SGTCid condition conc unit TPP1|YMR156C.score TPP1|YMR156C.strain.pval TPP1|YMR156C.strain.significant TPP1|YMR156C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1136 pergolide 1.05886 µM 7.79317676585362 1.65621642455595e-15 yes 1 3.26725521231408e-15 2 47811 A dopamine receptor agonist.
SGTC_2307 7538926 6.34 µM 7.78580381670608 1.75800397511418e-15 yes 2 3.4635684054395e-15 4 96582
SGTC_878 0828-0289 13.7 µM 7.60689312955719 7.34985791896469e-15 yes 3 1.40381641739953e-14 8 745350 YLR208W SEC13
SGTC_2315 7733312 200 µM 6.26763039014848 1.182573662905e-10 yes 4 1.83291816280006e-10 5 726316
SGTC_1291 0993-0025 5.79 µM 6.25493316327202 1.28519845061667e-10 yes 5 1.98843093795106e-10 1 4353356
SGTC_874 0599-0792 117 µM 6.19939817521208 1.84596881921018e-10 yes 6 2.83397363824265e-10 5 765305
SGTC_671 0560-0003 407 µM 6.0492614938894 4.83781492429589e-10 yes 7 7.27556553559246e-10 1 3238678
SGTC_2818 7996756 12.99 µM 6.03493553437188 5.29741167966419e-10 yes 8 7.95130799331251e-10 2 2241621
SGTC_1266 0828-0227 32.9 µM 5.9509717486042 8.98007269738859e-10 yes 9 1.33277549114474e-09 2 3913820
SGTC_3327 9140648 26.9345 µM 5.83183077531428 1.87620801883815e-09 yes 10 2.74112520203045e-09 3 8029710
SGTC_1254 0550-0035 264 µM 5.49208480926357 1.41921692541469e-08 yes 11 1.98608275526098e-08 5 15121435
SGTC_1445 4239-0156 97.7 µM 5.3500035567267 3.19705034491329e-08 yes 12 4.39762516499854e-08 4 4008346
SGTC_702 1488-0190 94 µM 5.25488776162865 5.44496297915159e-08 yes 13 7.40573851852417e-08 2 949357
SGTC_530 4358-1714 28 µM 4.83432649552532 5.14946894865164e-07 yes 14 6.67985832802084e-07 20 1564641
SGTC_686 1319-0111 510 µM 4.79686707313089 6.23715987055267e-07 yes 15 8.05832375877655e-07 14 4562600
SGTC_2702 st077768 96.8 µM 4.6423076230682 1.3552271876117e-06 yes 16 1.72269689977729e-06 8 6484119
SGTC_2679 rapamycin 1 nM 4.33347885654485 5.95408770688387e-06 yes 17 7.33856913269538e-06 125 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_947 3447-0010 211 µM 4.1068565027821 1.66203032493442e-05 yes 18 2.00540112492729e-05 10 748350
SGTC_2059 5238311 157 µM 4.09420721799416 1.75743725165272e-05 yes 19 2.11807665428907e-05 20 703021
SGTC_18 0111-0177 500 nM 4.09116682471113 1.78113263117495e-05 yes 20 2.14604116823302e-05 69 721752
SGTC_1844 rapamycin 4 nM 4.06769047886197 1.97458397771941e-05 yes 21 2.37406961474387e-05 153 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2561 acetosyringone 100 µM 4.0087457184941 2.55198168281316e-05 yes 22 3.05210509324936e-05 18 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2874 9043904 71.43 µM 3.94302005982865 3.38343724931925e-05 yes 23 4.02309612029052e-05 10 4463428
SGTC_3067 9117431 49.47 µM 3.9374731134583 3.46426572950938e-05 yes 24 4.11720774219027e-05 8 17150885
SGTC_2764 methyldopa 94.69 µM 3.92186657886259 3.70159332796757e-05 yes 25 4.39328221388062e-05 17 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_773 4358-1457 44.6 µM 3.90179599172869 4.029453231947e-05 yes 26 4.77408072343672e-05 47 1186886
SGTC_158 k038-0087 26.446 µM 3.8737459688998 4.53389400887946e-05 yes 27 5.35875649062644e-05 147 X158
SGTC_1664 st014217 9.02 µM 3.86699289167874 4.66395342439266e-05 yes 28 5.50928191725381e-05 10 3982782
SGTC_1651 st011928 86.1 µM 3.84310553183978 5.15284459868084e-05 yes 29 6.07435986830842e-05 15 720198
SGTC_767 0929-0023 86 µM 3.83674371685912 5.29098303556767e-05 yes 30 6.23382308213471e-05 82 1204563
SGTC_1646 st011709 75.6 µM 3.78509273542894 6.54913975642783e-05 yes 31 7.68256356377209e-05 14 5757843
SGTC_1267 0828-0272 9.49 µM 3.76689585809583 7.0559619476269e-05 yes 32 8.26449543616991e-05 24 745334
SGTC_2816 7982706 58.44 µM 3.76068446314416 7.23726077358821e-05 yes 33 8.47245328534689e-05 60 2981853
SGTC_2610 ononetin 44.17 µM 3.74765576871392 7.63189005526837e-05 yes 34 8.9247494053473e-05 53 259632
SGTC_1029 k015-0030 64.7 µM 3.67763727995281 0.000101233322755216 yes 35 0.000117702193727401 38 2208316
SGTC_957 1187-1561 14.1 µM 3.67476321065547 0.000102403666766623 yes 36 0.000119035052155874 31 1538454
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 3.66697532452863 0.000105639157054213 yes 37 0.000122718234507959 39 551469
SGTC_2401 5128683 200 µM 3.61828561234333 0.000128146533129507 yes 38 0.000148280508400342 52 708373
SGTC_3187 9109394 49.47 µM 3.61611060765828 0.00012925003126181 yes 39 0.000149531315299977 34 17098090
SGTC_2969 9091408 28.7 µM 3.60840514221878 0.000133231546898985 yes 40 0.00015404255931026 40 4286311
SGTC_1354 1498-1681 81 µM 3.59516349077224 0.000140343434804882 yes 41 0.000162093962285051 28 5754243
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 3.57080380308224 0.000154364571203357 yes 42 0.000177943702671943 23 688669
SGTC_2873 9040596 71.43 µM 3.56610989642206 0.00015721277882631 yes 43 0.000181159742018467 64 6463863
SGTC_1721 st082152 9.2685 µM 3.55156015496239 0.000166357119024332 yes 44 0.000191477221481325 29 5296051
SGTC_1974 st069448 26.9 µM 3.51005120285742 0.000195254822144794 yes 45 0.000224010206059943 39 6323587 YNR016C ACC1
SGTC_786 4544-0069 423 µM 3.45203777374545 0.000243561955374619 yes 46 0.000278184915822712 52 748821 YLR208W SEC13
SGTC_2625 euphol 100 µM 3.41524012134349 0.000279753730171891 yes 47 0.000318629034125276 52 6708538 A triterpene alcohol.
SGTC_1873 rapamycin 2 nM 3.37917128530889 0.000320037409637278 yes 48 0.000363523474479255 91 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3077 9117319 49.47 µM 3.34445922596778 0.000363843216461328 yes 49 0.000412215735983865 30 17154678
SGTC_1326 1431-2094 10.8 µM 3.33435358985568 0.000377606462748386 yes 50 0.000427489485890369 54 616278
SGTC_1610 st001799 48.1 µM 3.31693682730312 0.000402467240561289 yes 51 0.00045505096109939 31 621897
SGTC_1718 roemerine 11.9335 µM 3.12598938934205 0.000794384730422068 yes 52 0.000886039727542658 108 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2353 9059630 146.67 µM 3.12162418913919 0.000806500073861457 yes 53 0.00089928185636604 40 4779114
SGTC_974 1326-0144 138 µM 3.11468502587532 0.00082610979588588 yes 54 0.00092070713283877 81 5411856
SGTC_1645 Cervolide 78 µM 3.10826565950675 0.000844640309190986 yes 55 0.000940944113648474 25 23173 A fragrance.
SGTC_2268 7933382 153.85 µM 3.10389210350555 0.000857483439638408 yes 56 0.000954964844891594 66 935025 YOR257W CDC31
SGTC_539 4859-0462 2.54 µM 3.06947881977977 0.000964980680975734 yes 57 0.00107216304888827 56 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2907 7721985 69.9 µM 3.04340181865861 0.00105453137022493 no 58 0.00116959879159994 76 3267881
SGTC_2412 st077135 33.4 µM 3.04189900255593 0.00105991742428325 no 59 0.00117545380047023 67 13258915
SGTC_2913 7966556 36.57 µM 2.99580536147666 0.0012378834795705 no 60 0.00136860543836844 48 2976516
SGTC_943 3253-1379 105 µM 2.97864945646012 0.0013108240442087 no 61 0.0014476089692871 68 668464
SGTC_2661 dactinomycin 12.96 µM 2.97304690869587 0.00133548195175983 no 62 0.00147429692239513 68 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2716 st080858 38.6235 µM 2.96303667806948 0.00138059679245954 no 63 0.00152310134518367 53 5296050
SGTC_3037 9091026 49.47 µM 2.90755808983412 0.00165685544049158 no 64 0.00182131341760036 223 25236398 YIL048W NEO1
SGTC_3248 9135562 49.47 µM 2.90019955022539 0.00169705745357248 no 65 0.00186462581483542 37 17650701
SGTC_708 3448-5400 146 µM 2.89410699179694 0.00173101288206089 no 66 0.0019011928713413 107 3462195
SGTC_3169 9102970 49.47 µM 2.89396812902554 0.00173179395797858 no 67 0.00190203385837364 27 17027839
SGTC_2195 6536160 144.242 µM 2.88436957647796 0.00178656773908586 no 68 0.00196099089179729 55 3834386
SGTC_1795 st049545 62.3 µM 2.87992246879205 0.00181247530098866 no 69 0.00198886487760444 53 5291882
SGTC_610 4215-0184 155 µM 2.87030453400281 0.00186967887699338 no 70 0.00205038322685684 56 5605015
SGTC_532 1548-0774 215 µM 2.85786586922262 0.0019460915528612 no 71 0.00213250317067715 67 5932993
SGTC_1803 st050068 52.4 µM 2.8549534240109 0.00196438815958112 no 72 0.00215215704034642 285 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1801 st050089 28.441 µM 2.81510325090934 0.00223092095532235 no 73 0.00243807823388459 218 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 2.77824161037732 0.00250620446118634 no 74 0.00273269811948102 145 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1130 3454-2858 15.9 µM 2.77419246220666 0.00253824391506217 no 75 0.00276694643365788 157 715628 YIL048W NEO1
SGTC_221 trifluoperazine 10.304 µM 2.76388508735405 0.00262147995082553 no 76 0.00285588252501322 314 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_692 k241-0027 77.8 µM 2.74059027610003 0.00281874744699095 no 77 0.00306644658087867 60 3600480
SGTC_1378 2093-0007 380 nM 2.69312320313981 0.00326268287836354 no 78 0.00353930531169066 102 3618014
SGTC_2558 carylophyllene oxide 100 µM 2.68712778138924 0.00332301410553706 no 79 0.0036034688198886 81 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1040 k898-0338 155 µM 2.68283638930622 0.00336681181913134 no 80 0.00365003470929506 87 20969351
SGTC_1634 st006576 41 µM 2.67452784392489 0.00345308585256981 no 81 0.00374172808301181 94 3915356
SGTC_273 hydroxyurea 18.1 mM 2.67084805864507 0.00349192653113732 no 82 0.00378299429988896 105 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2339 9000433 200 µM 2.65191236932006 0.00369806794313545 no 83 0.00400186557353917 116 2988954
SGTC_310 1273-0058 1.06 µM 2.64568146994931 0.0037682491057622 no 84 0.00407632725131522 405 2734232
SGTC_2515 chrysin 20.77 µM 2.63660302171666 0.00387264149033409 no 85 0.00418703837987261 70 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_307 1501-1223 22.3 µM 2.62564567020129 0.00400208587937008 no 86 0.00432423969702476 74 2830329
SGTC_2328 6201408 200 µM 2.61688023251019 0.00410841103485425 no 87 0.00443687354387405 90 2890418
SGTC_1717 st033143 58.0435 µM 2.61494727246614 0.00413219539916554 no 88 0.00446206154674913 143 674616
SGTC_1256 0570-0116 285 µM 2.6091334589069 0.00420447654444087 no 89 0.00453859165568902 99 410638
SGTC_540 1187-0821 17.3 µM 2.60282911837242 0.00428413236545208 no 90 0.00462290123292775 100 847520
SGTC_1377 2944-0135 198 µM 2.59769041735081 0.00435005542178968 no 91 0.00469265336465023 136 1894137
SGTC_1432 4049-0298 68.4 µM 2.58865738375526 0.00446813822827461 no 92 0.00481754532247798 74 741646
SGTC_316 k060-0003 58.6 µM 2.56368607276279 0.00480960469738574 no 93 0.00517835853468992 88 6152314
SGTC_672 1441-0018 53.7 µM 2.56209922269321 0.00483207007498256 no 94 0.00520207949197648 93 251141
SGTC_2766 oltipraz 83.91 µM 2.55990185434211 0.0048633331333464 no 95 0.00523508638520135 115 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2712 st079126 47.7 µM 2.55261241024429 0.00496833869935317 no 96 0.00534592010113499 97 3152970
SGTC_2869 9037858 32.47 µM 2.54969573690492 0.00501091641410963 no 97 0.00539084844419696 82 27187042
SGTC_1120 ficusin 1.78878 µM 2.5358709451726 0.00521718368991019 no 98 0.00560840311840578 112 6199 A DNA cross-linker.
SGTC_322 k048-0136 19.3 µM 2.52655559558944 0.00536039654724687 no 99 0.00575935777706372 88 6823282
SGTC_304 1310-0298 97 µM 2.5255882293554 0.00537546721344259 no 100 0.00577523870961629 177 1550234
SGTC_1276 0871-0068 94.2 µM 2.51821338092726 0.00549160418274113 no 101 0.00589759196624216 98 3414906
SGTC_2979 9012552 45.46 µM 2.51677321992439 0.00551454188194869 no 102 0.00592175166400336 51 17100905
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 2.5127493648781 0.00557908234510109 no 103 0.00598972044987957 129 4174840
SGTC_329 k048-0121 21.3 µM 2.50069128337327 0.00577652324880097 no 104 0.0061975587683885 100 6832902
SGTC_2859 9028643 45.46 µM 2.49096967206577 0.00594019569532719 no 105 0.00636974968265365 81 17151580
SGTC_1135 dihydrocapsaicin 536.708 nM 2.4889912846716 0.00597400289535823 no 106 0.00640530530396938 148 107982 A Capsaicinoid.
SGTC_3272 9137413 49.47 µM 2.48630598063988 0.00602016293881821 no 107 0.00645384657571143 106 17614870
SGTC_1074 carmofur 3.8 µM 2.47916229221461 0.0061445048799604 no 108 0.00658456852711936 146 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 2.47488049474451 0.00622011896795559 no 109 0.00666403824708136 102 4330530
SGTC_1889 st059080 5.18 µM 2.47067804315206 0.00629513199370605 no 110 0.00674285849525954 125 176925 Isolated from Daphnopsis sellowiana.
SGTC_1214 0358-0031 63.7 µM 2.46420974548342 0.00641215537834432 no 111 0.00686578650442286 124 4301366
SGTC_2423 st077119 87.2 µM 2.44397515876218 0.00679076067791983 no 112 0.00726321335739707 117 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2997 9067075 71.4286 µM 2.44272213692868 0.00681484213979394 no 113 0.0072884778224276 174 27209819
SGTC_362 0310-0100 9.03 µM 2.43691474693542 0.00692744042750946 no 114 0.00740658564218308 152 790235
SGTC_1915 st067105 30.6 µM 2.43668735816471 0.00693188244632496 no 115 0.00741124427953405 174 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1338 1486-1223 76 µM 2.42303906648822 0.00720314879960853 no 116 0.00769563570726352 130 3444526
SGTC_2670 beta-carotene 100 µM 2.42093563928986 0.00724577766441866 no 117 0.00774030893042618 52 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1137 ixabepilone 100 µM 2.41326627926828 0.0074030980516158 no 118 0.00790513211034648 176 154225 A novel microtubule stabilizer.
SGTC_3307 9126885 69.2785 µM 2.40064562188409 0.00766854135981629 no 119 0.00818308872256417 153 24824909
SGTC_39 0986-0283 58.349 µM 2.39628824160611 0.0077621143174752 no 120 0.00828103015946719 172 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1484 3473-2379 286 µM 2.37931217313982 0.00813631925185208 no 121 0.00867248998749041 129 671917
SGTC_2998 9066762 71.4286 µM 2.37656697096059 0.00819829824886262 no 122 0.00873729446051078 162 4945196
SGTC_1800 st050079 29.0735 µM 2.37405305965764 0.00825541877969801 no 123 0.00879701099621606 336 3645560
SGTC_441 propafenone 146 µM 2.34561592141669 0.00892630725571121 no 124 0.00949783531662955 86 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_13 0199-0087 65 µM 2.34449535200699 0.00895369491831828 no 125 0.00952642400045739 105 4589825
SGTC_1474 0330-0125 5.35 µM 2.33452105320417 0.00920073680487179 no 126 0.00978422749315026 118 X1474
SGTC_2687 chenodiol 100 µM 2.31513794322056 0.0096979235887585 no 127 0.0103026920497952 141 5702181 A cholesterol synthesis inhibitor.
SGTC_1781 st038725 66.3 µM 2.30713296788451 0.00991000862929966 no 128 0.0105237042833548 254 4270275 YIL048W NEO1
SGTC_2600 tangeritin 87.95 µM 2.3052146401176 0.00996143061186891 no 129 0.0105772776713742 143 68077 A bioactive flavone.
SGTC_1594 piperine 70.1 µM 2.28900807114231 0.0104052335533323 no 130 0.0110394417196002 156 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1767 st044992 70.3 µM 2.28199225824977 0.0106026396600729 no 131 0.0112448986633184 175 9600693
SGTC_2966 9084041 48.03 µM 2.27843489303647 0.0107039750633971 no 132 0.0113503397257622 170 17741380
SGTC_2346 9031566 143.75 µM 2.27102000293059 0.010917910548053 no 133 0.0115728835360324 131 4771086
SGTC_893 0958-0369 48.9 µM 2.24697764002426 0.0116373770999546 no 134 0.0123207280745081 189 6819948
SGTC_467 ro 31-8220 72.8 µM 2.2261372352091 0.0122939781200049 no 135 0.0130024952573185 240 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_165 k038-0023 64.381 µM 2.22503717330947 0.0123295114164216 no 136 0.0130393713775678 256 46368543
SGTC_210 3551-0445 56.827 µM 2.22204584831271 0.0124265849865936 no 137 0.0131401036493727 186 2865180 YOR207C RET1
SGTC_1273 0849-0096 14.1 µM 2.220800071149 0.0124672073876871 no 138 0.0131822528862877 164 5286025
SGTC_1204 4049-0315 18.3 µM 2.20972239353656 0.0128335146711694 no 139 0.0135622173068766 178 588402
SGTC_546 peri-Naphthalide 147 µM 2.20037826449453 0.0131497005766159 no 140 0.0138900343167708 160 223824 A penicillin ester.
SGTC_179 1273-0063 6.77 µM 2.19551332955056 0.0133169686841937 no 141 0.01406339789607 144 3108139
SGTC_1545 lovastatin 49.4 µM 2.19414259603254 0.0133644283671974 no 142 0.0141125799186822 207 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1583 clindamycin 39.6 µM 2.17886968064088 0.0139031891836501 no 143 0.0146706753485295 162 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_142 0335-0849 62.6745 µM 2.17846103019556 0.0139178581474915 no 144 0.0146858652413568 335 3889043 YPR107C YTH1
SGTC_2819 7996655 46.38 µM 2.16972628805928 0.0142346075978983 no 145 0.0150137936754559 149 6456960
SGTC_1875 nocodazole 6 µM 2.16966259437682 0.0142369399516938 no 146 0.0150162078558897 177 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2053 5265679 138 µM 2.16035276681454 0.0145814096125456 no 147 0.0153726854907441 211 764595
SGTC_659 k018-0002 107 µM 2.15946671997925 0.0146145646395706 no 148 0.0154069882689307 174 6797879 YHR007C ERG11
SGTC_1180 1193-0155 285 µM 2.13349469996031 0.0156156449313358 no 149 0.016442082985813 179 2921347
SGTC_770 0389-1121 67.2 µM 2.12942533110822 0.0157777119423589 no 150 0.0166095432686594 227 6753108
SGTC_153 4077-0274 519.67 µM 2.12827652143762 0.0158237248340212 no 151 0.0166570817798348 161 3121976
SGTC_2767 sibutramine 71.45 µM 2.12441705096145 0.0159791505882857 no 152 0.0168176427256863 177 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2923 7992654 58.14 µM 2.11916207526931 0.016192877821646 no 153 0.0170383860678148 197 2985126
SGTC_91 0417-1751 58.384 µM 2.11552252229339 0.016342335010724 no 154 0.0171927187163722 258 6795624
SGTC_1813 st051246 8.6015 µM 2.1135096682113 0.0164254984812652 no 155 0.0172785841915537 145 5291959
SGTC_1910 st062352 60.4 µM 2.09449457411775 0.017229167753024 no 156 0.0181079729534857 233 2245730
SGTC_1463 k081-0032 34.1 µM 2.0921137762176 0.0173321198708783 no 157 0.0182141695481809 119 977755
SGTC_1579 chlormadinone acetate 49.4 µM 2.07835806172418 0.0179372982275776 no 158 0.0188381961892983 184 45114258 A steroidal progestin.
SGTC_389 tpck 16.7 µM 2.06270956261154 0.0186475697013081 no 159 0.019570115414161 210 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1006 4099-6547 255 µM 2.05998903654992 0.0187734635975557 no 160 0.0196997944635475 207 3146833
SGTC_3171 9103192 49.47 µM 2.03925621070236 0.019756853031707 no 161 0.0207122317506887 136 13018434
SGTC_977 1348-1378 135 µM 2.02986644568819 0.0202164113004625 no 162 0.0211850583140544 210 X977
SGTC_2865 9030313 51.95 µM 2.02728570910677 0.0203442955348067 no 163 0.0213166010798884 167 42562754
SGTC_3133 9127736 49.47 µM 2.02120616142918 0.0206482703738965 no 164 0.0216292140821321 201 27243420
SGTC_2395 5646831 180.19 µM 2.00424294329094 0.0215168350603515 no 165 0.0225220212545161 231 6808628
SGTC_8 0354-0001 70 µM 1.99888280658499 0.0217976302068271 no 166 0.0228105177253533 319 4993152
SGTC_2529 gangaleoidin 93.61 µM 1.99289330580084 0.0221150504300902 no 167 0.0231365657567714 173 4565183
SGTC_1534 6-azauridine 81.6 µM 1.99032083631031 0.0222525741145712 no 168 0.0232778020787522 256 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_132 0417-1715 25.805 µM 1.98986733174811 0.0222768930354528 no 169 0.0233027759365584 206 6769098
SGTC_424 splitomicin 100 mM 1.97786585226499 0.0229286604589252 no 170 0.0239719210645193 227 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3240 9133527 49.47 µM 1.97452404568515 0.0231129784628782 no 171 0.0241610930188 194 17617455
SGTC_1342 1486-1464 234 µM 1.97102193864457 0.0233074751011967 no 172 0.0243606832425037 220 3253938
SGTC_2005 4024620 188 µM 1.96372215022706 0.0237173143358891 no 173 0.0247811612185556 210 236743
SGTC_3352 9151559 45.5865 µM 1.96166252713397 0.0238340399360116 no 174 0.0249008936653298 218 17159339
SGTC_2394 5221648 200 µM 1.95465213697941 0.0242349670012719 no 175 0.0253120715118991 272 788586
SGTC_788 1182-0090 188 µM 1.94866515693654 0.0245818346714679 no 176 0.0256677126994213 350 5715185
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.94343284749063 0.0248883814476575 no 177 0.0259819408520563 282 6728940
SGTC_837 0091-0265 12.5 µM 1.93227206681294 0.0255529827459837 no 178 0.026662967121833 248 759367
SGTC_161 4065-0411 162.148 µM 1.9272612307842 0.0258561659857556 no 179 0.0269735412805657 323 1906281 YLR208W SEC13
SGTC_726 3448-4391 34.2 µM 1.91784177386234 0.0264342441877517 no 180 0.0275655385421331 272 1356692
SGTC_694 1315-0438 43.2 µM 1.91774431192329 0.0264402814882963 no 181 0.027571720025831 194 6793154
SGTC_2550 chrysin dimethyl ether 71.87 µM 1.91076405689433 0.0268756811849652 no 182 0.028017454340194 147 88881 An O-methylated flavonoid and antioxidant.
SGTC_2069 5228469 200 µM 1.89515346712432 0.0278710985033975 no 183 0.0290360364504791 231 2835210
SGTC_1017 4239-0030 168 µM 1.88840920347521 0.0283105533259125 no 184 0.0294855183732153 291 1149593
SGTC_2757 clomiphene 4.22 µM 1.88810383558016 0.0283305867327007 no 185 0.0295060060259279 297 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2713 st079149 53.4 µM 1.87988372070192 0.0288743095959235 no 186 0.0300619635133592 275 3103253
SGTC_398 bronopol 33.3 µM 1.87696893024951 0.0290691810305208 no 187 0.0302611761623317 261 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1936 st074407 74.3 µM 1.86298840113866 0.030019115169252 no 188 0.0312319490621854 321 809813
SGTC_800 3448-7362 155 µM 1.86234293138918 0.0300635873243594 no 189 0.0312773838545414 555 15991913
SGTC_1788 fluconazole 20 µM 1.860846935725 0.0301668698287905 no 190 0.0313828975868644 289 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2654 protoveratrine a 100 µM 1.85489565023533 0.0305806591124841 no 191 0.0318055646304482 239 5702278 A heart drug and vasodilator.
SGTC_2889 9059656 51.95 µM 1.84775096608782 0.0310836228425448 no 192 0.0323191886494886 257 3949838
SGTC_836 0330-0104 1.35 µM 1.84654223739257 0.0311693867927029 no 193 0.0324067562218285 264 46494820
SGTC_1697 st025554 27.742 µM 1.83947214430155 0.0316749665257932 no 194 0.0329228856849666 230 1269519
SGTC_2755 lomerizine 42.69 µM 1.8387560068019 0.0317265530919758 no 195 0.0329755408014692 278 3949 A calcium channel blocker.
SGTC_835 0312-0010 67.2 µM 1.83587767443539 0.0319345928312382 no 196 0.0331878751326867 233 1626196
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.83535870751958 0.0319722222755036 no 197 0.0332262788614067 289 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_206 4546-0025 72.014 µM 1.8159176075051 0.0334084593044865 no 198 0.0346915059605474 350 6620745 YIL048W NEO1
SGTC_858 0438-0351 2.77 µM 1.8128675770152 0.0336385333728886 no 199 0.0349261240361891 285 2799119
SGTC_205 1486-1330 71.903 µM 1.81104791165794 0.0337764168248902 no 200 0.035066717746212 217 4118834
SGTC_2743 auranofin 4.32 µM 1.80691540511308 0.0340912813142783 no 201 0.0353877350979821 264 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1350 1495-0454 146 µM 1.80354097638906 0.034350172616064 no 202 0.0356516480839433 329 1069057
SGTC_3209 9113616 49.47 µM 1.80173348828187 0.0344895090043631 no 203 0.0357936733045332 305 16649353
SGTC_2455 5377712 9.75 µM 1.79790173665567 0.0347864284773501 no 204 0.0360962904435532 256 2243908
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.79742192120949 0.0348237564293473 no 205 0.0361343316139776 281 165521
SGTC_1223 0764-0573 147 µM 1.79240716941331 0.0352158578192016 no 206 0.0365338836018775 326 1609797
SGTC_2999 9069765 71.4286 µM 1.78595594981488 0.0357255951236462 no 207 0.0370531953814376 290 2097066
SGTC_50 0929-0078 56.389 µM 1.7858986764878 0.0357301474598793 no 208 0.0370578326628992 303 1377751
SGTC_1261 0712-0010 12.7 µM 1.77379508080022 0.036702914052363 no 209 0.0380485260562746 331 2840123
SGTC_157 1348-1695 65.819 µM 1.77373004693503 0.0367081987564285 no 210 0.0380539069408926 394 5380510
SGTC_493 zm226600 134 µM 1.77343391619738 0.0367322704474371 no 211 0.0380784165681595 301 5240098 A potassium channel opener. YCR052W RSC6
SGTC_516 3992-2719 87.3 µM 1.76869561439506 0.0371191935485149 no 212 0.0384723422808729 269 5350887 YDR037W KRS1
SGTC_2630 antimycin a 100 µM 1.76842653840589 0.037141265486892 no 213 0.0384948116084429 339 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1181 1222-0449 220 µM 1.76818074836551 0.0371614366826729 no 214 0.0385153457770844 289 658318
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.76790594886838 0.0371839991892839 no 215 0.0385383140669376 374 368090
SGTC_2945 9067681 61.76 µM 1.76744537155849 0.0372218401489426 no 216 0.038576835068582 252 16456930
SGTC_233 rapamycin 362 pM 1.76030045086781 0.0378129062175158 no 217 0.0391784388898385 287 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_3122 9126309 49.47 µM 1.75779423468107 0.0380220398016668 no 218 0.0393912633376537 252 17591206
SGTC_2619 obliquin 87.91 µM 1.75660217475152 0.0381218429984472 no 219 0.039492821021205 453 6708593 A bioactive alkalod. YER133W GLC7
SGTC_89 0302-0250 142.109 µM 1.75096178794289 0.0385969760286443 no 220 0.0399762461858651 329 4203518 YLR208W SEC13
SGTC_2888 9058547 12.99 µM 1.74341291674051 0.0392404146263486 no 221 0.040630756824595 232 16476514
SGTC_2027 5150920 200 µM 1.73935652807762 0.0395897561743326 no 222 0.0409860349197206 283 786715
SGTC_1764 st044502 93.5 µM 1.73724983033543 0.0397721832603694 no 223 0.0411715414005713 321 8407
SGTC_2397 5161689 200 µM 1.73560598300537 0.0399150045294243 no 224 0.0413167636701719 336 2259942
SGTC_1737 st035557 69.7 µM 1.73474719215859 0.039989783876287 no 225 0.0413927967146338 252 5716916
SGTC_1839 st053978 48 µM 1.73457179137721 0.0400050709188763 no 226 0.0414083397589538 299 3788398
SGTC_413 propylparaben 100 µM 1.72745212616876 0.0406296041197362 no 227 0.0420432479863259 277 7175 A pharmaceutical preservative.
SGTC_545 4218-0007 221 µM 1.72736080639368 0.0406376657494075 no 228 0.0420514424787769 292 2840508
SGTC_902 1120-0002 2.07 µM 1.72676673683993 0.0406901413875794 no 229 0.0421047823053122 367 3280475
SGTC_2198 6589944 200 µM 1.7239647282366 0.0409383916069837 no 230 0.0423571054169666 242 5290268
SGTC_2951 9072950 58.06 µM 1.72139493849072 0.0411671465813156 no 231 0.0425895910588238 342 16488155
SGTC_265 mycophenolic acid 32.932 µM 1.71901228444434 0.0413801681796491 no 232 0.0428060675571194 334 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2545 solidagenone 89.61 µM 1.71876239724337 0.0414025610547339 no 233 0.0428288225422168 157 6708572 An anti ulcer agent
SGTC_3026 9090633 49.47 µM 1.71507618708249 0.0417340318440625 no 234 0.0431656297875032 302 25236842
SGTC_2512 diallyl trisulfide 49.23 µM 1.71359455316431 0.041867867214965 no 235 0.0433016072996348 243 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1237 0330-0133 46.1 µM 1.71306052764858 0.041916190633672 no 236 0.0433507024117135 298 X1237 YHR072W ERG7
SGTC_3336 9143619 71.43 µM 1.71103204325823 0.0421001577756294 no 237 0.0435375988660858 341 45595730
SGTC_869 0564-0080 44.1 µM 1.69922476762029 0.0431839925515232 no 238 0.0446384207062008 361 6843321
SGTC_3275 9138069 49.47 µM 1.69155597100369 0.0438999341261854 no 239 0.0453653337020466 288 17617007
SGTC_1145 3546-0597 10.2 µM 1.69052359332896 0.0439970415652659 no 240 0.045463914216502 362 875334
SGTC_3303 9125618 40.5795 µM 1.68810277130541 0.0442254281551776 no 241 0.045695751287809 413 22695467
SGTC_56 0957-0365 83.25 µM 1.6871266030655 0.044317792331353 no 242 0.045789505333924 364 6752360
SGTC_939 1165-0479 45.3 µM 1.68521111917066 0.0444994855328357 no 243 0.0459739232731639 347 1377347
SGTC_828 2074-0507 139 µM 1.68424518316972 0.044591336740206 no 244 0.0460671472216779 366 X828
SGTC_567 1080-0542 68.4 µM 1.68229061158782 0.0447776648160207 no 245 0.0462562503767457 289 5950415
SGTC_2664 lyso-paf C-16 73.48 µM 1.67926152597851 0.0450676637839407 no 246 0.0465505428681956 348 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_704 1310-0270 142 µM 1.67585434885229 0.045395664789232 no 247 0.0468833627449062 381 5718033
SGTC_254 nsc-64875 3.808 µM 1.67495977284606 0.0454821010190387 no 248 0.0469710623141135 316 56993
SGTC_1999 st074831 12.5 µM 1.67154671630419 0.0458130957114115 no 249 0.0473068696685039 351 17112523
SGTC_843 0310-0051 143 µM 1.67139656179249 0.0458277018803568 no 250 0.0473216872970555 324 2065037
SGTC_1905 st060207 84.5 µM 1.66309422474703 0.0466411467001121 no 251 0.048146787884724 318 1948547
SGTC_1023 4482-3888 16 µM 1.66033124809574 0.0469144123889214 no 252 0.048423916383256 329 3303168
SGTC_2235 salicylic acid 500 µM 1.66016930768785 0.0469304684738366 no 253 0.0484401986142657 261 338 A COX inhibitor and kinase inhibitor.
SGTC_2688 kanamycin b 96.69 µM 1.65944047955216 0.0470027849602193 no 254 0.0485135325383902 896 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2369 9071472 200 µM 1.65609684154915 0.0473356966655245 no 255 0.0488511044404834 358 17296037
SGTC_2236 dapsone 200 µM 1.65525693147567 0.0474196191720801 no 256 0.0489361956192082 342 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1053 3366-3204 134 µM 1.65260077662504 0.047685802907735 no 257 0.0492060699639769 373 3632071 YPR165W RHO1
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.65235316500256 0.0477106778973708 no 258 0.0492312885908201 320 2724278 An inhibitor of dopamine biosynthesis.
SGTC_466 geldanamycin 89.2 µM 1.64264171869262 0.0486945098521981 no 259 0.0502285418844455 231 5288382 HSP90 inhibitor.
SGTC_2835 9006588 71.43 µM 1.64255311442355 0.0487035601261488 no 260 0.0502377140954589 377 2345538
SGTC_1986 st071812 45 µM 1.64128491392954 0.0488332448748984 no 261 0.0503691430974088 289 11838594
SGTC_834 0312-0008 75.7 µM 1.6385703547309 0.0491117601214534 no 262 0.0506513852851057 401 6385573 YIL048W NEO1
SGTC_2962 9082311 13.18 µM 1.63464560521478 0.0495166832494605 no 263 0.0510616807370396 328 16459453
SGTC_2933 9026794 32.47 µM 1.62463029910783 0.0505620609342681 no 264 0.052120678540703 398 17586027
SGTC_1531 st059297 52.4 µM 1.61571861134264 0.0515069578822058 no 265 0.0530775826024457 365 7566702
SGTC_3108 9121785 49.47 µM 1.6103528804373 0.0520826194041219 no 266 0.0536604205072494 353 17140271
SGTC_663 1486-0733 13.9 µM 1.60839721539195 0.0522936990707691 no 267 0.0538741055758382 434 722445 YPR165W RHO1
SGTC_842 0271-0008 11.1 µM 1.60538579699116 0.0526200564790016 no 268 0.0542044640613324 384 1221709
SGTC_1248 0469-0687 58.6 µM 1.60508087338732 0.0526531919832039 no 269 0.0542380039591136 373 4017482
SGTC_2629 bisabolol 100 µM 1.60046116114787 0.0531572363244214 no 270 0.0547481581888782 391 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3184 9108758 49.47 µM 1.59796591272209 0.0534310730385021 no 271 0.0550252817498364 315 902885
SGTC_1965 Pectolinarigenin 58.4 µM 1.59749765204989 0.0534825858482781 no 272 0.0550774103210096 348 5320438 An anti-inflammatory.
SGTC_2283 7944793 200 µM 1.58560618798032 0.0548039880677719 no 273 0.0564143358278031 392 2970533
SGTC_187 1488-2104 32.728 µM 1.5846624946209 0.0549099487093199 no 274 0.0565215187968509 389 2852859
SGTC_3050 9093513 49.47 µM 1.57538090743767 0.0559607598092802 no 275 0.0575842743519182 352 25236664
SGTC_2278 7948257 134.34 µM 1.56979201725016 0.0566011153374826 no 276 0.0582317526679465 370 1247028
SGTC_1366 1683-0113 21.9 µM 1.56794187821275 0.0568143651513129 no 277 0.0584473486054222 361 708623
SGTC_3320 9137005 35.139 µM 1.56507404962597 0.0571461654191529 no 278 0.0587827737437773 360 4908713
SGTC_2140 5586273 200 µM 1.56472226863746 0.0571869703663594 no 279 0.0588240223424347 326 854421
SGTC_1705 st027868 56.3335 µM 1.55803267866901 0.0579673040875982 no 280 0.0596127508788381 340 292948
SGTC_2931 9014674 55.67 µM 1.55586975769678 0.0582213891916674 no 281 0.0598695330353941 407 2996810
SGTC_636 0kpi-0074 126 µM 1.55265088801932 0.0586011388547556 no 282 0.0602532806364054 362 616434
SGTC_1482 3346-2049 8.48 µM 1.54750931192982 0.0592117524439596 no 283 0.0608702403929544 371 3826804
SGTC_2902 5787006 60.46 µM 1.54610846451619 0.0593789790504108 no 284 0.0610391874409331 398 591003
SGTC_1876 myriocin 605 nM 1.54118664134081 0.0599694604411659 no 285 0.0616356838870828 384 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1086 cerivastatin 2.18 µM 1.53679574293986 0.060500117978079 no 286 0.0621716681249527 363 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1954 st077032 68.9 µM 1.53187212626569 0.0610995185574916 no 287 0.0627769965481507 365 698907
SGTC_1985 st071382 65.5 µM 1.52728352072001 0.0616623039212369 no 288 0.0633452627289917 386 6123237
SGTC_1417 3966-0327 90.4 µM 1.52176461895585 0.0623445409258347 no 289 0.0640340348594202 445 651118
SGTC_377 3970-0964 33.1 µM 1.51658680842201 0.0629899513777638 no 290 0.0646855190123592 514 16481235
SGTC_928 2764-0428 58.7 µM 1.51253625130534 0.0634984693132612 no 291 0.0651987488378613 452 662578
SGTC_3085 9117376 49.47 µM 1.50762016325187 0.0641199337183389 no 292 0.0658258845990231 407 16480349
SGTC_1475 4092-1048 11.7 µM 1.50451291128215 0.0645151673885944 no 293 0.0662246757198833 449 2881759
SGTC_2171 5739187 198.077 µM 1.5038914290547 0.0645944448208919 no 294 0.0663046621276288 357 2262761
SGTC_576 1073-0113 22.7 µM 1.4994145690108 0.0651677591176188 no 295 0.0668830581805406 598 5439563
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.49775919531659 0.065380746220349 no 296 0.067097912958116 502 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_913 3487-1245 167 µM 1.49588499414834 0.0656225398483703 no 297 0.0673418136789657 444 4016153
SGTC_3189 9110682 49.47 µM 1.49396460441692 0.065871010905522 no 298 0.0675924354735579 420 17122418
SGTC_2830 7992007 71.43 µM 1.4920659472235 0.0661173862601235 no 299 0.0678409289316203 399 1952075
SGTC_3079 9117512 49.47 µM 1.49037889820736 0.0663369011269476 no 300 0.0680623188740836 370 7185044
SGTC_86 0417-1630 471.922 µM 1.48562097967428 0.066959030957669 no 301 0.0686897012919123 578 3634867
SGTC_411 enrofloxacin 100 µM 1.48554885289383 0.0669684966264281 no 302 0.0686992461787885 404 71188 A bacterial gyrase inhibitor.
SGTC_1233 0325-0408 14.2 µM 1.4781198097996 0.0679490133740097 no 303 0.0696878563248719 437 12874
SGTC_1362 1611-0397 101 µM 1.47747137670823 0.068035119620444 no 304 0.0697746627293975 428 27816
SGTC_3 0833-0587 95.581 µM 1.47719288014083 0.068072127380789 no 305 0.0698119708903771 415 5382644
SGTC_801 0866-0028 10.1 µM 1.47173382610444 0.0688006908054717 no 306 0.0705463846941327 467 6849771
SGTC_2720 fluspirilene 36.88 µM 1.46640718734753 0.0695173629390254 no 307 0.0712686947233945 368 3396 An atypical antipsychotic.
SGTC_1171 0368-0077 21.4 µM 1.46298267002713 0.0699811414581885 no 308 0.0717360605108251 400 3239779
SGTC_21 0849-0113 22.993 µM 1.46246116062382 0.070051977280046 no 309 0.0718074400373211 465 1560156
SGTC_299 1273-0059 1.44 µM 1.46215874136492 0.0700930796850278 no 310 0.0718488574175016 428 2848077
SGTC_1227 3909-8010 46.6 µM 1.46153811428329 0.0701774884504041 no 311 0.071933911852304 422 15982272
SGTC_1314 1222-0010 41.1 µM 1.45960981709919 0.0704402465561001 no 312 0.0721986698234349 424 3526027
SGTC_849 0386-0493 241 µM 1.45926019163439 0.0704879689300372 no 313 0.072246753785259 416 726119
SGTC_1735 st034310 56.75 µM 1.45850828237536 0.0705906855130191 no 314 0.0723502469464804 457 871153
SGTC_766 1391-0721 126 µM 1.45827481560041 0.0706226022638218 no 315 0.0723824045296042 435 1020919 YIL115C NUP159
SGTC_45 0kpi-0036 14.9 µM 1.45668851669789 0.0708397556078356 no 316 0.0726011905176865 412 2795021
SGTC_31 0508-1974 57.237 µM 1.45431103881058 0.0711661759640541 no 317 0.0729300456814961 449 6810525
SGTC_266 formosanin C 406 nM 1.45175085974595 0.071518970735332 no 318 0.0732854459896088 468 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1319 1306-0155 43.7 µM 1.45123692500559 0.0715899528322958 no 319 0.0733569490686496 508 3122360
SGTC_2263 7948595 193.29 µM 1.44620596884339 0.0722876604823826 no 320 0.0740597200371448 377 2971371
SGTC_984 1492-0255 2.91 µM 1.44446734227848 0.0725299860470347 no 321 0.0743037798500262 420 1585198
SGTC_2705 st078069 42.8 µM 1.44035997843493 0.0731049314543301 no 322 0.0748827901945899 427 1530061
SGTC_1466 k213-0079 57.5 µM 1.43715830524481 0.0735555128240356 no 323 0.0753365086274727 478 3657981
SGTC_1638 st008370 60.6 µM 1.42961802164679 0.0746250669223694 no 324 0.0764133401409702 485 24207134
SGTC_2324 6149169 200 µM 1.42835935532712 0.0748047531107209 no 325 0.0765942258088633 420 2888231
SGTC_2782 7736369 71.43 µM 1.42764185292611 0.0749073307920746 no 326 0.0766974852761389 498 2950836 YOL077C BRX1
SGTC_42 0133-0086 60.653 µM 1.42670493587358 0.0750414385676256 no 327 0.0768324811629183 419 162923 Model of phenazepam hydroxylation.
SGTC_599 1935-0052 86.5 µM 1.42632465219922 0.0750959235597374 no 328 0.0768873259273635 483 9557311
SGTC_2684 capsaicin 100 µM 1.42600432042792 0.0751418423707309 no 329 0.0769335474775789 444 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2484 5809818 12.04 µM 1.42186077372139 0.0757377412794138 no 330 0.0775333363086539 453 2870548
SGTC_1752 st044819 83.042 µM 1.42152417323798 0.0757863066893505 no 331 0.0775822155818182 468 441209 YML126C ERG13
SGTC_626 0214-0009 33 µM 1.41728068150178 0.0764006024835274 no 332 0.0782004404988856 479 3437874
SGTC_2250 alverine citrate 130 µM 1.41654319417845 0.0765077478608713 no 333 0.0783082634638859 627 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1471 k673-0312 37 µM 1.4165090899173 0.0765127054405566 no 334 0.0783132523399574 453 24099884
SGTC_402 epigallocatechin gallate 10 µM 1.41107868851248 0.0773052193264379 no 335 0.0791107065747714 504 65064 An antioxidant.
SGTC_2039 Aminomethylbenzodioxan 200 µM 1.40957954687038 0.0775250989535169 no 336 0.0793319349265432 408 15053
SGTC_381 3461-2219 42.7 µM 1.40200759624247 0.078642942300358 no 337 0.0804564891699523 494 2883159
SGTC_1818 st052136 56.3 µM 1.4019659191139 0.0786491287001503 no 338 0.0804627120357224 486 674169
SGTC_1207 2099-0101 141 µM 1.40036510041262 0.0788870275904314 no 339 0.0807020076440131 517 5837381
SGTC_2540 epiandrosterone 100 µM 1.39758122954059 0.0793020384991187 no 340 0.0811194291244975 630 441302 A steroid.
SGTC_84 0443-0269 128.823 µM 1.39666819153427 0.0794385107076208 no 341 0.0812566868379944 489 6150058
SGTC_2505 galangin 7.89 µM 1.39476250054958 0.0797239277723904 no 342 0.0815437352516062 407 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2023 5144124 124 µM 1.39301894035317 0.0799857412887967 no 343 0.0818070316289281 471 2830192
SGTC_2185 6113692 200 µM 1.39002658117495 0.0804365893525819 no 344 0.0822604029111568 445 874150
SGTC_2051 5263410 176 µM 1.38976327381684 0.0804763526518344 no 345 0.0823003869172542 501 227584
SGTC_3140 9094243 49.47 µM 1.3896478919416 0.0804937816974997 no 346 0.0823179126097204 484 19291112
SGTC_2000 st075254 36.4 µM 1.38962525487039 0.0804972014820362 no 347 0.0823213513508214 434 17234175
SGTC_102 gallobenzophenone 83.616 µM 1.38927622213621 0.0805499437846043 no 348 0.0823743857373804 510 70837
SGTC_3059 1327-0034 3 µM 1.38639980060619 0.080985593969316 no 349 0.0828124286543012 503 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2035 5154463 94.595 µM 1.38431908010709 0.0813018376402966 no 350 0.0831303871156736 516 2769623
SGTC_1768 st044301 37.178 µM 1.38384011547611 0.0813747660453683 no 351 0.0832037083358361 508 3931349
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.38348666805741 0.0814286145056978 no 352 0.0832578462095798 511 688751
SGTC_2104 5389443 200 µM 1.38340112244247 0.0814416515993326 no 353 0.0832709532916891 549 2244536
SGTC_1672 st016598 6.51 µM 1.38337792690021 0.0814451868555083 no 354 0.0832745075211613 506 4665860 YNL267W PIK1
SGTC_126 0417-1624 672.48 µM 1.3787250216143 0.0821566835109469 no 355 0.083989775876272 613 41912 YDL195W SEC31
SGTC_1919 st067113 52.3 µM 1.37557620805553 0.0826408324949776 no 356 0.0844764384140956 515 1268243
SGTC_1016 4226-1401 38 µM 1.37457856836342 0.0827946726627852 no 357 0.0846310683532705 504 2901613
SGTC_3315 9136395 68.55 µM 1.37455188675688 0.0827987900334651 no 358 0.0846352068024314 516 16876844
SGTC_698 k064-0052 127 µM 1.3734955965046 0.0829619152133203 no 359 0.0847991646181323 425 5088751
SGTC_1666 st014829 29 µM 1.37162703956935 0.0832510723743303 no 360 0.0850897859134776 520 3858230
SGTC_2447 5741742 33.78 µM 1.37015105090074 0.0834800151720267 no 361 0.0853198772826896 506 1776504
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.36855052376381 0.0837288097035531 no 362 0.08556990932662 463 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1003 4049-0218 100 µM 1.36579179995207 0.084158947361627 no 363 0.0860021604460043 529 295161
SGTC_621 3584-0052 32.1 µM 1.36559099037614 0.0841903220501008 no 364 0.0860336880049477 521 2273927
SGTC_2802 7925815 54.55 µM 1.36254741591423 0.0846669286850844 no 365 0.0865125954325895 532 1262923
SGTC_276 colchicine 750 µM 1.36072173054759 0.0849537900770722 no 366 0.0868008223186427 535 2833 A microtubule depolymerizer.
SGTC_1001 4048-4355 44.4 µM 1.35949633372984 0.0851467391590812 no 367 0.0869946817340843 484 21824233
SGTC_2345 9052315 157.45 µM 1.35242416663198 0.0862667328090451 no 368 0.0881198314049597 499 6469265
SGTC_3278 9139605 49.47 µM 1.34999218469638 0.0866544120779137 no 369 0.0885092448884129 509 7958859
SGTC_2036 5160441 105 µM 1.34740921959786 0.0870675837255797 no 370 0.0889242364487515 590 134534 YIL048W NEO1
SGTC_473 2-arachidonoylglycerol 10 µM 1.34169719633249 0.0879865019081064 no 371 0.0898470982334398 520 5282280 An endocannabinoid.
SGTC_562 3772-2733 112 µM 1.33445663061509 0.0891616925014754 no 372 0.0910271255895747 603 2876874 YIL048W NEO1
SGTC_1368 1852-0141 284 µM 1.33058679217605 0.0897945624669673 no 373 0.0916625053914163 510 2838987
SGTC_3335 9143315 29.6265 µM 1.32915793705399 0.0900290782953339 no 374 0.0918979345529057 508 4899691
SGTC_3287 9117173 37.0625 µM 1.32637237175392 0.0904875768123303 no 375 0.0923581927697167 441 2789709
SGTC_3137 9097352 49.47 µM 1.3261417261251 0.0905256181988685 no 376 0.092396378620429 574 44120435
SGTC_2425 5628681 7.85 µM 1.32452701760148 0.09079227166781 no 377 0.0926640381307789 623 5714958
SGTC_203 k066-0004 30.888 µM 1.31861562565345 0.0917734539747959 no 378 0.0936488235624577 629 6795412
SGTC_1826 st055655 41.6 µM 1.31264217980049 0.0927728929661629 no 379 0.094651774712829 561 676168
SGTC_819 1013-0258 27.7 µM 1.30781208546397 0.0935869011092957 no 380 0.0954685270171119 541 5753198
SGTC_2589 lobaric acid 100 µM 1.30726939244093 0.0936786888711997 no 381 0.0955606177122768 524 73157 A novel microtubule depolymerizer.
SGTC_1465 k213-0056 144 µM 1.30581060168415 0.0939257492127301 no 382 0.0958084869327471 521 24048857 YMR208W ERG12
SGTC_211 3455-0679 143.504 µM 1.30538842914797 0.093997337859714 no 383 0.0958803081910364 562 748649
SGTC_781 4335-2806 94.4 µM 1.30000260455046 0.0949141588811359 no 384 0.0968000382482201 626 845254
SGTC_218 alverine citrate 93.75 µM 1.29793850184117 0.0952672688264571 no 385 0.0971542341756684 520 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2347 9049783 174.81 µM 1.29374761239289 0.0959871860714119 no 386 0.0978763067257519 604 6467988 YPL169C MEX67
SGTC_1867 st057372 64 µM 1.29351866290101 0.0960266302916269 no 387 0.09791586676665 556 688837
SGTC_655 k060-0012 42 µM 1.29319880332825 0.0960817567743311 no 388 0.0979711547246844 558 5994525
SGTC_1283 0922-0125 16.4 µM 1.29274906141872 0.0961593072978305 no 389 0.0980489316316442 593 3360884
SGTC_270 tamoxifen 5.46 µM 1.29247886551624 0.0962059202155727 no 390 0.0980956801844952 589 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1518 st038567 90.8 µM 1.2894390475406 0.0967314802375325 no 391 0.0986227468949827 509 77966
SGTC_219 mitoxanthrone 164.414 µM 1.28937396170024 0.096742756065523 no 392 0.0986340545950938 558 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_223 busulfan 5 mM 1.28707062686964 0.0971424202042605 no 393 0.0990348361592007 446 2478 A DNA alkylator.
SGTC_1318 1280-3875 124 µM 1.28597197863343 0.0973334788923721 no 394 0.0992264206268027 582 373245
SGTC_1408 3909-7976 48.8 µM 1.28582535985841 0.0973589972351209 no 395 0.0992520087837331 620 24152374
SGTC_620 0109-0052 432 µM 1.28513540578372 0.0974791465517563 no 396 0.0993724855121833 563 493037
SGTC_422 cantharidin 155 µM 1.28344352119526 0.0977742333296196 no 397 0.0996683673443439 570 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1669 st015249 58.4 µM 1.28018271542641 0.0983448067640291 no 398 0.100240441673337 539 722793
SGTC_1277 0873-0036 22 µM 1.27947912340938 0.0984682399879949 no 399 0.100364193301187 615 5965735
SGTC_2789 5281112 71.43 µM 1.27694397071556 0.0989139299811397 no 400 0.100811014452428 556 765948
SGTC_1022 4477-0945 21.3 µM 1.27379364830398 0.0994698235530746 no 401 0.101368278402218 571 4648966
SGTC_175 3793-3120 23.7 µM 1.27228478544231 0.0997368788903405 no 402 0.101635976187185 518 5322297
SGTC_3106 9121286 49.47 µM 1.27080277257354 0.0999996915578935 no 403 0.101899411072128 504 15943471
SGTC_2928 9011484 9.79 µM 1.26839600856911 0.100427571806868 no 404 0.102328283153422 519 2994751
SGTC_180 1486-1293 102.781 µM 1.26800964313825 0.100496385034226 no 405 0.102397253448137 567 4140536
SGTC_2560 caryophyllene 100 µM 1.26774934146336 0.100542765194645 no 406 0.102443739091099 614 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1436 4092-1007 8.32 µM 1.2636126202242 0.101281937071471 no 407 0.103184550812023 543 2881121
SGTC_2903 5923464 63.88 µM 1.26027142270439 0.101881844785466 no 408 0.103785732663467 542 2876576
SGTC_127 0180-0333 59.125 µM 1.25764816774227 0.102354656078997 no 409 0.104259512592509 673 771601
SGTC_2732 terfenadine 20 µM 1.25620723745502 0.102615045050603 no 410 0.104520421702469 510 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.25475608473247 0.102877767624679 no 411 0.104783659531736 550 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1101 ebselen 5.29 µM 1.2547053200584 0.102886967106264 no 412 0.104792876882121 606 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_350 k064-0020 19.8 µM 1.25033632402361 0.103680949320287 no 413 0.105588357303485 624 2790705
SGTC_3183 9108214 49.47 µM 1.2466745558151 0.104349823024612 no 414 0.106258426033361 435 4974831
SGTC_351 caspofungin 25 nM 1.24613646330981 0.104448376154662 no 415 0.106357150086343 722 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2937 9044753 11.33 µM 1.24502078650148 0.104652930290363 no 416 0.10656205477604 615 6465530 YGL099W LSG1
SGTC_1745 st081495 74 µM 1.24421142686578 0.104801504093289 no 417 0.106710879641803 645 13842402 YBL026W LSM2
SGTC_1525 8-methoxypsoralen 92.5 µM 1.24065398574971 0.105456353144183 no 418 0.107366799763864 655 4114 Related to psoralen; DNA damaging agent.
SGTC_1387 3342-1166 1.8 µM 1.23850011808199 0.10585426984286 no 419 0.107765339161002 508 3418228
SGTC_272 doxorubicin 8.13 µM 1.23334367802498 0.106811303681334 no 420 0.10872378426795 658 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2044 5102272 200 µM 1.23328081091843 0.106823010196673 no 421 0.108735507294622 541 592666
SGTC_247 mechlorethamine 29.705 µM 1.23212775195937 0.107037886107567 no 422 0.108950683064222 537 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_130 0136-0219 337.655 µM 1.23117149335145 0.10721632403821 no 423 0.109129365383567 620 234244
SGTC_1367 1812-0510 76.9 µM 1.22962683541734 0.107505010212831 no 424 0.109418438088019 587 1142582 YDR527W RBA50
SGTC_2990 9074105 71.4286 µM 1.22811537202811 0.107788034400082 no 425 0.109701830630661 548 6502001
SGTC_445 e6 berbamine 66 µM 1.2237566208976 0.108607222897098 no 426 0.110522026509657 723 6610268 A calcium/calmodulin antagonist.
SGTC_731 3966-0296 387 µM 1.2221011369491 0.108919526831851 no 427 0.11083469161383 602 660956
SGTC_2884 9058502 51.95 µM 1.22180445784688 0.108975562933322 no 428 0.110890791189004 610 6471554
SGTC_1412 3909-8563 178 µM 1.22150507059655 0.109032131548169 no 429 0.110947423470901 665 23767530
SGTC_2068 5226020 147 µM 1.22096053580701 0.109135074391834 no 430 0.111050481119421 642 1810509
SGTC_564 3555-0129 330 µM 1.21679552415228 0.109924769433591 no 431 0.111841011702918 503 563260
SGTC_1435 4092-0789 56.7 µM 1.21093233114176 0.111043379968329 no 432 0.112960670132369 615 2248285
SGTC_2603 homopterocarpin 100 µM 1.20862225042335 0.111486340501496 no 433 0.113404002063271 633 101795 A weak amylase inhibitor.
SGTC_464 bw-b 70c 158 µM 1.20643696821385 0.11190653333835 no 434 0.113824524542416 674 5353454
SGTC_2498 4'-Methoxychalcone 54.63 µM 1.2061645166597 0.111959000462147 no 435 0.11387703128245 579 641818 YHR062C RPP1
SGTC_1950 st077106 7.18 µM 1.20548499267297 0.11208993584528 no 436 0.114008064038689 632 13831864
SGTC_2477 5967686 25.23 µM 1.20326770614466 0.112517939198571 no 437 0.114436370857999 609 776118
SGTC_2192 5915882 198.485 µM 1.19477259394933 0.114168554270427 no 438 0.116087945373833 566 2876149
SGTC_1393 3470-5649 58.2 µM 1.19361700823871 0.11439441230998 no 439 0.116313908873923 513 4108395
SGTC_3193 9111931 49.47 µM 1.18957472205906 0.115186975053081 no 440 0.117106793005325 630 17087244
SGTC_2768 sulfasalazine 50.2 µM 1.18810761981367 0.115475590092723 no 441 0.117395506350786 628 5384001 An antioxidant and salicylic acid derivative.
SGTC_1300 1094-0077 113 µM 1.18708152747025 0.11567775279407 no 442 0.11759773198481 590 5532636
SGTC_2841 9004761 38.96 µM 1.18650622874209 0.115791209192292 no 443 0.117711221567586 548 2991039
SGTC_1195 1502-0147 41.1 µM 1.18612271327658 0.11586688732206 no 444 0.117786920980463 654 817940
SGTC_2944 9067346 25.62 µM 1.18554364402364 0.115981220121176 no 445 0.117901284642268 611 6473075
SGTC_2067 5224629 34.075 µM 1.18393569275188 0.116299117731716 no 446 0.118219259913075 622 2835000
SGTC_3154 9100113 49.47 µM 1.18267396005495 0.116548999249855 no 447 0.118469194079486 630 25237525
SGTC_1429 4049-0205 9.46 µM 1.1821570569522 0.116651479880769 no 448 0.11857169417072 678 22774478
SGTC_2701 st077767 14.721 µM 1.17506149085687 0.118064700843145 no 449 0.119985057873514 689 5721188
SGTC_1907 st060210 83.7 µM 1.17480654844822 0.118115702011092 no 450 0.120036059838635 710 688793
SGTC_382 3229-0966 23.2 µM 1.17373852432524 0.118329529339204 no 451 0.120249887227673 684 5722370
SGTC_2422 chlorphenesin carbamate 384.24 µM 1.17357494005395 0.118362304425808 no 452 0.12028266185579 670 2724 A muscle relaxant with antifungal properties.
SGTC_3066 9117245 49.47 µM 1.17349448001802 0.11837842742927 no 453 0.12029878458812 665 17176980
SGTC_2775 cyproheptadine 69.59 µM 1.1731030147332 0.118456893445518 no 454 0.120377248855863 652 2913 A selective serotonin reuptake inhibitor.
SGTC_3330 9141424 71.43 µM 1.17260016244066 0.118557740006251 no 455 0.120478092124944 681 27261020
SGTC_1827 berberine 7.24 µM 1.17212152563933 0.118653786517272 no 456 0.120574134409852 592 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1162 k048-0130 20.1 µM 1.17146716717323 0.11878518346838 no 457 0.120705523857131 642 6797406
SGTC_2093 5331342 194.4 µM 1.16944670819503 0.119191545644086 no 458 0.121111850262109 658 33839
SGTC_1479 0549-0158 134 µM 1.16670367893661 0.119744802792751 no 459 0.121665028305922 715 5440202
SGTC_528 3492-0019 172 µM 1.16572409750407 0.119942818285434 no 460 0.121863007003205 846 2869262
SGTC_926 2268-1401 59.4 µM 1.16517184560329 0.120054553812955 no 461 0.121974719800541 652 2931578
SGTC_1021 4476-0760 85.3 µM 1.16466544953759 0.12015707592036 no 462 0.122077219805252 636 746768
SGTC_3305 9127027 53.8275 µM 1.16460161363578 0.120170004156319 no 463 0.122090145169371 647 41905295
SGTC_973 1325-0077 65.9 µM 1.16290925695777 0.120513102731396 no 464 0.122433160613596 710 2835149
SGTC_1708 st033234 31.827 µM 1.16155486339956 0.12078818112912 no 465 0.122708162755772 691 674664
SGTC_2288 7946289 167.31 µM 1.15994950543178 0.121114802582527 no 466 0.123034682601744 712 1246052
SGTC_1940 st075990 51.1 µM 1.15433006285164 0.122263009830563 no 467 0.124182437930287 722 1084979
SGTC_2063 5246145 200 µM 1.15145408269339 0.122853598973814 no 468 0.124772737606801 683 711240
SGTC_2639 lactacystin 53 µM 1.15117094797449 0.122911849323826 no 469 0.124830957321434 689 3870 A proteasome inhibitor.
SGTC_282 k297-0036 65.7 µM 1.14958564474898 0.123238357370311 no 470 0.125157286742679 614 5061378
SGTC_2466 5983409 37.09 µM 1.14785031510824 0.123596461017337 no 471 0.125515181037586 635 2879657
SGTC_360 0957-0399 1.01 µM 1.14517682697637 0.124149588633818 no 472 0.126067957775652 696 6752301 YPR165W RHO1
SGTC_454 lyso-paf C-16 6.67 µM 1.14478201526111 0.124231419182272 no 473 0.126149733588421 627 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1785 bathophenanthroline 24 µM 1.14135655568513 0.124942980032823 no 474 0.126860787922031 653 72812 An iron chelator.
SGTC_1683 st010134 710 nM 1.13831621549482 0.125576921988306 no 475 0.127494232671946 668 3818134
SGTC_22 0964-0034 14.468 µM 1.13783839592321 0.125676755973169 no 476 0.127593984430847 702 138402
SGTC_2371 9071574 200 µM 1.13480043744199 0.126312791821944 no 477 0.128229471464472 614 45596039
SGTC_1574 spiramycin 23.7 µM 1.13418789675428 0.126441306388498 no 478 0.128357869916176 672 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2091 4-phenylthiadiazole 200 µM 1.13185203292039 0.126932220017049 no 479 0.128848323901536 689 270010
SGTC_3304 9125678 46.087 µM 1.12871880097596 0.127592792471182 no 480 0.129508237780013 684 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1164 k060-0068 93.7 µM 1.12728289689783 0.127896318251954 no 481 0.129811445611236 734 5963676
SGTC_2459 5811157 9.22 µM 1.12665413887211 0.12802938486224 no 482 0.129944369797419 659 2870684 YBR192W RIM2
SGTC_1720 st037298 9.481 µM 1.12634792632587 0.128094224678289 no 483 0.130009139545 640 597396
SGTC_572 0960-0087 17.7 µM 1.11960406412821 0.129528007389628 no 484 0.131441261466697 728 6796365
SGTC_2462 5162487 171.77 µM 1.11876126723794 0.129707969227303 no 485 0.131620999882226 711 2259986
SGTC_3167 9103034 49.47 µM 1.11790005519851 0.129892042044184 no 486 0.131804840741085 635 5127859
SGTC_3234 9132280 49.47 µM 1.11688577300428 0.130109063435136 no 487 0.13202158420466 701 17612295
SGTC_2176 5809774 33.9695 µM 1.11635827288112 0.130222029393822 no 488 0.132134403591951 730 2870539
SGTC_906 1165-0455 526 µM 1.11513073837988 0.130485172772537 no 489 0.132397200506913 673 3252859
SGTC_189 3970-0742 2.116 µM 1.11365285680086 0.130802469997756 no 490 0.132714070611564 679 2891807
SGTC_4 0960-0234 25.671 µM 1.11038273233679 0.131506451346162 no 491 0.133417067953 645 6821112
SGTC_2210 7115885 190.385 µM 1.10704984642033 0.132226630476255 no 492 0.134136188869669 720 2927039
SGTC_3121 9125696 49.47 µM 1.10662606748047 0.132318396251995 no 493 0.134227816080406 685 1235365
SGTC_631 k072-0230 41.5 µM 1.10455104690858 0.132768358178461 no 494 0.134677086431398 744 5773147
SGTC_1488 4013-0813 75.9 µM 1.10427135102103 0.132829089883403 no 495 0.134737723252428 659 2910057
SGTC_1670 st016595 4.04 µM 1.10296496299405 0.133113005485292 no 496 0.135021190430021 707 597879
SGTC_2327 6189656 200 µM 1.10254883094823 0.133203530566009 no 497 0.135111570855277 694 5349088
SGTC_2197 6588183 93.1375 µM 1.10245979823665 0.133222904181453 no 498 0.135130913407223 662 884136
SGTC_1700 st030840 7.9285 µM 1.10075784757923 0.133593623332308 no 499 0.135501031013891 744 5499307
SGTC_2350 9023895 38.85 µM 1.09842284574955 0.134103387064969 no 500 0.13600994550205 693 2997209
SGTC_2129 girgensonine 121.053 µM 1.09689642124668 0.134437348411746 no 501 0.136343336678451 760 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3006 9075424 71.4286 µM 1.09687744131318 0.134441504559342 no 502 0.136347485661626 668 7465181
SGTC_1809 st050081 57.6 µM 1.09528387314431 0.134790772216143 no 503 0.136696145229807 709 5036894
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.09244478147974 0.13541456691454 no 504 0.137318824389147 799 65057 A dermal irritant. YDR527W RBA50
SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.0916379461171 0.135592202237975 no 505 0.137496135155958 715 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1020 4335-0961 93.3 µM 1.08933714994404 0.136099628955198 no 506 0.138002618007598 672 669075
SGTC_937 3122-0005 46.7 µM 1.08602329534193 0.136832761254924 no 507 0.138734342993009 762 759535
SGTC_3356 9151811 4.48 µM 1.08491926113849 0.137077607863672 no 508 0.13897870817053 705 1859254 YPR165W RHO1
SGTC_547 1120-0019 610 nM 1.08431294452553 0.137212200674389 no 509 0.139113033909438 719 3676939
SGTC_1169 aniline yellow 25.8 µM 1.08107208701931 0.13793315090556 no 510 0.139832524347465 687 6051 A DNA damaging agent.
SGTC_443 clozapine 122 µM 1.08004997349761 0.138161061857618 no 511 0.140059963614943 631 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.07692528722279 0.138859396366217 no 512 0.140756822488863 741 688667
SGTC_502 l-744,832 89.3 µM 1.07529822632584 0.139223977407404 no 513 0.141120615029986 733 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1489 4065-0444 182 µM 1.07435046269816 0.139436645977321 no 514 0.141332817935857 715 2877968
SGTC_1080 nisoldipine 24.4 µM 1.07384233451832 0.13955075574983 no 515 0.1414466761194 744 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_52 0329-0193 875 nM 1.07085980712317 0.140221818806104 no 516 0.142116235230101 708 3739292
SGTC_1399 3562-5772 25 µM 1.06943978728469 0.140542089571816 no 517 0.142435773582694 643 23847490
SGTC_575 k072-0246 11.9 µM 1.06899958502079 0.140641473380952 no 518 0.142534928198862 761 6796779
SGTC_1244 0416-0015 52.5 µM 1.06613916252415 0.14128842855439 no 519 0.143180369292722 721 96201
SGTC_812 4251-0442 148 µM 1.06267183077096 0.142075352164309 no 520 0.143965399841521 726 5723007
SGTC_3282 9108498 15.4605 µM 1.06070134100233 0.142523881603013 no 521 0.14441282518268 710 16459645
SGTC_632 0781-2353 4.65 µM 1.06018131421254 0.14264241137282 no 522 0.144531060149952 766 6811515 YHR007C ERG11
SGTC_2070 5230947 200 µM 1.0581540085248 0.143105131690159 no 523 0.144992617522266 779 2835538
SGTC_2378 9074213 121.43 µM 1.05739095089482 0.143279557378078 no 524 0.145166599848288 757 657714
SGTC_1833 st055984 71 µM 1.05717105924742 0.143329848570901 no 525 0.145216762703582 743 676288
SGTC_2086 5274770 176.623 µM 1.05652328299734 0.143478070086493 no 526 0.145364604659965 733 689278
SGTC_3017 9080681 49.47 µM 1.05628774203552 0.143531991252118 no 527 0.14541838726011 728 16451914
SGTC_1904 st060225 78 µM 1.05502317714142 0.143821715347441 no 528 0.145707362391687 744 66595
SGTC_3152 9099253 49.47 µM 1.05304951082017 0.144274689418217 no 529 0.146159150528665 836 25236131
SGTC_1457 k015-0032 57.3 µM 1.05283731820769 0.144323446712044 no 530 0.14620777908618 750 4302660
SGTC_1987 st072290 61.9 µM 1.04815149694859 0.145402978320496 no 531 0.147284406625916 771 54697379
SGTC_1118 chelidonine 707.474 nM 1.04752552025059 0.145547602644779 no 532 0.147428634115976 823 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2659 sanguinarine 24.21 µM 1.04663724895056 0.145752992927556 no 533 0.147633457685345 732 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1062 mesoridazine 14.2 µM 1.0438071634019 0.146408677370204 no 534 0.148287308351984 765 4078 A neuroleptic.
SGTC_1467 k284-1082 293 µM 1.04343987557223 0.146493916892456 no 535 0.148372306737279 801 3334705
SGTC_1483 3453-0561 55.9 µM 1.04163830083036 0.146912505602917 no 536 0.148789702157049 789 4546991
SGTC_1648 st011736 69.8 µM 1.04034836595706 0.147212709191067 no 537 0.149089040621942 742 2855514
SGTC_439 amiodarone 34.4 µM 1.04011425498773 0.147267237357463 no 538 0.149143410816426 775 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_429 1112-0049 25.5 µM 1.03937285740828 0.147440009951003 no 539 0.149315681186762 717 2836170
SGTC_500 h-89 112 µM 1.03637168142288 0.148140780282481 no 540 0.150014388238332 821 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2286 7945697 125 µM 1.03603320212334 0.148219954344173 no 541 0.15009332654775 737 1245733
SGTC_3210 9128157 49.47 µM 1.0352019074111 0.148414523523446 no 542 0.150287314099097 688 17590849
SGTC_1680 diphenhydramine 100 µM 1.03264705244741 0.149013570443169 no 543 0.150884550075596 751 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1037 k284-1091 78.7 µM 1.03082398697841 0.149442017991876 no 544 0.151311683772284 721 3334711
SGTC_3174 9107204 49.47 µM 1.02948147204636 0.149758054213378 no 545 0.151626740936867 741 3938802
SGTC_72 0744-0168 198.391 µM 1.02836341083987 0.150021592679692 no 546 0.151889456561817 746 677577
SGTC_723 4182-0001 115 µM 1.0279494238345 0.15011925204928 no 547 0.151986809532153 729 744821 YLR208W SEC13
SGTC_234 nsc-17383 10.7 µM 1.02723783671596 0.150287214173368 no 548 0.15215424281943 825 408974
SGTC_1252 0493-0875 34.8 µM 1.025020971864 0.150811282701298 no 549 0.152676646147329 742 3960963
SGTC_2148 5546263 113.568 µM 1.02301547851089 0.15128642978061 no 550 0.153150263717973 768 792097
SGTC_368 fentichlor 4.58 µM 1.02273832668319 0.151352171588899 no 551 0.1532157924274 685 7329 A pesticide.
SGTC_3153 9100258 49.47 µM 1.0225426880468 0.151398589495481 no 552 0.153262059657109 700 25236848
SGTC_1540 guanosine 70.6 µM 1.02156622361675 0.151630410386619 no 553 0.153493125368952 741 6802 Guanosine is a purine nucleoside
SGTC_2208 7283366 200 µM 1.01857487723251 0.152342049066942 no 554 0.154202418141609 802 898663
SGTC_2184 6075246 200 µM 1.01853965425779 0.152350441766245 no 555 0.154210782926138 785 2267320
SGTC_3289 9119912 71.43 µM 1.01774564609507 0.152539714257742 no 556 0.154399424349359 771 17014829
SGTC_313 3474-0040 5.03 µM 1.01757789273616 0.15257972258833 no 557 0.154439298909391 791 1043375 YIL048W NEO1
SGTC_2676 harmalol 100 µM 1.01441052534737 0.153336430412782 no 558 0.15519345201783 822 5459187 A monoamine oxidase inhibitor
SGTC_2352 9027995 87.8 µM 1.01347940813046 0.153559353374915 no 559 0.15541561348424 737 2997347
SGTC_118 0083-0097 135.343 µM 1.01165470790464 0.153996835170734 no 560 0.155851589154447 984 5207356
SGTC_1523 st012844 44.7 µM 1.01010205669274 0.154369740516637 no 561 0.156223198488484 792 4274103
SGTC_2473 5854593 8.94 µM 1.00487086097648 0.155630525041016 no 562 0.157479518573007 768 2872951
SGTC_333 3486-0131 40.1 µM 1.00163285476183 0.156414319166651 no 563 0.158260473454508 837 6744690
SGTC_192 3455-0609 60.9 µM 1.00131595011231 0.156491168754634 no 564 0.15833704204263 790 3769639
SGTC_920 mycophenolic acid 780.421 nM 1.00087552802868 0.156598012681469 no 565 0.158443494521256 770 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2105 5350118 200 µM 1.00025680940994 0.156748191448788 no 566 0.158593121551585 814 2133313
SGTC_305 1682-2595 20.8 µM 0.999206195237148 0.157003419323359 no 567 0.158847407681066 825 226033
SGTC_1437 4092-1038 11.6 µM 0.998369431880792 0.157206891434247 no 568 0.159050125350618 848 3977136
SGTC_625 k213-0058 121 µM 0.997524790363185 0.157412455011859 no 569 0.159254923436368 963 3655420
SGTC_3090 9117696 49.47 µM 0.996894591301181 0.157565943956974 no 570 0.159407838652348 801 7923821
SGTC_2241 6772625 37.8075 µM 0.996790858181744 0.157591218233339 no 571 0.159433018278954 752 2285411
SGTC_1397 3532-0190 20.1 µM 0.995265619932602 0.157963145656277 no 572 0.159803547105188 738 5322280
SGTC_3095 9117207 49.47 µM 0.994595602600253 0.158126710582481 no 573 0.159966493549973 757 17015229
SGTC_354 2783-3500 4.88 µM 0.993472569505489 0.158401115143097 no 574 0.160239855846345 787 6740761
SGTC_2212 7123476 200 µM 0.992510269346992 0.158636494207145 no 575 0.160474336223248 724 1085715
SGTC_283 0987-0079 11.7 µM 0.990091188589204 0.159229214889052 no 576 0.161064774905453 854 411556
SGTC_232 clozapine 119 µM 0.987603027372516 0.15984037280454 no 577 0.161673551529509 810 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1994 st072947 40.9 µM 0.987355055347833 0.159901365237527 no 578 0.161734304742786 817 5286565 YDL195W SEC31
SGTC_2750 bromebric acid 70.15 µM 0.986581137752254 0.160091819740981 no 579 0.161924010430014 857 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1224 0823-0416 294 µM 0.984097730377829 0.160703966220717 no 580 0.162533731381926 829 3598164
SGTC_2108 5365811 200 µM 0.983217568304645 0.160921287802462 no 581 0.162750185012016 850 780283
SGTC_511 blebbistatin 171 µM 0.983002097339842 0.16097451914208 no 582 0.162803203207275 814 3476986 A myosin inhibitor.
SGTC_1243 0416-0003 5.65 µM 0.982384389933419 0.161127185264703 no 583 0.162955256847325 780 2141977
SGTC_1835 st008666 49.2 µM 0.98086598396618 0.161502860052309 no 584 0.163329416961015 707 690455
SGTC_2375 9072683 200 µM 0.979373991510111 0.161872555600298 no 585 0.163697611557226 918 16798029
SGTC_140 0062-0056 502.533 µM 0.978936510121061 0.161981062027733 no 586 0.163805675501599 893 3758964
SGTC_622 1348-1566 26.3 µM 0.977046714592165 0.162450323257504 no 587 0.164273012947906 876 7340407
SGTC_3035 9091303 49.47 µM 0.975935329780379 0.16272670753874 no 588 0.164548256459104 836 25237002
SGTC_2215 7188065 200 µM 0.975612931780395 0.162806940151177 no 589 0.164628156846121 801 940217
SGTC_1103 duloxetine 36.1 µM 0.974840296830906 0.162999324318313 no 590 0.164819742440417 907 60835 A selective serotonin reuptake inhibitor.
SGTC_2445 5742597 35.57 µM 0.973427751820287 0.163351426396569 no 591 0.165170375843609 786 1774255
SGTC_2205 7238770 200 µM 0.972273359014102 0.163639546049941 no 592 0.165457286865095 838 279867
SGTC_1149 3909-7961 23.3 µM 0.969035907795064 0.164449325789257 no 593 0.166263636848851 819 735261
SGTC_3058 9093861 49.47 µM 0.966012615126987 0.165207879699705 no 594 0.167018934301049 808 17217477
SGTC_2435 5706476 10.6 µM 0.965880072626771 0.165241186777513 no 595 0.167052097428755 882 5725375
SGTC_3033 9090887 49.47 µM 0.964921521127554 0.165482193954079 no 596 0.167292060587156 857 19325384
SGTC_1293 1000-1278 195 µM 0.961956755125569 0.166229059121369 no 597 0.168035663625858 863 678847
SGTC_2131 toluylene red 5.2905 µM 0.961179041051407 0.166425335859749 no 598 0.168231076377427 814 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_317 4495-0002 170 µM 0.960284380285607 0.166651312188942 no 599 0.168456054545809 791 15991618
SGTC_1389 3405-0187 19 µM 0.957109620721991 0.167454800529479 no 600 0.169255964083907 770 799890
SGTC_2405 ticlatone 3.52 µM 0.956081299709452 0.16771558883169 no 601 0.169515580882452 855 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1510 1123-0200 71.5 µM 0.953620390835038 0.168340751175968 no 602 0.170137915176127 909 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_353 1988-1175 58.3 µM 0.951416571022887 0.168901873735163 no 603 0.17069647578408 806 2788357
SGTC_97 0535-0701 19.132 µM 0.950957324075054 0.169018955380546 no 604 0.170813020058583 793 2832013 YGL099W LSG1
SGTC_2310 7668677 200 µM 0.950323051239836 0.169180744285236 no 605 0.170974064809652 821 2197143
SGTC_2082 5219693 150 µM 0.948481252257074 0.169651109656289 no 606 0.171442256267845 854 2834649
SGTC_124 0136-0217 7.121 µM 0.946171617474034 0.170242136984853 no 607 0.172030530044054 971 3976905
SGTC_2433 5607874 27.82 µM 0.944193071261717 0.170749487703443 no 608 0.172535497627062 855 2252428
SGTC_517 1365-0151 113 µM 0.943433829570567 0.170944433683809 no 609 0.172729523149613 851 768657
SGTC_2073 5212005 126 µM 0.942712326427743 0.171129821661549 no 610 0.172914033356408 765 691789
SGTC_204 PMA1.184 62.41 µM 0.942596147830816 0.171159685403536 no 611 0.172943755477816 909 2252213 YGL008C PMA1
SGTC_2681 menadione 3.18 µM 0.940529545784174 0.171691462892744 no 612 0.173473000848735 862 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_750 4073-0104 132 µM 0.939244811461483 0.172022581805544 no 613 0.173802533264479 738 22330957
SGTC_1739 st037196 92.5 µM 0.937014560836871 0.17259835919678 no 614 0.17437553401916 922 612214
SGTC_185 k048-0037 25.491 µM 0.936663398021864 0.17268912973649 no 615 0.174465864757579 897 6827589
SGTC_3196 9111891 49.47 µM 0.934425898336258 0.173268205752087 no 616 0.175042121823444 869 18891510
SGTC_624 k048-0052 28 µM 0.932876632582876 0.173669887002702 no 617 0.175441834308541 832 6835531
SGTC_2017 5132927 60.65 µM 0.931021287267627 0.174151705031133 no 618 0.175921276404335 880 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1945 st075991 56.6 µM 0.926987868004023 0.175202078974227 no 619 0.1769664166576 785 1084980
SGTC_3281 9140613 49.47 µM 0.92545487763172 0.175602348414463 no 620 0.177364672267752 807 16013766
SGTC_3098 9119039 49.47 µM 0.92322601399186 0.176185345793094 no 621 0.177944717427888 888 17161528
SGTC_1927 st060202 13.8 µM 0.922005143492416 0.17650520402818 no 622 0.178262946384135 879 688887
SGTC_602 3130-1533 38.1 µM 0.919794438801451 0.177085324865324 no 623 0.178840095018312 944 720941
SGTC_616 4092-0450 108 µM 0.919369510094775 0.177196970157581 no 624 0.178951165766309 912 787165
SGTC_3128 9127691 49.47 µM 0.918351816024366 0.177464538647636 no 625 0.179217353981038 782 41316314
SGTC_2882 9058044 58.44 µM 0.918155133034494 0.177516279230117 no 626 0.179268827114383 873 18076804
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.916957916949493 0.177831431266334 no 627 0.179582346338921 896 4213774
SGTC_748 act1.228 77.9 µM 0.916028553955119 0.178076317510763 no 628 0.179825959347279 905 4421505 YNR035C ARC35
SGTC_967 1306-0166 352 µM 0.915842941378474 0.178125251702823 no 629 0.179874638647833 891 4437607
SGTC_1933 st074711 15.9 µM 0.915768445893243 0.178144893792066 no 630 0.179894178380304 947 17250958
SGTC_607 4491-0986 66.8 µM 0.915610099527344 0.178186649225865 no 631 0.179935716139241 924 698981 YDR232W HEM1
SGTC_1444 4112-3581 28 µM 0.915455593486519 0.178227397923835 no 632 0.179976252301252 921 2877249
SGTC_535 2293-4129 48.2 µM 0.915293271696665 0.178270214236438 no 633 0.180018845177405 960 396118 YIL048W NEO1
SGTC_578 3460-0051 92 µM 0.913562269904221 0.178727211050481 no 634 0.180473449746881 1003 2876744
SGTC_2607 solasodine 47.35 µM 0.913092865343581 0.178851264214757 no 635 0.180596851194393 887 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_3229 9132204 49.47 µM 0.913066102931878 0.17885833855642 no 636 0.180603888340808 900 17682924
SGTC_2544 sphondin 68.51 µM 0.910086884644304 0.179646962208832 no 637 0.181388345355763 867 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1692 fluoroquinolonic acid 71 µM 0.90892035884744 0.179956345572398 no 638 0.181696083193392 886 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1039 k821-0043 94 µM 0.906812742730732 0.180516170588904 no 639 0.182252915084176 932 15992768
SGTC_678 1218-2179 85.9 µM 0.906762106528978 0.180529634001071 no 640 0.182266306267375 894 6820081 YOR116C RPO31
SGTC_1199 1638-0010 4.46 µM 0.905457630198744 0.180876691920304 no 641 0.182611498296051 882 3111136
SGTC_1847 st056231 15 µM 0.904898400600937 0.181025603785897 no 642 0.182759607218122 955 5393180
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.904403823886127 0.181157363845373 no 643 0.182890655644598 886 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2525 harmine 47.85 µM 0.904075427863901 0.181244884925688 no 644 0.182977703417381 870 5280953 A monoamine oxidase inhibitor
SGTC_2718 lomofungin 53.02 µM 0.899882301314345 0.182364725096047 no 645 0.184091444889664 883 5351222 A RNA synthesis inhibitor.
SGTC_2238 6671620 73.2395 µM 0.898809015790905 0.182652056239975 no 646 0.184377198505472 941 729941
SGTC_900 1112-0045 141 µM 0.898075959490011 0.182848466403793 no 647 0.184572527349622 808 56211 YIL048W NEO1
SGTC_289 k017-0060 526 µM 0.898036139066987 0.182859139393124 no 648 0.184583141510643 907 5512909
SGTC_720 r052-1644 49.9 µM 0.897431786708762 0.183021170492188 no 649 0.184744278639124 818 1422863 YOR257W CDC31
SGTC_1899 st063254 59.6 µM 0.895381802691421 0.183571452563412 no 650 0.185291512441247 814 3093813
SGTC_3243 9134147 49.47 µM 0.892773675886375 0.184273046903559 no 651 0.185989193073693 971 24282180
SGTC_340 k038-0059 454 µM 0.892544119980464 0.184334877959562 no 652 0.18605067775817 931 23733424
SGTC_1295 1013-0063 9.78 µM 0.890255952201831 0.184951903093757 no 653 0.186664233482019 959 6826038
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.889474553153185 0.185162908042049 no 654 0.186874046625708 922 229346 A bile salt which induces apoptosis.
SGTC_1901 st060216 58.6 µM 0.888301759925166 0.185479883524844 no 655 0.187189226635186 949 688792
SGTC_3206 9114350 49.47 µM 0.886023383221386 0.186096631423786 no 656 0.187802463462563 850 17087243
SGTC_1433 4060-0023 7.6 µM 0.885540335764274 0.186227553673834 no 657 0.187932637410502 941 3840627
SGTC_2952 9073731 13.78 µM 0.885207967990402 0.186317669756328 no 658 0.188022237819065 969 16457353
SGTC_38 0929-0051 58.268 µM 0.882121878236843 0.187155702066294 no 659 0.188855451099451 983 1379719
SGTC_366 0181-0206 4.31 µM 0.881934528638665 0.187206652076255 no 660 0.18890610675942 966 274874
SGTC_1087 pterostilbene 9.05 µM 0.881693150471299 0.187272307881122 no 661 0.188971383025159 953 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3269 9137823 49.47 µM 0.881054352505032 0.18744613210924 no 662 0.189144201169142 849 17682936
SGTC_1939 st074455 53.6 µM 0.87773289895984 0.188351543896576 no 663 0.190044343205482 951 1644229
SGTC_2370 9071495 200 µM 0.87751957109725 0.188409788069051 no 664 0.190102246703954 874 21791103
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.877319946563231 0.18846430092915 no 665 0.190156440531664 988 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_125 0133-0007 11.75 µM 0.876210326410184 0.188767489893241 no 666 0.190457851878905 1050 26541
SGTC_1854 st056233 32.9 µM 0.876202075285066 0.18876974552893 no 667 0.190460094269177 908 5393174
SGTC_676 falcarinol 140 µM 0.873878789038055 0.189405530213166 no 668 0.191092133510748 986 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2229 7354935 190 µM 0.871412403867406 0.190081915292183 no 669 0.191764507758532 904 318112
SGTC_357 1325-0123 420 µM 0.870793363400018 0.190251914620543 no 670 0.191933494792852 945 1098503
SGTC_728 3030-5151 22.5 µM 0.869911969308433 0.190494121946309 no 671 0.192174256921009 908 3125388
SGTC_1942 st076330 65.2 µM 0.86910470857441 0.190716123439758 no 672 0.192394930764697 987 24208414
SGTC_1153 4055-0057 267 µM 0.868649647877658 0.190841337783947 no 673 0.192519395011298 959 882706
SGTC_1392 3455-1037 33.9 µM 0.867764777017846 0.19108496290063 no 674 0.192761558068689 922 981132
SGTC_1509 1326-1131 80 µM 0.865970404157584 0.191579579808375 no 675 0.193253196023817 925 768313
SGTC_2893 9048488 25.97 µM 0.865304060887958 0.191763456113753 no 676 0.193435961267992 946 6467338
SGTC_225 nsc-122657 1.016 µM 0.865166253895339 0.191801497202708 no 677 0.193473772251514 833 275685
SGTC_929 2805-0021 398 µM 0.862456533635863 0.192550443374777 no 678 0.194218171124218 928 3098024
SGTC_1373 2887-0003 58.5 µM 0.860646150531206 0.193051814273767 no 679 0.194716479859834 914 776948
SGTC_782 0083-0095 30.5 µM 0.860408737031569 0.193117623085235 no 680 0.194781885668401 1007 3591729 An indicator and reagent.
SGTC_3072 9116419 49.47 µM 0.85953830216013 0.193359016658356 no 681 0.195021798863388 927 17170162
SGTC_64 000l-0018 272.079 µM 0.859304851556415 0.193423789704922 no 682 0.195086174113891 993 6811119
SGTC_3097 9117246 49.47 µM 0.859245798599164 0.193440176596098 no 683 0.195102460328923 982 16423892
SGTC_2233 sulbentine 40.3845 µM 0.857303459418549 0.193979637673647 no 684 0.195638598572484 990 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2519 cryptotanshinone 88.04 µM 0.853829945755422 0.194946646573384 no 685 0.19659960979267 970 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1732 st034308 51.822 µM 0.853155833295526 0.195134655191349 no 686 0.196786446190658 911 830119
SGTC_33 0986-0033 35.816 µM 0.850485565196005 0.195880469863175 no 687 0.197527591193574 941 2848082
SGTC_1281 0884-0031 11.8 µM 0.849651795740698 0.196113698314444 no 688 0.197759352967982 974 1548255
SGTC_485 niflumic acid 177 µM 0.844321194146377 0.197608792177438 no 689 0.19924497293623 959 4488 A COX2 inhibitor.
SGTC_794 k038-0031 316 µM 0.843899417907724 0.197727382756428 no 690 0.199362806752313 1010 6624242
SGTC_291 SEC14.278 35.5 µM 0.843315540938994 0.197891622063838 no 691 0.199525996719273 1009 1068044
SGTC_269 exalamide 29 µM 0.843294536341097 0.197897532002409 no 692 0.199531868871023 957 3316 A derivative of salicylamide.
SGTC_3221 9128209 49.47 µM 0.843173747035138 0.197931519839223 no 693 0.199565639359953 950 16460723
SGTC_2139 5578692 56.4705 µM 0.84263540381223 0.198083042358716 no 694 0.199716192139776 956 650991 YMR113W FOL3
SGTC_2854 9024559 71.43 µM 0.841771007665725 0.198326482467797 no 695 0.199958071600163 959 3163529
SGTC_2657 nystatin 74.44 µM 0.84139041015209 0.198433727470927 no 696 0.200064628044904 1010 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_853 0419-0306 21 µM 0.841359286683974 0.198442499008442 no 697 0.200073343237564 905 762713
SGTC_149 3970-0822 46.1 µM 0.840571946626104 0.198664473128374 no 698 0.200293890083157 1079 3114250 YBL034C STU1
SGTC_749 1000-0129 128 µM 0.837671668259856 0.199483436951666 no 699 0.201107564786642 1042 708470
SGTC_2257 7960413 200 µM 0.836953755277945 0.199686470403374 no 700 0.201309281345553 1017 2974689 YIL048W NEO1
SGTC_1055 3448-0672 86 µM 0.836341494223092 0.199859722556341 no 701 0.201481408003614 940 748378
SGTC_2493 resveratrol 26.09 µM 0.835285993731872 0.200158610820272 no 702 0.201778350788918 934 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1751 st044839 27.194 µM 0.835263084784855 0.200165100971614 no 703 0.201784798642017 1004 5291326
SGTC_1327 1436-0082 2.18 µM 0.834614991863668 0.200348759412797 no 704 0.201967259184778 975 15992205
SGTC_3051 9093778 49.47 µM 0.834346659812909 0.200424829748723 no 705 0.202042832825184 962 17217378
SGTC_1612 st002233 45.4 µM 0.833208241115806 0.200747756700763 no 706 0.20236364778333 999 1035021
SGTC_595 3909-8003 73.7 µM 0.832616146309349 0.200915835310762 no 707 0.20253062491538 1008 699517
SGTC_2984 9022109 38.96 µM 0.831755965513402 0.201160166168961 no 708 0.202773351886614 978 6459207
SGTC_2759 disulfiram 3.38 µM 0.831253182079432 0.201303062233434 no 709 0.202915308442176 974 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_558 k064-0027 21.3 µM 0.831179728071912 0.201323943687912 no 710 0.202936052514432 1004 5088526
SGTC_1786 berberine 21.6 µM 0.830879576534369 0.201409284051762 no 711 0.203020831169024 938 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_903 1134-0042 114 µM 0.83053057647205 0.201508540492429 no 712 0.203119433815712 968 701009
SGTC_2106 5357045 167.29 µM 0.828627732922092 0.202050229031788 no 713 0.203657545044848 983 668842
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.828109914300234 0.202197788813105 no 714 0.203804127637126 1055 16623 A steroid.
SGTC_3057 9095946 49.47 µM 0.82722458601158 0.202450224995225 no 715 0.204054889426422 1039 24540043
SGTC_2364 9055074 200 µM 0.82434907797114 0.203271425794336 no 716 0.204870619949099 987 6470630
SGTC_798 1287-0182 476 µM 0.823777982418265 0.203434758189547 no 717 0.205032860099954 1071 1649755
SGTC_1614 st002383 48.6 µM 0.822504305490822 0.203799309621437 no 718 0.205394968635343 1018 1947235
SGTC_3252 9135871 49.47 µM 0.821864955597114 0.203982450858943 no 719 0.205576879997428 1014 17682838
SGTC_982 1491-0518 27.5 µM 0.82069780839885 0.204317031981512 no 720 0.205909209731961 952 3091256
SGTC_2290 7904846 200 µM 0.819115756212209 0.204771073393023 no 721 0.206360186579488 1012 2962154
SGTC_2056 5235370 200 µM 0.818797602635608 0.204862454370833 no 722 0.206450949483455 951 5511916
SGTC_3241 9133421 49.47 µM 0.818744734381477 0.204877641690802 no 723 0.206466034038887 1039 17018221
SGTC_2413 inermin 26.06 µM 0.817589371435922 0.205209706821501 no 724 0.206795849271784 1027 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1957 st077035 62.4 µM 0.815885495019736 0.205700004410727 no 725 0.207282814435517 1055 705593
SGTC_826 1683-5028 118 µM 0.815759148045319 0.205736388950397 no 726 0.207318951184464 991 722377
SGTC_2570 licareol 100 µM 0.814067332923318 0.20622395418698 no 727 0.207803189367905 948 443158
SGTC_2011 4012611 177 µM 0.813565691773041 0.20636865400545 no 728 0.207946899432469 1037 2049887
SGTC_3259 9138485 49.47 µM 0.812181954646019 0.206768108669029 no 729 0.208343616239813 1107 17646153
SGTC_2265 7929201 200 µM 0.81178582731419 0.206882546196017 no 730 0.208457267910395 1070 1265108
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.81034795913554 0.207298247909567 no 731 0.208870109330623 1018 5355888
SGTC_3080 9117754 49.47 µM 0.810044088544642 0.207386163039576 no 732 0.208957418421387 1071 9550191
SGTC_1805 st050013 60.3 µM 0.808519251461532 0.207827658058023 no 733 0.209395864078573 989 4037144
SGTC_1730 st033808 45.1 µM 0.808275254948292 0.207898355279748 no 734 0.209466072083977 1076 1045166
SGTC_971 1315-0384 26.7 µM 0.806454953176793 0.208426229985168 no 735 0.209990285973915 1023 6769120
SGTC_2815 7968870 71.43 µM 0.806156825394713 0.208512760215794 no 736 0.210076214775557 1044 2977326 YHR190W ERG9
SGTC_2956 9076196 2.52 µM 0.805531556273759 0.208694310515935 no 737 0.210256501983997 1036 16423868
SGTC_2729 fluphenazine 10.66 µM 0.802359681768723 0.209616715634285 no 738 0.211172464147848 1037 3372 An atypical antipsychotic.
SGTC_1578 josamycin 24.2 µM 0.8005414598285 0.210146547775406 no 739 0.21169857622024 961 5282165 A P450 substrate.
SGTC_557 1315-0110 16.2 µM 0.800415743790127 0.21018321063883 no 740 0.211734981148983 1083 6833801
SGTC_3010 9080089 71.4286 µM 0.79882737978789 0.21064675246228 no 741 0.212195256060149 1034 17027233
SGTC_1716 st033144 30.6155 µM 0.796996900156246 0.211181695554394 no 742 0.212726415813521 1070 674617
SGTC_1450 4112-4260 37.6 µM 0.796963349717652 0.211191507826092 no 743 0.21273615855694 1054 1633175
SGTC_1893 st059353 36.1 µM 0.796889489289232 0.211213110231496 no 744 0.212757607874243 999 3112488
SGTC_1105 epirubicin 18.1 µM 0.796724577054407 0.211261347780782 no 745 0.212805503499264 1034 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2087 5276107 200 µM 0.79538585673585 0.211653168120507 no 746 0.213194542242541 1055 144405
SGTC_2883 9059145 45.46 µM 0.794178447631799 0.212006920481128 no 747 0.213545776786337 1048 16476510
SGTC_1883 5-benzylidenerhodanine 20 µM 0.79149418177109 0.212794606994886 no 748 0.214327835009102 1061 1273210
SGTC_2620 irigenin 100 µM 0.790223005951988 0.213168223479871 no 749 0.214698771319125 1062 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2988 9073640 71.4286 µM 0.790200369119874 0.213174880229177 no 750 0.214705380254185 1019 9102229
SGTC_2565 isoliquiritigenin 100 µM 0.788688420216751 0.213619769185654 no 751 0.215147068791383 938 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2814 7977482 42.97 µM 0.787720637787514 0.213904821597541 no 752 0.215430065583152 1095 6456762
SGTC_137 0438-0332 85.389 µM 0.786026244444564 0.21440442424978 no 753 0.215926055977874 1129 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2539 epi(13)torulosol 80 µM 0.784617893531392 0.214820201407287 no 754 0.216338817828126 1048 6708597
SGTC_577 r071-0003 38.6 µM 0.783946260538497 0.215018647554138 no 755 0.216535821884881 1144 4568517 YMR134W ERG29
SGTC_379 3970-0972 5.9 µM 0.783088526175871 0.215272235441466 no 756 0.216787564237184 1037 2898042 YBL034C STU1
SGTC_1316 1272-0050 65.9 µM 0.780524235577075 0.216031398407946 no 757 0.217541183965263 1064 7340392
SGTC_2794 7785382 27.27 µM 0.780504116113019 0.216037360937585 no 758 0.217547102849662 1102 2205081
SGTC_1513 0337-0559 19 µM 0.779653280896192 0.216289598546324 no 759 0.21779749255916 992 775073
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.779632009777402 0.216295906740898 no 760 0.217803754501199 1084 165506
SGTC_227 fluconazole 33.516 µM 0.779607808840464 0.216303083936216 no 761 0.217810879070064 1095 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1168 k815-0004 80.5 µM 0.777649373688744 0.216884347706004 no 762 0.218387872686839 1073 642433
SGTC_3023 9089636 49.47 µM 0.77756083178671 0.21691064826979 no 763 0.218413979662049 1171 17249241
SGTC_1749 st037932 54.2 µM 0.77603782727862 0.217363331365731 no 764 0.218863325639521 1000 594497
SGTC_2920 7982904 15.77 µM 0.774520026240415 0.217815010071369 no 765 0.219311665069773 1021 6456808
SGTC_2110 5483698 200 µM 0.774313177036193 0.217876607710469 no 766 0.21937280657744 1073 2848765 YHR062C RPP1
SGTC_3236 9132701 49.47 µM 0.772157277050088 0.218519211054749 no 767 0.2200106409038 1055 24282524
SGTC_2524 avocatin b 10.57 µM 0.77139736373858 0.218745976252809 no 768 0.220235718610096 1036 6710748
SGTC_2308 7584454 197.62 µM 0.771163978352172 0.218815647795964 no 769 0.220304871208601 1098 893577
SGTC_2282 7944268 200 µM 0.771017689300892 0.218859325351277 no 770 0.220348223319536 1071 2970414
SGTC_761 k216-0224 480 µM 0.770753871416498 0.21893810619541 no 771 0.220426416939314 1126 1340404
SGTC_2453 5731132 22.18 µM 0.76819908399548 0.219701855822838 no 772 0.221184458814936 1120 1362040
SGTC_1776 st049249 45.9 µM 0.767962490385022 0.219772662414622 no 773 0.221254734886408 1121 1822314
SGTC_1896 st058441 89 µM 0.765730334161518 0.220441335842818 no 774 0.221918386932347 1007 688759
SGTC_2772 vinpocetine 57.06 µM 0.764850945482886 0.220705088781387 no 775 0.222180153607581 1070 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_3247 9135149 49.47 µM 0.763748970712929 0.221035856455623 no 776 0.222508425868371 1031 8934436 YOR116C RPO31
SGTC_2202 7226349 200 µM 0.761848427253422 0.221606987777027 no 777 0.223075236707979 1077 844334
SGTC_2298 7976326 193.81 µM 0.759389062831617 0.222347300390122 no 778 0.223809927084003 1020 2235818
SGTC_541 4513-1321 94 µM 0.758227752179994 0.222697365430889 no 779 0.224157325002341 1045 747515
SGTC_2638 epoxomicin 18 µM 0.757779558533374 0.222832552720298 no 780 0.224291480838199 1089 9915668 A protesome inhibitor.
SGTC_1159 4092-0538 61.2 µM 0.752485578028451 0.224432893889688 no 781 0.225879549799502 1161 717301
SGTC_1313 1220-0047 237 µM 0.751399146927133 0.224762120835509 no 782 0.226206237990437 1131 3528706
SGTC_2592 piperlongumine 83.33 µM 0.751303631913771 0.224791078344796 no 783 0.226234971972161 1075 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3055 9094636 49.47 µM 0.750821797192912 0.224937189548721 no 784 0.226379954757626 1134 25236176
SGTC_1050 3232-1156 69.3 µM 0.75031825442027 0.225089940992853 no 785 0.226531525496547 1063 700529
SGTC_1514 1189-1591 158 µM 0.746723882949159 0.226182011648248 no 786 0.227615125112339 1127 767698 YMR146C TIF34
SGTC_890 0929-0006 47.2 µM 0.746614303053331 0.226215352048812 no 787 0.227648206076789 1112 1378169
SGTC_1848 st056003 16.4 µM 0.746201357943968 0.226341018246906 no 788 0.227772893976895 1188 146492
SGTC_945 3381-0768 11.3 µM 0.743426963933444 0.227186335052673 no 789 0.228611612269632 1146 1126236 YIL048W NEO1
SGTC_1914 st062367 72.6 µM 0.741870554248205 0.227661328091931 no 790 0.2290828839745 1076 978205
SGTC_60 0986-0278 202 µM 0.741153985018534 0.227880202154059 no 791 0.229300039998278 980 3110598
SGTC_1625 st003711 30.1 µM 0.740379888646803 0.228116780699268 no 792 0.229534759221568 1146 24207034 YER133W GLC7
SGTC_2010 4012422 159 µM 0.7396238237647 0.228347981741312 no 793 0.229764140887073 1100 952393
SGTC_2088 5278280 127.392 µM 0.739252808974836 0.228461484447372 no 794 0.229876749575997 1175 791502
SGTC_2191 5911152 200 µM 0.737438499834873 0.229016983263523 no 795 0.230427865010282 1126 2875902
SGTC_2387 9077560 195.08 µM 0.736555079662582 0.229287739839013 no 796 0.230696480312197 1115 5303272
SGTC_2742 clothiapine 36.27 µM 0.736416339543614 0.229330278146744 no 797 0.23073868192345 1085 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1564 D-Arginine 115 µM 0.736009678523869 0.229454987621722 no 798 0.23086240386359 1119 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_278 4092-0821 23.9 µM 0.735743814674071 0.229536539806298 no 799 0.230943309905684 1132 877900
SGTC_154 3389-1638 511.116 µM 0.73427037914918 0.229988801847328 no 800 0.231391983541184 1087 5238686
SGTC_1134 3477-0009 42.5 µM 0.732539555108258 0.230520704138376 no 801 0.231919654488993 1156 3973534
SGTC_1792 st045773 43.6 µM 0.732529267261583 0.230523867767014 no 802 0.231922792914989 1102 2919270
SGTC_1693 xanthone 101.9 µM 0.731123775901822 0.230956300217286 no 803 0.232351776494759 1154 7020 An insecticide.
SGTC_507 nimesulide 162 µM 0.730368261985384 0.231188938849646 no 804 0.232582556473887 1131 4495 A COX2 inhibitor.
SGTC_1741 st038134 10.228 µM 0.728768285684729 0.231682036577688 no 805 0.233071707153286 1190 1272587
SGTC_1624 st003710 6.25 µM 0.726117385206109 0.232500307715867 no 806 0.233883406049586 1169 24207033
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.723543878075948 0.233296224339145 no 807 0.234672903420193 1207 6708561
SGTC_3204 9114183 49.47 µM 0.72078927912694 0.234149820539944 no 808 0.235519586257919 1168 17027248
SGTC_2226 7298446 200 µM 0.719281747430223 0.234617706261655 no 809 0.23598366990293 1150 3283010
SGTC_435 c-PAF 6.7 µM 0.71735177073119 0.235217458271124 no 810 0.236578535276641 1145 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1663 st014140 55.4 µM 0.716798114191245 0.235389666545382 no 811 0.236749337748677 1246 4207120
SGTC_2954 9074818 52.69 µM 0.716194981340316 0.235577343002553 no 812 0.236935480767571 1136 16648742
SGTC_1231 0242-0792 125 µM 0.716051968038955 0.235621856462948 no 813 0.236979630315754 1173 3707635
SGTC_2845 9003024 42.97 µM 0.714088464826028 0.23623347356106 no 814 0.237586239169855 1193 2990173
SGTC_995 3931-2021 34.6 µM 0.713506477089221 0.236414926387209 no 815 0.237766203276204 1135 730143
SGTC_1106 tegaserod maleate 11.7 µM 0.712845819763441 0.236620999854734 no 816 0.237970584426842 1176 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2120 5538279 151.968 µM 0.712816093265915 0.236630274522152 no 817 0.237979782888887 1162 2058197
SGTC_821 1114-0266 29.2 µM 0.710322519131295 0.237408981284231 no 818 0.238752079166605 1157 3123235
SGTC_3131 9127911 49.47 µM 0.709083089526086 0.23779655986583 no 819 0.239136458132683 1214 45595681
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.708946298981245 0.237839356510036 no 820 0.2391789011087 1266 688664
SGTC_2699 st077704 54.6 µM 0.708350954277755 0.23802566678337 no 821 0.239363670884105 1166 645852
SGTC_2277 7947813 106.88 µM 0.707097358299709 0.238418235080187 no 822 0.23975298876176 1185 1246798
SGTC_777 1315-0167 517 µM 0.706901937343113 0.238479463812817 no 823 0.239813709980148 1143 4221767
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.706767727752461 0.238521518961941 no 824 0.239855416456024 1165 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1864 st057645 30.4 µM 0.706435798439422 0.238625547866351 no 825 0.239958582572705 1211 688666
SGTC_383 2324-0395 7.37 µM 0.705458722421545 0.238931914207936 no 826 0.240262405524413 1182 3146421
SGTC_146 3448-8650 53.125 µM 0.704278180690629 0.239302364843887 no 827 0.240629775841125 1198 2891488 YIL048W NEO1
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.703485999092005 0.239551124985043 no 828 0.240876464515032 1183 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2798 7813637 45.45 µM 0.702705302144338 0.239796416779574 no 829 0.241119711359932 1161 956368
SGTC_2013 4024628 200 µM 0.702490838346018 0.239863824414162 no 830 0.241186556619756 1188 5230760
SGTC_3295 9122362 53.5725 µM 0.701784660984454 0.24008585446568 no 831 0.241406733048279 1185 4730473
SGTC_1734 st037168 69.4 µM 0.699362796915621 0.240848165902663 no 832 0.242162665759972 1141 708907
SGTC_430 0958-0115 16.4 µM 0.697187411678087 0.241534016186349 no 833 0.242842757943955 1132 6833180
SGTC_1970 st070122 35.8 µM 0.696890842670972 0.241627599840766 no 834 0.242935554508848 1229 102928
SGTC_1259 0671-0132 43 µM 0.696872557497953 0.241633370451743 no 835 0.242941276574846 1140 X1259
SGTC_2376 9072922 81.32 µM 0.694778327937502 0.242294782339961 no 836 0.243597115922649 1227 17087968
SGTC_1866 st057638 64 µM 0.693997434442396 0.242541659617099 no 837 0.243841908923639 1180 688802
SGTC_2753 fluvastatin 17.09 µM 0.693511937279692 0.242695216828528 no 838 0.243994168548683 1193 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2694 st077685 81.9 µM 0.691630727207047 0.243290718858264 no 839 0.244584630010211 1188 2838096
SGTC_1623 st003709 20.3 µM 0.690526852329245 0.243640520707708 no 840 0.24493146473829 1203 16192618
SGTC_169 k015-0017 16.025 µM 0.690297678770383 0.243713176494885 no 841 0.245003503658605 1242 1840002
SGTC_2360 9040895 200 µM 0.690182458943514 0.243749709504314 no 842 0.245039726417928 1162 4914414
SGTC_593 1203-0218 61.7 µM 0.6892577509288 0.244043015792664 no 843 0.245330540033152 1240 3666956
SGTC_1232 0279-0259 161 µM 0.688996659867885 0.244125865195629 no 844 0.245412684751658 1232 1560000
SGTC_1304 1165-0502 251 µM 0.687916796031812 0.244468688575368 no 845 0.245752589471496 1214 767425
SGTC_48 0382-0018 55 µM 0.687356214987287 0.244646757945055 no 846 0.245929141092407 1315 762596
SGTC_3318 9139014 38.6185 µM 0.684785280945089 0.245464312776952 no 847 0.246739712416825 1196 16643984
SGTC_2133 5320837 200 µM 0.683380531615252 0.245911641276397 no 848 0.247183209340228 1191 2841355
SGTC_888 0916-0002 6.97 µM 0.682879079611961 0.246071429588857 no 849 0.247341627194925 1255 2802138 YIL048W NEO1
SGTC_471 1-acyl-paf 4 µM 0.682115590210926 0.246314823363777 no 850 0.247582931639131 1172 16759367
SGTC_2821 7996764 71.43 µM 0.681940069295386 0.246370796142902 no 851 0.247638423629824 1288 2987135
SGTC_2297 7971671 152.32 µM 0.676655328040858 0.248059262944809 no 852 0.249312332978437 1238 909016
SGTC_2246 7293507 91.5585 µM 0.676382006423735 0.248146756373687 no 853 0.249399069227848 1253 887656
SGTC_520 3584-0023 682 µM 0.676021879301199 0.248262062380985 no 854 0.249513376937252 1195 1340790
SGTC_506 n9-isopropylolomoucine 153 µM 0.674618700884937 0.248711606390267 no 855 0.24995902427414 1231 6610355
SGTC_2028 5153890 36.43 µM 0.673185336663186 0.249171268392727 no 856 0.250414694344375 1215 2830968 YPR165W RHO1
SGTC_1676 st018489 23.4 µM 0.672576445832768 0.249366668724744 no 857 0.250608395415979 1243 3696235
SGTC_190 3970-0790 3.722 µM 0.672539440724077 0.249378546730655 no 858 0.250620170082859 1204 2832352
SGTC_315 k915-0449 187 µM 0.672336282102804 0.249443762524929 no 859 0.250684818407243 1266 20970215 YNL149C PGA2
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.672064616257947 0.249530983932681 no 860 0.250771280626132 1210 75037 A free radical scavenger.
SGTC_1629 st005085 44.9 µM 0.669110391020559 0.25048051682592 no 861 0.251712530998866 1238 24207091
SGTC_829 1635-0120 117 µM 0.668738599419933 0.25060015179905 no 862 0.251831120144003 1245 285054
SGTC_2416 tofa 880 nM 0.667891302141539 0.250872907881901 no 863 0.252101489936727 1173 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_817 1391-0715 46 µM 0.666806623846438 0.25122230924047 no 864 0.252447830590851 1208 1353946
SGTC_397 arbidol 50 µM 0.664977104224374 0.251812224752103 no 865 0.253032568724163 1282 131410 A RNA synthesis inhibitor.
SGTC_670 4204-0025 119 µM 0.664741894782203 0.25188811937338 no 866 0.253107796366597 1245 719039
SGTC_1616 st002734 56.1 µM 0.663999260692862 0.252127823040204 no 867 0.253345392132666 1220 4026101
SGTC_830 4076-0286 57.8 µM 0.66307892921579 0.252425049838314 no 868 0.253640002380229 1288 6866659
SGTC_271 rotenone 740 µM 0.662942213813463 0.252469218679888 no 869 0.253683782129596 1287 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1158 4092-0494 91.8 µM 0.661778304803805 0.252845409302445 no 870 0.254056656044741 1329 1148199
SGTC_1260 0700-1617 7.75 µM 0.659493392265421 0.253584780288427 no 871 0.254789493927695 1264 2853078
SGTC_3001 9076041 71.4286 µM 0.65875122441342 0.253825181264189 no 872 0.25502776661871 1262 16004211
SGTC_497 capsazepine 133 µM 0.657794096378943 0.254135388095819 no 873 0.255335224211248 1222 2733484 A calcium channel blocker.
SGTC_465 cgp-37157 41 µM 0.656604639002866 0.254521170180895 no 874 0.255717582624949 1188 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1665 st014639 11.4 µM 0.654699391559701 0.255139746421977 no 875 0.256330658539038 1314 981133 YIL048W NEO1
SGTC_759 3486-0358 89.3 µM 0.654325220266528 0.255261320828953 no 876 0.256451150372661 1286 875103
SGTC_1428 4049-0204 61.7 µM 0.65345871018437 0.255542980443931 no 877 0.25673029997365 1306 X1428
SGTC_3273 9137859 49.47 µM 0.653176842426942 0.255634636707937 no 878 0.25682113885677 1325 2377234
SGTC_1078 idebenone 36.1 µM 0.65015398766459 0.256618670918842 no 879 0.257796379535561 1277 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1242 0402-0103 60.1 µM 0.648751596715427 0.257075862197768 no 880 0.25824947409063 1237 432868
SGTC_2488 5268135 45.7 µM 0.648567359759374 0.257135956466372 no 881 0.258309029351781 1286 1270356 YLR208W SEC13
SGTC_2436 5633522 8.09 µM 0.647800034862186 0.257386320455323 no 882 0.258557146425515 1255 5724242
SGTC_2341 7987486 176.74 µM 0.647706808967278 0.257416746976044 no 883 0.258587299736803 1271 1258686
SGTC_3109 9122853 49.47 µM 0.647640940591973 0.257438245836607 no 884 0.258608605533473 1333 1234709
SGTC_590 k048-0076 22.4 µM 0.647247727018895 0.257566606705499 no 885 0.258735813373898 1297 6832814
SGTC_2333 9017922 200 µM 0.645693321936746 0.258074352831141 no 886 0.259238993146108 1315 3163164
SGTC_468 gf-109203x 121 µM 0.644895631056947 0.258335119798289 no 887 0.259497411584238 1205 2396 A protein kinase C inhibitor.
SGTC_638 3970-0837 4.09 µM 0.644831531478265 0.258356080021782 no 888 0.259518182936423 1264 4118451 YLR208W SEC13
SGTC_3147 9097027 49.47 µM 0.644517976388061 0.258458623576053 no 889 0.259619802265735 1305 25236841
SGTC_1041 0206-0046 107 µM 0.643886832022745 0.258665093915945 no 890 0.259824410625717 1288 50494
SGTC_78 0336-0123 156.75 µM 0.643764563821977 0.258705102174511 no 891 0.259864057919796 1198 6765896
SGTC_1727 st034309 9.9045 µM 0.641716728842062 0.259375664801297 no 892 0.260528562653424 1336 870305
SGTC_3150 9097574 49.47 µM 0.640334090911068 0.259828916226449 no 893 0.260977710956457 1273 17217476
SGTC_93 0109-0045 59.227 µM 0.640127659388753 0.259896622914147 no 894 0.261044804138193 1334 88733
SGTC_1031 k035-0009 16 µM 0.639960914324624 0.259951319635732 no 895 0.261099005129901 1300 5180959
SGTC_779 1360-0071 233 µM 0.638708307118572 0.260362397140866 no 896 0.261506353790578 1365 7566
SGTC_2731 amoxapine 43.43 µM 0.638480096840611 0.260437326666171 no 897 0.261580603039625 1323 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_673 1082-0474 110 µM 0.638178748683441 0.260536286962679 no 898 0.261678664605363 1298 3098046
SGTC_905 2-aminofluorene 215 µM 0.634550839142117 0.261729180818454 no 899 0.262860699763863 1308 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1606 st000094 49.2 µM 0.634135003820036 0.261866090525468 no 900 0.262996360246469 1322 1242210
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.632875739950197 0.262280914730938 no 901 0.263407395710546 1271 803109
SGTC_2030 5175110 200 µM 0.631214189392113 0.262828774027751 no 902 0.263950242701465 1338 2831986
SGTC_3002 9075603 71.4286 µM 0.629069365122935 0.263536846373165 no 903 0.264651822693987 1278 20105405
SGTC_1058 3448-5425 97.3 µM 0.629018899784271 0.263553518245209 no 904 0.264668341507496 1232 7279705
SGTC_2362 9071156 126 µM 0.628220993880947 0.263817188204345 no 905 0.264929589627432 1332 653133
SGTC_2313 7726885 200 µM 0.627894206673611 0.263925214647658 no 906 0.265036623195598 1298 726423
SGTC_3112 9123419 49.47 µM 0.624754096141782 0.264964392792822 no 907 0.266066231297572 1334 17015854
SGTC_1289 0976-0073 69.1 µM 0.623979139568511 0.265221173949272 no 908 0.266320642434585 1337 3391136
SGTC_2904 7225135 42.03 µM 0.6210885385071 0.266180085322109 no 909 0.26727068501246 1371 4446116
SGTC_1206 3978-0017 132 µM 0.62082868808878 0.266266372514097 no 910 0.267356172739023 1386 3873677
SGTC_1972 st070201 17.4 µM 0.620414189644401 0.266404042178775 no 911 0.267492566390208 1315 2829099
SGTC_2555 cholic acid 100 µM 0.619985771305915 0.266546372972784 no 912 0.267633577347518 1309 6708657 Influences liver metabolism.
SGTC_2777 climbazole 1.536 µM 0.619330725396414 0.266764069179758 no 913 0.267849253633477 1295 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_3194 9111903 49.47 µM 0.619256994427933 0.266788578357954 no 914 0.267873535308015 1352 17087251
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.618126588382017 0.267164483132506 no 915 0.268245948454706 1325 3256 An antibiotic and ribosome inhibitor.
SGTC_2157 5649910 96.377 µM 0.617593902076422 0.267341715055529 no 916 0.268421532623855 1286 2858091
SGTC_2959 9079155 11 µM 0.613791516574554 0.268608540440224 no 917 0.269676551947761 1318 16189457
SGTC_1837 st055472 66.5 µM 0.611153062642341 0.269489352962822 no 918 0.270549126873907 1368 676091
SGTC_3016 9080866 49.47 µM 0.610335622173542 0.26976253795193 no 919 0.270819752172614 1315 17066299
SGTC_1274 0865-0114 173 µM 0.609936071418111 0.269896116487593 no 920 0.270952078280659 1329 870624
SGTC_667 1498-1044 59 µM 0.609434212110617 0.270063945904019 no 921 0.271118333369828 1356 6739982
SGTC_1111 tnp00062 510.699 nM 0.607917806034198 0.270571372280283 no 922 0.271620994655648 1402 676306
SGTC_2432 5630864 12.22 µM 0.606921899362813 0.270904885795501 no 923 0.271951372027363 1306 5714970
SGTC_3044 9093193 49.47 µM 0.606853837867485 0.270927686008931 no 924 0.271973957720611 1290 25236277
SGTC_705 1124-0212 310 µM 0.606248215802847 0.271130608109476 no 925 0.272174969903751 1366 9554485
SGTC_2379 9035213 200 µM 0.605674640229468 0.271322862442694 no 926 0.272365413589046 1424 646551
SGTC_2155 5570423 76 µM 0.602363879707681 0.272433908178831 no 927 0.273465973952471 1315 797402
SGTC_2804 7954240 19.48 µM 0.600631594324401 0.273016138431534 no 928 0.274042694869215 1349 828705
SGTC_918 glabranin 770.725 nM 0.600464854339507 0.273072213147912 no 929 0.274098238452865 1396 124049 Also referred to as licorice root.
SGTC_2443 5493264 126.67 µM 0.599976396776423 0.273236514449395 no 930 0.274260982980569 1377 5340055
SGTC_301 4119-0100 24.5 µM 0.598792029786938 0.273635100362387 no 931 0.274655788953533 1330 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3061 glucosamine 200 µM 0.598575978575539 0.273707841077178 no 932 0.274727839338574 1283 91431 and experimental redox chemotherapeutic
SGTC_3019 9081971 49.47 µM 0.598494173820774 0.273735385822834 no 933 0.274755122636477 1405 16451803
SGTC_3223 9129970 49.47 µM 0.596804442561025 0.274304647203204 no 934 0.275318975772183 1401 17248386
SGTC_67 0335-0847 266 µM 0.596596598519228 0.274374709092956 no 935 0.275388371389151 1541 4552207 YOR254C SEC63
SGTC_703 3875-0075 71.8 µM 0.596113459370689 0.27453760399251 no 936 0.275549716643293 1398 2850814
SGTC_934 2950-0684 338 µM 0.595809857858133 0.274639990499098 no 937 0.275651128736113 1386 1121253
SGTC_3218 9131285 49.47 µM 0.592622771271273 0.275715938013048 no 938 0.27671681810298 1429 17156417
SGTC_1507 4075-3230 155 µM 0.591361985451249 0.276142145396716 no 939 0.277138952782114 1280 659771
SGTC_612 0302-0167 22.4 µM 0.591360295342018 0.276142716953432 no 940 0.277139518873717 1415 235821
SGTC_2109 5483026 200 µM 0.590312742076779 0.276497087454866 no 941 0.277490499154396 1391 759335
SGTC_725 1497-0963 19 µM 0.58964746909429 0.2767222543632 no 942 0.277713510054284 1403 3549977
SGTC_2953 9074162 66.49 µM 0.587857428944557 0.277328553338888 no 943 0.278313996449229 1379 16451992
SGTC_1775 st081588 35.1725 µM 0.584417384535789 0.278495540743696 no 944 0.279469766686898 1360 1426443 YGL099W LSG1
SGTC_3351 9150312 21.596 µM 0.583030138228648 0.278966820791549 no 945 0.279936505906924 1358 4904905
SGTC_1766 st045414 44.774 µM 0.58295913477103 0.278990952760552 no 946 0.279960405194937 1365 253960
SGTC_1288 0973-0013 65.5 µM 0.581741524326507 0.279404940358036 no 947 0.280370398585028 1408 4315430
SGTC_765 1319-0117 244 µM 0.581473355616603 0.279496157809826 no 948 0.280460735316991 1324 3487746 YGL099W LSG1
SGTC_3065 9113888 49.47 µM 0.581369254552766 0.279531571630326 no 949 0.280495807148755 1436 16648368
SGTC_2186 6124449 200 µM 0.57829956166618 0.280576819165611 no 950 0.281530945153154 1371 3834182 YLR033W RSC58
SGTC_3186 9110464 49.47 µM 0.574840550955705 0.281756893166939 no 951 0.28269956945362 1405 17018021
SGTC_2296 7971656 126.45 µM 0.574037813094136 0.282031096367602 no 952 0.282971106742444 1375 666570
SGTC_1305 1181-0477 144 µM 0.573224466912117 0.282309054215871 no 953 0.283246360088779 1449 6252086
SGTC_2295 7971645 200 µM 0.571821810496946 0.282788715936718 no 954 0.283721349825387 1435 2978226 YKL099C UTP11
SGTC_167 3672-0051 66.205 µM 0.571692773685324 0.282832861880598 no 955 0.283765065467925 1318 3237971
SGTC_2856 9022925 19.48 µM 0.571617596742302 0.28285858286646 no 956 0.283790535720778 1403 4944862
SGTC_1176 0848-0131 83.3 µM 0.571527913096498 0.282889268634709 no 957 0.283820922335034 1434 6769040
SGTC_55 0767-0285 6.563 µM 0.569175195658454 0.283694834770186 no 958 0.284618625982258 1347 3116166
SGTC_3354 9151612 71.43 µM 0.568461020465431 0.283939584237506 no 959 0.284860983197299 1433 27261949
SGTC_1343 1487-0095 224 µM 0.567917369953595 0.284125962218374 no 960 0.285045538391925 1394 4560101 YGL055W OLE1
SGTC_2147 5545932 89.7195 µM 0.566663735524395 0.284555964613632 no 961 0.285471331808784 1381 797404
SGTC_2266 7929956 200 µM 0.56566085899952 0.284900179495407 no 962 0.285812173881274 1376 2967153
SGTC_1394 3474-0001 65.7 µM 0.563910117161869 0.285501557959113 no 963 0.286407652176633 1352 5017666 YIL048W NEO1
SGTC_933 2914-0560 114 µM 0.5629351949763 0.285836704725153 no 964 0.286739506654523 1466 463887
SGTC_2083 5306046 65.942 µM 0.56270890698299 0.285914521973069 no 965 0.286816559048331 1373 539837
SGTC_732 3970-1727 52.7 µM 0.56110306077459 0.286467038956317 no 966 0.287363640859811 1475 1275699
SGTC_1052 3253-3998 198 µM 0.560629539738094 0.286630058087355 no 967 0.287525054828047 1362 5450317
SGTC_3054 9094397 49.47 µM 0.559906173159477 0.286879176472845 no 968 0.287771718938485 1349 2598354
SGTC_872 0588-0139 234 µM 0.559361113174281 0.287066956054985 no 969 0.287957647478086 1388 2047100
SGTC_1547 harmine 94.2 µM 0.557321824325279 0.28777003084764 no 970 0.288653783567719 1411 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1787 fluconazole 80 µM 0.556650883821917 0.288001525164485 no 971 0.288882990451646 1310 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1200 1643-0193 18.4 µM 0.555603088695169 0.288363221206942 no 972 0.2892411097544 1387 5403974
SGTC_1791 st048313 56.1 µM 0.555356907782113 0.28844823325182 no 973 0.289325280644265 1396 1204976
SGTC_789 1309-1135 70.6 µM 0.552272034106171 0.289514512610494 no 974 0.290380993959317 1381 3092424
SGTC_807 1315-0151 48 µM 0.551577941819663 0.289754678833322 no 975 0.290618776315629 1460 4011080
SGTC_1339 1486-1321 22.7 µM 0.550440463286959 0.290148465277426 no 976 0.291008650910929 1401 3469382
SGTC_1851 st056236 18.9 µM 0.549868481482882 0.29034657575173 no 977 0.291204791886806 1442 5393171
SGTC_3130 9127414 49.47 µM 0.549432374796007 0.290497667337451 no 978 0.291354380743103 1405 1494646
SGTC_3227 9130768 49.47 µM 0.547856805864963 0.291043838345058 no 979 0.291895114844479 1439 17720899
SGTC_2594 a-mangostin 100 µM 0.546428870515605 0.291539246153153 no 980 0.292385584607994 1500 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1470 k295-0292 231 µM 0.546352796076319 0.291565650444493 no 981 0.292411725538916 1467 5045612
SGTC_2489 cantharidin 73.42 µM 0.54617561325835 0.291627152252858 no 982 0.292472613851496 1382 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_813 k007-0158 173 µM 0.545467604849671 0.291872968921227 no 983 0.292715977496923 1481 6523916
SGTC_2645 abamectin 100 µM 0.544287955741016 0.292282750901906 no 984 0.293121666894407 1399 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2829 7992743 58.44 µM 0.543873090355651 0.292426928824777 no 985 0.293264403890535 1463 16462845
SGTC_119 0121-0043 24.815 µM 0.543735937243119 0.292474600836247 no 986 0.293311599350611 1446 1092378
SGTC_796 1234-0020 70.7 µM 0.543680797737845 0.292493767377223 no 987 0.293330574278171 1372 46495034
SGTC_2452 5863136 48.41 µM 0.543145713640645 0.292679793397337 no 988 0.293514740071154 1386 2184096
SGTC_840 0245-0196 390 µM 0.541337454339017 0.293308854663473 no 989 0.294137504518173 1495 3827528
SGTC_1097 itavastatin 7.23 µM 0.540946051636723 0.29344509915762 no 990 0.294272383942065 1430 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2130 NSC 7 2.4545 µM 0.540237848751814 0.293691694024092 no 991 0.294516506951905 1471 21448
SGTC_450 aminopyrene 156 nM 0.538575286185647 0.294270971613707 no 992 0.295089972044973 1460 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1225 1216-0074 20.6 µM 0.537061149246291 0.294798992788002 no 993 0.295612687921783 1399 4241466
SGTC_774 k060-0086 136 µM 0.536897616369599 0.294856047323588 no 994 0.295669168796938 1470 5911235
SGTC_487 nimodipine 119 µM 0.536137170276578 0.29512142410736 no 995 0.295931876289738 1392 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2078 5212016 200 µM 0.535059658867807 0.295497637023704 no 996 0.296304302159833 1410 1899708
SGTC_1425 4048-4433 7.33 µM 0.534500430691086 0.295692978340118 no 997 0.296497675782554 1472 23734946
SGTC_2727 riluzole 51.77 µM 0.533221808496676 0.296139830542874 no 998 0.296940023355477 1434 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1897 st060201 15 µM 0.532771269854485 0.296297358337524 no 999 0.297095962004586 1406 611878
SGTC_627 1391-0720 175 µM 0.531871004517211 0.296612245083542 no 1000 0.297407670388912 1413 997839
SGTC_950 1165-0508 94.1 µM 0.531736940759208 0.29665914981387 no 1001 0.297454101476517 1410 6148369
SGTC_2504 purpurogallin 52.29 µM 0.530597870813006 0.29705781185497 no 1002 0.29784873572915 1419 5281571 An antioxidant.
SGTC_492 tmb-8 126 µM 0.530094185229154 0.297234174396643 no 1003 0.298023315231076 1370 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1336 1486-0901 104 µM 0.529613624352169 0.297402484553474 no 1004 0.298189923072355 1472 5006114
SGTC_569 4130-2812 160 µM 0.528740157688482 0.297708516233798 no 1005 0.29849285778658 1417 743552
SGTC_1992 st073643 23.3 µM 0.527066099403502 0.298295447966845 no 1006 0.29907384374827 1446 3161292
SGTC_1409 3909-8004 61.9 µM 0.526464560665692 0.2985064785159 no 1007 0.299282734528929 1443 2119279
SGTC_1615 st002656 86.5 µM 0.526290541548094 0.298567540198969 no 1008 0.299343176875844 1417 1584458
SGTC_518 1021-0119 62.6 µM 0.526072605435332 0.298644019957152 no 1009 0.299418880792656 1400 1097762
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.524377520046318 0.29923917574775 no 1010 0.300007994426857 1397 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2164 5685496 200 µM 0.522926242995141 0.299749155998244 no 1011 0.300512790700496 1452 759046
SGTC_734 2023-0417 80 µM 0.520702600723708 0.300531308782515 no 1012 0.301286981198452 1481 3935732
SGTC_1057 3448-5381 134 µM 0.518860322856166 0.301180016168445 no 1013 0.301929074123328 1543 5497911
SGTC_3306 9127676 59.7925 µM 0.518149444177809 0.301430501070132 no 1014 0.302177002419075 1450 41905287
SGTC_3166 9102297 49.47 µM 0.517195862523172 0.301766651851843 no 1015 0.302509719994797 1390 25237072
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.516972702404199 0.301845343220905 no 1016 0.302587607295867 1453 5106787 A p450 inhibitor.
SGTC_2872 9044037 25.97 µM 0.516347247620502 0.30206594202968 no 1017 0.302805951280203 1511 6465195
SGTC_811 0416-0114 265 µM 0.515082401231348 0.302512276262952 no 1018 0.303247720001473 1457 6612453
SGTC_2096 5468907 200 µM 0.514338832334062 0.302774801970515 no 1019 0.303507558263444 1538 759785
SGTC_2125 5246583 200 µM 0.513510651850914 0.303067320836616 no 1020 0.303797080826197 1564 835267
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.513229765174835 0.303166560586906 no 1021 0.303895303617481 1439 2374 Ca(2+)-ATPase inhibitor.
SGTC_889 0919-1524 82.7 µM 0.513030985389298 0.303236800025653 no 1022 0.303964823144764 1435 3905452
SGTC_147 4466-0538 29.23 µM 0.511166683622467 0.303895910472436 no 1023 0.304617172752253 1500 6742687 YHR072W ERG7
SGTC_367 0335-0881 7.1 µM 0.511044307699166 0.303939197936579 no 1024 0.304660015856234 1533 23828853
SGTC_752 1896-0090 130 µM 0.510988790719505 0.303958836605215 no 1025 0.30467945291372 1464 772567
SGTC_2231 micatex 6.853 µM 0.510121722234771 0.304265628243891 no 1026 0.304983093910771 1491 20737 An antifungal of unknown mechanism.
SGTC_2497 7-hydroxyflavone 100 µM 0.508738539104133 0.304755320063414 no 1027 0.305467752458236 1501 5281894
SGTC_2079 5212404 121 µM 0.507914488927386 0.30504722706926 no 1028 0.305756656600537 1548 758462
SGTC_1076 itraconazole 331 nM 0.506663341235112 0.305490663937149 no 1029 0.306195528232209 1465 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1667 st014849 34.6 µM 0.50638183740579 0.305590475040681 no 1030 0.306294311175229 1498 5348460
SGTC_2357 9067248 200 µM 0.50617515032197 0.305663768024234 no 1031 0.306366849024603 1489 9150235
SGTC_5 0352-0601 109.883 µM 0.505644346904314 0.305852031065394 no 1032 0.306553171863534 1443 762456
SGTC_683 panaxydol 45 µM 0.504732210567581 0.306175663438353 no 1033 0.306873467141325 1482 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1094 duloxetine 25.4 µM 0.504031512685581 0.30642437875062 no 1034 0.307119616311025 1463 60834 A selective serotonin reuptake inhibitor.
SGTC_958 1222-0007 33 µM 0.503698556047932 0.306542594216591 no 1035 0.307236611608463 1553 7312461
SGTC_2182 6325192 200 µM 0.503171211629919 0.306729867795246 no 1036 0.307421951612271 1442 736248
SGTC_3105 9121040 49.47 µM 0.502920325634 0.306818981588835 no 1037 0.307510145051809 1396 41448907
SGTC_35 0133-0054 64.071 µM 0.502885533189229 0.306831340640312 no 1038 0.307522376447305 1382 99677
SGTC_2598 perillyl alcohol 100 µM 0.502187030064269 0.307079510950184 no 1039 0.307767982722625 1530 10819 An apoptosis inducer.
SGTC_2853 9015042 58.44 µM 0.501745907224046 0.307236282488997 no 1040 0.307923133853352 1394 6457456
SGTC_2138 5575593 77.673 µM 0.499708510401821 0.307960813902746 no 1041 0.30864016958394 1454 762213
SGTC_549 1661-1316 519 µM 0.498879124254928 0.308255971837019 no 1042 0.308932270729846 1564 2857282
SGTC_1789 tunicamycin 25 nM 0.497000866042619 0.308924855519519 no 1043 0.309594220303576 1455 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1246 0422-0085 105 µM 0.496964544926448 0.308937796420798 no 1044 0.309607026957155 1532 264295
SGTC_418 lividomycin a 100 µM 0.496933710329734 0.308948782708519 no 1045 0.30961789927138 1492 72394 An antibiotic.
SGTC_3100 9120536 49.47 µM 0.495487198347359 0.309464363160596 no 1046 0.310128128147454 1457 16421196
SGTC_3290 9121031 71.43 µM 0.494943248338525 0.309658340480212 no 1047 0.310320090590908 1456 17014854
SGTC_3185 9108267 49.47 µM 0.49466930918114 0.309756049654287 no 1048 0.310416784543829 1430 4910486
SGTC_832 4083-0019 164 µM 0.494279912965759 0.309894963421236 no 1049 0.310554254619964 1618 1990758
SGTC_1655 st012546 55.1 µM 0.493975027971131 0.310003747483432 no 1050 0.310661907838771 1467 720985 YLR208W SEC13
SGTC_1671 st016596 74.5 µM 0.492899228672599 0.310387729392531 no 1051 0.311041896163673 1487 2829167
SGTC_3274 9138298 49.47 µM 0.492666719572867 0.310470745373189 no 1052 0.311124048336874 1461 17015756
SGTC_2887 9044784 58.44 µM 0.492366088122765 0.310578098342727 no 1053 0.31123028405235 1458 6465546
SGTC_432 NS 1619 61.3 µM 0.492330734562362 0.310590723862996 no 1054 0.311242778159355 1500 4552 A K+/calcium channel activator.
SGTC_2058 5236698 133 µM 0.492211530855764 0.310633295726402 no 1055 0.311284906887304 1507 766665
SGTC_1196 1588-0294 184 µM 0.491799764436309 0.310780371598057 no 1056 0.311430451539618 1460 6144269
SGTC_2033 5192550 145 µM 0.491409935939236 0.310919639488622 no 1057 0.311568269086859 1464 182073
SGTC_2864 9034755 47.6 µM 0.490957158831745 0.311081430038925 no 1058 0.311728374237303 1474 4930451
SGTC_1430 4049-0248 69.1 µM 0.489724207252789 0.311522184858501 no 1059 0.312164534895437 1590 22774488
SGTC_2738 aclarubicin 5.55 µM 0.48935507364945 0.31165419511788 no 1060 0.31229516838074 1517 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1384 3089-0840 101 µM 0.488665349680088 0.311900920381886 no 1061 0.312539319513794 1581 1069836
SGTC_1279 0874-0590 65.2 µM 0.486792594793707 0.312571260277611 no 1062 0.313202659333378 1523 3523074
SGTC_2 0422-0095 29 µM 0.486740305646417 0.312589985737884 no 1063 0.313221189119888 1409 6790840
SGTC_1964 st076914 61 µM 0.486637480428677 0.312626810268696 no 1064 0.313257628827876 1499 24208661
SGTC_739 1486-1183 203 µM 0.48577821693373 0.312934609194755 no 1065 0.31356221012232 1559 4346692
SGTC_1729 st035615 45.989 µM 0.482867625834734 0.313978187582388 no 1066 0.314594865000705 1491 17385451
SGTC_2384 9036245 200 µM 0.482043019930797 0.314274117188195 no 1067 0.314887693015301 1583 6462766
SGTC_1002 4049-0206 172 µM 0.481777328423503 0.314369492404573 no 1068 0.314982068245361 1483 4662749
SGTC_3291 9121177 71.43 µM 0.480542653854067 0.314812865761958 no 1069 0.315420790553421 1487 17015612
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.480281587992922 0.314906649103057 no 1070 0.315513589591915 1542 688801
SGTC_3081 9117243 49.47 µM 0.480118888049448 0.314965102247874 no 1071 0.315571429153524 1605 45595589
SGTC_1382 3002-2117 298 µM 0.479207612620028 0.315292581459399 no 1072 0.315895469557716 1624 1497314
SGTC_1822 st052468 42 µM 0.478431858877843 0.315571473523755 no 1073 0.316171431345224 1473 2873678
SGTC_2336 9001819 198.65 µM 0.478323117061791 0.315610575811721 no 1074 0.316210122668431 1620 2989602
SGTC_1819 st053448 58.6 µM 0.478270790319182 0.315629392633416 no 1075 0.316228741714706 1543 2857616
SGTC_1210 3013-0140 750 nM 0.477701962840982 0.315833975185691 no 1076 0.316431173537984 1641 905973
SGTC_968 1309-0633 340 µM 0.476709252478259 0.316191145160735 no 1077 0.31678458669237 1528 3761976
SGTC_2113 5491891 107.031 µM 0.476060124751286 0.316424789406385 no 1078 0.317015772042569 1486 789979
SGTC_1944 st076371 56.9 µM 0.475937183883528 0.316469048471796 no 1079 0.317059565200638 1467 24208455
SGTC_1808 st050063 61.5 µM 0.475321163216701 0.316690857252817 no 1080 0.317279038462709 1566 4011993
SGTC_3005 9076496 71.4286 µM 0.475207961673531 0.316731624577974 no 1081 0.317319376426785 1542 21368410
SGTC_503 tyrphostin 8 294 µM 0.474659334042742 0.316929233633102 no 1082 0.317514903805733 1586 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_531 3788-1495 174 µM 0.472134287947471 0.317839397502475 no 1083 0.318415469925409 1505 2896655
SGTC_2626 ethyl orsellinate 100 µM 0.471381600406127 0.318110920401877 no 1084 0.318684126491906 1481 75653 A natural product.
SGTC_1440 4100-1550 40 µM 0.471089421211892 0.318216346855889 no 1085 0.318788439628445 1541 742806
SGTC_820 1582-0060 59.9 µM 0.469451640219581 0.318807576663872 no 1086 0.319373422018825 1492 3848840
SGTC_74 000s-0487 160.283 µM 0.467670656422472 0.319451025640666 no 1087 0.320010064201055 1414 677548
SGTC_2982 9019404 25.97 µM 0.464957063007664 0.32043246130034 no 1088 0.320981102526581 1360 22333232
SGTC_1115 galangin 695.678 nM 0.46445707322095 0.320613431863504 no 1089 0.321160153906032 1575 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2098 5376439 882.5 nM 0.46176122622349 0.321589923729566 no 1090 0.322126279562955 1631 2844116
SGTC_1560 lithocholic acid 53.1 µM 0.458985278945496 0.322596719318535 no 1091 0.323122368728572 1553 9903 A bile acid which acts as a detergent.
SGTC_292 k038-0015 474 µM 0.458804128159415 0.32266246540401 no 1092 0.323187415010616 1559 46368540
SGTC_2149 5554786 194.827 µM 0.458364332131254 0.322822106146675 no 1093 0.323345356202334 1552 745063 YPR165W RHO1
SGTC_2262 9014885 67.46 µM 0.458099192438188 0.322918364490847 no 1094 0.323440589545255 1558 6457424
SGTC_2648 atorvastatin 78.68 µM 0.456998975165458 0.323317922485617 no 1095 0.323835891061042 1617 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.456803180964158 0.323389049039327 no 1096 0.323906259600614 1690 1273210
SGTC_1744 st037937 38.9 µM 0.456468830703043 0.323510524053526 no 1097 0.32402643981126 1593 1016152
SGTC_2390 9097792 176.6 µM 0.455956551109693 0.323696680244022 no 1098 0.324210611240629 1487 4497149
SGTC_2419 paclitaxel 166.5 µM 0.45589413323622 0.323719365158457 no 1099 0.324233054249932 1562 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_58 0957-0393 9 µM 0.452414905388533 0.324984876173379 no 1100 0.325485055522446 1519 6997992
SGTC_2049 5262831 67.185 µM 0.451876629580831 0.325180845983707 no 1101 0.325678930720332 1558 763417
SGTC_2225 6654152 15.4 µM 0.450128443190268 0.325817640725711 no 1102 0.326308914393051 1609 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_613 3914-0030 117 µM 0.449476075480781 0.326055402710696 no 1103 0.326544131463296 1503 1145395
SGTC_1925 st057770 10.1 µM 0.449305075340097 0.326117737139484 no 1104 0.326605798522409 1460 5989122
SGTC_3191 9110352 49.47 µM 0.448175108095562 0.326529764495225 no 1105 0.327013412875135 1594 17122424
SGTC_51 1013-0126 23.419 µM 0.447559901273824 0.326754180434346 no 1106 0.327235423959477 1671 1627850
SGTC_867 0518-0118 155 µM 0.447188246827185 0.326889783404685 no 1107 0.327369573371893 1576 6848158
SGTC_1446 4239-0190 62 µM 0.447090591455296 0.326925418034184 no 1108 0.327404825972544 1528 1340085
SGTC_2072 5231554 129 µM 0.446404861069764 0.327175686784025 no 1109 0.327652411035611 1671 789545
SGTC_1491 4138-0063 26.5 µM 0.445886915845567 0.327364771070958 no 1110 0.327839467004851 1577 23883227
SGTC_1142 3253-1408 9.78 µM 0.445567115141959 0.3274815416185 no 1111 0.327954984637017 1581 256655
SGTC_771 0250-0039 27.3 µM 0.445202809095866 0.32761458320724 no 1112 0.328086598437524 1566 3005115
SGTC_1529 apigenin 74 µM 0.445089081593053 0.327656120045423 no 1113 0.328127689443746 1648 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_895 0964-0006 13.7 µM 0.443756983382988 0.32814280262812 no 1114 0.328609146033654 1555 6738897
SGTC_176 1486-1328 72.834 µM 0.44167994803595 0.328902230439939 no 1115 0.329360410952523 1535 22310231
SGTC_972 1319-0219 195 µM 0.440200629230121 0.329443546008127 no 1116 0.329895902025199 1530 23903702
SGTC_395 anisomycin 6.25 µM 0.438019057111025 0.330242484009432 no 1117 0.330686234436665 1552 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1346 1488-2224 62.4 µM 0.436658702919189 0.330741066937155 no 1118 0.331179441521611 1631 3722427
SGTC_642 0335-0876 158 µM 0.435327997213814 0.331229074133535 no 1119 0.331662182866521 1588 6812350
SGTC_1492 4158-0558 28.5 µM 0.433984474197178 0.331722072754409 no 1120 0.332149857741456 1680 3967268
SGTC_1923 st058458 19.1 µM 0.432750461041672 0.33217514426231 no 1121 0.332598033108242 1700 3534982
SGTC_909 3448-9333 149 µM 0.429717559663059 0.333289724531856 no 1122 0.333700554224271 1541 3344074
SGTC_2955 9076254 12.21 µM 0.427616953561399 0.334062554213418 no 1123 0.334465010408069 1670 16459619
SGTC_263 alizarin 107.927 µM 0.426027820172424 0.334647677099979 no 1124 0.335043787151926 1619 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1695 st026914 34.495 µM 0.425994384277654 0.334659992600604 no 1125 0.335055969021596 1561 3289191
SGTC_1013 4112-3890 241 µM 0.4253158390611 0.334909960744699 no 1126 0.335303224328264 1557 705171
SGTC_2571 chrysanthemic acid 100 µM 0.425083116785541 0.334995709770736 no 1127 0.335388042512722 1518 2743 An insecticide.
SGTC_740 k014-0057 261 µM 0.420518516648875 0.336679319899516 no 1128 0.337053352701183 1716 4012779
SGTC_59 0330-0160 1.33 µM 0.419952015337584 0.336888498001902 no 1129 0.337260254030899 1646 4293482
SGTC_1007 4101-0031 70 µM 0.419068149374739 0.337214962360698 no 1130 0.337583163664121 1698 1146276
SGTC_3113 9123498 49.47 µM 0.416320614834755 0.338230572635656 no 1131 0.338587704831463 1631 8897275
SGTC_1415 3966-0071 78.1 µM 0.415572196632864 0.338507425595078 no 1132 0.338861537619223 1616 2893185
SGTC_452 diindolylmethane 8 µM 0.415153997001742 0.338662162971807 no 1133 0.339014586463578 1642 3071 Inhibits expression of several cancer promoting factors.
SGTC_2927 9011802 47.9 µM 0.414338992742149 0.338963799639112 no 1134 0.339312930545008 1523 43912568
SGTC_1081 sertraline 6 µM 0.414117571941494 0.339045766301092 no 1135 0.339394002240814 1700 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1416 3966-0321 25.3 µM 0.413751564919563 0.339181273321201 no 1136 0.339528029481437 1621 582530 YLR208W SEC13
SGTC_419 nsc-638432 893 µM 0.411241445576086 0.340111156240641 no 1137 0.340447750279588 1604 368090
SGTC_403 arphamenine a 50 µM 0.411175009296652 0.340135781050581 no 1138 0.340472105802752 1652 5487158 An arginine aminopeptidase inhibitor.
SGTC_3163 9099914 49.47 µM 0.410383291790418 0.340429286019514 no 1139 0.340762400421491 1671 16268368
SGTC_1011 4112-3381 17.4 µM 0.41000064336464 0.340571175846279 no 1140 0.340902737798002 1649 2877139
SGTC_1771 st048882 4.1505 µM 0.409102199897865 0.3409044162492 no 1141 0.341232330956226 1539 4580403
SGTC_2567 aureobasidin a 60 nM 0.407066080220478 0.341660089781678 no 1142 0.341979727689849 1675 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1852 st056254 31.4 µM 0.406063415770668 0.3420324463436 no 1143 0.342348002773968 1679 442583
SGTC_2878 9043973 25.97 µM 0.405787810808074 0.342134823894612 no 1144 0.342449257786158 1706 6465167
SGTC_1163 k060-0048 49.9 µM 0.403650539305314 0.34292913855334 no 1145 0.343234857818426 1619 6809982
SGTC_1527 coumarin 137 µM 0.403123635843778 0.343125068542934 no 1146 0.343428636798713 1674 323 A hepatotoxic, DNA x-linker.
SGTC_652 0437-0092 114 µM 0.402373119540281 0.343404222190347 no 1147 0.343704724809242 1576 3091274
SGTC_24 0417-1663 219 µM 0.40217673130616 0.343477282671745 no 1148 0.343776982762023 1610 4329390
SGTC_117 lucigenin 22.078 µM 0.4018794380807 0.343587893022422 no 1149 0.343886377973268 1553 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1581 himbacine 57.9 µM 0.401416760180955 0.343760062720285 no 1150 0.344056655904664 1606 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1236 0330-0013 258 µM 0.401320728661656 0.343795801616305 no 1151 0.344092002055373 1615 4617066
SGTC_2084 5306078 60.6385 µM 0.399287421669476 0.344552840271725 no 1152 0.344840717091925 1674 679340
SGTC_1047 2043-3044 82 µM 0.396285659475222 0.345671591326437 no 1153 0.345947152605463 1573 669592
SGTC_2456 5770359 74.46 µM 0.396184054418255 0.345709482997094 no 1154 0.34598462684468 1713 3118787
SGTC_956 1185-0240 191 µM 0.396107033446235 0.345738207531504 no 1155 0.346013034923473 1645 1416193
SGTC_1355 1499-0035 1.68 µM 0.393843969328621 0.346582600215659 no 1156 0.346848119861271 1608 1548538
SGTC_2895 9054447 58.44 µM 0.393724546209794 0.346627180500398 no 1157 0.346892208461583 1644 2697450
SGTC_1005 4092-0690 4.4 µM 0.393347614709536 0.346767901805147 no 1158 0.347031377543768 1602 1529343
SGTC_3256 9138902 49.47 µM 0.393229303025943 0.346812075927128 no 1159 0.347075064347783 1706 17228773
SGTC_2915 7971052 15.16 µM 0.390914317642317 0.347676842109475 no 1160 0.347930285230836 1599 5741558
SGTC_2846 9008642 19.48 µM 0.390646394404803 0.347776976521715 no 1161 0.348029313695755 1622 2992898
SGTC_2656 pseudo-anisatin 100 µM 0.386215785511058 0.349434420360939 no 1162 0.349668431936004 1673 6708809 A neurotoxin.
SGTC_1596 piperlongumine 63 µM 0.382772894581608 0.350724356432061 no 1163 0.350944080340743 1754 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2062 5245942 200 µM 0.381128213116612 0.35134117258977 no 1164 0.351554056738298 1659 1376160
SGTC_2173 5763948 167 µM 0.380305769537785 0.351649766272017 no 1165 0.351859226620408 1661 2867177
SGTC_736 0958-0254 92.6 µM 0.378335154328187 0.35238956939442 no 1166 0.352590816720062 1706 6812352
SGTC_3039 9090270 49.47 µM 0.376515291081521 0.353073274058022 no 1167 0.35326692489622 1789 17173750
SGTC_2474 5321570 43.32 µM 0.373920127378189 0.354049072017188 no 1168 0.354231870700862 1755 2841384
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.372716094944916 0.354502122009574 no 1169 0.354679878110743 1736 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_3263 9137018 49.47 µM 0.37140299290234 0.354996447169741 no 1170 0.355168698363773 1571 43844957
SGTC_2100 5377183 190 µM 0.371291809008115 0.355038314239733 no 1171 0.355210099054109 1776 2844202
SGTC_3294 9122953 26.2835 µM 0.371262991258196 0.355049166049883 no 1172 0.355220829976608 1618 16459826
SGTC_3117 9124945 49.47 µM 0.370997232283972 0.355149247618307 no 1173 0.355319796581648 1583 17592065
SGTC_2840 9008771 71.43 µM 0.370021674352619 0.355516716388212 no 1174 0.35568317048819 1818 2992978
SGTC_136 0097-0015 404.482 µM 0.36846115667415 0.356104804377409 no 1175 0.356264701707499 1738 4861337
SGTC_110 0850-0284 111.64 µM 0.365931712863808 0.357058763437728 no 1176 0.357208015837662 1643 3906265
SGTC_151 3013-0144 2.285 µM 0.365435983014915 0.357245828899082 no 1177 0.357392992605595 1766 906558 YHR107C CDC12
SGTC_3046 9092212 49.47 µM 0.365061069685566 0.357387326599829 no 1178 0.35753291012421 1669 25236637
SGTC_2385 9074692 200 µM 0.364360697392502 0.357651709730382 no 1179 0.357794340101843 1648 17046906
SGTC_378 3970-0959 8.33 µM 0.364201248526142 0.357711909542005 no 1180 0.357853867366432 1715 6615653
SGTC_1025 k007-0731 70 µM 0.362801744329476 0.358240443132637 no 1181 0.358376494375919 1653 6256118
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.362109393008444 0.358502015505161 no 1182 0.358635142345397 1740 5377381
SGTC_416 estradiol valerate 100 µM 0.361831004915605 0.358607210072148 no 1183 0.358739160600034 1700 13791 A steroid.
SGTC_2961 9083290 32.55 µM 0.361128613968396 0.358872670352161 no 1184 0.359001651857471 1690 17741490
SGTC_1356 1502-0781 85.8 µM 0.361062147979204 0.358897793912837 no 1185 0.35902649438255 1692 567702
SGTC_1447 4239-0816 81.9 µM 0.360973507838665 0.35893130005797 no 1186 0.359059625711841 1623 1341554
SGTC_2031 5180455 200 µM 0.358351070381352 0.359923076568341 no 1187 0.360040301807863 1672 29949
SGTC_2472 5377652 49.4 µM 0.357592436522618 0.360210159711184 no 1188 0.360324169659632 1665 1610903
SGTC_1690 st023502 41.2 µM 0.357247172016219 0.360340841240979 no 1189 0.360453387260631 1793 24207482
SGTC_1458 k015-0034 6.33 µM 0.35714816522897 0.360378318009734 no 1190 0.360490444168629 1624 3598957
SGTC_1452 4194-0072 190 µM 0.356348723513615 0.3606809776185 no 1191 0.36078971242376 1837 1343545
SGTC_2678 equilin 100 µM 0.35465375986308 0.361322960242072 no 1192 0.361424498065774 1802 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1294 1000-1494 117 µM 0.354117543484323 0.361526138424632 no 1193 0.361625397535552 1650 712797 YDL207W GLE1
SGTC_1497 4476-2978 41.3 µM 0.352101580743186 0.362290357495112 no 1194 0.362381041474182 1713 1528379
SGTC_2968 9090663 33.37 µM 0.350613058233088 0.362854985097833 no 1195 0.362939329333293 1706 25236811
SGTC_646 4092-0839 27.3 µM 0.350297407875887 0.362974756230383 no 1196 0.363057755199647 1783 877796
SGTC_2807 7945238 51.95 µM 0.349935410078734 0.363112130047292 no 1197 0.363193585842783 1725 17148797
SGTC_2734 clemastine 41.6 µM 0.348035471218089 0.363833422464047 no 1198 0.363906772303419 1742 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1166 k206-0078 225 µM 0.34673421877365 0.364327708419878 no 1199 0.364395500152133 1669 5404595
SGTC_543 3844-1095 191 µM 0.346434625961634 0.364441541946507 no 1200 0.364508053278214 1791 4230703
SGTC_1344 1488-0097 29.1 µM 0.344352493583458 0.365233000445387 no 1201 0.365290605597208 1746 747966
SGTC_2580 diallyl disulphide 81.36 µM 0.343633344000798 0.365506496630571 no 1202 0.365561022610842 1707 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_954 1189-0853 2.85 µM 0.343300351330186 0.365633158585096 no 1203 0.365686258266104 1733 2828194
SGTC_1969 st069479 40.1 µM 0.342859736961474 0.365800779618595 no 1204 0.365851991512572 1798 3895485
SGTC_1632 st005650 90 µM 0.342754819030388 0.365840696875203 no 1205 0.36589145916803 1714 2759605
SGTC_1033 k072-0102 21.3 µM 0.341847326845264 0.366186023486688 no 1206 0.366232895552469 1821 5965931
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.34151103060929 0.366314021323168 no 1207 0.366359451129811 1703 689007
SGTC_79 0052-0007 94.094 µM 0.338237412886082 0.367560769339225 no 1208 0.367592142074077 1813 2801472
SGTC_1570 verbenone 133 µM 0.33757578965356 0.367812916811884 no 1209 0.36784144463771 1866 29025 A natural terpanoid with antifungal properties.
SGTC_1790 st045711 43.5 µM 0.336747860184869 0.368128524561831 no 1210 0.368153490559252 1837 585119
SGTC_1388 3346-4487 254 µM 0.336708679346551 0.368143462554286 no 1211 0.368168259942104 1771 3345614
SGTC_861 0443-0273 110 µM 0.335962468859068 0.368427999006844 no 1212 0.368449584314071 1775 6149169
SGTC_166 k072-0058 166.424 µM 0.335150589833185 0.368737657407516 no 1213 0.368755746106726 1827 5846229
SGTC_104 0074-0074 590.992 µM 0.334891552671568 0.368836474597659 no 1214 0.368853447267285 1815 3943124
SGTC_2502 avocadyne acetate 18.59 µM 0.334529844674078 0.368974473044398 no 1215 0.368989887011877 1687 3952079
SGTC_581 0958-0271 211 µM 0.331728977557232 0.370043627448211 no 1216 0.370046958806668 1682 4591145
SGTC_81 0411-0046 9.971 µM 0.330965926956627 0.370335075698595 no 1217 0.370335111413661 1710 12925265
SGTC_224 benfluorex 43.875 µM 0.330376462983007 0.370560273275447 no 1218 0.370557761927359 1832 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2748 diazoxide 86.69 µM 0.329270914046794 0.370982754431685 no 1219 0.370975463340276 1785 3019 A potassium channel activatior.
SGTC_2808 7946468 45.46 µM 0.327468498325588 0.371671873836034 no 1220 0.371656782681112 1770 2970879
SGTC_3159 9100096 49.47 µM 0.327294818694293 0.371738298710233 no 1221 0.371722455458551 1689 25236875
SGTC_1036 k216-0215 33.5 µM 0.327038178000254 0.371836459557846 no 1222 0.371819504801031 1684 622330
SGTC_2358 9037157 4 µM 0.326637615254446 0.371989684874085 no 1223 0.371970994916503 1767 2388925
SGTC_390 dec-rvkr-cmk 16.7 µM 0.325248282651833 0.372521296484992 no 1224 0.372496584558906 1775 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_962 1254-0300 21.5 µM 0.325181543774851 0.372546839446975 no 1225 0.372521838108988 1745 7340576
SGTC_1870 st057514 26.5 µM 0.324277916052386 0.372892739907037 no 1226 0.37286381877446 1719 5393161
SGTC_729 4092-0585 94.1 µM 0.322570636140555 0.373546550693881 no 1227 0.373510217422077 1693 2169061
SGTC_653 0203-0016 55.2 µM 0.321113462787813 0.374104870137805 no 1228 0.374062204156108 1790 295302
SGTC_336 4111-0029 111 µM 0.32067771733884 0.374271878410992 no 1229 0.374227317589047 1714 3131175
SGTC_1167 k781-0610 148 µM 0.320271297069594 0.374427668483451 no 1230 0.374381339870371 1747 4525169
SGTC_172 1112-0046 2.638 µM 0.317912849594767 0.37533211866425 no 1231 0.375275522658163 1743 2802135 YIL048W NEO1
SGTC_2337 9009472 200 µM 0.317430047280921 0.37551735511961 no 1232 0.375458655383543 1843 5742383
SGTC_1707 st032323 6.317 µM 0.317035777941616 0.37566864547644 no 1233 0.375608227308211 1768 3132057 YMR211W DML1
SGTC_2655 perillic acid 100 µM 0.316090475721313 0.376031457854543 no 1234 0.375966917848817 1744 5702197 An apoptosis inducer.
SGTC_1924 st058459 75.1 µM 0.315246533605674 0.376355460263566 no 1235 0.376287238345445 1780 688683
SGTC_261 5-fluorouridine 15.376 µM 0.314791032840989 0.376530370265812 no 1236 0.376460160312905 1841 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1763 st044482 94.5 µM 0.314710576434821 0.376561267756658 no 1237 0.376490706593542 1821 88505
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.314207515425871 0.376754475056643 no 1238 0.376681717526001 1753 390807
SGTC_3082 9117008 49.47 µM 0.314076752795807 0.376804701248512 no 1239 0.376731372696364 1749 41448529
SGTC_2563 tomatine 8.54 µM 0.314074682453158 0.3768054964881 no 1240 0.376732158894697 2007 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1073 triclabendazole 3.09 µM 0.312973214025876 0.377228655704356 no 1241 0.37715050633769 1772 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1662 st014054 52 µM 0.312698693172804 0.377334143373095 no 1242 0.377254794256336 1789 2838777
SGTC_582 0987-0078 156 µM 0.312397655785122 0.3774498308348 no 1243 0.377369165851181 1803 1625765
SGTC_881 0833-0569 170 µM 0.311490142468386 0.377798651072984 no 1244 0.377714017795438 1688 5418700
SGTC_174 3553-0389 74.3 µM 0.310811241806774 0.378059664818941 no 1245 0.377972061479506 1801 738071
SGTC_1380 2291-0730 164 µM 0.310807595268879 0.378061066936637 no 1246 0.377973447641004 1725 2999191
SGTC_1004 4084-0029 199 µM 0.310492792374957 0.378182116762985 no 1247 0.378093119848507 1892 716894 YLR208W SEC13
SGTC_112 phenothiazine 287.218 µM 0.310440201621827 0.378202340429114 no 1248 0.378113113345135 1913 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2908 7930301 100 µM 0.308778871320629 0.378841373088615 no 1249 0.378744871261447 1709 2223178
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.308770886188289 0.378844445380697 no 1250 0.378747908570244 1717 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1247 0448-0043 5.84 µM 0.308179629511297 0.379071953563173 no 1251 0.378972825963569 1769 3089013 YGL099W LSG1
SGTC_3022 9087993 49.47 µM 0.307252656249019 0.379428725601119 no 1252 0.379325534325026 1810 17173644
SGTC_2523 spermine 47.74 µM 0.306706117323026 0.379639124803639 no 1253 0.379533536558281 1905 1103 A DNA binding polyamine.
SGTC_542 3381-0244 89.3 µM 0.305191409087668 0.38022242289753 no 1254 0.380110187524802 1881 1112843
SGTC_738 1315-0003 72.4 µM 0.305186943071286 0.380224143116686 no 1255 0.380111888136608 1868 6251474
SGTC_2605 digitonin 300 nM 0.304990971565971 0.380299629708144 no 1256 0.380186514295193 1925 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2922 7999257 32.47 µM 0.304710223353795 0.380407779524321 no 1257 0.380293431285943 1751 2988377
SGTC_2168 5727979 200 µM 0.304584078772715 0.380456375979771 no 1258 0.380341473747751 1745 695210
SGTC_103 0844-0104 51.839 µM 0.30455985089366 0.380465709843205 no 1259 0.380350701204079 1859 5375804
SGTC_1501 4491-0275 38.4 µM 0.304374527157696 0.3805371086728 no 1260 0.380421286055387 1877 5104718
SGTC_12 0849-0099 9.267 µM 0.304359960330562 0.380542720940319 no 1261 0.38042683433881 1868 6071388
SGTC_392 N-ethylmaleimide 8.33 µM 0.304349429463895 0.38054677825963 no 1262 0.380430845401451 1735 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_864 0469-0573 172 µM 0.302805044751587 0.381141938936581 no 1263 0.381019219326466 1727 689425
SGTC_446 go6976 132 µM 0.301230984002026 0.381748825316478 no 1264 0.381619182308294 1898 3501 A protein kinase C inhibitor.
SGTC_2817 7995342 71.43 µM 0.300524305868745 0.38202138299423 no 1265 0.381888629675804 1689 18879975
SGTC_2890 9046729 58.44 µM 0.298677833622946 0.382733821960503 no 1266 0.382592935830505 1714 903329
SGTC_9 0092-0002 10.449 µM 0.297664575659721 0.383124944137938 no 1267 0.382979591486345 1803 759368
SGTC_1402 3909-7673 35.9 µM 0.297452211374376 0.383206932836415 no 1268 0.383060643743234 1757 5328014
SGTC_2349 9023730 187.07 µM 0.297376909044702 0.383236006495665 no 1269 0.383089385322498 1879 4126287
SGTC_356 1634-0012 32.5 µM 0.297070094435882 0.383354472089772 no 1270 0.383206497732563 1956 735457
SGTC_2773 thioridazine 9.09 µM 0.294820888439527 0.384223255716338 no 1271 0.384065354315539 1846 5452 An antipsychotic.
SGTC_2532 xanthone 78.9 µM 0.294314650660758 0.384418876711742 no 1272 0.384258739282372 1858 7020 An insecticide.
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.293903694886241 0.384577700375338 no 1273 0.38441574731413 1881 279621
SGTC_2986 9022445 71.43 µM 0.293723475359913 0.384647356623991 no 1274 0.384484607210479 1910 6459286
SGTC_3237 9133362 49.47 µM 0.293530104397625 0.384722100146541 no 1275 0.384558496179511 1854 43845137
SGTC_199 4063-0024 41.6 µM 0.292638191027165 0.385066906124827 no 1276 0.384899359401139 1873 306215
SGTC_2667 digitoxin 100 µM 0.292098186143123 0.385275711527759 no 1277 0.385105776745095 1908 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3214 9129694 49.47 µM 0.290762264877096 0.385792419264136 no 1278 0.385616573632374 1908 17158655
SGTC_1995 st072814 61.1 µM 0.290410170664205 0.385928636083395 no 1279 0.385751231881 1756 5769371
SGTC_1504 k297-0033 30 µM 0.288396281013416 0.386708031597648 no 1280 0.386521707090057 1729 4388117
SGTC_1133 3473-0247 50 µM 0.287941506646883 0.386884097230317 no 1281 0.386695757018205 1684 711311
SGTC_2710 st078562 53.7235 µM 0.285864281773814 0.387688589143092 no 1282 0.387491035824311 1787 17250908
SGTC_2112 5488546 200 µM 0.284239759641648 0.388318089406297 no 1283 0.38811332383018 1801 600757
SGTC_2518 prenyletin 46.28 µM 0.284115685971022 0.388366179880611 no 1284 0.388160863213227 1914 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1557 sumaresinolic acid 42.3 µM 0.28400844945863 0.388407745716441 no 1285 0.388201952713806 1760 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1682 st012968 530 nM 0.283326855062614 0.388671967686834 no 1286 0.388463146480812 1732 24207270
SGTC_1049 3226-0134 66 µM 0.282178818444047 0.389117123684406 no 1287 0.38890319953925 1826 5702385
SGTC_1406 3909-7906 11.9 µM 0.28119994600046 0.389496800581918 no 1288 0.389278523038027 1851 X1406
SGTC_1862 st057513 3.81 µM 0.281004852265143 0.389572484536729 no 1289 0.389353339079706 1785 5393163
SGTC_2167 5876490 200 µM 0.280253919048191 0.389863837901941 no 1290 0.3896413509632 1958 686534
SGTC_1290 0986-0249 10.2 µM 0.279499715999801 0.390156522223889 no 1291 0.389930677968641 1908 53329
SGTC_3116 9124943 49.47 µM 0.278928134069635 0.390378378080903 no 1292 0.390149988588212 1713 41905195 YPL160W CDC60
SGTC_1218 1348-1416 30.7 µM 0.278750438281079 0.390447356838551 no 1293 0.390218175922065 1784 6787668
SGTC_2320 7373003 200 µM 0.277839362559511 0.3908010764694 no 1294 0.390567836680233 1747 5415828
SGTC_1147 3809-1045 12.3 µM 0.271005851623074 0.393457007594315 no 1295 0.393193265839211 1814 325925
SGTC_2983 9022671 12.99 µM 0.27008297076286 0.393816080294323 no 1296 0.393548211405033 1992 6405161
SGTC_2276 7947513 42.08 µM 0.269698327082175 0.393965763391813 no 1297 0.393696173833662 1675 2105100
SGTC_2697 mebhydrolin 72.4 µM 0.269360255003194 0.394097336206326 no 1298 0.39382623405278 1934 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2929 9013348 24.6 µM 0.268699430148669 0.394354554673732 no 1299 0.39408049516913 1833 2995952
SGTC_1815 st051655 58.2 µM 0.268555164089525 0.39441071470776 no 1300 0.394136009454482 1951 5984156
SGTC_2850 9015429 58.44 µM 0.268485953553566 0.394437657832721 no 1301 0.394162642770824 1782 6457570
SGTC_1765 st044815 90.4 µM 0.267374551878913 0.394870386974334 no 1302 0.394590395535694 1766 645695
SGTC_2584 androsterone 48.74 µM 0.266559548223763 0.395187794714038 no 1303 0.394904152389894 1880 2754130 A steroid.
SGTC_710 3448-4187 58 µM 0.266142712260264 0.395350160714081 no 1304 0.395064650596591 1830 3946412
SGTC_841 0251-0215 91.2 µM 0.265819722340179 0.395475984285708 no 1305 0.395189026638717 1894 3888614
SGTC_3000 9075062 71.4286 µM 0.264791181568954 0.395876733949366 no 1306 0.395585165291852 1814 17057871
SGTC_3270 9137563 49.47 µM 0.264022610243899 0.39617626377986 no 1307 0.395881248140729 1907 17015724
SGTC_1990 st072050 59.8 µM 0.263836042996632 0.396248982558045 no 1308 0.395953129995836 1794 17233948
SGTC_2803 7707263 71.43 µM 0.262830140993581 0.396641117614856 no 1309 0.396340751439358 1797 2199229
SGTC_1451 4152-0210 104 µM 0.262321173856081 0.396839570300892 no 1310 0.396536919534589 1956 659563
SGTC_2526 patulin 37.61 µM 0.261782186729732 0.397049757288161 no 1311 0.396744686605384 1863 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2824 7998404 51.95 µM 0.261107833401384 0.397312774686248 no 1312 0.3970046754961 1861 837851
SGTC_1834 st055981 52.8 µM 0.26000441989497 0.397743238699465 no 1313 0.397430182119235 1948 471719 YDL150W RPC53
SGTC_1949 st076024 69.1 µM 0.259971910720864 0.397755923079461 no 1314 0.397442720405613 1737 2921930
SGTC_2402 5553605 200 µM 0.259575895889846 0.397910448216903 no 1315 0.397595465713946 1901 6758546
SGTC_1952 st077036 64.1 µM 0.259233377097265 0.398044112097937 no 1316 0.397727589942388 1965 2937007
SGTC_415 dibenzyl ketone 100 µM 0.258014688800915 0.39851978762774 no 1317 0.398197785461465 1962 7593
SGTC_1059 3448-6867 171 µM 0.257928137668056 0.398553575804744 no 1318 0.398231184336308 2017 3934407
SGTC_1694 st024011 44.9 µM 0.257868559896643 0.398576834455059 no 1319 0.398254175000507 1870 2787533
SGTC_106 0092-0003 11.579 µM 0.256810317035711 0.398990023335162 no 1320 0.398662602640692 1960 1072148
SGTC_925 2064-1272 59.6 µM 0.256439342724623 0.399134896361676 no 1321 0.398805806059363 1797 6815817
SGTC_1704 st028805 70.8 µM 0.255088355223844 0.399662601795407 no 1322 0.39932742895705 1836 2876101
SGTC_816 0325-0417 81.3 µM 0.254981434416193 0.399704373673298 no 1323 0.399368719294502 1835 68101
SGTC_1567 st069303 68.4 µM 0.254385432689327 0.399937240965377 no 1324 0.399598901960057 1853 5581319
SGTC_3094 9117742 49.47 µM 0.253199731195796 0.400400619026417 no 1325 0.400056937111364 1896 17149698
SGTC_2486 5283202 22.39 µM 0.252793677853902 0.400559338965465 no 1326 0.400213826704426 1776 1377751
SGTC_3317 9138495 8.753 µM 0.252616085911442 0.400628762058046 no 1327 0.400282449175474 1870 17020139
SGTC_2774 tamoxifen 10.92 µM 0.252481210358142 0.400681488833673 no 1328 0.400334567863624 1885 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_551 k048-0028 34.9 µM 0.251837850234201 0.400933021901138 no 1329 0.400583199858764 1938 6836383
SGTC_3251 9135047 49.47 µM 0.250885607014571 0.401305393662186 no 1330 0.400951276270447 1968 17682963
SGTC_628 1636-0253 16 µM 0.250501479771009 0.401455630828332 no 1331 0.401099780241031 1969 4456143
SGTC_7 0192-1582 4.227 µM 0.249919449136687 0.401683298341495 no 1332 0.401324821081278 1894 252616
SGTC_2450 5739737 12.93 µM 0.249031668461267 0.40203062750746 no 1333 0.401668142515424 1865 2262825
SGTC_907 3448-6986 75.5 µM 0.248935216734072 0.402068367278591 no 1334 0.401705446783135 1952 590582
SGTC_584 0986-0246 15.4 µM 0.247620196428931 0.402583001268088 no 1335 0.402214141402759 1968 53315 YDR232W HEM1
SGTC_2015 5119600 184 µM 0.247140085487633 0.402770935101534 no 1336 0.402399905986937 1953 2828786
SGTC_1932 st074806 40.9 µM 0.245003253011081 0.403607645226585 no 1337 0.403226956286774 1931 17251235
SGTC_2792 7535235 81.82 µM 0.244834969463393 0.40367355807501 no 1338 0.403292108033934 1792 1281891
SGTC_26 0302-0163 425.158 µM 0.243333632912408 0.40426171841499 no 1339 0.403873475965754 1890 3100915
SGTC_914 3820-6779 408 µM 0.243185299578258 0.404319840930386 no 1340 0.403930927165132 1853 2893481
SGTC_303 1348-1668 34.2 µM 0.24300530292312 0.404390373148289 no 1341 0.404000644714537 1906 5380509
SGTC_2218 6965428 192.983 µM 0.242682174863688 0.404516999622453 no 1342 0.404125808559088 1959 675684
SGTC_475 α-linolenic acid 10 µM 0.242028927387848 0.404773022859043 no 1343 0.404378874321104 1976 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2495 cafestol 54.53 µM 0.24191555896305 0.404817458798421 no 1344 0.404422796925525 1919 16667697 An anti-infammatory.
SGTC_2543 pimpinellin 60.67 µM 0.240950389552826 0.405195816692084 no 1345 0.404796783586255 1828 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3069 9117009 49.47 µM 0.24089508863983 0.405217497995737 no 1346 0.404818214383302 1996 41904981
SGTC_1900 st060200 72.8 µM 0.240643670775352 0.40531607267617 no 1347 0.40491565010255 1838 688945
SGTC_3348 9149464 3.537 µM 0.239479374232119 0.405772642560401 no 1348 0.405366944099178 1964 1951442
SGTC_776 4476-4378 112 µM 0.23935398040505 0.405821822438327 no 1349 0.405415555626698 1850 2892008
SGTC_2248 tofa 1.1 µM 0.237661481695674 0.406485771214434 no 1350 0.406071830442388 1883 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2719 novobiocin 32.65 µM 0.237479537500208 0.406557161980575 no 1351 0.406142395960538 1977 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1170 0310-0127 64.8 µM 0.237087661090342 0.406710935921326 no 1352 0.406294392266343 1917 774975
SGTC_3148 9097893 49.47 µM 0.235967122023929 0.40715071943313 no 1353 0.406729091324665 1777 17174100
SGTC_3136 9095672 49.47 µM 0.235563094029772 0.407309319047023 no 1354 0.406885857134609 2040 17217380
SGTC_574 1315-0397 40 µM 0.232820462725863 0.408386328720345 no 1355 0.407950411276624 1947 6794277
SGTC_319 1348-1596 45.5 µM 0.231907680915675 0.408744924899407 no 1356 0.408304859320625 2008 5380505
SGTC_2255 7941087 197.44 µM 0.230467504418485 0.409310869042413 no 1357 0.408864255799367 2014 935561
SGTC_664 1222-0054 14.9 µM 0.230428296974364 0.409326278985823 no 1358 0.408879487441435 1888 6813991
SGTC_1860 st056228 74.6 µM 0.22965166401284 0.409631552671043 no 1359 0.409181228765183 1867 688679
SGTC_1410 3909-8106 77.9 µM 0.229301345284848 0.409769271555499 no 1360 0.409317353974694 1989 1039210
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.228757621703132 0.409983044674901 no 1361 0.409528653187438 1869 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1152 3909-8331 15.9 µM 0.222488455933192 0.412449778976554 no 1362 0.411966829457364 1894 16001939
SGTC_2783 7738165 71.43 µM 0.221627322179576 0.412788882680137 no 1363 0.412302005677428 1814 17201110
SGTC_2862 9027634 71.43 µM 0.221327424517724 0.412906993924152 no 1364 0.412418748876067 1813 5012562
SGTC_1187 1391-0724 117 µM 0.221297159159492 0.412918914025493 no 1365 0.412430530908163 1925 6997986
SGTC_1381 2324-0066 62.1 µM 0.219224919293904 0.413735262244416 no 1366 0.413237422396156 1925 10885928
SGTC_2602 kawain 100 µM 0.216722257290033 0.414721669986041 no 1367 0.414212400703169 2045 5369129
SGTC_2977 9011197 71.43 µM 0.216117582250674 0.414960079597151 no 1368 0.41444804745046 1998 2704722
SGTC_2581 avocatin a 64 µM 0.215875458269176 0.415055552361419 no 1369 0.414542413761161 1914 6710728 A skin care supplement.
SGTC_3338 9144300 39.5675 µM 0.215515978188484 0.415197309476242 no 1370 0.414682527975608 1973 4901274
SGTC_1473 k844-0725 134 µM 0.21321575320969 0.416104639110266 no 1371 0.41557934074301 2013 54682906
SGTC_442 cape 100 µM 0.2125625008228 0.416362397954506 no 1372 0.415834111492167 2042 5281787
SGTC_747 3448-8087 38.7 µM 0.212166766745384 0.416518563312228 no 1373 0.415988466401313 1882 5168703
SGTC_3323 9138564 53.9225 µM 0.208850223837041 0.417827859656426 no 1374 0.417282581400528 2054 43912313 YNL103W MET4
SGTC_2114 5491910 81.25 µM 0.208008354876235 0.418160356140148 no 1375 0.417611221893853 2005 2849228
SGTC_657 3534-0529 86.7 µM 0.207846190662036 0.41822440968808 no 1376 0.417674532576688 2030 1049549
SGTC_730 1436-0052 41.2 µM 0.207545000419405 0.41834338314223 no 1377 0.417792126202697 2001 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_100 0086-0128 49.5915 µM 0.207091603466891 0.418522494003906 no 1378 0.41796915971259 1842 93297
SGTC_268 camptothecin 39.6153 µM 0.206576805872975 0.41872588117998 no 1379 0.418170187885908 1999 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2751 anetholtrithion 17.25 µM 0.206219327482017 0.418867127182582 no 1380 0.418309795578896 2024 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3088 9117578 49.47 µM 0.205317853306616 0.419223361896031 no 1381 0.418661898130851 2066 678341
SGTC_751 0833-0568 350 µM 0.204984699737423 0.419355030658542 no 1382 0.418792039523044 1947 6954252
SGTC_944 3370-0224 231 µM 0.204782889854197 0.419434794237992 no 1383 0.418870877818563 1891 4580514
SGTC_2663 amphotericin b 100 µM 0.204261134796945 0.419641028666918 no 1384 0.419074719794914 1952 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2787 5284540 71.43 µM 0.202726940683766 0.420247578154801 no 1385 0.41967423238519 1924 736958
SGTC_3070 9117005 49.47 µM 0.20201109187905 0.420530656615981 no 1386 0.419954026440279 2037 8779016
SGTC_2788 5282734 71.43 µM 0.201333460082008 0.420798660246239 no 1387 0.420218920418357 2039 743706
SGTC_1107 amlodipine 47 µM 0.201192941435853 0.42085424002335 no 1388 0.420273855283914 1972 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_755 1995-0008 37.3 µM 0.199565569911849 0.42149803399717 no 1389 0.42091017864791 2054 689533
SGTC_3347 9188721 44.724 µM 0.199500363732145 0.421523834179406 no 1390 0.420935679427131 1995 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_618 k072-0232 33.2 µM 0.198624591572365 0.421870384269286 no 1391 0.421278207790364 1969 5872756 YGL099W LSG1
SGTC_1963 st076565 50.3 µM 0.198365611283873 0.421972876458023 no 1392 0.42137951051059 1938 4914280
SGTC_3027 9089541 49.47 µM 0.195048633010747 0.423286045046446 no 1393 0.422677437528249 1953 9943819
SGTC_1174 0739-0097 51.1 µM 0.194624366761967 0.42345407090747 no 1394 0.422843512949844 1950 728447
SGTC_3325 9138760 55.175 µM 0.194594537670769 0.423465884906627 no 1395 0.422855189810705 1913 43844959
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.194028355797049 0.423690137833593 no 1396 0.423076839540698 2041 5282309
SGTC_3258 9138477 49.47 µM 0.193686503126977 0.423825550575927 no 1397 0.423210680331552 1975 4970355
SGTC_347 4534-1311 26.2 µM 0.192960176089503 0.424113288966082 no 1398 0.423495078388858 1976 2862016
SGTC_2728 chlorpromazine 9.18 µM 0.192464359202425 0.424309732756028 no 1399 0.42368924160529 2043 2726 A thorazine and dopamine antagonist.
SGTC_2936 9038235 15.59 µM 0.192434650223876 0.424321504119228 no 1400 0.423700876309442 2007 4749415
SGTC_280 3448-3607 3.04 µM 0.191634808406141 0.424638444715851 no 1401 0.424014137323192 2071 626179
SGTC_1401 3807-4679 7.6 µM 0.189990071627301 0.425290331311978 no 1402 0.424658455264581 1984 3291456
SGTC_2801 7907800 81.82 µM 0.189966374653962 0.425299725035089 no 1403 0.424667739918648 1952 6620925
SGTC_2658 polymyxin b sulfate 77.05 µM 0.189885165281379 0.425331917584384 no 1404 0.424699558684405 1980 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1948 st076329 66.6 µM 0.18917087628756 0.425615093314956 no 1405 0.424979446438529 2080 24208413
SGTC_2575 plumbagin 510 nM 0.188996377064912 0.425684278357727 no 1406 0.425047828152106 1898 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1849 st056239 19.2 µM 0.185911063636558 0.42690791214549 no 1407 0.426257252964805 1868 5393181
SGTC_3332 9141069 11.198 µM 0.18544696346956 0.42709203521845 no 1408 0.42643923782833 1907 17332883
SGTC_769 0302-0231 76 µM 0.184592421039542 0.427431100489747 no 1409 0.426774365460313 2057 571869 YER009W NTF2
SGTC_2680 butyl paraben 22.24 µM 0.184463440490588 0.427482282043294 no 1410 0.426824952620721 2083 7184 An antifungal and steroid mimetic.
SGTC_294 k038-0071 157 µM 0.183902856034885 0.427704745128376 no 1411 0.427044832116202 1969 24152826
SGTC_3053 9095903 49.47 µM 0.18309811385092 0.428024140258093 no 1412 0.427360517843388 2109 17174018
SGTC_457 grayanotoxin iii 135 µM 0.181684593686253 0.428585268093153 no 1413 0.427915128598834 2016 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1332 1480-0653 17.5 µM 0.180140575873357 0.429198364808738 no 1414 0.428521104341349 2115 5749438
SGTC_3068 9116768 49.47 µM 0.179621043025687 0.429404698767699 no 1415 0.428725041712193 1989 41904888
SGTC_164 4100-3994 89.624 µM 0.179336016551593 0.42951790604578 no 1416 0.428836934063461 2117 4615967
SGTC_2949 9072542 2.23 µM 0.177945612514899 0.430070231915689 no 1417 0.429382844417911 1962 16457352
SGTC_66 0109-0187 42.4 µM 0.177285981758886 0.430332312413161 no 1418 0.429641880659653 1959 759417
SGTC_1265 0819-1001 68.8 µM 0.176927523879147 0.430474745606254 no 1419 0.42978265936946 2058 3106768
SGTC_614 0462-0418 107 µM 0.176370746218481 0.430695999069953 no 1420 0.430001342761013 2049 5188303
SGTC_883 0850-0245 24.6 µM 0.175714187774588 0.430956931577407 no 1421 0.430259244250296 2064 6823229 YPR165W RHO1
SGTC_409 arachidonic acid 100 µM 0.175114803592444 0.431195167945358 no 1422 0.430494713209023 2001 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_997 3996-0078 137 µM 0.173694463384904 0.431759808321641 no 1423 0.43105279448178 1991 735687
SGTC_334 1502-1024 68.5 µM 0.172911104393994 0.432071283671399 no 1424 0.431360651542546 2008 3296216
SGTC_2214 7179297 48.276 µM 0.172691086988679 0.43215877351427 no 1425 0.431447125042994 2046 769744
SGTC_96 0929-0093 37.281 µM 0.172124717146099 0.432384005575841 no 1426 0.431669740641026 1959 6991579
SGTC_3220 9131269 49.47 µM 0.171572174896245 0.432603759903863 no 1427 0.431886942122983 2102 17722206
SGTC_148 3253-0744 288.01 µM 0.171058992411281 0.432807878938849 no 1428 0.432088689931483 2139 6893655
SGTC_440 fluspirilene 35.1 µM 0.169195264396107 0.433549329714652 no 1429 0.432821527278106 2057 3396 An atypical antipsychotic.
SGTC_1627 st003713 25.6 µM 0.16889432990248 0.433669073110326 no 1430 0.432939879605761 1982 16195070 YER133W GLC7
SGTC_2183 6420625 130.508 µM 0.168684156526464 0.433752705798129 no 1431 0.433022540725133 2074 2897619
SGTC_1027 k015-0025 8.67 µM 0.166801371545119 0.434502039920141 no 1432 0.433763169735043 2042 3598955
SGTC_3293 9120939 62.045 µM 0.166126972082248 0.434770503176764 no 1433 0.434028514212923 2049 934087
SGTC_1628 st004252 77.7 µM 0.164223949265221 0.4355282155429 no 1434 0.434777424134125 2092 692968
SGTC_2820 7989630 71.43 µM 0.163756095600154 0.435714533703161 no 1435 0.434961577820263 2141 2984098
SGTC_2686 alizarin 95.37 µM 0.162894048705344 0.436057872813117 no 1436 0.435300928344704 1976 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_682 0kpi-0099 17 µM 0.161353522672323 0.436671558859201 no 1437 0.43590748523595 1983 1714895 YML126C ERG13
SGTC_2745 rifampicin 24.3 µM 0.160866999678328 0.436865402565938 no 1438 0.436099077092769 2148 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2331 7980721 200 µM 0.158581071431939 0.437776379397888 no 1439 0.436999471435937 2096 2981221
SGTC_1526 st051518 75 µM 0.157621341051539 0.438158945015479 no 1440 0.437377593031371 1970 673993
SGTC_328 k915-0120 63.5 µM 0.155761035304387 0.438900660305225 no 1441 0.438110692501391 2120 6624543
SGTC_898 1000-0849 28.3 µM 0.153969937726022 0.43961498469101 no 1442 0.438816719557648 2142 6751807
SGTC_879 0831-1030 162 µM 0.153956910486919 0.439620180929282 no 1443 0.43882185543959 1990 1549252
SGTC_20 0481-0013 4.944 µM 0.153697490987187 0.439723659012842 no 1444 0.438924131588953 2008 182045
SGTC_1722 st034304 3.6505 µM 0.153417276301703 0.439835436573211 no 1445 0.439034610822524 2011 4036148 YLR033W RSC58
SGTC_250 brefeldin a 552.239 µM 0.151962773613375 0.440415714152625 no 1446 0.439608148473168 2039 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1228 0124-0032 52.5 µM 0.150003791145795 0.441197457290076 no 1447 0.440380812101526 2108 X1228
SGTC_451 chloral hydrate 100 µM 0.14930949839831 0.441474573934369 no 1448 0.440654710324781 2047 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1323 1348-1351 11.2 µM 0.148302201546429 0.441876672425849 no 1449 0.441052138995238 1992 6989654
SGTC_1201 1889-3372 45.9 µM 0.147775298490108 0.442087028475647 no 1450 0.441260052114689 2024 5392199
SGTC_2531 methyl deoxycholate 70.07 µM 0.147029556328476 0.442384779788556 no 1451 0.441554345629479 2037 16667744 Haematoxylin.
SGTC_838 0109-0203 71.4 µM 0.145964280467793 0.442810167241756 no 1452 0.441974793211653 2112 759422
SGTC_1140 3229-1848 2.98 µM 0.145506526859758 0.442992978337794 no 1453 0.442155481452503 2135 2849525
SGTC_3182 9108849 49.47 µM 0.145464348018351 0.443009823732117 no 1454 0.442172131235236 2062 17133045
SGTC_3096 9117468 49.47 µM 0.144219787562616 0.443506922777294 no 1455 0.442663458036921 2155 41316311
SGTC_2470 5664817 21.68 µM 0.143175815971196 0.44392397175579 no 1456 0.443075664542122 2188 2859561
SGTC_1609 st001574 46.4 µM 0.14289113053068 0.444037709566946 no 1457 0.443188081750983 2089 3960012
SGTC_756 0508-1999 28.3 µM 0.141722870204102 0.444504502266299 no 1458 0.443649454734525 1953 6753853
SGTC_1558 st069300 45.6 µM 0.139530442511387 0.445380720853195 no 1459 0.444515500787896 2163 24208000
SGTC_2377 9073351 62.6 µM 0.139236868985496 0.445498069857135 no 1460 0.444631487505778 1967 7337946 YHR072W ERG7
SGTC_2217 6934799 96.0675 µM 0.13884534239096 0.445654580689701 no 1461 0.444786181461982 2155 675606
SGTC_2511 berberine 10.47 µM 0.138640454568407 0.445736486967422 no 1462 0.444867136935304 2043 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1679 SEC14.276 6.7 µM 0.13823644191244 0.445898002483808 no 1463 0.445026777539078 2172 1005053 YMR079W SEC14
SGTC_2696 st077691 74.316 µM 0.138046086251546 0.445974105670794 no 1464 0.445101997315647 2082 757133
SGTC_2711 st079103 59.1 µM 0.137711617221344 0.446107829440465 no 1465 0.445234168834357 2132 54693780
SGTC_2269 7935389 174.42 µM 0.135529591167005 0.44698037312752 no 1466 0.446096584861444 2055 97605
SGTC_2261 9010538 184.68 µM 0.135377950621197 0.447041020397545 no 1467 0.446156528244071 2005 6457250
SGTC_222 nsc-310342 10.666 µM 0.135252632584775 0.447091141151817 no 1468 0.44620606728922 2176 432556
SGTC_1028 k015-0029 4.8 µM 0.133547032082933 0.447773377111965 no 1469 0.446880385564866 2164 4588309
SGTC_3212 9128307 49.47 µM 0.132724951148398 0.448102262757544 no 1470 0.447205454638406 1858 27243542
SGTC_2232 chlorophetanol 41.5365 µM 0.132599006060868 0.448152652111132 no 1471 0.447255259264072 2172 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1836 st055642 81 µM 0.131613592298811 0.448546934990511 no 1472 0.447644966977685 2022 8571
SGTC_3349 9149703 23.001 µM 0.131446919647285 0.44861362893996 no 1473 0.447710887056407 2172 4910494
SGTC_2077 5212015 200 µM 0.130054115638709 0.449171015122858 no 1474 0.448261806063037 2177 780900
SGTC_2060 5238662 140 µM 0.129517356630742 0.449385847530713 no 1475 0.448474146008211 2068 790130
SGTC_2002 4023503 131 µM 0.128978914912544 0.449601368333906 no 1476 0.448687166459268 2218 4736863 YCR052W RSC6
SGTC_2769 toremifene 3.73 µM 0.128425970255237 0.44982270966797 no 1477 0.448905940017501 2120 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1757 st041620 31.8375 µM 0.127727201842965 0.450102445936521 no 1478 0.449182431223364 2049 5289815
SGTC_1500 4488-1866 171 µM 0.12755407246614 0.450171758239114 no 1479 0.449250939499492 2179 2900003
SGTC_601 0986-0029 62.9 µM 0.127120184375009 0.450345471900751 no 1480 0.449422638119948 2090 24747981
SGTC_1048 3161-0300 24.5 µM 0.127009548747452 0.450389768071548 no 1481 0.449466420475422 2150 2165101
SGTC_2611 pyromycin 23.93 µM 0.126300818956483 0.450673543161664 no 1482 0.449746904009 2073 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2061 5245884 80.95 µM 0.12609505257095 0.450755936659867 no 1483 0.449828341844941 2127 573863
SGTC_1258 0671-0043 57.1 µM 0.126004703933154 0.450792114961321 no 1484 0.449864100527932 2055 4298767
SGTC_1441 4106-0040 13 µM 0.125069307011808 0.451166699886243 no 1485 0.450234340961502 2187 2904180
SGTC_3299 9121982 43.1275 µM 0.124639797412132 0.451338713995841 no 1486 0.45040436013596 2065 17594604 YPL160W CDC60
SGTC_1297 1068-0111 14.1 µM 0.123847117611392 0.451656197948996 no 1487 0.450718162251066 2097 767057
SGTC_3032 9089427 49.47 µM 0.123481945736369 0.451802466930598 no 1488 0.450862735043756 2086 17173707
SGTC_90 0870-0863 4.608 µM 0.122436697614276 0.452221175411393 no 1489 0.451276588316851 2117 1738164
SGTC_1197 1601-0112 267 µM 0.122358507649992 0.452252499112998 no 1490 0.451307548816444 2075 7350313
SGTC_2879 9041815 71.43 µM 0.121322701786448 0.452667481537107 no 1491 0.451717719703736 2205 4942971
SGTC_2691 st077356 60.2 µM 0.118354709111844 0.453856854794921 no 1492 0.452893305183964 2164 2839272
SGTC_803 4488-1585 147 µM 0.116903795965861 0.454438435194577 no 1493 0.453468145018188 2180 747204
SGTC_1026 k007-1105 30.6 µM 0.116267256655496 0.454693614925366 no 1494 0.453720367492839 2173 7066794
SGTC_2003 4023581 200 µM 0.115018115533639 0.455194432431741 no 1495 0.454215381608597 2105 16641307
SGTC_1098 clofazimine 15.1 µM 0.113942583727635 0.455625701933827 no 1496 0.454641654216175 2183 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2018 5133068 143 µM 0.113422695025724 0.455834187018558 no 1497 0.454847723890877 2165 785362
SGTC_3203 9113543 49.47 µM 0.112418995779693 0.45623672352778 no 1498 0.455245597172347 2119 17018012
SGTC_87 0100-0052 35.5 µM 0.112261909118087 0.456299727667256 no 1499 0.455307871478222 2184 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2258 7960471 200 µM 0.111900728485187 0.456444593749317 no 1500 0.455451059492487 2049 2974708
SGTC_462 ag-879 158 µM 0.111021129443072 0.456797416654686 no 1501 0.455799795717887 2209 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_3337 9144342 33.5465 µM 0.110545238847749 0.456988319099239 no 1502 0.455988487138687 2178 17682949
SGTC_3242 9133940 49.47 µM 0.11014521081604 0.457148797127323 no 1503 0.456147106606543 2181 17248444
SGTC_2317 5986382 200 µM 0.109976193774195 0.4572166032811 no 1504 0.45621412749479 2173 877883
SGTC_1371 2421-0008 32.7 µM 0.109892320646537 0.457250251913817 no 1505 0.456247386446928 2103 2827552
SGTC_438 sphingosine 6.67 µM 0.107728048289368 0.458118630614667 no 1506 0.457105709833645 2078 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1299 1079-1439 3.74 µM 0.105965524088401 0.45882596238166 no 1507 0.457804852964619 2137 323161
SGTC_1213 1315-0166 115 µM 0.104484662098967 0.459420359066536 no 1508 0.458392369763138 1989 768401
SGTC_552 k242-0005 476 µM 0.104343971999173 0.459476834786982 no 1509 0.458448191865402 2121 4088318
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.104190264655517 0.459538536814941 no 1510 0.458509179801663 2199 2333 A French combination drug.
SGTC_1272 0839-0021 27 µM 0.103389517770464 0.45985999266276 no 1511 0.458826915585205 2155 5027250
SGTC_2912 7964298 10.93 µM 0.102615853122448 0.460170601408176 no 1512 0.459133930145434 2123 2975850
SGTC_951 1171-0579 82.7 µM 0.102356956154981 0.46027454808482 no 1513 0.45923667408877 2219 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2950 9072895 21.46 µM 0.102047238199149 0.460398902864875 no 1514 0.459359590051491 2108 17332245
SGTC_2943 9068529 45.32 µM 0.100777767000861 0.460908648276676 no 1515 0.459863438167706 2233 3270634
SGTC_1754 st042065 16.137 µM 0.099623931122597 0.461372017056429 no 1516 0.460321447025406 2148 1126236 YIL048W NEO1
SGTC_3162 9099653 49.47 µM 0.099496267317531 0.461423288778787 no 1517 0.460372125722421 2222 25237511
SGTC_1190 1486-1332 13 µM 0.0993550929305562 0.461479987302486 no 1518 0.460428168464234 2215 4150046
SGTC_1132 3456-3614 2.5 µM 0.0993503811338777 0.461481879669992 no 1519 0.460430038944602 2233 3125502
SGTC_606 k015-0008 38.6 µM 0.0990055808014929 0.461620361894315 no 1520 0.460566919519381 2213 1970475
SGTC_3239 9133757 49.47 µM 0.0985740089523024 0.461793700735132 no 1521 0.46073825367126 2204 17036923
SGTC_2092 5303694 80.6725 µM 0.0980240764552708 0.462014589095461 no 1522 0.460956587592888 2123 1963699
SGTC_105 0111-0055 734.78 µM 0.09707206889495 0.462397004392803 no 1523 0.461334580938938 2155 5179370
SGTC_1068 loratadine 26.9 µM 0.0965106891300479 0.462622523338978 no 1524 0.461557492429095 2120 3957 A H1 histamine antagonist.
SGTC_3086 9117350 49.47 µM 0.0961463546474333 0.462768891173205 no 1525 0.461702168062161 2246 2679265
SGTC_70 0141-0289 43.283 µM 0.0961315484021821 0.462774839544931 no 1526 0.461708047664828 2122 352408
SGTC_2219 9098279 200 µM 0.0951061869004966 0.463186796120584 no 1527 0.46211524195926 2242 902349
SGTC_2612 dictamnine 15.46 µM 0.0925070336915705 0.464231226397093 no 1528 0.463147601553942 2135 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2365 9042475 200 µM 0.0913602565998437 0.464692120177254 no 1529 0.463603170137452 2146 6464479
SGTC_935 2996-0153 430 µM 0.0910511633758916 0.46481635397157 no 1530 0.463725968680242 2262 23738523
SGTC_380 3970-0968 6 µM 0.0901051607392632 0.465196601933872 no 1531 0.464101824113813 2201 2891601
SGTC_2762 leflunomide 42.06 µM 0.0896891922124579 0.465363811532026 no 1532 0.464267102345952 2172 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2461 5755302 26.15 µM 0.0893068047750103 0.465517527714963 no 1533 0.464419043126559 2250 2788904
SGTC_3301 9125354 19.7965 µM 0.0877124899043888 0.46615848260834 no 1534 0.465052596189382 2221 41905162
SGTC_2127 5253358 187.912 µM 0.0870337929977005 0.466431362662997 no 1535 0.465322325542613 2189 20612
SGTC_697 0508-1955 564 µM 0.0870006794403661 0.46644467685963 no 1536 0.465335486020683 2247 6243113
SGTC_1407 3909-7909 12.3 µM 0.0867191582312204 0.466557871551193 no 1537 0.465447373859326 2208 4411780
SGTC_129 0088-0017 176.636 µM 0.0867014496320698 0.466564991955761 no 1538 0.465454412059481 2257 182446
SGTC_343 4130-2827 29.8 µM 0.0862757884418355 0.466736148171291 no 1539 0.465623592361223 2135 1118244
SGTC_1205 4161-2785 76 µM 0.0860794997165003 0.46681507695099 no 1540 0.465701609991924 2068 3498106
SGTC_3138 9097216 49.47 µM 0.0856831798215159 0.466974443342104 no 1541 0.465859136753532 2292 25237486
SGTC_1515 3460-0031 42.1 µM 0.0851902134667868 0.467172680162922 no 1542 0.466055085409959 2202 2876596
SGTC_1684 st024538 14.6195 µM 0.0850992837177139 0.467209246681932 no 1543 0.466091229876682 2173 6732859
SGTC_80 0159-0065 512.242 µM 0.084472292696578 0.467461392572478 no 1544 0.466340465656608 2254 1548079
SGTC_1485 3909-9022 254 µM 0.084416079562302 0.467483999453826 no 1545 0.466362811637789 2235 714516
SGTC_2669 eugenol 100 µM 0.084030781290096 0.46763895524689 no 1546 0.466515979190029 2257 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1559 coumarin 343 70.1 µM 0.0820794108368246 0.4684238146854 no 1547 0.467291782821553 2228 108770 A hepatotoxic, DNA x-linker.
SGTC_1961 st076550 68.7 µM 0.0819689298388239 0.468468254875703 no 1548 0.467335710342583 2197 1579337
SGTC_537 1334-0398 209 µM 0.0813444404300478 0.468719458639699 no 1549 0.467584016356711 2283 5846986
SGTC_1743 st037606 46.3785 µM 0.0813378337903372 0.468722116257945 no 1550 0.467586643319739 2211 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1895 st058434 18.3 µM 0.0813050151292272 0.468735318068982 no 1551 0.467599692850415 2274 5393175
SGTC_427 1354-0053 47.3 µM 0.0765437429856681 0.470650969921753 no 1552 0.469493257080028 2208 6813657
SGTC_857 0438-0306 1.35 µM 0.075808555647516 0.470946827108642 no 1553 0.469785704646337 2181 4686136
SGTC_252 miconazole 1.30953 nM 0.0740290857774257 0.47166299493479 no 1554 0.470493620824234 2289 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1724 st037281 8.293 µM 0.0738301490486764 0.47174306501454 no 1555 0.47057276850619 2231 574124 YDL195W SEC31
SGTC_1568 digitonin 820 nM 0.0734675240154878 0.47188902096546 no 1556 0.470717043148266 2288 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2451 5856223 45.7 µM 0.0730787420129875 0.472045509244522 no 1557 0.47087172891785 2227 2179896
SGTC_1468 k284-1086 134 µM 0.0698780464995056 0.473333979993781 no 1558 0.472145363381608 2210 15996457
SGTC_396 dithiazanine 1.25 µM 0.0693243884775629 0.473556889038881 no 1559 0.472365706618133 2164 10578 An antihelmenthic.
SGTC_823 0417-1665 178 µM 0.0686761035634888 0.473817906470656 no 1560 0.472623719938863 2203 3429856
SGTC_2234 tolnaftate 200 µM 0.0679220606577988 0.474121519127283 no 1561 0.472923838719393 2286 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2020 4017018 200 µM 0.0671891871739543 0.474416622398464 no 1562 0.473215546529178 2230 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2150 5556613 200 µM 0.0667055913535498 0.474611357715145 no 1563 0.473408041486309 2228 743190
SGTC_2001 4023502 57.655 µM 0.0663863447918032 0.474739915875765 no 1564 0.47353512074865 2248 108941 YCR052W RSC6
SGTC_2326 6164455 177.58 µM 0.0635672568805795 0.475875253767894 no 1565 0.474657402108066 2246 2888790
SGTC_1607 st000305 50.6 µM 0.063272739464051 0.475993876918819 no 1566 0.474774661505847 2275 5457690
SGTC_1085 doxorubicin 7.67 µM 0.0628439535266245 0.476166583371932 no 1567 0.474945382582773 2306 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2744 captopril 92.04 µM 0.0627889583518628 0.476188734659891 no 1568 0.474967279239469 2291 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3047 9092122 49.47 µM 0.0627717289249711 0.476195674447441 no 1569 0.47497413925406 2250 17173831
SGTC_120 rhodamine 6G 52.259 µM 0.0619987426963537 0.476507030575871 no 1570 0.475281916629959 2304 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_361 000s-0510 1.45 µM 0.0619870514134461 0.47651173989401 no 1571 0.475286571823191 2234 660
SGTC_2442 5158906 48.48 µM 0.0611012679925528 0.476868548205187 no 1572 0.475639279663788 2268 1893835
SGTC_2160 5660466 132.927 µM 0.0604137138909258 0.477145519245295 no 1573 0.475913068251408 2314 2859134
SGTC_323 4013-0906 34.3 µM 0.0594736053754031 0.47752424595216 no 1574 0.476287444056582 2307 2910086
SGTC_327 1273-0057 3.96 µM 0.0589292231478609 0.477743561946471 no 1575 0.476504240892515 2302 3108138
SGTC_2007 4011539 71.82 µM 0.0587300804058546 0.477823792536025 no 1576 0.476583549991653 2276 45595301
SGTC_470 aa-861 153 µM 0.0573530323405659 0.478378601815304 no 1577 0.477131988070115 2245 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2306 7482397 179.52 µM 0.0572919894987464 0.478403196803981 no 1578 0.477156300663784 2286 891448
SGTC_1275 0867-0008 21.1 µM 0.0569456509696837 0.478542742847845 no 1579 0.477294244536976 2249 3422836
SGTC_1066 ketoconazole 628 nM 0.0555445266325282 0.479107307799565 no 1580 0.477852328778528 2284 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.0548444298373306 0.479389418536256 no 1581 0.47813120187739 2295 616764
SGTC_1472 k841-0093 193 µM 0.0547093474767527 0.479443852465264 no 1582 0.478185011154164 2295 X1472
SGTC_685 1278-0033 54.9 µM 0.0542673139437033 0.479621980706002 no 1583 0.47836109542912 2286 3590572
SGTC_617 3770-0098 35 µM 0.0538703030176625 0.479781969454473 no 1584 0.478519248527988 2253 5962639
SGTC_208 k072-0098 12.366 µM 0.0531677165547336 0.480065107988742 no 1585 0.478799138838045 2323 5948901
SGTC_2045 5106652 78.05 µM 0.0531582593911931 0.480068919243287 no 1586 0.478802906372572 2303 673349
SGTC_3175 9106517 49.47 µM 0.0521812224352885 0.480462676712879 no 1587 0.479192147436601 2262 41468073
SGTC_1502 4534-4282 27.7 µM 0.0521714488139685 0.480466615695019 no 1588 0.479196041243577 2254 3278949
SGTC_1056 3448-1962 115 µM 0.0512407959966607 0.480841697720807 no 1589 0.479566822010514 2260 715507
SGTC_1188 1403-0014 4.57 µM 0.0508248603593886 0.481009338221147 no 1590 0.479732540386104 2283 9614867
SGTC_94 0334-0113 514.748 µM 0.0507124500528745 0.481054645135564 no 1591 0.479777327854022 2308 6795178
SGTC_3020 9089140 49.47 µM 0.0499639799054487 0.481356321842778 no 1592 0.480075546162008 2272 17217859
SGTC_330 1488-0319 80.1 µM 0.0492255310530125 0.481653969853333 no 1593 0.480369782544126 2216 6846614
SGTC_459 nigericin 15.3 µM 0.0480408453542932 0.482131504709633 no 1594 0.480841845142374 2267 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_141 0443-0274 32.331 µM 0.0479822608640257 0.482155120197661 no 1595 0.480865190050721 2313 1627241
SGTC_2406 ethylparaben 405.7 µM 0.0471680256086328 0.482483345986748 no 1596 0.481189655506857 2191 8434 A possible steroid mimic.
SGTC_1772 st048439 82.2 µM 0.0471006807076632 0.482510493876062 no 1597 0.481216492407591 2210 2927068 YDL195W SEC31
SGTC_275 trichlorophene 5.69 µM 0.0467762472939056 0.482641279706261 no 1598 0.481345780109884 2248 62616
SGTC_332 4112-0506 40.9 µM 0.046747136629953 0.482653014909504 no 1599 0.481357380894147 2315 2790355
SGTC_1993 st073995 70.8 µM 0.0455659903691415 0.48312917571328 no 1600 0.481828088378159 2234 3098394
SGTC_1202 1988-0068 29.6 µM 0.0450878604683613 0.483321933250739 no 1601 0.482018638762958 2275 2850480
SGTC_1912 st060209 90.8 µM 0.0447031037949416 0.483477050308235 no 1602 0.482171979851329 2280 688787
SGTC_2942 9052777 62.25 µM 0.0445974322812605 0.483519652878126 no 1603 0.482214094683977 2301 6469503
SGTC_1906 st060206 94.7 µM 0.0443920481604909 0.483602456160534 no 1604 0.482295950025352 2314 5133468
SGTC_633 0437-0093 97.7 µM 0.0443869494556091 0.483604511778804 no 1605 0.482297982111279 2314 2831118
SGTC_1150 3909-7983 10.9 µM 0.0443707126446998 0.483611057892125 no 1606 0.482304453286084 2299 23965914
SGTC_772 k072-0172 35.3 µM 0.0431267771156622 0.484112582119164 no 1607 0.482800237050352 2267 5861980
SGTC_2673 kobusone 100 µM 0.0418846646762002 0.484613396402577 no 1608 0.483295320742753 2337 6710676 An epoxy ketone and protein crosslinker.
SGTC_3279 9140807 49.47 µM 0.0417317950485512 0.484675034458891 no 1609 0.483356253624127 2308 45595718
SGTC_2424 5537928 59.2 µM 0.0412425945999949 0.484872285805401 no 1610 0.483551248481137 2298 5382802
SGTC_1761 st044296 37 µM 0.0406702405297621 0.485103070361112 no 1611 0.483779393287476 2341 1826700
SGTC_2635 hydroquinidine 100 µM 0.0406122597301521 0.485126449653459 no 1612 0.483802505184915 2314 442912 An experimental heart treatment.
SGTC_3127 9126946 49.47 µM 0.0401016872535691 0.485332327301605 no 1613 0.484006028325748 2214 27243249
SGTC_1358 1509-0022 2.48 µM 0.0395547486250787 0.485552873174211 no 1614 0.484224052273856 2306 3258434
SGTC_345 1362-0200 395 µM 0.0392170414990987 0.485689051381785 no 1615 0.484358673468181 2292 1419823
SGTC_1635 st007035 42.4 µM 0.0384608245907204 0.485993996973046 no 1616 0.484660132902983 2342 3716403
SGTC_1982 st072467 71.9 µM 0.0384115114522755 0.486013882855746 no 1617 0.484679791472336 2258 3163533
SGTC_3333 9141820 12.094 µM 0.0364698816112483 0.486796886389871 no 1618 0.485453846859481 2281 1939433
SGTC_1774 st048371 48.465 µM 0.0361272976665145 0.486935046021565 no 1619 0.485590428070454 2323 4242727
SGTC_2194 5927483 104.545 µM 0.0360211723910454 0.486977845278343 no 1620 0.485632738390603 2331 760979
SGTC_195 4234-0266 16.654 µM 0.0357037143493491 0.487105873808747 no 1621 0.485759304409765 2308 2303354
SGTC_1868 st057644 42.7 µM 0.035514065466815 0.487182358465282 no 1622 0.485834915415012 2335 688665
SGTC_200 k038-0079 37.545 µM 0.0350652239003814 0.487363376396051 no 1623 0.486013865828108 2285 3436683
SGTC_1505 k297-0037 20.6 µM 0.0348215809808902 0.487461638746995 no 1624 0.486111005965602 2316 4089396
SGTC_635 k038-0028 24.7 µM 0.0339035256491054 0.487831901627198 no 1625 0.48647704087227 2303 4035102
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.0334114845389624 0.488030352128216 no 1626 0.486673225719538 2321 5393153
SGTC_277 nystatin 15.5 µM 0.0330140052927997 0.488190666012276 no 1627 0.486831709560575 2343 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_160 3453-0671 289.699 µM 0.0328496271161622 0.488256964634096 no 1628 0.486897251415281 2341 5322268
SGTC_253 dyclonine 31.25 µM 0.03280577233313 0.488274652631135 no 1629 0.486914737517872 2348 3180 An oral anasthetic.
SGTC_3296 9122258 64.045 µM 0.0324967543146412 0.488399289854343 no 1630 0.487037952172974 2321 4730474
SGTC_11 0438-0307 1.3 µM 0.0318605105037009 0.488655911654483 no 1631 0.487291645346396 2358 4011476
SGTC_526 4469-0568 170 µM 0.0313058266485061 0.488879640997641 no 1632 0.487512821846745 2346 2901964
SGTC_2973 9094665 17.96 µM 0.0310452850193253 0.488984730553372 no 1633 0.48761671241945 2339 25237061 YIL048W NEO1
SGTC_2552 juarezic acid 87.02 µM 0.0305856142458033 0.489170140778264 no 1634 0.487800007476042 2353 1549512
SGTC_2399 5884133 200 µM 0.030550700315748 0.489184223561393 no 1635 0.487813929612888 2330 722445
SGTC_3018 9082602 49.47 µM 0.0297747399688528 0.489497216159211 no 1636 0.488123352208658 2325 17332089
SGTC_844 0330-0132 15.3 µM 0.0287105844620176 0.489926466092915 no 1637 0.48854770733435 2346 2828079
SGTC_2204 7233102 200 µM 0.0280852914865401 0.490178696891611 no 1638 0.488797062570194 2347 2172480
SGTC_2886 9058944 51.95 µM 0.0239660553413872 0.491840408614134 no 1639 0.490439842419473 2371 4949929
SGTC_1973 st070275 50.2 µM 0.0239016492966822 0.491866391397589 no 1640 0.490465529355646 2365 17118334
SGTC_3038 9091290 49.47 µM 0.0227753524001215 0.49232076926686 no 1641 0.4909147344298 2357 25236843
SGTC_2166 5933061 31.504 µM 0.0225012460990974 0.492431352507149 no 1642 0.491024059004654 2345 2877375
SGTC_2646 retinol 96.75 µM 0.0222305121007227 0.492540575823816 no 1643 0.491132039232028 2348 445354 A vitamin A analog and teratogen.
SGTC_2172 5754775 163.918 µM 0.0221568587137551 0.49257029020601 no 1644 0.491161415446517 2352 2263357
SGTC_2475 5812728 15.03 µM 0.0216519896564901 0.492773973347416 no 1645 0.491362780743676 2366 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1653 st012112 65 µM 0.0212877042455705 0.492920940938542 no 1646 0.4915080761043 2350 720429
SGTC_1303 1160-0052 261 µM 0.021084647167732 0.493002862863236 no 1647 0.491589065979489 2363 3562476
SGTC_230 MPP+ 141.667 µM 0.0210354762979583 0.493022700543226 no 1648 0.491608677968706 2313 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1796 st049173 110.4 µM 0.0204581570715887 0.493255617653214 no 1649 0.491838945451801 2365 94134
SGTC_609 0986-0026 86.3 µM 0.0198737755325456 0.493491386366146 no 1650 0.492072032553154 2370 2848610
SGTC_754 3474-0146 171 µM 0.0192004406636653 0.493763046111043 no 1651 0.492340603034767 2376 24762078
SGTC_1481 3346-2004 36 µM 0.0178372607109807 0.494313035439583 no 1652 0.492884339866918 2374 2770522
SGTC_619 1652-1634 108 µM 0.0174466795603521 0.49447062156227 no 1653 0.493040134954193 2355 5400454
SGTC_2260 7964312 200 µM 0.01697174501244 0.494662242553064 no 1654 0.493229578369425 2377 231951
SGTC_2366 9070441 60.58 µM 0.0164652651623675 0.494866592426353 no 1655 0.493431606357398 2379 6837235
SGTC_2939 9044578 71.43 µM 0.0161334544372576 0.495000469126897 no 1656 0.493563962101542 2368 2653634
SGTC_1454 4239-0054 42.6 µM 0.0159503416424888 0.495074350455193 no 1657 0.493637004138341 2369 1340767
SGTC_1685 st024049 53.0905 µM 0.0155432962919672 0.495238583442595 no 1658 0.49379937160583 2345 1941139
SGTC_2151 5563267 85.4165 µM 0.0150778994109106 0.495426360853255 no 1659 0.493985016337001 2360 5310824
SGTC_3179 9107801 49.47 µM 0.0149481261327346 0.495478721700652 no 1660 0.494036782550359 2379 4818259
SGTC_565 1418-0001 44.5 µM 0.0144518198310563 0.495678971791615 no 1661 0.494234758724683 2373 2862145
SGTC_862 0452-0056 10.2 µM 0.013853546989962 0.495920364871817 no 1662 0.494473411150601 2375 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_923 1900-2434 73.3 µM 0.0130048885877169 0.496262786877311 no 1663 0.494811946330964 2380 5910570
SGTC_1493 4348-0038 111 µM 0.0124636854325646 0.496481156368532 no 1664 0.495027837643806 2380 800424
SGTC_3217 9129673 49.47 µM 0.0123711338244933 0.496518500026802 no 1665 0.495064757546884 2386 17248312
SGTC_3341 9147222 25.867 µM 0.0120341328137285 0.496654476856141 no 1666 0.495199191488714 2366 1939759
SGTC_527 4476-4215 268 µM 0.0119329060322956 0.496695321014371 no 1667 0.495239572232182 2290 4418754
SGTC_477 mead ethanolamide 10 µM 0.0116539733215228 0.496807868204214 no 1668 0.495350842545239 2386 16061185
SGTC_2833 9001315 45.46 µM 0.0114345491280038 0.496896404346936 no 1669 0.495438374300329 2355 2989378
SGTC_113 0099-0221 2.5 µM 0.0105218306600799 0.497264681519883 no 1670 0.495802474333202 2385 89219
SGTC_2090 5301565 104.445 µM 0.0104162763551577 0.497307272291383 no 1671 0.495844582100703 2383 2056344
SGTC_1398 3558-0053 112 µM 0.010017566413987 0.497468150550337 no 1672 0.49600363605112 2380 4532369
SGTC_496 calpeptin 138 µM 0.00790677522568295 0.498319854665674 no 1673 0.496845685927304 2354 73364 A calpain inhibitor.
SGTC_727 3032-0951 202 µM 0.00731802854338927 0.498557415448256 no 1674 0.49708055506265 2380 3652836
SGTC_2237 6667747 47.222 µM 0.00686692501517802 0.498739437218919 no 1675 0.497260514805031 2362 729940 YDL015C TSC13
SGTC_2867 9039098 71.43 µM 0.00554374144564129 0.49927334755324 no 1676 0.497788378474045 2400 6463460
SGTC_2483 5729050 27.16 µM 0.0043024614368148 0.49977421064512 no 1677 0.498283571518577 2400 2865180
SGTC_2674 ligustilide 100 µM 0.00414845181831818 0.499836354386991 no 1678 0.498345011918428 2395 5319022 A signalling regulator.
SGTC_456 gingerol 170 µM 0.0033373324570203 0.499836354386991 no 1679 0.498668599450615 2391 442793 A herb.
SGTC_919 tnp00227 403.569 nM 0.00324300098669831 0.499798291110901 no 1680 0.498706232058794 2395 1269246 A methoxyflavone. YNL221C POP1
SGTC_1151 3909-8316 15.3 µM 0.00319495930917639 0.499778906025896 no 1681 0.498725397815881 2382 800431
SGTC_3156 9099931 49.47 µM 0.00302717401614213 0.499711203728126 no 1682 0.498792334139293 2400 18111053
SGTC_2706 st078239 82.5 µM 0.00264619554717872 0.499557476833551 no 1683 0.498944321946059 2398 15434492
SGTC_1760 st045453 10.4495 µM 0.00196877202369115 0.499284132916083 no 1684 0.499214574106672 2396 3323419 YIL048W NEO1
SGTC_2444 5485484 36.41 µM 0.0015845932740203 0.499129114932194 no 1685 0.499367839010306 2398 6790631
SGTC_1498 4478-3555 97.6 µM 0.00131955095516635 0.499022169149681 no 1686 0.49947357548561 2402 3437919
SGTC_2776 terbinafine 19.92 µM 0.00116872419292911 0.498961309895217 no 1687 0.499533746611456 2400 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2468 5987765 72.9 µM 0.000909918436956875 0.498856880704324 no 1688 0.499636995113873 2403 26772094
SGTC_1102 cgs 12066b 26.1 µM 0.000644890169544557 0.498749940785613 no 1689 0.499742726062986 2400 6438352 A 5-HT1B full agonist.
SGTC_1334 1486-0610 236 µM 0.000371346493257815 0.498639564961166 no 1690 0.499851854186565 2403 3742339
SGTC_246 cycloheximide 667 µM 0.000247306402979189 0.498589514387282 no 1691 0.499901339020643 2384 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1364 1653-0028 37.6 µM 6.09398044976595e-05 0.498514314909613 no 1692 0.499975688535442 2405 5718652
SGTC_2242 6630449 61.2675 µM 0 0.498489725528282 no 1693 0.5 2404 691249 YDR170C SEC7
SGTC_168 3970-0862 530.542 µM -0.00037264690036868 0.498339361591397 no 1694 0.499851335399223 2403 3135186
SGTC_258 haloperidol 50.781 µM -0.00225151140313132 0.497581239194956 no 1695 0.499101777665379 2411 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1956 st077085 54 µM -0.00240851682530917 0.497517887817107 no 1696 0.499039141734308 2413 24208685
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.00361303554721217 0.497031869091373 no 1697 0.498558610495614 2425 61125 An anti-inflammatory.
SGTC_3228 9131799 49.47 µM -0.00362000873244799 0.497029055449766 no 1698 0.498555828615387 2419 17015818
SGTC_714 4296-0578 26.1 µM -0.00441833389042464 0.496706936683678 no 1699 0.498237345537175 2416 1589775
SGTC_871 0574-0004 149 µM -0.0048474936506733 0.496533774516152 no 1700 0.498066137402485 2424 9551173
SGTC_2380 9035439 200 µM -0.00498283581415746 0.49647916528414 no 1701 0.4980121443434 2450 6462575
SGTC_536 3852-0578 10.6 µM -0.00501091815804434 0.496467834342774 no 1702 0.498000941248956 2416 2869208
SGTC_135 0933-0004 26.348 µM -0.0052150936939275 0.496385451667999 no 1703 0.497919488059926 2419 21230617 YGL099W LSG1
SGTC_1600 coumarin 106 71.1 µM -0.00553992680105197 0.496254385255232 no 1704 0.497789900273688 2450 100336 A hepatotoxic, DNA x-linker.
SGTC_1935 st074532 41.6 µM -0.0059596545081334 0.496085030566467 no 1705 0.497622455914192 2438 2829742
SGTC_2965 9082772 38.63 µM -0.00600743128200164 0.496065753301709 no 1706 0.497603396080277 2419 16459634
SGTC_591 4299-0174 154 µM -0.00613135765196839 0.496015750775381 no 1707 0.497553957522279 2424 5509088
SGTC_2252 omeprazole 400 µM -0.00630603839746119 0.49594526968744 no 1708 0.49748427133489 2446 4594 A proton pump inhibitor.
SGTC_17 0960-0276 49.807 µM -0.00634251932530694 0.495930550190461 no 1709 0.497469717841393 2418 6821114
SGTC_1226 3909-7979 35.4 µM -0.00672776529056901 0.495775109671869 no 1710 0.497316030220333 2427 6615510
SGTC_1922 5578187 25 µM -0.00688773605354428 0.495710564242431 no 1711 0.497252212598268 2424 1350412
SGTC_1738 st035555 74 µM -0.00762933364721618 0.495411343964152 no 1712 0.496956365763532 2426 5331140
SGTC_519 k048-0011 62.8 µM -0.00765289755782767 0.495401836423636 no 1713 0.496946965397729 2448 6836379
SGTC_1129 3453-1384 223 µM -0.00844827749533959 0.495080918975212 no 1714 0.496629665002633 2448 1084452
SGTC_1675 st018485 24.5 µM -0.00890668597455449 0.49489596316608 no 1715 0.496446793365308 2451 3323024
SGTC_115 0527-0192 112.043 µM -0.0116385882717759 0.493793736292277 no 1716 0.495356979875834 2452 4233931
SGTC_2496 diffractaic acid 79.83 µM -0.0120405996248265 0.493631542591741 no 1717 0.495196611791251 2417 94870 An apoptosis inducer which activates caspases.
SGTC_3009 9080819 71.4286 µM -0.0126220507430755 0.493396954796609 no 1718 0.494964663995307 2437 17027216
SGTC_139 0099-0334 718.624 µM -0.0133144796100769 0.493117595758346 no 1719 0.494688448077014 2435 97690
SGTC_490 phenamil 164 µM -0.013368629467809 0.49309574924733 no 1720 0.49466684733181 2430 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_3110 9122132 49.47 µM -0.0160811710827022 0.492001414683037 no 1721 0.493584817436646 2514 918317
SGTC_417 st075190 100 µM -0.0161115567802839 0.491989156350924 no 1722 0.49357269686744 2430 222757
SGTC_3120 9124077 49.47 µM -0.016437210758448 0.491857780064382 no 1723 0.493442796930843 2426 18774327 YGL155W CDC43
SGTC_2622 2-methoxyxanthone 59.94 µM -0.0166095730836124 0.491788245504305 no 1724 0.493374043698102 2453 71034 A hepatoprotective.
SGTC_196 k015-0023 18.111 µM -0.0169854168301074 0.491636623159338 no 1725 0.493224124889408 2433 5211998
SGTC_1119 parthenolide 318.541 nM -0.0171236587563019 0.491580854102633 no 1726 0.493168982360054 2498 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.0172347666392894 0.49153603148251 no 1727 0.493124663268194 2416 91467 include heat shock
SGTC_722 3534-0461 190 µM -0.018283148599188 0.491113103498245 no 1728 0.492706485345325 2449 658262
SGTC_3034 9090421 49.47 µM -0.0195081972139339 0.490618919073784 no 1729 0.492217848928642 2425 17173761
SGTC_665 3914-0008 307 µM -0.0204761479631128 0.490228458035475 no 1730 0.491831769627659 2456 1069549
SGTC_3211 9128781 49.47 µM -0.0212628439018782 0.489911120140869 no 1731 0.491517991702165 2495 17194361
SGTC_2388 9080168 200 µM -0.0216410884423379 0.4897585458851 no 1732 0.491367128680128 2448 15943073
SGTC_1070 indatraline 8.81 µM -0.0216471429821572 0.4897561036494 no 1733 0.49136471383391 2462 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_3181 9108277 49.47 µM -0.0218787005929212 0.48966269993413 no 1734 0.491272357586527 2440 17097298
SGTC_2588 indole-3-carbinol 100 µM -0.0220753347392749 0.489583383790131 no 1735 0.491193930853826 2463 3712 Induces cell cycle arrest.
SGTC_1674 st016616 23.6 µM -0.0226896830484957 0.489335577317143 no 1736 0.490948902726616 2442 625830
SGTC_214 4373-3496 70 µM -0.0251178786093091 0.488356169950954 no 1737 0.489980469806501 2473 3779166
SGTC_3177 9107506 49.47 µM -0.0253479955361467 0.488263356341956 no 1738 0.489888695656155 2456 8897194
SGTC_1829 berberine 14.4 µM -0.0271241779567103 0.487546986215137 no 1739 0.489180345316115 2485 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1306 1185-0270 9.02 µM -0.0277773278187377 0.48728356770844 no 1740 0.488919874381966 2468 1548076
SGTC_894 0960-0238 55.9 µM -0.028534558965974 0.486978179666687 no 1741 0.488617902587383 2439 6741907 YDL195W SEC31
SGTC_2634 4'-methoxyflavone 100 µM -0.0288074520885886 0.486868124914767 no 1742 0.488509078720326 2470 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_691 1548-0686 185 µM -0.0289726625938311 0.486801497846574 no 1743 0.488443196764138 2471 46495133
SGTC_2826 7992541 19.48 µM -0.0296636919310944 0.486522819469058 no 1744 0.488167634406012 2449 2985066
SGTC_2429 5902844 64.44 µM -0.0298584700178268 0.486444270526595 no 1745 0.488089963597029 2491 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2917 7979103 53.79 µM -0.0309156958507149 0.486017928065458 no 1746 0.487668386213887 2470 2980565
SGTC_1320 1313-0481 95.3 µM -0.0309844015721223 0.485990221981929 no 1747 0.487640989721486 2463 6813365 YLR208W SEC13
SGTC_886 0866-0150 153 µM -0.0311061222923126 0.485941137379388 no 1748 0.487592453575238 2468 271463
SGTC_1349 flufenamic acid 69 µM -0.0313895987514423 0.48582682464242 no 1749 0.487479418029625 2463 3371 A non-steroidal anti-inflammatory.
SGTC_932 2857-0803 154 µM -0.0319286432365001 0.485609456549071 no 1750 0.487264478140234 2625 674898
SGTC_1872 amphotericin b 148 nM -0.0325070640154685 0.485376214839193 no 1751 0.487033841369263 2467 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1372 2752-0194 270 µM -0.0326637073642926 0.485313051018292 no 1752 0.486971382882781 2468 823334
SGTC_2043 5101342 149 µM -0.0329156349879677 0.485211466174473 no 1753 0.486870932317222 2481 678451
SGTC_1125 tnp00248 1.32998 µM -0.0332590163395713 0.485073005966085 no 1754 0.486734017943904 2479 24207736
SGTC_2806 7952793 58.44 µM -0.0335313246018619 0.484963205537232 no 1755 0.486625443225286 2513 2972490
SGTC_326 k292-0812 17.5 µM -0.0336139069094976 0.484929906835724 no 1756 0.486592516212752 2461 3579357
SGTC_47 0149-0135 24.25 µM -0.0343891179464765 0.484617332678505 no 1757 0.4862834304807 2453 5239155
SGTC_285 1486-1325 46 µM -0.034515614647218 0.484566328621179 no 1758 0.486232995539629 2482 22310230
SGTC_245 methotrexate 289.6 µM -0.0352848436092525 0.484256177397617 no 1759 0.485926304426681 2490 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_940 3232-1287 54.8 µM -0.0354401295651239 0.484193567632018 no 1760 0.485864393015777 2468 1585493 YIL048W NEO1
SGTC_3244 9134489 49.47 µM -0.0357214566954116 0.484080140301858 no 1761 0.485752230750039 2508 16584271
SGTC_2393 9031399 185.94 µM -0.0360782192506007 0.483936300272878 no 1762 0.485609994769751 2484 1526623 YDL150W RPC53
SGTC_1521 st012942 49.4 µM -0.036634816051352 0.483711894973432 no 1763 0.485388091479613 2581 24207259
SGTC_1335 1486-0900 202 µM -0.0374503252464515 0.483383112293079 no 1764 0.485062973522803 2470 X1335
SGTC_1731 st035964 63 µM -0.0381710157195843 0.483092566357901 no 1765 0.484775665076423 2529 6739575
SGTC_425 3825-7017 13.1 µM -0.0384673587085647 0.48297309845448 no 1766 0.484657528094712 2653 3397440
SGTC_88 0180-0332 8.668 µM -0.0385720180225396 0.482930906395988 no 1767 0.484615806033729 2458 3101745
SGTC_2695 st077686 51.995 µM -0.0386851236625275 0.482885309524554 no 1768 0.484570717064487 2493 2876092
SGTC_604 1000-0114 314 µM -0.0389442994629391 0.482780827466324 no 1769 0.484467398738013 2484 1572745
SGTC_882 0843-0131 351 µM -0.0396611480997055 0.48249184902372 no 1770 0.484181638307181 2461 5425421
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.0408287717816205 0.482021172383691 no 1771 0.483716200956333 2476 6312947
SGTC_2779 methotrexate 400 µM -0.0409071748314034 0.481989568498939 no 1772 0.483684948774331 2471 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_931 2812-0076 566 µM -0.0409282446759302 0.481981075367257 no 1773 0.483676550156183 2464 3450959
SGTC_1947 st076332 61.6 µM -0.0429184860479896 0.481178858065484 no 1774 0.482883256296058 2471 24208416
SGTC_1573 oleylamine 1.06 µM -0.0446307716705617 0.480488738751164 no 1775 0.482200807422168 2486 5356789 An amine of the fatty acid oleic acid.
SGTC_1719 st032227 49.2 µM -0.0454345374044222 0.480164809183464 no 1776 0.481880476266912 2503 3125804
SGTC_478 N-arachidonylglycine 10 µM -0.0463885496107911 0.479780345065635 no 1777 0.481500281388063 2485 5283389
SGTC_1503 4585-0012 61.3 µM -0.0466472406268074 0.479676096572646 no 1778 0.48139719020512 2591 2922052
SGTC_2741 miltefosine 3.04 µM -0.0468272304802575 0.479603564255069 no 1779 0.481325463024749 2506 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2117 5521686 200 µM -0.0470176428210343 0.479526832618405 no 1780 0.481249583070433 2498 803312
SGTC_1783 st039459 87.517 µM -0.0477783200832238 0.479220305403156 no 1781 0.480946457443679 2589 729761
SGTC_2863 9028737 58.44 µM -0.0480751544270744 0.479100694523167 no 1782 0.480828173599462 2526 6460917
SGTC_640 3381-0960 37.1 µM -0.0494721375510327 0.47853779865318 no 1783 0.480271520507703 2533 1745025
SGTC_1747 st037496 66.6 µM -0.0499728700488452 0.478336045480474 no 1784 0.480072003932885 2502 723305
SGTC_2993 9054257 71.4286 µM -0.0503938210391637 0.47816644185261 no 1785 0.479904280114293 2491 6470217 YGL055W OLE1
SGTC_3123 9126162 49.47 µM -0.0509423310993065 0.477945449863243 no 1786 0.479685736970808 2501 25239884
SGTC_62 0180-0423 3.232 µM -0.0524730945547206 0.477328748924302 no 1787 0.479075866613219 2532 30102 YGL099W LSG1
SGTC_3099 9120367 49.47 µM -0.0525528287266511 0.477296627775199 no 1788 0.479044101109514 2508 24824940
SGTC_1620 st003704 16.5 µM -0.0530068782555856 0.47711371538522 no 1789 0.478863213682347 2499 2834414
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0532223139560188 0.477026929491562 no 1790 0.478777388421737 2531 23847180
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.0534640953615276 0.476929531819229 no 1791 0.478681068732947 2482 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2932 9016711 44.54 µM -0.054396597523146 0.476553901582177 no 1792 0.478309594813195 2506 7117328
SGTC_2996 9066192 71.4286 µM -0.0565677999074276 0.475679379792957 no 1793 0.477444742703373 2535 6472854
SGTC_274 sirtinol 40.1 µM -0.0567105112465818 0.475621902255232 no 1794 0.47738790036444 2527 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2136 5328288 199.296 µM -0.0570943889073838 0.475467296579837 no 1795 0.477235003068683 2515 262395
SGTC_1820 st053765 18.6 µM -0.0572328593366484 0.475411528899378 no 1796 0.477179851542328 2552 3690829
SGTC_364 0083-0097 67.7 µM -0.0579015426948004 0.475142229681099 no 1797 0.47691352714654 2586 5207356
SGTC_713 1488-1073 324 µM -0.0584530163468556 0.474920142931664 no 1798 0.476693892994086 2504 3312542
SGTC_145 3737-0113 38.366 µM -0.0598477679116025 0.474358490393511 no 1799 0.476138440220073 2574 6849351
SGTC_1113 artemisinin 1.17947 µM -0.0600057818117735 0.474294862965465 no 1800 0.476075514885281 2511 2240 An anti-malaria and mitochondrial poison.
SGTC_3146 9095609 49.47 µM -0.0601653607154566 0.474230606023195 no 1801 0.476011966930032 2565 17173999
SGTC_1810 st050138 53 µM -0.0604715851365454 0.474107301847967 no 1802 0.475890023098772 2511 3444541
SGTC_2190 6049624 200 µM -0.0612846684245019 0.473779918197994 no 1803 0.475566250337476 2500 2265554
SGTC_2270 7924575 90.91 µM -0.0625217325079732 0.473281854980346 no 1804 0.47507367787744 2571 1262135
SGTC_1459 k035-0031 35.7 µM -0.0629523288355984 0.473108499272873 no 1805 0.474902232528975 2498 3877128 YMR208W ERG12
SGTC_795 0685-0265 78 µM -0.0641795616048338 0.472614450179815 no 1806 0.474413625657514 2519 302754
SGTC_3071 9117417 49.47 µM -0.0643807400997558 0.472533465424619 no 1807 0.47433353269074 2566 45595590 YGL055W OLE1
SGTC_2662 daunorubicin 22.37 µM -0.0654780495067483 0.472091761676049 no 1808 0.473896691390193 2483 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3342 9147791 14.508 µM -0.0655273717081309 0.472071908641797 no 1809 0.473877056845953 2517 1838168
SGTC_1311 1190-0148 100 µM -0.066298395098868 0.471761567519656 no 1810 0.473570130470543 2580 1961333
SGTC_71 0417-1750 47.813 µM -0.0667076165500772 0.471596860605104 no 1811 0.473407235345356 2518 6811472
SGTC_428 3448-4153 16.5 µM -0.0667992503179913 0.471559979734991 no 1812 0.47337076011882 2499 3834874
SGTC_420 mitomycin C 81.9 mM -0.0673435533480226 0.471340913028474 no 1813 0.473154102502981 2517 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_6 0844-0013 19.835 µM -0.0673586904444662 0.471334820895242 no 1814 0.473148077356272 2547 1584900
SGTC_904 1141-0088 396 µM -0.0688976597907271 0.470715476713222 no 1815 0.472535540655576 2553 1378119
SGTC_2325 6158266 200 µM -0.0690272758321078 0.470663317132123 no 1816 0.472483954150566 2590 3623240
SGTC_1079 idarubicin 2.36 µM -0.0704507320145385 0.470090528764298 no 1817 0.47191745660767 2521 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1759 st043059 70 µM -0.0709064388691116 0.469907168675469 no 1818 0.471736109400212 2555 669426
SGTC_279 1273-0055 2.93 µM -0.0720352158937803 0.469453016857969 no 1819 0.471286941203302 2536 2847562
SGTC_1636 st007707 68.9 µM -0.0720564781369186 0.469444462592765 no 1820 0.471278480781406 2574 403051
SGTC_1088 bifonazole 369 nM -0.0736395822242629 0.468807585101222 no 1821 0.470648587282266 2509 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2303 7774051 200 µM -0.0743064701320656 0.468539322119164 no 1822 0.470383264422915 2617 2953184
SGTC_1843 st055809 45.5 µM -0.0743078952903937 0.468538748848833 no 1823 0.470382697434494 2650 16413835
SGTC_483 fpl-64176 144 µM -0.0749594035693319 0.468276686314065 no 1824 0.470123506118092 2550 3423
SGTC_404 fumagillin 50 µM -0.0753351954188829 0.468125534133932 no 1825 0.469974009570264 2568 12015870 A methionine aminopeptidase binder.
SGTC_1687 st020778 55.3625 µM -0.0759698845715175 0.46787025791136 no 1826 0.46972152878387 2551 4259299
SGTC_324 1315-0088 19.6 µM -0.0760485231904609 0.467838629850588 no 1827 0.469690247008203 2524 6787421
SGTC_10 0279-0212 42.575 µM -0.0764108900782507 0.467692890319879 no 1828 0.469546102953699 2558 39851 YBR002C RER2
SGTC_2294 7971431 200 µM -0.0777572767061743 0.467151428173355 no 1829 0.469010565877089 2621 5741572
SGTC_1419 3993-2473 62.6 µM -0.0800546657116294 0.466227652282533 no 1830 0.468096889245444 2562 704026
SGTC_344 k064-0035 6.43 µM -0.0820394181531587 0.465429733263888 no 1831 0.467307683966597 2554 5088750
SGTC_2417 cerulenin 830 nM -0.0828880683526877 0.465088597357042 no 1832 0.466970270733805 2542 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2137 5261020 140 µM -0.0831590310800681 0.464979682588462 no 1833 0.46686254416107 2558 763655
SGTC_3283 9109332 35.8195 µM -0.0831953203106978 0.464965096157101 no 1834 0.466848116846343 2523 17027281
SGTC_1331 1472-0049 76.2 µM -0.0833890265692961 0.464887236856128 no 1835 0.466771106825606 2554 24051409
SGTC_300 r073-0011 5.04 µM -0.0837832219592067 0.464728796065714 no 1836 0.466614394024139 2551 2735780
SGTC_629 3448-6466 76.7 µM -0.0837852024095113 0.46472800006819 no 1837 0.466613606707036 2569 573744
SGTC_873 0591-4978 488 µM -0.0841986518639749 0.464561826440498 no 1838 0.466449245020284 2664 3305145
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.0842386720465882 0.464545741854117 no 1839 0.466433335797865 2641 521171
SGTC_3225 9130819 49.47 µM -0.0845576227032138 0.464417553872719 no 1840 0.466306545268668 2564 4547121
SGTC_2004 4023728 41.89 µM -0.0866043289071075 0.463595060118374 no 1841 0.465493012430823 2586 360084 YDR527W RBA50
SGTC_2553 4-methylesculetin 85.09 µM -0.0871706161773627 0.463367518027287 no 1842 0.465267947659987 2559 5319502
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.0886349450656135 0.462779186080786 no 1843 0.464686017611761 2558 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1390 3413-2614 145 µM -0.0891828994893346 0.46255905210345 no 1844 0.464468277724812 2587 3421432
SGTC_1030 k029-0042 36.7 µM -0.0903421746674591 0.46209336537538 no 1845 0.464007653307902 2621 6080581
SGTC_2972 9093619 59.92 µM -0.090801314807707 0.461908940777763 no 1846 0.463825232651779 2574 25236256
SGTC_2415 st077333 57.7 µM -0.0918098073028332 0.461503884498215 no 1847 0.463424575937007 2553 2766255
SGTC_1122 capsaicin 818.572 nM -0.0918311222187738 0.461495323891629 no 1848 0.463416108286549 2694 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1723 st034307 2.5525 µM -0.0943164762619668 0.460497266529561 no 1849 0.462428881046424 2634 867466
SGTC_1928 4'-methoxychalcone 40.3 µM -0.0943701199951284 0.460475727239685 no 1850 0.46240757532197 2739 641818
SGTC_2285 7945142 200 µM -0.0946038492158054 0.460381880512561 no 1851 0.462314746159783 2655 2970608
SGTC_36 0335-0881 14.2 µM -0.0951119332914571 0.460177882713266 no 1852 0.462112959826107 2564 23828853
SGTC_1165 k072-0275 30.3 µM -0.0976364152451745 0.45916444952477 no 1853 0.461110503727006 2585 6153523 YGL055W OLE1
SGTC_1701 st028638 40.4 µM -0.0985394637494702 0.458801991975381 no 1854 0.460751968442505 2580 3490878
SGTC_2203 7227154 166.4 µM -0.0989302710460328 0.458645143830455 no 1855 0.460596816988213 2581 896304
SGTC_1597 7-benzyloxygramine 47.5 µM -0.0993940236595761 0.458459027878684 no 1856 0.460412713848632 2571 260807
SGTC_2855 9016525 58.44 µM -0.0998813575751914 0.458263457952402 no 1857 0.460219258415004 2580 43811474
SGTC_2159 5658611 73.75 µM -0.101333852352868 0.457680623490572 no 1858 0.459642722101106 2579 793844
SGTC_1892 st058411 7.36 µM -0.10150375616002 0.457612453059979 no 1859 0.459575287988254 2679 3934738
SGTC_2323 6148992 148.28 µM -0.101545924344741 0.457595534130659 no 1860 0.459558551791564 2646 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_780 0109-0199 192 µM -0.102437660333372 0.457237765414247 no 1861 0.45920464613064 2738 610414
SGTC_1825 st052143 62.6 µM -0.104203378845564 0.456529453274526 no 1862 0.458503976320627 2671 674173
SGTC_264 promethazine 12.5 mM -0.105292856520203 0.456092481659953 no 1863 0.458071715569558 2580 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1989 st071868 50.2 µM -0.106203285649437 0.455727364183337 no 1864 0.457710532060571 2620 16414057
SGTC_2978 9011784 42.97 µM -0.106500712604952 0.455608092497835 no 1865 0.457592545024284 2755 2994934
SGTC_321 4534-3890 65.3 µM -0.106680830950919 0.455535864880212 no 1866 0.457521095247407 2679 699746
SGTC_138 0850-0259 40.9225 µM -0.10682180255787 0.455479336164989 no 1867 0.45746517525036 2593 6813004
SGTC_25 0118-0223 35.662 µM -0.107279771981087 0.455295699573654 no 1868 0.457283515770832 2627 5333628
SGTC_2557 derrustone 83.84 µM -0.109013755960617 0.454600493505709 no 1869 0.456595789841544 2709 629853 An antioxidant.
SGTC_1143 3454-2408 5.08 µM -0.11227169794122 0.453294664775789 no 1870 0.45530399083551 2579 X1143
SGTC_2572 astragaloside iv 100 µM -0.112525495139797 0.453192960321927 no 1871 0.455203377957732 2782 45006101 An anti-inflammatory agent.
SGTC_1966 st070145 16.1 µM -0.112782161765043 0.453090109121745 no 1872 0.455101630474789 2585 3748532
SGTC_2038 4100038 30.985 µM -0.113023477791366 0.452993412068627 no 1873 0.455005970944497 2697 3596803
SGTC_2995 9067767 71.4286 µM -0.113539094098236 0.452786810284177 no 1874 0.454801585421595 2685 11673567
SGTC_1462 k081-0014 26.5 µM -0.115333961998786 0.452067726490467 no 1875 0.454090210092137 2612 3270634
SGTC_2354 9060492 162 µM -0.11780695661564 0.45107722057462 no 1876 0.453110308676617 2715 6471895
SGTC_281 1672-3440 14.9 µM -0.118563123655128 0.45077441430533 no 1877 0.452810741138531 2699 6833000
SGTC_689 0833-0039 98 µM -0.11989942465513 0.450239364177507 no 1878 0.452281410123638 2689 5374726
SGTC_359 0081-0058 15.9 µM -0.119918682926298 0.450231653893497 no 1879 0.4522737822203 2910 3494159
SGTC_3125 9127534 49.47 µM -0.120563915946211 0.44997333785134 no 1880 0.452018225600913 2596 1639235
SGTC_2066 5222451 176 µM -0.121197341551874 0.449719769468309 no 1881 0.451767364865504 2618 2281147
SGTC_2726 cimetidine 79.27 µM -0.121283969050467 0.449685092964492 no 1882 0.451733058561787 2619 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_3219 9131112 49.47 µM -0.124524416184532 0.44838823835184 no 1883 0.450450034756024 2633 17612988 YMR079W SEC14
SGTC_611 3453-1652 23.7 µM -0.125207195053287 0.448115054279459 no 1884 0.450179760621902 2628 1560575
SGTC_854 0422-0053 192 µM -0.125520056626841 0.447989884630283 no 1885 0.450055923857886 2634 3596728
SGTC_2330 7979373 200 µM -0.125699815395251 0.447917969089109 no 1886 0.449984774000935 2664 1863007
SGTC_1480 1070-0044 41.2 µM -0.125745886353765 0.447899537897016 no 1887 0.449966539031767 2720 3124987
SGTC_3292 9120825 59.784 µM -0.126017323062319 0.447790948950569 no 1888 0.449859106034812 2637 24824900
SGTC_2795 7780010 54.55 µM -0.126396996251509 0.447639066290155 no 1889 0.449708839864318 2742 953673
SGTC_2318 6029776 164 µM -0.126468384009387 0.447610509527127 no 1890 0.449680586988525 2739 818325
SGTC_2522 biochanin a 4.94 µM -0.126795945607721 0.447479480755422 no 1891 0.449550952387213 2737 5280373 A possible chelator.
SGTC_2438 5259590 200 µM -0.128620833824419 0.446749607752137 no 1892 0.448828840116134 2746 1201127
SGTC_2597 laccaic acid a 100 µM -0.128941377302921 0.446621423364509 no 1893 0.448702017789821 2728 5491415 A textile dye.
SGTC_65 0798-0905 34.986 µM -0.129216439494956 0.44651143125441 no 1894 0.448593194213362 2974 3602145
SGTC_1913 st060213 96.1 µM -0.129596513358658 0.446359453758462 no 1895 0.448442830960121 2709 688959
SGTC_19 0279-0214 38.434 µM -0.130134599743787 0.446144306371753 no 1896 0.448229968115152 2637 3566274 YBR002C RER2
SGTC_987 1497-1013 404 µM -0.130157219465101 0.446135262494327 no 1897 0.448221020252999 2632 1676435
SGTC_2992 9074591 71.4286 µM -0.13120010119308 0.445718325239536 no 1898 0.447808507954985 2638 17741321
SGTC_2536 dehydroabietamide 32.04 µM -0.132677605926908 0.44512773142844 no 1899 0.447224177073599 2760 3983547
SGTC_3353 9151644 39.2805 µM -0.137323767692231 0.443271349507218 no 1900 0.445387442249804 2755 4909158
SGTC_1643 st009866 20.2 µM -0.137426724600532 0.443230226841167 no 1901 0.445346754135339 2678 3156273 YOR207C RET1
SGTC_1203 3992-3522 103 µM -0.140809885487711 0.441879280016241 no 1902 0.444010066694996 2963 5322312
SGTC_1131 3454-3128 32.3 µM -0.141614417294637 0.441558117283427 no 1903 0.443692289177811 2846 710982
SGTC_2970 9090938 41.86 µM -0.142151316626891 0.441343812679326 no 1904 0.443480242443598 2771 17217104
SGTC_2420 aureobasidin a 50 nM -0.142762921819228 0.441099709985173 no 1905 0.443238710581174 2956 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_964 1287-0107 19.4 µM -0.143609427357558 0.440761891248911 no 1906 0.442904447937779 2772 51516812 YPR165W RHO1
SGTC_996 3970-0799 1.8 µM -0.144294915881921 0.440488361864105 no 1907 0.442633796417033 2732 6615648 YGL040C HEM2
SGTC_1613 st002381 52.1 µM -0.144665519898017 0.44034049215603 no 1908 0.4424874819272 2674 551167
SGTC_2048 5246248 200 µM -0.145069450897115 0.440179334574557 no 1909 0.442328018877025 2691 677046
SGTC_401 neomycin 50 µM -0.146080237218039 0.439776101559699 no 1910 0.441929023731578 2699 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_391 gliotoxin 8.33 µM -0.146123804013637 0.439758722857991 no 1911 0.441911827610187 2791 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2175 5807670 165.306 µM -0.146370323853056 0.439660388808284 no 1912 0.441814526554674 2693 241186
SGTC_1156 4092-0367 4.88 µM -0.147445211894579 0.43923167138371 no 1913 0.441390310766017 2685 1357585
SGTC_856 0433-0016 11.3 µM -0.14766968392202 0.439142150043611 no 1914 0.441301729006262 2738 3911780
SGTC_2704 st078022 71.1 µM -0.148735468137028 0.438717148848468 no 1915 0.440881186492147 2801 54697681
SGTC_924 2046-0044 21.3 µM -0.149169998937324 0.438543891890847 no 1916 0.440709746238677 2654 3623589
SGTC_2024 5144227 134 µM -0.151014417523306 0.437808613234847 no 1917 0.439982171396194 2823 3475211
SGTC_1486 3970-0793 4.53 µM -0.151201323376123 0.437734115033946 no 1918 0.439908453197334 2776 2844330
SGTC_370 0180-0345 38.7 µM -0.151334057273918 0.437681210397925 no 1919 0.439856102415887 2633 3989527
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.151428273269314 0.437643658775443 no 1920 0.439818943887633 2660 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_447 ml7 120 µM -0.152771668620723 0.437108283612545 no 1921 0.439289170298337 2741 4216 Selective myosin light chain kinase inhibitor.
SGTC_1269 0831-0796 3.05 µM -0.152834745244822 0.437083148892561 no 1922 0.439264298431981 2769 927758
SGTC_3249 9135183 49.47 µM -0.152846025055695 0.4370786541498 no 1923 0.439259850693081 2850 4902779
SGTC_2071 5230951 39.92 µM -0.153494739143483 0.436820170329305 no 1924 0.439004069351863 2687 1799272
SGTC_2411 st077133 39.94 µM -0.154035702663427 0.436604640954645 no 1925 0.438790792428903 2994 1403142 YNL221C POP1
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.154402402278585 0.436458552080462 no 1926 0.438646229814862 2758 16725076
SGTC_2343 7990716 14.84 µM -0.154685939465795 0.436345600093441 no 1927 0.438534457622904 2702 6456862
SGTC_212 3807-4682 38.772 µM -0.156613318373 0.435577933092574 no 1928 0.4377748027679 2751 3125501 YBL034C STU1
SGTC_724 3910-0327 137 µM -0.15673892219712 0.435527914004089 no 1929 0.437725305352048 2725 2885483
SGTC_16 erodoxin 22.806 µM -0.158459706872261 0.434842751795821 no 1930 0.437047284361641 2692 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1621 st003705 32.4 µM -0.158602773204261 0.434785796072588 no 1931 0.436990921876969 2849 24207032
SGTC_1712 st032288 53.4 µM -0.15880107971768 0.434706851078856 no 1932 0.436912799057588 2736 2883011
SGTC_553 k007-0256 45.7 µM -0.159476129319664 0.434438136186884 no 1933 0.436646881833382 2738 6287000
SGTC_1611 st001856 99.4 µM -0.15966892527434 0.434361396056745 no 1934 0.436570940419766 2710 647478
SGTC_495 decylubiquinone 155 µM -0.159694952217435 0.434351036531907 no 1935 0.436560688709157 2738 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_970 1315-0089 19.5 µM -0.160822316841174 0.433902354056752 no 1936 0.436116673864068 2685 6811083 YLR033W RSC58
SGTC_2636 apigenin dimethyl ether 100 µM -0.161055963034854 0.433809375296851 no 1937 0.436024661888341 2821 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2170 morpholine 200 µM -0.161208483333816 0.433748682304204 no 1938 0.435964599888204 2801 121171 Reacts with secondary amines.
SGTC_1917 st066507 28.5 µM -0.165456293549454 0.432058967365065 no 1939 0.434292424164181 2699 3156428
SGTC_1038 k292-0204 154 µM -0.16611324537327 0.431797751949278 no 1940 0.434033915336582 2689 4454212
SGTC_1830 st055982 50.3 µM -0.167611735301619 0.43120203816989 no 1941 0.433444369191015 2683 455313 An antimicrobial agent.
SGTC_791 1348-1292 225 µM -0.169103636047129 0.430609099301974 no 1942 0.432857562484236 2782 5437054
SGTC_979 1426-2828 121 µM -0.170164967737309 0.43018738030403 no 1943 0.432440200783739 2831 747872
SGTC_2520 obtusaquinone 4.71 µM -0.170921000850536 0.42988701989794 no 1944 0.432142941679087 2885 5967872
SGTC_2414 st077232 92.9 µM -0.174651927398653 0.428405377189945 no 1945 0.430676571721485 2691 729801
SGTC_257 daunorubicin 18.5 µM -0.175245813930804 0.428169622753974 no 1946 0.430443243491025 2837 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1668 st014914 51.6 µM -0.178415031938992 0.426911977447084 no 1947 0.429198522458573 2721 2839556
SGTC_716 1683-5115 658 µM -0.178893200586936 0.426722289260181 no 1948 0.429010780905156 2699 723597
SGTC_656 4090-1979 187 µM -0.18003921304646 0.426267738328268 no 1949 0.428560891798141 2813 22330961
SGTC_696 1560-0013 611 µM -0.18050601975578 0.426082613555654 no 1950 0.42837766446798 2921 1650269
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.180673885751482 0.426016045753772 no 1951 0.428311778788133 2834 7104
SGTC_1968 st069590 43.6 µM -0.18193851514808 0.42551462078263 no 1952 0.427815489090362 2852 6384066
SGTC_2400 5203494 178.7 µM -0.182232575298394 0.425398043298487 no 1953 0.427700104798041 2687 6777674
SGTC_3093 9117344 49.47 µM -0.183373455630442 0.4249458134478 no 1954 0.42725250102423 2876 24824913
SGTC_3157 9099274 49.47 µM -0.183453203063721 0.424914206307513 no 1955 0.427221217055086 2781 17217662
SGTC_194 1486-1323 56.904 µM -0.183618074264819 0.424848862698402 no 1956 0.427156541496165 2754 5178754
SGTC_1360 1598-0022 39.8 µM -0.184002903124807 0.424696351033335 no 1957 0.427005588722772 2830 761525
SGTC_1280 0880-0253 10.1 µM -0.185137564751139 0.424246738571873 no 1958 0.426560569228643 2775 6836607
SGTC_1019 4262-0212 3.4 µM -0.186649231412792 0.423647890165586 no 1959 0.425967831947283 2799 4677213
SGTC_2682 pyrogallin 40.03 µM -0.186820273257465 0.423580142828224 no 1960 0.425900775499828 2779 822798 An ATP competetive kinase inhibitor.
SGTC_1879 gemcitabine 100 µM -0.187541154366827 0.423294636518164 no 1961 0.425618179769129 2756 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1317 1273-0028 910 nM -0.188491063491006 0.422918484755506 no 1962 0.425245860132653 2769 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_3142 9086498 49.47 µM -0.189452777085611 0.42253773015223 no 1963 0.424868981606421 2867 25236367
SGTC_1229 0139-0193 12.2 µM -0.190128402291236 0.422270284824395 no 1964 0.424604257094596 2848 3090752
SGTC_2128 5255449 168.493 µM -0.190886206380625 0.421970351739785 no 1965 0.424307373589774 2757 736008
SGTC_1309 pyrazolanthrone 13.4 µM -0.191220797427278 0.421837937543617 no 1966 0.424176305131121 2832 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2222 6885208 172.143 µM -0.192936613925942 0.4211590434006 no 1967 0.423504304974973 2778 609514
SGTC_563 tetrahydrosecaminediol 614 µM -0.193161397965486 0.421070120807413 no 1968 0.423416284661527 2887 334274 A psychoactive constituent of the cannabis plant.
SGTC_3262 9137218 49.47 µM -0.193834438898328 0.420803895814426 no 1969 0.423152760021101 2692 17650664
SGTC_2765 myclobutanil 7.74 µM -0.195066344593882 0.420316702721606 no 1970 0.422670504778007 2857 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_681 1642-0006 26.6 µM -0.195246613558323 0.420245420313215 no 1971 0.422599944424456 2741 4446530
SGTC_509 pifithrin 175 µM -0.196686452335407 0.419676169707819 no 1972 0.422036456238009 2763 4817 A p53 inhibitor.
SGTC_1124 fisetin 1.16336 µM -0.199031144867497 0.418749538799698 no 1973 0.421119190931479 2826 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1310 1188-0297 994 nM -0.200763170842698 0.418065324997847 no 1974 0.420441880981902 2812 1588352
SGTC_144 4161-2749 112.381 µM -0.201569684059386 0.417746807155231 no 1975 0.42012657366887 2762 797501 YMR168C CEP3
SGTC_989 1501-0895 10.3 µM -0.201574431683734 0.41774493232619 no 1976 0.42012471773097 2785 2830112
SGTC_358 0075-0058 9.45 µM -0.20166794188138 0.417708005684146 no 1977 0.420088163153715 2676 1069125
SGTC_650 1328-0195 38 µM -0.201777778576675 0.417664632728303 no 1978 0.420045227177341 2778 2780821
SGTC_3114 9122766 49.47 µM -0.204479284645566 0.416598162774528 no 1979 0.418989489232846 2812 17176985
SGTC_952 1185-0122 232 µM -0.206425198868341 0.415830356495904 no 1980 0.418229394414184 2728 678600
SGTC_985 1493-0307 8.71 µM -0.20661662392934 0.41575484253537 no 1981 0.418154638193582 2893 3278274
SGTC_589 1227-0070 34.1 µM -0.206619426364337 0.415753737045089 no 1982 0.41815354379536 2897 2841384
SGTC_489 paxilline 115 µM -0.207100534800319 0.415563961729376 no 1983 0.417965672220846 2831 105008 A toxic potassium channel blocker.
SGTC_2188 6126565 140.678 µM -0.207126297610985 0.415553800031729 no 1984 0.41795561243891 2872 874518
SGTC_1255 0566-0045 221 µM -0.207387001892448 0.415450972889426 no 1985 0.417853816465601 2923 2788469
SGTC_2223 6903751 107.57 µM -0.207459163275388 0.415422511975402 no 1986 0.417825640922394 2871 5598863
SGTC_746 1095-0025 46.6 µM -0.209489786806665 0.414621803450789 no 1987 0.41703295373044 2953 6749286
SGTC_2790 5423970 71.43 µM -0.209531540878193 0.414605342837758 no 1988 0.417016657870637 2938 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_515 4092-1064 102 µM -0.211480612597319 0.413837132059524 no 1989 0.416256129506202 3003 717353
SGTC_2521 angolensin 13.4 µM -0.213572706027957 0.413012917276547 no 1990 0.4154401428621 2928 821428 A flavenoid.
SGTC_1302 1159-0335 255 µM -0.213652984944562 0.412981297683597 no 1991 0.415408838630875 2781 649284
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.213811738804436 0.412918770693931 no 1992 0.415346935196785 2800 6708514
SGTC_1235 benzylparaben 21.5 µM -0.215075710960289 0.412421020015211 no 1993 0.414854145308265 2877 7180
SGTC_1250 0485-0349 40.2 µM -0.215960886897302 0.412072522613315 no 1994 0.414509117923085 2814 6842794 YDL195W SEC31
SGTC_387 norethindrone acetate 66.7 µM -0.216825694525671 0.411732111248722 no 1995 0.414172093467504 2834 541197
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.217141002229665 0.411608014230893 no 1996 0.414049230508941 2727 4000243
SGTC_1516 st013856 110 µM -0.217574796357661 0.411437298450141 no 1997 0.413880211820173 2915 5281404 A mutagen and neurotoxin.
SGTC_2843 9000894 45.46 µM -0.218644963443398 0.411016215576434 no 1998 0.413463312175887 2745 2242070
SGTC_2481 5478948 45.16 µM -0.218926297568694 0.410905534923091 no 1999 0.413353730419038 2931 77792
SGTC_2834 9001755 58.44 µM -0.220206806091955 0.410401855274485 no 2000 0.412855048114749 2884 2989575
SGTC_1092 toremifene 6.32 µM -0.221107218805369 0.410047772246684 no 2001 0.41250447478308 2787 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2749 bexarotene 57.39 µM -0.221241883212329 0.409994822404302 no 2002 0.412452049541534 2882 82146 An retinoic acid receptor inhibitor.
SGTC_220 paclitaxel 373.376 µM -0.222432258307048 0.409526840183035 no 2003 0.41198870111612 2896 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1184 1269-1718 139 µM -0.222766860814116 0.409395318248358 no 2004 0.411858480577809 2951 5403821
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.223893168477588 0.408952676428214 no 2005 0.41142021578566 2820 17037758
SGTC_2335 9018011 154.17 µM -0.224926473200677 0.408546687092284 no 2006 0.411018237144891 2905 6458208
SGTC_2476 5806916 10.51 µM -0.225388939582704 0.408365014061703 no 2007 0.41083835761854 2816 2870194
SGTC_2528 xanthyletin 44.79 µM -0.225686998537137 0.408247936474213 no 2008 0.410722435441758 2810 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1821 st053465 65.6 µM -0.226190042045395 0.408050359514319 no 2009 0.410526807614583 2879 675086
SGTC_178 4092-0806 87.505 µM -0.226651024572125 0.40786932308457 no 2010 0.410347556361752 2866 2169044
SGTC_2016 5121758 140 µM -0.226840810840998 0.407794796193246 no 2011 0.410273764153404 2749 2795203
SGTC_1010 4112-3296 15.2 µM -0.227338701033315 0.407599296288662 no 2012 0.410080190876319 2963 704384
SGTC_2847 9005661 71.43 µM -0.229533434837157 0.406737794315718 no 2013 0.409227168480692 2850 2991449
SGTC_1991 st073000 8.92 µM -0.231195847835258 0.406085545019695 no 2014 0.408581327791018 3022 4301969 YIL048W NEO1
SGTC_1487 3970-0795 2.82 µM -0.231938596616417 0.405794210949181 no 2015 0.408292853021188 2899 3765103
SGTC_1709 st033179 39.1045 µM -0.23237478111904 0.405623147248296 no 2016 0.408123467311512 2821 573381
SGTC_449 xestospongin c 11.1929 µM -0.232570563933718 0.405546370615147 no 2017 0.408047443572266 2944 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_644 1498-1197 63.3 µM -0.233008306382926 0.405374722163384 no 2018 0.407877477860603 2928 6741615
SGTC_504 lovastatin 124 µM -0.234344197759694 0.404851002383082 no 2019 0.407358888090417 2844 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2948 9070189 9.45 µM -0.235726649771875 0.404309208478717 no 2020 0.406822394514337 2979 6473636 YDL196W YDL196W
SGTC_2714 st079313 56.9 µM -0.236336586595047 0.404070227669672 no 2021 0.406585749456331 2833 2939799
SGTC_2797 7859098 81.82 µM -0.236666229358787 0.40394108444401 no 2022 0.406457867894354 2847 972681
SGTC_3277 9138724 49.47 µM -0.237010577555789 0.40380619129254 no 2023 0.406324292162943 2889 15943418
SGTC_202 3594-0513 34.79 µM -0.237695402530442 0.40353795557291 no 2024 0.406058674870766 2799 708429
SGTC_2111 5486399 200 µM -0.23838686138531 0.403267167490648 no 2025 0.405790528415583 2830 689674
SGTC_850 0388-0143 75.9 µM -0.240002420861321 0.402634665479644 no 2026 0.405164189936406 2841 67273
SGTC_1591 genipin 88.4 µM -0.241028367563909 0.402233132847988 no 2027 0.404766565204578 2972 442424 A DNA cross-linking agent.
SGTC_833 3852-0053 558 µM -0.241517290700181 0.402041815512625 no 2028 0.404577108512613 2993 3123681
SGTC_538 2922-0838 53.3 µM -0.242039730013088 0.401837409117258 no 2029 0.404374689096627 3021 777039
SGTC_556 4058-0063 51.5 µM -0.242078362805704 0.401822294953665 no 2030 0.404359721814292 2872 6615692
SGTC_1831 st055328 12 µM -0.242138737135588 0.401798675223461 no 2031 0.404336331612581 3003 1103068
SGTC_2832 7992762 51.95 µM -0.242346839141008 0.401717264013907 no 2032 0.40425571142769 2802 2985177
SGTC_2329 6138490 200 µM -0.242589660507185 0.401622275697935 no 2033 0.404161645857642 3081 720019
SGTC_1804 st050076 49.1 µM -0.242963710263164 0.401475964049303 no 2034 0.40401675510509 2955 3895976
SGTC_150 3970-0969 77.2 µM -0.245068782949418 0.400652811276959 no 2035 0.403201586797212 2947 6615640
SGTC_2621 lithochol-11-enic acid 100 µM -0.245567523124926 0.40045785191718 no 2036 0.403008516138595 2889 6708711
SGTC_505 gw-5074 63.9 µM -0.248953762436145 0.399134816696831 no 2037 0.401698273862911 2946 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1728 st035614 33.7865 µM -0.250388742556213 0.39857450499868 no 2038 0.401143367272692 2948 15945546
SGTC_787 4152-0075 138 µM -0.250575933906056 0.398501428429266 no 2039 0.40107099508198 2863 9566539
SGTC_2616 abietic acid 100 µM -0.250963113309979 0.398350290953531 no 2040 0.400921313994755 2962 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1555 citronellol 128 µM -0.251234340261447 0.398244425195319 no 2041 0.400816468047027 2928 8842 A terpine precursor.
SGTC_3202 9113761 49.47 µM -0.251378114253392 0.398188310126675 no 2042 0.400760893427023 3025 4798415
SGTC_2717 st081029 62.2815 µM -0.252441814343067 0.397773212882125 no 2043 0.400349791629178 2958 5292846
SGTC_337 1315-0038 354 µM -0.25248884296514 0.39775486314784 no 2044 0.400331618419893 2868 1626437
SGTC_2649 anisomycin 9.56 µM -0.252529143834621 0.397739138643278 no 2045 0.400316045178989 2899 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3198 9112019 49.47 µM -0.253931224919662 0.397192181336144 no 2046 0.399774345620191 2841 45595555
SGTC_2074 5212007 75.395 µM -0.254337244512033 0.39703382920104 no 2047 0.399617514309855 2921 758611
SGTC_1698 5-fluorocytosine 1.055 µM -0.256555659945328 0.396168923014775 no 2048 0.398760903845406 2986 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2206 7254556 146.969 µM -0.257302217560706 0.395877973037515 no 2049 0.398472740353297 2897 4398905
SGTC_570 0987-0065 62.6 µM -0.257792865210432 0.395686788397027 no 2050 0.398283385583971 2796 3104428
SGTC_1702 st027038 51 µM -0.258805475488556 0.395292296385588 no 2051 0.397892666476761 2915 5521182
SGTC_376 3970-0862 59.1 µM -0.25923164706723 0.395126300810265 no 2052 0.397728257319164 2990 3135186
SGTC_2877 9040724 71.43 µM -0.259600178915446 0.394982771488682 no 2053 0.397586099152413 3069 6463895
SGTC_3264 9137442 49.47 µM -0.259765285285568 0.39491847337584 no 2054 0.397522415121524 3102 17015726
SGTC_2122 5258151 111.688 µM -0.260117069679237 0.39478148595097 no 2055 0.397386735657186 2890 2173356
SGTC_942 3253-1115 227 µM -0.261112332902532 0.394393993657578 no 2056 0.397002940615203 3050 46497897
SGTC_1 0258-0098 57.368 µM -0.261662935599323 0.394179668799444 no 2057 0.396790659120745 2924 6790032 YDR047W HEM12
SGTC_1126 isoteolin 1.0172 µM -0.262824782063116 0.39372751944792 no 2058 0.396342816762593 2863 133323
SGTC_2564 betulinic acid 100 µM -0.264274141635651 0.393163681067845 no 2059 0.395784342078181 3167 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_999 SEC7.066 22.7 µM -0.264535042342418 0.393062207701327 no 2060 0.395683833159051 2872 740511 YDR170C SEC7
SGTC_3134 9127454 49.47 µM -0.264723942636853 0.39298874233574 no 2061 0.395611065878263 2935 24262820
SGTC_1773 st048542 73.5835 µM -0.264813603769279 0.392953873486232 no 2062 0.395576528312867 2848 3237138
SGTC_2677 mitomycin C 100 µM -0.266461637906965 0.392313112977375 no 2063 0.394941850103414 2902 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_474 dl-dihydrosphingosine 5 µM -0.271071582278133 0.390522308206911 no 2064 0.393167988814178 3022 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1209 2323-2347 50.3 µM -0.271167259975427 0.390485165158395 no 2065 0.393131196321562 2926 5412760
SGTC_2430 5571206 200 µM -0.272783094822482 0.389858032971692 no 2066 0.392509977647095 3054 1731771
SGTC_3266 9136860 49.47 µM -0.273104267619132 0.38973341460089 no 2067 0.392386533152091 2958 4871271 YPR165W RHO1
SGTC_2987 9018338 71.43 µM -0.273907315205373 0.389421873451212 no 2068 0.392077924892053 2903 5055682
SGTC_2760 etidronate 98.04 µM -0.274338148684526 0.389254761499632 no 2069 0.391912385120122 2914 3305 A chelator and antioxidant.
SGTC_3250 9135583 49.47 µM -0.274424959438422 0.389221091769856 no 2070 0.391879032065711 3025 7699353
SGTC_1345 1488-0192 31.4 µM -0.275869607502504 0.388660904315464 no 2071 0.391324109052476 3038 658348
SGTC_1423 4048-0112 5.59 µM -0.276137845040304 0.388556915980511 no 2072 0.391221097065631 2969 X1423
SGTC_674 0498-0004 451 µM -0.276389667308721 0.388459298663104 no 2073 0.391124396022713 2956 4231473
SGTC_1138 3761-0006 1.03 µM -0.276667854926139 0.388351469173723 no 2074 0.391017578374874 2879 12061087
SGTC_3288 9119690 36.221 µM -0.276738398904073 0.388324126688781 no 2075 0.390990492415965 2938 17595618 YKL019W RAM2
SGTC_1322 1348-1070 12 µM -0.277335741529874 0.388092621940474 no 2076 0.390761158854215 2958 6758089
SGTC_662 k832-1615 104 µM -0.27748708319852 0.388033974617771 no 2077 0.390703061338331 2990 5878478
SGTC_2909 7941780 10.49 µM -0.277894667472593 0.387876041880076 no 2078 0.390546608741551 3024 1243215
SGTC_1148 3909-7663 27.7 µM -0.280019599148675 0.387052963952272 no 2079 0.38973123410808 3032 4084526
SGTC_3192 9110362 49.47 µM -0.282035298138528 0.386272665604356 no 2080 0.388958222237574 2856 16649480
SGTC_216 k038-0035 28.382 µM -0.282672670837644 0.386026027425645 no 2081 0.38871388384132 2993 4444231 YPR107C YTH1
SGTC_2958 9077254 16.72 µM -0.28300248346766 0.385898420979314 no 2082 0.388587466632208 3102 16457351
SGTC_2146 5545642 200 µM -0.283314732975878 0.385777621184391 no 2083 0.388467792242176 2929 825326
SGTC_2724 maprotiline 69.64 µM -0.28408481129049 0.385479748777912 no 2084 0.388172693245888 2994 4011 A tricyclic antidepressant.
SGTC_423 5-fluorouracil 457 µM -0.284735596718891 0.385228072452728 no 2085 0.387923358375658 2842 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.285176234419005 0.385057693372285 no 2086 0.387754563450318 2888 442882
SGTC_784 4579-0127 173 µM -0.285215966241021 0.385042331566058 no 2087 0.387739344437528 3099 1948547
SGTC_615 k087-0205 167 µM -0.285222819657864 0.385039681797401 no 2088 0.387736719298775 2922 9642773
SGTC_3144 9087057 49.47 µM -0.286637350176199 0.384492890307606 no 2089 0.387195006294186 3015 17249618
SGTC_3031 9088762 49.47 µM -0.286796081780572 0.384431546392665 no 2090 0.387134231630811 2861 205253
SGTC_2221 6807166 181.081 µM -0.287192495024362 0.384278359925939 no 2091 0.386982466245293 2974 674925
SGTC_3060 1327-0027 12.5 µM -0.287579005721453 0.384129017513532 no 2092 0.386834508649058 2979 16000455 YPR107C YTH1
SGTC_3309 9129340 25.759 µM -0.287620315645891 0.384113056944562 no 2093 0.38681869604327 2946 17158987
SGTC_2894 9048625 32.47 µM -0.288817001368893 0.383650788928258 no 2094 0.386360710539834 3094 4092861
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.289087769213436 0.383546216894963 no 2095 0.386257106480165 2984 77254
SGTC_3313 9133968 57.047 µM -0.289316207728583 0.383457999278131 no 2096 0.386169705223267 2869 1494643
SGTC_3254 9136651 49.47 µM -0.290588102864599 0.382966933677802 no 2097 0.385683180081507 2952 16454030
SGTC_2446 5162541 200 µM -0.291784700736792 0.382505111221908 no 2098 0.3852256217603 2884 1549321
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.292450312271483 0.38224829321091 no 2099 0.384971172524363 3025 140250 A respiratory chain inhibitor.
SGTC_2115 tiliquinol 12.7705 µM -0.292801823760279 0.382112687724179 no 2100 0.384836817081068 3005 71208 A bioactive hydroxyquinoline.
SGTC_623 k072-0108 16.9 µM -0.294229772877875 0.38156196485809 no 2101 0.38429116577533 2988 5382803
SGTC_1442 4112-3290 3 µM -0.295180090276637 0.381195584894286 no 2102 0.383928155200051 2929 704353
SGTC_325 2810-4341 181 µM -0.295512189343939 0.381067574395194 no 2103 0.383801321077468 3034 774970
SGTC_1182 1222-0449 220 µM -0.296413949762402 0.38072004861358 no 2104 0.383456986690652 2996 658318
SGTC_1943 st076331 65.2 µM -0.297390048031536 0.380343982518031 no 2105 0.383084370355179 3027 24208415
SGTC_2831 7999036 19.48 µM -0.298465568564253 0.37992974246641 no 2106 0.382673925750735 3201 2988270
SGTC_3355 9151058 44.0485 µM -0.29983468184632 0.379402623557009 no 2107 0.382151629703778 2962 17015728
SGTC_1249 0481-0015 10.2 µM -0.300041584676033 0.379322983879609 no 2108 0.382072718021232 2895 4227577
SGTC_700 3453-2283 142 µM -0.300502284823066 0.379145672606505 no 2109 0.381897026940021 3116 565664
SGTC_2174 5790901 200 µM -0.301242203481016 0.37886095075011 no 2110 0.381614904926093 3017 786020
SGTC_3132 9126706 49.47 µM -0.301273155571882 0.37884904176829 no 2111 0.381603104638244 3143 850858
SGTC_2293 7624732 200 µM -0.301935696061522 0.378594153384171 no 2112 0.38135054169249 2889 894453
SGTC_3139 9095020 49.47 µM -0.302309181413546 0.378450491729524 no 2113 0.381208189920299 2835 25236292
SGTC_534 k292-0788 63.4 µM -0.303207953850718 0.378104846561427 no 2114 0.380865693935412 3107 4146317
SGTC_975 1335-0046 28.5 µM -0.304293013034645 0.377687690197366 no 2115 0.380452333864284 2968 16486740
SGTC_701 4424-0219 185 µM -0.305372401838581 0.377272855334933 no 2116 0.380041269350245 3122 2911779
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.305856736902788 0.377086759805913 no 2117 0.379856863640593 2964 115019
SGTC_978 1416-0512 87.4 µM -0.305877630752708 0.377078732426912 no 2118 0.37984890913147 3013 6814003
SGTC_1348 1493-0373 93.8 µM -0.306409640573993 0.376874353131453 no 2119 0.379646384514688 3003 3010129
SGTC_2946 9065502 71.43 µM -0.306771782609266 0.376735250741625 no 2120 0.379508543765538 2979 16489101
SGTC_1178 0988-0033 191 µM -0.307288474215812 0.376536812016004 no 2121 0.379311903912656 3090 5392207
SGTC_2274 7947094 46.08 µM -0.308321822071129 0.376140046052202 no 2122 0.378918731361433 2951 2971028
SGTC_1934 st074720 32.6 µM -0.309016594623714 0.375873353576035 no 2123 0.378654451760262 2933 17250992
SGTC_630 4356-0227 183 µM -0.309233521461054 0.375790097088615 no 2124 0.378571948116775 2964 779312
SGTC_1706 st031321 9.9705 µM -0.310485797169951 0.375309587012698 no 2125 0.378095779206083 3064 6103185
SGTC_1696 st025591 34.7925 µM -0.310509879280641 0.375300348371319 no 2126 0.378086623967091 2957 2787147
SGTC_851 0394-0702 453 µM -0.310945644502595 0.375133187736258 no 2127 0.377920971966614 3086 762646
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.311133713847771 0.375061051104593 no 2128 0.377849486127439 3132 688798
SGTC_3111 9122088 49.47 µM -0.311193437236761 0.37503814427629 no 2129 0.377826785925956 2993 16876704
SGTC_3063 1327-0034 4 µM -0.311931992346636 0.374754908873518 no 2130 0.377546104164256 3041 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_514 4466-0038 2.65 nM -0.313195784585614 0.37427040213369 no 2131 0.37706596042884 2992 5722064
SGTC_372 0155-0182 15.9 µM -0.313496546028114 0.37415512683588 no 2132 0.376951722204592 2936 771486
SGTC_1337 1486-1011 40.3 µM -0.314372292036563 0.37381953661273 no 2133 0.376619148955962 2970 X1337
SGTC_1511 0906-3109 28.5 µM -0.318349396249228 0.372296697292532 no 2134 0.375109959456246 2960 2882180
SGTC_1234 0326-0494 15.5 µM -0.318465243690801 0.372252368914166 no 2135 0.37506602741063 3106 1547813
SGTC_1811 st050069 61.5 µM -0.319096344346802 0.372010911504624 no 2136 0.374826727834741 2999 3877702
SGTC_177 1327-0068 8.361 µM -0.319107581642157 0.372006612601448 no 2137 0.374822467334316 3050 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1363 1636-0063 10.4 µM -0.319287757409617 0.371937687324767 no 2138 0.374754157704483 2972 6072185
SGTC_249 wiskostatin 11.211 µM -0.31979759905601 0.371742672371177 no 2139 0.374560883896891 3054 2775510 A n-wasp and actin depolymerizer.
SGTC_2606 farnesol 9.78 µM -0.321509695286071 0.371088034857654 no 2140 0.3739120830937 3145 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1418 3966-3099 2.4 µM -0.322679365220607 0.370641013841221 no 2141 0.373469040526794 3067 740335
SGTC_1072 oxiconazole 14.9 nM -0.322926074593759 0.370546749452935 no 2142 0.373375614339532 2995 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2026 5148700 152 µM -0.322976717131652 0.37052740057024 no 2143 0.373356437475433 2941 79838
SGTC_2914 7968218 45.32 µM -0.323181751540586 0.370449066873742 no 2144 0.373278800082183 3065 2977111
SGTC_1903 st060211 78.3 µM -0.324257708660601 0.370038084001543 no 2145 0.372871467470088 3141 688960
SGTC_804 1595-0054 20.9 µM -0.325264877850199 0.369653510445512 no 2146 0.37249030513059 2990 761523 Stimulates phospholipase C.
SGTC_448 monastrol 171 µM -0.32555110187234 0.36954424355011 no 2147 0.372382006654555 3023 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2464 5717415 7.67 µM -0.326643704766194 0.369127235990642 no 2148 0.371968691755998 2998 5285744
SGTC_1981 st071826 47 µM -0.326936774032886 0.369015408072487 no 2149 0.371857853219133 3063 11838600
SGTC_2220 6782180 200 µM -0.326990309706025 0.368994981392977 no 2150 0.371837607221886 3050 833803
SGTC_217 ketoconazole 989 nM -0.328141208900115 0.368555942284287 no 2151 0.371402448615105 3062 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_355 1311-2252 105 µM -0.329425336207104 0.368066282478858 no 2152 0.370917110004543 3005 5338538
SGTC_1298 1079-1278 263 µM -0.330171909681279 0.367781699635802 no 2153 0.370635035307987 3008 2840950
SGTC_3004 9076122 71.4286 µM -0.33078072208822 0.367549682998693 no 2154 0.370405061749081 3139 44782551
SGTC_885 0865-0106 16.8 µM -0.332845254538504 0.366763256017833 no 2155 0.369625547909653 2993 2793380
SGTC_1882 5615643 20 µM -0.333285350758962 0.3665956856011 no 2156 0.369459448145357 3048 2253075
SGTC_2314 7727897 200 µM -0.335601164462408 0.365714339215851 no 2157 0.368585822886078 2982 900724
SGTC_143 4032-1194 15.74 µM -0.335762989744404 0.365652778594831 no 2158 0.36852480070121 2930 1806963
SGTC_718 1130-0073 349 µM -0.335792372445788 0.365641601371661 no 2159 0.368513721226692 3166 6740020
SGTC_1307 1187-1599 12.2 µM -0.337453602785241 0.365009852694104 no 2160 0.36788749128534 2985 1538471
SGTC_799 1310-0557 151 µM -0.337782454570756 0.36488483714156 no 2161 0.36776356639668 3154 5354492
SGTC_580 1123-0028 41 µM -0.338586331912773 0.364579297438461 no 2162 0.367460690300344 2995 1677248 YPR107C YTH1
SGTC_201 4262-0159 12.803 µM -0.339152554022228 0.364364137941433 no 2163 0.367247404804131 3058 1341029
SGTC_463 ikarugamyin 104 µM -0.339768785744685 0.364130023785705 no 2164 0.367015328144805 3053 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1590 st077108 57.8 µM -0.341640754439539 0.363419150639747 no 2165 0.366310631512359 3113 5489485
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.342110417878511 0.363240871366344 no 2166 0.366133898824776 3155 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1183 1254-0324 198 µM -0.342638304210291 0.363040526658961 no 2167 0.365935290963398 3143 5799357
SGTC_586 0957-0265 8.15 µM -0.347092946823375 0.361351387100034 no 2168 0.364260746067113 3111 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2650 prasterone 100 µM -0.347659881718791 0.361136606082963 no 2169 0.364047814519221 3065 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1063 disulfiram 1.84 µM -0.348033542076236 0.360995070278104 no 2170 0.363907496692031 3029 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_486 niguldipine 82 µM -0.348275036285971 0.360903606749767 no 2171 0.363816819917367 3022 1236 A calcium channel blocker.
SGTC_927 2425-1185 123 µM -0.348446633230196 0.360838620948607 no 2172 0.363752392955407 2977 730375
SGTC_1748 st037455 53.6035 µM -0.349788877708905 0.360330435776459 no 2173 0.36324857335257 3189 580690
SGTC_1652 st011932 78 µM -0.350458413311476 0.360077036050531 no 2174 0.362997347459095 3123 1551076
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.351697929188453 0.359608077703315 no 2175 0.362532406870912 3011 279621
SGTC_2309 7664088 163.95 µM -0.352657820266623 0.35924505773626 no 2176 0.362172492327727 3202 704922
SGTC_2964 9083345 53.42 µM -0.352913024849552 0.359148563608048 no 2177 0.36207682295656 3073 17741579
SGTC_1733 st037357 54.9 µM -0.353555560127157 0.358905657607714 no 2178 0.361835991836532 2946 1272339 YGL099W LSG1
SGTC_197 4544-0043 41.561 µM -0.353632951671754 0.358876404118913 no 2179 0.361806988103429 3006 896523
SGTC_2754 granisetron 64.02 µM -0.354349213679381 0.358605701145766 no 2180 0.361538595019429 3151 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2703 st077852 53.4 µM -0.355205452726027 0.358282188669341 no 2181 0.361217840029875 3150 6281836
SGTC_338 4055-0136 114 µM -0.355274474577065 0.358256114596104 no 2182 0.361191988057808 3022 2900563
SGTC_69 0096-0274 206.684 µM -0.355334384237812 0.358233483329717 no 2183 0.361169549549107 3306 6741392
SGTC_2080 5212524 12.4 µM -0.356304333195896 0.357867148120397 no 2184 0.360806332286748 3138 260183
SGTC_908 3448-7491 47.7 µM -0.35655443349512 0.357772710187394 no 2185 0.360712697445838 3006 1203031
SGTC_1630 st005209 31.3 µM -0.35655462641321 0.357772637344836 no 2186 0.360712625222618 3133 3367314
SGTC_3036 9090181 49.47 µM -0.357285037144012 0.357496883952304 no 2187 0.360439215199372 3009 25236586
SGTC_2047 4141938 200 µM -0.358914735557652 0.356881889030896 no 2188 0.359829437867752 3072 3807862
SGTC_3104 9120930 49.47 µM -0.359332799878569 0.356724185071443 no 2189 0.359673069927943 3134 17014836
SGTC_2448 5185112 27.17 µM -0.359641846218089 0.356607621067485 no 2190 0.359557492910278 3162 5718189
SGTC_2363 9053361 176 µM -0.360134583095118 0.35642180161063 no 2191 0.359373245954622 3198 6469797 YMR079W SEC14
SGTC_760 0568-0725 82.9 µM -0.3601675010433 0.35640938890649 no 2192 0.359360938254082 3168 3916171
SGTC_209 4077-0173 175.592 µM -0.361261285659036 0.355997031035266 no 2193 0.358952065876339 3109 15993494
SGTC_1043 0916-0009 19.3 µM -0.363171290733295 0.3552773612544 no 2194 0.358238466153595 3221 3101130
SGTC_1341 1486-1360 280 µM -0.363212033066816 0.355262015582601 no 2195 0.358223249734285 3033 3976547
SGTC_2224 6650123 117.647 µM -0.363653693191527 0.355095678584639 no 2196 0.358058313263468 3064 2908370
SGTC_3188 9110789 49.47 µM -0.364019569139813 0.354957904153365 no 2197 0.357921698195033 3215 849217
SGTC_1403 3909-7815 62.9 µM -0.364059182400332 0.354942988501487 no 2198 0.357906908020802 3014 6615483
SGTC_92 0063-0024 660.874 µM -0.366024957081576 0.354203091512844 no 2199 0.357173226413249 3076 3594437
SGTC_1061 3448-9325 110 µM -0.366376465192827 0.354070845436399 no 2200 0.357042089388235 3112 723482
SGTC_792 4534-1957 155 µM -0.368338924215557 0.353332843464162 no 2201 0.356310266111671 3062 1717904
SGTC_2827 7993847 71.43 µM -0.368876231027561 0.353130879955524 no 2202 0.356109990403292 3135 2985692
SGTC_3261 9137475 49.47 µM -0.369399274157036 0.352934317624952 no 2203 0.355915069462804 3088 17027690
SGTC_2373 9071805 200 µM -0.369481809212439 0.352903304105005 no 2204 0.355884314805904 3209 10149009
SGTC_1477 0139-0234 16 µM -0.369632210765446 0.35284679146187 no 2205 0.355828273780923 3100 620880
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.369736417587859 0.352807638165178 no 2206 0.355789447171489 3120 1241132 A phosphatase inhibitor.
SGTC_1324 1418-0026 34.4 µM -0.370380221153959 0.352565778486266 no 2207 0.355549604414354 3154 1372513
SGTC_1539 benzyladenosine 56 µM -0.370525758373209 0.352511112323076 no 2208 0.355495393860311 3051 92208 A nucleotide analog.
SGTC_2287 7945887 168.79 µM -0.371091933494547 0.35229847665865 no 2209 0.355284529457293 3143 1245853
SGTC_814 3342-0569 96 µM -0.372735527781212 0.351681461578285 no 2210 0.354672645764999 3110 4346283
SGTC_1863 st057641 20.1 µM -0.373453431845536 0.351412078552611 no 2211 0.354405499144573 3137 3921635
SGTC_605 1315-0399 119 µM -0.37414654097565 0.351152070256324 no 2212 0.354147647165344 3210 24020461
SGTC_3245 9134821 49.47 µM -0.376242813423407 0.350366113093034 no 2213 0.353368194620105 3069 17014901
SGTC_3319 9138450 16.7555 µM -0.376377838472728 0.350315509953739 no 2214 0.353318009576448 3054 2029690
SGTC_1253 0550-0034 176 µM -0.378103930412222 0.349668859370136 no 2215 0.352676694320176 3182 5969915
SGTC_256 clotrimazole 625 nM -0.379969693101974 0.348970373798258 no 2216 0.351983956163382 3136 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2842 9000675 19.48 µM -0.381159748797848 0.348525119629318 no 2217 0.351542357242554 3122 2989072
SGTC_1921 5740136 50 µM -0.381504304337361 0.348396244586839 no 2218 0.351414538945577 3240 1774243
SGTC_2156 5649887 115 µM -0.381673652940283 0.348332909083037 no 2219 0.351351722574776 3177 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_346 4513-0042 7.16 µM -0.383271887682327 0.34773538603483 no 2220 0.350759090547605 3033 2827372
SGTC_1856 st057054 55.7 µM -0.383302655102956 0.347723886896037 no 2221 0.350747685417551 3286 1266018
SGTC_1980 st071811 45.7 µM -0.383617077208534 0.347606381553614 no 2222 0.350631140460354 3224 4974850
SGTC_1469 k284-2957 126 µM -0.385077275250628 0.347060870628656 no 2223 0.35009008198209 3126 23884841
SGTC_1100 amiodarone 5.07 µM -0.385764606407385 0.346804202260386 no 2224 0.349835505067585 3177 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1845 st056753 3.01 µM -0.386082587052293 0.346685483310945 no 2225 0.349717752743776 3042 5375839
SGTC_3180 9109287 49.47 µM -0.386195399713315 0.346643368010495 no 2226 0.349675980237392 3196 18891271
SGTC_2665 lovastatin 100 µM -0.386601338614534 0.346491838302807 no 2227 0.349525683397714 3121 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2032 5185112 25.99 µM -0.387312046562805 0.346226602934929 no 2228 0.349262604154597 3119 5718189
SGTC_1841 st054148 70 µM -0.389153141827173 0.345539859301115 no 2229 0.34858143204893 3159 675442
SGTC_1750 st081859 2.357 µM -0.389915843025094 0.345255514198861 no 2230 0.348299389138039 3143 5291695
SGTC_2618 avocadyne 43.43 µM -0.390048776577599 0.345205963743201 no 2231 0.348250239584479 3062 3015189
SGTC_1411 3909-8223 150 µM -0.391676521187854 0.344599443780641 no 2232 0.347648620058373 3188 X1411
SGTC_847 0342-0274 5.54 µM -0.392322220123862 0.344358958021317 no 2233 0.347410073846839 3206 18097
SGTC_707 0865-0008 204 µM -0.392753389067308 0.344198407383542 no 2234 0.34725081696785 3082 723043
SGTC_2733 amorolfine 100 µM -0.39316553185078 0.344044967596741 no 2235 0.347098612813078 3157 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1287 0971-0001 34.6 µM -0.394059156741246 0.343712361375357 no 2236 0.34676868225528 3129 4665869
SGTC_1104 tacrolimus 29.8 µM -0.394118599046439 0.343690241300643 no 2237 0.346746739991582 3158 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_159 3970-0959 50 µM -0.394174253411103 0.343669531305205 no 2238 0.346726196457066 3243 6615653
SGTC_1014 4130-3005 69.3 µM -0.395166079683712 0.343300533552899 no 2239 0.346360162127534 3084 743608
SGTC_1855 st056195 39.6 µM -0.396368456482838 0.342853403122148 no 2240 0.345916616315263 3254 4028379
SGTC_512 prima-1 270 µM -0.396756762476431 0.34270904991299 no 2241 0.345773418903229 3250 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2761 levamisole 97.89 µM -0.399687996675293 0.341620102431215 no 2242 0.344693167066205 3250 26879 An alkaline phosphatase inhibitor.
SGTC_3276 9139060 49.47 µM -0.400945955175639 0.341153176714218 no 2243 0.344229957295973 3075 4870619
SGTC_1012 4112-3522 18 µM -0.401476873592041 0.340956184734531 no 2244 0.344034530761621 3259 3112398
SGTC_2065 5221596 34.26 µM -0.401776818267146 0.340844912417212 no 2245 0.343924142098075 3232 788581
SGTC_3205 9113483 49.47 µM -0.402424492902424 0.340604687818141 no 2246 0.343685823733104 3258 17018033
SGTC_976 1348-1067 47.6 µM -0.404049687605788 0.340002182681772 no 2247 0.343088090710241 3117 5310671 YGL099W LSG1
SGTC_236 1509-0011 5.31 µM -0.404454782876135 0.339852066059851 no 2248 0.342939161096834 3257 3107280
SGTC_2342 7990637 118.86 µM -0.405053331027724 0.339630307862979 no 2249 0.342719154945505 3217 2033102 YER133W GLC7
SGTC_912 3474-0017 2.18 µM -0.405541994950176 0.339449302208692 no 2250 0.342539578079576 3262 3360550
SGTC_2280 7785178 200 µM -0.405713770288438 0.339385683822946 no 2251 0.342476461598431 3106 2954328
SGTC_2228 7354201 200 µM -0.410532609270918 0.337602859017275 no 2252 0.340707643795602 3160 753451
SGTC_824 1304-0008 100 µM -0.411211927337678 0.337351823574159 no 2253 0.34045857157615 3139 768245
SGTC_2439 5492030 7.2 µM -0.411985306746117 0.337066116782759 no 2254 0.34017509641923 3207 5722370
SGTC_2491 paeonol 100 µM -0.41375516019213 0.336412639920631 no 2255 0.33952671283839 3081 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3172 9105863 49.47 µM -0.414146691664052 0.336268142750893 no 2256 0.339383339831036 3164 2348785
SGTC_1438 4092-1045 4 µM -0.415173122002384 0.335889446985731 no 2257 0.339007586692191 3139 1351342
SGTC_476 mead acid 10 µM -0.415416316772703 0.335799746019766 no 2258 0.33891858198492 3127 5312531 An omega 9 fatty acid.
SGTC_155 k072-0202 43.6 µM -0.416131068334223 0.335536168254525 no 2259 0.338657048432349 3212 5857737
SGTC_1758 st042942 75.2445 µM -0.417728233863811 0.334947476700059 no 2260 0.33807291349971 3221 669317
SGTC_41 0478-0632 82.643 µM -0.418803805807042 0.334551265087764 no 2261 0.337679761606213 3259 3750424
SGTC_1189 1431-2119 7.28 µM -0.421221989294164 0.333661144778705 no 2262 0.33679649440478 3221 3107275
SGTC_510 ag-490 170 µM -0.422577626056556 0.333162551041231 no 2263 0.336301726764755 3256 5328779
SGTC_1794 st048918 76.9 µM -0.422671892271645 0.333127891535206 no 2264 0.336267332890386 3202 672303
SGTC_637 1181-0519 7.26 µM -0.423551620471112 0.332804504580722 no 2265 0.33594642226568 3203 6252091 YGR060W ERG25
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.423633845949471 0.332774284951145 no 2266 0.33591643384666 3141 16486 A toxic proline analog.
SGTC_2386 9075165 157.42 µM -0.4259015079303 0.331941299169374 no 2267 0.335089808044158 3206 16452277
SGTC_711 k292-0785 179 µM -0.42737510135522 0.331400445128156 no 2268 0.334553069832075 3143 4146315
SGTC_2921 7974240 10.71 µM -0.427968954639924 0.331182582019669 no 2269 0.334336861581461 3261 2979074 YDR527W RBA50
SGTC_1018 4259-0013 28.1 µM -0.428601113149617 0.330950728901424 no 2270 0.334106767658274 3260 6801262
SGTC_2709 st078560 56 µM -0.428612640954113 0.330946501516811 no 2271 0.334102572330637 3313 17250903
SGTC_2737 bleomycin 30.5 nM -0.428965082427719 0.330817267393217 no 2272 0.333974317891736 3225 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2485 5633444 17.78 µM -0.430602983033286 0.330216942657126 no 2273 0.333378535908338 3205 5724239
SGTC_111 0083-0039 52.457 µM -0.432255630904208 0.329611655408487 no 2274 0.332777815388228 3096 759313
SGTC_1374 2889-5571 141 µM -0.43333374136203 0.329217034510609 no 2275 0.332386164434487 3205 2853281
SGTC_2513 baicalein 25.65 µM -0.43380869324379 0.32904324814227 no 2276 0.332213684146695 3201 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2291 7917025 104.35 µM -0.435440853726942 0.328446317363362 no 2277 0.331621230938811 3118 2964612
SGTC_1271 0832-2808 169 µM -0.435577460933589 0.328396375775444 no 2278 0.331571663355582 3286 3663794
SGTC_2918 7977171 22.06 µM -0.435740201671388 0.328336884154528 no 2279 0.331512617135637 3192 2236483
SGTC_3199 9111318 49.47 µM -0.436352216983723 0.328113194372206 no 2280 0.331290600878802 3229 8548020
SGTC_660 4031-1742 102 µM -0.436705376807696 0.327984143540319 no 2281 0.331162514678012 3210 6738706
SGTC_1888 azatryptophan 97.5 µM -0.436802534316595 0.327948644073058 no 2282 0.331127280452628 3239 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_797 k781-0471 270 µM -0.437791147011698 0.327587512614868 no 2283 0.330768844563659 3173 23738129
SGTC_2652 actinonin 100 µM -0.438739906647239 0.327241090731483 no 2284 0.330425003823614 3143 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1780 st038448 24.544 µM -0.439007182717345 0.327143526702973 no 2285 0.330328165912153 3329 728868 YDL195W SEC31
SGTC_2427 5545055 42.75 µM -0.439514210298258 0.326958478418642 no 2286 0.330144493852907 3169 5372858
SGTC_1353 1498-1206 8.11 µM -0.439853117614325 0.326834812184404 no 2287 0.330021746614733 3260 6756808
SGTC_2181 6316240 54.2555 µM -0.441755113614191 0.326141132904818 no 2288 0.329333211477619 3256 12779990
SGTC_2179 6298986 200 µM -0.44338376452347 0.325547623249554 no 2289 0.328744088582819 3284 738374
SGTC_2640 pentamidine 10.38 µM -0.444184997117262 0.325255801820133 no 2290 0.328454419134016 3267 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2055 5235184 200 µM -0.44431036117194 0.325210151960505 no 2291 0.328409105615595 3312 2836034
SGTC_2906 7926292 26.41 µM -0.444374658034793 0.325186740024775 no 2292 0.328385866144471 3293 2966319
SGTC_1951 sophoraflavanone G 9.2 µM -0.444652516346107 0.325085573491922 no 2293 0.328285444615943 3173 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_410 α-linolenic acid 100 µM -0.446724298165183 0.324331657157707 no 2294 0.327537067854108 3311 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_559 1550-0661 158 µM -0.447005424743489 0.324229411261459 no 2295 0.32743557154986 3265 5830875
SGTC_1257 0669-0121 16 µM -0.447961469914998 0.323881796304809 no 2296 0.327090502037793 3241 4307855
SGTC_1427 4048-4900 550 nM -0.448889935287363 0.323544356229758 no 2297 0.326755528439166 3297 24132586
SGTC_2722 naftopidil 47.16 µM -0.448904192531617 0.323539175728206 no 2298 0.326750385769545 3300 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2249 haloperidol 116.36 µM -0.450345420210274 0.323015668944363 no 2299 0.326230696669384 3236 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_981 1488-1094 54.9 µM -0.452905013819663 0.322086794852937 no 2300 0.325308570221178 3206 3449522
SGTC_2116 5511452 16.8835 µM -0.454467606385671 0.321520276851406 no 2301 0.324746151080347 3315 870744
SGTC_2848 9016370 25.97 µM -0.455293344310416 0.321221072978321 no 2302 0.324449106936089 3358 7894410
SGTC_2101 5377231 179.231 µM -0.455765578567972 0.321050012317975 no 2303 0.324279279458311 3301 2844213
SGTC_2312 7706453 155.7 µM -0.455807482093438 0.321034835149607 no 2304 0.324264211647267 3193 976098
SGTC_1522 st012842 45.6 µM -0.456164116633918 0.320905676677791 no 2305 0.324135983445959 3144 3491067 YOR116C RPO31
SGTC_566 0958-0068 16.5 µM -0.456738112161542 0.320697844441192 no 2306 0.323929646756238 3320 6815365
SGTC_757 1066-0008 322 µM -0.457136456117581 0.320553645130773 no 2307 0.323786484096577 3303 6842497
SGTC_2836 9010338 19.48 µM -0.462361058451869 0.318664868468806 no 2308 0.321911210069317 3198 2994051
SGTC_2193 5925765 200 µM -0.463287736811099 0.318330349057693 no 2309 0.321579067347024 3295 877370
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.465564671622337 0.31750903315972 no 2310 0.320763567785641 3219 6708784 An antioxidant flavonoid
SGTC_1902 st060212 70.5 µM -0.467114621374145 0.316950462037035 no 2311 0.320208936886053 3344 688944
SGTC_1736 st036774 51 µM -0.467840132551353 0.316689145381712 no 2312 0.319949459286039 3422 1272247
SGTC_3089 9117425 49.47 µM -0.470732367819417 0.31564832194698 no 2313 0.318915933494839 3283 9401657
SGTC_2875 9039966 71.43 µM -0.471326821377748 0.315434577700957 no 2314 0.318703682479249 3267 6463691
SGTC_262 fenpropimorph 62.5 µM -0.47300154763863 0.314832738203647 no 2315 0.31810603751523 3276 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2289 7946404 165.07 µM -0.473008237304239 0.314830335150425 no 2316 0.318103651180646 3211 1246120 YPR165W RHO1
SGTC_298 1391-0729 10 µM -0.473124982968728 0.314788399182863 no 2317 0.318062006934205 3232 3237558
SGTC_1400 3771-8998 51.5 µM -0.475218977041836 0.314036625948698 no 2318 0.317315451141776 3230 670767
SGTC_1238 0333-0287 48.8 µM -0.479535355903833 0.31248942072246 no 2319 0.315778911023786 3262 7226
SGTC_1816 st051957 91.6 µM -0.479791002307015 0.312397887551537 no 2320 0.315688005721167 3286 674121
SGTC_1886 st057356 49.9 µM -0.481150977467073 0.311911148566103 no 2321 0.315204599694538 3225 24207747
SGTC_375 3970-0961 9.27 µM -0.482213028880445 0.311531265567881 no 2322 0.31482731114915 3267 2898222
SGTC_2426 5582046 32.21 µM -0.482968714582203 0.311261087972904 no 2323 0.31455897512271 3384 2251934
SGTC_1548 st061468 90.8 µM -0.484151865309525 0.310838284527949 no 2324 0.314139047482149 3310 390799
SGTC_3322 9139058 2.11 µM -0.486013130910849 0.310173659505425 no 2325 0.31347892802946 3386 4908926 YPR165W RHO1
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.486283536407789 0.31007715398186 no 2326 0.31338307519545 3236 688803
SGTC_2428 5615643 7.78 µM -0.48705206245393 0.309802944722307 no 2327 0.313110718352498 3328 2253075
SGTC_880 0833-0487 87.2 µM -0.487262263702863 0.309727963563537 no 2328 0.313036243180007 3279 76075
SGTC_1588 farnesol 29.9 µM -0.487725138732903 0.309562878727664 no 2329 0.312872271536118 3288 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_188 3229-0966 278.469 µM -0.48830160821097 0.309357334035227 no 2330 0.312668111265698 3382 5722370
SGTC_2449 5812982 45.77 µM -0.488754068307065 0.309196047625437 no 2331 0.312507909940019 3334 776185
SGTC_15 0266-0086 27.098 µM -0.488840606885163 0.309165203796135 no 2332 0.312477273493834 3375 1712902 YIL048W NEO1
SGTC_1911 st060208 74.3 µM -0.488864477241424 0.30915669622957 no 2333 0.312468823122138 3321 688783
SGTC_1292 0kpi-0043 232 µM -0.488928212236308 0.309133981120663 no 2334 0.312446260707997 3304 3333905
SGTC_1194 1488-0194 225 µM -0.489279921915211 0.309008645154812 no 2335 0.312321766881526 3230 1391452
SGTC_1208 2323-2347 50.3 µM -0.490021489397814 0.308744451548763 no 2336 0.31205934624264 3372 5412760
SGTC_1714 st033236 13.627 µM -0.490881672604103 0.308438123418182 no 2337 0.311755070157564 3432 2916566
SGTC_2533 agelasine 13.65 µM -0.49181808547593 0.308104799958491 no 2338 0.311423975082868 3454 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1799 st045822 46.1415 µM -0.493228568058711 0.307603026370867 no 2339 0.310925547169226 3369 3674992
SGTC_1769 st044406 64.4 µM -0.493429724447418 0.307531495071878 no 2340 0.31085449195066 3250 670903
SGTC_1284 0929-0043 16 µM -0.493954565637307 0.307344895778485 no 2341 0.310669133557291 3300 1239883
SGTC_2403 6032726 181.2 µM -0.49590793587751 0.306650843134 no 2342 0.30997968342974 3297 2881040
SGTC_2784 7567673 72.73 µM -0.496883394522491 0.306304511769296 no 2343 0.309635641040539 3388 3471247
SGTC_585 0kpi-0023 191 µM -0.498824644840914 0.305615796142015 no 2344 0.308951462043659 3343 64601
SGTC_288 1315-0019 35.1 µM -0.499284950218478 0.30545258997026 no 2345 0.308789327947291 3385 6811474
SGTC_810 3825-7150 143 µM -0.499855698838367 0.30525027865339 no 2346 0.308588343994226 3415 22330411 YGL099W LSG1
SGTC_3285 9112818 20.8695 µM -0.50016578988358 0.305140386671159 no 2347 0.308479172275893 3336 17017947 YPR165W RHO1
SGTC_412 gemfibrozil 100 µM -0.502897435341556 0.304173089067364 no 2348 0.307518192183415 3360 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2404 5161160 200 µM -0.504873052342708 0.303474359703667 no 2349 0.306824001133856 3332 2831543
SGTC_1161 k007-0610 110 µM -0.507669994992318 0.302486374820667 no 2350 0.305842397117246 3437 5843850
SGTC_1268 0828-0275 2.46 µM -0.510231610477017 0.301582783614146 no 2351 0.304944604420628 3377 745337
SGTC_61 0978-8327 98.565 µM -0.510657093102224 0.301432815382038 no 2352 0.304795595100314 3395 6150059 YHR072W ERG7
SGTC_244 nsc-207895 1.295 µM -0.510810321914014 0.301378815631097 no 2353 0.304741940387322 3276 42640
SGTC_14 0354-0009 295 µM -0.512954533004908 0.30062362614092 no 2354 0.303991562830042 3325 1713507
SGTC_365 0121-0052 13.6 µM -0.513306131973614 0.300499874824006 no 2355 0.303868597637654 3393 3101739
SGTC_897 1000-0139 31.4 µM -0.513486676080105 0.300436338155702 no 2356 0.303805464320415 3404 6151020
SGTC_251 melphalan 456.522 µM -0.514765083262502 0.299986617763475 no 2357 0.3033585937952 3364 460612 A DNA alkylator.
SGTC_1519 esterone 74 µM -0.515634477675957 0.299680954747406 no 2358 0.303054862646891 3248 698 A steroid.
SGTC_1640 st009078 66.4 µM -0.515944832307786 0.299571873973453 no 2359 0.302946470287952 3385 690618
SGTC_1946 st076057 65.1 µM -0.516056815074925 0.299532519652496 no 2360 0.302907364204729 3313 953009
SGTC_77 0828-0286 12.516 µM -0.516229004196859 0.299472011467616 no 2361 0.302847237556996 3387 745345
SGTC_1633 st005664 67.9 µM -0.516421507814467 0.299404371220805 no 2362 0.302780023626372 3283 2063822
SGTC_2870 9038528 12.99 µM -0.517571719642202 0.299000364233235 no 2363 0.302378558737562 3408 6463316
SGTC_827 3253-0474 693 µM -0.517868955117156 0.298896001811196 no 2364 0.302274851805542 3420 5402065
SGTC_1641 st009299 47.1 µM -0.518002769261833 0.298849023695943 no 2365 0.302228168596773 3374 4046054
SGTC_43 0570-0105 72.5 µM -0.519206005325423 0.298426754558633 no 2366 0.301808545846819 3361 1114046 YDL195W SEC31
SGTC_371 0195-0006 7.36 µM -0.522329810511182 0.297331741749386 no 2367 0.300720358385026 3309 3928593
SGTC_1385 3091-4834 14.1 µM -0.523756110703067 0.296832380326505 no 2368 0.300224091663124 3375 4072814
SGTC_2793 7325131 81.82 µM -0.525283929164469 0.296297902594005 no 2369 0.299692913799274 3316 4176441
SGTC_2311 7694451 200 µM -0.527149244807018 0.295645956998099 no 2370 0.299044975822545 3318 2163142
SGTC_818 4072-2707 53.5 µM -0.527473153091673 0.295532815186725 no 2371 0.298932527549918 3321 882871
SGTC_2885 9057732 51.95 µM -0.52999605377818 0.294652243220251 no 2372 0.298057333424033 3449 6471414
SGTC_588 3970-1144 52.9 µM -0.530559535308413 0.29445573584298 no 2373 0.29786202133346 3390 1888707
SGTC_2698 st077697 67.5 µM -0.531102319426165 0.294266503658732 no 2374 0.297673938515116 3328 3154499
SGTC_1979 st071809 45.3 µM -0.531839900050182 0.294009449147438 no 2375 0.297418442686481 3447 4976333
SGTC_1114 scopoletin 1.73284 µM -0.532108751843246 0.293915777327352 no 2376 0.297325338104802 3443 5280460 A coumarin with genotoxic properties.
SGTC_2196 6573537 42.6665 µM -0.533199333182125 0.293535944771599 no 2377 0.296947801534766 3451 2903087
SGTC_2304 7443016 91.4 µM -0.533792474061329 0.293329458488681 no 2378 0.296742560625191 3371 939854
SGTC_1988 st071872 53.4 µM -0.534271252040913 0.293162833732043 no 2379 0.29657693939649 3447 16414116
SGTC_363 0455-0021 3.06 µM -0.536974849420211 0.292222749980758 no 2380 0.295642493479705 3415 4597466
SGTC_2628 lathosterol 100 µM -0.538562903073742 0.291671213137235 no 2381 0.295094245261091 3463 6710616
SGTC_712 r015-0009 80.6 µM -0.539329151844244 0.291405265792119 no 2382 0.294829878622595 3424 6813872 YLR060W FRS1
SGTC_3076 9116187 49.47 µM -0.539847841077986 0.291225304911706 no 2383 0.294650985506447 3386 27241210
SGTC_1814 st052110 31.539 µM -0.540311054749073 0.291064635324446 no 2384 0.294491267947989 3441 674163
SGTC_393 acivicin 6.25 µM -0.540559646897749 0.290978426107424 no 2385 0.294405569057661 3306 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2683 piperine 63.03 µM -0.541093042504529 0.290793490235565 no 2386 0.294221726768434 3347 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_297 0986-0032 24 µM -0.541869483015606 0.290524385489039 no 2387 0.293954210468687 3344 2847425
SGTC_1240 0356-0016 42.1 µM -0.542801192254066 0.290201620425545 no 2388 0.293633346127028 3354 4305613
SGTC_3316 9136639 10.545 µM -0.543394040803907 0.289996331833054 no 2389 0.293429263914397 3439 4903665
SGTC_639 0833-0042 114 µM -0.543968104379866 0.289797612912747 no 2390 0.293231710884823 3347 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1962 st076595 64.5 µM -0.544683215290947 0.289550158179882 no 2391 0.292985705385445 3384 279619
SGTC_1770 st043884 66.3 µM -0.544968988739542 0.289451297787868 no 2392 0.292887423170664 3438 670149
SGTC_2019 4016004 108 µM -0.545822686613973 0.28915606423348 no 2393 0.292593913528884 3370 45595336
SGTC_1141 3253-0389 52.6 µM -0.549027060789398 0.28804916351945 no 2394 0.291493439549633 3433 5402031
SGTC_808 0711-0032 135 µM -0.549378839991914 0.287927768848456 no 2395 0.291372746174923 3423 4252555
SGTC_2881 9058953 51.95 µM -0.549711430180535 0.287813018290303 no 2396 0.291258657887114 3362 17122249
SGTC_1117 retinoic acid 1.10837 µM -0.551082370158344 0.287340243565008 no 2397 0.290788605130232 3478 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_555 4296-0685 37 µM -0.552668901661487 0.286793580218028 no 2398 0.290245075891115 3413 2908540 YHR072W ERG7
SGTC_46 0329-0187a 2.197 µM -0.553597017578156 0.286474012596 no 2399 0.289927333792984 3409 46494817
SGTC_2302 7771753 200 µM -0.554589285288439 0.286132543315449 no 2400 0.289587809748319 3421 2203047
SGTC_2275 7947463 200 µM -0.555283458096634 0.285893772499492 no 2401 0.289350395808948 3435 1225414
SGTC_1308 1187-1617 41.4 µM -0.555734358031558 0.285738729687065 no 2402 0.289196232601699 3427 2882570
SGTC_1478 0453-0656 35.7 µM -0.555772485596308 0.285725621284576 no 2403 0.289183198514231 3470 5258496
SGTC_753 1322-0200 289 µM -0.555806490543915 0.285713930494963 no 2404 0.289171573995849 3488 5403907
SGTC_2617 dihydrotanshinone i 20.83 µM -0.55593874414865 0.285668464302504 no 2405 0.289126365473786 3387 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2971 9092186 9.93 µM -0.556188220123649 0.285582708733448 no 2406 0.28904109563647 3324 25236400
SGTC_2967 9089538 49.85 µM -0.556720786077325 0.285399684028988 no 2407 0.288859106426724 3494 728216
SGTC_133 0724-0033 378.92 µM -0.557278858269442 0.285207953659996 no 2408 0.28866845907652 3333 280309
SGTC_2457 5731572 11.68 µM -0.558964937038046 0.284629060350539 no 2409 0.288092824976622 3465 2865357
SGTC_2382 9035899 200 µM -0.559427031830123 0.284470504088842 no 2410 0.287935158572621 3419 6462679
SGTC_648 0375-0473 33.3 µM -0.560109941030047 0.284236258174375 no 2411 0.287702225078008 3435 1713139
SGTC_737 1950-0117 57.9 µM -0.560328845433162 0.284161190903076 no 2412 0.287627577826853 3464 5393513
SGTC_2119 5528445 120.635 µM -0.560853399120333 0.283981348166621 no 2413 0.287448740243727 3473 791935
SGTC_598 3937-0236 20.2 µM -0.562308139080103 0.283482877099353 no 2414 0.286953046953915 3463 1379313
SGTC_1802 st050112 57.9 µM -0.562750074539708 0.283331529662359 no 2415 0.286802540522693 3435 4662563
SGTC_1032 k061-1018 98.7 µM -0.564226349424774 0.282826238240803 no 2416 0.286300048810517 3531 4005393
SGTC_1681 tripelennamine 100 µM -0.564840863903585 0.282616033193436 no 2417 0.286091004790848 3468 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_3040 9091894 49.47 µM -0.568485616220792 0.281370830105916 no 2418 0.284852634926799 3401 25236966
SGTC_1953 st076800 12.1 µM -0.571568082060348 0.280319799033375 no 2419 0.283807312093492 3400 297591
SGTC_3102 9121669 49.47 µM -0.571975439404049 0.280181044410416 no 2420 0.28366930697382 3410 41905072
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.572258583517594 0.280084619077928 no 2421 0.283573401934294 3500 364106
SGTC_1975 st070967 30.8 µM -0.573217787920569 0.279758079558017 no 2422 0.283248620930635 3503 261391
SGTC_302 1094-0063 18.9 µM -0.574791641543813 0.279222697069418 no 2423 0.282716110162458 3399 5440289
SGTC_2356 9061756 188.97 µM -0.575758789792668 0.278893946575032 no 2424 0.282389115958591 3433 20104043
SGTC_2361 9034121 116 µM -0.576207211126297 0.278741584299334 no 2425 0.282237565819684 3416 6496917
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.57863824660762 0.277916285659029 no 2426 0.281416646061235 3362 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2805 7950783 58.44 µM -0.579287935074743 0.277695928684417 no 2427 0.281197452475723 3468 1178958 YDL195W SEC31
SGTC_2332 7982454 138.89 µM -0.579672365558247 0.277565580332462 no 2428 0.28106779115628 3479 2981748
SGTC_687 k029-0044 34.9 µM -0.580271500627108 0.277362491996463 no 2429 0.280865771540893 3506 5829338
SGTC_186 3455-3465 67.277 µM -0.580545728323325 0.27726956149744 no 2430 0.280773329380654 3456 755278
SGTC_37 0566-0070 1.56 µM -0.581614255032434 0.27690760366367 no 2431 0.280413269436836 3455 1626686
SGTC_815 1582-0027 36.9 µM -0.584801339061426 0.275829371872731 no 2432 0.279340651938356 3500 3128206
SGTC_2025 5147754 141 µM -0.584879730630992 0.275802877006461 no 2433 0.27931429428635 3481 315777 YLR208W SEC13
SGTC_513 4245-1575 41.7 µM -0.585205178466342 0.275692895175158 no 2434 0.279204881658034 3457 719745
SGTC_3253 9135987 49.47 µM -0.58598785372914 0.275428486222225 no 2435 0.278941838613677 3485 4182430
SGTC_2374 9071832 200 µM -0.588016307452761 0.274743800698938 no 2436 0.278260673521822 3483 17381698
SGTC_1455 4262-0120 131 µM -0.588113683859503 0.274710953328308 no 2437 0.278227994439211 3578 1529587
SGTC_3158 9100007 49.47 µM -0.588226888036729 0.274672769309792 no 2438 0.2781900059807 3432 19297233
SGTC_899 1083-0020 478 µM -0.588556812469628 0.274561500003772 no 2439 0.278079306116151 3546 767123
SGTC_998 3996-0085 177 µM -0.588788800920336 0.274483273605488 no 2440 0.278001479676272 3465 715391
SGTC_44 0929-0055 61.211 µM -0.588865788730323 0.274457315782315 no 2441 0.277975654501758 3409 1379590
SGTC_1370 2001-0092 44.6 µM -0.589351425696429 0.274293602483553 no 2442 0.277812777007986 3608 790957
SGTC_3078 9116413 49.47 µM -0.589957327382553 0.274089414320541 no 2443 0.277609629358157 3429 17177322
SGTC_2281 7943571 200 µM -0.590256337799606 0.27398867584079 no 2444 0.277509403437954 3561 1244024
SGTC_3314 9135860 59.4275 µM -0.59057575767735 0.273881081505113 no 2445 0.277402355968291 3512 25252478
SGTC_1604 st002052 72.4 µM -0.591128324001608 0.2736950027696 no 2446 0.277217221602777 3552 6254834 YHR062C RPP1
SGTC_1677 st019204 53.9 µM -0.591955220596739 0.273416659182878 no 2447 0.276940287310742 3467 3945625
SGTC_896 0964-0007 44.5 µM -0.592232833550434 0.273323242676125 no 2448 0.276847342890103 3497 6756758
SGTC_1127 asiatic acid 681.4 nM -0.592865625586932 0.273110367828979 no 2449 0.276635542136115 3446 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.594495883339519 0.272562318641298 no 2450 0.276090247433261 3528 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1565 sinapyl alcohol 95.1 µM -0.594830110382882 0.272450027898969 no 2451 0.275978519141612 3498 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2469 5655019 90.81 µM -0.595065201036581 0.272371057918334 no 2452 0.275899944320269 3557 2788239
SGTC_2812 7970281 58.44 µM -0.59719201260229 0.271657151645964 no 2453 0.275189595669404 3554 2233435
SGTC_2089 5281248 129.67 µM -0.597811734741975 0.27144930509158 no 2454 0.274982779893036 3533 2737878
SGTC_2142 5622915 118.518 µM -0.598481574481297 0.271224738888268 no 2455 0.27475932485241 3482 5322196
SGTC_458 nppb 133 µM -0.600052986174948 0.270698281169894 no 2456 0.274235461733635 3586 4549 A chloride channel blocker.
SGTC_744 1594-0068 283 µM -0.600226741991001 0.270640100468459 no 2457 0.274177566880094 3522 668392
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.600620241744821 0.270508363413137 no 2458 0.27404647640687 3490 6708739 YPR165W RHO1
SGTC_482 fipronil 114 µM -0.601561921383919 0.270193235144913 no 2459 0.27373289113274 3545 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1916 st067606 49.2 µM -0.602081864393264 0.270019317585986 no 2460 0.273559822909217 3489 19590279
SGTC_1550 gossypolone 36.6 µM -0.603259639409188 0.269625566765919 no 2461 0.27316798910926 3532 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3321 9137793 26.8275 µM -0.603466734341759 0.269556361051192 no 2462 0.273099119486112 3522 4904192
SGTC_3246 9135460 32.98 µM -0.604030149506046 0.269368127486361 no 2463 0.272911798782863 3478 41446951
SGTC_1959 st077091 55.8 µM -0.604437432933842 0.269232097633608 no 2464 0.272776427458822 3517 821356 YKL052C ASK1
SGTC_2756 carbadox 75.1 µM -0.606140630564162 0.268663614980717 no 2465 0.272210686272016 3499 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1832 st054113 55 µM -0.606761962668653 0.268456380887754 no 2466 0.272004447291112 3532 1251267
SGTC_2029 5175081 200 µM -0.608863534447298 0.267756035796607 no 2467 0.271307448280076 3522 1380876
SGTC_121 0557-0495 61.343 µM -0.609729879524786 0.267467596036668 no 2468 0.2710203790201 3597 3104427
SGTC_852 0418-0143 439 µM -0.609800682531051 0.267444029907827 no 2469 0.270996924667752 3554 5369229
SGTC_342 k048-0088 23.3 µM -0.610477841990955 0.267218696530508 no 2470 0.270772658570876 3492 6820570
SGTC_2271 7849410 118.62 µM -0.610539062339603 0.267198329408886 no 2471 0.270752387783378 3538 972430
SGTC_2591 skatole 100 µM -0.610945049437597 0.267063283222309 no 2472 0.270617979788257 3535 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_960 1222-0186 7.7 µM -0.611225196449746 0.266970116159777 no 2473 0.270525252438909 3538 3126296
SGTC_1650 st011916 45.8 µM -0.612158930250343 0.266659707659521 no 2474 0.2702163055933 3545 242528
SGTC_2434 5670830 169.91 µM -0.612161703132911 0.266658786120075 no 2475 0.270215388385518 3516 1549830
SGTC_2857 9024691 58.44 µM -0.613309497377403 0.266277466644486 no 2476 0.269835857375668 3532 16478292
SGTC_2585 alliin 100 µM -0.613698854144498 0.266148177504692 no 2477 0.269707172854287 3626 87310 A garlic compound which reacts with lipids.
SGTC_2391 6285546 200 µM -0.614329099859808 0.265938966582002 no 2478 0.269498938397256 3451 846083
SGTC_2569 tetrandrine 100 µM -0.614656330310419 0.265830374859823 no 2479 0.269390852583851 3463 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2482 5981709 142.65 µM -0.616109582265681 0.265348383557143 no 2480 0.268911099111499 3500 877755
SGTC_1217 1183-1422 255 µM -0.616969809925537 0.265063286179286 no 2481 0.268627319499099 3556 2849664
SGTC_936 3005-4620 401 µM -0.61737152763558 0.264930201877325 no 2482 0.268494848827625 3574 777207
SGTC_2780 5215298 71.43 µM -0.617411772020844 0.264916871262477 no 2483 0.268481579625243 3563 2834131
SGTC_2707 st078556 66.6 µM -0.617716152734068 0.264816058746401 no 2484 0.268381231227884 3503 17250899
SGTC_1045 1348-1485 165 µM -0.619892364228653 0.264095854528438 no 2485 0.267664326620735 3570 6810614
SGTC_3308 9128332 17.569 µM -0.61994254106569 0.264079260580546 no 2486 0.267647808365466 3563 17332805 YDL196W YDL196W
SGTC_2398 5228213 48.84 µM -0.620643208812935 0.263847598737616 no 2487 0.267417201671971 3578 80771 YMR134W ERG29
SGTC_2348 9022543 33.42 µM -0.622482293640313 0.263240035235166 no 2488 0.266812391523924 3566 3162678 YDL140C RPO21
SGTC_2052 5265182 7.135 µM -0.622520783689832 0.263227327228969 no 2489 0.266799740892387 3539 1239884
SGTC_1155 4088-0394 48.2 µM -0.623050268588804 0.263052542497711 no 2490 0.266625744389774 3500 2326248
SGTC_1891 st059073 26.2 µM -0.62440472164644 0.262605703106502 no 2491 0.266180912502076 3591 688754
SGTC_2989 9073649 71.4286 µM -0.624486698868956 0.262578670969661 no 2492 0.266154001460267 3560 21367202
SGTC_491 tetrandrine 80.3 µM -0.625353702949082 0.262292862014646 no 2493 0.26586947037746 3554 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_768 0384-0033 77.3 µM -0.625560158375829 0.262224827228295 no 2494 0.265801739117371 3504 3965305 YMR134W ERG29
SGTC_965 1291-5240 308 µM -0.62728678971589 0.261656191806485 no 2495 0.26523563059591 3560 2834598
SGTC_173 1273-0061 2.693 µM -0.628242733404578 0.261341641076806 no 2496 0.264922469997139 3512 2847414 YPL266W DIM1
SGTC_2247 cerulenin 830 nM -0.628287088026826 0.261327051022819 no 2497 0.264907944289894 3625 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1096 rimcazole 32.2 µM -0.628844986380399 0.261143571113783 no 2498 0.264725272579212 3501 18528119 A dopamine reuptake inhibitor.
SGTC_2118 5526350 200 µM -0.629107307551928 0.261057322617063 no 2499 0.264639403348414 3544 743594
SGTC_472 calcifediol 10 µM -0.62935521320905 0.260975827253915 no 2500 0.264558265971068 3542 5283731 A vitamin D metabolite.
SGTC_3064 1327-0027 10 µM -0.63086202994709 0.260480764823714 no 2501 0.264065370287552 3468 16000455 YPR107C YTH1
SGTC_1315 1237-0019 3.69 µM -0.630898363408485 0.26046883349213 no 2502 0.264053491007936 3560 825140
SGTC_573 3702-0553 84.7 µM -0.631304148467348 0.260335599251127 no 2503 0.263920837480433 3560 1222756
SGTC_2126 5251174 33.877 µM -0.633061148018517 0.259759116722993 no 2504 0.263346856206522 3605 790722
SGTC_1128 3448-9350 235 µM -0.633456029292482 0.259629644434761 no 2505 0.263217943125037 3509 619386
SGTC_3226 9131256 49.47 µM -0.633837668240326 0.259504545659206 no 2506 0.26309338377647 3492 17178073
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.634393199322109 0.259322501820232 no 2507 0.262912123348131 3525 4620898
SGTC_1093 fluphenazine 7.97 µM -0.635051460135418 0.259106879580823 no 2508 0.262697426620391 3620 6602611 An atypical antipsychotic.
SGTC_1997 st073024 93.8 µM -0.635471404924505 0.25896936942878 no 2509 0.262560505339772 3569 686268
SGTC_405 ebelactone b 50 µM -0.636615421705472 0.258594954801284 no 2510 0.262187688719898 3554 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1798 st045719 60.953 µM -0.637301933433353 0.258370407399895 no 2511 0.261964095909859 3534 3980186
SGTC_2227 7312221 64.1025 µM -0.637493163004777 0.258307877150699 no 2512 0.261901830982746 3591 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2340 7987427 183.45 µM -0.638073791274701 0.258118065303064 no 2513 0.26171282317635 3539 2239331
SGTC_1084 voriconazole 435 nM -0.638810923244572 0.257877195424911 no 2514 0.261472970695468 3580 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3103 9120822 49.47 µM -0.639242905893106 0.257736092279868 no 2515 0.26133246202682 3663 17141819
SGTC_764 1951-2361 146 µM -0.639444019799314 0.257670413954078 no 2516 0.261267060024197 3533 5438930
SGTC_1618 st003135 44.5 µM -0.63950303646187 0.257651142368251 no 2517 0.261247869471894 3530 1270615
SGTC_587 k089-0003 57 µM -0.639585312890582 0.257624276675117 no 2518 0.261221116709082 3534 9659696
SGTC_3331 9141060 1.957 µM -0.642115027850085 0.256798960226539 no 2519 0.260399249570272 3555 4906567 YPR165W RHO1
SGTC_73 0327-0325 16.231 µM -0.642633924780275 0.256629840983881 no 2520 0.260230832368201 3623 53298
SGTC_1552 6-methylflavone 10.6 µM -0.64281444926113 0.256571017923553 no 2521 0.260172253110353 3563 689013
SGTC_2721 ifenprodil 61.44 µM -0.642997594735933 0.256511348001612 no 2522 0.260112830299679 3597 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_198 3454-2873 16.191 µM -0.643363580533964 0.256392129238862 no 2523 0.259994104650918 3557 710957
SGTC_508 roscovitine 141 µM -0.64343264978922 0.256369633377868 no 2524 0.259971701746769 3605 160355 A CDKinase inhibitor.
SGTC_2201 6605497 169.863 µM -0.64496600039839 0.255870486006442 no 2525 0.259474609515509 3581 670741
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.647124502617591 0.255168695246368 no 2526 0.258775684149993 3565 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_3092 9117248 49.47 µM -0.652688589561804 0.253364303871749 no 2527 0.25697853004218 3621 17141857
SGTC_2178 5812956 200 µM -0.6528885456257 0.25329958470317 no 2528 0.256914066961282 3588 5403383
SGTC_863 0466-0191 129 µM -0.653661972878265 0.253049333715314 no 2529 0.256664803905875 3600 765160 YPR165W RHO1
SGTC_1414 3917-0015 5.4 µM -0.654590880295627 0.252748947404462 no 2530 0.256365598644514 3585 6618702
SGTC_721 1187-1332 279 µM -0.655120788587543 0.252577671954813 no 2531 0.256194994259942 3539 25730
SGTC_1042 0350-0096 82 µM -0.655767750745044 0.252368645612527 no 2532 0.255986784576552 3601 3122515
SGTC_1846 st056244 14.8 µM -0.656953398495499 0.251985812696803 no 2533 0.255605440765061 3586 5393182
SGTC_3312 9133330 71.43 µM -0.658122090977421 0.251608754577113 no 2534 0.255229840911417 3629 17617324
SGTC_961 1252-1571 372 µM -0.658690041257974 0.251425623058209 no 2535 0.25504741464607 3615 6813498
SGTC_717 1532-0246 73.2 µM -0.658815484512703 0.251385184275266 no 2536 0.255007131330888 3591 9561992
SGTC_719 2810-4230 27.3 µM -0.659218266645392 0.25125536379706 no 2537 0.254877809301706 3592 721079
SGTC_949 1165-0505 146 µM -0.663100859898475 0.250005787421352 no 2538 0.253632979987147 3624 6244267
SGTC_2506 ethyl hematommate 54.16 µM -0.663138867943734 0.249993571206651 no 2539 0.25362080972625 3584 3940691 An allergen.
SGTC_3231 9132313 49.47 µM -0.663671838934581 0.249822301683565 no 2540 0.253450183538824 3613 4905967
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.663713312216538 0.249808976912021 no 2541 0.253436908745995 3617 5379071
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.665099633967107 0.249363788780254 no 2542 0.252993384381365 3583 688662
SGTC_1245 0418-0076 17.2 µM -0.665174396274172 0.249339792425437 no 2543 0.252969477372259 3621 6790114
SGTC_983 1491-0821 12.2 µM -0.665267871714754 0.249309791468922 no 2544 0.252939588070303 3595 46495113
SGTC_3326 9140064 16.379 µM -0.665805386672201 0.249137313217487 no 2545 0.252767750693628 3604 1868434
SGTC_1713 st033146 12.748 µM -0.666781240768335 0.248824342618762 no 2546 0.252455938476527 3636 674619
SGTC_3043 9092303 49.47 µM -0.668760994552848 0.24819005038551 no 2547 0.251823976007319 3580 25236084
SGTC_295 k015-0027 31 µM -0.671461316491964 0.247326287838568 no 2548 0.250963347365889 3607 3887424
SGTC_2243 6634756 200 µM -0.671516050518457 0.247308796483239 no 2549 0.250945919010267 3678 885676
SGTC_460 trequinsin 123 µM -0.673027244934478 0.246826125313057 no 2550 0.250464979044224 3667 5537 A vasodilator.
SGTC_2785 7756463 72.73 µM -0.67346930663928 0.246685027462675 no 2551 0.25032438462052 3623 2201551
SGTC_1605 st000082 49.1 µM -0.67374982792629 0.246595512707247 no 2552 0.2502351886244 3651 1114022
SGTC_2595 hexamethylquercetagetin 100 µM -0.674178065046116 0.246458895173588 no 2553 0.250099056649007 3569 386331
SGTC_3161 9100388 49.47 µM -0.675266066146145 0.246111980187043 no 2554 0.249753369578439 3674 25236368
SGTC_1064 honokiol 6.76 µM -0.675554518375591 0.246020049590483 no 2555 0.249661763152335 3633 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1688 st021091 57.6 µM -0.678232795434545 0.24516735495005 no 2556 0.24881205089466 3652 3656366
SGTC_2189 6047310 154.431 µM -0.679500489404131 0.244764308575153 no 2557 0.248410398819755 3591 711535
SGTC_2938 9059746 27.26 µM -0.679992089719529 0.244608106854099 no 2558 0.248254734799001 3612 6471769
SGTC_2292 7671323 168.05 µM -0.680254427589157 0.244524773253467 no 2559 0.24817168745179 3638 937504
SGTC_2838 9002687 71.43 µM -0.680439488341491 0.244465996512067 no 2560 0.248113112355013 3638 6457060
SGTC_2463 5473429 200 µM -0.680753559292994 0.244366262546782 no 2561 0.248013720062449 3618 5399405
SGTC_1908 st060353 56.5 µM -0.680788494279079 0.244355170215583 no 2562 0.248002665694217 3672 4227716
SGTC_1978 st071761 42 µM -0.683351611889052 0.243542086449922 no 2563 0.247192344135722 3621 5147680
SGTC_3302 9125395 16.351 µM -0.683986583612586 0.243340883933871 no 2564 0.246991818878846 3620 17599668
SGTC_2770 toltrazuril 17.5 µM -0.684218246828582 0.243267499537626 no 2565 0.246918680878654 3642 68591 Kills coccidiodes.
SGTC_1960 st011366 51.8 µM -0.684343096664228 0.243227955579508 no 2566 0.246879269556162 3666 3972846
SGTC_2930 9013230 14.89 µM -0.684555882851713 0.243160567359515 no 2567 0.246812107143161 3633 2995857
SGTC_825 1988-2224 89.6 µM -0.686303785060358 0.24260739853557 no 2568 0.24626078131139 3664 1180859
SGTC_2934 9036370 36.88 µM -0.68703349286585 0.242376665420517 no 2569 0.246030811341945 3664 6462800
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.687655896485712 0.242179955812291 no 2570 0.245834749744516 3616 756377
SGTC_806 3966-4455 5.86 µM -0.68811664147211 0.242034393906609 no 2571 0.245689665812317 3608 714982
SGTC_3030 9087619 49.47 µM -0.688950013976628 0.241771229375509 no 2572 0.245427362082512 3635 25236973
SGTC_1230 0170-0365 3.77 µM -0.689721488715089 0.241527749565204 no 2573 0.245184674853083 3746 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2671 danthron 100 µM -0.690236409394457 0.24136531313653 no 2574 0.245022765139858 3634 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1044 1222-0021 1.78 µM -0.690732600132554 0.241208841408878 no 2575 0.244866799232438 3641 4306703
SGTC_481 bay k-8644 50 µM -0.693896451379761 0.240212431584114 no 2576 0.243873574592503 3634 2303 A calcium channel antagonist.
SGTC_1857 st056007 79.3 µM -0.694487707499084 0.240026472983806 no 2577 0.243688203554523 3670 619834
SGTC_699 0375-0592 111 µM -0.69487343482201 0.239905198482086 no 2578 0.243567311066951 3694 762578
SGTC_684 1140-0066 328 µM -0.699353865467593 0.238498981393834 no 2579 0.242165455892132 3686 6813534
SGTC_2926 9010726 65.15 µM -0.700496030854589 0.238141227278252 no 2580 0.241808791531052 3672 2994293
SGTC_2321 7390090 138.78 µM -0.700802944385178 0.238045144608845 no 2581 0.241713000154947 3636 649046
SGTC_941 3237-0776 460 µM -0.703110302374601 0.237323481494619 no 2582 0.240993506127616 3677 760008
SGTC_1077 5-fluorocytosine 377 nM -0.703816461482215 0.237102859293673 no 2583 0.240773540418084 3686 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2508 celastrol 40.54 µM -0.703909692787879 0.237073739868461 no 2584 0.240744507409379 3643 122724 Celastrol is a natural product and antioxidant.
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.703975757548797 0.237053106703119 no 2585 0.240723935443413 3535 6708630 An antioxidant.
SGTC_1779 st039427 55 µM -0.704823521733256 0.236788422914796 no 2586 0.240460034310016 3720 1124498
SGTC_2075 5212009 200 µM -0.70494571325627 0.236750286424177 no 2587 0.240422010217247 3593 780898
SGTC_2465 5809242 33.21 µM -0.705429717327492 0.236599259904289 no 2588 0.240271427895456 3676 2731748
SGTC_645 0845-0943 5.41 µM -0.708134881417736 0.23575612912866 no 2589 0.239430750024093 3692 1885106
SGTC_643 k048-0106 28.4 µM -0.708756098385633 0.235562745789709 no 2590 0.239237922841978 3707 6763920
SGTC_1361 1608-0041 5.61 µM -0.710394534633311 0.23505312458125 no 2591 0.238729755704226 3666 X1361
SGTC_2009 4012297 12.05 µM -0.710594184566774 0.234991066879138 no 2592 0.238667873920634 3683 45595307
SGTC_1812 st052057 4.327 µM -0.710595037173248 0.234990801880688 no 2593 0.238667609672856 3702 3645418
SGTC_1000 4048-0884 8.67 µM -0.713376874835806 0.234127059123699 no 2594 0.237806289475793 3687 13040088
SGTC_3310 9130229 44.1445 µM -0.71365939875469 0.234039435706275 no 2595 0.23771890910954 3742 7761258
SGTC_479 n-linoleoylglycine 10 µM -0.713728493025524 0.234018009219248 no 2596 0.237697541979567 3723 6433346 An anti-infammatory.
SGTC_1524 corynanthine 62.1 µM -0.715185811973718 0.233566340381904 no 2597 0.237247117420844 3768 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_884 0851-0618 334 µM -0.716660994039978 0.233109627984208 no 2598 0.236791649649828 3719 9642473
SGTC_3233 9132340 49.47 µM -0.717329756595526 0.232902744350849 no 2599 0.236585325320211 3699 17682950
SGTC_2418 pentamidine 31.67 µM -0.717649530939656 0.232803857287505 no 2600 0.236486704604038 3681 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_560 2332-1943 155 µM -0.718879650335018 0.232423672562329 no 2601 0.23610753790852 3694 21177716
SGTC_2239 6685329 187.64 µM -0.719039337072917 0.232374344592377 no 2602 0.236058341329084 3726 805680
SGTC_1351 1496-0003 46.5 µM -0.72017519795816 0.232023640008713 no 2603 0.235708566268876 3721 3891978
SGTC_99 0109-0120 622.8 µM -0.720629480400269 0.231883459832253 no 2604 0.235568755365239 3742 759414
SGTC_1898 st060199 18.6 µM -0.720840947356925 0.231818222521905 no 2605 0.235503689465749 3723 688866
SGTC_666 0272-0154 136 µM -0.72087662407582 0.231807217303626 no 2606 0.235492713135964 3739 6870312
SGTC_1172 0370-0043 85 µM -0.721167871956496 0.231717386786883 no 2607 0.235403118123655 3729 376585
SGTC_499 genistein 192 µM -0.722994139938374 0.231154547468196 no 2608 0.234841742231821 3717 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2809 7964133 12.99 µM -0.723209547637546 0.231088211091223 no 2609 0.234775576953062 3746 1253665
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.72341877654959 0.231023787689961 no 2610 0.234711319436713 3718 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1413 3910-0535 34.4 µM -0.724880036173085 0.230574132756663 no 2611 0.234262814655598 3715 2876951
SGTC_170 4197-0004 226 µM -0.725031086633932 0.230527679817101 no 2612 0.23421647977018 3724 218692
SGTC_1930 st074634 34.3 µM -0.726271409980216 0.230146437837803 no 2613 0.233836201240488 3661 684253 YOR116C RPO31
SGTC_3143 9086658 49.47 µM -0.72723428250874 0.229850720120633 no 2614 0.233541224168068 3790 25236626
SGTC_831 k061-1017 217 µM -0.727763912428324 0.229688150741894 no 2615 0.233379059467233 3775 1240153
SGTC_123 0083-0120 66.675 µM -0.729283958211604 0.22922193202673 no 2616 0.232913991484923 3693 16001701
SGTC_1887 st057648 70.8 µM -0.730161399066723 0.228953050735522 no 2617 0.232645767228197 3748 688672
SGTC_2256 7954252 200 µM -0.730417394218859 0.228874637435293 no 2618 0.232567544623264 3680 2972920
SGTC_1878 temozolomide 1 mM -0.730430008408554 0.228870774000858 no 2619 0.232563690573733 3662 5394 DNA alkylating agent.
SGTC_2355 9061122 103.12 µM -0.731455409254587 0.228556839894078 no 2620 0.232250515708621 3744 5302957
SGTC_1710 st031758 61.5 µM -0.732622144839618 0.22819992946731 no 2621 0.231894460398294 3750 5394341
SGTC_2627 acetyl isogambogic acid 100 µM -0.732628892386551 0.228197866269654 no 2622 0.231892402118849 3710 6857789 A caspase activator and apoptosis inducer.
SGTC_1926 methyl fluorone black 53.6 µM -0.732681915963246 0.228181653613806 no 2623 0.231876228100421 3562 72721 Reacts with homocysteine.
SGTC_2735 sertaconazole 140 nM -0.733067786385669 0.228063688164574 no 2624 0.231758543247929 3789 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_76 0433-0009 400.328 µM -0.733438084013247 0.22795051577184 no 2625 0.231645639167575 3797 2841569
SGTC_2441 5730946 39.09 µM -0.736110851967621 0.227134587380077 no 2626 0.230831619545159 3788 1774275
SGTC_312 4092-0653 6.84 µM -0.736197113589292 0.227108281344298 no 2627 0.23080537429794 3722 1148278
SGTC_647 0140-0236 81 µM -0.736236915675912 0.227096144021355 no 2628 0.230793265006337 3734 990837
SGTC_2781 5567276 71.43 µM -0.736326737935204 0.227068754797007 no 2629 0.230765939001053 3765 2853274
SGTC_3115 9123671 49.47 µM -0.737433039238997 0.226731566524797 no 2630 0.230429524837694 3810 3286988
SGTC_1865 st057639 52.2 µM -0.737634103686972 0.226670314684198 no 2631 0.230368412787054 3729 688818
SGTC_1391 3442-0225 151 µM -0.7418265888206 0.225395254478737 no 2632 0.229096204357308 3704 5227075
SGTC_1046 2001-0062 216 µM -0.744831817324656 0.224483778779052 no 2633 0.2281866988696 3672 739778
SGTC_1369 1866-0067 208 µM -0.74715897261952 0.223779399675312 no 2634 0.227483803041273 3752 3531355
SGTC_1024 4507-0395 26 µM -0.748581355282856 0.223349494858488 no 2635 0.227054786611966 3791 4201836
SGTC_183 3914-0051 30.55 µM -0.75013420764084 0.222880693599326 no 2636 0.226586939466581 3755 1596232
SGTC_2825 7998094 58.44 µM -0.752216661524728 0.222252888159831 no 2637 0.225960387730475 3753 2987815
SGTC_1067 clotrimazole 1.36 µM -0.752530928631106 0.222158232542632 no 2638 0.225865918745169 3783 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1983 st071813 46.9 µM -0.754307575173612 0.221623548736841 no 2639 0.225332277372346 3816 11838595
SGTC_3300 9124615 50.48 µM -0.754663523198356 0.221516514269015 no 2640 0.225225449169331 3783 24824903
SGTC_1817 st052116 64.4 µM -0.75825031715015 0.220439606677626 no 2641 0.224150571934067 3757 4361398
SGTC_2974 9094440 9.66 µM -0.758524345418386 0.220357455337065 no 2642 0.224068572113164 3848 25236134
SGTC_152 4469-0003 551.229 µM -0.759921080200617 0.219938998947163 no 2643 0.223650880095256 3716 697280
SGTC_930 2810-3379 265 µM -0.760624431767989 0.219728450257811 no 2644 0.223440711301218 3787 1015764
SGTC_2094 5332512 191.667 µM -0.760637018115184 0.21972468358189 no 2645 0.223436951392848 3819 755774
SGTC_2653 dihydrofissinolide 100 µM -0.761430121405951 0.219487408871038 no 2646 0.223200100955724 3818 6857746
SGTC_2396 5342950 42.78 µM -0.762556033912868 0.219150819720142 no 2647 0.222864106781039 3794 1886677
SGTC_3265 9137266 49.47 µM -0.763993919176789 0.218721398776547 no 2648 0.222435433162952 3704 17224265
SGTC_296 1222-0039 74.9 µM -0.765868865548233 0.218162178702522 no 2649 0.221877166507933 3753 5984176
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.766359450059241 0.218015993464379 no 2650 0.221731226800875 3825 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3173 9105693 49.47 µM -0.767257152393838 0.217748640805388 no 2651 0.221464319207853 3814 17096658
SGTC_386 1509-0011 3.07 µM -0.767316467544734 0.217730982300404 no 2652 0.221446689918062 3820 3107280
SGTC_182 3448-4371 550.524 µM -0.769659395794952 0.217034138457036 no 2653 0.220750981009804 3760 3491403
SGTC_3215 9129942 49.47 µM -0.77175070326185 0.216413222805136 no 2654 0.220131047030277 3727 17682944
SGTC_3028 9087778 49.47 µM -0.772550680298516 0.216175979267964 no 2655 0.219894171187505 3776 17217395
SGTC_1838 st055369 84.5 µM -0.773015500394783 0.216038200061137 no 2656 0.219756603639901 3775 676036
SGTC_2264 7948757 110.76 µM -0.774477070671659 0.215605301677558 no 2657 0.219324361282808 3777 2971411
SGTC_1955 wogonin 32.4 µM -0.774738744513174 0.215527850363047 no 2658 0.219247025898107 3859 5281703 A flavanone.
SGTC_2916 7875993 68.79 µM -0.775599933621979 0.215273065989795 no 2659 0.21899261979504 3741 1299250
SGTC_2810 7959871 45.46 µM -0.776610477457202 0.214974317751333 no 2660 0.218694309047408 3802 2974535
SGTC_1215 3852-0577 11.2 µM -0.778249675819596 0.214490232033235 no 2661 0.218210918333383 3873 2884876
SGTC_293 4049-0273 38.5 µM -0.779236124512596 0.214199221134393 no 2662 0.217920316949424 3687 1380311
SGTC_2582 agaric acid 100 µM -0.780208848654293 0.213912484170165 no 2663 0.217633977382886 3665 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2839 9003951 25.97 µM -0.780734214390548 0.21375771128323 no 2664 0.217479416479231 3817 2990634
SGTC_3344 9148862 3.898 µM -0.781639995826219 0.213491021045303 no 2665 0.21721308735773 3808 4905352
SGTC_2103 5378138 10 µM -0.781690324443324 0.213476208423262 no 2666 0.217198294638743 3834 244142
SGTC_2723 salbutamol 83.58 µM -0.784441852916033 0.212667295788171 no 2667 0.216390444200932 3771 9884233 β2-adrenoceptor agonist
SGTC_2251 lansoprazole 556 µM -0.784503282016215 0.212649256902236 no 2668 0.216372428448156 3731 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1575 cyproterone acetate 48 µM -0.784529537464842 0.212641547163726 no 2669 0.216364728589268 3823 9880 An androgen receptor antagonist and liver toxin.
SGTC_1561 5-methoxyflavone 52.9 µM -0.784822193409825 0.212555621735346 no 2670 0.21627891297037 3756 94525
SGTC_848 0368-0089 85.6 µM -0.78550589644765 0.212354961735399 no 2671 0.216078507264998 3808 762535
SGTC_2124 5246320 200 µM -0.786766492010391 0.211985279896635 no 2672 0.215709286058261 3828 579342
SGTC_668 1682-0499 62.6 µM -0.787422863128506 0.211792941830642 no 2673 0.215517183612375 3829 682214
SGTC_600 1495-0418 41.6 µM -0.788451569298525 0.211491703014941 no 2674 0.215216308259862 3810 5377768
SGTC_406 estrone 100 µM -0.788477702866345 0.211484053520632 no 2675 0.215208667906628 3795 5870 A steroid.
SGTC_1333 1482-0047 286 µM -0.788685992827538 0.211423091254556 no 2676 0.215147778333085 3776 3811116
SGTC_855 0428-0020 25 µM -0.789111700212801 0.21129852731514 no 2677 0.21502336205928 3823 6812414
SGTC_1941 st076221 61.8 µM -0.790523449570156 0.210885750771848 no 2678 0.214611066516887 3773 2828568
SGTC_2892 9047358 58.44 µM -0.790861252179022 0.210787051980492 no 2679 0.214512480839075 3810 6466771
SGTC_2746 daunorubicin 9.88 µM -0.799416823214692 0.208296340141899 no 2680 0.212024379377495 3716 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3073 9114972 49.47 µM -0.800331094173495 0.208031206818945 no 2681 0.211759496101581 3771 41905075
SGTC_2900 5328528 85.29 µM -0.80096982498344 0.207846096817116 no 2682 0.211574557482845 3855 795359
SGTC_228 caffeine 993.056 µM -0.802682140447231 0.207350332384906 no 2683 0.211079239088914 3821 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2897 9048598 12.99 µM -0.804682159209517 0.206772155724616 no 2684 0.210501558703428 3826 6467404
SGTC_2161 5662504 8.5105 µM -0.805371366489754 0.206573137149705 no 2685 0.210302704982584 3812 2859334
SGTC_260 nsc-65238 3.989 µM -0.805435160454335 0.206554721458089 no 2686 0.210284304390452 3781 3246252
SGTC_992 3909-8734 162 µM -0.805617898877771 0.206501974915529 no 2687 0.210231600950825 3866 4288319
SGTC_3048 9093155 49.47 µM -0.807658231988116 0.20591358495817 no 2688 0.20964367718779 3765 25236002
SGTC_2851 9015922 71.43 µM -0.807956461727957 0.205827665039935 no 2689 0.209557823096777 3838 2996893
SGTC_1251 0490-5699 265 µM -0.808542079701605 0.205659010546126 no 2690 0.209389296147239 3855 3883818
SGTC_2861 9024595 19.48 µM -0.808860279787455 0.205567405217085 no 2691 0.209297759166476 3739 16482810
SGTC_1301 naphtanilide LB 4.81 µM -0.809035000696746 0.205517115828823 no 2692 0.209247507022066 3891 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1861 st057647 17.4 µM -0.81210843643766 0.204633693107948 no 2693 0.208364706359419 3917 688668
SGTC_2490 carminic acid 95.39 µM -0.812990799446708 0.20438048633379 no 2694 0.208111666616967 3752 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.813343981800067 0.204279187861407 no 2695 0.208010433558546 3876 5282362
SGTC_2534 helenine 20.12 µM -0.81385752383855 0.204131948958557 no 2696 0.207863288298392 3848 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1175 0741-0056 27.6 µM -0.813864308546319 0.204130004121457 no 2697 0.207861344686789 3928 765927
SGTC_608 k048-0125 159 µM -0.814756857941137 0.203874250994365 no 2698 0.207605750124219 3881 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1121 fusaric acid 630.51 nM -0.815130071560043 0.203767366164643 no 2699 0.20749893003608 3864 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_114 0364-0001 490.298 µM -0.815199298961918 0.203747543768811 no 2700 0.207479119547974 3921 4003655
SGTC_2471 5466956 24.79 µM -0.817351110277602 0.203131973043607 no 2701 0.206863903172216 3817 724419
SGTC_2199 6590217 200 µM -0.81919548303833 0.202605236269653 no 2702 0.20633744580332 3777 703109
SGTC_2791 5663188 71.43 µM -0.819648109827502 0.202476094874144 no 2703 0.206208369549487 3869 54690634
SGTC_2407 paclitaxel 400 µM -0.820419758910498 0.202256045008501 no 2704 0.205988427626981 4038 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1762 st045503 25.4615 µM -0.821319340841636 0.20199969342696 no 2705 0.205732196934478 3934 4645554
SGTC_453 enantio-paf c16 10 µM -0.8214786911778 0.201954304049516 no 2706 0.205686828415717 3778 13871343 A lipid and platelet activating factor
SGTC_501 nsc-95397 161 µM -0.823628166633954 0.20134264387616 no 2707 0.205075433281922 3885 262093
SGTC_1347 1493-0251 600 nM -0.826024118206341 0.200662156216546 no 2708 0.204395205269128 3912 3986378
SGTC_1778 st046819 58.9 µM -0.826393026138272 0.200557503401609 no 2709 0.204290589084484 3917 671715
SGTC_959 1222-0044 107 µM -0.82643471573327 0.200545678844378 no 2710 0.204278768610622 3828 6083612
SGTC_2177 5811945 192 µM -0.826602532818922 0.200498084565855 no 2711 0.204231190653959 3892 5343475
SGTC_955 1216-0110 33 µM -0.828127094795729 0.200066017316533 no 2712 0.203799263223908 3828 3619719
SGTC_1881 5652484 16 µM -0.828762353671511 0.199886147620832 no 2713 0.203619447292357 3823 2255129
SGTC_1193 1488-0126 41.5 µM -0.83023014255747 0.199470924222756 no 2714 0.203204338010993 3872 1384710
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.832037288857378 0.198960413640411 no 2715 0.202693948567905 3847 2346 DNA damaging agent; causes G2/M arrest.
SGTC_634 1611-4317 11.2 µM -0.833036524259726 0.198678472569378 no 2716 0.202412065313848 3871 2843522
SGTC_235 0330-0087 5 mM -0.833896974350031 0.198435883881597 no 2717 0.202169521187187 3895 46494818 YHR062C RPP1
SGTC_3216 9129716 49.47 µM -0.837611336243318 0.197390737743827 no 2718 0.201124511988543 3864 8056934
SGTC_2601 securinine 100 µM -0.838187671078543 0.197228867673358 no 2719 0.200962655110397 3843 442872 A GABA receptor antagonist.
SGTC_421 streptovitacin 30 mM -0.838966954237633 0.197010125048409 no 2720 0.20074392688594 3977 91467 include heat shock
SGTC_1659 st012954 42.1 µM -0.838987024471047 0.197004493329791 no 2721 0.200738295486018 3892 24207262
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.843197434744116 0.19582520529282 no 2722 0.199559016437031 3890 6857784
SGTC_1008 4106-0037 6 µM -0.843544342906664 0.195728231666381 no 2723 0.199462038420321 3841 2905394
SGTC_1880 MG-132 525 µM -0.846073851985799 0.195022022119356 no 2724 0.198755773288421 3830 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2301 7769476 200 µM -0.84616161439792 0.194997547711818 no 2725 0.198731296208689 3939 977820
SGTC_2008 4012253 172 µM -0.847736965314702 0.194558545407231 no 2726 0.198292237464169 3912 603940
SGTC_1396 3511-0007 98.6 µM -0.848640063348862 0.194307150956176 no 2727 0.198040803423394 3905 X1396
SGTC_1051 3253-3903 78 µM -0.848959273705878 0.194218340037635 no 2728 0.197951977251172 3894 5509239
SGTC_2135 5326629 150.42 µM -0.849582898656385 0.194044906030188 no 2729 0.197778511545124 3868 5020077
SGTC_98 0074-0023 107.663 µM -0.850800078241243 0.193706672680767 no 2730 0.19744020909716 3883 3563821
SGTC_2763 lisinopril 49.32 µM -0.851255020700365 0.193580344310447 no 2731 0.197313852446794 3813 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1054 3429-0080 167 µM -0.851775095433547 0.193435991585376 no 2732 0.197169465758548 3930 1162877
SGTC_2568 diosmetin 100 µM -0.851932488983931 0.193392318142724 no 2733 0.197125781693821 3944 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1186 1319-0216 26 µM -0.852119234633889 0.193340507906297 no 2734 0.197073958647388 3967 4565136
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.853149736100548 0.193054760560984 no 2735 0.196788136574208 3908 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2165 5727197 32.143 µM -0.853580901928187 0.192935279314906 no 2736 0.196668622032984 4074 1361712
SGTC_1221 2958-7315 257 µM -0.854295349712881 0.192737396671286 no 2737 0.19647068158556 3926 4562705
SGTC_2800 7887935 81.82 µM -0.855086824287911 0.192518324541197 no 2738 0.19625154158688 3944 2961002
SGTC_2467 5474540 200 µM -0.857335779584183 0.191896667787706 no 2739 0.195629670019336 3874 5413519
SGTC_2837 9008476 45.46 µM -0.858231903351907 0.191649303793442 no 2740 0.195382211384598 3906 2992805
SGTC_3015 9080845 49.47 µM -0.858548459970908 0.191561968914365 no 2741 0.195294841842767 3989 5296973
SGTC_533 1222-0222 6.71 µM -0.859074620087898 0.191416860427003 no 2742 0.195149674320073 3993 3982874
SGTC_455 paf C-16 10 µM -0.86224220582686 0.190544703354668 no 2743 0.194277124383202 3892 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1755 st041960 45.185 µM -0.862696830550656 0.19041972835288 no 2744 0.194152087729311 3987 2257073
SGTC_1711 st032263 62.8 µM -0.86407987815055 0.190039842235562 no 2745 0.19377200593786 3920 3958979
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.866489323245806 0.189379145780655 no 2746 0.193110939441154 3954 6708760
SGTC_1703 st026983 48.3 µM -0.868930353558411 0.18871123196036 no 2747 0.192442613017701 3922 1104023
SGTC_1329 1447-1697 50.6 µM -0.869258875506302 0.188621452892051 no 2748 0.192352775526097 3940 2840515
SGTC_1082 camptothecin 424.86 nM -0.870525338492535 0.188275598098454 no 2749 0.192006689091304 3851 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1678 st019265 80.2 µM -0.870635943884108 0.188245411773293 no 2750 0.191976482052308 3936 5367020
SGTC_3200 9114385 49.47 µM -0.871962342810365 0.187883644825512 no 2751 0.191614460652559 3984 17018030 YLR208W SEC13
SGTC_994 3910-0338 138 µM -0.872185693480948 0.187822769596147 no 2752 0.191553541478514 4023 3479481
SGTC_1383 3049-0032 20.7 µM -0.87293940703188 0.187617431503504 no 2753 0.191348052757061 4007 712864
SGTC_3042 9091578 49.47 µM -0.873185619051037 0.18755038475126 no 2754 0.191280956019544 3877 25236497
SGTC_2152 5568786 200 µM -0.876014216981681 0.18678118301101 no 2755 0.190511152496712 3892 5399883
SGTC_331 k048-0133 24.5 µM -0.878281687409249 0.186165985025195 no 2756 0.189895435589055 3915 6813582
SGTC_1216 1165-0504 9.65 µM -0.87911150742174 0.185941156934987 no 2757 0.189670409481296 3964 6304004
SGTC_3135 9127742 49.47 µM -0.881456032305405 0.185306851145532 no 2758 0.189035520780239 4020 3643468
SGTC_845 0330-0138 4.51 µM -0.883367330684534 0.184790749124091 no 2759 0.188518917972838 3891 9039800
SGTC_1109 tnp00067 928.257 nM -0.883653718748702 0.184713493677887 no 2760 0.188441585511956 3943 676295
SGTC_1654 st012436 41.8 µM -0.885883475194689 0.184112686206543 no 2761 0.187840160819409 3891 4323132
SGTC_63 0099-0242 26.702 µM -0.885997593198177 0.184081969889091 no 2762 0.187809412074331 3994 3898502 YLR359W ADE13
SGTC_548 1436-0017 110 µM -0.887582702341405 0.18365564748754 no 2763 0.187382630816442 4029 9677137
SGTC_2132 5317594 122.667 µM -0.888143375816972 0.183504999181073 no 2764 0.187231816442036 3927 794577
SGTC_1009 4106-0057 9.87 µM -0.888201222139729 0.183489460739022 no 2765 0.187216260754388 3899 2928005
SGTC_2647 atorvastatin 60.16 µM -0.890786708229506 0.182795795743392 no 2766 0.186521803602935 3939 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_85 0868-0259 160.055 µM -0.891715662842373 0.182546964995712 no 2767 0.186272678048699 3901 83173
SGTC_3260 9137109 49.47 µM -0.892179470411408 0.182422808235834 no 2768 0.18614837208465 3881 17478346
SGTC_1386 3228-0095 33.8 µM -0.892289947497876 0.182393242379187 no 2769 0.18611877049051 3986 870181
SGTC_762 1165-0429 115 µM -0.892980303848079 0.182208557156644 no 2770 0.185933860227458 3947 5967793
SGTC_2796 7949634 45.45 µM -0.893827279595324 0.181982132589969 no 2771 0.1857071555129 3906 2971588
SGTC_1112 tnp00069 1.16933 µM -0.89407468797283 0.181916025384017 no 2772 0.18564096563118 3972 145826
SGTC_793 0488-0545 106 µM -0.895114771902621 0.181638280579363 no 2773 0.185362869101362 3983 292548
SGTC_394 menadione 8.33 µM -0.895544310870644 0.18152365363049 no 2774 0.185248094933775 3957 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2102 5377816 72.7585 µM -0.89613454862091 0.181366216409725 no 2775 0.185090453547808 4017 1379702
SGTC_2896 9052656 71.43 µM -0.904450309140523 0.179157204533385 no 2776 0.182878335909452 3859 6469436
SGTC_1263 0774-1208 64.8 µM -0.906945672669315 0.178497647353806 no 2777 0.182217763533619 4002 906585
SGTC_40 0327-0103 19.753 µM -0.909750410287725 0.177758146730108 no 2778 0.181477076188277 3865 409036
SGTC_2284 7945075 39.21 µM -0.910674201697007 0.177515002473226 no 2779 0.181233530504413 4001 1245402
SGTC_529 4076-0302 30.3 µM -0.911070647226686 0.177410721402838 no 2780 0.181129075559149 3932 5816522
SGTC_1060 3448-7350 82 µM -0.911226839196995 0.177369647274147 no 2781 0.18108793266296 3949 570178
SGTC_2213 7173844 200 µM -0.911884143986586 0.177196860266964 no 2782 0.180914854625109 3939 892728
SGTC_1476 4112-3294 3.34 µM -0.912081697844998 0.177144949679236 no 2783 0.18086285605135 4019 704369
SGTC_910 3454-3003 490 µM -0.913280524426945 0.176830143950615 no 2784 0.180547511277487 3926 820824
SGTC_735 3076-0345 636 µM -0.913893716136438 0.176669259722468 no 2785 0.180386347938613 4062 2888990
SGTC_1512 0259-0544 12.2 µM -0.915754117675227 0.17618170937147 no 2786 0.179897936741405 3957 18476
SGTC_2899 9053889 58.44 µM -0.916188887205877 0.176067893386344 no 2787 0.179783916539205 3947 6470052
SGTC_891 0929-0073 133 µM -0.917888547854106 0.17562339515327 no 2788 0.1793386089147 4053 5603632
SGTC_3170 9103054 49.47 µM -0.918572025819448 0.175444851438031 no 2789 0.179159734770847 4014 16432970
SGTC_1871 st057448 67.3 µM -0.920078389374042 0.175051753218471 no 2790 0.17876589828334 4025 691747
SGTC_2437 5741531 144.16 µM -0.920866465334799 0.174846320985878 no 2791 0.178560074331601 4031 2262990
SGTC_1405 3909-7894 12 µM -0.922396900767283 0.174447811002595 no 2792 0.178160792887153 3998 7104060
SGTC_184 1494-0393 24.714 µM -0.922529443767521 0.174413325306953 no 2793 0.178126239712302 3982 3090647
SGTC_1715 st032160 10.2275 µM -0.922556834162302 0.174406199278075 no 2794 0.178119099725402 3959 5289825
SGTC_3056 9094900 49.47 µM -0.922679969920583 0.174374165917632 no 2795 0.178087003559478 3986 25236784
SGTC_1619 st003326 88.7 µM -0.923254374339001 0.174224785897995 no 2796 0.177937329353132 3984 2849032
SGTC_53 0973-0023 39.979 µM -0.92480320294681 0.173822401852179 no 2797 0.177534142125657 3885 674768
SGTC_2786 7743617 45.45 µM -0.925050127312183 0.173758305832364 no 2798 0.177469916718972 3950 583674
SGTC_3345 9148410 3.559 µM -0.925264519578064 0.173702666610252 no 2799 0.177414164858293 3982 4903596
SGTC_3178 9107506 49.47 µM -0.927194664680178 0.173202264528415 no 2800 0.176912736231617 4043 8897194
SGTC_1937 st074714 47.2 µM -0.930254355021327 0.172410903983086 no 2801 0.176119702466495 3957 17250970
SGTC_1602 st001878 87.6 µM -0.932461187010836 0.171841561300558 no 2802 0.175549118083905 4017 595405 YLR310C CDC25
SGTC_1622 st003707 19.4 µM -0.932628002135626 0.171798573371398 no 2803 0.175506035108442 4034 10140899
SGTC_1173 0443-0020 122 µM -0.932827531469103 0.171747164076406 no 2804 0.175454511908858 4005 5331295
SGTC_2322 7413319 38.22 µM -0.93345853700247 0.171584648404325 no 2805 0.175291634449469 4067 1840400
SGTC_1352 1496-0991 99 µM -0.935263664111679 0.171120280153701 no 2806 0.17482621808829 3996 3000039
SGTC_775 4577-0580 57.3 µM -0.93618020474127 0.170884808373524 no 2807 0.174590206692595 4091 2006902
SGTC_3343 9148379 18.9835 µM -0.936992567658769 0.170676274670475 no 2808 0.174381190522665 4060 1955036
SGTC_1144 3486-0183 12.5 µM -0.937418894449268 0.170566901712509 no 2809 0.174271562794059 4000 6744069
SGTC_1154 4088-0362 150 µM -0.939002872027874 0.170160929854359 no 2810 0.173864634885495 4009 6618304
SGTC_1192 1488-0095 21.4 µM -0.940261883371635 0.169838688552422 no 2811 0.173541623038488 4065 915875
SGTC_641 4092-0595 30 µM -0.942291261904255 0.169320097657057 no 2812 0.173021770320025 4047 786260
SGTC_2180 6301957 200 µM -0.94233175247233 0.16930976098026 no 2813 0.173011408218787 4029 845462
SGTC_603 3794-0023 45.9 µM -0.944064731188521 0.168867735397859 no 2814 0.172568285389137 4046 3802260
SGTC_783 0848-0141 92.7 µM -0.944332081918996 0.168799609137379 no 2815 0.172499988272833 3966 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3213 9129884 49.47 µM -0.944569971322993 0.168739005056814 no 2816 0.172439231809293 4031 17190742
SGTC_990 3985-0011 41.3 µM -0.946132462726731 0.168341296441814 no 2817 0.172040514018975 4018 5399565 YGL099W LSG1
SGTC_2245 6637752 200 µM -0.946305925357688 0.1682971813561 no 2818 0.171996286009906 4098 681890
SGTC_488 nitrendipine 139 µM -0.94881948056733 0.16765876767988 no 2819 0.171356216134943 4073 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2730 imipramine 71.33 µM -0.949167114984439 0.167570595530202 no 2820 0.171267812001344 4008 3696 A tricyclic antidepressant.
SGTC_2267 7931562 200 µM -0.949780948635406 0.167414978968648 no 2821 0.171111784082001 3952 934880
SGTC_2383 9036125 200 µM -0.953237372954544 0.166540459747771 no 2822 0.170234907304389 3949 79580
SGTC_1853 st056710 91.2 µM -0.953962980475719 0.166357247000864 no 2823 0.170051190754428 4108 269167
SGTC_284 0988-0104 32.6 µM -0.956838707653074 0.165632418975486 no 2824 0.16932433583076 4021 4666532
SGTC_733 4069-0007 56.1 µM -0.958859143902664 0.165124390673213 no 2825 0.168814854656432 4037 5717425 YNL287W SEC21
SGTC_1091 telmisartan 47.6 µM -0.963437458964386 0.163976933642507 no 2826 0.167664017762501 4098 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1850 st056238 17 µM -0.966781280807734 0.163142153044498 no 2827 0.166826692095516 4060 5393177
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.967470145222938 0.162970522673822 no 2828 0.166654529412743 4168 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_669 0108-0021 26.2 µM -0.970130382861572 0.162308827619183 no 2829 0.165990753103866 3969 17201
SGTC_887 0885-0007 9.62 µM -0.972845852844241 0.161635200647938 no 2830 0.165314959850329 4138 5719458
SGTC_1931 st074438 57.1 µM -0.973218808069696 0.161542824137723 no 2831 0.165222282521114 4020 2787313
SGTC_162 k030-0015 37.8 µM -0.975242239771495 0.161042244584263 no 2832 0.164720057076124 4147 1809920 YMR134W ERG29
SGTC_1443 4112-3303 14 µM -0.975863055593608 0.160888863260033 no 2833 0.164566166094989 4096 704433
SGTC_2440 5628896 157.78 µM -0.979954189781991 0.159880476495526 no 2834 0.163554365978057 4055 5522048
SGTC_969 1313-0238 134 µM -0.982172866122727 0.159335347612667 no 2835 0.163007346347039 4089 5212874
SGTC_2747 doxorubicin 7.63 µM -0.983477038044178 0.159015481147768 no 2836 0.162686355503936 4019 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_550 4123-0385 25.7 µM -0.985808176689911 0.158444785550249 no 2837 0.162113626281334 4098 5731123
SGTC_1673 st016611 27.3 µM -0.986374577959493 0.158306325662038 no 2838 0.161974667667294 4101 5226799
SGTC_763 3453-1109 128 µM -0.986721547021766 0.158221546400777 no 2839 0.161889582004624 4101 1560353
SGTC_469 w7 172 µM -0.987180190336533 0.158109526113214 no 2840 0.161777155662119 4131 45115570 A P450 inhibitor.
SGTC_2690 usnic acid 100 µM -0.987308955995524 0.158078085400912 no 2841 0.161745600736478 4113 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_916 4466-0038 42 nM -0.989542543908977 0.15753336328047 no 2842 0.161198882680954 4151 5722064 YGL116W CDC20
SGTC_866 0495-0101 262 µM -0.991067161906929 0.157162252221751 no 2843 0.160826393207366 4042 635694
SGTC_715 0868-0130 184 µM -0.991750556989838 0.156996092079087 no 2844 0.160659610994327 4133 2876258
SGTC_745 0469-0705 296 µM -0.991901017486647 0.156959524759948 no 2845 0.160622906366691 4159 3486736
SGTC_1647 st011722 22.4 µM -0.993571720061154 0.156553860429497 no 2846 0.160215708903063 4059 2854783
SGTC_3011 9081274 71.4286 µM -0.99426765625473 0.156385083566658 no 2847 0.160046288829445 4079 6625322
SGTC_1556 plumbagin 1.48 µM -0.994687458201074 0.156283332120431 no 2848 0.159944148085525 4003 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2253 7938677 135.83 µM -0.995208427188605 0.156157120497623 no 2849 0.159817451989078 4158 2301972
SGTC_3190 9110366 49.47 µM -0.995404015332794 0.156109754029043 no 2850 0.159769903245143 4077 17123768
SGTC_2259 7964009 200 µM -0.99747442931543 0.15560893307525 no 2851 0.15926713980502 4135 313134
SGTC_2479 5617353 43.85 µM -0.997724717149921 0.15554846180153 no 2852 0.159206432101215 4142 2731746
SGTC_2372 9071633 200 µM -0.998012722658368 0.155478896861529 no 2853 0.159136594673328 4110 21321366
SGTC_1726 st035556 14.5795 µM -1.00158713616284 0.154617240303258 no 2854 0.158271518206368 4187 5919439
SGTC_522 1273-0010 11.6 µM -1.00279221078469 0.154327454851805 no 2855 0.157980563918896 4193 5705015
SGTC_2359 9039622 200 µM -1.00330221739457 0.15420492129954 no 2856 0.157857533295364 4041 6463596
SGTC_948 3448-0295 75.3 µM -1.00339260506475 0.154183211585049 no 2857 0.15783573533685 4069 678569
SGTC_1753 st043925 64 µM -1.0038439426399 0.154074837560638 no 2858 0.157726920008482 4136 670181
SGTC_2608 thymoquinone 42.66 µM -1.00445166567726 0.153928992289524 no 2859 0.157580478760824 4083 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2054 5233173 129 µM -1.00932234561537 0.152763396410614 no 2860 0.156410033426031 4135 6889
SGTC_2121 5257820 149.641 µM -1.01074748160167 0.152423458924762 no 2861 0.156068652573964 4140 791256
SGTC_2940 9060638 45.86 µM -1.01137132771648 0.152274811102029 no 2862 0.155919369454388 4089 4027022
SGTC_1222 0366-0074 1.18 µM -1.01287349655096 0.151917274667398 no 2863 0.155560294622202 4115 286520
SGTC_2085 5307070 144.047 µM -1.01339310619971 0.151793730489069 no 2864 0.155436215458593 4037 2840351
SGTC_2778 tioconazole 65.09 nM -1.01461907511847 0.151502504547817 no 2865 0.155143721486846 3996 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3298 9116858 71.43 µM -1.01483725852867 0.151450714572647 no 2866 0.155091704991792 4171 2506942
SGTC_2300 7976697 71.57 µM -1.01510505778758 0.151387163427136 no 2867 0.155027875463649 3995 2236109
SGTC_1742 st038235 28.8875 µM -1.01563665712324 0.151261062725741 no 2868 0.15490122100818 4159 564103 YBR002C RER2
SGTC_3232 9132874 49.47 µM -1.01722867754841 0.15088383752765 no 2869 0.154522328334193 4065 3784940
SGTC_171 k064-0041 9.68 µM -1.01771825460282 0.150767959490788 no 2870 0.154405934774558 4132 53325
SGTC_2244 6635614 200 µM -1.01781630517392 0.150744759015873 no 2871 0.154382630897921 4030 836499
SGTC_1490 4089-0339 670 nM -1.01789472860142 0.150726204376445 no 2872 0.154363993517892 4054 742542
SGTC_290 2043-6722 48.1 µM -1.01877976856299 0.150516913218797 no 2873 0.154153766309536 4129 773758 YLR208W SEC13
SGTC_1874 staurosporine 7.6 µM -1.01993650352178 0.150243664554122 no 2874 0.153879287904157 4154 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1782 st039423 80.636 µM -1.02009455355305 0.150206355017285 no 2875 0.153841809785353 4141 2068169
SGTC_521 r062-0005 13.8 µM -1.02072030185655 0.15005870052435 no 2876 0.153693486533319 4023 2832033
SGTC_1756 st041558 35.5 µM -1.02138113250434 0.149902872931168 no 2877 0.153536950412861 4205 3955792
SGTC_2200 6600604 21.907 µM -1.02420588314519 0.149237997718781 no 2878 0.152869020282193 4094 2904777
SGTC_1456 k015-0012 13 µM -1.02482925055309 0.149091538354742 no 2879 0.152721881030328 4118 2989616
SGTC_2517 totarol 10 µM -1.02715225667288 0.148546596811384 no 2880 0.152174387670973 4129 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1434 4073-0095 163 µM -1.0273605173657 0.148497807185888 no 2881 0.152125367873313 4055 24133745
SGTC_778 3456-2434 196 µM -1.02889545110432 0.148138545916791 no 2882 0.151764403094314 4083 5539063
SGTC_2381 9035592 200 µM -1.02926438278955 0.148052281814357 no 2883 0.151677727684351 4114 4749657
SGTC_3052 9092717 49.47 µM -1.02973780227229 0.147941635494187 no 2884 0.151566552513994 4134 25237534
SGTC_3021 9087658 49.47 µM -1.02996534127281 0.147888475395679 no 2885 0.151513137813855 4113 25237042
SGTC_822 1487-0950 154 µM -1.0311882959377 0.14760297472534 no 2886 0.151226264057012 4145 1958375
SGTC_1461 k072-0203 53.8 µM -1.0352665840727 0.146653561897256 no 2887 0.150272215425265 4033 5418714
SGTC_341 1486-1430 230 µM -1.03726498373002 0.146189839939894 no 2888 0.149806190062334 4089 2054753 YPL210C SRP72
SGTC_2891 9063876 19.48 µM -1.03797671616483 0.146024922899571 no 2889 0.149640447624969 4123 6472478
SGTC_68 0986-0284 82.829 µM -1.0407808925969 0.145376377929037 no 2890 0.148988624977819 4192 423278 YIL048W NEO1
SGTC_2421 5690543 90.72 µM -1.04215847321177 0.14505848432319 no 2891 0.148669106218984 4149 3397993
SGTC_3013 9080133 71.4286 µM -1.04323979267358 0.144809284616279 no 2892 0.148418623976821 4225 17050193
SGTC_561 1550-0330 72.9 µM -1.04780342106564 0.143760732957039 no 2893 0.147364592999937 4080 6812934
SGTC_3255 9139072 49.47 µM -1.04794088206985 0.143729229223097 no 2894 0.147332922561164 4161 17646060
SGTC_1530 rhein 70.4 µM -1.04962841831704 0.143342854137407 no 2895 0.146944493032579 4206 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_693 4161-2696 114 µM -1.05007377674062 0.143241002803811 no 2896 0.146842097077735 4165 805759
SGTC_2254 7938975 95.19 µM -1.05563211182633 0.141973950057753 no 2897 0.145568162041701 4243 2969277
SGTC_3083 9117465 49.47 µM -1.05671783882766 0.14172734123358 no 2898 0.145320190553625 4142 16420915
SGTC_2211 7117706 200 µM -1.05736460196765 0.141580575339475 no 2899 0.145172610091078 4074 822771
SGTC_1976 st070609 63.5 µM -1.05811253528698 0.141410979965404 no 2900 0.145002070093603 4052 682556
SGTC_259 usnic acid 108.925 µM -1.06321767986254 0.140257056041925 no 2901 0.143841623252335 4241 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1644 st010134 20.9 µM -1.06673309218885 0.139466190057724 no 2902 0.143046189670765 4142 3818134
SGTC_286 k060-0067 22.9 µM -1.06809172298187 0.139161351718602 no 2903 0.142739569560547 4159 5985051
SGTC_1219 1469-0211 33.1 µM -1.06812377230705 0.139154166235093 no 2904 0.142732341935369 4192 6822282
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.06830965773693 0.13911249555737 no 2905 0.1426904267363 4172 66535 A nucleotide analog.
SGTC_3222 9128301 49.47 µM -1.06909451913726 0.138936643695281 no 2906 0.142513540545554 4174 4911358
SGTC_1691 st019933 84.6 µM -1.06999263698572 0.138735601960114 no 2907 0.142311311481985 4154 6176082
SGTC_335 4077-0256 27.6 µM -1.07111636973554 0.138484336002682 no 2908 0.142058554308998 4125 3121989
SGTC_2389 9091542 195.52 µM -1.07276691372196 0.138115837931537 no 2909 0.141687854630313 4155 3626624 YOL127W RPL25
SGTC_2107 5363541 170.161 µM -1.07386209241879 0.137871699262594 no 2910 0.141442247731494 4139 244052
SGTC_2880 9042983 58.44 µM -1.07449448054132 0.137730860636009 no 2911 0.141300558620625 4159 6464714
SGTC_2478 5763493 32.33 µM -1.07659821198638 0.137263047080719 no 2912 0.140829901687068 4097 1365576 YLR208W SEC13
SGTC_1404 3909-7820 48.3 µM -1.07675855747255 0.137227435101325 no 2913 0.140794072097698 4144 23741373
SGTC_2076 5212012 200 µM -1.07941394755699 0.136638602985727 no 2914 0.140201618011781 4121 604802
SGTC_3280 9140961 49.47 µM -1.07955243168509 0.136607941635606 no 2915 0.140170766825306 4206 4901226
SGTC_594 1487-1584 10.8 µM -1.08033871197968 0.136433942900043 no 2916 0.139995688475 4129 5013332
SGTC_349 k015-0014 24 µM -1.08052820278579 0.136392032492175 no 2917 0.139953517434309 4166 2196908
SGTC_1859 st055998 20 µM -1.0806110088253 0.136373720728594 no 2918 0.139935091721397 4127 676301
SGTC_444 curcumin 90.4 µM -1.08062733330709 0.136370110924073 no 2919 0.139931459448837 4113 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1185 1319-0113 81.3 µM -1.08261455097871 0.135931169172499 no 2920 0.139489772951695 4237 4672763
SGTC_484 loperamide 105 µM -1.08551928404659 0.135291306333158 no 2921 0.138845863723927 4184 3955 An opioid-receptor agonist.
SGTC_524 r073-0010 27.8 µM -1.08658471862584 0.135057127760749 no 2922 0.138610190771052 4116 2772106
SGTC_706 4262-0057 46.9 µM -1.08839927774371 0.134658934581573 no 2923 0.138209439935796 4183 883298
SGTC_2458 5808907 16.39 µM -1.08913099177448 0.134498592889433 no 2924 0.138048062413208 4325 2731747
SGTC_2299 7976368 114.88 µM -1.08938135603516 0.134443760267376 no 2925 0.137992874781703 4214 2979718
SGTC_3149 9097855 49.47 µM -1.0926658777002 0.13372583393492 no 2926 0.137270263382012 4197 25236625 YMR079W SEC14
SGTC_809 3998-0021 90 µM -1.09282929662541 0.133690183004038 no 2927 0.137234378007423 4142 715485
SGTC_1938 st074717 56.4 µM -1.09525681522453 0.133161373018665 no 2928 0.13670207053769 4079 17250979
SGTC_2012 4023501 200 µM -1.09815364730446 0.13253221402049 no 2929 0.13606870141259 4214 3477460
SGTC_1508 1080-0625 72.9 µM -1.09942385197637 0.132256986954717 no 2930 0.135791615822483 4088 767111
SGTC_2095 5432005 200 µM -1.10051319328988 0.132021263282762 no 2931 0.135554292226246 4195 783734
SGTC_3350 9150499 3.57 µM -1.10052479979483 0.132018753300348 no 2932 0.135551765167314 4180 4910996 YPR165W RHO1
SGTC_2134 5324836 1.464 µM -1.10296477627013 0.131491823008045 no 2933 0.135021230975604 4146 699272
SGTC_597 k018-0003 82.8 µM -1.10301929481548 0.131480065945641 no 2934 0.135009393070536 4264 6786234
SGTC_592 k241-0073 46.5 µM -1.10506340282661 0.131039772496629 no 2935 0.134566058533395 4232 4230158
SGTC_554 4483-2211 187 µM -1.11167610607677 0.129622402868994 no 2936 0.133138718406977 4262 747107
SGTC_2431 5490079 200 µM -1.11445049324162 0.129030913396293 no 2937 0.132542985901984 4267 5722345
SGTC_2685 mycophenolic acid 18.85 µM -1.11561356831722 0.128783507549312 no 2938 0.132293790840433 4187 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1464 k208-0027 110 µM -1.11709196553597 0.128469502607589 no 2939 0.1319775027241 4219 X1464
SGTC_1177 0983-0204 23.6 µM -1.12203682511797 0.127423099810507 no 2940 0.130923391388476 4241 766818
SGTC_1359 1582-0056 520 nM -1.12417149960346 0.126973209018883 no 2941 0.130470138834288 4268 3661189
SGTC_2576 guaiol 23.12 µM -1.12505843762225 0.126786608944103 no 2942 0.130282135976413 4128 227829
SGTC_193 1273-0060 1.558 µM -1.12611645912346 0.126564264997957 no 2943 0.130058114065871 4049 2847393 YHR072W ERG7
SGTC_1920 st075728 45.7 µM -1.12642937045397 0.12649855853878 no 2944 0.129991910389885 4203 3400306
SGTC_2546 rhodinyl acetate 100 µM -1.12871458126173 0.126019420662119 no 2945 0.129509128102256 4175 6708682
SGTC_2596 sinensetin 100 µM -1.12966874158183 0.125819737760241 no 2946 0.129307916665193 4235 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2516 gossypol 71.55 µM -1.12986263938221 0.12577918658967 no 2947 0.129267054383578 4244 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2273 7815444 169.05 µM -1.13058361498169 0.125628484015846 no 2948 0.129115193538549 4185 2824616
SGTC_2351 9026858 72.31 µM -1.13082681677243 0.125577676970715 no 2949 0.129063995263646 4129 1409300
SGTC_1617 st002906 78 µM -1.13092044347296 0.125558121332355 no 2950 0.129044288941839 4209 5150859
SGTC_1842 st055362 61.2 µM -1.13239675299146 0.125250048163571 no 2951 0.128733834680246 4182 676032
SGTC_2910 7948405 25.97 µM -1.13322862246225 0.125076688057518 no 2952 0.128559128651677 4137 2971328
SGTC_3207 9114163 49.47 µM -1.13408721900871 0.12489793390036 no 2953 0.128378982140928 4256 849233
SGTC_1603 st002045 67.8 µM -1.13426530770115 0.124860879366051 no 2954 0.128341638401915 4227 5887985
SGTC_2799 7812892 81.82 µM -1.13727380647672 0.124236068124411 no 2955 0.127711920578055 4257 20205235
SGTC_2725 haloperidol 53.21 µM -1.13888464638912 0.123902426031825 no 2956 0.127375635131519 4164 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1971 st069429 63.5 µM -1.14122885951349 0.123418006656653 no 2957 0.126887348835802 4219 1246522 YGL099W LSG1
SGTC_2514 salinomycin 42.74 µM -1.14235106256521 0.12318657946216 no 2958 0.126654062089465 4291 23682228 A polyether potassium ionophore.
SGTC_1661 st013063 9.66 µM -1.14240631829974 0.123175192166791 no 2959 0.126642583092003 4287 721395
SGTC_1977 st070720 65.3 µM -1.14792869409207 0.122040840868623 no 2960 0.12549900077505 4272 682188
SGTC_1139 k015-0024 46.9 µM -1.14996523913252 0.121624371482759 no 2961 0.125079094303578 4269 2766652
SGTC_1689 st020265 53.493 µM -1.15146032147645 0.121319266603139 no 2962 0.124771454967686 4251 5758320 YPR016C TIF6
SGTC_966 1300-0360 30.2 µM -1.15218999614806 0.12117055581464 no 2963 0.124621503805556 4229 70588
SGTC_3267 9137951 49.47 µM -1.15228850032565 0.121150490072919 no 2964 0.124601270444415 4271 16643986
SGTC_1157 4092-0394 27.6 µM -1.15240678106442 0.121126398845618 no 2965 0.124576977890858 4314 3659885
SGTC_2040 5100729 123 µM -1.15352040319029 0.120899743327237 no 2966 0.124348423979237 4271 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1421 4029-0249 71.4 µM -1.15359995096604 0.120883564396757 no 2967 0.124332109243705 4325 2894095
SGTC_54 0159-0055 9 µM -1.15605496416132 0.120384997223283 no 2968 0.123829337771483 4256 3319099
SGTC_3284 9108171 64.8615 µM -1.1560710642487 0.120381732384697 no 2969 0.123826045277525 4228 8687505
SGTC_1626 st003712 1.76 µM -1.15805583079486 0.119979731315379 no 2970 0.123420626647016 4289 24207035
SGTC_523 1934-0222 13.7 µM -1.15996181169329 0.119594579287254 no 2971 0.123032177270147 4193 1361595
SGTC_255 tunicamycin 200.472 nM -1.16046128223796 0.119493792904355 no 2972 0.122930524308004 4169 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_846 0335-0850 148 µM -1.16267730038187 0.119047353228847 no 2973 0.122480227398308 4216 6819598
SGTC_3224 9130643 49.47 µM -1.16445175641823 0.11869072080994 no 2974 0.122120491731134 4334 17644395
SGTC_2866 9034245 58.44 µM -1.16636602380415 0.118306836022288 no 2975 0.121733244688191 4242 6462273
SGTC_2034 5197015 53.07 µM -1.16802191042186 0.117975475362583 no 2976 0.121398963508294 4269 780676
SGTC_1220 1838-0075 193 µM -1.16849204700574 0.117881515772168 no 2977 0.121304172690819 4163 5529645
SGTC_2240 6690706 185.951 µM -1.17132029339025 0.117317391193328 no 2978 0.120735028670947 4132 805876
SGTC_215 1287-0124 461.5 µM -1.17153634164735 0.117274376753618 no 2979 0.120691629466457 4267 5560863
SGTC_802 4112-3352 742 µM -1.172010463263 0.117180019984788 no 2980 0.120596427663635 4324 704594
SGTC_2279 7948423 32.93 µM -1.17432991091157 0.116719192904584 no 2981 0.120131453537639 4255 1247112
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.17777203211948 0.116037684117108 no 2982 0.119443750644941 4307 688788
SGTC_2740 felodipine 17.08 µM -1.17975238902213 0.115646873880163 no 2983 0.119049355340447 4303 3333 L-type calcium channel blocker
SGTC_311 1315-0136 58 µM -1.18034536540193 0.115530036049443 no 2984 0.118931441008219 4279 6759207
SGTC_1453 4237-0541 195 µM -1.1809063471428 0.115419579547816 no 2985 0.118819964807324 4265 739892
SGTC_2022 5136654 200 µM -1.18393096707642 0.114825329321868 no 2986 0.118220195316762 4295 1713771
SGTC_23 0213-0011 39.996 µM -1.18554346954415 0.114509410272406 no 2987 0.117901319113046 4273 627608
SGTC_917 harmaline 728.087 nM -1.1894360978523 0.113749323177796 no 2988 0.117134051538889 4215 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.19384103709271 0.112893545762921 no 2989 0.116270077851816 4269 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_579 4491-1009 110 µM -1.19814563168195 0.112061712745425 no 2990 0.11543016342694 4394 1271041
SGTC_2822 7994718 71.43 µM -1.1998338125918 0.111736682633512 no 2991 0.115101944716809 4265 1018011
SGTC_2041 5107442 45.335 µM -1.20190286843953 0.111339242061075 no 2992 0.114700581485908 4320 793005
SGTC_2541 muurolladie-3-one 83.07 µM -1.20264042017458 0.11119781224834 no 2993 0.114557749479612 4250 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2960 9079389 5.97 µM -1.20434470547058 0.110871497820243 no 2994 0.114228187160873 4287 16457355
SGTC_1146 3579-1023 7 µM -1.21057300584147 0.109684819491482 no 2995 0.113029547563482 4319 X1146
SGTC_3339 9145883 14.936 µM -1.21112329415617 0.109580413122028 no 2996 0.112924077495071 4206 2030670
SGTC_1426 4048-4480 71.7 µM -1.21340270011 0.109148700750635 no 2997 0.112487947251391 4295 14224343
SGTC_3003 9075612 71.4286 µM -1.21539227245139 0.108772882074713 no 2998 0.112108256955897 4314 6501993
SGTC_3201 9113999 49.47 µM -1.21556538892968 0.108740225434092 no 2999 0.112075262757947 4290 16649224
SGTC_1089 terbinafine 2.25 µM -1.21698953679232 0.108471842156706 no 3000 0.111804098434508 4313 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2739 tacrine 100.86 µM -1.21918669905727 0.108058718223915 no 3001 0.111386669563993 4358 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1424 4048-1941 275 µM -1.21932128714697 0.10803344901676 no 3002 0.111361136091351 4374 X1424
SGTC_108 0509-0257 621.132 µM -1.22220004022043 0.107493975273077 no 3003 0.110815994339571 4252 536624
SGTC_2123 5259487 200 µM -1.22259265077529 0.10742055139272 no 3004 0.110741795150346 4323 2173474
SGTC_3045 9092950 49.47 µM -1.22365217703571 0.107222585009672 no 3005 0.110541733727552 4288 44120432
SGTC_3007 9078383 71.4286 µM -1.22469584501262 0.107027838971765 no 3006 0.110344920110833 4292 6496995
SGTC_2408 sulbentine 18.36 µM -1.22508380922094 0.106955510831337 no 3007 0.110271822402653 4206 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2898 9056270 58.44 µM -1.22636296708372 0.106717287314768 no 3008 0.110031057774497 4301 19154699
SGTC_122 0236-0016 402.397 µM -1.22891101893109 0.106243893363648 no 3009 0.109552584825956 4301 6808838
SGTC_3197 9113331 49.47 µM -1.23044638829963 0.105959375619475 no 3010 0.109264995669355 4308 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_3091 9116372 49.47 µM -1.23173150519294 0.105721655540903 no 3011 0.10902469847535 4363 17169793
SGTC_2844 9010103 25.97 µM -1.23278261339102 0.105527509071184 no 3012 0.108828439895655 4319 2480525
SGTC_1241 0364-0022 50.8 µM -1.23383199288027 0.105333939239835 no 3013 0.108632757611544 4307 4563895
SGTC_1286 0929-0070 131 µM -1.23472566432927 0.105169294137834 no 3014 0.108466310506461 4390 1420408
SGTC_3049 9092223 49.47 µM -1.23566730829018 0.104996012427409 no 3015 0.108291127084829 4297 8623917
SGTC_911 3456-4043 236 µM -1.23582268800043 0.104967439265197 no 3016 0.10826223983019 4310 914281
SGTC_480 am 92016 50 µM -1.23765865624881 0.104630244615389 no 3017 0.107921327593673 4326 2129 K+ channel blocker.
SGTC_3155 9099265 49.47 µM -1.23810082866682 0.1045491524198 no 3018 0.107839338335996 4307 25236499
SGTC_568 1193-0097 7.48 µM -1.24424520014712 0.103427014640646 no 3019 0.10670466642096 4125 3646150
SGTC_2143 5623677 140.463 µM -1.2444257311004 0.103394177251964 no 3020 0.106671458835038 4249 5375313
SGTC_1090 efavirenz 20.7 µM -1.24504886250222 0.103280891908335 no 3021 0.106556894857694 4339 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2813 7971799 71.43 µM -1.24888413420905 0.102585623045803 no 3022 0.10585372769844 4332 2234054
SGTC_369 0957-0393 4.5 µM -1.24914988658326 0.102537573057712 no 3023 0.105805128614903 4338 6997992
SGTC_3118 9124250 49.47 µM -1.24941121449676 0.102490339002346 no 3024 0.105757354378169 4279 1504786
SGTC_2868 9035608 32.47 µM -1.2503728269523 0.102316667311152 no 3025 0.105581693031754 4309 6462614
SGTC_248 streptozotocin 5.23457 mM -1.25205062658095 0.102014161556546 no 3026 0.105275708482021 4364 5300 DNA alkylating agent.
SGTC_83 0170-0301 39.027 µM -1.25402059237996 0.101659809805695 no 3027 0.104917260374618 4329 3089716
SGTC_741 4582-0002 126 µM -1.25501318693767 0.101481604691513 no 3028 0.104736986457237 4351 2912688
SGTC_3041 9091929 49.47 µM -1.25510612448236 0.10146493083844 no 3029 0.104720118736121 4327 25236887
SGTC_1546 5-methoxyflavanone 78.7 µM -1.25732387016819 0.101067638553355 no 3030 0.104318191917983 4343 147795
SGTC_2492 derrusnin 100 µM -1.26177280997778 0.100274065928288 no 3031 0.10351527435956 4361 1715307 Part of coumarin class of compounds.
SGTC_695 3505-6186 243 µM -1.26361308979302 0.0999471420312113 no 3032 0.103184466500579 4324 1819379
SGTC_1239 0337-0584 35.4 µM -1.26420293398782 0.0998425217019668 no 3033 0.103078599015675 4410 914301 YML130C ERO1
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.26586077797379 0.0995488992711747 no 3034 0.102781465385532 4360 94937 An inhibitor of serotonin biosynthesis.
SGTC_2145 5634607 200 µM -1.26645113638714 0.0994444928129872 no 3035 0.102675806498909 4318 308662
SGTC_3151 9099821 49.47 µM -1.26853563730583 0.0990764835320114 no 3036 0.102303366267705 4286 17174189
SGTC_2549 cedrol 20.94 µM -1.27517945505854 0.0979101955452888 no 3037 0.101122865704261 4286 6708665 A sedative which affects the nervous system.
SGTC_651 3253-0966 34.4 µM -1.27713136479989 0.0975694678108827 no 3038 0.100777936642339 4355 781462
SGTC_1746 st038117 42 µM -1.27782537626936 0.0974485301176536 no 3039 0.100655502352954 4387 2898218
SGTC_1439 4092-1168 46 µM -1.27932473578906 0.0971876287813988 no 3040 0.100391362753726 4356 2886240
SGTC_1520 flindersine 88 µM -1.27951629299375 0.0971543331577205 no 3041 0.100357652922437 4394 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.27991311712816 0.0970853855809049 no 3042 0.100287846933746 4380 688664
SGTC_1929 genistein trimethyl ether 50.5 µM -1.28123485612571 0.0968559945106905 no 3043 0.100055593255109 4320 136420
SGTC_1909 st060837 51.5 µM -1.28186565493588 0.0967466582098644 no 3044 0.0999448889291057 4311 678937
SGTC_1296 1068-0102 11.9 µM -1.28703602201859 0.0958538934999406 no 3045 0.0990408664920776 4343 767053
SGTC_2216 7189485 200 µM -1.28758421324175 0.0957595940600168 no 3046 0.0989453688096905 4354 731273
SGTC_3129 9127257 49.47 µM -1.28967788516095 0.0954000702594029 no 3047 0.098581260528383 4300 837894
SGTC_839 0122-0028 230 µM -1.29037958426657 0.0952797975965754 no 3048 0.0984594485006956 4385 759448
SGTC_1885 st057546 99.9 µM -1.29118492905528 0.0951418974894991 no 3049 0.0983197798882965 4388 702008
SGTC_980 1473-0395 201 µM -1.29138551978079 0.0951075729864306 no 3050 0.0982850146028857 4240 768876
SGTC_3084 9116877 49.47 µM -1.29358194703476 0.0947323232472607 no 3051 0.0979049307686429 4306 27241325
SGTC_1608 st001473 40.5 µM -1.29412574330988 0.0946395868363226 no 3052 0.0978109953724711 4306 7292267
SGTC_373 0844-0104 25.9 µM -1.29780411857227 0.0940140509562025 no 3053 0.097177327011478 4381 5375804
SGTC_3075 9116269 49.47 µM -1.29828004115737 0.0939333401037552 no 3054 0.0970955611301964 4368 17015205 YNL244C SUI1
SGTC_1071 trifluoperazine 6.31 µM -1.30010219682306 0.0936247966909205 no 3055 0.0967829724232842 4417 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1116 jasmonic acid 1.58368 µM -1.30081048755246 0.093505064877863 no 3056 0.0966616656350887 4411 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2409 alverine citrate 63.97 µM -1.30329448537226 0.0930860553904835 no 3057 0.096237121541504 4429 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1553 gossypol 38.6 µM -1.30380564035816 0.0930000044041717 no 3058 0.0961499295108944 4250 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_226 1,3-diallylurea 8.28947 mM -1.30470690099678 0.0928484238893835 no 3059 0.0959963353548282 4305 74537 YKL182W FAS1
SGTC_1198 1612-1005 86.7 µM -1.30471265113396 0.0928474573766558 no 3060 0.0959953559876207 4437 6998509
SGTC_583 1488-1091 88.9 µM -1.30636532828614 0.0925699751086615 no 3061 0.09571417535356 4473 4303273
SGTC_2207 7258803 200 µM -1.30682708165838 0.0924925570946487 no 3062 0.0956357226787847 4382 3666799
SGTC_1699 st031318 29.054 µM -1.31167456578261 0.0916827125147556 no 3063 0.0948149809995251 4429 5340658
SGTC_156 3474-0145 5.642 µM -1.3117869722156 0.0916639958661308 no 3064 0.0947960109037853 4286 2265471
SGTC_414 piperonyl butoxide 100 µM -1.312291010865 0.091580103855667 no 3065 0.0947109819979596 4371 5794 A potent inhibitor of cytochrome P450.
SGTC_231 b-estradiol 524 µM -1.31265029007089 0.0915203402954801 no 3066 0.094650407638942 4340 450 A steroid.
SGTC_2037 5169046 200 µM -1.31322368879015 0.0914250193485487 no 3067 0.0945537919608191 4426 5718022
SGTC_2905 7799065 20.05 µM -1.31600013661628 0.0909645074806036 no 3068 0.0940869984077318 4261 1296806
SGTC_237 nikkomycin 200 µM -1.32051000260248 0.0902201556059681 no 3069 0.0933323993226988 4396 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1264 0783-0040 158 µM -1.32844860333518 0.0889208992027415 no 3070 0.0920149760470399 4300 2855798
SGTC_207 4185-0010 4.486 µM -1.3290917491782 0.0888162530524289 no 3071 0.0919088510194746 4469 3761753
SGTC_2046 4110841 106 µM -1.33185755842307 0.0883672736716205 no 3072 0.0914534998803469 4378 44119630 YMR134W ERG29
SGTC_1637 st007924 17.4 µM -1.33312164408837 0.0881626361466364 no 3073 0.0912459437947278 4306 683336
SGTC_3062 9077494 49.47 µM -1.33448457066239 0.0879423936819344 no 3074 0.0910225500866506 4348 16459633
SGTC_2163 5671233 125 µM -1.33460582309283 0.0879228197573183 no 3075 0.0910026955882617 4359 701023
SGTC_2097 5376186 200 µM -1.33586275280338 0.0877201034683723 no 3076 0.0907970686587579 4375 742755
SGTC_1431 4049-0260 9.09 µM -1.33776350483085 0.0874142148209628 no 3077 0.0904867710685654 4404 3854841
SGTC_1686 st019653 115.5 µM -1.33785769470324 0.087399077544487 no 3078 0.0904714150800282 4389 97252
SGTC_2344 7990960 76.95 µM -1.3399115924979 0.0870694814889204 no 3079 0.0901370444020971 4372 140813
SGTC_1984 st072354 53.1 µM -1.34043447422934 0.0869857212946857 no 3080 0.0900520670394032 4262 5762938
SGTC_134 0269-0018 6.916 µM -1.34232732256266 0.0866830100490056 no 3081 0.0897449440583618 4355 4378915
SGTC_3297 9117502 71.43 µM -1.34525825849976 0.0862158384257728 no 3082 0.0892709241570377 4414 7453720
SGTC_3195 9113082 49.47 µM -1.34766482009633 0.0858336586281581 no 3083 0.088883105981942 4402 17018038
SGTC_3257 9139206 32.98 µM -1.34889428529434 0.0856389004985421 no 3084 0.0886854620283772 4405 4910041
SGTC_1123 mangostin 811.285 nM -1.34955599306384 0.0855342172061801 no 3085 0.0885792240914738 4395 5281650 An antioxidant.
SGTC_32 0928-0142 34.1 µM -1.35037357011712 0.0854050075081043 no 3086 0.0884480921258867 4392 2244242
SGTC_75 0159-0059 199.013 µM -1.35632425291574 0.0844689642682446 no 3087 0.0874980110693959 4471 5377270
SGTC_1179 1021-1431 9.29 µM -1.36187748865199 0.0836024020895034 no 3088 0.0866182758112085 4430 2840958
SGTC_287 k060-0039 29.6 µM -1.37092199800007 0.0822053639633102 no 3089 0.0851996365229115 4446 5861974
SGTC_2099 5377090 177.372 µM -1.3737442009714 0.0817730586572918 no 3090 0.0847605547149488 4430 2243829
SGTC_991 3996-0057 64.7 µM -1.37464102603308 0.0816360423339742 no 3091 0.0846213814532289 4442 715343
SGTC_2305 7443522 69.23 µM -1.37661585548588 0.0813349395616732 no 3092 0.0843155230901988 4307 5415886
SGTC_1807 st050092 58.9 µM -1.37951062162023 0.0808950888779024 no 3093 0.0838686868206666 4438 5008496
SGTC_1797 st048695 56.8 µM -1.38625817838685 0.0798767928725086 no 3094 0.0828340411255172 4374 592262 YIL048W NEO1
SGTC_107 0358-0022 2.6945 µM -1.38823939399506 0.0795796498516783 no 3095 0.0825320801166157 4458 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2852 9023854 51.95 µM -1.38885658161642 0.0794872550248738 no 3096 0.0824381828019064 4446 19798528
SGTC_2593 nobiletin 86.24 µM -1.38938657883156 0.0794079776701169 no 3097 0.0823576146166727 4409 72344 An anti-infammatory.
SGTC_1108 betulinic acid 729.144 nM -1.39115944356247 0.0791432262004006 no 3098 0.0820885412515024 4413 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2860 9025725 38.96 µM -1.39276192518788 0.0789044945796306 no 3099 0.0818458978174349 4484 40546248
SGTC_1035 k081-0041 55.2 µM -1.39485107491482 0.0785940806838199 no 3100 0.0815303766437007 4446 731709
SGTC_3164 9100705 49.47 µM -1.39624907148426 0.0783868784814842 no 3101 0.0813197521263837 4442 17174235
SGTC_1278 0874-0585 172 µM -1.39744284191579 0.0782102734542766 no 3102 0.0811402217866967 4490 766306
SGTC_2537 larixol 68.93 µM -1.39765947015013 0.0781782580973066 no 3103 0.0811076752966462 4411 6708759
SGTC_2641 levomentholum 100 µM -1.39820444011453 0.0780977612721866 no 3104 0.0810258419120519 4433 16666
SGTC_3074 9116018 49.47 µM -1.39950089873245 0.077906515734613 no 3105 0.0808314145128301 4488 17027303
SGTC_1160 4092-0570 10.5 µM -1.40074570066642 0.0777232249013508 no 3106 0.080645065634141 4442 4994975
SGTC_385 1494-0393 12.4 µM -1.40418448198543 0.0772185828859008 no 3107 0.0801319607909998 4409 3090647
SGTC_544 k015-0020 52.4 µM -1.40439384200204 0.0771879398335224 no 3108 0.0801008018018176 4466 3008304
SGTC_1015 4130-4525 82 µM -1.4070393527989 0.0768015243347764 no 3109 0.0797078599587632 4447 1363237
SGTC_1967 st070177 51.4 µM -1.40823214490958 0.0766277814406415 no 3110 0.0795311703671042 4442 5729214
SGTC_1877 wortmannin 25 µM -1.41491476078012 0.0756599114543651 no 3111 0.0785467447960108 4470 312145 A covalent inhibitor of PI 3-kinase.
SGTC_596 1155-0152 116 µM -1.41834266922226 0.075167061586457 no 3112 0.0780453724291699 4464 280313
SGTC_1379 2144-0755 36.5 µM -1.42049685904319 0.0748585963460258 no 3113 0.0777315411831816 4490 5392327
SGTC_2057 5236571 38.335 µM -1.42067217199307 0.0748335352878783 no 3114 0.0777060430829899 4387 54684039 YBR257W POP4
SGTC_3024 9090631 49.47 µM -1.42595938634891 0.0740807296599791 no 3115 0.0769400328279791 4416 25236383
SGTC_3340 9146634 11.102 µM -1.42776597318583 0.0738248341452124 no 3116 0.076679614921618 4437 4907387
SGTC_2507 purpurin 79.67 µM -1.43070011120414 0.0734106660584623 no 3117 0.0762580906772782 4447 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2919 7978188 46.38 µM -1.43361976904896 0.0730003082206181 no 3118 0.0758403994348794 4463 2980291
SGTC_27 0485-0001 32.618 µM -1.43701609575763 0.0725251662082239 no 3119 0.0753567100472724 4452 2054479
SGTC_680 0417-1641 114 µM -1.44760829835425 0.0710585391667667 no 3120 0.0738633145176436 4487 2835990
SGTC_3087 9117406 49.47 µM -1.45007816391987 0.0707198517471938 no 3121 0.0735183617876144 4477 42546093
SGTC_2499 avocadenofuran 51.48 µM -1.45220111997797 0.0704297278336522 no 3122 0.0732228456910389 4434 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1554 st069299 38.7 µM -1.45388270084113 0.0702005725682502 no 3123 0.0729894148566056 4429 24207999
SGTC_865 0488-0499 301 µM -1.45509087946839 0.0700362839148322 no 3124 0.0728220518976191 4414 9634651
SGTC_2081 5214970 32.255 µM -1.45676594586275 0.0698089972124367 no 3125 0.0725904995646786 4403 2063512
SGTC_3238 9133470 49.47 µM -1.45767823838181 0.0696854489240433 no 3126 0.0724646264873968 4482 3534688
SGTC_1420 4'-methoxyflavone 42 µM -1.45980877331077 0.0693975743455557 no 3127 0.0721713183441772 4468 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3230 9131665 49.47 µM -1.46027041289503 0.0693353192248703 no 3128 0.0721078850964485 4482 15943720
SGTC_2911 7942208 15.64 µM -1.46214960188897 0.0690823421881212 no 3129 0.071850109385991 4487 1243384
SGTC_875 0709-0210 25.7 µM -1.46321230427147 0.06893959604496 no 3130 0.0717046475007089 4445 6251364
SGTC_82 0054-0107 293.755 µM -1.46516256354169 0.0686782215878675 no 3131 0.071438285356015 4443 3104697
SGTC_2460 5552655 174.22 µM -1.46683809733858 0.0684542768332467 no 3132 0.0712100516352468 4460 5401989
SGTC_1958 st076513 41.9 µM -1.46804467281454 0.0682933602828193 no 3133 0.0710460443468423 4411 732122 YGL099W LSG1
SGTC_2614 arthonioic acid 13.39 µM -1.47369410328953 0.067543796954476 no 3134 0.070281985619993 4348 6710684
SGTC_2876 9059903 25.97 µM -1.47456745362722 0.0674284908277612 no 3135 0.0701644351813398 4473 6916095
SGTC_191 3914-0123 66.505 µM -1.48374993908505 0.0662253426205484 no 3136 0.0689376361904295 4545 3144412
SGTC_3107 9121808 49.47 µM -1.48684633878019 0.0658234029005943 no 3137 0.0685276998031278 4449 662681
SGTC_2487 5918373 44.05 µM -1.48811662894194 0.0656590561273162 no 3138 0.0683600693968862 4541 2876279
SGTC_571 k831-0106 44.2 µM -1.49505374792098 0.0647671566167645 no 3139 0.0674502077330613 4380 4783639
SGTC_352 k048-0007 5.11 µM -1.49599449006851 0.0646469340583432 no 3140 0.0673275455129745 4426 6811911
SGTC_1499 4480-0877 67.3 µM -1.49681378390495 0.0645423733081591 no 3141 0.0672208593332816 4480 2861909
SGTC_2700 st077718 96.8 µM -1.49762954404397 0.0644383941118049 no 3142 0.067114763209623 4474 904970
SGTC_525 k781-2675 26.7 µM -1.49909044858643 0.0642525082083524 no 3143 0.0669250845622316 4438 3651118 YDL195W SEC31
SGTC_3346 9158254 43.5805 µM -1.51042854608138 0.062823982647985 no 3144 0.0654670546035332 4518 17639500
SGTC_2924 9010168 62.78 µM -1.51126581124334 0.0627194818845275 no 3145 0.0653603704400454 4497 2993929
SGTC_1806 st050005 60.3 µM -1.51445424823508 0.0623227664053031 no 3146 0.0649553346707865 4543 5194765
SGTC_785 1270-0111 65.3 µM -1.51550484918498 0.0621924768128537 no 3147 0.0648223016169379 4419 6741994
SGTC_29 0299-0004 12.984 µM -1.52379192587265 0.0611721956229238 no 3148 0.0637803485735967 4420 16871 A napthoquinone isolated from Swertia calycina.
SGTC_384 k007-0144 5.16 µM -1.53321037286582 0.0600285559409935 no 3149 0.0626120146507166 4458 6824886
SGTC_163 TUB2.036 7.546 µM -1.53676821287817 0.0596009259342878 no 3150 0.0621750400728998 4467 15992207 YJR013W GPI14
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.53810819738934 0.0594404884856372 no 3151 0.062011081009119 4536 23665772 A membrane-active detergent.
SGTC_1270 0831-1170 17.3 µM -1.54263708006263 0.0589007463285354 no 3152 0.0614594279986153 4532 6764716
SGTC_34 0469-0683 81.75 µM -1.54627867994635 0.0584695440956115 no 3153 0.0610186393290389 4499 3690923
SGTC_1357 1503-1303 39.5 µM -1.54672774906568 0.0584165419058951 no 3154 0.060964454433 4496 292895
SGTC_309 k408-0051 1.48 µM -1.54932856643429 0.0581103174805522 no 3155 0.060651378011492 4440 3640463
SGTC_2947 9072639 7.68 µM -1.54987745279407 0.0580458521918938 no 3156 0.0605854661665939 4469 16488146
SGTC_1784 st039334 36.3 µM -1.55189403398324 0.0578094923516659 no 3157 0.0603437903357257 4521 3496984
SGTC_1793 st048256 72.231 µM -1.55546329970962 0.0573930007116335 no 3158 0.0599178843240083 4497 672022
SGTC_1740 st038286 13.222 µM -1.55614633045982 0.0573135687749728 no 3159 0.0598366500652643 4525 716786
SGTC_2858 9025781 8.96 µM -1.55657436807368 0.0572638349534915 no 3160 0.0597857866563183 4365 4894980 YPL153C RAD53
SGTC_1884 5633444 25 µM -1.55853811521177 0.0570361017617203 no 3161 0.0595528699967832 4465 5724239
SGTC_3268 9137683 49.47 µM -1.56246719634192 0.0565825923173475 no 3162 0.0590889839241287 4591 1953228
SGTC_2871 9038510 12.99 µM -1.56345336302709 0.0564692124516088 no 3163 0.0589729985034335 4481 4945164
SGTC_709 3807-1509 243 µM -1.56630122896479 0.0561427974066772 no 3164 0.0586390567190179 4597 1886677 YPL242C IQG1
SGTC_2811 7967822 32.47 µM -1.56902104977933 0.0558324493209503 no 3165 0.0583215171389429 4546 2232244
SGTC_1657 st012939 43.4 µM -1.57485350408121 0.0551714950418291 no 3166 0.0576451315446094 4522 24207257
SGTC_2823 7987624 58.44 µM -1.57554095371413 0.0550939997176477 no 3167 0.0575658165731003 4481 2239440
SGTC_2158 5657123 3.6195 µM -1.57791036756909 0.0548275575431032 no 3168 0.0572931014364499 4528 2858827
SGTC_1460 k062-0059 9.15 µM -1.578504642938 0.054760890896025 no 3169 0.057224861169174 4418 1373085
SGTC_408 cantharidin 100 µM -1.58038074121957 0.0545508479586088 no 3170 0.0570098496521377 4521 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.5826650486051 0.0542959637442023 no 3171 0.0567489143209357 4487 676296 Flavone; oxidizing agent.
SGTC_2154 5570129 200 µM -1.58985593302914 0.0534997487789042 no 3172 0.0559336413328705 4586 673366
SGTC_1312 1218-2183 165 µM -1.59221787618014 0.053240249052207 no 3173 0.0556678789704393 4592 6744073
SGTC_49 0717-0965 32.132 µM -1.59369923038588 0.0530780068268592 no 3174 0.0555017083518381 4598 5889349 YGL099W LSG1
SGTC_1725 st036284 20.55 µM -1.60105020602384 0.0522786984019614 no 3175 0.0546828998079713 4560 707914
SGTC_679 0422-0091 41.4 µM -1.60604640713149 0.0517409137884511 no 3176 0.0541318569217531 4574 627384 YHR062C RPP1
SGTC_901 1112-0062 60.1 µM -1.60945211696403 0.0513768546930217 no 3177 0.0537587585737386 4539 1908457
SGTC_654 1124-0271 80.9 µM -1.61550907844463 0.0507344223572711 no 3178 0.0531002479717874 4553 5403748
SGTC_1996 st072960 66.8 µM -1.61758382900671 0.0505158404345641 no 3179 0.0528761581969684 4578 1719405
SGTC_2153 5569715 200 µM -1.62523637377112 0.0497160992232362 no 3180 0.0520561013990881 4574 2054701
SGTC_1422 4031-0024 15.5 µM -1.62731532732887 0.0495005888486058 no 3181 0.0518350721280648 4503 782427
SGTC_213 1246-0773 967 nM -1.63064399630409 0.0491570827068357 no 3182 0.0514827300005155 4588 6251622
SGTC_2014 4013930 200 µM -1.63170806174027 0.0490476775969173 no 3183 0.051370500476654 4536 64556
SGTC_2334 9017922 200 µM -1.63373304475267 0.0488400101995674 no 3184 0.0511574583040677 4566 3163164
SGTC_3029 9088683 49.47 µM -1.6345632412438 0.0487550746845341 no 3185 0.0510703193648581 4566 25236615
SGTC_805 3852-0218 479 µM -1.63558379804296 0.048650825649823 no 3186 0.0509633617673485 4546 6615355
SGTC_2849 9019321 12.99 µM -1.63573855785119 0.0486350326344339 no 3187 0.0509471580284039 4553 16489627
SGTC_2272 7805186 180 µM -1.63763563738832 0.0484417712648903 no 3188 0.0507488621426593 4564 2956062 YPR165W RHO1
SGTC_2187 6125751 200 µM -1.63800996441281 0.0484037100565532 no 3189 0.0507098075872445 4583 874498
SGTC_3176 9106582 49.47 µM -1.63807988117043 0.0483966036400961 no 3190 0.0507025156354934 4578 17018027
SGTC_314 1671-0008 2.74 µM -1.63914104823815 0.048288847857847 no 3191 0.0505919439545391 4436 3913060
SGTC_1562 morin hydrate 59.1 µM -1.64466749597447 0.0477307658389208 no 3192 0.0500191996763152 4564 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_181 1447-1644 8.07 µM -1.64784208483803 0.04741252658773 no 3193 0.0496925402303378 4522 534600
SGTC_1998 st075797 76.8 µM -1.65164831606421 0.0470332114774883 no 3194 0.0493031322090072 4562 24208315
SGTC_2623 humulene 100 µM -1.65386359489181 0.0468135675143302 no 3195 0.0490776155002287 4539 6187145 An anti-inflammatory.
SGTC_1571 st070080 73.4 µM -1.65639109137873 0.0465639730272193 no 3196 0.0488213220110938 4560 4315245
SGTC_3014 9081533 49.47 µM -1.65757967243875 0.0464469684372941 no 3197 0.048701167707539 4583 21367265
SGTC_3235 9132602 49.47 µM -1.65953259258057 0.0462552344300279 no 3198 0.0485042593239352 4555 4912240
SGTC_1065 prochlorperazine maleate 2.48 µM -1.66154323040739 0.0460584983421695 no 3199 0.0483021970447755 4607 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2689 tacrolimus 100 µM -1.66309725200568 0.0459069020478109 no 3200 0.0481464849460161 4554 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_57 miconazole 162.5 nM -1.66748981294043 0.0454805708787722 no 3201 0.0477085241891729 4413 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1660 st012960 28.1 µM -1.66932482523553 0.0453034145787233 no 3202 0.0475265114488071 4584 24207266
SGTC_426 0988-0037 14.6 µM -1.66975614600056 0.0452618545585804 no 3203 0.0474838100870151 4575 5383008
SGTC_892 0929-0076 29 µM -1.67134675263646 0.0451088563103976 no 3204 0.0473266034125349 4560 5751038
SGTC_3119 9125183 49.47 µM -1.67249114633747 0.0449990363124151 no 3205 0.0472137561399 4487 22695334
SGTC_2715 st079500 56.4 µM -1.67677083750931 0.0445902481452901 no 3206 0.0467936512179987 4573 28246688
SGTC_229 benomyl 22.8748 µM -1.68214243264518 0.0440814025989653 no 3207 0.0462706119464733 4591 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_661 1304-0007 33.6 µM -1.68270008770418 0.0440288458635375 no 3208 0.0462165823791592 4596 3117130
SGTC_1212 0520-0165 585 µM -1.68442522600518 0.0438665784213075 no 3209 0.0460497595100941 4608 5403258
SGTC_2991 9074669 71.4286 µM -1.69096479835083 0.0432558380364543 no 3210 0.0454217630152455 4531 17333109
SGTC_1563 conessine 56.1 µM -1.69764283029169 0.0426392717731395 no 3211 0.0447875969588941 4639 441082 An anti-amoebic, histamine inhibitor.
SGTC_1506 4226-2149 212 µM -1.7065893777308 0.0418244159914622 no 3212 0.0439492004462212 4591 991114
SGTC_3012 9080433 71.4286 µM -1.71093934013795 0.0414328002965009 no 3213 0.0435461556771442 4573 17688859
SGTC_2141 5621638 7.665 µM -1.71124838675941 0.0414050910770329 no 3214 0.0435176349094277 4597 2856238
SGTC_2566 crystal violet carbinol 226 nM -1.72126614499502 0.0405149993021451 no 3215 0.0426012699421172 4545 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.73080620564194 0.0396818534051294 no 3216 0.0417431673577408 4616 5024745
SGTC_963 1269-2853 151 µM -1.7346464766827 0.0393504343743112 no 3217 0.0414017209833255 4603 3668223
SGTC_400 oxethazaine 37.5 µM -1.73757221520748 0.0390994548214541 no 3218 0.041143109577995 4625 4621 A local anesthetic.
SGTC_95 0471-0001 561.058 µM -1.74884280253461 0.0381447788061506 no 3219 0.0401590978971067 4581 4015405
SGTC_128 0906-2981 13.371 µM -1.75102520785223 0.0379621331814825 no 3220 0.0399707839937696 4600 6740226
SGTC_399 oxolinic acid 75 µM -1.75506045078467 0.0376263030447118 no 3221 0.0396244841231346 4601 4628 A DNA gyrase inhibitor.
SGTC_2651 TUB2.036 5 µM -1.75636970121942 0.0375178642188231 no 3222 0.0395126514273653 4486 15992207 YFL037W TUB2
SGTC_1496 4469-0713 57.4 µM -1.76324661844217 0.0369524660253283 no 3223 0.0389294521325744 4625 746691
SGTC_988 1497-1057 103 µM -1.7829417567656 0.0353716379400941 no 3224 0.0372978924196551 4617 3533044
SGTC_374 0880-0231 82.3 µM -1.78831868767369 0.0349498306336789 no 3225 0.0368623032685714 4487 6833587
SGTC_1328 1441-0025 69.2 µM -1.79385169223186 0.0345200988540626 no 3226 0.0364184218412653 4658 4562601
SGTC_938 3126-1755 342 µM -1.79795398297538 0.0342042964265927 no 3227 0.0360921501834008 4619 1777771
SGTC_1649 st011737 51.3 µM -1.79951407486249 0.0340848225089553 no 3228 0.0359686997606066 4639 1761035
SGTC_2666 tannic acid 100 µM -1.80483870747701 0.0336796365731189 no 3229 0.0355499626737177 4608 16134267 A thiamine antagonist.
SGTC_1375 2910-0797 186 µM -1.81018922812692 0.0332764817415304 no 3230 0.0351332237464344 4624 742508
SGTC_1494 4358-1428 177 µM -1.82126317755338 0.0324546952105564 no 3231 0.0342834304735169 4658 1564571
SGTC_675 1309-0189 238 µM -1.82155944680315 0.0324329414262793 no 3232 0.0342609294553582 4639 4246530
SGTC_3025 9087895 49.47 µM -1.8331638601155 0.0315902966488729 no 3233 0.033389103293414 4635 17173641
SGTC_649 1123-0311 367 µM -1.83710880706992 0.0313079915273369 no 3234 0.0330969171409459 4541 693629 YIL048W NEO1
SGTC_3168 9103419 49.47 µM -1.85293126641332 0.0301966031402998 no 3235 0.0319461054815501 4690 16649256
SGTC_101 0490-5701 117.494 µM -1.85446811411696 0.0300904176438593 no 3236 0.0318361089221009 4534 4661669
SGTC_1395 3486-0190 4.35 µM -1.85833163082116 0.0298248422438143 no 3237 0.0315609673271406 4630 6748079
SGTC_3124 9127567 49.47 µM -1.86227846862939 0.0295555501552539 no 3238 0.0312819244065164 4607 17592030
SGTC_3008 9078912 71.4286 µM -1.86687731856915 0.0292443203946425 no 3239 0.0309593609675855 4648 16648731
SGTC_109 0132-0036 33.701 µM -1.87635571485788 0.0286114474946067 no 3240 0.0303032256422028 4591 67274 A color developer.
SGTC_743 1275-0778 158 µM -1.87736747303768 0.028544570338917 no 3241 0.030233873175051 4635 2849257 YMR203W TOM40
SGTC_1325 1431-0015 227 µM -1.88009963570255 0.0283646239722414 no 3242 0.0300472500649793 4642 1103340
SGTC_1340 1486-1359 257 µM -1.88154394944925 0.0282698802752916 no 3243 0.0299489813268348 4630 4309068
SGTC_1777 st045864 34.765 µM -1.88456240480767 0.0280727267860328 no 3244 0.0297444710335473 4669 4691462
SGTC_1656 st012921 11 µM -1.89593916398496 0.0273399037402609 no 3245 0.0289840447208243 4581 6732821
SGTC_677 0929-0063 136 µM -1.90027607944985 0.0270647781430842 no 3246 0.0286984493885235 4684 1539583
SGTC_318 1488-0629 67.2 µM -1.91157276674742 0.026358967592008 no 3247 0.0279655075778118 4708 3662576
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.91215123350169 0.0263232433107392 no 3248 0.0279283995092956 4638 1377
SGTC_2941 9056145 11.23 µM -1.92052044041821 0.0258109001446663 no 3249 0.0273960968948203 4624 2119517
SGTC_2587 piperic acid 92.2 µM -1.92293924905339 0.0256643902501132 no 3250 0.0272438399190147 4614 5370536
SGTC_3101 9120531 49.47 µM -1.93830976126335 0.0247495627083855 no 3251 0.0262927211104639 4627 24824904
SGTC_2064 5220758 200 µM -1.94749588295335 0.0242159949662044 no 3252 0.0257376564305601 4671 788518
SGTC_433 pimozide 108 µM -1.94750408678528 0.0242155228064195 no 3253 0.0257371651378974 4614 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2021 4019055 173 µM -1.95151983045459 0.0239853288129111 no 3254 0.0254976197901949 4451 44827708 YER133W GLC7
SGTC_2162 5663267 200 µM -1.95289070348473 0.0239071686254368 no 3255 0.0254162737587413 4675 6456493
SGTC_2736 butenafine 14.65 µM -1.95778345900396 0.0236299519572642 no 3256 0.0251277135797331 4633 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2643 anethole 100 µM -1.96905616027357 0.0230015322157352 no 3257 0.0244733211782256 4679 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2708 st078559 56 µM -1.9749169078065 0.0226804130018445 no 3258 0.0241387891596654 4652 17250902
SGTC_2368 9071271 200 µM -1.98416661911949 0.0221812989989595 no 3259 0.0236186342371592 4668 27209959
SGTC_868 0527-0199 213 µM -1.98670777822412 0.0220458123374332 no 3260 0.0234773946822487 4663 2849450
SGTC_3334 9142812 21.919 µM -1.98834063454862 0.0219591227275805 no 3261 0.0233870148032105 4665 45283678
SGTC_758 0868-0029 16 µM -1.9948696201513 0.0216153645832334 no 3262 0.0230285508485435 4612 762687
SGTC_116 0155-0182 31.788 µM -2.01204550723509 0.0207326859533871 no 3263 0.022107570063282 4561 771486
SGTC_2050 5263056 171 µM -2.01759118302564 0.0204542900991997 no 3264 0.0218169279463385 4664 763468 YGL055W OLE1
SGTC_2963 9082507 9 µM -2.01914456618809 0.0203768797314197 no 3265 0.0217360979729927 4657 16459611
SGTC_2935 9038016 29.96 µM -2.01936278221649 0.0203660252002235 no 3266 0.02172476343753 4641 6463195
SGTC_876 0720-0963 56.8 µM -2.02239439196106 0.0202157327323621 no 3267 0.021567811984343 4688 765861
SGTC_2828 7998861 71.43 µM -2.02686294115192 0.0199959190408483 no 3268 0.021338215696668 4701 2988188
SGTC_1631 benzylvanillin 81.9 µM -2.04425145319941 0.0191597529403019 no 3269 0.0204643562407647 4694 75506
SGTC_1282 0886-0010 32.4 µM -2.04653980978546 0.0190519574776479 no 3270 0.020351644937895 4703 2836211 YNL267W PIK1
SGTC_1658 st012944 20 µM -2.04743410475532 0.0190099711409056 no 3271 0.0203077403230569 4568 24207260
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -2.05357014878068 0.0187240064134494 no 3272 0.020008656904569 4698 6710655
SGTC_348 k064-0012 10.7 µM -2.05691472869999 0.0185696827205078 no 3273 0.0198472144745725 4673 5066323
SGTC_306 1672-3436 11.6 µM -2.05696350955311 0.0185674399388216 no 3274 0.0198448680327118 4710 6797378
SGTC_320 4092-0846 5.34 µM -2.07080232531465 0.0179404212234809 no 3275 0.0191886364245742 4663 1359356
SGTC_1211 1056-0033 32.3 µM -2.07517990461249 0.0177458764989299 no 3276 0.0189849321725282 4707 6741922
SGTC_860 0443-0016 25.1 µM -2.07604235564668 0.0177077611589173 no 3277 0.0189450168943273 4710 5337942
SGTC_1449 4112-4002 201 µM -2.08708792044935 0.0172257549227033 no 3278 0.0184400938911804 4716 2059539
SGTC_3165 9101544 49.47 µM -2.09906489723805 0.0167158149005471 no 3279 0.0179055901483542 4706 5002184
SGTC_1262 0737-0114 49.6 µM -2.09955235051708 0.0166953372030971 no 3280 0.0178841190536261 4712 765919
SGTC_2480 5767542 37.17 µM -2.10054356148296 0.0166537630558012 no 3281 0.0178405264152661 4657 2867358
SGTC_1840 st055363 71 µM -2.10062046954368 0.0166505410241115 no 3282 0.0178371478546773 4706 676033
SGTC_1495 4469-0029 237 µM -2.10171499725986 0.0166047440155864 no 3283 0.0177891245236881 4710 793680
SGTC_3271 9137798 49.47 µM -2.10516913792642 0.0164609227847559 no 3284 0.0176382938431219 4707 6498326
SGTC_1365 1672-3266 55.4 µM -2.10877193954939 0.0163120493176435 no 3285 0.0174821358998784 4718 6415873
SGTC_1075 aripiprazole 15.2 µM -2.11410942949196 0.0160936161005194 no 3286 0.017252961000938 4746 60795 An atypical antipschotic. YIL048W NEO1
SGTC_870 0573-2213 57.6 µM -2.13014922319275 0.0154522208342268 no 3287 0.0165796477991408 4716 3916321
SGTC_2771 fluoxetine 41.05 µM -2.1376294269382 0.0151606870131711 no 3288 0.0162734157225269 4702 3386 A selective serotonin reuptake inhibitor.
SGTC_1549 4'-methoxyflavonol 74.6 µM -2.1377151919712 0.0151573719942672 no 3289 0.0162699328708722 4725 97141
SGTC_1587 estradiol valerate 56.1 µM -2.14547262888996 0.0148600933604919 no 3290 0.0159575387853403 4747 13791 A steroid.
SGTC_2985 9022375 71.43 µM -2.15765322065381 0.014403430160986 no 3291 0.0154774017672503 4695 4939335
SGTC_1285 0929-0069 65.5 µM -2.16003384202347 0.0143156038679578 no 3292 0.0153850249134672 4730 1206237
SGTC_1191 1487-1166 10.6 µM -2.16382334076523 0.0141767524439258 no 3293 0.0152389550419667 4713 3955771
SGTC_2644 guaiazulene 100 µM -2.16397591403597 0.0141711863738924 no 3294 0.015233098990202 4740 3515 A coloring agent.
SGTC_921 1561-0023 372 µM -2.16761578781696 0.0140389562204428 no 3295 0.0150939657613988 4699 24050882
SGTC_742 0kpi-0133 140 µM -2.16947344148491 0.0139718817841398 no 3296 0.0150233792811795 4734 2728852
SGTC_993 3909-8757 62.7 µM -2.17847710626564 0.0136506863574796 no 3297 0.0146852674242646 4702 4288324 YLR208W SEC13
SGTC_2693 st077581 40.7 µM -2.18087344088747 0.0135662810057115 no 3298 0.0145963893193578 4679 25238761
SGTC_2975 9084847 53.72 µM -2.1818805479142 0.0135309426459656 no 3299 0.0145591749113028 4690 27211724
SGTC_859 0439-0102 54.6 µM -2.20125543565091 0.0128664036049261 no 3300 0.0138589729034137 4737 610143
SGTC_1572 epiandrosterone 68.9 µM -2.22257346314871 0.0121680135967394 no 3301 0.0131222876312041 4705 441302 A steroid.
SGTC_790 1575-0012 79.1 µM -2.24195465078635 0.0115618326589012 no 3302 0.0124821516919333 4727 378741 YLR208W SEC13
SGTC_922 1866-0035 480 µM -2.24546240259729 0.0114549703069809 no 3303 0.0123692316290543 4670 3156169
SGTC_3311 9131146 2.8755 µM -2.24625947582244 0.0114308077466996 no 3304 0.0123436963127976 4715 4900406 YPR165W RHO1
SGTC_1828 st055811 49 µM -2.26193842615428 0.0109644361084449 no 3305 0.0118506039155403 4733 5877589
SGTC_2316 5844804 197.44 µM -2.30147089181148 0.00986133803933567 no 3306 0.0106825144285117 4730 776813
SGTC_3141 9094609 49.47 µM -2.31339365377128 0.00954826007934434 no 3307 0.0103505028464424 4704 25236309 YDL196W YDL196W
SGTC_3160 9100216 49.47 µM -2.31741102863571 0.00944474357354813 no 3308 0.0102406760718414 4750 17191039
SGTC_986 1493-0483 84 µM -2.35398523396112 0.00854658901442103 no 3309 0.00928667443554735 4730 40079
SGTC_1330 1469-0054 61.8 µM -2.36485898271915 0.00829443342339207 no 3310 0.00901846868399075 4720 7102664
SGTC_1034 k072-0165 12.7 µM -2.36769934619819 0.00822965299807796 no 3311 0.0089495372859091 4750 5835461
SGTC_2006 4011487 200 µM -2.36948302109214 0.00818920011559494 no 3312 0.00890648647606035 4698 45595294
SGTC_2367 9070478 135.38 µM -2.37062686356391 0.00816335035328723 no 3313 0.0088789742643958 4723 572802
SGTC_3126 9127922 49.47 µM -2.37747916049016 0.00800999093613006 no 3314 0.008715713961431 4699 45595682
SGTC_407 eburnamonine 100 µM -2.41134631018033 0.00728863123806291 no 3315 0.00794687444119138 4677 3195
SGTC_131 0141-0277 33.849 µM -2.42888640381657 0.00693804342331172 no 3316 0.0075726383942829 4717 1547771
SGTC_946 3434-1334 87.4 µM -2.43936605028955 0.00673575889629767 no 3317 0.00735652808202572 4729 4047976
SGTC_308 4092-1169 104 µM -2.45281010184225 0.00648389538687458 no 3318 0.00708725727764515 4730 2268590 YDL196W YDL196W
SGTC_2957 9076800 11.52 µM -2.46803996898304 0.00620867159431189 no 3319 0.00679275746934319 4722 16459615
SGTC_431 k089-0097 107 µM -2.47648199185017 0.00606061359336008 no 3320 0.00663421591929655 4505 5499420
SGTC_2556 citropten 84.59 µM -2.49027894396207 0.00582536837146633 no 3321 0.00638214356649584 4734 2775 A potential DNA crosslinker.
SGTC_3328 9140624 29.0385 µM -2.50338939839094 0.00560937158054259 no 3322 0.0061505060427409 4752 4904392
SGTC_2752 diclazuril 33.15 µM -2.52028024636276 0.00534159201458289 no 3323 0.00586307162951721 4699 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1321 1326-2144 215 µM -2.52636805021552 0.00524790243533583 no 3324 0.00576243361576898 4757 3513030
SGTC_1824 st053723 68.6 µM -2.54843154454604 0.00492048310811434 no 3325 0.00541042607945452 4775 675225
SGTC_3324 9138759 60.749 µM -2.57773664650386 0.00451378704488352 no 3326 0.00497248796621972 4755 45595710
SGTC_339 3091-4833 71.4 µM -2.58380399448843 0.0044334345482312 no 3327 0.00488586549120161 4629 3240077
SGTC_1642 st009582 77.7 µM -2.59261167617333 0.00431906404984178 no 3328 0.00476251256987114 4776 6739311
SGTC_2586 curcumin 80 µM -2.62265012984703 0.00394857912698768 no 3329 0.00436244091808406 4709 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3145 9085516 49.47 µM -2.66727060938152 0.00345068632677982 no 3330 0.00382350358449523 4752 25236195
SGTC_2583 asiatic acid 100 µM -2.69988804015366 0.00312321591671088 no 3331 0.00346814070566228 4751 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2692 st077426 47.7 µM -2.79065301842305 0.00235401595052686 no 3332 0.00263009147210596 4772 25238571
SGTC_658 3253-0951 102 µM -2.79779905984282 0.00230143319860632 no 3333 0.00257260554294179 4783 1184878
SGTC_3286 9117135 37.221 µM -2.83354429526008 0.00205403488571005 no 3334 0.00230174637326087 4755 3438150
SGTC_688 0527-0193 473 µM -2.8344295453787 0.00204822644866465 no 3335 0.00229537897475013 4786 4007154
SGTC_1448 4255-0083 152 µM -2.94243069976327 0.00144183573411456 no 3336 0.00162823331542812 4797 5399660
SGTC_2642 cholecalciferol 100 µM -2.97249888704251 0.00130500925215917 no 3337 0.00147693140554137 4795 9821465 A vitamin D precursor, similar to steriods.
SGTC_2319 6033012 152.6 µM -2.99546498440198 0.0012086145209402 no 3338 0.00137013380637979 4782 847246
SGTC_3329 9141233 27.5565 µM -3.07457878579083 0.000924307632636391 yes 3339 0.00105400018103292 4785 4909101 YNL103W MET4
SGTC_2675 theaflavin digallate 100 µM -3.12070108582206 0.000788349368900927 yes 3340 0.000902105349552049 4778 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -3.12864656111257 0.000766877758700229 yes 3341 0.000878067030916138 4790 688761
SGTC_2994 9053520 71.4286 µM -3.15921523146687 0.000689195703476413 yes 3342 0.00079097307265456 4786 4647384
SGTC_2981 9013952 38.96 µM -3.25922839995761 0.000482915804866304 yes 3343 0.000558578449801197 4768 2996344
SGTC_2976 9009005 19.48 µM -3.26646734139049 0.000470467000665573 yes 3344 0.0005444918401144 4787 2993148
SGTC_2925 9010536 32.5 µM -3.29414285431569 0.000425563784403068 yes 3345 0.000493611558632365 4781 2994177
SGTC_2551 apiole 73.87 µM -3.33058455079747 0.000372489233054905 yes 3346 0.000433319198779803 4789 10659 A possible DNA adduct former.
SGTC_953 1188-0045 9.7 µM -3.35576308561526 0.000339483793146101 yes 3347 0.00039573168963949 4780 6144426
SGTC_2144 5628481 200 µM -3.37638694719137 0.000314496711883418 yes 3348 0.000367222740453066 4804 2818399
SGTC_877 0771-0151 33.1 µM -3.4386861371839 0.000249022431046104 yes 3349 0.000292272261876389 4803 6166523
SGTC_1376 2910-0861 41.3 µM -3.46464852335321 0.000225689291359928 yes 3350 0.000265462438508711 4794 1112859
SGTC_2624 nerol 100 µM -3.52332645234512 0.000180260669147351 yes 3351 0.000213083046224873 4784 637566 A natural product oil.
SGTC_3208 9114115 49.47 µM -3.53327164485302 0.000173465905077772 yes 3352 0.000205225250629163 4780 650895
SGTC_1569 carminic acid 40.6 µM -3.55784260210058 0.00015769174097857 yes 3353 0.00018695662245751 4804 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2338 7999974 200 µM -3.6594607507681 0.000105651293859158 yes 3354 0.000126373274641539 4793 315925
SGTC_690 glyoxal 20.3 µM -3.85417011212917 4.76922447101139e-05 yes 3355 5.80614192134487e-05 4765 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2980 9014342 25.29 µM -3.87791838823511 4.3173916232389e-05 yes 3356 5.26770222915265e-05 4796 2996599