SGTCid condition conc unit SCJ1|YMR214W.score SCJ1|YMR214W.strain.pval SCJ1|YMR214W.strain.significant SCJ1|YMR214W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_453 enantio-paf c16 10 µM 16.1530047240505 5.65511190354676e-52 yes 1 5.40810367785445e-59 1 13871343 A lipid and platelet activating factor
SGTC_2582 agaric acid 100 µM 13.0425920740639 1.34021600328025e-34 yes 2 3.50174419231306e-39 28 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_568 1193-0097 7.48 µM 8.16396690240391 1.04254622391093e-14 yes 3 1.62098884362087e-16 33 3646150
SGTC_2896 9052656 71.43 µM 8.155903776713 1.10550078510863e-14 yes 4 1.7328915188283e-16 16 6469436
SGTC_58 0957-0393 9 µM 7.12350695311815 1.26760537490328e-11 yes 5 5.26074705753217e-13 160 6997992
SGTC_8 0354-0001 70 µM 6.76331422129953 1.19329711040286e-10 yes 6 6.74351425654137e-12 20 4993152
SGTC_59 0330-0160 1.33 µM 6.48177459409977 6.37156533085517e-10 yes 7 4.53250006500805e-11 29 4293482
SGTC_2586 curcumin 80 µM 6.27451378635314 2.09402188440652e-09 yes 8 1.75364277943077e-10 12 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_124 0136-0217 7.121 µM 6.18263291717353 3.50714880209741e-09 yes 9 3.1520595625334e-10 23 3976905
SGTC_178 4092-0806 87.505 µM 5.89245539515819 1.70513100576054e-08 yes 10 1.90249412091967e-09 42 2169044
SGTC_2396 5342950 42.78 µM 5.83216456475288 2.34717208329909e-08 yes 11 2.7356458648719e-09 15 1886677
SGTC_116 0155-0182 31.788 µM 5.58356122238804 8.48454049626036e-08 yes 12 1.17821386212235e-08 31 771486
SGTC_1425 4048-4433 7.33 µM 5.56975436871004 9.09816996113066e-08 yes 13 1.27549355864925e-08 13 23734946
SGTC_1658 st012944 20 µM 5.18102307144528 6.08053533096101e-07 yes 14 1.10336096348905e-07 43 24207260
SGTC_1750 st081859 2.357 µM 5.17011547063028 6.4015998449034e-07 yes 15 1.16974696242502e-07 133 5291695
SGTC_268 camptothecin 39.6153 µM 5.07750651189492 9.86866544173389e-07 yes 16 1.912102020744e-07 46 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3200 9114385 49.47 µM 5.05127032448329 1.11413564315086e-06 yes 17 2.19440716227209e-07 13 17018030 YLR208W SEC13
SGTC_3334 9142812 21.919 µM 4.99956288152401 1.4126094786835e-06 yes 18 2.87302155122907e-07 13 45283678
SGTC_3142 9086498 49.47 µM 4.9021616598936 2.19552824309851e-06 yes 19 4.73938900655804e-07 20 25236367
SGTC_207 4185-0010 4.486 µM 4.88805477207896 2.33877686142613e-06 yes 20 5.09186004523996e-07 56 3761753
SGTC_1912 st060209 90.8 µM 4.77876221043211 3.7947787948122e-06 yes 21 8.8188818950413e-07 18 688787
SGTC_3225 9130819 49.47 µM 4.73368797825907 4.61958888623419e-06 yes 22 1.10238289394387e-06 14 4547121
SGTC_2737 bleomycin 30.5 nM 4.71493097888297 5.01105941223897e-06 yes 23 1.20896349138999e-06 68 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_103 0844-0104 51.839 µM 4.48984010077742 1.29969367516979e-05 yes 24 3.56383293100808e-06 119 5375804
SGTC_455 paf C-16 10 µM 4.43595540517718 1.62251405658043e-05 yes 25 4.58324121421478e-06 21 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1737 st035557 69.7 µM 4.39033761343433 1.95401888890079e-05 yes 26 5.65874029363711e-06 11 5716916
SGTC_2585 alliin 100 µM 4.34195362455327 2.37540864011585e-05 yes 27 7.06106730305272e-06 18 87310 A garlic compound which reacts with lipids.
SGTC_1903 st060211 78.3 µM 4.24269740128233 3.52418158328543e-05 yes 28 1.10424566047656e-05 19 688960
SGTC_3318 9139014 38.6185 µM 4.23616357997813 3.61585084130521e-05 yes 29 1.1368558122558e-05 8 16643984
SGTC_3324 9138759 60.749 µM 4.14477153173298 5.15918478561985e-05 yes 30 1.70076339368375e-05 16 45595710
SGTC_1614 st002383 48.6 µM 4.13838316150487 5.28759990591607e-05 yes 31 1.74880954934395e-05 13 1947235
SGTC_119 0121-0043 24.815 µM 4.10413394875012 6.0290765646517e-05 yes 32 2.02916143931538e-05 96 1092378
SGTC_2249 haloperidol 116.36 µM 4.09611446024263 6.21633302889166e-05 yes 33 2.10071130982622e-05 101 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_839 0122-0028 230 µM 4.0315721961051 7.93588771653938e-05 yes 34 2.77024855657219e-05 37 759448
SGTC_1493 4348-0038 111 µM 3.80010847403621 0.00018518133196443 yes 35 7.23163817898178e-05 36 800424
SGTC_3133 9127736 49.47 µM 3.77991367856238 0.000198971091971736 yes 36 7.84413696177797e-05 24 27243420
SGTC_673 1082-0474 110 µM 3.75891206405112 0.000214325360706 yes 37 8.5326899496392e-05 69 3098046
SGTC_1281 0884-0031 11.8 µM 3.73984498463269 0.000229216679716388 yes 38 9.20668874195101e-05 26 1548255
SGTC_318 1488-0629 67.2 µM 3.7301270151224 0.000237172601914594 yes 39 9.5691633329475e-05 30 3662576
SGTC_273 hydroxyurea 18.1 mM 3.65160728414672 0.00031156721327809 yes 40 0.000130302094468754 42 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2127 5253358 187.912 µM 3.56141438734271 0.000423573891568005 yes 41 0.000184431193384772 35 20612
SGTC_2488 5268135 45.7 µM 3.52898262913427 0.000472256992405525 yes 42 0.000208580256022888 69 1270356 YLR208W SEC13
SGTC_1340 1486-1359 257 µM 3.49802543184235 0.000523514862644455 yes 43 0.00023435821752113 39 4309068
SGTC_236 1509-0011 5.31 µM 3.42272137843014 0.000670438661693466 yes 44 0.000309987951944316 426 3107280
SGTC_1308 1187-1617 41.4 µM 3.40850221777623 0.00070213013751987 yes 45 0.000326602771144202 65 2882570
SGTC_3016 9080866 49.47 µM 3.3493436920197 0.000849373573397967 yes 46 0.000405016231694494 44 17066299
SGTC_1913 st060213 96.1 µM 3.32990310897508 0.000903644778939021 yes 47 0.000434381046538626 61 688959
SGTC_2428 5615643 7.78 µM 3.23671885775175 0.00121079433533315 no 48 0.000604562348405725 52 2253075
SGTC_2927 9011802 47.9 µM 3.22142777569752 0.00126948766083235 no 49 0.000637768034440605 53 43912568
SGTC_2505 galangin 7.89 µM 3.18158855875702 0.00143483438482134 no 50 0.000732348676064917 30 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3190 9110366 49.47 µM 3.18092582671022 0.00143774404142236 no 51 0.000734026057195656 34 17123768
SGTC_709 3807-1509 243 µM 3.17460153193756 0.00146578237983561 no 52 0.00075021194010983 36 1886677 YPL242C IQG1
SGTC_2363 9053361 176 µM 3.12059817153251 0.00172631029595723 no 53 0.000902420637454903 66 6469797 YMR079W SEC14
SGTC_2250 alverine citrate 130 µM 3.11281050300614 0.00176717583117555 no 54 0.000926574814482467 245 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1093 fluphenazine 7.97 µM 3.04240063859062 0.00217859395048827 no 55 0.0011734964365797 52 6602611 An atypical antipsychotic.
SGTC_737 1950-0117 57.9 µM 3.04232695355594 0.00217906659801893 no 56 0.00117378376553213 55 5393513
SGTC_192 3455-0609 60.9 µM 3.03125897818438 0.00225112605951013 no 57 0.00121768132783612 52 3769639
SGTC_121 0557-0495 61.343 µM 3.02122509928273 0.0023183114105624 no 58 0.00125877062948145 134 3104427
SGTC_1615 st002656 86.5 µM 2.96705956105294 0.00271335882883254 no 59 0.00150331354432223 52 1584458
SGTC_660 4031-1742 102 µM 2.96679308429298 0.00271544413621239 no 60 0.00150461700478583 100 6738706
SGTC_2688 kanamycin b 96.69 µM 2.96256410444729 0.00274873215782876 no 61 0.00152544137110992 544 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_386 1509-0011 3.07 µM 2.95832657284479 0.00278245648536011 no 62 0.0015465711883835 203 3107280
SGTC_334 1502-1024 68.5 µM 2.93424907949263 0.00298126286257097 no 63 0.0016717788687049 52 3296216
SGTC_1133 3473-0247 50 µM 2.9331958542152 0.00299024446680987 no 64 0.00167746090965302 111 711311
SGTC_2376 9072922 81.32 µM 2.87000355661899 0.0035758548101268 no 65 0.00205233591019464 90 17087968
SGTC_1817 st052116 64.4 µM 2.86204085625084 0.00365652178553346 no 66 0.00210461321555094 49 4361398
SGTC_2666 tannic acid 100 µM 2.86113757556804 0.00366577491779196 no 67 0.00211061915344988 93 16134267 A thiamine antagonist.
SGTC_500 h-89 112 µM 2.85436844165648 0.00373578864356335 no 68 0.00215612439179799 83 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2555 cholic acid 100 µM 2.85349226669851 0.00374493811076667 no 69 0.00216207901696629 56 6708657 Influences liver metabolism.
SGTC_3231 9132313 49.47 µM 2.84001953695098 0.00388817977377429 no 70 0.00225553854754531 48 4905967
SGTC_1183 1254-0324 198 µM 2.83329795953891 0.00396146285886856 no 71 0.00230352105156202 69 5799357
SGTC_2354 9060492 162 µM 2.82138806134751 0.00409435564007583 no 72 0.00239081609336941 78 6471895
SGTC_288 1315-0019 35.1 µM 2.80749047178451 0.00425446104986836 no 73 0.00249645784437578 86 6811474
SGTC_1797 st048695 56.8 µM 2.80150349407333 0.00432514188481938 no 74 0.00254325451520791 130 592262 YIL048W NEO1
SGTC_2475 5812728 15.03 µM 2.78011799750127 0.00458626229462848 no 75 0.0027169574822623 83 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 2.77680721508116 0.00462792157313296 no 76 0.00274478644016527 100 91467 include heat shock
SGTC_308 4092-1169 104 µM 2.77016361502124 0.00471253744603437 no 77 0.00280140701168682 120 2268590 YDL196W YDL196W
SGTC_893 0958-0369 48.9 µM 2.76615899368533 0.00476420619734823 no 78 0.00283604363926284 85 6819948
SGTC_2149 5554786 194.827 µM 2.75545950564561 0.00490474048576105 no 79 0.00293048795122859 115 745063 YPR165W RHO1
SGTC_1597 7-benzyloxygramine 47.5 µM 2.74660619687219 0.00502380633189289 no 80 0.0030107694011021 266 260807
SGTC_1285 0929-0069 65.5 µM 2.74126665488499 0.0050968545897567 no 81 0.00306014077727449 91 1206237
SGTC_194 1486-1323 56.904 µM 2.73403531883317 0.00519729078944139 no 82 0.00312816665895123 70 5178754
SGTC_2112 5488546 200 µM 2.72437479356017 0.00533421249822525 no 83 0.0032211676104872 82 600757
SGTC_557 1315-0110 16.2 µM 2.72338435525063 0.0053484300007049 no 84 0.00323084168274168 95 6833801
SGTC_2312 7706453 155.7 µM 2.69447850920584 0.0057784859814939 no 85 0.00352494363947955 96 976098
SGTC_134 0269-0018 6.916 µM 2.68828786887087 0.00587448348917142 no 86 0.00359097260442422 229 4378915
SGTC_1559 coumarin 343 70.1 µM 2.68579394111212 0.00591355451915737 no 87 0.00361788488813842 70 108770 A hepatotoxic, DNA x-linker.
SGTC_575 k072-0246 11.9 µM 2.64833439500251 0.00652876899323645 no 88 0.00404447347836878 103 6796779
SGTC_722 3534-0461 190 µM 2.64823671151737 0.0065304446483035 no 89 0.00404564240485171 129 658262
SGTC_2092 5303694 80.6725 µM 2.63590576404284 0.00674504759864166 no 90 0.00419565159793757 121 1963699
SGTC_2918 7977171 22.06 µM 2.63127392923788 0.00682725412807526 no 91 0.00425327203918127 90 2236483
SGTC_1935 st074532 41.6 µM 2.62584460314026 0.00692474032373597 no 92 0.00432171338512277 127 2829742
SGTC_208 k072-0098 12.366 µM 2.61919385000143 0.00704583130163306 no 93 0.00440689231775051 151 5948901
SGTC_1336 1486-0901 104 µM 2.61493134435217 0.00712441832469948 no 94 0.00446226963217043 89 5006114
SGTC_2496 diffractaic acid 79.83 µM 2.60905298533562 0.00723406478053371 no 95 0.00453965914192346 115 94870 An apoptosis inducer which activates caspases.
SGTC_1980 st071811 45.7 µM 2.60893319417295 0.00723631457947819 no 96 0.00454124859330668 87 4974850
SGTC_3281 9140613 49.47 µM 2.60212652383907 0.00736516857775286 no 97 0.0046323832412301 92 16013766
SGTC_1942 st076330 65.2 µM 2.60082778738234 0.00738998282662199 no 98 0.00464995630550834 109 24208414
SGTC_834 0312-0008 75.7 µM 2.56476703622117 0.00810904287197664 no 99 0.00516225496704345 143 6385573 YIL048W NEO1
SGTC_2346 9031566 143.75 µM 2.56214438547832 0.00816366080589462 no 100 0.00520140304363293 91 4771086
SGTC_1530 rhein 70.4 µM 2.5619675611514 0.0081673548594781 no 101 0.0052040519657403 106 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_3082 9117008 49.47 µM 2.54170890105277 0.00860042473116637 no 102 0.00551560020285331 96 41448529
SGTC_658 3253-0951 102 µM 2.53206390139819 0.00881359266896738 no 103 0.00566966620860338 179 1184878
SGTC_411 enrofloxacin 100 µM 2.53137509875009 0.00882899183988764 no 104 0.00568081370080357 76 71188 A bacterial gyrase inhibitor.
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 2.5104110459168 0.00930909200210743 no 105 0.00602953500968259 313 16725076
SGTC_2345 9052315 157.45 µM 2.50417251885954 0.0094563028204838 no 106 0.00613690850678833 125 6469265
SGTC_2983 9022671 12.99 µM 2.48133797459501 0.010012632773075 no 107 0.00654451007248672 100 6405161
SGTC_43 0570-0105 72.5 µM 2.46534407009567 0.0104191183863578 no 108 0.00684408694767847 272 1114046 YDL195W SEC31
SGTC_830 4076-0286 57.8 µM 2.46419202061543 0.010448945432381 no 109 0.00686612606160866 243 6866659
SGTC_332 4112-0506 40.9 µM 2.46273262502964 0.0104868366237422 no 110 0.00689413479183228 106 2790355
SGTC_2544 sphondin 68.51 µM 2.46090604014436 0.0105344300542551 no 111 0.00692933275711919 119 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1170 0310-0127 64.8 µM 2.45693694261399 0.0106384979309964 no 112 0.00700636402026556 132 774975
SGTC_2213 7173844 200 µM 2.45422104210653 0.010710222518281 no 113 0.00705950815655017 110 892728
SGTC_184 1494-0393 24.714 µM 2.44077170126974 0.0110716471682542 no 114 0.007327958299023 183 3090647
SGTC_129 0088-0017 176.636 µM 2.43744108066177 0.0111627731319063 no 115 0.00739581225542055 181 182446
SGTC_2435 5706476 10.6 µM 2.43471896735305 0.0112377339148367 no 116 0.00745167981364739 136 5725375
SGTC_857 0438-0306 1.35 µM 2.43046944835294 0.0113556307251453 no 117 0.0075396386517243 94 4686136
SGTC_973 1325-0077 65.9 µM 2.42737814251347 0.011442068502028 no 118 0.00760419748152888 104 2835149
SGTC_18 0111-0177 500 nM 2.42307446751201 0.011563357518256 no 119 0.00769488579558427 209 721752
SGTC_771 0250-0039 27.3 µM 2.40757678473675 0.0120094190417423 no 120 0.00802939242317774 108 3005115
SGTC_1129 3453-1384 223 µM 2.40501336684179 0.0120846208986361 no 121 0.00808593712707269 169 1084452
SGTC_1834 st055981 52.8 µM 2.3988146152097 0.0122681602537601 no 122 0.00822411985066027 144 471719 YDL150W RPC53
SGTC_3065 9113888 49.47 µM 2.39237999341794 0.0124612336262648 no 123 0.00836975066708969 127 16648368
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 2.39014680262309 0.0125288537222316 no 124 0.00842081972632111 154 5379071
SGTC_871 0574-0004 149 µM 2.37689730858751 0.0129366122865006 no 125 0.00872947395732002 183 9551173
SGTC_1457 k015-0032 57.3 µM 2.37631395864539 0.0129548258580273 no 126 0.00874328849667345 166 4302660
SGTC_2366 9070441 60.58 µM 2.37371549863762 0.0130362255542329 no 127 0.00880505675020451 157 6837235
SGTC_46 0329-0187a 2.197 µM 2.37155878695378 0.0131041223924641 no 128 0.00885661430901809 222 46494817
SGTC_1601 4'-hydroxyflavanone 55.5 µM 2.35999393052648 0.013473440127001 no 129 0.00913761703048026 168 165506
SGTC_352 k048-0007 5.11 µM 2.35668093950874 0.0135808808026374 no 130 0.00921954107366822 206 6811911
SGTC_544 k015-0020 52.4 µM 2.35015978494385 0.0137945241957759 no 131 0.00938267679943406 140 3008304
SGTC_1161 k007-0610 110 µM 2.34695202519917 0.0139006749547152 no 132 0.00946384585267961 277 5843850
SGTC_750 4073-0104 132 µM 2.34384825779441 0.0140040541067883 no 133 0.00954296732580421 104 22330957
SGTC_2183 6420625 130.508 µM 2.33137467964579 0.0144262303076817 no 134 0.00986680573606899 228 2897619
SGTC_2483 5729050 27.16 µM 2.33044355682649 0.0144581796996669 no 135 0.00989135996650747 184 2865180
SGTC_791 1348-1292 225 µM 2.3286519026887 0.014519827688943 no 136 0.00993875703201766 206 5437054
SGTC_1091 telmisartan 47.6 µM 2.32783147262808 0.0145481328291858 no 137 0.00996052709089258 127 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2664 lyso-paf C-16 73.48 µM 2.32364932664921 0.014693157572442 no 138 0.010072148209018 141 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1886 st057356 49.9 µM 2.32046689610397 0.0148043467640946 no 139 0.0101578168540825 135 24207747
SGTC_1900 st060200 72.8 µM 2.31579520880995 0.0149688787519854 no 140 0.0102847264825441 137 688945
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 2.31196798323187 0.0151048386764484 no 141 0.0103897238766148 147 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2443 5493264 126.67 µM 2.31161560771056 0.0151174097895653 no 142 0.010399437877794 136 5340055
SGTC_1757 st041620 31.8375 µM 2.29446573268087 0.0157401995109357 no 143 0.010881880604164 163 5289815
SGTC_2111 5486399 200 µM 2.2879967910961 0.0159807673543374 no 144 0.0110688539956119 202 689674
SGTC_2923 7992654 58.14 µM 2.28785487509688 0.0159860800818196 no 145 0.0110729869582237 156 2985126
SGTC_2157 5649910 96.377 µM 2.28437416479513 0.0161168577196538 no 146 0.0111747752884015 154 2858091
SGTC_1677 st019204 53.9 µM 2.2834519819635 0.016151659310875 no 147 0.0112018791349174 172 3945625
SGTC_1812 st052057 4.327 µM 2.27949426234966 0.0163017489025059 no 148 0.0113188503279378 154 3645418
SGTC_559 1550-0661 158 µM 2.27551813242524 0.0164537379624394 no 149 0.0114374331017337 130 5830875
SGTC_1866 st057638 64 µM 2.26575284864173 0.0168321768264044 no 150 0.0117332598928355 129 688802
SGTC_126 0417-1624 672.48 µM 2.2652197939064 0.0168530471032745 no 151 0.0117495975302776 205 41912 YDL195W SEC31
SGTC_895 0964-0006 13.7 µM 2.26106381723883 0.01701652297836 no 152 0.0118776527730697 135 6738897
SGTC_1150 3909-7983 10.9 µM 2.25162539223351 0.01739282619811 no 153 0.0121729775138235 174 23965914
SGTC_2021 4019055 173 µM 2.24749240934108 0.0175598292800524 no 154 0.0123042875752897 341 44827708 YER133W GLC7
SGTC_576 1073-0113 22.7 µM 2.21622721446786 0.0188680711609855 no 155 0.0133379724739977 275 5439563
SGTC_2967 9089538 49.85 µM 2.20980712423498 0.0191467333312947 no 156 0.0135592755431863 195 728216
SGTC_2329 6138490 200 µM 2.20461548228723 0.019374626515563 no 157 0.0137405442031694 165 720019
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 2.20333176528371 0.0194313308446408 no 158 0.0137856868281737 137 2724278 An inhibitor of dopamine biosynthesis.
SGTC_3198 9112019 49.47 µM 2.20233235802515 0.0194755741993064 no 159 0.0138209200501275 146 45595555
SGTC_3095 9117207 49.47 µM 2.19621164690337 0.0197484065049425 no 160 0.0140383990624027 106 17015229
SGTC_2212 7123476 200 µM 2.18405768755332 0.0202997984169849 no 161 0.0144790046749625 90 1085715
SGTC_2360 9040895 200 µM 2.17897832856427 0.0205340722332433 no 162 0.0146666390859754 158 4914414
SGTC_130 0136-0219 337.655 µM 2.16985952255918 0.0209604049225446 no 163 0.0150087447695053 175 234244
SGTC_3031 9088762 49.47 µM 2.16948749428601 0.0209779562888239 no 164 0.0150228463907988 178 205253
SGTC_235 0330-0087 5 mM 2.16908266396956 0.0209970693034929 no 165 0.0150382043003636 185 46494818 YHR062C RPP1
SGTC_2890 9046729 58.44 µM 2.1618086294505 0.0213430132676087 no 166 0.0153164650289286 154 903329
SGTC_1997 st073024 93.8 µM 2.16096139349309 0.0213836183544743 no 167 0.0153491608812235 147 686268
SGTC_36 0335-0881 14.2 µM 2.15313062191665 0.0217620212361085 no 168 0.0156542071254184 295 23828853
SGTC_408 cantharidin 100 µM 2.14312200944975 0.0222538837097415 no 169 0.0160516512935708 197 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2198 6589944 200 µM 2.12251760719132 0.0232960396420589 no 170 0.0168971478610399 136 5290268
SGTC_3000 9075062 71.4286 µM 2.12024105405672 0.023413666316627 no 171 0.0169928609333068 184 17057871
SGTC_1573 oleylamine 1.06 µM 2.11802365755241 0.0235287164801007 no 172 0.0170865320840368 220 5356789 An amine of the fatty acid oleic acid.
SGTC_764 1951-2361 146 µM 2.11777396958317 0.0235417013417824 no 173 0.0170971074337995 207 5438930
SGTC_70 0141-0289 43.283 µM 2.11757678058645 0.0235519602878371 no 174 0.0171054631812403 455 352408
SGTC_2523 spermine 47.74 µM 2.11558712734698 0.0236556844604184 no 175 0.0171899688068897 180 1103 A DNA binding polyamine.
SGTC_201 4262-0159 12.803 µM 2.10549492491019 0.0241877431978256 no 176 0.0176241243151055 161 1341029
SGTC_537 1334-0398 209 µM 2.10363141145553 0.0242870785067718 no 177 0.0177053058515433 204 5846986
SGTC_3308 9128332 17.569 µM 2.10358517964791 0.0242895472596688 no 178 0.0177073239295456 299 17332805 YDL196W YDL196W
SGTC_502 l-744,832 89.3 µM 2.09846847753142 0.0245640815760689 no 179 0.0179318908426577 197 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_905 2-aminofluorene 215 µM 2.09233187323705 0.0248967679801524 no 180 0.0182044191969652 215 1539 An established DNA mutagen. YPR165W RHO1
SGTC_903 1134-0042 114 µM 2.06592157231914 0.0263719867408497 no 181 0.0194179427864408 210 701009
SGTC_1687 st020778 55.3625 µM 2.06090609073581 0.0266602379418331 no 182 0.0196560000589565 398 4259299
SGTC_1444 4112-3581 28 µM 2.05849468999716 0.0267997607013181 no 183 0.0197713352369398 193 2877249
SGTC_50 0929-0078 56.389 µM 2.05643480712041 0.0269194271394892 no 184 0.0198703120733244 228 1377751
SGTC_914 3820-6779 408 µM 2.05420135704023 0.0270496804441902 no 185 0.01997810356385 207 2893481
SGTC_528 3492-0019 172 µM 2.0497953507627 0.0273081782702709 no 186 0.0201922027498765 472 2869262
SGTC_1259 0671-0132 43 µM 2.04755728982043 0.0274402711310504 no 187 0.0203016989581006 218 X1259
SGTC_1625 st003711 30.1 µM 2.04548172374937 0.0275632491062605 no 188 0.0204036946110308 211 24207034 YER133W GLC7
SGTC_2115 tiliquinol 12.7705 µM 2.04539602191814 0.0275683368291776 no 189 0.0204079154147716 160 71208 A bioactive hydroxyquinoline.
SGTC_1413 3910-0535 34.4 µM 2.04414805413536 0.0276425116683555 no 190 0.0204694615501906 191 2876951
SGTC_391 gliotoxin 8.33 µM 2.04165038581955 0.0277914639752363 no 191 0.0205931117465693 251 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_450 aminopyrene 156 nM 2.03979411895054 0.0279025980063707 no 192 0.0206854179137193 243 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1506 4226-2149 212 µM 2.0388019954145 0.0279621477311243 no 193 0.0207348965479733 254 991114
SGTC_2506 ethyl hematommate 54.16 µM 2.03523944681816 0.0281768539132758 no 194 0.0209133928508321 177 3940691 An allergen.
SGTC_939 1165-0479 45.3 µM 2.02869825651256 0.0285746490997221 no 195 0.0212445167985563 247 1377347
SGTC_3144 9087057 49.47 µM 2.02299077462012 0.0289255490094245 no 196 0.0215370493317578 202 17249618
SGTC_797 k781-0471 270 µM 2.01222382491631 0.0295972604480368 no 197 0.0220981740526426 216 23738129
SGTC_1804 st050076 49.1 µM 2.00620358586244 0.0299784512604869 no 198 0.0224172657274926 212 3895976
SGTC_1334 1486-0610 236 µM 2.00290128727404 0.0301892703070881 no 199 0.0225939424523951 215 3742339
SGTC_1694 st024011 44.9 µM 2.00100041625236 0.0303111783798749 no 200 0.0226961725166978 231 2787533
SGTC_1304 1165-0502 251 µM 2.00069050918594 0.0303310921946477 no 201 0.0227128764240084 273 767425
SGTC_2536 dehydroabietamide 32.04 µM 1.98928883825012 0.0310713045029298 no 202 0.0233346654855096 253 3983547
SGTC_15 0266-0086 27.098 µM 1.98577196702866 0.0313026183080937 no 203 0.023529324902561 310 1712902 YIL048W NEO1
SGTC_2380 9035439 200 µM 1.98413934775647 0.0314104829404477 no 204 0.0236201538675085 247 6462575
SGTC_1770 st043884 66.3 µM 1.96385027273563 0.0327767726385918 no 205 0.0247737290310481 211 670149
SGTC_649 1123-0311 367 µM 1.95657040355361 0.0332787991538941 no 206 0.0251989987625698 303 693629 YIL048W NEO1
SGTC_2036 5160441 105 µM 1.95007137587898 0.0337323124655948 no 207 0.025583806193116 307 134534 YIL048W NEO1
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.94911751947777 0.0337993001888711 no 208 0.0256406959585189 273 676296 Flavone; oxidizing agent.
SGTC_3071 9117417 49.47 µM 1.94730711489089 0.0339267428334066 no 209 0.0257489631167688 164 45595590 YGL055W OLE1
SGTC_1105 epirubicin 18.1 µM 1.94024890620182 0.0344273819912298 no 210 0.0261747237643373 216 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1511 0906-3109 28.5 µM 1.93491135432437 0.0348099924440605 no 211 0.0265005873133823 350 2882180
SGTC_2928 9011484 9.79 µM 1.93462975224284 0.0348302750268505 no 212 0.0265178731581482 233 2994751
SGTC_911 3456-4043 236 µM 1.92811999137681 0.0353018559838216 no 213 0.0269201014594084 279 914281
SGTC_2920 7982904 15.77 µM 1.9228697511238 0.0356859985983966 no 214 0.0272482047417201 232 6456808
SGTC_2466 5983409 37.09 µM 1.91704174574231 0.0361164196221591 no 215 0.0276163141949354 228 2879657
SGTC_2407 paclitaxel 400 µM 1.91683133040407 0.0361320387863502 no 216 0.0276296816363456 287 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_723 4182-0001 115 µM 1.90918529335372 0.0367033681225034 no 217 0.0281190963937449 233 744821 YLR208W SEC13
SGTC_2810 7959871 45.46 µM 1.90419833750464 0.0370799707134954 no 218 0.0284421790882397 317 2974535
SGTC_1719 st032227 49.2 µM 1.90311887706018 0.037161903301883 no 219 0.0285125176482137 247 3125804
SGTC_1338 1486-1223 76 µM 1.90255667661538 0.037204633672204 no 220 0.0285492083787229 249 3444526
SGTC_2710 st078562 53.7235 µM 1.9012834398501 0.0373015551975656 no 221 0.0286324484835533 224 17250908
SGTC_1707 st032323 6.317 µM 1.90073849602373 0.0373431004823732 no 222 0.0286681367822518 311 3132057 YMR211W DML1
SGTC_969 1313-0238 134 µM 1.90027676582022 0.0373783313231611 no 223 0.0286984043754219 303 5212874
SGTC_1941 st076221 61.8 µM 1.89896141434233 0.0374788438526287 no 224 0.0287847747304302 337 2828568
SGTC_2914 7968218 45.32 µM 1.89761973795353 0.0375815952900107 no 225 0.0288730962028487 181 2977111
SGTC_724 3910-0327 137 µM 1.89746433482089 0.0375935115899463 no 226 0.0288833408073385 254 2885483
SGTC_2508 celastrol 40.54 µM 1.89587720181339 0.0377153895520686 no 227 0.0289881421166649 203 122724 Celastrol is a natural product and antioxidant.
SGTC_3319 9138450 16.7555 µM 1.88932166207363 0.0382222195745929 no 228 0.0294243703241743 226 2029690
SGTC_2946 9065502 71.43 µM 1.8885560413622 0.0382817727167168 no 229 0.0294756709745034 138 16489101
SGTC_1899 st063254 59.6 µM 1.88473459658973 0.0385801526863147 no 230 0.0297328394938024 219 3093813
SGTC_1386 3228-0095 33.8 µM 1.88064962212479 0.0389012020524084 no 231 0.0300097984168681 236 870181
SGTC_2473 5854593 8.94 µM 1.88062276050909 0.0389033203591079 no 232 0.0300116266748057 209 2872951
SGTC_1268 0828-0275 2.46 µM 1.87813771011757 0.0390996981062609 no 233 0.0301811643713332 254 745337
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.87318904566089 0.0394931630907348 no 234 0.0305211422303969 264 2333 A French combination drug.
SGTC_1926 methyl fluorone black 53.6 µM 1.87234214511364 0.0395608212524687 no 235 0.0305796417957411 279 72721 Reacts with homocysteine.
SGTC_2939 9044578 71.43 µM 1.86635894476501 0.0400415039134121 no 236 0.0309955815119418 279 2653634
SGTC_751 0833-0568 350 µM 1.86601572691074 0.0400692208985215 no 237 0.0310195826028049 250 6954252
SGTC_166 k072-0058 166.424 µM 1.86557120944013 0.0401051416275681 no 238 0.0310506903910094 278 5846229
SGTC_1945 st075991 56.6 µM 1.85780993378537 0.040736544518491 no 239 0.0315980049787671 249 1084980
SGTC_546 peri-Naphthalide 147 µM 1.85734406621955 0.0407746994200811 no 240 0.0316311093963012 256 223824 A penicillin ester.
SGTC_2239 6685329 187.64 µM 1.85279375109285 0.041148900441618 no 241 0.0319559631242506 287 805680
SGTC_426 0988-0037 14.6 µM 1.84808647247717 0.0415389348751795 no 242 0.0322949172014411 315 5383008
SGTC_2364 9055074 200 µM 1.84376341628553 0.0418997670066526 no 243 0.0326088132181862 257 6470630
SGTC_1748 st037455 53.6035 µM 1.84373478655517 0.0419021650736982 no 244 0.0326109003729754 301 580690
SGTC_373 0844-0104 25.9 µM 1.83579393245599 0.0425716043149353 no 245 0.033194069592516 303 5375804
SGTC_3045 9092950 49.47 µM 1.833951876651 0.042728124792626 no 246 0.0333305689661296 280 44120432
SGTC_3245 9134821 49.47 µM 1.83165102090068 0.0429242828149084 no 247 0.033501715105878 286 17014901
SGTC_1000 4048-0884 8.67 µM 1.82771478997565 0.0432615505455744 no 248 0.0337961836368649 288 13040088
SGTC_1454 4239-0054 42.6 µM 1.82429799489695 0.0435560435993441 no 249 0.0340535166993601 323 1340767
SGTC_2495 cafestol 54.53 µM 1.82129438916249 0.0438162582974795 no 250 0.0342810594460864 277 16667697 An anti-infammatory.
SGTC_478 N-arachidonylglycine 10 µM 1.82016898536559 0.0439140790356366 no 251 0.0343666373254651 139 5283389
SGTC_2311 7694451 200 µM 1.81880637510655 0.0440327535521222 no 252 0.0344704877235528 279 2163142
SGTC_395 anisomycin 6.25 µM 1.81868723373544 0.0440431422754875 no 253 0.034479580245207 210 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_376 3970-0862 59.1 µM 1.81567089256292 0.0443068160450087 no 254 0.034710435822701 281 3135186
SGTC_1779 st039427 55 µM 1.8153740411594 0.0443328339589573 no 255 0.0347332237809656 341 1124498
SGTC_2752 diclazuril 33.15 µM 1.81052893637595 0.0447592323369614 no 256 0.0351069006003195 446 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2881 9058953 51.95 µM 1.80718549559191 0.045055396415883 no 257 0.0353666808400176 313 17122249
SGTC_691 1548-0686 185 µM 1.8037661287501 0.0453599152923036 no 258 0.035633988904394 326 46495133
SGTC_2381 9035592 200 µM 1.80194645382387 0.0455226439060494 no 259 0.0357769152634392 242 4749657
SGTC_1324 1418-0026 34.4 µM 1.80016548044278 0.0456823657731844 no 260 0.0359172563513969 305 1372513
SGTC_3132 9126706 49.47 µM 1.79573688943159 0.0460814854345735 no 261 0.0362681860153677 278 850858
SGTC_600 1495-0418 41.6 µM 1.79520123067067 0.0461299501296763 no 262 0.0363108222401452 273 5377768
SGTC_1841 st054148 70 µM 1.7949795440594 0.0461500196004373 no 263 0.0363284795781074 270 675442
SGTC_1036 k216-0215 33.5 µM 1.78982969729628 0.046618216234005 no 264 0.0367406467352523 356 622330
SGTC_2388 9080168 200 µM 1.78873757508448 0.0467179943814681 no 265 0.036828544262814 231 15943073
SGTC_605 1315-0399 119 µM 1.7866841569945 0.0469060620410858 no 266 0.0369942755669108 327 24020461
SGTC_1415 3966-0071 78.1 µM 1.78345823281433 0.0472027424802468 no 267 0.0372558705875385 249 2893185
SGTC_800 3448-7362 155 µM 1.78229754595833 0.0473098552818502 no 268 0.0373503613455567 589 15991913
SGTC_1373 2887-0003 58.5 µM 1.77894027477261 0.0476207745136586 no 269 0.0376247771279181 304 776948
SGTC_1805 st050013 60.3 µM 1.77785862211397 0.0477212949885497 no 270 0.0377135387757653 240 4037144
SGTC_558 k064-0027 21.3 µM 1.77325203387014 0.0481513000540967 no 271 0.0380934766663235 303 5088526
SGTC_3205 9113483 49.47 µM 1.76434572933131 0.048991453288455 no 272 0.0388368946438779 336 17018033
SGTC_1041 0206-0046 107 µM 1.76420301124807 0.0490050109616997 no 273 0.0388489029751342 290 50494
SGTC_2740 felodipine 17.08 µM 1.7626505130458 0.0491526860890629 no 274 0.0389797259878562 225 3333 L-type calcium channel blocker
SGTC_978 1416-0512 87.4 µM 1.76205288479483 0.0492096277206396 no 275 0.0390301813309316 331 6814003
SGTC_2387 9077560 195.08 µM 1.76087934998306 0.0493215946324394 no 276 0.0391294128628497 310 5303272
SGTC_2027 5150920 200 µM 1.75713129697608 0.0496805589775025 no 277 0.039447716135062 271 786715
SGTC_585 0kpi-0023 191 µM 1.75486426979363 0.0498986899841254 no 278 0.0396412635355576 273 64601
SGTC_3233 9132340 49.47 µM 1.75412587065387 0.0499699026757183 no 279 0.0397044708201136 286 17682950
SGTC_2140 5586273 200 µM 1.75336479412654 0.0500433872151878 no 280 0.0397697050341063 237 854421
SGTC_2006 4011487 200 µM 1.74581676297567 0.0507768491160125 no 281 0.0404213985910761 388 45595294
SGTC_1771 st048882 4.1505 µM 1.74007038318653 0.0513409585647316 no 282 0.040923329989966 301 4580403
SGTC_263 alizarin 107.927 µM 1.7379094122698 0.051554381785246 no 283 0.0411133884723087 405 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2748 diazoxide 86.69 µM 1.72836853355854 0.0525051098203323 no 284 0.0419610865952548 233 3019 A potassium channel activatior.
SGTC_3007 9078383 71.4286 µM 1.72664552698102 0.052678278059639 no 285 0.0421156721192312 311 6496995
SGTC_3017 9080681 49.47 µM 1.72550703409535 0.0527929490592153 no 286 0.0422180686207538 279 16451914
SGTC_2919 7978188 46.38 µM 1.72388033760152 0.0529571363024504 no 287 0.042364723794724 322 2980291
SGTC_1021 4476-0760 85.3 µM 1.72063929699465 0.0532854711333212 no 288 0.0426581489562276 331 746768
SGTC_1436 4092-1007 8.32 µM 1.71110352561426 0.0542608598378464 no 289 0.0435310017299489 303 2881121
SGTC_1982 st072467 71.9 µM 1.70990705360026 0.0543842349294688 no 290 0.0436415309505659 381 3163533
SGTC_2662 daunorubicin 22.37 µM 1.70446494693995 0.0549482042292581 no 291 0.0441471296791521 279 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2268 7933382 153.85 µM 1.70262868493174 0.0551395367535801 no 292 0.044318789223857 396 935025 YOR257W CDC31
SGTC_538 2922-0838 53.3 µM 1.70191267215849 0.0552142854236973 no 293 0.0443858699513699 381 777039
SGTC_2949 9072542 2.23 µM 1.69676798099499 0.0557537252749507 no 294 0.0448702672310612 381 16457352
SGTC_2067 5224629 34.075 µM 1.69672340003269 0.0557584178631953 no 295 0.0448744832673193 343 2835000
SGTC_1740 st038286 13.222 µM 1.68692829274917 0.0567970288510201 no 296 0.0458085705156058 348 716786
SGTC_2150 5556613 200 µM 1.68571089496912 0.056927171685543 no 297 0.0459257486844196 351 743190
SGTC_454 lyso-paf C-16 6.67 µM 1.68382821720298 0.0571288968242613 no 298 0.0461074361330988 319 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1931 st074438 57.1 µM 1.68179642393772 0.0573472302287955 no 299 0.0463041612075241 306 2787313
SGTC_1418 3966-3099 2.4 µM 1.67950203973918 0.0575945699906808 no 300 0.0465271208345133 356 740335
SGTC_1230 0170-0365 3.77 µM 1.67946207530279 0.0575988856691856 no 301 0.0465310120494985 491 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1874 staurosporine 7.6 µM 1.67745938858872 0.0578154776453309 no 302 0.0467263422517247 347 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2814 7977482 42.97 µM 1.67645643949836 0.0579241876613954 no 303 0.0468244108924755 429 6456762
SGTC_1478 0453-0656 35.7 µM 1.6689615716471 0.0587416531456493 no 304 0.0475624979229364 347 5258496
SGTC_1449 4112-4002 201 µM 1.66315035132917 0.0593816934340004 no 305 0.0481411715283047 327 2059539
SGTC_637 1181-0519 7.26 µM 1.66151606507275 0.0595626731037005 no 306 0.0483049225744377 471 6252091 YGR060W ERG25
SGTC_1438 4092-1045 4 µM 1.66118004577106 0.0595999371585322 no 307 0.0483386459555472 323 1351342
SGTC_3210 9128157 49.47 µM 1.66078567023098 0.0596436961380416 no 308 0.0483782500716028 373 17590849
SGTC_2070 5230947 200 µM 1.65836932563399 0.0599123579494592 no 309 0.0486214720062476 335 2835538
SGTC_2870 9038528 12.99 µM 1.65522302232811 0.0602635998945569 no 310 0.0489396334359223 309 6463316
SGTC_1106 tegaserod maleate 11.7 µM 1.64918506683097 0.0609421679916828 no 311 0.0495548631591103 381 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1962 st076595 64.5 µM 1.64892645767306 0.0609713643188763 no 312 0.0495813510292389 362 279619
SGTC_1006 4099-6547 255 µM 1.64714708921322 0.0611725471175111 no 313 0.0497639081057911 347 3146833
SGTC_3040 9091894 49.47 µM 1.64421295254855 0.0615054253722974 no 314 0.0500661111886788 282 25236966
SGTC_2186 6124449 200 µM 1.64121311253337 0.0618472185701022 no 315 0.0503765923687916 323 3834182 YLR033W RSC58
SGTC_1284 0929-0043 16 µM 1.63880643275684 0.0621224991144258 no 316 0.050626789526502 376 1239883
SGTC_1286 0929-0070 131 µM 1.63857211461544 0.0621493518467734 no 317 0.0506512018965594 376 1420408
SGTC_2306 7482397 179.52 µM 1.63640358214592 0.0623982943597507 no 318 0.0508775749926781 339 891448
SGTC_19 0279-0214 38.434 µM 1.63338578264473 0.0627460238836266 no 319 0.0511939426447181 439 3566274 YBR002C RER2
SGTC_3290 9121031 71.43 µM 1.63046367502672 0.0630841644462249 no 320 0.051501768223564 311 17014854
SGTC_2402 5553605 200 µM 1.62998151301724 0.0631400954445336 no 321 0.0515527021283 372 6758546
SGTC_2193 5925765 200 µM 1.62852614431321 0.0633091530507973 no 322 0.0517066851189578 277 877370
SGTC_2142 5622915 118.518 µM 1.62701526356908 0.0634850316113995 no 323 0.0518669280408109 308 5322196
SGTC_2064 5220758 200 µM 1.62450431133232 0.0637781673072979 no 324 0.0521341104999498 405 788518
SGTC_1630 st005209 31.3 µM 1.62445899239714 0.0637834676249756 no 325 0.0521389427687517 401 3367314
SGTC_2316 5844804 197.44 µM 1.62365952537945 0.0638770263714931 no 326 0.052224246871394 468 776813
SGTC_3043 9092303 49.47 µM 1.61929060957368 0.0643901913990636 no 327 0.0526923750869285 343 25236084
SGTC_3044 9093193 49.47 µM 1.61816226582443 0.0645232437490578 no 328 0.0528138162681719 400 25236277
SGTC_1849 st056239 19.2 µM 1.61494549151915 0.0649037327297589 no 329 0.0531612497782912 386 5393181
SGTC_1238 0333-0287 48.8 µM 1.61415779582168 0.0649971685260305 no 330 0.0532466018607376 359 7226
SGTC_1471 k673-0312 37 µM 1.60703439965598 0.0658468875886822 no 331 0.0540234111087785 351 24099884
SGTC_1632 st005650 90 µM 1.60440149397888 0.0661631257279722 no 332 0.054312790961919 360 2759605
SGTC_2082 5219693 150 µM 1.59111883256552 0.0677764740740193 no 333 0.0557914175025334 392 2834649
SGTC_720 r052-1644 49.9 µM 1.58979056602393 0.06793946593403 no 334 0.055941010539917 334 1422863 YOR257W CDC31
SGTC_2439 5492030 7.2 µM 1.58895224422642 0.0680424922665853 no 335 0.056035587397634 347 5722370
SGTC_2707 st078556 66.6 µM 1.5827231149851 0.068811808701411 no 336 0.0567422937075135 347 17250899
SGTC_1430 4049-0248 69.1 µM 1.58017886227572 0.0691279538725345 no 337 0.0570329555423673 420 22774488
SGTC_1353 1498-1206 8.11 µM 1.57988421277067 0.0691646387932304 no 338 0.0570666926441175 454 6756808
SGTC_813 k007-0158 173 µM 1.57582561134423 0.0696714768541191 no 339 0.0575329991446772 448 6523916
SGTC_1618 st003135 44.5 µM 1.57407041757759 0.0698915490550621 no 340 0.0577355853640992 334 1270615
SGTC_708 3448-5400 146 µM 1.573365360047 0.0699801020347027 no 341 0.0578171215486346 412 3462195
SGTC_199 4063-0024 41.6 µM 1.57145881143928 0.0702199908074736 no 342 0.0580380572424311 344 306215
SGTC_844 0330-0132 15.3 µM 1.56912182172255 0.0705149013873226 no 343 0.0583097779954193 375 2828079
SGTC_7 0192-1582 4.227 µM 1.56701353817711 0.0707817670130485 no 344 0.0585557636015031 474 252616
SGTC_1548 st061468 90.8 µM 1.56683675507199 0.070804179357335 no 345 0.0585764268739715 365 390799
SGTC_1440 4100-1550 40 µM 1.55716678291564 0.0720384514162318 no 346 0.0597154463044632 312 742806
SGTC_203 k066-0004 30.888 µM 1.55677633446955 0.0720886324188509 no 347 0.0597617988958179 486 6795412
SGTC_2296 7971656 126.45 µM 1.55536739147371 0.072269934654452 no 348 0.0599292978013157 417 666570
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.55165470819141 0.072749354809375 no 349 0.0603724326570377 467 688788
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.54331293058767 0.0738354102021358 no 350 0.0613774338821449 379 5355888
SGTC_1073 triclabendazole 3.09 µM 1.54318744607495 0.0738518417104596 no 351 0.061392651186765 458 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.54240441691759 0.0739544382150814 no 352 0.0614876744551743 407 4330530
SGTC_1028 k015-0029 4.8 µM 1.54088864658368 0.074153351643727 no 353 0.0616719447446181 444 4588309
SGTC_3288 9119690 36.221 µM 1.53997830503936 0.0742730113611926 no 354 0.0617828208843509 359 17595618 YKL019W RAM2
SGTC_1202 1988-0068 29.6 µM 1.53831632204812 0.0744918507576864 no 355 0.0619856453978009 409 2850480
SGTC_2286 7945697 125 µM 1.53663424989491 0.0747138362033116 no 356 0.0621914502163706 435 1245733
SGTC_367 0335-0881 7.1 µM 1.53276076852472 0.0752269443061933 no 357 0.0626674050927387 446 23828853
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.532643832886 0.0752424760810541 no 358 0.06268181760856 425 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2903 5923464 63.88 µM 1.52783641621724 0.0758831314188359 no 359 0.0632765791075012 361 2876576
SGTC_1836 st055642 81 µM 1.5250611660594 0.0762548587381009 no 360 0.0636219210648076 425 8571
SGTC_695 3505-6186 243 µM 1.52172439157866 0.0767036315976045 no 361 0.0640390766237468 410 1819379
SGTC_424 splitomicin 100 mM 1.52040493181293 0.0768816428012704 no 362 0.0642046178678705 398 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_77 0828-0286 12.516 µM 1.5193683846866 0.0770217057746584 no 363 0.0643348976354133 437 745345
SGTC_3299 9121982 43.1275 µM 1.51875389821989 0.0771048294997679 no 364 0.0644122270970835 419 17594604 YPL160W CDC60
SGTC_2678 equilin 100 µM 1.51862730576038 0.0771219625683892 no 365 0.0644281669722495 424 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2467 5474540 200 µM 1.51724784063809 0.077308847432224 no 366 0.0646020608895508 424 5413519
SGTC_2035 5154463 94.595 µM 1.51160001630568 0.0780775828010592 no 367 0.0653178237734941 444 2769623
SGTC_2420 aureobasidin a 50 nM 1.50575292071761 0.078879536499751 no 368 0.0660653065604947 473 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_577 r071-0003 38.6 µM 1.50439474369726 0.0790667061640652 no 369 0.066239878444089 560 4568517 YMR134W ERG29
SGTC_2411 st077133 39.94 µM 1.50192676172653 0.0794076780756721 no 370 0.0665580121464124 488 1403142 YNL221C POP1
SGTC_1428 4049-0204 61.7 µM 1.49903202362851 0.0798090267189327 no 371 0.0669326622820006 426 X1428
SGTC_923 1900-2434 73.3 µM 1.49400380237287 0.0805098221527997 no 372 0.0675873127222061 421 5910570
SGTC_884 0851-0618 334 µM 1.48828423747655 0.0813126118239981 no 373 0.0683379750382023 454 9642473
SGTC_1342 1486-1464 234 µM 1.48785854421242 0.0813726020876906 no 374 0.0683941012138895 437 3253938
SGTC_527 4476-4215 268 µM 1.48525613684783 0.0817400690093176 no 375 0.0687379932122893 441 4418754
SGTC_2721 ifenprodil 61.44 µM 1.4837445697535 0.0819540798682012 no 376 0.0689383486813794 418 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2289 7946404 165.07 µM 1.48176829754262 0.0822345211875931 no 377 0.0692009786212121 540 1246120 YPR165W RHO1
SGTC_623 k072-0108 16.9 µM 1.48091916589821 0.0823552382822489 no 378 0.0693140575556185 440 5382803
SGTC_1519 esterone 74 µM 1.47981223492194 0.0825128058037854 no 379 0.0694616813049939 450 698 A steroid.
SGTC_2831 7999036 19.48 µM 1.47800883192874 0.0827699994322383 no 380 0.0697027071468968 461 2988270
SGTC_3162 9099653 49.47 µM 1.47693917511386 0.0829228340619732 no 381 0.0698459712712272 370 25237511
SGTC_250 brefeldin a 552.239 µM 1.47494428119287 0.0832084353680267 no 382 0.0701137620033541 358 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1383 3049-0032 20.7 µM 1.47319256464434 0.083459831217147 no 383 0.0703495597024208 444 712864
SGTC_222 nsc-310342 10.666 µM 1.47192827545422 0.0836416287934188 no 384 0.0705201235650477 286 432556
SGTC_331 k048-0133 24.5 µM 1.46756542373507 0.0842712670771383 no 385 0.0711111529119556 385 6813582
SGTC_3226 9131256 49.47 µM 1.46460277989906 0.0847008536615548 no 386 0.0715146615627448 277 17178073
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.46091147011056 0.0852383928695054 no 387 0.0720198692167135 416 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2066 5222451 176 µM 1.46013785207274 0.0853513726336115 no 388 0.0721260957173442 516 2281147
SGTC_1050 3232-1156 69.3 µM 1.45833658015488 0.0856148663627967 no 389 0.0723738960492024 463 700529
SGTC_2514 salinomycin 42.74 µM 1.45751849024942 0.0857347391576175 no 390 0.0724866555668639 515 23682228 A polyether potassium ionophore.
SGTC_2007 4011539 71.82 µM 1.45582172255253 0.0859837630161282 no 391 0.0727209545644902 475 45595301
SGTC_3292 9120825 59.784 µM 1.45231467104744 0.0865001855762749 no 392 0.0732070649913147 431 24824900
SGTC_829 1635-0120 117 µM 1.44950475201137 0.0869156240113536 no 393 0.0735983371140517 483 285054
SGTC_1032 k061-1018 98.7 µM 1.44646631986543 0.0873665228279841 no 394 0.0740232260265479 533 4005393
SGTC_1778 st046819 58.9 µM 1.44532373239743 0.0875365321262178 no 395 0.0741834873879201 524 671715
SGTC_2241 6772625 37.8075 µM 1.44424147073071 0.0876977929120922 no 396 0.074335531608484 446 2285411
SGTC_2235 salicylic acid 500 µM 1.44390856241998 0.087747441964609 no 397 0.0743823488832609 404 338 A COX inhibitor and kinase inhibitor.
SGTC_2236 dapsone 200 µM 1.44302517320618 0.0878792899014633 no 398 0.0745066900449945 457 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2905 7799065 20.05 µM 1.44268598791777 0.0879299533491419 no 399 0.0745544740944479 407 1296806
SGTC_2009 4012297 12.05 µM 1.442439714844 0.0879667523266851 no 400 0.0745891834289176 447 45595307
SGTC_916 4466-0038 42 nM 1.44100828595781 0.0881808687905942 no 401 0.0747911709578813 592 5722064 YGL116W CDC20
SGTC_3136 9095672 49.47 µM 1.43974882881027 0.088369582400232 no 402 0.0749692366279746 392 17217380
SGTC_2767 sibutramine 71.45 µM 1.43708892528244 0.0887691237425731 no 403 0.0753463638096224 463 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2136 5328288 199.296 µM 1.43298864962353 0.0893876546214967 no 404 0.0759305405253255 372 262395
SGTC_1949 st076024 69.1 µM 1.42005304339243 0.0913600126216278 no 405 0.0777961196020569 485 2921930
SGTC_651 3253-0966 34.4 µM 1.41612920601714 0.0919646311640262 no 406 0.0783688392191989 506 781462
SGTC_2888 9058547 12.99 µM 1.41301704475132 0.0924462828922238 no 407 0.0788253562523519 385 16476514
SGTC_3348 9149464 3.537 µM 1.4121232919149 0.0925849483760495 no 408 0.0789568308326632 470 1951442
SGTC_949 1165-0505 146 µM 1.41163923296325 0.0926601141787897 no 409 0.0790281071293318 511 6244267
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.41151494421496 0.0926794213059166 no 410 0.0790464161524104 560 551469
SGTC_272 doxorubicin 8.13 µM 1.41144434399569 0.0926903897331653 no 411 0.0790568177283198 523 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.41128200123831 0.0927156148934744 no 412 0.0790807397238742 435 2374 Ca(2+)-ATPase inhibitor.
SGTC_1456 k015-0012 13 µM 1.40842612629493 0.0931601973544322 no 413 0.0795024637345969 541 2989616
SGTC_994 3910-0338 138 µM 1.40343895590788 0.0939403392362665 no 414 0.0802429916233537 512 3479481
SGTC_1003 4049-0218 100 µM 1.40337334663792 0.0939506345123751 no 415 0.0802527683433639 499 295161
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.40295820742901 0.0940157966345728 no 416 0.080314650896354 499 688751
SGTC_803 4488-1585 147 µM 1.40134682795835 0.0942690419809084 no 417 0.0805551921565917 448 747204
SGTC_2595 hexamethylquercetagetin 100 µM 1.39969588834324 0.0945290260767133 no 418 0.0808022027952476 459 386331
SGTC_1776 st049249 45.9 µM 1.39814646030279 0.0947735049875208 no 419 0.0810345452711009 500 1822314
SGTC_801 0866-0028 10.1 µM 1.39780177869514 0.0948279544110245 no 420 0.0810863000496331 512 6849771
SGTC_2041 5107442 45.335 µM 1.39578083818306 0.0951476666401429 no 421 0.0813902511793715 486 793005
SGTC_88 0180-0332 8.668 µM 1.39571199628612 0.0951585713731672 no 422 0.0814006201729181 480 3101745
SGTC_683 panaxydol 45 µM 1.39518613705721 0.0952418991917384 no 423 0.081479858172792 504 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1557 sumaresinolic acid 42.3 µM 1.3947102946174 0.0953173476288068 no 424 0.0815516096185167 469 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_685 1278-0033 54.9 µM 1.38556298378592 0.0967762874805867 no 425 0.0829401938892223 519 3590572
SGTC_590 k048-0076 22.4 µM 1.3848380365359 0.0968926096219806 no 426 0.0830509986957797 478 6832814
SGTC_98 0074-0023 107.663 µM 1.38459107987688 0.0969322587332214 no 427 0.0830887702814058 526 3563821
SGTC_763 3453-1109 128 µM 1.38383667191849 0.0970534533723114 no 428 0.0832042356610827 496 1560353
SGTC_1351 1496-0003 46.5 µM 1.37873318449425 0.0978762441918284 no 429 0.083988517009992 504 3891978
SGTC_3242 9133940 49.47 µM 1.37759716221535 0.0980600888399704 no 430 0.0841638487967801 475 17248444
SGTC_743 1275-0778 158 µM 1.37700768938627 0.0981555840001107 no 431 0.0842549352527562 519 2849257 YMR203W TOM40
SGTC_381 3461-2219 42.7 µM 1.37618759350446 0.0982885536145024 no 432 0.0843817810585404 515 2883159
SGTC_3084 9116877 49.47 µM 1.3727482166602 0.09884764809643 no 433 0.0849153170215433 415 27241325
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.36848440034148 0.0995439870310963 no 434 0.0855802508219635 523 165521
SGTC_869 0564-0080 44.1 µM 1.36703155617972 0.0997820731199068 no 435 0.0858077073205049 522 6843321
SGTC_2238 6671620 73.2395 µM 1.3575389619764 0.101347924808533 no 436 0.0873050111645799 486 729941
SGTC_90 0870-0863 4.608 µM 1.356993681378 0.101438412262522 no 437 0.0873916091077938 554 1738164
SGTC_2558 carylophyllene oxide 100 µM 1.35178919341529 0.102305042003504 no 438 0.0882213810774782 539 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_957 1187-1561 14.1 µM 1.3512059731426 0.102402491940484 no 439 0.0883147308619271 529 1538454
SGTC_805 3852-0218 479 µM 1.34976369214683 0.102643771658249 no 440 0.0885458973227808 515 6615355
SGTC_435 c-PAF 6.7 µM 1.34569166340717 0.103327212542954 no 441 0.0892009880233332 531 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.34519763021445 0.103410354249042 no 442 0.0892807106571302 556 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_900 1112-0045 141 µM 1.34399920849039 0.103612240483143 no 443 0.0894743214265816 392 56211 YIL048W NEO1
SGTC_2398 5228213 48.84 µM 1.3409448178631 0.104128076417856 no 444 0.0899691847498998 610 80771 YMR134W ERG29
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.33701504335724 0.104794485433182 no 445 0.0906088632299893 537 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1037 k284-1091 78.7 µM 1.33640471577321 0.104898260903693 no 446 0.0907085128929048 458 3334711
SGTC_602 3130-1533 38.1 µM 1.33336611761304 0.105416028461184 no 447 0.0912058428912244 572 720941
SGTC_2060 5238662 140 µM 1.3289681106094 0.106168705290256 no 448 0.0919292454883733 505 790130
SGTC_933 2914-0560 114 µM 1.32645456022383 0.106600614892816 no 449 0.092344588412171 586 463887
SGTC_1936 st074407 74.3 µM 1.3239668237688 0.107029336242032 no 450 0.0927570316101879 571 809813
SGTC_157 1348-1695 65.819 µM 1.322475957664 0.107286858252981 no 451 0.0930048550658574 610 5380510
SGTC_1417 3966-0327 90.4 µM 1.32130110979214 0.107490107931215 no 452 0.0932004920478887 577 651118
SGTC_804 1595-0054 20.9 µM 1.32016013996404 0.107687762152492 no 453 0.0933907785270315 506 761523 Stimulates phospholipase C.
SGTC_2319 6033012 152.6 µM 1.3155185056583 0.108494548061108 no 454 0.0941678510568836 469 847246
SGTC_1746 st038117 42 µM 1.310925644735 0.109297127580641 no 455 0.0949414428984012 548 2898218
SGTC_2302 7771753 200 µM 1.30480104893945 0.110373993714603 no 456 0.0959803009389807 578 2203047
SGTC_472 calcifediol 10 µM 1.29714723002323 0.111730404377873 no 457 0.0972902667381716 464 5283731 A vitamin D metabolite.
SGTC_339 3091-4833 71.4 µM 1.2965208250854 0.111841941507624 no 458 0.0973980550532291 532 3240077
SGTC_1054 3429-0080 167 µM 1.29414792128275 0.112265180863146 no 459 0.0978071657509457 578 1162877
SGTC_686 1319-0111 510 µM 1.29290955151327 0.112486514783384 no 460 0.098021171805185 593 4562600
SGTC_2597 laccaic acid a 100 µM 1.2867948884183 0.113583958676584 no 461 0.0990828945277629 575 5491415 A textile dye.
SGTC_3261 9137475 49.47 µM 1.28593124588752 0.113739576143628 no 462 0.0992335288906474 338 17027690
SGTC_1806 st050005 60.3 µM 1.28134276741548 0.114568910592439 no 463 0.100036648626209 563 5194765
SGTC_2084 5306078 60.6385 µM 1.27972134995218 0.114862996747396 no 464 0.100321576588155 554 679340
SGTC_21 0849-0113 22.993 µM 1.2788753877488 0.11501664695416 no 465 0.100470470493739 577 1560156
SGTC_2182 6325192 200 µM 1.2745709754568 0.115800711644651 no 466 0.101230568060194 536 736248
SGTC_2746 daunorubicin 9.88 µM 1.27152766592701 0.116357347510046 no 467 0.101770495782599 394 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_725 1497-0963 19 µM 1.27091736417961 0.116469202746803 no 468 0.10187902415523 580 3549977
SGTC_444 curcumin 90.4 µM 1.26895797507816 0.116828832244465 no 469 0.102228026535749 595 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.26659924898273 0.117262799965781 no 470 0.102649310567194 595 442882
SGTC_517 1365-0151 113 µM 1.26420133812505 0.117705146202683 no 471 0.103078885340736 565 768657
SGTC_2463 5473429 200 µM 1.26312718058096 0.117903680197725 no 472 0.103271738635425 554 5399405
SGTC_1845 st056753 3.01 µM 1.26003831905374 0.118475906999854 no 473 0.103827769635858 590 5375839
SGTC_822 1487-0950 154 µM 1.25855572122315 0.118751261615356 no 474 0.104095424450957 566 1958375
SGTC_2968 9090663 33.37 µM 1.25764182173359 0.118921220124829 no 475 0.104260660627825 562 25236811
SGTC_1016 4226-1401 38 µM 1.25606300853215 0.119215237672408 no 476 0.104546563239935 592 2901613
SGTC_2207 7258803 200 µM 1.25302428199549 0.119782573704619 no 477 0.105098434951609 512 3666799
SGTC_518 1021-0119 62.6 µM 1.25147462941312 0.120072628641224 no 478 0.105380682133453 569 1097762
SGTC_632 0781-2353 4.65 µM 1.25133076113983 0.12009958215541 no 479 0.105406913482566 612 6811515 YHR007C ERG11
SGTC_2433 5607874 27.82 µM 1.24422640538632 0.12143588030978 no 480 0.106708124033213 581 2252428
SGTC_2643 anethole 100 µM 1.24375824691626 0.121524304529402 no 481 0.106794275748037 612 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_926 2268-1401 59.4 µM 1.24354090008217 0.12156537165843 no 482 0.10683428952138 585 2931578
SGTC_109 0132-0036 33.701 µM 1.24287038170974 0.121692125852434 no 483 0.106957800796407 441 67274 A color developer.
SGTC_3332 9141069 11.198 µM 1.24236251609807 0.121788194105987 no 484 0.107051419531221 518 17332883
SGTC_1495 4469-0029 237 µM 1.24233909674866 0.121792625413153 no 485 0.107055738023285 714 793680
SGTC_1910 st062352 60.4 µM 1.2404418088929 0.1221519983421 no 486 0.107406012519086 585 2245730
SGTC_2421 5690543 90.72 µM 1.23870834576289 0.122480990867487 no 487 0.107726763430051 595 3397993
SGTC_872 0588-0139 234 µM 1.23797213849972 0.12262090297186 no 488 0.107863195916549 595 2047100
SGTC_141 0443-0274 32.331 µM 1.23652484643445 0.122896279572586 no 489 0.108131767946316 707 1627241
SGTC_2543 pimpinellin 60.67 µM 1.2304082237771 0.124064878587284 no 490 0.109272137664316 566 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.22907665085796 0.124320306748896 no 491 0.109521534274678 521 6857784
SGTC_382 3229-0966 23.2 µM 1.22877458829583 0.124378300858518 no 492 0.109578165840784 633 5722370
SGTC_1880 MG-132 525 µM 1.22806269367781 0.124515054969556 no 493 0.109711717076298 548 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_865 0488-0499 301 µM 1.22629421153522 0.124855233123781 no 494 0.110043989427165 649 9634651
SGTC_2784 7567673 72.73 µM 1.22562500656261 0.124984127913761 no 495 0.110169911518685 634 3471247
SGTC_489 paxilline 115 µM 1.21721168817475 0.126612540408313 no 496 0.111761842129667 560 105008 A toxic potassium channel blocker.
SGTC_2791 5663188 71.43 µM 1.21354760918815 0.127326328438273 no 497 0.112460261801783 565 54690634
SGTC_859 0439-0102 54.6 µM 1.21308591806776 0.127416467249448 no 498 0.112548486661847 672 610143
SGTC_2842 9000675 19.48 µM 1.21107997539407 0.127808615075501 no 499 0.112932377563241 564 2989072
SGTC_2350 9023895 38.85 µM 1.20506326920065 0.128989867079598 no 500 0.114089439065108 609 2997209
SGTC_1270 0831-1170 17.3 µM 1.20133283814004 0.129726048586171 no 501 0.114811058585562 674 6764716
SGTC_1705 st027868 56.3335 µM 1.19929349762073 0.130129729867285 no 502 0.115206921292863 598 292948
SGTC_976 1348-1067 47.6 µM 1.19900449736924 0.130187006840958 no 503 0.115263098430333 692 5310671 YGL099W LSG1
SGTC_1785 bathophenanthroline 24 µM 1.19660518619423 0.130663200054405 no 504 0.11573023904588 616 72812 An iron chelator.
SGTC_167 3672-0051 66.205 µM 1.19571346234882 0.130840487766982 no 505 0.115904198006146 583 3237971
SGTC_1002 4049-0206 172 µM 1.1920273952645 0.131575095286122 no 506 0.11662525180033 678 4662749
SGTC_2129 girgensonine 121.053 µM 1.19077824504124 0.131824686819093 no 507 0.116870325733203 676 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_796 1234-0020 70.7 µM 1.18771158748465 0.132438817406118 no 508 0.117473528496291 619 46495034
SGTC_2809 7964133 12.99 µM 1.18650498942029 0.132680991043463 no 509 0.117711466133109 650 1253665
SGTC_3148 9097893 49.47 µM 1.18518816808361 0.132945635247067 no 510 0.117971528500076 604 17174100
SGTC_1503 4585-0012 61.3 µM 1.18365286108414 0.133254647529778 no 511 0.118275253038904 605 2922052
SGTC_1726 st035556 14.5795 µM 1.18232723202346 0.133521855076199 no 512 0.118537942127299 685 5919439
SGTC_1108 betulinic acid 729.144 nM 1.18062737898202 0.133865033989907 no 513 0.118875391091889 642 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2368 9071271 200 µM 1.18006327066266 0.133979054207633 no 514 0.118987525723545 616 27209959
SGTC_1883 5-benzylidenerhodanine 20 µM 1.17930499688731 0.134132425173757 no 515 0.119138374620001 702 1273210
SGTC_2229 7354935 190 µM 1.17883436358688 0.134227677661512 no 516 0.119232068985161 567 318112
SGTC_3062 9077494 49.47 µM 1.17409180302802 0.13519012779663 no 517 0.120179128185374 624 16459633
SGTC_2248 tofa 1.1 µM 1.17135019353353 0.135748660168599 no 518 0.1207290217541 606 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3010 9080089 71.4286 µM 1.17130717639177 0.13575743637943 no 519 0.120737663932707 657 17027233
SGTC_113 0099-0221 2.5 µM 1.17104566113796 0.13581079819353 no 520 0.120790211929664 621 89219
SGTC_1212 0520-0165 585 µM 1.17057170449296 0.135907544973035 no 521 0.120885488205298 639 5403258
SGTC_2053 5265679 138 µM 1.17039146690492 0.135944348496825 no 522 0.120921734016088 660 764595
SGTC_2560 caryophyllene 100 µM 1.16547113748438 0.13695168895106 no 523 0.121914168335398 688 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1654 st012436 41.8 µM 1.16388107184441 0.137278311384273 no 524 0.122236105655111 601 4323132
SGTC_922 1866-0035 480 µM 1.15995022429312 0.138088046087861 no 525 0.123034536253634 758 3156169
SGTC_1564 D-Arginine 115 µM 1.15723193306105 0.138649901625977 no 526 0.123588807214808 638 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_3122 9126309 49.47 µM 1.15576621040888 0.138953503657458 no 527 0.123888398787676 631 17591206
SGTC_1241 0364-0022 50.8 µM 1.15558289860628 0.138991505713434 no 528 0.123925903184382 683 4563895
SGTC_2874 9043904 71.43 µM 1.15520055465912 0.139070791550575 no 529 0.124004153826595 550 4463428
SGTC_1043 0916-0009 19.3 µM 1.15491453744181 0.139130122447376 no 530 0.124062712810022 767 3101130
SGTC_3354 9151612 71.43 µM 1.15395055534742 0.139330216026097 no 531 0.12426022038694 691 27261949
SGTC_1974 st069448 26.9 µM 1.15151530616193 0.139836571953927 no 532 0.124760150996745 636 6323587 YNR016C ACC1
SGTC_515 4092-1064 102 µM 1.14469855859882 0.141260607852094 no 533 0.126167024374919 733 717353
SGTC_3277 9138724 49.47 µM 1.14338476319223 0.14153618903536 no 534 0.12643943792388 552 15943418
SGTC_2671 danthron 100 µM 1.14158953658776 0.141913343631634 no 535 0.12681233766724 662 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_561 1550-0330 72.9 µM 1.1405887888803 0.142123883306448 no 536 0.127020542412508 637 6812934
SGTC_1609 st001574 46.4 µM 1.14037514376467 0.142168857841762 no 537 0.127065021903657 678 3960012
SGTC_1832 st054113 55 µM 1.1395878271658 0.142334679376545 no 538 0.127229029547278 642 1251267
SGTC_960 1222-0186 7.7 µM 1.13928882642093 0.142397688010201 no 539 0.1272913536157 700 3126296
SGTC_1250 0485-0349 40.2 µM 1.13673206553997 0.142937246464392 no 540 0.127825155152017 625 6842794 YDL195W SEC31
SGTC_3323 9138564 53.9225 µM 1.13611344965951 0.143068001543112 no 541 0.12795454341324 738 43912313 YNL103W MET4
SGTC_1624 st003710 6.25 µM 1.13043685232707 0.144271620506699 no 542 0.129146096482731 727 24207033
SGTC_974 1326-0144 138 µM 1.13038575953672 0.144282484704552 no 543 0.129156855992624 708 5411856
SGTC_2255 7941087 197.44 µM 1.12726108632794 0.14494795287331 no 544 0.129816054953196 771 935561
SGTC_3116 9124943 49.47 µM 1.1252295612561 0.145381717735015 no 545 0.130245884748378 616 41905195 YPL160W CDC60
SGTC_1388 3346-4487 254 µM 1.1240623244457 0.145631337051118 no 546 0.130493293483619 731 3345614
SGTC_307 1501-1223 22.3 µM 1.1206327461899 0.146366435589379 no 547 0.131222110121 678 2830329
SGTC_3252 9135871 49.47 µM 1.12001402738155 0.14649931707574 no 548 0.131353892263989 682 17682838
SGTC_2960 9079389 5.97 µM 1.11720170555095 0.147104336352998 no 549 0.131954045769812 713 16457355
SGTC_3088 9117578 49.47 µM 1.11712470695675 0.147120924710881 no 550 0.131970503936623 676 678341
SGTC_1464 k208-0027 110 µM 1.11621077633704 0.147317915107799 no 551 0.132165961387455 710 X1464
SGTC_1483 3453-0561 55.9 µM 1.11408229674375 0.147777376747412 no 552 0.13262194132487 725 4546991
SGTC_1081 sertraline 6 µM 1.11402070497679 0.147790686448207 no 553 0.132635152119914 719 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_89 0302-0250 142.109 µM 1.11138510737038 0.148360979209108 no 554 0.133201309948187 738 4203518 YLR208W SEC13
SGTC_2204 7233102 200 µM 1.11071384514492 0.148506462350634 no 555 0.133345770411595 623 2172480
SGTC_416 estradiol valerate 100 µM 1.11058270558882 0.148534895455313 no 556 0.133374005168718 678 13791 A steroid.
SGTC_1670 st016595 4.04 µM 1.11010936949816 0.148637552393246 no 557 0.133475950122078 700 597879
SGTC_2158 5657123 3.6195 µM 1.11000450920724 0.148660300866447 no 558 0.133498541699676 695 2858827
SGTC_87 0100-0052 35.5 µM 1.10907359944655 0.148862355196448 no 559 0.133699216434759 906 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1772 st048439 82.2 µM 1.10532406888568 0.149678049746151 no 560 0.134509596129919 704 2927068 YDL195W SEC31
SGTC_1925 st057770 10.1 µM 1.10006918180474 0.150826237565656 no 561 0.135650990113074 633 5989122
SGTC_336 4111-0029 111 µM 1.09602455235904 0.151713968341558 no 562 0.136534014980966 644 3131175
SGTC_3112 9123419 49.47 µM 1.09503059653677 0.151932656026791 no 563 0.136751616153428 741 17015854
SGTC_1096 rimcazole 32.2 µM 1.09482311671263 0.151978331626183 no 564 0.136797068441337 678 18528119 A dopamine reuptake inhibitor.
SGTC_1885 st057546 99.9 µM 1.0935502249077 0.152258751721685 no 565 0.137076144916159 740 702008
SGTC_51 1013-0126 23.419 µM 1.09342188852443 0.152287043481896 no 566 0.137104303729763 682 1627850
SGTC_2272 7805186 180 µM 1.09147940039466 0.1527156912127 no 567 0.137530995653752 717 2956062 YPR165W RHO1
SGTC_2964 9083345 53.42 µM 1.09072692387811 0.152881954617467 no 568 0.137696529917478 651 17741579
SGTC_368 fentichlor 4.58 µM 1.08986690654103 0.153072126628904 no 569 0.137885888094745 629 7329 A pesticide.
SGTC_1086 cerivastatin 2.18 µM 1.08912652468922 0.153235969696583 no 570 0.138049047226575 687 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_572 0960-0087 17.7 µM 1.0883728847172 0.153402866029659 no 571 0.138215263247747 759 6796365
SGTC_2450 5739737 12.93 µM 1.08584959067233 0.153962534927675 no 572 0.138772771096126 666 2262825
SGTC_2485 5633444 17.78 µM 1.08529989593616 0.154084636721532 no 573 0.138894425991074 700 5724239
SGTC_2304 7443016 91.4 µM 1.08514281678668 0.154119539935856 no 574 0.138929203072356 656 939854
SGTC_3157 9099274 49.47 µM 1.0848381508998 0.154187252045197 no 575 0.138996672529976 705 17217662
SGTC_2861 9024595 19.48 µM 1.08410079612677 0.15435121085031 no 576 0.139160054952311 606 16482810
SGTC_1152 3909-8331 15.9 µM 1.08174707028737 0.154875358305274 no 577 0.13968246572501 687 16001939
SGTC_1390 3413-2614 145 µM 1.07778956033643 0.155759297131659 no 578 0.140563839743022 739 3421432
SGTC_205 1486-1330 71.903 µM 1.07714417434428 0.155903763691573 no 579 0.140707930393646 685 4118834
SGTC_2763 lisinopril 49.32 µM 1.07713146996209 0.155906608392827 no 580 0.140710767814561 683 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_278 4092-0821 23.9 µM 1.07556349857394 0.156257963363299 no 581 0.14106125967482 733 877900
SGTC_594 1487-1584 10.8 µM 1.07191435992928 0.157077689617066 no 582 0.141879249860437 721 5013332
SGTC_2482 5981709 142.65 µM 1.07148882189833 0.157173464393548 no 583 0.141974847070995 755 877755
SGTC_3263 9137018 49.47 µM 1.07102416017207 0.157278088491643 no 584 0.142079283223492 691 43844957
SGTC_2401 5128683 200 µM 1.0680757756929 0.157943019000357 no 585 0.142743166016357 661 708373
SGTC_3090 9117696 49.47 µM 1.06582449325839 0.15845197745737 no 586 0.143251493302916 733 7923821
SGTC_120 rhodamine 6G 52.259 µM 1.06424550619381 0.1588095879633 no 587 0.143608748558345 886 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2704 st078022 71.1 µM 1.06280813481908 0.159135584843916 no 588 0.143934484845641 759 54697681
SGTC_1422 4031-0024 15.5 µM 1.06112101501843 0.159518783683261 no 589 0.14431745428638 737 782427
SGTC_371 0195-0006 7.36 µM 1.05965957552701 0.159851211114624 no 590 0.144649749865274 662 3928593
SGTC_1995 st072814 61.1 µM 1.05677636354902 0.160508371028787 no 591 0.145306832045413 722 5769371
SGTC_1048 3161-0300 24.5 µM 1.05612952563267 0.160656044473663 no 592 0.145454521354481 759 2165101
SGTC_1187 1391-0724 117 µM 1.05170824842968 0.161667799716121 no 593 0.14646671273187 776 6997986
SGTC_2783 7738165 71.43 µM 1.04789750129073 0.162543167754142 no 594 0.147342916818046 643 17201110
SGTC_2690 usnic acid 100 µM 1.04740882338429 0.162655644811152 no 595 0.147455531994418 820 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2101 5377231 179.231 µM 1.04642547023375 0.162882132722777 no 596 0.147682319170653 745 2844213
SGTC_3224 9130643 49.47 µM 1.04500418239981 0.163209848855369 no 597 0.148010518255605 711 17644395
SGTC_1258 0671-0043 57.1 µM 1.04459298831385 0.16330474056436 no 598 0.148105560812356 741 4298767
SGTC_2840 9008771 71.43 µM 1.04398575094878 0.163444938932764 no 599 0.148245991084976 705 2992978
SGTC_1001 4048-4355 44.4 µM 1.04279751336986 0.163719504145933 no 600 0.148521041631182 746 21824233
SGTC_1491 4138-0063 26.5 µM 1.03779025324349 0.164879815372484 no 601 0.149683857754324 736 23883227
SGTC_283 0987-0079 11.7 µM 1.03530895328365 0.165456765182011 no 602 0.150262324941822 814 411556
SGTC_2729 fluphenazine 10.66 µM 1.03446497935333 0.165653302597441 no 603 0.150459420279296 783 3372 An atypical antipsychotic.
SGTC_2756 carbadox 75.1 µM 1.03355004295337 0.165866535609953 no 604 0.150673282131747 746 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2655 perillic acid 100 µM 1.03350044185218 0.1658781005982 no 605 0.150684881925156 713 5702197 An apoptosis inducer.
SGTC_967 1306-0166 352 µM 1.03323082898361 0.165940972626045 no 606 0.150747944425826 778 4437607
SGTC_2320 7373003 200 µM 1.03114582242215 0.166427703041536 no 607 0.151236221192541 741 5415828
SGTC_977 1348-1378 135 µM 1.02997798010834 0.166700730106599 no 608 0.151510171218605 795 X977
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.0295683806137 0.16679655781805 no 609 0.151606332318191 726 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2899 9053889 58.44 µM 1.02892024198022 0.166948265470625 no 610 0.151758577788683 760 6470052
SGTC_581 0958-0271 211 µM 1.02889110727268 0.16695508702413 no 611 0.15176542381364 811 4591145
SGTC_778 3456-2434 196 µM 1.02702469115378 0.167392461303802 no 612 0.15220441885196 875 5539063
SGTC_1650 st011916 45.8 µM 1.02683040927033 0.167438031536616 no 613 0.152250163805573 780 242528
SGTC_1763 st044482 94.5 µM 1.02626740822827 0.167570132677635 no 614 0.152382777668007 791 88505
SGTC_987 1497-1013 404 µM 1.02581693828389 0.167675878141348 no 615 0.152488940233421 756 1676435
SGTC_532 1548-0774 215 µM 1.02515130930216 0.167832209714498 no 616 0.152645899300873 810 5932993
SGTC_3259 9138485 49.47 µM 1.02504593569585 0.167856966669321 no 617 0.152670756814451 843 17646153
SGTC_3138 9097216 49.47 µM 1.02145462945291 0.168702129822308 no 618 0.153519547142988 803 25237486
SGTC_2725 haloperidol 53.21 µM 1.02113871271313 0.168776607009899 no 619 0.153594362017248 774 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1079 idarubicin 2.36 µM 1.02068836034312 0.168882813840793 no 620 0.153701055445276 757 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2192 5915882 198.485 µM 1.02065128493201 0.168891559266563 no 621 0.153709841203263 737 2876149
SGTC_372 0155-0182 15.9 µM 1.01934131895144 0.16920074352696 no 622 0.154020477165934 833 771486
SGTC_1120 ficusin 1.78878 µM 1.01745102800372 0.1696475389058 no 623 0.154469458864305 800 6199 A DNA cross-linker.
SGTC_2887 9044784 58.44 µM 1.01498412685682 0.170231760970842 no 624 0.155056697010646 879 6465546
SGTC_2770 toltrazuril 17.5 µM 1.01243763983254 0.17083618131279 no 625 0.155664424545191 833 68591 Kills coccidiodes.
SGTC_1303 1160-0052 261 µM 1.01115426209655 0.171141316701284 no 626 0.155971301442962 801 3562476
SGTC_2713 st079149 53.4 µM 1.00972359897009 0.17148188117991 no 627 0.156313866433461 801 3103253
SGTC_2405 ticlatone 3.52 µM 1.00883382905988 0.171693906162274 no 628 0.156527167069544 760 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_3322 9139058 2.11 µM 1.00630317458469 0.17229785569655 no 629 0.157134876928274 804 4908926 YPR165W RHO1
SGTC_583 1488-1091 88.9 µM 1.00478463824102 0.172660909583678 no 630 0.157500281228394 940 4303273
SGTC_2766 oltipraz 83.91 µM 1.00393579991669 0.172864063442743 no 631 0.157704779695511 766 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_160 3453-0671 289.699 µM 1.0016415685774 0.173413907440285 no 632 0.158258368418279 869 5322268
SGTC_2834 9001755 58.44 µM 1.00089505642641 0.173593059110723 no 633 0.158438773403981 726 2989575
SGTC_2663 amphotericin b 100 µM 0.997169007177114 0.174489014829041 no 634 0.159341240954273 769 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_204 PMA1.184 62.41 µM 0.997024855405764 0.174523736083844 no 635 0.159376222723055 858 2252213 YGL008C PMA1
SGTC_2468 5987765 72.9 µM 0.996355211352263 0.174685088074452 no 636 0.159538793305852 839 26772094
SGTC_1220 1838-0075 193 µM 0.996277217388728 0.174703887022151 no 637 0.159557735082747 820 5529645
SGTC_2288 7946289 167.31 µM 0.996002512202853 0.17477010966187 no 638 0.159624462279878 871 1246052
SGTC_2775 cyproheptadine 69.59 µM 0.995535781127323 0.174882660135506 no 639 0.159737875346023 808 2913 A selective serotonin reuptake inhibitor.
SGTC_1972 st070201 17.4 µM 0.994302467558948 0.175180290455386 no 640 0.160037817374735 816 2829099
SGTC_1754 st042065 16.137 µM 0.99417868199493 0.175210180829665 no 641 0.160067942364518 896 1126236 YIL048W NEO1
SGTC_2298 7976326 193.81 µM 0.99260737145194 0.17558988467461 no 642 0.160450665522831 737 2235818
SGTC_767 0929-0023 86 µM 0.992353120393063 0.17565137287976 no 643 0.160512649452162 889 1204563
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.991247203064903 0.175918987198273 no 644 0.160782443293393 843 5106787 A p450 inhibitor.
SGTC_2801 7907800 81.82 µM 0.989134029196048 0.176431059116456 no 645 0.161298785137424 807 6620925
SGTC_2996 9066192 71.4286 µM 0.988857086773279 0.176498238621079 no 646 0.161366534495472 787 6472854
SGTC_3101 9120531 49.47 µM 0.988494429011429 0.176586235047617 no 647 0.161455280745501 827 24824904
SGTC_1196 1588-0294 184 µM 0.98681562108302 0.176993947720455 no 648 0.161866517664545 768 6144269
SGTC_730 1436-0052 41.2 µM 0.986183060741178 0.177147724496829 no 649 0.162021645048243 784 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1889 st059080 5.18 µM 0.984097323037836 0.177655369481354 no 650 0.162533831513563 867 176925 Isolated from Daphnopsis sellowiana.
SGTC_1510 1123-0200 71.5 µM 0.983033833942075 0.17791456369967 no 651 0.162795393480606 886 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2237 6667747 47.222 µM 0.978766143609217 0.178957084903239 no 652 0.163847770905976 782 729940 YDL015C TSC13
SGTC_584 0986-0246 15.4 µM 0.970322815901333 0.181030939604464 no 653 0.165942804010778 906 53315 YDR232W HEM1
SGTC_3097 9117246 49.47 µM 0.967736872399705 0.181669100670042 no 654 0.166587899106841 832 16423892
SGTC_1175 0741-0056 27.6 µM 0.967222356442036 0.181796240998683 no 655 0.166716444183585 915 765927
SGTC_908 3448-7491 47.7 µM 0.965250508044669 0.182284013141049 no 656 0.167209677188576 896 1203031
SGTC_2116 5511452 16.8835 µM 0.964079378787859 0.182574099751645 no 657 0.167503065191596 858 870744
SGTC_633 0437-0093 97.7 µM 0.963180419334229 0.182796965867576 no 658 0.167728494834416 836 2831118
SGTC_2932 9016711 44.54 µM 0.960784415315843 0.183391801809162 no 659 0.168330288115653 888 7117328
SGTC_2263 7948595 193.29 µM 0.959229372374723 0.183778504362221 no 660 0.168721603279082 784 2971371
SGTC_1119 parthenolide 318.541 nM 0.958905742823413 0.183859047219217 no 661 0.168803115721633 897 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2539 epi(13)torulosol 80 µM 0.958636664162445 0.183926030534756 no 662 0.168870907716153 802 6708597
SGTC_375 3970-0961 9.27 µM 0.957184288783171 0.184287841110921 no 663 0.169237122831182 848 2898222
SGTC_2658 polymyxin b sulfate 77.05 µM 0.957143927917362 0.184297901986599 no 664 0.169247307062237 854 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2097 5376186 200 µM 0.954656533560953 0.184918601792459 no 665 0.169875708891486 854 742755
SGTC_1725 st036284 20.55 µM 0.954252224429082 0.185019614947582 no 666 0.16997799252231 921 707914
SGTC_3295 9122362 53.5725 µM 0.950413506672653 0.185980392713869 no 667 0.170951091828146 795 4730473
SGTC_2576 guaiol 23.12 µM 0.950214406821034 0.186030308879926 no 668 0.171001659861474 911 227829
SGTC_1944 st076371 56.9 µM 0.948169314897564 0.186543512952988 no 669 0.171521632854114 818 24208455
SGTC_3185 9108267 49.47 µM 0.946520975147877 0.186957791808127 no 670 0.171941464543457 847 4910486
SGTC_1850 st056238 17 µM 0.946004262512796 0.187087774805675 no 671 0.172073206071509 910 5393177
SGTC_831 k061-1017 217 µM 0.944766023787745 0.187399490592375 no 672 0.172389170674493 997 1240153
SGTC_1767 st044992 70.3 µM 0.939674487333869 0.188684611364914 no 673 0.173692277765684 843 9600693
SGTC_6 0844-0013 19.835 µM 0.938916954695666 0.188876278325098 no 674 0.173886691757037 1065 1584900
SGTC_1115 galangin 695.678 nM 0.934266872174552 0.190055444532512 no 675 0.175083124141807 954 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1846 st056244 14.8 µM 0.933161321040475 0.190336454084042 no 676 0.175368340974268 886 5393182
SGTC_2507 purpurin 79.67 µM 0.9317419326355 0.190697608885488 no 677 0.17573495507373 874 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1755 st041960 45.185 µM 0.931336931561702 0.190800736035267 no 678 0.175839651850035 861 2257073
SGTC_481 bay k-8644 50 µM 0.925899091125869 0.192188708755039 no 679 0.177249211844495 817 2303 A calcium channel antagonist.
SGTC_833 3852-0053 558 µM 0.925053468579842 0.192405101905006 no 680 0.177469047750707 937 3123681
SGTC_247 mechlorethamine 29.705 µM 0.924583855841603 0.19252533919782 no 681 0.177591206946828 836 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2965 9082772 38.63 µM 0.923427593805311 0.192821578448222 no 682 0.177892208633242 916 16459634
SGTC_860 0443-0016 25.1 µM 0.922325857975358 0.193104106774452 no 683 0.178179315061142 944 5337942
SGTC_12 0849-0099 9.267 µM 0.921211018594537 0.193390252483019 no 684 0.178470133325957 865 6071388
SGTC_699 0375-0592 111 µM 0.919580809141169 0.193809143631714 no 685 0.178895929563102 936 762578
SGTC_2400 5203494 178.7 µM 0.918094556271516 0.194191525941775 no 686 0.179284682293766 817 6777674
SGTC_2741 miltefosine 3.04 µM 0.917123590199045 0.194441583524137 no 687 0.179538940365541 791 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2063 5246145 200 µM 0.915706578350916 0.194806864992138 no 688 0.179910406890057 917 711240
SGTC_2994 9053520 71.4286 µM 0.915089033812502 0.19496618793475 no 689 0.180072445734243 896 4647384
SGTC_2170 morpholine 200 µM 0.914425335856452 0.19513750649539 no 690 0.18024669699252 899 121171 Reacts with secondary amines.
SGTC_2614 arthonioic acid 13.39 µM 0.913581160912357 0.195355543246043 no 691 0.180468484609952 851 6710684
SGTC_591 4299-0174 154 µM 0.913204032372814 0.195452997264814 no 692 0.180567621788314 899 5509088
SGTC_1360 1598-0022 39.8 µM 0.91277986704982 0.195562641362183 no 693 0.180679164502832 967 761525
SGTC_275 trichlorophene 5.69 µM 0.911995107832409 0.195765595184836 no 694 0.180885646440611 985 62616
SGTC_2636 apigenin dimethyl ether 100 µM 0.910452461372112 0.196164925688557 no 695 0.181291970801215 882 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2275 7947463 200 µM 0.910290267502796 0.196206939981963 no 696 0.181334724931258 876 1225414
SGTC_3113 9123498 49.47 µM 0.905984461974035 0.197324299194825 no 697 0.182472038348785 940 8897275
SGTC_3086 9117350 49.47 µM 0.905625964914372 0.197417502646279 no 698 0.182566930441675 864 2679265
SGTC_1015 4130-4525 82 µM 0.904476554565995 0.197716510255298 no 699 0.182871380455292 902 1363237
SGTC_480 am 92016 50 µM 0.902830315134164 0.198145239371821 no 700 0.183307979612788 842 2129 K+ channel blocker.
SGTC_1851 st056236 18.9 µM 0.902295454203564 0.198284653586137 no 701 0.183449969857282 950 5393171
SGTC_1398 3558-0053 112 µM 0.901819122386638 0.198408861716864 no 702 0.183576480001337 847 4532369
SGTC_940 3232-1287 54.8 µM 0.90171239947725 0.198436697184535 no 703 0.183604832256284 915 1585493 YIL048W NEO1
SGTC_1824 st053723 68.6 µM 0.897047277142682 0.199655755657442 no 704 0.18484684507512 956 675225
SGTC_1621 st003705 32.4 µM 0.896559510758706 0.199783475184546 no 705 0.184977005779042 970 24207032
SGTC_1272 0839-0021 27 µM 0.896401629292443 0.199824826292736 no 706 0.185019148724307 914 5027250
SGTC_2935 9038016 29.96 µM 0.895956444856954 0.199941453321244 no 707 0.185138012927278 944 6463195
SGTC_3175 9106517 49.47 µM 0.894701974782571 0.200270312759855 no 708 0.185473211385062 888 41468073
SGTC_2028 5153890 36.43 µM 0.892583264415842 0.200826470321378 no 709 0.18604019234813 890 2830968 YPR165W RHO1
SGTC_1063 disulfiram 1.84 µM 0.89020887067526 0.20145084444127 no 710 0.186676871193271 918 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1365 1672-3266 55.4 µM 0.889398266989146 0.201664268075957 no 711 0.186894538009368 946 6415873
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.888868415368113 0.201803845740043 no 712 0.187036900908066 963 6708739 YPR165W RHO1
SGTC_620 0109-0052 432 µM 0.888418392293564 0.201922439761559 no 713 0.187157867786196 954 493037
SGTC_1954 st077032 68.9 µM 0.887985602227228 0.202036531736076 no 714 0.187274248036079 825 698907
SGTC_1578 josamycin 24.2 µM 0.887234799812083 0.202234549517575 no 715 0.187476250127073 848 5282165 A P450 substrate.
SGTC_3080 9117754 49.47 µM 0.886853508291012 0.202335156365043 no 716 0.187578887490214 979 9550191
SGTC_2322 7413319 38.22 µM 0.886181527208698 0.202512536847399 no 717 0.187759858164376 957 1840400
SGTC_2625 euphol 100 µM 0.885101192526824 0.202797903786183 no 718 0.188051028170448 938 6708538 A triterpene alcohol.
SGTC_155 k072-0202 43.6 µM 0.883740013461084 0.20315779670662 no 719 0.188418287460766 914 5857737
SGTC_3056 9094900 49.47 µM 0.883054642828927 0.203339151503513 no 720 0.188603374427225 921 25236784
SGTC_525 k781-2675 26.7 µM 0.882949189584973 0.203367063885885 no 721 0.188631862427172 936 3651118 YDL195W SEC31
SGTC_2174 5790901 200 µM 0.882404802244389 0.203511193941543 no 722 0.188778969857899 888 786020
SGTC_1761 st044296 37 µM 0.880358317045596 0.20405355887279 no 723 0.189332614900718 954 1826700
SGTC_3009 9080819 71.4286 µM 0.878816833866592 0.204462654831733 no 724 0.189750298676148 930 17027216
SGTC_556 4058-0063 51.5 µM 0.877944291649771 0.204694435996094 no 725 0.189986975664218 973 6615692
SGTC_874 0599-0792 117 µM 0.87749985212871 0.204812556484913 no 726 0.19010759956323 1009 765305
SGTC_2391 6285546 200 µM 0.876788234595074 0.205001770346478 no 727 0.190300835366308 955 846083
SGTC_3160 9100216 49.47 µM 0.875882701929406 0.205242694996482 no 728 0.190546902126942 950 17191039
SGTC_3303 9125618 40.5795 µM 0.875371070866706 0.205378893123694 no 729 0.190686017557863 980 22695467
SGTC_3169 9102970 49.47 µM 0.874992859686602 0.205479608871592 no 730 0.190788895416529 973 17027839
SGTC_1256 0570-0116 285 µM 0.873428303552716 0.205896553840356 no 731 0.191214834702309 892 410638
SGTC_1295 1013-0063 9.78 µM 0.872240248842917 0.206213498399538 no 732 0.191538663238627 972 6826038
SGTC_3179 9107801 49.47 µM 0.871168641002241 0.206499625652642 no 733 0.191831039807278 950 4818259
SGTC_148 3253-0744 288.01 µM 0.870734777153898 0.20661553737742 no 734 0.191949492515776 948 6893655
SGTC_652 0437-0092 114 µM 0.870464742898128 0.20668769959017 no 735 0.192023239368484 938 3091274
SGTC_1820 st053765 18.6 µM 0.86969235148291 0.206894190867721 no 736 0.192234276597275 926 3690829
SGTC_3235 9132602 49.47 µM 0.8668755797595 0.207648261046381 no 737 0.193005092518826 961 4912240
SGTC_2054 5233173 129 µM 0.866268704988112 0.20781093817397 no 738 0.193171411960456 954 6889
SGTC_1612 st002233 45.4 µM 0.865989033855099 0.207885931352913 no 739 0.193248087768207 939 1035021
SGTC_106 0092-0003 11.579 µM 0.865026312040031 0.208144205180956 no 740 0.193512173604551 903 1072148
SGTC_3075 9116269 49.47 µM 0.864441620187959 0.208301155549735 no 741 0.193672668799961 947 17015205 YNL244C SUI1
SGTC_1232 0279-0259 161 µM 0.863859821892198 0.208457398472487 no 742 0.193832450266211 948 1560000
SGTC_1574 spiramycin 23.7 µM 0.863026469743306 0.208681316965939 no 743 0.194061456843976 985 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_3213 9129884 49.47 µM 0.862512391028666 0.208819518598696 no 744 0.194202808714033 894 17190742
SGTC_1656 st012921 11 µM 0.859557259024513 0.20961500278466 no 745 0.195016571973801 898 6732821
SGTC_1403 3909-7815 62.9 µM 0.85947951950276 0.20963595331213 no 746 0.195038007278384 924 6615483
SGTC_2867 9039098 71.43 µM 0.857907126284434 0.210059972041345 no 747 0.195471874440398 913 6463460
SGTC_2581 avocatin a 64 µM 0.857449719815133 0.210183412901067 no 748 0.19559819562541 949 6710728 A skin care supplement.
SGTC_72 0744-0168 198.391 µM 0.856383803961851 0.210471238231333 no 749 0.195892760112493 926 677577
SGTC_816 0325-0417 81.3 µM 0.855799042423021 0.210629237458166 no 750 0.196054472494688 958 68101
SGTC_232 clozapine 119 µM 0.855789823466967 0.210631728924514 no 751 0.196057022591224 952 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_138 0850-0259 40.9225 µM 0.854410689188423 0.21100464121075 no 752 0.196438737671902 1012 6813004
SGTC_1077 5-fluorocytosine 377 nM 0.853600936801518 0.211223775174019 no 753 0.196663069650235 931 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2802 7925815 54.55 µM 0.852802985619589 0.211439845898335 no 754 0.196884283988148 943 1262923
SGTC_1884 5633444 25 µM 0.852616014036382 0.211490493127681 no 755 0.196936139506839 960 5724239
SGTC_1611 st001856 99.4 µM 0.852314705977944 0.211572126992295 no 756 0.19701972300098 923 647478
SGTC_2052 5265182 7.135 µM 0.852010693827028 0.21165451217432 no 757 0.197104078373733 973 1239884
SGTC_3306 9127676 59.7925 µM 0.851482705502543 0.211797637960291 no 758 0.197250633172884 946 41905287
SGTC_145 3737-0113 38.366 µM 0.850341836455403 0.212107095276911 no 759 0.197567531560408 1078 6849351
SGTC_1652 st011932 78 µM 0.849599108905033 0.212308699905003 no 760 0.197774003774537 958 1551076
SGTC_3341 9147222 25.867 µM 0.849056961824024 0.212455930013234 no 761 0.197924798539422 914 1939759
SGTC_466 geldanamycin 89.2 µM 0.84450447872071 0.213694592745858 no 762 0.199193780850566 888 5288382 HSP90 inhibitor.
SGTC_592 k241-0073 46.5 µM 0.843888186352265 0.213862599393089 no 763 0.199365945143666 1017 4230158
SGTC_1149 3909-7961 23.3 µM 0.84231365912156 0.214292178270916 no 764 0.199806203703004 960 735261
SGTC_1279 0874-0590 65.2 µM 0.839365551161467 0.215097860026988 no 765 0.200632104457214 977 3523074
SGTC_487 nimodipine 119 µM 0.839218989458058 0.215137959377676 no 766 0.200673216546953 902 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2517 totarol 10 µM 0.83847101145885 0.215342674084964 no 767 0.200883110949075 944 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2592 piperlongumine 83.33 µM 0.838388513657318 0.215365259893911 no 768 0.200906269194205 929 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_729 4092-0585 94.1 µM 0.832844961574812 0.216886090495137 no 769 0.202466086776124 957 2169061
SGTC_2330 7979373 200 µM 0.830859206996557 0.217432373503497 no 770 0.203026585369088 969 1863007
SGTC_44 0929-0055 61.211 µM 0.83040409354236 0.217557687457786 no 771 0.203155175971453 941 1379590
SGTC_2195 6536160 144.242 µM 0.829767566089226 0.217733023044281 no 772 0.20333510595008 939 3834386
SGTC_45 0kpi-0036 14.9 µM 0.829383321676608 0.217838905089419 no 773 0.203443767999048 948 2795021
SGTC_354 2783-3500 4.88 µM 0.827516107518478 0.218353855554034 no 774 0.203972298121848 959 6740761
SGTC_2902 5787006 60.46 µM 0.825592436850576 0.218885108498461 no 775 0.204517663441591 962 591003
SGTC_282 k297-0036 65.7 µM 0.825428940359535 0.218930294973744 no 776 0.204564055071196 990 5061378
SGTC_1674 st016616 23.6 µM 0.824185359594761 0.21927416619854 no 777 0.204917122212048 991 625830
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.82285161315168 0.219643314545414 no 778 0.205296190826701 1096 6708561
SGTC_679 0422-0091 41.4 µM 0.818548791405413 0.220836660073687 no 779 0.206521946869597 1072 627384 YHR062C RPP1
SGTC_1660 st012960 28.1 µM 0.81631228936419 0.221458395413462 no 780 0.20716077368231 976 24207266
SGTC_3111 9122088 49.47 µM 0.816052024639565 0.221530812530635 no 781 0.207235190658753 922 16876704
SGTC_1188 1403-0014 4.57 µM 0.815191334722733 0.221770390771997 no 782 0.207481398580868 1048 9614867
SGTC_1789 tunicamycin 25 nM 0.814726462391245 0.22189985233297 no 783 0.207614451278501 1020 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_676 falcarinol 140 µM 0.810932518193326 0.22295803401965 no 784 0.208702212367032 1081 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1311 1190-0148 100 µM 0.808158006296968 0.223733698604835 no 785 0.209499814352501 1121 1961333
SGTC_2860 9025725 38.96 µM 0.807628481206765 0.223881910989764 no 786 0.209652242948694 966 40546248
SGTC_968 1309-0633 340 µM 0.80438383083276 0.224791295799099 no 787 0.210587668192107 1031 3761976
SGTC_2863 9028737 58.44 µM 0.803771122599409 0.224963255588265 no 788 0.21076458507329 1028 6460917
SGTC_2941 9056145 11.23 µM 0.803040088746943 0.225168521595261 no 789 0.21097578198809 960 2119517
SGTC_2385 9074692 200 µM 0.803021357032218 0.225173782641894 no 790 0.210981195241911 1009 17046906
SGTC_1144 3486-0183 12.5 µM 0.799475195069153 0.226171022142254 no 791 0.212007462050961 1046 6744069
SGTC_2144 5628481 200 µM 0.799051521269796 0.226290332902716 no 792 0.212130269088649 1036 2818399
SGTC_1957 st077035 62.4 µM 0.798179072846039 0.2265361350239 no 793 0.212383289913781 1081 705593
SGTC_1843 st055809 45.5 µM 0.79285452506858 0.228039526913725 no 794 0.213931292317475 989 16413835
SGTC_2878 9043973 25.97 µM 0.792578981423472 0.22811747937352 no 795 0.214011579306454 1041 6465167
SGTC_261 5-fluorouridine 15.376 µM 0.792407931908121 0.228165877540112 no 796 0.214061427965933 1017 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2001 4023502 57.655 µM 0.792276238319931 0.228203143948001 no 797 0.214099811800617 1026 108941 YCR052W RSC6
SGTC_2447 5741742 33.78 µM 0.791311009800736 0.228476386957091 no 798 0.214381262630787 1055 1776504
SGTC_616 4092-0450 108 µM 0.79093155683404 0.228583855220827 no 799 0.214491966155155 1076 787165
SGTC_2460 5552655 174.22 µM 0.788515863315498 0.229268690683653 no 800 0.215197511683223 1067 5401989
SGTC_2675 theaflavin digallate 100 µM 0.788403080449663 0.229300692072391 no 801 0.215230484771635 1055 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2293 7624732 200 µM 0.788329132653248 0.229321675627419 no 802 0.215252105668579 1055 894453
SGTC_3140 9094243 49.47 µM 0.787838057478657 0.229461051279369 no 803 0.21539571847125 1133 19291112
SGTC_2776 terbinafine 19.92 µM 0.78417674458423 0.230501690463473 no 804 0.216468204380493 1089 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2133 5320837 200 µM 0.783973605249597 0.230559505015691 no 805 0.216527799080691 1009 2841355
SGTC_3177 9107506 49.47 µM 0.781953629548061 0.231134841754384 no 806 0.217120912799523 1037 8897194
SGTC_1856 st057054 55.7 µM 0.781463944115415 0.231274436272037 no 807 0.217264837515906 1096 1266018
SGTC_1216 1165-0504 9.65 µM 0.780632362601106 0.23151160274027 no 808 0.217509375994525 1070 6304004
SGTC_2079 5212404 121 µM 0.7803962791002 0.23157895829208 no 809 0.217578828679097 1081 758462
SGTC_1738 st035555 74 µM 0.78027891198958 0.231612447655058 no 810 0.217613361313621 1074 5331140
SGTC_2665 lovastatin 100 µM 0.779941000456666 0.231708881918401 no 811 0.217712801847627 1081 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1219 1469-0211 33.1 µM 0.776230990369459 0.23276912635545 no 812 0.218806305529202 1055 6822282
SGTC_2167 5876490 200 µM 0.775757861828488 0.232904530298765 no 813 0.218945984244809 1084 686534
SGTC_2308 7584454 197.62 µM 0.774456734004531 0.233277123627373 no 814 0.219330372260991 1090 893577
SGTC_3355 9151058 44.0485 µM 0.772239622054671 0.233912781234605 no 815 0.219986259174858 1109 17015728
SGTC_815 1582-0027 36.9 µM 0.772074819045182 0.233960069408952 no 816 0.220035057644789 1088 3128206
SGTC_3151 9099821 49.47 µM 0.771041701791958 0.234256630187824 no 817 0.220341106988938 1072 17174189
SGTC_609 0986-0026 86.3 µM 0.768991795555742 0.234845680243924 no 818 0.220949090542512 1062 2848610
SGTC_3218 9131285 49.47 µM 0.76796546117664 0.235140909460808 no 819 0.221253852384574 1098 17156417
SGTC_1608 st001473 40.5 µM 0.76686245579998 0.235458421784757 no 820 0.221581648969449 1032 7292267
SGTC_1693 xanthone 101.9 µM 0.766600009799223 0.235534004604694 no 821 0.221659684826232 1102 7020 An insecticide.
SGTC_1136 pergolide 1.05886 µM 0.766110407075011 0.235675042924526 no 822 0.221805305571269 1038 47811 A dopamine receptor agonist.
SGTC_2676 harmalol 100 µM 0.765235117766335 0.235927300797062 no 823 0.222065775790797 1095 5459187 A monoamine oxidase inhibitor
SGTC_1709 st033179 39.1045 µM 0.764664435672114 0.236091851158121 no 824 0.222235694422028 1101 573381
SGTC_2659 sanguinarine 24.21 µM 0.762848539990649 0.236615866602714 no 825 0.222776864462177 1060 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_3223 9129970 49.47 µM 0.759119474952328 0.237693971352479 no 826 0.223890545117326 1125 17248386
SGTC_2069 5228469 200 µM 0.756934698845495 0.238326858714562 no 827 0.224544492886073 1071 2835210
SGTC_2617 dihydrotanshinone i 20.83 µM 0.756648221978942 0.238409913910138 no 828 0.224630321512821 1140 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2151 5563267 85.4165 µM 0.755644726578839 0.23870097163135 no 829 0.224931116006981 1085 5310824
SGTC_663 1486-0733 13.9 µM 0.755332786353311 0.238791487587736 no 830 0.225024665573506 1083 722445 YPR165W RHO1
SGTC_1919 st067113 52.3 µM 0.755096909887351 0.238859944524168 no 831 0.225095418574397 1061 1268243
SGTC_218 alverine citrate 93.75 µM 0.750868822528854 0.240088854375119 no 832 0.226365802648807 1071 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1667 st014849 34.6 µM 0.750195670713159 0.240284826110649 no 833 0.226568432924546 1147 5348460
SGTC_2567 aureobasidin a 60 nM 0.750181630963662 0.240288914368997 no 834 0.226572660220428 1106 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_661 1304-0007 33.6 µM 0.750037588606736 0.240330860494969 no 835 0.226616033199913 1089 3117130
SGTC_2716 st080858 38.6235 µM 0.749609754386227 0.240455472282863 no 836 0.226744887135371 1122 5296050
SGTC_2491 paeonol 100 µM 0.748615277748248 0.240745261301351 no 837 0.227044560553256 1092 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1722 st034304 3.6505 µM 0.748382648522036 0.240813076531902 no 838 0.227114692750929 1145 4036148 YLR033W RSC58
SGTC_2825 7998094 58.44 µM 0.74749363699165 0.241072333689569 no 839 0.227382821138817 1063 2987815
SGTC_1027 k015-0025 8.67 µM 0.747276854575703 0.241135575666484 no 840 0.227448230361762 1138 3598955
SGTC_2062 5245942 200 µM 0.746825613899121 0.241267245119003 no 841 0.227584416081146 1211 1376160
SGTC_66 0109-0187 42.4 µM 0.74650094838477 0.241362004825666 no 842 0.227682429451631 1034 759417
SGTC_473 2-arachidonoylglycerol 10 µM 0.746037625558117 0.241497269274555 no 843 0.227822343262924 1046 5282280 An endocannabinoid.
SGTC_1769 st044406 64.4 µM 0.746029066273751 0.241499768495911 no 844 0.227824928443019 1106 670903
SGTC_74 000s-0487 160.283 µM 0.745038031488418 0.241789235218033 no 845 0.228124364515508 1126 677548
SGTC_755 1995-0008 37.3 µM 0.744368410009039 0.24198492837025 no 846 0.228326812424025 1145 689533
SGTC_409 arachidonic acid 100 µM 0.744274983590447 0.2420122385488 no 847 0.228355066231659 1154 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2220 6782180 200 µM 0.742804695836624 0.242442249489535 no 848 0.228799966033057 1064 833803
SGTC_164 4100-3994 89.624 µM 0.742518772551766 0.242525920717944 no 849 0.228886541092736 1157 4615967
SGTC_1723 st034307 2.5525 µM 0.740845689033485 0.243015837272382 no 850 0.229393504471422 1152 867466
SGTC_1389 3405-0187 19 µM 0.74000997656713 0.243260753039027 no 851 0.229646970392408 1087 799890
SGTC_1991 st073000 8.92 µM 0.739300075168786 0.243468903090941 no 852 0.229862401842831 1141 4301969 YIL048W NEO1
SGTC_2502 avocadyne acetate 18.59 µM 0.737962973892218 0.243861215443883 no 853 0.230268474658223 1155 3952079
SGTC_1242 0402-0103 60.1 µM 0.737246421702526 0.244071595833527 no 854 0.230486253965117 1108 432868
SGTC_853 0419-0306 21 µM 0.736399638273684 0.244320338375926 no 855 0.230743762363409 1089 762713
SGTC_2382 9035899 200 µM 0.735930256555313 0.244458278043829 no 856 0.230886571407739 1173 6462679
SGTC_1688 st021091 57.6 µM 0.735229999209802 0.244664144312932 no 857 0.231099715899133 1152 3656366
SGTC_754 3474-0146 171 µM 0.734472643779924 0.244886901694477 no 858 0.231330363472931 1104 24762078
SGTC_1162 k048-0130 20.1 µM 0.734309088011608 0.244935021907783 no 859 0.231380190149622 1103 6797406
SGTC_2859 9028643 45.46 µM 0.733141072088016 0.245278815094314 no 860 0.231736195938109 1103 17151580
SGTC_3236 9132701 49.47 µM 0.733123309556674 0.245284045310092 no 861 0.231741612229413 1127 24282524
SGTC_1018 4259-0013 28.1 µM 0.729648733075208 0.246308293826622 no 862 0.232802462864795 1117 6801262
SGTC_1448 4255-0083 152 µM 0.729361617817511 0.246393033163806 no 863 0.232890244849553 1178 5399660
SGTC_2841 9004761 38.96 µM 0.729086398914585 0.246474276069857 no 864 0.232974406926714 1091 2991039
SGTC_1613 st002381 52.1 µM 0.728310196090547 0.246703483615706 no 865 0.233211861113671 1161 551167
SGTC_2743 auranofin 4.32 µM 0.727997396166979 0.246795883614942 no 866 0.233307590110889 1098 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2957 9076800 11.52 µM 0.727928541071 0.246816225656302 no 867 0.233328665388219 1096 16459615
SGTC_2708 st078559 56 µM 0.727792828628726 0.246856322166452 no 868 0.233370207561312 1071 17250902
SGTC_2565 isoliquiritigenin 100 µM 0.727068386675069 0.247070418947432 no 869 0.233592031822343 1094 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2797 7859098 81.82 µM 0.726800214938168 0.247149697831714 no 870 0.233674175699658 1177 972681
SGTC_841 0251-0215 91.2 µM 0.726793870584951 0.247151573560405 no 871 0.233676119236944 1173 3888614
SGTC_3020 9089140 49.47 µM 0.726595421697704 0.24721024946381 no 872 0.233736916847227 1170 17217859
SGTC_244 nsc-207895 1.295 µM 0.726351391065685 0.247282412852206 no 873 0.23381169108561 1033 42640
SGTC_2189 6047310 154.431 µM 0.725382947917557 0.247568906501817 no 874 0.234108565634306 1112 711535
SGTC_1727 st034309 9.9045 µM 0.724495868739522 0.247831485840964 no 875 0.234380681273942 1189 870305
SGTC_1384 3089-0840 101 µM 0.723835818875289 0.248026959929256 no 876 0.234583268138941 1126 1069836
SGTC_3064 1327-0027 10 µM 0.72245289683703 0.248436779546587 no 877 0.235008037569866 1040 16000455 YPR107C YTH1
SGTC_3304 9125678 46.087 µM 0.721507755065539 0.248717073399723 no 878 0.235298585511009 1124 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1469 k284-2957 126 µM 0.721101695441627 0.248837547260232 no 879 0.235423473995607 1187 23884841
SGTC_1649 st011737 51.3 µM 0.720086637823363 0.249138840620567 no 880 0.235735827048016 1123 1761035
SGTC_2642 cholecalciferol 100 µM 0.719610927132727 0.249280109672745 no 881 0.235882291127053 1142 9821465 A vitamin D precursor, similar to steriods.
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.717137244486909 0.250015390931989 no 882 0.236644708354797 1195 1377
SGTC_2315 7733312 200 µM 0.716144215083211 0.250310883912686 no 883 0.236951152269884 1148 726316
SGTC_3127 9126946 49.47 µM 0.716023566206323 0.250346797671726 no 884 0.236988398766151 1075 27243249
SGTC_2862 9027634 71.43 µM 0.71485840734385 0.25069377304331 no 885 0.237348269989935 1133 5012562
SGTC_140 0062-0056 502.533 µM 0.714601448976724 0.250770327536743 no 886 0.237427674574485 1167 3758964
SGTC_2545 solidagenone 89.61 µM 0.714476257202375 0.250807629863847 no 887 0.237466366283378 1006 6708572 An anti ulcer agent
SGTC_362 0310-0100 9.03 µM 0.713670751292114 0.25104770984416 no 888 0.237715398309905 1178 790235
SGTC_770 0389-1121 67.2 µM 0.71140358764534 0.251724087173854 no 889 0.238417088222731 1217 6753108
SGTC_1207 2099-0101 141 µM 0.710408498052642 0.252021262166373 no 890 0.238725427436864 1201 5837381
SGTC_1176 0848-0131 83.3 µM 0.710199015996802 0.252083845767841 no 891 0.238790365493172 1237 6769040
SGTC_1868 st057644 42.7 µM 0.709273575484912 0.252360422904339 no 892 0.239077361556076 1199 688665
SGTC_2205 7238770 200 µM 0.708632604681176 0.252552077148031 no 893 0.239276248814621 1188 279867
SGTC_631 k072-0230 41.5 µM 0.707118086177056 0.253005232049325 no 894 0.239746548685849 1187 5773147
SGTC_2122 5258151 111.688 µM 0.707096209448809 0.253011780857921 no 895 0.239753345708306 1175 2173356
SGTC_1051 3253-3903 78 µM 0.70580722121225 0.253397797465671 no 896 0.240154015367771 1181 5509239
SGTC_2650 prasterone 100 µM 0.704891472400967 0.253672227060403 no 897 0.240438888719697 1138 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1257 0669-0121 16 µM 0.703876223228884 0.253976657053916 no 898 0.240754929890898 1221 4307855
SGTC_2108 5365811 200 µM 0.699840656535598 0.255188644558065 no 899 0.242013410621363 1205 780283
SGTC_2102 5377816 72.7585 µM 0.699589192326706 0.255264265889218 no 900 0.242091946976988 1214 1379702
SGTC_2827 7993847 71.43 µM 0.697365634661147 0.255933452587213 no 901 0.242787001127486 1135 2985692
SGTC_1695 st026914 34.495 µM 0.696816786620818 0.256098770885947 no 902 0.242958729670534 1158 3289191
SGTC_302 1094-0063 18.9 µM 0.695955677469428 0.256358257423585 no 903 0.243228293667577 1148 5440289
SGTC_1203 3992-3522 103 µM 0.695711465575368 0.256431873141663 no 904 0.243304771853788 1302 5322312
SGTC_1525 8-methoxypsoralen 92.5 µM 0.695012720454966 0.2566425650865 no 905 0.243523664908787 1231 4114 Related to psoralen; DNA damaging agent.
SGTC_1721 st082152 9.2685 µM 0.69422677165115 0.256879659151679 no 906 0.243770002966988 1176 5296051
SGTC_836 0330-0104 1.35 µM 0.69417446857993 0.256895441256194 no 907 0.243786400965883 1213 46494820
SGTC_2504 purpurogallin 52.29 µM 0.693975226204334 0.256955565941846 no 908 0.243848872660652 1138 5281571 An antioxidant.
SGTC_177 1327-0068 8.361 µM 0.693744947993911 0.257025065323927 no 909 0.243921086285932 1200 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2895 9054447 58.44 µM 0.692386401692814 0.257435281879107 no 910 0.244347351586115 1225 2697450
SGTC_855 0428-0020 25 µM 0.691173898232972 0.257801687483845 no 911 0.244728132440079 1194 6812414
SGTC_418 lividomycin a 100 µM 0.690329456402079 0.258057028587973 no 912 0.244993513927334 1218 72394 An antibiotic.
SGTC_1870 st057514 26.5 µM 0.690136184953875 0.258115488169373 no 913 0.245054274825557 1205 5393161
SGTC_2114 5491910 81.25 µM 0.686914657401985 0.259090926595869 no 914 0.246068254899089 1246 2849228
SGTC_744 1594-0068 283 µM 0.686398165305299 0.259247491068924 no 915 0.246231030559134 1236 668392
SGTC_1112 tnp00069 1.16933 µM 0.685968413715836 0.25937779911248 no 916 0.246366513407523 1233 145826
SGTC_2452 5863136 48.41 µM 0.684782034094054 0.259737705301661 no 917 0.246740736996804 1189 2184096
SGTC_452 diindolylmethane 8 µM 0.682048478547504 0.260567950654679 no 918 0.247604148609833 1175 3071 Inhibits expression of several cancer promoting factors.
SGTC_1445 4239-0156 97.7 µM 0.681518736815778 0.260729003621648 no 919 0.247771657530211 1265 4008346
SGTC_2638 epoxomicin 18 µM 0.679749218611592 0.261267346587121 no 920 0.248331632831799 1205 9915668 A protesome inhibitor.
SGTC_1180 1193-0155 285 µM 0.679041814676791 0.261482720735612 no 921 0.248555683933997 1217 2921347
SGTC_1098 clofazimine 15.1 µM 0.678021251955898 0.261793598841006 no 922 0.248879109294948 1258 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1665 st014639 11.4 µM 0.677570432659198 0.261930985241192 no 923 0.249022049221363 1291 981133 YIL048W NEO1
SGTC_2563 tomatine 8.54 µM 0.677016694520038 0.262099786558633 no 924 0.249197681077223 1228 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2104 5389443 200 µM 0.67590657749837 0.262438362038844 no 925 0.249549980687853 1266 2244536
SGTC_188 3229-0966 278.469 µM 0.673958391289896 0.26303308175305 no 926 0.250168883665945 1315 5722370
SGTC_3039 9090270 49.47 µM 0.673778518913571 0.263088025821292 no 927 0.250226066840139 1225 17173750
SGTC_918 glabranin 770.725 nM 0.672403083949632 0.263508361914178 no 928 0.250663560016017 1253 124049 Also referred to as licorice root.
SGTC_826 1683-5028 118 µM 0.670941286997606 0.263955465828753 no 929 0.251128966602242 1254 722377
SGTC_670 4204-0025 119 µM 0.670425335969526 0.264113366420667 no 930 0.251293344044834 1236 719039
SGTC_2365 9042475 200 µM 0.669386777839259 0.2644313504683 no 931 0.251624391917873 1256 6464479
SGTC_4 0960-0234 25.671 µM 0.668922711584577 0.264573500482303 no 932 0.251772390805537 1239 6821112
SGTC_615 k087-0205 167 µM 0.667962340076237 0.264867799190226 no 933 0.252078816084566 1213 9642773
SGTC_1488 4013-0813 75.9 µM 0.665072321882619 0.265754426429587 no 934 0.253002118360335 1226 2910057
SGTC_2325 6158266 200 µM 0.663748728359047 0.266160992762616 no 935 0.253425573015221 1254 3623240
SGTC_1397 3532-0190 20.1 µM 0.663491458489151 0.266240054520586 no 936 0.253507924069785 1176 5322280
SGTC_1809 st050081 57.6 µM 0.663152655676249 0.266344190349144 no 937 0.253616394939355 1307 5036894
SGTC_1314 1222-0010 41.1 µM 0.661161992515868 0.266956464819217 no 938 0.254254216348874 1252 3526027
SGTC_3003 9075612 71.4286 µM 0.660213571471053 0.267248423471577 no 939 0.254558392146762 1250 6501993
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.660160986967237 0.267264615616699 no 940 0.254575262524999 1279 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_931 2812-0076 566 µM 0.660054260937955 0.267297480876648 no 941 0.254609504612144 1275 3450959
SGTC_281 1672-3440 14.9 µM 0.659668866559077 0.267416176364145 no 942 0.254733175015879 1251 6833000
SGTC_2976 9009005 19.48 µM 0.658418375876552 0.267801491074711 no 943 0.255134665359321 1280 2993148
SGTC_2269 7935389 174.42 µM 0.657656523244397 0.268036378382872 no 944 0.25537943265642 1238 97605
SGTC_2711 st079103 59.1 µM 0.656252363645537 0.268469567363026 no 945 0.255830881066186 1249 54693780
SGTC_3034 9090421 49.47 µM 0.653249725695689 0.269397073037886 no 946 0.256797648810406 1209 17173761
SGTC_2781 5567276 71.43 µM 0.650674315231946 0.270193887293794 no 947 0.257628373361926 1267 2853274
SGTC_740 k014-0057 261 µM 0.650533692794203 0.270237428819246 no 948 0.257673772686767 1290 4012779
SGTC_432 NS 1619 61.3 µM 0.650125308516032 0.27036389847332 no 949 0.257805641267016 1279 4552 A K+/calcium channel activator.
SGTC_2670 beta-carotene 100 µM 0.650003022734169 0.270401774051723 no 950 0.257845134547237 1208 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_136 0097-0015 404.482 µM 0.649488705707815 0.270561102504073 no 951 0.258011272166151 1274 4861337
SGTC_1229 0139-0193 12.2 µM 0.648731361354168 0.270795802874859 no 952 0.258256014896272 1312 3090752
SGTC_2606 farnesol 9.78 µM 0.64760656278217 0.271144564448763 no 953 0.258619725747073 1299 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3248 9135562 49.47 µM 0.646983807629046 0.271337755812515 no 954 0.258821211637836 1301 17650701
SGTC_889 0919-1524 82.7 µM 0.646373459556241 0.271527164783722 no 955 0.259018762135449 1252 3905452
SGTC_143 4032-1194 15.74 µM 0.644979583852853 0.271959972207842 no 956 0.259470208131742 1301 1806963
SGTC_1169 aniline yellow 25.8 µM 0.643356267195181 0.2724644546619 no 957 0.259996476821474 1251 6051 A DNA damaging agent.
SGTC_1167 k781-0610 148 µM 0.642207366448224 0.272821782242174 no 958 0.260369275334638 1305 4525169
SGTC_64 000l-0018 272.079 µM 0.641940331237118 0.272904867994258 no 959 0.260455963084281 1248 6811119
SGTC_295 k015-0027 31 µM 0.639958850962976 0.273521780588675 no 960 0.26109967586813 1257 3887424
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.639074836905165 0.273797231359266 no 961 0.261387124311207 1260 688667
SGTC_2532 xanthone 78.9 µM 0.637211763292346 0.274378197042291 no 962 0.261993458213498 1241 7020 An insecticide.
SGTC_1139 k015-0024 46.9 µM 0.631516875209065 0.276157808445693 no 963 0.263851309429077 1281 2766652
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.63025433866922 0.276553107871738 no 964 0.2642640962161 1274 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1791 st048313 56.1 µM 0.629881194042172 0.276669992312242 no 965 0.264386158916786 1250 1204976
SGTC_35 0133-0054 64.071 µM 0.629408007365829 0.276818248895206 no 966 0.264540988534967 1241 99677
SGTC_588 3970-1144 52.9 µM 0.628927771378138 0.276968753910232 no 967 0.264698171886576 1232 1888707
SGTC_439 amiodarone 34.4 µM 0.625945206139656 0.277904379996015 no 968 0.265675440934501 1268 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_49 0717-0965 32.132 µM 0.625378862779704 0.278082215154603 no 969 0.265861215793541 1370 5889349 YGL099W LSG1
SGTC_3244 9134489 49.47 µM 0.623219647364779 0.278760730383204 no 970 0.266570096154665 1258 16584271
SGTC_2015 5119600 184 µM 0.622726970513341 0.278915662767287 no 971 0.266731978057437 1324 2828786
SGTC_2123 5259487 200 µM 0.622335982621262 0.279038646771611 no 972 0.266860482739016 1292 2173474
SGTC_2014 4013930 200 µM 0.622149652971281 0.279097265450661 no 973 0.266921734084759 1290 64556
SGTC_2657 nystatin 74.44 µM 0.621764057579455 0.279218591472378 no 974 0.2670485117532 1319 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2947 9072639 7.68 µM 0.620875504922265 0.279498268508255 no 975 0.267340769533602 1290 16488146
SGTC_3068 9116768 49.47 µM 0.616709014554801 0.280811506609186 no 976 0.268713337115267 1286 41904888
SGTC_641 4092-0595 30 µM 0.616572337377876 0.280854636444391 no 977 0.268758422601292 1335 786260
SGTC_1341 1486-1360 280 µM 0.616512161134622 0.280873626668572 no 978 0.268778274049028 1316 3976547
SGTC_1047 2043-3044 82 µM 0.616487448743003 0.280881425504973 no 979 0.268786426594977 1291 669592
SGTC_1680 diphenhydramine 100 µM 0.615962108387855 0.281047239297755 no 980 0.268959764226329 1341 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_3106 9121286 49.47 µM 0.615604067863729 0.281160275141671 no 981 0.269077932922672 1343 15943471
SGTC_1116 jasmonic acid 1.58368 µM 0.615470351787623 0.281202495852661 no 982 0.26912207163178 1370 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1094 duloxetine 25.4 µM 0.615097093931213 0.281320367828648 no 983 0.269245300570809 1318 60834 A selective serotonin reuptake inhibitor.
SGTC_682 0kpi-0099 17 µM 0.614814932047429 0.281409488219662 no 984 0.269338473477434 1317 1714895 YML126C ERG13
SGTC_10 0279-0212 42.575 µM 0.614521972056156 0.281502033590086 no 985 0.269435229140457 1318 39851 YBR002C RER2
SGTC_3209 9113616 49.47 µM 0.614086049692666 0.281639767609005 no 986 0.269579233117144 1340 16649353
SGTC_1367 1812-0510 76.9 µM 0.613778140988425 0.281737074014512 no 987 0.269680971890201 1322 1142582 YDR527W RBA50
SGTC_1706 st031321 9.9705 µM 0.612661611850328 0.28209005939867 no 988 0.27005005516466 1354 6103185
SGTC_666 0272-0154 136 µM 0.611344300989357 0.282506794596573 no 989 0.270485834203534 1337 6870312
SGTC_2820 7989630 71.43 µM 0.610722650003699 0.282703558486853 no 990 0.270691604261435 1234 2984098
SGTC_146 3448-8650 53.125 µM 0.608906215558007 0.283278870189933 no 991 0.271293302059073 1343 2891488 YIL048W NEO1
SGTC_2973 9094665 17.96 µM 0.607966365040637 0.283576765391163 no 992 0.271604891031273 1394 25237061 YIL048W NEO1
SGTC_1130 3454-2858 15.9 µM 0.606747187296083 0.283963419696484 no 993 0.272009350783526 1329 715628 YIL048W NEO1
SGTC_535 2293-4129 48.2 µM 0.606434496006741 0.284062628341671 no 994 0.272113133728169 1358 396118 YIL048W NEO1
SGTC_2900 5328528 85.29 µM 0.606385675488206 0.284078119292467 no 995 0.272129339144973 1317 795359
SGTC_3194 9111903 49.47 µM 0.60547620750352 0.284366771068096 no 996 0.272431314403432 1376 17087251
SGTC_547 1120-0019 610 nM 0.604682547258441 0.284618781637693 no 997 0.272694973347769 1343 3676939
SGTC_1166 k206-0078 225 µM 0.601630075310598 0.285589024106803 no 998 0.273710202333692 1328 5404595
SGTC_1267 0828-0272 9.49 µM 0.601440908442791 0.285649203439861 no 999 0.273773179266651 1408 745334
SGTC_406 estrone 100 µM 0.601192099349784 0.285728365838552 no 1000 0.273856023041535 1413 5870 A steroid.
SGTC_509 pifithrin 175 µM 0.597380949357412 0.28694224348176 no 1001 0.275126534939693 1427 4817 A p53 inhibitor.
SGTC_505 gw-5074 63.9 µM 0.595798379429634 0.287447019847464 no 1002 0.275654963238551 1400 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3164 9100705 49.47 µM 0.595728410043091 0.287469346967748 no 1003 0.275678337892406 1386 17174235
SGTC_2318 6029776 164 µM 0.595606435727854 0.287508270739189 no 1004 0.275719088148279 1423 818325
SGTC_593 1203-0218 61.7 µM 0.591700807411496 0.288755928754352 no 1005 0.277025477895899 1399 3666956
SGTC_431 k089-0097 107 µM 0.590844499781274 0.289029817685128 no 1006 0.277312307826599 1303 5499420
SGTC_2513 baicalein 25.65 µM 0.589481508831744 0.289466020526516 no 1007 0.277769156416142 1301 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2757 clomiphene 4.22 µM 0.589457122153264 0.28947382789682 no 1008 0.277777333711451 1428 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1521 st012942 49.4 µM 0.589162519975349 0.289568152297684 no 1009 0.277876128447909 1457 24207259
SGTC_2635 hydroquinidine 100 µM 0.587456257675366 0.290114739315339 no 1010 0.278448660022867 1375 442912 An experimental heart treatment.
SGTC_3202 9113761 49.47 µM 0.586712998478111 0.290352987343355 no 1011 0.278698238176618 1470 4798415
SGTC_2989 9073649 71.4286 µM 0.58586877434671 0.290623710253925 no 1012 0.278981851270385 1347 21367202
SGTC_779 1360-0071 233 µM 0.585357452753939 0.290787736514774 no 1013 0.27915369557009 1492 7566
SGTC_664 1222-0054 14.9 µM 0.585306313606992 0.290804143763113 no 1014 0.279170885178671 1352 6813991
SGTC_2955 9076254 12.21 µM 0.583691301671333 0.291322519275551 no 1015 0.279714010231513 1309 16459619
SGTC_3278 9139605 49.47 µM 0.583375791159393 0.291423840017641 no 1016 0.279820175579342 1394 7958859
SGTC_180 1486-1293 102.781 µM 0.583108881242938 0.291509566353489 no 1017 0.279910002692984 1459 4140536
SGTC_2619 obliquin 87.91 µM 0.582063701158267 0.291845371257052 no 1018 0.280261887026194 1369 6708593 A bioactive alkalod. YER133W GLC7
SGTC_206 4546-0025 72.014 µM 0.580691573857283 0.292286494084547 no 1019 0.280724170843262 1376 6620745 YIL048W NEO1
SGTC_2091 4-phenylthiadiazole 200 µM 0.580330118568522 0.292402749305502 no 1020 0.28084601019565 1378 270010
SGTC_1579 chlormadinone acetate 49.4 µM 0.576934460995717 0.293495946150272 no 1021 0.281991865002513 1422 45114258 A steroidal progestin.
SGTC_1921 5740136 50 µM 0.575554236875657 0.293940835477125 no 1022 0.282458260420019 1458 1774243
SGTC_2201 6605497 169.863 µM 0.575248648806237 0.294039378202967 no 1023 0.282561572681891 1405 670741
SGTC_2661 dactinomycin 12.96 µM 0.575000427971967 0.294119433003626 no 1024 0.282645503776376 1372 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2341 7987486 176.74 µM 0.574840942136245 0.294170874801297 no 1025 0.282699437161869 1414 1258686
SGTC_1319 1306-0155 43.7 µM 0.574509301931919 0.294277857911484 no 1026 0.28281160388627 1407 3122360
SGTC_997 3996-0078 137 µM 0.572678193497419 0.294868874566031 no 1027 0.283431302494278 1392 735687
SGTC_1872 amphotericin b 148 nM 0.571830468546667 0.295142675162653 no 1028 0.283718416729765 1374 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1575 cyproterone acetate 48 µM 0.571647337826099 0.295201838612437 no 1029 0.283780459190241 1319 9880 An androgen receptor antagonist and liver toxin.
SGTC_981 1488-1094 54.9 µM 0.571553229811017 0.295232243908212 no 1030 0.283812344367641 1341 3449522
SGTC_2993 9054257 71.4286 µM 0.571498878451567 0.295249804909339 no 1031 0.283830760187636 1371 6470217 YGL055W OLE1
SGTC_1178 0988-0033 191 µM 0.571281896832694 0.295319916768029 no 1032 0.283904285565393 1394 5392207
SGTC_1938 st074717 56.4 µM 0.569581860493322 0.295869503422486 no 1033 0.284480667214983 1303 17250979
SGTC_2742 clothiapine 36.27 µM 0.568800600386059 0.296122226124939 no 1034 0.284745733588165 1396 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_718 1130-0073 349 µM 0.568607545255603 0.296184691026547 no 1035 0.284811251600523 1455 6740020
SGTC_954 1189-0853 2.85 µM 0.567836787754166 0.296434137479181 no 1036 0.28507289880123 1365 2828194
SGTC_2093 5331342 194.4 µM 0.567006282701907 0.296703028237754 no 1037 0.285354956557778 1406 33839
SGTC_2629 bisabolol 100 µM 0.563936833792182 0.297697784627113 no 1038 0.286398560649884 1436 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_687 k029-0044 34.9 µM 0.562563054122597 0.298143495744388 no 1039 0.286866228006353 1445 5829338
SGTC_787 4152-0075 138 µM 0.56133109458622 0.298543452865707 no 1040 0.287285923933479 1433 9566539
SGTC_2869 9037858 32.47 µM 0.561309535255626 0.298550454300319 no 1041 0.287293271211563 1337 27187042
SGTC_1671 st016596 74.5 µM 0.560248771843876 0.298895031483856 no 1042 0.287654882169749 1391 2829167
SGTC_2839 9003951 25.97 µM 0.559826639174975 0.299032206819191 no 1043 0.287798845698051 1403 2990634
SGTC_635 k038-0028 24.7 µM 0.558275136906189 0.29953662513104 no 1044 0.288328260048451 1461 4035102
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.557996983620335 0.29962709798422 no 1045 0.288423221960309 1421 368090
SGTC_1996 st072960 66.8 µM 0.556608519292193 0.300078898500664 no 1046 0.288897465908773 1383 1719405
SGTC_891 0929-0073 133 µM 0.555614012466641 0.300402696170563 no 1047 0.289237375111072 1464 5603632
SGTC_692 k241-0027 77.8 µM 0.555285122112163 0.300509813045497 no 1048 0.289349826809139 1481 3600480
SGTC_1423 4048-0112 5.59 µM 0.553391850891017 0.301126771032217 no 1049 0.289997558919738 1446 X1423
SGTC_955 1216-0110 33 µM 0.552649954178664 0.301368687559894 no 1050 0.290251564293503 1359 3619719
SGTC_301 4119-0100 24.5 µM 0.551062345189112 0.3018866663471 no 1051 0.290795468517231 1410 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_26 0302-0163 425.158 µM 0.548815279154045 0.302620484816372 no 1052 0.2915661118255 1419 3100915
SGTC_3183 9108214 49.47 µM 0.54824657037982 0.302806333225993 no 1053 0.291761304442872 1357 4974831
SGTC_369 0957-0393 4.5 µM 0.547922021404416 0.302912415526317 no 1054 0.291872723648665 1372 6997992
SGTC_2906 7926292 26.41 µM 0.547631583225727 0.303007362450615 no 1055 0.291972449256749 1392 2966319
SGTC_520 3584-0023 682 µM 0.547180247418204 0.303154934716772 no 1056 0.292127452569539 1383 1340790
SGTC_3019 9081971 49.47 µM 0.544401794724252 0.30406410629099 no 1057 0.293082505523808 1506 16451803
SGTC_1320 1313-0481 95.3 µM 0.544328004991959 0.304088268492814 no 1058 0.293107889407888 1432 6813365 YLR208W SEC13
SGTC_1732 st034308 51.822 µM 0.543421806171178 0.304385070027639 no 1059 0.293419707574063 1389 830119
SGTC_2412 st077135 33.4 µM 0.543046028281907 0.304508183983811 no 1060 0.293549055796602 1500 13258915
SGTC_2135 5326629 150.42 µM 0.542702979500912 0.304620594432269 no 1061 0.293667161233147 1392 5020077
SGTC_2252 omeprazole 400 µM 0.541839359658657 0.304903667628951 no 1062 0.293964587130302 1421 4594 A proton pump inhibitor.
SGTC_2080 5212524 12.4 µM 0.541729206302081 0.304939781573983 no 1063 0.294002533350804 1455 260183
SGTC_727 3032-0951 202 µM 0.541027370626117 0.305169924073615 no 1064 0.294244358640851 1431 3652836
SGTC_401 neomycin 50 µM 0.540067432267442 0.305484827101654 no 1065 0.294575264779359 1416 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1714 st033236 13.627 µM 0.538988696128647 0.305838872947697 no 1066 0.294947327170893 1525 2916566
SGTC_2163 5671233 125 µM 0.537642113874617 0.306281081770424 no 1067 0.295412074868795 1543 701023
SGTC_467 ro 31-8220 72.8 µM 0.537353647494714 0.306375848988691 no 1068 0.295511677444374 1417 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.535937302210353 0.306841335769696 no 1069 0.29600094148976 1376 390807
SGTC_3270 9137563 49.47 µM 0.533508851902021 0.307640179317104 no 1070 0.296840692562936 1465 17015724
SGTC_229 benomyl 22.8748 µM 0.532636733130376 0.307927287525847 no 1071 0.297142534581661 1414 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2274 7947094 46.08 µM 0.532442771018756 0.307991157339212 no 1072 0.29720968431897 1410 2971028
SGTC_3124 9127567 49.47 µM 0.531412595981877 0.308330481281767 no 1073 0.297566447395523 1529 17592030
SGTC_1793 st048256 72.231 µM 0.531242297528032 0.30838659078204 no 1074 0.297625442799768 1380 672022
SGTC_1626 st003712 1.76 µM 0.528406546876774 0.309321563712566 no 1075 0.298608597248632 1462 24207035
SGTC_1283 0922-0125 16.4 µM 0.528244269270919 0.309375105567035 no 1076 0.298664903529108 1520 3360884
SGTC_1526 st051518 75 µM 0.527912681435148 0.30948452220279 no 1077 0.298779971242199 1446 673993
SGTC_169 k015-0017 16.025 µM 0.526950402366938 0.309802148572577 no 1078 0.299114015643958 1521 1840002
SGTC_1453 4237-0541 195 µM 0.526055060706129 0.310097808015246 no 1079 0.299424975638455 1452 739892
SGTC_1151 3909-8316 15.3 µM 0.523706489010591 0.310873935877201 no 1080 0.300241350811023 1452 800431
SGTC_3167 9103034 49.47 µM 0.522046964845061 0.311422863589438 no 1081 0.300818815641321 1457 5127859
SGTC_3238 9133470 49.47 µM 0.521511686609387 0.31160000933428 no 1082 0.301005183285437 1525 3534688
SGTC_1335 1486-0900 202 µM 0.520065900578948 0.312078697734294 no 1083 0.301508822082129 1426 X1335
SGTC_866 0495-0101 262 µM 0.519011000669291 0.312428167208326 no 1084 0.301876534993348 1396 635694
SGTC_2370 9071495 200 µM 0.518666082580998 0.312542469030417 no 1085 0.301996808901624 1418 21791103
SGTC_1937 st074714 47.2 µM 0.517203936974846 0.313027207154671 no 1086 0.302506902019742 1407 17250970
SGTC_2038 4100038 30.985 µM 0.516682502725003 0.313200154019075 no 1087 0.302688906171703 1487 3596803
SGTC_749 1000-0129 128 µM 0.516378151158474 0.313301118915138 no 1088 0.302795161311023 1571 708470
SGTC_1346 1488-2224 62.4 µM 0.515845682069332 0.313477792656547 no 1089 0.302981096943195 1491 3722427
SGTC_1265 0819-1001 68.8 µM 0.51478520855688 0.313829786241823 no 1090 0.303351561295688 1412 3106768
SGTC_2034 5197015 53.07 µM 0.514531048646172 0.313914172483448 no 1091 0.30344037923144 1547 780676
SGTC_625 k213-0058 121 µM 0.512032655686431 0.314744207116216 no 1092 0.304314077541799 1532 3655420
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.511456162886297 0.314935867011846 no 1093 0.304515838402275 1479 7104
SGTC_1059 3448-6867 171 µM 0.510605527617751 0.315218758914818 no 1094 0.304813652252373 1474 3934407
SGTC_2691 st077356 60.2 µM 0.509895309737247 0.315455035882797 no 1095 0.30506240402528 1559 2839272
SGTC_2966 9084041 48.03 µM 0.50961765945596 0.315547425763155 no 1096 0.305159674740366 1340 17741380
SGTC_2479 5617353 43.85 µM 0.508481624123426 0.315925568738993 no 1097 0.30555781141878 1530 2731746
SGTC_105 0111-0055 734.78 µM 0.507785402599975 0.316157409682524 no 1098 0.305801923997877 1456 5179370
SGTC_2773 thioridazine 9.09 µM 0.507478959052734 0.316259477942542 no 1099 0.30590939808856 1469 5452 An antipsychotic.
SGTC_3272 9137413 49.47 µM 0.503368962161576 0.317629760069865 no 1100 0.307352444618968 1398 17614870
SGTC_1011 4112-3381 17.4 µM 0.503327219462232 0.317643690044935 no 1101 0.307367116112367 1515 2877139
SGTC_1854 st056233 32.9 µM 0.502324114608542 0.317978514224983 no 1102 0.307719774529753 1523 5393174
SGTC_512 prima-1 270 µM 0.502186763978615 0.318024371783567 no 1103 0.307768076299556 1545 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_3335 9143315 29.6265 µM 0.499202815824548 0.319021316921157 no 1104 0.308818255545514 1472 4899691
SGTC_1455 4262-0120 131 µM 0.498572940224595 0.319231927824537 no 1105 0.309040136109371 1555 1529587
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.497640971391735 0.31954365638198 no 1106 0.309368560137729 1462 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3351 9150312 21.596 µM 0.493796727756255 0.320830840208531 no 1107 0.310724872180738 1477 4904905
SGTC_1682 st012968 530 nM 0.492063732470652 0.321411812394275 no 1108 0.311337144919939 1433 24207270
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.48773312591237 0.322865520911285 no 1109 0.312869442434241 1521 688664
SGTC_1932 st074806 40.9 µM 0.487676729249155 0.322884470206914 no 1110 0.312889418671146 1574 17251235
SGTC_1026 k007-1105 30.6 µM 0.487051747265257 0.323094495113061 no 1111 0.313110830030875 1482 7066794
SGTC_2754 granisetron 64.02 µM 0.486232036965588 0.323370043887577 no 1112 0.313401329649828 1599 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_176 1486-1328 72.834 µM 0.485790436592287 0.323518529731472 no 1113 0.313557877754329 1485 22310231
SGTC_1195 1502-0147 41.1 µM 0.485471998691435 0.323625620273404 no 1114 0.313670785390563 1469 817940
SGTC_257 daunorubicin 18.5 µM 0.48158947390989 0.324932484407656 no 1115 0.315048802595548 1642 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.48060494472492 0.325264222042317 no 1116 0.315398650225063 1589 688798
SGTC_2461 5755302 26.15 µM 0.480382681310065 0.325339132994154 no 1117 0.315477653360828 1614 2788904
SGTC_1692 fluoroquinolonic acid 71 µM 0.479087392880499 0.325775833205035 no 1118 0.31593822906369 1548 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1623 st003709 20.3 µM 0.477425921564954 0.326336340307083 no 1119 0.316529429723951 1483 16192618
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.477183350596927 0.32641820590525 no 1120 0.316615782929471 1497 689007
SGTC_1226 3909-7979 35.4 µM 0.476569993886894 0.326625245772835 no 1121 0.316834177296122 1594 6615510
SGTC_2199 6590217 200 µM 0.476064909985317 0.326795778025163 no 1122 0.317014067530933 1542 703109
SGTC_1004 4084-0029 199 µM 0.475128794010695 0.327111935962535 no 1123 0.317347588129757 1609 716894 YLR208W SEC13
SGTC_1828 st055811 49 µM 0.47292401190237 0.327857055289305 no 1124 0.318133696580005 1562 5877589
SGTC_2262 9014885 67.46 µM 0.472692677497305 0.327935275942981 no 1125 0.31821622575807 1514 6457424
SGTC_1087 pterostilbene 9.05 µM 0.471792535696788 0.328239710947373 no 1126 0.318537439642494 1624 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3178 9107506 49.47 µM 0.471101244927864 0.328473588378213 no 1127 0.318784218074038 1540 8897194
SGTC_2884 9058502 51.95 µM 0.470852535241327 0.328557748265056 no 1128 0.318873022647181 1490 6471554
SGTC_1253 0550-0034 176 µM 0.469798376458672 0.328914557403525 no 1129 0.319249537229956 1512 5969915
SGTC_910 3454-3003 490 µM 0.468940073617578 0.329205188906728 no 1130 0.31955623558479 1512 820824
SGTC_1485 3909-9022 254 µM 0.468840055982141 0.329239062782113 no 1131 0.319591983038612 1516 714516
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.468761633362217 0.329265623859193 no 1132 0.319620013357893 1579 756377
SGTC_2821 7996764 71.43 µM 0.467928606020051 0.329547816333551 no 1133 0.319917822951306 1580 2987135
SGTC_2025 5147754 141 µM 0.46603584398058 0.33018936033126 no 1134 0.3205949220143 1586 315777 YLR208W SEC13
SGTC_2864 9034755 47.6 µM 0.46098672764412 0.331903177491156 no 1135 0.322404063692446 1514 4930451
SGTC_306 1672-3436 11.6 µM 0.4608794365693 0.331939633559372 no 1136 0.322442552876949 1577 6797378
SGTC_2736 butenafine 14.65 µM 0.460097695894975 0.33220530656892 no 1137 0.322723048930059 1596 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1635 st007035 42.4 µM 0.459961187985776 0.332251707164146 no 1138 0.322772039629768 1557 3716403
SGTC_1482 3346-2049 8.48 µM 0.459555324371858 0.332389680022118 no 1139 0.322917716333906 1577 3826804
SGTC_972 1319-0219 195 µM 0.459529020731603 0.332398622697659 no 1140 0.322927158442327 1498 23903702
SGTC_1975 st070967 30.8 µM 0.459214768874087 0.33250546899085 no 1141 0.323039972950922 1623 261391
SGTC_1865 st057639 52.2 µM 0.459182495120654 0.332516442905768 no 1142 0.323051559954486 1532 688818
SGTC_2399 5884133 200 µM 0.458874155968415 0.332621293466535 no 1143 0.323162269302712 1513 722445
SGTC_3137 9097352 49.47 µM 0.458313669017488 0.332811920280911 no 1144 0.3233635525747 1610 44120435
SGTC_1452 4194-0072 190 µM 0.457886408070191 0.332957264733104 no 1145 0.323517026177344 1674 1343545
SGTC_2981 9013952 38.96 µM 0.457170985380545 0.333200691446454 no 1146 0.323774075693993 1438 2996344
SGTC_1223 0764-0573 147 µM 0.456055615204085 0.333580342785482 no 1147 0.324174993004722 1524 1609797
SGTC_2687 chenodiol 100 µM 0.455047424436111 0.333923658963036 no 1148 0.324537560454121 1583 5702181 A cholesterol synthesis inhibitor.
SGTC_13 0199-0087 65 µM 0.453194494016022 0.334554994262275 no 1149 0.325204348422004 1574 4589825
SGTC_1689 st020265 53.493 µM 0.451110681265013 0.335265555615499 no 1150 0.325954889879719 1639 5758320 YPR016C TIF6
SGTC_2456 5770359 74.46 µM 0.450260674748044 0.335555569683182 no 1151 0.32626124552578 1634 3118787
SGTC_1822 st052468 42 µM 0.449870904691986 0.335688588267967 no 1152 0.326401763978973 1521 2873678
SGTC_234 nsc-17383 10.7 µM 0.449667546015088 0.335757997576171 no 1153 0.32647508787718 1628 408974
SGTC_1089 terbinafine 2.25 µM 0.448742424994692 0.336073825686574 no 1154 0.326808738177897 1608 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.445589956573069 0.337150918664282 no 1155 0.327946733364839 1601 688662
SGTC_784 4579-0127 173 µM 0.445180105418684 0.3372910494346 no 1156 0.328094801361324 1698 1948547
SGTC_1287 0971-0001 34.6 µM 0.443190852858623 0.337971508171813 no 1157 0.328813847275247 1586 4665869
SGTC_1201 1889-3372 45.9 µM 0.439930959581472 0.33908775657317 no 1158 0.329993555984175 1568 5392199
SGTC_351 caspofungin 25 nM 0.438843558550375 0.339460418015352 no 1159 0.330387447920447 1650 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3297 9117502 71.43 µM 0.438821990569767 0.339467811132438 no 1160 0.330395262445595 1568 7453720
SGTC_2986 9022445 71.43 µM 0.438799874910523 0.339475392048097 no 1161 0.330403275482834 1676 6459286
SGTC_2602 kawain 100 µM 0.438280391760912 0.339653481742738 no 1162 0.330591519127808 1553 5369129
SGTC_825 1988-2224 89.6 µM 0.435787200128512 0.34050869768164 no 1163 0.331495565753925 1570 1180859
SGTC_2125 5246583 200 µM 0.435170324839787 0.340720425403489 no 1164 0.331719400369513 1723 835267
SGTC_2208 7283366 200 µM 0.431729028527951 0.341902487632949 no 1165 0.332969183436936 1660 898663
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.431037783745661 0.342140113078685 no 1166 0.333220448807438 1760 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1887 st057648 70.8 µM 0.428684622034415 0.342949514900411 no 1167 0.334076376639079 1702 688672
SGTC_1075 aripiprazole 15.2 µM 0.426985123661284 0.343534529189698 no 1168 0.334695081550711 1574 60795 An atypical antipschotic. YIL048W NEO1
SGTC_399 oxolinic acid 75 µM 0.425096692371217 0.344185019241076 no 1169 0.335383094511201 1566 4628 A DNA gyrase inhibitor.
SGTC_2910 7948405 25.97 µM 0.425060397843306 0.344197525797624 no 1170 0.335396323129896 1684 2971328
SGTC_529 4076-0302 30.3 µM 0.423727936255914 0.344656790180563 no 1171 0.335882119492828 1573 5816522
SGTC_390 dec-rvkr-cmk 16.7 µM 0.423082482207318 0.344879343569859 no 1172 0.336117541454924 1616 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_790 1575-0012 79.1 µM 0.422741238839051 0.344997026421367 no 1173 0.336242032047895 1632 378741 YLR208W SEC13
SGTC_2247 cerulenin 830 nM 0.421394370509048 0.345461660292064 no 1174 0.336733564620824 1670 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2798 7813637 45.45 µM 0.420105984980822 0.34590633717403 no 1175 0.337204015352571 1647 956368
SGTC_1005 4092-0690 4.4 µM 0.419867242652071 0.345988760718113 no 1176 0.337291219503738 1562 1529343
SGTC_3349 9149703 23.001 µM 0.419846245782512 0.345996010039083 no 1177 0.337298889337811 1552 4910494
SGTC_405 ebelactone b 50 µM 0.419788657093515 0.346015893239892 no 1178 0.337319925948738 1572 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3025 9087895 49.47 µM 0.419630476229496 0.346070509306722 no 1179 0.337377710559653 1680 17173641
SGTC_404 fumagillin 50 µM 0.418582833002996 0.346432316228618 no 1180 0.337760518962105 1612 12015870 A methionine aminopeptidase binder.
SGTC_465 cgp-37157 41 µM 0.416959414097685 0.34699324589855 no 1181 0.33835404712199 1676 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1368 1852-0141 284 µM 0.41666834957806 0.347093851080165 no 1182 0.338460503948423 1601 2838987
SGTC_2700 st077718 96.8 µM 0.411492447913321 0.348884672950847 no 1183 0.34035573889334 1582 904970
SGTC_913 3487-1245 167 µM 0.410192154305584 0.349335095923802 no 1184 0.340832497873307 1519 4016153
SGTC_3153 9100258 49.47 µM 0.409409799375381 0.349606206758579 no 1185 0.341119474719661 1562 25236848
SGTC_2094 5332512 191.667 µM 0.407615258464605 0.350228361824843 no 1186 0.341778080153211 1715 755774
SGTC_1968 st069590 43.6 µM 0.406241166496181 0.350705022079529 no 1187 0.342282704619454 1688 6384066
SGTC_2808 7946468 45.46 µM 0.404463337148816 0.351322084049958 no 1188 0.342936016458809 1660 2970879
SGTC_175 3793-3120 23.7 µM 0.404266603540705 0.351390391910091 no 1189 0.343008340494759 1605 5322297
SGTC_2915 7971052 15.16 µM 0.403478241779075 0.351664167071479 no 1190 0.343298219047352 1570 5741558
SGTC_1736 st036774 51 µM 0.401894195186643 0.352214493003685 no 1191 0.343880947481549 1817 1272247
SGTC_1362 1611-0397 101 µM 0.401364275600025 0.352398665655193 no 1192 0.344075973642306 1610 27816
SGTC_2588 indole-3-carbinol 100 µM 0.398851546784206 0.353272430825513 no 1193 0.345001296484057 1761 3712 Induces cell cycle arrest.
SGTC_1728 st035614 33.7865 µM 0.397669988487107 0.353683568512488 no 1194 0.345436731268046 1661 15945546
SGTC_2176 5809774 33.9695 µM 0.396459925455473 0.354104801734969 no 1195 0.345882882890485 1754 2870539
SGTC_3118 9124250 49.47 µM 0.394850945327241 0.354665177950507 no 1196 0.346476447197627 1598 1504786
SGTC_589 1227-0070 34.1 µM 0.393576402174663 0.3551092997576 no 1197 0.346946903124191 1654 2841384
SGTC_347 4534-1311 26.2 µM 0.392858499224689 0.355359543854988 no 1198 0.347211997489901 1613 2862016
SGTC_2462 5162487 171.77 µM 0.392601080923541 0.355449289024278 no 1199 0.347307070537015 1694 2259986
SGTC_153 4077-0274 519.67 µM 0.392457114157593 0.355499484451348 no 1200 0.347360246389932 1757 3121976
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.389733222652727 0.356449667427502 no 1201 0.348366913564953 1680 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3188 9110789 49.47 µM 0.387133686124674 0.357357303131562 no 1202 0.349328620153994 1728 849217
SGTC_2137 5261020 140 µM 0.387058587077215 0.357383536207505 no 1203 0.349356417696901 1633 763655
SGTC_1374 2889-5571 141 µM 0.384257086717895 0.358362617339806 no 1204 0.350393955408633 1635 2853281
SGTC_2730 imipramine 71.33 µM 0.382382326396785 0.3590183380599 no 1205 0.351088898837294 1718 3696 A tricyclic antidepressant.
SGTC_2804 7954240 19.48 µM 0.380744191012835 0.359591636592845 no 1206 0.35169653727123 1765 828705
SGTC_2030 5175110 200 µM 0.380018436853526 0.359845730042521 no 1207 0.351965864690099 1713 2831986
SGTC_93 0109-0045 59.227 µM 0.379578849497766 0.359999663901272 no 1208 0.35212903172242 1675 88733
SGTC_2794 7785382 27.27 µM 0.378161359745875 0.360496192300078 no 1209 0.352655364106926 1798 2205081
SGTC_2040 5100729 123 µM 0.37799624328519 0.360554045787627 no 1210 0.352716692365385 1697 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_3247 9135149 49.47 µM 0.377927568178046 0.360578109104221 no 1211 0.352742201093118 1659 8934436 YOR116C RPO31
SGTC_928 2764-0428 58.7 µM 0.376854412276521 0.3609542077119 no 1212 0.353140900781563 1702 662578
SGTC_1251 0490-5699 265 µM 0.376573554876762 0.361052659316714 no 1213 0.353245271777235 1796 3883818
SGTC_1443 4112-3303 14 µM 0.37614103237023 0.361204293530786 no 1214 0.353406025483208 1657 704433
SGTC_1205 4161-2785 76 µM 0.375545372184086 0.361413156429018 no 1215 0.353627454648925 1578 3498106
SGTC_14 0354-0009 295 µM 0.374949952655665 0.361621976227961 no 1216 0.353848843861833 1708 1713507
SGTC_628 1636-0253 16 µM 0.372754051230799 0.362392457506669 no 1217 0.354665751915739 1756 4456143
SGTC_2290 7904846 200 µM 0.372637618172274 0.362433326254582 no 1218 0.354709085453383 1641 2962154
SGTC_479 n-linoleoylglycine 10 µM 0.37219209742553 0.362589721357994 no 1219 0.354874914739435 1661 6433346 An anti-infammatory.
SGTC_1947 st076332 61.6 µM 0.371696209087176 0.362763824409035 no 1220 0.355059523911776 1753 24208416
SGTC_265 mycophenolic acid 32.932 µM 0.37112224039989 0.36296537637106 no 1221 0.355273243301569 1749 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3267 9137951 49.47 µM 0.369040105631984 0.36369684663862 no 1222 0.356048915689618 1706 16643986
SGTC_1271 0832-2808 169 µM 0.368970644316188 0.363721257526232 no 1223 0.356074802898304 1799 3663794
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.36879146949205 0.363784227739636 no 1224 0.356141581777372 1725 5377381
SGTC_613 3914-0030 117 µM 0.36755115729476 0.364220230877457 no 1225 0.356603969956241 1681 1145395
SGTC_2521 angolensin 13.4 µM 0.367464565834385 0.364250676678435 no 1226 0.356636259118917 1712 821428 A flavenoid.
SGTC_731 3966-0296 387 µM 0.365881973038912 0.364807271479003 no 1227 0.357226574255461 1677 660956
SGTC_3023 9089636 49.47 µM 0.365200895341331 0.365046892979845 no 1228 0.357480724999894 1748 17249241
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.365123047670295 0.365074285248264 no 1229 0.357509778641027 1699 4213774
SGTC_1414 3917-0015 5.4 µM 0.36442426600978 0.365320196440037 no 1230 0.357770608906642 1726 6618702
SGTC_1174 0739-0097 51.1 µM 0.364337334795559 0.365350792644556 no 1231 0.357803061876093 1689 728447
SGTC_139 0099-0334 718.624 µM 0.361383381655527 0.366390970548246 no 1232 0.358906434655778 1741 97690
SGTC_270 tamoxifen 5.46 µM 0.361017559899146 0.366519856171889 no 1233 0.35904316008961 1819 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_94 0334-0113 514.748 µM 0.360734307074969 0.366619661608758 no 1234 0.35914903789128 1626 6795178
SGTC_1956 st077085 54 µM 0.360361515640585 0.366751030133176 no 1235 0.359288401048735 1655 24208685
SGTC_3072 9116419 49.47 µM 0.360179674467133 0.366815115077709 no 1236 0.359356386766314 1643 17170162
SGTC_2745 rifampicin 24.3 µM 0.358736312220708 0.36732392013696 no 1237 0.359896180413136 1812 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2227 7312221 64.1025 µM 0.358726961367827 0.367327217202043 no 1238 0.359899678390234 1744 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_773 4358-1457 44.6 µM 0.356692685122871 0.368044725231278 no 1239 0.360660941118148 1839 1186886
SGTC_2109 5483026 200 µM 0.356143284123954 0.368238583139582 no 1240 0.360866631730447 1707 759335
SGTC_1881 5652484 16 µM 0.355471673904845 0.368475608538483 no 1241 0.361118131006362 1806 2255129
SGTC_702 1488-0190 94 µM 0.354755242715969 0.368728507380464 no 1242 0.361386480676331 1835 949357
SGTC_2623 humulene 100 µM 0.353902292157577 0.369029671437304 no 1243 0.361706054589236 1656 6187145 An anti-inflammatory.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.352074587255486 0.36967527723324 no 1244 0.362391163097905 1923 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_3320 9137005 35.139 µM 0.351506079297194 0.369876168072813 no 1245 0.362604356244756 1699 4908713
SGTC_902 1120-0002 2.07 µM 0.351387739120787 0.369917989822052 no 1246 0.362648739724804 1655 3280475
SGTC_61 0978-8327 98.565 µM 0.350013836529398 0.370403643333764 no 1247 0.363164156812861 1723 6150059 YHR072W ERG7
SGTC_1712 st032288 53.4 µM 0.349181857735471 0.370697835591712 no 1248 0.363476392736181 1690 2883011
SGTC_92 0063-0024 660.874 µM 0.348911682518743 0.370793387301169 no 1249 0.363577807161201 1762 3594437
SGTC_1331 1472-0049 76.2 µM 0.348583317101514 0.370909529616955 no 1250 0.363701077043744 1658 24051409
SGTC_2107 5363541 170.161 µM 0.347485870619412 0.371297779946075 no 1251 0.364113165804028 1718 244052
SGTC_316 k060-0003 58.6 µM 0.344378108345278 0.372397941529837 no 1252 0.36528097508363 1787 6152314
SGTC_60 0986-0278 202 µM 0.343163184221711 0.372828313876146 no 1253 0.365737849790097 1545 3110598
SGTC_2282 7944268 200 µM 0.343073079045312 0.372860238888953 no 1254 0.36577174162256 1776 2970414
SGTC_3265 9137266 49.47 µM 0.342965858324744 0.372898229219072 no 1255 0.365812072598492 1871 17224265
SGTC_864 0469-0573 172 µM 0.341769759010162 0.373322113570559 no 1256 0.366262084723101 1681 689425
SGTC_1246 0422-0085 105 µM 0.339109741787751 0.37426534327562 no 1257 0.36726352995813 1850 264295
SGTC_3041 9091929 49.47 µM 0.338176752018158 0.374596355792612 no 1258 0.367614997036361 1767 25236887
SGTC_970 1315-0089 19.5 µM 0.33802092842735 0.374651648970644 no 1259 0.367673708241229 1646 6811083 YLR033W RSC58
SGTC_102 gallobenzophenone 83.616 µM 0.337426116831909 0.374862738410764 no 1260 0.367897849746856 1807 70837
SGTC_1994 st072947 40.9 µM 0.335764795732291 0.375452514019051 no 1261 0.368524119705643 1778 5286565 YDL195W SEC31
SGTC_2828 7998861 71.43 µM 0.334202125763037 0.376007533905999 no 1262 0.369113520001929 1856 2988188
SGTC_2409 alverine citrate 63.97 µM 0.333733186677776 0.376174139023097 no 1263 0.369290452295782 1837 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2959 9079155 11 µM 0.333576280874673 0.376229889818 no 1264 0.369349659567668 1753 16189457
SGTC_3105 9121040 49.47 µM 0.332710648104531 0.376537507472949 no 1265 0.369676355517312 1810 41448907
SGTC_2608 thymoquinone 42.66 µM 0.331868287829123 0.376836930134481 no 1266 0.369994358606924 1735 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3180 9109287 49.47 µM 0.330790364205696 0.3772201934354 no 1267 0.370401419895897 1739 18891271
SGTC_462 ag-879 158 µM 0.325258199125632 0.379189089645521 no 1268 0.372492832277515 1837 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1513 0337-0559 19 µM 0.325016607784081 0.379275143824495 no 1269 0.372584251148817 1656 775073
SGTC_2999 9069765 71.4286 µM 0.323190965179258 0.379925625883723 no 1270 0.373275311408584 1797 2097066
SGTC_1943 st076331 65.2 µM 0.321991303914095 0.380353254035784 no 1271 0.373729641228523 1877 24208415
SGTC_2843 9000894 45.46 µM 0.321601862340248 0.380492104845838 no 1272 0.373877166396529 1726 2242070
SGTC_2701 st077767 14.721 µM 0.321477132728316 0.380536578977525 no 1273 0.373924419386504 1742 5721188
SGTC_1668 st014914 51.6 µM 0.320723691315749 0.380805262873778 no 1274 0.374209895959479 1759 2839556
SGTC_132 0417-1715 25.805 µM 0.316175549975288 0.382428387156146 no 1275 0.375934632424239 1903 6769098
SGTC_2154 5570129 200 µM 0.31597143540923 0.382501279519728 no 1276 0.376012094748019 1767 673366
SGTC_3139 9095020 49.47 µM 0.315374159345822 0.38271459963911 no 1277 0.376238792177862 1706 25236292
SGTC_706 4262-0057 46.9 µM 0.314903429355372 0.382882748277723 no 1278 0.376417488866119 1711 883298
SGTC_946 3434-1334 87.4 µM 0.314649425060889 0.382973489880086 no 1279 0.376513923994651 1817 4047976
SGTC_2985 9022375 71.43 µM 0.31418254364494 0.383140297383472 no 1280 0.376691200032056 1757 4939335
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.31262508293633 0.383696903875711 no 1281 0.377282759622926 1804 6708630 An antioxidant.
SGTC_1539 benzyladenosine 56 µM 0.312325193976073 0.383804106017499 no 1282 0.377396697502175 1757 92208 A nucleotide analog.
SGTC_863 0466-0191 129 µM 0.308694314050474 0.38510275017319 no 1283 0.378777034732937 1860 765160 YPR165W RHO1
SGTC_2048 5246248 200 µM 0.308613461468113 0.385131683167254 no 1284 0.378807789819 1880 677046
SGTC_385 1494-0393 12.4 µM 0.307003180876411 0.385708053032791 no 1285 0.379420475537938 1807 3090647
SGTC_3042 9091578 49.47 µM 0.306901912112842 0.385744308745703 no 1286 0.379459016805098 1810 25236497
SGTC_2336 9001819 198.65 µM 0.305937625283331 0.386089587633689 no 1287 0.379826068863208 1847 2989602
SGTC_2046 4110841 106 µM 0.305510211965292 0.386242658940221 no 1288 0.379988796750987 1894 44119630 YMR134W ERG29
SGTC_2358 9037157 4 µM 0.30499922854333 0.386425682793058 no 1289 0.380183369939366 1804 2388925
SGTC_3099 9120367 49.47 µM 0.304971309146265 0.386435683680819 no 1290 0.380194002011885 1763 24824940
SGTC_2413 inermin 26.06 µM 0.30066407140102 0.387979460591149 no 1291 0.381835334315319 1914 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1066 ketoconazole 628 nM 0.300619203001885 0.387995551448436 no 1292 0.381852443278883 1843 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1292 0kpi-0043 232 µM 0.299137775537038 0.388526933821204 no 1293 0.382417462208658 1767 3333905
SGTC_457 grayanotoxin iii 135 µM 0.296518648640718 0.389466914698739 no 1294 0.383417013710182 1838 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1556 plumbagin 1.48 µM 0.295621578489294 0.389789014080523 no 1295 0.38375954627942 1840 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_233 rapamycin 362 pM 0.294939319815731 0.390034034577604 no 1296 0.384020117194242 1865 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_3013 9080133 71.4286 µM 0.29490721812231 0.390045564380118 no 1297 0.384032378891784 1834 17050193
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.294360133665253 0.390242072795617 no 1298 0.38424136340398 1921 1273210
SGTC_1369 1866-0067 208 µM 0.293297778013545 0.390623742624594 no 1299 0.384647275949201 1891 3531355
SGTC_1816 st051957 91.6 µM 0.292317427135584 0.390976044335914 no 1300 0.385021967752593 1797 674121
SGTC_323 4013-0906 34.3 µM 0.288743175167759 0.392261253696697 no 1301 0.386388960108652 1921 2910086
SGTC_1773 st048542 73.5835 µM 0.288399057400578 0.392385051910781 no 1302 0.386520644589273 1726 3237138
SGTC_1787 fluconazole 80 µM 0.286670409789784 0.393007106705929 no 1303 0.387182348304047 1813 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1154 4088-0362 150 µM 0.285841985444033 0.393305312639574 no 1304 0.38749957468458 1779 6618304
SGTC_2677 mitomycin C 100 µM 0.284841879917016 0.393665401639179 no 1305 0.387882642569873 1816 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_845 0330-0138 4.51 µM 0.284777978268898 0.393688412586349 no 1306 0.387907122369489 1914 9039800
SGTC_1385 3091-4834 14.1 µM 0.284275531025484 0.393869356482889 no 1307 0.388099618175448 1873 4072814
SGTC_447 ml7 120 µM 0.284167352510163 0.393908317287868 no 1308 0.388141066743499 1892 4216 Selective myosin light chain kinase inhibitor.
SGTC_223 busulfan 5 mM 0.283132848654364 0.394280950420154 no 1309 0.388537500897979 1877 2478 A DNA alkylator.
SGTC_2185 6113692 200 µM 0.281580943961447 0.394840135154186 no 1310 0.389132426854901 1825 874150
SGTC_2194 5927483 104.545 µM 0.280918740877289 0.39507880723711 no 1311 0.389386363039974 1849 760979
SGTC_321 4534-3890 65.3 µM 0.280848152101218 0.395104251257803 no 1312 0.389413434630665 1919 699746
SGTC_1213 1315-0166 115 µM 0.280199457770169 0.395338096781959 no 1313 0.389662241325578 1698 768401
SGTC_1534 6-azauridine 81.6 µM 0.278736657854896 0.395865554560821 no 1314 0.39022346403615 1818 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3253 9135987 49.47 µM 0.278651467250205 0.395896278556682 no 1315 0.390256155612163 1853 4182430
SGTC_1984 st072354 53.1 µM 0.277224159763587 0.396411133128698 no 1316 0.390803994775497 1843 5762938
SGTC_100 0086-0128 49.5915 µM 0.276495770837462 0.396673945343271 no 1317 0.391083653738325 1720 93297
SGTC_1121 fusaric acid 630.51 nM 0.276251976631616 0.396761919960961 no 1318 0.391177269115516 1762 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_739 1486-1183 203 µM 0.275728927955647 0.396950682973711 no 1319 0.391378137646993 1956 4346692
SGTC_2240 6690706 185.951 µM 0.275411931731695 0.397065095480712 no 1320 0.391499889111903 1718 805876
SGTC_490 phenamil 164 µM 0.27520738615987 0.397138926210735 no 1321 0.391578456331329 1904 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1296 1068-0102 11.9 µM 0.274797241046639 0.397286979205037 no 1322 0.391736008928981 1900 767053
SGTC_948 3448-0295 75.3 µM 0.274503642740193 0.397392970561747 no 1323 0.391848802298823 1798 678569
SGTC_2975 9084847 53.72 µM 0.272549975326204 0.398098452855305 no 1324 0.39259958515649 1789 27211724
SGTC_3174 9107204 49.47 µM 0.272439302187952 0.398138427657355 no 1325 0.392642128183284 1902 3938802
SGTC_507 nimesulide 162 µM 0.272178735803147 0.398232547666877 no 1326 0.392742295607493 1954 4495 A COX2 inhibitor.
SGTC_1302 1159-0335 255 µM 0.271552208713006 0.39845888172846 no 1327 0.392983175406074 1785 649284
SGTC_3293 9120939 62.045 µM 0.27100081329219 0.398658102601412 no 1328 0.393195203371054 1881 934087
SGTC_1466 k213-0079 57.5 µM 0.269485854304386 0.399205597789264 no 1329 0.393777913172786 1833 3657981
SGTC_1024 4507-0395 26 µM 0.269224659411607 0.399300011802717 no 1330 0.393878402565948 1833 4201836
SGTC_971 1315-0384 26.7 µM 0.266291931861097 0.400360506789127 no 1331 0.395007193145856 1770 6769120
SGTC_2693 st077581 40.7 µM 0.264989958006199 0.400831545789526 no 1332 0.395508598862578 1932 25238761
SGTC_766 1391-0721 126 µM 0.264286838407169 0.401085986302126 no 1333 0.395779450636276 1935 1020919 YIL115C NUP159
SGTC_1959 st077091 55.8 µM 0.263787292445683 0.401266784364823 no 1334 0.395971913511665 1817 821356 YKL052C ASK1
SGTC_2448 5185112 27.17 µM 0.263309474014442 0.401439738480066 no 1335 0.396156029032671 1833 5718189
SGTC_947 3447-0010 211 µM 0.263219300020774 0.40147238058375 no 1336 0.396190777951709 1874 748350
SGTC_3048 9093155 49.47 µM 0.262715671668313 0.401654701758705 no 1337 0.396384868366827 1962 25236002
SGTC_3246 9135460 32.98 µM 0.26215835481338 0.401856483946353 no 1338 0.396599679415818 1911 41446951
SGTC_1427 4048-4900 550 nM 0.262088551602279 0.401881758747765 no 1339 0.396626586433347 1969 24132586
SGTC_1642 st009582 77.7 µM 0.262022615396159 0.401905633735717 no 1340 0.396652003290031 1968 6739311
SGTC_780 0109-0199 192 µM 0.260924141515947 0.402303436377475 no 1341 0.397075503652504 1977 610414
SGTC_522 1273-0010 11.6 µM 0.260689154412946 0.402388548041585 no 1342 0.397166115234604 1868 5705015
SGTC_992 3909-8734 162 µM 0.260497577708508 0.402457940006504 no 1343 0.397239991772123 1803 4288319
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.260204779067912 0.402564002017704 no 1344 0.397352909020447 1896 688801
SGTC_1666 st014829 29 µM 0.256723602408342 0.403825554654087 no 1345 0.398696074980242 1830 3858230
SGTC_1458 k015-0034 6.33 µM 0.255861963526189 0.404137961271268 no 1346 0.399028712941549 1774 3598957
SGTC_3120 9124077 49.47 µM 0.255541330974306 0.404254229458207 no 1347 0.399152512719405 1984 18774327 YGL155W CDC43
SGTC_2705 st078069 42.8 µM 0.255506004004004 0.404267040286891 no 1348 0.399166153474338 1849 1530061
SGTC_333 3486-0131 40.1 µM 0.251776212894797 0.405620171530209 no 1349 0.400607022249416 1985 6744690
SGTC_2823 7987624 58.44 µM 0.251428328855661 0.405746438201411 no 1350 0.400741483870617 1874 2239440
SGTC_277 nystatin 15.5 µM 0.251225780568208 0.405819958877568 no 1351 0.400819776787344 1805 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2829 7992743 58.44 µM 0.25105823366709 0.405880777313218 no 1352 0.400884543296166 2049 16462845
SGTC_936 3005-4620 401 µM 0.247264331082801 0.407258544673232 no 1353 0.40235183075032 1986 777207
SGTC_2739 tacrine 100.86 µM 0.246695368275873 0.407465264687393 no 1354 0.402571995691343 1879 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.245279967466194 0.407979630856887 no 1355 0.403119830857322 1932 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_788 1182-0090 188 µM 0.24471060532817 0.408186585676028 no 1356 0.403340257904213 1984 5715185
SGTC_1505 k297-0037 20.6 µM 0.243831953835737 0.408506012902837 no 1357 0.403680485755745 1835 4089396
SGTC_337 1315-0038 354 µM 0.243404861340973 0.4086613011797 no 1358 0.403845889116367 1876 1626437
SGTC_2673 kobusone 100 µM 0.242407383423991 0.409024034004016 no 1359 0.404232256908741 1923 6710676 An epoxy ketone and protein crosslinker.
SGTC_311 1315-0136 58 µM 0.24180830264797 0.409241927190911 no 1360 0.40446435260938 1970 6759207
SGTC_1052 3253-3998 198 µM 0.240084989623619 0.409868873877078 no 1361 0.405132185247995 1922 5450317
SGTC_1679 SEC14.276 6.7 µM 0.236749764455869 0.411082892660135 no 1362 0.406425462885779 2025 1005053 YMR079W SEC14
SGTC_3030 9087619 49.47 µM 0.228753812105657 0.413996860910827 no 1363 0.409530133747463 1870 25236973
SGTC_811 0416-0114 265 µM 0.228279102856597 0.414170010078985 no 1364 0.409714634599509 1880 6612453
SGTC_259 usnic acid 108.925 µM 0.228271654803034 0.414172726873378 no 1365 0.409717529525002 1971 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1318 1280-3875 124 µM 0.228014467866306 0.414266542362236 no 1366 0.409817496515523 1931 373245
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.227980444933689 0.414278953460371 no 1367 0.409830721460705 2011 77254
SGTC_1801 st050089 28.441 µM 0.226353849262898 0.414872412852877 no 1368 0.410463109675894 1917 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2886 9058944 51.95 µM 0.225546209282699 0.415167150577432 no 1369 0.410777190741499 1933 4949929
SGTC_491 tetrandrine 80.3 µM 0.225199251588525 0.415293782955062 no 1370 0.410912135821644 1987 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1407 3909-7909 12.3 µM 0.224782382456036 0.41544594319739 no 1371 0.411074286070525 1912 4411780
SGTC_1473 k844-0725 134 µM 0.223270084018668 0.415998049325234 no 1372 0.411662654549276 1993 54682906
SGTC_2378 9074213 121.43 µM 0.222559278450524 0.416257605796169 no 1373 0.411939266299461 1969 657714
SGTC_789 1309-1135 70.6 µM 0.222061278703841 0.416439476245366 no 1374 0.412133090215061 1899 3092424
SGTC_2152 5568786 200 µM 0.220348761175049 0.417065027194226 no 1375 0.412799773652042 1941 5399883
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.219934851024775 0.417216252483682 no 1376 0.412960946789411 1863 803109
SGTC_3336 9143619 71.43 µM 0.219738345558872 0.417288051571345 no 1377 0.413037469506144 2006 45595730
SGTC_1759 st043059 70 µM 0.218608498751863 0.417700927989835 no 1378 0.413477515941027 1843 669426
SGTC_536 3852-0578 10.6 µM 0.218508878769428 0.417737336170909 no 1379 0.413516320598893 2032 2869208
SGTC_2541 muurolladie-3-one 83.07 µM 0.217981211330272 0.417930194891797 no 1380 0.413721875311744 1949 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_309 k408-0051 1.48 µM 0.216989008868427 0.418292891297434 no 1381 0.41410845526916 1938 3640463
SGTC_161 4065-0411 162.148 µM 0.216124465089109 0.418608979148019 no 1382 0.414445364979289 1924 1906281 YLR208W SEC13
SGTC_262 fenpropimorph 62.5 µM 0.214423174173891 0.419231145350235 no 1383 0.415108535761344 1908 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_643 k048-0106 28.4 µM 0.214191243701198 0.419315978566581 no 1384 0.415198962075862 1992 6763920
SGTC_264 promethazine 12.5 mM 0.212001402793251 0.42011714110468 no 1385 0.416052969963596 2068 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2020 4017018 200 µM 0.211155399263313 0.420426743920212 no 1386 0.416383006135578 1925 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1696 st025591 34.7925 µM 0.210521646365298 0.42065870392164 no 1387 0.416630279419378 1936 2787147
SGTC_1479 0549-0158 134 µM 0.210371546881023 0.420713645896755 no 1388 0.416688849024825 1923 5440202
SGTC_642 0335-0876 158 µM 0.209808384341662 0.420919798021017 no 1389 0.416908614475877 1929 6812350
SGTC_2295 7971645 200 µM 0.208439839373083 0.421420859920753 no 1390 0.417442776032016 1980 2978226 YKL099C UTP11
SGTC_374 0880-0231 82.3 µM 0.208335321160556 0.42145913215033 no 1391 0.417483577175734 2001 6833587
SGTC_1252 0493-0875 34.8 µM 0.207931287096475 0.421607087354678 no 1392 0.417641309731783 1921 3960963
SGTC_1653 st012112 65 µM 0.204066983305771 0.42302273182603 no 1393 0.419150577457263 2027 720429
SGTC_775 4577-0580 57.3 µM 0.203207512767949 0.423337725083863 no 1394 0.419486420500923 2008 2006902
SGTC_1236 0330-0013 258 µM 0.201815660733275 0.423847938346891 no 1395 0.420030418982873 1926 4617066
SGTC_2105 5350118 200 µM 0.200960835763413 0.424161356148088 no 1396 0.420364598912267 1913 2133313
SGTC_1964 st076914 61 µM 0.200847513325592 0.424202908924955 no 1397 0.420408904792729 2046 24208661
SGTC_355 1311-2252 105 µM 0.200495207603097 0.424332096850875 no 1398 0.420546652842865 1913 5338538
SGTC_3096 9117468 49.47 µM 0.200360887070909 0.424381353346908 no 1399 0.420599173404328 2046 41316311
SGTC_1568 digitonin 820 nM 0.199027344150344 0.424870438969084 no 1400 0.421120677462037 2092 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_3049 9092223 49.47 µM 0.198664424706397 0.425003562113327 no 1401 0.421262627125313 1962 8623917
SGTC_185 k048-0037 25.491 µM 0.195121914133866 0.426303443807976 no 1402 0.422648753645703 2076 6827589
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.194712531661828 0.426453713688565 no 1403 0.422809000418448 2037 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_226 1,3-diallylurea 8.28947 mM 0.194495868318481 0.426533247489784 no 1404 0.42289381528184 2009 74537 YKL182W FAS1
SGTC_2451 5856223 45.7 µM 0.193569508137807 0.426873333805798 no 1405 0.423256487778281 1921 2179896
SGTC_496 calpeptin 138 µM 0.192256995631255 0.427355277792743 no 1406 0.423770451231137 1938 73364 A calpain inhibitor.
SGTC_1127 asiatic acid 681.4 nM 0.192206253291915 0.427373912151408 no 1407 0.423790323905202 1855 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1309 pyrazolanthrone 13.4 µM 0.191278445729992 0.427714664008626 no 1408 0.424153723561663 2073 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1356 1502-0781 85.8 µM 0.190610245913665 0.427960104272299 no 1409 0.424415481147959 1948 567702
SGTC_697 0508-1955 564 µM 0.190174828711936 0.428120054840397 no 1410 0.42458606746995 2085 6243113
SGTC_3098 9119039 49.47 µM 0.189921781546678 0.428213017179146 no 1411 0.424685211949969 2078 17161528
SGTC_2162 5663267 200 µM 0.189569197046734 0.428342553348504 no 1412 0.424823363337659 2058 6456493
SGTC_54 0159-0055 9 µM 0.189264127626081 0.428454639163727 no 1413 0.424942904586032 2098 3319099
SGTC_951 1171-0579 82.7 µM 0.188891127520218 0.428591691291264 no 1414 0.425089073805799 2004 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2096 5468907 200 µM 0.188562345396307 0.428712503464446 no 1415 0.425217923667783 2073 759785
SGTC_2432 5630864 12.22 µM 0.186622217170176 0.42942554619889 no 1416 0.425978422996715 1960 5714970
SGTC_3117 9124945 49.47 µM 0.186545647699645 0.42945369201888 no 1417 0.426008442675464 1875 17592065
SGTC_2995 9067767 71.4286 µM 0.186535530752774 0.429457410887738 no 1418 0.426012409138191 1966 11673567
SGTC_342 k048-0088 23.3 µM 0.186216619679306 0.429574641997397 no 1419 0.426137445643778 1945 6820570
SGTC_2944 9067346 25.62 µM 0.185637029465228 0.429787714161011 no 1420 0.426364706473534 1993 6473075
SGTC_738 1315-0003 72.4 µM 0.185191726399945 0.42995143283601 no 1421 0.426539329114612 2077 6251474
SGTC_619 1652-1634 108 µM 0.18443052111205 0.430231322972585 no 1422 0.42683786404626 1950 5400454
SGTC_1895 st058434 18.3 µM 0.184040498073309 0.430374745450318 no 1423 0.426990842320097 2102 5393175
SGTC_3262 9137218 49.47 µM 0.183381597902388 0.430617062494867 no 1424 0.427249306886858 2051 17650664
SGTC_719 2810-4230 27.3 µM 0.182956618644465 0.430773366679476 no 1425 0.427416028654549 2008 721079
SGTC_2803 7707263 71.43 µM 0.182489173322531 0.430945302087689 no 1426 0.427599425069714 1948 2199229
SGTC_2061 5245884 80.95 µM 0.180322314890871 0.431742484882421 no 1427 0.428449769029172 1984 573863
SGTC_1948 st076329 66.6 µM 0.179734227975768 0.431958888966838 no 1428 0.428680610480128 2101 24208413
SGTC_644 1498-1197 63.3 µM 0.178312789830809 0.432482033636505 no 1429 0.429238667472012 2050 6741615
SGTC_3211 9128781 49.47 µM 0.177729655492857 0.432696684111108 no 1430 0.429467647150714 1847 17194361
SGTC_2453 5731132 22.18 µM 0.176523976351617 0.433140554885395 no 1431 0.429941157014243 2088 1362040
SGTC_2098 5376439 882.5 nM 0.175722054067749 0.433435829322501 no 1432 0.430256154130125 2066 2844116
SGTC_191 3914-0123 66.505 µM 0.175256814221051 0.433607151536044 no 1433 0.430438921887094 1970 3144412
SGTC_1409 3909-8004 61.9 µM 0.174003153760304 0.434068867653266 no 1434 0.43093149185002 2012 2119279
SGTC_886 0866-0150 153 µM 0.17278685778062 0.434516908632152 no 1435 0.431409483818616 2123 271463
SGTC_840 0245-0196 390 µM 0.171705987851757 0.434915133990469 no 1436 0.431834339054754 2092 3827528
SGTC_2938 9059746 27.26 µM 0.171055546325029 0.435154808283578 no 1437 0.432090044753834 2045 6471769
SGTC_1402 3909-7673 35.9 µM 0.168755275178601 0.436002601316886 no 1438 0.432994569454505 2070 5328014
SGTC_1637 st007924 17.4 µM 0.16837369959612 0.43614326420781 no 1439 0.433144648694015 2028 683336
SGTC_1123 mangostin 811.285 nM 0.168276726791263 0.436179013262816 no 1440 0.433182791049402 1958 5281650 An antioxidant.
SGTC_956 1185-0240 191 µM 0.167247277576334 0.436558552128802 no 1441 0.433587743062782 2016 1416193
SGTC_1189 1431-2119 7.28 µM 0.166712546653482 0.436755720592901 no 1442 0.43379811644913 2088 3107275
SGTC_2065 5221596 34.26 µM 0.165799187337093 0.437092534986518 no 1443 0.434157492841244 2044 788581
SGTC_3050 9093513 49.47 µM 0.165045191747548 0.437370616083413 no 1444 0.434454205951117 2062 25236664
SGTC_3107 9121808 49.47 µM 0.161749482354971 0.438586468009914 no 1445 0.435751568142922 2134 662681
SGTC_1194 1488-0194 225 µM 0.161634398105763 0.438628935393296 no 1446 0.4357968838536 2017 1391452
SGTC_1328 1441-0025 69.2 µM 0.161136316926733 0.438812741095454 no 1447 0.435993018601785 2096 4562601
SGTC_1915 st067105 30.6 µM 0.159577748306427 0.439387981006797 no 1448 0.436606854304496 2089 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_579 4491-1009 110 µM 0.15752363966706 0.440146311257795 no 1449 0.437416089351329 2178 1271041
SGTC_2553 4-methylesculetin 85.09 µM 0.157467715927727 0.44016696011553 no 1450 0.437438124701449 1964 5319502
SGTC_1082 camptothecin 424.86 nM 0.157005506636927 0.44033762899708 no 1451 0.43762025413015 1904 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1882 5615643 20 µM 0.156945610716783 0.440359746131472 no 1452 0.43764385654888 2150 2253075
SGTC_2314 7727897 200 µM 0.155710643911616 0.440815810664558 no 1453 0.438130553442069 2000 900724
SGTC_2774 tamoxifen 10.92 µM 0.155214798746164 0.440998944910758 no 1454 0.438325990981994 2108 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_3342 9147791 14.508 µM 0.155095360070304 0.441043059987718 no 1455 0.438373070026347 2095 1838168
SGTC_3331 9141060 1.957 µM 0.152433327114614 0.442026479686061 no 1456 0.439422586484205 1986 4906567 YPR165W RHO1
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.151202205923668 0.442481407027389 no 1457 0.439908105113573 1976 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_745 0469-0705 296 µM 0.150853193169887 0.442610389021637 no 1458 0.440045762135631 2133 3486736
SGTC_95 0471-0001 561.058 µM 0.150709057486385 0.442663657927744 no 1459 0.440102614004568 1939 4015405
SGTC_3283 9109332 35.8195 µM 0.150664516383942 0.442680119403282 no 1460 0.440120182734723 2120 17027281
SGTC_3325 9138760 55.175 µM 0.150262116551304 0.442828842588605 no 1461 0.440278910101842 1998 43844959
SGTC_2749 bexarotene 57.39 µM 0.149905907511437 0.442960500814976 no 1462 0.440419425433572 1993 82146 An retinoic acid receptor inhibitor.
SGTC_3130 9127414 49.47 µM 0.148690789809739 0.44340966709915 no 1463 0.440898814556635 2192 1494646
SGTC_881 0833-0569 170 µM 0.147270362630468 0.443934817849368 no 1464 0.441459312287968 1930 5418700
SGTC_1902 st060212 70.5 µM 0.14654701852462 0.444202285645885 no 1465 0.441744787560547 2167 688944
SGTC_2181 6316240 54.2555 µM 0.146514056572119 0.444214474449709 no 1466 0.441757797059891 2011 12779990
SGTC_607 4491-0986 66.8 µM 0.146392078378382 0.444259580497279 no 1467 0.441805940240714 2135 698981 YDR232W HEM1
SGTC_2847 9005661 71.43 µM 0.146046869544885 0.444387238422329 no 1468 0.441942194261442 2172 2991449
SGTC_285 1486-1325 46 µM 0.145503387684484 0.444588229226008 no 1469 0.442156720614986 2134 22310230
SGTC_32 0928-0142 34.1 µM 0.143593908655024 0.44529450660072 no 1470 0.442910575497967 2147 2244242
SGTC_2161 5662504 8.5105 µM 0.14358473275602 0.445297900999821 no 1471 0.442914198608403 2043 2859334
SGTC_469 w7 172 µM 0.139956537547 0.446640374718468 no 1472 0.444347165164044 2178 45115570 A P450 inhibitor.
SGTC_2321 7390090 138.78 µM 0.137811447478538 0.447434371335219 no 1473 0.445194718455049 1991 649046
SGTC_2987 9018338 71.43 µM 0.137016958486196 0.447728501939221 no 1474 0.445508695299831 2183 5055682
SGTC_694 1315-0438 43.2 µM 0.13679488249073 0.447810722632967 no 1475 0.445596464399127 2098 6793154
SGTC_108 0509-0257 621.132 µM 0.135885507026051 0.448147430199352 no 1476 0.445955896457464 2148 536624
SGTC_3076 9116187 49.47 µM 0.135021578036709 0.4484673452544 no 1477 0.44629740687451 2156 27241210
SGTC_294 k038-0071 157 µM 0.134740246993154 0.448571530083888 no 1478 0.446408625415134 2061 24152826
SGTC_1672 st016598 6.51 µM 0.1345739790754 0.448633105456803 no 1479 0.446474358057798 2012 4665860 YNL267W PIK1
SGTC_1262 0737-0114 49.6 µM 0.134399467700908 0.448697735028143 no 1480 0.446543351264698 2188 765919
SGTC_1345 1488-0192 31.4 µM 0.132633803394816 0.449351717840104 no 1481 0.447241498674415 2151 658348
SGTC_2518 prenyletin 46.28 µM 0.131943639622296 0.449607384483072 no 1482 0.447514435460422 2154 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_672 1441-0018 53.7 µM 0.131628121694092 0.449724273004775 no 1483 0.447639220579248 2065 251141
SGTC_571 k831-0106 44.2 µM 0.131462778102301 0.449785528851508 no 1484 0.447704614875817 2200 4783639
SGTC_3155 9099265 49.47 µM 0.131353571880591 0.449825987801309 no 1485 0.447747807314487 2112 25236499
SGTC_1970 st070122 35.8 µM 0.130729388783355 0.450057246459882 no 1486 0.44799469148132 2134 102928
SGTC_854 0422-0053 192 µM 0.130568968938672 0.450116684452092 no 1487 0.448058145864303 2158 3596728
SGTC_2219 9098279 200 µM 0.129527570616952 0.450502565519841 no 1488 0.448470105253797 2175 902349
SGTC_2291 7917025 104.35 µM 0.129154475407229 0.450640824101084 no 1489 0.448617708890681 2068 2964612
SGTC_1371 2421-0008 32.7 µM 0.128561071428977 0.450860735242219 no 1490 0.448852485555897 2056 2827552
SGTC_3069 9117009 49.47 µM 0.128057593953967 0.451047332115834 no 1491 0.449051697397327 2183 41904981
SGTC_1071 trifluoperazine 6.31 µM 0.127460622939454 0.451268593218577 no 1492 0.449287918635931 2135 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2276 7947513 42.08 µM 0.125957153090725 0.451825905628078 no 1493 0.449882920626566 1918 2105100
SGTC_2612 dictamnine 15.46 µM 0.124365851640706 0.452415879230113 no 1494 0.450512804922035 2076 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2921 7974240 10.71 µM 0.124353080902439 0.452420614396769 no 1495 0.450517860465259 2127 2979074 YDR527W RBA50
SGTC_1916 st067606 49.2 µM 0.123440483118043 0.452759007192563 no 1496 0.450879150648464 2154 19590279
SGTC_1460 k062-0059 9.15 µM 0.12212960902237 0.453245141497152 no 1497 0.451398186394071 2153 1373085
SGTC_1186 1319-0216 26 µM 0.121344174478629 0.453536451507354 no 1498 0.451709216163612 2210 4565136
SGTC_3193 9111931 49.47 µM 0.120167455116273 0.453972931980105 no 1499 0.452175248988197 2109 17087244
SGTC_3002 9075603 71.4286 µM 0.119095640989944 0.454370548353616 no 1500 0.452599792075943 2214 20105405
SGTC_118 0083-0097 135.343 µM 0.118909077882521 0.454439763308557 no 1501 0.452673694841044 2149 5207356
SGTC_1344 1488-0097 29.1 µM 0.117921698646854 0.454806104214538 no 1502 0.453064850083594 2122 747966
SGTC_3301 9125354 19.7965 µM 0.117621156106147 0.454917620207381 no 1503 0.453183920579335 2154 41905162
SGTC_3128 9127691 49.47 µM 0.117422494048449 0.454991335505432 no 1504 0.453262629850638 2117 41316314
SGTC_1594 piperine 70.1 µM 0.116837738461034 0.455208323178007 no 1505 0.453494318787198 2118 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1837 st055472 66.5 µM 0.116592608193982 0.455299288658352 no 1506 0.453591447789927 2148 676091
SGTC_2445 5742597 35.57 µM 0.115940864435022 0.455541155874904 no 1507 0.453849704463529 2084 1774255
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.114707838410578 0.455998786502704 no 1508 0.454338350395064 2117 6708760
SGTC_3119 9125183 49.47 µM 0.114471763554257 0.456086411026278 no 1509 0.454431914329726 2198 22695334
SGTC_1901 st060216 58.6 µM 0.113945865960655 0.456281617487593 no 1510 0.454640353267416 2205 688792
SGTC_429 1112-0049 25.5 µM 0.111906079459078 0.457038859566148 no 1511 0.455448938086943 2010 2836170
SGTC_552 k242-0005 476 µM 0.11180666062287 0.457075771421868 no 1512 0.45548835311386 2102 4088318
SGTC_3321 9137793 26.8275 µM 0.111772494629046 0.45708845653049 no 1513 0.455501898470818 2214 4904192
SGTC_1633 st005664 67.9 µM 0.109256314119405 0.458022780294416 no 1514 0.456499597692063 2167 2063822
SGTC_890 0929-0006 47.2 µM 0.109010697547434 0.458113996676355 no 1515 0.456597002743559 2043 1378169
SGTC_1017 4239-0030 168 µM 0.108617611439522 0.45825998446233 no 1516 0.456752895746336 2021 1149593
SGTC_2434 5670830 169.91 µM 0.10834868940186 0.458359862345638 no 1517 0.456859550677596 2129 1549830
SGTC_668 1682-0499 62.6 µM 0.108092458776569 0.458455029073141 no 1518 0.456961175064685 2092 682214
SGTC_901 1112-0062 60.1 µM 0.10667390376049 0.458981938144539 no 1519 0.457523843116527 2213 1908457
SGTC_3204 9114183 49.47 µM 0.105167837684402 0.459541431241419 no 1520 0.458121315486815 2130 17027248
SGTC_193 1273-0060 1.558 µM 0.104086008177647 0.459943372916086 no 1521 0.45855054719985 2212 2847393 YHR072W ERG7
SGTC_808 0711-0032 135 µM 0.102606961071576 0.460492962522519 no 1522 0.459137458934014 2229 4252555
SGTC_2882 9058044 58.44 µM 0.100003480833532 0.46146055573613 no 1523 0.460170780997474 2081 18076804
SGTC_1243 0416-0003 5.65 µM 0.0991538926991396 0.461776358016353 no 1524 0.460508041340679 2135 2141977
SGTC_2431 5490079 200 µM 0.0986746444689579 0.461954511078519 no 1525 0.460698300688526 2153 5722345
SGTC_3014 9081533 49.47 µM 0.0970553911979502 0.462556499511173 no 1526 0.461341203108872 2238 21367265
SGTC_1590 st077108 57.8 µM 0.0966508747579494 0.462706899693152 no 1527 0.461501826682231 2231 5489485
SGTC_959 1222-0044 107 µM 0.0958035124920365 0.463021968271081 no 1528 0.461838313814591 2263 6083612
SGTC_2344 7990960 76.95 µM 0.0952550759609374 0.463225901835386 no 1529 0.462056112263922 2139 140813
SGTC_1762 st045503 25.4615 µM 0.0902431993640111 0.465089985772903 no 1530 0.46404697811095 2157 4645554
SGTC_2934 9036370 36.88 µM 0.0899752300878738 0.465189674423485 no 1531 0.46415344925081 2216 6462800
SGTC_814 3342-0569 96 µM 0.0896237958080008 0.465320416636678 no 1532 0.464293087090104 2243 4346283
SGTC_1062 mesoridazine 14.2 µM 0.0895592664066613 0.465344423571519 no 1533 0.464318727486706 2245 4078 A neuroleptic.
SGTC_1904 st060225 78 µM 0.0892902962470228 0.465444490154578 no 1534 0.464425602869696 2252 66595
SGTC_3215 9129942 49.47 µM 0.088115966456483 0.46588140862896 no 1535 0.464892253172008 2253 17682944
SGTC_851 0394-0702 453 µM 0.0879702749200865 0.465935617169469 no 1536 0.464950150850731 2258 762646
SGTC_551 k048-0028 34.9 µM 0.0874359020608523 0.466134450682026 no 1537 0.465162516462413 2233 6836383
SGTC_2851 9015922 71.43 µM 0.0870778398759271 0.466267685912474 no 1538 0.465304819841774 2222 2996893
SGTC_2583 asiatic acid 100 µM 0.0866410975549023 0.466430203202008 no 1539 0.46547839879228 2217 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_828 2074-0507 139 µM 0.0852299578176393 0.466955344102514 no 1540 0.46603928716585 2247 X828
SGTC_1439 4092-1168 46 µM 0.0846593346370445 0.467167711939282 no 1541 0.466266113056075 2229 2886240
SGTC_2865 9030313 51.95 µM 0.0843844146323187 0.467270031779278 no 1542 0.466375399204083 2229 42562754
SGTC_876 0720-0963 56.8 µM 0.0833196382613167 0.467666341033812 no 1543 0.466798692756006 2268 765861
SGTC_2837 9008476 45.46 µM 0.0820841753625419 0.46812621987575 no 1544 0.467289888443171 2194 2992805
SGTC_748 act1.228 77.9 µM 0.0819901483062193 0.46816122150589 no 1545 0.467327273796016 2191 4421505 YNR035C ARC35
SGTC_315 k915-0449 187 µM 0.0818859850446379 0.468199996632084 no 1546 0.467368689661601 2173 20970215 YNL149C PGA2
SGTC_1978 st071761 42 µM 0.0808947614790328 0.468568997997919 no 1547 0.467762823023717 2097 5147680
SGTC_2787 5284540 71.43 µM 0.0805888782155835 0.468682874185884 no 1548 0.467884455666733 2172 736958
SGTC_2172 5754775 163.918 µM 0.0796312167272818 0.469039415087947 no 1549 0.468265283343932 2184 2263357
SGTC_2951 9072950 58.06 µM 0.0792356338520024 0.469186699313581 no 1550 0.46842260098243 2280 16488155
SGTC_2953 9074162 66.49 µM 0.0789576048984577 0.469290218147002 no 1551 0.468533172063716 2280 16451992
SGTC_1792 st045773 43.6 µM 0.0783942756351916 0.46949996952315 no 1552 0.468757213450254 2163 2919270
SGTC_1038 k292-0204 154 µM 0.077584176225943 0.469801618714193 no 1553 0.469079414989342 2260 4454212
SGTC_1765 st044815 90.4 µM 0.0763093580790886 0.470276345935681 no 1554 0.469586490442084 2146 645695
SGTC_2524 avocatin b 10.57 µM 0.0758331100824403 0.470453705940841 no 1555 0.469775936960693 2250 6710748
SGTC_3232 9132874 49.47 µM 0.0757708315781275 0.470476899576653 no 1556 0.469800711211216 2210 3784940
SGTC_1233 0325-0408 14.2 µM 0.0751830426219946 0.470695807684669 no 1557 0.470034538096198 2236 12874
SGTC_1627 st003713 25.6 µM 0.073738627745281 0.47123378335836 no 1558 0.470609180971429 2189 16195070 YER133W GLC7
SGTC_425 3825-7017 13.1 µM 0.0720886240022246 0.471848395263185 no 1559 0.471265689701105 2205 3397440
SGTC_3356 9151811 4.48 µM 0.0709776920613294 0.472262245512735 no 1560 0.471707754929936 2245 1859254 YPR165W RHO1
SGTC_42 0133-0086 60.653 µM 0.0701610464107488 0.472566485799148 no 1561 0.472032739174134 2281 162923 Model of phenazepam hydroxylation.
SGTC_197 4544-0043 41.561 µM 0.0678928886963221 0.473411568451212 no 1562 0.472935449845421 2284 896523
SGTC_1313 1220-0047 237 µM 0.0666220720047659 0.473885108865545 no 1563 0.473441286931143 2220 3528706
SGTC_1164 k060-0068 93.7 µM 0.0655867927332511 0.474270909021699 no 1564 0.473853402172058 2295 5963676
SGTC_501 nsc-95397 161 µM 0.0651556479232979 0.474431583662007 no 1565 0.474025036940616 2254 262093
SGTC_1610 st001799 48.1 µM 0.0649096126672224 0.474523275431595 no 1566 0.474122983467511 2226 621897
SGTC_324 1315-0088 19.6 µM 0.0638070877092796 0.474934178025938 no 1567 0.474561917292949 2285 6787421
SGTC_3350 9150499 3.57 µM 0.0635300224636758 0.475037442326867 no 1568 0.474672226527325 2302 4910996 YPR165W RHO1
SGTC_3158 9100007 49.47 µM 0.0629617327575358 0.475249253414223 no 1569 0.474898488334492 2239 19297233
SGTC_711 k292-0785 179 µM 0.0628522583356343 0.475290057169408 no 1570 0.47494207598013 2281 4146315
SGTC_2598 perillyl alcohol 100 µM 0.0628079508884045 0.475306571696417 no 1571 0.474959717239266 2238 10819 An apoptosis inducer.
SGTC_2369 9071472 200 µM 0.0625967181178679 0.475385304174415 no 1572 0.475043821428384 2256 17296037
SGTC_2980 9014342 25.29 µM 0.0625312882655951 0.475409691941547 no 1573 0.475069873126437 2207 2996599
SGTC_3240 9133527 49.47 µM 0.0620551744922292 0.47558715731211 no 1574 0.475259446866679 2272 17617455
SGTC_2753 fluvastatin 17.09 µM 0.0617445337086041 0.475702947337374 no 1575 0.475383137415798 2236 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1747 st037496 66.6 µM 0.0610377210076561 0.475966416383146 no 1576 0.475664584012757 2267 723305
SGTC_2071 5230951 39.92 µM 0.0600285716081794 0.476342601589184 no 1577 0.476066439431832 2286 1799272
SGTC_1878 temozolomide 1 mM 0.0594951897510305 0.47654144130613 no 1578 0.476278848357492 2308 5394 DNA alkylating agent.
SGTC_1138 3761-0006 1.03 µM 0.059007595755423 0.476723216852709 no 1579 0.476473029058981 2289 12061087
SGTC_1953 st076800 12.1 µM 0.0577189876731133 0.477203634496131 no 1580 0.476986234466618 2104 297591
SGTC_2425 5628681 7.85 µM 0.0576388312588751 0.47723351943628 no 1581 0.477018159100763 2262 5714958
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.0558324548668464 0.477907029434476 no 1582 0.477737640007349 2243 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3284 9108171 64.8615 µM 0.0555945594787637 0.477995733811046 no 1583 0.477832399355297 2232 8687505
SGTC_2755 lomerizine 42.69 µM 0.0552898661957536 0.478109346801044 no 1584 0.477953767711167 2278 3949 A calcium channel blocker.
SGTC_2351 9026858 72.31 µM 0.055244122921588 0.478126403550588 no 1585 0.477971988788414 2297 1409300
SGTC_1301 naphtanilide LB 4.81 µM 0.0542253196174803 0.478506305196334 no 1586 0.478377824109836 2304 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1020 4335-0961 93.3 µM 0.0541891417438503 0.478519795927635 no 1587 0.478392235803847 2203 669075
SGTC_2857 9024691 58.44 µM 0.0535924204685978 0.478742316867112 no 1588 0.478629947712497 2265 16478292
SGTC_3192 9110362 49.47 µM 0.0535614367319028 0.47875387106976 no 1589 0.478642290707145 2307 16649480
SGTC_1029 k015-0030 64.7 µM 0.0535007714248288 0.4787764939335 no 1590 0.478666458011607 2222 2208316
SGTC_2292 7671323 168.05 µM 0.0521610823254176 0.479276098316533 no 1591 0.4792001712508 2243 937504
SGTC_1983 st071813 46.9 µM 0.0519234693893249 0.47936471368946 no 1592 0.479294836814281 2202 11838595
SGTC_1698 5-fluorocytosine 1.055 µM 0.0517389369690913 0.479433533917657 no 1593 0.479368355778979 2315 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2620 irigenin 100 µM 0.0514602577847607 0.479537466762431 no 1594 0.479479384781105 2289 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1572 epiandrosterone 68.9 µM 0.0513513022776542 0.479578101879725 no 1595 0.479522794345578 2257 441302 A steroid.
SGTC_274 sirtinol 40.1 µM 0.0495263322958156 0.480258758351362 no 1596 0.480249926403506 2221 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_772 k072-0172 35.3 µM 0.0484441687680024 0.480662398665697 no 1597 0.480681129509833 2245 5861980
SGTC_196 k015-0023 18.111 µM 0.0482079352232912 0.480750514970239 no 1598 0.48077526307434 2274 5211998
SGTC_1486 3970-0793 4.53 µM 0.0480650922437758 0.480803796579171 no 1599 0.480832183194576 2326 2844330
SGTC_1306 1185-0270 9.02 µM 0.0469441430235915 0.481221931709124 no 1600 0.48127887290506 2308 1548076
SGTC_1053 3366-3204 134 µM 0.0448947483221485 0.481986447542246 no 1601 0.482095601428803 2277 3632071 YPR165W RHO1
SGTC_1088 bifonazole 369 nM 0.0430238283128048 0.482684442254742 no 1602 0.482841269595278 2326 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_904 1141-0088 396 µM 0.0424904914983777 0.482883427052381 no 1603 0.483053845795676 2257 1378119
SGTC_2605 digitonin 300 nM 0.0422378773357747 0.482977677387031 no 1604 0.483154533871288 2335 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_858 0438-0351 2.77 µM 0.0401121002765286 0.483770841897027 no 1605 0.484001877470421 2284 2799119
SGTC_460 trequinsin 123 µM 0.0395273838835739 0.48398902118064 no 1606 0.484234960695264 2339 5537 A vasodilator.
SGTC_2331 7980721 200 µM 0.0387523644121896 0.484278216949393 no 1607 0.484543911986316 2301 2981221
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.0386635368226002 0.484311363180743 no 1608 0.484579322529614 2308 17037758
SGTC_2571 chrysanthemic acid 100 µM 0.0380571597360729 0.484537637151325 no 1609 0.484821054062202 2249 2743 An insecticide.
SGTC_2234 tolnaftate 200 µM 0.0376567463646388 0.484687057014573 no 1610 0.484980681458734 2337 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_293 4049-0273 38.5 µM 0.0372956368593941 0.484821811933719 no 1611 0.485124642178054 2293 1380311
SGTC_2024 5144227 134 µM 0.0369914774665571 0.484935316174656 no 1612 0.485245900543835 2328 3475211
SGTC_1917 st066507 28.5 µM 0.0369673891275083 0.484944305357979 no 1613 0.485255503832355 2270 3156428
SGTC_3269 9137823 49.47 µM 0.0367651984321757 0.485019758317946 no 1614 0.485336111452813 2320 17682936
SGTC_3199 9111318 49.47 µM 0.036215172107056 0.485225018314794 no 1615 0.485555394166713 2338 8548020
SGTC_99 0109-0120 622.8 µM 0.0354844415732257 0.485497719939837 no 1616 0.485846726194375 2338 759414
SGTC_2196 6573537 42.6665 µM 0.0354108363536738 0.485525189079767 no 1617 0.485876071985704 2343 2903087
SGTC_2000 st075254 36.4 µM 0.0353709266448102 0.485540083233991 no 1618 0.485891983688028 2343 17234175
SGTC_768 0384-0033 77.3 µM 0.0342671000817878 0.485952035104348 no 1619 0.486332079892714 2297 3965305 YMR134W ERG29
SGTC_1434 4073-0095 163 µM 0.0328215161231115 0.486491554614995 no 1620 0.486908460034898 2342 24133745
SGTC_3166 9102297 49.47 µM 0.0325566338406666 0.48659041644548 no 1621 0.487014076331808 2301 25237072
SGTC_80 0159-0065 512.242 µM 0.0314149786300418 0.487016524981411 no 1622 0.487469297913952 2351 1548079
SGTC_2669 eugenol 100 µM 0.0301487802215589 0.487489135025042 no 1623 0.487974198701257 2352 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_417 st075190 100 µM 0.0298154769192521 0.487613543822537 no 1624 0.488107107728877 2358 222757
SGTC_1158 4092-0494 91.8 µM 0.0296840965496988 0.487662583193859 no 1625 0.488159497724061 2300 1148199
SGTC_1844 rapamycin 4 nM 0.028969853814379 0.487929186500667 no 1626 0.488444316834862 2338 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2849 9019321 12.99 µM 0.0287375309397717 0.488015906152235 no 1627 0.488536961678948 2322 16489627
SGTC_3287 9117173 37.0625 µM 0.0286915139405093 0.488033083082394 no 1628 0.488555312238773 2360 2789709
SGTC_1981 st071826 47 µM 0.0284694507437227 0.4881159737188 no 1629 0.488643866461832 2270 11838600
SGTC_580 1123-0028 41 µM 0.0279552873036426 0.48830790003341 no 1630 0.488848906379113 2346 1677248 YPR107C YTH1
SGTC_3239 9133757 49.47 µM 0.026752221995523 0.48875698931662 no 1631 0.489328680443935 2353 17036923
SGTC_1724 st037281 8.293 µM 0.0259941732630094 0.489039966816245 no 1632 0.489630992972352 2350 574124 YDL195W SEC31
SGTC_1061 3448-9325 110 µM 0.025448623125043 0.489243622599361 no 1633 0.489848564002419 2368 723482
SGTC_1359 1582-0056 520 nM 0.0253583309928331 0.489277329241444 no 1634 0.48988457373046 2340 3661189
SGTC_319 1348-1596 45.5 µM 0.0249889799894231 0.4894152111757 no 1635 0.490031876779873 2361 5380505
SGTC_654 1124-0271 80.9 µM 0.0248714259284949 0.489459095392764 no 1636 0.490078759493564 2337 5403748
SGTC_3077 9117319 49.47 µM 0.0242393415667976 0.489695061574886 no 1637 0.490330848653866 2366 17154678
SGTC_359 0081-0058 15.9 µM 0.0232002542281118 0.490082975621077 no 1638 0.490745267909153 2348 3494159
SGTC_468 gf-109203x 121 µM 0.0229718845902047 0.490168232275413 no 1639 0.490836349938002 2368 2396 A protein kinase C inhibitor.
SGTC_3268 9137683 49.47 µM 0.0225582935366408 0.490322638309121 no 1640 0.491001306145133 2359 1953228
SGTC_1987 st072290 61.9 µM 0.0223638739706322 0.490395221508481 no 1641 0.491078848767424 2301 54697379
SGTC_1697 st025554 27.742 µM 0.0213657381541732 0.490767863295347 no 1642 0.491476952157704 2365 1269519
SGTC_2908 7930301 100 µM 0.0209213001018843 0.490933791413049 no 1643 0.491654217658764 2374 2223178
SGTC_1244 0416-0015 52.5 µM 0.0207813989883896 0.490986022929236 no 1644 0.491710017996247 2351 96201
SGTC_2786 7743617 45.45 µM 0.0202312102638871 0.491191435160076 no 1645 0.491929465393282 2345 583674
SGTC_2337 9009472 200 µM 0.0173574210118975 0.49226439728896 no 1646 0.493075738571693 2359 5742383
SGTC_1734 st037168 69.4 µM 0.0156797033534649 0.492890818765095 no 1647 0.493744959692706 2294 708907
SGTC_3089 9117425 49.47 µM 0.013738547420593 0.493615623856245 no 1648 0.494519284975213 2334 9401657
SGTC_563 tetrahydrosecaminediol 614 µM 0.0132906561021323 0.493782864355034 no 1649 0.494697951440714 2382 334274 A psychoactive constituent of the cannabis plant.
SGTC_2830 7992007 71.43 µM 0.0129627438386163 0.493905305937023 no 1650 0.494828758236145 2379 1952075
SGTC_1961 st076550 68.7 µM 0.0124541973869213 0.494095196984253 no 1651 0.495031622532605 2379 1579337
SGTC_1497 4476-2978 41.3 µM 0.0123299206417186 0.494141602077656 no 1652 0.495081197974079 2362 1528379
SGTC_1523 st012844 44.7 µM 0.0111315390437895 0.494589083253014 no 1653 0.495559250139428 2328 4274103
SGTC_3006 9075424 71.4286 µM 0.0103493214701785 0.494881170583991 no 1654 0.49587129179547 2380 7465181
SGTC_2515 chrysin 20.77 µM 0.00976711470699378 0.495098573804677 no 1655 0.496103546937298 2388 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2307 7538926 6.34 µM 0.00962144823143828 0.495152967702096 no 1656 0.496161656722566 2372 96582
SGTC_23 0213-0011 39.996 µM 0.00922430138335815 0.495301268339457 no 1657 0.496320088356979 2386 627608
SGTC_356 1634-0012 32.5 µM 0.00894058505149259 0.495407212706002 no 1658 0.496433270128698 2393 735457
SGTC_1400 3771-8998 51.5 µM 0.00810862658342021 0.495717881585436 no 1659 0.49676516146827 2384 670767
SGTC_2931 9014674 55.67 µM 0.00543304630167326 0.496717010054373 no 1660 0.497832538782073 2393 2996810
SGTC_2771 fluoxetine 41.05 µM 0.00525029716228793 0.496785253967394 no 1661 0.497905444100252 2392 3386 A selective serotonin reuptake inhibitor.
SGTC_1378 2093-0007 380 nM 0.00485559331741961 0.496932648330686 no 1662 0.498062906140991 2389 3618014
SGTC_1260 0700-1617 7.75 µM 0.00476532375498243 0.496966357777302 no 1663 0.498098918069399 2389 2853078
SGTC_3115 9123671 49.47 µM 0.0047128292146399 0.496985960872278 no 1664 0.498119860125861 2397 3286988
SGTC_2720 fluspirilene 36.88 µM 0.00445754398803272 0.497081292423164 no 1665 0.498221703125464 2388 3396 An atypical antipsychotic.
SGTC_3125 9127534 49.47 µM 0.00428762916441737 0.497144744067192 no 1666 0.498289488684573 2400 1639235
SGTC_2696 st077691 74.316 µM 0.00373135547780944 0.497352474997372 no 1667 0.498511407990976 2391 757133
SGTC_237 nikkomycin 200 µM 0.00321771097101822 0.497544287425411 no 1668 0.498716321262679 2396 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2243 6634756 200 µM 0.000966522384434398 0.498384964352241 no 1669 0.499614413415928 2401 885676
SGTC_818 4072-2707 53.5 µM 0.000804655829337153 0.498445411620529 no 1670 0.499678988803147 2401 882871
SGTC_2397 5161689 200 µM 0.000307909238255482 0.498630916337954 no 1671 0.499877161988275 2404 2259942
SGTC_1830 st055982 50.3 µM -0.000531937876746959 0.498944548939733 no 1672 0.499787787500427 2407 455313 An antimicrobial agent.
SGTC_1565 sinapyl alcohol 95.1 µM -0.000631695492914134 0.498981802482344 no 1673 0.499747989976298 2406 5280507 A phenol propionate derived from cinnamic acid.
SGTC_3123 9126162 49.47 µM -0.00129376488578308 0.499229046273732 no 1674 0.49948386263015 2413 25239884
SGTC_2231 micatex 6.853 µM -0.0019271867992775 0.499465592203032 no 1675 0.499231164179452 2414 20737 An antifungal of unknown mechanism.
SGTC_2477 5967686 25.23 µM -0.0025095598045593 0.499683074527303 no 1676 0.49899883153964 2413 776118
SGTC_626 0214-0009 33 µM -0.00266878742851271 0.499742536769829 no 1677 0.498935309121226 2408 3437874
SGTC_2557 derrustone 83.84 µM -0.00298971896952302 0.499862386022136 no 1678 0.498807276473383 2419 629853 An antioxidant.
SGTC_1838 st055369 84.5 µM -0.00372672250398003 0.499862386022136 no 1679 0.49851325626727 2413 676036
SGTC_1554 st069299 38.7 µM -0.00376604946714948 0.499847699689342 no 1680 0.498497567189005 2417 24207999
SGTC_2050 5263056 171 µM -0.00516897246640155 0.499323789853338 no 1681 0.497937887519607 2418 763468 YGL055W OLE1
SGTC_1892 st058411 7.36 µM -0.00606013706397791 0.498990992451954 no 1682 0.497582369898177 2416 3934738
SGTC_1381 2324-0066 62.1 µM -0.00640665247367746 0.498861589566566 no 1683 0.497444132936768 2426 10885928
SGTC_1405 3909-7894 12 µM -0.00703090985913057 0.498628466892294 no 1684 0.497195095896982 2425 7104060
SGTC_1097 itavastatin 7.23 µM -0.00766254185523144 0.498392590720453 no 1685 0.496943117992539 2426 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_640 3381-0960 37.1 µM -0.00792249882201271 0.498295512747178 no 1686 0.496839413316394 2427 1745025
SGTC_1708 st033234 31.827 µM -0.00848225909197923 0.498086476989544 no 1687 0.496616108792712 2430 674664
SGTC_3092 9117248 49.47 µM -0.00854971802717061 0.498061285293807 no 1688 0.496589197547125 2426 17141857
SGTC_2257 7960413 200 µM -0.00863036024791851 0.498031170475095 no 1689 0.496557027142622 2431 2974689 YIL048W NEO1
SGTC_2256 7954252 200 µM -0.00936497975437323 0.497756836637671 no 1690 0.49626396823106 2444 2972920
SGTC_2474 5321570 43.32 µM -0.0098144147633271 0.497589001654419 no 1691 0.496084677849371 2455 2841384
SGTC_2339 9000433 200 µM -0.0104631429568148 0.497346744283203 no 1692 0.495825886050611 2434 2988954
SGTC_3150 9097574 49.47 µM -0.0109103719556224 0.497179734190927 no 1693 0.495647477683465 2425 17217476
SGTC_421 streptovitacin 30 mM -0.0110126189235923 0.497141551861454 no 1694 0.495606689495431 2518 91467 include heat shock
SGTC_162 k030-0015 37.8 µM -0.0118819922642003 0.496816900791495 no 1695 0.495259882447011 2434 1809920 YMR134W ERG29
SGTC_2600 tangeritin 87.95 µM -0.0127657062071107 0.496486896655898 no 1696 0.494907358374085 2429 68077 A bioactive flavone.
SGTC_2019 4016004 108 µM -0.0136246393775459 0.496166148673353 no 1697 0.494564723456715 2453 45595336
SGTC_567 1080-0542 68.4 µM -0.0138506293310956 0.496081758551146 no 1698 0.494474575016416 2431 5950415
SGTC_1358 1509-0022 2.48 µM -0.0140695696311995 0.496000001107464 no 1699 0.494387238984624 2447 3258434
SGTC_1165 k072-0275 30.3 µM -0.0145065298617339 0.495836830413384 no 1700 0.494212934868054 2438 6153523 YGL055W OLE1
SGTC_1117 retinoic acid 1.10837 µM -0.0148117950299482 0.495722838003937 no 1701 0.494091164770547 2435 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2436 5633522 8.09 µM -0.0154334454616483 0.495490701798176 no 1702 0.493843190490396 2434 5724242
SGTC_2057 5236571 38.335 µM -0.0164459122774237 0.495112630555404 no 1703 0.493439325996192 2441 54684039 YBR257W POP4
SGTC_888 0916-0002 6.97 µM -0.0191973609088836 0.494085218948072 no 1704 0.492341831452746 2528 2802138 YIL048W NEO1
SGTC_464 bw-b 70c 158 µM -0.0193959224590186 0.494011076008546 no 1705 0.492262631602081 2486 5353454
SGTC_122 0236-0016 402.397 µM -0.019576530656039 0.493943637035807 no 1706 0.49219059303449 2441 6808838
SGTC_397 arbidol 50 µM -0.0203257379605507 0.493663885429292 no 1707 0.491891762051343 2475 131410 A RNA synthesis inhibitor.
SGTC_430 0958-0115 16.4 µM -0.0205157646799787 0.493592930551214 no 1708 0.491815968163613 2465 6833180
SGTC_1857 st056007 79.3 µM -0.0205702154280785 0.493572598994037 no 1709 0.491794250041164 2447 619834
SGTC_733 4069-0007 56.1 µM -0.0208354211789222 0.493473573121587 no 1710 0.491688470925704 2445 5717425 YNL287W SEC21
SGTC_1132 3456-3614 2.5 µM -0.0212418710381236 0.493321808522856 no 1711 0.491526356774949 2465 3125502
SGTC_3159 9100096 49.47 µM -0.0219831651686226 0.493045018690885 no 1712 0.491230692271496 2437 25236875
SGTC_1529 apigenin 74 µM -0.0225855755491731 0.492820088750869 no 1713 0.49099042496913 2455 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2922 7999257 32.47 µM -0.0229909738056452 0.49266872111685 no 1714 0.490828736453645 2448 2988377
SGTC_387 norethindrone acetate 66.7 µM -0.0237997415680482 0.492366746519205 no 1715 0.490506173095426 2468 541197
SGTC_2898 9056270 58.44 µM -0.024155362216642 0.492233967623107 no 1716 0.490364341760573 2446 19154699
SGTC_3310 9130229 44.1445 µM -0.0253075742042525 0.491803769580156 no 1717 0.489904816262989 2518 7761258
SGTC_586 0957-0265 8.15 µM -0.0283397814956839 0.490671690007239 no 1718 0.488695576142838 2443 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2032 5185112 25.99 µM -0.0285940157393745 0.490576774522393 no 1719 0.488594192441367 2464 5718189
SGTC_1275 0867-0008 21.1 µM -0.0288998333446663 0.490462601679274 no 1720 0.488472239269589 2462 3422836
SGTC_1363 1636-0063 10.4 µM -0.0299139717701078 0.490083992536815 no 1721 0.488067831487665 2463 6072185
SGTC_1148 3909-7663 27.7 µM -0.0305438243770631 0.489848853614747 no 1722 0.487816671436003 2546 4084526
SGTC_2486 5283202 22.39 µM -0.0313318117836334 0.489554684197495 no 1723 0.487502460360555 2494 1377751
SGTC_2805 7950783 58.44 µM -0.0319370416201579 0.489328745212398 no 1724 0.487261129377719 2487 1178958 YDL195W SEC31
SGTC_448 monastrol 171 µM -0.0323330064720121 0.489180929006738 no 1725 0.487103243799884 2442 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_312 4092-0653 6.84 µM -0.0333347793813343 0.488806967469574 no 1726 0.48670380961364 2539 1148278
SGTC_1157 4092-0394 27.6 µM -0.0348323054868072 0.488247959858227 no 1727 0.486106730100674 2560 3659885
SGTC_2044 5102272 200 µM -0.0350959899984341 0.48814953211434 no 1728 0.486001599480898 2507 592666
SGTC_3230 9131665 49.47 µM -0.0360628681990776 0.487788623546406 no 1729 0.485616114970509 2471 15943720
SGTC_2977 9011197 71.43 µM -0.0363914295730774 0.487665983044072 no 1730 0.485485123932244 2555 2704722
SGTC_2134 5324836 1.464 µM -0.0384541682732932 0.486896061737634 no 1731 0.484662786426458 2490 699272
SGTC_877 0771-0151 33.1 µM -0.0391449079246909 0.48663825256755 no 1732 0.484387428520727 2551 6166523
SGTC_1596 piperlongumine 63 µM -0.0391581821463395 0.486633298199398 no 1733 0.484382136929617 2477 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2780 5215298 71.43 µM -0.0398651613829622 0.486369433719651 no 1734 0.484100313100274 2476 2834131
SGTC_2323 6148992 148.28 µM -0.0404065949097052 0.486167359570802 no 1735 0.483884486283581 2518 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.040526598936925 0.486122572074096 no 1736 0.483836650785774 2598 6710655
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.041167817275563 0.48588326171728 no 1737 0.483581055002933 2534 5282309
SGTC_3219 9131112 49.47 µM -0.0412491303911107 0.485852915050989 no 1738 0.483548643294667 2478 17612988 YMR079W SEC14
SGTC_524 r073-0010 27.8 µM -0.0431672374195879 0.485137087225625 no 1739 0.482784110742313 2485 2772106
SGTC_419 nsc-638432 893 µM -0.0433772066848872 0.485058730626353 no 1740 0.482700423513192 2520 368090
SGTC_3220 9131269 49.47 µM -0.0434878042392324 0.485017457921196 no 1741 0.482656343068581 2476 17722206
SGTC_1103 duloxetine 36.1 µM -0.0438211870506836 0.484893047368378 no 1742 0.482523469240312 2577 60835 A selective serotonin reuptake inhibitor.
SGTC_1839 st053978 48 µM -0.0448603935819385 0.484505249646366 no 1743 0.482109293192679 2473 3788398
SGTC_2088 5278280 127.392 µM -0.0449023350034278 0.484489598791562 no 1744 0.482092577830014 2522 791502
SGTC_2768 sulfasalazine 50.2 µM -0.0459927639003922 0.484082702958411 no 1745 0.481658008689456 2494 5384001 An antioxidant and salicylic acid derivative.
SGTC_456 gingerol 170 µM -0.0482966784788094 0.483223047418346 no 1746 0.480739900828292 2554 442793 A herb.
SGTC_2130 NSC 7 2.4545 µM -0.0506112659623725 0.482359488050852 no 1747 0.479817642696081 2522 21448
SGTC_2026 5148700 152 µM -0.0508889901380597 0.482255876228359 no 1748 0.479706989370255 2501 79838
SGTC_746 1095-0025 46.6 µM -0.0520116540768618 0.481837051168409 no 1749 0.479259703686739 2513 6749286
SGTC_3081 9117243 49.47 µM -0.0521939688458 0.481769038042632 no 1750 0.479187069274537 2559 45595589
SGTC_55 0767-0285 6.563 µM -0.0527735189923232 0.481552838483102 no 1751 0.478956180436447 2497 3116166
SGTC_3149 9097855 49.47 µM -0.0537338379429799 0.481194606160918 no 1752 0.478573611477864 2554 25236625 YMR079W SEC14
SGTC_2531 methyl deoxycholate 70.07 µM -0.0543785196450587 0.480954125996114 no 1753 0.478316796184372 2514 16667744 Haematoxylin.
SGTC_1518 st038567 90.8 µM -0.0545839100036946 0.480877512418758 no 1754 0.478234978801908 2495 77966
SGTC_674 0498-0004 451 µM -0.0549387532206611 0.48074515242735 no 1755 0.478093628939685 2517 4231473
SGTC_2002 4023503 131 µM -0.0555319472594323 0.480523889995337 no 1756 0.477857339488598 2490 4736863 YCR052W RSC6
SGTC_617 3770-0098 35 µM -0.0557014202154839 0.480460677380203 no 1757 0.477789834046343 2522 5962639
SGTC_2811 7967822 32.47 µM -0.0558903934500222 0.480390191832431 no 1758 0.477714561892575 2557 2232244
SGTC_1142 3253-1408 9.78 µM -0.0564406197266498 0.480184965207204 no 1759 0.477495399323752 2485 256655
SGTC_1379 2144-0755 36.5 µM -0.0569474013878497 0.479995947454864 no 1760 0.47729354735253 2511 5392327
SGTC_384 k007-0144 5.16 µM -0.0583806963441862 0.479461386320122 no 1761 0.476722695314535 2561 6824886
SGTC_1465 k213-0056 144 µM -0.05939342014962 0.479083703453887 no 1762 0.476319376884726 2500 24048857 YMR208W ERG12
SGTC_1299 1079-1439 3.74 µM -0.0599226399623748 0.478886344894546 no 1763 0.476108624105206 2523 323161
SGTC_2056 5235370 200 µM -0.0619404207352707 0.478133914730057 no 1764 0.475305139093482 2557 5511916
SGTC_67 0335-0847 266 µM -0.0623661251372371 0.47797517948411 no 1765 0.475135635325268 2754 4552207 YOR254C SEC63
SGTC_2470 5664817 21.68 µM -0.0632803890534076 0.477634283628388 no 1766 0.47477161586459 2514 2859561
SGTC_3315 9136395 68.55 µM -0.0645486461984295 0.477161423684454 no 1767 0.47426668688876 2525 16876844
SGTC_3037 9091026 49.47 µM -0.0654169408925445 0.476837705173353 no 1768 0.473921018044175 2544 25236398 YIL048W NEO1
SGTC_2856 9022925 19.48 µM -0.0661381548083995 0.476568833078724 no 1769 0.473633917096241 2610 4944862
SGTC_919 tnp00227 403.569 nM -0.0665237640194465 0.476425080437102 no 1770 0.473480419330336 2564 1269246 A methoxyflavone. YNL221C POP1
SGTC_1197 1601-0112 267 µM -0.0666744898844537 0.476368891633941 no 1771 0.473420421615985 2513 7350313
SGTC_806 3966-4455 5.86 µM -0.0675419298991224 0.476045529519351 no 1772 0.473075141491798 2545 714982
SGTC_2352 9027995 87.8 µM -0.0677272433723596 0.475976450865033 no 1773 0.473001381011728 2574 2997347
SGTC_389 tpck 16.7 µM -0.067739506091616 0.475971879759576 no 1774 0.472996500103735 2561 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1035 k081-0041 55.2 µM -0.0696055202217079 0.47527633328539 no 1775 0.472253821549286 2518 731709
SGTC_3305 9127027 53.8275 µM -0.0697695684659368 0.475215188779236 no 1776 0.472188534489865 2584 41905295
SGTC_1122 capsaicin 818.572 nM -0.0698911016787437 0.475169890967125 no 1777 0.472140167821313 2645 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1664 st014217 9.02 µM -0.0709939299273597 0.47475885999034 no 1778 0.471701293259291 2542 3982782
SGTC_1392 3455-1037 33.9 µM -0.0725549953330758 0.474177087192531 no 1779 0.471080120400614 2637 981132
SGTC_3141 9094609 49.47 µM -0.0741637519243926 0.473577598624111 no 1780 0.470440044082206 2540 25236309 YDL196W YDL196W
SGTC_2726 cimetidine 79.27 µM -0.0752812407905432 0.473161211657502 no 1781 0.46999547340214 2546 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1743 st037606 46.3785 µM -0.0767462771871853 0.4726153696726 no 1782 0.469412694602241 2575 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2373 9071805 200 µM -0.0773124094236165 0.472404454335697 no 1783 0.469187509581692 2546 10149009
SGTC_65 0798-0905 34.986 µM -0.077761446523406 0.472237168864967 no 1784 0.46900890738234 2644 3602145
SGTC_612 0302-0167 22.4 µM -0.0791327547848688 0.471726328491257 no 1785 0.468463515321535 2604 235821
SGTC_885 0865-0106 16.8 µM -0.080880763369041 0.471075227084033 no 1786 0.467768389222475 2545 2793380
SGTC_606 k015-0008 38.6 µM -0.0811564369223007 0.470972550711903 no 1787 0.46765877174317 2585 1970475
SGTC_144 4161-2749 112.381 µM -0.0813982047508055 0.470882504331021 no 1788 0.467562638388159 2537 797501 YMR168C CEP3
SGTC_9 0092-0002 10.449 µM -0.0819323828261349 0.470683555095232 no 1789 0.467350241613793 2565 759368
SGTC_3060 1327-0027 12.5 µM -0.081948263049971 0.470677640777799 no 1790 0.467343927553686 2592 16000455 YPR107C YTH1
SGTC_3051 9093778 49.47 µM -0.0822167935702909 0.470577632164277 no 1791 0.467237159658945 2554 17217378
SGTC_2534 helenine 20.12 µM -0.0829943316813342 0.470288064736362 no 1792 0.466928023364326 2559 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2254 7938975 95.19 µM -0.0835462600953603 0.470082527435021 no 1793 0.466708597849169 2691 2969277
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.0844958858532766 0.469728906933915 no 1794 0.466331086879468 2615 6728940
SGTC_2301 7769476 200 µM -0.0853290958398401 0.46941865685202 no 1795 0.465999880372938 2611 977820
SGTC_2709 st078560 56 µM -0.0853301616920496 0.469418259988244 no 1796 0.465999456704634 2588 17250903
SGTC_1109 tnp00067 928.257 nM -0.0853611755839258 0.469406712162067 no 1797 0.465987128930773 2580 676295
SGTC_69 0096-0274 206.684 µM -0.085485736629517 0.469360332905126 no 1798 0.465937617240714 2840 6741392
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.0865241677637655 0.468973698052049 no 1799 0.465524872506586 2544 1241132 A phosphatase inhibitor.
SGTC_659 k018-0002 107 µM -0.0878908493181204 0.468464891700896 no 1800 0.464981714822423 2595 6797879 YHR007C ERG11
SGTC_1330 1469-0054 61.8 µM -0.087927704080655 0.468451171630135 no 1801 0.46496706860219 2654 7102664
SGTC_2610 ononetin 44.17 µM -0.0898062636615218 0.467751882684904 no 1802 0.464220585312186 2634 259632
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.0902612407379995 0.467582533531053 no 1803 0.464039809897809 2574 364106
SGTC_688 0527-0193 473 µM -0.0911148629464924 0.467264818655233 no 1804 0.46370066142228 2615 4007154
SGTC_573 3702-0553 84.7 µM -0.0915817519487049 0.467091053188691 no 1805 0.463515175173647 2576 1222756
SGTC_2225 6654152 15.4 µM -0.0916566813992942 0.467063166734725 no 1806 0.463485407844993 2571 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_777 1315-0167 517 µM -0.0917802810231153 0.467017167081502 no 1807 0.463436305694712 2656 4221767
SGTC_403 arphamenine a 50 µM -0.0924145411994185 0.466781123564142 no 1808 0.463184343330855 2579 5487158 An arginine aminopeptidase inhibitor.
SGTC_2215 7188065 200 µM -0.0925835183084866 0.466718239743245 no 1809 0.463117218993108 2656 940217
SGTC_3241 9133421 49.47 µM -0.093266027274139 0.466464256582519 no 1810 0.462846110359029 2551 17018221
SGTC_2570 licareol 100 µM -0.0933921336502292 0.46641732990531 no 1811 0.462796019821781 2688 443158
SGTC_753 1322-0200 289 µM -0.0934787144843525 0.466385111734432 no 1812 0.462761629511276 2692 5403907
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.093927618815338 0.466218070490307 no 1813 0.462583327088943 2564 229346 A bile salt which induces apoptosis.
SGTC_1480 1070-0044 41.2 µM -0.0941477787644857 0.466136149212757 no 1814 0.462495883468826 2670 3124987
SGTC_75 0159-0059 199.013 µM -0.0943777953241205 0.466050561833822 no 1815 0.462404526914227 2643 5377270
SGTC_1159 4092-0538 61.2 µM -0.0947258568320447 0.465921053831419 no 1816 0.462266289769697 2573 717301
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.0978770531305461 0.464748711060676 no 1817 0.461014960715527 2593 65057 A dermal irritant. YDR527W RBA50
SGTC_963 1269-2853 151 µM -0.103571791964747 0.462630874457694 no 1818 0.458754586997294 2623 3668223
SGTC_3027 9089541 49.47 µM -0.10360490773831 0.462618561953937 no 1819 0.458741446407398 2680 9943819
SGTC_198 3454-2873 16.191 µM -0.103703759948377 0.46258180873875 no 1820 0.458702221369567 2611 710957
SGTC_2793 7325131 81.82 µM -0.104226115098608 0.462387602598248 no 1821 0.458494954990287 2663 4176441
SGTC_2294 7971431 200 µM -0.105587538010175 0.461881482158118 no 1822 0.457954806351024 2680 5741572
SGTC_2083 5306046 65.942 µM -0.106998582962907 0.461356979451239 no 1823 0.457395051967011 2628 539837
SGTC_2925 9010536 32.5 µM -0.107544911976164 0.461153920257978 no 1824 0.45717834864829 2669 2994177
SGTC_1153 4055-0057 267 µM -0.108025310847911 0.46097537430081 no 1825 0.456987807269247 2595 882706
SGTC_3264 9137442 49.47 µM -0.108391420179265 0.460839310691262 no 1826 0.45684260337173 2711 17015726
SGTC_653 0203-0016 55.2 µM -0.108443014092754 0.46082013631165 no 1827 0.456822140992716 2674 295302
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.110108106849354 0.460201369828164 no 1828 0.45616181945871 2595 16486 A toxic proline analog.
SGTC_1711 st032263 62.8 µM -0.110203176831894 0.460166043688078 no 1829 0.456124121437231 2649 3958979
SGTC_511 blebbistatin 171 µM -0.112654076494807 0.459255446790936 no 1830 0.455152405519842 2750 3476986 A myosin inhibitor.
SGTC_554 4483-2211 187 µM -0.113469242994025 0.458952630403901 no 1831 0.45482927305213 2702 747107
SGTC_2667 digitoxin 100 µM -0.114870048216087 0.458432317864058 no 1832 0.454274062985264 2642 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3344 9148862 3.898 µM -0.114954728621651 0.458400866602169 no 1833 0.454240502703627 2715 4905352
SGTC_1799 st045822 46.1415 µM -0.116003496134239 0.45801136411542 no 1834 0.453824885495008 2613 3674992
SGTC_287 k060-0039 29.6 µM -0.117215710087141 0.457561209400496 no 1835 0.453344558944343 2704 5861974
SGTC_1234 0326-0494 15.5 µM -0.118225729594438 0.457186180987496 no 1836 0.452944401826439 2721 1547813
SGTC_2012 4023501 200 µM -0.118531499513194 0.457072653645861 no 1837 0.452823269005849 2674 3477460
SGTC_3345 9148410 3.559 µM -0.119460453388069 0.456727769878262 no 1838 0.45245528462371 2658 4903596
SGTC_1939 st074455 53.6 µM -0.120194810835657 0.456455155107433 no 1839 0.452164414164755 2786 1644229
SGTC_757 1066-0008 322 µM -0.121045385611921 0.456139422720601 no 1840 0.451827543470089 2781 6842497
SGTC_3063 1327-0034 4 µM -0.121123909823025 0.456110276016281 no 1841 0.451796445650112 2611 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2806 7952793 58.44 µM -0.121700197352055 0.455896376205046 no 1842 0.451568228468094 2741 2972490
SGTC_1848 st056003 16.4 µM -0.122234916973668 0.45569791652511 no 1843 0.451356487019065 2594 146492
SGTC_1228 0124-0032 52.5 µM -0.122382049304541 0.45564331071247 no 1844 0.4512982271109 2686 X1228
SGTC_2072 5231554 129 µM -0.122719325768194 0.455518139108086 no 1845 0.451164679895652 2708 789545
SGTC_938 3126-1755 342 µM -0.122728809720563 0.455514619443494 no 1846 0.451160924731446 2642 1777771
SGTC_1446 4239-0190 62 µM -0.123673620308941 0.455164000856474 no 1847 0.450786849611655 2648 1340085
SGTC_1263 0774-1208 64.8 µM -0.124338848185702 0.454917156163956 no 1848 0.450523494770337 2671 906585
SGTC_3197 9113331 49.47 µM -0.124536924689951 0.454843659695943 no 1849 0.450445083128233 2761 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_3161 9100388 49.47 µM -0.125155206362209 0.454614255670486 no 1850 0.450200339238673 2646 25236368
SGTC_1208 2323-2347 50.3 µM -0.125209475103669 0.45459412079959 no 1851 0.450178858115555 2682 5412760
SGTC_2166 5933061 31.504 µM -0.12571002110386 0.454408412969522 no 1852 0.4499807345538 3110 2877375
SGTC_1891 st059073 26.2 µM -0.126638811440185 0.454063848419268 no 1853 0.449613138569757 2756 688754
SGTC_937 3122-0005 46.7 µM -0.126818891360543 0.453997045992842 no 1854 0.449541871660142 2743 759535
SGTC_678 1218-2179 85.9 µM -0.127333452696865 0.453806171557506 no 1855 0.449338242185264 2627 6820081 YOR116C RPO31
SGTC_1739 st037196 92.5 µM -0.127754382076416 0.453650037447565 no 1856 0.449171675988398 2696 612214
SGTC_721 1187-1332 279 µM -0.130339821617044 0.452691185910275 no 1857 0.448148787839905 2614 25730
SGTC_2347 9049783 174.81 µM -0.130891365413094 0.452486672591739 no 1858 0.447930622659131 2738 6467988 YPL169C MEX67
SGTC_2674 ligustilide 100 µM -0.131336699673011 0.45232155113356 no 1859 0.447754480540751 2728 5319022 A signalling regulator.
SGTC_2442 5158906 48.48 µM -0.131601542655088 0.452223356310472 no 1860 0.44764973263886 2762 1893835
SGTC_975 1335-0046 28.5 µM -0.131886211267245 0.452117814072916 no 1861 0.447537147584101 2673 16486740
SGTC_3333 9141820 12.094 µM -0.132724641144271 0.451806981907722 no 1862 0.447205577227632 2685 1939433
SGTC_1484 3473-2379 286 µM -0.132814871160124 0.451773532577473 no 1863 0.447169896535563 2636 671917
SGTC_2682 pyrogallin 40.03 µM -0.133016358784947 0.451698839976592 no 1864 0.44709022151256 2664 822798 An ATP competetive kinase inhibitor.
SGTC_570 0987-0065 62.6 µM -0.134226162334644 0.451250395011761 no 1865 0.446611869276782 2621 3104428
SGTC_31 0508-1974 57.237 µM -0.134276464034986 0.451231750729121 no 1866 0.446591981831551 2672 6810525
SGTC_1382 3002-2117 298 µM -0.134358317145881 0.451201412172866 no 1867 0.446559620404315 2706 1497314
SGTC_3216 9129716 49.47 µM -0.13730803329115 0.450108302263566 no 1868 0.445393660466155 2693 8056934
SGTC_1877 wortmannin 25 µM -0.137785438157352 0.449931420265647 no 1869 0.445204996625189 2719 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1034 k072-0165 12.7 µM -0.137894888194496 0.449890869625931 no 1870 0.445161745222094 2776 5835461
SGTC_875 0709-0210 25.7 µM -0.138014092009488 0.449846705860152 no 1871 0.445114640158402 2630 6251364
SGTC_2106 5357045 167.29 µM -0.138952784790129 0.449498951758346 no 1872 0.444743729638252 2765 668842
SGTC_1085 doxorubicin 7.67 µM -0.141799476191776 0.448444586582573 no 1873 0.443619198913601 2714 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.141936007727681 0.448394026757027 no 1874 0.443565276088575 2643 88881 An O-methylated flavonoid and antioxidant.
SGTC_879 0831-1030 162 µM -0.142337089715053 0.448245504491758 no 1875 0.443406875701239 2670 1549252
SGTC_2603 homopterocarpin 100 µM -0.14369659185629 0.447742129496442 no 1876 0.442870031286493 2768 101795 A weak amylase inhibitor.
SGTC_2796 7949634 45.45 µM -0.144329146998739 0.447507945598023 no 1877 0.442620281641587 2647 2971588
SGTC_2795 7780010 54.55 µM -0.144865197026866 0.44730950404135 no 1878 0.442408652634151 2780 953673
SGTC_2383 9036125 200 µM -0.145102275164032 0.447221743760136 no 1879 0.442315060990514 2660 79580
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.145141637541438 0.447207173061732 no 1880 0.442299522165253 2781 521171
SGTC_2819 7996655 46.38 µM -0.146778456258126 0.446601338226202 no 1881 0.441653444953192 2756 6456960
SGTC_1540 guanosine 70.6 µM -0.147612215258667 0.446292787267862 no 1882 0.441324407166464 2646 6802 Guanosine is a purine nucleoside
SGTC_378 3970-0959 8.33 µM -0.147738683043015 0.446245987902775 no 1883 0.441274500975946 2778 6615653
SGTC_2279 7948423 32.93 µM -0.148282855456402 0.446044625617534 no 1884 0.441059772571629 2655 1247112
SGTC_2979 9012552 45.46 µM -0.148386698255783 0.446006201832342 no 1885 0.44101879855707 2734 17100905
SGTC_1039 k821-0043 94 µM -0.148667879143938 0.445902162171516 no 1886 0.440907854123428 2751 15992768
SGTC_1282 0886-0010 32.4 µM -0.150751110696133 0.445131462751592 no 1887 0.440086026703565 2765 2836211 YNL267W PIK1
SGTC_1516 st013856 110 µM -0.151959709690423 0.444684431816308 no 1888 0.439609356769603 2812 5281404 A mutagen and neurotoxin.
SGTC_2533 agelasine 13.65 µM -0.152164058918905 0.444608855017905 no 1889 0.439528770322016 2779 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1451 4152-0210 104 µM -0.153188059073502 0.444230167781793 no 1890 0.439124987004538 2747 659563
SGTC_728 3030-5151 22.5 µM -0.154227437804105 0.443845845429424 no 1891 0.438715204383668 2672 3125388
SGTC_1140 3229-1848 2.98 µM -0.155493092485381 0.443377926250838 no 1892 0.438216299555382 2780 2849525
SGTC_286 k060-0067 22.9 µM -0.155928736744299 0.443216884511585 no 1893 0.4380445968533 2702 5985051
SGTC_280 3448-3607 3.04 µM -0.156352672253852 0.443060180072465 no 1894 0.437877520177556 2706 626179
SGTC_958 1222-0007 33 µM -0.156621384851661 0.442960857176297 no 1895 0.437771623935349 2827 7312461
SGTC_1914 st062367 72.6 µM -0.1567451303524 0.442915118949541 no 1896 0.437722858894129 2708 978205
SGTC_2727 riluzole 51.77 µM -0.157436705851759 0.442659516106547 no 1897 0.437450343529565 2686 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2278 7948257 134.34 µM -0.157920019437193 0.442480899984994 no 1898 0.437259911389215 2749 1247028
SGTC_442 cape 100 µM -0.159450982879231 0.441915185757728 no 1899 0.436656787069389 2761 5281787
SGTC_907 3448-6986 75.5 µM -0.160125440537206 0.441666000934331 no 1900 0.436391130545641 2800 590582
SGTC_343 4130-2827 29.8 µM -0.160222355132591 0.441630196806097 no 1901 0.436352960015396 2732 1118244
SGTC_991 3996-0057 64.7 µM -0.160728346495576 0.441443271108509 no 1902 0.436153681207827 2778 715343
SGTC_1315 1237-0019 3.69 µM -0.164707542353428 0.439973715794653 no 1903 0.434587090063854 2784 825140
SGTC_1703 st026983 48.3 µM -0.165180810311354 0.439798987992211 no 1904 0.434400834467864 2805 1104023
SGTC_2714 st079313 56.9 µM -0.165793671052122 0.439572740766584 no 1905 0.434159663480821 2697 2939799
SGTC_2594 a-mangostin 100 µM -0.165863513923882 0.439546958418256 no 1906 0.434132180692338 2857 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2790 5423970 71.43 µM -0.166468295643392 0.43932371526082 no 1907 0.433894215717868 2845 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2005 4024620 188 µM -0.167089876890878 0.439094290999361 no 1908 0.433649665555777 2704 236743
SGTC_2357 9067248 200 µM -0.167161438202285 0.439067879189676 no 1909 0.433621512650442 2786 9150235
SGTC_1442 4112-3290 3 µM -0.168958286783881 0.43840478852661 no 1910 0.432914725967564 2704 704353
SGTC_2280 7785178 200 µM -0.168975757427714 0.4383983421841 no 1911 0.432907854975393 2718 2954328
SGTC_798 1287-0182 476 µM -0.171203240576102 0.437576576812433 no 1912 0.43203197975242 2798 1649755
SGTC_2303 7774051 200 µM -0.17237912902746 0.437142875168765 no 1913 0.431569739596068 2851 2953184
SGTC_2232 chlorophetanol 41.5365 µM -0.173142383998931 0.436861405066006 no 1914 0.431269755203389 2723 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2926 9010726 65.15 µM -0.173928575822008 0.436571509819296 no 1915 0.430960797318487 2820 2994293
SGTC_1468 k284-1086 134 µM -0.173966226515476 0.436557627601539 no 1916 0.430946002396832 2739 15996457
SGTC_1690 st023502 41.2 µM -0.17452091838194 0.436353115777349 no 1917 0.430728046266158 2808 24207482
SGTC_2045 5106652 78.05 µM -0.174610092196747 0.436320239470882 no 1918 0.430693008996259 2851 673349
SGTC_3021 9087658 49.47 µM -0.17611531682368 0.435765364808224 no 1919 0.43010167395879 2734 25237042
SGTC_477 mead ethanolamide 10 µM -0.177094013115306 0.435404653336506 no 1920 0.429717272221863 2696 16061185
SGTC_3255 9139072 49.47 µM -0.177960760653826 0.435085246920271 no 1921 0.429376896117819 2781 17646060
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.17831750121163 0.434953796221769 no 1922 0.429236817548387 2742 688669
SGTC_582 0987-0078 156 µM -0.178354287177331 0.434940241847292 no 1923 0.429222373592826 2734 1625765
SGTC_165 k038-0023 64.381 µM -0.18019863688214 0.434260760188749 no 1924 0.428498314263563 2746 46368543
SGTC_2848 9016370 25.97 µM -0.180866338262473 0.43401481835778 no 1925 0.428236245612225 2756 7894410
SGTC_1489 4065-0444 182 µM -0.180884500744213 0.434008128726493 no 1926 0.428229117392383 2738 2877968
SGTC_595 3909-8003 73.7 µM -0.181017051537949 0.433959308000715 no 1927 0.428177095959978 2830 699517
SGTC_2393 9031399 185.94 µM -0.18147376638978 0.433791099824591 no 1928 0.427997861326543 2868 1526623 YDL150W RPC53
SGTC_2699 st077704 54.6 µM -0.182055636421001 0.433576814341585 no 1929 0.427769531918463 2785 645852
SGTC_3029 9088683 49.47 µM -0.182953981449735 0.433246018858834 no 1930 0.427417063281466 2865 25236615
SGTC_2171 5739187 198.077 µM -0.184800202809911 0.432566336151889 no 1931 0.426692874389861 2687 2262761
SGTC_2692 st077426 47.7 µM -0.185009924846057 0.432489139982997 no 1932 0.426610625528966 2852 25238571
SGTC_1550 gossypolone 36.6 µM -0.185503393512305 0.432307510249301 no 1933 0.426417109410985 2741 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2499 avocadenofuran 51.48 µM -0.185846753288458 0.432181139143049 no 1934 0.426282469666365 2717 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2356 9061756 188.97 µM -0.186547879033633 0.431923116396573 no 1935 0.426007567856902 2805 20104043
SGTC_1113 artemisinin 1.17947 µM -0.187214210877152 0.431677925136254 no 1936 0.42574634157911 2823 2240 An anti-malaria and mitochondrial poison.
SGTC_1487 3970-0795 2.82 µM -0.187761603623898 0.43147651978502 no 1937 0.425531768120695 2817 3765103
SGTC_2747 doxorubicin 7.63 µM -0.189468712603477 0.430848528025666 no 1938 0.42486273733653 2727 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1322 1348-1070 12 µM -0.189738639496642 0.430749246367475 no 1939 0.424756970412507 2732 6758089
SGTC_2430 5571206 200 µM -0.189779876157005 0.430734079519927 no 1940 0.424740812904171 2877 1731771
SGTC_2226 7298446 200 µM -0.190245018008356 0.430563007384186 no 1941 0.424558567981962 2822 3283010
SGTC_415 dibenzyl ketone 100 µM -0.190297744453549 0.430543616217005 no 1942 0.424537910511837 2818 7593
SGTC_1131 3454-3128 32.3 µM -0.19058329599741 0.430438602039911 no 1943 0.424426039086994 2921 710982
SGTC_1332 1480-0653 17.5 µM -0.19077876761643 0.430366718410304 no 1944 0.424349462066748 2717 5749438
SGTC_1861 st057647 17.4 µM -0.190816211509302 0.430352948884699 no 1945 0.424334793553389 2927 688668
SGTC_1927 st060202 13.8 µM -0.191297192463534 0.430176081661429 no 1946 0.424146380282626 2709 688887
SGTC_25 0118-0223 35.662 µM -0.191892026693718 0.42995736747598 no 1947 0.423913391579634 2865 5333628
SGTC_3061 glucosamine 200 µM -0.193758667160725 0.429271163582173 no 1948 0.423182426219091 2751 91431 and experimental redox chemotherapeutic
SGTC_1421 4029-0249 71.4 µM -0.194509977271844 0.428995031368315 no 1949 0.422888292093124 2897 2894095
SGTC_2689 tacrolimus 100 µM -0.195157703629238 0.42875699762005 no 1950 0.422634744979968 2838 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_73 0327-0325 16.231 µM -0.196372695283138 0.428310568808972 no 1951 0.422159233089689 2921 53298
SGTC_3184 9108758 49.47 µM -0.196857406748284 0.428132495073966 no 1952 0.421969562938915 2716 902885
SGTC_2717 st081029 62.2815 µM -0.197118427709819 0.428036607017787 no 1953 0.421867431555126 2840 5292846
SGTC_1193 1488-0126 41.5 µM -0.197234819057684 0.427993851131208 no 1954 0.421821892042552 2776 1384710
SGTC_2519 cryptotanshinone 88.04 µM -0.197496206017377 0.427897834780328 no 1955 0.42171962506663 2869 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2285 7945142 200 µM -0.197824986080997 0.427777068705382 no 1956 0.421590998209235 2879 2970608
SGTC_216 k038-0035 28.382 µM -0.198027583196332 0.4277026549751 no 1957 0.421511741393537 2771 4444231 YPR107C YTH1
SGTC_1893 st059353 36.1 µM -0.199439951951581 0.427183964852638 no 1958 0.420959305512718 2809 3112488
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.200601832634851 0.426757360379613 no 1959 0.420504962483345 2895 61125 An anti-inflammatory.
SGTC_357 1325-0123 420 µM -0.200993428569188 0.426613598474219 no 1960 0.420351856230278 2883 1098503
SGTC_2175 5807670 165.306 µM -0.201171620865193 0.426548184106105 no 1961 0.420282190560314 2858 241186
SGTC_2913 7966556 36.57 µM -0.202118603021419 0.426200581024471 no 1962 0.419912002441392 2784 2976516
SGTC_2681 menadione 3.18 µM -0.202914642500369 0.425908427906117 no 1963 0.419600874650331 2820 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2305 7443522 69.23 µM -0.204795680850421 0.425218233020424 no 1964 0.418865880838989 2777 5415886
SGTC_1704 st028805 70.8 µM -0.20492551442059 0.425170602619802 no 1965 0.418815160300109 2814 2876101
SGTC_2165 5727197 32.143 µM -0.205071823320215 0.425116929432285 no 1966 0.418758005157173 3185 1361712
SGTC_935 2996-0153 430 µM -0.20675657157065 0.424498982468068 no 1967 0.418099987049278 2921 23738523
SGTC_3114 9122766 49.47 µM -0.208738734807154 0.423772184637141 no 1968 0.417326100073007 2818 17176985
SGTC_3176 9106582 49.47 µM -0.209207008061306 0.42360052110972 no 1969 0.417143320916419 2802 17018027
SGTC_1798 st045719 60.953 µM -0.210170981789086 0.423247185234969 no 1970 0.416767113461372 2780 3980186
SGTC_2128 5255449 168.493 µM -0.210287464100535 0.423204493868403 no 1971 0.416721659374735 2777 736008
SGTC_961 1252-1571 372 µM -0.21148717515552 0.422764846148517 no 1972 0.416253569321911 2936 6813498
SGTC_1411 3909-8223 150 µM -0.211924368634023 0.422604655524249 no 1973 0.416083019471469 2874 X1411
SGTC_2706 st078239 82.5 µM -0.212338945202246 0.422452763709861 no 1974 0.415921307108182 2767 15434492
SGTC_2367 9070478 135.38 µM -0.212540091179593 0.422379072362998 no 1975 0.415842851960792 2769 572802
SGTC_2846 9008642 19.48 µM -0.213183756404263 0.422143279019844 no 1976 0.415591818785095 2923 2992898
SGTC_794 k038-0031 316 µM -0.213866172538039 0.421893320563682 no 1977 0.415325710149036 2771 6624242
SGTC_2940 9060638 45.86 µM -0.214683875301678 0.421593850155611 no 1978 0.415006897555775 2897 4027022
SGTC_446 go6976 132 µM -0.214767792493302 0.421563119404329 no 1979 0.414974182402507 2925 3501 A protein kinase C inhibitor.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.214857286170293 0.421530347052179 no 1980 0.414939293903708 2775 66535 A nucleotide analog.
SGTC_2228 7354201 200 µM -0.215885169385259 0.42115397791566 no 1981 0.414538628819289 2802 753451
SGTC_1045 1348-1485 165 µM -0.216973597979624 0.420755518051262 no 1982 0.414114460286532 2785 6810614
SGTC_1781 st038725 66.3 µM -0.217696063122154 0.420491077547924 no 1983 0.413832965646973 2786 4270275 YIL048W NEO1
SGTC_380 3970-0968 6 µM -0.218204196426352 0.420305109399711 no 1984 0.413635007792863 2799 2891601
SGTC_513 4245-1575 41.7 µM -0.219125313545472 0.419968041577113 no 1985 0.413276216275242 2907 719745
SGTC_170 4197-0004 226 µM -0.219401460214874 0.419867001621623 no 1986 0.413168666326104 2939 218692
SGTC_2649 anisomycin 9.56 µM -0.220051381650155 0.41962922119199 no 1987 0.412915569257174 2844 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_253 dyclonine 31.25 µM -0.22109689731852 0.419246770152771 no 1988 0.412508493032061 2796 3180 An oral anasthetic.
SGTC_2224 6650123 117.647 µM -0.221176579987586 0.419217625249134 no 1989 0.412477472080035 2790 2908370
SGTC_983 1491-0821 12.2 µM -0.221649706846948 0.419044582490693 no 1990 0.412293292157071 2948 46495113
SGTC_1361 1608-0041 5.61 µM -0.224678388691594 0.417937236162421 no 1991 0.411114739059478 2812 X1361
SGTC_1731 st035964 63 µM -0.225122221947315 0.417775016315894 no 1992 0.410942097017905 2847 6739575
SGTC_3314 9135860 59.4275 µM -0.22532320237163 0.417701563118348 no 1993 0.410863925423237 2869 25252478
SGTC_868 0527-0199 213 µM -0.226765523866661 0.417174515941126 no 1994 0.41030303666089 2838 2849450
SGTC_843 0310-0051 143 µM -0.226948799586081 0.417107554718434 no 1995 0.410231777665518 2838 2065037
SGTC_1185 1319-0113 81.3 µM -0.227324767295273 0.416970199491919 no 1996 0.410085607835951 2911 4672763
SGTC_2824 7998404 51.95 µM -0.22816509547876 0.416663232481406 no 1997 0.40975894777142 2791 837851
SGTC_621 3584-0052 32.1 µM -0.228607179326399 0.416501762200947 no 1998 0.409587122016622 2854 2273927
SGTC_1101 ebselen 5.29 µM -0.22866672044916 0.416480015995593 no 1999 0.409563981356425 2966 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1831 st055328 12 µM -0.228692177939701 0.416470718233866 no 2000 0.409554087397661 2970 1103068
SGTC_1343 1487-0095 224 µM -0.229995887887105 0.4159946308143 no 2001 0.409047482532156 2868 4560101 YGL055W OLE1
SGTC_246 cycloheximide 667 µM -0.230256597548765 0.415899439901426 no 2002 0.408946192318299 2802 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.231611379722282 0.415404858269983 no 2003 0.408419934046275 2853 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_211 3455-0679 143.504 µM -0.231754726464859 0.415352535420584 no 2004 0.408364261373286 2886 748649
SGTC_899 1083-0020 478 µM -0.231871606259895 0.415309874355771 no 2005 0.408318869240289 2994 767123
SGTC_1567 st069303 68.4 µM -0.232175418133223 0.415198987850656 no 2006 0.40820088480869 2926 5581319
SGTC_96 0929-0093 37.281 µM -0.233019684064297 0.414890879695496 no 2007 0.407873060389571 2819 6991579
SGTC_1663 st014140 55.4 µM -0.2359530724142 0.413820770936483 no 2008 0.40673454242509 2850 4207120
SGTC_1814 st052110 31.539 µM -0.237198683246163 0.413366561424228 no 2009 0.406251328893936 2950 674163
SGTC_56 0957-0365 83.25 µM -0.23944271382855 0.412548573043981 no 2010 0.405381156116852 2927 6752360
SGTC_2469 5655019 90.81 µM -0.239445917212728 0.412547405624981 no 2011 0.405379914266504 2956 2788239
SGTC_2359 9039622 200 µM -0.239699053902357 0.412455156701187 no 2012 0.405281784220953 2809 6463596
SGTC_2589 lobaric acid 100 µM -0.240426061966494 0.412190244882466 no 2013 0.404999988053256 2856 73157 A novel microtubule depolymerizer.
SGTC_2639 lactacystin 53 µM -0.240519334453098 0.412156260554009 no 2014 0.404963838193112 2974 3870 A proteasome inhibitor.
SGTC_1560 lithocholic acid 53.1 µM -0.241314446387289 0.411866584042655 no 2015 0.404655707546482 2832 9903 A bile acid which acts as a detergent.
SGTC_912 3474-0017 2.18 µM -0.241679492245454 0.411733605999552 no 2016 0.404514260692971 3002 3360550
SGTC_2008 4012253 172 µM -0.244859103809457 0.410575774880695 no 2017 0.403282764146259 2821 603940
SGTC_2313 7726885 200 µM -0.245003503476216 0.410523211265189 no 2018 0.40322685932005 2948 726423
SGTC_1993 st073995 70.8 µM -0.245072534784849 0.410498083415068 no 2019 0.403200134310849 2869 3098394
SGTC_2988 9073640 71.4286 µM -0.246542485688391 0.409963098988102 no 2020 0.402631160164315 3038 9102229
SGTC_2909 7941780 10.49 µM -0.250422110662608 0.408551927750396 no 2021 0.401130466198567 2950 1243215
SGTC_1459 k035-0031 35.7 µM -0.250477150267287 0.408531916176387 no 2022 0.401109186532561 2812 3877128 YMR208W ERG12
SGTC_2004 4023728 41.89 µM -0.250911579395396 0.408373972641547 no 2023 0.400941235838739 2996 360084 YDR527W RBA50
SGTC_1840 st055363 71 µM -0.25175448474597 0.408067563633766 no 2024 0.400615420111606 2871 676033
SGTC_2651 TUB2.036 5 µM -0.25179581540143 0.408052540751526 no 2025 0.400599445980767 2966 15992207 YFL037W TUB2
SGTC_1774 st048371 48.465 µM -0.255301483254611 0.406778793392709 no 2026 0.399245127212067 2854 4242727
SGTC_1795 st049545 62.3 µM -0.255574494917912 0.406679638682016 no 2027 0.399139707283087 2926 5291882
SGTC_2441 5730946 39.09 µM -0.255624758109739 0.406661384318067 no 2028 0.399120299602028 2983 1774275
SGTC_2476 5806916 10.51 µM -0.256616175480023 0.406301367239645 no 2029 0.398737543419176 2853 2870194
SGTC_669 0108-0021 26.2 µM -0.257401902105306 0.406016099648776 no 2030 0.398434267338893 2947 17201
SGTC_1864 st057645 30.4 µM -0.257428132765649 0.406006577148837 no 2031 0.398424143841566 2894 688666
SGTC_562 3772-2733 112 µM -0.257514711340388 0.405975146978635 no 2032 0.398390730071915 2971 2876874 YIL048W NEO1
SGTC_1745 st081495 74 µM -0.258204758696845 0.405724664350927 no 2033 0.398124442757675 2854 13842402 YBL026W LSM2
SGTC_3329 9141233 27.5565 µM -0.259223795149623 0.405354831467041 no 2034 0.39773128628043 3032 4909101 YNL103W MET4
SGTC_634 1611-4317 11.2 µM -0.259978847015535 0.405080859424298 no 2035 0.39744004517499 2860 2843522
SGTC_1999 st074831 12.5 µM -0.259995099311985 0.40507496275771 no 2036 0.397433776913309 2891 17112523
SGTC_821 1114-0266 29.2 µM -0.260300883390638 0.404964022039101 no 2037 0.397315845619147 2931 3123235
SGTC_2418 pentamidine 31.67 µM -0.260617175129632 0.404849277099651 no 2038 0.397193871727091 2884 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_482 fipronil 114 µM -0.26113595008891 0.404661092616679 no 2039 0.396993834526832 2866 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2267 7931562 200 µM -0.261559259694688 0.404507554317061 no 2040 0.396830628394985 2823 934880
SGTC_396 dithiazanine 1.25 µM -0.264804870293382 0.403330831652394 no 2041 0.395579892421205 2891 10578 An antihelmenthic.
SGTC_1329 1447-1697 50.6 µM -0.264962521248037 0.403273696200515 no 2042 0.395519166950809 2984 2840515
SGTC_2568 diosmetin 100 µM -0.265079302010929 0.403231374149142 no 2043 0.395474185878765 3042 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1496 4469-0713 57.4 µM -0.265238432796622 0.403173706019213 no 2044 0.395412894863091 2997 746691
SGTC_2375 9072683 200 µM -0.265963806030689 0.402910861405251 no 2045 0.395133541979851 3041 16798029
SGTC_2718 lomofungin 53.02 µM -0.266570960478244 0.402690888007086 no 2046 0.394899758474662 3047 5351222 A RNA synthesis inhibitor.
SGTC_856 0433-0016 11.3 µM -0.269163119786555 0.40175209024565 no 2047 0.393902079706966 2952 3911780
SGTC_698 k064-0052 127 µM -0.270346440220334 0.401323717230895 no 2048 0.393446870419914 2866 5088751
SGTC_2444 5485484 36.41 µM -0.270528915649886 0.401257669966104 no 2049 0.393376687236624 3011 6790631
SGTC_1104 tacrolimus 29.8 µM -0.272649723211698 0.400490247802479 no 2050 0.392561242923221 2908 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_774 k060-0086 136 µM -0.273617123773822 0.400140317626793 no 2051 0.392189436579008 3026 5911235
SGTC_3168 9103419 49.47 µM -0.274487031613621 0.399825721164268 no 2052 0.391855184163782 2943 16649256
SGTC_2924 9010168 62.78 µM -0.275775590443201 0.399359841845137 no 2053 0.391360216482469 2984 2993929
SGTC_1502 4534-4282 27.7 µM -0.277426228334144 0.398763262003683 no 2054 0.390726422201907 2921 3278949
SGTC_2950 9072895 21.46 µM -0.277969606120827 0.398566923994797 no 2055 0.390517845216722 3028 17332245
SGTC_433 pimozide 108 µM -0.279847099292241 0.397888729636795 no 2056 0.389797407373109 2847 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_611 3453-1652 23.7 µM -0.28043256623133 0.397677308303433 no 2057 0.389572827369771 3003 1560575
SGTC_3208 9114115 49.47 µM -0.280717513442866 0.397574420245208 no 2058 0.389463537443221 2972 650895
SGTC_3146 9095609 49.47 µM -0.281434941393976 0.397315404642717 no 2059 0.389188410652039 2964 17173999
SGTC_1587 estradiol valerate 56.1 µM -0.281867951102952 0.397159095487145 no 2060 0.389022382420843 3058 13791 A steroid.
SGTC_627 1391-0720 175 µM -0.281936942745436 0.39713419220003 no 2061 0.388995930934646 2984 997839
SGTC_1897 st060201 15 µM -0.282988677064615 0.396754609192309 no 2062 0.388592758391135 2925 611878
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.283046735801686 0.396733657972068 no 2063 0.388570505606302 2910 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1222 0366-0074 1.18 µM -0.283221608221446 0.396670554877217 no 2064 0.388503482618367 3031 286520
SGTC_361 000s-0510 1.45 µM -0.286413477748845 0.395519238835978 no 2065 0.387280726573353 2999 660
SGTC_485 niflumic acid 177 µM -0.287265903925878 0.395211920145109 no 2066 0.386954363806499 3023 4488 A COX2 inhibitor.
SGTC_1509 1326-1131 80 µM -0.287893633145426 0.39498565138166 no 2067 0.386714080352561 3022 768313
SGTC_867 0518-0118 155 µM -0.28840979808913 0.394799623156822 no 2068 0.386516534223141 2999 6848158
SGTC_630 4356-0227 183 µM -0.288591919591343 0.394733991449601 no 2069 0.386446839880188 2931 779312
SGTC_79 0052-0007 94.094 µM -0.288709445825199 0.394691639731297 no 2070 0.386401866829649 3069 2801472
SGTC_364 0083-0097 67.7 µM -0.28948609049958 0.39441179959814 no 2071 0.386104711313479 3053 5207356
SGTC_945 3381-0768 11.3 µM -0.290950687191484 0.393884225380399 no 2072 0.385544517277655 3070 1126236 YIL048W NEO1
SGTC_2933 9026794 32.47 µM -0.292473664989287 0.393335827722021 no 2073 0.384962246172094 2963 17586027
SGTC_574 1315-0397 40 µM -0.292843557094709 0.39320266793599 no 2074 0.384820866598258 2913 6794277
SGTC_3312 9133330 71.43 µM -0.293003661203871 0.393145034923787 no 2075 0.384759676607202 3062 17617324
SGTC_2489 cantharidin 73.42 µM -0.293137009479697 0.393097035052521 no 2076 0.384708714585834 2897 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3181 9108277 49.47 µM -0.293239147983075 0.393060270509328 no 2077 0.384669681423148 2939 17097298
SGTC_1463 k081-0032 34.1 µM -0.293642690549514 0.392915025528149 no 2078 0.384515475380225 3000 977755
SGTC_608 k048-0125 159 µM -0.29465484798606 0.392550790587102 no 2079 0.384128779290742 3045 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_541 4513-1321 94 µM -0.294706717800164 0.392532127249373 no 2080 0.384108965462514 2938 747515
SGTC_1979 st071809 45.3 µM -0.294908273115433 0.392459607744913 no 2081 0.384031975920338 3056 4976333
SGTC_979 1426-2828 121 µM -0.295247587932035 0.392337530874466 no 2082 0.383902375722706 3060 747872
SGTC_1025 k007-0731 70 µM -0.296123958198542 0.392022284109252 no 2083 0.383567709033246 2928 6256118
SGTC_3273 9137859 49.47 µM -0.297254960284162 0.391615546289602 no 2084 0.383135932391846 2998 2377234
SGTC_1419 3993-2473 62.6 µM -0.298915111909612 0.391018727167596 no 2085 0.382502408168979 2960 704026
SGTC_1777 st045864 34.765 µM -0.299037456579963 0.390974754789044 no 2086 0.382455733094495 2993 4691462
SGTC_474 dl-dihydrosphingosine 5 µM -0.299384488340595 0.390850034326502 no 2087 0.382323348118307 3080 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_3126 9127922 49.47 µM -0.301259205801838 0.390176470182993 no 2088 0.38160842288576 3170 45595682
SGTC_3187 9109394 49.47 µM -0.301681220499964 0.390024890590716 no 2089 0.381447542771055 2976 17098090
SGTC_519 k048-0011 62.8 µM -0.301969594693382 0.389921321722045 no 2090 0.3813376207632 3048 6836379
SGTC_3186 9110464 49.47 µM -0.302141021223754 0.389859758016395 no 2091 0.381272281211728 3060 17018021
SGTC_521 r062-0005 13.8 µM -0.302661959296058 0.389672692627996 no 2092 0.381073745439344 2913 2832033
SGTC_2245 6637752 200 µM -0.302882322282766 0.38959356943801 no 2093 0.380989771869331 3065 681890
SGTC_3280 9140961 49.47 µM -0.30309758678729 0.389516281319484 no 2094 0.380907746585893 2910 4901226
SGTC_2074 5212007 75.395 µM -0.304237600392371 0.389107046128575 no 2095 0.380473440353644 3030 758611
SGTC_2512 diallyl trisulfide 49.23 µM -0.304903661960323 0.388868004262939 no 2096 0.380219763322762 2981 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_999 SEC7.066 22.7 µM -0.304959869677737 0.388847833880649 no 2097 0.380198358337656 2942 740511 YDR170C SEC7
SGTC_1853 st056710 91.2 µM -0.305084717515122 0.388803032766619 no 2098 0.380150815180926 3108 269167
SGTC_1274 0865-0114 173 µM -0.305335145376651 0.388713172255061 no 2099 0.380055455504091 2985 870624
SGTC_925 2064-1272 59.6 µM -0.305766701620298 0.388558331795194 no 2100 0.379891141604082 2957 6815817
SGTC_681 1642-0006 26.6 µM -0.305787162838251 0.3885509908407 no 2101 0.379883351587505 3031 4446530
SGTC_213 1246-0773 967 nM -0.306174935082065 0.388411875741679 no 2102 0.379735727746028 2978 6251622
SGTC_1277 0873-0036 22 µM -0.307080354852621 0.388087107936791 no 2103 0.379391105164871 3017 5965735
SGTC_2118 5526350 200 µM -0.30756311485977 0.38791397723304 no 2104 0.379207395283018 3050 743594
SGTC_3004 9076122 71.4286 µM -0.308328186204404 0.38763964774312 no 2105 0.378916310296823 3110 44782551
SGTC_3260 9137109 49.47 µM -0.308708578861081 0.387503272278589 no 2106 0.378771608696751 3017 17478346
SGTC_2760 etidronate 98.04 µM -0.310213306132609 0.386963945166583 no 2107 0.378199376246806 2977 3305 A chelator and antioxidant.
SGTC_1210 3013-0140 750 nM -0.310677370272909 0.386797658415829 no 2108 0.378022951207309 3075 905973
SGTC_540 1187-0821 17.3 µM -0.31156493502987 0.386479677823488 no 2109 0.377685593188897 2960 847520
SGTC_1821 st053465 65.6 µM -0.312086903431647 0.386292712033216 no 2110 0.377487239685868 3028 675086
SGTC_2683 piperine 63.03 µM -0.312514814684305 0.386139456610516 no 2111 0.377324652990883 2970 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1420 4'-methoxyflavone 42 µM -0.312760467959138 0.386051484484681 no 2112 0.377231325808717 3040 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1952 st077036 64.1 µM -0.313163413508574 0.385907196322508 no 2113 0.377078256577254 2911 2937007
SGTC_3008 9078912 71.4286 µM -0.313376083368553 0.385831049111463 no 2114 0.376997476246261 2980 16648731
SGTC_523 1934-0222 13.7 µM -0.314827207697191 0.385311586365226 no 2115 0.376446426328521 2969 1361595
SGTC_1729 st035615 45.989 µM -0.316153741885194 0.384836903411604 no 2116 0.375942908446348 3061 17385451
SGTC_3173 9105693 49.47 µM -0.316540025565277 0.384698709246252 no 2117 0.375796324861936 3114 17096658
SGTC_1583 clindamycin 39.6 µM -0.317236085885487 0.384449728533536 no 2118 0.375532235179343 2968 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_684 1140-0066 328 µM -0.318199106793118 0.384105334648073 no 2119 0.375166955129571 3030 6813534
SGTC_38 0929-0051 58.268 µM -0.319108404366481 0.38378023717696 no 2120 0.374822155407782 3097 1379719
SGTC_861 0443-0273 110 µM -0.32212864539892 0.382701010766269 no 2121 0.373677619027673 3071 6149169
SGTC_3346 9158254 43.5805 µM -0.323034769127372 0.382377401588154 no 2122 0.373334455249855 3061 17639500
SGTC_48 0382-0018 55 µM -0.326769640063385 0.381044414883147 no 2123 0.371921061837579 3242 762596
SGTC_882 0843-0131 351 µM -0.327795529875467 0.380678517946794 no 2124 0.371533133701274 3073 5425421
SGTC_2744 captopril 92.04 µM -0.329017704332173 0.380242752837868 no 2125 0.371071153123386 3076 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1863 st057641 20.1 µM -0.330670915666366 0.379653543831949 no 2126 0.370446536743309 3025 3921635
SGTC_2971 9092186 9.93 µM -0.331711166429774 0.379282938723791 no 2127 0.370053684034235 2934 25236400
SGTC_1391 3442-0225 151 µM -0.332562906477551 0.37897957598152 no 2128 0.369732123662838 2978 5227075
SGTC_1064 honokiol 6.76 µM -0.333359938117527 0.378695766131819 no 2129 0.369431300026953 3066 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_443 clozapine 122 µM -0.333479978167972 0.378653027508803 no 2130 0.369386000233505 3055 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3206 9114350 49.47 µM -0.333655269281138 0.378590620164269 no 2131 0.369319853475376 3102 17087243
SGTC_832 4083-0019 164 µM -0.334667192032006 0.378230416198211 no 2132 0.368938076318792 3128 1990758
SGTC_2326 6164455 177.58 µM -0.338086702512592 0.377013991993127 no 2133 0.367648925507379 3058 2888790
SGTC_696 1560-0013 611 µM -0.338549275910627 0.376849533908745 no 2134 0.367474650043906 3204 1650269
SGTC_2342 7990637 118.86 µM -0.340750154507926 0.376067365080175 no 2135 0.366645838959248 3119 2033102 YER133W GLC7
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.34096198650731 0.375992109035215 no 2136 0.366566099581412 3020 115019
SGTC_2875 9039966 71.43 µM -0.341278999874945 0.375879494765261 no 2137 0.366446777809474 3073 6463691
SGTC_1604 st002052 72.4 µM -0.341738556070995 0.375716263052514 no 2138 0.366273826765977 3132 6254834 YHR062C RPP1
SGTC_1019 4262-0212 3.4 µM -0.342060504048278 0.375601922232641 no 2139 0.366152679874325 3093 4677213
SGTC_2332 7982454 138.89 µM -0.34402307769116 0.374905144758076 no 2140 0.365414465351246 3096 2981748
SGTC_932 2857-0803 154 µM -0.344209856042018 0.374838853602092 no 2141 0.365344235319763 3236 674898
SGTC_1875 nocodazole 6 µM -0.344569516150616 0.374711213870699 no 2142 0.365209013197452 3139 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1520 flindersine 88 µM -0.344737443838556 0.37465162273363 no 2143 0.36514588283 3267 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1807 st050092 58.9 µM -0.346491010352423 0.37402952788214 no 2144 0.364486869502639 3022 5008496
SGTC_508 roscovitine 141 µM -0.348923724624564 0.373167042046696 no 2145 0.363573286767864 2997 160355 A CDKinase inhibitor.
SGTC_383 2324-0395 7.37 µM -0.354181667164021 0.371305084884972 no 2146 0.361601370871665 3157 3146421
SGTC_1289 0976-0073 69.1 µM -0.354635763623104 0.371144419483049 no 2147 0.361431239939311 3136 3391136
SGTC_2868 9035608 32.47 µM -0.35528251909879 0.370915627516793 no 2148 0.361188975042351 2989 6462614
SGTC_1758 st042942 75.2445 µM -0.355519924682119 0.370831655921905 no 2149 0.361100060434123 3088 669317
SGTC_1022 4477-0945 21.3 µM -0.356197484819165 0.370592033205932 no 2150 0.360846337704987 3018 4648966
SGTC_2210 7115885 190.385 µM -0.356712558176346 0.37040990837225 no 2151 0.360653501587187 3054 2927039
SGTC_2948 9070189 9.45 µM -0.356723305110803 0.370406108671928 no 2152 0.36064947846537 3159 6473636 YDL196W YDL196W
SGTC_1990 st072050 59.8 µM -0.359156450357032 0.369546168778359 no 2153 0.359739026798953 3014 17233948
SGTC_1976 st070609 63.5 µM -0.359338338934482 0.369481910539943 no 2154 0.359670998321192 2979 682556
SGTC_2179 6298986 200 µM -0.359501581730266 0.369424242653225 no 2155 0.359609947371946 3179 738374
SGTC_2958 9077254 16.72 µM -0.362074023854011 0.368515878818064 no 2156 0.358648357263631 3250 16457351
SGTC_1461 k072-0203 53.8 µM -0.36223930222274 0.368457541859211 no 2157 0.358586606034696 3098 5418714
SGTC_2472 5377652 49.4 µM -0.362466628066928 0.368377309461842 no 2158 0.358501678695797 3082 1610903
SGTC_2645 abamectin 100 µM -0.362917610753816 0.368218156593954 no 2159 0.358333215446122 3153 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_717 1532-0246 73.2 µM -0.363018838664486 0.368182436128873 no 2160 0.358295405846966 3102 9561992
SGTC_545 4218-0007 221 µM -0.363476402846113 0.368020988898473 no 2161 0.358124518558942 3167 2840508
SGTC_1293 1000-1278 195 µM -0.363594277783356 0.367979401607059 no 2162 0.358080500204074 3178 678847
SGTC_2891 9063876 19.48 µM -0.363595864162251 0.367978841929496 no 2163 0.358079907811201 3134 6472478
SGTC_1118 chelidonine 707.474 nM -0.363827320907954 0.367897186542908 no 2164 0.357993479835517 3157 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_296 1222-0039 74.9 µM -0.36427466058858 0.367739386959014 no 2165 0.357826459910701 3073 5984176
SGTC_1126 isoteolin 1.0172 µM -0.364529018197831 0.36764967197476 no 2166 0.357731504416336 3035 133323
SGTC_1137 ixabepilone 100 µM -0.364596299890072 0.367625942121251 no 2167 0.357706388627944 3006 154225 A novel microtubule stabilizer.
SGTC_1291 0993-0025 5.79 µM -0.364637189836769 0.36761152072664 no 2168 0.35769112499584 3157 4353356
SGTC_190 3970-0790 3.722 µM -0.365349250621912 0.367360415360096 no 2169 0.357425359399574 3132 2832352
SGTC_941 3237-0776 460 µM -0.365893147888127 0.367168650376701 no 2170 0.35722240477991 3220 760008
SGTC_2206 7254556 146.969 µM -0.367465369576384 0.366614509601425 no 2171 0.356635959406161 3094 4398905
SGTC_358 0075-0058 9.45 µM -0.368297788333095 0.366321230107586 no 2172 0.356325600732236 3256 1069125
SGTC_747 3448-8087 38.7 µM -0.368687024815189 0.366184120280663 no 2173 0.356180510590484 3087 5168703
SGTC_486 niguldipine 82 µM -0.369474420843403 0.365906809697632 no 2174 0.355887067861553 3053 1236 A calcium channel blocker.
SGTC_3028 9087778 49.47 µM -0.370234207828455 0.365639289056826 no 2175 0.355603995247841 3060 17217395
SGTC_1958 st076513 41.9 µM -0.374117369346408 0.364273052510787 no 2176 0.354158498311843 3038 732122 YGL099W LSG1
SGTC_1764 st044502 93.5 µM -0.374249382760619 0.364226635605813 no 2177 0.354109393432429 3185 8407
SGTC_1231 0242-0792 125 µM -0.374698033205091 0.364068901637844 no 2178 0.353942527574279 3049 3707635
SGTC_3338 9144300 39.5675 µM -0.374941245421906 0.363983404094371 no 2179 0.353852081757108 3117 4901274
SGTC_995 3931-2021 34.6 µM -0.375535828825994 0.36377441588687 no 2180 0.353631002675379 3158 730143
SGTC_127 0180-0333 59.125 µM -0.375743969251877 0.363701266850331 no 2181 0.353553623184116 3107 771601
SGTC_1676 st018489 23.4 µM -0.376937063636915 0.363282060740931 no 2182 0.353110188348704 3065 3696235
SGTC_2866 9034245 58.44 µM -0.377327197630111 0.363145018600597 no 2183 0.352965231313178 3105 6462273
SGTC_3103 9120822 49.47 µM -0.378134746697998 0.362861406989991 no 2184 0.352665248579597 3298 17141819
SGTC_260 nsc-65238 3.989 µM -0.378604541083122 0.362696449573348 no 2185 0.352490774744942 3184 3246252
SGTC_993 3909-8757 62.7 µM -0.379673002270988 0.362321379090098 no 2186 0.352094081590098 3082 4288324 YLR208W SEC13
SGTC_1198 1612-1005 86.7 µM -0.380472559096941 0.36204079066755 no 2187 0.351797331187164 3247 6998509
SGTC_249 wiskostatin 11.211 µM -0.381069351852162 0.361831406530372 no 2188 0.351575894191896 3185 2775510 A n-wasp and actin depolymerizer.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.381368990599782 0.361726294167598 no 2189 0.351464733702244 3068 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2153 5569715 200 µM -0.382314863513319 0.361394553296668 no 2190 0.351113915542618 3128 2054701
SGTC_2372 9071633 200 µM -0.383172421645916 0.361093876625469 no 2191 0.350795962387006 3212 21321366
SGTC_3286 9117135 37.221 µM -0.383707395734158 0.360906347684213 no 2192 0.350597665232225 3090 3438150
SGTC_1376 2910-0861 41.3 µM -0.383858692586426 0.360853318396057 no 2193 0.350541591887025 3088 1112859
SGTC_2580 diallyl disulphide 81.36 µM -0.386708642291512 0.359854916689624 no 2194 0.349485958690471 3063 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_3026 9090633 49.47 µM -0.387340822830593 0.359633578821386 no 2195 0.349251953710447 3077 25236842
SGTC_2621 lithochol-11-enic acid 100 µM -0.388445629990709 0.35924687886568 no 2196 0.348843141082361 3207 6708711
SGTC_1181 1222-0449 220 µM -0.389088929259845 0.359021780334067 no 2197 0.348605181343336 3258 658318
SGTC_2956 9076196 2.52 µM -0.389306392231494 0.358945698360524 no 2198 0.348524754125732 3229 16423868
SGTC_1447 4239-0816 81.9 µM -0.390328568510003 0.358588152994365 no 2199 0.34814680037498 3088 1341554
SGTC_1387 3342-1166 1.8 µM -0.392406334897304 0.357861756698387 no 2200 0.347379003036002 3144 3418228
SGTC_1264 0783-0040 158 µM -0.393134858939691 0.357607183143227 no 2201 0.347109939456992 3037 2855798
SGTC_2684 capsaicin 100 µM -0.393697067855642 0.357410769607239 no 2202 0.346902353207623 3206 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2085 5307070 144.047 µM -0.39437187265111 0.35717506940108 no 2203 0.346653253480692 3078 2840351
SGTC_1571 st070080 73.4 µM -0.394541314083959 0.357115894351315 no 2204 0.346590715703954 3246 4315245
SGTC_463 ikarugamyin 104 µM -0.39758407735756 0.356053838085616 no 2205 0.345468399727716 3177 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2253 7938677 135.83 µM -0.398096443934206 0.355875109495864 no 2206 0.345279547780511 3260 2301972
SGTC_1933 st074711 15.9 µM -0.398491635116728 0.355737276776601 no 2207 0.345133911534881 3138 17250958
SGTC_2099 5377090 177.372 µM -0.398787159418685 0.355634217675047 no 2208 0.345025019612472 3193 2243829
SGTC_2564 betulinic acid 100 µM -0.399762468120827 0.355294170179398 no 2209 0.344665738443117 3357 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2471 5466956 24.79 µM -0.400597192503678 0.355003229750909 no 2210 0.344358356501428 3084 724419
SGTC_793 0488-0545 106 µM -0.401461150343393 0.354702189111746 no 2211 0.344040317756893 3074 292548
SGTC_1977 st070720 65.3 µM -0.402113666289639 0.354474884181521 no 2212 0.343800187750792 3215 682188
SGTC_542 3381-0244 89.3 µM -0.40255943742028 0.354319628912253 no 2213 0.343636177362397 3264 1112843
SGTC_1873 rapamycin 2 nM -0.403591783438243 0.353960171561433 no 2214 0.343256464388938 3123 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2270 7924575 90.91 µM -0.405011751647519 0.353465958872655 no 2215 0.342734436402972 3249 1262135
SGTC_2217 6934799 96.0675 µM -0.407539095539962 0.352586941067761 no 2216 0.34180604299864 3199 675606
SGTC_2103 5378138 10 µM -0.408854000826091 0.352129923810746 no 2217 0.341323403926316 3204 244142
SGTC_1923 st058458 19.1 µM -0.409785038733597 0.351806455114668 no 2218 0.340981821096885 3321 3534982
SGTC_2068 5226020 147 µM -0.410537102453285 0.35154524535939 no 2219 0.340705996140294 3160 1810509
SGTC_604 1000-0114 314 µM -0.411420708005046 0.351238437520129 no 2220 0.340382036038977 3258 1572745
SGTC_3067 9117431 49.47 µM -0.411476880335778 0.351218936490596 no 2221 0.340361445314392 3135 17150885
SGTC_1940 st075990 51.1 µM -0.412031608599657 0.351026375668186 no 2222 0.340158127761565 3370 1084979
SGTC_985 1493-0307 8.71 µM -0.412160383268646 0.35098168004996 no 2223 0.340110936250019 3279 3278274
SGTC_3171 9103192 49.47 µM -0.412692048372223 0.350797169469915 no 2224 0.339916125699243 3238 13018434
SGTC_2601 securinine 100 µM -0.413717136511159 0.350441519291452 no 2225 0.339540637783105 3112 442872 A GABA receptor antagonist.
SGTC_929 2805-0021 398 µM -0.413820521444628 0.350405657578777 no 2226 0.339502776903264 3204 3098024
SGTC_1784 st039334 36.3 µM -0.413846474536584 0.350396655293345 no 2227 0.339493272804658 3342 3496984
SGTC_1545 lovastatin 49.4 µM -0.413990311716517 0.35034676436671 no 2228 0.339440601057068 3204 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1325 1431-0015 227 µM -0.414807310054001 0.350063431816174 no 2229 0.339141483902938 3122 1103340
SGTC_1416 3966-0321 25.3 µM -0.41573551452969 0.349741634575423 no 2230 0.338801775261646 3176 582530 YLR208W SEC13
SGTC_2242 6630449 61.2675 µM -0.416538020675859 0.349463502396345 no 2231 0.338508175920206 3251 691249 YDR170C SEC7
SGTC_883 0850-0245 24.6 µM -0.416611797117814 0.349437937047362 no 2232 0.33848118950483 3320 6823229 YPR165W RHO1
SGTC_2132 5317594 122.667 µM -0.418185060423238 0.348892925414186 no 2233 0.337905908895997 3095 794577
SGTC_2679 rapamycin 1 nM -0.418647258377935 0.348732869452354 no 2234 0.337736973107853 3209 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_365 0121-0052 13.6 µM -0.419204608934399 0.348539898604122 no 2235 0.3375333020167 3256 3101739
SGTC_195 4234-0266 16.654 µM -0.420086804645664 0.348234537106801 no 2236 0.337211020929388 3155 2303354
SGTC_820 1582-0060 59.9 µM -0.423097295150943 0.34719323336474 no 2237 0.33611213788243 3149 3848840
SGTC_2459 5811157 9.22 µM -0.423428004492709 0.347078913861276 no 2238 0.335991508161549 3209 2870684 YBR192W RIM2
SGTC_1474 0330-0125 5.35 µM -0.423922249641301 0.34690808929133 no 2239 0.335811258518094 3239 X1474
SGTC_3036 9090181 49.47 µM -0.427448920015253 0.34569008089096 no 2240 0.334526191176494 3167 25236586
SGTC_2384 9036245 200 µM -0.429809743927782 0.344875612292125 no 2241 0.333667022146714 3182 6462766
SGTC_2952 9073731 13.78 µM -0.430624143072782 0.344594816424961 no 2242 0.333370841745872 3165 16457353
SGTC_1930 st074634 34.3 µM -0.431100403906787 0.344430646587055 no 2243 0.333197683484059 3120 684253 YOR116C RPO31
SGTC_732 3970-1727 52.7 µM -0.431623201335356 0.344250469056851 no 2244 0.33300764644068 3254 1275699
SGTC_1435 4092-0789 56.7 µM -0.43289274249898 0.343813080075162 no 2245 0.332546346362181 3253 2248285
SGTC_677 0929-0063 136 µM -0.435826795009662 0.342803025242678 no 2246 0.33148120071441 3230 1539583
SGTC_2844 9010103 25.97 µM -0.442986165964872 0.340343117733395 no 2247 0.328887870523971 3318 2480525
SGTC_2616 abietic acid 100 µM -0.443229421325934 0.340259655458848 no 2248 0.328799900073626 3334 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_965 1291-5240 308 µM -0.443527345840725 0.340157446552819 no 2249 0.328692172086031 3298 2834598
SGTC_1327 1436-0082 2.18 µM -0.445893555294979 0.33934608911633 no 2250 0.327837068893583 3198 15992205
SGTC_2095 5432005 200 µM -0.44750594570848 0.338793637288429 no 2251 0.327254897944076 3170 783734
SGTC_181 1447-1644 8.07 µM -0.449073423630772 0.338256905993264 no 2252 0.326689345657512 3263 534600
SGTC_3172 9105863 49.47 µM -0.449362180146509 0.338158066616373 no 2253 0.326585204530042 3236 2348785
SGTC_1240 0356-0016 42.1 µM -0.449836088408065 0.337995875241552 no 2254 0.326414317015475 3205 4305613
SGTC_2415 st077333 57.7 µM -0.451438631254174 0.337447640464024 no 2255 0.325836722962193 3404 2766255
SGTC_128 0906-2981 13.371 µM -0.45357538774347 0.336717186186547 no 2256 0.325067235763147 3339 6740226
SGTC_1780 st038448 24.544 µM -0.453967869320488 0.336583082449077 no 2257 0.324925976532888 3353 728868 YDL195W SEC31
SGTC_2058 5236698 133 µM -0.454498124891419 0.336401936876748 no 2258 0.324735170619852 3205 766665
SGTC_111 0083-0039 52.457 µM -0.455518476290084 0.336053471930629 no 2259 0.324368139180191 3153 759313
SGTC_802 4112-3352 742 µM -0.457271653233585 0.335455065377377 no 2260 0.323737900909583 3335 704594
SGTC_2813 7971799 71.43 µM -0.458371705235266 0.335079800869636 no 2261 0.323342708083186 3278 2234054
SGTC_3015 9080845 49.47 µM -0.458633631552917 0.334990473290277 no 2262 0.323248640607619 3340 5296973
SGTC_2540 epiandrosterone 100 µM -0.461891033945658 0.333880347144167 no 2263 0.322079732026752 3291 441302 A steroid.
SGTC_209 4077-0173 175.592 µM -0.462185927590876 0.333779918628476 no 2264 0.32197399697517 3258 15993494
SGTC_3313 9133968 57.047 µM -0.463263728262577 0.333412965854987 no 2265 0.321587670762045 3295 1494643
SGTC_2738 aclarubicin 5.55 µM -0.463331127193864 0.333390024208125 no 2266 0.321563518733486 3232 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1756 st041558 35.5 µM -0.467225173817761 0.332065606127458 no 2267 0.320169392346471 3390 3955792
SGTC_1042 0350-0096 82 µM -0.467499179741594 0.331972491708455 no 2268 0.320071389405494 3213 3122515
SGTC_3001 9076041 71.4286 µM -0.468061854054299 0.331781312715518 no 2269 0.319870178603259 3229 16004211
SGTC_2480 5767542 37.17 µM -0.469405583106393 0.331324933212578 no 2270 0.319389879202401 3219 2867358
SGTC_2478 5763493 32.33 µM -0.471870970265413 0.330488249113661 no 2271 0.318509444986865 3218 1365576 YLR208W SEC13
SGTC_1432 4049-0298 68.4 µM -0.471975350219292 0.330452844099824 no 2272 0.318472191580891 3322 741646
SGTC_52 0329-0193 875 nM -0.472833582907011 0.330161794609241 no 2273 0.318165956295357 3412 3739292
SGTC_964 1287-0107 19.4 µM -0.473797350787327 0.329835077806045 no 2274 0.317822211967265 3359 51516812 YPR165W RHO1
SGTC_2406 ethylparaben 405.7 µM -0.473838336842828 0.329821186430115 no 2275 0.317807597065291 3088 8434 A possible steroid mimic.
SGTC_338 4055-0136 114 µM -0.474525135563532 0.329588445139515 no 2276 0.317562739038911 3219 2900563
SGTC_2593 nobiletin 86.24 µM -0.475595860144208 0.329225731297774 no 2277 0.317181162648384 3276 72344 An anti-infammatory.
SGTC_255 tunicamycin 200.472 nM -0.478105975440892 0.328376046279904 no 2278 0.316287389645591 3280 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1860 st056228 74.6 µM -0.478688768165028 0.32817889509958 no 2279 0.316080028689667 3327 688679
SGTC_2159 5658611 73.75 µM -0.478860057113582 0.328120959377928 no 2280 0.316019094106304 3362 793844
SGTC_3257 9139206 32.98 µM -0.479394450378458 0.327940236060187 no 2281 0.315829020383059 3326 4910041
SGTC_2145 5634607 200 µM -0.480176916673548 0.327675691060766 no 2282 0.315550799554912 3221 308662
SGTC_1645 Cervolide 78 µM -0.480930781249973 0.327420897838645 no 2283 0.315282847465757 3303 23173 A fragrance.
SGTC_2936 9038235 15.59 µM -0.482643330638412 0.326842384503221 no 2284 0.314674503534156 3263 4749415
SGTC_2178 5812956 200 µM -0.482793220971831 0.326791770087947 no 2285 0.31462128232872 3275 5403383
SGTC_1700 st030840 7.9285 µM -0.482878847866446 0.326762857344115 no 2286 0.314590880718593 3325 5499307
SGTC_1074 carmofur 3.8 µM -0.485068167183869 0.326023966358667 no 2287 0.313813995903384 3316 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2641 levomentholum 100 µM -0.485252466757047 0.325961796723865 no 2288 0.313748634380652 3306 16666
SGTC_1842 st055362 61.2 µM -0.485933307554955 0.32573217117551 no 2289 0.313507226071707 3236 676032
SGTC_1563 conessine 56.1 µM -0.486510132244324 0.325537678611249 no 2290 0.313302761633339 3349 441082 An anti-amoebic, histamine inhibitor.
SGTC_2143 5623677 140.463 µM -0.488533838924709 0.324855705220235 no 2291 0.312585881540096 3326 5375313
SGTC_2897 9048598 12.99 µM -0.490031204781996 0.324351481991145 no 2292 0.312055908863911 3243 6467404
SGTC_1065 prochlorperazine maleate 2.48 µM -0.49008254040688 0.32433420092634 no 2293 0.312037746190967 3375 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1225 1216-0074 20.6 µM -0.490305991891091 0.324258985064093 no 2294 0.31195869381865 3267 4241466
SGTC_1591 genipin 88.4 µM -0.490528570100719 0.324184070283271 no 2295 0.311879959002032 3369 442424 A DNA cross-linking agent.
SGTC_2156 5649887 115 µM -0.490684098838295 0.324131727059382 no 2296 0.311824947367466 3366 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2991 9074669 71.4286 µM -0.490988040997183 0.324029445307937 no 2297 0.31171745295635 3402 17333109
SGTC_1867 st057372 64 µM -0.491042559835416 0.324011100188185 no 2298 0.311698173120952 3341 688837
SGTC_3083 9117465 49.47 µM -0.491363429034556 0.323903139125938 no 2299 0.311584712612475 3326 16420915
SGTC_3054 9094397 49.47 µM -0.491755076982642 0.323771383608625 no 2300 0.311446248724223 3290 2598354
SGTC_1581 himbacine 57.9 µM -0.492314927317975 0.323583080943898 no 2301 0.311248364580861 3259 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_305 1682-2595 20.8 µM -0.492577646210617 0.323494732416642 no 2302 0.31115552301911 3330 226033
SGTC_2361 9034121 116 µM -0.493313682257938 0.323247267238917 no 2303 0.310895481103832 3273 6496917
SGTC_2078 5212016 200 µM -0.49408042971376 0.322989559622861 no 2304 0.310624689227563 3309 1899708
SGTC_817 1391-0715 46 µM -0.495240637897028 0.322599769468359 no 2305 0.31021513404961 3278 1353946
SGTC_3046 9092212 49.47 µM -0.495324459223562 0.322571615921316 no 2306 0.310185554106516 3329 25236637
SGTC_516 3992-2719 87.3 µM -0.497352101526715 0.321890890396503 no 2307 0.309470388263947 3168 5350887 YDR037W KRS1
SGTC_2680 butyl paraben 22.24 µM -0.497705804375729 0.321772205445077 no 2308 0.309345708185458 3351 7184 An antifungal and steroid mimetic.
SGTC_1744 st037937 38.9 µM -0.499550682152972 0.321153451901617 no 2309 0.30869574572594 3419 1016152
SGTC_1811 st050069 61.5 µM -0.500413395132533 0.320864276757751 no 2310 0.308392011678276 3378 3877702
SGTC_1273 0849-0096 14.1 µM -0.500620025826959 0.320795031765589 no 2311 0.3083192829774 3322 5286025
SGTC_2769 toremifene 3.73 µM -0.501438079324184 0.320520951193848 no 2312 0.308031423013725 3449 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1617 st002906 78 µM -0.501936958309582 0.320353854840015 no 2313 0.307855933405655 3340 5150859
SGTC_320 4092-0846 5.34 µM -0.502043677890456 0.320318114519972 no 2314 0.307818398587681 3331 1359356
SGTC_759 3486-0358 89.3 µM -0.503648495585679 0.319780863221071 no 2315 0.307254203700348 3431 875103
SGTC_693 4161-2696 114 µM -0.50411915505202 0.319623370263274 no 2316 0.30708882353827 3359 805759
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.504841714484298 0.319381649361512 no 2317 0.306835007214198 3334 6312947
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.505729482057827 0.319084765741654 no 2318 0.306523284317475 3429 23847180
SGTC_2723 salbutamol 83.58 µM -0.506413199366361 0.318856198842444 no 2319 0.306283305204103 3356 9884233 β2-adrenoceptor agonist
SGTC_2055 5235184 200 µM -0.507313873195901 0.318555208452195 no 2320 0.305967302964109 3398 2836034
SGTC_2202 7226349 200 µM -0.508719100951711 0.318085843536756 no 2321 0.305474565895395 3274 844334
SGTC_1879 gemcitabine 100 µM -0.509152644797918 0.317941092985569 no 2322 0.305322616652706 3328 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2121 5257820 149.641 µM -0.510332700595282 0.317547239785592 no 2323 0.304909198469874 3415 791256
SGTC_3201 9113999 49.47 µM -0.512778787329107 0.316731496288931 no 2324 0.304053034922239 3398 16649224
SGTC_2954 9074818 52.69 µM -0.512869915072736 0.316701123350404 no 2325 0.304021159687838 3399 16648742
SGTC_3094 9117742 49.47 µM -0.513136299346354 0.316612344378238 no 2326 0.30392799066676 3342 17149698
SGTC_2390 9097792 176.6 µM -0.513368117653717 0.316535093942521 no 2327 0.303846921600818 3318 4497149
SGTC_3271 9137798 49.47 µM -0.513597510253035 0.316458659719872 no 2328 0.30376671032444 3364 6498326
SGTC_328 k915-0120 63.5 µM -0.514139453452354 0.31627811394835 no 2329 0.303577247610091 3372 6624543
SGTC_2962 9082311 13.18 µM -0.514343327980772 0.316210205462012 no 2330 0.303505986972366 3265 16459453
SGTC_2214 7179297 48.276 µM -0.514365636145251 0.316202775220504 no 2331 0.303498190012229 3360 769744
SGTC_1500 4488-1866 171 µM -0.515223222019565 0.315917193034494 no 2332 0.303198521737738 3458 2900003
SGTC_2168 5727979 200 µM -0.515241971576208 0.315910950525296 no 2333 0.303191971513664 3343 695210
SGTC_1357 1503-1303 39.5 µM -0.516460609162555 0.315505327921228 no 2334 0.302766371944506 3342 292895
SGTC_2937 9044753 11.33 µM -0.517806581637713 0.315057580229281 no 2335 0.302296612898871 3330 6465530 YGL099W LSG1
SGTC_1730 st033808 45.1 µM -0.518992511691544 0.314663296879311 no 2336 0.301882981605934 3266 1045166
SGTC_596 1155-0152 116 µM -0.520267891179076 0.314239510207945 no 2337 0.301438435980187 3370 280313
SGTC_1406 3909-7906 11.9 µM -0.520382232984501 0.314201528339793 no 2338 0.301398595454127 3389 X1406
SGTC_2715 st079500 56.4 µM -0.52115339597901 0.313945416114201 no 2339 0.301129958286933 3325 28246688
SGTC_3214 9129694 49.47 µM -0.521166454728111 0.313941079922455 no 2340 0.301125410157789 3418 17158655
SGTC_1661 st013063 9.66 µM -0.522304077395803 0.313563428009627 no 2341 0.300729315361029 3350 721395
SGTC_758 0868-0029 16 µM -0.522901899315556 0.313365049793268 no 2342 0.300521261409006 3417 762687
SGTC_1681 tripelennamine 100 µM -0.52306629203789 0.313310508001109 no 2343 0.300464060859939 3405 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1347 1493-0251 600 nM -0.525215080369631 0.312597964413439 no 2344 0.299716841352903 3424 3986378
SGTC_671 0560-0003 407 µM -0.525805802681863 0.31240220195681 no 2345 0.299511571208271 3317 3238678
SGTC_2880 9042983 58.44 µM -0.52585707953778 0.312385211556155 no 2346 0.299493756015617 3426 6464714
SGTC_1372 2752-0194 270 µM -0.52614050618346 0.312291306359018 no 2347 0.299395293350339 3395 823334
SGTC_2324 6149169 200 µM -0.526703832666042 0.312104700670922 no 2348 0.299199636831871 3311 2888231
SGTC_1426 4048-4480 71.7 µM -0.527020167183612 0.311999933863468 no 2349 0.299089791870021 3416 14224343
SGTC_2386 9075165 157.42 µM -0.528517631274536 0.311504195316294 no 2350 0.298570056517667 3390 16452277
SGTC_3207 9114163 49.47 µM -0.528916398675981 0.31137224009918 no 2351 0.298431722813235 3528 849233
SGTC_2556 citropten 84.59 µM -0.529005531894208 0.311342748540693 no 2352 0.298400806199531 3333 2775 A potential DNA crosslinker.
SGTC_2845 9003024 42.97 µM -0.52908206135614 0.311317428160232 no 2353 0.298374262468851 3504 2990173
SGTC_1339 1486-1321 22.7 µM -0.53164999453867 0.310468325182794 no 2354 0.297484215840528 3349 3469382
SGTC_1620 st003704 16.5 µM -0.532385932285543 0.310225168630087 no 2355 0.297229363218304 3432 2834414
SGTC_1986 st071812 45 µM -0.532863761018395 0.31006733665163 no 2356 0.297063946275089 3411 11838594
SGTC_1168 k815-0004 80.5 µM -0.533659368369348 0.309804616611393 no 2357 0.296788612721124 3311 642433
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.535169834829292 0.309306107943703 no 2358 0.296266211606481 3419 279621
SGTC_458 nppb 133 µM -0.537063408658062 0.30868165554581 no 2359 0.2956119076024 3505 4549 A chloride channel blocker.
SGTC_41 0478-0632 82.643 µM -0.540712201661338 0.307479936583861 no 2360 0.294352983500577 3461 3750424
SGTC_2990 9074105 71.4286 µM -0.544314416042312 0.306295581612801 no 2361 0.293112564157551 3408 6502001
SGTC_1128 3448-9350 235 µM -0.544807555498963 0.306133601646241 no 2362 0.292942940851168 3362 619386
SGTC_1218 1348-1416 30.7 µM -0.545396859369977 0.305940084557083 no 2363 0.292740299999406 3408 6787668
SGTC_1441 4106-0040 13 µM -0.546704442784127 0.305510890486069 no 2364 0.292290900722557 3425 2904180
SGTC_2626 ethyl orsellinate 100 µM -0.54731683890991 0.305309972726043 no 2365 0.292080538592861 3355 75653 A natural product.
SGTC_1012 4112-3522 18 µM -0.547362848503195 0.305294880053011 no 2366 0.292064736838982 3460 3112398
SGTC_2728 chlorpromazine 9.18 µM -0.548135236547663 0.305041560586599 no 2367 0.291799523643282 3401 2726 A thorazine and dopamine antagonist.
SGTC_1934 st074720 32.6 µM -0.548490823886857 0.304924970287526 no 2368 0.291677464125982 3402 17250992
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.548979629799609 0.304764732482794 no 2369 0.291509714626942 3436 3256 An antibiotic and ribosome inhibitor.
SGTC_1602 st001878 87.6 µM -0.55135829541478 0.303985505621672 no 2370 0.290694041820355 3479 595405 YLR310C CDC25
SGTC_215 1287-0124 461.5 µM -0.552993328584761 0.303450400934473 no 2371 0.290133989226865 3399 5560863
SGTC_1221 2958-7315 257 µM -0.55556814515552 0.302608583382338 no 2372 0.28925305648181 3449 4562705
SGTC_906 1165-0455 526 µM -0.558070749143363 0.301791379645353 no 2373 0.288398036873565 3442 3252859
SGTC_91 0417-1751 58.384 µM -0.55822767142158 0.30174017109532 no 2374 0.288344463786489 3496 6795624
SGTC_366 0181-0206 4.31 µM -0.560161492847604 0.301109426864152 no 2375 0.287684644884069 3528 274874
SGTC_1644 st010134 20.9 µM -0.561250901552608 0.300754362068631 no 2376 0.287313253641674 3456 3818134
SGTC_398 bronopol 33.3 µM -0.561315157995688 0.300733425232209 no 2377 0.287291355010157 3375 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_3309 9129340 25.759 µM -0.562181537585687 0.300451194861494 no 2378 0.286996169507752 3404 17158987
SGTC_2266 7929956 200 µM -0.562232458200848 0.300434610770077 no 2379 0.286978824738671 3472 2967153
SGTC_29 0299-0004 12.984 µM -0.566201053610043 0.299143372158406 no 2380 0.285628556893599 3374 16871 A napthoquinone isolated from Swertia calycina.
SGTC_565 1418-0001 44.5 µM -0.567473463081871 0.298729909661069 no 2381 0.285196275484466 3514 2862145
SGTC_97 0535-0701 19.132 µM -0.571023402292451 0.297577752074125 no 2382 0.283991889714686 3460 2832013 YGL099W LSG1
SGTC_887 0885-0007 9.62 µM -0.57302677420439 0.296928440371669 no 2383 0.283313282828879 3493 5719458
SGTC_1686 st019653 115.5 µM -0.573069389739588 0.296914635319194 no 2384 0.283298856018932 3494 97252
SGTC_1349 flufenamic acid 69 µM -0.573798255021503 0.296678569168785 no 2385 0.283052164857902 3447 3371 A non-steroidal anti-inflammatory.
SGTC_1040 k898-0338 155 µM -0.573877865365033 0.296652790040312 no 2386 0.283025226251627 3537 20969351
SGTC_799 1310-0557 151 µM -0.574620557426147 0.296412343674613 no 2387 0.282773972880076 3516 5354492
SGTC_370 0180-0345 38.7 µM -0.574809451113809 0.296351203644123 no 2388 0.282710087077462 3407 3989527
SGTC_104 0074-0074 590.992 µM -0.575355136741558 0.296174611722186 no 2389 0.282525569510531 3383 3943124
SGTC_2853 9015042 58.44 µM -0.577628476251631 0.295439445544248 no 2390 0.281757488583947 3394 6457456
SGTC_2992 9074591 71.4286 µM -0.577887451605575 0.295355749823993 no 2391 0.281670053883763 3493 17741321
SGTC_2455 5377712 9.75 µM -0.578217894457611 0.295248973063385 no 2392 0.281558509480402 3454 2243908
SGTC_2529 gangaleoidin 93.61 µM -0.578973411119473 0.295004908000948 no 2393 0.281303557090409 3459 4565183
SGTC_526 4469-0568 170 µM -0.579101540104651 0.294963525931365 no 2394 0.281260330461274 3501 2901964
SGTC_543 3844-1095 191 µM -0.57938297165283 0.294872640823018 no 2395 0.281165395701259 3462 4230703
SGTC_228 caffeine 993.056 µM -0.579501204081624 0.294834462859354 no 2396 0.281125517201622 3506 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2043 5101342 149 µM -0.579970001320115 0.29468310783981 no 2397 0.280967423939758 3420 678451
SGTC_2124 5246320 200 µM -0.580257023038846 0.294590458222815 no 2398 0.280870652344972 3471 579342
SGTC_2762 leflunomide 42.06 µM -0.580726460812562 0.294438954307585 no 2399 0.280712412500976 3482 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3163 9099914 49.47 µM -0.583296454382432 0.293610166071015 no 2400 0.279846874489371 3509 16268368
SGTC_1907 st060210 83.7 µM -0.584669399631407 0.293167852825718 no 2401 0.279385016753076 3555 688793
SGTC_587 k089-0003 57 µM -0.585020534994872 0.293054779360463 no 2402 0.279266954571812 3470 9659696
SGTC_648 0375-0473 33.3 µM -0.585480359096087 0.292906736283244 no 2403 0.279112384668009 3492 1713139
SGTC_2424 5537928 59.2 µM -0.586013240564012 0.292735215389529 no 2404 0.278933308575188 3457 5382802
SGTC_2833 9001315 45.46 µM -0.587420149870389 0.292282591613619 no 2405 0.278460782104181 3363 2989378
SGTC_1753 st043925 64 µM -0.587973604836531 0.292104626126087 no 2406 0.278275004917331 3489 670181
SGTC_3066 9117245 49.47 µM -0.588548526137228 0.291919811481916 no 2407 0.278082086174186 3463 17176980
SGTC_1450 4112-4260 37.6 µM -0.588931723113919 0.291796658939375 no 2408 0.277953538074354 3524 1633175
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.589229515025109 0.291700970750764 no 2409 0.2778536601749 3487 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1433 4060-0023 7.6 µM -0.590085195085371 0.291426100191693 no 2410 0.277566766954088 3506 3840627
SGTC_624 k048-0052 28 µM -0.590113189593267 0.291417109542714 no 2411 0.27755738337475 3452 6835531
SGTC_1355 1499-0035 1.68 µM -0.59057110170836 0.291270065959526 no 2412 0.277403916182349 3495 1548538
SGTC_3131 9127911 49.47 µM -0.591095537569387 0.2911017029961 no 2413 0.277228204833033 3574 45595681
SGTC_1249 0481-0015 10.2 µM -0.591985906358315 0.290815966405684 no 2414 0.276930013010579 3435 4227577
SGTC_2265 7929201 200 µM -0.592775732823084 0.290562605595712 no 2415 0.276665625151358 3462 1265108
SGTC_1056 3448-1962 115 µM -0.593011581324036 0.290486970061226 no 2416 0.276586700811143 3478 715507
SGTC_101 0490-5701 117.494 µM -0.593932412575262 0.290191751955762 no 2417 0.276278659551349 3465 4661669
SGTC_459 nigericin 15.3 µM -0.593998045647263 0.290170715388638 no 2418 0.276256710062872 3551 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2223 6903751 107.57 µM -0.594647718775942 0.289962522146095 no 2419 0.276039487824657 3482 5598863
SGTC_1321 1326-2144 215 µM -0.595138610931168 0.289805258078012 no 2420 0.275875410635603 3492 3513030
SGTC_1507 4075-3230 155 µM -0.596178973974668 0.289472095770907 no 2421 0.275527835190137 3459 659771
SGTC_716 1683-5115 658 µM -0.597200808503302 0.289145042190833 no 2422 0.275186659735761 3557 723597
SGTC_2876 9059903 25.97 µM -0.597887113624571 0.288925477450187 no 2423 0.274957629421036 3510 6916095
SGTC_2139 5578692 56.4705 µM -0.599747872218353 0.288330573181802 no 2424 0.274337139284189 3469 650991 YMR113W FOL3
SGTC_2309 7664088 163.95 µM -0.600255334936786 0.288168432258969 no 2425 0.274168040385217 3537 704922
SGTC_2785 7756463 72.73 µM -0.60143606616613 0.287791339887043 no 2426 0.273774791438645 3457 2201551
SGTC_2438 5259590 200 µM -0.602799905121057 0.287356058404843 no 2427 0.273320904947956 3487 1201127
SGTC_3316 9136639 10.545 µM -0.603131592627525 0.287250244454639 no 2428 0.273210575497174 3518 4903665
SGTC_173 1273-0061 2.693 µM -0.604243024686391 0.286895813228461 no 2429 0.272841039980499 3477 2847414 YPL266W DIM1
SGTC_2110 5483698 200 µM -0.604284703777664 0.286882525965423 no 2430 0.27282718709358 3492 2848765 YHR062C RPP1
SGTC_2029 5175081 200 µM -0.606405994618904 0.286206645445704 no 2431 0.272122594381961 3517 1380876
SGTC_475 α-linolenic acid 10 µM -0.607133841887282 0.285974914903495 no 2432 0.271881046477398 3627 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1963 st076565 50.3 µM -0.609376388544514 0.285261498651319 no 2433 0.271137492329368 3542 4914280
SGTC_2284 7945075 39.21 µM -0.609472272961483 0.28523101407299 no 2434 0.271105722853982 3552 1245402
SGTC_2037 5169046 200 µM -0.609579453182528 0.285196940051772 no 2435 0.271070212926525 3525 5718022
SGTC_1182 1222-0449 220 µM -0.6100453503241 0.285048847685824 no 2436 0.270915883297679 3502 658318
SGTC_2023 5144124 124 µM -0.61013601204198 0.285020033766608 no 2437 0.270885856466912 3492 2830192
SGTC_924 2046-0044 21.3 µM -0.611311223422933 0.284646656262329 no 2438 0.270496781099596 3552 3623589
SGTC_1713 st033146 12.748 µM -0.614486800821425 0.283638910303354 no 2439 0.269446846287496 3565 674619
SGTC_917 harmaline 728.087 nM -0.615185636114898 0.283417369754365 no 2440 0.269216066316709 3501 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1752 st044819 83.042 µM -0.616198148788783 0.283096536329295 no 2441 0.268881875043488 3458 441209 YML126C ERG13
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.616762522995218 0.282917779574995 no 2442 0.268695687404983 3604 94937 An inhibitor of serotonin biosynthesis.
SGTC_131 0141-0277 33.849 µM -0.618734910905915 0.282293482429324 no 2443 0.26804550376047 3532 1547771
SGTC_1673 st016611 27.3 µM -0.619159404548674 0.282159209095477 no 2444 0.267905676095487 3564 5226799
SGTC_2090 5301565 104.445 µM -0.619487851680372 0.282055337731084 no 2445 0.267797511243319 3563 2056344
SGTC_2403 6032726 181.2 µM -0.623019745754449 0.280939541854309 no 2446 0.266635773082205 3534 2881040
SGTC_1967 st070177 51.4 µM -0.623873170286749 0.280670248377327 no 2447 0.266355440743825 3592 5729214
SGTC_2484 5809818 12.04 µM -0.6249984846578 0.280315352528887 no 2448 0.2659860263251 3540 2870548
SGTC_3276 9139060 49.47 µM -0.625222264149642 0.280244804020793 no 2449 0.26591259569657 3597 4870619
SGTC_3296 9122258 64.045 µM -0.6253292897546 0.280211066271868 no 2450 0.265877480124795 3542 4730474
SGTC_809 3998-0021 90 µM -0.6262070269688 0.279934450883565 no 2451 0.265589579375097 3516 715485
SGTC_2148 5546263 113.568 µM -0.627749353827379 0.279448713704857 no 2452 0.265084074297441 3533 792097
SGTC_700 3453-2283 142 µM -0.629255498591587 0.278974767039691 no 2453 0.264590900181299 3618 565664
SGTC_2911 7942208 15.64 µM -0.630109486750469 0.27870621180613 no 2454 0.264311476624355 3537 1243384
SGTC_1876 myriocin 605 nM -0.63022373389481 0.278670293843047 no 2455 0.26427410653918 3591 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_703 3875-0075 71.8 µM -0.630628891797491 0.278542935119102 no 2456 0.264141601633467 3596 2850814
SGTC_2812 7970281 58.44 µM -0.632303286587267 0.278016901024206 no 2457 0.263594358195673 3598 2233435
SGTC_1603 st002045 67.8 µM -0.632800965798137 0.277860641772185 no 2458 0.263431813001837 3584 5887985
SGTC_710 3448-4187 58 µM -0.633126718813529 0.277758386414005 no 2459 0.26332544770948 3583 3946412
SGTC_3289 9119912 71.43 µM -0.633889173648053 0.277519120228364 no 2460 0.263076575744677 3597 17014829
SGTC_1155 4088-0394 48.2 µM -0.63395232137599 0.277499308338019 no 2461 0.263055969161861 3526 2326248
SGTC_647 0140-0236 81 µM -0.635316317416841 0.277071538704588 no 2462 0.262611066733232 3583 990837
SGTC_2892 9047358 58.44 µM -0.635404666995236 0.277043842083305 no 2463 0.262582262527298 3531 6466771
SGTC_849 0386-0493 241 µM -0.635649200293553 0.276967190649893 no 2464 0.262502546894451 3505 726119
SGTC_1393 3470-5649 58.2 µM -0.635673972009884 0.276959426284293 no 2465 0.262494472231144 3503 4108395
SGTC_2379 9035213 200 µM -0.635888492143532 0.276892192254095 no 2466 0.262424551920426 3593 646551
SGTC_2487 5918373 44.05 µM -0.63685330183625 0.276589904359841 no 2467 0.262110201498602 3628 2876279
SGTC_1214 0358-0031 63.7 µM -0.637382668122087 0.276424115513698 no 2468 0.261937807525208 3616 4301366
SGTC_614 0462-0418 107 µM -0.637962974082135 0.276242429210288 no 2469 0.261748891307002 3462 5188303
SGTC_662 k832-1615 104 µM -0.638508053504037 0.276071825269933 no 2470 0.261571506630799 3557 5878478
SGTC_2818 7996756 12.99 µM -0.638841896067898 0.275967361722765 no 2471 0.261462895041366 3559 2241621
SGTC_3298 9116858 71.43 µM -0.639109901759622 0.275883513413834 no 2472 0.261375719431938 3600 2506942
SGTC_1278 0874-0585 172 µM -0.639893939689199 0.275638291052719 no 2473 0.26112077706768 3559 766306
SGTC_1 0258-0098 57.368 µM -0.642176701599951 0.274924925870182 no 2474 0.260379229321432 3504 6790032 YDR047W HEM12
SGTC_340 k038-0059 454 µM -0.643084188191386 0.274641588417859 no 2475 0.260084736892941 3563 23733424
SGTC_1055 3448-0672 86 µM -0.643158554588919 0.27461837596449 no 2476 0.260060611543994 3561 748378
SGTC_3156 9099931 49.47 µM -0.643300194182433 0.274574167780477 no 2477 0.260014665157321 3581 18111053
SGTC_156 3474-0145 5.642 µM -0.643741379993713 0.274436488507839 no 2478 0.259871575975093 3556 2265471
SGTC_1527 coumarin 137 µM -0.643793111976547 0.274420346925693 no 2479 0.259854800474115 3597 323 A hepatotoxic, DNA x-linker.
SGTC_2685 mycophenolic acid 18.85 µM -0.644628051550353 0.274159891185467 no 2480 0.259584125926329 3544 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1146 3579-1023 7 µM -0.646110213590183 0.273697838220987 no 2481 0.259103990648385 3604 X1146
SGTC_2287 7945887 168.79 µM -0.648329903798849 0.273006587574967 no 2482 0.258385798345292 3594 1245853
SGTC_1171 0368-0077 21.4 µM -0.649002261303704 0.272797374519494 no 2483 0.258168457287875 3574 3239779
SGTC_2340 7987427 183.45 µM -0.649484088927881 0.272647496328563 no 2484 0.258012763756135 3558 2239331
SGTC_2395 5646831 180.19 µM -0.649747441162038 0.272565594773044 no 2485 0.257927687024574 3613 6808628
SGTC_2335 9018011 154.17 µM -0.649863953645376 0.272529363725978 no 2486 0.257890051960739 3611 6458208
SGTC_2978 9011784 42.97 µM -0.65071924118764 0.272263474348736 no 2487 0.257613870093631 3644 2994934
SGTC_179 1273-0063 6.77 µM -0.654265349875757 0.271162447133144 no 2488 0.256470432765253 3565 3108139
SGTC_3330 9141424 71.43 µM -0.654997776807423 0.270935313677032 no 2489 0.256234592721131 3601 27261020
SGTC_402 epigallocatechin gallate 10 µM -0.656350132002975 0.270516183422607 no 2490 0.255799434280194 3580 65064 An antioxidant.
SGTC_3217 9129673 49.47 µM -0.658474216762598 0.269858528634173 no 2491 0.255116729679229 3612 17248312
SGTC_2984 9022109 38.96 µM -0.659784966566623 0.269453096705191 no 2492 0.254695916012466 3658 6459207
SGTC_2703 st077852 53.4 µM -0.661414935917525 0.26894935230496 no 2493 0.254173125022659 3605 6281836
SGTC_2817 7995342 71.43 µM -0.663871247844066 0.268191119678649 no 2494 0.253386359961479 3570 18879975
SGTC_2735 sertaconazole 140 nM -0.66536772170048 0.267729704877022 no 2495 0.252907662524501 3670 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.665694988871227 0.267628850389334 no 2496 0.252803038589966 3461 4000243
SGTC_24 0417-1663 219 µM -0.665788618202131 0.267600000000727 no 2497 0.252773110452482 3602 4329390
SGTC_297 0986-0032 24 µM -0.665961027310279 0.26754687897905 no 2498 0.252718005642126 3587 2847425
SGTC_2300 7976697 71.57 µM -0.666148803214569 0.267489029338481 no 2499 0.252657996546513 3548 2236109
SGTC_2782 7736369 71.43 µM -0.666770775338959 0.267297458418625 no 2500 0.252459281393359 3670 2950836 YOL077C BRX1
SGTC_271 rotenone 740 µM -0.668847194286553 0.266658411414507 no 2501 0.251796478947133 3656 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3195 9113082 49.47 µM -0.668934144782865 0.266631668040733 no 2502 0.251768744005431 3590 17018038
SGTC_1135 dihydrocapsaicin 536.708 nM -0.671210773097301 0.265931928143071 no 2503 0.251043133326801 3596 107982 A Capsaicinoid.
SGTC_1647 st011722 22.4 µM -0.672116258844211 0.265653878715753 no 2504 0.25075484329008 3632 2854783
SGTC_2490 carminic acid 95.39 µM -0.672213646414077 0.265623982491083 no 2505 0.250723847320333 3583 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_848 0368-0089 85.6 µM -0.674196646155613 0.265015608708308 no 2506 0.250093150803538 3617 762535
SGTC_427 1354-0053 47.3 µM -0.675181218308132 0.26471381042883 no 2507 0.249780318883058 3686 6813657
SGTC_2591 skatole 100 µM -0.676493062844585 0.264311965967289 no 2508 0.249363824499577 3651 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2022 5136654 200 µM -0.678021589635829 0.263844139443634 no 2509 0.248879002244153 3633 1713771
SGTC_622 1348-1566 26.3 µM -0.681610359073631 0.262747409177439 no 2510 0.247742681452532 3673 7340407
SGTC_322 k048-0136 19.3 µM -0.681781519850726 0.262695160654198 no 2511 0.247688555698318 3651 6823282
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.682577858188448 0.262452140400957 no 2512 0.247436814635299 3673 6708784 An antioxidant flavonoid
SGTC_2492 derrusnin 100 µM -0.682710651657318 0.262411626737454 no 2513 0.247394848838161 3587 1715307 Part of coumarin class of compounds.
SGTC_3307 9126885 69.2785 µM -0.68356119779888 0.26215221147153 no 2514 0.247126146889565 3641 24824909
SGTC_539 4859-0462 2.54 µM -0.683778357158367 0.262085999266153 no 2515 0.247057567589357 3656 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2698 st077697 67.5 µM -0.685168047507616 0.261662483675423 no 2516 0.246618942133735 3602 3154499
SGTC_1989 st071868 50.2 µM -0.685447239085246 0.261577440929652 no 2517 0.246530871743264 3644 16414057
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.685945138953439 0.261425814081105 no 2518 0.246373852114984 3657 688761
SGTC_2180 6301957 200 µM -0.686142193509394 0.261365816971337 no 2519 0.246311723036362 3620 845462
SGTC_345 1362-0200 395 µM -0.687147364576182 0.261059883084333 no 2520 0.245994934669035 3637 1419823
SGTC_1290 0986-0249 10.2 µM -0.687404993526181 0.260981500780741 no 2521 0.245913775882474 3613 53329
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.689197180352429 0.260436572102753 no 2522 0.245349595488942 3683 23665772 A membrane-active detergent.
SGTC_1553 gossypol 38.6 µM -0.689824230030337 0.260246051130715 no 2523 0.245152364668442 3577 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_202 3594-0513 34.79 µM -0.690963112506464 0.259900200128767 no 2524 0.244794361261003 3635 708429
SGTC_2010 4012422 159 µM -0.691270343970978 0.259806942002184 no 2525 0.244697832431187 3644 952393
SGTC_2764 methyldopa 94.69 µM -0.691380359910124 0.259773551573361 no 2526 0.244663271587633 3682 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_3229 9132204 49.47 µM -0.692032215948269 0.259575755203606 no 2527 0.244458548883574 3659 17682924
SGTC_37 0566-0070 1.56 µM -0.692356378402834 0.259477421712144 no 2528 0.24435677639833 3681 1626686
SGTC_1783 st039459 87.517 µM -0.692981054778902 0.259287982699313 no 2529 0.244160720424308 3715 729761
SGTC_2832 7992762 51.95 µM -0.693551920701875 0.259114924736692 no 2530 0.243981627174398 3594 2985177
SGTC_1636 st007707 68.9 µM -0.695498354315438 0.25852531278338 no 2531 0.243371521082802 3680 403051
SGTC_3074 9116018 49.47 µM -0.697297685167913 0.257980879788169 no 2532 0.242808258216224 3713 17027303
SGTC_39 0986-0283 58.349 µM -0.697509367264163 0.257916869145451 no 2533 0.242742039626842 3700 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_564 3555-0129 330 µM -0.698134417087493 0.257727908152419 no 2534 0.242546568021878 3586 563260
SGTC_258 haloperidol 50.781 µM -0.698843563613364 0.257513610644356 no 2535 0.242324900149345 3680 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_578 3460-0051 92 µM -0.699512955739923 0.257311411497829 no 2536 0.242115759630583 3739 2876744
SGTC_289 k017-0060 526 µM -0.699834752743965 0.257214237640823 no 2537 0.242015254312942 3663 5512909
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.700933607106651 0.256882557666016 no 2538 0.241672225011997 3693 2724 A muscle relaxant with antifungal properties.
SGTC_1261 0712-0010 12.7 µM -0.700971889029007 0.256871006602057 no 2539 0.241660279306122 3686 2840123
SGTC_497 capsazepine 133 µM -0.701239645723545 0.256790222116895 no 2540 0.241576735966991 3672 2733484 A calcium channel blocker.
SGTC_1909 st060837 51.5 µM -0.70220455156395 0.256499211505009 no 2541 0.241275803758895 3671 678937
SGTC_1683 st010134 710 nM -0.703496093848476 0.256109958088527 no 2542 0.240873320100331 3706 3818134
SGTC_3073 9114972 49.47 µM -0.704042970879503 0.255945229622774 no 2543 0.24070300680509 3614 41905075
SGTC_2974 9094440 9.66 µM -0.704234705055645 0.255887489188834 no 2544 0.24064331076859 3751 25236134
SGTC_986 1493-0483 84 µM -0.704539786314128 0.25579562848195 no 2545 0.240548340970019 3625 40079
SGTC_2349 9023730 187.07 µM -0.70677191943178 0.255124051873076 no 2546 0.239854113805412 3672 4126287
SGTC_1825 st052143 62.6 µM -0.709642768042241 0.25426166410799 no 2547 0.238962845578118 3701 674173
SGTC_921 1561-0023 372 µM -0.710435760857537 0.254023722932708 no 2548 0.238716976857685 3684 24050882
SGTC_438 sphingosine 6.67 µM -0.710710504332163 0.253941312135437 no 2549 0.238631824489416 3623 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2732 terfenadine 20 µM -0.711513471981901 0.253700538075678 no 2550 0.238383052754181 3687 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_560 2332-1943 155 µM -0.713972228092659 0.252964013406652 no 2551 0.237622176288795 3685 21177716
SGTC_2353 9059630 146.67 µM -0.716423162229142 0.252230953205911 no 2552 0.236865048548972 3738 4779114
SGTC_2850 9015429 58.44 µM -0.71644564683475 0.252224233379949 no 2553 0.236858108885942 3733 6457570
SGTC_998 3996-0085 177 µM -0.718055959443334 0.251743215458985 no 2554 0.236361391778867 3739 715391
SGTC_107 0358-0022 2.6945 µM -0.718538139177561 0.251599277415681 no 2555 0.236212770239009 3712 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_878 0828-0289 13.7 µM -0.718860770843917 0.251502991199396 no 2556 0.236113354709687 3704 745350 YLR208W SEC13
SGTC_187 1488-2104 32.728 µM -0.721487725096122 0.250719728049332 no 2557 0.235304745109499 3752 2852859
SGTC_2789 5281112 71.43 µM -0.722072216339774 0.25054562966264 no 2558 0.235125039484261 3727 765948
SGTC_1852 st056254 31.4 µM -0.722879139533803 0.250305382294342 no 2559 0.234877070322604 3668 442583
SGTC_3033 9090887 49.47 µM -0.723959321550424 0.249983968140767 no 2560 0.234545354518071 3742 19325384
SGTC_2423 st077119 87.2 µM -0.724835115879814 0.249723531540003 no 2561 0.234276594980906 3664 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_488 nitrendipine 139 µM -0.725064210450285 0.24965542904099 no 2562 0.234206319683523 3740 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1092 toremifene 6.32 µM -0.725741848891657 0.249454046530973 no 2563 0.233998520831672 3707 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3093 9117344 49.47 µM -0.728290773179391 0.248697323735503 no 2564 0.233217804648382 3750 24824913
SGTC_1911 st060208 74.3 µM -0.728789314826987 0.248549460119937 no 2565 0.233065274343656 3757 688783
SGTC_550 4123-0385 25.7 µM -0.728817326470192 0.248541153472154 no 2566 0.233056705741767 3740 5731123
SGTC_1794 st048918 76.9 µM -0.730890913908871 0.247926657238423 no 2567 0.232422893150672 3645 672303
SGTC_1678 st019265 80.2 µM -0.730976737993989 0.247901241228792 no 2568 0.232396680844096 3727 5367020
SGTC_1014 4130-3005 69.3 µM -0.731451208944934 0.247760756140521 no 2569 0.23225179807582 3737 743608
SGTC_1498 4478-3555 97.6 µM -0.732288820725172 0.247512853257296 no 2570 0.231996150633299 3702 3437919
SGTC_2611 pyromycin 23.93 µM -0.732860159890147 0.247343833528314 no 2571 0.231821862165729 3725 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2317 5986382 200 µM -0.734395762191161 0.246889860981278 no 2572 0.231353784427063 3775 877883
SGTC_549 1661-1316 519 µM -0.735408668632179 0.246590658113161 no 2573 0.231045322027114 3751 2857282
SGTC_3047 9092122 49.47 µM -0.735732596751795 0.246495013852841 no 2574 0.230946724022415 3708 17173831
SGTC_2419 paclitaxel 166.5 µM -0.735945330547714 0.246432212070296 no 2575 0.230881984389691 3679 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3222 9128301 49.47 µM -0.737564727064341 0.245954426364447 no 2576 0.230389498273951 3768 4911358
SGTC_1790 st045711 43.5 µM -0.739867314391625 0.245275929244354 no 2577 0.229690254532712 3734 585119
SGTC_2644 guaiazulene 100 µM -0.74418441587225 0.244006537303323 no 2578 0.228382457392983 3772 3515 A coloring agent.
SGTC_1555 citronellol 128 µM -0.744612165877851 0.243880955793969 no 2579 0.22825310557264 3709 8842 A terpine precursor.
SGTC_741 4582-0002 126 µM -0.744764481329131 0.243836246497942 no 2580 0.228207055247448 3707 2912688
SGTC_756 0508-1999 28.3 µM -0.746656209767098 0.243281334506292 no 2581 0.227635554581525 3741 6753853
SGTC_230 MPP+ 141.667 µM -0.746828064181708 0.243230957268107 no 2582 0.227583676454933 3742 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1364 1653-0028 37.6 µM -0.747822415470592 0.242939584825869 no 2583 0.227283639846557 3756 5718652
SGTC_2852 9023854 51.95 µM -0.748386558729311 0.242774359236807 no 2584 0.227113513815216 3832 19798528
SGTC_2836 9010338 19.48 µM -0.748674991517614 0.242689906896997 no 2585 0.227026560236877 3722 2994051
SGTC_412 gemfibrozil 100 µM -0.749512925459379 0.242444652348297 no 2586 0.226774055541633 3722 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1749 st037932 54.2 µM -0.749638330769241 0.242407959072681 no 2587 0.226736279290583 3776 594497
SGTC_3147 9097027 49.47 µM -0.750287996110193 0.242217916817884 no 2588 0.226540635334624 3783 25236841
SGTC_1215 3852-0577 11.2 µM -0.75071011442498 0.242094480669437 no 2589 0.226413567294868 3823 2884876
SGTC_2222 6885208 172.143 µM -0.750869389563177 0.242047914180883 no 2590 0.226365632004879 3716 609514
SGTC_870 0573-2213 57.6 µM -0.751411811847657 0.24188936529148 no 2591 0.226202428130686 3757 3916321
SGTC_1380 2291-0730 164 µM -0.75226544530155 0.241639964185389 no 2592 0.225945721817132 3788 2999191
SGTC_2572 astragaloside iv 100 µM -0.753228304470158 0.241358818863489 no 2593 0.225656366709494 3785 45006101 An anti-inflammatory agent.
SGTC_3100 9120536 49.47 µM -0.753264105355249 0.241348368788268 no 2594 0.225645611995597 3629 16421196
SGTC_1190 1486-1332 13 µM -0.753784891702132 0.241196382009779 no 2595 0.225489198712959 3756 4150046
SGTC_1859 st055998 20 µM -0.756208241284176 0.240489834138217 no 2596 0.224762176202303 3739 676301
SGTC_1058 3448-5425 97.3 µM -0.756720401134947 0.240340654049709 no 2597 0.224608694844465 3674 7279705
SGTC_1659 st012954 42.1 µM -0.756728617556745 0.240338261210715 no 2598 0.224606233075249 3751 24207262
SGTC_1192 1488-0095 21.4 µM -0.756846947161622 0.240303801944536 no 2599 0.224570781361837 3797 915875
SGTC_2695 st077686 51.995 µM -0.7607655199161 0.239164179734071 no 2600 0.223398566223299 3817 2876092
SGTC_27 0485-0001 32.618 µM -0.761286968909289 0.239012751873629 no 2601 0.223242841095555 3701 2054479
SGTC_3091 9116372 49.47 µM -0.763320568791898 0.238422699214154 no 2602 0.222636119081426 3823 17169793
SGTC_638 3970-0837 4.09 µM -0.76399906830012 0.238226008964394 no 2603 0.222433898911485 3763 4118451 YLR208W SEC13
SGTC_2440 5628896 157.78 µM -0.764624836262251 0.23804468389358 no 2604 0.222247487762116 3806 5522048
SGTC_476 mead acid 10 µM -0.76529480448894 0.237850635054848 no 2605 0.222048008559361 3796 5312531 An omega 9 fatty acid.
SGTC_1922 5578187 25 µM -0.767481835921692 0.237217789946775 no 2606 0.22139754436772 3771 1350412
SGTC_1396 3511-0007 98.6 µM -0.768907865122004 0.236805649099956 no 2607 0.22097400399285 3768 X1396
SGTC_1224 0823-0416 294 µM -0.769242694717316 0.236708936136665 no 2608 0.220874624597345 3849 3598164
SGTC_2822 7994718 71.43 µM -0.77021150774726 0.236429224328669 no 2609 0.220587219362666 3748 1018011
SGTC_1768 st044301 37.178 µM -0.770900043897514 0.236230543586328 no 2610 0.220383090560137 3798 3931349
SGTC_3121 9125696 49.47 µM -0.771193181317035 0.236145985150276 no 2611 0.220296217625156 3837 1235365
SGTC_2963 9082507 9 µM -0.771808793263389 0.235968459980504 no 2612 0.220113841462571 3819 16459611
SGTC_2522 biochanin a 4.94 µM -0.773191550987278 0.235569979812662 no 2613 0.219704512840058 3754 5280373 A possible chelator.
SGTC_1429 4049-0205 9.46 µM -0.774517333721821 0.235188267437133 no 2614 0.21931246087478 3809 22774478
SGTC_114 0364-0001 490.298 µM -0.775419826410621 0.234928622016646 no 2615 0.219045811686655 3856 4003655
SGTC_1888 azatryptophan 97.5 µM -0.775982099521152 0.234766937237447 no 2616 0.218879777590926 3828 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_3154 9100113 49.47 µM -0.776185580522675 0.234708440299826 no 2617 0.218819709363218 3821 25237525
SGTC_423 5-fluorouracil 457 µM -0.776299573900406 0.234675672883133 no 2618 0.218786062307538 3768 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1946 st076057 65.1 µM -0.776634289207354 0.23457947352867 no 2619 0.218687282682661 3687 953009
SGTC_3340 9146634 11.102 µM -0.778495933135696 0.23404482317651 no 2620 0.218138351618495 3821 4907387
SGTC_2942 9052777 62.25 µM -0.779356925915196 0.233797780866241 no 2621 0.217884744984488 3886 6469503
SGTC_1855 st056195 39.6 µM -0.780922130899981 0.233349051259724 no 2622 0.217424147438257 3731 4028379
SGTC_3011 9081274 71.4286 µM -0.78278621971213 0.232815258498067 no 2623 0.216876330555852 3803 6625322
SGTC_440 fluspirilene 35.1 µM -0.783149316504889 0.232711362606541 no 2624 0.21676971689574 3927 3396 An atypical antipsychotic.
SGTC_646 4092-0839 27.3 µM -0.783153221364147 0.2327102454169 no 2625 0.216768570503014 3838 877796
SGTC_151 3013-0144 2.285 µM -0.784170720764008 0.232419237992624 no 2626 0.216469971443573 3788 906558 YHR107C CDC12
SGTC_1766 st045414 44.774 µM -0.784281964468762 0.232387434287986 no 2627 0.216437339903051 3842 253960
SGTC_2750 bromebric acid 70.15 µM -0.784339090566983 0.232371103324324 no 2628 0.216420583992933 3886 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1377 2944-0135 198 µM -0.784917893089581 0.232205673751669 no 2629 0.216250855191183 3861 1894137
SGTC_82 0054-0107 293.755 µM -0.785074782906459 0.232160843817572 no 2630 0.216204861897484 3796 3104697
SGTC_1788 fluconazole 20 µM -0.785879328396362 0.231931027474177 no 2631 0.215969093050493 3859 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2630 antimycin a 100 µM -0.788105720998771 0.231295725021517 no 2632 0.2153174345459 3811 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_3 0833-0587 95.581 µM -0.78828278690499 0.231245240863128 no 2633 0.215265656906197 3755 5382644
SGTC_2216 7189485 200 µM -0.790947895869726 0.230486121140527 no 2634 0.21448719863773 3808 731273
SGTC_2731 amoxapine 43.43 µM -0.791606397688105 0.230298770760169 no 2635 0.21429510768325 3868 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1276 0871-0068 94.2 µM -0.791776711264963 0.2302503287023 no 2636 0.214245441960339 3814 3414906
SGTC_284 0988-0104 32.6 µM -0.792449298593049 0.2300590813095 no 2637 0.214049371926204 3820 4666532
SGTC_1847 st056231 15 µM -0.792886774084499 0.2299347347093 no 2638 0.213921896853077 3824 5393180
SGTC_2998 9066762 71.4286 µM -0.793227589377516 0.229837888562578 no 2639 0.213822618030017 3829 4945196
SGTC_2552 juarezic acid 87.02 µM -0.793502240575563 0.229759860239746 no 2640 0.213742632204068 3857 1549512
SGTC_2854 9024559 71.43 µM -0.794118418330707 0.229584858308073 no 2641 0.213563248066417 3856 3163529
SGTC_2646 retinol 96.75 µM -0.794306382204249 0.229531489163745 no 2642 0.213508544736683 3799 445354 A vitamin A analog and teratogen.
SGTC_534 k292-0788 63.4 µM -0.795015996191882 0.229330069014937 no 2643 0.213302098628906 3821 4146317
SGTC_1751 st044839 27.194 µM -0.796535225343382 0.228899177248044 no 2644 0.212860504867235 3783 5291326
SGTC_2273 7815444 169.05 µM -0.796710419245954 0.228849517067057 no 2645 0.212809615659054 3749 2824616
SGTC_269 exalamide 29 µM -0.799375384149735 0.228094856454637 no 2646 0.21203638972338 3781 3316 A derivative of salicylamide.
SGTC_2281 7943571 200 µM -0.800195536382469 0.22786288894971 no 2647 0.21179875777575 3946 1244024
SGTC_2348 9022543 33.42 µM -0.800367082099023 0.227814386660805 no 2648 0.211749073615289 3869 3162678 YDL140C RPO21
SGTC_1031 k035-0009 16 µM -0.800721405587686 0.227714224762758 no 2649 0.211646473790258 3917 5180959
SGTC_449 xestospongin c 11.1929 µM -0.802002212651672 0.22735236678186 no 2650 0.211275839163153 3849 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_783 0848-0141 92.7 µM -0.803989605191946 0.226791523747175 no 2651 0.210701489160766 3813 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3221 9128209 49.47 µM -0.804785323652563 0.226567190670851 no 2652 0.21047178613286 3878 16460723
SGTC_422 cantharidin 155 µM -0.807425441786643 0.225823772864632 no 2653 0.209710706980102 3790 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1111 tnp00062 510.699 nM -0.80834491780327 0.22556518642649 no 2654 0.20944602575352 3918 676306
SGTC_2734 clemastine 41.6 µM -0.810132161388273 0.225063035377876 no 2655 0.20893211083211 3847 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_920 mycophenolic acid 780.421 nM -0.8117924477303 0.224597122814288 no 2656 0.208455368166872 3886 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1068 loratadine 26.9 µM -0.811876181148677 0.224573639892878 no 2657 0.208431341552425 3898 3957 A H1 histamine antagonist.
SGTC_1049 3226-0134 66 µM -0.81214918905401 0.224497084878704 no 2658 0.208353015527885 3885 5702385
SGTC_2261 9010538 184.68 µM -0.812443196130705 0.224414657983298 no 2659 0.208268684256417 3840 6457250
SGTC_2549 cedrol 20.94 µM -0.812923080908398 0.224280155907909 no 2660 0.208131080179979 3774 6708665 A sedative which affects the nervous system.
SGTC_2221 6807166 181.081 µM -0.813310002097859 0.224171742996386 no 2661 0.208020171935059 3774 674925
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.815154597321123 0.223655308206447 no 2662 0.207491911483638 3837 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2077 5212015 200 µM -0.815242358869757 0.223630754311446 no 2663 0.207466797855578 3739 780900
SGTC_1827 berberine 7.24 µM -0.815526686783362 0.223551215677142 no 2664 0.207385447622149 3789 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1067 clotrimazole 1.36 µM -0.817508162767582 0.222997359389401 no 2665 0.206819043198567 3864 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2916 7875993 68.79 µM -0.81832462975908 0.222769370516573 no 2666 0.206585922969111 3786 1299250
SGTC_414 piperonyl butoxide 100 µM -0.819877994551067 0.222335978507455 no 2667 0.206142831314237 3850 5794 A potent inhibitor of cytochrome P450.
SGTC_2945 9067681 61.76 µM -0.823556117069469 0.221311694825209 no 2668 0.205095909492168 3957 16456930
SGTC_1013 4112-3890 241 µM -0.824101780482429 0.22115996867491 no 2669 0.204940864287059 3829 705171
SGTC_3328 9140624 29.0385 µM -0.824357030477971 0.221089014772935 no 2670 0.204868361293674 3900 4904392
SGTC_313 3474-0040 5.03 µM -0.82483561735239 0.220956013230085 no 2671 0.204732461246921 3852 1043375 YIL048W NEO1
SGTC_742 0kpi-0133 140 µM -0.824971245618828 0.220918329827341 no 2672 0.20469395785115 3932 2728852
SGTC_636 0kpi-0074 126 µM -0.826278094430489 0.220555419228454 no 2673 0.204323178395254 3895 616434
SGTC_2277 7947813 106.88 µM -0.827071606010733 0.220335228637707 no 2674 0.20409823834166 3970 1246798
SGTC_350 k064-0020 19.8 µM -0.827313399018517 0.220268158840803 no 2675 0.204029725597895 3839 2790705
SGTC_3234 9132280 49.47 µM -0.828186869595728 0.220025968595168 no 2676 0.203782339377784 3915 17612295
SGTC_428 3448-4153 16.5 µM -0.828463272641094 0.219949361188165 no 2677 0.203704093170121 3842 3834874
SGTC_909 3448-9333 149 µM -0.82867920088659 0.219889525525885 no 2678 0.203642979078315 3800 3344074
SGTC_1354 1498-1681 81 µM -0.829009921133965 0.219797898079563 no 2679 0.203549396647946 3916 5754243
SGTC_514 4466-0038 2.65 nM -0.829907878403649 0.219549225782393 no 2680 0.203295435090631 3776 5722064
SGTC_304 1310-0298 97 µM -0.830102982937157 0.219495216646274 no 2681 0.203240280364221 3780 1550234
SGTC_2141 5621638 7.665 µM -0.831756611708243 0.219037763179413 no 2682 0.202773169477275 3919 2856238
SGTC_1114 scopoletin 1.73284 µM -0.832776740708559 0.218755832301872 no 2683 0.202485327421433 3868 5280460 A coumarin with genotoxic properties.
SGTC_2051 5263410 176 µM -0.835125519993088 0.218107499723703 no 2684 0.201823519627908 3915 227584
SGTC_183 3914-0051 30.55 µM -0.835830251120351 0.217913189298946 no 2685 0.201625202746567 3914 1596232
SGTC_2873 9040596 71.43 µM -0.836890054446087 0.217621165401836 no 2686 0.201327185628425 3849 6463863
SGTC_2654 protoveratrine a 100 µM -0.838078631662226 0.217293927267951 no 2687 0.200993271556269 3874 5702278 A heart drug and vasodilator.
SGTC_1124 fisetin 1.16336 µM -0.83863288189916 0.217141428741512 no 2688 0.200837676389167 3906 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1514 1189-1591 158 µM -0.839791403612182 0.216822868428918 no 2689 0.200512677089961 3934 767698 YMR146C TIF34
SGTC_1833 st055984 71 µM -0.839988157423524 0.21676879361663 no 2690 0.200457513269982 3915 676288
SGTC_2561 acetosyringone 100 µM -0.840188413762137 0.216713764196265 no 2691 0.200401376808346 3899 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_227 fluconazole 33.516 µM -0.841696612117084 0.216299578614041 no 2692 0.199978897547416 3891 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.841907921962514 0.216241584745434 no 2693 0.199919747851119 3923 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3327 9140648 26.9345 µM -0.845859030331534 0.215158864338216 no 2694 0.198815695067238 3921 8029710
SGTC_2894 9048625 32.47 µM -0.848143012024089 0.214534423880832 no 2695 0.198179165037948 3900 4092861
SGTC_2449 5812982 45.77 µM -0.848857546937295 0.21433928665054 no 2696 0.197980281988907 3876 776185
SGTC_1030 k029-0042 36.7 µM -0.848899271696413 0.214327894941517 no 2697 0.197968672080735 3895 6080581
SGTC_3070 9117005 49.47 µM -0.851250505246071 0.213686529538414 no 2698 0.197315106337941 3937 8779016
SGTC_862 0452-0056 10.2 µM -0.85221126824406 0.213424776372779 no 2699 0.197048421797643 3875 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2800 7887935 81.82 µM -0.8545416728697 0.212790650906875 no 2700 0.19640246482509 3942 2961002
SGTC_736 0958-0254 92.6 µM -0.854820587302023 0.212714829378795 no 2701 0.196325239566335 4006 6812352
SGTC_3079 9117512 49.47 µM -0.857143968886478 0.212083842682147 no 2702 0.195682661984512 3930 7185044
SGTC_1217 1183-1422 255 µM -0.858066000799865 0.21183373983996 no 2703 0.195428009925593 3938 2849664
SGTC_291 SEC14.278 35.5 µM -0.859365229467023 0.211481614740423 no 2704 0.195069523344409 3919 1068044
SGTC_726 3448-4391 34.2 µM -0.860821327122273 0.211087381635187 no 2705 0.194668228464856 4022 1356692
SGTC_707 0865-0008 204 µM -0.861057387554306 0.211023509738206 no 2706 0.19460321847047 3917 723043
SGTC_2187 6125751 200 µM -0.863366600425518 0.210399293700945 no 2707 0.193967968455637 3917 874498
SGTC_1606 st000094 49.2 µM -0.864484423655161 0.210097518527064 no 2708 0.193660916694445 3904 1242210
SGTC_1294 1000-1494 117 µM -0.865659254544765 0.20978062740198 no 2709 0.193338525305387 3912 712797 YDL207W GLE1
SGTC_2 0422-0095 29 µM -0.867508232284901 0.209282465894861 no 2710 0.192831801581587 3791 6790840
SGTC_2733 amorolfine 100 µM -0.870108712675006 0.208583010079363 no 2711 0.192120498375456 3993 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_656 4090-1979 187 µM -0.871011747343155 0.208340442005228 no 2712 0.191873869458512 3967 22330961
SGTC_1662 st014054 52 µM -0.872240301654405 0.208010702006789 no 2713 0.191538648836316 3950 2838777
SGTC_896 0964-0007 44.5 µM -0.873087140848355 0.207783592587428 no 2714 0.19130779118386 3869 6756758
SGTC_1255 0566-0045 221 µM -0.875201104034027 0.207217299260782 no 2715 0.190732246308616 3997 2788469
SGTC_224 benfluorex 43.875 µM -0.876114183785151 0.206972983899523 no 2716 0.190483981356439 3933 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.877351477230326 0.206642189887022 no 2717 0.190147879992951 3905 688803
SGTC_1046 2001-0062 216 µM -0.877867510532071 0.206504319451182 no 2718 0.190007811217664 3846 739778
SGTC_3279 9140807 49.47 µM -0.878026729505371 0.206461791359915 no 2719 0.189964606644967 3976 45595718
SGTC_988 1497-1057 103 µM -0.878950467130756 0.20621515935759 no 2720 0.189714066685634 3861 3533044
SGTC_2333 9017922 200 µM -0.881545191005376 0.205523319708059 no 2721 0.189011402797594 4011 3163164
SGTC_1971 st069429 63.5 µM -0.882671156100117 0.205223529252559 no 2722 0.188706985378402 3939 1246522 YGL099W LSG1
SGTC_2722 naftopidil 47.16 µM -0.882977575071752 0.205141989585468 no 2723 0.188624193879197 3855 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.883109753280738 0.20510682222746 no 2724 0.18858848749541 4037 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1412 3909-8563 178 µM -0.884587345531591 0.204713937719354 no 2725 0.188189617115312 4020 23767530
SGTC_2702 st077768 96.8 µM -0.885600293263565 0.204444858725554 no 2726 0.18791647674811 3935 6484119
SGTC_842 0271-0008 11.1 µM -0.886946156834663 0.204087669963536 no 2727 0.187553944843845 4013 1221709
SGTC_2697 mebhydrolin 72.4 µM -0.887594085579825 0.203915843969583 no 2728 0.187379568116541 4028 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2394 5221648 200 µM -0.887923684851417 0.203828469729779 no 2729 0.187290901705709 4023 788586
SGTC_3135 9127742 49.47 µM -0.888134045007924 0.203772716532878 no 2730 0.187234325702335 4032 3643468
SGTC_1815 st051655 58.2 µM -0.888993266018556 0.203545085705203 no 2731 0.187003349438209 3901 5984156
SGTC_3258 9138477 49.47 µM -0.889755420386112 0.203343297435494 no 2732 0.18679861428305 3990 4970355
SGTC_2624 nerol 100 µM -0.891600349005732 0.202855327925712 no 2733 0.18630359151503 3865 637566 A natural product oil.
SGTC_812 4251-0442 148 µM -0.893816088052796 0.202270207365444 no 2734 0.185710149964852 3958 5723007
SGTC_1605 st000082 49.1 µM -0.895478354909499 0.201831908293886 no 2735 0.185265715706192 3961 1114022
SGTC_1245 0418-0076 17.2 µM -0.896699097003663 0.201510390947799 no 2736 0.184939751304259 4020 6790114
SGTC_1033 k072-0102 21.3 µM -0.897051479305563 0.201417638100921 no 2737 0.184845723973224 3948 5965931
SGTC_1184 1269-1718 139 µM -0.898079936904322 0.201147077412603 no 2738 0.184571467187964 4035 5403821
SGTC_1204 4049-0315 18.3 µM -0.899108242043088 0.200876774851008 no 2739 0.184297504199392 4073 588402
SGTC_827 3253-0474 693 µM -0.899354029514422 0.200812198902347 no 2740 0.184232058526735 3990 5402065
SGTC_154 3389-1638 511.116 µM -0.900040238108976 0.200631976699498 no 2741 0.184049418773347 3980 5238686
SGTC_63 0099-0242 26.702 µM -0.903318481454116 0.199772337135559 no 2742 0.183178445282093 4024 3898502 YLR359W ADE13
SGTC_782 0083-0095 30.5 µM -0.906064970406239 0.199053845758838 no 2743 0.182450732470714 3947 3591729 An indicator and reagent.
SGTC_1988 st071872 53.4 µM -0.907054720386158 0.198795305723338 no 2744 0.182188930482308 4000 16414116
SGTC_353 1988-1175 58.3 µM -0.908754586951415 0.198351743496875 no 2745 0.181739841497964 3821 2788357
SGTC_1490 4089-0339 670 nM -0.909187004982782 0.19823900394028 no 2746 0.181625711252872 3915 742542
SGTC_2177 5811945 192 µM -0.909731015898325 0.198097224962098 no 2747 0.181482191463487 4021 5343475
SGTC_1209 2323-2347 50.3 µM -0.912156026967298 0.197465968804877 no 2748 0.180843294149574 3981 5412760
SGTC_3108 9121785 49.47 µM -0.912572901980165 0.19735757445577 no 2749 0.180733605767525 3845 17140271
SGTC_1973 st070275 50.2 µM -0.913070841829616 0.197228149092141 no 2750 0.180602642240386 3905 17118334
SGTC_2251 lansoprazole 556 µM -0.913766138903851 0.197047512239939 no 2751 0.180419871242166 3907 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_3237 9133362 49.47 µM -0.915135523347114 0.196692041700541 no 2752 0.18006024405664 3932 43845137
SGTC_2184 6075246 200 µM -0.91631279856843 0.196386750393832 no 2753 0.179751428559846 4018 2267320
SGTC_85 0868-0259 160.055 µM -0.916398130652289 0.196364633225279 no 2754 0.179729057720152 3931 83173
SGTC_317 4495-0002 170 µM -0.917202555425074 0.196156209092179 no 2755 0.179518253996262 4023 15991618
SGTC_1702 st027038 51 µM -0.919282942361823 0.195617809303802 no 2756 0.178973798749127 4016 5521182
SGTC_300 r073-0011 5.04 µM -0.919285943065738 0.195617033376479 no 2757 0.178973014190185 3985 2735780
SGTC_2031 5180455 200 µM -0.922446637302834 0.194800773391018 no 2758 0.178147826371811 3937 29949
SGTC_2930 9013230 14.89 µM -0.922456015087448 0.194798354633043 no 2759 0.17814538161221 4028 2995857
SGTC_2493 resveratrol 26.09 µM -0.924869123040432 0.194176562869792 no 2760 0.177516994772815 3872 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_279 1273-0055 2.93 µM -0.925677055307384 0.193968651300052 no 2761 0.177306917685653 4009 2847562
SGTC_2528 xanthyletin 44.79 µM -0.92591366979845 0.193907787121849 no 2762 0.177245423345744 4040 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_142 0335-0849 62.6745 µM -0.925967672199037 0.193893897754062 no 2763 0.177231390413021 4011 3889043 YPR107C YTH1
SGTC_930 2810-3379 265 µM -0.926482168649008 0.193761600149231 no 2764 0.177097729803954 4049 1015764
SGTC_2013 4024628 200 µM -0.929023344486035 0.193108969781671 no 2765 0.176438494177895 4066 5230760
SGTC_852 0418-0143 439 µM -0.930868818115746 0.192635853449344 no 2766 0.175960713008074 4030 5369229
SGTC_1254 0550-0035 264 µM -0.931457564501874 0.192485068180783 no 2767 0.175808462913532 4089 15121435
SGTC_2761 levamisole 97.89 µM -0.931508932148522 0.192471915711182 no 2768 0.175795183174702 3942 26879 An alkaline phosphatase inhibitor.
SGTC_2076 5212012 200 µM -0.933354024032099 0.191999852083124 no 2769 0.175318605093235 3948 604802
SGTC_303 1348-1668 34.2 µM -0.934817133052133 0.191626022304257 no 2770 0.174941274224752 4021 5380509
SGTC_2904 7225135 42.03 µM -0.93850826310187 0.190684907805571 no 2771 0.173991636253693 4125 4446116
SGTC_2011 4012611 177 µM -0.938991760351923 0.19056184267967 no 2772 0.173867487397268 4017 2049887
SGTC_1307 1187-1599 12.2 µM -0.941242566961545 0.189989584319182 no 2773 0.173290283703874 4007 1538471
SGTC_3203 9113543 49.47 µM -0.941296356213587 0.189975921558482 no 2774 0.173276504768027 4114 17018012
SGTC_1742 st038235 28.8875 µM -0.942246833660249 0.189734594788781 no 2775 0.173033140582371 4075 564103 YBR002C RER2
SGTC_1684 st024538 14.6195 µM -0.943103706234933 0.189517196030853 no 2776 0.172813930105255 4012 6732859
SGTC_3058 9093861 49.47 µM -0.947394336195894 0.188430919112504 no 2777 0.171718938063704 4037 17217477
SGTC_2520 obtusaquinone 4.71 µM -0.947748824671078 0.188341343835069 no 2778 0.171628669311921 4074 5967872
SGTC_1803 st050068 52.4 µM -0.94778850238637 0.18833131935456 no 2779 0.171618567463193 4085 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2258 7960471 200 µM -0.948025299181244 0.188271500050902 no 2780 0.171558287480417 4054 2974708
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.948427124378983 0.188170018310786 no 2781 0.171456028138491 3986 6708514
SGTC_326 k292-0812 17.5 µM -0.94939538000603 0.187925622162395 no 2782 0.17120977960847 4003 3579357
SGTC_349 k015-0014 24 µM -0.949786324465373 0.187826999944457 no 2783 0.171110418022985 4012 2196908
SGTC_3182 9108849 49.47 µM -0.951755640226689 0.187330693594451 no 2784 0.170610461993783 4072 17133045
SGTC_1634 st006576 41 µM -0.955510900023243 0.18638654378272 no 2785 0.169659697914542 4051 3915356
SGTC_3165 9101544 49.47 µM -0.955660292093735 0.186349044602005 no 2786 0.169621944959699 4053 5002184
SGTC_1717 st033143 58.0435 µM -0.959359864386884 0.185421899666449 no 2787 0.168688743466808 4104 674616
SGTC_2017 5132927 60.65 µM -0.959374372720092 0.185418269398113 no 2788 0.168685090308727 4050 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2200 6600604 21.907 µM -0.960452951293837 0.185148511544334 no 2789 0.168413649618974 4013 2904777
SGTC_1404 3909-7820 48.3 µM -0.964334385515166 0.184179764110755 no 2790 0.167439153396111 4013 23741373
SGTC_81 0411-0046 9.971 µM -0.964999538741468 0.184014069097669 no 2791 0.16727252140726 3994 12925265
SGTC_1102 cgs 12066b 26.1 µM -0.965575050223392 0.183870779480446 no 2792 0.167128432450433 4051 6438352 A 5-HT1B full agonist.
SGTC_360 0957-0399 1.01 µM -0.96880689764009 0.18306741246471 no 2793 0.166320772224982 4068 6752301 YPR165W RHO1
SGTC_1802 st050112 57.9 µM -0.970051504284379 0.182758615240455 no 2794 0.166010410092286 4049 4662563
SGTC_824 1304-0008 100 µM -0.970762255754498 0.18258241786724 no 2795 0.165833341085028 4077 768245
SGTC_1394 3474-0001 65.7 µM -0.971426689769485 0.182417798703785 no 2796 0.165667921563597 4038 5017666 YIL048W NEO1
SGTC_2283 7944793 200 µM -0.971883571473483 0.182304656204818 no 2797 0.165554236829854 4098 2970533
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.973570867985863 0.181887193065346 no 2798 0.165134828420731 4088 4174840
SGTC_276 colchicine 750 µM -0.975899915297568 0.181311934009809 no 2799 0.164557032055384 4131 2833 A microtubule depolymerizer.
SGTC_2264 7948757 110.76 µM -0.979011502983333 0.180545172690701 no 2800 0.163787147941598 4022 2971411
SGTC_112 phenothiazine 287.218 µM -0.979405827697162 0.180448148108008 no 2801 0.163689749386283 3985 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2788 5282734 71.43 µM -0.980457081633573 0.180189644323335 no 2802 0.16343027250924 4162 743706
SGTC_290 2043-6722 48.1 µM -0.981077845501979 0.18003710743542 no 2803 0.163277177328716 4081 773758 YLR208W SEC13
SGTC_760 0568-0725 82.9 µM -0.98183332662572 0.179851576630202 no 2804 0.163090983405506 4096 3916171
SGTC_2969 9091408 28.7 µM -0.982668160141386 0.179646698218339 no 2805 0.162885393069858 4014 4286311
SGTC_1813 st051246 8.6015 µM -0.984333171116656 0.179238522181409 no 2806 0.162475862448669 3990 5291959
SGTC_2835 9006588 71.43 µM -0.984855264010485 0.179110651765138 no 2807 0.16234758517657 4147 2345538
SGTC_2799 7812892 81.82 µM -0.987009815601686 0.178583568651209 no 2808 0.16181891334803 4119 20205235
SGTC_2634 4'-methoxyflavone 100 µM -0.98741721027947 0.178484014751463 no 2809 0.16171907537059 4086 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.987706460423947 0.178413352727292 no 2810 0.161648214800625 4117 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3282 9108498 15.4605 µM -0.988230408359934 0.178285400366026 no 2811 0.161519909450172 4071 16459645
SGTC_1655 st012546 55.1 µM -0.988738905015037 0.178161276642172 no 2812 0.1613954513461 4067 720985 YLR208W SEC13
SGTC_2877 9040724 71.43 µM -0.990327059301673 0.177773959991572 no 2813 0.161007142313594 4073 6463895
SGTC_598 3937-0236 20.2 µM -0.99062957271302 0.177700243751938 no 2814 0.160933245963938 4153 1379313
SGTC_163 TUB2.036 7.546 µM -0.991188484095519 0.177564099389414 no 2815 0.160796776341006 4066 15992207 YJR013W GPI14
SGTC_83 0170-0301 39.027 µM -0.992132044257527 0.177334408445081 no 2816 0.160566558371443 4039 3089716
SGTC_712 r015-0009 80.6 µM -0.992992127736166 0.177125201761213 no 2817 0.160356895436024 4107 6813872 YLR060W FRS1
SGTC_2081 5214970 32.255 µM -0.99507995377187 0.176618007907474 no 2818 0.159848689745226 4035 2063512
SGTC_2647 atorvastatin 60.16 µM -1.0001242211574 0.175396402616322 no 2819 0.158625197914914 4064 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1741 st038134 10.228 µM -1.00133295036457 0.175104473725635 no 2820 0.158332933927481 4165 1272587
SGTC_3022 9087993 49.47 µM -1.00645273969395 0.173871376813168 no 2821 0.157098917367978 4152 17173644
SGTC_2059 5238311 157 µM -1.00768506283878 0.173575399404457 no 2822 0.15680283905674 4093 703021
SGTC_943 3253-1379 105 µM -1.00871468878569 0.173328351481789 no 2823 0.156555742586128 4125 668464
SGTC_1200 1643-0193 18.4 µM -1.00899884847289 0.173260209788124 no 2824 0.156487593221424 4114 5403974
SGTC_2879 9041815 71.43 µM -1.01093542860388 0.172796270859499 no 2825 0.156023667926545 4110 4942971
SGTC_3032 9089427 49.47 µM -1.01166418302248 0.172621891243911 no 2826 0.155849323183735 4118 17173707
SGTC_135 0933-0004 26.348 µM -1.01305829547928 0.17228861452955 no 2827 0.155516158441348 4087 21230617 YGL099W LSG1
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.01375553109655 0.172122087394788 no 2828 0.155349709587208 4104 616764
SGTC_533 1222-0222 6.71 µM -1.01477885413474 0.171877863930482 no 2829 0.155105627890821 4156 3982874
SGTC_735 3076-0345 636 µM -1.01506123677584 0.171810510239557 no 2830 0.155038318945018 4167 2888990
SGTC_1960 st011366 51.8 µM -1.01524154572119 0.171767511907357 no 2831 0.154995350455896 4118 3972846
SGTC_2417 cerulenin 830 nM -1.01584523450587 0.171623600082075 no 2832 0.15485154576199 4137 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1835 st008666 49.2 µM -1.02040403833076 0.170539326892034 no 2833 0.153768439717214 4051 690455
SGTC_1239 0337-0584 35.4 µM -1.0230059315081 0.169922458887216 no 2834 0.153152520665562 4180 914301 YML130C ERO1
SGTC_341 1486-1430 230 µM -1.02468822561193 0.169524375813522 no 2835 0.152755160244184 4080 2054753 YPL210C SRP72
SGTC_1871 st057448 67.3 µM -1.02489893601654 0.169474557383896 no 2836 0.152705438356811 4177 691747
SGTC_639 0833-0042 114 µM -1.0300653183524 0.168256005200404 no 2837 0.151489672187722 4121 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_76 0433-0009 400.328 µM -1.03102673564741 0.168029867132963 no 2838 0.151264141224885 4205 2841569
SGTC_3274 9138298 49.47 µM -1.03131121093903 0.167962992298821 no 2839 0.151197451349863 4078 17015756
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.03151949106063 0.167914040392229 no 2840 0.151148636402425 4074 279621
SGTC_1227 3909-8010 46.6 µM -1.03280187721552 0.167612844594396 no 2841 0.150848312538939 4101 15982272
SGTC_2389 9091542 195.52 µM -1.03350087605086 0.16744881640567 no 2842 0.150684780380172 4112 3626624 YOL127W RPL25
SGTC_117 lucigenin 22.078 µM -1.03493613203403 0.167112341258269 no 2843 0.150349369592162 4140 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_420 mitomycin C 81.9 mM -1.0373229568023 0.166553750460698 no 2844 0.149792685187647 4115 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_182 3448-4371 550.524 µM -1.03760985786934 0.166486687973475 no 2845 0.149725863303355 4006 3491403
SGTC_2404 5161160 200 µM -1.03866508954669 0.166240179902788 no 2846 0.149480261292336 4090 2831543
SGTC_410 α-linolenic acid 100 µM -1.03981916716781 0.16597085090509 no 2847 0.149211961206318 4200 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1616 st002734 56.1 µM -1.03997107062039 0.165935421957759 no 2848 0.149176670640307 4080 4026101
SGTC_1009 4106-0057 9.87 µM -1.04106541692141 0.165680328388886 no 2849 0.148922594282858 4139 2928005
SGTC_734 2023-0417 80 µM -1.04254018536838 0.165336959252457 no 2850 0.148580652257005 4125 3935732
SGTC_1685 st024049 53.0905 µM -1.04400499554471 0.164996364833557 no 2851 0.148241539195587 4161 1941139
SGTC_1570 verbenone 133 µM -1.04781908707656 0.164111653839378 no 2852 0.147360983386408 4166 29025 A natural terpanoid with antifungal properties.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.04925026026528 0.163780476436492 no 2853 0.14703147599268 4095 16623 A steroid.
SGTC_1288 0973-0013 65.5 µM -1.04943918077012 0.163736792145643 no 2854 0.1469880166603 4177 4315430
SGTC_86 0417-1630 471.922 µM -1.04986358008159 0.16363868542036 no 2855 0.146890419124835 4142 3634867
SGTC_2648 atorvastatin 78.68 µM -1.05144873480379 0.163272588979486 no 2856 0.146526271410052 4143 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1337 1486-1011 40.3 µM -1.05237908594758 0.163057969484178 no 2857 0.146312830052711 4114 X1337
SGTC_2465 5809242 33.21 µM -1.0524094036149 0.16305097869272 no 2858 0.146305878081366 4192 2731748
SGTC_1515 3460-0031 42.1 µM -1.05305867360638 0.162901313701835 no 2859 0.146157050921402 4089 2876596
SGTC_2970 9090938 41.86 µM -1.0545569703792 0.162556278255477 no 2860 0.145813996097295 4218 17217104
SGTC_1508 1080-0625 72.9 µM -1.054782063575 0.162504483756497 no 2861 0.145762504836909 4019 767111
SGTC_510 ag-490 170 µM -1.0574218094896 0.161897873251838 no 2862 0.145159561154223 4262 5328779
SGTC_2164 5685496 200 µM -1.05861240087139 0.161624760118758 no 2863 0.144888168468036 4082 759046
SGTC_2246 7293507 91.5585 µM -1.06136899194816 0.160993571217306 no 2864 0.144261121500677 4204 887656
SGTC_1008 4106-0037 6 µM -1.06246533831127 0.160742983689777 no 2865 0.144012242737578 4108 2905394
SGTC_400 oxethazaine 37.5 µM -1.06728350551404 0.159644735266253 no 2866 0.142921917062042 4157 4621 A local anesthetic.
SGTC_1366 1683-0113 21.9 µM -1.06867807371163 0.159327777203873 no 2867 0.142607377423385 4173 708623
SGTC_1643 st009866 20.2 µM -1.06969984534979 0.159095810242572 no 2868 0.142377217990049 4108 3156273 YOR207C RET1
SGTC_1375 2910-0797 186 µM -1.06977909044129 0.159077828933044 no 2869 0.142359378122975 4166 742508
SGTC_1333 1482-0047 286 µM -1.0707884567964 0.158848912574302 no 2870 0.142132279170447 4182 3811116
SGTC_1317 1273-0028 910 nM -1.0720077414582 0.158572676467904 no 2871 0.141858277512978 4155 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2160 5660466 132.927 µM -1.07526556562563 0.15783614351754 no 2872 0.14112792411733 4077 2859134
SGTC_989 1501-0895 10.3 µM -1.07630778871469 0.157600991526337 no 2873 0.14089481322271 4140 2830112
SGTC_2961 9083290 32.55 µM -1.08259711798905 0.156186847279571 no 2874 0.139493643546297 4114 17741490
SGTC_2694 st077685 81.9 µM -1.08362500812641 0.155956525345663 no 2875 0.139265548991502 4118 2838096
SGTC_765 1319-0117 244 µM -1.0857165322191 0.155488563841397 no 2876 0.138802212075741 4144 3487746 YGL099W LSG1
SGTC_1481 3346-2004 36 µM -1.08829381994442 0.154913192088241 no 2877 0.138232708964306 4258 2770522
SGTC_2838 9002687 71.43 µM -1.0936566846465 0.153720461642004 no 2878 0.137052789145687 4183 6457060
SGTC_1669 st015249 58.4 µM -1.09367068179343 0.153717356575712 no 2879 0.137049718570632 4265 722793
SGTC_3078 9116413 49.47 µM -1.09777574854211 0.152808498115042 no 2880 0.136151211830607 4118 17177322
SGTC_2858 9025781 8.96 µM -1.09803733135268 0.152750704919269 no 2881 0.136094094191171 4088 4894980 YPL153C RAD53
SGTC_966 1300-0360 30.2 µM -1.10013434863876 0.152287921228474 no 2882 0.135636794965602 4169 70588
SGTC_2855 9016525 58.44 µM -1.10071742455796 0.152159409718624 no 2883 0.135509830112197 4155 43811474
SGTC_2618 avocadyne 43.43 µM -1.10163692440389 0.151956895826281 no 2884 0.135309774424562 4109 3015189
SGTC_152 4469-0003 551.229 µM -1.10325730223359 0.151600454048856 no 2885 0.134957721576534 4148 697280
SGTC_675 1309-0189 238 µM -1.10381464910606 0.151477980521855 no 2886 0.134836774454488 4219 4246530
SGTC_3228 9131799 49.47 µM -1.1039008139918 0.151459052194292 no 2887 0.134818082872567 4191 17015818
SGTC_1472 k841-0093 193 µM -1.10528252279711 0.151155739223214 no 2888 0.134518594263336 4308 X1472
SGTC_786 4544-0069 423 µM -1.10752452376316 0.150664435186082 no 2889 0.13403360770776 4201 748821 YLR208W SEC13
SGTC_1350 1495-0454 146 µM -1.10938280415428 0.15025802516454 no 2890 0.133632538678496 4243 1069057
SGTC_1300 1094-0077 113 µM -1.11055858512747 0.150001257000172 no 2891 0.133379198827345 4185 5532636
SGTC_2355 9061122 103.12 µM -1.11619525576678 0.148774380610441 no 2892 0.132169282411351 4223 5302957
SGTC_1531 st059297 52.4 µM -1.11671344863618 0.148661928455045 no 2893 0.132058432867951 4228 7566702
SGTC_962 1254-0300 21.5 µM -1.11888072054374 0.148192228355669 no 2894 0.131595514455004 4182 7340576
SGTC_3085 9117376 49.47 µM -1.11908460564674 0.148148092691163 no 2895 0.131552023326204 4305 16480349
SGTC_20 0481-0013 4.944 µM -1.12184000952753 0.147552484237698 no 2896 0.130965235695813 4244 182045
SGTC_133 0724-0033 378.92 µM -1.1244091215008 0.146998591702674 no 2897 0.130419752103622 4036 280309
SGTC_1431 4049-0260 9.09 µM -1.12601605251003 0.14665285211044 no 2898 0.130079362366814 4217 3854841
SGTC_150 3970-0969 77.2 µM -1.12667789437148 0.146510612165333 no 2899 0.129939345993667 4302 6615640
SGTC_1992 st073643 23.3 µM -1.12829197951715 0.146164108980662 no 2900 0.129598314797793 4196 3161292
SGTC_610 4215-0184 155 µM -1.1351255096498 0.144703225059476 no 2901 0.128161367302428 4241 5605015
SGTC_1247 0448-0043 5.84 µM -1.13688410878854 0.144328865296629 no 2902 0.127793368064195 4254 3089013 YGL099W LSG1
SGTC_1810 st050138 53 µM -1.13756330886562 0.144184456261161 no 2903 0.127651437445287 4232 3444541
SGTC_2120 5538279 151.968 µM -1.13832105542234 0.144023461961351 no 2904 0.127493222544454 4194 2058197
SGTC_2719 novobiocin 32.65 µM -1.13869610096008 0.143943822939157 no 2905 0.127414964781639 4268 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1631 benzylvanillin 81.9 µM -1.13998908560404 0.143669491945461 no 2906 0.127145424130644 4296 75506
SGTC_47 0149-0135 24.25 µM -1.14099542288638 0.143456222900575 no 2907 0.126935913861896 4247 5239155
SGTC_3285 9112818 20.8695 µM -1.14113838305839 0.143425943268897 no 2908 0.12690617035946 4211 17017947 YPR165W RHO1
SGTC_3109 9122853 49.47 µM -1.14267021938028 0.143101764024128 no 2909 0.126587769458048 4257 1234709
SGTC_1522 st012842 45.6 µM -1.14301285920213 0.143029319689549 no 2910 0.126516626034482 4084 3491067 YOR116C RPO31
SGTC_2537 larixol 68.93 µM -1.14340499617675 0.142946440585003 no 2911 0.126435239539788 4213 6708759
SGTC_880 0833-0487 87.2 µM -1.14468354770818 0.142676441049233 no 2912 0.126170134548825 4230 76075
SGTC_927 2425-1185 123 µM -1.14962040098687 0.141637133206124 no 2913 0.12515012590495 4174 730375
SGTC_1715 st032160 10.2275 µM -1.15021457872501 0.141512393388119 no 2914 0.125027751547293 4177 5289825
SGTC_1408 3909-7976 48.8 µM -1.15041651885651 0.141470015661791 no 2915 0.12498617984048 4290 24152374
SGTC_504 lovastatin 124 µM -1.15443905772576 0.140627665774092 no 2916 0.124160105040614 4259 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1177 0983-0204 23.6 µM -1.15446379299195 0.140622496576274 no 2917 0.124155037212093 4264 766818
SGTC_1280 0880-0253 10.1 µM -1.15619781039925 0.140260441476348 no 2918 0.123800127624512 4228 6836607
SGTC_2426 5582046 32.21 µM -1.16183262073482 0.13908829244004 no 2919 0.122651730374459 4266 2251934
SGTC_1600 coumarin 106 71.1 µM -1.1649956088113 0.138433260037395 no 2920 0.122010385160961 4322 100336 A hepatotoxic, DNA x-linker.
SGTC_1090 efavirenz 20.7 µM -1.16721717273781 0.137974448716972 no 2921 0.121561338779568 4277 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_3347 9188721 44.724 µM -1.16924796412555 0.137555945341643 no 2922 0.12115187080062 4282 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2686 alizarin 95.37 µM -1.16951655401666 0.137500659566421 no 2923 0.121097787812609 4244 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_53 0973-0023 39.979 µM -1.16973337226132 0.137456041385664 no 2924 0.121054141901183 4148 674768
SGTC_3317 9138495 8.753 µM -1.17008947508343 0.137382781827122 no 2925 0.120982481764847 4171 17020139
SGTC_325 2810-4341 181 µM -1.1728931093696 0.1368069330592 no 2926 0.120419336576226 4255 774970
SGTC_645 0845-0943 5.41 µM -1.17532662014382 0.136308444718437 no 2927 0.119932034198288 4273 1885106
SGTC_2917 7979103 53.79 µM -1.17587586306851 0.136196108109068 no 2928 0.119822242692932 4298 2980565
SGTC_655 k060-0012 42 µM -1.17774892255484 0.135813487945424 no 2929 0.119448358434166 4252 5994525
SGTC_2656 pseudo-anisatin 100 µM -1.18155525387913 0.135038217388497 no 2930 0.118691108566024 4312 6708809 A neurotoxin.
SGTC_2640 pentamidine 10.38 µM -1.18170216701802 0.135008355192735 no 2931 0.118661949094527 4252 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_996 3970-0799 1.8 µM -1.18206608563789 0.134934403036828 no 2932 0.118589739949825 4265 6615648 YGL040C HEM2
SGTC_3057 9095946 49.47 µM -1.18261278383725 0.134823360348471 no 2933 0.118481321842747 4305 24540043
SGTC_752 1896-0090 130 µM -1.18270417813592 0.134804802899923 no 2934 0.118463203877079 4261 772567
SGTC_1395 3486-0190 4.35 µM -1.18345293697876 0.134652834751905 no 2935 0.118314843988893 4257 6748079
SGTC_2147 5545932 89.7195 µM -1.18653533541707 0.134028469486762 no 2936 0.117705477812386 4306 797404
SGTC_807 1315-0151 48 µM -1.18802783850992 0.133726866540922 no 2937 0.117411221076093 4313 4011080
SGTC_1199 1638-0010 4.46 µM -1.18859708771822 0.133611956464319 no 2938 0.117299127218844 4244 3111136
SGTC_2271 7849410 118.62 µM -1.19105716444814 0.133116140044009 no 2939 0.116815572202499 4216 972430
SGTC_189 3970-0742 2.116 µM -1.19171488170237 0.132983795162865 no 2940 0.116686530415709 4252 2891807
SGTC_1619 st003326 88.7 µM -1.19420116205051 0.132484328095777 no 2941 0.116199644327167 4272 2849032
SGTC_2653 dihydrofissinolide 100 µM -1.19648927399368 0.132025814459695 no 2942 0.115752840897723 4323 6857746
SGTC_503 tyrphostin 8 294 µM -1.19673923764246 0.131975790752906 no 2943 0.115704104110385 4288 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2374 9071832 200 µM -1.1987348035295 0.131576899031433 no 2944 0.115315540264642 4212 17381698
SGTC_62 0180-0423 3.232 µM -1.20071197162129 0.13118250625483 no 2945 0.114931474316331 4261 30102 YGL099W LSG1
SGTC_2327 6189656 200 µM -1.20299577033162 0.130727965981901 no 2946 0.11448897866524 4364 5349088
SGTC_846 0335-0850 148 µM -1.20380362297664 0.130567441530755 no 2947 0.114332744532047 4258 6819598
SGTC_2893 9048488 25.97 µM -1.20432601892796 0.130463711378816 no 2948 0.114231796964065 4332 6467338
SGTC_1951 sophoraflavanone G 9.2 µM -1.20540397198197 0.130249846574206 no 2949 0.114023694440214 4244 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1211 1056-0033 32.3 µM -1.20707235206021 0.129919320092921 no 2950 0.113702140698366 4346 6741922
SGTC_1588 farnesol 29.9 µM -1.2095909626272 0.129421453299082 no 2951 0.113217943839378 4304 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_934 2950-0684 338 µM -1.21282560329879 0.128783986533366 no 2952 0.112598252172061 4324 1121253
SGTC_1078 idebenone 36.1 µM -1.21604262517958 0.128152155721521 no 2953 0.11198434244594 4343 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1562 morin hydrate 59.1 µM -1.21652905895568 0.128056806665196 no 2954 0.111891724158015 4333 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2575 plumbagin 510 nM -1.21745159082519 0.127876110561161 no 2955 0.111716222115583 4204 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2652 actinonin 100 µM -1.21884977200887 0.127602587022173 no 2956 0.111450608287093 4331 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2310 7668677 200 µM -1.21958212472426 0.127459480684448 no 2957 0.11131166303818 4317 2197143
SGTC_944 3370-0224 231 µM -1.221147054321 0.127154057735841 no 2958 0.111015173252884 4309 4580514
SGTC_2338 7999974 200 µM -1.22120188523903 0.127143365779853 no 2959 0.111004795315405 4295 315925
SGTC_3291 9121177 71.43 µM -1.2230402036826 0.126785258164811 no 2960 0.110657255875038 4285 17015612
SGTC_1955 wogonin 32.4 µM -1.22369364736035 0.126658135547772 no 2961 0.110533908507393 4350 5281703 A flavanone.
SGTC_2117 5521686 200 µM -1.22920483639224 0.125589505757618 no 2962 0.109497508031846 4287 803312
SGTC_850 0388-0143 75.9 µM -1.22963351872739 0.12550664795978 no 2963 0.109417186166406 4289 67273
SGTC_329 k048-0121 21.3 µM -1.2303896260868 0.125360596869915 no 2964 0.109275618102167 4331 6832902
SGTC_2516 gossypol 71.55 µM -1.2383544322829 0.123829305650596 no 2965 0.107792334457606 4335 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_186 3455-3465 67.277 µM -1.23919208966136 0.123669024230271 no 2966 0.107637184666111 4329 755278
SGTC_785 1270-0111 65.3 µM -1.24041138412153 0.123435978234881 no 2967 0.107411636217456 4242 6741994
SGTC_451 chloral hydrate 100 µM -1.24158805723741 0.123211370391562 no 2968 0.107194295187455 4331 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_11 0438-0307 1.3 µM -1.24226964623165 0.123081397170488 no 2969 0.107068545330763 4316 4011476
SGTC_470 aa-861 153 µM -1.24435159657546 0.122684982188558 no 2970 0.106685094533504 4277 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1179 1021-1431 9.29 µM -1.2502869995302 0.121559767285282 no 2971 0.105597362867611 4335 2840958
SGTC_2126 5251174 33.877 µM -1.25318112363885 0.121013747141737 no 2972 0.105069898994907 4331 790722
SGTC_3024 9090631 49.47 µM -1.25337749152935 0.120976761991313 no 2973 0.105034179491678 4293 25236383
SGTC_2113 5491891 107.031 µM -1.25526139288338 0.12062234042402 no 2974 0.104691942651017 4321 789979
SGTC_1826 st055655 41.6 µM -1.2554222172997 0.120592118156168 no 2975 0.104662764121987 4347 676168
SGTC_3102 9121669 49.47 µM -1.2586402343848 0.119988505938114 no 2976 0.104080153776094 4378 41905072
SGTC_1401 3807-4679 7.6 µM -1.26267249641406 0.119235173852446 no 2977 0.103353451096299 4256 3291456
SGTC_1399 3562-5772 25 µM -1.2641784120008 0.118954687395586 no 2978 0.103082998743068 4323 23847490
SGTC_898 1000-0849 28.3 µM -1.26542700180158 0.118722483089101 no 2979 0.10285915044176 4351 6751807
SGTC_618 k072-0232 33.2 µM -1.26730231526682 0.118374326910883 no 2980 0.10252360649491 4387 5872756 YGL099W LSG1
SGTC_495 decylubiquinone 155 µM -1.26764058628379 0.118311603046746 no 2981 0.102463165540399 4353 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2146 5545642 200 µM -1.27086018491066 0.117715785285674 no 2982 0.101889196510061 4300 825326
SGTC_171 k064-0041 9.68 µM -1.27109740622827 0.117671969343171 no 2983 0.101846998989965 4334 53325
SGTC_78 0336-0123 156.75 µM -1.27245799750598 0.117420884422305 no 2984 0.101605219309494 4179 6765896
SGTC_847 0342-0274 5.54 µM -1.27248063216285 0.117416710609925 no 2985 0.101601200624996 4346 18097
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.27519246943327 0.116917410102602 no 2986 0.101120563041116 4375 688664
SGTC_2596 sinensetin 100 µM -1.2774563375806 0.11650174315215 no 2987 0.100720592935467 4358 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_248 streptozotocin 5.23457 mM -1.28022191759849 0.11599538102847 no 2988 0.100233549857227 4384 5300 DNA alkylating agent.
SGTC_1476 4112-3294 3.34 µM -1.28183322725096 0.115701080653975 no 2989 0.099950577761379 4338 704369
SGTC_1710 st031758 61.5 µM -1.28827895453669 0.114529095286653 no 2990 0.0988244381723124 4392 5394341
SGTC_704 1310-0270 142 µM -1.28841830667994 0.114503851434251 no 2991 0.0988001947701519 4361 5718033
SGTC_715 0868-0130 184 µM -1.28874570279664 0.114444558714275 no 2992 0.0987432540640758 4408 2876258
SGTC_220 paclitaxel 373.376 µM -1.2889710059165 0.11440376813429 no 2993 0.0987040833164454 4315 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_553 k007-0256 45.7 µM -1.28969911454961 0.114272016620696 no 2994 0.0985775735777385 4415 6287000
SGTC_1160 4092-0570 10.5 µM -1.29254516296854 0.113758059829268 no 2995 0.0980842080697847 4354 4994975
SGTC_3012 9080433 71.4286 µM -1.29662316442404 0.113024504468308 no 2996 0.0973804390786085 4359 17688859
SGTC_2607 solasodine 47.35 µM -1.29931342831276 0.112542428726099 no 2997 0.0969181939222666 4335 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2018 5133068 143 µM -1.29945716551123 0.112516713459317 no 2998 0.0968935421939063 4328 785362
SGTC_3035 9091303 49.47 µM -1.30123301691576 0.112199351434831 no 2999 0.0965893535248206 4437 25237002
SGTC_2724 maprotiline 69.64 µM -1.30474984910751 0.111572748285945 no 3000 0.0959890205814015 4308 4011 A tricyclic antidepressant.
SGTC_3059 1327-0034 3 µM -1.30600455971236 0.111349800383399 no 3001 0.0957755034817918 4213 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1561 5-methoxyflavone 52.9 µM -1.30732292382338 0.111115885731897 no 3002 0.0955515309567735 4336 94525
SGTC_2807 7945238 51.95 µM -1.31105778103661 0.110455128672896 no 3003 0.0949191214995182 4364 17148797
SGTC_1235 benzylparaben 21.5 µM -1.31119750564304 0.11043046389681 no 3004 0.094895522436533 4400 7180
SGTC_483 fpl-64176 144 µM -1.31605792097444 0.10957493939047 no 3005 0.0940773014385273 4509 3423
SGTC_873 0591-4978 488 µM -1.31907773720665 0.109045797806007 no 3006 0.0935715625464317 4427 3305145
SGTC_2089 5281248 129.67 µM -1.31934542657299 0.108998981209775 no 3007 0.0935268287585295 4372 2737878
SGTC_1969 st069479 40.1 µM -1.31946789931859 0.108977566584664 no 3008 0.0935063675051943 4379 3895485
SGTC_2566 crystal violet carbinol 226 nM -1.32057925329494 0.108783382154702 no 3009 0.0933208471266373 4369 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_84 0443-0269 128.823 µM -1.32073224317956 0.10875667006436 no 3010 0.093295329550616 4301 6150058
SGTC_2075 5212009 200 µM -1.32481442845907 0.108045660213499 no 3011 0.0926163540331744 4313 780898
SGTC_1007 4101-0031 70 µM -1.32523512237932 0.10797257700794 no 3012 0.0925465897843808 4372 1146276
SGTC_1569 carminic acid 40.6 µM -1.32532168048454 0.107957544497424 no 3013 0.0925322405588397 4459 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_33 0986-0033 35.816 µM -1.33169268097851 0.106855229988253 no 3014 0.0914805976499122 4346 2848082
SGTC_1410 3909-8106 77.9 µM -1.34440062122827 0.104680796013183 no 3015 0.0894094365262478 4442 1039210
SGTC_3250 9135583 49.47 µM -1.34636777961421 0.104347083953371 no 3016 0.0890919683405585 4417 7699353
SGTC_838 0109-0203 71.4 µM -1.34683468756973 0.104267990236437 no 3017 0.0890167401395645 4419 759422
SGTC_298 1391-0729 10 µM -1.34740551143351 0.104171352320881 no 3018 0.0889248332597099 4342 3237558
SGTC_1437 4092-1038 11.6 µM -1.34837928597437 0.104006646551183 no 3019 0.088768211403784 4464 3977136
SGTC_1010 4112-3296 15.2 µM -1.34872690202583 0.103947895982231 no 3020 0.0887123506353124 4433 704384
SGTC_407 eburnamonine 100 µM -1.35027157715591 0.103687121605332 no 3021 0.0884644429735983 4252 3195
SGTC_1107 amlodipine 47 µM -1.35140962665551 0.103495298278271 no 3022 0.0882821258777067 4016 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3302 9125395 16.351 µM -1.35363783701425 0.103120469547757 no 3023 0.0879259746533017 4348 17599668
SGTC_3275 9138069 49.47 µM -1.35793117094917 0.10240102835094 no 3024 0.0872427626913633 4471 17617007
SGTC_713 1488-1073 324 µM -1.35987521664368 0.102076464584166 no 3025 0.0869347074428404 4439 3312542
SGTC_1720 st037298 9.481 µM -1.36349522549811 0.101474089906242 no 3026 0.0863632440861808 4400 597396
SGTC_776 4476-4378 112 µM -1.36577645790745 0.101095821847816 no 3027 0.0860045688767622 4464 2892008
SGTC_3110 9122132 49.47 µM -1.37101677353443 0.100230780406972 no 3028 0.0851848636256133 4449 918317
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.37690118444939 0.0992658695171493 no 3029 0.0842714004854167 4415 15053
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.37714253570485 0.0992264388522537 no 3030 0.0842340920209124 4416 641818 YHR062C RPP1
SGTC_2218 6965428 192.983 µM -1.37791353585524 0.0991005537443557 no 3031 0.0841149926358706 4323 675684
SGTC_823 0417-1665 178 µM -1.37806377068531 0.0990760377449063 no 3032 0.084091800002361 4427 3429856
SGTC_1760 st045453 10.4495 µM -1.38014864579805 0.0987362762043452 no 3033 0.0837704409960806 4452 3323419 YIL048W NEO1
SGTC_3352 9151559 45.5865 µM -1.38090220179185 0.0986136830377013 no 3034 0.0836545164410009 4437 17159339
SGTC_1147 3809-1045 12.3 µM -1.38223566969084 0.0983970193041152 no 3035 0.0834496755691983 4423 325925
SGTC_1716 st033144 30.6155 µM -1.38888762285623 0.0973214059645876 no 3036 0.0824334623938641 4418 674617
SGTC_2772 vinpocetine 57.06 µM -1.39166925891745 0.096874185498954 no 3037 0.0820112876806276 4442 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2197 6588183 93.1375 µM -1.39833803075659 0.0958081554134855 no 3038 0.0810057912843967 4430 884136
SGTC_3087 9117406 49.47 µM -1.39936024247192 0.0956455164365243 no 3039 0.0808524914106789 4448 42546093
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.40486735788389 0.0947728012061859 no 3040 0.0800303623593789 4506 4620898
SGTC_200 k038-0079 37.545 µM -1.40782253928974 0.0943069184286021 no 3041 0.0795918122486853 4439 3436683
SGTC_1156 4092-0367 4.88 µM -1.40993836176181 0.0939743992124903 no 3042 0.0792789420261254 4486 1357585
SGTC_2362 9071156 126 µM -1.41779558070063 0.0927471431565057 no 3043 0.0781252273962833 4452 653133
SGTC_2191 5911152 200 µM -1.41851387411718 0.092635543600001 no 3044 0.0780203954855977 4470 2875902
SGTC_680 0417-1641 114 µM -1.42095551474589 0.0922569343120358 no 3045 0.0776648461922111 4467 2835990
SGTC_2972 9093619 59.92 µM -1.42442267715185 0.0917212737205882 no 3046 0.0771620767820864 4402 25236256
SGTC_147 4466-0538 29.23 µM -1.42727473756635 0.091282373596688 no 3047 0.0767503596613827 4504 6742687 YHR072W ERG7
SGTC_506 n9-isopropylolomoucine 153 µM -1.42822914346353 0.0911358495015863 no 3048 0.0766129574115349 4444 6610355
SGTC_2259 7964009 200 µM -1.43227407540596 0.0905167916905093 no 3049 0.0760326996909314 4467 313134
SGTC_3243 9134147 49.47 µM -1.43233821644694 0.0905070004128039 no 3050 0.0760235254886702 4542 24282180
SGTC_3353 9151644 39.2805 µM -1.43430686170593 0.0902068644868111 no 3051 0.0757423565241289 4463 4909158
SGTC_2525 harmine 47.85 µM -1.43700937208291 0.0897960498199602 no 3052 0.0753576652740602 4436 5280953 A monoamine oxidase inhibitor
SGTC_2119 5528445 120.635 µM -1.43839175866576 0.0895864485248124 no 3053 0.0751614648347494 4489 791935
SGTC_1782 st039423 80.636 µM -1.44012198328412 0.089324619973457 no 3054 0.074916445298689 4469 2068169
SGTC_34 0469-0683 81.75 µM -1.44807282949056 0.0881287631582922 no 3055 0.0737983417050061 4430 3690923
SGTC_982 1491-0518 27.5 µM -1.44815049828621 0.0881171404426707 no 3056 0.0737874826277054 4412 3091256
SGTC_603 3794-0023 45.9 µM -1.44842776355785 0.0880756585139486 no 3057 0.0737487274070143 4500 3802260
SGTC_1467 k284-1082 293 µM -1.44848986185016 0.0880663699235263 no 3058 0.0737400496464982 4431 3334705
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.45293204167157 0.0874038070966894 no 3059 0.0731213117651989 4510 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_68 0986-0284 82.829 µM -1.45457811107852 0.0871592386537928 no 3060 0.072893047223073 4451 423278 YIL048W NEO1
SGTC_2203 7227154 166.4 µM -1.459948377166 0.0863648925482103 no 3061 0.0721521310644216 4500 896304
SGTC_2481 5478948 45.16 µM -1.46065250009548 0.0862611445104914 no 3062 0.0720554153630474 4463 77792
SGTC_629 3448-6466 76.7 µM -1.46148940157279 0.0861379536673345 no 3063 0.0719405909989155 4481 573744
SGTC_530 4358-1714 28 µM -1.46355773860817 0.0858340616885821 no 3064 0.0716574133962317 4450 1564641
SGTC_1080 nisoldipine 24.4 µM -1.4655384867694 0.0855437916499305 no 3065 0.0713870299890556 4483 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1950 st077106 7.18 µM -1.46667365646895 0.0853777691563636 no 3066 0.071232426229215 4379 13831864
SGTC_1248 0469-0687 58.6 µM -1.46926744786043 0.0849993241801913 no 3067 0.0708801312049937 4441 4017482
SGTC_2446 5162541 200 µM -1.47191320924903 0.0846145934080587 no 3068 0.0705221580451327 4459 1549321
SGTC_1057 3448-5381 134 µM -1.47300310617815 0.0844564875268372 no 3069 0.0703750991105712 4445 5497911
SGTC_3053 9095903 49.47 µM -1.48292311087101 0.0830276182968648 no 3070 0.0690474201937727 4596 17174018
SGTC_219 mitoxanthrone 164.414 µM -1.48573519125132 0.0826258950469504 no 3071 0.0686745892115516 4434 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_3343 9148379 18.9835 µM -1.49144872598927 0.0818141893766287 no 3072 0.0679218617197962 4495 1955036
SGTC_950 1165-0508 94.1 µM -1.49343271295132 0.081533740344701 no 3073 0.067661977627228 4468 6148369
SGTC_3134 9127454 49.47 µM -1.49898602775985 0.0807525991263451 no 3074 0.066938628415235 4540 24262820
SGTC_2173 5763948 167 µM -1.49908472139821 0.0807387679545544 no 3075 0.0669258273494709 4462 2867177
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.50013671447694 0.0805914501698727 no 3076 0.066789496154038 4491 75037 A free radical scavenger.
SGTC_3249 9135183 49.47 µM -1.50277863507492 0.080222379232796 no 3077 0.0664480685413298 4460 4902779
SGTC_2751 anetholtrithion 17.25 µM -1.50770196485501 0.0795380106153294 no 3078 0.0658154112130859 4454 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1206 3978-0017 132 µM -1.50825838500157 0.0794609440044329 no 3079 0.0657442047884917 4535 3873677
SGTC_705 1124-0212 310 µM -1.51221985271495 0.0789138960789166 no 3080 0.065238971097583 4496 9554485
SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.51614418067742 0.0783747945437551 no 3081 0.0647414494331315 4518 140250 A respiratory chain inhibitor.
SGTC_3005 9076496 71.4286 µM -1.51632890730207 0.0783494868548198 no 3082 0.0647181028213568 4474 21368410
SGTC_2604 4'-hydroxychalcone 11.32 µM -1.51707502930528 0.0782473306260953 no 3083 0.0646238709749567 4491 5282362
SGTC_1348 1493-0373 93.8 µM -1.51864824954628 0.0780322623029977 no 3084 0.0644255296262616 4529 3010129
SGTC_2826 7992541 19.48 µM -1.51919932477343 0.077957033283424 no 3085 0.0643561656210565 4502 2985066
SGTC_2815 7968870 71.43 µM -1.52184547338004 0.077596565569697 no 3086 0.0640239021730422 4429 2977326 YHR190W ERG9
SGTC_159 3970-0959 50 µM -1.52206901635857 0.0775661718218515 no 3087 0.0639958942276149 4522 6615653
SGTC_3104 9120930 49.47 µM -1.52295538230126 0.0774457471343055 no 3088 0.0638849342355397 4536 17014836
SGTC_2188 6126565 140.678 µM -1.52477061970226 0.0771995660513503 no 3089 0.0636581602273378 4414 874518
SGTC_1352 1496-0991 99 µM -1.52701273612941 0.0768963132596302 no 3090 0.0633789221976791 4503 3000039
SGTC_441 propafenone 146 µM -1.52804109461727 0.0767575280591525 no 3091 0.0632511675773012 4492 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1494 4358-1428 177 µM -1.53314009630247 0.0760721891231242 no 3092 0.0626206700790737 4522 1564571
SGTC_3170 9103054 49.47 µM -1.53516520516365 0.075801297465197 no 3093 0.06237162641049 4480 16432970
SGTC_2427 5545055 42.75 µM -1.53542013387053 0.0757672486834945 no 3094 0.0623403306198195 4452 5372858
SGTC_1862 st057513 3.81 µM -1.54187792148873 0.0749086139011877 no 3095 0.0615516310366854 4497 5393163
SGTC_819 1013-0258 27.7 µM -1.54368839661376 0.074669228311722 no 3096 0.0613319193202545 4515 5753198
SGTC_212 3807-4682 38.772 µM -1.55067591757025 0.0737507928974193 no 3097 0.0604896842928279 4594 3125501 YBL034C STU1
SGTC_225 nsc-122657 1.016 µM -1.55294660636609 0.0734542014074215 no 3098 0.0602179455306374 4528 275685
SGTC_1651 st011928 86.1 µM -1.55754351915687 0.072856558231689 no 3099 0.0596707482820557 4537 720198
SGTC_1424 4048-1941 275 µM -1.55905801170864 0.0726604769520262 no 3100 0.0594913251866922 4593 X1424
SGTC_2016 5121758 140 µM -1.55995397616874 0.0725446668885715 no 3101 0.0593853788414242 4449 2795203
SGTC_599 1935-0052 86.5 µM -1.56108816784519 0.0723982670270243 no 3102 0.0592514747199468 4523 9557311
SGTC_2073 5212005 126 µM -1.56683414891719 0.0716600599453664 no 3103 0.0585767315368824 4445 691789
SGTC_795 0685-0265 78 µM -1.56854387997087 0.0714415230786247 no 3104 0.0583771288989448 4530 302754
SGTC_1462 k081-0014 26.5 µM -1.57033642421721 0.0712129506937585 no 3105 0.0581684322570216 3959 3270634
SGTC_2912 7964298 10.93 µM -1.57040120448052 0.0712047009035145 no 3106 0.0581609012155723 4520 2975850
SGTC_1076 itraconazole 331 nM -1.57570019027643 0.0705323548966723 no 3107 0.0575474567952654 4544 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2457 5731572 11.68 µM -1.57920771936076 0.0700900037901977 no 3108 0.0571442099700638 4583 2865357
SGTC_2584 androsterone 48.74 µM -1.59874647127389 0.0676648356554738 no 3109 0.0549384736439165 4441 2754130 A steroid.
SGTC_1648 st011736 69.8 µM -1.60870648426653 0.0664537959861849 no 3110 0.0538402686397629 4537 2855514
SGTC_665 3914-0008 307 µM -1.60901761113251 0.0664162380818817 no 3111 0.0538062454043017 4527 1069549
SGTC_984 1492-0255 2.91 µM -1.61116198644281 0.0661578251066031 no 3112 0.0535722103871451 4512 1585198
SGTC_792 4534-1957 155 µM -1.61188992314015 0.0660702806732941 no 3113 0.0534929476880561 4517 1717904
SGTC_1675 st018485 24.5 µM -1.61542463027997 0.0656464587705908 no 3114 0.0531093849781351 4541 3323024
SGTC_1966 st070145 16.1 µM -1.6250448882593 0.0645036345758653 no 3115 0.0520764972722315 4532 3748532
SGTC_2712 st079126 47.7 µM -1.626128160144 0.0643759231016025 no 3116 0.0519611973172865 4556 3152970
SGTC_2464 5717415 7.67 µM -1.6269569346013 0.0642783481302962 no 3117 0.0518731222721404 4527 5285744
SGTC_2929 9013348 24.6 µM -1.63495779574819 0.0633422758369648 no 3118 0.0510289476350519 4533 2995952
SGTC_379 3970-0972 5.9 µM -1.63841238510624 0.0629413960895466 no 3119 0.0506678486441806 4571 2898042 YBL034C STU1
SGTC_1920 st075728 45.7 µM -1.63952924691548 0.0628122161166657 no 3120 0.0505515423751546 4539 3400306
SGTC_990 3985-0011 41.3 µM -1.64017220721318 0.0627379429301634 no 3121 0.0504846831515083 4531 5399565 YGL099W LSG1
SGTC_1145 3546-0597 10.2 µM -1.64196974969636 0.0625306583908197 no 3122 0.0502981366696555 4549 875334
SGTC_1143 3454-2408 5.08 µM -1.64342844357898 0.0623628411059794 no 3123 0.0501471595696544 4563 X1143
SGTC_493 zm226600 134 µM -1.64578297827466 0.0620927019329571 no 3124 0.0499042239924403 4570 5240098 A potassium channel opener. YCR052W RSC6
SGTC_17 0960-0276 49.807 µM -1.64734194419228 0.0619143424681542 no 3125 0.0497438905474515 4563 6821114
SGTC_3339 9145883 14.936 µM -1.64940627153329 0.0616787807774452 no 3126 0.0495322153777091 4488 2030670
SGTC_1125 tnp00248 1.32998 µM -1.65598903453205 0.0609322889755112 no 3127 0.0488620197365174 4591 24207736
SGTC_2211 7117706 200 µM -1.65761783908112 0.0607486754428352 no 3128 0.0486973133414798 4549 822771
SGTC_762 1165-0429 115 µM -1.65969083549434 0.0605156147508229 no 3129 0.0484883319823454 4572 5967793
SGTC_1323 1348-1351 11.2 µM -1.66548850310624 0.0598675139505913 no 3130 0.0479076677286767 4565 6989654
SGTC_2416 tofa 880 nM -1.66910809785254 0.0594656570751329 no 3131 0.0475479793732906 4526 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_810 3825-7150 143 µM -1.67438298513624 0.0588838149304804 no 3132 0.0470276772964758 4585 22330411 YGL099W LSG1
SGTC_1060 3448-7350 82 µM -1.67574270587691 0.0587345585647075 no 3133 0.0468943004628251 4536 570178
SGTC_1326 1431-2094 10.8 µM -1.67651489813752 0.0586499274197943 no 3134 0.0468186902629889 4591 616278
SGTC_2907 7721985 69.9 µM -1.67869536162419 0.0584114685481092 no 3135 0.0466057152003437 4576 3267881
SGTC_1607 st000305 50.6 µM -1.68036769572098 0.0582290959485232 no 3136 0.0464428986362554 4584 5457690
SGTC_1775 st081588 35.1725 µM -1.68606571139319 0.057611068666068 no 3137 0.0458915717039593 4560 1426443 YGL099W LSG1
SGTC_1622 st003707 19.4 µM -1.69010505043948 0.0571760808996949 no 3138 0.0455039294250462 4594 10140899
SGTC_2343 7990716 14.84 µM -1.6908015195814 0.0571013415934436 no 3139 0.0454373584389996 4593 6456862
SGTC_254 nsc-64875 3.808 µM -1.69106907046209 0.0570726507012791 no 3140 0.0454118058116559 4590 56993
SGTC_1628 st004252 77.7 µM -1.6933685951292 0.056826528235777 no 3141 0.0451926643856051 4578 692968
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.69542254218178 0.0566073978881827 no 3142 0.0449976463125549 4600 5393153
SGTC_1172 0370-0043 85 µM -1.69699718893047 0.0564398541438614 no 3143 0.044848595995651 4606 376585
SGTC_1504 k297-0033 30 µM -1.70028413382237 0.0560913799462473 no 3144 0.0445387466878752 4497 4388117
SGTC_657 3534-0529 86.7 µM -1.70105953114337 0.0560094219965933 no 3145 0.0444659045398878 4604 1049549
SGTC_292 k038-0015 474 µM -1.70231956525141 0.0558764403935498 no 3146 0.0443477395340265 4582 46368540
SGTC_2871 9038510 12.99 µM -1.70334073295545 0.0557688511372668 no 3147 0.0442521609909219 4541 4945164
SGTC_3227 9130768 49.47 µM -1.70390042539822 0.0557099518628871 no 3148 0.0441998457691367 4654 17720899
SGTC_110 0850-0284 111.64 µM -1.70583072125806 0.0555071935740646 no 3149 0.0440198007336685 4538 3906265
SGTC_1477 0139-0234 16 µM -1.71202042257224 0.0548609544161368 no 3150 0.0434464524603921 4611 620880
SGTC_1908 st060353 56.5 µM -1.71377615903702 0.0546787325288038 no 3151 0.0432849217755212 4585 4227716
SGTC_2777 climbazole 1.536 µM -1.71580934170651 0.0544683137534853 no 3152 0.043098471912036 4396 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_3129 9127257 49.47 µM -1.71740223779204 0.0543039091152211 no 3153 0.0429528515420461 4534 837894
SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.71938499738196 0.0540998149966899 no 3154 0.0427721460916473 4619 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2943 9068529 45.32 µM -1.72054092123592 0.0539811111246747 no 3155 0.0426670809597215 4556 3270634
SGTC_1492 4158-0558 28.5 µM -1.72693150467841 0.0533285674642518 no 3156 0.0420899827820286 4614 3967268
SGTC_2155 5570423 76 µM -1.73781440315545 0.0522317178341973 no 3157 0.0411217609703348 4600 797402
SGTC_835 0312-0010 67.2 µM -1.73838950065753 0.0521742578918332 no 3158 0.0410711027308548 4638 1626196
SGTC_344 k064-0035 6.43 µM -1.74186060397193 0.0518285134452629 no 3159 0.0407664194948294 4552 5088750
SGTC_330 1488-0319 80.1 µM -1.74556965731095 0.0514610826298986 no 3160 0.0404428792966613 4625 6846614
SGTC_2551 apiole 73.87 µM -1.75861913510661 0.0501847997665747 no 3161 0.0393211103191131 4556 10659 A possible DNA adduct former.
SGTC_231 b-estradiol 524 µM -1.76486241325955 0.0495831748118592 no 3162 0.0387934460253672 4625 450 A steroid.
SGTC_1985 st071382 65.5 µM -1.76661810690045 0.0494150307161612 no 3163 0.038646103246611 4614 6123237
SGTC_1640 st009078 66.4 µM -1.77671853922658 0.0484565285324968 no 3164 0.0378072802276879 4603 690618
SGTC_149 3970-0822 46.1 µM -1.79149722995149 0.0470809288184494 no 3165 0.0366067693610079 4599 3114250 YBL034C STU1
SGTC_2458 5808907 16.39 µM -1.7935186238202 0.0468952359590513 no 3166 0.0364450177171885 4708 2731747
SGTC_2546 rhodinyl acetate 100 µM -1.79484443757368 0.0467737610191413 no 3167 0.0363392442558179 4573 6708682
SGTC_1657 st012939 43.4 µM -1.79645625866148 0.0466264213711234 no 3168 0.03621099168228 4623 24207257
SGTC_548 1436-0017 110 µM -1.80918828269667 0.0454756118014322 no 3169 0.035210878683503 4651 9677137
SGTC_471 1-acyl-paf 4 µM -1.80984421324495 0.0454169484715696 no 3170 0.0351599746637722 4604 16759367
SGTC_1928 4'-methoxychalcone 40.3 µM -1.8196883982899 0.0445438208669365 no 3171 0.0344032355488667 4623 641818
SGTC_1163 k060-0048 49.9 µM -1.82359286282907 0.0442012824009671 no 3172 0.0341068231935979 4646 6809982
SGTC_2049 5262831 67.185 µM -1.8265936614588 0.043939468179395 no 3173 0.0338804435620223 4603 763417
SGTC_837 0091-0265 12.5 µM -1.82751033573627 0.0438597398732597 no 3174 0.0338115368044957 4646 759367
SGTC_492 tmb-8 126 µM -1.82832153490301 0.0437892826919063 no 3175 0.0337506548508384 4669 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_781 4335-2806 94.4 µM -1.83496049061878 0.043216077936114 no 3176 0.0332557718611728 4657 845254
SGTC_531 3788-1495 174 µM -1.83573239071335 0.0431498274434978 no 3177 0.0331986224905512 4626 2896655
SGTC_1470 k295-0292 231 µM -1.83791153536651 0.0429632388394361 no 3178 0.0330377210201758 4692 5045612
SGTC_714 4296-0578 26.1 µM -1.8395702265282 0.042821651326643 no 3179 0.0329156794361106 4672 1589775
SGTC_348 k064-0012 10.7 µM -1.84540200856717 0.0423268360014643 no 3180 0.0324895405941167 4619 5066323
SGTC_1819 st053448 58.6 µM -1.84896098375829 0.042027143572299 no 3181 0.0322317233662741 4602 2857616
SGTC_2497 7-hydroxyflavone 100 µM -1.85139089291762 0.0418235154115712 no 3182 0.0320566691533339 4632 5281894
SGTC_484 loperamide 105 µM -1.86003413511884 0.0411056720071458 no 3183 0.0314403483256716 4733 3955 An opioid-receptor agonist.
SGTC_597 k018-0003 82.8 µM -1.87468723194797 0.0399115456151858 no 3184 0.0304178822240206 4696 6786234
SGTC_1191 1487-1166 10.6 µM -1.87801840402051 0.0396440495174484 no 3185 0.0301893237278595 4660 3955771
SGTC_1070 indatraline 8.81 µM -1.87931716425131 0.0395401537133257 no 3186 0.0301005996999018 4688 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_701 4424-0219 185 µM -1.88065150506164 0.0394336423563224 no 3187 0.0300096702636987 4661 2911779
SGTC_1896 st058441 89 µM -1.88074862942425 0.0394258987006065 no 3188 0.03000306056981 4653 688759
SGTC_2792 7535235 81.82 µM -1.88077795183028 0.0394235610893591 no 3189 0.0300010653023156 4601 1281891
SGTC_2244 6635614 200 µM -1.88548389545077 0.0390498572726327 no 3190 0.0296822683562648 4626 836499
SGTC_3300 9124615 50.48 µM -1.88840892830537 0.0388190343412705 no 3191 0.0294855368295117 4646 24824903
SGTC_2260 7964312 200 µM -1.89314406193033 0.0384477276907277 no 3192 0.029169356971963 4671 231951
SGTC_1796 st049173 110.4 µM -1.89563295104228 0.0382537245921787 no 3193 0.0290042984683619 4646 94134
SGTC_2299 7976368 114.88 µM -1.90009459759819 0.0379079480333428 no 3194 0.0287103532753145 4638 2979718
SGTC_3143 9086658 49.47 µM -1.90063949213522 0.0378658941367308 no 3195 0.0286746245029636 4613 25236626
SGTC_769 0302-0231 76 µM -1.91892461058795 0.0364766149145759 no 3196 0.027496937753138 4598 571869 YER009W NTF2
SGTC_363 0455-0021 3.06 µM -1.93214746197262 0.0354981731853298 no 3197 0.0266706538223827 4600 4597466
SGTC_3266 9136860 49.47 µM -1.93472243702547 0.0353101605118382 no 3198 0.0265121827613937 4428 4871271 YPR165W RHO1
SGTC_1305 1181-0477 144 µM -1.93896594298531 0.0350021021018404 no 3199 0.0262527426459816 4694 6252086
SGTC_2587 piperic acid 92.2 µM -1.94040394907059 0.0348982114000959 no 3200 0.0261653085229718 4620 5370536
SGTC_499 genistein 192 µM -1.94224116496518 0.0347658476732318 no 3201 0.0260539559138725 4724 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1641 st009299 47.1 µM -1.94321295418106 0.0346960011813038 no 3202 0.0259952167737589 4628 4046054
SGTC_892 0929-0076 29 µM -1.94476318731002 0.034584818119217 no 3203 0.0259017433143078 4669 5751038
SGTC_2003 4023581 200 µM -1.95013312955067 0.0342019452134768 no 3204 0.0255801267349516 4654 16641307
SGTC_1691 st019933 84.6 µM -1.96012497239474 0.0334988088644811 no 3205 0.0249905925378838 4668 6176082
SGTC_2414 st077232 92.9 µM -1.96618285195661 0.0330783344284378 no 3206 0.0246387462845649 4618 729801
SGTC_445 e6 berbamine 66 µM -1.96986455172645 0.0328249207351263 no 3207 0.0244269480151069 4676 6610268 A calcium/calmodulin antagonist.
SGTC_2627 acetyl isogambogic acid 100 µM -1.97645027033296 0.0323756141530805 no 3208 0.0240519013917593 4671 6857789 A caspase activator and apoptosis inducer.
SGTC_3251 9135047 49.47 µM -1.98670336494871 0.0316862125922396 no 3209 0.0234776393581222 4710 17682963
SGTC_2982 9019404 25.97 µM -1.98773255338996 0.0316176865836977 no 3210 0.0234206382996208 4626 22333232
SGTC_2997 9067075 71.4286 µM -1.98867702018257 0.0315549093713805 no 3211 0.023368432010594 4648 27209819
SGTC_1312 1218-2183 165 µM -1.99080501590935 0.0314138423762564 no 3212 0.0232511638588054 4725 6744073
SGTC_3337 9144342 33.5465 µM -1.9910055953291 0.0314005726947535 no 3213 0.0232401360541378 4675 17682949
SGTC_650 1328-0195 38 µM -1.9926662316593 0.0312908883281155 no 3214 0.0231490037088355 4679 2780821
SGTC_1924 st058459 75.1 µM -2.00402380680341 0.0305491901489511 no 3215 0.0225337551411222 4666 688683
SGTC_1298 1079-1278 263 µM -2.00786907533453 0.0303014012443415 no 3216 0.0223286030758324 4664 2840950
SGTC_1100 amiodarone 5.07 µM -2.00873613836815 0.0302457584867074 no 3217 0.0222825620180561 4699 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_952 1185-0122 232 µM -2.01154880039565 0.0300658418220826 no 3218 0.0221337605854459 4643 678600
SGTC_2334 9017922 200 µM -2.01325805354642 0.0299569406855174 no 3219 0.0220437443667563 4679 3163164
SGTC_221 trifluoperazine 10.304 µM -2.01563902018992 0.0298057882732034 no 3220 0.0219188682010119 4675 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2816 7982706 58.44 µM -2.02007322894667 0.0295259749569199 no 3221 0.0216878961334437 4653 2981853
SGTC_40 0327-0103 19.753 µM -2.03018385927545 0.028896108242874 no 3222 0.021168926940638 4552 409036
SGTC_1316 1272-0050 65.9 µM -2.03868243444008 0.0283753452789424 no 3223 0.0207408659875313 4702 7340392
SGTC_3145 9085516 49.47 µM -2.04303438368906 0.0281117112277013 no 3224 0.020524517263593 4663 25236195
SGTC_2138 5575593 77.673 µM -2.04820197781703 0.0278013185092291 no 3225 0.0202701063712931 4707 762213
SGTC_3212 9128307 49.47 µM -2.05726110306301 0.0272640717888238 no 3226 0.0198305583781599 4592 27243542
SGTC_2872 9044037 25.97 µM -2.05771852622686 0.0272371758341936 no 3227 0.0198085804595659 4732 6465195
SGTC_1141 3253-0389 52.6 µM -2.06702398298303 0.0266948130477602 no 3228 0.0193659470701814 4695 5402031
SGTC_3256 9138902 49.47 µM -2.07545674456382 0.0262111343267051 no 3229 0.0189721118969232 4770 17228773
SGTC_266 formosanin C 406 nM -2.0829102984586 0.0257897414480253 no 3230 0.0186297003622854 4573 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_569 4130-2812 160 µM -2.0953159545918 0.0251009539187723 no 3231 0.0180714575582683 4651 743552
SGTC_1310 1188-0297 994 nM -2.09625870209684 0.0250492470655051 no 3232 0.0180296240429867 4623 1588352
SGTC_3311 9131146 2.8755 µM -2.09772293608135 0.0249691153066038 no 3233 0.0179648137761361 4679 4900406 YPR165W RHO1
SGTC_601 0986-0029 62.9 µM -2.11739550751407 0.0239131941446958 no 3234 0.0171131475809962 4674 24747981
SGTC_1549 4'-methoxyflavonol 74.6 µM -2.1179961635123 0.0238815537367156 no 3235 0.0170876962998451 4713 97141
SGTC_3038 9091290 49.47 µM -2.11982850145139 0.0237852500564518 no 3236 0.0170102553884908 4702 25236843
SGTC_1808 st050063 61.5 µM -2.13055768420012 0.0232278779796503 no 3237 0.0165627994103904 4686 4011993
SGTC_16 erodoxin 22.806 µM -2.13067952720532 0.0232216120242457 no 3238 0.0165577764121176 4739 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_251 melphalan 456.522 µM -2.13132936786387 0.0231882170417851 no 3239 0.0165310086369866 4736 460612 A DNA alkylator.
SGTC_2758 dehydroepiandrosterone 69.35 µM -2.14163800333463 0.0226638463225606 no 3240 0.0161113115629745 4670 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3326 9140064 16.379 µM -2.14913269818084 0.0222889183984486 no 3241 0.015811941210976 4679 1868434
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -2.16309490798136 0.0216043960789666 no 3242 0.0152669403374704 4714 5024745
SGTC_1269 0831-0796 3.05 µM -2.16384832981089 0.021567969013284 no 3243 0.0152379957825554 4715 927758
SGTC_137 0438-0332 85.389 µM -2.17189380853388 0.0211822057340631 no 3244 0.014931836798724 4665 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_942 3253-1115 227 µM -2.17387339246635 0.0210881887519169 no 3245 0.0148573223931381 4716 46497897
SGTC_1965 Pectolinarigenin 58.4 µM -2.17856575212722 0.020866742542132 no 3246 0.0146819713471508 4710 5320438 An anti-inflammatory.
SGTC_1084 voriconazole 435 nM -2.18098433444542 0.0207533734475028 no 3247 0.0145922875974379 4741 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2779 methotrexate 400 µM -2.18302505184763 0.0206581225722655 no 3248 0.01451698259457 4690 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1898 st060199 18.6 µM -2.18573922992766 0.0205320117273718 no 3249 0.0144173445157172 4730 688866
SGTC_566 0958-0068 16.5 µM -2.19620677367386 0.0200517417113456 no 3250 0.0140385733847504 4660 6815365
SGTC_1173 0443-0020 122 µM -2.19908730027667 0.0199212620300861 no 3251 0.013935857688021 4715 5331295
SGTC_2233 sulbentine 40.3845 µM -2.20252048840054 0.019766690039268 no 3252 0.0138142817521212 4729 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2883 9059145 45.46 µM -2.20734617255534 0.0195511458773503 no 3253 0.0136449419236371 4730 16476510
SGTC_2628 lathosterol 100 µM -2.21364037411513 0.0192730113956114 no 3254 0.0134267638180395 4717 6710616
SGTC_1929 genistein trimethyl ether 50.5 µM -2.21648072127982 0.019148604671019 no 3255 0.0133292983901135 4700 136420
SGTC_1044 1222-0021 1.78 µM -2.22411698597107 0.0188175178101378 no 3256 0.0130702871748599 4671 4306703
SGTC_1818 st052136 56.3 µM -2.22704753274275 0.0186917572829321 no 3257 0.0129720485977067 4478 674169
SGTC_1699 st031318 29.054 µM -2.22705545439602 0.0186914183075343 no 3258 0.0129717839134851 4755 5340658
SGTC_1512 0259-0544 12.2 µM -2.23600074955513 0.0183119642059161 no 3259 0.0126758610295864 4706 18476
SGTC_1237 0330-0133 46.1 µM -2.24238208851053 0.0180452996992373 no 3260 0.0124683442101719 4703 X1237 YHR072W ERG7
SGTC_2033 5192550 145 µM -2.24369915915996 0.0179906758256367 no 3261 0.0124258821284633 4726 182073
SGTC_2429 5902844 64.44 µM -2.24648349332059 0.0178756629470824 no 3262 0.0123365278358102 4725 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_3294 9122953 26.2835 µM -2.25243160178429 0.0176320630519302 no 3263 0.0121475052772128 4714 16459826
SGTC_2297 7971671 152.32 µM -2.25420725337144 0.0175598940922761 no 3264 0.0120915663501745 4703 909016
SGTC_168 3970-0862 530.542 µM -2.26038158120069 0.0173109064345355 no 3265 0.0118987893211819 4681 3135186
SGTC_2622 2-methoxyxanthone 59.94 µM -2.26619699465606 0.0170791564697935 no 3266 0.0117196622875201 4714 71034 A hepatoprotective.
SGTC_2759 disulfiram 3.38 µM -2.2665280276886 0.0170660446266891 no 3267 0.0117095365531955 4664 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1701 st028638 40.4 µM -2.27824297786475 0.0166075368661924 no 3268 0.011356052477261 4740 3490878
SGTC_125 0133-0007 11.75 µM -2.27825775270826 0.0166069653207243 no 3269 0.011355612584772 4778 26541
SGTC_174 3553-0389 74.3 µM -2.28346490100897 0.0164065791520841 no 3270 0.0112014990372898 4738 738071
SGTC_1499 4480-0877 67.3 µM -2.28912008302399 0.0161913000565681 no 3271 0.0110361881288046 4757 2861909
SGTC_2765 myclobutanil 7.74 µM -2.30281215083225 0.0156800759946961 no 3272 0.0106447072868899 4722 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1629 st005085 44.9 µM -2.30637037059766 0.0155495112646704 no 3273 0.0105449730582418 4706 24207091
SGTC_3055 9094636 49.47 µM -2.31140173083881 0.0153664844727088 no 3274 0.010405337721115 4738 25236176
SGTC_1266 0828-0227 32.9 µM -2.3156385281272 0.0152137993750473 no 3275 0.0102890066795166 4709 3913820
SGTC_2526 patulin 37.61 µM -2.31908476046016 0.0150905674670643 no 3276 0.010195220456409 4719 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1800 st050079 29.0735 µM -2.3303783269634 0.0146927202130803 no 3277 0.00989308211265884 4620 3645560
SGTC_1297 1068-0111 14.1 µM -2.33761356754084 0.0144426088870641 no 3278 0.00970365174249923 4756 767057
SGTC_394 menadione 8.33 µM -2.33771745862589 0.0144390443891294 no 3279 0.0097009549461412 4729 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_214 4373-3496 70 µM -2.34441328832902 0.0142109026105213 no 3280 0.00952852061504952 4764 3779166
SGTC_3152 9099253 49.47 µM -2.34541481058991 0.0141770469139475 no 3281 0.00950296065446214 4606 25236131
SGTC_690 glyoxal 20.3 µM -2.34647505341597 0.0141412819575314 no 3282 0.00947596742408514 4591 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_980 1473-0395 201 µM -2.37767708442819 0.0131230070026736 no 3283 0.00871103766976998 4724 768876
SGTC_1829 berberine 14.4 µM -2.40097836458463 0.0124044951774572 no 3284 0.0081756516158135 4700 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_210 3551-0445 56.827 µM -2.41807272296335 0.0118992819706316 no 3285 0.00780147905820183 4716 2865180 YOR207C RET1
SGTC_158 k038-0087 26.446 µM -2.41907421754782 0.0118702450033924 no 3286 0.0077800325552052 4691 X158
SGTC_667 1498-1044 59 µM -2.43848781340736 0.011319397042336 no 3287 0.00737442799213661 4757 6739982
SGTC_335 4077-0256 27.6 µM -2.44877472936613 0.011036619715064 no 3288 0.00716715337594012 4669 3121989
SGTC_123 0083-0120 66.675 µM -2.45425988566201 0.0108883651039399 no 3289 0.00705874557397358 4740 16001701
SGTC_894 0960-0238 55.9 µM -2.46700956686457 0.0105504422544297 no 3290 0.00681233586827312 4756 6741907 YDL195W SEC31
SGTC_413 propylparaben 100 µM -2.47918162316986 0.0102363917714283 no 3291 0.00658421165494656 4753 7175 A pharmaceutical preservative.
SGTC_1646 st011709 75.6 µM -2.48339164352218 0.0101296831333267 no 3292 0.00650689600768293 4748 5757843
SGTC_3191 9110352 49.47 µM -2.48568690607839 0.0100719164110396 no 3293 0.00646508342071585 4733 17122424
SGTC_5 0352-0601 109.883 µM -2.52452681821224 0.00913709239606232 no 3294 0.00579270824517704 4692 762456
SGTC_1735 st034310 56.75 µM -2.53370680544291 0.00892757285413202 no 3295 0.00564315603197721 4750 871153
SGTC_555 4296-0685 37 µM -2.55523363263162 0.00845268787992509 no 3296 0.00530582726388807 4778 2908540 YHR072W ERG7
SGTC_2885 9057732 51.95 µM -2.56974300645196 0.00814525303469153 no 3297 0.00508869921026608 4767 6471414
SGTC_346 4513-0042 7.16 µM -2.57427095292647 0.00805134468016726 no 3298 0.00502257862591266 4742 2827372
SGTC_2047 4141938 200 µM -2.58481986708066 0.00783624584898928 no 3299 0.00487149422440123 4780 3807862
SGTC_1501 4491-0275 38.4 µM -2.60195107958247 0.00749769193067682 no 3300 0.00463475369138904 4787 5104718
SGTC_1475 4092-1048 11.7 µM -2.60587443526988 0.00742199490410518 no 3301 0.00458200246826602 4769 2881759
SGTC_2889 9059656 51.95 µM -2.6236668091526 0.00708709808336877 no 3302 0.00434944183848882 4777 3949838
SGTC_2086 5274770 176.623 µM -2.64028531748206 0.00678641308553766 no 3303 0.00414181280680415 4782 689278
SGTC_1638 st008370 60.6 µM -2.67658995401445 0.00616844695568225 no 3304 0.00371877987388218 4745 24207134
SGTC_71 0417-1750 47.813 µM -2.67824665254257 0.00614147628491665 no 3305 0.00370043482267081 4743 6811472
SGTC_1733 st037357 54.9 µM -2.68321366172908 0.00606123963286371 no 3306 0.00364591938601128 4735 1272339 YGL099W LSG1
SGTC_2437 5741531 144.16 µM -2.69191836356046 0.0059228631421872 no 3307 0.0035521166357033 4764 2262990
SGTC_1524 corynanthine 62.1 µM -2.69658199032591 0.00584988522340274 no 3308 0.00350275745252929 4784 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1718 roemerine 11.9335 µM -2.70143028437333 0.00577486431526013 no 3309 0.00345209765050819 4521 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2131 toluylene red 5.2905 µM -2.7293179232373 0.00535969179262188 no 3310 0.00317327427143482 4749 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_392 N-ethylmaleimide 8.33 µM -2.7349704152976 0.00527885085261137 no 3311 0.00311929414274345 4771 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2377 9073351 62.6 µM -2.73653417525707 0.00525667861038649 no 3312 0.00310450726353413 4769 7337946 YHR072W ERG7
SGTC_2190 6049624 200 µM -2.7571697954745 0.0049717542265017 no 3313 0.0029152033606351 4761 2265554
SGTC_2328 6201408 200 µM -2.78917901142255 0.00455696352997187 no 3314 0.00264209242696019 4749 2890418
SGTC_2408 sulbentine 18.36 µM -2.80425915213982 0.00437247697837929 no 3315 0.00252161754714733 4702 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1546 5-methoxyflavanone 78.7 µM -2.80631176606089 0.00434788882974292 no 3316 0.00250560906425364 4794 147795
SGTC_1134 3477-0009 42.5 µM -2.8184261628888 0.00420527184457559 no 3317 0.00241298546456495 4759 3973534
SGTC_3189 9110682 49.47 µM -2.84422193762035 0.00391544609857722 no 3318 0.0022260012803424 4778 17122418
SGTC_1072 oxiconazole 14.9 nM -2.87138524737154 0.00362972034560709 no 3319 0.0020433856546963 4767 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2371 9071574 200 µM -2.8905573026964 0.0034394671919318 no 3320 0.00192279707717229 4792 45596039
SGTC_310 1273-0058 1.06 µM -2.89093447505996 0.00343581591707168 no 3321 0.00192049097692312 4486 2734232
SGTC_953 1188-0045 9.7 µM -2.91398611665631 0.0032191641021673 no 3322 0.00178422887975966 4762 6144426
SGTC_172 1112-0046 2.638 µM -2.95816890364967 0.00283795870295393 no 3323 0.00154736250728565 4776 2802135 YIL048W NEO1
SGTC_393 acivicin 6.25 µM -2.98457688433094 0.00263004411674612 no 3324 0.00141985413266849 4742 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_3254 9136651 49.47 µM -2.99355508204254 0.00256255559790127 no 3325 0.00137873864699536 4775 16454030
SGTC_2569 tetrandrine 100 µM -2.99481293971672 0.00255322641561683 no 3326 0.00137306598587707 4779 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_57 miconazole 162.5 nM -3.03592640775445 0.00226470086121978 no 3327 0.001198989425782 4711 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1906 st060206 94.7 µM -3.11328467386531 0.00180056529706963 no 3328 0.000925087314832092 4793 5133468
SGTC_761 k216-0224 480 µM -3.12443213140329 0.00174133468546818 no 3329 0.000890743068162053 4797 1340404
SGTC_2511 berberine 10.47 µM -3.17888819313834 0.00147668668475961 no 3330 0.000739205529332303 4785 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1370 2001-0092 44.6 µM -3.19794779143471 0.00139310245636425 no 3331 0.000692046681085691 4753 790957
SGTC_897 1000-0139 31.4 µM -3.20138133338681 0.00137851252325579 no 3332 0.000683851986074462 4789 6151020
SGTC_3052 9092717 49.47 µM -3.26409979810106 0.00113541971788836 no 3333 0.00054906238961145 4791 25237534
SGTC_22 0964-0034 14.468 µM -3.28013817216974 0.0010799092233953 no 3334 0.000518781291843029 4803 138402
SGTC_1552 6-methylflavone 10.6 µM -3.29456352491469 0.00103211850362389 no 3335 0.000492873306468489 4800 689013
SGTC_314 1671-0008 2.74 µM -3.3392123480631 0.000896226893160841 yes 3336 0.000420081568724554 4751 3913060
SGTC_2087 5276107 200 µM -3.41481739398093 0.000703044190781458 yes 3337 0.000319123923155273 4802 144405
SGTC_115 0527-0192 112.043 µM -3.4169022411634 0.000698306990622462 yes 3338 0.000316690095730905 4779 4233931
SGTC_299 1273-0059 1.44 µM -3.44041118580372 0.000646889387066499 yes 3339 0.000290415515257171 4686 2848077
SGTC_1905 st060207 84.5 µM -3.47040037439974 0.000586370160944816 yes 3340 0.000259841544294058 4799 1948547
SGTC_1023 4482-3888 16 µM -3.53875686353811 0.000467454770816677 yes 3341 0.000201007973344502 4790 3303168
SGTC_327 1273-0057 3.96 µM -3.58938631482089 0.000394238097939681 yes 3342 0.000165728670314019 4793 3108138
SGTC_1998 st075797 76.8 µM -3.60884908363796 0.000369041574959964 yes 3343 0.000153779227561509 4806 24208315
SGTC_2778 tioconazole 65.09 nM -3.69897147154772 0.000270700931480381 yes 3344 0.00010823746437079 4767 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3018 9082602 49.47 µM -3.75254358542364 0.000224443770832345 yes 3345 8.75246926674933e-05 4755 17332089
SGTC_256 clotrimazole 625 nM -3.84122258335426 0.000163730368653089 yes 3346 6.12115202204829e-05 4796 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_377 3970-0964 33.1 µM -3.86677156373953 0.000149327676287445 yes 3347 5.51428216814411e-05 4805 16481235
SGTC_689 0833-0039 98 µM -3.97998209830962 9.86543194683125e-05 yes 3348 3.44602290138418e-05 4796 5374726
SGTC_1786 berberine 21.6 µM -4.19819556581162 4.30591253431096e-05 yes 3349 1.34525118915334e-05 4786 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_245 methotrexate 289.6 µM -4.40509342445384 1.89127449799173e-05 yes 3350 5.2869148593931e-06 4781 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1558 st069300 45.6 µM -4.56511303682474 9.76633460879674e-06 yes 3351 2.4961263439349e-06 4806 24208000
SGTC_252 miconazole 1.30953 nM -4.95407068802698 1.79106200399839e-06 yes 3352 3.63383922542835e-07 4804 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2100 5377183 190 µM -5.16488431753302 6.77198096501161e-07 yes 3353 1.20293835484787e-07 4809 2844202
SGTC_1547 harmine 94.2 µM -5.50586034751568 1.29701561224083e-07 yes 3354 1.836848373046e-08 4804 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_3196 9111891 49.47 µM -5.76485788004206 3.46022990542995e-08 yes 3355 4.08633402011383e-09 4809 18891510
SGTC_217 ketoconazole 989 nM -8.93721946625431 3.06214510918103e-17 yes 3356 1.99542625516112e-19 4793 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4