SGTCid condition conc unit YMR173W-A|YMR173W-A.score YMR173W-A|YMR173W-A.strain.pval YMR173W-A|YMR173W-A.strain.significant YMR173W-A|YMR173W-A.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2002 4023503 131 µM 7.61782935795437 1.56461581700419e-13 yes 1 1.28988511275256e-14 3 4736863 YCR052W RSC6 SGTC_982 1491-0518 27.5 µM 6.22960328890877 1.28493882824357e-09 yes 2 2.33808886245602e-10 1 3091256 SGTC_350 k064-0020 19.8 µM 5.15121210573719 4.27404780033344e-07 yes 3 1.2940414065332e-07 10 2790705 SGTC_971 1315-0384 26.7 µM 5.12733096269391 4.8038196176843e-07 yes 4 1.4693931807066e-07 5 6769120 SGTC_3295 9122362 53.5725 µM 5.00429047591725 8.70077592933709e-07 yes 5 2.80340789736789e-07 3 4730473 SGTC_609 0986-0026 86.3 µM 4.67449722921 4.00170479649167e-06 yes 6 1.47337306977631e-06 17 2848610 SGTC_346 4513-0042 7.16 µM 4.5803906532742 6.07681590806548e-06 yes 7 2.32054108923268e-06 25 2827372 SGTC_1049 3226-0134 66 µM 4.47380364004845 9.66200932096338e-06 yes 8 3.84201555549511e-06 19 5702385 SGTC_1045 1348-1485 165 µM 4.43324386147515 1.14963637104198e-05 yes 9 4.64128855473834e-06 16 6810614 SGTC_2828 7998861 71.43 µM 4.30491040627159 1.97369654445045e-05 yes 10 8.35266646415831e-06 10 2988188 SGTC_158 k038-0087 26.446 µM 4.26726580567223 2.30642001118737e-05 yes 11 9.89416657225954e-06 121 X158 SGTC_3074 9116018 49.47 µM 4.24059058099711 2.57367671076785e-05 yes 12 1.11466223287281e-05 15 17027303 SGTC_480 am 92016 50 µM 4.21733719231123 2.83035020392222e-05 yes 13 1.23602090409333e-05 9 2129 K+ channel blocker. SGTC_2012 4023501 200 µM 4.0935506475684 4.65752039237323e-05 yes 14 2.12408614220922e-05 26 3477460 SGTC_471 1-acyl-paf 4 µM 4.09187196276111 4.68865361227714e-05 yes 15 2.13952452042765e-05 29 16759367 SGTC_1074 carmofur 3.8 µM 3.95988495933989 7.85577324044581e-05 yes 16 3.74929386322709e-05 20 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2762 leflunomide 42.06 µM 3.93110072566694 8.77388708826109e-05 yes 17 4.22789169798793e-05 29 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2698 st077697 67.5 µM 3.86900750509191 0.000111089920031361 yes 18 5.46396393794722e-05 18 3154499 SGTC_1451 4152-0210 104 µM 3.81675124231203 0.00013514200590342 yes 19 6.7610188414758e-05 32 659563 SGTC_165 k038-0023 64.381 µM 3.77107117318955 0.000160084254780826 yes 20 8.12741498610314e-05 89 46368543 SGTC_2893 9048488 25.97 µM 3.768612201081 0.000161542170041391 yes 21 8.20788466934894e-05 26 6467338 SGTC_462 ag-879 158 µM 3.72099492209551 0.000192344678761992 yes 22 9.92197145162493e-05 37 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2991 9074669 71.4286 µM 3.68860536651842 0.000216344986598672 yes 23 0.000112743322092168 77 17333109 SGTC_538 2922-0838 53.3 µM 3.67352431335755 0.000228448976405497 yes 24 0.000119613951339164 39 777039 SGTC_2328 6201408 200 µM 3.67219516662265 0.000229545504463124 yes 25 0.00012023795784414 27 2890418 SGTC_1883 5-benzylidenerhodanine 20 µM 3.57752435228665 0.000321572191499202 yes 26 0.000173431956053471 90 1273210 SGTC_1447 4239-0816 81.9 µM 3.51171214849842 0.000404642408516419 yes 27 0.000222614974937354 46 1341554 SGTC_2564 betulinic acid 100 µM 3.49225505072684 0.000432775995062542 yes 28 0.000239480334279987 45 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_3212 9128307 49.47 µM 3.41109951364628 0.000570808949333182 yes 29 0.000323507363479459 72 27243542 SGTC_2850 9015429 58.44 µM 3.40609444232367 0.000580530079942004 yes 30 0.000329496892688787 29 6457570 SGTC_1194 1488-0194 225 µM 3.39178868702329 0.000609165511459181 yes 31 0.000347189851880986 54 1391452 SGTC_3235 9132602 49.47 µM 3.34082241270932 0.000722120931449536 yes 32 0.000417653165035969 48 4912240 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 3.34006193308219 0.000723943845807247 yes 33 0.000418798542309104 51 6708561 SGTC_954 1189-0853 2.85 µM 3.32748999110698 0.000754700757893669 yes 34 0.000438160685389574 63 2828194 SGTC_1922 5578187 25 µM 3.30924414792482 0.000801484055350091 yes 35 0.000467741112368539 60 1350412 SGTC_536 3852-0578 10.6 µM 3.29724588995666 0.00083368775454099 yes 36 0.000488189904949997 54 2869208 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 3.26861736739896 0.000915394608179777 yes 37 0.000540371721183096 61 5357218 A potent inhibitor of glutathione S-transferases. SGTC_901 1112-0062 60.1 µM 3.18795458439183 0.00118678661621715 no 38 0.000716415196025799 28 1908457 SGTC_1107 amlodipine 47 µM 3.17922295288369 0.00122020818191301 no 39 0.000738352296287199 69 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_3080 9117754 49.47 µM 3.15784815141546 0.00130568982839065 no 40 0.000794691620908511 50 9550191 SGTC_557 1315-0110 16.2 µM 3.15456300206361 0.00131930273999175 no 41 0.000803693344507252 55 6833801 SGTC_3316 9136639 10.545 µM 3.13075210955302 0.00142191295234635 no 42 0.000871796347286118 42 4903665 SGTC_160 3453-0671 289.699 µM 3.12125049290199 0.00146485485047866 no 43 0.000900423899919159 81 5322268 SGTC_2034 5197015 53.07 µM 3.03102182262282 0.0019356697336832 no 44 0.00121863815904936 60 780676 SGTC_2154 5570129 200 µM 3.0304279834817 0.00193917887841793 no 45 0.0012210370903447 61 673366 SGTC_519 k048-0011 62.8 µM 2.99749093073267 0.00214310170973096 no 46 0.00136105979032625 63 6836379 SGTC_2705 st078069 42.8 µM 2.99574396249006 0.00215444207222801 no 47 0.0013688810181471 44 1530061 SGTC_2446 5162541 200 µM 2.98232793793627 0.00224336110460094 no 48 0.00143032698172014 34 1549321 SGTC_1017 4239-0030 168 µM 2.97428083865821 0.00229827825941985 no 49 0.00146838078958576 78 1149593 SGTC_416 estradiol valerate 100 µM 2.96077310344521 0.00239320407636578 no 50 0.00153433959778814 45 13791 A steroid. SGTC_3120 9124077 49.47 µM 2.9243616350718 0.00266701401507927 no 51 0.00172581745751706 50 18774327 YGL155W CDC43 SGTC_2767 sibutramine 71.45 µM 2.89732395641697 0.0028883060343326 no 52 0.00188180448727701 68 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2058 5236698 133 µM 2.87819137988606 0.00305476001619353 no 53 0.00199981207967593 82 766665 SGTC_1435 4092-0789 56.7 µM 2.86392851771601 0.00318441580003378 no 54 0.00209211212482903 53 2248285 SGTC_1130 3454-2858 15.9 µM 2.83914543911622 0.00342152792471418 no 55 0.00226172671904341 150 715628 YIL048W NEO1 SGTC_598 3937-0236 20.2 µM 2.83227032709343 0.00349005804254082 no 56 0.0023109378064387 95 1379313 SGTC_2588 indole-3-carbinol 100 µM 2.79239623961131 0.00391238284707359 no 57 0.00261596221827293 126 3712 Induces cell cycle arrest. SGTC_1096 rimcazole 32.2 µM 2.78576596750145 0.00398688518113439 no 58 0.00267007055687714 56 18528119 A dopamine reuptake inhibitor. SGTC_2136 5328288 199.296 µM 2.77860019839906 0.00406883098748082 no 59 0.00272968364865933 66 262395 SGTC_1617 st002906 78 µM 2.77129944676222 0.00415386770156216 no 60 0.0027916527362957 92 5150859 SGTC_2663 amphotericin b 100 µM 2.76681661031502 0.0042068668429354 no 61 0.00283032942763839 56 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2501 sodium tetradecyl sulfate 13.37 µM 2.76314333631712 0.00425074475139621 no 62 0.00286238101523637 111 23665772 A membrane-active detergent. SGTC_3073 9114972 49.47 µM 2.75992757697038 0.00428949302785865 no 63 0.00289070882729147 65 41905075 SGTC_2596 sinensetin 100 µM 2.74560397747673 0.00446594793458316 no 64 0.00301998122053866 90 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 2.74012773738134 0.00453510555986357 no 65 0.00307076551245537 77 4213774 SGTC_208 k072-0098 12.366 µM 2.73877586929455 0.00455232433252645 no 66 0.00308341993235843 134 5948901 SGTC_2132 5317594 122.667 µM 2.7355200923342 0.00459403299847201 no 67 0.00311408919767342 77 794577 SGTC_2413 inermin 26.06 µM 2.71525846020865 0.0048613497509398 no 68 0.00331120322736316 137 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_427 1354-0053 47.3 µM 2.71463205613076 0.00486983057606387 no 69 0.00331747208001784 91 6813657 SGTC_505 gw-5074 63.9 µM 2.70574375872612 0.00499159743263151 no 70 0.00340758052583323 121 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_20 0481-0013 4.944 µM 2.66917051564476 0.0055216595125076 no 71 0.00380194181683017 97 182045 SGTC_194 1486-1323 56.904 µM 2.66724067328603 0.00555096925171677 no 72 0.00382384420037063 79 5178754 SGTC_1342 1486-1464 234 µM 2.66132313466978 0.00564170613264608 no 73 0.00389171101660496 84 3253938 SGTC_74 000s-0487 160.283 µM 2.65952494555213 0.00566953845264702 no 74 0.00391254675367515 92 677548 SGTC_432 NS 1619 61.3 µM 2.64661731139774 0.00587292585344972 no 75 0.00406506502348792 114 4552 A K+/calcium channel activator. SGTC_265 mycophenolic acid 32.932 µM 2.62455854462189 0.00623552281288252 no 76 0.00433806877712425 98 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1971 st069429 63.5 µM 2.61382885713596 0.00641895749865208 no 77 0.00447669364129792 76 1246522 YGL099W LSG1 SGTC_2408 sulbentine 18.36 µM 2.60135349652994 0.00663822633170229 no 78 0.00464283583804793 137 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1962 st076595 64.5 µM 2.58369143366479 0.00695997496725605 no 79 0.00488746018074702 126 279619 SGTC_1510 1123-0200 71.5 µM 2.5720547178265 0.00717941185131443 no 80 0.00505484560095902 157 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1708 st033234 31.827 µM 2.56500279363684 0.00731534172954464 no 81 0.0051587487154562 88 674664 SGTC_2049 5262831 67.185 µM 2.55438122048304 0.00752436109833044 no 82 0.00531883587189956 126 763417 SGTC_541 4513-1321 94 µM 2.55409023212074 0.00753016067675669 no 83 0.00532328311638572 107 747515 SGTC_2883 9059145 45.46 µM 2.54348894548379 0.0077441532747467 no 84 0.0054875764868947 70 16476510 SGTC_264 promethazine 12.5 mM 2.53999509397369 0.00781584175565756 no 85 0.00554270119220676 187 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2353 9059630 146.67 µM 2.53888393632305 0.00783876305749134 no 86 0.0055603354398644 72 4779114 SGTC_93 0109-0045 59.227 µM 2.53384341559132 0.00794348465370697 no 87 0.00564095663207167 142 88733 SGTC_2805 7950783 58.44 µM 2.51030425577397 0.0084489884035452 no 88 0.00603135891380977 127 1178958 YDL195W SEC31 SGTC_3029 9088683 49.47 µM 2.50305573982293 0.0086102345037617 no 89 0.00615630755196433 116 25236615 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 2.49367396479675 0.00882293967139338 no 90 0.00632143068925809 154 551469 SGTC_518 1021-0119 62.6 µM 2.4792138490939 0.00915980289520802 no 91 0.00658361676450212 153 1097762 SGTC_645 0845-0943 5.41 µM 2.47499355643021 0.00926021811093534 no 92 0.00666192898451842 95 1885106 SGTC_1952 st077036 64.1 µM 2.47141648011792 0.00934608196154576 no 93 0.0067289491624187 137 2937007 SGTC_3007 9078383 71.4286 µM 2.46098482484896 0.00960047214699493 no 94 0.00692781132187163 120 6496995 SGTC_13 0199-0087 65 µM 2.45841917030154 0.0096639588445079 no 95 0.006977509327431 90 4589825 SGTC_2783 7738165 71.43 µM 2.44591662714705 0.00997860972537389 no 96 0.00722422036670995 116 17201110 SGTC_592 k241-0073 46.5 µM 2.44134336555252 0.0100959187452863 no 97 0.00731636725776426 115 4230158 SGTC_1872 amphotericin b 148 nM 2.43942888266185 0.0101453834771036 no 98 0.00735524892422779 124 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2033 5192550 145 µM 2.43489872905741 0.0102632725005598 no 99 0.00744797902287575 106 182073 SGTC_356 1634-0012 32.5 µM 2.43045893181412 0.0103799675073332 no 100 0.00753985745822905 130 735457 SGTC_989 1501-0895 10.3 µM 2.39723944732159 0.0112903946114507 no 101 0.00825956237237823 82 2830112 SGTC_2534 helenine 20.12 µM 2.37792807617874 0.0118509314969562 no 102 0.00870511072422103 98 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_17 0960-0276 49.807 µM 2.37451651061784 0.0119524265230874 no 103 0.0087859751583596 177 6821114 SGTC_3242 9133940 49.47 µM 2.36697332571564 0.01217951806449 no 104 0.00896711266718103 125 17248444 SGTC_957 1187-1561 14.1 µM 2.34601791455595 0.01283011924915 no 105 0.00948759770848475 152 1538454 SGTC_2892 9047358 58.44 µM 2.34416173675417 0.0128891711716722 no 106 0.00953494992712236 87 6466771 SGTC_1902 st060212 70.5 µM 2.34102351140907 0.0129895445009186 no 107 0.00961547800761216 132 688944 SGTC_2701 st077767 14.721 µM 2.33878840060482 0.0130614439300311 no 108 0.00967319366755464 183 5721188 SGTC_2381 9035592 200 µM 2.33376265361371 0.0132243704593568 no 109 0.00980407667696057 135 4749657 SGTC_1391 3442-0225 151 µM 2.32970458499634 0.0133572048416367 no 110 0.00991088502674666 116 5227075 SGTC_1244 0416-0015 52.5 µM 2.31787506779237 0.0137510205006402 no 111 0.0102280559085697 169 96201 SGTC_2926 9010726 65.15 µM 2.3170772215311 0.0137779384225513 no 112 0.0102497627973616 161 2994293 SGTC_1221 2958-7315 257 µM 2.31536039900899 0.0138360151408943 no 113 0.0102966084262773 131 4562705 SGTC_204 PMA1.184 62.41 µM 2.30627608446519 0.0141468461318896 no 114 0.0105476052902923 159 2252213 YGL008C PMA1 SGTC_785 1270-0111 65.3 µM 2.30561729773678 0.0141696194988187 no 115 0.0105660129400659 172 6741994 SGTC_2280 7785178 200 µM 2.30560062954152 0.0141701961052547 no 116 0.010566479041289 117 2954328 SGTC_1631 benzylvanillin 81.9 µM 2.30432226899773 0.0142144789771223 no 117 0.0106022798982273 159 75506 SGTC_187 1488-2104 32.728 µM 2.30341146981567 0.014246102071244 no 118 0.0106278515088442 163 2852859 SGTC_2996 9066192 71.4286 µM 2.30151628245438 0.014312097567262 no 119 0.0106812330568926 191 6472854 SGTC_2643 anethole 100 µM 2.29938027120763 0.0143867946455672 no 120 0.0107416776186859 150 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1980 st071811 45.7 µM 2.29768142939947 0.0144464431782198 no 121 0.0107899636327827 138 4974850 SGTC_2864 9034755 47.6 µM 2.29240135289517 0.0146331945787262 no 122 0.0109412470172385 147 4930451 SGTC_661 1304-0007 33.6 µM 2.28965280906672 0.0147312274851201 no 123 0.0110207255371044 139 3117130 SGTC_1415 3966-0071 78.1 µM 2.27970433921575 0.0150907990737312 no 124 0.0113126148920831 112 2893185 SGTC_1747 st037496 66.6 µM 2.27654419934263 0.0152065844500052 no 125 0.0114067291624628 164 723305 SGTC_1687 st020778 55.3625 µM 2.27006712505527 0.0154462868517973 no 126 0.0116017553069769 351 4259299 SGTC_3301 9125354 19.7965 µM 2.26041431386092 0.0158095325465186 no 127 0.0118977744766914 126 41905162 SGTC_2347 9049783 174.81 µM 2.25770506566115 0.0159127918437768 no 128 0.0119820266057058 202 6467988 YPL169C MEX67 SGTC_228 caffeine 993.056 µM 2.2560298797528 0.015976928146343 no 129 0.0120343799583905 110 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1992 st073643 23.3 µM 2.25290046668661 0.0160973348670022 no 130 0.0121327127217431 119 3161292 SGTC_1200 1643-0193 18.4 µM 2.25083197474638 0.0161773479429033 no 131 0.0121980907697024 167 5403974 SGTC_2728 chlorpromazine 9.18 µM 2.24242248685501 0.0165061604588318 no 132 0.0124670399104789 82 2726 A thorazine and dopamine antagonist. SGTC_855 0428-0020 25 µM 2.23732240493894 0.0167083484297768 no 133 0.0126326379517805 134 6812414 SGTC_2857 9024691 58.44 µM 2.22572207325726 0.0171761367154156 no 134 0.0130164016518404 170 16478292 SGTC_1197 1601-0112 267 µM 2.21838255455871 0.0174778497474209 no 135 0.0132643797947318 196 7350313 SGTC_1424 4048-1941 275 µM 2.21054134791104 0.017805174215372 no 136 0.0135338070991994 178 X1424 SGTC_1742 st038235 28.8875 µM 2.20478561787816 0.018048757645545 no 137 0.0137345708709851 266 564103 YBR002C RER2 SGTC_428 3448-4153 16.5 µM 2.19902873421183 0.018295225962561 no 138 0.0139379396044221 180 3834874 SGTC_1984 st072354 53.1 µM 2.19488980222169 0.0184741921116109 no 139 0.0140857517595054 134 5762938 SGTC_3326 9140064 16.379 µM 2.18285179223228 0.0190032080400913 no 140 0.0145233630694723 162 1868434 SGTC_2478 5763493 32.33 µM 2.17759287511151 0.0192383259033043 no 141 0.0147181802326113 156 1365576 YLR208W SEC13 SGTC_1109 tnp00067 928.257 nM 2.1674006650862 0.0197010476178526 no 142 0.0151021583033647 152 676295 SGTC_3094 9117742 49.47 µM 2.16075799774086 0.0200076799571538 no 143 0.0153570190827013 210 17149698 SGTC_937 3122-0005 46.7 µM 2.1584143634168 0.0201168263647637 no 144 0.0154478149892973 197 759535 SGTC_272 doxorubicin 8.13 µM 2.14822903475962 0.0205970559446521 no 145 0.0158477826173004 221 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2638 epoxomicin 18 µM 2.13932953871793 0.0210245752721575 no 146 0.0162044945152528 185 9915668 A protesome inhibitor. SGTC_413 propylparaben 100 µM 2.1391519689349 0.0210331813140528 no 147 0.0162116813413803 158 7175 A pharmaceutical preservative. SGTC_942 3253-1115 227 µM 2.13410454647887 0.0212790576677012 no 148 0.0164171119041356 186 46497897 SGTC_1089 terbinafine 2.25 µM 2.1206821404889 0.0219447608084994 no 149 0.0169742802288034 170 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2284 7945075 39.21 µM 2.11916752560357 0.0220209726665741 no 150 0.0170381558412338 216 1245402 SGTC_1513 0337-0559 19 µM 2.11239942747796 0.0223642629139653 no 151 0.0173261020368901 202 775073 SGTC_695 3505-6186 243 µM 2.10981393976469 0.0224965898601328 no 152 0.0174371926446497 183 1819379 SGTC_1503 4585-0012 61.3 µM 2.10250733377423 0.0228741208262961 no 153 0.0177544289515892 174 2922052 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 2.10246274696673 0.0228764409037905 no 154 0.0177563798262461 191 16486 A toxic proline analog. SGTC_3087 9117406 49.47 µM 2.09406866380698 0.0233167737291602 no 155 0.0181269320250714 180 42546093 SGTC_595 3909-8003 73.7 µM 2.0875474312429 0.0236637656699977 no 156 0.0184193391152054 194 699517 SGTC_798 1287-0182 476 µM 2.07025719720223 0.0246048491782034 no 157 0.0192141327820295 235 1649755 SGTC_2758 dehydroepiandrosterone 69.35 µM 2.06914263051329 0.0246665760761437 no 158 0.0192663521655948 220 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_578 3460-0051 92 µM 2.06650265918601 0.0248133013811441 no 159 0.0193905207890029 213 2876744 SGTC_1909 st060837 51.5 µM 2.0615028733514 0.0250931875960042 no 160 0.0196275448147082 232 678937 SGTC_271 rotenone 740 µM 2.04507520169333 0.026031498665687 no 161 0.0204237223383539 232 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2549 cedrol 20.94 µM 2.03536712227509 0.0265996724165835 no 162 0.0209069734595954 163 6708665 A sedative which affects the nervous system. SGTC_679 0422-0091 41.4 µM 2.03449608609925 0.0266511531840647 no 163 0.0209508014103487 249 627384 YHR062C RPP1 SGTC_1776 st049249 45.9 µM 2.0266551375758 0.0271183331990205 no 164 0.0213488467434146 236 1822314 SGTC_1235 benzylparaben 21.5 µM 2.02460057996006 0.0272418716911027 no 165 0.0214541973326225 188 7180 SGTC_1515 3460-0031 42.1 µM 2.02304293808915 0.0273358437159873 no 166 0.0215343603965291 162 2876596 SGTC_640 3381-0960 37.1 µM 2.01833304373785 0.0276216361725447 no 167 0.0217782937616638 201 1745025 SGTC_1264 0783-0040 158 µM 2.01139095191298 0.0280474137722232 no 168 0.0221420891535165 213 2855798 SGTC_1199 1638-0010 4.46 µM 2.00390178442342 0.0285128592079072 no 169 0.0225402911877795 246 3111136 SGTC_2937 9044753 11.33 µM 2.00014916536334 0.0287484871277893 no 170 0.0227420795672684 267 6465530 YGL099W LSG1 SGTC_2174 5790901 200 µM 1.99838455899199 0.0288598456191951 no 171 0.0228374921808898 242 786020 SGTC_2629 bisabolol 100 µM 1.99704790516491 0.0289444359104751 no 172 0.0229099896203472 246 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1699 st031318 29.054 µM 1.98947196840258 0.0294277825482211 no 173 0.0233245664351864 206 5340658 SGTC_2907 7721985 69.9 µM 1.9879988693734 0.0295225405877423 no 174 0.0234059075084033 238 3267881 SGTC_2447 5741742 33.78 µM 1.98438344201771 0.0297561793238726 no 175 0.0236065552341451 237 1776504 SGTC_1985 st071382 65.5 µM 1.97141888314636 0.0306066320173882 no 176 0.0243379914565099 209 6123237 SGTC_2648 atorvastatin 78.68 µM 1.97016341314312 0.0306900472304565 no 177 0.024409822595121 188 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1867 st057372 64 µM 1.96636435970446 0.0309436091284652 no 178 0.0246282686403507 207 688837 SGTC_278 4092-0821 23.9 µM 1.96279367678795 0.0311835069603024 no 179 0.0248350764230909 233 877900 SGTC_1408 3909-7976 48.8 µM 1.96235917967754 0.0312128035441421 no 180 0.02486034085783 258 24152374 SGTC_1250 0485-0349 40.2 µM 1.95342873258003 0.0318200116189494 no 181 0.0253844071823696 248 6842794 YDL195W SEC31 SGTC_64 000l-0018 272.079 µM 1.95293059796949 0.0318541666446039 no 182 0.0254139097245807 422 6811119 SGTC_2305 7443522 69.23 µM 1.95287954237588 0.0318576690253902 no 183 0.025416935167409 227 5415886 SGTC_2323 6148992 148.28 µM 1.95099849602854 0.0319869295078803 no 184 0.0255286123467944 203 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_3168 9103419 49.47 µM 1.9471111351117 0.0322554311326711 no 185 0.025760706163167 114 16649256 SGTC_3294 9122953 26.2835 µM 1.94211850012446 0.0326030004629971 no 186 0.0260613781916006 230 16459826 SGTC_2368 9071271 200 µM 1.94098219286565 0.0326825361028813 no 187 0.0261302186602298 258 27209959 SGTC_628 1636-0253 16 µM 1.93157906354969 0.0333468652750935 no 188 0.0267057410188955 275 4456143 SGTC_2884 9058502 51.95 µM 1.92754117162406 0.0336355346745102 no 189 0.0269561111199376 256 6471554 SGTC_1296 1068-0102 11.9 µM 1.92431291053579 0.0338678000864888 no 190 0.0271576866334214 229 767053 SGTC_3178 9107506 49.47 µM 1.91922968080768 0.0342361989922086 no 191 0.027477636405672 227 8897194 SGTC_821 1114-0266 29.2 µM 1.91655997280092 0.0344309972264901 no 192 0.0276469286306378 232 3123235 SGTC_1356 1502-0781 85.8 µM 1.91097778973617 0.034841250881411 no 193 0.0280037175937876 242 567702 SGTC_1614 st002383 48.6 µM 1.90548559426265 0.0352487992285445 no 194 0.0283584891398262 232 1947235 SGTC_2065 5221596 34.26 µM 1.8924469765645 0.0362320062796832 no 195 0.0292157260103145 244 788581 SGTC_2137 5261020 140 µM 1.89013885186863 0.0364083731962797 no 196 0.0293696960827948 263 763655 SGTC_2036 5160441 105 µM 1.88924303762611 0.0364770125571987 no 197 0.0294296351615479 334 134534 YIL048W NEO1 SGTC_2111 5486399 200 µM 1.88891729205352 0.0365019981750774 no 198 0.0294514560166391 300 689674 SGTC_262 fenpropimorph 62.5 µM 1.88463736305901 0.0368315835818299 no 199 0.0297394071463162 239 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1898 st060199 18.6 µM 1.88390335890361 0.0368883509062523 no 200 0.0297890244093057 226 688866 SGTC_232 clozapine 119 µM 1.87809552036459 0.0373400514512894 no 201 0.0301840495240342 287 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3200 9114385 49.47 µM 1.8759233831595 0.0375101445704264 no 202 0.0303329006379354 261 17018030 YLR208W SEC13 SGTC_2316 5844804 197.44 µM 1.87433004736013 0.0376353154619715 no 203 0.0304424742651927 354 776813 SGTC_2751 anetholtrithion 17.25 µM 1.8715297482899 0.037856130401658 no 204 0.0306358452580185 256 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2845 9003024 42.97 µM 1.86615439289275 0.0382829613161338 no 205 0.0310098838938666 300 2990173 SGTC_405 ebelactone b 50 µM 1.86554716902908 0.0383314237270519 no 206 0.0310523734990879 261 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_918 glabranin 770.725 nM 1.85244981141955 0.0393889509978192 no 207 0.0319806290809161 286 124049 Also referred to as licorice root. SGTC_1645 Cervolide 78 µM 1.84834269542591 0.0397254215797514 no 208 0.0322763914662241 215 23173 A fragrance. SGTC_646 4092-0839 27.3 µM 1.84716538146678 0.0398223014133514 no 209 0.0323615875041751 259 877796 SGTC_1400 3771-8998 51.5 µM 1.84694246016873 0.0398406669632458 no 210 0.032377740025622 204 670767 SGTC_2464 5717415 7.67 µM 1.84691635250463 0.0398428183144106 no 211 0.0323796321803846 272 5285744 SGTC_1403 3909-7815 62.9 µM 1.84417908329352 0.0400689021578692 no 212 0.0325785228137464 209 6615483 SGTC_459 nigericin 15.3 µM 1.84201630316567 0.040248272500499 no 213 0.0327363825904703 323 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3063 1327-0034 4 µM 1.83576474281873 0.0407704158835626 no 214 0.033196228996686 266 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2134 5324836 1.464 µM 1.83565703106682 0.0407794601324793 no 215 0.0332041983466811 210 699272 SGTC_151 3013-0144 2.285 µM 1.82803377089423 0.0414237098052012 no 216 0.033772241724732 272 906558 YHR107C CDC12 SGTC_2902 5787006 60.46 µM 1.81757604362489 0.0423208960092116 no 217 0.0345644779576855 285 591003 SGTC_1914 st062367 72.6 µM 1.81329339509215 0.0426928199687836 no 218 0.0348932907355006 260 978205 SGTC_2170 morpholine 200 µM 1.81241320561257 0.042769585866771 no 219 0.0349611869443239 232 121171 Reacts with secondary amines. SGTC_1434 4073-0095 163 µM 1.80961532274493 0.0430143450419476 no 220 0.0351777310329507 261 24133745 SGTC_200 k038-0079 37.545 µM 1.80429502665973 0.0434828866086351 no 221 0.0355925345156595 274 3436683 SGTC_2019 4016004 108 µM 1.80206575921253 0.043680431938819 no 222 0.0357675300542342 254 45595336 SGTC_2644 guaiazulene 100 µM 1.79765179078893 0.0440737096131984 no 223 0.0361161027877533 236 3515 A coloring agent. SGTC_2764 methyldopa 94.69 µM 1.7971011870801 0.0441229671984818 no 224 0.0361597786545422 302 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2062 5245942 200 µM 1.7930488700271 0.0444868585207521 no 225 0.0364825550846195 308 1376160 SGTC_583 1488-1091 88.9 µM 1.79160027365295 0.0446175252350541 no 226 0.036598509636892 354 4303273 SGTC_806 3966-4455 5.86 µM 1.78708602935173 0.0450267041689935 no 227 0.0369617925683157 256 714982 SGTC_1301 naphtanilide LB 4.81 µM 1.78424070039379 0.0452861577834206 no 228 0.0371922806939252 278 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1325 1431-0015 227 µM 1.78250251394447 0.0454452465874757 no 229 0.0373336608175015 265 1103340 SGTC_1937 st074714 47.2 µM 1.78223739041465 0.0454695516732683 no 230 0.0373552639001036 303 17250970 SGTC_551 k048-0028 34.9 µM 1.77942291636274 0.0457282123830374 no 231 0.0375852260779557 317 6836383 SGTC_82 0054-0107 293.755 µM 1.77760570449313 0.0458958483918592 no 232 0.037734318121019 247 3104697 SGTC_2383 9036125 200 µM 1.77507796829505 0.0461298503477617 no 233 0.0379425071121883 234 79580 SGTC_706 4262-0057 46.9 µM 1.77334523592194 0.0462908087021762 no 234 0.0380857588058894 312 883298 SGTC_121 0557-0495 61.343 µM 1.77076511696354 0.0465313185142381 no 235 0.0382998844727535 458 3104427 SGTC_86 0417-1630 471.922 µM 1.76467067219454 0.0471034047124801 no 236 0.038809565156521 469 3634867 SGTC_1442 4112-3290 3 µM 1.76100832556504 0.0474498932254699 no 237 0.0391184969352775 316 704353 SGTC_245 methotrexate 289.6 µM 1.75143241911371 0.0483655092309816 no 238 0.0399357263937642 338 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_479 n-linoleoylglycine 10 µM 1.75014898784169 0.0484892934274704 no 239 0.0400463042679394 253 6433346 An anti-infammatory. SGTC_2824 7998404 51.95 µM 1.74927993506326 0.0485732554613071 no 240 0.0401213212894646 284 837851 SGTC_1276 0871-0068 94.2 µM 1.74549784374016 0.0489400102498415 no 241 0.0404491237330936 275 3414906 SGTC_906 1165-0455 526 µM 1.74260557395546 0.0492219680268965 no 242 0.0407012678615532 264 3252859 SGTC_3340 9146634 11.102 µM 1.7377920750159 0.0496940945490615 no 243 0.0411237287959095 283 4907387 SGTC_501 nsc-95397 161 µM 1.73690610756617 0.0497813860989338 no 244 0.0412018726031511 261 262093 SGTC_2943 9068529 45.32 µM 1.73333357498773 0.0501346181062384 no 245 0.0415181982254118 342 3270634 SGTC_1343 1487-0095 224 µM 1.73059813875092 0.0504064311309869 no 246 0.0417617319492744 279 4560101 YGL055W OLE1 SGTC_2911 7942208 15.64 µM 1.72509159873305 0.0509571618774581 no 247 0.0422554831702043 277 1243384 SGTC_226 1,3-diallylurea 8.28947 mM 1.72330868144423 0.0511365014170326 no 248 0.0424163593331192 268 74537 YKL182W FAS1 SGTC_1003 4049-0218 100 µM 1.72229728707686 0.0512384582982792 no 249 0.0425078394556769 341 295161 SGTC_719 2810-4230 27.3 µM 1.72167430596492 0.0513013403746017 no 250 0.042564267154808 240 721079 SGTC_1120 ficusin 1.78878 µM 1.71938219275484 0.0515332288784808 no 251 0.0427724012660822 299 6199 A DNA cross-linker. SGTC_2593 nobiletin 86.24 µM 1.71761649240556 0.0517124289560669 no 252 0.0429332950490957 275 72344 An anti-infammatory. SGTC_617 3770-0098 35 µM 1.71722165549653 0.0517525684536664 no 253 0.0429693401202818 311 5962639 SGTC_848 0368-0089 85.6 µM 1.71551678743837 0.0519261713758359 no 254 0.0431252601197426 313 762535 SGTC_2754 granisetron 64.02 µM 1.70694167066279 0.0528063842546262 no 255 0.0439164472608025 340 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_762 1165-0429 115 µM 1.70051227237759 0.0534740771995502 no 256 0.0445173049886263 323 5967793 SGTC_2481 5478948 45.16 µM 1.69860573463321 0.0536733518676672 no 257 0.0446967476149727 334 77792 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.6930407087889 0.0542583836574733 no 258 0.045223859375552 344 688761 SGTC_577 r071-0003 38.6 µM 1.68606495277097 0.0549988338052417 no 259 0.0458916447549164 470 4568517 YMR134W ERG29 SGTC_1157 4092-0394 27.6 µM 1.68088003228691 0.0555543488398208 no 260 0.0463931095919967 385 3659885 SGTC_2791 5663188 71.43 µM 1.67683221158363 0.0559911054947862 no 261 0.046787648470419 324 54690634 SGTC_177 1327-0068 8.361 µM 1.67321532861398 0.0563836514185708 no 262 0.0471424569009922 383 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_383 2324-0395 7.37 µM 1.67146612567136 0.0565742717483028 no 263 0.0473148220944636 357 3146421 SGTC_1467 k284-1082 293 µM 1.65702163374635 0.0581678384375596 no 264 0.0487575506719422 338 3334705 SGTC_691 1548-0686 185 µM 1.65700790958598 0.0581693691326129 no 265 0.048758937987047 383 46495133 SGTC_672 1441-0018 53.7 µM 1.65693798590376 0.0581771684132599 no 266 0.0487660067548944 315 251141 SGTC_1136 pergolide 1.05886 µM 1.65624714722982 0.0582542686551199 no 267 0.0488358894718396 459 47811 A dopamine receptor agonist. SGTC_2664 lyso-paf C-16 73.48 µM 1.65513702938298 0.0583783301545792 no 268 0.0489483525380691 360 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_978 1416-0512 87.4 µM 1.64449131359354 0.0595786061562869 no 269 0.0500373785561842 396 6814003 SGTC_3229 9132204 49.47 µM 1.63999412353882 0.0600914269540834 no 270 0.0505031944003886 257 17682924 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.63458365971322 0.0607129625189218 no 271 0.0510681776943429 344 688798 SGTC_2429 5902844 64.44 µM 1.62936737592148 0.0613169408900022 no 272 0.0516176354083248 385 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_442 cape 100 µM 1.62858619678755 0.0614077941064445 no 273 0.0517003241379041 310 5281787 SGTC_870 0573-2213 57.6 µM 1.62678254084847 0.0616179657774832 no 274 0.0518916454830047 314 3916321 SGTC_651 3253-0966 34.4 µM 1.62392578683203 0.0619519989322493 no 275 0.05219582414907 386 781462 SGTC_477 mead ethanolamide 10 µM 1.61929391027677 0.0624965937964632 no 276 0.0526920201647543 190 16061185 SGTC_3267 9137951 49.47 µM 1.619124652306 0.0625165648354752 no 277 0.052710222795421 263 16643986 SGTC_2128 5255449 168.493 µM 1.61752534410915 0.0627055156527838 no 278 0.0528824647458995 389 736008 SGTC_3252 9135871 49.47 µM 1.61417298583055 0.0631030251755643 no 279 0.0532449548953868 351 17682838 SGTC_1581 himbacine 57.9 µM 1.61349288067813 0.0631839083277906 no 280 0.0533187343685592 398 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3323 9138564 53.9225 µM 1.61285932987458 0.0632593274990166 no 281 0.0533875363890325 410 43912313 YNL103W MET4 SGTC_122 0236-0016 402.397 µM 1.61238357331381 0.063316008589131 no 282 0.0534392485929007 437 6808838 SGTC_1518 st038567 90.8 µM 1.60691190718056 0.0639707422589708 no 283 0.0540368470018425 316 77966 SGTC_1394 3474-0001 65.7 µM 1.6064548265696 0.0640256734219121 no 284 0.0540870063813908 311 5017666 YIL048W NEO1 SGTC_66 0109-0187 42.4 µM 1.60598374996375 0.0640823249692979 no 285 0.0541387402158802 376 759417 SGTC_1489 4065-0444 182 µM 1.60460373633919 0.0642485093591306 no 286 0.0542905193261525 340 2877968 SGTC_550 4123-0385 25.7 µM 1.60361774048256 0.0643674502449889 no 287 0.05439916892911 353 5731123 SGTC_2742 clothiapine 36.27 µM 1.60259733309475 0.0644907222914586 no 288 0.0545117914691897 293 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2054 5233173 129 µM 1.58238538634628 0.0669704397024257 no 289 0.0567808093795788 440 6889 SGTC_1328 1441-0025 69.2 µM 1.57957778671711 0.0673206490088574 no 290 0.0571017948130786 330 4562601 SGTC_1112 tnp00069 1.16933 µM 1.57579938766377 0.0677941846446994 no 291 0.0575360217881993 433 145826 SGTC_1401 3807-4679 7.6 µM 1.57425769377034 0.0679881380171816 no 292 0.0577139430642583 342 3291456 SGTC_2586 curcumin 80 µM 1.57425591049667 0.067988362610397 no 293 0.0577141491155893 466 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1108 betulinic acid 729.144 nM 1.57041617474194 0.0684732854741946 no 294 0.0581591609540506 377 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_735 3076-0345 636 µM 1.56772128071466 0.0688152159334263 no 295 0.0584730965114465 443 2888990 SGTC_1333 1482-0047 286 µM 1.56336591827931 0.0693706091275603 no 296 0.0589832758669006 413 3811116 SGTC_952 1185-0122 232 µM 1.56324209886771 0.0693864488286728 no 297 0.0589978307406347 407 678600 SGTC_3055 9094636 49.47 µM 1.56064099556614 0.0697198414391628 no 298 0.0593042401524915 343 25236176 SGTC_2399 5884133 200 µM 1.55981829980393 0.0698255455514328 no 299 0.0594014128413898 430 722445 SGTC_1177 0983-0204 23.6 µM 1.55777389430812 0.0700887551768108 no 300 0.0596434282496966 403 766818 SGTC_2265 7929201 200 µM 1.55545287928397 0.0703885016648786 no 301 0.0599191243153757 407 1265108 SGTC_408 cantharidin 100 µM 1.55400809406884 0.0705755849540385 no 302 0.060091242970854 428 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1520 flindersine 88 µM 1.55373986580775 0.070610359495407 no 303 0.0601232398264957 410 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2384 9036245 200 µM 1.55032233936491 0.0710545794246728 no 304 0.0605320840397239 407 6462766 SGTC_1041 0206-0046 107 µM 1.54955309276208 0.0711548636009624 no 305 0.060624409471508 396 50494 SGTC_1701 st028638 40.4 µM 1.54795022526196 0.0713641733336716 no 306 0.0608171404374564 385 3490878 SGTC_1280 0880-0253 10.1 µM 1.5433491983456 0.071967621857979 no 307 0.0613730362985155 425 6836607 SGTC_3299 9121982 43.1275 µM 1.54094269170566 0.0722848021232645 no 308 0.0616653671428422 410 17594604 YPL160W CDC60 SGTC_2115 tiliquinol 12.7705 µM 1.53981765796423 0.0724334497979549 no 309 0.0618024032304375 360 71208 A bioactive hydroxyquinoline. SGTC_516 3992-2719 87.3 µM 1.53974591491666 0.0724429369508284 no 310 0.0618111500350298 349 5350887 YDR037W KRS1 SGTC_260 nsc-65238 3.989 µM 1.53850557518519 0.0726071074624032 no 311 0.0619625232066124 362 3246252 SGTC_717 1532-0246 73.2 µM 1.53744040776511 0.0727483195815861 no 312 0.0620927488074968 416 9561992 SGTC_3219 9131112 49.47 µM 1.52669140079014 0.0741851358275836 no 313 0.0634188833624397 392 17612988 YMR079W SEC14 SGTC_3058 9093861 49.47 µM 1.52584493689068 0.0742991965526414 no 314 0.06352424322982 412 17217477 SGTC_1884 5633444 25 µM 1.51725890507235 0.0754637413239692 no 315 0.0646006646697927 459 5724239 SGTC_198 3454-2873 16.191 µM 1.51479697369722 0.0758002120719553 no 316 0.064911913556496 406 710957 SGTC_887 0885-0007 9.62 µM 1.51408590666258 0.0758976055515943 no 317 0.0650020263154797 447 5719458 SGTC_605 1315-0399 119 µM 1.51193135691398 0.0761932919133149 no 318 0.065275662985211 448 24020461 SGTC_634 1611-4317 11.2 µM 1.51107503095869 0.0763110556664074 no 319 0.0653846677555626 451 2843522 SGTC_1705 st027868 56.3335 µM 1.51032734886594 0.0764139917038204 no 320 0.0654799582757177 363 292948 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.50887968409903 0.0766135970729542 no 321 0.0656647662338113 404 641818 YHR062C RPP1 SGTC_2508 celastrol 40.54 µM 1.5077399336716 0.0767710257390316 no 322 0.0658105503527634 358 122724 Celastrol is a natural product and antioxidant. SGTC_89 0302-0250 142.109 µM 1.50664159791934 0.0769229665865168 no 323 0.0659512744039626 450 4203518 YLR208W SEC13 SGTC_751 0833-0568 350 µM 1.50401772145082 0.0772868718987115 no 324 0.0662884019080532 407 6954252 SGTC_329 k048-0121 21.3 µM 1.50392833538948 0.0772992918432083 no 325 0.0662999100961307 392 6832902 SGTC_3002 9075603 71.4286 µM 1.50374182218198 0.0773252122167964 no 326 0.0663239280961676 430 20105405 SGTC_15 0266-0086 27.098 µM 1.49907327965144 0.0779761684143034 no 327 0.066927311305042 529 1712902 YIL048W NEO1 SGTC_760 0568-0725 82.9 µM 1.49640261509158 0.0783504163909752 no 328 0.0672743842507432 412 3916171 SGTC_1443 4112-3303 14 µM 1.49082562104206 0.0791363263439746 no 329 0.0680036416131319 431 704433 SGTC_1315 1237-0019 3.69 µM 1.48478171141924 0.0799947583848483 no 330 0.0688008290341977 438 825140 SGTC_1372 2752-0194 270 µM 1.4828779374424 0.0802666092883275 no 331 0.0690534220784694 412 823334 SGTC_1327 1436-0082 2.18 µM 1.4770551320833 0.0811024149581437 no 332 0.0698304296705888 417 15992205 SGTC_2894 9048625 32.47 µM 1.47606964212925 0.0812445197337732 no 333 0.0699625987762054 413 4092861 SGTC_139 0099-0334 718.624 µM 1.4748964009217 0.0814139425437407 no 334 0.0701201990510641 522 97690 SGTC_1764 st044502 93.5 µM 1.47230270087652 0.0817894333448142 no 335 0.0704695771455477 449 8407 SGTC_1285 0929-0069 65.5 µM 1.47063097533961 0.0820321404779205 no 336 0.0706954711544845 438 1206237 SGTC_1201 1889-3372 45.9 µM 1.46887873808917 0.0822871186440232 no 337 0.0709328412778813 400 5392199 SGTC_562 3772-2733 112 µM 1.46754381258405 0.0824817715887816 no 338 0.0711140899823524 512 2876874 YIL048W NEO1 SGTC_888 0916-0002 6.97 µM 1.46470391298463 0.0828970260718255 no 339 0.0715008584506199 432 2802138 YIL048W NEO1 SGTC_3009 9080819 71.4286 µM 1.46121511690948 0.0834093136631258 no 340 0.0719782078734989 419 17027216 SGTC_2025 5147754 141 µM 1.46102125389209 0.0834378497377335 no 341 0.0720048043862188 407 315777 YLR208W SEC13 SGTC_2105 5350118 200 µM 1.45893356322985 0.083745616880005 no 342 0.072291697133565 432 2133313 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.45831774273792 0.0838365637476813 no 343 0.0723764909481312 453 94937 An inhibitor of serotonin biosynthesis. SGTC_784 4579-0127 173 µM 1.45449872895339 0.0844022283273891 no 344 0.0729040428064178 470 1948547 SGTC_1849 st056239 19.2 µM 1.45436107333289 0.0844226709406182 no 345 0.0729231131295044 466 5393181 SGTC_167 3672-0051 66.205 µM 1.45345318036203 0.0845575910767374 no 346 0.0730489850689424 425 3237971 SGTC_904 1141-0088 396 µM 1.45283411473925 0.0846496818691319 no 347 0.0731349087554049 442 1378119 SGTC_3348 9149464 3.537 µM 1.44958682608223 0.0851339736276735 no 348 0.0735868859417118 442 1951442 SGTC_1511 0906-3109 28.5 µM 1.44625386745936 0.0856331981124059 no 349 0.0740530049447542 566 2882180 SGTC_2868 9035608 32.47 µM 1.44314270606031 0.0861011758138772 no 350 0.0744901376013508 480 6462614 SGTC_44 0929-0055 61.211 µM 1.43977385155836 0.0866100701617049 no 351 0.0749656956942971 418 1379590 SGTC_1232 0279-0259 161 µM 1.43851058504895 0.0868014758707628 no 352 0.0751446181473578 464 1560000 SGTC_1072 oxiconazole 14.9 nM 1.43180726168477 0.0878224311440505 no 353 0.0760994942437287 500 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_764 1951-2361 146 µM 1.43156909306903 0.0878588696883428 no 354 0.0761335900653261 487 5438930 SGTC_1481 3346-2004 36 µM 1.42762272582819 0.0884642855019263 no 355 0.0767002394032621 466 2770522 SGTC_3251 9135047 49.47 µM 1.42570035196445 0.0887603220433726 no 356 0.0769774274490792 385 17682963 SGTC_2256 7954252 200 µM 1.42507776324027 0.0888563557553605 no 357 0.0770673618609506 366 2972920 SGTC_1251 0490-5699 265 µM 1.42402350905983 0.0890191498267883 no 358 0.0772198334252304 527 3883818 SGTC_2259 7964009 200 µM 1.42354313589753 0.0890934008737421 no 359 0.0772893833770292 420 313134 SGTC_1316 1272-0050 65.9 µM 1.42344175785548 0.0891090767171055 no 360 0.0773040672911033 455 7340392 SGTC_2685 mycophenolic acid 18.85 µM 1.42127106651777 0.0894452182013298 no 361 0.0776189857581714 404 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1633 st005664 67.9 µM 1.41041810768412 0.0911400040775726 no 362 0.0792081308541385 493 2063822 SGTC_1181 1222-0449 220 µM 1.40997879517056 0.0912091047181702 no 363 0.0792729721494908 471 658318 SGTC_290 2043-6722 48.1 µM 1.40768119088202 0.0915711340355803 no 364 0.0796127469185557 471 773758 YLR208W SEC13 SGTC_1620 st003704 16.5 µM 1.40650246852056 0.0917572759396712 no 365 0.0797874860529638 458 2834414 SGTC_1022 4477-0945 21.3 µM 1.40242157870117 0.0924038885490727 no 366 0.0803946966573599 489 4648966 SGTC_1798 st045719 60.953 µM 1.40221072465373 0.0924373895235498 no 367 0.080426165009593 416 3980186 SGTC_3119 9125183 49.47 µM 1.40102293556568 0.0926262760976092 no 368 0.0806036073304378 345 22695334 SGTC_2706 st078239 82.5 µM 1.40058274686079 0.0926963489774854 no 369 0.0806694416110295 464 15434492 SGTC_1546 5-methoxyflavanone 78.7 µM 1.39916608070834 0.0929221317435866 no 370 0.080881592756322 497 147795 SGTC_2162 5663267 200 µM 1.3931833340946 0.0938801236923808 no 371 0.0817821790757385 499 6456493 SGTC_506 n9-isopropylolomoucine 153 µM 1.39267456532659 0.093961925764094 no 372 0.0818591116649762 460 6610355 SGTC_1865 st057639 52.2 µM 1.39204238298053 0.0940636440842594 no 373 0.0819547820024293 486 688818 SGTC_1302 1159-0335 255 µM 1.39199792442088 0.0940708005358072 no 374 0.0819615132393858 467 649284 SGTC_2616 abietic acid 100 µM 1.38992211528071 0.0944053889540025 no 375 0.082276264617054 513 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_478 N-arachidonylglycine 10 µM 1.3893070270425 0.0945047000293256 no 376 0.0823697039974064 333 5283389 SGTC_1724 st037281 8.293 µM 1.38928874671939 0.0945076527165832 no 377 0.0823724822228631 517 574124 YDL195W SEC31 SGTC_2569 tetrandrine 100 µM 1.38454029681123 0.095276940559278 no 378 0.0830965390629751 433 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2266 7929956 200 µM 1.38203768371644 0.0956842350244044 no 379 0.0834800653612285 514 2967153 SGTC_325 2810-4341 181 µM 1.37891593444061 0.0961940862655163 no 380 0.0839603373147911 467 774970 SGTC_3333 9141820 12.094 µM 1.37664545414767 0.0965661588132371 no 381 0.0843109452164772 450 1939433 SGTC_2261 9010538 184.68 µM 1.37262271414348 0.0972279751653361 no 382 0.0849348334107717 411 6457250 SGTC_964 1287-0107 19.4 µM 1.37242208213839 0.0972610698239347 no 383 0.0849660398672303 544 51516812 YPR165W RHO1 SGTC_3322 9139058 2.11 µM 1.37181141931134 0.097361850766653 no 384 0.0850610757240567 492 4908926 YPR165W RHO1 SGTC_2187 6125751 200 µM 1.37116878558352 0.097467990745893 no 385 0.0851611731391946 514 874498 SGTC_1150 3909-7983 10.9 µM 1.36574895810639 0.0983665292520594 no 386 0.0860088859874217 535 23965914 SGTC_1132 3456-3614 2.5 µM 1.36449023393054 0.0985760750046999 no 387 0.0862066629009621 606 3125502 SGTC_364 0083-0097 67.7 µM 1.36337159471515 0.0987625742415267 no 388 0.0863827142980769 494 5207356 SGTC_912 3474-0017 2.18 µM 1.35899234377463 0.0994951659839076 no 389 0.0870745074116967 518 3360550 SGTC_2810 7959871 45.46 µM 1.35846643818554 0.0995834095747217 no 390 0.0871578625626026 573 2974535 SGTC_2470 5664817 21.68 µM 1.35071405010651 0.100890852294248 no 391 0.0883935248950456 482 2859561 SGTC_972 1319-0219 195 µM 1.34967548968778 0.101066952102185 no 392 0.088560048882182 524 23903702 SGTC_2867 9039098 71.43 µM 1.34362653299604 0.10209707579407 no 393 0.0895345925440485 528 6463460 SGTC_1222 0366-0074 1.18 µM 1.3430016875847 0.102203919297324 no 394 0.0896357136995856 531 286520 SGTC_3247 9135149 49.47 µM 1.33943851597308 0.102814747355035 no 395 0.0902139788713017 454 8934436 YOR116C RPO31 SGTC_2228 7354201 200 µM 1.33713586781978 0.103210894650816 no 396 0.090589145566658 486 753451 SGTC_386 1509-0011 3.07 µM 1.32861060887112 0.10468722614324 no 397 0.0919882350858284 625 3107280 SGTC_1026 k007-1105 30.6 µM 1.32604010747793 0.105135350241782 no 398 0.0924132063813887 619 7066794 SGTC_3245 9134821 49.47 µM 1.32335046154075 0.10560572970084 no 399 0.0928594288954172 547 17014901 SGTC_2793 7325131 81.82 µM 1.32088122263864 0.106038901320641 no 400 0.0932704858383606 482 4176441 SGTC_2402 5553605 200 µM 1.31811733747786 0.106525282960446 no 401 0.0937321857616972 545 6758546 SGTC_371 0195-0006 7.36 µM 1.31568808408966 0.106954105061469 no 402 0.0941393776376211 451 3928593 SGTC_2346 9031566 143.75 µM 1.30796581790376 0.108325540190001 no 403 0.0954424517198786 516 4771086 SGTC_1097 itavastatin 7.23 µM 1.30369141574999 0.109090071296529 no 404 0.0961694087280844 554 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_869 0564-0080 44.1 µM 1.30106927947738 0.10956098852621 no 405 0.0966173710011971 563 6843321 SGTC_1229 0139-0193 12.2 µM 1.30018737326136 0.109719700241454 no 406 0.0967683786042421 577 3090752 SGTC_114 0364-0001 490.298 µM 1.2996858344665 0.109810032952094 no 407 0.0968543336855164 564 4003655 SGTC_1061 3448-9325 110 µM 1.2991953441392 0.109898427328302 no 408 0.096938449459352 504 723482 SGTC_1195 1502-0147 41.1 µM 1.29688166756399 0.110316078225974 no 409 0.0973359525731435 577 817940 SGTC_903 1134-0042 114 µM 1.29518345188145 0.110623353329794 no 410 0.0976284759928584 532 701009 SGTC_3207 9114163 49.47 µM 1.29064738256952 0.111447115916318 no 411 0.0984129889043275 627 849233 SGTC_3244 9134489 49.47 µM 1.28552277692983 0.112383029011147 no 412 0.0993048313213354 548 16584271 SGTC_656 4090-1979 187 µM 1.28353586268421 0.112747408171521 no 413 0.0996522017995299 596 22330961 SGTC_2964 9083345 53.42 µM 1.28258508160763 0.112922069515535 no 414 0.0998187397536646 517 17741579 SGTC_2083 5306046 65.942 µM 1.28235002527865 0.112965279831085 no 415 0.0998599433333714 571 539837 SGTC_1404 3909-7820 48.3 µM 1.27944676703765 0.113499957991924 no 416 0.100369886997863 545 23741373 SGTC_712 r015-0009 80.6 µM 1.27865311263616 0.113646434825085 no 417 0.100509618845663 501 6813872 YLR060W FRS1 SGTC_2606 farnesol 9.78 µM 1.27824986532281 0.113720909745982 no 418 0.100580669454294 571 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1772 st048439 82.2 µM 1.27755080392819 0.113850100379709 no 419 0.100703928156616 576 2927068 YDL195W SEC31 SGTC_616 4092-0450 108 µM 1.27673486836711 0.114001022281829 no 420 0.100847933435084 586 787165 SGTC_154 3389-1638 511.116 µM 1.27656984705435 0.114031563251379 no 421 0.100877076456456 487 5238686 SGTC_2472 5377652 49.4 µM 1.27542640999064 0.11424334256776 no 422 0.101079177919314 603 1610903 SGTC_731 3966-0296 387 µM 1.27350539899659 0.114599768911745 no 423 0.101419378973188 557 660956 SGTC_1691 st019933 84.6 µM 1.27220651920127 0.114841212413595 no 424 0.10164987597157 538 6176082 SGTC_2512 diallyl trisulfide 49.23 µM 1.27192659469148 0.114893293808762 no 425 0.101699600819429 519 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1376 2910-0861 41.3 µM 1.26675786313397 0.115857983422778 no 426 0.102620941518492 607 1112859 SGTC_1354 1498-1681 81 µM 1.26659907779702 0.115887709830592 no 427 0.102649341187817 607 5754243 SGTC_1878 temozolomide 1 mM 1.26565327812791 0.116064886410013 no 428 0.102818621250738 525 5394 DNA alkylating agent. SGTC_1444 4112-3581 28 µM 1.26551712464699 0.116090407854739 no 429 0.102843006814348 565 2877249 SGTC_2068 5226020 147 µM 1.26331064708729 0.116504558997512 no 430 0.103238780683019 609 1810509 SGTC_1986 st071812 45 µM 1.25939020532998 0.11724300052678 no 431 0.103944712753953 523 11838594 SGTC_1958 st076513 41.9 µM 1.2569162993062 0.117710680037162 no 432 0.104391972887232 580 732122 YGL099W LSG1 SGTC_1450 4112-4260 37.6 µM 1.25590638647116 0.11790197800059 no 433 0.104574956401768 595 1633175 SGTC_141 0443-0274 32.331 µM 1.25380629123139 0.118300482625888 no 434 0.104956210978265 696 1627241 SGTC_2303 7774051 200 µM 1.25339602259056 0.118378444416297 no 435 0.105030809128205 550 2953184 SGTC_338 4055-0136 114 µM 1.25327998717969 0.118400500771548 no 436 0.105051914525433 579 2900563 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.24913789083053 0.119189746132154 no 437 0.105807321973308 672 91467 include heat shock SGTC_3209 9113616 49.47 µM 1.24783461518526 0.119438841843134 no 438 0.106045814659918 625 16649353 SGTC_1431 4049-0260 9.09 µM 1.24766718072593 0.119470870279046 no 439 0.106076482431049 580 3854841 SGTC_2430 5571206 200 µM 1.24321218162415 0.120325290697715 no 440 0.106894827474446 654 1731771 SGTC_843 0310-0051 143 µM 1.24233862667535 0.120493332571141 no 441 0.107055824705368 588 2065037 SGTC_1723 st034307 2.5525 µM 1.24115462147442 0.120721358082276 no 442 0.107274317353585 579 867466 SGTC_1814 st052110 31.539 µM 1.24066448680399 0.120815841114756 no 443 0.107364859314736 554 674163 SGTC_1940 st075990 51.1 µM 1.23923872814146 0.121090979805093 no 444 0.107628551079595 646 1084979 SGTC_3078 9116413 49.47 µM 1.2378843060321 0.121352760153179 no 445 0.107879481162609 537 17177322 SGTC_3158 9100007 49.47 µM 1.23688556370831 0.121546050059265 no 446 0.108064785133314 516 19297233 SGTC_1284 0929-0043 16 µM 1.23635550591988 0.121648721752295 no 447 0.108163223667482 611 1239883 SGTC_2665 lovastatin 100 µM 1.2353693780782 0.121839895923722 no 448 0.108346531980073 580 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2138 5575593 77.673 µM 1.23302676821635 0.122294888372882 no 449 0.108782888692656 547 762213 SGTC_308 4092-1169 104 µM 1.23135977237763 0.122619385429558 no 450 0.10909416774541 633 2268590 YDL196W YDL196W SGTC_3096 9117468 49.47 µM 1.23101833822794 0.122685923389709 no 451 0.109158002836618 464 41316311 SGTC_1465 k213-0056 144 µM 1.2307134285317 0.122745364946218 no 452 0.109215031939375 577 24048857 YMR208W ERG12 SGTC_77 0828-0286 12.516 µM 1.2274548923608 0.123381871866435 no 453 0.109825832873184 605 745345 SGTC_2526 patulin 37.61 µM 1.2248377419396 0.123894765281768 no 454 0.11031818078002 661 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_902 1120-0002 2.07 µM 1.22450818700518 0.123959455110047 no 455 0.110380289884904 620 3280475 SGTC_19 0279-0214 38.434 µM 1.22367997482766 0.124122132962594 no 456 0.11053648839457 704 3566274 YBR002C RER2 SGTC_2344 7990960 76.95 µM 1.22158639860976 0.12453402006958 no 457 0.110932037363289 562 140813 SGTC_1765 st044815 90.4 µM 1.21973598314686 0.124898862799202 no 458 0.111282488095624 591 645695 SGTC_1357 1503-1303 39.5 µM 1.21946611047075 0.124952135390952 no 459 0.111333665514102 659 292895 SGTC_2553 4-methylesculetin 85.09 µM 1.21920986077651 0.12500273350968 no 460 0.111382275123898 611 5319502 SGTC_1547 harmine 94.2 µM 1.21834601885005 0.125173409987957 no 461 0.111546254628025 676 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1488 4013-0813 75.9 µM 1.21767518432498 0.125306064585875 no 462 0.111673715452733 546 2910057 SGTC_657 3534-0529 86.7 µM 1.21682685367008 0.125473958760018 no 463 0.111835050290442 589 1049549 SGTC_1319 1306-0155 43.7 µM 1.21613623244756 0.125610756350289 no 464 0.111966515114616 668 3122360 SGTC_433 pimozide 108 µM 1.21609877195751 0.125618179462543 no 465 0.111973649152206 488 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1522 st012842 45.6 µM 1.21240256783156 0.126352119023064 no 466 0.112679159227527 561 3491067 YOR116C RPO31 SGTC_32 0928-0142 34.1 µM 1.21097068277391 0.126637243767844 no 467 0.112953320452354 572 2244242 SGTC_816 0325-0417 81.3 µM 1.20519856998753 0.127791160864066 no 468 0.114063327154603 588 68101 SGTC_2657 nystatin 74.44 µM 1.2036414572427 0.128103694705253 no 469 0.114364094283904 642 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3131 9127911 49.47 µM 1.20351776522042 0.12812854412979 no 470 0.114388010442243 600 45595681 SGTC_474 dl-dihydrosphingosine 5 µM 1.20188954778187 0.1284559611486 no 471 0.114703162288045 623 3058739 A sphingolipid protein kinase C inhibitor. SGTC_233 rapamycin 362 pM 1.20118853983445 0.128597105006585 no 472 0.114839036923598 624 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2320 7373003 200 µM 1.20053076851555 0.128729641260933 no 473 0.114966635198534 587 5415828 SGTC_2782 7736369 71.43 µM 1.20052906515683 0.128729984598612 no 474 0.114966965756729 659 2950836 YOL077C BRX1 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.19673073145762 0.129497176906693 no 475 0.115705762368432 659 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1782 st039423 80.636 µM 1.19362176880882 0.130127482307648 no 476 0.116312977351225 584 2068169 SGTC_1671 st016596 74.5 µM 1.19294238876112 0.13026550076541 no 477 0.11644596830417 671 2829167 SGTC_2642 cholecalciferol 100 µM 1.19198185360455 0.130460809648002 no 478 0.116634180327626 600 9821465 A vitamin D precursor, similar to steriods. SGTC_575 k072-0246 11.9 µM 1.19164767190902 0.13052880741283 no 479 0.116699712099907 633 6796779 SGTC_1808 st050063 61.5 µM 1.18909234871016 0.131049563108667 no 480 0.117201664447854 609 4011993 SGTC_1363 1636-0063 10.4 µM 1.18900061940458 0.131068283502598 no 481 0.11721971159475 661 6072185 SGTC_511 blebbistatin 171 µM 1.18624639511093 0.131631234559286 no 482 0.117762504532918 617 3476986 A myosin inhibitor. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.18291766278383 0.132313836709412 no 483 0.118420890403734 718 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_641 4092-0595 30 µM 1.18206802697348 0.132488456326554 no 484 0.118589354831099 661 786260 SGTC_1802 st050112 57.9 µM 1.17963499585345 0.132989378109043 no 485 0.119072708950549 644 4662563 SGTC_1437 4092-1038 11.6 µM 1.17586606135294 0.133767912149799 no 486 0.11982420139616 683 3977136 SGTC_1670 st016595 4.04 µM 1.1749710865367 0.1339532429823 no 487 0.120003141770685 640 597879 SGTC_950 1165-0508 94.1 µM 1.17227930360144 0.134511718828513 no 488 0.120542469050998 603 6148369 SGTC_2189 6047310 154.431 µM 1.17165988439732 0.13464045831144 no 489 0.12066681746049 609 711535 SGTC_1441 4106-0040 13 µM 1.16901264752237 0.135191610261467 no 490 0.121199267874136 620 2904180 SGTC_3285 9112818 20.8695 µM 1.16890575548247 0.135213897516652 no 491 0.12122080219565 692 17017947 YPR165W RHO1 SGTC_614 0462-0418 107 µM 1.16777788552413 0.135449214714304 no 492 0.121448185309624 576 5188303 SGTC_2978 9011784 42.97 µM 1.16656444211903 0.135702699061244 no 493 0.121693155029981 760 2994934 SGTC_1965 Pectolinarigenin 58.4 µM 1.16580355093817 0.135861812388087 no 494 0.121846940606407 653 5320438 An anti-inflammatory. SGTC_2092 5303694 80.6725 µM 1.16516228574065 0.13599600936183 no 495 0.121976654259503 667 1963699 SGTC_2206 7254556 146.969 µM 1.16313332362955 0.136421206026627 no 496 0.122387706839475 600 4398905 SGTC_2038 4100038 30.985 µM 1.16194849484735 0.136669923185975 no 497 0.122628193436908 671 3596803 SGTC_833 3852-0053 558 µM 1.15992849226711 0.137094673063023 no 498 0.123038960583548 734 3123681 SGTC_1886 st057356 49.9 µM 1.15885877870896 0.137319968693549 no 499 0.123256876845856 622 24207747 SGTC_2289 7946404 165.07 µM 1.15561782672836 0.138004098345915 no 500 0.123918756506172 723 1246120 YPR165W RHO1 SGTC_2974 9094440 9.66 µM 1.15347002278923 0.13845875501805 no 501 0.124358757448758 679 25236134 SGTC_1257 0669-0121 16 µM 1.15292829161127 0.138573592096416 no 502 0.124469909291542 720 4307855 SGTC_945 3381-0768 11.3 µM 1.15257478980895 0.13864856297722 no 503 0.124542477867857 706 1126236 YIL048W NEO1 SGTC_2397 5161689 200 µM 1.15252767714618 0.138658556746138 no 504 0.124552151618592 682 2259942 SGTC_2679 rapamycin 1 nM 1.15087448252841 0.139009551235463 no 505 0.124891938513801 752 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_530 4358-1714 28 µM 1.15042955077362 0.139104119183207 no 506 0.124983497401634 724 1564641 SGTC_1217 1183-1422 255 µM 1.14972218718484 0.139254555793077 no 507 0.125129156511083 713 2849664 SGTC_754 3474-0146 171 µM 1.14900540710199 0.139407107917729 no 508 0.125276875534607 618 24762078 SGTC_1706 st031321 9.9705 µM 1.14780085336803 0.139663728759004 no 509 0.125525392482347 677 6103185 SGTC_410 α-linolenic acid 100 µM 1.14625693250841 0.139993118553846 no 510 0.125844428603898 691 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2732 terfenadine 20 µM 1.14548752494663 0.140157465736263 no 511 0.126003630106314 611 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2204 7233102 200 µM 1.14229427773618 0.140840950914977 no 512 0.126665859500706 591 2172480 SGTC_1966 st070145 16.1 µM 1.14090880521448 0.141138200803283 no 513 0.126953937415965 657 3748532 SGTC_400 oxethazaine 37.5 µM 1.14034186339844 0.14125995940754 no 514 0.127071951630035 637 4621 A local anesthetic. SGTC_882 0843-0131 351 µM 1.13943801547355 0.141454220479343 no 515 0.127260253819199 715 5425421 SGTC_1721 st082152 9.2685 µM 1.13916389794089 0.141513171423466 no 516 0.127317400145044 622 5296051 SGTC_220 paclitaxel 373.376 µM 1.1368441479077 0.142012716831962 no 517 0.127801721997145 603 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_370 0180-0345 38.7 µM 1.13674824056126 0.142033395617109 no 518 0.127821773242365 608 3989527 SGTC_315 k915-0449 187 µM 1.13578689857405 0.142240785201869 no 519 0.128022880763253 768 20970215 YNL149C PGA2 SGTC_2095 5432005 200 µM 1.1357195016486 0.142255332372373 no 520 0.128036988074646 629 783734 SGTC_55 0767-0285 6.563 µM 1.13428743603556 0.142564672004973 no 521 0.128336998798415 709 3116166 SGTC_3017 9080681 49.47 µM 1.13289271539639 0.142866381722841 no 522 0.12862965474507 658 16451914 SGTC_3112 9123419 49.47 µM 1.13111999174574 0.143250484492441 no 523 0.129002295465674 709 17015854 SGTC_173 1273-0061 2.693 µM 1.13091666473425 0.143294584672761 no 524 0.129045084241232 696 2847414 YPL266W DIM1 SGTC_2332 7982454 138.89 µM 1.12860620421072 0.143796351121821 no 525 0.129531996151022 693 2981748 SGTC_1943 st076331 65.2 µM 1.12700248515662 0.144145329549256 no 526 0.129870715130932 712 24208415 SGTC_1070 indatraline 8.81 µM 1.12673143276429 0.144204368464167 no 527 0.129928024208207 675 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2871 9038510 12.99 µM 1.12192105693478 0.145254846054633 no 528 0.130948003357387 731 4945164 SGTC_1855 st056195 39.6 µM 1.12158015375244 0.14532948649702 no 529 0.131020496920405 671 4028379 SGTC_3185 9108267 49.47 µM 1.11847524803957 0.146010490410116 no 530 0.131682036074259 682 4910486 SGTC_2965 9082772 38.63 µM 1.1167060400071 0.146399491020723 no 531 0.132060017237477 730 16459634 SGTC_2422 chlorphenesin carbamate 384.24 µM 1.11351232474768 0.147103462150145 no 532 0.132744229026091 723 2724 A muscle relaxant with antifungal properties. SGTC_3283 9109332 35.8195 µM 1.11052988994093 0.147762908133277 no 533 0.133385377704763 602 17027281 SGTC_3273 9137859 49.47 µM 1.10947604026123 0.147996397375143 no 534 0.133612437474657 686 2377234 SGTC_2216 7189485 200 µM 1.10789921591799 0.148346216994708 no 535 0.133952672134752 713 731273 SGTC_1650 st011916 45.8 µM 1.10232690839126 0.149586865262015 no 536 0.135159787549657 702 242528 SGTC_3258 9138477 49.47 µM 1.10013310747351 0.150077198910628 no 537 0.13563706531638 701 4970355 SGTC_602 3130-1533 38.1 µM 1.0999381744398 0.150120819922245 no 538 0.135679530237264 765 720941 SGTC_1153 4055-0057 267 µM 1.09983371038989 0.150144199774402 no 539 0.135702290813252 724 882706 SGTC_2339 9000433 200 µM 1.09832364125745 0.150482435906701 no 540 0.136031596095657 623 2988954 SGTC_1951 sophoraflavanone G 9.2 µM 1.09689287870327 0.15080337632969 no 541 0.13634411106623 741 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3154 9100113 49.47 µM 1.09599197611413 0.151005695250044 no 542 0.136541142959995 696 25237525 SGTC_1558 st069300 45.6 µM 1.09481367732952 0.151270582534814 no 543 0.136799136558137 638 24208000 SGTC_2636 apigenin dimethyl ether 100 µM 1.09173002284806 0.151965265017548 no 544 0.137475892404689 717 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2386 9075165 157.42 µM 1.08969024417205 0.15242594693464 no 545 0.13792480750819 710 16452277 SGTC_2021 4019055 173 µM 1.08868511143058 0.152653295668791 no 546 0.138146384798425 838 44827708 YER133W GLC7 SGTC_1897 st060201 15 µM 1.08813617337548 0.152777553670163 no 547 0.138267498308878 671 611878 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.08612016865434 0.153234473327781 no 548 0.13871291518259 688 279621 SGTC_811 0416-0114 265 µM 1.08460877689377 0.15357761771345 no 549 0.139047483021333 696 6612453 SGTC_3177 9107506 49.47 µM 1.08144326433988 0.154297959223246 no 550 0.139749992661774 688 8897194 SGTC_2811 7967822 32.47 µM 1.08002948251107 0.154620398892006 no 551 0.140064525809035 722 2232244 SGTC_2178 5812956 200 µM 1.07824208951485 0.155028684557233 no 552 0.140462866591747 702 5403383 SGTC_3277 9138724 49.47 µM 1.0760871437468 0.155521874266819 no 553 0.140944142408196 629 15943418 SGTC_1164 k060-0068 93.7 µM 1.0751140668558 0.155744915476828 no 554 0.14116183114848 772 5963676 SGTC_2248 tofa 1.1 µM 1.07312916530123 0.156200533008094 no 555 0.141606583434341 698 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1812 st052057 4.327 µM 1.07278735780377 0.156279080597428 no 556 0.14168326715644 748 3645418 SGTC_2537 larixol 68.93 µM 1.06255611998905 0.158642269919306 no 557 0.143991647612094 795 6708759 SGTC_3057 9095946 49.47 µM 1.06223741032234 0.158716259167789 no 558 0.144063960225751 758 24540043 SGTC_2044 5102272 200 µM 1.06140369244037 0.158909915844604 no 559 0.144253239790919 689 592666 SGTC_1889 st059080 5.18 µM 1.06109301156415 0.15898212064222 no 560 0.144323816747617 797 176925 Isolated from Daphnopsis sellowiana. SGTC_799 1310-0557 151 µM 1.06051234050327 0.159117131014876 no 561 0.14445578940315 742 5354492 SGTC_2979 9012552 45.46 µM 1.05918994576837 0.159424877907574 no 562 0.144756641514022 689 17100905 SGTC_768 0384-0033 77.3 µM 1.05789590386003 0.159726403530923 no 563 0.145051451423669 757 3965305 YMR134W ERG29 SGTC_1023 4482-3888 16 µM 1.05683826315373 0.159973122076471 no 564 0.145292704105204 746 3303168 SGTC_1655 st012546 55.1 µM 1.05462652487268 0.160489865011245 no 565 0.145798083833591 717 720985 YLR208W SEC13 SGTC_1632 st005650 90 µM 1.04950823390395 0.16168986194829 no 566 0.146972133805716 726 2759605 SGTC_1249 0481-0015 10.2 µM 1.04938642632641 0.161718491119664 no 567 0.147000151442131 691 4227577 SGTC_1473 k844-0725 134 µM 1.04769065561937 0.162117401486955 no 568 0.147390577091906 825 54682906 SGTC_638 3970-0837 4.09 µM 1.04580528200489 0.162561665355896 no 569 0.147825470999203 756 4118451 YLR208W SEC13 SGTC_3265 9137266 49.47 µM 1.04493975972281 0.162765879510308 no 570 0.148025406083439 729 17224265 SGTC_2449 5812982 45.77 µM 1.04453785022407 0.162860764052313 no 571 0.148118308421951 710 776185 SGTC_673 1082-0474 110 µM 1.04403005225433 0.162980698624752 no 572 0.148235742912806 839 3098046 SGTC_2465 5809242 33.21 µM 1.04399430884321 0.16298914286658 no 573 0.148244011359754 759 2731748 SGTC_1841 st054148 70 µM 1.04257913401998 0.163323700960613 no 574 0.148571628684707 702 675442 SGTC_1771 st048882 4.1505 µM 1.03993853889751 0.163949149735883 no 575 0.149184228017297 750 4580403 SGTC_2203 7227154 166.4 µM 1.03345136006055 0.165492286147806 no 576 0.15069636085734 746 896304 SGTC_3015 9080845 49.47 µM 1.03329653263526 0.16552923011679 no 577 0.150732574710217 823 5296973 SGTC_1978 st071761 42 µM 1.02810544663724 0.166770982346343 no 578 0.15195011442482 735 5147680 SGTC_92 0063-0024 660.874 µM 1.02773974748178 0.166858686753801 no 579 0.152036132723597 849 3594437 SGTC_2617 dihydrotanshinone i 20.83 µM 1.02463590842653 0.167604267744467 no 580 0.152767507331631 799 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2938 9059746 27.26 µM 1.02352131435868 0.167872530038503 no 581 0.153030713733156 741 6471769 SGTC_3274 9138298 49.47 µM 1.02236020289351 0.168152282008042 no 582 0.153305224520013 817 17015756 SGTC_2475 5812728 15.03 µM 1.02222730877583 0.168184319923201 no 583 0.153336664235203 806 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2194 5927483 104.545 µM 1.02167036624992 0.168318629507769 no 584 0.153468470585687 823 760979 SGTC_2433 5607874 27.82 µM 1.02068156604946 0.168557253730595 no 585 0.153702665463765 759 2252428 SGTC_1573 oleylamine 1.06 µM 1.02053376357271 0.168592941139341 no 586 0.153737692430041 760 5356789 An amine of the fatty acid oleic acid. SGTC_2212 7123476 200 µM 1.02024079622762 0.168663693451701 no 587 0.153807136905505 696 1085715 SGTC_1669 st015249 58.4 µM 1.01957713954552 0.168824038693491 no 588 0.153964525722772 813 722793 SGTC_1358 1509-0022 2.48 µM 1.0169710293359 0.169454644771968 no 589 0.154583605700596 791 3258434 SGTC_2741 miltefosine 3.04 µM 1.01543495673787 0.169827038653738 no 590 0.154949268423131 692 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2502 avocadyne acetate 18.59 µM 1.01475086461085 0.169993053565014 no 591 0.155112300546279 838 3952079 SGTC_1615 st002656 86.5 µM 1.01440886948751 0.170076087648306 no 592 0.155193846914309 784 1584458 SGTC_2438 5259590 200 µM 1.01390599143873 0.170198230212768 no 593 0.155313806093699 827 1201127 SGTC_1274 0865-0114 173 µM 1.01228723755599 0.170591786107823 no 594 0.15570036761028 785 870624 SGTC_2385 9074692 200 µM 1.00838281989835 0.171543434142423 no 595 0.15663535867112 789 17046906 SGTC_3010 9080089 71.4286 µM 1.00652875980809 0.171996521353655 no 596 0.157080642119226 807 17027233 SGTC_293 4049-0273 38.5 µM 1.00577532767603 0.172180859960008 no 597 0.157261829082295 747 1380311 SGTC_34 0469-0683 81.75 µM 1.00499393252625 0.172372173276482 no 598 0.157449885745107 796 3690923 SGTC_3257 9139206 32.98 µM 1.00348310969301 0.172742460821563 no 599 0.157813911153337 771 4910041 SGTC_2980 9014342 25.29 µM 1.00330014111191 0.172787338984153 no 600 0.157858034036479 739 2996599 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.00311417807657 0.17283295923439 no 601 0.157902887332851 824 442882 SGTC_2499 avocadenofuran 51.48 µM 1.0024834782354 0.172987738995221 no 602 0.158055071099824 746 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_581 0958-0271 211 µM 1.00176688405492 0.173163705182258 no 603 0.158228097418045 845 4591145 SGTC_1298 1079-1278 263 µM 1.00143299437969 0.17324573373316 no 604 0.158308759683249 835 2840950 SGTC_2005 4024620 188 µM 0.999736884773289 0.173662808510767 no 605 0.158718928489267 805 236743 SGTC_2887 9044784 58.44 µM 0.998886726956014 0.173872103180087 no 606 0.158924783362927 899 6465546 SGTC_3197 9113331 49.47 µM 0.998176825720903 0.174046991864064 no 607 0.159096810883515 802 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2571 chrysanthemic acid 100 µM 0.997331588155277 0.174255367302466 no 608 0.159301792944625 742 2743 An insecticide. SGTC_2624 nerol 100 µM 0.993856208813467 0.175113813620689 no 609 0.160146438241461 802 637566 A natural product oil. SGTC_1384 3089-0840 101 µM 0.992665878354315 0.175408450403861 no 610 0.160436404324172 772 1069836 SGTC_1919 st067113 52.3 µM 0.991588073834093 0.175675505128261 no 611 0.160699254684237 792 1268243 SGTC_2338 7999974 200 µM 0.990076103854029 0.176050569804785 no 612 0.161068461163892 873 315925 SGTC_2293 7624732 200 µM 0.989767754441779 0.176127122253958 no 613 0.161143824609345 749 894453 SGTC_2482 5981709 142.65 µM 0.982636117168027 0.1779035366335 no 614 0.162893281023761 822 877755 SGTC_1807 st050092 58.9 µM 0.980627952232782 0.1784057808586 no 615 0.163388122445644 785 5008496 SGTC_1242 0402-0103 60.1 µM 0.980395149849892 0.178464062713437 no 616 0.163445551478103 760 432868 SGTC_1371 2421-0008 32.7 µM 0.979045079074102 0.178802288061471 no 617 0.163778853152494 784 2827552 SGTC_792 4534-1957 155 µM 0.978896809310266 0.178839457794752 no 618 0.163815484441101 810 1717904 SGTC_2646 retinol 96.75 µM 0.978624929650059 0.17890762791635 no 619 0.163882668405198 801 445354 A vitamin A analog and teratogen. SGTC_2681 menadione 3.18 µM 0.978155765773545 0.17902530282184 no 620 0.163998645156875 813 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_752 1896-0090 130 µM 0.97742823307701 0.179207877654545 no 621 0.16417859565641 841 772567 SGTC_3045 9092950 49.47 µM 0.976680804574231 0.179395567264049 no 622 0.16436360056388 861 44120432 SGTC_793 0488-0545 106 µM 0.975973256862626 0.179573356085012 no 623 0.164538858585009 814 292548 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.974466129526215 0.179952428017024 no 624 0.164912574315253 749 61125 An anti-inflammatory. SGTC_2510 benzyl isothiocyanate 8.31 µM 0.973452712396215 0.180207604538422 no 625 0.165164175739143 788 2346 DNA damaging agent; causes G2/M arrest. SGTC_857 0438-0306 1.35 µM 0.971379998267733 0.180730216898829 no 626 0.165679542535764 832 4686136 SGTC_420 mitomycin C 81.9 mM 0.969630841513015 0.181171986294322 no 627 0.166115267039169 821 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2760 etidronate 98.04 µM 0.966710375876891 0.181911089006353 no 628 0.166844419340062 787 3305 A chelator and antioxidant. SGTC_2101 5377231 179.231 µM 0.966696568728263 0.181914587750864 no 629 0.166847871465601 838 2844213 SGTC_117 lucigenin 22.078 µM 0.965864884070294 0.182125415040436 no 630 0.16705589799066 864 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_475 α-linolenic acid 10 µM 0.965049971929135 0.182332138677786 no 631 0.167259891412501 887 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1182 1222-0449 220 µM 0.964841884085952 0.18238494905571 no 632 0.167312006862935 810 658318 SGTC_3102 9121669 49.47 µM 0.964528667806136 0.182464457876525 no 633 0.167390471384453 810 41905072 SGTC_178 4092-0806 87.505 µM 0.962155488282457 0.183067584231321 no 634 0.167985752273415 879 2169044 SGTC_1860 st056228 74.6 µM 0.96207771993542 0.1830873695159 no 635 0.168005282469496 811 688679 SGTC_269 exalamide 29 µM 0.96202010994468 0.183102027111088 no 636 0.168019751179868 837 3316 A derivative of salicylamide. SGTC_2614 arthonioic acid 13.39 µM 0.961588736781113 0.183211803786863 no 637 0.168128115741795 795 6710684 SGTC_360 0957-0399 1.01 µM 0.959752749957377 0.183679488252625 no 638 0.168589833925011 866 6752301 YPR165W RHO1 SGTC_1028 k015-0029 4.8 µM 0.958900295953255 0.183896888143422 no 639 0.168804487839079 832 4588309 SGTC_2287 7945887 168.79 µM 0.957524506778275 0.184248091159924 no 640 0.169151291481631 892 1245853 SGTC_138 0850-0259 40.9225 µM 0.957170879545993 0.184338430336734 no 641 0.169240506331647 918 6813004 SGTC_917 harmaline 728.087 nM 0.954902210351926 0.184918649944705 no 642 0.169813575940728 833 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1053 3366-3204 134 µM 0.950853278845779 0.185956993966859 no 643 0.170839430956426 838 3632071 YPR165W RHO1 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.947870729152637 0.186724173142004 no 644 0.17159763394011 805 6708514 SGTC_3184 9108758 49.47 µM 0.94552871936579 0.187327962172624 no 645 0.172194507908043 853 902885 SGTC_1090 efavirenz 20.7 µM 0.944920511097042 0.18748496038918 no 646 0.172349729550854 862 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.943752138412747 0.187786783217722 no 647 0.172648161850432 931 1273210 SGTC_207 4185-0010 4.486 µM 0.943406362583561 0.187876164149235 no 648 0.172736544991347 952 3761753 SGTC_2071 5230951 39.92 µM 0.941085975483449 0.188476649412613 no 649 0.173330400966767 916 1799272 SGTC_2112 5488546 200 µM 0.937664175761254 0.189364322428447 no 650 0.174208509824138 853 600757 SGTC_1379 2144-0755 36.5 µM 0.937382768819436 0.189437438510483 no 651 0.174280850614281 923 5392327 SGTC_1417 3966-0327 90.4 µM 0.937336679903503 0.189449415140569 no 652 0.174292700430116 913 651118 SGTC_847 0342-0274 5.54 µM 0.936934238035511 0.189554013171102 no 653 0.174396193089962 901 18097 SGTC_2017 5132927 60.65 µM 0.934846740017769 0.190097141442106 no 654 0.174933644011827 872 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1837 st055472 66.5 µM 0.934837245721628 0.190099613864601 no 655 0.174936090828599 887 676091 SGTC_2404 5161160 200 µM 0.931477392028286 0.190975798428757 no 656 0.175803336958629 905 2831543 SGTC_2188 6126565 140.678 µM 0.930085662343807 0.191339458851246 no 657 0.176163366814211 843 874518 SGTC_3324 9138759 60.749 µM 0.927899509881145 0.191911559040853 no 658 0.176729849342415 873 45595710 SGTC_710 3448-4187 58 µM 0.926984254297907 0.192151385387385 no 659 0.176967354797455 943 3946412 SGTC_3137 9097352 49.47 µM 0.926271937131411 0.192338162176112 no 660 0.177152337980912 893 44120435 SGTC_2120 5538279 151.968 µM 0.925845972381944 0.192449907486152 no 661 0.177263016023229 879 2058197 SGTC_1487 3970-0795 2.82 µM 0.921019275510032 0.193718888670015 no 662 0.178520181763329 911 3765103 SGTC_956 1185-0240 191 µM 0.919246023029018 0.194186370880955 no 663 0.178983451792203 869 1416193 SGTC_859 0439-0102 54.6 µM 0.918918495922971 0.19427279190516 no 664 0.179069102388303 957 610143 SGTC_1838 st055369 84.5 µM 0.918810935695354 0.194301177763431 no 665 0.1790972357531 882 676036 SGTC_3040 9091894 49.47 µM 0.914677862572508 0.195393835382753 no 666 0.180180384639372 817 25236966 SGTC_2998 9066762 71.4286 µM 0.913782439585257 0.19563104871744 no 667 0.180415587715525 902 4945196 SGTC_1149 3909-7961 23.3 µM 0.913319094024933 0.195753865740714 no 668 0.180537371484878 878 735261 SGTC_2400 5203494 178.7 µM 0.912719037621905 0.195912989652898 no 669 0.180695164353181 825 6777674 SGTC_2589 lobaric acid 100 µM 0.912535625578999 0.195961642806618 no 670 0.180743412256183 873 73157 A novel microtubule depolymerizer. SGTC_3147 9097027 49.47 µM 0.911504953471964 0.196235182365817 no 671 0.181014688419443 938 25236841 SGTC_2775 cyproheptadine 69.59 µM 0.910863362111811 0.19640557705693 no 672 0.18118368606269 925 2913 A selective serotonin reuptake inhibitor. SGTC_259 usnic acid 108.925 µM 0.910536397500661 0.196492447239321 no 673 0.181269847806578 911 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2121 5257820 149.641 µM 0.909673753468468 0.196721752098632 no 674 0.181497294970761 961 791256 SGTC_3132 9126706 49.47 µM 0.907198691570477 0.197380562982539 no 675 0.182150867766818 854 850858 SGTC_3208 9114115 49.47 µM 0.907106675280408 0.19740508153601 no 676 0.18217519421348 797 650895 SGTC_1844 rapamycin 4 nM 0.906320897775159 0.197614533907821 no 677 0.182383013772198 963 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.902952756585383 0.198513847318649 no 678 0.183275484559527 857 6708760 SGTC_853 0419-0306 21 µM 0.902434339791274 0.198652486555201 no 679 0.183413093126606 823 762713 SGTC_693 4161-2696 114 µM 0.902127943286713 0.198734453047366 no 680 0.18349445329867 873 805759 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.901384435761813 0.198933439242967 no 681 0.183691976931401 965 688664 SGTC_491 tetrandrine 80.3 µM 0.900863478925654 0.19907293533205 no 682 0.183830455622884 881 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2306 7482397 179.52 µM 0.900775305132624 0.199096551370311 no 683 0.183853900065212 907 891448 SGTC_1899 st063254 59.6 µM 0.898511337571071 0.19970349926226 no 684 0.184456501787351 809 3093813 SGTC_1785 bathophenanthroline 24 µM 0.896639594146337 0.200206135284287 no 685 0.184955631580367 878 72812 An iron chelator. SGTC_2369 9071472 200 µM 0.896424774409821 0.200263871347096 no 686 0.185012970276979 922 17296037 SGTC_2818 7996756 12.99 µM 0.895710891201183 0.200455810143561 no 687 0.185203596022397 855 2241621 SGTC_3282 9108498 15.4605 µM 0.895586068864034 0.200489381948983 no 688 0.185236939420347 864 16459645 SGTC_981 1488-1094 54.9 µM 0.893146885390319 0.201146094212223 no 689 0.185889258833765 868 3449522 SGTC_2437 5741531 144.16 µM 0.892599743081446 0.2012935807209 no 690 0.186035778405895 957 2262990 SGTC_2085 5307070 144.047 µM 0.892384765720983 0.20135154729333 no 691 0.186093366910602 860 2840351 SGTC_2507 purpurin 79.67 µM 0.891806623445911 0.201507487412691 no 692 0.186248295467718 938 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1183 1254-0324 198 µM 0.890434060238124 0.201877993393801 no 693 0.186616430182577 936 5799357 SGTC_3133 9127736 49.47 µM 0.890313939217851 0.201910437932726 no 694 0.186648669226875 921 27243420 SGTC_3032 9089427 49.47 µM 0.88998074933379 0.202000448444223 no 695 0.186738111450294 895 17173707 SGTC_1360 1598-0022 39.8 µM 0.888927758421978 0.202285069458654 no 696 0.187020953016349 993 761525 SGTC_1145 3546-0597 10.2 µM 0.888121238601035 0.202503232044869 no 697 0.187237769661387 935 875334 SGTC_986 1493-0483 84 µM 0.887070740932071 0.202787601160863 no 698 0.187520407805795 902 40079 SGTC_653 0203-0016 55.2 µM 0.886611074367352 0.202912107638261 no 699 0.187644164740082 935 295302 SGTC_2777 climbazole 1.536 µM 0.88634382674135 0.202984516008234 no 700 0.187716139535766 942 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2804 7954240 19.48 µM 0.885005709702224 0.203347298925559 no 701 0.188076775941061 941 828705 SGTC_3033 9090887 49.47 µM 0.883969855891603 0.203628399390181 no 702 0.188356242724162 949 19325384 SGTC_2855 9016525 58.44 µM 0.883803102808952 0.20367367294951 no 703 0.18840125557322 954 43811474 SGTC_540 1187-0821 17.3 µM 0.883647946607334 0.20371580333863 no 704 0.188443143951771 906 847520 SGTC_202 3594-0513 34.79 µM 0.881808905593239 0.20421556358357 no 705 0.188940077457226 910 708429 SGTC_2528 xanthyletin 44.79 µM 0.881278308454963 0.20435988920313 no 706 0.189083601841635 926 65188 An natural product with antifungal activity of unknown mechanism. SGTC_921 1561-0023 372 µM 0.879409948271043 0.204868577578397 no 707 0.189589520023374 968 24050882 SGTC_1032 k061-1018 98.7 µM 0.875968540550444 0.205807519440692 no 708 0.190523568217263 1006 4005393 SGTC_941 3237-0776 460 µM 0.875712053859152 0.205877600481475 no 709 0.190593295392508 913 760008 SGTC_1678 st019265 80.2 µM 0.875340154051798 0.205979241522213 no 710 0.190694426014571 976 5367020 SGTC_1913 st060213 96.1 µM 0.873811904126599 0.206397227941581 no 711 0.191110348266565 988 688959 SGTC_2869 9037858 32.47 µM 0.870476807243209 0.207311142254102 no 712 0.192019944203635 956 27187042 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.870341750830494 0.207348202011491 no 713 0.192056834475205 957 2333 A French combination drug. SGTC_2801 7907800 81.82 µM 0.868752439874802 0.207784606384597 no 714 0.192491275935049 943 6620925 SGTC_2719 novobiocin 32.65 µM 0.868752194987098 0.207784673669389 no 715 0.192491342921872 909 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2342 7990637 118.86 µM 0.868264733930935 0.207918632875523 no 716 0.192624711744188 966 2033102 YER133W GLC7 SGTC_1331 1472-0049 76.2 µM 0.868142693121022 0.207952178898762 no 717 0.192658110816311 907 24051409 SGTC_3143 9086658 49.47 µM 0.867562711504508 0.208111645283167 no 718 0.192816883531327 982 25236626 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.863718171446002 0.209170527944689 no 719 0.193871364423595 948 7104 SGTC_1307 1187-1599 12.2 µM 0.86363524815741 0.209193401986917 no 720 0.193894147287808 949 1538471 SGTC_100 0086-0128 49.5915 µM 0.863166285834699 0.2093227909925 no 721 0.194023023642259 991 93297 SGTC_1223 0764-0573 147 µM 0.862265390359591 0.209571484581232 no 722 0.19427074669281 1009 1609797 SGTC_2572 astragaloside iv 100 µM 0.861994109182659 0.209646406201896 no 723 0.194345379743627 925 45006101 An anti-inflammatory agent. SGTC_3181 9108277 49.47 µM 0.861747905815778 0.209714415541129 no 724 0.194413128664964 953 17097298 SGTC_3259 9138485 49.47 µM 0.860895010567457 0.209950113102959 no 725 0.194647934952981 1022 17646153 SGTC_744 1594-0068 283 µM 0.856622532326236 0.211133153223311 no 726 0.195826764452478 987 668392 SGTC_789 1309-1135 70.6 µM 0.855889480400238 0.211336525676816 no 727 0.196029457109378 991 3092424 SGTC_309 k408-0051 1.48 µM 0.854970086871588 0.211591757495642 no 728 0.196283854009075 989 3640463 SGTC_2471 5466956 24.79 µM 0.8528854330848 0.212171143923286 no 729 0.196861420273306 947 724419 SGTC_359 0081-0058 15.9 µM 0.852265297065093 0.21234367673649 no 730 0.197033431186991 891 3494159 SGTC_2945 9067681 61.76 µM 0.848688365958022 0.213340441335467 no 731 0.198027360785722 985 16456930 SGTC_171 k064-0041 9.68 µM 0.847208719269704 0.213753562983154 no 732 0.198439397183616 882 53325 SGTC_1945 st075991 56.6 µM 0.844891858202164 0.214401372417053 no 733 0.199085610343434 883 1084980 SGTC_1014 4130-3005 69.3 µM 0.842157485737137 0.215167387665218 no 734 0.199849903694847 974 743608 SGTC_1475 4092-1048 11.7 µM 0.840161783030451 0.215727471256766 no 735 0.200408841471035 999 2881759 SGTC_2411 st077133 39.94 µM 0.839760810717117 0.215840103926486 no 736 0.200521255231672 1025 1403142 YNL221C POP1 SGTC_2618 avocadyne 43.43 µM 0.839448279737964 0.21592791715448 no 737 0.20060890045975 968 3015189 SGTC_714 4296-0578 26.1 µM 0.838716189261066 0.216133696910896 no 738 0.200814295689022 991 1589775 SGTC_1590 st077108 57.8 µM 0.83840568394931 0.216221009629802 no 739 0.200901449129752 993 5489485 SGTC_2957 9076800 11.52 µM 0.837890844398532 0.216365825227707 no 740 0.201046005640274 909 16459615 SGTC_1697 st025554 27.742 µM 0.837666884256207 0.216428838919898 no 741 0.201108908577123 966 1269519 SGTC_3234 9132280 49.47 µM 0.837132752345384 0.216579165772363 no 742 0.201258976058363 978 17612295 SGTC_1610 st001799 48.1 µM 0.836958568411217 0.216628201407081 no 743 0.201307928565277 905 621897 SGTC_3129 9127257 49.47 µM 0.835298862764978 0.217095757792496 no 744 0.201774728780667 869 837894 SGTC_3243 9134147 49.47 µM 0.834447621873135 0.217335787267018 no 745 0.202014395658453 1056 24282180 SGTC_2870 9038528 12.99 µM 0.830935800861644 0.218327655227481 no 746 0.203004948838459 908 6463316 SGTC_327 1273-0057 3.96 µM 0.829768562058808 0.218657903090039 no 747 0.203334824340776 970 3108138 SGTC_2367 9070478 135.38 µM 0.828044865692049 0.219146115420696 no 748 0.203822545853469 974 572802 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.827262514358492 0.219367911859241 no 749 0.20404414277411 1008 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_76 0433-0009 400.328 µM 0.826601303703624 0.219555465477945 no 750 0.204231539097434 895 2841569 SGTC_10 0279-0212 42.575 µM 0.825116760637322 0.219976894211139 no 751 0.204652652503934 1085 39851 YBR002C RER2 SGTC_1016 4226-1401 38 µM 0.824007333426456 0.220292138711221 no 752 0.204967695555318 1034 2901613 SGTC_1064 honokiol 6.76 µM 0.823837840090247 0.220340323156702 no 753 0.205015851801998 997 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2490 carminic acid 95.39 µM 0.823378417527011 0.220470960567504 no 754 0.20514641621519 962 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1317 1273-0028 910 nM 0.823198451340228 0.22052214628658 no 755 0.205197574708476 1011 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_446 go6976 132 µM 0.822199615627329 0.220806357422558 no 756 0.205481648750941 999 3501 A protein kinase C inhibitor. SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.821654930031424 0.220961431917296 no 757 0.205636658495308 1026 165506 SGTC_3092 9117248 49.47 µM 0.821336188233956 0.221052208079994 no 758 0.205727400044893 1076 17141857 SGTC_2982 9019404 25.97 µM 0.81977057444657 0.221498397256182 no 759 0.20617345436123 946 22333232 SGTC_2928 9011484 9.79 µM 0.819328648992655 0.221624436084923 no 760 0.206299465699937 950 2994751 SGTC_1189 1431-2119 7.28 µM 0.818878708258717 0.221752802999421 no 761 0.206427809412259 1040 3107275 SGTC_3166 9102297 49.47 µM 0.817000503691443 0.222289108355028 no 762 0.206964070100091 1010 25237072 SGTC_255 tunicamycin 200.472 nM 0.816575996820352 0.222410425134403 no 763 0.20708538845628 1010 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_157 1348-1695 65.819 µM 0.814623777367606 0.222968821881355 no 764 0.207643847906421 1006 5380510 SGTC_2389 9091542 195.52 µM 0.812448578501099 0.223591937313844 no 765 0.208267140596482 997 3626624 YOL127W RPL25 SGTC_1075 aripiprazole 15.2 µM 0.81156800111579 0.223844472069722 no 766 0.208519779329727 1075 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.810028944883254 0.224286236491935 no 767 0.208961770109935 1089 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2806 7952793 58.44 µM 0.809956285813629 0.224307104483047 no 768 0.208982650191523 1005 2972490 SGTC_820 1582-0060 59.9 µM 0.809033122788997 0.224572336745904 no 769 0.209248047096487 996 3848840 SGTC_1031 k035-0009 16 µM 0.808954932536922 0.224594809613133 no 770 0.209270534848012 1096 5180959 SGTC_2405 ticlatone 3.52 µM 0.808644572721471 0.224684023529766 no 771 0.209359809291955 1029 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_3313 9133968 57.047 µM 0.808129820343977 0.224832035042507 no 772 0.209507926291341 1051 1494643 SGTC_142 0335-0849 62.6745 µM 0.807932333188925 0.22488883502045 no 773 0.209564768428395 1057 3889043 YPR107C YTH1 SGTC_40 0327-0103 19.753 µM 0.807259952232147 0.225082281864324 no 774 0.209758365834251 979 409036 SGTC_2666 tannic acid 100 µM 0.806790344895529 0.225217445782748 no 775 0.209893641350511 1057 16134267 A thiamine antagonist. SGTC_2733 amorolfine 100 µM 0.804217798712069 0.225958699668678 no 776 0.210635600647177 1013 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_678 1218-2179 85.9 µM 0.802261759378931 0.22652323506014 no 777 0.211200778970737 1018 6820081 YOR116C RPO31 SGTC_1741 st038134 10.228 µM 0.801833616944222 0.226646908016136 no 778 0.211324604945262 1097 1272587 SGTC_3268 9137683 49.47 µM 0.801089320922008 0.226861995582476 no 779 0.211539969038005 1020 1953228 SGTC_1989 st071868 50.2 µM 0.799777809968453 0.227241277660624 no 780 0.211919770879097 1070 16414057 SGTC_1552 6-methylflavone 10.6 µM 0.798281023857613 0.22767457665566 no 781 0.21235371376415 1010 689013 SGTC_333 3486-0131 40.1 µM 0.793240744482922 0.229137083196134 no 782 0.213818786511623 1082 6744690 SGTC_2122 5258151 111.688 µM 0.789999734066281 0.230080283641362 no 783 0.214763961817296 1021 2173356 SGTC_2914 7968218 45.32 µM 0.789198507169816 0.230313791546931 no 784 0.214997997184197 982 2977111 SGTC_3321 9137793 26.8275 µM 0.788963490481007 0.230382309451742 no 785 0.215066672757665 1077 4904192 SGTC_1286 0929-0070 131 µM 0.788230675714654 0.230596030976423 no 786 0.215280894518134 1071 1420408 SGTC_871 0574-0004 149 µM 0.786800118607868 0.231013564405224 no 787 0.215699442031732 1019 9551173 SGTC_1863 st057641 20.1 µM 0.786332958425353 0.231150004729677 no 788 0.215836224276311 1106 3921635 SGTC_174 3553-0389 74.3 µM 0.785059808788755 0.231522073123411 no 789 0.216209251415201 1018 738071 SGTC_3344 9148862 3.898 µM 0.784451889598188 0.231699850631854 no 790 0.216387500611838 1079 4905352 SGTC_1539 benzyladenosine 56 µM 0.783954557377883 0.231845345070144 no 791 0.216533387614702 1069 92208 A nucleotide analog. SGTC_2467 5474540 200 µM 0.782248978989579 0.232344697998629 no 792 0.217034132516379 1072 5413519 SGTC_1726 st035556 14.5795 µM 0.780897316471577 0.232740857335716 no 793 0.217431445266062 1078 5919439 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.779572210961889 0.233129597185829 no 794 0.21782135905478 970 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1137 ixabepilone 100 µM 0.778369265722732 0.233482811399735 no 795 0.218175676033357 1049 154225 A novel microtubule stabilizer. SGTC_635 k038-0028 24.7 µM 0.776975281508785 0.233892490363422 no 796 0.218586677021688 1070 4035102 SGTC_1151 3909-8316 15.3 µM 0.77378295120278 0.234832185235407 no 797 0.21952957806877 1068 800431 SGTC_2300 7976697 71.57 µM 0.77344947816856 0.234930466647544 no 798 0.219628208756354 969 2236109 SGTC_3216 9129716 49.47 µM 0.772288040889038 0.235272943652498 no 799 0.219971923450455 1036 8056934 SGTC_3089 9117425 49.47 µM 0.768805513969428 0.236301498811223 no 800 0.221004387524368 1048 9401657 SGTC_2776 terbinafine 19.92 µM 0.766745794493126 0.236910994844063 no 801 0.221616335176163 1113 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2155 5570423 76 µM 0.766601800302862 0.236953636772908 no 802 0.22165915238357 1027 797402 SGTC_1983 st071813 46.9 µM 0.766316361974903 0.237038177936323 no 803 0.221744042501968 1054 11838595 SGTC_1468 k284-1086 134 µM 0.764903614051542 0.237456849765898 no 804 0.222164470852634 1116 15996457 SGTC_2307 7538926 6.34 µM 0.764689553169809 0.237520322707383 no 805 0.222228214213 1092 96582 SGTC_3347 9188721 44.724 µM 0.764089120391734 0.23769841162165 no 806 0.222407067639397 1042 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_191 3914-0123 66.505 µM 0.764055940449058 0.237708254958592 no 807 0.222416953481154 1011 3144412 SGTC_639 0833-0042 114 µM 0.763702353174591 0.237813165913828 no 808 0.22252231907311 1086 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1769 st044406 64.4 µM 0.762779272237727 0.238087167875075 no 809 0.222797522374537 1083 670903 SGTC_2861 9024595 19.48 µM 0.762366681644519 0.238209694787357 no 810 0.222920593013718 1041 16482810 SGTC_2013 4024628 200 µM 0.761664975695059 0.238418159522096 no 811 0.223129992079596 1072 5230760 SGTC_1725 st036284 20.55 µM 0.760917375721988 0.238640368444272 no 812 0.223353209744109 1128 707914 SGTC_938 3126-1755 342 µM 0.760042058390953 0.238900682727487 no 813 0.223614722546011 1129 1777771 SGTC_1602 st001878 87.6 µM 0.759810628575147 0.238969534555954 no 814 0.223683894403637 1076 595405 YLR310C CDC25 SGTC_2177 5811945 192 µM 0.759638519686939 0.23902074506845 no 815 0.223735343767575 1114 5343475 SGTC_1820 st053765 18.6 µM 0.759525899365726 0.239054258173356 no 816 0.223769013560131 1100 3690829 SGTC_2045 5106652 78.05 µM 0.758870406505094 0.239249368092373 no 817 0.223965041647754 1100 673349 SGTC_3035 9091303 49.47 µM 0.757400405907958 0.239687235474924 no 818 0.224405006510982 1120 25237002 SGTC_2363 9053361 176 µM 0.755119830091394 0.240367412634732 no 819 0.225088542926107 1118 6469797 YMR079W SEC14 SGTC_1786 berberine 21.6 µM 0.754646920224691 0.240508588561784 no 820 0.225230431466337 1072 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_31 0508-1974 57.237 µM 0.754255728791828 0.240625403519628 no 821 0.225347840059675 1081 6810525 SGTC_3203 9113543 49.47 µM 0.753985402492024 0.240706144585933 no 822 0.225428993549597 1079 17018012 SGTC_2091 4-phenylthiadiazole 200 µM 0.753172092836462 0.240949152826923 no 823 0.225673253470422 1101 270010 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.752215126498504 0.24123525493833 no 824 0.225960849215606 1222 688664 SGTC_1926 methyl fluorone black 53.6 µM 0.751583942718619 0.241424059559317 no 825 0.226150651339531 995 72721 Reacts with homocysteine. SGTC_195 4234-0266 16.654 µM 0.750267687623527 0.241818046163438 no 826 0.22654674970566 1109 2303354 SGTC_2051 5263410 176 µM 0.748894806171628 0.242229353837614 no 827 0.226960305513204 1197 227584 SGTC_2909 7941780 10.49 µM 0.746510094013996 0.242944700883862 no 828 0.227679668149638 1134 1243215 SGTC_776 4476-4378 112 µM 0.745593293371753 0.24322001931489 no 829 0.227956567735049 1052 2892008 SGTC_1848 st056003 16.4 µM 0.745253356187656 0.243322146485207 no 830 0.228059286451677 1190 146492 SGTC_1277 0873-0036 22 µM 0.744938837687266 0.243416657769488 no 831 0.228154347592035 1156 5965735 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.744441182985873 0.243566241106226 no 832 0.228304805945132 1145 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2330 7979373 200 µM 0.743303228000336 0.243908470168699 no 833 0.228649058848608 1115 1863007 SGTC_1525 8-methoxypsoralen 92.5 µM 0.74294609529133 0.244015927878553 no 834 0.228757158314056 1169 4114 Related to psoralen; DNA damaging agent. SGTC_1038 k292-0204 154 µM 0.741379068728157 0.244487732432727 no 835 0.229231816039172 1105 4454212 SGTC_391 gliotoxin 8.33 µM 0.741010637584671 0.244598731983335 no 836 0.229343495230391 1139 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_3114 9122766 49.47 µM 0.740742906118619 0.244679410138189 no 837 0.229424669373005 1048 17176985 SGTC_3026 9090633 49.47 µM 0.740429655013725 0.244773823360641 no 838 0.229519665162208 1136 25236842 SGTC_600 1495-0418 41.6 µM 0.740347096240764 0.24479870966579 no 839 0.229544705409762 1126 5377768 SGTC_2659 sanguinarine 24.21 µM 0.740274071195953 0.244820723283423 no 840 0.229566855333387 1100 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1500 4488-1866 171 µM 0.740197388158762 0.244843840760641 no 841 0.229590116086509 1179 2900003 SGTC_2379 9035213 200 µM 0.740052411601744 0.244887549754696 no 842 0.229634096354839 1147 646551 SGTC_707 0865-0008 204 µM 0.739568939050467 0.245033342280123 no 843 0.229780797294012 1147 723043 SGTC_3329 9141233 27.5565 µM 0.739168455509605 0.245154144581512 no 844 0.229902356458855 1120 4909101 YNL103W MET4 SGTC_2662 daunorubicin 22.37 µM 0.739055793687205 0.245188133790347 no 845 0.229936559299815 1100 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2251 lansoprazole 556 µM 0.738235377472016 0.245435723472645 no 846 0.230185714150752 969 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2931 9014674 55.67 µM 0.738046305324003 0.245492801739544 no 847 0.230243155487296 1140 2996810 SGTC_1852 st056254 31.4 µM 0.738039622280353 0.245494819388494 no 848 0.230245185985692 1090 442583 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.737942182443371 0.245524238042265 no 849 0.230274792112054 1204 5024745 SGTC_403 arphamenine a 50 µM 0.737118998189602 0.245772846173842 no 850 0.230524993419683 1101 5487158 An arginine aminopeptidase inhibitor. SGTC_748 act1.228 77.9 µM 0.736460112638913 0.245971932136487 no 851 0.230725366670687 1118 4421505 YNR035C ARC35 SGTC_1564 D-Arginine 115 µM 0.736122638238673 0.246073935418684 no 852 0.230828033453556 1118 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1278 0874-0585 172 µM 0.734806475802135 0.246471968647849 no 853 0.231228681323869 1147 766306 SGTC_2817 7995342 71.43 µM 0.734518529262604 0.246559095276783 no 854 0.231316385700716 1104 18879975 SGTC_774 k060-0086 136 µM 0.734142495493944 0.246672900105098 no 855 0.23143094811335 1176 5911235 SGTC_2417 cerulenin 830 nM 0.733344065587417 0.246914634360936 no 856 0.231674302566637 1137 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_674 0498-0004 451 µM 0.732787553701741 0.247083199977607 no 857 0.231844006822146 1106 4231473 SGTC_2443 5493264 126.67 µM 0.732644825686393 0.247126441739649 no 858 0.231887541847196 1127 5340055 SGTC_3123 9126162 49.47 µM 0.731255307929678 0.247547630070372 no 859 0.232311611623145 1217 25239884 SGTC_2008 4012253 172 µM 0.728969288660506 0.248241398102134 no 860 0.233010224423163 1162 603940 SGTC_3081 9117243 49.47 µM 0.728836017824515 0.248281875496378 no 861 0.233050988260394 1142 45595589 SGTC_190 3970-0790 3.722 µM 0.728597560087737 0.248354309333133 no 862 0.233123935721909 1125 2832352 SGTC_2237 6667747 47.222 µM 0.728253749999043 0.248458764788543 no 863 0.233229134210606 1079 729940 YDL015C TSC13 SGTC_3311 9131146 2.8755 µM 0.728186024593453 0.248479343698728 no 864 0.2332498598332 1098 4900406 YPR165W RHO1 SGTC_3221 9128209 49.47 µM 0.727587328670969 0.248661301775859 no 865 0.233433119809471 1140 16460723 SGTC_1019 4262-0212 3.4 µM 0.727381522809146 0.248723867509618 no 866 0.233496135136137 1218 4677213 SGTC_1174 0739-0097 51.1 µM 0.727217097942668 0.248773859293107 no 867 0.233546486869758 1137 728447 SGTC_1237 0330-0133 46.1 µM 0.724446598344107 0.249617006706708 no 868 0.234395800324646 1101 X1237 YHR072W ERG7 SGTC_2142 5622915 118.518 µM 0.724282481375532 0.249667000078499 no 869 0.234446164940875 1132 5322196 SGTC_2836 9010338 19.48 µM 0.72367691254387 0.249851514684574 no 870 0.234632055180995 1093 2994051 SGTC_2364 9055074 200 µM 0.722721633612938 0.250142731779291 no 871 0.234925460861499 1135 6470630 SGTC_1550 gossypolone 36.6 µM 0.721910410552472 0.250390174685906 no 872 0.235174780134456 1174 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1557 sumaresinolic acid 42.3 µM 0.7216682436607 0.250464066658898 no 873 0.235249235414192 1110 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2440 5628896 157.78 µM 0.72108030340014 0.250643511948222 no 874 0.235430054387566 1155 5522048 SGTC_1711 st032263 62.8 µM 0.720490388723314 0.250823628267195 no 875 0.235611557647239 1145 3958979 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.71832323197276 0.251485905505431 no 876 0.236279004407509 1176 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_3149 9097855 49.47 µM 0.717787423932254 0.251649789351386 no 877 0.236444184392504 1141 25236625 YMR079W SEC14 SGTC_2159 5658611 73.75 µM 0.717641506679382 0.251694429808412 no 878 0.236489179067052 1189 793844 SGTC_2516 gossypol 71.55 µM 0.717420139464677 0.25176216065207 no 879 0.236557448297034 1184 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_378 3970-0959 8.33 µM 0.716098496970258 0.252166738502072 no 880 0.236965265901795 1144 6615653 SGTC_1375 2910-0797 186 µM 0.715648948565701 0.252304431233292 no 881 0.23710407053149 1146 742508 SGTC_703 3875-0075 71.8 µM 0.714728294191381 0.25258654325576 no 882 0.237388475384299 1206 2850814 SGTC_3339 9145883 14.936 µM 0.711931403546185 0.253444600180178 no 883 0.238253627342153 1106 2030670 SGTC_2601 securinine 100 µM 0.711917112114413 0.253448988572868 no 884 0.238258052489486 1153 442872 A GABA receptor antagonist. SGTC_288 1315-0019 35.1 µM 0.7118692011974 0.253463700610446 no 885 0.238272887781305 1190 6811474 SGTC_2580 diallyl disulphide 81.36 µM 0.710871464316427 0.253770178299538 no 886 0.238581945226492 1155 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_85 0868-0259 160.055 µM 0.709458523458477 0.254204528018331 no 887 0.239019990729199 1108 83173 SGTC_3183 9108214 49.47 µM 0.707854826735432 0.254697989602252 no 888 0.239517707393045 1086 4974831 SGTC_1485 3909-9022 254 µM 0.707542124238084 0.254794267366633 no 889 0.239614822325667 1203 714516 SGTC_235 0330-0087 5 mM 0.706508243475852 0.255112723807709 no 890 0.239936064048587 1211 46494818 YHR062C RPP1 SGTC_2897 9048598 12.99 µM 0.705786022096259 0.255335306220504 no 891 0.240160607959238 1176 6467404 SGTC_404 fumagillin 50 µM 0.703611719779922 0.256006019786888 no 892 0.240837305383053 1165 12015870 A methionine aminopeptidase binder. SGTC_1366 1683-0113 21.9 µM 0.702424175613903 0.256372732814399 no 893 0.241207336479789 1197 708623 SGTC_2968 9090663 33.37 µM 0.70236909549034 0.256389748168755 no 894 0.24122450658611 1142 25236811 SGTC_2244 6635614 200 µM 0.699676593943068 0.25722223283694 no 895 0.242064648466212 1075 836499 SGTC_1763 st044482 94.5 µM 0.69843274877303 0.257607286742061 no 896 0.242453300924645 1176 88505 SGTC_467 ro 31-8220 72.8 µM 0.698232234781881 0.257669387339112 no 897 0.242515985245923 1151 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_113 0099-0221 2.5 µM 0.697249386701859 0.2579738947038 no 898 0.242823368356746 1199 89219 SGTC_559 1550-0661 158 µM 0.69702187132014 0.258044410435193 no 899 0.242894553224987 1200 5830875 SGTC_418 lividomycin a 100 µM 0.696729676149747 0.258134987571869 no 900 0.242985991624273 1209 72394 An antibiotic. SGTC_2297 7971671 152.32 µM 0.696194760787721 0.258300847874591 no 901 0.243153434153339 1209 909016 SGTC_1523 st012844 44.7 µM 0.69592103487977 0.258385742961644 no 902 0.243239141661913 1217 4274103 SGTC_1160 4092-0570 10.5 µM 0.695150961866697 0.258624655805959 no 903 0.24348035014246 1199 4994975 SGTC_3145 9085516 49.47 µM 0.69300108062988 0.259292254895078 no 904 0.244154436672997 1208 25236195 SGTC_1964 st076914 61 µM 0.6924443779741 0.259465271896465 no 905 0.244329152417469 1216 24208661 SGTC_838 0109-0203 71.4 µM 0.689124909555981 0.260498162201816 no 906 0.245372332865604 1215 759422 SGTC_1324 1418-0026 34.4 µM 0.687119745324521 0.261123116019551 no 907 0.246003636193699 1217 1372513 SGTC_1591 genipin 88.4 µM 0.684364271930131 0.261983175663343 no 908 0.246872585498203 1196 442424 A DNA cross-linking agent. SGTC_4 0960-0234 25.671 µM 0.684304608319433 0.262001814381327 no 909 0.246891418805222 1207 6821112 SGTC_425 3825-7017 13.1 µM 0.683776973112388 0.262166675487948 no 910 0.247058004641224 1249 3397440 SGTC_694 1315-0438 43.2 µM 0.682522264333094 0.262558926159859 no 911 0.247454384704725 1154 6793154 SGTC_2415 st077333 57.7 µM 0.681946261021349 0.262739098518176 no 912 0.247636465965473 1261 2766255 SGTC_52 0329-0193 875 nM 0.681893592337455 0.262755576302708 no 913 0.247653118711326 1281 3739292 SGTC_2457 5731572 11.68 µM 0.680781966801454 0.263103479785852 no 914 0.248004731143546 1251 2865357 SGTC_2999 9069765 71.4286 µM 0.680291545043315 0.2632570410126 no 915 0.248159938510656 1236 2097066 SGTC_1618 st003135 44.5 µM 0.679226196353649 0.263590781444878 no 916 0.248497275639593 1179 1270615 SGTC_2312 7706453 155.7 µM 0.679194983347362 0.263600562757868 no 917 0.248507162758903 1241 976098 SGTC_1665 st014639 11.4 µM 0.678848826658202 0.263709051327316 no 918 0.248616826372455 1288 981133 YIL048W NEO1 SGTC_965 1291-5240 308 µM 0.67715559279332 0.264240053761337 no 919 0.249153619838224 1215 2834598 SGTC_1512 0259-0544 12.2 µM 0.676707045805175 0.264380810404764 no 920 0.249295922598155 1222 18476 SGTC_1730 st033808 45.1 µM 0.676048573434859 0.264587511967407 no 921 0.249504903014966 1220 1045166 SGTC_3239 9133757 49.47 µM 0.675852890263062 0.264648954862944 no 922 0.249567025229745 1225 17036923 SGTC_1314 1222-0010 41.1 µM 0.675240535767588 0.264841275981296 no 923 0.249761478355118 1229 3526027 SGTC_2060 5238662 140 µM 0.674490759476595 0.265076853635813 no 924 0.249999679274407 1202 790130 SGTC_890 0929-0006 47.2 µM 0.673106480592993 0.265512069766034 no 925 0.250439775657053 1223 1378169 SGTC_1261 0712-0010 12.7 µM 0.670440538417636 0.266351259858081 no 926 0.251288499865825 1252 2840123 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.669307149813586 0.266708436125594 no 927 0.251649783428728 1271 368090 SGTC_203 k066-0004 30.888 µM 0.668472574738348 0.26697159893834 no 928 0.251915991261581 1301 6795412 SGTC_2024 5144227 134 µM 0.667759139577043 0.267196667175168 no 929 0.252143676379902 1234 3475211 SGTC_2826 7992541 19.48 µM 0.666928301573529 0.267458893275192 no 930 0.25240896608732 1299 2985066 SGTC_1288 0973-0013 65.5 µM 0.666290665824668 0.267660229562996 no 931 0.252612665318562 1275 4315430 SGTC_866 0495-0101 262 µM 0.665615144041968 0.267873611832388 no 932 0.252828562055595 1213 635694 SGTC_401 neomycin 50 µM 0.66249948260552 0.268858887458385 no 933 0.253825583153198 1225 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_3025 9087895 49.47 µM 0.662372299594171 0.268899145577313 no 934 0.253866325902594 1253 17173641 SGTC_844 0330-0132 15.3 µM 0.661846705734224 0.26906554753369 no 935 0.25403473493697 1238 2828079 SGTC_597 k018-0003 82.8 µM 0.66165924660113 0.269124909217473 no 936 0.254094814145278 1325 6786234 SGTC_2435 5706476 10.6 µM 0.657688612553918 0.270383810366949 no 937 0.255369120558086 1275 5725375 SGTC_341 1486-1430 230 µM 0.657203150040321 0.270537929368467 no 938 0.255525150198305 1224 2054753 YPL210C SRP72 SGTC_2771 fluoxetine 41.05 µM 0.657076575773645 0.270578119908712 no 939 0.255565839869895 1266 3386 A selective serotonin reuptake inhibitor. SGTC_3309 9129340 25.759 µM 0.654663545508319 0.271344888155986 no 940 0.256342200520757 1284 17158987 SGTC_1386 3228-0095 33.8 µM 0.653285376035926 0.271783302731349 no 941 0.256786159226118 1265 870181 SGTC_1087 pterostilbene 9.05 µM 0.651468401840319 0.272361845322599 no 942 0.257372084025017 1314 5281727 Similar to reservatol, lowers cholesterol. SGTC_2689 tacrolimus 100 µM 0.650855232703954 0.272557222423343 no 943 0.257569971075394 1277 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_184 1494-0393 24.714 µM 0.650532130654315 0.272660202004605 no 944 0.257674277039967 1249 3090647 SGTC_500 h-89 112 µM 0.649995238116169 0.272831363910323 no 945 0.257847648765102 1314 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3214 9129694 49.47 µM 0.649478731112602 0.272996077170166 no 946 0.258014494765542 1237 17158655 SGTC_1526 st051518 75 µM 0.648452518954046 0.273323480802358 no 947 0.258346155657359 1260 673993 SGTC_2190 6049624 200 µM 0.647440946350857 0.273646404029827 no 948 0.258673301276307 1212 2265554 SGTC_658 3253-0951 102 µM 0.64637560874653 0.273986694554048 no 949 0.259018066373282 1273 1184878 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.64472755886979 0.274513526923172 no 950 0.259551876897339 1297 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1484 3473-2379 286 µM 0.644281446819124 0.274656221548031 no 951 0.259696472166144 1367 671917 SGTC_2351 9026858 72.31 µM 0.639466017188312 0.276198822574666 no 952 0.261259907009735 1224 1409300 SGTC_252 miconazole 1.30953 nM 0.638582917241787 0.276482180347163 no 953 0.261547148616387 1245 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1004 4084-0029 199 µM 0.63788681735162 0.276705636358027 no 954 0.26177367983191 1303 716894 YLR208W SEC13 SGTC_1410 3909-8106 77.9 µM 0.636893926830605 0.277024518598175 no 955 0.262096969461157 1318 1039210 SGTC_2748 diazoxide 86.69 µM 0.634786112067431 0.277702071790524 no 956 0.262783961101567 1269 3019 A potassium channel activatior. SGTC_1862 st057513 3.81 µM 0.634639809765221 0.277749130420392 no 957 0.26283167898484 1269 5393163 SGTC_149 3970-0822 46.1 µM 0.63309087917907 0.27824758790528 no 958 0.263337149039121 1356 3114250 YBL034C STU1 SGTC_79 0052-0007 94.094 µM 0.632779432291053 0.278347866490983 no 959 0.263438844922934 1342 2801472 SGTC_1231 0242-0792 125 µM 0.632712755507259 0.278369337138897 no 960 0.263460619312319 1281 3707635 SGTC_2434 5670830 169.91 µM 0.631438473807312 0.27877982471978 no 961 0.26387693321984 1285 1549830 SGTC_804 1595-0054 20.9 µM 0.631195416455587 0.278858154842616 no 962 0.263956379284028 1295 761523 Stimulates phospholipase C. SGTC_548 1436-0017 110 µM 0.630862429283496 0.278965484043004 no 963 0.264065239722436 1353 9677137 SGTC_1574 spiramycin 23.7 µM 0.630251518116601 0.279162446587715 no 964 0.26426501876483 1266 6419898 An antibiotic and protein synthesis inhibitor. SGTC_572 0960-0087 17.7 µM 0.629756238263413 0.279322178295463 no 965 0.264427040740798 1267 6796365 SGTC_1146 3579-1023 7 µM 0.629717514679105 0.279334668832083 no 966 0.264439710601855 1372 X1146 SGTC_923 1900-2434 73.3 µM 0.629542896558076 0.279390996380209 no 967 0.26449684725328 1272 5910570 SGTC_2102 5377816 72.7585 µM 0.62879139996835 0.279633473805319 no 968 0.26474281550599 1324 1379702 SGTC_2239 6685329 187.64 µM 0.627733054395412 0.279975132056584 no 969 0.265089413958697 1321 805680 SGTC_1491 4138-0063 26.5 µM 0.627024448154944 0.280203999484104 no 970 0.265321604748717 1269 23883227 SGTC_284 0988-0104 32.6 µM 0.624127193856109 0.28114070375483 no 971 0.266272028057916 1301 4666532 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.623149613048905 0.281457103944362 no 972 0.266593104736595 1314 3256 An antibiotic and ribosome inhibitor. SGTC_2739 tacrine 100.86 µM 0.621718940127378 0.281920459728108 no 973 0.267063347644854 1316 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2031 5180455 200 µM 0.621682831525697 0.281932159068459 no 974 0.26707522147204 1269 29949 SGTC_3337 9144342 33.5465 µM 0.620851499104341 0.282201578965369 no 975 0.267348667631335 1351 17682949 SGTC_2917 7979103 53.79 µM 0.618667410991854 0.282909992532839 no 976 0.268067741531216 1341 2980565 SGTC_456 gingerol 170 µM 0.618577021264737 0.282939329022866 no 977 0.268097521779553 1352 442793 A herb. SGTC_1788 fluconazole 20 µM 0.617548610466532 0.283273208288138 no 978 0.268436464318956 1295 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2340 7987427 183.45 µM 0.617119507848983 0.283412574680541 no 979 0.268577951183658 1317 2239331 SGTC_1021 4476-0760 85.3 µM 0.615891919707276 0.283811459176916 no 980 0.268982927441701 1283 746768 SGTC_893 0958-0369 48.9 µM 0.615205893857858 0.284034488958082 no 981 0.269209377977183 1353 6819948 SGTC_2829 7992743 58.44 µM 0.613440768822299 0.284608723348819 no 982 0.269792468017081 1324 16462845 SGTC_453 enantio-paf c16 10 µM 0.613212287795461 0.284683093804667 no 983 0.269867990464104 1303 13871343 A lipid and platelet activating factor SGTC_45 0kpi-0036 14.9 µM 0.609480675161647 0.285899042890198 no 984 0.27110293903345 1332 2795021 SGTC_2072 5231554 129 µM 0.609092203414453 0.286025768501014 no 985 0.271231662563255 1363 789545 SGTC_2952 9073731 13.78 µM 0.607238477580007 0.286630850417149 no 986 0.271846330199721 1314 16457353 SGTC_2729 fluphenazine 10.66 µM 0.606358032228733 0.28691845251656 no 987 0.272138515223816 1254 3372 An atypical antipsychotic. SGTC_298 1391-0729 10 µM 0.605426413025244 0.287222919618013 no 988 0.272447852720283 1307 3237558 SGTC_1875 nocodazole 6 µM 0.604781223134946 0.287433866915265 no 989 0.272662185706811 1329 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_51 1013-0126 23.419 µM 0.603290967041394 0.287921391723819 no 990 0.273157570522003 1448 1627850 SGTC_1258 0671-0043 57.1 µM 0.601279848238157 0.288579930722595 no 991 0.273826804651328 1316 4298767 SGTC_769 0302-0231 76 µM 0.599429540043914 0.289186438485283 no 992 0.274443241567646 1347 571869 YER009W NTF2 SGTC_1553 gossypol 38.6 µM 0.598950868058228 0.289343438659612 no 993 0.274602824315561 1277 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1063 disulfiram 1.84 µM 0.598237175376528 0.289577597889257 no 994 0.274840844743973 1329 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_878 0828-0289 13.7 µM 0.596717756268786 0.290076408306245 no 995 0.275347917815596 1356 745350 YLR208W SEC13 SGTC_568 1193-0097 7.48 µM 0.595603449130568 0.290442480211101 no 996 0.275720085974197 1271 3646150 SGTC_2163 5671233 125 µM 0.595512975875679 0.290472211951932 no 997 0.275750314043967 1443 701023 SGTC_1579 chlormadinone acetate 49.4 µM 0.595046087657601 0.290625665564546 no 998 0.275906332212865 1382 45114258 A steroidal progestin. SGTC_1791 st048313 56.1 µM 0.593872609875336 0.291011523536563 no 999 0.276298659949472 1310 1204976 SGTC_3126 9127922 49.47 µM 0.593673543400166 0.291077003464946 no 1000 0.276365240802722 1362 45595682 SGTC_1707 st032323 6.317 µM 0.592664831966355 0.291408909686027 no 1001 0.276702740827558 1315 3132057 YMR211W DML1 SGTC_1162 k048-0130 20.1 µM 0.592382420378023 0.291501865969857 no 1002 0.276797267768273 1330 6797406 SGTC_2007 4011539 71.82 µM 0.591310704037621 0.29185474909626 no 1003 0.277156129425349 1371 45595301 SGTC_2725 haloperidol 53.21 µM 0.591081930902997 0.291930102796538 no 1004 0.277232763035588 1313 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1549 4'-methoxyflavonol 74.6 µM 0.58774916642116 0.293028880645733 no 1005 0.278350334454032 1345 97141 SGTC_2113 5491891 107.031 µM 0.585479967336156 0.293778108171054 no 1006 0.279112516340431 1339 789979 SGTC_2840 9008771 71.43 µM 0.584707672864356 0.294033300713511 no 1007 0.279372146973458 1356 2992978 SGTC_2201 6605497 169.863 µM 0.584072610660165 0.294243223762663 no 1008 0.279585730608736 1384 670741 SGTC_588 3970-1144 52.9 µM 0.58404980540094 0.294250763444898 no 1009 0.279593401930247 1337 1888707 SGTC_861 0443-0273 110 µM 0.583865804887655 0.29431159940536 no 1010 0.279655300474021 1390 6149169 SGTC_591 4299-0174 154 µM 0.583726561383783 0.294357641248025 no 1011 0.279702146992856 1370 5509088 SGTC_525 k781-2675 26.7 µM 0.58314959278939 0.29454845539904 no 1012 0.279896300534664 1400 3651118 YDL195W SEC31 SGTC_2255 7941087 197.44 µM 0.583127293727807 0.294555831255265 no 1013 0.27990380562004 1433 935561 SGTC_1439 4092-1168 46 µM 0.582891973275576 0.294633673349761 no 1014 0.279983012214652 1370 2886240 SGTC_1968 st069590 43.6 µM 0.582561629920224 0.294742964256906 no 1015 0.280094220933478 1332 6384066 SGTC_244 nsc-207895 1.295 µM 0.582484965956707 0.29476833046079 no 1016 0.280120032598735 1282 42640 SGTC_3059 1327-0034 3 µM 0.581490289776124 0.295097535347517 no 1017 0.28045503036957 1322 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1609 st001574 46.4 µM 0.581449545399474 0.29511102399662 no 1018 0.28046875683384 1331 3960012 SGTC_2420 aureobasidin a 50 nM 0.581090773413469 0.29522980968369 no 1019 0.28058963836859 1499 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3077 9117319 49.47 µM 0.575122205956023 0.297209160862392 no 1020 0.28260432539926 1379 17154678 SGTC_1118 chelidonine 707.474 nM 0.566891114624559 0.299948735574237 no 1021 0.285394080658211 1416 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_547 1120-0019 610 nM 0.565867397087077 0.300290259623877 no 1022 0.285741963106921 1402 3676939 SGTC_394 menadione 8.33 µM 0.565751554391455 0.300328917158682 no 1023 0.285781341784184 1378 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1043 0916-0009 19.3 µM 0.565216117650096 0.300507625436918 no 1024 0.285963387570232 1455 3101130 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.564541205363076 0.300732953704396 no 1025 0.286192932834512 1294 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1988 st071872 53.4 µM 0.564029844022567 0.300903729106043 no 1026 0.286366910833266 1421 16414116 SGTC_579 4491-1009 110 µM 0.562009260657109 0.301578955144322 no 1027 0.287054854796569 1481 1271041 SGTC_741 4582-0002 126 µM 0.559888729468063 0.302288313212064 no 1028 0.287777668377598 1366 2912688 SGTC_2904 7225135 42.03 µM 0.559330418117281 0.30247520341596 no 1029 0.287968119731796 1455 4446116 SGTC_3192 9110362 49.47 µM 0.556697557001099 0.303357229648889 no 1030 0.288867043175326 1470 16649480 SGTC_125 0133-0007 11.75 µM 0.555810870366162 0.303654534169243 no 1031 0.289170076778981 1478 26541 SGTC_2533 agelasine 13.65 µM 0.554573972528299 0.304069481026055 no 1032 0.289593047893969 1509 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1252 0493-0875 34.8 µM 0.55348400965941 0.304435344375069 no 1033 0.289966013527616 1396 3960963 SGTC_1341 1486-1360 280 µM 0.553266216788874 0.304508473491923 no 1034 0.290040565308802 1383 3976547 SGTC_26 0302-0163 425.158 µM 0.552408489876253 0.304796551601902 no 1035 0.2903342576148 1416 3100915 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.55230883796774 0.304830028771403 no 1036 0.290368388224211 1450 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2612 dictamnine 15.46 µM 0.550945690999064 0.30528812978955 no 1037 0.290835452249179 1419 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3121 9125696 49.47 µM 0.549656192485572 0.30572176130526 no 1038 0.291277604608839 1460 1235365 SGTC_689 0833-0039 98 µM 0.548625770460954 0.306068466759479 no 1039 0.291631148364856 1427 5374726 SGTC_968 1309-0633 340 µM 0.547806606528419 0.306344214360778 no 1040 0.291912350900809 1411 3761976 SGTC_2089 5281248 129.67 µM 0.547457391474381 0.306461800769574 no 1041 0.292032267799645 1409 2737878 SGTC_2191 5911152 200 µM 0.546992511071378 0.306618364513637 no 1042 0.292191938578222 1419 2875902 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.546070830417918 0.306928875084332 no 1043 0.29250862491468 1417 6708784 An antioxidant flavonoid SGTC_1753 st043925 64 µM 0.544407351833593 0.307489645043774 no 1044 0.293080593903201 1444 670181 SGTC_2078 5212016 200 µM 0.544297104432276 0.307526826115798 no 1045 0.293118519593832 1388 1899708 SGTC_1172 0370-0043 85 µM 0.543710765242478 0.307724602949487 no 1046 0.293320261615445 1459 376585 SGTC_940 3232-1287 54.8 µM 0.543374092186641 0.307838190688692 no 1047 0.293436129958895 1396 1585493 YIL048W NEO1 SGTC_3162 9099653 49.47 µM 0.542409424685764 0.308163754987894 no 1048 0.293768244260646 1407 25237511 SGTC_1689 st020265 53.493 µM 0.539142988051134 0.309267260216323 no 1049 0.294894097717219 1492 5758320 YPR016C TIF6 SGTC_708 3448-5400 146 µM 0.53749649653392 0.309824150642287 no 1050 0.295462352150246 1406 3462195 SGTC_1367 1812-0510 76.9 µM 0.536800205401568 0.310059787647531 no 1051 0.295702814888593 1439 1142582 YDR527W RBA50 SGTC_16 erodoxin 22.806 µM 0.536401166446208 0.310194864535758 no 1052 0.295840662713494 1444 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_118 0083-0097 135.343 µM 0.535908181689239 0.310361777963436 no 1053 0.29601100481844 1471 5207356 SGTC_2834 9001755 58.44 µM 0.535736204388749 0.310420014758928 no 1054 0.296070439103466 1464 2989575 SGTC_3195 9113082 49.47 µM 0.532873931265642 0.311389965255193 no 1055 0.297060425949844 1427 17018038 SGTC_652 0437-0092 114 µM 0.532796039870269 0.311416378988097 no 1056 0.297087387732204 1398 3091274 SGTC_576 1073-0113 22.7 µM 0.53279119696579 0.311418021296361 no 1057 0.297089064120384 1538 5439563 SGTC_382 3229-0966 23.2 µM 0.531875643607053 0.311728567828413 no 1058 0.297406063764976 1512 5722370 SGTC_3266 9136860 49.47 µM 0.530899846652023 0.312059695832047 no 1059 0.297744092023598 1386 4871271 YPR165W RHO1 SGTC_1279 0874-0590 65.2 µM 0.525577312158859 0.313868519151052 no 1060 0.299590961841597 1466 3523074 SGTC_3327 9140648 26.9345 µM 0.524456029428989 0.314250151707623 no 1061 0.29998069752715 1478 8029710 SGTC_2988 9073640 71.4286 µM 0.522020254506217 0.315079860447996 no 1062 0.300828114137027 1496 9102229 SGTC_1185 1319-0113 81.3 µM 0.521906855756903 0.315118510745357 no 1063 0.300867592346162 1485 4672763 SGTC_2656 pseudo-anisatin 100 µM 0.52139623113151 0.315292574718622 no 1064 0.301045388203721 1460 6708809 A neurotoxin. SGTC_3164 9100705 49.47 µM 0.520646141038892 0.315548343094491 no 1065 0.301306650072857 1516 17174235 SGTC_2156 5649887 115 µM 0.520493228089894 0.31560049474306 no 1066 0.301359923298218 1538 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_596 1155-0152 116 µM 0.52043879937374 0.315619058787666 no 1067 0.301378886700312 1443 280313 SGTC_344 k064-0035 6.43 µM 0.520130759079848 0.315724131097309 no 1068 0.301486220535969 1413 5088750 SGTC_1399 3562-5772 25 µM 0.516409117141103 0.316994755365894 no 1069 0.302784349711999 1420 23847490 SGTC_959 1222-0044 107 µM 0.516352871998319 0.31701397491322 no 1070 0.302803987516072 1490 6083612 SGTC_2955 9076254 12.21 µM 0.515629552107525 0.317261184789487 no 1071 0.30305658305746 1465 16459619 SGTC_1850 st056238 17 µM 0.51376131583683 0.317900071209089 no 1072 0.303709438518699 1450 5393177 SGTC_2707 st078556 66.6 µM 0.511921848003948 0.318529649640234 no 1073 0.304352853375957 1506 17250899 SGTC_328 k915-0120 63.5 µM 0.511298305210655 0.318743183217661 no 1074 0.304571095785709 1534 6624543 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.511062672461815 0.31882389183749 no 1075 0.304653586288002 1503 688788 SGTC_175 3793-3120 23.7 µM 0.508689022472071 0.319637390060007 no 1076 0.305485109099687 1455 5322297 SGTC_3003 9075612 71.4286 µM 0.508103498673322 0.319838194701825 no 1077 0.30569038088979 1472 6501993 SGTC_2786 7743617 45.45 µM 0.507787328133626 0.319946646947201 no 1078 0.305801248738824 1375 583674 SGTC_629 3448-6466 76.7 µM 0.506903227521932 0.320249991202003 no 1079 0.306111360482946 1467 573744 SGTC_2843 9000894 45.46 µM 0.506166928875803 0.32050271476619 no 1080 0.306369734538562 1374 2242070 SGTC_2211 7117706 200 µM 0.504732801837933 0.320995196459196 no 1081 0.306873259469852 1515 822771 SGTC_831 k061-1017 217 µM 0.504040338042444 0.321233102570403 no 1082 0.307116515497826 1561 1240153 SGTC_1304 1165-0502 251 µM 0.503853661877622 0.321297250470904 no 1083 0.307182107616926 1498 767425 SGTC_2450 5739737 12.93 µM 0.50323178039116 0.321510987293657 no 1084 0.307400661667964 1466 2262825 SGTC_2388 9080168 200 µM 0.49867531696406 0.323078814845823 no 1085 0.309004068039285 1431 15943073 SGTC_1933 st074711 15.9 µM 0.496586801474323 0.323798503502755 no 1086 0.309740231211177 1446 17250958 SGTC_374 0880-0231 82.3 µM 0.496396838701039 0.323863996172144 no 1087 0.309807227519943 1462 6833587 SGTC_875 0709-0210 25.7 µM 0.493097013838732 0.325002531645934 no 1088 0.310972020368323 1523 6251364 SGTC_3350 9150499 3.57 µM 0.492736545939926 0.325127002863371 no 1089 0.311099375677881 1455 4910996 YPR165W RHO1 SGTC_1626 st003712 1.76 µM 0.491273141014388 0.325632523624817 no 1090 0.31161663697464 1532 24207035 SGTC_2152 5568786 200 µM 0.490871488110136 0.325771327353989 no 1091 0.311758672008718 1481 5399883 SGTC_2716 st080858 38.6235 µM 0.490386303461796 0.325939030303992 no 1092 0.311930283412313 1495 5296050 SGTC_1835 st008666 49.2 µM 0.488848679233399 0.326470739092737 no 1093 0.312474415781712 1436 690455 SGTC_1778 st046819 58.9 µM 0.488539373743686 0.326577739248185 no 1094 0.312583921850053 1516 671715 SGTC_2000 st075254 36.4 µM 0.487809777146631 0.326830190081026 no 1095 0.31284229271569 1470 17234175 SGTC_713 1488-1073 324 µM 0.487584137682294 0.326908280613157 no 1096 0.312922216680188 1501 3312542 SGTC_3263 9137018 49.47 µM 0.487425151427289 0.326963307993234 no 1097 0.312978536630451 1426 43844957 SGTC_508 roscovitine 141 µM 0.487216591954283 0.327035499067003 no 1098 0.313052424221042 1556 160355 A CDKinase inhibitor. SGTC_1829 berberine 14.4 µM 0.486882857484134 0.327151031857926 no 1099 0.313170673913114 1588 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_316 k060-0003 58.6 µM 0.4854406487887 0.32765048856385 no 1100 0.313681901981931 1535 6152314 SGTC_1056 3448-1962 115 µM 0.482077272551949 0.328816469627281 no 1101 0.314875527156543 1537 715507 SGTC_3261 9137475 49.47 µM 0.481387118296755 0.329055931917675 no 1102 0.315120695141471 1491 17027690 SGTC_2365 9042475 200 µM 0.48011031670547 0.329499127707751 no 1103 0.315574476377472 1490 6464479 SGTC_2028 5153890 36.43 µM 0.479473305566609 0.329720332866026 no 1104 0.315800977183745 1497 2830968 YPR165W RHO1 SGTC_2890 9046729 58.44 µM 0.478945285061806 0.329903735670101 no 1105 0.315988776852188 1436 903329 SGTC_1037 k284-1091 78.7 µM 0.477053377848261 0.330561206827192 no 1106 0.316662056237868 1494 3334711 SGTC_297 0986-0032 24 µM 0.475868097808532 0.330973379299926 no 1107 0.317084175696075 1490 2847425 SGTC_1939 st074455 53.6 µM 0.473290882208872 0.331870293963935 no 1108 0.318002833114512 1639 1644229 SGTC_2598 perillyl alcohol 100 µM 0.472990498752507 0.331974895343427 no 1109 0.31810997888558 1569 10819 An apoptosis inducer. SGTC_2268 7933382 153.85 µM 0.472467066457014 0.332157199455792 no 1110 0.318296721803114 1507 935025 YOR257W CDC31 SGTC_148 3253-0744 288.01 µM 0.470354935133162 0.332893228345531 no 1111 0.319050727541927 1483 6893655 SGTC_3150 9097574 49.47 µM 0.46970252885721 0.333120707225673 no 1112 0.31928378043554 1640 17217476 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.468247250545015 0.333628350076704 no 1113 0.319803892925771 1521 4620898 SGTC_649 1123-0311 367 µM 0.468162806507604 0.333657815944483 no 1114 0.319834083885354 1518 693629 YIL048W NEO1 SGTC_1830 st055982 50.3 µM 0.467472977891525 0.333898562871354 no 1115 0.320080760406031 1588 455313 An antimicrobial agent. SGTC_1946 st076057 65.1 µM 0.467335864716595 0.333946422871289 no 1116 0.32012980032792 1462 953009 SGTC_1799 st045822 46.1415 µM 0.46626742816839 0.334319458160381 no 1117 0.32051204512371 1606 3674992 SGTC_2487 5918373 44.05 µM 0.466238367892492 0.334329606589989 no 1118 0.320522444415809 1572 2876279 SGTC_913 3487-1245 167 µM 0.465438609655048 0.33460894566238 no 1119 0.320808695166085 1457 4016153 SGTC_682 0kpi-0099 17 µM 0.465142249116573 0.334712481553592 no 1120 0.320914796075894 1511 1714895 YML126C ERG13 SGTC_1215 3852-0577 11.2 µM 0.465032383945872 0.334750867010935 no 1121 0.320954132946149 1645 2884876 SGTC_1448 4255-0083 152 µM 0.464754710110828 0.334847890323284 no 1122 0.321053562125845 1676 5399660 SGTC_1816 st051957 91.6 µM 0.464706186788772 0.334864846215835 no 1123 0.32107093862763 1535 674121 SGTC_2560 caryophyllene 100 µM 0.464415537559148 0.334966417147506 no 1124 0.32117503011621 1542 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2260 7964312 200 µM 0.463797233667085 0.335182531161329 no 1125 0.321396512744104 1630 231951 SGTC_230 MPP+ 141.667 µM 0.463663299084221 0.335229352130802 no 1126 0.321444497821712 1486 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3122 9126309 49.47 µM 0.461819186478832 0.33587427864519 no 1127 0.322105495346128 1552 17591206 SGTC_1613 st002381 52.1 µM 0.460534256767802 0.336323932675191 no 1128 0.322566394251432 1515 551167 SGTC_2314 7727897 200 µM 0.45995627707416 0.336526269882025 no 1129 0.322773802141724 1499 900724 SGTC_976 1348-1067 47.6 µM 0.455583146230771 0.338058731670135 no 1130 0.324344882446897 1551 5310671 YGL099W LSG1 SGTC_3254 9136651 49.47 µM 0.45544462955667 0.338107315650361 no 1131 0.324394696927859 1514 16454030 SGTC_3191 9110352 49.47 µM 0.455369759086821 0.338133577188561 no 1132 0.324421623757179 1584 17122424 SGTC_2715 st079500 56.4 µM 0.454984247011582 0.338268811727461 no 1133 0.324560285980251 1502 28246688 SGTC_499 genistein 192 µM 0.454709534602905 0.338365191367248 no 1134 0.324659110265937 1620 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1777 st045864 34.765 µM 0.454593770866875 0.338405808893905 no 1135 0.324700758491301 1542 4691462 SGTC_2197 6588183 93.1375 µM 0.450036373023233 0.340006333400293 no 1136 0.32634210693966 1543 884136 SGTC_739 1486-1183 203 µM 0.449369638158667 0.340240728592189 no 1137 0.326582514948775 1647 4346692 SGTC_613 3914-0030 117 µM 0.448353000828099 0.340598253215398 no 1138 0.326949227725045 1504 1145395 SGTC_36 0335-0881 14.2 µM 0.448209263915364 0.340648813276457 no 1139 0.327001088779518 1580 23828853 SGTC_3052 9092717 49.47 µM 0.447639565681554 0.340849235173205 no 1140 0.327206671836307 1544 25237534 SGTC_127 0180-0333 59.125 µM 0.446751213195687 0.341161850425303 no 1141 0.327527350056192 1546 771601 SGTC_2935 9038016 29.96 µM 0.445575776186978 0.341575659611202 no 1142 0.327951855898488 1563 6463195 SGTC_1653 st012112 65 µM 0.443561090913882 0.342285366556999 no 1143 0.328679970936684 1613 720429 SGTC_2704 st078022 71.1 µM 0.443165911314261 0.342424640715893 no 1144 0.328822866810323 1684 54697681 SGTC_2139 5578692 56.4705 µM 0.441986745256088 0.342840344542982 no 1145 0.329249398750971 1657 650991 YMR113W FOL3 SGTC_68 0986-0284 82.829 µM 0.441078978457693 0.343160498838693 no 1146 0.329577910735801 1491 423278 YIL048W NEO1 SGTC_2954 9074818 52.69 µM 0.441061348580518 0.343166717719468 no 1147 0.32958429212012 1605 16648742 SGTC_2544 sphondin 68.51 µM 0.438795520079933 0.343966334220969 no 1148 0.330404853352251 1624 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3099 9120367 49.47 µM 0.43830198876001 0.344140595391291 no 1149 0.330583692229851 1565 24824940 SGTC_3182 9108849 49.47 µM 0.436086251297503 0.344923358472451 no 1150 0.331387075999217 1567 17133045 SGTC_1030 k029-0042 36.7 µM 0.436024133880237 0.344945312545147 no 1151 0.331409609786099 1600 6080581 SGTC_1661 st013063 9.66 µM 0.435625651997279 0.345086159857143 no 1152 0.331554178052364 1586 721395 SGTC_1977 st070720 65.3 µM 0.435454488284674 0.345146665933512 no 1153 0.33161628354117 1556 682188 SGTC_818 4072-2707 53.5 µM 0.433743774284594 0.345751617662597 no 1154 0.33223725757755 1511 882871 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.432846598177053 0.346069039443464 no 1155 0.332563108913484 1553 688667 SGTC_543 3844-1095 191 µM 0.432313025387612 0.34625786933552 no 1156 0.332756960783226 1662 4230703 SGTC_659 k018-0002 107 µM 0.430072090096116 0.347051346878112 no 1157 0.333571600853462 1688 6797879 YHR007C ERG11 SGTC_337 1315-0038 354 µM 0.428871607779691 0.347476693778471 no 1158 0.334008331689149 1577 1626437 SGTC_3022 9087993 49.47 µM 0.428421302813663 0.347636292413444 no 1159 0.334172208931222 1639 17173644 SGTC_979 1426-2828 121 µM 0.426119413286531 0.348452557391985 no 1160 0.335010417455403 1670 747872 SGTC_124 0136-0217 7.121 µM 0.424141297729831 0.349154571290245 no 1161 0.335731384447199 1679 3976905 SGTC_1657 st012939 43.4 µM 0.422102680857118 0.349878596982152 no 1162 0.336475035618448 1679 24207257 SGTC_1273 0849-0096 14.1 µM 0.421860581871661 0.34996461606744 no 1163 0.336563391599129 1577 5286025 SGTC_2967 9089538 49.85 µM 0.421756540528619 0.350001584887925 no 1164 0.33660136510052 1768 728216 SGTC_1688 st021091 57.6 µM 0.421215924854747 0.350193703749426 no 1165 0.336798708382721 1700 3656366 SGTC_2233 sulbentine 40.3845 µM 0.420740513783013 0.350362682506535 no 1166 0.3369722868872 1577 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_489 paxilline 115 µM 0.420492404684284 0.35045088146357 no 1167 0.337062888401357 1557 105008 A toxic potassium channel blocker. SGTC_216 k038-0035 28.382 µM 0.419782920179552 0.350703136744278 no 1168 0.337322021617753 1632 4444231 YPR107C YTH1 SGTC_2933 9026794 32.47 µM 0.418857053699427 0.351032425052299 no 1169 0.337660302595735 1646 17586027 SGTC_339 3091-4833 71.4 µM 0.417823338485852 0.35140020241884 no 1170 0.338038142950792 1636 3240077 SGTC_185 k048-0037 25.491 µM 0.415717071578282 0.352150004858077 no 1171 0.338808523824363 1706 6827589 SGTC_2153 5569715 200 µM 0.415502622594604 0.352226378094621 no 1172 0.338886997840429 1629 2054701 SGTC_1125 tnp00248 1.32998 µM 0.41489028965213 0.352444485362046 no 1173 0.339111109310767 1796 24207736 SGTC_1018 4259-0013 28.1 µM 0.413918657260909 0.352790671303623 no 1174 0.339466839815499 1634 6801262 SGTC_2086 5274770 176.623 µM 0.413471633946575 0.352949983606216 no 1175 0.339630550438234 1609 689278 SGTC_57 miconazole 162.5 nM 0.413299062251749 0.353011492430132 no 1176 0.339693758415456 1544 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_465 cgp-37157 41 µM 0.410019091435825 0.354181283872668 no 1177 0.340895971411158 1691 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2649 anisomycin 9.56 µM 0.407757222452037 0.354988775630099 no 1178 0.341725961086447 1615 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_96 0929-0093 37.281 µM 0.407368669134758 0.355127555641998 no 1179 0.341868617363999 1582 6991579 SGTC_2063 5246145 200 µM 0.407090204893113 0.355227026842639 no 1180 0.341970868633631 1655 711240 SGTC_802 4112-3352 742 µM 0.406874513571783 0.355304081486058 no 1181 0.342050077834329 1714 704594 SGTC_2074 5212007 75.395 µM 0.406869675446484 0.355305809949921 no 1182 0.342051854638474 1734 758611 SGTC_611 3453-1652 23.7 µM 0.405794687138687 0.355689932957947 no 1183 0.342446731340678 1690 1560575 SGTC_314 1671-0008 2.74 µM 0.40566903385207 0.355734841923225 no 1184 0.342492898962014 1598 3913060 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.405086944214449 0.35594290910117 no 1185 0.342706801450608 1679 5393153 SGTC_2717 st081029 62.2815 µM 0.402691322238858 0.356799672180238 no 1186 0.343587659267304 1690 5292846 SGTC_1750 st081859 2.357 µM 0.402085135385247 0.357016581805553 no 1187 0.343810685988094 1654 5291695 SGTC_3097 9117246 49.47 µM 0.400119783730754 0.35772015398063 no 1188 0.344534146675232 1606 16423892 SGTC_767 0929-0023 86 µM 0.398777308662019 0.358201022068106 no 1189 0.345028649116846 1617 1204563 SGTC_1900 st060200 72.8 µM 0.398676977781221 0.358236969150912 no 1190 0.345065616771471 1609 688945 SGTC_2466 5983409 37.09 µM 0.396288505967289 0.359093093938405 no 1191 0.345946102776642 1619 2879657 SGTC_1001 4048-4355 44.4 µM 0.395553720591626 0.359356613334822 no 1192 0.346217141888462 1590 21824233 SGTC_280 3448-3607 3.04 µM 0.395222533962074 0.359475410174418 no 1193 0.34633933193966 1715 626179 SGTC_782 0083-0095 30.5 µM 0.393290606619835 0.360168664041574 no 1194 0.347052427630651 1628 3591729 An indicator and reagent. SGTC_2185 6113692 200 µM 0.392439531578498 0.360474210400573 no 1195 0.347366740932449 1643 874150 SGTC_3341 9147222 25.867 µM 0.391169827453315 0.360930215328258 no 1196 0.347835854616843 1657 1939759 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.389996960756086 0.361351617533309 no 1197 0.348269397157297 1771 6728940 SGTC_1787 fluconazole 80 µM 0.388389398766204 0.361929475799598 no 1198 0.348863944131782 1595 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2944 9067346 25.62 µM 0.387671248420952 0.362187725769101 no 1199 0.349129667719388 1676 6473075 SGTC_558 k064-0027 21.3 µM 0.387042564109256 0.362413854876648 no 1200 0.349362348624249 1712 5088526 SGTC_2047 4141938 200 µM 0.386382989548522 0.362651146391084 no 1201 0.349606523113042 1656 3807862 SGTC_1479 0549-0158 134 µM 0.385465819334727 0.362981199358634 no 1202 0.349946162928336 1653 5440202 SGTC_1081 sertraline 6 µM 0.385229874894821 0.363066122821088 no 1203 0.350033555591737 1742 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_201 4262-0159 12.803 µM 0.384245360565749 0.363420551602647 no 1204 0.350398300551065 1745 1341029 SGTC_3238 9133470 49.47 µM 0.382609542352419 0.364009710653268 no 1205 0.351004646963767 1739 3534688 SGTC_1673 st016611 27.3 µM 0.380020591973921 0.364942808184154 no 1206 0.351965064814735 1755 5226799 SGTC_2941 9056145 11.23 µM 0.37973889019777 0.365044386218276 no 1207 0.352069624298815 1652 2119517 SGTC_406 estrone 100 µM 0.37949568241536 0.365132091432334 no 1208 0.352159904932612 1778 5870 A steroid. SGTC_856 0433-0016 11.3 µM 0.379388136831796 0.365170876604209 no 1209 0.352199829352975 1649 3911780 SGTC_1393 3470-5649 58.2 µM 0.379181175236851 0.365245518984822 no 1210 0.352276664815446 1631 4108395 SGTC_763 3453-1109 128 µM 0.377913414910577 0.365702858365859 no 1211 0.35274745827454 1776 1560353 SGTC_2734 clemastine 41.6 µM 0.375437272093074 0.366596667010199 no 1212 0.353667644807997 1695 26987 Clemastine is a selective histamine H1 antagonist. SGTC_130 0136-0219 337.655 µM 0.375262328016017 0.366659843683614 no 1213 0.353732690117262 1773 234244 SGTC_1092 toremifene 6.32 µM 0.37502579872787 0.366745266057942 no 1214 0.353820639985309 1669 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1924 st058459 75.1 µM 0.374669556932867 0.366873934968564 no 1215 0.35395311787632 1666 688683 SGTC_2531 methyl deoxycholate 70.07 µM 0.372084848968312 0.367807937812381 no 1216 0.354914838279143 1611 16667744 Haematoxylin. SGTC_247 mechlorethamine 29.705 µM 0.371595492422198 0.367984858561144 no 1217 0.355097022842728 1690 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1205 4161-2785 76 µM 0.369808719241793 0.36863108166754 no 1218 0.355762509045792 1587 3498106 SGTC_3217 9129673 49.47 µM 0.369552421692728 0.368723807447491 no 1219 0.355858003547578 1683 17248312 SGTC_757 1066-0008 322 µM 0.366969967171459 0.369658538218723 no 1220 0.35682071011961 1732 6842497 SGTC_1704 st028805 70.8 µM 0.366611814765565 0.369788234042853 no 1221 0.356954297031836 1665 2876101 SGTC_1320 1313-0481 95.3 µM 0.366562744457331 0.369806004766508 no 1222 0.356972601084301 1804 6813365 YLR208W SEC13 SGTC_1483 3453-0561 55.9 µM 0.366220159120643 0.369930079173307 no 1223 0.357100400363195 1725 4546991 SGTC_865 0488-0499 301 µM 0.365869874972297 0.370056955865047 no 1224 0.357231088214151 1724 9634651 SGTC_2789 5281112 71.43 µM 0.364754849663998 0.370460924145004 no 1225 0.357647205535318 1617 765948 SGTC_1789 tunicamycin 25 nM 0.363995297755793 0.370736187979808 no 1226 0.357930760366839 1765 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1530 rhein 70.4 µM 0.363137132331273 0.371047269258571 no 1227 0.358251223784114 1701 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2737 bleomycin 30.5 nM 0.362609350664661 0.371238629717114 no 1228 0.358448362111145 1683 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3255 9139072 49.47 µM 0.361760695526605 0.371546397625004 no 1229 0.358765432993087 1685 17646060 SGTC_2623 humulene 100 µM 0.360370599470274 0.372050698447712 no 1230 0.359285004956274 1643 6187145 An anti-inflammatory. SGTC_1225 1216-0074 20.6 µM 0.359500536018284 0.372366452954522 no 1231 0.359610338444935 1662 4241466 SGTC_2064 5220758 200 µM 0.358798458094907 0.372621306452055 no 1232 0.35987293311585 1708 788518 SGTC_292 k038-0015 474 µM 0.3584142856531 0.372760784234857 no 1233 0.360016651212034 1729 46368540 SGTC_2390 9097792 176.6 µM 0.356052203166295 0.373618728756545 no 1234 0.360900735482892 1625 4497149 SGTC_515 4092-1064 102 µM 0.355663596575456 0.373759936766478 no 1235 0.36104625519213 1822 717353 SGTC_415 dibenzyl ketone 100 µM 0.355456233111314 0.373835293381531 no 1236 0.36112391385898 1796 7593 SGTC_949 1165-0505 146 µM 0.354714879922027 0.374104743172406 no 1237 0.361401601175794 1663 6244267 SGTC_1907 st060210 83.7 µM 0.354655513672963 0.374126322896097 no 1238 0.361423841043916 1782 688793 SGTC_2522 biochanin a 4.94 µM 0.354322246869906 0.374247473216997 no 1239 0.361548698615358 1752 5280373 A possible chelator. SGTC_2 0422-0095 29 µM 0.353266342706145 0.374631401171382 no 1240 0.361944387766356 1684 6790840 SGTC_452 diindolylmethane 8 µM 0.352355111733474 0.37496282573712 no 1241 0.362285980822588 1736 3071 Inhibits expression of several cancer promoting factors. SGTC_1476 4112-3294 3.34 µM 0.35225825965049 0.37499805732169 no 1242 0.362322294206023 1791 704369 SGTC_2924 9010168 62.78 µM 0.352244803911848 0.375002952156914 no 1243 0.362327339351937 1688 2993929 SGTC_312 4092-0653 6.84 µM 0.352160840885418 0.375033496098723 no 1244 0.362358821309089 1774 1148278 SGTC_927 2425-1185 123 µM 0.351008943156052 0.375452610753413 no 1245 0.362790819547687 1634 730375 SGTC_1745 st081495 74 µM 0.349982314970089 0.375826270391913 no 1246 0.363175984981678 1737 13842402 YBL026W LSM2 SGTC_1680 diphenhydramine 100 µM 0.349906106990433 0.375854012293397 no 1247 0.363204581848732 1699 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2597 laccaic acid a 100 µM 0.34903546509361 0.376170996552114 no 1248 0.363531342279888 1702 5491415 A textile dye. SGTC_1306 1185-0270 9.02 µM 0.348379632638721 0.376409827939551 no 1249 0.363777548216377 1786 1548076 SGTC_1440 4100-1550 40 µM 0.347816450834084 0.376614956952858 no 1250 0.363989017092335 1712 742806 SGTC_3083 9117465 49.47 µM 0.347526321959796 0.376720644867332 no 1251 0.364097973621274 1653 16420915 SGTC_3298 9116858 71.43 µM 0.347118178490542 0.376869338684858 no 1252 0.364251268570887 1797 2506942 SGTC_2585 alliin 100 µM 0.346480303175086 0.37710176441245 no 1253 0.364490892187708 1799 87310 A garlic compound which reacts with lipids. SGTC_670 4204-0025 119 µM 0.345377379194626 0.377503747213185 no 1254 0.364905340445666 1783 719039 SGTC_302 1094-0063 18.9 µM 0.345210261784817 0.377564668100805 no 1255 0.364968152322218 1710 5440289 SGTC_3064 1327-0027 10 µM 0.345015128753586 0.377635805642375 no 1256 0.365041498589678 1698 16000455 YPR107C YTH1 SGTC_1034 k072-0165 12.7 µM 0.344718821448216 0.377743835132657 no 1257 0.365152883510527 1847 5835461 SGTC_3053 9095903 49.47 µM 0.34451344855679 0.377818716821967 no 1258 0.365230091939476 1765 17174018 SGTC_1666 st014829 29 µM 0.344409061221231 0.377856779593876 no 1259 0.365269337685214 1679 3858230 SGTC_3331 9141060 1.957 µM 0.343497537084531 0.378189199146655 no 1260 0.365612096684507 1656 4906567 YPR165W RHO1 SGTC_1052 3253-3998 198 µM 0.343053714606136 0.378351087392205 no 1261 0.365779025428878 1677 5450317 SGTC_715 0868-0130 184 µM 0.342690396954324 0.378483626675294 no 1262 0.36591569393961 1862 2876258 SGTC_2319 6033012 152.6 µM 0.342310864897503 0.378622096285854 no 1263 0.366058479965167 1631 847246 SGTC_1420 4'-methoxyflavone 42 µM 0.342016405015635 0.378729538646747 no 1264 0.366169273259976 1835 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_677 0929-0063 136 µM 0.341950332187964 0.378753648551892 no 1265 0.366194135314779 1681 1539583 SGTC_867 0518-0118 155 µM 0.340262458379932 0.379369711668804 no 1266 0.366829443040878 1742 6848158 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.339015814081184 0.379824925688094 no 1267 0.3672989084864 1800 140250 A respiratory chain inhibitor. SGTC_1105 epirubicin 18.1 µM 0.338880434390559 0.379874369821557 no 1268 0.367349902176651 1671 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_663 1486-0733 13.9 µM 0.335753349386772 0.381017006446191 no 1269 0.368528435860384 1741 722445 YPR165W RHO1 SGTC_2093 5331342 194.4 µM 0.335421655784528 0.381138268343186 no 1270 0.368653517123972 1825 33839 SGTC_891 0929-0073 133 µM 0.334909835871579 0.381325404447745 no 1271 0.368846551106593 1796 5603632 SGTC_384 k007-0144 5.16 µM 0.334835080536865 0.381352739475285 no 1272 0.368874748012776 1735 6824886 SGTC_119 0121-0043 24.815 µM 0.334544699522693 0.381458925779088 no 1273 0.368984283294518 1729 1092378 SGTC_2172 5754775 163.918 µM 0.333359911449916 0.381892270561051 no 1274 0.369431310090773 1666 2263357 SGTC_1158 4092-0494 91.8 µM 0.332937972233562 0.382046633647609 no 1275 0.369590552657731 1806 1148199 SGTC_1422 4031-0024 15.5 µM 0.332042365739522 0.38237434623665 no 1276 0.369928634403146 1815 782427 SGTC_2851 9015922 71.43 µM 0.33093278893148 0.382780469843131 no 1277 0.370347627054722 1813 2996893 SGTC_615 k087-0205 167 µM 0.330671668563665 0.382876063006045 no 1278 0.370446252361269 1652 9642773 SGTC_136 0097-0015 404.482 µM 0.330394466078678 0.382977551454265 no 1279 0.370550961211269 1833 4861337 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.330382331680545 0.38298199424318 no 1280 0.370555545007197 1797 5377381 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.328898503214544 0.38352538688644 no 1281 0.371116202848395 1790 279621 SGTC_2145 5634607 200 µM 0.327700930876897 0.383964116886255 no 1282 0.371568899743614 1687 308662 SGTC_3351 9150312 21.596 µM 0.326821982686033 0.384286213783728 no 1283 0.371901265940079 1754 4904905 SGTC_120 rhodamine 6G 52.259 µM 0.323928015047316 0.385347292741215 no 1284 0.372996266807883 1696 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_162 k030-0015 37.8 µM 0.323589170882279 0.38547158694257 no 1285 0.373124543804365 1888 1809920 YMR134W ERG29 SGTC_830 4076-0286 57.8 µM 0.323490850420729 0.385507654878202 no 1286 0.373161767835717 1764 6866659 SGTC_1514 1189-1591 158 µM 0.323459427335748 0.385519182349887 no 1287 0.373173664834882 1813 767698 YMR146C TIF34 SGTC_1973 st070275 50.2 µM 0.32280877842328 0.385757893812843 no 1288 0.37342003221045 1825 17118334 SGTC_2424 5537928 59.2 µM 0.319791274572275 0.386865526418564 no 1289 0.37456328122693 1698 5382802 SGTC_1066 ketoconazole 628 nM 0.318796630431672 0.38723083211577 no 1290 0.374940366798233 1817 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_291 SEC14.278 35.5 µM 0.317798619723457 0.387597474663534 no 1291 0.375318848885571 1839 1068044 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.316598267915976 0.388038584729093 no 1292 0.375774225113629 1833 688751 SGTC_137 0438-0332 85.389 µM 0.315604454564905 0.388403904589234 no 1293 0.376151378063559 1767 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_166 k072-0058 166.424 µM 0.315365084818132 0.388491910248541 no 1294 0.376242236764131 1864 5846229 SGTC_2479 5617353 43.85 µM 0.314978370555702 0.38863410005617 no 1295 0.376389038205183 1814 2731746 SGTC_2835 9006588 71.43 µM 0.312241265221604 0.389640923664835 no 1296 0.37742858676411 1720 2345538 SGTC_1842 st055362 61.2 µM 0.31160613208496 0.389874658794501 no 1297 0.377669936699801 1816 676032 SGTC_842 0271-0008 11.1 µM 0.309876714427679 0.390511302844257 no 1298 0.378327355497404 1830 1221709 SGTC_2781 5567276 71.43 µM 0.309005765811165 0.390832033195249 no 1299 0.378658570420488 1815 2853274 SGTC_1871 st057448 67.3 µM 0.308940333058985 0.390856132073339 no 1300 0.378683457585892 1850 691747 SGTC_1321 1326-2144 215 µM 0.308490892539369 0.391021672308399 no 1301 0.378854414628801 1878 3513030 SGTC_2947 9072639 7.68 µM 0.308024906526338 0.391193327515299 no 1302 0.379031690233633 1696 16488146 SGTC_1203 3992-3522 103 µM 0.307550557265415 0.39136808526107 no 1303 0.379212173614741 1964 5322312 SGTC_2697 mebhydrolin 72.4 µM 0.306421123742736 0.391784274588183 no 1304 0.379642013484819 1893 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1976 st070609 63.5 µM 0.306063896297433 0.391915936519717 no 1305 0.379777998120322 1770 682556 SGTC_2269 7935389 174.42 µM 0.305817827174545 0.392006636461124 no 1306 0.379871677120162 1701 97605 SGTC_569 4130-2812 160 µM 0.305738245466097 0.392035971167198 no 1307 0.379901975542281 1890 743552 SGTC_2279 7948423 32.93 µM 0.305271183780316 0.392208147682915 no 1308 0.380079810556069 1936 1247112 SGTC_916 4466-0038 42 nM 0.304199754457513 0.3926031965457 no 1309 0.380487855947649 1932 5722064 YGL116W CDC20 SGTC_1714 st033236 13.627 µM 0.301029149468987 0.393772883600405 no 1310 0.381696133398281 1860 2916566 SGTC_2993 9054257 71.4286 µM 0.300876287561942 0.393829301128813 no 1311 0.381754416380002 1759 6470217 YGL055W OLE1 SGTC_1685 st024049 53.0905 µM 0.300279100036048 0.394049729541931 no 1312 0.381982136915597 1811 1941139 SGTC_1811 st050069 61.5 µM 0.298131112199621 0.394842855366087 no 1313 0.382801548282192 1916 3877702 SGTC_858 0438-0351 2.77 µM 0.296039704957949 0.395615508274989 no 1314 0.383599879738816 1763 2799119 SGTC_1122 capsaicin 818.572 nM 0.295117644081223 0.395956286499712 no 1315 0.383952005823379 1847 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1925 st057770 10.1 µM 0.294863932574183 0.39605006797863 no 1316 0.384048912605193 1666 5989122 SGTC_926 2268-1401 59.4 µM 0.292739184583299 0.396835691805196 no 1317 0.384860758143912 1772 2931578 SGTC_2505 galangin 7.89 µM 0.292635949665621 0.396873873527921 no 1318 0.384900216096198 1737 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2506 ethyl hematommate 54.16 µM 0.290975495734981 0.397488132644894 no 1319 0.385535030302741 1726 3940691 An allergen. SGTC_626 0214-0009 33 µM 0.290794671036567 0.397555041312232 no 1320 0.385604180606066 1873 3437874 SGTC_6 0844-0013 19.835 µM 0.289941180165809 0.397870890247203 no 1321 0.385930618436628 1860 1584900 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.289480628260392 0.398041353202573 no 1322 0.386106801012345 1857 616764 SGTC_3202 9113761 49.47 µM 0.288686515594053 0.398335321886649 no 1323 0.386410641282217 1942 4798415 SGTC_1402 3909-7673 35.9 µM 0.287575715675921 0.398746620257602 no 1324 0.386835768020199 1769 5328014 SGTC_1698 5-fluorocytosine 1.055 µM 0.286723142504888 0.399062380751206 no 1325 0.387162158050529 1916 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1931 st074438 57.1 µM 0.286023503099305 0.399321549786838 no 1326 0.387430060166665 1790 2787313 SGTC_1418 3966-3099 2.4 µM 0.285923789415573 0.399358490572003 no 1327 0.387468246356205 1874 740335 SGTC_1642 st009582 77.7 µM 0.283744703857635 0.400165997743044 no 1328 0.388303016666829 1934 6739311 SGTC_1752 st044819 83.042 µM 0.28344072968446 0.400278675948186 no 1329 0.388419505077622 1761 441209 YML126C ERG13 SGTC_2274 7947094 46.08 µM 0.28241556236216 0.400658749696084 no 1330 0.388812441717868 1781 2971028 SGTC_392 N-ethylmaleimide 8.33 µM 0.281990904419704 0.400816216288219 no 1331 0.388975242316554 1769 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1757 st041620 31.8375 µM 0.278620039063886 0.402066730100307 no 1332 0.390268216257122 1780 5289815 SGTC_2561 acetosyringone 100 µM 0.27842694603235 0.402138393689252 no 1333 0.390342318507318 1827 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_156 3474-0145 5.642 µM 0.276705416615443 0.402777458713769 no 1334 0.391003156179736 1957 2265471 SGTC_1254 0550-0035 264 µM 0.274732147880807 0.403510293783115 no 1335 0.391761015364491 1896 15121435 SGTC_3115 9123671 49.47 µM 0.274228579607845 0.40369736399715 no 1336 0.391954483151208 1882 3286988 SGTC_1382 3002-2117 298 µM 0.274146891289971 0.403727712409403 no 1337 0.391985869812811 1937 1497314 SGTC_3079 9117512 49.47 µM 0.273509952068648 0.403964364568913 no 1338 0.392230621625087 1868 7185044 SGTC_539 4859-0462 2.54 µM 0.273048634089638 0.404135787331539 no 1339 0.392407915423944 1962 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2253 7938677 135.83 µM 0.271714993092974 0.404631463087166 no 1340 0.392920586029399 1955 2301972 SGTC_642 0335-0876 158 µM 0.271388334254656 0.404752896093518 no 1341 0.393046186704376 1829 6812350 SGTC_1005 4092-0690 4.4 µM 0.270118471188542 0.405225045338963 no 1342 0.393534556088239 1782 1529343 SGTC_758 0868-0029 16 µM 0.269789702192237 0.405347307828826 no 1343 0.393661022812396 1947 762687 SGTC_1572 epiandrosterone 68.9 µM 0.269059222459152 0.405618991400151 no 1344 0.393942054705824 1871 441302 A steroid. SGTC_115 0527-0192 112.043 µM 0.266266009463175 0.40665827504604 no 1345 0.395017174478384 1818 4233931 SGTC_1471 k673-0312 37 µM 0.264498070828046 0.407316420540774 no 1346 0.395698075577076 1947 24099884 SGTC_2179 6298986 200 µM 0.263857274458493 0.407555032710839 no 1347 0.395944949620217 1977 738374 SGTC_2326 6164455 177.58 µM 0.262551328619142 0.408041431470895 no 1348 0.396448209142957 1821 2888790 SGTC_1076 itraconazole 331 nM 0.261940883459311 0.408268840072109 no 1349 0.396683509638914 1931 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1664 st014217 9.02 µM 0.261876237112296 0.408292924529831 no 1350 0.396708430245109 1952 3982782 SGTC_796 1234-0020 70.7 µM 0.261470392119888 0.408444132887642 no 1351 0.396864889604713 1798 46495034 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.260634144233838 0.408755742262854 no 1352 0.397187328091639 1805 2374 Ca(2+)-ATPase inhibitor. SGTC_3111 9122088 49.47 µM 0.259172866918949 0.409300393467267 no 1353 0.39775093254023 1952 16876704 SGTC_2236 dapsone 200 µM 0.257454880020857 0.409940950070907 no 1354 0.398413821039294 1970 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1575 cyproterone acetate 48 µM 0.255820226727683 0.4105506587295 no 1355 0.399044827406803 1789 9880 An androgen receptor antagonist and liver toxin. SGTC_997 3996-0078 137 µM 0.253812447147283 0.411299835380134 no 1356 0.399820228419308 1863 735687 SGTC_2630 antimycin a 100 µM 0.252270105560357 0.411875559846451 no 1357 0.400416146662526 1828 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2220 6782180 200 µM 0.251923060609349 0.412005130800717 no 1358 0.400550267267444 1953 833803 SGTC_647 0140-0236 81 µM 0.251475420947025 0.412172273455772 no 1359 0.400723281487621 1887 990837 SGTC_3100 9120536 49.47 µM 0.251424887755002 0.412191142874275 no 1360 0.400742813958711 1986 16421196 SGTC_2192 5915882 198.485 µM 0.250399523486474 0.412574064268226 no 1361 0.401139199041743 1878 2876149 SGTC_995 3931-2021 34.6 µM 0.250253469202735 0.412628614893255 no 1362 0.401195668964037 1878 730143 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.250083966616884 0.412691925470436 no 1363 0.401261207444257 1978 77254 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.249958937620268 0.412738626260543 no 1364 0.401309551911611 1858 390807 SGTC_533 1222-0222 6.71 µM 0.246705052791785 0.413954448752325 no 1365 0.402568247927768 1977 3982874 SGTC_1006 4099-6547 255 µM 0.246602978552804 0.413992602465994 no 1366 0.402607749589743 1933 3146833 SGTC_1963 st076565 50.3 µM 0.243521504665093 0.415144788570795 no 1367 0.403800714060536 1834 4914280 SGTC_2981 9013952 38.96 µM 0.242984699478946 0.415345578996617 no 1368 0.404008625177587 1750 2996344 SGTC_2961 9083290 32.55 µM 0.240154921173353 0.416404413666756 no 1369 0.405105079397967 1924 17741490 SGTC_1474 0330-0125 5.35 µM 0.23962628133451 0.416602285431288 no 1370 0.405309994359559 1899 X1474 SGTC_2923 7992654 58.14 µM 0.238860518119755 0.416888950782063 no 1371 0.405606870716177 1864 2985126 SGTC_3134 9127454 49.47 µM 0.237556261028015 0.417377304311689 no 1372 0.406112639016948 1977 24262820 SGTC_2354 9060492 162 µM 0.236936824865483 0.417609284749176 no 1373 0.406352900571278 1980 6471895 SGTC_283 0987-0079 11.7 µM 0.236115573313112 0.41791688977021 no 1374 0.406671494894326 1977 411556 SGTC_1430 4049-0248 69.1 µM 0.236020904892987 0.417952351664323 no 1375 0.406708224305609 1993 22774488 SGTC_1086 cerivastatin 2.18 µM 0.23550345649836 0.418146194716108 no 1376 0.40690899819631 1989 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2796 7949634 45.45 µM 0.234982660555822 0.418341311881787 no 1377 0.407111095666732 1857 2971588 SGTC_790 1575-0012 79.1 µM 0.2342656557988 0.418609971913191 no 1378 0.407389373405131 2009 378741 YLR208W SEC13 SGTC_1050 3232-1156 69.3 µM 0.233043124745968 0.419068138979355 no 1379 0.407863959404157 1853 700529 SGTC_2690 usnic acid 100 µM 0.232824240307793 0.419150181744397 no 1380 0.407948944536337 1992 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1433 4060-0023 7.6 µM 0.231997164795357 0.419460219788019 no 1381 0.408270107950579 1969 3840627 SGTC_733 4069-0007 56.1 µM 0.230685571304962 0.419951987002868 no 1382 0.408779541828831 1934 5717425 YNL287W SEC21 SGTC_2460 5552655 174.22 µM 0.230395172646052 0.420060885641461 no 1383 0.408892355970068 1860 5401989 SGTC_2518 prenyletin 46.28 µM 0.230330488514202 0.420085142833441 no 1384 0.408917485505476 2010 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.229947778279627 0.420228669181538 no 1385 0.409066174610974 1970 16623 A steroid. SGTC_3023 9089636 49.47 µM 0.229164307041688 0.42052252445564 no 1386 0.409370606629336 2056 17249241 SGTC_1847 st056231 15 µM 0.227477563309038 0.421155318806687 no 1387 0.410026206922195 1872 5393180 SGTC_2304 7443016 91.4 µM 0.226956456656661 0.421350857078863 no 1388 0.410228800602653 1897 939854 SGTC_2046 4110841 106 µM 0.225226509598859 0.422000135310923 no 1389 0.410901533759956 2036 44119630 YMR134W ERG29 SGTC_837 0091-0265 12.5 µM 0.224853034841691 0.422140334562735 no 1390 0.411046803229661 1875 759367 SGTC_1227 3909-8010 46.6 µM 0.224417000806428 0.42230403051937 no 1391 0.411216421648056 1920 15982272 SGTC_2658 polymyxin b sulfate 77.05 µM 0.224388144449982 0.422314864250429 no 1392 0.411227647434641 1912 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_50 0929-0078 56.389 µM 0.223709222124724 0.422569773450898 no 1393 0.411491784793762 1967 1377751 SGTC_3018 9082602 49.47 µM 0.223595556316222 0.422612453758953 no 1394 0.411536010840553 1919 17332089 SGTC_2023 5144124 124 µM 0.22304421933072 0.422819487843957 no 1395 0.411750545601246 1888 2830192 SGTC_746 1095-0025 46.6 µM 0.222821952950263 0.422902957743776 no 1396 0.411837040761272 1961 6749286 SGTC_1193 1488-0126 41.5 µM 0.222791456286291 0.422914410728794 no 1397 0.411848908899537 1887 1384710 SGTC_556 4058-0063 51.5 µM 0.22145214512911 0.423417451529603 no 1398 0.412370197095228 1896 6615692 SGTC_801 0866-0028 10.1 µM 0.221032082905979 0.423575251257998 no 1399 0.412533726083662 1894 6849771 SGTC_722 3534-0461 190 µM 0.220880907631472 0.423632044457832 no 1400 0.412592581890546 1862 658262 SGTC_132 0417-1715 25.805 µM 0.218468097916487 0.424538697533704 no 1401 0.413532206079736 2059 6769098 SGTC_1350 1495-0454 146 µM 0.218458928234367 0.424542143957992 no 1402 0.413535777991405 1998 1069057 SGTC_3343 9148379 18.9835 µM 0.217870312392296 0.424763387234473 no 1403 0.413765079393046 2033 1955036 SGTC_2240 6690706 185.951 µM 0.217831728753785 0.424777890510948 no 1404 0.41378011107715 1802 805876 SGTC_1596 piperlongumine 63 µM 0.21730539857473 0.424975743913129 no 1405 0.413985175081857 2040 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2720 fluspirilene 36.88 µM 0.21666972172354 0.42521472714601 no 1406 0.414232873014123 1989 3396 An atypical antipsychotic. SGTC_482 fipronil 114 µM 0.215569805649187 0.425628306365216 no 1407 0.414661547005187 2028 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2263 7948595 193.29 µM 0.215304637762773 0.42572802434827 no 1408 0.41476490700361 1878 2971371 SGTC_2302 7771753 200 µM 0.213300356512666 0.426481899608745 no 1409 0.415546347747699 1844 2203047 SGTC_1800 st050079 29.0735 µM 0.212388274798393 0.42682505228038 no 1410 0.415902066240467 1946 3645560 SGTC_1877 wortmannin 25 µM 0.211785910068588 0.427051710459874 no 1411 0.416137030663252 2033 312145 A covalent inhibitor of PI 3-kinase. SGTC_1167 k781-0610 148 µM 0.210527495155114 0.427525305250511 no 1412 0.416627997228392 1918 4525169 SGTC_2608 thymoquinone 42.66 µM 0.210153119731255 0.427666218757098 no 1413 0.416774083747058 2044 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2919 7978188 46.38 µM 0.209954013710666 0.42774116527688 no 1414 0.416851782380096 2051 2980291 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.209829000626855 0.427788223426412 no 1415 0.416900568831839 1949 5355888 SGTC_794 k038-0031 316 µM 0.209633170370096 0.427861941051198 no 1416 0.416976994311823 1921 6624242 SGTC_1923 st058458 19.1 µM 0.206719688492165 0.428958977535652 no 1417 0.41811439015715 2058 3534982 SGTC_1987 st072290 61.9 µM 0.206576480343504 0.429012915063269 no 1418 0.418170315011755 1942 54697379 SGTC_3014 9081533 49.47 µM 0.206531040530477 0.429030029667944 no 1419 0.418188060262179 2058 21367265 SGTC_1179 1021-1431 9.29 µM 0.205813515171185 0.429300298510806 no 1420 0.418468291814264 1964 2840958 SGTC_2453 5731132 22.18 µM 0.205112521941486 0.429564372239349 no 1421 0.418742106664829 2048 1362040 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.204122303857763 0.42993745460622 no 1422 0.419128962649167 1914 75037 A free radical scavenger. SGTC_692 k241-0027 77.8 µM 0.202447266366859 0.430568697199192 no 1423 0.419783540044493 2031 3600480 SGTC_1459 k035-0031 35.7 µM 0.202356460615858 0.430602922687247 no 1424 0.419819031814184 1855 3877128 YMR208W ERG12 SGTC_1942 st076330 65.2 µM 0.202081043899396 0.430706732862829 no 1425 0.419926683462465 2000 24208414 SGTC_1611 st001856 99.4 µM 0.201695519500851 0.43085205290963 no 1426 0.420077382768904 1891 647478 SGTC_3107 9121808 49.47 µM 0.201570136355584 0.430899317007208 no 1427 0.420126396857489 2069 662681 SGTC_698 k064-0052 127 µM 0.201437319733144 0.430949384288046 no 1428 0.420178318151127 2006 5088751 SGTC_1047 2043-3044 82 µM 0.201415876998455 0.430957467562726 no 1429 0.420186700775264 1916 669592 SGTC_2693 st077581 40.7 µM 0.201192425376572 0.43104170391386 no 1430 0.42027405703685 2090 25238761 SGTC_513 4245-1575 41.7 µM 0.20117072194878 0.431049885796411 no 1431 0.420282541992441 2015 719745 SGTC_977 1348-1378 135 µM 0.200547267025302 0.431284932025692 no 1432 0.420526297511029 2001 X977 SGTC_1188 1403-0014 4.57 µM 0.199298944775492 0.431755630033483 no 1433 0.421014452281859 1931 9614867 SGTC_2226 7298446 200 µM 0.196298114238636 0.432887531942269 no 1434 0.422188418649232 2058 3283010 SGTC_2622 2-methoxyxanthone 59.94 µM 0.195400002934062 0.433226403651032 no 1435 0.422539907156832 2048 71034 A hepatoprotective. SGTC_2175 5807670 165.306 µM 0.19436318384307 0.433617673065886 no 1436 0.422945757607969 2060 241186 SGTC_2161 5662504 8.5105 µM 0.193346447345796 0.434001427004249 no 1437 0.423343826404119 1946 2859334 SGTC_472 calcifediol 10 µM 0.193325468972798 0.434009345673987 no 1438 0.423352040602117 1973 5283731 A vitamin D metabolite. SGTC_1910 st062352 60.4 µM 0.191269396964349 0.434785575577501 no 1439 0.424157268061164 1968 2245730 SGTC_2238 6671620 73.2395 µM 0.190137313785261 0.435213079039102 no 1440 0.424600765606192 2075 729941 SGTC_2969 9091408 28.7 µM 0.190016976347361 0.435258525984628 no 1441 0.424647913841667 1836 4286311 SGTC_237 nikkomycin 200 µM 0.189930059913869 0.435291351599837 no 1442 0.424681968390628 2073 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2768 sulfasalazine 50.2 µM 0.189704574073853 0.435376512619146 no 1443 0.424770318154055 2077 5384001 An antioxidant and salicylic acid derivative. SGTC_2710 st078562 53.7235 µM 0.189519578783443 0.435446383491021 no 1444 0.424842805750461 2030 17250908 SGTC_2620 irigenin 100 µM 0.18736965688552 0.436258534749736 no 1445 0.425685405782833 2037 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1048 3161-0300 24.5 µM 0.186643097809781 0.436533059555545 no 1446 0.425970236647908 2027 2165101 SGTC_919 tnp00227 403.569 nM 0.184479817916627 0.437350618883776 no 1447 0.426818529201907 1952 1269246 A methoxyflavone. YNL221C POP1 SGTC_3171 9103192 49.47 µM 0.184152644555611 0.437474289524868 no 1448 0.426946854112583 2110 13018434 SGTC_1352 1496-0991 99 µM 0.183001623767391 0.437909420724732 no 1449 0.427398372275921 1955 3000039 SGTC_1355 1499-0035 1.68 µM 0.182876359229247 0.437956780194678 no 1450 0.42744751633348 1961 1548538 SGTC_368 fentichlor 4.58 µM 0.181750430568625 0.438382506203012 no 1451 0.427889293576062 1941 7329 A pesticide. SGTC_1873 rapamycin 2 nM 0.178024696237986 0.439791753089318 no 1452 0.429351790369417 1969 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_301 4119-0100 24.5 µM 0.177797574081298 0.439877686167489 no 1453 0.429440976298963 1968 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_980 1473-0395 201 µM 0.177355520097868 0.440044948154789 no 1454 0.429614571603272 1937 768876 SGTC_822 1487-0950 154 µM 0.176576758970505 0.440339637576624 no 1455 0.4299204254289 2108 1958375 SGTC_1378 2093-0007 380 nM 0.176206211731385 0.44047986722115 no 1456 0.430065970443988 1989 3618014 SGTC_2016 5121758 140 µM 0.175947550698182 0.440577759151537 no 1457 0.430167573984538 2090 2795203 SGTC_2686 alizarin 95.37 µM 0.172872355639471 0.44174186309603 no 1458 0.431375880737489 1951 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2694 st077685 81.9 µM 0.172369707842435 0.441932186727625 no 1459 0.431573442679661 1982 2838096 SGTC_1762 st045503 25.4615 µM 0.17093120736353 0.4424769375447 no 1460 0.432138928917636 1970 4645554 SGTC_2403 6032726 181.2 µM 0.170470027069881 0.442651606612941 no 1461 0.432320252134429 1986 2881040 SGTC_1337 1486-1011 40.3 µM 0.169835277705967 0.442892032073077 no 1462 0.432569841169722 2120 X1337 SGTC_2951 9072950 58.06 µM 0.167967572611071 0.44359958863108 no 1463 0.433304394950668 2135 16488155 SGTC_2759 disulfiram 3.38 µM 0.167449605794398 0.443795845788106 no 1464 0.433508148169555 2009 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_933 2914-0560 114 µM 0.167408523327053 0.44381141248839 no 1465 0.433524309585444 2162 463887 SGTC_2382 9035899 200 µM 0.167231220614122 0.443878595868883 no 1466 0.433594059905553 1972 6462679 SGTC_542 3381-0244 89.3 µM 0.166542827298655 0.44413945649983 no 1467 0.43386489121759 2112 1112843 SGTC_2645 abamectin 100 µM 0.162177426596799 0.445794245690605 no 1468 0.435583067714886 2091 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_321 4534-3890 65.3 µM 0.160431422156204 0.446456368399559 no 1469 0.436270619440597 2123 699746 SGTC_485 niflumic acid 177 µM 0.159688228020807 0.4467382491274 no 1470 0.436563337288032 2083 4488 A COX2 inhibitor. SGTC_186 3455-3465 67.277 µM 0.159607237786565 0.446768968956264 no 1471 0.436595238574902 2079 755278 SGTC_2291 7917025 104.35 µM 0.159527986862625 0.446799029368939 no 1472 0.436626455163093 1979 2964612 SGTC_1207 2099-0101 141 µM 0.158022654102186 0.447370070142019 no 1473 0.437219473801725 2119 5837381 SGTC_813 k007-0158 173 µM 0.15768631272906 0.447497674586479 no 1474 0.437351993205577 2099 6523916 SGTC_1755 st041960 45.185 µM 0.156255534005589 0.448040557833427 no 1475 0.437915802230075 2026 2257073 SGTC_2356 9061756 188.97 µM 0.155860506722791 0.448190461018767 no 1476 0.438071487931499 2141 20104043 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.155706018203791 0.448249087644208 no 1477 0.438132376596724 1988 6857784 SGTC_1957 st077035 62.4 µM 0.152994211000097 0.449278370370871 no 1478 0.439201420249342 2158 705593 SGTC_2334 9017922 200 µM 0.152818960636452 0.449344899518584 no 1479 0.439270522469125 2106 3163164 SGTC_90 0870-0863 4.608 µM 0.152068591400306 0.449629773356421 no 1480 0.439566418247341 2012 1738164 SGTC_2654 protoveratrine a 100 µM 0.15190943918475 0.449690198022143 no 1481 0.439629181654192 2112 5702278 A heart drug and vasodilator. SGTC_2876 9059903 25.97 µM 0.150154848880399 0.450356433105914 no 1482 0.440321223656682 2145 6916095 SGTC_365 0121-0052 13.6 µM 0.150085796118531 0.45038265598829 no 1483 0.440348463052147 2076 3101739 SGTC_2823 7987624 58.44 µM 0.149949892409492 0.450434266243414 no 1484 0.44040207411281 2053 2239440 SGTC_2484 5809818 12.04 µM 0.149807451356368 0.450488359994078 no 1485 0.440458265186304 2051 2870548 SGTC_58 0957-0393 9 µM 0.148574772776841 0.450956523236272 no 1486 0.440944590222186 2034 6997992 SGTC_662 k832-1615 104 µM 0.14503829823342 0.452300029552444 no 1487 0.442340316929408 2075 5878478 SGTC_331 k048-0133 24.5 µM 0.145004168412137 0.452312998154621 no 1488 0.442353790329986 2027 6813582 SGTC_343 4130-2827 29.8 µM 0.140530011523146 0.454013517442448 no 1489 0.444120620997063 2021 1118244 SGTC_2862 9027634 71.43 µM 0.14033914428174 0.454086080461867 no 1490 0.444196018838404 1974 5012562 SGTC_2214 7179297 48.276 µM 0.139227721024557 0.454508646550399 no 1491 0.444635101811047 2095 769744 SGTC_126 0417-1624 672.48 µM 0.137682819930942 0.455096107497902 no 1492 0.445245548892117 2188 41912 YDL195W SEC31 SGTC_2677 mitomycin C 100 µM 0.137223724111204 0.455270701327857 no 1493 0.445426979581311 2107 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1768 st044301 37.178 µM 0.137082731157116 0.455324322588684 no 1494 0.445482701070798 2049 3931349 SGTC_3275 9138069 49.47 µM 0.134010721003992 0.45649284418716 no 1495 0.446697048386411 2076 17617007 SGTC_3310 9130229 44.1445 µM 0.133601820690827 0.45664840900807 no 1496 0.446858722197587 2140 7761258 SGTC_22 0964-0034 14.468 µM 0.132563329448819 0.457043529503009 no 1497 0.447269367629766 2074 138402 SGTC_421 streptovitacin 30 mM 0.131979000309589 0.457265871132093 no 1498 0.447500450881088 2038 91467 include heat shock SGTC_3188 9110789 49.47 µM 0.131414826342494 0.457480556260238 no 1499 0.447723580325553 2165 849217 SGTC_3355 9151058 44.0485 µM 0.131364169899364 0.457499833165283 no 1500 0.44774361563718 2185 17015728 SGTC_2966 9084041 48.03 µM 0.130676860403943 0.457761393170132 no 1501 0.448015469037973 1939 17741380 SGTC_2412 st077135 33.4 µM 0.130531014810993 0.457816897995885 no 1502 0.448073158888148 2127 13258915 SGTC_2905 7799065 20.05 µM 0.130305243337291 0.457902822038097 no 1503 0.448162465929017 2167 1296806 SGTC_438 sphingosine 6.67 µM 0.130164491216329 0.457956390435494 no 1504 0.448218143714419 1936 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2575 plumbagin 510 nM 0.126109655919638 0.45949993123681 no 1505 0.449822562089159 2039 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2882 9058044 58.44 µM 0.125983026055028 0.459548144964549 no 1506 0.449872680378861 2009 18076804 SGTC_780 0109-0199 192 µM 0.125255018360873 0.459825342003671 no 1507 0.450160830901809 2193 610414 SGTC_3199 9111318 49.47 µM 0.124684666380654 0.460042523523635 no 1508 0.450386598558363 2137 8548020 SGTC_1456 k015-0012 13 µM 0.123563026062708 0.460469662130002 no 1509 0.450830634501884 2211 2989616 SGTC_1682 st012968 530 nM 0.122203035351667 0.460987629529098 no 1510 0.451369111305564 2003 24207270 SGTC_270 tamoxifen 5.46 µM 0.122115779017358 0.461020864331392 no 1511 0.451403662777904 2210 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_555 4296-0685 37 µM 0.12147119061691 0.461266388084396 no 1512 0.451658916132034 2196 2908540 YHR072W ERG7 SGTC_2872 9044037 25.97 µM 0.120048765267865 0.461808242075672 no 1513 0.452222259078313 2115 6465195 SGTC_1198 1612-1005 86.7 µM 0.120012824645256 0.461821934099688 no 1514 0.452236494395116 2173 6998509 SGTC_275 trichlorophene 5.69 µM 0.118507212545134 0.462395556074571 no 1515 0.452832890292089 2110 62616 SGTC_1051 3253-3903 78 µM 0.118057632223566 0.462566856548231 no 1516 0.453010996602523 2194 5509239 SGTC_2735 sertaconazole 140 nM 0.117992907008303 0.462591518920814 no 1517 0.453036639005203 2221 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_455 paf C-16 10 µM 0.117789531618197 0.462669012370123 no 1518 0.453117212180304 2148 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_947 3447-0010 211 µM 0.116415301695065 0.463192681132937 no 1519 0.45366170442457 2196 748350 SGTC_353 1988-1175 58.3 µM 0.116063886469471 0.463326602900514 no 1520 0.453800954879152 2064 2788357 SGTC_3308 9128332 17.569 µM 0.112573218745405 0.46465709403826 no 1521 0.455184459199294 2193 17332805 YDL196W YDL196W SGTC_3172 9105863 49.47 µM 0.112433161830066 0.464710486006923 no 1522 0.455239981339299 2213 2348785 SGTC_2250 alverine citrate 130 µM 0.112218862716957 0.464792181535603 no 1523 0.455324936675532 2114 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_426 0988-0037 14.6 µM 0.11178605875096 0.464957180435409 no 1524 0.455496520869755 2244 5383008 SGTC_1335 1486-0900 202 µM 0.111722609859623 0.464981369716375 no 1525 0.45552167574368 2223 X1335 SGTC_1796 st049173 110.4 µM 0.110923312773755 0.46528610511436 no 1526 0.455838579379089 2205 94134 SGTC_2925 9010536 32.5 µM 0.110624924114187 0.465399872282421 no 1527 0.455956891103551 2119 2994177 SGTC_2936 9038235 15.59 µM 0.109779134057191 0.465722363480558 no 1528 0.456292269810883 2207 4749415 SGTC_47 0149-0135 24.25 µM 0.109670079485958 0.465763946528928 no 1529 0.456335515179001 2210 5239155 SGTC_221 trifluoperazine 10.304 µM 0.108050301036419 0.466381619839677 no 1530 0.456977895640674 2213 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2581 avocatin a 64 µM 0.107981383403303 0.466407902143226 no 1531 0.457005229872346 2129 6710728 A skin care supplement. SGTC_1220 1838-0075 193 µM 0.107888844552814 0.466443192821769 no 1532 0.457041933112313 2146 5529645 SGTC_2492 derrusnin 100 µM 0.107307534188472 0.46666488775827 no 1533 0.457272503819673 2118 1715307 Part of coumarin class of compounds. SGTC_397 arbidol 50 µM 0.106872693425506 0.466830730196864 no 1534 0.457444988291616 2204 131410 A RNA synthesis inhibitor. SGTC_3141 9094609 49.47 µM 0.106686381161458 0.466901788961092 no 1535 0.45751889359839 2024 25236309 YDL196W YDL196W SGTC_2104 5389443 200 µM 0.106498706366842 0.46697336845564 no 1536 0.457593340871345 2187 2244536 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.105351387346842 0.467410981072967 no 1537 0.458048494299801 2240 4000243 SGTC_2296 7971656 126.45 µM 0.105006935812655 0.467542370149052 no 1538 0.458185152583443 2135 666570 SGTC_1717 st033143 58.0435 µM 0.10478403631501 0.467627395778535 no 1539 0.45827358874204 2206 674616 SGTC_2135 5326629 150.42 µM 0.104727148898892 0.467649095877383 no 1540 0.45829615935522 2123 5020077 SGTC_1677 st019204 53.9 µM 0.104709629749067 0.467655778697777 no 1541 0.458303110268476 2034 3945625 SGTC_2432 5630864 12.22 µM 0.104024617080306 0.467917089409626 no 1542 0.458574906471496 2128 5714970 SGTC_1294 1000-1494 117 µM 0.101437362542597 0.468904169134715 no 1543 0.459601639199937 2106 712797 YDL207W GLE1 SGTC_1619 st003326 88.7 µM 0.101396247221735 0.468919856858136 no 1544 0.459617957702734 2248 2849032 SGTC_1761 st044296 37 µM 0.100018391213736 0.469445611360215 no 1545 0.460164862290541 2211 1826700 SGTC_765 1319-0117 244 µM 0.0981305283305956 0.470166057730073 no 1546 0.460914323202536 2248 3487746 YGL099W LSG1 SGTC_3307 9126885 69.2785 µM 0.097109626868679 0.470555695060411 no 1547 0.461319667930887 2155 24824909 SGTC_2627 acetyl isogambogic acid 100 µM 0.0969173102186849 0.470629097814595 no 1548 0.461396030977112 2124 6857789 A caspase activator and apoptosis inducer. SGTC_75 0159-0059 199.013 µM 0.0963998996854377 0.470826586225506 no 1549 0.461601485896679 2222 5377270 SGTC_2515 chrysin 20.77 µM 0.0950438182546167 0.471344217585323 no 1550 0.462140011247735 2214 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1684 st024538 14.6195 µM 0.0934296238335917 0.471960436584618 no 1551 0.462781128512213 2136 6732859 SGTC_3000 9075062 71.4286 µM 0.0920755262553213 0.472477415404664 no 1552 0.463319016527521 2132 17057871 SGTC_1917 st066507 28.5 µM 0.0884194488435091 0.473873492704685 no 1553 0.46477165194664 2140 3156428 SGTC_435 c-PAF 6.7 µM 0.087390904230693 0.474266302212651 no 1554 0.465180399545466 2257 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2566 crystal violet carbinol 226 nM 0.0872966550290393 0.47430229800231 no 1555 0.46521785638612 2021 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1147 3809-1045 12.3 µM 0.0872822216072407 0.474307810453901 no 1556 0.465223592593286 2116 325925 SGTC_1062 mesoridazine 14.2 µM 0.0853030399465555 0.475063751011715 no 1557 0.466010237408192 2252 4078 A neuroleptic. SGTC_2286 7945697 125 µM 0.0850030449718964 0.47517834080066 no 1558 0.466129484967928 2172 1245733 SGTC_2779 methotrexate 400 µM 0.0844344686361112 0.475395526872037 no 1559 0.46635550155699 2256 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_688 0527-0193 473 µM 0.0842075474084063 0.475482208799282 no 1560 0.466445708770044 2181 4007154 SGTC_1696 st025591 34.7925 µM 0.0841128611097205 0.475518378481829 no 1561 0.466483349597764 2265 2787147 SGTC_1245 0418-0076 17.2 µM 0.083607177906897 0.475711550291397 no 1562 0.466684379888447 2180 6790114 SGTC_1857 st056007 79.3 µM 0.0827804341099533 0.476027380048267 no 1563 0.467013063520271 2256 619834 SGTC_2849 9019321 12.99 µM 0.0818522324908635 0.476381986303236 no 1564 0.467382109931904 2208 16489627 SGTC_2148 5546263 113.568 µM 0.0811853431632523 0.476636773469454 no 1565 0.467647277749243 2176 792097 SGTC_1015 4130-4525 82 µM 0.0807468513980092 0.476804305839621 no 1566 0.467821638204196 2083 1363237 SGTC_727 3032-0951 202 µM 0.079995938896624 0.477091212754218 no 1567 0.468120242955936 2186 3652836 SGTC_2997 9067075 71.4286 µM 0.0796136463589964 0.47723728277534 no 1568 0.468272270722529 2206 27209819 SGTC_1719 st032227 49.2 µM 0.0795405266893037 0.477265221393208 no 1569 0.468301349034989 2209 3125804 SGTC_3174 9107204 49.47 µM 0.0790250231523852 0.477462195581906 no 1570 0.46850635985149 2233 3938802 SGTC_2157 5649910 96.377 µM 0.0789290912683533 0.477498851817355 no 1571 0.468544511965791 2215 2858091 SGTC_3279 9140807 49.47 µM 0.0789140874077586 0.477504584913338 no 1572 0.468550479027911 2241 45595718 SGTC_3125 9127534 49.47 µM 0.0789106170124331 0.477505910980007 no 1573 0.468551859211329 2285 1639235 SGTC_1635 st007035 42.4 µM 0.0784474611298024 0.477682888890583 no 1574 0.468736060650943 2262 3716403 SGTC_1416 3966-0321 25.3 µM 0.0784328062774686 0.477688488773037 no 1575 0.468741889132642 2226 582530 YLR208W SEC13 SGTC_2290 7904846 200 µM 0.0779125962775804 0.477887273208689 no 1576 0.468948789745318 2193 2962154 SGTC_803 4488-1585 147 µM 0.0777135438473501 0.477963337266441 no 1577 0.4690279601291 2248 747204 SGTC_1123 mangostin 811.285 nM 0.0776463060383736 0.477989031083441 no 1578 0.469054703325589 2124 5281650 An antioxidant. SGTC_1784 st039334 36.3 µM 0.0774898002397393 0.478048837540873 no 1579 0.469116952553088 2276 3496984 SGTC_3276 9139060 49.47 µM 0.0768553397411002 0.478291292615847 no 1580 0.469369313067189 2298 4870619 SGTC_962 1254-0300 21.5 µM 0.0764579412806581 0.478443160027086 no 1581 0.46952738699103 2220 7340576 SGTC_1828 st055811 49 µM 0.0761684531011787 0.4785537910646 no 1582 0.469642540267139 2283 5877589 SGTC_905 2-aminofluorene 215 µM 0.0753687273745288 0.478859423459065 no 1583 0.469960670179204 2275 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1127 asiatic acid 681.4 nM 0.0752812298221355 0.478892863289138 no 1584 0.46999547776552 2200 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1748 st037455 53.6035 µM 0.0735611401031227 0.479550277356146 no 1585 0.470679796515952 2231 580690 SGTC_3210 9128157 49.47 µM 0.0719372057249163 0.48017099217482 no 1586 0.471325940425268 2036 17590849 SGTC_1104 tacrolimus 29.8 µM 0.0717337891513624 0.480248747308728 no 1587 0.471406882782206 2275 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2792 7535235 81.82 µM 0.0715847908969342 0.480305701744915 no 1588 0.471466172063133 2195 1281891 SGTC_1608 st001473 40.5 µM 0.0699884870739637 0.480915912302875 no 1589 0.472101411575233 2128 7292267 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.067052537735241 0.482038337735654 no 1590 0.473269939104735 2181 688803 SGTC_1297 1068-0111 14.1 µM 0.0670360295447126 0.482044649295266 no 1591 0.473276510135121 2238 767057 SGTC_12 0849-0099 9.267 µM 0.0665050211787733 0.48224767157284 no 1592 0.473487880119788 2294 6071388 SGTC_3061 glucosamine 200 µM 0.0654295700914523 0.482658866580554 no 1593 0.473915990493751 2279 91431 and experimental redox chemotherapeutic SGTC_914 3820-6779 408 µM 0.0652039087289875 0.482745149778898 no 1594 0.474005824519177 2283 2893481 SGTC_2756 carbadox 75.1 µM 0.0648209162255469 0.482891591485638 no 1595 0.474158293865717 2239 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_815 1582-0027 36.9 µM 0.0646253218209928 0.482966380207759 no 1596 0.474236161475547 2245 3128206 SGTC_850 0388-0143 75.9 µM 0.0645667763753705 0.482988766133849 no 1597 0.474259469051194 2194 67273 SGTC_102 gallobenzophenone 83.616 µM 0.0630818702295675 0.483556565001315 no 1598 0.474850655501814 2299 70837 SGTC_2477 5967686 25.23 µM 0.0616378884582901 0.484108747186771 no 1599 0.475425601832545 2275 776118 SGTC_2939 9044578 71.43 µM 0.0612637849950984 0.484251810285969 no 1600 0.475574565995067 2293 2653634 SGTC_944 3370-0224 231 µM 0.0605727771200392 0.4845160679768 no 1601 0.475849727206364 2260 4580514 SGTC_772 k072-0172 35.3 µM 0.0599523996427965 0.484753320736573 no 1602 0.47609677301712 2145 5861980 SGTC_3222 9128301 49.47 µM 0.0599040165457935 0.484771824252815 no 1603 0.476116040450651 2268 4911358 SGTC_643 k048-0106 28.4 µM 0.0594665492181657 0.484939129698187 no 1604 0.47629025408255 2264 6763920 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.0590702904045195 0.485090677607266 no 1605 0.476448061064826 2306 756377 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.0590468692026622 0.485099635038223 no 1606 0.476457388491672 2232 1609 A potent and irreversible inhibitor of serine proteases. SGTC_246 cycloheximide 667 µM 0.0587021180356363 0.485231485876291 no 1607 0.476594686150438 2215 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_771 0250-0039 27.3 µM 0.0579615294536599 0.485514731040989 no 1608 0.476889636015893 2174 3005115 SGTC_2594 a-mangostin 100 µM 0.0577618892930632 0.485591086580539 no 1609 0.476969147703555 2276 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2419 paclitaxel 166.5 µM 0.0573064929773647 0.485765262082516 no 1610 0.477150524103548 2177 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1997 st073024 93.8 µM 0.0568422155795618 0.485942837128809 no 1611 0.477335442556042 2313 686268 SGTC_2511 berberine 10.47 µM 0.0566427893259409 0.486019113778664 no 1612 0.477414874143916 2290 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3146 9095609 49.47 µM 0.0565702692154929 0.486046851432523 no 1613 0.477443759166927 2264 17173999 SGTC_46 0329-0187a 2.197 µM 0.056171072704449 0.486199538210857 no 1614 0.477602762702525 2250 46494817 SGTC_3043 9092303 49.47 µM 0.0561100059118614 0.486222895537415 no 1615 0.477627086466459 2265 25236084 SGTC_2061 5245884 80.95 µM 0.0555943864440681 0.486420115767353 no 1616 0.477832468279557 2292 573863 SGTC_1516 st013856 110 µM 0.0553519015901802 0.486512865392258 no 1617 0.477929057010714 2237 5281404 A mutagen and neurotoxin. SGTC_2003 4023581 200 µM 0.0553261558540115 0.486522713090967 no 1618 0.477939312358354 2241 16641307 SGTC_2106 5357045 167.29 µM 0.055193761648333 0.48657335377096 no 1619 0.477992049422527 2286 668842 SGTC_3062 9077494 49.47 µM 0.0543978326656309 0.486877800518146 no 1620 0.478309102791135 2260 16459633 SGTC_1693 xanthone 101.9 µM 0.0535102259283392 0.487217323468767 no 1621 0.478662691605583 2234 7020 An insecticide. SGTC_318 1488-0629 67.2 µM 0.0523361974340694 0.487666421248409 no 1622 0.4791304057223 2228 3662576 SGTC_1749 st037932 54.2 µM 0.052217214800614 0.487711936219031 no 1623 0.479177808109216 2226 594497 SGTC_1600 coumarin 106 71.1 µM 0.0521966414911906 0.487719806237367 no 1624 0.479186004494695 2276 100336 A hepatotoxic, DNA x-linker. SGTC_135 0933-0004 26.348 µM 0.0516276664064773 0.48793746121061 no 1625 0.479412687063333 2245 21230617 YGL099W LSG1 SGTC_273 hydroxyurea 18.1 mM 0.0514299655928188 0.488013090261665 no 1626 0.479491453635952 2329 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1634 st006576 41 µM 0.0513186789300671 0.488055662378917 no 1627 0.479535792040679 2308 3915356 SGTC_3001 9076041 71.4286 µM 0.0511082542917775 0.488136159569714 no 1628 0.479619629308458 2303 16004211 SGTC_2807 7945238 51.95 µM 0.0492973760514508 0.48882892417997 no 1629 0.480341155292445 2287 17148797 SGTC_504 lovastatin 124 µM 0.0491572691746456 0.488882524513813 no 1630 0.480396982164887 2245 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2375 9072683 200 µM 0.0478449270722927 0.489384593533615 no 1631 0.480919915453766 2337 16798029 SGTC_1323 1348-1351 11.2 µM 0.0470742540385966 0.489679441507521 no 1632 0.481227023441878 2194 6989654 SGTC_1270 0831-1170 17.3 µM 0.0468730280725288 0.489756428487029 no 1633 0.481307212469236 2327 6764716 SGTC_3284 9108171 64.8615 µM 0.0468676026535624 0.489758504201673 no 1634 0.481309374522119 2260 8687505 SGTC_1059 3448-6867 171 µM 0.046021611072521 0.490082176040574 no 1635 0.481646512506028 2340 3934407 SGTC_88 0180-0332 8.668 µM 0.0453642455080338 0.490333685097949 no 1636 0.48190848979206 2330 3101745 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.045312888311933 0.49035333460187 no 1637 0.481928957301811 2308 15053 SGTC_1953 st076800 12.1 µM 0.0447138700482701 0.490582523513445 no 1638 0.482167689028172 2129 297591 SGTC_2930 9013230 14.89 µM 0.0445042997414155 0.490662707433636 no 1639 0.482251212338323 2308 2995857 SGTC_2270 7924575 90.91 µM 0.0430519170468408 0.491218415329576 no 1640 0.482830074184868 2343 1262135 SGTC_3030 9087619 49.47 µM 0.0425744728838539 0.491401097879727 no 1641 0.483020372360873 2316 25236973 SGTC_59 0330-0160 1.33 µM 0.0422382812514599 0.491529734623595 no 1642 0.483154372875919 2249 4293482 SGTC_993 3909-8757 62.7 µM 0.0422319256834175 0.491532166458198 no 1643 0.483156906120314 2293 4288324 YLR208W SEC13 SGTC_390 dec-rvkr-cmk 16.7 µM 0.0419757100051034 0.491630202669551 no 1644 0.483259030827046 2298 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_3236 9132701 49.47 µM 0.0416797944994309 0.491743429917597 no 1645 0.483376980807777 2281 24282524 SGTC_1395 3486-0190 4.35 µM 0.0413284387620978 0.491877871330401 no 1646 0.483517030789712 2342 6748079 SGTC_1864 st057645 30.4 µM 0.0411042338351178 0.491963660727611 no 1647 0.483606399672803 2339 688666 SGTC_412 gemfibrozil 100 µM 0.0396669092905034 0.492513644840762 no 1648 0.484179341731823 2336 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1091 telmisartan 47.6 µM 0.0394349328903609 0.492602410660354 no 1649 0.484271814570904 2303 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2231 micatex 6.853 µM 0.0382026154833224 0.493073963218078 no 1650 0.48476306778286 2279 20737 An antifungal of unknown mechanism. SGTC_236 1509-0011 5.31 µM 0.0378769001779543 0.49319860148953 no 1651 0.484892915408716 2330 3107280 SGTC_440 fluspirilene 35.1 µM 0.0372460879891832 0.493439990061192 no 1652 0.485144395592655 2303 3396 An atypical antipsychotic. SGTC_800 3448-7362 155 µM 0.0360478830390371 0.493898505469288 no 1653 0.485622089299881 2344 15991913 SGTC_1088 bifonazole 369 nM 0.0359968500091385 0.49391803439055 no 1654 0.485642435328305 2338 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_824 1304-0008 100 µM 0.0358229728006688 0.493984572471686 no 1655 0.485711757587582 2316 768245 SGTC_1887 st057648 70.8 µM 0.0347400756792957 0.494398971457676 no 1656 0.486143502215076 2341 688672 SGTC_402 epigallocatechin gallate 10 µM 0.0347255615320647 0.494404525718843 no 1657 0.486149289030501 2245 65064 An antioxidant. SGTC_716 1683-5115 658 µM 0.0343812402807015 0.494536290589845 no 1658 0.486286571357306 2360 723597 SGTC_1299 1079-1439 3.74 µM 0.0338852449760955 0.49472609913805 no 1659 0.486484329617683 2331 323161 SGTC_3056 9094900 49.47 µM 0.0337874901925157 0.494763508290742 no 1660 0.486523305815641 2331 25236784 SGTC_2750 bromebric acid 70.15 µM 0.0334469070558482 0.494893844229842 no 1661 0.486659102073745 2306 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2082 5219693 150 µM 0.0329821682852598 0.495071693501097 no 1662 0.486844403775883 2348 2834649 SGTC_1817 st052116 64.4 µM 0.0326393046057479 0.495202903445556 no 1663 0.486981112986807 2343 4361398 SGTC_3303 9125618 40.5795 µM 0.0312532912017971 0.495733319805792 no 1664 0.487533770207097 2306 22695467 SGTC_1813 st051246 8.6015 µM 0.0308232499740356 0.495897894757225 no 1665 0.48770524921472 2355 5291959 SGTC_1676 st018489 23.4 µM 0.0304516828265564 0.49604009248971 no 1666 0.487853413505157 2235 3696235 SGTC_2149 5554786 194.827 µM 0.0303269070428472 0.49608784395508 no 1667 0.487903168860746 2327 745063 YPR165W RHO1 SGTC_1735 st034310 56.75 µM 0.0302349159971723 0.496123048796798 no 1668 0.487939851156801 2273 871153 SGTC_1929 genistein trimethyl ether 50.5 µM 0.0270841541108029 0.497328857260504 no 1669 0.489196306656508 2378 136420 SGTC_2670 beta-carotene 100 µM 0.0251186728868097 0.498081067401448 no 1670 0.489980153035569 2365 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_3317 9138495 8.753 µM 0.0247514056555585 0.498221625233944 no 1671 0.490126625919209 2353 17020139 SGTC_2846 9008642 19.48 µM 0.0228256591862811 0.498958636067986 no 1672 0.490894670141831 2307 2992898 SGTC_1339 1486-1321 22.7 µM 0.0227240988449971 0.498997504790056 no 1673 0.490935176349415 2360 3469382 SGTC_702 1488-0190 94 µM 0.0220614405076198 0.499251114658328 no 1674 0.491199472500693 2360 949357 SGTC_737 1950-0117 57.9 µM 0.0212296412436686 0.49956945786107 no 1675 0.491531234657055 2370 5393513 SGTC_3072 9116419 49.47 µM 0.0203539959201865 0.499904581961329 no 1676 0.491880491088184 2357 17170162 SGTC_1482 3346-2049 8.48 µM 0.0198553607014077 0.499904581961329 no 1677 0.492079377558565 2365 3826804 SGTC_633 0437-0093 97.7 µM 0.0192799571758131 0.499684365392865 no 1678 0.492308886407147 2371 2831118 SGTC_144 4161-2749 112.381 µM 0.0176481565872981 0.499059848718023 no 1679 0.492959769623423 2364 797501 YMR168C CEP3 SGTC_468 gf-109203x 121 µM 0.0173827045242774 0.498958256065539 no 1680 0.493065653431162 2373 2396 A protein kinase C inhibitor. SGTC_1176 0848-0131 83.3 µM 0.0148614726945617 0.497993345545737 no 1681 0.494071348430906 2369 6769040 SGTC_1729 st035615 45.989 µM 0.0135680147556567 0.497498325386435 no 1682 0.494587311324601 2248 17385451 SGTC_3220 9131269 49.47 µM 0.0127154110640896 0.497172026912116 no 1683 0.494927421604717 2392 17722206 SGTC_2628 lathosterol 100 µM 0.0126163583294078 0.497134118730983 no 1684 0.494966934758986 2374 6710616 SGTC_1845 st056753 3.01 µM 0.0124722202907525 0.497078956131918 no 1685 0.495024432992654 2372 5375839 SGTC_1801 st050089 28.441 µM 0.0109125068141941 0.496482047062831 no 1686 0.495646626048818 2375 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1859 st055998 20 µM 0.0106342902008803 0.496375573155218 no 1687 0.495757611977581 2387 676301 SGTC_1369 1866-0067 208 µM 0.0105184168497527 0.49633122832883 no 1688 0.495803836171117 2363 3531355 SGTC_877 0771-0151 33.1 µM 0.010260191687804 0.496232405511727 no 1689 0.495906847546244 2319 6166523 SGTC_258 haloperidol 50.781 µM 0.0101606692188076 0.496194318305879 no 1690 0.4959465491974 2386 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2423 st077119 87.2 µM 0.0090992065940806 0.49578809924601 no 1691 0.496369991863009 2370 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2262 9014885 67.46 µM 0.00883809580910995 0.495688173462549 no 1692 0.496474155805321 2360 6457424 SGTC_2052 5265182 7.135 µM 0.00848403823463982 0.49555267784379 no 1693 0.49661539904302 2389 1239884 SGTC_2863 9028737 58.44 µM 0.00835765034009749 0.495504310110683 no 1694 0.496665818730173 2393 6460917 SGTC_1630 st005209 31.3 µM 0.00806342481192575 0.49539171238634 no 1695 0.496783193776547 2394 3367314 SGTC_2127 5253358 187.912 µM 0.0079545333106863 0.495350040584201 no 1696 0.49682663380712 2393 20612 SGTC_630 4356-0227 183 µM 0.00795242898942497 0.495349235279801 no 1697 0.496827473283291 2393 779312 SGTC_522 1273-0010 11.6 µM 0.00784846585614056 0.495309449568215 no 1698 0.49686894727838 2370 5705015 SGTC_932 2857-0803 154 µM 0.00581406287871507 0.494530912598579 no 1699 0.497680537564367 2388 674898 SGTC_3071 9117417 49.47 µM 0.00513392717037509 0.494270638874166 no 1700 0.497951868384412 2395 45595590 YGL055W OLE1 SGTC_123 0083-0120 66.675 µM 0.0046699793700619 0.49409309713755 no 1701 0.498136954552451 2395 16001701 SGTC_1470 k295-0292 231 µM 0.00435996565364695 0.493974462946372 no 1702 0.498260630870362 2397 5045612 SGTC_2075 5212009 200 µM 0.00408845116896044 0.493870561847876 no 1703 0.498368948511302 2395 780898 SGTC_35 0133-0054 64.071 µM 0.00252501905963459 0.493272287844419 no 1704 0.498992664208708 2400 99677 SGTC_1644 st010134 20.9 µM 0.0024482674619121 0.493242917913167 no 1705 0.499023283571454 2401 3818134 SGTC_2680 butyl paraben 22.24 µM 0.00242436378089852 0.493233770886716 no 1706 0.499032819732166 2399 7184 An antifungal and steroid mimetic. SGTC_3067 9117431 49.47 µM 0.00139643013903364 0.49284042334238 no 1707 0.49944290515697 2401 17150885 SGTC_486 niguldipine 82 µM 0.00131962261776657 0.492811032566372 no 1708 0.499473546896393 2404 1236 A calcium channel blocker. SGTC_2474 5321570 43.32 µM 0.000254588991333077 0.492403496300832 no 1709 0.49989843368833 2403 2841384 SGTC_1446 4239-0190 62 µM -0.000133029578010077 0.492255175582971 no 1710 0.499946928876944 2406 1340085 SGTC_1524 corynanthine 62.1 µM -0.000679414125995912 0.492046105512353 no 1711 0.499728953000091 2415 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_276 colchicine 750 µM -0.00122602078596964 0.491836952638552 no 1712 0.499510888594358 2417 2833 A microtubule depolymerizer. SGTC_1266 0828-0227 32.9 µM -0.00136834453263022 0.491782494427952 no 1713 0.499454109682129 2408 3913820 SGTC_2795 7780010 54.55 µM -0.00164158602887436 0.49167794278375 no 1714 0.499345102220303 2409 953673 SGTC_1648 st011736 69.8 µM -0.00181012907943166 0.491613452669616 no 1715 0.499277863371585 2408 2855514 SGTC_249 wiskostatin 11.211 µM -0.00182470626088212 0.491607874970859 no 1716 0.49927204792718 2407 2775510 A n-wasp and actin depolymerizer. SGTC_2165 5727197 32.143 µM -0.0021804247145205 0.491471766153722 no 1717 0.499130137081404 2421 1361712 SGTC_624 k048-0052 28 µM -0.00269645337698049 0.491274319491158 no 1718 0.498924272044369 2411 6835531 SGTC_2959 9079155 11 µM -0.00454714917622712 0.490566210650002 no 1719 0.498185956189679 2418 16189457 SGTC_323 4013-0906 34.3 µM -0.00474415880727583 0.490490833003603 no 1720 0.498107361566457 2413 2910086 SGTC_3304 9125678 46.087 µM -0.00544492712410658 0.490222715550643 no 1721 0.497827799089785 2422 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2634 4'-methoxyflavone 100 µM -0.0064211385901895 0.489849219565408 no 1722 0.497438353931282 2421 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1969 st069479 40.1 µM -0.00653558337557059 0.48980543386274 no 1723 0.497392698025727 2425 3895485 SGTC_862 0452-0056 10.2 µM -0.00779235647630932 0.489324610250537 no 1724 0.496891330997827 2424 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.00872455535752593 0.488967974126541 no 1725 0.496519450145574 2420 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1268 0828-0275 2.46 µM -0.00903801539094974 0.488848054075682 no 1726 0.496394402617336 2442 745337 SGTC_3278 9139605 49.47 µM -0.00931852831177746 0.488740739418941 no 1727 0.496282498866909 2444 7958859 SGTC_2788 5282734 71.43 µM -0.0109205502067404 0.488127876447137 no 1728 0.495643417390648 2434 743706 SGTC_2956 9076196 2.52 µM -0.0123749255159313 0.487571520790194 no 1729 0.495063244996639 2421 16423868 SGTC_935 2996-0153 430 µM -0.0124262882279799 0.48755187297205 no 1730 0.495042755814592 2435 23738523 SGTC_3241 9133421 49.47 µM -0.0125611487256381 0.48750028482504 no 1731 0.49498895845902 2424 17018221 SGTC_1209 2323-2347 50.3 µM -0.0144627253293476 0.48677289794626 no 1732 0.494230408514975 2430 5412760 SGTC_747 3448-8087 38.7 µM -0.0155671092397591 0.486350471497366 no 1733 0.493789872763396 2454 5168703 SGTC_3135 9127742 49.47 µM -0.0158095689974839 0.48625773276093 no 1734 0.49369315721772 2467 3643468 SGTC_322 k048-0136 19.3 µM -0.016093050972853 0.486149304327883 no 1735 0.493580078659404 2466 6823282 SGTC_775 4577-0580 57.3 µM -0.016718587301587 0.485910047868414 no 1736 0.493330559355445 2527 2006902 SGTC_3269 9137823 49.47 µM -0.0168491821722892 0.48586009830286 no 1737 0.493278466877666 2445 17682936 SGTC_1445 4239-0156 97.7 µM -0.0176070640615813 0.485570230134645 no 1738 0.492976160622532 2448 4008346 SGTC_953 1188-0045 9.7 µM -0.0183650639133252 0.485280324475389 no 1739 0.492673811349093 2453 6144426 SGTC_2176 5809774 33.9695 µM -0.0193215917512535 0.48491450065348 no 1740 0.49229227970813 2447 2870539 SGTC_2839 9003951 25.97 µM -0.0201791676430611 0.484586531762757 no 1741 0.491950223157502 2437 2990634 SGTC_994 3910-0338 138 µM -0.0203624589743129 0.484516435691046 no 1742 0.49187711551766 2467 3479481 SGTC_2427 5545055 42.75 µM -0.020976700540044 0.484281534897556 no 1743 0.491632120930856 2446 5372858 SGTC_1561 5-methoxyflavone 52.9 µM -0.021929686961586 0.483917100725664 no 1744 0.49125202184741 2440 94525 SGTC_1155 4088-0394 48.2 µM -0.0225307516492567 0.483687252806704 no 1745 0.491012290976587 2443 2326248 SGTC_3047 9092122 49.47 µM -0.0237436374673763 0.483223460275628 no 1746 0.490528549070135 2451 17173831 SGTC_3314 9135860 59.4275 µM -0.024455099097685 0.482951416673148 no 1747 0.490244799360884 2448 25252478 SGTC_2181 6316240 54.2555 µM -0.0261406914033421 0.482306923868564 no 1748 0.489572560547491 2470 12779990 SGTC_3346 9158254 43.5805 µM -0.0262899560635121 0.482249854146207 no 1749 0.489513033022093 2471 17639500 SGTC_256 clotrimazole 625 nM -0.027147881064387 0.481921842924948 no 1750 0.489170892625238 2438 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2570 licareol 100 µM -0.0274909889006407 0.481790665616965 no 1751 0.489034063474142 2506 443158 SGTC_1505 k297-0037 20.6 µM -0.0277512779437556 0.481691152981553 no 1752 0.488930262773743 2460 4089396 SGTC_1947 st076332 61.6 µM -0.0281990457679762 0.481519966903039 no 1753 0.488751699144834 2450 24208416 SGTC_463 ikarugamyin 104 µM -0.0283833420003557 0.481449509614294 no 1754 0.488678205003658 2460 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_395 anisomycin 6.25 µM -0.0284862588093965 0.481410164301611 no 1755 0.488637163732251 2485 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1192 1488-0095 21.4 µM -0.029094245402568 0.481177733454942 no 1756 0.488394712680121 2502 915875 SGTC_305 1682-2595 20.8 µM -0.0294984328624316 0.481023217738946 no 1757 0.488233534396799 2499 226033 SGTC_531 3788-1495 174 µM -0.029890741877582 0.480873245727337 no 1758 0.488077094731668 2464 2896655 SGTC_2765 myclobutanil 7.74 µM -0.0299417054417742 0.480853763558485 no 1759 0.488056772307275 2504 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_669 0108-0021 26.2 µM -0.0299464244960323 0.480851959577631 no 1760 0.488054890520846 2455 17201 SGTC_3091 9116372 49.47 µM -0.0301246807575086 0.480783816787064 no 1761 0.487983808631433 2562 17169793 SGTC_1453 4237-0541 195 µM -0.0301539722806798 0.480772619443718 no 1762 0.487972128310667 2458 739892 SGTC_2854 9024559 71.43 µM -0.0302775774471031 0.480725368756802 no 1763 0.487922839489048 2480 3163529 SGTC_3155 9099265 49.47 µM -0.0321434175126973 0.480012145237902 no 1764 0.487178839557907 2496 25236499 SGTC_1295 1013-0063 9.78 µM -0.0321773966295633 0.479999157194737 no 1765 0.487165290860005 2462 6826038 SGTC_3227 9130768 49.47 µM -0.0333165399369443 0.479563747940077 no 1766 0.486711082059669 2477 17720899 SGTC_2196 6573537 42.6665 µM -0.0338232528377616 0.479370077315714 no 1767 0.486509046734384 2481 2903087 SGTC_490 phenamil 164 µM -0.0338301607540608 0.47936743707612 no 1768 0.486506292450743 2475 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1866 st057638 64 µM -0.0338817139069645 0.479347733236053 no 1769 0.486485737502033 2498 688802 SGTC_1438 4092-1045 4 µM -0.0351577590487417 0.478860039419115 no 1770 0.485976972393451 2474 1351342 SGTC_1578 josamycin 24.2 µM -0.0352599664659105 0.478820977955569 no 1771 0.485936222799122 2476 5282165 A P450 substrate. SGTC_1289 0976-0073 69.1 µM -0.0354530403709619 0.478747189841678 no 1772 0.485859245584242 2541 3391136 SGTC_1134 3477-0009 42.5 µM -0.0362250898421015 0.478452138763579 no 1773 0.485551440157356 2497 3973534 SGTC_1106 tegaserod maleate 11.7 µM -0.037218012045168 0.478072695013518 no 1774 0.485155588513139 2514 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1212 0520-0165 585 µM -0.0375739858937677 0.477936664956396 no 1775 0.485013674760071 2521 5403258 SGTC_1906 st060206 94.7 µM -0.0378480751323538 0.477831927623203 no 1776 0.484904406698415 2463 5133468 SGTC_876 0720-0963 56.8 µM -0.0381215172596605 0.477727439095389 no 1777 0.484795397742802 2468 765861 SGTC_3167 9103034 49.47 µM -0.0385005699836406 0.477582596862584 no 1778 0.484644288520537 2474 5127859 SGTC_1191 1487-1166 10.6 µM -0.0389087851100847 0.477426614512 no 1779 0.484481556184645 2547 3955771 SGTC_1822 st052468 42 µM -0.0394712703154544 0.477211689968321 no 1780 0.484257329313556 2488 2873678 SGTC_444 curcumin 90.4 µM -0.0399884872069268 0.477014068210664 no 1781 0.484051152415266 2507 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2243 6634756 200 µM -0.0400171190092545 0.477003128541019 no 1782 0.484039739114328 2495 885676 SGTC_145 3737-0113 38.366 µM -0.0407750162935233 0.476713556662856 no 1783 0.483737628449724 2518 6849351 SGTC_1715 st032160 10.2275 µM -0.0417078051439937 0.476357180383638 no 1784 0.483365815885978 2500 5289825 SGTC_1727 st034309 9.9045 µM -0.0423844060161204 0.476098693718771 no 1785 0.483096129687403 2520 870305 SGTC_2166 5933061 31.504 µM -0.0432680160167366 0.475761137038655 no 1786 0.482743943428006 2612 2877375 SGTC_1466 k213-0079 57.5 µM -0.04501874673105 0.475092374526564 no 1787 0.482046183185895 2476 3657981 SGTC_721 1187-1332 279 µM -0.045451446387302 0.474927098107376 no 1788 0.481873737520293 2474 25730 SGTC_1606 st000094 49.2 µM -0.0454812987381056 0.474915695692628 no 1789 0.481861840458496 2480 1242210 SGTC_928 2764-0428 58.7 µM -0.0458775323923374 0.474764352092021 no 1790 0.481703930935624 2600 662578 SGTC_2878 9043973 25.97 µM -0.0460975821930702 0.474680304444369 no 1791 0.481616236546017 2616 6465167 SGTC_2830 7992007 71.43 µM -0.0468392133704743 0.474397047995947 no 1792 0.481320687782963 2487 1952075 SGTC_2713 st079149 53.4 µM -0.0479757715621979 0.473962979439679 no 1793 0.480867775929548 2522 3103253 SGTC_3046 9092212 49.47 µM -0.0484180807887263 0.473794063263723 no 1794 0.480691524909037 2497 25236637 SGTC_1340 1486-1359 257 µM -0.0505640285146387 0.472974601593973 no 1795 0.479836463613385 2555 4309068 SGTC_3297 9117502 71.43 µM -0.05079286654157 0.472887223118137 no 1796 0.479745287608383 2483 7453720 SGTC_925 2064-1272 59.6 µM -0.051425126288887 0.472645810714411 no 1797 0.479493381687563 2525 6815817 SGTC_3335 9143315 29.6265 µM -0.0515379704066391 0.47260272509439 no 1798 0.479448423015518 2521 4899691 SGTC_3069 9117009 49.47 µM -0.0527585320299248 0.472136716481673 no 1799 0.478962151051761 2491 41904981 SGTC_3070 9117005 49.47 µM -0.0530927297941288 0.47200912689658 no 1800 0.478829012034208 2488 8779016 SGTC_1390 3413-2614 145 µM -0.0536187730349505 0.471808300620537 no 1801 0.478619449653823 2524 3421432 SGTC_73 0327-0325 16.231 µM -0.0543299589362031 0.471536804276708 no 1802 0.47833614050791 2610 53298 SGTC_484 loperamide 105 µM -0.0557119647065033 0.47100925932294 no 1803 0.477785633925092 2496 3955 An opioid-receptor agonist. SGTC_2565 isoliquiritigenin 100 µM -0.0561261218168841 0.470851175423577 no 1804 0.477620667266312 2610 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3039 9090270 49.47 µM -0.0561736709029292 0.470833026215942 no 1805 0.477601727805311 2509 17173750 SGTC_1305 1181-0477 144 µM -0.0577194268782915 0.470243053424907 no 1806 0.476986059540729 2553 6252086 SGTC_304 1310-0298 97 µM -0.0579983436034989 0.470136605455406 no 1807 0.476874973960248 2524 1550234 SGTC_3289 9119912 71.43 µM -0.0584671655933629 0.469957685361415 no 1808 0.476688257898851 2569 17014829 SGTC_1452 4194-0072 190 µM -0.0603290144477656 0.469247194079283 no 1809 0.475946796918896 2527 1343545 SGTC_2647 atorvastatin 60.16 µM -0.0603511637357764 0.469238742379754 no 1810 0.475937976702931 2570 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2370 9071495 200 µM -0.060522172382637 0.46917348956632 no 1811 0.475869878604347 2566 21791103 SGTC_385 1494-0393 12.4 µM -0.0609158825538175 0.469023262323026 no 1812 0.475713100243643 2542 3090647 SGTC_526 4469-0568 170 µM -0.060996396533903 0.468992541298806 no 1813 0.475681039431589 2513 2901964 SGTC_63 0099-0242 26.702 µM -0.0617957079646536 0.468687564980859 no 1814 0.475362760752566 2515 3898502 YLR359W ADE13 SGTC_3005 9076496 71.4286 µM -0.0629395614706088 0.468251161051884 no 1815 0.47490731589007 2524 21368410 SGTC_345 1362-0200 395 µM -0.0629703848369726 0.468239401821344 no 1816 0.474895043489894 2542 1419823 SGTC_2986 9022445 71.43 µM -0.0634376147057646 0.46806115526357 no 1817 0.474709017676476 2501 6459286 SGTC_299 1273-0059 1.44 µM -0.0662547229011803 0.466986575311247 no 1818 0.473587514933376 2547 2848077 SGTC_1767 st044992 70.3 µM -0.0666181812330679 0.466847952256886 no 1819 0.473442835683792 2553 9600693 SGTC_2150 5556613 200 µM -0.067277498169995 0.466596498967548 no 1820 0.473180395076843 2562 743190 SGTC_2973 9094665 17.96 µM -0.0675514410019407 0.466492025320287 no 1821 0.47307135575692 2678 25237061 YIL048W NEO1 SGTC_2461 5755302 26.15 µM -0.0680719334999593 0.466293531330959 no 1822 0.472864186170067 2544 2788904 SGTC_1712 st032288 53.4 µM -0.0682450114062409 0.466227528538044 no 1823 0.472795298273541 2539 2883011 SGTC_1636 st007707 68.9 µM -0.0686848989251632 0.466059782803165 no 1824 0.472620219363091 2561 403051 SGTC_3253 9135987 49.47 µM -0.0688520469804697 0.465996044512157 no 1825 0.472553694424579 2544 4182430 SGTC_2889 9059656 51.95 µM -0.0695553225030988 0.465727875196437 no 1826 0.472273799122974 2592 3949838 SGTC_2709 st078560 56 µM -0.0700267282688735 0.465548129938325 no 1827 0.472086192885359 2560 17250903 SGTC_2995 9067767 71.4286 µM -0.0709279599940445 0.465204513240503 no 1828 0.471727545276211 2592 11673567 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.070986666476626 0.465182130851516 no 1829 0.471704183664431 2744 6710655 SGTC_3011 9081274 71.4286 µM -0.0714513256866726 0.465004979125866 no 1830 0.471519280982986 2568 6625322 SGTC_1029 k015-0030 64.7 µM -0.0722527939898466 0.464699434960918 no 1831 0.471200365697332 2656 2208316 SGTC_1419 3993-2473 62.6 µM -0.0724505146383976 0.464624061012285 no 1832 0.471121692757814 2544 704026 SGTC_1165 k072-0275 30.3 µM -0.0730743232733337 0.464386264541731 no 1833 0.470873487039309 2539 6153523 YGL055W OLE1 SGTC_1202 1988-0068 29.6 µM -0.0734149144138275 0.464256436224194 no 1834 0.470737974817878 2543 2850480 SGTC_729 4092-0585 94.1 µM -0.0742897881655746 0.463922964734375 no 1835 0.470389901221099 2540 2169061 SGTC_2313 7726885 200 µM -0.0746079927276896 0.463801682479546 no 1836 0.470263307286701 2610 726423 SGTC_2133 5320837 200 µM -0.0757892036212011 0.463351498705416 no 1837 0.469793402841175 2621 2841355 SGTC_718 1130-0073 349 µM -0.0765744112726687 0.46305226584435 no 1838 0.469481058007281 2615 6740020 SGTC_1744 st037937 38.9 µM -0.0766714526453645 0.463015286033279 no 1839 0.469442457580235 2628 1016152 SGTC_2333 9017922 200 µM -0.0775745503616083 0.462671155581572 no 1840 0.469083243614856 2631 3163164 SGTC_1716 st033144 30.6155 µM -0.0781244224667707 0.462461637397898 no 1841 0.468864540122093 2567 674617 SGTC_285 1486-1325 46 µM -0.0784175402690804 0.462349954752133 no 1842 0.468747960688526 2596 22310230 SGTC_2055 5235184 200 µM -0.0785548056415475 0.462297655434617 no 1843 0.468693368134305 2620 2836034 SGTC_1329 1447-1697 50.6 µM -0.0790745516393352 0.462099633539784 no 1844 0.468486662483343 2661 2840515 SGTC_2898 9056270 58.44 µM -0.0791522292218356 0.462070039385376 no 1845 0.468455770438432 2529 19154699 SGTC_2018 5133068 143 µM -0.0808392246163127 0.461427368036385 no 1846 0.467784906700419 2542 785362 SGTC_372 0155-0182 15.9 µM -0.0813732113030768 0.461223963404705 no 1847 0.467572576363876 2551 771486 SGTC_1129 3453-1384 223 µM -0.0815728333720657 0.461147926557671 no 1848 0.467493202554087 2758 1084452 SGTC_1119 parthenolide 318.541 nM -0.082180533352277 0.460916459951821 no 1849 0.467251576605727 2721 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1627 st003713 25.6 µM -0.0825709842619689 0.460767748240502 no 1850 0.467096336835307 2605 16195070 YER133W GLC7 SGTC_690 glyoxal 20.3 µM -0.0828610269241203 0.460657282742076 no 1851 0.466981021719607 2554 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2183 6420625 130.508 µM -0.0840345872726631 0.460210352236481 no 1852 0.466514466174181 2542 2897619 SGTC_1161 k007-0610 110 µM -0.0844252527913145 0.460061585039745 no 1853 0.466359165066349 2577 5843850 SGTC_161 4065-0411 162.148 µM -0.0844632279492341 0.46004712422564 no 1854 0.466344069089736 2631 1906281 YLR208W SEC13 SGTC_900 1112-0045 141 µM -0.0853600285246132 0.459705640944698 no 1855 0.46598758487709 2586 56211 YIL048W NEO1 SGTC_3205 9113483 49.47 µM -0.0870099329235099 0.459077468987369 no 1856 0.465331808361192 2676 17018033 SGTC_193 1273-0060 1.558 µM -0.0877530870868478 0.458794559444054 no 1857 0.465036462467437 2551 2847393 YHR072W ERG7 SGTC_787 4152-0075 138 µM -0.0889855027071976 0.458325440220556 no 1858 0.464546715786745 2604 9566539 SGTC_340 k038-0059 454 µM -0.0899122650553193 0.457972706167506 no 1859 0.464178467263206 2545 23733424 SGTC_493 zm226600 134 µM -0.0911530277314825 0.457500512642493 no 1860 0.463685498971922 2717 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1318 1280-3875 124 µM -0.0914920782922079 0.457371491541817 no 1861 0.463550800222305 2618 373245 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.0917616593820257 0.457268909313319 no 1862 0.463443703437426 2564 803109 SGTC_1256 0570-0116 285 µM -0.094163787214851 0.456354967149179 no 1863 0.462489525267407 2608 410638 SGTC_373 0844-0104 25.9 µM -0.0945448415155878 0.45621000778231 no 1864 0.462338181783852 2617 5375804 SGTC_1893 st059353 36.1 µM -0.0946962339787225 0.456152417198704 no 1865 0.462278054693092 2627 3112488 SGTC_2595 hexamethylquercetagetin 100 µM -0.0963479177546862 0.455524167077091 no 1866 0.461622127604371 2657 386331 SGTC_1347 1493-0251 600 nM -0.0971917275745187 0.455203250381451 no 1867 0.461287068691604 2650 3986378 SGTC_2496 diffractaic acid 79.83 µM -0.0979850186389616 0.454901573569795 no 1868 0.460972094755774 2611 94870 An apoptosis inducer which activates caspases. SGTC_1628 st004252 77.7 µM -0.0985708205303097 0.454678818493532 no 1869 0.460739519502898 2668 692968 SGTC_3163 9099914 49.47 µM -0.0993448311283421 0.454384517667879 no 1870 0.460432242176702 2587 16268368 SGTC_580 1123-0028 41 µM -0.0998479391477416 0.454193235119163 no 1871 0.460232524124343 2576 1677248 YPR107C YTH1 SGTC_1425 4048-4433 7.33 µM -0.100793568345069 0.45383373402898 no 1872 0.459857166278586 2598 23734946 SGTC_1774 st048371 48.465 µM -0.101302174969182 0.453640392006329 no 1873 0.459655294851121 2588 4242727 SGTC_1531 st059297 52.4 µM -0.101580780765494 0.453534487288975 no 1874 0.459544717626397 2685 7566702 SGTC_502 l-744,832 89.3 µM -0.101604570040382 0.45352544457042 no 1875 0.45953527592898 2607 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1067 clotrimazole 1.36 µM -0.10161849602112 0.453520151073287 no 1876 0.459529748873403 2603 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_666 0272-0154 136 µM -0.101821742774594 0.453442894538675 no 1877 0.459449083552932 2621 6870312 SGTC_1100 amiodarone 5.07 µM -0.10189145132673 0.453416397885539 no 1878 0.459421417750178 2592 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1143 3454-2408 5.08 µM -0.10296256350118 0.453009287647191 no 1879 0.458996341495083 2561 X1143 SGTC_1310 1188-0297 994 nM -0.103999810363078 0.45261509606128 no 1880 0.458584749531797 2638 1588352 SGTC_2234 tolnaftate 200 µM -0.104765017697333 0.452324319314449 no 1881 0.458281134541105 2597 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2229 7354935 190 µM -0.104983755869845 0.452241204084482 no 1882 0.458194349210808 2590 318112 SGTC_948 3448-0295 75.3 µM -0.105103034040252 0.452195882138083 no 1883 0.458147025912424 2598 678569 SGTC_3118 9124250 49.47 µM -0.106244627500306 0.451762144189497 no 1884 0.457694131836011 2667 1504786 SGTC_573 3702-0553 84.7 µM -0.107216153905173 0.451393066982749 no 1885 0.457308750168392 2607 1222756 SGTC_1364 1653-0028 37.6 µM -0.107437762962241 0.451308884869591 no 1886 0.457220848678706 2670 5718652 SGTC_1733 st037357 54.9 µM -0.108866163851985 0.450766334278326 no 1887 0.456654322212721 2594 1272339 YGL099W LSG1 SGTC_2396 5342950 42.78 µM -0.113096864823618 0.449159927419545 no 1888 0.454976880277148 2659 1886677 SGTC_2199 6590217 200 µM -0.113355871468151 0.449061608794861 no 1889 0.454874211805539 2639 703109 SGTC_1912 st060209 90.8 µM -0.114207460201502 0.448738368769805 no 1890 0.454536669110482 2672 688787 SGTC_2825 7998094 58.44 µM -0.114419142259168 0.448658025263935 no 1891 0.454452770158637 2676 2987815 SGTC_1093 fluphenazine 7.97 µM -0.115032590817554 0.448425203982137 no 1892 0.45420964488246 2627 6602611 An atypical antipsychotic. SGTC_826 1683-5028 118 µM -0.115394104940146 0.448288007340814 no 1893 0.454066375663389 2683 722377 SGTC_1692 fluoroquinolonic acid 71 µM -0.116135617928623 0.448006618365226 no 1894 0.453772530383323 2719 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_665 3914-0008 307 µM -0.1167365190031 0.447778607911187 no 1895 0.453534425064374 2608 1069549 SGTC_2362 9071156 126 µM -0.116915884290258 0.44771055152879 no 1896 0.453463355319178 2738 653133 SGTC_1101 ebselen 5.29 µM -0.117768089711654 0.447387221186211 no 1897 0.453125707138206 2622 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2724 maprotiline 69.64 µM -0.118520638778517 0.447101729946665 no 1898 0.452827571484186 2626 4011 A tricyclic antidepressant. SGTC_1934 st074720 32.6 µM -0.119015489375094 0.446914015573717 no 1899 0.452631542128461 2617 17250992 SGTC_1269 0831-0796 3.05 µM -0.119270836963134 0.446817157830995 no 1900 0.45253039363951 2682 927758 SGTC_53 0973-0023 39.979 µM -0.119289881414217 0.446809934069397 no 1901 0.452522849859816 2604 674768 SGTC_1196 1588-0294 184 µM -0.119312880371497 0.446801210345325 no 1902 0.452513739666454 2680 6144269 SGTC_2366 9070441 60.58 µM -0.120207175866134 0.446462015529109 no 1903 0.452159516739087 2636 6837235 SGTC_3113 9123498 49.47 µM -0.120246885266098 0.446446955169175 no 1904 0.452143789060431 2599 8897275 SGTC_2671 danthron 100 µM -0.121619907618459 0.445926264392761 no 1905 0.4516000232646 2658 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_3305 9127027 53.8275 µM -0.122130085319996 0.445732813597034 no 1906 0.451397997790644 2682 41905295 SGTC_779 1360-0071 233 µM -0.122301741292201 0.445667727444466 no 1907 0.451330026500445 2818 7566 SGTC_1407 3909-7909 12.3 µM -0.12248651927522 0.445597667504613 no 1908 0.451256860830844 2630 4411780 SGTC_2774 tamoxifen 10.92 µM -0.122734553592874 0.445503626128382 no 1909 0.451158650451408 2608 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_3230 9131665 49.47 µM -0.122973009451489 0.445413219283485 no 1910 0.451064235527523 2606 15943720 SGTC_2529 gangaleoidin 93.61 µM -0.123164436255986 0.445340644829788 no 1911 0.450988443430702 2645 4565183 SGTC_987 1497-1013 404 µM -0.123392389856479 0.445254224588716 no 1912 0.450898191518689 2621 1676435 SGTC_2431 5490079 200 µM -0.124555141764188 0.444813450444759 no 1913 0.450437871715241 2666 5722345 SGTC_2885 9057732 51.95 µM -0.12629592916405 0.444153683225039 no 1914 0.449748839257384 2755 6471414 SGTC_2076 5212012 200 µM -0.126374777753263 0.444123802860624 no 1915 0.449717633251363 2588 604802 SGTC_632 0781-2353 4.65 µM -0.128020211313686 0.443500324105319 no 1916 0.44906648916695 2717 6811515 YHR007C ERG11 SGTC_1381 2324-0066 62.1 µM -0.128537956426976 0.443304171787143 no 1917 0.448861631228446 2748 10885928 SGTC_2232 chlorophetanol 41.5365 µM -0.128736663621918 0.443228893494231 no 1918 0.44878301170603 2656 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3090 9117696 49.47 µM -0.129990440219169 0.442753959754997 no 1919 0.448286995057712 2743 7923821 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.130220656792147 0.442666762053737 no 1920 0.448195925988107 2641 688662 SGTC_454 lyso-paf C-16 6.67 µM -0.13149968089547 0.442182364729469 no 1921 0.447690019495621 2699 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_523 1934-0222 13.7 µM -0.132464672839048 0.441816956138426 no 1922 0.447308381870192 2650 1361595 SGTC_687 k029-0044 34.9 µM -0.132719302701618 0.441720544986243 no 1923 0.44720768828275 2709 5829338 SGTC_78 0336-0123 156.75 µM -0.132928457700694 0.441641354679783 no 1924 0.447124980312495 2620 6765896 SGTC_726 3448-4391 34.2 µM -0.133795040417043 0.441313273852323 no 1925 0.446782324554257 2783 1356692 SGTC_846 0335-0850 148 µM -0.134578468766452 0.441016709208634 no 1926 0.446472583076338 2654 6819598 SGTC_274 sirtinol 40.1 µM -0.134842748212008 0.440916674404469 no 1927 0.446368103141783 2685 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1374 2889-5571 141 µM -0.135265367847607 0.440756712659407 no 1928 0.446201032917605 2706 2853281 SGTC_3226 9131256 49.47 µM -0.135842996642248 0.44053809550905 no 1929 0.445972699841387 2624 17178073 SGTC_3280 9140961 49.47 µM -0.136949230954432 0.44011946586086 no 1930 0.445535462360519 2626 4901226 SGTC_1846 st056244 14.8 µM -0.140878084020422 0.438633223375915 no 1931 0.443983127938741 2720 5393182 SGTC_2361 9034121 116 µM -0.141758652183302 0.438300231905193 no 1932 0.443635322467315 2697 6496917 SGTC_1345 1488-0192 31.4 µM -0.141776183134064 0.438293602926847 no 1933 0.443628398558969 2692 658348 SGTC_3165 9101544 49.47 µM -0.142124873273012 0.438161756325155 no 1934 0.443490685786195 2753 5002184 SGTC_257 daunorubicin 18.5 µM -0.142470778215792 0.438030969642636 no 1935 0.443354079750441 2785 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2117 5521686 200 µM -0.142826810438596 0.437896360903746 no 1936 0.443213481243151 2665 803312 SGTC_1563 conessine 56.1 µM -0.143150348851706 0.437774043663186 no 1937 0.443085720867436 2759 441082 An anti-amoebic, histamine inhibitor. SGTC_3024 9090631 49.47 µM -0.143554055735003 0.437621426193928 no 1938 0.442926311487255 2662 25236383 SGTC_2349 9023730 187.07 µM -0.143739841944688 0.437551194636954 no 1939 0.442852954273649 2769 4126287 SGTC_1504 k297-0033 30 µM -0.144307340416775 0.43733667905964 no 1940 0.442628891082987 2614 4388117 SGTC_2337 9009472 200 µM -0.144921643630625 0.437104491957283 no 1941 0.442386368843443 2749 5742383 SGTC_720 r052-1644 49.9 µM -0.147999224076396 0.435941591984951 no 1942 0.441171690298186 2784 1422863 YOR257W CDC31 SGTC_197 4544-0043 41.561 µM -0.148426045790817 0.435780355864947 no 1943 0.441003273076655 2679 896523 SGTC_3231 9132313 49.47 µM -0.148457037925166 0.435768648695298 no 1944 0.440991044476751 2712 4905967 SGTC_1885 st057546 99.9 µM -0.148638546296121 0.435700085677567 no 1945 0.440919427652941 2823 702008 SGTC_1039 k821-0043 94 µM -0.148782100256839 0.435645860936886 no 1946 0.44086278767368 2752 15992768 SGTC_2004 4023728 41.89 µM -0.149805271933687 0.435259412666316 no 1947 0.440459124948461 2738 360084 YDR527W RBA50 SGTC_497 capsazepine 133 µM -0.149910734439453 0.435219583364852 no 1948 0.44041752128406 2681 2733484 A calcium channel blocker. SGTC_217 ketoconazole 989 nM -0.150193284604522 0.435112877821555 no 1949 0.440306061954055 2743 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_840 0245-0196 390 µM -0.150824160033361 0.434874643723514 no 1950 0.440057213663163 2799 3827528 SGTC_62 0180-0423 3.232 µM -0.151599178907455 0.434582009880832 no 1951 0.439751540529442 2699 30102 YGL099W LSG1 SGTC_1008 4106-0037 6 µM -0.151763482864084 0.434519976121725 no 1952 0.439686742450361 2652 2905394 SGTC_2674 ligustilide 100 µM -0.152562396790932 0.434218365282167 no 1953 0.439371690396806 2765 5319022 A signalling regulator. SGTC_2794 7785382 27.27 µM -0.152578089537498 0.434212441244002 no 1954 0.43936550233927 2654 2205081 SGTC_99 0109-0120 622.8 µM -0.152638203916077 0.434189748101909 no 1955 0.439341797815635 2695 759414 SGTC_266 formosanin C 406 nM -0.153413458019588 0.433897109598945 no 1956 0.439036116275664 2705 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_111 0083-0039 52.457 µM -0.153435796462325 0.433888677947034 no 1957 0.439027308798905 2662 759313 SGTC_2722 naftopidil 47.16 µM -0.153454981082909 0.43388143673025 no 1958 0.43901974481767 2675 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_153 4077-0274 519.67 µM -0.155124421874931 0.433251393133577 no 1959 0.438361614678476 2760 3121976 SGTC_2915 7971052 15.16 µM -0.155787964994927 0.433001020308618 no 1960 0.438100078669618 2665 5741558 SGTC_2667 digitoxin 100 µM -0.155827283263308 0.432986185301995 no 1961 0.438084582192521 2748 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_728 3030-5151 22.5 µM -0.156404455946837 0.432768425640197 no 1962 0.437857112531618 2675 3125388 SGTC_1262 0737-0114 49.6 µM -0.157169831035904 0.432479691183858 no 1963 0.437555502057218 2720 765919 SGTC_750 4073-0104 132 µM -0.157424375358793 0.432383673415495 no 1964 0.437455202101609 2752 22330957 SGTC_3169 9102970 49.47 µM -0.158237559499314 0.43207695548004 no 1965 0.437134804185291 2675 17027839 SGTC_492 tmb-8 126 µM -0.158284223390039 0.432059355968404 no 1966 0.437116419667986 2687 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_363 0455-0021 3.06 µM -0.159229789843121 0.431702760110293 no 1967 0.436743917184055 2696 4597466 SGTC_1265 0819-1001 68.8 µM -0.159469520233448 0.431612360843736 no 1968 0.436649485162556 2659 3106768 SGTC_320 4092-0846 5.34 µM -0.161599748272102 0.430809236916435 no 1969 0.435810527778395 2794 1359356 SGTC_1559 coumarin 343 70.1 µM -0.163548547932808 0.430074764325625 no 1970 0.435043275978554 2824 108770 A hepatotoxic, DNA x-linker. SGTC_2740 felodipine 17.08 µM -0.164402280931521 0.429753081547345 no 1971 0.434707234041109 2792 3333 L-type calcium channel blocker SGTC_675 1309-0189 238 µM -0.164884520752502 0.429571396333498 no 1972 0.434517438142512 2739 4246530 SGTC_164 4100-3994 89.624 µM -0.167051542744206 0.428755149332456 no 1973 0.433664746714721 2705 4615967 SGTC_983 1491-0821 12.2 µM -0.167877205302544 0.428444228942246 no 1974 0.433339941570611 2853 46495113 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.169916555717998 0.427676459877232 no 1975 0.432537880435997 2679 6312947 SGTC_3151 9099821 49.47 µM -0.172127140438945 0.426844534292109 no 1976 0.431668788102671 2829 17174189 SGTC_621 3584-0052 32.1 µM -0.172140069137698 0.426839669693213 no 1977 0.431663706147683 2728 2273927 SGTC_2321 7390090 138.78 µM -0.173687966978022 0.426257332683953 no 1978 0.431055347372632 2810 649046 SGTC_460 trequinsin 123 µM -0.173882041647419 0.426184330871143 no 1979 0.430979083157184 2745 5537 A vasodilator. SGTC_2100 5377183 190 µM -0.17513591201662 0.425712744554167 no 1980 0.430486420313127 2807 2844202 SGTC_3272 9137413 49.47 µM -0.175615375588296 0.425532444178889 no 1981 0.430298061058301 2709 17614870 SGTC_3139 9095020 49.47 µM -0.176036807658731 0.425373979176097 no 1982 0.430132512814553 2667 25236292 SGTC_3328 9140624 29.0385 µM -0.176748191989188 0.425106514982061 no 1983 0.429853092508288 2893 4904392 SGTC_1303 1160-0052 261 µM -0.179236773749911 0.424171137289838 no 1984 0.428875894981825 2740 3562476 SGTC_1234 0326-0494 15.5 µM -0.180246686927595 0.423791664967287 no 1985 0.42847945386435 2870 1547813 SGTC_183 3914-0051 30.55 µM -0.180432917416006 0.423721697037948 no 1986 0.428406357009916 2843 1596232 SGTC_1428 4049-0204 61.7 µM -0.182181862117489 0.42306472548718 no 1987 0.427720003362406 2822 X1428 SGTC_3288 9119690 36.221 µM -0.182654666321389 0.422887158516189 no 1988 0.427534494138795 2777 17595618 YKL019W RAM2 SGTC_711 k292-0785 179 µM -0.182763490200061 0.422846290693147 no 1989 0.427491798322085 2714 4146315 SGTC_1568 digitonin 820 nM -0.186280017702366 0.421526139938418 no 1990 0.42611258838217 2827 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1175 0741-0056 27.6 µM -0.187110234374954 0.421214593743387 no 1991 0.425787102000669 2915 765927 SGTC_1173 0443-0020 122 µM -0.187837748393631 0.420941628173594 no 1992 0.42550192174245 2750 5331295 SGTC_553 k007-0256 45.7 µM -0.18823847487893 0.420791290546349 no 1993 0.425344856479326 2782 6287000 SGTC_520 3584-0023 682 µM -0.189026286843322 0.420495766584688 no 1994 0.425036107126504 2808 1340790 SGTC_743 1275-0778 158 µM -0.189360848912535 0.420370279232624 no 1995 0.42490500366686 2858 2849257 YMR203W TOM40 SGTC_1571 st070080 73.4 µM -0.189524799114529 0.420308787837346 no 1996 0.424840760208109 2878 4315245 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.189578961308415 0.420288474115416 no 1997 0.424819537332368 2735 229346 A bile salt which induces apoptosis. SGTC_1426 4048-4480 71.7 µM -0.189864714176895 0.420181305010017 no 1998 0.424707571739596 2838 14224343 SGTC_880 0833-0487 87.2 µM -0.190608565856413 0.419902357736817 no 1999 0.424416139328086 2753 76075 SGTC_1967 st070177 51.4 µM -0.191108190499131 0.419715019132274 no 2000 0.42422041540738 2914 5729214 SGTC_967 1306-0166 352 µM -0.1911771678579 0.419689156900074 no 2001 0.424193395550879 2852 4437607 SGTC_3264 9137442 49.47 µM -0.19130771892224 0.419640209296135 no 2002 0.424142256977255 2982 17015726 SGTC_2513 baicalein 25.65 µM -0.19183251492045 0.419443459708801 no 2003 0.423936700358482 2780 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2610 ononetin 44.17 µM -0.193000875766282 0.419005505680078 no 2004 0.423479141111137 2820 259632 SGTC_376 3970-0862 59.1 µM -0.193039848702696 0.418990898602609 no 2005 0.423463880111911 2861 3135186 SGTC_2299 7976368 114.88 µM -0.193206686471316 0.418928368979931 no 2006 0.423398551175903 2887 2979718 SGTC_1654 st012436 41.8 µM -0.193546541694194 0.418800999968422 no 2007 0.423265480030028 2771 4323132 SGTC_939 1165-0479 45.3 µM -0.193804739475067 0.418704239758155 no 2008 0.423164387905918 2796 1377347 SGTC_1548 st061468 90.8 µM -0.194459947471498 0.41845872114812 no 2009 0.42290787717409 2863 390799 SGTC_375 3970-0961 9.27 µM -0.195057913140347 0.418234680021633 no 2010 0.422673805053775 2802 2898222 SGTC_1332 1480-0653 17.5 µM -0.195968716024575 0.417893478477345 no 2011 0.422317326098601 2728 5749438 SGTC_170 4197-0004 226 µM -0.196824024108274 0.417573122440763 no 2012 0.421982625162099 2901 218692 SGTC_2069 5228469 200 µM -0.197934938086442 0.417157110789168 no 2013 0.421547984143039 2888 2835210 SGTC_908 3448-7491 47.7 µM -0.198310306925503 0.417016564756958 no 2014 0.421401144035968 2773 1203031 SGTC_1554 st069299 38.7 µM -0.19839051144957 0.416986535861224 no 2015 0.421369770336442 2825 24207999 SGTC_1103 duloxetine 36.1 µM -0.198433012375537 0.416970623540253 no 2016 0.421353145400786 2927 60835 A selective serotonin reuptake inhibitor. SGTC_1024 4507-0395 26 µM -0.198608748465463 0.416904829498736 no 2017 0.421284404829913 2932 4201836 SGTC_1078 idebenone 36.1 µM -0.198705194996038 0.416868721757651 no 2018 0.421246680021064 2829 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_352 k048-0007 5.11 µM -0.201407018877936 0.415857496510225 no 2019 0.42019016369744 2804 6811911 SGTC_2913 7966556 36.57 µM -0.201518037614178 0.415815956833767 no 2020 0.420146763374886 2783 2976516 SGTC_2669 eugenol 100 µM -0.203602077772369 0.415036350408665 no 2021 0.419332234663925 2801 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_180 1486-1293 102.781 µM -0.204727498248767 0.414615487300074 no 2022 0.418892517466346 2837 4140536 SGTC_1832 st054113 55 µM -0.206460214631604 0.413967711090395 no 2023 0.418215719671793 2801 1251267 SGTC_3034 9090421 49.47 µM -0.207578747939192 0.413549671463596 no 2024 0.417778949801681 2750 17173761 SGTC_2035 5154463 94.595 µM -0.207701609447574 0.413503759277727 no 2025 0.417730980463582 2884 2769623 SGTC_2803 7707263 71.43 µM -0.208391839027361 0.413245849001071 no 2026 0.417461513986137 2806 2199229 SGTC_2985 9022375 71.43 µM -0.21105391543607 0.412251492576381 no 2027 0.416422600164674 2982 4939335 SGTC_1238 0333-0287 48.8 µM -0.212213480893429 0.411818539657104 no 2028 0.415970245010612 2776 7226 SGTC_2459 5811157 9.22 µM -0.212441637862655 0.411733364136069 no 2029 0.41588125235705 2759 2870684 YBR192W RIM2 SGTC_1545 lovastatin 49.4 µM -0.213014079408015 0.411519678671653 no 2030 0.415657990459937 2826 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2602 kawain 100 µM -0.213053233853666 0.411505063751597 no 2031 0.415642720556926 2735 5369129 SGTC_2014 4013930 200 µM -0.213751295276282 0.411244523624929 no 2032 0.415370503900268 2805 64556 SGTC_2546 rhodinyl acetate 100 µM -0.214362011288881 0.411016615855054 no 2033 0.415132381843323 2799 6708682 SGTC_2421 5690543 90.72 µM -0.215062007063263 0.410755427494369 no 2034 0.414859487384613 2872 3397993 SGTC_2770 toltrazuril 17.5 µM -0.215103805569176 0.410739832532045 no 2035 0.414843193469476 2768 68591 Kills coccidiodes. SGTC_1478 0453-0656 35.7 µM -0.215884230617016 0.41044868300902 no 2036 0.414538994707189 2812 5258496 SGTC_443 clozapine 122 µM -0.215948562443881 0.410424685234516 no 2037 0.41451392134526 2760 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_466 geldanamycin 89.2 µM -0.216969208144463 0.410043997535753 no 2038 0.414116170836349 2853 5288382 HSP90 inhibitor. SGTC_2476 5806916 10.51 µM -0.218226758883894 0.409575063906361 no 2039 0.413626218451103 2811 2870194 SGTC_1178 0988-0033 191 µM -0.21849662784608 0.409474448114158 no 2040 0.413521092720797 2933 5392207 SGTC_961 1252-1571 372 µM -0.219075804077584 0.409258532802884 no 2041 0.413295499255618 2954 6813498 SGTC_2808 7946468 45.46 µM -0.21959428848712 0.409065266584182 no 2042 0.413093569986401 2871 2970879 SGTC_152 4469-0003 551.229 µM -0.221761398543425 0.408257711272114 no 2043 0.412249815370403 2802 697280 SGTC_2282 7944268 200 µM -0.222800020773581 0.40787081529643 no 2044 0.411845575919649 2990 2970414 SGTC_2847 9005661 71.43 µM -0.223076180933347 0.407767958293282 no 2045 0.411738108067637 2824 2991449 SGTC_2495 cafestol 54.53 µM -0.223125462668756 0.407749603773644 no 2046 0.411718930753746 3014 16667697 An anti-infammatory. SGTC_3084 9116877 49.47 µM -0.224530070589674 0.407226556017323 no 2047 0.411172435601446 2785 27241325 SGTC_2723 salbutamol 83.58 µM -0.225505728135304 0.406863338038598 no 2048 0.410792934859807 2898 9884233 β2-adrenoceptor agonist SGTC_18 0111-0177 500 nM -0.225731407570235 0.406779333450121 no 2049 0.410705164385677 2831 721752 SGTC_786 4544-0069 423 µM -0.226683689503946 0.406424913108239 no 2050 0.410334855440854 2925 748821 YLR208W SEC13 SGTC_349 k015-0014 24 µM -0.227778893832425 0.406017394684817 no 2051 0.409909067847134 2785 2196908 SGTC_2584 androsterone 48.74 µM -0.228770189252421 0.405648627855587 no 2052 0.409523768950622 2939 2754130 A steroid. SGTC_1012 4112-3522 18 µM -0.229210361994456 0.405484908226911 no 2053 0.409352709624729 2968 3112398 SGTC_1190 1486-1332 13 µM -0.229388118882677 0.405418797296713 no 2054 0.409283634877257 2806 4150046 SGTC_3148 9097893 49.47 µM -0.229470051979739 0.405388325837374 no 2055 0.40925179735184 2835 17174100 SGTC_2992 9074591 71.4286 µM -0.230613199336111 0.404963241687602 no 2056 0.408807656202133 2913 17741321 SGTC_2641 levomentholum 100 µM -0.231423483087188 0.40466200213585 no 2057 0.408492911701624 2842 16666 SGTC_103 0844-0104 51.839 µM -0.231441894690581 0.404655157901657 no 2058 0.408485760631544 2923 5375804 SGTC_3065 9113888 49.47 µM -0.231826675090414 0.404512128304982 no 2059 0.408336318831226 3013 16648368 SGTC_574 1315-0397 40 µM -0.232156945336307 0.404389371260353 no 2060 0.40820805842656 2808 6794277 SGTC_3233 9132340 49.47 µM -0.23531394768246 0.403216432253753 no 2061 0.406982535174344 2840 17682950 SGTC_1998 st075797 76.8 µM -0.23539531056571 0.403186214497729 no 2062 0.406950962729073 2808 24208315 SGTC_3036 9090181 49.47 µM -0.236103600536907 0.402923183688762 no 2063 0.406676140041338 2799 25236586 SGTC_834 0312-0008 75.7 µM -0.236126419914354 0.40291471020661 no 2064 0.406667286687245 2814 6385573 YIL048W NEO1 SGTC_69 0096-0274 206.684 µM -0.23630848668529 0.402847105283477 no 2065 0.406596650991941 3114 6741392 SGTC_1695 st026914 34.495 µM -0.237492112915684 0.402407672814194 no 2066 0.406137518593838 2797 3289191 SGTC_3286 9117135 37.221 µM -0.237640281845553 0.40235267236484 no 2067 0.406080052468035 2861 3438150 SGTC_863 0466-0191 129 µM -0.23935952229978 0.401714630265791 no 2068 0.405413407165013 2944 765160 YPR165W RHO1 SGTC_159 3970-0959 50 µM -0.239376603998986 0.401708292240829 no 2069 0.405406785011637 2915 6615653 SGTC_2910 7948405 25.97 µM -0.240221373597909 0.401394879669123 no 2070 0.405079322497643 2990 2971328 SGTC_897 1000-0139 31.4 µM -0.24022837008794 0.401392284210614 no 2071 0.405076610688285 2975 6151020 SGTC_1605 st000082 49.1 µM -0.241628943201349 0.400872807242203 no 2072 0.40453384653817 2942 1114022 SGTC_250 brefeldin a 552.239 µM -0.243651750076259 0.400122851332778 no 2073 0.403750272538156 2821 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1954 st077032 68.9 µM -0.243747765720951 0.400087262651348 no 2074 0.403713088565563 2906 698907 SGTC_896 0964-0007 44.5 µM -0.244106311607711 0.399954373152548 no 2075 0.403574242217783 2799 6756758 SGTC_1020 4335-0961 93.3 µM -0.244463591985462 0.399821964219015 no 2076 0.403435898023919 2806 669075 SGTC_2227 7312221 64.1025 µM -0.246372611143895 0.399114672855662 no 2077 0.402696903019261 2844 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1025 k007-0731 70 µM -0.246461685662828 0.399081678824052 no 2078 0.402662430099831 2845 6256118 SGTC_2301 7769476 200 µM -0.246734941484581 0.398980466821491 no 2079 0.402556681504791 2905 977820 SGTC_3349 9149703 23.001 µM -0.247507082298001 0.398694508116194 no 2080 0.402257905549112 2813 4910494 SGTC_510 ag-490 170 µM -0.249076052281396 0.398113615143542 no 2081 0.401650976655116 2906 5328779 SGTC_2223 6903751 107.57 µM -0.249758748377177 0.397860925227205 no 2082 0.401386961440025 2942 5598863 SGTC_1960 st011366 51.8 µM -0.249951354943502 0.397789642484066 no 2083 0.401312483923831 2819 3972846 SGTC_2283 7944793 200 µM -0.250059628488817 0.397749572475412 no 2084 0.401270618053463 2925 2970533 SGTC_1495 4469-0029 237 µM -0.250394691111571 0.397625578918121 no 2085 0.401141067381408 2835 793680 SGTC_1219 1469-0211 33.1 µM -0.250471274645457 0.397597239802493 no 2086 0.401111458178607 2954 6822282 SGTC_1423 4048-0112 5.59 µM -0.251218201117626 0.39732087408001 no 2087 0.400822706621844 2925 X1423 SGTC_2711 st079103 59.1 µM -0.251939314660104 0.397054108140106 no 2088 0.400543985389571 2907 54693780 SGTC_1652 st011932 78 µM -0.252746315237857 0.39675562659324 no 2089 0.400232127569995 2950 1551076 SGTC_873 0591-4978 488 µM -0.253637561119753 0.396426055914104 no 2090 0.399887787856894 3069 3305145 SGTC_1700 st030840 7.9285 µM -0.254220829975937 0.396210411017753 no 2091 0.399662479559437 2956 5499307 SGTC_2442 5158906 48.48 µM -0.254279395338412 0.396188760112107 no 2092 0.399639858453883 2989 1893835 SGTC_3153 9100258 49.47 µM -0.254702743911218 0.396032262795552 no 2093 0.399476348397325 2877 25236848 SGTC_2336 9001819 198.65 µM -0.254931272479285 0.395947790654549 no 2094 0.399388091059739 3078 2989602 SGTC_1975 st070967 30.8 µM -0.254957438991342 0.395938118909415 no 2095 0.399377985926038 2994 261391 SGTC_2682 pyrogallin 40.03 µM -0.255070851511736 0.395896199772107 no 2096 0.399334188407847 2884 822798 An ATP competetive kinase inhibitor. SGTC_1583 clindamycin 39.6 µM -0.256091414503777 0.395519037083221 no 2097 0.39894012561258 2847 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1156 4092-0367 4.88 µM -0.256337851240856 0.395427977745269 no 2098 0.398844986152954 2890 1357585 SGTC_1805 st050013 60.3 µM -0.256807782609446 0.395254352093937 no 2099 0.398663580933077 2913 4037144 SGTC_7 0192-1582 4.227 µM -0.256860026713365 0.395235050736456 no 2100 0.398643414758394 2909 252616 SGTC_874 0599-0792 117 µM -0.257645432961879 0.394944916808217 no 2101 0.398340281332752 3028 765305 SGTC_2124 5246320 200 µM -0.257945521531074 0.394834077603406 no 2102 0.398224476086216 2952 579342 SGTC_1901 st060216 58.6 µM -0.25857597676283 0.394601243563081 no 2103 0.397981210378684 2846 688792 SGTC_131 0141-0277 33.849 µM -0.258601806824067 0.394591705040041 no 2104 0.39797124450787 3043 1547771 SGTC_2103 5378138 10 µM -0.259042275300532 0.394429058606325 no 2105 0.397801311223605 2872 244142 SGTC_1979 st071809 45.3 µM -0.259367655197635 0.394308921349037 no 2106 0.397675791705463 2996 4976333 SGTC_627 1391-0720 175 µM -0.260518920012379 0.393883930405022 no 2107 0.397231761489183 2953 997839 SGTC_795 0685-0265 78 µM -0.261217730372786 0.393626025215852 no 2108 0.396962302902738 2862 302754 SGTC_701 4424-0219 185 µM -0.261421884779671 0.393550688138406 no 2109 0.396883591026572 3039 2911779 SGTC_2425 5628681 7.85 µM -0.261457390317318 0.393537586288436 no 2110 0.396869902270119 2950 5714958 SGTC_545 4218-0007 221 µM -0.261545752933241 0.393504980243496 no 2111 0.39683583561964 2990 2840508 SGTC_2398 5228213 48.84 µM -0.262843188363835 0.393026309150219 no 2112 0.39633572301588 3075 80771 YMR134W ERG29 SGTC_143 4032-1194 15.74 µM -0.265252039906202 0.392138025556046 no 2113 0.395407654051509 2804 1806963 SGTC_1950 st077106 7.18 µM -0.267457291802576 0.391325313419892 no 2114 0.394558546469353 2969 13831864 SGTC_3086 9117350 49.47 µM -0.268159719400413 0.391066543794967 no 2115 0.394288189530362 2850 2679265 SGTC_2784 7567673 72.73 µM -0.268643078840194 0.390888505412005 no 2116 0.394102179172263 2828 3471247 SGTC_1790 st045711 43.5 µM -0.268682828594631 0.390873865188189 no 2117 0.394086883418795 3041 585119 SGTC_2070 5230947 200 µM -0.26983693868688 0.390448862655933 no 2118 0.393642851781114 2983 2835538 SGTC_819 1013-0258 27.7 µM -0.270838998398948 0.390079958993111 no 2119 0.39325743203419 2897 5753198 SGTC_1936 st074407 74.3 µM -0.272316667325663 0.389536142655922 no 2120 0.392689270824447 2884 809813 SGTC_2407 paclitaxel 400 µM -0.274018116254559 0.388910237976673 no 2121 0.392035349777168 3116 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_248 streptozotocin 5.23457 mM -0.275687477977026 0.388296417166748 no 2122 0.391394057092119 2987 5300 DNA alkylating agent. SGTC_1651 st011928 86.1 µM -0.276267092946784 0.388083359106533 no 2123 0.391171464366161 3004 720198 SGTC_1138 3761-0006 1.03 µM -0.277325003809383 0.387694573289531 no 2124 0.390765280976798 2883 12061087 SGTC_570 0987-0065 62.6 µM -0.278384260949836 0.38730540549422 no 2125 0.390358700064341 2827 3104428 SGTC_1809 st050081 57.6 µM -0.279879236970893 0.386756348680474 no 2126 0.38978507868514 3065 5036894 SGTC_3250 9135583 49.47 µM -0.280207648620202 0.386635763915918 no 2127 0.389659099443108 3041 7699353 SGTC_2001 4023502 57.655 µM -0.280361768171846 0.386579178740184 no 2128 0.389599982928663 3020 108941 YCR052W RSC6 SGTC_2208 7283366 200 µM -0.28038371686905 0.386571120446177 no 2129 0.389591564149592 2990 898663 SGTC_791 1348-1292 225 µM -0.280593316228521 0.386494170130627 no 2130 0.389511171523425 2955 5437054 SGTC_1116 jasmonic acid  1.58368 µM -0.283993488800055 0.385246488610642 no 2131 0.388207685245047 3063 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2567 aureobasidin a 60 nM -0.285421556303386 0.38472281737561 no 2132 0.387660597273476 3155 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2747 doxorubicin 7.63 µM -0.285517046994882 0.384687808502737 no 2133 0.387624023044105 2937 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1996 st072960 66.8 µM -0.285569042510846 0.384668746260898 no 2134 0.387604108475892 3038 1719405 SGTC_476 mead acid 10 µM -0.286030426402985 0.384499609060875 no 2135 0.38742740887002 2900 5312531 An omega 9 fatty acid. SGTC_2858 9025781 8.96 µM -0.286533087822773 0.384315365092103 no 2136 0.387234927444809 3009 4894980 YPL153C RAD53 SGTC_681 1642-0006 26.6 µM -0.286976540909865 0.384152844859439 no 2137 0.387065141360886 2989 4446530 SGTC_105 0111-0055 734.78 µM -0.289911652118537 0.38307767661395 no 2138 0.38594191358595 3009 5179370 SGTC_1836 st055642 81 µM -0.290553693952812 0.382842608291299 no 2139 0.385696339810569 2927 8571 SGTC_1492 4158-0558 28.5 µM -0.291796490125152 0.382387710740531 no 2140 0.385221114495809 3022 3967268 SGTC_2822 7994718 71.43 µM -0.29189859200022 0.382350345852944 no 2141 0.385182080027336 2861 1018011 SGTC_2886 9058944 51.95 µM -0.292470555242296 0.382141052212737 no 2142 0.384963434839519 2958 4949929 SGTC_1718 roemerine 11.9335 µM -0.292678962778772 0.382064799973071 no 2143 0.384883775686673 3081 235224 An aporphine alkaloid with mutagenic activity. SGTC_709 3807-1509 243 µM -0.292870440415932 0.381994746084304 no 2144 0.384810591894576 2919 1886677 YPL242C IQG1 SGTC_1737 st035557 69.7 µM -0.292886615228084 0.381988828554567 no 2145 0.384804409981531 2851 5716916 SGTC_470 aa-861 153 µM -0.292988497965364 0.381951555548249 no 2146 0.384765471703504 2950 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1756 st041558 35.5 µM -0.293659342596984 0.38170615959919 no 2147 0.384509112512429 3120 3955792 SGTC_1622 st003707 19.4 µM -0.294094069902848 0.381547161089411 no 2148 0.384343011078118 3050 10140899 SGTC_884 0851-0618 334 µM -0.294171989564087 0.381518664622865 no 2149 0.384313241629343 3059 9642473 SGTC_1990 st072050 59.8 µM -0.294196449169532 0.381509719486321 no 2150 0.384303896901765 2904 17233948 SGTC_872 0588-0139 234 µM -0.294197098479278 0.381509482027738 no 2151 0.38430364883561 2915 2047100 SGTC_2099 5377090 177.372 µM -0.294814056957999 0.381283874768483 no 2152 0.384067963778297 3009 2243829 SGTC_2395 5646831 180.19 µM -0.296172554379548 0.380787246390944 no 2153 0.383549153750744 3098 6808628 SGTC_1874 staurosporine 7.6 µM -0.296535626141796 0.380654550802494 no 2154 0.383410531987658 3049 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1668 st014914 51.6 µM -0.296724482244376 0.380585533160788 no 2155 0.383338432125391 2995 2839556 SGTC_3318 9139014 38.6185 µM -0.29881714293887 0.37982102316078 no 2156 0.382539785028697 2917 16643984 SGTC_1961 st076550 68.7 µM -0.299737952171783 0.379484773243002 no 2157 0.382188523587188 3048 1579337 SGTC_1507 4075-3230 155 µM -0.300508445166305 0.37920348399813 no 2158 0.381894677816647 2899 659771 SGTC_399 oxolinic acid 75 µM -0.301271896129592 0.378924828704655 no 2159 0.381603584790462 2931 4628 A DNA gyrase inhibitor. SGTC_2186 6124449 200 µM -0.302950791183047 0.378312262977012 no 2160 0.380963681614197 3091 3834182 YLR033W RSC58 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.303190120670499 0.378224965499618 no 2161 0.380872488734082 3204 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_324 1315-0088 19.6 µM -0.304045027319456 0.377913181777219 no 2162 0.380546793557104 3012 6787421 SGTC_2755 lomerizine 42.69 µM -0.304386963810962 0.377788500080485 no 2163 0.380416549142335 2975 3949 A calcium channel blocker. SGTC_1803 st050068 52.4 µM -0.304658444278383 0.377689518116884 no 2164 0.380313151245792 3006 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2838 9002687 71.43 µM -0.305398865537621 0.377419600859932 no 2165 0.380031192857899 2912 6457060 SGTC_431 k089-0097 107 µM -0.305586626232144 0.377351163048894 no 2166 0.379959702198235 3058 5499420 SGTC_2813 7971799 71.43 µM -0.307647868133515 0.376600104602452 no 2167 0.379175146017412 3051 2234054 SGTC_755 1995-0008 37.3 µM -0.308892536023252 0.376146808589413 no 2168 0.378701637373548 3046 689533 SGTC_2676 harmalol 100 µM -0.30960829067736 0.375886214975895 no 2169 0.378429425425182 3062 5459187 A monoamine oxidase inhibitor SGTC_218 alverine citrate 93.75 µM -0.30989148540769 0.375783124400982 no 2170 0.378321738979764 3081 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2094 5332512 191.667 µM -0.310115670979686 0.375701521049755 no 2171 0.378236497811651 3107 755774 SGTC_2441 5730946 39.09 µM -0.310379128700467 0.37560562977684 no 2172 0.378136331928587 3080 1774275 SGTC_671 0560-0003 407 µM -0.310807458515874 0.375449746056211 no 2173 0.377973499625069 2984 3238678 SGTC_2107 5363541 170.161 µM -0.311329913636462 0.375259634478823 no 2174 0.377774914335279 3048 244052 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.311835800083932 0.37507558079716 no 2175 0.377582657579029 3084 16725076 SGTC_1292 0kpi-0043 232 µM -0.312177332278071 0.374951339233949 no 2176 0.377452879051783 2993 3333905 SGTC_734 2023-0417 80 µM -0.312279616342882 0.374914133166146 no 2177 0.377414014908932 3059 3935732 SGTC_608 k048-0125 159 µM -0.313616899363788 0.37442780056121 no 2178 0.376906011411744 3080 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_3201 9113999 49.47 µM -0.314052235557672 0.374269523959754 no 2179 0.376740682981158 3139 16649224 SGTC_495 decylubiquinone 155 µM -0.315247251820405 0.373835156980677 no 2180 0.376286965708849 3022 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1353 1498-1206 8.11 µM -0.31610839333002 0.373522246754617 no 2181 0.3759601180978 2982 6756808 SGTC_1881 5652484 16 µM -0.316179814925925 0.37349629825977 no 2182 0.375933013911104 3107 2255129 SGTC_1159 4092-0538 61.2 µM -0.316529461784847 0.373369274797175 no 2183 0.375800333275545 2979 717301 SGTC_2341 7987486 176.74 µM -0.316684691548128 0.373312885672564 no 2184 0.375741432879865 3123 1258686 SGTC_2455 5377712 9.75 µM -0.316686450602796 0.37331224668982 no 2185 0.375740765440588 3035 2243908 SGTC_625 k213-0058 121 µM -0.316850817288791 0.373252541455268 no 2186 0.375678401320949 3020 3655420 SGTC_1436 4092-1007 8.32 µM -0.317486295144079 0.373021736490522 no 2187 0.375437318447157 2981 2881121 SGTC_3051 9093778 49.47 µM -0.318175400474539 0.372771505573908 no 2188 0.375175945746966 3008 17217378 SGTC_2448 5185112 27.17 µM -0.31820969198462 0.372759054893235 no 2189 0.375162940719348 3096 5718189 SGTC_2568 diosmetin 100 µM -0.320077837765104 0.372080963240856 no 2190 0.374454662755075 3145 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_439 amiodarone 34.4 µM -0.32011330912838 0.372068091824844 no 2191 0.374441218436832 2986 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2445 5742597 35.57 µM -0.320238639141835 0.372022614741927 no 2192 0.374393717211604 2973 1774255 SGTC_3249 9135183 49.47 µM -0.320885410506136 0.371787956530698 no 2193 0.374148615248692 3141 4902779 SGTC_2517 totarol 10 µM -0.321046058575196 0.371729678416988 no 2194 0.374087743569394 3070 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1148 3909-7663 27.7 µM -0.321651350402229 0.371510123814662 no 2195 0.373858418696156 3090 4084526 SGTC_854 0422-0053 192 µM -0.321683030502087 0.371498633794328 no 2196 0.373846417392341 2986 3596728 SGTC_3012 9080433 71.4286 µM -0.32294593543097 0.371040685564017 no 2197 0.373368093577638 3081 17688859 SGTC_1806 st050005 60.3 µM -0.325586916959507 0.370083616880257 no 2198 0.372368456023607 2985 5194765 SGTC_1013 4112-3890 241 µM -0.325806568883182 0.370004053069112 no 2199 0.372285354219714 2948 705171 SGTC_732 3970-1727 52.7 µM -0.32600455202571 0.369932343038073 no 2200 0.372210455549479 3090 1275699 SGTC_1240 0356-0016 42.1 µM -0.328693438811649 0.368958869679498 no 2201 0.371193707050858 3009 4305613 SGTC_610 4215-0184 155 µM -0.329090178958215 0.368815306496807 no 2202 0.371043763623248 3036 5605015 SGTC_1248 0469-0687 58.6 µM -0.329696938403605 0.368595781776768 no 2203 0.370814483659368 3087 4017482 SGTC_2763 lisinopril 49.32 µM -0.331631154660525 0.367896271548637 no 2204 0.370083895826685 3003 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_67 0335-0847 266 µM -0.332786972804313 0.367478478222197 no 2205 0.369647546248003 3298 4552207 YOR254C SEC63 SGTC_361 000s-0510 1.45 µM -0.333050416530971 0.367383273203305 no 2206 0.369548113270954 3075 660 SGTC_1000 4048-0884 8.67 µM -0.333077946428415 0.367373324739032 no 2207 0.369537723017632 3111 13040088 SGTC_196 k015-0023 18.111 µM -0.333179145883258 0.367336755111449 no 2208 0.369499529434442 2992 5211998 SGTC_2026 5148700 152 µM -0.334145869802291 0.366987478606832 no 2209 0.369134744102186 2968 79838 SGTC_2048 5246248 200 µM -0.33490391605145 0.366713674139225 no 2210 0.368848783973177 3115 677046 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.336209808862762 0.366242147909113 no 2211 0.368356328310173 3013 2724278 An inhibitor of dopamine biosynthesis. SGTC_1392 3455-1037 33.9 µM -0.336620236696566 0.366093994033665 no 2212 0.368201599489674 3152 981132 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.337212988680494 0.365880061073948 no 2213 0.367978173297357 3056 66535 A nucleotide analog. SGTC_594 1487-1584 10.8 µM -0.338513524098879 0.365410824790899 no 2214 0.367488118638628 3009 5013332 SGTC_2059 5238311 157 µM -0.340852037304569 0.364567590647287 no 2215 0.366607486759996 2973 703021 SGTC_1102 cgs 12066b 26.1 µM -0.341051108203702 0.364495838742026 no 2216 0.36653255345013 3045 6438352 A 5-HT1B full agonist. SGTC_2852 9023854 51.95 µM -0.341627718359219 0.364288035679683 no 2217 0.366315537347852 3162 19798528 SGTC_503 tyrphostin 8 294 µM -0.341645520822074 0.364281620529971 no 2218 0.366308837797 3112 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.342875810461063 0.363838375629354 no 2219 0.365845945165867 3078 688801 SGTC_985 1493-0307 8.71 µM -0.343276165853276 0.363694176092555 no 2220 0.36569535477205 3154 3278274 SGTC_759 3486-0358 89.3 µM -0.343321701387113 0.363677776379642 no 2221 0.365678228265185 3188 875103 SGTC_2970 9090938 41.86 µM -0.345602792936095 0.362856556954056 no 2222 0.364820623357577 3217 17217104 SGTC_2731 amoxapine 43.43 µM -0.349499909608413 0.361455009738033 no 2223 0.363357019332247 3082 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2377 9073351 62.6 µM -0.349627694486411 0.361409084916646 no 2224 0.36330906197383 2999 7337946 YHR072W ERG7 SGTC_2802 7925815 54.55 µM -0.355097088354165 0.359445309959062 no 2225 0.361258428929299 3001 1262923 SGTC_571 k831-0106 44.2 µM -0.355502760548628 0.359299801193365 no 2226 0.361106488600006 3162 4783639 SGTC_2987 9018338 71.43 µM -0.356996808805426 0.358764083723083 no 2227 0.360547097373649 3161 5055682 SGTC_1915 st067105 30.6 µM -0.357429183201559 0.358609099993713 no 2228 0.3603852663433 3049 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_450 aminopyrene 156 nM -0.359002450230539 0.358045362251599 no 2229 0.35979662814083 3151 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_172 1112-0046 2.638 µM -0.359080434338742 0.358017426790922 no 2230 0.359767459005154 3035 2802135 YIL048W NEO1 SGTC_2841 9004761 38.96 µM -0.359998823260063 0.357688498819231 no 2231 0.359424006777644 3061 2991039 SGTC_1903 st060211 78.3 µM -0.360791157152431 0.357404803304326 no 2232 0.359127786886564 3200 688960 SGTC_2272 7805186 180 µM -0.361170910047121 0.357268860525866 no 2233 0.358985843460201 3172 2956062 YPR165W RHO1 SGTC_422 cantharidin 155 µM -0.362098764351865 0.356936786309624 no 2234 0.358639113494856 2976 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2812 7970281 58.44 µM -0.362179476884587 0.356907904834924 no 2235 0.358608957523497 3180 2233435 SGTC_1142 3253-1408 9.78 µM -0.362419886242849 0.356821883689251 no 2236 0.35851914054165 3163 256655 SGTC_3110 9122132 49.47 µM -0.36570835436867 0.355645965703325 no 2237 0.357291355735376 3215 918317 SGTC_2140 5586273 200 µM -0.365981365514899 0.355548401642499 no 2238 0.357189490282165 3102 854421 SGTC_2611 pyromycin 23.93 µM -0.366897560067223 0.35522105688442 no 2239 0.356847715758516 3063 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1826 st055655 41.6 µM -0.367843308665001 0.354883264864145 no 2240 0.356495036969204 3124 676168 SGTC_1287 0971-0001 34.6 µM -0.368525776187805 0.354639579490517 no 2241 0.356240614420681 3089 4665869 SGTC_347 4534-1311 26.2 µM -0.368718756141076 0.354570683855627 no 2242 0.356168683473467 3022 2862016 SGTC_2635 hydroquinidine 100 µM -0.369134971151392 0.354422107431148 no 2243 0.356013561780676 3018 442912 An experimental heart treatment. SGTC_1797 st048695 56.8 µM -0.370695221634686 0.353865341565445 no 2244 0.355432274877895 3168 592262 YIL048W NEO1 SGTC_1993 st073995 70.8 µM -0.371635766897944 0.353529864552678 no 2245 0.355082027640616 3060 3098394 SGTC_1312 1218-2183 165 µM -0.37257056222744 0.353196551142405 no 2246 0.354734042889813 3110 6744073 SGTC_1241 0364-0022 50.8 µM -0.373644897350017 0.352813622064564 no 2247 0.354334263050056 3084 4563895 SGTC_1775 st081588 35.1725 µM -0.373946167757706 0.352706265928664 no 2248 0.354222183583857 3082 1426443 YGL099W LSG1 SGTC_966 1300-0360 30.2 µM -0.375657831068801 0.352096546490853 no 2249 0.353585645680572 3066 70588 SGTC_2865 9030313 51.95 µM -0.376242242204889 0.351888457669472 no 2250 0.353368406931508 3029 42562754 SGTC_894 0960-0238 55.9 µM -0.376416882113448 0.351826282974917 no 2251 0.353303498619819 3189 6741907 YDL195W SEC31 SGTC_2278 7948257 134.34 µM -0.377898767333686 0.351298866944054 no 2252 0.352752899095068 3190 1247028 SGTC_1638 st008370 60.6 µM -0.379548978444201 0.350711879095263 no 2253 0.352140120316145 3110 24207134 SGTC_2198 6589944 200 µM -0.383254263643498 0.349395191309052 no 2254 0.35076562363731 3122 5290268 SGTC_2727 riluzole 51.77 µM -0.385579730291879 0.348569750978179 no 2255 0.349903973713028 3126 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_3152 9099253 49.47 µM -0.386089752038575 0.348388810925945 no 2256 0.349715099623663 3131 25236131 SGTC_2195 6536160 144.242 µM -0.387396448211465 0.347925392741874 no 2257 0.349231366421902 3068 3834386 SGTC_601 0986-0029 62.9 µM -0.388109637597879 0.347672556743471 no 2258 0.348967450060023 3110 24747981 SGTC_1169 aniline yellow 25.8 µM -0.389508413678854 0.347176867094965 no 2259 0.348450043952596 3097 6051 A DNA damaging agent. SGTC_206 4546-0025 72.014 µM -0.391831402765277 0.346354238230529 no 2260 0.347591395297285 3169 6620745 YIL048W NEO1 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.391905737781825 0.346327926270049 no 2261 0.347563931652971 3049 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_300 r073-0011 5.04 µM -0.393083529360719 0.345911128846968 no 2262 0.347128894333267 3205 2735780 SGTC_2556 citropten 84.59 µM -0.393307665408491 0.345831832603374 no 2263 0.34704612866841 3120 2775 A potential DNA crosslinker. SGTC_1121 fusaric acid 630.51 nM -0.3943932610257 0.345447859585646 no 2264 0.346645359186904 3093 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_899 1083-0020 478 µM -0.395959836704654 0.344894045200141 no 2265 0.346067328737334 3257 767123 SGTC_3130 9127414 49.47 µM -0.396173794343333 0.344818432846692 no 2266 0.345988411075843 3181 1494646 SGTC_509 pifithrin 175 µM -0.396298117788043 0.344774499948434 no 2267 0.34594255780223 3209 4817 A p53 inhibitor. SGTC_1398 3558-0053 112 µM -0.396575583050699 0.344676457984982 no 2268 0.345840230540898 3026 4532369 SGTC_447 ml7 120 µM -0.396604679250809 0.344666177487452 no 2269 0.345829500716555 3181 4216 Selective myosin light chain kinase inhibitor. SGTC_958 1222-0007 33 µM -0.397553446076325 0.344331014650015 no 2270 0.345479691256235 3259 7312461 SGTC_2989 9073649 71.4286 µM -0.39772222470094 0.344271404448541 no 2271 0.345417476545148 3209 21367202 SGTC_2343 7990716 14.84 µM -0.398175472741626 0.344111342856905 no 2272 0.34525042217264 3070 6456862 SGTC_367 0335-0881 7.1 µM -0.398228979962496 0.344092448972958 no 2273 0.345230702917542 3263 23828853 SGTC_668 1682-0499 62.6 µM -0.400895974036491 0.343151203266493 no 2274 0.344248357069827 3160 682214 SGTC_1469 k284-2957 126 µM -0.404462496712139 0.341894012629639 no 2275 0.342936325411435 3156 23884841 SGTC_2891 9063876 19.48 µM -0.40627708154726 0.341255047059041 no 2276 0.342269511509943 3201 6472478 SGTC_697 0508-1955 564 µM -0.406506319263478 0.341174358435381 no 2277 0.342185307387084 3278 6243113 SGTC_2254 7938975 95.19 µM -0.406810091206831 0.341067445944114 no 2278 0.342073737269649 3295 2969277 SGTC_2391 6285546 200 µM -0.40712681668666 0.340955988044695 no 2279 0.341957424226223 3093 846083 SGTC_3031 9088762 49.47 µM -0.407564492730103 0.340801989643916 no 2280 0.341796718447979 3064 205253 SGTC_1623 st003709 20.3 µM -0.410106381339428 0.339908139125506 no 2281 0.340863955898783 3111 16192618 SGTC_3049 9092223 49.47 µM -0.412447009073813 0.33908585668165 no 2282 0.340005906688867 3207 8623917 SGTC_705 1124-0212 310 µM -0.412788412500024 0.338965982667951 no 2283 0.339880820923969 3286 9554485 SGTC_211 3455-0679 143.504 µM -0.414086881703068 0.338510211489151 no 2284 0.339405239846192 3231 748649 SGTC_3095 9117207 49.47 µM -0.414100133702632 0.338505561168419 no 2285 0.339400387447289 3201 17015229 SGTC_761 k216-0224 480 µM -0.414285488816844 0.338440519925538 no 2286 0.339332519956136 3299 1340404 SGTC_21 0849-0113 22.993 µM -0.418244398571147 0.337052489132667 no 2287 0.337884218662509 3168 1560156 SGTC_2090 5301565 104.445 µM -0.41832597547828 0.337023910741152 no 2288 0.337854400239066 3141 2056344 SGTC_2619 obliquin 87.91 µM -0.420478291252548 0.336270241983786 no 2289 0.337068042459803 3114 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3352 9151559 45.5865 µM -0.422649086245137 0.335510768368245 no 2290 0.33627565374813 3186 17159339 SGTC_2652 actinonin 100 µM -0.422843870032759 0.335442654166047 no 2291 0.336204588791913 3115 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2946 9065502 71.43 µM -0.423498649124576 0.335213723251865 no 2292 0.335965741975959 3157 16489101 SGTC_1876 myriocin 605 nM -0.423827954296424 0.335098611153404 no 2293 0.335845644818424 3299 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2514 salinomycin 42.74 µM -0.424321617210545 0.334926075083083 no 2294 0.335665638010728 3304 23682228 A polyether potassium ionophore. SGTC_3225 9130819 49.47 µM -0.424430500500854 0.334888024866315 no 2295 0.335625940418996 3269 4547121 SGTC_974 1326-0144 138 µM -0.424985313111919 0.334694167082559 no 2296 0.335423690638173 3172 5411856 SGTC_377 3970-0964 33.1 µM -0.425196121480431 0.334620519807505 no 2297 0.335346855664642 3158 16481235 SGTC_3042 9091578 49.47 µM -0.42542734648391 0.334539747164701 no 2298 0.335262587200268 3255 25236497 SGTC_909 3448-9333 149 µM -0.425517396708009 0.334508292454104 no 2299 0.335229771218123 3130 3344074 SGTC_1290 0986-0249 10.2 µM -0.42622921085153 0.334259695348701 no 2300 0.334970417131711 3192 53329 SGTC_544 k015-0020 52.4 µM -0.426304593689406 0.334233372568713 no 2301 0.334942955512484 3190 3008304 SGTC_2497 7-hydroxyflavone 100 µM -0.427260673867746 0.333899591647566 no 2302 0.334594736542674 3284 5281894 SGTC_1556 plumbagin 1.48 µM -0.42808936331946 0.333610390870107 no 2303 0.334293030262559 3229 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1981 st071826 47 µM -0.429835569316277 0.333001313672192 no 2304 0.333657628385513 3223 11838600 SGTC_72 0744-0168 198.391 µM -0.430248921853327 0.332857200567626 no 2305 0.333507289178072 3066 677577 SGTC_1044 1222-0021 1.78 µM -0.431669499111357 0.332362112392945 no 2306 0.332990819249404 3217 4306703 SGTC_1036 k216-0215 33.5 µM -0.43363104404676 0.331678971175459 no 2307 0.332278193859979 3144 622330 SGTC_2129 girgensonine 121.053 µM -0.436326249084753 0.330741233066559 no 2308 0.331300019857119 3205 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_342 k048-0088 23.3 µM -0.436973645627277 0.330516143340892 no 2309 0.331065230475154 3146 6820570 SGTC_521 r062-0005 13.8 µM -0.439992793988251 0.329467242863808 no 2310 0.329971163212948 3193 2832033 SGTC_1710 st031758 61.5 µM -0.440703848612463 0.329220405808433 no 2311 0.329713705011634 3333 5394341 SGTC_1457 k015-0032 57.3 µM -0.440740835204634 0.329207568237518 no 2312 0.329700315136309 3223 4302660 SGTC_922 1866-0035 480 µM -0.441686955805403 0.328879250430505 no 2313 0.329357875077418 3167 3156169 SGTC_1656 st012921 11 µM -0.443088855773447 0.328393013200932 no 2314 0.328850732801712 3258 6732821 SGTC_1084 voriconazole 435 nM -0.444574255749187 0.32787813167001 no 2315 0.328313727736479 3291 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_192 3455-0609 60.9 µM -0.445304644860919 0.327625078062525 no 2316 0.328049805813357 3309 3769639 SGTC_2110 5483698 200 µM -0.445806430588401 0.327451273184375 no 2317 0.327868538142989 3200 2848765 YHR062C RPP1 SGTC_2376 9072922 81.32 µM -0.449351677713818 0.326224363552698 no 2318 0.326588992035293 3318 17087968 SGTC_1594 piperine 70.1 µM -0.450288438640214 0.32590049030375 no 2319 0.326251237131066 3184 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_277 nystatin 15.5 µM -0.452567693066509 0.325113015759951 no 2320 0.325430033335107 3147 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1058 3448-5425 97.3 µM -0.453191704907745 0.324897557768056 no 2321 0.32520535252179 3250 7279705 SGTC_1509 1326-1131 80 µM -0.453534111069177 0.32477935709312 no 2322 0.32508209323754 3285 768313 SGTC_1309 pyrazolanthrone 13.4 µM -0.454171239726095 0.324559463391487 no 2323 0.324852790773381 3298 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_623 k072-0108 16.9 µM -0.454375438348936 0.324489000779031 no 2324 0.324779313768855 3252 5382803 SGTC_676 falcarinol 140 µM -0.458506209395077 0.323064951779477 no 2325 0.323294401229255 3384 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1754 st042065 16.137 µM -0.459729695775524 0.32264366113821 no 2326 0.322855125842288 3300 1126236 YIL048W NEO1 SGTC_753 1322-0200 289 µM -0.461324255641951 0.322094938082213 no 2327 0.322282992621939 3342 5403907 SGTC_1944 st076371 56.9 µM -0.462334002052018 0.3217476625126 no 2328 0.321920909841687 3190 24208455 SGTC_1373 2887-0003 58.5 µM -0.462963305591399 0.321531308923558 no 2329 0.321695334710326 3232 776948 SGTC_2551 apiole 73.87 µM -0.463469414777724 0.321357353269788 no 2330 0.321513966515697 3224 10659 A possible DNA adduct former. SGTC_2540 epiandrosterone 100 µM -0.463579343273516 0.321319574736256 no 2331 0.321474578399258 3298 441302 A steroid. SGTC_3211 9128781 49.47 µM -0.464831825333962 0.320889271577189 no 2332 0.321025947493672 3246 17194361 SGTC_2414 st077232 92.9 µM -0.46742380760603 0.319999533553123 no 2333 0.320098346297411 3157 729801 SGTC_87 0100-0052 35.5 µM -0.467560961576405 0.319952482100841 no 2334 0.320049293801613 3352 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_984 1492-0255 2.91 µM -0.469608163267614 0.319250522468774 no 2335 0.319317495672962 3305 1585198 SGTC_303 1348-1668 34.2 µM -0.471713127956709 0.31852943167475 no 2336 0.318565782695182 3272 5380509 SGTC_1368 1852-0141 284 µM -0.475470054102838 0.317244141934065 no 2337 0.317225986349234 3324 2838987 SGTC_2317 5986382 200 µM -0.478945729392478 0.316057030709607 no 2338 0.315988618798289 3288 877883 SGTC_955 1216-0110 33 µM -0.482801765798084 0.314742223849397 no 2339 0.314618248453538 3287 3619719 SGTC_407 eburnamonine 100 µM -0.485366022927661 0.313869176750476 no 2340 0.313708364792623 3250 3195 SGTC_990 3985-0011 41.3 µM -0.487923373456598 0.312999517730957 no 2341 0.312802058989984 3274 5399565 YGL099W LSG1 SGTC_2009 4012297 12.05 µM -0.488068434556244 0.312950218998283 no 2342 0.312750684255968 3317 45595307 SGTC_1338 1486-1223 76 µM -0.488297763200626 0.312872288927556 no 2343 0.31266947280986 3303 3444526 SGTC_1380 2291-0730 164 µM -0.488430751227745 0.312827100992034 no 2344 0.312622382335161 3290 2999191 SGTC_1455 4262-0120 131 µM -0.488711729117152 0.312731636903816 no 2345 0.312522899360879 3428 1529587 SGTC_1186 1319-0216 26 µM -0.489300275753572 0.312531715021553 no 2346 0.312314562938074 3412 4565136 SGTC_1065 prochlorperazine maleate 2.48 µM -0.489974043000323 0.312302912485692 no 2347 0.312076133383381 3374 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_430 0958-0115 16.4 µM -0.490343864506401 0.312177356696521 no 2348 0.311945296152835 3241 6833180 SGTC_227 fluconazole 33.516 µM -0.490472413233607 0.312133719028993 no 2349 0.311899823121722 3301 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1982 st072467 71.9 µM -0.491337702104497 0.311840053200764 no 2350 0.311593809088451 3208 3163533 SGTC_836 0330-0104 1.35 µM -0.491596025731364 0.311752405278467 no 2351 0.311502476762121 3315 46494820 SGTC_650 1328-0195 38 µM -0.494078907517982 0.310910520142659 no 2352 0.310625226719237 3351 2780821 SGTC_2860 9025725 38.96 µM -0.494102254067518 0.310902608578425 no 2353 0.310616983030405 3222 40546248 SGTC_3037 9091026 49.47 µM -0.495304830933551 0.310495203505435 no 2354 0.310192480678734 3361 25236398 YIL048W NEO1 SGTC_1624 st003710 6.25 µM -0.495605284982967 0.310393452919186 no 2355 0.310086461666868 3351 24207033 SGTC_2738 aclarubicin 5.55 µM -0.496405707210023 0.310122455904511 no 2356 0.309804099622484 3273 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_150 3970-0969 77.2 µM -0.497980376947337 0.309589624795142 no 2357 0.309248936620913 3373 6615640 SGTC_1361 1608-0041 5.61 µM -0.498332728172038 0.309470452169169 no 2358 0.309124771790173 3299 X1361 SGTC_2050 5263056 171 µM -0.501807484931522 0.308296290567106 no 2359 0.307901473762117 3393 763468 YGL055W OLE1 SGTC_637 1181-0519 7.26 µM -0.502737316675898 0.307982421054211 no 2360 0.307574484835323 3361 6252091 YGR060W ERG25 SGTC_3006 9075424 71.4286 µM -0.504311918382145 0.307451226392059 no 2361 0.30702110174893 3285 7465181 SGTC_1114 scopoletin 1.73284 µM -0.504919342173293 0.307246418713145 no 2362 0.306807744132366 3403 5280460 A coumarin with genotoxic properties. SGTC_828 2074-0507 139 µM -0.505655344874147 0.306998338069877 no 2363 0.306549310843993 3398 X828 SGTC_61 0978-8327 98.565 µM -0.505667649351289 0.306994191413532 no 2364 0.306544991178861 3387 6150059 YHR072W ERG7 SGTC_1948 st076329 66.6 µM -0.506212389008525 0.306810636791091 no 2365 0.306353779363701 3316 24208413 SGTC_886 0866-0150 153 µM -0.507506969406782 0.306374611367956 no 2366 0.30589957376662 3425 271463 SGTC_3319 9138450 16.7555 µM -0.510206972514114 0.305466110153367 no 2367 0.304953233933563 3276 2029690 SGTC_1406 3909-7906 11.9 µM -0.511473809375081 0.305040255014973 no 2368 0.304509661603877 3369 X1406 SGTC_205 1486-1330 71.903 µM -0.512422480137999 0.304721526145695 no 2369 0.304177680584896 3348 4118834 SGTC_2815 7968870 71.43 µM -0.514998385094764 0.303856836474039 no 2370 0.303277074242843 3339 2977326 YHR190W ERG9 SGTC_2922 7999257 32.47 µM -0.515424052612242 0.303714052202266 no 2371 0.303128364149651 3387 2988377 SGTC_593 1203-0218 61.7 µM -0.515534110717034 0.303677139608219 no 2372 0.303089919844429 3420 3666956 SGTC_529 4076-0302 30.3 µM -0.516567372699238 0.303330689631983 no 2373 0.302729098371896 3301 5816522 SGTC_2473 5854593 8.94 µM -0.516961648959892 0.303198536436904 no 2374 0.302591465400433 3253 2872951 SGTC_147 4466-0538 29.23 µM -0.518437015674552 0.302704252807257 no 2375 0.302076697068243 3483 6742687 YHR072W ERG7 SGTC_2041 5107442 45.335 µM -0.518680242869699 0.302622800470622 no 2376 0.301991870745444 3447 793005 SGTC_2207 7258803 200 µM -0.518951465395318 0.302531984594155 no 2377 0.301897293573933 3386 3666799 SGTC_335 4077-0256 27.6 µM -0.519533471783222 0.302337147410963 no 2378 0.301694388853914 3373 3121989 SGTC_38 0929-0051 58.268 µM -0.520901025129682 0.301879555829432 no 2379 0.30121786062626 3363 1379719 SGTC_1659 st012954 42.1 µM -0.521240413874133 0.301766042530482 no 2380 0.301099652091896 3406 24207262 SGTC_2591 skatole 100 µM -0.522938291011169 0.301198452186007 no 2381 0.300508598472264 3401 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.524032545415842 0.300832904419218 no 2382 0.300127951851418 3316 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1236 0330-0013 258 µM -0.525110434720441 0.300473019379959 no 2383 0.299753211320885 3326 4617066 SGTC_1135 dihydrocapsaicin 536.708 nM -0.525720559332959 0.300269397565796 no 2384 0.299541188491971 3352 107982 A Capsaicinoid. SGTC_2536 dehydroabietamide 32.04 µM -0.527613530766793 0.299638038265361 no 2385 0.298883799884498 3443 3983547 SGTC_2639 lactacystin 53 µM -0.528958569060819 0.29918979594649 no 2386 0.298417095475443 3455 3870 A proteasome inhibitor. SGTC_3232 9132874 49.47 µM -0.531155861169838 0.298458190165603 no 2387 0.297655388436694 3350 3784940 SGTC_1709 st033179 39.1045 µM -0.532279670974875 0.298084323711504 no 2388 0.297266154967598 3365 573381 SGTC_2040 5100729 123 µM -0.532542371151097 0.297996960002626 no 2389 0.297175201858911 3334 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_81 0411-0046 9.971 µM -0.533977463541084 0.297519911070241 no 2390 0.296678563136519 3357 12925265 SGTC_3193 9111931 49.47 µM -0.534102832243625 0.297478252962819 no 2391 0.296635195171186 3345 17087244 SGTC_2358 9037157 4 µM -0.534393553402366 0.297381661007619 no 2392 0.296534639100528 3388 2388925 SGTC_419 nsc-638432 893 µM -0.536222780364977 0.29677423023255 no 2393 0.295902295649097 3359 368090 SGTC_2726 cimetidine 79.27 µM -0.540367448940497 0.295400017452189 no 2394 0.294471825778784 3385 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_215 1287-0124 461.5 µM -0.541317765758778 0.295085341956455 no 2395 0.294144288623746 3379 5560863 SGTC_1629 st005085 44.9 µM -0.541562647006043 0.295004280203048 no 2396 0.294059914893134 3332 24207091 SGTC_969 1313-0238 134 µM -0.541606313362773 0.294989826636088 no 2397 0.294044870843665 3344 5212874 SGTC_2752 diclazuril 33.15 µM -0.541639731666214 0.294978765395833 no 2398 0.294033357721133 3411 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1002 4049-0206 172 µM -0.542598713793263 0.294661430029407 no 2399 0.293703062372004 3381 4662749 SGTC_3068 9116768 49.47 µM -0.542789907309845 0.294598181295167 no 2400 0.293637231493968 3427 41904888 SGTC_3293 9120939 62.045 µM -0.542894063544581 0.294563728003024 no 2401 0.29360137176949 3445 934087 SGTC_39 0986-0283 58.349 µM -0.543827202441496 0.294255142878235 no 2402 0.293280193889301 3495 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1454 4239-0054 42.6 µM -0.544376386052398 0.294073599988929 no 2403 0.29309124606626 3531 1340767 SGTC_1956 st077085 54 µM -0.544660322394927 0.293979759839667 no 2404 0.292993579292936 3395 24208685 SGTC_286 k060-0067 22.9 µM -0.545060174701835 0.293847633278502 no 2405 0.292856066030975 3369 5985051 SGTC_2702 st077768 96.8 µM -0.549477056811716 0.292389956895956 no 2406 0.291339052726385 3397 6484119 SGTC_3237 9133362 49.47 µM -0.550522363658892 0.292045473339499 no 2407 0.290980571120789 3424 43845137 SGTC_11 0438-0307 1.3 µM -0.552592111350718 0.291363940662843 no 2408 0.290271372492307 3458 4011476 SGTC_1662 st014054 52 µM -0.552681007111818 0.291334685431508 no 2409 0.290240930519427 3426 2838777 SGTC_1758 st042942 75.2445 µM -0.553900180069412 0.290933598988336 no 2410 0.289823580941249 3434 669317 SGTC_2325 6158266 200 µM -0.554839675944409 0.29062469753344 no 2411 0.289502163132726 3409 3623240 SGTC_2488 5268135 45.7 µM -0.554877757679766 0.290612179689333 no 2412 0.289489138242637 3433 1270356 YLR208W SEC13 SGTC_3334 9142812 21.919 µM -0.554898809239176 0.290605259941228 no 2413 0.28948193820969 3453 45283678 SGTC_2242 6630449 61.2675 µM -0.557144031064006 0.28986768774044 no 2414 0.288714513009606 3439 691249 YDR170C SEC7 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.557699900207514 0.28968521625354 no 2415 0.288524662922179 3463 165521 SGTC_398 bronopol 33.3 µM -0.557782639403128 0.289658060615155 no 2416 0.288496409425005 3367 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2224 6650123 117.647 µM -0.561464644422126 0.288450809855367 no 2417 0.287240413009109 3424 2908370 SGTC_1921 5740136 50 µM -0.561497459092655 0.288440061296324 no 2418 0.287229230994281 3474 1774243 SGTC_449 xestospongin c 11.1929 µM -0.562279060440407 0.288184100883772 no 2419 0.286962951345906 3447 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1810 st050138 53 µM -0.5642374089143 0.287543247933955 no 2420 0.286296285979892 3466 3444541 SGTC_1239 0337-0584 35.4 µM -0.565528425712744 0.287121142454485 no 2421 0.285857197708303 3524 914301 YML130C ERO1 SGTC_279 1273-0055 2.93 µM -0.565767684237233 0.287042947718055 no 2422 0.28577585857348 3451 2847562 SGTC_841 0251-0215 91.2 µM -0.567309979540907 0.286539135257088 no 2423 0.285251799025951 3443 3888614 SGTC_2097 5376186 200 µM -0.568103847706112 0.286279970693603 no 2424 0.284982227626635 3454 742755 SGTC_2877 9040724 71.43 µM -0.568795374268288 0.286054307099751 no 2425 0.284747507105188 3498 6463895 SGTC_3108 9121785 49.47 µM -0.569985818795587 0.285666031361217 no 2426 0.284343658256968 3452 17140271 SGTC_1667 st014849 34.6 µM -0.570382846999831 0.285536592308882 no 2427 0.284209030488815 3486 5348460 SGTC_3262 9137218 49.47 µM -0.57061672000006 0.285460358150668 no 2428 0.28412974106918 3370 17650664 SGTC_1365 1672-3266 55.4 µM -0.571466463346958 0.285183454085542 no 2429 0.283841743639356 3488 6415873 SGTC_2780 5215298 71.43 µM -0.572335582845983 0.284900368442871 no 2430 0.283547323826239 3495 2834131 SGTC_3050 9093513 49.47 µM -0.573754677956235 0.284438435576524 no 2431 0.283066911018286 3488 25236664 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.574316931131995 0.284255514294378 no 2432 0.282876676970479 3425 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2523 spermine 47.74 µM -0.574739654393155 0.284118024181647 no 2433 0.282733692243784 3445 1103 A DNA binding polyamine. SGTC_1895 st058434 18.3 µM -0.575438110192659 0.283890922186428 no 2434 0.282497518026987 3529 5393175 SGTC_3127 9126946 49.47 µM -0.575914285787183 0.283736144136105 no 2435 0.282336559521757 3402 27243249 SGTC_1477 0139-0234 16 µM -0.576307443088973 0.283608381153197 no 2436 0.282203696406554 3472 620880 SGTC_910 3454-3003 490 µM -0.579430642257681 0.28259442615613 no 2437 0.281149316601127 3489 820824 SGTC_1731 st035964 63 µM -0.579548322970073 0.282556254888372 no 2438 0.281109625279456 3383 6739575 SGTC_2352 9027995 87.8 µM -0.579714159228975 0.282502467951679 no 2439 0.281053696662098 3422 2997347 SGTC_1082 camptothecin 424.86 nM -0.579923493064077 0.282434580145215 no 2440 0.280983106075254 3359 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2721 ifenprodil 61.44 µM -0.581643221123187 0.281877162607077 no 2441 0.280403511886939 3513 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_25 0118-0223 35.662 µM -0.581742533031093 0.281844988714462 no 2442 0.280370058814058 3526 5333628 SGTC_2084 5306078 60.6385 µM -0.582151134363104 0.281712633528721 no 2443 0.280232442380832 3394 679340 SGTC_3189 9110682 49.47 µM -0.582315792594341 0.281659305486203 no 2444 0.280176994939837 3481 17122418 SGTC_3315 9136395 68.55 µM -0.585469080500144 0.280638986964371 no 2445 0.279116175471154 3565 16876844 SGTC_599 1935-0052 86.5 µM -0.588817342710717 0.279557541274877 no 2446 0.277991905339361 3445 9557311 SGTC_2247 cerulenin 830 nM -0.589234892386672 0.279422820113222 no 2447 0.277851856796111 3579 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_3291 9121177 71.43 µM -0.589453648914675 0.279352251560114 no 2448 0.277778498360866 3438 17015612 SGTC_2315 7733312 200 µM -0.589586807215365 0.279309300333765 no 2449 0.277733849309197 3437 726316 SGTC_3138 9097216 49.47 µM -0.590259363076918 0.279092411352244 no 2450 0.277508389479368 3524 25237486 SGTC_2401 5128683 200 µM -0.591035550380532 0.278842204649776 no 2451 0.277248300681472 3424 708373 SGTC_1163 k060-0048 49.9 µM -0.59180528178005 0.278594186877708 no 2452 0.276990492965878 3510 6809982 SGTC_2971 9092186 9.93 µM -0.592032612684654 0.27852095836979 no 2453 0.276914375014355 3383 25236400 SGTC_2114 5491910 81.25 µM -0.592662953533301 0.278317960156289 no 2454 0.276703369511999 3540 2849228 SGTC_473 2-arachidonoylglycerol 10 µM -0.594297643312318 0.277791852523258 no 2455 0.276156527305483 3406 5282280 An endocannabinoid. SGTC_1527 coumarin 137 µM -0.594667407934949 0.277672915065249 no 2456 0.276032905941898 3536 323 A hepatotoxic, DNA x-linker. SGTC_2318 6029776 164 µM -0.596609868671301 0.277048517433274 no 2457 0.275383940452187 3548 818325 SGTC_219 mitoxanthrone 164.414 µM -0.596797835098589 0.276988132728772 no 2458 0.275321181759892 3470 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1818 st052136 56.3 µM -0.597056845975131 0.2769049353673 no 2459 0.27523471410646 3475 674169 SGTC_1344 1488-0097 29.1 µM -0.597334440150572 0.27681578241735 no 2460 0.275142057487259 3514 747966 SGTC_2976 9009005 19.48 µM -0.597679560012652 0.27670496233133 no 2461 0.275026883267196 3552 2993148 SGTC_2948 9070189 9.45 µM -0.599823810474578 0.276016917983637 no 2462 0.274311831537784 3476 6473636 YDL196W YDL196W SGTC_2374 9071832 200 µM -0.601030291025085 0.275630153738627 no 2463 0.273909905586559 3499 17381698 SGTC_963 1269-2853 151 µM -0.601415106797691 0.275506848533511 no 2464 0.273781769637404 3477 3668223 SGTC_223 busulfan 5 mM -0.605366442520795 0.274242307401297 no 2465 0.27246777147823 3505 2478 A DNA alkylator. SGTC_1908 st060353 56.5 µM -0.605645550315092 0.274153093373431 no 2466 0.272375074045705 3587 4227716 SGTC_1377 2944-0135 198 µM -0.608522144372033 0.273234454882081 no 2467 0.271420611784715 3551 1894137 SGTC_2011 4012611 177 µM -0.608925517580882 0.273105759919039 no 2468 0.271286904720198 3510 2049887 SGTC_2393 9031399 185.94 µM -0.609245759742029 0.273003609054321 no 2469 0.271180776682322 3579 1526623 YDL150W RPC53 SGTC_892 0929-0076 29 µM -0.609452404212239 0.272937703644667 no 2470 0.271112305833146 3510 5751038 SGTC_2532 xanthone 78.9 µM -0.610138776402513 0.27271885463992 no 2471 0.270884940946864 3460 7020 An insecticide. SGTC_1094 duloxetine 25.4 µM -0.61255799162285 0.271948185569898 no 2472 0.270084320994348 3530 60834 A selective serotonin reuptake inhibitor. SGTC_2462 5162487 171.77 µM -0.612717283911787 0.271897479200091 no 2473 0.270031646053414 3522 2259986 SGTC_1759 st043059 70 µM -0.612780057513854 0.271877498222429 no 2474 0.270010889425031 3464 669426 SGTC_680 0417-1641 114 µM -0.616028567606176 0.27084448837025 no 2475 0.268937832707026 3491 2835990 SGTC_1144 3486-0183 12.5 µM -0.61738697570454 0.270413103043762 no 2476 0.268489755319024 3505 6744069 SGTC_2819 7996655 46.38 µM -0.61955761393799 0.269724493896714 no 2477 0.267774539833297 3427 6456960 SGTC_2972 9093619 59.92 µM -0.61967670303606 0.26968673972664 no 2478 0.267735328308986 3496 25236256 SGTC_2116 5511452 16.8835 µM -0.620664868984984 0.269373568986197 no 2479 0.267410074383002 3535 870744 SGTC_3008 9078912 71.4286 µM -0.621141951175258 0.269222436817558 no 2480 0.267253114583043 3542 16648731 SGTC_1779 st039427 55 µM -0.621220850643339 0.269197446800641 no 2481 0.267227161178783 3596 1124498 SGTC_864 0469-0573 172 µM -0.621452477828813 0.269124089692316 no 2482 0.26715097645554 3488 689425 SGTC_1734 st037168 69.4 µM -0.621651379876094 0.269061104750996 no 2483 0.267085564140475 3494 708907 SGTC_3144 9087057 49.47 µM -0.622263581270713 0.268867289590258 no 2484 0.266884282080476 3516 17249618 SGTC_3194 9111903 49.47 µM -0.624128040414114 0.268277457795966 no 2485 0.266271750099214 3580 17087251 SGTC_1916 st067606 49.2 µM -0.627479217080527 0.267218933879008 no 2486 0.265172577604562 3538 19590279 SGTC_2372 9071633 200 µM -0.627606756771381 0.267178690059899 no 2487 0.26513079065902 3596 21321366 SGTC_2066 5222451 176 µM -0.628060501902664 0.267035540323376 no 2488 0.264982153288582 3570 2281147 SGTC_667 1498-1044 59 µM -0.630719462732206 0.266197457560257 no 2489 0.264111985482291 3558 6739982 SGTC_3302 9125395 16.351 µM -0.630846491814915 0.266157452382743 no 2490 0.26407045058626 3513 17599668 SGTC_2452 5863136 48.41 µM -0.632395365530416 0.265669911666108 no 2491 0.263564280769833 3549 2184096 SGTC_27 0485-0001 32.618 µM -0.63305308961156 0.265463016183908 no 2492 0.263349487292546 3521 2054479 SGTC_1675 st018485 24.5 µM -0.634283516734989 0.265076189310919 no 2493 0.262947905868386 3526 3323024 SGTC_2489 cantharidin 73.42 µM -0.636622694846993 0.264341579067534 no 2494 0.262185319388338 3578 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_254 nsc-64875 3.808 µM -0.63694193807489 0.264241402347911 no 2495 0.262081332076812 3590 56993 SGTC_3296 9122258 64.045 µM -0.637870237024786 0.263950217269304 no 2496 0.261779076781057 3565 4730474 SGTC_2098 5376439 882.5 nM -0.638138498401359 0.263866100590784 no 2497 0.261691763859133 3612 2844116 SGTC_3044 9093193 49.47 µM -0.638606466344103 0.263719396165654 no 2498 0.261539486811522 3550 25236277 SGTC_797 k781-0471 270 µM -0.639331474259926 0.263492193826536 no 2499 0.261303658663245 3551 23738129 SGTC_1999 st074831 12.5 µM -0.639387106903579 0.263474763845945 no 2500 0.261285567176889 3533 17112523 SGTC_1413 3910-0535 34.4 µM -0.641245874331237 0.262892741386399 no 2501 0.260681474483811 3586 2876951 SGTC_654 1124-0271 80.9 µM -0.641667276737881 0.262760882156011 no 2502 0.26054462024547 3571 5403748 SGTC_1429 4049-0205 9.46 µM -0.642383010985529 0.262537002352757 no 2503 0.260312263880944 3616 22774478 SGTC_1271 0832-2808 169 µM -0.64379931101566 0.262094275335708 no 2504 0.259852790304741 3612 3663794 SGTC_287 k060-0039 29.6 µM -0.644228639003199 0.261960145559844 no 2505 0.259713591156513 3610 5861974 SGTC_2202 7226349 200 µM -0.645111923995058 0.261684302191066 no 2506 0.259427328587108 3544 844334 SGTC_749 1000-0129 128 µM -0.645149779625962 0.261672483489228 no 2507 0.259415063653108 3640 708470 SGTC_1228 0124-0032 52.5 µM -0.645249749385061 0.261641273788116 no 2508 0.259382675658098 3601 X1228 SGTC_1414 3917-0015 5.4 µM -0.646067273167812 0.26138612158399 no 2509 0.259117894414727 3575 6618702 SGTC_451 chloral hydrate 100 µM -0.650654274885549 0.259956875174146 no 2510 0.257634843044303 3638 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1133 3473-0247 50 µM -0.652303126471537 0.259444102381313 no 2511 0.257102821774726 3552 711311 SGTC_1740 st038286 13.222 µM -0.652870223037886 0.259267863065559 no 2512 0.25691997356103 3614 716786 SGTC_924 2046-0044 21.3 µM -0.652999597700259 0.259227665351193 no 2513 0.256878268936521 3618 3623589 SGTC_1042 0350-0096 82 µM -0.653688008835748 0.259013824839383 no 2514 0.256656415130624 3596 3122515 SGTC_1168 k815-0004 80.5 µM -0.655035525297711 0.258595511268174 no 2515 0.256222440845355 3581 642433 SGTC_176 1486-1328 72.834 µM -0.655550380579176 0.258435775614071 no 2516 0.2560567302463 3602 22310231 SGTC_1679 SEC14.276 6.7 µM -0.656003989462911 0.258295084237025 no 2517 0.25591077866367 3621 1005053 YMR079W SEC14 SGTC_8 0354-0001 70 µM -0.657293717801259 0.25789527895057 no 2518 0.255496037570511 3641 4993152 SGTC_3256 9138902 49.47 µM -0.657453364463392 0.257845812127034 no 2519 0.255444724038903 3612 17228773 SGTC_3175 9106517 49.47 µM -0.65853617847041 0.257510430133713 no 2520 0.255096828808274 3590 41468073 SGTC_805 3852-0218 479 µM -0.658934399721131 0.257387145341247 no 2521 0.254968947426463 3577 6615355 SGTC_3206 9114350 49.47 µM -0.659664749528653 0.257161117038118 no 2522 0.254734496312377 3569 17087243 SGTC_1519 esterone 74 µM -0.660923487726347 0.256771805708769 no 2523 0.254330691212386 3580 698 A steroid. SGTC_2827 7993847 71.43 µM -0.662149749215349 0.256392834235996 no 2524 0.253937627599814 3566 2985692 SGTC_1427 4048-4900 550 nM -0.662396005861495 0.256316764710446 no 2525 0.253858731400771 3610 24132586 SGTC_2592 piperlongumine 83.33 µM -0.662886850352932 0.256165176256922 no 2526 0.253701512046747 3572 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_756 0508-1999 28.3 µM -0.663840098653775 0.255870916348716 no 2527 0.253396329133568 3587 6753853 SGTC_2126 5251174 33.877 µM -0.665994419717665 0.255206545583578 no 2528 0.252707333606227 3650 790722 SGTC_1891 st059073 26.2 µM -0.666095364987167 0.255175437224143 no 2529 0.252675073477884 3664 688754 SGTC_1493 4348-0038 111 µM -0.667936686422559 0.254608344341027 no 2530 0.2520870040807 3656 800424 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.668190535145569 0.254530215446033 no 2531 0.252005988176612 3597 689007 SGTC_514 4466-0038 2.65 nM -0.669012331316348 0.254277371348448 no 2532 0.251743805916849 3585 5722064 SGTC_852 0418-0143 439 µM -0.669770110547429 0.254044340251787 no 2533 0.251502175044304 3653 5369229 SGTC_2519 cryptotanshinone 88.04 µM -0.671302538027987 0.253573433124354 no 2534 0.251013909074472 3614 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1396 3511-0007 98.6 µM -0.671398663646676 0.253543909505022 no 2535 0.250983298010355 3581 X1396 SGTC_660 4031-1742 102 µM -0.672954537207521 0.253066296313353 no 2536 0.250488107200492 3561 6738706 SGTC_2962 9082311 13.18 µM -0.673186181389105 0.252995228005942 no 2537 0.250414425674297 3617 16459453 SGTC_3186 9110464 49.47 µM -0.673315688132064 0.252955499985813 no 2538 0.250373237095478 3644 17018021 SGTC_943 3253-1379 105 µM -0.67554376855389 0.252272519323781 no 2539 0.249665176751857 3636 668464 SGTC_3142 9086498 49.47 µM -0.677308721282083 0.251732193631578 no 2540 0.249105049300189 3587 25236367 SGTC_1349 flufenamic acid 69 µM -0.678296206833205 0.251430149918389 no 2541 0.24879195161986 3610 3371 A non-steroidal anti-inflammatory. SGTC_2108 5365811 200 µM -0.67892361182554 0.251238344149973 no 2542 0.248593131994924 3663 780283 SGTC_2576 guaiol 23.12 µM -0.68131857311019 0.250506885697081 no 2543 0.247834966772987 3646 227829 SGTC_2557 derrustone 83.84 µM -0.681381880204294 0.25048756604519 no 2544 0.24781494260797 3646 629853 An antioxidant. SGTC_2409 alverine citrate 63.97 µM -0.68242337421426 0.250169842974448 no 2545 0.247485639918873 3731 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1781 st038725 66.3 µM -0.682565516628696 0.250126496922349 no 2546 0.247440715045865 3663 4270275 YIL048W NEO1 SGTC_1792 st045773 43.6 µM -0.683397399546821 0.249872895753371 no 2547 0.247177881395781 3601 2919270 SGTC_2371 9071574 200 µM -0.685990471608049 0.249083269171506 no 2548 0.246359558496512 3627 45596039 SGTC_107 0358-0022 2.6945 µM -0.686726544943621 0.248859366717058 no 2549 0.246127533012991 3646 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2934 9036370 36.88 µM -0.687349651840005 0.248669910725557 no 2550 0.245931208519111 3666 6462800 SGTC_1282 0886-0010 32.4 µM -0.688837337631771 0.248217889872629 no 2551 0.24546281812617 3716 2836211 YNL267W PIK1 SGTC_2439 5492030 7.2 µM -0.690227218591966 0.24779598242492 no 2552 0.245025654556833 3639 5722370 SGTC_2960 9079389 5.97 µM -0.69136220334214 0.247451734577535 no 2553 0.244668975182816 3637 16457355 SGTC_2020 4017018 200 µM -0.691401698256104 0.247439760130561 no 2554 0.244656568579343 3694 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_636 0kpi-0074 126 µM -0.691603003074841 0.247378731416012 no 2555 0.24459333762369 3657 616434 SGTC_1154 4088-0362 150 µM -0.693876774170714 0.246689961037513 no 2556 0.243879745113138 3689 6618304 SGTC_2787 5284540 71.43 µM -0.694340000294371 0.246549766682012 no 2557 0.243734505692369 3675 736958 SGTC_532 1548-0774 215 µM -0.694377259598187 0.246538492091546 no 2558 0.2437228254796 3761 5932993 SGTC_2800 7887935 81.82 µM -0.694850883251958 0.246395198600187 no 2559 0.243574378161536 3643 2961002 SGTC_3187 9109394 49.47 µM -0.695073831972381 0.246327761552453 no 2560 0.243504516507312 3621 17098090 SGTC_1499 4480-0877 67.3 µM -0.695407778427698 0.246226768661021 no 2561 0.243399893629746 3615 2861909 SGTC_1260 0700-1617 7.75 µM -0.698419711217305 0.24531689668223 no 2562 0.24245737643493 3680 2853078 SGTC_3088 9117578 49.47 µM -0.700298078855263 0.244750378663004 no 2563 0.241870585639193 3727 678341 SGTC_554 4483-2211 187 µM -0.702298324643276 0.244147877245124 no 2564 0.241246568930859 3689 747107 SGTC_2896 9052656 71.43 µM -0.702928183818459 0.243958320746062 no 2565 0.241050253044133 3649 6469436 SGTC_2335 9018011 154.17 µM -0.703619675392865 0.243750307409223 no 2566 0.240834827507276 3715 6458208 SGTC_2249 haloperidol 116.36 µM -0.705589125714679 0.243158385706314 no 2567 0.240221844347884 3681 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2210 7115885 190.385 µM -0.70989616094146 0.241866611667169 no 2568 0.238884265644876 3713 2927039 SGTC_2994 9053520 71.4286 µM -0.710624087267162 0.241648659054235 no 2569 0.238658606291546 3687 4647384 SGTC_1941 st076221 61.8 µM -0.711224226063462 0.241469048262272 no 2570 0.238472649222268 3674 2828568 SGTC_3179 9107801 49.47 µM -0.711886516553502 0.241270920773969 no 2571 0.238267526139862 3699 4818259 SGTC_2688 kanamycin b 96.69 µM -0.712137553304636 0.241195844979274 no 2572 0.23818980088431 3803 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1534 6-azauridine 81.6 µM -0.71223569124644 0.241166499008214 no 2573 0.238159419482686 3733 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2814 7977482 42.97 µM -0.714237598728757 0.240568296870807 no 2574 0.237540135542713 3755 6456762 SGTC_366 0181-0206 4.31 µM -0.715619689387082 0.240155777830312 no 2575 0.237113106278054 3700 274874 SGTC_564 3555-0129 330 µM -0.71571494683261 0.240127360106071 no 2576 0.23708368980602 3610 563260 SGTC_3270 9137563 49.47 µM -0.717966047405361 0.239456333191697 no 2577 0.236389110925889 3695 17015724 SGTC_2416 tofa 880 nM -0.718146444466119 0.239402603277129 no 2578 0.236333497791991 3711 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2831 7999036 19.48 µM -0.719453464188317 0.239013513974363 no 2579 0.23593078261775 3716 2988270 SGTC_3136 9095672 49.47 µM -0.72184142993713 0.23830352940783 no 2580 0.235195987203523 3523 17217380 SGTC_740 k014-0057 261 µM -0.722739592976399 0.238036788862027 no 2581 0.234919942928589 3730 4012779 SGTC_2895 9054447 58.44 µM -0.72290753407276 0.237986931118419 no 2582 0.23486834725544 3745 2697450 SGTC_1259 0671-0132 43 µM -0.723286605083824 0.237874414938405 no 2583 0.234751910258289 3665 X1259 SGTC_2778 tioconazole 65.09 nM -0.723813657282992 0.237718023342145 no 2584 0.234590071801338 3676 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2215 7188065 200 µM -0.723919802644496 0.237686533775569 no 2585 0.23455748590931 3709 940217 SGTC_1949 st076024 69.1 µM -0.724516462051446 0.237509568671485 no 2586 0.234374362196431 3693 2921930 SGTC_1643 st009866 20.2 µM -0.725414875442061 0.237243241880675 no 2587 0.234098774981344 3702 3156273 YOR207C RET1 SGTC_2245 6637752 200 µM -0.725557759290832 0.23720090033717 no 2588 0.234054962080147 3729 681890 SGTC_1412 3909-8563 178 µM -0.725773007687561 0.237137122453779 no 2589 0.233988968396419 3791 23767530 SGTC_607 4491-0986 66.8 µM -0.72580739439604 0.237126934579523 no 2590 0.233978426622135 3715 698981 YDR232W HEM1 SGTC_179 1273-0063 6.77 µM -0.726262108695186 0.236992237350781 no 2591 0.233839051706032 3710 3108139 SGTC_2327 6189656 200 µM -0.727835179203281 0.236526580872082 no 2592 0.233357243424449 3774 5349088 SGTC_1389 3405-0187 19 µM -0.728395147048756 0.236360942158413 no 2593 0.233185866566618 3688 799890 SGTC_2837 9008476 45.46 µM -0.728934963269221 0.236201324776739 no 2594 0.233020723225808 3721 2992805 SGTC_1421 4029-0249 71.4 µM -0.729388342654095 0.23606731164561 no 2595 0.232882073281014 3795 2894095 SGTC_2626 ethyl orsellinate 100 µM -0.729842086207237 0.235933232824382 no 2596 0.23274335786609 3720 75653 A natural product. SGTC_1959 st077091 55.8 µM -0.731739026213547 0.235373151858262 no 2597 0.232163935711178 3735 821356 YKL052C ASK1 SGTC_128 0906-2981 13.371 µM -0.732577355961493 0.235125864857861 no 2598 0.231908123106903 3687 6740226 SGTC_603 3794-0023 45.9 µM -0.733895828470633 0.234737237826002 no 2599 0.231506114845687 3722 3802260 SGTC_1313 1220-0047 237 µM -0.734114790632141 0.234672731926925 no 2600 0.231439389925107 3733 3528706 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.734411498020061 0.234585338052263 no 2601 0.231348990608307 3667 17037758 SGTC_1521 st012942 49.4 µM -0.734761703063329 0.234482209841338 no 2602 0.231242317238355 3779 24207259 SGTC_1497 4476-2978 41.3 µM -0.736246585448663 0.234045221157574 no 2603 0.230790323151386 3746 1528379 SGTC_1494 4358-1428 177 µM -0.738132190894992 0.233490953641724 no 2604 0.230217061903881 3748 1564571 SGTC_3004 9076122 71.4286 µM -0.738470538266648 0.23339157464304 no 2605 0.230114281973245 3725 44782551 SGTC_1888 azatryptophan 97.5 µM -0.740056825923765 0.232925965126098 no 2606 0.229632757150974 3741 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2712 st079126 47.7 µM -0.740114532065762 0.232909036865161 no 2607 0.229615250835929 3737 3152970 SGTC_2294 7971431 200 µM -0.741648751603047 0.232459219906172 no 2608 0.229150088848538 3693 5741572 SGTC_2932 9016711 44.54 µM -0.743575858832557 0.231894897626635 no 2609 0.228566556323093 3733 7117328 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.74404827072522 0.231756675957294 no 2610 0.228423636395321 3740 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2406 ethylparaben 405.7 µM -0.746143714260946 0.231144129693792 no 2611 0.22779030242142 3775 8434 A possible steroid mimic. SGTC_3306 9127676 59.7925 µM -0.747261860312805 0.230817639942772 no 2612 0.227452754935518 3757 41905287 SGTC_2027 5150920 200 µM -0.74755439729669 0.230732263996127 no 2613 0.227364489983534 3722 786715 SGTC_1819 st053448 58.6 µM -0.748220217523144 0.230538012356457 no 2614 0.227163669086718 3695 2857616 SGTC_134 0269-0018 6.916 µM -0.748469578064549 0.230465285478838 no 2615 0.227088484125341 3690 4378915 SGTC_1351 1496-0003 46.5 µM -0.749024902893739 0.230303369133504 no 2616 0.226921097967344 3779 3891978 SGTC_387 norethindrone acetate 66.7 µM -0.749711768158909 0.230103187506355 no 2617 0.226714159154499 3763 541197 SGTC_1604 st002052 72.4 µM -0.75111902394931 0.229693357782838 no 2618 0.226290513817244 3765 6254834 YHR062C RPP1 SGTC_1736 st036774 51 µM -0.751482021487842 0.229587709764071 no 2619 0.226181308333442 3832 1272247 SGTC_2655 perillic acid 100 µM -0.752289693422702 0.229352739921278 no 2620 0.225938432281591 3772 5702197 An apoptosis inducer. SGTC_1702 st027038 51 µM -0.753624065267768 0.228964836778546 no 2621 0.22553749486946 3767 5521182 SGTC_3345 9148410 3.559 µM -0.753808405614049 0.22891127782319 no 2622 0.225482137978936 3709 4903596 SGTC_2848 9016370 25.97 µM -0.75431024394764 0.228765507407115 no 2623 0.225331476305032 3747 7894410 SGTC_2605 digitonin 300 nM -0.756405010630701 0.228157597631833 no 2624 0.224703202370141 3787 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1131 3454-3128 32.3 µM -0.756934685522901 0.228004027827651 no 2625 0.224544496877097 3849 710982 SGTC_704 1310-0270 142 µM -0.758215004325617 0.227633062412413 no 2626 0.224161140131848 3747 5718033 SGTC_2258 7960471 200 µM -0.758255654881057 0.227621289703363 no 2627 0.224148974516491 3760 2974708 SGTC_414 piperonyl butoxide 100 µM -0.758268450187262 0.227617584156611 no 2628 0.22414514530388 3757 5794 A potent inhibitor of cytochrome P450. SGTC_777 1315-0167 517 µM -0.75846911945204 0.227559474371991 no 2629 0.224085096479971 3812 4221767 SGTC_631 k072-0230 41.5 µM -0.759253229386946 0.227332492012881 no 2630 0.223850544893528 3786 5773147 SGTC_24 0417-1663 219 µM -0.760813833538484 0.22688111169827 no 2631 0.223384135282639 3728 4329390 SGTC_725 1497-0963 19 µM -0.762181516057794 0.226485946951489 no 2632 0.222975838191323 3799 3549977 SGTC_1597 7-benzyloxygramine 47.5 µM -0.762501899698371 0.226393434662274 no 2633 0.22288025488548 3753 260807 SGTC_879 0831-1030 162 µM -0.762594796206169 0.226366614348603 no 2634 0.222852544492815 3804 1549252 SGTC_991 3996-0057 64.7 µM -0.763095930724438 0.226221961879137 no 2635 0.222703093354899 3815 715343 SGTC_2683 piperine 63.03 µM -0.763552429145645 0.226090239086262 no 2636 0.222567003576546 3749 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1293 1000-1278 195 µM -0.763724864328314 0.226040494130867 no 2637 0.222515610118546 3824 678847 SGTC_1079 idarubicin 2.36 µM -0.764342485446645 0.225862370505868 no 2638 0.222331586718385 3739 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1255 0566-0045 221 µM -0.76453659830591 0.225806404223245 no 2639 0.22227376772666 3837 2788469 SGTC_2984 9022109 38.96 µM -0.765348253703439 0.225572474131896 no 2640 0.222032098765485 3814 6459207 SGTC_648 0375-0473 33.3 µM -0.766200531809511 0.225326983708838 no 2641 0.221778495998552 3778 1713139 SGTC_988 1497-1057 103 µM -0.767201714585088 0.225038796084307 no 2642 0.221480796822872 3754 3533044 SGTC_3170 9103054 49.47 µM -0.769384410328342 0.224411237896498 no 2643 0.220832570277782 3793 16432970 SGTC_618 k072-0232 33.2 µM -0.769924874718866 0.224255999733393 no 2644 0.220672228751454 3808 5872756 YGL099W LSG1 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.77064734346982 0.224048579523225 no 2645 0.220457995521576 3796 5106787 A p450 inhibitor. SGTC_2359 9039622 200 µM -0.771387161692894 0.223836291278587 no 2646 0.220238741238281 3747 6463596 SGTC_3085 9117376 49.47 µM -0.771552620812926 0.223788829012499 no 2647 0.220189722495769 3886 16480349 SGTC_2096 5468907 200 µM -0.771750759248068 0.223732000149926 no 2648 0.220131030447454 3826 759785 SGTC_700 3453-2283 142 µM -0.772090274357624 0.223634641564465 no 2649 0.220030481034882 3837 565664 SGTC_1214 0358-0031 63.7 µM -0.77436451692361 0.222983106418336 no 2650 0.219357630366618 3913 4301366 SGTC_2184 6075246 200 µM -0.775220794606923 0.2227380766145 no 2651 0.219104601306362 3842 2267320 SGTC_3330 9141424 71.43 µM -0.77563217923866 0.222620410638925 no 2652 0.218983097332834 3863 27261020 SGTC_2463 5473429 200 µM -0.776120600880876 0.222480756232762 no 2653 0.218838890525655 3797 5399405 SGTC_2444 5485484 36.41 µM -0.77743403663734 0.222105453452486 no 2654 0.218451368908069 3879 6790631 SGTC_1218 1348-1416 30.7 µM -0.777538197416868 0.222075705894127 no 2655 0.218420653795551 3754 6787668 SGTC_778 3456-2434 196 µM -0.777916146688351 0.221967785441333 no 2656 0.21830922434373 3834 5539063 SGTC_3213 9129884 49.47 µM -0.779354188940105 0.221557437583326 no 2657 0.217885550894858 3796 17190742 SGTC_2699 st077704 54.6 µM -0.780104771786298 0.221343429796375 no 2658 0.217664603982011 3823 645852 SGTC_441 propafenone 146 µM -0.780190120330405 0.221319102524378 no 2659 0.217639488365132 3764 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_587 k089-0003 57 µM -0.780419472663333 0.221253736793442 no 2660 0.21757200486867 3712 9659696 SGTC_3325 9138760 55.175 µM -0.782965930555206 0.220528735098599 no 2661 0.216823559485867 3779 43844959 SGTC_56 0957-0365 83.25 µM -0.783402356240805 0.220404617185346 no 2662 0.216695436468874 3784 6752360 SGTC_1054 3429-0080 167 µM -0.784403662443733 0.220120000629668 no 2663 0.216401645032287 3797 1162877 SGTC_814 3342-0569 96 µM -0.785652784219255 0.219765239371678 no 2664 0.216035465847351 3846 4346283 SGTC_3312 9133330 71.43 µM -0.78736295823029 0.219280068062132 no 2665 0.215534712074096 3866 17617324 SGTC_95 0471-0001 561.058 µM -0.789988225967908 0.218536486539786 no 2666 0.214767322241498 3766 4015405 SGTC_3198 9112019 49.47 µM -0.791490163285921 0.218111731149506 no 2667 0.214329007038231 3863 45595555 SGTC_311 1315-0136 58 µM -0.792245500621302 0.217898297924454 no 2668 0.214108771285134 3872 6759207 SGTC_1833 st055984 71 µM -0.794600349282118 0.217233669547731 no 2669 0.213423007553594 3860 676288 SGTC_2504 purpurogallin 52.29 µM -0.798331059418206 0.21618312105446 no 2670 0.212339199249441 3755 5281571 An antioxidant. SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.798444154749744 0.216151320010932 no 2671 0.212306394241463 3875 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2714 st079313 56.9 µM -0.801362864265648 0.215331551671049 no 2672 0.211460803591119 3815 2939799 SGTC_1603 st002045 67.8 µM -0.802558543642058 0.214996246718693 no 2673 0.21111496893829 3834 5887985 SGTC_1011 4112-3381 17.4 µM -0.803116975898839 0.214839749217827 no 2674 0.21095356332336 3928 2877139 SGTC_1496 4469-0713 57.4 µM -0.80428632274388 0.21451226079396 no 2675 0.210615817403682 3793 746691 SGTC_189 3970-0742 2.116 µM -0.804740345168323 0.214385185089697 no 2676 0.210484766319684 3808 2891807 SGTC_2809 7964133 12.99 µM -0.804976016659182 0.214319240588052 no 2677 0.210416759909529 3864 1253665 SGTC_2131 toluylene red 5.2905 µM -0.805138900533837 0.214273670074982 no 2678 0.210369764955631 3848 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_3161 9100388 49.47 µM -0.806973487673144 0.213760791493994 no 2679 0.209840878977353 3861 25236368 SGTC_1882 5615643 20 µM -0.808674340095015 0.213285939223754 no 2680 0.209351245788789 3762 2253075 SGTC_3093 9117344 49.47 µM -0.810433286401851 0.212795515551093 no 2681 0.208845596687229 3898 24824913 SGTC_2295 7971645 200 µM -0.810995162279491 0.212638993985875 no 2682 0.208684224462282 3900 2978226 YKL099C UTP11 SGTC_2856 9022925 19.48 µM -0.811086346557573 0.212613599155893 no 2683 0.208658043031602 3886 4944862 SGTC_2844 9010103 25.97 µM -0.811650265973604 0.212456586898306 no 2684 0.208496169791576 3910 2480525 SGTC_1839 st053978 48 µM -0.814405271694502 0.211690484300896 no 2685 0.207706409807812 3863 3788398 SGTC_261 5-fluorouridine 15.376 µM -0.814762947706837 0.211591141692898 no 2686 0.207604006868923 3858 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_770 0389-1121 67.2 µM -0.814765884759193 0.211590326055234 no 2687 0.207603166111905 3989 6753108 SGTC_1935 st074532 41.6 µM -0.817303065499612 0.210886423035055 no 2688 0.206877627680127 3876 2829742 SGTC_1834 st055981 52.8 µM -0.820061311006215 0.210122748891779 no 2689 0.20609057815917 3919 471719 YDL150W RPC53 SGTC_3054 9094397 49.47 µM -0.82051193274937 0.209998140023889 no 2690 0.205962164768615 3884 2598354 SGTC_2790 5423970 71.43 µM -0.82423335402355 0.208970729488176 no 2691 0.204903489313642 3930 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2695 st077686 51.995 µM -0.82657597700837 0.208325499077839 no 2692 0.204238719073606 3923 2876092 SGTC_565 1418-0001 44.5 µM -0.828774229255001 0.207721102969752 no 2693 0.203616086699141 3940 2862145 SGTC_429 1112-0049 25.5 µM -0.832225628202189 0.206774254500777 no 2694 0.202640800303717 3852 2836170 SGTC_1843 st055809 45.5 µM -0.833856308770738 0.206327787786288 no 2695 0.202180980105939 3938 16413835 SGTC_881 0833-0569 170 µM -0.834112528360032 0.20625768897559 no 2696 0.202108787956371 3888 5418700 SGTC_1773 st048542 73.5835 µM -0.83522056569006 0.205954704933481 no 2697 0.20179676620946 3825 3237138 SGTC_3356 9151811 4.48 µM -0.83543744319175 0.205895432403988 no 2698 0.201735727583321 3868 1859254 YPR165W RHO1 SGTC_683 panaxydol 45 µM -0.835496174891538 0.205879382796703 no 2699 0.201719199868072 3862 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1486 3970-0793 4.53 µM -0.836160151743707 0.20569798952174 no 2700 0.201532406244597 3921 2844330 SGTC_84 0443-0269 128.823 µM -0.837148452774676 0.205428169156433 no 2701 0.201254563973535 3778 6150058 SGTC_2428 5615643 7.78 µM -0.837591650551295 0.205307238097758 no 2702 0.201130041864667 3930 2253075 SGTC_528 3492-0019 172 µM -0.837804817578428 0.205249088352747 no 2703 0.201070166309732 3881 2869262 SGTC_3157 9099274 49.47 µM -0.83795429390125 0.205208318605532 no 2704 0.201028186935999 3850 17217662 SGTC_2276 7947513 42.08 µM -0.84067099808437 0.204468174860581 no 2705 0.200266136117616 3828 2105100 SGTC_2469 5655019 90.81 µM -0.840894210068868 0.20440743330485 no 2706 0.200203601161667 3960 2788239 SGTC_2880 9042983 58.44 µM -0.840951887569595 0.204391739562907 no 2707 0.200187444170562 3921 6464714 SGTC_417 st075190 100 µM -0.842437153661023 0.203987853641944 no 2708 0.199771651882379 3881 222757 SGTC_1569 carminic acid 40.6 µM -0.845669373864439 0.203110566495044 no 2709 0.198868606386533 3963 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_664 1222-0054 14.9 µM -0.850440355209148 0.201819753997872 no 2710 0.197540153940658 3860 6813991 SGTC_1281 0884-0031 11.8 µM -0.85244711238971 0.201278286789204 no 2711 0.196982990537447 3907 1548255 SGTC_2773 thioridazine 9.09 µM -0.853403456085152 0.201020550946373 no 2712 0.196717802791962 3912 5452 An antipsychotic. SGTC_2866 9034245 58.44 µM -0.854162674919344 0.200816081540346 no 2713 0.196507430505521 3881 6462273 SGTC_1068 loratadine 26.9 µM -0.856557161577801 0.20017202722135 no 2714 0.195844834636178 3966 3957 A H1 histamine antagonist. SGTC_2158 5657123 3.6195 µM -0.856814382619769 0.200102915403893 no 2715 0.19577373785879 3850 2858827 SGTC_895 0964-0006 13.7 µM -0.856968807763452 0.200061430346267 no 2716 0.19573106174637 3883 6738897 SGTC_1783 st039459 87.517 µM -0.857540516013244 0.19990789058833 no 2717 0.195573116648001 4023 729761 SGTC_1938 st074717 56.4 µM -0.857640303001674 0.199881098747701 no 2718 0.19554555656081 3745 17250979 SGTC_1073 triclabendazole 3.09 µM -0.858030344826134 0.199776397011047 no 2719 0.19543785385373 3988 50248 An antihelmetic and likely tubulin inhibitor. SGTC_224 benfluorex 43.875 µM -0.858352857900714 0.199689847426324 no 2720 0.195348825159035 3896 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1187 1391-0724 117 µM -0.858782143931872 0.199574679264744 no 2721 0.195230360364486 3968 6997986 SGTC_2030 5175110 200 µM -0.859371562708568 0.199416616086441 no 2722 0.195067776839416 3973 2831986 SGTC_1263 0774-1208 64.8 µM -0.860263927054274 0.19917745611402 no 2723 0.194821786395469 3920 906585 SGTC_3140 9094243 49.47 µM -0.860717451607008 0.199055974562173 no 2724 0.194696839506348 3915 19291112 SGTC_1128 3448-9350 235 µM -0.861838825227783 0.198755793989388 no 2725 0.194388108274873 3975 619386 SGTC_91 0417-1751 58.384 µM -0.86220784950847 0.19865706957484 no 2726 0.194286575485792 4020 6795624 SGTC_1283 0922-0125 16.4 µM -0.862452397148333 0.19859166247136 no 2727 0.194219308808221 3928 3360884 SGTC_2977 9011197 71.43 µM -0.863101933571045 0.19841799949567 no 2728 0.194040712471637 4021 2704722 SGTC_2357 9067248 200 µM -0.863603744197702 0.198283895914229 no 2729 0.193902803310925 3928 9150235 SGTC_512 prima-1 270 µM -0.86413392875215 0.198142269148012 no 2730 0.193757161254608 3941 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.864342091168499 0.198086679985854 no 2731 0.1936999971351 3913 688669 SGTC_1616 st002734 56.1 µM -0.865896932440254 0.197671762128771 no 2732 0.193273342742724 3871 4026101 SGTC_424 splitomicin 100 mM -0.866680150473254 0.197462955220487 no 2733 0.193058642108773 4022 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1637 st007924 17.4 µM -0.86706757616245 0.197359716368779 no 2734 0.19295249240703 3879 683336 SGTC_71 0417-1750 47.813 µM -0.868166252984527 0.197067125224687 no 2735 0.192651662881227 3897 6811472 SGTC_810 3825-7150 143 µM -0.868325430570152 0.197024756059777 no 2736 0.192608102131236 3985 22330411 YGL099W LSG1 SGTC_2298 7976326 193.81 µM -0.869923669969549 0.196599649641205 no 2737 0.192171059551939 3797 2235818 SGTC_1649 st011737 51.3 µM -0.870417741358934 0.19646834698551 no 2738 0.192036077346863 3918 1761035 SGTC_3196 9111891 49.47 µM -0.871491795331539 0.196183093611701 no 2739 0.191742841894331 3924 18891510 SGTC_1216 1165-0504 9.65 µM -0.871980244667865 0.1960534515731 no 2740 0.191609577461183 3938 6304004 SGTC_2963 9082507 9 µM -0.872865347524167 0.195818663967115 no 2741 0.191368237986376 3991 16459611 SGTC_9 0092-0002 10.449 µM -0.873366514914167 0.195685797045368 no 2742 0.191231668177164 3899 759368 SGTC_868 0527-0199 213 µM -0.873495805001751 0.195651529204575 no 2743 0.191196445888189 3890 2849450 SGTC_457 grayanotoxin iii 135 µM -0.875742491927776 0.195056635334729 no 2744 0.190585019833929 3827 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1694 st024011 44.9 µM -0.876365310639999 0.194891915796306 no 2745 0.190415735165086 3957 2787533 SGTC_2167 5876490 200 µM -0.87714856586926 0.194684885047782 no 2746 0.190202974328343 4086 686534 SGTC_1892 st058411 7.36 µM -0.878680616751109 0.194280318949517 no 2747 0.189787235605855 3975 3934738 SGTC_1370 2001-0092 44.6 µM -0.879671724479064 0.194018871725713 no 2748 0.189518585631223 4005 790957 SGTC_3332 9141069 11.198 µM -0.881114394696884 0.193638688850053 no 2749 0.189127953423934 3876 17332883 SGTC_1932 st074806 40.9 µM -0.88271115468212 0.193218429202974 no 2750 0.188696176870071 4032 17251235 SGTC_2975 9084847 53.72 µM -0.886520662273986 0.192218035751081 no 2751 0.187668512503208 4025 27211724 SGTC_883 0850-0245 24.6 µM -0.886642283719164 0.192186149703685 no 2752 0.187635760588495 4034 6823229 YPR165W RHO1 SGTC_1905 st060207 84.5 µM -0.888288896668582 0.191754768227938 no 2753 0.187192685367339 3898 1948547 SGTC_2900 5328528 85.29 µM -0.888598781745755 0.191673650534312 no 2754 0.187109373021446 3974 795359 SGTC_1612 st002233 45.4 µM -0.888627525616228 0.191666127402187 no 2755 0.187101646418194 3943 1035021 SGTC_3098 9119039 49.47 µM -0.889286109813297 0.19149380572907 no 2756 0.186924667304117 3942 17161528 SGTC_736 0958-0254 92.6 µM -0.889820525045994 0.191354043241013 no 2757 0.186781131854816 4049 6812352 SGTC_2123 5259487 200 µM -0.891104566034137 0.191018491160261 no 2758 0.186436537795 3981 2173474 SGTC_1346 1488-2224 62.4 µM -0.892775082550802 0.190582483881179 no 2759 0.185988816348893 3935 3722427 SGTC_1253 0550-0034 176 µM -0.893000389152484 0.190523725317611 no 2760 0.185928482133595 3981 5969915 SGTC_684 1140-0066 328 µM -0.893225368957679 0.190465063080314 no 2761 0.18586824754176 4031 6813534 SGTC_1432 4049-0298 68.4 µM -0.893672994184577 0.190348380273828 no 2762 0.185748439347805 3982 741646 SGTC_898 1000-0849 28.3 µM -0.89587244433759 0.189775686055954 no 2763 0.185160446376244 3951 6751807 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.900334760032293 0.188617045543746 no 2764 0.18397106405862 3909 5711223 A potent inhibitor of glutathione S-transferases. SGTC_389 tpck 16.7 µM -0.9008886727276 0.188473526977639 no 2765 0.183823757209938 3982 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2200 6600604 21.907 µM -0.90206593002932 0.1881687238118 no 2766 0.183510922963873 3934 2904777 SGTC_1904 st060225 78 µM -0.902921037508435 0.187947519148947 no 2767 0.183283902222584 3913 66595 SGTC_2736 butenafine 14.65 µM -0.903854416073697 0.187706250171606 no 2768 0.183036301456025 3921 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2873 9040596 71.43 µM -0.904610372130617 0.187510983422087 no 2769 0.182835919244605 3974 6463863 SGTC_534 k292-0788 63.4 µM -0.905802584917035 0.187203284866157 no 2770 0.182520176300188 3978 4146317 SGTC_590 k048-0076 22.4 µM -0.909975369796392 0.186128790591315 no 2771 0.181417749654748 3999 6832814 SGTC_2281 7943571 200 µM -0.912249492804039 0.185544815358326 no 2772 0.180818697739109 4086 1244024 SGTC_83 0170-0301 39.027 µM -0.913735522520116 0.185163830671729 no 2773 0.180427916851018 3916 3089716 SGTC_268 camptothecin 39.6153 µM -0.914227390620469 0.185037833826876 no 2774 0.18029868720731 3958 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_362 0310-0100 9.03 µM -0.916406501459911 0.184480274136055 no 2775 0.179726863305727 4071 790235 SGTC_3336 9143619 71.43 µM -0.917485645402583 0.184204545535941 no 2776 0.179444105769372 4017 45595730 SGTC_1722 st034304 3.6505 µM -0.919047844321677 0.183805847778626 no 2777 0.179035273809829 3992 4036148 YLR033W RSC58 SGTC_1267 0828-0272 9.49 µM -0.919838662462127 0.183604223624957 no 2778 0.178828538031433 4082 745334 SGTC_1230 0170-0365 3.77 µM -0.921725087868449 0.183123824155605 no 2779 0.178335995501902 4056 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.924047783179207 0.182533401797476 no 2780 0.177730719043781 4046 521171 SGTC_281 1672-3440 14.9 µM -0.92725269973921 0.181720675975551 no 2781 0.176897673299752 4044 6833000 SGTC_2983 9022671 12.99 µM -0.929403063952263 0.181176642307844 no 2782 0.176340120269546 4025 6405161 SGTC_2950 9072895 21.46 µM -0.930671376023222 0.180856243172326 no 2783 0.176011790315593 3966 17332245 SGTC_1233 0325-0408 14.2 µM -0.932036583422104 0.180511763622413 no 2784 0.175658809758847 4044 12874 SGTC_2277 7947813 106.88 µM -0.937256265477729 0.179198491999972 no 2785 0.17431337682515 4093 1246798 SGTC_2746 daunorubicin 9.88 µM -0.939849683988343 0.178548228496944 no 2786 0.173647334804314 3929 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2903 5923464 63.88 µM -0.940779659514193 0.178315412578457 no 2787 0.1734088933296 4026 2876576 SGTC_946 3434-1334 87.4 µM -0.941185149392465 0.178213959609162 no 2788 0.173304992858173 4017 4047976 SGTC_1641 st009299 47.1 µM -0.944797730247609 0.177311703679354 no 2789 0.172381075440355 3929 4046054 SGTC_2766 oltipraz 83.91 µM -0.945428075808337 0.177154568519821 no 2790 0.172220187122977 3978 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_140 0062-0056 502.533 µM -0.945860070464493 0.177046929911563 no 2791 0.172109980904118 3964 3758964 SGTC_2468 5987765 72.9 µM -0.948020363411727 0.176509277381416 no 2792 0.171559543812479 4082 26772094 SGTC_2387 9077560 195.08 µM -0.949767401846553 0.176075231513082 no 2793 0.171115226504743 4005 5303272 SGTC_3060 1327-0027 12.5 µM -0.950212819755329 0.175964677110082 no 2794 0.171002062988065 3932 16000455 YPR107C YTH1 SGTC_2563 tomatine 8.54 µM -0.951031105325155 0.175761690126108 no 2795 0.170794292969227 3912 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2451 5856223 45.7 µM -0.951542912478694 0.175634804761011 no 2796 0.1706644227186 4010 2179896 SGTC_2292 7671323 168.05 µM -0.953004828171472 0.175272691724365 no 2797 0.17029381220988 4100 937504 SGTC_2661 dactinomycin 12.96 µM -0.956802344024139 0.17433427013429 no 2798 0.169333514459122 4017 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3338 9144300 39.5675 µM -0.960513514281525 0.173420276012548 no 2799 0.168398416356024 4057 4901274 SGTC_2881 9058953 51.95 µM -0.96225875434106 0.172991511372379 no 2800 0.167959821019771 3997 17122249 SGTC_1743 st037606 46.3785 µM -0.962306662292126 0.172979751042173 no 2801 0.16794779167641 4012 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1330 1469-0054 61.8 µM -0.962755637061734 0.1728695625367 no 2802 0.167835084279459 4046 7102664 SGTC_2521 angolensin 13.4 µM -0.96330149708719 0.172735656474419 no 2803 0.1676981211126 4108 821428 A flavenoid. SGTC_2625 euphol 100 µM -0.964254214471029 0.172502101836873 no 2804 0.167459244801324 4094 6708538 A triterpene alcohol. SGTC_2718 lomofungin 53.02 µM -0.965725698294953 0.172141769738948 no 2805 0.167090728396925 4033 5351222 A RNA synthesis inhibitor. SGTC_3082 9117008 49.47 µM -0.966471415075472 0.171959344617809 no 2806 0.166904171898845 4120 41448529 SGTC_1085 doxorubicin 7.67 µM -0.970311214745542 0.171021967216476 no 2807 0.165945694450496 4077 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1166 k206-0078 225 µM -0.970681020030812 0.170931862695456 no 2808 0.165853573101327 4049 5404595 SGTC_229 benomyl 22.8748 µM -0.970855006700776 0.170889480663142 no 2809 0.165810243116494 4070 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1362 1611-0397 101 µM -0.972375684364593 0.170519339618593 no 2810 0.165431842064414 4024 27816 SGTC_686 1319-0111 510 µM -0.972941717904302 0.170381695243495 no 2811 0.165291134696973 4098 4562600 SGTC_783 0848-0141 92.7 µM -0.973980355384784 0.170129311253589 no 2812 0.165033146641362 3994 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_54 0159-0055 9 µM -0.974352923437318 0.170038837393566 no 2813 0.164940667709184 4061 3319099 SGTC_3041 9091929 49.47 µM -0.976511056098365 0.169515366579406 no 2814 0.164405635851581 4067 25236887 SGTC_1111 tnp00062 510.699 nM -0.977647938524468 0.16924002372894 no 2815 0.164124239445338 4107 676306 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.978475446349242 0.16903978932305 no 2816 0.163919614720377 4081 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1007 4101-0031 70 µM -0.979247108664006 0.168853205167642 no 2817 0.163728948606459 4031 1146276 SGTC_582 0987-0078 156 µM -0.979541362186275 0.168782090974325 no 2818 0.163656280931555 4097 1625765 SGTC_3159 9100096 49.47 µM -0.979720048640283 0.168738916031538 no 2819 0.163612163458271 4011 25236875 SGTC_43 0570-0105 72.5 µM -0.980252245656468 0.168610366492863 no 2820 0.16348081040069 4068 1114046 YDL195W SEC31 SGTC_2182 6325192 200 µM -0.980305089411137 0.168597605783685 no 2821 0.163467771622327 3987 736248 SGTC_1927 st060202 13.8 µM -0.985413183196799 0.167367034235975 no 2822 0.162210578333821 3948 688887 SGTC_992 3909-8734 162 µM -0.987372317102235 0.166896606263793 no 2823 0.161730075126534 4089 4288319 SGTC_3190 9110366 49.47 µM -0.987433050266553 0.16688203663633 no 2824 0.161715194362862 4071 17123768 SGTC_393 acivicin 6.25 µM -0.988029223715044 0.166739060722082 no 2825 0.16156916806722 3920 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_781 4335-2806 94.4 µM -0.99007593992954 0.166248813403061 no 2826 0.16106850122244 4151 845254 SGTC_563 tetrahydrosecaminediol 614 µM -0.993697072032212 0.165383731354898 no 2827 0.160185184320056 4144 334274 A psychoactive constituent of the cannabis plant. SGTC_116 0155-0182 31.788 µM -0.9968934377249 0.164622549711658 no 2828 0.159408118651012 3993 771486 SGTC_210 3551-0445 56.827 µM -0.998117166592273 0.164331733138043 no 2829 0.159111273395587 4133 2865180 YOR207C RET1 SGTC_2222 6885208 172.143 µM -0.998499331833573 0.164240980673771 no 2830 0.159018644154482 4033 609514 SGTC_379 3970-0972 5.9 µM -0.998612462705815 0.164214121814644 no 2831 0.158991230264001 4080 2898042 YBL034C STU1 SGTC_1035 k081-0041 55.2 µM -0.999260856430625 0.164060238981232 no 2832 0.158834171134778 4120 731709 SGTC_1027 k015-0025 8.67 µM -0.999527818464007 0.163996908261974 no 2833 0.158769535014165 4054 3598955 SGTC_1388 3346-4487 254 µM -0.999982039608327 0.163889190999912 no 2834 0.15865959985947 4141 3345614 SGTC_487 nimodipine 119 µM -1.00017560286242 0.163843301975313 no 2835 0.158612766910359 4029 4497 L-type voltage-gated calcium channels inhibitor SGTC_1170 0310-0127 64.8 µM -1.00077130972237 0.163702127049516 no 2836 0.158468691535553 4111 774975 SGTC_3281 9140613 49.47 µM -1.00336054500003 0.163089429159232 no 2837 0.157843466739929 4097 16013766 SGTC_2164 5685496 200 µM -1.0053534988087 0.162618847459209 no 2838 0.15736333136383 4001 759046 SGTC_685 1278-0033 54.9 µM -1.00637867455835 0.162377124576011 no 2839 0.157116723984373 4151 3590572 SGTC_3016 9080866 49.47 µM -1.00646645562504 0.162356437836742 no 2840 0.157095619952357 4079 17066299 SGTC_380 3970-0968 6 µM -1.00653103130456 0.16234122084113 no 2841 0.157080096072592 3980 2891601 SGTC_807 1315-0151 48 µM -1.01012610934161 0.161495519996674 no 2842 0.156217437313944 4134 4011080 SGTC_1291 0993-0025 5.79 µM -1.01387896784113 0.160615773089647 no 2843 0.155320254177208 4119 4353356 SGTC_1751 st044839 27.194 µM -1.0142792994699 0.160522112266555 no 2844 0.155224749378175 4120 5291326 SGTC_817 1391-0715 46 µM -1.01566647955511 0.160197846338017 no 2845 0.154894117787696 4100 1353946 SGTC_2418 pentamidine 31.67 µM -1.01947560840954 0.159309631725363 no 2846 0.15398861363056 4068 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2322 7413319 38.22 µM -1.02256770633343 0.158590990731455 no 2847 0.153256142483384 4149 1840400 SGTC_3128 9127691 49.47 µM -1.02310261101223 0.158466888426794 no 2848 0.153129666283533 4164 41316314 SGTC_2842 9000675 19.48 µM -1.02321470393554 0.158440890017628 no 2849 0.153103171103065 4166 2989072 SGTC_2821 7996764 71.43 µM -1.02332213374022 0.15841597578044 no 2850 0.153077780986341 4173 2987135 SGTC_33 0986-0033 35.816 µM -1.02834382441024 0.157254254415595 no 2851 0.151894061562629 4075 2848082 SGTC_885 0865-0106 16.8 µM -1.02853241677886 0.157210734734558 no 2852 0.15184972512366 4052 2793380 SGTC_146 3448-8650 53.125 µM -1.03130349522538 0.156572192258851 no 2853 0.151199259895527 4105 2891488 YIL048W NEO1 SGTC_2217 6934799 96.0675 µM -1.0350105987918 0.155720634292424 no 2854 0.150331980739407 4094 675606 SGTC_696 1560-0013 611 µM -1.03530894866181 0.155652233450524 no 2855 0.150262326020701 4190 1650269 SGTC_1409 3909-8004 61.9 µM -1.03749716205405 0.155151160943575 no 2856 0.149752108818235 4140 2119279 SGTC_3038 9091290 49.47 µM -1.0378425250501 0.15507217470106 no 2857 0.149671687592628 4160 25236843 SGTC_622 1348-1566 26.3 µM -1.03906493133134 0.154792817614527 no 2858 0.149387269601541 4155 7340407 SGTC_2730 imipramine 71.33 µM -1.04083105922429 0.15438979110545 no 2859 0.148976981188412 4103 3696 A tricyclic antidepressant. SGTC_1827 berberine 7.24 µM -1.04111460007009 0.154325152396786 no 2860 0.148911182135769 4057 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_644 1498-1197 63.3 µM -1.04262920910631 0.153980170640774 no 2861 0.148560027893038 4170 6741615 SGTC_2309 7664088 163.95 µM -1.04432735465175 0.153593992096448 no 2862 0.148166980540668 4159 704922 SGTC_2329 6138490 200 µM -1.04509224314053 0.153420257010258 no 2863 0.14799016938534 4253 720019 SGTC_2918 7977171 22.06 µM -1.04573183570293 0.15327508133745 no 2864 0.147842430023195 4117 2236483 SGTC_1672 st016598 6.51 µM -1.04732068357338 0.152914836308469 no 2865 0.14747584983441 4145 4665860 YNL267W PIK1 SGTC_1728 st035614 33.7865 µM -1.04820665923509 0.152714199951187 no 2866 0.14727170155395 4104 15945546 SGTC_112 phenothiazine 287.218 µM -1.04821180833578 0.152713034406269 no 2867 0.147270515641778 4090 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1046 2001-0062 216 µM -1.04872522951903 0.152596846563463 no 2868 0.147152299474029 4049 739778 SGTC_445 e6 berbamine 66 µM -1.04985458370687 0.15234147876754 no 2869 0.146892487536722 4163 6610268 A calcium/calmodulin antagonist. SGTC_2053 5265679 138 µM -1.04999748847788 0.152309185595079 no 2870 0.146859633730738 4060 764595 SGTC_2168 5727979 200 µM -1.05065165776606 0.152161416484846 no 2871 0.146709303143709 4035 695210 SGTC_2859 9028643 45.46 µM -1.05096378166015 0.15209094494367 no 2872 0.146637612285367 4008 17151580 SGTC_2213 7173844 200 µM -1.05308666099849 0.151612214942319 no 2873 0.146150637873993 4096 892728 SGTC_2797 7859098 81.82 µM -1.05605929507792 0.15094354201314 no 2874 0.145470562824324 4144 972681 SGTC_2888 9058547 12.99 µM -1.05705678413642 0.150719604432099 no 2875 0.145242836356577 4050 16476514 SGTC_808 0711-0032 135 µM -1.05718560503358 0.150690700112138 no 2876 0.145213444081057 4105 4252555 SGTC_14 0354-0009 295 µM -1.05735090482918 0.15065361620954 no 2877 0.145175734501803 4236 1713507 SGTC_2311 7694451 200 µM -1.05941139590237 0.15019186888822 no 2878 0.144706230990823 4138 2163142 SGTC_317 4495-0002 170 µM -1.0611653489291 0.149799559448758 no 2879 0.144307381887461 4170 15991618 SGTC_2587 piperic acid 92.2 µM -1.06210468620403 0.149589737708336 no 2880 0.144094081462851 4153 5370536 SGTC_2032 5185112 25.99 µM -1.06214199894865 0.149581407133981 no 2881 0.144085613047373 4032 5718189 SGTC_1139 k015-0024 46.9 µM -1.06230469677537 0.149545086264064 no 2882 0.14404869144156 4174 2766652 SGTC_723 4182-0001 115 µM -1.06445023526758 0.149066664114066 no 2883 0.143562393483033 4178 744821 YLR208W SEC13 SGTC_3248 9135562 49.47 µM -1.06528206857887 0.148881453382129 no 2884 0.143374152383853 4134 17650701 SGTC_1825 st052143 62.6 µM -1.06552207836603 0.148828042920415 no 2885 0.143319869965874 4218 674173 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.0673090553484 0.148430781471913 no 2886 0.142916150179625 4207 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2380 9035439 200 µM -1.06907966548253 0.148037858604342 no 2887 0.142516886773771 4265 6462575 SGTC_507 nimesulide 162 µM -1.06951311456895 0.14794177642499 no 2888 0.142419261303558 4224 4495 A COX2 inhibitor. SGTC_1930 st074634 34.3 µM -1.06994844950846 0.147845318237322 no 2889 0.142321256626205 4068 684253 YOR116C RPO31 SGTC_2308 7584454 197.62 µM -1.07143580368389 0.147516079418875 no 2890 0.141986760678637 4226 893577 SGTC_839 0122-0028 230 µM -1.0761711793734 0.146471136191903 no 2891 0.140925353338234 4159 759448 SGTC_3160 9100216 49.47 µM -1.08021574861564 0.14558257511214 no 2892 0.140023058501119 4134 17191039 SGTC_2486 5283202 22.39 µM -1.08107332181408 0.145394639525511 no 2893 0.139832249734576 4225 1377751 SGTC_2246 7293507 91.5585 µM -1.08165038663972 0.14526826872511 no 2894 0.139703953188715 4220 887656 SGTC_3104 9120930 49.47 µM -1.08213776049605 0.145161596832506 no 2895 0.139595659640821 4203 17014836 SGTC_2816 7982706 58.44 µM -1.08269946205212 0.145038722178203 no 2896 0.139470921444206 4205 2981853 SGTC_930 2810-3379 265 µM -1.08398092251316 0.144758659254285 no 2897 0.139186628788835 4222 1015764 SGTC_1854 st056233 32.9 µM -1.0845123044182 0.144642632740887 no 2898 0.139068857196471 4108 5393174 SGTC_181 1447-1644 8.07 µM -1.08601517440281 0.144314822335243 no 2899 0.138736139399687 4174 534600 SGTC_1562 morin hydrate 59.1 µM -1.08721151589991 0.144054231061086 no 2900 0.138471671303926 4238 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3271 9137798 49.47 µM -1.08746851804058 0.14399829139129 no 2901 0.138414902228804 4121 6498326 SGTC_1972 st070201 17.4 µM -1.08811204995356 0.14385828305188 no 2902 0.1382728223768 4184 2829099 SGTC_1868 st057644 42.7 µM -1.09412723111596 0.142554047242513 no 2903 0.136949590432783 4202 688665 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.09679064285009 0.141979117694844 no 2904 0.136366460767903 4215 4174840 SGTC_1681 tripelennamine 100 µM -1.09963621372078 0.141366603646924 no 2905 0.135745328436513 4137 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2621 lithochol-11-enic acid 100 µM -1.10000804660458 0.141286698481847 no 2906 0.135664307983814 4156 6708711 SGTC_3342 9147791 14.508 µM -1.10310680159919 0.140621981200271 no 2907 0.134990393740047 4117 1838168 SGTC_2916 7875993 68.79 µM -1.10330193511346 0.140580194056962 no 2908 0.134948033273234 4030 1299250 SGTC_998 3996-0085 177 µM -1.10858678181206 0.139451667948677 no 2909 0.133804241481176 4233 715391 SGTC_3320 9137005 35.139 µM -1.1097106341008 0.139212477322679 no 2910 0.133561869500356 4235 4908713 SGTC_2480 5767542 37.17 µM -1.11048314856505 0.139048224289048 no 2911 0.133395442853814 4149 2867358 SGTC_2743 auranofin 4.32 µM -1.11172626502107 0.138784188292844 no 2912 0.133127931656716 4191 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_812 4251-0442 148 µM -1.11252913828239 0.138613840865042 no 2913 0.132955354515706 4242 5723007 SGTC_2029 5175081 200 µM -1.11591819017646 0.137896348212932 no 2914 0.132228577378387 4171 1380876 SGTC_2744 captopril 92.04 µM -1.11601032848263 0.13787687714916 no 2915 0.1322088567714 4257 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1224 0823-0416 294 µM -1.11775034181439 0.137509522188283 no 2916 0.131836817762801 4279 3598164 SGTC_2550 chrysin dimethyl ether 71.87 µM -1.12041767760949 0.136947687386252 no 2917 0.131267907645889 4054 88881 An O-methylated flavonoid and antioxidant. SGTC_1359 1582-0056 520 nM -1.12052805026118 0.136924472869801 no 2918 0.131244403093278 4265 3661189 SGTC_2257 7960413 200 µM -1.12628765128934 0.135716795370369 no 2919 0.130021891487542 4242 2974689 YIL048W NEO1 SGTC_2173 5763948 167 µM -1.1263707233329 0.135699430303313 no 2920 0.130004316776893 4199 2867177 SGTC_907 3448-6986 75.5 µM -1.12731560905632 0.135502022054616 no 2921 0.129804532591915 4262 590582 SGTC_3176 9106582 49.47 µM -1.12848841567284 0.13525726974535 no 2922 0.129556853238358 4179 17018027 SGTC_823 0417-1665 178 µM -1.13958998085578 0.132955501821647 no 2923 0.127228580706615 4218 3429856 SGTC_1141 3253-0389 52.6 µM -1.14000637955439 0.132869694765871 no 2924 0.127141821656754 4232 5402031 SGTC_1831 st055328 12 µM -1.14070599188921 0.132725611898002 no 2925 0.126996146129561 4227 1103068 SGTC_1117 retinoic acid 1.10837 µM -1.14070923234003 0.13272494478824 no 2926 0.126995471662877 4271 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_960 1222-0186 7.7 µM -1.14171282640595 0.132518446558311 no 2927 0.12678670377001 4251 3126296 SGTC_2130 NSC 7 2.4545 µM -1.14206364539835 0.132446314733918 no 2928 0.126713782709295 4305 21448 SGTC_996 3970-0799 1.8 µM -1.14441694779602 0.131963152174842 no 2929 0.126225381486445 4233 6615648 YGL040C HEM2 SGTC_3021 9087658 49.47 µM -1.14497272896341 0.131849220994875 no 2930 0.126110227186554 4234 25237042 SGTC_101 0490-5701 117.494 µM -1.14899356154638 0.131027000214958 no 2931 0.125279317771314 4049 4661669 SGTC_1490 4089-0339 670 nM -1.14952527106861 0.130918536622806 no 2932 0.125169726229646 4206 742542 SGTC_1856 st057054 55.7 µM -1.15102369037373 0.130613207459076 no 2933 0.124861244739692 4258 1266018 SGTC_3224 9130643 49.47 µM -1.15337537776198 0.130135003373124 no 2934 0.12437817161158 4325 17644395 SGTC_742 0kpi-0133 140 µM -1.15791920226278 0.129214474371779 no 2935 0.123448505256829 4279 2728852 SGTC_1508 1080-0625 72.9 µM -1.15796774027858 0.129204665529552 no 2936 0.12343860072664 4152 767111 SGTC_29 0299-0004 12.984 µM -1.16022310719476 0.128749457097696 no 2937 0.122978990687058 4148 16871 A napthoquinone isolated from Swertia calycina. SGTC_773 4358-1457 44.6 µM -1.16137759106302 0.128516874715515 no 2938 0.122744188966286 4265 1186886 SGTC_825 1988-2224 89.6 µM -1.16200878715343 0.128389837294336 no 2939 0.12261594781121 4236 1180859 SGTC_3228 9131799 49.47 µM -1.1626696503262 0.128256922389185 no 2940 0.122481779903046 4263 17015818 SGTC_1686 st019653 115.5 µM -1.16659482126986 0.127469448727731 no 2941 0.121687017858327 4250 97252 SGTC_1411 3909-8223 150 µM -1.16768401607516 0.127251530033072 no 2942 0.121467123274983 4276 X1411 SGTC_199 4063-0024 41.6 µM -1.16947340275581 0.126894084606952 no 2943 0.121106475561431 4270 306215 SGTC_999 SEC7.066 22.7 µM -1.17177759716439 0.126434832238324 no 2944 0.120643179674262 4215 740511 YDR170C SEC7 SGTC_3048 9093155 49.47 µM -1.17265376377029 0.126260506441791 no 2945 0.120467339946889 4240 25236002 SGTC_829 1635-0120 117 µM -1.17300782898662 0.126190107681684 no 2946 0.120396333082537 4266 285054 SGTC_1308 1187-1617 41.4 µM -1.17303677806166 0.126184352949459 no 2947 0.120390528724288 4285 2882570 SGTC_3124 9127567 49.47 µM -1.17622914165973 0.125550871022816 no 2948 0.119751661149874 4251 17592030 SGTC_2426 5582046 32.21 µM -1.17720196224592 0.12535826971299 no 2949 0.119557452827492 4278 2251934 SGTC_724 3910-0327 137 µM -1.17747247928102 0.125304748783873 no 2950 0.119503487860591 4311 2885483 SGTC_1300 1094-0077 113 µM -1.17849612883038 0.12510236740451 no 2951 0.119299437366455 4232 5532636 SGTC_2525 harmine 47.85 µM -1.17955125186314 0.124894002572701 no 2952 0.119089370537853 4252 5280953 A monoamine oxidase inhibitor SGTC_2753 fluvastatin 17.09 µM -1.18107181127203 0.124594150431835 no 2953 0.118787098491631 4275 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_929 2805-0021 398 µM -1.18158906432171 0.124492263674276 no 2954 0.118684397386039 4336 3098024 SGTC_2493 resveratrol 26.09 µM -1.18565346841077 0.123693698156414 no 2955 0.117879588768183 4193 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_133 0724-0033 378.92 µM -1.18568247106652 0.123688012693677 no 2956 0.117873859747515 4094 280309 SGTC_1126 isoteolin 1.0172 µM -1.1860795160242 0.123610197381537 no 2957 0.117795449539604 4209 133323 SGTC_951 1171-0579 82.7 µM -1.18661277044619 0.12350574085211 no 2958 0.117690198164701 4228 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2703 st077852 53.4 µM -1.18805812059356 0.123222929414697 no 2959 0.117405256162054 4301 6281836 SGTC_1115 galangin 695.678 nM -1.18992911196537 0.122857507227331 no 2960 0.117037127562628 4351 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_448 monastrol 171 µM -1.19026483739908 0.122792017391768 no 2961 0.116971158246385 4196 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1703 st026983 48.3 µM -1.19060488522627 0.122725709350106 no 2962 0.116904366456625 4306 1104023 SGTC_1588 farnesol 29.9 µM -1.19303477691981 0.122252620550528 no 2963 0.116427876674083 4291 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_481 bay k-8644 50 µM -1.19530700617539 0.121811387577802 no 2964 0.115983551717544 4250 2303 A calcium channel antagonist. SGTC_2037 5169046 200 µM -1.19533156428948 0.121806624878297 no 2965 0.115978756065503 4329 5718022 SGTC_2235 salicylic acid 500 µM -1.20216077399659 0.120487269426825 no 2966 0.114650621885927 4318 338 A COX inhibitor and kinase inhibitor. SGTC_911 3456-4043 236 µM -1.20795273826962 0.119376215962477 no 2967 0.113532721027931 4285 914281 SGTC_584 0986-0246 15.4 µM -1.20941881031893 0.119096134408026 no 2968 0.113250992797131 4390 53315 YDR232W HEM1 SGTC_655 k060-0012 42 µM -1.20976347315758 0.119030356686798 no 2969 0.113184833014587 4277 5994525 SGTC_788 1182-0090 188 µM -1.21190042231472 0.11862309980901 no 2970 0.112775250241072 4303 5715185 SGTC_561 1550-0330 72.9 µM -1.21358803520238 0.118302173361195 no 2971 0.112452539121184 4241 6812934 SGTC_3215 9129942 49.47 µM -1.21415009794641 0.118195424576712 no 2972 0.112345206147567 4278 17682944 SGTC_3105 9121040 49.47 µM -1.22060405098106 0.116974548441292 no 2973 0.111117985901465 4204 41448907 SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.22258510073608 0.116601597780704 no 2974 0.110743221691077 4305 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2010 4012422 159 µM -1.22378939900192 0.116375290197886 no 2975 0.110515842220815 4248 952393 SGTC_851 0394-0702 453 µM -1.22521127616137 0.116108497294025 no 2976 0.110247813486765 4310 762646 SGTC_2373 9071805 200 µM -1.22569806521759 0.116017258807391 no 2977 0.110156159288888 4317 10149009 SGTC_2929 9013348 24.6 µM -1.22603200650956 0.115954697896682 no 2978 0.110093315372725 4296 2995952 SGTC_1 0258-0098 57.368 µM -1.22710925952655 0.115753047453442 no 2979 0.109890764048088 4248 6790032 YDR047W HEM12 SGTC_2603 homopterocarpin 100 µM -1.22898511162932 0.115402502352039 no 2980 0.109538694094981 4293 101795 A weak amylase inhibitor. SGTC_1780 st038448 24.544 µM -1.23238364000507 0.114769333904247 no 2981 0.108902904626434 4343 728868 YDL195W SEC31 SGTC_182 3448-4371 550.524 µM -1.23400054341054 0.114468963282967 no 2982 0.108601350876029 4184 3491403 SGTC_2221 6807166 181.081 µM -1.23495292083887 0.114292303122977 no 2983 0.108424013056211 4274 674925 SGTC_1911 st060208 74.3 µM -1.23538197590728 0.114212779508849 no 2984 0.108344188799001 4356 688783 SGTC_1861 st057647 17.4 µM -1.23594914371788 0.114107717744753 no 2985 0.108238734042964 4383 688668 SGTC_2485 5633444 17.78 µM -1.23756268521462 0.113809203013097 no 2986 0.107939128828008 4318 5724239 SGTC_2267 7931562 200 µM -1.243797498019 0.112660957015163 no 2987 0.106787050733053 4257 934880 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.24450508828855 0.112531166944806 no 2988 0.106656863916544 4298 364106 SGTC_2043 5101342 149 µM -1.24884473024747 0.111737502014553 no 2989 0.105860935014581 4343 678451 SGTC_845 0330-0138 4.51 µM -1.25103006645788 0.11133935132758 no 2990 0.105461754075091 4275 9039800 SGTC_2056 5235370 200 µM -1.25251525025593 0.11106934303357 no 2991 0.105191087439115 4240 5511916 SGTC_2761 levamisole 97.89 µM -1.25678594091211 0.11029553989086 no 2992 0.104415579140195 4340 26879 An alkaline phosphatase inhibitor. SGTC_1732 st034308 51.822 µM -1.25694679002378 0.110266471501414 no 2993 0.104386451962841 4199 830119 SGTC_2650 prasterone 100 µM -1.2580006250863 0.110076160058199 no 2994 0.104195765092432 4323 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2331 7980721 200 µM -1.261307292326 0.10948054100539 no 2995 0.103599077446 4289 2981221 SGTC_1760 st045453 10.4495 µM -1.26248175038418 0.109269547802461 no 2996 0.103387744527587 4380 3323419 YIL048W NEO1 SGTC_222 nsc-310342 10.666 µM -1.26547420786682 0.108733269061862 no 2997 0.102850694230467 4357 432556 SGTC_535 2293-4129 48.2 µM -1.26640039897848 0.108567670416527 no 2998 0.102684884080715 4340 396118 YIL048W NEO1 SGTC_1226 3909-7979 35.4 µM -1.27529296317388 0.106986948142202 no 2999 0.101102783740081 4342 6615510 SGTC_3109 9122853 49.47 µM -1.27666193834066 0.106745084362384 no 3000 0.100860812234458 4373 1234709 SGTC_3066 9117245 49.47 µM -1.27674918902967 0.106729682727406 no 3001 0.100845404673244 4380 17176980 SGTC_49 0717-0965 32.132 µM -1.27718183396678 0.106653335224066 no 3002 0.100769029445616 4414 5889349 YGL099W LSG1 SGTC_560 2332-1943 155 µM -1.28201182117221 0.105803677726275 no 3003 0.0999192497252091 4340 21177716 SGTC_2088 5278280 127.392 µM -1.28393238588567 0.105467188597821 no 3004 0.0995828071772923 4394 791502 SGTC_1272 0839-0021 27 µM -1.28443284756347 0.105379633359867 no 3005 0.099495272939575 4370 5027250 SGTC_2552 juarezic acid 87.02 µM -1.28472776961561 0.105328061689266 no 3006 0.0994437153577923 4298 1549512 SGTC_23 0213-0011 39.996 µM -1.2853416255303 0.105220778071211 no 3007 0.0993364651361917 4352 627608 SGTC_1974 st069448 26.9 µM -1.28696652787202 0.104937175553353 no 3008 0.0990529775371615 4343 6323587 YNR016C ACC1 SGTC_2436 5633522 8.09 µM -1.2875504632742 0.104835393607848 no 3009 0.0989512462779289 4342 5724242 SGTC_1055 3448-0672 86 µM -1.2916808854977 0.104117487360406 no 3010 0.0982338398261221 4331 748378 SGTC_2143 5623677 140.463 µM -1.29233665393041 0.104003837277967 no 3011 0.0981202918010303 4290 5375313 SGTC_1739 st037196 92.5 µM -1.29700092058454 0.103198075964515 no 3012 0.0973154350241981 4398 612214 SGTC_409 arachidonic acid 100 µM -1.29714354119986 0.103173509595201 no 3013 0.097290901234314 4349 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2491 paeonol 100 µM -1.29757565935487 0.103099103265701 no 3014 0.0972165953932147 4301 11092 Increases levels of cortical cytochrome oxidase. SGTC_2394 5221648 200 µM -1.29839186443866 0.102958667436105 no 3015 0.0970763566590596 4392 788586 SGTC_234 nsc-17383 10.7 µM -1.29948477804118 0.102770838974973 no 3016 0.0968888070187532 4373 408974 SGTC_2583 asiatic acid 100 µM -1.29958228233302 0.102754093964532 no 3017 0.0968720877116623 4385 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2949 9072542 2.23 µM -1.30133198835366 0.102453943175591 no 3018 0.0965724211968279 4370 16457352 SGTC_2749 bexarotene 57.39 µM -1.30168602092265 0.102393288793715 no 3019 0.0965118701028282 4382 82146 An retinoic acid receptor inhibitor. SGTC_2651 TUB2.036 5 µM -1.30401186778016 0.101995463879398 no 3020 0.0961147680015881 4294 15992207 YFL037W TUB2 SGTC_1405 3909-7894 12 µM -1.30652050501438 0.10156763567527 no 3021 0.0956878052858026 4344 7104060 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.30814568669279 0.101291172262387 no 3022 0.0954119499662671 4369 1377 SGTC_2920 7982904 15.77 µM -1.31430503894927 0.100248367375982 no 3023 0.0943717861185484 4383 6456808 SGTC_1246 0422-0085 105 µM -1.31454437402128 0.100208005671409 no 3024 0.0943315377343456 4395 264295 SGTC_1970 st070122 35.8 µM -1.31637006820762 0.0999005091032581 no 3025 0.0940249318103846 4383 102928 SGTC_1322 1348-1070 12 µM -1.31645268930491 0.0998866097802791 no 3026 0.0940110738881577 4372 6758089 SGTC_263 alizarin 107.927 µM -1.31672681671305 0.0998405035242919 no 3027 0.0939651056735092 4417 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_65 0798-0905 34.986 µM -1.31689866051549 0.099811608562212 no 3028 0.0939362977776227 4419 3602145 SGTC_2458 5808907 16.39 µM -1.31940835144924 0.0993903082612183 no 3029 0.0935163156243092 4514 2731747 SGTC_1336 1486-0901 104 µM -1.32267203934481 0.0988443813678827 no 3030 0.0929722329066257 4384 5006114 SGTC_1213 1315-0166 115 µM -1.32358539212124 0.0986919957718412 no 3031 0.0928203896333185 4393 768401 SGTC_2219 9098279 200 µM -1.32362635614993 0.0986851652828017 no 3032 0.0928135837356235 4322 902349 SGTC_2799 7812892 81.82 µM -1.33180123646851 0.0973289716407192 no 3033 0.0914627557796499 4416 20205235 SGTC_1171 0368-0077 21.4 µM -1.33464267859384 0.0968607999760542 no 3034 0.090996661315102 4359 3239779 SGTC_1821 st053465 65.6 µM -1.3373508755446 0.096416123564757 no 3035 0.0905540657652069 4397 675086 SGTC_3103 9120822 49.47 µM -1.33968511108131 0.0960340555384118 no 3036 0.0901738700498542 4406 17141819 SGTC_42 0133-0086 60.653 µM -1.34031004654777 0.0959319551848811 no 3037 0.0900722832996912 4275 162923 Model of phenazepam hydroxylation. SGTC_1815 st051655 58.2 µM -1.34203767739972 0.0956501147280437 no 3038 0.0897918897358762 4337 5984156 SGTC_619 1652-1634 108 µM -1.34620091299077 0.0949734411118833 no 3039 0.0891188653613302 4383 5400454 SGTC_1713 st033146 12.748 µM -1.34796677303481 0.0946874937086609 no 3040 0.0888345348708814 4393 674619 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.34878208733046 0.0945556834127017 no 3041 0.0887034849448685 4355 676296 Flavone; oxidizing agent. SGTC_832 4083-0019 164 µM -1.35426227757421 0.0936732202429003 no 3042 0.0878263582098023 4491 1990758 SGTC_2225 6654152 15.4 µM -1.35599389854196 0.0933956492805744 no 3043 0.0875505546898022 4331 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1690 st023502 41.2 µM -1.35673952993812 0.0932763152746786 no 3044 0.0874319936981594 4412 24207482 SGTC_2673 kobusone 100 µM -1.35698204602521 0.0932375262631395 no 3045 0.0873934576578025 4500 6710676 An epoxy ketone and protein crosslinker. SGTC_1152 3909-8331 15.9 µM -1.35950233575858 0.0928351261755013 no 3046 0.0869937314176103 4376 16001939 SGTC_1567 st069303 68.4 µM -1.36306069331561 0.0922691723063126 no 3047 0.0864316916586013 4436 5581319 SGTC_2146 5545642 200 µM -1.36523949323666 0.0919238988022674 no 3048 0.0860888946679819 4373 825326 SGTC_1501 4491-0275 38.4 µM -1.3659424728151 0.0918127023468073 no 3049 0.0859785101420481 4410 5104718 SGTC_2205 7238770 200 µM -1.36831080603351 0.0914388155558116 no 3050 0.085607404879421 4468 279867 SGTC_2600 tangeritin 87.95 µM -1.37306136751545 0.0906922526861504 no 3051 0.0848666348572651 4319 68077 A bioactive flavone. SGTC_294 k038-0071 157 µM -1.37398607563911 0.090547459928109 no 3052 0.0847230026469545 4423 24152826 SGTC_104 0074-0074 590.992 µM -1.37575502500892 0.0902709523518254 no 3053 0.0844487449564397 4266 3943124 SGTC_3353 9151644 39.2805 µM -1.37698418195653 0.0900791902850747 no 3054 0.084258569198697 4431 4909158 SGTC_307 1501-1223 22.3 µM -1.37983295918871 0.0896359134302611 no 3055 0.0838190410257781 4446 2830329 SGTC_1326 1431-2094 10.8 µM -1.38161272877434 0.0893598012219383 no 3056 0.0835453217639929 4425 616278 SGTC_1206 3978-0017 132 µM -1.38473604315917 0.0888767826598964 no 3057 0.0830665968372641 4478 3873677 SGTC_2144 5628481 200 µM -1.38575160872489 0.0887201456360275 no 3058 0.0829113816868662 4407 2818399 SGTC_1991 st073000 8.92 µM -1.39648588698225 0.0870770832394708 no 3059 0.0812841137962086 4461 4301969 YIL048W NEO1 SGTC_2160 5660466 132.927 µM -1.39908371833391 0.0866828785264082 no 3060 0.0808939397787679 4366 2859134 SGTC_48 0382-0018 55 µM -1.40130896847176 0.0863462725198429 no 3061 0.0805608502281073 4473 762596 SGTC_2378 9074213 121.43 µM -1.40195007321171 0.0862494763977521 no 3062 0.080465078103201 4398 657714 SGTC_1033 k072-0102 21.3 µM -1.40223021737889 0.0862072047906387 no 3063 0.0804232554792636 4391 5965931 SGTC_1311 1190-0148 100 µM -1.4022439610522 0.0862051313745437 no 3064 0.0804212041138325 4473 1961333 SGTC_2908 7930301 100 µM -1.40342232825564 0.086027497664872 no 3065 0.0802454692962967 4397 2223178 SGTC_110 0850-0284 111.64 µM -1.40442568248234 0.0858764623948248 no 3066 0.0800960637951059 4346 3906265 SGTC_411 enrofloxacin 100 µM -1.40877745373635 0.0852236851531269 no 3067 0.0794504919669854 4476 71188 A bacterial gyrase inhibitor. SGTC_3019 9081971 49.47 µM -1.40935984326224 0.0851366080045383 no 3068 0.0793643958970571 4452 16451803 SGTC_2118 5526350 200 µM -1.41148566734752 0.084819326930024 no 3069 0.0790507294064087 4452 743594 SGTC_1720 st037298 9.481 µM -1.41432160617806 0.0843974419614985 no 3070 0.0786337479399918 4433 597396 SGTC_253 dyclonine 31.25 µM -1.4154919757618 0.0842237930742554 no 3071 0.0784621497272279 4532 3180 An oral anasthetic. SGTC_3287 9117173 37.0625 µM -1.41967715633674 0.0836050275058637 no 3072 0.0778508457563795 4462 2789709 SGTC_458 nppb 133 µM -1.42059620268047 0.0834696079795315 no 3073 0.0777170915335475 4486 4549 A chloride channel blocker. SGTC_2541 muurolladie-3-one 83.07 µM -1.42222873195866 0.0832294648536401 no 3074 0.0774799301922357 4398 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_213 1246-0773 967 nM -1.42238721387324 0.0832061800414272 no 3075 0.0774569364531274 4477 6251622 SGTC_1793 st048256 72.231 µM -1.42634929015261 0.0826256462844697 no 3076 0.0768837717239478 4412 672022 SGTC_835 0312-0010 67.2 µM -1.42898917746456 0.0822405388095312 no 3077 0.0765036720348468 4469 1626196 SGTC_1071 trifluoperazine 6.31 µM -1.43118683917274 0.0819209757561047 no 3078 0.0761883372020492 4497 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2273 7815444 169.05 µM -1.43243400078238 0.0817400420565911 no 3079 0.0760098268611948 4394 2824616 SGTC_2151 5563267 85.4165 µM -1.43758339648119 0.0809961749570082 no 3080 0.0752761473490833 4514 5310824 SGTC_3354 9151612 71.43 µM -1.43950974409665 0.0807192173509035 no 3081 0.0750030756003647 4453 27261949 SGTC_3013 9080133 71.4286 µM -1.44028461942914 0.0806080127775565 no 3082 0.0748934455299773 4513 17050193 SGTC_2853 9015042 58.44 µM -1.44143056321293 0.0804437672650247 no 3083 0.0747315404773971 4394 6457456 SGTC_108 0509-0257 621.132 µM -1.44217536674285 0.0803371519225481 no 3084 0.0746264539520021 4413 536624 SGTC_1683 st010134 710 nM -1.4464712677447 0.0797242956824047 no 3085 0.074022532603817 4431 3818134 SGTC_2077 5212015 200 µM -1.44674917850143 0.0796847708707995 no 3086 0.0739835926449083 4370 780900 SGTC_2193 5925765 200 µM -1.4539350944473 0.0786679208369437 no 3087 0.0729821509303458 4475 877370 SGTC_2798 7813637 45.45 µM -1.45626670263159 0.0783401062670749 no 3088 0.0726594532458099 4454 956368 SGTC_2218 6965428 192.983 µM -1.4577294237043 0.0781349830497229 no 3089 0.072457569176697 4386 675684 SGTC_1663 st014140 55.4 µM -1.45992519227959 0.0778278268409804 no 3090 0.0721553173453314 4547 4207120 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.46076123408294 0.0777111178988131 no 3091 0.0720404889309296 4421 1241132 A phosphatase inhibitor. SGTC_1738 st035555 74 µM -1.46079819780608 0.0777059609417784 no 3092 0.0720354152846127 4491 5331140 SGTC_730 1436-0052 41.2 µM -1.46227677574857 0.077499891576495 no 3093 0.0718326900145824 4509 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_163 TUB2.036 7.546 µM -1.46480796448067 0.0771480835595417 no 3094 0.0714866591541634 4411 15992207 YJR013W GPI14 SGTC_860 0443-0016 25.1 µM -1.46639805810135 0.0769276990642095 no 3095 0.0712699375350375 4499 5337942 SGTC_2555 cholic acid 100 µM -1.46845303151604 0.0766435922408666 no 3096 0.070990602753889 4434 6708657 Influences liver metabolism. SGTC_37 0566-0070 1.56 µM -1.46909111889588 0.0765555371215354 no 3097 0.0709040381487892 4402 1626686 SGTC_1060 3448-7350 82 µM -1.47055924016486 0.0763532307742431 no 3098 0.0707051768966983 4408 570178 SGTC_2125 5246583 200 µM -1.47175514314809 0.0761887368197548 no 3099 0.0705435053789643 4475 835267 SGTC_2241 6772625 37.8075 µM -1.47422177459498 0.0758503089154475 no 3100 0.0702109444875256 4284 2285411 SGTC_1804 st050076 49.1 µM -1.47859631786117 0.0752529281840923 no 3101 0.0696241187133025 4513 3895976 SGTC_251 melphalan 456.522 µM -1.48213224286283 0.0747726945984891 no 3102 0.0691525555291411 4522 460612 A DNA alkylator. SGTC_231 b-estradiol 524 µM -1.48271785354856 0.074693385770045 no 3103 0.0690746945683479 4480 450 A steroid. SGTC_809 3998-0021 90 µM -1.50000234200729 0.072381359642278 no 3104 0.066806897938238 4446 715485 SGTC_3246 9135460 32.98 µM -1.50029751253772 0.0723423584180361 no 3105 0.0667686767576432 4475 41446951 SGTC_2180 6301957 200 µM -1.5004476161836 0.0723225312268681 no 3106 0.0667492465571898 4519 845462 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.50048433607979 0.072317681529618 no 3107 0.0667444940080611 4491 115019 SGTC_5 0352-0601 109.883 µM -1.50200926990952 0.0721164993283778 no 3108 0.0665473574051401 4406 762456 SGTC_2875 9039966 71.43 µM -1.50779827784229 0.0713566684275777 no 3109 0.0658030815323251 4484 6463691 SGTC_2171 5739187 198.077 µM -1.51005942550586 0.0710615579900268 no 3110 0.065514130747696 4469 2262761 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.51060297986134 0.0709907567089356 no 3111 0.0654448171554473 4539 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1920 st075728 45.7 µM -1.51369906173195 0.0705885059077763 no 3112 0.0650510915222906 4480 3400306 SGTC_2073 5212005 126 µM -1.51510122045215 0.0704069112405041 no 3113 0.0648733863307182 4413 691789 SGTC_1621 st003705 32.4 µM -1.51696735887841 0.0701657835933663 no 3114 0.0646374626812348 4507 24207032 SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.52484037812998 0.0691554818792403 no 3115 0.0636494579582762 4548 5282309 SGTC_1334 1486-0610 236 µM -1.52520710424743 0.0691086965713327 no 3116 0.0636037245957891 4567 3742339 SGTC_2079 5212404 121 µM -1.5253177506534 0.0690945855793655 no 3117 0.0635899312220079 4457 758462 SGTC_1397 3532-0190 20.1 µM -1.53141845406592 0.0683199798449338 no 3118 0.0628330030473541 4491 5322280 SGTC_2348 9022543 33.42 µM -1.53218932369951 0.0682225813560415 no 3119 0.0627378611727002 4514 3162678 YDL140C RPO21 SGTC_2874 9043904 71.43 µM -1.53682805289111 0.067638744454786 no 3120 0.0621677109066365 4445 4463428 SGTC_1840 st055363 71 µM -1.53760289630847 0.0675415989528156 no 3121 0.0620728694367145 4534 676033 SGTC_70 0141-0289 43.283 µM -1.54419854629863 0.0667190330928413 no 3122 0.0612701204587096 4470 352408 SGTC_1658 st012944 20 µM -1.54593753515294 0.0665034545520879 no 3123 0.061059827180058 4367 24207260 SGTC_381 3461-2219 42.7 µM -1.54642489799468 0.0664431341178778 no 3124 0.0610009924572898 4499 2883159 SGTC_3117 9124945 49.47 µM -1.5492551792287 0.0660936698393276 no 3125 0.060660194806473 4435 17592065 SGTC_2147 5545932 89.7195 µM -1.55077746008712 0.0659062985377772 no 3126 0.0604775119982638 4565 797404 SGTC_332 4112-0506 40.9 µM -1.56366339993253 0.0643366712115609 no 3127 0.0589483186485583 4518 2790355 SGTC_2684 capsaicin 100 µM -1.56773009842776 0.0638473871222111 no 3128 0.0584720671464555 4554 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2942 9052777 62.25 µM -1.57005890407513 0.0635685033340136 no 3129 0.0582007040844531 4526 6469503 SGTC_1275 0867-0008 21.1 µM -1.57393874585165 0.0631059830672201 no 3130 0.0577508056350807 4515 3422836 SGTC_2582 agaric acid 100 µM -1.57427865861569 0.0630655868777089 no 3131 0.0577115206895928 4138 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_225 nsc-122657 1.016 µM -1.57573372279777 0.0628928905528426 no 3132 0.0575435911243371 4544 275685 SGTC_1851 st056236 18.9 µM -1.57583602598695 0.0628807624323092 no 3133 0.057531798747057 4505 5393171 SGTC_2879 9041815 71.43 µM -1.57751062160521 0.0626824967790528 no 3134 0.0573390400275899 4574 4942971 SGTC_2067 5224629 34.075 µM -1.57911324006956 0.0624932095300943 no 3135 0.0571550426580314 4505 2835000 SGTC_1994 st072947 40.9 µM -1.59530724962238 0.0606054315319724 no 3136 0.0553217726177221 4592 5286565 YDL195W SEC31 SGTC_2520 obtusaquinone 4.71 µM -1.59985576171939 0.0600833045547427 no 3137 0.0548152925762611 4570 5967872 SGTC_214 4373-3496 70 µM -1.60076896816626 0.0599789027254685 no 3138 0.0547140495666605 4604 3779166 SGTC_3240 9133527 49.47 µM -1.60372300078337 0.059642157427369 no 3139 0.0543875618117391 4532 17617455 SGTC_106 0092-0003 11.579 µM -1.60524502064076 0.0594692338490027 no 3140 0.0542199466356031 4477 1072148 SGTC_549 1661-1316 519 µM -1.60871272991999 0.0590767194576385 no 3141 0.053839585479675 4565 2857282 SGTC_3180 9109287 49.47 µM -1.61249989908961 0.0586503696901763 no 3142 0.0534266009361829 4576 18891271 SGTC_1770 st043884 66.3 µM -1.6146726681536 0.0584068575454635 no 3143 0.0531907997227047 4561 670149 SGTC_1140 3229-1848 2.98 µM -1.61668089811379 0.0581824928149063 no 3144 0.0529735896418206 4550 2849525 SGTC_2285 7945142 200 µM -1.61987357830814 0.0578271928305513 no 3145 0.0526297183024985 4559 2970608 SGTC_2607 solasodine 47.35 µM -1.62111694098357 0.0576892865786379 no 3146 0.0524962807026766 4508 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_934 2950-0684 338 µM -1.62642759443473 0.0571031702932595 no 3147 0.0519293623080763 4561 1121253 SGTC_1794 st048918 76.9 µM -1.62699646446564 0.0570406652676879 no 3148 0.0518689243430832 4527 672303 SGTC_2558 carylophyllene oxide 100 µM -1.62707712821196 0.0570318066394426 no 3149 0.0518603589816212 4643 6708694 An oxygenated terpenoid and antifungal agent. SGTC_295 k015-0027 31 µM -1.62826794260308 0.0569011553846786 no 3150 0.0517340418910703 4603 3887424 SGTC_1184 1269-1718 139 µM -1.62836703612707 0.0568902938822759 no 3151 0.0517235414565909 4607 5403821 SGTC_3020 9089140 49.47 µM -1.63096576876582 0.0566060328675061 no 3152 0.051448771342411 4581 17217859 SGTC_766 1391-0721 126 µM -1.6329087044496 0.0563942378916966 no 3153 0.0512440995868203 4575 1020919 YIL115C NUP159 SGTC_1077 5-fluorocytosine 377 nM -1.63487915624358 0.0561800818753844 no 3154 0.0510371913940757 4589 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2899 9053889 58.44 µM -1.6354305397718 0.0561202704328648 no 3155 0.0509794123341503 4567 6470052 SGTC_2545 solidagenone 89.61 µM -1.63623578663488 0.0560330113419041 no 3156 0.0508951246856594 4516 6708572 An anti ulcer agent SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.63940614416452 0.0556905009947044 no 3157 0.0505643514473578 4463 4330530 SGTC_2355 9061122 103.12 µM -1.64616138828665 0.0549662086450502 no 3158 0.049865268196787 4567 5302957 SGTC_2757 clomiphene 4.22 µM -1.64854719598817 0.0547121901378857 no 3159 0.0496202170879593 4565 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2990 9074105 71.4286 µM -1.65556549153613 0.0539703256731715 no 3160 0.0489049216891822 4509 6502001 SGTC_738 1315-0003 72.4 µM -1.65877453543532 0.053633779496456 no 3161 0.0485806167283303 4577 6251474 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.65919493938596 0.0535898133599239 no 3162 0.0485382585152161 4565 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_336 4111-0029 111 µM -1.66153826537418 0.0533452695902874 no 3163 0.0483026951831532 4591 3131175 SGTC_1080 nisoldipine 24.4 µM -1.67575508517246 0.0518805429908394 no 3164 0.0468930875561979 4601 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1069 diphenylcyclopropenone 8.49 µM -1.68072087174881 0.0513765260459044 no 3165 0.0464085722778207 4610 65057 A dermal irritant. YDR527W RBA50 SGTC_1560 lithocholic acid 53.1 µM -1.68090528451869 0.0513578838062789 no 3166 0.0463906566798706 4537 9903 A bile acid which acts as a detergent. SGTC_745 0469-0705 296 µM -1.6817234329062 0.0512752422753449 no 3167 0.0463112409661629 4609 3486736 SGTC_2081 5214970 32.255 µM -1.68412905843247 0.0510328617156768 no 3168 0.0460783648138246 4524 2063512 SGTC_1587 estradiol valerate 56.1 µM -1.68594446945834 0.0508505531028126 no 3169 0.0459032477908681 4633 13791 A steroid. SGTC_1040 k898-0338 155 µM -1.69550977198791 0.0498985270251693 no 3170 0.0449893790387297 4573 20969351 SGTC_488 nitrendipine 139 µM -1.69597970792676 0.049852123587004 no 3171 0.0449448615214873 4600 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1009 4106-0057 9.87 µM -1.69645399757433 0.0498053251524631 no 3172 0.0448999675336548 4576 2928005 SGTC_2604 4'-hydroxychalcone 11.32 µM -1.70537015141964 0.0489320678404931 no 3173 0.0440627057848201 4566 5282362 SGTC_98 0074-0023 107.663 µM -1.7062099844374 0.0488504481031888 no 3174 0.0439844952207616 4586 3563821 SGTC_1674 st016616 23.6 µM -1.70940548188242 0.0485408855877335 no 3175 0.0436879331014709 4558 625830 SGTC_1880 MG-132 525 µM -1.71061340078803 0.0484242782452946 no 3176 0.0435762517562606 4559 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_524 r073-0010 27.8 µM -1.72390845784513 0.0471555792912384 no 3177 0.0423621851122137 4549 2772106 SGTC_1383 3049-0032 20.7 µM -1.72423436521036 0.047124816988281 no 3178 0.0423327713241917 4631 712864 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.72997077043188 0.0465859884929858 no 3179 0.041817748833619 4545 6708739 YPR165W RHO1 SGTC_2524 avocatin b 10.57 µM -1.73159973705055 0.0464338820718921 no 3180 0.0416724265376494 4622 6710748 SGTC_310 1273-0058 1.06 µM -1.73816901591446 0.0458245102785409 no 3181 0.0410905184418034 4292 2734232 SGTC_3075 9116269 49.47 µM -1.74059480869396 0.0456011230218374 no 3182 0.0408773141304265 4593 17015205 YNL244C SUI1 SGTC_849 0386-0493 241 µM -1.74209725205857 0.0454632051103935 no 3183 0.0407457141815006 4623 726119 SGTC_2252 omeprazole 400 µM -1.74818262335823 0.0449080212485915 no 3184 0.0402162047672991 4638 4594 A proton pump inhibitor. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.74827820758174 0.0448993445913928 no 3185 0.0402079324518199 4577 5379071 SGTC_3 0833-0587 95.581 µM -1.75180317969587 0.0445803067662092 no 3186 0.0399038286415357 4514 5382644 SGTC_2769 toremifene 3.73 µM -1.75264677133963 0.0445042264948116 no 3187 0.039831328835327 4600 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2832 7992762 51.95 µM -1.75331447959974 0.0444440826585247 no 3188 0.0397740207161025 4526 2985177 SGTC_1057 3448-5381 134 µM -1.7611311190722 0.0437448584530615 no 3189 0.0391081065350409 4606 5497911 SGTC_2345 9052315 157.45 µM -1.76768089094729 0.0431658179867951 no 3190 0.0385571331701015 4600 6469265 SGTC_423 5-fluorouracil 457 µM -1.77167320892813 0.042815919625961 no 3191 0.0382244096947174 4539 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1472 k841-0093 193 µM -1.77415127022945 0.042599890592028 no 3192 0.0380190660460426 4658 X1472 SGTC_1449 4112-4002 201 µM -1.77640753840503 0.0424039640708977 no 3193 0.0378328847480837 4642 2059539 SGTC_313 3474-0040 5.03 µM -1.77969643042807 0.0421196743212717 no 3194 0.037562827483583 4629 1043375 YIL048W NEO1 SGTC_2653 dihydrofissinolide 100 µM -1.78728344109394 0.0414697396909205 no 3195 0.0369458444883922 4700 6857746 SGTC_97 0535-0701 19.132 µM -1.79439766693376 0.0408677115836494 no 3196 0.0363748595257938 4542 2832013 YGL099W LSG1 SGTC_1113 artemisinin 1.17947 µM -1.800238064268 0.0403787955896343 no 3197 0.0359115279279055 4648 2240 An anti-malaria and mitochondrial poison. SGTC_546 peri-Naphthalide 147 µM -1.80852974955698 0.0396928445444362 no 3198 0.0352620454834756 4597 223824 A penicillin ester. SGTC_1555 citronellol 128 µM -1.81322992845909 0.0393082370974484 no 3199 0.0348981828119458 4618 8842 A terpine precursor. SGTC_1387 3342-1166 1.8 µM -1.81892520157166 0.0388462721450985 no 3200 0.0344614211968932 4644 3418228 SGTC_566 0958-0068 16.5 µM -1.82908271065872 0.0380333396067792 no 3201 0.0336936093002809 4546 6815365 SGTC_3204 9114183 49.47 µM -1.83057703331915 0.0379149244678093 no 3202 0.0335818495681324 4577 17027248 SGTC_3223 9129970 49.47 µM -1.844130725125 0.0368545664800264 no 3203 0.0325820455673758 4639 17248386 SGTC_2456 5770359 74.46 µM -1.84666228427167 0.036659225758388 no 3204 0.0323980505579091 4601 3118787 SGTC_1607 st000305 50.6 µM -1.84923483217361 0.0364615906771857 no 3205 0.0322119555601267 4640 5457690 SGTC_319 1348-1596 45.5 µM -1.85724672401833 0.035851659506058 no 3206 0.0316380301244864 4692 5380505 SGTC_2006 4011487 200 µM -1.85781616141849 0.0358086293371331 no 3207 0.031597562638939 4585 45595294 SGTC_2958 9077254 16.72 µM -1.85886630124627 0.0357293853401346 no 3208 0.0315230458751708 4645 16457351 SGTC_2022 5136654 200 µM -1.85950314860508 0.035681398611851 no 3209 0.0314779266881271 4619 1713771 SGTC_1498 4478-3555 97.6 µM -1.86065594301168 0.0355946693998068 no 3210 0.0313963896121071 4660 3437919 SGTC_3292 9120825 59.784 µM -1.86082346375729 0.0355820805543004 no 3211 0.03138455542511 4623 24824900 SGTC_1955 wogonin 32.4 µM -1.86301062696606 0.0354180543118394 no 3212 0.0312303855528303 4616 5281703 A flavanone. SGTC_2675 theaflavin digallate 100 µM -1.86315965200438 0.0354069007835571 no 3213 0.0312199038339068 4600 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_3156 9099931 49.47 µM -1.86365947116552 0.0353695136876706 no 3214 0.0311847701526373 4673 18111053 SGTC_1529 apigenin 74 µM -1.86956200000847 0.0349304411034482 no 3215 0.0307723331763018 4642 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2696 st077691 74.316 µM -1.87154534506566 0.0347839136988712 no 3216 0.0306347654327023 4636 757133 SGTC_60 0986-0278 202 µM -1.87700757622897 0.0343829771212561 no 3217 0.0302585277462377 4603 3110598 SGTC_188 3229-0966 278.469 µM -1.88069715054116 0.0341143113250004 no 3218 0.0300065637593797 4685 5722370 SGTC_1647 st011722 22.4 µM -1.88141645196115 0.0340621351282501 no 3219 0.0299576453073341 4651 2854783 SGTC_2141 5621638 7.665 µM -1.88453067437124 0.0338369942980285 no 3220 0.0297466148336365 4663 2856238 SGTC_2087 5276107 200 µM -1.88995516536419 0.0334477579921067 no 3221 0.0293819783084348 4655 144405 SGTC_2772 vinpocetine 57.06 µM -1.89829310303119 0.0328566602541662 no 3222 0.0288287410062404 4640 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2080 5212524 12.4 µM -1.90440190771458 0.0324290789841125 no 3223 0.0284289304741465 4621 260183 SGTC_2745 rifampicin 24.3 µM -1.90811510965956 0.0321714268736437 no 3224 0.0281881701169582 4748 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_3101 9120531 49.47 µM -1.91126111624104 0.0319544558869842 no 3225 0.0279855166644744 4618 24824904 SGTC_2833 9001315 45.46 µM -1.91883893573057 0.0314367932975873 no 3226 0.0275023603088669 4594 2989378 SGTC_2288 7946289 167.31 µM -1.9270295891387 0.0308850831453854 no 3227 0.0269879712651332 4650 1246052 SGTC_326 k292-0812 17.5 µM -1.93204327375897 0.0305513404842917 no 3228 0.0266770824701972 4673 3579357 SGTC_2921 7974240 10.71 µM -1.93490224695458 0.0303623701496498 no 3229 0.0265011462122469 4687 2979074 YDR527W RBA50 SGTC_2543 pimpinellin 60.67 µM -1.93637880146826 0.03026515382119 no 3230 0.0264106619246234 4555 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1824 st053723 68.6 µM -1.93702520165286 0.0302226761047082 no 3231 0.0263711314064313 4673 675225 SGTC_2310 7668677 200 µM -1.94101194827096 0.0299617809026278 no 3232 0.0261284140629386 4619 2197143 SGTC_2820 7989630 71.43 µM -1.95211420342906 0.0292450695809095 no 3233 0.0254623236470082 4694 2984098 SGTC_2785 7756463 72.73 µM -1.95446468248238 0.0290951742427783 no 3234 0.0253231438320724 4647 2201551 SGTC_920 mycophenolic acid 780.421 nM -1.96623736381037 0.0283539780006335 no 3235 0.0246355991620399 4659 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1210 3013-0140 750 nM -1.96725525150877 0.0282906375313016 no 3236 0.0245768955683432 4696 905973 SGTC_2953 9074162 66.49 µM -1.97649663816012 0.0277209411151742 no 3237 0.0240492780640028 4661 16451992 SGTC_567 1080-0542 68.4 µM -1.97664559985762 0.0277118370650827 no 3238 0.0240408519643999 4597 5950415 SGTC_483 fpl-64176 144 µM -1.9816792831323 0.0274056564368801 no 3239 0.0237575736611654 4752 3423 SGTC_620 0109-0052 432 µM -1.99174687466158 0.0268017413288249 no 3240 0.0231994189032585 4709 493037 SGTC_586 0957-0265 8.15 µM -1.99835088870616 0.026411659515612 no 3241 0.022839316014034 4607 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_209 4077-0173 175.592 µM -1.99887124666911 0.0263811260346308 no 3242 0.0228111432593303 4665 15993494 SGTC_1243 0416-0003 5.65 µM -2.00618880117011 0.0259548632258428 no 3243 0.0224180541211303 4665 2141977 SGTC_1458 k015-0034 6.33 µM -2.02488089289456 0.0248921009353743 no 3244 0.0214397980187977 4709 3598957 SGTC_3300 9124615 50.48 µM -2.02858154465258 0.0246860824837968 no 3245 0.0212504649453482 4671 24824903 SGTC_334 1502-1024 68.5 µM -2.03518975727034 0.0243217555849778 no 3246 0.0209158916413812 4689 3296216 SGTC_129 0088-0017 176.636 µM -2.03593395351255 0.0242810105317934 no 3247 0.0208784939014767 4573 182446 SGTC_1565 sinapyl alcohol 95.1 µM -2.04006661296284 0.0240557873034445 no 3248 0.0206718457600656 4684 5280507 A phenol propionate derived from cinnamic acid. SGTC_699 0375-0592 111 µM -2.04977169342447 0.0235337693255938 no 3249 0.0201933575515001 4744 762578 SGTC_612 0302-0167 22.4 µM -2.05737897607211 0.0231312797095194 no 3250 0.0198248929274771 4686 235821 SGTC_1010 4112-3296 15.2 µM -2.05900309242962 0.0230461051884818 no 3251 0.0197469711225746 4713 704384 SGTC_889 0919-1524 82.7 µM -2.06838665940879 0.0225591523841428 no 3252 0.0193018393319735 4715 3905452 SGTC_1625 st003711 30.1 µM -2.08461769494548 0.0217373364407504 no 3253 0.0185520084904159 4690 24207034 YER133W GLC7 SGTC_1879 gemcitabine 100 µM -2.09375570390125 0.0212858868521791 no 3254 0.0181408739774222 4682 60750 A nucleoside analog which inhibits DNA replication. SGTC_1640 st009078 66.4 µM -2.10207144955047 0.0208819758128841 no 3255 0.0177735087064309 4708 690618 SGTC_396 dithiazanine 1.25 µM -2.11307424856784 0.0203575369673105 no 3256 0.0172972066874581 4690 10578 An antihelmenthic. SGTC_2700 st077718 96.8 µM -2.11499931025183 0.0202669376683776 no 3257 0.0172150030510226 4680 904970 SGTC_1208 2323-2347 50.3 µM -2.11950008240397 0.0200564505807109 no 3258 0.017024113399863 4709 5412760 SGTC_2109 5483026 200 µM -2.12995240039901 0.0195747716173535 no 3259 0.0165877716723923 4720 759335 SGTC_3260 9137109 49.47 µM -2.13214859961407 0.0194748218811878 no 3260 0.0164973162121561 4718 17478346 SGTC_1896 st058441 89 µM -2.13325817625879 0.0194244897460331 no 3261 0.0164517765519682 4718 688759 SGTC_1995 st072814 61.1 µM -2.14659256345898 0.0188282152504932 no 3262 0.0159128662341635 4724 5769371 SGTC_330 1488-0319 80.1 µM -2.14781690256086 0.0187742554783723 no 3263 0.0158641518631962 4737 6846614 SGTC_2275 7947463 200 µM -2.15363949273436 0.0185194365114442 no 3264 0.0156342273188568 4681 1225414 SGTC_1540 guanosine 70.6 µM -2.15688642161576 0.0183786217105487 no 3265 0.0155072575865542 4699 6802 Guanosine is a purine nucleoside SGTC_2119 5528445 120.635 µM -2.16058974643575 0.0182191279851612 no 3266 0.0153635220878837 4727 791935 SGTC_1746 st038117 42 µM -2.17075055694221 0.0177875703542855 no 3267 0.0149750166254928 4707 2898218 SGTC_80 0159-0065 512.242 µM -2.18741047157636 0.0170988518152199 no 3268 0.0143562862093811 4705 1548079 SGTC_1180 1193-0155 285 µM -2.19623259470899 0.0167434668009767 no 3269 0.0140376497508606 4748 2921347 SGTC_2940 9060638 45.86 µM -2.19920938921479 0.0166249859123351 no 3270 0.013931518511761 4684 4027022 SGTC_1570 verbenone 133 µM -2.19999792091925 0.0165937216232792 no 3271 0.0139035212682102 4715 29025 A natural terpanoid with antifungal properties. SGTC_2927 9011802 47.9 µM -2.20737804901584 0.0163035402150065 no 3272 0.0136438293170437 4679 43912568 SGTC_41 0478-0632 82.643 µM -2.21421812560649 0.0160384848999478 no 3273 0.0134068887916198 4693 3750424 SGTC_2360 9040895 200 µM -2.21993512972425 0.0158197908224545 no 3274 0.0132115857124683 4726 4914414 SGTC_2692 st077426 47.7 µM -2.22647626500598 0.0155727126780299 no 3275 0.0129911485384815 4709 25238571 SGTC_369 0957-0393 4.5 µM -2.22871541095182 0.0154888977884278 no 3276 0.0129164231068965 4711 6997992 SGTC_2264 7948757 110.76 µM -2.25192074269308 0.0146428444085286 no 3277 0.0121636405310393 4697 2971411 SGTC_2691 st077356 60.2 µM -2.25786613789034 0.0144325881104012 no 3278 0.0119770031581992 4703 2839272 SGTC_357 1325-0123 420 µM -2.27740593928514 0.01375977975974 no 3279 0.0113809978818191 4731 1098503 SGTC_296 1222-0039 74.9 µM -2.28048199499706 0.0136563664388239 no 3280 0.0112895587285281 4752 5984176 SGTC_358 0075-0058 9.45 µM -2.2840036864922 0.0135387954191755 no 3281 0.0111856571447631 4689 1069125 SGTC_306 1672-3436 11.6 µM -2.29250912622567 0.013258440203925 no 3282 0.0109381407673153 4748 6797378 SGTC_931 2812-0076 566 µM -2.31937288753584 0.0124056481690843 no 3283 0.0101874132131112 4707 3450959 SGTC_212 3807-4682 38.772 µM -2.34844589288833 0.01153665188791 no 3284 0.00942596898836409 4767 3125501 YBL034C STU1 SGTC_2483 5729050 27.16 µM -2.35147024153363 0.0114493644734762 no 3285 0.00934969265168799 4722 2865180 SGTC_3290 9121031 71.43 µM -2.353964995132 0.0113777943714069 no 3286 0.00928718007320383 4737 17014854 SGTC_1098 clofazimine 15.1 µM -2.35819532553262 0.0112573218938161 no 3287 0.00918201372372358 4762 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_973 1325-0077 65.9 µM -2.35911012284792 0.0112314163518055 no 3288 0.00915940936352859 4757 2835149 SGTC_2015 5119600 184 µM -2.37425331301983 0.0108100548826101 no 3289 0.0087922410111493 4711 2828786 SGTC_1660 st012960 28.1 µM -2.38362171429053 0.0105563251405665 no 3290 0.00857160719268125 4768 24207266 SGTC_2906 7926292 26.41 µM -2.38591451638241 0.0104950239355601 no 3291 0.00851835531950792 4736 2966319 SGTC_1766 st045414 44.774 µM -2.40659425165273 0.00995599599322612 no 3292 0.00805102424212499 4746 253960 SGTC_1870 st057514 26.5 µM -2.42486037783602 0.00950014391484459 no 3293 0.0076571376394152 4753 5393161 SGTC_1480 1070-0044 41.2 µM -2.43099199310076 0.00935126806675159 no 3294 0.00752877365593412 4780 3124987 SGTC_2687 chenodiol 100 µM -2.43346405396324 0.00929182607712047 no 3295 0.00747756013498232 4751 5702181 A cholesterol synthesis inhibitor. SGTC_168 3970-0862 530.542 µM -2.43353115598453 0.00929021719361164 no 3296 0.00747617427574102 4709 3135186 SGTC_1348 1493-0373 93.8 µM -2.50305796022498 0.00774868350541106 no 3297 0.00615626892856726 4766 3010129 SGTC_2057 5236571 38.335 µM -2.52512882908634 0.0073088258304878 no 3298 0.00578279413228306 4726 54684039 YBR257W POP4 SGTC_1204 4049-0315 18.3 µM -2.52618371658131 0.00728836512656591 no 3299 0.00576545820079324 4733 588402 SGTC_109 0132-0036 33.701 µM -2.52748454189409 0.00726320373239734 no 3300 0.00574414406113645 4743 67274 A color developer. SGTC_537 1334-0398 209 µM -2.53353659359924 0.00714714548057269 no 3301 0.00564589747879216 4771 5846986 SGTC_2547 epiafzelechin trimethyl ether 100 µM -2.54068920300884 0.00701209388873829 no 3302 0.0055317107992909 4765 6708630 An antioxidant. SGTC_3218 9131285 49.47 µM -2.55175843242946 0.00680752955419821 no 3303 0.00535904015169799 4729 17156417 SGTC_585 0kpi-0023 191 µM -2.55529259217581 0.00674333632215279 no 3304 0.00530492853315015 4737 64601 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -2.55588538203056 0.0067326216382006 no 3305 0.00529590005363281 4760 23847180 SGTC_2539 epi(13)torulosol 80 µM -2.55954234217415 0.0066668541064252 no 3306 0.00524050435359492 4731 6708597 SGTC_354 2783-3500 4.88 µM -2.5644651314529 0.00657921864457557 no 3307 0.00516674807784192 4758 6740761 SGTC_970 1315-0089 19.5 µM -2.57871548573869 0.00633124945746465 no 3308 0.00495842135087875 4769 6811083 YLR033W RSC58 SGTC_3173 9105693 49.47 µM -2.58735752218738 0.0061849326405707 no 3309 0.00483575919683819 4757 17096658 SGTC_3116 9124943 49.47 µM -2.59968976666943 0.00598132506335359 no 3310 0.0046654036133683 4767 41905195 YPL160W CDC60 SGTC_527 4476-4215 268 µM -2.6198521953455 0.00566122014012789 no 3311 0.00439839423336105 4766 4418754 SGTC_2640 pentamidine 10.38 µM -2.64669732428445 0.00525866198800965 no 3312 0.0040641034154007 4746 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2912 7964298 10.93 µM -2.65739894758714 0.00510542002788773 no 3313 0.00393730972016672 4760 2975850 SGTC_169 k015-0017 16.025 µM -2.67516077669516 0.00485983920275212 no 3314 0.00373467101453243 4727 1840002 SGTC_827 3253-0474 693 µM -2.68013115612565 0.00479302953905523 no 3315 0.00367966594703286 4780 5402065 SGTC_1247 0448-0043 5.84 µM -2.71397130132584 0.00435952758629545 no 3316 0.0033240962667467 4748 3089013 YGL099W LSG1 SGTC_1502 4534-4282 27.7 µM -2.7195620223869 0.0042913831504581 no 3317 0.00326842173635163 4787 3278949 SGTC_496 calpeptin 138 µM -2.72516577469447 0.00422403704068967 no 3318 0.00321346045485128 4773 73364 A calpain inhibitor. SGTC_1506 4226-2149 212 µM -2.73063826053482 0.004159182335637 no 3319 0.003160590615178 4772 991114 SGTC_1211 1056-0033 32.3 µM -2.74747711790562 0.00396517539945528 no 3320 0.00300278496586851 4784 6741922 SGTC_2678 equilin 100 µM -2.74961107770601 0.00394117693906097 no 3321 0.00298330181613716 4783 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1124 fisetin 1.16336 µM -2.75546241173978 0.00387603905751502 no 3322 0.00293046191876995 4772 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2271 7849410 118.62 µM -2.76791509921108 0.00374061516378499 no 3323 0.00282080751536192 4748 972430 SGTC_3028 9087778 49.47 µM -2.77465584486152 0.00366909301638031 no 3324 0.00276300753948948 4765 17217395 SGTC_1853 st056710 91.2 µM -2.77542461972436 0.0036610144324496 no 3325 0.00275648387897575 4789 269167 SGTC_3106 9121286 49.47 µM -2.83135358276223 0.00311441226187617 no 3326 0.00231757248925424 4766 15943471 SGTC_2324 6149169 200 µM -2.91000182807497 0.00246988456304684 no 3327 0.00180713321072432 4787 2888231 SGTC_289 k017-0060 526 µM -2.9121375063042 0.00245420243705145 no 3328 0.00179482287600544 4788 5512909 SGTC_552 k242-0005 476 µM -2.95248365847193 0.00217437771354562 no 3329 0.00157614377362269 4797 4088318 SGTC_1385 3091-4834 14.1 µM -2.96423448136581 0.00209850169518288 no 3330 0.00151718488351437 4779 4072814 SGTC_464 bw-b 70c 158 µM -2.97287169514385 0.00204427087546333 no 3331 0.00147513875297092 4788 5353454 SGTC_589 1227-0070 34.1 µM -3.03773259248655 0.00167597336162295 no 3332 0.00119182686266048 4798 2841384 SGTC_1795 st049545 62.3 µM -3.053988231828 0.00159368065732542 no 3333 0.00112910469493877 4794 5291882 SGTC_517 1365-0151 113 µM -3.07205242585895 0.00150656478679328 no 3334 0.00106296191821219 4776 768657 SGTC_351 caspofungin 25 nM -3.0821761426979 0.00145966374365253 no 3335 0.00102746600306683 4790 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_155 k072-0202 43.6 µM -3.1528740771821 0.00116754806661318 no 3336 0.000808357653312094 4791 5857737 SGTC_348 k064-0012 10.7 µM -3.17657126034981 0.00108231302847374 no 3337 0.000745135859622857 4795 5066323 SGTC_2708 st078559 56 µM -3.20317503235179 0.000993445022906161 yes 3338 0.000679606717209058 4800 17250902 SGTC_2350 9023895 38.85 µM -3.28147789144309 0.000769299180285737 yes 3339 0.000516323097927333 4776 2997209 SGTC_3076 9116187 49.47 µM -3.28867873044556 0.00075122181806007 yes 3340 0.000503294253605606 4796 27241210 SGTC_936 3005-4620 401 µM -3.44482220275369 0.000443674539328731 yes 3341 0.000285717566610968 4795 777207 SGTC_1464 k208-0027 110 µM -3.52338430354174 0.000337705245171098 yes 3342 0.000213036535900103 4785 X1464 SGTC_94 0334-0113 514.748 µM -3.54161820157445 0.000316735472481224 yes 3343 0.000198840317868787 4803 6795178 SGTC_975 1335-0046 28.5 µM -3.59744548564511 0.000259822600807415 yes 3344 0.000160678910179976 4803 16486740 SGTC_469 w7 172 µM -3.67147981707057 0.000198972249595647 yes 3345 0.000120575062365923 4808 45115570 A P450 inhibitor. SGTC_604 1000-0114 314 µM -3.73129947378297 0.000159826064094279 yes 3346 9.52473044215832e-05 4807 1572745 SGTC_3027 9089541 49.47 µM -3.95913127818578 6.74339292111465e-05 yes 3347 3.76114411524809e-05 4801 9943819 SGTC_1646 st011709 75.6 µM -3.96229444256868 6.66095907230851e-05 yes 3348 3.71164559440191e-05 4806 5757843 SGTC_1928 4'-methoxychalcone 40.3 µM -4.32715994379567 1.51995353901025e-05 yes 3349 7.55221411241374e-06 4809 641818 SGTC_282 k297-0036 65.7 µM -4.36854817286558 1.27594413637023e-05 yes 3350 6.25376151671875e-06 4798 5061378 SGTC_606 k015-0008 38.6 µM -4.3953213658117 1.13846781475351e-05 yes 3351 5.53044961775902e-06 4809 1970475 SGTC_355 1311-2252 105 µM -6.00779638134444 3.67470401228916e-09 yes 3352 9.40309074390049e-10 4808 5338538