SGTCid condition conc unit RPS16A|YMR143W.score RPS16A|YMR143W.strain.pval RPS16A|YMR143W.strain.significant RPS16A|YMR143W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1457 k015-0032 57.3 µM 6.2029927354897 8.6523185290023e-10 yes 1 2.76996988717067e-10 5 4302660
SGTC_1107 amlodipine 47 µM 5.64913748214109 2.04634824129685e-08 yes 2 8.06274281758378e-09 6 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_940 3232-1287 54.8 µM 5.60576460189541 2.59100421674322e-08 yes 3 1.03668799881226e-08 10 1585493 YIL048W NEO1
SGTC_2688 kanamycin b 96.69 µM 5.24815873417582 1.69953777900152e-07 yes 4 7.68134519581161e-08 225 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_3052 9092717 49.47 µM 4.97090459081701 6.74799111330939e-07 yes 5 3.33206197730682e-07 12 25237534
SGTC_2908 7930301 100 µM 4.9511959158345 7.42334684517946e-07 yes 6 3.68794009946863e-07 9 2223178
SGTC_1223 0764-0573 147 µM 4.94205896332855 7.75805901546304e-07 yes 7 3.86509139532732e-07 6 1609797
SGTC_2251 lansoprazole 556 µM 4.78317174543028 1.65049175315735e-06 yes 8 8.62752859739968e-07 10 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1991 st073000 8.92 µM 4.72957619615322 2.11830031373238e-06 yes 9 1.12494501688635e-06 59 4301969 YIL048W NEO1
SGTC_560 2332-1943 155 µM 4.53212832584774 5.19517608441389e-06 yes 10 2.919617875912e-06 2 21177716
SGTC_942 3253-1115 227 µM 4.33484808289091 1.22960938491556e-05 yes 11 7.29304089271433e-06 20 46497897
SGTC_2122 5258151 111.688 µM 4.30694001209232 1.38509982152379e-05 yes 12 8.27642383994864e-06 19 2173356
SGTC_3117 9124945 49.47 µM 4.1765599260743 2.39379395695669e-05 yes 13 1.47975400540256e-05 2 17592065
SGTC_1932 st074806 40.9 µM 4.1541941831106 2.62534564920866e-05 yes 14 1.63217938153719e-05 21 17251235
SGTC_497 capsazepine 133 µM 4.1212988578261 3.00478974475225e-05 yes 15 1.88371159473725e-05 9 2733484 A calcium channel blocker.
SGTC_3140 9094243 49.47 µM 4.09123035949337 3.39655398610963e-05 yes 16 2.14545323024356e-05 21 19291112
SGTC_1982 st072467 71.9 µM 3.97216062617701 5.47500147554839e-05 yes 17 3.56118327727117e-05 35 3163533
SGTC_625 k213-0058 121 µM 3.93299084768412 6.3885353820067e-05 yes 18 4.1947716613258e-05 105 3655420
SGTC_2700 st077718 96.8 µM 3.92700706458072 6.54014326574839e-05 yes 19 4.3004727907841e-05 14 904970
SGTC_2909 7941780 10.49 µM 3.9177174109495 6.78224407268895e-05 yes 20 4.46957057651059e-05 20 1243215
SGTC_1017 4239-0030 168 µM 3.83608703438656 9.3039032094878e-05 yes 21 6.25050609544615e-05 33 1149593
SGTC_1720 st037298 9.481 µM 3.74216953502617 0.000132880452131013 yes 22 9.12191813727565e-05 38 597396
SGTC_118 0083-0097 135.343 µM 3.73982992444624 0.000134052261296906 yes 23 9.20724035645594e-05 159 5207356
SGTC_1985 st071382 65.5 µM 3.71707687771264 0.000145964530636802 yes 24 0.000100770565168013 26 6123237
SGTC_2906 7926292 26.41 µM 3.70768417959848 0.00015116543700273 yes 25 0.000104581641787561 33 2966319
SGTC_71 0417-1750 47.813 µM 3.68760732329285 0.000162869725597317 yes 26 0.000113186313179392 55 6811472
SGTC_1925 st057770 10.1 µM 3.61810108564961 0.000210270197031193 yes 27 0.000148386244814886 28 5989122
SGTC_2239 6685329 187.64 µM 3.59274104013481 0.000230565896019338 yes 28 0.000163608867547817 41 805680
SGTC_56 0957-0365 83.25 µM 3.57628523195742 0.000244698085396904 yes 29 0.000174255692431637 61 6752360
SGTC_2114 5491910 81.25 µM 3.46398587723984 0.000364909759943411 yes 30 0.000266117226297754 27 2849228
SGTC_830 4076-0286 57.8 µM 3.46207315772091 0.00036736684261803 yes 31 0.000268015714266174 88 6866659
SGTC_2396 5342950 42.78 µM 3.46084791658622 0.000368948854940979 yes 32 0.000269238462011899 71 1886677
SGTC_800 3448-7362 155 µM 3.42474360813566 0.000418506196067661 yes 33 0.0003076899335194 207 15991913
SGTC_2097 5376186 200 µM 3.40685494563294 0.000445285384817044 yes 34 0.000328580208933362 37 742755
SGTC_2321 7390090 138.78 µM 3.36884875102899 0.000507533345212063 yes 35 0.000377414185513537 51 649046
SGTC_3235 9132602 49.47 µM 3.36384589404792 0.000516302163400315 yes 36 0.000384322250159238 46 4912240
SGTC_2730 imipramine 71.33 µM 3.3395942243474 0.000560831306956985 yes 37 0.000419504416330231 47 3696 A tricyclic antidepressant.
SGTC_708 3448-5400 146 µM 3.32118585746834 0.000596973472633428 yes 38 0.00044817912768107 70 3462195
SGTC_1313 1220-0047 237 µM 3.25091553444668 0.000755633924143955 yes 39 0.000575170140246759 71 3528706
SGTC_2780 5215298 71.43 µM 3.24807115022185 0.000762808063153238 yes 40 0.000580951061638193 75 2834131
SGTC_15 0266-0086 27.098 µM 3.24414759643446 0.000772807079137101 yes 41 0.000589013432403855 99 1712902 YIL048W NEO1
SGTC_1480 1070-0044 41.2 µM 3.24138127587813 0.000779929335349323 yes 42 0.000594759853849807 38 3124987
SGTC_957 1187-1561 14.1 µM 3.20528006121412 0.000878586705487729 yes 43 0.00067465561337082 53 1538454
SGTC_309 k408-0051 1.48 µM 3.19395911271072 0.000911811461124535 yes 44 0.000701679959919758 103 3640463
SGTC_1931 st074438 57.1 µM 3.18135638058829 0.000950153501921942 yes 45 0.000732935918812812 44 2787313
SGTC_1505 k297-0037 20.6 µM 3.17350885705048 0.000974770852585068 yes 46 0.000753041532651976 46 4089396
SGTC_2751 anetholtrithion 17.25 µM 3.15209946924742 0.00104493926867959 no 47 0.000810505213224633 61 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2265 7929201 200 µM 3.14510795860796 0.00106883847171338 no 48 0.000830127752605752 56 1265108
SGTC_1228 0124-0032 52.5 µM 3.12856154156898 0.00112740924066371 no 49 0.000878321102549404 53 X1228
SGTC_2802 7925815 54.55 µM 3.12435435876602 0.00114276348633412 no 50 0.000890978563198438 76 1262923
SGTC_2849 9019321 12.99 µM 3.11146670090334 0.00119099726518307 no 51 0.000930802340882988 64 16489627
SGTC_961 1252-1571 372 µM 3.04904205730003 0.00145208905006367 no 52 0.00114786170091757 61 6813498
SGTC_2104 5389443 200 µM 3.01433600981728 0.00161889618224249 no 53 0.00128771199668133 53 2244536
SGTC_450 aminopyrene 156 nM 3.00848337320956 0.00164868750418234 no 54 0.0013127758413995 84 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1768 st044301 37.178 µM 3.00474023404091 0.00166800191147616 no 55 0.00132903877945056 59 3931349
SGTC_2658 polymyxin b sulfate 77.05 µM 2.99915217839689 0.00169721962763576 no 56 0.00135366023048699 84 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1360 1598-0022 39.8 µM 2.98331942302358 0.00178255098662358 no 57 0.0014257011918313 92 761525
SGTC_1487 3970-0795 2.82 µM 2.9495022166122 0.00197801902960476 no 58 0.00159143144897254 54 3765103
SGTC_1503 4585-0012 61.3 µM 2.94060812141544 0.00203256362092066 no 59 0.00163784329172716 58 2922052
SGTC_1893 st059353 36.1 µM 2.82803026455708 0.00285115911858426 no 60 0.00234176892942921 78 3112488
SGTC_2102 5377816 72.7585 µM 2.80978728311264 0.00300880169791846 no 61 0.00247871266543798 80 1379702
SGTC_503 tyrphostin 8 294 µM 2.80691426731808 0.00303433166403586 no 62 0.00250092759028893 90 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1844 rapamycin 4 nM 2.80644432652024 0.00303852613437767 no 63 0.00250457838150972 264 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_549 1661-1316 519 µM 2.79254480504124 0.00316497251145324 no 64 0.00261476123438094 73 2857282
SGTC_1074 carmofur 3.8 µM 2.79112878332769 0.00317811650354967 no 65 0.00262622845174309 99 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1550 gossypolone 36.6 µM 2.7847830451749 0.00323762514629137 no 66 0.00267817745080003 72 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1159 4092-0538 61.2 µM 2.78319114970141 0.00325270992543735 no 67 0.00269135415987567 88 717301
SGTC_1149 3909-7961 23.3 µM 2.75501328898966 0.00353039460876031 no 68 0.00293448758311574 104 735261
SGTC_3050 9093513 49.47 µM 2.71456479784306 0.0039662366632659 no 69 0.00331814581355354 80 25236664
SGTC_791 1348-1292 225 µM 2.71408214365771 0.00397171624539529 no 70 0.00332298422281414 131 5437054
SGTC_679 0422-0091 41.4 µM 2.68662076077326 0.00429487438019399 no 71 0.00360894258404061 111 627384 YHR062C RPP1
SGTC_2020 4017018 200 µM 2.665349691887 0.00456113205884934 no 72 0.00384541517424132 92 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_832 4083-0019 164 µM 2.62084589817871 0.00516635592367261 no 73 0.00438559499909554 255 1990758
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 2.61926758632208 0.00518907475915522 no 74 0.00440593978216635 134 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_3096 9117468 49.47 µM 2.60568239647966 0.00538833035058086 no 75 0.00458457198613943 45 41316311
SGTC_2938 9059746 27.26 µM 2.5807344708971 0.00577202511703934 no 76 0.00492951902093637 128 6471769
SGTC_1319 1306-0155 43.7 µM 2.57782851674485 0.00581825866657438 no 77 0.00497116621557072 140 3122360
SGTC_2589 lobaric acid 100 µM 2.56889313101597 0.00596248512528764 no 78 0.00510119577467269 123 73157 A novel microtubule depolymerizer.
SGTC_2142 5622915 118.518 µM 2.55964051186735 0.00611516414040015 no 79 0.00523902440866592 71 5322196
SGTC_364 0083-0097 67.7 µM 2.55737683043741 0.00615304091517608 no 80 0.00527324498324286 120 5207356
SGTC_1729 st035615 45.989 µM 2.54864706641223 0.0063010640103508 no 81 0.00540708398546574 127 17385451
SGTC_1350 1495-0454 146 µM 2.54744989758724 0.00632160726217406 no 82 0.00542567170266944 135 1069057
SGTC_2785 7756463 72.73 µM 2.51022098805807 0.00699075653215098 no 83 0.00603278140993439 111 2201551
SGTC_277 nystatin 15.5 µM 2.49033376613251 0.00737322530933552 no 84 0.00638115910128784 119 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_686 1319-0111 510 µM 2.48586625309024 0.00746163912786513 no 85 0.00646182630708193 116 4562600
SGTC_357 1325-0123 420 µM 2.45262295241705 0.00814938513318453 no 86 0.00709094518673787 85 1098503
SGTC_1984 st072354 53.1 µM 2.44858030338271 0.00823670731340719 no 87 0.00717102278666401 101 5762938
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 2.44782268261998 0.00825316323854999 no 88 0.00718611832549452 127 94937 An inhibitor of serotonin biosynthesis.
SGTC_1051 3253-3903 78 µM 2.44373873767655 0.00834236700025676 no 89 0.00726797435660085 146 5509239
SGTC_831 k061-1017 217 µM 2.44164384143657 0.00838845252842025 no 90 0.00731028130387136 236 1240153
SGTC_1971 st069429 63.5 µM 2.42603584740793 0.00873890382306741 no 91 0.00763238120437577 105 1246522 YGL099W LSG1
SGTC_1162 k048-0130 20.1 µM 2.4126496871163 0.00904962680982917 no 92 0.0079185164617166 107 6797406
SGTC_3271 9137798 49.47 µM 2.39836982474275 0.0093917199507465 no 93 0.00823411442617825 76 6498326
SGTC_671 0560-0003 407 µM 2.39017025198866 0.00959322072289259 no 94 0.00842028206368504 114 3238678
SGTC_2160 5660466 132.927 µM 2.37668572959487 0.00993281864099683 no 95 0.00873448222923903 114 2859134
SGTC_583 1488-1091 88.9 µM 2.37452766791267 0.00998813106804726 no 96 0.00878570962706666 143 4303273
SGTC_2185 6113692 200 µM 2.3732726110039 0.0100204224295696 no 97 0.00881562274260938 111 874150
SGTC_2068 5226020 147 µM 2.37245329847238 0.0100415516462953 no 98 0.0088351984212058 178 1810509
SGTC_2489 cantharidin 73.42 µM 2.35156877867296 0.0105934275011443 no 99 0.00934721658078245 199 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1824 st053723 68.6 µM 2.34571104915432 0.0107528874704868 no 100 0.00949541181494715 159 675225
SGTC_246 cycloheximide 667 µM 2.34396201395214 0.0108009033367467 no 101 0.00954005726779191 103 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2706 st078239 82.5 µM 2.33757101044386 0.0109779446581891 no 102 0.00970475662527627 126 15434492
SGTC_1164 k060-0068 93.7 µM 2.33097030498335 0.0111634401320125 no 103 0.0098774627763503 166 5963676
SGTC_1363 1636-0063 10.4 µM 2.32465960248705 0.0113433281043142 no 104 0.0100450845090412 163 6072185
SGTC_445 e6 berbamine 66 µM 2.30822569482913 0.0118236474220727 no 105 0.0104932933750814 301 6610268 A calcium/calmodulin antagonist.
SGTC_2243 6634756 200 µM 2.27258865338456 0.0129261973151109 no 106 0.0115254900219355 131 885676
SGTC_3346 9158254 43.5805 µM 2.27102654921204 0.0129764957985272 no 107 0.0115726854026293 151 17639500
SGTC_2391 6285546 200 µM 2.26691547847643 0.0131096783831882 no 108 0.0116976947421071 177 846083
SGTC_335 4077-0256 27.6 µM 2.26532654955377 0.01316146909366 no 109 0.011746323987715 157 3121989
SGTC_1781 st038725 66.3 µM 2.23532840281354 0.014172951966469 no 110 0.0126978983563223 270 4270275 YIL048W NEO1
SGTC_1910 st062352 60.4 µM 2.22641709749324 0.0144860420604214 no 111 0.0129931281520836 194 2245730
SGTC_2176 5809774 33.9695 µM 2.2239368039574 0.0145742369021706 no 112 0.0130763482135379 138 2870539
SGTC_1880 MG-132 525 µM 2.21865096364389 0.0147637348427377 no 113 0.0132552397486495 133 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_115 0527-0192 112.043 µM 2.21535890539763 0.0148828233177747 no 114 0.0133677198185832 281 4233931
SGTC_2972 9093619 59.92 µM 2.21453365269016 0.014912805554742 no 115 0.0133960451843381 172 25236256
SGTC_505 gw-5074 63.9 µM 2.19852857216632 0.0155046388871839 no 116 0.0139557303757985 197 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_353 1988-1175 58.3 µM 2.19812259658439 0.0155199094859469 no 117 0.01397018532441 155 2788357
SGTC_3094 9117742 49.47 µM 2.19283065711994 0.0157201473601737 no 118 0.0141597911283594 202 17149698
SGTC_2583 asiatic acid 100 µM 2.18694115066562 0.0159455979019409 no 119 0.0143734101798931 177 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1394 3474-0001 65.7 µM 2.17441891595898 0.0164341760972824 no 120 0.0148368443830116 156 5017666 YIL048W NEO1
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 2.17338152185405 0.0164752208026163 no 121 0.0148758071981122 185 5106787 A p450 inhibitor.
SGTC_1055 3448-0672 86 µM 2.17197949711138 0.0165308316136528 no 122 0.0149286047164771 191 748378
SGTC_59 0330-0160 1.33 µM 2.16970689323853 0.0166213149221388 no 123 0.0150145287616496 355 4293482
SGTC_1145 3546-0597 10.2 µM 2.16468839733258 0.0168226277521049 no 124 0.0152057781121649 193 875334
SGTC_3006 9075424 71.4286 µM 2.16179955881796 0.0169394541221444 no 125 0.0153168147585255 170 7465181
SGTC_2610 ononetin 44.17 µM 2.16104778296148 0.0169699698960901 no 126 0.0153458242661987 241 259632
SGTC_2341 7987486 176.74 µM 2.15302590709966 0.0172985275074791 no 127 0.0156583212624049 210 1258686
SGTC_1970 st070122 35.8 µM 2.15170452602523 0.01735316618924 no 128 0.0157103167249212 188 102928
SGTC_465 cgp-37157 41 µM 2.14725231216078 0.0175383500768006 no 129 0.0158866000441084 103 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2512 diallyl trisulfide 49.23 µM 2.14348022814736 0.0176965624605959 no 130 0.0160372785252102 115 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1092 toremifene 6.32 µM 2.14074339766421 0.0178121141881845 no 131 0.0161473683750535 212 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3352 9151559 45.5865 µM 2.13731699463241 0.0179576871406868 no 132 0.0162861087578355 169 17159339
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 2.12647282371363 0.0184251129811797 no 133 0.0167319548718459 206 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2123 5259487 200 µM 2.12532751769495 0.018475079780752 no 134 0.0167796468416952 186 2173474
SGTC_1127 asiatic acid 681.4 nM 2.11918978044136 0.0187448242278153 no 135 0.0170372158062625 201 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_230 MPP+ 141.667 µM 2.11258703503147 0.0190387400019419 no 136 0.0173180646827217 184 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1719 st032227 49.2 µM 2.10412906960573 0.0194209568646084 no 137 0.0176835948554452 194 3125804
SGTC_2193 5925765 200 µM 2.10186358683763 0.019524434505888 no 138 0.0177826135412982 139 877370
SGTC_2041 5107442 45.335 µM 2.07936399084316 0.0205777819426921 no 139 0.0187919537991331 232 793005
SGTC_146 3448-8650 53.125 µM 2.07386353137253 0.0208424948056724 no 140 0.01904599340763 385 2891488 YIL048W NEO1
SGTC_2296 7971656 126.45 µM 2.07348619453843 0.0208607595543074 no 141 0.0190635273052718 236 666570
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 2.07076645134988 0.0209928081955234 no 142 0.0191903134125161 167 229346 A bile salt which induces apoptosis.
SGTC_2916 7875993 68.79 µM 2.05788458209268 0.0216278960996386 no 143 0.0198006070506071 217 1299250
SGTC_1249 0481-0015 10.2 µM 2.05684806533859 0.0216796956552994 no 144 0.0198504214761874 191 4227577
SGTC_1262 0737-0114 49.6 µM 2.05498317450991 0.0217731568638128 no 145 0.0199403149378411 235 765919
SGTC_2018 5133068 143 µM 2.0523063964981 0.021907901434555 no 146 0.0200699473816584 218 785362
SGTC_2641 levomentholum 100 µM 2.05088971268898 0.0219794994509986 no 147 0.0201388440981042 122 16666
SGTC_762 1165-0429 115 µM 2.03549917427066 0.0227701358858565 no 148 0.0209003357751841 214 5967793
SGTC_159 3970-0959 50 µM 2.00446635826462 0.0244373651355069 no 149 0.0225100635762984 423 6615653
SGTC_2513 baicalein 25.65 µM 1.98093503437148 0.0257688643530512 no 150 0.0237992797794939 214 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1465 k213-0056 144 µM 1.97677002347618 0.0260107509751992 no 151 0.0240338157759907 233 24048857 YMR208W ERG12
SGTC_2555 cholic acid 100 µM 1.97308434479932 0.0262263811508324 no 152 0.0242429767942383 201 6708657 Influences liver metabolism.
SGTC_1916 st067606 49.2 µM 1.96846077884733 0.0264989937603272 no 153 0.0245075223123895 283 19590279
SGTC_559 1550-0661 158 µM 1.96213049153299 0.0268760738359233 no 154 0.0248736469014139 208 5830875
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.95689469347089 0.0271913331327574 no 155 0.0251799252944038 310 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_438 sphingosine 6.67 µM 1.95652624134502 0.0272136341882191 no 156 0.0252015971478654 191 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1495 4469-0029 237 µM 1.95481676813063 0.0273173020503249 no 157 0.025302350637197 373 793680
SGTC_2139 5578692 56.4705 µM 1.94239091693979 0.0280807852516191 no 158 0.0260448970284485 200 650991 YMR113W FOL3
SGTC_1232 0279-0259 161 µM 1.94022661094155 0.0282155671817502 no 159 0.0261760779148077 240 1560000
SGTC_2353 9059630 146.67 µM 1.93858793383084 0.0283179734782709 no 160 0.0262757669853141 187 4779114
SGTC_1998 st075797 76.8 µM 1.933167146933 0.0286589426685436 no 161 0.0266078052353465 251 24208315
SGTC_2405 ticlatone 3.52 µM 1.92428192790489 0.0292252067761011 no 162 0.0271596272930734 305 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_3281 9140613 49.47 µM 1.91755564987056 0.029660033595231 no 163 0.027583689122852 208 16013766
SGTC_2127 5253358 187.912 µM 1.91419177587923 0.0298795003683821 no 164 0.027797828103497 236 20612
SGTC_375 3970-0961 9.27 µM 1.91321005329866 0.0299438035118548 no 165 0.0278605835105445 252 2898222
SGTC_1016 4226-1401 38 µM 1.91103517136026 0.0300866678051322 no 166 0.028000030595344 257 2901613
SGTC_1466 k213-0079 57.5 µM 1.89860040961801 0.0309143778857973 no 167 0.0288085172626958 246 3657981
SGTC_1568 digitonin 820 nM 1.8976619549083 0.0309776028766493 no 168 0.0288703136661642 279 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1742 st038235 28.8875 µM 1.89565896254906 0.0311129052005757 no 169 0.0290025775403647 330 564103 YBR002C RER2
SGTC_2378 9074213 121.43 µM 1.89389902387353 0.0312321923981801 no 170 0.0291192070502627 272 657714
SGTC_2187 6125751 200 µM 1.88688267075988 0.0317115211118342 no 171 0.0295880542102679 246 874498
SGTC_944 3370-0224 231 µM 1.87741245709287 0.0323681108373075 no 172 0.0302307927332628 264 4580514
SGTC_188 3229-0966 278.469 µM 1.8716297269536 0.0327745274210157 no 173 0.0306289238936657 307 5722370
SGTC_1025 k007-0731 70 µM 1.85393572858461 0.0340442845834297 no 174 0.0318741777973159 252 6256118
SGTC_2000 st075254 36.4 µM 1.85096360720738 0.0342614872918493 no 175 0.0320873944336809 207 17234175
SGTC_581 0958-0271 211 µM 1.85043004804269 0.0343006001455289 no 176 0.0321257957633349 352 4591145
SGTC_1264 0783-0040 158 µM 1.83499070296078 0.0354483787224054 no 177 0.0332535334993642 261 2855798
SGTC_580 1123-0028 41 µM 1.83380721178259 0.0355376451983559 no 178 0.0333413084195148 348 1677248 YPR107C YTH1
SGTC_2463 5473429 200 µM 1.82000221604042 0.0365925817562153 no 179 0.0343793337096584 244 5399405
SGTC_1104 tacrolimus 29.8 µM 1.81189666304438 0.0372238303404894 no 180 0.0350010825602363 297 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1414 3917-0015 5.4 µM 1.81116041648099 0.037281606280201 no 181 0.0350580117812921 229 6618702
SGTC_1121 fusaric acid 630.51 nM 1.81000968175189 0.0373720553332027 no 182 0.0351471428879844 304 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2760 etidronate 98.04 µM 1.80708267559144 0.03760292934683 no 183 0.0353746947161636 305 3305 A chelator and antioxidant.
SGTC_301 4119-0100 24.5 µM 1.8059179900235 0.0376951197497031 no 184 0.0354655752927392 345 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2154 5570129 200 µM 1.80167765764327 0.0380323220720571 no 185 0.0357980676244492 301 673366
SGTC_2539 epi(13)torulosol 80 µM 1.80114284768148 0.0380750257705281 no 186 0.0358401838687456 289 6708597
SGTC_1093 fluphenazine 7.97 µM 1.79991171004678 0.0381734787507489 no 187 0.0359372901726124 325 6602611 An atypical antipsychotic.
SGTC_1463 k081-0032 34.1 µM 1.79658255083639 0.0384407487936688 no 188 0.0362009582920528 197 977755
SGTC_2975 9084847 53.72 µM 1.79307125721407 0.0387242916050982 no 189 0.0364807654382241 303 27211724
SGTC_78 0336-0123 156.75 µM 1.77920511736104 0.0398606985877665 no 190 0.0376030698566099 255 6765896
SGTC_571 k831-0106 44.2 µM 1.77790351011181 0.0399687500523617 no 191 0.0377098518190673 259 4783639
SGTC_504 lovastatin 124 µM 1.77314281763941 0.0403659826915206 no 192 0.0381025222495545 241 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2073 5212005 126 µM 1.76449852925532 0.0410954552457635 no 193 0.0388240413755561 200 691789
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.76055057260501 0.0414321523352886 no 194 0.0391572503549298 252 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2035 5154463 94.595 µM 1.75548796384764 0.0418671789182385 no 195 0.0395879388242741 329 2769623
SGTC_1833 st055984 71 µM 1.74992514949089 0.042349444765651 no 196 0.0400656151880233 278 676288
SGTC_2832 7992762 51.95 µM 1.74534234650109 0.0427501164120928 no 197 0.0404626474342989 280 2985177
SGTC_631 k072-0230 41.5 µM 1.73900974739937 0.0433088083126675 no 198 0.0410165241956404 326 5773147
SGTC_3041 9091929 49.47 µM 1.7350653014813 0.0436597758366995 no 199 0.0413646196950196 330 25236887
SGTC_731 3966-0296 387 µM 1.7337444557335 0.0437778132416649 no 200 0.0414817174384238 305 660956
SGTC_176 1486-1328 72.834 µM 1.72103600438052 0.0449267065195702 no 201 0.0426221453424809 373 22310231
SGTC_1163 k060-0048 49.9 µM 1.72011702158557 0.0450107184588933 no 202 0.0427055861232548 357 6809982
SGTC_444 curcumin 90.4 µM 1.71669034311481 0.0453250952992886 no 203 0.0430178827645894 330 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1071 trifluoperazine 6.31 µM 1.71355932882104 0.0456138887281876 no 204 0.0433048442314621 345 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2384 9036245 200 µM 1.71280987036984 0.0456832350391198 no 205 0.0433737618361838 326 6462766
SGTC_1302 1159-0335 255 µM 1.70261030577687 0.0466354363815465 no 206 0.0443205100801789 302 649284
SGTC_3231 9132313 49.47 µM 1.7011025714789 0.0467775355268474 no 207 0.044461864070756 304 4905967
SGTC_1897 st060201 15 µM 1.69993565606445 0.0468877518487585 no 208 0.0445715145772943 284 611878
SGTC_2676 harmalol 100 µM 1.69761769604161 0.047107303220555 no 209 0.0447899703473743 328 5459187 A monoamine oxidase inhibitor
SGTC_2594 a-mangostin 100 µM 1.69706420654012 0.0471598500724483 no 210 0.0448422611826929 365 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1845 st056753 3.01 µM 1.69618163886678 0.047243735935416 no 211 0.0449257432901038 357 5375839
SGTC_3253 9135987 49.47 µM 1.69129320826028 0.0477105370880861 no 212 0.0453904082776758 268 4182430
SGTC_1207 2099-0101 141 µM 1.6843584238092 0.0483790751355841 no 213 0.0460562103446518 364 5837381
SGTC_1134 3477-0009 42.5 µM 1.68001389987437 0.0488017060837733 no 214 0.0464773056681859 385 3973534
SGTC_1021 4476-0760 85.3 µM 1.67993284739462 0.0488096187359083 no 215 0.0464851909900732 347 746768
SGTC_3190 9110366 49.47 µM 1.67528191744083 0.0492653802606364 no 216 0.0469394657921995 262 17123768
SGTC_1552 6-methylflavone 10.6 µM 1.67476118280957 0.0493166197848207 no 217 0.0469905488788703 270 689013
SGTC_2452 5863136 48.41 µM 1.67154589964888 0.0496339420651044 no 218 0.0473069502480659 336 2184096
SGTC_2443 5493264 126.67 µM 1.66945326377433 0.0498413419945045 no 219 0.0475137926379216 329 5340055
SGTC_221 trifluoperazine 10.304 µM 1.66535794184479 0.0502492268206113 no 220 0.0479206825234006 545 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1433 4060-0023 7.6 µM 1.66261021374332 0.0505243825955739 no 221 0.0481952426347801 339 3840627
SGTC_2254 7938975 95.19 µM 1.66033313157513 0.0507533165600443 no 222 0.0484237270353561 418 2969277
SGTC_194 1486-1323 56.904 µM 1.65650064722141 0.0511404923808497 no 223 0.048810237049185 335 5178754
SGTC_818 4072-2707 53.5 µM 1.65500443079023 0.0512922837124684 no 224 0.0489617995695274 304 882871
SGTC_1600 coumarin 106 71.1 µM 1.65368226410286 0.0514267157793157 no 225 0.0490960440659306 355 100336 A hepatotoxic, DNA x-linker.
SGTC_214 4373-3496 70 µM 1.65275917828631 0.0515207370705869 no 226 0.0491899425608649 497 3779166
SGTC_3283 9109332 35.8195 µM 1.64130732061336 0.0526985725967128 no 227 0.0503668186222078 270 17027281
SGTC_2669 eugenol 100 µM 1.64080895321189 0.0527503113701535 no 228 0.0504185395834345 266 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_31 0508-1974 57.237 µM 1.63637939454532 0.0532119456911655 no 229 0.0508801044708999 336 6810525
SGTC_1253 0550-0034 176 µM 1.63548147095917 0.0533059136500416 no 230 0.0509740779216936 340 5969915
SGTC_1633 st005664 67.9 µM 1.63222359802945 0.0536479557136303 no 231 0.0513161956589233 381 2063822
SGTC_3180 9109287 49.47 µM 1.63113859509991 0.0537622546268093 no 232 0.0514305392547519 313 18891271
SGTC_379 3970-0972 5.9 µM 1.63087267692848 0.0537902970042891 no 233 0.0514585940736681 357 2898042 YBL034C STU1
SGTC_2771 fluoxetine 41.05 µM 1.62709247131109 0.0541901922485763 no 234 0.0518587298863721 317 3386 A selective serotonin reuptake inhibitor.
SGTC_174 3553-0389 74.3 µM 1.62233255039018 0.0546970703452923 no 235 0.0523660813456996 310 738071
SGTC_3351 9150312 21.596 µM 1.62215971462267 0.0547155456983534 no 236 0.0523845774851964 377 4904905
SGTC_2422 chlorphenesin carbamate 384.24 µM 1.62180286428655 0.0547537069760367 no 237 0.0524227824811476 436 2724 A muscle relaxant with antifungal properties.
SGTC_1700 st030840 7.9285 µM 1.62013340254593 0.0549325173669415 no 238 0.0526018117585684 364 5499307
SGTC_732 3970-1727 52.7 µM 1.6199842784148 0.0549485119729795 no 239 0.0526178270695159 323 1275699
SGTC_639 0833-0042 114 µM 1.61893162278079 0.055061521356109 no 240 0.0527309879967325 393 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2585 alliin 100 µM 1.6186390760645 0.0550929607226852 no 241 0.0527624711578932 400 87310 A garlic compound which reacts with lipids.
SGTC_1257 0669-0121 16 µM 1.61790702219409 0.0551716951272331 no 242 0.0528413183558879 416 4307855
SGTC_1935 st074532 41.6 µM 1.61454145474487 0.0555348154049287 no 243 0.0532050162980048 441 2829742
SGTC_1417 3966-0327 90.4 µM 1.6091112775846 0.0561246667852928 no 244 0.0537960058574681 397 651118
SGTC_521 r062-0005 13.8 µM 1.60730126764225 0.0563223727255941 no 245 0.0539941481839243 354 2832033
SGTC_41 0478-0632 82.643 µM 1.60528715000434 0.0565430180997849 no 246 0.0542153128839401 431 3750424
SGTC_1180 1193-0155 285 µM 1.60385668480416 0.0567001379377133 no 247 0.0543728232176792 366 2921347
SGTC_1359 1582-0056 520 nM 1.5932894078689 0.0578715078965621 no 248 0.0555476408820649 415 3661189
SGTC_1944 st076371 56.9 µM 1.58946962969835 0.058299576651914 no 249 0.0559772026915686 377 24208455
SGTC_212 3807-4682 38.772 µM 1.58592755468026 0.0586987430278317 no 250 0.056377872172232 514 3125501 YBL034C STU1
SGTC_2742 clothiapine 36.27 µM 1.58389995193969 0.0589282028971748 no 251 0.0566082441693854 300 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_665 3914-0008 307 µM 1.57738912356586 0.059669781412778 no 252 0.0573530082586777 387 1069549
SGTC_972 1319-0219 195 µM 1.5762976214047 0.0597948153304984 no 253 0.0574786147814872 384 23903702
SGTC_3093 9117344 49.47 µM 1.57594066721756 0.0598357497068545 no 254 0.0575197388328785 370 24824913
SGTC_2455 5377712 9.75 µM 1.57479102059162 0.0599677367563284 no 255 0.0576523448785056 342 2243908
SGTC_1283 0922-0125 16.4 µM 1.57464396658953 0.0599846359651503 no 256 0.0576693241581516 411 3360884
SGTC_2679 rapamycin 1 nM 1.57190275875575 0.060300334350486 no 257 0.0579865523329664 521 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_864 0469-0573 172 µM 1.5684110957515 0.0607043423561663 no 258 0.058392611642007 364 689425
SGTC_1698 5-fluorocytosine 1.055 µM 1.56830808653004 0.0607162932610857 no 259 0.0584046248183603 344 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2199 6590217 200 µM 1.5680859570494 0.0607420705007141 no 260 0.0584305366835237 306 703109
SGTC_1325 1431-0015 227 µM 1.56730211170518 0.0608331010188688 no 261 0.0585220460147097 345 1103340
SGTC_1524 corynanthine 62.1 µM 1.56234938461275 0.061410745982628 no 262 0.0591028519995912 375 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1410 3909-8106 77.9 µM 1.55907704333541 0.0617947493691983 no 263 0.0594890731886278 340 1039210
SGTC_1461 k072-0203 53.8 µM 1.55501490851808 0.0622740382071571 no 264 0.0599712593623555 371 5418714
SGTC_1666 st014829 29 µM 1.55482329493592 0.0622967179865332 no 265 0.0599940797769803 422 3858230
SGTC_3255 9139072 49.47 µM 1.55364504915169 0.0624363192146254 no 266 0.0601345536628377 377 17646060
SGTC_3205 9113483 49.47 µM 1.55093321691821 0.0627585499552625 no 267 0.0604588445486681 429 17018033
SGTC_1713 st033146 12.748 µM 1.54534547234666 0.0634265930141042 no 268 0.0611313610024984 403 674619
SGTC_1340 1486-1359 257 µM 1.54224922969166 0.0637991404070847 no 269 0.0615065205882401 380 4309068
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.53960677249921 0.0641184314981514 no 270 0.061828116823956 385 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2750 bromebric acid 70.15 µM 1.53413884316666 0.0647830710702456 no 271 0.0624977495712277 471 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_988 1497-1057 103 µM 1.53308486920848 0.0649117968688188 no 272 0.0626274726334863 417 3533044
SGTC_745 0469-0705 296 µM 1.53245550905441 0.0649887576215742 no 273 0.0627050342705762 453 3486736
SGTC_569 4130-2812 160 µM 1.53067765568028 0.0652065435030212 no 274 0.0629245393760572 296 743552
SGTC_143 4032-1194 15.74 µM 1.52484862578004 0.0659245693294369 no 275 0.0636484291363283 501 1806963
SGTC_1183 1254-0324 198 µM 1.51980997381503 0.0665501595277649 no 276 0.0642793708393244 402 5799357
SGTC_582 0987-0078 156 µM 1.51187943714683 0.0675440967057544 no 277 0.0652822680192391 576 1625765
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.50866828557649 0.0679497990950178 no 278 0.0656917870377342 418 5282309
SGTC_2011 4012611 177 µM 1.50635575762542 0.0682431314488444 no 279 0.0659879358461079 437 2049887
SGTC_1832 st054113 55 µM 1.50557733723236 0.0683420896414078 no 280 0.0660878549209744 382 1251267
SGTC_2292 7671323 168.05 µM 1.49647596129032 0.0695073506858066 no 281 0.0672648338141015 441 937504
SGTC_2748 diazoxide 86.69 µM 1.49631148311583 0.0695285489138418 no 282 0.0672862520406153 351 3019 A potassium channel activatior.
SGTC_1135 dihydrocapsaicin 536.708 nM 1.49594683741966 0.069575562826117 no 283 0.0673337547347601 447 107982 A Capsaicinoid.
SGTC_2902 5787006 60.46 µM 1.48724342408732 0.0707049761125408 no 284 0.0684752654813815 423 591003
SGTC_1252 0493-0875 34.8 µM 1.48386359330767 0.0711473441115242 no 285 0.0689225560162638 427 3960963
SGTC_481 bay k-8644 50 µM 1.48170731768027 0.071430675971955 no 286 0.0692090945746602 413 2303 A calcium channel antagonist.
SGTC_1431 4049-0260 9.09 µM 1.47708336576901 0.0720411759880713 no 287 0.0698266459399015 432 3854841
SGTC_702 1488-0190 94 µM 1.47503471467676 0.0723129346413518 no 288 0.0701016053204298 399 949357
SGTC_926 2268-1401 59.4 µM 1.47292585909734 0.0725934993856326 no 289 0.0703855142286264 455 2931578
SGTC_1744 st037937 38.9 µM 1.46670756220011 0.0734256435089217 no 290 0.0712278124151736 440 1016152
SGTC_1307 1187-1599 12.2 µM 1.46047386387617 0.0742671515500933 no 291 0.0720799427544035 430 1538471
SGTC_1961 st076550 68.7 µM 1.45630793741952 0.0748336166443386 no 292 0.0726537561453453 397 1579337
SGTC_423 5-fluorouracil 457 µM 1.45583335635816 0.0748983567596697 no 293 0.0727193461326483 459 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_432 NS 1619 61.3 µM 1.45427365818112 0.0751114244050875 no 294 0.0729352252978515 411 4552 A K+/calcium channel activator.
SGTC_672 1441-0018 53.7 µM 1.45224549299711 0.0753891794147948 no 295 0.0732166786644426 418 251141
SGTC_1773 st048542 73.5835 µM 1.44357931740161 0.0765848279578516 no 296 0.0744286731248236 474 3237138
SGTC_891 0929-0073 133 µM 1.44042483127832 0.0770236061275907 no 297 0.0748736212967923 437 5603632
SGTC_1082 camptothecin 424.86 nM 1.43727059766198 0.077464256933668 no 298 0.0753205599626736 417 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_698 k064-0052 127 µM 1.4336065440177 0.0779785309635847 no 299 0.0758422874941618 382 5088751
SGTC_286 k060-0067 22.9 µM 1.43061668574271 0.0784000932722932 no 300 0.0762700513416472 440 5985051
SGTC_3198 9112019 49.47 µM 1.4296745519402 0.0785332891115333 no 301 0.0764052236827828 443 45595555
SGTC_519 k048-0011 62.8 µM 1.42480489521014 0.079224481446682 no 302 0.0771068034510689 457 6836379
SGTC_2883 9059145 45.46 µM 1.42337140132585 0.0794288245064041 no 303 0.0773142591975243 419 16476510
SGTC_1224 0823-0416 294 µM 1.42170470686773 0.0796669112991819 no 304 0.077555996571431 463 3598164
SGTC_2078 5212016 200 µM 1.42142910800502 0.0797063324781648 no 305 0.0775960246689861 402 1899708
SGTC_1059 3448-6867 171 µM 1.42097630729668 0.0797711323348445 no 306 0.0776618236925419 453 3934407
SGTC_789 1309-1135 70.6 µM 1.42021788474155 0.079879758684821 no 307 0.0777721292298775 492 3092424
SGTC_973 1325-0077 65.9 µM 1.41917229479275 0.0800296984373071 no 308 0.0779243955339736 497 2835149
SGTC_616 4092-0450 108 µM 1.41438702358729 0.0807186326216305 no 309 0.078624149017783 500 787165
SGTC_2656 pseudo-anisatin 100 µM 1.41312043369952 0.0809017306478912 no 310 0.0788101580385371 414 6708809 A neurotoxin.
SGTC_1752 st044819 83.042 µM 1.41282121067141 0.0809450320293903 no 311 0.0788541500212874 474 441209 YML126C ERG13
SGTC_1866 st057638 64 µM 1.4082335824928 0.0816111123164107 no 312 0.0795309575953051 448 688802
SGTC_1078 idebenone 36.1 µM 1.40661987637112 0.0818463870732716 no 313 0.0797700679846414 537 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2882 9058044 58.44 µM 1.40575006111943 0.0819734160454772 no 314 0.0798991779194371 438 18076804
SGTC_2869 9037858 32.47 µM 1.40451237354691 0.0821544255886618 no 315 0.0800831648483806 413 27187042
SGTC_767 0929-0023 86 µM 1.40421660860118 0.0821977252077948 no 316 0.0801271788012817 578 1204563
SGTC_1624 st003710 6.25 µM 1.39850629713284 0.0830370808031226 no 317 0.0809805415031986 546 24207033
SGTC_2009 4012297 12.05 µM 1.39701413301207 0.0832574719122253 no 318 0.0812046605839479 472 45595307
SGTC_759 3486-0358 89.3 µM 1.39377791955006 0.0837369680769497 no 319 0.0816923389418056 536 875103
SGTC_3191 9110352 49.47 µM 1.38698342129151 0.0847504255134567 no 320 0.0827234091114414 444 17122424
SGTC_2709 st078560 56 µM 1.38295137782246 0.0853561722973339 no 321 0.0833398875391981 475 17250903
SGTC_3234 9132280 49.47 µM 1.38243261337943 0.0854343428269575 no 322 0.0834194540123695 513 17612295
SGTC_2281 7943571 200 µM 1.38221176260479 0.0854676382108809 no 323 0.0834533447380607 511 1244024
SGTC_412 gemfibrozil 100 µM 1.38143617475508 0.0855846425503957 no 324 0.0835724448012556 413 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2772 vinpocetine 57.06 µM 1.38003760541491 0.0857959322775868 no 325 0.0837875332760329 479 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_380 3970-0968 6 µM 1.37782792956371 0.0861305558357545 no 326 0.0841282103296341 472 2891601
SGTC_727 3032-0951 202 µM 1.37774066675427 0.0861437905417348 no 327 0.0841416853960333 453 3652836
SGTC_1106 tegaserod maleate 11.7 µM 1.37241857896116 0.0869538431888408 no 328 0.0849665848304468 524 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_3318 9139014 38.6185 µM 1.36729208086936 0.0877394934028045 no 329 0.0857668864539902 462 16643984
SGTC_620 0109-0052 432 µM 1.3664946078944 0.0878621828296911 no 330 0.0858918860779835 498 493037
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.36528984481057 0.0880477755301348 no 331 0.0860809847490196 537 688667
SGTC_2174 5790901 200 µM 1.36476867088981 0.0881281524293476 no 332 0.0861628842457779 484 786020
SGTC_2821 7996764 71.43 µM 1.36437711156363 0.0881885757801405 no 333 0.0862244538877616 524 2987135
SGTC_141 0443-0274 32.331 µM 1.36295047845084 0.0884089874433715 no 334 0.0864490591670552 621 1627241
SGTC_91 0417-1751 58.384 µM 1.36243722319717 0.0884883845663452 no 335 0.0865299716006036 615 6795624
SGTC_1060 3448-7350 82 µM 1.36201845033016 0.0885532052467932 no 336 0.0865960312308597 543 570178
SGTC_84 0443-0269 128.823 µM 1.35865983033341 0.0890743566047794 no 337 0.0871272033081989 511 6150058
SGTC_1838 st055369 84.5 µM 1.3586082269561 0.0890823815808243 no 338 0.0871353834163909 453 676036
SGTC_3259 9138485 49.47 µM 1.34951971615708 0.0905041671009556 no 339 0.088585045932957 555 17646153
SGTC_884 0851-0618 334 µM 1.34664937079716 0.0909566793843625 no 340 0.0890465927135348 547 9642473
SGTC_264 promethazine 12.5 mM 1.34651657084924 0.0909776559544789 no 341 0.0890679899647025 629 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1413 3910-0535 34.4 µM 1.34477954038907 0.0912523611537293 no 342 0.0893482196372652 509 2876951
SGTC_839 0122-0028 230 µM 1.34347154993233 0.0914596207651207 no 343 0.0895596661390066 594 759448
SGTC_3275 9138069 49.47 µM 1.34269876207873 0.0915822378924511 no 344 0.0896847678612166 474 17617007
SGTC_1871 st057448 67.3 µM 1.33739002797095 0.0924278614373707 no 345 0.0905476788972498 534 691747
SGTC_643 k048-0106 28.4 µM 1.33712008488034 0.0924710142795581 no 346 0.090591721045381 527 6763920
SGTC_2189 6047310 154.431 µM 1.33507212546478 0.0927988847341696 no 347 0.0909263707651701 489 711535
SGTC_3242 9133940 49.47 µM 1.33401825943302 0.0929679392785574 no 348 0.0910989362322919 506 17248444
SGTC_1446 4239-0190 62 µM 1.33270389100539 0.0931791008757087 no 349 0.0913144979346492 569 1340085
SGTC_2717 st081029 62.2815 µM 1.33091521119447 0.0934670326619986 no 350 0.0916084557643487 489 5292846
SGTC_3076 9116187 49.47 µM 1.33010270184094 0.0935980427709914 no 351 0.0917422177337309 476 27241210
SGTC_911 3456-4043 236 µM 1.32935013261758 0.0937195089716398 no 352 0.0918662408904809 544 914281
SGTC_790 1575-0012 79.1 µM 1.32677908709157 0.0941353588645415 no 353 0.0922908851524681 540 378741 YLR208W SEC13
SGTC_981 1488-1094 54.9 µM 1.32629424059339 0.0942139319590413 no 354 0.0923711269107509 461 3449522
SGTC_3029 9088683 49.47 µM 1.32560195732803 0.094326205609455 no 355 0.0924857887784345 515 25236615
SGTC_2783 7738165 71.43 µM 1.32180849675981 0.0949431765698946 no 356 0.0931159641283878 430 17201110
SGTC_2622 2-methoxyxanthone 59.94 µM 1.32075000684267 0.095115859421716 no 357 0.0932923670376604 547 71034 A hepatoprotective.
SGTC_1423 4048-0112 5.59 µM 1.31802816517905 0.0955609647041304 no 358 0.0937471098118818 528 X1423
SGTC_1169 aniline yellow 25.8 µM 1.31582383164172 0.0959225633116212 no 359 0.0941165892401637 495 6051 A DNA damaging agent.
SGTC_3354 9151612 71.43 µM 1.30961440351646 0.0969465653258131 no 360 0.0951631566655414 578 27261949
SGTC_2347 9049783 174.81 µM 1.30799512204944 0.097214916923884 no 361 0.0954374818979572 588 6467988 YPL169C MEX67
SGTC_541 4513-1321 94 µM 1.30649520345037 0.0974639733063161 no 362 0.0956921045603241 537 747515
SGTC_3030 9087619 49.47 µM 1.30330519354925 0.0979952190999371 no 363 0.0962352943613398 523 25236973
SGTC_1853 st056710 91.2 µM 1.30244467228615 0.0981388880680381 no 364 0.0963822099607785 564 269167
SGTC_2191 5911152 200 µM 1.30146897529291 0.0983019728897533 no 365 0.0965489886616789 525 2875902
SGTC_3 0833-0587 95.581 µM 1.30056297389089 0.0984535859499897 no 366 0.0967040438428214 536 5382644
SGTC_2800 7887935 81.82 µM 1.29855061303378 0.0987909529608893 no 367 0.09704909804791 533 2961002
SGTC_3055 9094636 49.47 µM 1.29543033240557 0.0993157313924943 no 368 0.097585909984552 515 25236176
SGTC_2117 5521686 200 µM 1.29442977683432 0.0994844386995224 no 369 0.0977585054088415 541 803312
SGTC_744 1594-0068 283 µM 1.29398971731169 0.0995587050177919 no 370 0.0978344863119632 605 668392
SGTC_1354 1498-1681 81 µM 1.28875048279493 0.100446015022895 no 371 0.0987424229050777 595 5754243
SGTC_1615 st002656 86.5 µM 1.28265753364937 0.101485149831461 no 372 0.0998060419681748 551 1584458
SGTC_2146 5545642 200 µM 1.28140268678722 0.101700129185675 no 373 0.100026130466196 563 825326
SGTC_1993 st073995 70.8 µM 1.28029395228757 0.101890352420581 no 374 0.100220886924121 567 3098394
SGTC_2196 6573537 42.6665 µM 1.27982041268217 0.101971675481557 no 375 0.100304151552577 527 2903087
SGTC_3315 9136395 68.55 µM 1.27688520361146 0.102476805934289 no 376 0.100821389340519 594 16876844
SGTC_1706 st031321 9.9705 µM 1.27518907253929 0.102769527222192 no 377 0.101121164057667 559 6103185
SGTC_1140 3229-1848 2.98 µM 1.2749995136698 0.102802279336667 no 378 0.101154707063535 564 2849525
SGTC_177 1327-0068 8.361 µM 1.27366020945448 0.103033901388578 no 379 0.10139193198604 585 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_603 3794-0023 45.9 µM 1.27284293468312 0.103175428688596 no 380 0.1015368911474 543 3802260
SGTC_1847 st056231 15 µM 1.27163585963457 0.103384715766 no 381 0.101751264762866 628 5393180
SGTC_735 3076-0345 636 µM 1.27033864753669 0.103609974500913 no 382 0.101982013617822 627 2888990
SGTC_828 2074-0507 139 µM 1.26994870698017 0.103677756600944 no 383 0.102051450856124 601 X828
SGTC_2711 st079103 59.1 µM 1.26994436398188 0.103678511711345 no 384 0.102052224413314 531 54693780
SGTC_749 1000-0129 128 µM 1.26915437118257 0.103815932923245 no 385 0.102193005698188 609 708470
SGTC_1080 nisoldipine 24.4 µM 1.26484023967454 0.10456871807329 no 386 0.102964301654857 605 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2161 5662504 8.5105 µM 1.2597845432603 0.105455923751135 no 387 0.103873548579307 557 2859334
SGTC_761 k216-0224 480 µM 1.25973615810371 0.105464440907 no 388 0.103882278501707 620 1340404
SGTC_402 epigallocatechin gallate 10 µM 1.25852291202291 0.105678169198691 no 389 0.104101353179815 603 65064 An antioxidant.
SGTC_688 0527-0193 473 µM 1.25521214854159 0.106262993932242 no 390 0.10470087827753 543 4007154
SGTC_1565 sinapyl alcohol 95.1 µM 1.25141050347541 0.106937408576075 no 391 0.105392373564039 549 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2495 cafestol 54.53 µM 1.25115857679612 0.106982209398922 no 392 0.105438313879226 539 16667697 An anti-infammatory.
SGTC_2138 5575593 77.673 µM 1.25108766503013 0.106994822277169 no 393 0.105451247669745 534 762213
SGTC_1297 1068-0111 14.1 µM 1.25034957719226 0.107126167593746 no 394 0.105585937661989 554 767057
SGTC_170 4197-0004 226 µM 1.24892130577747 0.107380663627823 no 395 0.105846929030893 520 218692
SGTC_2845 9003024 42.97 µM 1.24389989890691 0.10827886018595 no 396 0.106768203293758 596 2990173
SGTC_795 0685-0265 78 µM 1.23883356047434 0.109190560956953 no 397 0.107703571260895 594 302754
SGTC_2129 girgensonine 121.053 µM 1.23536630782483 0.109817673045409 no 398 0.108347103049037 652 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_65 0798-0905 34.986 µM 1.23353622913084 0.110149714563107 no 399 0.108687884314044 702 3602145
SGTC_195 4234-0266 16.654 µM 1.22820534498235 0.111121029578426 no 400 0.10968494637364 639 2303354
SGTC_1665 st014639 11.4 µM 1.22110178358409 0.112424845958938 no 401 0.111023742242972 652 981133 YIL048W NEO1
SGTC_2856 9022925 19.48 µM 1.21521124312129 0.113514280036659 no 402 0.112142766687134 629 4944862
SGTC_1412 3909-8563 178 µM 1.2119707848475 0.114116790697234 no 403 0.112761782080415 678 23767530
SGTC_1306 1185-0270 9.02 µM 1.21127023036864 0.114247346357875 no 404 0.112895927104402 668 1548076
SGTC_2250 alverine citrate 130 µM 1.20959419216362 0.114560125175441 no 405 0.113217323914536 719 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1806 st050005 60.3 µM 1.2092347742772 0.114627278291897 no 406 0.113286330746505 604 5194765
SGTC_2732 terfenadine 20 µM 1.20826047944329 0.114809455004291 no 407 0.113473542441315 551 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1381 2324-0066 62.1 µM 1.20511153938226 0.115399662125054 no 408 0.11408012283872 595 10885928
SGTC_848 0368-0089 85.6 µM 1.20497152407625 0.115425955228751 no 409 0.114107147522591 641 762535
SGTC_1014 4130-3005 69.3 µM 1.20325397142873 0.115748836353801 no 410 0.114439027518227 642 743608
SGTC_533 1222-0222 6.71 µM 1.20134372011289 0.116108695596717 no 411 0.114808948850896 666 3982874
SGTC_847 0342-0274 5.54 µM 1.19987780541362 0.116385387281569 no 412 0.115093400446099 629 18097
SGTC_1395 3486-0190 4.35 µM 1.19798452644372 0.116743435816408 no 413 0.115461520482688 662 6748079
SGTC_422 cantharidin 155 µM 1.19709922654762 0.116911127500604 no 414 0.115633940706914 617 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_321 4534-3890 65.3 µM 1.19655267129043 0.117014740067227 no 415 0.115740478598322 618 699746
SGTC_697 0508-1955 564 µM 1.19407123616639 0.117485973525955 no 416 0.116225051842305 682 6243113
SGTC_2720 fluspirilene 36.88 µM 1.19378934051848 0.11753959139351 no 417 0.116280191194715 559 3396 An atypical antipsychotic.
SGTC_285 1486-1325 46 µM 1.19367610725299 0.117561133765174 no 418 0.116302345072408 655 22310230
SGTC_2923 7992654 58.14 µM 1.19196683095587 0.11788665928911 no 419 0.116637125652206 619 2985126
SGTC_1424 4048-1941 275 µM 1.18962598963738 0.118333498077054 no 420 0.117096713083428 688 X1424
SGTC_783 0848-0141 92.7 µM 1.18816571672288 0.118612852550534 no 421 0.11738406379281 603 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2931 9014674 55.67 µM 1.1878630792168 0.118670806237198 no 422 0.117443678845446 597 2996810
SGTC_2203 7227154 166.4 µM 1.18646355516577 0.118939068807936 no 423 0.117719642900967 584 896304
SGTC_1126 isoteolin 1.0172 µM 1.18616788622962 0.118995797761191 no 424 0.117778002820398 622 133323
SGTC_3285 9112818 20.8695 µM 1.18489008186557 0.119241185266277 no 425 0.118030454674023 679 17017947 YPR165W RHO1
SGTC_96 0929-0093 37.281 µM 1.182767089527 0.119649670552987 no 426 0.118450733488471 591 6991579
SGTC_3151 9099821 49.47 µM 1.18171672653365 0.119852135595995 no 427 0.118659059582517 608 17174189
SGTC_2201 6605497 169.863 µM 1.17899064610754 0.120378733867109 no 428 0.119200950266654 613 670741
SGTC_1812 st052057 4.327 µM 1.17841341276818 0.120490447070249 no 429 0.119315916541235 659 3645418
SGTC_2125 5246583 200 µM 1.17818711838824 0.120534262220738 no 430 0.119361008432126 727 835267
SGTC_125 0133-0007 11.75 µM 1.17800325848605 0.120569869461595 no 431 0.119397653593508 682 26541
SGTC_1204 4049-0315 18.3 µM 1.17548561719601 0.121058193848717 no 432 0.119900244020812 627 588402
SGTC_633 0437-0093 97.7 µM 1.17501383365559 0.121149856065912 no 433 0.119994590673291 620 2831118
SGTC_751 0833-0568 350 µM 1.17156119982982 0.121822149883618 no 434 0.120686636724852 645 6954252
SGTC_150 3970-0969 77.2 µM 1.16940000108921 0.122244308036513 no 435 0.121121254705584 728 6615640
SGTC_102 gallobenzophenone 83.616 µM 1.16647020579392 0.122818238359593 no 436 0.1217121939605 654 70837
SGTC_1801 st050089 28.441 µM 1.16249944557353 0.123599099939734 no 437 0.122516324881266 753 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2951 9072950 58.06 µM 1.16204376326443 0.123688933084573 no 438 0.122608844406396 695 16488155
SGTC_531 3788-1495 174 µM 1.15962470473526 0.124166591435124 no 439 0.123100819059974 642 2896655
SGTC_1958 st076513 41.9 µM 1.15813291720119 0.12446179675713 no 440 0.123404899361575 647 732122 YGL099W LSG1
SGTC_2026 5148700 152 µM 1.15616095329172 0.124852775319701 no 441 0.123807663948757 647 79838
SGTC_2991 9074669 71.4286 µM 1.15590142781822 0.124904294908729 no 442 0.123860739281272 721 17333109
SGTC_224 benfluorex 43.875 µM 1.14333429953484 0.127416843380463 no 443 0.126449909655283 582 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_976 1348-1067 47.6 µM 1.14323706441242 0.127436419678169 no 444 0.126470088653667 734 5310671 YGL099W LSG1
SGTC_2505 galangin 7.89 µM 1.14161318707386 0.12776366325956 no 445 0.126807420078578 581 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2657 nystatin 74.44 µM 1.13699006709662 0.128698510482337 no 446 0.127771219023352 704 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2534 helenine 20.12 µM 1.13672766530459 0.128751713064698 no 447 0.127826075173837 609 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_894 0960-0238 55.9 µM 1.13529619006961 0.129042216703387 no 448 0.128125619008409 679 6741907 YDL195W SEC31
SGTC_1705 st027868 56.3335 µM 1.1316786284069 0.12977838941411 no 449 0.128884784864438 655 292948
SGTC_2235 salicylic acid 500 µM 1.1316642068087 0.129781330013277 no 450 0.128887817549318 669 338 A COX inhibitor and kinase inhibitor.
SGTC_900 1112-0045 141 µM 1.13048210421358 0.13002252052732 no 451 0.129136567513884 538 56211 YIL048W NEO1
SGTC_1416 3966-0321 25.3 µM 1.12846725727343 0.130434334903781 no 452 0.129561318676399 698 582530 YLR208W SEC13
SGTC_704 1310-0270 142 µM 1.12794602820348 0.130541015578769 no 453 0.1296713566999 699 5718033
SGTC_1949 st076024 69.1 µM 1.12744792125391 0.130643020183953 no 454 0.129776573822387 649 2921930
SGTC_1462 k081-0014 26.5 µM 1.12554359014273 0.131033505773739 no 455 0.130179378295891 522 3270634
SGTC_2252 omeprazole 400 µM 1.12195284296745 0.131771985125185 no 456 0.130941245423697 584 4594 A proton pump inhibitor.
SGTC_1671 st016596 74.5 µM 1.12152176103189 0.131860834872904 no 457 0.131032916999263 725 2829167
SGTC_613 3914-0030 117 µM 1.11949838645691 0.132278422202184 no 458 0.131463789436024 439 1145395
SGTC_1534 6-azauridine 81.6 µM 1.11728807380161 0.13273563090562 no 459 0.131935586557944 740 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_433 pimozide 108 µM 1.11451794697284 0.133310173790352 no 460 0.132528524750762 557 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_712 r015-0009 80.6 µM 1.11375258688702 0.133469215829735 no 461 0.132692671230723 624 6813872 YLR060W FRS1
SGTC_2171 5739187 198.077 µM 1.11226293040558 0.133779140936801 no 462 0.133012558668339 626 2262761
SGTC_1570 verbenone 133 µM 1.11094303476375 0.134054160114755 no 463 0.133296435042656 735 29025 A natural terpanoid with antifungal properties.
SGTC_1147 3809-1045 12.3 µM 1.1071778220575 0.134840829711816 no 464 0.134108527112348 681 325925
SGTC_61 0978-8327 98.565 µM 1.10684901116712 0.134909678554148 no 465 0.134179607033909 737 6150059 YHR072W ERG7
SGTC_2707 st078556 66.6 µM 1.10666991306413 0.134947189574958 no 466 0.134218334030019 694 17250899
SGTC_1328 1441-0025 69.2 µM 1.10614822369501 0.135056495043866 no 467 0.13433118445718 649 4562601
SGTC_1514 1189-1591 158 µM 1.10438436522068 0.135426512041268 no 468 0.13471322002283 735 767698 YMR146C TIF34
SGTC_2725 haloperidol 53.21 µM 1.10410053416241 0.13548611810839 no 469 0.1347747647985 699 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3207 9114163 49.47 µM 1.10379896262045 0.135549469468803 no 470 0.134840177484745 765 849233
SGTC_13 0199-0087 65 µM 1.10244350299811 0.135834462491584 no 471 0.135134453789104 719 4589825
SGTC_2807 7945238 51.95 µM 1.09696501329292 0.13699052495859 no 472 0.136328343286738 711 17148797
SGTC_2092 5303694 80.6725 µM 1.09630949305879 0.137129300862657 no 473 0.136471678209481 730 1963699
SGTC_3107 9121808 49.47 µM 1.08914416567605 0.138652488296792 no 474 0.138045158123502 662 662681
SGTC_2472 5377652 49.4 µM 1.08863172605254 0.138761861338272 no 475 0.1381581601651 741 1610903
SGTC_3130 9127414 49.47 µM 1.08825349529812 0.138842627064149 no 476 0.138241607213544 708 1494646
SGTC_3069 9117009 49.47 µM 1.08311389205621 0.139943288508815 no 477 0.139378936756571 579 41904981
SGTC_1470 k295-0292 231 µM 1.08125857080064 0.140342063807238 no 478 0.139791055333176 752 5045612
SGTC_2284 7945075 39.21 µM 1.0812455875944 0.140344857081579 no 479 0.139793942180836 813 1245402
SGTC_184 1494-0393 24.714 µM 1.08071376908185 0.140459307722315 no 480 0.139912228157749 732 3090647
SGTC_2194 5927483 104.545 µM 1.08037214545071 0.14053286066308 no 481 0.139988247253126 753 760979
SGTC_2192 5915882 198.485 µM 1.07752649308132 0.141146557003776 no 482 0.140622560764409 674 2876149
SGTC_2484 5809818 12.04 µM 1.07658473244115 0.14135005769202 no 483 0.140832914006135 696 2870548
SGTC_2034 5197015 53.07 µM 1.07578947449087 0.141522056089964 no 484 0.141010710331908 730 780676
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.07346695693663 0.142025181793914 no 485 0.14153082829065 642 61125 An anti-inflammatory.
SGTC_822 1487-0950 154 µM 1.07237447258865 0.142262264311031 no 486 0.141775934504937 731 1958375
SGTC_2109 5483026 200 µM 1.07168754198106 0.142411473737371 no 487 0.141930199135611 753 759335
SGTC_2431 5490079 200 µM 1.07148520898237 0.14245544302555 no 488 0.141975658899994 749 5722345
SGTC_190 3970-0790 3.722 µM 1.0708776476723 0.142587528266414 no 489 0.142112223769323 707 2832352
SGTC_928 2764-0428 58.7 µM 1.06876375837796 0.143047737909187 no 490 0.142588066842934 774 662578
SGTC_3042 9091578 49.47 µM 1.0661361203706 0.143621192147478 no 491 0.143181056789868 708 25236497
SGTC_2030 5175110 200 µM 1.06501362518553 0.143866637191106 no 492 0.143434882004631 728 2831986
SGTC_859 0439-0102 54.6 µM 1.06192614867807 0.144543204336901 no 493 0.144134606577718 813 610143
SGTC_3264 9137442 49.47 µM 1.05933079918292 0.145113586128289 no 494 0.144724576519074 697 17015726
SGTC_3127 9126946 49.47 µM 1.05927559411507 0.145125735015542 no 495 0.14473714327104 654 27243249
SGTC_166 k072-0058 166.424 µM 1.05856357765703 0.145282488638309 no 496 0.144899290890419 757 5846229
SGTC_3132 9126706 49.47 µM 1.05803343432066 0.145399276033051 no 497 0.145020099918715 714 850858
SGTC_2025 5147754 141 µM 1.05499775734682 0.146069233322521 no 498 0.145713175213351 741 315777 YLR208W SEC13
SGTC_943 3253-1379 105 µM 1.0533234002392 0.146439640749516 no 499 0.146096398867096 735 668464
SGTC_777 1315-0167 517 µM 1.05255778780272 0.146609222249475 no 500 0.146271856149169 701 4221767
SGTC_2565 isoliquiritigenin 100 µM 1.05159978804491 0.146821602684985 no 501 0.146491602539033 597 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_3126 9127922 49.47 µM 1.05145508357432 0.146853700373682 no 502 0.1465248141659 720 45595682
SGTC_889 0919-1524 82.7 µM 1.05116697041082 0.146917622342511 no 503 0.146590955068959 714 3905452
SGTC_37 0566-0070 1.56 µM 1.04838130644944 0.147536623608241 no 504 0.147231481354192 809 1626686
SGTC_1849 st056239 19.2 µM 1.04745864138489 0.147742033269041 no 505 0.147444048862929 748 5393181
SGTC_3179 9107801 49.47 µM 1.04740873294315 0.147753149666082 no 506 0.147455552841794 745 4818259
SGTC_574 1315-0397 40 µM 1.04696522671257 0.147851958987752 no 507 0.14755780818323 866 6794277
SGTC_1516 st013856 110 µM 1.04503430339592 0.148282667382662 no 508 0.148003557755461 721 5281404 A mutagen and neurotoxin.
SGTC_651 3253-0966 34.4 µM 1.04093369995952 0.149200122283386 no 509 0.148953159932534 783 781462
SGTC_3087 9117406 49.47 µM 1.03857260315436 0.149730102087114 no 510 0.149501776465969 739 42546093
SGTC_2469 5655019 90.81 µM 1.03840508867559 0.1497677506093 no 511 0.149540750737078 813 2788239
SGTC_330 1488-0319 80.1 µM 1.03835397764179 0.149779238962445 no 512 0.149552643687688 759 6846614
SGTC_1369 1866-0067 208 µM 1.03760241339899 0.149948237785399 no 513 0.149727596937284 833 3531355
SGTC_1901 st060216 58.6 µM 1.03638975942907 0.150221186531598 no 514 0.150010172962459 771 688792
SGTC_2950 9072895 21.46 µM 1.033895394537 0.150783668136777 no 515 0.150592534137833 759 17332245
SGTC_168 3970-0862 530.542 µM 1.03339576887512 0.15089650253259 no 516 0.150709362867696 904 3135186
SGTC_94 0334-0113 514.748 µM 1.03127884326815 0.151375207928829 no 517 0.151205038354462 782 6795178
SGTC_2964 9083345 53.42 µM 1.02989345708816 0.151689034729674 no 518 0.15153001124833 706 17741579
SGTC_3225 9130819 49.47 µM 1.02774283425781 0.152177064042028 no 519 0.152035406529119 777 4547121
SGTC_1531 st059297 52.4 µM 1.02685343819333 0.152379194317811 no 520 0.152244741016642 790 7566702
SGTC_1109 tnp00067 928.257 nM 1.02605424308986 0.152560976841188 no 521 0.152433008328641 775 676295
SGTC_1142 3253-1408 9.78 µM 1.02477320419332 0.152852658156265 no 522 0.15273510633335 773 256655
SGTC_2643 anethole 100 µM 1.02384137781218 0.153065059025951 no 523 0.152955101431809 817 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1330 1469-0054 61.8 µM 1.0227963031941 0.15330350638515 no 524 0.153202083148154 833 7102664
SGTC_1759 st043059 70 µM 1.01904043941438 0.154162486142761 no 525 0.154091884202681 784 669426
SGTC_2063 5246145 200 µM 1.01840373052566 0.154308418769399 no 526 0.154243065032948 795 711240
SGTC_2015 5119600 184 µM 1.01072694493034 0.156075113951468 no 527 0.156073568493103 801 2828786
SGTC_3218 9131285 49.47 µM 1.01005536011175 0.156230300526806 no 528 0.156234383816467 870 17156417
SGTC_288 1315-0019 35.1 µM 1.00656876472561 0.157037599418329 no 529 0.157071025491587 815 6811474
SGTC_796 1234-0020 70.7 µM 1.00625792312311 0.157109705788419 no 530 0.157145757689069 752 46495034
SGTC_1103 duloxetine 36.1 µM 1.00588019106211 0.157197358136308 no 531 0.157236603083922 873 60835 A selective serotonin reuptake inhibitor.
SGTC_2978 9011784 42.97 µM 1.00553982706178 0.157276366799023 no 532 0.157318490947159 890 2994934
SGTC_1189 1431-2119 7.28 µM 0.998146591725725 0.158998999510426 no 533 0.159104140073683 834 3107275
SGTC_449 xestospongin c 11.1929 µM 0.997594743058425 0.159128074890831 no 534 0.159237955627482 823 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1271 0832-2808 169 µM 0.997199597740966 0.159220540091425 no 535 0.159333818091577 845 3663794
SGTC_2271 7849410 118.62 µM 0.9944216930186 0.15987157127877 no 536 0.160008805656862 817 972430
SGTC_1153 4055-0057 267 µM 0.994048854163615 0.159959082333561 no 537 0.160099541810021 814 882706
SGTC_2069 5228469 200 µM 0.993929130113607 0.159987190066585 no 538 0.160128685660228 765 2835210
SGTC_527 4476-4215 268 µM 0.989870013842588 0.160942063775413 no 539 0.161118828917464 801 4418754
SGTC_1891 st059073 26.2 µM 0.989745877369012 0.160971324362165 no 540 0.161149172442025 885 688754
SGTC_1777 st045864 34.765 µM 0.988421952417197 0.161283606722473 no 541 0.161473020361684 836 4691462
SGTC_3073 9114972 49.47 µM 0.98593789288776 0.161870602793239 no 542 0.162081795378123 757 41905075
SGTC_332 4112-0506 40.9 µM 0.98401445076122 0.162326077048752 no 543 0.162554203873135 821 2790355
SGTC_2016 5121758 140 µM 0.971438305911946 0.165324665976105 no 544 0.165665030522611 882 2795203
SGTC_2796 7949634 45.45 µM 0.97122784461057 0.165375150271991 no 545 0.165717415470179 779 2971588
SGTC_2722 naftopidil 47.16 µM 0.971079219172898 0.165410807730377 no 546 0.165754415590898 854 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_75 0159-0059 199.013 µM 0.97032121247869 0.165592742204969 no 547 0.165943203503216 804 5377270
SGTC_1803 st050068 52.4 µM 0.970004859672767 0.165668710510612 no 548 0.166022034901549 963 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1868 st057644 42.7 µM 0.959498352020566 0.168204519466307 no 549 0.168653874738376 908 688665
SGTC_3273 9137859 49.47 µM 0.959409601737129 0.168226045690545 no 550 0.168676219951538 854 2377234
SGTC_742 0kpi-0133 140 µM 0.956165300801654 0.169014161485366 no 551 0.169494363826478 880 2728852
SGTC_322 k048-0136 19.3 µM 0.956115940403235 0.169026170554406 no 552 0.169506831104764 803 6823282
SGTC_269 exalamide 29 µM 0.953517530380683 0.169659120781736 no 553 0.170163959187263 844 3316 A derivative of salicylamide.
SGTC_381 3461-2219 42.7 µM 0.95078121627798 0.170327304573661 no 554 0.170857724889639 871 2883159
SGTC_851 0394-0702 453 µM 0.950031695519348 0.170510624654196 no 555 0.171048073895976 902 762646
SGTC_2728 chlorpromazine 9.18 µM 0.949600503218999 0.17061614421322 no 556 0.171157641343399 765 2726 A thorazine and dopamine antagonist.
SGTC_2847 9005661 71.43 µM 0.948860707458958 0.170797281277166 no 557 0.171345730528963 763 2991449
SGTC_1714 st033236 13.627 µM 0.948817640886528 0.170807829804562 no 558 0.17135668404706 863 2916566
SGTC_3210 9128157 49.47 µM 0.94847213409639 0.170892471731211 no 559 0.171444576171258 754 17590849
SGTC_2540 epiandrosterone 100 µM 0.945242795947612 0.171684889247624 no 560 0.172267467690012 1035 441302 A steroid.
SGTC_3049 9092223 49.47 µM 0.942591627255007 0.172337186686061 no 561 0.172944912048391 828 8623917
SGTC_3284 9108171 64.8615 µM 0.942168967957371 0.172441324333964 no 562 0.173053069447453 816 8687505
SGTC_3168 9103419 49.47 µM 0.940970850242918 0.172736742748315 no 563 0.173359898741086 802 16649256
SGTC_1670 st016595 4.04 µM 0.934091687131369 0.17443916802041 no 564 0.175128299818163 904 597879
SGTC_18 0111-0177 500 nM 0.933977559635884 0.174467501374424 no 565 0.175157734314544 968 721752
SGTC_2775 cyproheptadine 69.59 µM 0.933705438387627 0.17453507013664 no 566 0.175227929464969 879 2913 A selective serotonin reuptake inhibitor.
SGTC_2827 7993847 71.43 µM 0.932745149897766 0.174773646278072 no 567 0.175475783619502 791 2985692
SGTC_1683 st010134 710 nM 0.931500590665943 0.175083155098787 no 568 0.175797339599953 851 3818134
SGTC_3327 9140648 26.9345 µM 0.930788261142507 0.175260460337108 no 569 0.175981551571017 874 8029710
SGTC_2926 9010726 65.15 µM 0.930768663327429 0.175265340018771 no 570 0.175986621390836 847 2994293
SGTC_1066 ketoconazole 628 nM 0.92995364982109 0.175468347422793 no 571 0.176197541663531 934 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_464 bw-b 70c 158 µM 0.928740264234083 0.175770859232487 no 572 0.176511854351641 917 5353454
SGTC_1792 st045773 43.6 µM 0.926974976525662 0.176211556538038 no 573 0.176969763377357 849 2919270
SGTC_869 0564-0080 44.1 µM 0.926213305666327 0.176401920516017 no 574 0.177167569551241 857 6843321
SGTC_3314 9135860 59.4275 µM 0.925399396336256 0.176605484164601 no 575 0.17737909635766 921 25252478
SGTC_2558 carylophyllene oxide 100 µM 0.925065975023998 0.176688917726877 no 576 0.177465795205709 933 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_220 paclitaxel 373.376 µM 0.924519480758729 0.176825723413006 no 577 0.177607956812178 816 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3095 9117207 49.47 µM 0.922269139363513 0.177389763920863 no 578 0.178194103526909 839 17015229
SGTC_2307 7538926 6.34 µM 0.919452326036251 0.178097387598784 no 579 0.178929515368661 891 96582
SGTC_2168 5727979 200 µM 0.919063262607583 0.178195265562965 no 580 0.179031241722808 823 695210
SGTC_802 4112-3352 742 µM 0.916865786746679 0.178748728130743 no 581 0.179606487072873 939 704594
SGTC_39 0986-0283 58.349 µM 0.91253371943646 0.17984298072198 no 582 0.180743913723567 961 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_524 r073-0010 27.8 µM 0.912074148355254 0.179959311803692 no 583 0.180864842996533 864 2772106
SGTC_196 k015-0023 18.111 µM 0.910608681332203 0.180330580497647 no 584 0.181250797355765 919 5211998
SGTC_2994 9053520 71.4286 µM 0.910058810208603 0.180470011493084 no 585 0.181395747757997 901 4647384
SGTC_2995 9067767 71.4286 µM 0.908210487288979 0.180939186859984 no 586 0.181883512163815 834 11673567
SGTC_557 1315-0110 16.2 µM 0.907207964781587 0.181193985031905 no 587 0.182148416310545 928 6833801
SGTC_782 0083-0095 30.5 µM 0.906272094011287 0.181432045909725 no 588 0.182395926096608 944 3591729 An indicator and reagent.
SGTC_2324 6149169 200 µM 0.90538724428867 0.181657308374593 no 589 0.182630135497739 864 2888231
SGTC_3181 9108277 49.47 µM 0.903307294577495 0.182187504722614 no 590 0.183181413066671 889 17097298
SGTC_1497 4476-2978 41.3 µM 0.902151321140868 0.182482589612654 no 591 0.183488244777819 955 1528379
SGTC_1176 0848-0131 83.3 µM 0.901204026543675 0.182724627572232 no 592 0.183739925239962 975 6769040
SGTC_3135 9127742 49.47 µM 0.900984093793251 0.182780850018121 no 593 0.183798388471359 852 3643468
SGTC_757 1066-0008 322 µM 0.900865736475575 0.182811110726235 no 594 0.183829855389625 922 6842497
SGTC_1933 st074711 15.9 µM 0.899816895164677 0.183079407206238 no 595 0.184108850857086 971 17250958
SGTC_2044 5102272 200 µM 0.899656197094069 0.183120535903811 no 596 0.184151620381684 840 592666
SGTC_1755 st041960 45.185 µM 0.897782926059924 0.183600401732888 no 597 0.18465064449176 908 2257073
SGTC_3157 9099274 49.47 µM 0.896335404871364 0.183971741699969 no 598 0.185036827636026 908 17217662
SGTC_2598 perillyl alcohol 100 µM 0.894972690723957 0.18432175272878 no 599 0.185400843355262 927 10819 An apoptosis inducer.
SGTC_905 2-aminofluorene 215 µM 0.893644569297489 0.184663277077256 no 600 0.185756045926761 978 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.892719383108709 0.184901419609463 no 601 0.186003733815569 895 6708514
SGTC_3276 9139060 49.47 µM 0.891955625028807 0.185098154353473 no 602 0.186208358898493 906 4870619
SGTC_1518 st038567 90.8 µM 0.891210439115898 0.185290230409569 no 603 0.186408142551341 914 77966
SGTC_289 k017-0060 526 µM 0.890735587314583 0.185412690792259 no 604 0.186535519115044 918 5512909
SGTC_921 1561-0023 372 µM 0.887812123526485 0.186167734477448 no 605 0.187320910221412 948 24050882
SGTC_272 doxorubicin 8.13 µM 0.887652520893185 0.186209009870654 no 606 0.187363846379331 991 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2805 7950783 58.44 µM 0.887576761371867 0.186228604289198 no 607 0.187384229267255 950 1178958 YDL195W SEC31
SGTC_2587 piperic acid 92.2 µM 0.886366901744451 0.186541695110582 no 608 0.187709924332279 845 5370536
SGTC_187 1488-2104 32.728 µM 0.885419069483492 0.186787205341576 no 609 0.187965325576296 969 2852859
SGTC_3348 9149464 3.537 µM 0.88493872733089 0.18691170126624 no 610 0.1880948396162 930 1951442
SGTC_3246 9135460 32.98 µM 0.884139160675793 0.187119048195827 no 611 0.188310547863788 864 41446951
SGTC_2266 7929956 200 µM 0.883180494500191 0.187367840934453 no 612 0.188569379301684 923 2967153
SGTC_2940 9060638 45.86 µM 0.882841859450829 0.187455772245304 no 613 0.188660860189427 897 4027022
SGTC_87 0100-0052 35.5 µM 0.882210624623362 0.187619749235301 no 614 0.18883145873741 1091 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_534 k292-0788 63.4 µM 0.880295429438114 0.188117804993002 no 615 0.189349643987852 1016 4146317
SGTC_2008 4012253 172 µM 0.880122902857215 0.188162711392985 no 616 0.18939636662091 946 603940
SGTC_755 1995-0008 37.3 µM 0.879398305490243 0.188351386785491 no 617 0.18959267528675 953 689533
SGTC_1277 0873-0036 22 µM 0.878451673188763 0.188598052838723 no 618 0.18984932640098 970 5965735
SGTC_274 sirtinol 40.1 µM 0.878185352263407 0.18866748454752 no 619 0.189921569862802 927 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2349 9023730 187.07 µM 0.877432948627616 0.188863726509777 no 620 0.190125761701708 929 4126287
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.875971420498972 0.189245281650544 no 621 0.190522785377942 916 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1870 st057514 26.5 µM 0.875188865493031 0.189449775015667 no 622 0.190735575296791 916 5393161
SGTC_1087 pterostilbene 9.05 µM 0.874271464907625 0.189689678633455 no 623 0.190985217635383 968 5281727 Similar to reservatol, lowers cholesterol.
SGTC_417 st075190 100 µM 0.874189358203781 0.189711158944105 no 624 0.191007570214882 974 222757
SGTC_352 k048-0007 5.11 µM 0.873774686149999 0.189819666054398 no 625 0.191120484292401 978 6811911
SGTC_630 4356-0227 183 µM 0.873097158134047 0.189997036700177 no 626 0.191305061382933 907 779312
SGTC_232 clozapine 119 µM 0.8715829776772 0.19039380340486 no 627 0.191717960157874 932 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1743 st037606 46.3785 µM 0.87004685250995 0.190796839920934 no 628 0.192137400177201 918 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_748 act1.228 77.9 µM 0.869887634644183 0.19083864418213 no 629 0.19218090681212 951 4421505 YNR035C ARC35
SGTC_2406 ethylparaben 405.7 µM 0.869463890405585 0.190949929896485 no 630 0.192296725225349 791 8434 A possible steroid mimic.
SGTC_1286 0929-0070 131 µM 0.866100109814799 0.191834753396106 no 631 0.193217632494992 974 1420408
SGTC_3213 9129884 49.47 µM 0.86563970090257 0.191956056361145 no 632 0.193343888439508 888 17190742
SGTC_991 3996-0057 64.7 µM 0.865083846997733 0.192102568555605 no 633 0.193496384911651 906 715343
SGTC_1500 4488-1866 171 µM 0.863980636504633 0.19239355580937 no 634 0.193799263883665 1032 2900003
SGTC_1807 st050092 58.9 µM 0.861898686189151 0.192943433188875 no 635 0.194371636024768 911 5008496
SGTC_1936 st074407 74.3 µM 0.858632744886333 0.193807953554431 no 636 0.195271583230926 1020 809813
SGTC_1731 st035964 63 µM 0.858000434644265 0.193975603480669 no 637 0.195446111711594 909 6739575
SGTC_1472 k841-0093 193 µM 0.855335230971869 0.194683222897575 no 638 0.19618279440307 1016 X1472
SGTC_1456 k015-0012 13 µM 0.855314395255815 0.19468876102118 no 639 0.196188560179536 1047 2989616
SGTC_126 0417-1624 672.48 µM 0.854240605575075 0.194974303556956 no 640 0.196485844382666 1116 41912 YDL195W SEC31
SGTC_347 4534-1311 26.2 µM 0.85173267697143 0.195642203983398 no 641 0.197181239865805 977 2862016
SGTC_2678 equilin 100 µM 0.850503772525846 0.19596998683379 no 642 0.197522531959377 1011 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2229 7354935 190 µM 0.850003307290601 0.196103570185592 no 643 0.197661623747183 944 318112
SGTC_606 k015-0008 38.6 µM 0.849792440088076 0.196159871042765 no 644 0.197720246730816 1049 1970475
SGTC_8 0354-0001 70 µM 0.848571318568566 0.196486099213637 no 645 0.198059936076615 1053 4993152
SGTC_33 0986-0033 35.816 µM 0.847946567282425 0.196653131418791 no 646 0.198233864433688 945 2848082
SGTC_1848 st056003 16.4 µM 0.847094064117828 0.196881193606046 no 647 0.198471346720011 1060 146492
SGTC_3334 9142812 21.919 µM 0.842182780605787 0.198198179182828 no 648 0.199842825366609 950 45283678
SGTC_3059 1327-0034 3 µM 0.842136341158186 0.198210657483291 no 649 0.199855820752534 937 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2850 9015429 58.44 µM 0.839696187986242 0.198866994694713 no 650 0.200539375945793 960 6457570
SGTC_81 0411-0046 9.971 µM 0.839268863052021 0.198982068543025 no 651 0.200659225914901 905 12925265
SGTC_3104 9120930 49.47 µM 0.838614090470273 0.19915846933827 no 652 0.200842950539787 933 17014836
SGTC_1015 4130-4525 82 µM 0.837703750130017 0.199403878532678 no 653 0.201098553370842 979 1363237
SGTC_2049 5262831 67.185 µM 0.836475746212929 0.199735211636893 no 654 0.201443657820298 984 763417
SGTC_840 0245-0196 390 µM 0.83597784829942 0.199869645963346 no 655 0.201583682529105 1025 3827528
SGTC_2628 lathosterol 100 µM 0.834184482820462 0.200354312260841 no 656 0.202088516921227 1013 6710616
SGTC_3297 9117502 71.43 µM 0.832234850007171 0.200882010847921 no 657 0.202638198178069 1000 7453720
SGTC_2274 7947094 46.08 µM 0.831758558217323 0.201011053308671 no 658 0.20277262001289 1060 2971028
SGTC_2915 7971052 15.16 µM 0.831175980840444 0.201168959475921 no 659 0.20293711080025 857 5741558
SGTC_977 1348-1378 135 µM 0.830265759239971 0.201415821652069 no 660 0.203194271443596 1053 X977
SGTC_747 3448-8087 38.7 µM 0.829317855418896 0.201673096552982 no 661 0.203462284923106 995 5168703
SGTC_2618 avocadyne 43.43 µM 0.82422099844064 0.203059829067953 no 662 0.204906998886251 984 3015189
SGTC_2571 chrysanthemic acid 100 µM 0.82176552365512 0.203729932052429 no 663 0.205605179514296 945 2743 An insecticide.
SGTC_2980 9014342 25.29 µM 0.819143823903413 0.204446851387098 no 664 0.20635218055919 930 2996599
SGTC_3171 9103192 49.47 µM 0.818677282317793 0.204574587149364 no 665 0.206485280645919 1079 13018434
SGTC_1040 k898-0338 155 µM 0.818241630955307 0.204693908253552 no 666 0.206609613940495 1076 20969351
SGTC_3155 9099265 49.47 µM 0.816869494494249 0.205069994898136 no 667 0.207001506279417 932 25236499
SGTC_989 1501-0895 10.3 µM 0.815534468292437 0.205436303941321 no 668 0.207383221487605 1025 2830112
SGTC_3054 9094397 49.47 µM 0.814986488079232 0.205586773032328 no 669 0.207540022226142 1064 2598354
SGTC_291 SEC14.278 35.5 µM 0.810329019920494 0.206868299440266 no 670 0.208875550379636 1044 1068044
SGTC_2033 5192550 145 µM 0.810061740696416 0.206941985875399 no 671 0.208952345959424 1024 182073
SGTC_2172 5754775 163.918 µM 0.808706882604478 0.207315746711252 no 672 0.20934188416804 960 2263357
SGTC_2436 5633522 8.09 µM 0.80785298260028 0.207551514587967 no 673 0.209587610225377 1048 5724242
SGTC_2444 5485484 36.41 µM 0.807735885460243 0.207583858292605 no 674 0.209621320389227 1069 6790631
SGTC_1748 st037455 53.6035 µM 0.806371851926628 0.207960840901616 no 675 0.210014236012254 1005 580690
SGTC_2362 9071156 126 µM 0.805840088873705 0.208107915507864 no 676 0.210167529766927 1005 653133
SGTC_1591 genipin 88.4 µM 0.804104152358712 0.208588466582492 no 677 0.210668413342482 981 442424 A DNA cross-linking agent.
SGTC_130 0136-0219 337.655 µM 0.803911913214235 0.208641723437988 no 678 0.210723924672756 1016 234244
SGTC_1587 estradiol valerate 56.1 µM 0.801314531395747 0.209362072963797 no 679 0.211474790215589 1048 13791 A steroid.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.799692159560035 0.209812757999208 no 680 0.211944588339079 1079 5393153
SGTC_205 1486-1330 71.903 µM 0.799534367408355 0.209856622111677 no 681 0.211990313533771 1011 4118834
SGTC_1862 st057513 3.81 µM 0.799087174080597 0.209980965171213 no 682 0.212119933082482 1062 5393163
SGTC_2888 9058547 12.99 µM 0.795496963772999 0.210980798751379 no 683 0.213162238212764 943 16476514
SGTC_1173 0443-0020 122 µM 0.794067431216649 0.21137968326295 no 684 0.213578088309464 1034 5331295
SGTC_1357 1503-1303 39.5 µM 0.791878688074449 0.21199126649984 no 685 0.214215707360571 1086 292895
SGTC_1821 st053465 65.6 µM 0.791405931281942 0.212123500981951 no 686 0.21435357495523 1022 675086
SGTC_1640 st009078 66.4 µM 0.790973558186788 0.212244481980293 no 687 0.214479710832823 1000 690618
SGTC_3330 9141424 71.43 µM 0.788526515372626 0.212929941215299 no 688 0.215194397609759 1077 27261020
SGTC_103 0844-0104 51.839 µM 0.787956994369222 0.213089659074576 no 689 0.215360930793656 1126 5375804
SGTC_3043 9092303 49.47 µM 0.787462528758341 0.213228384878216 no 690 0.215505577713036 1031 25236084
SGTC_562 3772-2733 112 µM 0.786816063741483 0.213409834600498 no 691 0.215694774260709 1105 2876874 YIL048W NEO1
SGTC_250 brefeldin a 552.239 µM 0.786711028655498 0.213439324333131 no 692 0.215725523260739 961 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2051 5263410 176 µM 0.785818339429777 0.213690052314673 no 693 0.215986960404407 1133 227584
SGTC_495 decylubiquinone 155 µM 0.78478965265743 0.213979190336028 no 694 0.216288453934308 1033 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_920 mycophenolic acid 780.421 nM 0.783548071478477 0.214328470762613 no 695 0.216652668088582 1022 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2918 7977171 22.06 µM 0.783082927731233 0.214459409895493 no 696 0.216789207918867 1045 2236483
SGTC_2870 9038528 12.99 µM 0.781868613117645 0.21480146164235 no 697 0.217145896246951 1003 6463316
SGTC_2957 9076800 11.52 µM 0.781777170023686 0.214827232431052 no 698 0.217172770126775 1001 16459615
SGTC_2768 sulfasalazine 50.2 µM 0.781560648297929 0.214888260445913 no 699 0.217236410573091 1096 5384001 An antioxidant and salicylic acid derivative.
SGTC_1275 0867-0008 21.1 µM 0.781085679414144 0.215022168692037 no 700 0.2173760519879 1068 3422836
SGTC_316 k060-0003 58.6 µM 0.779475330960398 0.215476535618791 no 701 0.217849881916363 1063 6152314
SGTC_3112 9123419 49.47 µM 0.77834141597008 0.21579680860804 no 702 0.218183882865811 1127 17015854
SGTC_2789 5281112 71.43 µM 0.775497591588906 0.216601256177633 no 703 0.219022844027261 1061 765948
SGTC_2105 5350118 200 µM 0.775112487449632 0.216710325819993 no 704 0.219136596671261 1095 2133313
SGTC_668 1682-0499 62.6 µM 0.775036845194011 0.216731753039211 no 705 0.219158943985852 1094 682214
SGTC_251 melphalan 456.522 µM 0.772398175021175 0.217479976918944 no 706 0.219939317215239 1173 460612 A DNA alkylator.
SGTC_390 dec-rvkr-cmk 16.7 µM 0.772210020841763 0.217533386994553 no 707 0.21999502369015 1113 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_684 1140-0066 328 µM 0.771868313195888 0.217630404628889 no 708 0.220096213166417 1117 6813534
SGTC_2088 5278280 127.392 µM 0.770530489643023 0.218010479641768 no 709 0.220492638034932 1120 791502
SGTC_1146 3579-1023 7 µM 0.769734747910123 0.218236730861933 no 710 0.220728626755068 1121 X1146
SGTC_2809 7964133 12.99 µM 0.769435596281022 0.218321822862393 no 711 0.220817381896855 1061 1253665
SGTC_2867 9039098 71.43 µM 0.768341337831324 0.218633241309875 no 712 0.22114221090236 1079 6463460
SGTC_544 k015-0020 52.4 µM 0.767109105369871 0.218984232132276 no 713 0.221508324347735 1066 3008304
SGTC_1342 1486-1464 234 µM 0.766870212443052 0.219052316215545 no 714 0.221579342843297 1126 3253938
SGTC_140 0062-0056 502.533 µM 0.766616019630264 0.219124774106268 no 715 0.221654924003404 1124 3758964
SGTC_1659 st012954 42.1 µM 0.766417141320772 0.219181474155339 no 716 0.221714068335284 1050 24207262
SGTC_1575 cyproterone acetate 48 µM 0.76407874461424 0.219848781532688 no 717 0.222410159037167 1058 9880 An androgen receptor antagonist and liver toxin.
SGTC_1722 st034304 3.6505 µM 0.763291248108726 0.220073771311445 no 718 0.222644860187102 1120 4036148 YLR033W RSC58
SGTC_3278 9139605 49.47 µM 0.762254486166923 0.220370178180813 no 719 0.222954066224442 1102 7958859
SGTC_3250 9135583 49.47 µM 0.761294561461729 0.220644821449873 no 720 0.223240574117986 1075 7699353
SGTC_114 0364-0001 490.298 µM 0.76079584657792 0.220787585716442 no 721 0.223389507799816 1114 4003655
SGTC_3336 9143619 71.43 µM 0.759728355443727 0.22109334804178 no 722 0.223708487879756 1126 45595730
SGTC_861 0443-0273 110 µM 0.758695973282332 0.22138928441889 no 723 0.224017223119915 1102 6149169
SGTC_1396 3511-0007 98.6 µM 0.758399195724871 0.221474398760147 no 724 0.224106019611467 1033 X1396
SGTC_611 3453-1652 23.7 µM 0.75741804289015 0.221755921675764 no 725 0.224399724932233 1120 1560575
SGTC_925 2064-1272 59.6 µM 0.7573349574604 0.221779770825522 no 726 0.224424606349683 1025 6815817
SGTC_2828 7998861 71.43 µM 0.756692287127653 0.221964294792482 no 727 0.224617118359077 1021 2988188
SGTC_58 0957-0393 9 µM 0.754600822803366 0.22256540400849 no 728 0.225244264920662 1108 6997992
SGTC_2638 epoxomicin 18 µM 0.754037510887358 0.222727464393609 no 729 0.225413349026357 1092 9915668 A protesome inhibitor.
SGTC_2466 5983409 37.09 µM 0.752919123722152 0.223049414766645 no 730 0.225749257778583 1050 2879657
SGTC_1557 sumaresinolic acid 42.3 µM 0.751835963631493 0.223361476786938 no 731 0.226074855787511 1074 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2309 7664088 163.95 µM 0.750657388061564 0.223701310378631 no 732 0.22642943703254 1130 704922
SGTC_2746 daunorubicin 9.88 µM 0.749329499591492 0.224084549194624 no 733 0.226829315909995 1012 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3013 9080133 71.4286 µM 0.748783468612583 0.224242246070835 no 734 0.226993862600899 1169 17050193
SGTC_3145 9085516 49.47 µM 0.748239497117433 0.224399410793556 no 735 0.227157855575359 1128 25236195
SGTC_1441 4106-0040 13 µM 0.74729099269798 0.224673603015616 no 736 0.227443964178013 1127 2904180
SGTC_2330 7979373 200 µM 0.746784789890353 0.224820013091193 no 737 0.227596739147512 1103 1863007
SGTC_1596 piperlongumine 63 µM 0.744837959027809 0.22538360278983 no 738 0.228184842219112 1149 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1258 0671-0043 57.1 µM 0.743705662894222 0.225711759720391 no 739 0.228527281378579 1135 4298767
SGTC_1778 st046819 58.9 µM 0.743632107578541 0.225733086534128 no 740 0.228549536618406 1192 671715
SGTC_53 0973-0023 39.979 µM 0.74346043069126 0.225782867398694 no 741 0.228601484715476 1111 674768
SGTC_413 propylparaben 100 µM 0.742201570936702 0.226148086539146 no 742 0.228982608464448 1108 7175 A pharmaceutical preservative.
SGTC_3303 9125618 40.5795 µM 0.741691131881667 0.226296269684266 no 743 0.229137247023275 1156 22695467
SGTC_1746 st038117 42 µM 0.740832523140596 0.226545652007521 no 744 0.229397496381329 1109 2898218
SGTC_2868 9035608 32.47 µM 0.738618198103256 0.227189516699576 no 745 0.230069435327313 1147 6462614
SGTC_443 clozapine 122 µM 0.736489390067136 0.227809486642624 no 746 0.230716461066269 1044 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2737 bleomycin 30.5 nM 0.73630943487964 0.227861938360458 no 747 0.23077120284955 1178 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1809 st050081 57.6 µM 0.73625661314901 0.227877335652867 no 748 0.230787272425505 1171 5036894
SGTC_1990 st072050 59.8 µM 0.736224062410834 0.227886824335396 no 749 0.23079717541416 1167 17233948
SGTC_1767 st044992 70.3 µM 0.736181679988189 0.227899179330097 no 750 0.230810069875284 1134 9600693
SGTC_1247 0448-0043 5.84 µM 0.734920745847024 0.228266929410187 no 751 0.231193881453377 1148 3089013 YGL099W LSG1
SGTC_2749 bexarotene 57.39 µM 0.734476988257367 0.228396430140292 no 752 0.231329040025101 1129 82146 An retinoic acid receptor inhibitor.
SGTC_1622 st003707 19.4 µM 0.734310999904016 0.228444880736846 no 753 0.231379607663904 1134 10140899
SGTC_63 0099-0242 26.702 µM 0.734184337449611 0.228481856320336 no 754 0.231418198982943 1163 3898502 YLR359W ADE13
SGTC_1479 0549-0158 134 µM 0.732539021523666 0.228962465969955 no 755 0.23191981726453 1203 5440202
SGTC_3349 9149703 23.001 µM 0.732003308609183 0.229119074235692 no 756 0.232083274163698 1153 4910494
SGTC_202 3594-0513 34.79 µM 0.731391516373234 0.229297996703576 no 757 0.232270022823761 1125 708429
SGTC_1613 st002381 52.1 µM 0.731167001718755 0.229363677062377 no 758 0.232338576550485 1158 551167
SGTC_1602 st001878 87.6 µM 0.731131858555325 0.229373958929654 no 759 0.232349308248834 1124 595405 YLR310C CDC25
SGTC_2178 5812956 200 µM 0.730306561482777 0.229615491106239 no 760 0.232601409193426 1148 5403383
SGTC_520 3584-0023 682 µM 0.730084263842261 0.229680573280143 no 761 0.23266933975312 1075 1340790
SGTC_2866 9034245 58.44 µM 0.729828406302125 0.229755493587853 no 762 0.232747539322877 1145 6462273
SGTC_2502 avocadyne acetate 18.59 µM 0.728769960923566 0.230065573354904 no 763 0.233071194694509 1166 3952079
SGTC_3020 9089140 49.47 µM 0.728711010018209 0.230082850360399 no 764 0.233089228266008 1168 17217859
SGTC_1885 st057546 99.9 µM 0.726276630349604 0.230796938539347 no 765 0.233834601418038 1177 702008
SGTC_892 0929-0076 29 µM 0.725549492509981 0.231010473177113 no 766 0.234057496824061 1181 5751038
SGTC_561 1550-0330 72.9 µM 0.725389735358647 0.231057402968006 no 767 0.234106484230026 1120 6812934
SGTC_2834 9001755 58.44 µM 0.723894204620167 0.231496983649179 no 768 0.234565344096682 1051 2989575
SGTC_2690 usnic acid 100 µM 0.72367849064919 0.231560426812934 no 769 0.234631570647287 1194 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1097 itavastatin 7.23 µM 0.722861598174162 0.231800769094666 no 770 0.234882459281342 1194 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2370 9071495 200 µM 0.719837059203445 0.232691843471647 no 771 0.235812662251155 1109 21791103
SGTC_3146 9095609 49.47 µM 0.719294773511588 0.232851809977534 no 772 0.235979657752869 1145 17173999
SGTC_1711 st032263 62.8 µM 0.71907266388526 0.232917346766077 no 773 0.236048074656791 1149 3958979
SGTC_2145 5634607 200 µM 0.718837155489063 0.232986848253848 no 774 0.236120630749123 1134 308662
SGTC_1701 st028638 40.4 µM 0.71736224459383 0.233422374835919 no 775 0.236575304754396 1152 3490878
SGTC_3111 9122088 49.47 µM 0.715965611621159 0.233835202713345 no 776 0.237006291541695 1078 16876704
SGTC_1214 0358-0031 63.7 µM 0.714872091591013 0.234158716272074 no 777 0.237344041729629 1161 4301366
SGTC_1657 st012939 43.4 µM 0.714730372426699 0.234200661456979 no 778 0.237387833173329 1170 24207257
SGTC_903 1134-0042 114 µM 0.714095954074412 0.234388483764455 no 779 0.237583923807806 1180 701009
SGTC_1623 st003709 20.3 µM 0.712237584376202 0.234939141575575 no 780 0.238158833431197 1170 16192618
SGTC_2289 7946404 165.07 µM 0.711586013680942 0.235132379117138 no 781 0.238360585216355 1224 1246120 YPR165W RHO1
SGTC_1690 st023502 41.2 µM 0.710217755731754 0.235538451508281 no 782 0.238784555905357 1141 24207482
SGTC_691 1548-0686 185 µM 0.70952101656314 0.235745378746087 no 783 0.239000607081179 1153 46495133
SGTC_1242 0402-0103 60.1 µM 0.709061729342437 0.235881839020648 no 784 0.239143085437695 1152 432868
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.708493672654293 0.236050676347129 no 785 0.239319370042581 1140 688662
SGTC_46 0329-0187a 2.197 µM 0.708284923638996 0.236112737278486 no 786 0.239384168799097 1188 46494817
SGTC_2517 totarol 10 µM 0.707613788929327 0.236312326034783 no 787 0.239592563772219 1140 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_209 4077-0173 175.592 µM 0.706213581126757 0.236729032764732 no 788 0.240027662898607 1132 15993494
SGTC_418 lividomycin a 100 µM 0.705938554457936 0.236810929122907 no 789 0.240113174993695 1201 72394 An antibiotic.
SGTC_3044 9093193 49.47 µM 0.704873982420412 0.237128080009663 no 790 0.240444331335625 1155 25236277
SGTC_1400 3771-8998 51.5 µM 0.702582632816821 0.237811496098615 no 791 0.241157944379733 1140 670767
SGTC_1068 loratadine 26.9 µM 0.700427819977121 0.238455173198011 no 792 0.241830083757657 1182 3957 A H1 histamine antagonist.
SGTC_3075 9116269 49.47 µM 0.700017818060383 0.23857775526292 no 793 0.241958088498331 1195 17015205 YNL244C SUI1
SGTC_235 0330-0087 5 mM 0.699415140632983 0.238758005902049 no 794 0.242146314238983 1222 46494818 YHR062C RPP1
SGTC_1997 st073024 93.8 µM 0.696968700156121 0.23949045938499 no 795 0.242911191012627 1181 686268
SGTC_2345 9052315 157.45 µM 0.696897974874188 0.239511652453931 no 796 0.242933322614403 1186 6469265
SGTC_2576 guaiol 23.12 µM 0.696619823637604 0.239595011340368 no 797 0.243020373249812 1194 227829
SGTC_653 0203-0016 55.2 µM 0.696019871746095 0.239774864272465 no 798 0.24320819253755 1208 295302
SGTC_26 0302-0163 425.158 µM 0.694116498104449 0.240345942807216 no 799 0.243804576498505 1216 3100915
SGTC_2101 5377231 179.231 µM 0.691699647824765 0.241072148762958 no 800 0.244562984101223 1191 2844213
SGTC_2889 9059656 51.95 µM 0.688062105327286 0.242167389031669 no 801 0.245706836292888 1262 3949838
SGTC_1397 3532-0190 20.1 µM 0.68721857752715 0.24242175450089 no 802 0.24597249958587 1141 5322280
SGTC_969 1313-0238 134 µM 0.686504830730721 0.242637097563924 no 803 0.24619740956466 1230 5212874
SGTC_2377 9073351 62.6 µM 0.686190620805056 0.242731930011271 no 804 0.246296455742072 1174 7337946 YHR072W ERG7
SGTC_1065 prochlorperazine maleate 2.48 µM 0.686170182123047 0.242738099353556 no 805 0.246302899223428 1253 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1453 4237-0541 195 µM 0.686030596762512 0.242780234959208 no 806 0.246346907200377 1188 739892
SGTC_1329 1447-1697 50.6 µM 0.68584479128782 0.242836328831932 no 807 0.246405493829433 1195 2840515
SGTC_1672 st016598 6.51 µM 0.6853333741071 0.242990759689129 no 808 0.24656678817411 1177 4665860 YNL267W PIK1
SGTC_297 0986-0032 24 µM 0.684258164599365 0.243315610122919 no 809 0.246906079677823 1193 2847425
SGTC_1406 3909-7906 11.9 µM 0.684034499717418 0.243383214928376 no 810 0.246976690416065 1233 X1406
SGTC_1091 telmisartan 47.6 µM 0.683836967044583 0.243442929468273 no 811 0.247039060231103 1280 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2480 5767542 37.17 µM 0.683069294041516 0.243675073759751 no 812 0.247281528591217 1213 2867358
SGTC_1212 0520-0165 585 µM 0.682209493636364 0.243935219210248 no 813 0.247553246235494 1335 5403258
SGTC_2496 diffractaic acid 79.83 µM 0.682042928405944 0.243985633328748 no 814 0.247605903299002 1275 94870 An apoptosis inducer which activates caspases.
SGTC_1316 1272-0050 65.9 µM 0.68201170865878 0.243995083201383 no 815 0.247615773612856 1216 7340392
SGTC_2977 9011197 71.43 µM 0.680767172343104 0.244371951366167 no 816 0.248009412496376 1221 2704722
SGTC_2920 7982904 15.77 µM 0.680749362122016 0.244377346899901 no 817 0.248015048177807 1194 6456808
SGTC_2614 arthonioic acid 13.39 µM 0.679267757100647 0.244826417816822 no 818 0.248484111066314 1175 6710684
SGTC_1000 4048-0884 8.67 µM 0.678480537678647 0.245065202704086 no 819 0.248733529867623 1220 13040088
SGTC_2135 5326629 150.42 µM 0.67747443235902 0.245370563859252 no 820 0.249052493389757 1195 5020077
SGTC_368 fentichlor 4.58 µM 0.677088613588178 0.245487717219831 no 821 0.249174866430002 1192 7329 A pesticide.
SGTC_355 1311-2252 105 µM 0.676962419943394 0.24552604227489 no 822 0.24921489915649 1196 5338538
SGTC_2372 9071633 200 µM 0.674084959909794 0.246400799516886 no 823 0.250128650428034 1251 21321366
SGTC_2148 5546263 113.568 µM 0.674079833494 0.246402359453146 no 824 0.250130279930393 1220 792097
SGTC_1338 1486-1223 76 µM 0.673995483022731 0.24642802753395 no 825 0.250157092706124 1240 3444526
SGTC_490 phenamil 164 µM 0.673000506177094 0.246730909839259 no 826 0.250473484448246 1166 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_888 0916-0002 6.97 µM 0.672386877019825 0.246917804884774 no 827 0.250668717469149 1272 2802138 YIL048W NEO1
SGTC_276 colchicine 750 µM 0.672288071314717 0.246947905542932 no 828 0.250700161148049 1266 2833 A microtubule depolymerizer.
SGTC_2413 inermin 26.06 µM 0.671258445791041 0.247261692563739 no 829 0.251027950844364 1312 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_462 ag-879 158 µM 0.671225305590509 0.247271795858062 no 830 0.251038505063541 1239 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2944 9067346 25.62 µM 0.670120198247734 0.247608831007561 no 831 0.251390584992501 1188 6473075
SGTC_1874 staurosporine 7.6 µM 0.669615775576499 0.247762751136546 no 832 0.251551377450238 1248 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_601 0986-0029 62.9 µM 0.668155185984043 0.248208725143721 no 833 0.252017269049805 1237 24747981
SGTC_1198 1612-1005 86.7 µM 0.66757294588971 0.248386624635774 no 834 0.252203115937368 1298 6998509
SGTC_2140 5586273 200 µM 0.666902004190911 0.248591710550668 no 835 0.252417365341973 1233 854421
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.666115744464556 0.248832160330883 no 836 0.252668560859753 1218 2346 DNA damaging agent; causes G2/M arrest.
SGTC_463 ikarugamyin 104 µM 0.664981981700405 0.249179099517239 no 837 0.253031008872935 1288 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1693 xanthone 101.9 µM 0.664234291703602 0.249408038484727 no 838 0.253270184450265 1278 7020 An insecticide.
SGTC_320 4092-0846 5.34 µM 0.663867345014558 0.24952043662462 no 839 0.253387609034946 1227 1359356
SGTC_88 0180-0332 8.668 µM 0.661367698389916 0.250286810104164 no 840 0.254188267909143 1298 3101745
SGTC_2620 irigenin 100 µM 0.660992125753818 0.250402065692476 no 841 0.254308681681691 1283 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_3170 9103054 49.47 µM 0.66071978646943 0.250485658661041 no 842 0.254396016116361 1212 16432970
SGTC_1122 capsaicin 818.572 nM 0.660698373159102 0.250492231979846 no 843 0.254402883656126 1289 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1987 st072290 61.9 µM 0.659924512225682 0.250729848108857 no 844 0.254651136569105 1266 54697379
SGTC_3101 9120531 49.47 µM 0.659094706058987 0.250984774932078 no 845 0.254917477485222 1311 24824904
SGTC_204 PMA1.184 62.41 µM 0.65733826525502 0.251524827589479 no 846 0.255481718613735 1276 2252213 YGL008C PMA1
SGTC_2395 5646831 180.19 µM 0.656142418647711 0.251892865427555 no 847 0.255866246828272 1284 6808628
SGTC_1124 fisetin 1.16336 µM 0.653404713637343 0.252736499948739 no 848 0.25674770040622 1268 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2065 5221596 34.26 µM 0.652609757655959 0.252981747187833 no 849 0.25700394667528 1268 788581
SGTC_1028 k015-0029 4.8 µM 0.650384153615541 0.253669020827144 no 850 0.257722055298195 1263 4588309
SGTC_1876 myriocin 605 nM 0.650220116031734 0.253719714928928 no 851 0.257775024497742 1316 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1558 st069300 45.6 µM 0.649179888067858 0.25404131030513 no 852 0.258111054873043 1231 24208000
SGTC_2681 menadione 3.18 µM 0.64819236839289 0.254346808220958 no 853 0.258430268647395 1282 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3319 9138450 16.7555 µM 0.648189817914829 0.254347597483069 no 854 0.25843109334907 1253 2029690
SGTC_1468 k284-1086 134 µM 0.647164545602251 0.254664978659848 no 855 0.258762727399281 1283 15996457
SGTC_871 0574-0004 149 µM 0.646734185831098 0.254798261714219 no 856 0.258901996948368 1271 9551173
SGTC_715 0868-0130 184 µM 0.645910454676665 0.255053474268061 no 857 0.259168674268124 1333 2876258
SGTC_305 1682-2595 20.8 µM 0.644258974540381 0.255565546716182 no 858 0.259703757052999 1286 226033
SGTC_3119 9125183 49.47 µM 0.643339263714613 0.25585095297441 no 859 0.260001992150745 1143 22695334
SGTC_1728 st035614 33.7865 µM 0.643002076416235 0.255955631180557 no 860 0.260111376275343 1307 15945546
SGTC_3063 1327-0034 4 µM 0.639623569577886 0.257005705055429 no 861 0.261208677756047 1199 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_100 0086-0128 49.5915 µM 0.638803959666253 0.257260785402961 no 862 0.261475236018713 1243 93297
SGTC_3174 9107204 49.47 µM 0.638183932885661 0.257453838555601 no 863 0.261676977457039 1303 3938802
SGTC_2840 9008771 71.43 µM 0.638016433159597 0.257506004615902 no 864 0.261731491441269 1268 2992978
SGTC_2804 7954240 19.48 µM 0.637820775177789 0.257566947226101 no 865 0.261795177108769 1285 828705
SGTC_2886 9058944 51.95 µM 0.637361389544225 0.25771006389535 no 866 0.26194473600725 1164 4949929
SGTC_2094 5332512 191.667 µM 0.637101283799802 0.25779111535231 no 867 0.262029436196376 1346 755774
SGTC_206 4546-0025 72.014 µM 0.637016191983855 0.257817633654077 no 868 0.262057148331545 1286 6620745 YIL048W NEO1
SGTC_736 0958-0254 92.6 µM 0.636001637095878 0.258133922008165 no 869 0.262387677497515 1339 6812352
SGTC_833 3852-0053 558 µM 0.632363012980146 0.259269918612797 no 870 0.263574848474266 1366 3123681
SGTC_2974 9094440 9.66 µM 0.632203913310509 0.259319649211199 no 871 0.263626820267634 1383 25236134
SGTC_270 tamoxifen 5.46 µM 0.631914871722818 0.259410009029635 no 872 0.263721252504462 1387 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1630 st005209 31.3 µM 0.631814381985011 0.259441427815255 no 873 0.263754087360135 1299 3367314
SGTC_3338 9144300 39.5675 µM 0.631228861302211 0.259624533839207 no 874 0.263945446731629 1290 4901274
SGTC_2960 9079389 5.97 µM 0.628910413875244 0.260350221156996 no 875 0.264703853962869 1304 16457355
SGTC_3178 9107506 49.47 µM 0.628424025981948 0.260502595848077 no 876 0.264863100996004 1323 8897194
SGTC_1607 st000305 50.6 µM 0.627660386218596 0.2607419200988 no 877 0.265113220572574 1341 5457690
SGTC_816 0325-0417 81.3 µM 0.627214725992012 0.260881642011466 no 878 0.265259245793997 1273 68101
SGTC_1834 st055981 52.8 µM 0.627187291005577 0.26089024459536 no 879 0.265268236487528 1370 471719 YDL150W RPC53
SGTC_1810 st050138 53 µM 0.62638837764744 0.261140817863675 no 880 0.265530115459509 1303 3444541
SGTC_1852 st056254 31.4 µM 0.625074502904308 0.261553173776545 no 881 0.265961080672701 1250 442583
SGTC_475 α-linolenic acid 10 µM 0.624804583490967 0.261637928597515 no 882 0.266049661035478 1376 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2036 5160441 105 µM 0.624593844586317 0.261704110508056 no 883 0.266118830317329 1334 134534 YIL048W NEO1
SGTC_3036 9090181 49.47 µM 0.622851656209654 0.262251568302847 no 884 0.266691004605498 1338 25236586
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.621425276740574 0.26270022404732 no 885 0.267159922623762 1270 4620898
SGTC_3071 9117417 49.47 µM 0.620802862391958 0.262896122265714 no 886 0.267364669842606 1263 45595590 YGL055W OLE1
SGTC_29 0299-0004 12.984 µM 0.617079722374759 0.26406949817235 no 887 0.26859107144071 1218 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2064 5220758 200 µM 0.616771749575374 0.264166677497464 no 888 0.268692644084808 1345 788518
SGTC_1680 diphenhydramine 100 µM 0.61520463947662 0.264661453514684 no 889 0.269209792123941 1344 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_124 0136-0217 7.121 µM 0.614350826062842 0.264931222066788 no 890 0.269491761452888 1435 3976905
SGTC_2118 5526350 200 µM 0.6129956100283 0.265359699162198 no 891 0.269939621220866 1354 743594
SGTC_1491 4138-0063 26.5 µM 0.611751267966151 0.265753430856779 no 892 0.27035116813332 1298 23883227
SGTC_1391 3442-0225 151 µM 0.609321562313039 0.26652308518986 no 893 0.271155658791166 1314 5227075
SGTC_1094 duloxetine 25.4 µM 0.609000078773765 0.266625005449349 no 894 0.271262193342056 1326 60834 A selective serotonin reuptake inhibitor.
SGTC_1102 cgs 12066b 26.1 µM 0.608780909250987 0.266694500285045 no 895 0.271334834607557 1310 6438352 A 5-HT1B full agonist.
SGTC_1682 st012968 530 nM 0.607206172244192 0.267194091034034 no 896 0.271857048305099 1284 24207270
SGTC_10 0279-0212 42.575 µM 0.60490862666137 0.267923841663214 no 897 0.27261985544678 1336 39851 YBR002C RER2
SGTC_2263 7948595 193.29 µM 0.604854753565336 0.267940964970567 no 898 0.272637754570269 1334 2971371
SGTC_1645 Cervolide 78 µM 0.603572072922512 0.268348821610672 no 899 0.273064092339716 1286 23173 A fragrance.
SGTC_3058 9093861 49.47 µM 0.603124309071418 0.268491271507834 no 900 0.273212997994651 1353 17217477
SGTC_1952 st077036 64.1 µM 0.602455466256633 0.268704125411048 no 901 0.273435499241996 1332 2937007
SGTC_3299 9121982 43.1275 µM 0.601146327319755 0.26912099368262 no 902 0.273871264701437 1341 17594604 YPL160W CDC60
SGTC_1182 1222-0449 220 µM 0.601014130234897 0.269163107147499 no 903 0.273915287454784 1357 658318
SGTC_1001 4048-4355 44.4 µM 0.599755684958775 0.269564170196308 no 904 0.274334535499185 1321 21824233
SGTC_2917 7979103 53.79 µM 0.599030480011106 0.269795426944722 no 905 0.274576279597197 1392 2980565
SGTC_1504 k297-0033 30 µM 0.598486513135351 0.269968954827857 no 906 0.274757677675717 1245 4388117
SGTC_337 1315-0038 354 µM 0.597053050083073 0.270426503372366 no 907 0.275235981222655 1335 1626437
SGTC_1367 1812-0510 76.9 µM 0.596685332751514 0.270543937871937 no 908 0.275358743474074 1349 1142582 YDR527W RBA50
SGTC_1038 k292-0204 154 µM 0.596306482599687 0.270664954397209 no 909 0.2754852505861 1278 4454212
SGTC_2052 5265182 7.135 µM 0.595023039527 0.271075126852811 no 910 0.275914035237528 1397 1239884
SGTC_108 0509-0257 621.132 µM 0.59477365258642 0.271154863777156 no 911 0.275997390780769 1316 536624
SGTC_293 4049-0273 38.5 µM 0.593838875150604 0.271453845844466 no 912 0.27630994249468 1288 1380311
SGTC_1160 4092-0570 10.5 µM 0.591228416002819 0.272289651782418 no 913 0.277183692784735 1332 4994975
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.590025214259738 0.272675317944385 no 914 0.277586872663655 1238 6708630 An antioxidant.
SGTC_47 0149-0135 24.25 µM 0.587343864833005 0.273535753612202 no 915 0.278486393296912 1277 5239155
SGTC_2153 5569715 200 µM 0.585384062853117 0.274165496120232 no 916 0.279144751213214 1369 2054701
SGTC_3152 9099253 49.47 µM 0.585053253884108 0.274271865455158 no 917 0.2792559547404 1352 25236131
SGTC_366 0181-0206 4.31 µM 0.584784278991702 0.27435836748841 no 918 0.279346388217578 1417 274874
SGTC_420 mitomycin C 81.9 mM 0.583601896980712 0.274738779907709 no 919 0.279744091808938 1352 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2580 diallyl disulphide 81.36 µM 0.582226483424432 0.275181624097486 no 920 0.280207068482281 1385 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1636 st007707 68.9 µM 0.581470441980944 0.275425197619427 no 921 0.280461716897101 1413 403051
SGTC_2332 7982454 138.89 µM 0.580228467688053 0.275825554002565 no 922 0.28088027928077 1379 2981748
SGTC_2524 avocatin b 10.57 µM 0.57881128122815 0.276282739897786 no 923 0.281358259135935 1340 6710748
SGTC_2202 7226349 200 µM 0.578715417789238 0.276313678968317 no 924 0.281390605532528 1330 844334
SGTC_2462 5162487 171.77 µM 0.577549355386813 0.276690151241062 no 925 0.281784203808383 1352 2259986
SGTC_1554 st069299 38.7 µM 0.577062203827827 0.276847506295475 no 926 0.281948717823146 1369 24207999
SGTC_1195 1502-0147 41.1 µM 0.577000057476111 0.276867583369588 no 927 0.281969708347587 1356 817940
SGTC_2175 5807670 165.306 µM 0.573090172904552 0.278132146928987 no 928 0.283291820337626 1336 241186
SGTC_2738 aclarubicin 5.55 µM 0.57188321579991 0.278523078107306 no 929 0.283700547807055 1354 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2080 5212524 12.4 µM 0.569178580526257 0.279400075204787 no 930 0.284617477552991 1396 260183
SGTC_253 dyclonine 31.25 µM 0.56873161250084 0.27954513679567 no 931 0.284769145499807 1433 3180 An oral anasthetic.
SGTC_2167 5876490 200 µM 0.567152034626927 0.280058074900101 no 932 0.285305446387287 1572 686534
SGTC_1886 st057356 49.9 µM 0.567016907295542 0.280101976124628 no 933 0.285351347373228 1313 24207747
SGTC_468 gf-109203x 121 µM 0.565885590847995 0.280469657855817 no 934 0.285735778693935 1338 2396 A protein kinase C inhibitor.
SGTC_913 3487-1245 167 µM 0.565203643495413 0.280691405890049 no 935 0.285967629376736 1328 4016153
SGTC_1964 st076914 61 µM 0.564477517011469 0.280927612785157 no 936 0.286214598477639 1387 24208661
SGTC_294 k038-0071 157 µM 0.564360140700644 0.280965803985995 no 937 0.286254529848996 1380 24152826
SGTC_2255 7941087 197.44 µM 0.562623165630995 0.281531263639002 no 938 0.286845757046818 1477 935561
SGTC_629 3448-6466 76.7 µM 0.559281835505246 0.282620550625822 no 939 0.28798469506245 1384 573744
SGTC_2682 pyrogallin 40.03 µM 0.558136548053981 0.282994384544049 no 940 0.288375572629161 1412 822798 An ATP competetive kinase inhibitor.
SGTC_2961 9083290 32.55 µM 0.55640893611009 0.283558744030937 no 941 0.288965665705614 1435 17741490
SGTC_2334 9017922 200 µM 0.55492668765188 0.284043379983978 no 942 0.289472403392764 1513 3163164
SGTC_2299 7976368 114.88 µM 0.553972532821747 0.284355559935959 no 943 0.289798821863056 1492 2979718
SGTC_1902 st060212 70.5 µM 0.553137724615422 0.284628826526696 no 944 0.290084553149661 1404 688944
SGTC_14 0354-0009 295 µM 0.550782761435305 0.285400376520431 no 945 0.290891301368201 1453 1713507
SGTC_1013 4112-3890 241 µM 0.548978858666874 0.285992056993636 no 946 0.291509979230548 1364 705171
SGTC_2595 hexamethylquercetagetin 100 µM 0.547348364388404 0.28652736055975 no 947 0.292069711289441 1419 386331
SGTC_3167 9103034 49.47 µM 0.546752494631135 0.286723107625643 no 948 0.292274392047043 1421 5127859
SGTC_149 3970-0822 46.1 µM 0.545165769419274 0.287244666080948 no 949 0.292819755938361 1464 3114250 YBL034C STU1
SGTC_3331 9141060 1.957 µM 0.545091928226436 0.287268948698241 no 950 0.292845146956125 1370 4906567 YPR165W RHO1
SGTC_1356 1502-0781 85.8 µM 0.544336296816757 0.287517493299746 no 951 0.293105036945016 1397 567702
SGTC_2999 9069765 71.4286 µM 0.543741859441682 0.287713088892256 no 952 0.293309561402995 1461 2097066
SGTC_2674 ligustilide 100 µM 0.54285080931373 0.288006400606177 no 953 0.293616263428785 1399 5319022 A signalling regulator.
SGTC_1269 0831-0796 3.05 µM 0.54283948858417 0.288010128018858 no 954 0.293620161011555 1471 927758
SGTC_2479 5617353 43.85 µM 0.540815282998924 0.288676974634252 no 955 0.294317453866327 1486 2731746
SGTC_1581 himbacine 57.9 µM 0.540736543158622 0.288702929075288 no 956 0.294344593398857 1389 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_716 1683-5115 658 µM 0.54057060037648 0.288757631186022 no 957 0.294401793254045 1430 723597
SGTC_529 4076-0302 30.3 µM 0.54043813245886 0.288801301997133 no 958 0.294447458131937 1406 5816522
SGTC_1898 st060199 18.6 µM 0.540289085901118 0.288850442019568 no 959 0.294498841974514 1411 688866
SGTC_1464 k208-0027 110 µM 0.540278646564856 0.288853883972243 no 960 0.294502441093692 1507 X1464
SGTC_2873 9040596 71.43 µM 0.538860487241419 0.289321644500954 no 961 0.294991561557926 1409 6463863
SGTC_2934 9036370 36.88 µM 0.538822024658623 0.289334335816212 no 962 0.295004832441235 1516 6462800
SGTC_2359 9039622 200 µM 0.53792259007021 0.289631192522257 no 963 0.295315245979529 1415 6463596
SGTC_3217 9129673 49.47 µM 0.537237859439028 0.289857282398179 no 964 0.29555166145008 1420 17248312
SGTC_197 4544-0043 41.561 µM 0.537019003626314 0.289929563427839 no 965 0.2956272436733 1423 896523
SGTC_2655 perillic acid 100 µM 0.536588502190715 0.290071768853991 no 966 0.295775943990306 1392 5702197 An apoptosis inducer.
SGTC_2697 mebhydrolin 72.4 µM 0.536420194617645 0.290127373956217 no 967 0.295834088770223 1523 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_873 0591-4978 488 µM 0.534085195857544 0.290899320793367 no 968 0.296641295833966 1580 3305145
SGTC_2859 9028643 45.46 µM 0.533605827599796 0.291057917857474 no 969 0.296807137755064 1403 17151580
SGTC_2027 5150920 200 µM 0.532729685057783 0.291347890425157 no 970 0.297110357057036 1459 786715
SGTC_565 1418-0001 44.5 µM 0.532438534210642 0.291444281016433 no 971 0.29721115118053 1478 2862145
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.531364001637526 0.291800152561681 no 972 0.297583281079159 1420 688664
SGTC_1049 3226-0134 66 µM 0.529949019148702 0.292269085390426 no 973 0.298073639049189 1448 5702385
SGTC_2795 7780010 54.55 µM 0.529902799954748 0.292284408590783 no 974 0.298089662380985 1436 953673
SGTC_1116 jasmonic acid 1.58368 µM 0.52921563478743 0.292512270766769 no 975 0.298327935994946 1488 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1026 k007-1105 30.6 µM 0.525223716974023 0.293837610253837 no 976 0.299713839759584 1433 7066794
SGTC_361 000s-0510 1.45 µM 0.524979351272627 0.293918831211664 no 977 0.299798772659661 1444 660
SGTC_1 0258-0098 57.368 µM 0.524726557762352 0.294002864283537 no 978 0.299886646235515 1407 6790032 YDR047W HEM12
SGTC_2483 5729050 27.16 µM 0.52373840093722 0.294331451759992 no 979 0.300230251326338 1567 2865180
SGTC_3286 9117135 37.221 µM 0.523419745129953 0.294437449135017 no 980 0.300341093295656 1393 3438150
SGTC_2183 6420625 130.508 µM 0.523092182834502 0.294546427519322 no 981 0.300455052589573 1430 2897619
SGTC_824 1304-0008 100 µM 0.522229798436671 0.294833427585618 no 982 0.300755170459465 1454 768245
SGTC_3124 9127567 49.47 µM 0.519648568770753 0.295693225837295 no 983 0.301654269887717 1551 17592030
SGTC_452 diindolylmethane 8 µM 0.519314538287894 0.295804574334986 no 984 0.301770708380662 1460 3071 Inhibits expression of several cancer promoting factors.
SGTC_1669 st015249 58.4 µM 0.518938650595998 0.295929898891277 no 985 0.301901761883571 1503 722793
SGTC_2813 7971799 71.43 µM 0.518305916274099 0.296140913616778 no 986 0.302122422873064 1501 2234054
SGTC_169 k015-0017 16.025 µM 0.517748819773631 0.296326760519993 no 987 0.302316765701358 1539 1840002
SGTC_1250 0485-0349 40.2 µM 0.515344736658291 0.297129373175527 no 988 0.303156071291893 1458 6842794 YDL195W SEC31
SGTC_369 0957-0393 4.5 µM 0.514243486206578 0.297497361618089 no 989 0.303540883917278 1416 6997992
SGTC_1525 8-methoxypsoralen 92.5 µM 0.512786003721885 0.297984706494804 no 990 0.304050510672749 1624 4114 Related to psoralen; DNA damaging agent.
SGTC_857 0438-0306 1.35 µM 0.510934305598228 0.298604391270541 no 991 0.304698529243256 1477 4686136
SGTC_2467 5474540 200 µM 0.510623741981629 0.298708381096111 no 992 0.304807273909531 1428 5413519
SGTC_792 4534-1957 155 µM 0.509970790079133 0.298927070667667 no 993 0.305035962971786 1481 1717904
SGTC_3288 9119690 36.221 µM 0.509073305903295 0.299227778703913 no 994 0.305350420987561 1412 17595618 YKL019W RAM2
SGTC_2366 9070441 60.58 µM 0.508901256286873 0.299285440745885 no 995 0.305410719675374 1412 6837235
SGTC_1190 1486-1332 13 µM 0.508307822413211 0.299484367441241 no 996 0.305618742531201 1432 4150046
SGTC_2096 5468907 200 µM 0.508069218043406 0.299564367597629 no 997 0.305702400819269 1556 759785
SGTC_271 rotenone 740 µM 0.507806210511551 0.299652560955909 no 998 0.305794626974891 1500 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2224 6650123 117.647 µM 0.507165575212729 0.299867432064983 no 999 0.306019323525231 1458 2908370
SGTC_680 0417-1641 114 µM 0.506819498011326 0.299983536464086 no 1000 0.306140737091708 1441 2835990
SGTC_2077 5212015 200 µM 0.505378513263613 0.300467186627461 no 1001 0.30664650369882 1373 780900
SGTC_258 haloperidol 50.781 µM 0.505169724244762 0.300537293494604 no 1002 0.306719816465268 1417 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2468 5987765 72.9 µM 0.503891303282835 0.300966720778069 no 1003 0.307168881117171 1528 26772094
SGTC_3040 9091894 49.47 µM 0.503092607274578 0.301235146646012 no 1004 0.307449582042691 1451 25236966
SGTC_1425 4048-4433 7.33 µM 0.500303276347848 0.302173430092614 no 1005 0.308430773736147 1523 23734946
SGTC_2831 7999036 19.48 µM 0.499093274902277 0.302580861536632 no 1006 0.308856837523645 1652 2988270
SGTC_2197 6588183 93.1375 µM 0.498551411643373 0.302763397406512 no 1007 0.309047721019443 1461 884136
SGTC_1221 2958-7315 257 µM 0.498161169511283 0.302894887658288 no 1008 0.309185224518412 1485 4562705
SGTC_3209 9113616 49.47 µM 0.497694689125687 0.303052099565266 no 1009 0.309349625971629 1624 16649353
SGTC_2745 rifampicin 24.3 µM 0.497012041173698 0.303282229433972 no 1010 0.309590280051777 1559 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_181 1447-1644 8.07 µM 0.496367633054014 0.303499539784749 no 1011 0.309817528364489 1501 534600
SGTC_737 1950-0117 57.9 µM 0.495303142182728 0.303858664666569 no 1012 0.310193076620423 1515 5393513
SGTC_441 propafenone 146 µM 0.495278626368979 0.303866937743859 no 1013 0.310201728039003 1445 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_123 0083-0120 66.675 µM 0.495137942140384 0.303914414818362 no 1014 0.310251376317106 1416 16001701
SGTC_956 1185-0240 191 µM 0.494692919269823 0.304064619628298 no 1015 0.310408450232643 1493 1416193
SGTC_3048 9093155 49.47 µM 0.4945393885408 0.304116447233744 no 1016 0.31046264799552 1464 25236002
SGTC_931 2812-0076 566 µM 0.494324401019 0.304189027518512 no 1017 0.310538547488506 1481 3450959
SGTC_937 3122-0005 46.7 µM 0.494259604673964 0.304210904427836 no 1018 0.310561424862173 1564 759535
SGTC_2718 lomofungin 53.02 µM 0.494259007295662 0.304211106121345 no 1019 0.310561635779432 1572 5351222 A RNA synthesis inhibitor.
SGTC_1438 4092-1045 4 µM 0.492446799649811 0.304823237788202 no 1020 0.311201761051278 1470 1351342
SGTC_638 3970-0837 4.09 µM 0.492389544927646 0.304842586338098 no 1021 0.311221994432188 1462 4118451 YLR208W SEC13
SGTC_1154 4088-0362 150 µM 0.491371685795611 0.305186650736688 no 1022 0.31158179322795 1461 6618304
SGTC_2695 st077686 51.995 µM 0.490809584811753 0.305376730178501 no 1023 0.311780565134897 1448 2876092
SGTC_758 0868-0029 16 µM 0.490722815788319 0.30540607657221 no 1024 0.311811253555979 1593 762687
SGTC_2156 5649887 115 µM 0.488986398748315 0.305993617747531 no 1025 0.312425663090393 1587 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1335 1486-0900 202 µM 0.48784171855844 0.30638120972319 no 1026 0.312830979429203 1473 X1335
SGTC_2525 harmine 47.85 µM 0.485074009867169 0.307319258740111 no 1027 0.313811923716228 1573 5280953 A monoamine oxidase inhibitor
SGTC_596 1155-0152 116 µM 0.483674573866684 0.307794045051605 no 1028 0.314308420375381 1495 280313
SGTC_502 l-744,832 89.3 µM 0.482580310492448 0.308165519920118 no 1029 0.314696881097813 1588 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2398 5228213 48.84 µM 0.482356966452466 0.30824136376778 no 1030 0.314776192891059 1633 80771 YMR134W ERG29
SGTC_1975 st070967 30.8 µM 0.480266729246363 0.308951569382685 no 1031 0.315518871664305 1590 261391
SGTC_1667 st014849 34.6 µM 0.479088680934377 0.309352153239275 no 1032 0.315937770918323 1525 5348460
SGTC_1125 tnp00248 1.32998 µM 0.477276348143486 0.309968861882814 no 1033 0.316582675410571 1666 24207736
SGTC_1840 st055363 71 µM 0.476593918128754 0.310201220962735 no 1034 0.316825657533024 1446 676033
SGTC_3068 9116768 49.47 µM 0.475406139172195 0.310605825915597 no 1035 0.317248759762375 1493 41904888
SGTC_2166 5933061 31.504 µM 0.475149942876179 0.310693126673837 no 1036 0.317340051545827 1675 2877375
SGTC_2278 7948257 134.34 µM 0.473260242556631 0.311337384894512 no 1037 0.318013761478201 1611 1247028
SGTC_863 0466-0191 129 µM 0.472979653577368 0.311433095848012 no 1038 0.318113847607963 1553 765160 YPR165W RHO1
SGTC_1200 1643-0193 18.4 µM 0.472284953256016 0.311670118042823 no 1039 0.3183617044586 1527 5403974
SGTC_1626 st003712 1.76 µM 0.471802491018784 0.311834773452483 no 1040 0.318533886358296 1559 24207035
SGTC_655 k060-0012 42 µM 0.471566561545772 0.311915305501356 no 1041 0.318618099521028 1477 5994525
SGTC_1609 st001574 46.4 µM 0.47130620319097 0.312004186529815 no 1042 0.318711043255375 1494 3960012
SGTC_3240 9133527 49.47 µM 0.47114497696032 0.31205923136292 no 1043 0.318768604138557 1505 17617455
SGTC_1689 st020265 53.493 µM 0.470873406263764 0.312151958788557 no 1044 0.318865570015552 1601 5758320 YPR016C TIF6
SGTC_338 4055-0136 114 µM 0.470762325436043 0.312189890608338 no 1045 0.318905235636799 1473 2900563
SGTC_275 trichlorophene 5.69 µM 0.470589835131216 0.312248796448665 no 1046 0.318966833951446 1564 62616
SGTC_104 0074-0074 590.992 µM 0.469625002579272 0.312578377483192 no 1047 0.319311479160706 1476 3943124
SGTC_2319 6033012 152.6 µM 0.469413211272223 0.312650744206651 no 1048 0.319387153472344 1456 847246
SGTC_2380 9035439 200 µM 0.468402677028586 0.312996131881778 no 1049 0.319748326999558 1595 6462575
SGTC_2287 7945887 168.79 µM 0.463162831523267 0.314789671391796 no 1050 0.321623827951452 1575 1245853
SGTC_1321 1326-2144 215 µM 0.461537528245224 0.315346885757865 no 1051 0.322206501597506 1606 3513030
SGTC_595 3909-8003 73.7 µM 0.460872504264805 0.315575001925848 no 1052 0.32244503981047 1563 699517
SGTC_2983 9022671 12.99 µM 0.460808926688446 0.315596813954474 no 1053 0.322467848354851 1672 6405161
SGTC_2625 euphol 100 µM 0.459564472025968 0.31602388748053 no 1054 0.322914432665277 1668 6708538 A triterpene alcohol.
SGTC_849 0386-0493 241 µM 0.458622856795034 0.316347195473388 no 1055 0.32325251000082 1507 726119
SGTC_1288 0973-0013 65.5 µM 0.458512977732815 0.316384932117366 no 1056 0.32329197047533 1581 4315430
SGTC_1285 0929-0069 65.5 µM 0.458098023899862 0.316527460268503 no 1057 0.323441009288521 1558 1206237
SGTC_675 1309-0189 238 µM 0.457941564104627 0.316581208082415 no 1058 0.323497212251505 1502 4246530
SGTC_1614 st002383 48.6 µM 0.45761494899764 0.316693420940558 no 1059 0.323614550811574 1540 1947235
SGTC_3183 9108214 49.47 µM 0.455912413480155 0.317278622085067 no 1060 0.32422648132795 1517 4974831
SGTC_2381 9035592 200 µM 0.45540925684644 0.317451656325282 no 1061 0.32440741845033 1463 4749657
SGTC_1917 st066507 28.5 µM 0.45236650773202 0.318498898781286 no 1062 0.32550248537124 1531 3156428
SGTC_576 1073-0113 22.7 µM 0.450009368327023 0.31931116907675 no 1063 0.326351842760554 1628 5439563
SGTC_2667 digitoxin 100 µM 0.44999052666901 0.31931766541444 no 1064 0.326358635686446 1580 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2693 st077581 40.7 µM 0.449630208585056 0.319441908674303 no 1065 0.326488551153685 1569 25238761
SGTC_1966 st070145 16.1 µM 0.448823154154555 0.319720267093689 no 1066 0.326779617214191 1510 3748532
SGTC_2326 6164455 177.58 µM 0.447008856770389 0.320346400936254 no 1067 0.327434332549622 1552 2888790
SGTC_2788 5282734 71.43 µM 0.445890718555871 0.320732537674268 no 1068 0.327838093498159 1691 743706
SGTC_780 0109-0199 192 µM 0.443700229358151 0.321489561182294 no 1069 0.328629664812431 1688 610414
SGTC_910 3454-3003 490 µM 0.442462950312821 0.321917487569033 no 1070 0.329077117451297 1573 820824
SGTC_3216 9129716 49.47 µM 0.442434497451065 0.321927331081336 no 1071 0.329087410098481 1484 8056934
SGTC_1259 0671-0132 43 µM 0.442050630721779 0.322060145290943 no 1072 0.329226284182513 1545 X1259
SGTC_66 0109-0187 42.4 µM 0.441688244846035 0.322185548188157 no 1073 0.329357408618001 1505 759417
SGTC_2221 6807166 181.081 µM 0.441100714237904 0.322388904975816 no 1074 0.329570043229893 1615 674925
SGTC_2136 5328288 199.296 µM 0.440663406282659 0.322540301035172 no 1075 0.329728346181891 1538 262395
SGTC_378 3970-0959 8.33 µM 0.440074044748762 0.322744384615126 no 1076 0.329941739911026 1584 6615653
SGTC_426 0988-0037 14.6 µM 0.437618292304382 0.323595334625607 no 1077 0.33083150436747 1606 5383008
SGTC_880 0833-0487 87.2 µM 0.436508914776085 0.323980051328681 no 1078 0.331233766312203 1548 76075
SGTC_129 0088-0017 176.636 µM 0.435136586927986 0.324456215769504 no 1079 0.331731643982179 1657 182446
SGTC_3173 9105693 49.47 µM 0.434411323086943 0.324707980743181 no 1080 0.331994888351154 1632 17096658
SGTC_2461 5755302 26.15 µM 0.434372404802538 0.32472149293485 no 1081 0.332009016617518 1682 2788904
SGTC_599 1935-0052 86.5 µM 0.433828675975424 0.324910296393161 no 1082 0.332206428132831 1553 9557311
SGTC_765 1319-0117 244 µM 0.433477866621214 0.325032134703125 no 1083 0.332333821134323 1513 3487746 YGL099W LSG1
SGTC_139 0099-0334 718.624 µM 0.433178617283652 0.32513608068346 no 1084 0.332442505930189 1611 97690
SGTC_2328 6201408 200 µM 0.432850933006736 0.325249919314973 no 1085 0.332561534213512 1554 2890418
SGTC_2996 9066192 71.4286 µM 0.430281431071646 0.32614313770059 no 1086 0.333495466481818 1498 6472854
SGTC_3091 9116372 49.47 µM 0.42698753323854 0.327289632735877 no 1087 0.334694204022238 1584 17169793
SGTC_1373 2887-0003 58.5 µM 0.42695667927226 0.327300379691533 no 1088 0.334705440598395 1574 776948
SGTC_1303 1160-0052 261 µM 0.425255316609252 0.327893214314964 no 1089 0.335325281591728 1597 3562476
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.425194752844493 0.327914325581127 no 1090 0.335347354479871 1552 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_590 k048-0076 22.4 µM 0.424821774115624 0.328044350311606 no 1091 0.33548330171601 1661 6832814
SGTC_226 1,3-diallylurea 8.28947 mM 0.423048481152157 0.328662825778337 no 1092 0.336129944733316 1608 74537 YKL182W FAS1
SGTC_2560 caryophyllene 100 µM 0.422816620670954 0.328743727043009 no 1093 0.336214530102476 1594 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_998 3996-0085 177 µM 0.422483013598933 0.328860144031449 no 1094 0.336336248346478 1731 715391
SGTC_829 1635-0120 117 µM 0.422327575631078 0.328914392018996 no 1095 0.336392966542741 1695 285054
SGTC_605 1315-0399 119 µM 0.421323331071131 0.329264961074372 no 1096 0.336759497847052 1638 24020461
SGTC_1376 2910-0861 41.3 µM 0.421056323907124 0.329358195176593 no 1097 0.336856976803021 1619 1112859
SGTC_2705 st078069 42.8 µM 0.420049885259798 0.329709720800117 no 1098 0.337224505815821 1570 1530061
SGTC_1627 st003713 25.6 µM 0.419680131939473 0.329838904855284 no 1099 0.337359570557416 1585 16195070 YER133W GLC7
SGTC_3021 9087658 49.47 µM 0.419570946642586 0.329877055790852 no 1100 0.337399458140722 1610 25237042
SGTC_3139 9095020 49.47 µM 0.418111847168569 0.330387056146438 no 1101 0.337932671723232 1501 25236292
SGTC_1610 st001799 48.1 µM 0.417048511543813 0.330758923426119 no 1102 0.338321462319933 1536 621897
SGTC_2863 9028737 58.44 µM 0.416433958812774 0.330973919604371 no 1103 0.33854624173905 1706 6460917
SGTC_1822 st052468 42 µM 0.416375403120731 0.330994407738049 no 1104 0.338567662130496 1569 2873678
SGTC_1343 1487-0095 224 µM 0.415981443629657 0.33113226393486 no 1105 0.338711790925688 1688 4560101 YGL055W OLE1
SGTC_654 1124-0271 80.9 µM 0.41571791843834 0.331224490714952 no 1106 0.338808213943965 1560 5403748
SGTC_227 fluconazole 33.516 µM 0.414201144268369 0.331755520086412 no 1107 0.339363401937331 1570 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_648 0375-0473 33.3 µM 0.413370418580711 0.332046504267012 no 1108 0.339667622127134 1629 1713139
SGTC_439 amiodarone 34.4 µM 0.413079111360481 0.332148566515615 no 1109 0.339774326544846 1679 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2421 5690543 90.72 µM 0.413032972833943 0.332164732728642 no 1110 0.339791228040824 1631 3397993
SGTC_122 0236-0016 402.397 µM 0.412949240857989 0.332194071892018 no 1111 0.339821901617042 1634 6808838
SGTC_2079 5212404 121 µM 0.411451353408602 0.332719095964811 no 1112 0.340370802494455 1716 758462
SGTC_3310 9130229 44.1445 µM 0.411105699952497 0.332840297500336 no 1113 0.340497515299819 1679 7761258
SGTC_2763 lisinopril 49.32 µM 0.410993921058258 0.332879495910348 no 1114 0.340538496083023 1626 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1967 st070177 51.4 µM 0.410873009790261 0.332921898900276 no 1115 0.340582827129901 1662 5729214
SGTC_2204 7233102 200 µM 0.407718543817755 0.334028908327257 no 1116 0.341740160827631 1650 2172480
SGTC_2716 st080858 38.6235 µM 0.406673964757564 0.334395805759428 no 1117 0.342123732427375 1682 5296050
SGTC_1402 3909-7673 35.9 µM 0.404201869360333 0.335264733206547 no 1118 0.34303213960416 1587 5328014
SGTC_2190 6049624 200 µM 0.403984684598719 0.33534111463381 no 1119 0.343111990748381 1665 2265554
SGTC_2514 salinomycin 42.74 µM 0.403038845549017 0.335673834882991 no 1120 0.343459823922512 1779 23682228 A polyether potassium ionophore.
SGTC_1960 st011366 51.8 µM 0.402950603797045 0.335704882488578 no 1121 0.343492281675052 1607 3972846
SGTC_634 1611-4317 11.2 µM 0.4028534724382 0.335739059173401 no 1122 0.343528010604795 1693 2843522
SGTC_1388 3346-4487 254 µM 0.402008333932081 0.336036487313815 no 1123 0.343838946464628 1675 3345614
SGTC_2491 paeonol 100 µM 0.401253584151426 0.336302191921312 no 1124 0.344116716625206 1601 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3102 9121669 49.47 µM 0.396510795092596 0.337973726225057 no 1125 0.345864122882454 1668 41905072
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.396441640221723 0.337998122706252 no 1126 0.345889626320436 1701 140250 A respiratory chain inhibitor.
SGTC_545 4218-0007 221 µM 0.393326217004953 0.339097887311235 no 1127 0.347039278534461 1647 2840508
SGTC_930 2810-3379 265 µM 0.391402982552612 0.339777487357237 no 1128 0.347749694030868 1769 1015764
SGTC_2212 7123476 200 µM 0.38953043847569 0.340439676088723 no 1129 0.348441899250041 1704 1085715
SGTC_2298 7976326 193.81 µM 0.388839456188548 0.340684152955082 no 1130 0.348697455662603 1648 2235818
SGTC_1346 1488-2224 62.4 µM 0.388783977145578 0.340703784933694 no 1131 0.34871797729434 1738 3722427
SGTC_403 arphamenine a 50 µM 0.388516631556637 0.340798394685256 no 1132 0.348816874313358 1687 5487158 An arginine aminopeptidase inhibitor.
SGTC_2260 7964312 200 µM 0.385617592620841 0.341824964800431 no 1133 0.349889951047849 1752 231951
SGTC_2424 5537928 59.2 µM 0.385295795603953 0.341938987715602 no 1134 0.35000913808453 1598 5382802
SGTC_721 1187-1332 279 µM 0.385265350061669 0.341949776286041 no 1135 0.35002041525642 1610 25730
SGTC_517 1365-0151 113 µM 0.384620253800961 0.342178400550011 no 1136 0.350259393022515 1666 768657
SGTC_1045 1348-1485 165 µM 0.384450754533453 0.342238481257637 no 1137 0.350322194355186 1622 6810614
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.383847684481322 0.342452277830922 no 1138 0.3505456715797 1659 97141
SGTC_2536 dehydroabietamide 32.04 µM 0.382618580445089 0.34288816826546 no 1139 0.351001295782599 1768 3983547
SGTC_1377 2944-0135 198 µM 0.380755267642123 0.343549373853834 no 1140 0.351692427309538 1691 1894137
SGTC_967 1306-0166 352 µM 0.380710212196864 0.343565367936393 no 1141 0.351709145152758 1786 4437607
SGTC_3017 9080681 49.47 µM 0.380175568958017 0.343755180533898 no 1142 0.351907546649978 1633 16451914
SGTC_2935 9038016 29.96 µM 0.379547109963012 0.343978350592797 no 1143 0.352140813929229 1718 6463195
SGTC_1042 0350-0096 82 µM 0.378529110224131 0.344339964540843 no 1144 0.352518786423304 1609 3122515
SGTC_501 nsc-95397 161 µM 0.377097383808067 0.344848783336371 no 1145 0.353050617677572 1741 262093
SGTC_1776 st049249 45.9 µM 0.376348191726502 0.345115149373522 no 1146 0.353329028226399 1604 1822314
SGTC_415 dibenzyl ketone 100 µM 0.375825720721086 0.34530095295682 no 1147 0.353523232439055 1769 7593
SGTC_812 4251-0442 148 µM 0.375814920399857 0.34530479421113 no 1148 0.353527247356908 1746 5723007
SGTC_1041 0206-0046 107 µM 0.374462373564327 0.345785968367234 no 1149 0.354030172600541 1663 50494
SGTC_1393 3470-5649 58.2 µM 0.372600004221429 0.346448921690836 no 1150 0.354723084848072 1649 4108395
SGTC_817 1391-0715 46 µM 0.371377945560587 0.346884197542348 no 1151 0.355178024900335 1629 1353946
SGTC_1799 st045822 46.1415 µM 0.370939132320611 0.347040544474505 no 1152 0.355341433862749 1783 3674992
SGTC_2699 st077704 54.6 µM 0.37018895231663 0.347307890109606 no 1153 0.355620853792518 1665 645852
SGTC_127 0180-0333 59.125 µM 0.365736902046294 0.34889605065773 no 1154 0.357280703598315 1695 771601
SGTC_1926 methyl fluorone black 53.6 µM 0.364229605536719 0.349434344082813 no 1155 0.357843280551904 1638 72721 Reacts with homocysteine.
SGTC_3267 9137951 49.47 µM 0.360131787413514 0.350899306511372 no 1156 0.359374291239494 1726 16643986
SGTC_1481 3346-2004 36 µM 0.359668793052264 0.351064966077838 no 1157 0.359547415953477 1698 2770522
SGTC_331 k048-0133 24.5 µM 0.359459122061677 0.351139995756207 no 1158 0.359625826460463 1656 6813582
SGTC_2670 beta-carotene 100 µM 0.358786500590546 0.351380729022328 no 1159 0.359877406094299 1719 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_42 0133-0086 60.653 µM 0.358624701899104 0.351438646166145 no 1160 0.359937932487959 1581 162923 Model of phenazepam hydroxylation.
SGTC_2162 5663267 200 µM 0.358018881734016 0.351655534998193 no 1161 0.360164591646522 1787 6456493
SGTC_996 3970-0799 1.8 µM 0.357944809144461 0.351682056937489 no 1162 0.3601923082467 1806 6615648 YGL040C HEM2
SGTC_947 3447-0010 211 µM 0.357603658943023 0.351804216229043 no 1163 0.36031996985972 1667 748350
SGTC_1563 conessine 56.1 µM 0.355448580414776 0.352576261357164 no 1164 0.36112677994211 1771 441082 An anti-amoebic, histamine inhibitor.
SGTC_535 2293-4129 48.2 µM 0.355330514491325 0.352618575416245 no 1165 0.361170998905933 1806 396118 YIL048W NEO1
SGTC_2947 9072639 7.68 µM 0.355212108025031 0.3526610133552 no 1166 0.361215347275664 1627 16488146
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.35512413250595 0.352692545757263 no 1167 0.361248299140432 1651 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2773 thioridazine 9.09 µM 0.354354879147846 0.352968306532752 no 1168 0.361536472362938 1722 5452 An antipsychotic.
SGTC_2819 7996655 46.38 µM 0.351847128892703 0.353867816758061 no 1169 0.362476455932026 1778 6456960
SGTC_2493 resveratrol 26.09 µM 0.351599358482609 0.353956734441113 no 1170 0.36256937318983 1664 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2842 9000675 19.48 µM 0.351341196494577 0.354049389836743 no 1171 0.362666196041256 1603 2989072
SGTC_339 3091-4833 71.4 µM 0.348101721857607 0.355212783616999 no 1172 0.363881895626101 1738 3240077
SGTC_492 tmb-8 126 µM 0.345727417817112 0.356066326928946 no 1173 0.364773788508826 1794 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1231 0242-0792 125 µM 0.34459959048737 0.356472024980263 no 1174 0.365197706848545 1673 3707635
SGTC_2126 5251174 33.877 µM 0.343947122374735 0.356706802712749 no 1175 0.365443026398851 1892 790722
SGTC_1732 st034308 51.822 µM 0.342318259392605 0.357293153612466 no 1176 0.366055697860668 1669 830119
SGTC_2822 7994718 71.43 µM 0.340491086759258 0.357951292304723 no 1177 0.366743366993366 1742 1018011
SGTC_17 0960-0276 49.807 µM 0.337264256553642 0.359114611589023 no 1178 0.367958850978911 1735 6821114
SGTC_3305 9127027 53.8275 µM 0.335323922682484 0.359814760477162 no 1179 0.368690374815691 1740 41905295
SGTC_518 1021-0119 62.6 µM 0.33501615627498 0.359925858029489 no 1180 0.368806449412881 1660 1097762
SGTC_132 0417-1715 25.805 µM 0.334755645497336 0.360019906488072 no 1181 0.368904710826606 1868 6769098
SGTC_1238 0333-0287 48.8 µM 0.333616121112007 0.360431392121428 no 1182 0.369334625848182 1712 7226
SGTC_867 0518-0118 155 µM 0.333050699855741 0.360635627466017 no 1183 0.369548006338864 1762 6848158
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.331332414752691 0.36125653159877 no 1184 0.370196704665925 1773 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1772 st048439 82.2 µM 0.331167172430992 0.361316261384919 no 1185 0.370259107535794 1727 2927068 YDL195W SEC31
SGTC_3002 9075603 71.4286 µM 0.328131120511144 0.362414296856127 no 1186 0.371406262353641 1745 20105405
SGTC_1892 st058411 7.36 µM 0.326129812139398 0.36313872130943 no 1187 0.372163071102725 1838 3934738
SGTC_1372 2752-0194 270 µM 0.324221583076104 0.363829909674058 no 1188 0.372885141482387 1695 823334
SGTC_3194 9111903 49.47 µM 0.324198710147339 0.363838197275289 no 1189 0.372893799271736 1793 17087251
SGTC_2605 digitonin 300 nM 0.323672541291485 0.364028862834662 no 1190 0.373092980776171 1886 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2451 5856223 45.7 µM 0.32314279625618 0.364220858288084 no 1191 0.373293550316576 1704 2179896
SGTC_1484 3473-2379 286 µM 0.322231690001545 0.364551150147727 no 1192 0.373638589309286 1779 671917
SGTC_477 mead ethanolamide 10 µM 0.321907872051381 0.364668564024575 no 1193 0.373761244668707 1741 16061185
SGTC_1105 epirubicin 18.1 µM 0.320404654580664 0.365213785121202 no 1194 0.374330798772134 1698 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3003 9075612 71.4286 µM 0.31978057511659 0.365440220584422 no 1195 0.374567336924977 1756 6501993
SGTC_955 1216-0110 33 µM 0.319679267730953 0.365476982486002 no 1196 0.37460573883399 1684 3619719
SGTC_536 3852-0578 10.6 µM 0.31626485876413 0.366716706344491 no 1197 0.375900740940693 1863 2869208
SGTC_404 fumagillin 50 µM 0.315952136168459 0.366830321279077 no 1198 0.376019419148446 1778 12015870 A methionine aminopeptidase binder.
SGTC_3215 9129942 49.47 µM 0.315948894203343 0.36683149917531 no 1199 0.37602064953546 1904 17682944
SGTC_419 nsc-638432 893 µM 0.315912524782264 0.366844713285009 no 1200 0.376034452504288 1745 368090
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.315721144240249 0.366914250218459 no 1201 0.376107088102956 1719 6708760
SGTC_2899 9053889 58.44 µM 0.313350403785627 0.367776005514291 no 1202 0.377007230070552 1903 6470052
SGTC_1859 st055998 20 µM 0.311388888502201 0.368489512741958 no 1203 0.377752500005489 1914 676301
SGTC_2124 5246320 200 µM 0.311383259096225 0.368491561109786 no 1204 0.377754639532431 1788 579342
SGTC_1802 st050112 57.9 µM 0.309269089288566 0.369261106311681 no 1205 0.378558421155985 1780 4662563
SGTC_2446 5162541 200 µM 0.308887938028532 0.369399898958394 no 1206 0.3787033862528 1729 1549321
SGTC_3014 9081533 49.47 µM 0.307416870454659 0.369935733871081 no 1207 0.379263044368708 1882 21367265
SGTC_1403 3909-7815 62.9 µM 0.304380951326266 0.371042361969792 no 1208 0.380418839194874 1783 6615483
SGTC_387 norethindrone acetate 66.7 µM 0.303936107606163 0.371204602585848 no 1209 0.380588284176761 1736 541197
SGTC_1284 0929-0043 16 µM 0.303837573564284 0.371240542402404 no 1210 0.380625819781859 1774 1239883
SGTC_854 0422-0053 192 µM 0.303794901752079 0.371256107088552 no 1211 0.380642075551168 1730 3596728
SGTC_1757 st041620 31.8375 µM 0.303522626295006 0.371355425428862 no 1212 0.380745803480296 1738 5289815
SGTC_3195 9113082 49.47 µM 0.302533340451243 0.371716360823364 no 1213 0.381122760721812 1924 17018038
SGTC_3252 9135871 49.47 µM 0.302532149536329 0.37171679539003 no 1214 0.381123214575813 1833 17682838
SGTC_803 4488-1585 147 µM 0.301985685383283 0.371916218230177 no 1215 0.381331487621954 1861 747204
SGTC_1002 4049-0206 172 µM 0.300538742899312 0.372444421239131 no 1216 0.381883124446951 1744 4662749
SGTC_2382 9035899 200 µM 0.300354711762583 0.37251161860557 no 1217 0.381953302267336 1756 6462679
SGTC_2293 7624732 200 µM 0.299675401952007 0.372759696254071 no 1218 0.382212381577172 1713 894453
SGTC_801 0866-0028 10.1 µM 0.299327095753506 0.372886914927622 no 1219 0.382345241177872 1795 6849771
SGTC_1422 4031-0024 15.5 µM 0.299167484648033 0.372945217441234 no 1220 0.382406128639032 1881 782427
SGTC_86 0417-1630 471.922 µM 0.295632943209309 0.374237053165532 no 1221 0.383755206265527 1867 3634867
SGTC_879 0831-1030 162 µM 0.295532273443409 0.374273867618183 no 1222 0.383793651026941 1755 1549252
SGTC_3277 9138724 49.47 µM 0.294745881140947 0.37456148696019 no 1223 0.384094005599794 1825 15943418
SGTC_2269 7935389 174.42 µM 0.294451519016612 0.374669166507763 no 1224 0.384206452149079 1721 97605
SGTC_2056 5235370 200 µM 0.294309442422807 0.374721142531918 no 1225 0.384260729001067 1760 5511916
SGTC_681 1642-0006 26.6 µM 0.293843781970923 0.374891511516008 no 1226 0.384438638974681 1784 4446530
SGTC_645 0845-0943 5.41 µM 0.29234363287593 0.375440529846181 no 1227 0.385011950474801 1803 1885106
SGTC_1948 st076329 66.6 µM 0.292087162091089 0.375534417249313 no 1228 0.385109991038066 1841 24208413
SGTC_916 4466-0038 42 nM 0.292050848313331 0.375547711391655 no 1229 0.38512387322547 1961 5722064 YGL116W CDC20
SGTC_669 0108-0021 26.2 µM 0.291984251416591 0.375572092291236 no 1230 0.385149332556638 2029 17201
SGTC_667 1498-1044 59 µM 0.290539901956562 0.376100985862822 no 1231 0.385701614612805 1804 6739982
SGTC_555 4296-0685 37 µM 0.290416466184007 0.376146196529228 no 1232 0.385748824041778 1823 2908540 YHR072W ERG7
SGTC_2852 9023854 51.95 µM 0.29032635900522 0.376179201046493 no 1233 0.385783287635936 1853 19798528
SGTC_987 1497-1013 404 µM 0.289718224033332 0.376401972795665 no 1234 0.386015906616492 1830 1676435
SGTC_2903 5923464 63.88 µM 0.287520485019031 0.377207390434873 no 1235 0.386856909515035 1922 2876576
SGTC_1564 D-Arginine 115 µM 0.284830773135138 0.378193831179158 no 1236 0.387886897385806 1705 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2337 9009472 200 µM 0.283249782302288 0.378774024241848 no 1237 0.38849268470754 1897 5742383
SGTC_2644 guaiazulene 100 µM 0.282749912751146 0.378957523628758 no 1238 0.388684275951908 1907 3515 A coloring agent.
SGTC_2373 9071805 200 µM 0.282295712548688 0.379124281706829 no 1239 0.388858386418713 1975 10149009
SGTC_43 0570-0105 72.5 µM 0.281262258462191 0.379503794686801 no 1240 0.389254627842045 1800 1114046 YDL195W SEC31
SGTC_710 3448-4187 58 µM 0.279400301804119 0.380187849638617 no 1241 0.389968819747138 1801 3946412
SGTC_156 3474-0145 5.642 µM 0.277994906385974 0.380704419268921 no 1242 0.390508134410827 1954 2265471
SGTC_2473 5854593 8.94 µM 0.277618139449383 0.380842940592291 no 1243 0.39065275302356 1797 2872951
SGTC_391 gliotoxin 8.33 µM 0.276685929115194 0.381185740658761 no 1244 0.391010638586246 1862 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1873 rapamycin 2 nM 0.276576544877414 0.381225970450263 no 1245 0.391052638427832 1785 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1526 st051518 75 µM 0.27627447812608 0.381337072486143 no 1246 0.391168628424926 1792 673993
SGTC_2651 TUB2.036 5 µM 0.274548106449011 0.381972230173403 no 1247 0.391831719832725 1927 15992207 YFL037W TUB2
SGTC_2786 7743617 45.45 µM 0.273300469873626 0.382431452079998 no 1248 0.392311127085086 1736 583674
SGTC_370 0180-0345 38.7 µM 0.272568455150992 0.382700964298644 no 1249 0.392592481591361 1788 3989527
SGTC_2989 9073649 71.4286 µM 0.271160210511686 0.383219609639367 no 1250 0.393133907133315 1984 21367202
SGTC_994 3910-0338 138 µM 0.270201853094069 0.383572684875108 no 1251 0.393502483569942 1907 3479481
SGTC_1488 4013-0813 75.9 µM 0.269352667366599 0.383885620211012 no 1252 0.393829153239842 1813 2910057
SGTC_157 1348-1695 65.819 µM 0.268373041620514 0.384246718355366 no 1253 0.394206094142925 1810 5380510
SGTC_1193 1488-0126 41.5 µM 0.267290193601632 0.384645982003764 no 1254 0.394622868280044 1808 1384710
SGTC_3159 9100096 49.47 µM 0.266026500735188 0.385112080809831 no 1255 0.3951093997703 1837 25236875
SGTC_2288 7946289 167.31 µM 0.265835628297633 0.385182496397165 no 1256 0.395182901367645 1932 1246052
SGTC_543 3844-1095 191 µM 0.265416282155313 0.38533721251314 no 1257 0.395344397239351 1902 4230703
SGTC_950 1165-0508 94.1 µM 0.264339950545601 0.385734404328416 no 1258 0.395758989318226 1790 6148369
SGTC_1326 1431-2094 10.8 µM 0.263608640438803 0.386004343451585 no 1259 0.396040749932315 1777 616278
SGTC_1945 st075991 56.6 µM 0.26288039050648 0.386273207868854 no 1260 0.396321385498938 1789 1084980
SGTC_1839 st053978 48 µM 0.261916984991566 0.386628973868243 no 1261 0.396692722241835 1957 3788398
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.261338516371874 0.386842636338507 no 1262 0.396915733267959 1809 6708784 An antioxidant flavonoid
SGTC_229 benomyl 22.8748 µM 0.260106312009174 0.387297876124442 no 1263 0.397390884591109 1836 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1188 1403-0014 4.57 µM 0.259397074418103 0.387559975377575 no 1264 0.397664443381333 1843 9614867
SGTC_1782 st039423 80.636 µM 0.25691893112179 0.388476176652 no 1265 0.398620678037039 1791 2068169
SGTC_661 1304-0007 33.6 µM 0.256917574979512 0.388476678205573 no 1266 0.398621201495334 1835 3117130
SGTC_2244 6635614 200 µM 0.256715701051537 0.388551341022006 no 1267 0.398699124985972 1844 836499
SGTC_2884 9058502 51.95 µM 0.25662507619238 0.388584859850662 no 1268 0.398734107564503 1816 6471554
SGTC_2939 9044578 71.43 µM 0.25600370651288 0.38881470415463 no 1269 0.39897398764169 1802 2653634
SGTC_1761 st044296 37 µM 0.255780714378443 0.388897198318047 no 1270 0.399060083176746 1822 1826700
SGTC_3307 9126885 69.2785 µM 0.255352419686697 0.38905565657481 no 1271 0.399225458208646 1777 24824909
SGTC_1995 st072814 61.1 µM 0.254866883054042 0.389235315227839 no 1272 0.399412957624291 1816 5769371
SGTC_1374 2889-5571 141 µM 0.254700825912818 0.389296765260559 no 1273 0.399477089146734 1824 2853281
SGTC_678 1218-2179 85.9 µM 0.253895557562576 0.389594796902993 no 1274 0.399788123458268 1885 6820081 YOR116C RPO31
SGTC_359 0081-0058 15.9 µM 0.253712293022594 0.389662632602236 no 1275 0.399858918143598 1968 3494159
SGTC_2624 nerol 100 µM 0.253125334561614 0.389879918947598 no 1276 0.400085681039046 1916 637566 A natural product oil.
SGTC_3026 9090633 49.47 µM 0.252910864739809 0.389959322190442 no 1277 0.40016854675547 1824 25236842
SGTC_2608 thymoquinone 42.66 µM 0.252869968687699 0.389974463672609 no 1278 0.400184348466358 1946 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3320 9137005 35.139 µM 0.252719603798918 0.390030136674252 no 1279 0.400242448938835 1832 4908713
SGTC_2007 4011539 71.82 µM 0.252430930801874 0.390137024943979 no 1280 0.400353997372595 1811 45595301
SGTC_3009 9080819 71.4286 µM 0.251848505528154 0.390352707490307 no 1281 0.400579081701377 1837 17027216
SGTC_2128 5255449 168.493 µM 0.251264768609142 0.39056890962756 no 1282 0.400804706059197 1846 736008
SGTC_95 0471-0001 561.058 µM 0.249922481031396 0.391066188981992 no 1283 0.4013236487211 1769 4015405
SGTC_701 4424-0219 185 µM 0.249581207915568 0.39119264939826 no 1284 0.401455616336318 1994 2911779
SGTC_2921 7974240 10.71 µM 0.249184639022622 0.391339614384293 no 1285 0.401608980510733 1902 2979074 YDR527W RBA50
SGTC_2485 5633444 17.78 µM 0.248335810792127 0.391654234867533 no 1286 0.401937296806447 1784 5724239
SGTC_1863 st057641 20.1 µM 0.247728617616001 0.391879336161504 no 1287 0.402172194118931 2026 3921635
SGTC_2375 9072683 200 µM 0.246473576311791 0.392344725185418 no 1288 0.402657828331681 2023 16798029
SGTC_992 3909-8734 162 µM 0.24553952918852 0.392691184529676 no 1289 0.403019352433395 1830 4288319
SGTC_302 1094-0063 18.9 µM 0.244661224627822 0.393017045280203 no 1290 0.403359376960229 1864 5440289
SGTC_3214 9129694 49.47 µM 0.243495002698161 0.393449842420607 no 1291 0.403810977954394 1976 17158655
SGTC_1332 1480-0653 17.5 µM 0.242301256977759 0.393892990316845 no 1292 0.404273369931643 2013 5749438
SGTC_2986 9022445 71.43 µM 0.24082576263438 0.394440920126595 no 1293 0.404845080736389 1996 6459286
SGTC_2727 riluzole 51.77 µM 0.238401401085757 0.39534166819523 no 1294 0.405784890420866 1996 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2953 9074162 66.49 µM 0.238079565626348 0.395461285212134 no 1295 0.405909691689109 2040 16451992
SGTC_1218 1348-1416 30.7 µM 0.236450038129777 0.396067084843728 no 1296 0.406541735960682 1853 6787668
SGTC_1171 0368-0077 21.4 µM 0.236050699630287 0.396215582876901 no 1297 0.406696664468248 1865 3239779
SGTC_566 0958-0068 16.5 µM 0.235521653467827 0.396412337196051 no 1298 0.406901937219132 1948 6815365
SGTC_167 3672-0051 66.205 µM 0.234509961169197 0.396788662913262 no 1299 0.407294550442395 1868 3237971
SGTC_2002 4023503 131 µM 0.234322876621209 0.396858264504691 no 1300 0.40736716363195 2072 4736863 YCR052W RSC6
SGTC_1019 4262-0212 3.4 µM 0.233593514118406 0.397129642647445 no 1301 0.407650281723726 2023 4677213
SGTC_1064 honokiol 6.76 µM 0.23248646014126 0.397541645799339 no 1302 0.408080101197484 1898 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_893 0958-0369 48.9 µM 0.231073668518322 0.398067598802381 no 1303 0.408628785529771 2035 6819948
SGTC_1096 rimcazole 32.2 µM 0.230748659543079 0.398188619147534 no 1304 0.408755034293754 1884 18528119 A dopamine reuptake inhibitor.
SGTC_3004 9076122 71.4286 µM 0.229979936424144 0.39847489985566 no 1305 0.409053680148724 1977 44782551
SGTC_2083 5306046 65.942 µM 0.22792644941278 0.399239907935986 no 1306 0.409851710097297 1874 539837
SGTC_3116 9124943 49.47 µM 0.225747089793841 0.400052232127114 no 1307 0.410699065474992 1796 41905195 YPL160W CDC60
SGTC_858 0438-0351 2.77 µM 0.225387092146799 0.400186457677698 no 1308 0.410839076154352 1886 2799119
SGTC_3326 9140064 16.379 µM 0.223568921577108 0.400864544586524 no 1309 0.411546374270971 1848 1868434
SGTC_2684 capsaicin 100 µM 0.223175542949975 0.401011294575204 no 1310 0.411699442912692 1941 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2441 5730946 39.09 µM 0.222723982464324 0.401179766538666 no 1311 0.411875167423686 1971 1774275
SGTC_2526 patulin 37.61 µM 0.221979314762505 0.401457633518736 no 1312 0.412164993033914 1922 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_575 k072-0246 11.9 µM 0.221741677068823 0.401546316678369 no 1313 0.412257492016287 1915 6796779
SGTC_48 0382-0018 55 µM 0.221382486819131 0.401680371224841 no 1314 0.412397313819148 2024 762596
SGTC_2966 9084041 48.03 µM 0.221360013924169 0.401688758790893 no 1315 0.412406062201123 1713 17741380
SGTC_2708 st078559 56 µM 0.221296189249774 0.401712580342265 no 1316 0.412430908486609 1997 17250902
SGTC_2537 larixol 68.93 µM 0.220984494494565 0.401828920730568 no 1317 0.412552253070345 1928 6708759
SGTC_3237 9133362 49.47 µM 0.220626282523176 0.401962634461933 no 1318 0.412691717399271 2008 43845137
SGTC_3204 9114183 49.47 µM 0.220587522815228 0.401977103413708 no 1319 0.412706808557373 1842 17027248
SGTC_1201 1889-3372 45.9 µM 0.219443795396163 0.402404115854549 no 1320 0.413152178755979 1907 5392199
SGTC_760 0568-0725 82.9 µM 0.218144291741032 0.402889428937732 no 1321 0.413658344235196 2041 3916171
SGTC_219 mitoxanthrone 164.414 µM 0.218113780919588 0.402900825320624 no 1322 0.413670230134328 1991 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2200 6600604 21.907 µM 0.217636253857027 0.403079201672726 no 1323 0.413856267497346 1927 2904777
SGTC_2774 tamoxifen 10.92 µM 0.217583161770081 0.403099035036853 no 1324 0.413876952571186 1967 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2314 7727897 200 µM 0.216672070898703 0.403439425823512 no 1325 0.414231957571326 1863 900724
SGTC_948 3448-0295 75.3 µM 0.215883512864905 0.403734096445742 no 1326 0.4145392744534 1919 678569
SGTC_356 1634-0012 32.5 µM 0.215344685263439 0.40393547852446 no 1327 0.414749296478426 2082 735457
SGTC_1075 aripiprazole 15.2 µM 0.214441430875058 0.404273119008238 no 1328 0.415101417930229 1895 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1791 st048313 56.1 µM 0.214231356657622 0.404351655910485 no 1329 0.41518332229676 2051 1204976
SGTC_622 1348-1566 26.3 µM 0.21393183668255 0.404463639053647 no 1330 0.415300106417464 1982 7340407
SGTC_2776 terbinafine 19.92 µM 0.213373345183118 0.404672466169754 no 1331 0.415517884622682 2015 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1073 triclabendazole 3.09 µM 0.212833459472137 0.404874362158216 no 1332 0.415728432357467 1929 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_936 3005-4620 401 µM 0.211871132423889 0.405234297334322 no 1333 0.416103786154908 2055 777207
SGTC_489 paxilline 115 µM 0.210926071742491 0.405587852470259 no 1334 0.416472479732238 1917 105008 A toxic potassium channel blocker.
SGTC_244 nsc-207895 1.295 µM 0.210874821635312 0.405607027770417 no 1335 0.416492475880673 1910 42640
SGTC_1521 st012942 49.4 µM 0.210725511073414 0.405662893819682 no 1336 0.416550733305879 2065 24207259
SGTC_3019 9081971 49.47 µM 0.210195164789743 0.405861343745546 no 1337 0.416757676604759 2029 16451803
SGTC_148 3253-0744 288.01 µM 0.209179993371565 0.406241277507561 no 1338 0.417153864961875 2037 6893655
SGTC_1027 k015-0025 8.67 µM 0.208782537999368 0.406390051547762 no 1339 0.417309001796637 1878 3598955
SGTC_2360 9040895 200 µM 0.207112322174315 0.407015388111119 no 1340 0.41796106951716 1905 4914414
SGTC_2361 9034121 116 µM 0.207035207024161 0.407044266120358 no 1341 0.417991181447676 1927 6496917
SGTC_1851 st056236 18.9 µM 0.205844500677823 0.407490224768627 no 1342 0.418456189481266 2051 5393171
SGTC_161 4065-0411 162.148 µM 0.202799822338748 0.40863110091871 no 1343 0.41964574840208 1952 1906281 YLR208W SEC13
SGTC_2898 9056270 58.44 µM 0.202426615950644 0.408770999159398 no 1344 0.419791611280119 1961 19154699
SGTC_525 k781-2675 26.7 µM 0.200544389771773 0.409476737650387 no 1345 0.420527422517014 2089 3651118 YDL195W SEC31
SGTC_1828 st055811 49 µM 0.198990458479608 0.410059603610813 no 1346 0.421135104186384 2084 5877589
SGTC_442 cape 100 µM 0.198456631504754 0.410259883350547 no 1347 0.421343906450841 2062 5281787
SGTC_1662 st014054 52 µM 0.195652406742156 0.411312347993009 no 1348 0.422441119127783 2063 2838777
SGTC_3143 9086658 49.47 µM 0.195107345129456 0.41151699157358 no 1349 0.422654456249596 1912 25236626
SGTC_180 1486-1293 102.781 µM 0.194157499329493 0.41187366902363 no 1350 0.423026280090563 2116 4140536
SGTC_779 1360-0071 233 µM 0.193625496786053 0.412073473612021 no 1351 0.423234566222599 2108 7566
SGTC_1291 0993-0025 5.79 µM 0.193504267329916 0.412119007039319 no 1352 0.423282032184659 2040 4353356
SGTC_3115 9123671 49.47 µM 0.192434215475079 0.412520966611433 no 1353 0.423701046567342 2114 3286988
SGTC_2420 aureobasidin a 50 nM 0.1923355027736 0.412558052168381 no 1354 0.423739705162135 2070 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2970 9090938 41.86 µM 0.191405809987676 0.412907368419994 no 1355 0.424103834253574 2097 17217104
SGTC_2425 5628681 7.85 µM 0.188872230230957 0.413859667252712 no 1356 0.42509647944533 2024 5714958
SGTC_2032 5185112 25.99 µM 0.187845228013472 0.414245832142269 no 1357 0.425498989987444 2046 5718189
SGTC_2310 7668677 200 µM 0.187664061021428 0.414313961671964 no 1358 0.425570002406364 2015 2197143
SGTC_2305 7443522 69.23 µM 0.186426415196648 0.414779458744984 no 1359 0.426055189593998 2006 5415886
SGTC_2665 lovastatin 100 µM 0.186079976777661 0.414909780875627 no 1360 0.426191021945437 1983 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1726 st035556 14.5795 µM 0.185380850824061 0.415172804413306 no 1361 0.426465163465864 2052 5919439
SGTC_62 0180-0423 3.232 µM 0.185193455001486 0.415243312499727 no 1362 0.426538651227128 2020 30102 YGL099W LSG1
SGTC_951 1171-0579 82.7 µM 0.184727216977412 0.415418747411126 no 1363 0.426721498746877 2013 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2854 9024559 71.43 µM 0.184620686514552 0.41545883480287 no 1364 0.426763279685119 1927 3163529
SGTC_2843 9000894 45.46 µM 0.184571549898039 0.415477325198347 no 1365 0.426782551200408 2031 2242070
SGTC_1358 1509-0022 2.48 µM 0.184552318942025 0.41548456197026 no 1366 0.426790093681506 1993 3258434
SGTC_2352 9027995 87.8 µM 0.180726935712593 0.416924653027921 no 1367 0.428290957638499 2003 2997347
SGTC_1649 st011737 51.3 µM 0.180577979327953 0.416980751340505 no 1368 0.428349420830126 1976 1761035
SGTC_1324 1418-0026 34.4 µM 0.180003066352186 0.417197284574452 no 1369 0.42857508045966 1998 1372513
SGTC_348 k064-0012 10.7 µM 0.179848552594876 0.417255484386398 no 1370 0.428635732783718 1982 5066323
SGTC_3065 9113888 49.47 µM 0.179797536640479 0.417274700671919 no 1371 0.428655758789502 2037 16648368
SGTC_838 0109-0203 71.4 µM 0.179616642598403 0.417342839998747 no 1372 0.428726769136827 1986 759422
SGTC_2261 9010538 184.68 µM 0.178807742643735 0.417647567486055 no 1373 0.429044332757839 1932 6457250
SGTC_1590 st077108 57.8 µM 0.178128343165389 0.417903547986633 no 1374 0.429311091674036 2095 5489485
SGTC_2195 6536160 144.242 µM 0.177515970360651 0.418134304346284 no 1375 0.429551560953932 1951 3834386
SGTC_68 0986-0284 82.829 µM 0.174955117884658 0.419099597785729 no 1376 0.430557450147469 1795 423278 YIL048W NEO1
SGTC_488 nitrendipine 139 µM 0.174601920784122 0.419232771049184 no 1377 0.430696219602039 2050 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1243 0416-0003 5.65 µM 0.173708260861271 0.41956976756644 no 1378 0.431047372501638 1965 2141977
SGTC_2346 9031566 143.75 µM 0.173626824583748 0.419600479882954 no 1379 0.431079374620094 2075 4771086
SGTC_2440 5628896 157.78 µM 0.173015793329813 0.419830935610171 no 1380 0.43131950677653 1991 5522048
SGTC_1063 disulfiram 1.84 µM 0.171748043276446 0.4203091661323 no 1381 0.43181780694118 2075 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_27 0485-0001 32.618 µM 0.17166861199158 0.42033913374303 no 1382 0.431849031717679 2105 2054479
SGTC_3118 9124250 49.47 µM 0.171493982550341 0.420405019068555 no 1383 0.431917680791791 1985 1504786
SGTC_3317 9138495 8.753 µM 0.167968983766877 0.421735427812273 no 1384 0.433303839866829 2136 17020139
SGTC_1783 st039459 87.517 µM 0.167900792862124 0.421761173356348 no 1385 0.433330663185204 2118 729761
SGTC_9 0092-0002 10.449 µM 0.166861701184678 0.422153524765018 no 1386 0.433739434311326 2088 759368
SGTC_1166 k206-0078 225 µM 0.164095918182372 0.423198234387155 no 1387 0.43482781753812 2033 5404595
SGTC_2767 sibutramine 71.45 µM 0.163771996724573 0.423320623598047 no 1388 0.434955318685491 2125 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2488 5268135 45.7 µM 0.163302527580811 0.423498019105126 no 1389 0.435140121948274 2059 1270356 YLR208W SEC13
SGTC_2650 prasterone 100 µM 0.162681987730651 0.423732522589812 no 1390 0.435384414878365 2091 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1161 k007-0610 110 µM 0.161844928474025 0.424048892053617 no 1391 0.435713985805581 2137 5843850
SGTC_3080 9117754 49.47 µM 0.160982398568823 0.424374939446618 no 1392 0.436053631864503 2124 9550191
SGTC_76 0433-0009 400.328 µM 0.160060040820937 0.424723659798419 no 1393 0.4364168890424 1967 2841569
SGTC_2402 5553605 200 µM 0.159063727377145 0.425100407138021 no 1394 0.436809332841411 2080 6758546
SGTC_211 3455-0679 143.504 µM 0.157991064997334 0.425506101641448 no 1395 0.437231919694375 2020 748649
SGTC_147 4466-0538 29.23 µM 0.157691428178655 0.425619442196352 no 1396 0.437349977652032 2026 6742687 YHR072W ERG7
SGTC_248 streptozotocin 5.23457 mM 0.157191912213242 0.425808402651063 no 1397 0.437546801090861 2142 5300 DNA alkylating agent.
SGTC_1334 1486-0610 236 µM 0.156625837897387 0.426022561865673 no 1398 0.437769869083768 2077 3742339
SGTC_2692 st077426 47.7 µM 0.156245604450888 0.426166425367448 no 1399 0.437919715486919 2105 25238571
SGTC_228 caffeine 993.056 µM 0.156230518298125 0.426172133502524 no 1400 0.437925660980721 2140 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_340 k038-0059 454 µM 0.154053229379306 0.426996114117799 no 1401 0.438783882751463 2054 23733424
SGTC_2247 cerulenin 830 nM 0.153914569494373 0.427048599865952 no 1402 0.438838548099032 2112 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_730 1436-0052 41.2 µM 0.152377584028755 0.427630468210471 no 1403 0.439444567983038 2169 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2652 actinonin 100 µM 0.15171515799074 0.427881296526944 no 1404 0.439705800612341 2121 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_646 4092-0839 27.3 µM 0.151340454845184 0.428023191180204 no 1405 0.439853579214687 2107 877796
SGTC_1215 3852-0577 11.2 µM 0.150152239044128 0.428473212763446 no 1406 0.440322253159424 2119 2884876
SGTC_2110 5483698 200 µM 0.149468518594996 0.428732205367383 no 1407 0.440591974406361 2025 2848765 YHR062C RPP1
SGTC_2238 6671620 73.2395 µM 0.14929799950577 0.428796802609396 no 1408 0.440659246872878 2174 729941
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.146851007212125 0.429723998708469 no 1409 0.441624811569111 2156 551469
SGTC_1439 4092-1168 46 µM 0.14588951183353 0.430088427775781 no 1410 0.442004305673394 2123 2886240
SGTC_1703 st026983 48.3 µM 0.144330473179041 0.430679466080249 no 1411 0.442619758054142 2162 1104023
SGTC_1216 1165-0504 9.65 µM 0.143437739476384 0.431017975306978 no 1412 0.442972239662966 2167 6304004
SGTC_642 0335-0876 158 µM 0.143293601369441 0.431072634750322 no 1413 0.443029154526222 2049 6812350
SGTC_262 fenpropimorph 62.5 µM 0.143084280829198 0.431152014750805 no 1414 0.443111809639667 2133 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2327 6189656 200 µM 0.143058302605237 0.431161866588798 no 1415 0.44312206792205 2124 5349088
SGTC_1274 0865-0114 173 µM 0.142729885326993 0.431286417432496 no 1416 0.443251756638593 2064 870624
SGTC_3051 9093778 49.47 µM 0.142187710321133 0.431492049922941 no 1417 0.443465869451368 2163 17217378
SGTC_1764 st044502 93.5 µM 0.141732484266061 0.431664719342296 no 1418 0.44364565760682 2048 8407
SGTC_2770 toltrazuril 17.5 µM 0.141302597109103 0.431827789584598 no 1419 0.443815449002726 2157 68591 Kills coccidiodes.
SGTC_1405 3909-7894 12 µM 0.140762089181443 0.432032838381613 no 1420 0.44402894662553 2150 7104060
SGTC_2891 9063876 19.48 µM 0.14015960011205 0.432261422119292 no 1421 0.444266945596652 2210 6472478
SGTC_3022 9087993 49.47 µM 0.139912525735239 0.432355168446271 no 1422 0.444364552266221 2157 17173644
SGTC_3028 9087778 49.47 µM 0.139543468319362 0.432495205344111 no 1423 0.444510354586734 2111 17217395
SGTC_2475 5812728 15.03 µM 0.13930744457527 0.432584767760818 no 1424 0.444603603662404 2170 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_975 1335-0046 28.5 µM 0.138758572687098 0.432793058042376 no 1425 0.44482046570981 2005 16486740
SGTC_844 0330-0132 15.3 µM 0.137415016303961 0.433303000225521 no 1426 0.445351381173318 2160 2828079
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.136972033267156 0.433471157294422 no 1427 0.445526450474944 2070 5379071
SGTC_408 cantharidin 100 µM 0.136426439665185 0.433678282046708 no 1428 0.445742086624356 2068 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2071 5230951 39.92 µM 0.135243684856883 0.434127356004505 no 1429 0.446209604417112 2147 1799272
SGTC_1751 st044839 27.194 µM 0.134332949252176 0.434473206394215 no 1430 0.446569649810931 2197 5291326
SGTC_1681 tripelennamine 100 µM 0.134195577440416 0.434525377479642 no 1431 0.446623961486525 2197 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_953 1188-0045 9.7 µM 0.133662694103459 0.434727766768351 no 1432 0.446834653089847 2102 6144426
SGTC_2013 4024628 200 µM 0.131840409243657 0.435420000180446 no 1433 0.447555261777083 2111 5230760
SGTC_963 1269-2853 151 µM 0.131380303205626 0.435594812563902 no 1434 0.447737234680847 2046 3668223
SGTC_2572 astragaloside iv 100 µM 0.129815073153775 0.436189599067813 no 1435 0.44835636858865 2056 45006101 An anti-inflammatory agent.
SGTC_1365 1672-3266 55.4 µM 0.129307354855458 0.436382562790229 no 1436 0.448557225980918 2175 6415873
SGTC_2103 5378138 10 µM 0.128809775990635 0.436571687604505 no 1437 0.448754084927737 2161 244142
SGTC_2582 agaric acid 100 µM 0.127109622993993 0.437218008131594 no 1438 0.449426817598186 2120 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_383 2324-0395 7.37 µM 0.126624789381828 0.437402350514193 no 1439 0.449618687889475 2127 3146421
SGTC_2163 5671233 125 µM 0.123783531501796 0.438482919300822 no 1440 0.450743335739469 2172 701023
SGTC_2217 6934799 96.0675 µM 0.123646705469162 0.438534967733076 no 1441 0.450797505294476 2189 675606
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.123010271460028 0.43877708030193 no 1442 0.451049482146702 2173 6312947
SGTC_600 1495-0418 41.6 µM 0.122059830742297 0.439138690099917 no 1443 0.451425817183056 2099 5377768
SGTC_1460 k062-0059 9.15 µM 0.12167878630191 0.439283678603423 no 1444 0.451576707230117 2155 1373085
SGTC_1023 4482-3888 16 µM 0.121612920896201 0.439308741405635 no 1445 0.451602790026697 2190 3303168
SGTC_3226 9131256 49.47 µM 0.120753685444685 0.439635715992271 no 1446 0.451943067616119 2192 17178073
SGTC_210 3551-0445 56.827 µM 0.120097417721085 0.439885480724749 no 1447 0.452202988973409 2152 2865180 YOR207C RET1
SGTC_798 1287-0182 476 µM 0.119894307737019 0.439962785906651 no 1448 0.452283436858719 2197 1649755
SGTC_447 ml7 120 µM 0.119849133587054 0.439979979837893 no 1449 0.452301329720888 2214 4216 Selective myosin light chain kinase inhibitor.
SGTC_608 k048-0125 159 µM 0.11889249457703 0.440344116934537 no 1450 0.452680264022682 2179 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_664 1222-0054 14.9 µM 0.11829613014583 0.440571143905555 no 1451 0.452916511783584 2167 6813991
SGTC_3160 9100216 49.47 µM 0.117660530968982 0.440813128458869 no 1452 0.453168320603015 2216 17191039
SGTC_1219 1469-0211 33.1 µM 0.117564096520805 0.440849844799164 no 1453 0.453206527216262 2203 6822282
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.117151262997845 0.441007032301245 no 1454 0.453370093688686 2195 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_203 k066-0004 30.888 µM 0.116919281961569 0.441095363800686 no 1455 0.453462009077329 2211 6795412
SGTC_1702 st027038 51 µM 0.11686272158517 0.441116900759282 no 1456 0.453484419774339 2098 5521182
SGTC_2723 salbutamol 83.58 µM 0.116598894959332 0.441217362487829 no 1457 0.453588956723587 2171 9884233 β2-adrenoceptor agonist
SGTC_3254 9136651 49.47 µM 0.116467444147937 0.441267418649773 no 1458 0.453641043140353 2202 16454030
SGTC_1467 k284-1082 293 µM 0.115757387543028 0.441537822748082 no 1459 0.453922411610381 2227 3334705
SGTC_1390 3413-2614 145 µM 0.112478737382388 0.44278675136284 no 1460 0.455221913929786 2092 3421432
SGTC_1530 rhein 70.4 µM 0.112464349931853 0.44279223320346 no 1461 0.455227617503118 2206 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_3177 9107506 49.47 µM 0.112206183168825 0.442890600583493 no 1462 0.455329963336568 2206 8897194
SGTC_1309 pyrazolanthrone 13.4 µM 0.111274135428242 0.443245761121335 no 1463 0.455699482475774 2213 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2112 5488546 200 µM 0.111159844750331 0.443289315187958 no 1464 0.455744796739986 2179 600757
SGTC_1318 1280-3875 124 µM 0.110547306304063 0.443522753941035 no 1465 0.455987667367284 2134 373245
SGTC_2302 7771753 200 µM 0.108801867992377 0.444188048715642 no 1466 0.45667982108642 2097 2203047
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.108469821425176 0.444314630117983 no 1467 0.456811509128847 2110 689007
SGTC_1473 k844-0725 134 µM 0.108228757322792 0.444406531125451 no 1468 0.456907116943818 2217 54682906
SGTC_396 dithiazanine 1.25 µM 0.107857642470524 0.444548017296571 no 1469 0.457054308727027 2060 10578 An antihelmenthic.
SGTC_1730 st033808 45.1 µM 0.106260591327778 0.445156967573632 no 1470 0.457687799038787 2033 1045166
SGTC_106 0092-0003 11.579 µM 0.106125878730154 0.445208338977442 no 1471 0.457741239414891 2219 1072148
SGTC_881 0833-0569 170 µM 0.10607653335752 0.445227156609436 no 1472 0.457760814874656 2018 5418700
SGTC_1553 gossypol 38.6 µM 0.105134511092088 0.445586416107086 no 1473 0.458134537574337 2210 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2861 9024595 19.48 µM 0.104992870496316 0.44564043752295 no 1474 0.458190732985962 2238 16482810
SGTC_2816 7982706 58.44 µM 0.104609673557244 0.445786593059913 no 1475 0.458342769218696 2130 2981853
SGTC_1641 st009299 47.1 µM 0.104426844218931 0.445856328782404 no 1476 0.458415310266076 2223 4046054
SGTC_3355 9151058 44.0485 µM 0.104368096460157 0.445878737015513 no 1477 0.458438619860519 2240 17015728
SGTC_2188 6126565 140.678 µM 0.104273817972386 0.445914698141524 no 1478 0.458476027429891 2204 874518
SGTC_1648 st011736 69.8 µM 0.103905508069969 0.446055188733715 no 1479 0.458622167981684 2191 2855514
SGTC_907 3448-6986 75.5 µM 0.103505251040565 0.446207873130604 no 1480 0.458780991076498 2208 590582
SGTC_1434 4073-0095 163 µM 0.103406762063633 0.446245444537794 no 1481 0.458820072784298 2215 24133745
SGTC_2911 7942208 15.64 µM 0.10301081029969 0.446396496409277 no 1482 0.458977195610059 2098 1243384
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.101426944964588 0.447000803703395 no 1483 0.459605773887632 2150 115019
SGTC_508 roscovitine 141 µM 0.101043169804971 0.447147247688903 no 1484 0.459758095484034 2228 160355 A CDKinase inhibitor.
SGTC_1174 0739-0097 51.1 µM 0.100826327376617 0.447229995339268 no 1485 0.459844163555022 2132 728447
SGTC_862 0452-0056 10.2 µM 0.100484108292868 0.447360591728483 no 1486 0.4599799993618 2216 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2593 nobiletin 86.24 µM 0.0970819477621178 0.448659219870484 no 1487 0.461330658367805 2125 72344 An anti-infammatory.
SGTC_3308 9128332 17.569 µM 0.0955742997655424 0.449234876298721 no 1488 0.461929338777835 2224 17332805 YDL196W YDL196W
SGTC_1421 4029-0249 71.4 µM 0.0934044382037556 0.450063569151281 no 1489 0.462791132378863 2258 2894095
SGTC_2460 5552655 174.22 µM 0.0916533173574228 0.450732499516369 no 1490 0.463486744278277 2102 5401989
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.0915348467905478 0.450777760498037 no 1491 0.463533809356037 2252 5355888
SGTC_1578 josamycin 24.2 µM 0.0914232718260009 0.450820387640763 no 1492 0.463578135468518 2078 5282165 A P450 substrate.
SGTC_2636 apigenin dimethyl ether 100 µM 0.0902754710716225 0.451258937018239 no 1493 0.464034155898508 2176 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_79 0052-0007 94.094 µM 0.0901015083645525 0.451325409540881 no 1494 0.464103275297738 2243 2801472
SGTC_1519 esterone 74 µM 0.0898183067512415 0.451433626030135 no 1495 0.464215800152619 2057 698 A steroid.
SGTC_1493 4348-0038 111 µM 0.0888253578208253 0.451813078342955 no 1496 0.464610352357902 2248 800424
SGTC_3289 9119912 71.43 µM 0.086932336243929 0.452536612279087 no 1497 0.465362648101092 2215 17014829
SGTC_2291 7917025 104.35 µM 0.0863969811649913 0.452741259652319 no 1498 0.465575423320195 2186 2964612
SGTC_1197 1601-0112 267 µM 0.0861500214062384 0.452835667896334 no 1499 0.465673580032742 2222 7350313
SGTC_1684 st024538 14.6195 µM 0.0850147888555205 0.453269680960423 no 1500 0.466124816734257 2175 6732859
SGTC_3082 9117008 49.47 µM 0.0840735612068941 0.453629565968263 no 1501 0.466498972652312 2130 41448529
SGTC_3350 9150499 3.57 µM 0.0836726606569334 0.4537828646934 no 1502 0.466658347267633 2260 4910996 YPR165W RHO1
SGTC_709 3807-1509 243 µM 0.0830775732532005 0.454010430427654 no 1503 0.466894929070793 2257 1886677 YPL242C IQG1
SGTC_283 0987-0079 11.7 µM 0.0789921590056364 0.455573126168113 no 1504 0.468519429891478 2241 411556
SGTC_741 4582-0002 126 µM 0.0787720864739549 0.455657324980645 no 1505 0.468606953402233 2201 2912688
SGTC_2685 mycophenolic acid 18.85 µM 0.0782194946348966 0.455868753033518 no 1506 0.468826727524885 2243 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3083 9117465 49.47 µM 0.077917201921167 0.455984419027485 no 1507 0.468946957928046 2109 16420915
SGTC_1529 apigenin 74 µM 0.0770987379868797 0.456297605854734 no 1508 0.469272498477247 2263 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.0759301338466698 0.456744821531543 no 1509 0.469737341356203 2279 756377
SGTC_1030 k029-0042 36.7 µM 0.0744160922050997 0.457324314840948 no 1510 0.470339652288812 2142 6080581
SGTC_2507 purpurin 79.67 µM 0.0731439192268865 0.457811304111481 no 1511 0.470845796372397 2260 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1138 3761-0006 1.03 µM 0.0729040882298511 0.457903118810042 no 1512 0.470941220333176 2269 12061087
SGTC_807 1315-0151 48 µM 0.0723674774244054 0.45810855809668 no 1513 0.471154733083431 2291 4011080
SGTC_1775 st081588 35.1725 µM 0.0711025652301321 0.458592868824991 no 1514 0.471658063290973 2275 1426443 YGL099W LSG1
SGTC_3274 9138298 49.47 µM 0.0707571804140291 0.458725120791047 no 1515 0.471795505721566 2295 17015756
SGTC_11 0438-0307 1.3 µM 0.0704586535305105 0.458839433977313 no 1516 0.471914304213768 2291 4011476
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.0699367206269118 0.45903930292086 no 1517 0.472122012918541 2282 6708561
SGTC_908 3448-7491 47.7 µM 0.0696902327433683 0.459133696573586 no 1518 0.472220108011234 2239 1203031
SGTC_2173 5763948 167 µM 0.0692624881023478 0.459297508788872 no 1519 0.472390342079345 2285 2867177
SGTC_660 4031-1742 102 µM 0.0691472426921317 0.459341645196785 no 1520 0.47243620838042 2244 6738706
SGTC_350 k064-0020 19.8 µM 0.0687651750457222 0.459487972119687 no 1521 0.472588269365672 2288 2790705
SGTC_2084 5306078 60.6385 µM 0.0673144964428613 0.460043612906194 no 1522 0.473165668286264 2231 679340
SGTC_1710 st031758 61.5 µM 0.0662562327248793 0.460448999730788 no 1523 0.473586913921473 2279 5394341
SGTC_2057 5236571 38.335 µM 0.0662502282555289 0.460451299967743 no 1524 0.47358930410656 2260 54684039 YBR257W POP4
SGTC_1081 sertraline 6 µM 0.0662054237263797 0.460468464063109 no 1525 0.47360713937082 2292 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1349 flufenamic acid 69 µM 0.0639385726039344 0.461336963883299 no 1526 0.474509569301317 2268 3371 A non-steroidal anti-inflammatory.
SGTC_1900 st060200 72.8 µM 0.0637255792721163 0.461418577669166 no 1527 0.474594368412139 2277 688945
SGTC_142 0335-0849 62.6745 µM 0.063640133642855 0.461451318781465 no 1528 0.474628387234558 2282 3889043 YPR107C YTH1
SGTC_2465 5809242 33.21 µM 0.0630840684771075 0.461664398569536 no 1529 0.474849780271134 2302 2731748
SGTC_2937 9044753 11.33 µM 0.0621848200535144 0.462009006737876 no 1530 0.475207825467756 2296 6465530 YGL099W LSG1
SGTC_2839 9003951 25.97 µM 0.0621755833738062 0.462012546548084 no 1531 0.475211503253092 2336 2990634
SGTC_2028 5153890 36.43 µM 0.0621426372325124 0.462025172655873 no 1532 0.475224621494499 2272 2830968 YPR165W RHO1
SGTC_1448 4255-0083 152 µM 0.0619728546797209 0.4620902398446 no 1533 0.475292224632409 2297 5399660
SGTC_281 1672-3440 14.9 µM 0.0619131704335343 0.462113113378908 no 1534 0.475315989565648 2272 6833000
SGTC_2865 9030313 51.95 µM 0.0614213265561103 0.462301613575519 no 1535 0.475511834143753 2284 42562754
SGTC_2087 5276107 200 µM 0.0598838216682905 0.462890919957374 no 1536 0.476124082603457 2297 144405
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.0578795778894562 0.463659243617678 no 1537 0.476922275165092 2279 442882
SGTC_906 1165-0455 526 µM 0.0565185299423829 0.464181076642343 no 1538 0.477464367179498 2323 3252859
SGTC_407 eburnamonine 100 µM 0.0564373869146903 0.464212189266194 no 1539 0.477496686976673 2287 3195
SGTC_1867 st057372 64 µM 0.0555634836445029 0.464547283319267 no 1540 0.477844777686206 2300 688837
SGTC_401 neomycin 50 µM 0.0545319351142403 0.464942858040082 no 1541 0.478255682946252 2215 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_579 4491-1009 110 µM 0.0531230003548793 0.465483207453656 no 1542 0.478816952845811 2333 1271041
SGTC_2629 bisabolol 100 µM 0.0520087706590462 0.465910577797834 no 1543 0.47926085244923 2265 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2993 9054257 71.4286 µM 0.0513397440405291 0.466167206409235 no 1544 0.479527399340833 2312 6470217 YGL055W OLE1
SGTC_720 r052-1644 49.9 µM 0.050452554118977 0.466507540882591 no 1545 0.479880878773347 2267 1422863 YOR257W CDC31
SGTC_2965 9082772 38.63 µM 0.0499863058144649 0.466686407990266 no 1546 0.48006665052838 2314 16459634
SGTC_1664 st014217 9.02 µM 0.0496545663430504 0.466813677495005 no 1547 0.480198831285834 2314 3982782
SGTC_914 3820-6779 408 µM 0.0491587269887391 0.467003909082662 no 1548 0.480396401283485 2325 2893481
SGTC_133 0724-0033 378.92 µM 0.0490188609312903 0.467057570855668 no 1549 0.48045213257876 2325 280309
SGTC_1750 st081859 2.357 µM 0.0488732547309242 0.467113435559258 no 1550 0.480510151508227 2287 5291695
SGTC_876 0720-0963 56.8 µM 0.0464551200276662 0.468041294728244 no 1551 0.481473752234545 2326 765861
SGTC_1972 st070201 17.4 µM 0.0464219727764788 0.468054014832753 no 1552 0.481486961823346 2321 2829099
SGTC_1052 3253-3998 198 µM 0.0463091663593116 0.468097304018499 no 1553 0.481531916725391 2317 5450317
SGTC_1486 3970-0793 4.53 µM 0.0458781792549347 0.468262697731658 no 1554 0.481703673146222 2332 2844330
SGTC_1299 1079-1439 3.74 µM 0.0440673913756683 0.468957657242542 no 1555 0.482425342717552 2307 323161
SGTC_2450 5739737 12.93 µM 0.0438111410085217 0.469056010868223 no 1556 0.482527473185936 2269 2262825
SGTC_577 r071-0003 38.6 µM 0.0436234638292937 0.469128046035679 no 1557 0.482602274033738 2329 4568517 YMR134W ERG29
SGTC_77 0828-0286 12.516 µM 0.0431485657747772 0.469310328224636 no 1558 0.482791552716916 2321 745345
SGTC_3313 9133968 57.047 µM 0.0424901469496312 0.469563062624109 no 1559 0.483053983126712 2330 1494643
SGTC_965 1291-5240 308 µM 0.0417846572642483 0.469833878804514 no 1560 0.483335183030182 2318 2834598
SGTC_593 1203-0218 61.7 µM 0.0413356220663413 0.47000625712922 no 1561 0.483514167512702 2350 3666956
SGTC_457 grayanotoxin iii 135 µM 0.0406399052176449 0.470273344175307 no 1562 0.483791485328864 2278 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1762 st045503 25.4615 µM 0.0400993422533663 0.470480876583481 no 1563 0.484006963093597 2298 4645554
SGTC_694 1315-0438 43.2 µM 0.0397056307820358 0.470632034958822 no 1564 0.48416390625192 2296 6793154
SGTC_1300 1094-0077 113 µM 0.0387384930725249 0.471003367852959 no 1565 0.484549441698011 2326 5532636
SGTC_2267 7931562 200 µM 0.038398361013203 0.471133967696682 no 1566 0.484685033870953 2320 934880
SGTC_2557 derrustone 83.84 µM 0.037800725157546 0.471363448281998 no 1567 0.484923283097417 2183 629853 An antioxidant.
SGTC_3189 9110682 49.47 µM 0.0369421470308269 0.471693142264566 no 1568 0.485265567098146 2309 17122418
SGTC_2113 5491891 107.031 µM 0.0353860671544733 0.472290726188704 no 1569 0.485885947277459 2317 789979
SGTC_3323 9138564 53.9225 µM 0.0332274542415784 0.473119804871352 no 1570 0.486746602443685 2348 43912313 YNL103W MET4
SGTC_2449 5812982 45.77 µM 0.0317477768562339 0.473688185919727 no 1571 0.487336596824731 2362 776185
SGTC_1835 st008666 49.2 µM 0.0312520179634333 0.473878631333169 no 1572 0.48753427790771 2312 690455
SGTC_2283 7944793 200 µM 0.0286966955102974 0.474860350307146 no 1573 0.488553245942325 2336 2970533
SGTC_2533 agelasine 13.65 µM 0.0284550395849684 0.47495319911159 no 1574 0.48864961335412 2348 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_3086 9117350 49.47 µM 0.0284484269724567 0.474955739822277 no 1575 0.488652250337298 2361 2679265
SGTC_696 1560-0013 611 µM 0.0272603419120367 0.475412244577733 no 1576 0.489126043836795 2339 1650269
SGTC_722 3534-0461 190 µM 0.027226918375586 0.475425087564979 no 1577 0.48913937295119 2344 658262
SGTC_3268 9137683 49.47 µM 0.0271738133955709 0.475445493195514 no 1578 0.489160550937195 2350 1953228
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.025970250647182 0.475907980299553 no 1579 0.489640533494434 2348 3256 An antibiotic and ribosome inhibitor.
SGTC_2997 9067075 71.4286 µM 0.0255205749664712 0.476080783311694 no 1580 0.489819868690537 2333 27209819
SGTC_1573 oleylamine 1.06 µM 0.0245763934562625 0.476443631430079 no 1581 0.490196424452275 2337 5356789 An amine of the fatty acid oleic acid.
SGTC_718 1130-0073 349 µM 0.0242613892793033 0.476564691616684 no 1582 0.490322055475089 2335 6740020
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.0241792165355481 0.476596272022966 no 1583 0.490354828042878 2369 5024745
SGTC_2897 9048598 12.99 µM 0.0237811619943653 0.476749253343025 no 1584 0.490513583175623 2350 6467404
SGTC_2761 levamisole 97.89 µM 0.0232757214492913 0.476943510456834 no 1585 0.490715168971719 2367 26879 An alkaline phosphatase inhibitor.
SGTC_1654 st012436 41.8 µM 0.0229568126002045 0.477066080241889 no 1586 0.490842361206799 2365 4323132
SGTC_428 3448-4153 16.5 µM 0.0228604035913263 0.477103134616212 no 1587 0.490880812745546 2355 3834874
SGTC_2497 7-hydroxyflavone 100 µM 0.0224225133168081 0.477271438285 no 1588 0.491055460917657 2360 5281894
SGTC_982 1491-0518 27.5 µM 0.0220757917034994 0.477404704043374 no 1589 0.491193748595891 2343 3091256
SGTC_3148 9097893 49.47 µM 0.0211051123421547 0.477777807303995 no 1590 0.491580903372494 2343 17174100
SGTC_2943 9068529 45.32 µM 0.0197816383511689 0.478286546731909 no 1591 0.492108782745731 2375 3270634
SGTC_2486 5283202 22.39 µM 0.0193666640984092 0.4784460689139 no 1592 0.492274301807111 2342 1377751
SGTC_1805 st050013 60.3 µM 0.0188262165847585 0.478653830028688 no 1593 0.492489869858402 2350 4037144
SGTC_952 1185-0122 232 µM 0.0186492060842575 0.478721878416355 no 1594 0.492560474435249 2365 678600
SGTC_1919 st067113 52.3 µM 0.0178650537486554 0.479023338599084 no 1595 0.492873253815592 2342 1268243
SGTC_1650 st011916 45.8 µM 0.0170002232290053 0.479355828679713 no 1596 0.493218218843632 2368 242528
SGTC_3025 9087895 49.47 µM 0.0168867327253079 0.479399461960833 no 1597 0.49326348850545 2376 17173641
SGTC_756 0508-1999 28.3 µM 0.0157790045769231 0.479825359056725 no 1598 0.493705349136568 2363 6753853
SGTC_2368 9071271 200 µM 0.0154830201457829 0.479939162476519 no 1599 0.493823415415697 2358 27209959
SGTC_2967 9089538 49.85 µM 0.0153148001370216 0.480003842325 no 1600 0.493890517533207 2377 728216
SGTC_2308 7584454 197.62 µM 0.014818806029329 0.48019455292144 no 1601 0.494088368093409 2371 893577
SGTC_1315 1237-0019 3.69 µM 0.0134422372056658 0.480723869642908 no 1602 0.494637484731452 2385 825140
SGTC_2399 5884133 200 µM 0.0120210952495606 0.481270361222816 no 1603 0.495204392348093 2382 722445
SGTC_2364 9055074 200 µM 0.012003017710741 0.481277313060393 no 1604 0.495211603722372 2380 6470630
SGTC_2335 9018011 154.17 µM 0.0115092203866981 0.481467208294553 no 1605 0.49540858673826 2378 6458208
SGTC_1132 3456-3614 2.5 µM 0.0113137170124237 0.481542392448499 no 1606 0.495486576221971 2381 3125502
SGTC_70 0141-0289 43.283 µM 0.0111383182885676 0.481609845575322 no 1607 0.495556545779714 2321 352408
SGTC_3263 9137018 49.47 µM 0.0107729374178609 0.481750361867727 no 1608 0.495702302909109 2373 43844957
SGTC_2403 6032726 181.2 µM 0.0106996928386246 0.481778530163933 no 1609 0.495731521584526 2377 2881040
SGTC_1057 3448-5381 134 µM 0.00982097397867777 0.48211647366652 no 1610 0.496082061227149 2383 5497911
SGTC_2414 st077232 92.9 µM 0.00955295198326431 0.482219553904387 no 1611 0.496188981516206 2377 729801
SGTC_2862 9027634 71.43 µM 0.00933439783162732 0.482303609878216 no 1612 0.49627616811981 2378 5012562
SGTC_3341 9147222 25.867 µM 0.00679721864434267 0.483279466147303 no 1613 0.497288322974554 2386 1939759
SGTC_1913 st060213 96.1 µM 0.00614260942840478 0.483531260089148 no 1614 0.497549468797458 2392 688959
SGTC_2890 9046729 58.44 µM 0.00605436109568392 0.483565205113665 no 1615 0.497584674133867 2388 903329
SGTC_2433 5607874 27.82 µM 0.0048261788033515 0.484037641909573 no 1616 0.498074640696814 2393 2252428
SGTC_2664 lyso-paf C-16 73.48 µM 0.00396292312862975 0.48436971823698 no 1617 0.498419026548145 2399 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2958 9077254 16.72 µM 0.00294291760527052 0.484762106893912 no 1618 0.498825947434219 2391 16457351
SGTC_2060 5238662 140 µM 0.00280986926640204 0.484813290711812 no 1619 0.498879025822315 2399 790130
SGTC_2812 7970281 58.44 µM 0.00280934371073029 0.484813492894057 no 1620 0.498879235487866 2398 2233435
SGTC_1986 st071812 45 µM 0.00257949672545025 0.484901915830692 no 1621 0.498970930835265 2400 11838594
SGTC_2412 st077135 33.4 µM 0 0.485894307118806 no 1622 0.5 2406 13258915
SGTC_2924 9010168 62.78 µM -0.00011314977900465 0.485937840467362 no 1623 0.499954859769233 2406 2993929
SGTC_1043 0916-0009 19.3 µM -0.000592397897353662 0.486122228674827 no 1624 0.499763667445748 2406 3101130
SGTC_1280 0880-0253 10.1 µM -0.000685302511149161 0.486157973583734 no 1625 0.499726603874837 2407 6836607
SGTC_3187 9109394 49.47 µM -0.00185465202171441 0.486607888444503 no 1626 0.499260101317282 2414 17098090
SGTC_2729 fluphenazine 10.66 µM -0.0022120376307489 0.486745398319019 no 1627 0.49911752538293 2410 3372 An atypical antipsychotic.
SGTC_1458 k015-0034 6.33 µM -0.00243326876772527 0.486830521356212 no 1628 0.499029267166893 2414 3598957
SGTC_974 1326-0144 138 µM -0.00286129743830129 0.486995215517447 no 1629 0.498858509032626 2415 5411856
SGTC_585 0kpi-0023 191 µM -0.00312433384808373 0.487096426103533 no 1630 0.498753573157735 2408 64601
SGTC_144 4161-2749 112.381 µM -0.00383597010133797 0.487370252123354 no 1631 0.498469673093263 2410 797501 YMR168C CEP3
SGTC_1170 0310-0127 64.8 µM -0.00417913502417092 0.48750229852274 no 1632 0.498332771196425 2418 774975
SGTC_34 0469-0683 81.75 µM -0.00525098702732763 0.487914745114345 no 1633 0.497905168887713 2416 3690923
SGTC_2791 5663188 71.43 µM -0.00722339729173173 0.488673758249795 no 1634 0.497118306472125 2418 54690634
SGTC_2739 tacrine 100.86 µM -0.00785315040815361 0.488916105491761 no 1635 0.49686707847011 2428 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_3272 9137413 49.47 µM -0.00892258595311056 0.489327664597041 no 1636 0.496440450443648 2420 17614870
SGTC_764 1951-2361 146 µM -0.00947738996647338 0.489541178596775 no 1637 0.496219125034885 2422 5438930
SGTC_1631 benzylvanillin 81.9 µM -0.0102659593007533 0.489844661343532 no 1638 0.495904546722758 2441 75506
SGTC_2663 amphotericin b 100 µM -0.0105770205424411 0.489964375614391 no 1639 0.495780457980819 2432 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1793 st048256 72.231 µM -0.0113985071846128 0.490280535278189 no 1640 0.495452752018409 2426 672022
SGTC_2170 morpholine 200 µM -0.0114405510077741 0.490296716548399 no 1641 0.495435980053337 2429 121171 Reacts with secondary amines.
SGTC_1651 st011928 86.1 µM -0.0119604350474037 0.490496803948208 no 1642 0.495228590527817 2439 720198
SGTC_3062 9077494 49.47 µM -0.0125608334483417 0.490727881825294 no 1643 0.494989084226542 2420 16459633
SGTC_1255 0566-0045 221 µM -0.0127142418956484 0.490786925286806 no 1644 0.49492788799774 2450 2788469
SGTC_2892 9047358 58.44 µM -0.0134078739262607 0.491053891157938 no 1645 0.494651192461157 2437 6466771
SGTC_1213 1315-0166 115 µM -0.0135885967840672 0.49112344863636 no 1646 0.494579101040154 2463 768401
SGTC_3147 9097027 49.47 µM -0.0144096681030152 0.491439469862726 no 1647 0.494251573080334 2442 25236841
SGTC_1239 0337-0584 35.4 µM -0.0154544854538071 0.491841616193698 no 1648 0.493834797748907 2436 914301 YML130C ERO1
SGTC_470 aa-861 153 µM -0.0157536078199733 0.49195674883001 no 1649 0.49371547971751 2440 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_136 0097-0015 404.482 µM -0.0163887346904091 0.492201212301537 no 1650 0.4934621334793 2427 4861337
SGTC_2415 st077333 57.7 µM -0.0165634002004321 0.492268442437061 no 1651 0.493392461479762 2440 2766255
SGTC_1130 3454-2858 15.9 µM -0.0171159989094497 0.492481143485919 no 1652 0.493172037749043 2480 715628 YIL048W NEO1
SGTC_1817 st052116 64.4 µM -0.0179327299384148 0.492795515736984 no 1653 0.492846259246601 2441 4361398
SGTC_2037 5169046 200 µM -0.0191162267802628 0.493251069641203 no 1654 0.492374193348354 2469 5718022
SGTC_1579 chlormadinone acetate 49.4 µM -0.0226254837112865 0.494601909095426 no 1655 0.49097450798332 2444 45114258 A steroidal progestin.
SGTC_3230 9131665 49.47 µM -0.0228411040021658 0.494684911292173 no 1656 0.490888510157765 2453 15943720
SGTC_2245 6637752 200 µM -0.0237953372180521 0.495052242389963 no 1657 0.490507929679389 2452 681890
SGTC_1364 1653-0028 37.6 µM -0.0239375881086538 0.495107002091285 no 1658 0.490451195945048 2475 5718652
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.0243864258598663 0.495279783480415 no 1659 0.490272187850872 2493 5282362
SGTC_3335 9143315 29.6265 µM -0.0264054390120619 0.49605701890974 no 1660 0.489466977979784 2470 4899691
SGTC_2826 7992541 19.48 µM -0.0268612503840275 0.496232489357247 no 1661 0.48928520003536 2443 2985066
SGTC_2914 7968218 45.32 µM -0.0269800175112413 0.496278210410807 no 1662 0.489237835972784 2462 2977111
SGTC_2081 5214970 32.255 µM -0.0276800512428067 0.496547699082367 no 1663 0.488958667204598 2461 2063512
SGTC_1292 0kpi-0043 232 µM -0.0279982572964386 0.496670197888598 no 1664 0.48883177053962 2464 3333905
SGTC_1515 3460-0031 42.1 µM -0.0284352918314509 0.496838442239384 no 1665 0.488657488381346 2464 2876596
SGTC_3251 9135047 49.47 µM -0.0289081628513453 0.497020483125806 no 1666 0.488468917664992 2476 17682963
SGTC_3084 9116877 49.47 µM -0.0295082565271525 0.497251501733755 no 1667 0.488229617026896 2455 27241325
SGTC_2879 9041815 71.43 µM -0.029794109923217 0.497361547304368 no 1668 0.488115628141709 2452 4942971
SGTC_466 geldanamycin 89.2 µM -0.0304419773039085 0.497610958874289 no 1669 0.487857283654247 2472 5288382 HSP90 inhibitor.
SGTC_1676 st018489 23.4 µM -0.0315593170649374 0.498041106861034 no 1670 0.487411743747474 2503 3696235
SGTC_3114 9122766 49.47 µM -0.0321705586824872 0.498276420659794 no 1671 0.487168017394633 2503 17176985
SGTC_1508 1080-0625 72.9 µM -0.032199994231738 0.498287752677061 no 1672 0.487156280390199 2437 767111
SGTC_641 4092-0595 30 µM -0.0330139226789876 0.498601097140297 no 1673 0.486831742500761 2488 786260
SGTC_2262 9014885 67.46 µM -0.0330303492116037 0.498607421001839 no 1674 0.486825192834434 2513 6457424
SGTC_2482 5981709 142.65 µM -0.033941267267321 0.498958105352025 no 1675 0.486461992805648 2515 877755
SGTC_263 alizarin 107.927 µM -0.0352007066664378 0.499442964380317 no 1676 0.485959849371731 2456 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2408 sulbentine 18.36 µM -0.0355906562974269 0.499593087404479 no 1677 0.485804379398806 2587 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1266 0828-0227 32.9 µM -0.0360999112834514 0.499789140753568 no 1678 0.485601346534354 2496 3913820
SGTC_820 1582-0060 59.9 µM -0.0371953385722665 0.499789140753568 no 1679 0.485164627661345 2490 3848840
SGTC_763 3453-1109 128 µM -0.0373192815920066 0.499741425074604 no 1680 0.485115215856785 2462 1560353
SGTC_993 3909-8757 62.7 µM -0.0382395176544269 0.499387152049688 no 1681 0.48474835669584 2511 4288324 YLR208W SEC13
SGTC_1903 st060211 78.3 µM -0.0384096654153877 0.499321648508418 no 1682 0.484680527391424 2466 688960
SGTC_632 0781-2353 4.65 µM -0.0385562758598646 0.499265206385633 no 1683 0.484622081579795 2509 6811515 YHR007C ERG11
SGTC_3070 9117005 49.47 µM -0.0409099035968536 0.498359109025037 no 1684 0.483683861064946 2466 8779016
SGTC_2386 9075165 157.42 µM -0.041063042314284 0.498300154070532 no 1685 0.483622818849529 2487 16452277
SGTC_446 go6976 132 µM -0.0413583842915408 0.498186454172177 no 1686 0.483505094457522 2479 3501 A protein kinase C inhibitor.
SGTC_1692 fluoroquinolonic acid 71 µM -0.0418142736268787 0.498010947509732 no 1687 0.483323378128178 2571 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_105 0111-0055 734.78 µM -0.0433235849833887 0.497429901100423 no 1688 0.482721795386008 2561 5179370
SGTC_245 methotrexate 289.6 µM -0.0433801665563649 0.497408118735074 no 1689 0.482699243805771 2510 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2754 granisetron 64.02 µM -0.0441994660312465 0.497092711638688 no 1690 0.482372703842217 2508 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1789 tunicamycin 25 nM -0.0442511697636771 0.497072807224777 no 1691 0.482352097199203 2554 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1205 4161-2785 76 µM -0.0455866344625556 0.496558695322389 no 1692 0.48181986112572 2608 3498106
SGTC_233 rapamycin 362 pM -0.0463305566103985 0.496272311119251 no 1693 0.481523392399348 2501 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1341 1486-1360 280 µM -0.0464398800895482 0.496230225533088 no 1694 0.481479825535497 2493 3976547
SGTC_1070 indatraline 8.81 µM -0.0464575087438959 0.49622343914256 no 1695 0.481472800302424 2506 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1735 st034310 56.75 µM -0.0465949684082799 0.496170522210703 no 1696 0.481418021152555 2680 871153
SGTC_799 1310-0557 151 µM -0.0469833756014501 0.496021000046622 no 1697 0.48126323862194 2599 5354492
SGTC_1548 st061468 90.8 µM -0.0473960215422746 0.495862147489011 no 1698 0.481098799904073 2506 390799
SGTC_2553 4-methylesculetin 85.09 µM -0.0485349325132742 0.495423714764314 no 1699 0.480644962557861 2486 5319502
SGTC_1437 4092-1038 11.6 µM -0.0486782250927173 0.495368553540807 no 1700 0.480587864579185 2491 3977136
SGTC_306 1672-3436 11.6 µM -0.0487411947802323 0.495344313060132 no 1701 0.480562773092599 2547 6797378
SGTC_2093 5331342 194.4 µM -0.0487524374130455 0.49533998515697 no 1702 0.4805582932568 2489 33839
SGTC_719 2810-4230 27.3 µM -0.0488803087705593 0.495290760529036 no 1703 0.480507340712985 2486 721079
SGTC_1053 3366-3204 134 µM -0.0489484949915755 0.495264511979845 no 1704 0.480480170869474 2519 3632071 YPR165W RHO1
SGTC_850 0388-0143 75.9 µM -0.049335698427443 0.495115456913535 no 1705 0.480325885456715 2504 67273
SGTC_597 k018-0003 82.8 µM -0.0495725328558781 0.495024287160029 no 1706 0.480231517658677 2553 6786234
SGTC_2237 6667747 47.222 µM -0.049578043941949 0.495022165662603 no 1707 0.480229321753539 2549 729940 YDL015C TSC13
SGTC_2354 9060492 162 µM -0.0496845317543633 0.494981173113357 no 1708 0.480186891553443 2516 6471895
SGTC_1029 k015-0030 64.7 µM -0.0517485612938483 0.494186634658048 no 1709 0.47936452136551 2615 2208316
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0517979394618786 0.494167627034593 no 1710 0.479344848710208 2528 23847180
SGTC_929 2805-0021 398 µM -0.0529650213564914 0.493718374682022 no 1711 0.478879888744974 2592 3098024
SGTC_1018 4259-0013 28.1 µM -0.0550593930941669 0.492912195031393 no 1712 0.478045573330121 2622 6801262
SGTC_2932 9016711 44.54 µM -0.0560395051767863 0.492534933441866 no 1713 0.477655168006259 2509 7117328
SGTC_2814 7977482 42.97 µM -0.0562338568602169 0.492460124999759 no 1714 0.477577754975626 2553 6456762
SGTC_260 nsc-65238 3.989 µM -0.0568004375288826 0.492242042396038 no 1715 0.477352082702441 2498 3246252
SGTC_3241 9133421 49.47 µM -0.0570765002137057 0.492135783925386 no 1716 0.477242128006282 2489 17018221
SGTC_371 0195-0006 7.36 µM -0.0581624435679901 0.491717802170856 no 1717 0.476809617873184 2489 3928593
SGTC_2376 9072922 81.32 µM -0.0585273852876805 0.4915773373967 no 1718 0.476664274786084 2623 17087968
SGTC_231 b-estradiol 524 µM -0.0586118996290472 0.49154480827463 no 1719 0.47663061622278 2504 450 A steroid.
SGTC_1426 4048-4480 71.7 µM -0.0591679832536404 0.491330776046977 no 1720 0.476409155305497 2516 14224343
SGTC_2445 5742597 35.57 µM -0.0596172994139733 0.491157839599614 no 1721 0.47623021996779 2529 1774255
SGTC_788 1182-0090 188 µM -0.0600611761166757 0.490986998366694 no 1722 0.476053455541944 2707 5715185
SGTC_2300 7976697 71.57 µM -0.0620787522617685 0.49021048602068 no 1723 0.475250058797825 2536 2236109
SGTC_3089 9117425 49.47 µM -0.0626208023501149 0.490001871304262 no 1724 0.475034232022828 2573 9401657
SGTC_2829 7992743 58.44 µM -0.0643501020523806 0.489336347371316 no 1725 0.474345730210442 2533 16462845
SGTC_1699 st031318 29.054 µM -0.0650032312945995 0.48908499709528 no 1726 0.474085713748575 2596 5340658
SGTC_2400 5203494 178.7 µM -0.0659955468049501 0.488703122695432 no 1727 0.473690685430972 2527 6777674
SGTC_2817 7995342 71.43 µM -0.0665958377597551 0.488472116751083 no 1728 0.47345172968899 2524 18879975
SGTC_273 hydroxyurea 18.1 mM -0.0681988211515584 0.487855270560609 no 1729 0.472813682686614 2519 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2844 9010103 25.97 µM -0.0692487887142481 0.487451246788257 no 1730 0.472395794253533 2669 2480525
SGTC_2340 7987427 183.45 µM -0.0704080168430304 0.487005194915065 no 1731 0.471934455284034 2596 2239331
SGTC_32 0928-0142 34.1 µM -0.0704116637290932 0.487003791678788 no 1732 0.471933003988885 2539 2244242
SGTC_3092 9117248 49.47 µM -0.0721667455238907 0.486328496336192 no 1733 0.471234604686751 2521 17141857
SGTC_739 1486-1183 203 µM -0.0722500864177427 0.486296430575298 no 1734 0.471201443046621 2533 4346692
SGTC_478 N-arachidonylglycine 10 µM -0.0724756497891706 0.486209644560491 no 1735 0.471111691575542 2541 5283389
SGTC_2808 7946468 45.46 µM -0.0736457476550933 0.485759457346889 no 1736 0.470646134291838 2590 2970879
SGTC_2435 5706476 10.6 µM -0.0737178768008047 0.485731706735536 no 1737 0.470617436930917 2556 5725375
SGTC_2591 skatole 100 µM -0.0739144136322934 0.485656092476513 no 1738 0.470539243401125 2600 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2900 5328528 85.29 µM -0.0743665734459436 0.48548213351276 no 1739 0.470359352827937 2518 795359
SGTC_3256 9138902 49.47 µM -0.0745341827185939 0.485417650075847 no 1740 0.470292671461587 2513 17228773
SGTC_3108 9121785 49.47 µM -0.074743881371833 0.485336974349333 no 1741 0.470209246506357 2503 17140271
SGTC_1804 st050076 49.1 µM -0.0750780251390216 0.48520842306668 no 1742 0.470076315934241 2605 3895976
SGTC_532 1548-0774 215 µM -0.0754828581592962 0.48505267838264 no 1743 0.469915267915425 2707 5932993
SGTC_666 0272-0154 136 µM -0.0761634752976269 0.484790841006755 no 1744 0.469644520371557 2563 6870312
SGTC_1407 3909-7909 12.3 µM -0.0781426038288627 0.484029496404667 no 1745 0.468857308914465 2558 4411780
SGTC_2043 5101342 149 µM -0.0793761588808827 0.483554993348798 no 1746 0.468366715627004 2576 678451
SGTC_485 niflumic acid 177 µM -0.080054093066576 0.483294226987239 no 1747 0.468097116966898 2655 4488 A COX2 inhibitor.
SGTC_3196 9111891 49.47 µM -0.0804358615964268 0.48314738343619 no 1748 0.467945302932376 2516 18891510
SGTC_3298 9116858 71.43 µM -0.0816404122470133 0.48268407982521 no 1749 0.467466332106511 2645 2506942
SGTC_2074 5212007 75.395 µM -0.0818339607060246 0.482609637880244 no 1750 0.467389374947026 2534 758611
SGTC_2588 indole-3-carbinol 100 µM -0.0843511766022979 0.481641531091081 no 1751 0.466388612151413 2631 3712 Induces cell cycle arrest.
SGTC_1348 1493-0373 93.8 µM -0.0850492226709912 0.481373085507045 no 1752 0.466111129202398 2608 3010129
SGTC_912 3474-0017 2.18 µM -0.0886523647255014 0.479987572447997 no 1753 0.464679095422651 2670 3360550
SGTC_1569 carminic acid 40.6 µM -0.0887229834952559 0.479960419835171 no 1754 0.46465103318871 2592 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_448 monastrol 171 µM -0.0889308357984245 0.479880502059882 no 1755 0.464568438605349 2593 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1401 3807-4679 7.6 µM -0.0907807369455903 0.47916926384515 no 1756 0.463833408265648 2566 3291456
SGTC_2259 7964009 200 µM -0.0924181126434041 0.478539791321277 no 1757 0.463182924602324 2738 313134
SGTC_2234 tolnaftate 200 µM -0.0931896382701971 0.478243204555721 no 1758 0.462876453015005 2568 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_427 1354-0053 47.3 µM -0.0951523038757289 0.47748877925871 no 1759 0.462096927007019 2821 6813657
SGTC_1031 k035-0009 16 µM -0.0954855982155634 0.477360672819868 no 1760 0.461964564474827 2728 5180959
SGTC_2792 7535235 81.82 µM -0.0962924354944284 0.477050563102758 no 1761 0.461644159385619 2652 1281891
SGTC_2430 5571206 200 µM -0.0967980011240624 0.476856254889765 no 1762 0.461443405676731 2613 1731771
SGTC_878 0828-0289 13.7 µM -0.0982109562527273 0.476313231503227 no 1763 0.460882391346756 2596 745350 YLR208W SEC13
SGTC_1011 4112-3381 17.4 µM -0.0994325405909079 0.475843790677209 no 1764 0.460397423560169 2753 2877139
SGTC_3134 9127454 49.47 µM -0.0998432427214681 0.475685970065742 no 1765 0.46023438841148 2555 24262820
SGTC_1290 0986-0249 10.2 µM -0.0999825514990571 0.475632438711704 no 1766 0.460179088955912 2605 53329
SGTC_3248 9135562 49.47 µM -0.100525473924713 0.475423817351805 no 1767 0.45996357999981 2609 17650701
SGTC_3201 9113999 49.47 µM -0.100763778134595 0.475332249583255 no 1768 0.459868990654171 2775 16649224
SGTC_2782 7736369 71.43 µM -0.102036391134025 0.474843273545918 no 1769 0.459363894933583 2622 2950836 YOL077C BRX1
SGTC_284 0988-0104 32.6 µM -0.102412949430925 0.474698595799316 no 1770 0.459214452778768 2662 4666532
SGTC_199 4063-0024 41.6 µM -0.1024426099052 0.474687200067679 no 1771 0.459202681870708 2687 306215
SGTC_1942 st076330 65.2 µM -0.102822353645243 0.474541302084374 no 1772 0.459051981825651 2729 24208414
SGTC_1172 0370-0043 85 µM -0.103490607832415 0.474284566356628 no 1773 0.458786801666856 2724 376585
SGTC_2131 toluylene red 5.2905 µM -0.103699260055702 0.474204406706618 no 1774 0.458704006940138 2619 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1854 st056233 32.9 µM -0.103723966396786 0.47419491513635 no 1775 0.458694203402028 2573 5393174
SGTC_1276 0871-0068 94.2 µM -0.104573551028116 0.473868534507563 no 1776 0.458357101415202 2675 3414906
SGTC_292 k038-0015 474 µM -0.108158734208267 0.472491428583962 no 1777 0.456934889099326 2703 46368540
SGTC_493 zm226600 134 µM -0.10848462862483 0.472366265222637 no 1778 0.456805636564833 2762 5240098 A potassium channel opener. YCR052W RSC6
SGTC_3312 9133330 71.43 µM -0.108765760659848 0.472258295541669 no 1779 0.456694140847391 2745 17617324
SGTC_3109 9122853 49.47 µM -0.108769380017377 0.472256905528802 no 1780 0.456692705448467 2663 1234709
SGTC_311 1315-0136 58 µM -0.108969204608603 0.472180163496171 no 1781 0.456613458005915 2731 6759207
SGTC_2471 5466956 24.79 µM -0.110042962000438 0.471767807958796 no 1782 0.456187651519596 2651 724419
SGTC_682 0kpi-0099 17 µM -0.110072383426344 0.47175650965922 no 1783 0.456175984940085 2682 1714895 YML126C ERG13
SGTC_179 1273-0063 6.77 µM -0.110079025540992 0.471753958983777 no 1784 0.456173351124677 2607 3108139
SGTC_265 mycophenolic acid 32.932 µM -0.110206661243567 0.471704945111819 no 1785 0.456122739773856 2825 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_685 1278-0033 54.9 µM -0.111373547577369 0.471256864610092 no 1786 0.455660067757832 2628 3590572
SGTC_2731 amoxapine 43.43 µM -0.111992084654306 0.471019363131893 no 1787 0.455414841309658 2594 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3182 9108849 49.47 µM -0.112315814544336 0.470895063729211 no 1788 0.455286501475049 2671 17133045
SGTC_866 0495-0101 262 µM -0.112618064017026 0.470779014511708 no 1789 0.455166681572698 2631 635694
SGTC_652 0437-0092 114 µM -0.114959596848069 0.469880063680104 no 1790 0.454238573352818 2608 3091274
SGTC_2907 7721985 69.9 µM -0.115012821333943 0.469859631739944 no 1791 0.454217479764908 2658 3267881
SGTC_2755 lomerizine 42.69 µM -0.115099424882848 0.46982638633662 no 1792 0.454183157876182 2655 3949 A calcium channel blocker.
SGTC_2141 5621638 7.665 µM -0.115137134929084 0.469811910255437 no 1793 0.454168213098874 2727 2856238
SGTC_3142 9086498 49.47 µM -0.115567400379876 0.469646743369775 no 1794 0.453997700236674 2662 25236367
SGTC_1738 st035555 74 µM -0.115909170776974 0.469515550983345 no 1795 0.453862263730048 2699 5331140
SGTC_384 k007-0144 5.16 µM -0.116579520730778 0.469258239286733 no 1796 0.453596633568952 2686 6824886
SGTC_3057 9095946 49.47 µM -0.116872671332023 0.469145718389935 no 1797 0.453480477414269 2592 24540043
SGTC_1155 4088-0394 48.2 µM -0.1173957645688 0.468944944031752 no 1798 0.453273220125117 2593 2326248
SGTC_2979 9012552 45.46 µM -0.117822088407278 0.468781317674304 no 1799 0.453104313715677 2635 17100905
SGTC_1510 1123-0200 71.5 µM -0.119232544176439 0.468240011669541 no 1800 0.452545562012343 2812 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1485 3909-9022 254 µM -0.121010614643686 0.467557705945015 no 1801 0.451841313856454 2619 714516
SGTC_3067 9117431 49.47 µM -0.121244635635361 0.467467911236361 no 1802 0.451748635373285 2677 17150885
SGTC_787 4152-0075 138 µM -0.121365964948819 0.467421357387286 no 1803 0.451700586800809 2664 9566539
SGTC_440 fluspirilene 35.1 µM -0.121853108752518 0.467234445639694 no 1804 0.451507676294859 2881 3396 An atypical antipsychotic.
SGTC_1440 4100-1550 40 µM -0.122046478965896 0.467160253605274 no 1805 0.451431104243555 2631 742806
SGTC_2342 7990637 118.86 µM -0.124183080658152 0.466340561540294 no 1806 0.450585159107498 2718 2033102 YER133W GLC7
SGTC_3033 9090887 49.47 µM -0.124725433182771 0.466132514425973 no 1807 0.450370460927449 2642 19325384
SGTC_1826 st055655 41.6 µM -0.125082737779349 0.465995456984206 no 1808 0.450229024608081 2676 676168
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.125191759910678 0.465953638300904 no 1809 0.450185870280584 2649 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1825 st052143 62.6 µM -0.125553743356945 0.465814791475131 no 1810 0.450042590277363 2739 674173
SGTC_1352 1496-0991 99 µM -0.126822632784183 0.465328113598662 no 1811 0.449540391003147 2625 3000039
SGTC_3293 9120939 62.045 µM -0.127083676216908 0.465227997756865 no 1812 0.449437085596434 2749 934087
SGTC_318 1488-0629 67.2 µM -0.127577476467084 0.465038620630955 no 1813 0.449241678315127 2705 3662576
SGTC_1769 st044406 64.4 µM -0.127799973238303 0.464953293573135 no 1814 0.449153635621678 2640 670903
SGTC_578 3460-0051 92 µM -0.128416993229131 0.464716676108665 no 1815 0.448909491922529 2619 2876744
SGTC_1062 mesoridazine 14.2 µM -0.128957901448752 0.464509256571687 no 1816 0.448695480189617 2617 4078 A neuroleptic.
SGTC_2108 5365811 200 µM -0.129503798088022 0.464299933927145 no 1817 0.448479509910664 2723 780283
SGTC_1574 spiramycin 23.7 µM -0.129809968447547 0.464182538021365 no 1818 0.448358387985193 2607 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1695 st026914 34.495 µM -0.130291483017547 0.463997915621754 no 1819 0.448167909099522 2622 3289191
SGTC_405 ebelactone b 50 µM -0.130421176258102 0.463948189940604 no 1820 0.448116606724197 2651 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3258 9138477 49.47 µM -0.130541504124742 0.463902055540777 no 1821 0.448069009758412 2653 4970355
SGTC_2220 6782180 200 µM -0.131197795681631 0.463650438122513 no 1822 0.447809419838906 2647 833803
SGTC_2824 7998404 51.95 µM -0.131202986077152 0.463648448220369 no 1823 0.447807366915974 2633 837851
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.131300747164929 0.463610968587962 no 1824 0.44776870037845 2620 66535 A nucleotide analog.
SGTC_1709 st033179 39.1045 µM -0.132497735750611 0.463152093554704 no 1825 0.447295306922759 2635 573381
SGTC_2331 7980721 200 µM -0.13330679602611 0.462841961634236 no 1826 0.44697537656045 2747 2981221
SGTC_2619 obliquin 87.91 µM -0.134003349922263 0.462574974152482 no 1827 0.446699962736946 2661 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2694 st077685 81.9 µM -0.134367974789341 0.462435221007605 no 1828 0.44655580218407 2631 2838096
SGTC_3238 9133470 49.47 µM -0.134541891538202 0.462368563959184 no 1829 0.446487043768942 2757 3534688
SGTC_886 0866-0150 153 µM -0.135045302208254 0.462175627784244 no 1830 0.446288028195931 2819 271463
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.135672307872593 0.461935335287357 no 1831 0.446040170190786 2681 390807
SGTC_2990 9074105 71.4286 µM -0.135698302443642 0.461925373475119 no 1832 0.446029894880828 2626 6502001
SGTC_89 0302-0250 142.109 µM -0.136750364388533 0.46152221542057 no 1833 0.445614059209421 2607 4203518 YLR208W SEC13
SGTC_2721 ifenprodil 61.44 µM -0.137387568183518 0.461278053329616 no 1834 0.445362228510217 2767 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2423 st077119 87.2 µM -0.137728952661461 0.461147248512738 no 1835 0.445227318270279 2580 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1123 mangostin 811.285 nM -0.137789731324544 0.461123961011197 no 1836 0.445203300080764 2741 5281650 An antioxidant.
SGTC_2219 9098279 200 µM -0.13833510287979 0.460915006467343 no 1837 0.44498779205438 2661 902349
SGTC_1230 0170-0365 3.77 µM -0.138380166568272 0.460897741174391 no 1838 0.444969985495997 2739 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_300 r073-0011 5.04 µM -0.13900771190307 0.460657316820331 no 1839 0.444722027499861 2653 2735780
SGTC_90 0870-0863 4.608 µM -0.139510469170744 0.460464711480439 no 1840 0.444523391819736 2633 1738164
SGTC_1004 4084-0029 199 µM -0.140058784222273 0.46025466361717 no 1841 0.444306772480324 2773 716894 YLR208W SEC13
SGTC_1787 fluconazole 80 µM -0.141138501219705 0.459841079419941 no 1842 0.443880264244765 2689 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1765 st044815 90.4 µM -0.141449317560657 0.459722029657816 no 1843 0.443757498052243 2731 645695
SGTC_1567 st069303 68.4 µM -0.14318763563098 0.459056280983164 no 1844 0.443070997268044 2761 5581319
SGTC_3199 9111318 49.47 µM -0.143430171138956 0.458963402755547 no 1845 0.442975228093169 2764 8548020
SGTC_1841 st054148 70 µM -0.14356567283728 0.458911513771471 no 1846 0.442921724446521 2733 675442
SGTC_183 3914-0051 30.55 µM -0.143666744714789 0.458872809789541 no 1847 0.442881816295834 2742 1596232
SGTC_3236 9132701 49.47 µM -0.143975580843935 0.458754547974784 no 1848 0.44275987618745 2701 24282524
SGTC_2055 5235184 200 µM -0.144485662903904 0.458559231578098 no 1849 0.442558488501792 2788 2836034
SGTC_3337 9144342 33.5465 µM -0.146570787373547 0.457760917528992 no 1850 0.441735406455495 2760 17682949
SGTC_1708 st033234 31.827 µM -0.147337328417714 0.457467481074163 no 1851 0.441432885079426 2771 674664
SGTC_3249 9135183 49.47 µM -0.151478090076633 0.455882777880492 no 1852 0.439799296490718 2848 4902779
SGTC_266 formosanin C 406 nM -0.151788711240446 0.455763928608633 no 1853 0.439676793044051 2702 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_752 1896-0090 130 µM -0.151883812408858 0.455727541973589 no 1854 0.439639287993816 2670 772567
SGTC_2933 9026794 32.47 µM -0.151900815763611 0.455721036363262 no 1855 0.439632582437442 2727 17586027
SGTC_2756 carbadox 75.1 µM -0.152218511074245 0.455599485953388 no 1856 0.439507297183009 2715 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_323 4013-0906 34.3 µM -0.152438380448148 0.455515366236276 no 1857 0.43942059378271 2791 2910086
SGTC_2031 5180455 200 µM -0.156269516320539 0.454049937232103 no 1858 0.437910291782818 2679 29949
SGTC_1196 1588-0294 184 µM -0.157455235293834 0.453596519463654 no 1859 0.437443042409423 2735 6144269
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.157890297405926 0.45343016727569 no 1860 0.43727162185568 2741 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1816 st051957 91.6 µM -0.159942891739064 0.452645439330314 no 1861 0.436463030348486 2703 674121
SGTC_932 2857-0803 154 µM -0.160152921236472 0.45256515326869 no 1862 0.436380307008783 2924 674898
SGTC_1668 st014914 51.6 µM -0.16073282582493 0.452343488506892 no 1863 0.436151917148404 2687 2839556
SGTC_460 trequinsin 123 µM -0.160906943214727 0.452276936161961 no 1864 0.436083346836246 2701 5537 A vasodilator.
SGTC_2905 7799065 20.05 µM -0.161511557446383 0.452045846780576 no 1865 0.435845254667631 2798 1296806
SGTC_1494 4358-1428 177 µM -0.162228990667078 0.451771657977061 no 1866 0.435562765466379 2809 1564571
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.164920936105997 0.450743055760699 no 1867 0.434503106705786 2686 23665772 A membrane-active detergent.
SGTC_1741 st038134 10.228 µM -0.166757612883667 0.450041444208951 no 1868 0.433780385806532 2879 1272587
SGTC_1850 st056238 17 µM -0.168805295352323 0.449259412513863 no 1869 0.432974896506923 2677 5393177
SGTC_1185 1319-0113 81.3 µM -0.170997144377389 0.448422540508277 no 1870 0.432113005491529 2813 4672763
SGTC_1449 4112-4002 201 µM -0.171749507255733 0.448135332820283 no 1871 0.431817231448682 2729 2059539
SGTC_2038 4100038 30.985 µM -0.171788087670823 0.448120605829083 no 1872 0.431802065480634 2810 3596803
SGTC_72 0744-0168 198.391 µM -0.172225358309599 0.447953695031743 no 1873 0.431630181345515 2727 677577
SGTC_2177 5811945 192 µM -0.172993743637173 0.447660416618847 no 1874 0.431328172668041 2862 5343475
SGTC_1770 st043884 66.3 µM -0.173054695236844 0.447637153747666 no 1875 0.431304217768478 2707 670149
SGTC_979 1426-2828 121 µM -0.173277126049199 0.4475522620271 no 1876 0.431216801242777 2845 747872
SGTC_1050 3232-1156 69.3 µM -0.175797565437371 0.446590493764866 no 1877 0.430226491175532 2759 700529
SGTC_2233 sulbentine 40.3845 µM -0.175853974559761 0.446568972319 no 1878 0.430204332368949 2730 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2144 5628481 200 µM -0.175933966203127 0.446538453840277 no 1879 0.430172910180137 2716 2818399
SGTC_1872 amphotericin b 148 nM -0.178260743001217 0.445650879301565 no 1880 0.429259103762451 2841 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2734 clemastine 41.6 µM -0.178583140606641 0.445527918577388 no 1881 0.429132516758351 2697 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1583 clindamycin 39.6 µM -0.178665034836156 0.445496685389852 no 1882 0.42910036276301 2716 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2091 4-phenylthiadiazole 200 µM -0.179169331936159 0.445304361768711 no 1883 0.428902371806431 2742 270010
SGTC_54 0159-0055 9 µM -0.179812892801111 0.445058945871462 no 1884 0.428649730801763 2940 3319099
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.181415829864358 0.444447772597502 no 1885 0.428020597299486 2806 279621
SGTC_1989 st071868 50.2 µM -0.181565314662826 0.444390783236926 no 1886 0.427961935616294 2866 16414057
SGTC_3078 9116413 49.47 µM -0.181627655916645 0.444367016690368 no 1887 0.427937471773782 2689 17177322
SGTC_746 1095-0025 46.6 µM -0.181808718296887 0.444297990860738 no 1888 0.427866421171611 2895 6749286
SGTC_1392 3455-1037 33.9 µM -0.183355344265414 0.443708444672794 no 1889 0.427259605960974 2869 981132
SGTC_949 1165-0505 146 µM -0.183951500811431 0.443481233636471 no 1890 0.427025751150119 2753 6244267
SGTC_1938 st074717 56.4 µM -0.185318446137086 0.44296032486152 no 1891 0.426489635343456 2690 17250979
SGTC_1561 5-methoxyflavone 52.9 µM -0.185785848808261 0.442782231929851 no 1892 0.426306351172469 2729 94525
SGTC_673 1082-0474 110 µM -0.185975901436566 0.442709820094076 no 1893 0.426231829749524 2751 3098046
SGTC_1245 0418-0076 17.2 µM -0.187441853354097 0.44215134313952 no 1894 0.425657104924298 2920 6790114
SGTC_2389 9091542 195.52 µM -0.188213467258226 0.441857431050066 no 1895 0.425354657902189 2800 3626624 YOL127W RPL25
SGTC_647 0140-0236 81 µM -0.188239319739613 0.441847584247323 no 1896 0.425344525347597 2771 990837
SGTC_55 0767-0285 6.563 µM -0.188314178034841 0.441819072105085 no 1897 0.425315185859394 2849 3116166
SGTC_374 0880-0231 82.3 µM -0.189423570263417 0.441396560508457 no 1898 0.424880426233564 2813 6833587
SGTC_431 k089-0097 107 µM -0.189954490807246 0.441194383189391 no 1899 0.424672396115753 2824 5499420
SGTC_2024 5144227 134 µM -0.190036140279137 0.441163292001801 no 1900 0.424640405336657 2902 3475211
SGTC_786 4544-0069 423 µM -0.190068207331796 0.441151081333071 no 1901 0.424627841398512 2867 748821 YLR208W SEC13
SGTC_1861 st057647 17.4 µM -0.191273615383361 0.440692120100032 no 1902 0.424155615659988 2928 688668
SGTC_1179 1021-1431 9.29 µM -0.191291667246736 0.440685247425205 no 1903 0.424148544561394 2822 2840958
SGTC_826 1683-5028 118 µM -0.191347541974224 0.440663975006906 no 1904 0.424126658016779 2827 722377
SGTC_2320 7373003 200 µM -0.19182185688131 0.440483402503118 no 1905 0.423940874785419 2790 5415828
SGTC_2857 9024691 58.44 µM -0.191843183289157 0.440475283793303 no 1906 0.423932521894317 2859 16478292
SGTC_1877 wortmannin 25 µM -0.192863584346881 0.440086858550052 no 1907 0.423532902517662 2869 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2343 7990716 14.84 µM -0.193191078411887 0.439962207062978 no 1908 0.423404662759823 2763 6456862
SGTC_2019 4016004 108 µM -0.193778892387133 0.43973848699283 no 1909 0.423174507583208 2821 45595336
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.194005301774207 0.439652321452241 no 1910 0.423085865280585 2748 16623 A steroid.
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.195477347862465 0.439092168784147 no 1911 0.422509634698396 2909 5377381
SGTC_1920 st075728 45.7 µM -0.196465862467325 0.438716081072166 no 1912 0.422122774876574 2938 3400306
SGTC_1818 st052136 56.3 µM -0.196605294585825 0.438663037533248 no 1913 0.422068213500948 2801 674169
SGTC_1156 4092-0367 4.88 µM -0.199511459842469 0.43755771023725 no 1914 0.420931339945991 2792 1357585
SGTC_695 3505-6186 243 µM -0.199673337950681 0.43749615596064 no 1915 0.420868033539243 2883 1819379
SGTC_2603 homopterocarpin 100 µM -0.200006843169482 0.437369345111938 no 1916 0.420737614591299 2882 101795 A weak amylase inhibitor.
SGTC_971 1315-0384 26.7 µM -0.200327973093601 0.437247245881382 no 1917 0.420612043287334 2790 6769120
SGTC_2519 cryptotanshinone 88.04 µM -0.200381145933994 0.437227029211088 no 1918 0.420591251912298 2875 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_23 0213-0011 39.996 µM -0.200616279893175 0.437137631669557 no 1919 0.420499313677707 2907 627608
SGTC_2803 7707263 71.43 µM -0.201233604441559 0.436902941185977 no 1920 0.420257958182294 2786 2199229
SGTC_1756 st041558 35.5 µM -0.20125938479973 0.43689314065736 no 1921 0.420247879482338 2927 3955792
SGTC_1980 st071811 45.7 µM -0.202310696073614 0.436493512621063 no 1922 0.419836919305022 2916 4974850
SGTC_3343 9148379 18.9835 µM -0.202819787721555 0.436300018228638 no 1923 0.419637945501978 2912 1955036
SGTC_1946 st076057 65.1 µM -0.203171444961841 0.43616637004504 no 1924 0.41950051548725 2755 953009
SGTC_556 4058-0063 51.5 µM -0.203425124254226 0.436069963141337 no 1925 0.419401382008842 2778 6615692
SGTC_3324 9138759 60.749 µM -0.20413564394665 0.435799961322686 no 1926 0.419123750455318 2894 45595710
SGTC_738 1315-0003 72.4 µM -0.204247192309539 0.435757574978349 no 1927 0.419080167216598 2930 6251474
SGTC_2311 7694451 200 µM -0.204382773261145 0.435706057682 no 1928 0.419027195503776 2846 2163142
SGTC_435 c-PAF 6.7 µM -0.204749322806251 0.435566783687797 no 1929 0.418883991312315 2938 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_852 0418-0143 439 µM -0.205261351397414 0.435372246925121 no 1930 0.418683969118831 2875 5369229
SGTC_2712 st079126 47.7 µM -0.207825628904352 0.434398228477879 no 1931 0.417682560264249 2758 3152970
SGTC_2626 ethyl orsellinate 100 µM -0.208928863180073 0.433979296690628 no 1932 0.417251885897351 2760 75653 A natural product.
SGTC_93 0109-0045 59.227 µM -0.209759172284902 0.433664051809338 no 1933 0.41692781995289 2723 88733
SGTC_898 1000-0849 28.3 µM -0.210534896909724 0.433369569230999 no 1934 0.416625109076378 2764 6751807
SGTC_935 2996-0153 430 µM -0.211354595759 0.433058433240746 no 1935 0.416305291866689 2939 23738523
SGTC_2687 chenodiol 100 µM -0.21142504081935 0.433031696093491 no 1936 0.416277809302911 2878 5702181 A cholesterol synthesis inhibitor.
SGTC_2518 prenyletin 46.28 µM -0.212915753981875 0.432465973811013 no 1937 0.415696337106875 2888 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2072 5231554 129 µM -0.21440426007876 0.431901227209903 no 1938 0.41511590992331 2891 789545
SGTC_1908 st060353 56.5 µM -0.214424052455545 0.431893718818731 no 1939 0.415108193340659 2981 4227716
SGTC_598 3937-0236 20.2 µM -0.214783280693406 0.431757447087176 no 1940 0.414968144385478 2856 1379313
SGTC_1603 st002045 67.8 µM -0.214877941393298 0.431721539297241 no 1941 0.414931241701353 2920 5887985
SGTC_458 nppb 133 µM -0.21557884180819 0.431455683229511 no 1942 0.414658024897738 2964 4549 A chloride channel blocker.
SGTC_3260 9137109 49.47 µM -0.215908478252603 0.431330660717993 no 1943 0.414529544138108 2902 17478346
SGTC_2743 auranofin 4.32 µM -0.215989109552726 0.4313000804142 no 1944 0.414498118268114 2821 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1653 st012112 65 µM -0.216298442570899 0.431182766300534 no 1945 0.414377561490882 2950 720429
SGTC_809 3998-0021 90 µM -0.216958731102543 0.430932373122833 no 1946 0.414120253342956 2950 715485
SGTC_40 0327-0103 19.753 µM -0.217108675228317 0.430875515502475 no 1947 0.414061826677751 2834 409036
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.217165746204236 0.430853875018517 no 1948 0.414039589115167 2757 88881 An O-methylated flavonoid and antioxidant.
SGTC_3306 9127676 59.7925 µM -0.218212735277006 0.430456908897275 no 1949 0.41363168142687 2865 41905287
SGTC_1977 st070720 65.3 µM -0.220539506335717 0.429574965341435 no 1950 0.412725504034128 2913 682188
SGTC_3232 9132874 49.47 µM -0.22164302428953 0.429156808444139 no 1951 0.412295893424171 2793 3784940
SGTC_2837 9008476 45.46 µM -0.221909710642694 0.42905576469012 no 1952 0.412192085496112 3000 2992805
SGTC_1129 3453-1384 223 µM -0.222378026910388 0.428878337416487 no 1953 0.412009807793583 3018 1084452
SGTC_874 0599-0792 117 µM -0.223812855625382 0.428334824843926 no 1954 0.411451463181561 2968 765305
SGTC_2985 9022375 71.43 µM -0.224631035791334 0.428024959287374 no 1955 0.411133159384323 3001 4939335
SGTC_3053 9095903 49.47 µM -0.225033183036567 0.427872672192843 no 1956 0.410976729947574 2845 17174018
SGTC_904 1141-0088 396 µM -0.225361743279971 0.427748259359066 no 1957 0.410848935291758 2844 1378119
SGTC_225 nsc-122657 1.016 µM -0.225694659866933 0.427622204276379 no 1958 0.410719455872151 2925 275685
SGTC_1168 k815-0004 80.5 µM -0.225805696830932 0.42758016303398 no 1959 0.410676273038388 2796 642433
SGTC_1875 nocodazole 6 µM -0.226381616159613 0.427362119446119 no 1960 0.410452312497533 2831 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_160 3453-0671 289.699 µM -0.22675793972714 0.427219654978166 no 1961 0.410305985495919 2837 5322268
SGTC_1523 st012844 44.7 µM -0.227163103790649 0.427066283000659 no 1962 0.410148458318054 2923 4274103
SGTC_1721 st082152 9.2685 µM -0.228093371259669 0.426714178611463 no 1963 0.409786826625057 2774 5296051
SGTC_1085 doxorubicin 7.67 µM -0.229261817336787 0.426272006855374 no 1964 0.409332714246335 2905 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_467 ro 31-8220 72.8 µM -0.229286627196267 0.426262619132891 no 1965 0.40932307330005 2876 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2549 cedrol 20.94 µM -0.229913752642932 0.426025337053541 no 1966 0.409079394753946 2986 6708665 A sedative which affects the nervous system.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.230712266499724 0.425723246433168 no 1967 0.408769171652263 2835 279621
SGTC_1101 ebselen 5.29 µM -0.230836511867063 0.425676246329209 no 1968 0.408720907387053 2971 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_542 3381-0244 89.3 µM -0.231003018206054 0.425613261208196 no 1969 0.408656228626131 2997 1112843
SGTC_2329 6138490 200 µM -0.233759643413494 0.424570776891596 no 1970 0.407585790737524 3074 720019
SGTC_1136 pergolide 1.05886 µM -0.238422538127464 0.422808594984395 no 1971 0.405776694239443 2839 47811 A dopamine receptor agonist.
SGTC_35 0133-0054 64.071 µM -0.238973927078996 0.422600317718675 no 1972 0.405562900120059 2864 99677
SGTC_2010 4012422 159 µM -0.239467184409639 0.422414016961343 no 1973 0.405371669673588 2912 952393
SGTC_3010 9080089 71.4286 µM -0.240585393516189 0.421991739464605 no 1974 0.404938236000829 2944 17027233
SGTC_636 0kpi-0074 126 µM -0.240854399219592 0.421890166232394 no 1975 0.40483398296183 2920 616434
SGTC_2061 5245884 80.95 µM -0.243029741061944 0.421068975477639 no 1976 0.403991178986625 2821 573863
SGTC_2955 9076254 12.21 µM -0.243513012253153 0.420886587254821 no 1977 0.403804003062588 2954 16459619
SGTC_512 prima-1 270 µM -0.245161410069884 0.420264604162013 no 1978 0.403165727504745 2992 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_119 0121-0043 24.815 µM -0.245922082124569 0.419977649968456 no 1979 0.402871274800143 2827 1092378
SGTC_1444 4112-3581 28 µM -0.246145373052739 0.419893424276248 no 1980 0.40278485034347 2839 2877249
SGTC_2290 7904846 200 µM -0.246903158878512 0.419607613637359 no 1981 0.402491585785034 2914 2962154
SGTC_2106 5357045 167.29 µM -0.250122653226939 0.418393806110653 no 1982 0.401246248952028 2957 668842
SGTC_2794 7785382 27.27 µM -0.250552044886675 0.418231976149957 no 1983 0.401080230900329 2874 2205081
SGTC_2893 9048488 25.97 µM -0.250878888060671 0.418108804137336 no 1984 0.40095387370173 2892 6467338
SGTC_945 3381-0768 11.3 µM -0.253433867006397 0.417146228925484 no 1985 0.399966479794871 2992 1126236 YIL048W NEO1
SGTC_2481 5478948 45.16 µM -0.254847153865536 0.416613993212074 no 1986 0.399420576925084 2999 77792
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.256465203466942 0.416004832719422 no 1987 0.398795822859557 3057 6728940
SGTC_2417 cerulenin 830 nM -0.256487586638545 0.415996407353352 no 1988 0.398787182183691 2917 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_938 3126-1755 342 µM -0.257073429400721 0.415775900971881 no 1989 0.398561044333838 3021 1777771
SGTC_516 3992-2719 87.3 µM -0.257375104276216 0.415662363376222 no 1990 0.398444609800696 2793 5350887 YDR037W KRS1
SGTC_2653 dihydrofissinolide 100 µM -0.257587046052687 0.415582601713399 no 1991 0.398362814089597 2905 6857746
SGTC_2647 atorvastatin 60.16 µM -0.25840278972027 0.415275639169876 no 1992 0.398048031904162 2932 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_3123 9126162 49.47 µM -0.258538093843059 0.415224729521228 no 1993 0.397995826658178 2838 25239884
SGTC_1983 st071813 46.9 µM -0.259803984493263 0.414748493451355 no 1994 0.397507488645279 2930 11838595
SGTC_1361 1608-0041 5.61 µM -0.261268328117514 0.414197754422007 no 1995 0.396942794515043 2887 X1361
SGTC_2616 abietic acid 100 µM -0.261567218255672 0.41408536265789 no 1996 0.396827560161434 2991 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2764 methyldopa 94.69 µM -0.261791900833377 0.414000879820884 no 1997 0.396740941783509 3046 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2946 9065502 71.43 µM -0.262955638967127 0.413563366722841 no 1998 0.396292385552812 2889 16489101
SGTC_537 1334-0398 209 µM -0.263315524525641 0.413428087665119 no 1999 0.39615369747285 3046 5846986
SGTC_995 3931-2021 34.6 µM -0.263697544796525 0.41328449953122 no 2000 0.396006493780987 2971 730143
SGTC_834 0312-0008 75.7 µM -0.264350865254979 0.413038965978856 no 2001 0.395754784489409 2858 6385573 YIL048W NEO1
SGTC_670 4204-0025 119 µM -0.264818232208286 0.412863339092484 no 2002 0.3955747454554 2982 719039
SGTC_1634 st006576 41 µM -0.265650387149541 0.412550675577048 no 2003 0.395254238021301 3059 3915356
SGTC_1572 epiandrosterone 68.9 µM -0.265670950893686 0.412542949914036 no 2004 0.395246318718249 2851 441302 A steroid.
SGTC_2757 clomiphene 4.22 µM -0.265763016602076 0.412508361850233 no 2005 0.395210863825829 3097 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_750 4073-0104 132 µM -0.267783146709598 0.411749592877736 no 2006 0.394433122044645 2953 22330957
SGTC_1181 1222-0449 220 µM -0.269582427804958 0.411074053328131 no 2007 0.393740760284222 3063 658318
SGTC_1724 st037281 8.293 µM -0.272022112033285 0.410158496019341 no 2008 0.392802508633313 2865 574124 YDL195W SEC31
SGTC_768 0384-0033 77.3 µM -0.272207828747203 0.41008882080062 no 2009 0.392731111290285 2906 3965305 YMR134W ERG29
SGTC_1888 azatryptophan 97.5 µM -0.274307005070981 0.409301472053583 no 2010 0.391924350820201 2993 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_200 k038-0079 37.545 µM -0.274381874748752 0.409273397038557 no 2011 0.391895585284224 2903 3436683
SGTC_1715 st032160 10.2275 µM -0.274779216390766 0.40912440762708 no 2012 0.391742933303825 3003 5289825
SGTC_980 1473-0395 201 µM -0.275511117811352 0.408850004213145 no 2013 0.391461792718397 2877 768876
SGTC_2570 licareol 100 µM -0.275840504074944 0.408726525762811 no 2014 0.391335286178981 2964 443158
SGTC_2506 ethyl hematommate 54.16 µM -0.277321287137013 0.408171530301776 no 2015 0.390766707779613 2953 3940691 An allergen.
SGTC_474 dl-dihydrosphingosine 5 µM -0.278634798984502 0.407679381959367 no 2016 0.390262552087585 3039 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1978 st071761 42 µM -0.278913821208215 0.407574856277462 no 2017 0.39015548074779 2922 5147680
SGTC_3106 9121286 49.47 µM -0.279080489186443 0.407512423227682 no 2018 0.390091527939652 3097 15943471
SGTC_656 4090-1979 187 µM -0.279174858698299 0.407477073888799 no 2019 0.390055318371749 3024 22330961
SGTC_2005 4024620 188 µM -0.279412229319452 0.40738816190895 no 2020 0.389964243517298 2888 236743
SGTC_1047 2043-3044 82 µM -0.279546633065455 0.407337820375559 no 2021 0.389912677886043 2918 669592
SGTC_1430 4049-0248 69.1 µM -0.280578323302892 0.406951447133377 no 2022 0.389516921959728 3025 22774488
SGTC_885 0865-0106 16.8 µM -0.282104737828433 0.406379963305008 no 2023 0.3889316002274 2905 2793380
SGTC_1158 4092-0494 91.8 µM -0.282873888498271 0.406092071665486 no 2024 0.38863675569224 3038 1148199
SGTC_2232 chlorophetanol 41.5365 µM -0.282978153131564 0.406053049514831 no 2025 0.388596792049156 2955 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2713 st079149 53.4 µM -0.283741278360659 0.405767470199025 no 2026 0.388304329323383 2988 3103253
SGTC_2090 5301565 104.445 µM -0.284585553343305 0.405451581176669 no 2027 0.38798084027288 2915 2056344
SGTC_198 3454-2873 16.191 µM -0.28555177098943 0.405090142360378 no 2028 0.387610723530668 2917 710957
SGTC_726 3448-4391 34.2 µM -0.286510120849024 0.404731726645148 no 2029 0.387243721460121 3093 1356692
SGTC_733 4069-0007 56.1 µM -0.286868927678253 0.404597556106736 no 2030 0.38710634154599 2930 5717425 YNL287W SEC21
SGTC_2551 apiole 73.87 µM -0.286901171716107 0.40458549947193 no 2031 0.387093996644978 2877 10659 A possible DNA adduct former.
SGTC_3192 9110362 49.47 µM -0.287768968967675 0.404261048291985 no 2032 0.386761796104907 2868 16649480
SGTC_172 1112-0046 2.638 µM -0.288288268435192 0.404066924592306 no 2033 0.386563043285455 2939 2802135 YIL048W NEO1
SGTC_319 1348-1596 45.5 µM -0.289069208285222 0.403775039387873 no 2034 0.386264208200235 3106 5380505
SGTC_3162 9099653 49.47 µM -0.289724429019952 0.403530184468078 no 2035 0.386013532926968 3025 25237511
SGTC_1186 1319-0216 26 µM -0.289806792558163 0.403499408021243 no 2036 0.38598202553281 3061 4565136
SGTC_1222 0366-0074 1.18 µM -0.290125499068679 0.403380323893202 no 2037 0.385860114452432 3042 286520
SGTC_2121 5257820 149.641 µM -0.290920193250652 0.403083426848575 no 2038 0.385556178485382 3078 791256
SGTC_2164 5685496 200 µM -0.291012043643513 0.403049115221216 no 2039 0.385521054230494 3019 759046
SGTC_2155 5570423 76 µM -0.292185519694637 0.402610817356665 no 2040 0.385072391209214 2939 797402
SGTC_3229 9132204 49.47 µM -0.292741443922652 0.402403220184958 no 2041 0.384859894603455 2922 17682924
SGTC_856 0433-0016 11.3 µM -0.293693240983079 0.402047857296203 no 2042 0.384496159790029 3007 3911780
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.294332598607918 0.401809192211643 no 2043 0.384251882597893 2896 2333 A French combination drug.
SGTC_2089 5281248 129.67 µM -0.294616723882144 0.401703143155158 no 2044 0.384143342567571 2932 2737878
SGTC_1950 st077106 7.18 µM -0.295143095771009 0.401506695279914 no 2045 0.383942284783111 3014 13831864
SGTC_589 1227-0070 34.1 µM -0.295203934847046 0.401483991060149 no 2046 0.383919048150038 3043 2841384
SGTC_2062 5245942 200 µM -0.295442648237269 0.401394910059363 no 2047 0.383827878945585 2910 1376160
SGTC_2959 9079155 11 µM -0.296572850092253 0.400973220737961 no 2048 0.383396320627694 3093 16189457
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.297726034999384 0.400543075105584 no 2049 0.382956135493241 2961 688801
SGTC_1511 0906-3109 28.5 µM -0.298818997615769 0.400135504080571 no 2050 0.382539077427164 2922 2882180
SGTC_496 calpeptin 138 µM -0.29938322752364 0.399925142561086 no 2051 0.382323829067332 2985 73364 A calpain inhibitor.
SGTC_2581 avocatin a 64 µM -0.29988679774574 0.399737421279599 no 2052 0.382131752504529 2981 6710728 A skin care supplement.
SGTC_1152 3909-8331 15.9 µM -0.300167154495582 0.399632919720811 no 2053 0.382024828721835 2961 16001939
SGTC_151 3013-0144 2.285 µM -0.300849766592342 0.399378509595191 no 2054 0.381764528532437 3126 906558 YHR107C CDC12
SGTC_2858 9025781 8.96 µM -0.301730040691521 0.399050493754624 no 2055 0.38142893289684 3029 4894980 YPL153C RAD53
SGTC_3262 9137218 49.47 µM -0.303182739679619 0.398509331641959 no 2056 0.380875301050119 2857 17650664
SGTC_2515 chrysin 20.77 µM -0.304077580942616 0.398176080756161 no 2057 0.380534393221942 3014 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_528 3492-0019 172 µM -0.305538581861934 0.397632144119689 no 2058 0.379977994900144 3017 2869262
SGTC_308 4092-1169 104 µM -0.306098719222025 0.39742365538846 no 2059 0.379764741534053 2962 2268590 YDL196W YDL196W
SGTC_1740 st038286 13.222 µM -0.306211226839641 0.397381782459124 no 2060 0.379721912468918 3157 716786
SGTC_1545 lovastatin 49.4 µM -0.306992176293657 0.397091162391329 no 2061 0.379424663647608 3009 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2793 7325131 81.82 µM -0.307529256435963 0.396891328227677 no 2062 0.379220278905941 3011 4176441
SGTC_1594 piperine 70.1 µM -0.30842487794223 0.396558149977086 no 2063 0.378879527090865 2935 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1344 1488-0097 29.1 µM -0.308659856838777 0.396470748473354 no 2064 0.378790141635555 3047 747966
SGTC_1089 terbinafine 2.25 µM -0.309742554620145 0.396068101221861 no 2065 0.37837836960144 3059 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2600 tangeritin 87.95 µM -0.310003081147038 0.395971229875187 no 2066 0.378279306645234 2928 68077 A bioactive flavone.
SGTC_1687 st020778 55.3625 µM -0.310584799998073 0.395754953067452 no 2067 0.37805814197318 2983 4259299
SGTC_882 0843-0131 351 µM -0.310685101562544 0.395717665267327 no 2068 0.378020012188652 2955 5425421
SGTC_1632 st005650 90 µM -0.311403667045282 0.395450561510872 no 2069 0.377746883251119 3067 2759605
SGTC_325 2810-4341 181 µM -0.313443815496096 0.394692469535293 no 2070 0.376971750065159 3058 774970
SGTC_1144 3486-0183 12.5 µM -0.315049883303352 0.39409595638153 no 2071 0.376361889747456 2970 6744069
SGTC_1963 st076565 50.3 µM -0.31568458219369 0.393860289864956 no 2072 0.376120965175776 2976 4914280
SGTC_3340 9146634 11.102 µM -0.316449286423467 0.393576403416244 no 2073 0.375830756155565 3051 4907387
SGTC_2218 6965428 192.983 µM -0.317431538095089 0.393211838326924 no 2074 0.375458089856575 3047 675684
SGTC_3136 9095672 49.47 µM -0.319377053663728 0.392490032155042 no 2075 0.374720304474556 2888 17217380
SGTC_117 lucigenin 22.078 µM -0.319433167305962 0.392469218892974 no 2076 0.374699031645772 3044 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1454 4239-0054 42.6 µM -0.321491839160313 0.391705844460513 no 2077 0.373918847853293 3146 1340767
SGTC_2100 5377183 190 µM -0.321532429163914 0.391690797494624 no 2078 0.37390347046312 3046 2844202
SGTC_2508 celastrol 40.54 µM -0.322213103183342 0.391438491575068 no 2079 0.373645629255014 2999 122724 Celastrol is a natural product and antioxidant.
SGTC_1947 st076332 61.6 µM -0.323608757073461 0.390921306481216 no 2080 0.373117128632833 3069 24208416
SGTC_770 0389-1121 67.2 µM -0.324026581930425 0.390766511303453 no 2081 0.372958954764421 3153 6753108
SGTC_607 4491-0986 66.8 µM -0.32470933764643 0.390513602164873 no 2082 0.372700533439549 3120 698981 YDR232W HEM1
SGTC_687 k029-0044 34.9 µM -0.325605009568164 0.390181893992556 no 2083 0.372361610748872 3111 5829338
SGTC_2409 alverine citrate 63.97 µM -0.326123565874104 0.389989885458705 no 2084 0.372165433946517 3208 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1244 0416-0015 52.5 µM -0.326219806764242 0.389954252796406 no 2085 0.372129028375868 2994 96201
SGTC_2246 7293507 91.5585 µM -0.326405529328491 0.389885492648878 no 2086 0.37205877731166 3134 887656
SGTC_1889 st059080 5.18 µM -0.326454449373616 0.389867381532088 no 2087 0.372040273616861 3152 176925 Isolated from Daphnopsis sellowiana.
SGTC_472 calcifediol 10 µM -0.326481806908097 0.389857253364767 no 2088 0.372029925932907 3026 5283731 A vitamin D metabolite.
SGTC_3158 9100007 49.47 µM -0.328776309022436 0.389008061264504 no 2089 0.3711623855805 2992 19297233
SGTC_324 1315-0088 19.6 µM -0.329421041574172 0.388769541828961 no 2090 0.370918732828372 3056 6787421
SGTC_3099 9120367 49.47 µM -0.329979850407867 0.388562843868411 no 2091 0.370707593614195 2968 24824940
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.333140537730112 0.387394331810542 no 2092 0.36951410034629 3086 1377
SGTC_2662 daunorubicin 22.37 µM -0.335538391327268 0.38650852024973 no 2093 0.368609494701702 2993 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_740 k014-0057 261 µM -0.336529956742464 0.386142390086518 no 2094 0.368235632655416 3093 4012779
SGTC_2855 9016525 58.44 µM -0.340057202909051 0.384840797310748 no 2095 0.366906725152416 2963 43811474
SGTC_16 erodoxin 22.806 µM -0.341062796437556 0.384469959100689 no 2096 0.366528153979481 3116 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_307 1501-1223 22.3 µM -0.341455414526736 0.384325199859462 no 2097 0.366380382070607 3092 2830329
SGTC_341 1486-1430 230 µM -0.341829764803896 0.384187191027705 no 2098 0.36623950417013 2965 2054753 YPL210C SRP72
SGTC_1836 st055642 81 µM -0.343203337401808 0.383680932495763 no 2099 0.365722747056896 3026 8571
SGTC_2111 5486399 200 µM -0.344900947184268 0.383055517690334 no 2100 0.365084419251478 3012 689674
SGTC_3088 9117578 49.47 µM -0.345742376099089 0.382745640508574 no 2101 0.364768167223845 3083 678341
SGTC_2504 purpurogallin 52.29 µM -0.345752428671267 0.382741938851423 no 2102 0.364764389508678 2975 5281571 An antioxidant.
SGTC_19 0279-0214 38.434 µM -0.34809379089861 0.381880071832669 no 2103 0.363884873618566 3028 3566274 YBR002C RER2
SGTC_1287 0971-0001 34.6 µM -0.348442898605305 0.381751613582907 no 2104 0.363753795098675 3048 4665869
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.348806891703986 0.381617691944942 no 2105 0.363617144579596 3165 16725076
SGTC_2147 5545932 89.7195 µM -0.349319433453179 0.381429139785147 no 2106 0.363424755249274 3052 797404
SGTC_1617 st002906 78 µM -0.349523807604052 0.381353963144199 no 2107 0.363348050308919 3000 5150859
SGTC_775 4577-0580 57.3 µM -0.349866423825097 0.381227945818299 no 2108 0.363219473166131 3226 2006902
SGTC_723 4182-0001 115 µM -0.35053422202278 0.380982359842418 no 2109 0.362968905916519 3035 744821 YLR208W SEC13
SGTC_594 1487-1584 10.8 µM -0.350877912588121 0.380855984673029 no 2110 0.362839971248983 3029 5013332
SGTC_2047 4141938 200 µM -0.351002990154167 0.380809996751458 no 2111 0.362793052566691 3046 3807862
SGTC_372 0155-0182 15.9 µM -0.351722436766465 0.380545506776567 no 2112 0.362523216155163 2983 771486
SGTC_1208 2323-2347 50.3 µM -0.353215844152058 0.379996664144321 no 2113 0.361963315278557 3188 5412760
SGTC_2348 9022543 33.42 µM -0.353559991925515 0.379870220496526 no 2114 0.361834330926992 3148 3162678 YDL140C RPO21
SGTC_823 0417-1665 178 µM -0.353622418283604 0.379847285746868 no 2115 0.361810935614348 3098 3429856
SGTC_1798 st045719 60.953 µM -0.353645497427978 0.379838806832907 no 2116 0.361802286453127 3107 3980186
SGTC_425 3825-7017 13.1 µM -0.353675547968143 0.379827766824564 no 2117 0.361791024791054 3250 3397440
SGTC_784 4579-0127 173 µM -0.354606244567961 0.379485894773363 no 2118 0.361442298661228 3225 1948547
SGTC_3105 9121040 49.47 µM -0.354935771143891 0.37936487260252 no 2119 0.361318854707777 3080 41448907
SGTC_2277 7947813 106.88 µM -0.355738756266712 0.379070017216266 no 2120 0.361018108921328 3230 1246798
SGTC_3149 9097855 49.47 µM -0.356708367229782 0.378714070748218 no 2121 0.360655070474905 3166 25236625 YMR079W SEC14
SGTC_317 4495-0002 170 µM -0.356987516887259 0.378611613306964 no 2122 0.360550575468797 3073 15991618
SGTC_717 1532-0246 73.2 µM -0.357677493912714 0.378358404834792 no 2123 0.360292338798703 3091 9561992
SGTC_1375 2910-0797 186 µM -0.358099230858763 0.378203661090148 no 2124 0.360134527313438 3080 742508
SGTC_692 k241-0027 77.8 µM -0.358109030353372 0.378200065691154 no 2125 0.360130860683393 3208 3600480
SGTC_2680 butyl paraben 22.24 µM -0.3581595973204 0.378181513022183 no 2126 0.360111940487621 3095 7184 An antifungal and steroid mimetic.
SGTC_1234 0326-0494 15.5 µM -0.358512736666539 0.378051956481365 no 2127 0.359979819009882 3170 1547813
SGTC_1267 0828-0272 9.49 µM -0.359613013794718 0.377648384829696 no 2128 0.359568275104474 3177 745334
SGTC_2838 9002687 71.43 µM -0.361803987092907 0.376845153814145 no 2129 0.358749256226074 2998 6457060
SGTC_1314 1222-0010 41.1 µM -0.366790572897652 0.375019016508467 no 2130 0.356887620019052 3110 3526027
SGTC_1436 4092-1007 8.32 µM -0.366826029490476 0.375006041922846 no 2131 0.3568743951839 3066 2881121
SGTC_615 k087-0205 167 µM -0.368376890324666 0.374438675992643 no 2132 0.356296113324342 3062 9642773
SGTC_2876 9059903 25.97 µM -0.369699170658471 0.373955148385673 no 2133 0.355803324900864 3132 6916095
SGTC_1111 tnp00062 510.699 nM -0.371472727727786 0.37330691064185 no 2134 0.355142732616282 3213 676306
SGTC_1747 st037496 66.6 µM -0.3735464901219 0.372549402025739 no 2135 0.354370875518603 3063 723305
SGTC_2941 9056145 11.23 µM -0.374532131010021 0.372189537458305 no 2136 0.354004228051433 3105 2119517
SGTC_1808 st050063 61.5 µM -0.376256795599333 0.371560118659977 no 2137 0.353362997717063 3216 4011993
SGTC_2715 st079500 56.4 µM -0.376830604288413 0.371350782375437 no 2138 0.35314974777333 3035 28246688
SGTC_2070 5230947 200 µM -0.380228158714618 0.370112071676564 no 2139 0.351888029255403 3177 2835538
SGTC_2248 tofa 1.1 µM -0.381201304487265 0.369757520934802 no 2140 0.351526940615418 3017 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_74 000s-0487 160.283 µM -0.381449531707126 0.3696671008601 no 2141 0.351434856591548 3141 677548
SGTC_1620 st003704 16.5 µM -0.381459515245548 0.369663464373827 no 2142 0.351431153213946 3209 2834414
SGTC_1937 st074714 47.2 µM -0.381544239218928 0.369632604285136 no 2143 0.351399725559325 3037 17250970
SGTC_3128 9127691 49.47 µM -0.381682828945261 0.369582125799606 no 2144 0.351348319040961 3175 41316314
SGTC_1263 0774-1208 64.8 µM -0.382699635260963 0.369211843600181 no 2145 0.350971242462668 3254 906585
SGTC_1337 1486-1011 40.3 µM -0.383716450545531 0.368841679447008 no 2146 0.350594309264046 3150 X1337
SGTC_2075 5212009 200 µM -0.386505824357628 0.367826853778815 no 2147 0.34956104495063 3212 780898
SGTC_1976 st070609 63.5 µM -0.386952249960163 0.367664521310245 no 2148 0.349395779239619 3034 682556
SGTC_2107 5363541 170.161 µM -0.38836164634504 0.367152181768601 no 2149 0.348874211459415 3193 244052
SGTC_1899 st063254 59.6 µM -0.388542015999793 0.367086631382019 no 2150 0.348807483607504 3049 3093813
SGTC_3164 9100705 49.47 µM -0.388868745865715 0.366967900271822 no 2151 0.34868662162455 3220 17174235
SGTC_1246 0422-0085 105 µM -0.38893546801113 0.366943655523516 no 2152 0.348661942050122 3233 264295
SGTC_1673 st016611 27.3 µM -0.390520642224084 0.366367808886601 no 2153 0.348075797170815 3254 5226799
SGTC_2602 kawain 100 µM -0.391235971592544 0.366108049408724 no 2154 0.34781141078517 3168 5369129
SGTC_558 k064-0027 21.3 µM -0.392691609101395 0.365579649401267 no 2155 0.347273634407073 3174 5088526
SGTC_499 genistein 192 µM -0.393204054800359 0.36539369097836 no 2156 0.347084387564102 3171 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2830 7992007 71.43 µM -0.393356167132433 0.365338497911465 no 2157 0.347028219624869 2942 1952075
SGTC_1483 3453-0561 55.9 µM -0.39634687325115 0.364253905499875 no 2158 0.345924576311045 3180 4546991
SGTC_724 3910-0327 137 µM -0.396487884433679 0.364202793935858 no 2159 0.345872571964998 3182 2885483
SGTC_1604 st002052 72.4 µM -0.396729313814376 0.364115289935955 no 2160 0.345783540549982 3230 6254834 YHR062C RPP1
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.397820473441433 0.363719896942575 no 2161 0.345381262288381 3062 15053
SGTC_2387 9077560 195.08 µM -0.399335556135351 0.363171131695112 no 2162 0.344822985727003 3103 5303272
SGTC_887 0885-0007 9.62 µM -0.399914650331695 0.362961457002581 no 2163 0.344609690660503 3220 5719458
SGTC_819 1013-0258 27.7 µM -0.399987383923463 0.362935124994682 no 2164 0.344582904525675 3121 5753198
SGTC_1072 oxiconazole 14.9 nM -0.400131643404284 0.362882900125252 no 2165 0.344529779331251 3176 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_394 menadione 8.33 µM -0.400898322537146 0.362605389479292 no 2166 0.344247492497825 3218 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_80 0159-0065 512.242 µM -0.402164443543714 0.362147256639547 no 2167 0.343781504040126 3211 1548079
SGTC_2563 tomatine 8.54 µM -0.402261445597959 0.362112165579087 no 2168 0.343745812774585 3319 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_473 2-arachidonoylglycerol 10 µM -0.402748232823569 0.361936084959246 no 2169 0.343566723664273 3061 5282280 An endocannabinoid.
SGTC_1612 st002233 45.4 µM -0.402874264448625 0.361890501574666 no 2170 0.343520362326085 3201 1035021
SGTC_2304 7443016 91.4 µM -0.404258274065408 0.361390059071091 no 2171 0.343011402738426 3089 939854
SGTC_1864 st057645 30.4 µM -0.405364697213351 0.360990159213662 no 2172 0.342604728301252 3219 688666
SGTC_842 0271-0008 11.1 µM -0.407340467914458 0.36027642493713 no 2173 0.341878972243361 3250 1221709
SGTC_769 0302-0231 76 µM -0.40765870913452 0.360161507816984 no 2174 0.341762127841061 3225 571869 YER009W NTF2
SGTC_711 k292-0785 179 µM -0.408069329432743 0.360013251218789 no 2175 0.341611388237161 3108 4146315
SGTC_1353 1498-1206 8.11 µM -0.410714118602217 0.359058841733096 no 2176 0.340641086527159 3183 6756808
SGTC_2790 5423970 71.43 µM -0.412019589883858 0.358588067643179 no 2177 0.340162532337582 3283 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1940 st075990 51.1 µM -0.413185831365478 0.358167683699462 no 2178 0.339735234035339 3373 1084979
SGTC_1415 3966-0071 78.1 µM -0.414451997337836 0.357711475538093 no 2179 0.339271557559624 3204 2893185
SGTC_112 phenothiazine 287.218 µM -0.41683276256403 0.356854220390441 no 2180 0.338400368323755 3277 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1217 1183-1422 255 µM -0.417495892832535 0.356615571888854 no 2181 0.338157863920537 3264 2849664
SGTC_247 mechlorethamine 29.705 µM -0.417714704844679 0.356536837742265 no 2182 0.338077859863889 3124 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2198 6589944 200 µM -0.418978178347402 0.356082327388091 no 2183 0.337616040191862 3197 5290268
SGTC_500 h-89 112 µM -0.419741696850795 0.355807765303944 no 2184 0.337337080463819 3283 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2066 5222451 176 µM -0.420122545167211 0.355670839779139 no 2185 0.337197966824955 3135 2281147
SGTC_3212 9128307 49.47 µM -0.421268249220912 0.355259039750501 no 2186 0.336779606227383 3030 27243542
SGTC_1379 2144-0755 36.5 µM -0.421407865031922 0.35520886922575 no 2187 0.336728638479908 3319 5392327
SGTC_2987 9018338 71.43 µM -0.422622703139463 0.354772426791096 no 2188 0.336285279815655 3275 5055682
SGTC_2642 cholecalciferol 100 µM -0.422730976306316 0.354733537840014 no 2189 0.33624577624882 3225 9821465 A vitamin D precursor, similar to steriods.
SGTC_573 3702-0553 84.7 µM -0.422735640395587 0.354731862652499 no 2190 0.336244074592077 3162 1222756
SGTC_2661 dactinomycin 12.96 µM -0.424467926229724 0.354109877061357 no 2191 0.335612295853571 3175 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1973 st070275 50.2 µM -0.424772394430059 0.354000596436086 no 2192 0.335501301761795 3215 17118334
SGTC_1311 1190-0148 100 µM -0.425137905063026 0.353869422164604 no 2193 0.335368073569056 3289 1961333
SGTC_189 3970-0742 2.116 µM -0.425804670025728 0.353630178579534 no 2194 0.335125091865275 3295 2891807
SGTC_734 2023-0417 80 µM -0.425934447746955 0.353583619431929 no 2195 0.335077806437086 3225 3935732
SGTC_1227 3909-8010 46.6 µM -0.426285011824671 0.35345786176566 no 2196 0.334950089010409 3146 15982272
SGTC_38 0929-0051 58.268 µM -0.427711130665045 0.352946435928004 no 2197 0.334430722584574 3257 1379719
SGTC_295 k015-0027 31 µM -0.427923001061141 0.352870478924153 no 2198 0.334353590256527 3229 3887424
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.42837825704704 0.352707286340893 no 2199 0.334187876018665 3247 616764
SGTC_1254 0550-0035 264 µM -0.432231961006437 0.351326963032135 no 2200 0.332786416128019 3272 15121435
SGTC_1399 3562-5772 25 µM -0.43329131524512 0.350947864970905 no 2201 0.332401573341669 3141 23847490
SGTC_2860 9025725 38.96 µM -0.43393680236069 0.350716945136185 no 2202 0.332167166996679 3112 40546248
SGTC_1469 k284-2957 126 µM -0.436435208356352 0.349823673133268 no 2203 0.331260499276935 3210 23884841
SGTC_2971 9092186 9.93 µM -0.437683648670992 0.349377620721671 no 2204 0.330807812137637 3117 25236400
SGTC_1492 4158-0558 28.5 µM -0.438096467486954 0.349230171338228 no 2205 0.330658177525399 3251 3967268
SGTC_25 0118-0223 35.662 µM -0.440373801312428 0.348417169616824 no 2206 0.329833198300852 3322 5333628
SGTC_1022 4477-0945 21.3 µM -0.44122341816535 0.348114036842494 no 2207 0.32952563060197 3174 4648966
SGTC_398 bronopol 33.3 µM -0.441419354785521 0.34804414284266 no 2208 0.329454716421306 3124 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_3342 9147791 14.508 µM -0.44255413776077 0.347639447606191 no 2209 0.329044131827759 3185 1838168
SGTC_1837 st055472 66.5 µM -0.442951629344483 0.347497732051085 no 2210 0.328900361056582 3354 676091
SGTC_1370 2001-0092 44.6 µM -0.443454640867175 0.347318426586115 no 2211 0.328718460521597 3390 790957
SGTC_1008 4106-0037 6 µM -0.444199617362466 0.347052932115035 no 2212 0.328449134436993 3100 2905394
SGTC_2806 7952793 58.44 µM -0.444534848683361 0.346933486969308 no 2213 0.328327969692074 3302 2972490
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.445661770987744 0.346532068623891 no 2214 0.327920791567138 3251 1241132 A phosphatase inhibitor.
SGTC_677 0929-0063 136 µM -0.446051394655144 0.34639332174809 no 2215 0.327780060782936 3245 1539583
SGTC_471 1-acyl-paf 4 µM -0.446501570335388 0.346233037669755 no 2216 0.327617489264608 3177 16759367
SGTC_2691 st077356 60.2 µM -0.448201958305448 0.345627866863765 no 2217 0.327003724772269 3331 2839272
SGTC_343 4130-2827 29.8 µM -0.449262756991985 0.345250526519964 no 2218 0.32662106034114 3229 1118244
SGTC_2779 methotrexate 400 µM -0.44929872342017 0.345237735471631 no 2219 0.326608089279766 3298 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2566 crystal violet carbinol 226 nM -0.449581626710111 0.345137130321196 no 2220 0.326506069334476 3293 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2393 9031399 185.94 µM -0.450830435477127 0.344693163863162 no 2221 0.326055881876501 3333 1526623 YDL150W RPC53
SGTC_776 4476-4378 112 µM -0.450911229737309 0.344664447894485 no 2222 0.326026764790829 3272 2892008
SGTC_152 4469-0003 551.229 µM -0.453445209659567 0.343764273455125 no 2223 0.325114094105591 3335 697280
SGTC_2881 9058953 51.95 µM -0.454360963268951 0.343439177358225 no 2224 0.324784522127595 3164 17122249
SGTC_3144 9087057 49.47 µM -0.454873535669188 0.343257262687883 no 2225 0.324600111488326 3306 17249618
SGTC_2702 st077768 96.8 µM -0.454893638442183 0.343250128846603 no 2226 0.324592879892799 3254 6484119
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.454933500637753 0.343235983173491 no 2227 0.324578540411195 3367 688751
SGTC_899 1083-0020 478 µM -0.455473527181908 0.343044368641827 no 2228 0.324384304271881 3355 767123
SGTC_99 0109-0120 622.8 µM -0.455846082553526 0.342912200469318 no 2229 0.324250331818272 3385 759414
SGTC_1398 3558-0053 112 µM -0.455848745501538 0.342911255827982 no 2230 0.324249374293016 3129 4532369
SGTC_3356 9151811 4.48 µM -0.460331913252255 0.341322315121135 no 2231 0.322638998902033 3174 1859254 YPR165W RHO1
SGTC_2085 5307070 144.047 µM -0.462622372715596 0.340511604355123 no 2232 0.321817534639819 3174 2840351
SGTC_1965 Pectolinarigenin 58.4 µM -0.463124020208867 0.340334143817882 no 2233 0.321637736760204 3217 5320438 An anti-inflammatory.
SGTC_1455 4262-0120 131 µM -0.464467100721261 0.339859195882407 no 2234 0.3211565625484 3385 1529587
SGTC_164 4100-3994 89.624 µM -0.464632859605389 0.339800596862285 no 2235 0.321097198289037 3369 4615967
SGTC_3202 9113761 49.47 µM -0.465119908919603 0.339628437769695 no 2236 0.320922794748607 3322 4798415
SGTC_1865 st057639 52.2 µM -0.465962308947698 0.339330750554732 no 2237 0.320621239822489 3254 688818
SGTC_2698 st077697 67.5 µM -0.466165356877454 0.339259012489413 no 2238 0.320548572211041 3232 3154499
SGTC_1177 0983-0204 23.6 µM -0.467747829328775 0.338700115187804 no 2239 0.319982466459561 3347 766818
SGTC_890 0929-0006 47.2 µM -0.469344970637122 0.338136397045608 no 2240 0.319411537865701 3218 1378169
SGTC_2744 captopril 92.04 µM -0.470694994004687 0.337660183074834 no 2241 0.318929279887028 3277 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3098 9119039 49.47 µM -0.470783477387566 0.337628980069679 no 2242 0.31889768237062 3317 17161528
SGTC_351 caspofungin 25 nM -0.471869329447394 0.337246153391048 no 2243 0.318510030612617 3249 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3321 9137793 26.8275 µM -0.472096331549473 0.337166143082425 no 2244 0.318429015408137 3315 4904192
SGTC_2222 6885208 172.143 µM -0.473214917258336 0.33677198832627 no 2245 0.318029928118869 3271 609514
SGTC_2478 5763493 32.33 µM -0.474094777076182 0.336462079034972 no 2246 0.317716161461098 3222 1365576 YLR208W SEC13
SGTC_515 4092-1064 102 µM -0.474173077236138 0.336434505080505 no 2247 0.317688245192521 3418 717353
SGTC_2617 dihydrotanshinone i 20.83 µM -0.476208957277 0.335717864704364 no 2248 0.316962759364129 3219 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2523 spermine 47.74 µM -0.477304972117509 0.335332308823346 no 2249 0.316572485450805 3308 1103 A DNA binding polyamine.
SGTC_2053 5265679 138 µM -0.477506306913186 0.335261502147369 no 2250 0.316500815428179 3212 764595
SGTC_2998 9066762 71.4286 µM -0.480702902801483 0.334138088924156 no 2251 0.31536383387986 3422 4945196
SGTC_1716 st033144 30.6155 µM -0.480716293059303 0.334133386160507 no 2252 0.31535907483008 3405 674617
SGTC_1638 st008370 60.6 µM -0.482032435792484 0.333671273673479 no 2253 0.314891452334121 3328 24207134
SGTC_1009 4106-0057 9.87 µM -0.484507094413953 0.332803076602984 no 2254 0.314013015350675 3381 2928005
SGTC_872 0588-0139 234 µM -0.484569890199795 0.332781057272423 no 2255 0.313990738219193 3258 2047100
SGTC_1499 4480-0877 67.3 µM -0.48581844899214 0.332343370188116 no 2256 0.313547946311649 3321 2861909
SGTC_109 0132-0036 33.701 µM -0.486085955422993 0.332249624488635 no 2257 0.313453112093059 3276 67274 A color developer.
SGTC_2797 7859098 81.82 µM -0.486788191755647 0.332003580781303 no 2258 0.313204219626643 3243 972681
SGTC_1906 st060206 94.7 µM -0.488964919498994 0.331241377613914 no 2259 0.312433266525937 3359 5133468
SGTC_3046 9092212 49.47 µM -0.489797324351802 0.330950087148749 no 2260 0.312138662129305 3316 25236637
SGTC_138 0850-0259 40.9225 µM -0.490703424231735 0.3306331242536 no 2261 0.311818112129835 3374 6813004
SGTC_676 falcarinol 140 µM -0.491081833546448 0.330500788780431 no 2262 0.3116842848344 3431 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1733 st037357 54.9 µM -0.491177042293832 0.33046749617421 no 2263 0.3116506174608 3166 1272339 YGL099W LSG1
SGTC_1502 4534-4282 27.7 µM -0.491624308604405 0.330311113996281 no 2264 0.311492477836822 3292 3278949
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.492002088377054 0.330179050172367 no 2265 0.311358933602662 3403 1273210
SGTC_707 0865-0008 204 µM -0.49215633202865 0.330125135932715 no 2266 0.311304415980227 3273 723043
SGTC_2017 5132927 60.65 µM -0.492163457370348 0.330122645429996 no 2267 0.311301897618786 3229 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1907 st060210 83.7 µM -0.492269454715021 0.330085597334321 no 2268 0.311264435247748 3394 688793
SGTC_1268 0828-0275 2.46 µM -0.492828426737536 0.329890253508265 no 2269 0.311066911533325 3346 745337
SGTC_2848 9016370 25.97 µM -0.495915862172152 0.328812124966183 no 2270 0.309976887169686 3417 7894410
SGTC_1512 0259-0544 12.2 µM -0.497609018738527 0.328221480378105 no 2271 0.309379822893907 3309 18476
SGTC_934 2950-0684 338 µM -0.498730197714549 0.327830601839945 no 2272 0.308984733909728 3415 1121253
SGTC_958 1222-0007 33 µM -0.502149095549609 0.326639831218175 no 2273 0.307781323648711 3427 7312461
SGTC_3325 9138760 55.175 µM -0.502160177074285 0.32663597448684 no 2274 0.30777742643796 3262 43844959
SGTC_793 0488-0545 106 µM -0.502944949307153 0.326362895337696 no 2275 0.307501488649908 3250 292548
SGTC_728 3030-5151 22.5 µM -0.503409424463543 0.326201314582417 no 2276 0.307338223446802 3325 3125388
SGTC_1725 st036284 20.55 µM -0.503564554624901 0.326147355454926 no 2277 0.307283702967017 3439 707914
SGTC_1459 k035-0031 35.7 µM -0.503923934212098 0.326022365965362 no 2278 0.307157415409812 3241 3877128 YMR208W ERG12
SGTC_208 k072-0098 12.366 µM -0.504252944729269 0.325907955744192 no 2279 0.307041819727723 3333 5948901
SGTC_813 k007-0158 173 µM -0.504501203971063 0.325821636846182 no 2280 0.306954608168824 3323 6523916
SGTC_2853 9015042 58.44 µM -0.505697355721536 0.325405869857395 no 2281 0.306534562437578 3209 6457456
SGTC_382 3229-0966 23.2 µM -0.508611642124736 0.324393811319711 no 2282 0.30551223344632 3432 5722370
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.508644380196933 0.32438244955504 no 2283 0.305500757549261 3372 4213774
SGTC_2301 7769476 200 µM -0.509960704848324 0.323925753951493 no 2284 0.305039495807943 3324 977820
SGTC_57 miconazole 162.5 nM -0.511473259169323 0.323401304051226 no 2285 0.304509854191493 3337 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2747 doxorubicin 7.63 µM -0.512647335246089 0.322994456822344 no 2286 0.304099017681253 3283 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3027 9089541 49.47 µM -0.513924715305365 0.322552052586101 no 2287 0.303652313505885 3393 9943819
SGTC_296 1222-0039 74.9 µM -0.514028731953863 0.322516038799852 no 2288 0.303615951428616 3329 5984176
SGTC_1054 3429-0080 167 µM -0.514755113820571 0.32226458932899 no 2289 0.303362077502682 3420 1162877
SGTC_2180 6301957 200 µM -0.515698710602248 0.321938068638766 no 2290 0.303032427665761 3383 845462
SGTC_1784 st039334 36.3 µM -0.517462784025757 0.321328000315765 no 2291 0.302416570910403 3476 3496984
SGTC_2447 5741742 33.78 µM -0.517853144775912 0.321193067159258 no 2292 0.302280367710162 3382 1776504
SGTC_349 k015-0014 24 µM -0.518401680212317 0.321003498798481 no 2293 0.302089021322507 3258 2196908
SGTC_588 3970-1144 52.9 µM -0.51879256087678 0.320868442809574 no 2294 0.301952703064697 3377 1888707
SGTC_2312 7706453 155.7 µM -0.519496994322628 0.32062510879816 no 2295 0.301707104179181 3315 976098
SGTC_1637 st007924 17.4 µM -0.519724671247175 0.320546478326254 no 2296 0.301627744423616 3347 683336
SGTC_1119 parthenolide 318.541 nM -0.519772684189643 0.320529897611018 no 2297 0.301611010086352 3471 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1878 temozolomide 1 mM -0.520381882147574 0.320319549242794 no 2298 0.301398717693872 3421 5394 DNA alkylating agent.
SGTC_2470 5664817 21.68 µM -0.521226617009472 0.320027968469505 no 2299 0.301104457109211 3402 2859561
SGTC_2499 avocadenofuran 51.48 µM -0.522217737971587 0.31968600066783 no 2300 0.300759368573518 3263 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3332 9141069 11.198 µM -0.522379011449807 0.319630370750356 no 2301 0.30070323325285 3275 17332883
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.523123393154363 0.319373655206984 no 2302 0.300444193642093 3223 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_855 0428-0020 25 µM -0.523461310210926 0.319257146026508 no 2303 0.300326634153512 3351 6812414
SGTC_1076 itraconazole 331 nM -0.524412607836621 0.318929247484975 no 2304 0.299995794626462 3398 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.526292191980355 0.318281798642644 no 2305 0.299342603602483 3438 368090
SGTC_455 paf C-16 10 µM -0.52689338958579 0.318074824782376 no 2306 0.29913381231111 3356 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2225 6654152 15.4 µM -0.52773187810729 0.317786253815511 no 2307 0.298842722155994 3370 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1717 st033143 58.0435 µM -0.528761142664627 0.317432177373708 no 2308 0.298485578159746 3460 674616
SGTC_290 2043-6722 48.1 µM -0.529627409436345 0.317134303055878 no 2309 0.298185143267732 3407 773758 YLR208W SEC13
SGTC_1539 benzyladenosine 56 µM -0.529767140952137 0.317086266093624 no 2310 0.298136695091199 3335 92208 A nucleotide analog.
SGTC_1895 st058434 18.3 µM -0.530912445441685 0.316692649038355 no 2311 0.297739726528752 3457 5393175
SGTC_2885 9057732 51.95 µM -0.531608853316456 0.316453409698081 no 2312 0.297498465843809 3452 6471414
SGTC_1606 st000094 49.2 µM -0.532430401045083 0.316171279365837 no 2313 0.297213967042585 3458 1242210
SGTC_554 4483-2211 187 µM -0.532544734501807 0.316132024225814 no 2314 0.297174383667889 3385 747107
SGTC_259 usnic acid 108.925 µM -0.53263727265751 0.316100253781232 no 2315 0.29714234780689 3487 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1857 st056007 79.3 µM -0.532982130492735 0.315981868237284 no 2316 0.297022975094607 3424 619834
SGTC_3166 9102297 49.47 µM -0.533330388958839 0.315862334446202 no 2317 0.296902447516908 3365 25237072
SGTC_1846 st056244 14.8 µM -0.533808096654412 0.315698400729843 no 2318 0.296737155712835 3363 5393182
SGTC_1904 st060225 78 µM -0.534314174694698 0.315524770781958 no 2319 0.296562093450038 3406 66595
SGTC_954 1189-0853 2.85 µM -0.536293295665126 0.314846146881359 no 2320 0.295877931692912 3419 2828194
SGTC_2726 cimetidine 79.27 µM -0.537893919870389 0.314297763108643 no 2321 0.295325143131845 3379 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2228 7354201 200 µM -0.539398949362086 0.31378250426194 no 2322 0.294805802920376 3398 753451
SGTC_552 k242-0005 476 µM -0.540860039450908 0.313282635608132 no 2323 0.294302028020678 3441 4088318
SGTC_1150 3909-7983 10.9 µM -0.540916487181189 0.313263330563895 no 2324 0.294282573168812 3343 23965914
SGTC_3243 9134147 49.47 µM -0.543020170720862 0.312544239029584 no 2325 0.293557957316599 3443 24282180
SGTC_1957 st077035 62.4 µM -0.545220153845292 0.311792992614347 no 2326 0.292801055974141 3481 705593
SGTC_3129 9127257 49.47 µM -0.546924196780503 0.311211636524668 no 2327 0.292215405661501 3303 837894
SGTC_2029 5175081 200 µM -0.546951517786959 0.311202319442634 no 2328 0.2922060203409 3421 1380876
SGTC_1308 1187-1617 41.4 µM -0.549134244602712 0.310458351450723 no 2329 0.291456662943986 3403 2882570
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.550088403315874 0.310133375929406 no 2330 0.291129370151474 3443 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2835 9006588 71.43 µM -0.550341277701955 0.310047274650339 no 2331 0.291042658683469 3488 2345538
SGTC_609 0986-0026 86.3 µM -0.551320135018387 0.309714081435643 no 2332 0.290707119046248 3417 2848610
SGTC_1143 3454-2408 5.08 µM -0.551744439905526 0.309569700847205 no 2333 0.290561729044381 3428 X1143
SGTC_85 0868-0259 160.055 µM -0.552452129551905 0.309328956728406 no 2334 0.290319311691529 3380 83173
SGTC_218 alverine citrate 93.75 µM -0.55362666457364 0.30892958029161 no 2335 0.289917186781581 3474 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2683 piperine 63.03 µM -0.555020827196271 0.308455817081043 no 2336 0.289440207408673 3369 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_553 k007-0256 45.7 µM -0.555458666040485 0.308307096777814 no 2337 0.289290487424063 3412 6287000
SGTC_312 4092-0653 6.84 µM -0.55724313569243 0.307701293238908 no 2338 0.288680660766384 3445 1148278
SGTC_131 0141-0277 33.849 µM -0.557987363913965 0.307448792449978 no 2339 0.288426506404938 3451 1547771
SGTC_1928 4'-methoxychalcone 40.3 µM -0.559260256686672 0.307017138511198 no 2340 0.287992057430502 3529 641818
SGTC_2896 9052656 71.43 µM -0.559497749253457 0.306936631372772 no 2341 0.287911033434647 3419 6469436
SGTC_6 0844-0013 19.835 µM -0.560501668994554 0.306596417474525 no 2342 0.287568650788921 3523 1584900
SGTC_628 1636-0253 16 µM -0.563361362462381 0.305628222526932 no 2343 0.28659442076646 3426 4456143
SGTC_1988 st071872 53.4 µM -0.566444591583502 0.304585866531449 no 2344 0.285545794516582 3494 16414116
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.566480780360286 0.304573641483229 no 2345 0.285533497329833 3392 6857784
SGTC_207 4185-0010 4.486 µM -0.56741690337378 0.304257482613392 no 2346 0.2852154841462 3520 3761753
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.567956884999023 0.304075179939874 no 2347 0.285032122141739 3486 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2358 9037157 4 µM -0.568838365886719 0.30377768868331 no 2348 0.284732917776826 3449 2388925
SGTC_3060 1327-0027 12.5 µM -0.569280383759241 0.303628560838422 no 2349 0.284582938445704 3408 16000455 YPR107C YTH1
SGTC_1471 k673-0312 37 µM -0.569770526838589 0.303463234752315 no 2350 0.284416674063537 3453 24099884
SGTC_367 0335-0881 7.1 µM -0.571799067230874 0.30277943270252 no 2351 0.283729054652133 3476 23828853
SGTC_278 4092-0821 23.9 µM -0.572384900996775 0.302582082098496 no 2352 0.283530621374373 3461 877900
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.575433046678627 0.301556180906767 no 2353 0.282499229850406 3648 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_870 0573-2213 57.6 µM -0.576696088931997 0.301131543280857 no 2354 0.282072387472879 3494 3916321
SGTC_2158 5657123 3.6195 µM -0.577251394240711 0.300944933704923 no 2355 0.281884821586582 3461 2858827
SGTC_640 3381-0960 37.1 µM -0.577536344714765 0.300849196742555 no 2356 0.281788596989279 3500 1745025
SGTC_386 1509-0011 3.07 µM -0.579543917731801 0.300175086981612 no 2357 0.281111111028369 3505 3107280
SGTC_3269 9137823 49.47 µM -0.58056908618748 0.299831116045418 no 2358 0.280765456124359 3373 17682936
SGTC_1628 st004252 77.7 µM -0.580849011388362 0.299737224815568 no 2359 0.280671109792529 3489 692968
SGTC_1909 st060837 51.5 µM -0.582660151929972 0.299130062416564 no 2360 0.280061051667824 3402 678937
SGTC_924 2046-0044 21.3 µM -0.582976788556672 0.299023971272133 no 2361 0.279954462956587 3497 3623589
SGTC_82 0054-0107 293.755 µM -0.584263213355296 0.298593122171442 no 2362 0.279521618931311 3503 3104697
SGTC_2753 fluvastatin 17.09 µM -0.585728501448446 0.298102712457692 no 2363 0.279028988882579 3453 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1559 coumarin 343 70.1 µM -0.585949218782659 0.29802887352404 no 2364 0.278954820293513 3530 108770 A hepatotoxic, DNA x-linker.
SGTC_1929 genistein trimethyl ether 50.5 µM -0.586634722846247 0.297799597669361 no 2365 0.278724528598787 3542 136420
SGTC_1294 1000-1494 117 µM -0.586652325415848 0.297793711317879 no 2366 0.27871861632173 3446 712797 YDL207W GLE1
SGTC_2295 7971645 200 µM -0.588051064112342 0.297326138706407 no 2367 0.278249009128972 3443 2978226 YKL099C UTP11
SGTC_1647 st011722 22.4 µM -0.588515594404299 0.297170929004497 no 2368 0.27809313487882 3516 2854783
SGTC_1797 st048695 56.8 µM -0.590023361676271 0.296667406473462 no 2369 0.277587493665187 3488 592262 YIL048W NEO1
SGTC_2006 4011487 200 µM -0.59009718686506 0.296642762409715 no 2370 0.277562747367538 3542 45595294
SGTC_22 0964-0034 14.468 µM -0.59069247732763 0.296444078921767 no 2371 0.277363244644189 3490 138402
SGTC_393 acivicin 6.25 µM -0.592760978094437 0.295754173033922 no 2372 0.276670563040412 3422 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_3291 9121177 71.43 µM -0.593053298411009 0.295656735127604 no 2373 0.276572741754298 3444 17015612
SGTC_2040 5100729 123 µM -0.593865267274357 0.295386162390041 no 2374 0.276301115655838 3467 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2240 6690706 185.951 µM -0.594057921583118 0.295321980836212 no 2375 0.276236686664071 3422 805876
SGTC_1067 clotrimazole 1.36 µM -0.597916678178298 0.294037814454401 no 2376 0.274947765396407 3490 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_808 0711-0032 135 µM -0.598684072711989 0.293782739126601 no 2377 0.274691790126971 3497 4252555
SGTC_1175 0741-0056 27.6 µM -0.599638176199215 0.293465746205688 no 2378 0.274373699428099 3574 765927
SGTC_2367 9070478 135.38 µM -0.600042181734211 0.293331566502001 no 2379 0.274239061936316 3497 572802
SGTC_2476 5806916 10.51 µM -0.600371660752346 0.293222159852954 no 2380 0.274129285053953 3444 2870194
SGTC_2825 7998094 58.44 µM -0.601445814017018 0.292865608460911 no 2381 0.273771546025357 3469 2987815
SGTC_546 peri-Naphthalide 147 µM -0.601675887731131 0.29278926462112 no 2382 0.273694951661859 3430 223824 A penicillin ester.
SGTC_313 3474-0040 5.03 µM -0.603196242128619 0.292285007905043 no 2383 0.273189073657467 3494 1043375 YIL048W NEO1
SGTC_1924 st058459 75.1 µM -0.605037255456513 0.291674939366267 no 2384 0.272577121396373 3499 688683
SGTC_526 4469-0568 170 µM -0.605826103360807 0.291413715485168 no 2385 0.272315117015845 3543 2901964
SGTC_1994 st072947 40.9 µM -0.606348202229663 0.291240884545695 no 2386 0.272141778293114 3549 5286565 YDL195W SEC31
SGTC_772 k072-0172 35.3 µM -0.607453022176809 0.29087531268257 no 2387 0.271775154984079 3460 5861980
SGTC_1301 naphtanilide LB 4.81 µM -0.608230561674769 0.290618162710178 no 2388 0.271517283825998 3575 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2316 5844804 197.44 µM -0.608526821359803 0.290520210892647 no 2389 0.271419061304487 3536 776813
SGTC_3265 9137266 49.47 µM -0.608712144469412 0.290458945695852 no 2390 0.271357627916326 3494 17224265
SGTC_5 0352-0601 109.883 µM -0.609155750177029 0.290312320496709 no 2391 0.271210603700383 3459 762456
SGTC_507 nimesulide 162 µM -0.609798419115911 0.290099960343948 no 2392 0.27099767443573 3584 4495 A COX2 inhibitor.
SGTC_163 TUB2.036 7.546 µM -0.610123843026184 0.289992456746955 no 2393 0.270889886704121 3520 15992207 YJR013W GPI14
SGTC_175 3793-3120 23.7 µM -0.611025681780081 0.289694632490272 no 2394 0.270591289233492 3482 5322297
SGTC_2213 7173844 200 µM -0.611082171513422 0.289675982034897 no 2395 0.270572591039768 3504 892728
SGTC_2226 7298446 200 µM -0.612801083641707 0.28910874160328 no 2396 0.270003937134536 3535 3283010
SGTC_1296 1068-0102 11.9 µM -0.613739992330613 0.288799122793822 no 2397 0.269693578256473 3508 767053
SGTC_182 3448-4371 550.524 µM -0.613830285701327 0.288769355469851 no 2398 0.269663740952798 3558 3491403
SGTC_414 piperonyl butoxide 100 µM -0.613922344797946 0.288739007520271 no 2399 0.269633321870253 3468 5794 A potent inhibitor of cytochrome P450.
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.61610154986782 0.288021055670592 no 2400 0.268913749620053 3584 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2059 5238311 157 µM -0.61674569892123 0.287808998463755 no 2401 0.268701236747672 3508 703021
SGTC_2927 9011802 47.9 µM -0.618736605990252 0.287154048188993 no 2402 0.268044945328796 3527 43912568
SGTC_192 3455-0609 60.9 µM -0.620229481940927 0.286663398978254 no 2403 0.267553357069148 3596 3769639
SGTC_1992 st073643 23.3 µM -0.620569917909752 0.286551566845786 no 2404 0.267441318785917 3536 3161292
SGTC_841 0251-0215 91.2 µM -0.622541888471507 0.2859041882788 no 2405 0.266792804453813 3532 3888614
SGTC_3016 9080866 49.47 µM -0.623588663347895 0.285560825113735 no 2406 0.266448878824612 3546 17066299
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.624148994368281 0.285377105982424 no 2407 0.26626487012851 3610 165506
SGTC_619 1652-1634 108 µM -0.624708450374569 0.285193729927244 no 2408 0.266081212972234 3492 5400454
SGTC_2714 st079313 56.9 µM -0.625625653920984 0.284893214493319 no 2409 0.265780254002753 3557 2939799
SGTC_563 tetrahydrosecaminediol 614 µM -0.626271109906495 0.284681825873898 no 2410 0.265568566151658 3596 334274 A psychoactive constituent of the cannabis plant.
SGTC_155 k072-0202 43.6 µM -0.627440221427055 0.284299129365867 no 2411 0.265185354759522 3521 5857737
SGTC_2001 4023502 57.655 µM -0.627463013055784 0.284291671207297 no 2412 0.265177886910503 3548 108941 YCR052W RSC6
SGTC_3047 9092122 49.47 µM -0.628182887414264 0.284056153157719 no 2413 0.264942069618217 3510 17173831
SGTC_1704 st028805 70.8 µM -0.62821324343933 0.284046223765042 no 2414 0.264932127897865 3533 2876101
SGTC_2810 7959871 45.46 µM -0.629399647886846 0.28365828345412 no 2415 0.264543724223027 3534 2974535
SGTC_2724 maprotiline 69.64 µM -0.629895824381804 0.283496114870767 no 2416 0.264381372514076 3562 4011 A tricyclic antidepressant.
SGTC_7 0192-1582 4.227 µM -0.630202875641241 0.283395781576785 no 2417 0.264280929044727 3602 252616
SGTC_1474 0330-0125 5.35 µM -0.633919832170046 0.282182566392428 no 2418 0.263066571047771 3573 X1474
SGTC_282 k297-0036 65.7 µM -0.635295752267181 0.281734100722026 no 2419 0.262617771726193 3578 5061378
SGTC_1737 st035557 69.7 µM -0.636686038252923 0.281281301920948 no 2420 0.262164684817044 3496 5716916
SGTC_3219 9131112 49.47 µM -0.637464455033187 0.281027934802739 no 2421 0.261911177901003 3522 17612988 YMR079W SEC14
SGTC_2568 diosmetin 100 µM -0.637530158946482 0.281006553863431 no 2422 0.261889785868382 3577 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1225 1216-0074 20.6 µM -0.637695937160881 0.280952610891052 no 2423 0.261835815395216 3549 4241466
SGTC_2634 4'-methoxyflavone 100 µM -0.638642152054431 0.280644815587126 no 2424 0.26152787652702 3533 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_3290 9121031 71.43 µM -0.639062236122778 0.280508218278321 no 2425 0.261391222790807 3529 17014854
SGTC_960 1222-0186 7.7 µM -0.641290752351411 0.279784117869139 no 2426 0.260666898181387 3582 3126296
SGTC_2895 9054447 58.44 µM -0.643372669594797 0.27910847146977 no 2427 0.259991156518831 3595 2697450
SGTC_1831 st055328 12 µM -0.643862062087215 0.278949763736416 no 2428 0.259832442395947 3596 1103068
SGTC_2919 7978188 46.38 µM -0.644115490019869 0.278867595480485 no 2429 0.25975027322465 3587 2980291
SGTC_2787 5284540 71.43 µM -0.644270406246984 0.278817373210138 no 2430 0.259700051198942 3582 736958
SGTC_1820 st053765 18.6 µM -0.644375764508568 0.278783219644798 no 2431 0.259665898148567 3567 3690829
SGTC_837 0091-0265 12.5 µM -0.645236236164969 0.278504360248332 no 2432 0.259387053520982 3547 759367
SGTC_2584 androsterone 48.74 µM -0.645761559540663 0.278334181656725 no 2433 0.259216893197286 3648 2754130 A steroid.
SGTC_3261 9137475 49.47 µM -0.646636950784592 0.278050711177137 no 2434 0.258933468737508 3472 17027690
SGTC_2586 curcumin 80 µM -0.646683355922997 0.278035688129058 no 2435 0.25891844867235 3595 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3011 9081274 71.4286 µM -0.649780510332794 0.277033921710749 no 2436 0.257917004958089 3575 6625322
SGTC_2912 7964298 10.93 µM -0.650396474547682 0.276834900533234 no 2437 0.257718076987414 3608 2975850
SGTC_2205 7238770 200 µM -0.650397323629568 0.276834626238887 no 2438 0.257717802828193 3612 279867
SGTC_825 1988-2224 89.6 µM -0.65208329467722 0.276290239084869 no 2439 0.257173720053491 3602 1180859
SGTC_3245 9134821 49.47 µM -0.652129814932614 0.276275225499684 no 2440 0.257158715888856 3536 17014901
SGTC_933 2914-0560 114 µM -0.652133392953535 0.276274070773636 no 2441 0.257157561889644 3624 463887
SGTC_3097 9117246 49.47 µM -0.653549836304119 0.27581713155195 no 2442 0.256700935897507 3625 16423892
SGTC_191 3914-0123 66.505 µM -0.653659665062747 0.275781716732846 no 2443 0.256665547490015 3505 3144412
SGTC_3074 9116018 49.47 µM -0.655338801164219 0.275240549524997 no 2444 0.256124822133292 3634 17027303
SGTC_1120 ficusin 1.78878 µM -0.655722480896215 0.27511696715485 no 2445 0.256001350748645 3631 6199 A DNA cross-linker.
SGTC_743 1275-0778 158 µM -0.656395573553315 0.274900231579481 no 2446 0.255784818881206 3595 2849257 YMR203W TOM40
SGTC_805 3852-0218 479 µM -0.657143091455084 0.274659629759753 no 2447 0.255544456734815 3572 6615355
SGTC_2184 6075246 200 µM -0.659452302858177 0.273917025950024 no 2448 0.254802682617184 3613 2267320
SGTC_44 0929-0055 61.211 µM -0.661271083189333 0.273332836146083 no 2449 0.254219241219674 3550 1379590
SGTC_2531 methyl deoxycholate 70.07 µM -0.661408566290003 0.273288701855297 no 2450 0.25417516690012 3592 16667744 Haematoxylin.
SGTC_400 oxethazaine 37.5 µM -0.66203835914715 0.273086573330187 no 2451 0.253973319199826 3580 4621 A local anesthetic.
SGTC_2150 5556613 200 µM -0.662927810479314 0.272801235132506 no 2452 0.253688394674614 3622 743190
SGTC_1260 0700-1617 7.75 µM -0.663515041914195 0.272612930920152 no 2453 0.253500374524594 3613 2853078
SGTC_2076 5212012 200 µM -0.664402712495767 0.272328409099859 no 2454 0.253216298623282 3523 604802
SGTC_3233 9132340 49.47 µM -0.664812319556596 0.272197169001911 no 2455 0.253085270995555 3576 17682950
SGTC_2067 5224629 34.075 µM -0.664816176760566 0.272195933284384 no 2456 0.253084037298946 3611 2835000
SGTC_1697 st025554 27.742 µM -0.667589313254815 0.271308236533548 no 2457 0.25219789060397 3602 1269519
SGTC_487 nimodipine 119 µM -0.667717882471652 0.271267115820557 no 2458 0.252156846458149 3529 4497 L-type voltage-gated calcium channels inhibitor
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.668028034637239 0.271167931627372 no 2459 0.252057848685244 3601 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1611 st001856 99.4 µM -0.670555596436974 0.270360312228146 no 2460 0.251251838842557 3588 647478
SGTC_2315 7733312 200 µM -0.671433769745659 0.270079995529327 no 2461 0.250972119016436 3610 726316
SGTC_1418 3966-3099 2.4 µM -0.672373870994228 0.269780072398813 no 2462 0.250672856354616 3631 740335
SGTC_1114 scopoletin 1.73284 µM -0.67238791616764 0.269775592792663 no 2463 0.250668386784464 3643 5280460 A coumarin with genotoxic properties.
SGTC_624 k048-0052 28 µM -0.672854464151919 0.269626811870051 no 2464 0.250519942053888 3591 6835531
SGTC_268 camptothecin 39.6153 µM -0.673464166441219 0.269432441399294 no 2465 0.250326019181667 3646 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_614 0462-0418 107 µM -0.67444546934713 0.269119753820102 no 2466 0.250014071626548 3512 5188303
SGTC_385 1494-0393 12.4 µM -0.675487764175572 0.268787830983527 no 2467 0.249682961310046 3651 3090647
SGTC_2082 5219693 150 µM -0.677079150485687 0.268281444793017 no 2468 0.249177868315117 3643 2834649
SGTC_1157 4092-0394 27.6 µM -0.678787498001082 0.267738375681001 no 2469 0.248636258186874 3727 3659885
SGTC_1644 st010134 20.9 µM -0.680072965449197 0.267330102083473 no 2470 0.248229130682937 3632 3818134
SGTC_358 0075-0058 9.45 µM -0.681703656463053 0.266812635383168 no 2471 0.247713177464095 3650 1069125
SGTC_584 0986-0246 15.4 µM -0.682866155693517 0.266444049124298 no 2472 0.247345710814306 3733 53315 YDR232W HEM1
SGTC_2439 5492030 7.2 µM -0.690179093760273 0.264131304566465 no 2473 0.245040784406077 3638 5722370
SGTC_1131 3454-3128 32.3 µM -0.691186355488606 0.263813557353599 no 2474 0.244724218675503 3714 710982
SGTC_1151 3909-8316 15.3 µM -0.693001468620204 0.263241460689301 no 2475 0.244154314929483 3683 800431
SGTC_2241 6772625 37.8075 µM -0.693948396030228 0.262943254975626 no 2476 0.243857285820452 3605 2285411
SGTC_2115 tiliquinol 12.7705 µM -0.695878108310962 0.262336086365454 no 2477 0.2432525840676 3664 71208 A bioactive hydroxyquinoline.
SGTC_430 0958-0115 16.4 µM -0.697603536134003 0.261793802927831 no 2478 0.242712584775644 3660 6833180
SGTC_1409 3909-8004 61.9 µM -0.698127501073083 0.261629240270301 no 2479 0.242548730398057 3689 2119279
SGTC_1686 st019653 115.5 µM -0.700777103300204 0.260797888477289 no 2480 0.241721064671809 3678 97252
SGTC_3344 9148862 3.898 µM -0.70165300565122 0.260523360402379 no 2481 0.241447793450264 3694 4905352
SGTC_797 k781-0471 270 µM -0.702632727696293 0.260216469221324 no 2482 0.241142330636743 3682 23738129
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.702977606683272 0.260108482606595 no 2483 0.241034852493751 3698 4174840
SGTC_2982 9019404 25.97 µM -0.703384646585039 0.259981062237211 no 2484 0.240908036035026 3565 22333232
SGTC_1304 1165-0502 251 µM -0.704114490005166 0.259752671613417 no 2485 0.240680738531799 3695 767425
SGTC_1445 4239-0156 97.7 µM -0.705394212738862 0.259352456801482 no 2486 0.240282472260994 3740 4008346
SGTC_344 k064-0035 6.43 µM -0.706388203779434 0.259041820428357 no 2487 0.239973377332925 3663 5088750
SGTC_2765 myclobutanil 7.74 µM -0.707122733991505 0.258812392950007 no 2488 0.239745104639803 3704 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1943 st076331 65.2 µM -0.707207819491121 0.258785823642798 no 2489 0.239718669961214 3740 24208415
SGTC_3072 9116419 49.47 µM -0.709583957625369 0.25804440707507 no 2490 0.238981085357719 3675 17170162
SGTC_333 3486-0131 40.1 µM -0.712278350903681 0.257205021490659 no 2491 0.238146213630047 3759 6744690
SGTC_1912 st060209 90.8 µM -0.712297252079777 0.25719913821647 no 2492 0.238140362653033 3697 688787
SGTC_2045 5106652 78.05 µM -0.714160029678605 0.256619664193542 no 2493 0.237564114819808 3675 673349
SGTC_254 nsc-64875 3.808 µM -0.714343726227573 0.256562556608279 no 2494 0.237507330013274 3701 56993
SGTC_314 1671-0008 2.74 µM -0.715585962722139 0.256176543917964 no 2495 0.237123521897337 3635 3913060
SGTC_3133 9127736 49.47 µM -0.716357512756708 0.255936944932064 no 2496 0.236885311283745 3694 27243420
SGTC_836 0330-0104 1.35 µM -0.71649847073667 0.255893184141339 no 2497 0.236841805722953 3704 46494820
SGTC_1941 st076221 61.8 µM -0.717800412659635 0.255489177373273 no 2498 0.236440179449821 3688 2828568
SGTC_811 0416-0114 265 µM -0.718546319933557 0.255257864463887 no 2499 0.236210249140897 3724 6612453
SGTC_3280 9140961 49.47 µM -0.718591549869234 0.255243841754216 no 2500 0.236196310708144 3713 4901226
SGTC_843 0310-0051 143 µM -0.718925422572007 0.255140343124315 no 2501 0.236093435737391 3720 2065037
SGTC_2752 diclazuril 33.15 µM -0.720392754552679 0.254685738925725 no 2502 0.235641604892311 3753 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.722034872566488 0.254177486489033 no 2503 0.235136518802375 3711 521171
SGTC_538 2922-0838 53.3 µM -0.725949672993755 0.252967964380575 no 2504 0.23393481172651 3728 777039
SGTC_3211 9128781 49.47 µM -0.72599486746513 0.252954018740802 no 2505 0.233920958497281 3742 17194361
SGTC_2818 7996756 12.99 µM -0.728287724817228 0.252247043933535 no 2506 0.233218737474282 3728 2241621
SGTC_2294 7971431 200 µM -0.728356292886535 0.252225917855998 no 2507 0.233197755536609 3664 5741572
SGTC_1117 retinoic acid 1.10837 µM -0.729236095963613 0.251954930063725 no 2508 0.232928627399706 3730 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1137 ixabepilone 100 µM -0.730333875932307 0.251617018882166 no 2509 0.232593063100595 3737 154225 A novel microtubule stabilizer.
SGTC_1203 3992-3522 103 µM -0.730941436808447 0.251430106575659 no 2510 0.232407462297938 3830 5322312
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.73327084316866 0.250714159841908 no 2511 0.231696627255648 3770 65057 A dermal irritant. YDR527W RBA50
SGTC_1389 3405-0187 19 µM -0.733695675890644 0.250583703334701 no 2512 0.23156711725368 3696 799890
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.733700132374245 0.25058233504014 no 2513 0.231565758911211 3752 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1327 1436-0082 2.18 µM -0.7345102883262 0.250333654929228 no 2514 0.231318896044569 3741 15992205
SGTC_2216 7189485 200 µM -0.734640046176695 0.250293837477014 no 2515 0.231279371132702 3721 731273
SGTC_1167 k781-0610 148 µM -0.73540231026938 0.250059997182265 no 2516 0.231047257635663 3748 4525169
SGTC_2567 aureobasidin a 60 nM -0.7354944236997 0.25003174733167 no 2517 0.231019217411059 3845 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_978 1416-0512 87.4 µM -0.735703563766042 0.249967613399724 no 2518 0.230955560192578 3787 6814003
SGTC_1477 0139-0234 16 µM -0.736540843078295 0.249710944632039 no 2519 0.230700810561114 3733 620880
SGTC_2159 5658611 73.75 µM -0.738178782084335 0.249209237866301 no 2520 0.23020290735343 3730 793844
SGTC_3311 9131146 2.8755 µM -0.738583471643618 0.249085362595789 no 2521 0.230079981866766 3744 4900406 YPR165W RHO1
SGTC_2120 5538279 151.968 µM -0.738910633320874 0.248985242521061 no 2522 0.229980632525795 3737 2058197
SGTC_1974 st069448 26.9 µM -0.739333285185869 0.248855931647644 no 2523 0.229852321185824 3701 6323587 YNR016C ACC1
SGTC_1447 4239-0816 81.9 µM -0.743302473779937 0.24764329968656 no 2524 0.228649287111165 3753 1341554
SGTC_1233 0325-0408 14.2 µM -0.743695800534932 0.24752330602399 no 2525 0.228530265309393 3786 12874
SGTC_902 1120-0002 2.07 µM -0.746513871215723 0.246664496034334 no 2526 0.22767852772025 3743 3280475
SGTC_3031 9088762 49.47 µM -0.746766223321324 0.246587669390237 no 2527 0.227602343744982 3722 205253
SGTC_2385 9074692 200 µM -0.746803534692609 0.246576311319999 no 2528 0.2275910808265 3760 17046906
SGTC_3085 9117376 49.47 µM -0.747830130153121 0.246263912176092 no 2529 0.22728131288181 3837 16480349
SGTC_1914 st062367 72.6 µM -0.749289263511407 0.245820254559598 no 2530 0.226841438774521 3765 978205
SGTC_303 1348-1668 34.2 µM -0.751419117896229 0.245173431449428 no 2531 0.226200230342591 3766 5380509
SGTC_1513 0337-0559 19 µM -0.752414193595485 0.24487154732244 no 2532 0.225901006798189 3737 775073
SGTC_781 4335-2806 94.4 µM -0.753393307241558 0.244574701102927 no 2533 0.225606801698995 3888 845254
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.754448929519816 0.244254876367327 no 2534 0.225289850242007 3773 165521
SGTC_986 1493-0483 84 µM -0.754730616716268 0.244169570960028 no 2535 0.22520531607251 3686 40079
SGTC_587 k089-0003 57 µM -0.758494077874371 0.243031396925638 no 2536 0.224077628491867 3687 9659696
SGTC_3257 9139206 32.98 µM -0.759462934173884 0.242738853312751 no 2537 0.223787839348383 3765 4910041
SGTC_1077 5-fluorocytosine 377 nM -0.760244965210182 0.242502860190887 no 2538 0.223554085911404 3801 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2836 9010338 19.48 µM -0.760424336614463 0.242448748896278 no 2539 0.223500490384247 3744 2994051
SGTC_2992 9074591 71.4286 µM -0.761417494317735 0.242149259627052 no 2540 0.223203870758642 3753 17741321
SGTC_249 wiskostatin 11.211 µM -0.761680003680372 0.242070132777763 no 2541 0.223125506341165 3764 2775510 A n-wasp and actin depolymerizer.
SGTC_3056 9094900 49.47 µM -0.762748993749765 0.241748057441474 no 2542 0.222806552754078 3758 25236784
SGTC_1336 1486-0901 104 µM -0.766195832381804 0.240711147438082 no 2543 0.221779893900322 3801 5006114
SGTC_3295 9122362 53.5725 µM -0.766435866313891 0.240639028463394 no 2544 0.22170849933344 3810 4730473
SGTC_637 1181-0519 7.26 µM -0.766585199542144 0.240594166745546 no 2545 0.221664088985324 3788 6252091 YGR060W ERG25
SGTC_729 4092-0585 94.1 µM -0.769960184077839 0.239581491115248 no 2546 0.220661755717351 3780 2169061
SGTC_1451 4152-0210 104 µM -0.770632010345146 0.239380185397727 no 2547 0.220462541005567 3759 659563
SGTC_918 glabranin 770.725 nM -0.770664770652551 0.239370371476937 no 2548 0.220452829322133 3824 124049 Also referred to as licorice root.
SGTC_1760 st045453 10.4495 µM -0.771544713465443 0.239106851519657 no 2549 0.220192064975734 3836 3323419 YIL048W NEO1
SGTC_2741 miltefosine 3.04 µM -0.771781661891048 0.239035918743922 no 2550 0.220121877356436 3747 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1317 1273-0028 910 nM -0.77215913812594 0.238922941389715 no 2551 0.220010089836285 3764 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1496 4469-0713 57.4 µM -0.772494860380662 0.238822485398462 no 2552 0.219910694900624 3753 746691
SGTC_3329 9141233 27.5565 µM -0.772908173844937 0.238698844029109 no 2553 0.21978836347742 3773 4909101 YNL103W MET4
SGTC_3247 9135149 49.47 µM -0.773441790285117 0.238539266231752 no 2554 0.21963048288713 3775 8934436 YOR116C RPO31
SGTC_1956 st077085 54 µM -0.7760124356815 0.237771334594606 no 2555 0.218870821659885 3840 24208685
SGTC_162 k030-0015 37.8 µM -0.776073758282446 0.237753032203298 no 2556 0.218852718463988 3860 1809920 YMR134W ERG29
SGTC_1921 5740136 50 µM -0.776979947208617 0.237482660456285 no 2557 0.218585300648107 3738 1774243
SGTC_2351 9026858 72.31 µM -0.777082285329643 0.237452137326693 no 2558 0.21855511233 3737 1409300
SGTC_909 3448-9333 149 µM -0.78032461493928 0.236486203487056 no 2559 0.217599913871832 3741 3344074
SGTC_2272 7805186 180 µM -0.780707304671439 0.23637233789754 no 2560 0.217487331691734 3790 2956062 YPR165W RHO1
SGTC_1278 0874-0585 172 µM -0.780779106142779 0.236350977434714 no 2561 0.217466212409812 3859 766306
SGTC_1079 idarubicin 2.36 µM -0.78148110544956 0.236142193281602 no 2562 0.217259792652129 3755 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2459 5811157 9.22 µM -0.781817329707659 0.236042231602626 no 2563 0.21716096750604 3790 2870684 YBR192W RIM2
SGTC_3120 9124077 49.47 µM -0.782436907624489 0.235858088104943 no 2564 0.216978925308903 3848 18774327 YGL155W CDC43
SGTC_2623 humulene 100 µM -0.784922831943029 0.235120048476084 no 2565 0.216249407247084 3761 6187145 An anti-inflammatory.
SGTC_1954 st077032 68.9 µM -0.785297894742292 0.235008807901947 no 2566 0.216139464934202 3712 698907
SGTC_3208 9114115 49.47 µM -0.785722372364659 0.234882946377414 no 2567 0.216015076690971 3835 650895
SGTC_983 1491-0821 12.2 µM -0.789168642469086 0.233862475773596 no 2568 0.215006723413171 3817 46495113
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.79023762479412 0.233546440724204 no 2569 0.21469450333871 3820 688761
SGTC_1780 st038448 24.544 µM -0.790638733606332 0.23342791763463 no 2570 0.214577418598333 3887 728868 YDL195W SEC31
SGTC_1435 4092-0789 56.7 µM -0.793619330917179 0.232548231080252 no 2571 0.213708537642265 3811 2248285
SGTC_424 splitomicin 100 mM -0.793749498781869 0.232509855692153 no 2572 0.213670638864005 3915 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2556 citropten 84.59 µM -0.793785460952485 0.232499254139758 no 2573 0.213660169056593 3857 2775 A potential DNA crosslinker.
SGTC_479 n-linoleoylglycine 10 µM -0.79438749135162 0.232321817098256 no 2574 0.213484941975965 3849 6433346 An anti-infammatory.
SGTC_3024 9090631 49.47 µM -0.795741322529683 0.231923076365012 no 2575 0.213091201699575 3757 25236383
SGTC_2630 antimycin a 100 µM -0.796054132828786 0.231830999312756 no 2576 0.213000286081494 3824 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2350 9023895 38.85 µM -0.804040345186628 0.229487131663897 no 2577 0.210686837468 3863 2997209
SGTC_2411 st077133 39.94 µM -0.804144868266999 0.229456543553989 no 2578 0.210656657242705 3963 1403142 YNL221C POP1
SGTC_2046 4110841 106 µM -0.804934666918212 0.229225487157466 no 2579 0.210428691040984 3866 44119630 YMR134W ERG29
SGTC_2458 5808907 16.39 µM -0.805426371855272 0.229081704301265 no 2580 0.210286839298663 3927 2731747
SGTC_1739 st037196 92.5 µM -0.80578312026454 0.228977416697089 no 2581 0.210183956263823 3865 612214
SGTC_2363 9053361 176 µM -0.806135008869744 0.228874575852524 no 2582 0.210082503721976 3890 6469797 YMR079W SEC14
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.806239769576698 0.228843964127576 no 2583 0.210052305858341 3831 16486 A toxic proline analog.
SGTC_216 k038-0035 28.382 µM -0.806329516600346 0.228817741321276 no 2584 0.210026437801835 3754 4444231 YPR107C YTH1
SGTC_1883 5-benzylidenerhodanine 20 µM -0.80670596251769 0.228707767545195 no 2585 0.209917954048415 3853 1273210
SGTC_860 0443-0016 25.1 µM -0.807158368601439 0.228575642267727 no 2586 0.209787623761657 3864 5337942
SGTC_121 0557-0495 61.343 µM -0.807709398907539 0.228414771693706 no 2587 0.209628945834311 3982 3104427
SGTC_2673 kobusone 100 µM -0.808530690619681 0.2281751177541 no 2588 0.209392572894017 3879 6710676 An epoxy ketone and protein crosslinker.
SGTC_693 4161-2696 114 µM -0.809843317696254 0.227792385242617 no 2589 0.209015116349505 3883 805759
SGTC_649 1123-0311 367 µM -0.810440108439549 0.227618494038767 no 2590 0.208843636939302 3801 693629 YIL048W NEO1
SGTC_2432 5630864 12.22 µM -0.811252329921254 0.227381951355658 no 2591 0.208610389764931 3869 5714970
SGTC_1996 st072960 66.8 µM -0.813008919398913 0.226870854964641 no 2592 0.208106472166987 3811 1719405
SGTC_3316 9136639 10.545 µM -0.814504678043317 0.226436161093597 no 2593 0.207677946694005 3888 4903665
SGTC_362 0310-0100 9.03 µM -0.816316308354432 0.225910299708455 no 2594 0.207159624664342 3938 790235
SGTC_530 4358-1714 28 µM -0.817852285272062 0.225464993591945 no 2595 0.206720769276527 3907 1564641
SGTC_962 1254-0300 21.5 µM -0.819855655693692 0.224884929450419 no 2596 0.206149199396118 3817 7340576
SGTC_2276 7947513 42.08 µM -0.820223656828207 0.224778468932447 no 2597 0.206044309103984 3783 2105100
SGTC_3175 9106517 49.47 µM -0.820598982729377 0.224669918846294 no 2598 0.205937363662003 3899 41468073
SGTC_2098 5376439 882.5 nM -0.823500013451199 0.223831899397572 no 2599 0.205111854767005 3890 2844116
SGTC_1927 st060202 13.8 µM -0.823774490103613 0.223752703552912 no 2600 0.205033852451914 3778 688887
SGTC_3154 9100113 49.47 µM -0.827924279350208 0.222557290934338 no 2601 0.203856691949683 3899 25237525
SGTC_3282 9108498 15.4605 µM -0.830184208356046 0.221907817060226 no 2602 0.203217321123283 3877 16459645
SGTC_1452 4194-0072 190 µM -0.83144412022041 0.221546205381872 no 2603 0.202861391719539 3888 1343545
SGTC_2130 NSC 7 2.4545 µM -0.831445500280379 0.221545809470827 no 2604 0.202861002052174 3938 21448
SGTC_45 0kpi-0036 14.9 µM -0.831751538805103 0.221458023251569 no 2605 0.202774601470463 3902 2795021
SGTC_2592 piperlongumine 83.33 µM -0.833122620186125 0.221064976938959 no 2606 0.202387788717385 3907 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1618 st003135 44.5 µM -0.8345025438937 0.220669799179982 no 2607 0.201998927223296 3787 1270615
SGTC_476 mead acid 10 µM -0.835912554926929 0.220266423414932 no 2608 0.201602049423283 3892 5312531 An omega 9 fatty acid.
SGTC_2273 7815444 169.05 µM -0.836186337547017 0.220188148764548 no 2609 0.201525041635117 3801 2824616
SGTC_570 0987-0065 62.6 µM -0.836731219879035 0.220032413984437 no 2610 0.201371833143262 3689 3104428
SGTC_2369 9071472 200 µM -0.837068864555893 0.219935942264144 no 2611 0.201276930200362 3966 17296037
SGTC_2606 farnesol 9.78 µM -0.839206159865359 0.219325838355737 no 2612 0.200676815622523 3926 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1953 st076800 12.1 µM -0.839692745579538 0.219187075557228 no 2613 0.200540341250873 3927 297591
SGTC_2407 paclitaxel 400 µM -0.840132101054525 0.219061825082755 no 2614 0.200417161602161 4064 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2419 paclitaxel 166.5 µM -0.840374085411311 0.218992858305095 no 2615 0.200349337208522 3823 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2962 9082311 13.18 µM -0.840438410851114 0.218974527327462 no 2616 0.200331310123847 3893 16459453
SGTC_377 3970-0964 33.1 µM -0.841792377955513 0.21858888886308 no 2617 0.199952089540779 3871 16481235
SGTC_3150 9097574 49.47 µM -0.841855407658847 0.218570946200277 no 2618 0.199934446633825 3891 17217476
SGTC_1856 st057054 55.7 µM -0.844353514714964 0.217860493277188 no 2619 0.199235945101895 3898 1266018
SGTC_2532 xanthone 78.9 µM -0.845031742336179 0.217667837839101 no 2620 0.199046558280208 3884 7020 An insecticide.
SGTC_2457 5731572 11.68 µM -0.846424214837805 0.217272604245161 no 2621 0.198658067374412 3972 2865357
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.846546556519002 0.217237899110859 no 2622 0.198623956695213 3939 688798
SGTC_650 1328-0195 38 µM -0.847110043108543 0.217078094048764 no 2623 0.198466893865734 3825 2780821
SGTC_134 0269-0018 6.916 µM -0.847875734842649 0.216861052412193 no 2624 0.198253589730052 3864 4378915
SGTC_2801 7907800 81.82 µM -0.847933702876478 0.216844626004965 no 2625 0.198237446803354 3950 6620925
SGTC_1113 artemisinin 1.17947 µM -0.847978886514742 0.216831822812005 no 2626 0.198224864622892 3923 2240 An anti-malaria and mitochondrial poison.
SGTC_2528 xanthyletin 44.79 µM -0.852393411915658 0.215583035928356 no 2627 0.196997887735489 3948 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1282 0886-0010 32.4 µM -0.853288593879362 0.215330315219484 no 2628 0.19674964188727 3974 2836211 YNL267W PIK1
SGTC_919 tnp00227 403.569 nM -0.854492599007518 0.214990681223604 no 2629 0.196416054200309 3903 1269246 A methoxyflavone. YNL221C POP1
SGTC_2453 5731132 22.18 µM -0.854904287006931 0.214874620868518 no 2630 0.196302068554087 3949 1362040
SGTC_334 1502-1024 68.5 µM -0.85570662984866 0.214648534298593 no 2631 0.196080036058881 3963 3296216
SGTC_3038 9091290 49.47 µM -0.856240644591076 0.214498134687016 no 2632 0.195932342515242 3893 25236843
SGTC_2119 5528445 120.635 µM -0.85647256157791 0.214432836804175 no 2633 0.195868221789727 3927 791935
SGTC_2134 5324836 1.464 µM -0.859268060271312 0.213646654061417 no 2634 0.195096320685332 3880 699272
SGTC_3244 9134489 49.47 µM -0.860338255686642 0.213346126272564 no 2635 0.194801305373046 3942 16584271
SGTC_506 n9-isopropylolomoucine 153 µM -0.861294475628289 0.213077813198333 no 2636 0.194537938767151 3896 6610355
SGTC_2945 9067681 61.76 µM -0.861596122727646 0.212993212590643 no 2637 0.194454902683758 4007 16456930
SGTC_626 0214-0009 33 µM -0.864549605739904 0.212165908241678 no 2638 0.193643021158563 3984 3437874
SGTC_1007 4101-0031 70 µM -0.86520346199087 0.211983009944593 no 2639 0.193463562784719 3884 1146276
SGTC_1763 st044482 94.5 µM -0.865449607180126 0.211914181498758 no 2640 0.193396031698902 3957 88505
SGTC_399 oxolinic acid 75 µM -0.866148560756753 0.211718807608718 no 2641 0.193204348929888 3889 4628 A DNA gyrase inhibitor.
SGTC_3339 9145883 14.936 µM -0.870591993818332 0.21047923156024 no 2642 0.191988484747767 3856 2030670
SGTC_2023 5144124 124 µM -0.871182668103254 0.21031477365097 no 2643 0.191827210900977 3925 2830192
SGTC_1753 st043925 64 µM -0.871240971461892 0.210298544687773 no 2644 0.191811296631621 3980 670181
SGTC_2477 5967686 25.23 µM -0.871626953107298 0.210191123768117 no 2645 0.191705960898488 3923 776118
SGTC_2050 5263056 171 µM -0.874019002547255 0.209526121703667 no 2646 0.191053952646394 3961 763468 YGL055W OLE1
SGTC_1571 st070080 73.4 µM -0.876139387613035 0.208937679838242 no 2647 0.190477131290505 4001 4315245
SGTC_2575 plumbagin 510 nM -0.878503764137869 0.208282675641685 no 2648 0.18983519794204 3851 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2492 derrusnin 100 µM -0.880114658006288 0.207837103726905 no 2649 0.189398599620543 3841 1715307 Part of coumarin class of compounds.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.880868329624298 0.207628832223659 no 2650 0.189194545433895 3967 2374 Ca(2+)-ATPase inhibitor.
SGTC_3270 9137563 49.47 µM -0.880988130216586 0.207595737590344 no 2651 0.189162122279053 3931 17015724
SGTC_1034 k072-0165 12.7 µM -0.881320200239175 0.207504020319526 no 2652 0.189072267842224 3991 5835461
SGTC_1386 3228-0095 33.8 µM -0.88135475539643 0.207494477609879 no 2653 0.189062919113205 3968 870181
SGTC_2948 9070189 9.45 µM -0.882288712775346 0.207236655349723 no 2654 0.188810349355754 3884 6473636 YDL196W YDL196W
SGTC_2925 9010536 32.5 µM -0.884590922524383 0.206601931808635 no 2655 0.188188652151864 3910 2994177
SGTC_2099 5377090 177.372 µM -0.886422639833725 0.206097747359539 no 2656 0.187694911919701 3984 2243829
SGTC_1420 4'-methoxyflavone 42 µM -0.887429516724293 0.205820913169328 no 2657 0.187423848949784 3922 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3012 9080433 71.4286 µM -0.888675034454934 0.205478771685671 no 2658 0.187088876060377 3924 17688859
SGTC_970 1315-0089 19.5 µM -0.888856440162609 0.205428968054929 no 2659 0.187040119234757 3899 6811083 YLR033W RSC58
SGTC_2564 betulinic acid 100 µM -0.889520814212239 0.205246630157561 no 2660 0.186861621024569 4016 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3322 9139058 2.11 µM -0.892460036962352 0.204441112926088 no 2661 0.186073201864054 4054 4908926 YPR165W RHO1
SGTC_1663 st014140 55.4 µM -0.892583153010384 0.204407413110662 no 2662 0.186040222189193 4034 4207120
SGTC_814 3342-0569 96 µM -0.893488512692394 0.20415969603187 no 2663 0.185797810551354 3992 4346283
SGTC_3153 9100258 49.47 µM -0.895231998369532 0.203683161797938 no 2664 0.1853315414402 3887 25236848
SGTC_1429 4049-0205 9.46 µM -0.895267598572396 0.203673438368156 no 2665 0.185322028274501 3982 22774478
SGTC_591 4299-0174 154 µM -0.895274616596905 0.203671521578352 no 2666 0.185320152938098 3938 5509088
SGTC_2874 9043904 71.43 µM -0.896169425909712 0.203427215946172 no 2667 0.185081141089177 3924 4463428
SGTC_1655 st012546 55.1 µM -0.896813015433632 0.203251607829253 no 2668 0.184909350823577 3951 720985 YLR208W SEC13
SGTC_1384 3089-0840 101 µM -0.897875516073389 0.202961894800635 no 2669 0.184625959532989 3945 1069836
SGTC_1442 4112-3290 3 µM -0.898043554385449 0.202916098236555 no 2670 0.184581164923669 3935 704353
SGTC_2003 4023581 200 µM -0.899480508776227 0.202524727916652 no 2671 0.184198386611602 4016 16641307
SGTC_2223 6903751 107.57 µM -0.8999990213991 0.202383616174914 no 2672 0.184060385738139 3927 5598863
SGTC_2429 5902844 64.44 µM -0.900365346861258 0.202283957190853 no 2673 0.183962927918769 4004 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1165 k072-0275 30.3 µM -0.90206093070228 0.201823055458526 no 2674 0.183512250740138 3948 6153523 YGL055W OLE1
SGTC_3125 9127534 49.47 µM -0.9027031414243 0.201648650973784 no 2675 0.183341734375674 3846 1639235
SGTC_2179 6298986 200 µM -0.902774538610132 0.201629267293419 no 2676 0.183322783479639 3935 738374
SGTC_1745 st081495 74 µM -0.903525954159516 0.20142533256819 no 2677 0.183123409948638 3888 13842402 YBL026W LSM2
SGTC_3239 9133757 49.47 µM -0.90416855265052 0.201251028971076 no 2678 0.182953016250097 3978 17036923
SGTC_1148 3909-7663 27.7 µM -0.904856190806406 0.201064608648647 no 2679 0.182770789295905 4017 4084526
SGTC_2317 5986382 200 µM -0.905078168721434 0.201004452034694 no 2680 0.182711988431047 4000 877883
SGTC_51 1013-0126 23.419 µM -0.905373075174584 0.200924548292531 no 2681 0.182633887424014 3959 1627850
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.905616970383257 0.200858480246473 no 2682 0.182569311638156 3957 641818 YHR062C RPP1
SGTC_1815 st051655 58.2 µM -0.906011720861175 0.20075157509539 no 2683 0.182464824340019 3928 5984156
SGTC_2769 toremifene 3.73 µM -0.9086631721152 0.200034402449767 no 2684 0.18176397481511 3980 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.910501121745568 0.199538173334252 no 2685 0.181279145210048 3979 75037 A free radical scavenger.
SGTC_1366 1683-0113 21.9 µM -0.913168949371118 0.198819204610762 no 2686 0.180576845923274 3988 708623
SGTC_2152 5568786 200 µM -0.915506185399712 0.19819061416918 no 2687 0.179962978389553 3958 5399883
SGTC_1281 0884-0031 11.8 µM -0.920752061767294 0.19678413152024 no 2688 0.178589944159775 4014 1548255
SGTC_201 4262-0159 12.803 µM -0.921167535255507 0.196672996988335 no 2689 0.178481482494428 4022 1341029
SGTC_2696 st077691 74.316 µM -0.922266511478219 0.196379216418544 no 2690 0.178194788724484 4048 757133
SGTC_2418 pentamidine 31.67 µM -0.925154559318116 0.195608446518008 no 2691 0.177442758207572 3974 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3090 9117696 49.47 µM -0.927465154320182 0.194993113352098 no 2692 0.176842537876178 3962 7923821
SGTC_363 0455-0021 3.06 µM -0.928584193879132 0.194695526076923 no 2693 0.17655230819272 4001 4597466
SGTC_365 0121-0052 13.6 µM -0.929698079841254 0.194399583866927 no 2694 0.176263714474146 4052 3101739
SGTC_69 0096-0274 206.684 µM -0.930575627174151 0.194166626134745 no 2695 0.176036563456138 4164 6741392
SGTC_3228 9131799 49.47 µM -0.932025918174228 0.193781998162097 no 2696 0.175661565567535 4006 17015818
SGTC_1202 1988-0068 29.6 µM -0.933703646967771 0.193337631899933 no 2697 0.175228391630528 3967 2850480
SGTC_1922 5578187 25 µM -0.93508565278405 0.192972058816587 no 2698 0.174872079902315 4042 1350412
SGTC_2442 5158906 48.48 µM -0.935326846161353 0.192908300781744 no 2699 0.174809942064427 4044 1893835
SGTC_2561 acetosyringone 100 µM -0.937910302253338 0.192226186795438 no 2700 0.174145254163939 4019 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3165 9101544 49.47 µM -0.938815201247161 0.1919876142039 no 2701 0.173912816409994 4026 5002184
SGTC_1345 1488-0192 31.4 µM -0.940933661602364 0.191429800694649 no 2702 0.173369428021869 4054 658348
SGTC_946 3434-1334 87.4 µM -0.941788615584161 0.191204963626558 no 2703 0.173150437442627 4019 4047976
SGTC_845 0330-0138 4.51 µM -0.943352759846004 0.190794041892331 no 2704 0.172750248872782 3985 9039800
SGTC_3224 9130643 49.47 µM -0.946655831886966 0.189928062628976 no 2705 0.171907091945122 4074 17644395
SGTC_1265 0819-1001 68.8 µM -0.946925223583713 0.189857541890928 no 2706 0.171838441902231 3987 3106768
SGTC_785 1270-0111 65.3 µM -0.946936881879275 0.189854490372652 no 2707 0.171835471372642 3963 6741994
SGTC_699 0375-0592 111 µM -0.948139150957464 0.189539962555797 no 2708 0.171529309712634 4107 762578
SGTC_1656 st012921 11 µM -0.949193444752906 0.189264410833777 no 2709 0.171261117476232 3951 6732821
SGTC_2545 solidagenone 89.61 µM -0.950619688028924 0.188892038587136 no 2710 0.170898735295499 3834 6708572 An anti ulcer agent
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.951575681245081 0.188642694952879 no 2711 0.170656109850095 4040 7104
SGTC_1133 3473-0247 50 µM -0.951913411622417 0.188554656117422 no 2712 0.170570448605422 4031 711311
SGTC_1939 st074455 53.6 µM -0.955266981680722 0.187681829950178 no 2713 0.169721350240658 4068 1644229
SGTC_1251 0490-5699 265 µM -0.955767226575076 0.187551846590615 no 2714 0.169594924795894 4101 3883818
SGTC_2416 tofa 880 nM -0.955778988284686 0.187548791103913 no 2715 0.169591953020181 4067 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2227 7312221 64.1025 µM -0.957037863232677 0.187221935234823 no 2716 0.169274072170705 4096 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1546 5-methoxyflavanone 78.7 µM -0.958569316201902 0.186824782100589 no 2717 0.168887878177099 4019 147795
SGTC_3221 9128209 49.47 µM -0.959554357429406 0.186569606190593 no 2718 0.168639774886014 4079 16460723
SGTC_1736 st036774 51 µM -0.960887596730323 0.18622457315533 no 2719 0.168304343935936 4117 1272247
SGTC_3347 9188721 44.724 µM -0.962584334396653 0.185786041522301 no 2720 0.167878081121805 4075 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_3188 9110789 49.47 µM -0.963121294619629 0.185647394595565 no 2721 0.167743328224107 4035 849217
SGTC_2048 5246248 200 µM -0.964897032478699 0.18518934389043 no 2722 0.167298193968531 4062 677046
SGTC_1046 2001-0062 216 µM -0.965278040544079 0.185091154582232 no 2723 0.16720278381216 3960 739778
SGTC_1333 1482-0047 286 µM -0.965559732996848 0.185018580625362 no 2724 0.167132266338257 4052 3811116
SGTC_2448 5185112 27.17 µM -0.965794220109431 0.18495818192243 no 2725 0.16707358063832 4076 5718189
SGTC_1261 0712-0010 12.7 µM -0.966903954928667 0.184672504958975 no 2726 0.166796024684541 4076 2840123
SGTC_985 1493-0307 8.71 µM -0.967413815127198 0.184541344627054 no 2727 0.166668603262198 4061 3278274
SGTC_2666 tannic acid 100 µM -0.967686005838236 0.184471347935523 no 2728 0.166600604601042 4059 16134267 A thiamine antagonist.
SGTC_2543 pimpinellin 60.67 µM -0.968206665379421 0.184337500897706 no 2729 0.166470583368014 3884 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1086 cerivastatin 2.18 µM -0.968927935109162 0.184152182439897 no 2730 0.166290573201437 4030 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_185 k048-0037 25.491 µM -0.9702733325119 0.18380681461333 no 2731 0.165955133073974 4099 6827589
SGTC_1229 0139-0193 12.2 µM -0.972581908625658 0.183215136563573 no 2732 0.165380568865134 4123 3090752
SGTC_429 1112-0049 25.5 µM -0.973011166918485 0.18310525063835 no 2733 0.165273876059133 4020 2836170
SGTC_1597 7-benzyloxygramine 47.5 µM -0.974755939880489 0.18265902913037 no 2734 0.164840668661844 4001 260807
SGTC_98 0074-0023 107.663 µM -0.975819890711237 0.182387259812031 no 2735 0.164576863010533 4083 3563821
SGTC_2988 9073640 71.4286 µM -0.978065648401598 0.181814446645077 no 2736 0.164020928158806 4132 9102229
SGTC_968 1309-0633 340 µM -0.980874198837942 0.181099670595665 no 2737 0.163327391181565 4120 3761976
SGTC_1881 5652484 16 µM -0.981183169016154 0.181021145315183 no 2738 0.163251211286095 4043 2255129
SGTC_2875 9039966 71.43 µM -0.981203398339877 0.181016004743428 no 2739 0.163246224335808 4083 6463691
SGTC_1635 st007035 42.4 µM -0.981500794343921 0.18094044255663 no 2740 0.163172921441361 4038 3716403
SGTC_1048 3161-0300 24.5 µM -0.981573814487784 0.180921892668062 no 2741 0.163154926528966 4058 2165101
SGTC_3193 9111931 49.47 µM -0.985632644819837 0.179892670492924 no 2742 0.162156706318929 4092 17087244
SGTC_2404 5161160 200 µM -0.987348003672966 0.179458804222039 no 2743 0.161736032622579 4034 2831543
SGTC_2258 7960471 200 µM -0.989875092354506 0.178820826359609 no 2744 0.161117587621557 4113 2974708
SGTC_236 1509-0011 5.31 µM -0.99049379028694 0.178664850373565 no 2745 0.160966411426189 4125 3107280
SGTC_2956 9076196 2.52 µM -0.991951239926817 0.178297760766293 no 2746 0.160610655892 4107 16423868
SGTC_1139 k015-0024 46.9 µM -0.992305248734671 0.178208667932074 no 2747 0.160524321845477 4110 2766652
SGTC_2490 carminic acid 95.39 µM -0.9935541419584 0.177894585111009 no 2748 0.160219989668284 4047 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3227 9130768 49.47 µM -0.995505316380006 0.177404585613744 no 2749 0.159745279943402 4131 17720899
SGTC_315 k915-0449 187 µM -0.996346265357016 0.177193660655109 no 2750 0.159540965874212 4096 20970215 YNL149C PGA2
SGTC_2740 felodipine 17.08 µM -0.99697034066123 0.177037233902339 no 2751 0.159389453299769 4091 3333 L-type calcium channel blocker
SGTC_3353 9151644 39.2805 µM -0.997999562535372 0.176779446346204 no 2752 0.159139785386985 4127 4909158
SGTC_421 streptovitacin 30 mM -0.998662011802583 0.1766136493192 no 2753 0.158979224494417 4162 91467 include heat shock
SGTC_1520 flindersine 88 µM -0.999971148713425 0.17628628934636 no 2754 0.158662235198881 4192 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_827 3253-0474 693 µM -1.00133473662707 0.175945722002593 no 2755 0.158332502280768 4137 5402065
SGTC_1547 harmine 94.2 µM -1.00270857796719 0.17560301542697 no 2756 0.158000744953595 4057 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1608 st001473 40.5 µM -1.00680672753673 0.174583241476112 no 2757 0.157013830532685 4067 7292267
SGTC_1476 4112-3294 3.34 µM -1.01053459966235 0.173658879740746 no 2758 0.156119615658953 4120 704369
SGTC_2182 6325192 200 µM -1.01061415377785 0.173639187527852 no 2759 0.156100569438708 4040 736248
SGTC_484 loperamide 105 µM -1.01094702453546 0.173556806675205 no 2760 0.156020892749081 4091 3955 An opioid-receptor agonist.
SGTC_3200 9114385 49.47 µM -1.01250346784843 0.173171938857968 no 2761 0.155648694718853 4151 17018030 YLR208W SEC13
SGTC_3034 9090421 49.47 µM -1.01311071290531 0.173021930513052 no 2762 0.155503640906435 3982 17173761
SGTC_2427 5545055 42.75 µM -1.0136941968729 0.172877869904632 no 2763 0.155364346994592 4072 5372858
SGTC_2264 7948757 110.76 µM -1.01475214209398 0.172616861101389 no 2764 0.15511199599232 4059 2971411
SGTC_178 4092-0806 87.505 µM -1.01543098979154 0.172449512979353 no 2765 0.154950213495304 3993 2169044
SGTC_2474 5321570 43.32 µM -1.01661804263317 0.172157131951048 no 2766 0.154667583820675 4113 2841384
SGTC_794 k038-0031 316 µM -1.01666281217405 0.172146111033625 no 2767 0.154656931150252 4093 6624242
SGTC_213 1246-0773 967 nM -1.01706633783209 0.172046795446702 no 2768 0.154560936279589 4107 6251622
SGTC_2014 4013930 200 µM -1.01723169021267 0.172006109545969 no 2769 0.154521611916802 4042 64556
SGTC_1955 wogonin 32.4 µM -1.01881121957553 0.171617766915328 no 2770 0.154146299106409 4180 5281703 A flavanone.
SGTC_2157 5649910 96.377 µM -1.02068100603654 0.171158786386304 no 2771 0.15370279816844 4119 2858091
SGTC_1658 st012944 20 µM -1.0206999205458 0.171154147414987 no 2772 0.15369831609272 3977 24207260
SGTC_1506 4226-2149 212 µM -1.0209903447214 0.171082928096276 no 2773 0.153629506607412 4126 991114
SGTC_3005 9076496 71.4286 µM -1.02100448431257 0.171079461196526 no 2774 0.153626157069653 4078 21368410
SGTC_2390 9097792 176.6 µM -1.02223099831679 0.170778902076712 no 2775 0.153335791316373 4108 4497149
SGTC_2954 9074818 52.69 µM -1.02241905453305 0.170732848512567 no 2776 0.153291302929863 4145 16648742
SGTC_2313 7726885 200 µM -1.02346839529888 0.170476018730741 no 2777 0.153043217803019 4155 726423
SGTC_1362 1611-0397 101 µM -1.02400716551999 0.170344249030904 no 2778 0.152915945218656 4083 27816
SGTC_3172 9105863 49.47 µM -1.02480450640645 0.170149359179712 no 2779 0.152727719832168 4156 2348785
SGTC_1475 4092-1048 11.7 µM -1.02541255533723 0.170000833035153 no 2780 0.15258428323951 4125 2881759
SGTC_1790 st045711 43.5 µM -1.02747441894447 0.169497807211881 no 2781 0.152098562486407 4113 585119
SGTC_3301 9125354 19.7965 µM -1.0278993754345 0.169394250854146 no 2782 0.151998581695643 4087 41905162
SGTC_1279 0874-0590 65.2 µM -1.02807886408708 0.169350524008694 no 2783 0.151956365976604 4172 3523074
SGTC_2820 7989630 71.43 µM -1.02814210740476 0.169335118461353 no 2784 0.15194149300835 4123 2984098
SGTC_2976 9009005 19.48 µM -1.03177165487841 0.168452498183137 no 2785 0.151089550395927 4173 2993148
SGTC_2151 5563267 85.4165 µM -1.03188205553337 0.168425697789753 no 2786 0.151063686598615 4169 5310824
SGTC_1814 st052110 31.539 µM -1.03385631429336 0.167946898109564 no 2787 0.150601670194791 4078 674163
SGTC_1616 st002734 56.1 µM -1.03641044209726 0.167328769112243 no 2788 0.150005350450497 4076 4026101
SGTC_2116 5511452 16.8835 µM -1.03676950581283 0.167241989162494 no 2789 0.149921645180905 4160 870744
SGTC_2318 6029776 164 µM -1.04143427080626 0.166117227484607 no 2790 0.148837021999496 4182 818325
SGTC_1383 3049-0032 20.7 µM -1.0415909675737 0.166079530009357 no 2791 0.148800679068334 4190 712864
SGTC_1819 st053448 58.6 µM -1.0422432921231 0.165922655808991 no 2792 0.148649448134934 4042 2857616
SGTC_1915 st067105 30.6 µM -1.04240462907117 0.165883871486862 no 2793 0.148612060618231 4079 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1380 2291-0730 164 µM -1.04429842120747 0.165429054660006 no 2794 0.148173671551312 4163 2999191
SGTC_3328 9140624 29.0385 µM -1.04431476709812 0.165425132513825 no 2795 0.148169891453578 4154 4904392
SGTC_567 1080-0542 68.4 µM -1.04799688726875 0.164543152324776 no 2796 0.147320020506189 4001 5950415
SGTC_1800 st050079 29.0735 µM -1.04884881174758 0.16433952531973 no 2797 0.147123853941703 4004 3645560
SGTC_3156 9099931 49.47 µM -1.04955325117503 0.164171273649453 no 2798 0.146961780039958 4176 18111053
SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.04970466829009 0.164135123056901 no 2799 0.146926958388201 4191 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3185 9108267 49.47 µM -1.05023146496593 0.164009391431387 no 2800 0.146805853179976 4150 4910486
SGTC_1882 5615643 20 µM -1.05082198403099 0.163868525355134 no 2801 0.146670178468919 4096 2253075
SGTC_2379 9035213 200 µM -1.05148908592219 0.163709485215905 no 2802 0.146517009714436 4143 646551
SGTC_1061 3448-9325 110 µM -1.05220721424704 0.163538392170161 no 2803 0.146352245164923 4071 723482
SGTC_20 0481-0013 4.944 µM -1.05267193355034 0.163427735367406 no 2804 0.146245688115834 4171 182045
SGTC_2689 tacrolimus 100 µM -1.05760098326327 0.162257047287248 no 2805 0.145118697033758 4169 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2894 9048625 32.47 µM -1.0576143546416 0.162253878923422 no 2806 0.145115647737122 4152 4092861
SGTC_2929 9013348 24.6 µM -1.05790156586054 0.162185833611578 no 2807 0.145050160621479 4141 2995952
SGTC_3309 9129340 25.759 µM -1.06079127403048 0.161502245817455 no 2808 0.144392384332383 4178 17158987
SGTC_917 harmaline 728.087 nM -1.06257883023684 0.161080324336495 no 2809 0.143986495777341 4120 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_815 1582-0027 36.9 µM -1.06347644674325 0.160868729131693 no 2810 0.143782970437922 4189 3128206
SGTC_2872 9044037 25.97 µM -1.06503173830493 0.160502529921146 no 2811 0.143430783749461 4162 6465195
SGTC_2437 5741531 144.16 µM -1.06593797938313 0.160289403384729 no 2812 0.143225839530274 4183 2262990
SGTC_1084 voriconazole 435 nM -1.06614798013305 0.16024004256806 no 2813 0.143178376611373 4158 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1192 1488-0095 21.4 µM -1.06694951656815 0.160051732236792 no 2814 0.142997316554197 4210 915875
SGTC_2645 abamectin 100 µM -1.06744991173925 0.159934244439504 no 2815 0.142884360145362 4114 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1796 st049173 110.4 µM -1.06793141242446 0.159821246144028 no 2816 0.142775725817994 4119 94134
SGTC_3000 9075062 71.4286 µM -1.06836186465911 0.15972027209473 no 2817 0.142678656124349 4113 17057871
SGTC_1199 1638-0010 4.46 µM -1.06947632506302 0.15945903966854 no 2818 0.142427545624031 4145 3111136
SGTC_111 0083-0039 52.457 µM -1.06949803754299 0.159453952985911 no 2819 0.14242265633324 4032 759313
SGTC_2012 4023501 200 µM -1.06952240196571 0.159448245146928 no 2820 0.142417170004058 4186 3477460
SGTC_2231 micatex 6.853 µM -1.07382085042781 0.158443343625198 no 2821 0.141451491509248 4177 20737 An antifungal of unknown mechanism.
SGTC_1220 1838-0075 193 µM -1.07445075571773 0.158296432623776 no 2822 0.141310352246465 4073 5529645
SGTC_865 0488-0499 301 µM -1.07458072721319 0.158266130872309 no 2823 0.141281242164069 4132 9634651
SGTC_92 0063-0024 660.874 µM -1.07475059522576 0.158226533324757 no 2824 0.14124320247499 4255 3594437
SGTC_1408 3909-7976 48.8 µM -1.07735867481889 0.157619386067817 no 2825 0.140660029311199 4210 24152374
SGTC_2833 9001315 45.46 µM -1.07829229273394 0.157402417244912 no 2826 0.140451667747857 4136 2989378
SGTC_1347 1493-0251 600 nM -1.07912281747304 0.157209571905583 no 2827 0.140266490364696 4224 3986378
SGTC_2735 sertaconazole 140 nM -1.08101412713308 0.156770995466833 no 2828 0.139845414781927 4306 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3081 9117243 49.47 µM -1.08165872341673 0.156621703972781 no 2829 0.13970210029262 4159 45595589
SGTC_1312 1218-2183 165 µM -1.0816841958753 0.156615806355912 no 2830 0.139696438997387 4222 6744073
SGTC_1842 st055362 61.2 µM -1.08595585881207 0.155628859712284 no 2831 0.138749260890159 4149 676032
SGTC_1788 fluconazole 20 µM -1.08698656040467 0.155391336847123 no 2832 0.138521374631869 4219 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_846 0335-0850 148 µM -1.0905523724569 0.154571449714187 no 2833 0.137734948198771 4154 6819598
SGTC_336 4111-0029 111 µM -1.09201192205751 0.154236681642185 no 2834 0.137413930487902 4180 3131175
SGTC_342 k048-0088 23.3 µM -1.09285764187692 0.154042923579176 no 2835 0.137228154288886 4170 6820570
SGTC_683 panaxydol 45 µM -1.09517731845223 0.153512302606377 no 2836 0.136719480240367 4170 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1088 bifonazole 369 nM -1.10246623797194 0.151852864585587 no 2837 0.135129514296905 4151 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1696 st025591 34.7925 µM -1.10303000258297 0.151725013071793 no 2838 0.135007068119008 4202 2787147
SGTC_2280 7785178 200 µM -1.10524715956317 0.151222896439759 no 2839 0.134526253627504 4187 2954328
SGTC_2963 9082507 9 µM -1.10555947940337 0.151152254699311 no 2840 0.134458618261642 4236 16459611
SGTC_1235 benzylparaben 21.5 µM -1.10662948167326 0.150910403817141 no 2841 0.134227077710207 4223 7180
SGTC_329 k048-0121 21.3 µM -1.10722515672694 0.15077587601938 no 2842 0.134098296781771 4209 6832902
SGTC_2910 7948405 25.97 µM -1.10908319680325 0.150356767635612 no 2843 0.133697146490379 4115 2971328
SGTC_2338 7999974 200 µM -1.10983558234246 0.15018727698318 no 2844 0.133534941601648 4208 315925
SGTC_2851 9015922 71.43 µM -1.11229266774312 0.149634654191316 no 2845 0.13300616771194 4227 2996893
SGTC_101 0490-5701 117.494 µM -1.1126766959306 0.149548405212791 no 2846 0.132923653846977 3988 4661669
SGTC_145 3737-0113 38.366 µM -1.11280302093596 0.149520041103999 no 2847 0.132896518845437 4158 6849351
SGTC_3184 9108758 49.47 µM -1.11302192910904 0.149470897538286 no 2848 0.132849505725063 4233 902885
SGTC_1322 1348-1070 12 µM -1.11329719505273 0.149409117295817 no 2849 0.132790405362417 4196 6758089
SGTC_1320 1313-0481 95.3 µM -1.1166198829078 0.148664723397418 no 2850 0.132078443293441 4188 6813365 YLR208W SEC13
SGTC_551 k048-0028 34.9 µM -1.11748529244894 0.148471250193656 no 2851 0.13189344232025 4196 6836383
SGTC_483 fpl-64176 144 µM -1.12010586000858 0.147886416607074 no 2852 0.13133432687814 4309 3423
SGTC_2054 5233173 129 µM -1.12096565251589 0.147694872680367 no 2853 0.131151241539831 4254 6889
SGTC_1256 0570-0116 285 µM -1.1220392549905 0.147455929693484 no 2854 0.130922874839109 4208 410638
SGTC_2206 7254556 146.969 µM -1.12335338120229 0.147163808026123 no 2855 0.130643720387059 4225 4398905
SGTC_328 k915-0120 63.5 µM -1.12359328702697 0.147110520437011 no 2856 0.130592802628676 4198 6624543
SGTC_52 0329-0193 875 nM -1.12720837043616 0.146309108781315 no 2857 0.129827196146664 4299 3739292
SGTC_540 1187-0821 17.3 µM -1.12721865747798 0.146306832484016 no 2858 0.129825021988928 4157 847520
SGTC_2356 9061756 188.97 µM -1.12731016140737 0.146286585712913 no 2859 0.129805683819026 4250 20104043
SGTC_523 1934-0222 13.7 µM -1.12824154136736 0.146080609399171 no 2860 0.129608962204433 4165 1361595
SGTC_1035 k081-0041 55.2 µM -1.12971220849169 0.145755765664544 no 2861 0.129298755612106 4247 731709
SGTC_2434 5670830 169.91 µM -1.13054382149358 0.145572292491532 no 2862 0.129123572111349 4255 1549830
SGTC_835 0312-0010 67.2 µM -1.13237520096441 0.145168795357125 no 2863 0.128738363142128 4218 1626196
SGTC_1652 st011932 78 µM -1.13271610808241 0.145093768453791 no 2864 0.128666745481718 4167 1551076
SGTC_3037 9091026 49.47 µM -1.13331745432517 0.144961487687997 no 2865 0.128540482253888 4148 25236398 YIL048W NEO1
SGTC_3138 9097216 49.47 µM -1.13332576473823 0.144959660178984 no 2866 0.128538737939033 4173 25237486
SGTC_2236 dapsone 200 µM -1.13483108629772 0.144628886899267 no 2867 0.128223049311671 4213 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1428 4049-0204 61.7 µM -1.13618283603229 0.14433229247252 no 2868 0.127940026191423 4277 X1428
SGTC_1020 4335-0961 93.3 µM -1.1381378025753 0.143904068768203 no 2869 0.127531472608232 4184 669075
SGTC_67 0335-0847 266 µM -1.14178415650295 0.143107648847099 no 2870 0.126771874765693 4334 4552207 YOR254C SEC63
SGTC_1058 3448-5425 97.3 µM -1.14181554673271 0.143100805689404 no 2871 0.126765349349689 4172 7279705
SGTC_1273 0849-0096 14.1 µM -1.14360855121556 0.142710292634989 no 2872 0.126393006872587 4260 5286025
SGTC_804 1595-0054 20.9 µM -1.14471697574682 0.142469240523846 no 2873 0.126163208516244 4174 761523 Stimulates phospholipase C.
SGTC_173 1273-0061 2.693 µM -1.14607480064251 0.142174326149281 no 2874 0.125882101629347 4213 2847414 YPL266W DIM1
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.14681496825529 0.142013738683041 no 2875 0.125729050782006 4194 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_186 3455-3465 67.277 µM -1.14773897200746 0.141813438339178 no 2876 0.125538168791305 4237 755278
SGTC_469 w7 172 µM -1.14886588031236 0.141569412551615 no 2877 0.125305644336534 4321 45115570 A P450 inhibitor.
SGTC_279 1273-0055 2.93 µM -1.15338588171104 0.14059349131874 no 2878 0.124376016873199 4254 2847562
SGTC_3001 9076041 71.4286 µM -1.15697294730153 0.139822259149838 no 2879 0.123641706589427 4221 16004211
SGTC_1625 st003711 30.1 µM -1.1583105695011 0.139535403012136 no 2880 0.123368659816335 4313 24207034 YER133W GLC7
SGTC_50 0929-0078 56.389 µM -1.16063139727687 0.139038646437143 no 2881 0.122895915698819 4100 1377751
SGTC_939 1165-0479 45.3 µM -1.16137524551244 0.138879686120064 no 2882 0.122744665691054 4246 1377347
SGTC_3131 9127911 49.47 µM -1.16547373335296 0.138006059336861 no 2883 0.121913643242644 4304 45595681
SGTC_2211 7117706 200 µM -1.16670156010821 0.137745069079091 no 2884 0.121665456288522 4175 822771
SGTC_1723 st034307 2.5525 µM -1.16835695797634 0.13739372658368 no 2885 0.121331404550405 4277 867466
SGTC_193 1273-0060 1.558 µM -1.17162791449884 0.136701297503358 no 2886 0.12067323786768 4093 2847393 YHR072W ERG7
SGTC_223 busulfan 5 mM -1.17206913158509 0.136608079162962 no 2887 0.120584650966652 4262 2478 A DNA alkylator.
SGTC_2736 butenafine 14.65 µM -1.17377532121427 0.136248012285604 no 2888 0.120242515721033 4195 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2864 9034755 47.6 µM -1.17412432456726 0.136174440206928 no 2889 0.120172615842957 4191 4930451
SGTC_1236 0330-0013 258 µM -1.17490633626153 0.136009686004127 no 2890 0.120016095178814 4274 4617066
SGTC_753 1322-0200 289 µM -1.17514027787885 0.135960425718668 no 2891 0.119969299392297 4328 5403907
SGTC_3061 glucosamine 200 µM -1.17579820456487 0.135821953836691 no 2892 0.119837762020049 4190 91431 and experimental redox chemotherapeutic
SGTC_1646 st011709 75.6 µM -1.17812276022021 0.135333485086955 no 2893 0.119373834771159 4223 5757843
SGTC_2022 5136654 200 µM -1.17850319006893 0.1352536585489 no 2894 0.119298030659879 4291 1713771
SGTC_2149 5554786 194.827 µM -1.18050235251537 0.134834699893086 no 2895 0.118900237674291 4302 745063 YPR165W RHO1
SGTC_990 3985-0011 41.3 µM -1.18139984331373 0.134646905237308 no 2896 0.118721960125282 4242 5399565 YGL099W LSG1
SGTC_326 k292-0812 17.5 µM -1.18251343431798 0.134414142539759 no 2897 0.118501019069339 4257 3579357
SGTC_2383 9036125 200 µM -1.1837876579885 0.134148143520134 no 2898 0.118248564509194 4188 79580
SGTC_154 3389-1638 511.116 µM -1.18405214450475 0.134092976307141 no 2899 0.118196211020679 4267 5238686
SGTC_2388 9080168 200 µM -1.18423346192796 0.134055165703403 no 2900 0.118160329816682 4277 15943073
SGTC_3296 9122258 64.045 µM -1.18425717612488 0.134050221060674 no 2901 0.118155637544805 4247 4730474
SGTC_2181 6316240 54.2555 µM -1.18610259045732 0.13366581832507 no 2902 0.117790893832813 4285 12779990
SGTC_1211 1056-0033 32.3 µM -1.18681933254086 0.133516724354195 no 2903 0.117649445752141 4330 6741922
SGTC_165 k038-0023 64.381 µM -1.18816730654216 0.133236633829388 no 2904 0.117383750678833 4275 46368543
SGTC_2355 9061122 103.12 µM -1.19015433604428 0.132824494036514 no 2905 0.116992868611865 4283 5302957
SGTC_2762 leflunomide 42.06 µM -1.19152478264475 0.132540754864743 no 2906 0.116723816785823 4254 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_482 fipronil 114 µM -1.19199706677371 0.132443069327617 no 2907 0.116631197703551 4376 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2394 5221648 200 µM -1.19208661611648 0.132424552862989 no 2908 0.116613642166875 4315 788586
SGTC_2635 hydroquinidine 100 µM -1.19852867950196 0.131097180872506 no 2909 0.115355632412644 4196 442912 An experimental heart treatment.
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.19898196326397 0.131004130166217 no 2910 0.11526747952683 4308 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2922 7999257 32.47 µM -1.20238247016499 0.130307524744422 no 2911 0.114607688885336 4255 2988377
SGTC_1270 0831-1170 17.3 µM -1.20276090143244 0.130230160564653 no 2912 0.114534429482638 4296 6764716
SGTC_3222 9128301 49.47 µM -1.20337462871356 0.130104761477475 no 2913 0.114415690683898 4277 4911358
SGTC_2799 7812892 81.82 µM -1.20852693423573 0.129055318183962 no 2914 0.113422320991416 4315 20205235
SGTC_392 N-ethylmaleimide 8.33 µM -1.20948236538355 0.128861358894158 no 2915 0.113238791005521 4240 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2942 9052777 62.25 µM -1.20958994382943 0.128839532379614 no 2916 0.113218139402947 4348 6469503
SGTC_621 3584-0052 32.1 µM -1.20978561579141 0.128799839208641 no 2917 0.113180583566445 4318 2273927
SGTC_2004 4023728 41.89 µM -1.2097969501646 0.128797540226499 no 2918 0.113178408402635 4282 360084 YDR527W RBA50
SGTC_2210 7115885 190.385 µM -1.21048641139143 0.128657748435988 no 2919 0.113046150940433 4389 2927039
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.2130873096273 0.128131350874793 no 2920 0.112548220673562 4342 6710655
SGTC_2186 6124449 200 µM -1.21476120345283 0.127793362585326 no 2921 0.112228590923389 4295 3834182 YLR033W RSC58
SGTC_287 k060-0039 29.6 µM -1.21663155014301 0.127416440591953 no 2922 0.111872216551526 4337 5861974
SGTC_107 0358-0022 2.6945 µM -1.21675981407484 0.127390620535769 no 2923 0.111847806929885 4329 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1404 3909-7820 48.3 µM -1.22028925753543 0.126681556534019 no 2924 0.11117762033472 4278 23741373
SGTC_1037 k284-1091 78.7 µM -1.2244304613705 0.125853100169589 no 2925 0.110394941990115 4287 3334711
SGTC_1951 sophoraflavanone G 9.2 µM -1.22553048418647 0.125633674934294 no 2926 0.110187705809284 4255 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_766 1391-0721 126 µM -1.22682264930359 0.12537626353989 no 2927 0.109944628025205 4331 1020919 YIL115C NUP159
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.22859635821423 0.125023523979287 no 2928 0.109611590795902 4208 17037758
SGTC_2949 9072542 2.23 µM -1.23443843245403 0.123866607860227 no 2929 0.108519787678325 4332 16457352
SGTC_2654 protoveratrine a 100 µM -1.23589375703187 0.123579576997163 no 2930 0.108249028954949 4322 5702278 A heart drug and vasodilator.
SGTC_1685 st024049 53.0905 µM -1.23922619772498 0.122924081514985 no 2931 0.107630870626636 4333 1941139
SGTC_459 nigericin 15.3 µM -1.24233966574312 0.122313864605376 no 2932 0.107055633100092 4391 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3333 9141820 12.094 µM -1.24266809357077 0.1222496193527 no 2933 0.106995083029564 4306 1939433
SGTC_1355 1499-0035 1.68 µM -1.24277773604221 0.122228176968165 no 2934 0.106974874471965 4320 1548538
SGTC_2456 5770359 74.46 µM -1.2437364792375 0.122040791485484 no 2935 0.106798282712484 4323 3118787
SGTC_2438 5259590 200 µM -1.24376198435035 0.122035809290828 no 2936 0.106793587777208 4332 1201127
SGTC_1813 st051246 8.6015 µM -1.24381634832439 0.122025190253618 no 2937 0.106783581051734 4258 5291959
SGTC_1024 4507-0395 26 µM -1.24444199265595 0.121903028446593 no 2938 0.106668467985674 4382 4201836
SGTC_927 2425-1185 123 µM -1.24491846846987 0.121810050569234 no 2939 0.106580860714581 4252 730375
SGTC_2 0422-0095 29 µM -1.24849070235443 0.121114563796881 no 2940 0.105925705604482 4221 6790840
SGTC_623 k072-0108 16.9 µM -1.24861247677478 0.121090904578072 no 2941 0.105903423335464 4294 5382803
SGTC_1443 4112-3303 14 µM -1.25060022892658 0.120705169272015 no 2942 0.105540183526097 4363 704433
SGTC_3007 9078383 71.4286 µM -1.25268132695294 0.120302247381385 no 2943 0.105160852144345 4315 6496995
SGTC_997 3996-0078 137 µM -1.25373223153125 0.120099141923446 no 2944 0.104969674235829 4369 735687
SGTC_1540 guanosine 70.6 µM -1.25531130967506 0.119794412352361 no 2945 0.104682885568884 4245 6802 Guanosine is a purine nucleoside
SGTC_644 1498-1197 63.3 µM -1.25674063972015 0.119519051527376 no 2946 0.104423783517485 4351 6741615
SGTC_2256 7954252 200 µM -1.25674212688828 0.119518765256755 no 2947 0.10442351417304 4338 2972920
SGTC_360 0957-0399 1.01 µM -1.2583003467714 0.119219083344072 no 2948 0.10414157790566 4340 6752301 YPR165W RHO1
SGTC_376 3970-0862 59.1 µM -1.26001876319474 0.118889207332534 no 2949 0.103831296822044 4360 3135186
SGTC_2984 9022109 38.96 µM -1.26156596321852 0.118592750851666 no 2950 0.103552505103613 4366 6459207
SGTC_491 tetrandrine 80.3 µM -1.26179984666036 0.118547982315235 no 2951 0.1035104086933 4330 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1187 1391-0724 117 µM -1.26275963656609 0.11836439028032 no 2952 0.103337787280911 4376 6997986
SGTC_60 0986-0278 202 µM -1.26350793615876 0.118221392372842 no 2953 0.103203348165596 4288 3110598
SGTC_1999 st074831 12.5 µM -1.26634910533863 0.117679565635429 no 2954 0.102694061772427 4311 17112523
SGTC_1830 st055982 50.3 µM -1.2671486746393 0.117527400746045 no 2955 0.10255106696523 4313 455313 An antimicrobial agent.
SGTC_966 1300-0360 30.2 µM -1.26903410159303 0.117169139499199 no 2956 0.102214450819594 4345 70588
SGTC_3045 9092950 49.47 µM -1.26909725373709 0.11715715298849 no 2957 0.102203189830954 4327 44120432
SGTC_373 0844-0104 25.9 µM -1.27308763241438 0.116401525273165 no 2958 0.101493473548624 4365 5375804
SGTC_1006 4099-6547 255 µM -1.28136950231751 0.114844299746198 no 2959 0.100031955520325 4357 3146833
SGTC_480 am 92016 50 µM -1.28229284670353 0.11467160751813 no 2960 0.0998699681792717 4368 2129 K+ channel blocker.
SGTC_2282 7944268 200 µM -1.28293753603698 0.114551141483446 no 2961 0.0997569804569726 4354 2970414
SGTC_222 nsc-310342 10.666 µM -1.28454948192409 0.114250329050344 no 2962 0.0994748808591817 4374 432556
SGTC_395 anisomycin 6.25 µM -1.28487297231428 0.114190028896607 no 2963 0.0994183385377956 4360 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1178 0988-0033 191 µM -1.28506320114184 0.114154579919967 no 2964 0.0993850997440891 4392 5392207
SGTC_1501 4491-0275 38.4 µM -1.28982354026154 0.113270045914403 no 2965 0.0985559663435912 4344 5104718
SGTC_1141 3253-0389 52.6 µM -1.2908496979923 0.113080014530793 no 2966 0.0983779004005441 4354 5402031
SGTC_1305 1181-0477 144 µM -1.29524473281616 0.112268683961553 no 2967 0.097617908944932 4415 6252086
SGTC_1128 3448-9350 235 µM -1.29746391450749 0.111860603659561 no 2968 0.0972358067344187 4379 619386
SGTC_2270 7924575 90.91 µM -1.29838789732429 0.111691007711395 no 2969 0.0970770379214795 4332 1262135
SGTC_1090 efavirenz 20.7 µM -1.29900375499038 0.111578069977038 no 2970 0.0969713202643401 4388 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2303 7774051 200 µM -1.29941694164664 0.11150234444471 no 2971 0.0969004403462868 4372 2953184
SGTC_3077 9117319 49.47 µM -1.30029480422854 0.111341578931939 no 2972 0.0967499740803475 4332 17154678
SGTC_1210 3013-0140 750 nM -1.30110820889988 0.111192765938425 no 2973 0.0966107091604552 4385 905973
SGTC_2058 5236698 133 µM -1.30740528098084 0.110045529015228 no 2974 0.0955375523735734 4331 766665
SGTC_602 3130-1533 38.1 µM -1.31197147870497 0.109218961230158 no 2975 0.0947648790182503 4420 720941
SGTC_2798 7813637 45.45 µM -1.31515184152713 0.108645897227606 no 2976 0.0942294382790426 4373 956368
SGTC_2596 sinensetin 100 µM -1.31610627102348 0.108474342882781 no 2977 0.0940691882361236 4384 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1248 0469-0687 58.6 µM -1.31675160761966 0.108358457066568 no 2978 0.0939609493234173 4351 4017482
SGTC_2257 7960413 200 µM -1.31754889739982 0.108215407434202 no 2979 0.0938273510558406 4413 2974689 YIL048W NEO1
SGTC_964 1287-0107 19.4 µM -1.31774430102924 0.108180368888245 no 2980 0.0937946295510205 4379 51516812 YPR165W RHO1
SGTC_2778 tioconazole 65.09 nM -1.31813816279925 0.108109768901457 no 2981 0.0937287006478722 4268 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1194 1488-0194 225 µM -1.3226590204261 0.107301776645828 no 2982 0.0929743986052505 4349 1391452
SGTC_1969 st069479 40.1 µM -1.32899442607055 0.106176817341647 no 2983 0.0919249044112432 4387 3895485
SGTC_1339 1486-1321 22.7 µM -1.33025906739323 0.105953282504703 no 2984 0.0917164643139669 4411 3469382
SGTC_1981 st071826 47 µM -1.33054426631737 0.105902918486243 no 2985 0.0916695058207709 4424 11838600
SGTC_1490 4089-0339 670 nM -1.33064663412528 0.105884845309606 no 2986 0.091652655130385 4353 742542
SGTC_2823 7987624 58.44 µM -1.33330313562775 0.105416615601317 no 2987 0.0912161725535242 4360 2239440
SGTC_1754 st042065 16.137 µM -1.33586828447339 0.104965910617909 no 2988 0.0907961644699798 4152 1126236 YIL048W NEO1
SGTC_2627 acetyl isogambogic acid 100 µM -1.33683951189626 0.104795627389527 no 2989 0.0906375143486065 4397 6857789 A caspase activator and apoptosis inducer.
SGTC_3039 9090270 49.47 µM -1.33803567311297 0.10458618200647 no 2990 0.0904424041385083 4400 17173750
SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.34056897264961 0.104143607930493 no 2991 0.0900302183380333 4433 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_456 gingerol 170 µM -1.34087915542931 0.104089511622923 no 2992 0.089979845469988 4438 442793 A herb.
SGTC_2365 9042475 200 µM -1.34172096843134 0.103942800945546 no 2993 0.0898432428039512 4434 6464479
SGTC_128 0906-2981 13.371 µM -1.34199141564962 0.103895699405535 no 2994 0.0897993895289743 4379 6740226
SGTC_410 α-linolenic acid 100 µM -1.34365316222339 0.103606626591698 no 2995 0.0895302849185142 4423 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2521 angolensin 13.4 µM -1.35250985201402 0.102075782869334 no 2996 0.0881061346327339 4440 821428 A flavenoid.
SGTC_3066 9117245 49.47 µM -1.35268050128125 0.102046449296192 no 2997 0.0880788611475048 4442 17176980
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.35270520998902 0.10204220252771 no 2998 0.0880749126773203 4394 688669
SGTC_941 3237-0776 460 µM -1.35304423434453 0.101983946261246 no 2999 0.0880207496559099 4433 760008
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.35423749880663 0.101779094116097 no 3000 0.0878303095397884 4306 4330530
SGTC_416 estradiol valerate 100 µM -1.35472620555205 0.101695282531236 no 3001 0.0877524027165991 4407 13791 A steroid.
SGTC_120 rhodamine 6G 52.259 µM -1.35487885354448 0.101669114208817 no 3002 0.0877280790189211 4418 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_215 1287-0124 461.5 µM -1.35538926121837 0.101581651036945 no 3003 0.0876467846227723 4417 5560863
SGTC_2811 7967822 32.47 µM -1.35997193421193 0.100798820243623 no 3004 0.0869194027352688 4438 2232244
SGTC_2286 7945697 125 µM -1.36322724926926 0.100245412709147 no 3005 0.086405450948238 4410 1245733
SGTC_2710 st078562 53.7235 µM -1.36464262068617 0.100005490818416 no 3006 0.0861827010640876 4366 17250908
SGTC_511 blebbistatin 171 µM -1.36507665436052 0.0999320011457669 no 3007 0.0861144793651667 4467 3476986 A myosin inhibitor.
SGTC_453 enantio-paf c16 10 µM -1.36555433007367 0.0998511676918312 no 3008 0.086039444688949 4092 13871343 A lipid and platelet activating factor
SGTC_24 0417-1663 219 µM -1.36578167566484 0.0998127124928662 no 3009 0.0860037497750977 4443 4329390
SGTC_257 daunorubicin 18.5 µM -1.36833527167393 0.0993815181778169 no 3010 0.0856035775120412 4439 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1272 0839-0021 27 µM -1.36898523449034 0.0992719846908492 no 3011 0.0855019452328031 4444 5027250
SGTC_2242 6630449 61.2675 µM -1.36929422550281 0.0992199436585784 no 3012 0.0854536611546835 4447 691249 YDR170C SEC7
SGTC_2132 5317594 122.667 µM -1.37022765006165 0.0990628551411861 no 3013 0.0853079248101813 4361 794577
SGTC_397 arbidol 50 µM -1.37155080132733 0.098840490284802 no 3014 0.085101659265751 4444 131410 A RNA synthesis inhibitor.
SGTC_486 niguldipine 82 µM -1.37216968008891 0.098736608820845 no 3015 0.0850053108827066 4489 1236 A calcium channel blocker.
SGTC_409 arachidonic acid 100 µM -1.37453190678755 0.0983408334466363 no 3016 0.084638305893893 4410 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_773 4358-1457 44.6 µM -1.37456009936608 0.0983361169936509 no 3017 0.0846339329699491 4415 1186886
SGTC_627 1391-0720 175 µM -1.37573656595493 0.0981394487046596 no 3018 0.08445160340267 4386 997839
SGTC_1827 berberine 7.24 µM -1.37639511567705 0.0980294857354713 no 3019 0.0843496696712369 4317 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1039 k821-0043 94 µM -1.37939749137329 0.0975293005989944 no 3020 0.0838861161521249 4389 15992768
SGTC_2208 7283366 200 µM -1.3808054954703 0.0972953778719089 no 3021 0.0836693866760102 4413 898663
SGTC_1206 3978-0017 132 µM -1.38761889664244 0.0961692282744499 no 3022 0.0826265620999286 4481 3873677
SGTC_635 k038-0028 24.7 µM -1.38793888168602 0.0961165762753582 no 3023 0.0825778284086293 4420 4035102
SGTC_3176 9106582 49.47 µM -1.38801125241025 0.0961046709601969 no 3024 0.0825668093549197 4421 17018027
SGTC_345 1362-0200 395 µM -1.3880563638323 0.0960972504734825 no 3025 0.0825599413200815 4409 1419823
SGTC_1621 st003705 32.4 µM -1.39932614929057 0.0942566286824481 no 3026 0.0808576007912646 4429 24207032
SGTC_1419 3993-2473 62.6 µM -1.40113867090354 0.0939630449448137 no 3027 0.0805863047824546 4502 704026
SGTC_3122 9126309 49.47 µM -1.40283526697196 0.0936888502562687 no 3028 0.0803329838830512 4526 17591206
SGTC_1691 st019933 84.6 µM -1.40340387524397 0.0935970871597557 no 3029 0.0802482190322517 4416 6176082
SGTC_113 0099-0221 2.5 µM -1.40373748320548 0.0935432797670151 no 3030 0.0801985181501669 4401 89219
SGTC_3287 9117173 37.0625 µM -1.40643430753855 0.0931091493866448 no 3031 0.0797975994106536 4446 2789709
SGTC_3279 9140807 49.47 µM -1.40682552021212 0.0930462964825227 no 3032 0.0797395665768732 4484 45595718
SGTC_411 enrofloxacin 100 µM -1.40720258095298 0.0929857469373841 no 3033 0.0796836632723048 4475 71188 A bacterial gyrase inhibitor.
SGTC_327 1273-0057 3.96 µM -1.40970872659776 0.0925840425520589 no 3034 0.0793128534539776 4341 3108138
SGTC_1694 st024011 44.9 µM -1.41010003691275 0.0925214363573635 no 3035 0.0792550731948388 4487 2787533
SGTC_2215 7188065 200 µM -1.41550004812758 0.0916606782057196 no 3036 0.0784609671530331 4489 940217
SGTC_959 1222-0044 107 µM -1.42118207746469 0.090761387913925 no 3037 0.0776319168204522 4440 6083612
SGTC_1032 k061-1018 98.7 µM -1.42604239964892 0.0899973582014897 no 3038 0.0769280518163811 4495 4005393
SGTC_2930 9013230 14.89 µM -1.43111745435948 0.0892046845149815 no 3039 0.0761982778404882 4440 2995857
SGTC_3300 9124615 50.48 µM -1.43120153857294 0.089191595277502 no 3040 0.0761862313719125 4478 24824903
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.4382990830444 0.0880918782722892 no 3041 0.0751746059797274 4458 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2143 5623677 140.463 µM -1.44357491050984 0.0872809971311977 no 3042 0.0744292933167143 4416 5375313
SGTC_3206 9114350 49.47 µM -1.44486600296621 0.0870834109274801 no 3043 0.0742477636337652 4323 17087243
SGTC_754 3474-0146 171 µM -1.44781761462461 0.0866329573156353 no 3044 0.0738340325634022 4454 24762078
SGTC_2374 9071832 200 µM -1.44911691302163 0.086435220754143 no 3045 0.0736524677769775 4406 17381698
SGTC_2249 haloperidol 116.36 µM -1.45297368977094 0.0858502563855486 no 3046 0.0731155295828175 4421 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2815 7968870 71.43 µM -1.45908269066564 0.0849297642434838 no 3047 0.0722711748699935 4402 2977326 YHR190W ERG9
SGTC_1331 1472-0049 76.2 µM -1.4599507046236 0.0847995762102016 no 3048 0.0721518112096903 4442 24051409
SGTC_713 1488-1073 324 µM -1.45995346897059 0.0847991618420974 no 3049 0.0721514313161211 4512 3312542
SGTC_2544 sphondin 68.51 µM -1.46326918560787 0.084303237211436 no 3050 0.0716968680011792 4433 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2877 9040724 71.43 µM -1.4650783277589 0.0840335671094982 no 3051 0.0714497743819327 4438 6463895
SGTC_1785 bathophenanthroline 24 µM -1.46652072982258 0.0838190276028398 no 3052 0.0712532389874512 4398 72812 An iron chelator.
SGTC_1411 3909-8223 150 µM -1.46691267378446 0.0837608019181731 no 3053 0.071199906193789 4502 X1411
SGTC_1012 4112-3522 18 µM -1.46838302074999 0.0835426436024569 no 3054 0.0710001055373183 4486 3112398
SGTC_2646 retinol 96.75 µM -1.46883546422493 0.0834755996423825 no 3055 0.0709387111903999 4473 445354 A vitamin A analog and teratogen.
SGTC_1843 st055809 45.5 µM -1.47146901970751 0.0830861567057258 no 3056 0.0705821598999175 4515 16413835
SGTC_2639 lactacystin 53 µM -1.47442918922346 0.0826500478509903 no 3057 0.0701830350894249 4499 3870 A proteasome inhibitor.
SGTC_853 0419-0306 21 µM -1.47543120539457 0.0825028161404212 no 3058 0.0700483254837022 4485 762713
SGTC_1887 st057648 70.8 µM -1.47690690601763 0.0822863430223181 no 3059 0.0698502967404795 4475 688672
SGTC_1368 1852-0141 284 µM -1.48158257277461 0.0816032858649764 no 3060 0.0692256994524188 4461 2838987
SGTC_1427 4048-4900 550 nM -1.48298498824649 0.0813992460383352 no 3061 0.0690391996223557 4464 24132586
SGTC_922 1866-0035 480 µM -1.48524478952347 0.0810712736346687 no 3062 0.0687394956049948 4417 3156169
SGTC_1811 st050069 61.5 µM -1.48610252453363 0.0809470491713569 no 3063 0.0686260023279568 4480 3877702
SGTC_510 ag-490 170 µM -1.48686740747173 0.080836393575781 no 3064 0.0685249169466463 4621 5328779
SGTC_1794 st048918 76.9 µM -1.48797384715871 0.0806765271173453 no 3065 0.0683788954106825 4461 672303
SGTC_2133 5320837 200 µM -1.49176539378689 0.0801305076811742 no 3066 0.0678803295240028 4506 2841355
SGTC_1923 st058458 19.1 µM -1.49183837118361 0.080120025698449 no 3067 0.0678707610398412 4482 3534982
SGTC_1911 st060208 74.3 µM -1.49259103492735 0.0800119786031428 no 3068 0.0677721357509506 4506 688783
SGTC_1295 1013-0063 9.78 µM -1.4989073814925 0.0791095860443655 no 3069 0.0669488305911723 4502 6826038
SGTC_1758 st042942 75.2445 µM -1.50377791889183 0.0784190296659321 no 3070 0.0663192792627329 4470 669317
SGTC_3015 9080845 49.47 µM -1.50782696614938 0.077848433122989 no 3071 0.0657994092930365 4555 5296973
SGTC_1661 st013063 9.66 µM -1.50963984562898 0.0775939835207133 no 3072 0.0655676741419491 4568 721395
SGTC_3163 9099914 49.47 µM -1.51182790431401 0.077287716638023 no 3073 0.0652888243416722 4592 16268368
SGTC_1241 0364-0022 50.8 µM -1.51225560019438 0.0772279586446853 no 3074 0.0652344257247423 4499 4563895
SGTC_171 k064-0041 9.68 µM -1.51383015706413 0.0770082628407236 no 3075 0.0650344609183898 4485 53325
SGTC_604 1000-0114 314 µM -1.51521834781208 0.0768149647433031 no 3076 0.0648585590500705 4506 1572745
SGTC_821 1114-0266 29.2 µM -1.51664921135703 0.0766161109938648 no 3077 0.0646776367995103 4525 3123235
SGTC_3035 9091303 49.47 µM -1.51712755684893 0.0765497204958173 no 3078 0.0646172410003557 4580 25237002
SGTC_592 k241-0073 46.5 µM -1.51798154985511 0.0764313019644862 no 3079 0.0645095249502133 4532 4230158
SGTC_662 k832-1615 104 µM -1.51894708194076 0.0762975848407057 no 3080 0.0643879082969094 4520 5878478
SGTC_1766 st045414 44.774 µM -1.52404899054462 0.0755939724202423 no 3081 0.06374823681148 4518 253960
SGTC_2766 oltipraz 83.91 µM -1.52518675182417 0.0754377382401816 no 3082 0.0636062620178179 4486 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2306 7482397 179.52 µM -1.52624162384892 0.075293106140266 no 3083 0.063474850419176 4497 891448
SGTC_999 SEC7.066 22.7 µM -1.52773057119099 0.0750893184361175 no 3084 0.0632897232506758 4455 740511 YDR170C SEC7
SGTC_137 0438-0332 85.389 µM -1.52824559067496 0.0750189272752816 no 3085 0.0632257866213068 4452 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_389 tpck 16.7 µM -1.53059325764144 0.0746986933525048 no 3086 0.0629349745601415 4548 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3018 9082602 49.47 µM -1.53173158137568 0.0745437961176922 no 3087 0.0627943428606513 4430 17332089
SGTC_984 1492-0255 2.91 µM -1.53256411667158 0.0744306643161978 no 3088 0.062691644247957 4473 1585198
SGTC_897 1000-0139 31.4 µM -1.54106491973801 0.073282995956938 no 3089 0.0616504933094526 4477 6151020
SGTC_261 5-fluorouridine 15.376 µM -1.54173930520387 0.0731925319689827 no 3090 0.0615684782311622 4535 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3161 9100388 49.47 µM -1.54352235838434 0.0729537597410103 no 3091 0.0613520434734907 4594 25236368
SGTC_406 estrone 100 µM -1.54650119458446 0.0725561885073996 no 3092 0.0609917859022672 4519 5870 A steroid.
SGTC_1896 st058441 89 µM -1.5492616616451 0.0721892454723741 no 3093 0.0606594159636475 4540 688759
SGTC_1209 2323-2347 50.3 µM -1.5501713810012 0.0720686305282727 no 3094 0.0605501934709744 4539 5412760
SGTC_36 0335-0881 14.2 µM -1.55284978516393 0.0717144118745495 no 3095 0.0602295128180652 4417 23828853
SGTC_2733 amorolfine 100 µM -1.55419501765073 0.0715370095963754 no 3096 0.0600689528063787 4679 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3008 9078912 71.4286 µM -1.55532400489983 0.0713883846758262 no 3097 0.0599344615426525 4550 16648731
SGTC_1033 k072-0102 21.3 µM -1.55563519799751 0.0713474595226302 no 3098 0.0598974319760977 4480 5965931
SGTC_2285 7945142 200 µM -1.55921478236165 0.0708780007400054 no 3099 0.0594727766250899 4532 2970608
SGTC_1184 1269-1718 139 µM -1.56676532326483 0.0698955409847151 no 3100 0.0585847777961009 4587 5403821
SGTC_612 0302-0167 22.4 µM -1.56907836484936 0.0695966795831629 no 3101 0.0583148401537562 4531 235821
SGTC_1482 3346-2049 8.48 µM -1.57639203992483 0.068658172695986 no 3102 0.0574677408621965 4571 3826804
SGTC_451 chloral hydrate 100 µM -1.57646469726632 0.0686488983534754 no 3103 0.0574593742194018 4509 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1010 4112-3296 15.2 µM -1.57680137103037 0.0686059362591739 no 3104 0.0574206180476587 4562 704384
SGTC_3223 9129970 49.47 µM -1.57760758033562 0.0685031421993746 no 3105 0.0573278949209279 4552 17248386
SGTC_234 nsc-17383 10.7 µM -1.57907308278952 0.0683165906581312 no 3106 0.0571596474505167 4536 408974
SGTC_1642 st009582 77.7 µM -1.58560637543609 0.0674896994770051 no 3107 0.0564143145528442 4526 6739311
SGTC_21 0849-0113 22.993 µM -1.5882513325262 0.0671571462869177 no 3108 0.0561147588349218 4519 1560156
SGTC_1289 0976-0073 69.1 µM -1.59043843108705 0.0668831183645239 no 3109 0.0558680067122911 4589 3391136
SGTC_896 0964-0007 44.5 µM -1.59090707372667 0.0668245134594055 no 3110 0.0558152451945805 4504 6756758
SGTC_1118 chelidonine 707.474 nM -1.5918875741217 0.0667020280209948 no 3111 0.0557049840211597 4537 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1371 2421-0008 32.7 µM -1.59441771751039 0.0663867616899642 no 3112 0.0554212533474726 4538 2827552
SGTC_3203 9113543 49.47 µM -1.59614508301078 0.0661721883955454 no 3113 0.0552282026220265 4543 17018012
SGTC_883 0850-0245 24.6 µM -1.60028421183641 0.0656602119954818 no 3114 0.0547677738526017 4587 6823229 YPR165W RHO1
SGTC_1056 3448-1962 115 µM -1.60578567122639 0.0649844865450423 no 3115 0.0541605049994849 4509 715507
SGTC_2546 rhodinyl acetate 100 µM -1.6194613459015 0.0633281380014636 no 3116 0.052674018423944 4512 6708682
SGTC_3294 9122953 26.2835 µM -1.62791574996652 0.0623207282171771 no 3117 0.0517713756593987 4536 16459826
SGTC_2841 9004761 38.96 µM -1.63311428174252 0.0617075144351225 no 3118 0.0512224817168538 4505 2991039
SGTC_2936 9038235 15.59 µM -1.6378004391554 0.0611587863868467 no 3119 0.0507316649763251 4486 4749415
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.63780344498674 0.0611584356452672 no 3120 0.050731351359065 4583 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1679 SEC14.276 6.7 µM -1.63979584672048 0.0609262938268636 no 3121 0.0505238110259243 4523 1005053 YMR079W SEC14
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.64371737776959 0.0604713951813723 no 3122 0.0501172973398562 4514 676296 Flavone; oxidizing agent.
SGTC_774 k060-0086 136 µM -1.65061171765519 0.059678097917264 no 3123 0.0494089423376537 4577 5911235
SGTC_1619 st003326 88.7 µM -1.65115179041968 0.0596163004811054 no 3124 0.0493537921535249 4547 2849032
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.65135553733806 0.0595929999190631 no 3125 0.0493329990625666 4595 688788
SGTC_2426 5582046 32.21 µM -1.65283741593918 0.0594237464683965 no 3126 0.0491819784812097 4560 2251934
SGTC_2333 9017922 200 µM -1.6553013192463 0.0591431650446946 no 3127 0.048931695738123 4554 3163164
SGTC_1629 st005085 44.9 µM -1.65538322675588 0.0591338555554985 no 3128 0.0489233931015348 4528 24207091
SGTC_901 1112-0062 60.1 µM -1.65907285128228 0.058715688895101 no 3129 0.0485505565782366 4561 1908457
SGTC_2323 6148992 148.28 µM -1.66100783136257 0.0584973160258423 no 3130 0.0483559369392794 4531 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2621 lithochol-11-enic acid 100 µM -1.66314772034874 0.058256561236757 no 3131 0.0481414347879922 4520 6708711
SGTC_2703 st077852 53.4 µM -1.66422636969027 0.0581354998960804 no 3132 0.0480336001214963 4595 6281836
SGTC_2339 9000433 200 µM -1.66609399832668 0.0579263556207498 no 3133 0.0478473468724818 4540 2988954
SGTC_1562 morin hydrate 59.1 µM -1.66797324324473 0.0577165079009736 no 3134 0.0476605192254977 4575 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1605 st000082 49.1 µM -1.66857488921934 0.0576494509849703 no 3135 0.0476008294044632 4541 1114022
SGTC_2529 gangaleoidin 93.61 µM -1.66931539179771 0.0575670018273747 no 3136 0.0475274457160507 4555 4565183
SGTC_2086 5274770 176.623 µM -1.67007048356301 0.0574830238110209 no 3137 0.0474527095936525 4607 689278
SGTC_778 3456-2434 196 µM -1.67329441703739 0.0571255556056424 no 3138 0.0471346754949832 4496 5539063
SGTC_2207 7258803 200 µM -1.67742065878186 0.0566705955348271 no 3139 0.0467301262017984 4604 3666799
SGTC_1678 st019265 80.2 µM -1.67957722961718 0.0564339501208706 no 3140 0.0465198005338899 4561 5367020
SGTC_1675 st018485 24.5 µM -1.68137568899843 0.0562371972503121 no 3141 0.0463449822904017 4567 3323024
SGTC_2612 dictamnine 15.46 µM -1.68317833234689 0.0560405297623075 no 3142 0.0461702870210925 4504 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2371 9071574 200 µM -1.68378560776009 0.0559743986021379 no 3143 0.0461115548204174 4585 45596039
SGTC_705 1124-0212 310 µM -1.6847076666356 0.0558741058149176 no 3144 0.04602249331152 4569 9554485
SGTC_135 0933-0004 26.348 µM -1.68505380492804 0.0558364928064537 no 3145 0.0459890955688362 4501 21230617 YGL099W LSG1
SGTC_1385 3091-4834 14.1 µM -1.68962022030265 0.0553421527332311 no 3146 0.0455503174905885 4574 4072814
SGTC_2928 9011484 9.79 µM -1.68962587946462 0.0553415422485054 no 3147 0.0455497758083577 4563 2994751
SGTC_539 4859-0462 2.54 µM -1.69079044579058 0.0552160272231235 no 3148 0.0454384162980147 4600 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1771 st048882 4.1505 µM -1.69291305489622 0.0549878344410151 no 3149 0.0452360090058963 4596 4580403
SGTC_1237 0330-0133 46.1 µM -1.6930405192301 0.0549741550402317 no 3150 0.0452238774151187 4529 X1237 YHR072W ERG7
SGTC_1100 amiodarone 5.07 µM -1.70595806962298 0.0536017409581859 no 3151 0.0440079433592723 4620 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_3345 9148410 3.559 µM -1.70605398346862 0.0535916531340571 no 3152 0.0439990145456458 4542 4903596
SGTC_2397 5161689 200 µM -1.71127776547683 0.0530445051700746 no 3153 0.0435149244413999 4596 2259942
SGTC_83 0170-0301 39.027 µM -1.71290045101364 0.0528754469712862 no 3154 0.0433654276521732 4615 3089716
SGTC_2880 9042983 58.44 µM -1.71508912539136 0.0526480990083498 no 3155 0.0431644438900905 4547 6464714
SGTC_1527 coumarin 137 µM -1.71765916054233 0.0523821283035116 no 3156 0.0429294012938694 4621 323 A hepatotoxic, DNA x-linker.
SGTC_2428 5615643 7.78 µM -1.72856719589529 0.0512651179778825 no 3157 0.0419432924857886 4595 2253075
SGTC_1044 1222-0021 1.78 µM -1.73308803936017 0.0508077627167487 no 3158 0.0415400109540076 4529 4306703
SGTC_2878 9043973 25.97 µM -1.73580695230476 0.0505342696990062 no 3159 0.0412989872093519 4611 6465167
SGTC_806 3966-4455 5.86 µM -1.73769104078677 0.0503454398029444 no 3160 0.0411326341080501 4592 714982
SGTC_610 4215-0184 155 µM -1.7382457197553 0.0502899552164885 no 3161 0.0410837631185533 4614 5605015
SGTC_1795 st049545 62.3 µM -1.73862843184064 0.05025170091384 no 3162 0.041050071041179 4569 5291882
SGTC_3121 9125696 49.47 µM -1.73896963814543 0.0502176149159083 no 3163 0.0410200518246289 4689 1235365
SGTC_97 0535-0701 19.132 µM -1.74097671129636 0.0500174842117946 no 3164 0.0408438304035273 4522 2832013 YGL099W LSG1
SGTC_1779 st039427 55 µM -1.7444666371028 0.0496710090922945 no 3165 0.0405388770456915 4598 1124498
SGTC_2516 gossypol 71.55 µM -1.74668496197873 0.0494517741138261 no 3166 0.0403460001613869 4613 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_810 3825-7150 143 µM -1.74759292975179 0.0493622635763757 no 3167 0.0402672702481658 4615 22330411 YGL099W LSG1
SGTC_252 miconazole 1.30953 nM -1.74772753025609 0.049349005218752 no 3168 0.0402556096615186 4531 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1387 3342-1166 1.8 µM -1.7488829698107 0.0492353095595096 no 3169 0.0401556254713807 4611 3418228
SGTC_1112 tnp00069 1.16933 µM -1.75099707043535 0.0490278228902469 no 3170 0.0399732073215573 4591 145826
SGTC_2344 7990960 76.95 µM -1.7541424169553 0.0487204187907896 no 3171 0.0397030535525485 4591 140813
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.75664036672387 0.0484773859265253 no 3172 0.0394895639523455 4572 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_256 clotrimazole 625 nM -1.75709775932247 0.0484329900460338 no 3173 0.0394505737991267 4555 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2095 5432005 200 µM -1.7677150265266 0.0474115542160341 no 3174 0.0385542783076836 4634 783734
SGTC_2522 biochanin a 4.94 µM -1.77216489725992 0.0469886193804638 no 3175 0.0381835943557117 4605 5280373 A possible chelator.
SGTC_2759 disulfiram 3.38 µM -1.780255352289 0.0462274222883645 no 3176 0.0375170901867719 4522 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1432 4049-0298 68.4 µM -1.78324140530819 0.0459489913897703 no 3177 0.0372735075231504 4647 741646
SGTC_255 tunicamycin 200.472 nM -1.78373712447778 0.0459028993336009 no 3178 0.0372331953258311 4547 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_586 0957-0265 8.15 µM -1.78717690984814 0.0455840899270659 no 3179 0.0369544500091652 4545 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1930 st074634 34.3 µM -1.79145943891473 0.0451896631285434 no 3180 0.0366097989777003 4538 684253 YOR116C RPO31
SGTC_1643 st009866 20.2 µM -1.79165907086938 0.0451713439490632 no 3181 0.036593797283037 4609 3156273 YOR207C RET1
SGTC_1829 berberine 14.4 µM -1.79410954090662 0.0449469636357364 no 3182 0.0363978432530637 4577 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2214 7179297 48.276 µM -1.79559161050051 0.0448116920876026 no 3183 0.0362797455658468 4684 769744
SGTC_714 4296-0578 26.1 µM -1.7975475862294 0.0446336681363128 no 3184 0.0361243653524358 4659 1589775
SGTC_550 4123-0385 25.7 µM -1.79878626433896 0.0445212242287583 no 3185 0.0360262484633905 4645 5731123
SGTC_618 k072-0232 33.2 µM -1.7992288407161 0.0444811037007697 no 3186 0.0359912445295263 4654 5872756 YGL099W LSG1
SGTC_2846 9008642 19.48 µM -1.80238474947293 0.0441958573500565 no 3187 0.0357424464575662 4621 2992898
SGTC_1712 st032288 53.4 µM -1.80726460550214 0.0437576968901327 no 3188 0.0353605159615075 4415 2883011
SGTC_1555 citronellol 128 µM -1.81171247944426 0.0433613832851486 no 3189 0.0350153171749566 4616 8842 A terpine precursor.
SGTC_3023 9089636 49.47 µM -1.81218107525259 0.0433197998342608 no 3190 0.0349791111150098 4691 17249241
SGTC_49 0717-0965 32.132 µM -1.818319409919 0.042778048634777 no 3191 0.0345076639182758 4671 5889349 YGL099W LSG1
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.82963679802964 0.0417935728508759 no 3192 0.0336521336993504 4684 688664
SGTC_2464 5717415 7.67 µM -1.83409643637306 0.0414107127634494 no 3193 0.0333198401642551 4601 5285744
SGTC_1498 4478-3555 97.6 µM -1.83635799637221 0.0412176467357941 no 3194 0.033152363734606 4651 3437919
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.8541054564838 0.039727780966309 no 3195 0.0318620371166426 4631 688803
SGTC_1293 1000-1278 195 µM -1.85486906267423 0.0396646732728205 no 3196 0.0318074634087248 4661 678847
SGTC_1660 st012960 28.1 µM -1.85576565948636 0.0395906787377377 no 3197 0.0317434836623976 4668 24207266
SGTC_110 0850-0284 111.64 µM -1.86517544534514 0.0388208579458535 no 3198 0.0310784080847293 4607 3906265
SGTC_3220 9131269 49.47 µM -1.86552936103633 0.0387921434707258 no 3199 0.0310536203141443 4647 17722206
SGTC_572 0960-0087 17.7 µM -1.87318091993433 0.0381755633838029 no 3200 0.030521703073337 4626 6796365
SGTC_1688 st021091 57.6 µM -1.87378109558073 0.0381275398277569 no 3201 0.0304803015234247 4696 3656366
SGTC_3292 9120825 59.784 µM -1.87997374130748 0.0376349015648857 no 3202 0.030055828366317 4628 24824900
SGTC_2952 9073731 13.78 µM -1.88884469541735 0.0369382641765965 no 3203 0.0294563209078319 4624 16457353
SGTC_509 pifithrin 175 µM -1.89680465176091 0.0363221751038013 no 3204 0.0289268625819504 4718 4817 A p53 inhibitor.
SGTC_2268 7933382 153.85 µM -1.90124143405677 0.0359824415158517 no 3205 0.028635198122429 4676 935025 YOR257W CDC31
SGTC_2601 securinine 100 µM -1.90547623636651 0.0356606060275323 no 3206 0.0283590967955513 4614 442872 A GABA receptor antagonist.
SGTC_3304 9125678 46.087 µM -1.91034911831742 0.03529320126675 no 3207 0.0280441387301987 4627 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2569 tetrandrine 100 µM -1.91685116049765 0.0348078025617914 no 3208 0.027628421623459 4642 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1478 0453-0656 35.7 µM -1.91869360504713 0.0346712590345513 no 3209 0.0275115606557705 4698 5258496
SGTC_1556 plumbagin 1.48 µM -1.9187609784386 0.0346662743427862 no 3210 0.0275072951770783 4603 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1351 1496-0003 46.5 µM -1.9253957633305 0.0341782680130719 no 3211 0.0270899326127375 4677 3891978
SGTC_1674 st016616 23.6 µM -1.93144975177157 0.0337379220271787 no 3212 0.0267137288069984 4644 625830
SGTC_1115 galangin 695.678 nM -1.93381810006159 0.0335669317952287 no 3213 0.0265677482812778 4717 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2275 7947463 200 µM -1.93547540350687 0.0334477023801503 no 3214 0.0264659920683085 4635 1225414
SGTC_2165 5727197 32.143 µM -1.93672476221494 0.0333580519312367 no 3215 0.0263894985854946 4663 1361712
SGTC_1489 4065-0444 182 µM -1.93736582543629 0.0333121279162176 no 3216 0.0263503205073227 4671 2877968
SGTC_454 lyso-paf C-16 6.67 µM -1.93766775561806 0.0332905165074211 no 3217 0.0263318851276822 4664 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2784 7567673 72.73 µM -1.93922321607948 0.0331793634291623 no 3218 0.0262370819250788 4598 3471247
SGTC_1884 5633444 25 µM -1.94091100166365 0.0330591004333628 no 3219 0.0261345366668444 4611 5724239
SGTC_875 0709-0210 25.7 µM -1.94271640530282 0.0329308544024694 no 3220 0.0260252164786958 4664 6251364
SGTC_1191 1487-1166 10.6 µM -1.94309904977312 0.0329037261546848 no 3221 0.0260020959121764 4673 3955771
SGTC_1962 st076595 64.5 µM -1.94961164815509 0.0324448220222675 no 3222 0.0256112120005244 4634 279619
SGTC_2969 9091408 28.7 µM -1.9499960563485 0.0324179009239472 no 3223 0.0255882945432943 4617 4286311
SGTC_2686 alizarin 95.37 µM -1.95241781299321 0.0322487225457521 no 3224 0.0254443099440871 4646 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_346 4513-0042 7.16 µM -1.95299793443024 0.0322083049562493 no 3225 0.0254099199744334 4635 2827372
SGTC_1382 3002-2117 298 µM -1.95840890931137 0.0318333275496643 no 3226 0.0250910250904645 4696 1497314
SGTC_771 0250-0039 27.3 µM -1.97404786384093 0.0307697841597607 no 3227 0.0241881503714545 4634 3005115
SGTC_923 1900-2434 73.3 µM -1.97937789481771 0.0304141003006383 no 3228 0.0238867376981023 4644 5910570
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.98459814209453 0.0300690512323093 no 3229 0.0235945996114845 4686 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3302 9125395 16.351 µM -1.98844504374207 0.0298168603477971 no 3230 0.0233812456451211 4647 17599668
SGTC_3079 9117512 49.47 µM -1.99170975815642 0.0296042145977605 no 3231 0.02320145621747 4736 7185044
SGTC_2552 juarezic acid 87.02 µM -1.99303560090197 0.029518216517942 no 3232 0.0231287744321139 4655 1549512
SGTC_2487 5918373 44.05 µM -2.00644801756046 0.0286598516468773 no 3233 0.0224042347972725 4697 2876279
SGTC_354 2783-3500 4.88 µM -2.01516984881025 0.028112890111534 no 3234 0.021943427783276 4678 6740761
SGTC_3186 9110464 49.47 µM -2.01708588374424 0.0279939038220065 no 3235 0.0218432757524104 4691 17018021
SGTC_2137 5261020 140 µM -2.01913255080063 0.027867268826784 no 3236 0.0217367222190441 4667 763655
SGTC_2322 7413319 38.22 µM -2.02319515008949 0.0276173141127005 no 3237 0.0215265157570886 4615 1840400
SGTC_1226 3909-7979 35.4 µM -2.02366111203017 0.0275887652562163 no 3238 0.0215025162149544 4676 6615510
SGTC_568 1193-0097 7.48 µM -2.02432489935945 0.0275481383929712 no 3239 0.0214683666621451 4507 3646150
SGTC_877 0771-0151 33.1 µM -2.02831838913141 0.0273047695958819 no 3240 0.0212638816699633 4699 6166523
SGTC_2704 st078022 71.1 µM -2.03754750025942 0.0267491896897372 no 3241 0.0207976034816214 4711 54697681
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -2.04133143542296 0.0265241467101825 no 3242 0.0206089472505303 4678 4000243
SGTC_4 0960-0234 25.671 µM -2.04167315410184 0.0265039016942488 no 3243 0.0205919817229716 4644 6821112
SGTC_1509 1326-1131 80 µM -2.04357741944139 0.0263913204022875 no 3244 0.020497655948199 4684 768313
SGTC_310 1273-0058 1.06 µM -2.04553200874895 0.0262761798672277 no 3245 0.0204012184259281 4351 2734232
SGTC_2279 7948423 32.93 µM -2.06495032017312 0.0251549344641715 no 3246 0.0194638505793297 4651 1247112
SGTC_700 3453-2283 142 µM -2.07502123265277 0.0245893935729628 no 3247 0.0189922834875362 4719 565664
SGTC_2401 5128683 200 µM -2.07534147792691 0.0245715863967347 no 3248 0.0189774489239403 4667 708373
SGTC_2777 climbazole 1.536 µM -2.08900469987635 0.0238218641630167 no 3249 0.0183536500507654 4491 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2640 pentamidine 10.38 µM -2.10500040775915 0.0229686817177724 no 3250 0.017645636283882 4666 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2671 danthron 100 µM -2.11034501456043 0.0226894088160214 no 3251 0.0174143244588788 4693 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2981 9013952 38.96 µM -2.11750919742739 0.0223195513534675 no 3252 0.0171083277738316 4652 2996344
SGTC_548 1436-0017 110 µM -2.11753632048268 0.0223181608234924 no 3253 0.01710717808162 4727 9677137
SGTC_1879 gemcitabine 100 µM -2.13150912536878 0.0216114616835653 no 3254 0.0165236107366857 4690 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2511 berberine 10.47 µM -2.13760153642959 0.0213092994539707 no 3255 0.0162745484721037 4704 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3169 9102970 49.47 µM -2.13906875855355 0.0212370665413157 no 3256 0.0162150500753921 4752 17027839
SGTC_895 0964-0006 13.7 µM -2.13973052814339 0.0212045547466476 no 3257 0.016188275210806 4713 6738897
SGTC_3064 1327-0027 10 µM -2.15526470320699 0.0204533899531994 no 3258 0.015570563108723 4709 16000455 YPR107C YTH1
SGTC_1240 0356-0016 42.1 µM -2.17084676196421 0.0197226860041428 no 3259 0.0149713788963743 4695 4305613
SGTC_64 000l-0018 272.079 µM -2.17821991419293 0.0193847281848946 no 3260 0.01469483407847 4637 6811119
SGTC_2357 9067248 200 µM -2.186073015515 0.0190301951360015 no 3261 0.0144051319239881 4678 9150235
SGTC_1727 st034309 9.9045 µM -2.18783904543293 0.0189512305448103 no 3262 0.0143406643131033 4712 870305
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -2.19209491814711 0.0187620817818983 no 3263 0.014186326812922 4736 91467 include heat shock
SGTC_2021 4019055 173 µM -2.21048619098766 0.0179630618967748 no 3264 0.0135357189240021 4535 44827708 YER133W GLC7
SGTC_2230 bromochlorosalicylanilide 954.5 nM -2.21423618269679 0.0178037525573544 no 3265 0.013406268025605 4758 77254
SGTC_3110 9122132 49.47 µM -2.22153347415187 0.0174971975957288 no 3266 0.0131574250367323 4728 918317
SGTC_237 nikkomycin 200 µM -2.2270517457295 0.017268381032551 no 3267 0.0129719078296518 4732 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_658 3253-0951 102 µM -2.23289202493875 0.0170290015197432 no 3268 0.0127780328158496 4734 1184878
SGTC_1734 st037168 69.4 µM -2.26782068564604 0.0156557799856092 no 3269 0.0116700690439382 4719 708907
SGTC_1718 roemerine 11.9335 µM -2.27646593595105 0.0153309426040655 no 3270 0.011409068584157 4384 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1298 1079-1278 263 µM -2.297046597437 0.0145808499303018 no 3271 0.0108080558375813 4717 2840950
SGTC_2541 muurolladie-3-one 83.07 µM -2.30088948811478 0.0144443460300055 no 3272 0.0106989392178782 4703 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2597 laccaic acid a 100 µM -2.32979128683023 0.0134525305171357 no 3273 0.00990859245600754 4707 5491415 A textile dye.
SGTC_1968 st069590 43.6 µM -2.33229821869303 0.0133693402638336 no 3274 0.00984250408988592 4724 6384066
SGTC_1588 farnesol 29.9 µM -2.33535758723148 0.0132684201325066 no 3275 0.0097623740611568 4753 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1860 st056228 74.6 µM -2.34395431583943 0.0129883530168536 no 3276 0.00954025417291495 4739 688679
SGTC_1005 4092-0690 4.4 µM -2.3501214011675 0.0127906014446846 no 3277 0.00938364445017939 4726 1529343
SGTC_280 3448-3607 3.04 µM -2.35352411975466 0.0126826101705912 no 3278 0.00929820068178305 4736 626179
SGTC_299 1273-0059 1.44 µM -2.3536018810985 0.0126801515270448 no 3279 0.00929625604248036 4534 2848077
SGTC_298 1391-0729 10 µM -2.36221150324626 0.0124104726407666 no 3280 0.00908313734484388 4723 3237558
SGTC_1677 st019204 53.9 µM -2.37386654459513 0.0120533247308382 no 3281 0.00880145577856507 4738 3945625
SGTC_2968 9090663 33.37 µM -2.38338239612872 0.0117683702887346 no 3282 0.00857718231547005 4707 25236811
SGTC_116 0155-0182 31.788 µM -2.39667941036177 0.0113799893032518 no 3283 0.00827219593608072 4662 771486
SGTC_522 1273-0010 11.6 µM -2.40099351291744 0.0112563983689906 no 3284 0.00817531317795824 4743 5705015
SGTC_706 4262-0057 46.9 µM -2.40101692466873 0.0112557308618914 no 3285 0.00817479014639964 4745 883298
SGTC_2649 anisomycin 9.56 µM -2.40384727882443 0.0111752859614989 no 3286 0.00811177468067643 4769 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1378 2093-0007 380 nM -2.40621376741403 0.0111084093180726 no 3287 0.00805941487643715 4743 3618014
SGTC_2719 novobiocin 32.65 µM -2.44359054247186 0.0100973905559522 no 3288 0.00727096008396445 4760 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_663 1486-0733 13.9 µM -2.44641886385785 0.010024262017832 no 3289 0.00721416340860577 4761 722445 YPR165W RHO1
SGTC_674 0498-0004 451 µM -2.44819000257496 0.00997870352773237 no 3290 0.00717879600526986 4741 4231473
SGTC_564 3555-0129 330 µM -2.44898708273718 0.00995825950772908 no 3291 0.007162929283791 4751 563260
SGTC_2336 9001819 198.65 µM -2.46158735553282 0.00963990372923958 no 3292 0.00691618542003204 4723 2989602
SGTC_3141 9094609 49.47 µM -2.47840842556819 0.00922878926159589 no 3293 0.00659849913815747 4736 25236309 YDL196W YDL196W
SGTC_3113 9123498 49.47 µM -2.49590718651172 0.00881747696753245 no 3294 0.00628177346701999 4789 8897275
SGTC_1098 clofazimine 15.1 µM -2.49896104869561 0.00874736614048846 no 3295 0.0062279000441383 4773 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2871 9038510 12.99 µM -2.53713808153546 0.00791128074947798 no 3296 0.00558814310707078 4737 4945164
SGTC_617 3770-0098 35 µM -2.55523145488955 0.00754018720013087 no 3297 0.00530586046218776 4729 5962639
SGTC_1855 st056195 39.6 µM -2.55636315067107 0.0075174941906579 no 3298 0.00528863335204669 4728 4028379
SGTC_2675 theaflavin digallate 100 µM -2.58086214356582 0.00704076572918888 no 3299 0.00492769640785162 4732 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2887 9044784 58.44 µM -2.58835185932637 0.00690044793922405 no 3300 0.00482182087414998 4710 6465546
SGTC_1108 betulinic acid 729.144 nM -2.61597045740384 0.00640413127090184 no 3301 0.00444871277050059 4741 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2297 7971671 152.32 µM -2.62184927089791 0.00630265853518118 no 3302 0.00437270499084617 4754 909016
SGTC_1707 st032323 6.317 µM -2.63628724297011 0.00605946522833825 no 3303 0.00419093723059362 4636 3132057 YMR211W DML1
SGTC_1934 st074720 32.6 µM -2.6522167949827 0.00580083024344178 no 3304 0.00399825897482329 4732 17250992
SGTC_1522 st012842 45.6 µM -2.6620038231882 0.00564682809321162 no 3305 0.0038838498095835 4690 3491067 YOR116C RPO31
SGTC_1450 4112-4260 37.6 µM -2.66723584061886 0.00556599876042204 no 3306 0.00382389918948859 4757 1633175
SGTC_1786 berberine 21.6 µM -2.68724208626755 0.00526632012737295 no 3307 0.00360223582104583 4715 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1310 1188-0297 994 nM -2.70296714472783 0.00504093522856086 no 3308 0.00343617695250215 4730 1588352
SGTC_1560 lithocholic acid 53.1 µM -2.70809793582528 0.00496927759350925 no 3309 0.00338350251020664 4769 9903 A bile acid which acts as a detergent.
SGTC_1507 4075-3230 155 µM -2.71730609725655 0.00484294723812002 no 3310 0.00329078537528711 4756 659771
SGTC_1036 k216-0215 33.5 µM -2.72682924946296 0.00471531446443883 no 3311 0.0031973060151181 4757 622330
SGTC_1003 4049-0218 100 µM -2.72950440970821 0.00468000495713861 no 3312 0.00317148003864987 4774 295161
SGTC_158 k038-0087 26.446 µM -2.73044500031933 0.00466764624255314 no 3313 0.0031624442903106 4729 X158
SGTC_2520 obtusaquinone 4.71 µM -2.73978633603151 0.0045464790992008 no 3314 0.00307395684316781 4782 5967872
SGTC_2659 sanguinarine 24.21 µM -2.75823303589398 0.0043154229668681 no 3315 0.00290573761317626 4768 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_690 glyoxal 20.3 µM -2.76293221234022 0.0042582662719568 no 3316 0.00286423311154454 4673 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_689 0833-0039 98 µM -2.76351701224336 0.00425120084265828 no 3317 0.00285910557070794 4754 5374726
SGTC_703 3875-0075 71.8 µM -2.76990132250662 0.00417474610634719 no 3318 0.00280366388845368 4790 2850814
SGTC_3100 9120536 49.47 µM -2.77249850660913 0.00414399736394292 no 3319 0.0027813887328143 4744 16421196
SGTC_2701 st077767 14.721 µM -2.78169271074548 0.0040367666109812 no 3320 0.00270381074861772 4768 5721188
SGTC_2325 6158266 200 µM -2.80140239062725 0.00381522444450499 no 3321 0.00254405154468712 4761 3623240
SGTC_3103 9120822 49.47 µM -2.80236747106121 0.00380466206920974 no 3322 0.00253645271992388 4782 17141819
SGTC_1749 st037932 54.2 µM -2.81372558988313 0.00368230774726987 no 3323 0.00244855060200557 4759 594497
SGTC_217 ketoconazole 989 nM -2.82223959503223 0.00359291868628768 no 3324 0.00238447669356894 4684 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1774 st048371 48.465 µM -2.85216797837913 0.00329395009689032 no 3325 0.00217110739391228 4779 4242727
SGTC_1959 st077091 55.8 µM -2.85281088496333 0.00328778081080088 no 3326 0.0021667200981258 4784 821356 YKL052C ASK1
SGTC_153 4077-0274 519.67 µM -2.89251877206981 0.00292630606945285 no 3327 0.00191083171862017 4775 3121976
SGTC_547 1120-0019 610 nM -2.89901863228229 0.00287067336742349 no 3328 0.00187166324302267 4780 3676939
SGTC_12 0849-0099 9.267 µM -2.93209622559938 0.0026020659133044 no 3329 0.00168341205223576 4782 6071388
SGTC_1323 1348-1351 11.2 µM -2.97788348564261 0.00226769878134096 no 3330 0.00145123149011454 4779 6989654
SGTC_659 k018-0002 107 µM -3.04838238749005 0.00182844484657146 no 3331 0.00115038477474658 4777 6797879 YHR007C ERG11
SGTC_3137 9097352 49.47 µM -3.07154839268295 0.00170196360245894 no 3332 0.00106475821062536 4760 44120435
SGTC_1979 st071809 45.3 µM -3.08679951529991 0.00162309984435185 no 3333 0.00101162001761592 4799 4976333
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -3.14017774190977 0.00137259089927687 no 3334 0.000844226791555424 4794 803109
SGTC_3032 9089427 49.47 µM -3.14410938496056 0.00135561483939165 no 3335 0.000832965776207209 4776 17173707
SGTC_657 3534-0529 86.7 µM -3.18982340574959 0.00117183608257291 no 3336 0.000711798776035664 4801 1049549
SGTC_868 0527-0199 213 µM -3.20857684579714 0.00110327584787749 no 3337 0.000666968283347587 4790 2849450
SGTC_1905 st060207 84.5 µM -3.21626457105978 0.00107624849882017 no 3338 0.000649355213580475 4792 1948547
SGTC_513 4245-1575 41.7 µM -3.22092229787645 0.00106017025788999 no 3339 0.000638893932981728 4726 719745
SGTC_2648 atorvastatin 78.68 µM -3.24618686478761 0.000976731742726663 yes 3340 0.000584810198050411 4795 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2904 7225135 42.03 µM -3.24815290777605 0.000970498476797593 yes 3341 0.000580784150914029 4790 4446116
SGTC_3197 9113331 49.47 µM -3.31481033888878 0.000779583429327588 yes 3342 0.000458526612124809 4773 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2973 9094665 17.96 µM -3.40452194911948 0.000577001348269311 yes 3343 0.00033139986734705 4782 25237061 YIL048W NEO1
SGTC_3266 9136860 49.47 µM -3.49986376234367 0.000415859991677783 yes 3344 0.000232747999630562 4699 4871271 YPR165W RHO1
SGTC_2913 7966556 36.57 µM -3.52109193874425 0.000386197600653703 yes 3345 0.000214886789109369 4787 2976516
SGTC_2253 7938677 135.83 µM -3.74859338228374 0.000170459525493424 yes 3346 8.89145627413951e-05 4806 2301972
SGTC_2781 5567276 71.43 µM -3.76044244904472 0.000163147651910173 yes 3347 8.48065471853315e-05 4790 2853274
SGTC_73 0327-0325 16.231 µM -3.85857826907626 0.000112932913953531 yes 3348 5.70242721822537e-05 4762 53298
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -3.89366762068544 9.88101932169729e-05 yes 3349 4.93699594054861e-05 4804 364106
SGTC_304 1310-0298 97 µM -3.91363008872848 9.15343271285321e-05 yes 3350 4.54594413115336e-05 4743 1550234
SGTC_514 4466-0038 2.65 nM -3.99898635447567 6.57393677619101e-05 yes 3351 3.18071736062765e-05 4770 5722064
SGTC_725 1497-0963 19 µM -4.38007048358433 1.38607111824564e-05 yes 3352 5.93204637268362e-06 4809 3549977
SGTC_2677 mitomycin C 100 µM -4.78029471683582 2.35128127002339e-06 yes 3353 8.75192040655501e-07 4810 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2611 pyromycin 23.93 µM -4.96034110895315 1.01014947640289e-06 yes 3354 3.51847502743835e-07 4808 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2607 solasodine 47.35 µM -4.98122869337148 9.14114445613398e-07 yes 3355 3.15909092655483e-07 4804 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -7.50369339690482 2.88672976381489e-13 yes 3356 3.10221659769914e-14 4810 6708739 YPR165W RHO1