SGTCid condition conc unit ICY1|YMR195W.score ICY1|YMR195W.strain.pval ICY1|YMR195W.strain.significant ICY1|YMR195W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1717 st033143 58.0435 µM 11.3924831000279 2.31998422968522e-32 yes 1 2.27906012361283e-30 4 674616
SGTC_251 melphalan 456.522 µM 6.37984002945354 1.85974121864964e-11 yes 2 8.86365306236097e-11 6 460612 A DNA alkylator.
SGTC_1723 st034307 2.5525 µM 5.79941391453092 8.93201207871718e-10 yes 3 3.32735447993986e-09 6 867466
SGTC_382 3229-0966 23.2 µM 4.30047652635219 3.91178798837949e-06 yes 4 8.52156123562018e-06 12 5722370
SGTC_780 0109-0199 192 µM 4.01011167768828 1.52005203502921e-05 yes 5 3.03450180442753e-05 10 610414
SGTC_394 menadione 8.33 µM 3.94704589349491 2.0181822329041e-05 yes 6 3.95606974624467e-05 32 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_608 k048-0125 159 µM 3.82320878327336 3.4800024711266e-05 yes 7 6.58630743825696e-05 34 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1746 st038117 42 µM 3.7470294089578 4.82816287565492e-05 yes 8 8.94705569137192e-05 39 2898218
SGTC_2327 6189656 200 µM 3.47678380711672 0.000147126451460053 yes 9 0.000253733415194296 35 5349088
SGTC_2176 5809774 33.9695 µM 3.43803452669869 0.000171575435723062 yes 10 0.000292976490476269 28 2870539
SGTC_2397 5161689 200 µM 3.43446298500383 0.000174010641201053 yes 11 0.000296864576780349 52 2259942
SGTC_24 0417-1663 219 µM 3.34039873939713 0.00025105805987753 yes 12 0.000418290910968701 37 4329390
SGTC_570 0987-0065 62.6 µM 3.32302190703472 0.000268386986293552 yes 13 0.000445239604625965 16 3104428
SGTC_1919 st067113 52.3 µM 3.3091002287315 0.000283067588989079 yes 14 0.000467981621595118 51 1268243
SGTC_133 0724-0033 378.92 µM 3.26304744757888 0.000337131083111041 yes 15 0.00055110532369354 50 280309
SGTC_282 k297-0036 65.7 µM 3.25727196054835 0.000344550935473278 yes 16 0.000562443007949 9 5061378
SGTC_217 ketoconazole 989 nM 3.16173327710755 0.000491531556316432 yes 17 0.000784165719149546 55 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_529 4076-0302 30.3 µM 3.08567470283942 0.000647976783475707 yes 18 0.00101545438233803 48 5816522
SGTC_420 mitomycin C 81.9 mM 3.02525575645813 0.000803725005908768 yes 19 0.00124211479878586 58 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_110 0850-0284 111.64 µM 3.00518442603744 0.00086265186880037 yes 20 0.00132709930094782 31 3906265
SGTC_234 nsc-17383 10.7 µM 2.95871456468277 0.00101463912157828 no 21 0.00154462548443119 60 408974
SGTC_2914 7968218 45.32 µM 2.94653233073336 0.00105835948761541 no 22 0.00160679411338033 34 2977111
SGTC_2638 epoxomicin 18 µM 2.90629490250969 0.00121533168771708 no 23 0.00182868287855795 74 9915668 A protesome inhibitor.
SGTC_112 phenothiazine 287.218 µM 2.8253355279469 0.00159747085525498 no 24 0.00236155644534596 52 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_401 neomycin 50 µM 2.80578572565204 0.00170484113281381 no 25 0.0025097029099514 52 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_565 1418-0001 44.5 µM 2.78823912679599 0.00180676082853786 no 26 0.002649770508452 92 2862145
SGTC_2954 9074818 52.69 µM 2.77952857593305 0.00185938745731471 no 27 0.00272189318210358 94 16648742
SGTC_791 1348-1292 225 µM 2.77456543194884 0.00188999283476781 no 28 0.00276377567928908 123 5437054
SGTC_3231 9132313 49.47 µM 2.7683036996908 0.00192925893426333 no 29 0.00281744597786899 50 4905967
SGTC_2048 5246248 200 µM 2.72156156045984 0.00224658862784781 no 30 0.00324871410828948 45 677046
SGTC_526 4469-0568 170 µM 2.70902349247528 0.00233939867546022 no 31 0.00337407806882104 98 2901964
SGTC_862 0452-0056 10.2 µM 2.6844402559519 0.00253151050125757 no 32 0.00363256833690608 88 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_116 0155-0182 31.788 µM 2.65347826394388 0.00279371577284095 no 33 0.00398334506947039 202 771486
SGTC_2401 5128683 200 µM 2.64521489280933 0.00286771919598042 no 34 0.00408195262200689 110 708373
SGTC_564 3555-0129 330 µM 2.62264933065405 0.00307889647522179 no 35 0.00436245115006398 47 563260
SGTC_479 n-linoleoylglycine 10 µM 2.60483842770568 0.00325535665262919 no 36 0.00459587971234859 67 6433346 An anti-infammatory.
SGTC_2890 9046729 58.44 µM 2.5727291781318 0.0035965962900012 no 37 0.00504500640270396 88 903329
SGTC_567 1080-0542 68.4 µM 2.57175391776585 0.00360744560012047 no 38 0.00505923925559438 77 5950415
SGTC_111 0083-0039 52.457 µM 2.55232091527171 0.00382984122235768 no 39 0.00535039525714182 33 759313
SGTC_745 0469-0705 296 µM 2.52689002366689 0.00413941254634317 no 40 0.00575387660337438 127 3486736
SGTC_3137 9097352 49.47 µM 2.51215603466139 0.00432884265978212 no 41 0.00599980095489675 160 44120435
SGTC_3296 9122258 64.045 µM 2.50743449314758 0.00439116475369571 no 42 0.00608055603509211 113 4730474
SGTC_38 0929-0051 58.268 µM 2.50536673464168 0.00441870970382383 no 43 0.00611622428166675 132 1379719
SGTC_1119 parthenolide 318.541 nM 2.49922224088538 0.00450147463017307 no 44 0.00622331138225535 174 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1117 retinoic acid 1.10837 µM 2.46047788796634 0.00505598191597924 no 45 0.00693760609237052 102 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2820 7989630 71.43 µM 2.4595745048001 0.00506960681414113 no 46 0.00695509110310424 100 2984098
SGTC_199 4063-0024 41.6 µM 2.45328320188475 0.00516540276111547 no 47 0.00707794205926263 73 306215
SGTC_3144 9087057 49.47 µM 2.44546419407108 0.00528670383999282 no 48 0.00723329062345507 113 17249618
SGTC_135 0933-0004 26.348 µM 2.42619909469754 0.0055964515650595 no 49 0.00762894865018584 137 21230617 YGL099W LSG1
SGTC_102 gallobenzophenone 83.616 µM 2.42031322493487 0.00569424767206132 no 50 0.00775357163940719 145 70837
SGTC_3344 9148862 3.898 µM 2.41944906688461 0.00570873300719464 no 51 0.00777201869774947 127 4905352
SGTC_2664 lyso-paf C-16 73.48 µM 2.41672434540635 0.00575462018095348 no 52 0.00783043603982147 123 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2697 mebhydrolin 72.4 µM 2.41451118790655 0.00579213269541878 no 53 0.00787816953536381 200 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_933 2914-0560 114 µM 2.40667092833131 0.00592677508864887 no 54 0.00804933425846825 141 463887
SGTC_1805 st050013 60.3 µM 2.40632349463275 0.00593280534331681 no 55 0.00805699432697958 92 4037144
SGTC_2331 7980721 200 µM 2.40380131666255 0.00597674503338397 no 56 0.00811279457021924 143 2981221
SGTC_1977 st070720 65.3 µM 2.40328109498803 0.00598584379542076 no 57 0.00812434602488935 106 682188
SGTC_875 0709-0210 25.7 µM 2.39528510040727 0.00612724815094077 no 58 0.00830372315553494 144 6251364
SGTC_3282 9108498 15.4605 µM 2.38503530800097 0.0063128334584634 no 59 0.00853874111330143 147 16459645
SGTC_857 0438-0306 1.35 µM 2.37484660771285 0.00650222711716442 no 60 0.00877812218625175 102 4686136
SGTC_1033 k072-0102 21.3 µM 2.37265767166958 0.00654356624929997 no 61 0.0088303118081809 165 5965931
SGTC_964 1287-0107 19.4 µM 2.35021443756953 0.00698101239083865 no 62 0.00938129916341977 175 51516812 YPR165W RHO1
SGTC_198 3454-2873 16.191 µM 2.31866770177918 0.00763948664996523 no 63 0.0102065305429811 131 710957
SGTC_732 3970-1727 52.7 µM 2.31617466377268 0.00769378301721595 no 64 0.0102743669792103 109 1275699
SGTC_1237 0330-0133 46.1 µM 2.31428294195984 0.0077352095801705 no 65 0.0103261034320789 135 X1237 YHR072W ERG7
SGTC_3291 9121177 71.43 µM 2.30430384089799 0.00795700583703031 no 66 0.0106027967541094 127 17015612
SGTC_1983 st071813 46.9 µM 2.30107064848865 0.00803005680768855 no 67 0.0106938190382722 134 11838595
SGTC_2063 5246145 200 µM 2.30089598888623 0.0080340198096169 no 68 0.0106987554480752 166 711240
SGTC_269 exalamide 29 µM 2.29799963202749 0.00809998884663598 no 69 0.0107809050352762 105 3316 A derivative of salicylamide.
SGTC_1749 st037932 54.2 µM 2.29379220530938 0.00819666753212506 no 70 0.0109012186863083 152 594497
SGTC_2121 5257820 149.641 µM 2.27664211813117 0.00860130965744843 no 71 0.0114038027954976 137 791256
SGTC_2654 protoveratrine a 100 µM 2.27181217523393 0.00871838536668302 no 72 0.0115489285862607 118 5702278 A heart drug and vasodilator.
SGTC_2819 7996655 46.38 µM 2.26458052883626 0.00889628938062677 no 73 0.0117692164492669 134 6456960
SGTC_249 wiskostatin 11.211 µM 2.26164183546324 0.00896948755187818 no 74 0.0118597705227303 122 2775510 A n-wasp and actin depolymerizer.
SGTC_631 k072-0230 41.5 µM 2.25973867364127 0.00901717328415752 no 75 0.0119187372754906 147 5773147
SGTC_329 k048-0121 21.3 µM 2.25086350137212 0.00924249407133129 no 76 0.012197092032757 147 6832902
SGTC_3347 9188721 44.724 µM 2.24416914642421 0.00941569397556676 no 77 0.0124107601855826 132 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_299 1273-0059 1.44 µM 2.2389907698416 0.00955161244127012 no 78 0.012578258367062 144 2848077
SGTC_2474 5321570 43.32 µM 2.20968342524785 0.0103536345777494 no 79 0.0135635704311546 145 2841384
SGTC_381 3461-2219 42.7 µM 2.20512509215553 0.0104835140489506 no 80 0.0137226588792155 172 2883159
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 2.20141347860056 0.0105903145749904 no 81 0.0138533828345618 198 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1778 st046819 58.9 µM 2.19006710337291 0.0109227016713594 no 82 0.0142596852957443 211 671715
SGTC_2753 fluvastatin 17.09 µM 2.18288347934335 0.0111378044449971 no 83 0.0145221959766183 194 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_997 3996-0078 137 µM 2.17961900937404 0.0112367652239408 no 84 0.0146428572626552 194 735687
SGTC_2144 5628481 200 µM 2.17955251213746 0.0112387889726348 no 85 0.0146453240701804 163 2818399
SGTC_132 0417-1715 25.805 µM 2.17039176865995 0.0115206288817953 no 86 0.0149885899220185 159 6769098
SGTC_2540 epiandrosterone 100 µM 2.16658950711315 0.0116394001167619 no 87 0.0151330840957158 268 441302 A steroid.
SGTC_590 k048-0076 22.4 µM 2.16482523641833 0.0116948707509779 no 88 0.0152005357032435 154 6832814
SGTC_2288 7946289 167.31 µM 2.15916402444194 0.0118744179004874 no 89 0.0154187219979363 212 1246052
SGTC_371 0195-0006 7.36 µM 2.15183530703532 0.0121103986808856 no 90 0.0157051639838074 145 3928593
SGTC_2399 5884133 200 µM 2.13939208386158 0.0125203800573321 no 91 0.0162019637601413 244 722445
SGTC_1295 1013-0063 9.78 µM 2.1293445799255 0.0128601434320764 no 92 0.0166128810086623 173 6826038
SGTC_1402 3909-7673 35.9 µM 2.1258405559439 0.0129804956028526 no 93 0.0167582689314298 183 5328014
SGTC_826 1683-5028 118 µM 2.11075386600183 0.0135098631413674 no 94 0.0173967366868935 175 722377
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 2.10348219436362 0.0137716021133012 no 95 0.0177118200755627 218 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_438 sphingosine 6.67 µM 2.10176298387554 0.0138341194350387 no 96 0.0177870215966392 157 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2407 paclitaxel 400 µM 2.09826844036612 0.0139619496212857 no 97 0.0179407193817571 232 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2650 prasterone 100 µM 2.0815672257963 0.0145870354673487 no 98 0.0186910088248958 101 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2950 9072895 21.46 µM 2.08125848807921 0.0145988138929462 no 99 0.0187051263062804 272 17332245
SGTC_1779 st039427 55 µM 2.06614321995454 0.0151855608986256 no 100 0.0194074791564329 251 1124498
SGTC_935 2996-0153 430 µM 2.06265088719727 0.0153239723619633 no 101 0.0195729046214073 172 23738523
SGTC_2588 indole-3-carbinol 100 µM 2.05753642154056 0.0155286281902868 no 102 0.0198173276082428 263 3712 Induces cell cycle arrest.
SGTC_1230 0170-0365 3.77 µM 2.05653858779784 0.015568828920592 no 103 0.0198653153992735 335 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_41 0478-0632 82.643 µM 2.05514102515056 0.0156252840584252 no 104 0.0199326926952729 251 3750424
SGTC_733 4069-0007 56.1 µM 2.05399969334537 0.0156715188574414 no 105 0.0199878606950369 309 5717425 YNL287W SEC21
SGTC_2825 7998094 58.44 µM 2.04027153764944 0.0162368998484134 no 106 0.0206616440121116 211 2987815
SGTC_3348 9149464 3.537 µM 2.02793506247464 0.0167597830520568 no 107 0.0212834380190136 206 1951442
SGTC_1705 st027868 56.3335 µM 2.02310525843589 0.0169683836788201 no 108 0.0215311482640854 181 292948
SGTC_1645 Cervolide 78 µM 2.01749786173768 0.0172133495372115 no 109 0.0218217919736837 162 23173 A fragrance.
SGTC_2067 5224629 34.075 µM 2.01712297179379 0.0172298342682706 no 110 0.0218413409578817 231 2835000
SGTC_179 1273-0063 6.77 µM 2.01139816403621 0.0174832470147345 no 111 0.0221417085622136 184 3108139
SGTC_3010 9080089 71.4286 µM 2.00334833312516 0.0178449572780859 no 112 0.0225699565045164 212 17027233
SGTC_2764 methyldopa 94.69 µM 1.99531394469502 0.0182123191836969 no 113 0.0230043249770789 227 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_84 0443-0269 128.823 µM 1.99308306082804 0.0183154594691631 no 114 0.0231261762697497 238 6150058
SGTC_705 1124-0212 310 µM 1.98213328574609 0.0188289438851092 no 115 0.0237321625077865 230 9554485
SGTC_331 k048-0133 24.5 µM 1.97616013257308 0.0191141796946271 no 116 0.0240683218202047 179 6813582
SGTC_3007 9078383 71.4286 µM 1.97485374298739 0.0191770509363218 no 117 0.0241423740322407 226 6496995
SGTC_230 MPP+ 141.667 µM 1.97421745823009 0.0192077363537311 no 118 0.0241785108522857 219 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_571 k831-0106 44.2 µM 1.94976270597814 0.0204191218608578 no 119 0.025602204261289 215 4783639
SGTC_2479 5617353 43.85 µM 1.93885416780689 0.0209800188926285 no 120 0.0262595490564574 266 2731746
SGTC_2803 7707263 71.43 µM 1.9376490956922 0.021042773835212 no 121 0.02633302416062 225 2199229
SGTC_3244 9134489 49.47 µM 1.91817716245329 0.022079010205113 no 122 0.0275442754851716 244 16584271
SGTC_2177 5811945 192 µM 1.91734254604807 0.0221243719954335 no 123 0.0275972140633693 239 5343475
SGTC_672 1441-0018 53.7 µM 1.91466406172511 0.0222704804707569 no 124 0.0277676797964264 227 251141
SGTC_33 0986-0033 35.816 µM 1.91294712228161 0.0223645652042763 no 125 0.0278774110759233 193 2848082
SGTC_1163 k060-0048 49.9 µM 1.90274609175847 0.0229305000696597 no 126 0.0285368422465887 277 6809982
SGTC_1540 guanosine 70.6 µM 1.89410741715243 0.0234191470404148 no 127 0.029105376714403 207 6802 Guanosine is a purine nucleoside
SGTC_3016 9080866 49.47 µM 1.88915600346687 0.0237031534528027 no 128 0.0294354640407196 266 17066299
SGTC_460 trequinsin 123 µM 1.88544390104331 0.0239179692942649 no 129 0.0296849658255784 193 5537 A vasodilator.
SGTC_3268 9137683 49.47 µM 1.88347020878723 0.0240328496984126 no 130 0.029818336728967 175 1953228
SGTC_670 4204-0025 119 µM 1.88265191184352 0.0240806151281529 no 131 0.0298737781697109 276 719039
SGTC_266 formosanin C 406 nM 1.88222495705956 0.0241055688760128 no 132 0.0299027392355774 307 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1022 4477-0945 21.3 µM 1.87040822907999 0.0248048769569879 no 133 0.0307135750496145 278 4648966
SGTC_253 dyclonine 31.25 µM 1.86585304349354 0.0250789569894672 no 134 0.031030964361861 290 3180 An oral anasthetic.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.85816295030311 0.0255474195676753 no 135 0.0315729387989878 353 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2278 7948257 134.34 µM 1.85258231744433 0.02589194814521 no 136 0.0319711244257268 252 1247028
SGTC_1820 st053765 18.6 µM 1.85231304434421 0.0259086699583646 no 137 0.0319904418282658 249 3690829
SGTC_1872 amphotericin b 148 nM 1.8512590935699 0.0259742070388098 no 138 0.0320661439948689 257 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2434 5670830 169.91 µM 1.8341821057569 0.0270555654863184 no 139 0.0333134833741568 301 1549830
SGTC_1259 0671-0132 43 µM 1.82654636637498 0.0275510972312938 no 140 0.0338840018830528 293 X1259
SGTC_325 2810-4341 181 µM 1.82480444948365 0.0276651949715427 no 141 0.0340152720918901 242 774970
SGTC_1388 3346-4487 254 µM 1.82322205742807 0.0277691847343587 no 142 0.0341348828126019 297 3345614
SGTC_1358 1509-0022 2.48 µM 1.81785273126484 0.0281244701807237 no 143 0.0345433222889836 269 3258434
SGTC_373 0844-0104 25.9 µM 1.81106494484912 0.028579022921114 no 144 0.0350653995521873 312 5375804
SGTC_2289 7946404 165.07 µM 1.80981813083022 0.0286631781787688 no 145 0.035161997657288 390 1246120 YPR165W RHO1
SGTC_899 1083-0020 478 µM 1.79362341102342 0.0297751067046004 no 146 0.0364366486316129 316 767123
SGTC_602 3130-1533 38.1 µM 1.78954099030946 0.0300609845777036 no 147 0.0367638661076384 331 720941
SGTC_3209 9113616 49.47 µM 1.78554531362907 0.0303429881647415 no 148 0.0370864540836201 312 16649353
SGTC_2246 7293507 91.5585 µM 1.78525011220197 0.0303639093229577 no 149 0.0371103784368838 307 887656
SGTC_3174 9107204 49.47 µM 1.78233110376812 0.0305714258965765 no 150 0.0373476266806512 295 3938802
SGTC_2318 6029776 164 µM 1.77810107632338 0.0308742280244712 no 151 0.0376936278589428 314 818325
SGTC_2658 polymyxin b sulfate 77.05 µM 1.77752116175012 0.0309159334519509 no 152 0.0377412661139359 303 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_264 promethazine 12.5 mM 1.77466042002983 0.0311223508764396 no 153 0.0379769871760228 415 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1058 3448-5425 97.3 µM 1.77419912192118 0.0311557424491897 no 154 0.0380151097069513 287 7279705
SGTC_737 1950-0117 57.9 µM 1.76532331258 0.0318040198735311 no 155 0.0387547218263016 291 5393513
SGTC_2845 9003024 42.97 µM 1.7549787727843 0.0325735922248696 no 156 0.0396314693623612 339 2990173
SGTC_406 estrone 100 µM 1.75491642137102 0.0325782769572268 no 157 0.0396368024335036 285 5870 A steroid.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.75464682849571 0.0325985390365533 no 158 0.0396598680985301 280 4213774
SGTC_577 r071-0003 38.6 µM 1.74959535589675 0.032980123766699 no 159 0.0400940808350188 433 4568517 YMR134W ERG29
SGTC_1958 st076513 41.9 µM 1.74912862810851 0.0330155650635121 no 160 0.0401343938346775 332 732122 YGL099W LSG1
SGTC_1455 4262-0120 131 µM 1.74152757108882 0.0335971873879617 no 161 0.0407955723705982 316 1529587
SGTC_668 1682-0499 62.6 µM 1.74119971610167 0.0336224629201419 no 162 0.0408242885068801 357 682214
SGTC_128 0906-2981 13.371 µM 1.72931348751546 0.0345494366403874 no 163 0.041876502003082 264 6740226
SGTC_2191 5911152 200 µM 1.72897599460071 0.0345760602462468 no 164 0.041906695761413 310 2875902
SGTC_2329 6138490 200 µM 1.72889820162748 0.0345821994442959 no 165 0.0419136579984174 294 720019
SGTC_1096 rimcazole 32.2 µM 1.72791295387571 0.0346600298763432 no 166 0.0420019157704915 272 18528119 A dopamine reuptake inhibitor.
SGTC_164 4100-3994 89.624 µM 1.72757061761377 0.0346871066564027 no 167 0.0420326171968115 383 4615967
SGTC_1557 sumaresinolic acid 42.3 µM 1.7264411916069 0.0347765608149748 no 168 0.0421340353092658 292 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_324 1315-0088 19.6 µM 1.72322606581405 0.0350322466398355 no 169 0.0424238258987375 244 6787421
SGTC_2342 7990637 118.86 µM 1.70962586130818 0.0361309350293428 no 170 0.043667540130559 355 2033102 YER133W GLC7
SGTC_3322 9139058 2.11 µM 1.69920964584506 0.0369913528437475 no 171 0.0446398447886095 320 4908926 YPR165W RHO1
SGTC_1607 st000305 50.6 µM 1.69718645861292 0.0371604029447155 no 172 0.0448307072097641 326 5457690
SGTC_2666 tannic acid 100 µM 1.69555158892963 0.0372974673832727 no 173 0.0449854162385775 362 16134267 A thiamine antagonist.
SGTC_2347 9049783 174.81 µM 1.69315231257404 0.0374993658217267 no 174 0.0452132394868371 376 6467988 YPL169C MEX67
SGTC_1974 st069448 26.9 µM 1.68653969708904 0.0380604387940867 no 175 0.0458459478714568 292 6323587 YNR016C ACC1
SGTC_1731 st035964 63 µM 1.6844103587513 0.0382425616228721 no 176 0.0460511951215859 354 6739575
SGTC_746 1095-0025 46.6 µM 1.68175083501201 0.0384710287410743 no 177 0.0463085829994471 336 6749286
SGTC_2493 resveratrol 26.09 µM 1.68168802750085 0.038476437654739 no 178 0.0463146754233435 254 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_658 3253-0951 102 µM 1.6812862347185 0.038511054273815 no 179 0.0463536651612919 447 1184878
SGTC_1923 st058458 19.1 µM 1.68102230164915 0.0385338073436238 no 180 0.0463792914103806 380 3534982
SGTC_39 0986-0283 58.349 µM 1.66867985019523 0.0396101168592306 no 181 0.0475904222714147 406 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2309 7664088 163.95 µM 1.66611773745821 0.0398365793496385 no 182 0.0478449831637279 395 704922
SGTC_552 k242-0005 476 µM 1.66490644684242 0.0399440098945473 no 183 0.0479657109131153 295 4088318
SGTC_1101 ebselen 5.29 µM 1.66447087698478 0.0399826985199444 no 184 0.0480091831499895 343 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1941 st076221 61.8 µM 1.65713995316416 0.0406384346002489 no 185 0.0487455915899654 422 2828568
SGTC_1103 duloxetine 36.1 µM 1.6520597875619 0.0410979447520947 no 186 0.0492611817100036 399 60835 A selective serotonin reuptake inhibitor.
SGTC_1319 1306-0155 43.7 µM 1.64879815638685 0.0413951797488652 no 187 0.0495944963953664 391 3122360
SGTC_2935 9038016 29.96 µM 1.64772808166975 0.0414930751976592 no 188 0.0497042414123969 370 6463195
SGTC_1767 st044992 70.3 µM 1.64757800606932 0.0415068198041105 no 189 0.0497196483879051 374 9600693
SGTC_3182 9108849 49.47 µM 1.64601037886646 0.0416506108721923 no 190 0.0498808111026605 391 17133045
SGTC_286 k060-0067 22.9 µM 1.64479867528184 0.0417620310059731 no 191 0.0500056677317768 342 5985051
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.63781999069094 0.0424084510478729 no 192 0.0507296250694766 334 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1004 4084-0029 199 µM 1.6368694023573 0.0424971248931159 no 193 0.0508288802181415 375 716894 YLR208W SEC13
SGTC_152 4469-0003 551.229 µM 1.63588566655817 0.04258904865844 no 194 0.0509317591811673 330 697280
SGTC_637 1181-0519 7.26 µM 1.63436510372719 0.0427314517016723 no 195 0.051091105500773 478 6252091 YGR060W ERG25
SGTC_1523 st012844 44.7 µM 1.62374629135409 0.0437366806333489 no 196 0.0522149834779178 377 4274103
SGTC_1934 st074720 32.6 µM 1.62142695745065 0.0439587593059113 no 197 0.0524630516184835 430 17250992
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.62082378544811 0.0440166624226943 no 198 0.0525277179156993 362 390807
SGTC_1136 pergolide 1.05886 µM 1.62020269106972 0.0440763503024611 no 199 0.0525943717759857 478 47811 A dopamine receptor agonist.
SGTC_3211 9128781 49.47 µM 1.61603328344158 0.0444787265123603 no 200 0.0530435586392697 406 17194361
SGTC_1122 capsaicin 818.572 nM 1.6132631429512 0.0447476965055468 no 201 0.0533436751807721 365 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2107 5363541 170.161 µM 1.6127433613123 0.0447983109470315 no 202 0.0534001378973814 362 244052
SGTC_2046 4110841 106 µM 1.60489436059252 0.045568236267053 no 203 0.0542585274204112 357 44119630 YMR134W ERG29
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.60233428798189 0.0458216479723347 no 204 0.0545408536785735 211 6708630 An antioxidant.
SGTC_2738 aclarubicin 5.55 µM 1.59998742041112 0.0460549491629751 no 205 0.0548006870520983 258 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_865 0488-0499 301 µM 1.59189697257911 0.046866540464925 no 206 0.055703927959543 392 9634651
SGTC_471 1-acyl-paf 4 µM 1.59188537540624 0.0468677120128178 no 207 0.0557052310830274 373 16759367
SGTC_2330 7979373 200 µM 1.59141435297976 0.0469153146130949 no 208 0.0557581781428653 400 1863007
SGTC_2424 5537928 59.2 µM 1.59062381446851 0.0469952953827002 no 209 0.0558471308650633 423 5382802
SGTC_641 4092-0595 30 µM 1.59051448199321 0.0470063654255085 no 210 0.0558594419470555 376 786260
SGTC_2616 abietic acid 100 µM 1.58844863563913 0.0472159281009526 no 211 0.0560924635587793 393 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1734 st037168 69.4 µM 1.5867702614096 0.047386735782131 no 212 0.0562823432463114 384 708907
SGTC_2439 5492030 7.2 µM 1.58029308886006 0.0480505631857016 no 213 0.0570198809261641 351 5722370
SGTC_2405 ticlatone 3.52 µM 1.57311970850788 0.0487944062461386 no 214 0.0578455511089144 400 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2139 5578692 56.4705 µM 1.57261149076514 0.0488474530165706 no 215 0.0579044026705126 323 650991 YMR113W FOL3
SGTC_2175 5807670 165.306 µM 1.57059686175048 0.0490581896243552 no 216 0.0581381596946654 345 241186
SGTC_482 fipronil 114 µM 1.56966959106767 0.0491554288419236 no 217 0.0582459996104906 265 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_176 1486-1328 72.834 µM 1.56615178816045 0.0495257274304945 no 218 0.058656543217834 435 22310231
SGTC_91 0417-1751 58.384 µM 1.55865805898123 0.0503219707871206 no 219 0.0595386667510074 494 6795624
SGTC_2617 dihydrotanshinone i 20.83 µM 1.55257037518578 0.050976297583021 no 220 0.0602629038491596 435 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_19 0279-0214 38.434 µM 1.55090185480285 0.0511568138339493 no 221 0.0604626029343028 493 3566274 YBR002C RER2
SGTC_2505 galangin 7.89 µM 1.5491913337272 0.0513424017708028 no 222 0.0606678660692753 317 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2032 5185112 25.99 µM 1.54402874727425 0.0519057805327533 no 223 0.061290684284849 362 5718189
SGTC_2896 9052656 71.43 µM 1.53953472340758 0.0524001903464839 no 224 0.0618369037956749 552 6469436
SGTC_1755 st041960 45.185 µM 1.53672973789352 0.0527106709602891 no 225 0.0621797528202569 392 2257073
SGTC_2324 6149169 200 µM 1.53667692682034 0.0527165305268695 no 226 0.0621862220288983 355 2888231
SGTC_3009 9080819 71.4286 µM 1.5325672397261 0.0531741013817887 no 227 0.0626912592455824 381 17027216
SGTC_683 panaxydol 45 µM 1.53215911280852 0.0532197134113795 no 228 0.062741587730768 424 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1371 2421-0008 32.7 µM 1.52936851654928 0.0535324204468372 no 229 0.063086556379427 422 2827552
SGTC_1411 3909-8223 150 µM 1.52313477964022 0.054236214738823 no 230 0.0638624945419537 410 X1411
SGTC_1822 st052468 42 µM 1.52154446783252 0.0544169294410135 no 231 0.0640616305446839 372 2873678
SGTC_1719 st032227 49.2 µM 1.51593804506928 0.0550578157729747 no 232 0.0647675095325141 416 3125804
SGTC_2146 5545642 200 µM 1.51448391553417 0.0552250117333894 no 233 0.0649515751234328 391 825326
SGTC_359 0081-0058 15.9 µM 1.50634796439747 0.0561678949737536 no 234 0.0659889356147823 406 3494159
SGTC_2647 atorvastatin 60.16 µM 1.50628406443695 0.0561753503281531 no 235 0.065997133582161 400 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_561 1550-0330 72.9 µM 1.50041284635775 0.056863694508907 no 236 0.0667537469557637 389 6812934
SGTC_2767 sibutramine 71.45 µM 1.4952712530242 0.0574719372678627 no 237 0.06742183216966 414 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_863 0466-0191 129 µM 1.49191981495675 0.0578711548348715 no 238 0.0678600837105599 486 765160 YPR165W RHO1
SGTC_350 k064-0020 19.8 µM 1.49064418901521 0.0580236767481457 no 239 0.0680274680859501 464 2790705
SGTC_1203 3992-3522 103 µM 1.49050592861384 0.0580402269950296 no 240 0.0680456293928837 461 5322312
SGTC_1345 1488-0192 31.4 µM 1.48017676010852 0.0592871890600301 no 241 0.0694130403794909 433 658348
SGTC_2612 dictamnine 15.46 µM 1.47997444410838 0.0593118212538771 no 242 0.0694400334559873 438 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1397 3532-0190 20.1 µM 1.47566036973581 0.0598389766400291 no 243 0.0700175449281529 346 5322280
SGTC_2544 sphondin 68.51 µM 1.47396220557938 0.0600474865834007 no 244 0.0702458837255301 397 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2557 derrustone 83.84 µM 1.47292006568737 0.060175727688315 no 245 0.0703862953939259 493 629853 An antioxidant.
SGTC_3332 9141069 11.198 µM 1.47228448239147 0.060254044941176 no 246 0.0704720359469534 380 17332883
SGTC_3245 9134821 49.47 µM 1.4675533747351 0.0608395269229161 no 247 0.0711127904236631 456 17014901
SGTC_1445 4239-0156 97.7 µM 1.46343819062313 0.0613523965722072 no 248 0.0716737574829031 507 4008346
SGTC_1796 st049173 110.4 µM 1.45583668244377 0.0623086368891732 no 249 0.0727188862896777 368 94134
SGTC_1456 k015-0012 13 µM 1.45460605164699 0.0624645328538661 no 250 0.0728891773484677 504 2989616
SGTC_2451 5856223 45.7 µM 1.4536008998627 0.0625920907004229 no 251 0.0730284936492009 431 2179896
SGTC_2698 st077697 67.5 µM 1.45124863277208 0.0628913965175228 no 252 0.0733553195884159 414 3154499
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.44918567208903 0.0631548073126 no 253 0.073642868859303 431 6710655
SGTC_2659 sanguinarine 24.21 µM 1.43891511526465 0.0644790171759588 no 254 0.0750872871998476 458 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1061 3448-9325 110 µM 1.43747042229128 0.0646670032575816 no 255 0.0752921856399853 412 723482
SGTC_1793 st048256 72.231 µM 1.43047990376055 0.0655826410361066 no 256 0.0762896647914037 421 672022
SGTC_441 propafenone 146 µM 1.42618768533293 0.0661498094220223 no 257 0.0769070866681896 405 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1383 3049-0032 20.7 µM 1.42409495798548 0.0664277140935298 no 258 0.0772094928863421 477 712864
SGTC_3059 1327-0034 3 µM 1.42304261981311 0.0665678009511991 no 259 0.0773619002963352 481 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_635 k038-0028 24.7 µM 1.4211407244697 0.0668215605049598 no 260 0.0776379264100044 478 4035102
SGTC_3197 9113331 49.47 µM 1.41760831526102 0.0672948558171886 no 261 0.0781525755531279 494 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1626 st003712 1.76 µM 1.41352848965097 0.0678447179879739 no 262 0.0787501953352161 444 24207035
SGTC_2460 5552655 174.22 µM 1.411711367251 0.0680907364188455 no 263 0.0790174824728838 469 5401989
SGTC_2787 5284540 71.43 µM 1.40893445801749 0.0684680291135054 no 264 0.0794272746832719 470 736958
SGTC_992 3909-8734 162 µM 1.4082871840348 0.0685562041897595 no 265 0.0795230245209293 466 4288319
SGTC_968 1309-0633 340 µM 1.40603055590589 0.0688642990827946 no 266 0.079857525776082 464 3761976
SGTC_2292 7671323 168.05 µM 1.40477999045644 0.0690354964500688 no 267 0.0800433554694036 492 937504
SGTC_3043 9092303 49.47 µM 1.4043987304654 0.0690877545960348 no 268 0.0801000743627104 431 25236084
SGTC_2768 sulfasalazine 50.2 µM 1.39819549136681 0.0699423028779388 no 269 0.0810271851639961 473 5384001 An antioxidant and salicylic acid derivative.
SGTC_2891 9063876 19.48 µM 1.39687145310657 0.0701257491358697 no 270 0.0812261152162936 392 6472478
SGTC_1132 3456-3614 2.5 µM 1.38827804116805 0.0713253800685798 no 271 0.0825261980747252 595 3125502
SGTC_2646 retinol 96.75 µM 1.38692054054778 0.0715163179765789 no 272 0.0827329968355744 457 445354 A vitamin A analog and teratogen.
SGTC_3157 9099274 49.47 µM 1.37725395651407 0.0728873207829172 no 273 0.0842168725965479 464 17217662
SGTC_1133 3473-0247 50 µM 1.37462136959306 0.0732641620527512 no 274 0.0846244299878497 524 711311
SGTC_911 3456-4043 236 µM 1.37354764874288 0.0734182869038808 no 275 0.0847910794730329 521 914281
SGTC_2667 digitoxin 100 µM 1.37104432332805 0.0737785840437744 no 276 0.0851805697311185 382 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1695 st026914 34.495 µM 1.3684521913798 0.0741530854770488 no 277 0.0855852885412401 503 3289191
SGTC_402 epigallocatechin gallate 10 µM 1.36587698185771 0.0745265781318093 no 278 0.0859887893052216 532 65064 An antioxidant.
SGTC_1338 1486-1223 76 µM 1.36506036893197 0.0746453140657801 no 279 0.086117038389842 541 3444526
SGTC_185 k048-0037 25.491 µM 1.36400276774949 0.0747993043107407 no 280 0.0862833472883681 516 6827589
SGTC_785 1270-0111 65.3 µM 1.36362191900548 0.0748548164696085 no 281 0.0863432949405021 500 6741994
SGTC_558 k064-0027 21.3 µM 1.35546373912724 0.0760515065197315 no 282 0.0876349269692687 520 5088526
SGTC_2461 5755302 26.15 µM 1.35332326441744 0.0763678832046943 no 283 0.0879761900432102 549 2788904
SGTC_1229 0139-0193 12.2 µM 1.35302257117911 0.076412407810668 no 284 0.0880242098515971 540 3090752
SGTC_2663 amphotericin b 100 µM 1.3524478566971 0.0764975625607288 no 285 0.088116044399272 476 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1059 3448-6867 171 µM 1.35079842689923 0.0767423574837914 no 286 0.0883800060768515 500 3934407
SGTC_3242 9133940 49.47 µM 1.35076100259317 0.0767479185969076 no 287 0.0883860019950409 495 17248444
SGTC_2346 9031566 143.75 µM 1.35006965145392 0.0768507059366606 no 288 0.0884968210306592 486 4771086
SGTC_2765 myclobutanil 7.74 µM 1.35005245099488 0.0768532645661951 no 289 0.0884995794701493 528 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3269 9137823 49.47 µM 1.34884958349137 0.0770323560617549 no 290 0.08869264237426 465 17682936
SGTC_3084 9116877 49.47 µM 1.3484581194398 0.0770907083791581 no 291 0.0887555408264159 421 27241325
SGTC_3339 9145883 14.936 µM 1.3454030301773 0.0775472599080311 no 292 0.0892475586223536 483 2030670
SGTC_1088 bifonazole 369 nM 1.34430048171299 0.0777125275913671 no 293 0.0894256199360465 499 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1000 4048-0884 8.67 µM 1.34222878290541 0.0780237901003069 no 294 0.0897609133141499 525 13040088
SGTC_2570 licareol 100 µM 1.34210446547871 0.0780424982186098 no 295 0.0897810631074685 513 443158
SGTC_51 1013-0126 23.419 µM 1.33738301624308 0.0787555352051419 no 296 0.0905488226837722 489 1627850
SGTC_2867 9039098 71.43 µM 1.33336893071754 0.079365618771601 no 297 0.0912053815347769 534 6463460
SGTC_1081 sertraline 6 µM 1.33190156297101 0.0795895283130305 no 298 0.0914462686956912 576 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2526 patulin 37.61 µM 1.33059020217863 0.0797900364912409 no 299 0.0916619440681793 598 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_315 k915-0449 187 µM 1.33035818145754 0.0798255524021217 no 300 0.0917001429927908 611 20970215 YNL149C PGA2
SGTC_1933 st074711 15.9 µM 1.33016708480047 0.079854812956585 no 301 0.091731613206106 569 17250958
SGTC_551 k048-0028 34.9 µM 1.32857781546953 0.0800984748286471 no 302 0.0919936475663835 570 6836383
SGTC_2866 9034245 58.44 µM 1.32798256496047 0.0801898813383149 no 303 0.0920919333787497 460 6462273
SGTC_312 4092-0653 6.84 µM 1.32736033493629 0.0802855150764122 no 304 0.0921947570485768 620 1148278
SGTC_2483 5729050 27.16 µM 1.3272428768127 0.0803035774874029 no 305 0.0922141765650838 635 2865180
SGTC_1635 st007035 42.4 µM 1.32669326065892 0.0803881368648011 no 306 0.0923050856082491 723 3716403
SGTC_1693 xanthone 101.9 µM 1.31986605914501 0.0814441286180183 no 307 0.0934398706602396 563 7020 An insecticide.
SGTC_2602 kawain 100 µM 1.31843171795575 0.0816673080968061 no 308 0.0936795844229943 588 5369129
SGTC_2747 doxorubicin 7.63 µM 1.31786541307571 0.0817555503973095 no 309 0.0937743528444506 345 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2252 omeprazole 400 µM 1.3174003423979 0.0818280719962766 no 310 0.0938522331156289 412 4594 A proton pump inhibitor.
SGTC_113 0099-0221 2.5 µM 1.31718857193633 0.0818611108499547 no 311 0.0938877118003009 496 89219
SGTC_412 gemfibrozil 100 µM 1.31538066841642 0.082143575907285 no 312 0.0941909995860092 457 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1851 st056236 18.9 µM 1.31481456181255 0.0822321746135051 no 313 0.0942861161391171 539 5393171
SGTC_844 0330-0132 15.3 µM 1.31179040034874 0.0827066916043115 no 314 0.0947954324042129 538 2828079
SGTC_1798 st045719 60.953 µM 1.31151419522764 0.0827501330517516 no 315 0.0948420505274419 492 3980186
SGTC_2985 9022375 71.43 µM 1.29959247662989 0.0846415825578606 no 316 0.0968703397921653 542 4939335
SGTC_53 0973-0023 39.979 µM 1.2970972038283 0.0850415439260954 no 317 0.0972988717535005 520 674768
SGTC_2965 9082772 38.63 µM 1.29593259156291 0.0852287010025035 no 318 0.0974993547738239 586 16459634
SGTC_2862 9027634 71.43 µM 1.29481520451224 0.0854085587603558 no 319 0.0976919928128057 525 5012562
SGTC_1498 4478-3555 97.6 µM 1.29169770873007 0.0859118625660321 no 320 0.0982309256368534 482 3437919
SGTC_2248 tofa 1.1 µM 1.28529817082314 0.086951984787454 no 321 0.0993440545702721 516 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_659 k018-0002 107 µM 1.28177697642016 0.0875282846689386 no 322 0.0999604464809736 573 6797879 YHR007C ERG11
SGTC_763 3453-1109 128 µM 1.27918484951467 0.087954345887622 no 323 0.100415984863776 572 1560353
SGTC_1256 0570-0116 285 µM 1.27902786221344 0.0879801990677878 no 324 0.100443622261645 529 410638
SGTC_937 3122-0005 46.7 µM 1.27712225478933 0.0882944727097714 no 325 0.100779544510041 586 759535
SGTC_607 4491-0986 66.8 µM 1.27138443166489 0.0892458088527361 no 326 0.101795959197492 591 698981 YDR232W HEM1
SGTC_2983 9022671 12.99 µM 1.27089485855367 0.0893273322842555 no 327 0.10188302788198 527 6405161
SGTC_2491 paeonol 100 µM 1.26847809991849 0.0897305814313514 no 328 0.102313633336616 508 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1343 1487-0095 224 µM 1.26794493154846 0.0898197253654495 no 329 0.102408808452056 542 4560101 YGL055W OLE1
SGTC_2441 5730946 39.09 µM 1.26388987611399 0.0904998720492269 no 330 0.103134778008062 582 1774275
SGTC_2797 7859098 81.82 µM 1.25804774550001 0.091486473522009 no 331 0.104187244759977 583 972681
SGTC_1077 5-fluorocytosine 377 nM 1.253207198461 0.0923099511315139 no 332 0.105065155454186 556 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3026 9090633 49.47 µM 1.25285549779213 0.0923699958026641 no 333 0.105129150017488 580 25236842
SGTC_2919 7978188 46.38 µM 1.24712661190405 0.0933521426800579 no 334 0.106175538290124 596 2980291
SGTC_3093 9117344 49.47 µM 1.24327885739944 0.0940161100424448 no 335 0.106882546227581 552 24824913
SGTC_2126 5251174 33.877 µM 1.24023953650281 0.0945430327715421 no 336 0.107443404423833 679 790722
SGTC_2178 5812956 200 µM 1.2361408540113 0.0952570588200673 no 337 0.108203105638707 557 5403383
SGTC_3142 9086498 49.47 µM 1.23395124183667 0.095640131635191 no 338 0.108610536771621 566 25236367
SGTC_671 0560-0003 407 µM 1.23096839493946 0.096163803143424 no 339 0.109167342565871 553 3238678
SGTC_285 1486-1325 46 µM 1.23042031810071 0.0962602528512078 no 340 0.109269874332354 629 22310230
SGTC_1275 0867-0008 21.1 µM 1.23018540227912 0.0963016147336638 no 341 0.109313842510488 596 3422836
SGTC_713 1488-1073 324 µM 1.21700144347364 0.0986439133842336 no 342 0.111801833327156 599 3312542
SGTC_31 0508-1974 57.237 µM 1.21464856870835 0.0990662801131638 no 343 0.112250078130082 592 6810525
SGTC_2086 5274770 176.623 µM 1.2057709807144 0.100671814947287 no 344 0.113952903818545 591 689278
SGTC_3133 9127736 49.47 µM 1.2031870110474 0.101142679194231 no 345 0.114451980069946 637 27243420
SGTC_277 nystatin 15.5 µM 1.20306397760535 0.101165138943737 no 346 0.114475781893427 639 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3068 9116768 49.47 µM 1.20065044846227 0.101606463802313 no 347 0.114943411491043 567 41904888
SGTC_2200 6600604 21.907 µM 1.19900384406895 0.101908356396002 no 348 0.115263225443766 660 2904777
SGTC_259 usnic acid 108.925 µM 1.19723212931089 0.102233915576737 no 349 0.115608045020828 639 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.18899449321172 0.10375754964465 no 350 0.117220916953647 663 165521
SGTC_2196 6573537 42.6665 µM 1.18559616266133 0.104390881585132 no 351 0.117890909201186 612 2903087
SGTC_1689 st020265 53.493 µM 1.18391496893245 0.104705231984108 no 352 0.118223362040029 646 5758320 YPR016C TIF6
SGTC_2970 9090938 41.86 µM 1.18004412456285 0.105431609424762 no 353 0.118991332935426 708 17217104
SGTC_2263 7948595 193.29 µM 1.17864784143637 0.105694519285437 no 354 0.119269216474066 572 2971371
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.17730917285562 0.105947025496015 no 355 0.119536063515746 671 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3176 9106582 49.47 µM 1.17708280584161 0.105989767003733 no 356 0.119581228581516 468 17018027
SGTC_2223 6903751 107.57 µM 1.17690562523592 0.106023230067332 no 357 0.119616588302927 592 5598863
SGTC_1989 st071868 50.2 µM 1.17490485823176 0.106401633134325 no 358 0.120016390872811 649 16414057
SGTC_250 brefeldin a 552.239 µM 1.17451531533142 0.106475420272035 no 359 0.120094340559533 544 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1252 0493-0875 34.8 µM 1.1735695303617 0.106654724392472 no 360 0.120283745812292 623 3960963
SGTC_1482 3346-2049 8.48 µM 1.17113347907934 0.107117560004511 no 361 0.120772564292551 619 3826804
SGTC_2445 5742597 35.57 µM 1.17049306857127 0.10723947437802 no 362 0.120901300962735 614 1774255
SGTC_3060 1327-0027 12.5 µM 1.16794545263798 0.107725452317212 no 363 0.121414384154443 615 16000455 YPR107C YTH1
SGTC_2784 7567673 72.73 µM 1.16581291897162 0.108133468265386 no 364 0.121845046380538 687 3471247
SGTC_54 0159-0055 9 µM 1.16465792325276 0.108354916542843 no 365 0.122078743662194 638 3319099
SGTC_2369 9071472 200 µM 1.16315808433037 0.108642968679402 no 366 0.122382684653689 656 17296037
SGTC_161 4065-0411 162.148 µM 1.16189215035153 0.108886526399268 no 367 0.122639638020921 698 1906281 YLR208W SEC13
SGTC_1373 2887-0003 58.5 µM 1.15533334714777 0.110154684973015 no 368 0.123976972552681 638 776948
SGTC_1742 st038235 28.8875 µM 1.153402291442 0.110530069614538 no 369 0.124372650698427 666 564103 YBR002C RER2
SGTC_448 monastrol 171 µM 1.15011896970494 0.111170429409243 no 370 0.125047437136003 655 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_876 0720-0963 56.8 µM 1.14686312082144 0.111808049926764 no 371 0.12571909835938 707 765861
SGTC_939 1165-0479 45.3 µM 1.14522320690848 0.112130196863599 no 372 0.126058353707299 674 1377347
SGTC_2600 tangeritin 87.95 µM 1.143270512521 0.112514651516678 no 373 0.126463146985646 624 68077 A bioactive flavone.
SGTC_3075 9116269 49.47 µM 1.13913182399045 0.113332604464901 no 374 0.12732408788993 665 17015205 YNL244C SUI1
SGTC_2861 9024595 19.48 µM 1.13312794737846 0.114526710889714 no 375 0.128580263289411 558 16482810
SGTC_25 0118-0223 35.662 µM 1.12852293814921 0.115448646727926 no 376 0.129549567567402 675 5333628
SGTC_3298 9116858 71.43 µM 1.1261167269409 0.115932469343957 no 377 0.130058057392881 713 2506942
SGTC_2887 9044784 58.44 µM 1.12414297071386 0.116330410594488 no 378 0.130476189171248 728 6465546
SGTC_399 oxolinic acid 75 µM 1.12360472531938 0.116439097570248 no 379 0.130590375301284 668 4628 A DNA gyrase inhibitor.
SGTC_1739 st037196 92.5 µM 1.1233384084093 0.116492901119692 no 380 0.130646898676754 738 612214
SGTC_2015 5119600 184 µM 1.12284717338672 0.116592190746906 no 381 0.130751203273697 699 2828786
SGTC_2129 girgensonine 121.053 µM 1.12064646930342 0.117037739090151 no 382 0.131219188243376 738 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_584 0986-0246 15.4 µM 1.12062811101889 0.117041460923907 no 383 0.131223097035648 748 53315 YDR232W HEM1
SGTC_923 1900-2434 73.3 µM 1.11891817665452 0.117388489154179 no 384 0.13158752387501 672 5910570
SGTC_2671 danthron 100 µM 1.11681168564162 0.11781699877064 no 385 0.132037425670116 685 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2010 4012422 159 µM 1.11659487469399 0.117861165939619 no 386 0.132083792026766 700 952393
SGTC_2771 fluoxetine 41.05 µM 1.11475729923127 0.118235974073239 no 387 0.132477219694834 654 3386 A selective serotonin reuptake inhibitor.
SGTC_827 3253-0474 693 µM 1.11437873639109 0.118313293677286 no 388 0.132558370776121 741 5402065
SGTC_1962 st076595 64.5 µM 1.11413251017994 0.118363603356433 no 389 0.132611171734482 694 279619
SGTC_1307 1187-1599 12.2 µM 1.11357023851379 0.118478545085196 no 390 0.132731800062941 697 1538471
SGTC_377 3970-0964 33.1 µM 1.11186738921785 0.118827129232271 no 391 0.13309758593006 784 16481235
SGTC_2533 agelasine 13.65 µM 1.11161830755059 0.118878178511651 no 392 0.133151148805761 727 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_3261 9137475 49.47 µM 1.10882783877432 0.119451143950183 no 393 0.133752229256498 458 17027690
SGTC_2770 toltrazuril 17.5 µM 1.10344400586959 0.120562103242821 no 394 0.134917197646703 739 68591 Kills coccidiodes.
SGTC_2940 9060638 45.86 µM 1.09538988497027 0.122237629014648 no 395 0.13667293180699 700 4027022
SGTC_3023 9089636 49.47 µM 1.09419360217846 0.122487883334874 no 396 0.136935038422994 754 17249241
SGTC_3189 9110682 49.47 µM 1.09372524148976 0.122585959105916 no 397 0.137037750177144 702 17122418
SGTC_513 4245-1575 41.7 µM 1.09370768218006 0.122589637135647 no 398 0.13704160196683 824 719745
SGTC_313 3474-0040 5.03 µM 1.09166418480795 0.123018203590765 no 399 0.1374903664631 737 1043375 YIL048W NEO1
SGTC_838 0109-0203 71.4 µM 1.09083155715434 0.123193124778519 no 400 0.137673503931103 737 759422
SGTC_1233 0325-0408 14.2 µM 1.09069786792274 0.123221226889562 no 401 0.137702924544872 713 12874
SGTC_1075 aripiprazole 15.2 µM 1.0876653608868 0.123859881199072 no 402 0.138371432438606 768 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1965 Pectolinarigenin 58.4 µM 1.08679740759974 0.124043100274281 no 403 0.138563176856324 728 5320438 An anti-inflammatory.
SGTC_3270 9137563 49.47 µM 1.08678764005602 0.124045163215306 no 404 0.138565335688672 660 17015724
SGTC_300 r073-0011 5.04 µM 1.08629080352224 0.124150128580705 no 405 0.138675177230074 797 2735780
SGTC_1491 4138-0063 26.5 µM 1.08455087246585 0.124518209079913 no 406 0.13906031189808 693 23883227
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.08358990838524 0.124721826710792 no 407 0.139273333632282 632 61125 An anti-inflammatory.
SGTC_1098 clofazimine 15.1 µM 1.08350043836042 0.12474079625125 no 408 0.139293178194905 758 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1825 st052143 62.6 µM 1.08024351225765 0.125432706573097 no 409 0.140016878362121 699 674173
SGTC_1457 k015-0032 57.3 µM 1.0801067473104 0.125461819783386 no 410 0.140047323796672 729 4302660
SGTC_182 3448-4371 550.524 µM 1.07951951993235 0.12558687671214 no 411 0.140178098414693 779 3491403
SGTC_360 0957-0399 1.01 µM 1.07915628384352 0.125664275607379 no 412 0.140259032035279 758 6752301 YPR165W RHO1
SGTC_1901 st060216 58.6 µM 1.07866761870382 0.125768453607431 no 413 0.140367962902808 729 688792
SGTC_3125 9127534 49.47 µM 1.07718703821599 0.12608446471166 no 414 0.140698357381402 611 1639235
SGTC_44 0929-0055 61.211 µM 1.07652176872811 0.126226638130415 no 415 0.140846985296722 664 1379590
SGTC_1150 3909-7983 10.9 µM 1.07596681682908 0.126345321245672 no 416 0.140971048609416 738 23965914
SGTC_3307 9126885 69.2785 µM 1.07588300522528 0.126363252118022 no 417 0.140989791710225 744 24824909
SGTC_290 2043-6722 48.1 µM 1.07523701852911 0.126501515694397 no 418 0.141134312837928 733 773758 YLR208W SEC13
SGTC_820 1582-0060 59.9 µM 1.07518249852483 0.126513189688578 no 419 0.14114651473137 737 3848840
SGTC_2829 7992743 58.44 µM 1.07277603136876 0.127029217737294 no 420 0.141685808697364 734 16462845
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.07254710099694 0.127078384356747 no 421 0.141737185047549 661 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2312 7706453 155.7 µM 1.06992854492223 0.127641705119402 no 422 0.142325736645897 709 976098
SGTC_2007 4011539 71.82 µM 1.06938994343658 0.127757787485999 no 423 0.142446998459632 722 45595301
SGTC_694 1315-0438 43.2 µM 1.06717787623277 0.128235313842699 no 424 0.142945760437273 644 6793154
SGTC_1115 galangin 695.678 nM 1.06654425342505 0.12837232419289 no 425 0.143088842601485 792 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1301 naphtanilide LB 4.81 µM 1.0648456143081 0.128740127841206 no 426 0.143472899735144 804 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2011 4012611 177 µM 1.06451655728825 0.128811462488643 no 427 0.143547378914049 745 2049887
SGTC_730 1436-0052 41.2 µM 1.0639692444479 0.128930172460131 no 428 0.14367131618418 706 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1413 3910-0535 34.4 µM 1.06338995874984 0.129055899846871 no 429 0.14380257224928 769 2876951
SGTC_834 0312-0008 75.7 µM 1.06318251690124 0.129100943411442 no 430 0.143849594631602 767 6385573 YIL048W NEO1
SGTC_954 1189-0853 2.85 µM 1.05945424922872 0.129912351758322 no 431 0.14469647729976 771 2828194
SGTC_1052 3253-3998 198 µM 1.05886532563874 0.130040845411441 no 432 0.144830558848529 774 5450317
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.05665790338019 0.130523252079483 no 433 0.145333871922155 668 1241132 A phosphatase inhibitor.
SGTC_2004 4023728 41.89 µM 1.05441721612395 0.131014192644484 no 434 0.145845971774056 755 360084 YDR527W RBA50
SGTC_2843 9000894 45.46 µM 1.05359544311394 0.131194564658943 no 435 0.146034088191302 604 2242070
SGTC_2908 7930301 100 µM 1.0529784636127 0.131330098958704 no 436 0.146175431333367 829 2223178
SGTC_1360 1598-0022 39.8 µM 1.05271148545541 0.131388777054366 no 437 0.14623662153325 832 761525
SGTC_697 0508-1955 564 µM 1.05167449473369 0.131616864918406 no 438 0.146474458324728 796 6243113
SGTC_2745 rifampicin 24.3 µM 1.04932096544607 0.132135541126251 no 439 0.147015209941815 618 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2927 9011802 47.9 µM 1.04830988468153 0.132358797637299 no 440 0.147247928466507 712 43912568
SGTC_327 1273-0057 3.96 µM 1.04030246957332 0.13413609563576 no 441 0.149099698606208 725 3108138
SGTC_976 1348-1067 47.6 µM 1.04017237518918 0.134165105634681 no 442 0.149129911680016 820 5310671 YGL099W LSG1
SGTC_898 1000-0849 28.3 µM 1.0395477995529 0.134304440978487 no 443 0.149275019841358 783 6751807
SGTC_175 3793-3120 23.7 µM 1.03948058078376 0.134319442601691 no 444 0.149290642449459 713 5322297
SGTC_1086 cerivastatin 2.18 µM 1.03942760088822 0.134331267259389 no 445 0.149302956507937 732 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1068 loratadine 26.9 µM 1.03800175829423 0.134649771601385 no 446 0.149634618247459 724 3957 A H1 histamine antagonist.
SGTC_2349 9023730 187.07 µM 1.03658826839462 0.134966027794148 no 447 0.149963891523487 754 4126287
SGTC_1737 st035557 69.7 µM 1.03504702101954 0.13531144884652 no 448 0.150323476214289 639 5716916
SGTC_2656 pseudo-anisatin 100 µM 1.0336174464016 0.135632383313258 no 449 0.150657520005879 768 6708809 A neurotoxin.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.03341790979599 0.135677220016331 no 450 0.150704184322646 818 6708739 YPR165W RHO1
SGTC_2387 9077560 195.08 µM 1.03203483408837 0.135988281946913 no 451 0.15102789969982 759 5303272
SGTC_2917 7979103 53.79 µM 1.03026573785653 0.136386873341046 no 452 0.151442638991748 828 2980565
SGTC_1400 3771-8998 51.5 µM 1.03001930208905 0.136442460628266 no 453 0.151500472367408 728 670767
SGTC_516 3992-2719 87.3 µM 1.02889607128056 0.136696018478092 no 454 0.151764257364847 720 5350887 YDR037W KRS1
SGTC_789 1309-1135 70.6 µM 1.02822953854063 0.136846633632467 no 455 0.15192093336922 758 3092424
SGTC_75 0159-0059 199.013 µM 1.02777759053445 0.136948823985558 no 456 0.152027229931557 744 5377270
SGTC_1288 0973-0013 65.5 µM 1.02764330965624 0.136979196397209 no 457 0.15205882183269 797 4315430
SGTC_1506 4226-2149 212 µM 1.02697341941097 0.137130784735269 no 458 0.152216490236226 834 991114
SGTC_427 1354-0053 47.3 µM 1.02689916113037 0.137147595570217 no 459 0.152233974682289 751 6813657
SGTC_89 0302-0250 142.109 µM 1.02674095617207 0.137183415226 no 460 0.152271229197352 825 4203518 YLR208W SEC13
SGTC_1377 2944-0135 198 µM 1.02502656587523 0.137571985287492 no 461 0.152675326425199 796 1894137
SGTC_1206 3978-0017 132 µM 1.02195930909337 0.138269058252193 no 462 0.153400079835745 726 3873677
SGTC_1617 st002906 78 µM 1.02176169730131 0.138314050450553 no 463 0.153446850982143 805 5150859
SGTC_740 k014-0057 261 µM 1.01859271858269 0.139036925976564 no 464 0.154198181275813 856 4012779
SGTC_2125 5246583 200 µM 1.0176324149804 0.139256487618026 no 465 0.154426338359603 878 835267
SGTC_72 0744-0168 198.391 µM 1.01674656974233 0.139459234362385 no 466 0.154637002791373 757 677577
SGTC_1703 st026983 48.3 µM 1.01663235719965 0.139485389223358 no 467 0.154664177694175 827 1104023
SGTC_3179 9107801 49.47 µM 1.01538849862188 0.139770450921825 no 468 0.154960336689783 775 4818259
SGTC_3149 9097855 49.47 µM 1.01514968316768 0.139825226818096 no 469 0.155017240761566 776 25236625 YMR079W SEC14
SGTC_2966 9084041 48.03 µM 1.01491430803015 0.139879227902398 no 470 0.155073338587709 718 17741380
SGTC_2813 7971799 71.43 µM 1.01425716675816 0.140030067962594 no 471 0.155230028438567 763 2234054
SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.01390898084076 0.140110035258553 no 472 0.155313092805228 838 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2027 5150920 200 µM 1.01325140596448 0.140261144027383 no 473 0.155470046009805 781 786715
SGTC_3086 9117350 49.47 µM 1.0131519898967 0.140283999175382 no 474 0.155493784229028 742 2679265
SGTC_1315 1237-0019 3.69 µM 1.0128324828039 0.14035746903443 no 475 0.155570091200606 830 825140
SGTC_806 3966-4455 5.86 µM 1.01221583267405 0.140499340060729 no 476 0.155717433831166 693 714982
SGTC_1005 4092-0690 4.4 µM 1.00716080248826 0.14166600688318 no 477 0.156928753089875 736 1529343
SGTC_65 0798-0905 34.986 µM 1.00436036236556 0.142315146488198 no 478 0.157602474149066 880 3602145
SGTC_1938 st074717 56.4 µM 1.00371507858757 0.142465007543092 no 479 0.157757983486989 731 17250979
SGTC_2839 9003951 25.97 µM 1.00169819055407 0.142934098709794 no 480 0.158244690436327 779 2990634
SGTC_2610 ononetin 44.17 µM 1.00144160104884 0.142993851480311 no 481 0.158306680114538 788 259632
SGTC_1507 4075-3230 155 µM 1.00128525829688 0.14303026776187 no 482 0.158344458904487 729 659771
SGTC_2986 9022445 71.43 µM 1.00125994228706 0.14303616510654 no 483 0.15835057684212 797 6459286
SGTC_1405 3909-7894 12 µM 1.00052401853756 0.143207669772585 no 484 0.158528490008289 803 7104060
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.999529294817756 0.143439707610511 no 485 0.158769177611363 752 6708760
SGTC_483 fpl-64176 144 µM 0.998091759612108 0.143775487726706 no 486 0.15911743279425 748 3423
SGTC_702 1488-0190 94 µM 0.99530793255837 0.144427242191649 no 487 0.159793260432883 803 949357
SGTC_2380 9035439 200 µM 0.990622257137153 0.145528750358644 no 488 0.160935032712229 862 6462575
SGTC_3040 9091894 49.47 µM 0.984130750592977 0.147064085447533 no 489 0.162525614541228 745 25236966
SGTC_3004 9076122 71.4286 µM 0.983482181272699 0.147218076059194 no 490 0.16268509043528 821 44782551
SGTC_2692 st077426 47.7 µM 0.982109675780863 0.147544308000678 no 491 0.163022909594452 844 25238571
SGTC_2711 st079103 59.1 µM 0.981476016402198 0.147695086296664 no 492 0.163179027952078 804 54693780
SGTC_1424 4048-1941 275 µM 0.981013150826428 0.147805289661791 no 493 0.163293128228426 913 X1424
SGTC_1079 idarubicin 2.36 µM 0.980714861887347 0.147876338248782 no 494 0.163366686431996 801 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3195 9113082 49.47 µM 0.980236286297491 0.147990376558891 no 495 0.163484748379042 796 17018038
SGTC_1911 st060208 74.3 µM 0.977920538274076 0.148543020441061 no 496 0.164056813151445 840 688783
SGTC_1336 1486-0901 104 µM 0.977726669912361 0.148589348855408 no 497 0.164104763753026 827 5006114
SGTC_2669 eugenol 100 µM 0.977512830919948 0.14864046082285 no 498 0.164157664350777 773 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_154 3389-1638 511.116 µM 0.97671868544533 0.148830380977954 no 499 0.164354220969349 731 5238686
SGTC_2262 9014885 67.46 µM 0.972404159188813 0.149865034241067 no 500 0.165424761803757 767 6457424
SGTC_3325 9138760 55.175 µM 0.972396426675775 0.149866892847338 no 501 0.165426684472543 797 43844959
SGTC_326 k292-0812 17.5 µM 0.972325074036561 0.149884044072491 no 502 0.165444426798559 823 3579357
SGTC_2536 dehydroabietamide 32.04 µM 0.971295429392875 0.150131688255684 no 503 0.165700592087802 874 3983547
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.970094961832082 0.150420761977437 no 504 0.165999580039071 782 17037758
SGTC_3108 9121785 49.47 µM 0.969857851193475 0.150477902269668 no 505 0.166058675919319 822 17140271
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.969073233909101 0.150667086957373 no 506 0.166254325618129 904 1377
SGTC_609 0986-0026 86.3 µM 0.968338782352721 0.150844319289284 no 507 0.166437600999725 834 2848610
SGTC_2143 5623677 140.463 µM 0.964243275564057 0.151835160120404 no 508 0.167461986285727 816 5375313
SGTC_1846 st056244 14.8 µM 0.96212085426982 0.152350342629134 no 509 0.167994449835445 858 5393182
SGTC_767 0929-0023 86 µM 0.961760861206763 0.15243783992135 no 510 0.168084871249589 914 1204563
SGTC_2475 5812728 15.03 µM 0.96092242275261 0.152641753929753 no 511 0.16829558777883 900 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.959838785186518 0.152905570007839 no 512 0.168568179401678 848 6312947
SGTC_1249 0481-0015 10.2 µM 0.959823654482958 0.152909255779523 no 513 0.168571987574535 791 4227577
SGTC_2194 5927483 104.545 µM 0.959592264067502 0.152965628788274 no 514 0.168630231987738 896 760979
SGTC_1472 k841-0093 193 µM 0.957214128003026 0.153545805972424 no 515 0.169229593773175 884 X1472
SGTC_2518 prenyletin 46.28 µM 0.954129571308617 0.154300491786453 no 516 0.170009029568965 760 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2817 7995342 71.43 µM 0.949509650649042 0.155435409399526 no 517 0.171180733017569 761 18879975
SGTC_2834 9001755 58.44 µM 0.945567305267838 0.156408220168473 no 518 0.172184663358828 779 2989575
SGTC_3294 9122953 26.2835 µM 0.945206143361207 0.156497540320968 no 519 0.172276821846737 875 16459826
SGTC_2948 9070189 9.45 µM 0.944717475639985 0.156618447816018 no 520 0.172401566366863 779 6473636 YDL196W YDL196W
SGTC_2307 7538926 6.34 µM 0.943687625279888 0.156873457490283 no 521 0.172664649748681 853 96582
SGTC_3148 9097893 49.47 µM 0.943360301366367 0.156954566026019 no 522 0.172748320793154 817 17174100
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.940886722316698 0.157568393146584 no 523 0.173381456300672 856 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_554 4483-2211 187 µM 0.940386439628152 0.157692731526684 no 524 0.173509687668399 838 747107
SGTC_1210 3013-0140 750 nM 0.938822352802946 0.15808187943626 no 525 0.173910980204806 930 905973
SGTC_1493 4348-0038 111 µM 0.938201736531603 0.15823646453676 no 526 0.174070373070211 926 800424
SGTC_3235 9132602 49.47 µM 0.936084793590685 0.158764505528725 no 527 0.1746147658524 888 4912240
SGTC_2269 7935389 174.42 µM 0.936068356873837 0.158768609945537 no 528 0.1746189969416 824 97605
SGTC_463 ikarugamyin 104 µM 0.935071844635844 0.159017579216279 no 529 0.17487563767323 871 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2118 5526350 200 µM 0.934806331254259 0.159083958389039 no 530 0.17494405808229 888 743594
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.933977079385599 0.159291390805735 no 531 0.175157858181994 914 5393153
SGTC_2298 7976326 193.81 µM 0.933466175428661 0.159419278527959 no 532 0.175289663378434 804 2235818
SGTC_1170 0310-0127 64.8 µM 0.932960922171259 0.159545817878102 no 533 0.175420072618315 896 774975
SGTC_1811 st050069 61.5 µM 0.931517649376139 0.159907643772038 no 534 0.175792929630416 881 3877702
SGTC_1368 1852-0141 284 µM 0.928844745250676 0.160579152292538 no 535 0.1764847758774 841 2838987
SGTC_1483 3453-0561 55.9 µM 0.927137004970744 0.161009147546543 no 536 0.17692770254464 905 4546991
SGTC_1863 st057641 20.1 µM 0.927097247941141 0.161019166989352 no 537 0.176938022454799 950 3921635
SGTC_2195 6536160 144.242 µM 0.926313714366019 0.161216713713745 no 538 0.177141485390145 794 3834386
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.924979681798664 0.16155341742579 no 539 0.177488238209801 850 4330530
SGTC_797 k781-0471 270 µM 0.924949670317816 0.161560997455279 no 540 0.177496043967627 907 23738129
SGTC_1354 1498-1681 81 µM 0.924843259370884 0.161587875642193 no 541 0.177523722391488 935 5754243
SGTC_972 1319-0219 195 µM 0.921178405070584 0.16251535476237 no 542 0.17847864542583 860 23903702
SGTC_1985 st071382 65.5 µM 0.919148489601467 0.163030561227748 no 543 0.179008954760129 903 6123237
SGTC_3328 9140624 29.0385 µM 0.917944551185545 0.163336630089468 no 544 0.179323947968318 913 4904392
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.916093647097703 0.163807900112658 no 545 0.179808889788242 923 4174840
SGTC_1907 st060210 83.7 µM 0.915790539128129 0.163885160300797 no 546 0.17988838331425 953 688793
SGTC_1835 st008666 49.2 µM 0.915774161828252 0.163889335437923 no 547 0.17989267907658 787 690455
SGTC_103 0844-0104 51.839 µM 0.914696967477004 0.164164100904506 no 548 0.180175368402552 984 5375804
SGTC_3342 9147791 14.508 µM 0.914573176303783 0.164195696080528 no 549 0.180207872913182 898 1838168
SGTC_2886 9058944 51.95 µM 0.914184577883696 0.164294903532274 no 550 0.180309933188333 749 4949929
SGTC_1171 0368-0077 21.4 µM 0.912900105426245 0.164623100140177 no 551 0.180647541041605 847 3239779
SGTC_3186 9110464 49.47 µM 0.912397540767928 0.164751626392131 no 552 0.1807797418223 872 17018021
SGTC_2788 5282734 71.43 µM 0.908187748240098 0.165830793791855 no 553 0.181889518003698 942 743706
SGTC_1212 0520-0165 585 µM 0.907960198258487 0.165889255410764 no 554 0.18194962535847 869 5403258
SGTC_2898 9056270 58.44 µM 0.907142892267542 0.166099345623447 no 555 0.182165619246881 851 19154699
SGTC_1736 st036774 51 µM 0.906531267246119 0.166256677515654 no 556 0.182327361510672 941 1272247
SGTC_2391 6285546 200 µM 0.905078272455854 0.166630825684265 no 557 0.182711960955067 915 846083
SGTC_50 0929-0078 56.389 µM 0.903239935359843 0.167104978086759 no 558 0.183199283536324 856 1377751
SGTC_3206 9114350 49.47 µM 0.901710107106759 0.167500220986477 no 559 0.183605441282665 830 17087243
SGTC_2513 baicalein 25.65 µM 0.900376697235709 0.167845208522395 no 560 0.18395990876008 889 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2992 9074591 71.4286 µM 0.899797397140298 0.167995230842609 no 561 0.184114039894254 877 17741321
SGTC_1183 1254-0324 198 µM 0.899328646955927 0.168116687016497 no 562 0.184238816454573 921 5799357
SGTC_3081 9117243 49.47 µM 0.897911055863204 0.168484337655199 no 563 0.184616484993008 916 45595589
SGTC_2130 NSC 7 2.4545 µM 0.896017155531453 0.16897632459442 no 564 0.18512180039026 951 21448
SGTC_1603 st002045 67.8 µM 0.895490877016957 0.169113201990814 no 565 0.185262370224131 940 5887985
SGTC_2910 7948405 25.97 µM 0.891557439694762 0.170138485750387 no 566 0.18631509550404 893 2971328
SGTC_859 0439-0102 54.6 µM 0.88721427444874 0.171275185805731 no 567 0.187481774330909 993 610143
SGTC_1012 4112-3522 18 µM 0.887199444223806 0.17127907549481 no 568 0.187485765805701 961 3112398
SGTC_3136 9095672 49.47 µM 0.884072760704623 0.172100406762295 no 569 0.18832846820439 821 17217380
SGTC_1398 3558-0053 112 µM 0.883131180040461 0.172348237085423 no 570 0.188582699701611 872 4532369
SGTC_2603 homopterocarpin 100 µM 0.882610174563276 0.172485467002009 no 571 0.188723464683189 916 101795 A weak amylase inhibitor.
SGTC_2096 5468907 200 µM 0.880865104353793 0.172945616126237 no 572 0.189195418377088 949 759785
SGTC_2515 chrysin 20.77 µM 0.880447116595518 0.173055949301462 no 573 0.189308570826393 949 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_86 0417-1630 471.922 µM 0.879454022215215 0.173318268946268 no 574 0.189577576012971 1034 3634867
SGTC_723 4182-0001 115 µM 0.875541786297102 0.174354122909396 no 575 0.190639592121437 896 744821 YLR208W SEC13
SGTC_1866 st057638 64 µM 0.87520505076746 0.17444346481483 no 576 0.190731172770857 926 688802
SGTC_271 rotenone 740 µM 0.874733424835321 0.174568644412385 no 577 0.190859484416429 964 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3117 9124945 49.47 µM 0.874332837236724 0.174675013710472 no 578 0.190968510792174 839 17592065
SGTC_524 r073-0010 27.8 µM 0.872026656250887 0.175288181404795 no 579 0.191596917864987 901 2772106
SGTC_3076 9116187 49.47 µM 0.871682193514967 0.175379884217412 no 580 0.19169088849742 912 27241210
SGTC_3058 9093861 49.47 µM 0.87107098725736 0.175542674294582 no 581 0.19185769714923 929 17217477
SGTC_1283 0922-0125 16.4 µM 0.869342329572913 0.17600360718804 no 582 0.19232995829323 994 3360884
SGTC_2311 7694451 200 µM 0.867063363245723 0.176612445448903 no 583 0.192953646500798 918 2163142
SGTC_975 1335-0046 28.5 µM 0.864514678334708 0.177294916077765 no 584 0.193652610242146 959 16486740
SGTC_2841 9004761 38.96 µM 0.864421352846821 0.177319937748605 no 585 0.193678233546003 912 2991039
SGTC_1661 st013063 9.66 µM 0.864292236510976 0.177354559046839 no 586 0.193713686938929 1025 721395
SGTC_196 k015-0023 18.111 µM 0.862419024687514 0.177857322754145 no 587 0.194228487593034 969 5211998
SGTC_2564 betulinic acid 100 µM 0.861433825192173 0.178122107327396 no 588 0.194499576552141 1011 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1339 1486-1321 22.7 µM 0.859950760584548 0.178521167639881 no 589 0.194908092820529 952 3469382
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.858883674723292 0.17880864522525 no 590 0.195202348543482 966 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3127 9126946 49.47 µM 0.858751924577626 0.178844159489097 no 591 0.195238698199946 846 27243249
SGTC_2456 5770359 74.46 µM 0.85732396246893 0.179229362441451 no 592 0.195632934507999 990 3118787
SGTC_1804 st050076 49.1 µM 0.856295375295944 0.179507154213207 no 593 0.195917209347133 953 3895976
SGTC_531 3788-1495 174 µM 0.854336590840777 0.18003691342732 no 594 0.196459259262698 902 2896655
SGTC_901 1112-0062 60.1 µM 0.853848763216079 0.180169000415294 no 595 0.19659439590463 952 1908457
SGTC_2982 9019404 25.97 µM 0.85345746452073 0.1802749946332 no 596 0.196702833065284 898 22333232
SGTC_99 0109-0120 622.8 µM 0.852721784880851 0.180474380004233 no 597 0.19690680354148 941 759414
SGTC_2816 7982706 58.44 µM 0.851609460123444 0.18077610706909 no 598 0.197215443621613 928 2981853
SGTC_1407 3909-7909 12.3 µM 0.851367758428942 0.180841712403713 no 599 0.197282548003033 996 4411780
SGTC_2296 7971656 126.45 µM 0.850717986638208 0.181018154590595 no 600 0.197463014597162 949 666570
SGTC_1610 st001799 48.1 µM 0.847675326993574 0.181845807561747 no 601 0.198309405381748 895 621897
SGTC_782 0083-0095 30.5 µM 0.844681782400635 0.182662406461329 no 602 0.199144266791214 1029 3591729 An indicator and reagent.
SGTC_2060 5238662 140 µM 0.84384682046592 0.182890580667231 no 603 0.199377504114429 918 790130
SGTC_2370 9071495 200 µM 0.842865560317804 0.183158961775037 no 604 0.199651818333523 914 21791103
SGTC_3162 9099653 49.47 µM 0.842523119742669 0.183252679319554 no 605 0.199747602053163 961 25237511
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.840757764090213 0.183736287968022 no 606 0.20024182640325 982 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1080 nisoldipine 24.4 µM 0.837829232061407 0.184540293457064 no 607 0.201063309314698 995 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2385 9074692 200 µM 0.837294223003967 0.184687412028268 no 608 0.201213602854839 961 17046906
SGTC_1148 3909-7663 27.7 µM 0.837217720503909 0.184708454897757 no 609 0.20123509926832 1021 4084526
SGTC_841 0251-0215 91.2 µM 0.833273701605091 0.185795320068833 no 610 0.202345192273676 1034 3888614
SGTC_881 0833-0569 170 µM 0.833229544390398 0.185807511017006 no 611 0.202357641564508 945 5418700
SGTC_2740 felodipine 17.08 µM 0.833013339092305 0.185867208256296 no 612 0.202418603167588 944 3333 L-type calcium channel blocker
SGTC_2506 ethyl hematommate 54.16 µM 0.829661974023515 0.186794086616401 no 613 0.203364963310807 918 3940691 An allergen.
SGTC_3119 9125183 49.47 µM 0.82833972471321 0.187160563334182 no 614 0.203739065812374 866 22695334
SGTC_1786 berberine 21.6 µM 0.827651794351137 0.187351406938832 no 615 0.203933863318049 941 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3012 9080433 71.4286 µM 0.827327324014051 0.18744146227612 no 616 0.204025780327703 1041 17688859
SGTC_2243 6634756 200 µM 0.827315838160633 0.187444650615241 no 617 0.204029034529781 959 885676
SGTC_2361 9034121 116 µM 0.826651249473654 0.187629189771436 no 618 0.204217380192025 975 6496917
SGTC_754 3474-0146 171 µM 0.8255834045549 0.187925937769095 no 619 0.204520226164481 921 24762078
SGTC_2426 5582046 32.21 µM 0.824274172988188 0.188290160926754 no 620 0.204891895042298 1004 2251934
SGTC_595 3909-8003 73.7 µM 0.8237807459558 0.188427543340532 no 621 0.205032074834279 1015 699517
SGTC_3222 9128301 49.47 µM 0.823306971733267 0.188559512083984 no 622 0.205166725007339 1013 4911358
SGTC_1702 st027038 51 µM 0.823294090101439 0.188563101029176 no 623 0.205170386796948 1018 5521182
SGTC_2137 5261020 140 µM 0.822147639998976 0.188882681600406 no 624 0.205496437277577 982 763655
SGTC_3301 9125354 19.7965 µM 0.821085177671935 0.189179147784432 no 625 0.205798876135099 939 41905162
SGTC_1521 st012942 49.4 µM 0.819454315103305 0.189634775711444 no 626 0.206263628418216 1041 24207259
SGTC_2436 5633522 8.09 µM 0.818597632941219 0.189874384484302 no 627 0.206508008972929 1033 5724242
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.816503557296597 0.190460867813594 no 628 0.207106094899565 1061 3256 An antibiotic and ribosome inhibitor.
SGTC_3250 9135583 49.47 µM 0.814214147747113 0.191103329219651 no 629 0.207761140982672 1010 7699353
SGTC_504 lovastatin 124 µM 0.814114476878302 0.191131329329811 no 630 0.207789686592381 1004 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2661 dactinomycin 12.96 µM 0.813360279656292 0.191343284247891 no 631 0.208005762787325 1048 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2220 6782180 200 µM 0.812694782601095 0.191530431008145 no 632 0.20819653665547 968 833803
SGTC_1430 4049-0248 69.1 µM 0.811421199679895 0.191888892233458 no 633 0.208561914408581 1095 22774488
SGTC_303 1348-1668 34.2 µM 0.809360474287341 0.192469770853358 no 634 0.209153915266358 1003 5380509
SGTC_2336 9001819 198.65 µM 0.808255142936796 0.192781784859916 no 635 0.209471859768919 1044 2989602
SGTC_1273 0849-0096 14.1 µM 0.807406856345272 0.193021449481141 no 636 0.209716059029754 999 5286025
SGTC_1329 1447-1697 50.6 µM 0.805048440944762 0.193688723065062 no 637 0.210395863427898 1005 2840515
SGTC_2128 5255449 168.493 µM 0.804643827557404 0.193803342740508 no 638 0.210512621592511 1081 736008
SGTC_3069 9117009 49.47 µM 0.804426324691008 0.193864974463617 no 639 0.210575401504595 922 41904981
SGTC_2173 5763948 167 µM 0.803125142980626 0.194233927416879 no 640 0.210951203300259 1082 2867177
SGTC_2543 pimpinellin 60.67 µM 0.802996557732734 0.194270411251504 no 641 0.210988362084404 971 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1683 st010134 710 nM 0.80151530008394 0.194690993292923 no 642 0.211416695077826 1054 3818134
SGTC_652 0437-0092 114 µM 0.801054075303784 0.19482206452434 no 643 0.211550170639832 1026 3091274
SGTC_2344 7990960 76.95 µM 0.800915477455577 0.194861461857666 no 644 0.21159028962717 972 140813
SGTC_3214 9129694 49.47 µM 0.800780911816614 0.19489971764498 no 645 0.2116292456992 1003 17158655
SGTC_902 1120-0002 2.07 µM 0.798114745916021 0.195658625743021 no 646 0.212401952496294 1067 3280475
SGTC_3316 9136639 10.545 µM 0.79810212491195 0.195662222496955 no 647 0.212405614224946 1030 4903665
SGTC_3219 9131112 49.47 µM 0.79565031182321 0.196361705220944 no 648 0.213117657427804 1005 17612988 YMR079W SEC14
SGTC_606 k015-0008 38.6 µM 0.795543023849751 0.196392348199082 no 649 0.213148847224043 1116 1970475
SGTC_1640 st009078 66.4 µM 0.795382992557404 0.196438060808218 no 650 0.213195375031374 990 690618
SGTC_16 erodoxin 22.806 µM 0.795244963019012 0.196477493840709 no 651 0.213235510763518 1090 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1362 1611-0397 101 µM 0.794356919419056 0.196731309678593 no 652 0.213493838229331 1069 27816
SGTC_1267 0828-0272 9.49 µM 0.793124824579135 0.19708378910355 no 653 0.213852550387495 1064 745334
SGTC_3290 9121031 71.43 µM 0.791546427649338 0.197535897115739 no 654 0.21431259734487 1011 17014854
SGTC_2883 9059145 45.46 µM 0.787595732582012 0.198670259751446 no 655 0.215466605813386 1063 16476510
SGTC_1725 st036284 20.55 µM 0.786966264067628 0.198851361100512 no 656 0.215650807560883 1104 707914
SGTC_1855 st056195 39.6 µM 0.786634249360951 0.198946923523273 no 657 0.215748001991166 1015 4028379
SGTC_605 1315-0399 119 µM 0.786339242327223 0.199031857397466 no 658 0.215834384046723 1078 24020461
SGTC_1510 1123-0200 71.5 µM 0.786198697179363 0.199072328670974 no 659 0.215875544618166 1104 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2065 5221596 34.26 µM 0.784082761404579 0.199682230968807 no 660 0.216495774913515 1021 788581
SGTC_650 1328-0195 38 µM 0.783979303381147 0.199712080753332 no 661 0.216526127298481 1075 2780821
SGTC_469 w7 172 µM 0.783614296933911 0.199817414121542 no 662 0.216633232095846 1095 45115570 A P450 inhibitor.
SGTC_2996 9066192 71.4286 µM 0.782674057833606 0.200088901687964 no 663 0.216909270018227 1078 6472854
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.78255799729697 0.200122428736195 no 664 0.216943357474515 1034 688662
SGTC_786 4544-0069 423 µM 0.781598015188933 0.200399873524042 no 665 0.217225426861775 1067 748821 YLR208W SEC13
SGTC_2276 7947513 42.08 µM 0.780528856287034 0.200709143348361 no 666 0.217539824625673 1013 2105100
SGTC_563 tetrahydrosecaminediol 614 µM 0.780087441431226 0.200836912557248 no 667 0.217669704010324 1110 334274 A psychoactive constituent of the cannabis plant.
SGTC_2858 9025781 8.96 µM 0.77941499698726 0.201031647948549 no 668 0.21786764619161 1134 4894980 YPL153C RAD53
SGTC_1795 st049545 62.3 µM 0.779254442897781 0.201078160077972 no 669 0.217914922583448 1061 5291882
SGTC_1035 k081-0041 55.2 µM 0.77812170778259 0.201406494053386 no 670 0.21824863324323 1093 731709
SGTC_622 1348-1566 26.3 µM 0.777958510493486 0.201453824797041 no 671 0.218296736413848 1118 7340407
SGTC_2390 9097792 176.6 µM 0.777794530415413 0.201501389279382 no 672 0.21834507646682 1015 4497149
SGTC_632 0781-2353 4.65 µM 0.777540568804626 0.201575067315876 no 673 0.218419954545549 1099 6811515 YHR007C ERG11
SGTC_2024 5144227 134 µM 0.777184096718162 0.201678512387063 no 674 0.218525081772767 1087 3475211
SGTC_2591 skatole 100 µM 0.776024514591039 0.202015232824997 no 675 0.218867255747148 1067 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_348 k064-0012 10.7 µM 0.775652385284265 0.202123363322962 no 676 0.218977130401155 1033 5066323
SGTC_2035 5154463 94.595 µM 0.775467796281902 0.202177012635968 no 677 0.219031643797928 1076 2769623
SGTC_726 3448-4391 34.2 µM 0.774629719546455 0.202420700048638 no 678 0.219279245355773 1126 1356692
SGTC_3299 9121982 43.1275 µM 0.774072871349731 0.202582711766201 no 679 0.219443849614768 1103 17594604 YPL160W CDC60
SGTC_2754 granisetron 64.02 µM 0.774017035026811 0.202598961291456 no 680 0.219460358740092 1054 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1093 fluphenazine 7.97 µM 0.773054641486765 0.202879160142045 no 681 0.219745021749368 1150 6602611 An atypical antipsychotic.
SGTC_1162 k048-0130 20.1 µM 0.772240948716568 0.203116245573817 no 682 0.219985866373061 1037 6797406
SGTC_2786 7743617 45.45 µM 0.771196674736576 0.203420757624436 no 683 0.220295182448881 997 583674
SGTC_644 1498-1197 63.3 µM 0.771069760816851 0.203457784490048 no 684 0.220332791596402 1110 6741615
SGTC_1461 k072-0203 53.8 µM 0.770468832286028 0.203633158688835 no 685 0.220510918246877 1062 5418714
SGTC_3103 9120822 49.47 µM 0.769485792547639 0.203920241991068 no 686 0.22080248776589 1110 17141819
SGTC_328 k915-0120 63.5 µM 0.768482034260729 0.204213624585772 no 687 0.221100430065199 1060 6624543
SGTC_231 b-estradiol 524 µM 0.767844674632986 0.204400045085101 no 688 0.221289734796451 1046 450 A steroid.
SGTC_3204 9114183 49.47 µM 0.767769999390841 0.204421893378545 no 689 0.221311920453919 1059 17027248
SGTC_202 3594-0513 34.79 µM 0.766308548924435 0.204849760610796 no 690 0.221746366385098 1073 708429
SGTC_2707 st078556 66.6 µM 0.766241661675725 0.204869355852391 no 691 0.221766261635798 1057 17250899
SGTC_1877 wortmannin 25 µM 0.763952387697226 0.205540691617123 no 692 0.222447808253935 1117 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2081 5214970 32.255 µM 0.763566452209834 0.205653996755771 no 693 0.22256282381845 1060 2063512
SGTC_1680 diphenhydramine 100 µM 0.7615402129717 0.20624947962069 no 694 0.223167234778795 1040 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1106 tegaserod maleate 11.7 µM 0.759874565516495 0.20673975423107 no 695 0.223664783130323 1089 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1305 1181-0477 144 µM 0.759181372762933 0.206943995058308 no 696 0.223872033627835 1086 6252086
SGTC_2094 5332512 191.667 µM 0.756995756480413 0.207588741650007 no 697 0.224526202390787 1139 755774
SGTC_3151 9099821 49.47 µM 0.755904847944445 0.207910998166353 no 698 0.224853123558009 1088 17174189
SGTC_805 3852-0218 479 µM 0.755450857093456 0.208045194948778 no 699 0.224989254060197 1073 6615355
SGTC_1682 st012968 530 nM 0.753461302698881 0.208633897175721 no 700 0.225586378407007 1054 24207270
SGTC_2205 7238770 200 µM 0.7526120869946 0.20888547587857 no 701 0.225841526094611 1115 279867
SGTC_1992 st073643 23.3 µM 0.752178372071468 0.2090140321019 no 702 0.2259718991023 1130 3161292
SGTC_1944 st076371 56.9 µM 0.750029124097831 0.209651771904999 no 703 0.22661858211662 1092 24208455
SGTC_151 3013-0144 2.285 µM 0.749411906297139 0.209835128345438 no 704 0.226804488456063 1086 906558 YHR107C CDC12
SGTC_10 0279-0212 42.575 µM 0.748038609510019 0.210243430654018 no 705 0.227218434740783 1163 39851 YBR002C RER2
SGTC_788 1182-0090 188 µM 0.74678610521891 0.210616225995276 no 706 0.227596342098797 1175 5715185
SGTC_646 4092-0839 27.3 µM 0.74521445776611 0.211084559365957 no 707 0.228071042035554 1149 877796
SGTC_1192 1488-0095 21.4 µM 0.743274476579886 0.211663492966186 no 708 0.228657760470919 1086 915875
SGTC_3238 9133470 49.47 µM 0.742398234671863 0.211925287463501 no 709 0.228923044412588 1121 3534688
SGTC_2991 9074669 71.4286 µM 0.740515071732625 0.212488559933965 no 710 0.229493759704742 1127 17333109
SGTC_2947 9072639 7.68 µM 0.740349041586099 0.212538263094148 no 711 0.229544115364868 1161 16488146
SGTC_1284 0929-0043 16 µM 0.73980393977507 0.212701493745163 no 712 0.229709484050834 1097 1239883
SGTC_1579 chlormadinone acetate 49.4 µM 0.739446797167478 0.212808479720248 no 713 0.229817867325527 1154 45114258 A steroidal progestin.
SGTC_4 0960-0234 25.671 µM 0.738433837928289 0.213112093583924 no 714 0.230125429209797 1117 6821112
SGTC_3126 9127922 49.47 µM 0.737922700452766 0.213265392480567 no 715 0.230280711776718 1157 45595682
SGTC_1618 st003135 44.5 µM 0.736975191976713 0.213549736539176 no 716 0.230568717933671 1098 1270615
SGTC_1625 st003711 30.1 µM 0.735280315783234 0.214058913735995 no 717 0.23108439686819 1156 24207034 YER133W GLC7
SGTC_304 1310-0298 97 µM 0.734335198511526 0.214343153854412 no 718 0.23137223527826 1099 1550234
SGTC_2193 5925765 200 µM 0.733918566390215 0.214468523926666 no 719 0.231499185360128 1142 877370
SGTC_799 1310-0557 151 µM 0.733801290171399 0.214503821568245 no 720 0.231534927066989 1131 5354492
SGTC_2022 5136654 200 µM 0.731862879926607 0.215087730817632 no 721 0.232126132415547 1117 1713771
SGTC_2122 5258151 111.688 µM 0.731791594794286 0.21510922168692 no 722 0.232147890028059 1127 2173356
SGTC_1752 st044819 83.042 µM 0.729352751763587 0.215845228767451 no 723 0.232892955829934 1116 441209 YML126C ERG13
SGTC_2384 9036245 200 µM 0.726813628454828 0.216613047388185 no 724 0.233670066615296 1153 6462766
SGTC_1649 st011737 51.3 µM 0.726468327740175 0.216717586561285 no 725 0.233775858475734 1107 1761035
SGTC_322 k048-0136 19.3 µM 0.725462477535462 0.217022272142899 no 726 0.234084178104817 1167 6823282
SGTC_508 roscovitine 141 µM 0.723105517035225 0.217737196099035 no 727 0.234807530019975 1173 160355 A CDKinase inhibitor.
SGTC_2285 7945142 200 µM 0.722914014427726 0.217795343159381 no 728 0.234866356455057 1158 2970608
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.7226907516533 0.217863145052692 no 729 0.234934949370895 1114 15053
SGTC_517 1365-0151 113 µM 0.722287410358308 0.217985665219755 no 730 0.235058895783631 1173 768657
SGTC_2282 7944268 200 µM 0.721740226440287 0.21815194294179 no 731 0.23522710263163 1170 2970414
SGTC_2630 antimycin a 100 µM 0.721679083578949 0.218170527514922 no 732 0.235245902355252 1189 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1166 k206-0078 225 µM 0.72070656869542 0.218466249249799 no 733 0.235545035053392 1180 5404595
SGTC_138 0850-0259 40.9225 µM 0.720434543592425 0.218549007773706 no 734 0.235628743915773 1194 6813004
SGTC_255 tunicamycin 200.472 nM 0.71964741183279 0.218788579472743 no 735 0.235871056267639 1150 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_835 0312-0010 67.2 µM 0.719500535583923 0.218833299503642 no 736 0.235916286173508 1129 1626196
SGTC_1261 0712-0010 12.7 µM 0.719338538275868 0.21888262960604 no 737 0.235966178087699 1171 2840123
SGTC_3063 1327-0034 4 µM 0.718675491756844 0.219084601804234 no 738 0.236170443679218 1088 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3091 9116372 49.47 µM 0.718215768265635 0.219224702173657 no 739 0.236312128441176 1173 17169793
SGTC_3053 9095903 49.47 µM 0.718146058354278 0.219245950709594 no 740 0.236333616815558 1207 17174018
SGTC_2989 9073649 71.4286 µM 0.717177476743236 0.219541310124427 no 741 0.236632297478649 1167 21367202
SGTC_653 0203-0016 55.2 µM 0.715937821813207 0.219919663909327 no 742 0.237014871571348 1174 295302
SGTC_3177 9107506 49.47 µM 0.715910622587015 0.219927969549586 no 743 0.23702326942575 1118 8897194
SGTC_1361 1608-0041 5.61 µM 0.714773018845599 0.220275512934488 no 744 0.2373746548965 1166 X1361
SGTC_64 000l-0018 272.079 µM 0.714164351560076 0.220461592941004 no 745 0.237562778741773 1132 6811119
SGTC_1309 pyrazolanthrone 13.4 µM 0.713884105037415 0.220547299378518 no 746 0.237649423439268 1187 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1026 k007-1105 30.6 µM 0.711229236681928 0.221360171441109 no 747 0.238471096982206 1153 7066794
SGTC_1496 4469-0713 57.4 µM 0.710074215482289 0.221714351899136 no 748 0.238829057422686 1164 746691
SGTC_603 3794-0023 45.9 µM 0.709067750808198 0.222023242190231 no 749 0.239141217180948 1164 3802260
SGTC_2933 9026794 32.47 µM 0.708800370589593 0.22210534413446 no 750 0.239224183887316 1162 17586027
SGTC_645 0845-0943 5.41 µM 0.70844161334306 0.222215531588966 no 751 0.239335529119585 1151 1885106
SGTC_2064 5220758 200 µM 0.708167499680565 0.222299742925451 no 752 0.239420623129119 1220 788518
SGTC_211 3455-0679 143.504 µM 0.707953187597278 0.222365595107489 no 753 0.239487164244068 1200 748649
SGTC_1500 4488-1866 171 µM 0.707659059723973 0.222455990589855 no 754 0.239578503560746 1224 2900003
SGTC_3090 9117696 49.47 µM 0.707154233493014 0.222611189674604 no 755 0.239735318072425 1142 7923821
SGTC_1355 1499-0035 1.68 µM 0.706580029076173 0.22278779275533 no 756 0.239913751637787 1187 1548538
SGTC_205 1486-1330 71.903 µM 0.703946681673639 0.223598730504557 no 757 0.240732989288739 1152 4118834
SGTC_1837 st055472 66.5 µM 0.70113456473641 0.224466570741211 no 758 0.241609520640896 1240 676091
SGTC_2531 methyl deoxycholate 70.07 µM 0.700789802791627 0.224573098222853 no 759 0.24171710138101 1170 16667744 Haematoxylin.
SGTC_3293 9120939 62.045 µM 0.700339568289862 0.224712258689436 no 760 0.241857633291687 1185 934087
SGTC_2277 7947813 106.88 µM 0.699272924462444 0.225042136768246 no 761 0.242190742183666 1221 1246798
SGTC_395 anisomycin 6.25 µM 0.698253384795218 0.22535770341402 no 762 0.242509372952924 1157 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_813 k007-0158 173 µM 0.696924151947412 0.225769501933032 no 763 0.242925131066235 1219 6523916
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.695801725361763 0.226117562737549 no 764 0.243276504293307 1193 688667
SGTC_1401 3807-4679 7.6 µM 0.694066968722936 0.226656101150622 no 765 0.243820106067115 1175 3291456
SGTC_298 1391-0729 10 µM 0.693499023475502 0.226832571425663 no 766 0.243998219223029 1169 3237558
SGTC_2199 6590217 200 µM 0.692036223949651 0.227287444911602 no 767 0.244457290411312 1147 703109
SGTC_453 enantio-paf c16 10 µM 0.691888878250151 0.227333292143484 no 768 0.244503557778647 1202 13871343 A lipid and platelet activating factor
SGTC_942 3253-1115 227 µM 0.690970837692166 0.227619061650884 no 769 0.244791933839344 1232 46497897
SGTC_2835 9006588 71.43 µM 0.690922410691355 0.227634141718673 no 770 0.244807150872064 1196 2345538
SGTC_1418 3966-3099 2.4 µM 0.690897417867924 0.227641924652195 no 771 0.244815004471337 1201 740335
SGTC_123 0083-0120 66.675 µM 0.69063310208864 0.227724243535346 no 772 0.244898069822806 1156 16001701
SGTC_1568 digitonin 820 nM 0.688814771144705 0.228291001021827 no 773 0.245469919489137 1217 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_56 0957-0365 83.25 µM 0.688148725401634 0.228498799743283 no 774 0.245679564620297 1183 6752360
SGTC_945 3381-0768 11.3 µM 0.688089675727449 0.228517227698685 no 775 0.245698155785423 1223 1126236 YIL048W NEO1
SGTC_1143 3454-2408 5.08 µM 0.687197486035654 0.2287957598043 no 776 0.245979144180854 1174 X1143
SGTC_2320 7373003 200 µM 0.686976344869419 0.228864827178687 no 777 0.246048817573923 1215 5415828
SGTC_3327 9140648 26.9345 µM 0.6856562510068 0.229277365605497 no 778 0.246464950406793 1198 8029710
SGTC_2473 5854593 8.94 µM 0.685191125562634 0.229422819780389 no 779 0.246611661571417 1160 2872951
SGTC_1029 k015-0030 64.7 µM 0.684310084969041 0.229698480782793 no 780 0.246889690023898 1203 2208316
SGTC_1218 1348-1416 30.7 µM 0.684252286967836 0.22971657117008 no 781 0.246907935100892 1209 6787668
SGTC_1979 st071809 45.3 µM 0.684093586638588 0.229766247413396 no 782 0.246958035694911 1264 4976333
SGTC_1882 5615643 20 µM 0.683948803789628 0.229811572465638 no 783 0.247003747381768 1153 2253075
SGTC_333 3486-0131 40.1 µM 0.683583728630878 0.229925883438213 no 784 0.247119031140592 1280 6744690
SGTC_3240 9133527 49.47 µM 0.681426362051976 0.230602039381985 no 785 0.24780087342406 1199 17617455
SGTC_510 ag-490 170 µM 0.67823517112059 0.231604247982557 no 786 0.248811297866719 1310 5328779
SGTC_1191 1487-1166 10.6 µM 0.67526892334942 0.23253798505076 no 787 0.249752462102619 1285 3955771
SGTC_3129 9127257 49.47 µM 0.675109049831894 0.232588370578387 no 788 0.249803242193682 1139 837894
SGTC_307 1501-1223 22.3 µM 0.67433006277894 0.232833961930476 no 789 0.250050747652808 1217 2830329
SGTC_130 0136-0219 337.655 µM 0.671908126849805 0.233598445567852 no 790 0.250821093175745 1195 234244
SGTC_1553 gossypol 38.6 µM 0.668824903883503 0.23457367489855 no 791 0.251803589264402 1168 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2894 9048625 32.47 µM 0.66872314054606 0.234605901180984 no 792 0.251836051648817 1298 4092861
SGTC_1092 toremifene 6.32 µM 0.668225760634549 0.234763446035112 no 793 0.251994747035726 1253 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2907 7721985 69.9 µM 0.668129741867979 0.234793866668432 no 794 0.252025389120099 1208 3267881
SGTC_2808 7946468 45.46 µM 0.668107065051828 0.234801051447767 no 795 0.252032626168573 1238 2970879
SGTC_3170 9103054 49.47 µM 0.666881809410943 0.235189434344493 no 796 0.252423815555355 1206 16432970
SGTC_1009 4106-0057 9.87 µM 0.664396412229538 0.235978346865634 no 797 0.253218314269743 1265 2928005
SGTC_21 0849-0113 22.993 µM 0.664148996647686 0.236056961030208 no 798 0.253297476697784 1214 1560156
SGTC_452 diindolylmethane 8 µM 0.662217820682024 0.236671071127997 no 799 0.253915817439777 1225 3071 Inhibits expression of several cancer promoting factors.
SGTC_2476 5806916 10.51 µM 0.659395799366217 0.237570046548878 no 800 0.254820819432502 1185 2870194
SGTC_2721 ifenprodil 61.44 µM 0.659325242606193 0.237592546904882 no 801 0.254843468095264 1260 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_861 0443-0273 110 µM 0.65812086608576 0.237976799545653 no 802 0.255230234421702 1264 6149169
SGTC_1114 scopoletin 1.73284 µM 0.657792456648418 0.238081636653834 no 803 0.255335751106972 1270 5280460 A coumarin with genotoxic properties.
SGTC_2198 6589944 200 µM 0.657414712983286 0.238202253866028 no 804 0.255457146879707 1222 5290268
SGTC_1816 st051957 91.6 µM 0.657153294479601 0.238285746925257 no 805 0.255541176799206 1254 674121
SGTC_1280 0880-0253 10.1 µM 0.655735434444905 0.238738868799343 no 806 0.255997182729013 1239 6836607
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.655533977144767 0.238803289058189 no 807 0.2560620089704 1255 688798
SGTC_2811 7967822 32.47 µM 0.655229640185274 0.238900625307123 no 808 0.256159956734186 1279 2232244
SGTC_173 1273-0061 2.693 µM 0.654818089255691 0.239032286357225 no 809 0.256292441294041 1209 2847414 YPL266W DIM1
SGTC_509 pifithrin 175 µM 0.653633804335575 0.239411377315637 no 810 0.256673879960028 1306 4817 A p53 inhibitor.
SGTC_987 1497-1013 404 µM 0.653532259354488 0.239443897256986 no 811 0.256706599679579 1253 1676435
SGTC_1234 0326-0494 15.5 µM 0.652533798605857 0.239763784328216 no 812 0.257028438292004 1311 1547813
SGTC_2849 9019321 12.99 µM 0.650792656678222 0.240322169158955 no 813 0.257590170574198 1246 16489627
SGTC_1175 0741-0056 27.6 µM 0.65000480535186 0.240575065987039 no 814 0.257844558812459 1318 765927
SGTC_3317 9138495 8.753 µM 0.647596396162995 0.241349052471822 no 815 0.25862301439775 1258 17020139
SGTC_1393 3470-5649 58.2 µM 0.646688467153346 0.241641182883908 no 816 0.258916794335423 1221 4108395
SGTC_2585 alliin 100 µM 0.643529135320669 0.242659207223565 no 817 0.259940407924672 1374 87310 A garlic compound which reacts with lipids.
SGTC_530 4358-1714 28 µM 0.642811011402476 0.242890930133686 no 818 0.26017336861417 1309 1564641
SGTC_2089 5281248 129.67 µM 0.641082730363648 0.243449099160356 no 819 0.260734466893112 1298 2737878
SGTC_2598 perillyl alcohol 100 µM 0.637964403045305 0.244457950949669 no 820 0.261748426200211 1308 10819 An apoptosis inducer.
SGTC_1246 0422-0085 105 µM 0.636562700205557 0.244912167329287 no 821 0.262204863842747 1275 264295
SGTC_2255 7941087 197.44 µM 0.636280275878767 0.245003740779401 no 822 0.262296879242764 1316 935561
SGTC_2417 cerulenin 830 nM 0.636116416671705 0.245056879039636 no 823 0.262350273055016 1366 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_528 3492-0019 172 µM 0.635284264469473 0.245326835154428 no 824 0.262621517207664 1340 2869262
SGTC_503 tyrphostin 8 294 µM 0.635000837210801 0.245418817460539 no 825 0.262713934484687 1260 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1001 4048-4355 44.4 µM 0.634404090000699 0.245612543896126 no 826 0.262908570541488 1279 21824233
SGTC_1971 st069429 63.5 µM 0.634279125959863 0.245653122289836 no 827 0.262949338353599 1276 1246522 YGL099W LSG1
SGTC_3193 9111931 49.47 µM 0.634178523994854 0.245685792432283 no 828 0.262982160719022 1343 17087244
SGTC_3300 9124615 50.48 µM 0.634102654259911 0.245710432411195 no 829 0.263006915340032 1342 24824903
SGTC_1525 8-methoxypsoralen 92.5 µM 0.632117929285847 0.246355476505745 no 830 0.263654910144868 1339 4114 Related to psoralen; DNA damaging agent.
SGTC_3071 9117417 49.47 µM 0.631440706439922 0.246575784336816 no 831 0.263876203514945 1243 45595590 YGL055W OLE1
SGTC_580 1123-0028 41 µM 0.630972107908056 0.246728286203369 no 832 0.264029380970589 1341 1677248 YPR107C YTH1
SGTC_2551 apiole 73.87 µM 0.628586711408038 0.247505377820728 no 833 0.264809831151509 1207 10659 A possible DNA adduct former.
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.62858019597822 0.247507502144401 no 834 0.264811964464294 1318 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1306 1185-0270 9.02 µM 0.628522738476883 0.247526236300348 no 835 0.264830777848842 1277 1548076
SGTC_928 2764-0428 58.7 µM 0.628329830155682 0.247589140062011 no 836 0.264893947041528 1339 662578
SGTC_627 1391-0720 175 µM 0.625425430019283 0.248537241372257 no 837 0.265845938084739 1276 997839
SGTC_769 0302-0231 76 µM 0.625322671193864 0.248570820965164 no 838 0.265879651635517 1309 571869 YER009W NTF2
SGTC_73 0327-0325 16.231 µM 0.624872628629525 0.248717914622771 no 839 0.266027329024654 1320 53298
SGTC_3097 9117246 49.47 µM 0.624379179139799 0.248879248827796 no 840 0.26618929774029 1313 16423892
SGTC_2700 st077718 96.8 µM 0.622453690304749 0.249509323295532 no 841 0.26682179285803 1305 904970
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.622203242144027 0.249591339272508 no 842 0.266904117218604 1257 2333 A French combination drug.
SGTC_3128 9127691 49.47 µM 0.621077992735682 0.249960009071634 no 843 0.267274154178468 1326 41316314
SGTC_2184 6075246 200 µM 0.620087355667312 0.250284814357571 no 844 0.267600138163166 1333 2267320
SGTC_2145 5634607 200 µM 0.619790878361264 0.250382065391637 no 845 0.267697737420703 1271 308662
SGTC_407 eburnamonine 100 µM 0.618512040366703 0.250801781628011 no 846 0.26811893173772 1255 3195
SGTC_3353 9151644 39.2805 µM 0.618354744142148 0.250853432160874 no 847 0.268170761385891 1312 4909158
SGTC_2760 etidronate 98.04 µM 0.617677030267859 0.251076033875421 no 848 0.268394128087131 1292 3305 A chelator and antioxidant.
SGTC_1142 3253-1408 9.78 µM 0.617557695723033 0.251115241285313 no 849 0.268433469066701 1303 256655
SGTC_1686 st019653 115.5 µM 0.617108802477791 0.251262754331252 no 850 0.268581481516382 1341 97252
SGTC_7 0192-1582 4.227 µM 0.61596539983994 0.251638700463633 no 851 0.268958678027135 1355 252616
SGTC_1570 verbenone 133 µM 0.613601404481261 0.252416913689265 no 852 0.269739377611982 1347 29025 A natural terpanoid with antifungal properties.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.613007444116404 0.252612641108354 no 853 0.26993570878478 1382 688801
SGTC_2077 5212015 200 µM 0.612217113361352 0.252873202258587 no 854 0.270197060242717 1224 780900
SGTC_393 acivicin 6.25 µM 0.611974275778478 0.252953290862677 no 855 0.270277388682888 1286 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2101 5377231 179.231 µM 0.611764743214749 0.253022406092328 no 856 0.270346709723751 1374 2844213
SGTC_22 0964-0034 14.468 µM 0.611627086910753 0.253067818031834 no 857 0.270392256304175 1283 138402
SGTC_2430 5571206 200 µM 0.610738494463728 0.253361062172334 no 858 0.270686358683282 1360 1731771
SGTC_819 1013-0258 27.7 µM 0.609762638895183 0.253683309657032 no 859 0.271009526956487 1321 5753198
SGTC_1690 st023502 41.2 µM 0.607280956066154 0.254503780834112 no 860 0.271832237216574 1331 24207482
SGTC_839 0122-0028 230 µM 0.605317780543317 0.255153811464368 no 861 0.272483934724338 1322 759448
SGTC_3011 9081274 71.4286 µM 0.603931701445944 0.255613281017291 no 862 0.272944525575459 1327 6625322
SGTC_2066 5222451 176 µM 0.603430886069324 0.255779401865817 no 863 0.273111040248409 1313 2281147
SGTC_2218 6965428 192.983 µM 0.603072078568083 0.255898453236083 no 864 0.273230370076571 1329 675684
SGTC_2836 9010338 19.48 µM 0.601956143653718 0.256268902197961 no 865 0.273601665348577 1223 2994051
SGTC_2704 st078022 71.1 µM 0.60166184993299 0.256366643350728 no 866 0.273699624713487 1396 54697681
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.601303784484568 0.256485590632941 no 867 0.273818834691608 1357 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1954 st077032 68.9 µM 0.600753587073731 0.256668419064361 no 868 0.274002060782713 1265 698907
SGTC_2561 acetosyringone 100 µM 0.599533643781829 0.257074043323457 no 869 0.274408540853792 1317 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_604 1000-0114 314 µM 0.599085809845872 0.25722302919217 no 870 0.274557831921081 1401 1572745
SGTC_735 3076-0345 636 µM 0.598703476942241 0.257350259618285 no 871 0.27468531909598 1412 2888990
SGTC_518 1021-0119 62.6 µM 0.598519289106716 0.257411564200238 no 872 0.274746746112945 1283 1097762
SGTC_1527 coumarin 137 µM 0.597688274406809 0.257688251206706 no 873 0.275023975386323 1384 323 A hepatotoxic, DNA x-linker.
SGTC_57 miconazole 162.5 nM 0.59663885720925 0.258037875974978 no 874 0.27537426122889 1269 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1436 4092-1007 8.32 µM 0.596179262944998 0.258191072240027 no 875 0.275527738677813 1319 2881121
SGTC_1158 4092-0494 91.8 µM 0.595152207894096 0.258533590187217 no 876 0.275870866630105 1433 1148199
SGTC_1094 duloxetine 25.4 µM 0.593601176731571 0.259051297338385 no 877 0.276389446901666 1347 60834 A selective serotonin reuptake inhibitor.
SGTC_1939 st074455 53.6 µM 0.593110949863334 0.259215037942957 no 878 0.27655345142877 1443 1644229
SGTC_2929 9013348 24.6 µM 0.592577281575953 0.259393349205043 no 879 0.276732043423946 1361 2995952
SGTC_2102 5377816 72.7585 µM 0.59243574699443 0.259440649902322 no 880 0.276779417424237 1396 1379702
SGTC_2447 5741742 33.78 µM 0.591211280974381 0.259850050983889 no 881 0.277189432535721 1426 1776504
SGTC_390 dec-rvkr-cmk 16.7 µM 0.590413046144807 0.260117120713919 no 882 0.277456883107273 1403 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_3202 9113761 49.47 µM 0.590263787456471 0.260167074696372 no 883 0.277506906597863 1460 4798415
SGTC_2785 7756463 72.73 µM 0.589738808322606 0.260342814283786 no 884 0.277682886396915 1309 2201551
SGTC_2389 9091542 195.52 µM 0.589681857995535 0.260361882388219 no 885 0.277701980160372 1340 3626624 YOL127W RPL25
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.588627664949328 0.260714977098216 no 886 0.278055535718276 1330 75037 A free radical scavenger.
SGTC_1365 1672-3266 55.4 µM 0.5881552166585 0.260873300330437 no 887 0.278214056788628 1358 6415873
SGTC_153 4077-0274 519.67 µM 0.587841951270035 0.26097830667447 no 888 0.278319191344527 1457 3121976
SGTC_1211 1056-0033 32.3 µM 0.586493508591169 0.261430551732931 no 889 0.278771961258358 1362 6741922
SGTC_341 1486-1430 230 µM 0.586276323920644 0.261503429439661 no 890 0.278844919397363 1319 2054753 YPL210C SRP72
SGTC_2189 6047310 154.431 µM 0.586076715975644 0.261570418360675 no 891 0.278911981237252 1300 711535
SGTC_3278 9139605 49.47 µM 0.584378650324692 0.262140649388495 no 892 0.279482793687366 1393 7958859
SGTC_2245 6637752 200 µM 0.583374774016892 0.262478062592555 no 893 0.2798205178667 1365 681890
SGTC_1318 1280-3875 124 µM 0.583037919978769 0.262591332515055 no 894 0.279933886682136 1356 373245
SGTC_2860 9025725 38.96 µM 0.583002815116538 0.262603138250927 no 895 0.279945702566258 1315 40546248
SGTC_1251 0490-5699 265 µM 0.582280897243282 0.262845978841058 no 896 0.280188745247195 1396 3883818
SGTC_895 0964-0006 13.7 µM 0.581450057756918 0.263125600826981 no 897 0.280468584222574 1337 6738897
SGTC_3155 9099265 49.47 µM 0.579515894094498 0.263777138737474 no 898 0.281120562612442 1352 25236499
SGTC_1453 4237-0541 195 µM 0.57895263641019 0.263967030982495 no 899 0.281310566116236 1354 739892
SGTC_2519 cryptotanshinone 88.04 µM 0.578950427081393 0.263967775955304 no 900 0.281311311510331 1377 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_912 3474-0017 2.18 µM 0.575792019115859 0.265033867330089 no 901 0.282377884310416 1456 3360550
SGTC_988 1497-1057 103 µM 0.573281265807968 0.265882906708898 no 902 0.283227133984978 1401 3533044
SGTC_941 3237-0776 460 µM 0.572698625561998 0.266080129888662 no 903 0.283424384119249 1434 760008
SGTC_1750 st081859 2.357 µM 0.572237082806759 0.266236414254502 no 904 0.283580683993442 1384 5291695
SGTC_1828 st055811 49 µM 0.571974253238568 0.266325432516651 no 905 0.283669708778039 1352 5877589
SGTC_2345 9052315 157.45 µM 0.571291583665412 0.266556717562496 no 906 0.283901002936121 1401 6469265
SGTC_773 4358-1457 44.6 µM 0.571095968705402 0.26662300965289 no 907 0.283967295553423 1432 1186886
SGTC_1790 st045711 43.5 µM 0.571088118945784 0.266625670037362 no 908 0.283969955939663 1476 585119
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.569419737734884 0.26719141028069 no 909 0.284535662623617 1382 7104
SGTC_2581 avocatin a 64 µM 0.568294410779699 0.267573345242015 no 910 0.284917536789206 1395 6710728 A skin care supplement.
SGTC_1130 3454-2858 15.9 µM 0.566366627687529 0.268228272100071 no 911 0.285572288022856 1388 715628 YIL048W NEO1
SGTC_1332 1480-0653 17.5 µM 0.566365123014111 0.268228783598474 no 912 0.285572799348916 1349 5749438
SGTC_2221 6807166 181.081 µM 0.566298050162751 0.268251584829666 no 913 0.285595592841816 1366 674925
SGTC_1215 3852-0577 11.2 µM 0.565698767151009 0.268455352710084 no 914 0.28579928672975 1489 2884876
SGTC_1573 oleylamine 1.06 µM 0.565580526589957 0.268495565991127 no 915 0.28583948438085 1390 5356789 An amine of the fatty acid oleic acid.
SGTC_1271 0832-2808 169 µM 0.564186940006335 0.268969748916587 no 916 0.286313457483461 1413 3663794
SGTC_193 1273-0060 1.558 µM 0.563573700673523 0.269178543358336 no 917 0.286522144632666 1300 2847393 YHR072W ERG7
SGTC_2642 cholecalciferol 100 µM 0.563261199253869 0.269284974453526 no 918 0.28662851753473 1406 9821465 A vitamin D precursor, similar to steriods.
SGTC_2584 androsterone 48.74 µM 0.56265118834493 0.269492791512183 no 919 0.286836214155015 1413 2754130 A steroid.
SGTC_1891 st059073 26.2 µM 0.561082744362493 0.270027494031931 no 920 0.28737056544314 1459 688754
SGTC_1248 0469-0687 58.6 µM 0.560437498121555 0.270247620701261 no 921 0.287590530238169 1446 4017482
SGTC_2994 9053520 71.4286 µM 0.559759238363354 0.270479106671431 no 922 0.287821835126077 1460 4647384
SGTC_1326 1431-2094 10.8 µM 0.558303822820364 0.270976165395789 no 923 0.288318467476813 1370 616278
SGTC_2202 7226349 200 µM 0.555671018871074 0.271876486312951 no 924 0.289217886002318 1368 844334
SGTC_2464 5717415 7.67 µM 0.554958985809489 0.272120230523257 no 925 0.289461357144139 1332 5285744
SGTC_1007 4101-0031 70 µM 0.553104666090522 0.272755513399375 no 926 0.290095870867079 1453 1146276
SGTC_884 0851-0618 334 µM 0.552236235354277 0.273053287260208 no 927 0.290393255678916 1406 9642473
SGTC_2905 7799065 20.05 µM 0.552019320459073 0.27312768976403 no 928 0.290467558135371 1428 1296806
SGTC_717 1532-0246 73.2 µM 0.551126259833616 0.273434118210475 no 929 0.290773562584193 1379 9561992
SGTC_583 1488-1091 88.9 µM 0.548747277648717 0.274251228222075 no 930 0.291589448143582 1478 4303273
SGTC_896 0964-0007 44.5 µM 0.548496628155348 0.274337389072086 no 931 0.291675471940283 1398 6756758
SGTC_1089 terbinafine 2.25 µM 0.548324818756447 0.274396456330862 no 932 0.29173444436881 1448 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_320 4092-0846 5.34 µM 0.54824539280766 0.274423764718018 no 933 0.291761708673164 1454 1359356
SGTC_183 3914-0051 30.55 µM 0.546524520100443 0.275015767737862 no 934 0.292352718747873 1502 1596232
SGTC_1936 st074407 74.3 µM 0.546112945271804 0.275157448104657 no 935 0.29249415091674 1416 809813
SGTC_2140 5586273 200 µM 0.546041974326269 0.275181882749301 no 936 0.292518542344422 1408 854421
SGTC_2469 5655019 90.81 µM 0.545953137425881 0.275212469983655 no 937 0.292549075309117 1515 2788239
SGTC_3018 9082602 49.47 µM 0.545471445230727 0.275378349482736 no 938 0.29271465718956 1404 17332089
SGTC_2315 7733312 200 µM 0.545383505799594 0.27540863834065 no 939 0.292744891101187 1396 726316
SGTC_2804 7954240 19.48 µM 0.544908541012496 0.275572258140841 no 940 0.292908210867506 1471 828705
SGTC_134 0269-0018 6.916 µM 0.543431770042072 0.276081293589258 no 941 0.293416278223957 1362 4378915
SGTC_2190 6049624 200 µM 0.543244400594584 0.276145911872507 no 942 0.29348076986706 1414 2265554
SGTC_920 mycophenolic acid 780.421 nM 0.543191465060281 0.276164169146494 no 943 0.293498991207243 1420 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2106 5357045 167.29 µM 0.54037507942267 0.277136383739498 no 944 0.294469195178795 1489 668842
SGTC_1039 k821-0043 94 µM 0.540125575857207 0.277222592903509 no 945 0.294555216867803 1490 15992768
SGTC_363 0455-0021 3.06 µM 0.539263811636277 0.277520452930064 no 946 0.294852417657891 1453 4597466
SGTC_1751 st044839 27.194 µM 0.539056829200788 0.277592017587967 no 947 0.294923821271364 1439 5291326
SGTC_2053 5265679 138 µM 0.538660231959643 0.277729167190798 no 948 0.295060659369827 1376 764595
SGTC_1138 3761-0006 1.03 µM 0.538307752758417 0.277851087846554 no 949 0.29518229994302 1437 12061087
SGTC_1976 st070609 63.5 µM 0.537967698864098 0.277968735413576 no 950 0.295299674419249 1388 682556
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.537323502453045 0.278191673004851 no 951 0.295522086910003 1429 756377
SGTC_474 dl-dihydrosphingosine 5 µM 0.537191656897566 0.278237311653204 no 952 0.295567616835643 1470 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_922 1866-0035 480 µM 0.536699166769053 0.278407820545994 no 953 0.295737715847253 1493 3156169
SGTC_1116 jasmonic acid 1.58368 µM 0.535782322032858 0.27872538416518 no 954 0.296054500595194 1479 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_258 haloperidol 50.781 µM 0.535367969270043 0.278868959603815 no 955 0.296197717283828 1373 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2685 mycophenolic acid 18.85 µM 0.534278880731162 0.279246506093568 no 956 0.296574300785295 1457 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1270 0831-1170 17.3 µM 0.533385943614605 0.279556239394427 no 957 0.296883222866621 1390 6764716
SGTC_1324 1418-0026 34.4 µM 0.532890716121534 0.27972809094177 no 958 0.29705461608838 1451 1372513
SGTC_1140 3229-1848 2.98 µM 0.531820207272893 0.280099749030268 no 959 0.297425262906944 1453 2849525
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.529765819958445 0.280813658569179 no 960 0.298137153093741 1414 803109
SGTC_1768 st044301 37.178 µM 0.527266301207183 0.281683438068497 no 961 0.299004336207953 1412 3931349
SGTC_2619 obliquin 87.91 µM 0.526402203595821 0.281984427551014 no 962 0.299304392476263 1469 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3273 9137859 49.47 µM 0.525207887329944 0.282400696319822 no 963 0.299719341255484 1493 2377234
SGTC_585 0kpi-0023 191 µM 0.524099331316571 0.282787338390059 no 964 0.300104726813807 1492 64601
SGTC_1834 st055981 52.8 µM 0.523081411323313 0.283142592246907 no 965 0.300458800342213 1528 471719 YDL150W RPC53
SGTC_1724 st037281 8.293 µM 0.522876925259859 0.283213983659992 no 966 0.300529951577356 1438 574124 YDL195W SEC31
SGTC_846 0335-0850 148 µM 0.522702588768296 0.283274855890263 no 967 0.300590618231508 1432 6819598
SGTC_756 0508-1999 28.3 µM 0.522089945292598 0.283488819408897 no 968 0.300803853411185 1381 6753853
SGTC_3304 9125678 46.087 µM 0.521585487512893 0.283665057590671 no 969 0.30097948495628 1437 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_265 mycophenolic acid 32.932 µM 0.519695858162774 0.284325687603345 no 970 0.301637787080313 1504 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1051 3253-3903 78 µM 0.519532375062507 0.284382877187292 no 971 0.30169477114567 1419 5509239
SGTC_1783 st039459 87.517 µM 0.518125415909544 0.284875286073993 no 972 0.302185384190256 1594 729761
SGTC_882 0843-0131 351 µM 0.518004698125431 0.284917553936982 no 973 0.302227495705452 1463 5425421
SGTC_2955 9076254 12.21 µM 0.517295215469899 0.28516603108994 no 974 0.302475046740462 1460 16459619
SGTC_3255 9139072 49.47 µM 0.516908047442035 0.285301669785953 no 975 0.302610174837152 1462 17646060
SGTC_979 1426-2828 121 µM 0.516385965168045 0.285484622378911 no 976 0.302792433077132 1531 747872
SGTC_525 k781-2675 26.7 µM 0.515469948602423 0.285805755743369 no 977 0.3031123319943 1470 3651118 YDL195W SEC31
SGTC_2257 7960413 200 µM 0.514875007790642 0.286014419655654 no 978 0.30332018311123 1516 2974689 YIL048W NEO1
SGTC_1276 0871-0068 94.2 µM 0.514740543331537 0.286061590476881 no 979 0.303367169025618 1514 3414906
SGTC_938 3126-1755 342 µM 0.514682092882504 0.286082096346514 no 980 0.303387594379498 1486 1777771
SGTC_295 k015-0027 31 µM 0.513510151623624 0.286493389766659 no 981 0.30379725573725 1454 3887424
SGTC_1578 josamycin 24.2 µM 0.512106576705644 0.286986344047469 no 982 0.30428821098125 1397 5282165 A P450 substrate.
SGTC_1917 st066507 28.5 µM 0.511146995128936 0.287323593000482 no 983 0.304624065399244 1469 3156428
SGTC_1126 isoteolin 1.0172 µM 0.51037073699514 0.287596549288588 no 984 0.304895877018508 1411 133323
SGTC_2283 7944793 200 µM 0.508249301519659 0.288343135960564 no 985 0.305639259899543 1396 2970533
SGTC_1216 1165-0504 9.65 µM 0.505246292220145 0.28940153031023 no 986 0.306692930005266 1520 6304004
SGTC_2763 lisinopril 49.32 µM 0.505110164360713 0.28944955104758 no 987 0.306740731338547 1449 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2853 9015042 58.44 µM 0.504607515555334 0.289626898867872 no 988 0.306917265068208 1391 6457456
SGTC_970 1315-0089 19.5 µM 0.503824138629995 0.28990339666143 no 989 0.307192481720462 1410 6811083 YLR033W RSC58
SGTC_2115 tiliquinol 12.7705 µM 0.503678549049501 0.289954797054263 no 990 0.307243642352388 1497 71208 A bioactive hydroxyquinoline.
SGTC_2967 9089538 49.85 µM 0.502273934866029 0.290450915359768 no 991 0.307737420734315 1621 728216
SGTC_2560 caryophyllene 100 µM 0.501121866955523 0.290858129154035 no 992 0.308142679107887 1492 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1073 triclabendazole 3.09 µM 0.501013887593354 0.290896309576675 no 993 0.308180674582953 1506 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_3175 9106517 49.47 µM 0.500872435715813 0.2909463290899 no 994 0.30823045138294 1434 41468073
SGTC_3271 9137798 49.47 µM 0.498248342252803 0.291874976047287 no 995 0.309154506507355 1544 6498326
SGTC_1884 5633444 25 µM 0.495276169508441 0.292928470042094 no 996 0.310202595049623 1501 5724239
SGTC_731 3966-0296 387 µM 0.495194014667125 0.292957615075654 no 997 0.310231587583484 1495 660956
SGTC_1727 st034309 9.9045 µM 0.494937785584207 0.293048522867067 no 998 0.310322018684089 1613 870305
SGTC_514 4466-0038 2.65 nM 0.494072547288388 0.29335559835188 no 999 0.310627472538833 1522 5722064
SGTC_1908 st060353 56.5 µM 0.493767394418157 0.293463933511824 no 1000 0.310735231388811 1652 4227716
SGTC_575 k072-0246 11.9 µM 0.493502348134055 0.293558045095123 no 1001 0.310828840548557 1497 6796779
SGTC_431 k089-0097 107 µM 0.492393502975131 0.293951920887342 no 1002 0.311220595670125 1443 5499420
SGTC_910 3454-3003 490 µM 0.489605060023051 0.294943489368871 no 1003 0.312206697584844 1472 820824
SGTC_2625 euphol 100 µM 0.488980732261653 0.295165710906926 no 1004 0.312427668961217 1614 6708538 A triterpene alcohol.
SGTC_210 3551-0445 56.827 µM 0.48789969445424 0.295550674778364 no 1005 0.312810445473573 1532 2865180 YOR207C RET1
SGTC_2492 derrusnin 100 µM 0.487068084312059 0.29584697301228 no 1006 0.313105041473371 1435 1715307 Part of coumarin class of compounds.
SGTC_1135 dihydrocapsaicin 536.708 nM 0.486195824359955 0.296157901077305 no 1007 0.313414165817088 1441 107982 A Capsaicinoid.
SGTC_2363 9053361 176 µM 0.485631522856539 0.296359133304997 no 1008 0.313614221170786 1611 6469797 YMR079W SEC14
SGTC_1556 plumbagin 1.48 µM 0.484802109161596 0.296655019353197 no 1009 0.313908363224091 1468 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_925 2064-1272 59.6 µM 0.48383649395558 0.296999664436239 no 1010 0.314250956603627 1477 6815817
SGTC_1567 st069303 68.4 µM 0.483711706206387 0.297044216743414 no 1011 0.314295242092744 1501 5581319
SGTC_1694 st024011 44.9 µM 0.483471870101727 0.297129852735122 no 1012 0.314380364197225 1536 2787533
SGTC_2201 6605497 169.863 µM 0.480983468768911 0.298019027791178 no 1013 0.315264123951443 1558 670741
SGTC_107 0358-0022 2.6945 µM 0.480805388062019 0.298082707456394 no 1014 0.315327410233796 1576 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_156 3474-0145 5.642 µM 0.479572169501006 0.298523862617023 no 1015 0.315765819790041 1597 2265471
SGTC_2322 7413319 38.22 µM 0.47775212993413 0.299175481342259 no 1016 0.316413318080587 1551 1840400
SGTC_2748 diazoxide 86.69 µM 0.476983807095633 0.299450753362387 no 1017 0.316686826215885 1549 3019 A potassium channel activatior.
SGTC_1832 st054113 55 µM 0.475986662982916 0.299808177785566 no 1018 0.317041939784902 1531 1251267
SGTC_2706 st078239 82.5 µM 0.475293676842639 0.300056691072394 no 1019 0.317288832691255 1494 15434492
SGTC_244 nsc-207895 1.295 µM 0.4747191099216 0.300262808415379 no 1020 0.317493597592016 1432 42640
SGTC_1213 1315-0166 115 µM 0.474264334427717 0.300425997727565 no 1021 0.317655710675848 1460 768401
SGTC_3041 9091929 49.47 µM 0.474251606726592 0.30043056544706 no 1022 0.317660248202007 1561 25236887
SGTC_101 0490-5701 117.494 µM 0.473987779725799 0.300525254789441 no 1023 0.31775431078254 1573 4661669
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.471182987716233 0.301532746229477 no 1024 0.318755033169437 1559 688788
SGTC_1760 st045453 10.4495 µM 0.470718474472318 0.301699747641324 no 1025 0.318920894857114 1571 3323419 YIL048W NEO1
SGTC_3106 9121286 49.47 µM 0.469851976961219 0.30201138119235 no 1026 0.319230388199943 1571 15943471
SGTC_960 1222-0186 7.7 µM 0.469035456501947 0.302305172861355 no 1027 0.319522146206187 1609 3126296
SGTC_2743 auranofin 4.32 µM 0.467836864640749 0.302736669466051 no 1028 0.319950627850288 1552 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2678 equilin 100 µM 0.467134756114254 0.302989558668177 no 1029 0.320201734550065 1626 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_3183 9108214 49.47 µM 0.466126732162341 0.303352799314324 no 1030 0.32056239485009 1499 4974831
SGTC_955 1216-0110 33 µM 0.46528238437727 0.303657209070642 no 1031 0.320864624014775 1464 3619719
SGTC_1637 st007924 17.4 µM 0.465000650777279 0.303758811832461 no 1032 0.320965495278988 1506 683336
SGTC_2885 9057732 51.95 µM 0.463176049540302 0.304417192279382 no 1033 0.321619091068438 1540 6471414
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.462792852006312 0.304555544126237 no 1034 0.321756427658154 1541 6857784
SGTC_2975 9084847 53.72 µM 0.46263500635647 0.304612541763115 no 1035 0.321813006043712 1525 27211724
SGTC_48 0382-0018 55 µM 0.459406413840373 0.305779417107956 no 1036 0.322971171634261 1670 762596
SGTC_2629 bisabolol 100 µM 0.458220437802656 0.306208548180904 no 1037 0.323397038985511 1623 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1845 st056753 3.01 µM 0.458196574604156 0.306217185522481 no 1038 0.323405610302625 1475 5375839
SGTC_527 4476-4215 268 µM 0.458160156788089 0.306230367245425 no 1039 0.323418691238148 1565 4418754
SGTC_2806 7952793 58.44 µM 0.4577384313067 0.306383032460686 no 1040 0.323570186942026 1575 2972490
SGTC_3208 9114115 49.47 µM 0.453166468535549 0.308040242537223 no 1041 0.325214437861735 1469 650895
SGTC_742 0kpi-0133 140 µM 0.451452580901607 0.308662491947224 no 1042 0.325831697013989 1652 2728852
SGTC_699 0375-0592 111 µM 0.450630686462929 0.30896108668268 no 1043 0.326127873091353 1600 762578
SGTC_676 falcarinol 140 µM 0.450334768519596 0.309068624776752 no 1044 0.326234536303175 1667 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_3118 9124250 49.47 µM 0.44967187643931 0.309309582526172 no 1045 0.326473526410511 1525 1504786
SGTC_1134 3477-0009 42.5 µM 0.448571252467024 0.309709834625769 no 1046 0.326870487745182 1739 3973534
SGTC_2859 9028643 45.46 µM 0.448289782725331 0.309812229968698 no 1047 0.326972036746324 1580 17151580
SGTC_1027 k015-0025 8.67 µM 0.447686798688048 0.310031638051545 no 1048 0.327189625194162 1506 3598955
SGTC_2138 5575593 77.673 µM 0.446983955592981 0.310287467294984 no 1049 0.327443322197334 1519 762213
SGTC_1448 4255-0083 152 µM 0.446094690657987 0.310611284177864 no 1050 0.327764423918917 1699 5399660
SGTC_961 1252-1571 372 µM 0.444924584228115 0.311037590300537 no 1051 0.328187127843421 1674 6813498
SGTC_2541 muurolladie-3-one 83.07 µM 0.44438272846678 0.311235091160166 no 1052 0.328382949212801 1585 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_400 oxethazaine 37.5 µM 0.444275737068755 0.311274094853552 no 1053 0.328421620433484 1540 4621 A local anesthetic.
SGTC_3073 9114972 49.47 µM 0.443532409855218 0.311545133124895 no 1054 0.328690341087181 1668 41905075
SGTC_455 paf C-16 10 µM 0.443459297360188 0.311571797542877 no 1055 0.3287167768161 1557 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1744 st037937 38.9 µM 0.442972878668953 0.311749221527561 no 1056 0.328892675991907 1615 1016152
SGTC_1020 4335-0961 93.3 µM 0.439705813700783 0.312942033000257 no 1057 0.330075095675287 1496 669075
SGTC_1509 1326-1131 80 µM 0.43970080097465 0.312943864665493 no 1058 0.330076911195187 1639 768313
SGTC_1313 1220-0047 237 µM 0.438788566543463 0.313277274716711 no 1059 0.330407372807262 1630 3528706
SGTC_2204 7233102 200 µM 0.437489977567365 0.313752155760976 no 1060 0.330878021504571 1590 2172480
SGTC_484 loperamide 105 µM 0.436541168285194 0.314099321111004 no 1061 0.331222068389752 1567 3955 An opioid-receptor agonist.
SGTC_3039 9090270 49.47 µM 0.433488413702761 0.315217426599018 no 1062 0.332329990781801 1667 17173750
SGTC_2696 st077691 74.316 µM 0.433156278626371 0.315339177187927 no 1063 0.332450619704388 1588 757133
SGTC_649 1123-0311 367 µM 0.432897081495522 0.315434204883921 no 1064 0.332544770180012 1602 693629 YIL048W NEO1
SGTC_1480 1070-0044 41.2 µM 0.432818508041042 0.315463014151358 no 1065 0.332573313200629 1627 3124987
SGTC_3082 9117008 49.47 µM 0.43219998814512 0.315689836074795 no 1066 0.332798033988394 1575 41448529
SGTC_2295 7971645 200 µM 0.430842374513242 0.316187939821225 no 1067 0.333291493047106 1642 2978226 YKL099C UTP11
SGTC_2701 st077767 14.721 µM 0.427904269651602 0.317267062246614 no 1068 0.334360409224907 1567 5721188
SGTC_2348 9022543 33.42 µM 0.427171457181891 0.317536456125935 no 1069 0.334627224606873 1617 3162678 YDL140C RPO21
SGTC_447 ml7 120 µM 0.426824471507167 0.317664047477336 no 1070 0.334753590464029 1661 4216 Selective myosin light chain kinase inhibitor.
SGTC_1209 2323-2347 50.3 µM 0.425760377787357 0.318055464212877 no 1071 0.335141230652895 1617 5412760
SGTC_1254 0550-0035 264 µM 0.42453645721806 0.318505923141554 no 1072 0.335587311583275 1667 15121435
SGTC_1881 5652484 16 µM 0.423969110438832 0.318714823880358 no 1073 0.335794170492693 1695 2255129
SGTC_213 1246-0773 967 nM 0.42384523332375 0.3187604438988 no 1074 0.335839343642879 1610 6251622
SGTC_2958 9077254 16.72 µM 0.423271722384249 0.3189716856005 no 1075 0.336048511604814 1589 16457351
SGTC_3333 9141820 12.094 µM 0.420699776249146 0.319919734867973 no 1076 0.33698716228393 1576 1939433
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.42050237237645 0.319992548960424 no 1077 0.337059248336427 1568 4000243
SGTC_2379 9035213 200 µM 0.419003326344107 0.320545710922561 no 1078 0.33760685067759 1741 646551
SGTC_2237 6667747 47.222 µM 0.416891647498606 0.321325616582493 no 1079 0.338378831597065 1580 729940 YDL015C TSC13
SGTC_3232 9132874 49.47 µM 0.415813551528534 0.321724093692977 no 1080 0.338773220882948 1551 3784940
SGTC_2796 7949634 45.45 µM 0.415376525308277 0.321885682253163 no 1081 0.338933144296625 1571 2971588
SGTC_2520 obtusaquinone 4.71 µM 0.414705301696033 0.322133929886296 no 1082 0.339178825384711 1691 5967872
SGTC_2167 5876490 200 µM 0.414306178901079 0.322281580462065 no 1083 0.339324944636771 1776 686534
SGTC_223 busulfan 5 mM 0.41382492324421 0.322459652376083 no 1084 0.339501164944123 1652 2478 A DNA alkylator.
SGTC_2186 6124449 200 µM 0.413524992055085 0.322570652088702 no 1085 0.339611007832481 1647 3834182 YLR033W RSC58
SGTC_23 0213-0011 39.996 µM 0.41270501495652 0.322874193134912 no 1086 0.33991137507021 1698 627608
SGTC_2358 9037157 4 µM 0.412147049910904 0.323080809444262 no 1087 0.340115822353345 1647 2388925
SGTC_656 4090-1979 187 µM 0.409737632483709 0.323973651010781 no 1088 0.340999210541048 1727 22330961
SGTC_2123 5259487 200 µM 0.407553092728891 0.324784037587122 no 1089 0.341800903934052 1719 2173474
SGTC_3100 9120536 49.47 µM 0.405179828901409 0.325665374788205 no 1090 0.342672665410027 1672 16421196
SGTC_12 0849-0099 9.267 µM 0.404711584232186 0.325839377873421 no 1091 0.342844763035081 1684 6071388
SGTC_1950 st077106 7.18 µM 0.401038459015293 0.327205651322644 no 1092 0.344195904428425 1589 13831864
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.398421303463655 0.328180557059176 no 1093 0.345159828548311 1699 5282309
SGTC_3047 9092122 49.47 µM 0.39773120240604 0.328437819188121 no 1094 0.34541416732522 1588 17173831
SGTC_2192 5915882 198.485 µM 0.397570387421477 0.32849778094946 no 1095 0.3454734461958 1624 2876149
SGTC_3185 9108267 49.47 µM 0.397402402123189 0.328560420963627 no 1096 0.345535372201396 1575 4910486
SGTC_343 4130-2827 29.8 µM 0.396634567496934 0.328846800031002 no 1097 0.345818478937815 1600 1118244
SGTC_2922 7999257 32.47 µM 0.395547613493596 0.329252372799885 no 1098 0.346219394934303 1592 2988377
SGTC_2472 5377652 49.4 µM 0.395119194562847 0.32941228307383 no 1099 0.346377461893746 1606 1610903
SGTC_2481 5478948 45.16 µM 0.394009502824905 0.329826628079829 no 1100 0.346787011671382 1619 77792
SGTC_2350 9023895 38.85 µM 0.392902452301332 0.330240195067903 no 1101 0.347195765133524 1714 2997209
SGTC_1970 st070122 35.8 µM 0.390773985212969 0.331035920895881 no 1102 0.347982152917781 1688 102928
SGTC_2848 9016370 25.97 µM 0.38989710274207 0.331363965116371 no 1103 0.348306318192187 1781 7894410
SGTC_1253 0550-0034 176 µM 0.389593684646869 0.331477504841038 no 1104 0.348418511397677 1637 5969915
SGTC_598 3937-0236 20.2 µM 0.388123170980163 0.332027993592225 no 1105 0.348962442725761 1700 1379313
SGTC_165 k038-0023 64.381 µM 0.388105742495886 0.332034520145888 no 1106 0.34896889124769 1598 46368543
SGTC_932 2857-0803 154 µM 0.387616554427404 0.332217730247636 no 1107 0.349149908136768 1755 674898
SGTC_3310 9130229 44.1445 µM 0.38749325884473 0.332263913084484 no 1108 0.349195537281313 1722 7761258
SGTC_3281 9140613 49.47 µM 0.384546106619806 0.333368584909547 no 1109 0.35028686486053 1555 16013766
SGTC_2482 5981709 142.65 µM 0.384405287465354 0.333421404001816 no 1110 0.350339041097454 1680 877755
SGTC_747 3448-8087 38.7 µM 0.384060429600473 0.333550768813254 no 1111 0.350466829573242 1610 5168703
SGTC_1871 st057448 67.3 µM 0.383832738212137 0.333636192398899 no 1112 0.350551210815387 1730 691747
SGTC_1758 st042942 75.2445 µM 0.383577523101301 0.33373195238523 no 1113 0.350645800971467 1679 669317
SGTC_2903 5923464 63.88 µM 0.381807331458389 0.3343964488311 no 1114 0.351302140153394 1683 2876576
SGTC_739 1486-1183 203 µM 0.381320974843623 0.334579108912816 no 1115 0.351482545814311 1780 4346692
SGTC_2722 naftopidil 47.16 µM 0.380613944540103 0.334844716850948 no 1116 0.35174486627098 1702 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_977 1348-1378 135 µM 0.37687666371023 0.336250060098587 no 1117 0.35313263227347 1626 X977
SGTC_610 4215-0184 155 µM 0.376032153019244 0.336567942606469 no 1118 0.353446496306473 1681 5605015
SGTC_852 0418-0143 439 µM 0.373105820765618 0.337670346759478 no 1119 0.354534843321689 1760 5369229
SGTC_3096 9117468 49.47 µM 0.371944538419351 0.338108210552889 no 1120 0.354967071681013 1676 41316311
SGTC_1614 st002383 48.6 µM 0.370332626458827 0.338716348153182 no 1121 0.355567333398712 1670 1947235
SGTC_2041 5107442 45.335 µM 0.370131105221696 0.338792407135459 no 1122 0.355642403354235 1762 793005
SGTC_3236 9132701 49.47 µM 0.369387769099423 0.339073016965282 no 1123 0.35591935661381 1626 24282524
SGTC_2628 lathosterol 100 µM 0.368523347348331 0.339399448993106 no 1124 0.356241519773868 1671 6710616
SGTC_1651 st011928 86.1 µM 0.368123680699018 0.339550416081661 no 1125 0.356390507090418 1685 720198
SGTC_3336 9143619 71.43 µM 0.366417871315703 0.340195044971271 no 1126 0.357026643129982 1743 45595730
SGTC_886 0866-0150 153 µM 0.365119319347546 0.340686083871234 no 1127 0.35751117011444 1810 271463
SGTC_446 go6976 132 µM 0.361652064813997 0.341998524989608 no 1128 0.358806026165529 1791 3501 A protein kinase C inhibitor.
SGTC_1902 st060212 70.5 µM 0.360824405018873 0.342312097768358 no 1129 0.359115358775387 1662 688944
SGTC_1769 st044406 64.4 µM 0.360800854089736 0.342321022024593 no 1130 0.359124162138879 1691 670903
SGTC_3105 9121040 49.47 µM 0.360386676764167 0.342477982430373 no 1131 0.359278994305379 1699 41448907
SGTC_2782 7736369 71.43 µM 0.359363859931106 0.342865714909631 no 1132 0.35966145352246 1667 2950836 YOL077C BRX1
SGTC_2050 5263056 171 µM 0.358924105117813 0.343032469403006 no 1133 0.359825933128777 1815 763468 YGL055W OLE1
SGTC_2432 5630864 12.22 µM 0.356749359919472 0.343857579112536 no 1134 0.360639724895034 1648 5714970
SGTC_2378 9074213 121.43 µM 0.354674258523062 0.344645577453887 no 1135 0.361416818771094 1669 657714
SGTC_2952 9073731 13.78 µM 0.354245530473079 0.344808466700412 no 1136 0.361577442309067 1632 16457353
SGTC_1885 st057546 99.9 µM 0.354070093129048 0.344875129971036 no 1137 0.361643177180541 1783 702008
SGTC_1399 3562-5772 25 µM 0.353996329373866 0.344903160408472 no 1138 0.361670817047845 1689 23847490
SGTC_1896 st058441 89 µM 0.353018016892117 0.345275002402668 no 1139 0.362037466749621 1649 688759
SGTC_3355 9151058 44.0485 µM 0.352363271832363 0.345523944723362 no 1140 0.362282921360065 1705 17015728
SGTC_2159 5658611 73.75 µM 0.350355930184433 0.346287577417842 no 1141 0.363035797780087 1801 793844
SGTC_2158 5657123 3.6195 µM 0.35028039451546 0.346316324915696 no 1142 0.363064138653151 1746 2858827
SGTC_1927 st060202 13.8 µM 0.349663270111083 0.346551224361229 no 1143 0.363295710908412 1825 688887
SGTC_2335 9018011 154.17 µM 0.348692755108029 0.346920756167953 no 1144 0.363659991946239 1796 6458208
SGTC_1503 4585-0012 61.3 µM 0.348168784104591 0.34712032313097 no 1145 0.363856714779829 1770 2922052
SGTC_2083 5306046 65.942 µM 0.346241235824201 0.34785484083076 no 1146 0.364580713644674 1685 539837
SGTC_3262 9137218 49.47 µM 0.343277445781394 0.348985346052802 no 1147 0.365694873370772 1703 17650664
SGTC_1808 st050063 61.5 µM 0.342995090711924 0.349093117454962 no 1148 0.365801076715729 1782 4011993
SGTC_883 0850-0245 24.6 µM 0.342952571079771 0.349109347722011 no 1149 0.365817070686824 1813 6823229 YPR165W RHO1
SGTC_1861 st057647 17.4 µM 0.341557078940087 0.349642177274109 no 1150 0.366342121283664 1847 688668
SGTC_273 hydroxyurea 18.1 mM 0.341152893427263 0.349796559571854 no 1151 0.366494241911488 1752 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.34066013227268 0.34998480773166 no 1152 0.366679727542053 1696 5106787 A p450 inhibitor.
SGTC_1773 st048542 73.5835 µM 0.34046636549992 0.35005884201141 no 1153 0.366752673950139 1634 3237138
SGTC_751 0833-0568 350 µM 0.3403868506192 0.350089224653692 no 1154 0.366782609912489 1742 6954252
SGTC_1505 k297-0037 20.6 µM 0.340083085588454 0.350205302130247 no 1155 0.366896979594222 1679 4089396
SGTC_2620 irigenin 100 µM 0.339469907150312 0.350439658121709 no 1156 0.367127881599913 1812 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1684 st024538 14.6195 µM 0.339111338422476 0.350576729009597 no 1157 0.367262928584222 1691 6732859
SGTC_692 k241-0027 77.8 µM 0.337876800966362 0.351048807187326 no 1158 0.367728015331933 1808 3600480
SGTC_1263 0774-1208 64.8 µM 0.337602392574656 0.351153770233835 no 1159 0.367831419464058 1864 906585
SGTC_842 0271-0008 11.1 µM 0.337593328197812 0.351157237612443 no 1160 0.367834835317624 1781 1221709
SGTC_105 0111-0055 734.78 µM 0.337346980264924 0.351251477356129 no 1161 0.367927673992682 1739 5179370
SGTC_871 0574-0004 149 µM 0.33684642428662 0.35144299187825 no 1162 0.368116337265629 1729 9551173
SGTC_131 0141-0277 33.849 µM 0.336797738555263 0.351461621228169 no 1163 0.368134688978342 1805 1547771
SGTC_625 k213-0058 121 µM 0.336715568774396 0.351493063890271 no 1164 0.368165662928996 1776 3655420
SGTC_634 1611-4317 11.2 µM 0.335056582529685 0.352128100065293 no 1165 0.368791201902666 1841 2843522
SGTC_1043 0916-0009 19.3 µM 0.332151752901098 0.353241020073247 no 1166 0.369887336539621 1904 3101130
SGTC_2708 st078559 56 µM 0.331488424769345 0.353495335832454 no 1167 0.370137791461623 1729 17250902
SGTC_2915 7971052 15.16 µM 0.329723476460953 0.35417232404074 no 1168 0.370804456604912 1787 5741558
SGTC_1464 k208-0027 110 µM 0.329486649605297 0.354263199793046 no 1169 0.370893941605784 1841 X1464
SGTC_1772 st048439 82.2 µM 0.329409457590531 0.354292821886308 no 1170 0.370923110109072 1730 2927068 YDL195W SEC31
SGTC_385 1494-0393 12.4 µM 0.329281869158458 0.354341785313867 no 1171 0.370971323504325 1770 3090647
SGTC_1173 0443-0020 122 µM 0.329222472931109 0.354364580073746 no 1172 0.370993768971412 1709 5331295
SGTC_3107 9121808 49.47 µM 0.32913574288034 0.35439786579624 no 1173 0.371026544509726 1845 662681
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.329038787745159 0.354435077072849 no 1174 0.371063185244737 1646 641818 YHR062C RPP1
SGTC_3095 9117207 49.47 µM 0.328656621797844 0.354581765482448 no 1175 0.371207622614483 1870 17015229
SGTC_476 mead acid 10 µM 0.328330354068401 0.354707015305731 no 1176 0.371330947938852 1739 5312531 An omega 9 fatty acid.
SGTC_480 am 92016 50 µM 0.325877148749245 0.355649270319499 no 1177 0.372258652714771 1711 2129 K+ channel blocker.
SGTC_870 0573-2213 57.6 µM 0.324602159265469 0.356139331792871 no 1178 0.37274109640004 1692 3916321
SGTC_2225 6654152 15.4 µM 0.323920672507427 0.356401369074216 no 1179 0.372999046340508 1789 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1560 lithocholic acid 53.1 µM 0.323528059091048 0.356552362966952 no 1180 0.37314768052997 1851 9903 A bile acid which acts as a detergent.
SGTC_2477 5967686 25.23 µM 0.322669953594872 0.356882457166844 no 1181 0.373472604755592 1700 776118
SGTC_1759 st043059 70 µM 0.321121636121533 0.357478331685135 no 1182 0.374059107322737 1666 669426
SGTC_3021 9087658 49.47 µM 0.319172978510565 0.358228772237841 no 1183 0.374797673113829 1841 25237042
SGTC_1074 carmofur 3.8 µM 0.318798799995461 0.358372933589147 no 1184 0.374939544151486 1765 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1874 staurosporine 7.6 µM 0.317367828536243 0.358924436138602 no 1185 0.375482257744309 1823 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2068 5226020 147 µM 0.316872693141751 0.35911533201617 no 1186 0.375670101414822 1714 1810509
SGTC_445 e6 berbamine 66 µM 0.316491302847716 0.359262398281103 no 1187 0.37581481274938 1743 6610268 A calcium/calmodulin antagonist.
SGTC_2259 7964009 200 µM 0.315714816615102 0.359561880216247 no 1188 0.376109489732627 1805 313134
SGTC_1606 st000094 49.2 µM 0.314048052664056 0.36020502332394 no 1189 0.376742271418899 1912 1242210
SGTC_2532 xanthone 78.9 µM 0.313985446023117 0.360229188656239 no 1190 0.376766046298991 1823 7020 An insecticide.
SGTC_1428 4049-0204 61.7 µM 0.313407754007945 0.36045219644484 no 1191 0.37698544695915 1855 X1428
SGTC_1708 st033234 31.827 µM 0.312568989216343 0.360776071258619 no 1192 0.37730407069762 1842 674664
SGTC_790 1575-0012 79.1 µM 0.311640466111288 0.361134721199938 no 1193 0.377656888583088 1887 378741 YLR208W SEC13
SGTC_1575 cyproterone acetate 48 µM 0.311414598232893 0.361221983063905 no 1194 0.377742728744841 1695 9880 An androgen receptor antagonist and liver toxin.
SGTC_459 nigericin 15.3 µM 0.310206100320635 0.3616889970967 no 1195 0.37820211590826 1781 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3114 9122766 49.47 µM 0.309994810947534 0.361770669314283 no 1196 0.378282451194071 1726 17176985
SGTC_1023 4482-3888 16 µM 0.308893157163451 0.362196606702492 no 1197 0.378701401118745 1860 3303168
SGTC_2172 5754775 163.918 µM 0.308847302874212 0.362214339257534 no 1198 0.37871884222417 1715 2263357
SGTC_2398 5228213 48.84 µM 0.308628580384054 0.362298926658605 no 1199 0.37880203875621 1937 80771 YMR134W ERG29
SGTC_2025 5147754 141 µM 0.307053787664492 0.362908150645035 no 1200 0.379401215855064 1858 315777 YLR208W SEC13
SGTC_3180 9109287 49.47 µM 0.307019955380951 0.362921242809549 no 1201 0.379414091546225 1777 18891271
SGTC_2730 imipramine 71.33 µM 0.305253244831722 0.363605133566599 no 1202 0.380086641365688 1865 3696 A tricyclic antidepressant.
SGTC_186 3455-3465 67.277 µM 0.301273783022287 0.365147166709322 no 1203 0.381602865427905 1791 755278
SGTC_1656 st012921 11 µM 0.298467689070118 0.366235836391407 no 1204 0.382673116644473 1865 6732821
SGTC_1243 0416-0003 5.65 µM 0.297317276226842 0.366682469666759 no 1205 0.383112146580442 1763 2141977
SGTC_3064 1327-0027 10 µM 0.296664956573759 0.366935804808769 no 1206 0.383361156889207 1789 16000455 YPR107C YTH1
SGTC_1668 st014914 51.6 µM 0.29618997005676 0.367120307250715 no 1207 0.383542504058419 1806 2839556
SGTC_654 1124-0271 80.9 µM 0.29605949507976 0.367170993962957 no 1208 0.383592323136208 1718 5403748
SGTC_314 1671-0008 2.74 µM 0.29575052162718 0.367291032710751 no 1209 0.383710305710186 1808 3913060
SGTC_1604 st002052 72.4 µM 0.295457006171695 0.367405077912878 no 1210 0.383822395581056 1803 6254834 YHR062C RPP1
SGTC_136 0097-0015 404.482 µM 0.294587026642996 0.367743176460939 no 1211 0.384154686924323 1910 4861337
SGTC_2703 st077852 53.4 µM 0.294238679148003 0.367878582864989 no 1212 0.38428776320844 1807 6281836
SGTC_222 nsc-310342 10.666 µM 0.29420674880901 0.367890995351714 no 1213 0.384299961971859 1898 432556
SGTC_816 0325-0417 81.3 µM 0.293957188237292 0.367988013394997 no 1214 0.384395308795652 1759 68101
SGTC_655 k060-0012 42 µM 0.293183891902723 0.368288690045512 no 1215 0.384690797894208 1766 5994525
SGTC_486 niguldipine 82 µM 0.292190687734211 0.368674990623904 no 1216 0.385070415617518 1838 1236 A calcium channel blocker.
SGTC_1973 st070275 50.2 µM 0.291542654236198 0.368927110804764 no 1217 0.385318163286261 1901 17118334
SGTC_1341 1486-1360 280 µM 0.291393645628709 0.368985091216239 no 1218 0.385375136925844 1771 3976547
SGTC_1667 st014849 34.6 µM 0.291295259860978 0.369023375520144 no 1219 0.385412756211228 1829 5348460
SGTC_3356 9151811 4.48 µM 0.290500819593088 0.369332559199903 no 1220 0.385716561928476 1763 1859254 YPR165W RHO1
SGTC_916 4466-0038 42 nM 0.289632813468197 0.369670470195564 no 1221 0.386048580474867 1964 5722064 YGL116W CDC20
SGTC_559 1550-0661 158 µM 0.289522047745122 0.369713598056842 no 1222 0.386090955166564 1837 5830875
SGTC_2977 9011197 71.43 µM 0.289418453556161 0.369753935085155 no 1223 0.386130587535847 1866 2704722
SGTC_1730 st033808 45.1 µM 0.288531553123103 0.37009933091036 no 1224 0.386469940543179 1786 1045166
SGTC_778 3456-2434 196 µM 0.287569868980889 0.370473969026557 no 1225 0.386838006034413 1948 5539063
SGTC_718 1130-0073 349 µM 0.287295579150298 0.370580845176552 no 1226 0.386943003687852 1860 6740020
SGTC_675 1309-0189 238 µM 0.284948367625114 0.371495836285534 no 1227 0.387841849654964 1784 4246530
SGTC_663 1486-0733 13.9 µM 0.284084465196427 0.371832786344705 no 1228 0.388172825856887 1810 722445 YPR165W RHO1
SGTC_155 k072-0202 43.6 µM 0.281307147316929 0.372916694819902 no 1229 0.389237414402209 1923 5857737
SGTC_2523 spermine 47.74 µM 0.280574240594779 0.373202895802354 no 1230 0.389518487859297 1949 1103 A DNA binding polyamine.
SGTC_807 1315-0151 48 µM 0.279891640161667 0.37346951505784 no 1231 0.389780320590524 1957 4011080
SGTC_163 TUB2.036 7.546 µM 0.279448446392452 0.373642656083838 no 1232 0.389950348206266 1897 15992207 YJR013W GPI14
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.278364024599362 0.374066411008488 no 1233 0.390366466380186 1838 88881 An O-methylated flavonoid and antioxidant.
SGTC_67 0335-0847 266 µM 0.276239583495095 0.374897010689345 no 1234 0.391182028167161 1994 4552207 YOR254C SEC63
SGTC_2918 7977171 22.06 µM 0.274431866871116 0.375604236976084 no 1235 0.391876378235329 1816 2236483
SGTC_2219 9098279 200 µM 0.273884126062092 0.375818610248469 no 1236 0.392086835444486 1927 902349
SGTC_2634 4'-methoxyflavone 100 µM 0.273867306660133 0.375825193586143 no 1237 0.39209329842513 1793 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1195 1502-0147 41.1 µM 0.272797220443645 0.376244113794595 no 1238 0.392504548161019 1806 817940
SGTC_674 0498-0004 451 µM 0.272671512442383 0.376293335880586 no 1239 0.392552867468234 1785 4231473
SGTC_3160 9100216 49.47 µM 0.272671215527289 0.376293452142714 no 1240 0.392552981597629 1933 17191039
SGTC_108 0509-0257 621.132 µM 0.271177790257869 0.376878369876887 no 1241 0.393127147000023 1917 536624
SGTC_2002 4023503 131 µM 0.269989428418291 0.377344007950059 no 1242 0.393584193300518 2016 4736863 YCR052W RSC6
SGTC_728 3030-5151 22.5 µM 0.269362076202912 0.377589896540878 no 1243 0.393825533384548 1852 3125388
SGTC_3139 9095020 49.47 µM 0.268668370458756 0.377861849941495 no 1244 0.394092446908022 1859 25236292
SGTC_727 3032-0951 202 µM 0.26795287121278 0.378142410475545 no 1245 0.394367797921813 1854 3652836
SGTC_1644 st010134 20.9 µM 0.267811339440527 0.378197915328987 no 1246 0.394422270928325 1957 3818134
SGTC_624 k048-0052 28 µM 0.267725029434157 0.3782317649645 no 1247 0.394455491094494 1845 6835531
SGTC_3061 glucosamine 200 µM 0.267450430477157 0.37833946523571 no 1248 0.394561187571515 1964 91431 and experimental redox chemotherapeutic
SGTC_2716 st080858 38.6235 µM 0.267127424244058 0.378466163390381 no 1249 0.394685526533173 1926 5296050
SGTC_2969 9091408 28.7 µM 0.266723420734633 0.378624650856298 no 1250 0.394841059923056 1722 4286311
SGTC_3138 9097216 49.47 µM 0.266234875489008 0.378816330663614 no 1251 0.395029162601958 2007 25237486
SGTC_2863 9028737 58.44 µM 0.266104001749645 0.378867683793229 no 1252 0.395079556566557 1965 6460917
SGTC_1178 0988-0033 191 µM 0.265031061401605 0.379288771991089 no 1253 0.395492766803925 1899 5392207
SGTC_3320 9137005 35.139 µM 0.264336240601779 0.379561539131799 no 1254 0.395760418555442 1818 4908713
SGTC_2575 plumbagin 510 nM 0.263011158913432 0.380081895086897 no 1255 0.396270989131456 1757 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.261774493350229 0.380567726200177 no 1256 0.396747652437595 1936 94937 An inhibitor of serotonin biosynthesis.
SGTC_824 1304-0008 100 µM 0.261347350156995 0.380735575656158 no 1257 0.396912327416427 1851 768245
SGTC_29 0299-0004 12.984 µM 0.259818559933235 0.381336510201285 no 1258 0.397501866864733 1926 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2251 lansoprazole 556 µM 0.259089089815978 0.381623350166431 no 1259 0.397783251264805 1771 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_3233 9132340 49.47 µM 0.258557928904023 0.381832252521992 no 1260 0.397988173724534 1814 17682950
SGTC_3181 9108277 49.47 µM 0.258100037932131 0.382012365880967 no 1261 0.39816485115266 1822 17097298
SGTC_2141 5621638 7.665 µM 0.256726593450686 0.38255276915229 no 1262 0.39869492040847 1961 2856238
SGTC_2400 5203494 178.7 µM 0.25356999840591 0.38379564655692 no 1263 0.399913888508729 1841 6777674
SGTC_1198 1612-1005 86.7 µM 0.253340902174468 0.383885897599993 no 1264 0.400002395696993 1948 6998509
SGTC_1408 3909-7976 48.8 µM 0.252938154676463 0.384044572750539 no 1265 0.400158002364294 1884 24152374
SGTC_1841 st054148 70 µM 0.251220813723562 0.384721391551568 no 1266 0.400821696719121 1819 675442
SGTC_2675 theaflavin digallate 100 µM 0.250794424544847 0.384889489731522 no 1267 0.400986526208447 1888 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2718 lomofungin 53.02 µM 0.250784460795345 0.384893418064164 no 1268 0.400990378111213 1961 5351222 A RNA synthesis inhibitor.
SGTC_1766 st045414 44.774 µM 0.249258787826162 0.385495072876546 no 1269 0.401580303962094 1868 253960
SGTC_1314 1222-0010 41.1 µM 0.247084360319071 0.386353042551604 no 1270 0.402421468604468 1886 3526027
SGTC_302 1094-0063 18.9 µM 0.246107132717934 0.386738811187286 no 1271 0.402799650877216 1860 5440289
SGTC_3287 9117173 37.0625 µM 0.246039930655505 0.386765343872153 no 1272 0.402825661091373 1972 2789709
SGTC_2583 asiatic acid 100 µM 0.245342801635171 0.387040615206477 no 1273 0.403095506659587 1893 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1382 3002-2117 298 µM 0.244668147276513 0.38730706620766 no 1274 0.403356696658114 1998 1497314
SGTC_247 mechlorethamine 29.705 µM 0.244597163945149 0.387335103770596 no 1275 0.403384180107375 1901 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1433 4060-0023 7.6 µM 0.243881833006477 0.387617683675468 no 1276 0.403661169792406 1939 3840627
SGTC_1048 3161-0300 24.5 µM 0.24385113497736 0.387629811768264 no 1277 0.403673057732992 1875 2165101
SGTC_1664 st014217 9.02 µM 0.243682678693662 0.387696366964276 no 1278 0.403738294719476 1991 3982782
SGTC_1711 st032263 62.8 µM 0.243257159000224 0.387864499733307 no 1279 0.403903094929024 1919 3958979
SGTC_1830 st055982 50.3 µM 0.240743332775664 0.388858199200113 no 1280 0.404877025893802 2004 455313 An antimicrobial agent.
SGTC_1764 st044502 93.5 µM 0.240730312493176 0.388863347934216 no 1281 0.40488207187786 1879 8407
SGTC_1948 st076329 66.6 µM 0.239491224279838 0.389353421566078 no 1282 0.405362350256967 1980 24208413
SGTC_831 k061-1017 217 µM 0.237951330115358 0.389962712667758 no 1283 0.405959421486193 1971 1240153
SGTC_587 k089-0003 57 µM 0.237933047067766 0.389969948362753 no 1284 0.405966511785065 1998 9659696
SGTC_2946 9065502 71.43 µM 0.237448757778521 0.390161624461095 no 1285 0.406154333916996 1947 16489101
SGTC_212 3807-4682 38.772 µM 0.237357465663494 0.390197759817206 no 1286 0.406189742199729 1975 3125501 YBL034C STU1
SGTC_1403 3909-7815 62.9 µM 0.235853436805468 0.390793222700067 no 1287 0.406773200509068 1892 6615483
SGTC_617 3770-0098 35 µM 0.235784217978514 0.390820633432057 no 1288 0.406800057578997 1885 5962639
SGTC_2274 7947094 46.08 µM 0.235647184370811 0.390874900492116 no 1289 0.406853228238314 2015 2971028
SGTC_1621 st003705 32.4 µM 0.234912186227919 0.391166005393606 no 1290 0.407138445483273 2017 24207032
SGTC_2420 aureobasidin a 50 nM 0.231366586270606 0.392571136997258 no 1291 0.408515010628012 2007 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1612 st002233 45.4 µM 0.230787663143697 0.392800699502773 no 1292 0.408739882961585 1993 1035021
SGTC_206 4546-0025 72.014 µM 0.230212293397068 0.39302888992522 no 1293 0.408963404819042 1900 6620745 YIL048W NEO1
SGTC_3216 9129716 49.47 µM 0.230003475232115 0.393111715863365 no 1294 0.409044534631516 1869 8056934
SGTC_189 3970-0742 2.116 µM 0.228423582471908 0.393738523352121 no 1295 0.4096584789256 2015 2891807
SGTC_3017 9080681 49.47 µM 0.228039575889444 0.393890915996138 no 1296 0.409807736922048 1863 16451914
SGTC_890 0929-0006 47.2 µM 0.227231284536221 0.394211738719458 no 1297 0.410121951171283 1840 1378169
SGTC_2968 9090663 33.37 µM 0.226230454008592 0.394609082528845 no 1298 0.410511092832734 1889 25236811
SGTC_2044 5102272 200 µM 0.225901920776138 0.394739538776187 no 1299 0.410638851937795 1913 592666
SGTC_1495 4469-0029 237 µM 0.225541498380185 0.394882671370736 no 1300 0.410779022920479 1874 793680
SGTC_3153 9100258 49.47 µM 0.223939670786291 0.39551896788585 no 1301 0.411402123346119 1851 25236848
SGTC_475 α-linolenic acid 10 µM 0.223873068249337 0.395545430561855 no 1302 0.411428036147403 2010 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1438 4092-1045 4 µM 0.223801574553171 0.395573837140629 no 1303 0.411455852363783 1918 1351342
SGTC_1574 spiramycin 23.7 µM 0.223558429031155 0.395670450262582 no 1304 0.411550456879805 1915 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_208 k072-0098 12.366 µM 0.222661156497618 0.396027034170305 no 1305 0.41189961751491 2014 5948901
SGTC_219 mitoxanthrone 164.414 µM 0.222153336884463 0.39622888468156 no 1306 0.412097259108531 1984 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1552 6-methylflavone 10.6 µM 0.220891854918654 0.396730424715237 no 1307 0.412588319808647 2032 689013
SGTC_793 0488-0545 106 µM 0.219907333502421 0.397121969541622 no 1308 0.412971662402034 1869 292548
SGTC_2844 9010103 25.97 µM 0.219394012669074 0.397326158740939 no 1309 0.41317156681219 1897 2480525
SGTC_1722 st034304 3.6505 µM 0.218978331891322 0.397491529219796 no 1310 0.413333463398518 1884 4036148 YLR033W RSC58
SGTC_2525 harmine 47.85 µM 0.218644434989393 0.397624376927046 no 1311 0.41346351801904 1982 5280953 A monoamine oxidase inhibitor
SGTC_1351 1496-0003 46.5 µM 0.21857007870918 0.39765396271004 no 1312 0.413492481479106 1999 3891978
SGTC_2142 5622915 118.518 µM 0.218361482882403 0.397736964501616 no 1313 0.413573736803729 1904 5322196
SGTC_1322 1348-1070 12 µM 0.21788958608174 0.397924752736572 no 1314 0.413757570661457 2007 6758089
SGTC_143 4032-1194 15.74 µM 0.217245600811278 0.398181060601675 no 1315 0.414008474430503 1878 1806963
SGTC_80 0159-0065 512.242 µM 0.21673722056599 0.398383428344071 no 1316 0.414206569784835 2034 1548079
SGTC_408 cantharidin 100 µM 0.215134120654033 0.399021743029411 no 1317 0.414831376119112 1937 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_403 arphamenine a 50 µM 0.215097642215519 0.399036270989958 no 1318 0.41484559606197 1942 5487158 An arginine aminopeptidase inhibitor.
SGTC_576 1073-0113 22.7 µM 0.214299026982201 0.399354363768509 no 1319 0.415156938384848 2048 5439563
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.213510256945926 0.399668600753478 no 1320 0.415464494838722 1871 2374 Ca(2+)-ATPase inhibitor.
SGTC_58 0957-0393 9 µM 0.211793327357013 0.400352830382814 no 1321 0.416134137218945 1906 6997992
SGTC_2242 6630449 61.2675 µM 0.210726946357692 0.400777957984348 no 1322 0.41655017328341 1954 691249 YDR170C SEC7
SGTC_424 splitomicin 100 mM 0.210544883589072 0.400850551597608 no 1323 0.416621212298277 1837 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3198 9112019 49.47 µM 0.208269704958142 0.40175801811705 no 1324 0.417509192458377 1939 45595555
SGTC_354 2783-3500 4.88 µM 0.20697764784806 0.40227359790514 no 1325 0.418013657473099 1858 6740761
SGTC_757 1066-0008 322 µM 0.206604460278201 0.402422545592221 no 1326 0.41815938831224 2018 6842497
SGTC_2752 diclazuril 33.15 µM 0.20564273656402 0.402806456753452 no 1327 0.418534995983448 2063 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1701 st028638 40.4 µM 0.204974071184269 0.403073437016859 no 1328 0.418796191552606 2020 3490878
SGTC_2874 9043904 71.43 µM 0.204314457799869 0.40333684733994 no 1329 0.41905388628951 1906 4463428
SGTC_1437 4092-1038 11.6 µM 0.203159951138863 0.403797994084112 no 1330 0.419505007195451 1956 3977136
SGTC_2174 5790901 200 µM 0.202733647441988 0.403968307209955 no 1331 0.419671611197875 1935 786020
SGTC_1972 st070201 17.4 µM 0.202105966940752 0.404219105765747 no 1332 0.419916941590375 2064 2829099
SGTC_682 0kpi-0099 17 µM 0.201654889491583 0.404399364412048 no 1333 0.420093265492637 1906 1714895 YML126C ERG13
SGTC_1010 4112-3296 15.2 µM 0.198813533279166 0.405535286451418 no 1334 0.421204304646415 2110 704384
SGTC_323 4013-0906 34.3 µM 0.197288423313265 0.406145326341781 no 1335 0.4218009190854 2073 2910086
SGTC_1999 st074831 12.5 µM 0.195980601897302 0.406668632992384 no 1336 0.422312674509225 1932 17112523
SGTC_2776 terbinafine 19.92 µM 0.195503678656483 0.406859508762365 no 1337 0.422499329048012 2055 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_711 k292-0785 179 µM 0.195450147030228 0.406880934745888 no 1338 0.422520280930093 1990 4146315
SGTC_1346 1488-2224 62.4 µM 0.195219681853308 0.406973181400334 no 1339 0.42261048579633 2077 3722427
SGTC_903 1134-0042 114 µM 0.194741240382555 0.407164700231856 no 1340 0.422797762393401 1925 701009
SGTC_801 0866-0028 10.1 µM 0.193474279663608 0.407671968300389 no 1341 0.423293773673114 1930 6849771
SGTC_971 1315-0384 26.7 µM 0.192045793766896 0.408244093791097 no 1342 0.423853167372691 1895 6769120
SGTC_1806 st050005 60.3 µM 0.190390999858809 0.408907102861959 no 1343 0.42450137488002 1915 5194765
SGTC_2923 7992654 58.14 µM 0.19035838447696 0.408920173154212 no 1344 0.424514152870767 1939 2985126
SGTC_397 arbidol 50 µM 0.190143408292126 0.409006325270904 no 1345 0.424598377805715 2054 131410 A RNA synthesis inhibitor.
SGTC_1836 st055642 81 µM 0.188728052117035 0.409573641521986 no 1346 0.425152982130197 1877 8571
SGTC_2565 isoliquiritigenin 100 µM 0.188232450086947 0.409772338177602 no 1347 0.425347217816659 1809 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1037 k284-1091 78.7 µM 0.18772997145167 0.409973815458854 no 1348 0.425544167072504 1967 3334711
SGTC_1423 4048-0112 5.59 µM 0.187261799165849 0.410161558423458 no 1349 0.425727686487327 2081 X1423
SGTC_1359 1582-0056 520 nM 0.186335412738488 0.410533111663368 no 1350 0.426090869192783 2030 3661189
SGTC_794 k038-0031 316 µM 0.185201560067505 0.410987984326136 no 1351 0.426535472751533 2020 6624242
SGTC_2014 4013930 200 µM 0.184936698554842 0.411094257255145 no 1352 0.426639343078837 2128 64556
SGTC_181 1447-1644 8.07 µM 0.184780382094559 0.411156980672501 no 1353 0.426700647849811 2078 534600
SGTC_2595 hexamethylquercetagetin 100 µM 0.184735895172858 0.41117483187423 no 1354 0.426718095220029 1983 386331
SGTC_1223 0764-0573 147 µM 0.184275951051162 0.411359403750657 no 1355 0.426898489562837 1996 1609797
SGTC_2545 solidagenone 89.61 µM 0.182909562157373 0.411907840194688 no 1356 0.427434489978417 2020 6708572 An anti ulcer agent
SGTC_3196 9111891 49.47 µM 0.18279830296707 0.411952504615638 no 1357 0.427478140106346 2078 18891510
SGTC_878 0828-0289 13.7 µM 0.180981051734721 0.412682191698329 no 1358 0.42819122446813 1942 745350 YLR208W SEC13
SGTC_93 0109-0045 59.227 µM 0.180931106521674 0.412702250643469 no 1359 0.428210826154092 2106 88733
SGTC_2670 beta-carotene 100 µM 0.180112458752041 0.413031067574533 no 1360 0.428532140945251 2069 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_97 0535-0701 19.132 µM 0.178346976239464 0.413740396256155 no 1361 0.429225244214328 1994 2832013 YGL099W LSG1
SGTC_1458 k015-0034 6.33 µM 0.176763946541942 0.414376659253079 no 1362 0.429846904770856 1912 3598957
SGTC_905 2-aminofluorene 215 µM 0.175329612995999 0.414953351327745 no 1363 0.430410322172497 2086 1539 An established DNA mutagen. YPR165W RHO1
SGTC_157 1348-1695 65.819 µM 0.17444589781694 0.415308751618242 no 1364 0.430757523007186 2053 5380510
SGTC_142 0335-0849 62.6745 µM 0.174411011020198 0.415322783329252 no 1365 0.430771230700962 2037 3889043 YPR107C YTH1
SGTC_1915 st067105 30.6 µM 0.17381385278271 0.415562981234472 no 1366 0.431005878582872 2054 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_578 3460-0051 92 µM 0.173580040778467 0.41565703719201 no 1367 0.431097759516735 2110 2876744
SGTC_1420 4'-methoxyflavone 42 µM 0.172791699003405 0.415974200378666 no 1368 0.431407581067623 2101 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_167 3672-0051 66.205 µM 0.172585998646975 0.416056966112178 no 1369 0.431488429102121 2028 3237971
SGTC_522 1273-0010 11.6 µM 0.172188910116658 0.416216749446972 no 1370 0.431644508056545 2025 5705015
SGTC_2744 captopril 92.04 µM 0.170826000669824 0.416765271913752 no 1371 0.43218029199552 2116 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_83 0170-0301 39.027 µM 0.170034307714361 0.417083974601147 no 1372 0.432491577918669 2118 3089716
SGTC_1379 2144-0755 36.5 µM 0.169964241935327 0.417112182800166 no 1373 0.432519129118651 2113 5392327
SGTC_2131 toluylene red 5.2905 µM 0.168891402308165 0.417544156892158 no 1374 0.432941031007495 1952 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1794 st048918 76.9 µM 0.168719600805667 0.417613341259656 no 1375 0.433008600296291 2111 672303
SGTC_1812 st052057 4.327 µM 0.168460527558252 0.417717674731149 no 1376 0.433110497142458 2040 3645418
SGTC_1554 st069299 38.7 µM 0.167443755250394 0.41812720319361 no 1377 0.433510449706003 2042 24207999
SGTC_1497 4476-2978 41.3 µM 0.166843503899008 0.418369009955007 no 1378 0.433746593624245 2067 1528379
SGTC_691 1548-0686 185 µM 0.166420488655009 0.418539437016859 no 1379 0.433913025582151 1977 46495133
SGTC_2268 7933382 153.85 µM 0.166318976087955 0.418580337319479 no 1380 0.433952966632532 2136 935025 YOR257W CDC31
SGTC_581 0958-0271 211 µM 0.165861945475856 0.418764489853426 no 1381 0.434132797864574 1990 4591145
SGTC_2798 7813637 45.45 µM 0.165510860798538 0.418905965408959 no 1382 0.43427095102253 2037 956368
SGTC_288 1315-0019 35.1 µM 0.163089039838493 0.419882164195872 no 1383 0.435224164601883 2035 6811474
SGTC_3052 9092717 49.47 µM 0.162360007073058 0.420176122941214 no 1384 0.435511181326128 2007 25237534
SGTC_1924 st058459 75.1 µM 0.162118451655194 0.420273532135339 no 1385 0.435606288043415 2081 688683
SGTC_227 fluconazole 33.516 µM 0.162036401481026 0.420306620649244 no 1386 0.435638594201365 1980 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_729 4092-0585 94.1 µM 0.162026037958145 0.420310800004886 no 1387 0.435642674730354 1962 2169061
SGTC_759 3486-0358 89.3 µM 0.159410010230253 0.421366066240432 no 1388 0.436672926367448 2157 875103
SGTC_2275 7947463 200 µM 0.157443711319627 0.422159614058603 no 1389 0.437447583176136 2135 1225414
SGTC_1839 st053978 48 µM 0.15491900772711 0.423178982790362 no 1390 0.43844258427831 2140 3788398
SGTC_684 1140-0066 328 µM 0.154764013765442 0.423241579640094 no 1391 0.438503681089713 2020 6813534
SGTC_2388 9080168 200 µM 0.154638212882592 0.423292387811495 no 1392 0.438553271407613 1956 15943073
SGTC_2109 5483026 200 µM 0.153187094054794 0.4238785543628 no 1393 0.439125367500566 2025 759335
SGTC_547 1120-0019 610 nM 0.152514583273667 0.424150266321045 no 1394 0.439390544599785 2025 3676939
SGTC_1017 4239-0030 168 µM 0.151585304189538 0.424525778704342 no 1395 0.439757012504883 1946 1149593
SGTC_66 0109-0187 42.4 µM 0.149945113472167 0.425188730348618 no 1396 0.440403959319651 2132 759417
SGTC_346 4513-0042 7.16 µM 0.148825673402262 0.42564132046146 no 1397 0.440845595896505 2049 2827372
SGTC_263 alizarin 107.927 µM 0.148370021838984 0.425825568682335 no 1398 0.441025378650547 2127 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1714 st033236 13.627 µM 0.148358969914536 0.425830037863 no 1399 0.441029739470168 2103 2916566
SGTC_809 3998-0021 90 µM 0.148327408859662 0.425842800584692 no 1400 0.441042192731408 2161 715485
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.147370602819218 0.426229752516382 no 1401 0.441419753850918 2118 16486 A toxic proline analog.
SGTC_1434 4073-0095 163 µM 0.147160059613599 0.426314910042697 no 1402 0.441502842559114 2131 24133745
SGTC_2303 7774051 200 µM 0.146143843632275 0.426725982894534 no 1403 0.441903917868177 2119 2953184
SGTC_2824 7998404 51.95 µM 0.145747243871829 0.426886434380802 no 1404 0.44206046216576 2063 837851
SGTC_2902 5787006 60.46 µM 0.145642912149059 0.426928645645716 no 1405 0.442101645077368 2036 591003
SGTC_985 1493-0307 8.71 µM 0.145602234350061 0.426945103583546 no 1406 0.442117702014307 2160 3278274
SGTC_1474 0330-0125 5.35 µM 0.144429218641476 0.427419751696469 no 1407 0.442580772773746 2130 X1474
SGTC_803 4488-1585 147 µM 0.143216718424991 0.427910487226211 no 1408 0.443059513268033 2128 747204
SGTC_3229 9132204 49.47 µM 0.142844772504633 0.428061047384598 no 1409 0.443206388142822 2069 17682924
SGTC_435 c-PAF 6.7 µM 0.142350974590068 0.428260948246458 no 1410 0.443401392272025 2162 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_43 0570-0105 72.5 µM 0.142271199533867 0.428293244770305 no 1411 0.443432897267521 2086 1114046 YDL195W SEC31
SGTC_1220 1838-0075 193 µM 0.141936494505716 0.428428753623056 no 1412 0.443565083838547 2089 5529645
SGTC_2489 cantharidin 73.42 µM 0.141123300029287 0.428758019092305 no 1413 0.443886268546949 2152 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_232 clozapine 119 µM 0.140922496405851 0.428839332869937 no 1414 0.443965584966941 2121 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.140751667116367 0.428908511165209 no 1415 0.444033063443049 2157 5355888
SGTC_374 0880-0231 82.3 µM 0.140091110010875 0.429176028063842 no 1416 0.444294002255292 2136 6833587
SGTC_1982 st072467 71.9 µM 0.138600777037179 0.429779712543128 no 1417 0.44488281462546 2014 3163533
SGTC_2103 5378138 10 µM 0.138582232724253 0.429787225266816 no 1418 0.44489014202604 2141 244142
SGTC_2870 9038528 12.99 µM 0.138572244082042 0.429791271903896 no 1419 0.444894088838614 2073 6463316
SGTC_817 1391-0715 46 µM 0.138376347397042 0.429870635811303 no 1420 0.444971494606851 2028 1353946
SGTC_1139 k015-0024 46.9 µM 0.138149976698533 0.429962349229085 no 1421 0.445060944358016 2174 2766652
SGTC_1422 4031-0024 15.5 µM 0.13638047995112 0.430679385446013 no 1422 0.445760252116284 2162 782427
SGTC_1953 st076800 12.1 µM 0.135835114423061 0.430900424888972 no 1423 0.445975815513293 1942 297591
SGTC_1414 3917-0015 5.4 µM 0.135128299358402 0.431186932855205 no 1424 0.446255217862274 2138 6618702
SGTC_1409 3909-8004 61.9 µM 0.132629271199831 0.432200204981117 no 1425 0.447243290925235 2076 2119279
SGTC_2341 7987486 176.74 µM 0.131959144170805 0.43247199515451 no 1426 0.447508303654472 2174 1258686
SGTC_386 1509-0011 3.07 µM 0.131818727443885 0.432528949435457 no 1427 0.447563836726874 2106 3107280
SGTC_1676 st018489 23.4 µM 0.13135135703615 0.43271852914722 no 1428 0.447748683319823 2013 3696235
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.130611436596353 0.433018695129254 no 1429 0.448041347569916 2160 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1285 0929-0069 65.5 µM 0.128642167327251 0.433817762993072 no 1430 0.448820399399829 2063 1206237
SGTC_2437 5741531 144.16 µM 0.128605323888339 0.433832715496381 no 1431 0.448834976721153 2178 2262990
SGTC_1530 rhein 70.4 µM 0.126649490090095 0.434626604475019 no 1432 0.449608912432031 2176 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1791 st048313 56.1 µM 0.125888551928474 0.434935546940013 no 1433 0.449910072408068 2196 1204976
SGTC_98 0074-0023 107.663 µM 0.123513689209527 0.435900000747399 no 1434 0.450850167435309 2024 3563821
SGTC_1959 st077091 55.8 µM 0.122177877842145 0.436442654083249 no 1435 0.45137907305452 2157 821356 YKL052C ASK1
SGTC_365 0121-0052 13.6 µM 0.121106652722419 0.436877909716284 no 1436 0.451803279927206 2138 3101739
SGTC_2362 9071156 126 µM 0.120220240897915 0.43723813060421 no 1437 0.452154342071357 2164 653133
SGTC_2095 5432005 200 µM 0.120197437127295 0.437247398310206 no 1438 0.452163373967108 2124 783734
SGTC_2112 5488546 200 µM 0.1195818084188 0.437497609660522 no 1439 0.4524072155408 2155 600757
SGTC_2662 daunorubicin 22.37 µM 0.119250390624384 0.437632318891676 no 1440 0.452538492746052 2166 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1468 k284-1086 134 µM 0.11858708144679 0.43790195154849 no 1441 0.452801250318294 2079 15996457
SGTC_2452 5863136 48.41 µM 0.118332064997739 0.438005622445417 no 1442 0.452902275840299 2170 2184096
SGTC_540 1187-0821 17.3 µM 0.118198596368752 0.438059882651853 no 1443 0.452955151048935 2009 847520
SGTC_995 3931-2021 34.6 µM 0.118120944794849 0.438091451583 no 1444 0.452985914041254 2100 730143
SGTC_643 k048-0106 28.4 µM 0.117645327492128 0.438284820450142 no 1445 0.453174344079026 2148 6763920
SGTC_958 1222-0007 33 µM 0.117618261111817 0.438295825109218 no 1446 0.453185067553623 2155 7312461
SGTC_1886 st057356 49.9 µM 0.11732036698661 0.438416946165045 no 1447 0.453303092980365 2009 24207747
SGTC_2680 butyl paraben 22.24 µM 0.117093293181847 0.438509276194337 no 1448 0.453393062220886 2205 7184 An antifungal and steroid mimetic.
SGTC_1867 st057372 64 µM 0.116215567330705 0.438866197987306 no 1449 0.453740849702956 2192 688837
SGTC_1299 1079-1439 3.74 µM 0.115511587581696 0.439152502945117 no 1450 0.454019818197388 2111 323161
SGTC_35 0133-0054 64.071 µM 0.115039716855154 0.439344428182812 no 1451 0.454206820753026 2108 99677
SGTC_501 nsc-95397 161 µM 0.114636441325266 0.439508464815588 no 1452 0.454366647051861 2167 262093
SGTC_1697 st025554 27.742 µM 0.113994515078947 0.439769596593143 no 1453 0.454621070717268 2189 1269519
SGTC_2724 maprotiline 69.64 µM 0.113003271894803 0.440172879860205 no 1454 0.455013980617417 2178 4011 A tricyclic antidepressant.
SGTC_994 3910-0338 138 µM 0.112244330322069 0.4404816941401 no 1455 0.455314840357987 2170 3479481
SGTC_3030 9087619 49.47 µM 0.11206311635883 0.440555435690863 no 1456 0.455386681023449 2160 25236973
SGTC_3246 9135460 32.98 µM 0.11142303196329 0.440815922257952 no 1457 0.455640448456156 2174 41446951
SGTC_3331 9141060 1.957 µM 0.111216712953091 0.440899890603405 no 1458 0.45572224941556 2067 4906567 YPR165W RHO1
SGTC_1225 1216-0074 20.6 µM 0.110497019735388 0.44119281433912 no 1459 0.456007606652349 2095 4241466
SGTC_3044 9093193 49.47 µM 0.10686923850926 0.44266985123051 no 1460 0.457446358755084 2082 25236277
SGTC_1291 0993-0025 5.79 µM 0.106095303323369 0.442985059776528 no 1461 0.457753368759901 2187 4353356
SGTC_159 3970-0959 50 µM 0.105939118289613 0.443048675244817 no 1462 0.457815328390865 2180 6615653
SGTC_743 1275-0778 158 µM 0.105928723627331 0.443052909129676 no 1463 0.457819452058216 2196 2849257 YMR203W TOM40
SGTC_710 3448-4187 58 µM 0.105397474586771 0.443269302610996 no 1464 0.458030209946159 2178 3946412
SGTC_45 0kpi-0036 14.9 µM 0.104624860379141 0.443584041460335 no 1465 0.45833674361814 2143 2795021
SGTC_3072 9116419 49.47 µM 0.103440064731109 0.444066759201516 no 1466 0.458806857807879 2126 17170162
SGTC_1888 azatryptophan 97.5 µM 0.103248667325074 0.444144747478155 no 1467 0.458882807666125 2106 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_944 3370-0224 231 µM 0.10302276145812 0.444236799623548 no 1468 0.458972453019816 2130 4580514
SGTC_2856 9022925 19.48 µM 0.100104444779451 0.445426224281317 no 1469 0.460130703318284 2152 4944862
SGTC_1940 st075990 51.1 µM 0.0981698715582134 0.44621497400848 no 1470 0.46089870294566 2158 1084979
SGTC_351 caspofungin 25 nM 0.0961937105701388 0.44702089935737 no 1471 0.461683362944958 2153 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1176 0848-0131 83.3 µM 0.0956076414191732 0.447259954488483 no 1472 0.461916098015526 2245 6769040
SGTC_1008 4106-0037 6 µM 0.0953600714311381 0.447360943002718 no 1473 0.462014414941851 2233 2905394
SGTC_2988 9073640 71.4286 µM 0.0950932656685971 0.447469781976514 no 1474 0.46212037352759 2184 9102229
SGTC_2224 6650123 117.647 µM 0.0949316638023342 0.447535706694458 no 1475 0.462184553003915 2211 2908370
SGTC_921 1561-0023 372 µM 0.0940512416507408 0.447894896163625 no 1476 0.462534226072303 2260 24050882
SGTC_1925 st057770 10.1 µM 0.0933752471252828 0.448170713462277 no 1477 0.462802727260543 2016 5989122
SGTC_1187 1391-0724 117 µM 0.0930568186559023 0.448300646400084 no 1478 0.462929211120666 2135 6997986
SGTC_1646 st011709 75.6 µM 0.0929977216609819 0.448324761205569 no 1479 0.462952685615508 2250 5757843
SGTC_1704 st028805 70.8 µM 0.0923134856668347 0.44860398078832 no 1480 0.463224487054447 2127 2876101
SGTC_2061 5245884 80.95 µM 0.0922814844909996 0.448617040291487 no 1481 0.46323719941384 2215 573863
SGTC_1740 st038286 13.222 µM 0.09204662971462 0.448712884931812 no 1482 0.46333049583121 2190 716786
SGTC_1921 5740136 50 µM 0.0919009554114358 0.448772336371321 no 1483 0.463388366183682 2240 1774243
SGTC_2741 miltefosine 3.04 µM 0.0912003258376345 0.449058287795115 no 1484 0.463666708026466 2194 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1629 st005085 44.9 µM 0.0911329799517851 0.449085775401983 no 1485 0.463693463728269 2167 24207091
SGTC_3034 9090421 49.47 µM 0.0907342419321288 0.449248527597797 no 1486 0.46385188085682 2239 17173761
SGTC_704 1310-0270 142 µM 0.0892788581903941 0.449842641280031 no 1487 0.46443014784228 2167 5718033
SGTC_917 harmaline 728.087 nM 0.0881347366564694 0.45030977116904 no 1488 0.464884793966315 2199 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1370 2001-0092 44.6 µM 0.0880750225049666 0.450334153573744 no 1489 0.464908524184565 2218 790957
SGTC_291 SEC14.278 35.5 µM 0.0880410717034003 0.450348016404493 no 1490 0.464922016183265 2239 1068044
SGTC_1463 k081-0032 34.1 µM 0.0872886349349723 0.450655267778976 no 1491 0.465221043773617 2202 977755
SGTC_2684 capsaicin 100 µM 0.0837406224787503 0.452104464984204 no 1492 0.466631329244431 2204 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3308 9128332 17.569 µM 0.0823820813029148 0.452659535609427 no 1493 0.46717144232955 2246 17332805 YDL196W YDL196W
SGTC_3 0833-0587 95.581 µM 0.0823599787151837 0.452668567017945 no 1494 0.467180230123145 2181 5382644
SGTC_1392 3455-1037 33.9 µM 0.0822151249895496 0.452727756764385 no 1495 0.467237823080371 2232 981132
SGTC_874 0599-0792 117 µM 0.081295200527231 0.453103678330466 no 1496 0.467603595391454 2262 765305
SGTC_3218 9131285 49.47 µM 0.0812575965030149 0.453119045883926 no 1497 0.467618547758407 2240 17156417
SGTC_1969 st069479 40.1 µM 0.0810638868505045 0.453198209891352 no 1498 0.467695572626633 2253 3895485
SGTC_3171 9103192 49.47 µM 0.0807603949442837 0.453322242738592 no 1499 0.467816252699455 2266 13018434
SGTC_3265 9137266 49.47 µM 0.0782527152771351 0.454347269079515 no 1500 0.46881351490454 2292 17224265
SGTC_2596 sinensetin 100 µM 0.077084113277795 0.454825045164907 no 1501 0.469278315580553 2199 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2742 clothiapine 36.27 µM 0.0769173460774643 0.454893232303531 no 1502 0.469344649126371 2270 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1055 3448-0672 86 µM 0.0767937933055564 0.45494375094822 no 1503 0.46939379419186 2205 748378
SGTC_2939 9044578 71.43 µM 0.0751681466109106 0.455608518029817 no 1504 0.470040463976477 2259 2653634
SGTC_973 1325-0077 65.9 µM 0.0750557802303607 0.455654472032173 no 1505 0.470085165400124 2225 2835149
SGTC_3283 9109332 35.8195 µM 0.074657122512441 0.455817514171504 no 1506 0.470243761848437 2284 17027281
SGTC_2959 9079155 11 µM 0.0744486866034571 0.455902762785973 no 1507 0.47032668497563 2205 16189457
SGTC_1914 st062367 72.6 µM 0.0744371384108374 0.455907485963493 no 1508 0.47033127929001 2213 978205
SGTC_2055 5235184 200 µM 0.074137844261131 0.456029898580191 no 1509 0.470450351368992 2228 2836034
SGTC_1258 0671-0043 57.1 µM 0.0734433990407633 0.456313945771639 no 1510 0.470726641690285 2196 4298767
SGTC_814 3342-0569 96 µM 0.0725973114723274 0.456660049011181 no 1511 0.471063283105494 2276 4346283
SGTC_387 norethindrone acetate 66.7 µM 0.072400604053467 0.456740519486599 no 1512 0.471141552046449 2192 541197
SGTC_2778 tioconazole 65.09 nM 0.0723340386825482 0.45676775092572 no 1513 0.471168038341681 2271 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2250 alverine citrate 130 µM 0.0720708205844474 0.456875433641376 no 1514 0.471272773810572 2247 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_3062 9077494 49.47 µM 0.0717560189759839 0.457004223366391 no 1515 0.471398037160272 2228 16459633
SGTC_380 3970-0968 6 µM 0.0714315591717717 0.457136969119743 no 1516 0.471527146583344 2244 2891601
SGTC_2807 7945238 51.95 µM 0.06973392015721 0.457831599264665 no 1517 0.472202721553227 2234 17148797
SGTC_523 1934-0222 13.7 µM 0.0696324084072924 0.457873139360107 no 1518 0.472243120679151 2263 1361595
SGTC_278 4092-0821 23.9 µM 0.0689067135788213 0.458170117693772 no 1519 0.472531937280399 2234 877900
SGTC_1516 st013856 110 µM 0.0684563421572493 0.458354436334443 no 1520 0.472711186209628 2212 5281404 A mutagen and neurotoxin.
SGTC_2746 daunorubicin 9.88 µM 0.0667975991061314 0.459033369088435 no 1521 0.473371417389028 2275 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2290 7904846 200 µM 0.0665889462456337 0.459118780367056 no 1522 0.473454472916116 2217 2962154
SGTC_845 0330-0138 4.51 µM 0.0630134509690168 0.460582686131558 no 1523 0.474877896641928 2297 9039800
SGTC_1475 4092-1048 11.7 µM 0.0617134232247979 0.461115086641398 no 1524 0.475395525079265 2192 2881759
SGTC_1144 3486-0183 12.5 µM 0.0601334106822588 0.461762243103618 no 1525 0.476024690112394 2213 6744069
SGTC_3326 9140064 16.379 µM 0.0594314825344244 0.462049778050386 no 1526 0.476304218966266 2285 1868434
SGTC_1369 1866-0067 208 µM 0.0589574106385482 0.462243986134508 no 1527 0.476493015228394 2280 3531355
SGTC_2052 5265182 7.135 µM 0.0582347100637544 0.462540064639276 no 1528 0.476780836496202 2288 1239884
SGTC_2496 diffractaic acid 79.83 µM 0.0571391952170682 0.462988918527576 no 1529 0.477217157070826 2306 94870 An apoptosis inducer which activates caspases.
SGTC_2249 haloperidol 116.36 µM 0.0567264295005712 0.463158048979453 no 1530 0.477381560106357 2296 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2071 5230951 39.92 µM 0.0561181441383204 0.463407305593934 no 1531 0.477623844891375 2294 1799272
SGTC_1296 1068-0102 11.9 µM 0.0557307504483536 0.46356605509567 no 1532 0.477778151123982 2289 767053
SGTC_1105 epirubicin 18.1 µM 0.0555702345973166 0.463631834356264 no 1533 0.477842088600415 2297 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2325 6158266 200 µM 0.0555501309863917 0.46364007286919 no 1534 0.477850096411466 2250 3623240
SGTC_1975 st070967 30.8 µM 0.0554882436685352 0.46366543455359 no 1535 0.47787474785732 2315 261391
SGTC_2774 tamoxifen 10.92 µM 0.0548660068315056 0.463920438027711 no 1536 0.478122606843499 2298 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_545 4218-0007 221 µM 0.0545920359611295 0.464032720759926 no 1537 0.478231741840338 2251 2840508
SGTC_3116 9124943 49.47 µM 0.0529180348813844 0.464718846161149 no 1538 0.478898607385756 2278 41905195 YPL160W CDC60
SGTC_594 1487-1584 10.8 µM 0.0521117091490736 0.46504937369701 no 1539 0.479219841546249 2290 5013332
SGTC_2080 5212524 12.4 µM 0.0518723613180785 0.465147491364174 no 1540 0.479315198545219 2334 260183
SGTC_2795 7780010 54.55 µM 0.05173777014375 0.465202666273717 no 1541 0.479368820652325 2264 953673
SGTC_1467 k284-1082 293 µM 0.0515656274483615 0.465273236197061 no 1542 0.479437404103821 2326 3334705
SGTC_1675 st018485 24.5 µM 0.0507349663335793 0.465613781154388 no 1543 0.479768356705987 2187 3323024
SGTC_2576 guaiol 23.12 µM 0.0499728441462825 0.465926249462567 no 1544 0.480072014253618 2313 227829
SGTC_310 1273-0058 1.06 µM 0.0489563585204724 0.466343038843787 no 1545 0.480477037531845 2299 2734232
SGTC_1169 aniline yellow 25.8 µM 0.0487515944970727 0.46642700267367 no 1546 0.480558629132236 2295 6051 A DNA damaging agent.
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.0484942543982802 0.466532527529635 no 1547 0.480661171691148 2303 279621
SGTC_2725 haloperidol 53.21 µM 0.0473822827431191 0.466988529471551 no 1548 0.481104274740978 2318 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_61 0978-8327 98.565 µM 0.0471512836018694 0.467083264011715 no 1549 0.481196327178078 2329 6150059 YHR072W ERG7
SGTC_364 0083-0097 67.7 µM 0.0460300603598473 0.467543112755709 no 1550 0.481643145296475 2265 5207356
SGTC_722 3534-0461 190 µM 0.0449779807077174 0.46797464295508 no 1551 0.482062430019153 2290 658262
SGTC_3280 9140961 49.47 µM 0.043033151231263 0.468772449951285 no 1552 0.482837553730392 2304 4901226
SGTC_1168 k815-0004 80.5 µM 0.0428286830417131 0.468856334133246 no 1553 0.482919049600406 2318 642433
SGTC_2524 avocatin b 10.57 µM 0.0413041562915375 0.469481822820708 no 1554 0.483526709829128 2311 6710748
SGTC_1780 st038448 24.544 µM 0.0412559412567665 0.469501605907121 no 1555 0.483545928463385 2292 728868 YDL195W SEC31
SGTC_1732 st034308 51.822 µM 0.0393033764076002 0.4703028245231 no 1556 0.484324257357016 2322 830119
SGTC_1978 st071761 42 µM 0.0392379599003564 0.470329669738211 no 1557 0.484350334651821 2182 5147680
SGTC_3146 9095609 49.47 µM 0.0389568729852516 0.470445021952893 no 1558 0.484462386431997 2320 17173999
SGTC_568 1193-0097 7.48 µM 0.0383716631542229 0.470685187822632 no 1559 0.484695676932015 2336 3646150
SGTC_638 3970-0837 4.09 µM 0.037427025283067 0.471072882812815 no 1560 0.485072262351183 2309 4118451 YLR208W SEC13
SGTC_2739 tacrine 100.86 µM 0.0366002669488055 0.471412220604431 no 1561 0.485401865339971 2298 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1227 3909-8010 46.6 µM 0.0358743258731957 0.47171019570413 no 1562 0.485691283835624 2291 15982272
SGTC_1167 k781-0610 148 µM 0.0358541579814943 0.471718474191777 no 1563 0.485699324487548 2301 4525169
SGTC_1347 1493-0251 600 nM 0.035390644946549 0.471908739726803 no 1564 0.485884122145846 2344 3986378
SGTC_345 1362-0200 395 µM 0.0351408552423355 0.472011277523173 no 1565 0.485983711872015 2304 1419823
SGTC_2442 5158906 48.48 µM 0.0349475879841539 0.472090614327224 no 1566 0.486060767022453 2322 1893835
SGTC_3210 9128157 49.47 µM 0.0347776243784859 0.47216038582549 no 1567 0.486128531497771 2185 17590849
SGTC_3228 9131799 49.47 µM 0.0334621718291719 0.47270041895883 no 1568 0.486653015717163 2277 17015818
SGTC_3285 9112818 20.8695 µM 0.0329737511572514 0.472900943273941 no 1569 0.48684775989866 2352 17017947 YPR165W RHO1
SGTC_690 glyoxal 20.3 µM 0.0311648284230831 0.473643667807186 no 1570 0.487569044566864 2327 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1698 5-fluorocytosine 1.055 µM 0.0309648297862727 0.473725790803488 no 1571 0.487648793989654 2351 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3252 9135871 49.47 µM 0.030283879177026 0.474005409583278 no 1572 0.487920326614862 2339 17682838
SGTC_60 0986-0278 202 µM 0.0291222412771396 0.474482442491205 no 1573 0.488383548672655 2298 3110598
SGTC_1085 doxorubicin 7.67 µM 0.0291098268178667 0.474487540755091 no 1574 0.488388499226503 2359 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2069 5228469 200 µM 0.0281456556025605 0.474883511035699 no 1575 0.488772990288305 2317 2835210
SGTC_1781 st038725 66.3 µM 0.0271768653345317 0.475281403278899 no 1576 0.489159333839202 2330 4270275 YIL048W NEO1
SGTC_3014 9081533 49.47 µM 0.0265566245068048 0.47553615560956 no 1577 0.489406684837645 2356 21367265
SGTC_2008 4012253 172 µM 0.0263194186356793 0.475633586138345 no 1578 0.489501283222128 2344 603940
SGTC_770 0389-1121 67.2 µM 0.0255324018350181 0.475956857778344 no 1579 0.489815151989585 2351 6753108
SGTC_1440 4100-1550 40 µM 0.0252253761595607 0.476082974628832 no 1580 0.489937598072835 2346 742806
SGTC_2406 ethylparaben 405.7 µM 0.0246837625113473 0.476305458948581 no 1581 0.490153603387087 2304 8434 A possible steroid mimic.
SGTC_592 k241-0073 46.5 µM 0.0233316767327933 0.476860901494576 no 1582 0.49069285210387 2370 4230158
SGTC_843 0310-0051 143 µM 0.0232599477287825 0.476890369337552 no 1583 0.490721460072542 2343 2065037
SGTC_962 1254-0300 21.5 µM 0.0231507780778963 0.47693521885926 no 1584 0.490765000737336 2352 7340576
SGTC_2435 5706476 10.6 µM 0.0216002383051089 0.477572249212704 no 1585 0.491383421718467 2363 5725375
SGTC_18 0111-0177 500 nM 0.0204575582119919 0.478041749533262 no 1586 0.491839184312224 2366 721752
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.0204091054407758 0.478061658313176 no 1587 0.491858510136373 2349 279621
SGTC_798 1287-0182 476 µM 0.0196251751729816 0.478383775329987 no 1588 0.492171190407513 2370 1649755
SGTC_1340 1486-1359 257 µM 0.0188490091015555 0.478702715950137 no 1589 0.492480778572966 2285 4309068
SGTC_472 calcifediol 10 µM 0.0177737526092611 0.479144580703022 no 1590 0.492909671917933 2318 5283731 A vitamin D metabolite.
SGTC_301 4119-0100 24.5 µM 0.0177468597689083 0.479155632348893 no 1591 0.492920398917055 2371 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2319 6033012 152.6 µM 0.0172403112823414 0.479363802057801 no 1592 0.493122451604254 2369 847246
SGTC_2244 6635614 200 µM 0.0172366543819774 0.479365304907589 no 1593 0.493123910279675 2358 836499
SGTC_3200 9114385 49.47 µM 0.0166578493808947 0.479603175879412 no 1594 0.493354786906149 2353 17018030 YLR208W SEC13
SGTC_3074 9116018 49.47 µM 0.015797552786863 0.479956744595961 no 1595 0.493697950393596 2368 17027303
SGTC_2749 bexarotene 57.39 µM 0.0154751217184643 0.480089262901849 no 1596 0.493826566054831 2356 82146 An retinoic acid receptor inhibitor.
SGTC_305 1682-2595 20.8 µM 0.0143032732887903 0.480570907894063 no 1597 0.494294014096177 2362 226033
SGTC_2971 9092186 9.93 µM 0.0138127007344167 0.480772548077265 no 1598 0.494489704889911 2369 25236400
SGTC_1041 0206-0046 107 µM 0.0136007172888203 0.480859681221342 no 1599 0.494574266105152 2293 50494
SGTC_1124 fisetin 1.16336 µM 0.0135831352790715 0.480866908127679 no 1600 0.494581279664341 2342 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1019 4262-0212 3.4 µM 0.0135566950245171 0.480877776137314 no 1601 0.494591826828651 2383 4677213
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.0128073611282487 0.481185788430551 no 1602 0.494890741823279 2377 6708561
SGTC_3154 9100113 49.47 µM 0.0122290195797789 0.481423522329286 no 1603 0.495121448639087 2368 25237525
SGTC_2360 9040895 200 µM 0.0114365751065399 0.481749276391268 no 1604 0.495437566104679 2365 4914414
SGTC_2395 5646831 180.19 µM 0.0109346105564765 0.48195562775517 no 1605 0.495637808457558 2378 6808628
SGTC_184 1494-0393 24.714 µM 0.0107654149614055 0.482025183045505 no 1606 0.495705303761024 2376 3090647
SGTC_1465 k213-0056 144 µM 0.0092480217932736 0.482648998445587 no 1607 0.496310625686178 2361 24048857 YMR208W ERG12
SGTC_2003 4023581 200 µM 0.00908363696850656 0.482716581257054 no 1608 0.496376202988248 2376 16641307
SGTC_2773 thioridazine 9.09 µM 0.00783651394830317 0.483229321507498 no 1609 0.496873715253119 2396 5452 An antipsychotic.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.00656164715420943 0.483753496953715 no 1610 0.497382300305393 2380 689007
SGTC_1429 4049-0205 9.46 µM 0.00585461869831629 0.4840442116102 no 1611 0.49766435840858 2389 22774478
SGTC_20 0481-0013 4.944 µM 0.0057332671517677 0.484094109572444 no 1612 0.497712769858673 2393 182045
SGTC_225 nsc-122657 1.016 µM 0.00534614905298238 0.484253288473633 no 1613 0.49786720526512 2391 275685
SGTC_3003 9075612 71.4286 µM 0.00515075412506279 0.484333633772825 no 1614 0.497945155489494 2386 6501993
SGTC_2504 purpurogallin 52.29 µM 0.00483681662461061 0.484462724444053 no 1615 0.498070396869676 2391 5281571 An antioxidant.
SGTC_158 k038-0087 26.446 µM 0.00467119302992423 0.484530829296945 no 1616 0.498136470377499 2385 X158
SGTC_1113 artemisinin 1.17947 µM 0.00459496839700758 0.484562173216004 no 1617 0.498166879279998 2398 2240 An anti-malaria and mitochondrial poison.
SGTC_256 clotrimazole 625 nM 0.0040278549329537 0.484795375858415 no 1618 0.498393122712816 2393 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3083 9117465 49.47 µM 0.00331872264749457 0.485086985346889 no 1619 0.498676023649351 2397 16420915
SGTC_762 1165-0429 115 µM 0.0026021817995296 0.485381649486092 no 1620 0.498961880830455 2402 5967793
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.0015924934836475 0.485796878598373 no 1621 0.499364687286639 2402 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1050 3232-1156 69.3 µM 0.00138048847216621 0.485884066537203 no 1622 0.499449264955773 2402 700529
SGTC_3338 9144300 39.5675 µM 0.000870498540679194 0.486093804764295 no 1623 0.499652721370955 2403 4901274
SGTC_2665 lovastatin 100 µM 0.000548078536385414 0.486226405056938 no 1624 0.499781348309802 2404 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2020 4017018 200 µM 0 0.486451814453266 no 1625 0.5 2405 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2687 chenodiol 100 µM 0 0.486451814453266 no 1626 0.5 2405 5702181 A cholesterol synthesis inhibitor.
SGTC_974 1326-0144 138 µM -0.00104253316245166 0.486880591117121 no 1627 0.499584089518118 2407 5411856
SGTC_1353 1498-1206 8.11 µM -0.00185457608951965 0.487214581488352 no 1628 0.499260131609793 2410 6756808
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.00350356795884992 0.487892833333244 no 1629 0.498602281468452 2414 676296 Flavone; oxidizing agent.
SGTC_268 camptothecin 39.6153 µM -0.00392674336421927 0.488066896616871 no 1630 0.498433460073557 2412 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_836 0330-0104 1.35 µM -0.00411224682945619 0.488143199837597 no 1631 0.498359455496043 2412 46494820
SGTC_623 k072-0108 16.9 µM -0.00488371025806649 0.488460530847937 no 1632 0.498051689237569 2418 5382803
SGTC_2365 9042475 200 µM -0.00489491756480975 0.48846514087577 no 1633 0.4980472182225 2422 6464479
SGTC_362 0310-0100 9.03 µM -0.00500544243833776 0.488510604400498 no 1634 0.498003125717667 2416 790235
SGTC_612 0302-0167 22.4 µM -0.0055311905694572 0.488726868732761 no 1635 0.497793385472444 2416 235821
SGTC_3135 9127742 49.47 µM -0.0056244368487443 0.488765225554279 no 1636 0.497756186167837 2422 3643468
SGTC_1997 st073024 93.8 µM -0.00580661984062539 0.488840166758207 no 1637 0.497683506856833 2414 686268
SGTC_1850 st056238 17 µM -0.00757733847961817 0.489568574232944 no 1638 0.496977108234684 2415 5393177
SGTC_2657 nystatin 74.44 µM -0.00790305957711966 0.489702567580601 no 1639 0.496847168210302 2431 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_318 1488-0629 67.2 µM -0.0085786588926221 0.489980495586792 no 1640 0.496577652235671 2438 3662576
SGTC_1160 4092-0570 10.5 µM -0.00883964671268454 0.490087862050751 no 1641 0.49647353710848 2420 4994975
SGTC_2889 9059656 51.95 µM -0.0107958555282448 0.490892639267624 no 1642 0.495693160437555 2429 3949838
SGTC_1078 idebenone 36.1 µM -0.010892608626432 0.490932444130723 no 1643 0.495654563805441 2441 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1991 st073000 8.92 µM -0.0117787742010417 0.491297022647195 no 1644 0.495301057614991 2435 4301969 YIL048W NEO1
SGTC_2756 carbadox 75.1 µM -0.0120252304151857 0.491398418819846 no 1645 0.495202742774921 2435 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3230 9131665 49.47 µM -0.0121835710240117 0.491463563065222 no 1646 0.495139578638886 2434 15943720
SGTC_3143 9086658 49.47 µM -0.0126548453556317 0.491657455353448 no 1647 0.494951581882636 2456 25236626
SGTC_2626 ethyl orsellinate 100 µM -0.0130510417301088 0.491820460499581 no 1648 0.494793535453578 2444 75653 A natural product.
SGTC_2411 st077133 39.94 µM -0.0133475047037395 0.491942433712944 no 1649 0.494675274141496 2464 1403142 YNL221C POP1
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.0151732277006138 0.49269360372599 no 1650 0.493946990201843 2454 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2045 5106652 78.05 µM -0.0153782917840856 0.492777976347368 no 1651 0.493865191013327 2431 673349
SGTC_2490 carminic acid 95.39 µM -0.0157147283450864 0.492916402234843 no 1652 0.493730988464058 2427 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2779 methotrexate 400 µM -0.0164070749872468 0.493201269000963 no 1653 0.493454817743091 2431 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2100 5377183 190 µM -0.0164648664094596 0.493225047502212 no 1654 0.49343176541523 2462 2844202
SGTC_77 0828-0286 12.516 µM -0.01665540573165 0.493303445803651 no 1655 0.493355761645924 2436 745345
SGTC_2880 9042983 58.44 µM -0.01667775594185 0.493312641919901 no 1656 0.493346846440396 2458 6464714
SGTC_3056 9094900 49.47 µM -0.0177081775001027 0.493736618286117 no 1657 0.492935828484906 2452 25236784
SGTC_411 enrofloxacin 100 µM -0.0177154672313478 0.493739617738421 no 1658 0.492932920759025 2444 71188 A bacterial gyrase inhibitor.
SGTC_1053 3366-3204 134 µM -0.0179636120081199 0.493841720261556 no 1659 0.492833941067519 2445 3632071 YPR165W RHO1
SGTC_953 1188-0045 9.7 µM -0.0182455720222096 0.493957737010531 no 1660 0.492721473730461 2452 6144426
SGTC_2455 5377712 9.75 µM -0.018298425837594 0.493979484576309 no 1661 0.492700391628417 2473 2243908
SGTC_433 pimozide 108 µM -0.0189575937526399 0.49425071146576 no 1662 0.49243746730367 2436 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1815 st051655 58.2 µM -0.0192141311372844 0.494356269265855 no 1663 0.492335142333376 2430 5984156
SGTC_1446 4239-0190 62 µM -0.0220528141914214 0.495524330916733 no 1664 0.491202913065901 2456 1340085
SGTC_500 h-89 112 µM -0.0229650238461908 0.495899695684952 no 1665 0.490839086256997 2445 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1199 1638-0010 4.46 µM -0.0230693595598171 0.495942628981595 no 1666 0.490797473354027 2447 3111136
SGTC_3094 9117742 49.47 µM -0.0258424697817503 0.497083756928599 no 1667 0.489691493580714 2456 17149698
SGTC_236 1509-0011 5.31 µM -0.0264003050875864 0.49731330795019 no 1668 0.489469025405555 2451 3107280
SGTC_1201 1889-3372 45.9 µM -0.0264951443498838 0.497352334702065 no 1669 0.489431203244273 2490 5392199
SGTC_85 0868-0259 160.055 µM -0.0270850655561387 0.497595090292556 no 1670 0.489195943175772 2525 83173
SGTC_2038 4100038 30.985 µM -0.0284005552179885 0.498136424083914 no 1671 0.488671340690591 2507 3596803
SGTC_3168 9103419 49.47 µM -0.0290381532081661 0.49839880170082 no 1672 0.488417080777294 2448 16649256
SGTC_2686 alizarin 95.37 µM -0.0303445266634096 0.498936388800452 no 1673 0.487896142882731 2488 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_114 0364-0001 490.298 µM -0.0304980430213161 0.498999562622274 no 1674 0.48783492704968 2484 4003655
SGTC_1685 st024049 53.0905 µM -0.0307765503441012 0.499114171787631 no 1675 0.487723870836932 2499 1941139
SGTC_2921 7974240 10.71 µM -0.0322792050896998 0.499732533592951 no 1676 0.487124696248314 2483 2979074 YDR527W RBA50
SGTC_2539 epi(13)torulosol 80 µM -0.0325732769401493 0.499853548073403 no 1677 0.487007440215403 2498 6708597
SGTC_1638 st008370 60.6 µM -0.0328733443542506 0.499977029821909 no 1678 0.48688779471365 2449 24207134
SGTC_829 1635-0120 117 µM -0.0329849819338217 0.499977029821909 no 1679 0.486843281902927 2491 285054
SGTC_822 1487-0950 154 µM -0.0330210069884771 0.499962205030429 no 1680 0.486828917810271 2454 1958375
SGTC_2021 4019055 173 µM -0.0332498898508667 0.499868016675522 no 1681 0.486737656873493 2497 44827708 YER133W GLC7
SGTC_1514 1189-1591 158 µM -0.0335769315695616 0.499733434654273 no 1682 0.486607258917144 2469 767698 YMR146C TIF34
SGTC_40 0327-0103 19.753 µM -0.0337048538046367 0.499680792958879 no 1683 0.486556254198437 2484 409036
SGTC_1995 st072814 61.1 µM -0.0339319246626422 0.499587350305167 no 1684 0.48646571782001 2476 5769371
SGTC_1056 3448-1962 115 µM -0.0342124290977945 0.499471919061347 no 1685 0.48635387767855 2507 715507
SGTC_1334 1486-0610 236 µM -0.0343728183093534 0.499405916822285 no 1686 0.486289929253028 2569 3742339
SGTC_1204 4049-0315 18.3 µM -0.0347127366156169 0.499266036090188 no 1687 0.486154402349139 2633 588402
SGTC_272 doxorubicin 8.13 µM -0.0348233854668373 0.499220502690852 no 1688 0.4861102865162 2448 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1021 4476-0760 85.3 µM -0.0352716943667216 0.499036018028268 no 1689 0.485931546952158 2472 746768
SGTC_1062 mesoridazine 14.2 µM -0.0356860458446815 0.498865507447642 no 1690 0.485766348634269 2476 4078 A neuroleptic.
SGTC_2088 5278280 127.392 µM -0.0357519909820334 0.498838370254534 no 1691 0.485740057108147 2500 791502
SGTC_2960 9079389 5.97 µM -0.0362208909899878 0.498645412595057 no 1692 0.485553114158401 2477 16457355
SGTC_2981 9013952 38.96 µM -0.0362320272445778 0.498640829903946 no 1693 0.485548674349861 2506 2996344
SGTC_496 calpeptin 138 µM -0.0370137830477176 0.49831912928535 no 1694 0.485237007994321 2532 73364 A calpain inhibitor.
SGTC_1591 genipin 88.4 µM -0.0383301061894811 0.497777451241645 no 1695 0.484712243574785 2588 442424 A DNA cross-linking agent.
SGTC_1151 3909-8316 15.3 µM -0.0386590443777433 0.497642091011565 no 1696 0.484581113416894 2551 800431
SGTC_421 streptovitacin 30 mM -0.0392844967854302 0.497384713989756 no 1697 0.48433178342412 2631 91467 include heat shock
SGTC_2875 9039966 71.43 µM -0.0397085018690012 0.497210234235312 no 1698 0.484162761756529 2562 6463691
SGTC_2926 9010726 65.15 µM -0.0400343924256199 0.497076129354376 no 1699 0.484032853535982 2527 2994293
SGTC_444 curcumin 90.4 µM -0.0406063037362151 0.49684078704891 no 1700 0.483804879324298 2509 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1619 st003326 88.7 µM -0.0410996367352212 0.496637780708962 no 1701 0.483608232101841 2478 2849032
SGTC_2980 9014342 25.29 µM -0.0411053638101355 0.496635424024841 no 1702 0.483605949258665 2596 2996599
SGTC_2037 5169046 200 µM -0.0411771792207134 0.496605872083748 no 1703 0.483577323291478 2538 5718022
SGTC_1673 st016611 27.3 µM -0.0422204865936972 0.49617655474096 no 1704 0.483161465590153 2599 5226799
SGTC_1278 0874-0585 172 µM -0.0423056155164538 0.496141524675029 no 1705 0.483127534380504 2510 766306
SGTC_781 4335-2806 94.4 µM -0.0432978760380804 0.495733217397826 no 1706 0.482732042156222 2608 845254
SGTC_1929 genistein trimethyl ether 50.5 µM -0.0443500989379644 0.495300240973509 no 1707 0.482312668877771 2486 136420
SGTC_2801 7907800 81.82 µM -0.0443712476729204 0.49529153859142 no 1708 0.482304240050716 2521 6620925
SGTC_593 1203-0218 61.7 µM -0.0444486837782561 0.495259674833496 no 1709 0.482273377963087 2495 3666956
SGTC_946 3434-1334 87.4 µM -0.0451740782320745 0.49496118774764 no 1710 0.481984277862743 2534 4047976
SGTC_3024 9090631 49.47 µM -0.0454776482106359 0.494836274857313 no 1711 0.481863295302883 2486 25236383
SGTC_372 0155-0182 15.9 µM -0.0458020070275151 0.494702808341378 no 1712 0.481734029557385 2490 771486
SGTC_246 cycloheximide 667 µM -0.0475760671638276 0.493972832516094 no 1713 0.481027053030838 2487 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_771 0250-0039 27.3 µM -0.0477648508092491 0.493895154503475 no 1714 0.480951824778595 2492 3005115
SGTC_1239 0337-0584 35.4 µM -0.0485625241635479 0.493566941793503 no 1715 0.480633968046535 2553 914301 YML130C ERO1
SGTC_913 3487-1245 167 µM -0.0501219204134823 0.492925321423507 no 1716 0.480012615863059 2499 4016153
SGTC_1317 1273-0028 910 nM -0.0513378001445008 0.492425055034049 no 1717 0.479528173821837 2513 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1217 1183-1422 255 µM -0.0516154662734639 0.49231081262093 no 1718 0.479417547731581 2550 2849664
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.0516748965396544 0.492286360829192 no 1719 0.479393870083535 2489 77254
SGTC_3184 9108758 49.47 µM -0.0519506708159669 0.492172897555773 no 1720 0.479283999641384 2471 902885
SGTC_2831 7999036 19.48 µM -0.0524688701571617 0.49195969377221 no 1721 0.479077549585636 2587 2988270
SGTC_3315 9136395 68.55 µM -0.0528410949175117 0.491806550014207 no 1722 0.478929259105507 2502 16876844
SGTC_2639 lactacystin 53 µM -0.0534245856821199 0.491566487906309 no 1723 0.478696808320016 2527 3870 A proteasome inhibitor.
SGTC_2443 5493264 126.67 µM -0.0541977958881025 0.491248375386224 no 1724 0.478388788365968 2544 5340055
SGTC_2084 5306078 60.6385 µM -0.056023930225296 0.490497093491474 no 1725 0.477661371766757 2555 679340
SGTC_3001 9076041 71.4286 µM -0.0560298258683351 0.490494668044067 no 1726 0.477659023434094 2512 16004211
SGTC_1044 1222-0021 1.78 µM -0.0566138792581365 0.49025439223124 no 1727 0.477426389114562 2638 4306703
SGTC_2127 5253358 187.912 µM -0.0567370445260727 0.490203723279776 no 1728 0.477377332133199 2503 20612
SGTC_3042 9091578 49.47 µM -0.0575299545220777 0.489877531909047 no 1729 0.477061522678773 2485 25236497
SGTC_1260 0700-1617 7.75 µM -0.0578961890789797 0.489726870735786 no 1730 0.476915659353371 2543 2853078
SGTC_748 act1.228 77.9 µM -0.0583273562559203 0.489549499532276 no 1731 0.476743938731213 2512 4421505 YNR035C ARC35
SGTC_3158 9100007 49.47 µM -0.0585784417265298 0.489446210309661 no 1732 0.476643941100284 2524 19297233
SGTC_1960 st011366 51.8 µM -0.0590175733988371 0.489265566082381 no 1733 0.476469055480156 2512 3972846
SGTC_2674 ligustilide 100 µM -0.0592351648138403 0.489176056993768 no 1734 0.476382400666962 2562 5319022 A signalling regulator.
SGTC_2462 5162487 171.77 µM -0.0604473160900907 0.488677432736507 no 1735 0.475899687368236 2501 2259986
SGTC_1071 trifluoperazine 6.31 µM -0.0628554539967735 0.487686886888081 no 1736 0.474940803611586 2627 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3340 9146634 11.102 µM -0.062993208812982 0.487630226067284 no 1737 0.474885956082283 2542 4907387
SGTC_49 0717-0965 32.132 µM -0.0633818863643686 0.487470357949796 no 1738 0.47473120541701 2774 5889349 YGL099W LSG1
SGTC_2912 7964298 10.93 µM -0.0635475484284881 0.487402219604873 no 1739 0.474665248778387 2567 2975850
SGTC_457 grayanotoxin iii 135 µM -0.0640713215068364 0.487186789304015 no 1740 0.474456718517397 2573 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_124 0136-0217 7.121 µM -0.0646203322890958 0.486960982632818 no 1741 0.47423814785877 2538 3976905
SGTC_689 0833-0039 98 µM -0.0652740515017101 0.486692115121488 no 1742 0.473977901087553 2572 5374726
SGTC_2780 5215298 71.43 µM -0.0654048116396753 0.486638335639154 no 1743 0.473925846575282 2531 2834131
SGTC_1829 berberine 14.4 µM -0.0673272148186504 0.485847711564877 no 1744 0.473160605873107 2668 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2938 9059746 27.26 µM -0.067498249675184 0.48577737294697 no 1745 0.473092527703196 2590 6471769
SGTC_3241 9133421 49.47 µM -0.0676745213934951 0.485704881116386 no 1746 0.473022365891905 2509 17018221
SGTC_724 3910-0327 137 µM -0.0678195090366732 0.485645255231017 no 1747 0.472964656775583 2555 2885483
SGTC_2611 pyromycin 23.93 µM -0.0682504892947546 0.485468017340824 no 1748 0.472793117995723 2561 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.0695807296793094 0.484920982700984 no 1749 0.472263687624149 2530 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2693 st077581 40.7 µM -0.0708278670634518 0.48440814825512 no 1750 0.471767376403028 2531 25238761
SGTC_2293 7624732 200 µM -0.070939542351008 0.484362227587857 no 1751 0.471722936194431 2533 894453
SGTC_1657 st012939 43.4 µM -0.0718238979970172 0.483998589590882 no 1752 0.471371027040943 2594 24207257
SGTC_1490 4089-0339 670 nM -0.0764345994573063 0.482102938744957 no 1753 0.46953667186105 2545 742542
SGTC_2567 aureobasidin a 60 nM -0.0770890595030989 0.48183389483645 no 1754 0.469276348176338 2738 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1129 3453-1384 223 µM -0.0774436759829374 0.481688117951024 no 1755 0.469135298339201 2741 1084452
SGTC_2879 9041815 71.43 µM -0.0777604790737134 0.481557887585613 no 1756 0.469009292173794 2541 4942971
SGTC_1611 st001856 99.4 µM -0.0778457220487704 0.481522846521156 no 1757 0.46897538791909 2554 647478
SGTC_519 k048-0011 62.8 µM -0.0784470651241018 0.481275654838637 no 1758 0.468736218148995 2666 6836379
SGTC_894 0960-0238 55.9 µM -0.0789288597330179 0.481077610654054 no 1759 0.468544604047753 2513 6741907 YDL195W SEC31
SGTC_1895 st058434 18.3 µM -0.0795610489377971 0.480817753079101 no 1760 0.468293187707054 2549 5393175
SGTC_2928 9011484 9.79 µM -0.079663755008395 0.480775537132517 no 1761 0.468252343556234 2614 2994751
SGTC_2964 9083345 53.42 µM -0.080184640184654 0.480561437627998 no 1762 0.468045203090142 2584 17741579
SGTC_3263 9137018 49.47 µM -0.0801853137407806 0.480561160779749 no 1763 0.468044935242591 2553 43844957
SGTC_1853 st056710 91.2 µM -0.0809968651751117 0.480227599891861 no 1764 0.467722222771489 2705 269167
SGTC_356 1634-0012 32.5 µM -0.0810237673543967 0.480216542892793 no 1765 0.467711525513684 2544 735457
SGTC_2286 7945697 125 µM -0.0813077402267038 0.480099828825452 no 1766 0.467598609281329 2609 1245733
SGTC_869 0564-0080 44.1 µM -0.0813973056980597 0.480063017386372 no 1767 0.467562995872076 2602 6843321
SGTC_2528 xanthyletin 44.79 µM -0.0818981292613099 0.479857181874554 no 1768 0.467363861038404 2582 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1226 3909-7979 35.4 µM -0.0824407909837565 0.479634157192314 no 1769 0.467148099956889 2642 6615510
SGTC_2677 mitomycin C 100 µM -0.0837270836299416 0.479105538519556 no 1770 0.466636711561858 2558 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2463 5473429 200 µM -0.0841246045562048 0.478942179521313 no 1771 0.466478681186445 2636 5399405
SGTC_2998 9066762 71.4286 µM -0.0847095536095122 0.478701804424098 no 1772 0.466246150294195 2633 4945196
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.084857546080238 0.478640990600906 no 1773 0.466187321658397 2578 65057 A dermal irritant. YDR527W RBA50
SGTC_669 0108-0021 26.2 µM -0.0853142829281888 0.478453309100429 no 1774 0.466005768398842 2527 17201
SGTC_55 0767-0285 6.563 µM -0.0858141758850919 0.478247899445648 no 1775 0.465807068661616 2561 3116166
SGTC_1205 4161-2785 76 µM -0.0866709360183172 0.477895863937994 no 1776 0.46546653957833 2700 3498106
SGTC_1060 3448-7350 82 µM -0.0868147023921812 0.477836793230705 no 1777 0.465409400464614 2597 570178
SGTC_664 1222-0054 14.9 µM -0.0870599039042925 0.477736045992326 no 1778 0.465311948187969 2586 6813991
SGTC_752 1896-0090 130 µM -0.087516734066262 0.477548349574187 no 1779 0.465130392302026 2567 772567
SGTC_1616 st002734 56.1 µM -0.0886176112277442 0.47709605606716 no 1780 0.464692905707701 2590 4026101
SGTC_950 1165-0508 94.1 µM -0.0887440553818518 0.477044108579688 no 1781 0.464642659751895 2613 6148369
SGTC_1247 0448-0043 5.84 µM -0.0891160115099715 0.476891298826899 no 1782 0.464494856339258 2640 3089013 YGL099W LSG1
SGTC_274 sirtinol 40.1 µM -0.089404558877329 0.476772758014084 no 1783 0.464380200261247 2605 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_499 genistein 192 µM -0.0898716124339446 0.476580887783149 no 1784 0.464194619919406 2550 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2809 7964133 12.99 µM -0.0909629951731114 0.476132558178948 no 1785 0.463760997344586 2604 1253665
SGTC_1545 lovastatin 49.4 µM -0.0909885880113284 0.476122045245813 no 1786 0.463750829444326 2609 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1712 st032288 53.4 µM -0.0914146975295061 0.475947011973197 no 1787 0.463581541853817 2578 2883011
SGTC_1653 st012112 65 µM -0.0920738850937189 0.475676246241911 no 1788 0.463319668486833 2658 720429
SGTC_1272 0839-0021 27 µM -0.093613473661776 0.475043893837235 no 1789 0.462708103092297 2654 5027250
SGTC_1432 4049-0298 68.4 µM -0.0938144936163427 0.474961333883394 no 1790 0.462628259111588 2619 741646
SGTC_2187 6125751 200 µM -0.0940445858589384 0.474866835107608 no 1791 0.462536869632017 2599 874498
SGTC_2337 9009472 200 µM -0.0943525130703245 0.47474037175995 no 1792 0.462414568266505 2605 5742383
SGTC_662 k832-1615 104 µM -0.0957521000849036 0.47416560435223 no 1793 0.46185873053718 2645 5878478
SGTC_1357 1503-1303 39.5 µM -0.0964314469318645 0.473886636773971 no 1794 0.461588958727945 2581 292895
SGTC_451 chloral hydrate 100 µM -0.0964329692990764 0.473886011642108 no 1795 0.461588354208607 2679 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2556 citropten 84.59 µM -0.097082913268916 0.473619130098028 no 1796 0.461330274997218 2573 2775 A potential DNA crosslinker.
SGTC_1417 3966-0327 90.4 µM -0.0985883655396969 0.473001003369253 no 1797 0.460732553984435 2604 651118
SGTC_866 0495-0101 262 µM -0.0994221409109739 0.472658689710231 no 1798 0.460401551975346 2610 635694
SGTC_1152 3909-8331 15.9 µM -0.102660209244428 0.471329466651083 no 1799 0.459116327575311 2595 16001939
SGTC_2761 levamisole 97.89 µM -0.104636725467417 0.470518265172957 no 1800 0.458332035972141 2619 26879 An alkaline phosphatase inhibitor.
SGTC_887 0885-0007 9.62 µM -0.105044827516321 0.470350787119425 no 1801 0.458170119122649 2747 5719458
SGTC_3260 9137109 49.47 µM -0.10515579405116 0.470305249269957 no 1802 0.458126093706956 2556 17478346
SGTC_2415 st077333 57.7 µM -0.105254714278483 0.470264655246718 no 1803 0.45808684803638 2578 2766255
SGTC_491 tetrandrine 80.3 µM -0.105510174265042 0.470159823227969 no 1804 0.457985498578558 2680 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_892 0929-0076 29 µM -0.10562273166607 0.470113634186129 no 1805 0.45794084418729 2599 5751038
SGTC_1520 flindersine 88 µM -0.106047838241798 0.469939191134227 no 1806 0.457772198361667 2866 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2366 9070441 60.58 µM -0.106240265480669 0.469860230254199 no 1807 0.457695862236551 2610 6837235
SGTC_2592 piperlongumine 83.33 µM -0.108307577715666 0.469012001668084 no 1808 0.456875855915356 2667 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2440 5628896 157.78 µM -0.108838939762523 0.468794003718321 no 1809 0.456665118898893 2619 5522048
SGTC_1031 k035-0009 16 µM -0.108906615816681 0.468766239437897 no 1810 0.456638279598716 2774 5180959
SGTC_1870 st057514 26.5 µM -0.109359977455406 0.468580250548818 no 1811 0.456458488332368 2584 5393161
SGTC_633 0437-0093 97.7 µM -0.109469631524349 0.46853526665399 no 1812 0.456415003758599 2586 2831118
SGTC_2000 st075254 36.4 µM -0.110193275643449 0.468238412886818 no 1813 0.45612804752887 2604 17234175
SGTC_596 1155-0152 116 µM -0.110791128292314 0.467993174693961 no 1814 0.455890990318553 2600 280313
SGTC_2495 cafestol 54.53 µM -0.111276227720536 0.467794196612372 no 1815 0.455698652923672 2806 16667697 An anti-infammatory.
SGTC_2941 9056145 11.23 µM -0.111860039974465 0.467554739177707 no 1816 0.45546719058493 2574 2119517
SGTC_873 0591-4978 488 µM -0.111958383583427 0.467514403547569 no 1817 0.455428202067002 2780 3305145
SGTC_2203 7227154 166.4 µM -0.112994974354163 0.467089266221365 no 1818 0.455017269790623 2604 896304
SGTC_2056 5235370 200 µM -0.113316116540334 0.46695756366145 no 1819 0.454889970192778 2649 5511916
SGTC_2216 7189485 200 µM -0.113614973893463 0.466835003510164 no 1820 0.454771508383049 2634 731273
SGTC_3167 9103034 49.47 µM -0.113960104845852 0.466693470662509 no 1821 0.454634709536022 2601 5127859
SGTC_270 tamoxifen 5.46 µM -0.114017754283838 0.466669829932629 no 1822 0.454611859670625 2638 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_3279 9140807 49.47 µM -0.115853303195598 0.465917174785304 no 1823 0.453884402525248 2611 45595718
SGTC_700 3453-2283 142 µM -0.117541021479543 0.465225244139571 no 1824 0.453215669440731 2750 565664
SGTC_308 4092-1169 104 µM -0.118381165814345 0.464880840874236 no 1825 0.452882824169111 2630 2268590 YDL196W YDL196W
SGTC_930 2810-3379 265 µM -0.119066728341106 0.464599825342991 no 1826 0.452611245061896 2773 1015764
SGTC_1620 st003704 16.5 µM -0.119153262337355 0.464564355874364 no 1827 0.4525769670112 2629 2834414
SGTC_2651 TUB2.036 5 µM -0.119333575582158 0.464490448081568 no 1828 0.452505542039186 2690 15992207 YFL037W TUB2
SGTC_2104 5389443 200 µM -0.119401087234541 0.464462776346171 no 1829 0.452478799984782 2750 2244536
SGTC_1624 st003710 6.25 µM -0.119417548829485 0.464456029079232 no 1830 0.452472279411734 2699 24207033
SGTC_2488 5268135 45.7 µM -0.120083594537575 0.464183039328078 no 1831 0.452208464003376 2727 1270356 YLR208W SEC13
SGTC_766 1391-0721 126 µM -0.120797142304794 0.463890598789982 no 1832 0.451925856820472 2779 1020919 YIL115C NUP159
SGTC_1390 3413-2614 145 µM -0.122708129596533 0.463107495952296 no 1833 0.451169113017497 2666 3421432
SGTC_3101 9120531 49.47 µM -0.126274203655889 0.461646540248173 no 1834 0.449757437643884 2785 24824904
SGTC_3122 9126309 49.47 µM -0.126531127814157 0.46154130283762 no 1835 0.449655755309529 2611 17591206
SGTC_2241 6772625 37.8075 µM -0.126599901888646 0.461513133091904 no 1836 0.449628537299123 2595 2285411
SGTC_1802 st050112 57.9 µM -0.12683994116247 0.461414814921382 no 1837 0.449533541274366 2602 4662563
SGTC_615 k087-0205 167 µM -0.126998072737848 0.46135004677842 no 1838 0.449470961965721 2644 9642773
SGTC_2326 6164455 177.58 µM -0.127239216450009 0.461251280177174 no 1839 0.449375533686607 2698 2888790
SGTC_1878 temozolomide 1 mM -0.127678810410824 0.461071239332993 no 1840 0.449201579835007 2623 5394 DNA alkylating agent.
SGTC_3288 9119690 36.221 µM -0.12783243726253 0.461008321539999 no 1841 0.449140789711264 2667 17595618 YKL019W RAM2
SGTC_2418 pentamidine 31.67 µM -0.128262376009402 0.460832245554607 no 1842 0.448970669359274 2601 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1968 st069590 43.6 µM -0.129520509109457 0.460317037267804 no 1843 0.448472898855743 2728 6384066
SGTC_657 3534-0529 86.7 µM -0.129906205830827 0.460159106908632 no 1844 0.448320317177476 2762 1049549
SGTC_1207 2099-0101 141 µM -0.129982917507934 0.460127696701263 no 1845 0.448289970937755 2723 5837381
SGTC_1547 harmine 94.2 µM -0.130650108096411 0.459854520713319 no 1846 0.448026050945717 2662 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1015 4130-4525 82 µM -0.130952459437577 0.459730731544473 no 1847 0.447906457660334 2654 1363237
SGTC_109 0132-0036 33.701 µM -0.131334662361657 0.45957425500071 no 1848 0.447755286330773 2609 67274 A color developer.
SGTC_2717 st081029 62.2815 µM -0.131747212414307 0.459405361158857 no 1849 0.447592120428444 2666 5292846
SGTC_2507 purpurin 79.67 µM -0.132742408983048 0.458997967904533 no 1850 0.447198551053165 2624 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1571 st070080 73.4 µM -0.134138997607056 0.458426333668365 no 1851 0.44664633132728 2769 4315245
SGTC_1654 st012436 41.8 µM -0.135171033487065 0.45800396878356 no 1852 0.446238324401381 2655 4323132
SGTC_2117 5521686 200 µM -0.137822636002679 0.456919008216206 no 1853 0.445190297068609 2656 803312
SGTC_3286 9117135 37.221 µM -0.139167688017482 0.45636877329284 no 1854 0.444658820611342 2696 3438150
SGTC_3098 9119039 49.47 µM -0.139856261104087 0.456087123587676 no 1855 0.444386780066306 2632 17161528
SGTC_37 0566-0070 1.56 µM -0.140486617938983 0.455829305641428 no 1856 0.44413776248591 2775 1626686
SGTC_2837 9008476 45.46 µM -0.142583281708943 0.454971897914458 no 1857 0.443309650912556 2852 2992805
SGTC_462 ag-879 158 µM -0.143993638567094 0.454395265634959 no 1858 0.442752746487491 2755 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1337 1486-1011 40.3 µM -0.145229015291075 0.453890253873449 no 1859 0.442265028946514 2667 X1337
SGTC_3350 9150499 3.57 µM -0.14525153561221 0.453881048442251 no 1860 0.442256138901072 2661 4910996 YPR165W RHO1
SGTC_2310 7668677 200 µM -0.146652339654226 0.453308503140832 no 1861 0.441703219595758 2820 2197143
SGTC_1501 4491-0275 38.4 µM -0.147279740647543 0.453052099316215 no 1862 0.441455611355384 2663 5104718
SGTC_1531 st059297 52.4 µM -0.14783532053917 0.452825063399462 no 1863 0.441236366917994 2781 7566702
SGTC_2932 9016711 44.54 µM -0.148095378709045 0.45271879676782 no 1864 0.441133748243583 2730 7117328
SGTC_833 3852-0053 558 µM -0.15008001477166 0.451907934175309 no 1865 0.440350743645623 2823 3123681
SGTC_1636 st007707 68.9 µM -0.150810895009851 0.45160936885193 no 1866 0.440062445797362 2785 403051
SGTC_2134 5324836 1.464 µM -0.150877831681156 0.451582026518902 no 1867 0.440036044017586 2721 699272
SGTC_2605 digitonin 300 nM -0.151266626689057 0.451423215838517 no 1868 0.439882697177544 2670 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1293 1000-1278 195 µM -0.15162585495028 0.451276489164843 no 1869 0.439741019940601 2784 678847
SGTC_1630 st005209 31.3 µM -0.151648797454898 0.451267118531766 no 1870 0.43973197183134 2649 3367314
SGTC_417 st075190 100 µM -0.152226288836617 0.45103125699882 no 1871 0.439504230046721 2796 222757
SGTC_2934 9036370 36.88 µM -0.153128384603739 0.450662853763722 no 1872 0.439148516082891 2776 6462800
SGTC_90 0870-0863 4.608 µM -0.153261998785828 0.450608291215443 no 1873 0.439095833574492 2658 1738164
SGTC_2882 9058044 58.44 µM -0.153811342627702 0.45038397155523 no 1874 0.438879245072058 2762 18076804
SGTC_3330 9141424 71.43 µM -0.154197129270908 0.450226448488139 no 1875 0.438727152815581 2813 27261020
SGTC_3050 9093513 49.47 µM -0.155754522019277 0.449590619242206 no 1876 0.438113259597081 2696 25236664
SGTC_3008 9078912 71.4286 µM -0.155777672424448 0.44958116870969 no 1877 0.438104135287716 2715 16648731
SGTC_3306 9127676 59.7925 µM -0.15657692150455 0.449254914264483 no 1878 0.437789146071573 2743 41905287
SGTC_784 4579-0127 173 µM -0.156825265962838 0.449153546730367 no 1879 0.437691279936614 2889 1948547
SGTC_1200 1643-0193 18.4 µM -0.156909158886815 0.449119304642798 no 1880 0.437658220763629 2662 5403974
SGTC_687 k029-0044 34.9 µM -0.156951132346497 0.449102172721734 no 1881 0.437641680701636 2792 5829338
SGTC_990 3985-0011 41.3 µM -0.157271906325713 0.448971248492329 no 1882 0.437515280104183 2761 5399565 YGL099W LSG1
SGTC_943 3253-1379 105 µM -0.157449145005142 0.448898910725335 no 1883 0.43744544215172 2812 668464
SGTC_2555 cholic acid 100 µM -0.158007652323869 0.448670974016971 no 1884 0.437225384392693 2852 6708657 Influences liver metabolism.
SGTC_1854 st056233 32.9 µM -0.158610082675684 0.448425130537294 no 1885 0.436988042268232 2663 5393174
SGTC_2850 9015429 58.44 µM -0.159864229160961 0.447913394371833 no 1886 0.436494013527165 2751 6457570
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.159875801573732 0.447908672820012 no 1887 0.43648945542515 2707 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1674 st016616 23.6 µM -0.160458392419134 0.447670984934358 no 1888 0.436259997464532 2646 625830
SGTC_192 3455-0609 60.9 µM -0.160782700691227 0.447538680404596 no 1889 0.436132275403726 2808 3769639
SGTC_1499 4480-0877 67.3 µM -0.1619736988385 0.447052851992141 no 1890 0.435663282817219 2698 2861909
SGTC_2869 9037858 32.47 µM -0.165238926694888 0.44572131957618 no 1891 0.434377963646337 2668 27187042
SGTC_3020 9089140 49.47 µM -0.165340998026186 0.44567970553346 no 1892 0.434337795553262 2766 17217859
SGTC_221 trifluoperazine 10.304 µM -0.166498706204518 0.445207754884373 no 1893 0.433882250630273 2713 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_188 3229-0966 278.469 µM -0.168123430674365 0.444545551738316 no 1894 0.433243088347079 2727 5722370
SGTC_783 0848-0141 92.7 µM -0.168790097405184 0.444273877226956 no 1895 0.432980873845995 2682 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.169254315448488 0.444084718384734 no 1896 0.432798304228191 2700 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1555 citronellol 128 µM -0.169433437536947 0.444011733399401 no 1897 0.432727862175582 2715 8842 A terpine precursor.
SGTC_1652 st011932 78 µM -0.169658043305907 0.443920218342703 no 1898 0.432639536105084 2771 1551076
SGTC_804 1595-0054 20.9 µM -0.170280959502519 0.443666428363807 no 1899 0.432394592346043 2713 761523 Stimulates phospholipase C.
SGTC_2729 fluphenazine 10.66 µM -0.170730708828825 0.443483204793648 no 1900 0.432217757590189 2723 3372 An atypical antipsychotic.
SGTC_562 3772-2733 112 µM -0.170874657816234 0.443424563904693 no 1901 0.432161161852849 2804 2876874 YIL048W NEO1
SGTC_376 3970-0862 59.1 µM -0.171532472348489 0.443156604003351 no 1902 0.431902549781552 2819 3135186
SGTC_178 4092-0806 87.505 µM -0.171825744751457 0.443037148238798 no 1903 0.43178726257246 2696 2169044
SGTC_478 N-arachidonylglycine 10 µM -0.172777790414153 0.442649396578461 no 1904 0.431413047579682 2697 5283389
SGTC_3038 9091290 49.47 µM -0.173237741425177 0.442462086177168 no 1905 0.431232279370062 2832 25236843
SGTC_1302 1159-0335 255 µM -0.173830860343997 0.442220563483136 no 1906 0.430999195279463 2695 649284
SGTC_1776 st049249 45.9 µM -0.174127268103616 0.44209987195178 no 1907 0.430882721849444 2751 1822314
SGTC_1583 clindamycin 39.6 µM -0.174584770860995 0.441913596193349 no 1908 0.430702957942956 2713 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_180 1486-1293 102.781 µM -0.176224086066889 0.441246242182957 no 1909 0.430058949473247 2760 4140536
SGTC_317 4495-0002 170 µM -0.176819456429256 0.441003912166563 no 1910 0.429825102917806 2757 15991618
SGTC_2976 9009005 19.48 µM -0.178414775403437 0.44035468821722 no 1911 0.429198623185464 2930 2993148
SGTC_1091 telmisartan 47.6 µM -0.179356892145938 0.439971363735968 no 1912 0.42882873877318 2824 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_3297 9117502 71.43 µM -0.180512754422906 0.439501148267005 no 1913 0.428375021141824 2709 7453720
SGTC_3019 9081971 49.47 µM -0.180766254613493 0.439398033431824 no 1914 0.428275525810295 2863 16451803
SGTC_1875 nocodazole 6 µM -0.181197342646502 0.439222691641871 no 1915 0.428106340169929 2728 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2402 5553605 200 µM -0.183261702988807 0.438383194586174 no 1916 0.427296341025467 2909 6758546
SGTC_2238 6671620 73.2395 µM -0.183461436548564 0.438301985168871 no 1917 0.427217987183017 2677 729941
SGTC_1782 st039423 80.636 µM -0.184234903615865 0.437987526705238 no 1918 0.426914589490708 2786 2068169
SGTC_2364 9055074 200 µM -0.184961046715193 0.437692343763527 no 1919 0.426629794286206 2822 6470630
SGTC_1469 k284-2957 126 µM -0.185055915997124 0.437653781203659 no 1920 0.426592589129911 2763 23884841
SGTC_1511 0906-3109 28.5 µM -0.186584925427034 0.437032349865068 no 1921 0.425993043471941 2714 2882180
SGTC_284 0988-0104 32.6 µM -0.187421702634951 0.436692326340416 no 1922 0.425665003923819 2838 4666532
SGTC_599 1935-0052 86.5 µM -0.187829908296764 0.436526469362611 no 1923 0.425504994796535 2744 9557311
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.187963897083697 0.436472031159051 no 1924 0.425452476324295 2780 140250 A respiratory chain inhibitor.
SGTC_1492 4158-0558 28.5 µM -0.190181333605849 0.435571286030039 no 1925 0.424583518899947 2850 3967268
SGTC_2433 5607874 27.82 µM -0.191882345450536 0.434880544051151 no 1926 0.423917183381914 2742 2252428
SGTC_2188 6126565 140.678 µM -0.19295024456271 0.434446996056467 no 1927 0.423498967419102 2852 874518
SGTC_2847 9005661 71.43 µM -0.193118569981702 0.434378666116489 no 1928 0.423433054830567 2736 2991449
SGTC_3029 9088683 49.47 µM -0.193669681164002 0.434154962034034 no 1929 0.423217266628151 2887 25236615
SGTC_1242 0402-0103 60.1 µM -0.194464057390631 0.433832550232464 no 1930 0.422906268263844 2739 432868
SGTC_1743 st037606 46.3785 µM -0.195873226646278 0.433260722115022 no 1931 0.422354696686387 2764 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2412 st077135 33.4 µM -0.196519264112866 0.432998612593278 no 1932 0.422101878027955 3032 13258915
SGTC_214 4373-3496 70 µM -0.196928289293798 0.432832678632868 no 1933 0.421941827741027 2785 3779166
SGTC_1123 mangostin 811.285 nM -0.197047283443459 0.432784407126976 no 1934 0.421895268118245 2846 5281650 An antioxidant.
SGTC_589 1227-0070 34.1 µM -0.197758514156356 0.432495908187567 no 1935 0.421617002988814 2876 2841384
SGTC_2608 thymoquinone 42.66 µM -0.198384987698466 0.432241819390651 no 1936 0.421371931052758 2724 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1279 0874-0590 65.2 µM -0.198453471318853 0.432214045101233 no 1937 0.421345142598873 2814 3523074
SGTC_1274 0865-0114 173 µM -0.199201442031473 0.431910719147671 no 1938 0.421052585724931 2802 870624
SGTC_2830 7992007 71.43 µM -0.20125638696984 0.431077580638488 no 1939 0.420249051466005 2658 1952075
SGTC_1311 1190-0148 100 µM -0.201305471790782 0.43105768386189 no 1940 0.420229862137804 2877 1961333
SGTC_1266 0828-0227 32.9 µM -0.201429618405509 0.431007361194401 no 1941 0.420181328832671 2882 3913820
SGTC_2568 diosmetin 100 µM -0.20153806334842 0.430963404095494 no 1942 0.420138934859801 2826 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_3237 9133362 49.47 µM -0.201925657799813 0.430806303462773 no 1943 0.419987421598626 2878 43845137
SGTC_3152 9099253 49.47 µM -0.203535674372737 0.430153845488378 no 1944 0.419358182535277 2866 25236131
SGTC_2308 7584454 197.62 µM -0.203913124572822 0.430000911610256 no 1945 0.41921069431865 2910 893577
SGTC_228 caffeine 993.056 µM -0.20418924176441 0.429889042116001 no 1946 0.419102809042584 2894 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_521 r062-0005 13.8 µM -0.204456064363595 0.429780943693994 no 1947 0.418998561154142 2733 2832033
SGTC_2645 abamectin 100 µM -0.206601085760033 0.428912118426551 no 1948 0.418160706122761 2875 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2222 6885208 172.143 µM -0.207140324589668 0.428693757669756 no 1949 0.417950135250603 2809 609514
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.208023529265219 0.428336157677654 no 1950 0.417605297755669 2886 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1990 st072050 59.8 µM -0.208118626655755 0.428297657279336 no 1951 0.41756817180479 2732 17233948
SGTC_2271 7849410 118.62 µM -0.208982866765139 0.427947799002329 no 1952 0.417230806826943 2752 972430
SGTC_1304 1165-0502 251 µM -0.209111019537595 0.42789592551692 no 1953 0.417180786260938 2815 767425
SGTC_1809 st050081 57.6 µM -0.210136904571936 0.427480714315001 no 1954 0.416780411388513 2929 5036894
SGTC_1244 0416-0015 52.5 µM -0.210915302079037 0.427165723446207 no 1955 0.41647668169164 2808 96201
SGTC_2873 9040596 71.43 µM -0.211236489832344 0.427035763259908 no 1956 0.416351369168875 2881 6463863
SGTC_3226 9131256 49.47 µM -0.211273197484472 0.42702091097682 no 1957 0.416337048091413 2775 17178073
SGTC_252 miconazole 1.30953 nM -0.211482534240995 0.426936213209897 no 1958 0.416255379834471 2864 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1631 benzylvanillin 81.9 µM -0.212460422233896 0.426540603871108 no 1959 0.415873925702887 2937 75506
SGTC_2852 9023854 51.95 µM -0.213166487650755 0.42625500759152 no 1960 0.415598553250044 2944 19798528
SGTC_582 0987-0078 156 µM -0.213245422961572 0.426223081461627 no 1961 0.415567770276089 2810 1625765
SGTC_2013 4024628 200 µM -0.21403180482415 0.425905048346064 no 1962 0.415261127578515 2939 5230760
SGTC_2769 toremifene 3.73 µM -0.214437923722515 0.42574082224158 no 1963 0.415102785279115 2958 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3141 9094609 49.47 µM -0.214818281986475 0.425587024886319 no 1964 0.414954499335941 2754 25236309 YDL196W YDL196W
SGTC_2217 6934799 96.0675 µM -0.215702127349485 0.425229686952693 no 1965 0.414609971435114 2864 675606
SGTC_2229 7354935 190 µM -0.216234076304604 0.425014650026203 no 1966 0.414402646379048 2865 318112
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.216714665788365 0.424820394014475 no 1967 0.414215358981461 2984 1273210
SGTC_2790 5423970 71.43 µM -0.217099661236853 0.424664790625828 no 1968 0.414065338982108 2953 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1897 st060201 15 µM -0.219815816676569 0.423567338553444 no 1969 0.413007300482951 2818 611878
SGTC_1040 k898-0338 155 µM -0.219862382746296 0.423548528856598 no 1970 0.412989166838717 3012 20969351
SGTC_375 3970-0961 9.27 µM -0.221660812294808 0.422822212693993 no 1971 0.412288969234365 2843 2898222
SGTC_2814 7977482 42.97 µM -0.22275134954807 0.42238191443871 no 1972 0.41186451703486 2961 6456762
SGTC_1462 k081-0014 26.5 µM -0.223953510977019 0.421896660939789 no 1973 0.411396738643096 2827 3270634
SGTC_1590 st077108 57.8 µM -0.225954492814898 0.421089226137949 no 1974 0.410618407229513 2882 5489485
SGTC_1967 st070177 51.4 µM -0.227528473082761 0.420454327667136 no 1975 0.410006415718557 2980 5729214
SGTC_1385 3091-4834 14.1 µM -0.229035199453778 0.419846751277654 no 1976 0.40942077898491 2923 4072814
SGTC_2270 7924575 90.91 µM -0.229408975398682 0.419696058372892 no 1977 0.409275530405018 3006 1262135
SGTC_1232 0279-0259 161 µM -0.230754252099713 0.419153789206239 no 1978 0.408752861801765 2832 1560000
SGTC_3274 9138298 49.47 µM -0.232572245967622 0.418421216039786 no 1979 0.408046790442563 2793 17015756
SGTC_1784 st039334 36.3 µM -0.233104703563804 0.418206712022268 no 1980 0.407840051295231 3059 3496984
SGTC_1801 st050089 28.441 µM -0.233713157806636 0.417961622043964 no 1981 0.407603836084187 2812 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_3249 9135183 49.47 µM -0.234099973746105 0.417805826211285 no 1982 0.407453683156684 2990 4902779
SGTC_1380 2291-0730 164 µM -0.237549504279331 0.416417050028976 no 1983 0.406115259575784 2921 2999191
SGTC_1707 st032323 6.317 µM -0.238750742844541 0.415933676955183 no 1984 0.405649433605258 2840 3132057 YMR211W DML1
SGTC_2709 st078560 56 µM -0.239463902490878 0.415646764777743 no 1985 0.405372941962832 2980 17250903
SGTC_1988 st071872 53.4 µM -0.240383101444737 0.415277027004709 no 1986 0.405016638647075 2952 16414116
SGTC_2794 7785382 27.27 µM -0.240574495557178 0.415200050231378 no 1987 0.404942459642187 2843 2205081
SGTC_1634 st006576 41 µM -0.242145208373079 0.414568448674471 no 1988 0.40433382454831 3008 3915356
SGTC_2644 guaiazulene 100 µM -0.242377495533362 0.414475062058565 no 1989 0.404243835268549 2923 3515 A coloring agent.
SGTC_1489 4065-0444 182 µM -0.242425948590636 0.414455583041566 no 1990 0.404225064935254 2945 2877968
SGTC_2823 7987624 58.44 µM -0.243229556573527 0.414132548620135 no 1991 0.403913785706951 3054 2239440
SGTC_1848 st056003 16.4 µM -0.24354473573825 0.414005868711939 no 1992 0.40379171699908 2837 146492
SGTC_369 0957-0393 4.5 µM -0.243967200224246 0.413836081668989 no 1993 0.403628111447037 2900 6997992
SGTC_3221 9128209 49.47 µM -0.244056025218086 0.413800385253587 no 1994 0.403593714813218 2873 16460723
SGTC_1161 k007-0610 110 µM -0.245201579447135 0.413340081240767 no 1995 0.403150176746029 2929 5843850
SGTC_481 bay k-8644 50 µM -0.245339823107018 0.413284540525896 no 1996 0.403096659691083 2845 2303 A calcium channel antagonist.
SGTC_416 estradiol valerate 100 µM -0.246729793818328 0.412726203092549 no 1997 0.402558673559242 2891 13791 A steroid.
SGTC_2529 gangaleoidin 93.61 µM -0.246887517599168 0.41266285814694 no 1998 0.40249763843595 2832 4565183
SGTC_2446 5162541 200 µM -0.247168799809263 0.412549895373128 no 1999 0.402388795217947 2810 1549321
SGTC_1526 st051518 75 µM -0.247836285349404 0.412281862567319 no 2000 0.402130539455187 2898 673993
SGTC_1196 1588-0294 184 µM -0.247913396562189 0.412250900732761 no 2001 0.402100707229746 2899 6144269
SGTC_1889 st059080 5.18 µM -0.248172380786192 0.412146916913951 no 2002 0.402000517470978 2996 176925 Isolated from Daphnopsis sellowiana.
SGTC_292 k038-0015 474 µM -0.248548632337998 0.41199586050505 no 2003 0.401854973545975 2956 46368540
SGTC_11 0438-0307 1.3 µM -0.248973115895678 0.411825455700952 no 2004 0.401690788561689 2952 4011476
SGTC_556 4058-0063 51.5 µM -0.250249390678426 0.411313207851238 no 2005 0.401197245900176 2892 6615692
SGTC_879 0831-1030 162 µM -0.251816479714569 0.410684445114249 no 2006 0.400591459369817 2874 1549252
SGTC_616 4092-0450 108 µM -0.251840852221846 0.410674667947248 no 2007 0.400582039621462 2907 787165
SGTC_3066 9117245 49.47 µM -0.252016229251033 0.410604316112497 no 2008 0.400514259728994 2893 17176980
SGTC_2343 7990716 14.84 µM -0.253722137136597 0.409920147971345 no 2009 0.399855115300511 2844 6456862
SGTC_2321 7390090 138.78 µM -0.25655704940058 0.408783790794531 no 2010 0.398760367478781 2936 649046
SGTC_1932 st074806 40.9 µM -0.257197782855566 0.408527062559916 no 2011 0.398513047739393 3099 17251235
SGTC_2019 4016004 108 µM -0.257304017676366 0.408484500322666 no 2012 0.398472045594162 2935 45595336
SGTC_3351 9150312 21.596 µM -0.257955305625366 0.408223589977964 no 2013 0.398220700520256 2898 4904905
SGTC_2305 7443522 69.23 µM -0.259555881891528 0.40758256140498 no 2014 0.397603185650813 2860 5415886
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.259792248557317 0.407487917805417 no 2015 0.397512015238096 2851 442882
SGTC_2087 5276107 200 µM -0.261498626203013 0.406804827494771 no 2016 0.396854004402605 2837 144405
SGTC_439 amiodarone 34.4 µM -0.26194436322668 0.406626438428342 no 2017 0.396682168230736 2923 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1202 1988-0068 29.6 µM -0.262076200134122 0.406573679497838 no 2018 0.396631347600394 2872 2850480
SGTC_2458 5808907 16.39 µM -0.263038964321968 0.406188448804816 no 2019 0.396260273528187 3034 2731747
SGTC_840 0245-0196 390 µM -0.265286770792722 0.405289388415424 no 2020 0.395394277451258 3015 3827528
SGTC_572 0960-0087 17.7 µM -0.265451138910066 0.405223665259421 no 2021 0.395330972746255 2898 6796365
SGTC_207 4185-0010 4.486 µM -0.26556176779375 0.405179431425148 no 2022 0.395288366714345 2946 3761753
SGTC_621 3584-0052 32.1 µM -0.266041154076344 0.40498776769782 no 2023 0.395103757182203 2968 2273927
SGTC_1224 0823-0416 294 µM -0.266151578159272 0.404943622204191 no 2024 0.395061236692058 3006 3598164
SGTC_3123 9126162 49.47 µM -0.266435738848254 0.4048300256113 no 2025 0.394951821998451 2850 25239884
SGTC_2601 securinine 100 µM -0.267092521238921 0.404567499795216 no 2026 0.394698962840307 2869 442872 A GABA receptor antagonist.
SGTC_2979 9012552 45.46 µM -0.267689100386198 0.404329075349744 no 2027 0.394469320180201 2989 17100905
SGTC_1454 4239-0054 42.6 µM -0.268736580043727 0.403910533317774 no 2028 0.39406620005614 3071 1340767
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.269386136572021 0.403651044872024 no 2029 0.39381627669658 2898 688664
SGTC_1847 st056231 15 µM -0.270814971790296 0.403080395231972 no 2030 0.393266672106846 2880 5393180
SGTC_2 0422-0095 29 µM -0.271215789808837 0.40292035314074 no 2031 0.393112534724563 2908 6790840
SGTC_1998 st075797 76.8 µM -0.271929478661578 0.402635425548613 no 2032 0.392838122159407 2985 24208315
SGTC_1330 1469-0054 61.8 µM -0.272249041471958 0.402507862526225 no 2033 0.392715267868763 3032 7102664
SGTC_410 α-linolenic acid 100 µM -0.272863189050827 0.402262736365602 no 2034 0.392479191986113 2998 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1063 disulfiram 1.84 µM -0.273424840720385 0.402038596660675 no 2035 0.392263329950225 2882 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_137 0438-0332 85.389 µM -0.274926766599272 0.401439377861156 no 2036 0.391686251235978 2943 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2466 5983409 37.09 µM -0.275130035331332 0.401358298123804 no 2037 0.391608168415734 2919 2879657
SGTC_2317 5986382 200 µM -0.275617348566223 0.401163936149607 no 2038 0.39142099168931 2960 877883
SGTC_118 0083-0097 135.343 µM -0.275656921459846 0.401148153810275 no 2039 0.391405792867215 2922 5207356
SGTC_1269 0831-0796 3.05 µM -0.275874799987596 0.401061263057572 no 2040 0.391322114896011 3024 927758
SGTC_2582 agaric acid 100 µM -0.276081733896413 0.400978741589902 no 2041 0.391242644949058 3007 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_548 1436-0017 110 µM -0.276956016820104 0.400630142313974 no 2042 0.390906939502694 3031 9677137
SGTC_557 1315-0110 16.2 µM -0.277678597700854 0.400342090287398 no 2043 0.390629545645989 2877 6833801
SGTC_858 0438-0351 2.77 µM -0.278452531552748 0.400033626859821 no 2044 0.390332499463913 2925 2799119
SGTC_2425 5628681 7.85 µM -0.278583117787997 0.399981585819316 no 2045 0.390282385023826 2982 5714958
SGTC_1700 st030840 7.9285 µM -0.27914406023686 0.399758060047248 no 2046 0.390067135632053 3009 5499307
SGTC_169 k015-0017 16.025 µM -0.279198797654317 0.399736249899885 no 2047 0.390046133149502 3115 1840002
SGTC_1756 st041558 35.5 µM -0.279210482555816 0.399731594086407 no 2048 0.390041649750836 3092 3955792
SGTC_1404 3909-7820 48.3 µM -0.279335455776192 0.399681799778425 no 2049 0.389993699489672 2996 23741373
SGTC_1961 st076550 68.7 µM -0.280730501144787 0.399126069079426 no 2050 0.389458556290241 3014 1579337
SGTC_74 000s-0487 160.283 µM -0.281520367399446 0.398811508264119 no 2051 0.38915565429014 2861 677548
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.282744857358658 0.398323990408843 no 2052 0.388686213733709 3123 6728940
SGTC_3194 9111903 49.47 µM -0.283777372419888 0.397913028610381 no 2053 0.388290498079579 3112 17087251
SGTC_2486 5283202 22.39 µM -0.283874948349796 0.397874197273828 no 2054 0.388253107691619 2954 1377751
SGTC_2429 5902844 64.44 µM -0.284774642366182 0.397516202580113 no 2055 0.387908400317935 3066 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2878 9043973 25.97 µM -0.285254349235235 0.39732535903588 no 2056 0.387724642248125 3052 6465167
SGTC_2212 7123476 200 µM -0.288541469546653 0.396018295399063 no 2057 0.386466145760536 2938 1085715
SGTC_456 gingerol 170 µM -0.290951559246054 0.395060708385307 no 2058 0.385544183796222 3100 442793 A herb.
SGTC_2606 farnesol 9.78 µM -0.291035864337846 0.395027223363888 no 2059 0.38551194517791 3097 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1813 st051246 8.6015 µM -0.291153113234322 0.394980654727713 no 2060 0.385467110026514 3010 5291959
SGTC_1159 4092-0538 61.2 µM -0.291974938304026 0.394654286357029 no 2061 0.385152892906391 2935 717301
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.292819518452657 0.394318958366072 no 2062 0.384830054144826 3049 16725076
SGTC_489 paxilline 115 µM -0.295556223244046 0.393232929592132 no 2063 0.383784504737558 2994 105008 A toxic potassium channel blocker.
SGTC_2522 biochanin a 4.94 µM -0.296107567951106 0.393014235215819 no 2064 0.383573967315103 3053 5280373 A possible chelator.
SGTC_2156 5649887 115 µM -0.298007001037758 0.392261071948553 no 2065 0.382848910106772 3039 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3120 9124077 49.47 µM -0.299014263526317 0.391861835699938 no 2066 0.382464581223779 2942 18774327 YGL155W CDC43
SGTC_2120 5538279 151.968 µM -0.300058289102173 0.391448148267343 no 2067 0.382066347252088 2966 2058197
SGTC_1671 st016596 74.5 µM -0.300107334212445 0.391428717519163 no 2068 0.382047642509385 2977 2829167
SGTC_1849 st056239 19.2 µM -0.300548215104635 0.391254060989441 no 2069 0.38187951245275 2922 5393181
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.301167387526933 0.39100881066285 no 2070 0.381643428487286 3117 23847180
SGTC_2247 cerulenin 830 nM -0.301218391379017 0.390988610286482 no 2071 0.381623983213466 3159 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2351 9026858 72.31 µM -0.301645343666932 0.390819524855899 no 2072 0.381461218913215 2908 1409300
SGTC_1817 st052116 64.4 µM -0.301769741720243 0.390770263517393 no 2073 0.381413799378096 3068 4361398
SGTC_1522 st012842 45.6 µM -0.304560172101976 0.389665721670935 no 2074 0.380350578867885 2860 3491067 YOR116C RPO31
SGTC_2164 5685496 200 µM -0.304670619648643 0.389622021253602 no 2075 0.380308514251807 3054 759046
SGTC_2279 7948423 32.93 µM -0.304981153343377 0.389499160887885 no 2076 0.380190253202202 3142 1247112
SGTC_71 0417-1750 47.813 µM -0.306584936394749 0.388864812007678 no 2077 0.379579660420304 3155 6811472
SGTC_981 1488-1094 54.9 µM -0.306668894666299 0.388831611897193 no 2078 0.37954770405647 2895 3449522
SGTC_1470 k295-0292 231 µM -0.30772259468857 0.388415010240874 no 2079 0.379146712692089 3054 5045612
SGTC_2160 5660466 132.927 µM -0.308518350048101 0.388100477261587 no 2080 0.378843969731226 3009 2859134
SGTC_8 0354-0001 70 µM -0.308992203753017 0.387913215076688 no 2081 0.378663728670269 2972 4993152
SGTC_3199 9111318 49.47 µM -0.309006419158212 0.387907597694989 no 2082 0.378658321924292 3068 8548020
SGTC_3205 9113483 49.47 µM -0.309205376609593 0.387828979820134 no 2083 0.378582652117534 3131 17018033
SGTC_3337 9144342 33.5465 µM -0.309962673273246 0.387529776744404 no 2084 0.37829467086534 3039 17682949
SGTC_611 3453-1652 23.7 µM -0.310145830050538 0.387457422694067 no 2085 0.378225031002966 3058 1560575
SGTC_1679 SEC14.276 6.7 µM -0.310960709784266 0.387135560921205 no 2086 0.377915245444434 3083 1005053 YMR079W SEC14
SGTC_1726 st035556 14.5795 µM -0.312620660552137 0.386480152597906 no 2087 0.377284439757507 3162 5919439
SGTC_2827 7993847 71.43 µM -0.312805039834464 0.386407372960814 no 2088 0.377214393086035 3048 2985692
SGTC_334 1502-1024 68.5 µM -0.31302797995124 0.386319377625737 no 2089 0.377129702343836 3043 3296216
SGTC_2930 9013230 14.89 µM -0.315123608800177 0.385492511087747 no 2090 0.376333901901823 3092 2995857
SGTC_1164 k060-0068 93.7 µM -0.317112638297813 0.38470818622194 no 2091 0.375579067723674 2972 5963676
SGTC_1868 st057644 42.7 µM -0.318303112728452 0.384238977304795 no 2092 0.375127511697342 2941 688665
SGTC_2892 9047358 58.44 µM -0.318907520494109 0.384000823264092 no 2093 0.374898320665018 3007 6466771
SGTC_934 2950-0684 338 µM -0.319491962988399 0.383770577762879 no 2094 0.374676742457598 3174 1121253
SGTC_775 4577-0580 57.3 µM -0.31990128665731 0.383609346059598 no 2095 0.374521581237787 3162 2006902
SGTC_515 4092-1064 102 µM -0.321073385980875 0.383147770236243 no 2096 0.374077389166146 3196 717353
SGTC_336 4111-0029 111 µM -0.322687311493638 0.382512473605558 no 2097 0.373466031242676 2999 3131175
SGTC_3215 9129942 49.47 µM -0.324328041531939 0.381866949752024 no 2098 0.372844846006071 3113 17682944
SGTC_1282 0886-0010 32.4 µM -0.324925082246999 0.381632133242655 no 2099 0.372618886555333 3153 2836211 YNL267W PIK1
SGTC_1156 4092-0367 4.88 µM -0.325649362842452 0.381347331676391 no 2100 0.372344830014431 3014 1357585
SGTC_2207 7258803 200 µM -0.326079740450268 0.38117812904066 no 2101 0.372182012409204 3055 3666799
SGTC_1660 st012960 28.1 µM -0.326755754848942 0.380912400351918 no 2102 0.371926313260652 3071 24207266
SGTC_665 3914-0008 307 µM -0.327885515692266 0.380468437774096 no 2103 0.371499112842526 2981 1069549
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.327904116118547 0.380461129672441 no 2104 0.371492080720871 2975 6708784 An antioxidant flavonoid
SGTC_3190 9110366 49.47 µM -0.32868271555502 0.380155256498253 no 2105 0.371197760055287 3093 17123768
SGTC_1002 4049-0206 172 µM -0.3292429207809 0.379935225941391 no 2106 0.370986041805854 2976 4662749
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.329374081018841 0.37988371603893 no 2107 0.370936478082216 3109 521171
SGTC_1771 st048882 4.1505 µM -0.329883385841148 0.379683719521018 no 2108 0.370744038815079 2979 4580403
SGTC_216 k038-0035 28.382 µM -0.330277967616646 0.379528795179015 no 2109 0.370594969523468 3076 4444231 YPR107C YTH1
SGTC_357 1325-0123 420 µM -0.332546269417741 0.378638569423052 no 2110 0.369738403838272 3116 1098503
SGTC_2945 9067681 61.76 µM -0.333016426963569 0.378454130097205 no 2111 0.369560941645426 2990 16456930
SGTC_1513 0337-0559 19 µM -0.334100191518408 0.37802908281235 no 2112 0.369151977777957 3010 775073
SGTC_2772 vinpocetine 57.06 µM -0.334236417439164 0.377975666088403 no 2113 0.369100582724696 3190 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2987 9018338 71.43 µM -0.335402053928007 0.377518693763151 no 2114 0.368660909396434 3107 5055682
SGTC_1111 tnp00062 510.699 nM -0.337281002785785 0.376782437862096 no 2115 0.36795253957375 3150 676306
SGTC_122 0236-0016 402.397 µM -0.339068707476924 0.376082351212845 no 2116 0.367278985679991 3049 6808838
SGTC_1876 myriocin 605 nM -0.340909716499874 0.375361815934993 no 2117 0.366585774911561 3187 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1477 0139-0234 16 µM -0.341124254912264 0.375277877981523 no 2118 0.366505021196022 3035 620880
SGTC_2339 9000433 200 µM -0.342172820698905 0.374867712626095 no 2119 0.366110419000856 3050 2988954
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.342766658502282 0.374635485023345 no 2120 0.365887005366403 3109 688664
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.345082825011665 0.373730154672526 no 2121 0.365016052477334 3073 66535 A nucleotide analog.
SGTC_1147 3809-1045 12.3 µM -0.346160548057347 0.373309137304411 no 2122 0.364611031017646 3032 325925
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.34858121304185 0.37236404550547 no 2123 0.363701866962895 3029 229346 A bile salt which induces apoptosis.
SGTC_2168 5727979 200 µM -0.348910572811639 0.372235513960796 no 2124 0.363578223726558 3008 695210
SGTC_1713 st033146 12.748 µM -0.349073743364851 0.37217184247118 no 2125 0.363516973981009 3173 674619
SGTC_1378 2093-0007 380 nM -0.349401538731509 0.372043942582458 no 2126 0.363393939145665 3131 3618014
SGTC_1174 0739-0097 51.1 µM -0.34958671904378 0.371971694776191 no 2127 0.363324439725902 3054 728447
SGTC_2799 7812892 81.82 µM -0.350117481501995 0.371764643624605 no 2128 0.363125265931236 3174 20205235
SGTC_1406 3909-7906 11.9 µM -0.351294436666021 0.371305644203031 no 2129 0.362683734109257 3061 X1406
SGTC_418 lividomycin a 100 µM -0.351492035204375 0.371228600891935 no 2130 0.362609623384861 3165 72394 An antibiotic.
SGTC_1856 st057054 55.7 µM -0.352061961104949 0.371006416732968 no 2131 0.362395897500423 3238 1266018
SGTC_1190 1486-1332 13 µM -0.352563892960854 0.370810775482717 no 2132 0.36220770533005 3076 4150046
SGTC_76 0433-0009 400.328 µM -0.353128795111794 0.370590629833706 no 2133 0.361995943178991 3119 2841569
SGTC_2062 5245942 200 µM -0.354638714995655 0.370002413422517 no 2134 0.361430134273149 3031 1376160
SGTC_2683 piperine 63.03 µM -0.354982328876572 0.369868594872244 no 2135 0.361301414878859 3045 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2091 4-phenylthiadiazole 200 µM -0.355674641816966 0.369599025243678 no 2136 0.361042118853911 3029 270010
SGTC_2301 7769476 200 µM -0.35700368211152 0.36908170933854 no 2137 0.360544524606308 3093 977820
SGTC_1903 st060211 78.3 µM -0.357514348678518 0.368883000369468 no 2138 0.360353393173413 3193 688960
SGTC_145 3737-0113 38.366 µM -0.35768924142036 0.368814954708871 no 2139 0.360287942627971 3165 6849351
SGTC_1303 1160-0052 261 µM -0.35783217046809 0.368759348242035 no 2140 0.360234456975378 3070 3562476
SGTC_709 3807-1509 243 µM -0.359360540417129 0.368164908747072 no 2141 0.35966269500871 3081 1886677 YPL242C IQG1
SGTC_991 3996-0057 64.7 µM -0.361292282169945 0.367414034580544 no 2142 0.358940481287617 3109 715343
SGTC_319 1348-1596 45.5 µM -0.365801096202329 0.365663419970766 no 2143 0.357256750919562 3228 5380505
SGTC_2997 9067075 71.4286 µM -0.368250937543094 0.364713401453526 no 2144 0.35634306603711 3136 27209819
SGTC_2057 5236571 38.335 µM -0.368749607646771 0.364520124782701 no 2145 0.356157184421728 3230 54684039 YBR257W POP4
SGTC_2028 5153890 36.43 µM -0.369710468712765 0.364147807321927 no 2146 0.355799115370182 3054 2830968 YPR165W RHO1
SGTC_2832 7992762 51.95 µM -0.370153130427223 0.363976326478011 no 2147 0.355634198332477 2986 2985177
SGTC_591 4299-0174 154 µM -0.37017812743596 0.363966643804918 no 2148 0.355624886309694 3102 5509088
SGTC_1277 0873-0036 22 µM -0.3705205108058 0.363834029231002 no 2149 0.355497348454095 3163 5965735
SGTC_332 4112-0506 40.9 µM -0.370802789299227 0.363724707207331 no 2150 0.355392211840801 3059 2790355
SGTC_1559 coumarin 343 70.1 µM -0.370984927065481 0.363654174001043 no 2151 0.355324379187118 3216 108770 A hepatotoxic, DNA x-linker.
SGTC_2805 7950783 58.44 µM -0.372584858003797 0.363034796427929 no 2152 0.354728722117174 3169 1178958 YDL195W SEC31
SGTC_2641 levomentholum 100 µM -0.373011060590516 0.362869861933372 no 2153 0.354570105973925 3120 16666
SGTC_235 0330-0087 5 mM -0.373515841906326 0.362674551462823 no 2154 0.354382278480556 3090 46494818 YHR062C RPP1
SGTC_147 4466-0538 29.23 µM -0.37367637516439 0.36261244526574 no 2155 0.354322551994403 3274 6742687 YHR072W ERG7
SGTC_3033 9090887 49.47 µM -0.374194820858312 0.362411896628378 no 2156 0.35412968846703 3068 19325384
SGTC_2030 5175110 200 µM -0.374363899892554 0.362346500504202 no 2157 0.354066798590215 3186 2831986
SGTC_3319 9138450 16.7555 µM -0.374784044661525 0.36218401496408 no 2158 0.353910540671043 3050 2029690
SGTC_734 2023-0417 80 µM -0.375251877404737 0.362003115936562 no 2159 0.353736575855517 3151 3935732
SGTC_1257 0669-0121 16 µM -0.375636559529017 0.361854392229949 no 2160 0.353593553689846 3128 4307855
SGTC_2470 5664817 21.68 µM -0.377297049255077 0.361212662362335 no 2161 0.352976432393973 3091 2859561
SGTC_1214 0358-0031 63.7 µM -0.377650730022687 0.361076025637848 no 2162 0.3528450367554 3299 4301366
SGTC_2076 5212012 200 µM -0.38010183908381 0.360129581902228 no 2163 0.351934910336236 3088 604802
SGTC_1810 st050138 53 µM -0.380497501598238 0.35997688537539 no 2164 0.351788075388244 3206 3444541
SGTC_2586 curcumin 80 µM -0.380513140067566 0.359970850539324 no 2165 0.351782272224868 3173 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_14 0354-0009 295 µM -0.380760795889095 0.359875285591655 no 2166 0.351690376070767 3077 1713507
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.382453591254563 0.359222307828826 no 2167 0.351062472978074 3072 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1435 4092-0789 56.7 µM -0.382807829300723 0.359085716218149 no 2168 0.35093112797586 3166 2248285
SGTC_275 trichlorophene 5.69 µM -0.383061333029152 0.358987978082856 no 2169 0.350837144352406 3160 62616
SGTC_2713 st079149 53.4 µM -0.383285929835177 0.358901392696777 no 2170 0.350753885265863 3147 3103253
SGTC_358 0075-0058 9.45 µM -0.383552588160165 0.358798601386886 no 2171 0.35065504308382 3299 1069125
SGTC_3201 9113999 49.47 µM -0.384220070786277 0.358541345384796 no 2172 0.350407671781627 3239 16649224
SGTC_2047 4141938 200 µM -0.384314184158877 0.358505078094827 no 2173 0.35037279815007 3112 3807862
SGTC_9 0092-0002 10.449 µM -0.384819217954378 0.358310481360614 no 2174 0.350185679850889 3160 759368
SGTC_929 2805-0021 398 µM -0.385278852620187 0.358133409539083 no 2175 0.350015413828988 3160 3098024
SGTC_2913 7966556 36.57 µM -0.385436771626172 0.358072579118428 no 2176 0.349956921628201 3213 2976516
SGTC_139 0099-0334 718.624 µM -0.387925524286872 0.357114388013625 no 2177 0.349035574363776 3067 97690
SGTC_2313 7726885 200 µM -0.388851458184224 0.356758125029226 no 2178 0.348693016196979 3160 726423
SGTC_3220 9131269 49.47 µM -0.388941244133335 0.35672358556222 no 2179 0.348659805574634 3156 17722206
SGTC_1011 4112-3381 17.4 µM -0.389245526459895 0.356606540913876 no 2180 0.34854726423602 3247 2877139
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.389791673799266 0.356396494811445 no 2181 0.348345300556274 3197 368090
SGTC_537 1334-0398 209 µM -0.390070392165259 0.356289317614004 no 2182 0.348242247889039 3236 5846986
SGTC_1800 st050079 29.0735 µM -0.391112423316767 0.35588871991285 no 2183 0.347857069058134 3187 3645560
SGTC_1186 1319-0216 26 µM -0.391599637244133 0.355701470290094 no 2184 0.347677027988457 3237 4565136
SGTC_2073 5212005 126 µM -0.391915911410615 0.355579936119377 no 2185 0.347560172989707 3105 691789
SGTC_2508 celastrol 40.54 µM -0.393097603953239 0.355125978996939 no 2186 0.347123696860022 3136 122724 Celastrol is a natural product and antioxidant.
SGTC_3313 9133968 57.047 µM -0.393672012298871 0.354905389401538 no 2187 0.346911603575658 3158 1494643
SGTC_2459 5811157 9.22 µM -0.394151253243296 0.354721384079149 no 2188 0.34673468638779 3127 2870684 YBR192W RIM2
SGTC_686 1319-0111 510 µM -0.39467894283994 0.354518816023088 no 2189 0.34653992248932 3247 4562600
SGTC_330 1488-0319 80.1 µM -0.394724906822679 0.354501173440675 no 2190 0.346522959654431 3172 6846614
SGTC_550 4123-0385 25.7 µM -0.39623025680781 0.353923540251518 no 2191 0.345967586173138 3096 5731123
SGTC_2376 9072922 81.32 µM -0.396686502127095 0.353748536009996 no 2192 0.345799327505789 3230 17087968
SGTC_3243 9134147 49.47 µM -0.397810086576936 0.353317689065823 no 2193 0.345385090795522 3183 24282180
SGTC_3046 9092212 49.47 µM -0.398439721672987 0.353076332852269 no 2194 0.345153041420542 3166 25236637
SGTC_1292 0kpi-0043 232 µM -0.398946309204188 0.352882187003801 no 2195 0.344966382961985 3145 3333905
SGTC_2766 oltipraz 83.91 µM -0.400576902117003 0.352257534840968 no 2196 0.344365827089246 3236 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2302 7771753 200 µM -0.402337524753219 0.351583517791956 no 2197 0.343717820926063 3174 2203047
SGTC_2034 5197015 53.07 µM -0.402351621174617 0.351578123154906 no 2198 0.343712634515494 3256 780676
SGTC_2373 9071805 200 µM -0.403572736847188 0.351110921232927 no 2199 0.343263468591149 3270 10149009
SGTC_69 0096-0274 206.684 µM -0.40604004400624 0.350167610382359 no 2200 0.342356588929708 3389 6741392
SGTC_1054 3429-0080 167 µM -0.40613090134266 0.350132891036623 no 2201 0.342323210852761 3270 1162877
SGTC_2354 9060492 162 µM -0.407475066647991 0.349619391162528 no 2202 0.341829551564857 3259 6471895
SGTC_3067 9117431 49.47 µM -0.40812515620306 0.349371141668513 no 2203 0.341590896058267 3129 17150885
SGTC_1387 3342-1166 1.8 µM -0.408229680836293 0.349331232888643 no 2204 0.341552529744372 3162 3418228
SGTC_426 0988-0037 14.6 µM -0.408488438408097 0.349232443258426 no 2205 0.341457558466201 3290 5383008
SGTC_1922 5578187 25 µM -0.408956069925274 0.349053934707326 no 2206 0.341285950064295 3312 1350412
SGTC_3334 9142812 21.919 µM -0.409804117646199 0.34873029544778 no 2207 0.340974822712351 3227 45283678
SGTC_1641 st009299 47.1 µM -0.40987056472344 0.348704941989159 no 2208 0.340950449517826 3214 4046054
SGTC_1084 voriconazole 435 nM -0.411233177385788 0.348185174449101 no 2209 0.340450781359799 3236 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1655 st012546 55.1 µM -0.411420776764397 0.348113637112714 no 2210 0.340382010834019 3194 720985 YLR208W SEC13
SGTC_1154 4088-0362 150 µM -0.411467755187354 0.34809572366038 no 2211 0.340364790228106 3101 6618304
SGTC_967 1306-0166 352 µM -0.411945810663312 0.347913454488869 no 2212 0.340189571160564 3270 4437607
SGTC_1120 ficusin 1.78878 µM -0.412482492163763 0.347708874720929 no 2213 0.339992905326817 3248 6199 A DNA cross-linker.
SGTC_88 0180-0332 8.668 µM -0.412935512504332 0.347536220590383 no 2214 0.339826930832843 3110 3101745
SGTC_166 k072-0058 166.424 µM -0.414098826159015 0.347093005949981 no 2215 0.339400866220888 3283 5846229
SGTC_1814 st052110 31.539 µM -0.414595248215007 0.346903936111818 no 2216 0.339219113659558 3264 674163
SGTC_3150 9097574 49.47 µM -0.414739539680172 0.346848987674823 no 2217 0.339166291950646 3274 17217476
SGTC_1364 1653-0028 37.6 µM -0.416251393258023 0.346273444159348 no 2218 0.338613028185757 3184 5718652
SGTC_1076 itraconazole 331 nM -0.418810187527328 0.345300152577521 no 2219 0.337677429435396 3207 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2165 5727197 32.143 µM -0.420479816749617 0.344665624389724 no 2220 0.337067485364831 3451 1361712
SGTC_1065 prochlorperazine maleate 2.48 µM -0.420649842144323 0.344601032178789 no 2221 0.337005396175779 3229 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2777 climbazole 1.536 µM -0.42123347159114 0.344379347327144 no 2222 0.336792302515551 3212 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_3247 9135149 49.47 µM -0.421737393129974 0.344187981592109 no 2223 0.336608353790185 3165 8934436 YOR116C RPO31
SGTC_855 0428-0020 25 µM -0.421780432241138 0.344171639207265 no 2224 0.336592644842901 3161 6812414
SGTC_2681 menadione 3.18 µM -0.421897588033804 0.344127155444793 no 2225 0.336549885316883 3240 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2427 5545055 42.75 µM -0.422864701285112 0.34376002739392 no 2226 0.33619698906002 3138 5372858
SGTC_104 0074-0074 590.992 µM -0.422938350824727 0.343732075156695 no 2227 0.336170120508663 3161 3943124
SGTC_2421 5690543 90.72 µM -0.423138169688444 0.343656242132295 no 2228 0.336097227549272 3240 3397993
SGTC_1748 st037455 53.6035 µM -0.423177992089506 0.343641129930941 no 2229 0.336082701265524 3307 580690
SGTC_339 3091-4833 71.4 µM -0.424251362919217 0.343233890688669 no 2230 0.335691252888527 3157 3240077
SGTC_1425 4048-4433 7.33 µM -0.424577983165866 0.343110006342591 no 2231 0.335572172865847 3247 23734946
SGTC_414 piperonyl butoxide 100 µM -0.426844666238458 0.342250737443403 no 2232 0.334746235397971 3142 5794 A potent inhibitor of cytochrome P450.
SGTC_197 4544-0043 41.561 µM -0.426867554453234 0.342242064985317 no 2233 0.334737899422548 3189 896523
SGTC_1946 st076057 65.1 µM -0.427255870057649 0.342094942960247 no 2234 0.334596485808242 3174 953009
SGTC_1821 st053465 65.6 µM -0.427739993534096 0.341911555556667 no 2235 0.334420214521759 3208 675086
SGTC_2233 sulbentine 40.3845 µM -0.428726957915856 0.341537806082103 no 2236 0.334060969944513 3208 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_828 2074-0507 139 µM -0.429139255640784 0.341381720729947 no 2237 0.333910942929545 3290 X828
SGTC_2036 5160441 105 µM -0.429179504584733 0.341366484964267 no 2238 0.333896298553908 3192 134534 YIL048W NEO1
SGTC_1952 st077036 64.1 µM -0.430483350033358 0.340873069531136 no 2239 0.333422037889446 3220 2937007
SGTC_849 0386-0493 241 µM -0.431517632998576 0.340481858343737 no 2240 0.333046017113499 3144 726119
SGTC_1268 0828-0275 2.46 µM -0.431571679867387 0.340461420160744 no 2241 0.333026372607967 3257 745337
SGTC_2884 9058502 51.95 µM -0.431833524080971 0.340362408663979 no 2242 0.33293120614324 3259 6471554
SGTC_338 4055-0136 114 µM -0.433331179256349 0.339796309973814 no 2243 0.332387094967624 3147 2900563
SGTC_1562 morin hydrate 59.1 µM -0.43406327103518 0.339519717922189 no 2244 0.332121248037062 3320 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1669 st015249 58.4 µM -0.434534910868959 0.339341573141323 no 2245 0.331950024619471 3274 722793
SGTC_2431 5490079 200 µM -0.436273560584825 0.338685171860184 no 2246 0.331319131158918 3217 5722345
SGTC_2571 chrysanthemic acid 100 µM -0.436535039942344 0.338586496537055 no 2247 0.33122429104622 3187 2743 An insecticide.
SGTC_254 nsc-64875 3.808 µM -0.43694825274545 0.338430583657258 no 2248 0.33107443838539 3314 56993
SGTC_1100 amiodarone 5.07 µM -0.437057977196111 0.338389187232376 no 2249 0.331034651082672 3259 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1478 0453-0656 35.7 µM -0.438355322445432 0.337899877920396 no 2250 0.330564364060382 3257 5258496
SGTC_758 0868-0029 16 µM -0.439222194906885 0.337573079113904 no 2251 0.33025027219224 3271 762687
SGTC_3057 9095946 49.47 µM -0.440711199545175 0.337012031080764 no 2252 0.329711043811736 3202 24540043
SGTC_2973 9094665 17.96 µM -0.442078664131505 0.336497097779758 no 2253 0.329216141546828 3357 25237061 YIL048W NEO1
SGTC_1762 st045503 25.4615 µM -0.442170284844554 0.336462607972832 no 2254 0.32918299356575 3249 4645554
SGTC_59 0330-0160 1.33 µM -0.442763412560143 0.336239363588678 no 2255 0.328968434997468 3277 4293482
SGTC_1067 clotrimazole 1.36 µM -0.443042948728274 0.336134170376094 no 2256 0.328867334854751 3187 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2818 7996756 12.99 µM -0.44309010300737 0.336116426852416 no 2257 0.32885028175052 3113 2241621
SGTC_1718 roemerine 11.9335 µM -0.443728276682131 0.335876326570621 no 2258 0.328619524553603 3254 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1840 st055363 71 µM -0.443791824261749 0.335852421709508 no 2259 0.328596549962144 3222 676033
SGTC_1006 4099-6547 255 µM -0.443805324185253 0.335847343493096 no 2260 0.328591669368316 3292 3146833
SGTC_2689 tacrolimus 100 µM -0.444882232132942 0.335442343627348 no 2261 0.328202431776175 3242 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_588 3970-1144 52.9 µM -0.444976527776487 0.335406890338061 no 2262 0.328168358432074 3258 1888707
SGTC_1864 st057645 30.4 µM -0.447450704077892 0.334477173763362 no 2263 0.327274836590652 3293 688666
SGTC_2953 9074162 66.49 µM -0.447630094285881 0.334409804008323 no 2264 0.327210090156542 3281 16451992
SGTC_986 1493-0483 84 µM -0.44788557587063 0.334313867442947 no 2265 0.327117889407292 3294 40079
SGTC_3354 9151612 71.43 µM -0.451131485716998 0.333095931201572 no 2266 0.325947393101538 3305 27261949
SGTC_3349 9149703 23.001 µM -0.451261739513741 0.333047093744403 no 2267 0.325900458409492 3233 4910494
SGTC_2821 7996764 71.43 µM -0.452508946033012 0.332579608644621 no 2268 0.325451188977705 3422 2987135
SGTC_3321 9137793 26.8275 µM -0.458821669628021 0.33021744226924 no 2269 0.323181116113601 3285 4904192
SGTC_2197 6588183 93.1375 µM -0.459381373836269 0.330008330284551 no 2270 0.322980160752867 3206 884136
SGTC_853 0419-0306 21 µM -0.459466057396573 0.329976696147592 no 2271 0.322949760592583 3191 762713
SGTC_3227 9130768 49.47 µM -0.4606147626046 0.329547709450481 no 2272 0.322537509127617 3264 17720899
SGTC_3284 9108171 64.8615 µM -0.461675517543637 0.32915176707718 no 2273 0.322157015225948 3256 8687505
SGTC_738 1315-0003 72.4 µM -0.461719022982018 0.329135532119468 no 2274 0.322141413754513 3341 6251474
SGTC_2449 5812982 45.77 µM -0.462002616009744 0.329029711390209 no 2275 0.322039722229606 3297 776185
SGTC_3022 9087993 49.47 µM -0.462538656866076 0.328829728968907 no 2276 0.321847543702363 3303 17173644
SGTC_1775 st081588 35.1725 µM -0.462839648249851 0.328717458658374 no 2277 0.321739654750259 3320 1426443 YGL099W LSG1
SGTC_2374 9071832 200 µM -0.464258315573907 0.328188501532896 no 2278 0.321231342574841 3329 17381698
SGTC_716 1683-5115 658 µM -0.464529646728387 0.328087373562943 no 2279 0.321134162021139 3329 723597
SGTC_2182 6325192 200 µM -0.466911484962106 0.327200178933726 no 2280 0.320281603976314 3312 736248
SGTC_761 k216-0224 480 µM -0.467325800774227 0.327045952725887 no 2281 0.320133399923091 3380 1340404
SGTC_648 0375-0473 33.3 µM -0.468934159248248 0.326447532397289 no 2282 0.319558349401808 3234 1713139
SGTC_837 0091-0265 12.5 µM -0.469334889942232 0.326298502335703 no 2283 0.319415140061773 3205 759367
SGTC_2762 leflunomide 42.06 µM -0.46970542263859 0.326160727454909 no 2284 0.319282746559756 3252 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_620 0109-0052 432 µM -0.47209178966524 0.325273975561279 no 2285 0.318430636284587 3366 493037
SGTC_442 cape 100 µM -0.472734348572661 0.325035375318367 no 2286 0.318201358822087 3330 5281787
SGTC_2480 5767542 37.17 µM -0.475786198566062 0.323903118212594 no 2287 0.317113351667394 3230 2867358
SGTC_1157 4092-0394 27.6 µM -0.477365964509708 0.323317652852564 no 2288 0.316550772996427 3423 3659885
SGTC_2162 5663267 200 µM -0.478210179378212 0.323004963801245 no 2289 0.31625030904982 3373 6456493
SGTC_2517 totarol 10 µM -0.47858608479947 0.322865772279991 no 2290 0.316116559817192 3303 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_3161 9100388 49.47 µM -0.479938164270072 0.322365324968344 no 2291 0.315635681455889 3272 25236368
SGTC_1381 2324-0066 62.1 µM -0.483852259755022 0.320918411092457 no 2292 0.314245361724276 3304 10885928
SGTC_1799 st045822 46.1415 µM -0.484348254101074 0.320735251518149 no 2293 0.314069367802841 3356 3674992
SGTC_2377 9073351 62.6 µM -0.4852559843259 0.320400160145704 no 2294 0.313747386937823 3235 7337946 YHR072W ERG7
SGTC_1109 tnp00067 928.257 nM -0.485695864640968 0.320237829623588 no 2295 0.313591408043903 3290 676295
SGTC_2962 9082311 13.18 µM -0.486554047058429 0.319921230695926 no 2296 0.313287197697326 3218 16459453
SGTC_2029 5175081 200 µM -0.487071942504161 0.319730233176147 no 2297 0.313103674441907 3277 1380876
SGTC_2781 5567276 71.43 µM -0.48841738244805 0.319234264414959 no 2298 0.312627116022899 3378 2853274
SGTC_2521 angolensin 13.4 µM -0.489500334496917 0.31883529122164 no 2299 0.312243758889923 3369 821428 A flavenoid.
SGTC_2828 7998861 71.43 µM -0.489558303106788 0.318813940768108 no 2300 0.312223244150078 3329 2988188
SGTC_1770 st043884 66.3 µM -0.489654564270195 0.318778488089543 no 2301 0.312189179193605 3314 670149
SGTC_296 1222-0039 74.9 µM -0.490284192763818 0.318546638841047 no 2302 0.311966405504056 3287 5984176
SGTC_951 1171-0579 82.7 µM -0.490512505009022 0.318462584550009 no 2303 0.311885641579835 3324 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2546 rhodinyl acetate 100 µM -0.49052287175629 0.318458768202048 no 2304 0.311881974627205 3374 6708682
SGTC_1441 4106-0040 13 µM -0.4926831185694 0.317663929514311 no 2305 0.311118253789747 3330 2904180
SGTC_194 1486-1323 56.904 µM -0.49273798437259 0.31764375317355 no 2306 0.311098867426671 3306 5178754
SGTC_1987 st072290 61.9 µM -0.493020236591104 0.317539966353247 no 2307 0.310999144299408 3287 54697379
SGTC_95 0471-0001 561.058 µM -0.493458181017887 0.317378958418533 no 2308 0.310844440699891 3283 4015405
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.493692712843764 0.317292748245745 no 2309 0.310761606219806 3361 5024745
SGTC_2727 riluzole 51.77 µM -0.494548943113351 0.316978095781175 no 2310 0.310459275023227 3325 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_3272 9137413 49.47 µM -0.497750403465223 0.315802778236418 no 2311 0.309329988586456 3303 17614870
SGTC_2382 9035899 200 µM -0.499101175811629 0.315307441004512 no 2312 0.308854054632667 3278 6462679
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.499508565323534 0.315158113637322 no 2313 0.308710577087368 3342 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2291 7917025 104.35 µM -0.500921546932159 0.314640423727527 no 2314 0.308213168786374 3227 2964612
SGTC_1112 tnp00069 1.16933 µM -0.502076887705631 0.314217399120811 no 2315 0.307806718626276 3353 145826
SGTC_776 4476-4378 112 µM -0.502166742396336 0.314184509307674 no 2316 0.307775117520092 3365 2892008
SGTC_1745 st081495 74 µM -0.502498229831827 0.314063186616155 no 2317 0.307658548632624 3367 13842402 YBL026W LSM2
SGTC_42 0133-0086 60.653 µM -0.50278473409671 0.313958343719786 no 2318 0.307557813899534 3264 162923 Model of phenazepam hydroxylation.
SGTC_2851 9015922 71.43 µM -0.503765151519205 0.313599685044936 no 2319 0.30721320952272 3406 2996893
SGTC_2516 gossypol 71.55 µM -0.50571979610845 0.312885158083057 no 2320 0.306526684601888 3421 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_477 mead ethanolamide 10 µM -0.505837204899104 0.312842261236793 no 2321 0.306485468982208 3283 16061185
SGTC_1189 1431-2119 7.28 µM -0.506292682457269 0.312675870508248 no 2322 0.306325599612303 3403 3107275
SGTC_544 k015-0020 52.4 µM -0.507335528003599 0.312295051870174 no 2323 0.305959707131278 3327 3008304
SGTC_2614 arthonioic acid 13.39 µM -0.507825331430053 0.312116258220131 no 2324 0.305787921623093 3347 6710684
SGTC_1250 0485-0349 40.2 µM -0.508756623721347 0.311776429322797 no 2325 0.305461413521068 3271 6842794 YDL195W SEC31
SGTC_3110 9122132 49.47 µM -0.508850535038543 0.311742169936223 no 2326 0.305428497094262 3463 918317
SGTC_1942 st076330 65.2 µM -0.509284690413747 0.311583808747427 no 2327 0.30527634372488 3431 24208414
SGTC_667 1498-1044 59 µM -0.510070882778337 0.311297128316293 no 2328 0.30500090168475 3325 6739982
SGTC_3111 9122088 49.47 µM -0.510095375220048 0.311288199127961 no 2329 0.304992322545089 3270 16876704
SGTC_810 3825-7150 143 µM -0.510815970801951 0.311025541926423 no 2330 0.304739962448839 3428 22330411 YGL099W LSG1
SGTC_1827 berberine 7.24 µM -0.513672953581229 0.309985119343344 no 2331 0.30374033226335 3252 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2333 9017922 200 µM -0.515274122769361 0.309402688201321 no 2332 0.30318073952766 3397 3163164
SGTC_1479 0549-0158 134 µM -0.515985683739105 0.309144008774929 no 2333 0.302932204085826 3368 5440202
SGTC_2840 9008771 71.43 µM -0.516405770247038 0.308991335779723 no 2334 0.302785518252943 3323 2992978
SGTC_660 4031-1742 102 µM -0.517811698844989 0.308480616032774 no 2335 0.302294827561947 3330 6738706
SGTC_3345 9148410 3.559 µM -0.518102328450105 0.308375087644238 no 2336 0.302193437877772 3389 4903596
SGTC_1471 k673-0312 37 µM -0.518685198416927 0.308163493718303 no 2337 0.301990142592483 3374 24099884
SGTC_487 nimodipine 119 µM -0.519253795570083 0.307957142532972 no 2338 0.301791884638637 3314 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2108 5365811 200 µM -0.519311862207962 0.3079360728221 no 2339 0.301771641307384 3391 780283
SGTC_2699 st077704 54.6 µM -0.519736229299225 0.307782108758201 no 2340 0.301623715964547 3368 645852
SGTC_2537 larixol 68.93 µM -0.520224415023469 0.307605032596755 no 2341 0.301453585155228 3408 6708759
SGTC_2499 avocadenofuran 51.48 µM -0.520645621314301 0.307452287425506 no 2342 0.301306831132127 3261 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_96 0929-0093 37.281 µM -0.523942894548205 0.306257727924839 no 2343 0.300159129541553 3320 6991579
SGTC_2978 9011784 42.97 µM -0.526408058279693 0.305365973588194 no 2344 0.299302358988785 3368 2994934
SGTC_2715 st079500 56.4 µM -0.527364696397818 0.305020227424815 no 2345 0.298970177328139 3342 28246688
SGTC_1172 0370-0043 85 µM -0.530905142455192 0.303742161976431 no 2346 0.297742257018262 3431 376585
SGTC_948 3448-0295 75.3 µM -0.532680156835292 0.303102300319345 no 2347 0.297127502233165 3418 678569
SGTC_1327 1436-0082 2.18 µM -0.534784816863606 0.302344389512398 no 2348 0.29639933162153 3339 15992205
SGTC_693 4161-2696 114 µM -0.535014715490138 0.302261652060895 no 2349 0.296319840841311 3393 805759
SGTC_1415 3966-0071 78.1 µM -0.535652884270389 0.302032036883714 no 2350 0.296099235987301 3415 2893185
SGTC_1916 st067606 49.2 µM -0.536220773929285 0.30182777425563 no 2351 0.295902988912286 3374 19590279
SGTC_2097 5376186 200 µM -0.536461276718861 0.301741287204712 no 2352 0.295819895759108 3412 742755
SGTC_900 1112-0045 141 µM -0.537723368468 0.30128760998177 no 2353 0.29538402181614 3370 56211 YIL048W NEO1
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.537908688519753 0.301221019867676 no 2354 0.295320044872339 3439 364106
SGTC_32 0928-0142 34.1 µM -0.540346854230399 0.300345544265877 no 2355 0.294478925835645 3415 2244242
SGTC_2822 7994718 71.43 µM -0.540477372765588 0.300298711231443 no 2356 0.294433930713421 3387 1018011
SGTC_1899 st063254 59.6 µM -0.540862256761428 0.300160625275814 no 2357 0.294301263807836 3338 3093813
SGTC_2589 lobaric acid 100 µM -0.541689868189544 0.299863798002293 no 2358 0.294016085304064 3342 73157 A novel microtubule depolymerizer.
SGTC_117 lucigenin 22.078 µM -0.541830330049245 0.299813433796414 no 2359 0.293967697613488 3423 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1561 5-methoxyflavone 52.9 µM -0.542209372592724 0.299677542875577 no 2360 0.293837139668167 3415 94525
SGTC_2812 7970281 58.44 µM -0.542396353753407 0.299610518351307 no 2361 0.293772745495992 3470 2233435
SGTC_3085 9117376 49.47 µM -0.543842626857162 0.299092322658883 no 2362 0.293274886314827 3433 16480349
SGTC_1904 st060225 78 µM -0.543995518574862 0.299037565762707 no 2363 0.29322227835527 3426 66595
SGTC_1308 1187-1617 41.4 µM -0.544616145424414 0.298815340177101 no 2364 0.293008774038599 3396 2882570
SGTC_651 3253-0966 34.4 µM -0.545615915624003 0.298457514029727 no 2365 0.292664990866038 3370 781462
SGTC_430 0958-0115 16.4 µM -0.546584846443006 0.29811091171692 no 2366 0.29233199108202 3334 6833180
SGTC_2682 pyrogallin 40.03 µM -0.547404982007811 0.297817679268848 no 2367 0.292050266656528 3394 822798 An ATP competetive kinase inhibitor.
SGTC_708 3448-5400 146 µM -0.551343418962682 0.296411361149844 no 2368 0.29069913981446 3435 3462195
SGTC_2161 5662504 8.5105 µM -0.552159009578778 0.296120514861066 no 2369 0.290419707728395 3374 2859334
SGTC_2942 9052777 62.25 µM -0.556079496381101 0.294724268420772 no 2370 0.2890782554994 3472 6469503
SGTC_1300 1094-0077 113 µM -0.557073546646089 0.294370729345271 no 2371 0.288738590274462 3403 5532636
SGTC_1824 st053723 68.6 µM -0.557992901108064 0.294043930617705 no 2372 0.288424615845347 3403 675225
SGTC_1757 st041620 31.8375 µM -0.558105734164299 0.294003833924267 no 2373 0.288386092620823 3429 5289815
SGTC_959 1222-0044 107 µM -0.558890273853797 0.293725107465863 no 2374 0.288118303823027 3457 6083612
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.559759024663765 0.293416605753937 no 2375 0.287821908017251 3512 165506
SGTC_3217 9129673 49.47 µM -0.560859442476077 0.293026052516707 no 2376 0.287446680171695 3491 17248312
SGTC_293 4049-0273 38.5 µM -0.561252565189938 0.292886586413996 no 2377 0.287312686663187 3393 1380311
SGTC_2511 berberine 10.47 µM -0.562076829819378 0.292594266400387 no 2378 0.287031837016269 3420 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_872 0588-0139 234 µM -0.562467636243728 0.292455716867652 no 2379 0.286898723963307 3456 2047100
SGTC_1473 k844-0725 134 µM -0.563147205586196 0.292214867135234 no 2380 0.286667324699156 3528 54682906
SGTC_1956 st077085 54 µM -0.563933923171826 0.291936157740443 no 2381 0.286399551111813 3426 24208685
SGTC_3015 9080845 49.47 µM -0.564207770998091 0.29183917108822 no 2382 0.286306369903118 3483 5296973
SGTC_1356 1502-0781 85.8 µM -0.564645880231236 0.29168404041576 no 2383 0.286157326000553 3395 567702
SGTC_1426 4048-4480 71.7 µM -0.564649979073967 0.291682589232661 no 2384 0.286155931756323 3475 14224343
SGTC_1818 st052136 56.3 µM -0.564848891428741 0.291612168948711 no 2385 0.286088274487063 3442 674169
SGTC_2132 5317594 122.667 µM -0.565133891855419 0.291511285005716 no 2386 0.285991348806453 3404 794577
SGTC_2082 5219693 150 µM -0.565236157711637 0.291475089088889 no 2387 0.285956573057791 3450 2834649
SGTC_47 0149-0135 24.25 µM -0.565924855559755 0.291231386391365 no 2388 0.285722432072165 3379 5239155
SGTC_800 3448-7362 155 µM -0.566968646788813 0.290862211753127 no 2389 0.285367741688127 3502 15991913
SGTC_600 1495-0418 41.6 µM -0.568972926477427 0.290153939490419 no 2390 0.284687256562519 3430 5377768
SGTC_316 k060-0003 58.6 µM -0.569153333974208 0.290090226763173 no 2391 0.284626043340883 3494 6152314
SGTC_2695 st077686 51.995 µM -0.570702543999798 0.289543377719215 no 2392 0.284100647011689 3427 2876092
SGTC_3329 9141233 27.5565 µM -0.572775622324987 0.288812368826707 no 2393 0.283398313448878 3506 4909101 YNL103W MET4
SGTC_1443 4112-3303 14 µM -0.573971155103418 0.28839119541606 no 2394 0.282993660367806 3464 704433
SGTC_1754 st042065 16.137 µM -0.574545844974061 0.288188841418349 no 2395 0.282799243319539 3469 1126236 YIL048W NEO1
SGTC_2267 7931562 200 µM -0.575614925403934 0.287812585909033 no 2396 0.28243774519383 3353 934880
SGTC_1335 1486-0900 202 µM -0.576063570376311 0.287654757543792 no 2397 0.282286106919725 3495 X1335
SGTC_1920 st075728 45.7 µM -0.577606044529001 0.287112444403028 no 2398 0.28176506254936 3524 3400306
SGTC_3048 9093155 49.47 µM -0.578042051180251 0.286959238140658 no 2399 0.281617864545602 3487 25236002
SGTC_2133 5320837 200 µM -0.578732171143566 0.286716819427816 no 2400 0.281384952459205 3484 2841355
SGTC_2306 7482397 179.52 µM -0.578757792934877 0.286707821120656 no 2401 0.281376307021039 3506 891448
SGTC_1838 st055369 84.5 µM -0.579380246412864 0.286489258210638 no 2402 0.281166314926978 3473 676036
SGTC_2838 9002687 71.43 µM -0.579505008300591 0.286445459917153 no 2403 0.281124234125716 3420 6457060
SGTC_2502 avocadyne acetate 18.59 µM -0.580564370436184 0.286073693563048 no 2404 0.280767045658292 3456 3952079
SGTC_3078 9116413 49.47 µM -0.581085768811118 0.285890801290533 no 2405 0.280591324754353 3413 17177322
SGTC_3163 9099914 49.47 µM -0.581759395490269 0.285654593836371 no 2406 0.280364378910945 3505 16268368
SGTC_415 dibenzyl ketone 100 µM -0.581881554297184 0.285611768752443 no 2407 0.280323232947519 3453 7593
SGTC_2759 disulfiram 3.38 µM -0.58239233549763 0.285432737830211 no 2408 0.280151221493515 3428 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1842 st055362 61.2 µM -0.584355977177956 0.284744971362304 no 2409 0.279490419204561 3465 676032
SGTC_1179 1021-1431 9.29 µM -0.584751075621549 0.284606683577691 no 2410 0.27935755268552 3450 2840958
SGTC_1747 st037496 66.6 µM -0.586057806977853 0.284149545156121 no 2411 0.278918334458274 3452 723305
SGTC_1255 0566-0045 221 µM -0.586106975610402 0.284132351177609 no 2412 0.278901814470097 3527 2788469
SGTC_3305 9127027 53.8275 µM -0.586878606825458 0.283862581527488 no 2413 0.278642619310831 3408 41905295
SGTC_3065 9113888 49.47 µM -0.587648066871967 0.28359369308668 no 2414 0.27838427031502 3565 16648368
SGTC_3192 9110362 49.47 µM -0.587667905775215 0.283586761979768 no 2415 0.278377610875447 3564 16649480
SGTC_3292 9120825 59.784 µM -0.58833083581786 0.283355201150142 no 2416 0.278155125962343 3547 24824900
SGTC_2070 5230947 200 µM -0.589147538433145 0.283070052412489 no 2417 0.277881152961072 3559 2835538
SGTC_3140 9094243 49.47 µM -0.590433968598657 0.282621179526908 no 2418 0.277449871377441 3552 19291112
SGTC_149 3970-0822 46.1 µM -0.591025657542354 0.282414836982137 no 2419 0.27725161487382 3544 3114250 YBL034C STU1
SGTC_1721 st082152 9.2685 µM -0.591527260361681 0.282239967377869 no 2420 0.277083597709209 3483 5296051
SGTC_744 1594-0068 283 µM -0.592064834511512 0.282052615257212 no 2421 0.276903586903329 3507 668392
SGTC_2006 4011487 200 µM -0.592199569559002 0.28200566759386 no 2422 0.276858478821305 3546 45595294
SGTC_1803 st050068 52.4 µM -0.592899202201349 0.281761945097932 no 2423 0.276624305983256 3583 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_423 5-fluorouracil 457 µM -0.593714675688596 0.281477996739536 no 2424 0.276351482829338 3460 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_432 NS 1619 61.3 µM -0.59382279709152 0.281440359170411 no 2425 0.276315319865118 3519 4552 A K+/calcium channel activator.
SGTC_908 3448-7491 47.7 µM -0.595870774119813 0.280727907738204 no 2426 0.275630779389837 3539 1203031
SGTC_2984 9022109 38.96 µM -0.597975758218348 0.279996534904491 no 2427 0.274928054240555 3579 6459207
SGTC_52 0329-0193 875 nM -0.598253840489658 0.279899984855571 no 2428 0.274835285677892 3584 3739292
SGTC_1297 1068-0111 14.1 µM -0.598542133742792 0.279799906607025 no 2429 0.274739127012543 3458 767057
SGTC_2332 7982454 138.89 µM -0.599045691198191 0.279625143098997 no 2430 0.274571207931506 3508 2981748
SGTC_2893 9048488 25.97 µM -0.599510989870426 0.279463704710818 no 2431 0.274416091857444 3456 6467338
SGTC_245 methotrexate 289.6 µM -0.599691843245908 0.279400968678986 no 2432 0.274355812654005 3492 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2710 st078562 53.7235 µM -0.599841191932272 0.279349166432457 no 2433 0.274306039026413 3480 17250908
SGTC_1892 st058411 7.36 µM -0.602147376108343 0.278549849216142 no 2434 0.273538020522602 3500 3934738
SGTC_1826 st055655 41.6 µM -0.603082981447781 0.278225888884852 no 2435 0.273226743688396 3502 676168
SGTC_1188 1403-0014 4.57 µM -0.605206348778792 0.277491339412153 no 2436 0.272520948968252 3519 9614867
SGTC_904 1141-0088 396 µM -0.607215547771772 0.276797158795198 no 2437 0.27185393771703 3501 1378119
SGTC_927 2425-1185 123 µM -0.607685671803288 0.276634853280742 no 2438 0.271697983903539 3483 730375
SGTC_3258 9138477 49.47 µM -0.608332959679854 0.2764114601088 no 2439 0.271483332587033 3557 4970355
SGTC_3112 9123419 49.47 µM -0.611703161374874 0.27524976158363 no 2440 0.270367084939997 3570 17015854
SGTC_1898 st060199 18.6 µM -0.613644798338268 0.274581578023349 no 2441 0.26972503675351 3541 688866
SGTC_203 k066-0004 30.888 µM -0.614406969648411 0.274319507728578 no 2442 0.269473215655845 3589 6795412
SGTC_140 0062-0056 502.533 µM -0.616003429580118 0.27377097037734 no 2443 0.268946128141446 3512 3758964
SGTC_1602 st001878 87.6 µM -0.61631131601478 0.273665244241733 no 2444 0.268844535865646 3572 595405 YLR310C CDC25
SGTC_1090 efavirenz 20.7 µM -0.61742898366489 0.273281614512955 no 2445 0.268475904778034 3554 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_177 1327-0068 8.361 µM -0.617597051161943 0.27322394985019 no 2446 0.268420494451849 3538 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_539 4859-0462 2.54 µM -0.617692532093556 0.273191192627625 no 2447 0.268389017818225 3559 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2471 5466956 24.79 µM -0.621198361082158 0.271989775760079 no 2448 0.267234558826204 3485 724419
SGTC_1935 st074532 41.6 µM -0.623462082641107 0.271215416817622 no 2449 0.266490455928318 3619 2829742
SGTC_2334 9017922 200 µM -0.626902759970834 0.270040561268898 no 2450 0.265361489005971 3554 3163164
SGTC_1024 4507-0395 26 µM -0.627030356668273 0.269997041048234 no 2451 0.265319668264571 3607 4201836
SGTC_78 0336-0123 156.75 µM -0.627773851976848 0.269743522184996 no 2452 0.265076048855528 3434 6765896
SGTC_1763 st044482 94.5 µM -0.627828893638153 0.269724758684232 no 2453 0.265058017998643 3546 88505
SGTC_2558 carylophyllene oxide 100 µM -0.628165605134521 0.269609989200999 no 2454 0.264947729719062 3637 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1688 st021091 57.6 µM -0.629008899901541 0.269322656165477 no 2455 0.26467161483021 3572 3656366
SGTC_1502 4534-4282 27.7 µM -0.629615458268742 0.269116080529036 no 2456 0.264473103632926 3538 3278949
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.630689970862971 0.268750328958988 no 2457 0.264121628960495 3575 91467 include heat shock
SGTC_1691 st019933 84.6 µM -0.63138491406703 0.268513911434263 no 2458 0.263894438783868 3551 6176082
SGTC_1149 3909-7961 23.3 µM -0.633854649000727 0.267674562156509 no 2459 0.26308784229459 3533 735261
SGTC_619 1652-1634 108 µM -0.634828318043943 0.267344020646826 no 2460 0.262770196045646 3512 5400454
SGTC_2951 9072950 58.06 µM -0.635222556554468 0.267210243012129 no 2461 0.262641636923541 3598 16488155
SGTC_2281 7943571 200 µM -0.635396661110099 0.267151174569372 no 2462 0.262584872582518 3627 1244024
SGTC_226 1,3-diallylurea 8.28947 mM -0.636853343502007 0.266657224435008 no 2463 0.262110187927401 3533 74537 YKL182W FAS1
SGTC_3032 9089427 49.47 µM -0.637259597122479 0.266519549248898 no 2464 0.261977881766848 3554 17173707
SGTC_1342 1486-1464 234 µM -0.638029115796648 0.266258865841291 no 2465 0.261727363582423 3592 3253938
SGTC_914 3820-6779 408 µM -0.640006484453471 0.265589601622149 no 2466 0.261084191846109 3545 2893481
SGTC_506 n9-isopropylolomoucine 153 µM -0.640525733833879 0.26541399697066 no 2467 0.260915432217859 3590 6610355
SGTC_3002 9075603 71.4286 µM -0.641098446396156 0.265220379991512 no 2468 0.26072936177154 3563 20105405
SGTC_1219 1469-0211 33.1 µM -0.641674577786977 0.265025679594239 no 2469 0.26054224948986 3569 6822282
SGTC_969 1313-0238 134 µM -0.64327576860303 0.264484947688682 no 2470 0.260022588258345 3588 5212874
SGTC_640 3381-0960 37.1 µM -0.644334621331378 0.264127675304805 no 2471 0.259679234890389 3621 1745025
SGTC_765 1319-0117 244 µM -0.644792257332143 0.263973338356925 no 2472 0.259530910076409 3583 3487746 YGL099W LSG1
SGTC_2676 harmalol 100 µM -0.645189117901492 0.263839535039667 no 2473 0.259402318670988 3606 5459187 A monoamine oxidase inhibitor
SGTC_695 3505-6186 243 µM -0.645872719122906 0.263609136939078 no 2474 0.259180894295773 3591 1819379
SGTC_279 1273-0055 2.93 µM -0.649580642135432 0.262361225033815 no 2475 0.257981570262067 3622 2847562
SGTC_3077 9117319 49.47 µM -0.65073876403552 0.26197207680459 no 2476 0.257607567742147 3601 17154678
SGTC_2023 5144124 124 µM -0.651732490352738 0.261638404287249 no 2477 0.257286879527882 3574 2830192
SGTC_3266 9136860 49.47 µM -0.653432316035726 0.261068144436917 no 2478 0.256738805433485 3537 4871271 YPR165W RHO1
SGTC_1615 st002656 86.5 µM -0.654349509729711 0.260760708650488 no 2479 0.256443327706673 3612 1584458
SGTC_2512 diallyl trisulfide 49.23 µM -0.655755810720123 0.260289690155121 no 2480 0.255990626395372 3610 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3251 9135047 49.47 µM -0.65803887283934 0.259525948859708 no 2481 0.255256576399809 3595 17682963
SGTC_1913 st060213 96.1 µM -0.658275726399689 0.259446781736012 no 2482 0.255180486311461 3640 688959
SGTC_2775 cyproheptadine 69.59 µM -0.658834999016544 0.259259897160292 no 2483 0.255000864980606 3632 2913 A selective serotonin reuptake inhibitor.
SGTC_1728 st035614 33.7865 µM -0.659254436834042 0.259119784957189 no 2484 0.254866197749938 3578 15945546
SGTC_2150 5556613 200 µM -0.659528713639799 0.259028184618659 no 2485 0.254778156920593 3615 743190
SGTC_2235 salicylic acid 500 µM -0.660472053628757 0.258713264863906 no 2486 0.25447547334646 3616 338 A COX inhibitor and kinase inhibitor.
SGTC_2171 5739187 198.077 µM -0.660671005889783 0.258646872982839 no 2487 0.254411660852932 3552 2262761
SGTC_465 cgp-37157 41 µM -0.661638924079099 0.258323997221811 no 2488 0.25410132780483 3529 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2017 5132927 60.65 µM -0.661782737678114 0.258276042064818 no 2489 0.254055235368563 3591 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2375 9072683 200 µM -0.66216512464388 0.258148556216156 no 2490 0.253932701212533 3663 16798029
SGTC_2148 5546263 113.568 µM -0.664982794811693 0.25721016641232 no 2491 0.253030748834704 3602 792097
SGTC_546 peri-Naphthalide 147 µM -0.66503104855809 0.257194111564768 no 2492 0.253015317227312 3564 223824 A penicillin ester.
SGTC_3005 9076496 71.4286 µM -0.6654299425857 0.257061412651035 no 2493 0.252887769395766 3634 21368410
SGTC_957 1187-1561 14.1 µM -0.667332701021347 0.256428917947897 no 2494 0.252279821445345 3604 1538454
SGTC_2736 butenafine 14.65 µM -0.667605966183638 0.256338148688328 no 2495 0.252192574162044 3609 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_867 0518-0118 155 µM -0.66765006167146 0.256323503257804 no 2496 0.252178496977849 3656 6848158
SGTC_1310 1188-0297 994 nM -0.668556891392097 0.256022414717454 no 2497 0.251889089685068 3583 1588352
SGTC_121 0557-0495 61.343 µM -0.668814422697478 0.255936941989827 no 2498 0.251806932648305 3741 3104427
SGTC_1692 fluoroquinolonic acid 71 µM -0.670424123149466 0.255403031943105 no 2499 0.251293730505605 3634 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1155 4088-0394 48.2 µM -0.6707344804941 0.255300158703359 no 2500 0.251194846498007 3604 2326248
SGTC_2737 bleomycin 30.5 nM -0.671053657568972 0.25519438461058 no 2501 0.25109317387421 3647 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.671632265766026 0.255002694451549 no 2502 0.250908915987871 3676 688751
SGTC_1180 1193-0155 285 µM -0.673169940275043 0.254493636519088 no 2503 0.250419591283522 3623 2921347
SGTC_1298 1079-1278 263 µM -0.673786600323622 0.254289636569231 no 2504 0.250223497532744 3664 2840950
SGTC_553 k007-0256 45.7 µM -0.673917187180927 0.254246447574136 no 2505 0.250181982240066 3667 6287000
SGTC_3254 9136651 49.47 µM -0.675118492106738 0.25384932046248 no 2506 0.249800242923173 3630 16454030
SGTC_2114 5491910 81.25 µM -0.677541194997958 0.253049415454246 no 2507 0.249031321027275 3677 2849228
SGTC_3295 9122362 53.5725 µM -0.678716884104066 0.252661716054239 no 2508 0.248658633005656 3635 4730473
SGTC_1389 3405-0187 19 µM -0.679558997596311 0.252384210145638 no 2509 0.2483918696189 3589 799890
SGTC_1328 1441-0025 69.2 µM -0.679895934590138 0.252273222613872 no 2510 0.248285177989955 3589 4562601
SGTC_2210 7115885 190.385 µM -0.680830535212986 0.251965498563028 no 2511 0.247989363161731 3662 2927039
SGTC_1451 4152-0210 104 µM -0.681197045018893 0.251844876638744 no 2512 0.247873408780426 3638 659563
SGTC_2236 dapsone 200 µM -0.681294491430649 0.251812811212122 no 2513 0.247842584084881 3663 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1348 1493-0373 93.8 µM -0.68138494470692 0.251783048854928 no 2514 0.247813973321358 3639 3010129
SGTC_1565 sinapyl alcohol 95.1 µM -0.682057680438549 0.25156175306925 no 2515 0.24760123942686 3629 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1102 cgs 12066b 26.1 µM -0.682751542346952 0.251333615541854 no 2516 0.247381927203771 3630 6438352 A 5-HT1B full agonist.
SGTC_1066 ketoconazole 628 nM -0.684493983832256 0.250761194058067 no 2517 0.246831643527945 3677 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1197 1601-0112 267 µM -0.684745011740668 0.250678784073846 no 2518 0.246752419973528 3655 7350313
SGTC_2393 9031399 185.94 µM -0.684994199820946 0.250596992275893 no 2519 0.246673790529851 3679 1526623 YDL150W RPC53
SGTC_1716 st033144 30.6155 µM -0.686394320280415 0.250137689277147 no 2520 0.246232242558834 3663 674617
SGTC_850 0388-0143 75.9 µM -0.686694262250134 0.250039352817744 no 2521 0.246137706725197 3626 67273
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.687863609586584 0.249656176345973 no 2522 0.245769337299461 3679 5282362
SGTC_1787 fluconazole 80 µM -0.688133919164415 0.249567644610981 no 2523 0.245684226136464 3581 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_965 1291-5240 308 µM -0.688868956615145 0.249326989669676 no 2524 0.245452868252869 3643 2834598
SGTC_3165 9101544 49.47 µM -0.689106340641851 0.249249295314322 no 2525 0.245378175081702 3647 5002184
SGTC_1396 3511-0007 98.6 µM -0.689254158759777 0.24920092184387 no 2526 0.245331670104517 3619 X1396
SGTC_172 1112-0046 2.638 µM -0.689289210406149 0.249189451927014 no 2527 0.245320643220158 3603 2802135 YIL048W NEO1
SGTC_335 4077-0256 27.6 µM -0.690367384433081 0.248836779250976 no 2528 0.244981591021154 3683 3121989
SGTC_2072 5231554 129 µM -0.690495560018805 0.248794870463835 no 2529 0.244941300560004 3721 789545
SGTC_2340 7987427 183.45 µM -0.691063069157279 0.248609360634816 no 2530 0.244762953704375 3631 2239331
SGTC_703 3875-0075 71.8 µM -0.6923142203737 0.248200639366538 no 2531 0.244370010838548 3697 2850814
SGTC_70 0141-0289 43.283 µM -0.692386138825417 0.248177156219293 no 2532 0.244347434103731 3702 352408
SGTC_3207 9114163 49.47 µM -0.692816795126351 0.248036561117624 no 2533 0.244212265435474 3697 849233
SGTC_3212 9128307 49.47 µM -0.69287724213017 0.248016830562728 no 2534 0.244193296361218 3624 27243542
SGTC_2944 9067346 25.62 µM -0.693109117743526 0.247941151626391 no 2535 0.24412053807711 3609 6473075
SGTC_1519 esterone 74 µM -0.693867752905214 0.247693636474321 no 2536 0.243882574094577 3647 698 A steroid.
SGTC_2924 9010168 62.78 µM -0.694645263731367 0.247440099862183 no 2537 0.243638819253052 3710 2993929
SGTC_1363 1636-0063 10.4 µM -0.695189428673025 0.247262736975375 no 2538 0.243468298193784 3696 6072185
SGTC_2963 9082507 9 µM -0.695593030050401 0.247131232716597 no 2539 0.24334186618502 3676 16459611
SGTC_195 4234-0266 16.654 µM -0.695805195388071 0.247062118507804 no 2540 0.243275417585882 3668 2303354
SGTC_2300 7976697 71.57 µM -0.696880926207841 0.246711851530673 no 2541 0.242938657705683 3597 2236109
SGTC_1323 1348-1351 11.2 µM -0.697135726814157 0.246628925284882 no 2542 0.242858928778957 3631 6989654
SGTC_2450 5739737 12.93 µM -0.697223807975563 0.246600262263743 no 2543 0.24283137084906 3675 2262825
SGTC_2280 7785178 200 µM -0.698299854350727 0.246250243628293 no 2544 0.242494845157708 3678 2954328
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.699056149128886 0.246004393958248 no 2545 0.242258470708239 3698 5379071
SGTC_1410 3909-8106 77.9 µM -0.701889543600715 0.245084510975444 no 2546 0.241374025182525 3685 1039210
SGTC_919 tnp00227 403.569 nM -0.702521509271871 0.244879591169697 no 2547 0.241176996319158 3688 1269246 A methoxyflavone. YNL221C POP1
SGTC_3124 9127567 49.47 µM -0.702560374043528 0.244866991974269 no 2548 0.241164882246495 3639 17592030
SGTC_2409 alverine citrate 63.97 µM -0.703034404101325 0.244713348823704 no 2549 0.241017154635796 3796 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_931 2812-0076 566 µM -0.703293515607995 0.2446293872589 no 2550 0.240936425448623 3705 3450959
SGTC_3164 9100705 49.47 µM -0.703523806433867 0.244554777667623 no 2551 0.240864688024627 3666 17174235
SGTC_532 1548-0774 215 µM -0.70368384288056 0.244502936300195 no 2552 0.240814842242758 3777 5932993
SGTC_1444 4112-3581 28 µM -0.704656408518659 0.244188015837651 no 2553 0.24051204263343 3713 2877249
SGTC_2266 7929956 200 µM -0.705436161012227 0.243935687054919 no 2554 0.240269423496605 3673 2967153
SGTC_392 N-ethylmaleimide 8.33 µM -0.705875679177031 0.243793520504641 no 2555 0.240132726691639 3662 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1558 st069300 45.6 µM -0.705970905298772 0.243762724557702 no 2556 0.240103115514043 3633 24208000
SGTC_2185 6113692 200 µM -0.707334384074464 0.24332200848799 no 2557 0.239679351349829 3669 874150
SGTC_1231 0242-0792 125 µM -0.708814128133542 0.242844199784509 no 2558 0.239219914608434 3684 3707635
SGTC_1064 honokiol 6.76 µM -0.709105188451333 0.242750276329275 no 2559 0.239129601728081 3701 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_3006 9075424 71.4286 µM -0.709772052260032 0.242535157448188 no 2560 0.238922751350194 3694 7465181
SGTC_2297 7971671 152.32 µM -0.710024274322259 0.242453821834039 no 2561 0.238844541651572 3684 909016
SGTC_355 1311-2252 105 µM -0.711497990950955 0.241978878812214 no 2562 0.238387847672763 3696 5338538
SGTC_543 3844-1095 191 µM -0.713498595067361 0.241334941113739 no 2563 0.237768641093247 3708 4230703
SGTC_2467 5474540 200 µM -0.715004221323819 0.240850937442502 no 2564 0.237303217431485 3682 5413519
SGTC_1366 1683-0113 21.9 µM -0.717207515753545 0.240143611899241 no 2565 0.236623031256059 3718 708623
SGTC_1350 1495-0454 146 µM -0.71801988276576 0.239883102985131 no 2566 0.236372513708975 3711 1069057
SGTC_233 rapamycin 362 pM -0.719020766568162 0.239562352789741 no 2567 0.236064062273591 3708 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_628 1636-0253 16 µM -0.719961773470377 0.23926100482904 no 2568 0.235774266026525 3706 4456143
SGTC_260 nsc-65238 3.989 µM -0.721189361506586 0.238868193670673 no 2569 0.235396508154795 3643 3246252
SGTC_2751 anetholtrithion 17.25 µM -0.7248974425312 0.237683803797939 no 2570 0.234257474978552 3705 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1003 4049-0218 100 µM -0.726705646975173 0.237107419985081 no 2571 0.233703146699275 3723 295161
SGTC_3036 9090181 49.47 µM -0.727312728484665 0.236914078841158 no 2572 0.233517201250488 3735 25236586
SGTC_3239 9133757 49.47 µM -0.72886559322146 0.236419922655109 no 2573 0.233041941628248 3717 17036923
SGTC_1367 1812-0510 76.9 µM -0.730086238872637 0.236031884605598 no 2574 0.232668736167268 3740 1142582 YDR527W RBA50
SGTC_2448 5185112 27.17 µM -0.730450833672362 0.235916049574284 no 2575 0.232557327848901 3711 5718189
SGTC_3166 9102297 49.47 µM -0.731049308668527 0.235725976658604 no 2576 0.232374517664064 3699 25237072
SGTC_2995 9067767 71.4286 µM -0.731205992528685 0.235676228535021 no 2577 0.232326670215675 3728 11673567
SGTC_2253 7938677 135.83 µM -0.731896375449422 0.235457096541991 no 2578 0.23211590932077 3751 2301972
SGTC_200 k038-0079 37.545 µM -0.731993220872598 0.235426366174847 no 2579 0.232086352752231 3679 3436683
SGTC_349 k015-0014 24 µM -0.732560557879303 0.235246386914437 no 2580 0.231913247425467 3724 2196908
SGTC_344 k064-0035 6.43 µM -0.733690474097471 0.234888164159145 no 2581 0.231568702773174 3718 5088750
SGTC_470 aa-861 153 µM -0.734056700748497 0.234772122291469 no 2582 0.231457090764374 3743 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2569 tetrandrine 100 µM -0.734709017039687 0.234565509135265 no 2583 0.231258363784877 3750 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_404 fumagillin 50 µM -0.734878052192466 0.234511985743558 no 2584 0.231206883063526 3723 12015870 A methionine aminopeptidase binder.
SGTC_2627 acetyl isogambogic acid 100 µM -0.735100493310859 0.234441562151477 no 2585 0.231139146962997 3716 6857789 A caspase activator and apoptosis inducer.
SGTC_2416 tofa 880 nM -0.736407307960275 0.234028068460546 no 2586 0.230741429276645 3756 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1391 3442-0225 151 µM -0.736508085354872 0.233996197926046 no 2587 0.230710774436466 3694 5227075
SGTC_1450 4112-4260 37.6 µM -0.73682579845788 0.23389573789434 no 2588 0.230614146184973 3715 1633175
SGTC_1486 3970-0793 4.53 µM -0.737857850998072 0.233569570600967 no 2589 0.230300417102417 3790 2844330
SGTC_2001 4023502 57.655 µM -0.739253664047857 0.233128842881819 no 2590 0.229876490012681 3758 108941 YCR052W RSC6
SGTC_777 1315-0167 517 µM -0.739457701216529 0.23306445688258 no 2591 0.229814557813201 3768 4221767
SGTC_1070 indatraline 8.81 µM -0.739899501040316 0.232925076307497 no 2592 0.229680488605934 3741 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_673 1082-0474 110 µM -0.740378663790737 0.232773960698096 no 2593 0.229535130725463 3756 3098046
SGTC_897 1000-0139 31.4 µM -0.740403776179659 0.232766042399121 no 2594 0.229527514101711 3698 6151020
SGTC_294 k038-0071 157 µM -0.740498166323164 0.232736281162093 no 2595 0.229498886701689 3746 24152826
SGTC_1729 st035615 45.989 µM -0.740810774624369 0.232637730783788 no 2596 0.229404090635204 3808 17385451
SGTC_2649 anisomycin 9.56 µM -0.74126398238755 0.232494897352322 no 2597 0.229266697842512 3730 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_966 1300-0360 30.2 µM -0.742107936587763 0.232229045872579 no 2598 0.229010970796238 3741 70588
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.743502619810552 0.231790081890298 no 2599 0.228588718000026 3789 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2702 st077768 96.8 µM -0.74356019563628 0.231771970358266 no 2600 0.228571295808356 3693 6484119
SGTC_46 0329-0187a 2.197 µM -0.744344899573586 0.231525205955519 no 2601 0.228333922212098 3799 46494817
SGTC_160 3453-0671 289.699 µM -0.745983922546644 0.231010258174893 no 2602 0.227838563578569 3763 5322268
SGTC_1792 st045773 43.6 µM -0.746440798226446 0.230866831128003 no 2603 0.227700590809792 3672 2919270
SGTC_1508 1080-0625 72.9 µM -0.747731999473682 0.230461753110383 no 2604 0.227310912849218 3672 767111
SGTC_2423 st077119 87.2 µM -0.748260829135498 0.23029596245318 no 2605 0.227151423279987 3697 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2925 9010536 32.5 µM -0.749249275752484 0.229986258570278 no 2606 0.22685348718364 3738 2994177
SGTC_2256 7954252 200 µM -0.750036503053119 0.22973976833467 no 2607 0.226616360091659 3731 2972920
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.751185794549931 0.229380177291419 no 2608 0.226270424074593 3743 16623 A steroid.
SGTC_379 3970-0972 5.9 µM -0.751466247126638 0.229292477023359 no 2609 0.226186053329934 3765 2898042 YBL034C STU1
SGTC_760 0568-0725 82.9 µM -0.753854800225061 0.228546315390858 no 2610 0.225468207018475 3805 3916171
SGTC_1564 D-Arginine 115 µM -0.754196166759226 0.228439787185823 no 2611 0.225365719498986 3753 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1672 st016598 6.51 µM -0.754931711968171 0.228210344855461 no 2612 0.225144978493611 3795 4665860 YNL267W PIK1
SGTC_597 k018-0003 82.8 µM -0.756188565734145 0.227818588104242 no 2613 0.224768073653186 3853 6786234
SGTC_2272 7805186 180 µM -0.757352830707097 0.227456028847244 no 2614 0.224419253754219 3731 2956062 YPR165W RHO1
SGTC_1600 coumarin 106 71.1 µM -0.757691379006393 0.227350663852637 no 2615 0.224317880594049 3864 100336 A hepatotoxic, DNA x-linker.
SGTC_405 ebelactone b 50 µM -0.757715809479535 0.227343061520914 no 2616 0.224310566264685 3745 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2009 4012297 12.05 µM -0.758816075792164 0.227000826592378 no 2617 0.223981293869416 3776 45595307
SGTC_2553 4-methylesculetin 85.09 µM -0.759366571197277 0.226829705550039 no 2618 0.223816652390937 3824 5319502
SGTC_1587 estradiol valerate 56.1 µM -0.760779237325966 0.226390912603114 no 2619 0.223394468875116 3764 13791 A steroid.
SGTC_170 4197-0004 226 µM -0.761434152245138 0.226187650042631 no 2620 0.223198897560871 3798 218692
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.762562492598681 0.225837694870965 no 2621 0.222862180215288 3723 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_998 3996-0085 177 µM -0.764472002718416 0.225246157779672 no 2622 0.222293007394045 3809 715391
SGTC_1325 1431-0015 227 µM -0.765292393635736 0.224992282949794 no 2623 0.222048726193807 3735 1103340
SGTC_2135 5326629 150.42 µM -0.765344974216849 0.224976017109223 no 2624 0.222033074924901 3760 5020077
SGTC_1628 st004252 77.7 µM -0.767928518705559 0.224177617086689 no 2625 0.221264826639234 3791 692968
SGTC_36 0335-0881 14.2 µM -0.768881165026522 0.223883624651879 no 2626 0.220981929840084 3723 23828853
SGTC_1949 st076024 69.1 µM -0.768971855578738 0.223855648423998 no 2627 0.220955009270471 3747 2921930
SGTC_2226 7298446 200 µM -0.770335347665115 0.223435277847539 no 2628 0.220550496826307 3761 3283010
SGTC_3115 9123671 49.47 µM -0.771522963779744 0.22306949683982 no 2629 0.220198508196549 3873 3286988
SGTC_2381 9035592 200 µM -0.772354700370132 0.222813528458799 no 2630 0.21995218795912 3815 4749657
SGTC_888 0916-0002 6.97 µM -0.772404254832578 0.222798283271428 no 2631 0.219937517311249 3882 2802138 YIL048W NEO1
SGTC_1265 0819-1001 68.8 µM -0.77259582440023 0.222739353423978 no 2632 0.219880808231715 3769 3106768
SGTC_993 3909-8757 62.7 µM -0.772758451940026 0.222689333576998 no 2633 0.21983267325687 3771 4288324 YLR208W SEC13
SGTC_1862 st057513 3.81 µM -0.773123044605343 0.222577217971624 no 2634 0.219724782035569 3775 5393163
SGTC_2999 9069765 71.4286 µM -0.774229616840809 0.22223713394249 no 2635 0.219397508489292 3817 2097066
SGTC_1883 5-benzylidenerhodanine 20 µM -0.777898000379233 0.221111848850578 no 2636 0.218314573607535 3803 1273210
SGTC_1394 3474-0001 65.7 µM -0.778348893032098 0.220973761837827 no 2637 0.218181679489626 3799 5017666 YIL048W NEO1
SGTC_3037 9091026 49.47 µM -0.778788428356853 0.220839200559398 no 2638 0.218052177664758 3804 25236398 YIL048W NEO1
SGTC_3000 9075062 71.4286 µM -0.780592572545601 0.220287363692107 no 2639 0.217521080812782 3785 17057871
SGTC_2842 9000675 19.48 µM -0.784453831788391 0.219108973852272 no 2640 0.216386931002983 3826 2989072
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.784750376424855 0.219018623652092 no 2641 0.216299970068735 3786 6708514
SGTC_1887 st057648 70.8 µM -0.786375092623405 0.218523991146602 no 2642 0.215823885524589 3845 688672
SGTC_125 0133-0007 11.75 µM -0.786812379588963 0.218390972392005 no 2643 0.215695852752608 3888 26541
SGTC_1449 4112-4002 201 µM -0.786863005048126 0.218375575596329 no 2644 0.215681033024328 3832 2059539
SGTC_1245 0418-0076 17.2 µM -0.787687288163346 0.218124973138412 no 2645 0.21543982145362 3862 6790114
SGTC_3070 9117005 49.47 µM -0.789464474939967 0.217585228700448 no 2646 0.214920292580839 3844 8779016
SGTC_2514 salinomycin 42.74 µM -0.789480247531638 0.217580441903924 no 2647 0.214915685004902 3906 23682228 A polyether potassium ionophore.
SGTC_2078 5212016 200 µM -0.789720426074705 0.217507558043299 no 2648 0.214845529821354 3717 1899708
SGTC_129 0088-0017 176.636 µM -0.789773918625701 0.217491327273209 no 2649 0.214829906674627 3690 182446
SGTC_280 3448-3607 3.04 µM -0.791235612576655 0.217048089085672 no 2650 0.214403256751969 3804 626179
SGTC_679 0422-0091 41.4 µM -0.792632012443013 0.216625138355783 no 2651 0.213996125941954 3815 627384 YHR062C RPP1
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.796883474321097 0.215340366948315 no 2652 0.212759354696853 3891 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2090 5301565 104.445 µM -0.79840065138982 0.214882955902236 no 2653 0.21231901269709 3831 2056344
SGTC_2789 5281112 71.43 µM -0.798577127942983 0.214829786962722 no 2654 0.212267827148549 3852 765948
SGTC_2990 9074105 71.4286 µM -0.799530507372155 0.214542684556571 no 2655 0.211991432171878 3774 6502001
SGTC_541 4513-1321 94 µM -0.801592588625946 0.213922469208997 no 2656 0.211394333083838 3832 747515
SGTC_725 1497-0963 19 µM -0.802286719773156 0.21371392937947 no 2657 0.211193561317766 3865 3549977
SGTC_3079 9117512 49.47 µM -0.803260387533665 0.213421607194527 no 2658 0.210912124239187 3845 7185044
SGTC_309 k408-0051 1.48 µM -0.804347645634936 0.213095457622867 no 2659 0.210598114091321 3794 3640463
SGTC_1906 st060206 94.7 µM -0.804799455224728 0.212960011881982 no 2660 0.210467708047815 3836 5133468
SGTC_1194 1488-0194 225 µM -0.806631395626591 0.212411338662188 no 2661 0.209939440033745 3799 1391452
SGTC_1785 bathophenanthroline 24 µM -0.806938206616758 0.21231952840205 no 2662 0.209851042638952 3781 72812 An iron chelator.
SGTC_996 3970-0799 1.8 µM -0.812313270573399 0.21071485751986 no 2663 0.20830594886035 3891 6615648 YGL040C HEM2
SGTC_1125 tnp00248 1.32998 µM -0.812374662503726 0.210696570770078 no 2664 0.208288340241221 3948 24207736
SGTC_2119 5528445 120.635 µM -0.812489555480144 0.21066235022158 no 2665 0.208255388649862 3863 791935
SGTC_2549 cedrol 20.94 µM -0.812817566311785 0.210564671067227 no 2666 0.208161331253889 3773 6708665 A sedative which affects the nervous system.
SGTC_276 colchicine 750 µM -0.813462454011068 0.210372705882587 no 2667 0.207976482246628 3933 2833 A microtubule depolymerizer.
SGTC_467 ro 31-8220 72.8 µM -0.814502602991564 0.210063298977284 no 2668 0.207678540821985 3786 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2468 5987765 72.9 µM -0.814855544472291 0.209958372364364 no 2669 0.207577501200214 3894 26772094
SGTC_2719 novobiocin 32.65 µM -0.815537439016868 0.209755737958005 no 2670 0.207382371626322 3830 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2368 9071271 200 µM -0.816510170115235 0.209466876530847 no 2671 0.207104204610577 3863 27209959
SGTC_347 4534-1311 26.2 µM -0.816822533020542 0.209374167167058 no 2672 0.207014926604015 3855 2862016
SGTC_3045 9092950 49.47 µM -0.818661048726406 0.208828984902171 no 2673 0.206489912857898 3819 44120432
SGTC_2726 cimetidine 79.27 µM -0.818823406887348 0.208780880427917 no 2674 0.206443587161103 3847 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1662 st014054 52 µM -0.818946063223949 0.208744543384604 no 2675 0.206408593679809 3870 2838777
SGTC_1034 k072-0165 12.7 µM -0.819276123061364 0.20864678138953 no 2676 0.206314446063443 3876 5835461
SGTC_1487 3970-0795 2.82 µM -0.819636787697712 0.208539985277845 no 2677 0.206211597714259 3913 3765103
SGTC_639 0833-0042 114 µM -0.822001348308221 0.207840615883773 no 2678 0.205538064766482 3843 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1038 k292-0204 154 µM -0.822262784366984 0.207763375706785 no 2679 0.205463676320408 3815 4454212
SGTC_3049 9092223 49.47 µM -0.822808914456519 0.207602078597646 no 2680 0.205308333245487 3848 8623917
SGTC_3234 9132280 49.47 µM -0.823306471669215 0.207455191707813 no 2681 0.205166867157032 3906 17612295
SGTC_864 0469-0573 172 µM -0.823921053603471 0.207273842068044 no 2682 0.204992208436465 3855 689425
SGTC_1539 benzyladenosine 56 µM -0.824190800393435 0.207194275322507 no 2683 0.20491557671691 3844 92208 A nucleotide analog.
SGTC_764 1951-2361 146 µM -0.825934026147719 0.206680514785182 no 2684 0.204420758730297 3845 5438930
SGTC_1384 3089-0840 101 µM -0.827577316170073 0.206196898558227 no 2685 0.203954959556488 3828 1069836
SGTC_3132 9126706 49.47 µM -0.82806318031323 0.206054038528279 no 2686 0.203817360051779 3931 850858
SGTC_2049 5262831 67.185 µM -0.830277976158341 0.205403559739295 no 2687 0.203190818567543 3920 763417
SGTC_2949 9072542 2.23 µM -0.831153158612274 0.205146857857165 no 2688 0.202943556280679 3955 16457352
SGTC_1331 1472-0049 76.2 µM -0.832813830346309 0.204660286617917 no 2689 0.202474866724366 3823 24051409
SGTC_2136 5328288 199.296 µM -0.833046630818991 0.204592131772709 no 2690 0.202409215462093 3901 262395
SGTC_428 3448-4153 16.5 µM -0.835799457117845 0.203787236703616 no 2691 0.201633865981301 3853 3834874
SGTC_2323 6148992 148.28 µM -0.83632409947539 0.203634051682759 no 2692 0.20148629952559 3866 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_468 gf-109203x 121 µM -0.838593727101434 0.202972157495194 no 2693 0.200848665977306 3843 2396 A protein kinase C inhibitor.
SGTC_3172 9105863 49.47 µM -0.838642715934107 0.202957885004327 no 2694 0.200834916324497 3885 2348785
SGTC_796 1234-0020 70.7 µM -0.839644007703561 0.20266629828023 no 2695 0.20055400841865 3813 46495034
SGTC_1741 st038134 10.228 µM -0.839915463080978 0.202587290768959 no 2696 0.200477893503936 3949 1272587
SGTC_823 0417-1665 178 µM -0.841342028193003 0.202172389458804 no 2697 0.20007817605808 3910 3429856
SGTC_2371 9071574 200 µM -0.84362231699051 0.20151024845019 no 2698 0.199440244706692 3886 45596039
SGTC_3027 9089541 49.47 µM -0.844552597012257 0.201240491132855 no 2699 0.199180342539968 3902 9943819
SGTC_2383 9036125 200 µM -0.845497217444168 0.20096679712809 no 2700 0.198916642802787 3806 79580
SGTC_148 3253-0744 288.01 µM -0.845764681873702 0.200889342660185 no 2701 0.198842015815757 3827 6893655
SGTC_715 0868-0130 184 µM -0.847632981685646 0.200348805332574 no 2702 0.198321200200029 3922 2876258
SGTC_847 0342-0274 5.54 µM -0.848095451568492 0.200215138379089 no 2703 0.198192407255195 3899 18097
SGTC_647 0140-0236 81 µM -0.848377928911224 0.200133520760945 no 2704 0.198113765163867 3905 990837
SGTC_856 0433-0016 11.3 µM -0.848602794269388 0.200068563565331 no 2705 0.198051175801447 3950 3911780
SGTC_3311 9131146 2.8755 µM -0.849145952439153 0.199911712933954 no 2706 0.197900041602222 3887 4900406 YPR165W RHO1
SGTC_1032 k061-1018 98.7 µM -0.849739215043061 0.199740477904485 no 2707 0.197735045433826 4028 4005393
SGTC_2956 9076196 2.52 µM -0.8514615977899 0.199243841985697 no 2708 0.197256493453893 3923 16423868
SGTC_2208 7283366 200 µM -0.854723071062028 0.19830546088815 no 2709 0.196352237570809 3872 898663
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.854815384896127 0.198278939509748 no 2710 0.196326679829374 3885 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1735 st034310 56.75 µM -0.855424165093285 0.198104093122679 no 2711 0.196158185208413 4010 871153
SGTC_1605 st000082 49.1 µM -0.8584367244981 0.197240233785109 no 2712 0.195325678092243 3911 1114022
SGTC_924 2046-0044 21.3 µM -0.859036964840506 0.197068385949059 no 2713 0.19516006121966 3916 3623589
SGTC_3147 9097027 49.47 µM -0.861397234560105 0.196393523724601 no 2714 0.194509649318303 3941 25236841
SGTC_2791 5663188 71.43 µM -0.862159616778831 0.196175838560166 no 2715 0.194299844332047 3948 54690634
SGTC_749 1000-0129 128 µM -0.862688387084553 0.196024943238014 no 2716 0.194154409511552 3977 708470
SGTC_3130 9127414 49.47 µM -0.862811372250376 0.195989857023431 no 2717 0.194120592751665 3916 1494646
SGTC_2154 5570129 200 µM -0.866384762928508 0.194972075107265 no 2718 0.193139598483163 3947 673366
SGTC_535 2293-4129 48.2 µM -0.866407643454001 0.194965568591302 no 2719 0.193133326915121 3955 396118 YIL048W NEO1
SGTC_3277 9138724 49.47 µM -0.867213609338109 0.194736460984256 no 2720 0.192912490429577 3867 15943418
SGTC_685 1278-0033 54.9 µM -0.868427279700321 0.194391766573822 no 2721 0.192580233121149 3943 3590572
SGTC_1016 4226-1401 38 µM -0.868750660113055 0.19429998604013 no 2722 0.192491762773149 3895 2901613
SGTC_2899 9053889 58.44 µM -0.868857127406411 0.194269774693969 no 2723 0.192462640910172 3874 6470052
SGTC_1145 3546-0597 10.2 µM -0.869469073631541 0.194096183237495 no 2724 0.192295308280387 3904 875334
SGTC_1663 st014140 55.4 µM -0.870132026681356 0.193908229294023 no 2725 0.192114128620192 3998 4207120
SGTC_190 3970-0790 3.722 µM -0.870279303960326 0.19386648974801 no 2726 0.192073893124713 3843 2832352
SGTC_2163 5671233 125 µM -0.87031721144162 0.193855747354118 no 2727 0.192063537804413 3920 701023
SGTC_422 cantharidin 155 µM -0.871490926929887 0.193523314091654 no 2728 0.191743078872308 3877 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_126 0417-1624 672.48 µM -0.871785770820647 0.193439859676076 no 2729 0.191662629281051 3988 41912 YDL195W SEC31
SGTC_204 PMA1.184 62.41 µM -0.871812381633981 0.193432328669315 no 2730 0.191655369408297 3962 2252213 YGL008C PMA1
SGTC_2734 clemastine 41.6 µM -0.872091058716932 0.193353472265327 no 2731 0.191579351779778 3945 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1 0258-0098 57.368 µM -0.873825087995196 0.192863240195295 no 2732 0.191106757821778 3875 6790032 YDR047W HEM12
SGTC_642 0335-0876 158 µM -0.873858404936438 0.192853828513605 no 2733 0.191097684596662 3962 6812350
SGTC_287 k060-0039 29.6 µM -0.874324891337698 0.192722080531289 no 2734 0.190970673783064 3975 5861974
SGTC_106 0092-0003 11.579 µM -0.875361015401822 0.192429648742944 no 2735 0.190688752321111 3850 1072148
SGTC_579 4491-1009 110 µM -0.876156645152868 0.192205277432096 no 2736 0.190472441007451 4067 1271041
SGTC_1104 tacrolimus 29.8 µM -0.87671276877589 0.192048543034917 no 2737 0.190321334765405 3955 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_701 4424-0219 185 µM -0.876852190132067 0.192009261658608 no 2738 0.190283463661333 3995 2911779
SGTC_15 0266-0086 27.098 µM -0.878650014535084 0.191503172858331 no 2739 0.189795534377621 4013 1712902 YIL048W NEO1
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.879030840254028 0.191396075143083 no 2740 0.189692277167933 3907 688803
SGTC_2881 9058953 51.95 µM -0.880021214679728 0.191117728976603 no 2741 0.189423908537939 3906 17122249
SGTC_1658 st012944 20 µM -0.881665890675567 0.190656039107642 no 2742 0.188978755806422 3841 24207260
SGTC_1650 st011916 45.8 µM -0.882430486349104 0.190441636776137 no 2743 0.188772027764828 3867 242528
SGTC_2254 7938975 95.19 µM -0.882494518142166 0.190423688169991 no 2744 0.188754721455095 4007 2969277
SGTC_1797 st048695 56.8 µM -0.88261620152873 0.19038958223989 no 2745 0.188721835950714 3925 592262 YIL048W NEO1
SGTC_2043 5101342 149 µM -0.883624474037712 0.190107123743939 no 2746 0.188449481471488 3952 678451
SGTC_868 0527-0199 213 µM -0.884358948922406 0.189901529403118 no 2747 0.188251237868978 3901 2849450
SGTC_2284 7945075 39.21 µM -0.88465821448729 0.189817798143757 no 2748 0.188170499403744 3979 1245402
SGTC_2593 nobiletin 86.24 µM -0.886958847792547 0.189174864251015 no 2749 0.187550528370415 3975 72344 An anti-infammatory.
SGTC_980 1473-0395 201 µM -0.887931236301149 0.1889035246592 no 2750 0.187288870573367 3844 768876
SGTC_984 1492-0255 2.91 µM -0.890558040081939 0.188171729376797 no 2751 0.186583159092252 3928 1585198
SGTC_3013 9080133 71.4286 µM -0.89106349832757 0.188031115882082 no 2752 0.186447552907295 4051 17050193
SGTC_1951 sophoraflavanone G 9.2 µM -0.894257205884951 0.187144158377 no 2753 0.185592145467728 3931 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_601 0986-0029 62.9 µM -0.894852178132977 0.186979208875562 no 2754 0.185433056724849 3916 24747981
SGTC_3203 9113543 49.47 µM -0.895413333741052 0.186823717118697 no 2755 0.185283087758435 4062 17018012
SGTC_1427 4048-4900 550 nM -0.895510475315426 0.186796808089034 no 2756 0.185257134299331 3961 24132586
SGTC_1386 3228-0095 33.8 µM -0.895962845432005 0.186671529377226 no 2757 0.185136303638334 3996 870181
SGTC_1146 3579-1023 7 µM -0.897830635180616 0.18615481742067 no 2758 0.184637924746281 4013 X1146
SGTC_3289 9119912 71.43 µM -0.898556878294061 0.185954146539117 no 2759 0.184444368088245 4003 17014829
SGTC_429 1112-0049 25.5 µM -0.899493190755759 0.185695628650787 no 2760 0.184195010565536 3936 2836170
SGTC_1789 tunicamycin 25 nM -0.89990141347113 0.185582987311053 no 2761 0.184086358931696 3898 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3169 9102970 49.47 µM -0.900437917799529 0.185435013580669 no 2762 0.183943624842809 4024 17027839
SGTC_1320 1313-0481 95.3 µM -0.900540830537364 0.185406637502018 no 2763 0.183916253342595 3966 6813365 YLR208W SEC13
SGTC_1613 st002381 52.1 µM -0.900792562742065 0.185337238866569 no 2764 0.183849311309998 3961 551167
SGTC_466 geldanamycin 89.2 µM -0.900866939967754 0.185316737314553 no 2765 0.183829535407817 3881 5288382 HSP90 inhibitor.
SGTC_215 1287-0124 461.5 µM -0.902601804078002 0.184838933925681 no 2766 0.18336863436089 3981 5560863
SGTC_3257 9139206 32.98 µM -0.902640770651911 0.184828210840789 no 2767 0.183358290397813 3979 4910041
SGTC_989 1501-0895 10.3 µM -0.905027586173597 0.184172128156181 no 2768 0.182725386461615 3916 2830112
SGTC_353 1988-1175 58.3 µM -0.909148921348473 0.183042681831705 no 2769 0.181635761054727 3822 2788357
SGTC_2648 atorvastatin 78.68 µM -0.910328447843425 0.182720231249466 no 2770 0.181324660066287 3994 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_851 0394-0702 453 µM -0.912142413672822 0.182225034704582 no 2771 0.180846876790499 3979 762646
SGTC_907 3448-6986 75.5 µM -0.91268784515368 0.182076300930215 no 2772 0.180703369194161 4019 590582
SGTC_2403 6032726 181.2 µM -0.913018544921732 0.181986159340664 no 2773 0.18061639409103 4038 2881040
SGTC_2732 terfenadine 20 µM -0.914303971161797 0.181636045111887 no 2774 0.180278572251391 3991 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_3248 9135562 49.47 µM -0.914545541360139 0.181570295211998 no 2775 0.180215129670672 3984 17650701
SGTC_832 4083-0019 164 µM -0.915019436556004 0.181441355024104 no 2776 0.18009071325185 4048 1990758
SGTC_2865 9030313 51.95 µM -0.916576368644162 0.181018139456068 no 2777 0.17968233611394 3936 42562754
SGTC_696 1560-0013 611 µM -0.917021445079242 0.180897269611853 no 2778 0.17956570134967 4045 1650269
SGTC_978 1416-0512 87.4 µM -0.917143679172605 0.180864083234655 no 2779 0.179533677553458 4062 6814003
SGTC_1678 st019265 80.2 µM -0.917168921529084 0.180857230447276 no 2780 0.179527064820521 4015 5367020
SGTC_3031 9088762 49.47 µM -0.919345256374926 0.18026701169667 no 2781 0.178957506677438 3973 205253
SGTC_1857 st056007 79.3 µM -0.920095126430082 0.180063928377856 no 2782 0.17876152546893 3989 619834
SGTC_2597 laccaic acid a 100 µM -0.92011184753035 0.180059401529023 no 2783 0.178757156890455 4021 5491415 A textile dye.
SGTC_3188 9110789 49.47 µM -0.92259565523069 0.17938776211801 no 2784 0.178108980358507 3976 849217
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.922690599956901 0.179362119678055 no 2785 0.178084232939793 3998 4620898
SGTC_1515 3460-0031 42.1 µM -0.923932019424281 0.179027052234066 no 2786 0.17776085546106 3920 2876596
SGTC_661 1304-0007 33.6 µM -0.924384822250266 0.178904935800802 no 2787 0.177642997068572 4004 3117130
SGTC_2594 a-mangostin 100 µM -0.925623648290475 0.178571104692485 no 2788 0.177320799634055 4047 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_815 1582-0027 36.9 µM -0.926326458234925 0.178381890387334 no 2789 0.177138174962756 4069 3128206
SGTC_1980 st071811 45.7 µM -0.928048910359478 0.177918696881072 no 2790 0.176691099609094 4096 4974850
SGTC_755 1995-0008 37.3 µM -0.928494729423321 0.17779893305171 no 2791 0.176575500255659 3965 689533
SGTC_2147 5545932 89.7195 µM -0.92937402379446 0.177562870495341 no 2792 0.176347642476388 4035 797404
SGTC_1087 pterostilbene 9.05 µM -0.931150233293661 0.177086618460165 no 2793 0.175887928496587 4072 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2074 5212007 75.395 µM -0.932567698791015 0.176707135366838 no 2794 0.175521608747171 3858 758611
SGTC_1241 0364-0022 50.8 µM -0.932944289728055 0.176606401153158 no 2795 0.175424366608365 4030 4563895
SGTC_1481 3346-2004 36 µM -0.933710732898907 0.176401497652331 no 2796 0.175226563546944 4036 2770522
SGTC_848 0368-0089 85.6 µM -0.93468870276734 0.176140262378649 no 2797 0.174974375313822 4027 762535
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.935348610217982 0.175964126368025 no 2798 0.174804335753219 4047 551469
SGTC_2453 5731132 22.18 µM -0.936703920356706 0.175602730194982 no 2799 0.174455439550535 4059 1362040
SGTC_1984 st072354 53.1 µM -0.93914066434504 0.174954151498249 no 2800 0.173829264278042 3900 5762938
SGTC_1596 piperlongumine 63 µM -0.942560754997848 0.174046406730444 no 2801 0.172952810719117 4066 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1931 st074438 57.1 µM -0.943310284753307 0.173847870687333 no 2802 0.172761108393017 3990 2787313
SGTC_1452 4194-0072 190 µM -0.943418140324539 0.173819313675864 no 2803 0.172733534029672 4088 1343545
SGTC_1281 0884-0031 11.8 µM -0.943523434277785 0.173791437784415 no 2804 0.17270661727624 4039 1548255
SGTC_2872 9044037 25.97 µM -0.94361683667105 0.173766712486463 no 2805 0.172682742652296 4018 6465195
SGTC_926 2268-1401 59.4 µM -0.943655483298083 0.1737564826818 no 2806 0.172672864787573 3985 2931578
SGTC_352 k048-0007 5.11 µM -0.943943943265339 0.173680139112661 no 2807 0.172599147389927 4015 6811911
SGTC_1395 3486-0190 4.35 µM -0.94455179137552 0.173519336425705 no 2808 0.172443874448675 3994 6748079
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.946483424268203 0.173008963375165 no 2809 0.171951036379723 4018 2724 A muscle relaxant with antifungal properties.
SGTC_2563 tomatine 8.54 µM -0.947186675923985 0.172823389027925 no 2810 0.171771831817249 3907 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1312 1218-2183 165 µM -0.947473216347451 0.172747813007399 no 2811 0.171698848997076 4043 6744073
SGTC_1372 2752-0194 270 µM -0.947888148455583 0.172638410585709 no 2812 0.171593199494043 3974 823334
SGTC_698 k064-0052 127 µM -0.949114432983727 0.172315342461622 no 2813 0.171281207265417 4099 5088751
SGTC_706 4262-0057 46.9 µM -0.949631082238074 0.172179345316058 no 2814 0.171149869631105 4006 883298
SGTC_1879 gemcitabine 100 µM -0.950047459806461 0.172069792461216 no 2815 0.171044068986652 3993 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3104 9120930 49.47 µM -0.952199816870258 0.171504196736743 no 2816 0.17049782693801 4061 17014836
SGTC_63 0099-0242 26.702 µM -0.954758751063279 0.170833308551039 no 2817 0.169849855777837 4073 3898502 YLR359W ADE13
SGTC_1873 rapamycin 2 nM -0.954862981895187 0.170806017491206 no 2818 0.169823496045681 4006 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1287 0971-0001 34.6 µM -0.955203383143903 0.170716908685225 no 2819 0.169737427644595 4018 4665869
SGTC_1642 st009582 77.7 µM -0.955836759010813 0.170551185423347 no 2820 0.169577356848217 3997 6739311
SGTC_2691 st077356 60.2 µM -0.956399674043028 0.170403984775882 no 2821 0.169435174675657 4102 2839272
SGTC_81 0411-0046 9.971 µM -0.958589453598705 0.169832138005129 no 2822 0.168882803804598 3988 12925265
SGTC_1524 corynanthine 62.1 µM -0.959747619663426 0.169530188525211 no 2823 0.168591125244062 4173 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_940 3232-1287 54.8 µM -0.959870364861991 0.169498207399369 no 2824 0.168560231445615 3951 1585493 YIL048W NEO1
SGTC_2151 5563267 85.4165 µM -0.960463918058766 0.16934361239505 no 2825 0.168410891109209 4083 5310824
SGTC_3352 9151559 45.5865 µM -0.960833828284428 0.169247312529202 no 2826 0.168317863280628 4047 17159339
SGTC_3314 9135860 59.4275 µM -0.961523994916561 0.169067733337247 no 2827 0.168144383322169 4051 25252478
SGTC_119 0121-0043 24.815 µM -0.961826042629302 0.168989179980259 no 2828 0.168068496955973 4055 1092378
SGTC_2906 7926292 26.41 µM -0.962739468634382 0.168751768529942 no 2829 0.167839142239739 4070 2966319
SGTC_115 0527-0192 112.043 µM -0.964832093697558 0.168208676149575 no 2830 0.16731445911641 4050 4233931
SGTC_1597 7-benzyloxygramine 47.5 µM -0.964993188847212 0.168166914297408 no 2831 0.167274111656305 3988 260807
SGTC_248 streptozotocin 5.23457 mM -0.965533572886609 0.168026875387941 no 2832 0.16713881432109 4066 5300 DNA alkylating agent.
SGTC_3088 9117578 49.47 µM -0.966362865003231 0.16781211282037 no 2833 0.166931319589508 4087 678341
SGTC_1374 2889-5571 141 µM -0.966954606735408 0.167658976997057 no 2834 0.16678336325598 4111 2853281
SGTC_1843 st055809 45.5 µM -0.967424121359518 0.167537536172685 no 2835 0.166666028233887 4120 16413835
SGTC_187 1488-2104 32.728 µM -0.969473547886214 0.167008111924757 no 2836 0.166154485988475 4060 2852859
SGTC_1608 st001473 40.5 µM -0.969567909774575 0.166983761616748 no 2837 0.166130957463551 4027 7292267
SGTC_1488 4013-0813 75.9 µM -0.973802063296461 0.165893485113975 no 2838 0.165077414221064 3992 2910057
SGTC_2414 st077232 92.9 µM -0.974525747351915 0.165707600983558 no 2839 0.164897780711359 4000 729801
SGTC_2802 7925815 54.55 µM -0.975821431843096 0.16537513043428 no 2840 0.16457648108682 4036 1262923
SGTC_2413 inermin 26.06 µM -0.976906355819802 0.165097072921455 no 2841 0.164307757462145 4170 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2005 4024620 188 µM -0.97926324978908 0.164494063023803 no 2842 0.163724961915787 4045 236743
SGTC_1937 st074714 47.2 µM -0.980921479321195 0.164070662583868 no 2843 0.163315732177349 4029 17250970
SGTC_1349 flufenamic acid 69 µM -0.980998274420671 0.164051071417062 no 2844 0.16329679624772 3986 3371 A non-steroidal anti-inflammatory.
SGTC_340 k038-0059 454 µM -0.981395662935426 0.163949718039117 no 2845 0.163198832043428 4050 23733424
SGTC_614 0462-0418 107 µM -0.981800740165869 0.163846445490511 no 2846 0.163099011731067 3855 5188303
SGTC_79 0052-0007 94.094 µM -0.982885883850296 0.163570001252434 no 2847 0.162831803042292 4051 2801472
SGTC_1097 itavastatin 7.23 µM -0.983009347978108 0.16353856752492 no 2848 0.162801418952486 4071 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2206 7254556 146.969 µM -0.983886886691298 0.163315260905088 no 2849 0.162585565991876 4062 4398905
SGTC_171 k064-0041 9.68 µM -0.984102748542314 0.163260361073315 no 2850 0.162532497828396 4098 53325
SGTC_2367 9070478 135.38 µM -0.987233112731035 0.16246556808939 no 2851 0.161764186173544 4030 572802
SGTC_3276 9139060 49.47 µM -0.987333638845558 0.162440086515566 no 2852 0.161739552489548 4154 4870619
SGTC_2497 7-hydroxyflavone 100 µM -0.988176632683512 0.162226505005986 no 2853 0.161533075079851 4106 5281894
SGTC_257 daunorubicin 18.5 µM -0.989448018879152 0.161904731687026 no 2854 0.161221995229015 4096 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_854 0422-0053 192 µM -0.98969438348778 0.161842427745354 no 2855 0.161161760536547 4093 3596728
SGTC_821 1114-0266 29.2 µM -0.989931334400022 0.161782519203684 no 2856 0.161103841291289 4104 3123235
SGTC_13 0199-0087 65 µM -0.99082968755229 0.161555518928199 no 2857 0.160884375154958 4134 4589825
SGTC_893 0958-0369 48.9 µM -0.992921153072533 0.161027842030738 no 2858 0.160374190185986 4019 6819948
SGTC_512 prima-1 270 µM -0.993160803775421 0.16096745004939 no 2859 0.1603157981954 4088 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2105 5350118 200 µM -0.994205338214907 0.160704400013075 no 2860 0.1600614548784 4069 2133313
SGTC_2552 juarezic acid 87.02 µM -0.994401748877516 0.160654968362835 no 2861 0.160013658523315 4071 1549512
SGTC_1518 st038567 90.8 µM -0.995021664035344 0.160499016365841 no 2862 0.159862863959854 4042 77966
SGTC_2419 paclitaxel 166.5 µM -0.995715350313025 0.160324623071049 no 2863 0.159694234789976 4014 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_368 fentichlor 4.58 µM -0.996170524313799 0.1602102592706 no 2864 0.159583649169743 4144 7329 A pesticide.
SGTC_1569 carminic acid 40.6 µM -0.998236734390985 0.159691788562728 no 2865 0.159082288744463 4190 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1761 st044296 37 µM -0.999039480818739 0.159490653182211 no 2866 0.158887783074388 4072 1826700
SGTC_3225 9130819 49.47 µM -1.000109209716 0.159222880777375 no 2867 0.158628829820316 4016 4547121
SGTC_2239 6685329 187.64 µM -1.00030243367237 0.159174544756022 no 2868 0.158582084902698 4141 805680
SGTC_774 k060-0086 136 µM -1.00032387517954 0.159169181639144 no 2869 0.158576898310385 4064 5911235
SGTC_337 1315-0038 354 µM -1.00133716712852 0.158915864131424 no 2870 0.158331914956257 4043 1626437
SGTC_1930 st074634 34.3 µM -1.00176003837021 0.158810226787039 no 2871 0.158229750952241 3998 684253 YOR116C RPO31
SGTC_378 3970-0959 8.33 µM -1.00193077700847 0.158767587663548 no 2872 0.158188513440866 4121 6615653
SGTC_1412 3909-8563 178 µM -1.00336919683287 0.158408664299515 no 2873 0.157841380293967 4166 23767530
SGTC_150 3970-0969 77.2 µM -1.00357682505023 0.158356899624948 no 2874 0.157791314826976 4183 6615640
SGTC_2720 fluspirilene 36.88 µM -1.00366923293789 0.158333864590306 no 2875 0.157769035834034 4100 3396 An atypical antipsychotic.
SGTC_174 3553-0389 74.3 µM -1.00635458637676 0.157665431642011 no 2876 0.157122515510862 4172 738071
SGTC_1294 1000-1494 117 µM -1.00696982643078 0.157512548689814 no 2877 0.156974637217769 4103 712797 YDL207W GLE1
SGTC_1352 1496-0991 99 µM -1.00822167317541 0.157201774196752 no 2878 0.156674027740095 4075 3000039
SGTC_1550 gossypolone 36.6 µM -1.01046574550009 0.15664568675825 no 2879 0.156136101416758 4107 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1777 st045864 34.765 µM -1.0110709177841 0.156495945316884 no 2880 0.155991244229523 4085 4691462
SGTC_2213 7173844 200 µM -1.01140047378685 0.156414440931945 no 2881 0.155912397254183 4061 892728
SGTC_2215 7188065 200 µM -1.01424072771889 0.155713160290805 no 2882 0.15523394952965 4117 940217
SGTC_281 1672-3440 14.9 µM -1.014666756505 0.15560814960054 no 2883 0.155132352917807 4142 6833000
SGTC_168 3970-0862 530.542 µM -1.01581943233709 0.155324263849144 no 2884 0.154857690292583 4076 3135186
SGTC_2876 9059903 25.97 µM -1.01608968078958 0.155257755440466 no 2885 0.154793341294335 4085 6916095
SGTC_1534 6-azauridine 81.6 µM -1.0165729154455 0.155138877781087 no 2886 0.154678322081897 4126 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_146 3448-8650 53.125 µM -1.02077003777444 0.154108897031026 no 2887 0.153681701522176 4099 2891488 YIL048W NEO1
SGTC_1208 2323-2347 50.3 µM -1.02102690200067 0.154046009356562 no 2888 0.153620846626762 4135 5412760
SGTC_618 k072-0232 33.2 µM -1.02109703287992 0.154028842272005 no 2889 0.153604234368109 4154 5872756 YGL099W LSG1
SGTC_2652 actinonin 100 µM -1.02253165244011 0.153677944720644 no 2890 0.153264669780122 4113 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1221 2958-7315 257 µM -1.02331640574244 0.15348622385817 no 2891 0.153079134679248 4146 4562705
SGTC_144 4161-2749 112.381 µM -1.02456083326919 0.153182526197249 no 2892 0.152785226557646 4052 797501 YMR168C CEP3
SGTC_1419 3993-2473 62.6 µM -1.02721769241734 0.152535463721719 no 2893 0.152158984465406 4183 704026
SGTC_891 0929-0073 133 µM -1.028545488614 0.152212767398562 no 2894 0.151846652366659 4158 5603632
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.03120154230229 0.151568623761369 no 2895 0.151223158779364 4129 688669
SGTC_560 2332-1943 155 µM -1.0337845174879 0.150943943544159 no 2896 0.150618455589126 4077 21177716
SGTC_2264 7948757 110.76 µM -1.03529610566185 0.150579169101252 no 2897 0.150265323988676 4087 2971411
SGTC_889 0919-1524 82.7 µM -1.03698680320162 0.150171868385656 no 2898 0.149871003742404 4153 3905452
SGTC_2868 9035608 32.47 µM -1.03715133143299 0.150132271643467 no 2899 0.149832667814707 4101 6462614
SGTC_2232 chlorophetanol 41.5365 µM -1.03890315350342 0.149711095066382 no 2900 0.149424889815382 4197 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2534 helenine 20.12 µM -1.0389751146155 0.149693810903218 no 2901 0.149408155020666 4127 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1046 2001-0062 216 µM -1.04351324581724 0.148606497379468 no 2902 0.148355324664036 4043 739778
SGTC_1900 st060200 72.8 µM -1.04580742768382 0.148058837221548 no 2903 0.147824975573548 4124 688945
SGTC_443 clozapine 122 µM -1.04624288217009 0.147955039562415 no 2904 0.147724454495548 4076 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_398 bronopol 33.3 µM -1.04679916451949 0.147822511492187 no 2905 0.147596107906715 4049 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_566 0958-0068 16.5 µM -1.04760666907228 0.147630274003744 no 2906 0.147409931771684 4055 6815365
SGTC_1316 1272-0050 65.9 µM -1.0478078937428 0.147582395796774 no 2907 0.147363562442079 4094 7340392
SGTC_2833 9001315 45.46 µM -1.04918974480929 0.147253887321941 no 2908 0.147045398809098 4108 2989378
SGTC_2012 4023501 200 µM -1.04943208513903 0.14719632613116 no 2909 0.146989648785793 4171 3477460
SGTC_2372 9071633 200 µM -1.05147076323635 0.146712692179088 no 2910 0.146521215227953 4170 21321366
SGTC_983 1491-0821 12.2 µM -1.05153053745414 0.146698528097326 no 2911 0.146507495852705 4140 46495113
SGTC_2079 5212404 121 µM -1.05244463752837 0.146482037507274 no 2912 0.14629779907234 4121 758462
SGTC_2485 5633444 17.78 µM -1.05314862924168 0.146315454118267 no 2913 0.146136439107037 4153 5724239
SGTC_772 k072-0172 35.3 µM -1.0536401873459 0.146199213688657 no 2914 0.146023841357525 4179 5861980
SGTC_2304 7443016 91.4 µM -1.06440036978479 0.143670253219694 no 2915 0.143573683172697 4086 939854
SGTC_1563 conessine 56.1 µM -1.06665904726114 0.143143168871679 no 2916 0.143062913142977 4239 441082 An anti-amoebic, histamine inhibitor.
SGTC_2438 5259590 200 µM -1.06725730243065 0.143003779305168 no 2917 0.142927831553387 4172 1201127
SGTC_666 0272-0154 136 µM -1.06807225959871 0.142814047191023 no 2918 0.142743958979276 4169 6870312
SGTC_2877 9040724 71.43 µM -1.07237315683265 0.141815564362767 no 2919 0.141776229876871 4163 6463895
SGTC_1594 piperine 70.1 µM -1.07361816681745 0.141527411201641 no 2920 0.141496925970202 4140 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1028 k015-0029 4.8 µM -1.074791728357 0.141256157990337 no 2921 0.141233992299987 4111 4588309
SGTC_1141 3253-0389 52.6 µM -1.08006963947896 0.140040597303679 no 2922 0.140055585198213 4174 5402031
SGTC_1677 st019204 53.9 µM -1.08129599801599 0.139759174145784 no 2923 0.139782733527108 4200 3945625
SGTC_2793 7325131 81.82 µM -1.08323843012302 0.139314214583812 no 2924 0.139351303013649 4134 4176441
SGTC_2911 7942208 15.64 µM -1.08376781631774 0.139193113603921 no 2925 0.139233879147953 4210 1243384
SGTC_534 k292-0788 63.4 µM -1.08790613826411 0.138248911175455 no 2926 0.13831827301933 4239 4146317
SGTC_162 k030-0015 37.8 µM -1.08928283614619 0.137935772995438 no 2927 0.138014589660954 4255 1809920 YMR134W ERG29
SGTC_1484 3473-2379 286 µM -1.09159762116296 0.137410352656659 no 2928 0.137505001098546 4305 671917
SGTC_1765 st044815 90.4 µM -1.09417933623721 0.136825957297122 no 2929 0.136938166174625 4222 645695
SGTC_2900 5328528 85.29 µM -1.09696461520602 0.136197390979936 no 2930 0.136328430300465 4208 795359
SGTC_1177 0983-0204 23.6 µM -1.09778218064688 0.136013263089478 no 2931 0.136149807158414 4220 766818
SGTC_1581 himbacine 57.9 µM -1.10247326323667 0.134960056223138 no 2932 0.135127987984565 4190 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_383 2324-0395 7.37 µM -1.10354299930599 0.13472067241459 no 2933 0.13489571455785 4197 3146421
SGTC_3156 9099931 49.47 µM -1.10468622934161 0.134465164507956 no 2934 0.134647786196848 4228 18111053
SGTC_2705 st078069 42.8 µM -1.10498568881075 0.134398291388232 no 2935 0.134582895173477 4254 1530061
SGTC_1072 oxiconazole 14.9 nM -1.10566178517084 0.13424739443527 no 2936 0.134436468204391 4183 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2871 9038510 12.99 µM -1.105764854441 0.134224400781967 no 2937 0.134414155375892 4163 4945164
SGTC_768 0384-0033 77.3 µM -1.10657055679624 0.134044750412798 no 2938 0.134239821486612 4159 3965305 YMR134W ERG29
SGTC_1706 st031321 9.9705 µM -1.10669238721225 0.134017599830041 no 2939 0.134213473946808 4223 6103185
SGTC_630 4356-0227 183 µM -1.10719163378918 0.133906379436276 no 2940 0.134105541959925 4157 779312
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.10730493209092 0.133881148073501 no 2941 0.134081056333575 4084 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2093 5331342 194.4 µM -1.11059600843669 0.13314965602008 no 2942 0.133371140836488 4263 33839
SGTC_1504 k297-0033 30 µM -1.11218235961167 0.132798049443534 no 2943 0.133029875484922 4078 4388117
SGTC_1321 1326-2144 215 µM -1.11237120265941 0.132756235981549 no 2944 0.132989290511593 4206 3513030
SGTC_449 xestospongin c 11.1929 µM -1.1124872273556 0.132730550392366 no 2945 0.132964359433177 4221 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2484 5809818 12.04 µM -1.11336377956878 0.132536609555779 no 2946 0.132776112201881 4170 2870548
SGTC_1485 3909-9022 254 µM -1.11547717924177 0.132069814201031 no 2947 0.132322996204015 4258 714516
SGTC_947 3447-0010 211 µM -1.11648902224204 0.131846726043401 no 2948 0.132106433304013 4164 748350
SGTC_1018 4259-0013 28.1 µM -1.12268938668303 0.130485365940383 no 2949 0.130784718548732 4267 6801262
SGTC_3113 9123498 49.47 µM -1.12472903066551 0.130039671459297 no 2950 0.130351937961458 4316 8897275
SGTC_1774 st048371 48.465 µM -1.12560083064254 0.129849491178236 no 2951 0.130167258177451 4196 4242727
SGTC_538 2922-0838 53.3 µM -1.12613313819822 0.129733464780994 no 2952 0.13005458463066 4257 777039
SGTC_1118 chelidonine 707.474 nM -1.12748950194822 0.12943814453349 no 2953 0.129767788305129 4215 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1025 k007-0731 70 µM -1.12840228191346 0.129239667918604 no 2954 0.12957503226312 4189 6256118
SGTC_1860 st056228 74.6 µM -1.12933542642146 0.129036981368107 no 2955 0.129378180867729 4204 688679
SGTC_1375 2910-0797 186 µM -1.13053066064613 0.12877768892942 no 2956 0.129126343228549 4232 742508
SGTC_2888 9058547 12.99 µM -1.13110493624641 0.128653235029919 no 2957 0.12900546345496 4118 16476514
SGTC_1289 0976-0073 69.1 µM -1.13263082130671 0.128322959053991 no 2958 0.128684659907317 4288 3391136
SGTC_2294 7971431 200 µM -1.13544465407834 0.127715453149042 no 2959 0.128094529480701 4219 5741572
SGTC_2166 5933061 31.504 µM -1.13573879971794 0.127652062771823 no 2960 0.128032948553439 4372 2877375
SGTC_1633 st005664 67.9 µM -1.13653832380389 0.127479870452798 no 2961 0.127865667940902 4228 2063822
SGTC_458 nppb 133 µM -1.14043219947525 0.126643561405112 no 2962 0.12705314222376 4277 4549 A chloride channel blocker.
SGTC_2750 bromebric acid 70.15 µM -1.14089214387912 0.12654502952993 no 2963 0.126957404539534 4271 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_3256 9138902 49.47 µM -1.141020972793 0.126517440651672 no 2964 0.126930597733597 4331 17228773
SGTC_3035 9091303 49.47 µM -1.14150072672252 0.126414737583945 no 2965 0.126830804874191 4303 25237002
SGTC_1447 4239-0816 81.9 µM -1.14201114523516 0.126305533802882 no 2966 0.126724693508359 4237 1341554
SGTC_753 1322-0200 289 µM -1.14203692531311 0.126300019912904 no 2967 0.126719335705165 4301 5403907
SGTC_736 0958-0254 92.6 µM -1.14270319574334 0.126157574967398 no 2968 0.126580921256673 4316 6812352
SGTC_1687 st020778 55.3625 µM -1.14291751080014 0.126111779402906 no 2969 0.126536420736605 4240 4259299
SGTC_2026 5148700 152 µM -1.14461367873768 0.125749745307956 no 2970 0.126184611718175 4209 79838
SGTC_3318 9139014 38.6185 µM -1.14566474250573 0.125525767934603 no 2971 0.125966948800264 4239 16643984
SGTC_569 4130-2812 160 µM -1.14695909335489 0.125250329798781 no 2972 0.125699263896708 4073 743552
SGTC_2712 st079126 47.7 µM -1.15033098747956 0.124534772488515 no 2973 0.125003786282719 4221 3152970
SGTC_2936 9038235 15.59 µM -1.15134834664849 0.12431943872 no 2974 0.124794477412289 4177 4749415
SGTC_2566 crystal violet carbinol 226 nM -1.15195221251659 0.124191747976217 no 2975 0.124670355482266 4273 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_3087 9117406 49.47 µM -1.15413352411172 0.12373126209999 no 2976 0.124222715531465 4273 42546093
SGTC_2895 9054447 58.44 µM -1.15424527266824 0.123707703647984 no 2977 0.124199813257632 4313 2697450
SGTC_1290 0986-0249 10.2 µM -1.15432883097214 0.123690090221756 no 2978 0.124182690356647 4098 53329
SGTC_2457 5731572 11.68 µM -1.154503842757 0.123653204819265 no 2979 0.124146832014297 4290 2865357
SGTC_2273 7815444 169.05 µM -1.15547063828088 0.123449582240869 no 2980 0.123948874836032 4209 2824616
SGTC_1647 st011722 22.4 µM -1.15824972541376 0.122865570494347 no 2981 0.123381070648633 4219 2854783
SGTC_629 3448-6466 76.7 µM -1.16562232116034 0.121325651057821 no 2982 0.121883589522728 4251 573744
SGTC_391 gliotoxin 8.33 µM -1.16600754913048 0.121245562978473 no 2983 0.121805696644496 4341 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2075 5212009 200 µM -1.16670337396883 0.121100996713048 no 2984 0.121665089906363 4170 780898
SGTC_1963 st076565 50.3 µM -1.17053574739348 0.120306946536678 no 2985 0.120892718573783 4277 4914280
SGTC_3178 9107506 49.47 µM -1.17520477405549 0.119344511104868 no 2986 0.119956400361465 4251 8897194
SGTC_87 0100-0052 35.5 µM -1.17683216154145 0.119010334967746 no 2987 0.119631251527099 4302 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_488 nitrendipine 139 µM -1.17712893867013 0.118949464523689 no 2988 0.119572023118061 4294 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1643 st009866 20.2 µM -1.17950874590237 0.11846214933632 no 2989 0.119097828094143 4222 3156273 YOR207C RET1
SGTC_707 0865-0008 204 µM -1.18213225145221 0.117926568977742 no 2990 0.118576614590644 4298 723043
SGTC_2110 5483698 200 µM -1.18367922370647 0.117611563537454 no 2991 0.118270033150605 4254 2848765 YHR062C RPP1
SGTC_825 1988-2224 89.6 µM -1.18455146477566 0.11743421446305 no 2992 0.118097418311917 4253 1180859
SGTC_2396 5342950 42.78 µM -1.1883124414359 0.11667167985199 no 2993 0.117355168938051 4245 1886677
SGTC_818 4072-2707 53.5 µM -1.19271160736764 0.115784216006294 no 2994 0.116491169080313 4178 882871
SGTC_1859 st055998 20 µM -1.19417690462176 0.115489682001851 no 2995 0.116204387663017 4247 676301
SGTC_2920 7982904 15.77 µM -1.19458691956225 0.115407361817796 no 2996 0.116124231161463 4286 6456808
SGTC_3312 9133330 71.43 µM -1.19580420497236 0.115163208720906 no 2997 0.115886487304682 4319 17617324
SGTC_3224 9130643 49.47 µM -1.19678933573231 0.11496588832382 no 2998 0.115694337963866 4354 17644395
SGTC_2033 5192550 145 µM -1.19795272262025 0.11473317326106 no 2999 0.115467711401877 4281 182073
SGTC_795 0685-0265 78 µM -1.20034409471059 0.114255874381648 no 3000 0.115002865621851 4293 302754
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.20512244349972 0.113306393141717 no 3001 0.11407801840071 4314 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2261 9010538 184.68 µM -1.20519616874497 0.113291787797931 no 3002 0.114063790537051 4297 6457250
SGTC_3173 9105693 49.47 µM -1.20964680987712 0.112412579565543 no 3003 0.113207224035874 4292 17096658
SGTC_1945 st075991 56.6 µM -1.21408202293573 0.111541279399087 no 3004 0.112358202032428 4281 1084980
SGTC_1546 5-methoxyflavanone 78.7 µM -1.21444200239751 0.111470773840194 no 3005 0.11228949219858 4306 147795
SGTC_1666 st014829 29 µM -1.2159797785464 0.11116994422519 no 3006 0.111996312609815 4287 3858230
SGTC_1788 fluconazole 20 µM -1.21638185573854 0.111091383267316 no 3007 0.111919746260941 4322 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_493 zm226600 134 µM -1.21731465984165 0.110909277901429 no 3008 0.111742259351377 4321 5240098 A potassium channel opener. YCR052W RSC6
SGTC_779 1360-0071 233 µM -1.21933053683852 0.110516461815236 no 3009 0.111359381433588 4344 7566
SGTC_963 1269-2853 151 µM -1.22096435898903 0.110198825870387 no 3010 0.111049757312146 4278 3668223
SGTC_1013 4112-3890 241 µM -1.2218579082979 0.110025385684388 no 3011 0.110880682646867 4244 705171
SGTC_1893 st059353 36.1 µM -1.22275995815851 0.109850494265909 no 3012 0.110710186667368 4321 3112488
SGTC_1047 2043-3044 82 µM -1.22544052072996 0.109331958506553 no 3013 0.110204643776073 4286 669592
SGTC_2735 sertaconazole 140 nM -1.22671034137393 0.109086935437858 no 3014 0.109965739736426 4443 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2864 9034755 47.6 µM -1.22743791512217 0.108946721643691 no 3015 0.109829021603038 4237 4930451
SGTC_1240 0356-0016 42.1 µM -1.23442461097171 0.107606877730753 no 3016 0.108522361456554 4281 4305613
SGTC_802 4112-3352 742 µM -1.23481686752728 0.107532007964418 no 3017 0.108449334153222 4371 704594
SGTC_909 3448-9333 149 µM -1.23783208547929 0.106957748290269 no 3018 0.107889164350357 4247 3344074
SGTC_2299 7976368 114.88 µM -1.23808728712064 0.106909245910529 no 3019 0.107841848593835 4334 2979718
SGTC_3346 9158254 43.5805 µM -1.23971111266276 0.106601001210938 no 3020 0.107541132682786 4324 17639500
SGTC_2359 9039622 200 µM -1.23973147278265 0.106597140402398 no 3021 0.107537366036203 4279 6463596
SGTC_2993 9054257 71.4286 µM -1.23992194136042 0.106561027492328 no 3022 0.107502133725802 4238 6470217 YGL055W OLE1
SGTC_1696 st025591 34.7925 µM -1.24073124917494 0.106407680931136 no 3023 0.107352523146189 4324 2787147
SGTC_3121 9125696 49.47 µM -1.24367016364963 0.105852159394825 no 3024 0.106810490663618 4434 1235365
SGTC_2314 7727897 200 µM -1.24626774860892 0.105362904671322 no 3025 0.106333057011853 4301 900724
SGTC_2099 5377090 177.372 µM -1.25164460945679 0.104355375850427 no 3026 0.105349695938941 4345 2243829
SGTC_1421 4029-0249 71.4 µM -1.2536559709929 0.103980282300429 no 3027 0.104983538888544 4417 2894095
SGTC_1128 3448-9350 235 µM -1.25477057937721 0.103772843389794 no 3028 0.104781027844407 4352 619386
SGTC_1710 st031758 61.5 µM -1.25573351820319 0.103593873434184 no 3029 0.104606301234827 4368 5394341
SGTC_2714 st079313 56.9 µM -1.2615751031186 0.102512966920079 no 3030 0.103550859790324 4314 2939799
SGTC_2016 5121758 140 µM -1.26250295680246 0.102342037510427 no 3031 0.103383931506236 4274 2795203
SGTC_3089 9117425 49.47 µM -1.2637142039677 0.102119213316592 no 3032 0.103166312537624 4317 9401657
SGTC_3303 9125618 40.5795 µM -1.26394116514426 0.102077500239718 no 3033 0.103125572544808 4355 22695467
SGTC_3131 9127911 49.47 µM -1.26499835482589 0.101883363256516 no 3034 0.102935958809592 4367 45595681
SGTC_283 0987-0079 11.7 µM -1.26583584850374 0.101729761011439 no 3035 0.102785928853924 4330 411556
SGTC_808 0711-0032 135 µM -1.27201587924641 0.100601509479208 no 3036 0.101683738688452 4318 4252555
SGTC_2170 morpholine 200 µM -1.27347841993709 0.100335842900192 no 3037 0.101424162756091 4380 121171 Reacts with secondary amines.
SGTC_1333 1482-0047 286 µM -1.27359703377298 0.100314319483549 no 3038 0.10140313201064 4355 3811116
SGTC_1286 0929-0070 131 µM -1.27460032870683 0.100132398482721 no 3039 0.10122537054612 4422 1420408
SGTC_2974 9094440 9.66 µM -1.27624283600309 0.0998350933509344 no 3040 0.100934845257839 4333 25236134
SGTC_1042 0350-0096 82 µM -1.27631265516954 0.0998224699031337 no 3041 0.100922509186643 4344 3122515
SGTC_1494 4358-1428 177 µM -1.27799161366953 0.0995192618219808 no 3042 0.100626191633671 4367 1564571
SGTC_201 4262-0159 12.803 µM -1.27846426379959 0.0994340260775569 no 3043 0.100542888716131 4378 1341029
SGTC_1476 4112-3294 3.34 µM -1.28316574031798 0.0985890853201869 no 3044 0.0997170079491962 4340 704369
SGTC_120 rhodamine 6G 52.259 µM -1.28384395287956 0.0984676332861606 no 3045 0.0995982805757884 4364 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_3191 9110352 49.47 µM -1.28579929426744 0.0981180905737269 no 3046 0.0992565582998861 4308 17122424
SGTC_712 r015-0009 80.6 µM -1.2875481844951 0.0978062246171472 no 3047 0.0989516431305298 4377 6813872 YLR060W FRS1
SGTC_2755 lomerizine 42.69 µM -1.2882907608977 0.097674026747696 no 3048 0.0988223840246801 4308 3949 A calcium channel blocker.
SGTC_2265 7929201 200 µM -1.29014803995425 0.0973439565912051 no 3049 0.0984996314349703 4339 1265108
SGTC_1738 st035555 74 µM -1.29436272522041 0.0965979720310319 no 3050 0.0977700797805587 4399 5331140
SGTC_2846 9008642 19.48 µM -1.29525734871522 0.0964401685320724 no 3051 0.0976157336120854 4388 2992898
SGTC_2316 5844804 197.44 µM -1.29719480257461 0.0960990686511259 no 3052 0.0972820842925042 4363 776813
SGTC_549 1661-1316 519 µM -1.29735786505358 0.0960704010844314 no 3053 0.0972540414912765 4389 2857282
SGTC_3213 9129884 49.47 µM -1.29773919219237 0.0960033855537929 no 3054 0.0971884856041377 4343 17190742
SGTC_3102 9121669 49.47 µM -1.29880456451692 0.0958163361442982 no 3055 0.0970055038979407 4404 41905072
SGTC_520 3584-0023 682 µM -1.30102673752974 0.095427048071641 no 3056 0.096624651425173 4377 1340790
SGTC_3264 9137442 49.47 µM -1.30127041242935 0.0953844311802523 no 3057 0.0965829555328024 4350 17015726
SGTC_507 nimesulide 162 µM -1.30193935232053 0.0952675106946534 no 3058 0.0964685593110046 4415 4495 A COX2 inhibitor.
SGTC_2260 7964312 200 µM -1.3027890944512 0.0951191409416744 no 3059 0.0963233874730156 4421 231951
SGTC_936 3005-4620 401 µM -1.30531925826557 0.0946783679717437 no 3060 0.0958920795236695 4404 777207
SGTC_68 0986-0284 82.829 µM -1.3116314304229 0.0935853074926532 no 3061 0.0948222614136408 4382 423278 YIL048W NEO1
SGTC_918 glabranin 770.725 nM -1.31345100284349 0.0932719545018527 no 3062 0.0945155104691699 4376 124049 Also referred to as licorice root.
SGTC_2909 7941780 10.49 µM -1.3134588950242 0.0932705970607787 no 3063 0.0945141815685473 4343 1243215
SGTC_3099 9120367 49.47 µM -1.3162777116571 0.0927866987280611 no 3064 0.0940404244308412 4415 24824940
SGTC_3253 9135987 49.47 µM -1.3195732070165 0.0922233271998427 no 3065 0.0934887766224317 4378 4182430
SGTC_2031 5180455 200 µM -1.3233040089334 0.0915885994300744 no 3066 0.0928671495301282 4371 29949
SGTC_389 tpck 16.7 µM -1.32420138568673 0.0914364112760937 no 3067 0.0927180853907479 4423 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3025 9087895 49.47 µM -1.32610005262648 0.0911150300413053 no 3068 0.0924032793598085 4348 17173641
SGTC_409 arachidonic acid 100 µM -1.32759738406972 0.0908621729962635 no 3069 0.0921555746025503 4371 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_3341 9147222 25.867 µM -1.32876915666924 0.0906646570885092 no 3070 0.0919620704380392 4385 1939759
SGTC_27 0485-0001 32.618 µM -1.32930375963916 0.0905746494715656 no 3071 0.0918738872016376 4382 2054479
SGTC_1153 4055-0057 267 µM -1.33138272102355 0.0902252587881126 no 3072 0.0915315559807763 4433 882706
SGTC_626 0214-0009 33 µM -1.33384323718299 0.089813038672876 no 3073 0.0911276187832139 4441 3437874
SGTC_262 fenpropimorph 62.5 µM -1.33435116300232 0.0897281184237755 no 3074 0.0910443986572222 4418 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_413 propylparaben 100 µM -1.33452444689064 0.0896991607060574 no 3075 0.0910160201927955 4376 7175 A pharmaceutical preservative.
SGTC_2444 5485484 36.41 µM -1.3355922356278 0.0895208743102036 no 3076 0.0908412946693856 4453 6790631
SGTC_26 0302-0163 425.158 µM -1.34077524863782 0.0886592206554293 no 3077 0.0899967173264539 4453 3100915
SGTC_3055 9094636 49.47 µM -1.34338403414441 0.088227865327221 no 3078 0.0895738269953319 4428 25236176
SGTC_2338 7999974 200 µM -1.34476674341193 0.0879998734699123 no 3079 0.0893502865644402 4386 315925
SGTC_2943 9068529 45.32 µM -1.34535058535539 0.087903737090151 no 3080 0.089256022468479 4368 3270634
SGTC_2234 tolnaftate 200 µM -1.34589288498108 0.0878145113218501 no 3081 0.0891685318812311 4494 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1912 st060209 90.8 µM -1.34637820774416 0.087734717380256 no 3082 0.0890902876440333 4381 688787
SGTC_127 0180-0333 59.125 µM -1.34929879558269 0.0872556731719243 no 3083 0.0886205061720606 4309 771601
SGTC_492 tmb-8 126 µM -1.34933138285199 0.0872503391419254 no 3084 0.0886152748838396 4420 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1572 epiandrosterone 68.9 µM -1.3600960793166 0.085501618323615 no 3085 0.0868997608105519 4345 441302 A steroid.
SGTC_3109 9122853 49.47 µM -1.36709314944208 0.0843791056645786 no 3086 0.0857980551364554 4444 1234709
SGTC_2116 5511452 16.8835 µM -1.36872692638457 0.0841186048047189 no 3087 0.0855423250895634 4427 870744
SGTC_2227 7312221 64.1025 µM -1.36945819876857 0.0840022013888276 no 3088 0.0854280463814752 4534 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2214 7179297 48.276 µM -1.36977031704947 0.0839525554675149 no 3089 0.0853793053074373 4488 769744
SGTC_1344 1488-0097 29.1 µM -1.37035476188696 0.0838596522061965 no 3090 0.0852880931494776 4444 747966
SGTC_1376 2910-0861 41.3 µM -1.37103695185142 0.0837513090825988 no 3091 0.0851817186292013 4359 1112859
SGTC_2092 5303694 80.6725 µM -1.37295464278126 0.0834473110916743 no 3092 0.0848832238422194 4422 1963699
SGTC_3054 9094397 49.47 µM -1.37382056832242 0.0833103141313554 no 3093 0.0847486970118257 4415 2598354
SGTC_454 lyso-paf C-16 6.67 µM -1.37392679342443 0.0832935200448533 no 3094 0.0847322053078026 4435 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2085 5307070 144.047 µM -1.38258580381743 0.0819330821470461 no 3095 0.0833959522020761 4365 2840351
SGTC_1236 0330-0013 258 µM -1.38276001397561 0.0819058844320554 no 3096 0.0833692316861397 4436 4617066
SGTC_2394 5221648 200 µM -1.38426028199835 0.0816719438969049 no 3097 0.0831393854743953 4445 788586
SGTC_2733 amorolfine 100 µM -1.39249368884571 0.0803970485013233 no 3098 0.0818864757274735 4589 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2815 7968870 71.43 µM -1.39306448909095 0.0803092239041932 no 3099 0.0818001451372152 4369 2977326 YHR190W ERG9
SGTC_2857 9024691 58.44 µM -1.39765796184836 0.0796050994229448 no 3100 0.0811079018716795 4463 16478292
SGTC_720 r052-1644 49.9 µM -1.39852334068085 0.0794729716581972 no 3101 0.0809779843072295 4446 1422863 YOR257W CDC31
SGTC_2961 9083290 32.55 µM -1.3998605144221 0.0792691357583482 no 3102 0.0807775460951006 4376 17741490
SGTC_2240 6690706 185.951 µM -1.40030678083516 0.0792011960244966 no 3103 0.0807107355801918 4328 805876
SGTC_1844 rapamycin 4 nM -1.40081916088786 0.0791232455100567 no 3104 0.0806340786664763 4280 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1235 benzylparaben 21.5 µM -1.40084111491077 0.0791199068513964 no 3105 0.0806307953654452 4467 7180
SGTC_2357 9067248 200 µM -1.40114834548358 0.0790731959451065 no 3106 0.0805848585501947 4382 9150235
SGTC_3145 9085516 49.47 µM -1.40439078675667 0.0785814922829881 no 3107 0.0801012564472141 4411 25236195
SGTC_1623 st003709 20.3 µM -1.40529844264271 0.078444265819575 no 3108 0.079966275635737 4406 16192618
SGTC_2728 chlorpromazine 9.18 µM -1.40706295592862 0.0781780130170136 no 3109 0.0797043607239848 4528 2726 A thorazine and dopamine antagonist.
SGTC_237 nikkomycin 200 µM -1.40837251676339 0.0779808529319421 no 3110 0.0795103964390798 4467 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_311 1315-0136 58 µM -1.41142495661793 0.0775227596430408 no 3111 0.0790596742646119 4458 6759207
SGTC_490 phenamil 164 µM -1.41774081760946 0.0765814024840176 no 3112 0.078133224221235 4451 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2113 5491891 107.031 µM -1.42061817776921 0.0761554355872793 no 3113 0.0777138955062975 4436 789979
SGTC_3323 9138564 53.9225 µM -1.42077078437981 0.0761328940357292 no 3114 0.0776917033589938 4448 43912313 YNL103W MET4
SGTC_2904 7225135 42.03 µM -1.42237123387445 0.0758967971786078 no 3115 0.0774592547156758 4507 4446116
SGTC_1905 st060207 84.5 µM -1.4246405424881 0.0755629871364007 no 3116 0.0771305671442087 4442 1948547
SGTC_1819 st053448 58.6 µM -1.43252770470893 0.0744115011428802 no 3117 0.0759964275826658 4385 2857616
SGTC_1665 st014639 11.4 µM -1.43408931333365 0.0741851113647152 no 3118 0.0757733885765322 4529 981133 YIL048W NEO1
SGTC_2465 5809242 33.21 µM -1.44190138102473 0.0730604704421976 no 3119 0.0746650982840342 4529 2731748
SGTC_306 1672-3436 11.6 µM -1.44310767006275 0.0728879797726742 no 3120 0.0744950715141645 4467 6797378
SGTC_1993 st073995 70.8 µM -1.44464791079705 0.0726681897735367 no 3121 0.0742784039879541 4480 3098394
SGTC_3187 9109394 49.47 µM -1.44519683223878 0.0725899823171762 no 3122 0.0742013029696174 4460 17098090
SGTC_450 aminopyrene 156 nM -1.44555092222828 0.0725395676427373 no 3123 0.0741516002457174 4413 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_5 0352-0601 109.883 µM -1.4487508830818 0.0720851788240337 no 3124 0.0737035824646218 4373 762456
SGTC_141 0443-0274 32.331 µM -1.45305416412919 0.0714775646357232 no 3125 0.0731043579773427 4405 1627241
SGTC_1014 4130-3005 69.3 µM -1.45463018974252 0.071256019131342 no 3126 0.0728858342573998 4486 743608
SGTC_2054 5233173 129 µM -1.45534142193252 0.0711562124019095 no 3127 0.0727873823098071 4473 6889
SGTC_2051 5263410 176 µM -1.45613545407162 0.0710449132644515 no 3128 0.0726775891495779 4433 227584
SGTC_812 4251-0442 148 µM -1.45670622303389 0.070964991458109 no 3129 0.0725987456270446 4497 5723007
SGTC_885 0865-0106 16.8 µM -1.45703483453678 0.0709190090352618 no 3130 0.072553382399368 4439 2793380
SGTC_321 4534-3890 65.3 µM -1.45783881170651 0.0708066054604926 no 3131 0.0724424887838155 4471 699746
SGTC_1715 st032160 10.2275 µM -1.45812459869145 0.0707666827427015 no 3132 0.0724031011119824 4386 5289825
SGTC_495 decylubiquinone 155 µM -1.46175881706671 0.0702605115833716 no 3133 0.0719036565855938 4472 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_62 0180-0423 3.232 µM -1.4630279428394 0.0700844061653108 no 3134 0.0717298665430108 4433 30102 YGL099W LSG1
SGTC_2228 7354201 200 µM -1.46342571445092 0.0700292808468433 no 3135 0.0716754633363297 4562 753451
SGTC_3051 9093778 49.47 µM -1.46816437835569 0.0693751346900769 no 3136 0.0710297888532008 4570 17217378
SGTC_2408 sulbentine 18.36 µM -1.46948535375743 0.0691936228679948 no 3137 0.070850595754015 4356 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1108 betulinic acid 729.144 nM -1.47496705718958 0.0684443036975618 no 3138 0.0701107001464626 4477 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.47622010979782 0.0682739005107648 no 3139 0.0699424063447296 4462 688761
SGTC_1831 st055328 12 µM -1.47706476780988 0.0681592199465843 no 3140 0.0698291383232419 4469 1103068
SGTC_289 k017-0060 526 µM -1.48308250030306 0.0673464814228125 no 3141 0.0690262464211949 4468 5512909
SGTC_956 1185-0240 191 µM -1.48377035458624 0.06725406079954 no 3142 0.0689349271788028 4463 1416193
SGTC_1512 0259-0544 12.2 µM -1.48469174287614 0.0671304160490779 no 3143 0.0688127500154835 4452 18476
SGTC_1996 st072960 66.8 µM -1.48713752260997 0.0668030597330596 no 3144 0.0684892465324584 4516 1719405
SGTC_1986 st071812 45 µM -1.48940493007802 0.0665006822887677 no 3145 0.0681903855634324 4423 11838594
SGTC_2124 5246320 200 µM -1.49446674022831 0.065829472020511 no 3146 0.0675268344128094 4499 579342
SGTC_1228 0124-0032 52.5 µM -1.4953445441536 0.0657136088607024 no 3147 0.0674122727387689 4515 X1228
SGTC_3092 9117248 49.47 µM -1.49920380591922 0.0652060913611427 no 3148 0.0669103840038329 4607 17141857
SGTC_2098 5376439 882.5 nM -1.50089834301393 0.0649842120806223 no 3149 0.0666909284145282 4544 2844116
SGTC_1648 st011736 69.8 µM -1.50447282915246 0.0645180983883435 no 3150 0.0662298321404997 4478 2855514
SGTC_3275 9138069 49.47 µM -1.51308034447605 0.0634063353761427 no 3151 0.0651296258388881 4550 17617007
SGTC_1181 1222-0449 220 µM -1.52195360088139 0.0622759171208967 no 3152 0.0640103535697263 4546 658318
SGTC_1466 k213-0079 57.5 µM -1.52371611799291 0.062053261945206 no 3153 0.0637898206727775 4495 3657981
SGTC_1049 3226-0134 66 µM -1.52578675212895 0.0617924770204202 no 3154 0.0635314905224293 4536 5702385
SGTC_224 benfluorex 43.875 µM -1.52669299187297 0.0616786106339864 no 3155 0.0634186854475629 4515 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1910 st062352 60.4 µM -1.52832535368598 0.0614739225067345 no 3156 0.0632158890134152 4422 2245730
SGTC_342 k048-0088 23.3 µM -1.53310476342211 0.060877664060182 no 3157 0.062625022112803 4507 6820570
SGTC_2792 7535235 81.82 µM -1.5352188543936 0.0606153659568958 no 3158 0.0623650392570842 4482 1281891
SGTC_2111 5486399 200 µM -1.53558548676375 0.060569967472186 no 3159 0.0623200379654887 4479 689674
SGTC_2386 9075165 157.42 µM -1.5380565324959 0.060264682132106 no 3160 0.0620173964103726 4497 16452277
SGTC_2487 5918373 44.05 µM -1.54371298895531 0.0595703896914706 no 3161 0.0613289391196124 4572 2876279
SGTC_1865 st057639 52.2 µM -1.55195031840778 0.0585705426887157 no 3162 0.0603370558052576 4527 688818
SGTC_2287 7945887 168.79 µM -1.55365430054665 0.0583653674102512 no 3163 0.0601334496824778 4536 1245853
SGTC_1807 st050092 58.9 µM -1.55367217519324 0.0583632181324603 no 3164 0.0601313167238237 4526 5008496
SGTC_2673 kobusone 100 µM -1.55520659776341 0.0581789481589324 no 3165 0.0599484367391786 4621 6710676 An epoxy ketone and protein crosslinker.
SGTC_2855 9016525 58.44 µM -1.56277961291071 0.0572761855756833 no 3166 0.0590522205171831 4463 43811474
SGTC_1036 k216-0215 33.5 µM -1.56420654678011 0.0571073247174835 no 3167 0.0588845351250345 4486 622330
SGTC_2149 5554786 194.827 µM -1.56450704852874 0.0570718138696225 no 3168 0.0588492694909839 4563 745063 YPR165W RHO1
SGTC_533 1222-0222 6.71 µM -1.56453234893935 0.0570688248668393 no 3169 0.058846301096739 4542 3982874
SGTC_1622 st003707 19.4 µM -1.56461649673158 0.057058884492382 no 3170 0.0588364292238713 4538 10140899
SGTC_586 0957-0265 8.15 µM -1.56537452233221 0.0569694004002727 no 3171 0.0587475593518166 4442 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1981 st071826 47 µM -1.56747713054074 0.0567217680680916 no 3172 0.0585016038440504 4567 11838600
SGTC_1588 farnesol 29.9 µM -1.56973515871231 0.0564567763824532 no 3173 0.0582383690519452 4540 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1833 st055984 71 µM -1.57111235850009 0.0562956342340873 no 3174 0.0580782762323904 4567 676288
SGTC_2636 apigenin dimethyl ether 100 µM -1.57636285638497 0.0556846126978302 no 3175 0.0574711016767935 4504 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_830 4076-0286 57.8 µM -1.57965010286179 0.0553047346859915 no 3176 0.0570935092155888 4588 6866659
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.58094809115378 0.0551553024450103 no 3177 0.0569449535365356 4550 616764
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.58513785381851 0.0546751272393794 no 3178 0.0564675083264734 4513 97141
SGTC_1852 st056254 31.4 µM -1.58525859335977 0.0546613388219648 no 3179 0.0564537963391462 4500 442583
SGTC_1943 st076331 65.2 µM -1.58941457271674 0.0541884011502725 no 3180 0.0559834133508118 4530 24208415
SGTC_952 1185-0122 232 µM -1.59515974822448 0.0535399567790372 no 3181 0.0553382586610357 4505 678600
SGTC_3324 9138759 60.749 µM -1.60125070311349 0.0528592149185835 no 3182 0.0546607014169109 4554 45595710
SGTC_2643 anethole 100 µM -1.60244650941631 0.0527263781025932 no 3183 0.054528453535818 4559 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2757 clomiphene 4.22 µM -1.61121439169753 0.0517604669544245 no 3184 0.0535665010402159 4552 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2783 7738165 71.43 µM -1.61179221971828 0.0516973079791777 no 3185 0.0535035808992056 4535 17201110
SGTC_2572 astragaloside iv 100 µM -1.61676003481697 0.0511568296815129 no 3186 0.0529650446469969 4515 45006101 An anti-inflammatory agent.
SGTC_505 gw-5074 63.9 µM -1.61762709543704 0.0510629594915524 no 3187 0.0528714930711511 4559 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1262 0737-0114 49.6 µM -1.61917532165698 0.0508956855559687 no 3188 0.052704773102091 4566 765919
SGTC_1627 st003713 25.6 µM -1.62787270625439 0.0499640937008175 no 3189 0.0517759399258831 4554 16195070 YER133W GLC7
SGTC_1670 st016595 4.04 µM -1.63315594754898 0.0494048685557569 no 3190 0.0512181011544494 4596 597879
SGTC_2153 5569715 200 µM -1.63502724575488 0.0492079962584549 no 3191 0.0510216680900454 4580 2054701
SGTC_2688 kanamycin b 96.69 µM -1.63571078534614 0.0491362400216887 no 3192 0.0509500655771493 4523 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_3223 9129970 49.47 µM -1.64164485280485 0.048516803239365 no 3193 0.0503318132867617 4575 17248386
SGTC_497 capsazepine 133 µM -1.65422460174022 0.0472242983444303 no 3194 0.0490409429888569 4519 2733484 A calcium channel blocker.
SGTC_1928 4'-methoxychalcone 40.3 µM -1.66289617456902 0.0463495171662763 no 3195 0.0481666101412926 4565 641818
SGTC_17 0960-0276 49.807 µM -1.6646895899523 0.0461702325719147 no 3196 0.0479873504681731 4570 6821114
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.66610939434139 0.0460286925715766 no 3197 0.0478458138784199 4643 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1165 k072-0275 30.3 µM -1.66786786461439 0.045853874475665 no 3198 0.0476709800977857 4572 6153523 YGL055W OLE1
SGTC_949 1165-0505 146 µM -1.67138998325415 0.0455053282440628 no 3199 0.0473223365689635 4551 6244267
SGTC_811 0416-0114 265 µM -1.67156198699655 0.045488361593199 no 3200 0.0473053629261311 4585 6612453
SGTC_2018 5133068 143 µM -1.67161221268131 0.0454834082324628 no 3201 0.0473004074844844 4550 785362
SGTC_2152 5568786 200 µM -1.68165347346977 0.0445017973339888 no 3202 0.0463180274912052 4611 5399883
SGTC_191 3914-0123 66.505 µM -1.68588259720078 0.0440935087446233 no 3203 0.0459092072584421 4646 3144412
SGTC_3159 9100096 49.47 µM -1.68766948171335 0.0439219092259648 no 3204 0.0457373466219751 4537 25236875
SGTC_982 1491-0518 27.5 µM -1.69197150126153 0.0435109831447981 no 3205 0.0453257037718781 4548 3091256
SGTC_2231 micatex 6.853 µM -1.69400777006977 0.0433175650268329 no 3206 0.0451319032809627 4605 20737 An antifungal of unknown mechanism.
SGTC_2640 pentamidine 10.38 µM -1.70358851998803 0.0424168211850973 no 3207 0.04422899384288 4538 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2058 5236698 133 µM -1.70548843870775 0.0422400110999362 no 3208 0.0440516833443415 4559 766665
SGTC_1709 st033179 39.1045 µM -1.7141294093479 0.0414433754681114 no 3209 0.0432524808322814 4607 573381
SGTC_2623 humulene 100 µM -1.71433426880241 0.0414246376679282 no 3210 0.0432336764446479 4566 6187145 An anti-inflammatory.
SGTC_2258 7960471 200 µM -1.71746261863622 0.0411393501195136 no 3211 0.0429473394386066 4599 2974708
SGTC_1057 3448-5381 134 µM -1.7218876764169 0.0407385328523072 no 3212 0.0425449339041429 4588 5497911
SGTC_741 4582-0002 126 µM -1.72633156669944 0.0403392047495985 no 3213 0.0421438897393544 4618 2912688
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.72724596568831 0.0402574324589202 no 3214 0.0420617494344108 4619 23665772 A membrane-active detergent.
SGTC_1222 0366-0074 1.18 µM -1.7292135517565 0.040081932950465 no 3215 0.0418854409060992 4606 286520
SGTC_2916 7875993 68.79 µM -1.73198721408913 0.0398355915069487 no 3216 0.0416379194842311 4517 1299250
SGTC_1909 st060837 51.5 µM -1.73333964971225 0.0397159227324199 no 3217 0.0415176586807949 4536 678937
SGTC_1966 st070145 16.1 µM -1.73843670860488 0.0392675392400752 no 3218 0.0410669466037331 4581 3748532
SGTC_2607 solasodine 47.35 µM -1.74312255877938 0.0388589720891981 no 3219 0.0406561044431163 4546 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2931 9014674 55.67 µM -1.74628563987621 0.0385851400987703 no 3220 0.040380664948564 4557 2996810
SGTC_1955 wogonin 32.4 µM -1.74756810223028 0.0384745646327799 no 3221 0.0402694213827426 4580 5281703 A flavanone.
SGTC_1609 st001574 46.4 µM -1.75336719253807 0.0379777801293266 no 3222 0.039769499322083 4602 3960012
SGTC_2972 9093619 59.92 µM -1.7674030774709 0.0367970220629931 no 3223 0.0385803739637363 4581 25236256
SGTC_1185 1319-0113 81.3 µM -1.77113726036579 0.0364879937086146 no 3224 0.038268939619509 4651 4672763
SGTC_261 5-fluorouridine 15.376 µM -1.77770836515153 0.0359493494855105 no 3225 0.037725882543577 4624 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1994 st072947 40.9 µM -1.77959015167178 0.0357963017302833 no 3226 0.0375715295608606 4649 5286565 YDL195W SEC31
SGTC_1659 st012954 42.1 µM -1.77980082577377 0.0357792006567338 no 3227 0.0375542812217807 4612 24207262
SGTC_2800 7887935 81.82 µM -1.78311319107312 0.0355112046302716 no 3228 0.0372839397881371 4597 2961002
SGTC_2157 5649910 96.377 µM -1.79109396349995 0.0348722534968322 no 3229 0.0366391088495136 4603 2858091
SGTC_1238 0333-0287 48.8 µM -1.80321300393792 0.0339200605863995 no 3230 0.0356773844961616 4631 7226
SGTC_229 benomyl 22.8748 µM -1.81500017839883 0.0330145604579269 no 3231 0.0347619410352911 4651 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2621 lithochol-11-enic acid 100 µM -1.81630429894757 0.0329156122384749 no 3232 0.0346618530865169 4576 6708711
SGTC_6 0844-0013 19.835 µM -1.81742752302857 0.0328305853118958 no 3233 0.0345758383022827 4714 1584900
SGTC_2826 7992541 19.48 µM -1.81995146036578 0.0326401862332241 no 3234 0.034383198575802 4623 2985066
SGTC_542 3381-0244 89.3 µM -1.82453272249464 0.0322969148496372 no 3235 0.0340357869948358 4640 1112843
SGTC_1193 1488-0126 41.5 µM -1.83344623253063 0.0316375671777664 no 3236 0.0333681187823141 4625 1384710
SGTC_2040 5100729 123 µM -1.84317989005079 0.0309302986224798 no 3237 0.0326513750142339 4667 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_3259 9138485 49.47 µM -1.8442315973741 0.0308546687937637 no 3238 0.03257469766967 4610 17646153
SGTC_714 4296-0578 26.1 µM -1.84476793086766 0.0308161592339343 no 3239 0.0325356521567866 4675 1589775
SGTC_1121 fusaric acid 630.51 nM -1.84763866508344 0.0306107120124171 no 3240 0.0323273161725266 4617 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_384 k007-0144 5.16 µM -1.853806093208 0.030173168202778 no 3241 0.0318834532230224 4616 6824886
SGTC_366 0181-0206 4.31 µM -1.85893219968018 0.0298134570618323 no 3242 0.0315183746427796 4614 274874
SGTC_3309 9129340 25.759 µM -1.86098761948635 0.0296702260181312 no 3243 0.0313729625314272 4622 17158987
SGTC_1880 MG-132 525 µM -1.86200546650601 0.0295995094618557 no 3244 0.0313011598519596 4613 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_3267 9137951 49.47 µM -1.86440624014065 0.0294332658201706 no 3245 0.0311323386215914 4670 16643986
SGTC_297 0986-0032 24 µM -1.86557758996635 0.0293524365031847 no 3246 0.0310502436927202 4629 2847425
SGTC_1548 st061468 90.8 µM -1.87309850884902 0.0288378336436053 no 3247 0.0305273916224752 4696 390799
SGTC_473 2-arachidonoylglycerol 10 µM -1.88310870106226 0.0281645628546284 no 3248 0.029842819148888 4524 5282280 An endocannabinoid.
SGTC_1460 k062-0059 9.15 µM -1.8834306693597 0.0281431268224422 no 3249 0.0298210136493641 4534 1373085
SGTC_2723 salbutamol 83.58 µM -1.88390517577047 0.0281115598568777 no 3250 0.0297889015078801 4655 9884233 β2-adrenoceptor agonist
SGTC_2854 9024559 71.43 µM -1.89227670224069 0.0275594673904439 no 3251 0.0292270616941334 4626 3163529
SGTC_906 1165-0455 526 µM -1.89241861769876 0.0275501867068898 no 3252 0.0292176136934569 4624 3252859
SGTC_1264 0783-0040 158 µM -1.89431619475978 0.0274263431457898 no 3253 0.0290915263451337 4577 2855798
SGTC_2618 avocadyne 43.43 µM -1.8956889596067 0.0273370406296841 no 3254 0.0290005930326481 4609 3015189
SGTC_1681 tripelennamine 100 µM -1.9000556860512 0.0270545830507696 no 3255 0.0287129061236725 4590 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1926 methyl fluorone black 53.6 µM -1.903749122605 0.0268175817089604 no 3256 0.0284714327542086 4318 72721 Reacts with homocysteine.
SGTC_2810 7959871 45.46 µM -1.90557484588203 0.0267010700141698 no 3257 0.028352694123334 4595 2974535
SGTC_2622 2-methoxyxanthone 59.94 µM -1.92015893719573 0.0257854549514895 no 3258 0.0274189133085406 4640 71034 A hepatoprotective.
SGTC_2957 9076800 11.52 µM -1.93216355651759 0.0250516364527437 no 3259 0.0266696608680411 4640 16459615
SGTC_877 0771-0151 33.1 µM -1.93241109823526 0.0250366908732858 no 3260 0.0266543926496283 4670 6166523
SGTC_2478 5763493 32.33 µM -1.94224159832838 0.0244491788713916 no 3261 0.0260539296948067 4631 1365576 YLR208W SEC13
SGTC_1416 3966-0321 25.3 µM -1.9425996541923 0.0244280002553274 no 3262 0.02603227436606 4718 582530 YLR208W SEC13
SGTC_1632 st005650 90 µM -1.94602998639658 0.0242258792689703 no 3263 0.0258255688489286 4669 2759605
SGTC_1957 st077035 62.4 µM -1.94967287105024 0.0240127740135798 no 3264 0.0256075608942143 4686 705593
SGTC_2179 6298986 200 µM -1.95315812968978 0.0238103663318906 no 3265 0.0254004303597116 4635 738374
SGTC_2653 dihydrofissinolide 100 µM -1.96908009278081 0.0229038448675837 no 3266 0.0244719472355204 4741 6857746
SGTC_536 3852-0578 10.6 µM -1.98330052637202 0.0221189516203572 no 3267 0.0236669353266062 4675 2869208
SGTC_3343 9148379 18.9835 µM -1.98656998119836 0.021941740251171 no 3268 0.0234850352829396 4696 1955036
SGTC_100 0086-0128 49.5915 µM -1.99166557490912 0.0216679391421556 no 3269 0.0232038816194693 4664 93297
SGTC_3335 9143315 29.6265 µM -1.99998728398944 0.0212269977439429 no 3270 0.02275081850661 4683 4899691
SGTC_1733 st037357 54.9 µM -2.00045845229788 0.0212022606854161 no 3271 0.0227253910106563 4622 1272339 YGL099W LSG1
SGTC_2404 5161160 200 µM -2.00925452812784 0.020744911063356 no 3272 0.0222550737920587 4654 2831543
SGTC_792 4534-1957 155 µM -2.00983798540588 0.0207148720765437 no 3273 0.0222241695127531 4653 1717904
SGTC_2181 6316240 54.2555 µM -2.02003130928918 0.02019598842088 no 3274 0.0216900700072745 4699 12779990
SGTC_502 l-744,832 89.3 µM -2.02824010164123 0.0197861764328489 no 3275 0.0212678744627851 4692 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_574 1315-0397 40 µM -2.03879231382615 0.0192697599236572 no 3276 0.0207353798761126 4681 6794277
SGTC_425 3825-7017 13.1 µM -2.03966030874372 0.0192277955704918 no 3277 0.0206920853828326 4672 3397440
SGTC_1107 amlodipine 47 µM -2.04484997127503 0.018978511814916 no 3278 0.0204348257169827 4274 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2428 5615643 7.78 µM -2.04743533184743 0.0188553540925255 no 3279 0.0203076801352666 4693 2253075
SGTC_2211 7117706 200 µM -2.05034976914349 0.0187173362008212 no 3280 0.0201651555804112 4688 822771
SGTC_218 alverine citrate 93.75 µM -2.05274550024902 0.0186045272529746 no 3281 0.0200486333455468 4726 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1442 4112-3290 3 µM -2.06154101628355 0.0181953187663192 no 3282 0.0196257273080779 4725 704353
SGTC_419 nsc-638432 893 µM -2.08104899277657 0.0173150160422995 no 3283 0.0187147109513359 4691 368090
SGTC_2155 5570423 76 µM -2.09269741468585 0.0168069250809358 no 3284 0.0181880870986409 4706 797402
SGTC_880 0833-0487 87.2 µM -2.09972418727809 0.0165066343824169 no 3285 0.0178765553119144 4700 76075
SGTC_999 SEC7.066 22.7 µM -2.0999470399527 0.0164971863489045 no 3286 0.0178667500656757 4697 740511 YDR170C SEC7
SGTC_94 0334-0113 514.748 µM -2.10105144004107 0.0164504326312538 no 3287 0.017818225476069 4706 6795178
SGTC_34 0469-0683 81.75 µM -2.10315551489098 0.0163616725248887 no 3288 0.0177260887404181 4692 3690923
SGTC_1529 apigenin 74 µM -2.10421020286962 0.0163173351796898 no 3289 0.0176800574640033 4708 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1964 st076914 61 µM -2.10605046614228 0.0162402199333789 no 3290 0.0175999844405322 4734 24208661
SGTC_2690 usnic acid 100 µM -2.11624432328571 0.0158186828747532 no 3291 0.0171620166586281 4692 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1184 1269-1718 139 µM -2.11962859591796 0.0156808268558308 no 3292 0.0170186894785609 4732 5403821
SGTC_2356 9061756 188.97 µM -2.12478781721236 0.0154726532401245 no 3293 0.0168021609193762 4728 20104043
SGTC_3080 9117754 49.47 µM -2.14724351314294 0.0145939793113608 no 3294 0.0158869501095289 4703 9550191
SGTC_787 4152-0075 138 µM -2.16592445656161 0.0138960636200876 no 3295 0.0151584800513487 4718 9566539
SGTC_555 4296-0685 37 µM -2.16680498636815 0.0138638898095161 no 3296 0.0151248635414576 4713 2908540 YHR072W ERG7
SGTC_2183 6420625 130.508 µM -2.17275229807248 0.0136482577169384 no 3297 0.0148994826469597 4744 2897619
SGTC_2731 amoxapine 43.43 µM -2.17319047703369 0.01363248572163 no 3298 0.0148829921118738 4791 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2937 9044753 11.33 µM -2.17680313836215 0.0135030484249558 no 3299 0.0147476294002158 4668 6465530 YGL099W LSG1
SGTC_1082 camptothecin 424.86 nM -2.20624108614865 0.0124873044428281 no 3300 0.0136835619673718 4630 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2328 6201408 200 µM -2.21233021426317 0.0122856642670497 no 3301 0.0134719284464203 4678 2890418
SGTC_2352 9027995 87.8 µM -2.21311268006583 0.0122599587450428 no 3302 0.0134449390602583 4705 2997347
SGTC_464 bw-b 70c 158 µM -2.21441592916004 0.0122172479274556 no 3303 0.0134000900610851 4711 5353454
SGTC_613 3914-0030 117 µM -2.2217736844701 0.0119785264481737 no 3304 0.0131493020003045 4554 1145395
SGTC_3134 9127454 49.47 µM -2.23471492313993 0.0115684557439501 no 3305 0.0127180351312989 4719 24262820
SGTC_2059 5238311 157 µM -2.23716498135961 0.011492208180672 no 3306 0.0126377795909315 4699 703021
SGTC_2655 perillic acid 100 µM -2.24433078161568 0.0112717033554885 no 3307 0.0124055632226057 4755 5702197 An apoptosis inducer.
SGTC_485 niflumic acid 177 µM -2.24931379295355 0.011120543185569 no 3308 0.0122462694484987 4752 4488 A COX2 inhibitor.
SGTC_1699 st031318 29.054 µM -2.25058555086426 0.0110822478050028 no 3309 0.0122058997130568 4759 5340658
SGTC_1182 1222-0449 220 µM -2.26317694508879 0.0107092413829323 no 3310 0.0118123919146101 4736 658318
SGTC_370 0180-0345 38.7 µM -2.27330640682904 0.0104171493716274 no 3311 0.0115038608612296 4629 3989527
SGTC_2587 piperic acid 92.2 µM -2.30733262677289 0.00948621385769187 no 3312 0.0105181419914538 4702 5370536
SGTC_511 blebbistatin 171 µM -2.32872881269811 0.00893881987737519 no 3313 0.00993671836105576 4745 3476986 A myosin inhibitor.
SGTC_440 fluspirilene 35.1 µM -2.34451081232277 0.00855298713588418 no 3314 0.00952602905571459 4729 3396 An atypical antipsychotic.
SGTC_1030 k029-0042 36.7 µM -2.3467259363205 0.0085000189204831 no 3315 0.00946958989423339 4730 6080581
SGTC_396 dithiazanine 1.25 µM -2.35016444175029 0.00841836729722889 no 3316 0.00938255940779753 4730 10578 An antihelmenthic.
SGTC_2624 nerol 100 µM -2.35162004517362 0.00838401011090975 no 3317 0.00934592856760491 4680 637566 A natural product oil.
SGTC_1045 1348-1485 165 µM -2.35989181431895 0.00819109603470582 no 3318 0.00914013262142122 4721 6810614
SGTC_860 0443-0016 25.1 µM -2.39820115253387 0.00734761281064594 no 3319 0.00823790733061944 4758 5337942
SGTC_1137 ixabepilone 100 µM -2.43639801687871 0.00658378644269349 no 3320 0.00741717590486588 4717 154225 A novel microtubule stabilizer.
SGTC_1459 k035-0031 35.7 µM -2.47405648187363 0.00590033208412933 no 3321 0.00667942874978626 4642 3877128 YMR208W ERG12
SGTC_220 paclitaxel 373.376 µM -2.47630384204169 0.00586161068842321 no 3322 0.00663752749907833 4748 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_721 1187-1332 279 µM -2.51140405666059 0.00528542595518977 no 3323 0.00601259844623167 4772 25730
SGTC_1753 st043925 64 µM -2.53515492308279 0.00492468052679726 no 3324 0.00561988028652987 4766 670181
SGTC_2694 st077685 81.9 µM -2.57203909627995 0.00440784743594865 no 3325 0.00505507369437182 4711 2838096
SGTC_2580 diallyl disulphide 81.36 µM -2.60124091021089 0.00403362803418459 no 3326 0.00464435994419877 4742 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_680 0417-1641 114 µM -2.60905120719068 0.00393848516518685 no 3327 0.00453968273164232 4788 2835990
SGTC_750 4073-0104 132 µM -2.63304783754449 0.00365861388966639 no 3328 0.00423112137990499 4574 22330957
SGTC_1439 4092-1168 46 µM -2.74523152420082 0.00257283835338476 no 3329 0.00302341106113739 4792 2886240
SGTC_2679 rapamycin 1 nM -2.77216668548541 0.00235994845295557 no 3330 0.00278422572251557 4673 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_92 0063-0024 660.874 µM -2.78363812505206 0.00227422460042065 no 3331 0.00268764848108871 4795 3594437
SGTC_82 0054-0107 293.755 µM -2.79552956175883 0.00218834878785548 no 3332 0.00259073814024939 4784 3104697
SGTC_3302 9125395 16.351 µM -2.80941829927339 0.00209177743277138 no 3333 0.00248155572399902 4759 17599668
SGTC_678 1218-2179 85.9 µM -2.81602099008301 0.00204723752522456 no 3334 0.0024311244920482 4800 6820081 YOR116C RPO31
SGTC_209 4077-0173 175.592 µM -2.8540408621241 0.00180709831754613 no 3335 0.00215834893206754 4757 15993494
SGTC_719 2810-4230 27.3 µM -2.89869897453286 0.00155791567036832 no 3336 0.00187357232255884 4798 721079
SGTC_2355 9061122 103.12 µM -2.96828210872152 0.00123150575031901 no 3337 0.00149734669477454 4783 5302957
SGTC_1431 4049-0260 9.09 µM -3.01905953132983 0.00103421634582644 no 3338 0.00126780350892002 4805 3854841
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -3.05766000091262 0.00090412243172244 yes 3339 0.00111536258962983 4770 5377381
SGTC_2180 6301957 200 µM -3.06805634777847 0.000871751557145778 yes 3340 0.00107727993676614 4793 845462
SGTC_677 0929-0063 136 µM -3.16823579474477 0.000610126331443 yes 3341 0.000766835382900076 4805 1539583
SGTC_2353 9059630 146.67 µM -3.2035325226284 0.000536764236703821 yes 3342 0.000678763531485257 4791 4779114
SGTC_681 1642-0006 26.6 µM -3.24094832305986 0.000467970001908469 yes 3343 0.000595663891446405 4807 4446530
SGTC_3028 9087778 49.47 µM -3.32869471222615 0.000337399601267628 yes 3344 0.000436269949508623 4795 17217395
SGTC_367 0335-0881 7.1 µM -3.40055173119359 0.000256629194891013 yes 3345 0.000336250049224288 4782 23828853
SGTC_1127 asiatic acid 681.4 nM -3.4414247139012 0.000219132358989722 yes 3346 0.000289329737615535 4791 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1720 st037298 9.481 µM -3.49941694805553 0.000174632377983271 yes 3347 0.000233138417871422 4791 597396
SGTC_688 0527-0193 473 µM -3.50838534103394 0.000168557561972888 yes 3348 0.000225417761142376 4801 4007154
SGTC_2635 hydroquinidine 100 µM -3.53064993112661 0.000154320354259124 yes 3349 0.000207269998979979 4784 442912 An experimental heart treatment.
SGTC_1131 3454-3128 32.3 µM -3.53639087748086 0.000150836326150016 yes 3350 0.000202817019751316 4788 710982
SGTC_1947 st076332 61.6 µM -3.54694283691201 0.000144623968266826 yes 3351 0.000194864571752987 4790 24208416
SGTC_573 3702-0553 84.7 µM -3.62346870050081 0.000106246648246703 yes 3352 0.000145339196639575 4806 1222756
SGTC_361 000s-0510 1.45 µM -4.11143772453789 1.29376342658459e-05 yes 3353 1.96601468693868e-05 4797 660
SGTC_2897 9048598 12.99 µM -4.36547560801271 3.92803037240057e-06 yes 3354 6.34232285299527e-06 4808 6467404
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -4.5131262591977 1.90604549994402e-06 yes 3355 3.19394838570771e-06 4805 115019
SGTC_636 0kpi-0074 126 µM -4.66837628550103 8.69895601833234e-07 yes 3356 1.51794748863513e-06 4810 616434