SGTCid condition conc unit MMT1|YMR177W.score MMT1|YMR177W.strain.pval MMT1|YMR177W.strain.significant MMT1|YMR177W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_367 0335-0881 7.1 µM 5.36172991004902 6.47133298451335e-08 yes 1 4.12143618996926e-08 32 23828853
SGTC_1170 0310-0127 64.8 µM 5.17748571523985 1.71182613264837e-07 yes 2 1.12448078821735e-07 6 774975
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 4.17094929757804 1.98860132814204e-05 yes 3 1.51666677068109e-05 30 4174840
SGTC_1161 k007-0610 110 µM 4.00399398085601 3.99602623058189e-05 yes 4 3.11409749189718e-05 118 5843850
SGTC_640 3381-0960 37.1 µM 3.96427852832122 4.6998395089371e-05 yes 5 3.68091288035712e-05 12 1745025
SGTC_1178 0988-0033 191 µM 3.7593549956297 0.000106074335820586 yes 6 8.51759885787257e-05 32 5392207
SGTC_146 3448-8650 53.125 µM 3.70537391718064 0.000130603062780137 yes 7 0.000105539555001717 157 2891488 YIL048W NEO1
SGTC_768 0384-0033 77.3 µM 3.54515826695411 0.000238384341144251 yes 8 0.000196188705526078 102 3965305 YMR134W ERG29
SGTC_521 r062-0005 13.8 µM 3.3979505844554 0.000405906325878867 yes 9 0.000339463411752065 26 2832033
SGTC_457 grayanotoxin iii 135 µM 3.36010683502476 0.000463944848859006 yes 10 0.000389561687900406 110 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1319 1306-0155 43.7 µM 3.34535259872944 0.000488586932447547 yes 11 0.000410890132328782 57 3122360
SGTC_1208 2323-2347 50.3 µM 3.3070224188011 0.000558380887671989 yes 12 0.000471466726321854 24 5412760
SGTC_3036 9090181 49.47 µM 3.23083986662171 0.000725219677310996 yes 13 0.000617135340820075 16 25236586
SGTC_365 0121-0052 13.6 µM 3.21564541141608 0.000763557986935583 yes 14 0.000650757692753538 111 3101739
SGTC_1111 tnp00062 510.699 nM 3.18857098860732 0.00083653118814165 yes 15 0.000714889493836164 25 676306
SGTC_1842 st055362 61.2 µM 3.12358797894127 0.00103861023826581 no 16 0.000893302218834693 44 676032
SGTC_1013 4112-3890 241 µM 3.09592479418166 0.00113750709360823 no 17 0.000981000583512418 78 705171
SGTC_962 1254-0300 21.5 µM 3.02282965723188 0.00144175376837829 no 18 0.00125211581098443 58 7340576
SGTC_1992 st073643 23.3 µM 2.88713812851485 0.00221034368382126 no 19 0.00194381759113753 48 3161292
SGTC_103 0844-0104 51.839 µM 2.83059297494036 0.00262831982621492 no 20 0.00232309026405023 228 5375804
SGTC_624 k048-0052 28 µM 2.79950734572587 0.00288736536064201 no 21 0.0025590326021646 73 6835531
SGTC_3023 9089636 49.47 µM 2.79288447662902 0.00294544538467778 no 22 0.00261201724401358 37 17249241
SGTC_1904 st060225 78 µM 2.76976820311649 0.00315650950102365 no 23 0.00280480993193657 69 66595
SGTC_1570 verbenone 133 µM 2.74728048481302 0.00337479843594356 no 24 0.0030045859907047 79 29025 A natural terpanoid with antifungal properties.
SGTC_1147 3809-1045 12.3 µM 2.7471246940524 0.00337635689337796 no 25 0.00300601361862303 104 325925
SGTC_2947 9072639 7.68 µM 2.73106130010446 0.00354056177250616 no 26 0.00315653640061232 135 16488146
SGTC_2930 9013230 14.89 µM 2.71045712714989 0.00376166568790539 no 27 0.00335952671601478 131 2995857
SGTC_3035 9091303 49.47 µM 2.70369071653646 0.00383693152053808 no 28 0.00342870416758141 43 25237002
SGTC_698 k064-0052 127 µM 2.69056872788396 0.00398675068056142 no 29 0.00356651703586441 28 5088751
SGTC_3022 9087993 49.47 µM 2.68819296551264 0.00401442908834914 no 30 0.00359199342040726 47 17173644
SGTC_78 0336-0123 156.75 µM 2.66372988439974 0.00430959799469382 no 31 0.00386397944076856 79 6765896
SGTC_2556 citropten 84.59 µM 2.64843075729225 0.00450391363312959 no 32 0.0040433206581849 127 2775 A potential DNA crosslinker.
SGTC_307 1501-1223 22.3 µM 2.63600990605164 0.00466738670305134 no 33 0.00419436412665007 72 2830329
SGTC_2850 9015429 58.44 µM 2.63063820744275 0.00473970961503641 no 34 0.00426123545227317 91 6457570
SGTC_843 0310-0051 143 µM 2.60765817956217 0.00506051558564228 no 35 0.00455819696191294 92 2065037
SGTC_533 1222-0222 6.71 µM 2.59317479040754 0.00527250663267188 no 36 0.00475472135817363 106 3982874
SGTC_1714 st033236 13.627 µM 2.58584432501607 0.00538278317597962 no 37 0.00485703966925232 110 2916566
SGTC_308 4092-1169 104 µM 2.57821379197139 0.00549974738790711 no 38 0.00496562661212191 147 2268590 YDL196W YDL196W
SGTC_703 3875-0075 71.8 µM 2.5771528393277 0.0055161877087189 no 39 0.00498089460391862 55 2850814
SGTC_931 2812-0076 566 µM 2.56705928875186 0.00567479235015906 no 40 0.00512825370096436 119 3450959
SGTC_452 diindolylmethane 8 µM 2.56476622259203 0.00571138384422138 no 41 0.00516226707123978 69 3071 Inhibits expression of several cancer promoting factors.
SGTC_162 k030-0015 37.8 µM 2.55465469133495 0.00587524801505204 no 42 0.00531465936372577 84 1809920 YMR134W ERG29
SGTC_1236 0330-0013 258 µM 2.55081609050559 0.00593853887299847 no 43 0.00537355099974086 91 4617066
SGTC_644 1498-1197 63.3 µM 2.5395337637032 0.0061280756438813 no 44 0.00555001653610785 120 6741615
SGTC_1721 st082152 9.2685 µM 2.52571680387371 0.0063674801693337 no 45 0.00577312570737699 105 5296051
SGTC_1510 1123-0200 71.5 µM 2.52127776791285 0.00644613254858122 no 46 0.00584647545795457 165 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_449 xestospongin c 11.1929 µM 2.51137974304615 0.00662461148620061 no 47 0.00601301262950589 172 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1504 k297-0033 30 µM 2.50948996293826 0.00665917997506802 no 48 0.00604528257885563 91 4388117
SGTC_830 4076-0286 57.8 µM 2.50477591283625 0.00674610683189669 no 49 0.00612644978404739 235 6866659
SGTC_2023 5144124 124 µM 2.49868045174238 0.00685999241764953 no 50 0.00623283294992118 102 2830192
SGTC_771 0250-0039 27.3 µM 2.4919891388485 0.00698696275838495 no 51 0.00635149609059207 89 3005115
SGTC_1526 st051518 75 µM 2.46350831035393 0.00755089688838283 no 52 0.00687923529708711 108 673993
SGTC_1124 fisetin 1.16336 µM 2.4571716179567 0.00768168728814462 no 53 0.007001788562971 146 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_538 2922-0838 53.3 µM 2.44209966784683 0.0080008171853473 no 54 0.00730105734121433 158 777039
SGTC_693 4161-2696 114 µM 2.43345036493343 0.00818917112252775 no 55 0.00747784288255183 71 805759
SGTC_2656 pseudo-anisatin 100 µM 2.42864536400455 0.00829548279530946 no 56 0.00757767419092316 44 6708809 A neurotoxin.
SGTC_1447 4239-0816 81.9 µM 2.42385346706803 0.00840270970394487 no 57 0.00767840026164223 141 1341554
SGTC_2979 9012552 45.46 µM 2.4109869218782 0.00869666213713534 no 58 0.0079547094554296 63 17100905
SGTC_2446 5162541 200 µM 2.40399006757451 0.0088602688185467 no 59 0.00810860695067639 93 1549321
SGTC_1990 st072050 59.8 µM 2.39143273298582 0.00916066852180874 no 60 0.00839137950864129 108 17233948
SGTC_37 0566-0070 1.56 µM 2.38528831752718 0.00931087862693338 no 61 0.00853287031756931 155 1626686
SGTC_1555 citronellol 128 µM 2.38370381907476 0.00934996203791625 no 62 0.00856969522356223 65 8842 A terpine precursor.
SGTC_1092 toremifene 6.32 µM 2.38129410689084 0.00940967536518953 no 63 0.00862596595530487 148 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1131 3454-3128 32.3 µM 2.37831335283914 0.00948400054703061 no 64 0.00869601964066783 187 710982
SGTC_1473 k844-0725 134 µM 2.37269521744498 0.00962548546042706 no 65 0.00882941433713707 129 54682906
SGTC_3220 9131269 49.47 µM 2.34768400634839 0.0102779766345367 no 66 0.00944526994611419 86 17722206
SGTC_2984 9022109 38.96 µM 2.34711701132118 0.0102932049628484 no 67 0.00945965611838263 83 6459207
SGTC_3229 9132204 49.47 µM 2.33607467752387 0.010593726920507 no 68 0.00974367490494997 72 17682924
SGTC_2677 mitomycin C 100 µM 2.32766020665077 0.0108278342473652 no 69 0.0099650768709655 101 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3316 9136639 10.545 µM 2.30368674916129 0.0115196802435643 no 70 0.0106201171034047 124 4903665
SGTC_2987 9018338 71.43 µM 2.28638180523147 0.0120426466382092 no 71 0.0111159659118105 166 5055682
SGTC_755 1995-0008 37.3 µM 2.28197452678133 0.0121790816880382 no 72 0.0112454221091662 137 689533
SGTC_709 3807-1509 243 µM 2.28076196355854 0.0122168529105774 no 73 0.0112812681438831 109 1886677 YPL242C IQG1
SGTC_684 1140-0066 328 µM 2.27834685138158 0.0122923859536122 no 74 0.0113529601573658 195 6813534
SGTC_1292 0kpi-0043 232 µM 2.27444562098398 0.0124152523086347 no 75 0.0114696035641674 139 3333905
SGTC_2421 5690543 90.72 µM 2.26807330109716 0.0126182316186201 no 76 0.0116623696772913 155 3397993
SGTC_149 3970-0822 46.1 µM 2.25433292211224 0.0130657028656245 no 77 0.0120876158426459 305 3114250 YBL034C STU1
SGTC_1945 st075991 56.6 µM 2.24955167766377 0.0132245943420696 no 78 0.0122387094287194 145 1084980
SGTC_2355 9061122 103.12 µM 2.24826094344932 0.0132677734502827 no 79 0.0122797778072091 121 5302957
SGTC_3099 9120367 49.47 µM 2.24678210500463 0.0133173948888405 no 80 0.0123269779802629 140 24824940
SGTC_514 4466-0038 2.65 nM 2.24143504978119 0.0134981516542085 no 81 0.0124989541439722 335 5722064
SGTC_3241 9133421 49.47 µM 2.22895205166619 0.0139284008531093 no 82 0.0129085476232921 56 17018221
SGTC_169 k015-0017 16.025 µM 2.21911107561501 0.0142758740158245 no 83 0.0132395843645911 132 1840002
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 2.21558333668095 0.0144022394768001 no 84 0.0133600255562191 178 115019
SGTC_1059 3448-6867 171 µM 2.20348734913621 0.0148428631033279 no 85 0.013780208831504 142 3934407
SGTC_1738 st035555 74 µM 2.19684989558968 0.0150895370437423 no 86 0.0140155841171434 204 5331140
SGTC_358 0075-0058 9.45 µM 2.18541981837241 0.0155225833354852 no 87 0.0144290395340518 269 1069125
SGTC_2280 7785178 200 µM 2.18412022863511 0.0155724891527945 no 88 0.0144767073099292 151 2954328
SGTC_1883 5-benzylidenerhodanine 20 µM 2.172219020312 0.0160359489446783 no 89 0.0149195733456495 257 1273210
SGTC_906 1165-0455 526 µM 2.17155679990185 0.0160620809018234 no 90 0.0149445542431808 126 3252859
SGTC_1957 st077035 62.4 µM 2.17118721773827 0.0160766808884236 no 91 0.0149585115948033 141 705593
SGTC_1005 4092-0690 4.4 µM 2.16730235933424 0.0162308378022746 no 92 0.0151059033636684 169 1529343
SGTC_1321 1326-2144 215 µM 2.16299379824811 0.0164032871359744 no 93 0.0152708283084654 141 3513030
SGTC_1241 0364-0022 50.8 µM 2.15630156938259 0.016674252458876 no 94 0.0155300624064047 194 4563895
SGTC_2332 7982454 138.89 µM 2.14954322931158 0.0169517722295388 no 95 0.0157956815636669 252 2981748
SGTC_170 4197-0004 226 µM 2.14780685097177 0.0170237080494827 no 96 0.0158645512776294 135 218692
SGTC_1411 3909-8223 150 µM 2.14740858428749 0.0170402444435957 no 97 0.0158803839215275 153 X1411
SGTC_2264 7948757 110.76 µM 2.12659257930236 0.0179238658729492 no 98 0.0167269748030329 181 2971411
SGTC_1474 0330-0125 5.35 µM 2.11931535983028 0.0182418603796357 no 99 0.0170319122166286 164 X1474
SGTC_701 4424-0219 185 µM 2.11354940526718 0.0184972185811764 no 100 0.0172768855275437 185 2911779
SGTC_2018 5133068 143 µM 2.10705118885061 0.0187886488688728 no 101 0.0175565713447334 209 785362
SGTC_3051 9093778 49.47 µM 2.10487044474515 0.0188873218742391 no 102 0.017651293516281 109 17217378
SGTC_2022 5136654 200 µM 2.10028997430796 0.0190960123475423 no 103 0.0178516703326845 186 1713771
SGTC_3092 9117248 49.47 µM 2.09787716084392 0.0192067285585165 no 104 0.0179579990220241 108 17141857
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 2.09486675285396 0.0193456311158748 no 105 0.0180914195429058 73 279621
SGTC_2673 kobusone 100 µM 2.08029347989035 0.0200301805540158 no 106 0.0187493112386963 116 6710676 An epoxy ketone and protein crosslinker.
SGTC_3256 9138902 49.47 µM 2.07362965411523 0.0203499819273514 no 107 0.0190568594814866 99 17228773
SGTC_2029 5175081 200 µM 2.07315511426079 0.020372919554633 no 108 0.0190789230798 222 1380876
SGTC_1951 sophoraflavanone G 9.2 µM 2.07211687904023 0.0204231807077823 no 109 0.0191272712934491 212 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_819 1013-0258 27.7 µM 2.06191896642119 0.0209224726755124 no 110 0.0196077257469503 236 5753198
SGTC_2952 9073731 13.78 µM 2.06032537092357 0.0210014213177134 no 111 0.0196837230288331 245 16457353
SGTC_2502 avocadyne acetate 18.59 µM 2.05984006617905 0.0210255139202977 no 112 0.0197069164374698 239 3952079
SGTC_1633 st005664 67.9 µM 2.05764823087249 0.0211346175483882 no 113 0.019811956612034 236 2063822
SGTC_2484 5809818 12.04 µM 2.05657910107146 0.0211880094894564 no 114 0.0198633651172475 191 2870548
SGTC_3239 9133757 49.47 µM 2.04152457973545 0.0219520219562554 no 115 0.0205993566360761 123 17036923
SGTC_989 1501-0895 10.3 µM 2.04078450425423 0.0219901728299594 no 116 0.0206361257350098 157 2830112
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 2.03051724441598 0.0225252508190118 no 117 0.0211519950612483 275 688664
SGTC_1852 st056254 31.4 µM 2.02687792220262 0.0227175307201278 no 118 0.0213374494524142 186 442583
SGTC_2607 solasodine 47.35 µM 2.02334628268122 0.0229054420088742 no 119 0.0215187291375548 257 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1889 st059080 5.18 µM 2.02157959662748 0.0229999340369964 no 120 0.0216099008321093 214 176925 Isolated from Daphnopsis sellowiana.
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 2.01835244788176 0.023173387256207 no 121 0.0217772840201274 233 5377381
SGTC_1043 0916-0009 19.3 µM 2.01578183798347 0.0233123395534645 no 122 0.0219113967677538 257 3101130
SGTC_1940 st075990 51.1 µM 2.01575066858306 0.0233140286843949 no 123 0.0219130271940803 246 1084979
SGTC_2291 7917025 104.35 µM 2.01450607962206 0.0233815596218118 no 124 0.0219782136088545 271 2964612
SGTC_1481 3346-2004 36 µM 2.0070657526061 0.0237887111433906 no 125 0.0223713311156873 197 2770522
SGTC_2122 5258151 111.688 µM 2.00629186949849 0.0238313999536988 no 126 0.0224125584897773 229 2173356
SGTC_1817 st052116 64.4 µM 2.00388165133332 0.023964764803829 no 127 0.0225413697568125 201 4361398
SGTC_1287 0971-0001 34.6 µM 1.99241601780702 0.0246078122386953 no 128 0.0231627156540856 268 4665869
SGTC_2460 5552655 174.22 µM 1.98563574517475 0.0249948506770848 no 129 0.0235368922030882 237 5401989
SGTC_2470 5664817 21.68 µM 1.97850072509765 0.0254076373148583 no 130 0.0239361234352668 185 2859561
SGTC_248 streptozotocin 5.23457 mM 1.97714800491124 0.0254865374849255 no 131 0.0240124514377843 244 5300 DNA alkylating agent.
SGTC_2622 2-methoxyxanthone 59.94 µM 1.97714740561272 0.0254865724856576 no 132 0.0240124852988137 204 71034 A hepatoprotective.
SGTC_2465 5809242 33.21 µM 1.96669421793691 0.0261032221956564 no 133 0.0246092369458422 134 2731748
SGTC_1047 2043-3044 82 µM 1.96648206605436 0.0261158654271768 no 134 0.0246214759688871 254 669592
SGTC_2942 9052777 62.25 µM 1.96399141186924 0.026264679793268 no 135 0.0247655439337441 277 6469503
SGTC_3005 9076496 71.4286 µM 1.96389219294376 0.0262706226883143 no 136 0.0247712977109442 178 21368410
SGTC_3299 9121982 43.1275 µM 1.96362162694501 0.0262868344356421 no 137 0.0247869937270881 242 17594604 YPL160W CDC60
SGTC_2297 7971671 152.32 µM 1.95640123400107 0.0267225645129942 no 138 0.0252089534602863 230 909016
SGTC_978 1416-0512 87.4 µM 1.95564085101995 0.0267688005160304 no 139 0.0252537385204087 264 6814003
SGTC_1508 1080-0625 72.9 µM 1.95058223449915 0.0270780992396645 no 140 0.0255533811196717 206 767111
SGTC_1512 0259-0544 12.2 µM 1.93777939226688 0.0278742503889712 no 141 0.0263250715009773 258 18476
SGTC_261 5-fluorouridine 15.376 µM 1.93592390861678 0.0279912365156659 no 142 0.0264385105151501 238 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1476 4112-3294 3.34 µM 1.93555259605782 0.0280146963833886 no 143 0.0264612604976625 209 704369
SGTC_912 3474-0017 2.18 µM 1.93301125019548 0.028175700867808 no 144 0.0266174059582094 248 3360550
SGTC_2343 7990716 14.84 µM 1.93136399284805 0.0282804721651944 no 145 0.0267190273684497 230 6456862
SGTC_231 b-estradiol 524 µM 1.9231449917343 0.0288080858760344 no 146 0.0272309216535242 177 450 A steroid.
SGTC_1490 4089-0339 670 nM 1.91679058040259 0.0292215904066153 no 147 0.0276322710597409 163 742542
SGTC_2224 6650123 117.647 µM 1.91109292135491 0.0295965383929386 no 148 0.0279963203358101 171 2908370
SGTC_625 k213-0058 121 µM 1.91028738877177 0.0296498691466102 no 149 0.0280481103190473 419 3655420
SGTC_36 0335-0881 14.2 µM 1.90754271239484 0.02983218116366 no 150 0.0282251727544994 353 23828853
SGTC_1819 st053448 58.6 µM 1.90536134031483 0.0299777387023001 no 151 0.0283665584630155 237 2857616
SGTC_2872 9044037 25.97 µM 1.9051509066137 0.0299918115161162 no 152 0.0283802288460194 163 6465195
SGTC_2792 7535235 81.82 µM 1.90118487524871 0.030258067230346 no 153 0.0286389007276473 246 1281891
SGTC_647 0140-0236 81 µM 1.89795580048828 0.0304762922322351 no 154 0.0288509523589834 273 990837
SGTC_1993 st073995 70.8 µM 1.89184997612397 0.0308924953037312 no 155 0.0292554862109581 224 3098394
SGTC_2956 9076196 2.52 µM 1.89110275052217 0.03094375146698 no 156 0.0293053147184694 254 16423868
SGTC_151 3013-0144 2.285 µM 1.88981016513435 0.0310325829182089 no 157 0.029391676782423 254 906558 YHR107C CDC12
SGTC_1752 st044819 83.042 µM 1.88530835619687 0.0313436132732799 no 158 0.0296941093183258 261 441209 YML126C ERG13
SGTC_2695 st077686 51.995 µM 1.88366100826915 0.0314580709970665 no 159 0.0298054219176924 249 2876092
SGTC_1174 0739-0097 51.1 µM 1.88044362176484 0.0316826114882839 no 160 0.0300238215956624 269 728447
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.87666740872389 0.0319478400200065 no 161 0.0302818460856609 309 442882
SGTC_2878 9043973 25.97 µM 1.87038179823929 0.0323933850768033 no 162 0.0307154088751651 218 6465167
SGTC_1565 sinapyl alcohol 95.1 µM 1.86230270333496 0.0329735755750651 no 163 0.031280217326917 272 5280507 A phenol propionate derived from cinnamic acid.
SGTC_3221 9128209 49.47 µM 1.86040059236426 0.0331114117080162 no 164 0.0314144354747955 227 16460723
SGTC_45 0kpi-0036 14.9 µM 1.8537111854977 0.0335999335976747 no 165 0.031890245293803 244 2795021
SGTC_823 0417-1665 178 µM 1.84989224121789 0.033881477906779 no 166 0.0321645411927943 277 3429856
SGTC_2294 7971431 200 µM 1.84704669794046 0.0340925193995552 no 167 0.0323701862952022 212 5741572
SGTC_2073 5212005 126 µM 1.84336883493559 0.0343668905024819 no 168 0.0326375885585183 166 691789
SGTC_1499 4480-0877 67.3 µM 1.84321894968231 0.0343781104149168 no 169 0.0326485246154522 199 2861909
SGTC_2945 9067681 61.76 µM 1.84139512728023 0.0345148770142137 no 170 0.0327818381804865 228 16456930
SGTC_677 0929-0063 136 µM 1.83843277645373 0.0347379731229158 no 171 0.0329993295336307 197 1539583
SGTC_1442 4112-3290 3 µM 1.82554017883295 0.0357227531058451 no 172 0.0339597768741413 283 704353
SGTC_180 1486-1293 102.781 µM 1.8223699688742 0.0359683773142343 no 173 0.0341994340535802 278 4140536
SGTC_850 0388-0143 75.9 µM 1.81111881168493 0.0368512940382311 no 174 0.0350612310800749 257 67273
SGTC_2436 5633522 8.09 µM 1.81018854888711 0.0369250813213438 no 175 0.0351332763952535 291 5724242
SGTC_2134 5324836 1.464 µM 1.80905559579167 0.037015108833147 no 176 0.0352211833064892 217 699272
SGTC_2981 9013952 38.96 µM 1.80885985413491 0.0370306811558196 no 177 0.035236389353177 286 2996344
SGTC_1905 st060207 84.5 µM 1.79605685651093 0.0380609176916022 no 178 0.0362427375154083 246 1948547
SGTC_678 1218-2179 85.9 µM 1.79156995686979 0.0384274576840665 no 179 0.036600939595718 199 6820081 YOR116C RPO31
SGTC_3247 9135149 49.47 µM 1.79028564483574 0.0385329026741027 no 180 0.0367040014048048 236 8934436 YOR116C RPO31
SGTC_1659 st012954 42.1 µM 1.7881703235617 0.0387070893801294 no 181 0.0368742663065931 248 24207262
SGTC_1250 0485-0349 40.2 µM 1.78468496487505 0.0389954910167628 no 182 0.0371562155178594 311 6842794 YDL195W SEC31
SGTC_692 k241-0027 77.8 µM 1.78159340504655 0.0392527691631767 no 183 0.0374077803403204 279 3600480
SGTC_322 k048-0136 19.3 µM 1.77555434926433 0.0397593209712049 no 184 0.0379031999932832 267 6823282
SGTC_502 l-744,832 89.3 µM 1.77458797868364 0.0398408705802883 no 185 0.0379829717979032 292 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2806 7952793 58.44 µM 1.7721816687957 0.0400445239896616 no 186 0.0381822027677062 297 2972490
SGTC_812 4251-0442 148 µM 1.77182792883256 0.0400745332809092 no 187 0.0382115624696013 250 5723007
SGTC_2038 4100038 30.985 µM 1.76702007359973 0.040484219205693 no 188 0.038612433292178 324 3596803
SGTC_1469 k284-2957 126 µM 1.76660497961219 0.0405197489894439 no 189 0.0386472032314878 250 23884841
SGTC_620 0109-0052 432 µM 1.75878404187506 0.0411939229244461 no 190 0.0393070981509728 292 493037
SGTC_2992 9074591 71.4286 µM 1.75555816751401 0.0414746332558307 no 191 0.039581940192609 269 17741321
SGTC_75 0159-0059 199.013 µM 1.75271981566693 0.0417229020682083 no 192 0.0398250563128435 283 5377270
SGTC_1425 4048-4433 7.33 µM 1.75248264255473 0.0417437018242586 no 193 0.039845425966821 324 23734946
SGTC_573 3702-0553 84.7 µM 1.74967743265006 0.0419903525096678 no 194 0.0400869949658943 290 1222756
SGTC_1254 0550-0035 264 µM 1.74796919926267 0.0421411275800482 no 195 0.0402346804980581 320 15121435
SGTC_1863 st057641 20.1 µM 1.74280535808641 0.0425995732175757 no 196 0.0406838100406436 325 3921635
SGTC_410 α-linolenic acid 100 µM 1.72950050400569 0.0437993759936693 no 197 0.0418597781841398 327 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3163 9099914 49.47 µM 1.72553475324806 0.0441622260245203 no 198 0.0422155731587164 202 16268368
SGTC_222 nsc-310342 10.666 µM 1.72320053679984 0.0443769277713825 no 199 0.0424261333534098 171 432556
SGTC_725 1497-0963 19 µM 1.72160458025067 0.0445242077815677 no 200 0.042570586461228 294 3549977
SGTC_171 k064-0041 9.68 µM 1.71944913082212 0.044723744374091 no 201 0.0427663113507365 250 53325
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.70957449258383 0.0456470943736555 no 202 0.043672292886254 316 6708514
SGTC_560 2332-1943 155 µM 1.70391768271518 0.0461829129394819 no 203 0.0441982334966599 293 21177716
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.700717271862 0.0464882891673112 no 204 0.0444980451190887 320 4330530
SGTC_2757 clomiphene 4.22 µM 1.69387805512958 0.0471463046766745 no 205 0.0451442288938709 376 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_425 3825-7017 13.1 µM 1.69355819223568 0.0471772611979511 no 206 0.0451746340857991 369 3397440
SGTC_2270 7924575 90.91 µM 1.68818336885172 0.0476998810473327 no 207 0.0456880173653976 330 1262135
SGTC_1747 st037496 66.6 µM 1.68522349010958 0.0479896578545198 no 208 0.0459727303188212 364 723305
SGTC_2534 helenine 20.12 µM 1.68209401246948 0.0482975693253691 no 209 0.0462753056277255 282 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2653 dihydrofissinolide 100 µM 1.66284405033869 0.0502264949180042 no 210 0.0481718281866323 271 6857746
SGTC_765 1319-0117 244 µM 1.66128303401715 0.0503855693112721 no 211 0.048328307906004 313 3487746 YGL099W LSG1
SGTC_2030 5175110 200 µM 1.65598840455353 0.0509281071770404 no 212 0.0488620835266091 332 2831986
SGTC_507 nimesulide 162 µM 1.65255469177144 0.0512824368764968 no 213 0.049210762809988 339 4495 A COX2 inhibitor.
SGTC_2654 protoveratrine a 100 µM 1.65116996899099 0.0514258821434163 no 214 0.0493519366820256 313 5702278 A heart drug and vasodilator.
SGTC_930 2810-3379 265 µM 1.64858265940871 0.051694760007958 no 215 0.0496165818300351 395 1015764
SGTC_3015 9080845 49.47 µM 1.64854456412198 0.0516987272711004 no 216 0.0496204868818129 351 5296973
SGTC_1619 st003326 88.7 µM 1.64235496790615 0.0523465358836201 no 217 0.0502582308238987 304 2849032
SGTC_3192 9110362 49.47 µM 1.64024439997416 0.0525688975699186 no 218 0.050477180476648 341 16649480
SGTC_2824 7998404 51.95 µM 1.63855257639101 0.0527476826657885 no 219 0.0506532379044224 333 837851
SGTC_1223 0764-0573 147 µM 1.63433396639224 0.0531955899056425 no 220 0.0510943726566542 391 1609797
SGTC_726 3448-4391 34.2 µM 1.62576796299164 0.0541143518777344 no 221 0.051999513006533 383 1356692
SGTC_1986 st071812 45 µM 1.6243270801838 0.0542701230239299 no 222 0.052153010333158 302 11838594
SGTC_2698 st077697 67.5 µM 1.62390648115685 0.0543156600321092 no 223 0.0521978845668437 338 3154499
SGTC_3196 9111891 49.47 µM 1.61831697477428 0.0549236938104518 no 224 0.0527971521575399 309 18891510
SGTC_2758 dehydroepiandrosterone 69.35 µM 1.6169471875315 0.055073518672963 no 225 0.0529448406873365 394 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_559 1550-0661 158 µM 1.61273339201345 0.0555364412446111 no 226 0.0534012213027361 342 5830875
SGTC_827 3253-0474 693 µM 1.61268805380967 0.0555414386969954 no 227 0.0534061486144925 378 5402065
SGTC_44 0929-0055 61.211 µM 1.61217179213788 0.0555983692350396 no 228 0.0534622808417852 329 1379590
SGTC_1080 nisoldipine 24.4 µM 1.60628346372603 0.0562509656708493 no 229 0.0541058209924919 380 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_40 0327-0103 19.753 µM 1.59854266733637 0.0571180392710158 no 230 0.0549611288048358 361 409036
SGTC_3311 9131146 2.8755 µM 1.59817362617067 0.0571596381461288 no 231 0.0550021707785002 423 4900406 YPR165W RHO1
SGTC_2487 5918373 44.05 µM 1.59474535794441 0.0575472183062041 no 232 0.0553845952955196 365 2876279
SGTC_2800 7887935 81.82 µM 1.5932691811008 0.0577147416792001 no 233 0.055549908656424 361 2961002
SGTC_1207 2099-0101 141 µM 1.5825702647206 0.0589403907376024 no 234 0.0567597226986086 416 5837381
SGTC_2301 7769476 200 µM 1.5788671689071 0.0593693366322788 no 235 0.0571832639636204 334 977820
SGTC_2051 5263410 176 µM 1.57376596322773 0.0599642350014397 no 236 0.0577707828055886 380 227584
SGTC_2326 6164455 177.58 µM 1.57152658438691 0.0602268595896734 no 237 0.0580301921842805 364 2888790
SGTC_602 3130-1533 38.1 µM 1.5680878212072 0.0606318945719367 no 238 0.058430319188086 435 720941
SGTC_3356 9151811 4.48 µM 1.56776625304416 0.060669879184176 no 239 0.0584678466661535 377 1859254 YPR165W RHO1
SGTC_1546 5-methoxyflavanone 78.7 µM 1.56140273582432 0.0614253922263158 no 240 0.0592143783917258 380 147795
SGTC_841 0251-0215 91.2 µM 1.55836903226491 0.0617881481629429 no 241 0.0595728966110462 464 3888614
SGTC_2409 alverine citrate 63.97 µM 1.55746983249544 0.061895990909726 no 242 0.0596794888025642 410 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1961 st076550 68.7 µM 1.55523947393339 0.0621641161645172 no 243 0.0599445231683999 343 1579337
SGTC_1628 st004252 77.7 µM 1.54987057869559 0.0628132599413137 no 244 0.0605862912813856 404 692968
SGTC_2961 9083290 32.55 µM 1.54820161102196 0.0630161244700336 no 245 0.0607868818327215 354 17741490
SGTC_759 3486-0358 89.3 µM 1.54178685557847 0.063800597155042 no 246 0.0615626986313952 438 875103
SGTC_1345 1488-0192 31.4 µM 1.54177243784302 0.0638023688440451 no 247 0.0615644510174243 399 658348
SGTC_2875 9039966 71.43 µM 1.54060134846607 0.0639464032013696 no 248 0.0617069197722908 331 6463691
SGTC_3184 9108758 49.47 µM 1.53940743568482 0.0640935048168071 no 249 0.061852429949149 346 902885
SGTC_1130 3454-2858 15.9 µM 1.53359753535994 0.0648130987908893 no 250 0.0625643475180231 439 715628 YIL048W NEO1
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.53025769516415 0.065229590170915 no 251 0.062976477678442 419 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1708 st033234 31.827 µM 1.52996868766863 0.0652657279539782 no 252 0.0630122398582844 429 674664
SGTC_1032 k061-1018 98.7 µM 1.52556853006172 0.0658178484616277 no 253 0.0635586772402461 483 4005393
SGTC_577 r071-0003 38.6 µM 1.52528983033981 0.0658529405276929 no 254 0.0635934115973675 549 4568517 YMR134W ERG29
SGTC_2614 arthonioic acid 13.39 µM 1.52455877849951 0.0659450587514129 no 255 0.0636845928035608 374 6710684
SGTC_224 benfluorex 43.875 µM 1.52420293801889 0.0659899335381016 no 256 0.0637290121682299 277 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_3085 9117376 49.47 µM 1.5218669135687 0.0662851156509247 no 257 0.0640212154950981 402 16480349
SGTC_2328 6201408 200 µM 1.51698763501234 0.0669049630506504 no 258 0.0646349029669891 401 2890418
SGTC_122 0236-0016 402.397 µM 1.51354680971059 0.0673447633320438 no 259 0.065070410182043 487 6808838
SGTC_3301 9125354 19.7965 µM 1.50794815606482 0.0680651455248543 no 260 0.0657838981622202 366 41905162
SGTC_1632 st005650 90 µM 1.50725275473196 0.0681550370369184 no 261 0.0658729413103007 405 2759605
SGTC_2936 9038235 15.59 µM 1.50569715305576 0.0683564546645441 no 262 0.0660724675751905 404 4749415
SGTC_3059 1327-0034 3 µM 1.50521986653315 0.068418345200276 no 263 0.0661337795887396 441 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_363 0455-0021 3.06 µM 1.50347589129106 0.0686448570141001 no 264 0.0663581846582479 457 4597466
SGTC_2225 6654152 15.4 µM 1.50224316941438 0.0688053145501486 no 265 0.0665171598357764 329 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_3268 9137683 49.47 µM 1.50021138983295 0.0690704125300587 no 266 0.0667798269063754 353 1953228
SGTC_1981 st071826 47 µM 1.49997669752623 0.0691010848302168 no 267 0.0668102194019801 372 11838600
SGTC_1486 3970-0793 4.53 µM 1.49977051538438 0.0691280397530536 no 268 0.0668369286804484 404 2844330
SGTC_1412 3909-8563 178 µM 1.49927826777216 0.0691924257919394 no 269 0.0669007289009002 460 23767530
SGTC_1778 st046819 58.9 µM 1.49166195085336 0.0701945389042284 no 270 0.0678938943039114 484 671715
SGTC_1265 0819-1001 68.8 µM 1.49006265480978 0.0704063766612979 no 271 0.0681038812217444 417 3106768
SGTC_909 3448-9333 149 µM 1.48968869003193 0.0704559816996188 no 272 0.0681530548923703 387 3344074
SGTC_1804 st050076 49.1 µM 1.48833492746782 0.0706357779771795 no 273 0.0683312941079277 428 3895976
SGTC_1339 1486-1321 22.7 µM 1.4835018953405 0.0712805414420344 no 274 0.0689705566277051 438 3469382
SGTC_2416 tofa 880 nM 1.48268873239805 0.0713894662386075 no 275 0.069078564828282 422 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_220 paclitaxel 373.376 µM 1.48229921254536 0.0714416884336922 no 276 0.0691303488747645 353 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.47641116633238 0.072234663266863 no 277 0.069916773438806 390 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_929 2805-0021 398 µM 1.4756688761958 0.0723351084115076 no 278 0.0700164025704355 420 3098024
SGTC_1563 conessine 56.1 µM 1.47529822689252 0.07238530394436 no 279 0.0700661914650504 519 441082 An anti-amoebic, histamine inhibitor.
SGTC_3243 9134147 49.47 µM 1.47258808179712 0.0727531392527854 no 280 0.0704310702008456 408 24282180
SGTC_1802 st050112 57.9 µM 1.47102155161469 0.0729664088458613 no 281 0.070642644292955 443 4662563
SGTC_570 0987-0065 62.6 µM 1.47016036063265 0.0730838562473192 no 282 0.0707591638250763 326 3104428
SGTC_1347 1493-0251 600 nM 1.4690032741873 0.0732418849423313 no 283 0.0709159505766679 469 3986378
SGTC_832 4083-0019 164 µM 1.46211924162035 0.0741874786344598 no 284 0.0718542683987706 642 1990758
SGTC_3057 9095946 49.47 µM 1.45758843926125 0.0748149012459657 no 285 0.0724770090491653 430 24540043
SGTC_1301 naphtanilide LB 4.81 µM 1.45175615094868 0.0756285026062179 no 286 0.0732847101087675 474 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1226 3909-7979 35.4 µM 1.45027573508542 0.0758360886768967 no 287 0.0734908213956021 501 6615510
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.44965976601138 0.0759225884881844 no 288 0.0735767103301805 430 689007
SGTC_2471 5466956 24.79 µM 1.44112706546376 0.077128566909523 no 289 0.0747743942359263 412 724419
SGTC_3053 9095903 49.47 µM 1.43725444367894 0.0776806870455079 no 290 0.0753228541216947 424 17174018
SGTC_2427 5545055 42.75 µM 1.43414225765595 0.078126562141584 no 291 0.0757658354751161 483 5372858
SGTC_699 0375-0592 111 µM 1.42870851590189 0.0789096905249308 no 292 0.0765440145749141 457 762578
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.42453384082481 0.0795153865711449 no 293 0.0771459980733414 534 688788
SGTC_3172 9105863 49.47 µM 1.42256073987453 0.0798028816903161 no 294 0.0774317659496468 341 2348785
SGTC_3046 9092212 49.47 µM 1.42202725212031 0.079880749587221 no 295 0.0775091698746707 439 25236637
SGTC_2526 patulin 37.61 µM 1.42191269191948 0.0798974782910773 no 296 0.0775257991151928 550 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1431 4049-0260 9.09 µM 1.41944828951569 0.0802579855467901 no 297 0.0778841812456632 461 3854841
SGTC_1943 st076331 65.2 µM 1.40881436923013 0.0818276854603216 no 298 0.0794450325617357 480 24208415
SGTC_1911 st060208 74.3 µM 1.40709976249319 0.0820829345181389 no 299 0.0796989042722917 516 688783
SGTC_1358 1509-0022 2.48 µM 1.39881292608875 0.0833250352702436 no 300 0.0809345445334212 487 3258434
SGTC_949 1165-0505 146 µM 1.39420319187096 0.084022069358894 no 301 0.081628127182673 523 6244267
SGTC_947 3447-0010 211 µM 1.39148412702353 0.0844352645939295 no 302 0.0820393348337289 462 748350
SGTC_2356 9061756 188.97 µM 1.38923745219187 0.0847778231248607 no 303 0.0823802782912811 448 20104043
SGTC_480 am 92016 50 µM 1.3872228287002 0.0850858852392607 no 304 0.0826869131843119 436 2129 K+ channel blocker.
SGTC_1014 4130-3005 69.3 µM 1.38684407187327 0.085143895651807 no 305 0.0827446575024746 517 743608
SGTC_3008 9078912 71.4286 µM 1.3866563446474 0.0851726589451302 no 306 0.0827732891705632 445 16648731
SGTC_1057 3448-5381 134 µM 1.38244590506384 0.0858196908308667 no 307 0.0834174146627943 512 5497911
SGTC_3079 9117512 49.47 µM 1.38241678468601 0.0858241786286773 no 308 0.0834218826653512 467 7185044
SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.3814102503472 0.0859794055695095 no 309 0.0835764279845995 532 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1775 st081588 35.1725 µM 1.37984209946639 0.0862216630480565 no 310 0.0838176335801801 537 1426443 YGL099W LSG1
SGTC_2714 st079313 56.9 µM 1.37652016654081 0.0867365411829378 no 311 0.0843303240865275 471 2939799
SGTC_2228 7354201 200 µM 1.37519917921094 0.0869419229635065 no 312 0.0845348513583534 453 753451
SGTC_1956 st077085 54 µM 1.37493154495494 0.0869835778801911 no 313 0.0845763342223613 538 24208685
SGTC_2904 7225135 42.03 µM 1.37492308517703 0.0869848948131918 no 314 0.0845776457227642 501 4446116
SGTC_966 1300-0360 30.2 µM 1.37417712670944 0.0871010766776888 no 315 0.0846933499784642 490 70588
SGTC_150 3970-0969 77.2 µM 1.37400300165168 0.0871282130587299 no 316 0.0847203752788746 586 6615640
SGTC_781 4335-2806 94.4 µM 1.36668159701753 0.0882749331591334 no 317 0.0858625643034758 562 845254
SGTC_1042 0350-0096 82 µM 1.36622688812479 0.0883465215029326 no 318 0.0859338802740639 483 3122515
SGTC_1839 st053978 48 µM 1.36388940110241 0.0887152131587535 no 319 0.0863011885570169 490 3788398
SGTC_3206 9114350 49.47 µM 1.3631845116828 0.0888266198789298 no 320 0.0864121836405401 477 17087243
SGTC_506 n9-isopropylolomoucine 153 µM 1.36301385696948 0.0888536072575176 no 321 0.0864390717475299 480 6610355
SGTC_2749 bexarotene 57.39 µM 1.36193394440903 0.0890245264595193 no 322 0.0866093662486318 508 82146 An retinoic acid receptor inhibitor.
SGTC_2047 4141938 200 µM 1.3614369670562 0.0891032659035847 no 323 0.0866878202350556 434 3807862
SGTC_1141 3253-0389 52.6 µM 1.36107551666775 0.0891605654525931 no 324 0.0867449129764458 485 5402031
SGTC_2111 5486399 200 µM 1.35748445455058 0.0897313350053928 no 325 0.0873136647989727 559 689674
SGTC_1786 berberine 21.6 µM 1.35747854133108 0.0897322770974739 no 326 0.0873146036240498 518 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2793 7325131 81.82 µM 1.35457380314914 0.0901959484648393 no 327 0.0877766922992444 462 4176441
SGTC_3280 9140961 49.47 µM 1.35443780492872 0.0902177008318741 no 328 0.0877983716511249 475 4901226
SGTC_360 0957-0399 1.01 µM 1.35235370313796 0.0905515320670515 no 329 0.0881310961541793 544 6752301 YPR165W RHO1
SGTC_1202 1988-0068 29.6 µM 1.35077986697735 0.0908042360833772 no 330 0.0883829796084164 528 2850480
SGTC_3327 9140648 26.9345 µM 1.34730284492188 0.0913643808482953 no 331 0.0889413581180075 495 8029710
SGTC_689 0833-0039 98 µM 1.34641745901416 0.0915074239516109 no 332 0.0890839617479094 530 5374726
SGTC_123 0083-0120 66.675 µM 1.34233699151787 0.0921688105845842 no 333 0.0897433772292294 539 16001701
SGTC_3335 9143315 29.6265 µM 1.34181924912921 0.0922529817199339 no 334 0.089827304654002 498 4899691
SGTC_2271 7849410 118.62 µM 1.33935846291798 0.0926538180156651 no 335 0.090227002390785 495 972430
SGTC_3091 9116372 49.47 µM 1.3389984178836 0.0927125734438219 no 336 0.0902855939791249 475 17169793
SGTC_2414 st077232 92.9 µM 1.3381495684038 0.0928512054918148 no 337 0.0904238425360834 504 729801
SGTC_3345 9148410 3.559 µM 1.33636558661977 0.0931430605433421 no 338 0.0907149043778807 465 4903596
SGTC_2990 9074105 71.4286 µM 1.33600045779106 0.0932028782143667 no 339 0.0907745618366778 470 6502001
SGTC_34 0469-0683 81.75 µM 1.33373524522645 0.0935746138484955 no 340 0.0911453197869297 501 3690923
SGTC_2903 5923464 63.88 µM 1.33324716270403 0.0936548544383933 no 341 0.0912253533891194 490 2876576
SGTC_1884 5633444 25 µM 1.33153126598467 0.0939373504953391 no 342 0.0915071321265822 553 5724239
SGTC_2399 5884133 200 µM 1.33074940359932 0.0940662804903106 no 343 0.0916357406307238 521 722445
SGTC_1648 st011736 69.8 µM 1.33072337957495 0.0940705741255967 no 344 0.0916400236231081 513 2855514
SGTC_2333 9017922 200 µM 1.32817067807164 0.0944924406886941 no 345 0.0920608643597604 519 3163164
SGTC_554 4483-2211 187 µM 1.32709771070602 0.0946701780324108 no 346 0.0922381812645726 516 747107
SGTC_1785 bathophenanthroline 24 µM 1.32010277477859 0.0958349341039315 no 347 0.0934003532397224 554 72812 An iron chelator.
SGTC_2696 st077691 74.316 µM 1.31886324770045 0.0960424277117863 no 348 0.0936074174631025 475 757133
SGTC_3227 9130768 49.47 µM 1.31466614619363 0.0967474643913635 no 349 0.0943110644705175 505 17720899
SGTC_3353 9151644 39.2805 µM 1.31397139544802 0.0968645355983498 no 350 0.0944279152471748 550 4909158
SGTC_983 1491-0821 12.2 µM 1.3119876425798 0.0971993867179983 no 351 0.094762152037386 499 46495113
SGTC_557 1315-0110 16.2 µM 1.3098345747244 0.0975637780790217 no 352 0.0951259019767267 532 6833801
SGTC_3030 9087619 49.47 µM 1.30931520227559 0.0976518279430598 no 353 0.0952138010739457 517 25236973
SGTC_493 zm226600 134 µM 1.30755625614956 0.0979504570834974 no 354 0.0955119310779722 539 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2600 tangeritin 87.95 µM 1.30344128795784 0.0986516985586427 no 355 0.0962120742356152 519 68077 A bioactive flavone.
SGTC_1733 st037357 54.9 µM 1.30342599362011 0.0986543117393767 no 356 0.0962146835161232 564 1272339 YGL099W LSG1
SGTC_1432 4049-0298 68.4 µM 1.30174220420886 0.098942312837437 no 357 0.0965022634970315 524 741646
SGTC_215 1287-0124 461.5 µM 1.30128507812583 0.0990206073025529 no 358 0.0965804464662914 459 5560863
SGTC_82 0054-0107 293.755 µM 1.30001626329888 0.0992381615557392 no 359 0.0967976975964419 515 3104697
SGTC_2001 4023502 57.655 µM 1.29977174438645 0.0992801275339447 no 360 0.0968396062324322 565 108941 YCR052W RSC6
SGTC_1672 st016598 6.51 µM 1.29858935229181 0.0994832406902236 no 361 0.0970424470096476 566 4665860 YNL267W PIK1
SGTC_6 0844-0013 19.835 µM 1.29769919683183 0.0996363532569744 no 362 0.0971953598873214 787 1584900
SGTC_2498 4'-Methoxychalcone 54.63 µM 1.29320785027402 0.100411520948756 no 363 0.0979695906392577 523 641818 YHR062C RPP1
SGTC_688 0527-0193 473 µM 1.29146037550959 0.100714306201204 no 364 0.0982720433252929 515 4007154
SGTC_3070 9117005 49.47 µM 1.2892358573146 0.101100711522678 no 365 0.0986580513284117 469 8779016
SGTC_120 rhodamine 6G 52.259 µM 1.28653364530349 0.101571545703048 no 366 0.0991284422423611 656 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1978 st071761 42 µM 1.28557904499077 0.101738256627166 no 367 0.0992950069323359 520 5147680
SGTC_1578 josamycin 24.2 µM 1.2839161413694 0.102029140880947 no 368 0.0995856493991786 509 5282165 A P450 substrate.
SGTC_2488 5268135 45.7 µM 1.28070495799068 0.102592570497279 no 369 0.100148658826454 661 1270356 YLR208W SEC13
SGTC_1006 4099-6547 255 µM 1.27644654366227 0.103343229515334 no 370 0.100898856035753 567 3146833
SGTC_3222 9128301 49.47 µM 1.27635954810043 0.103358606253424 no 371 0.100914224478017 561 4911358
SGTC_351 caspofungin 25 nM 1.27592840008967 0.103434837528918 no 372 0.10099041531409 705 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2155 5570423 76 µM 1.27463463747024 0.10366383263542 no 373 0.101219295816889 546 797402
SGTC_616 4092-0450 108 µM 1.27250776835443 0.104041086053501 no 374 0.101596382865228 589 787165
SGTC_2733 amorolfine 100 µM 1.2719906474749 0.104132960626109 no 375 0.101688221136293 440 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3080 9117754 49.47 µM 1.27180585310733 0.104165806482154 no 376 0.1017210544141 616 9550191
SGTC_1438 4092-1045 4 µM 1.27151667035356 0.104217221686868 no 377 0.101772450352038 563 1351342
SGTC_723 4182-0001 115 µM 1.27098099636451 0.10431251035712 no 378 0.101867704677308 541 744821 YLR208W SEC13
SGTC_1645 Cervolide 78 µM 1.27013522248622 0.104463089848117 no 379 0.102018233498822 514 23173 A fragrance.
SGTC_2055 5235184 200 µM 1.2700385334966 0.104480314143219 no 380 0.102035452279068 560 2836034
SGTC_1782 st039423 80.636 µM 1.26930926170417 0.104610293805895 no 381 0.10216539218336 532 2068169
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.2690450277468 0.104657417682388 no 382 0.102212502455485 605 1377
SGTC_1719 st032227 49.2 µM 1.26862604466915 0.104732171262818 no 383 0.102287235338323 550 3125804
SGTC_2731 amoxapine 43.43 µM 1.26672803973388 0.105071291406355 no 384 0.10262627516919 434 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1588 farnesol 29.9 µM 1.26579926602112 0.105237526473101 no 385 0.102792478977603 566 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1607 st000305 50.6 µM 1.26294256292977 0.105750021508051 no 386 0.103304911090333 579 5457690
SGTC_2197 6588183 93.1375 µM 1.26228960838264 0.10586741502863 no 387 0.103422297284985 515 884136
SGTC_2883 9059145 45.46 µM 1.25988847803854 0.106299919916256 no 388 0.10385479788052 539 16476510
SGTC_2168 5727979 200 µM 1.25737811530134 0.106753463319867 no 389 0.1043083749827 519 695210
SGTC_999 SEC7.066 22.7 µM 1.25626946105189 0.1069542061092 no 390 0.104509145118387 610 740511 YDR170C SEC7
SGTC_3088 9117578 49.47 µM 1.25426771344865 0.107317349752557 no 391 0.10487235753377 553 678341
SGTC_152 4469-0003 551.229 µM 1.25426004034818 0.107318743463115 no 392 0.104873751556053 567 697280
SGTC_2307 7538926 6.34 µM 1.25365411289854 0.107428842847814 no 393 0.104983876718501 605 96582
SGTC_961 1252-1571 372 µM 1.25292131607573 0.107562103631444 no 394 0.105117171744159 589 6813498
SGTC_1638 st008370 60.6 µM 1.25190651531936 0.107746844118783 no 395 0.105301965201788 587 24207134
SGTC_1126 isoteolin 1.0172 µM 1.2509994249705 0.107912169722666 no 396 0.105467343617402 573 133323
SGTC_444 curcumin 90.4 µM 1.2487517994306 0.108322607225671 no 397 0.105877934247584 610 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1603 st002045 67.8 µM 1.2483510939991 0.108395897633449 no 398 0.105951255293324 577 5887985
SGTC_2655 perillic acid 100 µM 1.2482406154472 0.108416110815781 no 399 0.105971477100764 514 5702197 An apoptosis inducer.
SGTC_142 0335-0849 62.6745 µM 1.24802299951423 0.108455933811143 no 400 0.106011317310499 705 3889043 YPR107C YTH1
SGTC_1831 st055328 12 µM 1.24479029470175 0.109048747856732 no 401 0.106604422288428 607 1103068
SGTC_2265 7929201 200 µM 1.24470267088354 0.109064848683946 no 402 0.106620531921526 573 1265108
SGTC_3290 9121031 71.43 µM 1.24466903490631 0.109071029729589 no 403 0.106626716360384 522 17014854
SGTC_1109 tnp00067 928.257 nM 1.24161119492632 0.10963399955467 no 404 0.107190024650825 602 676295
SGTC_1167 k781-0610 148 µM 1.24106302809147 0.109735141046959 no 405 0.107291233100191 637 4525169
SGTC_2120 5538279 151.968 µM 1.23938433496438 0.110045290946811 no 406 0.107601599957666 585 2058197
SGTC_600 1495-0418 41.6 µM 1.23914968471732 0.110088694215632 no 407 0.10764503498523 563 5377768
SGTC_2214 7179297 48.276 µM 1.23875515800132 0.110161697523994 no 408 0.10771809248347 567 769744
SGTC_649 1123-0311 367 µM 1.23746552336334 0.110400574057488 no 409 0.107957153095533 652 693629 YIL048W NEO1
SGTC_3254 9136651 49.47 µM 1.23716210133657 0.110456830263533 no 410 0.108013454157509 615 16454030
SGTC_2036 5160441 105 µM 1.23705849683161 0.110476043846488 no 411 0.108032683191695 664 134534 YIL048W NEO1
SGTC_2359 9039622 200 µM 1.23469751436891 0.110914540552105 no 412 0.108471550661359 627 6463596
SGTC_1560 lithocholic acid 53.1 µM 1.2342880698446 0.11099071188077 no 413 0.10854778992996 504 9903 A bile acid which acts as a detergent.
SGTC_2007 4011539 71.82 µM 1.23096255514734 0.111610764836576 no 414 0.109168434683584 605 45595301
SGTC_1625 st003711 30.1 µM 1.23064301507674 0.11167047436709 no 415 0.109228204835446 571 24207034 YER133W GLC7
SGTC_3337 9144342 33.5465 µM 1.22866872622779 0.112039898478136 no 416 0.10959801814364 597 17682949
SGTC_2379 9035213 200 µM 1.22650709045195 0.112445379592317 no 417 0.110003954360874 648 646551
SGTC_1323 1348-1351 11.2 µM 1.22638851534382 0.11246765228416 no 418 0.110026252895046 562 6989654
SGTC_3066 9117245 49.47 µM 1.22602656681925 0.112535658794253 no 419 0.110094338853857 614 17176980
SGTC_3169 9102970 49.47 µM 1.22565551612181 0.112605405997059 no 420 0.11016416838791 585 17027839
SGTC_626 0214-0009 33 µM 1.22476650988214 0.112772640009961 no 421 0.110331603305549 629 3437874
SGTC_2171 5739187 198.077 µM 1.22155780744454 0.113377714926154 no 422 0.110937446232362 517 2262761
SGTC_305 1682-2595 20.8 µM 1.22101626454133 0.113480063290468 no 423 0.111039930853973 620 226033
SGTC_845 0330-0138 4.51 µM 1.22071171720036 0.113537649849232 no 424 0.11109759488343 599 9039800
SGTC_3323 9138564 53.9225 µM 1.22062612644328 0.113553837872008 no 425 0.11111380478815 662 43912313 YNL103W MET4
SGTC_1967 st070177 51.4 µM 1.21834530624233 0.113985822243514 no 426 0.111546389970643 577 5729214
SGTC_1087 pterostilbene 9.05 µM 1.21822662384638 0.114008332538278 no 427 0.111568932463609 641 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1199 1638-0010 4.46 µM 1.21683509364649 0.114272498061819 no 428 0.111833482417104 642 3111136
SGTC_1000 4048-0884 8.67 µM 1.21431485600766 0.114752044305815 no 429 0.112313757395085 615 13040088
SGTC_1928 4'-methoxychalcone 40.3 µM 1.21270028786894 0.115060012876121 no 430 0.112622214872753 613 641818
SGTC_1516 st013856 110 µM 1.21225855042785 0.11514437377903 no 431 0.112706712544491 577 5281404 A mutagen and neurotoxin.
SGTC_903 1134-0042 114 µM 1.21223971811193 0.115147971261743 no 432 0.112710315886717 594 701009
SGTC_1609 st001574 46.4 µM 1.21134946467768 0.115318124983013 no 433 0.112880749285284 620 3960012
SGTC_2397 5161689 200 µM 1.20756027676579 0.116044349657938 no 434 0.113608223245833 646 2259942
SGTC_1104 tacrolimus 29.8 µM 1.20741264656015 0.116072709590782 no 435 0.113636633786489 652 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2222 6885208 172.143 µM 1.20512524302795 0.116512751200699 no 436 0.114077478110771 574 609514
SGTC_997 3996-0078 137 µM 1.20507792668899 0.116521866204063 no 437 0.114086610087866 638 735687
SGTC_398 bronopol 33.3 µM 1.20357672498554 0.116811319794077 no 438 0.114376609981788 619 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_373 0844-0104 25.9 µM 1.20341125269074 0.116843256427765 no 439 0.114408607756319 660 5375804
SGTC_355 1311-2252 105 µM 1.20208818351994 0.117098835224536 no 440 0.114664682022125 621 5338538
SGTC_1342 1486-1464 234 µM 1.20150848218004 0.117210941504552 no 441 0.11477700909357 642 3253938
SGTC_2005 4024620 188 µM 1.20121254381124 0.117268201225843 no 442 0.114834382399774 613 236743
SGTC_1977 st070720 65.3 µM 1.20029336686231 0.117446174774285 no 443 0.115012712495164 560 682188
SGTC_2040 5100729 123 µM 1.19988454839909 0.117525392738313 no 444 0.115092090865645 635 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2571 chrysanthemic acid 100 µM 1.19980191487936 0.117541409474971 no 445 0.115108140161597 581 2743 An insecticide.
SGTC_3274 9138298 49.47 µM 1.19914565390541 0.117668666470923 no 446 0.115235657370964 643 17015756
SGTC_2822 7994718 71.43 µM 1.19889892669439 0.117716535096183 no 447 0.115283624576485 538 1018011
SGTC_2087 5276107 200 µM 1.19834936980301 0.117823206565044 no 448 0.115390517097099 610 144405
SGTC_531 3788-1495 174 µM 1.19685015522365 0.118114558632397 no 449 0.115682482568915 617 2896655
SGTC_2704 st078022 71.1 µM 1.19619983614365 0.118241097662803 no 450 0.115809292400672 625 54697681
SGTC_2232 chlorophetanol 41.5365 µM 1.1947823241156 0.118517249132023 no 451 0.116086044058621 758 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_555 4296-0685 37 µM 1.19273652225153 0.118916603504155 no 452 0.116486288659291 634 2908540 YHR072W ERG7
SGTC_842 0271-0008 11.1 µM 1.19178325520179 0.119103011903678 no 453 0.116673121580146 665 1221709
SGTC_1348 1493-0373 93.8 µM 1.18703919220058 0.120033766411075 no 454 0.117606080851925 621 3010129
SGTC_3158 9100007 49.47 µM 1.18671929714804 0.120096711737643 no 455 0.117669180379273 547 19297233
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.18612330618009 0.120214046125932 no 456 0.117786803924839 559 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_283 0987-0079 11.7 µM 1.17978264281068 0.121467352230346 no 457 0.119043337327143 666 411556
SGTC_260 nsc-65238 3.989 µM 1.17603765132415 0.122211893908829 no 458 0.119789915371544 615 3246252
SGTC_2675 theaflavin digallate 100 µM 1.17480501606837 0.122457653475629 no 459 0.120036366441839 658 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_586 0957-0265 8.15 µM 1.17395231380592 0.122627865810549 no 460 0.120207063311771 556 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2912 7964298 10.93 µM 1.17336446752026 0.122745305474343 no 461 0.120324839952793 703 2975850
SGTC_3159 9100096 49.47 µM 1.16979181751996 0.123460744440405 no 462 0.121042378657015 626 25236875
SGTC_2492 derrusnin 100 µM 1.16827561677256 0.123765251503643 no 463 0.121347803752698 576 1715307 Part of coumarin class of compounds.
SGTC_1780 st038448 24.544 µM 1.16500272657769 0.124424355790687 no 464 0.122008944583708 641 728868 YDL195W SEC31
SGTC_2865 9030313 51.95 µM 1.16437122877228 0.124551810633394 no 465 0.122136801022343 594 42562754
SGTC_1163 k060-0048 49.9 µM 1.1621495934449 0.125000927285521 no 466 0.122587352791368 710 6809982
SGTC_1464 k208-0027 110 µM 1.16107154868874 0.125219267535151 no 467 0.122806401954254 678 X1464
SGTC_1643 st009866 20.2 µM 1.16098950771798 0.125235894482714 no 468 0.12282308318682 636 3156273 YOR207C RET1
SGTC_1450 4112-4260 37.6 µM 1.15936724412545 0.12556498943576 no 469 0.123153261319571 679 1633175
SGTC_2516 gossypol 71.55 µM 1.15728408714941 0.125988466270301 no 470 0.123578156351076 697 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1736 st036774 51 µM 1.15446657700301 0.126562809688877 no 471 0.124154466825406 690 1272247
SGTC_206 4546-0025 72.014 µM 1.15442139081106 0.12657203563213 no 472 0.124163724774678 745 6620745 YIL048W NEO1
SGTC_1387 3342-1166 1.8 µM 1.15189407183148 0.127088799886008 no 473 0.124682302284928 584 3418228
SGTC_2905 7799065 20.05 µM 1.15030235554649 0.127415012742719 no 474 0.125009680488988 625 1296806
SGTC_2892 9047358 58.44 µM 1.14775753501067 0.127937767619271 no 475 0.125534336093413 620 6466771
SGTC_633 0437-0093 97.7 µM 1.14685004166212 0.128124544086914 no 476 0.125721801573635 650 2831118
SGTC_112 phenothiazine 287.218 µM 1.14599030194026 0.12830166673047 no 477 0.125899582415416 694 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2830 7992007 71.43 µM 1.1446903448442 0.128569805241187 no 478 0.12616872621304 622 1952075
SGTC_888 0916-0002 6.97 µM 1.14437515441701 0.128634877225714 no 479 0.126234043768774 688 2802138 YIL048W NEO1
SGTC_1016 4226-1401 38 µM 1.14383796511536 0.12874583418714 no 480 0.126345420909877 683 2901613
SGTC_1673 st016611 27.3 µM 1.1408240930415 0.129369583580913 no 481 0.126971566193422 688 5226799
SGTC_2091 4-phenylthiadiazole 200 µM 1.14007193765458 0.129525575258307 no 482 0.127128166003407 680 270010
SGTC_2387 9077560 195.08 µM 1.13797445460961 0.129961266508491 no 483 0.127565574684686 667 5303272
SGTC_597 k018-0003 82.8 µM 1.13436546616735 0.130713301567668 no 484 0.128320639306484 742 6786234
SGTC_1290 0986-0249 10.2 µM 1.1339161768135 0.13080713388405 no 485 0.128414855388453 616 53329
SGTC_462 ag-879 158 µM 1.1320373093153 0.131200032350102 no 486 0.128809374600204 712 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_326 k292-0812 17.5 µM 1.13124713173166 0.131365513186401 no 487 0.128975544727384 654 3579357
SGTC_2786 7743617 45.45 µM 1.13119432313235 0.131376577621888 no 488 0.128986655391108 586 583674
SGTC_2560 caryophyllene 100 µM 1.13082936164277 0.131453061789058 no 489 0.129063459597897 728 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2790 5423970 71.43 µM 1.13029381116807 0.131565351550806 no 490 0.129176220747619 723 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.12952859697304 0.131725910139694 no 491 0.129337456500434 664 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_970 1315-0089 19.5 µM 1.12633681904007 0.13239707239624 no 492 0.130011489366029 642 6811083 YLR033W RSC58
SGTC_3052 9092717 49.47 µM 1.12471293753482 0.132739442745457 no 493 0.130355348790343 650 25237534
SGTC_5 0352-0601 109.883 µM 1.1235726645656 0.132980215807328 no 494 0.130597179013299 636 762456
SGTC_814 3342-0569 96 µM 1.12189680718962 0.13333462495554 no 495 0.130953159185509 718 4346283
SGTC_3121 9125696 49.47 µM 1.12018553079122 0.133697194506536 no 496 0.131317354262438 666 1235365
SGTC_2287 7945887 168.79 µM 1.11886506028878 0.133977426593373 no 497 0.131598855384851 730 1245853
SGTC_591 4299-0174 154 µM 1.1188293687978 0.133985006689293 no 498 0.131606469960313 675 5509088
SGTC_2922 7999257 32.47 µM 1.11859322143008 0.134035166675952 no 499 0.131656858312256 618 2988377
SGTC_868 0527-0199 213 µM 1.11763171234645 0.13423953371974 no 500 0.131862159425076 715 2849450
SGTC_1527 coumarin 137 µM 1.11710059335832 0.134352513829312 no 501 0.131975658420862 626 323 A hepatotoxic, DNA x-linker.
SGTC_1999 st074831 12.5 µM 1.11540194048299 0.134714291077825 no 502 0.132339109185789 708 17112523
SGTC_2422 chlorphenesin carbamate 384.24 µM 1.11422010565647 0.134966390986677 no 503 0.132592386025821 721 2724 A muscle relaxant with antifungal properties.
SGTC_1107 amlodipine 47 µM 1.11420168603838 0.13497032267712 no 504 0.132596336141261 689 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2371 9071574 200 µM 1.11189904327313 0.13546244348199 no 505 0.133090780059258 635 45596039
SGTC_2857 9024691 58.44 µM 1.1114748972396 0.135553225909449 no 506 0.133181994691302 645 16478292
SGTC_2877 9040724 71.43 µM 1.11135543383697 0.135578802874198 no 507 0.133207693630178 695 6463895
SGTC_924 2046-0044 21.3 µM 1.10831405068591 0.1362310729461 no 508 0.133863104717743 703 3623589
SGTC_408 cantharidin 100 µM 1.10798649090841 0.136301450912777 no 509 0.133933825078649 728 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3279 9140807 49.47 µM 1.10646177747474 0.136629371096718 no 510 0.134263349545625 699 45595718
SGTC_2391 6285546 200 µM 1.10607195837874 0.136713296027648 no 511 0.134347687420576 722 846083
SGTC_567 1080-0542 68.4 µM 1.10559889196848 0.136815190768664 no 512 0.134450084813849 641 5950415
SGTC_1815 st051655 58.2 µM 1.10517147889233 0.136907296773364 no 513 0.134542646398358 673 5984156
SGTC_1427 4048-4900 550 nM 1.10501557511387 0.13694090403148 no 514 0.134576420173821 706 24132586
SGTC_275 trichlorophene 5.69 µM 1.10495607550592 0.136953731497367 no 515 0.134589311237759 833 62616
SGTC_3097 9117246 49.47 µM 1.10478555769486 0.136990497824383 no 516 0.134626259974605 695 16423892
SGTC_426 0988-0037 14.6 µM 1.10428805427769 0.137097805944028 no 517 0.134734101534982 763 5383008
SGTC_271 rotenone 740 µM 1.1008192669087 0.137847595894044 no 518 0.135487662284653 725 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_375 3970-0961 9.27 µM 1.09261317600198 0.139632491106781 no 519 0.137281837583114 715 2898222
SGTC_3276 9139060 49.47 µM 1.08989022258749 0.140228214084771 no 520 0.137880752037885 666 4870619
SGTC_679 0422-0091 41.4 µM 1.08750782629847 0.140750844558317 no 521 0.138406220845997 756 627384 YHR062C RPP1
SGTC_1152 3909-8331 15.9 µM 1.08750316462504 0.140751868491794 no 522 0.138407250375446 681 16001939
SGTC_1559 coumarin 343 70.1 µM 1.08702041113088 0.140857932342162 no 523 0.138513894625597 677 108770 A hepatotoxic, DNA x-linker.
SGTC_3258 9138477 49.47 µM 1.08622869495507 0.141031994510044 no 524 0.138688912476798 722 4970355
SGTC_20 0481-0013 4.944 µM 1.08515507444918 0.14126826749281 no 525 0.138926489031538 707 182045
SGTC_3037 9091026 49.47 µM 1.08345913127846 0.141642042236765 no 526 0.139302340806128 810 25236398 YIL048W NEO1
SGTC_148 3253-0744 288.01 µM 1.08214767182629 0.141931538232327 no 527 0.139593457954428 695 6893655
SGTC_1764 st044502 93.5 µM 1.08206848882024 0.141949030171918 no 528 0.139611048194797 719 8407
SGTC_431 k089-0097 107 µM 1.07960750036919 0.142493403018314 no 529 0.140158500027794 774 5499420
SGTC_2227 7312221 64.1025 µM 1.07929035074815 0.142563659368036 no 530 0.140229156529313 730 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1898 st060199 18.6 µM 1.07513913204683 0.143485415228841 no 531 0.141156220911638 706 688866
SGTC_1378 2093-0007 380 nM 1.0740478178366 0.143728402085765 no 532 0.141400625219323 713 3618014
SGTC_2100 5377183 190 µM 1.07368459387894 0.143809337364122 no 533 0.14148203429494 786 2844202
SGTC_1955 wogonin 32.4 µM 1.07340582119631 0.143871475662454 no 534 0.141544536916643 712 5281703 A flavanone.
SGTC_2540 epiandrosterone 100 µM 1.07296790886111 0.1439691226816 no 535 0.141642757439779 865 441302 A steroid.
SGTC_3223 9129970 49.47 µM 1.06900000607744 0.144855934954811 no 536 0.142534833334454 766 17248386
SGTC_2062 5245942 200 µM 1.06866974219163 0.144929913226728 no 537 0.142609255175577 761 1376160
SGTC_3028 9087778 49.47 µM 1.06579680518282 0.145574516754561 no 538 0.143257752720435 736 17217395
SGTC_536 3852-0578 10.6 µM 1.06312417002759 0.146175906753007 no 539 0.143862822419079 759 2869208
SGTC_1373 2887-0003 58.5 µM 1.06310053667361 0.146181232106413 no 540 0.143868180557192 717 776948
SGTC_465 cgp-37157 41 µM 1.06197566196432 0.146434853199682 no 541 0.144123367096969 619 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_820 1582-0060 59.9 µM 1.06088651689773 0.146680699786687 no 542 0.144370738736454 751 3848840
SGTC_1704 st028805 70.8 µM 1.05919197907702 0.147063748642724 no 543 0.144756178601387 717 2876101
SGTC_297 0986-0032 24 µM 1.05771984280715 0.147397067807631 no 544 0.145091593037384 712 2847425
SGTC_3161 9100388 49.47 µM 1.05499871337904 0.148014514116132 no 545 0.145712956591737 777 25236368
SGTC_1145 3546-0597 10.2 µM 1.05453055592581 0.148120917122146 no 546 0.145820039344774 764 875334
SGTC_1591 genipin 88.4 µM 1.05406027777257 0.148227853642981 no 547 0.145927660408692 732 442424 A DNA cross-linking agent.
SGTC_2490 carminic acid 95.39 µM 1.05361089135192 0.148330087843654 no 548 0.146030550350495 662 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2154 5570129 200 µM 1.05044570976367 0.149051493955398 no 549 0.146756619636515 779 673366
SGTC_475 α-linolenic acid 10 µM 1.04881495014998 0.149424088928334 no 550 0.147131647666273 793 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3009 9080819 71.4286 µM 1.04844517878914 0.149508660461471 no 551 0.147216773778677 743 17027216
SGTC_2180 6301957 200 µM 1.04620930064113 0.150020715448469 no 552 0.147732204885295 781 845462
SGTC_2337 9009472 200 µM 1.04514261356756 0.150265416857364 no 553 0.147978530746644 780 5742383
SGTC_69 0096-0274 206.684 µM 1.04243271035133 0.150888272946998 no 554 0.148605553827932 832 6741392
SGTC_2734 clemastine 41.6 µM 1.04179273781434 0.151035617542786 no 555 0.148753890910348 640 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_795 0685-0265 78 µM 1.03954871655974 0.15155302785593 no 556 0.149274806723337 788 302754
SGTC_1209 2323-2347 50.3 µM 1.03871037482514 0.15174662866176 no 557 0.1494697273003 762 5412760
SGTC_193 1273-0060 1.558 µM 1.03828934974174 0.151843919233079 no 558 0.149567682761502 653 2847393 YHR072W ERG7
SGTC_3173 9105693 49.47 µM 1.02886840929584 0.154031750744684 no 559 0.15177075748858 800 17096658
SGTC_2369 9071472 200 µM 1.02457674192182 0.155035288271851 no 560 0.152781471686317 804 17296037
SGTC_1108 betulinic acid 729.144 nM 1.02377822617892 0.155222483673087 no 561 0.152970018512674 786 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2105 5350118 200 µM 1.02339826793261 0.155311609343284 no 562 0.15305978901019 786 2133313
SGTC_1534 6-azauridine 81.6 µM 1.02230414422827 0.155568443288527 no 563 0.153318486199915 827 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2533 agelasine 13.65 µM 1.02200492388017 0.155638730853057 no 564 0.153389284980229 808 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1085 doxorubicin 7.67 µM 1.01735408532867 0.156733916333552 no 565 0.154492507977844 842 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2415 st077333 57.7 µM 1.01643296954996 0.156951422158664 no 566 0.154711626106154 879 2766255
SGTC_799 1310-0557 151 µM 1.01341737456041 0.157664892187815 no 567 0.155430421939765 787 5354492
SGTC_2563 tomatine 8.54 µM 1.01103320322257 0.158230477359867 no 568 0.156000269194283 834 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2113 5491891 107.031 µM 1.01061395647629 0.15833007066884 no 569 0.1561006166732 796 789979
SGTC_2690 usnic acid 100 µM 1.00987033254637 0.158506821889299 no 570 0.156278709036115 848 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_707 0865-0008 204 µM 1.00850541844223 0.158831583581234 no 571 0.156605943903669 842 723043
SGTC_2652 actinonin 100 µM 1.00825078676372 0.158892217766252 no 572 0.156667041123973 776 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_3115 9123671 49.47 µM 1.00450286385052 0.159786446849772 no 573 0.157568145767788 845 3286988
SGTC_1851 st056236 18.9 µM 1.0042439431612 0.159848344926761 no 574 0.157630522997227 831 5393171
SGTC_2943 9068529 45.32 µM 1.00330771612288 0.160072292037893 no 575 0.157856207161436 873 3270634
SGTC_1368 1852-0141 284 µM 0.998902421340588 0.161128798387001 no 576 0.158920981583377 773 2838987
SGTC_1225 1216-0074 20.6 µM 0.997015629172264 0.161582689647837 no 577 0.159378461853685 808 4241466
SGTC_52 0329-0193 875 nM 0.991281425588389 0.162967234180097 no 578 0.160774090107542 776 3739292
SGTC_3234 9132280 49.47 µM 0.988656389182323 0.163603624865658 no 579 0.161415643419767 797 17612295
SGTC_1272 0839-0021 27 µM 0.985580328480194 0.164351408346004 no 580 0.16216954753672 828 5027250
SGTC_15 0266-0086 27.098 µM 0.985541827319396 0.164360781911536 no 581 0.16217899819633 919 1712902 YIL048W NEO1
SGTC_3267 9137951 49.47 µM 0.98518190017449 0.16444842722087 no 582 0.162267364799059 795 16643986
SGTC_1500 4488-1866 171 µM 0.983638663115291 0.164824561866031 no 583 0.162646603998177 868 2900003
SGTC_2011 4012611 177 µM 0.983239865487291 0.164921851728466 no 584 0.162744699269572 818 2049887
SGTC_821 1114-0266 29.2 µM 0.982069786997087 0.165207516288736 no 585 0.163032734362239 794 3123235
SGTC_2558 carylophyllene oxide 100 µM 0.980708029562723 0.165540380600733 no 586 0.163368371538835 876 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1937 st074714 47.2 µM 0.980007328018276 0.16571182710486 no 587 0.163541250709729 796 17250970
SGTC_2348 9022543 33.42 µM 0.977422899704258 0.166345173019524 no 588 0.164179915304262 834 3162678 YDL140C RPO21
SGTC_391 gliotoxin 8.33 µM 0.97548673071778 0.166820677821213 no 589 0.164659440292885 872 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1367 1812-0510 76.9 µM 0.975040630516463 0.166930359987654 no 590 0.164770053051039 815 1142582 YDR527W RBA50
SGTC_1950 st077106 7.18 µM 0.973771316745559 0.167242699165465 no 591 0.165085048962176 829 13831864
SGTC_2404 5161160 200 µM 0.97269805625587 0.16750708937116 no 592 0.1653516957972 861 2831543
SGTC_1298 1079-1278 263 µM 0.972611281745148 0.167528477423516 no 593 0.165373266711293 853 2840950
SGTC_2394 5221648 200 µM 0.972096711776045 0.16765534401099 no 594 0.165501218924396 925 788586
SGTC_3058 9093861 49.47 µM 0.968977803720492 0.168425630612997 no 595 0.166278131940936 803 17217477
SGTC_2833 9001315 45.46 µM 0.965512023565755 0.169284250441039 no 596 0.167144208328676 819 2989378
SGTC_2376 9072922 81.32 µM 0.963050806144201 0.169895700906911 no 597 0.167761013692788 851 17087968
SGTC_2691 st077356 60.2 µM 0.962340067451978 0.170072535835816 no 598 0.1679394042082 878 2839272
SGTC_1187 1391-0724 117 µM 0.959240735376465 0.170845041539532 no 599 0.168718741744241 850 6997986
SGTC_2170 morpholine 200 µM 0.958081057954797 0.171134666426906 no 600 0.169010943136928 859 121171 Reacts with secondary amines.
SGTC_1455 4262-0120 131 µM 0.958015113197675 0.171151145301317 no 601 0.169027568855 877 1529587
SGTC_2459 5811157 9.22 µM 0.955966987239072 0.171663454732508 no 602 0.169544456745351 866 2870684 YBR192W RIM2
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.954631696587715 0.171997985594118 no 603 0.169881991103644 773 6857784
SGTC_1112 tnp00069 1.16933 µM 0.952152230272616 0.172620270289279 no 604 0.17050989174904 896 145826
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.950941290308006 0.172924707330349 no 605 0.170817089908459 828 364106
SGTC_954 1189-0853 2.85 µM 0.950153884371626 0.17312284900262 no 606 0.171017033447941 888 2828194
SGTC_356 1634-0012 32.5 µM 0.950020163939371 0.173156512574092 no 607 0.171051003526136 881 735457
SGTC_2856 9022925 19.48 µM 0.950004949903964 0.173160342909359 no 608 0.171054868743508 835 4944862
SGTC_1629 st005085 44.9 µM 0.948194531598496 0.173616524980061 no 609 0.171515215258726 831 24207091
SGTC_3187 9109394 49.47 µM 0.947601931684095 0.173766011937072 no 610 0.171666071211629 845 17098090
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.946362581411211 0.174078910203671 no 611 0.171981841909608 815 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.946245825944246 0.17410840585854 no 612 0.172011608819359 847 390807
SGTC_3228 9131799 49.47 µM 0.944043248974343 0.174665432773881 no 613 0.172573773959664 828 17015818
SGTC_3310 9130229 44.1445 µM 0.941699644101972 0.175259366359643 no 614 0.173173218659094 842 7761258
SGTC_2732 terfenadine 20 µM 0.941260255552078 0.175370861839222 no 615 0.173285752425116 841 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_652 0437-0092 114 µM 0.939716727614151 0.175762890642709 no 616 0.173681441246627 848 3091274
SGTC_3098 9119039 49.47 µM 0.939557900249131 0.175803261462581 no 617 0.173722189793666 872 17161528
SGTC_3154 9100113 49.47 µM 0.938786349336143 0.17599945822364 no 618 0.17392022443779 851 25237525
SGTC_2070 5230947 200 µM 0.938428425283662 0.176090521360073 no 619 0.174012141840061 928 2835538
SGTC_539 4859-0462 2.54 µM 0.93664239645294 0.176545368958287 no 620 0.174471268000355 890 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1822 st052468 42 µM 0.936185446483128 0.176661859583317 no 621 0.174588857513696 854 2873678
SGTC_2457 5731572 11.68 µM 0.936038969893244 0.176699211263097 no 622 0.174626561810185 892 2865357
SGTC_2256 7954252 200 µM 0.93579267810283 0.176762027175991 no 623 0.174689971026879 750 2972920
SGTC_654 1124-0271 80.9 µM 0.935660799136616 0.176795668276092 no 624 0.174723930022354 877 5403748
SGTC_1959 st077091 55.8 µM 0.933651188404195 0.177308801967096 no 625 0.175241925674671 894 821356 YKL052C ASK1
SGTC_24 0417-1663 219 µM 0.929021779132163 0.178494448855013 no 626 0.176438899785905 858 4329390
SGTC_1485 3909-9022 254 µM 0.927849604853277 0.178795447184891 no 627 0.176742794316694 938 714516
SGTC_2458 5808907 16.39 µM 0.927687363600588 0.178837133679463 no 628 0.176784882571901 950 2731747
SGTC_2210 7115885 190.385 µM 0.927568732179058 0.178867618874782 no 629 0.176815661674036 890 2927039
SGTC_1611 st001856 99.4 µM 0.925585225381975 0.179377813070198 no 630 0.177330787226202 841 647478
SGTC_2058 5236698 133 µM 0.924641125626077 0.179620973855797 no 631 0.177576306659436 846 766665
SGTC_2102 5377816 72.7585 µM 0.924253859892062 0.179720777266233 no 632 0.177677079712688 919 1379702
SGTC_225 nsc-122657 1.016 µM 0.923829971915707 0.179830058634905 no 633 0.177787423843927 758 275685
SGTC_3140 9094243 49.47 µM 0.923423043758907 0.179935006899592 no 634 0.17789339375052 961 19291112
SGTC_599 1935-0052 86.5 µM 0.921170607637879 0.180516613902921 no 635 0.178480680586503 916 9557311
SGTC_3352 9151559 45.5865 µM 0.919759835508521 0.18088149267382 no 636 0.178849138238484 854 17159339
SGTC_860 0443-0016 25.1 µM 0.919081677468112 0.181057054259988 no 637 0.179026426066503 947 5337942
SGTC_2546 rhodinyl acetate 100 µM 0.917436296809969 0.181483454036698 no 638 0.179457029993594 922 6708682
SGTC_384 k007-0144 5.16 µM 0.917341933173725 0.181507927381263 no 639 0.179481745129909 921 6824886
SGTC_837 0091-0265 12.5 µM 0.914210505893481 0.182321238958476 no 640 0.180303122407746 911 759367
SGTC_459 nigericin 15.3 µM 0.913747489750281 0.182441689022982 no 641 0.180424771983416 948 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1594 piperine 70.1 µM 0.912727468695501 0.182707214935218 no 642 0.180692946690674 887 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_51 1013-0126 23.419 µM 0.909414647098564 0.183571252437565 no 643 0.181565646559849 874 1627850
SGTC_1711 st032263 62.8 µM 0.90893194319558 0.183697361646211 no 644 0.1816930255546 872 3958979
SGTC_213 1246-0773 967 nM 0.908785412388573 0.183735654350843 no 645 0.181731704101847 916 6251622
SGTC_2133 5320837 200 µM 0.90855904023787 0.183794821664383 no 646 0.181791467845788 835 2841355
SGTC_2166 5933061 31.504 µM 0.906194896725392 0.184413451316362 no 647 0.182416351843188 908 2877375
SGTC_1558 st069300 45.6 µM 0.905946558815382 0.184478509436066 no 648 0.182482069638346 846 24208000
SGTC_1330 1469-0054 61.8 µM 0.905909491972313 0.184488221216081 no 649 0.18249187992531 953 7102664
SGTC_2456 5770359 74.46 µM 0.904219831823877 0.18493126195031 no 650 0.1829394231463 937 3118787
SGTC_1458 k015-0034 6.33 µM 0.900639035553097 0.185872354762881 no 651 0.183890136311243 869 3598957
SGTC_2869 9037858 32.47 µM 0.899462129710483 0.186182312553879 no 652 0.184203279336687 924 27187042
SGTC_1569 carminic acid 40.6 µM 0.899185598043549 0.186255188232683 no 653 0.184276905106833 941 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2929 9013348 24.6 µM 0.898996799772807 0.18630495327277 no 654 0.18432718262735 868 2995952
SGTC_2033 5192550 145 µM 0.898578040963329 0.186415362648439 no 655 0.18443872975514 882 182073
SGTC_753 1322-0200 289 µM 0.897595004105357 0.186674708012127 no 656 0.184700751729767 937 5403907
SGTC_3014 9081533 49.47 µM 0.896330968074266 0.187008514838961 no 657 0.185038012096788 921 21367265
SGTC_1429 4049-0205 9.46 µM 0.89473211890199 0.187431267745878 no 658 0.185465152364507 955 22774478
SGTC_1947 st076332 61.6 µM 0.894472492182616 0.18749997154641 no 659 0.185534570609451 899 24208416
SGTC_2026 5148700 152 µM 0.894031892580607 0.187616600963523 no 660 0.185652413759628 923 79838
SGTC_1414 3917-0015 5.4 µM 0.893721351188404 0.187698830097429 no 661 0.18573549932286 928 6618702
SGTC_2071 5230951 39.92 µM 0.892985826415687 0.18789368057685 no 662 0.185932381480635 993 1799272
SGTC_1168 k815-0004 80.5 µM 0.892926618567592 0.18790937096799 no 663 0.185948235612651 914 642433
SGTC_770 0389-1121 67.2 µM 0.892459322735349 0.188033235209367 no 664 0.186073393197973 980 6753108
SGTC_3120 9124077 49.47 µM 0.89186418394342 0.188191059223889 no 665 0.186232867024032 951 18774327 YGL155W CDC43
SGTC_2885 9057732 51.95 µM 0.891399134837409 0.188314441815142 no 666 0.186357540853319 927 6471414
SGTC_2234 tolnaftate 200 µM 0.890276218375542 0.188612569445178 no 667 0.186658793760915 904 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2163 5671233 125 µM 0.889288556385174 0.188875028196329 no 668 0.186924010038269 971 701023
SGTC_2317 5986382 200 µM 0.888802849789104 0.189004181119364 no 669 0.187054522023507 951 877883
SGTC_917 harmaline 728.087 nM 0.887844549347517 0.189259159694796 no 670 0.187312187799512 909 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1428 4049-0204 61.7 µM 0.887362618868666 0.189387468728969 no 671 0.187441851123082 972 X1428
SGTC_2314 7727897 200 µM 0.886854767618278 0.189522736823497 no 672 0.187578548443032 914 900724
SGTC_1364 1653-0028 37.6 µM 0.886317742750999 0.189665840070627 no 673 0.187723165356694 902 5718652
SGTC_2195 6536160 144.242 µM 0.884641924997501 0.190112829343266 no 674 0.18817489357389 855 3834386
SGTC_2699 st077704 54.6 µM 0.884480553584552 0.190155905929389 no 675 0.188218427728541 906 645852
SGTC_681 1642-0006 26.6 µM 0.884345393666214 0.19019199021764 no 676 0.188254895429745 938 4446530
SGTC_1033 k072-0102 21.3 µM 0.88357510490338 0.190397718185298 no 677 0.188462811410922 935 5965931
SGTC_2090 5301565 104.445 µM 0.883001943757935 0.190550886146142 no 678 0.188617610652767 954 2056344
SGTC_2059 5238311 157 µM 0.882783536397892 0.190609271847981 no 679 0.188676618687364 879 703021
SGTC_3000 9075062 71.4286 µM 0.878647590841966 0.191716984689869 no 680 0.189796191649233 878 17057871
SGTC_1212 0520-0165 585 µM 0.87813232540245 0.191855261679362 no 681 0.189935956194804 906 5403258
SGTC_695 3505-6186 243 µM 0.876586680230321 0.192270418222273 no 682 0.190355588256855 933 1819379
SGTC_2276 7947513 42.08 µM 0.875715586946764 0.192504633673411 no 683 0.190592334798775 884 2105100
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.875388128209036 0.192592724321452 no 684 0.190681378564053 1032 91467 include heat shock
SGTC_2630 antimycin a 100 µM 0.874488264948672 0.192834926063218 no 685 0.190926204098804 1000 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_3130 9127414 49.47 µM 0.873110296613218 0.193206172097454 no 686 0.191301481064754 938 1494646
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.873075448199927 0.193215566452691 no 687 0.191310977566479 935 140250 A respiratory chain inhibitor.
SGTC_1624 st003710 6.25 µM 0.872967589432687 0.193244644538361 no 688 0.191340371868334 995 24207033
SGTC_191 3914-0123 66.505 µM 0.871396956268374 0.193668380518262 no 689 0.191768723569601 814 3144412
SGTC_2203 7227154 166.4 µM 0.869500126455744 0.194180874633537 no 690 0.192286819464723 981 896304
SGTC_1826 st055655 41.6 µM 0.869044790656475 0.194304022166708 no 691 0.192411316179498 948 676168
SGTC_2585 alliin 100 µM 0.868228029302931 0.194525037925853 no 692 0.192634756376846 953 87310 A garlic compound which reacts with lipids.
SGTC_1853 st056710 91.2 µM 0.867606336448018 0.194693370628768 no 693 0.192804938216949 1016 269167
SGTC_1190 1486-1332 13 µM 0.866375894255105 0.195026792552453 no 694 0.193142029426181 949 4150046
SGTC_3191 9110352 49.47 µM 0.865749650684329 0.195196623573256 no 695 0.193313732811795 925 17122424
SGTC_2157 5649910 96.377 µM 0.865441092801733 0.19528033443904 no 696 0.19339836741833 931 2858091
SGTC_2766 oltipraz 83.91 µM 0.86416359238037 0.195627148673098 no 697 0.193749014606376 922 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1656 st012921 11 µM 0.859890386775141 0.19678994803416 no 698 0.194924734080668 896 6732821
SGTC_173 1273-0061 2.693 µM 0.8589532388917 0.197045517652603 no 699 0.195183157558778 922 2847414 YPL266W DIM1
SGTC_3249 9135183 49.47 µM 0.857230611275148 0.197515819145481 no 700 0.195658724021389 991 4902779
SGTC_2300 7976697 71.57 µM 0.856324614182103 0.19776344115062 no 701 0.195909125017261 854 2236109
SGTC_2106 5357045 167.29 µM 0.85552584168513 0.197981912658553 no 702 0.196130052304928 956 668842
SGTC_2081 5214970 32.255 µM 0.854728171916815 0.198200227960882 no 703 0.19635082531025 984 2063512
SGTC_1880 MG-132 525 µM 0.854534081134322 0.198253370900336 no 704 0.19640456706664 915 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_254 nsc-64875 3.808 µM 0.853571313930591 0.198517108062142 no 705 0.196671279244967 1003 56993
SGTC_690 glyoxal 20.3 µM 0.853233221174084 0.198609774227026 no 706 0.196764991974649 918 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_952 1185-0122 232 µM 0.851375202393937 0.199119494844421 no 707 0.197280481106125 968 678600
SGTC_3147 9097027 49.47 µM 0.850456631233312 0.199371782424615 no 708 0.197535631176883 1007 25236841
SGTC_568 1193-0097 7.48 µM 0.847577000113653 0.200163925891005 no 709 0.198336793899015 952 3646150
SGTC_99 0109-0120 622.8 µM 0.845879801870449 0.200631684452396 no 710 0.198809900634056 953 759414
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.844664960436574 0.200966905079126 no 711 0.199148964196699 1063 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1269 0831-0796 3.05 µM 0.844651758144211 0.200970549934845 no 712 0.199152650883147 991 927758
SGTC_816 0325-0417 81.3 µM 0.84337532445427 0.201323131784231 no 713 0.199509283906353 979 68101
SGTC_1509 1326-1131 80 µM 0.843181364522782 0.201376740641839 no 714 0.199563509547594 952 768313
SGTC_612 0302-0167 22.4 µM 0.84290941952119 0.201451918308685 no 715 0.199639552515311 1042 235821
SGTC_1816 st051957 91.6 µM 0.840377733214136 0.202152595527681 no 716 0.20034831489251 994 674121
SGTC_3134 9127454 49.47 µM 0.838987945801722 0.202537856485799 no 717 0.200738036977027 1020 24262820
SGTC_2957 9076800 11.52 µM 0.83821254759785 0.202752994124822 no 718 0.200955670591499 908 16459615
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.836655850572317 0.203185318570839 no 719 0.20139302111289 915 2374 Ca(2+)-ATPase inhibitor.
SGTC_1386 3228-0095 33.8 µM 0.832989585948962 0.204205681786889 no 720 0.202425301312582 967 870181
SGTC_281 1672-3440 14.9 µM 0.832934362873972 0.204221074289342 no 721 0.202440874170665 1031 6833000
SGTC_724 3910-0327 137 µM 0.8309359994548 0.204778549217883 no 722 0.203004892740888 1016 2885483
SGTC_270 tamoxifen 5.46 µM 0.829598607772321 0.205152140705478 no 723 0.203382882096832 1057 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2720 fluspirilene 36.88 µM 0.829224279561098 0.205256779306946 no 724 0.203488754304231 932 3396 An atypical antipsychotic.
SGTC_3211 9128781 49.47 µM 0.829205963730256 0.205261900073704 no 725 0.203493935461109 906 17194361
SGTC_1331 1472-0049 76.2 µM 0.825902379447326 0.20618676186581 no 726 0.20442973536375 986 24051409
SGTC_401 neomycin 50 µM 0.825796344773238 0.206216487884519 no 727 0.204459813966199 971 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3167 9103034 49.47 µM 0.824736240012027 0.206513819873296 no 728 0.204760676131936 988 5127859
SGTC_956 1185-0240 191 µM 0.822807253944468 0.207055501638709 no 729 0.205308805461338 987 1416193
SGTC_110 0850-0284 111.64 µM 0.821964208277096 0.207292502414664 no 730 0.205548633806949 883 3906265
SGTC_2864 9034755 47.6 µM 0.821879828947714 0.207316232337772 no 731 0.205572647063242 1054 4930451
SGTC_1614 st002383 48.6 µM 0.821810797637661 0.207335647145672 no 732 0.205592293712014 1019 1947235
SGTC_782 0083-0095 30.5 µM 0.819332956790774 0.20803324253927 no 733 0.20629823714715 1069 3591729 An indicator and reagent.
SGTC_504 lovastatin 124 µM 0.818531790111356 0.208259093932069 no 734 0.206526798655309 996 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_928 2764-0428 58.7 µM 0.818153496907513 0.20836578623013 no 735 0.206634772464499 1028 662578
SGTC_3295 9122362 53.5725 µM 0.817970713166978 0.208417349373613 no 736 0.206686955234866 977 4730473
SGTC_3198 9112019 49.47 µM 0.816572398900236 0.20881206161556 no 737 0.207086416873242 1013 45595555
SGTC_328 k915-0120 63.5 µM 0.8162558645579 0.208901473146172 no 738 0.207176905773169 1003 6624543
SGTC_258 haloperidol 50.781 µM 0.815237790885557 0.209189201545171 no 739 0.207468104974332 1002 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1725 st036284 20.55 µM 0.814039250247063 0.209528232425621 no 740 0.207811232937538 1066 707914
SGTC_3123 9126162 49.47 µM 0.813939581559324 0.209556440231071 no 741 0.20783978198709 1073 25239884
SGTC_389 tpck 16.7 µM 0.813345455957802 0.209724633454278 no 742 0.208010011079973 1002 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1696 st025591 34.7925 µM 0.813244645911088 0.209753180019444 no 743 0.208038903378342 1031 2787147
SGTC_2244 6635614 200 µM 0.812888050643394 0.209854176084401 no 744 0.208141123082213 864 836499
SGTC_1657 st012939 43.4 µM 0.812616016890097 0.209931241580921 no 745 0.208219122759018 999 24207257
SGTC_1433 4060-0023 7.6 µM 0.809355762124516 0.210856145209894 no 746 0.20915527009934 1024 3840627
SGTC_2247 cerulenin 830 nM 0.808126721498506 0.211205431750356 no 747 0.209508818152713 1041 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_446 go6976 132 µM 0.80711852365267 0.21149220895285 no 748 0.209799100484371 1025 3501 A protein kinase C inhibitor.
SGTC_2178 5812956 200 µM 0.806120271723731 0.211776381604095 no 749 0.210086751991914 1056 5403383
SGTC_1929 genistein trimethyl ether 50.5 µM 0.805107062470016 0.212065040511765 no 750 0.210378950330294 1065 136420
SGTC_2181 6316240 54.2555 µM 0.804833291392018 0.212143076164956 no 751 0.21045794380483 991 12779990
SGTC_1855 st056195 39.6 µM 0.80338473118537 0.212556252808786 no 752 0.21087619875116 987 4028379
SGTC_1701 st028638 40.4 µM 0.803280238393317 0.212586075727636 no 753 0.210906388668917 1049 3490878
SGTC_711 k292-0785 179 µM 0.802230340053738 0.212885859112845 no 754 0.211209864520926 1080 4146315
SGTC_3156 9099931 49.47 µM 0.800599922164076 0.213351890262158 no 755 0.211681647908661 1071 18111053
SGTC_737 1950-0117 57.9 µM 0.800174598268676 0.21347356063059 no 756 0.211804822472374 1043 5393513
SGTC_764 1951-2361 146 µM 0.799400465819563 0.213695116745417 no 757 0.212029120218148 989 5438930
SGTC_2680 butyl paraben 22.24 µM 0.798750387571283 0.213881272068185 no 758 0.212217581659211 1064 7184 An antifungal and steroid mimetic.
SGTC_274 sirtinol 40.1 µM 0.796512308852236 0.214522886227723 no 759 0.212867162028783 1074 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_104 0074-0074 590.992 µM 0.796307820655173 0.214581564802072 no 760 0.212926570523704 917 3943124
SGTC_1699 st031318 29.054 µM 0.796036274673464 0.214659500251739 no 761 0.213005475791231 1079 5340658
SGTC_2447 5741742 33.78 µM 0.793067051877278 0.215512759141291 no 762 0.213869378944432 1052 1776504
SGTC_3074 9116018 49.47 µM 0.792569431943008 0.215655951283966 no 763 0.214014362116657 1043 17027303
SGTC_611 3453-1652 23.7 µM 0.792452739342897 0.215689538032938 no 764 0.214048369160803 1079 1560575
SGTC_32 0928-0142 34.1 µM 0.792329433626766 0.215725031480138 no 765 0.214084306844073 1048 2244242
SGTC_810 3825-7150 143 µM 0.792209893148445 0.215759444338926 no 766 0.214119150493739 1102 22330411 YGL099W LSG1
SGTC_284 0988-0104 32.6 µM 0.79039112340992 0.216283417237985 no 767 0.214649692295428 1074 4666532
SGTC_775 4577-0580 57.3 µM 0.788771311976137 0.216750691434157 no 768 0.215122839804564 1065 2006902
SGTC_1568 digitonin 820 nM 0.787888311748144 0.217005660094205 no 769 0.215381019275577 1079 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2528 xanthyletin 44.79 µM 0.787321527864077 0.21716941174258 no 770 0.215546835282414 1041 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3122 9126309 49.47 µM 0.782703511190048 0.218506277804353 no 771 0.216900619939048 1136 17591206
SGTC_2450 5739737 12.93 µM 0.781269614302823 0.218922337647775 no 772 0.21732196876433 1030 2262825
SGTC_553 k007-0256 45.7 µM 0.781218126019663 0.218937285970638 no 773 0.21733710731848 1090 6287000
SGTC_2517 totarol 10 µM 0.781143366900379 0.218958991438257 no 774 0.217359089033874 1040 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2687 chenodiol 100 µM 0.780734220066792 0.219077804531401 no 775 0.217479414809641 1029 5702181 A cholesterol synthesis inhibitor.
SGTC_883 0850-0245 24.6 µM 0.779288107893001 0.219498041344809 no 776 0.217905009175426 1079 6823229 YPR165W RHO1
SGTC_2282 7944268 200 µM 0.777062322149028 0.220145753472215 no 777 0.218561001001331 1065 2970414
SGTC_2066 5222451 176 µM 0.776125628534684 0.220418662280177 no 778 0.218837406391773 1123 2281147
SGTC_334 1502-1024 68.5 µM 0.776033454761475 0.220445527891895 no 779 0.218864616468534 1115 3296216
SGTC_898 1000-0849 28.3 µM 0.775625518795637 0.220564450287588 no 780 0.218985064210636 1086 6751807
SGTC_1838 st055369 84.5 µM 0.773930862504645 0.221058873585445 no 781 0.219485838769592 1087 676036
SGTC_750 4073-0104 132 µM 0.773882468580975 0.221073002030259 no 782 0.219500148932319 910 22330957
SGTC_1870 st057514 26.5 µM 0.773504067543919 0.221183492767562 no 783 0.219612061218536 1082 5393161
SGTC_1233 0325-0408 14.2 µM 0.77324065021482 0.22126042762834 no 784 0.219689986359926 1058 12874
SGTC_2709 st078560 56 µM 0.771782225712754 0.221686658580178 no 785 0.220121710359434 1078 17250903
SGTC_316 k060-0003 58.6 µM 0.771603135729052 0.221739030735842 no 786 0.220174758247355 1092 6152314
SGTC_3217 9129673 49.47 µM 0.771218826466701 0.221851440020164 no 787 0.22028861847383 1052 17248312
SGTC_1380 2291-0730 164 µM 0.771028923247019 0.221906998144283 no 788 0.220344894016126 1057 2999191
SGTC_1756 st041558 35.5 µM 0.769798103279981 0.222267279660452 no 789 0.220709832505296 1172 3955792
SGTC_2923 7992654 58.14 µM 0.769537900413539 0.222343488089972 no 790 0.220787027037753 1073 2985126
SGTC_2344 7990960 76.95 µM 0.769310705861089 0.222410041205109 no 791 0.220854441616503 1025 140813
SGTC_1102 cgs 12066b 26.1 µM 0.769238565304002 0.222431176037246 no 792 0.220875850075668 1032 6438352 A 5-HT1B full agonist.
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.769154257709724 0.222455876866218 no 793 0.220900870734933 1102 165506
SGTC_1856 st057054 55.7 µM 0.768386674119229 0.222680839003553 no 794 0.22112874746573 1112 1266018
SGTC_719 2810-4230 27.3 µM 0.764213093849747 0.223906292009234 no 795 0.222370132421749 1076 721079
SGTC_1355 1499-0035 1.68 µM 0.764147823702568 0.223925487115502 no 796 0.222389577818041 1079 1548538
SGTC_2719 novobiocin 32.65 µM 0.763646471326685 0.224072959538843 no 797 0.222538973928115 1073 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2897 9048598 12.99 µM 0.762604737122765 0.224379561211495 no 798 0.222849579301681 1092 6467404
SGTC_1564 D-Arginine 115 µM 0.758599711232068 0.22556052955789 no 799 0.224046022744599 1091 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2261 9010538 184.68 µM 0.753919883029823 0.226944923901043 no 800 0.225448665354833 1046 6457250
SGTC_179 1273-0063 6.77 µM 0.752658243364744 0.227318962621533 no 801 0.225827654175297 1086 3108139
SGTC_2612 dictamnine 15.46 µM 0.752015800077608 0.227509561382415 no 802 0.226020778568572 1044 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_990 3985-0011 41.3 µM 0.751088937231643 0.227784699679394 no 803 0.226299566549988 1045 5399565 YGL099W LSG1
SGTC_331 k048-0133 24.5 µM 0.750476724767897 0.227966536976274 no 804 0.226483818371216 1105 6813582
SGTC_1352 1496-0991 99 µM 0.750289806761117 0.228022071004032 no 805 0.226540090198008 1122 3000039
SGTC_2887 9044784 58.44 µM 0.749521587123453 0.228250391769297 no 806 0.226771446246115 1161 6465546
SGTC_3307 9126885 69.2785 µM 0.746851030681327 0.229045100700484 no 807 0.22757674400395 1115 24824909
SGTC_1396 3511-0007 98.6 µM 0.746354900541595 0.229192910778172 no 808 0.227726527626888 1065 X1396
SGTC_772 k072-0172 35.3 µM 0.745495102324919 0.229449193671195 no 809 0.227986235420739 1085 5861980
SGTC_1914 st062367 72.6 µM 0.745492422614361 0.229449992672343 no 810 0.227987045105557 1067 978205
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.743993193448663 0.229897257673951 no 811 0.228440296472499 1282 16725076
SGTC_321 4534-3890 65.3 µM 0.743723749535553 0.229977692577486 no 812 0.228521809186387 1145 699746
SGTC_1392 3455-1037 33.9 µM 0.743376483090997 0.23008138243654 no 813 0.228626889023413 1115 981132
SGTC_1762 st045503 25.4615 µM 0.742702445374802 0.230282717167266 no 814 0.228830924463303 1160 4645554
SGTC_63 0099-0242 26.702 µM 0.742052779311725 0.230476865309472 no 815 0.229027679144772 1154 3898502 YLR359W ADE13
SGTC_409 arachidonic acid 100 µM 0.740549298856199 0.230926520571325 no 816 0.229483379652354 1163 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2710 st078562 53.7235 µM 0.737757179675525 0.2317628750031 no 817 0.230331009223041 1130 17250908
SGTC_209 4077-0173 175.592 µM 0.737388866287021 0.231873325847918 no 818 0.230442952093622 1053 15993494
SGTC_3102 9121669 49.47 µM 0.737194332956194 0.231931674874652 no 819 0.2305020896107 1138 41905072
SGTC_1837 st055472 66.5 µM 0.736295640883131 0.232201337921444 no 820 0.230775399237801 1173 676091
SGTC_3171 9103192 49.47 µM 0.73582049116914 0.232343982622013 no 821 0.230919974564813 1191 13018434
SGTC_2768 sulfasalazine 50.2 µM 0.733849762606277 0.232936135147714 no 822 0.23152015398414 1160 5384001 An antioxidant and salicylic acid derivative.
SGTC_2321 7390090 138.78 µM 0.730565779036233 0.233924746226264 no 823 0.232522210432808 1095 649046
SGTC_1779 st039427 55 µM 0.730285041565786 0.234009367213465 no 824 0.232607984849564 1198 1124498
SGTC_2811 7967822 32.47 µM 0.730123895989968 0.234057948002483 no 825 0.232657228002794 1127 2232244
SGTC_2838 9002687 71.43 µM 0.730112831051473 0.234061283970368 no 826 0.232660609459076 1106 6457060
SGTC_1214 0358-0031 63.7 µM 0.729201785443957 0.234336045402401 no 827 0.23293911961244 1129 4301366
SGTC_1262 0737-0114 49.6 µM 0.728280083669454 0.234614202175519 no 828 0.233221075742478 1186 765919
SGTC_809 3998-0021 90 µM 0.727876755254122 0.234735978491418 no 829 0.23334451676945 1101 715485
SGTC_1964 st076914 61 µM 0.727232779971431 0.234930485360292 no 830 0.233541684311229 1167 24208661
SGTC_2649 anisomycin 9.56 µM 0.726633320549633 0.235111626630807 no 831 0.233725305323101 1113 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3288 9119690 36.221 µM 0.726129611188932 0.235263894312523 no 832 0.23387965889331 1123 17595618 YKL019W RAM2
SGTC_3112 9123419 49.47 µM 0.724998083727895 0.235606145292614 no 833 0.23422660301262 1206 17015854
SGTC_294 k038-0071 157 µM 0.724822040750967 0.235659417358227 no 834 0.234280606159442 1154 24152826
SGTC_359 0081-0058 15.9 µM 0.723104211885538 0.23617959517946 no 835 0.234807930912815 1173 3494159
SGTC_2242 6630449 61.2675 µM 0.723048363450147 0.236196517319315 no 836 0.234825085803747 1079 691249 YDR170C SEC7
SGTC_3185 9108267 49.47 µM 0.722436906430443 0.236381833169304 no 837 0.235012951564111 1144 4910486
SGTC_588 3970-1144 52.9 µM 0.721964879631276 0.236524946271253 no 838 0.235158035168648 1094 1888707
SGTC_418 lividomycin a 100 µM 0.72173761992917 0.236593865802372 no 839 0.235227904044133 1186 72394 An antibiotic.
SGTC_779 1360-0071 233 µM 0.720788527003646 0.23688181026324 no 840 0.235519817668471 1231 7566
SGTC_1426 4048-4480 71.7 µM 0.718905698784597 0.237453609649876 no 841 0.236099512469474 1151 14224343
SGTC_1227 3909-8010 46.6 µM 0.717718409919562 0.237814568659742 no 842 0.236465464791376 1127 15982272
SGTC_79 0052-0007 94.094 µM 0.716482330940041 0.238190680329827 no 843 0.236846786920243 1187 2801472
SGTC_2911 7942208 15.64 µM 0.714049340402862 0.2389319370157 no 844 0.237598335004793 1152 1243384
SGTC_777 1315-0167 517 µM 0.713701609329181 0.239037982810119 no 845 0.237705855531104 1126 4221767
SGTC_1116 jasmonic acid 1.58368 µM 0.713020491212688 0.239245774509925 no 846 0.237916538650335 1195 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2924 9010168 62.78 µM 0.71284928454802 0.239298020797225 no 847 0.237969512308863 1191 2993929
SGTC_3252 9135871 49.47 µM 0.711326228286171 0.239763078557073 no 848 0.238441051032077 1210 17682838
SGTC_2044 5102272 200 µM 0.710704454741918 0.239953075716245 no 849 0.238633699284655 1149 592666
SGTC_1046 2001-0062 216 µM 0.710688046363158 0.239958090784245 no 850 0.238638784355649 1110 739778
SGTC_354 2783-3500 4.88 µM 0.709548938722284 0.240306388102351 no 851 0.238991946670597 1153 6740761
SGTC_1336 1486-0901 104 µM 0.708659240471921 0.240578616646693 no 852 0.239267982177643 1173 5006114
SGTC_1452 4194-0072 190 µM 0.706708821234052 0.241175990058104 no 853 0.239873723277085 1208 1343545
SGTC_439 amiodarone 34.4 µM 0.706265199313637 0.241311974817943 no 854 0.240011615472045 1137 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_975 1335-0046 28.5 µM 0.70573905969073 0.241473307969669 no 855 0.240175212879613 1169 16486740
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.703705688680118 0.24209736230116 no 856 0.240808038472092 1222 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_733 4069-0007 56.1 µM 0.7030920354728 0.242285867961247 no 857 0.240999197643459 1206 5717425 YNL287W SEC21
SGTC_511 blebbistatin 171 µM 0.702818012104172 0.242370069781918 no 858 0.241084585335763 1199 3476986 A myosin inhibitor.
SGTC_1267 0828-0272 9.49 µM 0.702608978843897 0.242434312120334 no 859 0.241149732691595 1200 745334
SGTC_847 0342-0274 5.54 µM 0.702218063566377 0.242554477139098 no 860 0.241271591119164 1210 18097
SGTC_1055 3448-0672 86 µM 0.701458050922501 0.242788192770009 no 861 0.241508602508229 1163 748378
SGTC_2836 9010338 19.48 µM 0.701383210807509 0.242811213851883 no 862 0.241531948377273 1118 2994051
SGTC_1354 1498-1681 81 µM 0.70047626810414 0.243090286486675 no 863 0.241814960427223 1218 5754243
SGTC_2818 7996756 12.99 µM 0.699989759888552 0.243240059928029 no 864 0.241966849749611 1191 2241621
SGTC_1243 0416-0003 5.65 µM 0.698009657447599 0.243850156481692 no 865 0.24258557724807 1182 2141977
SGTC_2575 plumbagin 510 nM 0.697852725998738 0.243898544494421 no 866 0.242634650620302 1156 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2988 9073640 71.4286 µM 0.695891220788095 0.244503789001563 no 867 0.243248477867859 1218 9102229
SGTC_1335 1486-0900 202 µM 0.695684580082205 0.244567597393042 no 868 0.243313192195837 1216 X1335
SGTC_2431 5490079 200 µM 0.695641280046064 0.244580969107492 no 869 0.243326753785132 1230 5722345
SGTC_1148 3909-7663 27.7 µM 0.695453817365185 0.244638864997472 no 870 0.243385471887084 1245 4084526
SGTC_237 nikkomycin 200 µM 0.693151879784095 0.245350395715836 no 871 0.244107121415624 1223 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_3178 9107506 49.47 µM 0.689688797238179 0.24642292924734 no 872 0.245194956179428 1222 8897194
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.689536807479754 0.246470058704507 no 873 0.245242759337104 1251 94937 An inhibitor of serotonin biosynthesis.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.689437335729531 0.246500905828956 no 874 0.245274047471789 1202 616764
SGTC_427 1354-0053 47.3 µM 0.688211099185013 0.246881343168815 no 875 0.245659927714986 1245 6813657
SGTC_1018 4259-0013 28.1 µM 0.687901681413588 0.246977389018903 no 876 0.245757348836593 1196 6801262
SGTC_743 1275-0778 158 µM 0.684606238241067 0.248001561266883 no 877 0.246796214735275 1206 2849257 YMR203W TOM40
SGTC_3082 9117008 49.47 µM 0.683769133180345 0.248262080909226 no 878 0.247060480330466 1229 41448529
SGTC_3138 9097216 49.47 µM 0.682805507387753 0.248562156273978 no 879 0.247364874570189 1233 25237486
SGTC_1909 st060837 51.5 µM 0.681582696829208 0.248943220397139 no 880 0.247751429609269 1182 678937
SGTC_1381 2324-0066 62.1 µM 0.681376833825078 0.249007403992503 no 881 0.247816538756489 1212 10885928
SGTC_3077 9117319 49.47 µM 0.679834356290859 0.249488594873602 no 882 0.248304675030415 1230 17154678
SGTC_2937 9044753 11.33 µM 0.679273057994817 0.249663819881019 no 883 0.24848243200845 1235 6465530 YGL099W LSG1
SGTC_2190 6049624 200 µM 0.678352144020209 0.249951450546496 no 884 0.24877422213573 1154 2265554
SGTC_3255 9139072 49.47 µM 0.675586392604906 0.250816338586655 no 885 0.2496516416554 1243 17646060
SGTC_508 roscovitine 141 µM 0.674837572324264 0.251050777124356 no 886 0.24988948324269 1260 160355 A CDKinase inhibitor.
SGTC_414 piperonyl butoxide 100 µM 0.674829809276079 0.251053208164591 no 887 0.24989194958517 1208 5794 A potent inhibitor of cytochrome P450.
SGTC_2395 5646831 180.19 µM 0.674490759476595 0.251159395579903 no 888 0.249999679274407 1240 6808628
SGTC_1864 st057645 30.4 µM 0.674096793269769 0.251282812163438 no 889 0.250124889051947 1260 688666
SGTC_2529 gangaleoidin 93.61 µM 0.673944935826083 0.251330392638929 no 890 0.250173161048626 1274 4565183
SGTC_2152 5568786 200 µM 0.67393566637858 0.251333297127047 no 891 0.25017610775328 1208 5399883
SGTC_2475 5812728 15.03 µM 0.673410176585901 0.251497983079603 no 892 0.25034318806813 1237 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_942 3253-1115 227 µM 0.672247137386389 0.251862676585957 no 893 0.250713188470299 1272 46497897
SGTC_1873 rapamycin 2 nM 0.67114327670253 0.252209071560596 no 894 0.251064629960548 1233 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2726 cimetidine 79.27 µM 0.670281866760368 0.252479559148541 no 895 0.251339062174642 1224 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1029 k015-0030 64.7 µM 0.670204195426028 0.252503955897222 no 896 0.251363814881924 1258 2208316
SGTC_113 0099-0221 2.5 µM 0.667245271794183 0.253434285010329 no 897 0.252307738947362 1274 89219
SGTC_1205 4161-2785 76 µM 0.665741323720363 0.253907837965688 no 898 0.252788227658895 1220 3498106
SGTC_130 0136-0219 337.655 µM 0.664131777410706 0.254415154956139 no 899 0.253302986603039 1209 234244
SGTC_1077 5-fluorocytosine 377 nM 0.65935543454109 0.255923744029347 no 900 0.25483377637967 1247 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_23 0213-0011 39.996 µM 0.658489906514916 0.2561976163614 no 901 0.255111690365365 1282 627608
SGTC_2809 7964133 12.99 µM 0.658453261573557 0.256209215007425 no 902 0.255123460253847 1256 1253665
SGTC_1118 chelidonine 707.474 nM 0.658256891684958 0.256271373539004 no 903 0.255186536599589 1269 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1879 gemcitabine 100 µM 0.657443512867501 0.256528922535117 no 904 0.255447890376866 1272 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3025 9087895 49.47 µM 0.657427427151141 0.256534017289961 no 905 0.255453060427405 1262 17173641
SGTC_617 3770-0098 35 µM 0.657329348773707 0.256565082343005 no 906 0.255484584618515 1227 5962639
SGTC_2812 7970281 58.44 µM 0.655744414498152 0.257067361238397 no 907 0.255994293268375 1284 2233435
SGTC_3029 9088683 49.47 µM 0.655656639663473 0.257095192753982 no 908 0.256022536807124 1254 25236615
SGTC_530 4358-1714 28 µM 0.654858674199471 0.257348282330634 no 909 0.25627937479057 1287 1564641
SGTC_668 1682-0499 62.6 µM 0.65354365074444 0.257765648784486 no 910 0.256702929049467 1274 682214
SGTC_21 0849-0113 22.993 µM 0.652485980245946 0.258101590462719 no 911 0.257043857076725 1237 1560156
SGTC_2816 7982706 58.44 µM 0.649935607433639 0.258912583188399 no 912 0.25786690826019 1271 2981853
SGTC_2769 toremifene 3.73 µM 0.647699702520262 0.259624661241958 no 913 0.258589598345706 1286 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1240 0356-0016 42.1 µM 0.647051788352126 0.2598311939682 no 914 0.258799213239845 1264 4305613
SGTC_3109 9122853 49.47 µM 0.645529545844446 0.260316765780454 no 915 0.259292038888667 1340 1234709
SGTC_2067 5224629 34.075 µM 0.64262376077112 0.26124496254674 no 916 0.260234130738568 1265 2835000
SGTC_320 4092-0846 5.34 µM 0.64230461417191 0.26134701128855 no 917 0.260337709458647 1258 1359356
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.63933870791387 0.262296353176251 no 918 0.26130130627501 1323 5024745
SGTC_2098 5376439 882.5 nM 0.638744928272124 0.262486625077812 no 919 0.26149443993973 1330 2844116
SGTC_2826 7992541 19.48 µM 0.637660009689798 0.262834460896112 no 920 0.261847511397309 1344 2985066
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.637326188033773 0.262941534882235 no 921 0.261956198118321 1319 23847180
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.636200444606233 0.263302783740653 no 922 0.262322891708713 1315 1273210
SGTC_131 0141-0277 33.849 µM 0.636127911529902 0.263326068150905 no 923 0.26234652725362 1278 1547771
SGTC_2674 ligustilide 100 µM 0.635110758241278 0.263652703206307 no 924 0.262678090500903 1255 5319022 A signalling regulator.
SGTC_3332 9141069 11.198 µM 0.634998347468655 0.263688813983574 no 925 0.262714746389943 1248 17332883
SGTC_936 3005-4620 401 µM 0.634966587605616 0.26369901696228 no 926 0.262725103398271 1340 777207
SGTC_1730 st033808 45.1 µM 0.634327110809807 0.263904494190449 no 927 0.262933683569262 1316 1045166
SGTC_2440 5628896 157.78 µM 0.633885371975547 0.264046481736543 no 928 0.263077816345792 1325 5522048
SGTC_583 1488-1091 88.9 µM 0.631702683252288 0.264748631455532 no 929 0.26379058718292 1371 4303273
SGTC_866 0495-0101 262 µM 0.631042602422037 0.264961159850316 no 930 0.26400633453276 1251 635694
SGTC_1093 fluphenazine 7.97 µM 0.629247959062895 0.265539425018435 no 931 0.26459336777205 1338 6602611 An atypical antipsychotic.
SGTC_1809 st050081 57.6 µM 0.626526098328215 0.266417675779041 no 932 0.265484962098753 1353 5036894
SGTC_1840 st055363 71 µM 0.626425593191632 0.266450133438541 no 933 0.265517913517261 1244 676033
SGTC_776 4476-4378 112 µM 0.623112450998785 0.267521215708885 no 934 0.266605314103152 1297 2892008
SGTC_806 3966-4455 5.86 µM 0.621876336448311 0.267921385787827 no 935 0.267011593098715 1236 714982
SGTC_1678 st019265 80.2 µM 0.621084507811096 0.268177884522656 no 936 0.267272010958635 1345 5367020
SGTC_3072 9116419 49.47 µM 0.619850635680682 0.268577821499654 no 937 0.26767806408374 1267 17170162
SGTC_3237 9133362 49.47 µM 0.619846490871094 0.268579165468528 no 938 0.267679428616672 1304 43845137
SGTC_1297 1068-0111 14.1 µM 0.615943570975308 0.269846198990103 no 939 0.268965881726267 1265 767057
SGTC_2136 5328288 199.296 µM 0.611407563314688 0.271322506836436 no 940 0.270464898391711 1296 262395
SGTC_2974 9094440 9.66 µM 0.610578628467637 0.271592729768636 no 941 0.270739287369618 1422 25236134
SGTC_1690 st023502 41.2 µM 0.608188330522957 0.272372688160513 no 942 0.2715312866671 1329 24207482
SGTC_741 4582-0002 126 µM 0.60528149297958 0.273322691176094 no 943 0.272495988075517 1305 2912688
SGTC_1922 5578187 25 µM 0.604899846373684 0.273447541421381 no 944 0.272622772622918 1412 1350412
SGTC_1218 1348-1416 30.7 µM 0.604187902957557 0.273680518992627 no 945 0.272859361335042 1323 6787668
SGTC_2621 lithochol-11-enic acid 100 µM 0.604165601618763 0.273687818506451 no 946 0.272866774025106 1344 6708711
SGTC_2635 hydroquinidine 100 µM 0.603546590265133 0.273890467280256 no 947 0.27307256561945 1355 442912 An experimental heart treatment.
SGTC_3135 9127742 49.47 µM 0.603535562278135 0.273894078238737 no 948 0.273076232593695 1330 3643468
SGTC_1391 3442-0225 151 µM 0.603101500842599 0.274036224212216 no 949 0.273220584038797 1326 5227075
SGTC_477 mead ethanolamide 10 µM 0.601798283707759 0.274463219268009 no 950 0.273654208859084 1235 16061185
SGTC_2448 5185112 27.17 µM 0.598854332748409 0.275429002626448 no 951 0.274635013424075 1317 5718189
SGTC_1707 st032323 6.317 µM 0.597353961908066 0.275921851967041 no 952 0.275135542006295 1306 3132057 YMR211W DML1
SGTC_1915 st067105 30.6 µM 0.595767224649825 0.276443542259463 no 953 0.275665370986996 1314 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_460 trequinsin 123 µM 0.594828883988544 0.276752279005724 no 954 0.275978929070668 1379 5537 A vasodilator.
SGTC_2521 angolensin 13.4 µM 0.593314546364904 0.277250888677774 no 955 0.276485332789162 1381 821428 A flavenoid.
SGTC_1439 4092-1168 46 µM 0.592754610912905 0.277435363812435 no 956 0.276672693925605 1356 2886240
SGTC_1651 st011928 86.1 µM 0.592636918804665 0.277474146032301 no 957 0.276712083032125 1355 720198
SGTC_1654 st012436 41.8 µM 0.592059102295094 0.277664588112577 no 958 0.276905506077636 1331 4323132
SGTC_2250 alverine citrate 130 µM 0.592009498422121 0.277680939988708 no 959 0.276922113970816 1284 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1760 st045453 10.4495 µM 0.590877843738448 0.27805411674715 no 960 0.277301136173838 1372 3323419 YIL048W NEO1
SGTC_126 0417-1624 672.48 µM 0.590459724304814 0.2781920585393 no 961 0.277441240001508 1410 41912 YDL195W SEC31
SGTC_1012 4112-3522 18 µM 0.590182532711033 0.278283525215764 no 962 0.277534140674376 1356 3112398
SGTC_2117 5521686 200 µM 0.590031980730517 0.278333209955205 no 963 0.277584604491607 1327 803312
SGTC_1454 4239-0054 42.6 µM 0.588173988790119 0.278946734905957 no 964 0.278207757315016 1441 1340767
SGTC_1652 st011932 78 µM 0.587780125275428 0.279076876494546 no 965 0.278339942967497 1367 1551076
SGTC_2425 5628681 7.85 µM 0.587654579779255 0.279118365826311 no 966 0.278382084081143 1366 5714958
SGTC_2586 curcumin 80 µM 0.585426841031875 0.279855070483701 no 967 0.279130372629958 1401 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2160 5660466 132.927 µM 0.585198594889717 0.279930603838988 no 968 0.279207094790684 1320 2859134
SGTC_293 4049-0273 38.5 µM 0.584923022076337 0.28002181215126 no 969 0.279299738891497 1301 1380311
SGTC_2721 ifenprodil 61.44 µM 0.584287408743602 0.28023224057726 no 970 0.279513481010683 1379 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_646 4092-0839 27.3 µM 0.579854161299182 0.281702053946123 no 971 0.28100648486312 1442 877796
SGTC_1129 3453-1384 223 µM 0.579552439966037 0.281802222552206 no 972 0.281108236749077 1448 1084452
SGTC_971 1315-0384 26.7 µM 0.57873014091906 0.282075305107031 no 973 0.281385637513605 1361 6769120
SGTC_83 0170-0301 39.027 µM 0.57825289875703 0.282233853928103 no 974 0.281546694665143 1344 3089716
SGTC_370 0180-0345 38.7 µM 0.577895990740191 0.282352453507304 no 975 0.281667171142365 1344 3989527
SGTC_29 0299-0004 12.984 µM 0.577613369915288 0.282446384657717 no 976 0.281762589156418 1277 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2217 6934799 96.0675 µM 0.577526827079448 0.282475150823384 no 977 0.281791810733005 1361 675606
SGTC_1248 0469-0687 58.6 µM 0.576563601131748 0.28279541470496 no 978 0.282117146853465 1419 4017482
SGTC_1932 st074806 40.9 µM 0.57542589364938 0.283173916648964 no 979 0.282501648085241 1461 17251235
SGTC_1811 st050069 61.5 µM 0.575134048360929 0.283271049311706 no 980 0.282600321126378 1372 3877702
SGTC_1845 st056753 3.01 µM 0.574468996320606 0.283492453236992 no 981 0.282825237430907 1310 5375839
SGTC_314 1671-0008 2.74 µM 0.572691319106802 0.28408467042378 no 982 0.283426858103559 1313 3913060
SGTC_2323 6148992 148.28 µM 0.572417914300305 0.284175805255439 no 983 0.283519441106823 1342 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1921 5740136 50 µM 0.570761067789642 0.284728385649197 no 984 0.284080808453939 1467 1774243
SGTC_835 0312-0010 67.2 µM 0.570709121454774 0.284745718732623 no 985 0.284098417334578 1355 1626196
SGTC_2132 5317594 122.667 µM 0.570270741918433 0.284892014151173 no 986 0.284247040964528 1417 794577
SGTC_1328 1441-0025 69.2 µM 0.568311197831255 0.285546388484469 no 987 0.2849118383901 1303 4562601
SGTC_13 0199-0087 65 µM 0.56422072356767 0.286914670948989 no 988 0.286301962935668 1414 4589825
SGTC_392 N-ethylmaleimide 8.33 µM 0.563302018740099 0.287222408606654 no 989 0.286614621855399 1353 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_353 1988-1175 58.3 µM 0.563115256885687 0.287284987144466 no 990 0.286678201526367 1323 2788357
SGTC_3329 9141233 27.5565 µM 0.562722115053654 0.287416738771215 no 991 0.286812061352849 1472 4909101 YNL103W MET4
SGTC_1810 st050138 53 µM 0.561422677272449 0.287852415978493 no 992 0.28725471414742 1387 3444541
SGTC_1774 st048371 48.465 µM 0.559717251957426 0.288424686070854 no 993 0.287836156511621 1352 4242727
SGTC_1908 st060353 56.5 µM 0.558529678306833 0.288823503072 no 994 0.28824137218706 1502 4227716
SGTC_3067 9117431 49.47 µM 0.557106358544374 0.289301831242553 no 995 0.28872738171122 1401 17150885
SGTC_1743 st037606 46.3785 µM 0.556452400631262 0.289521728457186 no 996 0.288950812749321 1438 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_499 genistein 192 µM 0.555772936870436 0.28975028527158 no 997 0.2891830442457 1440 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.554915999822054 0.290038660897774 no 998 0.289476058766395 1407 97141
SGTC_893 0958-0369 48.9 µM 0.550538075985106 0.291514010831331 no 999 0.290975184246977 1495 6819948
SGTC_403 arphamenine a 50 µM 0.550353396436659 0.29157632426358 no 1000 0.291038503431998 1404 5487158 An arginine aminopeptidase inhibitor.
SGTC_641 4092-0595 30 µM 0.549077619897984 0.292006958449786 no 1001 0.291476091582188 1430 786260
SGTC_965 1291-5240 308 µM 0.548797119215772 0.292101680230027 no 1002 0.29157234375078 1471 2834598
SGTC_2229 7354935 190 µM 0.547471844071152 0.292549403331544 no 1003 0.292027304469982 1412 318112
SGTC_788 1182-0090 188 µM 0.543226138845964 0.29398589011466 no 1004 0.293487055822317 1564 5715185
SGTC_757 1066-0008 322 µM 0.542053664651654 0.294383157513514 no 1005 0.293890768683596 1479 6842497
SGTC_3203 9113543 49.47 µM 0.540812957607495 0.294803813841799 no 1006 0.294318255350456 1471 17018012
SGTC_2153 5569715 200 µM 0.539798455744046 0.29514798208438 no 1007 0.294668016084669 1444 2054701
SGTC_1502 4534-4282 27.7 µM 0.539259272822607 0.295330974347447 no 1008 0.294853983346344 1420 3278949
SGTC_2249 haloperidol 116.36 µM 0.537819070236549 0.295820017736135 no 1009 0.295350982465234 1450 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_852 0418-0143 439 µM 0.537474318482753 0.295937138762281 no 1010 0.295470009908607 1445 5369229
SGTC_1459 k035-0031 35.7 µM 0.536836659027471 0.29615382415018 no 1011 0.295690223471714 1330 3877128 YMR208W ERG12
SGTC_374 0880-0231 82.3 µM 0.535655600125745 0.296555356240105 no 1012 0.296098297320132 1402 6833587
SGTC_948 3448-0295 75.3 µM 0.535057824984546 0.296758680669912 no 1013 0.296304936197609 1444 678569
SGTC_3286 9117135 37.221 µM 0.533943246859559 0.297137958374087 no 1014 0.296690399991 1384 3438150
SGTC_1679 SEC14.276 6.7 µM 0.533544136643326 0.297273824709694 no 1015 0.296828483398908 1486 1005053 YMR079W SEC14
SGTC_2978 9011784 42.97 µM 0.533533423311162 0.297277472166624 no 1016 0.296832190382932 1554 2994934
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.533008912082936 0.297456072061044 no 1017 0.297013705551672 1428 15053
SGTC_1253 0550-0034 176 µM 0.53262531253977 0.297586721514552 no 1018 0.29714648820114 1429 5969915
SGTC_1180 1193-0155 285 µM 0.53172255021884 0.297894294959359 no 1019 0.297459085633496 1409 2921347
SGTC_3062 9077494 49.47 µM 0.531315332371158 0.298033082547805 no 1020 0.297600141152389 1460 16459633
SGTC_176 1486-1328 72.834 µM 0.530791835471443 0.298211543525274 no 1021 0.297781519217827 1425 22310231
SGTC_1318 1280-3875 124 µM 0.530165853787187 0.298425005606546 no 1022 0.297998471767615 1431 373245
SGTC_201 4262-0159 12.803 µM 0.529392315016744 0.298688881210661 no 1023 0.298266664078706 1454 1341029
SGTC_2236 dapsone 200 µM 0.525540876381439 0.30000429012731 no 1024 0.299603622589285 1432 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1635 st007035 42.4 µM 0.521700319587666 0.30131858623762 no 1025 0.300939501065247 1473 3716403
SGTC_807 1315-0151 48 µM 0.520752331918459 0.301643400362358 no 1026 0.301269656808771 1542 4011080
SGTC_1814 st052110 31.539 µM 0.520366825736818 0.301775533447831 no 1027 0.30140396371861 1510 674163
SGTC_1705 st027868 56.3335 µM 0.518603541624192 0.302380234305482 no 1028 0.302018619414237 1515 292948
SGTC_1795 st049545 62.3 µM 0.518548449227734 0.302399136450969 no 1029 0.30203783290443 1463 5291882
SGTC_317 4495-0002 170 µM 0.518522573367074 0.302408014615479 no 1030 0.302046857308236 1413 15991618
SGTC_522 1273-0010 11.6 µM 0.518367931001648 0.302461075784315 no 1031 0.302100792536899 1488 5705015
SGTC_1757 st041620 31.8375 µM 0.517180773832541 0.302868554257488 no 1032 0.302514985963337 1425 5289815
SGTC_478 N-arachidonylglycine 10 µM 0.516431967973051 0.30312569985941 no 1033 0.302776371583148 1447 5283389
SGTC_2423 st077119 87.2 µM 0.513189685778196 0.304240249083672 no 1034 0.303909320069142 1400 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1366 1683-0113 21.9 µM 0.513188941065112 0.304240505291744 no 1035 0.303909580510794 1454 708623
SGTC_1156 4092-0367 4.88 µM 0.513118811681495 0.304264632751292 no 1036 0.303934106660654 1466 1357585
SGTC_3113 9123498 49.47 µM 0.511327723985535 0.304881130863424 no 1037 0.304560797535077 1499 8897275
SGTC_509 pifithrin 175 µM 0.510462895928502 0.305179006013645 no 1038 0.304863601357198 1540 4817 A p53 inhibitor.
SGTC_3340 9146634 11.102 µM 0.510113806131595 0.305299280572544 no 1039 0.304985866690867 1465 4907387
SGTC_908 3448-7491 47.7 µM 0.509697949125511 0.305442586384985 no 1040 0.305131545014073 1451 1203031
SGTC_1210 3013-0140 750 nM 0.509348658399137 0.305562976260625 no 1041 0.30525392845407 1593 905973
SGTC_1311 1190-0148 100 µM 0.50799093189989 0.306031142846662 no 1042 0.305729851330966 1558 1961333
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.507438230935079 0.306221814136079 no 1043 0.305923683274604 1491 4213774
SGTC_1973 st070275 50.2 µM 0.505333226342596 0.306948480947354 no 1044 0.306662404785645 1445 17118334
SGTC_2684 capsaicin 100 µM 0.505080138739982 0.307035900273279 no 1045 0.306751275285559 1456 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_815 1582-0027 36.9 µM 0.505019358558651 0.307056896070541 no 1046 0.306772619647204 1532 3128206
SGTC_834 0312-0008 75.7 µM 0.504599816567653 0.307201839159367 no 1047 0.306919969354115 1490 6385573 YIL048W NEO1
SGTC_2507 purpurin 79.67 µM 0.504428235718434 0.30726112547825 no 1048 0.306980240220601 1405 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_758 0868-0029 16 µM 0.503140051430967 0.307706392503764 no 1049 0.307432904687699 1560 762687
SGTC_1767 st044992 70.3 µM 0.502846985247924 0.307807731816566 no 1050 0.307535928349552 1412 9600693
SGTC_87 0100-0052 35.5 µM 0.502442716868531 0.307947547783153 no 1051 0.307678068635822 1539 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.501697238211969 0.308205444218357 no 1052 0.307940253756676 1465 4620898
SGTC_2582 agaric acid 100 µM 0.501454883751591 0.308289306530468 no 1053 0.308025511041014 1363 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_47 0149-0135 24.25 µM 0.501359325379008 0.308322375502005 no 1054 0.308059130136254 1369 5239155
SGTC_1483 3453-0561 55.9 µM 0.500888175954493 0.308485444412078 no 1055 0.308224912231423 1513 4546991
SGTC_1876 myriocin 605 nM 0.500575365332169 0.308593731761079 no 1056 0.308335001688078 1576 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_662 k832-1615 104 µM 0.499838838501136 0.308848764985088 no 1057 0.308594280387613 1532 5878478
SGTC_563 tetrahydrosecaminediol 614 µM 0.499746892825783 0.308880609000073 no 1058 0.308626654623882 1579 334274 A psychoactive constituent of the cannabis plant.
SGTC_210 3551-0445 56.827 µM 0.499143053796677 0.309089775343573 no 1059 0.308839304378765 1518 2865180 YOR207C RET1
SGTC_661 1304-0007 33.6 µM 0.49691647517819 0.309861583877141 no 1060 0.309623976478198 1471 3117130
SGTC_101 0490-5701 117.494 µM 0.495990743653466 0.310182721261989 no 1061 0.309950470816909 1522 4661669
SGTC_675 1309-0189 238 µM 0.495765085222382 0.310261024406288 no 1062 0.310030080561218 1448 4246530
SGTC_315 k915-0449 187 µM 0.49563332954978 0.310306747409179 no 1063 0.310076566592106 1543 20970215 YNL149C PGA2
SGTC_1930 st074634 34.3 µM 0.495376388922432 0.310395921620975 no 1064 0.310167229105477 1431 684253 YOR116C RPO31
SGTC_3104 9120930 49.47 µM 0.494945420866847 0.310545519086714 no 1065 0.3103193237929 1478 17014836
SGTC_428 3448-4153 16.5 µM 0.494911940448191 0.310557142108891 no 1066 0.310331140861969 1417 3834874
SGTC_880 0833-0487 87.2 µM 0.494096794011349 0.310840185706872 no 1067 0.310618910972909 1470 76075
SGTC_337 1315-0038 354 µM 0.491681961032682 0.311679345717371 no 1068 0.311472096238901 1479 1626437
SGTC_1213 1315-0166 115 µM 0.491100039357736 0.311881711370611 no 1069 0.311677846839392 1440 768401
SGTC_673 1082-0474 110 µM 0.489633446773543 0.312391976843959 no 1070 0.312196652128126 1472 3098046
SGTC_2676 harmalol 100 µM 0.487300900763536 0.31320427118679 no 1071 0.313022554739289 1551 5459187 A monoamine oxidase inhibitor
SGTC_1849 st056239 19.2 µM 0.486917410420252 0.313337906207188 no 1072 0.313158430132233 1403 5393181
SGTC_2366 9070441 60.58 µM 0.486909799983246 0.313340558467063 no 1073 0.313161126861438 1447 6837235
SGTC_864 0469-0573 172 µM 0.486867037002427 0.313355461672263 no 1074 0.31317627994573 1466 689425
SGTC_1453 4237-0541 195 µM 0.484389160416859 0.314219539246876 no 1075 0.314054854880975 1568 739892
SGTC_3349 9149703 23.001 µM 0.483200376125583 0.314634450570558 no 1076 0.314476734155057 1459 4910494
SGTC_534 k292-0788 63.4 µM 0.482923919175784 0.314730973581331 no 1077 0.314574878770332 1571 4146317
SGTC_2486 5283202 22.39 µM 0.480866119499727 0.315449837418448 no 1078 0.315305826899877 1467 1377751
SGTC_172 1112-0046 2.638 µM 0.478569132483288 0.316253083748099 no 1079 0.316122591027321 1528 2802135 YIL048W NEO1
SGTC_383 2324-0395 7.37 µM 0.474033554061327 0.317841701839501 no 1080 0.317737989956148 1581 3146421
SGTC_2013 4024628 200 µM 0.473635186126 0.317981393865996 no 1081 0.317880039798059 1544 5230760
SGTC_476 mead acid 10 µM 0.472885442523747 0.318244369808882 no 1082 0.318147455683645 1541 5312531 An omega 9 fatty acid.
SGTC_1723 st034307 2.5525 µM 0.472215349096565 0.318479485651108 no 1083 0.318386542482277 1523 867466
SGTC_1821 st053465 65.6 µM 0.469922809065971 0.319284422272247 no 1084 0.319205083839246 1482 675086
SGTC_3273 9137859 49.47 µM 0.469881993717648 0.319298760735899 no 1085 0.319219664784087 1573 2377234
SGTC_1892 st058411 7.36 µM 0.469321544099861 0.319495674449896 no 1086 0.319419909039089 1596 3934738
SGTC_309 k408-0051 1.48 µM 0.468816373129356 0.319673209664762 no 1087 0.319600447808188 1523 3640463
SGTC_1142 3253-1408 9.78 µM 0.468748676009761 0.319697004004035 no 1088 0.319624644757686 1528 256655
SGTC_1923 st058458 19.1 µM 0.46863930406614 0.319735447874283 no 1089 0.319663739142215 1643 3534982
SGTC_286 k060-0067 22.9 µM 0.467551939737033 0.320117758063353 no 1090 0.320052520324927 1504 5985051
SGTC_2419 paclitaxel 166.5 µM 0.466623500208892 0.320444342579946 no 1091 0.320384635300111 1535 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1522 st012842 45.6 µM 0.466226959131287 0.320583870833796 no 1092 0.320526527107935 1444 3491067 YOR116C RPO31
SGTC_802 4112-3352 742 µM 0.464087358046909 0.321337155052829 no 1093 0.321292579379994 1627 704594
SGTC_195 4234-0266 16.654 µM 0.463256662690443 0.321629814363327 no 1094 0.321590202713817 1515 2303354
SGTC_1247 0448-0043 5.84 µM 0.461416465108053 0.322278521923028 no 1095 0.322249920425049 1543 3089013 YGL099W LSG1
SGTC_656 4090-1979 187 µM 0.46129957479597 0.322319746482305 no 1096 0.322291844986468 1637 22330961
SGTC_2408 sulbentine 18.36 µM 0.459694562132768 0.322886018843445 no 1097 0.322867736634858 1618 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2780 5215298 71.43 µM 0.459332449958765 0.323013834261154 no 1098 0.322997724248745 1646 2834131
SGTC_2572 astragaloside iv 100 µM 0.457671771783712 0.323600274531466 no 1099 0.323594135602773 1554 45006101 An anti-inflammatory agent.
SGTC_2402 5553605 200 µM 0.457662271435683 0.323603630680266 no 1100 0.32359754883718 1617 6758546
SGTC_1518 st038567 90.8 µM 0.455679036799114 0.324304553577749 no 1101 0.324310399350347 1526 77966
SGTC_1009 4106-0057 9.87 µM 0.455538740728694 0.324354161213465 no 1102 0.324360851568576 1546 2928005
SGTC_3302 9125395 16.351 µM 0.455301642648832 0.324438004397927 no 1103 0.32444612232674 1576 17599668
SGTC_2118 5526350 200 µM 0.454065291646099 0.324875349897249 no 1104 0.32489091686738 1584 743594
SGTC_722 3534-0461 190 µM 0.4534766713915 0.325083652695093 no 1105 0.325102769022566 1530 658262
SGTC_2799 7812892 81.82 µM 0.453354444145118 0.325126913718155 no 1106 0.325146767305971 1641 20205235
SGTC_1020 4335-0961 93.3 µM 0.453184086906584 0.32518721376832 no 1107 0.325208095065504 1477 669075
SGTC_1954 st077032 68.9 µM 0.452786515118561 0.325327957023921 no 1108 0.325351237350663 1462 698907
SGTC_2512 diallyl trisulfide 49.23 µM 0.452568469649924 0.325405157260423 no 1109 0.325429753680137 1516 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1868 st057644 42.7 µM 0.451286832755433 0.32585907943159 no 1110 0.32589141681283 1527 688665
SGTC_352 k048-0007 5.11 µM 0.45058837897644 0.326106562205085 no 1111 0.326143121894948 1536 6811911
SGTC_2874 9043904 71.43 µM 0.450270358753007 0.326219271538378 no 1112 0.326257754598139 1541 4463428
SGTC_2735 sertaconazole 140 nM 0.450181629992753 0.326250720671279 no 1113 0.326289740454685 1617 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_596 1155-0152 116 µM 0.448166916866357 0.326965150272602 no 1114 0.327016368460757 1536 280313
SGTC_1753 st043925 64 µM 0.447206289892879 0.327306018098022 no 1115 0.327363060176319 1606 670181
SGTC_2254 7938975 95.19 µM 0.446911921016127 0.327410500477472 no 1116 0.327469328176374 1663 2969277
SGTC_2553 4-methylesculetin 85.09 µM 0.446493117873018 0.32755917247185 no 1117 0.327620541393459 1508 5319502
SGTC_3201 9113999 49.47 µM 0.445137340897349 0.32804065066066 no 1118 0.328110252568589 1642 16649224
SGTC_2385 9074692 200 µM 0.443843302973515 0.328500470107063 no 1119 0.328577939148132 1517 17046906
SGTC_2279 7948423 32.93 µM 0.443275668353014 0.328702253678863 no 1120 0.328783176451141 1718 1247112
SGTC_1745 st081495 74 µM 0.442784292670061 0.328876968954084 no 1121 0.328960882833414 1596 13842402 YBL026W LSM2
SGTC_2950 9072895 21.46 µM 0.440621076889416 0.329646573920035 no 1122 0.329743670797434 1497 17332245
SGTC_481 bay k-8644 50 µM 0.439795062850011 0.329940634702087 no 1123 0.330042771896953 1511 2303 A calcium channel antagonist.
SGTC_738 1315-0003 72.4 µM 0.439765881351608 0.329951025231328 no 1124 0.330053340555993 1645 6251474
SGTC_899 1083-0020 478 µM 0.439681582317053 0.329981041958882 no 1125 0.330083871886888 1657 767123
SGTC_2319 6033012 152.6 µM 0.439391467370773 0.330084352827482 no 1126 0.330188954044386 1489 847246
SGTC_2035 5154463 94.595 µM 0.43898256508441 0.330229986253023 no 1127 0.330337084754792 1642 2769623
SGTC_192 3455-0609 60.9 µM 0.438846246966411 0.330278542627807 no 1128 0.330386473856937 1582 3769639
SGTC_272 doxorubicin 8.13 µM 0.434006454935595 0.332004318489983 no 1129 0.33214187683514 1571 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_424 splitomicin 100 mM 0.433822380269612 0.332070026636988 no 1130 0.332208714186304 1534 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2969 9091408 28.7 µM 0.431696171213413 0.332829381968654 no 1131 0.332981125274157 1501 4286311
SGTC_53 0973-0023 39.979 µM 0.431634892027856 0.332851277434592 no 1132 0.333003397359943 1678 674768
SGTC_1274 0865-0114 173 µM 0.429283659629998 0.33369181852338 no 1133 0.333858403439372 1599 870624
SGTC_2618 avocadyne 43.43 µM 0.428684124088741 0.333906280063067 no 1134 0.334076557851022 1649 3015189
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.427453103949662 0.334346801756667 no 1135 0.334524667758741 1614 66535 A nucleotide analog.
SGTC_1813 st051246 8.6015 µM 0.426343741923719 0.334743983521403 no 1136 0.334928694339914 1677 5291959
SGTC_2723 salbutamol 83.58 µM 0.424591632475208 0.335371662963221 no 1137 0.335567196926033 1624 9884233 β2-adrenoceptor agonist
SGTC_1547 harmine 94.2 µM 0.423767564632201 0.33566703789984 no 1138 0.335867667593847 1596 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2014 4013930 200 µM 0.423640344474106 0.335712647139667 no 1139 0.335914063817059 1581 64556
SGTC_634 1611-4317 11.2 µM 0.423168839206188 0.335881705894374 no 1140 0.336086040002363 1646 2843522
SGTC_1965 Pectolinarigenin 58.4 µM 0.420641321353547 0.336788515816834 no 1141 0.337008507658167 1570 5320438 An anti-inflammatory.
SGTC_68 0986-0284 82.829 µM 0.420307427120586 0.336908379806417 no 1142 0.337130442447519 1517 423278 YIL048W NEO1
SGTC_2116 5511452 16.8835 µM 0.4195713608372 0.337172677190968 no 1143 0.337399306823652 1620 870744
SGTC_2851 9015922 71.43 µM 0.417858327806262 0.337788082506462 no 1144 0.338025351092858 1672 2996893
SGTC_1604 st002052 72.4 µM 0.417838007065309 0.337795385318609 no 1145 0.338032780194988 1619 6254834 YHR062C RPP1
SGTC_2293 7624732 200 µM 0.417743218069954 0.337829451134494 no 1146 0.338067435135136 1518 894453
SGTC_1245 0418-0076 17.2 µM 0.415990856108773 0.338459464116201 no 1147 0.338708347125378 1634 6790114
SGTC_1320 1313-0481 95.3 µM 0.415323476450518 0.33869952096147 no 1148 0.338952558734089 1702 6813365 YLR208W SEC13
SGTC_2968 9090663 33.37 µM 0.415127345604758 0.338770081804173 no 1149 0.339024340997038 1613 25236811
SGTC_1284 0929-0043 16 µM 0.41437356864172 0.339041316360251 no 1150 0.339300271489643 1588 1239883
SGTC_31 0508-1974 57.237 µM 0.413141468548294 0.339484847467842 no 1151 0.339751484329871 1651 6810525
SGTC_2138 5575593 77.673 µM 0.411642253729455 0.340024834424531 no 1152 0.340300828232279 1569 762213
SGTC_3275 9138069 49.47 µM 0.411157008621613 0.340199680319184 no 1153 0.340478704960208 1641 17617007
SGTC_3338 9144300 39.5675 µM 0.411103464516203 0.340218975699508 no 1154 0.34049833484512 1665 4901274
SGTC_1897 st060201 15 µM 0.410068985891992 0.340591846869498 no 1155 0.340877671370024 1562 611878
SGTC_2358 9037157 4 µM 0.406858451525926 0.341750054357124 no 1156 0.342055976642869 1655 2388925
SGTC_1058 3448-5425 97.3 µM 0.40528540305148 0.342318080176152 no 1157 0.342633867426272 1596 7279705
SGTC_1063 disulfiram 1.84 µM 0.404355907793102 0.342653887583586 no 1158 0.342975509377035 1618 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2561 acetosyringone 100 µM 0.40217442136731 0.343442501644623 no 1159 0.343777832701549 1599 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2728 chlorpromazine 9.18 µM 0.402037682402118 0.343491955952158 no 1160 0.343828147064013 1647 2726 A thorazine and dopamine antagonist.
SGTC_89 0302-0250 142.109 µM 0.400782955825759 0.343945877233532 no 1161 0.344289964313991 1681 4203518 YLR208W SEC13
SGTC_447 ml7 120 µM 0.400457215706521 0.344063756753167 no 1162 0.344409894899308 1697 4216 Selective myosin light chain kinase inhibitor.
SGTC_2683 piperine 63.03 µM 0.399343619516898 0.344466861695785 no 1163 0.344820015440455 1622 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2173 5763948 167 µM 0.397104484177123 0.34527792926463 no 1164 0.34564520667142 1636 2867177
SGTC_2998 9066762 71.4286 µM 0.397057055259511 0.345295116839388 no 1165 0.345662693658638 1721 4945196
SGTC_1404 3909-7820 48.3 µM 0.393788255305694 0.346480451156572 no 1166 0.346868688093792 1722 23741373
SGTC_2767 sibutramine 71.45 µM 0.392799021222781 0.346839465009867 no 1167 0.347233963818828 1754 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2165 5727197 32.143 µM 0.390653547376721 0.347618574929263 no 1168 0.348026669714875 1696 1361712
SGTC_2659 sanguinarine 24.21 µM 0.390437080950668 0.347697218627579 no 1169 0.348106686314094 1642 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2777 climbazole 1.536 µM 0.389858435280411 0.347907476633737 no 1170 0.348320615304658 1664 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1113 artemisinin 1.17947 µM 0.389428135568854 0.348063861644557 no 1171 0.348479731143769 1762 2240 An anti-malaria and mitochondrial poison.
SGTC_1548 st061468 90.8 µM 0.388187596145483 0.348514858877646 no 1172 0.348938605857031 1718 390799
SGTC_2727 riluzole 51.77 µM 0.386740267575256 0.349041304891827 no 1173 0.349474251063774 1655 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2896 9052656 71.43 µM 0.386520984878234 0.349121091360608 no 1174 0.349555432093506 1639 6469436
SGTC_524 r073-0010 27.8 µM 0.385808435786339 0.349380399874081 no 1175 0.349819273626132 1607 2772106
SGTC_1173 0443-0020 122 µM 0.383588603104202 0.35018868432876 no 1176 0.350641694207236 1629 5331295
SGTC_1833 st055984 71 µM 0.383498038989605 0.350221674934537 no 1177 0.350675261990495 1665 676288
SGTC_762 1165-0429 115 µM 0.38276894612457 0.350487309316787 no 1178 0.350945544278 1762 5967793
SGTC_1902 st060212 70.5 µM 0.381658283949381 0.350892103455569 no 1179 0.351357423217419 1626 688944
SGTC_1072 oxiconazole 14.9 nM 0.381518250455955 0.350943152367792 no 1180 0.351409365767205 1664 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_246 cycloheximide 667 µM 0.381225624603363 0.35104983718488 no 1181 0.351517918277936 1630 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2315 7733312 200 µM 0.378193648876236 0.35215591718385 no 1182 0.35264337158831 1616 726316
SGTC_1790 st045711 43.5 µM 0.377742137049509 0.352320738289173 no 1183 0.352811081062529 1780 585119
SGTC_1596 piperlongumine 63 µM 0.377563926239743 0.352385800484566 no 1184 0.35287728352989 1767 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2889 9059656 51.95 µM 0.377507316189979 0.352406468901084 no 1185 0.352898314190903 1717 3949838
SGTC_2595 hexamethylquercetagetin 100 µM 0.376424334963429 0.352801950876167 no 1186 0.353300728718384 1665 386331
SGTC_1771 st048882 4.1505 µM 0.376423392897686 0.352802294968095 no 1187 0.353301078842976 1587 4580403
SGTC_1734 st037168 69.4 µM 0.376035818801429 0.352943867612029 no 1188 0.353445133695871 1639 708907
SGTC_587 k089-0003 57 µM 0.375785408163197 0.353035348166367 no 1189 0.353538218336464 1723 9659696
SGTC_1460 k062-0059 9.15 µM 0.374869795399481 0.353369914079642 no 1190 0.353878651753135 1608 1373085
SGTC_628 1636-0253 16 µM 0.374835953746279 0.353382282030532 no 1191 0.353891236638441 1752 4456143
SGTC_2881 9058953 51.95 µM 0.374756876887789 0.353411182484116 no 1192 0.35392064401546 1585 17122249
SGTC_1229 0139-0193 12.2 µM 0.373702045580988 0.35379677558057 no 1193 0.354313001634141 1779 3090752
SGTC_2544 sphondin 68.51 µM 0.372860699435903 0.354104436854782 no 1194 0.354626061711533 1745 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2643 anethole 100 µM 0.372813226601699 0.354121799438754 no 1195 0.354643729010276 1673 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_589 1227-0070 34.1 µM 0.372740570579303 0.35414837304008 no 1196 0.354670768988373 1695 2841384
SGTC_1976 st070609 63.5 µM 0.372379534484327 0.354280430839778 no 1197 0.354805144593906 1647 682556
SGTC_1653 st012112 65 µM 0.371656531060312 0.354544939732635 no 1198 0.355074296707457 1720 720429
SGTC_877 0771-0151 33.1 µM 0.369581923038484 0.355304318712976 no 1199 0.355847011111572 1703 6166523
SGTC_2959 9079155 11 µM 0.368983526013979 0.355523459880615 no 1200 0.356070002029271 1702 16189457
SGTC_2183 6420625 130.508 µM 0.367865652063832 0.355932968523587 no 1201 0.356486706382132 1637 2897619
SGTC_3050 9093513 49.47 µM 0.366582073841081 0.356403384358214 no 1202 0.356965390858898 1656 25236664
SGTC_2223 6903751 107.57 µM 0.366119277286242 0.356573047325153 no 1203 0.357138036746011 1746 5598863
SGTC_2725 haloperidol 53.21 µM 0.365870352802419 0.356664315724098 no 1204 0.357230909928637 1663 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2283 7944793 200 µM 0.363986307546463 0.357355368518564 no 1205 0.35793411704871 1610 2970533
SGTC_1437 4092-1038 11.6 µM 0.361880764770028 0.358128218644588 no 1206 0.358720567321452 1677 3977136
SGTC_2304 7443016 91.4 µM 0.360127584798405 0.35877217622849 no 1207 0.359375862568478 1659 939854
SGTC_2285 7945142 200 µM 0.359145320286105 0.359133145834962 no 1208 0.359743189721344 1676 2970608
SGTC_1466 k213-0079 57.5 µM 0.358817078014218 0.359253798716729 no 1209 0.359865967946663 1686 3657981
SGTC_1299 1079-1439 3.74 µM 0.358793159080786 0.359262591211322 no 1210 0.359874915331113 1643 323161
SGTC_228 caffeine 993.056 µM 0.357939371783074 0.359576488442776 no 1211 0.360194342836246 1762 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1365 1672-3266 55.4 µM 0.354876809287879 0.360703226226285 no 1212 0.361340941348991 1789 6415873
SGTC_487 nimodipine 119 µM 0.354727210075348 0.360758295886457 no 1213 0.361396982095066 1779 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2954 9074818 52.69 µM 0.354181990279605 0.360959023704696 no 1214 0.36160124980405 1752 16648742
SGTC_482 fipronil 114 µM 0.354078387953765 0.360997170211675 no 1215 0.361640069088721 1737 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1688 st021091 57.6 µM 0.353556555262084 0.361189330680245 no 1216 0.361835618888585 1815 3656366
SGTC_2569 tetrandrine 100 µM 0.352958085603949 0.361409755188376 no 1217 0.362059931779966 1624 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2273 7815444 169.05 µM 0.352722698327617 0.361496464132386 no 1218 0.362148170461744 1817 2824616
SGTC_2072 5231554 129 µM 0.352329283991729 0.361641400935366 no 1219 0.362295664465169 1856 789545
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.350247820044239 0.362408557854214 no 1220 0.363076360778771 1740 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3143 9086658 49.47 µM 0.346395646006424 0.363829794803268 no 1221 0.364522698399889 1691 25236626
SGTC_985 1493-0307 8.71 µM 0.34584726929077 0.364032268112652 no 1222 0.364728749441342 1835 3278274
SGTC_2713 st079149 53.4 µM 0.344576962946027 0.3645014402044 no 1223 0.365206213588068 1723 3103253
SGTC_2417 cerulenin 830 nM 0.343501343878962 0.364898865732635 no 1224 0.365610664998161 1703 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2303 7774051 200 µM 0.342950324399427 0.365102515649463 no 1225 0.365817915793297 1802 2953184
SGTC_1953 st076800 12.1 µM 0.342575871327946 0.365240930547306 no 1226 0.365958778355141 1655 297591
SGTC_197 4544-0043 41.561 µM 0.340788290096931 0.365901943607481 no 1227 0.366631483252068 1714 896523
SGTC_3103 9120822 49.47 µM 0.339497308610978 0.366379571468215 no 1228 0.367117562121394 1824 17141819
SGTC_1489 4065-0444 182 µM 0.339058457575109 0.366541981548408 no 1229 0.367282846376218 1839 2877968
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.338725933618222 0.366665057999552 no 1230 0.36740810109459 1679 803109
SGTC_2916 7875993 68.79 µM 0.338316630993555 0.3668165712148 no 1231 0.367562296077967 1880 1299250
SGTC_744 1594-0068 283 µM 0.337434398667188 0.367143221281107 no 1232 0.367894728612619 1707 668392
SGTC_318 1488-0629 67.2 µM 0.336688386329714 0.367419510419543 no 1233 0.368175909557292 1693 3662576
SGTC_2206 7254556 146.969 µM 0.336347976646462 0.367545605546609 no 1234 0.368304237502874 1795 4398905
SGTC_57 miconazole 162.5 nM 0.334741112238687 0.368141015570707 no 1235 0.368910192842795 1661 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2464 5717415 7.67 µM 0.333551830143599 0.368581898145459 no 1236 0.369358886153614 1646 5285744
SGTC_2362 9071156 126 µM 0.332899918561543 0.368823643843116 no 1237 0.369604915457856 1783 653133
SGTC_984 1492-0255 2.91 µM 0.330854754554803 0.369582380102555 no 1238 0.370377099789133 1757 1585198
SGTC_453 enantio-paf c16 10 µM 0.330579499502793 0.369684535951778 no 1239 0.370481066700088 1728 13871343 A lipid and platelet activating factor
SGTC_2131 toluylene red 5.2905 µM 0.330474649030754 0.369723451695476 no 1240 0.370520672384446 1667 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2762 leflunomide 42.06 µM 0.330446147848061 0.369734030273574 no 1241 0.37053143851357 1742 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2925 9010536 32.5 µM 0.330323685816034 0.36977948474317 no 1242 0.370577698872184 1802 2994177
SGTC_1740 st038286 13.222 µM 0.328952635877131 0.370288504089893 no 1243 0.371095744251098 1768 716786
SGTC_1910 st062352 60.4 µM 0.327576920847002 0.370799483818648 no 1244 0.371615787204534 1650 2245730
SGTC_828 2074-0507 139 µM 0.326350999123553 0.371255018157798 no 1245 0.372079403361828 1837 X828
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.325203938389647 0.371681412330588 no 1246 0.372513364073616 1728 61125 An anti-inflammatory.
SGTC_1051 3253-3903 78 µM 0.325133062357314 0.371707764081367 no 1247 0.372540183500731 1719 5509239
SGTC_520 3584-0023 682 µM 0.322034453395331 0.372860414764407 no 1248 0.37371329682225 1700 1340790
SGTC_236 1509-0011 5.31 µM 0.321973868706197 0.372882963034001 no 1249 0.373736245500296 1832 3107280
SGTC_986 1493-0483 84 µM 0.321908524320387 0.372907283244683 no 1250 0.373760997590211 1845 40079
SGTC_1324 1418-0026 34.4 µM 0.321325440395608 0.373124320844477 no 1251 0.3739818895786 1781 1372513
SGTC_1045 1348-1485 165 µM 0.320817357020134 0.373313474304487 no 1252 0.37417440256142 1745 6810614
SGTC_3333 9141820 12.094 µM 0.320574835345605 0.373403773037465 no 1253 0.374266305183186 1715 1939433
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.320467896640212 0.373443592015837 no 1254 0.374306831449582 1736 6708784 An antioxidant flavonoid
SGTC_627 1391-0720 175 µM 0.320230084044142 0.373532147160931 no 1255 0.37439695961152 1753 997839
SGTC_1675 st018485 24.5 µM 0.319760150761072 0.373707157568003 no 1256 0.374575078947884 1739 3323024
SGTC_1907 st060210 83.7 µM 0.318795101870639 0.374066638293782 no 1257 0.374940946392394 1838 688793
SGTC_2593 nobiletin 86.24 µM 0.318385288995062 0.374219326750396 no 1258 0.375096347918545 1688 72344 An anti-infammatory.
SGTC_1857 st056007 79.3 µM 0.318157129481128 0.374304343183762 no 1259 0.375182875064466 1857 619834
SGTC_894 0960-0238 55.9 µM 0.317970810668635 0.374373773535931 no 1260 0.375253539214528 1833 6741907 YDL195W SEC31
SGTC_666 0272-0154 136 µM 0.317843453737135 0.374421234515744 no 1261 0.375301843613016 1779 6870312
SGTC_229 benomyl 22.8748 µM 0.317499381276362 0.374549466465712 no 1262 0.375432354438156 1738 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_927 2425-1185 123 µM 0.317153238915017 0.374678483845643 no 1263 0.375563664788531 1693 730375
SGTC_1065 prochlorperazine maleate 2.48 µM 0.316524109912041 0.374913014536029 no 1264 0.375802364042274 1749 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_357 1325-0123 420 µM 0.316439738985504 0.374944470384013 no 1265 0.375834379022721 1871 1098503
SGTC_1081 sertraline 6 µM 0.31589812127159 0.375146420462918 no 1266 0.376039918986773 1851 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2931 9014674 55.67 µM 0.315851048909222 0.375163973698598 no 1267 0.376057784266203 1692 2996810
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.314018541790282 0.375847514326157 no 1268 0.376753478118844 1825 688761
SGTC_1114 scopoletin 1.73284 µM 0.312630653052841 0.376365468063826 no 1269 0.377280643449762 1872 5280460 A coumarin with genotoxic properties.
SGTC_1143 3454-2408 5.08 µM 0.311494491480142 0.376789644209146 no 1270 0.377712364953204 1772 X1143
SGTC_2372 9071633 200 µM 0.309992190038402 0.377350743876121 no 1271 0.378283447734805 1866 21321366
SGTC_913 3487-1245 167 µM 0.309619866496983 0.377489844355766 no 1272 0.378425023467212 1669 4016153
SGTC_3141 9094609 49.47 µM 0.309409869418163 0.377568306503645 no 1273 0.378504881890551 1691 25236309 YDL196W YDL196W
SGTC_1192 1488-0095 21.4 µM 0.30894725911393 0.37774117148278 no 1274 0.378680823256337 1774 915875
SGTC_395 anisomycin 6.25 µM 0.308743207693633 0.377817427773718 no 1275 0.378758436711116 1767 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3294 9122953 26.2835 µM 0.307497638603916 0.378283013975526 no 1276 0.379232310072225 1714 16459826
SGTC_479 n-linoleoylglycine 10 µM 0.306883235984254 0.37851273911577 no 1277 0.379466124770928 1751 6433346 An anti-infammatory.
SGTC_1479 0549-0158 134 µM 0.302399137057224 0.380190639235579 no 1278 0.381173906250264 1762 5440202
SGTC_2413 inermin 26.06 µM 0.302330458240826 0.380216355717795 no 1279 0.381200080864886 1911 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1135 dihydrocapsaicin 536.708 nM 0.301404881877521 0.380562985348885 no 1280 0.381552886052509 1655 107982 A Capsaicinoid.
SGTC_2844 9010103 25.97 µM 0.300978038322275 0.380722871183419 no 1281 0.381715620688971 1779 2480525
SGTC_279 1273-0055 2.93 µM 0.29895050819776 0.381482615389625 no 1282 0.382488904140938 1904 2847562
SGTC_1783 st039459 87.517 µM 0.298914922402453 0.381495953978591 no 1283 0.382502480468187 1912 729761
SGTC_2499 avocadenofuran 51.48 µM 0.298775587964825 0.381548181924268 no 1284 0.38255563930178 1705 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2069 5228469 200 µM 0.298257317506012 0.381742468696794 no 1285 0.382753389112126 1757 2835210
SGTC_3285 9112818 20.8695 µM 0.297469097423992 0.382038010003795 no 1286 0.383054198722453 1786 17017947 YPR165W RHO1
SGTC_1 0258-0098 57.368 µM 0.296967096317311 0.382226270012529 no 1287 0.383245814935826 1789 6790032 YDR047W HEM12
SGTC_2188 6126565 140.678 µM 0.295882343055377 0.382633168258121 no 1288 0.383659967925821 1871 874518
SGTC_2587 piperic acid 92.2 µM 0.295561554164135 0.382753523178216 no 1289 0.383782468899032 1749 5370536
SGTC_2241 6772625 37.8075 µM 0.295515020927928 0.382770982653365 no 1290 0.383800239702241 1731 2285411
SGTC_615 k087-0205 167 µM 0.294931769544445 0.38298984133631 no 1291 0.384023001117107 1730 9642773
SGTC_979 1426-2828 121 µM 0.292540643774316 0.383887474886981 no 1292 0.384936644512511 1865 747872
SGTC_263 alizarin 107.927 µM 0.291736614159981 0.384189449543785 no 1293 0.385244006158773 1817 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2231 micatex 6.853 µM 0.291581793419943 0.384247604659525 no 1294 0.385303198777595 1834 20737 An antifungal of unknown mechanism.
SGTC_532 1548-0774 215 µM 0.291079229618796 0.384436400007081 no 1295 0.385495362421885 1909 5932993
SGTC_1996 st072960 66.8 µM 0.289997966855119 0.384842684867346 no 1296 0.385908896508893 1926 1719405
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.289152177006179 0.385160578888048 no 1297 0.386232463282187 1754 5282362
SGTC_1798 st045719 60.953 µM 0.288435756098841 0.385429909388851 no 1298 0.386506600375902 1886 3980186
SGTC_610 4215-0184 155 µM 0.287196783873405 0.38589581762308 no 1299 0.386980824369286 1819 5605015
SGTC_683 panaxydol 45 µM 0.286702104728877 0.386081884840376 no 1300 0.387170212938285 1891 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2601 securinine 100 µM 0.28409604115202 0.387062553990702 no 1301 0.388168390367377 1757 442872 A GABA receptor antagonist.
SGTC_618 k072-0232 33.2 µM 0.282366269264749 0.387713870789847 no 1302 0.388831338151571 1819 5872756 YGL099W LSG1
SGTC_1121 fusaric acid 630.51 nM 0.281772636139188 0.387937466401722 no 1303 0.389058927149145 1750 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1071 trifluoperazine 6.31 µM 0.280004508806561 0.388603662463664 no 1304 0.389737022838728 1874 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_838 0109-0203 71.4 µM 0.27991559906836 0.388637170599187 no 1305 0.389771129555176 1815 759422
SGTC_1360 1598-0022 39.8 µM 0.279610210237684 0.388752271279242 no 1306 0.389888286405862 1886 761525
SGTC_2855 9016525 58.44 µM 0.279490877724225 0.388797250213282 no 1307 0.389934068865489 1806 43811474
SGTC_70 0141-0289 43.283 µM 0.279223320260792 0.388898103665651 no 1308 0.390036724048012 1866 352408
SGTC_874 0599-0792 117 µM 0.277786476953948 0.38943983713175 no 1309 0.390588136310101 1973 765305
SGTC_1553 gossypol 38.6 µM 0.277512934683183 0.389542995242181 no 1310 0.390693137633005 1854 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2350 9023895 38.85 µM 0.276590081411868 0.389891078543216 no 1311 0.39104744078829 1868 2997209
SGTC_2147 5545932 89.7195 µM 0.274852597323797 0.390546665100574 no 1312 0.391714743405195 1831 797404
SGTC_2453 5731132 22.18 µM 0.273420637640605 0.391087205449573 no 1313 0.392264945215188 1950 1362040
SGTC_2765 myclobutanil 7.74 µM 0.273064275978453 0.391221758641977 no 1314 0.39240190356476 1823 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_580 1123-0028 41 µM 0.272642335565494 0.391381089552601 no 1315 0.392564082635427 1870 1677248 YPR107C YTH1
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.272260228909665 0.391525394378106 no 1316 0.39271096710903 1826 5106787 A p450 inhibitor.
SGTC_2522 biochanin a 4.94 µM 0.271277664461205 0.391896534127787 no 1317 0.393088741885024 1881 5280373 A possible chelator.
SGTC_200 k038-0079 37.545 µM 0.267968959039399 0.393147038575232 no 1318 0.394361606140512 1863 3436683
SGTC_582 0987-0078 156 µM 0.266734485171984 0.393613883547898 no 1319 0.394836800109376 1913 1625765
SGTC_2782 7736369 71.43 µM 0.266043285400118 0.393875343646213 no 1320 0.395102936471405 1792 2950836 YOL077C BRX1
SGTC_1044 1222-0021 1.78 µM 0.265818143598031 0.393960518358869 no 1321 0.395189634602501 1876 4306703
SGTC_2031 5180455 200 µM 0.265503189950396 0.394079678826837 no 1322 0.395310926394371 1824 29949
SGTC_897 1000-0139 31.4 µM 0.2620079248551 0.395402750717424 no 1323 0.396657666207918 1964 6151020
SGTC_920 mycophenolic acid 780.421 nM 0.261977544139707 0.395414256120629 no 1324 0.396669377452028 1802 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_348 k064-0012 10.7 µM 0.260635613236585 0.395922546152955 no 1325 0.39718676161534 1798 5066323
SGTC_204 PMA1.184 62.41 µM 0.260625768325875 0.395926275815304 no 1326 0.397190558010334 1861 2252213 YGL008C PMA1
SGTC_1011 4112-3381 17.4 µM 0.260407857294098 0.396008832031928 no 1327 0.397274591367442 1885 2877139
SGTC_3127 9126946 49.47 µM 0.259641750895382 0.396299110631674 no 1328 0.397570063952102 1768 27243249
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.259604783826581 0.396313118952226 no 1329 0.39758432293134 1909 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_107 0358-0022 2.6945 µM 0.259287550663474 0.396433336956063 no 1330 0.397706692086727 1940 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_729 4092-0585 94.1 µM 0.258425638990823 0.396760014859445 no 1331 0.398039215697382 1785 2169061
SGTC_2657 nystatin 74.44 µM 0.258064330348158 0.396896978013973 no 1332 0.398178629817397 1905 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_165 k038-0023 64.381 µM 0.257792353752486 0.397000085994465 no 1333 0.398283582957559 1813 46368543
SGTC_402 epigallocatechin gallate 10 µM 0.257646137957185 0.397055520267565 no 1334 0.398340009262058 1821 65064 An antioxidant.
SGTC_138 0850-0259 40.9225 µM 0.257449427086362 0.397130101839837 no 1335 0.398415925532254 1933 6813004
SGTC_244 nsc-207895 1.295 µM 0.256647401602517 0.397434223190267 no 1336 0.398725489539978 1817 42640
SGTC_1182 1222-0449 220 µM 0.256613909598296 0.397446924435614 no 1337 0.398738418096523 1879 658318
SGTC_2274 7947094 46.08 µM 0.255403727121726 0.397905937406275 no 1338 0.399205646201795 1949 2971028
SGTC_878 0828-0289 13.7 µM 0.255335093316314 0.397931973926085 no 1339 0.399232148723904 1819 745350 YLR208W SEC13
SGTC_109 0132-0036 33.701 µM 0.25423637243235 0.398348840076747 no 1340 0.399656476190634 1971 67274 A color developer.
SGTC_2437 5741531 144.16 µM 0.251800449814584 0.399273467653921 no 1341 0.400597654809229 1979 2262990
SGTC_2428 5615643 7.78 µM 0.251720122614334 0.399303967912046 no 1342 0.400628701062769 1896 2253075
SGTC_3317 9138495 8.753 µM 0.251047784027201 0.399559279128443 no 1343 0.400888582772961 1876 17020139
SGTC_2189 6047310 154.431 µM 0.250625151599187 0.399719789902957 no 1344 0.401051967029701 1856 711535
SGTC_604 1000-0114 314 µM 0.249957012822395 0.399973575636567 no 1345 0.401310296177398 1974 1572745
SGTC_3309 9129340 25.759 µM 0.245389488208712 0.401709629946042 no 1346 0.403077433719206 1911 17158987
SGTC_787 4152-0075 138 µM 0.243567296938222 0.402402763920265 no 1347 0.403782979418623 1876 9566539
SGTC_1507 4075-3230 155 µM 0.242704740814276 0.402730974388875 no 1348 0.404117067305866 2004 659771
SGTC_3094 9117742 49.47 µM 0.242277688959343 0.402893496902952 no 1349 0.404282500244981 1947 17149698
SGTC_58 0957-0393 9 µM 0.241133992710213 0.403328834319509 no 1350 0.404725633789237 1858 6997992
SGTC_311 1315-0136 58 µM 0.238693332975432 0.404258248975648 no 1351 0.405671693432507 1978 6759207
SGTC_571 k831-0106 44.2 µM 0.237707284027444 0.404633894662144 no 1352 0.406054066875856 2016 4783639
SGTC_2594 a-mangostin 100 µM 0.2376111794819 0.404670511403956 no 1353 0.406091339425686 1988 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_3038 9091290 49.47 µM 0.236676627085952 0.405026628201472 no 1354 0.406453834363944 1971 25236843
SGTC_1237 0330-0133 46.1 µM 0.234004190560154 0.406045409301929 no 1355 0.407490862690195 1875 X1237 YHR072W ERG7
SGTC_2779 methotrexate 400 µM 0.233931254417653 0.406073222832123 no 1356 0.407519174395016 2005 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2795 7780010 54.55 µM 0.233858231612295 0.406101069885301 no 1357 0.407547520223777 1906 953673
SGTC_2334 9017922 200 µM 0.232135653716032 0.406758107878829 no 1358 0.408216326727965 1979 3163164
SGTC_2893 9048488 25.97 µM 0.23196534244416 0.406823083515874 no 1359 0.408282466186617 1810 6467338
SGTC_1389 3405-0187 19 µM 0.230646186096093 0.407326443020174 no 1360 0.408794841761526 1836 799890
SGTC_2804 7954240 19.48 µM 0.23008982735439 0.407538782570215 no 1361 0.409010984723642 1986 828705
SGTC_2900 5328528 85.29 µM 0.228876990363704 0.408001767311858 no 1362 0.409482262465607 1891 795359
SGTC_2056 5235370 200 µM 0.226177975042053 0.409032541517255 no 1363 0.410531500072846 1865 5511916
SGTC_117 lucigenin 22.078 µM 0.22499903439874 0.409482985725168 no 1364 0.410990012721994 1790 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_98 0074-0023 107.663 µM 0.224857396029713 0.409537110314316 no 1365 0.411045106799674 1846 3563821
SGTC_3259 9138485 49.47 µM 0.224075772236831 0.409835824960039 no 1366 0.411349172063026 1999 17646153
SGTC_2320 7373003 200 µM 0.223528484321769 0.410045014183998 no 1367 0.411562108302461 1840 5415828
SGTC_1408 3909-7976 48.8 µM 0.223436921275922 0.410080014722297 no 1368 0.411597735772404 1938 24152374
SGTC_528 3492-0019 172 µM 0.223266893539719 0.410145010771897 no 1369 0.411663896034103 1994 2869262
SGTC_500 h-89 112 µM 0.222979270577075 0.41025496525433 no 1370 0.411775820023365 2030 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2146 5545642 200 µM 0.222367307603753 0.410488934130305 no 1371 0.412013979741859 2001 825326
SGTC_1193 1488-0126 41.5 µM 0.220682116670022 0.411133389541128 no 1372 0.412669978506245 1892 1384710
SGTC_1041 0206-0046 107 µM 0.220503279679485 0.411201794991931 no 1373 0.412739609210269 1907 50494
SGTC_630 4356-0227 183 µM 0.217979295924905 0.412167510051649 no 1374 0.413722621507767 1960 779312
SGTC_2627 acetyl isogambogic acid 100 µM 0.217807299047756 0.412233338136873 no 1375 0.413789628638435 1848 6857789 A caspase activator and apoptosis inducer.
SGTC_3272 9137413 49.47 µM 0.21714984993792 0.412484985309862 no 1376 0.414045783027766 1981 17614870
SGTC_953 1188-0045 9.7 µM 0.216999909644888 0.412542381943688 no 1377 0.414104207677344 1955 6144426
SGTC_2441 5730946 39.09 µM 0.215465621738649 0.413129809404193 no 1378 0.414702156229144 1983 1774275
SGTC_3043 9092303 49.47 µM 0.215170304195749 0.413242898969101 no 1379 0.414817271242506 1854 25236084
SGTC_2597 laccaic acid a 100 µM 0.214144756073051 0.413635680525461 no 1380 0.415217087465839 1908 5491415 A textile dye.
SGTC_714 4296-0578 26.1 µM 0.214051728436428 0.413671314085719 no 1381 0.415253359210522 2046 1589775
SGTC_1137 ixabepilone 100 µM 0.21361365688296 0.413839123762813 no 1382 0.415424174280649 1844 154225 A novel microtubule stabilizer.
SGTC_1763 st044482 94.5 µM 0.213423227564237 0.413912075390227 no 1383 0.415498432427841 1976 88505
SGTC_304 1310-0298 97 µM 0.212682490146653 0.414195872952019 no 1384 0.415787312574571 1936 1550234
SGTC_1682 st012968 530 nM 0.210842606171871 0.414900978374199 no 1385 0.416505045432107 1845 24207270
SGTC_2493 resveratrol 26.09 µM 0.208989884589725 0.415611280722793 no 1386 0.417228067596293 1919 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_458 nppb 133 µM 0.208332726010301 0.415863290677888 no 1387 0.417484590265009 2064 4549 A chloride channel blocker.
SGTC_2996 9066192 71.4286 µM 0.207892983276924 0.416031944414756 no 1388 0.417656264008951 1860 6472854
SGTC_2817 7995342 71.43 µM 0.207638616487938 0.416129508312042 no 1389 0.417755574918238 1890 18879975
SGTC_1715 st032160 10.2275 µM 0.207545746079747 0.416165130598698 no 1390 0.417791835065648 2015 5289825
SGTC_3146 9095609 49.47 µM 0.205549196081753 0.416931113022884 no 1391 0.418571532818228 1976 17173999
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.204940215902708 0.417164813021537 no 1392 0.418809417131732 2016 17037758
SGTC_1470 k295-0292 231 µM 0.204169766641274 0.417460519732673 no 1393 0.41911041821751 2020 5045612
SGTC_76 0433-0009 400.328 µM 0.201387467545944 0.418528783595667 no 1394 0.420197806959312 1902 2841569
SGTC_1293 1000-1278 195 µM 0.20067568743261 0.418802168482297 no 1395 0.420476085799454 2010 678847
SGTC_994 3910-0338 138 µM 0.199206026891916 0.419366768691409 no 1396 0.421050792563776 2019 3479481
SGTC_944 3370-0224 231 µM 0.199199480669671 0.419369283929153 no 1397 0.421053352823543 1907 4580514
SGTC_2975 9084847 53.72 µM 0.199052956590757 0.41942558335238 no 1398 0.421110659986083 1892 27211724
SGTC_2837 9008476 45.46 µM 0.19747182486219 0.42003321144434 no 1399 0.421729163907768 1991 2992805
SGTC_3063 1327-0034 4 µM 0.196243700655851 0.420505310572201 no 1400 0.422209712410644 2030 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1256 0570-0116 285 µM 0.1956481266413 0.420734294414479 no 1401 0.42244279427077 1906 410638
SGTC_1658 st012944 20 µM 0.194313022280977 0.421247707182113 no 1402 0.42296539483014 2030 24207260
SGTC_3193 9111931 49.47 µM 0.19366547405979 0.421496769356316 no 1403 0.423218913837376 1956 17087244
SGTC_2478 5763493 32.33 µM 0.191536402839503 0.422315880788394 no 1404 0.424052681549538 2000 1365576 YLR208W SEC13
SGTC_1970 st070122 35.8 µM 0.190976793289965 0.422531233680854 no 1405 0.424271887394272 2042 102928
SGTC_2028 5153890 36.43 µM 0.190796510336804 0.422600616373071 no 1406 0.424342511405371 1963 2830968 YPR165W RHO1
SGTC_2706 st078239 82.5 µM 0.19031376037454 0.422786416650782 no 1407 0.424531635743182 2049 15434492
SGTC_1189 1431-2119 7.28 µM 0.190117872529674 0.422861814652162 no 1408 0.424608382621497 2015 3107275
SGTC_2689 tacrolimus 100 µM 0.189306709075618 0.423174064702136 no 1409 0.424926218658799 1934 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1316 1272-0050 65.9 µM 0.18772638472988 0.423782534730665 no 1410 0.425545572974613 1990 7340392
SGTC_1385 3091-4834 14.1 µM 0.187671598657289 0.423803632202296 no 1411 0.425567047814731 2025 4072814
SGTC_1308 1187-1617 41.4 µM 0.186467704776788 0.424267292591094 no 1412 0.426039001267679 1961 2882570
SGTC_2920 7982904 15.77 µM 0.184658722725676 0.424964189888996 no 1413 0.426748361899202 1962 6456808
SGTC_3242 9133940 49.47 µM 0.184448718471945 0.425045107751713 no 1414 0.426830726785876 2044 17248444
SGTC_2694 st077685 81.9 µM 0.184096177568229 0.42518095427277 no 1415 0.426969002545394 1949 2838096
SGTC_1985 st071382 65.5 µM 0.183500376526364 0.42541055774407 no 1416 0.427202711682447 2059 6123237
SGTC_329 k048-0121 21.3 µM 0.181857489166741 0.426043807036404 no 1417 0.42784728341761 1979 6832902
SGTC_2626 ethyl orsellinate 100 µM 0.18181769666286 0.42605914738993 no 1418 0.427862898036153 1977 75653 A natural product.
SGTC_3189 9110682 49.47 µM 0.176890512436587 0.427959476911563 no 1419 0.429797195541836 1958 17122418
SGTC_1078 idebenone 36.1 µM 0.176710115947558 0.428029084708459 no 1420 0.429868047275492 2025 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1670 st016595 4.04 µM 0.176186230724208 0.428231243771819 no 1421 0.430073818933495 2127 597879
SGTC_158 k038-0087 26.446 µM 0.174132547376577 0.429023909026388 no 1422 0.430880647413576 1991 X158
SGTC_1737 st035557 69.7 µM 0.173894334441632 0.429115871256466 no 1423 0.430974252627291 2055 5716916
SGTC_2846 9008642 19.48 µM 0.172875820592537 0.429509112404461 no 1424 0.431374518923224 1961 2992898
SGTC_3355 9151058 44.0485 µM 0.172063670421883 0.429822728115415 no 1425 0.431693736776671 2119 17015728
SGTC_1037 k284-1091 78.7 µM 0.172059342856398 0.429824399344523 no 1426 0.431695437857832 2068 3334711
SGTC_3110 9122132 49.47 µM 0.168481417763807 0.431206558138704 no 1427 0.433102280590528 2074 918317
SGTC_2096 5468907 200 µM 0.167825086333952 0.431460192118903 no 1428 0.433360443180742 2107 759785
SGTC_1052 3253-3998 198 µM 0.166194890353971 0.432090290248927 no 1429 0.43400179021835 2100 5450317
SGTC_280 3448-3607 3.04 µM 0.165979001341983 0.432173747969103 no 1430 0.434086737722746 2115 626179
SGTC_2712 st079126 47.7 µM 0.165164382477589 0.432488688088852 no 1431 0.434407299432554 2021 3152970
SGTC_312 4092-0653 6.84 µM 0.1646229637731 0.432698029929803 no 1432 0.43462037767169 2081 1148278
SGTC_2388 9080168 200 µM 0.16340913161279 0.433167431857317 no 1433 0.435098156767835 1935 15943073
SGTC_2788 5282734 71.43 µM 0.163226638302511 0.43323801215059 no 1434 0.43516999656611 2097 743706
SGTC_1279 0874-0590 65.2 µM 0.162277496493278 0.433605132263828 no 1435 0.435543667491012 2052 3523074
SGTC_960 1222-0186 7.7 µM 0.161252762891508 0.434001554958181 no 1436 0.435947163018225 2055 3126296
SGTC_1002 4049-0206 172 µM 0.158866453216929 0.434924965975424 no 1437 0.436887045717007 2014 4662749
SGTC_2248 tofa 1.1 µM 0.158109106964713 0.435218104612443 no 1438 0.43718541227909 2005 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2895 9054447 58.44 µM 0.156986476934463 0.43565269554569 no 1439 0.437627752897414 2013 2697450
SGTC_3293 9120939 62.045 µM 0.156874953140247 0.435695872730036 no 1440 0.437671699961066 2068 934087
SGTC_2849 9019321 12.99 µM 0.156688549464235 0.435768041873475 no 1441 0.437745155905405 2042 16489627
SGTC_3165 9101544 49.47 µM 0.156625214308102 0.435792563571976 no 1442 0.437770114827105 2082 5002184
SGTC_2101 5377231 179.231 µM 0.156382451079017 0.435886557363642 no 1443 0.437865784499179 2076 2844213
SGTC_1829 berberine 14.4 µM 0.155644268620696 0.436172391277751 no 1444 0.43815671441177 2126 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1661 st013063 9.66 µM 0.154168549495667 0.43674390884138 no 1445 0.438738419776167 2058 721395
SGTC_1374 2889-5571 141 µM 0.153945239393274 0.436830404071341 no 1446 0.43882645668108 2010 2853281
SGTC_1620 st003704 16.5 µM 0.153877355317648 0.436856698369609 no 1447 0.438853219634686 2126 2834414
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.151654015958124 0.437718042791766 no 1448 0.439729913752359 1971 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_486 niguldipine 82 µM 0.151242654353521 0.437877440971573 no 1449 0.439892151981458 2064 1236 A calcium channel blocker.
SGTC_207 4185-0010 4.486 µM 0.14975585564658 0.438453643294021 no 1450 0.440478619293518 2133 3761753
SGTC_1722 st034304 3.6505 µM 0.149220574891654 0.438661121013541 no 1451 0.440689792668125 2020 4036148 YLR033W RSC58
SGTC_2802 7925815 54.55 µM 0.148596548699945 0.438903018222364 no 1452 0.440935998256602 2045 1262923
SGTC_3019 9081971 49.47 µM 0.148343285883109 0.439001199412895 no 1453 0.44103592801841 2142 16451803
SGTC_2589 lobaric acid 100 µM 0.147947792431621 0.439154525980814 no 1454 0.441191985145506 2000 73157 A novel microtubule depolymerizer.
SGTC_467 ro 31-8220 72.8 µM 0.146064382366481 0.439884819203091 no 1455 0.441935281780435 2144 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1157 4092-0394 27.6 µM 0.145187428411886 0.440224928510473 no 1456 0.44228144571804 2123 3659885
SGTC_2085 5307070 144.047 µM 0.144963750047222 0.440311684825842 no 1457 0.442369746339835 2018 2840351
SGTC_1728 st035614 33.7865 µM 0.144951413216369 0.44031646989591 no 1458 0.442374616585026 2018 15945546
SGTC_2094 5332512 191.667 µM 0.144664012396112 0.440427946132656 no 1459 0.442488077073175 2143 755774
SGTC_185 k048-0037 25.491 µM 0.14371773114701 0.440795020411789 no 1460 0.442861684563374 2157 6827589
SGTC_1436 4092-1007 8.32 µM 0.143353182245049 0.440936447062642 no 1461 0.443005628076393 2115 2881121
SGTC_404 fumagillin 50 µM 0.143337353749386 0.440942587894152 no 1462 0.443011878188323 2044 12015870 A methionine aminopeptidase binder.
SGTC_1260 0700-1617 7.75 µM 0.1432270430912 0.440985384469421 no 1463 0.443055436351206 2055 2853078
SGTC_2755 lomerizine 42.69 µM 0.14204215422182 0.44144512217329 no 1464 0.443523354489844 2048 3949 A calcium channel blocker.
SGTC_805 3852-0218 479 µM 0.141175576975975 0.441781404738804 no 1465 0.443865619784894 1977 6615355
SGTC_1346 1488-2224 62.4 µM 0.140977657348543 0.441858215005276 no 1466 0.443943796448642 2167 3722427
SGTC_174 3553-0389 74.3 µM 0.140066084403114 0.442212013863412 no 1467 0.444303888556388 2100 738071
SGTC_752 1896-0090 130 µM 0.139863353397199 0.442290703912212 no 1468 0.444383978188601 2123 772567
SGTC_650 1328-0195 38 µM 0.139170193311142 0.442559771213884 no 1469 0.444657830775903 2177 2780821
SGTC_1305 1181-0477 144 µM 0.139094587993483 0.442589120900448 no 1470 0.444687702405159 2157 6252086
SGTC_1530 rhein 70.4 µM 0.135929450563331 0.443818095542823 no 1471 0.445938526682729 2161 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2373 9071805 200 µM 0.135838681469539 0.443853347827865 no 1472 0.445974405536041 2210 10149009
SGTC_177 1327-0068 8.361 µM 0.135763135770853 0.443882688092732 no 1473 0.446004267282448 2169 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_413 propylparaben 100 µM 0.135072777040692 0.444150822258778 no 1474 0.446277166837459 2030 7175 A pharmaceutical preservative.
SGTC_2964 9083345 53.42 µM 0.134756417426231 0.444273704348631 no 1475 0.446402232647039 2056 17741579
SGTC_1887 st057648 70.8 µM 0.132550708140528 0.445130605955237 no 1476 0.447274358759606 2170 688672
SGTC_1640 st009078 66.4 µM 0.13135998806799 0.445593298665099 no 1477 0.447745269614273 2165 690618
SGTC_3245 9134821 49.47 µM 0.130464200483208 0.445941434724672 no 1478 0.448099587949121 2102 17014901
SGTC_1445 4239-0156 97.7 µM 0.130191250971691 0.446047521258689 no 1479 0.448207558190275 2171 4008346
SGTC_2099 5377090 177.372 µM 0.129937369091424 0.446146200296272 no 1480 0.448307989320612 2062 2243829
SGTC_1295 1013-0063 9.78 µM 0.129660903023723 0.446253661169757 no 1481 0.448417358119637 2188 6826038
SGTC_1934 st074720 32.6 µM 0.129155262067668 0.446450211296456 no 1482 0.4486173976652 2152 17250992
SGTC_1777 st045864 34.765 µM 0.12731286854523 0.447166487892955 no 1483 0.449346387780463 2179 4691462
SGTC_134 0269-0018 6.916 µM 0.123843165201747 0.448515888044868 no 1484 0.450719726988579 2059 4378915
SGTC_2752 diclazuril 33.15 µM 0.122659661423335 0.448976300828894 no 1485 0.451188304050856 2181 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2299 7976368 114.88 µM 0.121471614879607 0.4494385499767 no 1486 0.451658748119825 2167 2979718
SGTC_3250 9135583 49.47 µM 0.120855172016681 0.449678424721903 no 1487 0.45190287468628 2203 7699353
SGTC_1139 k015-0024 46.9 µM 0.120727028444109 0.449728291195516 no 1488 0.45195362498567 2203 2766652
SGTC_2124 5246320 200 µM 0.119777234676172 0.450097923707055 no 1489 0.452329808094653 2107 579342
SGTC_2365 9042475 200 µM 0.118394135764935 0.450636263503352 no 1490 0.452877686040973 2077 6464479
SGTC_1694 st024011 44.9 µM 0.117948808055312 0.450809616564475 no 1491 0.453054109945488 2191 2787533
SGTC_2871 9038510 12.99 µM 0.117344279762807 0.451044956768138 no 1492 0.453293618604143 2206 4945164
SGTC_1674 st016616 23.6 µM 0.117210502040892 0.451097038174999 no 1493 0.453346622430364 2161 625830
SGTC_879 0831-1030 162 µM 0.115213237597666 0.451874698818781 no 1494 0.454138053231798 2166 1549252
SGTC_1847 st056231 15 µM 0.114835939843316 0.452021625391608 no 1495 0.454287580804407 2205 5393180
SGTC_1991 st073000 8.92 µM 0.112963576022976 0.452750854575871 no 1496 0.45502971622334 2177 4301969 YIL048W NEO1
SGTC_2345 9052315 157.45 µM 0.111376245922154 0.453369196672885 no 1497 0.455658997929899 2090 6469265
SGTC_3013 9080133 71.4286 µM 0.110758536906214 0.453609854952922 no 1498 0.455903912869989 2152 17050193
SGTC_3224 9130643 49.47 µM 0.109834720888376 0.453969803714016 no 1499 0.456270227165357 2155 17644395
SGTC_905 2-aminofluorene 215 µM 0.109362318845971 0.454153881540852 no 1500 0.456457559821741 2223 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1843 st055809 45.5 µM 0.109108907332601 0.454252630815467 no 1501 0.456558055020918 2114 16413835
SGTC_2161 5662504 8.5105 µM 0.109073530053289 0.454266416841451 no 1502 0.456572084781181 2109 2859334
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.108528648255416 0.454478756529949 no 1503 0.456788178349938 2170 6708561
SGTC_1068 loratadine 26.9 µM 0.108217199862389 0.454600133388283 no 1504 0.456911700781234 2099 3957 A H1 histamine antagonist.
SGTC_613 3914-0030 117 µM 0.107259419182813 0.454973423700739 no 1505 0.457291588781594 2188 1145395
SGTC_2253 7938677 135.83 µM 0.107108396932076 0.455032287518395 no 1506 0.457351492851787 2224 2301972
SGTC_2681 menadione 3.18 µM 0.105753171545629 0.45556055662794 no 1507 0.457889096024901 2148 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1846 st056244 14.8 µM 0.104397693641662 0.456089002774462 no 1508 0.458426876444911 2145 5393182
SGTC_660 4031-1742 102 µM 0.104266678119506 0.456140084572668 no 1509 0.458478860376842 2151 6738706
SGTC_1393 3470-5649 58.2 µM 0.103614538994157 0.456394358642374 no 1510 0.458737624660556 2146 4108395
SGTC_2939 9044578 71.43 µM 0.100709535305903 0.457527257471615 no 1511 0.459890520891259 2196 2653634
SGTC_250 brefeldin a 552.239 µM 0.0999813676107351 0.457811284155434 no 1512 0.460179558904245 2202 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1662 st014054 52 µM 0.0986018443826573 0.458349435384502 no 1513 0.460727202776929 2231 2838777
SGTC_2718 lomofungin 53.02 µM 0.0975037289483298 0.458777864220687 no 1514 0.461163186535006 2199 5351222 A RNA synthesis inhibitor.
SGTC_223 busulfan 5 mM 0.0964733575793953 0.459179906321413 no 1515 0.461572316391347 2212 2478 A DNA alkylator.
SGTC_1621 st003705 32.4 µM 0.0945233263177616 0.459940905801778 no 1516 0.462346726838239 2234 24207032
SGTC_1235 benzylparaben 21.5 µM 0.0943133771109271 0.460022847257356 no 1517 0.462430111942018 2182 7180
SGTC_1597 7-benzyloxygramine 47.5 µM 0.0941353230977598 0.460092341610879 no 1518 0.462500830590014 2152 260807
SGTC_1268 0828-0275 2.46 µM 0.0930201075781761 0.460527637074325 no 1519 0.462943793471403 2205 745337
SGTC_1623 st003709 20.3 µM 0.093011771458954 0.460530891041107 no 1520 0.46294710474627 2183 16192618
SGTC_1710 st031758 61.5 µM 0.0928249939293818 0.460603799505413 no 1521 0.463021297224956 2234 5394341
SGTC_785 1270-0111 65.3 µM 0.0927181695659715 0.460645498908621 no 1522 0.46306373098214 2272 6741994
SGTC_160 3453-0671 289.699 µM 0.092309969929708 0.460804845579311 no 1523 0.463225883667351 2218 5322268
SGTC_892 0929-0076 29 µM 0.0913070455193943 0.461196378399911 no 1524 0.463624309930748 2189 5751038
SGTC_2759 disulfiram 3.38 µM 0.0912386718096258 0.461223072265473 no 1525 0.463651473711335 2206 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_4 0960-0234 25.671 µM 0.0906185316407257 0.461465189928308 no 1526 0.46389785319823 2142 6821112
SGTC_472 calcifediol 10 µM 0.0903776415412468 0.461559243083424 no 1527 0.463993561718285 2145 5283731 A vitamin D metabolite.
SGTC_2658 polymyxin b sulfate 77.05 µM 0.0903018140039027 0.461588849640013 no 1528 0.464023689338 2170 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1266 0828-0227 32.9 µM 0.0902790487209258 0.461597738294627 no 1529 0.464032734427238 2180 3913820
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.089628829685369 0.461851622966514 no 1530 0.464291086913328 2235 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_333 3486-0131 40.1 µM 0.0885311648128662 0.462280252660811 no 1531 0.464727257819518 2250 6744690
SGTC_932 2857-0803 154 µM 0.0875439104866229 0.462665805319602 no 1532 0.46511959193209 2238 674898
SGTC_2485 5633444 17.78 µM 0.0872127406334869 0.462795145033237 no 1533 0.465251206192079 2141 5724239
SGTC_876 0720-0963 56.8 µM 0.0857361351576442 0.463371886899526 no 1534 0.465838088086427 2263 765861
SGTC_594 1487-1584 10.8 µM 0.085276027698188 0.463551614358892 no 1535 0.466020974612201 2199 5013332
SGTC_865 0488-0499 301 µM 0.0830938502851065 0.46440411853426 no 1536 0.466888457849342 2264 9634651
SGTC_1230 0170-0365 3.77 µM 0.0809283812587024 0.465250256879045 no 1537 0.467749454503576 2260 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_155 k072-0202 43.6 µM 0.0790931217929222 0.465967491864395 no 1538 0.468479277194804 2269 5857737
SGTC_372 0155-0182 15.9 µM 0.0781909997204257 0.466320089503406 no 1539 0.468838060640986 2186 771486
SGTC_2243 6634756 200 µM 0.07804823108112 0.466375893566859 no 1540 0.468894843559032 2261 885676
SGTC_2233 sulbentine 40.3845 µM 0.0772704752034051 0.466679907053079 no 1541 0.469204189019442 2244 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_551 k048-0028 34.9 µM 0.0771211884798739 0.466738263296344 no 1542 0.469263568614123 2251 6836383
SGTC_2351 9026858 72.31 µM 0.0766719313448445 0.466913882408686 no 1543 0.469442267167272 2244 1409300
SGTC_145 3737-0113 38.366 µM 0.0764981532257663 0.466981815744982 no 1544 0.469511391592094 2276 6849351
SGTC_829 1635-0120 117 µM 0.0760037924474577 0.467175076496675 no 1545 0.469708040495471 2261 285054
SGTC_2060 5238662 140 µM 0.075711526128834 0.467289335984364 no 1546 0.469824302895734 2196 790130
SGTC_3020 9089140 49.47 µM 0.075259711175538 0.467465975203529 no 1547 0.470004038178958 2199 17217859
SGTC_2002 4023503 131 µM 0.0742186150309209 0.467873021058396 no 1548 0.470418217023804 2298 4736863 YCR052W RSC6
SGTC_1941 st076221 61.8 µM 0.072923808182211 0.468379309080207 no 1549 0.4709333740952 2288 2828568
SGTC_2339 9000433 200 µM 0.0727913551077081 0.468431103026683 no 1550 0.470986075166334 2171 2988954
SGTC_2868 9035608 32.47 µM 0.0688704195601908 0.46996456901088 no 1551 0.472546382183144 2283 6462614
SGTC_1893 st059353 36.1 µM 0.0688638762480956 0.469967128459093 no 1552 0.472548986404166 2143 3112488
SGTC_1281 0884-0031 11.8 µM 0.0681606712160089 0.470242197723298 no 1553 0.472828866975937 2267 1548255
SGTC_1369 1866-0067 208 µM 0.068037032145267 0.47029056248391 no 1554 0.472878077590371 2262 3531355
SGTC_2951 9072950 58.06 µM 0.0679910935438569 0.470308532719845 no 1555 0.472896362100553 2308 16488155
SGTC_3078 9116413 49.47 µM 0.0676652360925541 0.47043600318562 no 1556 0.473026061719352 2276 17177322
SGTC_2511 berberine 10.47 µM 0.0675215370765035 0.470492217012672 no 1557 0.473083258520841 2265 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1683 st010134 710 nM 0.0668985992118082 0.470735911767193 no 1558 0.473331214104566 2288 3818134
SGTC_1689 st020265 53.493 µM 0.0668271976097028 0.47076384494329 no 1559 0.473359635620184 2282 5758320 YPR016C TIF6
SGTC_851 0394-0702 453 µM 0.066648320517971 0.470833824470786 no 1560 0.473430838511991 2298 762646
SGTC_1972 st070201 17.4 µM 0.066105284595921 0.471046274160112 no 1561 0.473647001778825 2285 2829099
SGTC_2564 betulinic acid 100 µM 0.0658863559231368 0.471131927049982 no 1562 0.473734151687354 2295 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_705 1124-0212 310 µM 0.064711210734958 0.471591709475611 no 1563 0.47420196832877 2298 9554485
SGTC_118 0083-0097 135.343 µM 0.0631335857295418 0.472209023911609 no 1564 0.4748300650448 2299 5207356
SGTC_1925 st057770 10.1 µM 0.0630591893283922 0.472238136401087 no 1565 0.474859685893416 2201 5989122
SGTC_2776 terbinafine 19.92 µM 0.0619338888208572 0.472678502302757 no 1566 0.475307739956795 2295 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2139 5578692 56.4705 µM 0.0609013094406931 0.473082612871847 no 1567 0.475718903300381 2312 650991 YMR113W FOL3
SGTC_2519 cryptotanshinone 88.04 µM 0.0600707216760307 0.473407692068568 no 1568 0.47604965427824 2300 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2722 naftopidil 47.16 µM 0.0583585989563147 0.474077846042948 no 1569 0.476731495892213 2296 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3331 9141060 1.957 µM 0.0578210356871887 0.474288272678465 no 1570 0.476945591076909 2257 4906567 YPR165W RHO1
SGTC_2537 larixol 68.93 µM 0.0572467916285451 0.474513065760995 no 1571 0.477174302459978 2299 6708759
SGTC_783 0848-0141 92.7 µM 0.056492042784797 0.474808531420607 no 1572 0.477474917170839 2303 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_111 0083-0039 52.457 µM 0.0542272608674864 0.475695220508758 no 1573 0.478377050800922 2313 759313
SGTC_1859 st055998 20 µM 0.0539551085732276 0.475801779560963 no 1574 0.478485465139022 2313 676301
SGTC_2442 5158906 48.48 µM 0.0532476921515467 0.476078770875016 no 1575 0.478767278322531 2286 1893835
SGTC_904 1141-0088 396 µM 0.0525898780105416 0.476336350622131 no 1576 0.479029340994425 2165 1378119
SGTC_266 formosanin C 406 nM 0.0522500347685999 0.476469426644076 no 1577 0.479164732685694 2306 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2832 7992762 51.95 µM 0.0507453907622906 0.477058647381564 no 1578 0.479764203310663 2243 2985177
SGTC_1691 st019933 84.6 µM 0.0482238051390309 0.478046215723318 no 1579 0.480768939248959 2329 6176082
SGTC_2917 7979103 53.79 µM 0.0480722542704437 0.478105574335273 no 1580 0.480829329258379 2286 2980565
SGTC_3232 9132874 49.47 µM 0.0477935984184268 0.478214717995694 no 1581 0.480940369224979 2300 3784940
SGTC_1888 azatryptophan 97.5 µM 0.0467626557481184 0.478618530785501 no 1582 0.481351196425139 2226 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_901 1112-0062 60.1 µM 0.0461606015411194 0.478854361243906 no 1583 0.481591122198145 2338 1908457
SGTC_1204 4049-0315 18.3 µM 0.0458273285807626 0.478984910675922 no 1584 0.481723938315426 2292 588402
SGTC_972 1319-0219 195 µM 0.0454629351722981 0.479127653166085 no 1585 0.481869158891192 2260 23903702
SGTC_2940 9060638 45.86 µM 0.0450379806269337 0.479294122427886 no 1586 0.482038517746595 2256 4027022
SGTC_3296 9122258 64.045 µM 0.0446366893934828 0.479451325275565 no 1587 0.482198448942708 2289 4730474
SGTC_1446 4239-0190 62 µM 0.0436690684879823 0.479830396647076 no 1588 0.482584097728352 2278 1340085
SGTC_2835 9006588 71.43 µM 0.0435015766487688 0.479896014454919 no 1589 0.482650853866774 2209 2345538
SGTC_2310 7668677 200 µM 0.0425119839924401 0.480283715452252 no 1590 0.483045279271671 2302 2197143
SGTC_3148 9097893 49.47 µM 0.0424595476707252 0.48030425939245 no 1591 0.483066179466068 2288 17174100
SGTC_891 0929-0073 133 µM 0.0417660782011694 0.480575957554801 no 1592 0.483342588539176 2307 5603632
SGTC_3174 9107204 49.47 µM 0.0414119063338019 0.480714723959653 no 1593 0.48348376052939 2320 3938802
SGTC_1801 st050089 28.441 µM 0.0413011768617289 0.480758108830914 no 1594 0.483527897436242 2325 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_3145 9085516 49.47 µM 0.0410364411338282 0.480861835756093 no 1595 0.483633422247562 2204 25236195
SGTC_2340 7987427 183.45 µM 0.0409568357419101 0.480893026444884 no 1596 0.483665153527163 2322 2239331
SGTC_3200 9114385 49.47 µM 0.040654968776137 0.481011303898648 no 1597 0.483785480800921 2272 17018030 YLR208W SEC13
SGTC_474 dl-dihydrosphingosine 5 µM 0.0405155749238037 0.481065921734621 no 1598 0.483841045121568 2315 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2971 9092186 9.93 µM 0.0404637437650357 0.481086230509536 no 1599 0.483861705819593 2276 25236400
SGTC_132 0417-1715 25.805 µM 0.0401499819586641 0.48120917146388 no 1600 0.483986777030296 2343 6769098
SGTC_1384 3089-0840 101 µM 0.0400601028543976 0.48124438902737 no 1601 0.484022604780576 2326 1069836
SGTC_2383 9036125 200 µM 0.039645771742708 0.48140673935431 no 1602 0.48418776776524 2241 79580
SGTC_728 3030-5151 22.5 µM 0.0393350005742533 0.481528513072388 no 1603 0.484311650888415 2327 3125388
SGTC_1395 3486-0190 4.35 µM 0.0392458552578711 0.481563444419759 no 1604 0.484347187284182 2344 6748079
SGTC_2012 4023501 200 µM 0.0390368241040026 0.481645353257887 no 1605 0.48443051479405 2290 3477460
SGTC_3212 9128307 49.47 µM 0.0370946164656248 0.482406443728993 no 1606 0.485204782257042 2208 27243542
SGTC_2784 7567673 72.73 µM 0.0353397710906997 0.483094168003157 no 1607 0.485904405189962 2341 3471247
SGTC_2386 9075165 157.42 µM 0.0348811056281648 0.483273927470192 no 1608 0.486087273484386 2321 16452277
SGTC_2934 9036370 36.88 µM 0.0338149417866337 0.483691789848189 no 1609 0.486512360468521 2322 6462800
SGTC_1982 st072467 71.9 µM 0.033349422041756 0.483874246988978 no 1610 0.486697971283426 2285 3163533
SGTC_2606 farnesol 9.78 µM 0.0329822378637298 0.484018164590387 no 1611 0.486844376033183 2340 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_41 0478-0632 82.643 µM 0.0328242383457896 0.484080093041215 no 1612 0.486907374610019 2355 3750424
SGTC_1844 rapamycin 4 nM 0.0316462027459379 0.484541840123807 no 1613 0.487377098680703 2331 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_925 2064-1272 59.6 µM 0.0291543270919511 0.485518632237246 no 1614 0.488370753717391 2307 6815817
SGTC_2260 7964312 200 µM 0.0281278790267486 0.485921015949627 no 1615 0.488780079309332 2350 231951
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.0279028985638967 0.48600921374314 no 1616 0.488869798312611 2361 688667
SGTC_190 3970-0790 3.722 µM 0.0277354554570123 0.48607485594324 no 1617 0.488936572603898 2368 2832352
SGTC_1122 capsaicin 818.572 nM 0.0269601425569922 0.486378804336864 no 1618 0.489245762049176 2318 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_387 norethindrone acetate 66.7 µM 0.0262192080245727 0.486669282666137 no 1619 0.489541247680175 2328 541197
SGTC_1276 0871-0068 94.2 µM 0.0259428676273019 0.486777621852991 no 1620 0.489651454059382 2357 3414906
SGTC_1060 3448-7350 82 µM 0.0256304540591118 0.486900104692726 no 1621 0.489776047608954 2351 570178
SGTC_2434 5670830 169.91 µM 0.0256204702229424 0.486904018911297 no 1622 0.489780029275798 2327 1549830
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.0253018457450903 0.487028938072836 no 1623 0.489907100855988 2371 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_168 3970-0862 530.542 µM 0.0248177959835456 0.487218715912379 no 1624 0.490100148143956 2314 3135186
SGTC_1465 k213-0056 144 µM 0.0240323710108176 0.487526657859844 no 1625 0.490413393912856 2323 24048857 YMR208W ERG12
SGTC_1286 0929-0070 131 µM 0.0236265086566932 0.487685787434553 no 1626 0.490575263600084 2329 1420408
SGTC_1040 k898-0338 155 µM 0.0235572237488461 0.487712952697855 no 1627 0.490602896588211 2360 20969351
SGTC_2021 4019055 173 µM 0.0223165897197057 0.488199390673475 no 1628 0.491097707747601 2353 44827708 YER133W GLC7
SGTC_1613 st002381 52.1 µM 0.0222689091646677 0.488218086011883 no 1629 0.491116724810946 2373 551167
SGTC_1505 k297-0037 20.6 µM 0.0220534780556047 0.488302555935614 no 1630 0.491202648286804 2357 4089396
SGTC_564 3555-0129 330 µM 0.0219150587145328 0.488356830041775 no 1631 0.491257856271495 2372 563260
SGTC_792 4534-1957 155 µM 0.0217183106559637 0.488433975159372 no 1632 0.491336328713121 2270 1717904
SGTC_60 0986-0278 202 µM 0.0214968701690349 0.48852080272118 no 1633 0.491424650065274 2327 3110598
SGTC_1030 k029-0042 36.7 µM 0.0214452970147133 0.488541024807199 no 1634 0.491445220035063 2259 6080581
SGTC_469 w7 172 µM 0.0211950600384628 0.488639144366622 no 1635 0.491545027458439 2371 45115570 A P450 inhibitor.
SGTC_296 1222-0039 74.9 µM 0.0203620946951769 0.488965760460911 no 1636 0.491877260813884 2359 5984176
SGTC_2208 7283366 200 µM 0.0201300510043641 0.489056749011811 no 1637 0.491969813881987 2369 898663
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0199485294888775 0.489127927296286 no 1638 0.492042215950394 2359 688803
SGTC_2807 7945238 51.95 µM 0.0196894966074137 0.489229499965605 no 1639 0.492145534825063 2360 17148797
SGTC_2568 diosmetin 100 µM 0.0193920887933519 0.4893461211776 no 1640 0.492264160725805 2374 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1371 2421-0008 32.7 µM 0.0184985744255071 0.489696496457527 no 1641 0.492620557407747 2361 2827552
SGTC_2962 9082311 13.18 µM 0.0177606784403748 0.489985854847813 no 1642 0.492914886933495 2366 16459453
SGTC_1608 st001473 40.5 µM 0.0176114070437556 0.490044390750558 no 1643 0.492974428291925 2363 7292267
SGTC_2638 epoxomicin 18 µM 0.0171068802594117 0.490242239549869 no 1644 0.493175675031543 2373 9915668 A protesome inhibitor.
SGTC_1021 4476-0760 85.3 µM 0.0170746758032813 0.49025486852134 no 1645 0.493188520874472 2368 746768
SGTC_1175 0741-0056 27.6 µM 0.0157873887017442 0.490759685783831 no 1646 0.493702004771274 2368 765927
SGTC_468 gf-109203x 121 µM 0.0156608657289 0.490809303329124 no 1647 0.493752473894965 2374 2396 A protein kinase C inhibitor.
SGTC_1144 3486-0183 12.5 µM 0.013502209798524 0.491655868172619 no 1648 0.494613561299659 2369 6744069
SGTC_2651 TUB2.036 5 µM 0.0134474111664 0.491677359177993 no 1649 0.494635420806307 2365 15992207 YFL037W TUB2
SGTC_2075 5212009 200 µM 0.0131888488996952 0.491778762819858 no 1650 0.494738563078614 2373 780898
SGTC_211 3455-0679 143.504 µM 0.0109155105791374 0.492670348866793 no 1651 0.495645427791349 2339 748649
SGTC_811 0416-0114 265 µM 0.0105192832552349 0.492825750090855 no 1652 0.49580349054446 2355 6612453
SGTC_544 k015-0020 52.4 µM 0.00963171665639219 0.49317385957037 no 1653 0.496157560403509 2378 3008304
SGTC_510 ag-490 170 µM 0.00905254874875983 0.493401015866653 no 1654 0.496388604883611 2385 5328779
SGTC_2079 5212404 121 µM 0.00703735092258382 0.49419141576982 no 1655 0.49719252634801 2388 758462
SGTC_2700 st077718 96.8 µM 0.00662043023112118 0.494354943148404 no 1656 0.497358849760017 2391 904970
SGTC_1394 3474-0001 65.7 µM 0.00661957832059994 0.494355277291338 no 1657 0.497359189615696 2381 5017666 YIL048W NEO1
SGTC_1462 k081-0014 26.5 µM 0.00641126335096124 0.49443698431834 no 1658 0.497442293500647 2376 3270634
SGTC_3210 9128157 49.47 µM 0.00563083944868591 0.494743090708094 no 1659 0.497753631940463 2369 17590849
SGTC_2913 7966556 36.57 µM 0.00562898285685588 0.494743818924589 no 1660 0.497754372601703 2396 2976516
SGTC_2336 9001819 198.65 µM 0.00502927702384586 0.494979044216881 no 1661 0.497993617213456 2395 2989602
SGTC_518 1021-0119 62.6 µM 0.00488334026195902 0.495036285910786 no 1662 0.498051836842899 2376 1097762
SGTC_336 4111-0029 111 µM 0.00224358344379208 0.49607171081391 no 1663 0.499104940455568 2397 3131175
SGTC_2193 5925765 200 µM 0.00160866662264304 0.496320756408152 no 1664 0.499358235145951 2392 877370
SGTC_3182 9108849 49.47 µM 0.00107522345073847 0.496530000160469 no 1665 0.499571047987274 2399 17133045
SGTC_767 0929-0023 86 µM 0.000394164011989 0.496797147958072 no 1666 0.499842751314277 2403 1204563
SGTC_2882 9058044 58.44 µM -0.000185729799763065 0.497024614343613 no 1667 0.49992590453057 2403 18076804
SGTC_1808 st050063 61.5 µM -0.00175348812258426 0.497639580391254 no 1668 0.499300459808201 2407 4011993
SGTC_2108 5365811 200 µM -0.00265853763802616 0.497994596126645 no 1669 0.498939398181511 2419 780283
SGTC_558 k064-0027 21.3 µM -0.00300311123673877 0.498129759384617 no 1670 0.498801933755745 2413 5088526
SGTC_543 3844-1095 191 µM -0.00343708856731459 0.498299992666283 no 1671 0.498628802748805 2414 4230703
SGTC_127 0180-0333 59.125 µM -0.0045546342795876 0.498738365932517 no 1672 0.498182970096397 2414 771601
SGTC_870 0573-2213 57.6 µM -0.00561176588338343 0.499153042312723 no 1673 0.497761241071878 2418 3916321
SGTC_2825 7998094 58.44 µM -0.0057114986931308 0.499192164119037 no 1674 0.497721454075016 2423 2987815
SGTC_2482 5981709 142.65 µM -0.00583809464623682 0.499241823438584 no 1675 0.49767095043894 2424 877755
SGTC_2908 7930301 100 µM -0.00631950254115395 0.499430663608032 no 1676 0.497478900025729 2420 2223178
SGTC_895 0964-0006 13.7 µM -0.00679292416410429 0.499616371155508 no 1677 0.497290036184741 2404 6738897
SGTC_2159 5658611 73.75 µM -0.00774161453181838 0.499988511024543 no 1678 0.496911573494288 2413 793844
SGTC_2009 4012297 12.05 µM -0.00780019185463659 0.499988511024543 no 1679 0.496888205229126 2429 45595307
SGTC_2949 9072542 2.23 µM -0.00863279395158051 0.499661908735015 no 1680 0.4965560562715 2428 16457352
SGTC_2873 9040596 71.43 µM -0.00879396662973284 0.499598686038662 no 1681 0.496491760116634 2465 6463863
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.0101728118021529 0.499057811382249 no 1682 0.495941705257858 2420 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2580 diallyl disulphide 81.36 µM -0.0118784283944719 0.498388757776326 no 1683 0.495261304124997 2439 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_552 k242-0005 476 µM -0.0126195874413789 0.498098028362365 no 1684 0.49496564663224 2444 4088318
SGTC_525 k781-2675 26.7 µM -0.0130336723306316 0.497935598531634 no 1685 0.494800464252084 2424 3651118 YDL195W SEC31
SGTC_3017 9080681 49.47 µM -0.013046713358668 0.497930483035299 no 1686 0.494795262076946 2445 16451914
SGTC_230 MPP+ 141.667 µM -0.0131644667679895 0.497884292893706 no 1687 0.494748289297446 2437 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_249 wiskostatin 11.211 µM -0.0132428798612294 0.497853534463421 no 1688 0.494717009725936 2423 2775510 A n-wasp and actin depolymerizer.
SGTC_2016 5121758 140 µM -0.0135393630584767 0.497737235664164 no 1689 0.494598740648166 2431 2795203
SGTC_3336 9143619 71.43 µM -0.0147215305839502 0.497273519443091 no 1690 0.494127171148573 2426 45595730
SGTC_505 gw-5074 63.9 µM -0.0149318237700804 0.497191030350378 no 1691 0.49404328552631 2484 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1497 4476-2978 41.3 µM -0.0157254015479893 0.496879744576247 no 1692 0.493726730998239 2480 1528379
SGTC_1420 4'-methoxyflavone 42 µM -0.0174139164687199 0.496217420750944 no 1693 0.49305320355131 2434 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1162 k048-0130 20.1 µM -0.0187125023330827 0.4957080544836 no 1694 0.492535227291093 2443 6797406
SGTC_1415 3966-0071 78.1 µM -0.0192304414490784 0.495504896381426 no 1695 0.492328636662416 2453 2893185
SGTC_2796 7949634 45.45 µM -0.0193703345743477 0.495450024450478 no 1696 0.492272837773704 2434 2971588
SGTC_1074 carmofur 3.8 µM -0.0200619811086697 0.49517873305545 no 1697 0.491996964358485 2433 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2135 5326629 150.42 µM -0.0205668219346994 0.494980715720797 no 1698 0.491795603562807 2454 5020077
SGTC_1015 4130-4525 82 µM -0.0207883262500321 0.494893833883467 no 1699 0.491707255015573 2457 1363237
SGTC_2474 5321570 43.32 µM -0.0212890559262048 0.494697430869496 no 1700 0.491507536983923 2520 2841384
SGTC_382 3229-0966 23.2 µM -0.0227966277084782 0.494106118483559 no 1701 0.490906249012874 2457 5722370
SGTC_1165 k072-0275 30.3 µM -0.023489080719618 0.493834523046286 no 1702 0.490630074203427 2452 6153523 YGL055W OLE1
SGTC_653 0203-0016 55.2 µM -0.0238324378507819 0.493699851812039 no 1703 0.490493132864606 2475 295302
SGTC_349 k015-0014 24 µM -0.0238630654335716 0.493687839122909 no 1704 0.490480917700854 2452 2196908
SGTC_143 4032-1194 15.74 µM -0.0241459448930508 0.493576888980331 no 1705 0.490368097633648 2438 1806963
SGTC_740 k014-0057 261 µM -0.0251837750639047 0.493169838629844 no 1706 0.489954189238025 2488 4012779
SGTC_2272 7805186 180 µM -0.0252111671111531 0.49315909521083 no 1707 0.489943264860794 2444 2956062 YPR165W RHO1
SGTC_1310 1188-0297 994 nM -0.0272673856729533 0.49235264163346 no 1708 0.48912323482694 2466 1588352
SGTC_2491 paeonol 100 µM -0.0275772694113003 0.492231107158704 no 1709 0.488999655575748 2452 11092 Increases levels of cortical cytochrome oxidase.
SGTC_188 3229-0966 278.469 µM -0.0289434336343056 0.491695314798721 no 1710 0.488454852543794 2470 5722370
SGTC_914 3820-6779 408 µM -0.0294166383978107 0.491509733309496 no 1711 0.488266151512267 2468 2893481
SGTC_1155 4088-0394 48.2 µM -0.0301092416127878 0.491238111439317 no 1712 0.487989965166317 2457 2326248
SGTC_49 0717-0965 32.132 µM -0.0301515200512476 0.49122153101054 no 1713 0.487973106164041 2649 5889349 YGL099W LSG1
SGTC_1739 st037196 92.5 µM -0.0305526788727403 0.49106420842651 no 1714 0.487813140651147 2461 612214
SGTC_2624 nerol 100 µM -0.0316502219336309 0.490633791787845 no 1715 0.4873754960596 2458 637566 A natural product oil.
SGTC_1703 st026983 48.3 µM -0.0316568666357648 0.490631186009028 no 1716 0.487372846534653 2461 1104023
SGTC_1788 fluconazole 20 µM -0.0316912955566642 0.490617684409046 no 1717 0.487359118270588 2526 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1160 4092-0570 10.5 µM -0.0324697677602241 0.490312402680981 no 1718 0.487048712572052 2463 4994975
SGTC_2821 7996764 71.43 µM -0.0348286494908327 0.48938739092329 no 1719 0.486108187747596 2499 2987135
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.0349288851951543 0.489348085728574 no 1720 0.486068223803185 2455 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1700 st030840 7.9285 µM -0.0349614493028506 0.489335316462644 no 1721 0.486055240533578 2491 5499307
SGTC_3233 9132340 49.47 µM -0.0358989632138653 0.488967696682694 no 1722 0.485681461285783 2475 17682950
SGTC_232 clozapine 119 µM -0.0364924565495492 0.488734979745394 no 1723 0.48544484675312 2459 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2468 5987765 72.9 µM -0.0366612810791089 0.488668782011883 no 1724 0.485377540548838 2527 26772094
SGTC_2761 levamisole 97.89 µM -0.0382165057583264 0.488058978266789 no 1725 0.484757530408552 2486 26879 An alkaline phosphatase inhibitor.
SGTC_2411 st077133 39.94 µM -0.0382346742867357 0.488051854547254 no 1726 0.484750287507978 2689 1403142 YNL221C POP1
SGTC_691 1548-0686 185 µM -0.0384503643555267 0.487967284668016 no 1727 0.484664302848599 2499 46495133
SGTC_1359 1582-0056 520 nM -0.0391438397622807 0.487695383709096 no 1728 0.48438785432952 2514 3661189
SGTC_2174 5790901 200 µM -0.0392145415408226 0.487667662956671 no 1729 0.484359670040638 2501 786020
SGTC_3179 9107801 49.47 µM -0.0398985273290457 0.487399488913904 no 1730 0.484087012595499 2486 4818259
SGTC_2567 aureobasidin a 60 nM -0.0399430683530788 0.487382025667683 no 1731 0.48406925745136 2588 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2191 5911152 200 µM -0.0401399178216993 0.487304846979319 no 1732 0.483990788806021 2482 2875902
SGTC_2531 methyl deoxycholate 70.07 µM -0.0404679124823161 0.487176251308208 no 1733 0.483860044103089 2497 16667744 Haematoxylin.
SGTC_923 1900-2434 73.3 µM -0.0407036507868765 0.487083827073122 no 1734 0.483766075551152 2470 5910570
SGTC_1179 1021-1431 9.29 µM -0.040908925040935 0.487003347225824 no 1735 0.48368425112574 2526 2840958
SGTC_631 k072-0230 41.5 µM -0.0424483464427505 0.486399818590969 no 1736 0.483070644084311 2533 5773147
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.0427375131399928 0.486286454507187 no 1737 0.482955387857013 2483 229346 A bile salt which induces apoptosis.
SGTC_106 0092-0003 11.579 µM -0.043422332536312 0.486017984309089 no 1738 0.482682437849458 2566 1072148
SGTC_3264 9137442 49.47 µM -0.0437778363875044 0.485878618391657 no 1739 0.482540747071913 2505 17015726
SGTC_59 0330-0160 1.33 µM -0.0456193256826243 0.485156739021732 no 1740 0.481806832769974 2513 4293482
SGTC_3325 9138760 55.175 µM -0.0457084889943801 0.48512178746541 no 1741 0.481771298821945 2508 43844959
SGTC_1521 st012942 49.4 µM -0.0471126926754758 0.484571362145517 no 1742 0.481211705639722 2641 24207259
SGTC_1552 6-methylflavone 10.6 µM -0.0474450540925328 0.484441086064564 no 1743 0.481079260727961 2502 689013
SGTC_282 k297-0036 65.7 µM -0.0489984647270501 0.48383221618645 no 1744 0.480460259721044 2531 5061378
SGTC_2198 6589944 200 µM -0.0490536736073868 0.483810577375124 no 1745 0.48043826101787 2499 5290268
SGTC_1435 4092-0789 56.7 µM -0.0502454032844994 0.483343497334924 no 1746 0.479963415317284 2482 2248285
SGTC_3281 9140613 49.47 µM -0.050613393991525 0.483199273650054 no 1747 0.479816794821935 2518 16013766
SGTC_2377 9073351 62.6 µM -0.0509351223996073 0.483073182982294 no 1748 0.479688609097256 2491 7337946 YHR072W ERG7
SGTC_963 1269-2853 151 µM -0.0517684288009011 0.482746604366135 no 1749 0.479356605986464 2526 3668223
SGTC_572 0960-0087 17.7 µM -0.0529521206910347 0.482282727175472 no 1750 0.478885028153795 2488 6796365
SGTC_3096 9117468 49.47 µM -0.0529938538652828 0.482266372789652 no 1751 0.478868402369583 2496 41316311
SGTC_2810 7959871 45.46 µM -0.0530951778934936 0.482226666079213 no 1752 0.478828036759468 2552 2974535
SGTC_1646 st011709 75.6 µM -0.0532341046138456 0.482172223968007 no 1753 0.478772691288589 2494 5757843
SGTC_2520 obtusaquinone 4.71 µM -0.0560441053364124 0.481071123596368 no 1754 0.477653335687715 2544 5967872
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.0561236257421184 0.481039965541866 no 1755 0.477621661488936 2495 5355888
SGTC_80 0159-0065 512.242 µM -0.0583314168522371 0.480174945507062 no 1756 0.476742321541097 2496 1548079
SGTC_259 usnic acid 108.925 µM -0.0593046782078847 0.479793647817019 no 1757 0.476354717502179 2626 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2701 st077767 14.721 µM -0.0617996294139034 0.478816278143598 no 1758 0.475361199305055 2539 5721188
SGTC_836 0330-0104 1.35 µM -0.0618762931921287 0.478786247939282 no 1759 0.475330673303084 2523 46494820
SGTC_445 e6 berbamine 66 µM -0.0621067322814711 0.478695982660698 no 1760 0.475238917882622 2576 6610268 A calcium/calmodulin antagonist.
SGTC_609 0986-0026 86.3 µM -0.0628779878616798 0.478393882169596 no 1761 0.474931831647272 2513 2848610
SGTC_2162 5663267 200 µM -0.0630442513250535 0.478328758460424 no 1762 0.474865633460441 2517 6456493
SGTC_1138 3761-0006 1.03 µM -0.0630962252009502 0.478308400939979 no 1763 0.474844940082457 2500 12061087
SGTC_303 1348-1668 34.2 µM -0.0639740963320062 0.477964558335279 no 1764 0.474495426339108 2550 5380509
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.065480999166273 0.477374376380311 no 1765 0.473895517166279 2553 6728940
SGTC_1789 tunicamycin 25 nM -0.0661608173763888 0.477108140181866 no 1766 0.473624895798787 2601 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1326 1431-2094 10.8 µM -0.0662319675946802 0.477080276315873 no 1767 0.473596573091006 2526 616278
SGTC_629 3448-6466 76.7 µM -0.0663120251100981 0.477048924305969 no 1768 0.473564704822506 2533 573744
SGTC_343 4130-2827 29.8 µM -0.0667694870908471 0.476869776429062 no 1769 0.473382607478535 2554 1118244
SGTC_368 fentichlor 4.58 µM -0.0668348413877864 0.476844183243517 no 1770 0.473356592996282 2571 7329 A pesticide.
SGTC_3089 9117425 49.47 µM -0.0679239248461467 0.476417704919943 no 1771 0.472923096729415 2583 9401657
SGTC_3207 9114163 49.47 µM -0.0699059170625756 0.475641638718016 no 1772 0.472134271759404 2563 849233
SGTC_1423 4048-0112 5.59 µM -0.0716192402842429 0.474970846536811 no 1773 0.471452463930839 2566 X1423
SGTC_73 0327-0325 16.231 µM -0.0741791221423998 0.47396874649436 no 1774 0.470433929096038 2692 53298
SGTC_593 1203-0218 61.7 µM -0.0759076323067204 0.47329219079494 no 1775 0.469746292339371 2590 3666956
SGTC_1617 st002906 78 µM -0.0767054538360849 0.472979941550026 no 1776 0.469428932896341 2550 5150859
SGTC_2497 7-hydroxyflavone 100 µM -0.0767796803807162 0.472950891805813 no 1777 0.469399407860195 2672 5281894
SGTC_1997 st073024 93.8 µM -0.0769861463917158 0.472870088790653 no 1778 0.469317282917662 2526 686268
SGTC_637 1181-0519 7.26 µM -0.0769967765061799 0.472865928594683 no 1779 0.469313054666019 2536 6252091 YGR060W ERG25
SGTC_921 1561-0023 372 µM -0.077091229745856 0.472828963554844 no 1780 0.469275484943607 2525 24050882
SGTC_1899 st063254 59.6 µM -0.0772380926674682 0.472771488026676 no 1781 0.469217069288599 2530 3093813
SGTC_1792 st045773 43.6 µM -0.0773724855157219 0.472718893219896 no 1782 0.469163614264651 2546 2919270
SGTC_2870 9038528 12.99 µM -0.0784757820564545 0.472287134822576 no 1783 0.46872479696021 2698 6463316
SGTC_745 0469-0705 296 µM -0.0792971424812706 0.471965728971495 no 1784 0.468398139557973 2577 3486736
SGTC_319 1348-1596 45.5 µM -0.0801067579554612 0.471648936891509 no 1785 0.468076173976192 2670 5380505
SGTC_1878 temozolomide 1 mM -0.0802771206186484 0.471582278458944 no 1786 0.468008427288415 2525 5394 DNA alkylating agent.
SGTC_2216 7189485 200 µM -0.0813050535515521 0.471180092277665 no 1787 0.467599677572705 2577 731273
SGTC_1264 0783-0040 158 µM -0.0821770965520729 0.470838922184484 no 1788 0.467252943068732 2550 2855798
SGTC_1647 st011722 22.4 µM -0.0822199122095085 0.470822171929111 no 1789 0.467235919699968 2618 2854783
SGTC_2429 5902844 64.44 µM -0.0828260885641104 0.470585030387931 no 1790 0.466994912360628 2654 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2000 st075254 36.4 µM -0.0831384943507929 0.470462818554159 no 1791 0.46687070885764 2556 17234175
SGTC_1028 k015-0029 4.8 µM -0.0836179071284037 0.47027527970012 no 1792 0.466680114484284 2554 4588309
SGTC_2215 7188065 200 µM -0.0838669568073461 0.470177857922146 no 1793 0.466581105810808 2626 940217
SGTC_187 1488-2104 32.728 µM -0.0841638665906906 0.470061716845081 no 1794 0.466463073252848 2626 2852859
SGTC_194 1486-1323 56.904 µM -0.0857718322743286 0.469432779486712 no 1795 0.465823899263821 2576 5178754
SGTC_2289 7946404 165.07 µM -0.0859573809641041 0.469360209120181 no 1796 0.46575014842078 2576 1246120 YPR165W RHO1
SGTC_3188 9110789 49.47 µM -0.0860340697190709 0.469330215505414 no 1797 0.465719666951902 2627 849217
SGTC_2854 9024559 71.43 µM -0.0863982634795858 0.469187778652263 no 1798 0.465574913656445 2618 3163529
SGTC_3248 9135562 49.47 µM -0.0867415575543524 0.469053519314942 no 1799 0.46543847136828 2583 17650701
SGTC_2641 levomentholum 100 µM -0.0871683937169065 0.468886592300554 no 1800 0.465268830931269 2560 16666
SGTC_90 0870-0863 4.608 µM -0.087776511061231 0.468648779326195 no 1801 0.465027153574426 2556 1738164
SGTC_1626 st003712 1.76 µM -0.0879739529208491 0.468571569267992 no 1802 0.464948689207572 2659 24207035
SGTC_2054 5233173 129 µM -0.0881324053039448 0.468509606982165 no 1803 0.464885720436221 2649 6889
SGTC_1304 1165-0502 251 µM -0.0891212645623089 0.468122934099196 no 1804 0.4644927689801 2597 767425
SGTC_2268 7933382 153.85 µM -0.0911147205405679 0.467343526316182 no 1805 0.46370071799869 2540 935025 YOR257W CDC31
SGTC_2610 ononetin 44.17 µM -0.0920295515508546 0.466985884494519 no 1806 0.463337280236484 2640 259632
SGTC_450 aminopyrene 156 nM -0.09213728144595 0.466943770578488 no 1807 0.463294484053686 2574 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2245 6637752 200 µM -0.09372994424626 0.466321208114079 no 1808 0.462661841456407 2694 681890
SGTC_3315 9136395 68.55 µM -0.0937886462151546 0.466298263426953 no 1809 0.462638525467793 2578 16876844
SGTC_1362 1611-0397 101 µM -0.0940726028610098 0.466187275608196 no 1810 0.462525741798431 2586 27816
SGTC_1228 0124-0032 52.5 µM -0.0942818782783154 0.466105479514943 no 1811 0.46244262241248 2622 X1228
SGTC_2623 humulene 100 µM -0.0944139004622685 0.46605387887822 no 1812 0.46239018707871 2621 6187145 An anti-inflammatory.
SGTC_3328 9140624 29.0385 µM -0.0951179116053798 0.465778727026219 no 1813 0.462110585587931 2612 4904392
SGTC_2049 5262831 67.185 µM -0.0957765348088735 0.465521329155025 no 1814 0.46184902708906 2596 763417
SGTC_1159 4092-0538 61.2 µM -0.0964791441165639 0.465246756888836 no 1815 0.461570018615401 2578 717301
SGTC_54 0159-0055 9 µM -0.0967967554513737 0.46512264316967 no 1816 0.461443900305528 2574 3319099
SGTC_2495 cafestol 54.53 µM -0.0971441372405288 0.464986899866154 no 1817 0.46130596507098 2780 16667697 An anti-infammatory.
SGTC_65 0798-0905 34.986 µM -0.0973906734778807 0.46489056555629 no 1818 0.461208075503543 2773 3602145
SGTC_760 0568-0725 82.9 µM -0.0980723325391857 0.464624217245333 no 1819 0.460937428514839 2681 3916171
SGTC_1146 3579-1023 7 µM -0.100921273862011 0.463511207999778 no 1820 0.459806477613317 2700 X1146
SGTC_642 0335-0876 158 µM -0.10099867841832 0.463480971944444 no 1821 0.459775754641143 2593 6812350
SGTC_1917 st066507 28.5 µM -0.101913713825525 0.463123553448572 no 1822 0.459412582291741 2572 3156428
SGTC_715 0868-0130 184 µM -0.102091675805747 0.463054043845773 no 1823 0.45934195411818 2642 2876258
SGTC_712 r015-0009 80.6 µM -0.103055282588063 0.462677691387116 no 1824 0.458959547656616 2664 6813872 YLR060W FRS1
SGTC_950 1165-0508 94.1 µM -0.105335218910812 0.461787358440411 no 1825 0.45805490888163 2658 6148369
SGTC_855 0428-0020 25 µM -0.106386297789247 0.461376968134496 no 1826 0.457637932079402 2613 6812414
SGTC_800 3448-7362 155 µM -0.10704061046827 0.461121514632802 no 1827 0.457378381159056 2585 15991913
SGTC_251 melphalan 456.522 µM -0.107829827592258 0.460813413761758 no 1828 0.457065340917415 2650 460612 A DNA alkylator.
SGTC_491 tetrandrine 80.3 µM -0.107930242371129 0.460774214723002 no 1829 0.45702551364908 2687 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3298 9116858 71.43 µM -0.109369680228065 0.460212341703645 no 1830 0.456454640565986 2718 2506942
SGTC_422 cantharidin 155 µM -0.109376322199852 0.460209749246509 no 1831 0.456452006604147 2584 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1177 0983-0204 23.6 µM -0.109574756556149 0.460132298243326 no 1832 0.456373315716326 2664 766818
SGTC_619 1652-1634 108 µM -0.110633361164953 0.459719139432164 no 1833 0.455953545741663 2660 5400454
SGTC_1525 8-methoxypsoralen 92.5 µM -0.111462535023407 0.459395554639044 no 1834 0.45562478657419 2644 4114 Related to psoralen; DNA damaging agent.
SGTC_255 tunicamycin 200.472 nM -0.11263419841866 0.458938359336186 no 1835 0.455160285572129 2701 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1637 st007924 17.4 µM -0.113637069367042 0.458547071721548 no 1836 0.45476275028466 2598 683336
SGTC_3137 9097352 49.47 µM -0.115611754483088 0.457776731589957 no 1837 0.453980123324811 2831 44120435
SGTC_2313 7726885 200 µM -0.115856419558886 0.457681296810693 no 1838 0.453883167591897 2703 726423
SGTC_2611 pyromycin 23.93 µM -0.11706195529342 0.457211097730012 no 1839 0.453405478838927 2669 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_71 0417-1750 47.813 µM -0.117178609341124 0.457165601934493 no 1840 0.453359258701258 2656 6811472
SGTC_2412 st077135 33.4 µM -0.120063083667443 0.456040819267088 no 1841 0.452216587881644 2909 13258915
SGTC_2986 9022445 71.43 µM -0.120182462427359 0.455994275796376 no 1842 0.452169305014129 2643 6459286
SGTC_1939 st074455 53.6 µM -0.12029231894058 0.455951445399086 no 1843 0.452125794263857 2787 1644229
SGTC_1664 st014217 9.02 µM -0.120365926194858 0.45592274799741 no 1844 0.452096641039999 2636 3982782
SGTC_3166 9102297 49.47 µM -0.120990589533458 0.455679218572073 no 1845 0.451849244450082 2678 25237072
SGTC_2894 9048625 32.47 µM -0.122022745072503 0.455276861958135 no 1846 0.451440502454733 2700 4092861
SGTC_2074 5212007 75.395 µM -0.122152268934583 0.455226373978552 no 1847 0.451389213577338 2620 758611
SGTC_2125 5246583 200 µM -0.124048937572611 0.454487141969708 no 1848 0.450638263843101 2633 835267
SGTC_1312 1218-2183 165 µM -0.12416034261658 0.454443726411946 no 1849 0.450594160610123 2605 6744073
SGTC_748 act1.228 77.9 µM -0.124825823906839 0.454184393660866 no 1850 0.450330721381923 2622 4421505 YNR035C ARC35
SGTC_2322 7413319 38.22 µM -0.125661415355944 0.453858798007794 no 1851 0.449999972887022 2733 1840400
SGTC_937 3122-0005 46.7 µM -0.128739182014534 0.452659787928707 no 1852 0.448782015303955 2751 759535
SGTC_2353 9059630 146.67 µM -0.129759371505187 0.452262445900724 no 1853 0.448378403957761 2727 4779114
SGTC_3197 9113331 49.47 µM -0.130010371298707 0.452164694152013 no 1854 0.448279110613641 2781 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1919 st067113 52.3 µM -0.13026725054745 0.452064655654678 no 1855 0.448177494762893 2761 1268243
SGTC_1492 4158-0558 28.5 µM -0.130587998213254 0.451939748652766 no 1856 0.448050618728053 2750 3967268
SGTC_1949 st076024 69.1 µM -0.130671042058021 0.45190741011916 no 1857 0.448017770488623 2600 2921930
SGTC_1952 st077036 64.1 µM -0.131524033130204 0.451575260958775 no 1858 0.447680388010777 2617 2937007
SGTC_84 0443-0269 128.823 µM -0.132203006889031 0.451310897223234 no 1859 0.447411861422581 2633 6150058
SGTC_1117 retinoic acid 1.10837 µM -0.132755136170712 0.451095937289021 no 1860 0.447193518181067 2751 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_417 st075190 100 µM -0.132759284457049 0.451094322295102 no 1861 0.447191877773797 2724 222757
SGTC_1003 4049-0218 100 µM -0.13278918839446 0.451082680240102 no 1862 0.447180052523209 2768 295161
SGTC_48 0382-0018 55 µM -0.132991930596926 0.45100375074535 no 1863 0.4470998811308 2850 762596
SGTC_873 0591-4978 488 µM -0.135068280170933 0.450195519896092 no 1864 0.446278944538516 2844 3305145
SGTC_976 1348-1067 47.6 µM -0.136312465728489 0.449711312345908 no 1865 0.445787134820824 2650 5310671 YGL099W LSG1
SGTC_1203 3992-3522 103 µM -0.137358649325627 0.44930422038035 no 1866 0.445373657118219 2950 5322312
SGTC_3244 9134489 49.47 µM -0.137507010041776 0.449246494425966 no 1867 0.445315026083783 2733 16584271
SGTC_3 0833-0587 95.581 µM -0.137815590316183 0.449126431779799 no 1868 0.445193081322676 2645 5382644
SGTC_1066 ketoconazole 628 nM -0.138133382188787 0.449002789946859 no 1869 0.445067501742439 2798 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2773 thioridazine 9.09 µM -0.138222589074333 0.448968083520844 no 1870 0.445032251474955 2626 5452 An antipsychotic.
SGTC_2858 9025781 8.96 µM -0.13859469210985 0.448823319017089 no 1871 0.444885218956196 2750 4894980 YPL153C RAD53
SGTC_1634 st006576 41 µM -0.140233588844955 0.448185797198247 no 1872 0.444237717023963 2735 3915356
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.140378741965687 0.448129339858222 no 1873 0.444180376491515 2689 676296 Flavone; oxidizing agent.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.141844482105825 0.447559298952643 no 1874 0.443601423813019 2677 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1706 st031321 9.9705 µM -0.142738196541788 0.447211777599889 no 1875 0.443248474547504 2756 6103185
SGTC_861 0443-0273 110 µM -0.143319984368727 0.446985570842397 no 1876 0.443018736757444 2742 6149169
SGTC_1761 st044296 37 µM -0.144388619588829 0.446570116401695 no 1877 0.442596801447553 2643 1826700
SGTC_535 2293-4129 48.2 µM -0.145019764909988 0.446324772883848 no 1878 0.442347633305494 2780 396118 YIL048W NEO1
SGTC_1627 st003713 25.6 µM -0.146477892353608 0.445758037427569 no 1879 0.441772070509239 2753 16195070 YER133W GLC7
SGTC_397 arbidol 50 µM -0.14892607688767 0.444806742835984 no 1880 0.440805982142744 2812 131410 A RNA synthesis inhibitor.
SGTC_1134 3477-0009 42.5 µM -0.149476669444699 0.444592841871128 no 1881 0.440588758810693 2921 3973534
SGTC_381 3461-2219 42.7 µM -0.149790958282808 0.444470750309446 no 1882 0.44046477155876 2758 2883159
SGTC_1895 st058434 18.3 µM -0.151414732981413 0.443840047886105 no 1883 0.439824284107156 2806 5393175
SGTC_497 capsazepine 133 µM -0.15143872204364 0.443830731177917 no 1884 0.439814822952561 2688 2733484 A calcium channel blocker.
SGTC_840 0245-0196 390 µM -0.151706976848267 0.443726550324274 no 1885 0.439709027071016 2802 3827528
SGTC_3001 9076041 71.4286 µM -0.152162978742427 0.443549463946813 no 1886 0.439529196290052 2690 16004211
SGTC_2363 9053361 176 µM -0.15334901927022 0.443088923077267 no 1887 0.439061522995891 2812 6469797 YMR079W SEC14
SGTC_730 1436-0052 41.2 µM -0.153589308989264 0.442995627654286 no 1888 0.43896678355175 2668 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1514 1189-1591 158 µM -0.153679079184322 0.442960774088489 no 1889 0.438931390598121 2880 767698 YMR146C TIF34
SGTC_3326 9140064 16.379 µM -0.153857800653093 0.442891386220044 no 1890 0.438860929014191 2661 1868434
SGTC_708 3448-5400 146 µM -0.156046772751881 0.442041669625719 no 1891 0.437998076724175 2690 3462195
SGTC_2128 5255449 168.493 µM -0.156473452952771 0.441876071558966 no 1892 0.437829921478091 2699 736008
SGTC_2596 sinensetin 100 µM -0.1573246079583 0.441545761728728 no 1893 0.437494513699327 2746 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_696 1560-0013 611 µM -0.157991936659129 0.441286818244289 no 1894 0.437231576264718 2861 1650269
SGTC_2302 7771753 200 µM -0.158404089465979 0.441126903163847 no 1895 0.437069195768193 2745 2203047
SGTC_2438 5259590 200 µM -0.158429932736966 0.441116876307312 no 1896 0.437059014355742 2814 1201127
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.158637242754745 0.441036444054864 no 1897 0.43697734242653 2634 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_3304 9125678 46.087 µM -0.159380600138552 0.440748055875193 no 1898 0.436684511190753 2719 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2785 7756463 72.73 µM -0.159519304340389 0.440694248553458 no 1899 0.436629875194166 2712 2201551
SGTC_1557 sumaresinolic acid 42.3 µM -0.163654873662884 0.439090450420761 no 1900 0.435001422035384 2696 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1692 fluoroquinolonic acid 71 µM -0.16375790098128 0.439050508470226 no 1901 0.43496086717009 2809 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_848 0368-0089 85.6 µM -0.166515751476516 0.437981568354411 no 1902 0.433875544165174 2785 762535
SGTC_849 0386-0493 241 µM -0.166675919516794 0.437919501205428 no 1903 0.433812526953176 2705 726119
SGTC_167 3672-0051 66.205 µM -0.168234283000937 0.437315695517833 no 1904 0.43319948567971 2686 3237971
SGTC_1677 st019204 53.9 µM -0.169995643623689 0.436633412065908 no 1905 0.432506781335596 2819 3945625
SGTC_517 1365-0151 113 µM -0.170516840935648 0.436431556290135 no 1906 0.43230184557858 2870 768657
SGTC_1885 st057546 99.9 µM -0.171285544448914 0.436133873460682 no 1907 0.431999623175371 2862 702008
SGTC_576 1073-0113 22.7 µM -0.173944875654043 0.435104319250376 no 1908 0.430954392252244 2740 5439563
SGTC_1376 2910-0861 41.3 µM -0.174207970215849 0.435002486565724 no 1909 0.430851010994942 2714 1112859
SGTC_2177 5811945 192 µM -0.174623269132335 0.434841750842538 no 1910 0.430687831694775 2864 5343475
SGTC_3319 9138450 16.7555 µM -0.175802454108634 0.434385422325513 no 1911 0.430224570783812 2741 2029690
SGTC_129 0088-0017 176.636 µM -0.175843622866577 0.434369492152838 no 1912 0.430208398736738 2756 182446
SGTC_2240 6690706 185.951 µM -0.176576350495094 0.434085982440142 no 1913 0.429920585866254 2681 805876
SGTC_463 ikarugamyin 104 µM -0.177161343883371 0.433859658942327 no 1914 0.429690829216671 2702 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2640 pentamidine 10.38 µM -0.177270776676529 0.433817323753529 no 1915 0.429647852035688 2819 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_492 tmb-8 126 µM -0.178289058366558 0.433423427590494 no 1916 0.429247985654803 2784 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1717 st033143 58.0435 µM -0.17999579279312 0.432763369616898 no 1917 0.428577935560881 2857 674616
SGTC_756 0508-1999 28.3 µM -0.180857274582107 0.432430273533769 no 1918 0.428239802838942 2737 6753853
SGTC_3131 9127911 49.47 µM -0.181188849348785 0.432302081337569 no 1919 0.428109673338406 2971 45595681
SGTC_3034 9090421 49.47 µM -0.182010710510875 0.431984367200228 no 1920 0.427787160263497 2706 17173761
SGTC_2065 5221596 34.26 µM -0.182789107820007 0.431683495822095 no 1921 0.427481747662398 2859 788581
SGTC_153 4077-0274 519.67 µM -0.182869208004932 0.431652537204089 no 1922 0.42745032195142 2951 3121976
SGTC_585 0kpi-0023 191 µM -0.183512381601617 0.431403966674091 no 1923 0.427198002314669 2858 64601
SGTC_435 c-PAF 6.7 µM -0.18357758175017 0.431378769959965 no 1924 0.427172425690043 2858 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1219 1469-0211 33.1 µM -0.183795465920463 0.431294570258615 no 1925 0.427086956608768 2808 6822282
SGTC_1545 lovastatin 49.4 µM -0.183863817076718 0.431268157110734 no 1926 0.42706014531313 2773 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_896 0964-0007 44.5 µM -0.186338584591303 0.430312033018054 no 1927 0.426089625585035 2688 6756758
SGTC_3216 9129716 49.47 µM -0.186964983942691 0.430070088774341 no 1928 0.425844043778489 2782 8056934
SGTC_676 falcarinol 140 µM -0.18760907283803 0.429821339393424 no 1929 0.425591556721631 2863 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_380 3970-0968 6 µM -0.188419117827799 0.429508536746836 no 1930 0.425274057114976 2750 2891601
SGTC_1513 0337-0559 19 µM -0.188618675695318 0.429431483332748 no 1931 0.425195847230853 2757 775073
SGTC_1650 st011916 45.8 µM -0.188871575123252 0.429333837503389 no 1932 0.425096736175299 2800 242528
SGTC_3012 9080433 71.4286 µM -0.18894617061911 0.429305036606706 no 1933 0.425067503172216 2792 17688859
SGTC_1302 1159-0335 255 µM -0.189145756722332 0.429227979398252 no 1934 0.424989290004748 2726 649284
SGTC_345 1362-0200 395 µM -0.190099888065546 0.42885964087401 no 1935 0.42461542889612 2760 1419823
SGTC_415 dibenzyl ketone 100 µM -0.190386106720294 0.428749159390749 no 1936 0.424503291899234 2819 7593
SGTC_1571 st070080 73.4 µM -0.191242283330934 0.428418705342496 no 1937 0.424167888801746 2884 4315245
SGTC_2549 cedrol 20.94 µM -0.191316101034446 0.428390216652723 no 1938 0.424138973636984 2900 6708665 A sedative which affects the nervous system.
SGTC_1874 staurosporine 7.6 µM -0.191882481742349 0.428171644058549 no 1939 0.423917130001158 2871 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3157 9099274 49.47 µM -0.194688423334798 0.427089126353124 no 1940 0.422818437668498 2805 17217662
SGTC_1963 st076565 50.3 µM -0.194846291839183 0.427028237735257 no 1941 0.422756640549836 2759 4914280
SGTC_1806 st050005 60.3 µM -0.194976545859436 0.42697800111169 no 1942 0.422705654463358 2746 5194765
SGTC_2207 7258803 200 µM -0.195628174637118 0.426726697457513 no 1943 0.422450603091225 2842 3666799
SGTC_2452 5863136 48.41 µM -0.196784472167987 0.426280839235141 no 1944 0.421998101468928 2720 2184096
SGTC_804 1595-0054 20.9 µM -0.197658566207266 0.425943858703714 no 1945 0.42165610471736 2776 761523 Stimulates phospholipase C.
SGTC_1824 st053723 68.6 µM -0.198175256287172 0.425744689876446 no 1946 0.421453973083004 2788 675225
SGTC_1123 mangostin 811.285 nM -0.198733635705613 0.425529472334384 no 1947 0.421235555649717 2853 5281650 An antioxidant.
SGTC_2697 mebhydrolin 72.4 µM -0.198825476122474 0.425494076181317 no 1948 0.421199633385298 2879 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2006 4011487 200 µM -0.200282271447078 0.424932694167103 no 1949 0.420629913490924 2899 45595294
SGTC_579 4491-1009 110 µM -0.202217281208569 0.424187265793024 no 1950 0.419873431875324 2797 1271041
SGTC_606 k015-0008 38.6 µM -0.202893887509833 0.423926678992706 no 1951 0.41960898599065 2900 1970475
SGTC_2907 7721985 69.9 µM -0.202904701500597 0.423922514383627 no 1952 0.419604759727689 2821 3267881
SGTC_700 3453-2283 142 µM -0.203229391866228 0.423797475842579 no 1953 0.419477870389099 2953 565664
SGTC_1477 0139-0234 16 µM -0.204759660758662 0.423208271454636 no 1954 0.418879952619458 2757 620880
SGTC_2364 9055074 200 µM -0.205993520942438 0.422733319241391 no 1955 0.418397986158388 2857 6470630
SGTC_1891 st059073 26.2 µM -0.207743145701991 0.422060025438554 no 1956 0.417714763565015 2965 688754
SGTC_3257 9139206 32.98 µM -0.20871183864648 0.421687349062815 no 1957 0.417336598882768 2878 4910041
SGTC_1958 st076513 41.9 µM -0.209421988645264 0.421414184081194 no 1958 0.417059414431642 2762 732122 YGL099W LSG1
SGTC_2158 5657123 3.6195 µM -0.209896933807557 0.42123151365148 no 1959 0.416874057697209 2744 2858827
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.21013108254846 0.421141463068132 no 1960 0.416782683321935 2904 6708760
SGTC_3026 9090633 49.47 µM -0.210269020437148 0.421088415867219 no 1961 0.416728856443742 2764 25236842
SGTC_1317 1273-0028 910 nM -0.210693136126021 0.420925321361388 no 1962 0.416563365481154 2808 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_137 0438-0332 85.389 µM -0.211393610778396 0.420655982210672 no 1963 0.41629007097944 2772 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1222 0366-0074 1.18 µM -0.212847312257333 0.4200971388529 no 1964 0.415723029665933 2928 286520
SGTC_2202 7226349 200 µM -0.213946151113638 0.419674821394755 no 1965 0.41529452498914 2768 844334
SGTC_186 3455-3465 67.277 µM -0.21447513845014 0.419471548296491 no 1966 0.415088276263081 2769 755278
SGTC_1695 st026914 34.495 µM -0.216121010135597 0.418839229550492 no 1967 0.41444671148914 2760 3289191
SGTC_2184 6075246 200 µM -0.216241774386553 0.418792842005672 no 1968 0.414399646256171 2850 2267320
SGTC_2504 purpurogallin 52.29 µM -0.218106994768645 0.418076523802252 no 1969 0.41367287378107 2774 5281571 An antioxidant.
SGTC_2219 9098279 200 µM -0.218219956599417 0.41803315070414 no 1970 0.413628868317595 2801 902349
SGTC_1583 clindamycin 39.6 µM -0.221139603998931 0.416912463141413 no 1971 0.412491866991342 2784 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1100 amiodarone 5.07 µM -0.222152356038639 0.416523882070565 no 1972 0.412097640871841 2912 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_603 3794-0023 45.9 µM -0.222535951968756 0.416376722090738 no 1973 0.411948344600075 2888 3802260
SGTC_256 clotrimazole 625 nM -0.225335308248297 0.415303153345801 no 1974 0.410859216939934 2830 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_163 TUB2.036 7.546 µM -0.228041640995677 0.414265860373311 no 1975 0.409806934209116 2892 15992207 YJR013W GPI14
SGTC_2115 tiliquinol 12.7705 µM -0.228343146500753 0.414150335129097 no 1976 0.409689742181171 2921 71208 A bioactive hydroxyquinoline.
SGTC_125 0133-0007 11.75 µM -0.230464017204574 0.413337909970284 no 1977 0.408865610536374 2929 26541
SGTC_2259 7964009 200 µM -0.23059397483114 0.413288140156006 no 1978 0.408815124433643 2962 313134
SGTC_3347 9188721 44.724 µM -0.230753818683299 0.413226926738183 no 1979 0.408753030167181 2893 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_761 k216-0224 480 µM -0.231109372993245 0.413090772079915 no 1980 0.40861491681108 2990 1340404
SGTC_2418 pentamidine 31.67 µM -0.231254309775644 0.413035273520135 no 1981 0.408558620072286 2776 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2239 6685329 187.64 µM -0.231524968499742 0.412931638717453 no 1982 0.408453495128037 2950 805680
SGTC_2043 5101342 149 µM -0.231869450728227 0.412799745787177 no 1983 0.408319706364267 2843 678451
SGTC_1820 st053765 18.6 µM -0.231901570217666 0.412787448604677 no 1984 0.408307232457358 2873 3690829
SGTC_2017 5132927 60.65 µM -0.232613817996292 0.412514781323407 no 1985 0.408030648205437 2822 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_3263 9137018 49.47 µM -0.232797353416137 0.412444525947406 no 1986 0.407959384069883 2868 43844957
SGTC_1434 4073-0095 163 µM -0.234026576796028 0.411974064933012 no 1987 0.407482173096637 2838 24133745
SGTC_635 k038-0028 24.7 µM -0.235177408330363 0.41153372148202 no 1988 0.407035519920745 2866 4035102
SGTC_1341 1486-1360 280 µM -0.236638512782319 0.410974818666969 no 1989 0.406468619874713 2807 3976547
SGTC_3175 9106517 49.47 µM -0.237626245627621 0.410597092609895 no 1990 0.406085496215343 2913 41468073
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.239979699772445 0.409697425916995 no 1991 0.405172997026863 2848 688669
SGTC_362 0310-0100 9.03 µM -0.240250666984231 0.409593872345827 no 1992 0.405067968537869 2967 790235
SGTC_1238 0333-0287 48.8 µM -0.240912461368599 0.409340985718031 no 1993 0.404811481888208 2826 7226
SGTC_3075 9116269 49.47 µM -0.241591986898948 0.409081362868764 no 1994 0.404548165860783 3039 17015205 YNL244C SUI1
SGTC_889 0919-1524 82.7 µM -0.241688276790179 0.409044577105021 no 1995 0.404510857038112 2903 3905452
SGTC_2378 9074213 121.43 µM -0.242121542359452 0.40887906596089 no 1996 0.4043429931719 2835 657714
SGTC_1010 4112-3296 15.2 µM -0.242550138923823 0.408715354401558 no 1997 0.404176955583838 2985 704384
SGTC_3047 9092122 49.47 µM -0.243563859762016 0.408328205631529 no 1998 0.40378431057715 2899 17173831
SGTC_3236 9132701 49.47 µM -0.24424878834938 0.408066676089205 no 1999 0.40351907168976 2882 24282524
SGTC_3208 9114115 49.47 µM -0.247483052857466 0.406832276603741 no 2000 0.402267202758879 2917 650895
SGTC_471 1-acyl-paf 4 µM -0.247820005207693 0.406703727315018 no 2001 0.40213683787096 2839 16759367
SGTC_749 1000-0129 128 µM -0.248208035201211 0.406555704061497 no 2002 0.401986724829003 3000 708470
SGTC_1587 estradiol valerate 56.1 µM -0.248560163890996 0.406421387767534 no 2003 0.40185051305502 3015 13791 A steroid.
SGTC_9 0092-0002 10.449 µM -0.248567565835185 0.406418564481177 no 2004 0.401847649934379 2895 759368
SGTC_1353 1498-1206 8.11 µM -0.252424276508984 0.404948183712474 no 2005 0.400356568806834 2860 6756808
SGTC_541 4513-1321 94 µM -0.252540866360982 0.404903754312274 no 2006 0.400311515338063 2868 747515
SGTC_670 4204-0025 119 µM -0.252720057379934 0.404835471604063 no 2007 0.40024227367338 2960 719039
SGTC_669 0108-0021 26.2 µM -0.253346518442709 0.40459677451318 no 2008 0.400000225891827 2929 17201
SGTC_2915 7971052 15.16 µM -0.253478159514542 0.40454662053419 no 2009 0.399949368187313 2862 5741558
SGTC_1796 st049173 110.4 µM -0.253579025060702 0.404508192794927 no 2010 0.399910401329052 2917 94134
SGTC_732 3970-1727 52.7 µM -0.253714992853231 0.404456393265413 no 2011 0.399857875181115 2971 1275699
SGTC_3351 9150312 21.596 µM -0.25616408728393 0.403523651528701 no 2012 0.398912068907174 2891 4904905
SGTC_1800 st050079 29.0735 µM -0.256659194061873 0.403335155756465 no 2013 0.39872093745075 2961 3645560
SGTC_2390 9097792 176.6 µM -0.256820547733137 0.403273730453504 no 2014 0.39865865358243 2860 4497149
SGTC_115 0527-0192 112.043 µM -0.257628599862741 0.402966151152467 no 2015 0.398346777550909 2939 4233931
SGTC_2349 9023730 187.07 µM -0.25771328025078 0.402933921636603 no 2016 0.398314098038866 3003 4126287
SGTC_1007 4101-0031 70 µM -0.25915109915439 0.402386785878439 no 2017 0.397759329831496 3031 1146276
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.259502250907865 0.402253190488391 no 2018 0.39762387275982 2841 1241132 A phosphatase inhibitor.
SGTC_1741 st038134 10.228 µM -0.25955341954643 0.402233724375442 no 2019 0.397604135446243 3098 1272587
SGTC_1211 1056-0033 32.3 µM -0.259671517859932 0.402188797095607 no 2020 0.397558582304622 2982 6741922
SGTC_934 2950-0684 338 µM -0.260491804525422 0.401876777112226 no 2021 0.397242218106185 3081 1121253
SGTC_2774 tamoxifen 10.92 µM -0.260889528164338 0.401725513811141 no 2022 0.397088850293879 2827 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2258 7960471 200 µM -0.260960352797471 0.40169857914386 no 2023 0.397061540990695 2935 2974708
SGTC_327 1273-0057 3.96 µM -0.261951751971846 0.401321598280527 no 2024 0.396679319963013 2910 3108138
SGTC_298 1391-0729 10 µM -0.263388139212864 0.400775573111342 no 2025 0.396125715748994 2875 3237558
SGTC_3240 9133527 49.47 µM -0.263796580461207 0.400620344473371 no 2026 0.395968334834269 2904 17617455
SGTC_3065 9113888 49.47 µM -0.264802066738042 0.400238274997733 no 2027 0.39558097234384 3071 16648368
SGTC_2068 5226020 147 µM -0.265473696492255 0.399983119070425 no 2028 0.395322285138906 2915 1810509
SGTC_3125 9127534 49.47 µM -0.266074303462606 0.399754981255861 no 2029 0.395090992370344 2896 1639235
SGTC_2581 avocatin a 64 µM -0.266178502623049 0.39971540516157 no 2030 0.395050869202978 2920 6710728 A skin care supplement.
SGTC_664 1222-0054 14.9 µM -0.266838958221973 0.399464580158405 no 2031 0.394796578554927 2896 6813991
SGTC_430 0958-0115 16.4 µM -0.267249133314761 0.399308826494006 no 2032 0.3946386742281 2908 6833180
SGTC_1989 st071868 50.2 µM -0.26737702851462 0.399260264788387 no 2033 0.394589442194454 3022 16414057
SGTC_2648 atorvastatin 78.68 µM -0.271507570047424 0.397692743621965 no 2034 0.393000339122595 2987 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2667 digitoxin 100 µM -0.272163947454655 0.397443802787364 no 2035 0.392747980785588 2972 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.27228841463372 0.397396601477559 no 2036 0.392700131797094 3018 521171
SGTC_2794 7785382 27.27 µM -0.272359250040677 0.39736973945239 no 2037 0.392672901225285 2924 2205081
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.272631989065177 0.397266316590433 no 2038 0.392568059701121 2904 688664
SGTC_1962 st076595 64.5 µM -0.272778699439885 0.397210686883106 no 2039 0.392511667111127 2881 279619
SGTC_574 1315-0397 40 µM -0.273096630273557 0.397090140900511 no 2040 0.39238946848139 2889 6794277
SGTC_1282 0886-0010 32.4 µM -0.273556172169077 0.396915919344262 no 2041 0.392212859541028 3049 2836211 YNL267W PIK1
SGTC_2966 9084041 48.03 µM -0.273566089872487 0.396912159570498 no 2042 0.392209048261358 2817 17741380
SGTC_980 1473-0395 201 µM -0.273709070775093 0.396857956973225 no 2043 0.392154103201383 2870 768876
SGTC_2354 9060492 162 µM -0.274655273731628 0.396499311384826 no 2044 0.391790548202812 3035 6471895
SGTC_774 k060-0086 136 µM -0.274856084218083 0.39642320810532 no 2045 0.391713403899766 3030 5911235
SGTC_1506 4226-2149 212 µM -0.275618116850167 0.396134448441624 no 2046 0.391420696611736 2998 991114
SGTC_2842 9000675 19.48 µM -0.275867548818474 0.396039942692136 no 2047 0.391324899683956 2952 2989072
SGTC_2114 5491910 81.25 µM -0.277240543460401 0.395519846688867 no 2048 0.390797705038091 3011 2849228
SGTC_1195 1502-0147 41.1 µM -0.277533317785112 0.39540896660431 no 2049 0.390685313146243 2901 817940
SGTC_3006 9075424 71.4286 µM -0.27765648550896 0.395362322804312 no 2050 0.390638033540394 2928 7465181
SGTC_1441 4106-0040 13 µM -0.278287927436617 0.395123218363737 no 2051 0.390395671375675 2893 2904180
SGTC_1618 st003135 44.5 µM -0.279542931496244 0.394648110586472 no 2052 0.389914098012136 2852 1270615
SGTC_943 3253-1379 105 µM -0.279888939605776 0.394517149569449 no 2053 0.389781356572573 3078 668464
SGTC_438 sphingosine 6.67 µM -0.28188881254479 0.393760449312729 no 2054 0.389014384062427 2878 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2679 rapamycin 1 nM -0.281957247124579 0.393734562515103 no 2055 0.388988146307044 2978 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2211 7117706 200 µM -0.283186894090836 0.39326950320687 no 2056 0.388516787166865 3002 822771
SGTC_1574 spiramycin 23.7 µM -0.283605274050876 0.393111304265223 no 2057 0.388356447448391 2869 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_3132 9126706 49.47 µM -0.283739160139744 0.393060682628343 no 2058 0.388305141030057 3116 850858
SGTC_2048 5246248 200 µM -0.284322174856707 0.392840268875187 no 2059 0.388081746997742 3034 677046
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.284539644232085 0.392758061492115 no 2060 0.387998428629532 2844 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_818 4072-2707 53.5 µM -0.285249536925744 0.392489742442615 no 2061 0.387726485542228 2859 882871
SGTC_1232 0279-0259 161 µM -0.287711709729568 0.391559508541831 no 2062 0.386783712899273 2951 1560000
SGTC_2205 7238770 200 µM -0.288331823947995 0.39132532058246 no 2063 0.386546374523832 3040 279867
SGTC_2944 9067346 25.62 µM -0.288579673337126 0.3912317305444 no 2064 0.38645152616772 3084 6473075
SGTC_2037 5169046 200 µM -0.288657129580013 0.391202483699355 no 2065 0.386421886181226 3021 5718022
SGTC_769 0302-0231 76 µM -0.289658752469501 0.390824334542565 no 2066 0.386038657410268 3005 571869 YER009W NTF2
SGTC_2772 vinpocetine 57.06 µM -0.29047607507282 0.390515841919448 no 2067 0.385726025726254 3121 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.290860701217106 0.390370691340202 no 2068 0.385578929170366 2904 23665772 A membrane-active detergent.
SGTC_1338 1486-1223 76 µM -0.290920233069069 0.390348226518413 no 2069 0.385556163258328 2990 3444526
SGTC_2097 5376186 200 µM -0.291094631104191 0.390282418128638 no 2070 0.385489472989491 3052 742755
SGTC_1008 4106-0037 6 µM -0.291383014722716 0.390173604640267 no 2071 0.38537920176147 2869 2905394
SGTC_1784 st039334 36.3 µM -0.291732270444954 0.390041834287736 no 2072 0.385245666855042 3162 3496984
SGTC_1567 st069303 68.4 µM -0.292870023045448 0.389612660404688 no 2073 0.384810751411377 3024 5581319
SGTC_3060 1327-0027 12.5 µM -0.293034966983999 0.389550452736205 no 2074 0.384747712225354 2989 16000455 YPR107C YTH1
SGTC_2591 skatole 100 µM -0.293922033274712 0.389215949299296 no 2075 0.384408740622257 3051 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1261 0712-0010 12.7 µM -0.294823385730667 0.388876142774349 no 2076 0.384064400411288 3107 2840123
SGTC_3021 9087658 49.47 µM -0.294998097317567 0.388810286981682 no 2077 0.383997666593857 3008 25237042
SGTC_595 3909-8003 73.7 µM -0.295980496668655 0.388440040874376 no 2078 0.38362248792431 3057 699517
SGTC_1370 2001-0092 44.6 µM -0.296000304005482 0.388432576937692 no 2079 0.383614924615829 3154 790957
SGTC_451 chloral hydrate 100 µM -0.297731894054063 0.387780226803216 no 2080 0.382953899403986 3054 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_483 fpl-64176 144 µM -0.298071190842282 0.387652438955199 no 2081 0.382824414538721 2932 3423
SGTC_919 tnp00227 403.569 nM -0.298180266595716 0.387611360820939 no 2082 0.382782791050952 2953 1269246 A methoxyflavone. YNL221C POP1
SGTC_288 1315-0019 35.1 µM -0.299011442280464 0.387298379841194 no 2083 0.382465657530742 3024 6811474
SGTC_412 gemfibrozil 100 µM -0.300473983748728 0.386747834667647 no 2084 0.381907819043137 2989 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_957 1187-1561 14.1 µM -0.301424136799912 0.386390290118212 no 2085 0.381545545582679 2939 1538454
SGTC_1697 st025554 27.742 µM -0.302063911592192 0.386149595857977 no 2086 0.38130167127732 2916 1269519
SGTC_3152 9099253 49.47 µM -0.304546635858949 0.385215968040266 no 2087 0.380355734325248 3013 25236131
SGTC_1430 4049-0248 69.1 µM -0.307437666129209 0.384129635050001 no 2088 0.379255131022599 3072 22774488
SGTC_1329 1447-1697 50.6 µM -0.309311882375133 0.383425865347373 no 2089 0.378542146521565 3038 2840515
SGTC_1744 st037937 38.9 µM -0.309611429898694 0.383313420586765 no 2090 0.37842823166622 3144 1016152
SGTC_2327 6189656 200 µM -0.310488407892628 0.382984275342153 no 2091 0.378094786690517 3067 5349088
SGTC_2665 lovastatin 100 µM -0.311147178300201 0.382737082783407 no 2092 0.377844368400734 2978 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2666 tannic acid 100 µM -0.311408910343316 0.382638885470606 no 2093 0.377744890481928 3028 16134267 A thiamine antagonist.
SGTC_1275 0867-0008 21.1 µM -0.312146313297213 0.382362265291955 no 2094 0.377464665356826 2922 3422836
SGTC_3032 9089427 49.47 µM -0.312393173552985 0.382269674607015 no 2095 0.377370868844003 3062 17173707
SGTC_2730 imipramine 71.33 µM -0.31256497151412 0.382205241754961 no 2096 0.377305597113707 2973 3696 A tricyclic antidepressant.
SGTC_416 estradiol valerate 100 µM -0.313349360832251 0.381911097889492 no 2097 0.377007626215091 3028 13791 A steroid.
SGTC_96 0929-0093 37.281 µM -0.313680128460943 0.381787081347454 no 2098 0.376881997378818 2961 6991579
SGTC_1127 asiatic acid 681.4 nM -0.31442633773861 0.381507345537774 no 2099 0.37659862756046 2941 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2089 5281248 129.67 µM -0.315068578632529 0.38126663450403 no 2100 0.376354792521315 2973 2737878
SGTC_1076 itraconazole 331 nM -0.315886556163227 0.380960124118751 no 2101 0.376044308244577 2976 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_992 3909-8734 162 µM -0.316877914821985 0.380588744929633 no 2102 0.375668120268314 3005 4288319
SGTC_2991 9074669 71.4286 µM -0.316989708758903 0.380546871986439 no 2103 0.375625705556722 3152 17333109
SGTC_456 gingerol 170 µM -0.31871347650823 0.379901404121187 no 2104 0.374971897207828 3157 442793 A herb.
SGTC_2182 6325192 200 µM -0.31924118334137 0.379703870147186 no 2105 0.374771814848763 3000 736248
SGTC_2306 7482397 179.52 µM -0.319255183444463 0.379698629982772 no 2106 0.374766507107032 3138 891448
SGTC_292 k038-0015 474 µM -0.319414690745495 0.379638928805073 no 2107 0.374706036116149 3084 46368540
SGTC_1185 1319-0113 81.3 µM -0.319633396006238 0.379557075387924 no 2108 0.374623127529112 3064 4672763
SGTC_393 acivicin 6.25 µM -0.321431848918977 0.378884184929815 no 2109 0.373941575327558 2955 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1835 st008666 49.2 µM -0.322121585617907 0.378626217442948 no 2110 0.373680293075073 2956 690455
SGTC_2823 7987624 58.44 µM -0.322384252817791 0.378527991850551 no 2111 0.373580806190369 3203 2239440
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.323131183017897 0.378248716816125 no 2112 0.373297947650313 2999 65057 A dermal irritant. YDR527W RBA50
SGTC_793 0488-0545 106 µM -0.324452842523031 0.37775470806556 no 2113 0.372797609487872 2968 292548
SGTC_2479 5617353 43.85 µM -0.325227186910019 0.377465367091527 no 2114 0.372504566988975 3142 2731746
SGTC_218 alverine citrate 93.75 µM -0.325331137370901 0.377426530267427 no 2115 0.372465233643373 3105 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1196 1588-0294 184 µM -0.326240491797245 0.377086840189057 no 2116 0.372121203883924 3030 6144269
SGTC_1803 st050068 52.4 µM -0.326828162471441 0.376867365906382 no 2117 0.371898928777314 3063 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2218 6965428 192.983 µM -0.327142330093391 0.3767500516877 no 2118 0.371780118435099 3063 675684
SGTC_716 1683-5115 658 µM -0.327308977244342 0.376687828122995 no 2119 0.371717101603424 2970 723597
SGTC_2724 maprotiline 69.64 µM -0.327868174346818 0.376479055669692 no 2120 0.371505668991701 3106 4011 A tricyclic antidepressant.
SGTC_269 exalamide 29 µM -0.328048711643588 0.376411661003682 no 2121 0.371437416053605 2992 3316 A derivative of salicylamide.
SGTC_2678 equilin 100 µM -0.32863580779375 0.376192523764442 no 2122 0.371215489665918 3084 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_3151 9099821 49.47 µM -0.330094124235656 0.375648371025498 no 2123 0.370664421411752 3101 17174189
SGTC_2019 4016004 108 µM -0.330607017314286 0.375457050033904 no 2124 0.370470672489248 3065 45595336
SGTC_2715 st079500 56.4 µM -0.331458471197982 0.375139505666871 no 2125 0.370149102427707 2954 28246688
SGTC_2401 5128683 200 µM -0.33171654623032 0.375043274906085 no 2126 0.370051652694129 3005 708373
SGTC_1529 apigenin 74 µM -0.334029635976777 0.374181120229604 no 2127 0.369178597756516 3226 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1616 st002734 56.1 µM -0.334344610011041 0.374063768956291 no 2128 0.369059765706591 2988 4026101
SGTC_2880 9042983 58.44 µM -0.335235246543225 0.373732003738454 no 2129 0.368723817936675 3118 6464714
SGTC_119 0121-0043 24.815 µM -0.338077108328424 0.372674026801226 no 2130 0.367652540424317 3022 1092378
SGTC_1181 1222-0449 220 µM -0.338235636979446 0.372615037466323 no 2131 0.367592811168939 3179 658318
SGTC_2141 5621638 7.665 µM -0.338348594856226 0.372573007076146 no 2132 0.367550253687531 3126 2856238
SGTC_1239 0337-0584 35.4 µM -0.338669694958279 0.372453537529926 no 2133 0.367429286399606 3168 914301 YML130C ERO1
SGTC_2110 5483698 200 µM -0.339472833767077 0.372154772855551 no 2134 0.367126779422015 3045 2848765 YHR062C RPP1
SGTC_2235 salicylic acid 500 µM -0.341312283243314 0.371470794613998 no 2135 0.366434250914471 3053 338 A COX inhibitor and kinase inhibitor.
SGTC_16 erodoxin 22.806 µM -0.341889869912333 0.371256109199163 no 2136 0.366216886708732 3117 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_796 1234-0020 70.7 µM -0.342025559777201 0.37120567991795 no 2137 0.366165828526885 3003 46495034
SGTC_2200 6600604 21.907 µM -0.343214214513525 0.370764009752413 no 2138 0.36571865590702 3005 2904777
SGTC_791 1348-1292 225 µM -0.343251942983105 0.370749993714691 no 2139 0.365704465417838 3058 5437054
SGTC_448 monastrol 171 µM -0.343587644067834 0.370625289105777 no 2140 0.365578209111186 3055 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_276 colchicine 750 µM -0.343907338032528 0.370506543378452 no 2141 0.365457986577585 3152 2833 A microtubule depolymerizer.
SGTC_46 0329-0187a 2.197 µM -0.346730166433002 0.369458580900976 no 2142 0.364397022485872 3103 46494817
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.347428380879526 0.369199521097675 no 2143 0.36413475741233 2963 6312947
SGTC_2095 5432005 200 µM -0.347431328177804 0.369198427681924 no 2144 0.364133650475456 3015 783734
SGTC_3343 9148379 18.9835 µM -0.349719250705114 0.368349953102794 no 2145 0.363274702461865 3176 1955036
SGTC_2552 juarezic acid 87.02 µM -0.350157252965876 0.368187593296623 no 2146 0.363110342790973 2991 1549512
SGTC_221 trifluoperazine 10.304 µM -0.351403390738039 0.367725800576654 no 2147 0.362642869480244 3055 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2034 5197015 53.07 µM -0.351639075438749 0.367638482208141 no 2148 0.36255447824871 3182 780676
SGTC_1198 1612-1005 86.7 µM -0.352411601299469 0.367352318584877 no 2149 0.36226480139317 3204 6998509
SGTC_3024 9090631 49.47 µM -0.353234254577335 0.367047667444289 no 2150 0.361956414773577 3158 25236383
SGTC_3289 9119912 71.43 µM -0.353400522318212 0.366986104087431 no 2151 0.361894097150316 3132 17014829
SGTC_128 0906-2981 13.371 µM -0.354464997095736 0.366592045957658 no 2152 0.361495215795566 3196 6740226
SGTC_1098 clofazimine 15.1 µM -0.355568672532873 0.366183624568424 no 2153 0.361081804015895 3152 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1103 duloxetine 36.1 µM -0.356515247858524 0.365833459677941 no 2154 0.360727367571921 3186 60835 A selective serotonin reuptake inhibitor.
SGTC_3007 9078383 71.4286 µM -0.356834007862635 0.365715566505435 no 2155 0.360608037716899 3044 6496995
SGTC_2852 9023854 51.95 µM -0.35858353036457 0.365068732872891 no 2156 0.359953334684301 3198 19798528
SGTC_1759 st043059 70 µM -0.360225633311919 0.364461963470225 no 2157 0.359339203520848 3012 669426
SGTC_1881 5652484 16 µM -0.361758657913227 0.363895805667569 no 2158 0.358766194394671 3171 2255129
SGTC_1848 st056003 16.4 µM -0.362982475240467 0.363444053599642 no 2159 0.358308987776019 3142 146492
SGTC_1630 st005209 31.3 µM -0.363357799588491 0.363305546789098 no 2160 0.358168810795958 3155 3367314
SGTC_2876 9059903 25.97 µM -0.363631377466507 0.363204598972759 no 2161 0.358066646359901 3112 6916095
SGTC_1931 st074438 57.1 µM -0.363707849772458 0.363176383067341 no 2162 0.358038090495183 3065 2787313
SGTC_2539 epi(13)torulosol 80 µM -0.364524511404331 0.362875106626647 no 2163 0.357733186793061 3143 6708597
SGTC_1451 4152-0210 104 µM -0.364735214560195 0.362797389424837 no 2164 0.35765453469576 3198 659563
SGTC_2642 cholecalciferol 100 µM -0.364738512280167 0.36279617311602 no 2165 0.357653303757996 3137 9821465 A vitamin D precursor, similar to steriods.
SGTC_3226 9131256 49.47 µM -0.365697445226526 0.362442545521712 no 2166 0.357295426347258 3090 17178073
SGTC_1288 0973-0013 65.5 µM -0.366005308446858 0.362329039061834 no 2167 0.357180557221559 3166 4315430
SGTC_3312 9133330 71.43 µM -0.366541277673876 0.362131460804815 no 2168 0.356980608660058 3198 17617324
SGTC_1056 3448-1962 115 µM -0.36656648542489 0.362122169191098 no 2169 0.356971205628722 3120 715507
SGTC_1325 1431-0015 227 µM -0.367010862558963 0.361958384477966 no 2170 0.356805457705907 3051 1103340
SGTC_3199 9111318 49.47 µM -0.367491311801082 0.361781333055099 no 2171 0.356626285683169 3155 8548020
SGTC_1667 st014849 34.6 µM -0.367569456621993 0.361752538528755 no 2172 0.356597146436204 3055 5348460
SGTC_2994 9053520 71.4286 µM -0.367924563745819 0.361621699777926 no 2173 0.356464741883127 3168 4647384
SGTC_1818 st052136 56.3 µM -0.36875614643344 0.361315367557838 no 2174 0.356154747285317 3156 674169
SGTC_1850 st056238 17 µM -0.369126478151507 0.361178976122843 no 2175 0.356016726850137 3061 5393177
SGTC_1622 st003707 19.4 µM -0.372260793104417 0.360025330845748 no 2176 0.354849343417099 3175 10140899
SGTC_1927 st060202 13.8 µM -0.372594417924581 0.359902608599208 no 2177 0.354725164007589 3178 688887
SGTC_981 1488-1094 54.9 µM -0.374652049383239 0.359146038616947 no 2178 0.353959628975607 3011 3449522
SGTC_390 dec-rvkr-cmk 16.7 µM -0.37669794366792 0.358394331538629 no 2179 0.353199045597643 3128 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_3108 9121785 49.47 µM -0.37676561232312 0.358369477922999 no 2180 0.353173899037149 3083 17140271
SGTC_622 1348-1566 26.3 µM -0.376842916849871 0.35834108593996 no 2181 0.353145172444861 3137 7340407
SGTC_302 1094-0063 18.9 µM -0.378355774916687 0.357785609529115 no 2182 0.352583158505735 3047 5440289
SGTC_1768 st044301 37.178 µM -0.381607436803962 0.356592716306599 no 2183 0.351376283601281 3118 3931349
SGTC_1201 1889-3372 45.9 µM -0.381995185376537 0.356450561526213 no 2184 0.351232467923879 3080 5392199
SGTC_419 nsc-638432 893 µM -0.382112210798489 0.356407662065931 no 2185 0.351189067459326 3144 368090
SGTC_1151 3909-8316 15.3 µM -0.382295109628532 0.356340618212531 no 2186 0.351121240835115 3188 800431
SGTC_1472 k841-0093 193 µM -0.383088842312842 0.356049717038885 no 2187 0.350826946147229 3211 X1472
SGTC_208 k072-0098 12.366 µM -0.383930932745304 0.355741184450301 no 2188 0.35051481952838 3094 5948901
SGTC_1781 st038725 66.3 µM -0.384110616489589 0.355675362544378 no 2189 0.350448231565919 3065 4270275 YIL048W NEO1
SGTC_2740 felodipine 17.08 µM -0.384170535666153 0.355653413856023 no 2190 0.350426027485549 3147 3333 L-type calcium channel blocker
SGTC_951 1171-0579 82.7 µM -0.384441325420215 0.355554228210188 no 2191 0.350325688064959 3059 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1531 st059297 52.4 µM -0.385055243287188 0.355329396849616 no 2192 0.350098243398531 3199 7566702
SGTC_3219 9131112 49.47 µM -0.385717221745173 0.355087020964604 no 2193 0.349853053454546 3186 17612988 YMR079W SEC14
SGTC_301 4119-0100 24.5 µM -0.390192228669846 0.353450090098334 no 2194 0.348197203867581 3116 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_102 gallobenzophenone 83.616 µM -0.392224163044437 0.352707712324284 no 2195 0.347446296043207 3269 70837
SGTC_1468 k284-1086 134 µM -0.393556641159384 0.352221188651171 no 2196 0.346954199116764 3128 15996457
SGTC_614 0462-0418 107 µM -0.396245386959859 0.351240191872911 no 2197 0.345962005837983 3123 5188303
SGTC_995 3931-2021 34.6 µM -0.396928116426131 0.35099125342779 no 2198 0.345710234922255 3184 730143
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.397560498349876 0.35076072986001 no 2199 0.345477091583027 3086 16623 A steroid.
SGTC_1337 1486-1011 40.3 µM -0.397993113764851 0.35060305925366 no 2200 0.345317630896447 3186 X1337
SGTC_2848 9016370 25.97 µM -0.398069246513068 0.350575314645962 no 2201 0.345289571444022 3242 7894410
SGTC_1974 st069448 26.9 µM -0.399134401221362 0.35018723025107 no 2202 0.344897087725992 3235 6323587 YNR016C ACC1
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.401524195092701 0.349317089009667 no 2203 0.344017114142386 3086 2333 A French combination drug.
SGTC_825 1988-2224 89.6 µM -0.403317406840666 0.348664687037387 no 2204 0.343357368963652 3107 1180859
SGTC_1054 3429-0080 167 µM -0.404099442634425 0.348380308612814 no 2205 0.343069797410174 3268 1162877
SGTC_2536 dehydroabietamide 32.04 µM -0.404756631617348 0.348141395191532 no 2206 0.342828204998846 3256 3983547
SGTC_3344 9148862 3.898 µM -0.40689550262895 0.347364251090306 no 2207 0.342042369632176 3262 4905352
SGTC_2515 chrysin 20.77 µM -0.407051061136825 0.347307754949975 no 2208 0.341985243037913 3192 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_421 streptovitacin 30 mM -0.407349005215714 0.347199556322946 no 2209 0.341875837518065 3268 91467 include heat shock
SGTC_1998 st075797 76.8 µM -0.407655982434303 0.347088090329331 no 2210 0.341763128903002 3241 24208315
SGTC_2862 9027634 71.43 µM -0.408508222574493 0.346778704178852 no 2211 0.341450297535876 3083 5012562
SGTC_3153 9100258 49.47 µM -0.409663889186117 0.346359329233549 no 2212 0.341026261547748 3119 25236848
SGTC_1942 st076330 65.2 µM -0.410276709465394 0.346137021846833 no 2213 0.340801487572847 3260 24208414
SGTC_846 0335-0850 148 µM -0.410369950028789 0.346103202437769 no 2214 0.340767293179083 3197 6819598
SGTC_1186 1319-0216 26 µM -0.410474341450236 0.34606533994246 no 2215 0.340729010949859 3267 4565136
SGTC_813 k007-0158 173 µM -0.411173226808913 0.345811895706113 no 2216 0.340472759271469 3174 6523916
SGTC_159 3970-0959 50 µM -0.411836660895003 0.345571371447117 no 2217 0.34022957419178 3291 6615653
SGTC_713 1488-1073 324 µM -0.412163716930408 0.345452822071418 no 2218 0.340109714610265 3170 3312542
SGTC_1402 3909-7673 35.9 µM -0.412506876458884 0.345328451890927 no 2219 0.339983970785453 3124 5328014
SGTC_1812 st052057 4.327 µM -0.412939400571465 0.34517171738802 no 2220 0.339825506483727 3097 3645418
SGTC_1765 st044815 90.4 µM -0.413684362473163 0.34490182653466 no 2221 0.339552640391461 3217 645695
SGTC_1062 mesoridazine 14.2 µM -0.414122806128577 0.34474302047486 no 2222 0.339392085693586 3153 4078 A neuroleptic.
SGTC_2103 5378138 10 µM -0.415042949360934 0.344409829850954 no 2223 0.339055231121091 3222 244142
SGTC_3168 9103419 49.47 µM -0.415660287577644 0.344186354786989 no 2224 0.338829302298107 3202 16649256
SGTC_2489 cantharidin 73.42 µM -0.41669712969117 0.343811142685336 no 2225 0.338449977048846 3176 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1053 3366-3204 134 µM -0.419533087734707 0.342785653557333 no 2226 0.337413289187313 3164 3632071 YPR165W RHO1
SGTC_763 3453-1109 128 µM -0.419540190719707 0.342783086551086 no 2227 0.337410694227347 3297 1560353
SGTC_55 0767-0285 6.563 µM -0.421000157736327 0.342255611278636 no 2228 0.336877483339941 3241 3116166
SGTC_245 methotrexate 289.6 µM -0.422371786526499 0.341760332160196 no 2229 0.33637683392609 3222 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_680 0417-1641 114 µM -0.422675816719995 0.341650587244501 no 2230 0.336265901049904 3101 2835990
SGTC_3225 9130819 49.47 µM -0.423636092850889 0.341304047027185 no 2231 0.335915614394866 3267 4547121
SGTC_1770 st043884 66.3 µM -0.423926210306152 0.341199377019356 no 2232 0.335809814228611 3137 670149
SGTC_515 4092-1064 102 µM -0.424982921449737 0.340818234899273 no 2233 0.335424562385478 3347 717353
SGTC_3027 9089541 49.47 µM -0.425213833567222 0.340734969480572 no 2234 0.335340400315532 3245 9943819
SGTC_1495 4469-0029 237 µM -0.426684900041397 0.340204694735195 no 2235 0.334804425126537 3171 793680
SGTC_157 1348-1695 65.819 µM -0.428173743542782 0.339668333507546 no 2236 0.33426231541393 3234 5380510
SGTC_1572 epiandrosterone 68.9 µM -0.428369540903033 0.339597820925417 no 2237 0.334191048412028 3144 441302 A steroid.
SGTC_2557 derrustone 83.84 µM -0.429646038862348 0.339138252905837 no 2238 0.333726570870396 3265 629853 An antioxidant.
SGTC_386 1509-0011 3.07 µM -0.430619399246914 0.338787981956697 no 2239 0.333372566678283 3167 3107280
SGTC_1482 3346-2049 8.48 µM -0.430787799757299 0.338727395917764 no 2240 0.333311335665676 3249 3826804
SGTC_33 0986-0033 35.816 µM -0.431925666216428 0.33831813114984 no 2241 0.332897719929981 3237 2848082
SGTC_3064 1327-0027 10 µM -0.432330882748506 0.338172430030948 no 2242 0.332750472317291 3167 16000455 YPR107C YTH1
SGTC_2109 5483026 200 µM -0.432628526320545 0.33806542366958 no 2243 0.332642331004887 3200 759335
SGTC_1712 st032288 53.4 µM -0.432659700844822 0.338054216818512 no 2244 0.332631005330321 3254 2883011
SGTC_867 0518-0118 155 µM -0.433734037998153 0.337668093820163 no 2245 0.332240793083883 3272 6848158
SGTC_2284 7945075 39.21 µM -0.434358329800932 0.337443798168107 no 2246 0.332014126237934 3278 1245402
SGTC_108 0509-0257 621.132 µM -0.434735440010686 0.337308337926574 no 2247 0.33187723544957 3192 536624
SGTC_2750 bromebric acid 70.15 µM -0.434893329849952 0.337251629213778 no 2248 0.331819928192777 3296 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1511 0906-3109 28.5 µM -0.435771687048392 0.336936220417533 no 2249 0.331501193973492 3205 2882180
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.436667504886515 0.33661465974991 no 2250 0.331176249356547 3241 6708739 YPR165W RHO1
SGTC_1413 3910-0535 34.4 µM -0.436822389338745 0.336559074894119 no 2251 0.331120080201649 3290 2876951
SGTC_2451 5856223 45.7 µM -0.43784953848344 0.336190542535522 no 2252 0.330747678735799 3177 2179896
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.438044409494303 0.336120642228053 no 2253 0.33067704551761 3212 165521
SGTC_17 0960-0276 49.807 µM -0.438348182599058 0.336011689998767 no 2254 0.330566951520118 3182 6821114
SGTC_346 4513-0042 7.16 µM -0.438682988799177 0.335891623300946 no 2255 0.330445627434225 3134 2827372
SGTC_1669 st015249 58.4 µM -0.440706173586481 0.33516643457994 no 2256 0.329712863318789 3287 722793
SGTC_1755 st041960 45.185 µM -0.441966141625382 0.334715122687955 no 2257 0.329256853544012 3285 2257073
SGTC_3039 9090270 49.47 µM -0.442734879269493 0.334439883330105 no 2258 0.328978755366953 3320 17173750
SGTC_2867 9039098 71.43 µM -0.442919171345101 0.334373912483359 no 2259 0.328912100008186 3155 6463460
SGTC_3018 9082602 49.47 µM -0.443264603376841 0.334250272310073 no 2260 0.328787177682207 3292 17332089
SGTC_133 0724-0033 378.92 µM -0.443873876421015 0.334032239597158 no 2261 0.328566886299976 3090 280309
SGTC_43 0570-0105 72.5 µM -0.443965199996864 0.333999563627576 no 2262 0.328533872086948 3180 1114046 YDL195W SEC31
SGTC_2845 9003024 42.97 µM -0.444118580424791 0.333944686280263 no 2263 0.328478426830804 3379 2990173
SGTC_1612 st002233 45.4 µM -0.444708313640273 0.333733721159854 no 2264 0.328265280259615 3273 1035021
SGTC_339 3091-4833 71.4 µM -0.44479251153639 0.33370360535248 no 2265 0.328234853272885 3216 3240077
SGTC_1363 1636-0063 10.4 µM -0.445648568348731 0.333397472778691 no 2266 0.327925560745011 3204 6072185
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.446533404818973 0.333081164958988 no 2267 0.32760599414429 3159 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1556 plumbagin 1.48 µM -0.447609910340364 0.332696500126883 no 2268 0.327217374790158 3261 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_687 k029-0044 34.9 µM -0.448588012036076 0.332347150307231 no 2269 0.32686444161151 3298 5829338
SGTC_2708 st078559 56 µM -0.449591922977202 0.331988733580854 no 2270 0.326502356562563 3286 17250902
SGTC_2688 kanamycin b 96.69 µM -0.44988751517428 0.33188323039574 no 2271 0.326395775126771 3380 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_601 0986-0029 62.9 µM -0.451636276009682 0.331259333144659 no 2272 0.325765516064984 3230 24747981
SGTC_734 2023-0417 80 µM -0.452516353907666 0.330945528801339 no 2273 0.325448521265657 3265 3935732
SGTC_2398 5228213 48.84 µM -0.45265600109153 0.330895746512968 no 2274 0.325398233417095 3381 80771 YMR134W ERG29
SGTC_1860 st056228 74.6 µM -0.454171197100537 0.330355792493722 no 2275 0.324852806112092 3294 688679
SGTC_1471 k673-0312 37 µM -0.454344925185278 0.330293905432389 no 2276 0.324790292919356 3256 24099884
SGTC_833 3852-0053 558 µM -0.455211643328186 0.329985224273159 no 2277 0.324478492398441 3356 3123681
SGTC_2989 9073649 71.4286 µM -0.455610909175813 0.329843064894834 no 2278 0.324334898491339 3327 21367202
SGTC_1184 1269-1718 139 µM -0.455674639627016 0.329820375818038 no 2279 0.324311980579368 3335 5403821
SGTC_1349 flufenamic acid 69 µM -0.456365330722127 0.329574518739725 no 2280 0.324063645981678 3192 3371 A non-steroidal anti-inflammatory.
SGTC_3214 9129694 49.47 µM -0.457604055230701 0.329133769258241 no 2281 0.323618464769127 3323 17158655
SGTC_340 k038-0059 454 µM -0.458224239824105 0.328913191064063 no 2282 0.323395673362837 3286 23733424
SGTC_3002 9075603 71.4286 µM -0.458462575147668 0.328828439279819 no 2283 0.323310072040581 3285 20105405
SGTC_85 0868-0259 160.055 µM -0.459271868289779 0.32854072121445 no 2284 0.323019473396766 3233 83173
SGTC_592 k241-0073 46.5 µM -0.459818053789131 0.328346600010216 no 2285 0.322823411711232 3330 4230158
SGTC_1418 3966-3099 2.4 µM -0.459989518938488 0.328285668690665 no 2286 0.322761871810632 3301 740335
SGTC_710 3448-4187 58 µM -0.460069332432494 0.328257307974723 no 2287 0.322733227910279 3286 3946412
SGTC_657 3534-0529 86.7 µM -0.460152888598224 0.328227618408234 no 2288 0.322703241946482 3319 1049549
SGTC_1975 st070967 30.8 µM -0.460619671368864 0.328061778942701 no 2289 0.32253574792023 3359 261391
SGTC_1966 st070145 16.1 µM -0.460896655171889 0.327963387632415 no 2290 0.322436375813944 3147 3748532
SGTC_1075 aripiprazole 15.2 µM -0.461446233988375 0.327768199365015 no 2291 0.322239243705959 3216 60795 An atypical antipschotic. YIL048W NEO1
SGTC_350 k064-0020 19.8 µM -0.461936163556666 0.327594235771019 no 2292 0.322063549728007 3359 2790705
SGTC_1164 k060-0068 93.7 µM -0.462112193926375 0.327531740257986 no 2293 0.322000433063578 3206 5963676
SGTC_1581 himbacine 57.9 µM -0.462457173892114 0.327409277112888 no 2294 0.321876753476843 3208 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_939 1165-0479 45.3 µM -0.463486289460084 0.327044065606456 no 2295 0.321507920073572 3327 1377347
SGTC_1732 st034308 51.822 µM -0.464066835436211 0.326838115050166 no 2296 0.321299930884082 3103 830119
SGTC_2370 9071495 200 µM -0.464969021113196 0.326518166454948 no 2297 0.320976820717995 3279 21791103
SGTC_1807 st050092 58.9 µM -0.464989207447572 0.326511009088338 no 2298 0.320969592702345 3225 5008496
SGTC_1498 4478-3555 97.6 µM -0.465691671596586 0.326261979720949 no 2299 0.32071810729765 3291 3437919
SGTC_2508 celastrol 40.54 µM -0.465926828215954 0.326178632044232 no 2300 0.320633938515525 3255 122724 Celastrol is a natural product and antioxidant.
SGTC_2805 7950783 58.44 µM -0.467041299898255 0.325783742682142 no 2301 0.32023516505826 3294 1178958 YDL195W SEC31
SGTC_1025 k007-0731 70 µM -0.469440679960471 0.324934236903064 no 2302 0.319377338319649 3184 6256118
SGTC_2405 ticlatone 3.52 µM -0.470049865157027 0.324718698138086 no 2303 0.319159695894365 3017 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_442 cape 100 µM -0.470151803975194 0.324682636400282 no 2304 0.319123282492843 3324 5281787
SGTC_1903 st060211 78.3 µM -0.470877610395248 0.324425923628028 no 2305 0.318864068811747 3357 688960
SGTC_2982 9019404 25.97 µM -0.472411092965852 0.323883815729941 no 2306 0.318316693983634 3197 22333232
SGTC_2406 ethylparaben 405.7 µM -0.474400562420236 0.323181066455888 no 2307 0.317607146034197 3089 8434 A possible steroid mimic.
SGTC_1641 st009299 47.1 µM -0.47623370337062 0.322534095852772 no 2308 0.31695394541379 3320 4046054
SGTC_1388 3346-4487 254 µM -0.476980120286504 0.322270816592584 no 2309 0.316688138890726 3323 3345614
SGTC_2338 7999974 200 µM -0.477928964460916 0.321936265036264 no 2310 0.316350382599625 3254 315925
SGTC_773 4358-1457 44.6 µM -0.479135467410187 0.321511074327896 no 2311 0.315921129719796 3360 1186886
SGTC_81 0411-0046 9.971 µM -0.479474219269413 0.321391734821513 no 2312 0.315800652250656 3278 12925265
SGTC_922 1866-0035 480 µM -0.48336748635178 0.320021494777771 no 2313 0.314417414932065 3229 3156169
SGTC_3246 9135460 32.98 µM -0.483543526351652 0.319959595082843 no 2314 0.314354931083917 3301 41446951
SGTC_1133 3473-0247 50 µM -0.483698891064766 0.319904969455855 no 2315 0.31429979016503 3241 711311
SGTC_1422 4031-0024 15.5 µM -0.484950972184939 0.319464885247846 no 2316 0.313855561945142 3294 782427
SGTC_2729 fluphenazine 10.66 µM -0.485055169564389 0.319428273172657 no 2317 0.313818605707106 3232 3372 An atypical antipsychotic.
SGTC_455 paf C-16 10 µM -0.48530783433061 0.319339501077178 no 2318 0.313728999508789 3253 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_3303 9125618 40.5795 µM -0.485361016015643 0.319320817362678 no 2319 0.313710140310168 3293 22695467
SGTC_3305 9127027 53.8275 µM -0.486246645902919 0.319009746588143 no 2320 0.31339615133021 3240 41905295
SGTC_933 2914-0560 114 µM -0.4869175116028 0.318774194909558 no 2321 0.313158394278653 3381 463887
SGTC_2926 9010726 65.15 µM -0.489226958053394 0.317963871487437 no 2322 0.312340513002149 3350 2994293
SGTC_857 0438-0306 1.35 µM -0.491179425348027 0.317279481605041 no 2323 0.311649774793973 3374 4686136
SGTC_1684 st024538 14.6195 µM -0.491502300279476 0.317166365754326 no 2324 0.31153561278386 3271 6732859
SGTC_996 3970-0799 1.8 µM -0.491791895524851 0.317064923622318 no 2325 0.311433233204523 3329 6615648 YGL040C HEM2
SGTC_2368 9071271 200 µM -0.492018505613326 0.316985554106908 no 2326 0.311353130712045 3286 27209959
SGTC_400 oxethazaine 37.5 µM -0.492519865343056 0.316809984266339 no 2327 0.31117594102265 3325 4621 A local anesthetic.
SGTC_2980 9014342 25.29 µM -0.492850547080453 0.316694206274779 no 2328 0.311059095995618 3402 2996599
SGTC_1443 4112-3303 14 µM -0.493748205963182 0.316380009302639 no 2329 0.310742007964264 3299 704433
SGTC_2928 9011484 9.79 µM -0.494248542382179 0.316204939927168 no 2330 0.310565330652341 3350 2994751
SGTC_537 1334-0398 209 µM -0.494466188589483 0.316128797651101 no 2331 0.310488489702041 3389 5846986
SGTC_3339 9145883 14.936 µM -0.495460387340642 0.315781082128143 no 2332 0.310137588662524 3340 2030670
SGTC_2008 4012253 172 µM -0.496132660658322 0.315546050584871 no 2333 0.30990040866489 3257 603940
SGTC_548 1436-0017 110 µM -0.496687196692832 0.315352236971571 no 2334 0.309704826252224 3423 9677137
SGTC_1313 1220-0047 237 µM -0.497495820127281 0.315069709367466 no 2335 0.309419724882373 3323 3528706
SGTC_2424 5537928 59.2 µM -0.501303071194757 0.313740936980973 no 2336 0.308078922088573 3285 5382802
SGTC_890 0929-0006 47.2 µM -0.501884443616934 0.313538243528718 no 2337 0.307874404319704 3284 1378169
SGTC_2671 danthron 100 µM -0.50409003541686 0.3127697839506 no 2338 0.307099054447346 3335 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1197 1601-0112 267 µM -0.506023681420427 0.312096742775761 no 2339 0.306420012600074 3276 7350313
SGTC_998 3996-0085 177 µM -0.506438868996692 0.311952310733748 no 2340 0.306274296993986 3291 715391
SGTC_2884 9058502 51.95 µM -0.50653582264358 0.311918587458623 no 2341 0.306240274232779 3393 6471554
SGTC_2164 5685496 200 µM -0.507580166463304 0.311555434556496 no 2342 0.305873901367806 3399 759046
SGTC_1854 st056233 32.9 µM -0.507918835592598 0.311437707422027 no 2343 0.305755132383695 3364 5393174
SGTC_2760 etidronate 98.04 µM -0.508088781249771 0.311378638692054 no 2344 0.305695541282538 3283 3305 A chelator and antioxidant.
SGTC_1026 k007-1105 30.6 µM -0.508170128622605 0.311350366160318 no 2345 0.305667018811512 3377 7066794
SGTC_2312 7706453 155.7 µM -0.509491254713551 0.310891360556437 no 2346 0.305203963353051 3299 976098
SGTC_2985 9022375 71.43 µM -0.510152540919598 0.31066171689803 no 2347 0.304972299130851 3454 4939335
SGTC_731 3966-0296 387 µM -0.510633806087465 0.310494635180362 no 2348 0.304803749666005 3331 660956
SGTC_523 1934-0222 13.7 µM -0.510752967805146 0.310453271622989 no 2349 0.304762023052396 3287 1361595
SGTC_794 k038-0031 316 µM -0.511100778786259 0.31033255277037 no 2350 0.304640245321812 3427 6624242
SGTC_1252 0493-0875 34.8 µM -0.51232162416783 0.309908981373904 no 2351 0.304212966799542 3289 3960963
SGTC_2305 7443522 69.23 µM -0.512959737486283 0.309687688755057 no 2352 0.30398974249784 3348 5415886
SGTC_3086 9117350 49.47 µM -0.512963681318896 0.309686321279654 no 2353 0.303988363096485 3330 2679265
SGTC_2639 lactacystin 53 µM -0.514609569483755 0.309115859947912 no 2354 0.303412938342404 3429 3870 A proteasome inhibitor.
SGTC_2266 7929956 200 µM -0.518451021712368 0.30778621206055 no 2355 0.302071812123979 3401 2967153
SGTC_464 bw-b 70c 158 µM -0.520117384703174 0.307210213894925 no 2356 0.30149088110537 3414 5353454
SGTC_3045 9092950 49.47 µM -0.520683985533868 0.307014469798315 no 2357 0.301293466112862 3452 44120432
SGTC_2751 anetholtrithion 17.25 µM -0.520840465436027 0.306960420235049 no 2358 0.301238955664338 3389 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_42 0133-0086 60.653 µM -0.52108801224478 0.306874923912807 no 2359 0.301152730739575 3302 162923 Model of phenazepam hydroxylation.
SGTC_1382 3002-2117 298 µM -0.522143203751972 0.306510605662106 no 2360 0.30078531369482 3460 1497314
SGTC_1484 3473-2379 286 µM -0.524969987262811 0.305535565435699 no 2361 0.299802027476044 3475 671917
SGTC_2692 st077426 47.7 µM -0.525539802175184 0.305339186234396 no 2362 0.299603995859443 3430 25238571
SGTC_2403 6032726 181.2 µM -0.526134063843476 0.305134441444942 no 2363 0.299397531261853 3345 2881040
SGTC_1176 0848-0131 83.3 µM -0.527761610151516 0.304574004761375 no 2364 0.298832402725765 3388 6769040
SGTC_2295 7971645 200 µM -0.528420235279584 0.304347341013498 no 2365 0.298603847935162 3326 2978226 YKL099C UTP11
SGTC_911 3456-4043 236 µM -0.53067966049589 0.303570338406753 no 2366 0.297820391489394 3387 914281
SGTC_3087 9117406 49.47 µM -0.532041492034801 0.303102441081136 no 2367 0.297348629229117 3414 42546093
SGTC_1048 3161-0300 24.5 µM -0.532611906867857 0.30290655417334 no 2368 0.297151129053602 3421 2165101
SGTC_1153 4055-0057 267 µM -0.532859989750176 0.302821377391049 no 2369 0.297065251665184 3332 882706
SGTC_1035 k081-0041 55.2 µM -0.533119215314756 0.302732386340276 no 2370 0.296975529208139 3460 731709
SGTC_181 1447-1644 8.07 µM -0.533156753594861 0.302719500576962 no 2371 0.296962537586939 3391 534600
SGTC_2463 5473429 200 µM -0.533430305261941 0.302625605931366 no 2372 0.296867871958235 3351 5399405
SGTC_1610 st001799 48.1 µM -0.534884364167508 0.302126729859628 no 2373 0.296364910499303 3288 621897
SGTC_1960 st011366 51.8 µM -0.53626524858442 0.301653301475197 no 2374 0.295887622214867 3419 3972846
SGTC_608 k048-0125 159 µM -0.536388251382564 0.301611146851383 no 2375 0.295845124709404 3445 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_697 0508-1955 564 µM -0.536584263987029 0.301543976314312 no 2376 0.295777408087078 3452 6243113
SGTC_1933 st074711 15.9 µM -0.539761073765698 0.300456271810456 no 2377 0.294680907596478 3405 17250958
SGTC_1983 st071813 46.9 µM -0.540684569631906 0.300140409851248 no 2378 0.29436250792681 3392 11838595
SGTC_1636 st007707 68.9 µM -0.542217791141864 0.299616336211168 no 2379 0.293834240275804 3498 403051
SGTC_2742 clothiapine 36.27 µM -0.542350949492495 0.299570840652763 no 2380 0.293788381603617 3394 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_717 1532-0246 73.2 µM -0.542995996935586 0.299350494797123 no 2381 0.293566279306276 3390 9561992
SGTC_648 0375-0473 33.3 µM -0.543967985136825 0.299018606080574 no 2382 0.293231751913638 3387 1713139
SGTC_702 1488-0190 94 µM -0.545063327676128 0.298644797975907 no 2383 0.292854981810212 3437 949357
SGTC_3107 9121808 49.47 µM -0.545196090483712 0.298599504387039 no 2384 0.29280933003924 3417 662681
SGTC_67 0335-0847 266 µM -0.545234389934783 0.298586438660763 no 2385 0.292796161017924 3544 4552207 YOR254C SEC63
SGTC_212 3807-4682 38.772 µM -0.5476537517586 0.297761609252589 no 2386 0.291964836852412 3441 3125501 YBL034C STU1
SGTC_540 1187-0821 17.3 µM -0.547735881800685 0.297733627029748 no 2387 0.291936635201179 3351 847520
SGTC_1377 2944-0135 198 µM -0.547760861364158 0.297725116573008 no 2388 0.291928058019731 3416 1894137
SGTC_1061 3448-9325 110 µM -0.548649822248011 0.297422322748075 no 2389 0.291622893777816 3443 723482
SGTC_824 1304-0008 100 µM -0.549837773703648 0.297017907821106 no 2390 0.291215323781612 3379 768245
SGTC_2938 9059746 27.26 µM -0.550201843817669 0.296894017615839 no 2391 0.29109046953399 3402 6471769
SGTC_219 mitoxanthrone 164.414 µM -0.550796443774801 0.296691730775976 no 2392 0.290886611132736 3405 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_27 0485-0001 32.618 µM -0.550834790311185 0.296678687197245 no 2393 0.29087346632604 3400 2054479
SGTC_1524 corynanthine 62.1 µM -0.551262676829395 0.296533159366285 no 2394 0.290726809971744 3467 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1686 st019653 115.5 µM -0.551876232482739 0.296324540984199 no 2395 0.290516576643927 3456 97252
SGTC_1322 1348-1070 12 µM -0.553634170129377 0.295727188044429 no 2396 0.289914617948714 3455 6758089
SGTC_1419 3993-2473 62.6 µM -0.553861973592405 0.295649820200631 no 2397 0.289836655580248 3427 704026
SGTC_3041 9091929 49.47 µM -0.557505922054543 0.294413509425886 no 2398 0.288590907028627 3532 25236887
SGTC_2483 5729050 27.16 µM -0.557526005087257 0.294406702316769 no 2399 0.288584048281731 3507 2865180
SGTC_3095 9117207 49.47 µM -0.559685380323906 0.293675210139472 no 2400 0.287847028015772 3423 17015229
SGTC_1718 roemerine 11.9335 µM -0.560027571428507 0.293559369559187 no 2401 0.287730315802041 3446 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2010 4012422 159 µM -0.561222347968557 0.293155072658583 no 2402 0.287322984972442 3389 952393
SGTC_2831 7999036 19.48 µM -0.5618562096299 0.29294068696383 no 2403 0.287106995643078 3492 2988270
SGTC_2347 9049783 174.81 µM -0.562588811540306 0.292692995863681 no 2404 0.286857456239263 3478 6467988 YPL169C MEX67
SGTC_2435 5706476 10.6 µM -0.563615587199796 0.29234600906206 no 2405 0.286507888228628 3484 5725375
SGTC_2815 7968870 71.43 µM -0.565331293318663 0.291766633549547 no 2406 0.285924223772182 3446 2977326 YHR190W ERG9
SGTC_2636 apigenin dimethyl ether 100 µM -0.566236213976336 0.29146126724154 no 2407 0.285616607516077 3492 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_549 1661-1316 519 µM -0.569726637854365 0.290284819283543 no 2408 0.284431560017823 3516 2857282
SGTC_2267 7931562 200 µM -0.569925764370158 0.290217770771434 no 2409 0.284364024685928 3330 934880
SGTC_1971 st069429 63.5 µM -0.571082862102151 0.289828304415145 no 2410 0.283971737559417 3470 1246522 YGL099W LSG1
SGTC_2119 5528445 120.635 µM -0.57241823418122 0.289379137869172 no 2411 0.283519332777159 3491 791935
SGTC_1751 st044839 27.194 µM -0.572589796556967 0.289321454762854 no 2412 0.283461234968315 3495 5291326
SGTC_265 mycophenolic acid 32.932 µM -0.574593385061382 0.288648203874129 no 2413 0.282783163425981 3578 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_405 ebelactone b 50 µM -0.575416439110971 0.288371853150034 no 2414 0.282504844409846 3427 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3084 9116877 49.47 µM -0.57607589019507 0.288150524222513 no 2415 0.282281943476016 3429 27241325
SGTC_1410 3909-8106 77.9 µM -0.576866443627838 0.287885299619138 no 2416 0.28201484025099 3488 1039210
SGTC_1090 efavirenz 20.7 µM -0.57754924168128 0.287656318943049 no 2417 0.281784242202028 3481 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_964 1287-0107 19.4 µM -0.57763967845174 0.287625996852571 no 2418 0.281753706250624 3512 51516812 YPR165W RHO1
SGTC_1456 k015-0012 13 µM -0.577764556904424 0.287584129466944 no 2419 0.281711543696517 3561 2989616
SGTC_495 decylubiquinone 155 µM -0.57808698319835 0.287476044510339 no 2420 0.28160269738184 3450 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1668 st014914 51.6 µM -0.579448807025909 0.287019740845462 no 2421 0.281143189815923 3499 2839556
SGTC_2149 5554786 194.827 µM -0.579831920249232 0.286891433696394 no 2422 0.281013984781734 3443 745063 YPR165W RHO1
SGTC_496 calpeptin 138 µM -0.581309505859423 0.286396835228795 no 2423 0.280515937547562 3452 73364 A calpain inhibitor.
SGTC_12 0849-0099 9.267 µM -0.581510309284511 0.286329650700239 no 2424 0.280448286071718 3450 6071388
SGTC_2384 9036245 200 µM -0.582820346103417 0.285891524153486 no 2425 0.280007123387015 3425 6462766
SGTC_1579 chlormadinone acetate 49.4 µM -0.586082412302025 0.284801951265206 no 2426 0.278910067346312 3518 45114258 A steroidal progestin.
SGTC_379 3970-0972 5.9 µM -0.587814007210451 0.284224382069078 no 2427 0.278328570551734 3465 2898042 YBL034C STU1
SGTC_1017 4239-0030 168 µM -0.588062709671613 0.284141473991749 no 2428 0.278245100913204 3418 1149593
SGTC_1401 3807-4679 7.6 µM -0.588734229991193 0.283917672083036 no 2429 0.278019785929599 3495 3291456
SGTC_686 1319-0111 510 µM -0.589371578569264 0.283705336875317 no 2430 0.27780601895501 3557 4562600
SGTC_488 nitrendipine 139 µM -0.59001474355796 0.283491141035492 no 2431 0.277590382539725 3513 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2686 alizarin 95.37 µM -0.590670578600126 0.283272805478989 no 2432 0.277370582433866 3428 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_313 3474-0040 5.03 µM -0.591005561883504 0.283161316547313 no 2433 0.277258347165182 3470 1043375 YIL048W NEO1
SGTC_3266 9136860 49.47 µM -0.591402336450517 0.283029289520807 no 2434 0.277125437633228 3452 4871271 YPR165W RHO1
SGTC_2226 7298446 200 µM -0.591585168283689 0.282968462041533 no 2435 0.27706420404769 3505 3283010
SGTC_2565 isoliquiritigenin 100 µM -0.591700458171055 0.282930108746431 no 2436 0.277025594848329 3459 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2374 9071832 200 µM -0.592191130961661 0.282766905368773 no 2437 0.276861303882152 3492 17381698
SGTC_325 2810-4341 181 µM -0.594465668646147 0.282010959474503 no 2438 0.276100348955324 3525 774970
SGTC_289 k017-0060 526 µM -0.595224060849455 0.281759123272851 no 2439 0.275846854508901 3458 5512909
SGTC_736 0958-0254 92.6 µM -0.595937482506209 0.281522319251011 no 2440 0.275608496006036 3550 6812352
SGTC_2290 7904846 200 µM -0.59605362203143 0.281483778477302 no 2441 0.27556970267353 3488 2962154
SGTC_1946 st076057 65.1 µM -0.596313054890087 0.281397695163831 no 2442 0.275483055697742 3436 953009
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.596655765245514 0.281283998736544 no 2443 0.275368615741763 3428 279621
SGTC_2238 6671620 73.2395 µM -0.597004141561351 0.28116844532484 no 2444 0.27525230775514 3507 729941
SGTC_257 daunorubicin 18.5 µM -0.597315365642182 0.281065234381013 no 2445 0.275148423770059 3512 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3282 9108498 15.4605 µM -0.599297566283879 0.280408308961742 no 2446 0.274487235259079 3464 16459645
SGTC_1935 st074532 41.6 µM -0.600322307061332 0.280068989133953 no 2447 0.274145727493538 3572 2829742
SGTC_3083 9117465 49.47 µM -0.60035580609445 0.280057900043836 no 2448 0.274134567062813 3514 16420915
SGTC_22 0964-0034 14.468 µM -0.600406303254548 0.280041184514068 no 2449 0.274117744014655 3504 138402
SGTC_2703 st077852 53.4 µM -0.602012692558057 0.279509691351569 no 2450 0.273582844322106 3525 6281836
SGTC_1539 benzyladenosine 56 µM -0.605104861392752 0.278487991200114 no 2451 0.272554662164091 3482 92208 A nucleotide analog.
SGTC_2455 5377712 9.75 µM -0.60649427126 0.278029501996294 no 2452 0.2720932926649 3492 2243908
SGTC_3100 9120536 49.47 µM -0.607062241541745 0.277842184470013 no 2453 0.271904803480404 3458 16421196
SGTC_2041 5107442 45.335 µM -0.608687786336071 0.277306417895092 no 2454 0.271365702081298 3569 793005
SGTC_584 0986-0246 15.4 µM -0.608761809819785 0.277282032379091 no 2455 0.271341165357713 3598 53315 YDR232W HEM1
SGTC_2480 5767542 37.17 µM -0.609137274673364 0.27715835935008 no 2456 0.271216726242926 3528 2867358
SGTC_2092 5303694 80.6725 µM -0.609275326029883 0.277112893892976 no 2457 0.271170979478206 3497 1963699
SGTC_1234 0326-0494 15.5 µM -0.609338574181351 0.277092065138477 no 2458 0.27115002190882 3585 1547813
SGTC_300 r073-0011 5.04 µM -0.611866346106644 0.276260252121009 no 2459 0.270313094658587 3587 2735780
SGTC_1357 1503-1303 39.5 µM -0.613989864398068 0.275562415020057 no 2460 0.269611012465098 3535 292895
SGTC_826 1683-5028 118 µM -0.614406575437738 0.275425575974671 no 2461 0.269473345872429 3540 722377
SGTC_3056 9094900 49.47 µM -0.615122144513672 0.275190676326018 no 2462 0.269237029378892 3472 25236784
SGTC_2330 7979373 200 µM -0.615484027260933 0.275071918750559 no 2463 0.269117557290229 3500 1863007
SGTC_2797 7859098 81.82 µM -0.617858269203276 0.274293400173802 no 2464 0.268334384654102 3524 972681
SGTC_2551 apiole 73.87 µM -0.618101486782272 0.274213710128625 no 2465 0.268254221151621 3447 10659 A possible DNA adduct former.
SGTC_2813 7971799 71.43 µM -0.618264003963338 0.274160467877882 no 2466 0.268200662880629 3547 2234054
SGTC_2127 5253358 187.912 µM -0.618470338327432 0.274092878038609 no 2467 0.268132672212243 3495 20612
SGTC_2093 5331342 194.4 µM -0.618568383560405 0.274060763823656 no 2468 0.268100367687681 3563 33839
SGTC_991 3996-0057 64.7 µM -0.619592681917879 0.273725371346348 no 2469 0.267762992976687 3528 715343
SGTC_3342 9147791 14.508 µM -0.620174334660345 0.273535007536729 no 2470 0.267571508396642 3522 1838168
SGTC_2145 5634607 200 µM -0.620920884713557 0.27329077205402 no 2471 0.267325839556725 3505 308662
SGTC_2781 5567276 71.43 µM -0.622200860051343 0.272872276839944 no 2472 0.266904900293568 3563 2853274
SGTC_3049 9092223 49.47 µM -0.625737635779599 0.271717562945322 no 2473 0.265743521588491 3521 8623917
SGTC_1865 st057639 52.2 µM -0.626337044195476 0.271522104759341 no 2474 0.265546946737972 3568 688818
SGTC_1735 st034310 56.75 µM -0.626513189575809 0.271464679681749 no 2475 0.26548919422107 3573 871153
SGTC_1289 0976-0073 69.1 µM -0.626753467257037 0.271386356617458 no 2476 0.265410425020808 3583 3391136
SGTC_1034 k072-0165 12.7 µM -0.626848388788102 0.271355418248325 no 2477 0.265379310571279 3575 5835461
SGTC_1979 st071809 45.3 µM -0.626908817499354 0.271335723255638 no 2478 0.265359503531498 3603 4976333
SGTC_121 0557-0495 61.343 µM -0.62749690397343 0.271144090667541 no 2479 0.265166782493249 3644 3104427
SGTC_3213 9129884 49.47 µM -0.629221814148194 0.27058240472283 no 2480 0.264601924756983 3489 17190742
SGTC_721 1187-1332 279 µM -0.629657252214807 0.270440704091357 no 2481 0.26445942832323 3491 25730
SGTC_2941 9056145 11.23 µM -0.629885434114987 0.270366463751419 no 2482 0.264384771747183 3494 2119517
SGTC_2292 7671323 168.05 µM -0.629902944797146 0.270360766967609 no 2483 0.264379043043764 3564 937504
SGTC_926 2268-1401 59.4 µM -0.630935790057915 0.270024855617368 no 2484 0.26404125459357 3562 2931578
SGTC_2834 9001755 58.44 µM -0.634282002634027 0.268938006144012 no 2485 0.26294839984159 3470 2989575
SGTC_2083 5306046 65.942 µM -0.635269821487601 0.268617583076665 no 2486 0.262626226236144 3589 539837
SGTC_161 4065-0411 162.148 µM -0.635278438623578 0.268614788743392 no 2487 0.262623416676859 3542 1906281 YLR208W SEC13
SGTC_2172 5754775 163.918 µM -0.636212540551009 0.268311968241096 no 2488 0.262318950244153 3483 2263357
SGTC_1019 4262-0212 3.4 µM -0.636863658818353 0.268100988007821 no 2489 0.262106828075465 3606 4677213
SGTC_1877 wortmannin 25 µM -0.638545113300223 0.267556537029201 no 2490 0.26155944853736 3590 312145 A covalent inhibitor of PI 3-kinase.
SGTC_3308 9128332 17.569 µM -0.639173301105371 0.267353274433523 no 2491 0.261355099379631 3602 17332805 YDL196W YDL196W
SGTC_2281 7943571 200 µM -0.639245215883092 0.267330009954622 no 2492 0.261331710773091 3635 1244024
SGTC_1832 st054113 55 µM -0.63998332903066 0.267091288909856 no 2493 0.261091718824809 3586 1251267
SGTC_2860 9025725 38.96 µM -0.640024471437588 0.267077985772772 no 2494 0.261078345014247 3507 40546248
SGTC_1417 3966-0327 90.4 µM -0.640200438712998 0.267021091642801 no 2495 0.261021148810333 3613 651118
SGTC_1561 5-methoxyflavone 52.9 µM -0.640717739091486 0.266853872387571 no 2496 0.260853043396384 3560 94525
SGTC_3106 9121286 49.47 µM -0.641150938120713 0.266713879921341 no 2497 0.260712310981132 3622 15943471
SGTC_2602 kawain 100 µM -0.641677883763473 0.266543642383696 no 2498 0.260541175995415 3582 5369129
SGTC_10 0279-0212 42.575 µM -0.643095720359848 0.266085862435367 no 2499 0.260080995643952 3592 39851 YBR002C RER2
SGTC_1742 st038235 28.8875 µM -0.646066392492165 0.265128007959729 no 2500 0.259118179574516 3560 564103 YBR002C RER2
SGTC_1440 4100-1550 40 µM -0.64739991456413 0.264698601392274 no 2501 0.25868657560388 3597 742806
SGTC_621 3584-0052 32.1 µM -0.647763578834643 0.264581559507622 no 2502 0.258568937674461 3616 2273927
SGTC_1136 pergolide 1.05886 µM -0.647842319224605 0.264556221130283 no 2503 0.258543470422901 3573 47811 A dopamine receptor agonist.
SGTC_3180 9109287 49.47 µM -0.648004986117689 0.264503879412811 no 2504 0.258490862673 3587 18891271
SGTC_287 k060-0039 29.6 µM -0.648304873762822 0.264407397657874 no 2505 0.258393891189931 3620 5861974
SGTC_1562 morin hydrate 59.1 µM -0.648849473015051 0.264232231547596 no 2506 0.258217838118485 3619 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1283 0922-0125 16.4 µM -0.651128873095547 0.263499722122011 no 2507 0.257481649807026 3585 3360884
SGTC_1467 k284-1082 293 µM -0.652692324757159 0.262997890243555 no 2508 0.256977325789525 3583 3334705
SGTC_2277 7947813 106.88 µM -0.653060308253476 0.262879847099947 no 2509 0.256858699774743 3659 1246798
SGTC_1115 galangin 695.678 nM -0.653121358566166 0.262860265769171 no 2510 0.256839021878833 3642 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1901 st060216 58.6 µM -0.653779777632969 0.262649131268669 no 2511 0.256626848398773 3606 688792
SGTC_2430 5571206 200 µM -0.655234765075604 0.262182870025737 no 2512 0.256158307178496 3644 1731771
SGTC_178 4092-0806 87.505 µM -0.656009800440826 0.261934677578239 no 2513 0.255908909225735 3600 2169044
SGTC_546 peri-Naphthalide 147 µM -0.656081799483573 0.261911627175018 no 2514 0.255885747150693 3549 223824 A penicillin ester.
SGTC_1091 telmisartan 47.6 µM -0.656120273881593 0.2618993100712 no 2515 0.255873370394473 3673 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_440 fluspirilene 35.1 µM -0.65614611909286 0.261891036212491 no 2516 0.255865056472847 3676 3396 An atypical antipsychotic.
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.657107455201837 0.261583377771418 no 2517 0.255555912786521 3713 5282309
SGTC_2620 irigenin 100 µM -0.659071693678171 0.260955335627018 no 2518 0.254924865791385 3629 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_556 4058-0063 51.5 µM -0.660467593679295 0.260509484823831 no 2519 0.254476903938979 3667 6615692
SGTC_330 1488-0319 80.1 µM -0.660969064279177 0.260349410809654 no 2520 0.254316076483196 3598 6846614
SGTC_473 2-arachidonoylglycerol 10 µM -0.661717198518378 0.260110693721142 no 2521 0.25407624020629 3544 5282280 An endocannabinoid.
SGTC_273 hydroxyurea 18.1 mM -0.661854135252863 0.2600670117259 no 2522 0.254032353987018 3658 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1128 3448-9350 235 µM -0.663722688416184 0.259471332644579 no 2523 0.253433907657061 3590 619386
SGTC_1050 3232-1156 69.3 µM -0.663948669815628 0.259399339464303 no 2524 0.253361582266299 3582 700529
SGTC_935 2996-0153 430 µM -0.664054446055134 0.259365644803547 no 2525 0.253327732288383 3622 23738523
SGTC_1038 k292-0204 154 µM -0.664820956612904 0.259121543057754 no 2526 0.253082508504841 3579 4454212
SGTC_2789 5281112 71.43 µM -0.665576524758688 0.258881042312181 no 2527 0.252840907711813 3625 765948
SGTC_547 1120-0019 610 nM -0.666150023214612 0.258698572296109 no 2528 0.25265760668557 3594 3676939
SGTC_3186 9110464 49.47 µM -0.666168289561721 0.258692761586263 no 2529 0.25265176956357 3631 17018021
SGTC_1105 epirubicin 18.1 µM -0.666205140561735 0.25868103911592 no 2530 0.252639993819215 3586 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1731 st035964 63 µM -0.666433159155674 0.25860851148168 no 2531 0.252567136861255 3600 6739575
SGTC_338 4055-0136 114 µM -0.669374738216018 0.257673805672175 no 2532 0.251628230984665 3590 2900563
SGTC_1001 4048-4355 44.4 µM -0.670641125098418 0.25727194381807 no 2533 0.251224588613489 3624 21824233
SGTC_2999 9069765 71.4286 µM -0.671100282606781 0.25712632013038 no 2534 0.251078323471168 3640 2097066
SGTC_2958 9077254 16.72 µM -0.671879854586796 0.256879173880708 no 2535 0.250830093151809 3653 16457351
SGTC_2890 9046729 58.44 µM -0.672026753044902 0.256832616782328 no 2536 0.250783332483353 3560 903329
SGTC_484 loperamide 105 µM -0.672627299887087 0.256642328826829 no 2537 0.250592214626931 3585 3955 An opioid-receptor agonist.
SGTC_2057 5236571 38.335 µM -0.672850915781432 0.256571493147397 no 2538 0.250521070887137 3629 54684039 YBR257W POP4
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.673156253389717 0.256474786609765 no 2539 0.250423944544822 3660 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_778 3456-2434 196 µM -0.673286916355442 0.256433408833634 no 2540 0.250382387417508 3668 5539063
SGTC_2909 7941780 10.49 µM -0.673328991247858 0.25642008548125 no 2541 0.25036900634981 3636 1243215
SGTC_2144 5628481 200 µM -0.674370798855249 0.25609030381483 no 2542 0.25003780146573 3619 2818399
SGTC_1920 st075728 45.7 µM -0.674651728660038 0.256001414051221 no 2543 0.249948529850781 3650 3400306
SGTC_38 0929-0051 58.268 µM -0.676080920018874 0.255549449091205 no 2544 0.24949463495486 3638 1379719
SGTC_3133 9127736 49.47 µM -0.676153360445963 0.255526551762116 no 2545 0.249471640368748 3646 27243420
SGTC_503 tyrphostin 8 294 µM -0.676304467400266 0.255478792577178 no 2546 0.249423678485954 3611 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_361 000s-0510 1.45 µM -0.677801372663638 0.255005929582433 no 2547 0.248948820308313 3628 660
SGTC_545 4218-0007 221 µM -0.678839953585036 0.254678117643472 no 2548 0.248619637730953 3607 2840508
SGTC_3277 9138724 49.47 µM -0.67947173929244 0.254478812303113 no 2549 0.248419504081217 3575 15943418
SGTC_2381 9035592 200 µM -0.679529697385369 0.254460532732736 no 2550 0.248401148731545 3598 4749657
SGTC_1231 0242-0792 125 µM -0.68438517943449 0.252931594854338 no 2551 0.246865986055286 3643 3707635
SGTC_1082 camptothecin 424.86 nM -0.685768616869869 0.252496852326359 no 2552 0.246429514668136 3602 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2086 5274770 176.623 µM -0.686851085823431 0.252156963332174 no 2553 0.246088286757354 3661 689278
SGTC_645 0845-0943 5.41 µM -0.687081310349777 0.252084705294365 no 2554 0.246015745517825 3643 1885106
SGTC_39 0986-0283 58.349 µM -0.687959596559011 0.251809147624171 no 2555 0.245739112500105 3685 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1988 st071872 53.4 µM -0.688761570260982 0.251557671571147 no 2556 0.245486661512073 3665 16414116
SGTC_1724 st037281 8.293 µM -0.689039705761986 0.251470487218424 no 2557 0.245399140593937 3675 574124 YDL195W SEC31
SGTC_1356 1502-0781 85.8 µM -0.68912205314003 0.251444677673702 no 2558 0.245373231556222 3637 567702
SGTC_2325 6158266 200 µM -0.690562312932929 0.250993493895124 no 2559 0.244920318992503 3673 3623240
SGTC_1070 indatraline 8.81 µM -0.692394338449469 0.250420203045864 no 2560 0.244344860138371 3654 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_632 0781-2353 4.65 µM -0.692913510046753 0.250257866362407 no 2561 0.244181915387655 3707 6811515 YHR007C ERG11
SGTC_342 k048-0088 23.3 µM -0.693698955788486 0.250012376107896 no 2562 0.243935510500021 3652 6820570
SGTC_1924 st058459 75.1 µM -0.693780225042703 0.249986982783081 no 2563 0.243910022903443 3626 688683
SGTC_1872 amphotericin b 148 nM -0.694119756688794 0.249880907807283 no 2564 0.243803554812376 3679 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3118 9124250 49.47 µM -0.694715278914275 0.249694915103721 no 2565 0.24361687548367 3605 1504786
SGTC_3076 9116187 49.47 µM -0.695397573263972 0.249481912252587 no 2566 0.243403090469887 3625 27241210
SGTC_1649 st011737 51.3 µM -0.695809734124091 0.249353288134197 no 2567 0.243273996194815 3662 1761035
SGTC_369 0957-0393 4.5 µM -0.696175552702417 0.24923915570894 no 2568 0.24315944794764 3658 6997992
SGTC_3129 9127257 49.47 µM -0.69784638677249 0.248718222433211 no 2569 0.242636633045977 3609 837894
SGTC_562 3772-2733 112 µM -0.698180835095592 0.248614017698977 no 2570 0.24253205513622 3685 2876874 YIL048W NEO1
SGTC_3322 9139058 2.11 µM -0.700100708572385 0.248016289064632 no 2571 0.241932206683681 3736 4908926 YPR165W RHO1
SGTC_516 3992-2719 87.3 µM -0.70012688495001 0.24800814467819 no 2572 0.24192403365793 3650 5350887 YDR037W KRS1
SGTC_1676 st018489 23.4 µM -0.700232712469616 0.247975219490883 no 2573 0.241890992757976 3710 3696235
SGTC_1871 st057448 67.3 µM -0.700375909781009 0.247930671481946 no 2574 0.241846288360182 3755 691747
SGTC_1713 st033146 12.748 µM -0.700660689500184 0.24784209054752 no 2575 0.241757397041311 3660 674619
SGTC_869 0564-0080 44.1 µM -0.700965305872606 0.247747358111786 no 2576 0.241662333528365 3685 6843321
SGTC_2389 9091542 195.52 µM -0.701668620388271 0.247528708689736 no 2577 0.241442923359036 3683 3626624 YOL127W RPL25
SGTC_674 0498-0004 451 µM -0.702225964850655 0.247355512312049 no 2578 0.241269127752686 3660 4231473
SGTC_1660 st012960 28.1 µM -0.703318806538113 0.247016096770511 no 2579 0.240928546554716 3663 24207266
SGTC_2045 5106652 78.05 µM -0.703433725733922 0.246980419570748 no 2580 0.240892747495403 3652 673349
SGTC_1406 3909-7906 11.9 µM -0.705560922029003 0.246320519744614 no 2581 0.24023061662198 3687 X1406
SGTC_1405 3909-7894 12 µM -0.705604977416221 0.246306862859033 no 2582 0.240216914023841 3687 7104060
SGTC_470 aa-861 153 µM -0.706254813596348 0.246105464999037 no 2583 0.240014844210188 3672 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2976 9009005 19.48 µM -0.70660512637394 0.245996932376145 no 2584 0.239905951159014 3700 2993148
SGTC_2801 7907800 81.82 µM -0.708364004779334 0.245452391474991 no 2585 0.239359619725661 3728 6620925
SGTC_1416 3966-0321 25.3 µM -0.709515053081181 0.245096382993534 no 2586 0.239002456752719 3708 582530 YLR208W SEC13
SGTC_1398 3558-0053 112 µM -0.710030425691301 0.244937073121096 no 2587 0.238842634393372 3620 4532369
SGTC_1067 clotrimazole 1.36 µM -0.710128721772605 0.244906694566873 no 2588 0.238812158404369 3710 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2963 9082507 9 µM -0.710797338438222 0.244700111375257 no 2589 0.238604915097442 3708 16459611
SGTC_2050 5263056 171 µM -0.711190740263874 0.244578605458475 no 2590 0.238483022933925 3705 763468 YGL055W OLE1
SGTC_1307 1187-1599 12.2 µM -0.712014287377764 0.244324350308875 no 2591 0.238227964379561 3700 1538471
SGTC_2588 indole-3-carbinol 100 µM -0.712715074813776 0.244108107211037 no 2592 0.238011043137321 3694 3712 Induces cell cycle arrest.
SGTC_704 1310-0270 142 µM -0.712963706974025 0.244031411201921 no 2593 0.237934107745446 3674 5718033
SGTC_2469 5655019 90.81 µM -0.714083761314867 0.243686067253602 no 2594 0.237587693304916 3732 2788239
SGTC_1390 3413-2614 145 µM -0.714102051129938 0.243680430184618 no 2595 0.237582038862645 3742 3421432
SGTC_268 camptothecin 39.6153 µM -0.714286037427155 0.243623728035834 no 2596 0.237525162138989 3696 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2251 lansoprazole 556 µM -0.715825046995578 0.24314970478083 no 2597 0.237049692249798 3627 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1491 4138-0063 26.5 µM -0.717284753836654 0.242700568407522 no 2598 0.236599206312092 3661 23883227
SGTC_2342 7990637 118.86 µM -0.718383524625326 0.242362784741319 no 2599 0.236260421245043 3764 2033102 YER133W GLC7
SGTC_854 0422-0053 192 µM -0.719037932664813 0.242161727989156 no 2600 0.236058773977057 3726 3596728
SGTC_527 4476-4215 268 µM -0.720572322248439 0.241690665286566 no 2601 0.235586343959815 3705 4418754
SGTC_1750 st081859 2.357 µM -0.720843636193011 0.241607422786267 no 2602 0.235502862206308 3711 5291695
SGTC_1875 nocodazole 6 µM -0.721198950001251 0.241498431626297 no 2603 0.235393558863599 3686 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2661 dactinomycin 12.96 µM -0.72334324420741 0.24084124472167 no 2604 0.234734515494966 3716 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_856 0433-0016 11.3 µM -0.724267069942478 0.240558409236023 no 2605 0.234450894746614 3738 3911780
SGTC_2662 daunorubicin 22.37 µM -0.724433526067639 0.240507466804605 no 2606 0.234399811757318 3617 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2775 cyproheptadine 69.59 µM -0.724851786243142 0.240379487890647 no 2607 0.234271480914079 3709 2913 A selective serotonin reuptake inhibitor.
SGTC_1150 3909-7983 10.9 µM -0.725049327974801 0.240319057129545 no 2608 0.234210884563338 3721 23965914
SGTC_2513 baicalein 25.65 µM -0.725217844578123 0.240267512101342 no 2609 0.234159198592467 3707 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3341 9147222 25.867 µM -0.727734973931055 0.239498302465279 no 2610 0.233387918385229 3705 1939759
SGTC_1605 st000082 49.1 µM -0.72821111905598 0.239352948640402 no 2611 0.233242180197646 3734 1114022
SGTC_682 0kpi-0099 17 µM -0.728371464877028 0.239304010381856 no 2612 0.233193113025097 3729 1714895 YML126C ERG13
SGTC_3238 9133470 49.47 µM -0.731931864895615 0.238218769869338 no 2613 0.23210507793847 3721 3534688
SGTC_940 3232-1287 54.8 µM -0.733236478675615 0.23782178843025 no 2614 0.231707105014998 3677 1585493 YIL048W NEO1
SGTC_443 clozapine 122 µM -0.733503836467 0.237740478841314 no 2615 0.231625594390361 3638 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_512 prima-1 270 µM -0.733707162373558 0.237678653015528 no 2616 0.231563616166561 3742 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2027 5150920 200 µM -0.733750688530343 0.237665419052662 no 2617 0.231550349634711 3698 786715
SGTC_1119 parthenolide 318.541 nM -0.733874780720711 0.237627691512335 no 2618 0.231512529347331 3857 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2798 7813637 45.45 µM -0.733896088698983 0.237621213614071 no 2619 0.231506035539246 3715 956368
SGTC_429 1112-0049 25.5 µM -0.733978282678011 0.237596226499712 no 2620 0.231480987097448 3708 2836170
SGTC_2753 fluvastatin 17.09 µM -0.737990257855114 0.236378333443696 no 2621 0.23026018460977 3760 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2156 5649887 115 µM -0.738194720797235 0.236316357933735 no 2622 0.230198065233871 3783 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_203 k066-0004 30.888 µM -0.73881523784115 0.236128325533544 no 2623 0.230009598836151 3802 6795412
SGTC_1263 0774-1208 64.8 µM -0.739876012874438 0.235807074761019 no 2624 0.229687615255626 3755 906585
SGTC_2080 5212524 12.4 µM -0.741994278922669 0.23516628940774 no 2625 0.229045400942865 3697 260183
SGTC_918 glabranin 770.725 nM -0.742783029851403 0.234927934503889 no 2626 0.228806525659357 3771 124049 Also referred to as licorice root.
SGTC_1278 0874-0585 172 µM -0.742976392751303 0.234869521997078 no 2627 0.228747986549989 3798 766306
SGTC_2179 6298986 200 µM -0.743279639920491 0.234777930998412 no 2628 0.228656197771303 3681 738374
SGTC_1836 st055642 81 µM -0.745412067792241 0.234134422899663 no 2629 0.228011325374578 3771 8571
SGTC_907 3448-6986 75.5 µM -0.747734751454949 0.233434613524482 no 2630 0.227310082716775 3772 590582
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.7480593560538 0.233336904781196 no 2631 0.227212178043255 3755 75037 A free radical scavenger.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.748243932455753 0.233281355837646 no 2632 0.227156518168537 3808 688801
SGTC_853 0419-0306 21 µM -0.749265420884996 0.232974067888803 no 2633 0.226848622572455 3759 762713
SGTC_655 k060-0012 42 µM -0.751209174134709 0.232389962189827 no 2634 0.226263389931811 3757 5994525
SGTC_2220 6782180 200 µM -0.751322967912236 0.232355791958764 no 2635 0.226229154916733 3677 833803
SGTC_2396 5342950 42.78 µM -0.752444323501419 0.23201921849826 no 2636 0.225891950098297 3773 1886677
SGTC_1259 0671-0132 43 µM -0.753090160041356 0.23182549473324 no 2637 0.225697868508477 3719 X1259
SGTC_1867 st057372 64 µM -0.753208987385796 0.231789861350324 no 2638 0.22566216975117 3745 688837
SGTC_3004 9076122 71.4286 µM -0.753864469172656 0.231593353416642 no 2639 0.225465303774384 3766 44782551
SGTC_7 0192-1582 4.227 µM -0.755546930670105 0.231089390891419 no 2640 0.224960442217751 3799 252616
SGTC_1987 st072290 61.9 µM -0.755668978298761 0.231052856713699 no 2641 0.224923843941459 3775 54697379
SGTC_3160 9100216 49.47 µM -0.758411416154293 0.230232776060595 no 2642 0.224102362837764 3684 17191039
SGTC_1575 cyproterone acetate 48 µM -0.759201043014493 0.229996953428684 no 2643 0.223866151119591 3767 9880 An androgen receptor antagonist and liver toxin.
SGTC_1494 4358-1428 177 µM -0.760554080524656 0.229593182251282 no 2644 0.223461727928827 3778 1564571
SGTC_1948 st076329 66.6 µM -0.761163212158909 0.229411535925127 no 2645 0.223279794123672 3666 24208413
SGTC_900 1112-0045 141 µM -0.761342313186889 0.229358142363702 no 2646 0.22322631675063 3699 56211 YIL048W NEO1
SGTC_1372 2752-0194 270 µM -0.76242526986689 0.229035439988319 no 2647 0.222903114517326 3740 823334
SGTC_2262 9014885 67.46 µM -0.762699588476882 0.228953738234703 no 2648 0.22282128803162 3698 6457424
SGTC_844 0330-0132 15.3 µM -0.763893947504738 0.228598206681525 no 2649 0.22246522228117 3795 2828079
SGTC_2143 5623677 140.463 µM -0.764441314750009 0.228435372474767 no 2650 0.222302148077368 3729 5375313
SGTC_3003 9075612 71.4286 µM -0.766253336517216 0.227896786221849 no 2651 0.221762788943823 3797 6501993
SGTC_1727 st034309 9.9045 µM -0.766387943761694 0.227856805511172 no 2652 0.221722752143359 3868 870305
SGTC_1520 flindersine 88 µM -0.767938911374511 0.227396425766396 no 2653 0.221261739326582 3885 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1994 st072947 40.9 µM -0.768344618130261 0.227276084774585 no 2654 0.22114123674209 3841 5286565 YDL195W SEC31
SGTC_1980 st071811 45.7 µM -0.769375537818826 0.226970454246162 no 2655 0.220835203073711 3891 4974850
SGTC_1681 tripelennamine 100 µM -0.769397856414861 0.22696384015115 no 2656 0.220828580369645 3762 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1655 st012546 55.1 µM -0.769868915640059 0.226824267551303 no 2657 0.220688827238346 3736 720985 YLR208W SEC13
SGTC_1702 st027038 51 µM -0.770762988804776 0.22655949115647 no 2658 0.220423714349299 3806 5521182
SGTC_569 4130-2812 160 µM -0.770769563933542 0.226557544603411 no 2659 0.220421765351478 3654 743552
SGTC_2015 5119600 184 µM -0.770867306831065 0.226528609137326 no 2660 0.220392793594067 3796 2828786
SGTC_636 0kpi-0074 126 µM -0.771382837348009 0.226376027810745 no 2661 0.220240022447988 3808 616434
SGTC_234 nsc-17383 10.7 µM -0.771438829035653 0.226359459472253 no 2662 0.220223433654526 3800 408974
SGTC_3114 9122766 49.47 µM -0.771666707166521 0.22629203577948 no 2663 0.220155927038974 3790 17176985
SGTC_1754 st042065 16.137 µM -0.771686051504191 0.226286312774733 no 2664 0.220150197019099 3704 1126236 YIL048W NEO1
SGTC_1448 4255-0083 152 µM -0.773047516829162 0.225883729929772 no 2665 0.219747129917003 3851 5399660
SGTC_490 phenamil 164 µM -0.77318495007147 0.22584311368527 no 2666 0.219706465826735 3756 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1475 4092-1048 11.7 µM -0.773715196790734 0.22568644627812 no 2667 0.219549615603116 3808 2881759
SGTC_1424 4048-1941 275 µM -0.773757829124885 0.225673852742557 no 2668 0.219537007491902 3864 X1424
SGTC_2 0422-0095 29 µM -0.774487431149797 0.225458390896875 no 2669 0.219321299037289 3660 6790840
SGTC_2084 5306078 60.6385 µM -0.775898898419818 0.225041895283848 no 2670 0.218904341548336 3738 679340
SGTC_1407 3909-7909 12.3 µM -0.77795292894395 0.224436571794407 no 2671 0.218298381709916 3781 4411780
SGTC_746 1095-0025 46.6 µM -0.778629342339428 0.224237434975415 no 2672 0.218099044615327 3808 6749286
SGTC_252 miconazole 1.30953 nM -0.779693026733801 0.223924488183131 no 2673 0.217785792177349 3749 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_141 0443-0274 32.331 µM -0.779877664942362 0.223870191030038 no 2674 0.217731443126247 3852 1627241
SGTC_2380 9035439 200 µM -0.780995930281424 0.223541499074012 no 2675 0.21740244416017 3919 6462575
SGTC_2647 atorvastatin 60.16 µM -0.781411210810008 0.223419505514927 no 2676 0.217280339784282 3794 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2449 5812982 45.77 µM -0.78189806339236 0.223276535065096 no 2677 0.217137241621366 3768 776185
SGTC_1841 st054148 70 µM -0.783512658868419 0.222802761455945 no 2678 0.216663061473344 3844 675442
SGTC_2003 4023581 200 µM -0.784245787646619 0.222587827429452 no 2679 0.216447951476015 3849 16641307
SGTC_831 k061-1017 217 µM -0.785676051370874 0.222168852267746 no 2680 0.21602864850479 3863 1240153
SGTC_1501 4491-0275 38.4 µM -0.787380130730053 0.221670254838342 no 2681 0.215529687233428 3764 5104718
SGTC_839 0122-0028 230 µM -0.788688625994146 0.221287835918102 no 2682 0.21514700864137 3821 759448
SGTC_1749 st037932 54.2 µM -0.789731682008097 0.220983264352902 no 2683 0.214842242334993 3850 594497
SGTC_2462 5162487 171.77 µM -0.79098627156684 0.220617243213381 no 2684 0.214476001352323 3729 2259986
SGTC_2472 5377652 49.4 µM -0.791769617412977 0.220388881650843 no 2685 0.214247510489049 3889 1610903
SGTC_1073 triclabendazole 3.09 µM -0.792333638641596 0.220224541696899 no 2686 0.214083081226748 3897 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_550 4123-0385 25.7 µM -0.792837910073763 0.220077670674153 no 2687 0.213936133042433 3844 5731123
SGTC_3271 9137798 49.47 µM -0.792939645305022 0.220048046703815 no 2688 0.213906493812299 3725 6498326
SGTC_2995 9067767 71.4286 µM -0.794281384537597 0.219657563859191 no 2689 0.213515819363876 3840 11673567
SGTC_3164 9100705 49.47 µM -0.795319218281831 0.219355798938676 no 2690 0.213213918538009 3828 17174235
SGTC_2948 9070189 9.45 µM -0.795931478394423 0.219177887386151 no 2691 0.213035931838366 3730 6473636 YDL196W YDL196W
SGTC_822 1487-0950 154 µM -0.796145094442125 0.219115834009027 no 2692 0.212973853120462 3812 1958375
SGTC_982 1491-0518 27.5 µM -0.796564318115212 0.21899408299281 no 2693 0.21285205369253 3774 3091256
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.796600190879567 0.218983666625474 no 2694 0.212841633263834 3790 7104
SGTC_154 3389-1638 511.116 µM -0.797320047245254 0.218774702320677 no 2695 0.212632590165415 3790 5238686
SGTC_2584 androsterone 48.74 µM -0.798058778506489 0.218560378245163 no 2696 0.212418190587243 3831 2754130 A steroid.
SGTC_2541 muurolladie-3-one 83.07 µM -0.798282520238701 0.218495489134915 no 2697 0.212353279679554 3866 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_216 k038-0035 28.382 µM -0.803564672696235 0.216966795916942 no 2698 0.210824216230213 3750 4444231 YPR107C YTH1
SGTC_967 1306-0166 352 µM -0.804442770761776 0.216713268550809 no 2699 0.21057065413552 3786 4437607
SGTC_25 0118-0223 35.662 µM -0.808050443162128 0.215673449119018 no 2700 0.209530772097918 3846 5333628
SGTC_2461 5755302 26.15 µM -0.808307437209128 0.215599487679358 no 2701 0.209456811108264 3867 2788904
SGTC_2255 7941087 197.44 µM -0.810048622420495 0.215098771918295 no 2702 0.208956115575406 3854 935561
SGTC_1680 diphenhydramine 100 µM -0.811305348501224 0.214737792812871 no 2703 0.208595169660606 3871 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1375 2910-0797 186 µM -0.813121028289969 0.214216883292719 no 2704 0.208074335592253 3864 742508
SGTC_214 4373-3496 70 µM -0.813288796758261 0.214168788482652 no 2705 0.208026249393129 3921 3779166
SGTC_299 1273-0059 1.44 µM -0.814130230749747 0.213927666270711 no 2706 0.20778517454956 3772 2848077
SGTC_2286 7945697 125 µM -0.814583649375922 0.213797799706757 no 2707 0.20765533640027 3880 1245733
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.81555017271529 0.213521124794015 no 2708 0.207378728808477 3923 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1096 rimcazole 32.2 µM -0.816495455528401 0.213250732080482 no 2709 0.207108410822024 3787 18528119 A dopamine reuptake inhibitor.
SGTC_18 0111-0177 500 nM -0.81880130014788 0.212591996670511 no 2710 0.206449894520734 3908 721752
SGTC_3318 9139014 38.6185 µM -0.82011784594704 0.212216418472813 no 2711 0.206074464829213 3840 16643984
SGTC_2993 9054257 71.4286 µM -0.822169627492545 0.211631869470149 no 2712 0.205490181140747 3817 6470217 YGL055W OLE1
SGTC_2629 bisabolol 100 µM -0.823147037480039 0.211353738820781 no 2713 0.205212191377228 3890 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1671 st016596 74.5 µM -0.824071249859613 0.211090943067416 no 2714 0.204949537439961 3915 2829167
SGTC_2237 6667747 47.222 µM -0.824191320623854 0.211056815532349 no 2715 0.204915428942354 3853 729940 YDL015C TSC13
SGTC_189 3970-0742 2.116 µM -0.825914762383846 0.210567320705303 no 2716 0.204426222897518 3833 2891807
SGTC_2275 7947463 200 µM -0.827035728975313 0.210249299775525 no 2717 0.204108405370229 3802 1225414
SGTC_64 000l-0018 272.079 µM -0.828690508444815 0.209780350737211 no 2718 0.203639779005564 3811 6811119
SGTC_1400 3771-8998 51.5 µM -0.82881744367397 0.209744403891548 no 2719 0.203603858014286 3789 670767
SGTC_2393 9031399 185.94 µM -0.828958907820309 0.209704346862608 no 2720 0.203563829984042 3898 1526623 YDL150W RPC53
SGTC_1277 0873-0036 22 µM -0.829383425898955 0.209584167206882 no 2721 0.203443738520888 3926 5965735
SGTC_3253 9135987 49.47 µM -0.831396562559033 0.209014806719425 no 2722 0.202874820154534 3843 4182430
SGTC_433 pimozide 108 µM -0.832429717071902 0.208722961371082 no 2723 0.202583217019341 3804 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_3231 9132313 49.47 µM -0.83352833659761 0.208412887100995 no 2724 0.202273411694497 3871 4905967
SGTC_1217 1183-1422 255 µM -0.83445892820059 0.208150449668136 no 2725 0.202011211245826 3909 2849664
SGTC_2532 xanthone 78.9 µM -0.836722948378437 0.207512785149782 no 2726 0.201374158378714 3863 7020 An insecticide.
SGTC_3055 9094636 49.47 µM -0.836744793644703 0.207506638028399 no 2727 0.201368017401207 3882 25236176
SGTC_2063 5246145 200 µM -0.8384413867721 0.207029556159267 no 2728 0.20089142681372 3940 711240
SGTC_3069 9117009 49.47 µM -0.838596673600812 0.206985921956749 no 2729 0.200847838969937 3836 41904981
SGTC_871 0574-0004 149 µM -0.838643051939594 0.206972891116017 no 2730 0.200834822020081 3862 9551173
SGTC_862 0452-0056 10.2 µM -0.838674948355632 0.206963929517536 no 2731 0.200825869987048 3850 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1101 ebselen 5.29 µM -0.839314467656817 0.206784299006904 no 2732 0.200646433340077 3913 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2888 9058547 12.99 µM -0.840295934077112 0.206508800736227 no 2733 0.20037124028557 3808 16476514
SGTC_366 0181-0206 4.31 µM -0.84096923748416 0.206319929835831 no 2734 0.200182584154634 3855 274874
SGTC_378 3970-0959 8.33 µM -0.841187154133961 0.206258823142802 no 2735 0.200121547910748 3922 6615653
SGTC_324 1315-0088 19.6 µM -0.841484657508059 0.20617541660796 no 2736 0.200038238294894 3868 6787421
SGTC_955 1216-0110 33 µM -0.844370028973241 0.205367526417451 no 2737 0.199231332407233 3851 3619719
SGTC_2997 9067075 71.4286 µM -0.844577322434902 0.205309557725199 no 2738 0.199173437521563 3922 27209819
SGTC_2064 5220758 200 µM -0.848703435547094 0.204157732067428 no 2739 0.198023167025139 3972 788518
SGTC_1361 1608-0041 5.61 µM -0.849427568692289 0.203955984312551 no 2740 0.197821709085174 3854 X1361
SGTC_3265 9137266 49.47 µM -0.850897979941745 0.203546684794736 no 2741 0.19741301354733 3795 17224265
SGTC_3061 glucosamine 200 µM -0.851388604939915 0.203410224884007 no 2742 0.197276759778172 3789 91431 and experimental redox chemotherapeutic
SGTC_1397 3532-0190 20.1 µM -0.852505351625651 0.203099822289617 no 2743 0.196966834999653 3817 5322280
SGTC_977 1348-1378 135 µM -0.852733506939918 0.203036440745214 no 2744 0.196903552544524 3895 X977
SGTC_2902 5787006 60.46 µM -0.852774555195903 0.203025038793786 no 2745 0.196892168473521 3870 591003
SGTC_1758 st042942 75.2445 µM -0.853743017657011 0.20275614045103 no 2746 0.196623696668251 3833 669317
SGTC_3071 9117417 49.47 µM -0.854423122969787 0.202567433135704 no 2747 0.196435294254483 3845 45595590 YGL055W OLE1
SGTC_1926 methyl fluorone black 53.6 µM -0.858844408757617 0.201343230540285 no 2748 0.195213181530969 3696 72721 Reacts with homocysteine.
SGTC_1995 st072814 61.1 µM -0.859411448252807 0.201186545390547 no 2749 0.195056777903366 3908 5769371
SGTC_2646 retinol 96.75 µM -0.859673596076884 0.201114133056619 no 2750 0.194984496755167 3907 445354 A vitamin A analog and teratogen.
SGTC_2965 9082772 38.63 µM -0.863789761884033 0.199979187269843 no 2751 0.19385169653024 3913 16459634
SGTC_114 0364-0001 490.298 µM -0.863898326275514 0.199949305150697 no 2752 0.193821873179539 3981 4003655
SGTC_1573 oleylamine 1.06 µM -0.863915664927283 0.199944532972127 no 2753 0.193817110397146 3923 5356789 An amine of the fatty acid oleic acid.
SGTC_1149 3909-7961 23.3 µM -0.86429051925473 0.199841377234261 no 2754 0.193714158498183 3938 735261
SGTC_2318 6029776 164 µM -0.866353001418554 0.199274377902617 no 2755 0.193148304541333 3920 818325
SGTC_2053 5265679 138 µM -0.86782169347933 0.198871209291067 no 2756 0.192745976113564 3865 764595
SGTC_2736 butenafine 14.65 µM -0.869975760738857 0.198280789431438 no 2757 0.192156825416648 3876 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2357 9067248 200 µM -0.870304092360558 0.198190888265406 no 2758 0.192067121551378 3943 9150235
SGTC_2346 9031566 143.75 µM -0.871419693999593 0.197885606951616 no 2759 0.19176251822505 3904 4771086
SGTC_3117 9124945 49.47 µM -0.871551258076892 0.19784962353952 no 2760 0.19172661554263 3849 17592065
SGTC_2827 7993847 71.43 µM -0.871755134027591 0.197793870289799 no 2761 0.191670987716648 4003 2985692
SGTC_2570 licareol 100 µM -0.874331325037383 0.197090186406213 no 2762 0.190968922433977 3964 443158
SGTC_2130 NSC 7 2.4545 µM -0.876169169444301 0.196589108284267 no 2763 0.190469037178977 3995 21448
SGTC_1343 1487-0095 224 µM -0.876744958145382 0.196432281594 no 2764 0.190312590737215 3932 4560101 YGL055W OLE1
SGTC_406 estrone 100 µM -0.877052240704432 0.19634861855008 no 2765 0.190229131895134 3904 5870 A steroid.
SGTC_2891 9063876 19.48 µM -0.878132930201328 0.196054553563371 no 2766 0.189935792107442 3924 6472478
SGTC_335 4077-0256 27.6 µM -0.879875461809692 0.195580958603086 no 2767 0.189463389534015 3932 3121989
SGTC_2137 5261020 140 µM -0.882158094099701 0.194961624107343 no 2768 0.188845660005299 3913 763655
SGTC_3314 9135860 59.4275 µM -0.883158861831079 0.194690467548394 no 2769 0.188575222461749 3920 25252478
SGTC_2400 5203494 178.7 µM -0.884694874062464 0.194274733870344 no 2770 0.188160610534292 3876 6777674
SGTC_2787 5284540 71.43 µM -0.885047101488057 0.194179477023873 no 2771 0.188065614020351 4004 736958
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.886838725869695 0.193695388293225 no 2772 0.187582867372231 3941 16486 A toxic proline analog.
SGTC_885 0865-0106 16.8 µM -0.889893442134161 0.19287171661458 no 2773 0.186761552772682 3871 2793380
SGTC_432 NS 1619 61.3 µM -0.890854451906426 0.192613033637626 no 2774 0.186503629240571 4005 4552 A K+/calcium channel activator.
SGTC_1188 1403-0014 4.57 µM -0.891346850504203 0.192480572818333 no 2775 0.186371560859615 3968 9614867
SGTC_1383 3049-0032 20.7 µM -0.891547036092602 0.192426736546652 no 2776 0.186317884776732 4034 712864
SGTC_3348 9149464 3.537 µM -0.894093445312816 0.19174272978692 no 2777 0.185635948022561 3940 1951442
SGTC_1399 3562-5772 25 µM -0.895537088144221 0.19135560609364 no 2778 0.185250024504194 3893 23847490
SGTC_1478 0453-0656 35.7 µM -0.89776131388131 0.190760101548025 no 2779 0.184656406701621 3967 5258496
SGTC_2663 amphotericin b 100 µM -0.898752648162885 0.190495052801316 no 2780 0.184392213554959 3935 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2025 5147754 141 µM -0.898960681588076 0.19043946052509 no 2781 0.184336801975951 3946 315777 YLR208W SEC13
SGTC_2467 5474540 200 µM -0.903556754578647 0.189213805564373 no 2782 0.183115240542033 3927 5413519
SGTC_1709 st033179 39.1045 µM -0.904058153463407 0.189080389781196 no 2783 0.182982283049865 3938 573381
SGTC_3068 9116768 49.47 µM -0.905212294217735 0.188773508044505 no 2784 0.182676464967509 3944 41904888
SGTC_671 0560-0003 407 µM -0.905903884957053 0.188589763806249 no 2785 0.182493363933319 3873 3238678
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.906031413224814 0.188555893696966 no 2786 0.182459612907077 3766 4000243
SGTC_91 0417-1751 58.384 µM -0.906161352164099 0.188521387197773 no 2787 0.182425227894738 4081 6795624
SGTC_411 enrofloxacin 100 µM -0.907488678665751 0.188169126332644 no 2788 0.182074216846834 4079 71188 A bacterial gyrase inhibitor.
SGTC_665 3914-0008 307 µM -0.909360175411484 0.187673138079114 no 2789 0.181580018098935 3920 1069549
SGTC_3260 9137109 49.47 µM -0.910563409031761 0.187354681370906 no 2790 0.181262728753255 3911 17478346
SGTC_420 mitomycin C 81.9 mM -0.910819013629084 0.187287074212374 no 2791 0.181195371274902 3967 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3194 9111903 49.47 µM -0.914422999607491 0.186335429888824 no 2792 0.180247310552239 4023 17087251
SGTC_19 0279-0214 38.434 µM -0.914796935494406 0.186236862724043 no 2793 0.180149121951471 4041 3566274 YBR002C RER2
SGTC_2088 5278280 127.392 µM -0.915549883522464 0.186038488376924 no 2794 0.179951513711679 4053 791502
SGTC_993 3909-8757 62.7 µM -0.916506968793904 0.185786520471917 no 2795 0.179700527021077 3952 4288324 YLR208W SEC13
SGTC_3093 9117344 49.47 µM -0.924257469915399 0.183753883476135 no 2796 0.177676140157353 4050 24824913
SGTC_1825 st052143 62.6 µM -0.926036347553778 0.183289319245985 no 2797 0.177213545615629 4034 674173
SGTC_1644 st010134 20.9 µM -0.926812546563253 0.183086840078462 no 2798 0.177011934780991 3957 3818134
SGTC_2185 6113692 200 µM -0.929724321485621 0.18232851913541 no 2799 0.176256919198335 4013 874150
SGTC_2744 captopril 92.04 µM -0.929757666776187 0.182319846318442 no 2800 0.176248284671977 4020 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2311 7694451 200 µM -0.930647149292647 0.182088594891229 no 2801 0.176018058299318 3980 2163142
SGTC_565 1418-0001 44.5 µM -0.931287862147778 0.18192213332004 no 2802 0.175852339460747 4081 2862145
SGTC_1631 benzylvanillin 81.9 µM -0.932158447284129 0.181696101925904 no 2803 0.175627323125604 4093 75506
SGTC_3150 9097574 49.47 µM -0.934840482153174 0.181000866118553 no 2804 0.174935256751166 4045 17217476
SGTC_8 0354-0001 70 µM -0.936044143460216 0.180689396237334 no 2805 0.1746252300028 4016 4993152
SGTC_3278 9139605 49.47 µM -0.937358626908381 0.180349633207618 no 2806 0.174287057622007 4064 7958859
SGTC_1729 st035615 45.989 µM -0.937790803883208 0.180238013255168 no 2807 0.17417596398074 4056 17385451
SGTC_3195 9113082 49.47 µM -0.93921847247534 0.179869592255178 no 2808 0.173809293337098 3958 17018038
SGTC_140 0062-0056 502.533 µM -0.939880270324983 0.179698970730598 no 2809 0.173639489291335 3951 3758964
SGTC_2186 6124449 200 µM -0.939968513981429 0.179676227863618 no 2810 0.173616855718065 4016 3834182 YLR033W RSC58
SGTC_385 1494-0393 12.4 µM -0.941656040612805 0.179241652938218 no 2811 0.173184384063007 4012 3090647
SGTC_2331 7980721 200 µM -0.942937684222562 0.178912043807647 no 2812 0.172856389059851 3994 2981221
SGTC_2329 6138490 200 µM -0.944636339230871 0.178475777222538 no 2813 0.172422284017784 4158 720019
SGTC_88 0180-0332 8.668 µM -0.944963662674127 0.178391787615792 no 2814 0.172338713838397 4086 3101745
SGTC_466 geldanamycin 89.2 µM -0.947345358076015 0.177781406154914 no 2815 0.171731412485836 3947 5288382 HSP90 inhibitor.
SGTC_1094 duloxetine 25.4 µM -0.948106985117231 0.177586494542444 no 2816 0.171537496305647 4017 60834 A selective serotonin reuptake inhibitor.
SGTC_2052 5265182 7.135 µM -0.950602266386494 0.176948860358417 no 2817 0.170903158852407 4041 1239884
SGTC_2983 9022671 12.99 µM -0.951208803268385 0.176794087198168 no 2818 0.17074919523332 4054 6405161
SGTC_166 k072-0058 166.424 µM -0.953145091602774 0.176300567341732 no 2819 0.170258281128906 3956 5846229
SGTC_1793 st048256 72.231 µM -0.957250332329072 0.17525711304335 no 2820 0.169220458954764 3908 672022
SGTC_1834 st055981 52.8 µM -0.957847804085097 0.175105577094392 no 2821 0.169069754846121 4070 471719 YDL150W RPC53
SGTC_1716 st033144 30.6155 µM -0.957989537523855 0.175069641635629 no 2822 0.169034017170265 4037 674617
SGTC_1221 2958-7315 257 µM -0.95837876334054 0.174970980393316 no 2823 0.168935899967172 4064 4562705
SGTC_1685 st024049 53.0905 µM -0.958926934286487 0.174832089468906 no 2824 0.168797777462419 4066 1941139
SGTC_1216 1165-0504 9.65 µM -0.959177601792309 0.174768600775382 no 2825 0.168734641014575 4079 6304004
SGTC_3215 9129942 49.47 µM -0.959308000111791 0.17473557947031 no 2826 0.168701803163273 4029 17682944
SGTC_3292 9120825 59.784 µM -0.959750544617257 0.174623541630326 no 2827 0.168590389018685 4044 24824900
SGTC_485 niflumic acid 177 µM -0.96141162624009 0.174203416966919 no 2828 0.168172620416374 4100 4488 A COX2 inhibitor.
SGTC_77 0828-0286 12.516 µM -0.962583486455756 0.17390741410432 no 2829 0.167878293971979 3966 745345
SGTC_1206 3978-0017 132 µM -0.963175861514404 0.173757906503507 no 2830 0.167729638284181 4151 3873677
SGTC_199 4063-0024 41.6 µM -0.963805893360196 0.173598984578102 no 2831 0.167571625728352 4070 306215
SGTC_938 3126-1755 342 µM -0.965365560150508 0.173205965590042 no 2832 0.167180872539902 4053 1777771
SGTC_2910 7948405 25.97 µM -0.966713222337516 0.172866826149399 no 2833 0.166843707660874 3965 2971328
SGTC_2970 9090938 41.86 µM -0.968199138774181 0.172493385867984 no 2834 0.166472462475919 4136 17217104
SGTC_2682 pyrogallin 40.03 µM -0.968468015170606 0.172425866907855 no 2835 0.166405342729131 4062 822798 An ATP competetive kinase inhibitor.
SGTC_3044 9093193 49.47 µM -0.969259372151859 0.172227242948157 no 2836 0.166207897306224 4091 25236277
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.969982816342902 0.172045792324533 no 2837 0.166027528741741 4098 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3170 9103054 49.47 µM -0.972501446267442 0.171415034640705 no 2838 0.16540057286576 4056 16432970
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.972873667104725 0.171321942352408 no 2839 0.165308046998474 4060 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2716 st080858 38.6235 µM -0.973181297773773 0.17124502843909 no 2840 0.16523160210284 4034 5296050
SGTC_2104 5389443 200 µM -0.974681617932032 0.17087023440295 no 2841 0.164859106950893 4111 2244536
SGTC_399 oxolinic acid 75 µM -0.975783089476035 0.170595410871432 no 2842 0.16458598327318 4028 4628 A DNA gyrase inhibitor.
SGTC_3262 9137218 49.47 µM -0.97816068200548 0.170003153074925 no 2843 0.163997429594195 3934 17650664
SGTC_2670 beta-carotene 100 µM -0.979485971193971 0.169673596594527 no 2844 0.163669958469783 3992 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_808 0711-0032 135 µM -0.981387727928332 0.169201407735249 no 2845 0.163200787807379 3983 4252555
SGTC_1791 st048313 56.1 µM -0.983033438893904 0.168793474326083 no 2846 0.162795490692358 4074 1204976
SGTC_2361 9034121 116 µM -0.986035654177027 0.168050924584311 no 2847 0.162057808541847 4067 6496917
SGTC_3081 9117243 49.47 µM -0.98643475919302 0.167952370908729 no 2848 0.161959907606323 4061 45595589
SGTC_2278 7948257 134.34 µM -0.986962490080449 0.167822111915342 no 2849 0.1618305137569 4078 1247028
SGTC_3048 9093155 49.47 µM -0.987756147083994 0.167626337292068 no 2850 0.161636044587853 4037 25236002
SGTC_3218 9131285 49.47 µM -0.988750976789964 0.167381146414748 no 2851 0.161392497455157 4038 17156417
SGTC_3042 9091578 49.47 µM -0.990149303840402 0.167036898432276 no 2852 0.161050573789577 4057 25236497
SGTC_1084 voriconazole 435 nM -0.990468292033278 0.166958432133019 no 2853 0.16097263998569 4090 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.991216871924932 0.166774386106452 no 2854 0.160789846889905 4080 77254
SGTC_1224 0823-0416 294 µM -0.991319074659386 0.166749268677854 no 2855 0.160764900882073 4150 3598164
SGTC_1540 guanosine 70.6 µM -0.99158984417061 0.166682735938604 no 2856 0.160698822711678 3956 6802 Guanosine is a purine nucleoside
SGTC_2316 5844804 197.44 µM -0.991939898781297 0.166596746875842 no 2857 0.160613422219891 4102 776813
SGTC_2477 5967686 25.23 µM -0.992861279050275 0.166370551573564 no 2858 0.160388780935154 4070 776118
SGTC_247 mechlorethamine 29.705 µM -0.993585219389639 0.16619296619835 no 2859 0.1602124214855 3967 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1799 st045822 46.1415 µM -0.995965000646458 0.165610059790939 no 2860 0.159633575432392 4055 3674992
SGTC_1106 tegaserod maleate 11.7 µM -0.996439130283051 0.165494084064036 no 2861 0.159518414222908 4089 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1828 st055811 49 µM -0.997366198533644 0.165267467923535 no 2862 0.159293396044129 4116 5877589
SGTC_2112 5488546 200 µM -0.99819007557292 0.165066244854183 no 2863 0.159093598983234 4049 600757
SGTC_2505 galangin 7.89 µM -1.00134064024192 0.164298217178656 no 2864 0.158331075689695 3975 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3235 9132602 49.47 µM -1.00144309622773 0.164273279973106 no 2865 0.158306318846844 4104 4912240
SGTC_1022 4477-0945 21.3 µM -1.00217619724599 0.164094918957962 no 2866 0.158129250873343 4047 4648966
SGTC_2341 7987486 176.74 µM -1.00226811912523 0.164072563539788 no 2867 0.158107057895683 4133 1258686
SGTC_663 1486-0733 13.9 µM -1.00232697206794 0.164058251530574 no 2868 0.15809284992507 4115 722445 YPR165W RHO1
SGTC_1861 st057647 17.4 µM -1.00234182770841 0.164054639025926 no 2869 0.15808926368627 4172 688668
SGTC_394 menadione 8.33 µM -1.00318100707935 0.163850656261919 no 2870 0.157886767569117 4078 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_377 3970-0964 33.1 µM -1.00379048533109 0.163702611117909 no 2871 0.157739805736408 4047 16481235
SGTC_566 0958-0068 16.5 µM -1.00418609673114 0.163606561731879 no 2872 0.157644461141934 4004 6815365
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.00819692498373 0.162634850467017 no 2873 0.156679966919012 4162 6710655
SGTC_1421 4029-0249 71.4 µM -1.00924645955745 0.162381198703369 no 2874 0.156428225153235 4161 2894095
SGTC_2246 7293507 91.5585 µM -1.01121703468649 0.161905645616139 no 2875 0.155956282207087 4144 887656
SGTC_1079 idarubicin 2.36 µM -1.01234056935892 0.161634912858631 no 2876 0.155687621774939 4119 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2711 st079103 59.1 µM -1.01326442620272 0.161412516724706 no 2877 0.155466937260168 4055 54693780
SGTC_1333 1482-0047 286 µM -1.0155934972977 0.160852735430711 no 2878 0.154911501360918 4116 3811116
SGTC_156 3474-0145 5.642 µM -1.01722813586169 0.160460615545719 no 2879 0.154522457148578 3926 2265471
SGTC_3101 9120531 49.47 µM -1.017265266675 0.160451715803313 no 2880 0.154513627517673 4130 24824904
SGTC_1280 0880-0253 10.1 µM -1.0172995047436 0.160443509697612 no 2881 0.154505486071045 4096 6836607
SGTC_2496 diffractaic acid 79.83 µM -1.01995312364399 0.159808330361773 no 2882 0.153875346520286 4139 94870 An apoptosis inducer which activates caspases.
SGTC_2783 7738165 71.43 µM -1.02002866804379 0.159790271910109 no 2883 0.153857432362943 4102 17201110
SGTC_2309 7664088 163.95 µM -1.02092864309473 0.159575240772979 no 2884 0.153644123715323 4133 704922
SGTC_1409 3909-8004 61.9 µM -1.02097171421233 0.159564954537182 no 2885 0.153633920075719 4113 2119279
SGTC_1291 0993-0025 5.79 µM -1.02163615504498 0.159406327895925 no 2886 0.153476569475521 4125 4353356
SGTC_2004 4023728 41.89 µM -1.02289757435402 0.15910546453296 no 2887 0.153178138251741 4102 360084 YDR527W RBA50
SGTC_651 3253-0966 34.4 µM -1.02446283404155 0.15873264919345 no 2888 0.152808358369706 4127 781462
SGTC_3291 9121177 71.43 µM -1.02730125254245 0.158058053503263 no 2889 0.152139316387929 4136 17015612
SGTC_2432 5630864 12.22 µM -1.02736871959843 0.158042041807291 no 2890 0.15212343747022 4169 5714970
SGTC_2955 9076254 12.21 µM -1.02750054191797 0.158010759997913 no 2891 0.152092415196351 4045 16459619
SGTC_575 k072-0246 11.9 µM -1.02869382605872 0.15772777525065 no 2892 0.151811786023747 4194 6796779
SGTC_2296 7971656 126.45 µM -1.03169618663063 0.157017245377461 no 2893 0.151107232198964 4172 666570
SGTC_946 3434-1334 87.4 µM -1.03299946686146 0.156709471237953 no 2894 0.1508020740774 4115 4047976
SGTC_1984 st072354 53.1 µM -1.03303104188295 0.156702019617082 no 2895 0.15079468599986 4006 5762938
SGTC_105 0111-0055 734.78 µM -1.03504881911263 0.156226313223478 no 2896 0.150323056371068 4134 5179370
SGTC_2187 6125751 200 µM -1.03519547894031 0.156191774176226 no 2897 0.150288814871613 4142 874498
SGTC_2814 7977482 42.97 µM -1.0387334559386 0.155360089373014 no 2898 0.149464358499645 4188 6456762
SGTC_2598 perillyl alcohol 100 µM -1.04079158767614 0.154877624019156 no 2899 0.148986142574379 4175 10819 An apoptosis inducer.
SGTC_323 4013-0906 34.3 µM -1.04254589059141 0.154467164066248 no 2900 0.148579330455543 4135 2910086
SGTC_1132 3456-3614 2.5 µM -1.04483788244852 0.153931983741426 no 2901 0.148048951567399 4207 3125502
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.04642338548408 0.153562487463305 no 2902 0.147682800216936 4177 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2151 5563267 85.4165 µM -1.04700294802051 0.153427569026103 no 2903 0.147549109264281 4182 5310824
SGTC_1944 st076371 56.9 µM -1.05078384344869 0.152549328268678 no 2904 0.146678938916108 4116 24208455
SGTC_135 0933-0004 26.348 µM -1.05114093135461 0.152466555268805 no 2905 0.14659693373053 4121 21230617 YGL099W LSG1
SGTC_685 1278-0033 54.9 µM -1.05141522080764 0.152402995199221 no 2906 0.146533964096087 4217 3590572
SGTC_1049 3226-0134 66 µM -1.05168041351783 0.152341559807067 no 2907 0.146473100098263 4184 5702385
SGTC_2819 7996655 46.38 µM -1.05537510214967 0.151487346461806 no 2908 0.145626902649412 4098 6456960
SGTC_2140 5586273 200 µM -1.05677990843212 0.151163391981327 no 2909 0.14530602293781 4110 854421
SGTC_2481 5478948 45.16 µM -1.05680196980021 0.151158308211807 no 2910 0.145300987573137 4193 77792
SGTC_295 k015-0027 31 µM -1.059514969137 0.150533998104214 no 2911 0.144682657818658 4185 3887424
SGTC_3073 9114972 49.47 µM -1.06040408654499 0.150329770348052 no 2912 0.144480401931305 4154 41905075
SGTC_1912 st060209 90.8 µM -1.06054354274208 0.150297754411961 no 2913 0.144448695813157 4155 688787
SGTC_2914 7968218 45.32 µM -1.06324638331732 0.149678141815993 no 2914 0.143835116452353 4119 2977111
SGTC_233 rapamycin 362 pM -1.06385382411234 0.149539123955555 no 2915 0.143697461973235 4142 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_784 4579-0127 173 µM -1.06444843818048 0.149403125081828 no 2916 0.143562800338345 4205 1948547
SGTC_3283 9109332 35.8195 µM -1.06462798520175 0.149362075700833 no 2917 0.143522155258345 3994 17027281
SGTC_2748 diazoxide 86.69 µM -1.06506162939485 0.149262963782585 no 2918 0.143424020796067 4213 3019 A potassium channel activatior.
SGTC_1698 5-fluorocytosine 1.055 µM -1.06724493383867 0.148764624032159 no 2919 0.142930623417033 4174 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1023 4482-3888 16 µM -1.06764412627388 0.148673628650322 no 2920 0.142840535490965 4192 3303168
SGTC_988 1497-1057 103 µM -1.0677867936331 0.148641116843275 no 2921 0.142808348283933 4124 3533044
SGTC_1523 st012844 44.7 µM -1.06919540864376 0.148320369199802 no 2922 0.14249081358492 4264 4274103
SGTC_1913 st060213 96.1 µM -1.06995734386251 0.148147066390154 no 2923 0.142319254762568 4207 688959
SGTC_789 1309-1135 70.6 µM -1.07083920064592 0.147946656548424 no 2924 0.142120868707262 4146 3092424
SGTC_1642 st009582 77.7 µM -1.07303403429991 0.147448649225269 no 2925 0.141627923030251 4165 6739311
SGTC_1449 4112-4002 201 µM -1.07404684925545 0.147219220892214 no 2926 0.141400842264366 4223 2059539
SGTC_332 4112-0506 40.9 µM -1.07487366048754 0.14703210463617 no 2927 0.141215647979168 4121 2790355
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.07632021351414 0.146705117897954 no 2928 0.140892035781757 4177 688751
SGTC_578 3460-0051 92 µM -1.08166724782137 0.145500682838392 no 2929 0.139700205712498 4242 2876744
SGTC_1797 st048695 56.8 µM -1.08653890761887 0.144409132511753 no 2930 0.138620318504727 4142 592262 YIL048W NEO1
SGTC_139 0099-0334 718.624 µM -1.08802528695513 0.144077194032546 no 2931 0.138291972229021 4217 97690
SGTC_175 3793-3120 23.7 µM -1.08837109934541 0.144000040987199 no 2932 0.138215657175147 4196 5322297
SGTC_1827 berberine 7.24 µM -1.08993843864141 0.143650706545596 no 2933 0.137870131423379 4112 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_235 0330-0087 5 mM -1.09004671369099 0.143626594935508 no 2934 0.137846283567719 4207 46494818 YHR062C RPP1
SGTC_3346 9158254 43.5805 µM -1.09066985788632 0.143487880976579 no 2935 0.137709089178529 4187 17639500
SGTC_3181 9108277 49.47 µM -1.09147526304941 0.143308729152064 no 2936 0.137531905440019 4137 17097298
SGTC_2866 9034245 58.44 µM -1.09290073824856 0.142992021274708 no 2937 0.13721869206145 4155 6462273
SGTC_2746 daunorubicin 9.88 µM -1.09744693117343 0.141985122751705 no 2938 0.136223033671984 4136 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2506 ethyl hematommate 54.16 µM -1.10009288895302 0.141401306604313 no 2939 0.135645825919577 4264 3940691 An allergen.
SGTC_56 0957-0365 83.25 µM -1.10068257783117 0.141271416982724 no 2940 0.135517415702467 4170 6752360
SGTC_974 1326-0144 138 µM -1.10124174763292 0.141148324473976 no 2941 0.135395728259489 4225 5411856
SGTC_2121 5257820 149.641 µM -1.10204818548264 0.140970927868593 no 2942 0.135220361861271 4244 791256
SGTC_3324 9138759 60.749 µM -1.105331751882 0.140250185439495 no 2943 0.134507932176765 4249 45595710
SGTC_706 4262-0057 46.9 µM -1.10600273731045 0.140103212741229 no 2944 0.134362667292538 4205 883298
SGTC_3313 9133968 57.047 µM -1.10729152898179 0.139821209314826 no 2945 0.134083952805695 4196 1494643
SGTC_561 1550-0330 72.9 µM -1.10761281090497 0.139750969012624 no 2946 0.134014534172838 4146 6812934
SGTC_2977 9011197 71.43 µM -1.10984138278874 0.13926440753661 no 2947 0.13353369162409 4278 2704722
SGTC_3016 9080866 49.47 µM -1.11080624178315 0.13905410899621 no 2948 0.13332587959545 4178 17066299
SGTC_2745 rifampicin 24.3 µM -1.11391876624804 0.138377184017191 no 2949 0.132657018911396 4259 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1271 0832-2808 169 µM -1.11428931413302 0.138296745562949 no 2950 0.132577544886088 4239 3663794
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.11508242515288 0.138124684336134 no 2951 0.132407551013837 4219 5379071
SGTC_2879 9041815 71.43 µM -1.1164706509993 0.137823867598572 no 2952 0.132110363087772 4218 4942971
SGTC_1314 1222-0010 41.1 µM -1.1170039331575 0.13770842881226 no 2953 0.131996321744658 4214 3526027
SGTC_62 0180-0423 3.232 µM -1.12040496424009 0.136973765171158 no 2954 0.131270615224816 4177 30102 YGL099W LSG1
SGTC_1340 1486-1359 257 µM -1.12081487398278 0.136885400928995 no 2955 0.131183335763566 4132 4309068
SGTC_1969 st069479 40.1 µM -1.1217406846347 0.136685967327045 no 2956 0.130986356338702 4210 3895485
SGTC_3334 9142812 21.919 µM -1.12323059952969 0.136365434441159 no 2957 0.13066978495333 4219 45283678
SGTC_116 0155-0182 31.788 µM -1.12381983657584 0.136238810924924 no 2958 0.130544732213027 4117 771486
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.12818217306034 0.135303873815886 no 2959 0.12962149552824 4205 756377
SGTC_1172 0370-0043 85 µM -1.12880316132692 0.135171141900638 no 2960 0.129490439384624 4240 376585
SGTC_3183 9108214 49.47 µM -1.13209247250365 0.134469563633708 no 2961 0.128797779624662 4161 4974831
SGTC_1830 st055982 50.3 µM -1.13245179335119 0.134393075709697 no 2962 0.128722270229187 4189 455313 An antimicrobial agent.
SGTC_3149 9097855 49.47 µM -1.13450427798808 0.133956740050179 no 2963 0.128291540142761 4232 25236625 YMR079W SEC14
SGTC_2252 omeprazole 400 µM -1.13474573074806 0.133905473919288 no 2964 0.128240935245251 4198 4594 A proton pump inhibitor.
SGTC_3011 9081274 71.4286 µM -1.13914581136513 0.132973594141887 no 2965 0.127321171350002 4222 6625322
SGTC_3177 9107506 49.47 µM -1.13969880126459 0.132856794661508 no 2966 0.127205903377779 4181 8897194
SGTC_2603 homopterocarpin 100 µM -1.14116329099371 0.132547814552012 no 2967 0.126900988648563 4210 101795 A weak amylase inhibitor.
SGTC_1496 4469-0713 57.4 µM -1.14829713301957 0.131049788388604 no 2968 0.125422961133575 4215 746691
SGTC_441 propafenone 146 µM -1.15089380415773 0.130507431602007 no 2969 0.124887963534783 4227 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_916 4466-0038 42 nM -1.15250747720816 0.13017117297298 no 2970 0.124556299478929 4295 5722064 YGL116W CDC20
SGTC_1862 st057513 3.81 µM -1.15306958553648 0.13005418125419 no 2971 0.124440912056342 4225 5393163
SGTC_2737 bleomycin 30.5 nM -1.15460802385275 0.129734358009739 no 2972 0.124125489683636 4318 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_183 3914-0051 30.55 µM -1.15486005519998 0.12968201562333 no 2973 0.1240738696632 4277 1596232
SGTC_3230 9131665 49.47 µM -1.15582299532967 0.129482164951757 no 2974 0.12387678257582 4218 15943720
SGTC_2898 9056270 58.44 µM -1.1564286300454 0.129356579581318 no 2975 0.123752938285963 4234 19154699
SGTC_1379 2144-0755 36.5 µM -1.15661530910821 0.129317886541503 no 2976 0.123714782369307 4306 5392327
SGTC_2743 auranofin 4.32 µM -1.16771846713508 0.12703094576043 no 2977 0.121460172604441 4262 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2221 6807166 181.081 µM -1.16899513868749 0.126769802630873 no 2978 0.121202794995357 4227 674925
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.16994527653105 0.12657569473476 no 2979 0.121011495876579 4293 5393153
SGTC_1602 st001878 87.6 µM -1.17004968782487 0.126554376717574 no 2980 0.120990486848355 4244 595405 YLR310C CDC25
SGTC_969 1313-0238 134 µM -1.17037469901108 0.12648803406202 no 2981 0.120925106431284 4288 5212874
SGTC_3270 9137563 49.47 µM -1.17102658650646 0.126355041075701 no 2982 0.120794045351842 4242 17015724
SGTC_2906 7926292 26.41 µM -1.17223629446641 0.126108504166493 no 2983 0.120551100218921 4255 2966319
SGTC_2524 avocatin b 10.57 µM -1.17244614341627 0.126065771377572 no 2984 0.120508991387709 4244 6710748
SGTC_2933 9026794 32.47 µM -1.17400186617257 0.125749285143797 no 2985 0.120197139070422 4208 17586027
SGTC_2829 7992743 58.44 µM -1.17481209783042 0.125584676502285 no 2986 0.120034949506046 4258 16462845
SGTC_718 1130-0073 349 µM -1.17770148614161 0.124998885725617 no 2987 0.119457817118378 4291 6740020
SGTC_1064 honokiol 6.76 µM -1.1849439727274 0.123538950112856 no 2988 0.118019799898365 4294 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2953 9074162 66.49 µM -1.18913428913379 0.122699743334575 no 2989 0.117193413596822 4271 16451992
SGTC_164 4100-3994 89.624 µM -1.19187088241912 0.122153841063604 no 2990 0.116655938464801 4271 4615967
SGTC_2899 9053889 58.44 µM -1.19384251304187 0.12176159378241 no 2991 0.116269789122699 4256 6470052
SGTC_1334 1486-0610 236 µM -1.19414051707672 0.121702384260294 no 2992 0.116211503198574 4342 3742339
SGTC_124 0136-0217 7.121 µM -1.19712668296842 0.121110188963638 no 2993 0.115628590571867 4329 3976905
SGTC_278 4092-0821 23.9 µM -1.19826222173343 0.120885529782537 no 2994 0.115407474452691 4281 877900
SGTC_1088 bifonazole 369 nM -1.19870385725314 0.120798234240826 no 2995 0.115321558837295 4250 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2082 5219693 150 µM -1.19922886385544 0.120694516954672 no 2996 0.115219483397753 4267 2834649
SGTC_2212 7123476 200 µM -1.20006911779255 0.120528651701896 no 2997 0.115056249066847 4277 1085715
SGTC_2514 salinomycin 42.74 µM -1.20058829845511 0.120426246244033 no 2998 0.114955471186758 4340 23682228 A polyether potassium ionophore.
SGTC_2664 lyso-paf C-16 73.48 µM -1.20143197244777 0.120259967035562 no 2999 0.114791840011711 4243 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_529 4076-0302 30.3 µM -1.20361058772981 0.119831333382065 no 3000 0.114370062647138 4248 5816522
SGTC_205 1486-1330 71.903 µM -1.20363477995327 0.119826579715729 no 3001 0.11436538526341 4339 4118834
SGTC_14 0354-0009 295 µM -1.20445114847366 0.119666244804091 no 3002 0.114207626410364 4380 1713507
SGTC_735 3076-0345 636 µM -1.20456953070778 0.119643007081178 no 3003 0.114184762549187 4344 2888990
SGTC_1936 st074407 74.3 µM -1.20898240363617 0.118779056185792 no 3004 0.113334802851744 4324 809813
SGTC_2841 9004761 38.96 µM -1.2112870603245 0.118329607129875 no 3005 0.112892703101019 4263 2991039
SGTC_1270 0831-1170 17.3 µM -1.2119279886807 0.118204828650821 no 3006 0.112769973599381 4300 6764716
SGTC_3204 9114183 49.47 µM -1.21933152027329 0.116770221426464 no 3007 0.111359194878102 4282 17027248
SGTC_2444 5485484 36.41 µM -1.22083159291763 0.116481057533743 no 3008 0.111074894648656 4372 6790631
SGTC_3209 9113616 49.47 µM -1.22153467253652 0.116345702229543 no 3009 0.110941823026415 4357 16649353
SGTC_306 1672-3436 11.6 µM -1.22405078497176 0.1158622203068 no 3010 0.110466535056118 4329 6797378
SGTC_3176 9106582 49.47 µM -1.22597279046085 0.115493860973989 no 3011 0.110104457276602 4279 17018027
SGTC_2756 carbadox 75.1 µM -1.22853126831196 0.115004811607181 no 3012 0.109623799466101 4244 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_598 3937-0236 20.2 µM -1.22917819974524 0.114881385207882 no 3013 0.109502500315979 4370 1379313
SGTC_1258 0671-0043 57.1 µM -1.23053735058339 0.114622383282509 no 3014 0.10924797461102 4318 4298767
SGTC_2335 9018011 154.17 µM -1.23073381248013 0.114584979595961 no 3015 0.109211218738729 4303 6458208
SGTC_100 0086-0128 49.5915 µM -1.23117963464973 0.114500133312524 no 3016 0.109127843247747 4341 93297
SGTC_2439 5492030 7.2 µM -1.23335420838392 0.114086922130505 no 3017 0.108721820727743 4312 5722370
SGTC_2808 7946468 45.46 µM -1.23412136583474 0.113941401116981 no 3018 0.108578841540257 4295 2970879
SGTC_262 fenpropimorph 62.5 µM -1.23563282748694 0.113655081170452 no 3019 0.108297538298946 4325 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_754 3474-0146 171 µM -1.23593558645673 0.113597790497986 no 3020 0.108241253912134 4304 24762078
SGTC_2705 st078069 42.8 µM -1.23710846955879 0.113376041793949 no 3021 0.108023407927481 4351 1530061
SGTC_590 k048-0076 22.4 µM -1.23732838297103 0.11333449871583 no 3022 0.107982597376971 4338 6832814
SGTC_2741 miltefosine 3.04 µM -1.2392857068894 0.112965225788126 no 3023 0.107619855008087 4336 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2150 5556613 200 µM -1.24134036511869 0.112578514311958 no 3024 0.107240019551801 4342 743190
SGTC_2518 prenyletin 46.28 µM -1.25127977412518 0.110721147509754 no 3025 0.105416211024118 4334 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1457 k015-0032 57.3 µM -1.25136023944696 0.110706201185747 no 3026 0.105401538349514 4321 4302660
SGTC_2375 9072683 200 µM -1.25642925009364 0.109767552033906 no 3027 0.104480191097882 4396 16798029
SGTC_638 3970-0837 4.09 µM -1.2609961604343 0.108926782855483 no 3028 0.103655115250429 4315 4118451 YLR208W SEC13
SGTC_2764 methyldopa 94.69 µM -1.26345273072944 0.108476447301759 no 3029 0.103213262002972 4325 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_581 0958-0271 211 µM -1.26631084322682 0.107954189166869 no 3030 0.102700908191987 4344 4591145
SGTC_1024 4507-0395 26 µM -1.26645152774958 0.107928528955572 no 3031 0.102675736481349 4395 4201836
SGTC_1125 tnp00248 1.32998 µM -1.26681605614435 0.107862061085418 no 3032 0.102610534794683 4372 24207736
SGTC_887 0885-0007 9.62 µM -1.26747986052294 0.107741099161818 no 3033 0.102491880165298 4376 5719458
SGTC_2583 asiatic acid 100 µM -1.26834826845313 0.107583000889973 no 3034 0.102336803436592 4368 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_751 0833-0568 350 µM -1.26979742097133 0.107319547346578 no 3035 0.102078399818952 4361 6954252
SGTC_2566 crystal violet carbinol 226 nM -1.26986269620265 0.107307691373395 no 3036 0.102066771540415 4342 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2739 tacrine 100.86 µM -1.27073871235399 0.107148671479247 no 3037 0.101910809277259 4395 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2433 5607874 27.82 µM -1.27334398312899 0.10667675092192 no 3038 0.10144800282383 4307 2252428
SGTC_2828 7998861 71.43 µM -1.27345464405578 0.106656738990299 no 3039 0.101428378704776 4336 2988188
SGTC_3162 9099653 49.47 µM -1.27515795234954 0.106349054334896 no 3040 0.101126670311572 4325 25237511
SGTC_2545 solidagenone 89.61 µM -1.27552357136448 0.106283092766092 no 3041 0.101061993270317 4220 6708572 An anti ulcer agent
SGTC_2702 st077768 96.8 µM -1.27870597489215 0.105710200837827 no 3042 0.100500307437189 4317 6484119
SGTC_1036 k216-0215 33.5 µM -1.28287898518113 0.104962368881899 no 3043 0.0997672381747041 4297 622330
SGTC_66 0109-0187 42.4 µM -1.2854761835391 0.10449887098404 no 3044 0.0993129670532791 4221 759417
SGTC_2443 5493264 126.67 µM -1.28655237206681 0.104307248756667 no 3045 0.0991251767233755 4399 5340055
SGTC_1350 1495-0454 146 µM -1.28794454927445 0.104059740704303 no 3046 0.0988826331550987 4389 1069057
SGTC_1244 0416-0015 52.5 µM -1.28952860168206 0.10377863837768 no 3047 0.0986071897413279 4323 96201
SGTC_643 k048-0106 28.4 µM -1.29103323136256 0.103512140727439 no 3048 0.0983460772814761 4381 6763920
SGTC_1687 st020778 55.3625 µM -1.29274757563953 0.103209104500099 no 3049 0.0980491886524348 4371 4259299
SGTC_1194 1488-0194 225 µM -1.29295853832118 0.103171858222263 no 3050 0.098012699748662 4318 1391452
SGTC_1089 terbinafine 2.25 µM -1.29684117612432 0.102488105640688 no 3051 0.097342919869684 4376 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3350 9150499 3.57 µM -1.30151522469128 0.101669359334729 no 3052 0.0965410783350078 4358 4910996 YPR165W RHO1
SGTC_1906 st060206 94.7 µM -1.3039635241713 0.101242399685158 no 3053 0.0961230096760897 4396 5133468
SGTC_1600 coumarin 106 71.1 µM -1.30685525539214 0.100739794496913 no 3054 0.0956309374460424 4433 100336 A hepatotoxic, DNA x-linker.
SGTC_1766 st045414 44.774 µM -1.31222254705251 0.0998117455094679 no 3055 0.0947225282150745 4382 253960
SGTC_1200 1643-0193 18.4 µM -1.31250272989134 0.0997634716727897 no 3056 0.0946752827813933 4397 5403974
SGTC_2717 st081029 62.2815 µM -1.31282573200825 0.099707841497233 no 3057 0.0946208385633458 4348 5292846
SGTC_1004 4084-0029 199 µM -1.3135184588821 0.0995886106065725 no 3058 0.0945041525354743 4384 716894 YLR208W SEC13
SGTC_863 0466-0191 129 µM -1.31399747296591 0.0995062245273199 no 3059 0.0944235273176565 4430 765160 YPR165W RHO1
SGTC_2820 7989630 71.43 µM -1.31450383839303 0.0994191884366202 no 3060 0.0943383536195768 4399 2984098
SGTC_371 0195-0006 7.36 µM -1.3146536407709 0.099393450481706 no 3061 0.0943131668263002 4217 3928593
SGTC_1896 st058441 89 µM -1.31703501229348 0.0989849545100802 no 3062 0.0939134444029992 4394 688759
SGTC_2946 9065502 71.43 µM -1.32048164131925 0.0983959034034455 no 3063 0.0933371307731625 4220 16489101
SGTC_2616 abietic acid 100 µM -1.32069853845915 0.0983589203210112 no 3064 0.0933009508047466 4408 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2972 9093619 59.92 µM -1.32076224404195 0.0983480598307512 no 3065 0.0932903262343107 4326 25236256
SGTC_2634 4'-methoxyflavone 100 µM -1.32299070357854 0.0979687058460974 no 3066 0.0929192347018458 4384 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_3354 9151612 71.43 µM -1.32453423709149 0.0977065771617445 no 3067 0.0926628401288742 4385 27261949
SGTC_727 3032-0951 202 µM -1.3253969804862 0.0975602870418186 no 3068 0.0925197589914605 4422 3652836
SGTC_1294 1000-1494 117 µM -1.33122217242142 0.0965767466381896 no 3069 0.0915579589131583 4384 712797 YDL207W GLE1
SGTC_3031 9088762 49.47 µM -1.33194788672336 0.0964547272478657 no 3070 0.0914386568584314 4352 205253
SGTC_672 1441-0018 53.7 µM -1.33240156017753 0.096378505539097 no 3071 0.0913641348570868 4393 251141
SGTC_3054 9094397 49.47 µM -1.3423932884856 0.0947110006097348 no 3072 0.0897342548554156 4390 2598354
SGTC_1285 0929-0069 65.5 µM -1.34481890167739 0.0943094201432685 no 3073 0.089341862349733 4437 1206237
SGTC_2107 5363541 170.161 µM -1.34674207055342 0.0939919171430218 no 3074 0.0890316588309811 4346 244052
SGTC_1968 st069590 43.6 µM -1.3467615922817 0.0939886982783274 no 3075 0.0890285141283433 4363 6384066
SGTC_3155 9099265 49.47 µM -1.34745705127283 0.0938740797106107 no 3076 0.0889165384413539 4376 25236499
SGTC_2932 9016711 44.54 µM -1.34776096459342 0.0938240241737821 no 3077 0.0888676383638255 4399 7117328
SGTC_720 r052-1644 49.9 µM -1.35254341112027 0.0930389318696656 no 3078 0.0881007706562986 4416 1422863 YOR257W CDC31
SGTC_1249 0481-0015 10.2 µM -1.35327033110589 0.0929200261714661 no 3079 0.0879846419173126 4335 4227577
SGTC_2921 7974240 10.71 µM -1.35362506859076 0.0928620409107314 no 3080 0.0879280124672105 4480 2979074 YDR527W RBA50
SGTC_1615 st002656 86.5 µM -1.35425738956309 0.0927587483096512 no 3081 0.0878271376628036 4417 1584458
SGTC_50 0929-0078 56.389 µM -1.35511721874501 0.0926184275299502 no 3082 0.0876901067706817 4251 1377751
SGTC_61 0978-8327 98.565 µM -1.35606978770432 0.0924631553801559 no 3083 0.0875384822618237 4325 6150059 YHR072W ERG7
SGTC_1403 3909-7815 62.9 µM -1.35639513323837 0.0924101670430275 no 3084 0.087486740458675 4375 6615483
SGTC_1550 gossypolone 36.6 µM -1.35880739158179 0.0920179884069549 no 3085 0.0871038152329514 4444 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2142 5622915 118.518 µM -1.36000944463806 0.0918230224588631 no 3086 0.0869134675808053 4409 5322196
SGTC_1444 4112-3581 28 µM -1.36142641353993 0.0915935915580686 no 3087 0.0866894868130897 4486 2877249
SGTC_1027 k015-0025 8.67 µM -1.36440653739102 0.0911124464928372 no 3088 0.0862198257632491 4377 3598955
SGTC_1663 st014140 55.4 µM -1.36498962750145 0.0910185254560137 no 3089 0.0861281550650269 4472 4207120
SGTC_3320 9137005 35.139 µM -1.3694072141255 0.0903092961694531 no 3090 0.0854360102348049 4466 4908713
SGTC_2747 doxorubicin 7.63 µM -1.36944627094465 0.0903030440794585 no 3091 0.0854299094699308 4453 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_423 5-fluorouracil 457 µM -1.3705824241079 0.0901213129930789 no 3092 0.0852525825073478 4346 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2847 9005661 71.43 µM -1.37062678346777 0.0901142230964342 no 3093 0.0852456646457171 4459 2991449
SGTC_1273 0849-0096 14.1 µM -1.3728221144203 0.0897638638129692 no 3094 0.0849038270521367 4436 5286025
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.37310064835262 0.0897194842562031 no 3095 0.0848605297691787 4424 688798
SGTC_2738 aclarubicin 5.55 µM -1.37352446364376 0.0896519879281056 no 3096 0.0847946806855928 4449 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1351 1496-0003 46.5 µM -1.37670647728872 0.0891464295761711 no 3097 0.0843015076678853 4430 3891978
SGTC_2024 5144227 134 µM -1.37739464188298 0.0890373735489484 no 3098 0.0841951342825478 4399 3475211
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.37762692368959 0.0890005854035893 no 3099 0.0841592519584724 4411 688662
SGTC_2960 9079389 5.97 µM -1.38140533277614 0.0884037594489249 no 3100 0.0835771835661538 4404 16457355
SGTC_1503 4585-0012 61.3 µM -1.38378438921161 0.0880295040336779 no 3101 0.0832122422221467 4440 2922052
SGTC_277 nystatin 15.5 µM -1.38424533046493 0.0879571290114806 no 3102 0.0831416737474673 4430 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2213 7173844 200 µM -1.38500279324485 0.0878382918355909 no 3103 0.083025806630261 4420 892728
SGTC_1463 k081-0032 34.1 µM -1.3859815372282 0.0876849155864011 no 3104 0.0828762706052841 3962 977755
SGTC_798 1287-0182 476 µM -1.38649109754261 0.0876051429399164 no 3105 0.0827984983977125 4460 1649755
SGTC_1726 st035556 14.5795 µM -1.38862072591679 0.0872723315717407 no 3106 0.082474055773103 4467 5919439
SGTC_2288 7946289 167.31 µM -1.39109515230525 0.0868868229421739 no 3107 0.0820982873547763 4452 1246052
SGTC_3105 9121040 49.47 µM -1.3928217223466 0.0866185827538865 no 3108 0.0818368539664146 4379 41448907
SGTC_2693 st077581 40.7 µM -1.39659593700114 0.0860343763606688 no 3109 0.0812675563952871 4416 25238761
SGTC_3321 9137793 26.8275 µM -1.39672127735828 0.0860150257725167 no 3110 0.0812487016102633 4396 4904192
SGTC_1480 1070-0044 41.2 µM -1.40080793257464 0.0853858928539614 no 3111 0.080635757939079 4472 3124987
SGTC_941 3237-0776 460 µM -1.4047692267755 0.0847793550431798 no 3112 0.0800449563329613 4462 760008
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.40669656278989 0.0844854198413606 no 3113 0.079758692706495 4492 368090
SGTC_3124 9127567 49.47 µM -1.40741812762585 0.0843755719610773 no 3114 0.0796517194848004 4402 17592030
SGTC_2778 tioconazole 65.09 nM -1.41227389019285 0.0836391375830162 no 3115 0.0789346656010382 4335 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_93 0109-0045 59.227 µM -1.41249444134582 0.0836058033865851 no 3116 0.0789022131294217 4564 88733
SGTC_253 dyclonine 31.25 µM -1.41520187698853 0.0831974134395006 no 3117 0.0785046571822063 4531 3180 An oral anasthetic.
SGTC_3269 9137823 49.47 µM -1.43236030307264 0.0806440415205461 no 3118 0.0760203665960817 4387 17682936
SGTC_2473 5854593 8.94 µM -1.43238552378405 0.0806403324482847 no 3119 0.0760167595797727 4380 2872951
SGTC_3284 9108171 64.8615 µM -1.43528158929332 0.0802152801870383 no 3120 0.0756034359572683 4434 8687505
SGTC_226 1,3-diallylurea 8.28947 mM -1.43561109016437 0.0801670272080711 no 3121 0.0755565186152966 4414 74537 YKL182W FAS1
SGTC_780 0109-0199 192 µM -1.43563382337246 0.0801636989062093 no 3122 0.0755532824718884 4494 610414
SGTC_526 4469-0568 170 µM -1.44466343381729 0.0788499434821561 no 3123 0.0742762227980402 4412 2901964
SGTC_659 k018-0002 107 µM -1.45104391837414 0.0779315009873269 no 3124 0.0733838156115708 4437 6797879 YHR007C ERG11
SGTC_2523 spermine 47.74 µM -1.45219835500402 0.0777661957244197 no 3125 0.0732232299842829 4480 1103 A DNA binding polyamine.
SGTC_2644 guaiazulene 100 µM -1.45340983142724 0.0775930092013267 no 3126 0.0730549992009011 4497 3515 A coloring agent.
SGTC_341 1486-1430 230 µM -1.45561951664321 0.0772778782221609 no 3127 0.0727489148950192 4419 2054753 YPL210C SRP72
SGTC_1220 1838-0075 193 µM -1.45859357609689 0.0768552733186195 no 3128 0.0723385013675597 4407 5529645
SGTC_1461 k072-0203 53.8 µM -1.46830412853462 0.0754876631067153 no 3129 0.0710108149987746 4373 5418714
SGTC_364 0083-0097 67.7 µM -1.47412242822196 0.0746771593940949 no 3130 0.0702243154080174 4503 5207356
SGTC_2148 5546263 113.568 µM -1.47843958634352 0.0740800729401021 no 3131 0.0696450781307079 4502 792097
SGTC_3251 9135047 49.47 µM -1.48213146663381 0.0735723646890895 no 3132 0.0691526587789784 4530 17682963
SGTC_2919 7978188 46.38 µM -1.4847223280252 0.0732176604895437 no 3133 0.0688086972538132 4488 2980291
SGTC_2840 9008771 71.43 µM -1.48918153136439 0.0726102350734886 no 3134 0.0682197863795857 4429 2992978
SGTC_72 0744-0168 198.391 µM -1.49122837113938 0.0723327135888869 no 3135 0.0679507736794119 4383 677577
SGTC_2298 7976326 193.81 µM -1.49201791752878 0.0722258801593345 no 3136 0.0678472241248481 4440 2235818
SGTC_2382 9035899 200 µM -1.49251478969766 0.0721587104686768 no 3137 0.0677821215023936 4486 6462679
SGTC_2078 5212016 200 µM -1.4938991812587 0.0719718139728492 no 3138 0.0676009862450663 4391 1899708
SGTC_739 1486-1183 203 µM -1.49558196209571 0.0717451341904786 no 3139 0.0673813132865353 4487 4346692
SGTC_454 lyso-paf C-16 6.67 µM -1.5002756253733 0.0711157659308547 no 3140 0.0667715103121637 4517 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1606 st000094 49.2 µM -1.50581811976006 0.0703780477023377 no 3141 0.0660569352433832 4516 1242210
SGTC_1746 st038117 42 µM -1.50595644268259 0.0703597121596443 no 3142 0.066039177810437 4520 2898218
SGTC_542 3381-0244 89.3 µM -1.50756833007405 0.0701463174085169 no 3143 0.0658325216763389 4516 1112843
SGTC_2839 9003951 25.97 µM -1.51575056634702 0.0690707561740076 no 3144 0.064791218061277 4552 2990634
SGTC_1554 st069299 38.7 µM -1.52785424621701 0.0675030818481792 no 3145 0.0632743651354569 4464 24207999
SGTC_2771 fluoxetine 41.05 µM -1.53002832260873 0.0672244304610637 no 3146 0.0630048592548636 4502 3386 A selective serotonin reuptake inhibitor.
SGTC_958 1222-0007 33 µM -1.53009071017848 0.0672164473920475 no 3147 0.0629971386982778 4553 7312461
SGTC_742 0kpi-0133 140 µM -1.53039218351596 0.0671778814066452 no 3148 0.0629598412986773 4542 2728852
SGTC_1794 st048918 76.9 µM -1.53294666392464 0.0668517857867653 no 3149 0.0626444984862804 4486 672303
SGTC_291 SEC14.278 35.5 µM -1.53388960994501 0.0667317226936108 no 3150 0.0625284062559709 4530 1068044
SGTC_3010 9080089 71.4286 µM -1.53393988967371 0.0667253253832048 no 3151 0.0625222207041264 4514 17027233
SGTC_1215 3852-0577 11.2 µM -1.53478982886341 0.0666172556957841 no 3152 0.0624177309988684 4535 2884876
SGTC_3287 9117173 37.0625 µM -1.53582320899872 0.0664860440518764 no 3153 0.0622908729334109 4537 2789709
SGTC_501 nsc-95397 161 µM -1.53596964624616 0.0664674666331551 no 3154 0.0622729125296911 4513 262093
SGTC_2886 9058944 51.95 µM -1.53613395444161 0.0664466268429957 no 3155 0.0622527650781414 4471 4949929
SGTC_2935 9038016 29.96 µM -1.53847564125877 0.066150171916975 no 3156 0.0619661799658137 4471 6463195
SGTC_859 0439-0102 54.6 µM -1.54055371108217 0.0658879495655298 no 3157 0.0617127205368728 4566 610143
SGTC_2175 5807670 165.306 µM -1.54278913778576 0.065606771183451 no 3158 0.0614409729161288 4475 241186
SGTC_1488 4013-0813 75.9 µM -1.55634628581444 0.0639214016548641 no 3159 0.0598128852936921 4511 2910057
SGTC_1344 1488-0097 29.1 µM -1.55770212534184 0.063754718331923 no 3160 0.0596519382312219 4550 747966
SGTC_1171 0368-0077 21.4 µM -1.55887183343902 0.0636111893614041 no 3161 0.0595133590455115 4509 3239779
SGTC_987 1497-1013 404 µM -1.56594453731267 0.0627486834631848 no 3162 0.0586808010109169 4545 1676435
SGTC_1296 1068-0102 11.9 µM -1.57085897127154 0.0621547612463013 no 3163 0.0581077052846161 4535 767053
SGTC_945 3381-0768 11.3 µM -1.57256872264018 0.0619491646743057 no 3164 0.0579093573611245 4535 1126236 YIL048W NEO1
SGTC_1882 5615643 20 µM -1.57318909030291 0.0618746971950536 no 3165 0.0578375203534918 4509 2253075
SGTC_2803 7707263 71.43 µM -1.5736600832888 0.0618182069739598 no 3166 0.0577830273554453 4497 2199229
SGTC_605 1315-0399 119 µM -1.5769469747721 0.061425102021083 no 3167 0.0574038632570541 4600 24020461
SGTC_2645 abamectin 100 µM -1.57823107635505 0.0612720577957896 no 3168 0.0572562666982049 4483 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1251 0490-5699 265 µM -1.58189635386714 0.0608368544106462 no 3169 0.0568366167262851 4540 3883818
SGTC_2555 cholic acid 100 µM -1.58227409909615 0.0607921398825755 no 3170 0.0567935054490849 4504 6708657 Influences liver metabolism.
SGTC_1805 st050013 60.3 µM -1.58391010678417 0.060598778705781 no 3171 0.0566070885519512 4495 4037144
SGTC_2650 prasterone 100 µM -1.58451078014439 0.0605279054691551 no 3172 0.0565387652131811 4564 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2770 toltrazuril 17.5 µM -1.58673172749644 0.0602664197285929 no 3173 0.0562867086506744 4471 68591 Kills coccidiodes.
SGTC_2843 9000894 45.46 µM -1.58739597251406 0.0601883861060882 no 3174 0.0562114954507422 4525 2242070
SGTC_1086 cerivastatin 2.18 µM -1.5886563978806 0.0600405323742814 no 3175 0.056068993951512 4559 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_902 1120-0002 2.07 µM -1.5887777340586 0.0600263140991749 no 3176 0.0560552909412814 4526 3280475
SGTC_3202 9113761 49.47 µM -1.58925109546168 0.0599708704191039 no 3177 0.0560018574761071 4463 4798415
SGTC_639 0833-0042 114 µM -1.58966386064705 0.0599225569684893 no 3178 0.0559552969634894 4557 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2269 7935389 174.42 µM -1.58976482103014 0.0599107443716858 no 3179 0.0559439131347349 4542 97605
SGTC_2426 5582046 32.21 µM -1.60231625996793 0.0584563525684963 no 3180 0.0545428459296714 4532 2251934
SGTC_396 dithiazanine 1.25 µM -1.60247468274869 0.0584381741929561 no 3181 0.0545253408145281 4504 10578 An antihelmenthic.
SGTC_1097 itavastatin 7.23 µM -1.60276058806582 0.058405378945571 no 3182 0.0544937606087003 4567 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3090 9117696 49.47 µM -1.60840967649313 0.0577603505375002 no 3183 0.0538727418881983 4516 7923821
SGTC_285 1486-1325 46 µM -1.60891052430618 0.0577034337375899 no 3184 0.0538179539473261 4584 22310230
SGTC_1916 st067606 49.2 µM -1.60992593754956 0.057588176604895 no 3185 0.0537070128995578 4450 19590279
SGTC_217 ketoconazole 989 nM -1.6135315519687 0.0571803743417283 no 3186 0.0533145370406543 4358 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1158 4092-0494 91.8 µM -1.61425507848899 0.0570988165018606 no 3187 0.0532360547591273 4621 1148199
SGTC_1120 ficusin 1.78878 µM -1.61641563705826 0.0568558175011644 no 3188 0.0530022398805895 4551 6199 A DNA cross-linker.
SGTC_2308 7584454 197.62 µM -1.62040622577918 0.0564091362224323 no 3189 0.0525725216922597 4519 893577
SGTC_1773 st048542 73.5835 µM -1.62564366095913 0.0558270934236448 no 3190 0.0520127407463313 4534 3237138
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.62719290245704 0.0556558354197063 no 3191 0.0518480673408354 4505 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2263 7948595 193.29 µM -1.62837051493034 0.0555259360348699 no 3192 0.0517231728563652 4578 2971371
SGTC_694 1315-0438 43.2 µM -1.6290762831478 0.0554481993468945 no 3193 0.0516484356215842 4593 6793154
SGTC_3190 9110366 49.47 µM -1.63237480691164 0.0550860228087575 no 3194 0.0513002765002505 4565 17123768
SGTC_1166 k206-0078 225 µM -1.63463884835798 0.0548385155248107 no 3195 0.0510623893765522 4575 5404595
SGTC_2763 lisinopril 49.32 µM -1.63794639299596 0.0544785124387994 no 3196 0.0507164384780759 4472 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2257 7960413 200 µM -1.64144393970997 0.0540998650017864 no 3197 0.0503526475711566 4601 2974689 YIL048W NEO1
SGTC_1327 1436-0082 2.18 µM -1.647118941159 0.0534899195082241 no 3198 0.0497668003018978 4580 15992205
SGTC_2918 7977171 22.06 µM -1.64999720386194 0.0531826550528893 no 3199 0.0494717539811559 4558 2236483
SGTC_3111 9122088 49.47 µM -1.65415037895237 0.0527417575060872 no 3200 0.0490484810466188 4508 16876704
SGTC_803 4488-1585 147 µM -1.66439648111534 0.0516664392229738 no 3201 0.0480166114137606 4572 747204
SGTC_376 3970-0862 59.1 µM -1.66648985421599 0.051448900891946 no 3202 0.0478079436612724 4590 3135186
SGTC_3126 9127922 49.47 µM -1.68319010188332 0.0497394320390565 no 3203 0.0461691481682837 4535 45595682
SGTC_2046 4110841 106 µM -1.68688800902198 0.0493671041704678 no 3204 0.0458124440970149 4590 44119630 YMR134W ERG29
SGTC_2196 6573537 42.6665 µM -1.6931590197699 0.0487407898774762 no 3205 0.0452126013136824 4613 2903087
SGTC_623 k072-0108 16.9 µM -1.69347380067116 0.0487095194547163 no 3206 0.0451826588372959 4564 5382803
SGTC_2194 5927483 104.545 µM -1.69418219333851 0.0486392061796772 no 3207 0.0451153337174358 4618 760979
SGTC_1031 k035-0009 16 µM -1.6991178288849 0.0481515569057686 no 3208 0.0446484923710573 4619 5180959
SGTC_3261 9137475 49.47 µM -1.70740658594518 0.0473414222540278 no 3209 0.0438732535486574 4624 17027690
SGTC_513 4245-1575 41.7 µM -1.71358600803793 0.0467445880025964 no 3210 0.0433023925338429 4417 719745
SGTC_2199 6590217 200 µM -1.71435261488897 0.0466709686756337 no 3211 0.0432319927492258 4576 703109
SGTC_2466 5983409 37.09 µM -1.71836059919507 0.0462875844933648 no 3212 0.0428654311816759 4600 2879657
SGTC_1154 4088-0362 150 µM -1.72272174283856 0.0458732959109559 no 3213 0.0424694282299083 4614 6618304
SGTC_2420 aureobasidin a 50 nM -1.72565526787829 0.0455963045512227 no 3214 0.0422047250195919 4632 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2126 5251174 33.877 µM -1.72698657067059 0.0454710437247143 no 3215 0.0420850376679619 4572 790722
SGTC_489 paxilline 115 µM -1.72983105635212 0.0452043364440307 no 3216 0.0418302319985389 4564 105008 A toxic potassium channel blocker.
SGTC_1487 3970-0795 2.82 µM -1.73152958374297 0.0450456786775362 no 3217 0.0416786765681021 4651 3765103
SGTC_607 4491-0986 66.8 µM -1.73285291291558 0.0449223786661043 no 3218 0.041560907660602 4602 698981 YDR232W HEM1
SGTC_3205 9113483 49.47 µM -1.73397369266724 0.0448181636395272 no 3219 0.0414613755151894 4572 17018033
SGTC_667 1498-1044 59 µM -1.73556240030321 0.0446707722530025 no 3220 0.041320619535906 4597 6739982
SGTC_1772 st048439 82.2 µM -1.73977724326989 0.0442816338642755 no 3221 0.040949069934888 4642 2927068 YDL195W SEC31
SGTC_2204 7233102 200 µM -1.7468540335994 0.0436344129561161 no 3222 0.0403313304921337 4612 2172480
SGTC_884 0851-0618 334 µM -1.74743709528603 0.0435814301435284 no 3223 0.0402807737822652 4618 9642473
SGTC_3300 9124615 50.48 µM -1.75578983169643 0.0428281016523644 no 3224 0.0395621506289962 4606 24824903
SGTC_3040 9091894 49.47 µM -1.7578484213771 0.042644064348221 no 3225 0.039386651949295 4529 25236966
SGTC_3119 9125183 49.47 µM -1.75987702536412 0.0424633337612403 no 3226 0.039214329757907 4539 22695334
SGTC_26 0302-0163 425.158 µM -1.76948847644376 0.0416154426014973 no 3227 0.0384061960814349 4674 3100915
SGTC_2445 5742597 35.57 µM -1.77084377075305 0.0414969939168001 no 3228 0.0382933424717118 4622 1774255
SGTC_97 0535-0701 19.132 µM -1.77422288875635 0.0412028584349676 no 3229 0.0380131448091196 4537 2832013 YGL099W LSG1
SGTC_658 3253-0951 102 µM -1.77956042364974 0.0407416981300088 no 3230 0.037573963978265 4627 1184878
SGTC_786 4544-0069 423 µM -1.78071432979552 0.0406425538854768 no 3231 0.0374795654803217 4611 748821 YLR208W SEC13
SGTC_3297 9117502 71.43 µM -1.79428630544875 0.039491075167424 no 3232 0.0363837413895545 4640 7453720
SGTC_74 000s-0487 160.283 µM -1.79951425391542 0.0390546642865735 no 3233 0.035968685611984 4511 677548
SGTC_1039 k821-0043 94 µM -1.80567525768443 0.0385454137280402 no 3234 0.0354845398171935 4602 15992768
SGTC_2201 6605497 169.863 µM -1.81137587902243 0.0380790496308757 no 3235 0.0350413435866264 4614 670741
SGTC_766 1391-0721 126 µM -1.81173215532641 0.0380500563814032 no 3236 0.035013796299361 4641 1020919 YIL115C NUP159
SGTC_1590 st077108 57.8 µM -1.8182276267659 0.0375246140261255 no 3237 0.0345146745718917 4644 5489485
SGTC_2525 harmine 47.85 µM -1.82442798237117 0.0370285867966821 no 3238 0.0340436974035995 4650 5280953 A monoamine oxidase inhibitor
SGTC_817 1391-0715 46 µM -1.83919465741393 0.035868814957168 no 3239 0.0329432801078406 4628 1353946
SGTC_2791 5663188 71.43 µM -1.85185874057379 0.0348980420832328 no 3240 0.0320230550076841 4617 54690634
SGTC_182 3448-4371 550.524 µM -1.85347700993711 0.0347755614829148 no 3241 0.0319070091814131 4579 3491403
SGTC_2576 guaiol 23.12 µM -1.85528333648164 0.0346392646531163 no 3242 0.0317778882505856 4561 227829
SGTC_3116 9124943 49.47 µM -1.86049586001348 0.0342484104053204 no 3243 0.0314077018206692 4629 41905195 YPL160W CDC60
SGTC_2176 5809774 33.9695 µM -1.86856792316577 0.033650296761706 no 3244 0.0308414759924221 4586 2870539
SGTC_3128 9127691 49.47 µM -1.87490574000355 0.0331867326387268 no 3245 0.0304028461323652 4651 41316314
SGTC_310 1273-0058 1.06 µM -1.88026451521623 0.0327988941720548 no 3246 0.0300360184323612 4320 2734232
SGTC_968 1309-0633 340 µM -1.88621151903134 0.0323728652892249 no 3247 0.0296332284396856 4679 3761976
SGTC_2685 mycophenolic acid 18.85 µM -1.88693983766307 0.0323210055752294 no 3248 0.0295842090336285 4666 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1242 0402-0103 60.1 µM -1.88904397640151 0.0321715660144126 no 3249 0.0294429681635427 4585 432868
SGTC_2360 9040895 200 µM -1.89551043448214 0.0317158730826008 no 3250 0.0290124053367614 4670 4914414
SGTC_3139 9095020 49.47 µM -1.89744761518332 0.0315804022328063 no 3251 0.0288844431921123 4573 25236292
SGTC_1309 pyrazolanthrone 13.4 µM -1.8994473401558 0.0314410595601891 no 3252 0.0287528420859581 4660 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1666 st014829 29 µM -1.90989543033013 0.0307212687714239 no 3253 0.0280733392831905 4680 3858230
SGTC_2605 digitonin 300 nM -1.91201949052269 0.0305766193647399 no 3254 0.02793684708202 4636 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1866 st057638 64 µM -1.91279463765702 0.0305239722020442 no 3255 0.0278871739588267 4680 688802
SGTC_1300 1094-0077 113 µM -1.91725005011922 0.0302228195779038 no 3256 0.027603086170594 4655 5532636
SGTC_2669 eugenol 100 µM -1.91934787880954 0.0300818771216569 no 3257 0.0274701612274731 4690 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_344 k064-0035 6.43 µM -1.93058652296403 0.0293360595555271 no 3258 0.0267671029179326 4606 5088750
SGTC_1886 st057356 49.9 µM -1.93347916342117 0.0291466030268133 no 3259 0.0265885987442498 4665 24207747
SGTC_875 0709-0210 25.7 µM -1.94468335488056 0.0284223410392799 no 3260 0.0259065500440859 4665 6251364
SGTC_2476 5806916 10.51 µM -1.95707465117547 0.0276388446107421 no 3261 0.0251693461049169 4627 2870194
SGTC_1515 3460-0031 42.1 µM -1.95897342694349 0.0275203914044004 no 3262 0.0250579494333757 4660 2876596
SGTC_2407 paclitaxel 400 µM -1.96324001669387 0.0272557679221843 no 3263 0.0248091457980856 4668 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1332 1480-0653 17.5 µM -1.96854392441407 0.0269297703258467 no 3264 0.0245027436837909 4682 5749438
SGTC_1787 fluconazole 80 µM -1.96860350133696 0.026926127077402 no 3265 0.0244993200978075 4323 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_882 0843-0131 351 µM -1.97487075335985 0.0265451637310142 no 3266 0.0241414085771382 4697 5425421
SGTC_2853 9015042 58.44 µM -1.97961583268716 0.0262597323116547 no 3267 0.023873356278556 4605 6457456
SGTC_1769 st044406 64.4 µM -1.98011150597997 0.0262300645764418 no 3268 0.0238455002767469 4670 670903
SGTC_519 k048-0011 62.8 µM -1.98418722559153 0.0259871798500431 no 3269 0.0236174860461823 4675 6836379
SGTC_86 0417-1630 471.922 µM -1.98957744906656 0.0256688517915961 no 3270 0.0233187511789996 4695 3634867
SGTC_3144 9087057 49.47 µM -2.00048514701034 0.0250346608691661 no 3271 0.0227239510968332 4626 17249618
SGTC_747 3448-8087 38.7 µM -2.00976469491736 0.0245055234102658 no 3272 0.0222280495377403 4702 5168703
SGTC_227 fluconazole 33.516 µM -2.01004008862155 0.0244899644719134 no 3273 0.0222134730560087 4677 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_92 0063-0024 660.874 µM -2.02359060247317 0.0237345773779975 no 3274 0.0215061463829367 4732 3594437
SGTC_2619 obliquin 87.91 µM -2.02566457588339 0.0236207085243171 no 3275 0.021399584577136 4669 6708593 A bioactive alkalod. YER133W GLC7
SGTC_959 1222-0044 107 µM -2.03812641686842 0.0229461402219841 no 3276 0.0207686459532595 4690 6083612
SGTC_3033 9090887 49.47 µM -2.03989614582702 0.0228516723125287 no 3277 0.0206803353608961 4695 19325384
SGTC_2352 9027995 87.8 µM -2.04260104777943 0.0227079182664519 no 3278 0.0205459736552819 4665 2997347
SGTC_2863 9028737 58.44 µM -2.05861865101981 0.0218721842458757 no 3279 0.0197653923153134 4699 6460917
SGTC_2020 4017018 200 µM -2.07851332155451 0.0208704660109143 no 3280 0.0188310526093347 4692 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2032 5185112 25.99 µM -2.08795872476227 0.0204086449653414 no 3281 0.0184007790516482 4615 5718189
SGTC_1140 3229-1848 2.98 µM -2.08970117712694 0.0203244031035209 no 3282 0.0183223256047919 4695 2849525
SGTC_3142 9086498 49.47 µM -2.09847922452792 0.0199044827713834 no 3283 0.0179314166342924 4589 25236367
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -2.10507390916591 0.0195938727774393 no 3284 0.0176424374853071 4706 2724278 An inhibitor of dopamine biosynthesis.
SGTC_407 eburnamonine 100 µM -2.10604767957423 0.0195483587445959 no 3285 0.0176001054545207 4604 3195
SGTC_198 3454-2873 16.191 µM -2.10640626870838 0.0195316209226479 no 3286 0.0175845386191749 4719 710957
SGTC_2861 9024595 19.48 µM -2.11301437906405 0.0192253471182007 no 3287 0.0172997685910893 4698 16482810
SGTC_2123 5259487 200 µM -2.12556940569966 0.0186546821936179 no 3288 0.0167695646494636 4703 2173474
SGTC_1493 4348-0038 111 µM -2.13356818041094 0.0182986837881582 no 3289 0.0164390724964113 4721 800424
SGTC_1938 st074717 56.4 µM -2.13972259846279 0.0180287265504604 no 3290 0.0161885958173402 4627 17250979
SGTC_2367 9070478 135.38 µM -2.14188928044976 0.0179344988616498 no 3291 0.016101196334057 4673 572802
SGTC_2324 6149169 200 µM -2.15796735926076 0.01724830775007 no 3292 0.0154651848314432 4713 2888231
SGTC_858 0438-0351 2.77 µM -2.16746718568504 0.0168535059201254 no 3293 0.0150996245842892 4730 2799119
SGTC_1191 1487-1166 10.6 µM -2.16873220183746 0.0168015209355796 no 3294 0.0150515105579593 4714 3955771
SGTC_1665 st014639 11.4 µM -2.17064772356891 0.0167230649611836 no 3295 0.0149789058276399 4766 981133 YIL048W NEO1
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -2.17069380674658 0.0167211813528531 no 3296 0.0149771628348049 4708 3256 An antibiotic and ribosome inhibitor.
SGTC_264 promethazine 12.5 mM -2.18290997938875 0.0162282157117858 no 3297 0.0145212199946348 4624 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1720 st037298 9.481 µM -2.19476350991259 0.0157618379981754 no 3298 0.0140902831487904 4691 597396
SGTC_872 0588-0139 234 µM -2.21688672151556 0.0149221026525503 no 3299 0.0133154166839002 4713 2047100
SGTC_3330 9141424 71.43 µM -2.21960994918805 0.0148214444508442 no 3300 0.0132226281625587 4721 27261020
SGTC_94 0334-0113 514.748 µM -2.22240868790728 0.0147186041308464 no 3301 0.0131278493686683 4728 6795178
SGTC_3136 9095672 49.47 µM -2.25469667693728 0.0135758747506698 no 3302 0.0120761871958323 4650 17217380
SGTC_1255 0566-0045 221 µM -2.25572717213849 0.0135407011748079 no 3303 0.0120438613859451 4728 2788469
SGTC_1693 xanthone 101.9 µM -2.26292103669428 0.0132973394855536 no 3304 0.0118202786766039 4771 7020 An insecticide.
SGTC_2973 9094665 17.96 µM -2.29891148277637 0.0121357481766746 no 3305 0.0107549831147105 4702 25237061 YIL048W NEO1
SGTC_1303 1160-0052 261 µM -2.30194536865055 0.0120419764117453 no 3306 0.0106691266243631 4705 3562476
SGTC_11 0438-0307 1.3 µM -2.31536926845457 0.0116345697313918 no 3307 0.0102963659335115 4731 4011476
SGTC_2076 5212012 200 µM -2.31563068742535 0.0116267560980108 no 3308 0.0102892209123178 4753 604802
SGTC_2192 5915882 198.485 µM -2.32468798701618 0.0113588384746781 no 3309 0.0100443250496388 4751 2876149
SGTC_886 0866-0150 153 µM -2.33468547119224 0.0110693540810123 no 3310 0.00977992890269015 4755 271463
SGTC_2707 st078556 66.6 µM -2.36298571559729 0.0102844227533216 no 3311 0.00906418416578325 4711 17250899
SGTC_136 0097-0015 404.482 µM -2.36938724596937 0.010113755752577 no 3312 0.00890879348767787 4730 4861337
SGTC_2077 5212015 200 µM -2.37314312797678 0.0100147772241069 no 3313 0.00881871392442378 4720 780900
SGTC_347 4534-1311 26.2 µM -2.37643662600993 0.00992868067621405 no 3314 0.00874038197215644 4738 2862016
SGTC_2167 5876490 200 µM -2.40926109574911 0.00910531401332519 no 3315 0.00799242884690192 4737 686534
SGTC_1306 1185-0270 9.02 µM -2.4198399623752 0.00885300844643701 no 3316 0.00776366952930946 4771 1548076
SGTC_1748 st037455 53.6035 µM -2.43040394803522 0.00860719309897785 no 3317 0.00754100153864943 4731 580690
SGTC_2927 9011802 47.9 µM -2.4350380287172 0.00850126472699343 no 3318 0.00744511234619965 4716 43912568
SGTC_2547 epiafzelechin trimethyl ether 100 µM -2.43818531658489 0.00842997621006 no 3319 0.00738060225596145 4751 6708630 An antioxidant.
SGTC_95 0471-0001 561.058 µM -2.45360734534556 0.00808818828987111 no 3320 0.00707156599620337 4749 4015405
SGTC_184 1494-0393 24.714 µM -2.46033039176366 0.00794304252504995 no 3321 0.0069404582325042 4734 3090647
SGTC_2129 girgensonine 121.053 µM -2.5306140362675 0.00655752483054955 no 3322 0.00569315326013517 4739 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2967 9089538 49.85 µM -2.58358155496107 0.00565921033468049 no 3323 0.00488901731912891 4741 728216
SGTC_202 3594-0513 34.79 µM -2.62715952562957 0.00500389732529008 no 3324 0.0043050479246249 4795 708429
SGTC_801 0866-0028 10.1 µM -2.6337701839449 0.00491062665456907 no 3325 0.00422213109184987 4776 6849771
SGTC_973 1325-0077 65.9 µM -2.66617797509557 0.0044754283259017 no 3326 0.00383595332003635 4782 2835149
SGTC_1183 1254-0324 198 µM -2.67141629499779 0.00440841363528935 no 3327 0.00377659540410047 4779 5799357
SGTC_881 0833-0569 170 µM -2.73171030179846 0.00369916881130867 no 3328 0.0031503257683134 4784 5418700
SGTC_1315 1237-0019 3.69 µM -2.74709802342176 0.00353539739505043 no 3329 0.00300625808293164 4779 825140
SGTC_3306 9127676 59.7925 µM -2.79172289043251 0.00309663258470857 no 3330 0.00262141173713276 4759 41905287
SGTC_147 4466-0538 29.23 µM -2.80025100358238 0.00301859053470951 no 3331 0.0025531442217556 4765 6742687 YHR072W ERG7
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -2.8123555943893 0.00291086108321497 no 3332 0.00245900503449943 4768 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2543 pimpinellin 60.67 µM -2.82294184965191 0.00281949934758567 no 3333 0.00237926007993947 4739 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_144 4161-2749 112.381 µM -2.83640659750936 0.00270703621451651 no 3334 0.00228121605895579 4787 797501 YMR168C CEP3
SGTC_1519 esterone 74 µM -2.83713266105197 0.00270108853291299 no 3335 0.0022760346957332 4779 698 A steroid.
SGTC_2592 piperlongumine 83.33 µM -2.84995420325115 0.00259798420512594 no 3336 0.0021862762258248 4763 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1776 st049249 45.9 µM -2.88034530160038 0.00236765422966321 no 3337 0.00198619921469934 4789 1822314
SGTC_790 1575-0012 79.1 µM -2.90155579275016 0.00221802922008016 no 3338 0.00185657325761421 4789 378741 YLR208W SEC13
SGTC_35 0133-0054 64.071 µM -2.94024696185095 0.00196698403414606 no 3339 0.00163975371401765 4756 99677
SGTC_2754 granisetron 64.02 µM -2.95626816347155 0.00187080928244096 no 3340 0.00155693114228322 4765 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2608 thymoquinone 42.66 µM -3.00720025004478 0.00159277427090655 no 3341 0.00131833006248397 4779 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_910 3454-3003 490 µM -3.06688608396136 0.00131517408418492 no 3342 0.0010815063622801 4746 820824
SGTC_2859 9028643 45.46 µM -3.11493123964987 0.00112466503035944 no 3343 0.000919938969741693 4751 17151580
SGTC_290 2043-6722 48.1 µM -3.14933690525413 0.00100415737346738 no 3344 0.000818207107191302 4806 773758 YLR208W SEC13
SGTC_2550 chrysin dimethyl ether 71.87 µM -3.18069627006372 0.000904763097897682 yes 3345 0.000734607892326799 4789 88881 An O-methylated flavonoid and antioxidant.
SGTC_1900 st060200 72.8 µM -3.28719404796313 0.000630853218850023 yes 3346 0.000505955396606127 4796 688945
SGTC_1246 0422-0085 105 µM -3.3286652143591 0.000546687594318978 yes 3347 0.000436316154117605 4780 264295
SGTC_1257 0669-0121 16 µM -3.42229502038051 0.00039340907116065 yes 3348 0.000310474490001366 4789 4307855
SGTC_797 k781-0471 270 µM -3.52903322613049 0.000267747093952504 yes 3349 0.000208540380587429 4803 23738129
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -3.70119293057966 0.000140822685928303 yes 3350 0.000107294116900066 4799 551469
SGTC_1169 aniline yellow 25.8 µM -3.72274250617534 0.000129692537376282 yes 3351 9.85352378154093e-05 4806 6051 A DNA damaging agent.
SGTC_196 k015-0023 18.111 µM -4.09505173833184 2.92363972616838e-05 yes 3352 2.11037060487917e-05 4808 5211998
SGTC_2617 dihydrotanshinone i 20.83 µM -4.26779917325489 1.40249069888209e-05 yes 3353 9.87054616599912e-06 4794 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2061 5245884 80.95 µM -4.57558075000566 3.53817069201219e-06 yes 3354 2.37450371516899e-06 4810 573863
SGTC_2628 lathosterol 100 µM -5.07836301875258 3.0861155045071e-07 yes 3355 1.90350380955562e-07 4807 6710616
SGTC_2625 euphol 100 µM -5.28044803731653 1.08325235188842e-07 yes 3356 6.44341846733632e-08 4807 6708538 A triterpene alcohol.