no 707 0.22382922722017 1001 25730 SGTC_1272 0839-0021 27 µM 0.759054003577002 0.208029887451365 no 708 0.223910126282762 1097 5027250 SGTC_595 3909-8003 73.7 µM 0.757519411986402 0.208498843589931 no 709 0.22436937026445 1106 699517 SGTC_2316 5844804 197.44 µM 0.756190805757587 0.208905355645858 no 710 0.224767402235345 1200 776813 SGTC_2788 5282734 71.43 µM 0.755265102860149 0.209188867642715 no 711 0.225044966480117 1131 743706 SGTC_1472 k841-0093 193 µM 0.7530786282324 0.209859410764193 no 712 0.22570133312733 1173 X1472 SGTC_1295 1013-0063 9.78 µM 0.752134009814684 0.210149494594836 no 713 0.22598523662121 1123 6826038 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.750684917419965 0.210594955356789 no 714 0.226421151086011 1148 16486 A toxic proline analog. SGTC_671 0560-0003 407 µM 0.75027536861602 0.210720953772752 no 715 0.226544437142381 1055 3238678 SGTC_713 1488-1073 324 µM 0.748594979449567 0.211238391225941 no 716 0.227050679522886 1113 3312542 SGTC_1070 indatraline 8.81 µM 0.746253920795881 0.211960506379601 no 717 0.227757020600667 1099 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1092 toremifene 6.32 µM 0.745612042235603 0.212158750027037 no 718 0.227950903153909 1152 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2294 7971431 200 µM 0.743799104156842 0.212719259527266 no 719 0.228499011109376 1041 5741572 SGTC_2184 6075246 200 µM 0.743753944341609 0.212733232700611 no 720 0.228512673780187 1102 2267320 SGTC_309 k408-0051 1.48 µM 0.739396891719229 0.214083893065181 no 721 0.229833014580337 1126 3640463 SGTC_1514 1189-1591 158 µM 0.737983885670748 0.214522985904744 no 722 0.230262120740154 1140 767698 YMR146C TIF34 SGTC_1969 st069479 40.1 µM 0.737928994093429 0.214540054067553 no 723 0.230278799424727 1096 3895485 SGTC_2593 nobiletin 86.24 µM 0.737585081712687 0.214647009250811 no 724 0.230383311817849 1089 72344 An anti-infammatory. SGTC_2008 4012253 172 µM 0.73567945346143 0.215240212281966 no 725 0.230962898291416 1145 603940 SGTC_2460 5552655 174.22 µM 0.735670489607601 0.2152430048865 no 726 0.230965626520972 1144 5401989 SGTC_1751 st044839 27.194 µM 0.735647269168214 0.215250239094253 no 727 0.230972693954266 1149 5291326 SGTC_2207 7258803 200 µM 0.73507285015768 0.215429241280844 no 728 0.231147564046004 1100 3666799 SGTC_1703 st026983 48.3 µM 0.733683003490827 0.215862706563412 no 729 0.23157097984324 1143 1104023 SGTC_344 k064-0035 6.43 µM 0.732205070998888 0.216324198068095 no 730 0.232021704830425 1119 5088750 SGTC_1023 4482-3888 16 µM 0.730978983649863 0.216707482781035 no 731 0.232395995000192 1129 3303168 SGTC_501 nsc-95397 161 µM 0.730865766539662 0.216742895152181 no 732 0.232430573946611 1126 262093 SGTC_1753 st043925 64 µM 0.730809849007528 0.216760386432084 no 733 0.232447653422137 1156 670181 SGTC_1686 st019653 115.5 µM 0.730457680187337 0.216870565333298 no 734 0.232555236060246 1149 97252 SGTC_2114 5491910 81.25 µM 0.730268604018948 0.216929732716962 no 735 0.232613007599135 1153 2849228 SGTC_3180 9109287 49.47 µM 0.729205304556616 0.217262643503459 no 736 0.232938043449982 1129 18891271 SGTC_2201 6605497 169.863 µM 0.728826795696339 0.217381222860491 no 737 0.233053809199059 1147 670741 SGTC_779 1360-0071 233 µM 0.728444763992356 0.217500943738232 no 738 0.233170684786519 1220 7566 SGTC_1953 st076800 12.1 µM 0.727042159252815 0.217940817457496 no 739 0.233600064856395 1085 297591 SGTC_173 1273-0061 2.693 µM 0.726168419017833 0.218215092009509 no 740 0.233867764855231 1128 2847414 YPL266W DIM1 SGTC_872 0588-0139 234 µM 0.725341596540455 0.218474821744584 no 741 0.234121246471585 1179 2047100 SGTC_2314 7727897 200 µM 0.724599424859136 0.218708111672418 no 742 0.234348905934345 1155 900724 SGTC_2549 cedrol 20.94 µM 0.724299789993625 0.218802337764355 no 743 0.234440852947445 1094 6708665 A sedative which affects the nervous system. SGTC_2412 st077135 33.4 µM 0.723181956513776 0.219154068604119 no 744 0.234784051350376 1169 13258915 SGTC_2778 tioconazole 65.09 nM 0.72284788476659 0.219259248692976 no 745 0.234886672285573 1129 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_565 1418-0001 44.5 µM 0.722543332390249 0.219355160097392 no 746 0.234980246987994 1171 2862145 SGTC_3326 9140064 16.379 µM 0.722406979825891 0.219398108851589 no 747 0.235022148428548 1157 1868434 SGTC_3042 9091578 49.47 µM 0.720873777413959 0.219881374219004 no 748 0.235493588932018 1124 25236497 SGTC_2519 cryptotanshinone 88.04 µM 0.719844285297519 0.220206212649282 no 749 0.235810437433807 1145 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_82 0054-0107 293.755 µM 0.718855616656014 0.220518428823828 no 750 0.236114942736876 1167 3104697 SGTC_386 1509-0011 3.07 µM 0.716060229424292 0.221402568120516 no 751 0.236977079825523 1205 3107280 SGTC_1352 1496-0991 99 µM 0.71530731930856 0.221641048382783 no 752 0.237209583417735 1166 3000039 SGTC_2520 obtusaquinone 4.71 µM 0.714643887681972 0.2218513084169 no 753 0.237414559274412 1216 5967872 SGTC_503 tyrphostin 8 294 µM 0.713578905621205 0.222189069120338 no 754 0.237743802621407 1147 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2969 9091408 28.7 µM 0.713313293899598 0.222273353986991 no 755 0.237825956523741 1102 4286311 SGTC_516 3992-2719 87.3 µM 0.713105304659047 0.222339366614088 no 756 0.237890298617531 1142 5350887 YDR037W KRS1 SGTC_563 tetrahydrosecaminediol 614 µM 0.712814000003158 0.222431841087789 no 757 0.237980430628042 1211 334274 A psychoactive constituent of the cannabis plant. SGTC_800 3448-7362 155 µM 0.712732968608673 0.22245756835041 no 758 0.238005505722793 1269 15991913 SGTC_1196 1588-0294 184 µM 0.712387229915572 0.222567358576166 no 759 0.238112510532533 1141 6144269 SGTC_2049 5262831 67.185 µM 0.710571173780358 0.223144559021975 no 760 0.23867500569937 1201 763417 SGTC_3098 9119039 49.47 µM 0.710418764150625 0.223193038385688 no 761 0.238722245262544 1213 17161528 SGTC_1081 sertraline 6 µM 0.709802872360423 0.223389005977015 no 762 0.238913193819164 1183 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2180 6301957 200 µM 0.705193520398379 0.2248587376309 no 763 0.240344906563121 1160 845462 SGTC_2997 9067075 71.4286 µM 0.7044411501096 0.225099156751846 no 764 0.24057904354224 1174 27209819 SGTC_2914 7968218 45.32 µM 0.702289544297404 0.225787503304184 no 765 0.241249306222232 1112 2977111 SGTC_458 nppb 133 µM 0.701435606348238 0.226061026727652 no 766 0.241515603813116 1201 4549 A chloride channel blocker. SGTC_2761 levamisole 97.89 µM 0.700937027827718 0.226220812130774 no 767 0.241671157577958 1179 26879 An alkaline phosphatase inhibitor. SGTC_1787 fluconazole 80 µM 0.699460674787652 0.226694330637025 no 768 0.242132090426867 1119 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1607 st000305 50.6 µM 0.699308297352779 0.226743235280723 no 769 0.242179691376141 1186 5457690 SGTC_611 3453-1652 23.7 µM 0.698648489823539 0.226955065320186 no 770 0.24238586615091 1199 1560575 SGTC_1378 2093-0007 380 nM 0.698371659533539 0.227043974420308 no 771 0.242472397602487 1194 3618014 SGTC_1476 4112-3294 3.34 µM 0.693751650586137 0.228530670219443 no 772 0.243918984237178 1217 704369 SGTC_991 3996-0057 64.7 µM 0.693441223821805 0.228630759682078 no 773 0.244016349691153 1169 715343 SGTC_1139 k015-0024 46.9 µM 0.692993557611817 0.228775141962492 no 774 0.244156797250326 1191 2766652 SGTC_2409 alverine citrate 63.97 µM 0.692788478260372 0.228841301692912 no 775 0.244221151918119 1233 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2491 paeonol 100 µM 0.692588975541899 0.228905672674473 no 776 0.244283765391984 1144 11092 Increases levels of cortical cytochrome oxidase. SGTC_1475 4092-1048 11.7 µM 0.692193410430669 0.229033334635184 no 777 0.24440793818469 1210 2881759 SGTC_191 3914-0123 66.505 µM 0.690724132582624 0.229507868808637 no 778 0.244869460359741 1132 3144412 SGTC_1854 st056233 32.9 µM 0.689697775994292 0.229839678820363 no 779 0.245192132376854 1154 5393174 SGTC_627 1391-0720 175 µM 0.689298907628257 0.229968701093281 no 780 0.245317592621719 1161 997839 SGTC_2103 5378138 10 µM 0.688519319100562 0.230220992227819 no 781 0.245562904364728 1246 244142 SGTC_134 0269-0018 6.916 µM 0.684074798296985 0.231662285390416 no 782 0.246963967404258 1141 4378915 SGTC_2989 9073649 71.4286 µM 0.684054361296544 0.231668924404516 no 783 0.24697041970194 1210 21367202 SGTC_263 alizarin 107.927 µM 0.683935769969532 0.231707451206004 no 784 0.247007862717696 1220 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_955 1216-0110 33 µM 0.683159408066326 0.231959756308036 no 785 0.247253059622729 1188 3619719 SGTC_408 cantharidin 100 µM 0.682577079356585 0.232149104117195 no 786 0.247437060775341 1187 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2093 5331342 194.4 µM 0.681851680116008 0.232385092480721 no 787 0.24766637091411 1222 33839 SGTC_339 3091-4833 71.4 µM 0.681759145886243 0.23241520549905 no 788 0.247695630603604 1187 3240077 SGTC_993 3909-8757 62.7 µM 0.678004062595873 0.233639035632896 no 789 0.248884558672951 1190 4288324 YLR208W SEC13 SGTC_2453 5731132 22.18 µM 0.677777665489692 0.233712935403676 no 790 0.248956337103319 1268 1362040 SGTC_1293 1000-1278 195 µM 0.674016047867725 0.234942684145406 no 791 0.25015055554727 1276 678847 SGTC_387 norethindrone acetate 66.7 µM 0.672820308094192 0.235334343257055 no 792 0.250530808137564 1223 541197 SGTC_1123 mangostin 811.285 nM 0.672122137249855 0.235563192486408 no 793 0.250752972286548 1208 5281650 An antioxidant. SGTC_2480 5767542 37.17 µM 0.671717956222187 0.235695732649328 no 794 0.250881633931909 1234 2867358 SGTC_1309 pyrazolanthrone 13.4 µM 0.671040436794298 0.235917998920972 no 795 0.251097384868648 1260 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2324 6149169 200 µM 0.6709916190771 0.235934018467862 no 796 0.251112934291405 1164 2888231 SGTC_433 pimozide 108 µM 0.668373283129542 0.236794103955138 no 797 0.251947672603501 1195 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2009 4012297 12.05 µM 0.66712457864683 0.237204891741256 no 798 0.25234628080864 1229 45595307 SGTC_2167 5876490 200 µM 0.666346511109559 0.2374610513582 no 799 0.252594821514556 1292 686534 SGTC_1132 3456-3614 2.5 µM 0.665870427771455 0.237617864953314 no 800 0.252746961968603 1292 3125502 SGTC_1004 4084-0029 199 µM 0.665097456003041 0.237872589430043 no 801 0.252994080854509 1254 716894 YLR208W SEC13 SGTC_2050 5263056 171 µM 0.663118729179738 0.238525339167055 no 802 0.253627258165211 1248 763468 YGL055W OLE1 SGTC_3310 9130229 44.1445 µM 0.662374047869781 0.238771251108794 no 803 0.253865765823747 1260 7761258 SGTC_1417 3966-0327 90.4 µM 0.661915915676492 0.238922606421165 no 804 0.25401255556739 1291 651118 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.661838791739101 0.238948091381864 no 805 0.254037271160769 1363 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_3225 9130819 49.47 µM 0.661197238167487 0.239160144998507 no 806 0.254242916104085 1259 4547121 SGTC_68 0986-0284 82.829 µM 0.65936684592204 0.239765712039777 no 807 0.254830113337133 1223 423278 YIL048W NEO1 SGTC_873 0591-4978 488 µM 0.658272664095911 0.240128110350839 no 808 0.255181470012264 1347 3305145 SGTC_1028 k015-0029 4.8 µM 0.655152834001954 0.241163050553166 no 809 0.256184679112473 1256 4588309 SGTC_1863 st057641 20.1 µM 0.6518604391509 0.242257859918585 no 810 0.257245603895115 1273 3921635 SGTC_1494 4358-1428 177 µM 0.651744884493048 0.242296333804119 no 811 0.257282881090566 1305 1564571 SGTC_744 1594-0068 283 µM 0.650128701611882 0.242834788240584 no 812 0.257804545481317 1285 668392 SGTC_1552 6-methylflavone 10.6 µM 0.649198772808855 0.243144900559848 no 813 0.258104952410931 1240 689013 SGTC_3330 9141424 71.43 µM 0.648521429225097 0.243370915571359 no 814 0.258323877671099 1273 27261020 SGTC_2948 9070189 9.45 µM 0.64692213406037 0.243905016212647 no 815 0.258841169892952 1202 6473636 YDL196W YDL196W SGTC_1340 1486-1359 257 µM 0.646542545040636 0.244031876578084 no 816 0.258964026667734 1246 4309068 SGTC_925 2064-1272 59.6 µM 0.64608491935808 0.244184864455874 no 817 0.259112180672348 1249 6815817 SGTC_760 0568-0725 82.9 µM 0.645777351680046 0.24428771580913 no 818 0.25921177877381 1277 3916171 SGTC_1952 st077036 64.1 µM 0.645032686374198 0.244536830316536 no 819 0.259453001938011 1282 2937007 SGTC_1679 SEC14.276 6.7 µM 0.644249538999192 0.244798965875491 no 820 0.259706815824087 1298 1005053 YMR079W SEC14 SGTC_1008 4106-0037 6 µM 0.642819272488113 0.245278095655118 no 821 0.260170688091437 1256 2905394 SGTC_982 1491-0518 27.5 µM 0.642724046470792 0.245310013628267 no 822 0.260201587497396 1251 3091256 SGTC_3010 9080089 71.4286 µM 0.642564399361193 0.245363529350819 no 823 0.260253394818946 1300 17027233 SGTC_719 2810-4230 27.3 µM 0.642483154851313 0.245390765943059 no 824 0.260279761636606 1254 721079 SGTC_151 3013-0144 2.285 µM 0.642157364642552 0.245500000905054 no 825 0.260385506310222 1275 906558 YHR107C CDC12 SGTC_1930 st074634 34.3 µM 0.642024000227922 0.245544724506793 no 826 0.260428799986724 1257 684253 YOR116C RPO31 SGTC_2849 9019321 12.99 µM 0.640925633703503 0.245913226847561 no 827 0.260785500254877 1266 16489627 SGTC_1625 st003711 30.1 µM 0.640547891783308 0.24604002794101 no 828 0.260908231979828 1351 24207034 YER133W GLC7 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.63989653261753 0.246258759730572 no 829 0.261119934148016 1322 5393153 SGTC_435 c-PAF 6.7 µM 0.638575405027669 0.246702725276177 no 830 0.261549592772803 1245 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1846 st056244 14.8 µM 0.637484502326696 0.247069646470622 no 831 0.261904650761655 1309 5393182 SGTC_2664 lyso-paf C-16 73.48 µM 0.636292581144117 0.247470878366128 no 832 0.262292869775 1291 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_981 1488-1094 54.9 µM 0.636223748929121 0.247494059722437 no 833 0.262315298020335 1258 3449522 SGTC_2985 9022375 71.43 µM 0.635745946322275 0.247655006358685 no 834 0.262471011988792 1318 4939335 SGTC_2805 7950783 58.44 µM 0.635409442735796 0.247768390305617 no 835 0.262580705560673 1296 1178958 YDL195W SEC31 SGTC_1779 st039427 55 µM 0.635398405008131 0.247772109906654 no 836 0.262584304040859 1355 1124498 SGTC_2272 7805186 180 µM 0.635016095142443 0.247900962809302 no 837 0.262708958899116 1272 2956062 YPR165W RHO1 SGTC_185 k048-0037 25.491 µM 0.634693587950655 0.248009687750643 no 838 0.26281413820464 1289 6827589 SGTC_1403 3909-7815 62.9 µM 0.632096352911457 0.248886204961429 no 839 0.26366195910908 1268 6615483 SGTC_2977 9011197 71.43 µM 0.63105499444727 0.249238106086959 no 840 0.264002283372544 1335 2704722 SGTC_2292 7671323 168.05 µM 0.630862629918129 0.249303139821817 no 841 0.264065174123911 1284 937504 SGTC_1056 3448-1962 115 µM 0.62925280265234 0.249847736468374 no 842 0.264591782526189 1300 715507 SGTC_2667 digitoxin 100 µM 0.629073503368473 0.249908431597155 no 843 0.264650468145814 1266 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_429 1112-0049 25.5 µM 0.628173989731538 0.250213046684957 no 844 0.264944983681039 1270 2836170 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.627459582125797 0.250455116908045 no 845 0.265179011073757 1328 1273210 SGTC_1370 2001-0092 44.6 µM 0.627019268034187 0.250604374947811 no 846 0.265323302511934 1414 790957 SGTC_3194 9111903 49.47 µM 0.625297632777903 0.251188428326781 no 847 0.265887866673357 1340 17087251 SGTC_1684 st024538 14.6195 µM 0.625197513824993 0.251222415155162 no 848 0.265920716721508 1293 6732859 SGTC_2204 7233102 200 µM 0.62485409547117 0.251339011962479 no 849 0.266033411403198 1254 2172480 SGTC_1855 st056195 39.6 µM 0.624503641926694 0.251458026831788 no 850 0.266148439656163 1292 4028379 SGTC_3124 9127567 49.47 µM 0.624034115147361 0.251617525927606 no 851 0.266302590400016 1283 17592030 SGTC_933 2914-0560 114 µM 0.623467460947624 0.251810090527835 no 852 0.266488689285811 1337 463887 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.622878009528931 0.252010484779026 no 853 0.266682344946002 1304 688669 SGTC_2723 salbutamol 83.58 µM 0.62170652616561 0.25240900056881 no 854 0.267067429778866 1307 9884233 β2-adrenoceptor agonist SGTC_1217 1183-1422 255 µM 0.621384576212781 0.252518579818128 no 855 0.267173308906223 1349 2849664 SGTC_1244 0416-0015 52.5 µM 0.621276943487638 0.252555219403783 no 856 0.267208710620626 1326 96201 SGTC_625 k213-0058 121 µM 0.619489753902133 0.253164011215787 no 857 0.267796884864013 1373 3655420 SGTC_3269 9137823 49.47 µM 0.61892037575049 0.253358127309867 no 858 0.267984407357893 1253 17682936 SGTC_1480 1070-0044 41.2 µM 0.618551219997517 0.253484024078314 no 859 0.268106022698669 1340 3124987 SGTC_2283 7944793 200 µM 0.616650730709817 0.254132686263819 no 860 0.268732562651117 1274 2970533 SGTC_2168 5727979 200 µM 0.61579846669208 0.254423857768239 no 861 0.269013769756811 1248 695210 SGTC_2928 9011484 9.79 µM 0.615638006640714 0.254478697648223 no 862 0.269066730556061 1307 2994751 SGTC_2442 5158906 48.48 µM 0.615470488108337 0.254535956488611 no 863 0.269122026631449 1377 1893835 SGTC_2052 5265182 7.135 µM 0.615222247879015 0.254620818899863 no 864 0.269203978559562 1359 1239884 SGTC_1181 1222-0449 220 µM 0.615116050217735 0.254657127732606 no 865 0.269239041579507 1375 658318 SGTC_3249 9135183 49.47 µM 0.614163255207761 0.25498300828027 no 866 0.269553725992377 1340 4902779 SGTC_2083 5306046 65.942 µM 0.614089293153202 0.255008314339934 no 867 0.269578161519716 1319 539837 SGTC_1728 st035614 33.7865 µM 0.612679439440648 0.255490945826664 no 868 0.270044160037199 1374 15945546 SGTC_3048 9093155 49.47 µM 0.612267046960061 0.255632209211828 no 869 0.270180544147364 1279 25236002 SGTC_2101 5377231 179.231 µM 0.612240063906882 0.255641453569734 no 870 0.270189469030803 1372 2844213 SGTC_3296 9122258 64.045 µM 0.611759011046837 0.255806290932062 no 871 0.270348606259578 1337 4730474 SGTC_3157 9099274 49.47 µM 0.61097705769219 0.256074353068177 no 872 0.270607384402632 1294 17217662 SGTC_2584 androsterone 48.74 µM 0.610741460462795 0.256155147080269 no 873 0.270685376744452 1348 2754130 A steroid. SGTC_2999 9069765 71.4286 µM 0.609138589780338 0.256705176632998 no 874 0.271216290431236 1345 2097066 SGTC_538 2922-0838 53.3 µM 0.607443411871796 0.257287550005192 no 875 0.271778343006393 1380 777039 SGTC_1343 1487-0095 224 µM 0.606521776658372 0.257604462992519 no 876 0.272084163102486 1331 4560101 YGL055W OLE1 SGTC_718 1130-0073 349 µM 0.605639640305211 0.257907983677227 no 877 0.272377036719046 1405 6740020 SGTC_1204 4049-0315 18.3 µM 0.605152126756718 0.258075804262218 no 878 0.272538960778166 1438 588402 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.604762381401331 0.25821001006267 no 879 0.272668446214505 1351 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1252 0493-0875 34.8 µM 0.603396244267497 0.258680714320679 no 880 0.273122560063449 1338 3960963 SGTC_1907 st060210 83.7 µM 0.600244854386852 0.259768221387616 no 881 0.274171532238182 1372 688793 SGTC_695 3505-6186 243 µM 0.599980888694336 0.259859419767185 no 882 0.274259486143826 1355 1819379 SGTC_986 1493-0483 84 µM 0.599450986139713 0.26004254740147 no 883 0.274436092801556 1298 40079 SGTC_3030 9087619 49.47 µM 0.599215668882966 0.260123891406077 no 884 0.274514537655388 1293 25236973 SGTC_3199 9111318 49.47 µM 0.595950620844362 0.261253898850029 no 885 0.275604107357438 1366 8548020 SGTC_2359 9039622 200 µM 0.595217507301892 0.261507969964975 no 886 0.275849044558281 1315 6463596 SGTC_1421 4029-0249 71.4 µM 0.592730449079848 0.262370840159048 no 887 0.276680780165633 1443 2894095 SGTC_2873 9040596 71.43 µM 0.59176770458795 0.26270524969022 no 888 0.277003076046619 1344 6463863 SGTC_2237 6667747 47.222 µM 0.590923675621057 0.262998602628502 no 889 0.27728578089077 1362 729940 YDL015C TSC13 SGTC_497 capsazepine 133 µM 0.589829596293941 0.263379112765704 no 890 0.277652449196247 1298 2733484 A calcium channel blocker. SGTC_1404 3909-7820 48.3 µM 0.589790316964324 0.263392778958979 no 891 0.277665617622198 1343 23741373 SGTC_425 3825-7017 13.1 µM 0.588601258479048 0.263806651377713 no 892 0.278064394746178 1438 3397440 SGTC_968 1309-0633 340 µM 0.588083793924626 0.263986867387052 no 893 0.278238025167405 1338 3761976 SGTC_1190 1486-1332 13 µM 0.586669060727897 0.264479892819112 no 894 0.278712995392108 1333 4150046 SGTC_1708 st033234 31.827 µM 0.58639874799673 0.264574148359609 no 895 0.278803792733616 1429 674664 SGTC_2768 sulfasalazine 50.2 µM 0.583795956260454 0.265482591300896 no 896 0.279678799586418 1461 5384001 An antioxidant and salicylic acid derivative. SGTC_234 nsc-17383 10.7 µM 0.58357140179039 0.265561040823615 no 897 0.27975435274177 1389 408974 SGTC_3096 9117468 49.47 µM 0.582868037021374 0.26580684182278 no 898 0.279991069535807 1277 41316311 SGTC_2693 st077581 40.7 µM 0.582693500687528 0.265867853923854 no 899 0.280049824620106 1370 25238761 SGTC_1664 st014217 9.02 µM 0.582623790191822 0.2658922243793 no 900 0.280073293301098 1401 3982782 SGTC_1714 st033236 13.627 µM 0.581565387279616 0.266262375977952 no 901 0.280429731455595 1441 2916566 SGTC_711 k292-0785 179 µM 0.580272239646015 0.266714977772879 no 902 0.280865522397837 1350 4146315 SGTC_3139 9095020 49.47 µM 0.580116824163042 0.266769399372173 no 903 0.280917919468412 1203 25236292 SGTC_2107 5363541 170.161 µM 0.578956967256584 0.267175721812991 no 904 0.281309104956982 1347 244052 SGTC_3302 9125395 16.351 µM 0.578284827745084 0.267411329403899 no 905 0.281535918051948 1394 17599668 SGTC_1611 st001856 99.4 µM 0.573527103250013 0.269082063201731 no 906 0.283143926625557 1327 647478 SGTC_407 eburnamonine 100 µM 0.572323240044343 0.269505643561846 no 907 0.283551504005033 1329 3195 SGTC_84 0443-0269 128.823 µM 0.569978697793107 0.270331530876863 no 908 0.284346073186464 1332 6150058 SGTC_1427 4048-4900 550 nM 0.568144790173339 0.270978422969519 no 909 0.284968328212527 1441 24132586 SGTC_393 acivicin 6.25 µM 0.565275022738149 0.271992251357077 no 910 0.285943357439812 1364 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_3245 9134821 49.47 µM 0.56521769013335 0.272012524962723 no 911 0.28596285285318 1326 17014901 SGTC_2586 curcumin 80 µM 0.563578162073264 0.272592602687173 no 912 0.286520626144653 1443 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2140 5586273 200 µM 0.563457342735418 0.272635373785267 no 913 0.28656174972516 1387 854421 SGTC_645 0845-0943 5.41 µM 0.561717864192572 0.273251533288218 no 914 0.28715413050311 1378 1885106 SGTC_2386 9075165 157.42 µM 0.56012164350736 0.273817554164565 no 915 0.287698234256219 1368 16452277 SGTC_2265 7929201 200 µM 0.559602394689094 0.274001805024989 no 916 0.287875335559854 1360 1265108 SGTC_351 caspofungin 25 nM 0.559143136328777 0.274164819847826 no 917 0.288032018683266 1478 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2064 5220758 200 µM 0.558622761365221 0.274349586024963 no 918 0.288209601312829 1421 788518 SGTC_2245 6637752 200 µM 0.558494699751924 0.274395065458213 no 919 0.288253311406006 1444 681890 SGTC_3263 9137018 49.47 µM 0.558291070428421 0.274467389453064 no 920 0.288322820768658 1328 43844957 SGTC_180 1486-1293 102.781 µM 0.558180029287534 0.274506832426155 no 921 0.288360728260752 1510 4140536 SGTC_640 3381-0960 37.1 µM 0.557563517924644 0.274725874559794 no 922 0.288571237122693 1486 1745025 SGTC_2514 salinomycin 42.74 µM 0.555042644096019 0.275622418872165 no 923 0.289432746208815 1489 23682228 A polyether potassium ionophore. SGTC_857 0438-0306 1.35 µM 0.554990640892705 0.275640928852676 no 924 0.289450531024625 1423 4686136 SGTC_615 k087-0205 167 µM 0.554012862709305 0.275989072204433 no 925 0.289785021425026 1357 9642773 SGTC_3261 9137475 49.47 µM 0.552811468735455 0.276417130659306 no 926 0.290196257202961 1353 17027690 SGTC_1153 4055-0057 267 µM 0.552705331248519 0.276454963251298 no 927 0.29023260108353 1367 882706 SGTC_529 4076-0302 30.3 µM 0.552219466182819 0.276628181736153 no 928 0.290398999506621 1391 5816522 SGTC_2528 xanthyletin 44.79 µM 0.548886128724446 0.277818000870882 no 929 0.291541799053192 1445 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2394 5221648 200 µM 0.548725204738994 0.277875505095334 no 930 0.291597023169614 1553 788586 SGTC_1127 asiatic acid 681.4 nM 0.548651627239913 0.277901799053118 no 931 0.291622274307959 1383 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_3188 9110789 49.47 µM 0.547297558868294 0.278385911206521 no 932 0.292087160340504 1458 849217 SGTC_2160 5660466 132.927 µM 0.546739440488059 0.278585571555328 no 933 0.2922788768809 1393 2859134 SGTC_2566 crystal violet carbinol 226 nM 0.545199181931022 0.279136942653216 no 934 0.292808267054651 1334 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2823 7987624 58.44 µM 0.545151970715798 0.279153851373776 no 935 0.292824500680119 1438 2239440 SGTC_1213 1315-0166 115 µM 0.541586124137175 0.280432398119234 no 936 0.294051826445196 1370 768401 SGTC_3116 9124943 49.47 µM 0.540380698667094 0.280865247883607 no 937 0.294467257957651 1331 41905195 YPL160W CDC60 SGTC_1983 st071813 46.9 µM 0.538404905460633 0.281575422656836 no 938 0.295148770240503 1415 11838595 SGTC_414 piperonyl butoxide 100 µM 0.538354179054042 0.281593667042438 no 939 0.295166276908137 1387 5794 A potent inhibitor of cytochrome P450. SGTC_2463 5473429 200 µM 0.537013975347374 0.282075894436392 no 940 0.295628980302301 1438 5399405 SGTC_2495 cafestol 54.53 µM 0.535379153356855 0.282664668175188 no 941 0.296193851204155 1455 16667697 An anti-infammatory. SGTC_1830 st055982 50.3 µM 0.535046042202715 0.282784709041185 no 942 0.296309009933468 1442 455313 An antimicrobial agent. SGTC_1278 0874-0585 172 µM 0.53443444716073 0.28300516887535 no 943 0.296520495818415 1435 766306 SGTC_1263 0774-1208 64.8 µM 0.533910464381224 0.283194112978407 no 944 0.296701740902777 1532 906585 SGTC_850 0388-0143 75.9 µM 0.531717575877332 0.283985507381927 no 945 0.297460808503239 1423 67273 SGTC_2152 5568786 200 µM 0.531065506186738 0.284221037614862 no 946 0.297686693140143 1417 5399883 SGTC_2551 apiole 73.87 µM 0.530711900824373 0.284348800357757 no 947 0.297809218931683 1388 10659 A possible DNA adduct former. SGTC_848 0368-0089 85.6 µM 0.530026297863597 0.284596596814301 no 948 0.298046848837961 1408 762535 SGTC_119 0121-0043 24.815 µM 0.529393642698971 0.284825347864625 no 949 0.298266203666119 1463 1092378 SGTC_2866 9034245 58.44 µM 0.529331157507093 0.284847945584705 no 950 0.298287872582093 1484 6462273 SGTC_2871 9038510 12.99 µM 0.529301953865965 0.284858507351661 no 951 0.298298000207273 1552 4945164 SGTC_2618 avocadyne 43.43 µM 0.529287938759086 0.284863576111054 no 952 0.298302860607119 1439 3015189 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.528946367945173 0.284987123274072 no 953 0.298421327555044 1443 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2435 5706476 10.6 µM 0.527754410271935 0.285418457906067 no 954 0.298834901652939 1483 5725375 SGTC_2845 9003024 42.97 µM 0.527695638270291 0.285439733814693 no 955 0.298855300536971 1518 2990173 SGTC_280 3448-3607 3.04 µM 0.527618460547666 0.285467673880271 no 956 0.298882088732739 1439 626179 SGTC_1300 1094-0077 113 µM 0.527401670231685 0.285546163799278 no 957 0.298957341948074 1408 5532636 SGTC_2622 2-methoxyxanthone 59.94 µM 0.526216216204675 0.285975544378104 no 958 0.299368994107087 1561 71034 A hepatoprotective. SGTC_8 0354-0001 70 µM 0.524766350920549 0.286501113569526 no 959 0.299872812958892 1479 4993152 SGTC_383 2324-0395 7.37 µM 0.524084930749611 0.286748283310707 no 960 0.300109734594112 1508 3146421 SGTC_3234 9132280 49.47 µM 0.520429015009277 0.288076107059134 no 961 0.301382295708481 1428 17612295 SGTC_150 3970-0969 77.2 µM 0.519367865518238 0.288462057792039 no 962 0.301752117876644 1493 6615640 SGTC_2004 4023728 41.89 µM 0.516853388966185 0.289377569794967 no 963 0.30262925373547 1477 360084 YDR527W RBA50 SGTC_120 rhodamine 6G 52.259 µM 0.515957643716248 0.289704036929002 no 964 0.302941996235052 1433 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_3218 9131285 49.47 µM 0.515547254810827 0.289853666734634 no 965 0.303085328637736 1591 17156417 SGTC_320 4092-0846 5.34 µM 0.515212568118404 0.289975721972884 no 966 0.303202243744066 1498 1359356 SGTC_1976 st070609 63.5 µM 0.513368771734689 0.290648558649906 no 967 0.303846692876131 1428 682556 SGTC_2774 tamoxifen 10.92 µM 0.512435830792443 0.290989284717599 no 968 0.304173009762992 1480 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2757 clomiphene 4.22 µM 0.512361327052824 0.291016502808924 no 969 0.304199075837333 1588 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2161 5662504 8.5105 µM 0.510576618085258 0.291668857120552 no 970 0.304823775972823 1442 2859334 SGTC_3186 9110464 49.47 µM 0.509858547025836 0.291931521629653 no 971 0.305075282512737 1505 17018021 SGTC_1183 1254-0324 198 µM 0.509405756218365 0.292097205407313 no 972 0.305233921201811 1530 5799357 SGTC_2983 9022671 12.99 µM 0.509382807833161 0.292105603772868 no 973 0.305241962316946 1588 6405161 SGTC_252 miconazole 1.30953 nM 0.509074993482468 0.292218264715389 no 974 0.305349829563341 1450 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2058 5236698 133 µM 0.508929115994827 0.292271663357019 no 975 0.305400955250957 1482 766665 SGTC_534 k292-0788 63.4 µM 0.504852186945017 0.293765860985341 no 976 0.306831329191609 1530 4146317 SGTC_2555 cholic acid 100 µM 0.504219288096138 0.293998135480611 no 977 0.307053643884155 1476 6708657 Influences liver metabolism. SGTC_761 k216-0224 480 µM 0.504088378417171 0.294046190056325 no 978 0.307099636623069 1625 1340404 SGTC_2223 6903751 107.57 µM 0.502955362548196 0.294462251310064 no 979 0.307497827928585 1480 5598863 SGTC_2182 6325192 200 µM 0.502788894261801 0.294523403972018 no 980 0.307556351294764 1443 736248 SGTC_2339 9000433 200 µM 0.502543626610506 0.294613514511919 no 981 0.30764258618447 1434 2988954 SGTC_2954 9074818 52.69 µM 0.502368456344607 0.294677879284301 no 982 0.30770418168829 1524 16648742 SGTC_663 1486-0733 13.9 µM 0.501714649874524 0.294918171976689 no 983 0.307934128949446 1470 722445 YPR165W RHO1 SGTC_3324 9138759 60.749 µM 0.49801550481315 0.296279411784246 no 984 0.309236556955933 1495 45595710 SGTC_2402 5553605 200 µM 0.496873082125435 0.296700390860427 no 985 0.309639277331677 1568 6758546 SGTC_2595 hexamethylquercetagetin 100 µM 0.496301523739743 0.296911111028753 no 986 0.309840845700263 1494 386331 SGTC_1078 idebenone 36.1 µM 0.493481983788175 0.297951609909291 no 987 0.310836033343544 1496 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_376 3970-0862 59.1 µM 0.49347470855367 0.297954296848353 no 988 0.310838603012487 1574 3135186 SGTC_449 xestospongin c 11.1929 µM 0.493466011528244 0.297957508907397 no 989 0.310841674881056 1544 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1916 st067606 49.2 µM 0.49234151300632 0.298372951108378 no 990 0.311238968985814 1594 19590279 SGTC_2027 5150920 200 µM 0.491538684803294 0.29866971450255 no 991 0.311522749091674 1542 786715 SGTC_2478 5763493 32.33 µM 0.491278243214386 0.298766014891775 no 992 0.311614832882704 1532 1365576 YLR208W SEC13 SGTC_2345 9052315 157.45 µM 0.490891569853669 0.29890901652648 no 993 0.311751569910603 1517 6469265 SGTC_2699 st077704 54.6 µM 0.49023167191035 0.299153135338217 no 994 0.311984985682663 1521 645852 SGTC_2419 paclitaxel 166.5 µM 0.489860215753597 0.299290589462858 no 995 0.312116408506621 1463 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2648 atorvastatin 78.68 µM 0.486528190877204 0.300524855331999 no 996 0.313296361397332 1575 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_3119 9125183 49.47 µM 0.48640776608737 0.300569506716033 no 997 0.313339042716171 1451 22695334 SGTC_2888 9058547 12.99 µM 0.485401914605839 0.300942575610948 no 998 0.313695637252857 1436 16476514 SGTC_394 menadione 8.33 µM 0.4852877574428 0.300984929531539 no 999 0.313736119267135 1502 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1363 1636-0063 10.4 µM 0.484852493559759 0.301146443234047 no 1000 0.31389049159877 1516 6072185 SGTC_1063 disulfiram 1.84 µM 0.484260326611922 0.301366241757739 no 1001 0.314100564075812 1495 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3160 9100216 49.47 µM 0.48415560547591 0.30140511930894 no 1002 0.314137720391392 1500 17191039 SGTC_2926 9010726 65.15 µM 0.483451186060188 0.301666692516795 no 1003 0.314387705794306 1454 2994293 SGTC_3017 9080681 49.47 µM 0.483363506371373 0.301699257901213 no 1004 0.314418827652542 1482 16451914 SGTC_1222 0366-0074 1.18 µM 0.482968548229081 0.301845970119921 no 1005 0.314559034182179 1609 286520 SGTC_2646 retinol 96.75 µM 0.481224229983903 0.30249430241979 no 1006 0.315178570902317 1518 445354 A vitamin A analog and teratogen. SGTC_1331 1472-0049 76.2 µM 0.480726467018702 0.302679426561028 no 1007 0.315355458909785 1468 24051409 SGTC_2776 terbinafine 19.92 µM 0.480313109229751 0.302833197949635 no 1008 0.315502384366786 1493 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_888 0916-0002 6.97 µM 0.479458434984699 0.30315125238388 no 1009 0.315806265514238 1553 2802138 YIL048W NEO1 SGTC_1281 0884-0031 11.8 µM 0.479457350976704 0.303151655876338 no 1010 0.315806651014583 1481 1548255 SGTC_2407 paclitaxel 400 µM 0.47858860305962 0.303475100826465 no 1011 0.316115663887385 1651 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3142 9086498 49.47 µM 0.47855750862308 0.303486680503693 no 1012 0.316126726534355 1474 25236367 SGTC_1572 epiandrosterone 68.9 µM 0.478481317782007 0.303515055074369 no 1013 0.31615383408503 1528 441302 A steroid. SGTC_601 0986-0029 62.9 µM 0.475952378329933 0.304457540159056 no 1014 0.317054152599698 1520 24747981 SGTC_2934 9036370 36.88 µM 0.475393838445495 0.304665872263598 no 1015 0.317253142691426 1622 6462800 SGTC_1177 0983-0204 23.6 µM 0.470419052038794 0.306524227909147 no 1016 0.319027827526771 1604 766818 SGTC_1145 3546-0597 10.2 µM 0.470171428208049 0.30661685964887 no 1017 0.319116272752448 1517 875334 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.469993179237375 0.30668354711598 no 1018 0.319179945335608 1551 2724278 An inhibitor of dopamine biosynthesis. SGTC_255 tunicamycin 200.472 nM 0.468672032903963 0.307178020905532 no 1019 0.319652040193565 1564 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3340 9146634 11.102 µM 0.468109817710058 0.307388551204925 no 1020 0.31985302938064 1524 4907387 SGTC_768 0384-0033 77.3 µM 0.466890903633272 0.307845210639441 no 1021 0.320288966828638 1491 3965305 YMR134W ERG29 SGTC_1792 st045773 43.6 µM 0.46559302444959 0.308331781283382 no 1022 0.320753418468902 1517 2919270 SGTC_3032 9089427 49.47 µM 0.465168941011986 0.308490841843682 no 1023 0.320905239432274 1497 17173707 SGTC_817 1391-0715 46 µM 0.463312666220748 0.309187495775758 no 1024 0.321570134044542 1516 1353946 SGTC_3133 9127736 49.47 µM 0.46078807731916 0.310136067585076 no 1025 0.322475328240728 1621 27243420 SGTC_2791 5663188 71.43 µM 0.459750001796898 0.310526474341131 no 1026 0.322847837336454 1614 54690634 SGTC_613 3914-0030 117 µM 0.459395707247962 0.31065976882634 no 1027 0.322975015184437 1476 1145395 SGTC_1945 st075991 56.6 µM 0.459340226222897 0.310680644429519 no 1028 0.322994932571537 1489 1084980 SGTC_226 1,3-diallylurea 8.28947 mM 0.459149000069715 0.310752600930466 no 1029 0.323063585612917 1551 74537 YKL182W FAS1 SGTC_1811 st050069 61.5 µM 0.458644799084714 0.310942361451051 no 1030 0.323244630183009 1547 3877702 SGTC_390 dec-rvkr-cmk 16.7 µM 0.458595599857472 0.310960880710803 no 1031 0.323262298501852 1568 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_3238 9133470 49.47 µM 0.458087138282907 0.311152300612224 no 1032 0.323444919452974 1617 3534688 SGTC_100 0086-0128 49.5915 µM 0.457495610375401 0.31137505668439 no 1033 0.323657428348179 1441 93297 SGTC_2967 9089538 49.85 µM 0.45731785804447 0.311442007705761 no 1034 0.32372129786405 1715 728216 SGTC_3073 9114972 49.47 µM 0.457186937127249 0.311491323503715 no 1035 0.323768343355852 1637 41905075 SGTC_1657 st012939 43.4 µM 0.45687272198617 0.311609697078294 no 1036 0.323881265799644 1621 24207257 SGTC_1616 st002734 56.1 µM 0.456188009374957 0.311867714780991 no 1037 0.324127393539408 1564 4026101 SGTC_276 colchicine 750 µM 0.456038759286768 0.311923968399946 no 1038 0.324181053392086 1577 2833 A microtubule depolymerizer. SGTC_698 k064-0052 127 µM 0.455849393658977 0.311995348219169 no 1039 0.324249141233021 1614 5088751 SGTC_2995 9067767 71.4286 µM 0.454581380998474 0.312473497005967 no 1040 0.324705216114054 1568 11673567 SGTC_2116 5511452 16.8835 µM 0.451242218362148 0.313734155387324 no 1041 0.325907492341497 1570 870744 SGTC_3084 9116877 49.47 µM 0.451114885569035 0.313782271463919 no 1042 0.325953374874532 1579 27241325 SGTC_1871 st057448 67.3 µM 0.450435100451304 0.314039199893502 no 1043 0.326198370204543 1643 691747 SGTC_3058 9093861 49.47 µM 0.449330803699911 0.314456766939943 no 1044 0.326596519909733 1577 17217477 SGTC_1745 st081495 74 µM 0.448709787156355 0.314691695908699 no 1045 0.326820511736351 1587 13842402 YBL026W LSM2 SGTC_2833 9001315 45.46 µM 0.447455458648625 0.31516643392093 no 1046 0.327273120479536 1580 2989378 SGTC_275 trichlorophene 5.69 µM 0.446909503471361 0.315373162379812 no 1047 0.327470200974789 1588 62616 SGTC_716 1683-5115 658 µM 0.444050951348076 0.316456508980378 no 1048 0.328502873496798 1580 723597 SGTC_2497 7-hydroxyflavone 100 µM 0.444027918138498 0.316465244622896 no 1049 0.328511199745561 1620 5281894 SGTC_2425 5628681 7.85 µM 0.443376225240485 0.316712449999095 no 1050 0.328746814747219 1649 5714958 SGTC_1796 st049173 110.4 µM 0.4411041714594 0.317574943414528 no 1051 0.32956879185731 1598 94134 SGTC_938 3126-1755 342 µM 0.439452518173549 0.318202549324395 no 1052 0.330166839799348 1603 1777771 SGTC_1951 sophoraflavanone G 9.2 µM 0.43924207405859 0.318282552791192 no 1053 0.330243070827449 1537 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_844 0330-0132 15.3 µM 0.438864372351432 0.318426162982893 no 1054 0.330379906720268 1623 2828079 SGTC_3283 9109332 35.8195 µM 0.437178769248698 0.319067397378751 no 1055 0.330990852751144 1522 17027281 SGTC_969 1313-0238 134 µM 0.437132145203898 0.319085141731155 no 1056 0.331007758021196 1584 5212874 SGTC_2680 butyl paraben 22.24 µM 0.436426416831113 0.31935378106836 no 1057 0.331263687978357 1592 7184 An antifungal and steroid mimetic. SGTC_2118 5526350 200 µM 0.435593082400156 0.319671116476434 no 1058 0.331565995333415 1616 743594 SGTC_270 tamoxifen 5.46 µM 0.435220497770526 0.319813040181372 no 1059 0.331701192760276 1701 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_656 4090-1979 187 µM 0.434719399492404 0.320003958481058 no 1060 0.331883057691599 1685 22330961 SGTC_2287 7945887 168.79 µM 0.434417076895407 0.32011916636752 no 1061 0.331992799601583 1650 1245853 SGTC_2336 9001819 198.65 µM 0.433676437143871 0.320401479685027 no 1062 0.332261709801999 1672 2989602 SGTC_443 clozapine 122 µM 0.433179552400717 0.320590937982439 no 1063 0.332442166281732 1637 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2193 5925765 200 µM 0.432368596473936 0.320900249588647 no 1064 0.33273676921275 1624 877370 SGTC_3018 9082602 49.47 µM 0.432307403642578 0.320923594564808 no 1065 0.332759003452716 1584 17332089 SGTC_1882 5615643 20 µM 0.431986812660279 0.321045911127364 no 1066 0.332875498879128 1542 2253075 SGTC_1374 2889-5571 141 µM 0.43191510363816 0.321073273261059 no 1067 0.332901558505196 1560 2853281 SGTC_1305 1181-0477 144 µM 0.431606552047098 0.321191018899685 no 1068 0.333013697801853 1666 6252086 SGTC_74 000s-0487 160.283 µM 0.430993670529033 0.321424952468171 no 1069 0.333236486369866 1479 677548 SGTC_232 clozapine 119 µM 0.430930353839472 0.321449124146244 no 1070 0.333259505975949 1595 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1856 st057054 55.7 µM 0.430739726869487 0.321521902157902 no 1071 0.33332881468231 1692 1266018 SGTC_919 tnp00227 403.569 nM 0.430407476600078 0.321648765820671 no 1072 0.333449628801364 1603 1269246 A methoxyflavone. YNL221C POP1 SGTC_927 2425-1185 123 µM 0.428071767774747 0.322541199721849 no 1073 0.334299435273927 1523 730375 SGTC_2067 5224629 34.075 µM 0.427989593959932 0.322572615578926 no 1074 0.334329348269826 1552 2835000 SGTC_1636 st007707 68.9 µM 0.427532128659981 0.322747532210366 no 1075 0.334495894481279 1687 403051 SGTC_1849 st056239 19.2 µM 0.426723901687325 0.323056662082186 no 1076 0.33479021965809 1480 5393181 SGTC_1790 st045711 43.5 µM 0.425794217246443 0.323412398082308 no 1077 0.33512890052286 1711 585119 SGTC_1187 1391-0724 117 µM 0.42465426005129 0.323848813586889 no 1078 0.335544366027051 1613 6997986 SGTC_1569 carminic acid 40.6 µM 0.424565576369729 0.323882774968269 no 1079 0.335576695864835 1668 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.423009759092937 0.324478812864581 no 1080 0.336144070408716 1624 7104 SGTC_2084 5306078 60.6385 µM 0.420746767031021 0.32534657425 no 1081 0.336970003523024 1635 679340 SGTC_1402 3909-7673 35.9 µM 0.419791662082303 0.325713101159415 no 1082 0.337318828241786 1567 5328014 SGTC_1279 0874-0590 65.2 µM 0.418823383443392 0.326084855607464 no 1083 0.33767260706732 1622 3523074 SGTC_3289 9119912 71.43 µM 0.418623607991225 0.326161577593221 no 1084 0.337745616655622 1606 17014829 SGTC_3284 9108171 64.8615 µM 0.417309351461883 0.326666489430971 no 1085 0.338226074660653 1608 8687505 SGTC_3026 9090633 49.47 µM 0.417301334057285 0.326669570537794 no 1086 0.338229006424817 1574 25236842 SGTC_2828 7998861 71.43 µM 0.415546879590704 0.327344095410427 no 1087 0.338870802160749 1729 2988188 SGTC_1163 k060-0048 49.9 µM 0.414799171474764 0.327631733963716 no 1088 0.339144463077371 1599 6809982 SGTC_2259 7964009 200 µM 0.413976141311122 0.327948466736621 no 1089 0.339445789979613 1651 313134 SGTC_1436 4092-1007 8.32 µM 0.413444313071484 0.328153199976538 no 1090 0.339640556977282 1595 2881121 SGTC_1249 0481-0015 10.2 µM 0.412942631364033 0.328346375301147 no 1091 0.339824322921403 1562 4227577 SGTC_2200 6600604 21.907 µM 0.412556804953944 0.328494971130165 no 1092 0.339965676987551 1579 2904777 SGTC_1840 st055363 71 µM 0.412301595124967 0.328593276657124 no 1093 0.340059189813943 1543 676033 SGTC_562 3772-2733 112 µM 0.412209916593336 0.328628593657714 no 1094 0.340092784647736 1665 2876874 YIL048W NEO1 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.41164508800575 0.328846214360168 no 1095 0.34029978937344 1581 6708630 An antioxidant. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.411422428049165 0.328932018139143 no 1096 0.34038140552657 1710 688664 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.411178546250459 0.329026010268813 no 1097 0.340470809139616 1597 689007 SGTC_302 1094-0063 18.9 µM 0.409904672786792 0.32951713714408 no 1098 0.340937938729289 1590 5440289 SGTC_175 3793-3120 23.7 µM 0.408972228659571 0.329876816522256 no 1099 0.34128002082244 1589 5322297 SGTC_2032 5185112 25.99 µM 0.407772259696852 0.330339921987655 no 1100 0.341720440657661 1621 5718189 SGTC_1223 0764-0573 147 µM 0.404450527000805 0.331623236444981 no 1101 0.342940725604134 1603 1609797 SGTC_1759 st043059 70 µM 0.404169467010988 0.331731911850481 no 1102 0.343044052355533 1564 669426 SGTC_1624 st003710 6.25 µM 0.403810642683851 0.331870676403862 no 1103 0.343175984853055 1720 24207033 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.403635948841207 0.331938242361455 no 1104 0.343240223190386 1646 4213774 SGTC_157 1348-1695 65.819 µM 0.403384611388083 0.332035461189796 no 1105 0.343332652826322 1607 5380510 SGTC_1958 st076513 41.9 µM 0.402631701597367 0.33232675884699 no 1106 0.343609592329066 1579 732122 YGL099W LSG1 SGTC_2191 5911152 200 µM 0.402050387960232 0.332551735991689 no 1107 0.343823471820227 1625 2875902 SGTC_3166 9102297 49.47 µM 0.401966071869272 0.332584372602088 no 1108 0.34385449792322 1580 25237072 SGTC_772 k072-0172 35.3 µM 0.401910039315142 0.33260606207795 no 1109 0.343875117010463 1523 5861980 SGTC_3219 9131112 49.47 µM 0.401252940719347 0.332860458233809 no 1110 0.344116953463084 1621 17612988 YMR079W SEC14 SGTC_902 1120-0002 2.07 µM 0.401212261403873 0.332876209788526 no 1111 0.344131927044518 1568 3280475 SGTC_2303 7774051 200 µM 0.399382544934185 0.333585004181826 no 1112 0.344805676721909 1700 2953184 SGTC_2439 5492030 7.2 µM 0.397310918034813 0.33438822716798 no 1113 0.345569098583016 1719 5722370 SGTC_1717 st033143 58.0435 µM 0.396314605875615 0.334774793449551 no 1114 0.345936476795545 1760 674616 SGTC_2437 5741531 144.16 µM 0.396198965482608 0.334819672945798 no 1115 0.345979127213005 1753 2262990 SGTC_324 1315-0088 19.6 µM 0.393812618951997 0.335746328776744 no 1116 0.3468596935856 1672 6787421 SGTC_2851 9015922 71.43 µM 0.393666485147774 0.335803107365459 no 1117 0.346913644180467 1722 2996893 SGTC_1515 3460-0031 42.1 µM 0.39326796361919 0.335957967312279 no 1118 0.347060788629928 1622 2876596 SGTC_1114 scopoletin 1.73284 µM 0.392988798615246 0.336066463557193 no 1119 0.347163877302953 1752 5280460 A coumarin with genotoxic properties. SGTC_467 ro 31-8220 72.8 µM 0.390293897814294 0.337114526063401 no 1120 0.348159617534536 1727 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_34 0469-0683 81.75 µM 0.39008461555083 0.337195970205179 no 1121 0.3482369892686 1705 3690923 SGTC_3105 9121040 49.47 µM 0.390038113825045 0.33721406782105 no 1122 0.348254181832487 1618 41448907 SGTC_1206 3978-0017 132 µM 0.389524829236642 0.337413853755072 no 1123 0.348443973522866 1722 3873677 SGTC_1948 st076329 66.6 µM 0.388658434122213 0.337751184997277 no 1124 0.348764417142808 1591 24208413 SGTC_289 k017-0060 526 µM 0.386919607798972 0.338428590828235 no 1125 0.34940786232414 1638 5512909 SGTC_2932 9016711 44.54 µM 0.385796163461662 0.338866536687487 no 1126 0.349823818438577 1799 7117328 SGTC_1034 k072-0165 12.7 µM 0.385094138421712 0.33914031374307 no 1127 0.350083835315449 1783 5835461 SGTC_795 0685-0265 78 µM 0.383598855601388 0.339723730023898 no 1128 0.350637894170645 1641 302754 SGTC_2576 guaiol 23.12 µM 0.382760596660899 0.340050962669061 no 1129 0.350948639947927 1819 227829 SGTC_301 4119-0100 24.5 µM 0.382693774846294 0.340077053210732 no 1130 0.350973415342602 1658 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2751 anetholtrithion 17.25 µM 0.382001669668296 0.340347330330711 no 1131 0.351230063085577 1759 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1923 st058458 19.1 µM 0.381629263192282 0.340492794420282 no 1132 0.351368187643519 1771 3534982 SGTC_2742 clothiapine 36.27 µM 0.380911764954042 0.34077312020941 no 1133 0.351634361139908 1745 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2188 6126565 140.678 µM 0.377861275009769 0.341965923633184 no 1134 0.352766825699908 1708 874518 SGTC_3328 9140624 29.0385 µM 0.37518015880946 0.343015598908789 no 1135 0.353763242619592 1781 4904392 SGTC_98 0074-0023 107.663 µM 0.370947043328809 0.344675358979143 no 1136 0.355338487659486 1612 3563821 SGTC_1573 oleylamine 1.06 µM 0.37073468540494 0.34475870142417 no 1137 0.355417576609059 1630 5356789 An amine of the fatty acid oleic acid. SGTC_2046 4110841 106 µM 0.370373557914719 0.344900447590207 no 1138 0.355552086446617 1748 44119630 YMR134W ERG29 SGTC_128 0906-2981 13.371 µM 0.369245912808097 0.345343199666623 no 1139 0.355972218284456 1751 6740226 SGTC_3094 9117742 49.47 µM 0.36891748555321 0.345472191290553 no 1140 0.356094614833999 1607 17149698 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.368671411403845 0.345568850038273 no 1141 0.356186330178842 1784 23847180 SGTC_478 N-arachidonylglycine 10 µM 0.366399025884275 0.346461925796204 no 1142 0.357033673254451 1736 5283389 SGTC_44 0929-0055 61.211 µM 0.365271560626802 0.346905351028738 no 1143 0.357454352622381 1621 1379590 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.365223417244559 0.346924290202088 no 1144 0.357472319722081 1732 1241132 A phosphatase inhibitor. SGTC_1434 4073-0095 163 µM 0.364354334774341 0.347266245149707 no 1145 0.357796715400595 1723 24133745 SGTC_2128 5255449 168.493 µM 0.364168915630599 0.34733921750206 no 1146 0.35786593867241 1647 736008 SGTC_2935 9038016 29.96 µM 0.362408840583561 0.348032182671802 no 1147 0.358523267030581 1774 6463195 SGTC_2146 5545642 200 µM 0.362349612170187 0.348055510537223 no 1148 0.358545394139334 1675 825326 SGTC_2918 7977171 22.06 µM 0.361589312893067 0.348355015136138 no 1149 0.35882947605767 1669 2236483 SGTC_211 3455-0679 143.504 µM 0.361243925286753 0.348491104886529 no 1150 0.358958554172077 1698 748649 SGTC_1321 1326-2144 215 µM 0.359022609764058 0.349366813844804 no 1151 0.359789087601019 1778 3513030 SGTC_2601 securinine 100 µM 0.358733160992285 0.349480982391936 no 1152 0.359897359226741 1641 442872 A GABA receptor antagonist. SGTC_1169 aniline yellow 25.8 µM 0.358596837090042 0.34953475794371 no 1153 0.359948356637583 1752 6051 A DNA damaging agent. SGTC_2689 tacrolimus 100 µM 0.358239303023961 0.349675808388012 no 1154 0.360082118403719 1666 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1024 4507-0395 26 µM 0.356895906970875 0.350205975710037 no 1155 0.360584866961489 1707 4201836 SGTC_2841 9004761 38.96 µM 0.356725842999001 0.350273111805962 no 1156 0.360648528407545 1571 2991039 SGTC_369 0957-0393 4.5 µM 0.356327017472796 0.350430574371558 no 1157 0.360797839195204 1625 6997992 SGTC_1322 1348-1070 12 µM 0.355400102881218 0.350796634037313 no 1158 0.361144935898823 1746 6758089 SGTC_803 4488-1585 147 µM 0.355225043922856 0.350865784368269 no 1159 0.361210502128728 1770 747204 SGTC_1079 idarubicin 2.36 µM 0.354918338602478 0.350986948456511 no 1160 0.361325384750693 1757 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2943 9068529 45.32 µM 0.354782631267065 0.35104056454269 no 1161 0.361376220643391 1690 3270634 SGTC_1235 benzylparaben 21.5 µM 0.353316523879792 0.351619992127152 no 1162 0.361925579546932 1710 7180 SGTC_3021 9087658 49.47 µM 0.352831950800955 0.351811578562891 no 1163 0.362107214515017 1751 25237042 SGTC_2424 5537928 59.2 µM 0.352487075419456 0.351947955423731 no 1164 0.362236504811328 1645 5382802 SGTC_668 1682-0499 62.6 µM 0.352448322710063 0.351963280911726 no 1165 0.362251033793143 1685 682214 SGTC_2929 9013348 24.6 µM 0.35163661555721 0.352284341015563 no 1166 0.362555400765293 1701 2995952 SGTC_2261 9010538 184.68 µM 0.350680939423286 0.352662481120095 no 1167 0.362913863344686 1637 6457250 SGTC_168 3970-0862 530.542 µM 0.348379908288791 0.353573545542459 no 1168 0.363777444722812 1722 3135186 SGTC_293 4049-0273 38.5 µM 0.347658390539856 0.353859394576036 no 1169 0.364048374526816 1709 1380311 SGTC_2739 tacrine 100.86 µM 0.347179715469828 0.35404908030438 no 1170 0.364228154453936 1706 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2246 7293507 91.5585 µM 0.346946919227421 0.354141344130766 no 1171 0.364315598452019 1860 887656 SGTC_2269 7935389 174.42 µM 0.346812017128583 0.35419481362029 no 1172 0.36436627423306 1637 97605 SGTC_869 0564-0080 44.1 µM 0.346589436254765 0.354283041554017 no 1173 0.364449891603713 1666 6843321 SGTC_2636 apigenin dimethyl ether 100 µM 0.346079768774032 0.354485096041945 no 1174 0.364641383624976 1738 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_959 1222-0044 107 µM 0.342578761830678 0.355874152682228 no 1175 0.365957690930375 1866 6083612 SGTC_2553 4-methylesculetin 85.09 µM 0.342361957730704 0.355960234870813 no 1176 0.366039256943722 1659 5319502 SGTC_3127 9126946 49.47 µM 0.341094099625579 0.356463785554394 no 1177 0.366516371493865 1645 27243249 SGTC_826 1683-5028 118 µM 0.340647241064104 0.356641322484924 no 1178 0.366684580481403 1722 722377 SGTC_643 k048-0106 28.4 µM 0.337240247360171 0.357995940048036 no 1179 0.367967899748074 1791 6763920 SGTC_939 1165-0479 45.3 µM 0.337083895732264 0.358058148394842 no 1180 0.368026828541882 1823 1377347 SGTC_587 k089-0003 57 µM 0.335628296652476 0.358637475021914 no 1181 0.368575591462869 1818 9659696 SGTC_1205 4161-2785 76 µM 0.335352708476888 0.358747195452355 no 1182 0.368679518819307 1637 3498106 SGTC_3062 9077494 49.47 µM 0.335036892770027 0.358872946078326 no 1183 0.368798628234163 1791 16459633 SGTC_2243 6634756 200 µM 0.333834292937758 0.359351933883894 no 1184 0.369252302221046 1836 885676 SGTC_956 1185-0240 191 µM 0.333426819830116 0.359514278000709 no 1185 0.369406060495612 1741 1416193 SGTC_17 0960-0276 49.807 µM 0.333065007773074 0.359658451246646 no 1186 0.369542606275198 1740 6821114 SGTC_353 1988-1175 58.3 µM 0.332712806725921 0.359798813927684 no 1187 0.369675540721152 1674 2788357 SGTC_569 4130-2812 160 µM 0.332008328349306 0.360079626418285 no 1188 0.369941485133978 1832 743552 SGTC_2907 7721985 69.9 µM 0.330317075338323 0.36075408569216 no 1189 0.370580196050977 1679 3267881 SGTC_2111 5486399 200 µM 0.329435504962328 0.361105821424274 no 1190 0.370913267520393 1702 689674 SGTC_1232 0279-0259 161 µM 0.327555023460854 0.361856502628262 no 1191 0.371624066674971 1700 1560000 SGTC_3064 1327-0027 10 µM 0.326106590925036 0.362435074266832 no 1192 0.372171855272384 1730 16000455 YPR107C YTH1 SGTC_2910 7948405 25.97 µM 0.323573724314457 0.363447574333886 no 1193 0.373130391781552 1868 2971328 SGTC_680 0417-1641 114 µM 0.323433357593367 0.363503713173467 no 1194 0.373183535112973 1717 2835990 SGTC_3080 9117754 49.47 µM 0.323275096269795 0.363567012369086 no 1195 0.373243456297126 1851 9550191 SGTC_3307 9126885 69.2785 µM 0.319695343893164 0.364999784612889 no 1196 0.374599644868322 1674 24824909 SGTC_923 1900-2434 73.3 µM 0.319421149534791 0.365109607146253 no 1197 0.374703587582224 1706 5910570 SGTC_2372 9071633 200 µM 0.319371026800779 0.365129683903923 no 1198 0.374722589296763 1843 21321366 SGTC_2634 4'-methoxyflavone 100 µM 0.316408332615927 0.366317051780799 no 1199 0.375846296548922 1737 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2640 pentamidine 10.38 µM 0.316178787377165 0.366409100930718 no 1200 0.375933403857074 1898 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3265 9137266 49.47 µM 0.316101143408199 0.366440238412623 no 1201 0.375962869445983 1928 17224265 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.315491307820582 0.366684830714987 no 1202 0.376194324850323 1772 688788 SGTC_2400 5203494 178.7 µM 0.314659979699333 0.367018346240833 no 1203 0.376509916672995 1695 6777674 SGTC_2694 st077685 81.9 µM 0.31446133364278 0.367098054725646 no 1204 0.376585339644673 1703 2838096 SGTC_475 α-linolenic acid 10 µM 0.314272598301885 0.367173791755573 no 1205 0.37665700402896 1836 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3093 9117344 49.47 µM 0.313493045259391 0.367486670955741 no 1206 0.376953051839704 1777 24824913 SGTC_904 1141-0088 396 µM 0.313463424691779 0.36749856111921 no 1207 0.376964302154798 1695 1378119 SGTC_2857 9024691 58.44 µM 0.310840898346497 0.368551786872663 no 1208 0.377960788172618 1759 16478292 SGTC_896 0964-0007 44.5 µM 0.309943105308484 0.368912574599953 no 1209 0.378302111229903 1868 6756758 SGTC_1463 k081-0032 34.1 µM 0.308275935799559 0.369582850770821 no 1210 0.378936187709094 1685 977755 SGTC_3101 9120531 49.47 µM 0.307977829299351 0.369702744670059 no 1211 0.379049601294115 1864 24824904 SGTC_61 0978-8327 98.565 µM 0.306957687059641 0.370113126149229 no 1212 0.37943778960671 1839 6150059 YHR072W ERG7 SGTC_783 0848-0141 92.7 µM 0.306508582716942 0.370293838175506 no 1213 0.379608723022785 1750 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1777 st045864 34.765 µM 0.306282926181325 0.370384649376269 no 1214 0.37969461894659 1773 4691462 SGTC_2375 9072683 200 µM 0.305446377814126 0.370721365423923 no 1215 0.380013101974927 1933 16798029 SGTC_610 4215-0184 155 µM 0.30493219010352 0.370928378416458 no 1216 0.380208899208626 1785 5605015 SGTC_609 0986-0026 86.3 µM 0.304313402089768 0.371177553230765 no 1217 0.380444567831218 1830 2848610 SGTC_459 nigericin 15.3 µM 0.303767486412639 0.371397428514714 no 1218 0.380652519498941 1794 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_547 1120-0019 610 nM 0.303139375325413 0.371650461092386 no 1219 0.380891823927447 1766 3676939 SGTC_2789 5281112 71.43 µM 0.302441320626465 0.371931735303069 no 1220 0.381157829674999 1702 765948 SGTC_439 amiodarone 34.4 µM 0.301825629512032 0.372179878671983 no 1221 0.38139249598186 1843 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2741 miltefosine 3.04 µM 0.300474377959472 0.372724662593491 no 1222 0.381907668717365 1802 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2916 7875993 68.79 µM 0.300194109132026 0.372837690468958 no 1223 0.382014549109156 1941 1299250 SGTC_517 1365-0151 113 µM 0.300138416344341 0.372860151771806 no 1224 0.382035788600065 1801 768657 SGTC_692 k241-0027 77.8 µM 0.299585223643288 0.373083281835798 no 1225 0.382246778297572 1871 3600480 SGTC_1185 1319-0113 81.3 µM 0.299099304431312 0.373279312291815 no 1226 0.382432138494383 1832 4672763 SGTC_2785 7756463 72.73 µM 0.298499524969678 0.373521321697324 no 1227 0.382660969309464 1734 2201551 SGTC_1143 3454-2408 5.08 µM 0.297572124173452 0.373895623613597 no 1228 0.383014876458649 1797 X1143 SGTC_462 ag-879 158 µM 0.296487278118467 0.37433362187429 no 1229 0.383428990530401 1891 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_942 3253-1115 227 µM 0.296205762446086 0.374447308199679 no 1230 0.383536474203115 1879 46497897 SGTC_2459 5811157 9.22 µM 0.295666516796483 0.374665105791231 no 1231 0.383742385107884 1799 2870684 YBR192W RIM2 SGTC_1968 st069590 43.6 µM 0.293785356729592 0.375425206005128 no 1232 0.384460962609556 1880 6384066 SGTC_937 3122-0005 46.7 µM 0.292956103120497 0.375760427475582 no 1233 0.384777852472525 1920 759535 SGTC_2877 9040724 71.43 µM 0.29057704600725 0.376722668731473 no 1234 0.385687408775348 1929 6463895 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.290489241098746 0.37675819729372 no 1235 0.385720990234957 1824 6708739 YPR165W RHO1 SGTC_974 1326-0144 138 µM 0.290087563886495 0.376920741533264 no 1236 0.385874624763985 1764 5411856 SGTC_3114 9122766 49.47 µM 0.289445353565372 0.377180666135818 no 1237 0.386120296196696 1756 17176985 SGTC_1656 st012921 11 µM 0.28900877012995 0.377357398253005 no 1238 0.386287333108427 1880 6732821 SGTC_1670 st016595 4.04 µM 0.288783583334638 0.377448565532737 no 1239 0.38637349786379 1892 597879 SGTC_1454 4239-0054 42.6 µM 0.286516546051732 0.378366759324206 no 1240 0.387241261255067 1913 1340767 SGTC_2143 5623677 140.463 µM 0.285670809625013 0.37870947517147 no 1241 0.387565131967969 1887 5375313 SGTC_1819 st053448 58.6 µM 0.285096696892105 0.378942175947111 no 1242 0.387785030294347 1825 2857616 SGTC_1695 st026914 34.495 µM 0.284618438417698 0.379136058350146 no 1243 0.387968241729435 1795 3289191 SGTC_2010 4012422 159 µM 0.283288437537342 0.379675390468479 no 1244 0.388477869962283 1844 952393 SGTC_2466 5983409 37.09 µM 0.282287435317163 0.380081463993984 no 1245 0.388861559571793 1789 2879657 SGTC_620 0109-0052 432 µM 0.28161353559925 0.380354917348316 no 1246 0.389119930103653 1912 493037 SGTC_217 ketoconazole 989 nM 0.280573117798538 0.380777212897728 no 1247 0.38951891850175 1836 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2848 9016370 25.97 µM 0.279979318403383 0.381018294060095 no 1248 0.389746686057767 1975 7894410 SGTC_2176 5809774 33.9695 µM 0.279549098538654 0.381192991179618 no 1249 0.389911731995368 1950 2870539 SGTC_1348 1493-0373 93.8 µM 0.279510245299657 0.381208769302858 no 1250 0.389926638303579 1841 3010129 SGTC_91 0417-1751 58.384 µM 0.279463242931852 0.381227857014094 no 1251 0.389944671296603 1881 6795624 SGTC_973 1325-0077 65.9 µM 0.278871150833764 0.381468330972416 no 1252 0.390171854438636 1913 2835149 SGTC_2162 5663267 200 µM 0.276268714278017 0.382525833383763 no 1253 0.391170841767362 1906 6456493 SGTC_2825 7998094 58.44 µM 0.275851523500037 0.382695440959322 no 1254 0.391331054175199 1816 2987815 SGTC_776 4476-4378 112 µM 0.27477595793085 0.383132812404884 no 1255 0.391744185081613 1812 2892008 SGTC_3014 9081533 49.47 µM 0.273179654152832 0.383782213079241 no 1256 0.392357559500183 1936 21367265 SGTC_845 0330-0138 4.51 µM 0.273177057061617 0.383783269882015 no 1257 0.392358557642226 1943 9039800 SGTC_1788 fluconazole 20 µM 0.272966564901214 0.383868925772762 no 1258 0.39243945860848 1785 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3297 9117502 71.43 µM 0.272623865857798 0.384008392945847 no 1259 0.392571182168597 1878 7453720 SGTC_1579 chlormadinone acetate 49.4 µM 0.272360549521768 0.384115564190201 no 1260 0.392672401683218 1946 45114258 A steroidal progestin. SGTC_1801 st050089 28.441 µM 0.271178758607582 0.384596668828154 no 1261 0.393126774630785 1842 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1501 4491-0275 38.4 µM 0.270393177415306 0.384916575728411 no 1262 0.393428894162335 1946 5104718 SGTC_2743 auranofin 4.32 µM 0.270152652623978 0.385014538686033 no 1263 0.393521408247681 1896 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1116 jasmonic acid  1.58368 µM 0.269683277062135 0.38520573104023 no 1264 0.393701963497467 1889 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_756 0508-1999 28.3 µM 0.267304424880929 0.386175145269399 no 1265 0.394617390062127 1727 6753853 SGTC_2508 celastrol 40.54 µM 0.265385118677384 0.386957806945903 no 1266 0.395356399434124 1911 122724 Celastrol is a natural product and antioxidant. SGTC_897 1000-0139 31.4 µM 0.26498503704084 0.38712101172076 no 1267 0.395510494313952 1957 6151020 SGTC_3107 9121808 49.47 µM 0.264086129946846 0.387487774459412 no 1268 0.395856775659972 1959 662681 SGTC_59 0330-0160 1.33 µM 0.263785521701915 0.387610447939601 no 1269 0.39597259578119 1883 4293482 SGTC_1763 st044482 94.5 µM 0.263192474418775 0.387852494068825 no 1270 0.396201115466873 1912 88505 SGTC_10 0279-0212 42.575 µM 0.261961729139355 0.388354949029176 no 1271 0.396675473899991 1837 39851 YBR002C RER2 SGTC_2274 7947094 46.08 µM 0.261050659865188 0.38872701586593 no 1272 0.397026720178627 1927 2971028 SGTC_775 4577-0580 57.3 µM 0.260573555302106 0.388921898868179 no 1273 0.39721069256217 1897 2006902 SGTC_130 0136-0219 337.655 µM 0.257546798133961 0.390158888266842 no 1274 0.398378346819448 1986 234244 SGTC_2957 9076800 11.52 µM 0.257470383911924 0.390190132047915 no 1275 0.398407837519481 1797 16459615 SGTC_1276 0871-0068 94.2 µM 0.256965838809246 0.390396445166922 no 1276 0.398602572218629 1930 3414906 SGTC_2299 7976368 114.88 µM 0.256701122284881 0.390504702531024 no 1277 0.398704752557443 1938 2979718 SGTC_917 harmaline 728.087 nM 0.254309106695286 0.391483315208311 no 1278 0.399628382452223 1903 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2811 7967822 32.47 µM 0.252422021082024 0.39225583805741 no 1279 0.400357440377823 1912 2232244 SGTC_1908 st060353 56.5 µM 0.252296489373686 0.392307242516139 no 1280 0.400405950731453 2019 4227716 SGTC_2906 7926292 26.41 µM 0.251867977663039 0.392482729564562 no 1281 0.400571555957625 1854 2966319 SGTC_2938 9059746 27.26 µM 0.25178635913408 0.392516157022987 no 1282 0.40060310077511 1891 6471769 SGTC_2946 9065502 71.43 µM 0.251362475734045 0.392689774280908 no 1283 0.400766938267013 1895 16489101 SGTC_1889 st059080 5.18 µM 0.24996812051775 0.393261034957102 no 1284 0.401306001145562 2017 176925 Isolated from Daphnopsis sellowiana. SGTC_368 fentichlor 4.58 µM 0.248234854796862 0.393971466040389 no 1285 0.401976349950814 1827 7329 A pesticide. SGTC_854 0422-0053 192 µM 0.24717096813151 0.394407706967947 no 1286 0.40238795620681 1908 3596728 SGTC_1617 st002906 78 µM 0.246581736972493 0.394649375030888 no 1287 0.402615969983971 1850 5150859 SGTC_2692 st077426 47.7 µM 0.244612093679226 0.395457501004026 no 1288 0.403378399547428 1973 25238571 SGTC_1655 st012546 55.1 µM 0.244311727268696 0.395580778102479 no 1289 0.403494700790534 1917 720985 YLR208W SEC13 SGTC_2512 diallyl trisulfide 49.23 µM 0.24429313870741 0.395588407607555 no 1290 0.403501898522951 1969 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2332 7982454 138.89 µM 0.241843879726238 0.396594032477562 no 1291 0.404450568408133 1943 2981748 SGTC_187 1488-2104 32.728 µM 0.241789870612134 0.39661621549825 no 1292 0.404471494076944 1959 2852859 SGTC_1718 roemerine 11.9335 µM 0.240885165181905 0.396987852463746 no 1293 0.404822060057308 1937 235224 An aporphine alkaloid with mutagenic activity. SGTC_2642 cholecalciferol 100 µM 0.240621786422279 0.397096061392499 no 1294 0.404924131551667 1954 9821465 A vitamin D precursor, similar to steriods. SGTC_1912 st060209 90.8 µM 0.240333387477634 0.397214558928623 no 1295 0.405035906948755 1814 688787 SGTC_110 0850-0284 111.64 µM 0.239810908950239 0.397429259386869 no 1296 0.405238424797579 1980 3906265 SGTC_1224 0823-0416 294 µM 0.239416682779244 0.397591278083676 no 1297 0.405391247563577 1961 3598164 SGTC_3071 9117417 49.47 µM 0.239390129054055 0.397602191743797 no 1298 0.405401541700657 2016 45595590 YGL055W OLE1 SGTC_1550 gossypolone 36.6 µM 0.238248470591462 0.39807149246461 no 1299 0.405844192573783 1975 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1842 st055362 61.2 µM 0.237625034495716 0.398327830201551 no 1300 0.406085965936461 1939 676032 SGTC_3055 9094636 49.47 µM 0.236882041077613 0.39863338353298 no 1301 0.406374151332891 1929 25236176 SGTC_1134 3477-0009 42.5 µM 0.23667674153394 0.398717823187175 no 1302 0.406453789966851 2030 3973534 SGTC_95 0471-0001 561.058 µM 0.234756234693191 0.399507956314929 no 1303 0.407198969072692 1795 4015405 SGTC_3076 9116187 49.47 µM 0.232810467868324 0.400308901830546 no 1304 0.407954292035267 2008 27241210 SGTC_1716 st033144 30.6155 µM 0.23212278089837 0.400592078275763 no 1305 0.408221325725555 2014 674617 SGTC_3230 9131665 49.47 µM 0.230914023086986 0.401089948368237 no 1306 0.408690798135922 1925 15943720 SGTC_3001 9076041 71.4286 µM 0.230468761600809 0.401273385755392 no 1307 0.40886376740074 1896 16004211 SGTC_3277 9138724 49.47 µM 0.23020245577138 0.401383107972969 no 1308 0.408967226835451 1924 15943418 SGTC_1298 1079-1278 263 µM 0.229802154654551 0.401548052998123 no 1309 0.409122755178628 1889 2840950 SGTC_1088 bifonazole 369 nM 0.229519077906056 0.401664706035196 no 1310 0.409232747166022 1972 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_53 0973-0023 39.979 µM 0.227728864842121 0.402402637091805 no 1311 0.409928515535159 2061 674768 SGTC_66 0109-0187 42.4 µM 0.227538664195198 0.402481058846312 no 1312 0.410002453945308 1779 759417 SGTC_1606 st000094 49.2 µM 0.227511854146407 0.402492113230918 no 1313 0.410012876314364 2044 1242210 SGTC_291 SEC14.278 35.5 µM 0.227249190659872 0.402600419401911 no 1314 0.410114989739552 1996 1068044 SGTC_631 k072-0230 41.5 µM 0.227174894007793 0.402631056101265 no 1315 0.410143874516342 1945 5773147 SGTC_323 4013-0906 34.3 µM 0.226871986845657 0.402755967992276 no 1316 0.410261642683271 2028 2910086 SGTC_2492 derrusnin 100 µM 0.226468316768827 0.402922447600772 no 1317 0.410418599338253 1902 1715307 Part of coumarin class of compounds. SGTC_354 2783-3500 4.88 µM 0.226197928163402 0.403033969771837 no 1318 0.410523740971188 1825 6740761 SGTC_1302 1159-0335 255 µM 0.226001857469588 0.403114844347421 no 1319 0.410599987825631 1882 649284 SGTC_127 0180-0333 59.125 µM 0.225576416142476 0.403290343193837 no 1320 0.410765442641123 2027 771601 SGTC_404 fumagillin 50 µM 0.225114034815407 0.403481102252741 no 1321 0.410945281488391 1923 12015870 A methionine aminopeptidase binder. SGTC_2626 ethyl orsellinate 100 µM 0.225075453628923 0.40349702026384 no 1322 0.410960288122927 1887 75653 A natural product. SGTC_686 1319-0111 510 µM 0.224663537071919 0.403666980734141 no 1323 0.411120516333069 2004 4562600 SGTC_3148 9097893 49.47 µM 0.224440256760918 0.403759115800836 no 1324 0.411207374599588 1807 17174100 SGTC_2319 6033012 152.6 µM 0.224438725566625 0.40375974765595 no 1325 0.411207970264463 1855 847246 SGTC_2471 5466956 24.79 µM 0.223766470739916 0.404037181268179 no 1326 0.411469510447864 1945 724419 SGTC_450 aminopyrene 156 nM 0.222215816922178 0.404677306252779 no 1327 0.412072940895363 2001 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_3069 9117009 49.47 µM 0.218533035660191 0.406198614031264 no 1328 0.413506910763754 2044 41904981 SGTC_2354 9060492 162 µM 0.21806520663574 0.406391969887315 no 1329 0.413689153060369 2011 6471895 SGTC_2038 4100038 30.985 µM 0.218055631444955 0.40639592759562 no 1330 0.413692883260004 1941 3596803 SGTC_2627 acetyl isogambogic acid 100 µM 0.21781828208252 0.406494034131624 no 1331 0.413785349755201 1847 6857789 A caspase activator and apoptosis inducer. SGTC_3045 9092950 49.47 µM 0.217812876179172 0.406496268688644 no 1332 0.413787455841146 2055 44120432 SGTC_1441 4106-0040 13 µM 0.217683189886033 0.40654987607512 no 1333 0.413837981068729 2006 2904180 SGTC_839 0122-0028 230 µM 0.216967375961048 0.40684579784283 no 1334 0.414116884768195 1943 759448 SGTC_1148 3909-7663 27.7 µM 0.216781747773295 0.406922546341218 no 1335 0.414189218448386 2032 4084526 SGTC_111 0083-0039 52.457 µM 0.216222417485951 0.407153824628914 no 1336 0.414407190103315 2034 759313 SGTC_3203 9113543 49.47 µM 0.215642622010373 0.407393599271063 no 1337 0.414633164892312 1932 17018012 SGTC_1906 st060206 94.7 µM 0.215246574375416 0.407557404876792 no 1338 0.414787540364708 2027 5133468 SGTC_2190 6049624 200 µM 0.21522800695917 0.407565084771294 no 1339 0.414794778084065 1988 2265554 SGTC_2449 5812982 45.77 µM 0.214350109790301 0.407928242979344 no 1340 0.415137022015764 1974 776185 SGTC_682 0kpi-0099 17 µM 0.213850795611536 0.408134828730934 no 1341 0.415331705964769 1888 1714895 YML126C ERG13 SGTC_599 1935-0052 86.5 µM 0.213445916675849 0.40830236169193 no 1342 0.41548958462242 1944 9557311 SGTC_684 1140-0066 328 µM 0.213390057273156 0.408325476809418 no 1343 0.415511367532381 1907 6813534 SGTC_758 0868-0029 16 µM 0.213387988303302 0.408326332973666 no 1344 0.415512174352012 2047 762687 SGTC_107 0358-0022 2.6945 µM 0.212845610011034 0.40855079062183 no 1345 0.415723693554072 2025 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_637 1181-0519 7.26 µM 0.212780929799145 0.408577559862417 no 1346 0.415748919473972 1966 6252091 YGR060W ERG25 SGTC_2834 9001755 58.44 µM 0.212598285636209 0.408653153221239 no 1347 0.415820154371057 1889 2989575 SGTC_3173 9105693 49.47 µM 0.212462563945311 0.408709328356283 no 1348 0.415873090351851 1985 17096658 SGTC_1590 st077108 57.8 µM 0.211757856404195 0.409001036555945 no 1349 0.416147974287901 2039 5489485 SGTC_1963 st076565 50.3 µM 0.21059585190966 0.409482149284274 no 1350 0.416601324710614 1913 4914280 SGTC_1012 4112-3522 18 µM 0.209617707390693 0.409887242931212 no 1351 0.416983029088178 2047 3112398 SGTC_1696 st025591 34.7925 µM 0.207408824202656 0.410802394112686 no 1352 0.41784529586041 1941 2787147 SGTC_2647 atorvastatin 60.16 µM 0.206999537671256 0.410972017028167 no 1353 0.418005109782316 2014 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1029 k015-0030 64.7 µM 0.206306481621549 0.411259282086183 no 1354 0.418275757919417 1962 2208316 SGTC_1129 3453-1384 223 µM 0.205283584265365 0.411683350095346 no 1355 0.418675284401903 1961 1084452 SGTC_1260 0700-1617 7.75 µM 0.203593411989495 0.412384279701938 no 1356 0.419335620895638 1951 2853078 SGTC_121 0557-0495 61.343 µM 0.202740497660327 0.412738097192697 no 1357 0.419668933946043 1904 3104427 SGTC_3314 9135860 59.4275 µM 0.20260185494008 0.412795617554007 no 1358 0.419723120019565 2070 25252478 SGTC_1439 4092-1168 46 µM 0.202547191785126 0.412818296824753 no 1359 0.419744484572555 2005 2886240 SGTC_1632 st005650 90 µM 0.202183519824547 0.41296918858425 no 1360 0.419886628177215 1948 2759605 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.201981141129463 0.41305316344762 no 1361 0.419965733763982 1933 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_204 PMA1.184 62.41 µM 0.201938364076965 0.413070913835045 no 1362 0.419982454830592 1986 2252213 YGL008C PMA1 SGTC_1338 1486-1223 76 µM 0.201429277662042 0.41328217346462 no 1363 0.42018146203969 2011 3444526 SGTC_3165 9101544 49.47 µM 0.200546548837719 0.413648545934921 no 1364 0.420526578322277 2012 5002184 SGTC_1574 spiramycin 23.7 µM 0.199682222311424 0.414007353473721 no 1365 0.420864559151168 1984 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1571 st070080 73.4 µM 0.197410304733673 0.414950835384737 no 1366 0.421753233140959 2015 4315245 SGTC_1234 0326-0494 15.5 µM 0.195798105290534 0.41562064757289 no 1367 0.422384096564984 2041 1547813 SGTC_1505 k297-0037 20.6 µM 0.195779424642594 0.415628410166358 no 1368 0.422391407586199 1915 4089396 SGTC_2262 9014885 67.46 µM 0.1903767198784 0.417874830734508 no 1369 0.424506969453155 2070 6457424 SGTC_31 0508-1974 57.237 µM 0.190263137101524 0.417922086990717 no 1370 0.424551469155998 2029 6810525 SGTC_2373 9071805 200 µM 0.189399051130629 0.418281629792376 no 1371 0.424890034049118 2119 10149009 SGTC_2370 9071495 200 µM 0.188730285146123 0.418559947608925 no 1372 0.425152107005493 1911 21791103 SGTC_1594 piperine 70.1 µM 0.188350019781233 0.418718219403735 no 1373 0.425301138417729 1927 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2773 thioridazine 9.09 µM 0.187963728117767 0.418879012901282 no 1374 0.425452542551635 2099 5452 An antipsychotic. SGTC_2379 9035213 200 µM 0.183105149944478 0.420902539514112 no 1375 0.427357757509941 2106 646551 SGTC_1313 1220-0047 237 µM 0.182783488608653 0.421036581149819 no 1376 0.427483952265242 2017 3528706 SGTC_3236 9132701 49.47 µM 0.181769835206922 0.421459047208257 no 1377 0.42788167906925 1960 24282524 SGTC_1312 1218-2183 165 µM 0.180883698976529 0.421828441312426 no 1378 0.428229432061239 2096 6744073 SGTC_268 camptothecin 39.6153 µM 0.1807757510061 0.421873445131723 no 1379 0.428271798695615 2081 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_360 0957-0399 1.01 µM 0.180024856165451 0.422186523552002 no 1380 0.428566527293438 2057 6752301 YPR165W RHO1 SGTC_940 3232-1287 54.8 µM 0.179901477711719 0.422237969726996 no 1381 0.428614957541893 2118 1585493 YIL048W NEO1 SGTC_2827 7993847 71.43 µM 0.179330057070291 0.422476257195375 no 1382 0.428839273627831 1995 2985692 SGTC_528 3492-0019 172 µM 0.179303611715152 0.422487285830324 no 1383 0.428849655536465 2091 2869262 SGTC_583 1488-1091 88.9 µM 0.179187406045937 0.422535748365244 no 1384 0.428895276102377 2130 4303273 SGTC_1460 k062-0059 9.15 µM 0.178807725192804 0.422694099039792 no 1385 0.429044339609344 2014 1373085 SGTC_3100 9120536 49.47 µM 0.176791371170251 0.423535253586252 no 1386 0.429836133550995 2103 16421196 SGTC_2974 9094440 9.66 µM 0.175706431606726 0.423987998083731 no 1387 0.430262291114069 2039 25236134 SGTC_1678 st019265 80.2 µM 0.175323943595141 0.42414763400902 no 1388 0.430412549439268 2122 5367020 SGTC_2078 5212016 200 µM 0.175220582128371 0.424190775284925 no 1389 0.430453156156993 2141 1899708 SGTC_738 1315-0003 72.4 µM 0.174776764182852 0.424376027483081 no 1390 0.430627523394722 2094 6251474 SGTC_1409 3909-8004 61.9 µM 0.174478302771107 0.424500616415031 no 1391 0.430744790551849 2011 2119279 SGTC_2787 5284540 71.43 µM 0.174178768926017 0.424625660605304 no 1392 0.430862485213825 1980 736958 SGTC_2217 6934799 96.0675 µM 0.17332707038951 0.424981254336381 no 1393 0.431197173306933 2105 675606 SGTC_3244 9134489 49.47 µM 0.172722848178294 0.425233560949631 no 1394 0.431434641731017 1960 16584271 SGTC_184 1494-0393 24.714 µM 0.172546513128637 0.42530719940454 no 1395 0.431503948735481 1959 3090647 SGTC_1346 1488-2224 62.4 µM 0.171471418276387 0.425756221018408 no 1396 0.431926551247447 2110 3722427 SGTC_1813 st051246 8.6015 µM 0.170966001189822 0.425967345653192 no 1397 0.432125249535855 2109 5291959 SGTC_1466 k213-0079 57.5 µM 0.170865551241785 0.426009308495125 no 1398 0.432164742200089 1998 3657981 SGTC_1949 st076024 69.1 µM 0.170543464177128 0.42614386561726 no 1399 0.432291377758735 2034 2921930 SGTC_705 1124-0212 310 µM 0.169456827394084 0.426597889200642 no 1400 0.43271866397282 2112 9554485 SGTC_3104 9120930 49.47 µM 0.16743198560735 0.427444177007192 no 1401 0.433515079754487 2021 17014836 SGTC_506 n9-isopropylolomoucine 153 µM 0.167130819077335 0.427570078954232 no 1402 0.433633558466261 2154 6610355 SGTC_2175 5807670 165.306 µM 0.166922747198943 0.427657067214213 no 1403 0.433715417288306 2101 241186 SGTC_3117 9124945 49.47 µM 0.166871273599193 0.427678587238179 no 1404 0.433735668268777 1910 17592065 SGTC_962 1254-0300 21.5 µM 0.166492378184054 0.427837002018618 no 1405 0.433884740395821 2002 7340576 SGTC_415 dibenzyl ketone 100 µM 0.165184150194716 0.428384056599225 no 1406 0.434399520101462 2098 7593 SGTC_1064 honokiol 6.76 µM 0.16510664165675 0.428416472252334 no 1407 0.434430022736155 2003 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_669 0108-0021 26.2 µM 0.165023744488696 0.428451142075075 no 1408 0.434462646439091 2201 17201 SGTC_2892 9047358 58.44 µM 0.164857113321834 0.428520833375977 no 1409 0.434528224524835 1999 6466771 SGTC_3131 9127911 49.47 µM 0.164411928496627 0.428707037019666 no 1410 0.434703436885807 2041 45595681 SGTC_1112 tnp00069 1.16933 µM 0.163644373370964 0.429028112973717 no 1411 0.435005555326317 2100 145826 SGTC_1440 4100-1550 40 µM 0.163127616556792 0.429244303963915 no 1412 0.435208978081082 2089 742806 SGTC_555 4296-0685 37 µM 0.16298537776791 0.429303814879328 no 1413 0.435264973787263 2106 2908540 YHR072W ERG7 SGTC_2458 5808907 16.39 µM 0.162519561380332 0.429498717821692 no 1414 0.435448362646676 2134 2731747 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.162517521346525 0.429499571433169 no 1415 0.435449165825181 2032 65057 A dermal irritant. YDR527W RBA50 SGTC_2964 9083345 53.42 µM 0.162399702798031 0.429548870815096 no 1416 0.435495552432502 1982 17741579 SGTC_2725 haloperidol 53.21 µM 0.161064098728696 0.43010781069165 no 1417 0.436021458041172 2112 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_502 l-744,832 89.3 µM 0.16102332584017 0.430124876036442 no 1418 0.436037514501668 2121 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2960 9079389 5.97 µM 0.159987218982397 0.430558578526228 no 1419 0.436445571152177 2109 16457355 SGTC_1019 4262-0212 3.4 µM 0.159882844016292 0.430602273347559 no 1420 0.436486681576299 2138 4677213 SGTC_1683 st010134 710 nM 0.157211077533858 0.431721051154926 no 1421 0.437539249126273 1942 3818134 SGTC_1860 st056228 74.6 µM 0.155502672804371 0.432436717782281 no 1422 0.438212523490013 2006 688679 SGTC_2927 9011802 47.9 µM 0.155233956193265 0.432549305909354 no 1423 0.438318439788075 1965 43912568 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.152598814829969 0.433653678408007 no 1424 0.439357329840887 1983 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_946 3434-1334 87.4 µM 0.150902669165581 0.434364797901877 no 1425 0.440026247455528 2095 4047976 SGTC_1428 4049-0204 61.7 µM 0.150852421872564 0.434385867639354 no 1426 0.440046066357453 2131 X1428 SGTC_513 4245-1575 41.7 µM 0.150151718365705 0.434679706622855 no 1427 0.440322458551615 2104 719745 SGTC_3246 9135460 32.98 µM 0.149061340759513 0.435137026573771 no 1428 0.440752615313362 2092 41446951 SGTC_149 3970-0822 46.1 µM 0.148577542730003 0.435339966211143 no 1429 0.440943497300626 2109 3114250 YBL034C STU1 SGTC_143 4032-1194 15.74 µM 0.147141322395846 0.435942520286426 no 1430 0.441510237133971 1985 1806963 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.146789341798703 0.436090213507379 no 1431 0.441649148782598 2104 688751 SGTC_166 k072-0058 166.424 µM 0.146276677444981 0.436305346557955 no 1432 0.441851488255228 2181 5846229 SGTC_1026 k007-1105 30.6 µM 0.145419012512374 0.436665296798253 no 1433 0.44219002720165 2034 7066794 SGTC_2482 5981709 142.65 µM 0.143096044645945 0.437640477198852 no 1434 0.443107164355662 2081 877755 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.142559041973504 0.437865964707141 no 1435 0.443319223384233 2135 66535 A nucleotide analog. SGTC_1671 st016596 74.5 µM 0.141808982710936 0.438180948469896 no 1436 0.443615444301276 2127 2829167 SGTC_1810 st050138 53 µM 0.140791145855886 0.43860844674126 no 1437 0.444017468987161 2172 3444541 SGTC_2700 st077718 96.8 µM 0.14062556003173 0.438678000680441 no 1438 0.444082877451926 2011 904970 SGTC_2499 avocadenofuran 51.48 µM 0.139978718373052 0.438949723139578 no 1439 0.444338402550391 2113 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2318 6029776 164 µM 0.13980060223158 0.439024550459273 no 1440 0.444408768728608 2088 818325 SGTC_2545 solidagenone 89.61 µM 0.139389297067087 0.439197349763097 no 1441 0.444571264749812 2149 6708572 An anti ulcer agent SGTC_629 3448-6466 76.7 µM 0.139218379464437 0.439269159815146 no 1442 0.444638792610959 2121 573744 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.137612182765274 0.439944091485838 no 1443 0.445273463342264 2053 279621 SGTC_720 r052-1644 49.9 µM 0.137445900604722 0.440013974063861 no 1444 0.445339175926942 2085 1422863 YOR257W CDC31 SGTC_2 0422-0095 29 µM 0.137216316647437 0.440110463244689 no 1445 0.445429907040597 2089 6790840 SGTC_1414 3917-0015 5.4 µM 0.137205943179547 0.440114823073325 no 1446 0.445434006681568 2135 6618702 SGTC_1990 st072050 59.8 µM 0.135405133763061 0.440871788570435 no 1447 0.446145782679959 2006 17233948 SGTC_2759 disulfiram 3.38 µM 0.135010258593416 0.441037802291372 no 1448 0.446301881706067 2091 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_231 b-estradiol 524 µM 0.134906083191843 0.441081601521998 no 1449 0.44634306491588 2044 450 A steroid. SGTC_3311 9131146 2.8755 µM 0.13463308756328 0.441196382500238 no 1450 0.446450989838628 2065 4900406 YPR165W RHO1 SGTC_2746 daunorubicin 9.88 µM 0.132644059403144 0.442032817641501 no 1451 0.447237442952771 2164 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2674 ligustilide 100 µM 0.132057504324129 0.442279527969549 no 1452 0.447469404047629 2114 5319022 A signalling regulator. SGTC_976 1348-1067 47.6 µM 0.131662394482771 0.442445727339007 no 1453 0.447625665681545 2138 5310671 YGL099W LSG1 SGTC_2867 9039098 71.43 µM 0.129278122526545 0.443448863678705 no 1454 0.448568790924438 2163 6463460 SGTC_992 3909-8734 162 µM 0.129271897766945 0.443451483103233 no 1455 0.448571253580029 2056 4288319 SGTC_2061 5245884 80.95 µM 0.127822536865129 0.444061451838967 no 1456 0.449144707261158 2123 573863 SGTC_486 niguldipine 82 µM 0.127800257623152 0.444070829175845 no 1457 0.449153523091273 2166 1236 A calcium channel blocker. SGTC_201 4262-0159 12.803 µM 0.127761664566638 0.444087073074234 no 1458 0.449168794308916 2193 1341029 SGTC_1688 st021091 57.6 µM 0.127641256616479 0.44413775363642 no 1459 0.4492164400476 2198 3656366 SGTC_1115 galangin 695.678 nM 0.126661879268268 0.44455001438505 no 1460 0.449604009349971 2168 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2380 9035439 200 µM 0.126618835048779 0.444568134870793 no 1461 0.44962104435803 2147 6462575 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.126202568076301 0.444743378303948 no 1462 0.449785789295136 2072 4330530 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.125939037631878 0.444854327065087 no 1463 0.449890090554898 2152 6708784 An antioxidant flavonoid SGTC_1073 triclabendazole 3.09 µM 0.125808653299716 0.444909221676226 no 1464 0.449941695930416 2072 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1376 2910-0861 41.3 µM 0.125124397677354 0.445197325323252 no 1465 0.450212534263991 2158 1112859 SGTC_769 0302-0231 76 µM 0.124498911519222 0.445460709603979 no 1466 0.450460131078824 2159 571869 YER009W NTF2 SGTC_3341 9147222 25.867 µM 0.123420961788511 0.445914676981333 no 1467 0.450886879432805 2103 1939759 SGTC_909 3448-9333 149 µM 0.123009302816928 0.446088061642076 no 1468 0.451049865666786 2091 3344074 SGTC_2868 9035608 32.47 µM 0.122142300183975 0.446453263989332 no 1469 0.451393160975814 2196 6462614 SGTC_525 k781-2675 26.7 µM 0.121841398830875 0.446580021504885 no 1470 0.451512313327183 2217 3651118 YDL195W SEC31 SGTC_704 1310-0270 142 µM 0.121521734605495 0.446714689035602 no 1471 0.451638900275429 2067 5718033 SGTC_1903 st060211 78.3 µM 0.120617403062818 0.447095697322383 no 1472 0.451997041917671 2191 688960 SGTC_1769 st044406 64.4 µM 0.12035557380651 0.447206019001431 no 1473 0.4521007412384 2039 670903 SGTC_3087 9117406 49.47 µM 0.11982280236067 0.447430514695411 no 1474 0.452311759203761 2070 42546093 SGTC_2715 st079500 56.4 µM 0.119538913310227 0.447550144861374 no 1475 0.4524242063392 2131 28246688 SGTC_811 0416-0114 265 µM 0.119285208459109 0.447657059515838 no 1476 0.452524700882641 2058 6612453 SGTC_2860 9025725 38.96 µM 0.11925930894045 0.447667974137241 no 1477 0.452534960062644 2025 40546248 SGTC_2884 9058502 51.95 µM 0.11910197719401 0.447734278013969 no 1478 0.452597282160499 2107 6471554 SGTC_2452 5863136 48.41 µM 0.118869022370025 0.447832454193764 no 1479 0.452689562142317 2167 2184096 SGTC_508 roscovitine 141 µM 0.118355803754086 0.448048755651182 no 1480 0.452892871532838 2178 160355 A CDKinase inhibitor. SGTC_1712 st032288 53.4 µM 0.118056180046436 0.448175042403151 no 1481 0.453011571914192 2132 2883011 SGTC_2852 9023854 51.95 µM 0.117835120596106 0.448268218905404 no 1482 0.453099150590567 2145 19798528 SGTC_3293 9120939 62.045 µM 0.117014881238654 0.448613974488103 no 1483 0.453424130486168 2142 934087 SGTC_2523 spermine 47.74 µM 0.116963097981971 0.448635804002393 no 1484 0.453444648128586 2178 1103 A DNA binding polyamine. SGTC_1936 st074407 74.3 µM 0.11381645171733 0.449962579285328 no 1485 0.454691648378905 2149 809813 SGTC_488 nitrendipine 139 µM 0.113663435649772 0.450027112500632 no 1486 0.454752299372095 2227 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2780 5215298 71.43 µM 0.113581973115174 0.450061469165686 no 1487 0.454784589115024 2238 2834131 SGTC_3004 9076122 71.4286 µM 0.11284052730045 0.450374189666318 no 1488 0.455078493688396 2192 44782551 SGTC_572 0960-0087 17.7 µM 0.112742337676992 0.450415605537609 no 1489 0.455117417300254 2157 6796365 SGTC_2030 5175110 200 µM 0.112705842973669 0.450430998950879 no 1490 0.45513188437329 2153 2831986 SGTC_2033 5192550 145 µM 0.112495777652329 0.450519605649907 no 1491 0.455215158719252 2107 182073 SGTC_2320 7373003 200 µM 0.11234296300622 0.450584065251524 no 1492 0.455275738920769 2087 5415828 SGTC_1673 st016611 27.3 µM 0.110976867684819 0.451160363280381 no 1493 0.455817345159583 2165 5226799 SGTC_1852 st056254 31.4 µM 0.109559392766721 0.451758445024582 no 1494 0.456379408300971 2116 442583 SGTC_1999 st074831 12.5 µM 0.108636684191264 0.452147826647845 no 1495 0.45674533157922 2076 17112523 SGTC_849 0386-0493 241 µM 0.108554751562601 0.452182404323908 no 1496 0.456777825800262 2101 726119 SGTC_2129 girgensonine 121.053 µM 0.108382490797907 0.452255103978612 no 1497 0.456846144816307 2136 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_782 0083-0095 30.5 µM 0.108317096365816 0.452282702978751 no 1498 0.456872080732828 2248 3591729 An indicator and reagent. SGTC_1861 st057647 17.4 µM 0.107939584396012 0.452442032253006 no 1499 0.457021808366522 2206 688668 SGTC_2972 9093619 59.92 µM 0.1079347750712 0.452444062082428 no 1500 0.457023715865507 2004 25236256 SGTC_892 0929-0076 29 µM 0.106598988145142 0.453007893847547 no 1501 0.457553560677576 2095 5751038 SGTC_265 mycophenolic acid 32.932 µM 0.105616018106332 0.453422863217609 no 1502 0.457943507612755 2190 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2436 5633522 8.09 µM 0.105223346690135 0.453588647121431 no 1503 0.458099292788052 2228 5724242 SGTC_1508 1080-0625 72.9 µM 0.103903666897104 0.454145868418341 no 1504 0.45862289854906 2220 767111 SGTC_2506 ethyl hematommate 54.16 µM 0.103039293561971 0.45451089021145 no 1505 0.458965892578012 2030 3940691 An allergen. SGTC_3024 9090631 49.47 µM 0.102322928941939 0.454813437577113 no 1506 0.459250178080466 2245 25236383 SGTC_1685 st024049 53.0905 µM 0.101709832733639 0.455072391684999 no 1507 0.459493498616048 2145 1941139 SGTC_624 k048-0052 28 µM 0.101537413163928 0.455145220169279 no 1508 0.459561929801638 2117 6835531 SGTC_2836 9010338 19.48 µM 0.099289690359142 0.456094775218328 no 1509 0.460454131934851 2084 2994051 SGTC_2198 6589944 200 µM 0.0992083559795466 0.456129139826349 no 1510 0.460486420239601 2186 5290268 SGTC_1385 3091-4834 14.1 µM 0.0988552755871581 0.456278323707918 no 1511 0.460626589904762 2167 4072814 SGTC_3056 9094900 49.47 µM 0.0987294258730975 0.456331499346391 no 1512 0.460676552266233 2144 25236784 SGTC_452 diindolylmethane 8 µM 0.0980501929163488 0.456618511061815 no 1513 0.460946218582006 2180 3071 Inhibits expression of several cancer promoting factors. SGTC_1191 1487-1166 10.6 µM 0.0980490009933988 0.456619014732005 no 1514 0.460946691810247 2171 3955771 SGTC_2153 5569715 200 µM 0.0977889838941601 0.456728891671528 no 1515 0.461049927517593 2232 2054701 SGTC_908 3448-7491 47.7 µM 0.0977441226562794 0.456747849280894 no 1516 0.461067739233544 2172 1203031 SGTC_807 1315-0151 48 µM 0.0974795414527098 0.456859658876525 no 1517 0.461172790201452 2257 4011080 SGTC_2091 4-phenylthiadiazole 200 µM 0.0968950284343201 0.45710668082404 no 1518 0.461404878482693 2164 270010 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.0962499765712015 0.457379306420089 no 1519 0.461661019731891 2180 641818 YHR062C RPP1 SGTC_1179 1021-1431 9.29 µM 0.0957080183594637 0.457608375885863 no 1520 0.461876236204092 2167 2840958 SGTC_855 0428-0020 25 µM 0.0936889958651736 0.458461879438116 no 1521 0.46267810592699 2115 6812414 SGTC_594 1487-1584 10.8 µM 0.0934244575451246 0.458573722283741 no 1522 0.462783180587659 2175 5013332 SGTC_2451 5856223 45.7 µM 0.0929505106492065 0.458774108139086 no 1523 0.462971438855542 2169 2179896 SGTC_1359 1582-0056 520 nM 0.0924788513826918 0.458973537180053 no 1524 0.463158796679113 2192 3661189 SGTC_3170 9103054 49.47 µM 0.092241289017764 0.459073988254972 no 1525 0.463253166983487 2157 16432970 SGTC_210 3551-0445 56.827 µM 0.0921714143009145 0.459103534638024 no 1526 0.463280924712937 2208 2865180 YOR207C RET1 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.0919984657582532 0.459176666551587 no 1527 0.463349629285571 2242 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1872 amphotericin b 148 nM 0.0912227466751738 0.459504699116359 no 1528 0.463657800536711 2218 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.0907916259444851 0.45968702142773 no 1529 0.463829082049006 2252 5024745 SGTC_3348 9149464 3.537 µM 0.088212108347254 0.460778083318192 no 1530 0.464854046882579 2267 1951442 SGTC_574 1315-0397 40 µM 0.0873981899444692 0.46112240912103 no 1531 0.465177504044975 2243 6794277 SGTC_3248 9135562 49.47 µM 0.0872737891116842 0.461175039104348 no 1532 0.46522694388381 2217 17650701 SGTC_754 3474-0146 171 µM 0.0863361063407553 0.461571764282244 no 1533 0.465599618454975 2158 24762078 SGTC_1527 coumarin 137 µM 0.0857187699132994 0.461832974693903 no 1534 0.465844990406696 2189 323 A hepatotoxic, DNA x-linker. SGTC_123 0083-0120 66.675 µM 0.0847393119897849 0.462247441463753 no 1535 0.46623432095126 2143 16001701 SGTC_2121 5257820 149.641 µM 0.0834480486813672 0.462793914173065 no 1536 0.46674764219293 2267 791256 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.0822737231598757 0.463290958901586 no 1537 0.467214524722814 2242 91467 include heat shock SGTC_335 4077-0256 27.6 µM 0.0806425136826529 0.463981479151442 no 1538 0.467863127628207 2251 3121989 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.076600695761259 0.465692916387852 no 1539 0.469470602722013 2255 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_382 3229-0966 23.2 µM 0.0765168384519546 0.4657284311316 no 1540 0.469503959050021 2258 5722370 SGTC_2991 9074669 71.4286 µM 0.075658445996541 0.466091987993486 no 1541 0.469845418241421 2251 17333109 SGTC_2775 cyproheptadine 69.59 µM 0.0755380281545916 0.466142991099595 no 1542 0.469893320929927 2288 2913 A selective serotonin reuptake inhibitor. SGTC_877 0771-0151 33.1 µM 0.0753758981501161 0.466211662315062 no 1543 0.46995781756798 2170 6166523 SGTC_1101 ebselen 5.29 µM 0.0719541098229764 0.467661214443352 no 1544 0.471319214096722 2292 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2179 6298986 200 µM 0.0697787491758827 0.468582973962485 no 1545 0.472184880821158 2285 738374 SGTC_1799 st045822 46.1415 µM 0.068963581182682 0.468928426481374 no 1546 0.472509304229521 2288 3674992 SGTC_2226 7298446 200 µM 0.068844714148131 0.468978802005208 no 1547 0.472556612876355 2297 3283010 SGTC_1342 1486-1464 234 µM 0.0676126371943754 0.469500981949772 no 1548 0.473046997697598 2293 3253938 SGTC_3029 9088683 49.47 µM 0.0669063041058252 0.469800364380557 no 1549 0.473328147167972 2227 25236615 SGTC_1496 4469-0713 57.4 µM 0.06623236541999 0.470086032218478 no 1550 0.473596414729394 2290 746691 SGTC_2255 7941087 197.44 µM 0.065012544656492 0.470603126558629 no 1551 0.47408200609734 2305 935561 SGTC_829 1635-0120 117 µM 0.0649425333994364 0.470632806550032 no 1552 0.474109877647764 2281 285054 SGTC_3320 9137005 35.139 µM 0.0647961359990676 0.470694869576242 no 1553 0.474168159006497 2150 4908713 SGTC_851 0394-0702 453 µM 0.0645099334917896 0.470816202977358 no 1554 0.474282098902761 2301 762646 SGTC_1835 st008666 49.2 µM 0.0626266277234205 0.471614683346574 no 1555 0.475031912587679 2176 690455 SGTC_879 0831-1030 162 µM 0.0623666070236937 0.471724935461718 no 1556 0.475135443453897 2290 1549252 SGTC_3060 1327-0027 12.5 µM 0.0623146851029378 0.471746951282563 no 1557 0.475156117091748 2296 16000455 YPR107C YTH1 SGTC_2035 5154463 94.595 µM 0.0623058662453924 0.471750690644096 no 1558 0.475159628483653 2285 2769623 SGTC_1473 k844-0725 134 µM 0.0619610528816736 0.471896899947155 no 1559 0.475296923837721 2298 54682906 SGTC_1430 4049-0248 69.1 µM 0.0612900700778451 0.472181423911346 no 1560 0.47556409943292 2283 22774488 SGTC_1060 3448-7350 82 µM 0.0608925805529086 0.472349982321321 no 1561 0.475722379171773 2289 570178 SGTC_2254 7938975 95.19 µM 0.0603740101608192 0.472569893419672 no 1562 0.475928878887723 2285 2969277 SGTC_2675 theaflavin digallate 100 µM 0.0601694220220192 0.472656655791216 no 1563 0.476010349633182 2294 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2638 epoxomicin 18 µM 0.0600258235587314 0.472717554247398 no 1564 0.47606753377157 2300 9915668 A protesome inhibitor. SGTC_2095 5432005 200 µM 0.0595019155256252 0.472939743013816 no 1565 0.476276169906798 2289 783734 SGTC_2044 5102272 200 µM 0.0592219488522139 0.473058479999433 no 1566 0.476387663833079 2245 592666 SGTC_1509 1326-1131 80 µM 0.0584052227463849 0.473404876280607 no 1567 0.476712927362992 2288 768313 SGTC_1920 st075728 45.7 µM 0.058347933148304 0.473429175152116 no 1568 0.476735743695717 2305 3400306 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.0581029498978077 0.473533083724659 no 1569 0.476833312343119 2231 5282362 SGTC_1488 4013-0813 75.9 µM 0.0579969762327776 0.473578032548854 no 1570 0.476875518545553 2252 2910057 SGTC_1713 st033146 12.748 µM 0.0571361159043169 0.473943179637622 no 1571 0.477218383535216 2301 674619 SGTC_687 k029-0044 34.9 µM 0.0558014032278673 0.474509361629126 no 1572 0.477750008536739 2302 5829338 SGTC_678 1218-2179 85.9 µM 0.0555298599018734 0.474624556012095 no 1573 0.477858170940827 2321 6820081 YOR116C RPO31 SGTC_2885 9057732 51.95 µM 0.0550780696426514 0.474816219626878 no 1574 0.478038133754335 2243 6471414 SGTC_2507 purpurin 79.67 µM 0.0546939779312997 0.474979167977357 no 1575 0.478191133548885 2317 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_3044 9093193 49.47 µM 0.0533997692792443 0.475528258031536 no 1576 0.478706694520331 2254 25236277 SGTC_1760 st045453 10.4495 µM 0.0523984520935671 0.475953115840042 no 1577 0.479105603737501 2309 3323419 YIL048W NEO1 SGTC_2531 methyl deoxycholate 70.07 µM 0.0512593026621751 0.476436488940498 no 1578 0.479559448608901 2275 16667744 Haematoxylin. SGTC_2360 9040895 200 µM 0.0511990522149766 0.47646205586933 no 1579 0.479583453539409 2258 4914414 SGTC_417 st075190 100 µM 0.0509045731359864 0.476587017755705 no 1580 0.479700780700462 2320 222757 SGTC_881 0833-0569 170 µM 0.0507160686026967 0.476667010664915 no 1581 0.479775886116725 2244 5418700 SGTC_3075 9116269 49.47 µM 0.0504526835329273 0.476778781105183 no 1582 0.479880827210318 2263 17015205 YNL244C SUI1 SGTC_57 miconazole 162.5 nM 0.050327517644788 0.476831897309686 no 1583 0.479930697820135 2324 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3201 9113999 49.47 µM 0.049935149979521 0.476998407649032 no 1584 0.48008703329949 2292 16649224 SGTC_1545 lovastatin 49.4 µM 0.0498528348204088 0.477033340510825 no 1585 0.480119831447325 2283 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0495455822205984 0.477163733756226 no 1586 0.480242256210993 2276 688803 SGTC_375 3970-0961 9.27 µM 0.0491699073251324 0.477323167685243 no 1587 0.480391946361906 2273 2898222 SGTC_542 3381-0244 89.3 µM 0.0486175557912219 0.47755758858984 no 1588 0.48061203950534 2323 1112843 SGTC_1160 4092-0570 10.5 µM 0.0483852447703429 0.47765618493707 no 1589 0.48070460924963 2293 4994975 SGTC_2588 indole-3-carbinol 100 µM 0.0469844372784674 0.478250737815302 no 1590 0.48126281554132 2319 3712 Induces cell cycle arrest. SGTC_1017 4239-0030 168 µM 0.0463049056114085 0.478539172914621 no 1591 0.481533614696384 2237 1149593 SGTC_1453 4237-0541 195 µM 0.0452994959968334 0.478965951263528 no 1592 0.481934294581938 2322 739892 SGTC_2145 5634607 200 µM 0.0451702988296082 0.479020794902812 no 1593 0.48198578408865 2306 308662 SGTC_2298 7976326 193.81 µM 0.0446215416166292 0.479253744382889 no 1594 0.482204486016159 2294 2235818 SGTC_3259 9138485 49.47 µM 0.044244470028563 0.47941381678851 no 1595 0.482354767391583 2328 17646153 SGTC_3303 9125618 40.5795 µM 0.0424274450888382 0.480185216546982 no 1596 0.483078975012829 2276 22695467 SGTC_27 0485-0001 32.618 µM 0.0413659806644666 0.480635885173436 no 1597 0.483502066534423 2328 2054479 SGTC_780 0109-0199 192 µM 0.0409356442669344 0.480818601266451 no 1598 0.483673600618372 2332 610414 SGTC_1106 tegaserod maleate 11.7 µM 0.040284770819014 0.481094962605688 no 1599 0.483933047524646 2241 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_117 lucigenin 22.078 µM 0.0401061777243454 0.481170794957758 no 1600 0.484004238327125 2247 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2021 4019055 173 µM 0.0396386025937322 0.481369335092086 no 1601 0.484190625595454 2318 44827708 YER133W GLC7 SGTC_1521 st012942 49.4 µM 0.039606273887861 0.481383062566693 no 1602 0.4842035127631 2323 24207259 SGTC_2367 9070478 135.38 µM 0.0387019302427582 0.481767075516734 no 1603 0.484564017226384 2326 572802 SGTC_1133 3473-0247 50 µM 0.0383847243684513 0.481901775202149 no 1604 0.484690470097375 2240 711311 SGTC_895 0964-0006 13.7 µM 0.0381293950528199 0.482010200857513 no 1605 0.484792257241303 2322 6738897 SGTC_1261 0712-0010 12.7 µM 0.0376952257457882 0.482194574009097 no 1606 0.48496534129806 2319 2840123 SGTC_2431 5490079 200 µM 0.0375340067305824 0.482263037807251 no 1607 0.485029612895839 2323 5722345 SGTC_2779 methotrexate 400 µM 0.0350859293492948 0.483302709517013 no 1608 0.486005610628833 2344 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_3033 9090887 49.47 µM 0.0350431779360186 0.483320866604325 no 1609 0.486022655493388 2333 19325384 SGTC_334 1502-1024 68.5 µM 0.0341572729409132 0.483697129833052 no 1610 0.486375868948253 2265 3296216 SGTC_2238 6671620 73.2395 µM 0.0341249982011694 0.483710837897096 no 1611 0.486388737204609 2347 729941 SGTC_1893 st059353 36.1 µM 0.0336062956501286 0.483931149284016 no 1612 0.486595550951358 2205 3112488 SGTC_1736 st036774 51 µM 0.0332450144431801 0.484084601140282 no 1613 0.486739600805052 2352 1272247 SGTC_405 ebelactone b 50 µM 0.0324879277893041 0.484406176419315 no 1614 0.487041471588814 2298 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1757 st041620 31.8375 µM 0.0322236465004787 0.484518433246144 no 1615 0.487146849394248 2301 5289815 SGTC_3158 9100007 49.47 µM 0.0298958165722225 0.485507260514188 no 1616 0.488075071125773 2337 19297233 SGTC_1834 st055981 52.8 µM 0.0297584345931892 0.485565621164716 no 1617 0.488129854231212 2348 471719 YDL150W RPC53 SGTC_1445 4239-0156 97.7 µM 0.029326102503784 0.485749280320799 no 1618 0.488302254532287 2335 4008346 SGTC_709 3807-1509 243 µM 0.0284800703728503 0.486108692255547 no 1619 0.488639631559973 2348 1886677 YPL242C IQG1 SGTC_2275 7947463 200 µM 0.0281821433474751 0.486235260514905 no 1620 0.488758439556146 2361 1225414 SGTC_3050 9093513 49.47 µM 0.0279665334266474 0.486326858886094 no 1621 0.488844421578635 2360 25236664 SGTC_133 0724-0033 378.92 µM 0.0278585803683623 0.48637272125998 no 1622 0.488887471844131 2353 280309 SGTC_2897 9048598 12.99 µM 0.0275939820100684 0.486485132998815 no 1623 0.488992990749822 2342 6467404 SGTC_1937 st074714 47.2 µM 0.0275070215378557 0.486522077445891 no 1624 0.489027669795183 2353 17250970 SGTC_1844 rapamycin 4 nM 0.0264534645422326 0.486969681635916 no 1625 0.489447825255671 2344 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_51 1013-0126 23.419 µM 0.0264349788433651 0.486977535442046 no 1626 0.489455197404421 2366 1627850 SGTC_1380 2291-0730 164 µM 0.0262959001658551 0.487036624360861 no 1627 0.489510662487888 2326 2999191 SGTC_1000 4048-0884 8.67 µM 0.0262808890826639 0.487043001981512 no 1628 0.48951664897472 2328 13040088 SGTC_1367 1812-0510 76.9 µM 0.0255871012247151 0.487337768827327 no 1629 0.489793337217294 2338 1142582 YDR527W RBA50 SGTC_3137 9097352 49.47 µM 0.0248216392571334 0.487662995582636 no 1630 0.490098615371807 2332 44120435 SGTC_2684 capsaicin 100 µM 0.0241367355411628 0.487954001995985 no 1631 0.490371770563036 2334 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2591 skatole 100 µM 0.0223435855812349 0.488715917372407 no 1632 0.491086940641792 2340 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_743 1275-0778 158 µM 0.0220685401359071 0.488832788808358 no 1633 0.491196640848193 2359 2849257 YMR203W TOM40 SGTC_1620 st003704 16.5 µM 0.02104101622279 0.489269409403488 no 1634 0.491606468347513 2356 2834414 SGTC_2072 5231554 129 µM 0.0210303348738891 0.489273948244073 no 1635 0.491610728646506 2370 789545 SGTC_3183 9108214 49.47 µM 0.0191205633853865 0.49008549189087 no 1636 0.492372463609367 2371 4974831 SGTC_3155 9099265 49.47 µM 0.0188057337181294 0.49021928052252 no 1637 0.492498039893533 2368 25236499 SGTC_1382 3002-2117 298 µM 0.0178226530855205 0.490637053161798 no 1638 0.492890166540086 2367 1497314 SGTC_2481 5478948 45.16 µM 0.0170650887208294 0.490958996821363 no 1639 0.493192345009827 2361 77792 SGTC_3126 9127922 49.47 µM 0.0169774273120852 0.490996250851656 no 1640 0.493227311786413 2344 45595682 SGTC_646 4092-0839 27.3 µM 0.0165705172019331 0.491169179070456 no 1641 0.493389622596566 2360 877796 SGTC_1682 st012968 530 nM 0.0162511720179008 0.491304895205701 no 1642 0.493517005737676 2367 24207270 SGTC_997 3996-0078 137 µM 0.0158678662715454 0.491467794792566 no 1643 0.4936699028873 2367 735687 SGTC_1086 cerivastatin 2.18 µM 0.0154804091593491 0.491632460098055 no 1644 0.493824456923755 2383 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2496 diffractaic acid 79.83 µM 0.0152633594307168 0.491724704635293 no 1645 0.493911037007469 2373 94870 An apoptosis inducer which activates caspases. SGTC_2981 9013952 38.96 µM 0.014779215722906 0.491930463735187 no 1646 0.494104160611074 2346 2996344 SGTC_543 3844-1095 191 µM 0.0129152832496369 0.492722646989893 no 1647 0.494847690686856 2373 4230703 SGTC_2798 7813637 45.45 µM 0.0127512674747967 0.49279235616545 no 1648 0.494913118126079 2375 956368 SGTC_522 1273-0010 11.6 µM 0.0125026248047363 0.492898033465636 no 1649 0.495012304292197 2357 5705015 SGTC_2413 inermin 26.06 µM 0.0121248095429157 0.493058612232964 no 1650 0.495163019346706 2371 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_3089 9117425 49.47 µM 0.0097700592101645 0.494059450833532 no 1651 0.496102372306535 2361 9401657 SGTC_2311 7694451 200 µM 0.00962028644815591 0.494123110022603 no 1652 0.496162120185588 2373 2163142 SGTC_2582 agaric acid 100 µM 0.00913402625630701 0.494329790345159 no 1653 0.496356101404807 2385 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_3226 9131256 49.47 µM 0.0089591998512249 0.494404099039749 no 1654 0.496425844195461 2391 17178073 SGTC_1141 3253-0389 52.6 µM 0.00880467470043152 0.494469778995293 no 1655 0.49648748837987 2374 5402031 SGTC_2293 7624732 200 µM 0.00720667182299007 0.495149008659024 no 1656 0.497124978795094 2390 894453 SGTC_2662 daunorubicin 22.37 µM 0.00454777920027284 0.496279198742141 no 1657 0.498185704849048 2361 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1375 2910-0797 186 µM 0.00332370926342417 0.496799513042567 no 1658 0.498674034288392 2396 742508 SGTC_2231 micatex 6.853 µM 0.00320730472737539 0.496848993310765 no 1659 0.498720472731827 2401 20737 An antifungal of unknown mechanism. SGTC_412 gemfibrozil 100 µM 0.00270043984635576 0.497064447757189 no 1660 0.498922681678976 2398 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_361 000s-0510 1.45 µM 0.00241603923099152 0.497185339086531 no 1661 0.499036140737363 2398 660 SGTC_2166 5933061 31.504 µM 0.00105710825804867 0.497762988791989 no 1662 0.499578274899448 2399 2877375 SGTC_750 4073-0104 132 µM 0.000649195165426613 0.497936384057202 no 1663 0.499741008618471 2403 22330957 SGTC_588 3970-1144 52.9 µM 0.000347961315319606 0.498064432475117 no 1664 0.499861183522176 2400 1888707 SGTC_189 3970-0742 2.116 µM 0 0.498212344040894 no 1665 0.5 2406 2891807 SGTC_362 0310-0100 9.03 µM 0 0.498212344040894 no 1666 0.5 2405 790235 SGTC_1254 0550-0035 264 µM 0 0.498212344040894 no 1667 0.5 2406 15121435 SGTC_2909 7941780 10.49 µM -0.000632502586196041 0.498481209164131 no 1668 0.499747667992728 2407 1243215 SGTC_1054 3429-0080 167 µM -0.000900298391610767 0.498595044411207 no 1669 0.499640832955129 2409 1162877 SGTC_2468 5987765 72.9 µM -0.00106164966198946 0.498663632030229 no 1670 0.49957646314242 2408 26772094 SGTC_3111 9122088 49.47 µM -0.00128413167265559 0.498758205328203 no 1671 0.49948770572297 2411 16876704 SGTC_2819 7996655 46.38 µM -0.0015798654727305 0.498883916816276 no 1672 0.499369725127773 2411 6456960 SGTC_3278 9139605 49.47 µM -0.00215531640885976 0.499128531682999 no 1673 0.499140153822583 2412 7958859 SGTC_364 0083-0097 67.7 µM -0.00245546583203674 0.499256120474161 no 1674 0.499020411845893 2411 5207356 SGTC_2358 9037157 4 µM -0.00318373912200252 0.499565698266809 no 1675 0.498729874000173 2416 2388925 SGTC_859 0439-0102 54.6 µM -0.00329893142385583 0.499614664774251 no 1676 0.498683919162019 2412 610143 SGTC_1729 st035615 45.989 µM -0.00371686227740534 0.499792320910211 no 1677 0.498517189901301 2434 17385451 SGTC_1448 4255-0083 152 µM -0.00379065434597896 0.499823688816801 no 1678 0.498487751332601 2413 5399660 SGTC_2060 5238662 140 µM -0.00462018792019829 0.499823688816801 no 1679 0.498156818252703 2417 790130 SGTC_1469 k284-2957 126 µM -0.0046432816564832 0.499813872014183 no 1680 0.49814760528371 2425 23884841 SGTC_1388 3346-4487 254 µM -0.00473502419525123 0.499774873631396 no 1681 0.498111005708478 2421 3345614 SGTC_1221 2958-7315 257 µM -0.00475613990541098 0.499765897658723 no 1682 0.49810258185377 2428 4562705 SGTC_2000 st075254 36.4 µM -0.00518072298431562 0.499585413771409 no 1683 0.497933199803962 2413 17234175 SGTC_1329 1447-1697 50.6 µM -0.00568271043349271 0.499372026561687 no 1684 0.497732938742584 2449 2840515 SGTC_2803 7707263 71.43 µM -0.00586811997779265 0.499293211833948 no 1685 0.497658972269881 2416 2199229 SGTC_1975 st070967 30.8 µM -0.00609620088024263 0.499196258210436 no 1686 0.497567982782839 2420 261391 SGTC_1392 3455-1037 33.9 µM -0.00631234928405366 0.499104376949142 no 1687 0.497481753705511 2419 981132 SGTC_469 w7 172 µM -0.00697743588502998 0.498821659493419 no 1688 0.497216428402873 2423 45115570 A P450 inhibitor. SGTC_164 4100-3994 89.624 µM -0.00841651952639458 0.498209930746322 no 1689 0.496642334148755 2419 4615967 SGTC_1400 3771-8998 51.5 µM -0.00964451179389954 0.497687936443675 no 1690 0.496152456119256 2422 670767 SGTC_2625 euphol 100 µM -0.00970929983380447 0.497660396480082 no 1691 0.496126610641024 2425 6708538 A triterpene alcohol. SGTC_948 3448-0295 75.3 µM -0.0107857711340227 0.497202814057883 no 1692 0.495697183294562 2431 678569 SGTC_3270 9137563 49.47 µM -0.0110575698633203 0.497087279421686 no 1693 0.495588757756868 2499 17015724 SGTC_1818 st052136 56.3 µM -0.0132704903294118 0.496146633903367 no 1694 0.494705995710639 2446 674169 SGTC_2874 9043904 71.43 µM -0.0144233796113743 0.495656583717817 no 1695 0.494246103548335 2462 4463428 SGTC_427 1354-0053 47.3 µM -0.0152309239125375 0.495313330647978 no 1696 0.493923975403041 2521 6813657 SGTC_920 mycophenolic acid 780.421 nM -0.0155799726740701 0.495164965780009 no 1697 0.493784741617857 2440 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3106 9121286 49.47 µM -0.0157024049137899 0.495112925520452 no 1698 0.493735904195304 2521 15943471 SGTC_146 3448-8650 53.125 µM -0.0165156839142767 0.494767240538042 no 1699 0.493411494920233 2468 2891488 YIL048W NEO1 SGTC_73 0327-0325 16.231 µM -0.0174685864309382 0.494362213470471 no 1700 0.493031396708959 2441 53298 SGTC_2567 aureobasidin a 60 nM -0.0177884168191432 0.494226272237861 no 1701 0.492903822669345 2480 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2002 4023503 131 µM -0.0180345024095789 0.494121676070605 no 1702 0.492805664469809 2427 4736863 YCR052W RSC6 SGTC_2401 5128683 200 µM -0.0185596477527095 0.493898469765648 no 1703 0.492596196857513 2461 708373 SGTC_1098 clofazimine 15.1 µM -0.0186804637403861 0.493847118744583 no 1704 0.492548006606569 2498 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1774 st048371 48.465 µM -0.0188716747576862 0.493765847582132 no 1705 0.492471737892507 2433 4242727 SGTC_2476 5806916 10.51 µM -0.0191468274187663 0.493648898831267 no 1706 0.492361987693781 2453 2870194 SGTC_352 k048-0007 5.11 µM -0.0194066768030205 0.49353845496738 no 1707 0.492258342046954 2444 6811911 SGTC_3316 9136639 10.545 µM -0.0201095283935996 0.49323972424502 no 1708 0.491977999562151 2493 4903665 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.0211866287716404 0.49278193519394 no 1709 0.491548390292123 2464 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_49 0717-0965 32.132 µM -0.0222782821458402 0.49231797053321 no 1710 0.4911129864599 2616 5889349 YGL099W LSG1 SGTC_1608 st001473 40.5 µM -0.0225717390387915 0.492193249880425 no 1711 0.490995943531285 2452 7292267 SGTC_747 3448-8087 38.7 µM -0.0227876161377483 0.492101501516106 no 1712 0.49090984317578 2469 5168703 SGTC_2416 tofa 880 nM -0.0236084268763969 0.491752658537522 no 1713 0.490582475175215 2475 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2766 oltipraz 83.91 µM -0.0249837133668858 0.491168178708294 no 1714 0.49003397720251 2463 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_179 1273-0063 6.77 µM -0.0262747551990932 0.490619519054293 no 1715 0.489519095195487 2459 3108139 SGTC_2488 5268135 45.7 µM -0.0266902407046222 0.490442952099787 no 1716 0.489353398575218 2477 1270356 YLR208W SEC13 SGTC_87 0100-0052 35.5 µM -0.0268736392376288 0.490365014666786 no 1717 0.489280259381404 2454 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_589 1227-0070 34.1 µM -0.0271944446220188 0.490228685410538 no 1718 0.489152323309244 2481 2841384 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.0294934424598213 0.489251739081611 no 1719 0.48823552441354 2479 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1137 ixabepilone 100 µM -0.0296848995257281 0.489170383295464 no 1720 0.488159177524079 2458 154225 A novel microtubule stabilizer. SGTC_2102 5377816 72.7585 µM -0.0314261211500369 0.488430507683013 no 1721 0.48746485488535 2494 1379702 SGTC_48 0382-0018 55 µM -0.0316699002537458 0.488326924784541 no 1722 0.487367649479232 2455 762596 SGTC_2653 dihydrofissinolide 100 µM -0.0317374102341044 0.488298239612313 no 1723 0.487340730425586 2489 6857746 SGTC_2328 6201408 200 µM -0.0320462769738889 0.488167002078118 no 1724 0.487217573071531 2492 2890418 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.0324273878056426 0.488005069783422 no 1725 0.487065610829259 2500 521171 SGTC_1847 st056231 15 µM -0.0325651156743052 0.487946550310592 no 1726 0.487010694363029 2466 5393180 SGTC_2438 5259590 200 µM -0.0332990494823138 0.487634712096402 no 1727 0.486718055872045 2503 1201127 SGTC_2711 st079103 59.1 µM -0.0351346224050724 0.486854836338209 no 1728 0.485986196879782 2507 54693780 SGTC_2427 5545055 42.75 µM -0.0357394947163589 0.486597856459023 no 1729 0.485745039212892 2474 5372858 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.0357858390820975 0.48657816729278 no 1730 0.485726562305411 2468 16623 A steroid. SGTC_2247 cerulenin 830 nM -0.036948745047922 0.486084123490362 no 1731 0.485262936665998 2557 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2649 anisomycin 9.56 µM -0.0370466432105662 0.486042533834133 no 1732 0.485223907670922 2487 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1647 st011722 22.4 µM -0.0374029416773395 0.485891170370893 no 1733 0.485081863597119 2500 2854783 SGTC_1789 tunicamycin 25 nM -0.0379259217715657 0.485669000556118 no 1734 0.484873372664158 2540 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2536 dehydroabietamide 32.04 µM -0.0380023344476849 0.485636539672115 no 1735 0.484842910377081 2506 3983547 SGTC_1922 5578187 25 µM -0.0388842094367825 0.485261917126553 no 1736 0.484491353045971 2481 1350412 SGTC_650 1328-0195 38 µM -0.0390192460086711 0.485204554417011 no 1737 0.484437522100733 2469 2780821 SGTC_983 1491-0821 12.2 µM -0.0391172363113376 0.485162928927605 no 1738 0.484398459448523 2501 46495113 SGTC_1201 1889-3372 45.9 µM -0.039313965532876 0.485079360431254 no 1739 0.484320036169721 2524 5392199 SGTC_3179 9107801 49.47 µM -0.0393208137078682 0.485076451410598 no 1740 0.484317306254018 2485 4818259 SGTC_228 caffeine 993.056 µM -0.0393747321177418 0.485053547559844 no 1741 0.484295812565844 2473 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3189 9110682 49.47 µM -0.0410349172421494 0.484348346658094 no 1742 0.483634029680732 2504 17122418 SGTC_2242 6630449 61.2675 µM -0.0411986519105878 0.484278799298136 no 1743 0.483568764190712 2640 691249 YDR170C SEC7 SGTC_2796 7949634 45.45 µM -0.0412214207730302 0.484269128114305 no 1744 0.483559688438606 2477 2971588 SGTC_2285 7945142 200 µM -0.0417337148480074 0.484051531199354 no 1745 0.483355488401609 2522 2970608 SGTC_3255 9139072 49.47 µM -0.0418536687961805 0.484000581442197 no 1746 0.483307675475972 2534 17646060 SGTC_1061 3448-9325 110 µM -0.0421077104788361 0.483892679546038 no 1747 0.483206416775442 2473 723482 SGTC_605 1315-0399 119 µM -0.0441055294551347 0.483044165833738 no 1748 0.482410142603933 2543 24020461 SGTC_1516 st013856 110 µM -0.0451801869508998 0.482587768800584 no 1749 0.481981843322208 2620 5281404 A mutagen and neurotoxin. SGTC_554 4483-2211 187 µM -0.0466414779641915 0.481967208833501 no 1750 0.481399486675315 2549 747107 SGTC_2612 dictamnine 15.46 µM -0.0468236724942953 0.481889840123717 no 1751 0.481326880900497 2535 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_622 1348-1566 26.3 µM -0.0476272224273192 0.481548621692562 no 1752 0.481006668141685 2537 7340407 SGTC_1884 5633444 25 µM -0.0477151973891851 0.481511264932039 no 1753 0.480971611066808 2550 5724239 SGTC_438 sphingosine 6.67 µM -0.0480876378800354 0.481353117530032 no 1754 0.480823199175583 2504 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_520 3584-0023 682 µM -0.0520230714740431 0.479682219704163 no 1755 0.479255154962419 2572 1340790 SGTC_3072 9116419 49.47 µM -0.0527550293674802 0.479371485108312 no 1756 0.478963546468636 2532 17170162 SGTC_2713 st079149 53.4 µM -0.0537688928795505 0.478941095212883 no 1757 0.478559646769591 2540 3103253 SGTC_2624 nerol 100 µM -0.0539652546366332 0.478857741533388 no 1758 0.4784814233339 2491 637566 A natural product oil. SGTC_2113 5491891 107.031 µM -0.0543645988283578 0.478688226616744 no 1759 0.478322341583832 2513 789979 SGTC_1726 st035556 14.5795 µM -0.0544421715893795 0.478655298725961 no 1760 0.478291440293227 2729 5919439 SGTC_1933 st074711 15.9 µM -0.0547219385440771 0.478536545163448 no 1761 0.478179995558524 2489 17250958 SGTC_316 k060-0003 58.6 µM -0.0560035946153812 0.477992541084921 no 1762 0.477669471784307 2601 6152314 SGTC_1055 3448-0672 86 µM -0.0568489846140936 0.477633734276345 no 1763 0.477332746461601 2594 748378 SGTC_298 1391-0729 10 µM -0.0573454107048417 0.477423045795386 no 1764 0.477135023666807 2507 3237558 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.0583272282078382 0.477006370705519 no 1765 0.476743989728186 2573 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_25 0118-0223 35.662 µM -0.0584377017132073 0.476959488244002 no 1766 0.476699992223001 2515 5333628 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.0589401796687248 0.476746251977748 no 1767 0.476499877457438 2530 2374 Ca(2+)-ATPase inhibitor. SGTC_2820 7989630 71.43 µM -0.0594791994556312 0.476517515880512 no 1768 0.476285216285252 2515 2984098 SGTC_2183 6420625 130.508 µM -0.0598050746224623 0.476379232657145 no 1769 0.476155441924701 2508 2897619 SGTC_1289 0976-0073 69.1 µM -0.060058942681587 0.47627150719964 no 1770 0.476054344948046 2599 3391136 SGTC_1271 0832-2808 169 µM -0.0607518550433133 0.475977488114184 no 1771 0.475778416780372 2554 3663794 SGTC_2174 5790901 200 µM -0.0607739752125621 0.475968102218355 no 1772 0.475769608385505 2550 786020 SGTC_2420 aureobasidin a 50 nM -0.0608856268714686 0.475920727068385 no 1773 0.475725148151571 2711 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1562 morin hydrate 59.1 µM -0.0621048083710589 0.475403435900348 no 1774 0.475239683933026 2617 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_106 0092-0003 11.579 µM -0.0633679288147598 0.474867545445602 no 1775 0.474736762502786 2618 1072148 SGTC_1194 1488-0194 225 µM -0.0634396864797338 0.474837102952554 no 1776 0.474708192819718 2512 1391452 SGTC_1954 st077032 68.9 µM -0.0638682260904059 0.474655302245753 no 1777 0.474537576256193 2600 698907 SGTC_784 4579-0127 173 µM -0.063942424266379 0.474623825455115 no 1778 0.474508035848199 2699 1948547 SGTC_1784 st039334 36.3 µM -0.0640045382511958 0.474597475213577 no 1779 0.474483306608787 2680 3496984 SGTC_2524 avocatin b 10.57 µM -0.064018401441236 0.474591594131157 no 1780 0.474477787315294 2551 6710748 SGTC_3151 9099821 49.47 µM -0.0645765899340811 0.474354802413886 no 1781 0.474255562161092 2602 17174189 SGTC_570 0987-0065 62.6 µM -0.0661327676271396 0.473694697188768 no 1782 0.473636061575618 2527 3104428 SGTC_2831 7999036 19.48 µM -0.0663744462578007 0.473592187484271 no 1783 0.473539857130341 2672 2988270 SGTC_12 0849-0099 9.267 µM -0.0665372315405184 0.473523141937761 no 1784 0.47347505844437 2501 6071388 SGTC_3128 9127691 49.47 µM -0.0670807367555605 0.47329261940999 no 1785 0.473258714595222 2652 41316314 SGTC_9 0092-0002 10.449 µM -0.0671480067975378 0.473264088086861 no 1786 0.473231938104432 2525 759368 SGTC_3208 9114115 49.47 µM -0.0679855656933875 0.472908864765045 no 1787 0.472898562302823 2597 650895 SGTC_1065 prochlorperazine maleate 2.48 µM -0.0682525907817238 0.472795619287938 no 1788 0.47279228157413 2532 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1868 st057644 42.7 µM -0.0683759879479478 0.472743287228671 no 1789 0.472743167963817 2518 688665 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.0685291200432993 0.472678345403855 no 1790 0.472682220057351 2588 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_665 3914-0008 307 µM -0.0689685600112908 0.472491987247238 no 1791 0.472507322682326 2536 1069549 SGTC_2288 7946289 167.31 µM -0.0693673202406117 0.472322885806348 no 1792 0.472348620454489 2554 1246052 SGTC_473 2-arachidonoylglycerol 10 µM -0.0706278230806573 0.471788379878234 no 1793 0.471846983043107 2514 5282280 An endocannabinoid. SGTC_1793 st048256 72.231 µM -0.0715622949391263 0.471392157464472 no 1794 0.471475123693869 2534 672022 SGTC_951 1171-0579 82.7 µM -0.0721538533471294 0.471141347292942 no 1795 0.471239734547874 2505 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1843 st055809 45.5 µM -0.0755271928781284 0.469711333440533 no 1796 0.469897631266661 2652 16413835 SGTC_2349 9023730 187.07 µM -0.0758829139266455 0.469560559909581 no 1797 0.469756125186412 2590 4126287 SGTC_1756 st041558 35.5 µM -0.0758886597419215 0.469558124562727 no 1798 0.469753839528402 2579 3955792 SGTC_3217 9129673 49.47 µM -0.0760352504373379 0.469495992914341 no 1799 0.469695526783709 2620 17248312 SGTC_1971 st069429 63.5 µM -0.0763607902244656 0.469358017350326 no 1800 0.469566031678694 2553 1246522 YGL099W LSG1 SGTC_505 gw-5074 63.9 µM -0.0767030610846981 0.469212954519389 no 1801 0.469429884662036 2646 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1727 st034309 9.9045 µM -0.0768192819344543 0.469163698185746 no 1802 0.46938365564914 2807 870305 SGTC_20 0481-0013 4.944 µM -0.0772322687403529 0.468988671315884 no 1803 0.469219385779797 2532 182045 SGTC_2077 5212015 200 µM -0.0781549512104267 0.468597653347099 no 1804 0.468852398040747 2518 780900 SGTC_728 3030-5151 22.5 µM -0.0791801255130492 0.468163236530668 no 1805 0.468444676248148 2549 3125388 SGTC_500 h-89 112 µM -0.0793817361079018 0.468077808641626 no 1806 0.468364497634163 2652 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2034 5197015 53.07 µM -0.0797072189028826 0.467939895838377 no 1807 0.468235058935003 2634 780676 SGTC_880 0833-0487 87.2 µM -0.0803936715502023 0.467649046374656 no 1808 0.467962079993115 2544 76075 SGTC_455 paf C-16 10 µM -0.0807126844271427 0.467513886730071 no 1809 0.467835224508275 2548 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1887 st057648 70.8 µM -0.080852825418526 0.46745451285983 no 1810 0.467779498468597 2646 688672 SGTC_2036 5160441 105 µM -0.0833155519127439 0.466411242966078 no 1811 0.466800317324694 2580 134534 YIL048W NEO1 SGTC_575 k072-0246 11.9 µM -0.0834616585434293 0.4663493558804 no 1812 0.466742231518265 2544 6796779 SGTC_336 4111-0029 111 µM -0.0836126865302956 0.466285385087531 no 1813 0.466682189933631 2607 3131175 SGTC_1993 st073995 70.8 µM -0.0845172621741152 0.465902253058891 no 1814 0.466322589357457 2596 3098394 SGTC_878 0828-0289 13.7 µM -0.0850279889817591 0.465685949210579 no 1815 0.466119569644759 2572 745350 YLR208W SEC13 SGTC_2925 9010536 32.5 µM -0.0860516865912557 0.465252421720242 no 1816 0.46571266480454 2608 2994177 SGTC_847 0342-0274 5.54 µM -0.0867230653879751 0.464968120699414 no 1817 0.465445820979549 2637 18097 SGTC_1651 st011928 86.1 µM -0.0868698055170931 0.464905984728889 no 1818 0.465387500235334 2649 720198 SGTC_1122 capsaicin 818.572 nM -0.0878952150054071 0.464471806994499 no 1819 0.464979979879518 2684 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1619 st003326 88.7 µM -0.0901255429049591 0.463527590817746 no 1820 0.464093725755479 2601 2849032 SGTC_2301 7769476 200 µM -0.0907807384821845 0.463250250552617 no 1821 0.463833407655157 2627 977820 SGTC_1203 3992-3522 103 µM -0.0909312126591182 0.463186558274516 no 1822 0.463773624403485 2698 5322312 SGTC_623 k072-0108 16.9 µM -0.0919764697530922 0.462744150983274 no 1823 0.463358367374196 2646 5382803 SGTC_2950 9072895 21.46 µM -0.0926341675665724 0.462465802567341 no 1824 0.463097099324979 2634 17332245 SGTC_3345 9148410 3.559 µM -0.09442700640343 0.46170713773167 no 1825 0.462384981819469 2600 4903596 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.0949720377320016 0.461476527587441 no 1826 0.462168518581517 2863 5282309 SGTC_2159 5658611 73.75 µM -0.0952314799780673 0.461366758601231 no 1827 0.462065483099855 2568 793844 SGTC_1292 0kpi-0043 232 µM -0.0960522070046448 0.461019531669731 no 1828 0.46173955450503 2606 3333905 SGTC_1821 st053465 65.6 µM -0.0968596923725157 0.460677935917463 no 1829 0.461418909534764 2645 675086 SGTC_2756 carbadox 75.1 µM -0.0974819526265989 0.460414716923825 no 1830 0.461171832841719 2615 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_755 1995-0008 37.3 µM -0.0996214292089974 0.45950984138884 no 1831 0.460322440203786 2572 689533 SGTC_2698 st077697 67.5 µM -0.0997051791615081 0.459474424210811 no 1832 0.460289194329324 2613 3154499 SGTC_2846 9008642 19.48 µM -0.100111125121544 0.459302757507834 no 1833 0.46012805156807 2707 2992898 SGTC_901 1112-0062 60.1 µM -0.100365864561508 0.459195036993394 no 1834 0.460026934513198 2582 1908457 SGTC_1275 0867-0008 21.1 µM -0.100928932706384 0.458956945555086 no 1835 0.45980343769807 2621 3422836 SGTC_499 genistein 192 µM -0.100965599537164 0.458941441620791 no 1836 0.459788884091394 2584 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_774 k060-0086 136 µM -0.101109393699448 0.45888064135281 no 1837 0.459731810584796 2575 5911235 SGTC_46 0329-0187a 2.197 µM -0.101803779158172 0.458587048963342 no 1838 0.459456212952009 2639 46494817 SGTC_3198 9112019 49.47 µM -0.10192707322014 0.458534921486961 no 1839 0.459407280274088 2595 45595555 SGTC_2388 9080168 200 µM -0.101997849931565 0.458504998134761 no 1840 0.459379190845276 2582 15943073 SGTC_1815 st051655 58.2 µM -0.102079403002442 0.458470518987931 no 1841 0.459346824812214 2585 5984156 SGTC_2947 9072639 7.68 µM -0.102445375833151 0.458315796219375 no 1842 0.459201584200143 2647 16488146 SGTC_3016 9080866 49.47 µM -0.102540602236677 0.458275538274107 no 1843 0.45916379337654 2597 17066299 SGTC_2752 diclazuril 33.15 µM -0.102751129393609 0.458186537264573 no 1844 0.459080246486264 2666 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_3262 9137218 49.47 µM -0.105412902827628 0.457061446569451 no 1845 0.458024089065456 2552 17650664 SGTC_1426 4048-4480 71.7 µM -0.106463875745912 0.456617310726872 no 1846 0.45760715772665 2632 14224343 SGTC_3108 9121785 49.47 µM -0.106522109451564 0.456592703036645 no 1847 0.457584057200139 2540 17140271 SGTC_2543 pimpinellin 60.67 µM -0.107631358555577 0.456124001950077 no 1848 0.457144060474502 2591 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2057 5236571 38.335 µM -0.107839960937414 0.456035866093316 no 1849 0.457061321733921 2644 54684039 YBR257W POP4 SGTC_2887 9044784 58.44 µM -0.107930813855636 0.455997480823203 no 1850 0.457025286983812 2615 6465546 SGTC_541 4513-1321 94 µM -0.108290732169688 0.45584541972311 no 1851 0.456882537020413 2612 747515 SGTC_79 0052-0007 94.094 µM -0.108845548739322 0.455611029162709 no 1852 0.456662497869874 2644 2801472 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.10915009129969 0.455482377164161 no 1853 0.456541722539088 2681 688798 SGTC_2120 5538279 151.968 µM -0.109305620301431 0.455416676761808 no 1854 0.456480044476124 2622 2058197 SGTC_549 1661-1316 519 µM -0.109636847782806 0.455276759793143 no 1855 0.456348693246047 2640 2857282 SGTC_1491 4138-0063 26.5 µM -0.110319411493441 0.454988449040853 no 1856 0.456078031539777 2588 23883227 SGTC_2071 5230951 39.92 µM -0.110864965616437 0.454758027343453 no 1857 0.455861713840721 2606 1799272 SGTC_905 2-aminofluorene 215 µM -0.111989399099745 0.454283156717816 no 1858 0.455415905993349 2609 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3182 9108849 49.47 µM -0.112766279828939 0.453955102658709 no 1859 0.45510792628788 2673 17133045 SGTC_1420 4'-methoxyflavone 42 µM -0.112950167043168 0.453877457043958 no 1860 0.455035031613714 2600 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1283 0922-0125 16.4 µM -0.113053881032868 0.453833665018584 no 1861 0.454993919050494 2687 3360884 SGTC_2881 9058953 51.95 µM -0.114026169515528 0.453423154886845 no 1862 0.454608524231564 2595 17122249 SGTC_2414 st077232 92.9 µM -0.114499174173591 0.453223465453649 no 1863 0.454421050504201 2597 729801 SGTC_1989 st071868 50.2 µM -0.117167532135171 0.452097181821294 no 1864 0.453363647634419 2686 16414057 SGTC_1520 flindersine 88 µM -0.117224294998232 0.452073227014919 no 1865 0.453341157509551 2896 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1870 st057514 26.5 µM -0.118637793038501 0.451476765464919 no 1866 0.452781161134924 2601 5393161 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.118753964418752 0.451427748840622 no 1867 0.452735140787814 2612 3256 An antibiotic and ribosome inhibitor. SGTC_2197 6588183 93.1375 µM -0.118910875092721 0.451361544109777 no 1868 0.452672982908953 2634 884136 SGTC_81 0411-0046 9.971 µM -0.122513056361464 0.449842064995298 no 1869 0.451246353201439 2597 12925265 SGTC_2959 9079155 11 µM -0.123050312560601 0.449615500992769 no 1870 0.451033628497914 2767 16189457 SGTC_2206 7254556 146.969 µM -0.123066065774828 0.449608858019993 no 1871 0.451027391280036 2676 4398905 SGTC_3308 9128332 17.569 µM -0.123207167948755 0.449549357275419 no 1872 0.450971524807833 2750 17332805 YDL196W YDL196W SGTC_2628 lathosterol 100 µM -0.12328336165664 0.44951722796311 no 1873 0.450941357897043 2740 6710616 SGTC_1986 st071812 45 µM -0.124818622519069 0.448869910982331 no 1874 0.450333572025902 2636 11838594 SGTC_2023 5144124 124 µM -0.12515190187273 0.448729407252743 no 1875 0.450201647255023 2650 2830192 SGTC_1303 1160-0052 261 µM -0.125339670213651 0.448650250807867 no 1876 0.450127323755118 2636 3562476 SGTC_748 act1.228 77.9 µM -0.126272187248372 0.448257165184014 no 1877 0.449758235686306 2628 4421505 YNR035C ARC35 SGTC_1995 st072814 61.1 µM -0.126296055285649 0.448247104711388 no 1878 0.449748789341831 2640 5769371 SGTC_2986 9022445 71.43 µM -0.128335688741315 0.447387514717839 no 1879 0.448941661539661 2700 6459286 SGTC_1927 st060202 13.8 µM -0.128364396575174 0.447375417745395 no 1880 0.448930302718438 2595 688887 SGTC_1325 1431-0015 227 µM -0.128410587366913 0.447355953867079 no 1881 0.448912026507638 2627 1103340 SGTC_1172 0370-0043 85 µM -0.128513338133191 0.447312657198396 no 1882 0.44887137172271 2772 376585 SGTC_1940 st075990 51.1 µM -0.128590240484314 0.447280252832668 no 1883 0.448840944577787 2893 1084979 SGTC_1344 1488-0097 29.1 µM -0.128833079804682 0.447177929869866 no 1884 0.448744864872516 2728 747966 SGTC_3210 9128157 49.47 µM -0.129124417383618 0.447055176283338 no 1885 0.448629600732487 2785 17590849 SGTC_3003 9075612 71.4286 µM -0.131107907109155 0.446219578528376 no 1886 0.447844973095246 2736 6501993 SGTC_2073 5212005 126 µM -0.131443981202131 0.446078021940336 no 1887 0.447712049242851 2616 691789 SGTC_2235 salicylic acid 500 µM -0.131527831011173 0.446042704927365 no 1888 0.447678885924185 2645 338 A COX inhibitor and kinase inhibitor. SGTC_3214 9129694 49.47 µM -0.131736626599832 0.44595476339746 no 1889 0.447596307067795 2714 17158655 SGTC_454 lyso-paf C-16 6.67 µM -0.132162326216472 0.445775473426766 no 1890 0.447427949499636 2700 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_820 1582-0060 59.9 µM -0.132226515453437 0.445748440098968 no 1891 0.447402564477198 2677 3848840 SGTC_527 4476-4215 268 µM -0.132592336757084 0.445594379100644 no 1892 0.447257896644427 2656 4418754 SGTC_2970 9090938 41.86 µM -0.132713590059797 0.445543316622948 no 1893 0.44720994731434 2711 17217104 SGTC_2059 5238311 157 µM -0.133328121192845 0.445284537726726 no 1894 0.446966944319167 2642 703021 SGTC_1701 st028638 40.4 µM -0.134167513256588 0.444931107642309 no 1895 0.44663505713819 2650 3490878 SGTC_5 0352-0601 109.883 µM -0.135867246835516 0.444215560954553 no 1896 0.445963114281891 2662 762456 SGTC_1970 st070122 35.8 µM -0.136524530335026 0.44393890912664 no 1897 0.445703316849644 2794 102928 SGTC_3037 9091026 49.47 µM -0.136567417790623 0.443920858665978 no 1898 0.445686365991881 2707 25236398 YIL048W NEO1 SGTC_410 α-linolenic acid 100 µM -0.13657163469953 0.443919083860784 no 1899 0.445684699304216 2765 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1140 3229-1848 2.98 µM -0.136773388064563 0.44383417157466 no 1900 0.445604959589547 2741 2849525 SGTC_248 streptozotocin 5.23457 mM -0.137295210592903 0.443614563196981 no 1901 0.44539872799099 2749 5300 DNA alkylating agent. SGTC_1242 0402-0103 60.1 µM -0.137584347491104 0.443492887735239 no 1902 0.445284463382128 2660 432868 SGTC_2561 acetosyringone 100 µM -0.139272127323773 0.442782737810735 no 1903 0.444617557187899 2638 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2430 5571206 200 µM -0.139602953529013 0.442643560909957 no 1904 0.444486853449089 2735 1731771 SGTC_2539 epi(13)torulosol 80 µM -0.140428546753504 0.442296268950112 no 1905 0.444160702136825 2740 6708597 SGTC_2515 chrysin 20.77 µM -0.142948278240856 0.441236600367839 no 1906 0.443165514771157 2763 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_4 0960-0234 25.671 µM -0.142948915524608 0.44123633241217 no 1907 0.443165263116101 2720 6821112 SGTC_1561 5-methoxyflavone 52.9 µM -0.144109760960642 0.44074828202422 no 1908 0.44270689852442 2636 94525 SGTC_3266 9136860 49.47 µM -0.144960672324487 0.440390593300239 no 1909 0.442370961340224 2658 4871271 YPR165W RHO1 SGTC_1497 4476-2978 41.3 µM -0.146528429444911 0.439731699176911 no 1910 0.441752124333622 2749 1528379 SGTC_1228 0124-0032 52.5 µM -0.147130212904918 0.439478826943029 no 1911 0.441514621463799 2733 X1228 SGTC_531 3788-1495 174 µM -0.147226092159644 0.439438540308075 no 1912 0.441476783217472 2624 2896655 SGTC_2942 9052777 62.25 µM -0.147898674143861 0.439155951835798 no 1913 0.4412113672899 2689 6469503 SGTC_1171 0368-0077 21.4 µM -0.147952316695808 0.439133414999435 no 1914 0.441190199871674 2676 3239779 SGTC_2821 7996764 71.43 µM -0.148194909898599 0.439031496822596 no 1915 0.441094474388501 2809 2987135 SGTC_3354 9151612 71.43 µM -0.149011799984819 0.438688334986311 no 1916 0.440772160940365 2788 27261949 SGTC_994 3910-0338 138 µM -0.149902930513799 0.438314038549792 no 1917 0.44042059981444 2813 3479481 SGTC_2474 5321570 43.32 µM -0.15026800040961 0.438160716250642 no 1918 0.440276589133716 2829 2841384 SGTC_71 0417-1750 47.813 µM -0.151096156979921 0.437812940946107 no 1919 0.439949931991682 2810 6811472 SGTC_1634 st006576 41 µM -0.152326339954698 0.43729642778615 no 1920 0.439464775524808 2770 3915356 SGTC_1638 st008370 60.6 µM -0.152503845521231 0.437221907867615 no 1921 0.439394778813864 2647 24207134 SGTC_2219 9098279 200 µM -0.154013617115851 0.436588169834141 no 1922 0.438799499392401 2692 902349 SGTC_730 1436-0052 41.2 µM -0.154352011295331 0.436446148586517 no 1923 0.438666094778546 2669 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2150 5556613 200 µM -0.154438526969015 0.436409839985737 no 1924 0.438631988956196 2709 743190 SGTC_1399 3562-5772 25 µM -0.154603950051701 0.436340417286483 no 1925 0.438566777876485 2667 23847490 SGTC_2931 9014674 55.67 µM -0.155324356535125 0.436038108957519 no 1926 0.438282807446121 2719 2996810 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.15686596372622 0.435391321185607 no 1927 0.437675242362833 2703 688801 SGTC_958 1222-0007 33 µM -0.157041610177593 0.43531763891296 no 1928 0.437606027377128 2830 7312461 SGTC_482 fipronil 114 µM -0.160081566100474 0.434042759807585 no 1929 0.436408411011882 2672 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_3282 9108498 15.4605 µM -0.160144264917772 0.434016472713134 no 1930 0.436383716377751 2792 16459645 SGTC_2483 5729050 27.16 µM -0.16136298184084 0.4335055717826 no 1931 0.435903760381755 2760 2865180 SGTC_1775 st081588 35.1725 µM -0.16190995195812 0.433276311334788 no 1932 0.435688382849616 2697 1426443 YGL099W LSG1 SGTC_1654 st012436 41.8 µM -0.162729789093869 0.432932721781851 no 1933 0.435365595652081 2714 4323132 SGTC_1851 st056236 18.9 µM -0.162925776744058 0.432850591857915 no 1934 0.435288437543885 2708 5393171 SGTC_1395 3486-0190 4.35 µM -0.165291570079172 0.431859420324275 no 1935 0.434357246830255 2761 6748079 SGTC_2344 7990960 76.95 µM -0.165793084591073 0.431649360941657 no 1936 0.434159894251387 2740 140813 SGTC_1357 1503-1303 39.5 µM -0.166257126077733 0.431455014350598 no 1937 0.43397730241685 2725 292895 SGTC_1841 st054148 70 µM -0.167203492964405 0.431058715101458 no 1938 0.433604968061316 2776 675442 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.167785946055239 0.430814842350718 no 1939 0.433375839588257 2683 4620898 SGTC_537 1334-0398 209 µM -0.168213973922401 0.430635644156576 no 1940 0.433207473994261 2724 5846986 SGTC_2224 6650123 117.647 µM -0.168893224803444 0.430351298237859 no 1941 0.432940314233177 2696 2908370 SGTC_236 1509-0011 5.31 µM -0.169791710693374 0.429975232331668 no 1942 0.432586973090361 2795 3107280 SGTC_1184 1269-1718 139 µM -0.169966669480545 0.429902009806454 no 1943 0.432518174556107 2849 5403821 SGTC_315 k915-0449 187 µM -0.170208067137778 0.429800985709647 no 1944 0.432423253817614 2738 20970215 YNL149C PGA2 SGTC_224 benfluorex 43.875 µM -0.170922452522837 0.429502044812742 no 1945 0.432142370943616 2769 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1111 tnp00062 510.699 nM -0.171823923649039 0.429124873934534 no 1946 0.431787978441253 2841 676306 SGTC_1831 st055328 12 µM -0.172279288762746 0.428934376089906 no 1947 0.431608983037943 2842 1103068 SGTC_2949 9072542 2.23 µM -0.172317062027715 0.428918574731692 no 1948 0.431594135712969 2809 16457352 SGTC_1862 st057513 3.81 µM -0.172730379166414 0.428745682851247 no 1949 0.431431681786621 2736 5393163 SGTC_1490 4089-0339 670 nM -0.173450297129784 0.428444571531805 no 1950 0.431148746393415 2715 742542 SGTC_3002 9075603 71.4286 µM -0.1739872394272 0.428220018323708 no 1951 0.43093774536973 2716 20105405 SGTC_1100 amiodarone 5.07 µM -0.174918942503574 0.427830428454392 no 1952 0.430571662888122 2822 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1180 1193-0155 285 µM -0.177169095410904 0.426889822121335 no 1953 0.429687784957329 2852 2921347 SGTC_1926 methyl fluorone black 53.6 µM -0.177403878895623 0.426791702049803 no 1954 0.429595580362651 2715 72721 Reacts with homocysteine. SGTC_312 4092-0653 6.84 µM -0.17806307380628 0.426516237349513 no 1955 0.429336720689327 2819 1148278 SGTC_3202 9113761 49.47 µM -0.178865558570871 0.426180942999529 no 1956 0.42902163344877 2919 4798415 SGTC_1901 st060216 58.6 µM -0.179436528863735 0.425942412544713 no 1957 0.428797475465164 2727 688792 SGTC_2227 7312221 64.1025 µM -0.179786278731865 0.425796313248756 no 1958 0.428660178038498 2736 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_568 1193-0097 7.48 µM -0.180334453186148 0.425567347525019 no 1959 0.428445004648008 2777 3646150 SGTC_1568 digitonin 820 nM -0.181645066033396 0.425020022542327 no 1960 0.427930639776609 2807 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_689 0833-0039 98 µM -0.182125373526804 0.424819477472753 no 1961 0.427742168267345 2786 5374726 SGTC_741 4582-0002 126 µM -0.182987811795789 0.424459428392427 no 1962 0.427403790963581 2728 2912688 SGTC_1339 1486-1321 22.7 µM -0.183958865682023 0.424054110116565 no 1963 0.427022862286564 2744 3469382 SGTC_856 0433-0016 11.3 µM -0.184529806441498 0.423815836685206 no 1964 0.426798923235462 2808 3911780 SGTC_1022 4477-0945 21.3 µM -0.185103053438976 0.423576628799767 no 1965 0.426574103348062 2749 4648966 SGTC_176 1486-1328 72.834 µM -0.186063969524806 0.42317571528429 no 1966 0.426197298316769 2815 22310231 SGTC_1650 st011916 45.8 µM -0.186648213405142 0.422931995842065 no 1967 0.425968231060571 2796 242528 SGTC_2651 TUB2.036 5 µM -0.186658717138839 0.422927614441273 no 1968 0.425964113040457 2819 15992207 YFL037W TUB2 SGTC_2856 9022925 19.48 µM -0.188811112814281 0.422029991957478 no 1969 0.425120430868766 2894 4944862 SGTC_935 2996-0153 430 µM -0.189522861112361 0.421733257466003 no 1970 0.424841519597545 2860 23738523 SGTC_355 1311-2252 105 µM -0.190166609889816 0.421464910871772 no 1971 0.424589287549036 2767 5338538 SGTC_2790 5423970 71.43 µM -0.191616364810617 0.420860714456305 no 1972 0.424021361392919 2903 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_521 r062-0005 13.8 µM -0.191691883586922 0.42082924652499 no 1973 0.423991782023684 2706 2832033 SGTC_866 0495-0101 262 µM -0.193292012609323 0.420162607719128 no 1974 0.423365140695243 2749 635694 SGTC_341 1486-1430 230 µM -0.193374908378162 0.420128078265836 no 1975 0.423332682382714 2729 2054753 YPL210C SRP72 SGTC_1435 4092-0789 56.7 µM -0.193762537676249 0.419966623088037 no 1976 0.423180910821881 2827 2248285 SGTC_288 1315-0019 35.1 µM -0.194006352299327 0.419865076431238 no 1977 0.423085453995024 2794 6811474 SGTC_2917 7979103 53.79 µM -0.194147051204741 0.41980647899573 no 1978 0.423030370464637 2911 2980565 SGTC_3177 9107506 49.47 µM -0.195150180189581 0.419388753458017 no 1979 0.42263768978429 2856 8897194 SGTC_2963 9082507 9 µM -0.195165274718519 0.4193824684482 no 1980 0.422631781529124 2906 16459611 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.195325057521911 0.419315939876836 no 1981 0.422569240891806 2754 5106787 A p450 inhibitor. SGTC_2571 chrysanthemic acid 100 µM -0.19551270189601 0.41923781356227 no 1982 0.422495797440477 2810 2743 An insecticide. SGTC_93 0109-0045 59.227 µM -0.195628773939798 0.419189488202216 no 1983 0.422450368535546 2703 88733 SGTC_477 mead ethanolamide 10 µM -0.197037939290561 0.418602894654689 no 1984 0.421898924226855 2737 16061185 SGTC_559 1550-0661 158 µM -0.198419763394552 0.418027858157465 no 1985 0.421358327942394 2834 5830875 SGTC_2133 5320837 200 µM -0.200189010901918 0.417291854010701 no 1986 0.420666380626047 2914 2841355 SGTC_2203 7227154 166.4 µM -0.201384207789541 0.416794817804452 no 1987 0.420199081308757 2767 896304 SGTC_2724 maprotiline 69.64 µM -0.201446718339107 0.416768825734628 no 1988 0.420174643958556 2790 4011 A tricyclic antidepressant. SGTC_1229 0139-0193 12.2 µM -0.201942930991807 0.416562511975209 no 1989 0.419980669668281 2871 3090752 SGTC_3028 9087778 49.47 µM -0.203345867177486 0.415979328039659 no 1990 0.419432353753982 2763 17217395 SGTC_3185 9108267 49.47 µM -0.203593142550484 0.415876557736593 no 1991 0.419335726181423 2844 4910486 SGTC_2415 st077333 57.7 µM -0.204416569559723 0.41553437413169 no 1992 0.419013991459848 3000 2766255 SGTC_1050 3232-1156 69.3 µM -0.204647877469667 0.415438263249712 no 1993 0.418923623071859 2802 700529 SGTC_1748 st037455 53.6035 µM -0.205316781303029 0.415160355123925 no 1994 0.418662316878536 2949 580690 SGTC_1977 st070720 65.3 µM -0.205662385522441 0.415016784257244 no 1995 0.418527321205899 2878 682188 SGTC_440 fluspirilene 35.1 µM -0.207744062460947 0.414152254952872 no 1996 0.417714405638629 3007 3396 An atypical antipsychotic. SGTC_1917 st066507 28.5 µM -0.209518296842642 0.413415735902563 no 1997 0.417021826763013 2781 3156428 SGTC_3091 9116372 49.47 µM -0.209772390367443 0.413310281631853 no 1998 0.416922661449964 2935 17169793 SGTC_1345 1488-0192 31.4 µM -0.211180172095609 0.412726135481631 no 1999 0.416373341116073 2880 658348 SGTC_1192 1488-0095 21.4 µM -0.212440591886359 0.412203299715615 no 2000 0.415881660330393 2854 915875 SGTC_2487 5918373 44.05 µM -0.213183894834603 0.41189504257369 no 2001 0.41559176480016 2778 2876279 SGTC_3054 9094397 49.47 µM -0.213201690056453 0.41188766333547 no 2002 0.415584825049338 2827 2598354 SGTC_1798 st045719 60.953 µM -0.213578495637034 0.411731418703073 no 2003 0.415437885224469 2785 3980186 SGTC_3122 9126309 49.47 µM -0.214170352619866 0.411486030015255 no 2004 0.415207107424923 2787 17591206 SGTC_1393 3470-5649 58.2 µM -0.214919222130226 0.411175592290199 no 2005 0.414915148985478 2878 4108395 SGTC_1602 st001878 87.6 µM -0.215583589337156 0.410900230850308 no 2006 0.414656174412119 2965 595405 YLR310C CDC25 SGTC_2952 9073731 13.78 µM -0.21573466989531 0.410837618348748 no 2007 0.414597287419489 2807 16457353 SGTC_2325 6158266 200 µM -0.215744916568743 0.41083337188952 no 2008 0.414593293621132 2870 3623240 SGTC_1119 parthenolide 318.541 nM -0.215985556450706 0.410733648144354 no 2009 0.414499503070203 2990 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1781 st038725 66.3 µM -0.219056347643597 0.409461588122999 no 2010 0.413303077217675 2789 4270275 YIL048W NEO1 SGTC_2685 mycophenolic acid 18.85 µM -0.22033435452738 0.408932460065934 no 2011 0.412805383232934 2854 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3200 9114385 49.47 µM -0.222925668385726 0.407860099020634 no 2012 0.411796679273794 2944 17018030 YLR208W SEC13 SGTC_1504 k297-0033 30 µM -0.225711883870332 0.40670785183684 no 2013 0.410712757299673 2767 4388117 SGTC_2854 9024559 71.43 µM -0.226604187178203 0.406339007484991 no 2014 0.410365768045096 2892 3163529 SGTC_444 curcumin 90.4 µM -0.226658327411592 0.406316630636114 no 2015 0.410344716831778 2941 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3134 9127454 49.47 µM -0.227380211122954 0.406018296158769 no 2016 0.410064053278349 2837 24262820 SGTC_222 nsc-310342 10.666 µM -0.228598769367755 0.405514823776882 no 2017 0.409590390572838 2799 432556 SGTC_544 k015-0020 52.4 µM -0.228776660348321 0.405441337515623 no 2018 0.40952125403739 2850 3008304 SGTC_2194 5927483 104.545 µM -0.229348408269121 0.405205172649249 no 2019 0.409299065824629 2796 760979 SGTC_219 mitoxanthrone 164.414 µM -0.229744977902002 0.405041386785145 no 2020 0.409144971137808 2873 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1956 st077085 54 µM -0.231979864237553 0.404118675804129 no 2021 0.408276826624993 2860 24208685 SGTC_2529 gangaleoidin 93.61 µM -0.232365167263997 0.403959650613786 no 2022 0.408127200523015 2807 4565183 SGTC_273 hydroxyurea 18.1 mM -0.232369418563687 0.403957896073582 no 2023 0.408125549675283 2808 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2399 5884133 200 µM -0.234305122304735 0.403159219282813 no 2024 0.407374054786291 2842 722445 SGTC_2003 4023581 200 µM -0.236479382788199 0.402262594960135 no 2025 0.406530351899662 2963 16641307 SGTC_1493 4348-0038 111 µM -0.23671718740096 0.402164559888728 no 2026 0.406438100129449 2860 800424 SGTC_1035 k081-0041 55.2 µM -0.237110186821697 0.402002559171394 no 2027 0.40628565487398 2924 731709 SGTC_1347 1493-0251 600 nM -0.237753159665383 0.401737551679797 no 2028 0.406036275072781 2949 3986378 SGTC_2417 cerulenin 830 nM -0.239360200058253 0.401075392223918 no 2029 0.405413144414257 2857 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2408 sulbentine 18.36 µM -0.239511818188348 0.401012934640354 no 2030 0.405354366761802 2902 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_39 0986-0283 58.349 µM -0.240071631365341 0.400782347086049 no 2031 0.405137363033522 2997 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1555 citronellol 128 µM -0.242366942967508 0.399837268394731 no 2032 0.404247923278797 2914 8842 A terpine precursor. SGTC_2629 bisabolol 100 µM -0.243627807847266 0.39931836518168 no 2033 0.403759544779166 2985 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2666 tannic acid 100 µM -0.244170995632986 0.399094873468609 no 2034 0.403549194721044 2912 16134267 A thiamine antagonist. SGTC_1746 st038117 42 µM -0.24427453644188 0.399052275906567 no 2035 0.40350910159455 2935 2898218 SGTC_2177 5811945 192 µM -0.245502100516592 0.398547337440466 no 2036 0.403033840977439 2995 5343475 SGTC_1408 3909-7976 48.8 µM -0.246806211253662 0.398011098764302 no 2037 0.402529101643325 2877 24152374 SGTC_2074 5212007 75.395 µM -0.24789754345948 0.397562500691376 no 2038 0.402106840316312 2907 758611 SGTC_2028 5153890 36.43 µM -0.250110772699779 0.39665315713262 no 2039 0.401250842639022 2852 2830968 YPR165W RHO1 SGTC_1211 1056-0033 32.3 µM -0.25117902390854 0.396214448327275 no 2040 0.400837850649985 2950 6741922 SGTC_1038 k292-0204 154 µM -0.253102947005521 0.395424664437706 no 2041 0.400094330814449 2822 4454212 SGTC_3043 9092303 49.47 µM -0.253600048307242 0.395220670538119 no 2042 0.399902279653807 2883 25236084 SGTC_186 3455-3465 67.277 µM -0.253886594487465 0.395103094523943 no 2043 0.39979158579771 2834 755278 SGTC_271 rotenone 740 µM -0.25471361132714 0.3947638054554 no 2044 0.399472151303724 2995 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2541 muurolladie-3-one 83.07 µM -0.255224698129202 0.394554168630368 no 2045 0.399274778121156 3024 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1444 4112-3581 28 µM -0.255752226596407 0.394337819810367 no 2046 0.399071082442467 2862 2877249 SGTC_1259 0671-0132 43 µM -0.256165351783275 0.394168412566644 no 2047 0.398911580727836 2878 X1259 SGTC_619 1652-1634 108 µM -0.256346280633287 0.394094226689546 no 2048 0.398841732004803 2896 5400454 SGTC_652 0437-0092 114 µM -0.256712864116866 0.393943929014054 no 2049 0.398700220073707 2871 3091274 SGTC_3312 9133330 71.43 µM -0.25678323232988 0.393915080151063 no 2050 0.39867305741121 3007 17617324 SGTC_2126 5251174 33.877 µM -0.258414178519773 0.393246604403346 no 2051 0.398043637621209 3012 790722 SGTC_3099 9120367 49.47 µM -0.259797944142327 0.392679687141211 no 2052 0.397509818428694 2851 24824940 SGTC_2304 7443016 91.4 µM -0.260159388920186 0.392531643666282 no 2053 0.397370414416502 2797 939854 SGTC_3140 9094243 49.47 µM -0.260862165554395 0.392243839255693 no 2054 0.397099401190498 2841 19291112 SGTC_2119 5528445 120.635 µM -0.261478667880381 0.391991414827291 no 2055 0.396861699008432 2995 791935 SGTC_1225 1216-0074 20.6 µM -0.261527075394813 0.39197159648604 no 2056 0.396843036350053 2888 4241466 SGTC_225 nsc-122657 1.016 µM -0.26232042070516 0.391646835892667 no 2057 0.396537209836368 2991 275685 SGTC_1467 k284-1082 293 µM -0.26369545669004 0.39108413572624 no 2058 0.396007298349794 2976 3334705 SGTC_2744 captopril 92.04 µM -0.264202184254165 0.390876827156383 no 2059 0.395812064029983 2970 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3323 9138564 53.9225 µM -0.264487139191035 0.390760262153166 no 2060 0.395702286763256 3032 43912313 YNL103W MET4 SGTC_244 nsc-207895 1.295 µM -0.26547531574067 0.390356110118703 no 2061 0.395321661519354 2819 42640 SGTC_97 0535-0701 19.132 µM -0.265577192015983 0.390314450705509 no 2062 0.395282426548586 2909 2832013 YGL099W LSG1 SGTC_1487 3970-0795 2.82 µM -0.265639305426079 0.390289051806203 no 2063 0.395258505721517 2959 3765103 SGTC_808 0711-0032 135 µM -0.265838418840512 0.390207635161026 no 2064 0.395181826752103 2946 4252555 SGTC_647 0140-0236 81 µM -0.267698796448542 0.389447167643756 no 2065 0.39446558815401 2913 990837 SGTC_1715 st032160 10.2275 µM -0.267927633111571 0.38935365513099 no 2066 0.394377511456902 2990 5289825 SGTC_2079 5212404 121 µM -0.268962740628308 0.388930745746636 no 2067 0.393979177557256 3004 758462 SGTC_1806 st050005 60.3 µM -0.26944725196487 0.388732836229038 no 2068 0.39379276418817 2888 5194765 SGTC_22 0964-0034 14.468 µM -0.269571630032842 0.388682035874368 no 2069 0.393744914257974 2905 138402 SGTC_1290 0986-0249 10.2 µM -0.270681140146739 0.388228957450906 no 2070 0.39331814173195 2950 53329 SGTC_1149 3909-7961 23.3 µM -0.271229368674351 0.388005139501281 no 2071 0.393107313169822 2899 735261 SGTC_1107 amlodipine 47 µM -0.272237019977788 0.387593856207311 no 2072 0.392719889277413 2943 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2546 rhodinyl acetate 100 µM -0.274022219307793 0.386865518514399 no 2073 0.392033773210751 3043 6708682 SGTC_380 3970-0968 6 µM -0.275849039438883 0.386120612339005 no 2074 0.391332008176314 2900 2891601 SGTC_23 0213-0011 39.996 µM -0.27675080165492 0.385753063303011 no 2075 0.390985730329189 3060 627608 SGTC_75 0159-0059 199.013 µM -0.27687787423363 0.38570127805859 no 2076 0.390936941236058 3199 5377270 SGTC_2703 st077852 53.4 µM -0.276903713438721 0.385690748187414 no 2077 0.390927020569359 3034 6281836 SGTC_626 0214-0009 33 µM -0.276938009520839 0.385676772139643 no 2078 0.390913853091266 3012 3437874 SGTC_194 1486-1323 56.904 µM -0.277040976008827 0.385634813003748 no 2079 0.39087432136869 2940 5178754 SGTC_770 0389-1121 67.2 µM -0.278354588433518 0.385099629818866 no 2080 0.390370087811188 3077 6753108 SGTC_282 k297-0036 65.7 µM -0.280089667506557 0.38439307099557 no 2081 0.389704355856329 3047 5061378 SGTC_1825 st052143 62.6 µM -0.282190504623796 0.383538082213195 no 2082 0.388898719399228 3070 674173 SGTC_3222 9128301 49.47 µM -0.282272206820215 0.38350484286167 no 2083 0.388867397575982 2924 4911358 SGTC_1731 st035964 63 µM -0.28557761396989 0.382160807503233 no 2084 0.387600825588387 2937 6739575 SGTC_1478 0453-0656 35.7 µM -0.287275522667794 0.381470959144972 no 2085 0.386950681597979 2962 5258496 SGTC_1084 voriconazole 435 nM -0.288462492048587 0.380988925217315 no 2086 0.386496368897249 3031 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1104 tacrolimus 29.8 µM -0.28904625299276 0.380751924795683 no 2087 0.386272991329911 2944 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_699 0375-0592 111 µM -0.289168372089861 0.380702351462155 no 2088 0.386226266920133 3028 762578 SGTC_2691 st077356 60.2 µM -0.289401226953844 0.380607831201298 no 2089 0.386137178088942 3089 2839272 SGTC_1074 carmofur 3.8 µM -0.290137510896267 0.380309006327138 no 2090 0.385855519928622 2921 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1663 st014140 55.4 µM -0.290187500696178 0.380288720279976 no 2091 0.385836399003152 2951 4207120 SGTC_3153 9100258 49.47 µM -0.290901298099142 0.3799990945751 no 2092 0.38556340424446 2938 25236848 SGTC_827 3253-0474 693 µM -0.291258711995992 0.379854097951157 no 2093 0.385426731114485 3051 5402065 SGTC_2310 7668677 200 µM -0.293327652092111 0.379015097245552 no 2094 0.384635859714269 3141 2197143 SGTC_725 1497-0963 19 µM -0.293348302606601 0.379006725872737 no 2095 0.384627968278305 3046 3549977 SGTC_2782 7736369 71.43 µM -0.293924106234308 0.378773327588496 no 2096 0.384407948592706 2969 2950836 YOL077C BRX1 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.294689975054022 0.378462956114274 no 2097 0.384115361016169 2991 676296 Flavone; oxidizing agent. SGTC_447 ml7 120 µM -0.294703957570947 0.378457290370094 no 2098 0.384110019838991 2989 4216 Selective myosin light chain kinase inhibitor. SGTC_773 4358-1457 44.6 µM -0.295290175981694 0.378219777007684 no 2099 0.383886110271509 3100 1186886 SGTC_2813 7971799 71.43 µM -0.295316567623381 0.378209085201815 no 2100 0.383876030740009 3031 2234054 SGTC_552 k242-0005 476 µM -0.295801284779986 0.378012732740736 no 2101 0.383690920885502 3052 4088318 SGTC_214 4373-3496 70 µM -0.296243478612259 0.377833633392402 no 2102 0.383522073518224 2966 3779166 SGTC_1554 st069299 38.7 µM -0.296833194042262 0.37759482504251 no 2103 0.38329693090012 3001 24207999 SGTC_837 0091-0265 12.5 µM -0.297145996607179 0.377468172990514 no 2104 0.383177524564498 2929 759367 SGTC_1449 4112-4002 201 µM -0.297277770702219 0.377414822321978 no 2105 0.383127225671469 2956 2059539 SGTC_328 k915-0120 63.5 µM -0.297913654451101 0.377157408387732 no 2106 0.382884533074557 3044 6624543 SGTC_1009 4106-0057 9.87 µM -0.298082163159559 0.377089203034907 no 2107 0.382820227423088 3081 2928005 SGTC_1158 4092-0494 91.8 µM -0.298387858478465 0.376965480008141 no 2108 0.382703577385758 3074 1148199 SGTC_253 dyclonine 31.25 µM -0.29997024933846 0.376325246526917 no 2109 0.382099924401494 2944 3180 An oral anasthetic. SGTC_1485 3909-9022 254 µM -0.300729720993391 0.376018085877324 no 2110 0.381810301600891 2975 714516 SGTC_1911 st060208 74.3 µM -0.30253244537358 0.375289306932848 no 2111 0.381123101833134 3045 688783 SGTC_1618 st003135 44.5 µM -0.303853747342029 0.374755432753236 no 2112 0.38061965845812 2967 1270615 SGTC_1152 3909-8331 15.9 µM -0.30438404442977 0.37454123278234 no 2113 0.380417661084153 2973 16001939 SGTC_2353 9059630 146.67 µM -0.305149232429651 0.374232222864775 no 2114 0.380126248042526 3056 4779114 SGTC_2232 chlorophetanol 41.5365 µM -0.305340368923707 0.374155047805225 no 2115 0.380053466522831 3013 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2945 9067681 61.76 µM -0.305726020262665 0.373999348967526 no 2116 0.379906629998438 2908 16456930 SGTC_634 1611-4317 11.2 µM -0.306525817539879 0.373676512722919 no 2117 0.379602162849642 2980 2843522 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.306821243734082 0.373557287051127 no 2118 0.379489718753367 3070 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1146 3579-1023 7 µM -0.306838251092179 0.373550423729805 no 2119 0.379483245781719 3059 X1146 SGTC_220 paclitaxel 373.376 µM -0.307596214275404 0.373244588353256 no 2120 0.379194800603436 3049 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1865 st057639 52.2 µM -0.308194891225994 0.373003080815494 no 2121 0.378967019805107 2912 688818 SGTC_1045 1348-1485 165 µM -0.308910468672791 0.372714480841884 no 2122 0.378694816589381 2932 6810614 SGTC_203 k066-0004 30.888 µM -0.309084816196081 0.372644175453622 no 2123 0.378628504497507 3014 6795412 SGTC_1327 1436-0082 2.18 µM -0.309669296893921 0.372408515417445 no 2124 0.378406226657847 2973 15992205 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.311948906017118 0.371489844277018 no 2125 0.377539677020434 3061 140250 A respiratory chain inhibitor. SGTC_2329 6138490 200 µM -0.312252523901868 0.371367542869817 no 2126 0.377424308908683 3170 720019 SGTC_2267 7931562 200 µM -0.312437433077239 0.371293065304906 no 2127 0.37735405285111 2914 934880 SGTC_2376 9072922 81.32 µM -0.312718861861049 0.371179720901845 no 2128 0.377247132054473 3075 17087968 SGTC_2792 7535235 81.82 µM -0.313068918842474 0.371038752338256 no 2129 0.37711415107398 3028 1281891 SGTC_1581 himbacine 57.9 µM -0.313205480532338 0.370983763395853 no 2130 0.377062277449295 2957 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1808 st050063 61.5 µM -0.314117854114597 0.370616447931509 no 2131 0.376715764860033 3120 4011993 SGTC_1943 st076331 65.2 µM -0.314815280485768 0.370335748258906 no 2132 0.376450954543072 3075 24208415 SGTC_3038 9091290 49.47 µM -0.315466204256538 0.370073827195999 no 2133 0.376203853546291 3122 25236843 SGTC_875 0709-0210 25.7 µM -0.316042895625404 0.369841826361535 no 2134 0.375984974731288 3103 6251364 SGTC_1622 st003707 19.4 µM -0.316179485566441 0.369786883661137 no 2135 0.375933138900198 3092 10140899 SGTC_2117 5521686 200 µM -0.316418304304 0.369690826266211 no 2136 0.375842512658632 2938 803312 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.31669772626583 0.369578447812617 no 2137 0.375736487117133 3044 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1888 azatryptophan 97.5 µM -0.316974280250183 0.369467233776879 no 2138 0.375631559056225 3071 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2374 9071832 200 µM -0.317178655097164 0.369385053037511 no 2139 0.375554022577799 2932 17381698 SGTC_406 estrone 100 µM -0.317190508379355 0.369380286922235 no 2140 0.375549525790336 3136 5870 A steroid. SGTC_1519 esterone 74 µM -0.318241214301228 0.368957885842209 no 2141 0.375150986031309 2945 698 A steroid. SGTC_1758 st042942 75.2445 µM -0.319036680859757 0.368638200392839 no 2142 0.374849348864026 2996 669317 SGTC_3143 9086658 49.47 µM -0.319215899149042 0.368566187929831 no 2143 0.374781400692767 3020 25236626 SGTC_1483 3453-0561 55.9 µM -0.32035978163487 0.368106668487677 no 2144 0.374347804907001 3063 4546991 SGTC_2767 sibutramine 71.45 µM -0.321958357796086 0.367464806060824 no 2145 0.373742120899646 3178 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2134 5324836 1.464 µM -0.321984177627998 0.367454441879956 no 2146 0.37373234058561 2981 699272 SGTC_732 3970-1727 52.7 µM -0.322681810108338 0.367174446060311 no 2147 0.373468114637598 3080 1275699 SGTC_90 0870-0863 4.608 µM -0.324223840427016 0.36655580069247 no 2148 0.372884287040472 2935 1738164 SGTC_2446 5162541 200 µM -0.324342464566976 0.366508224344997 no 2149 0.372839386865502 2946 1549321 SGTC_740 k014-0057 261 µM -0.324477301230259 0.366454148164084 no 2150 0.372788352220066 3078 4012779 SGTC_2185 6113692 200 µM -0.324821747745276 0.366316020089328 no 2151 0.372657991988548 3104 874150 SGTC_2670 beta-carotene 100 µM -0.324908391260247 0.366281277501855 no 2152 0.372625202926635 3086 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_3290 9121031 71.43 µM -0.325388385940666 0.366088827596482 no 2153 0.372443572183489 3012 17014854 SGTC_890 0929-0006 47.2 µM -0.325571558202167 0.366015395066997 no 2154 0.372374266986973 2979 1378169 SGTC_308 4092-1169 104 µM -0.325860168974911 0.365899702905393 no 2155 0.372265076381949 2989 2268590 YDL196W YDL196W SGTC_2842 9000675 19.48 µM -0.326066660356947 0.36581693650449 no 2156 0.372186960446942 3031 2989072 SGTC_2719 novobiocin 32.65 µM -0.326171718904707 0.365774829066951 no 2157 0.372147218692033 3104 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2671 danthron 100 µM -0.32862659013478 0.364791378678794 no 2158 0.371218973673837 3045 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_914 3820-6779 408 µM -0.328748759934898 0.364742459183887 no 2159 0.37117279788758 2939 2893481 SGTC_2809 7964133 12.99 µM -0.329122616825258 0.364592772284703 no 2160 0.37103150496562 3017 1253665 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.330365735827006 0.364095193943511 no 2161 0.370561814157597 2944 5355888 SGTC_2295 7971645 200 µM -0.330549581123048 0.364021626331071 no 2162 0.370492367776827 3023 2978226 YKL099C UTP11 SGTC_2011 4012611 177 µM -0.331057866055073 0.363818256901534 no 2163 0.370300388374718 2961 2049887 SGTC_269 exalamide 29 µM -0.333154230057639 0.362979888480094 no 2164 0.36950893277133 3004 3316 A derivative of salicylamide. SGTC_426 0988-0037 14.6 µM -0.334247670775539 0.362542864743717 no 2165 0.369096337192227 3199 5383008 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.335631538561824 0.361990020551406 no 2166 0.3685743689601 3092 1377 SGTC_1897 st060201 15 µM -0.335656824618969 0.361979921646612 no 2167 0.368564833799317 3008 611878 SGTC_2606 farnesol 9.78 µM -0.335929513302171 0.361871019629862 no 2168 0.368462010319709 3165 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1522 st012842 45.6 µM -0.338057741618555 0.361021466946005 no 2169 0.367659837489816 2910 3491067 YOR116C RPO31 SGTC_3027 9089541 49.47 µM -0.338883664006876 0.3606919570253 no 2170 0.367348685644529 3097 9943819 SGTC_1189 1431-2119 7.28 µM -0.338927231373641 0.360674578261563 no 2171 0.36733227481561 3009 3107275 SGTC_799 1310-0557 151 µM -0.340084677786668 0.360212985229728 no 2172 0.366896380089525 3159 5354492 SGTC_42 0133-0086 60.653 µM -0.340970549339003 0.359859834629579 no 2173 0.366562876417658 2937 162923 Model of phenazepam hydroxylation. SGTC_156 3474-0145 5.642 µM -0.341496891514631 0.359650066186638 no 2174 0.366364772296707 3075 2265471 SGTC_672 1441-0018 53.7 µM -0.344888877051143 0.358299240682836 no 2175 0.365088956493218 2993 251141 SGTC_2155 5570423 76 µM -0.345038056749326 0.358239871855879 no 2176 0.365032880198085 3022 797402 SGTC_2690 usnic acid 100 µM -0.348186160016888 0.356987827074813 no 2177 0.363850190486879 3263 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2581 avocatin a 64 µM -0.348552041342225 0.356842410500345 no 2178 0.363712818843304 3051 6710728 A skin care supplement. SGTC_2331 7980721 200 µM -0.348634184812173 0.356809766100702 no 2179 0.363681980148099 3063 2981221 SGTC_999 SEC7.066 22.7 µM -0.35033959263911 0.356132262086777 no 2180 0.363041927539753 3014 740511 YDR170C SEC7 SGTC_1319 1306-0155 43.7 µM -0.352658924114562 0.35521159462878 no 2181 0.362172078506119 3027 3122360 SGTC_1489 4065-0444 182 µM -0.353149752533535 0.355016866511195 no 2182 0.361988087783363 3144 2877968 SGTC_1694 st024011 44.9 µM -0.354176372896719 0.354609694205581 no 2183 0.361603354573418 3125 2787533 SGTC_2718 lomofungin 53.02 µM -0.355077621267706 0.35425238308801 no 2184 0.361265720675985 3179 5351222 A RNA synthesis inhibitor. SGTC_460 trequinsin 123 µM -0.355703772005825 0.35400421333927 no 2185 0.361031209952327 3103 5537 A vasodilator. SGTC_2192 5915882 198.485 µM -0.357113460161586 0.353445721995184 no 2186 0.360503434118459 3049 2876149 SGTC_1297 1068-0111 14.1 µM -0.357348970148582 0.353352448181148 no 2187 0.360415286956352 3021 767057 SGTC_1433 4060-0023 7.6 µM -0.360432888224557 0.352131875940089 no 2188 0.359261717900534 3162 3840627 SGTC_2263 7948595 193.29 µM -0.360544526061879 0.352087719690761 no 2189 0.359219982677516 3003 2971371 SGTC_882 0843-0131 351 µM -0.362094779525351 0.351474752423689 no 2190 0.358640602336217 3170 5425421 SGTC_3334 9142812 21.919 µM -0.362808584847121 0.351192644854838 no 2191 0.358373939225534 3143 45283678 SGTC_3235 9132602 49.47 µM -0.363050075813395 0.351097222215605 no 2192 0.358283738751634 3159 4912240 SGTC_928 2764-0428 58.7 µM -0.363197259316558 0.351039068791988 no 2193 0.35822876739857 3149 662578 SGTC_2678 equilin 100 µM -0.364139869685836 0.350666718375744 no 2194 0.357876782934868 3163 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1705 st027868 56.3335 µM -0.364913234975601 0.35036133031251 no 2195 0.357588087250049 3106 292948 SGTC_2540 epiandrosterone 100 µM -0.365074711072771 0.350297578499972 no 2196 0.35752781882761 3060 441302 A steroid. SGTC_2575 plumbagin 510 nM -0.366240481855755 0.349837449855 no 2197 0.357092818648717 2993 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1744 st037937 38.9 µM -0.367510494530282 0.349336427929881 no 2198 0.356619132600808 3244 1016152 SGTC_1415 3966-0071 78.1 µM -0.3681274891276 0.349093117280628 no 2199 0.356389087284901 3127 2893185 SGTC_2596 sinensetin 100 µM -0.368664875262104 0.348881250606976 no 2200 0.356188766405548 3085 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3141 9094609 49.47 µM -0.369221222749125 0.348661957972657 no 2201 0.355981419130534 3007 25236309 YDL196W YDL196W SGTC_553 k007-0256 45.7 µM -0.36946284792782 0.348566733557959 no 2202 0.355891380178936 3101 6287000 SGTC_1762 st045503 25.4615 µM -0.369485009750712 0.348558000067421 no 2203 0.355883122222982 3119 4645554 SGTC_212 3807-4682 38.772 µM -0.36954760690378 0.348533332329667 no 2204 0.3558597975876 3134 3125501 YBL034C STU1 SGTC_2348 9022543 33.42 µM -0.369713343723637 0.348468023308594 no 2205 0.355798044175581 3174 3162678 YDL140C RPO21 SGTC_1316 1272-0050 65.9 µM -0.370154123396102 0.348294354804713 no 2206 0.355633828424621 3052 7340392 SGTC_411 enrofloxacin 100 µM -0.370534455193799 0.348144528501499 no 2207 0.355492154510299 3226 71188 A bacterial gyrase inhibitor. SGTC_1364 1653-0028 37.6 µM -0.371322406186683 0.347834201843502 no 2208 0.355198705647918 3104 5718652 SGTC_2489 cantharidin 73.42 µM -0.373749768733067 0.346878850555502 no 2209 0.354295247070515 3044 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3273 9137859 49.47 µM -0.375549704363637 0.346171066958636 no 2210 0.353625844036869 3139 2377234 SGTC_1613 st002381 52.1 µM -0.377053684273891 0.345580072845029 no 2211 0.353066854894198 3142 551167 SGTC_2728 chlorpromazine 9.18 µM -0.37813201536702 0.345156570358511 no 2212 0.352666263041237 3056 2726 A thorazine and dopamine antagonist. SGTC_2364 9055074 200 µM -0.378949813299455 0.344835518576948 no 2213 0.352362566157584 3156 6470630 SGTC_661 1304-0007 33.6 µM -0.379198870470369 0.344737765686347 no 2214 0.352270095141256 3092 3117130 SGTC_325 2810-4341 181 µM -0.379669086330102 0.344553238091377 no 2215 0.352095535188363 3177 774970 SGTC_43 0570-0105 72.5 µM -0.379952439177034 0.344442059316362 no 2216 0.351990360119298 3066 1114046 YDL195W SEC31 SGTC_3313 9133968 57.047 µM -0.380007763300195 0.344420353432455 no 2217 0.351969826201104 3114 1494643 SGTC_2737 bleomycin 30.5 nM -0.380021733988888 0.344414872249078 no 2218 0.351964640954859 3115 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_114 0364-0001 490.298 µM -0.380053228583014 0.344402515952613 no 2219 0.351952951780568 3137 4003655 SGTC_1530 rhein 70.4 µM -0.381299184143742 0.343913822675958 no 2220 0.351490629484868 3065 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_3011 9081274 71.4286 µM -0.381351924391928 0.343893142445929 no 2221 0.351471064611872 3076 6625322 SGTC_2465 5809242 33.21 µM -0.381824463935831 0.343707873557808 no 2222 0.351295785764715 3075 2731748 SGTC_3258 9138477 49.47 µM -0.383224374009319 0.343159230336144 no 2223 0.350776703585622 3116 4970355 SGTC_2258 7960471 200 µM -0.383907783138978 0.342891513242511 no 2224 0.350523398741558 3145 2974708 SGTC_3123 9126162 49.47 µM -0.384343427797484 0.342720895974195 no 2225 0.350361962201069 3049 25239884 SGTC_2289 7946404 165.07 µM -0.384434688205854 0.342685158518329 no 2226 0.35032814731767 3050 1246120 YPR165W RHO1 SGTC_3120 9124077 49.47 µM -0.385619125169321 0.34222146237809 no 2227 0.349889383458597 3121 18774327 YGL155W CDC43 SGTC_2366 9070441 60.58 µM -0.386180313798086 0.342001845188488 no 2228 0.349681566176009 3077 6837235 SGTC_3121 9125696 49.47 µM -0.386605856182889 0.341835347818146 no 2229 0.349524010923374 3129 1235365 SGTC_233 rapamycin 362 pM -0.387621746978309 0.341437995619565 no 2230 0.349147986528944 3149 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3196 9111891 49.47 µM -0.388149869569161 0.341231496859493 no 2231 0.348952564358856 3098 18891510 SGTC_2882 9058044 58.44 µM -0.389267554718076 0.340794632797818 no 2232 0.348539117419569 3164 18076804 SGTC_3233 9132340 49.47 µM -0.391736394969178 0.339830406509784 no 2233 0.347626497823759 3090 17682950 SGTC_92 0063-0024 660.874 µM -0.391978350350388 0.339735965038306 no 2234 0.347537105152803 3133 3594437 SGTC_326 k292-0812 17.5 µM -0.393276331882928 0.339229500986252 no 2235 0.347057698613523 3184 3579357 SGTC_1332 1480-0653 17.5 µM -0.395184366546334 0.338485525384387 no 2236 0.346353414691062 3235 5749438 SGTC_2053 5265679 138 µM -0.395227199729379 0.338468831207109 no 2237 0.346337610411397 3069 764595 SGTC_860 0443-0016 25.1 µM -0.396227634341107 0.338079003477521 no 2238 0.345968553400338 3119 5337942 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.396711467726788 0.337890535981753 no 2239 0.345790121323103 3210 6708760 SGTC_592 k241-0073 46.5 µM -0.396856518695989 0.337834042229204 no 2240 0.345736634897759 3238 4230158 SGTC_2138 5575593 77.673 µM -0.399342117051207 0.336866531922015 no 2241 0.344820568899045 3124 762213 SGTC_2096 5468907 200 µM -0.401418594772566 0.33605909677886 no 2242 0.344055980663052 3194 759785 SGTC_2136 5328288 199.296 µM -0.402162203013391 0.335770129482839 no 2243 0.343782328444922 3116 262395 SGTC_3332 9141069 11.198 µM -0.402665290275585 0.335574684048661 no 2244 0.343597235762673 3089 17332883 SGTC_1797 st048695 56.8 µM -0.403743338394545 0.335156020685098 no 2245 0.343200733418025 3215 592262 YIL048W NEO1 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.407172483154588 0.333825664804174 no 2246 0.341940655085539 3301 94937 An inhibitor of serotonin biosynthesis. SGTC_824 1304-0008 100 µM -0.408298878725133 0.333389127671674 no 2247 0.341527131197576 3132 768245 SGTC_1591 genipin 88.4 µM -0.409265902547735 0.333014535325077 no 2248 0.341172267756083 3244 442424 A DNA cross-linking agent. SGTC_3294 9122953 26.2835 µM -0.409666297627035 0.332859484541919 no 2249 0.341025378054528 3127 16459826 SGTC_1003 4049-0218 100 µM -0.409986480218006 0.332735516163192 no 2250 0.340907932594182 3280 295161 SGTC_2915 7971052 15.16 µM -0.410209433486955 0.33264920385725 no 2251 0.340826160708298 3178 5741558 SGTC_727 3032-0951 202 µM -0.41064097729501 0.332482164718726 no 2252 0.340667905959916 3152 3652836 SGTC_1147 3809-1045 12.3 µM -0.411534517592871 0.33213640478117 no 2253 0.340340318096015 3139 325925 SGTC_1039 k821-0043 94 µM -0.411926210823095 0.331984882124209 no 2254 0.340196754305082 3253 15992768 SGTC_1262 0737-0114 49.6 µM -0.412406067163974 0.331799291883038 no 2255 0.340020908454018 3290 765919 SGTC_560 2332-1943 155 µM -0.412621755824617 0.33171588512741 no 2256 0.339941879555976 3156 21177716 SGTC_2352 9027995 87.8 µM -0.412954469852857 0.331587241048129 no 2257 0.339819986045711 3166 2997347 SGTC_2469 5655019 90.81 µM -0.413049325256452 0.331550568787079 no 2258 0.339785237773596 3248 2788239 SGTC_801 0866-0028 10.1 µM -0.415151944773599 0.330738085454582 no 2259 0.33901533758465 3094 6849771 SGTC_931 2812-0076 566 µM -0.4156297096623 0.33055358098255 no 2260 0.338840491610946 3109 3450959 SGTC_256 clotrimazole 625 nM -0.41608241343132 0.330378792665929 no 2261 0.338674849201008 3195 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_141 0443-0274 32.331 µM -0.41703293449915 0.33001191819421 no 2262 0.338327159084074 3301 1627241 SGTC_403 arphamenine a 50 µM -0.417077392743015 0.329994762557022 no 2263 0.338310900120349 3166 5487158 An arginine aminopeptidase inhibitor. SGTC_2315 7733312 200 µM -0.417603839103086 0.329791643560084 no 2264 0.338118394700462 3110 726316 SGTC_1118 chelidonine 707.474 nM -0.419218459666467 0.32916898710065 no 2265 0.337528241187215 3242 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1006 4099-6547 255 µM -0.41955671640271 0.32903860293414 no 2266 0.337404656867948 3252 3146833 SGTC_666 0272-0154 136 µM -0.42131671078345 0.328360532844943 no 2267 0.33676191464865 3181 6870312 SGTC_1005 4092-0690 4.4 µM -0.421516007049736 0.328283785877252 no 2268 0.336689162525883 3158 1529343 SGTC_54 0159-0055 9 µM -0.422712530259449 0.327823169394517 no 2269 0.336252506178615 3366 3319099 SGTC_2090 5301565 104.445 µM -0.422730101430154 0.327816407103001 no 2270 0.336246095440966 3145 2056344 SGTC_113 0099-0221 2.5 µM -0.422943164634653 0.327734413901446 no 2271 0.336168364381552 3311 89219 SGTC_724 3910-0327 137 µM -0.423828528735854 0.327393787862339 no 2272 0.33584543533577 3229 2885483 SGTC_677 0929-0063 136 µM -0.424257917151907 0.327228641013732 no 2273 0.335688863167772 3208 1539583 SGTC_1238 0333-0287 48.8 µM -0.424508607650949 0.327132238707738 no 2274 0.335597464582979 3184 7226 SGTC_1459 k035-0031 35.7 µM -0.425304144072196 0.32682639386673 no 2275 0.335307486494869 3111 3877128 YMR208W ERG12 SGTC_1268 0828-0275 2.46 µM -0.428429355561346 0.325626030452987 no 2276 0.334169278057152 3252 745337 SGTC_2844 9010103 25.97 µM -0.428682950197205 0.325528706267989 no 2277 0.334076985052731 3294 2480525 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.429439244940587 0.325238527207911 no 2278 0.333801799417531 3364 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2007 4011539 71.82 µM -0.433135953215159 0.323821682316928 no 2279 0.332458002302135 3134 45595301 SGTC_490 phenamil 164 µM -0.43482923776508 0.323173543645961 no 2280 0.331843190403207 3214 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1007 4101-0031 70 µM -0.435230609576701 0.323019989096761 no 2281 0.331697523263645 3289 1146276 SGTC_2158 5657123 3.6195 µM -0.435925356039105 0.32275426823078 no 2282 0.331445443808084 3229 2858827 SGTC_561 1550-0330 72.9 µM -0.435962480939201 0.322740071552233 no 2283 0.331431975682542 3169 6812934 SGTC_2706 st078239 82.5 µM -0.436164190115284 0.322662941844654 no 2284 0.331358803686007 3236 15434492 SGTC_1320 1313-0481 95.3 µM -0.436406419230083 0.32257032817494 no 2285 0.331270941188431 3332 6813365 YLR208W SEC13 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.4367603035263 0.322435044149259 no 2286 0.331142595288839 3190 6312947 SGTC_2277 7947813 106.88 µM -0.437067941399946 0.322317458455852 no 2287 0.331031038046348 3348 1246798 SGTC_1597 7-benzyloxygramine 47.5 µM -0.437147894560734 0.322286901578916 no 2288 0.331002047471449 3202 260807 SGTC_1492 4158-0558 28.5 µM -0.438576638625153 0.321741060050483 no 2289 0.33048416373166 3252 3967268 SGTC_290 2043-6722 48.1 µM -0.439360870316164 0.32144161327015 no 2290 0.330200037344793 3263 773758 YLR208W SEC13 SGTC_1782 st039423 80.636 µM -0.439385488363244 0.321432215125404 no 2291 0.33019111983384 3191 2068169 SGTC_1859 st055998 20 µM -0.439484324229181 0.321394484860242 no 2292 0.330155319024426 3335 676301 SGTC_199 4063-0024 41.6 µM -0.44096199482475 0.320830608915306 no 2293 0.329620255550193 3285 306215 SGTC_2951 9072950 58.06 µM -0.440996355307955 0.320817501937714 no 2294 0.329607817786418 3268 16488155 SGTC_821 1114-0266 29.2 µM -0.441674055765233 0.320559035380306 no 2295 0.329362543172381 3253 3123235 SGTC_3115 9123671 49.47 µM -0.441989741719548 0.320438666359605 no 2296 0.329248314578052 3303 3286988 SGTC_19 0279-0214 38.434 µM -0.442423314105382 0.320273378785004 no 2297 0.329091455640252 3206 3566274 YBR002C RER2 SGTC_3349 9149703 23.001 µM -0.444216410790477 0.319590188785432 no 2298 0.328443064254272 3218 4910494 SGTC_1627 st003713 25.6 µM -0.444730498030274 0.319394428511851 no 2299 0.328257263272497 3248 16195070 YER133W GLC7 SGTC_398 bronopol 33.3 µM -0.445258053172833 0.319193592092732 no 2300 0.328066638891452 3132 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_703 3875-0075 71.8 µM -0.446720208837383 0.318637237444875 no 2301 0.327538544335303 3198 2850814 SGTC_765 1319-0117 244 µM -0.447150822882028 0.318473465330705 no 2302 0.327383082855317 3178 3487746 YGL099W LSG1 SGTC_930 2810-3379 265 µM -0.448418730730922 0.317991457758806 no 2303 0.326925513134627 3380 1015764 SGTC_526 4469-0568 170 µM -0.449900389012122 0.317428581338236 no 2304 0.326391133539647 3194 2901964 SGTC_1817 st052116 64.4 µM -0.451258283640966 0.316913092712037 no 2305 0.325901703637566 3315 4361398 SGTC_1418 3966-3099 2.4 µM -0.451391988413119 0.316862354440476 no 2306 0.325853528240643 3287 740335 SGTC_126 0417-1624 672.48 µM -0.451586270043502 0.316788634608289 no 2307 0.325783531473451 3337 41912 YDL195W SEC31 SGTC_3272 9137413 49.47 µM -0.451594283728216 0.316785593985539 no 2308 0.325780644394501 3213 17614870 SGTC_2797 7859098 81.82 µM -0.453465677219831 0.316075872691406 no 2309 0.325106726507468 3173 972681 SGTC_954 1189-0853 2.85 µM -0.454859204327995 0.315547820754498 no 2310 0.324605266959891 3272 2828194 SGTC_985 1493-0307 8.71 µM -0.455656331082048 0.315245933126285 no 2311 0.324318564390905 3343 3278274 SGTC_88 0180-0332 8.668 µM -0.456825824860602 0.314803245988998 no 2312 0.323898121050343 3193 3101745 SGTC_3221 9128209 49.47 µM -0.456875030901389 0.314784625909864 no 2313 0.323880435963978 3226 16460723 SGTC_2704 st078022 71.1 µM -0.458770726700731 0.314067633732589 no 2314 0.323199409149296 3350 54697681 SGTC_691 1548-0686 185 µM -0.460862702051665 0.313277218354269 no 2315 0.32244855632456 3229 46495133 SGTC_2814 7977482 42.97 µM -0.461371495028598 0.313085109474335 no 2316 0.322266049388565 3330 6456762 SGTC_3156 9099931 49.47 µM -0.461421508045026 0.31306622841235 no 2317 0.322248111746724 3159 18111053 SGTC_2323 6148992 148.28 µM -0.461447334359414 0.31305647857762 no 2318 0.322238849056625 3196 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_441 propafenone 146 µM -0.461449115702137 0.313055806097899 no 2319 0.322238210176441 3194 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1018 4259-0013 28.1 µM -0.465379268731399 0.311573640479016 no 2320 0.32082993881352 3309 6801262 SGTC_402 epigallocatechin gallate 10 µM -0.466235797814305 0.311251024190214 no 2321 0.320523364131471 3217 65064 An antioxidant. SGTC_163 TUB2.036 7.546 µM -0.466346712849236 0.311209258039331 no 2322 0.320483673619889 3313 15992207 YJR013W GPI14 SGTC_2993 9054257 71.4286 µM -0.46744414692557 0.3107961394785 no 2323 0.320091071833356 3214 6470217 YGL055W OLE1 SGTC_3347 9188721 44.724 µM -0.469486966483412 0.310027774773823 no 2324 0.319360799436491 3287 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1850 st056238 17 µM -0.470566027149382 0.309622242537431 no 2325 0.318975336454251 3311 5393177 SGTC_1880 MG-132 525 µM -0.470997532881097 0.309460139002319 no 2326 0.31882124835495 3337 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_3174 9107204 49.47 µM -0.471328578748058 0.309335800298194 no 2327 0.318703055094244 3337 3938802 SGTC_3067 9117431 49.47 µM -0.473058764892922 0.308686308914227 no 2328 0.318085627245268 3234 17150885 SGTC_1351 1496-0003 46.5 µM -0.474010840280785 0.308329166015755 no 2329 0.317746088503917 3352 3891978 SGTC_971 1315-0384 26.7 µM -0.476987121515831 0.307213872875936 no 2330 0.316685646130724 3250 6769120 SGTC_1394 3474-0001 65.7 µM -0.477100694603966 0.307171349177517 no 2331 0.31664521004492 3268 5017666 YIL048W NEO1 SGTC_1982 st072467 71.9 µM -0.477224446596288 0.307125017275956 no 2332 0.31660115239914 3177 3163533 SGTC_2864 9034755 47.6 µM -0.477712745630343 0.306942231499699 no 2333 0.316427335694585 3345 4930451 SGTC_3338 9144300 39.5675 µM -0.477724919507114 0.306937675045306 no 2334 0.316423002754856 3260 4901274 SGTC_1416 3966-0321 25.3 µM -0.478164509755714 0.306773164621197 no 2335 0.316266560193064 3277 582530 YLR208W SEC13 SGTC_2432 5630864 12.22 µM -0.480425884534417 0.305927492660378 no 2336 0.315462296190928 3362 5714970 SGTC_1959 st077091 55.8 µM -0.480761849018057 0.305801942233254 no 2337 0.315342883954099 3215 821356 YKL052C ASK1 SGTC_558 k064-0027 21.3 µM -0.481405266101578 0.305561560023474 no 2338 0.315114247335413 3313 5088526 SGTC_2656 pseudo-anisatin 100 µM -0.481903848172924 0.305375346142625 no 2339 0.314937126158247 3269 6708809 A neurotoxin. SGTC_2643 anethole 100 µM -0.48580561139859 0.303919830357227 no 2340 0.313552497701576 3321 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1282 0886-0010 32.4 µM -0.490157292676361 0.3023001368328 no 2341 0.312011299467528 3424 2836211 YNL267W PIK1 SGTC_3009 9080819 71.4286 µM -0.490614630141487 0.302130141173107 no 2342 0.311849518427098 3312 17027216 SGTC_2249 haloperidol 116.36 µM -0.490644643481845 0.302118986497125 no 2343 0.311838902613822 3325 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2750 bromebric acid 70.15 µM -0.491388174807255 0.301842706727052 no 2344 0.311575963160633 3378 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2722 naftopidil 47.16 µM -0.492375000884305 0.301476199478737 no 2345 0.311227134276722 3352 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1690 st023502 41.2 µM -0.493538448535844 0.301044352408893 no 2346 0.310816089872808 3348 24207482 SGTC_1732 st034308 51.822 µM -0.493833586865382 0.300934847678997 no 2347 0.310711855423511 3174 830119 SGTC_1676 st018489 23.4 µM -0.493969298034586 0.300884500997302 no 2348 0.310663931203179 3276 3696235 SGTC_1391 3442-0225 151 µM -0.494228001194327 0.300788536771224 no 2349 0.310572583235957 3256 5227075 SGTC_3231 9132313 49.47 µM -0.495452642839597 0.300334451574719 no 2350 0.310140321405715 3314 4905967 SGTC_1324 1418-0026 34.4 µM -0.495899515795871 0.300168832615036 no 2351 0.30998265390137 3341 1372513 SGTC_2450 5739737 12.93 µM -0.496492468085901 0.299949137870049 no 2352 0.309773500038929 3355 2262825 SGTC_3113 9123498 49.47 µM -0.496882936233571 0.299804505271239 no 2353 0.309635802639035 3372 8897275 SGTC_710 3448-4187 58 µM -0.497115746716451 0.299718285391918 no 2354 0.309553715443968 3356 3946412 SGTC_318 1488-0629 67.2 µM -0.498702467978493 0.299130952640217 no 2355 0.308994502848291 3360 3662576 SGTC_1710 st031758 61.5 µM -0.498809212242544 0.299091459482309 no 2356 0.308956898537574 3422 5394341 SGTC_2343 7990716 14.84 µM -0.49917102408067 0.298957614238758 no 2357 0.308829452863743 3262 6456862 SGTC_1048 3161-0300 24.5 µM -0.499514060988764 0.298830739544544 no 2358 0.308708641781602 3368 2165101 SGTC_653 0203-0016 55.2 µM -0.500124617924049 0.298604981173734 no 2359 0.308493666442782 3315 295302 SGTC_2924 9010168 62.78 µM -0.500899935318336 0.298318413128158 no 2360 0.308220774019114 3342 2993929 SGTC_1529 apigenin 74 µM -0.500955331439832 0.298297942747705 no 2361 0.308201280017631 3461 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_963 1269-2853 151 µM -0.501045792623388 0.298264516243675 no 2362 0.308169447716513 3269 3668223 SGTC_1740 st038286 13.222 µM -0.502347543751488 0.297783692403339 no 2363 0.307711535591386 3426 716786 SGTC_1812 st052057 4.327 µM -0.502584062722674 0.29769636808198 no 2364 0.307628368316107 3294 3645418 SGTC_2883 9059145 45.46 µM -0.502845859412094 0.297599724691115 no 2365 0.307536324151995 3244 16476510 SGTC_2996 9066192 71.4286 µM -0.503204911232126 0.297467202437322 no 2366 0.307410106108256 3307 6472854 SGTC_1637 st007924 17.4 µM -0.505573332563028 0.296593718979884 no 2367 0.306578103141635 3314 683336 SGTC_1371 2421-0008 32.7 µM -0.506197138037147 0.296363852608092 no 2368 0.306359131966962 3265 2827552 SGTC_3145 9085516 49.47 µM -0.506629042242201 0.296204747892346 no 2369 0.306207563391147 3337 25236195 SGTC_2124 5246320 200 µM -0.506743487364145 0.296162595207224 no 2370 0.306167406606658 3359 579342 SGTC_989 1501-0895 10.3 µM -0.508905674723336 0.295366731203345 no 2371 0.305409171068106 3410 2830112 SGTC_2216 7189485 200 µM -0.508998515577004 0.295332580124332 no 2372 0.305376632303835 3369 731273 SGTC_190 3970-0790 3.722 µM -0.509182899640676 0.295264760686722 no 2373 0.305312014131531 3362 2832352 SGTC_2087 5276107 200 µM -0.509819957778401 0.295030495597182 no 2374 0.305088801120766 3331 144405 SGTC_331 k048-0133 24.5 µM -0.512432757827791 0.294070588758204 no 2375 0.304174084858814 3306 6813582 SGTC_586 0957-0265 8.15 µM -0.513056173077542 0.293841768046947 no 2376 0.303956013827661 3335 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_332 4112-0506 40.9 µM -0.513278662379406 0.293760124672107 no 2377 0.303878203817758 3329 2790355 SGTC_2804 7954240 19.48 µM -0.513556074654578 0.293658341789485 no 2378 0.303781198332593 3401 828705 SGTC_832 4083-0019 164 µM -0.513645977804336 0.293625359723254 no 2379 0.303749763976541 3409 1990758 SGTC_921 1561-0023 372 µM -0.514546087787706 0.293295237982318 no 2380 0.303435123376217 3346 24050882 SGTC_307 1501-1223 22.3 µM -0.515853879100883 0.292815902992598 no 2381 0.302978234192193 3361 2830329 SGTC_472 calcifediol 10 µM -0.515917929966664 0.292792436252034 no 2382 0.30295586533072 3368 5283731 A vitamin D metabolite. SGTC_2661 dactinomycin 12.96 µM -0.517108365050268 0.292356447670622 no 2383 0.302540257274544 3331 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2381 9035592 200 µM -0.51790138902601 0.292066175790772 no 2384 0.302263536419614 3339 4749657 SGTC_578 3460-0051 92 µM -0.518835147876751 0.291724562569786 no 2385 0.301937852667671 3451 2876744 SGTC_188 3229-0966 278.469 µM -0.51895921555364 0.291679186754516 no 2386 0.301894591235685 3431 5722370 SGTC_358 0075-0058 9.45 µM -0.519222500029273 0.291582905468823 no 2387 0.301802795218641 3506 1069125 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.519361854803183 0.291531950403822 no 2388 0.301754213257348 3277 803109 SGTC_679 0422-0091 41.4 µM -0.519537099902854 0.291467877938509 no 2389 0.301693124175949 3316 627384 YHR062C RPP1 SGTC_264 promethazine 12.5 mM -0.521024705548806 0.290924249785202 no 2390 0.301174780521398 3467 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_838 0109-0203 71.4 µM -0.521130032834629 0.290885777125012 no 2391 0.30113809533019 3368 759422 SGTC_346 4513-0042 7.16 µM -0.522181649383928 0.290501785980415 no 2392 0.300771930768315 3350 2827372 SGTC_1001 4048-4355 44.4 µM -0.522185363986797 0.290500430037196 no 2393 0.300770637729094 3355 21824233 SGTC_693 4161-2696 114 µM -0.523041616936613 0.290187950689893 no 2394 0.300472646262949 3381 805759 SGTC_374 0880-0231 82.3 µM -0.523161235397991 0.290144309892479 no 2395 0.300431027499739 3367 6833587 SGTC_1750 st081859 2.357 µM -0.524657716683529 0.289598603780098 no 2396 0.29991057810902 3436 5291695 SGTC_1915 st067105 30.6 µM -0.525041971076262 0.289458559554252 no 2397 0.299777007185733 3411 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_3181 9108277 49.47 µM -0.525391484412884 0.289331204583763 no 2398 0.299655536024603 3308 17097298 SGTC_1365 1672-3266 55.4 µM -0.526569337767307 0.288902214731559 no 2399 0.299246344796106 3424 6415873 SGTC_3146 9095609 49.47 µM -0.532115638413586 0.286886212443896 no 2400 0.297322953429532 3358 17173999 SGTC_3329 9141233 27.5565 µM -0.5326895494868 0.286677984997358 no 2401 0.297124250745875 3456 4909101 YNL103W MET4 SGTC_1451 4152-0210 104 µM -0.533984305929761 0.286208482533571 no 2402 0.296676196119391 3448 659563 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.53487264715966 0.285886565064988 no 2403 0.296368961870566 3325 4174840 SGTC_2896 9052656 71.43 µM -0.536121113421322 0.285434436529219 no 2404 0.29593742452616 3382 6469436 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.536781951196811 0.285195253880747 no 2405 0.295709120150997 3363 5379071 SGTC_2278 7948257 134.34 µM -0.537146527502011 0.285063340565779 no 2406 0.295583202007968 3426 1247028 SGTC_3299 9121982 43.1275 µM -0.537261178697198 0.285021862755162 no 2407 0.295543608628845 3360 17594604 YPL160W CDC60 SGTC_2961 9083290 32.55 µM -0.537811440637896 0.284822832404003 no 2408 0.295353616387484 3414 17741490 SGTC_278 4092-0821 23.9 µM -0.540025096898624 0.284022821209925 no 2409 0.294589862411913 3417 877900 SGTC_813 k007-0158 173 µM -0.540459865312774 0.283865823122288 no 2410 0.294439966070182 3384 6523916 SGTC_616 4092-0450 108 µM -0.54185274766678 0.283363122929228 no 2411 0.293959975311635 3404 787165 SGTC_1749 st037932 54.2 µM -0.543669483043741 0.282708093597618 no 2412 0.293334468026918 3431 594497 SGTC_1220 1838-0075 193 µM -0.545713103975996 0.281972130688559 no 2413 0.292631581460719 3406 5529645 SGTC_1310 1188-0297 994 nM -0.546557883647057 0.281668172609941 no 2414 0.292341255206208 3396 1588352 SGTC_1929 genistein trimethyl ether 50.5 µM -0.548658226048189 0.28091313903894 no 2415 0.291620009614479 3490 136420 SGTC_2055 5235184 200 µM -0.548771548264473 0.280872429665794 no 2416 0.291581119010237 3458 2836034 SGTC_2521 angolensin 13.4 µM -0.548844123541999 0.280846359541409 no 2417 0.291556213457498 3464 821428 A flavenoid. SGTC_3109 9122853 49.47 µM -0.549258716530924 0.280697453977839 no 2418 0.291413957205863 3414 1234709 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.549976303591061 0.280439815096383 no 2419 0.291167813379134 3362 115019 SGTC_674 0498-0004 451 µM -0.550414501853409 0.280282542894846 no 2420 0.291017552131158 3393 4231473 SGTC_922 1866-0035 480 µM -0.551173754176645 0.28001014348353 no 2421 0.290757285000765 3392 3156169 SGTC_2869 9037858 32.47 µM -0.551323768533579 0.279956337535518 no 2422 0.290705873861299 3416 27187042 SGTC_1301 naphtanilide LB 4.81 µM -0.551645975165016 0.279840787991663 no 2423 0.290595465404305 3482 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2982 9019404 25.97 µM -0.552714708242615 0.279457685298537 no 2424 0.290229390102406 3340 22333232 SGTC_2516 gossypol 71.55 µM -0.554240100323218 0.278911328248909 no 2425 0.289707269009854 3491 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1805 st050013 60.3 µM -0.555431600289065 0.278484924767557 no 2426 0.289299741563538 3389 4037144 SGTC_2908 7930301 100 µM -0.555607377883739 0.278422045928052 no 2427 0.289239643354353 3357 2223178 SGTC_3285 9112818 20.8695 µM -0.557323764063816 0.277808427257032 no 2428 0.288653121037887 3453 17017947 YPR165W RHO1 SGTC_349 k015-0014 24 µM -0.557647368144874 0.277692810821484 no 2429 0.288542602067701 3358 2196908 SGTC_2181 6316240 54.2555 µM -0.557694714280998 0.277675897086491 no 2430 0.288526433838027 3424 12779990 SGTC_3008 9078912 71.4286 µM -0.55873570332586 0.277304145743134 no 2431 0.288171054466545 3428 16648731 SGTC_420 mitomycin C 81.9 mM -0.560844244850739 0.276551903513298 no 2432 0.287451860784024 3412 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_726 3448-4391 34.2 µM -0.561337749593003 0.276375985581627 no 2433 0.287283655968893 3553 1356692 SGTC_2280 7785178 200 µM -0.562016525890781 0.276134114239889 no 2434 0.287052379815664 3393 2954328 SGTC_1885 st057546 99.9 µM -0.563014154944992 0.275778813386516 no 2435 0.286712622630091 3523 702008 SGTC_2659 sanguinarine 24.21 µM -0.563143335821535 0.275732822664933 no 2436 0.286668642137052 3388 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2457 5731572 11.68 µM -0.563229955640529 0.275701986558804 no 2437 0.286639153632425 3473 2865357 SGTC_3070 9117005 49.47 µM -0.563697998312488 0.275535395668339 no 2438 0.286479839949857 3489 8779016 SGTC_828 2074-0507 139 µM -0.563808022422756 0.275496241866036 no 2439 0.286442395733407 3489 X828 SGTC_785 1270-0111 65.3 µM -0.564393909506821 0.275287790873678 no 2440 0.286243041444342 3456 6741994 SGTC_2958 9077254 16.72 µM -0.564776824419283 0.275151596697186 no 2441 0.286112786199391 3519 16457351 SGTC_2397 5161689 200 µM -0.564968047332487 0.275083595454557 no 2442 0.286047748905097 3531 2259942 SGTC_1631 benzylvanillin 81.9 µM -0.568618676227931 0.273786976172495 no 2443 0.284807473835563 3461 75506 SGTC_1981 st071826 47 µM -0.573735623773101 0.271974656574232 no 2444 0.283073358930446 3436 11838600 SGTC_2018 5133068 143 µM -0.574622392005027 0.271661188833271 no 2445 0.282773352373137 3461 785362 SGTC_1941 st076221 61.8 µM -0.575134479054878 0.271480250811076 no 2446 0.282600175496329 3442 2828568 SGTC_89 0302-0250 142.109 µM -0.575146794634846 0.271475900031103 no 2447 0.282596011258704 3532 4203518 YLR208W SEC13 SGTC_2047 4141938 200 µM -0.575668735468373 0.271291543594525 no 2448 0.282419555771594 3420 3807862 SGTC_2342 7990637 118.86 µM -0.577417031527503 0.270674477119521 no 2449 0.281828885795351 3483 2033102 YER133W GLC7 SGTC_1167 k781-0610 148 µM -0.577612093559436 0.270605672862648 no 2450 0.281763020113082 3457 4525169 SGTC_2870 9038528 12.99 µM -0.578209627140727 0.270394959144035 no 2451 0.281561299938867 3479 6463316 SGTC_557 1315-0110 16.2 µM -0.578622004262095 0.270249586679418 no 2452 0.281422127002276 3469 6833801 SGTC_2900 5328528 85.29 µM -0.578916572452824 0.270145768518976 no 2453 0.281322733668819 3495 795359 SGTC_1032 k061-1018 98.7 µM -0.579463537036726 0.269953048230525 no 2454 0.281138221585605 3565 4005393 SGTC_1042 0350-0096 82 µM -0.579469857355222 0.269950821699516 no 2455 0.281136089841993 3441 3122515 SGTC_1615 st002656 86.5 µM -0.579499237874129 0.269940471608179 no 2456 0.281126180359475 3520 1584458 SGTC_753 1322-0200 289 µM -0.579597569276115 0.26990583312728 no 2457 0.281093016300878 3529 5403907 SGTC_1452 4194-0072 190 µM -0.579988553900506 0.269768125859494 no 2458 0.280961168306559 3527 1343545 SGTC_2241 6772625 37.8075 µM -0.582480666194118 0.268891215753982 no 2459 0.280121480301732 3470 2285411 SGTC_2998 9066762 71.4286 µM -0.583062178068841 0.268686802857077 no 2460 0.279925721835363 3554 4945196 SGTC_3138 9097216 49.47 µM -0.583431998813519 0.268556844197404 no 2461 0.279801260974694 3510 25237486 SGTC_2005 4024620 188 µM -0.585295022404607 0.267902640180278 no 2462 0.279174680605604 3501 236743 SGTC_446 go6976 132 µM -0.586146359972244 0.267603958908706 no 2463 0.278888582206472 3478 3501 A protein kinase C inhibitor. SGTC_1898 st060199 18.6 µM -0.586777999262209 0.267382464590754 no 2464 0.27867640729273 3501 688866 SGTC_1250 0485-0349 40.2 µM -0.588343860893808 0.266833769514754 no 2465 0.278150755505835 3434 6842794 YDL195W SEC31 SGTC_1764 st044502 93.5 µM -0.589259365213538 0.266513230536092 no 2466 0.277843649539037 3507 8407 SGTC_2069 5228469 200 µM -0.590349012483662 0.266131974138743 no 2467 0.27747834320921 3469 2835210 SGTC_1162 k048-0130 20.1 µM -0.591191594223164 0.265837352893011 no 2468 0.277196027113609 3460 6797406 SGTC_2026 5148700 152 µM -0.591497404345842 0.265730462731892 no 2469 0.277093596902334 3458 79838 SGTC_1833 st055984 71 µM -0.593216399711904 0.265130026078053 no 2470 0.276518169342472 3450 676288 SGTC_2196 6573537 42.6665 µM -0.595070917656327 0.264483025648404 no 2471 0.275898033779845 3557 2903087 SGTC_13 0199-0087 65 µM -0.59525872410905 0.264417548948469 no 2472 0.275835270963006 3526 4589825 SGTC_2701 st077767 14.721 µM -0.595508767699598 0.264330386746189 no 2473 0.27575172007967 3498 5721188 SGTC_2110 5483698 200 µM -0.596764312204526 0.263892940208042 no 2474 0.275332373950323 3478 2848765 YHR062C RPP1 SGTC_138 0850-0259 40.9225 µM -0.59746884797942 0.263647633368769 no 2475 0.275097199763765 3548 6813004 SGTC_448 monastrol 171 µM -0.599011797349003 0.263110812464985 no 2476 0.274582508774301 3470 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2139 5578692 56.4705 µM -0.599102951366875 0.263079115760912 no 2477 0.274552116842326 3466 650991 YMR113W FOL3 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.599462593619124 0.262954077515011 no 2478 0.274432223643555 3514 229346 A bile salt which induces apoptosis. SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.600590070764361 0.262562280082642 no 2479 0.274056526468234 3486 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1659 st012954 42.1 µM -0.603326028137401 0.261612780765056 no 2480 0.273145910535365 3534 24207262 SGTC_3192 9110362 49.47 µM -0.603520940351035 0.261545204836047 no 2481 0.273081094645592 3586 16649480 SGTC_731 3966-0296 387 µM -0.604977461382624 0.261040513824271 no 2482 0.272596986231152 3538 660956 SGTC_2462 5162487 171.77 µM -0.605299153352887 0.260929113667559 no 2483 0.272490121936831 3510 2259986 SGTC_170 4197-0004 226 µM -0.605416924279119 0.260888336359419 no 2484 0.272451004288723 3533 218692 SGTC_3193 9111931 49.47 µM -0.607511604613973 0.260163616836041 no 2485 0.271755721860119 3513 17087244 SGTC_591 4299-0174 154 µM -0.607608252888055 0.260130203434023 no 2486 0.271723662945846 3451 5509088 SGTC_296 1222-0039 74.9 µM -0.607698243618075 0.260099093678142 no 2487 0.271693814078425 3488 5984176 SGTC_1621 st003705 32.4 µM -0.608061132473609 0.259973662624999 no 2488 0.27157346467466 3558 24207032 SGTC_2384 9036245 200 µM -0.608834582107282 0.259706427051158 no 2489 0.271317044448624 3469 6462766 SGTC_96 0929-0093 37.281 µM -0.608844173440903 0.259703114027404 no 2490 0.271313865410368 3482 6991579 SGTC_1037 k284-1091 78.7 µM -0.60949593742776 0.259478033826352 no 2491 0.271097882369416 3533 3334711 SGTC_2570 licareol 100 µM -0.611252662759764 0.258871868362577 no 2492 0.270516162073416 3483 443158 SGTC_1202 1988-0068 29.6 µM -0.611270307217787 0.258865783786562 no 2493 0.270510322469883 3445 2850480 SGTC_657 3534-0529 86.7 µM -0.611994838119004 0.258615997958408 no 2494 0.270270586386966 3544 1049549 SGTC_524 r073-0010 27.8 µM -0.612172261896312 0.258554849207979 no 2495 0.27021189579605 3488 2772106 SGTC_1883 5-benzylidenerhodanine 20 µM -0.61228591097816 0.258515684213446 no 2496 0.270174304794142 3520 1273210 SGTC_975 1335-0046 28.5 µM -0.612418837281102 0.258469879929433 no 2497 0.270130340904249 3482 16486740 SGTC_136 0097-0015 404.482 µM -0.612992336179251 0.25827230956065 no 2498 0.26994070358432 3565 4861337 SGTC_493 zm226600 134 µM -0.613271043985367 0.25817632299209 no 2499 0.269848568097807 3578 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1642 st009582 77.7 µM -0.61460767379093 0.257716246765717 no 2500 0.269406922693861 3559 6739311 SGTC_1373 2887-0003 58.5 µM -0.614765548857093 0.257661933311845 no 2501 0.269354782003401 3503 776948 SGTC_1429 4049-0205 9.46 µM -0.615472094115963 0.257418934747052 no 2502 0.269121496478444 3570 22774478 SGTC_108 0509-0257 621.132 µM -0.618232180233956 0.256470814531295 no 2503 0.268211150110703 3525 536624 SGTC_2966 9084041 48.03 µM -0.618396470759027 0.256414436338315 no 2504 0.268157011830472 3434 17741380 SGTC_2317 5986382 200 µM -0.618455510307821 0.256394177812059 no 2505 0.268137558006583 3597 877883 SGTC_2421 5690543 90.72 µM -0.618747838224536 0.256293882208904 no 2506 0.268041244975858 3558 3397993 SGTC_1939 st074455 53.6 µM -0.61883670298998 0.256263397401649 no 2507 0.268011970229239 3577 1644229 SGTC_723 4182-0001 115 µM -0.620430768849789 0.255716878843792 no 2508 0.267487110211562 3477 744821 YLR208W SEC13 SGTC_481 bay k-8644 50 µM -0.620555953954681 0.255673985460742 no 2509 0.267445913891162 3487 2303 A calcium channel antagonist. SGTC_809 3998-0021 90 µM -0.620718855548183 0.255618174538499 no 2510 0.267392310498089 3511 715485 SGTC_3083 9117465 49.47 µM -0.622256172139049 0.255091795501604 no 2511 0.266886717626662 3552 16420915 SGTC_797 k781-0471 270 µM -0.622495294359568 0.255009970750614 no 2512 0.266808118507498 3504 23738129 SGTC_118 0083-0097 135.343 µM -0.624848895778856 0.254205329937133 no 2513 0.266035117897627 3635 5207356 SGTC_1287 0971-0001 34.6 µM -0.625911021441851 0.253842650682053 no 2514 0.265686652507814 3556 4665869 SGTC_2056 5235370 200 µM -0.62830697161684 0.253025514912258 no 2515 0.264901432739022 3527 5511916 SGTC_649 1123-0311 367 µM -0.628358747971473 0.253007871941726 no 2516 0.264884477210516 3549 693629 YIL048W NEO1 SGTC_2504 purpurogallin 52.29 µM -0.62957063641638 0.252595101751603 no 2517 0.264487770097418 3495 5281571 An antioxidant. SGTC_804 1595-0054 20.9 µM -0.629652678436653 0.252567170998904 no 2518 0.264460924882079 3528 761523 Stimulates phospholipase C. SGTC_1236 0330-0013 258 µM -0.629708893664023 0.252548033774643 no 2519 0.264442531329675 3515 4617066 SGTC_76 0433-0009 400.328 µM -0.634054431500327 0.251071007119371 no 2520 0.263022649981862 3544 2841569 SGTC_867 0518-0118 155 µM -0.636945323670084 0.250090944627585 no 2521 0.262080229397897 3605 6848158 SGTC_2933 9026794 32.47 µM -0.637496070618962 0.24990446229904 no 2522 0.261900884313346 3546 17586027 SGTC_1931 st074438 57.1 µM -0.63888229699524 0.249435414392088 no 2523 0.261449752665397 3551 2787313 SGTC_1230 0170-0365 3.77 µM -0.639404889837772 0.249258709756219 no 2524 0.261279784382122 3650 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_778 3456-2434 196 µM -0.640041255758443 0.249043624869246 no 2525 0.261072889179664 3603 5539063 SGTC_1044 1222-0021 1.78 µM -0.640984896197963 0.248724866342201 no 2526 0.260766248036863 3541 4306703 SGTC_1737 st035557 69.7 µM -0.64109018489805 0.248689313655777 no 2527 0.260732045391047 3500 5716916 SGTC_2406 ethylparaben 405.7 µM -0.641425250623923 0.248576190499546 no 2528 0.260623215890439 3389 8434 A possible steroid mimic. SGTC_1337 1486-1011 40.3 µM -0.642015747123499 0.24837689687176 no 2529 0.260431479288237 3613 X1337 SGTC_900 1112-0045 141 µM -0.642306243360978 0.248278885135128 no 2530 0.260337180652982 3522 56211 YIL048W NEO1 SGTC_2250 alverine citrate 130 µM -0.642678606443738 0.248153282165704 no 2531 0.260216332767184 3529 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1266 0828-0227 32.9 µM -0.642702013901958 0.248145387654254 no 2532 0.260208737002996 3534 3913820 SGTC_2108 5365811 200 µM -0.642922848976576 0.248070914353369 no 2533 0.26013708123103 3592 780283 SGTC_1609 st001574 46.4 µM -0.643757706715363 0.247789478941132 no 2534 0.259866281531669 3552 3960012 SGTC_343 4130-2827 29.8 µM -0.644658994709007 0.247485840959109 no 2535 0.259574097429127 3575 1118244 SGTC_787 4152-0075 138 µM -0.645122484149714 0.247329771866852 no 2536 0.259423907147889 3569 9566539 SGTC_2663 amphotericin b 100 µM -0.645875390540357 0.247076360662035 no 2537 0.259180029192136 3573 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2086 5274770 176.623 µM -0.647728931270542 0.246453093243898 no 2538 0.258580144256462 3571 689278 SGTC_1178 0988-0033 191 µM -0.647863537019978 0.246407863854793 no 2539 0.258536608106912 3596 5392207 SGTC_2233 sulbentine 40.3845 µM -0.647947578172794 0.246379627123756 no 2540 0.258509428219831 3568 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2490 carminic acid 95.39 µM -0.647956800324027 0.246376528706842 no 2541 0.258506445758887 3558 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3286 9117135 37.221 µM -0.649999686237849 0.245690684086765 no 2542 0.257846212142377 3526 3438150 SGTC_2592 piperlongumine 83.33 µM -0.650915836533057 0.245383444288581 no 2543 0.257550408984511 3543 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1068 loratadine 26.9 µM -0.651341730121537 0.245240687121755 no 2544 0.257412958101481 3578 3957 A H1 histamine antagonist. SGTC_1085 doxorubicin 7.67 µM -0.651506737352296 0.245185389617568 no 2545 0.257359714693895 3617 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_400 oxethazaine 37.5 µM -0.652754147368303 0.244767572460422 no 2546 0.256957394181214 3562 4621 A local anesthetic. SGTC_2762 leflunomide 42.06 µM -0.65472037145645 0.244109769154758 no 2547 0.256323903399462 3595 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_3291 9121177 71.43 µM -0.654775723908948 0.244091264713702 no 2548 0.256306081376621 3546 17015612 SGTC_581 0958-0271 211 µM -0.655189437639982 0.243952983305835 no 2549 0.256172896976387 3609 4591145 SGTC_1131 3454-3128 32.3 µM -0.657088098263859 0.243318909470359 no 2550 0.255562135609318 3609 710982 SGTC_2040 5100729 123 µM -0.658070499600243 0.242991178197039 no 2551 0.255246415498925 3614 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2710 st078562 53.7235 µM -0.658440986593369 0.242867644944573 no 2552 0.255127402884657 3582 17250908 SGTC_929 2805-0021 398 µM -0.658511335820125 0.242844191904607 no 2553 0.255104807677042 3623 3098024 SGTC_2210 7115885 190.385 µM -0.659001561335902 0.242680794451428 no 2554 0.254947383023536 3612 2927039 SGTC_3264 9137442 49.47 µM -0.659383741235035 0.242553451068101 no 2555 0.254824690008186 3658 17015726 SGTC_1964 st076914 61 µM -0.661564864655161 0.241827387896899 no 2556 0.25412506565269 3628 24208661 SGTC_1699 st031318 29.054 µM -0.66184865038217 0.241733006678799 no 2557 0.254034111731341 3635 5340658 SGTC_1778 st046819 58.9 µM -0.663255594410296 0.241265381823692 no 2558 0.25358343556882 3650 671715 SGTC_868 0527-0199 213 µM -0.663477655164846 0.241191620613581 no 2559 0.253512342855986 3562 2849450 SGTC_205 1486-1330 71.903 µM -0.664066821508698 0.240995978531428 no 2560 0.253323772113592 3610 4118834 SGTC_2875 9039966 71.43 µM -0.664101313903718 0.240984527456283 no 2561 0.253312734636309 3636 6463691 SGTC_1973 st070275 50.2 µM -0.664161071011874 0.240964689489798 no 2562 0.253293613114537 3564 17118334 SGTC_3275 9138069 49.47 µM -0.664959360735062 0.24069976112181 no 2563 0.25303824325984 3630 17617007 SGTC_1021 4476-0760 85.3 µM -0.666445811683154 0.240206875434893 no 2564 0.252563094424494 3598 746768 SGTC_861 0443-0273 110 µM -0.666609941298004 0.240152486163062 no 2565 0.252510658695436 3620 6149169 SGTC_347 4534-1311 26.2 µM -0.667144326776876 0.239975448018134 no 2566 0.25233997427562 3635 2862016 SGTC_1356 1502-0781 85.8 µM -0.668114341916887 0.239654270758918 no 2567 0.252030303827741 3601 567702 SGTC_530 4358-1714 28 µM -0.668611857608728 0.23948963168935 no 2568 0.251871553303192 3628 1564641 SGTC_722 3534-0461 190 µM -0.669289389867352 0.239265520465666 no 2569 0.251655446843857 3597 658262 SGTC_209 4077-0173 175.592 µM -0.669838035154854 0.239084125914029 no 2570 0.251480522107499 3567 15993494 SGTC_1857 st056007 79.3 µM -0.671421887673229 0.23856089039998 no 2571 0.250975902649015 3642 619834 SGTC_2256 7954252 200 µM -0.671635737666499 0.238490291785362 no 2572 0.250907810576573 3579 2972920 SGTC_1614 st002383 48.6 µM -0.672185072561007 0.238308991483976 no 2573 0.250732941435766 3633 1947235 SGTC_378 3970-0959 8.33 µM -0.672946687589855 0.238057756026087 no 2574 0.250490604213022 3635 6615653 SGTC_2001 4023502 57.655 µM -0.673153358884384 0.237989606006675 no 2575 0.250424865178558 3628 108941 YCR052W RSC6 SGTC_245 methotrexate 289.6 µM -0.674077678219055 0.237684941909426 no 2576 0.250130965016108 3629 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2273 7815444 169.05 µM -0.676113692182019 0.237014608510149 no 2577 0.249484232028435 3609 2824616 SGTC_916 4466-0038 42 nM -0.678609287630705 0.23619438261971 no 2578 0.24869272823751 3688 5722064 YGL116W CDC20 SGTC_3074 9116018 49.47 µM -0.679146139078435 0.236018140524607 no 2579 0.248522635227003 3685 17027303 SGTC_2043 5101342 149 µM -0.679714684434972 0.235831572722463 no 2580 0.248342568099819 3636 678451 SGTC_1640 st009078 66.4 µM -0.681342301967597 0.235297920867109 no 2581 0.247827461185032 3648 690618 SGTC_2763 lisinopril 49.32 µM -0.681516894508661 0.235240716303747 no 2582 0.247772240189225 3618 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1914 st062367 72.6 µM -0.682805537765238 0.234818734969077 no 2583 0.247364864971261 3644 978205 SGTC_2727 riluzole 51.77 µM -0.683024977702765 0.234746918505178 no 2584 0.247295529723468 3641 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_140 0062-0056 502.533 µM -0.683098854971511 0.234722743304243 no 2585 0.247272189461244 3631 3758964 SGTC_1328 1441-0025 69.2 µM -0.683941216894127 0.234447190659502 no 2586 0.247006142885561 3593 4562601 SGTC_903 1134-0042 114 µM -0.68456201030638 0.234244231908524 no 2587 0.246810173259136 3648 701009 SGTC_3063 1327-0034 4 µM -0.686251380963006 0.233692411246512 no 2588 0.246277301080445 3584 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1947 st076332 61.6 µM -0.687902668420537 0.233153727381352 no 2589 0.245757038041495 3638 24208416 SGTC_2326 6164455 177.58 µM -0.688157251991889 0.233070738368323 no 2590 0.24567688017599 3644 2888790 SGTC_303 1348-1668 34.2 µM -0.688656143085865 0.232908157697377 no 2591 0.245519840671584 3673 5380509 SGTC_1942 st076330 65.2 µM -0.689174656270151 0.232739249284233 no 2592 0.24535668175046 3700 24208414 SGTC_2019 4016004 108 µM -0.689690491374356 0.232571280839869 no 2593 0.245194423375323 3637 45595336 SGTC_2321 7390090 138.78 µM -0.690748187610235 0.232227080116213 no 2594 0.244861900540588 3609 649046 SGTC_1124 fisetin 1.16336 µM -0.691427461770999 0.23200617693887 no 2595 0.244648475625835 3666 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_729 4092-0585 94.1 µM -0.69268214577959 0.231598455557869 no 2596 0.244254523048176 3654 2169061 SGTC_155 k072-0202 43.6 µM -0.692828786516988 0.231550829348797 no 2597 0.244208502314338 3606 5857737 SGTC_2654 protoveratrine a 100 µM -0.693913882093137 0.23119858002033 no 2598 0.2438681086145 3641 5702278 A heart drug and vasodilator. SGTC_3077 9117319 49.47 µM -0.697539028461303 0.230023936879171 no 2599 0.242732761764572 3670 17154678 SGTC_2620 irigenin 100 µM -0.697871842498669 0.229916263978647 no 2600 0.242628672492659 3692 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2031 5180455 200 µM -0.698233988850749 0.22979913346686 no 2601 0.242515436854031 3666 29949 SGTC_621 3584-0052 32.1 µM -0.69880051980355 0.229615965023847 no 2602 0.242338351826229 3679 2273927 SGTC_1719 st032227 49.2 µM -0.700162570118354 0.229175927417727 no 2603 0.241912891952684 3701 3125804 SGTC_1269 0831-0796 3.05 µM -0.701498807866354 0.228744689034203 no 2604 0.241495889169959 3667 927758 SGTC_2383 9036125 200 µM -0.701683715889978 0.228685050349928 no 2605 0.241438215263208 3635 79580 SGTC_1245 0418-0076 17.2 µM -0.701920227368887 0.228608780647201 no 2606 0.241364456839734 3688 6790114 SGTC_979 1426-2828 121 µM -0.702296976389252 0.228487316958458 no 2607 0.241246989250802 3760 747872 SGTC_2335 9018011 154.17 µM -0.703147881641653 0.228213119004486 no 2608 0.240981797585194 3712 6458208 SGTC_2603 homopterocarpin 100 µM -0.703379161540528 0.228138622745687 no 2609 0.240909744702179 3712 101795 A weak amylase inhibitor. SGTC_1247 0448-0043 5.84 µM -0.70370693836395 0.228033067834228 no 2610 0.240807649267152 3732 3089013 YGL099W LSG1 SGTC_2807 7945238 51.95 µM -0.704569653994243 0.227755376377132 no 2611 0.240539044453584 3710 17148797 SGTC_2655 perillic acid 100 µM -0.705818372211883 0.227353775486287 no 2612 0.240150547621956 3685 5702197 An apoptosis inducer. SGTC_322 k048-0136 19.3 µM -0.708527130630982 0.22648398322187 no 2613 0.239308985086832 3696 6823282 SGTC_1700 st030840 7.9285 µM -0.708920734949457 0.226357751959433 no 2614 0.239186833499326 3719 5499307 SGTC_2062 5245942 200 µM -0.710093505847584 0.225981872993512 no 2615 0.238823076602664 3764 1376160 SGTC_1974 st069448 26.9 µM -0.711908928927219 0.225400717259499 no 2616 0.238260586322292 3661 6323587 YNR016C ACC1 SGTC_913 3487-1245 167 µM -0.712484292709906 0.225216707749706 no 2617 0.238082467305582 3672 4016153 SGTC_261 5-fluorouridine 15.376 µM -0.713045544567818 0.225037293445139 no 2618 0.237908787345614 3732 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1565 sinapyl alcohol 95.1 µM -0.713450955431589 0.224907746929529 no 2619 0.23778337576646 3693 5280507 A phenol propionate derived from cinnamic acid. SGTC_1653 st012112 65 µM -0.716868042415856 0.223817519290028 no 2620 0.236727761222149 3708 720429 SGTC_2517 totarol 10 µM -0.717964679113305 0.223468273155426 no 2621 0.236389532772979 3672 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_3135 9127742 49.47 µM -0.718282246396503 0.223367195349223 no 2622 0.236291637278938 3739 3643468 SGTC_791 1348-1292 225 µM -0.718729202053678 0.223224978879871 no 2623 0.236153893454737 3707 5437054 SGTC_1770 st043884 66.3 µM -0.719310214454934 0.223040184073324 no 2624 0.235974901852319 3701 670149 SGTC_3339 9145883 14.936 µM -0.71965085348929 0.222931882117494 no 2625 0.235869996481719 3632 2030670 SGTC_1560 lithocholic acid 53.1 µM -0.720186008381598 0.222761796771603 no 2626 0.235705238699175 3642 9903 A bile acid which acts as a detergent. SGTC_752 1896-0090 130 µM -0.721563118341277 0.22232445762219 no 2627 0.235281560708453 3705 772567 SGTC_300 r073-0011 5.04 µM -0.7216528210591 0.22229598705921 no 2628 0.235253977601917 3727 2735780 SGTC_457 grayanotoxin iii 135 µM -0.722016149459822 0.222180692275128 no 2629 0.235142274322748 3662 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_485 niflumic acid 177 µM -0.722231373400007 0.222112411489164 no 2630 0.235076118747377 3730 4488 A COX2 inhibitor. SGTC_2013 4024628 200 µM -0.726078879465867 0.220893795080068 no 2631 0.2338952079379 3729 5230760 SGTC_432 NS 1619 61.3 µM -0.726486337298303 0.220764965927915 no 2632 0.233770340122804 3764 4552 A K+/calcium channel activator. SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.728711905227433 0.220062050406657 no 2633 0.233088954408279 3651 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2170 morpholine 200 µM -0.728768635579913 0.220044149688915 no 2634 0.233071600119625 3755 121171 Reacts with secondary amines. SGTC_602 3130-1533 38.1 µM -0.730333875428222 0.219550582876804 no 2635 0.23259306325462 3738 720941 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.730390964646056 0.219532592970979 no 2636 0.232575619841535 3696 390807 SGTC_658 3253-0951 102 µM -0.730422824302306 0.219522553751291 no 2637 0.232565885549952 3737 1184878 SGTC_2905 7799065 20.05 µM -0.730787404295857 0.21940769060264 no 2638 0.232454509141014 3648 1296806 SGTC_2106 5357045 167.29 µM -0.731135196461341 0.219298148752508 no 2639 0.232348288937723 3754 668842 SGTC_806 3966-4455 5.86 µM -0.731849762437274 0.219073185184744 no 2640 0.232130136043878 3715 714982 SGTC_177 1327-0068 8.361 µM -0.731942754697825 0.219043918614687 no 2641 0.232101754426227 3728 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2097 5376186 200 µM -0.733158582559522 0.218661479602065 no 2642 0.231730856575918 3672 742755 SGTC_2607 solasodine 47.35 µM -0.733803057057316 0.218458915920042 no 2643 0.231534388558878 3759 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_995 3931-2021 34.6 µM -0.733876231866185 0.218435923304135 no 2644 0.231512087093789 3735 730143 SGTC_961 1252-1571 372 µM -0.736388686014051 0.217647318610648 no 2645 0.230747094018084 3733 6813498 SGTC_1980 st071811 45.7 µM -0.73642768593788 0.217635090345589 no 2646 0.230735230444625 3804 4974850 SGTC_633 0437-0093 97.7 µM -0.736457435346987 0.217625762807773 no 2647 0.230726181058589 3704 2831118 SGTC_2014 4013930 200 µM -0.736579514507871 0.21758748890058 no 2648 0.230689048230646 3709 64556 SGTC_1353 1498-1206 8.11 µM -0.736639740708048 0.217568608386671 no 2649 0.230670730452503 3775 6756808 SGTC_781 4335-2806 94.4 µM -0.739560242611963 0.216654185669569 no 2650 0.229783436550249 3865 845254 SGTC_3171 9103192 49.47 µM -0.740545090287636 0.216346327212801 no 2651 0.229484655969848 3773 13018434 SGTC_1891 st059073 26.2 µM -0.744143643463191 0.215223592730597 no 2652 0.228394789140294 3754 688754 SGTC_1878 temozolomide 1 mM -0.744732306528914 0.215040254535211 no 2653 0.228216782387537 3675 5394 DNA alkylating agent. SGTC_2696 st077691 74.316 µM -0.745112205819929 0.21492198365416 no 2654 0.228101945463032 3732 757133 SGTC_3020 9089140 49.47 µM -0.746508903915644 0.214487486189213 no 2655 0.227680027470043 3790 17217859 SGTC_1692 fluoroquinolonic acid 71 µM -0.748081645287949 0.213998835457684 no 2656 0.227205456212723 3776 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2973 9094665 17.96 µM -0.748266084043263 0.213941572821692 no 2657 0.227149838770609 3793 25237061 YIL048W NEO1 SGTC_14 0354-0009 295 µM -0.748282042088514 0.213936618752281 no 2658 0.227145026988403 3806 1713507 SGTC_1724 st037281 8.293 µM -0.74867734528337 0.213813920814044 no 2659 0.227025850726418 3772 574124 YDL195W SEC31 SGTC_2695 st077686 51.995 µM -0.750496516985075 0.213249797607134 no 2660 0.226477860369327 3802 2876092 SGTC_2441 5730946 39.09 µM -0.752169936508139 0.212731639211521 no 2661 0.225974435221366 3810 1774275 SGTC_950 1165-0508 94.1 µM -0.753035861696818 0.212463802588274 no 2662 0.225714182176031 3779 6148369 SGTC_223 busulfan 5 mM -0.753402906753339 0.212350332502357 no 2663 0.2256039183013 3756 2478 A DNA alkylator. SGTC_2225 6654152 15.4 µM -0.753450764629368 0.21233554009702 no 2664 0.225589543580397 3682 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2597 laccaic acid a 100 µM -0.754652825356731 0.211964192340658 no 2665 0.225228659419893 3772 5491415 A textile dye. SGTC_632 0781-2353 4.65 µM -0.756818882893999 0.2112960007447 no 2666 0.224579189168076 3823 6811515 YHR007C ERG11 SGTC_3066 9117245 49.47 µM -0.757465748526279 0.211096693328569 no 2667 0.224385439334148 3839 17176980 SGTC_3154 9100113 49.47 µM -0.758011380758246 0.210928662894195 no 2668 0.224222084819375 3784 25237525 SGTC_428 3448-4153 16.5 µM -0.759096566002792 0.210594707335653 no 2669 0.223897396610548 3748 3834874 SGTC_202 3594-0513 34.79 µM -0.759728423717965 0.210400402063955 no 2670 0.223708467470258 3752 708429 SGTC_3015 9080845 49.47 µM -0.760602461880875 0.21013179640131 no 2671 0.223447274432425 3841 5296973 SGTC_2163 5671233 125 µM -0.761049453465594 0.209994506748514 no 2672 0.223313764862159 3793 701023 SGTC_789 1309-1135 70.6 µM -0.761074502059837 0.209986814846336 no 2673 0.22330628457256 3776 3092424 SGTC_812 4251-0442 148 µM -0.761762285818259 0.209775675455056 no 2674 0.223100946663888 3749 5723007 SGTC_3187 9109394 49.47 µM -0.762439414478654 0.209567928998378 no 2675 0.222898894903193 3738 17098090 SGTC_2135 5326629 150.42 µM -0.762477703833357 0.209556185249086 no 2676 0.222887472668677 3754 5020077 SGTC_247 mechlorethamine 29.705 µM -0.765564712811801 0.208610641328385 no 2677 0.221967673794525 3702 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_788 1182-0090 188 µM -0.768161206828452 0.207817291903847 no 2678 0.221195708718723 3895 5715185 SGTC_2404 5161160 200 µM -0.768361955905756 0.207756028043975 no 2679 0.221136087931392 3746 2831543 SGTC_941 3237-0776 460 µM -0.76867126244088 0.207661655905052 no 2680 0.22104424449178 3780 760008 SGTC_2464 5717415 7.67 µM -0.769201975311849 0.207499789772302 no 2681 0.220886708989773 3767 5285744 SGTC_2144 5628481 200 µM -0.769358486701803 0.207452068421884 no 2682 0.220840262810091 3775 2818399 SGTC_3097 9117246 49.47 µM -0.769492319975157 0.207411266924046 no 2683 0.220800551003553 3811 16423892 SGTC_1583 clindamycin 39.6 µM -0.77142782398836 0.206821724044275 no 2684 0.220226694090075 3763 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2306 7482397 179.52 µM -0.772796192284587 0.2064055264884 no 2685 0.219821503624037 3772 891448 SGTC_1837 st055472 66.5 µM -0.773245390511078 0.2062690083798 no 2686 0.21968858392674 3869 676091 SGTC_1154 4088-0362 150 µM -0.7736865204262 0.206134994452105 no 2687 0.219558096601744 3794 6618304 SGTC_2473 5854593 8.94 µM -0.773695116123486 0.206132383618253 no 2688 0.219555554415369 3715 2872951 SGTC_1438 4092-1045 4 µM -0.774164637833675 0.205989802150061 no 2689 0.219416718568908 3773 1351342 SGTC_1040 k898-0338 155 µM -0.774222576736256 0.205972211675401 no 2690 0.219399589745096 3775 20969351 SGTC_1136 pergolide 1.05886 µM -0.775190615385213 0.205678443222781 no 2691 0.219113516377127 3797 47811 A dopamine receptor agonist. SGTC_3301 9125354 19.7965 µM -0.776994716852486 0.20513162077166 no 2692 0.218580943660973 3767 41905162 SGTC_1273 0849-0096 14.1 µM -0.778288510040396 0.204740005043234 no 2693 0.218199473803075 3817 5286025 SGTC_2686 alizarin 95.37 µM -0.778408942667435 0.204703574164609 no 2694 0.218163984242621 3815 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_206 4546-0025 72.014 µM -0.781909704478431 0.203646279522418 no 2695 0.217133820681363 3833 6620745 YIL048W NEO1 SGTC_2147 5545932 89.7195 µM -0.78336466069923 0.203207815561463 no 2696 0.216706501153077 3835 797404 SGTC_2619 obliquin 87.91 µM -0.784026714983643 0.203008486313514 no 2697 0.216512217436484 3778 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1994 st072947 40.9 µM -0.788077764465824 0.201791354074553 no 2698 0.215325610260113 3873 5286565 YDL195W SEC31 SGTC_366 0181-0206 4.31 µM -0.789061596671499 0.20149642384781 no 2699 0.215038003036959 3781 274874 SGTC_337 1315-0038 354 µM -0.79057914513623 0.201042004601344 no 2700 0.214594810285098 3788 1626437 SGTC_306 1672-3436 11.6 µM -0.790868597552538 0.200955399963389 no 2701 0.214510337428122 3821 6797378 SGTC_2290 7904846 200 µM -0.790948027796862 0.200931638218303 no 2702 0.214487160143363 3889 2962154 SGTC_899 1083-0020 478 µM -0.79254316084731 0.200454807338705 no 2703 0.214022017874602 3879 767123 SGTC_1674 st016616 23.6 µM -0.793307465846727 0.200226575767069 no 2704 0.213799354053593 3804 625830 SGTC_1304 1165-0502 251 µM -0.793661189061779 0.200121002221042 no 2705 0.213696350086307 3833 767425 SGTC_2912 7964298 10.93 µM -0.793742449184888 0.200096753749569 no 2706 0.213672691275787 3875 2975850 SGTC_2784 7567673 72.73 µM -0.794055877110961 0.200003241662989 no 2707 0.213581451315932 3818 3471247 SGTC_670 4204-0025 119 µM -0.794058556209482 0.200002442459825 no 2708 0.213580671518893 3849 719039 SGTC_3336 9143619 71.43 µM -0.795402978946274 0.199601629352114 no 2709 0.213189563826369 3830 45595730 SGTC_1066 ketoconazole 628 nM -0.796378704804117 0.199311038881416 no 2710 0.212905975962741 3880 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_606 k015-0008 38.6 µM -0.796860937230027 0.199167514636639 no 2711 0.212765899826806 3862 1970475 SGTC_510 ag-490 170 µM -0.797637342467804 0.198936568166608 no 2712 0.212540487123344 3937 5328779 SGTC_2165 5727197 32.143 µM -0.7978044226937 0.198886890246191 no 2713 0.212491997188144 3926 1361712 SGTC_3239 9133757 49.47 µM -0.798303395967689 0.198738575167084 no 2714 0.212347223901691 3829 17036923 SGTC_2526 patulin 37.61 µM -0.799944692922935 0.198251185847536 no 2715 0.211871420930879 3900 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1511 0906-3109 28.5 µM -0.801711190661626 0.197727424606345 no 2716 0.211360020497306 3868 2882180 SGTC_2956 9076196 2.52 µM -0.802132027901895 0.197602771080374 no 2717 0.211238295000104 3846 16423868 SGTC_1285 0929-0069 65.5 µM -0.80275764717559 0.19741754819309 no 2718 0.211057413051751 3853 1206237 SGTC_1596 piperlongumine 63 µM -0.803279156510586 0.197263228701275 no 2719 0.210906701258284 3850 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2889 9059656 51.95 µM -0.806914528215291 0.196189516885591 no 2720 0.20985786400456 3925 3949838 SGTC_2302 7771753 200 µM -0.807450571887832 0.196031496021348 no 2721 0.209703470392442 3857 2203047 SGTC_3052 9092717 49.47 µM -0.807841274753938 0.195916368981034 no 2722 0.209590980560625 3820 25237534 SGTC_3237 9133362 49.47 µM -0.808782309325938 0.195639246078875 no 2723 0.209320186839066 3779 43845137 SGTC_1323 1348-1351 11.2 µM -0.809434262397285 0.195447393685489 no 2724 0.209132700509377 3797 6989654 SGTC_766 1391-0721 126 µM -0.812062347457169 0.194675177830602 no 2725 0.208377928516794 3871 1020919 YIL115C NUP159 SGTC_246 cycloheximide 667 µM -0.81221325427744 0.194630892984581 no 2726 0.208334637717513 3725 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1658 st012944 20 µM -0.812580169055179 0.194523244402481 no 2727 0.208229402620741 3757 24207260 SGTC_3051 9093778 49.47 µM -0.812954719394888 0.194413393018178 no 2728 0.208122009919835 3882 17217378 SGTC_2502 avocadyne acetate 18.59 µM -0.813098492615657 0.194371235988758 no 2729 0.208080795320851 3813 3952079 SGTC_2880 9042983 58.44 µM -0.81439195255657 0.193992219369985 no 2730 0.207710223664229 3881 6464714 SGTC_2587 piperic acid 92.2 µM -0.81458113683991 0.193936821344437 no 2731 0.207656055742421 3878 5370536 SGTC_2505 galangin 7.89 µM -0.814963957829052 0.193824751005556 no 2732 0.207546470600222 3754 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2214 7179297 48.276 µM -0.817199163789299 0.193171185886273 no 2733 0.2069073101649 3867 769744 SGTC_1510 1123-0200 71.5 µM -0.81899073952974 0.192648308927641 no 2734 0.206395848538377 3909 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2313 7726885 200 µM -0.819280516587626 0.192563817928917 no 2735 0.206313193007732 3889 726423 SGTC_345 1362-0200 395 µM -0.820688364772936 0.192153650651944 no 2736 0.20591189997867 3860 1419823 SGTC_491 tetrandrine 80.3 µM -0.822666324382766 0.191578288979147 no 2737 0.205348885313074 3860 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1652 st011932 78 µM -0.824431096074918 0.191065832636016 no 2738 0.204847326038946 3784 1551076 SGTC_1704 st028805 70.8 µM -0.825872321188006 0.19064795230997 no 2739 0.204438261650795 3894 2876101 SGTC_1960 st011366 51.8 µM -0.826178404371363 0.19055927638086 no 2740 0.204351448386746 3851 3972846 SGTC_377 3970-0964 33.1 µM -0.82887416681981 0.189779376055358 no 2741 0.203587807335742 3853 16481235 SGTC_1381 2324-0066 62.1 µM -0.829286575890408 0.189660236978763 no 2742 0.2034711325938 3923 10885928 SGTC_45 0kpi-0036 14.9 µM -0.829852547704979 0.189496810735431 no 2743 0.203311078328944 3895 2795021 SGTC_2300 7976697 71.57 µM -0.830586370523769 0.18928504601321 no 2744 0.203103668457078 3784 2236109 SGTC_777 1315-0167 517 µM -0.830724348851876 0.189245244856249 no 2745 0.203064683964791 3927 4221767 SGTC_3022 9087993 49.47 µM -0.830890820847709 0.189197231289818 no 2746 0.203017654799518 3910 17173644 SGTC_2228 7354201 200 µM -0.833700316209715 0.188388053328208 no 2747 0.202224939952964 3889 753451 SGTC_708 3448-5400 146 µM -0.833729901215122 0.188379543764355 no 2748 0.202216602242246 3843 3462195 SGTC_2234 tolnaftate 200 µM -0.833775132548115 0.188366534290446 no 2749 0.202203855446938 3872 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1905 st060207 84.5 µM -0.8355626935914 0.187852838303931 no 2750 0.201700481788889 3804 1948547 SGTC_1113 artemisinin 1.17947 µM -0.835776720021074 0.187791391024907 no 2751 0.20164026272083 3902 2240 An anti-malaria and mitochondrial poison. SGTC_2922 7999257 32.47 µM -0.83656814771407 0.187564278899866 no 2752 0.20141767799706 3849 2988377 SGTC_540 1187-0821 17.3 µM -0.837510119383033 0.187294187229284 no 2753 0.201152945625007 3843 847520 SGTC_1962 st076595 64.5 µM -0.838503370548698 0.187009652783029 no 2754 0.200874027753666 3904 279619 SGTC_103 0844-0104 51.839 µM -0.83894174626831 0.186884157372404 no 2755 0.200750999990164 3869 5375804 SGTC_1053 3366-3204 134 µM -0.839641004067606 0.186684086193095 no 2756 0.200554850722248 3914 3632071 YPR165W RHO1 SGTC_1442 4112-3290 3 µM -0.841043074144623 0.186283326504061 no 2757 0.200161902001682 3871 704353 SGTC_1934 st074720 32.6 µM -0.842978083985315 0.185731110629155 no 2758 0.199620350481786 3840 17250992 SGTC_2617 dihydrotanshinone i 20.83 µM -0.844374099958745 0.185333344873436 no 2759 0.199230195326197 3900 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_702 1488-0190 94 µM -0.845369939685419 0.185049924491954 no 2760 0.198952161323611 3944 949357 SGTC_18 0111-0177 500 nM -0.846794441200877 0.184644973424675 no 2761 0.198554853591582 3940 721752 SGTC_1208 2323-2347 50.3 µM -0.848024647437598 0.184295699531578 no 2762 0.198212122178713 3907 5412760 SGTC_277 nystatin 15.5 µM -0.848523512899847 0.184154181423302 no 2763 0.198073241734282 3885 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1075 aripiprazole 15.2 µM -0.848760239362049 0.184087050552874 no 2764 0.198007359405349 3925 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1103 duloxetine 36.1 µM -0.849310077391005 0.183931186324702 no 2765 0.197854387411906 3998 60835 A selective serotonin reuptake inhibitor. SGTC_1025 k007-0731 70 µM -0.851087765766568 0.183427822290977 no 2766 0.197360300487992 3869 6256118 SGTC_683 panaxydol 45 µM -0.851742862202639 0.183242544218536 no 2767 0.197178412708833 3890 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2975 9084847 53.72 µM -0.852358039170111 0.183068662696848 no 2768 0.197007700959862 3979 27211724 SGTC_564 3555-0129 330 µM -0.854564105691971 0.182445958567194 no 2769 0.19639625299028 3776 563260 SGTC_1386 3228-0095 33.8 µM -0.855239404851131 0.182255607388611 no 2770 0.196209312796276 3935 870181 SGTC_365 0121-0052 13.6 µM -0.856049300240624 0.182027480403304 no 2771 0.195985255250195 3962 3101739 SGTC_1722 st034304 3.6505 µM -0.856129498399343 0.182004900335417 no 2772 0.195963076880122 3911 4036148 YLR033W RSC58 SGTC_2213 7173844 200 µM -0.857058428180601 0.18174348459932 no 2773 0.195706297313632 3878 892728 SGTC_912 3474-0017 2.18 µM -0.859281936848488 0.181118708274594 no 2774 0.19509249366305 3964 3360550 SGTC_2051 5263410 176 µM -0.85945062982843 0.181071362767995 no 2775 0.195045973462531 3946 227584 SGTC_1062 mesoridazine 14.2 µM -0.859957118597489 0.180929257820132 no 2776 0.194906340366732 3925 4078 A neuroleptic. SGTC_2029 5175081 200 µM -0.862704759922077 0.180159573922901 no 2777 0.194149907328098 3919 1380876 SGTC_3175 9106517 49.47 µM -0.868421162623099 0.17856486251343 no 2778 0.192581906869373 3960 41468073 SGTC_1928 4'-methoxychalcone 40.3 µM -0.869947441576792 0.178140583038704 no 2779 0.192164563728473 3981 641818 SGTC_3309 9129340 25.759 µM -0.87046907429992 0.177995723878574 no 2780 0.19202205631786 3968 17158987 SGTC_707 0865-0008 204 µM -0.870872026595478 0.177883873536999 no 2781 0.191912016086003 3935 723043 SGTC_858 0438-0351 2.77 µM -0.871983215740865 0.177575662576406 no 2782 0.191608767032097 3922 2799119 SGTC_287 k060-0039 29.6 µM -0.874187453620572 0.176965270328145 no 2783 0.191008088734187 3974 5861974 SGTC_608 k048-0125 159 µM -0.874502546175369 0.176878124091077 no 2784 0.190922317104385 3967 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2137 5261020 140 µM -0.876921130595316 0.176210111214854 no 2785 0.190264739033761 3908 763655 SGTC_2714 st079313 56.9 µM -0.877741550867293 0.17598387433651 no 2786 0.190041995050372 3915 2939799 SGTC_2251 lansoprazole 556 µM -0.881514141851736 0.174945923669264 no 2787 0.189019801571574 3857 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1896 st058441 89 µM -0.88210616297218 0.174783394596835 no 2788 0.188859699877423 3966 688759 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.882312559351226 0.17472675461011 no 2789 0.18880390325832 3942 442882 SGTC_736 0958-0254 92.6 µM -0.8825103027526 0.174672500133523 no 2790 0.188750455390948 4039 6812352 SGTC_2673 kobusone 100 µM -0.882585887326947 0.174651764965152 no 2791 0.18873002817522 3997 6710676 An epoxy ketone and protein crosslinker. SGTC_1209 2323-2347 50.3 µM -0.883596693527786 0.174374620019178 no 2792 0.188456982291338 3929 5412760 SGTC_3 0833-0587 95.581 µM -0.886245149982089 0.173649786657721 no 2793 0.187742719347145 3870 5382644 SGTC_2149 5554786 194.827 µM -0.887181380670546 0.173394016961977 no 2794 0.187490627584257 3975 745063 YPR165W RHO1 SGTC_1240 0356-0016 42.1 µM -0.887831934281856 0.173216432930481 no 2795 0.187315581174107 3937 4305613 SGTC_2816 7982706 58.44 µM -0.888118127809759 0.173138346318503 no 2796 0.187238606235891 4016 2981853 SGTC_2630 antimycin a 100 µM -0.889072807005936 0.172878028577016 no 2797 0.186981976104641 3935 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_3167 9103034 49.47 µM -0.889294786966619 0.172817535811319 no 2798 0.186922336213504 3992 5127859 SGTC_579 4491-1009 110 µM -0.889649088528967 0.17272101143967 no 2799 0.186827169548475 4083 1271041 SGTC_1067 clotrimazole 1.36 µM -0.889783166170521 0.172684492877229 no 2800 0.186791163637463 3965 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_250 brefeldin a 552.239 µM -0.890872631410381 0.172387939086988 no 2801 0.186498752206099 3821 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1360 1598-0022 39.8 µM -0.891402907628955 0.172243714854439 no 2802 0.186356529207259 4025 761525 SGTC_3317 9138495 8.753 µM -0.89215339267002 0.17203972997855 no 2803 0.186155359866165 3894 17020139 SGTC_2393 9031399 185.94 µM -0.893534275176934 0.171664803610676 no 2804 0.185785562770059 4014 1526623 YDL150W RPC53 SGTC_283 0987-0079 11.7 µM -0.894850358588693 0.171307957176517 no 2805 0.185433543121004 3975 411556 SGTC_167 3672-0051 66.205 µM -0.895176197739845 0.171219681555013 no 2806 0.18534645321912 3890 3237971 SGTC_1955 wogonin 32.4 µM -0.895208942652647 0.171210811984375 no 2807 0.185337702602107 4047 5281703 A flavanone. SGTC_1157 4092-0394 27.6 µM -0.896519226096316 0.170856138367776 no 2808 0.184987758306699 4063 3659885 SGTC_3318 9139014 38.6185 µM -0.89718356558477 0.170676491611071 no 2809 0.184810486613289 3960 16643984 SGTC_2270 7924575 90.91 µM -0.898646322173609 0.170281368002593 no 2810 0.184420538442305 3984 1262135 SGTC_305 1682-2595 20.8 µM -0.900024578673756 0.169909606430655 no 2811 0.184053585396546 3996 226033 SGTC_1559 coumarin 343 70.1 µM -0.903407559271077 0.168999312163395 no 2812 0.183154814754244 4000 108770 A hepatotoxic, DNA x-linker. SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.904592526713645 0.168681202623478 no 2813 0.18284064797286 3941 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.904595593292775 0.168680379886874 no 2814 0.182839835376756 3955 2346 DNA damaging agent; causes G2/M arrest. SGTC_1384 3089-0840 101 µM -0.907483025737407 0.167906851401104 no 2815 0.182075710865951 3958 1069836 SGTC_883 0850-0245 24.6 µM -0.907559290588129 0.167886451435511 no 2816 0.18205555538416 4056 6823229 YPR165W RHO1 SGTC_1524 corynanthine 62.1 µM -0.910711805309447 0.167044586504593 no 2817 0.181223621135001 4113 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1578 josamycin 24.2 µM -0.911177006632162 0.166920587462965 no 2818 0.181101058540642 3991 5282165 A P450 substrate. SGTC_2089 5281248 129.67 µM -0.911848216697009 0.166741781611578 no 2819 0.18092431213065 3972 2737878 SGTC_2865 9030313 51.95 µM -0.913180509144042 0.166387234112391 no 2820 0.180573806558178 3932 42562754 SGTC_2564 betulinic acid 100 µM -0.91318985542936 0.166384748614789 no 2821 0.180571349200028 4058 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_3103 9120822 49.47 µM -0.914198446272919 0.166116670629534 no 2822 0.180306290213899 3996 17141819 SGTC_2104 5389443 200 µM -0.920503212718987 0.164447226230784 no 2823 0.178654927460444 4060 2244536 SGTC_1458 k015-0034 6.33 µM -0.921244887291078 0.164251554993807 no 2824 0.178461293897874 4022 3598957 SGTC_3191 9110352 49.47 µM -0.922631735007354 0.163886077144023 no 2825 0.178099575880527 3936 17122424 SGTC_3268 9137683 49.47 µM -0.923750319753335 0.163591679778115 no 2826 0.177808163270093 4036 1953228 SGTC_131 0141-0277 33.849 µM -0.92400837326219 0.16352381213291 no 2827 0.177740978142663 3984 1547771 SGTC_3169 9102970 49.47 µM -0.92933023613804 0.162128248680274 no 2828 0.17635898507852 4060 17027839 SGTC_2477 5967686 25.23 µM -0.930629196885502 0.161788800471812 no 2829 0.176022703069854 3997 776118 SGTC_2992 9074591 71.4286 µM -0.933229202107127 0.161110751790569 no 2830 0.17535082011862 3963 17741321 SGTC_129 0088-0017 176.636 µM -0.933949346422802 0.160923275595591 no 2831 0.17516501123689 3849 182446 SGTC_1845 st056753 3.01 µM -0.934557457203535 0.160765076190844 no 2832 0.175008206106617 3959 5375839 SGTC_3159 9100096 49.47 µM -0.935479618564805 0.160525370669331 no 2833 0.174770591075037 3964 25236875 SGTC_3321 9137793 26.8275 µM -0.937026279045213 0.16012385806855 no 2834 0.174372520219181 3977 4904192 SGTC_3057 9095946 49.47 µM -0.938839879675333 0.159653884957628 no 2835 0.173906480126479 4049 24540043 SGTC_550 4123-0385 25.7 µM -0.938904876257617 0.159637058635349 no 2836 0.173889792700774 4043 5731123 SGTC_1390 3413-2614 145 µM -0.93903628375299 0.159603043393775 no 2837 0.173856057840288 4046 3421432 SGTC_2356 9061756 188.97 µM -0.940590977701495 0.159200966068821 no 2838 0.173457253623251 4050 20104043 SGTC_2687 chenodiol 100 µM -0.940650124087256 0.159185682651567 no 2839 0.173442093122026 4105 5702181 A cholesterol synthesis inhibitor. SGTC_2389 9091542 195.52 µM -0.941023349890625 0.159089263325915 no 2840 0.173346446709326 4007 3626624 YOL127W RPL25 SGTC_1836 st055642 81 µM -0.942036616393587 0.158827688568193 no 2841 0.17308694672041 4033 8571 SGTC_2054 5233173 129 µM -0.942104815755174 0.15881009303344 no 2842 0.173069489592287 4049 6889 SGTC_2826 7992541 19.48 µM -0.943742057777553 0.158388065746897 no 2843 0.172650738135462 4037 2985066 SGTC_3112 9123419 49.47 µM -0.94619595187054 0.157756911341523 no 2844 0.172024325261135 4065 17015854 SGTC_1814 st052110 31.539 µM -0.948853173055242 0.15707532566903 no 2845 0.171347646790964 3972 674163 SGTC_1766 st045414 44.774 µM -0.948901011567083 0.157063072713637 no 2846 0.171335480019312 4060 253960 SGTC_2799 7812892 81.82 µM -0.95347220052458 0.155895146804205 no 2847 0.170175437404985 4069 20205235 SGTC_593 1203-0218 61.7 µM -0.954492544887251 0.155635235295545 no 2848 0.169917190599275 4065 3666956 SGTC_584 0986-0246 15.4 µM -0.954613102085621 0.155604544746601 no 2849 0.169886694455686 4130 53315 YDR232W HEM1 SGTC_3046 9092212 49.47 µM -0.954646501364113 0.155596042914548 no 2850 0.169878246396479 4096 25236637 SGTC_2092 5303694 80.6725 µM -0.954759658922019 0.155567240780942 no 2851 0.169849626171172 4031 1963699 SGTC_132 0417-1715 25.805 µM -0.957933183052355 0.154760912197687 no 2852 0.16904822620587 3992 6769098 SGTC_2872 9044037 25.97 µM -0.958958399758763 0.154501016422194 no 2853 0.168789851317537 4041 6465195 SGTC_2297 7971671 152.32 µM -0.960227327650226 0.154179738819836 no 2854 0.168470407992254 4060 909016 SGTC_125 0133-0007 11.75 µM -0.963145921820497 0.153442463304118 no 2855 0.167737149573794 4123 26541 SGTC_2598 perillyl alcohol 100 µM -0.963763876108283 0.153286659933998 no 2856 0.167582160707928 4095 10819 An apoptosis inducer. SGTC_1082 camptothecin 424.86 nM -0.964604516321777 0.153074879623228 no 2857 0.167371468225093 3958 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_945 3381-0768 11.3 µM -0.966295272915404 0.152649519272776 no 2858 0.166948225384537 4096 1126236 YIL048W NEO1 SGTC_1826 st055655 41.6 µM -0.96646266217137 0.152607450201265 no 2859 0.166906360839573 4077 676168 SGTC_384 k007-0144 5.16 µM -0.966743130403047 0.152536978821575 no 2860 0.166836230090092 4013 6824886 SGTC_1739 st037196 92.5 µM -0.968036999650379 0.152212156551976 no 2861 0.166512945791341 4141 612214 SGTC_3319 9138450 16.7555 µM -0.969303503805335 0.151894649315964 no 2862 0.166196890811757 3992 2029690 SGTC_2187 6125751 200 µM -0.970311815514302 0.15164218465417 no 2863 0.165945544767552 4069 874498 SGTC_3228 9131799 49.47 µM -0.971964351392581 0.151229020332266 no 2864 0.1655341418147 4058 17015818 SGTC_1518 st038567 90.8 µM -0.972871011024714 0.151002657192214 no 2865 0.165308707122548 4021 77966 SGTC_2721 ifenprodil 61.44 µM -0.975043240152747 0.1504612406182 no 2866 0.164769405838839 4040 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_58 0957-0393 9 µM -0.97629000067483 0.150151077029782 no 2867 0.164460386867607 3868 6997992 SGTC_3223 9129970 49.47 µM -0.979329958768144 0.149396597321961 no 2868 0.163708486157436 4090 17248386 SGTC_852 0418-0143 439 µM -0.979588680010836 0.149332502996272 no 2869 0.163644597465126 4083 5369229 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.981642575061761 0.148824332579956 no 2870 0.163137982514023 4010 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1016 4226-1401 38 µM -0.98204456188738 0.148725009224403 no 2871 0.163038947606813 4032 2901613 SGTC_2333 9017922 200 µM -0.982729186926531 0.148555953310442 no 2872 0.162870370916624 4123 3163164 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.983143607896684 0.148453681912748 no 2873 0.162768382241473 4128 5377381 SGTC_2765 myclobutanil 7.74 µM -0.983991630059209 0.148244552580144 no 2874 0.162559814141649 4107 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_585 0kpi-0023 191 µM -0.984661528463863 0.148079489461442 no 2875 0.162395177952552 4013 64601 SGTC_2456 5770359 74.46 µM -0.985305144757049 0.147921018157728 no 2876 0.162237103188694 4099 3118787 SGTC_830 4076-0286 57.8 µM -0.985773425284521 0.147805789430073 no 2877 0.162122154578641 4142 6866659 SGTC_1672 st016598 6.51 µM -0.987252294458961 0.147442282155628 no 2878 0.161759485548235 4097 4665860 YNL267W PIK1 SGTC_174 3553-0389 74.3 µM -0.98728388193352 0.147434524467582 no 2879 0.161751744996295 4151 738071 SGTC_1957 st077035 62.4 µM -0.988913016863134 0.147034789814708 no 2880 0.161352850633786 4084 705593 SGTC_2369 9071472 200 µM -0.98903227810991 0.147005555710578 no 2881 0.161323674692067 4145 17296037 SGTC_2962 9082311 13.18 µM -0.989150705984813 0.146976529745389 no 2882 0.161294706030744 4075 16459453 SGTC_50 0929-0078 56.389 µM -0.992411761626107 0.146178774480344 no 2883 0.160498351903549 3941 1377751 SGTC_1457 k015-0032 57.3 µM -0.993170073471904 0.145993685456972 no 2884 0.160313539870577 4083 4302660 SGTC_1265 0819-1001 68.8 µM -0.994098626630474 0.145767258416975 no 2885 0.160087426958202 4048 3106768 SGTC_2202 7226349 200 µM -0.99578063914965 0.145357702199865 no 2886 0.159678369630156 4038 844334 SGTC_1697 st025554 27.742 µM -0.99634867296528 0.145219565655668 no 2887 0.159540381175647 4058 1269519 SGTC_2100 5377183 190 µM -0.9966969806396 0.145134906620883 no 2888 0.15945580785946 4104 2844202 SGTC_675 1309-0189 238 µM -0.997995020087354 0.14481970007623 no 2889 0.159140886727676 4112 4246530 SGTC_1 0258-0098 57.368 µM -1.00204240831776 0.14383982286162 no 2890 0.158161555592873 4041 6790032 YDR047W HEM12 SGTC_392 N-ethylmaleimide 8.33 µM -1.0020794577959 0.143830873850227 no 2891 0.158152609179814 4029 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_887 0885-0007 9.62 µM -1.00474759600443 0.143187393407612 no 2892 0.157509201646182 4169 5719458 SGTC_1677 st019204 53.9 µM -1.00647866740567 0.1427709489479 no 2893 0.157092684184412 4118 3945625 SGTC_2012 4023501 200 µM -1.00794760270252 0.142418209441636 no 2894 0.156739808633467 4126 3477460 SGTC_1188 1403-0014 4.57 µM -1.00800323780556 0.142404861226845 no 2895 0.156726453930639 4088 9614867 SGTC_1182 1222-0449 220 µM -1.00871653997324 0.142233797664943 no 2896 0.156555298556848 4095 658318 SGTC_1791 st048313 56.1 µM -1.00887958910903 0.142194714883246 no 2897 0.156516192541466 4097 1204976 SGTC_479 n-linoleoylglycine 10 µM -1.00985788171964 0.141960371344664 no 2898 0.156281692054695 4132 6433346 An anti-infammatory. SGTC_965 1291-5240 308 µM -1.01197282238579 0.141454645348386 no 2899 0.155775524078161 4118 2834598 SGTC_3036 9090181 49.47 µM -1.01240121970247 0.141352355583399 no 2900 0.155673127708528 4132 25236586 SGTC_932 2857-0803 154 µM -1.01276354866677 0.141265880308399 no 2901 0.155586557783872 4163 674898 SGTC_60 0986-0278 202 µM -1.01283701684745 0.141248350392549 no 2902 0.155569008175111 4056 3110598 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.01506876673453 0.140716545235205 no 2903 0.155036524362266 4168 6710655 SGTC_2307 7538926 6.34 µM -1.01520739392564 0.140683556550718 no 2904 0.155003488389311 4093 96582 SGTC_1838 st055369 84.5 µM -1.01665138871337 0.140340245638556 no 2905 0.154659649254942 4109 676036 SGTC_3243 9134147 49.47 µM -1.01765224979187 0.140102624216054 no 2906 0.154421623580537 4173 24282180 SGTC_1432 4049-0298 68.4 µM -1.01833774060837 0.139940034856551 no 2907 0.154258739356819 4129 741646 SGTC_636 0kpi-0074 126 µM -1.01926734199482 0.139719750626074 no 2908 0.154038031913946 4109 616434 SGTC_2720 fluspirilene 36.88 µM -1.0217406918693 0.139134798534399 no 2909 0.153451823144296 4119 3396 An atypical antipsychotic. SGTC_815 1582-0027 36.9 µM -1.02507346006236 0.138349231905091 no 2910 0.152664263588696 4163 3128206 SGTC_978 1416-0512 87.4 µM -1.02761965724082 0.137751108800958 no 2911 0.152064386924461 4209 6814003 SGTC_2560 caryophyllene 100 µM -1.02783932696091 0.137699589346694 no 2912 0.15201270683149 4156 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_3085 9117376 49.47 µM -1.02977764973613 0.137245561658551 no 2913 0.15155719743185 4220 16480349 SGTC_1387 3342-1166 1.8 µM -1.03078514887641 0.137009971985493 no 2914 0.151320792055229 4085 3418228 SGTC_805 3852-0218 479 µM -1.03226282387339 0.136664938341501 no 2915 0.150974505790075 4088 6615355 SGTC_1783 st039459 87.517 µM -1.03287486764109 0.136522201707384 no 2916 0.150831230762482 4229 729761 SGTC_2712 st079126 47.7 µM -1.0335296120396 0.136369619640639 no 2917 0.150678060066121 4118 3152970 SGTC_319 1348-1596 45.5 µM -1.03386021654326 0.136292619692159 no 2918 0.150600757922441 4225 5380505 SGTC_40 0327-0103 19.753 µM -1.03418212035042 0.136217674782025 no 2919 0.150525515564409 3985 409036 SGTC_1661 st013063 9.66 µM -1.03590798251056 0.135816344450861 no 2920 0.150122536603667 4179 721395 SGTC_733 4069-0007 56.1 µM -1.03702446960041 0.135557149393528 no 2921 0.149862226699603 4127 5717425 YNL287W SEC21 SGTC_1294 1000-1494 117 µM -1.03722894889792 0.135509715795886 no 2922 0.149814584815278 4124 712797 YDL207W GLE1 SGTC_1807 st050092 58.9 µM -1.03783195431433 0.135369901279528 no 2923 0.149674148666543 4154 5008496 SGTC_2534 helenine 20.12 µM -1.03994264432564 0.134881289713671 no 2924 0.149183274279715 4131 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_654 1124-0271 80.9 µM -1.04059537417366 0.134730432058763 no 2925 0.149031689511124 4114 5403748 SGTC_1687 st020778 55.3625 µM -1.04228197573229 0.13434116422822 no 2926 0.148640483191986 4155 4259299 SGTC_1358 1509-0022 2.48 µM -1.04443083960362 0.133846326022742 no 2927 0.148143050757828 4172 3258434 SGTC_1966 st070145 16.1 µM -1.04490734549394 0.133736766646721 no 2928 0.148032897263526 4108 3748532 SGTC_2936 9038235 15.59 µM -1.04639040855195 0.133396171851211 no 2929 0.147690409630141 4079 4749415 SGTC_1610 st001799 48.1 µM -1.04639502220635 0.133395113228195 no 2930 0.147689345015532 4066 621897 SGTC_342 k048-0088 23.3 µM -1.04812110692178 0.132999461084121 no 2931 0.147291406422591 4122 6820570 SGTC_78 0336-0123 156.75 µM -1.04966961746301 0.132645200490484 no 2932 0.146935018594311 3955 6765896 SGTC_1944 st076371 56.9 µM -1.05086469330101 0.13237224172372 no 2933 0.146660369064122 4117 24208455 SGTC_966 1300-0360 30.2 µM -1.0536121643707 0.131746180193149 no 2934 0.146030258815749 4123 70588 SGTC_2248 tofa 1.1 µM -1.05415494986378 0.131622738668303 no 2935 0.145905990831905 4117 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1334 1486-0610 236 µM -1.05520651557278 0.131383816354452 no 2936 0.145665442452302 4233 3742339 SGTC_2151 5563267 85.4165 µM -1.055921507512 0.131221536825774 no 2937 0.145502038552816 4192 5310824 SGTC_1649 st011737 51.3 µM -1.05600555655305 0.131202469569643 no 2938 0.145482838127574 4141 1761035 SGTC_2735 sertaconazole 140 nM -1.05615181347135 0.131169294477732 no 2939 0.145449430803417 4283 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1721 st082152 9.2685 µM -1.06067277364595 0.130146673200118 no 2940 0.144419318656406 4088 5296051 SGTC_3274 9138298 49.47 µM -1.0627316401005 0.129682799823525 no 2941 0.143951833991068 4122 17015756 SGTC_3147 9097027 49.47 µM -1.06277276090554 0.129673546769752 no 2942 0.143942507540171 4146 25236841 SGTC_208 k072-0098 12.366 µM -1.06319668360963 0.129578181821356 no 2943 0.143846383028772 4122 5948901 SGTC_894 0960-0238 55.9 µM -1.06429124588019 0.129332175612686 no 2944 0.143598391231151 4159 6741907 YDL195W SEC31 SGTC_1231 0242-0792 125 µM -1.0650423322994 0.129163554025257 no 2945 0.143428386800158 4144 3707635 SGTC_495 decylubiquinone 155 µM -1.06610141920473 0.128926044297143 no 2946 0.143188899074006 4227 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3220 9131269 49.47 µM -1.06873923598599 0.128335807529365 no 2947 0.142593593224336 4176 17722206 SGTC_706 4262-0057 46.9 µM -1.06975994030361 0.128107919381578 no 2948 0.142363689114645 4163 883298 SGTC_1093 fluphenazine 7.97 µM -1.07323345901764 0.127334508674464 no 2949 0.141583190979742 4167 6602611 An atypical antipsychotic. SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.073730756211 0.127224047243512 no 2950 0.141471686209478 4153 688667 SGTC_304 1310-0298 97 µM -1.07381690100835 0.127204919229474 no 2951 0.141452376734249 3973 1550234 SGTC_2253 7938677 135.83 µM -1.0753551375181 0.126863698457552 no 2952 0.141107879576048 4236 2301972 SGTC_1256 0570-0116 285 µM -1.07584767257066 0.126754576205444 no 2953 0.140997693789698 4172 410638 SGTC_926 2268-1401 59.4 µM -1.07800064074912 0.126278348565575 no 2954 0.140516735093748 4137 2931578 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.08027880386555 0.125775787652312 no 2955 0.1400090227784 4132 6708514 SGTC_1839 st053978 48 µM -1.0809256935796 0.125633338981445 no 2956 0.139865084198184 4187 3788398 SGTC_1767 st044992 70.3 µM -1.08169634875674 0.125463783453399 no 2957 0.139693738054738 4212 9600693 SGTC_1848 st056003 16.4 µM -1.08410767270124 0.124934288467341 no 2958 0.139158530643449 4188 146492 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.08481588869588 0.124779070577234 no 2959 0.139001603456884 4230 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2818 7996756 12.99 µM -1.08501334772102 0.124735818021399 no 2960 0.138957871780576 4197 2241621 SGTC_26 0302-0163 425.158 µM -1.08549172560187 0.124631074834742 no 2961 0.138851963239649 4239 3100915 SGTC_2923 7992654 58.14 µM -1.08676484394849 0.124352618899447 no 2962 0.138570374196466 4182 2985126 SGTC_2990 9074105 71.4286 µM -1.0875973449593 0.124170770054332 no 2963 0.138386451683813 4091 6502001 SGTC_2621 lithochol-11-enic acid 100 µM -1.0888087166906 0.123906494340477 no 2964 0.138119123456653 4134 6708711 SGTC_1243 0416-0003 5.65 µM -1.08920578908271 0.123819953822484 no 2965 0.138031573314575 4166 2141977 SGTC_2589 lobaric acid 100 µM -1.09080848949652 0.123471081042514 no 2966 0.137678580059516 4172 73157 A novel microtubule depolymerizer. SGTC_3041 9091929 49.47 µM -1.09223883181731 0.123160308792821 no 2967 0.137364069197799 4189 25236887 SGTC_2448 5185112 27.17 µM -1.09422974625849 0.12272865356248 no 2968 0.136927114193844 4222 5718189 SGTC_144 4161-2749 112.381 µM -1.09521950446437 0.122514456910938 no 2969 0.136710241362949 4135 797501 YMR168C CEP3 SGTC_3204 9114183 49.47 µM -1.09578004929781 0.122393264071826 no 2970 0.136587520690583 4171 17027248 SGTC_372 0155-0182 15.9 µM -1.09931027196199 0.12163194422066 no 2971 0.135816376704243 4085 771486 SGTC_1059 3448-6867 171 µM -1.0994303105371 0.121606115610209 no 2972 0.135790207924205 4137 3934407 SGTC_1253 0550-0034 176 µM -1.10167056522324 0.121124788839129 no 2973 0.13530245902854 4217 5969915 SGTC_72 0744-0168 198.391 µM -1.10759812604532 0.119857699993632 no 2974 0.134017706557413 4094 677577 SGTC_2769 toremifene 3.73 µM -1.10768179590341 0.119839881674074 no 2975 0.13399963196678 4248 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1355 1499-0035 1.68 µM -1.10821456243335 0.119726467606195 no 2976 0.133884581579381 4191 1548538 SGTC_3081 9117243 49.47 µM -1.10996344576986 0.119354701611646 no 2977 0.133507389309762 4186 45595589 SGTC_885 0865-0106 16.8 µM -1.11209867037463 0.118901915131634 no 2978 0.133047864181339 4135 2793380 SGTC_2112 5488546 200 µM -1.11265234318468 0.118784703997899 no 2979 0.132928885330594 4165 600757 SGTC_1033 k072-0102 21.3 µM -1.11339196190535 0.118628255957613 no 2980 0.132770062846341 4167 5965931 SGTC_3353 9151644 39.2805 µM -1.11352832917155 0.118599426740467 no 2981 0.13274079421172 4233 4909158 SGTC_2971 9092186 9.93 µM -1.11372819497414 0.118557182330465 no 2982 0.132697904856356 4217 25236400 SGTC_1919 st067113 52.3 µM -1.11374834056497 0.11855292487037 no 2983 0.132693582328214 4224 1268243 SGTC_370 0180-0345 38.7 µM -1.11495642094848 0.118297813182872 no 2984 0.132434548468362 4063 3989527 SGTC_1802 st050112 57.9 µM -1.1156154282428 0.118158813596014 no 2985 0.132293392600222 4205 4662563 SGTC_3059 1327-0034 3 µM -1.1156826410066 0.118144643392882 no 2986 0.132279001812654 4078 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_317 4495-0002 170 µM -1.11749569063504 0.117762858618676 no 2987 0.13189122055876 4236 15991618 SGTC_295 k015-0027 31 µM -1.11754543858713 0.117752395214213 no 2988 0.131880591361647 4244 3887424 SGTC_195 4234-0266 16.654 µM -1.11829337104073 0.117595163117596 no 2989 0.131720858589315 4212 2303354 SGTC_1707 st032323 6.317 µM -1.11894016724462 0.117459312001029 no 2990 0.131582832738591 4075 3132057 YMR211W DML1 SGTC_3322 9139058 2.11 µM -1.12028777119053 0.117176622397355 no 2991 0.131295575761536 4286 4908926 YPR165W RHO1 SGTC_52 0329-0193 875 nM -1.1213014746484 0.116964293648756 no 2992 0.131079779036258 4296 3739292 SGTC_3279 9140807 49.47 µM -1.12266077605637 0.116680004651874 no 2993 0.130790796331832 4259 45595718 SGTC_1502 4534-4282 27.7 µM -1.12269799896078 0.116672226622886 no 2994 0.130782889072463 4166 3278949 SGTC_38 0929-0051 58.268 µM -1.1243986094264 0.116317262235888 no 2995 0.130421980860509 4210 1379719 SGTC_94 0334-0113 514.748 µM -1.12471465452424 0.116251379413 no 2996 0.130354984883247 4233 6795178 SGTC_3130 9127414 49.47 µM -1.12491354106051 0.116209933064093 no 2997 0.130312836657805 4221 1494646 SGTC_2131 toluylene red 5.2905 µM -1.1251600758339 0.116158571763972 no 2998 0.130260603859931 4186 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_6 0844-0013 19.835 µM -1.12684083815397 0.115808842998434 no 2999 0.129904890330188 4354 1584900 SGTC_1761 st044296 37 µM -1.12732547229816 0.115708140586566 no 3000 0.129802448255439 4203 1826700 SGTC_977 1348-1378 135 µM -1.12828919073798 0.115508073818177 no 3001 0.129598903488453 4205 X977 SGTC_2806 7952793 58.44 µM -1.12834972227741 0.115495515753803 no 3002 0.129586126144346 4278 2972490 SGTC_1873 rapamycin 2 nM -1.12999882974449 0.115153759884306 no 3003 0.129238358796108 4177 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_15 0266-0086 27.098 µM -1.1324139945879 0.11465454722364 no 3004 0.12873021199561 4278 1712902 YIL048W NEO1 SGTC_169 k015-0017 16.025 µM -1.13308853771403 0.114515395233629 no 3005 0.128588537184583 4201 1840002 SGTC_2697 mebhydrolin 72.4 µM -1.13383913672087 0.114360694973707 no 3006 0.128431015535725 4301 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1771 st048882 4.1505 µM -1.136382824893 0.113837541439371 no 3007 0.127898190334186 4256 4580403 SGTC_2447 5741742 33.78 µM -1.14102907995965 0.112886365945351 no 3008 0.12692891092076 4278 1776504 SGTC_764 1951-2361 146 µM -1.14355683488427 0.112371276450321 no 3009 0.126403735808647 4243 5438930 SGTC_2853 9015042 58.44 µM -1.14444144401197 0.112191413828381 no 3010 0.126220304483942 4161 6457456 SGTC_898 1000-0849 28.3 µM -1.14502704687988 0.112072459725496 no 3011 0.126098976791757 4233 6751807 SGTC_3305 9127027 53.8275 µM -1.14561292075431 0.111953540827255 no 3012 0.125977674334472 4173 41905295 SGTC_2657 nystatin 74.44 µM -1.15113877172853 0.110836357349598 no 3013 0.124837574778642 4267 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_835 0312-0010 67.2 µM -1.15354284929256 0.110352816919578 no 3014 0.124343820276873 4239 1626196 SGTC_2677 mitomycin C 100 µM -1.15533154828581 0.109994032429115 no 3015 0.123977340733595 4290 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1130 3454-2858 15.9 µM -1.15604514127127 0.109851130870968 no 3016 0.123831346598517 4250 715628 YIL048W NEO1 SGTC_3267 9137951 49.47 µM -1.15697799547946 0.109664521864421 no 3017 0.123640675317709 4275 16643986 SGTC_1495 4469-0029 237 µM -1.1572993627535 0.109600287998665 no 3018 0.123575036901868 4253 793680 SGTC_614 0462-0418 107 µM -1.15734052716895 0.109592062138792 no 3019 0.123566630942358 4016 5188303 SGTC_2786 7743617 45.45 µM -1.1614138667638 0.108780280168303 no 3020 0.122736816225181 4200 583674 SGTC_3161 9100388 49.47 µM -1.16180174496613 0.10870320540084 no 3021 0.122658002551911 4329 25236368 SGTC_105 0111-0055 734.78 µM -1.16777308079576 0.107521602172156 no 3022 0.121449154603134 4266 5179370 SGTC_1556 plumbagin 1.48 µM -1.16832472109626 0.107412912885252 no 3023 0.121337903642241 4182 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2760 etidronate 98.04 µM -1.1698990671878 0.10710315619644 no 3024 0.121020794668915 4206 3305 A chelator and antioxidant. SGTC_3212 9128307 49.47 µM -1.17039139089186 0.107006422584606 no 3025 0.12092174930394 4176 27243542 SGTC_690 glyoxal 20.3 µM -1.170561443336 0.106973024688733 no 3026 0.120887551520505 4066 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_512 prima-1 270 µM -1.1705749686694 0.106970368668247 no 3027 0.120884831849335 4272 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2322 7413319 38.22 µM -1.17317356682058 0.106460954411922 no 3028 0.12036310491949 4259 1840400 SGTC_77 0828-0286 12.516 µM -1.17485205627363 0.106132845411788 no 3029 0.120026954746611 4160 745345 SGTC_2390 9097792 176.6 µM -1.17512717140223 0.106079136011013 no 3030 0.11997192076559 4282 4497149 SGTC_1667 st014849 34.6 µM -1.17603097219164 0.10590282956701 no 3031 0.119791249824223 4336 5348460 SGTC_2658 polymyxin b sulfate 77.05 µM -1.17758387630484 0.105600395795199 no 3032 0.119481270460424 4286 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1144 3486-0183 12.5 µM -1.17899178368554 0.105326740889424 no 3033 0.119200723775014 4262 6744069 SGTC_2085 5307070 144.047 µM -1.17973673811548 0.105182151842291 no 3034 0.119052468666725 4200 2840351 SGTC_607 4491-0986 66.8 µM -1.18073383878098 0.104988848305643 no 3035 0.118854237165011 4285 698981 YDR232W HEM1 SGTC_2979 9012552 45.46 µM -1.18120540233148 0.104897517968687 no 3036 0.118760567843407 4277 17100905 SGTC_2472 5377652 49.4 µM -1.18357979328431 0.104438530360418 no 3037 0.118289721561537 4338 1610903 SGTC_2082 5219693 150 µM -1.18637833324032 0.103899422028687 no 3038 0.11773646213106 4256 2834649 SGTC_2142 5622915 118.518 µM -1.18714518664163 0.103752048969449 no 3039 0.117585178656793 4290 5322196 SGTC_1991 st073000 8.92 µM -1.19010995832163 0.10318370886376 no 3040 0.117001588372647 4329 4301969 YIL048W NEO1 SGTC_796 1234-0020 70.7 µM -1.19080042726872 0.103051672692282 no 3041 0.116865970564925 4218 46495034 SGTC_1210 3013-0140 750 nM -1.1955035270797 0.102155577688665 no 3042 0.115945179511343 4298 905973 SGTC_260 nsc-65238 3.989 µM -1.19855083562497 0.10157799972504 no 3043 0.115351322461435 4281 3246252 SGTC_533 1222-0222 6.71 µM -1.19952509643215 0.10139384381409 no 3044 0.115161916150836 4310 3982874 SGTC_2850 9015429 58.44 µM -1.20003608811752 0.101297352859117 no 3045 0.115062662564275 4297 6457570 SGTC_47 0149-0135 24.25 µM -1.20052362560673 0.101205353160814 no 3046 0.114968021374402 4296 5239155 SGTC_1558 st069300 45.6 µM -1.20457504172161 0.100443193893866 no 3047 0.114183698253903 4229 24208000 SGTC_2835 9006588 71.43 µM -1.20462965135697 0.100432949321627 no 3048 0.114173152340821 4334 2345538 SGTC_1117 retinoic acid 1.10837 µM -1.20506799663723 0.100350744936115 no 3049 0.114088526637944 4325 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1702 st027038 51 µM -1.20944903152046 0.099531851067449 no 3050 0.113245190580759 4315 5521182 SGTC_456 gingerol 170 µM -1.21070368777675 0.0992982354190417 no 3051 0.113004494270891 4342 442793 A herb. SGTC_651 3253-0966 34.4 µM -1.21233674443645 0.0989947628603872 no 3052 0.112691751920202 4310 781462 SGTC_2081 5214970 32.255 µM -1.21431659529209 0.0986277557501593 no 3053 0.112313425436843 4252 2063512 SGTC_1233 0325-0408 14.2 µM -1.21585822311023 0.0983426729486287 no 3054 0.112019467416295 4320 12874 SGTC_1212 0520-0165 585 µM -1.21681897384527 0.0981653133225588 no 3055 0.11183654965012 4416 5403258 SGTC_1588 farnesol 29.9 µM -1.21821388330951 0.0979082229755121 no 3056 0.111571352590477 4313 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3295 9122362 53.5725 µM -1.21987281953425 0.0976031137189007 no 3057 0.111256545505151 4304 4730473 SGTC_1362 1611-0397 101 µM -1.22153419415733 0.0972982553397437 no 3058 0.110941913530228 4269 27816 SGTC_2930 9013230 14.89 µM -1.22596307248749 0.0964889811098156 no 3059 0.11010628585691 4309 2995857 SGTC_2652 actinonin 100 µM -1.22782906725889 0.0961494988653094 no 3060 0.109755570783785 4338 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1464 k208-0027 110 µM -1.22985455163667 0.0957819952936797 no 3061 0.109375787946891 4306 X1464 SGTC_1474 0330-0125 5.35 µM -1.23156426682995 0.0954725899386527 no 3062 0.109055947973845 4351 X1474 SGTC_1666 st014829 29 µM -1.23659200990734 0.094566987919103 no 3063 0.108119293869511 4308 3858230 SGTC_401 neomycin 50 µM -1.23776260513149 0.0943570509495059 no 3064 0.107902048969429 4297 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2385 9074692 200 µM -1.24236693188107 0.0935346357677957 no 3065 0.107050605281696 4346 17046906 SGTC_3247 9135149 49.47 µM -1.2425172802215 0.0935078703999035 no 3066 0.10702288442317 4355 8934436 YOR116C RPO31 SGTC_3232 9132874 49.47 µM -1.2451112768004 0.0930469713222063 no 3067 0.106545424757532 4280 3784940 SGTC_1150 3909-7983 10.9 µM -1.24618922246635 0.0928559375266944 no 3068 0.10634746741438 4313 23965914 SGTC_1874 staurosporine 7.6 µM -1.24708377513191 0.0926976249964095 no 3069 0.106183390717319 4328 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1481 3346-2004 36 µM -1.24813764281455 0.0925113740804937 no 3070 0.105990327548505 4403 2770522 SGTC_3092 9117248 49.47 µM -1.25413831369952 0.0914561442398599 no 3071 0.104895868226112 4455 17141857 SGTC_509 pifithrin 175 µM -1.25436994076142 0.0914155917358323 no 3072 0.104853786510127 4404 4817 A p53 inhibitor. SGTC_3082 9117008 49.47 µM -1.255413300114 0.0912330890440144 no 3073 0.104664381821335 4359 41448529 SGTC_573 3702-0553 84.7 µM -1.25542142061931 0.0912316696789441 no 3074 0.104662908649961 4267 1222756 SGTC_1168 k815-0004 80.5 µM -1.25857436055287 0.0906818108551592 no 3075 0.104092056372687 4310 642433 SGTC_1623 st003709 20.3 µM -1.25925021582287 0.0905642654711171 no 3076 0.103969984455189 4309 16192618 SGTC_2611 pyromycin 23.93 µM -1.25966885808119 0.0904915115684013 no 3077 0.103894422035545 4303 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_262 fenpropimorph 62.5 µM -1.26154362945467 0.0901662359336892 no 3078 0.103556525581697 4350 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_972 1319-0219 195 µM -1.26346290818926 0.0898341387657935 no 3079 0.103211434274197 4322 23903702 SGTC_1681 tripelennamine 100 µM -1.26535235874899 0.0895080917613938 no 3080 0.102872522581231 4267 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2418 pentamidine 31.67 µM -1.26785609566872 0.0890773992554844 no 3081 0.102424672671602 4290 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1506 4226-2149 212 µM -1.27045174973383 0.0886325255351903 no 3082 0.101961879791618 4344 991114 SGTC_484 loperamide 105 µM -1.27523632327724 0.0878168292202574 no 3083 0.101112804161337 4419 3955 An opioid-receptor agonist. SGTC_2006 4011487 200 µM -1.27573292653087 0.0877324877954649 no 3084 0.101024972470067 4343 45595294 SGTC_648 0375-0473 33.3 µM -1.27605247384542 0.0876782489166836 no 3085 0.100968485175921 4318 1713139 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.27832215865031 0.0872937200241397 no 3086 0.100567928956298 4469 16725076 SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.28136484513561 0.0867802066829748 no 3087 0.100032773041129 4460 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1396 3511-0007 98.6 µM -1.28419292080297 0.0863049403159758 no 3088 0.099537230783088 4381 X1396 SGTC_2377 9073351 62.6 µM -1.28432396652295 0.0862829649838215 no 3089 0.0995143122047675 4341 7337946 YHR072W ERG7 SGTC_2968 9090663 33.37 µM -1.28522903377262 0.0861313065994884 no 3090 0.0993561303404131 4313 25236811 SGTC_153 4077-0274 519.67 µM -1.28945406891541 0.0854259723817042 no 3091 0.0986201372885233 4407 3121976 SGTC_2291 7917025 104.35 µM -1.29010954898856 0.0853169342445326 no 3092 0.0985063124429418 4252 2964612 SGTC_1765 st044815 90.4 µM -1.29184879273597 0.0850281190229448 no 3093 0.0982047570840722 4388 645695 SGTC_116 0155-0182 31.788 µM -1.29287348560371 0.0848583040411923 no 3094 0.098027409591194 4237 771486 SGTC_7 0192-1582 4.227 µM -1.29608893424982 0.0843270816880467 no 3095 0.0974724234563534 4412 252616 SGTC_3281 9140613 49.47 µM -1.29610171462928 0.0843249752399159 no 3096 0.0974702221718345 4359 16013766 SGTC_2731 amoxapine 43.43 µM -1.29652580196223 0.0842551000228372 no 3097 0.0973971983145505 4519 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_745 0469-0705 296 µM -1.29712719787319 0.084156084882889 no 3098 0.0972937124050902 4404 3486736 SGTC_3102 9121669 49.47 µM -1.3023406001222 0.0833013966700907 no 3099 0.0963999892227516 4405 41905072 SGTC_2987 9018338 71.43 µM -1.30265312539179 0.0832503691739085 no 3100 0.0963466059336131 4375 5055682 SGTC_2513 baicalein 25.65 µM -1.30417814543681 0.0830017089357044 no 3101 0.0960864247603926 4366 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1108 betulinic acid 729.144 nM -1.30865674430256 0.0822746860563208 no 3102 0.0953253250988205 4358 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_546 peri-Naphthalide 147 µM -1.30952355313617 0.0821345302837639 no 3103 0.0951785323909462 4310 223824 A penicillin ester. SGTC_906 1165-0455 526 µM -1.31117413563491 0.0818681422658269 no 3104 0.0948994692590736 4363 3252859 SGTC_1299 1079-1439 3.74 µM -1.31373243886668 0.0814565443889964 no 3105 0.0944681302409594 4350 323161 SGTC_673 1082-0474 110 µM -1.31738991779182 0.0808708165192264 no 3106 0.0938539793566384 4377 3098046 SGTC_1207 2099-0101 141 µM -1.31773237734775 0.080816136467388 no 3107 0.0937966260013433 4380 5837381 SGTC_2817 7995342 71.43 µM -1.31849840855737 0.0806939263662048 no 3108 0.0936684287244995 4370 18879975 SGTC_2222 6885208 172.143 µM -1.31968618246955 0.0805047088634936 no 3109 0.0934699076148224 4373 609514 SGTC_11 0438-0307 1.3 µM -1.32008063767579 0.0804419446451822 no 3110 0.0934040482948393 4364 4011476 SGTC_389 tpck 16.7 µM -1.32090259898544 0.0803112760680567 no 3111 0.0932669215344875 4421 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3012 9080433 71.4286 µM -1.3212949826099 0.0802489547707469 no 3112 0.0932015131496266 4382 17688859 SGTC_1013 4112-3890 241 µM -1.32151498868892 0.0802140277578483 no 3113 0.0931648540721381 4327 705171 SGTC_1447 4239-0816 81.9 µM -1.33242040352471 0.0784971046304756 no 3114 0.0913610405565849 4395 1341554 SGTC_2772 vinpocetine 57.06 µM -1.33327641083886 0.0783635251762908 no 3115 0.0912205559427217 4400 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_178 4092-0806 87.505 µM -1.33854695267283 0.0775448551773945 no 3116 0.0903591026697798 4288 2169044 SGTC_385 1494-0393 12.4 µM -1.33981842350588 0.077348334174719 no 3117 0.090152192232439 4362 3090647 SGTC_197 4544-0043 41.561 µM -1.35146040403215 0.0755664810614437 no 3118 0.0882739978030152 4415 896523 SGTC_2484 5809818 12.04 µM -1.35378503942405 0.0752144620784244 no 3119 0.087902483997522 4366 2870548 SGTC_350 k064-0020 19.8 µM -1.35413625827828 0.0751613859851661 no 3120 0.0878464551721415 4426 2790705 SGTC_102 gallobenzophenone 83.616 µM -1.35640894795599 0.0748186278263899 no 3121 0.0874845439201201 4399 70837 SGTC_2858 9025781 8.96 µM -1.36757368854294 0.0731521023100513 no 3122 0.085722778505838 4260 4894980 YPL153C RAD53 SGTC_1564 D-Arginine 115 µM -1.36778967208098 0.0731201454918333 no 3123 0.0856889607132764 4415 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2824 7998404 51.95 µM -1.36872719255191 0.0729815542370567 no 3124 0.0855422834737685 4369 837851 SGTC_70 0141-0289 43.283 µM -1.37059537131487 0.0727059857592391 no 3125 0.0852505633412763 4375 352408 SGTC_644 1498-1197 63.3 µM -1.37101994555622 0.0726434695666936 no 3126 0.0851843692279168 4440 6741615 SGTC_2911 7942208 15.64 µM -1.38029052507078 0.0712886686955308 no 3127 0.0837486055433808 4433 1243384 SGTC_145 3737-0113 38.366 µM -1.38088339628984 0.0712026909669932 no 3128 0.0836574079499477 4393 6849351 SGTC_1680 diphenhydramine 100 µM -1.38358315269911 0.0708121807663461 no 3129 0.083243064938892 4390 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1612 st002233 45.4 µM -1.38459804028385 0.0706658071720627 no 3130 0.0830877055225327 4437 1035021 SGTC_2552 juarezic acid 87.02 µM -1.38854942291467 0.070098127673442 no 3131 0.0824849030670664 4370 1549512 SGTC_694 1315-0438 43.2 µM -1.38919008427501 0.0700064178230159 no 3132 0.0823874780618484 4440 6793154 SGTC_523 1934-0222 13.7 µM -1.39222180004807 0.0695736831797128 no 3133 0.0819276216393748 4378 1361595 SGTC_1776 st049249 45.9 µM -1.39297290429368 0.0694667926478976 no 3134 0.0818139922425771 4447 1822314 SGTC_2434 5670830 169.91 µM -1.39846095371383 0.0686896159973635 no 3135 0.0809873450787616 4452 1549830 SGTC_2614 arthonioic acid 13.39 µM -1.40284533641628 0.0680735644406784 no 3136 0.0803314821999685 4290 6710684 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.40404583224131 0.0679056283129485 no 3137 0.0801526010338575 4440 6708561 SGTC_1978 st071761 42 µM -1.4049926020761 0.0677734114469938 no 3138 0.080011739073765 4450 5147680 SGTC_2781 5567276 71.43 µM -1.4094299200964 0.0671563862047974 no 3139 0.0793540410288045 4448 2853274 SGTC_2558 carylophyllene oxide 100 µM -1.40953238590125 0.0671421894438663 no 3140 0.0793389020614609 4554 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2109 5483026 200 µM -1.41115085456483 0.0669182563577553 no 3141 0.0791000688272318 4444 759335 SGTC_1318 1280-3875 124 µM -1.4136366061324 0.0665754507282336 no 3142 0.0787343137093493 4443 373245 SGTC_373 0844-0104 25.9 µM -1.41723907869177 0.0660810545252326 no 3143 0.0782065199620465 4463 5375804 SGTC_207 4185-0010 4.486 µM -1.41833156961247 0.0659316866762322 no 3144 0.0780469919516312 4517 3761753 SGTC_1389 3405-0187 19 µM -1.42185592592735 0.0654516116699789 no 3145 0.0775340401126669 4439 799890 SGTC_218 alverine citrate 93.75 µM -1.4227312578893 0.0653327984497043 no 3146 0.0774070378162697 4498 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_371 0195-0006 7.36 µM -1.42484025439216 0.0650472209252586 no 3147 0.077101691608672 4302 3928593 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.42856535929235 0.0645451755223001 no 3148 0.076564598262978 4509 279621 SGTC_1733 st037357 54.9 µM -1.42970319695322 0.0643924268097287 no 3149 0.07640111116397 4362 1272339 YGL099W LSG1 SGTC_2098 5376439 882.5 nM -1.43201172069265 0.0640833828452702 no 3150 0.0760702335068805 4493 2844116 SGTC_2855 9016525 58.44 µM -1.43422602700445 0.0637880365330358 no 3151 0.0757538860094776 4403 43811474 SGTC_480 am 92016 50 µM -1.43592242416038 0.0635624865919218 no 3152 0.0755122084259395 4481 2129 K+ channel blocker. SGTC_2039 Aminomethylbenzodioxan 200 µM -1.43820088093727 0.0632605241865993 no 3153 0.0751885326765743 4466 15053 SGTC_3288 9119690 36.221 µM -1.4383722093287 0.06323786337246 no 3154 0.0751642367305115 4437 17595618 YKL019W RAM2 SGTC_2878 9043973 25.97 µM -1.43976936796216 0.0630533035169907 no 3155 0.0749663301522702 4473 6465167 SGTC_2895 9054447 58.44 µM -1.44397398836373 0.0625004180366466 no 3156 0.0743731461812576 4526 2697450 SGTC_3031 9088762 49.47 µM -1.44837872849728 0.0619252792502395 no 3157 0.0737555802325177 4440 205253 SGTC_1570 verbenone 133 µM -1.44877822470123 0.0618733209249718 no 3158 0.0736997633746653 4484 29025 A natural terpanoid with antifungal properties. SGTC_2391 6285546 200 µM -1.45103916421562 0.0615799049412458 no 3159 0.0733844774858858 4472 846083 SGTC_1498 4478-3555 97.6 µM -1.45311778434535 0.0613111094041829 no 3160 0.0730955270208952 4465 3437919 SGTC_757 1066-0008 322 µM -1.45819433994596 0.0606584908187673 no 3161 0.0723934917389711 4491 6842497 SGTC_1479 0549-0158 134 µM -1.46281223609824 0.0600695665080153 no 3162 0.0717593819878528 4528 5440202 SGTC_229 benomyl 22.8748 µM -1.4647696740493 0.0598212878538696 no 3163 0.0714918841727522 4482 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1879 gemcitabine 100 µM -1.46625413323157 0.0596335376956284 no 3164 0.0712895329730397 4433 60750 A nucleoside analog which inhibits DNA replication. SGTC_3078 9116413 49.47 µM -1.46646188288295 0.0596072989865517 no 3165 0.0712612490848492 4425 17177322 SGTC_181 1447-1644 8.07 µM -1.46649377599186 0.0596032716991294 no 3166 0.0712569077892905 4425 534600 SGTC_3110 9122132 49.47 µM -1.46655543750709 0.0595954860247736 no 3167 0.0712485149888154 4500 918317 SGTC_590 k048-0076 22.4 µM -1.47681301521173 0.0583113733395846 no 3168 0.0698628833846244 4497 6832814 SGTC_662 k832-1615 104 µM -1.4888967963663 0.0568266387467834 no 3169 0.0682572736556924 4503 5878478 SGTC_3229 9132204 49.47 µM -1.49004068045909 0.0566876464518417 no 3170 0.0681067699327284 4582 17682924 SGTC_1645 Cervolide 78 µM -1.49083601591887 0.0565911639173641 no 3171 0.0680022767061626 4505 23173 A fragrance. SGTC_3241 9133421 49.47 µM -1.49202710011007 0.0564469149390072 no 3172 0.0678460205402915 4580 17018221 SGTC_329 k048-0121 21.3 µM -1.49293787699668 0.0563368088521385 no 3173 0.0677267245788088 4494 6832902 SGTC_1669 st015249 58.4 µM -1.49299255194683 0.056330204451696 no 3174 0.0677195682683011 4606 722793 SGTC_1087 pterostilbene 9.05 µM -1.49977452461822 0.0555157059431366 no 3175 0.066836409236921 4502 5281727 Similar to reservatol, lowers cholesterol. SGTC_2351 9026858 72.31 µM -1.50144775410582 0.0553161918847 no 3176 0.0666198951569296 4380 1409300 SGTC_2802 7925815 54.55 µM -1.50151869452092 0.0553077455559952 no 3177 0.0666107275541583 4472 1262923 SGTC_1170 0310-0127 64.8 µM -1.50330275432692 0.055095666002251 no 3178 0.0663804950980605 4500 774975 SGTC_1411 3909-8223 150 µM -1.51167471032292 0.054109021194685 no 3179 0.0653083176353871 4534 X1411 SGTC_2440 5628896 157.78 µM -1.51338363151293 0.0539093518686096 no 3180 0.06509112016437 4477 5522048 SGTC_3053 9095903 49.47 µM -1.51519263226831 0.0536986253769501 no 3181 0.0648618141834565 4613 17174018 SGTC_159 3970-0959 50 µM -1.52611015333353 0.0524406843920314 no 3182 0.063491216937056 4525 6615653 SGTC_2405 ticlatone 3.52 µM -1.52678295534929 0.0523639344412075 no 3183 0.0634074956680685 4322 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2428 5615643 7.78 µM -1.52918889351508 0.0520902062978482 no 3184 0.0631088115683225 4499 2253075 SGTC_2164 5685496 200 µM -1.53024276708053 0.0519706636549046 no 3185 0.0629783245124532 4444 759046 SGTC_960 1222-0186 7.7 µM -1.54133731656393 0.0507253748410455 no 3186 0.0616173556312367 4508 3126296 SGTC_413 propylparaben 100 µM -1.54598008270046 0.0502113594069224 no 3187 0.0610546890492194 4505 7175 A pharmaceutical preservative. SGTC_3000 9075062 71.4286 µM -1.54601041877294 0.0502080145079786 no 3188 0.0610510258080378 4506 17057871 SGTC_2485 5633444 17.78 µM -1.54985657568827 0.0497853685315569 no 3189 0.0605879721236712 4490 5724239 SGTC_3280 9140961 49.47 µM -1.55409385702323 0.0493230336535674 no 3190 0.0600810151514922 4544 4901226 SGTC_2426 5582046 32.21 µM -1.55423709026167 0.0493074654031218 no 3191 0.0600639366466179 4506 2251934 SGTC_2240 6690706 185.951 µM -1.55621388274525 0.0490930051453044 no 3192 0.0598286206227358 4423 805876 SGTC_876 0720-0963 56.8 µM -1.56265318722646 0.0483995737852796 no 3193 0.059067095411601 4540 765861 SGTC_1925 st057770 10.1 µM -1.56268292223191 0.0483963899683809 no 3194 0.0590635966092354 4525 5989122 SGTC_1014 4130-3005 69.3 µM -1.56668358795147 0.0479695517132995 no 3195 0.0585943344231705 4534 743608 SGTC_1076 itraconazole 331 nM -1.57115049331642 0.0474965356192454 no 3196 0.0580738481697222 4539 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_836 0330-0104 1.35 µM -1.57420648062657 0.0471750846149765 no 3197 0.0577198608026534 4573 46494820 SGTC_1853 st056710 91.2 µM -1.57686419697975 0.0468969466057162 no 3198 0.0574133881213222 4567 269167 SGTC_1461 k072-0203 53.8 µM -1.57837276512677 0.0467396564999536 no 3199 0.0572399990901411 4420 5418714 SGTC_1646 st011709 75.6 µM -1.57892874379052 0.04668179450457 no 3200 0.0571762010607431 4504 5757843 SGTC_2157 5649910 96.377 µM -1.57975651461564 0.0465957529649796 no 3201 0.0570813188463297 4530 2858091 SGTC_2189 6047310 154.431 µM -1.58081183078005 0.0464862441245845 no 3202 0.0569605343197639 4533 711535 SGTC_1633 st005664 67.9 µM -1.5825566468922 0.0463056399402185 no 3203 0.0567612756974022 4514 2063822 SGTC_2037 5169046 200 µM -1.58724582555087 0.0458230582482284 no 3204 0.0562284898225478 4594 5718022 SGTC_964 1287-0107 19.4 µM -1.59407376862345 0.0451276041591874 no 3205 0.0554597566798042 4533 51516812 YPR165W RHO1 SGTC_1567 st069303 68.4 µM -1.59970017367904 0.044560936709297 no 3206 0.0548325566631711 4548 5581319 SGTC_1547 harmine 94.2 µM -1.60935969733756 0.0436014502137105 no 3207 0.0537688562683764 4465 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_21 0849-0113 22.993 µM -1.61368473888103 0.0431772792234653 no 3208 0.05329791292037 4541 1560156 SGTC_2282 7944268 200 µM -1.61796928984139 0.0427603717101592 no 3209 0.052834608070279 4531 2970414 SGTC_3088 9117578 49.47 µM -1.6190841343915 0.0426524271124971 no 3210 0.0527145809824785 4608 678341 SGTC_834 0312-0008 75.7 µM -1.62297155903992 0.0422777503758526 no 3211 0.0522977424122602 4579 6385573 YIL048W NEO1 SGTC_1308 1187-1617 41.4 µM -1.62552511172502 0.0420330868521963 no 3212 0.0520253587861445 4581 2882570 SGTC_463 ikarugamyin 104 µM -1.62802480226121 0.041794695344825 no 3213 0.0517598134104204 4698 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2984 9022109 38.96 µM -1.6281884152403 0.0417791300912067 no 3214 0.0517424702249801 4572 6459207 SGTC_843 0310-0051 143 µM -1.63584192238201 0.0410562471689829 no 3215 0.0509363377880493 4571 2065037 SGTC_422 cantharidin 155 µM -1.63649849821586 0.0409947081288404 no 3216 0.0508676498769099 4470 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1080 nisoldipine 24.4 µM -1.63775648344508 0.0408770096426166 no 3217 0.050736251328001 4581 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3276 9139060 49.47 µM -1.64119671178348 0.0405565375106932 no 3218 0.0503782940415519 4635 4870619 SGTC_416 estradiol valerate 100 µM -1.64162666666082 0.0405166291238932 no 3219 0.050333698870541 4544 13791 A steroid. SGTC_3256 9138902 49.47 µM -1.64671612387213 0.0400466439726444 no 3220 0.0498082042348686 4670 17228773 SGTC_2486 5283202 22.39 µM -1.64694118964755 0.0400259630194829 no 3221 0.0497850672629799 4568 1377751 SGTC_1534 6-azauridine 81.6 µM -1.64714513581727 0.0400072302108701 no 3222 0.0497641088117516 4608 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_676 falcarinol 140 µM -1.6485711988298 0.0398764428468608 no 3223 0.0496177565992873 4585 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_947 3447-0010 211 µM -1.64872892053191 0.0398619992121141 no 3224 0.0496015912493326 4516 748350 SGTC_638 3970-0837 4.09 µM -1.65043725524169 0.0397058278569135 no 3225 0.0494267682874937 4557 4118451 YLR208W SEC13 SGTC_1102 cgs 12066b 26.1 µM -1.65245299417351 0.0395221946487698 no 3226 0.0492211199969961 4593 6438352 A 5-HT1B full agonist. SGTC_2822 7994718 71.43 µM -1.65254205476522 0.03951409721715 no 3227 0.0492120497057272 4572 1018011 SGTC_1904 st060225 78 µM -1.65759971657562 0.0390564619344651 no 3228 0.0486991434634227 4561 66595 SGTC_424 splitomicin 100 mM -1.66120471675291 0.0387329099168336 no 3229 0.0483361692998713 4558 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1155 4088-0394 48.2 µM -1.66771063729793 0.0381545254887353 no 3230 0.0476865913759075 4580 2326248 SGTC_1057 3448-5381 134 µM -1.6688771009136 0.0380515738712492 no 3231 0.0475708693194419 4557 5497911 SGTC_3005 9076496 71.4286 µM -1.68013096153483 0.0370699073469096 no 3232 0.0464659190298741 4541 21368410 SGTC_235 0330-0087 5 mM -1.68082821671029 0.03700977358471 no 3233 0.0463981430991281 4621 46494818 YHR062C RPP1 SGTC_1730 st033808 45.1 µM -1.68285430321427 0.0368354890501082 no 3234 0.0462016498355781 4512 1045166 SGTC_2423 st077119 87.2 µM -1.68464161843506 0.03668230136622 no 3235 0.0460288682977322 4510 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1105 epirubicin 18.1 µM -1.68515210260167 0.0366386444497893 no 3236 0.045979614701094 4616 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3172 9105863 49.47 µM -1.68954836720708 0.0362644297467035 no 3237 0.0455571955573583 4690 2348785 SGTC_1335 1486-0900 202 µM -1.69015594347262 0.0362129591720548 no 3238 0.0454990622341177 4594 X1335 SGTC_2279 7948423 32.93 µM -1.69285755472996 0.0359848170422764 no 3239 0.0452412921276056 4519 1247112 SGTC_2904 7225135 42.03 µM -1.69645167609241 0.0356831316695665 no 3240 0.0449001871860718 4650 4446116 SGTC_2733 amorolfine 100 µM -1.6991182426179 0.0354606460014215 no 3241 0.0446484534014801 4732 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2387 9077560 195.08 µM -1.70339771597925 0.035105965519988 no 3242 0.0442468324284056 4587 5303272 SGTC_2726 cimetidine 79.27 µM -1.70356916521868 0.0350918167648805 no 3243 0.0442308030883612 4608 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2066 5222451 176 µM -1.72262676937953 0.0335480216515628 no 3244 0.0424780204370413 4542 2281147 SGTC_2808 7946468 45.46 µM -1.72386885107033 0.0334493763334112 no 3245 0.0423657608288181 4567 2970879 SGTC_2635 hydroquinidine 100 µM -1.72422445735768 0.033421178327018 no 3246 0.042333665284036 4534 442912 An experimental heart treatment. SGTC_949 1165-0505 146 µM -1.72503643724057 0.0333568652751375 no 3247 0.0422604530897098 4576 6244267 SGTC_840 0245-0196 390 µM -1.72519363173869 0.0333444264310388 no 3248 0.042246291485013 4662 3827528 SGTC_2244 6635614 200 µM -1.73154829890654 0.0328447693468674 no 3249 0.0416770091406425 4539 836499 SGTC_1412 3909-8563 178 µM -1.73358743792266 0.0326857492645695 no 3250 0.0414956554799869 4676 23767530 SGTC_1002 4049-0206 172 µM -1.73840558900779 0.0323125320694718 no 3251 0.0410696862948245 4577 4662749 SGTC_3304 9125678 46.087 µM -1.7400061019509 0.0321893361324882 no 3252 0.0409289732543392 4552 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2732 terfenadine 20 µM -1.74296620028029 0.031962510788392 no 3253 0.0406697595155058 4675 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_582 0987-0078 156 µM -1.75065392992242 0.0313795779221278 no 3254 0.0400027698176138 4642 1625765 SGTC_841 0251-0215 91.2 µM -1.75226335739379 0.0312586603457634 no 3255 0.0398642668452345 4644 3888614 SGTC_1274 0865-0114 173 µM -1.75402779510596 0.0311265398079738 no 3256 0.0397128722908522 4616 870624 SGTC_1072 oxiconazole 14.9 nM -1.75621849365648 0.0309631442071758 no 3257 0.0395255540484087 4589 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3023 9089636 49.47 µM -1.75953362966301 0.0307172315764245 no 3258 0.039243456696973 4671 17249241 SGTC_1446 4239-0190 62 µM -1.75954684177091 0.0307162547636163 no 3259 0.0392423357159437 4626 1340085 SGTC_1336 1486-0901 104 µM -1.76376151097713 0.0304059611138543 no 3260 0.0388860700546013 4609 5006114 SGTC_124 0136-0217 7.121 µM -1.77109831388973 0.0298720058368152 no 3261 0.0382721771817568 4659 3976905 SGTC_1241 0364-0022 50.8 µM -1.77132852235393 0.0298553784659451 no 3262 0.0382530435377894 4624 4563895 SGTC_2433 5607874 27.82 µM -1.77286365215574 0.0297446961389106 no 3263 0.0381256514515712 4576 2252428 SGTC_3035 9091303 49.47 µM -1.78533943042862 0.0288577645407586 no 3264 0.0371031383853081 4662 25237002 SGTC_641 4092-0595 30 µM -1.79529849404005 0.0281656308393692 no 3265 0.0363030774306158 4659 786260 SGTC_3325 9138760 55.175 µM -1.79676791758279 0.0280646886527924 no 3266 0.0361862357940965 4573 43844959 SGTC_1109 tnp00067 928.257 nM -1.80362546856061 0.0275975837229407 no 3267 0.0356450203422086 4618 676295 SGTC_514 4466-0038 2.65 nM -1.81625386769884 0.0267543488654176 no 3268 0.034665719153126 4439 5722064 SGTC_2257 7960413 200 µM -1.81866351263351 0.0265959193337478 no 3269 0.0344813908056586 4660 2974689 YIL048W NEO1 SGTC_970 1315-0089 19.5 µM -1.82399117284885 0.0262484165230685 no 3270 0.0340767033724105 4612 6811083 YLR033W RSC58 SGTC_2937 9044753 11.33 µM -1.82465722977166 0.0262052403425069 no 3271 0.0340263856549607 4569 6465530 YGL099W LSG1 SGTC_1662 st014054 52 µM -1.83500713779112 0.0255419177547847 no 3272 0.0332523159333062 4698 2838777 SGTC_2264 7948757 110.76 µM -1.83869967163868 0.0253086928385273 no 3273 0.0329796858742318 4594 2971411 SGTC_612 0302-0167 22.4 µM -1.84773796571856 0.0247453420843469 no 3274 0.0323201294345538 4631 235821 SGTC_598 3937-0236 20.2 µM -1.85257100402861 0.0244484433863551 no 3275 0.0319719358457737 4689 1379313 SGTC_576 1073-0113 22.7 µM -1.85549847652357 0.0242700640684992 no 3276 0.0317625382895222 4683 5439563 SGTC_2171 5739187 198.077 µM -1.86998234812834 0.0234035228954862 no 3277 0.0307431345775991 4617 2262761 SGTC_1768 st044301 37.178 µM -1.87050627529684 0.0233726716714996 no 3278 0.0307067731952906 4663 3931349 SGTC_1218 1348-1416 30.7 µM -1.87641488698257 0.0230271087087842 no 3279 0.0302991659744634 4638 6787668 SGTC_3079 9117512 49.47 µM -1.87770447286494 0.0229522625461403 no 3280 0.0302108022485536 4715 7185044 SGTC_1876 myriocin 605 nM -1.87853717831136 0.0229040421906918 no 3281 0.0301538580055625 4634 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1899 st063254 59.6 µM -1.88112436674647 0.0227547673066048 no 3282 0.0299775015388882 4624 3093813 SGTC_2445 5742597 35.57 µM -1.88144519637915 0.022736313434044 no 3283 0.029955691824036 4654 1774255 SGTC_3355 9151058 44.0485 µM -1.8852473235223 0.0225185767911784 no 3284 0.0296982271822749 4662 17015728 SGTC_814 3342-0569 96 µM -1.88872952494491 0.0223207064660052 no 3285 0.0294640401523141 4677 4346283 SGTC_1369 1866-0067 208 µM -1.89574816265898 0.0219263391987413 no 3286 0.0289966766825016 4651 3531355 SGTC_2357 9067248 200 µM -1.89651111070478 0.0218838269485461 no 3287 0.0289462461060297 4611 9150235 SGTC_2734 clemastine 41.6 µM -1.90305376687767 0.0215221131888758 no 3288 0.028516764906404 4724 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3163 9099914 49.47 µM -1.91354701276494 0.0209525449311688 no 3289 0.0278390305019005 4729 16268368 SGTC_2783 7738165 71.43 µM -1.91632631056992 0.0208038408045873 no 3290 0.0276617869647954 4650 17201110 SGTC_2755 lomerizine 42.69 µM -1.92124436195774 0.020542893733222 no 3291 0.027350453909107 4606 3949 A calcium channel blocker. SGTC_1307 1187-1599 12.2 µM -1.9293564202965 0.0201185358759496 no 3292 0.0268433149698898 4685 1538471 SGTC_1443 4112-3303 14 µM -1.93018264764174 0.0200757344579406 no 3293 0.0267921054070317 4708 704433 SGTC_476 mead acid 10 µM -1.93098312250719 0.0200343407922939 no 3294 0.0267425698104047 4714 5312531 An omega 9 fatty acid. SGTC_1892 st058411 7.36 µM -1.94710296433913 0.0192160442757158 no 3295 0.0257611958505926 4663 3934738 SGTC_2355 9061122 103.12 µM -1.94847979522841 0.0191474878307301 no 3296 0.0256787900575714 4676 5302957 SGTC_1462 k081-0014 26.5 µM -1.94881781678052 0.0191306885738083 no 3297 0.0256585926339533 4108 3270634 SGTC_518 1021-0119 62.6 µM -1.95710271428799 0.0187228397331984 no 3298 0.0251676966920221 4639 1097762 SGTC_3352 9151559 45.5865 µM -1.96503782504294 0.0183391716108534 no 3299 0.0247049299073858 4677 17159339 SGTC_2276 7947513 42.08 µM -1.96944048644416 0.018129203491451 no 3300 0.0244512652019165 4604 2105100 SGTC_1047 2043-3044 82 µM -1.97245363145975 0.0179866870348121 no 3301 0.0242789223063107 4647 669592 SGTC_139 0099-0334 718.624 µM -1.97849954562711 0.0177036056677497 no 3302 0.0239361898986384 4666 97690 SGTC_1214 0358-0031 63.7 µM -1.99004923115429 0.0171733859234034 no 3303 0.0232927562850955 4669 4301366 SGTC_1175 0741-0056 27.6 µM -1.99671150599631 0.016873751897256 no 3304 0.0229282657470828 4706 765927 SGTC_421 streptovitacin 30 mM -2.00362586139215 0.0165675195322353 no 3305 0.0225550767133757 4665 91467 include heat shock SGTC_1377 2944-0135 198 µM -2.00525896220727 0.0164958889375473 no 3306 0.0224676847839049 4674 1894137 SGTC_2580 diallyl disulphide 81.36 µM -2.0054884512458 0.0164858444313319 no 3307 0.0224554270768373 4648 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_257 daunorubicin 18.5 µM -2.00878781207452 0.0163420124486953 no 3308 0.0222798206743558 4708 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3335 9143315 29.6265 µM -2.00907006517193 0.0163297579885535 no 3309 0.0222648518761712 4684 4899691 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -2.02121509496067 0.0158098657752468 no 3310 0.0216287518892377 4652 364106 SGTC_1780 st038448 24.544 µM -2.02328690602739 0.0157226101360619 no 3311 0.0215217880442488 4691 728868 YDL195W SEC31 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -2.02721936665755 0.0155581278763625 no 3312 0.0213199917073399 4654 6857784 SGTC_2903 5923464 63.88 µM -2.04817754156285 0.0147062056547954 no 3313 0.0202713030963156 4705 2876576 SGTC_1557 sumaresinolic acid 42.3 µM -2.05146155164224 0.0145764193817194 no 3314 0.0201110101014448 4676 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_515 4092-1064 102 µM -2.0609700838955 0.0142061802813487 no 3315 0.0196529471198585 4660 717353 SGTC_2893 9048488 25.97 µM -2.06874690863791 0.0139094200232995 no 3316 0.0192849214137602 4706 6467338 SGTC_1049 3226-0134 66 µM -2.07591952644512 0.0136404698180641 no 3317 0.0189506972157535 4702 5702385 SGTC_3184 9108758 49.47 µM -2.11353333854352 0.0123023545819983 no 3318 0.0172775723243373 4757 902885 SGTC_1193 1488-0126 41.5 µM -2.11380697475508 0.0122930523084018 no 3319 0.0172658785073297 4693 1384710 SGTC_483 fpl-64176 144 µM -2.13047011795441 0.0117379540208379 no 3320 0.0165664101489094 4779 3423 SGTC_771 0250-0039 27.3 µM -2.13702765161776 0.011525543601621 no 3321 0.0162978713177202 4676 3005115 SGTC_2832 7992762 51.95 µM -2.14373685140171 0.011311683328006 no 3322 0.0160269888419944 4632 2985177 SGTC_1575 cyproterone acetate 48 µM -2.1442858769759 0.0112943364099457 no 3323 0.0160049938636389 4684 9880 An androgen receptor antagonist and liver toxin. SGTC_3227 9130768 49.47 µM -2.15913069070139 0.0108339864690576 no 3324 0.0154200146202094 4754 17720899 SGTC_1126 isoteolin 1.0172 µM -2.17630522679012 0.0103218452992878 no 3325 0.0147662224890872 4680 133323 SGTC_409 arachidonic acid 100 µM -2.17807707852578 0.0102702300251257 no 3326 0.014700149385743 4726 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1161 k007-0610 110 µM -2.18041656636485 0.0102024240027858 no 3327 0.014613298622786 4656 5843850 SGTC_1046 2001-0062 216 µM -2.19176962853237 0.00987889165222411 no 3328 0.0141980725907931 4696 739778 SGTC_2939 9044578 71.43 µM -2.20569043094355 0.00949444119632921 no 3329 0.01370284118874 4674 2653634 SGTC_1723 st034307 2.5525 µM -2.20664239206306 0.00946863539918033 no 3330 0.013669526423867 4702 867466 SGTC_1752 st044819 83.042 µM -2.24682039602556 0.00843395393416166 no 3331 0.0123257538642447 4688 441209 YML126C ERG13 SGTC_230 MPP+ 141.667 µM -2.24830849111051 0.0083976161126267 no 3332 0.0122782628275935 4732 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_810 3825-7150 143 µM -2.26679913819598 0.00795742709162488 no 3333 0.0117012494034268 4726 22330411 YGL099W LSG1 SGTC_2444 5485484 36.41 µM -2.30158357516375 0.007184053854349 no 3334 0.0106793336392587 4752 6790631 SGTC_1174 0739-0097 51.1 µM -2.32600748878715 0.00668140799713457 no 3335 0.0100090755888089 4763 728447 SGTC_504 lovastatin 124 µM -2.33834746765344 0.00643947305604602 no 3336 0.00968461524515057 4730 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_196 k015-0023 18.111 µM -2.34118832433168 0.00638488580733791 no 3337 0.00961123410174276 4731 5211998 SGTC_2070 5230947 200 µM -2.35637787857755 0.00609990946630798 no 3338 0.00922706719591063 4773 2835538 SGTC_1424 4048-1941 275 µM -2.39770885228989 0.00538073160157818 no 3339 0.00824898638353053 4776 X1424 SGTC_2533 agelasine 13.65 µM -2.40082646138094 0.00532967285666876 no 3340 0.00817904605572624 4744 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2178 5812956 200 µM -2.41777882576989 0.00505950427338536 no 3341 0.00780778258309079 4736 5403383 SGTC_2838 9002687 71.43 µM -2.45477218479557 0.00451187126959229 no 3342 0.00704869483925858 4728 6457060 SGTC_1500 4488-1866 171 µM -2.50162103558928 0.00389461259779655 no 3343 0.00618130883669483 4789 2900003 SGTC_759 3486-0358 89.3 µM -2.53405993153025 0.0035127108224514 no 3344 0.00563747232183517 4755 875103 SGTC_1816 st051957 91.6 µM -2.55206094368151 0.00331561553352431 no 3345 0.00535438926246858 4770 674121 SGTC_2337 9009472 200 µM -2.57941745031074 0.00303508525619507 no 3346 0.00494835545972375 4719 5742383 SGTC_1237 0330-0133 46.1 µM -2.59806456951189 0.00285631463615836 no 3347 0.00468754315552867 4748 X1237 YHR072W ERG7 SGTC_272 doxorubicin 8.13 µM -2.75121257511742 0.00171113672640849 no 3348 0.00296875497430849 4785 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2173 5763948 167 µM -2.77105255973062 0.00159835950094144 no 3349 0.00279377033790806 4784 2867177 SGTC_1635 st007035 42.4 µM -2.83215609924629 0.00129225559050903 no 3350 0.00231176355970517 4755 3716403 SGTC_474 dl-dihydrosphingosine 5 µM -3.07560632544725 0.000532682098651183 yes 3351 0.00105037506148433 4787 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2830 7992007 71.43 µM -3.26783236186823 0.000253062522422005 yes 3352 0.000541872682222287 4763 1952075 SGTC_2475 5812728 15.03 µM -3.33632911566321 0.000192265392457594 yes 3353 0.000424463000476055 4786 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1626 st003712 1.76 µM -3.37128864636487 0.00016678506822194 yes 3354 0.000374087112504648 4795 24207035 SGTC_1425 4048-4433 7.33 µM -3.37902165244023 0.000161593011332835 yes 3355 0.000363721392920757 4805 23734946 SGTC_3206 9114350 49.47 µM -3.76580681416519 3.06045299841439e-05 yes 3356 8.30060604058316e-05 4775 17087243