SGTCid condition conc unit RRP5|YMR229C.score RRP5|YMR229C.strain.pval RRP5|YMR229C.strain.significant RRP5|YMR229C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_359 0081-0058 15.9 µM 6.30190247333849 2.57796332421041e-13 yes 1 1.47007079279249e-10 3 3494159
SGTC_309 k408-0051 1.48 µM 6.12035599910394 1.15296933162355e-12 yes 2 4.66832629168613e-10 9 3640463
SGTC_902 1120-0002 2.07 µM 4.92727948429981 7.68258170868123e-09 yes 3 4.16912222950331e-07 13 3280475
SGTC_844 0330-0132 15.3 µM 4.33562268550541 3.10769125942346e-07 yes 4 7.26740394926218e-06 4 2828079
SGTC_1044 1222-0021 1.78 µM 3.97864466853491 2.34357338663223e-06 yes 5 3.46546168506454e-05 35 4306703
SGTC_1453 4237-0541 195 µM 3.97828197196621 2.3481992724713e-06 yes 6 3.4707511290021e-05 15 739892
SGTC_1451 4152-0210 104 µM 3.9668817157969 2.4981398156075e-06 yes 7 3.64095544051062e-05 2 659563
SGTC_1292 0kpi-0043 232 µM 3.49944002499404 2.75100388926822e-05 yes 8 0.000233118238705829 5 3333905
SGTC_2233 sulbentine 40.3845 µM 3.49901967719579 2.75660943149385e-05 yes 9 0.000233486059009201 43 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1224 0823-0416 294 µM 3.44207177331757 3.62465796364935e-05 yes 10 0.000288638530457957 4 3598164
SGTC_545 4218-0007 221 µM 3.34495356746011 5.72821168537748e-05 yes 11 0.000411481733092508 11 2840508
SGTC_1038 k292-0204 154 µM 3.28834024932926 7.43964791726704e-05 yes 12 0.000503899803986193 11 4454212
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 3.25225971564075 8.77034237878195e-05 yes 13 0.000572456770056684 13 688798
SGTC_2013 4024628 200 µM 3.05828717347817 0.000206698175109132 yes 14 0.00111303069262705 17 5230760
SGTC_1763 st044482 94.5 µM 2.88812832184027 0.000422195107332423 yes 15 0.00193770867633542 18 88505
SGTC_362 0310-0100 9.03 µM 2.79742812013041 0.000608974803639248 yes 16 0.00257556137490554 24 790235
SGTC_2647 atorvastatin 60.16 µM 2.74474155896369 0.000749932145332767 yes 17 0.00302792838801159 12 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_790 1575-0012 79.1 µM 2.73218136516566 0.000787703758732392 yes 18 0.00314582481090954 20 378741 YLR208W SEC13
SGTC_846 0335-0850 148 µM 2.72170103805387 0.000820552901890064 yes 19 0.00324734340085856 19 6819598
SGTC_1895 st058434 18.3 µM 2.7033600295005 0.000881089524851478 yes 20 0.00343211756870674 25 5393175
SGTC_2029 5175081 200 µM 2.69077046522996 0.000924990779083843 yes 21 0.0035643612040918 25 1380876
SGTC_2346 9031566 143.75 µM 2.6740507005767 0.000986402572493466 yes 22 0.00374705603507142 28 4771086
SGTC_70 0141-0289 43.283 µM 2.6675680091514 0.00101120418865597 no 23 0.00382012121714478 44 352408
SGTC_627 1391-0720 175 µM 2.63167281669088 0.00115919409149035 no 24 0.00424828214474655 25 997839
SGTC_41 0478-0632 82.643 µM 2.62878726490516 0.00117191278125707 no 25 0.00428449738048696 42 3750424
SGTC_3354 9151612 71.43 µM 2.60285588103519 0.00129207800450084 no 26 0.00462254039462525 11 27261949
SGTC_2928 9011484 9.79 µM 2.56627251906413 0.00148080851176441 no 27 0.00513990141848129 59 2994751
SGTC_2518 prenyletin 46.28 µM 2.553163609432 0.00155433869983168 no 28 0.00533746695084506 7 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2780 5215298 71.43 µM 2.54602192816618 0.0015957840954271 no 29 0.00544791718077543 42 2834131
SGTC_1291 0993-0025 5.79 µM 2.51135554705022 0.00181163744581028 no 30 0.00601342483425248 18 4353356
SGTC_2156 5649887 115 µM 2.48904763013134 0.00196424443645911 no 31 0.00640429023739329 41 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1284 0929-0043 16 µM 2.45950479606623 0.00218430313077362 no 32 0.00695644193340129 29 1239883
SGTC_353 1988-1175 58.3 µM 2.4318404142311 0.00241038726765915 no 33 0.00751116225689855 45 2788357
SGTC_1125 tnp00248 1.32998 µM 2.4279646907995 0.0024436985694179 no 34 0.00759191072131637 43 24207736
SGTC_1606 st000094 49.2 µM 2.40936877743377 0.00260939311039565 no 35 0.00799007078100433 33 1242210
SGTC_39 0986-0283 58.349 µM 2.36729825539968 0.00302229493888472 no 36 0.00895924308977854 34 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1465 k213-0056 144 µM 2.36568999150499 0.00303918747199096 no 37 0.00899825337341264 46 24048857 YMR208W ERG12
SGTC_2277 7947813 106.88 µM 2.35753026393001 0.00312621126786285 no 38 0.00919847783179712 39 1246798
SGTC_1648 st011736 69.8 µM 2.33747872654067 0.00334966647246071 no 39 0.00970715291104593 28 2855514
SGTC_1034 k072-0165 12.7 µM 2.32911188728209 0.00344707815888733 no 40 0.00992656955364608 32 5835461
SGTC_2831 7999036 19.48 µM 2.26865406677633 0.00422996204048739 no 41 0.0116446854700828 43 2988270
SGTC_2519 cryptotanshinone 88.04 µM 2.2653288890655 0.00427730767623869 no 42 0.0117462522580679 61 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1637 st007924 17.4 µM 2.25174777346822 0.00447563959808576 no 43 0.0121691078939326 31 683336
SGTC_2331 7980721 200 µM 2.2433626377521 0.00460215472990539 no 44 0.0124367195793026 51 2981221
SGTC_254 nsc-64875 3.808 µM 2.21755830010169 0.00501175221559443 no 45 0.0132924818990074 23 56993
SGTC_1421 4029-0249 71.4 µM 2.19018199206211 0.00548150390243778 no 46 0.0142555203533642 34 2894095
SGTC_1903 st060211 78.3 µM 2.1695084866526 0.0058617634679486 no 47 0.0150220503783248 42 688960
SGTC_174 3553-0389 74.3 µM 2.15675102087052 0.00610792944635543 no 48 0.0155125346344773 42 738071
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 2.15070075653075 0.006227844213226 no 49 0.0157499133109794 66 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1138 3761-0006 1.03 µM 2.14504773586189 0.00634176495610823 no 50 0.0159745152560159 18 12061087
SGTC_1080 nisoldipine 24.4 µM 2.14188056862791 0.0064063932340918 no 51 0.0161015469397349 47 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_988 1497-1057 103 µM 2.13176077054473 0.00661681804371894 no 52 0.0165132590676747 39 3533044
SGTC_2545 solidagenone 89.61 µM 2.1156396033911 0.00696466439338047 no 53 0.0171877354444414 15 6708572 An anti ulcer agent
SGTC_569 4130-2812 160 µM 2.11309452112407 0.00702103059298414 no 54 0.0172963392685774 40 743552
SGTC_1552 6-methylflavone 10.6 µM 2.11118708181247 0.00706353842139745 no 55 0.0173781173746495 46 689013
SGTC_1310 1188-0297 994 nM 2.10336536373479 0.00724023194067767 no 56 0.017716921862921 57 1588352
SGTC_2510 benzyl isothiocyanate 8.31 µM 2.09970929492433 0.00732415144395632 no 57 0.017877210720909 72 2346 DNA damaging agent; causes G2/M arrest.
SGTC_3309 9129340 25.759 µM 2.08919094901435 0.00757038477881973 no 58 0.0183452689283888 37 17158987
SGTC_1 0258-0098 57.368 µM 2.08881810593068 0.0075792452161568 no 59 0.0183620499599085 50 6790032 YDR047W HEM12
SGTC_2563 tomatine 8.54 µM 2.08782743004047 0.0076028325394908 no 60 0.0184067021358828 59 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1086 cerivastatin 2.18 µM 2.08372976385023 0.00770108317542788 no 61 0.0185923776313175 34 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1896 st058441 89 µM 2.08195140369201 0.00774406991264714 no 62 0.0186734543959363 46 688759
SGTC_2533 agelasine 13.65 µM 2.07070329742725 0.00802088437195131 no 63 0.0191932659500166 62 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2263 7948595 193.29 µM 2.06557928662945 0.00814984383499903 no 64 0.0194341109614205 35 2971371
SGTC_1257 0669-0121 16 µM 2.05821727856676 0.0083383169045933 no 65 0.0197846403514459 39 4307855
SGTC_3327 9140648 26.9345 µM 2.05550650195785 0.00840867284558351 no 66 0.0199150541528045 81 8029710
SGTC_1132 3456-3614 2.5 µM 2.05240475978828 0.00848981476879569 no 67 0.0200651711712727 48 3125502
SGTC_2644 guaiazulene 100 µM 2.04686279122839 0.00863650504464261 no 68 0.020335779179241 26 3515 A coloring agent.
SGTC_891 0929-0073 133 µM 2.03718551879106 0.00889798781830111 no 69 0.0208157272338368 49 5603632
SGTC_2788 5282734 71.43 µM 2.02949334897489 0.00911075534784833 no 70 0.0212040328698512 61 743706
SGTC_372 0155-0182 15.9 µM 2.02791753566214 0.00915488844583759 no 71 0.0212843325558295 38 771486
SGTC_1624 st003710 6.25 µM 2.02270989673082 0.0093020704308167 no 72 0.0215515329720091 40 24207033
SGTC_1311 1190-0148 100 µM 2.00264901215716 0.00988856749043014 no 73 0.0226074875888585 58 1961333
SGTC_2525 harmine 47.85 µM 2.00053461047542 0.00995222581982308 no 74 0.0227212832388484 39 5280953 A monoamine oxidase inhibitor
SGTC_1737 st035557 69.7 µM 1.99979760909556 0.00997449866544518 no 75 0.0227610614405296 57 5716916
SGTC_520 3584-0023 682 µM 1.99110374969278 0.0102405368944751 no 76 0.0232347411572148 62 1340790
SGTC_2124 5246320 200 µM 1.99050442245524 0.0102591026544232 no 77 0.0232676986558729 77 579342
SGTC_694 1315-0438 43.2 µM 1.97985502677127 0.0105939250340836 no 78 0.0238599105620802 40 6793154
SGTC_953 1188-0045 9.7 µM 1.97153215058906 0.0108621887195805 no 79 0.0243315196493485 60 6144426
SGTC_116 0155-0182 31.788 µM 1.96258641298807 0.0111571024684217 no 80 0.02484712537579 47 771486
SGTC_998 3996-0085 177 µM 1.95990954569101 0.0112466933103912 no 81 0.0250031818520768 50 715391
SGTC_762 1165-0429 115 µM 1.9247077479036 0.0124843061358701 no 82 0.0271329653281418 56 5967793
SGTC_2335 9018011 154.17 µM 1.90011978035522 0.0134172039355931 no 83 0.0287087012246926 68 6458208
SGTC_1398 3558-0053 112 µM 1.89489992334048 0.0136228204207322 no 84 0.0290528306726916 32 4532369
SGTC_2092 5303694 80.6725 µM 1.89098386218088 0.0137788587454469 no 85 0.0293132492460747 62 1963699
SGTC_406 estrone 100 µM 1.88864417546438 0.0138728190319245 no 86 0.0294697617427861 47 5870 A steroid.
SGTC_2462 5162487 171.77 µM 1.88358613187493 0.0140778367098174 no 87 0.0298104895883088 61 2259986
SGTC_352 k048-0007 5.11 µM 1.87312876425158 0.014509997594693 no 88 0.0305253030957838 93 6811911
SGTC_287 k060-0039 29.6 µM 1.87051031773824 0.0146199782898874 no 89 0.0307064927818976 68 5861974
SGTC_3209 9113616 49.47 µM 1.8541196745089 0.0153248505645591 no 90 0.0318610202710318 74 16649353
SGTC_1755 st041960 45.185 µM 1.8539341855191 0.0153329915839999 no 91 0.0318742881907173 75 2257073
SGTC_2447 5741742 33.78 µM 1.84924005207294 0.0155402545042359 no 92 0.0322115788577952 71 1776504
SGTC_845 0330-0138 4.51 µM 1.8450769415196 0.0157260782292488 no 93 0.0325131734650362 64 9039800
SGTC_1057 3448-5381 134 µM 1.84342019616755 0.0158005568186434 no 94 0.0326338417911132 75 5497911
SGTC_2555 cholic acid 100 µM 1.8430614212015 0.0158167252500582 no 95 0.0326600216009476 41 6708657 Influences liver metabolism.
SGTC_2430 5571206 200 µM 1.8398426469395 0.0159624171857753 no 96 0.0328956711180465 83 1731771
SGTC_1220 1838-0075 193 µM 1.83863225265365 0.0160175003506748 no 97 0.0329846470455327 55 5529645
SGTC_2941 9056145 11.23 µM 1.83820217487358 0.0160371117140835 no 98 0.0330163097234799 60 2119517
SGTC_875 0709-0210 25.7 µM 1.83215715060662 0.0163149471897088 no 99 0.0334640053750041 68 6251364
SGTC_1333 1482-0047 286 µM 1.83183701551504 0.0163297751627399 no 100 0.0334878533161517 66 3811116
SGTC_2096 5468907 200 µM 1.82630326234916 0.0165879165691791 no 101 0.0339022970534598 57 759785
SGTC_2004 4023728 41.89 µM 1.82242465044262 0.0167709228957105 no 102 0.0341952885586519 96 360084 YDR527W RBA50
SGTC_450 aminopyrene 156 nM 1.81776346466213 0.0169931361560872 no 103 0.0345501464933316 62 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1306 1185-0270 9.02 µM 1.81248733589857 0.017247698079328 no 104 0.0349554644908523 59 1548076
SGTC_2491 paeonol 100 µM 1.81038198564781 0.0173501823195338 no 105 0.0351182854594767 46 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1741 st038134 10.228 µM 1.80462494520249 0.0176330828411943 no 106 0.0355666959197263 64 1272587
SGTC_3332 9141069 11.198 µM 1.79644068316882 0.0180420272415826 no 107 0.036212229248355 49 17332883
SGTC_639 0833-0042 114 µM 1.77970594876217 0.018903430854635 no 108 0.0375620482051329 80 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2211 7117706 200 µM 1.77675937725483 0.0190586694717117 no 109 0.037803919106798 50 822771
SGTC_316 k060-0003 58.6 µM 1.76914547719517 0.0194648315797707 no 110 0.038434800135305 70 6152314
SGTC_1561 5-methoxyflavone 52.9 µM 1.74147029009879 0.0210036442408973 no 111 0.040800588311448 55 94525
SGTC_1270 0831-1170 17.3 µM 1.74136700127148 0.0210095748296272 no 112 0.0408096342984171 73 6764716
SGTC_3013 9080133 71.4286 µM 1.73895190069831 0.0211486483947449 no 113 0.0410216119204593 67 17050193
SGTC_1654 st012436 41.8 µM 1.73602539584122 0.0213182140433584 no 114 0.0412796721212802 43 4323132
SGTC_382 3229-0966 23.2 µM 1.73325863746662 0.02147957958935 no 115 0.0415248544902085 70 5722370
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.7138585107033 0.0226403000507139 no 116 0.0432773572076068 76 551469
SGTC_1525 8-methoxypsoralen 92.5 µM 1.71267663498654 0.0227126890982389 no 117 0.0433860229663155 96 4114 Related to psoralen; DNA damaging agent.
SGTC_1630 st005209 31.3 µM 1.70961738065968 0.022900972743152 no 118 0.0436683247514212 66 3367314
SGTC_603 3794-0023 45.9 µM 1.7093128556793 0.022919786668821 no 119 0.0436965066280963 66 3802260
SGTC_2834 9001755 58.44 µM 1.69481694590726 0.0238305428453155 no 120 0.0450550758966253 73 2989575
SGTC_2199 6590217 200 µM 1.69352913333445 0.0239129055540894 no 121 0.0451773971526619 71 703109
SGTC_542 3381-0244 89.3 µM 1.68920327830326 0.0241913214006753 no 122 0.0455902404895466 76 1112843
SGTC_1098 clofazimine 15.1 µM 1.68781814851136 0.0242810430380989 no 123 0.0457230713412255 103 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1360 1598-0022 39.8 µM 1.68327983211204 0.0245769719685847 no 124 0.0461604663655035 94 761525
SGTC_1793 st048256 72.231 µM 1.68276087084113 0.0246110037895191 no 125 0.0462106963421825 67 672022
SGTC_1179 1021-1431 9.29 µM 1.68098324929787 0.024727874369324 no 126 0.0463830841150133 85 2840958
SGTC_1705 st027868 56.3335 µM 1.66893614571909 0.0255322465287727 no 127 0.0475650176126434 66 292948
SGTC_2066 5222451 176 µM 1.66782706441816 0.0256073877776218 no 128 0.0476750308021192 119 2281147
SGTC_1412 3909-8563 178 µM 1.66234192473592 0.0259817382024328 no 129 0.0482221180763541 71 23767530
SGTC_383 2324-0395 7.37 µM 1.66168264406087 0.0260270395158997 no 130 0.048288211446161 59 3146421
SGTC_2471 5466956 24.79 µM 1.66033334818482 0.0261199600056517 no 131 0.0484237052594244 107 724419
SGTC_3308 9128332 17.569 µM 1.64938761793683 0.0268840485459849 no 132 0.0495341248850905 86 17332805 YDL196W YDL196W
SGTC_2524 avocatin b 10.57 µM 1.64414537564127 0.0272565506829051 no 133 0.050073088511001 45 6710748
SGTC_2183 6420625 130.508 µM 1.6316055722112 0.0281650964896723 no 134 0.0513813018157984 100 2897619
SGTC_2305 7443522 69.23 µM 1.63098294824371 0.0282108567162987 no 135 0.0514469587858493 86 5415886
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.62682361691197 0.0285181401671517 no 136 0.0518872821208638 66 17037758
SGTC_2272 7805186 180 µM 1.62462095410615 0.0286819931662667 no 137 0.0521216747467919 81 2956062 YPR165W RHO1
SGTC_127 0180-0333 59.125 µM 1.61913703179613 0.0290933379070361 no 138 0.0527088912899884 63 771601
SGTC_946 3434-1334 87.4 µM 1.61483812961446 0.0294192120135742 no 139 0.0531728767680843 94 4047976
SGTC_664 1222-0054 14.9 µM 1.60676166905193 0.0300396359447568 no 140 0.0540533298576042 100 6813991
SGTC_2551 apiole 73.87 µM 1.60376531013388 0.0302725547335983 no 141 0.0543828968859663 67 10659 A possible DNA adduct former.
SGTC_3340 9146634 11.102 µM 1.60202514218894 0.0304085105382429 no 142 0.0545750249249358 64 4907387
SGTC_2853 9015042 58.44 µM 1.59878164044023 0.0306632689972408 no 143 0.054934564931728 64 6457456
SGTC_141 0443-0274 32.331 µM 1.59758239506639 0.0307579092850654 no 144 0.0550679735134052 74 1627241
SGTC_2884 9058502 51.95 µM 1.59581010603473 0.0308982148702751 no 145 0.0552655981466271 73 6471554
SGTC_2336 9001819 198.65 µM 1.58933364473109 0.0314154444543778 no 146 0.0559925433548024 135 2989602
SGTC_1521 st012942 49.4 µM 1.58516336848953 0.0317522686743471 no 147 0.0564646104916144 83 24207259
SGTC_273 hydroxyurea 18.1 mM 1.5822917513108 0.0319859332806913 no 148 0.0567914914686289 109 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_76 0433-0009 400.328 µM 1.58186480690167 0.0320207948654823 no 149 0.0568402182816011 82 2841569
SGTC_1666 st014829 29 µM 1.5801457488569 0.0321614799227392 no 150 0.0570367462155098 78 3858230
SGTC_133 0724-0033 378.92 µM 1.57968779591804 0.0321990440344626 no 151 0.0570891909218118 97 280309
SGTC_911 3456-4043 236 µM 1.57892010324534 0.0322620961374219 no 152 0.0571771921268687 84 914281
SGTC_2691 st077356 60.2 µM 1.57588738834854 0.0325121761424862 no 153 0.0575258789803154 100 2839272
SGTC_3132 9126706 49.47 µM 1.56425766209081 0.0334860386288191 no 154 0.0588785352748273 104 850858
SGTC_2341 7987486 176.74 µM 1.56386602494639 0.0335192474598731 no 155 0.0589245173895266 82 1258686
SGTC_1569 carminic acid 40.6 µM 1.56266016517205 0.0336216685008036 no 156 0.0590662743293017 75 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2139 5578692 56.4705 µM 1.56063618433504 0.0337941564545168 no 157 0.0593048080683879 102 650991 YMR113W FOL3
SGTC_2689 tacrolimus 100 µM 1.5594621968782 0.0338945393417222 no 158 0.059443512617748 87 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.55840761845515 0.0339849210453672 no 159 0.0595683258997971 87 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1312 1218-2183 165 µM 1.55734746853678 0.0340759799357612 no 160 0.0596940055138267 87 6744073
SGTC_161 4065-0411 162.148 µM 1.5560342021178 0.0341890577096057 no 161 0.0598499797986813 93 1906281 YLR208W SEC13
SGTC_2520 obtusaquinone 4.71 µM 1.54030364641524 0.0355676544432151 no 162 0.0617431776864948 104 5967872
SGTC_692 k241-0027 77.8 µM 1.53917406349426 0.0356683779975157 no 163 0.0618809038533996 87 3600480
SGTC_2934 9036370 36.88 µM 1.53840262021773 0.0357373009291087 no 164 0.061975100997686 81 6462800
SGTC_1562 morin hydrate 59.1 µM 1.53558968130553 0.0359895419927891 no 165 0.062319523264444 89 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2309 7664088 163.95 µM 1.5331577522595 0.0362087909061364 no 166 0.0626184954417776 95 704922
SGTC_222 nsc-310342 10.666 µM 1.5322824980045 0.0362879659762296 no 167 0.0627263690707771 69 432556
SGTC_822 1487-0950 154 µM 1.53036630320728 0.0364617988324211 no 168 0.0629630424596557 73 1958375
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.52657309837141 0.0368079194016646 no 169 0.0634336003533614 62 6708630 An antioxidant.
SGTC_1708 st033234 31.827 µM 1.52514317325888 0.0369390918934692 no 170 0.0636116954053432 97 674664
SGTC_451 chloral hydrate 100 µM 1.52238958623949 0.0371927654595932 no 171 0.0639557463033589 124 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1718 roemerine 11.9335 µM 1.52033213452418 0.0373832354215964 no 172 0.0642137607890738 109 235224 An aporphine alkaloid with mutagenic activity.
SGTC_321 4534-3890 65.3 µM 1.51236335361104 0.0381284831009874 no 173 0.0652207261207329 99 699746
SGTC_930 2810-3379 265 µM 1.51021247998774 0.0383316983662432 no 174 0.0654946076137446 101 1015764
SGTC_29 0299-0004 12.984 µM 1.5077903027294 0.0385616027048023 no 175 0.0658041024127947 68 16871 A napthoquinone isolated from Swertia calycina.
SGTC_774 k060-0086 136 µM 1.50352057476557 0.0389696054343993 no 176 0.0663524276857183 89 5911235
SGTC_797 k781-0471 270 µM 1.50147920772399 0.0391659108509275 no 177 0.0666158302973598 102 23738129
SGTC_1540 guanosine 70.6 µM 1.49935209274367 0.0393713176559758 no 178 0.0668911574432933 77 6802 Guanosine is a purine nucleoside
SGTC_630 4356-0227 183 µM 1.49498724497275 0.0397955578688953 no 179 0.0674588855032559 132 779312
SGTC_1315 1237-0019 3.69 µM 1.49302662956781 0.0399873251839306 no 180 0.0677151082024072 88 825140
SGTC_775 4577-0580 57.3 µM 1.49216842541841 0.0400715018920069 no 181 0.0678274987482813 97 2006902
SGTC_1736 st036774 51 µM 1.48411391132082 0.0408685630823843 no 182 0.0688893516187119 98 1272247
SGTC_2452 5863136 48.41 µM 1.48215476721656 0.0410643689444151 no 183 0.0691495595116798 88 2184096
SGTC_1830 st055982 50.3 µM 1.47864565339915 0.0414169871845179 no 184 0.0696175221676236 93 455313 An antimicrobial agent.
SGTC_279 1273-0055 2.93 µM 1.47478034532386 0.0418082340380348 no 185 0.0701358035103023 107 2847562
SGTC_1010 4112-3296 15.2 µM 1.47206609296299 0.0420847555595512 no 186 0.0705015153338134 73 704384
SGTC_228 caffeine 993.056 µM 1.47078492614169 0.0422157910502055 no 187 0.0706746451251603 54 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_908 3448-7491 47.7 µM 1.46720546792226 0.0425836421253949 no 188 0.0711600849683382 96 1203031
SGTC_2459 5811157 9.22 µM 1.46321348210806 0.0429969400309806 no 189 0.0717044864047637 94 2870684 YBR192W RIM2
SGTC_73 0327-0325 16.231 µM 1.46197968634301 0.0431253308919757 no 190 0.0718733882652876 57 53298
SGTC_2344 7990960 76.95 µM 1.45440581516152 0.0439202805947819 no 191 0.0729169143359001 131 140813
SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.45395833217632 0.0439676155232992 no 192 0.0729789293947047 109 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1799 st045822 46.1415 µM 1.45230344597358 0.0441430275726769 no 193 0.0732086248740979 113 3674992
SGTC_986 1493-0483 84 µM 1.44870264707792 0.0445266488869102 no 194 0.0737103204606637 102 40079
SGTC_525 k781-2675 26.7 µM 1.4466491324888 0.04474662566405 no 195 0.073997608966106 132 3651118 YDL195W SEC31
SGTC_2797 7859098 81.82 µM 1.44582536782113 0.0448351146392035 no 196 0.0741130945026543 112 972681
SGTC_1361 1608-0041 5.61 µM 1.44576598797813 0.0448414986747508 no 197 0.0741214244215624 109 X1361
SGTC_2550 chrysin dimethyl ether 71.87 µM 1.44541990928044 0.0448787207930176 no 198 0.0741699872399734 63 88881 An O-methylated flavonoid and antioxidant.
SGTC_1437 4092-1038 11.6 µM 1.44294572821282 0.0451455537797544 no 199 0.0745178800708895 114 3977136
SGTC_435 c-PAF 6.7 µM 1.42772224449998 0.0468155703960908 no 200 0.0766859104472265 109 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2345 9052315 157.45 µM 1.42759915488097 0.046829272584905 no 201 0.0767036335074771 110 6469265
SGTC_1186 1319-0216 26 µM 1.42577143763811 0.0470331106353621 no 202 0.0769671640316504 113 4565136
SGTC_2670 beta-carotene 100 µM 1.42576332801068 0.0470340166527006 no 203 0.0769683348548366 56 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2799 7812892 81.82 µM 1.42407288521604 0.0472231806538962 no 204 0.0772126872843582 135 20205235
SGTC_558 k064-0027 21.3 µM 1.421187040351 0.0475475212606888 no 205 0.0776311956168691 117 5088526
SGTC_557 1315-0110 16.2 µM 1.42078255716161 0.0475931234437762 no 206 0.0776899915537152 99 6833801
SGTC_48 0382-0018 55 µM 1.41764202502727 0.0479483858937612 no 207 0.0781476520588354 75 762596
SGTC_2541 muurolladie-3-one 83.07 µM 1.41697392071572 0.0480242361570145 no 208 0.0782452762045001 151 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2478 5763493 32.33 µM 1.41287408229703 0.0484917981850234 no 209 0.0788463754443129 105 1365576 YLR208W SEC13
SGTC_1354 1498-1681 81 µM 1.41091345547201 0.0487166789678665 no 210 0.0791350670841783 111 5754243
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.40696046746512 0.0491726146985928 no 211 0.0797195557893754 82 77254
SGTC_2434 5670830 169.91 µM 1.40512518286169 0.0493854507751804 no 212 0.0799920284378536 111 1549830
SGTC_956 1185-0240 191 µM 1.40478433813383 0.0494250590461504 no 213 0.0800427088537663 99 1416193
SGTC_1115 galangin 695.678 nM 1.4026934964001 0.0496685830066378 no 214 0.080354128758322 115 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3345 9148410 3.559 µM 1.40100046492248 0.0498664739963387 no 215 0.0806069670391765 106 4903596
SGTC_618 k072-0232 33.2 µM 1.39617342785686 0.0504341391037605 no 216 0.0813311382084577 125 5872756 YGL099W LSG1
SGTC_1980 st071811 45.7 µM 1.39398233749353 0.0506935072396713 no 217 0.081661469177525 120 4974850
SGTC_1280 0880-0253 10.1 µM 1.38915415077791 0.05126878841249 no 218 0.08239294015353 111 6836607
SGTC_517 1365-0151 113 µM 1.38162970900322 0.0521756709829341 no 219 0.083542713532166 103 768657
SGTC_169 k015-0017 16.025 µM 1.37790801470658 0.0526289133724652 no 220 0.084115845059501 116 1840002
SGTC_1678 st019265 80.2 µM 1.36678130683298 0.0540026207829602 no 221 0.0858469318647886 102 5367020
SGTC_2980 9014342 25.29 µM 1.35977402767149 0.0548822075569219 no 222 0.0869507218657187 147 2996599
SGTC_1113 artemisinin 1.17947 µM 1.35478521536088 0.0555152985582779 no 223 0.0877429992008906 161 2240 An anti-malaria and mitochondrial poison.
SGTC_2693 st077581 40.7 µM 1.35274498627756 0.0557758632075322 no 224 0.0880685566735575 114 25238761
SGTC_3278 9139605 49.47 µM 1.35198436258504 0.055873251655024 no 225 0.0881901588813101 115 7958859
SGTC_1520 flindersine 88 µM 1.34753173762658 0.0564460490862064 no 226 0.0889045194466517 123 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2717 st081029 62.2815 µM 1.34364360491252 0.0569500048355498 no 227 0.0895318309207186 106 5292846
SGTC_2015 5119600 184 µM 1.3405109990615 0.0573586053371912 no 228 0.0900396354199901 135 2828786
SGTC_1255 0566-0045 221 µM 1.33711582045642 0.0578040554669871 no 229 0.090592416928446 124 2788469
SGTC_760 0568-0725 82.9 µM 1.33615323748409 0.0579308407226981 no 230 0.0907495960147889 120 3916171
SGTC_2439 5492030 7.2 µM 1.33579053615803 0.0579786700737828 no 231 0.0908088735696156 124 5722370
SGTC_2930 9013230 14.89 µM 1.33537977281561 0.0580328748253416 no 232 0.0908760407579402 132 2995857
SGTC_1222 0366-0074 1.18 µM 1.33461156014147 0.0581343558375792 no 233 0.091001756253927 132 286520
SGTC_1476 4112-3294 3.34 µM 1.33387846346968 0.0582313279890141 no 234 0.0911218453802921 120 704369
SGTC_1783 st039459 87.517 µM 1.33138388695761 0.0585622563386194 no 235 0.0915313642583692 129 729761
SGTC_1327 1436-0082 2.18 µM 1.32474769178318 0.0594497986645241 no 236 0.0926274246415635 130 15992205
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.32171930137856 0.059858311594413 no 237 0.0931308194895799 139 279621
SGTC_2076 5212012 200 µM 1.31970646719005 0.0601310458577554 no 238 0.0934665199860834 105 604802
SGTC_616 4092-0450 108 µM 1.31782372624367 0.0603870325137575 no 239 0.0937813317325951 120 787165
SGTC_966 1300-0360 30.2 µM 1.31726321656533 0.0604634066604955 no 240 0.0938752051814657 153 70588
SGTC_848 0368-0089 85.6 µM 1.30063256688984 0.0627640419085573 no 241 0.096692127054857 123 762535
SGTC_67 0335-0847 266 µM 1.30036033257178 0.0628022617007691 no 242 0.0967387493619678 143 4552207 YOR254C SEC63
SGTC_2781 5567276 71.43 µM 1.29913842701422 0.0629740321028514 no 243 0.0969482138331074 129 2853274
SGTC_987 1497-1013 404 µM 1.29273443176647 0.0638802710773598 no 244 0.0980514623958138 122 1676435
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.29250984267213 0.0639122361484622 no 245 0.0980903197734204 143 5024745
SGTC_1725 st036284 20.55 µM 1.28710938332898 0.0646846185123173 no 246 0.0990280826749243 119 707914
SGTC_208 k072-0098 12.366 µM 1.28702609020269 0.0646965877443626 no 247 0.0990425972861926 138 5948901
SGTC_663 1486-0733 13.9 µM 1.28363895397131 0.0651847782621697 no 248 0.0996341566300898 129 722445 YPR165W RHO1
SGTC_2284 7945075 39.21 µM 1.2833824918238 0.065221858440668 no 249 0.0996790523588014 127 1245402
SGTC_3068 9116768 49.47 µM 1.27972005982077 0.065753172814763 no 250 0.100321803535559 137 41904888
SGTC_3299 9121982 43.1275 µM 1.27951449359396 0.0657830937589983 no 251 0.100357969538564 118 17594604 YPL160W CDC60
SGTC_1145 3546-0597 10.2 µM 1.27737542274118 0.0660950702436908 no 252 0.100734868696093 118 875334
SGTC_767 0929-0023 86 µM 1.27730288351117 0.0661056699121188 no 253 0.100747668006947 147 1204563
SGTC_2129 girgensonine 121.053 µM 1.27493757509332 0.0664520185124775 no 254 0.101165669036325 156 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1531 st059297 52.4 µM 1.27488756841764 0.0664593560516967 no 255 0.101174519916813 129 7566702
SGTC_2122 5258151 111.688 µM 1.2686801797255 0.0673750544714557 no 256 0.102277577179086 116 2173356
SGTC_783 0848-0141 92.7 µM 1.26656250111769 0.0676896703174173 no 257 0.102655883946407 156 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1792 st045773 43.6 µM 1.26588045426784 0.0677912408161181 no 258 0.102777942565473 57 2919270
SGTC_1141 3253-0389 52.6 µM 1.26463822518751 0.0679765361220227 no 259 0.103000521899892 138 5402031
SGTC_1147 3809-1045 12.3 µM 1.2623858291094 0.0683135085991485 no 260 0.103404992933543 138 325925
SGTC_2316 5844804 197.44 µM 1.26020142028862 0.0686415396030158 no 261 0.103798355319539 152 776813
SGTC_25 0118-0223 35.662 µM 1.25814039878281 0.0689521541840936 no 262 0.104170492628471 125 5333628
SGTC_2196 6573537 42.6665 µM 1.24963216085818 0.0702459015114297 no 263 0.105716974596437 143 2903087
SGTC_80 0159-0065 512.242 µM 1.24901435328085 0.0703405663764409 no 264 0.105829912057188 89 1548079
SGTC_1016 4226-1401 38 µM 1.2471581374398 0.0706255791127765 no 265 0.106169759598517 143 2901613
SGTC_206 4546-0025 72.014 µM 1.24449452324344 0.0710361133998198 no 266 0.10665880689582 135 6620745 YIL048W NEO1
SGTC_3269 9137823 49.47 µM 1.24410252248847 0.0710966856100038 no 267 0.106730916398127 106 17682936
SGTC_473 2-arachidonoylglycerol 10 µM 1.24129718522973 0.0715313263288285 no 268 0.107247992068141 141 5282280 An endocannabinoid.
SGTC_1384 3089-0840 101 µM 1.23185169205319 0.0730097472584914 no 269 0.109002244809369 100 1069836
SGTC_2859 9028643 45.46 µM 1.23124031983896 0.0731062399457676 no 270 0.109116497737059 100 17151580
SGTC_294 k038-0071 157 µM 1.22943904768446 0.0733911015145592 no 271 0.109453618803783 151 24152826
SGTC_533 1222-0222 6.71 µM 1.22801063724515 0.0736175999265536 no 272 0.109721487431431 148 3982874
SGTC_3226 9131256 49.47 µM 1.2240960176184 0.0742410676846389 no 273 0.110458004089133 116 17178073
SGTC_2724 maprotiline 69.64 µM 1.22314167148694 0.0743936726943496 no 274 0.110638095826693 133 4011 A tricyclic antidepressant.
SGTC_1868 st057644 42.7 µM 1.22063803795849 0.0747951552354899 no 275 0.111111548782757 129 688665
SGTC_2870 9038528 12.99 µM 1.21968759914919 0.0749479997149767 no 276 0.111291662176139 126 6463316
SGTC_1927 st060202 13.8 µM 1.21740143450808 0.0753166241180815 no 277 0.111725758765678 133 688887
SGTC_2212 7123476 200 µM 1.21531490905561 0.0756542632318503 no 278 0.112123003858056 109 1085715
SGTC_45 0kpi-0036 14.9 µM 1.2152607254446 0.0756630464965933 no 279 0.112133333087749 139 2795021
SGTC_2251 lansoprazole 556 µM 1.21264492443618 0.0760879973886121 no 280 0.112632802577086 129 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1685 st024049 53.0905 µM 1.21021524999694 0.076484336319329 no 281 0.113098153924184 142 1941139
SGTC_385 1494-0393 12.4 µM 1.21019438519879 0.0764877466632582 no 282 0.113102156055534 140 3090647
SGTC_1809 st050081 57.6 µM 1.20944677677031 0.0766100193433506 no 283 0.113245623466492 143 5036894
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.20456030424517 0.0774128747162759 no 284 0.114186544393346 147 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_40 0327-0103 19.753 µM 1.20347880841066 0.0775914268495772 no 285 0.114395543575015 127 409036
SGTC_1041 0206-0046 107 µM 1.20187797616084 0.0778562938008624 no 286 0.114705404257758 140 50494
SGTC_650 1328-0195 38 µM 1.20083777330943 0.0780287688152283 no 287 0.114907068094734 139 2780821
SGTC_3133 9127736 49.47 µM 1.20035664662854 0.0781086419393746 no 288 0.115000429239151 132 27243420
SGTC_818 4072-2707 53.5 µM 1.20033034080693 0.0781130108266217 no 289 0.115005535357434 121 882871
SGTC_213 1246-0773 967 nM 1.19854818099518 0.0784094249228064 no 290 0.115351838851019 120 6251622
SGTC_2891 9063876 19.48 µM 1.19662459048768 0.0787303183620145 no 291 0.115726455686935 111 6472478
SGTC_1716 st033144 30.6155 µM 1.1961634869001 0.078807387339863 no 292 0.115816383281561 144 674617
SGTC_821 1114-0266 29.2 µM 1.19553289085639 0.0789128778530013 no 293 0.115939446783949 145 3123235
SGTC_1215 3852-0577 11.2 µM 1.19268940357087 0.0793898852976153 no 294 0.116495518565623 132 2884876
SGTC_2373 9071805 200 µM 1.18898592666569 0.0800144280363692 no 295 0.117222602478883 139 10149009
SGTC_2766 oltipraz 83.91 µM 1.1885668757181 0.0800853287661954 no 296 0.117305074517467 152 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_485 niflumic acid 177 µM 1.18819887625292 0.0801476310719343 no 297 0.117377533165269 125 4488 A COX2 inhibitor.
SGTC_229 benomyl 22.8748 µM 1.18683801649784 0.0803783428872508 no 298 0.117645760107099 130 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2566 crystal violet carbinol 226 nM 1.18524604734532 0.0806488720401226 no 299 0.117960089245586 179 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_739 1486-1183 203 µM 1.18514458875852 0.0806661365508418 no 300 0.117980142033645 125 4346692
SGTC_110 0850-0284 111.64 µM 1.18163587880504 0.0812649083690666 no 301 0.11867510542076 114 3906265
SGTC_2736 butenafine 14.65 µM 1.17333161665379 0.0826954070594872 no 302 0.120331424112857 141 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.17222791524756 0.0828869494550118 no 303 0.120552781829659 150 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2716 st080858 38.6235 µM 1.17220526241002 0.0828908842452355 no 304 0.120557328070593 132 5296050
SGTC_63 0099-0242 26.702 µM 1.16576131626711 0.0840159102820472 no 305 0.121855480756633 175 3898502 YLR359W ADE13
SGTC_3257 9139206 32.98 µM 1.16418079964617 0.0842935899976115 no 306 0.122175374781574 146 4910041
SGTC_1221 2958-7315 257 µM 1.16299165071799 0.0845029642594462 no 307 0.122416444982148 157 4562705
SGTC_1844 rapamycin 4 nM 1.16186288353581 0.0847020677728327 no 308 0.122645582935073 177 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2483 5729050 27.16 µM 1.16007577757863 0.0850180149521056 no 309 0.123008977582451 151 2865180
SGTC_2310 7668677 200 µM 1.15215201442012 0.086429524909984 no 310 0.124629306098475 180 2197143
SGTC_1524 corynanthine 62.1 µM 1.15156980530177 0.0865339244350629 no 311 0.124748947552456 145 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2708 st078559 56 µM 1.14910227629586 0.0869774389523719 no 312 0.125256904945372 116 17250902
SGTC_2219 9098279 200 µM 1.14767541606357 0.0872346769424408 no 313 0.12555129178702 110 902349
SGTC_2692 st077426 47.7 µM 1.14574185563749 0.0875841700028484 no 314 0.125950989894486 157 25238571
SGTC_3216 9129716 49.47 µM 1.1439577576958 0.08790757338728 no 315 0.126320578008342 139 8056934
SGTC_2898 9056270 58.44 µM 1.14185694963068 0.0882895275762118 no 316 0.126756742853097 104 19154699
SGTC_1379 2144-0755 36.5 µM 1.14109189061889 0.0884289320376512 no 317 0.126915842786814 168 5392327
SGTC_1363 1636-0063 10.4 µM 1.1409486414835 0.0884550522545442 no 318 0.126945647995405 177 6072185
SGTC_2259 7964009 200 µM 1.1409390857704 0.0884567948590834 no 319 0.126947636383332 129 313134
SGTC_2311 7694451 200 µM 1.13907247717789 0.0887976851338184 no 320 0.127336462948309 185 2163142
SGTC_1033 k072-0102 21.3 µM 1.13887662299333 0.0888335097238518 no 321 0.127377308600431 157 5965931
SGTC_587 k089-0003 57 µM 1.13513179367641 0.0895205652022847 no 322 0.128160051016744 134 9659696
SGTC_492 tmb-8 126 µM 1.13283398425097 0.0899440910098866 no 323 0.12864198852649 140 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2667 digitoxin 100 µM 1.13280487276933 0.089949466292381 no 324 0.128648102361224 116 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_653 0203-0016 55.2 µM 1.13254996071929 0.0899965446639414 no 325 0.128701646213466 166 295302
SGTC_576 1073-0113 22.7 µM 1.13186360966621 0.0901233942595761 no 326 0.128845889967683 189 5439563
SGTC_2711 st079103 59.1 µM 1.13161964434335 0.0901685152720845 no 327 0.128897188800926 142 54693780
SGTC_597 k018-0003 82.8 µM 1.12642282757183 0.0911336484746666 no 328 0.129993294450082 164 6786234
SGTC_1644 st010134 20.9 µM 1.12524008956026 0.0913543684282547 no 329 0.130243654635893 174 3818134
SGTC_201 4262-0159 12.803 µM 1.12185161200894 0.0919889123384898 no 330 0.130962768674577 152 1341029
SGTC_422 cantharidin 155 µM 1.12124180023813 0.0921034545663545 no 331 0.131092475705748 160 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2368 9071271 200 µM 1.12062655051323 0.0922191251925312 no 332 0.13122342929766 152 27209959
SGTC_2839 9003951 25.97 µM 1.11557746956698 0.0931724473003206 no 333 0.132301520331573 144 2990634
SGTC_2396 5342950 42.78 µM 1.11453398440114 0.0933703736598776 no 334 0.132525086706911 206 1886677
SGTC_1023 4482-3888 16 µM 1.11128804920437 0.0939880423708063 no 335 0.133222190901531 176 3303168
SGTC_490 phenamil 164 µM 1.10915032285423 0.0943964736878924 no 336 0.133682669454188 160 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2014 4013930 200 µM 1.10655764185002 0.0948935824944571 no 337 0.134242614733496 181 64556
SGTC_2009 4012297 12.05 µM 1.10496014623719 0.0952008378135172 no 338 0.134588429254399 149 45595307
SGTC_2794 7785382 27.27 µM 1.10471600905132 0.0952478585532319 no 339 0.134641332155728 163 2205081
SGTC_3016 9080866 49.47 µM 1.10450125276187 0.0952892346774668 no 340 0.134687880209864 161 17066299
SGTC_2380 9035439 200 µM 1.1043644469374 0.0953155993370359 no 341 0.134717538393279 150 6462575
SGTC_2266 7929956 200 µM 1.10366933638483 0.0954496411739968 no 342 0.134868300889225 170 2967153
SGTC_939 1165-0479 45.3 µM 1.10071740601262 0.0960204233791126 no 343 0.135509834149151 157 1377347
SGTC_1301 naphtanilide LB 4.81 µM 1.10065115603932 0.0960332621392903 no 344 0.135524255987151 178 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1489 4065-0444 182 µM 1.09892885342565 0.0963674748785923 no 345 0.135899550043453 151 2877968
SGTC_2055 5235184 200 µM 1.09883022456559 0.0963866396473976 no 346 0.135921063040439 156 2836034
SGTC_2348 9022543 33.42 µM 1.09688686258515 0.0967648296197142 no 347 0.136345426175811 188 3162678 YDL140C RPO21
SGTC_2965 9082772 38.63 µM 1.09480651091194 0.0971708850539419 no 348 0.136800706694994 110 16459634
SGTC_179 1273-0063 6.77 µM 1.09183211538116 0.0977536152449036 no 349 0.13745345009271 142 3108139
SGTC_3194 9111903 49.47 µM 1.0911346446472 0.0978906306245532 no 350 0.137606820205885 162 17087251
SGTC_3266 9136860 49.47 µM 1.09052754135089 0.0980100082145589 no 351 0.137740414050219 178 4871271 YPR165W RHO1
SGTC_1402 3909-7673 35.9 µM 1.09004044779838 0.0981058648258129 no 352 0.137847663569815 157 5328014
SGTC_1984 st072354 53.1 µM 1.08636213667741 0.0988319494015065 no 353 0.138659403118383 165 5762938
SGTC_1938 st074717 56.4 µM 1.08542188219409 0.0990181815005331 no 354 0.138867422511372 164 17250979
SGTC_2983 9022671 12.99 µM 1.08502708968323 0.0990964528003729 no 355 0.138954828667237 161 6405161
SGTC_1884 5633444 25 µM 1.08486205662979 0.0991291855520586 no 356 0.138991377705806 168 5724239
SGTC_1503 4585-0012 61.3 µM 1.08305277043847 0.0994885590865203 no 357 0.139392500391759 150 2922052
SGTC_2497 7-hydroxyflavone 100 µM 1.08075241104132 0.0999468469130193 no 358 0.139903631201813 182 5281894
SGTC_2700 st077718 96.8 µM 1.07977353012089 0.100142330840085 no 359 0.140121520566365 165 904970
SGTC_1372 2752-0194 270 µM 1.07659803870723 0.100778402299096 no 360 0.140829940410064 146 823334
SGTC_2103 5378138 10 µM 1.07509301183567 0.101080895911654 no 361 0.141166543922386 164 244142
SGTC_1875 nocodazole 6 µM 1.07083679313112 0.101939929334596 no 362 0.142121410056574 175 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_350 k064-0020 19.8 µM 1.07008598763521 0.102092014200407 no 363 0.142290302874595 168 2790705
SGTC_2886 9058944 51.95 µM 1.06997612451812 0.102114282160921 no 364 0.142315027838982 113 4949929
SGTC_443 clozapine 122 µM 1.06813873000743 0.102487224273837 no 365 0.142728968824164 162 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1073 triclabendazole 3.09 µM 1.06606780968721 0.102908751868495 no 366 0.143196494927844 169 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2074 5212007 75.395 µM 1.05921945432833 0.104311674955768 no 367 0.144749923553881 167 758611
SGTC_1559 coumarin 343 70.1 µM 1.05804916713262 0.104552794863259 no 368 0.145016513750673 154 108770 A hepatotoxic, DNA x-linker.
SGTC_3329 9141233 27.5565 µM 1.05798391113368 0.104566251746052 no 369 0.145031388720872 168 4909101 YNL103W MET4
SGTC_2523 spermine 47.74 µM 1.05335684298848 0.105523631950192 no 370 0.146088737934226 150 1103 A DNA binding polyamine.
SGTC_1202 1988-0068 29.6 µM 1.05202431823101 0.105800514824767 no 371 0.146394196298182 150 2850480
SGTC_1022 4477-0945 21.3 µM 1.05176577849531 0.105854297097526 no 372 0.146453511716009 159 4648966
SGTC_271 rotenone 740 µM 1.05076996523007 0.106061634026312 no 373 0.146682126668283 162 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1631 benzylvanillin 81.9 µM 1.04902552945919 0.106425547549984 no 374 0.147083184358045 152 75506
SGTC_1263 0774-1208 64.8 µM 1.04859289742553 0.106515939962429 no 375 0.147182763093705 197 906585
SGTC_1403 3909-7815 62.9 µM 1.04636877814191 0.106981513535961 no 376 0.147695400980753 170 6615483
SGTC_2296 7971656 126.45 µM 1.04422317263036 0.107432041273672 no 377 0.148191074125818 153 666570
SGTC_596 1155-0152 116 µM 1.04390731245032 0.107498479942004 no 378 0.148264137338914 189 280313
SGTC_3062 9077494 49.47 µM 1.04345517576031 0.107593634809586 no 379 0.148368765290924 159 16459633
SGTC_2885 9057732 51.95 µM 1.04315292511994 0.107657279100873 no 380 0.148438735978432 201 6471414
SGTC_1157 4092-0394 27.6 µM 1.042693200371 0.107754134385306 no 381 0.148545204050635 153 3659885
SGTC_2570 licareol 100 µM 1.04143137892807 0.108020298776339 no 382 0.148837692773159 162 443158
SGTC_1825 st052143 62.6 µM 1.04103591610414 0.108103813729151 no 383 0.148929439746485 167 674173
SGTC_108 0509-0257 621.132 µM 1.04100153390285 0.10811107685504 no 384 0.148937418167309 176 536624
SGTC_2235 salicylic acid 500 µM 1.04047942468078 0.108221413870135 no 385 0.149058609177651 173 338 A COX inhibitor and kinase inhibitor.
SGTC_2576 guaiol 23.12 µM 1.03927494774608 0.108476264344769 no 386 0.14933844130078 174 227829
SGTC_934 2950-0684 338 µM 1.03747964678625 0.108856925879761 no 387 0.14975618819131 178 1121253
SGTC_2899 9053889 58.44 µM 1.03578930429604 0.109216209780995 no 388 0.150150224241105 171 6470052
SGTC_1477 0139-0234 16 µM 1.03517222532907 0.109347582563072 no 389 0.150294243676987 181 620880
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.03513003914155 0.10935656791843 no 390 0.150304092829292 181 390807
SGTC_220 paclitaxel 373.376 µM 1.03134812258349 0.110164245283024 no 391 0.151188799543776 151 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_612 0302-0167 22.4 µM 1.02847687810229 0.11078028790963 no 392 0.151862780894098 194 235821
SGTC_547 1120-0019 610 nM 1.02824844235292 0.11082940595543 no 393 0.151916488335895 175 3676939
SGTC_2054 5233173 129 µM 1.02731803935542 0.111029621547568 no 394 0.152135365372768 117 6889
SGTC_2152 5568786 200 µM 1.02688275419629 0.111123380471798 no 395 0.152237837948531 185 5399883
SGTC_2269 7935389 174.42 µM 1.02600292228014 0.111313066323794 no 396 0.152445103308247 176 97605
SGTC_3297 9117502 71.43 µM 1.02158571041297 0.112268890687791 no 397 0.153488511854788 139 7453720
SGTC_1428 4049-0204 61.7 µM 1.02079885375925 0.112439769366721 no 398 0.153674873798834 193 X1428
SGTC_2370 9071495 200 µM 1.02019160830257 0.112571769534244 no 399 0.153818798361973 186 21791103
SGTC_1972 st070201 17.4 µM 1.01790287046613 0.113070279287967 no 400 0.154362058683538 168 2829099
SGTC_3204 9114183 49.47 µM 1.01747409453273 0.113163845873698 no 401 0.154463974895674 167 17027248
SGTC_1211 1056-0033 32.3 µM 1.01742628603984 0.113174281965125 no 402 0.154475341303477 189 6741922
SGTC_2532 xanthone 78.9 µM 1.01682334090919 0.113305957492047 no 403 0.154618738190971 156 7020 An insecticide.
SGTC_439 amiodarone 34.4 µM 1.01300866670044 0.114141566863567 no 404 0.155528010646437 177 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1673 st016611 27.3 µM 1.01243190577838 0.114268288104383 no 405 0.155665794766402 209 5226799
SGTC_1924 st058459 75.1 µM 1.01190827411835 0.114383422951615 no 406 0.155790956381107 170 688683
SGTC_800 3448-7362 155 µM 1.01100390468265 0.114582467949589 no 407 0.156007280471553 219 15991913
SGTC_1808 st050063 61.5 µM 1.01065360813074 0.114659631815611 no 408 0.156091124156054 176 4011993
SGTC_2998 9066762 71.4286 µM 1.00808852950764 0.115225798224156 no 409 0.156705981883826 167 4945196
SGTC_3168 9103419 49.47 µM 1.00708240691558 0.115448412240875 no 410 0.15694758743287 179 16649256
SGTC_1343 1487-0095 224 µM 1.00441456045487 0.116040177310774 no 411 0.157589417336467 205 4560101 YGL055W OLE1
SGTC_224 benfluorex 43.875 µM 1.00440837090327 0.116041552737466 no 412 0.157590908419786 183 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2256 7954252 200 µM 1.00288876579773 0.116379585858491 no 413 0.157957266795968 183 2972920
SGTC_3328 9140624 29.0385 µM 1.00187022391532 0.116606549147441 no 414 0.158203137670446 183 4904392
SGTC_686 1319-0111 510 µM 0.999708725790115 0.11708923858627 no 415 0.158725744027535 188 4562600
SGTC_278 4092-0821 23.9 µM 0.998027541528185 0.117465645493524 no 416 0.159133001841394 173 877900
SGTC_2771 fluoxetine 41.05 µM 0.990587422348015 0.119141726759154 no 417 0.160943540900858 173 3386 A selective serotonin reuptake inhibitor.
SGTC_2207 7258803 200 µM 0.98856017416742 0.119601329981592 no 418 0.161439189838193 189 3666799
SGTC_895 0964-0006 13.7 µM 0.985631463655408 0.120267512400502 no 419 0.16215699623232 223 6738897
SGTC_635 k038-0028 24.7 µM 0.985554059192337 0.120285154681928 no 420 0.162175995669611 193 4035102
SGTC_2201 6605497 169.863 µM 0.984562795951761 0.120511247869325 no 421 0.162419435922166 190 670741
SGTC_1376 2910-0861 41.3 µM 0.983672064031565 0.120714666413926 no 422 0.162638389868008 204 1112859
SGTC_1989 st071868 50.2 µM 0.980725416929846 0.121389321099574 no 423 0.163364083185864 195 16414057
SGTC_491 tetrandrine 80.3 µM 0.980456766280435 0.121450962081372 no 424 0.163430350306535 173 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3073 9114972 49.47 µM 0.979444315921241 0.121683463106 no 425 0.163680244775204 163 41905075
SGTC_3251 9135047 49.47 µM 0.978881907029699 0.121812750797358 no 426 0.163819166468553 160 17682963
SGTC_2205 7238770 200 µM 0.978297939027917 0.121947096636762 no 427 0.163963494475795 174 279867
SGTC_2625 euphol 100 µM 0.975879916371957 0.122504486812503 no 428 0.164561987859585 205 6708538 A triterpene alcohol.
SGTC_1322 1348-1070 12 µM 0.974854099517637 0.122741492097875 no 429 0.164816318605646 197 6758089
SGTC_628 1636-0253 16 µM 0.974364209566721 0.122854789931945 no 430 0.164937866787197 210 4456143
SGTC_1618 st003135 44.5 µM 0.973783217233999 0.122989252232815 no 431 0.165082093899595 204 1270615
SGTC_2438 5259590 200 µM 0.972918496769501 0.123189570317656 no 432 0.165296905595641 187 1201127
SGTC_98 0074-0023 107.663 µM 0.971039756001775 0.123625580527851 no 433 0.165764240796293 164 3563821
SGTC_2466 5983409 37.09 µM 0.970795730415667 0.123682292151819 no 434 0.165825004577979 187 2879657
SGTC_669 0108-0021 26.2 µM 0.968912432660497 0.124120583956426 no 435 0.166294440887049 212 17201
SGTC_2288 7946289 167.31 µM 0.967205877797907 0.12451868060115 no 436 0.166720562214599 192 1246052
SGTC_1487 3970-0795 2.82 µM 0.965179630987091 0.124992511496182 no 437 0.167227423686463 187 3765103
SGTC_1691 st019933 84.6 µM 0.960599755016038 0.126068136502363 no 438 0.168376725960353 213 6176082
SGTC_1797 st048695 56.8 µM 0.957077341362832 0.12689978535665 no 439 0.169264109664256 214 592262 YIL048W NEO1
SGTC_314 1671-0008 2.74 µM 0.956228993581769 0.127100651320446 no 440 0.169478277394398 209 3913060
SGTC_786 4544-0069 423 µM 0.955267711840999 0.12732852427326 no 441 0.169721165665327 197 748821 YLR208W SEC13
SGTC_604 1000-0114 314 µM 0.952087085920524 0.128084520332561 no 442 0.170526408930737 206 1572745
SGTC_3084 9116877 49.47 µM 0.95088938327265 0.128370006152202 no 443 0.170830265892938 176 27241325
SGTC_585 0kpi-0023 191 µM 0.949043493466253 0.12881085917917 no 444 0.171299245861244 158 64601
SGTC_1119 parthenolide 318.541 nM 0.948369575591203 0.12897207209226 no 445 0.171470671173887 218 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1036 k216-0215 33.5 µM 0.944523760031858 0.12989473565762 no 446 0.172451033009528 175 622330
SGTC_3160 9100216 49.47 µM 0.943246409711384 0.130202197941967 no 447 0.172777440013759 197 17191039
SGTC_2321 7390090 138.78 µM 0.939334682654416 0.131146893883505 no 448 0.173779468495338 175 649046
SGTC_641 4092-0595 30 µM 0.934487574061876 0.132324041796321 no 449 0.17502622137682 200 786260
SGTC_26 0302-0163 425.158 µM 0.933787412641613 0.132494680060177 no 450 0.175206781884605 234 3100915
SGTC_1602 st001878 87.6 µM 0.933490121469899 0.132567179545647 no 451 0.175283484271467 218 595405 YLR310C CDC25
SGTC_1548 st061468 90.8 µM 0.933420936605893 0.132584055365617 no 452 0.175301337314377 195 390799
SGTC_894 0960-0238 55.9 µM 0.932881350891775 0.132715723830731 no 453 0.175440616101291 223 6741907 YDL195W SEC31
SGTC_2861 9024595 19.48 µM 0.931913195297857 0.132952196637112 no 454 0.175690693867951 163 16482810
SGTC_1416 3966-0321 25.3 µM 0.927166622670689 0.134115747205128 no 455 0.176920014792912 203 582530 YLR208W SEC13
SGTC_1058 3448-5425 97.3 µM 0.926589357502151 0.134257730708294 no 456 0.177069891317504 214 7279705
SGTC_937 3122-0005 46.7 µM 0.926101430206168 0.134377821246292 no 457 0.177196635403446 213 759535
SGTC_3042 9091578 49.47 µM 0.926072957428847 0.13438483135243 no 458 0.177204033266415 190 25236497
SGTC_1700 st030840 7.9285 µM 0.925801247067475 0.134451740109012 no 459 0.177274639494615 222 5499307
SGTC_307 1501-1223 22.3 µM 0.918059059023758 0.136367870825855 no 460 0.179293973646184 185 2830329
SGTC_2493 resveratrol 26.09 µM 0.917494084860727 0.136508425236953 no 461 0.179441895563323 175 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2873 9040596 71.43 µM 0.917175409202448 0.136587749136728 no 462 0.179525365271308 210 6463863
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.915998411428031 0.136880997475623 no 463 0.179833864052274 185 1241132 A phosphatase inhibitor.
SGTC_2358 9037157 4 µM 0.915619865559738 0.136975403354441 no 464 0.179933154118366 220 2388925
SGTC_1686 st019653 115.5 µM 0.915516363937878 0.13700122345678 no 465 0.179960307898362 213 97252
SGTC_2393 9031399 185.94 µM 0.91396734337333 0.13738804829504 no 466 0.180367002783935 204 1526623 YDL150W RPC53
SGTC_965 1291-5240 308 µM 0.913852150048167 0.137416844390034 no 467 0.180397269776348 209 2834598
SGTC_2973 9094665 17.96 µM 0.910638928933947 0.138221748265366 no 468 0.181242825952787 224 25237061 YIL048W NEO1
SGTC_2463 5473429 200 µM 0.910398032510963 0.138282221475653 no 469 0.181306317486869 204 5399405
SGTC_1845 st056753 3.01 µM 0.90945836972771 0.138518281224955 no 470 0.18155411151381 206 5375839
SGTC_3076 9116187 49.47 µM 0.907888677599186 0.138913227537573 no 471 0.181968520114474 194 27241210
SGTC_2278 7948257 134.34 µM 0.906806393110141 0.139185984596952 no 472 0.182254594262754 202 1247028
SGTC_1299 1079-1439 3.74 µM 0.90391048614045 0.139917601768202 no 473 0.183021434190898 205 323161
SGTC_1907 st060210 83.7 µM 0.903586434859364 0.139999631846781 no 474 0.183107368452527 220 688793
SGTC_1853 st056710 91.2 µM 0.902772338691106 0.140205855643346 no 475 0.183323367384091 208 269167
SGTC_1982 st072467 71.9 µM 0.900557995078784 0.140767828394824 no 476 0.183911688369799 211 3163533
SGTC_1748 st037455 53.6035 µM 0.899222468593225 0.141107506249457 no 477 0.184267087369903 201 580690
SGTC_2918 7977171 22.06 µM 0.898369977815021 0.141324619178964 no 478 0.184494168312058 209 2236483
SGTC_1454 4239-0054 42.6 µM 0.893625446730814 0.142537095383809 no 479 0.185761163287585 203 1340767
SGTC_1401 3807-4679 7.6 µM 0.893278308204304 0.142626082825394 no 480 0.185854075700171 220 3291456
SGTC_2490 carminic acid 95.39 µM 0.893109917028026 0.142669262694356 no 481 0.185899156359201 206 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1652 st011932 78 µM 0.890681227318225 0.143293024854955 no 482 0.186550104343334 215 1551076
SGTC_2650 prasterone 100 µM 0.89037131103233 0.14337275318324 no 483 0.186633270888321 182 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_985 1493-0307 8.71 µM 0.88883525680305 0.143768356939129 no 484 0.18704581232922 214 3278274
SGTC_2255 7941087 197.44 µM 0.887606879682182 0.144085249376911 no 485 0.187376125855724 202 935561
SGTC_3069 9117009 49.47 µM 0.886607307600204 0.144343462816311 no 486 0.187645179082614 194 41904981
SGTC_2130 NSC 7 2.4545 µM 0.886523718734636 0.144365069947116 no 487 0.187667689373704 207 21448
SGTC_2073 5212005 126 µM 0.884762365922104 0.144820874127087 no 488 0.18814240553771 223 691789
SGTC_2925 9010536 32.5 µM 0.883429203916458 0.145166514432201 no 489 0.188502208883168 192 2994177
SGTC_2237 6667747 47.222 µM 0.882194249995502 0.145487187870916 no 490 0.188835885435491 212 729940 YDL015C TSC13
SGTC_1784 st039334 36.3 µM 0.881737354655954 0.145605947917722 no 491 0.188959427780885 236 3496984
SGTC_3215 9129942 49.47 µM 0.880311103359483 0.14597709027775 no 492 0.189345399620316 234 17682944
SGTC_1935 st074532 41.6 µM 0.879811357926094 0.146107285423427 no 493 0.189480755359155 232 2829742
SGTC_1655 st012546 55.1 µM 0.877531847256277 0.146702139361608 no 494 0.19009891429693 201 720985 YLR208W SEC13
SGTC_2627 acetyl isogambogic acid 100 µM 0.877414868490736 0.146732709546501 no 495 0.190130670057591 207 6857789 A caspase activator and apoptosis inducer.
SGTC_1382 3002-2117 298 µM 0.876775542836696 0.146899860707484 no 496 0.190304282837805 231 1497314
SGTC_3164 9100705 49.47 µM 0.874939337056638 0.147380645111365 no 497 0.190803456947474 179 17174235
SGTC_1886 st057356 49.9 µM 0.87303919795817 0.147879278530819 no 498 0.191320856385502 191 24207747
SGTC_2849 9019321 12.99 µM 0.871114230071834 0.148385577896594 no 499 0.191845892524504 216 16489627
SGTC_1293 1000-1278 195 µM 0.870820602486576 0.148462908748249 no 500 0.191926057090231 221 678847
SGTC_83 0170-0301 39.027 µM 0.870426894042865 0.148566639554687 no 501 0.192033577345884 207 3089716
SGTC_200 k038-0079 37.545 µM 0.868641934755353 0.149037532539198 no 502 0.192521505061596 228 3436683
SGTC_1495 4469-0029 237 µM 0.866911109388774 0.149495095487829 no 503 0.192995358017553 210 793680
SGTC_1948 st076329 66.6 µM 0.865688520629185 0.149818864883518 no 504 0.19333049843153 214 24208413
SGTC_1776 st049249 45.9 µM 0.861143349859468 0.15102662870742 no 505 0.194579548115209 226 1822314
SGTC_1933 st074711 15.9 µM 0.860813698583482 0.151114476471538 no 506 0.194670329550932 237 17250958
SGTC_801 0866-0028 10.1 µM 0.859588802399037 0.151441193139593 no 507 0.195007874852057 227 6849771
SGTC_1908 st060353 56.5 µM 0.856717012990337 0.152209026019331 no 508 0.195800649315217 243 4227716
SGTC_900 1112-0045 141 µM 0.856516056668096 0.152262852484837 no 509 0.195856197625887 206 56211 YIL048W NEO1
SGTC_99 0109-0120 622.8 µM 0.855839924972216 0.152444048194253 no 510 0.196043164032921 230 759414
SGTC_549 1661-1316 519 µM 0.854861015208948 0.152706638500746 no 511 0.196314047497575 230 2857282
SGTC_1856 st057054 55.7 µM 0.853356236622897 0.153110876671417 no 512 0.196730891358021 234 1266018
SGTC_1878 temozolomide 1 mM 0.851791055503854 0.15353209300819 no 513 0.197165035826432 215 5394 DNA alkylating agent.
SGTC_920 mycophenolic acid 780.421 nM 0.850430904063429 0.153898755069796 no 514 0.197542780243414 207 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3261 9137475 49.47 µM 0.850077423842682 0.153994139094212 no 515 0.197641021172812 156 17027690
SGTC_3233 9132340 49.47 µM 0.849699508796475 0.15409615993199 no 516 0.197746085803108 254 17682950
SGTC_851 0394-0702 453 µM 0.849590218209351 0.154125672031484 no 517 0.19777647610502 238 762646
SGTC_313 3474-0040 5.03 µM 0.848610782649612 0.154390319145196 no 518 0.198048952523321 241 1043375 YIL048W NEO1
SGTC_71 0417-1750 47.813 µM 0.846837644165021 0.154870191591412 no 519 0.198542811334723 207 6811472
SGTC_3207 9114163 49.47 µM 0.846421329696489 0.154983003311495 no 520 0.198658871837331 244 849233
SGTC_2829 7992743 58.44 µM 0.844411409961942 0.155528408971765 no 521 0.199219774322275 210 16462845
SGTC_199 4063-0024 41.6 µM 0.842851806171195 0.155952489673929 no 522 0.199655664959664 213 306215
SGTC_832 4083-0019 164 µM 0.841829916263976 0.156230770486027 no 523 0.199941581923664 240 1990758
SGTC_2025 5147754 141 µM 0.84155963056418 0.156304429294332 no 524 0.200017246943709 213 315777 YLR208W SEC13
SGTC_1604 st002052 72.4 µM 0.84117485961555 0.156409327310801 no 525 0.20012499118291 217 6254834 YHR062C RPP1
SGTC_829 1635-0120 117 µM 0.840024123664317 0.15672332281499 no 526 0.200447430408985 245 285054
SGTC_3291 9121177 71.43 µM 0.839538763765052 0.156855884829135 no 527 0.200583523031712 212 17015612
SGTC_1423 4048-0112 5.59 µM 0.838743750727884 0.157073178989778 no 528 0.200806560761198 217 X1423
SGTC_1946 st076057 65.1 µM 0.838178470749047 0.157227802541942 no 529 0.200965238301083 207 953009
SGTC_1761 st044296 37 µM 0.834122962477997 0.158340057512952 no 530 0.202105848377674 243 1826700
SGTC_1702 st027038 51 µM 0.833940756660999 0.158390149768842 no 531 0.202157184457004 216 5521182
SGTC_1635 st007035 42.4 µM 0.832967357631017 0.158657933976165 no 532 0.202431569592356 227 3716403
SGTC_1359 1582-0056 520 nM 0.831435424442922 0.1590799730127 no 533 0.202863847029427 228 3661189
SGTC_3325 9138760 55.175 µM 0.829566084122105 0.159595961223163 no 534 0.20339207954025 226 43844959
SGTC_2760 etidronate 98.04 µM 0.828133466826796 0.159992142694674 no 535 0.203797459091432 227 3305 A chelator and antioxidant.
SGTC_3310 9130229 44.1445 µM 0.825674525836292 0.160673645688005 no 536 0.204494373303933 218 7761258
SGTC_335 4077-0256 27.6 µM 0.825459228382684 0.160733406166231 no 537 0.204555460464679 238 3121989
SGTC_919 tnp00227 403.569 nM 0.824127603614852 0.161103349969031 no 538 0.204933528610461 232 1269246 A methoxyflavone. YNL221C POP1
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.823417511347029 0.161300850387843 no 539 0.205135304124559 227 4213774
SGTC_2384 9036245 200 µM 0.821779450869652 0.161757051913776 no 540 0.205601215523627 201 6462766
SGTC_3048 9093155 49.47 µM 0.820614442322002 0.162082019155666 no 541 0.205932959308558 216 25236002
SGTC_1971 st069429 63.5 µM 0.818506093328634 0.162671201803703 no 542 0.206534132065432 219 1246522 YGL099W LSG1
SGTC_1178 0988-0033 191 µM 0.818247103827209 0.162743672937627 no 543 0.206608051728049 225 5392207
SGTC_2429 5902844 64.44 µM 0.814659536355717 0.163749715364061 no 544 0.207633610558383 236 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1882 5615643 20 µM 0.814337287028905 0.163840279198057 no 545 0.207725877248276 217 2253075
SGTC_2107 5363541 170.161 µM 0.814024076601939 0.163928333916397 no 546 0.207815579119465 226 244052
SGTC_2640 pentamidine 10.38 µM 0.813180784730737 0.164165566207985 no 547 0.208057207306259 238 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_938 3126-1755 342 µM 0.811332822453232 0.164686207495852 no 548 0.208587282939333 224 1777771
SGTC_2856 9022925 19.48 µM 0.810518469162359 0.164915981024036 no 549 0.208821127247906 232 4944862
SGTC_1267 0828-0272 9.49 µM 0.80824382047737 0.165558882877121 no 550 0.209475118103394 229 745334
SGTC_2027 5150920 200 µM 0.807529051785857 0.165761237836859 no 551 0.209680871879966 226 786715
SGTC_2815 7968870 71.43 µM 0.80730893168802 0.165823587241085 no 552 0.209744259720201 221 2977326 YHR190W ERG9
SGTC_1331 1472-0049 76.2 µM 0.80674175122153 0.16598431195169 no 553 0.209907642215273 258 24051409
SGTC_866 0495-0101 262 µM 0.806661273355488 0.166007125512037 no 554 0.209930830797041 218 635694
SGTC_2837 9008476 45.46 µM 0.805007334360855 0.166476426541178 no 555 0.210407723705713 224 2992805
SGTC_1753 st043925 64 µM 0.804612490453185 0.166588589026042 no 556 0.210521666040282 232 670181
SGTC_1240 0356-0016 42.1 µM 0.804154350108043 0.16671879311289 no 557 0.21065391956045 226 4305613
SGTC_132 0417-1715 25.805 µM 0.804062499078254 0.166744905196208 no 558 0.210680440492521 231 6769098
SGTC_1266 0828-0227 32.9 µM 0.803143298964061 0.167006367468854 no 559 0.210945956862362 236 3913820
SGTC_695 3505-6186 243 µM 0.802993346336077 0.167049045879261 no 560 0.210989290168396 247 1819379
SGTC_847 0342-0274 5.54 µM 0.801837617010887 0.167378216990632 no 561 0.211323447862108 235 18097
SGTC_2340 7987427 183.45 µM 0.80154498232801 0.167461630532156 no 562 0.21140810691184 226 2239331
SGTC_1260 0700-1617 7.75 µM 0.800886943332075 0.167649297917226 no 563 0.211598549760915 235 2853078
SGTC_858 0438-0351 2.77 µM 0.799076286068105 0.16816638151278 no 564 0.212123089564348 247 2799119
SGTC_2347 9049783 174.81 µM 0.798361900742205 0.168370676119045 no 565 0.212330252964151 261 6467988 YPL169C MEX67
SGTC_2262 9014885 67.46 µM 0.79816401398621 0.168427294521233 no 566 0.212387658716837 230 6457424
SGTC_1191 1487-1166 10.6 µM 0.79623065593539 0.168981101601083 no 567 0.212948991152685 254 3955771
SGTC_1174 0739-0097 51.1 µM 0.796091402547657 0.169021035601035 no 568 0.212989455467952 240 728447
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.79546351121733 0.169201172651522 no 569 0.213171964140179 243 165506
SGTC_673 1082-0474 110 µM 0.795293579755745 0.169249945828286 no 570 0.21322137366124 252 3098046
SGTC_2594 a-mangostin 100 µM 0.795224291244946 0.169269835381952 no 571 0.213241522006876 246 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_368 fentichlor 4.58 µM 0.79082125570639 0.170536821574788 no 572 0.214524152196865 246 7329 A pesticide.
SGTC_155 k072-0202 43.6 µM 0.790724264095652 0.170564799372723 no 573 0.214552456820632 254 5857737
SGTC_160 3453-0671 289.699 µM 0.790398811339802 0.170658699598826 no 574 0.214647448091376 259 5322268
SGTC_746 1095-0025 46.6 µM 0.786236782647809 0.171862452333522 no 575 0.215864390317837 254 6749286
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.785664827778048 0.172028297339337 no 576 0.216031937034315 241 688662
SGTC_2751 anetholtrithion 17.25 µM 0.785388531724626 0.172108449196293 no 577 0.216112901335502 237 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_539 4859-0462 2.54 µM 0.785197945286483 0.172163751087928 no 578 0.216168759995194 236 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1563 conessine 56.1 µM 0.784891617977355 0.172252660917612 no 579 0.21625855846891 229 441082 An anti-amoebic, histamine inhibitor.
SGTC_375 3970-0961 9.27 µM 0.784071978642823 0.172490700800656 no 580 0.216498938231687 247 2898222
SGTC_2143 5623677 140.463 µM 0.779143228488963 0.173926530579462 no 581 0.217947673993067 233 5375313
SGTC_884 0851-0618 334 µM 0.777698884659628 0.174348728607022 no 582 0.21837327493957 259 9642473
SGTC_2819 7996655 46.38 µM 0.777167827185707 0.174504126288637 no 583 0.218529880517708 219 6456960
SGTC_2362 9071156 126 µM 0.77507083393909 0.175118606204971 no 584 0.219148902383661 241 653133
SGTC_52 0329-0193 875 nM 0.774300368065756 0.175344719444479 no 585 0.219376593038095 259 3739292
SGTC_218 alverine citrate 93.75 µM 0.774277242645358 0.175351509060419 no 586 0.219383429240355 253 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1481 3346-2004 36 µM 0.773160809191875 0.175679491818275 no 587 0.21971360837754 275 2770522
SGTC_1508 1080-0625 72.9 µM 0.772914018285488 0.175752045797177 no 588 0.219786633935544 243 767111
SGTC_2978 9011784 42.97 µM 0.770953954433739 0.17632895823441 no 589 0.220367112393841 221 2994934
SGTC_2223 6903751 107.57 µM 0.768071904690192 0.177179415523626 no 590 0.221222233657525 242 5598863
SGTC_167 3672-0051 66.205 µM 0.765448759299349 0.177955721553509 no 591 0.222002183842978 233 3237971
SGTC_3342 9147791 14.508 µM 0.765006794446343 0.178086729544909 no 592 0.222133749372257 245 1838168
SGTC_1142 3253-1408 9.78 µM 0.764504401807554 0.178235723466373 no 593 0.222283357270958 250 256655
SGTC_1513 0337-0559 19 µM 0.764252399452601 0.178310489050036 no 594 0.222358422895777 248 775073
SGTC_2663 amphotericin b 100 µM 0.764049596404877 0.178370672235118 no 595 0.222418843694301 255 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1558 st069300 45.6 µM 0.763486603587288 0.178537811256618 no 596 0.222586624345164 243 24208000
SGTC_721 1187-1332 279 µM 0.762412747646426 0.178856886659624 no 597 0.222906850178401 254 25730
SGTC_219 mitoxanthrone 164.414 µM 0.761830033088695 0.179030179085022 no 598 0.223080726527827 255 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_204 PMA1.184 62.41 µM 0.761218414128758 0.179212180929709 no 599 0.223263310714373 267 2252213 YGL008C PMA1
SGTC_3060 1327-0027 12.5 µM 0.761110654138319 0.179244259544935 no 600 0.223295488688525 233 16000455 YPR107C YTH1
SGTC_2147 5545932 89.7195 µM 0.760631148667521 0.179387045280178 no 601 0.22343870476328 267 797404
SGTC_2300 7976697 71.57 µM 0.760368929767732 0.179465158294383 no 602 0.223517044969536 231 2236109
SGTC_2636 apigenin dimethyl ether 100 µM 0.759754886857082 0.179648160648212 no 603 0.223700556815429 254 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_151 3013-0144 2.285 µM 0.75937853707147 0.179760381589793 no 604 0.223813074416252 265 906558 YHR107C CDC12
SGTC_940 3232-1287 54.8 µM 0.758290549277339 0.180085048187518 no 605 0.224138531863486 238 1585493 YIL048W NEO1
SGTC_617 3770-0098 35 µM 0.757586362678903 0.180295380731422 no 606 0.224349323361133 257 5962639
SGTC_3293 9120939 62.045 µM 0.752672803612601 0.181767292575639 no 607 0.225823278311948 253 934087
SGTC_1281 0884-0031 11.8 µM 0.752227188121341 0.181901152488712 no 608 0.225957223064161 260 1548255
SGTC_2706 st078239 82.5 µM 0.751097399883958 0.182240809534615 no 609 0.226297020218657 257 15434492
SGTC_2629 bisabolol 100 µM 0.750997652947547 0.182270816264112 no 610 0.226327034148913 278 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3027 9089541 49.47 µM 0.747839765941184 0.183222394678176 no 611 0.227278406476578 254 9943819
SGTC_27 0485-0001 32.618 µM 0.747365724572495 0.183365506403094 no 612 0.227421414555398 250 2054479
SGTC_1251 0490-5699 265 µM 0.746994028672496 0.18347776905935 no 613 0.227533582654068 256 3883818
SGTC_989 1501-0895 10.3 µM 0.746464792491104 0.183637687238355 no 614 0.227693346035598 249 2830112
SGTC_511 blebbistatin 171 µM 0.746128464932079 0.183739359747529 no 615 0.227794907857803 244 3476986 A myosin inhibitor.
SGTC_2150 5556613 200 µM 0.746104871017368 0.183746493552336 no 616 0.227802033538465 270 743190
SGTC_2514 salinomycin 42.74 µM 0.742182902531153 0.184934728890099 no 617 0.228988263064378 269 23682228 A polyether potassium ionophore.
SGTC_2456 5770359 74.46 µM 0.741885439057952 0.18502504552819 no 618 0.229078374362139 277 3118787
SGTC_1620 st003704 16.5 µM 0.741254434405345 0.185216723513822 no 619 0.22926959189772 252 2834414
SGTC_2292 7671323 168.05 µM 0.741127348865278 0.185255342739619 no 620 0.229308114298138 279 937504
SGTC_1807 st050092 58.9 µM 0.740677475623234 0.185392092067099 no 621 0.229444509849399 253 5008496
SGTC_1079 idarubicin 2.36 µM 0.740075031813726 0.185575316849903 no 622 0.22962723394854 278 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1509 1326-1131 80 µM 0.739328995179008 0.185802369043126 no 623 0.229853623372008 229 768313
SGTC_2707 st078556 66.6 µM 0.739087468750343 0.185875913204319 no 624 0.229926942825057 245 17250899
SGTC_747 3448-8087 38.7 µM 0.738692832990527 0.185996117593482 no 625 0.230046769383236 266 5168703
SGTC_2753 fluvastatin 17.09 µM 0.736489659636139 0.186668080158361 no 626 0.230716379069696 268 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2630 antimycin a 100 µM 0.733310533779847 0.187640351114411 no 627 0.231684525887509 277 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_745 0469-0705 296 µM 0.730137121726574 0.188613988676922 no 628 0.232653186240286 282 3486736
SGTC_381 3461-2219 42.7 µM 0.728122318289211 0.189233765921509 no 629 0.233269356445912 269 2883159
SGTC_2546 rhodinyl acetate 100 µM 0.727617080615799 0.189389379394143 no 630 0.233424010895558 250 6708682
SGTC_1246 0422-0085 105 µM 0.727281746052768 0.189492706090765 no 631 0.233526688997349 272 264295
SGTC_2806 7952793 58.44 µM 0.726722420924248 0.189665128204622 no 632 0.233698007836239 258 2972490
SGTC_588 3970-1144 52.9 µM 0.725858682567525 0.189931580727266 no 633 0.233962703933312 236 1888707
SGTC_2589 lobaric acid 100 µM 0.724976223923936 0.190204045754185 no 634 0.234233308376565 263 73157 A novel microtubule depolymerizer.
SGTC_991 3996-0057 64.7 µM 0.724849922016538 0.1902430619512 no 635 0.234272052810929 253 715343
SGTC_607 4491-0986 66.8 µM 0.724370689928837 0.190391147294665 no 636 0.234419094540338 234 698981 YDR232W HEM1
SGTC_3142 9086498 49.47 µM 0.724318487267971 0.190407282477805 no 637 0.234435114851956 260 25236367
SGTC_361 000s-0510 1.45 µM 0.722081365288544 0.191099537543346 no 638 0.235122227183274 263 660
SGTC_2208 7283366 200 µM 0.72154828164882 0.191264722368406 no 639 0.235286123084202 265 898663
SGTC_3236 9132701 49.47 µM 0.721054033712324 0.191417951471819 no 640 0.235438135327999 264 24282524
SGTC_1172 0370-0043 85 µM 0.720729461221584 0.191518617891624 no 641 0.235537991204579 257 376585
SGTC_2298 7976326 193.81 µM 0.719914506963499 0.191771519530494 no 642 0.235788817728321 237 2235818
SGTC_2796 7949634 45.45 µM 0.71767778651279 0.192466682525887 no 643 0.236477991469358 277 2971588
SGTC_2367 9070478 135.38 µM 0.717193449693941 0.192617414978913 no 644 0.236627370230325 254 572802
SGTC_2744 captopril 92.04 µM 0.716889447102412 0.192712061719315 no 645 0.236721156969413 226 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1689 st020265 53.493 µM 0.716328180262883 0.192886878553871 no 646 0.236894365077196 261 5758320 YPR016C TIF6
SGTC_2190 6049624 200 µM 0.714472363855444 0.193465595857689 no 647 0.237467569614779 268 2265554
SGTC_802 4112-3352 742 µM 0.713654584287266 0.193720947886931 no 648 0.237720398003815 239 704594
SGTC_189 3970-0742 2.116 µM 0.713242217878966 0.193849787376102 no 649 0.237847943029829 264 2891807
SGTC_3018 9082602 49.47 µM 0.71319699749637 0.193863919179751 no 650 0.237861931987631 270 17332089
SGTC_1505 k297-0037 20.6 µM 0.713169648367191 0.193872466349869 no 651 0.237870392679311 263 4089396
SGTC_2469 5655019 90.81 µM 0.712686788107128 0.194023408017733 no 652 0.238019796886817 265 2788239
SGTC_3230 9131665 49.47 µM 0.712355875955886 0.194126892185725 no 653 0.2381222157674 257 15943720
SGTC_744 1594-0068 283 µM 0.710563566320212 0.194687974400677 no 654 0.238677363520251 277 668392
SGTC_1765 st044815 90.4 µM 0.708907646251121 0.195207235777901 no 655 0.239190894912305 279 645695
SGTC_3086 9117350 49.47 µM 0.708359081183187 0.19537943955449 no 656 0.239361148112181 243 2679265
SGTC_1192 1488-0095 21.4 µM 0.706972792331794 0.195815029968897 no 657 0.239791692941815 281 915875
SGTC_2763 lisinopril 49.32 µM 0.705397120710928 0.196310841962765 no 658 0.240281567671561 273 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2686 alizarin 95.37 µM 0.704947501286944 0.196452461844008 no 659 0.240421453834351 249 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1324 1418-0026 34.4 µM 0.704524245369139 0.19658583438103 no 660 0.240553178271109 261 1372513
SGTC_414 piperonyl butoxide 100 µM 0.703547398649401 0.196893858728559 no 661 0.240857339518077 261 5794 A potent inhibitor of cytochrome P450.
SGTC_1155 4088-0394 48.2 µM 0.702913079269552 0.197094031974395 no 662 0.241054959846197 278 2326248
SGTC_1977 st070720 65.3 µM 0.701898137313168 0.197414574994665 no 663 0.241371345321838 249 682188
SGTC_619 1652-1634 108 µM 0.701592470783127 0.19751117355316 no 664 0.241466674216879 268 5400454
SGTC_752 1896-0090 130 µM 0.700856034833714 0.197744023770065 no 665 0.241696432082196 263 772567
SGTC_2890 9046729 58.44 µM 0.70053505800108 0.197845563809274 no 666 0.241796609549712 273 903329
SGTC_968 1309-0633 340 µM 0.69874106559456 0.198413667642343 no 667 0.242356932603678 274 3761976
SGTC_1798 st045719 60.953 µM 0.698416171066717 0.198516657208191 no 668 0.242458483084363 260 3980186
SGTC_2761 levamisole 97.89 µM 0.697984113406109 0.198653666774487 no 669 0.242593564651428 262 26879 An alkaline phosphatase inhibitor.
SGTC_893 0958-0369 48.9 µM 0.697806703516828 0.198709941637626 no 670 0.242649043135962 271 6819948
SGTC_1088 bifonazole 369 nM 0.697437806259167 0.198826987546215 no 671 0.242764424312907 257 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1701 st028638 40.4 µM 0.697250491793111 0.198886435696426 no 672 0.242823022624051 266 3490878
SGTC_2642 cholecalciferol 100 µM 0.696274017868332 0.199196513511133 no 673 0.243128620673232 264 9821465 A vitamin D precursor, similar to steriods.
SGTC_2807 7945238 51.95 µM 0.696268946751659 0.1991981245962 no 674 0.243130208276535 272 17148797
SGTC_1146 3579-1023 7 µM 0.694041150636043 0.199906650457585 no 675 0.243828201347607 284 X1146
SGTC_2408 sulbentine 18.36 µM 0.693796668750369 0.199984497389194 no 676 0.243904866016182 260 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_495 decylubiquinone 155 µM 0.692496056942774 0.200398939248202 no 677 0.244312930636086 284 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_704 1310-0270 142 µM 0.69229113418805 0.200464285200635 no 678 0.244377258322613 289 5718033
SGTC_2200 6600604 21.907 µM 0.68992291696246 0.201220392611911 no 679 0.245121331666079 300 2904777
SGTC_32 0928-0142 34.1 µM 0.689168659839089 0.201461564981424 no 680 0.245358568295526 276 2244242
SGTC_1103 duloxetine 36.1 µM 0.688951588379161 0.201531005279917 no 681 0.245426866682273 273 60835 A selective serotonin reuptake inhibitor.
SGTC_2575 plumbagin 510 nM 0.688618718955252 0.201637516740094 no 682 0.245531619060576 269 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2994 9053520 71.4286 µM 0.687568333815643 0.201973839687463 no 683 0.245862327542346 266 4647384
SGTC_1554 st069299 38.7 µM 0.687132437001307 0.202113508069613 no 684 0.245999637623921 248 24207999
SGTC_3017 9080681 49.47 µM 0.686972985801504 0.202164613243826 no 685 0.246049875973465 286 16451914
SGTC_2052 5265182 7.135 µM 0.686042277713099 0.202463065636456 no 686 0.246343224310155 259 1239884
SGTC_3165 9101544 49.47 µM 0.685447076523657 0.202654068257641 no 687 0.246530923018069 273 5002184
SGTC_3277 9138724 49.47 µM 0.68378670389787 0.203187457890272 no 688 0.247054931877826 254 15943418
SGTC_1109 tnp00067 928.257 nM 0.681863189527319 0.203806427601617 no 689 0.247662731721809 268 676295
SGTC_817 1391-0715 46 µM 0.679708847132339 0.204501008368093 no 690 0.248344416510608 293 1353946
SGTC_2543 pimpinellin 60.67 µM 0.679522526606957 0.204561146018319 no 691 0.248403419680559 270 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2699 st077704 54.6 µM 0.679208725003567 0.204662453817393 no 692 0.248502809887561 273 645852
SGTC_813 k007-0158 173 µM 0.678888817753508 0.204765763483629 no 693 0.248604155740897 281 6523916
SGTC_468 gf-109203x 121 µM 0.678530659239059 0.204881462665308 no 694 0.248717645621531 251 2396 A protein kinase C inhibitor.
SGTC_841 0251-0215 91.2 µM 0.678091064331983 0.205023522102561 no 695 0.248856977999471 280 3888614
SGTC_1613 st002381 52.1 µM 0.677919766835571 0.20507889442997 no 696 0.248911283069015 277 551167
SGTC_1371 2421-0008 32.7 µM 0.676800187265852 0.205441020051796 no 697 0.249266369660324 278 2827552
SGTC_354 2783-3500 4.88 µM 0.676167209857465 0.205645923167481 no 698 0.249467244312455 276 6740761
SGTC_684 1140-0066 328 µM 0.675562232364867 0.205841875671738 no 699 0.249659313594881 279 6813534
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.675379778192782 0.205900994402577 no 700 0.24971725486748 283 1273210
SGTC_1008 4106-0037 6 µM 0.674808183278954 0.206086267561046 no 701 0.249898820294076 294 2905394
SGTC_188 3229-0966 278.469 µM 0.67419158136542 0.206286239798945 no 702 0.250094760596104 279 5722370
SGTC_2946 9065502 71.43 µM 0.673949843595887 0.206364669958718 no 703 0.250171600903966 238 16489101
SGTC_1507 4075-3230 155 µM 0.673277018139283 0.206583056573243 no 704 0.25038553539984 278 659771
SGTC_2115 tiliquinol 12.7705 µM 0.672799514701934 0.206738128309051 no 705 0.250537423272095 288 71208 A bioactive hydroxyquinoline.
SGTC_442 cape 100 µM 0.672360497258156 0.206880762311126 no 706 0.250677112293707 263 5281787
SGTC_1650 st011916 45.8 µM 0.672287428274403 0.206904507616237 no 707 0.250700365794422 293 242528
SGTC_3119 9125183 49.47 µM 0.672104959787259 0.206963811637052 no 708 0.250758439621938 255 22695334
SGTC_427 1354-0053 47.3 µM 0.670814075258571 0.207383648796358 no 709 0.251169489855732 290 6813657
SGTC_890 0929-0006 47.2 µM 0.670076079599187 0.207623894753306 no 710 0.251404646319618 272 1378169
SGTC_1706 st031321 9.9705 µM 0.668757143688471 0.208053668436025 no 711 0.251825204440791 272 6103185
SGTC_249 wiskostatin 11.211 µM 0.668165279131782 0.20824669735976 no 712 0.252014048026291 264 2775510 A n-wasp and actin depolymerizer.
SGTC_1395 3486-0190 4.35 µM 0.667455851396937 0.208478207160402 no 713 0.25224050039212 292 6748079
SGTC_1746 st038117 42 µM 0.666572326333063 0.208766742799866 no 714 0.252522675326014 275 2898218
SGTC_405 ebelactone b 50 µM 0.663383825002479 0.20980997721396 no 715 0.253542381288869 282 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1478 0453-0656 35.7 µM 0.66066442406099 0.210702145050004 no 716 0.254413771792604 299 5258496
SGTC_2671 danthron 100 µM 0.659272414179898 0.211159688744344 no 717 0.254860426667062 285 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1997 st073024 93.8 µM 0.65880871468357 0.211312232637634 no 718 0.255009305226179 279 686268
SGTC_226 1,3-diallylurea 8.28947 mM 0.658196493844027 0.211513734660667 no 719 0.255205938744751 280 74537 YKL182W FAS1
SGTC_2035 5154463 94.595 µM 0.65769770428817 0.211677985854565 no 720 0.255366198912548 295 2769623
SGTC_1024 4507-0395 26 µM 0.656146233683717 0.212189361487125 no 721 0.255865019611423 271 4201836
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.655842000945538 0.212289723366633 no 722 0.255962894529592 244 4000243
SGTC_1788 fluconazole 20 µM 0.653261574184773 0.213142082918596 no 723 0.256793830185633 305 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1991 st073000 8.92 µM 0.652038072956554 0.213546923130646 no 724 0.257188305838373 301 4301969 YIL048W NEO1
SGTC_2045 5106652 78.05 µM 0.65043156081596 0.214079176390326 no 725 0.25770674814266 274 673349
SGTC_2536 dehydroabietamide 32.04 µM 0.649341397138142 0.214440797630311 no 726 0.258058866847179 279 3983547
SGTC_305 1682-2595 20.8 µM 0.649246846201377 0.214472178116092 no 727 0.258089418193102 295 226033
SGTC_2610 ononetin 44.17 µM 0.648946419066769 0.214571904517839 no 728 0.258186504805308 285 259632
SGTC_1512 0259-0544 12.2 µM 0.647451862126721 0.215068421213332 no 729 0.258669769937327 280 18476
SGTC_2954 9074818 52.69 µM 0.646649584285389 0.215335226191576 no 730 0.258929379576616 300 16648742
SGTC_1091 telmisartan 47.6 µM 0.645793603379554 0.215620102278173 no 731 0.259206515572194 303 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_3004 9076122 71.4286 µM 0.645040518032122 0.215870914652237 no 732 0.259450464386649 302 44782551
SGTC_2616 abietic acid 100 µM 0.644297615813553 0.216118501144722 no 733 0.259691230693746 298 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_386 1509-0011 3.07 µM 0.643833758908146 0.2162731737685 no 734 0.259841619994123 280 3107280
SGTC_3283 9109332 35.8195 µM 0.643627278758479 0.216342044976805 no 735 0.259908578375678 267 17027281
SGTC_2359 9039622 200 µM 0.642353033697553 0.216767348722111 no 736 0.260321993581848 297 6463596
SGTC_478 N-arachidonylglycine 10 µM 0.641645261316292 0.217003790040068 no 737 0.260551769036617 259 5283389
SGTC_2273 7815444 169.05 µM 0.641062201995748 0.217198681123738 no 738 0.260741135308395 334 2824616
SGTC_2239 6685329 187.64 µM 0.640530469512716 0.217376504019179 no 739 0.260913893347792 265 805680
SGTC_2160 5660466 132.927 µM 0.640471586518809 0.21739620094022 no 740 0.260933027848091 293 2859134
SGTC_2989 9073649 71.4286 µM 0.63967624057438 0.217662352662521 no 741 0.261191552567072 313 21367202
SGTC_2289 7946404 165.07 µM 0.638661684731664 0.21800213273149 no 742 0.261521521716115 289 1246120 YPR165W RHO1
SGTC_586 0957-0265 8.15 µM 0.637693855028503 0.218326548784056 no 743 0.261836493215311 291 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_3246 9135460 32.98 µM 0.637217042329462 0.218486478377995 no 744 0.2619917391424 294 41446951
SGTC_1325 1431-0015 227 µM 0.636154099554806 0.218843246857988 no 745 0.262337993528119 273 1103340
SGTC_131 0141-0277 33.849 µM 0.635962479144532 0.218907598399905 no 746 0.262400438940766 308 1547771
SGTC_3002 9075603 71.4286 µM 0.635070212138505 0.219207390164094 no 747 0.262691311827424 294 20105405
SGTC_2741 miltefosine 3.04 µM 0.635012984302322 0.219226626129597 no 748 0.262709973334879 277 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_284 0988-0104 32.6 µM 0.634625278580786 0.219356971021945 no 749 0.262836418710349 298 4666532
SGTC_3020 9089140 49.47 µM 0.634492646152776 0.219401571659625 no 750 0.262879682262593 284 17217859
SGTC_928 2764-0428 58.7 µM 0.634419508243077 0.219426168155777 no 751 0.262903540774393 295 662578
SGTC_221 trifluoperazine 10.304 µM 0.633814944580613 0.219629545374363 no 752 0.263100799482839 304 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1815 st051655 58.2 µM 0.633669740997885 0.219678408457597 no 753 0.263148188171495 296 5984156
SGTC_3152 9099253 49.47 µM 0.632859348902667 0.219951231601731 no 754 0.263412748062628 291 25236131
SGTC_1245 0418-0076 17.2 µM 0.6300412804881 0.220901462643393 no 755 0.264333788082315 317 6790114
SGTC_2157 5649910 96.377 µM 0.629518281936415 0.22107807193659 no 756 0.26450490188849 296 2858091
SGTC_1207 2099-0101 141 µM 0.628809343643481 0.221317599424243 no 757 0.264736941104355 292 5837381
SGTC_2252 omeprazole 400 µM 0.627529313576174 0.221750456182442 no 758 0.265156163652252 278 4594 A proton pump inhibitor.
SGTC_2003 4023581 200 µM 0.62604961428671 0.222251435537134 no 759 0.26564119962494 303 16641307
SGTC_1431 4049-0260 9.09 µM 0.620738975002961 0.224054758748146 no 760 0.267385690490475 311 3854841
SGTC_2037 5169046 200 µM 0.618316137041533 0.224880230098718 no 761 0.268183483329193 278 5718022
SGTC_1583 clindamycin 39.6 µM 0.618247218685463 0.224903736070901 no 762 0.268206194295583 315 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_440 fluspirilene 35.1 µM 0.615944245460008 0.225690011220071 no 763 0.268965659139496 301 3396 An atypical antipsychotic.
SGTC_897 1000-0139 31.4 µM 0.613850739040333 0.226406118203708 no 764 0.269656982408507 295 6151020
SGTC_2679 rapamycin 1 nM 0.613384697461278 0.226565707316216 no 765 0.269811000945409 273 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1923 st058458 19.1 µM 0.612457778824195 0.226883305703112 no 766 0.27011746210162 342 3534982
SGTC_1332 1480-0653 17.5 µM 0.611723966828855 0.227134916240371 no 767 0.270360201077612 299 5749438
SGTC_298 1391-0729 10 µM 0.611163560943752 0.227327174918756 no 768 0.270545652140705 300 3237558
SGTC_1274 0865-0114 173 µM 0.611080008803692 0.227355847038296 no 769 0.270573306888328 285 870624
SGTC_1104 tacrolimus 29.8 µM 0.610712930954192 0.227481839222168 no 770 0.270694821943302 297 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1596 piperlongumine 63 µM 0.610662229438246 0.227499244601223 no 771 0.270711607983777 280 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1061 3448-9325 110 µM 0.610561567879207 0.227533803040952 no 772 0.270744936121289 307 723482
SGTC_2676 harmalol 100 µM 0.607461088834747 0.22859968513573 no 773 0.271772479049507 288 5459187 A monoamine oxidase inhibitor
SGTC_1262 0737-0114 49.6 µM 0.607452329568063 0.228602700361883 no 774 0.271775384742256 299 765919
SGTC_886 0866-0150 153 µM 0.60708720669142 0.228728407470466 no 775 0.271896519923567 303 271463
SGTC_61 0978-8327 98.565 µM 0.604158148938595 0.229738247690502 no 776 0.272869251226377 314 6150059 YHR072W ERG7
SGTC_1482 3346-2049 8.48 µM 0.603760753261677 0.229875448398309 no 777 0.273001357989204 277 3826804
SGTC_2933 9026794 32.47 µM 0.603543131267171 0.22995060174327 no 778 0.273073715786518 299 17586027
SGTC_1445 4239-0156 97.7 µM 0.602261070288586 0.230393626343312 no 779 0.273500184988469 323 4008346
SGTC_788 1182-0090 188 µM 0.600912647503194 0.230860097144309 no 780 0.273949084440623 293 5715185
SGTC_2176 5809774 33.9695 µM 0.600347800753077 0.231055655772408 no 781 0.27413723407633 290 2870539
SGTC_3095 9117207 49.47 µM 0.599964855208303 0.231188289979994 no 782 0.274264828982804 295 17015229
SGTC_712 r015-0009 80.6 µM 0.599495791271481 0.231350809390359 no 783 0.274421157913203 316 6813872 YLR060W FRS1
SGTC_78 0336-0123 156.75 µM 0.599420045021252 0.231377059624558 no 784 0.274446406634432 295 6765896
SGTC_3136 9095672 49.47 µM 0.598795651503382 0.231593509527367 no 785 0.274654581235684 294 17217380
SGTC_2020 4017018 200 µM 0.597805559647318 0.231936962289296 no 786 0.274984840288812 316 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_766 1391-0721 126 µM 0.597758304874796 0.231953361576496 no 787 0.275000607672804 323 1020919 YIL115C NUP159
SGTC_1175 0741-0056 27.6 µM 0.597129924159648 0.23217149607071 no 788 0.275210320255268 318 765927
SGTC_1912 st060209 90.8 µM 0.596687203676798 0.232325249469636 no 789 0.275358118798391 325 688787
SGTC_3034 9090421 49.47 µM 0.595745549621359 0.232652466937326 no 790 0.275672611988068 291 17173761
SGTC_2812 7970281 58.44 µM 0.595529926460214 0.232727430340671 no 791 0.275744650550702 322 2233435
SGTC_465 cgp-37157 41 µM 0.594497390319069 0.233086587147144 no 792 0.276089743617338 291 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3075 9116269 49.47 µM 0.593934474510363 0.233282521024577 no 793 0.276277969971023 319 17015205 YNL244C SUI1
SGTC_867 0518-0118 155 µM 0.5936098019925 0.233395571205766 no 794 0.276386561763058 312 6848158
SGTC_2214 7179297 48.276 µM 0.592138668205955 0.233908197100384 no 795 0.276878867600825 305 769744
SGTC_3108 9121785 49.47 µM 0.591934247008978 0.233979478294378 no 796 0.276947309858659 293 17140271
SGTC_3205 9113483 49.47 µM 0.589540989831835 0.234814895984387 no 797 0.277749211851733 325 17018033
SGTC_1020 4335-0961 93.3 µM 0.58728065973835 0.235605424238806 no 798 0.278507614026814 339 669075
SGTC_3101 9120531 49.47 µM 0.586016263883964 0.236048273776166 no 799 0.27893229274076 337 24824904
SGTC_215 1287-0124 461.5 µM 0.584098747035942 0.236720750604798 no 800 0.279576938878985 322 5560863
SGTC_1690 st023502 41.2 µM 0.581686321116648 0.237568287671942 no 801 0.280388993478973 319 24207482
SGTC_3 0833-0587 95.581 µM 0.581188557423161 0.237743369775524 no 802 0.2805566893698 314 5382644
SGTC_3039 9090270 49.47 µM 0.580971495798452 0.237819740621874 no 803 0.280629832321217 281 17173750
SGTC_1687 st020778 55.3625 µM 0.579395776855079 0.238374543882477 no 804 0.281161076515264 295 4259299
SGTC_312 4092-0653 6.84 µM 0.57678867700855 0.239294045999401 no 805 0.282041109755198 309 1148278
SGTC_1774 st048371 48.465 µM 0.576545749650628 0.23937982300512 no 806 0.282123178019116 308 4242727
SGTC_1217 1183-1422 255 µM 0.57477136022784 0.240006864224774 no 807 0.282722969251544 315 2849664
SGTC_2682 pyrogallin 40.03 µM 0.573035431542715 0.240621179699141 no 808 0.283310351996512 300 822798 An ATP competetive kinase inhibitor.
SGTC_2415 st077333 57.7 µM 0.572636008342794 0.240762649776277 no 809 0.283445586804707 331 2766255
SGTC_1182 1222-0449 220 µM 0.572558055757561 0.240790264762832 no 810 0.283471983228703 311 658318
SGTC_643 k048-0106 28.4 µM 0.571218022182493 0.241265245883475 no 811 0.283925931567577 318 6763920
SGTC_2435 5706476 10.6 µM 0.569645934838831 0.241823127984308 no 812 0.284458933265545 291 5725375
SGTC_1800 st050079 29.0735 µM 0.568702300718162 0.242158328589815 no 813 0.284779093102162 323 3645560
SGTC_2932 9016711 44.54 µM 0.56823527712868 0.242324319279827 no 814 0.284937610261435 327 7117328
SGTC_2847 9005661 71.43 µM 0.568097555398426 0.242373280450498 no 815 0.284984363808688 304 2991449
SGTC_975 1335-0046 28.5 µM 0.567865825021172 0.242455674538501 no 816 0.285063039512907 324 16486740
SGTC_2953 9074162 66.49 µM 0.56716871413416 0.242703630843772 no 817 0.285299780820865 306 16451992
SGTC_2770 toltrazuril 17.5 µM 0.566971999294045 0.242773625434816 no 818 0.285366602812265 297 68591 Kills coccidiodes.
SGTC_534 k292-0788 63.4 µM 0.566788929385995 0.242838774733558 no 819 0.285428796457415 348 4146317
SGTC_3114 9122766 49.47 µM 0.566782674374874 0.242841000878698 no 820 0.285430921562634 280 17176985
SGTC_1052 3253-3998 198 µM 0.564795184144978 0.243548903340474 no 821 0.286106541523169 295 5450317
SGTC_332 4112-0506 40.9 µM 0.563004843944221 0.244187538080117 no 822 0.286715792746148 319 2790355
SGTC_2868 9035608 32.47 µM 0.562997378460512 0.244190202992254 no 823 0.286718334531089 320 6462614
SGTC_2798 7813637 45.45 µM 0.562639522712062 0.244317963154814 no 824 0.286840186766671 322 956368
SGTC_2327 6189656 200 µM 0.561430502008977 0.244749869021365 no 825 0.287252047687755 344 5349088
SGTC_655 k060-0012 42 µM 0.560973241230286 0.244913326153591 no 826 0.28740788951272 337 5994525
SGTC_942 3253-1115 227 µM 0.560548040511515 0.245065375462188 no 827 0.287552840628112 354 46497897
SGTC_10 0279-0212 42.575 µM 0.559897247986734 0.245298193387087 no 828 0.287774762998593 301 39851 YBR002C RER2
SGTC_158 k038-0087 26.446 µM 0.559151010249664 0.245565302646463 no 829 0.288029332033742 321 X158
SGTC_730 1436-0052 41.2 µM 0.558181181840948 0.245912677566804 no 830 0.288360334787224 292 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2641 levomentholum 100 µM 0.557474917095124 0.246165814621738 no 831 0.288601495977052 321 16666
SGTC_3021 9087658 49.47 µM 0.552200107310687 0.24806080554148 no 832 0.290405630432637 321 25237042
SGTC_3049 9092223 49.47 µM 0.551352529515268 0.248366024447397 no 833 0.290696017724804 321 8623917
SGTC_2281 7943571 200 µM 0.551152282732117 0.248438163988331 no 834 0.290764643787116 326 1244024
SGTC_2505 galangin 7.89 µM 0.548903942469593 0.249248901711129 no 835 0.291535686228668 350 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1871 st057448 67.3 µM 0.547806093204249 0.249645290019004 no 836 0.291912527154279 354 691747
SGTC_933 2914-0560 114 µM 0.546825349516234 0.249999679274407 no 837 0.292249362875876 297 463887
SGTC_428 3448-4153 16.5 µM 0.545693508537176 0.250408998728626 no 838 0.29263831743355 297 3834874
SGTC_1090 efavirenz 20.7 µM 0.545301283857305 0.250550925858724 no 839 0.292773160630082 325 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2395 5646831 180.19 µM 0.544693435462289 0.25077096095245 no 840 0.292982190235683 337 6808628
SGTC_3038 9091290 49.47 µM 0.544688348683357 0.250772802747604 no 841 0.292983939791943 343 25236843
SGTC_2943 9068529 45.32 µM 0.542319142518196 0.251631410887286 no 842 0.293799335370438 337 3270634
SGTC_276 colchicine 750 µM 0.541976813807615 0.25175560021037 no 843 0.293917239362388 343 2833 A microtubule depolymerizer.
SGTC_2972 9093619 59.92 µM 0.539615735315342 0.252613028156108 no 844 0.294731031341187 288 25236256
SGTC_1851 st056236 18.9 µM 0.539380207150461 0.252698644735621 no 845 0.294812267701747 311 5393171
SGTC_449 xestospongin c 11.1929 µM 0.538992526098028 0.252839603511985 no 846 0.29494600580914 343 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2123 5259487 200 µM 0.538411417116498 0.253050969154431 no 847 0.295146522976284 316 2173474
SGTC_1434 4073-0095 163 µM 0.53812763737563 0.253154221581346 no 848 0.295244466673891 325 24133745
SGTC_2745 rifampicin 24.3 µM 0.53749925842497 0.253382934253107 no 849 0.295461398515846 308 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1987 st072290 61.9 µM 0.537144085611771 0.253512255423614 no 850 0.295584045311229 331 54697379
SGTC_153 4077-0274 519.67 µM 0.536572456395964 0.253720462844363 no 851 0.295781487062903 313 3121976
SGTC_1703 st026983 48.3 µM 0.536377993769411 0.253791313420907 no 852 0.295848668610824 322 1104023
SGTC_404 fumagillin 50 µM 0.535417888097067 0.254141270815602 no 853 0.29618046168088 324 12015870 A methionine aminopeptidase binder.
SGTC_2738 aclarubicin 5.55 µM 0.534433470754058 0.254500352399957 no 854 0.296520833509257 288 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_736 0958-0254 92.6 µM 0.534106597920858 0.254619643126029 no 855 0.296633892580307 350 6812352
SGTC_367 0335-0881 7.1 µM 0.533799201429122 0.25473185276634 no 856 0.296740233167807 348 23828853
SGTC_2151 5563267 85.4165 µM 0.533501605346911 0.254840509602727 no 857 0.296843200031618 359 5310824
SGTC_910 3454-3003 490 µM 0.533134238107291 0.254974674396305 no 858 0.29697032993953 333 820824
SGTC_1238 0333-0287 48.8 µM 0.532828534123913 0.255086347553103 no 859 0.297076139845495 323 7226
SGTC_5 0352-0601 109.883 µM 0.532344470616635 0.255263227460669 no 860 0.29724371859382 318 762456
SGTC_671 0560-0003 407 µM 0.531340501561987 0.255630288496437 no 861 0.297591421952747 347 3238678
SGTC_2588 indole-3-carbinol 100 µM 0.530829111229039 0.255817363780713 no 862 0.297768602469717 348 3712 Induces cell cycle arrest.
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.530699071008772 0.255864946099397 no 863 0.297813664950805 324 97141
SGTC_2646 retinol 96.75 µM 0.530308498380484 0.256007886197987 no 864 0.29794902770859 338 445354 A vitamin A analog and teratogen.
SGTC_3146 9095609 49.47 µM 0.530215995348697 0.25604174616219 no 865 0.297981091065903 325 17173999
SGTC_1093 fluphenazine 7.97 µM 0.527647230974104 0.25698295330765 no 866 0.298872102461671 340 6602611 An atypical antipsychotic.
SGTC_1804 st050076 49.1 µM 0.526436387448326 0.257427235336632 no 867 0.299292519603324 321 3895976
SGTC_3190 9110366 49.47 µM 0.525912795693897 0.257619474848925 no 868 0.299474399014986 346 17123768
SGTC_3249 9135183 49.47 µM 0.525902738873011 0.257623167994019 no 869 0.299477892930659 313 4902779
SGTC_3173 9105693 49.47 µM 0.525571092820668 0.257744973073533 no 870 0.299593122927539 334 17096658
SGTC_2944 9067346 25.62 µM 0.523576534974153 0.25847815297717 no 871 0.30028655284439 332 6473075
SGTC_2048 5246248 200 µM 0.523350948468263 0.258561144312868 no 872 0.300365026111806 309 677046
SGTC_3131 9127911 49.47 µM 0.522821886326473 0.258755835842217 no 873 0.300549103757038 304 45595681
SGTC_3322 9139058 2.11 µM 0.522627637791908 0.258827337115139 no 874 0.300616701819604 300 4908926 YPR165W RHO1
SGTC_2032 5185112 25.99 µM 0.522614601806894 0.25883213591905 no 875 0.30062123855946 304 5718189
SGTC_1432 4049-0298 68.4 µM 0.522602851836052 0.258836461355158 no 876 0.300625327771455 347 741646
SGTC_2167 5876490 200 µM 0.521748710964351 0.259150990523447 no 877 0.300922652173853 340 686534
SGTC_2372 9071633 200 µM 0.521445728089308 0.259262608511973 no 878 0.301028151642903 314 21321366
SGTC_466 geldanamycin 89.2 µM 0.520347482470843 0.25966740707221 no 879 0.301410703449725 315 5288382 HSP90 inhibitor.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.519778130063119 0.259877391043328 no 880 0.301609112018609 326 756377
SGTC_163 TUB2.036 7.546 µM 0.519662134348238 0.259920182387728 no 881 0.301649541538488 326 15992207 YJR013W GPI14
SGTC_873 0591-4978 488 µM 0.519350901198479 0.260035015661282 no 882 0.301758031783568 340 3305145
SGTC_3180 9109287 49.47 µM 0.517492038786526 0.260721409954898 no 883 0.302406362495681 320 18891271
SGTC_2768 sulfasalazine 50.2 µM 0.517214397147954 0.260824010496044 no 884 0.30250325144794 335 5384001 An antioxidant and salicylic acid derivative.
SGTC_637 1181-0519 7.26 µM 0.516595441153515 0.261052816133661 no 885 0.302719299379008 332 6252091 YGR060W ERG25
SGTC_660 4031-1742 102 µM 0.515730785411424 0.261372620749029 no 886 0.303021225002096 330 6738706
SGTC_105 0111-0055 734.78 µM 0.515244257167164 0.261552658222891 no 887 0.303191173038689 324 5179370
SGTC_2583 asiatic acid 100 µM 0.514684420893033 0.261759901728337 no 888 0.303386780850663 349 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2565 isoliquiritigenin 100 µM 0.514279783275174 0.261909745308821 no 889 0.303528197068402 296 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2568 diosmetin 100 µM 0.513268155416184 0.262284559137137 no 890 0.303881878162708 343 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1607 st000305 50.6 µM 0.511716215771311 0.262860095112104 no 891 0.304424817764969 348 5457690
SGTC_2425 5628681 7.85 µM 0.511461589332239 0.262954584820494 no 892 0.304513938978103 343 5714958
SGTC_2986 9022445 71.43 µM 0.509994397763083 0.263499385222317 no 893 0.305027693318417 364 6459286
SGTC_1916 st067606 49.2 µM 0.506017152729399 0.264979115418698 no 894 0.306422304175646 346 19590279
SGTC_1500 4488-1866 171 µM 0.505339596971334 0.265231619660931 no 895 0.30666016791649 383 2900003
SGTC_2245 6637752 200 µM 0.504192028753846 0.265659561632856 no 896 0.307063220708917 356 681890
SGTC_2809 7964133 12.99 µM 0.503658371379985 0.265858688077714 no 897 0.30725073314432 359 1253665
SGTC_2787 5284540 71.43 µM 0.503192153181129 0.266032712464927 no 898 0.30741459057508 350 736958
SGTC_2840 9008771 71.43 µM 0.500260904553176 0.267128174250408 no 899 0.308445689271376 301 2992978
SGTC_500 h-89 112 µM 0.499591854847993 0.267378529315092 no 900 0.30868124714128 358 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2188 6126565 140.678 µM 0.499558175459647 0.267391135102696 no 901 0.308693107004936 334 874518
SGTC_1309 pyrazolanthrone 13.4 µM 0.498758235664617 0.267690630984062 no 902 0.30897485652748 370 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_487 nimodipine 119 µM 0.498486686498829 0.267792336877737 no 903 0.309070525353414 344 4497 L-type voltage-gated calcium channels inhibitor
SGTC_702 1488-0190 94 µM 0.498030215281746 0.267963347245148 no 904 0.309231372797752 316 949357
SGTC_3295 9122362 53.5725 µM 0.497123233601739 0.268303297971561 no 905 0.30955107578314 351 4730473
SGTC_2324 6149169 200 µM 0.495929783454219 0.268750951802996 no 906 0.309971976008063 349 2888231
SGTC_3313 9133968 57.047 µM 0.495627930914343 0.26886423375312 no 907 0.310078471403182 325 1494643
SGTC_3155 9099265 49.47 µM 0.495317720808618 0.26898067718409 no 908 0.310187931999278 364 25236499
SGTC_1143 3454-2408 5.08 µM 0.494902809612838 0.269136461781258 no 909 0.310334363666644 320 X1143
SGTC_1234 0326-0494 15.5 µM 0.494067438327567 0.269450251656661 no 910 0.310629276536106 368 1547813
SGTC_2385 9074692 200 µM 0.492221096527999 0.270144441567104 no 911 0.311281526115938 329 17046906
SGTC_2748 diazoxide 86.69 µM 0.491653425603935 0.270358054854771 no 912 0.311482184165631 327 3019 A potassium channel activatior.
SGTC_1510 1123-0200 71.5 µM 0.49139146856905 0.270456657158756 no 913 0.311574798581453 345 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1362 1611-0397 101 µM 0.49031450243236 0.270862222816383 no 914 0.311955683141736 329 27816
SGTC_467 ro 31-8220 72.8 µM 0.489753931664592 0.271073443512141 no 915 0.312154016686464 353 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2915 7971052 15.16 µM 0.487138431981251 0.272060037277777 no 916 0.313080116348492 326 5741558
SGTC_2606 farnesol 9.78 µM 0.487072913957999 0.272084774263487 no 917 0.313103330237584 342 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2862 9027634 71.43 µM 0.486518257346233 0.272294235216288 no 918 0.313299881974851 318 5012562
SGTC_716 1683-5115 658 µM 0.486099490353747 0.272452431770658 no 919 0.313448314126444 363 723597
SGTC_1969 st069479 40.1 µM 0.484588670945764 0.273023549330541 no 920 0.313984075783605 352 3895485
SGTC_3333 9141820 12.094 µM 0.483804967397638 0.273320037298957 no 921 0.314262144701429 359 1939433
SGTC_1633 st005664 67.9 µM 0.483792756913701 0.273324657987567 no 922 0.31426647798558 339 2063822
SGTC_734 2023-0417 80 µM 0.483685697923854 0.273365172883226 no 923 0.314304472418082 366 3935732
SGTC_1173 0443-0020 122 µM 0.483404995935633 0.273471414529409 no 924 0.314404100789681 355 5331295
SGTC_1587 estradiol valerate 56.1 µM 0.482648552689027 0.273757819087481 no 925 0.31467264928828 369 13791 A steroid.
SGTC_1277 0873-0036 22 µM 0.48206113881481 0.273980328024591 no 926 0.314881257518293 335 5965735
SGTC_810 3825-7150 143 µM 0.481962792970235 0.274017589588269 no 927 0.314916188843303 319 22330411 YGL099W LSG1
SGTC_2297 7971671 152.32 µM 0.48142143547947 0.274222745534542 no 928 0.315108502500016 355 909016
SGTC_567 1080-0542 68.4 µM 0.481045327526915 0.274365322210262 no 929 0.315242141868044 325 5950415
SGTC_3111 9122088 49.47 µM 0.480601558505692 0.274533595191648 no 930 0.315399853787373 342 16876704
SGTC_2276 7947513 42.08 µM 0.480391714833208 0.274613183639319 no 931 0.315474442246602 335 2105100
SGTC_3009 9080819 71.4286 µM 0.478650015404627 0.275274205503157 no 932 0.316093815346977 335 17027216
SGTC_2910 7948405 25.97 µM 0.478096165388581 0.275484570512381 no 933 0.316290880612524 358 2971328
SGTC_969 1313-0238 134 µM 0.477788673460637 0.27560139716716 no 934 0.316400311788519 356 5212874
SGTC_601 0986-0029 62.9 µM 0.476962920994344 0.275915249149512 no 935 0.316694262665996 349 24747981
SGTC_2091 4-phenylthiadiazole 200 µM 0.475984228857868 0.276287457648528 no 936 0.31704280685779 341 270010
SGTC_3302 9125395 16.351 µM 0.475600490236333 0.276433465308185 no 937 0.317179513034221 354 17599668
SGTC_2248 tofa 1.1 µM 0.473284034054503 0.277315650183465 no 938 0.31800527565856 349 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2754 granisetron 64.02 µM 0.471628429898417 0.277947002749323 no 939 0.318596015194483 371 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2685 mycophenolic acid 18.85 µM 0.470340085184286 0.27843878845033 no 940 0.319056031453066 340 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_959 1222-0044 107 µM 0.470077981452517 0.278538890311958 no 941 0.319149652343337 368 6083612
SGTC_925 2064-1272 59.6 µM 0.46821573355105 0.279250618678989 no 942 0.319815160938651 363 6815817
SGTC_245 methotrexate 289.6 µM 0.467638084474903 0.279471568547695 no 943 0.320021712528183 338 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2678 equilin 100 µM 0.465434999758425 0.280315023506271 no 944 0.320809987467786 332 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2843 9000894 45.46 µM 0.464799066735456 0.280558720703376 no 945 0.321037678087015 308 2242070
SGTC_2077 5212015 200 µM 0.464530612718239 0.280661626283669 no 946 0.321133816061999 344 780900
SGTC_3128 9127691 49.47 µM 0.463686068503625 0.280985481616757 no 947 0.321436339954677 373 41316314
SGTC_117 lucigenin 22.078 µM 0.462755765478297 0.281342431565866 no 948 0.321769720626688 362 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_446 go6976 132 µM 0.4626544226899 0.28138132921234 no 949 0.321806046206799 378 3501 A protein kinase C inhibitor.
SGTC_2424 5537928 59.2 µM 0.461913050034658 0.281665963663905 no 950 0.322071837590632 347 5382802
SGTC_1874 staurosporine 7.6 µM 0.461307619468255 0.28189850893679 no 951 0.322288959564919 353 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1939 st074455 53.6 µM 0.461215888790952 0.281933750665512 no 952 0.322321861686017 378 1644229
SGTC_1156 4092-0367 4.88 µM 0.459412987424276 0.282626832281193 no 953 0.322968811798535 345 1357585
SGTC_107 0358-0022 2.6945 µM 0.458971310692398 0.282796748967193 no 954 0.323127384152992 379 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1835 st008666 49.2 µM 0.458788048598898 0.282867265809836 no 955 0.323193189001334 339 690455
SGTC_816 0325-0417 81.3 µM 0.45612071324468 0.283894576116333 no 956 0.324151588050701 363 68101
SGTC_916 4466-0038 42 nM 0.454986479015647 0.284331960988247 no 957 0.324559483095828 360 5722064 YGL116W CDC20
SGTC_2827 7993847 71.43 µM 0.453535285864808 0.284892041154406 no 958 0.325081670367843 362 2985692
SGTC_2531 methyl deoxycholate 70.07 µM 0.451688812049914 0.285605437681358 no 959 0.325746589597195 364 16667744 Haematoxylin.
SGTC_1486 3970-0793 4.53 µM 0.450483187815697 0.286071696319814 no 960 0.326181036996623 378 2844330
SGTC_1668 st014914 51.6 µM 0.450442979265386 0.286087252655381 no 961 0.326195530241049 357 2839556
SGTC_1568 digitonin 820 nM 0.450358803130531 0.286119820965306 no 962 0.32622587253054 381 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2228 7354201 200 µM 0.449964761575097 0.286272301696733 no 963 0.326367924790939 387 753451
SGTC_3254 9136651 49.47 µM 0.449166763782508 0.286581217944362 no 964 0.326655680701903 368 16454030
SGTC_1326 1431-2094 10.8 µM 0.447965970203362 0.287046359901012 no 965 0.327088878078468 383 616278
SGTC_340 k038-0059 454 µM 0.447756502486039 0.287127536371762 no 966 0.327164469382867 371 23733424
SGTC_3118 9124250 49.47 µM 0.444548892814942 0.28837195896738 no 967 0.328322894028059 380 1504786
SGTC_2090 5301565 104.445 µM 0.444217842116502 0.288500537846772 no 968 0.328442546886684 358 2056344
SGTC_2102 5377816 72.7585 µM 0.443998342636557 0.288585805533714 no 969 0.32852189108503 384 1379702
SGTC_8 0354-0001 70 µM 0.443459743953506 0.288795082125751 no 970 0.32871661533604 364 4993152
SGTC_1122 capsaicin 818.572 nM 0.443391743117507 0.288821509443722 no 971 0.328741203575818 384 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1855 st056195 39.6 µM 0.442826907026544 0.289041066951941 no 972 0.328945469787775 349 4028379
SGTC_2866 9034245 58.44 µM 0.441835703270342 0.28942654754166 no 973 0.329304050244894 385 6462273
SGTC_3157 9099274 49.47 µM 0.441595145968945 0.28952013703206 no 974 0.329391098578867 366 17217662
SGTC_2065 5221596 34.26 µM 0.440858456405494 0.289806836532871 no 975 0.329657735394273 331 788581
SGTC_2413 inermin 26.06 µM 0.438260196365958 0.290819070316173 no 976 0.330598838142012 396 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2376 9072922 81.32 µM 0.438088466441434 0.290886031292649 no 977 0.330661077410701 349 17087968
SGTC_837 0091-0265 12.5 µM 0.437669910732091 0.291049264820973 no 978 0.330812792199201 369 759367
SGTC_46 0329-0187a 2.197 µM 0.436922183317933 0.291340979248799 no 979 0.331083891729402 376 46494817
SGTC_2825 7998094 58.44 µM 0.435583367789586 0.291863638257062 no 980 0.331569520134174 371 2987815
SGTC_3149 9097855 49.47 µM 0.434965670495039 0.292104927708556 no 981 0.331793672947859 351 25236625 YMR079W SEC14
SGTC_3253 9135987 49.47 µM 0.434019557982608 0.292474685019839 no 982 0.332137119333707 358 4182430
SGTC_2595 hexamethylquercetagetin 100 µM 0.434016033379026 0.292476062903203 no 983 0.332138399056791 394 386331
SGTC_649 1123-0311 367 µM 0.433478553966693 0.292686216571043 no 984 0.332333571512558 365 693629 YIL048W NEO1
SGTC_301 4119-0100 24.5 µM 0.433387899965737 0.292721669064696 no 985 0.332366494771211 384 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3071 9117417 49.47 µM 0.42774178219268 0.294933642550513 no 986 0.334419563331694 371 45595590 YGL055W OLE1
SGTC_202 3594-0513 34.79 µM 0.427118357458807 0.29517835243881 no 987 0.334646561344567 354 708429
SGTC_1988 st071872 53.4 µM 0.426635717737676 0.295367864842928 no 988 0.33482233900661 351 16414116
SGTC_1205 4161-2785 76 µM 0.426199708246244 0.295539115622482 no 989 0.33498116503463 342 3498106
SGTC_2605 digitonin 300 nM 0.425027051149924 0.295999924714637 no 990 0.335408477502636 356 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3096 9117468 49.47 µM 0.424238677981958 0.296309910310597 no 991 0.335695877927488 358 41316311
SGTC_1876 myriocin 605 nM 0.420196651011319 0.29790155424814 no 992 0.337170900540975 391 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2879 9041815 71.43 µM 0.41869164893548 0.298495178791168 no 993 0.337720749845014 359 4942971
SGTC_3271 9137798 49.47 µM 0.418156725733729 0.298706300445543 no 994 0.337916266436967 357 6498326
SGTC_426 0988-0037 14.6 µM 0.418142496318988 0.298711917388935 no 995 0.337921467942977 394 5383008
SGTC_2750 bromebric acid 70.15 µM 0.417567796519962 0.298938815484957 no 996 0.338131573027816 362 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1739 st037196 92.5 µM 0.417215142886531 0.299078085945174 no 997 0.338260524997867 383 612214
SGTC_1657 st012939 43.4 µM 0.416865328951499 0.299216264042385 no 998 0.338388457344509 364 24207257
SGTC_2044 5102272 200 µM 0.415916308226922 0.299591277366089 no 999 0.338735622776494 351 592666
SGTC_2361 9034121 116 µM 0.415911961093577 0.29959299566143 no 1000 0.338737213335944 384 6496917
SGTC_1854 st056233 32.9 µM 0.415712519760402 0.299671833820034 no 1001 0.33881018941327 371 5393174
SGTC_2828 7998861 71.43 µM 0.41550221270698 0.299754977322158 no 1002 0.33888714783864 341 2988188
SGTC_1768 st044301 37.178 µM 0.414240907280865 0.300253845135644 no 1003 0.339348842941343 412 3931349
SGTC_2779 methotrexate 400 µM 0.413930041446612 0.300376855501654 no 1004 0.339462671049967 390 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2652 actinonin 100 µM 0.413895369844147 0.300390576550377 no 1005 0.339475367476543 365 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_398 bronopol 33.3 µM 0.413279132329498 0.300634495548013 no 1006 0.339701058454969 378 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_3344 9148862 3.898 µM 0.412607547372067 0.300900423925556 no 1007 0.339947085354364 377 4905352
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.412163801363185 0.301076192797922 no 1008 0.340109683669404 404 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_561 1550-0330 72.9 µM 0.411884087207419 0.30118701202652 no 1009 0.340212192383263 382 6812934
SGTC_339 3091-4833 71.4 µM 0.411794611204271 0.301222465171854 no 1010 0.340244985745032 358 3240077
SGTC_1567 st069303 68.4 µM 0.411235933800215 0.301443872846343 no 1011 0.340449770869911 391 5581319
SGTC_489 paxilline 115 µM 0.4091059133088 0.302288685674023 no 1012 0.341230968445329 365 105008 A toxic potassium channel blocker.
SGTC_536 3852-0578 10.6 µM 0.407504499235955 0.302924540281256 no 1013 0.341818745149203 367 2869208
SGTC_2743 auranofin 4.32 µM 0.40379667690405 0.304399054075352 no 1014 0.34318112017638 337 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_982 1491-0518 27.5 µM 0.40056785747881 0.30568567584488 no 1015 0.344369157196355 362 3091256
SGTC_2177 5811945 192 µM 0.398648905603242 0.306451480352243 no 1016 0.345075960437707 400 5343475
SGTC_180 1486-1293 102.781 µM 0.398445445509271 0.306532725725483 no 1017 0.345150932191537 362 4140536
SGTC_3125 9127534 49.47 µM 0.397608115443577 0.306867187150614 no 1018 0.345459538727684 358 1639235
SGTC_1974 st069448 26.9 µM 0.397549167897006 0.306890739101875 no 1019 0.345481268321153 356 6323587 YNR016C ACC1
SGTC_993 3909-8757 62.7 µM 0.396907149756004 0.307147303155438 no 1020 0.345717965810023 351 4288324 YLR208W SEC13
SGTC_2863 9028737 58.44 µM 0.39653949894773 0.307294266743007 no 1021 0.345853537470636 405 6460917
SGTC_2823 7987624 58.44 µM 0.395575926705277 0.307679588923034 no 1022 0.34620894959949 391 2239440
SGTC_2342 7990637 118.86 µM 0.394321465918129 0.308181552308791 no 1023 0.346671858503282 390 2033102 YER133W GLC7
SGTC_1082 camptothecin 424.86 nM 0.392192145826658 0.309034405752062 no 1024 0.347458123476189 409 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_992 3909-8734 162 µM 0.391769876036426 0.309203659424227 no 1025 0.347614127426143 387 4288319
SGTC_102 gallobenzophenone 83.616 µM 0.391439081632568 0.309336276334139 no 1026 0.347736354609903 398 70837
SGTC_2258 7960471 200 µM 0.39050265034211 0.309711830342246 no 1027 0.348082447939559 389 2974708
SGTC_1171 0368-0077 21.4 µM 0.389915407909641 0.309947444232435 no 1028 0.348299550017561 393 3239779
SGTC_81 0411-0046 9.971 µM 0.387186517073265 0.311043355236428 no 1029 0.349309065522545 362 12925265
SGTC_936 3005-4620 401 µM 0.38599816053195 0.311521119155682 no 1030 0.349749015561391 411 777207
SGTC_2882 9058044 58.44 µM 0.385233169697397 0.311828842230781 no 1031 0.350032335158322 353 18076804
SGTC_1318 1280-3875 124 µM 0.385110313573842 0.311878274244168 no 1032 0.350077843551505 389 373245
SGTC_1018 4259-0013 28.1 µM 0.38510194418412 0.311881641849472 no 1033 0.350080943821091 376 6801262
SGTC_393 acivicin 6.25 µM 0.384985635213806 0.311928442911682 no 1034 0.350124029139275 375 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1399 3562-5772 25 µM 0.384825358890687 0.311992940781681 no 1035 0.350183404817807 364 23847490
SGTC_1060 3448-7350 82 µM 0.384561136327863 0.312099280939497 no 1036 0.350281296228084 370 570178
SGTC_967 1306-0166 352 µM 0.38446073493833 0.312139693024065 no 1037 0.350318496392601 392 4437607
SGTC_1209 2323-2347 50.3 µM 0.384127258590556 0.312273935220836 no 1038 0.35044206449821 379 5412760
SGTC_1860 st056228 74.6 µM 0.383984129990893 0.312331559839189 no 1039 0.350495104989178 422 688679
SGTC_2412 st077135 33.4 µM 0.382021994510246 0.313121992212425 no 1040 0.351222525221778 402 13258915
SGTC_3217 9129673 49.47 µM 0.380513668157191 0.313730195389874 no 1041 0.351782076260616 359 17248312
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.378607731736991 0.314499451485261 no 1042 0.35248958989512 412 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1919 st067113 52.3 µM 0.376805734069071 0.315227498298927 no 1043 0.35315898957246 378 1268243
SGTC_555 4296-0685 37 µM 0.376684192638304 0.315276629603312 no 1044 0.353204155739114 398 2908540 YHR072W ERG7
SGTC_977 1348-1378 135 µM 0.376525708523175 0.31534069934243 no 1045 0.353263053330101 389 X977
SGTC_1790 st045711 43.5 µM 0.37640949917516 0.315387682359651 no 1046 0.353306242545769 360 585119
SGTC_1954 st077032 68.9 µM 0.375883013653484 0.315600575932888 no 1047 0.353501934602736 406 698907
SGTC_698 k064-0052 127 µM 0.375726971979714 0.31566368585908 no 1048 0.353559941961674 389 5088751
SGTC_2114 5491910 81.25 µM 0.374450562830323 0.316180122003557 no 1049 0.354034565376758 416 2849228
SGTC_862 0452-0056 10.2 µM 0.373807265356223 0.316440536725847 no 1050 0.354273856878602 373 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_173 1273-0061 2.693 µM 0.373195075980588 0.316688443056113 no 1051 0.354501630344195 390 2847414 YPL266W DIM1
SGTC_1436 4092-1007 8.32 µM 0.372274693147806 0.317061307408261 no 1052 0.354844169335823 360 2881121
SGTC_945 3381-0768 11.3 µM 0.369367211906868 0.318240401911239 no 1053 0.355927016924047 408 1126236 YIL048W NEO1
SGTC_1089 terbinafine 2.25 µM 0.368791311822341 0.318474170535199 no 1054 0.356141640543188 387 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2145 5634607 200 µM 0.368641236555722 0.318535100771937 no 1055 0.356197577347902 381 308662
SGTC_1967 st070177 51.4 µM 0.368585669821553 0.318557661992019 no 1056 0.356218289244367 413 5729214
SGTC_2125 5246583 200 µM 0.368077073291759 0.318764193739024 no 1057 0.356407882778725 417 835267
SGTC_2382 9035899 200 µM 0.367307718362259 0.319076721692708 no 1058 0.356694748720939 416 6462679
SGTC_2876 9059903 25.97 µM 0.365820517160634 0.31968121827165 no 1059 0.357249504514433 377 6916095
SGTC_408 cantharidin 100 µM 0.365759543626814 0.319706012173618 no 1060 0.357272255311751 373 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_717 1532-0246 73.2 µM 0.365624923061668 0.319760756303607 no 1061 0.357322487511686 356 9561992
SGTC_697 0508-1955 564 µM 0.363730350091577 0.320531609954545 no 1062 0.358029688701917 383 6243113
SGTC_1340 1486-1359 257 µM 0.362834867668564 0.320896228886672 no 1063 0.358364121816783 396 4309068
SGTC_803 4488-1585 147 µM 0.362168987749041 0.321167471246661 no 1064 0.358612876444616 412 747204
SGTC_3100 9120536 49.47 µM 0.362160433073136 0.321170956565942 no 1065 0.358616072629424 389 16421196
SGTC_31 0508-1974 57.237 µM 0.360065607967078 0.322024897217732 no 1066 0.35939903555704 375 6810525
SGTC_1009 4106-0057 9.87 µM 0.359781590098516 0.322140747598207 no 1067 0.359505235770518 418 2928005
SGTC_3176 9106582 49.47 µM 0.356843650100783 0.32334014038537 no 1068 0.360604428294546 371 17018027
SGTC_1898 st060199 18.6 µM 0.356533129973103 0.323467015612861 no 1069 0.360720672928307 370 688866
SGTC_1906 st060206 94.7 µM 0.355730259394549 0.323795155134101 no 1070 0.361021290845381 417 5133468
SGTC_570 0987-0065 62.6 µM 0.354870387796061 0.324146743372352 no 1071 0.361343346816542 419 3104428
SGTC_796 1234-0020 70.7 µM 0.352287030576695 0.32520398102901 no 1072 0.362311506805564 365 46495034
SGTC_82 0054-0107 293.755 µM 0.351765221431005 0.325417702436136 no 1073 0.362507171442932 375 3104697
SGTC_1770 st043884 66.3 µM 0.351050496477466 0.325710531045676 no 1074 0.362775232691757 398 670149
SGTC_1422 4031-0024 15.5 µM 0.350950420113964 0.325751541733279 no 1075 0.362812772215152 412 782427
SGTC_1719 st032227 49.2 µM 0.350942435389209 0.325754813915964 no 1076 0.362815767412375 371 3125804
SGTC_2516 gossypol 71.55 µM 0.350783215304288 0.325820065956286 no 1077 0.362875495150146 392 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3124 9127567 49.47 µM 0.35024029445712 0.326042607473024 no 1078 0.3630791844414 395 17592030
SGTC_2622 2-methoxyxanthone 59.94 µM 0.349932684645875 0.326168723258921 no 1079 0.36319460855876 380 71034 A hepatoprotective.
SGTC_512 prima-1 270 µM 0.349134282584589 0.326496149852608 no 1080 0.363494250107328 374 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_3265 9137266 49.47 µM 0.348943319915263 0.326574483925754 no 1081 0.363565931083243 386 17224265
SGTC_2963 9082507 9 µM 0.346355124256609 0.327636930859405 no 1082 0.364537922997374 396 16459611
SGTC_275 trichlorophene 5.69 µM 0.345989733878631 0.327787035303879 no 1083 0.364675215004626 386 62616
SGTC_2186 6124449 200 µM 0.34558600858808 0.327952920311161 no 1084 0.36482693117994 401 3834182 YLR033W RSC58
SGTC_1861 st057647 17.4 µM 0.34423125661535 0.328509816654514 no 1085 0.365336188835295 442 688668
SGTC_584 0986-0246 15.4 µM 0.343708307847708 0.328724886640622 no 1086 0.365532831333826 420 53315 YDR232W HEM1
SGTC_3195 9113082 49.47 µM 0.343535289258914 0.328796055447171 no 1087 0.365597898660829 406 17018038
SGTC_3280 9140961 49.47 µM 0.343478837242886 0.328819277547663 no 1088 0.36561912948124 390 4901226
SGTC_1973 st070275 50.2 µM 0.341632940580758 0.32957896923854 no 1089 0.366313572079662 391 17118334
SGTC_1374 2889-5571 141 µM 0.341216294740144 0.32975054022125 no 1090 0.366470378591007 372 2853281
SGTC_2561 acetosyringone 100 µM 0.341106193458167 0.329795884918513 no 1091 0.366511819422242 422 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3353 9151644 39.2805 µM 0.340446552157437 0.330067607469789 no 1092 0.366760133251363 433 4909158
SGTC_3314 9135860 59.4275 µM 0.340399094930969 0.330087159733227 no 1093 0.366778000090406 397 25252478
SGTC_16 erodoxin 22.806 µM 0.34009506761946 0.330212429264071 no 1094 0.366892468050931 400 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2703 st077852 53.4 µM 0.339866455430778 0.330306637753198 no 1095 0.3669785495985 392 6281836
SGTC_1242 0402-0103 60.1 µM 0.339841059404777 0.330317103831355 no 1096 0.366988112621436 382 432868
SGTC_768 0384-0033 77.3 µM 0.339776500325585 0.330343710180942 no 1097 0.367012423093927 393 3965305 YMR134W ERG29
SGTC_608 k048-0125 159 µM 0.338591049851933 0.330832415194154 no 1098 0.367458912970053 406 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_445 e6 berbamine 66 µM 0.335335158567887 0.332176146856647 no 1099 0.368686137409958 403 6610268 A calcium/calmodulin antagonist.
SGTC_84 0443-0269 128.823 µM 0.334966529010387 0.332328419619762 no 1100 0.36882516753663 430 6150058
SGTC_633 0437-0093 97.7 µM 0.334681890597462 0.332446016429149 no 1101 0.368932531811041 399 2831118
SGTC_3024 9090631 49.47 µM 0.33448584404949 0.33252702158567 no 1102 0.36900648559847 395 25236383
SGTC_3330 9141424 71.43 µM 0.332888782535816 0.333187208097696 no 1103 0.369609118621778 378 27261020
SGTC_2688 kanamycin b 96.69 µM 0.331372405484867 0.333814520384428 no 1104 0.370181602895426 392 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2608 thymoquinone 42.66 µM 0.330669904902693 0.334105296542565 no 1105 0.370446918525949 388 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3237 9133362 49.47 µM 0.329443238562619 0.334613271973242 no 1106 0.370910345220834 435 43845137
SGTC_2995 9067767 71.4286 µM 0.328281313257439 0.335094716820607 no 1107 0.371349485925046 391 11673567
SGTC_3127 9126946 49.47 µM 0.32827667510314 0.3350966391879 no 1108 0.37135123921575 419 27243249
SGTC_86 0417-1630 471.922 µM 0.328099752180811 0.335169971331091 no 1109 0.37141812068149 396 3634867
SGTC_2418 pentamidine 31.67 µM 0.327960249716481 0.335227797633897 no 1110 0.371470858978592 407 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1922 5578187 25 µM 0.327295827005558 0.33550326647262 no 1111 0.37172207417911 407 1350412
SGTC_425 3825-7017 13.1 µM 0.327073920403776 0.335595288386992 no 1112 0.371805988230294 447 3397440
SGTC_227 fluconazole 33.516 µM 0.326635572893138 0.335777094636445 no 1113 0.371971767374516 423 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_477 mead ethanolamide 10 µM 0.325140719913694 0.336397379296435 no 1114 0.372537285858478 385 16061185
SGTC_1035 k081-0041 55.2 µM 0.325074166121187 0.336425005960699 no 1115 0.372562470253875 431 731709
SGTC_1381 2324-0066 62.1 µM 0.324606256712221 0.336619261380509 no 1116 0.372739545645585 414 10885928
SGTC_1351 1496-0003 46.5 µM 0.323145325435315 0.337226056256094 no 1117 0.373292592649209 401 3891978
SGTC_1692 fluoroquinolonic acid 71 µM 0.322691509023013 0.337414634313182 no 1118 0.373464441625294 413 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1961 st076550 68.7 µM 0.321999473670835 0.337702280061506 no 1119 0.373726546624103 390 1579337
SGTC_2539 epi(13)torulosol 80 µM 0.320870387692153 0.338171790215684 no 1120 0.374154307752179 385 6708597
SGTC_1600 coumarin 106 71.1 µM 0.320667686953226 0.338256106361916 no 1121 0.374231118592214 430 100336 A hepatotoxic, DNA x-linker.
SGTC_1219 1469-0211 33.1 µM 0.320502225571507 0.338324938301501 no 1122 0.374293821757737 446 6822282
SGTC_2046 4110841 106 µM 0.319305394594346 0.33882298078725 no 1123 0.374747471169789 419 44119630 YMR134W ERG29
SGTC_1928 4'-methoxychalcone 40.3 µM 0.317155591077662 0.339718295414344 no 1124 0.375562772438503 431 641818
SGTC_2132 5317594 122.667 µM 0.316170593818578 0.340128813449736 no 1125 0.375936513247046 428 794577
SGTC_763 3453-1109 128 µM 0.314771317892863 0.340712316601116 no 1126 0.376467645267926 428 1560353
SGTC_1196 1588-0294 184 µM 0.313807127907399 0.341114609361718 no 1127 0.376833765187784 424 6144269
SGTC_410 α-linolenic acid 100 µM 0.313805917835021 0.341115114358564 no 1128 0.376834224743254 430 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_560 2332-1943 155 µM 0.313433313274062 0.341270626133238 no 1129 0.376975739008851 400 21177716
SGTC_1877 wortmannin 25 µM 0.313229507639149 0.341355698700842 no 1130 0.377053150864953 422 312145 A covalent inhibitor of PI 3-kinase.
SGTC_3011 9081274 71.4286 µM 0.312965225028699 0.341466027578892 no 1131 0.377153541156865 393 6625322
SGTC_2179 6298986 200 µM 0.312340459214659 0.341726899625205 no 1132 0.37739089746791 418 738374
SGTC_3105 9121040 49.47 µM 0.311605580162212 0.342033846408571 no 1133 0.377670146450662 395 41448907
SGTC_1064 honokiol 6.76 µM 0.310801642328355 0.342369757504419 no 1134 0.377975710540638 400 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1801 st050089 28.441 µM 0.310535558697434 0.34248096329535 no 1135 0.378076861559443 386 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1617 st002906 78 µM 0.31027060726948 0.342591709468157 no 1136 0.378177590479188 427 5150859
SGTC_2664 lyso-paf C-16 73.48 µM 0.308970230970901 0.343135445499279 no 1137 0.378672085935778 411 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1499 4480-0877 67.3 µM 0.308850148383129 0.343185672932108 no 1138 0.378717759901198 428 2861909
SGTC_1779 st039427 55 µM 0.308172838675908 0.343469025880091 no 1139 0.37897540947408 421 1124498
SGTC_1881 5652484 16 µM 0.306709592431064 0.344081476099752 no 1140 0.379532213888598 429 2255129
SGTC_310 1273-0058 1.06 µM 0.30643182019093 0.344197785550749 no 1141 0.379637941931338 387 2734232
SGTC_1990 st072050 59.8 µM 0.305443987130819 0.344611532697931 no 1142 0.380014012250693 386 17233948
SGTC_51 1013-0126 23.419 µM 0.303482507877261 0.345433635746686 no 1143 0.380761087993194 434 1627850
SGTC_1867 st057372 64 µM 0.302689486124811 0.345766217569792 no 1144 0.381063255503669 404 688837
SGTC_853 0419-0306 21 µM 0.30095276626116 0.346494988270781 no 1145 0.381725256349569 405 762713
SGTC_2921 7974240 10.71 µM 0.300720738356802 0.346592396043156 no 1146 0.381813726722854 410 2979074 YDR527W RBA50
SGTC_2833 9001315 45.46 µM 0.299087996928055 0.347278124708251 no 1147 0.382436452209337 383 2989378
SGTC_177 1327-0068 8.361 µM 0.298324619118209 0.347598904519789 no 1148 0.382727707971172 380 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2746 daunorubicin 9.88 µM 0.298098454083664 0.347693962542879 no 1149 0.382814010713883 425 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3231 9132313 49.47 µM 0.297658213239731 0.347879024899654 no 1150 0.382982019732186 414 4905967
SGTC_3318 9139014 38.6185 µM 0.297115459932952 0.348107229911473 no 1151 0.38318918086124 444 16643984
SGTC_3287 9117173 37.0625 µM 0.294479050136737 0.34921651104039 no 1152 0.384195934827516 398 2789709
SGTC_327 1273-0057 3.96 µM 0.29446484452429 0.34922249161574 no 1153 0.384201361584594 423 3108138
SGTC_1492 4158-0558 28.5 µM 0.294452548527345 0.349227668271511 no 1154 0.384206058858228 427 3967268
SGTC_1039 k821-0043 94 µM 0.293913954356344 0.34945444572823 no 1155 0.38441182739329 419 15992768
SGTC_502 l-744,832 89.3 µM 0.292503379459813 0.350048629052401 no 1156 0.384950888189043 449 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_3090 9117696 49.47 µM 0.291166764949724 0.350611996676609 no 1157 0.385461889806256 436 7923821
SGTC_2121 5257820 149.641 µM 0.290476140968439 0.350903215612743 no 1158 0.385726000523702 432 791256
SGTC_2602 kawain 100 µM 0.289935998903352 0.351131041135852 no 1159 0.385932600380304 422 5369129
SGTC_1458 k015-0034 6.33 µM 0.289174925219805 0.351452143810411 no 1160 0.386223759651077 424 3598957
SGTC_652 0437-0092 114 µM 0.288713986694678 0.351646668793725 no 1161 0.386400129233302 405 3091274
SGTC_364 0083-0097 67.7 µM 0.288449657878155 0.351758238204133 no 1162 0.386501280347142 391 5207356
SGTC_1216 1165-0504 9.65 µM 0.287880768376924 0.351998401619925 no 1163 0.386719004319026 429 6304004
SGTC_1727 st034309 9.9045 µM 0.286802759234919 0.352453657809795 no 1164 0.387131675048473 443 870305
SGTC_3150 9097574 49.47 µM 0.286245158045653 0.352689222497031 no 1165 0.387345179451971 435 17217476
SGTC_3336 9143619 71.43 µM 0.284894401434521 0.35326009835825 no 1166 0.387862522667746 418 45595730
SGTC_761 k216-0224 480 µM 0.28429712148569 0.353512634668546 no 1167 0.388091345949194 452 1340404
SGTC_1296 1068-0102 11.9 µM 0.281562461927463 0.354669699946392 no 1168 0.389139513551295 440 767053
SGTC_1136 pergolide 1.05886 µM 0.281317347919947 0.354773476143081 no 1169 0.389233502827568 450 47811 A dopamine receptor agonist.
SGTC_2175 5807670 165.306 µM 0.28072677840153 0.355023555306116 no 1170 0.389459984066276 405 241186
SGTC_831 k061-1017 217 µM 0.280652967433416 0.355054815266811 no 1171 0.389488292942535 443 1240153
SGTC_333 3486-0131 40.1 µM 0.280364467503589 0.355177008314573 no 1172 0.389598947553365 432 6744690
SGTC_1960 st011366 51.8 µM 0.27980507148076 0.355413980798928 no 1173 0.389813530290898 433 3972846
SGTC_1640 st009078 66.4 µM 0.279687733643687 0.355463694789703 no 1174 0.389858545018296 432 690618
SGTC_1410 3909-8106 77.9 µM 0.279048520532533 0.355734561383734 no 1175 0.390103794523749 439 1039210
SGTC_1720 st037298 9.481 µM 0.278756087033139 0.355858504395206 no 1176 0.39021600827035 429 597396
SGTC_2591 skatole 100 µM 0.278571467463127 0.355936760136555 no 1177 0.390286855937899 434 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2739 tacrine 100.86 µM 0.276969326555063 0.35661612325443 no 1178 0.390901829484191 427 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1096 rimcazole 32.2 µM 0.27683093053526 0.356674829336385 no 1179 0.390954964912713 444 18528119 A dopamine reuptake inhibitor.
SGTC_742 0kpi-0133 140 µM 0.276648706648405 0.35675213189969 no 1180 0.391024930609815 444 2728852
SGTC_1065 prochlorperazine maleate 2.48 µM 0.275887583599686 0.357075077198996 no 1181 0.391317205404886 456 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_147 4466-0538 29.23 µM 0.274451296042572 0.357684774363588 no 1182 0.391868913589423 385 6742687 YHR072W ERG7
SGTC_1806 st050005 60.3 µM 0.274152797509374 0.357811531207575 no 1183 0.391983600474423 424 5194765
SGTC_2860 9025725 38.96 µM 0.273290833823005 0.35817765045217 no 1184 0.392314830397063 441 40546248
SGTC_1352 1496-0991 99 µM 0.271208816147709 0.359062525385396 no 1185 0.393115216351742 460 3000039
SGTC_2159 5658611 73.75 µM 0.269965815546468 0.359591172105654 no 1186 0.393593276345512 441 793844
SGTC_253 dyclonine 31.25 µM 0.269602700067452 0.359745655477521 no 1187 0.393732961444542 399 3180 An oral anasthetic.
SGTC_106 0092-0003 11.579 µM 0.269347345092969 0.359854307089023 no 1188 0.393831200878674 439 1072148
SGTC_2919 7978188 46.38 µM 0.269333336472906 0.359860267978762 no 1189 0.393836590430413 407 2980291
SGTC_869 0564-0080 44.1 µM 0.268867391496695 0.36005855436014 no 1190 0.39401586553189 401 6843321
SGTC_3089 9117425 49.47 µM 0.268531872220377 0.360201360432109 no 1191 0.39414497248137 441 9401657
SGTC_1950 st077106 7.18 µM 0.268070334507821 0.360397835229808 no 1192 0.394322590003348 389 13831864
SGTC_1742 st038235 28.8875 µM 0.26803084967869 0.360414645479728 no 1193 0.394337786310264 472 564103 YBR002C RER2
SGTC_18 0111-0177 500 nM 0.26790535780077 0.360468074115705 no 1194 0.39438608474015 426 721752
SGTC_1055 3448-0672 86 µM 0.263862781181221 0.362190668464564 no 1195 0.395942827915092 423 748378
SGTC_1448 4255-0083 152 µM 0.263606073357953 0.362300149728824 no 1196 0.396041739078097 443 5399660
SGTC_1271 0832-2808 169 µM 0.26074885292181 0.363519461338372 no 1197 0.397143094822385 451 3663794
SGTC_2499 avocadenofuran 51.48 µM 0.259685894294308 0.363973430106971 no 1198 0.397553037090053 421 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_12 0849-0099 9.267 µM 0.25963809534098 0.36399384859344 no 1199 0.397571473970549 448 6071388
SGTC_2926 9010726 65.15 µM 0.259304556782568 0.364136338453145 no 1200 0.39770013191047 408 2994293
SGTC_1810 st050138 53 µM 0.257356624464317 0.364968882524488 no 1201 0.398451742015088 459 3444541
SGTC_225 nsc-122657 1.016 µM 0.25692707875395 0.36515255573369 no 1202 0.398617533130715 434 275685
SGTC_3284 9108171 64.8615 µM 0.255431194129585 0.365792435372371 no 1203 0.399195040115688 447 8687505
SGTC_2040 5100729 123 µM 0.255263257312683 0.365864295384579 no 1204 0.399259888252632 429 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1522 st012842 45.6 µM 0.255263037564384 0.365864389417762 no 1205 0.399259973109389 453 3491067 YOR116C RPO31
SGTC_2777 climbazole 1.536 µM 0.255059301658996 0.365951574153069 no 1206 0.399338648658913 451 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_3337 9144342 33.5465 µM 0.254432626872256 0.366219790562153 no 1207 0.399580673754844 409 17682949
SGTC_2154 5570129 200 µM 0.253842152497569 0.366472573041163 no 1208 0.399808753376442 462 673366
SGTC_2800 7887935 81.82 µM 0.253807663926396 0.366487339413731 no 1209 0.399822076164055 423 2961002
SGTC_3343 9148379 18.9835 µM 0.252536010158438 0.367031939152641 no 1210 0.400313391879457 439 1955036
SGTC_2669 eugenol 100 µM 0.252432926329789 0.367076097681481 no 1211 0.400353226236835 439 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_290 2043-6722 48.1 µM 0.25183929126133 0.367330430274771 no 1212 0.400582642916513 438 773758 YLR208W SEC13
SGTC_1712 st032288 53.4 µM 0.250989650235144 0.367694545420773 no 1213 0.40091105552112 438 2883011
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.249969953314631 0.368131695342478 no 1214 0.401305292455958 405 5282362
SGTC_2374 9071832 200 µM 0.249096616176609 0.368506235805651 no 1215 0.401643023439361 437 17381698
SGTC_1976 st070609 63.5 µM 0.248788592131243 0.368638365213872 no 1216 0.401762157938806 462 682556
SGTC_753 1322-0200 289 µM 0.248782859994141 0.368640824207745 no 1217 0.401764375044772 426 5403907
SGTC_2713 st079149 53.4 µM 0.246965662771645 0.36942064299279 no 1218 0.402467399106448 433 3103253
SGTC_1952 st077036 64.1 µM 0.246326223587099 0.369695175290883 no 1219 0.402714855866085 428 2937007
SGTC_389 tpck 16.7 µM 0.24546349946073 0.370065676430144 no 1220 0.403048783487787 405 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_262 fenpropimorph 62.5 µM 0.243533331987946 0.370895032724849 no 1221 0.403796133501661 457 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_754 3474-0146 171 µM 0.242417596494134 0.371374717047399 no 1222 0.404228300456022 401 24762078
SGTC_3218 9131285 49.47 µM 0.241689672674058 0.371687778606602 no 1223 0.404510316190378 449 17156417
SGTC_1097 itavastatin 7.23 µM 0.240982777685026 0.371991877437797 no 1224 0.404784232325926 451 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.240092979386507 0.372374772881094 no 1225 0.4051290883493 455 6710655
SGTC_540 1187-0821 17.3 µM 0.239039665784146 0.372828194847883 no 1226 0.405537412643562 472 847520
SGTC_295 k015-0027 31 µM 0.237915466147295 0.37331232570279 no 1227 0.40597332982302 423 3887424
SGTC_2460 5552655 174.22 µM 0.237719553112493 0.373396715146036 no 1228 0.40604930857653 411 5401989
SGTC_424 splitomicin 100 mM 0.237701545149881 0.373404472371855 no 1229 0.406056292580183 442 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2696 st077691 74.316 µM 0.236436219669485 0.373949660393491 no 1230 0.406547096765899 469 757133
SGTC_1680 diphenhydramine 100 µM 0.23611054103744 0.374090025696515 no 1231 0.406673447293732 459 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_611 3453-1652 23.7 µM 0.234360839420709 0.374844420704937 no 1232 0.40735242886009 433 1560575
SGTC_482 fipronil 114 µM 0.23434878106483 0.374849621407702 no 1233 0.407357109141469 427 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_44 0929-0055 61.211 µM 0.233544250726284 0.375196662303148 no 1234 0.407669406133298 432 1379590
SGTC_1135 dihydrocapsaicin 536.708 nM 0.23234599784661 0.375713725965483 no 1235 0.40813464433494 441 107982 A Capsaicinoid.
SGTC_2638 epoxomicin 18 µM 0.229179893655974 0.377081018483675 no 1236 0.409364549632968 448 9915668 A protesome inhibitor.
SGTC_9 0092-0002 10.449 µM 0.22890869306353 0.37719820932348 no 1237 0.409469941931062 436 759368
SGTC_535 2293-4129 48.2 µM 0.227519612250243 0.377798634201224 no 1238 0.410009860355787 457 396118 YIL048W NEO1
SGTC_1715 st032160 10.2275 µM 0.223012044435412 0.379749040682046 no 1239 0.411763066225095 464 5289825
SGTC_2955 9076254 12.21 µM 0.222857820990131 0.379815827022474 no 1240 0.411823082391615 458 16459619
SGTC_1956 st077085 54 µM 0.221663656144221 0.380333080367261 no 1241 0.412287862235138 467 24208685
SGTC_2265 7929201 200 µM 0.219246534137919 0.381380712749126 no 1242 0.413229004081771 467 1265108
SGTC_2187 6125751 200 µM 0.21920584825874 0.381398354343891 no 1243 0.413244850008659 439 874498
SGTC_877 0771-0151 33.1 µM 0.218777377281707 0.381584156395991 no 1244 0.413411735150182 458 6166523
SGTC_2487 5918373 44.05 µM 0.218602537348996 0.381659981784832 no 1245 0.413479838043734 491 2876279
SGTC_1031 k035-0009 16 µM 0.218537747033428 0.38168808150126 no 1246 0.413505075548038 464 5180959
SGTC_3179 9107801 49.47 µM 0.216249975128229 0.382680692379573 no 1247 0.414396450240516 400 4818259
SGTC_629 3448-6466 76.7 µM 0.215024173559664 0.383212856813016 no 1248 0.414874235786791 461 573744
SGTC_403 arphamenine a 50 µM 0.214954460228833 0.383243128505541 no 1249 0.414901412020293 473 5487158 An arginine aminopeptidase inhibitor.
SGTC_1556 plumbagin 1.48 µM 0.213613908264713 0.383825376245828 no 1250 0.41542407625602 460 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_266 formosanin C 406 nM 0.212895541120364 0.384137495813515 no 1251 0.415704220167004 449 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1772 st048439 82.2 µM 0.212351838921518 0.384373776104171 no 1252 0.415916277930446 456 2927068 YDL195W SEC31
SGTC_759 3486-0358 89.3 µM 0.212188235889781 0.384444882578793 no 1253 0.415980092092197 461 875103
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.211330887424278 0.384817573840379 no 1254 0.416314541234939 481 7104
SGTC_1184 1269-1718 139 µM 0.211137350186947 0.384901719642754 no 1255 0.41639004794096 435 5403821
SGTC_2909 7941780 10.49 µM 0.210702858179828 0.385090647105852 no 1256 0.416559572085621 450 1243215
SGTC_1643 st009866 20.2 µM 0.210614253467987 0.385129177893162 no 1257 0.416594144565632 454 3156273 YOR207C RET1
SGTC_957 1187-1561 14.1 µM 0.20973556082538 0.385511348923942 no 1258 0.416937034621745 466 1538454
SGTC_2618 avocadyne 43.43 µM 0.209715821975868 0.385519935247875 no 1259 0.416944737990888 454 3015189
SGTC_1420 4'-methoxyflavone 42 µM 0.209494516548051 0.385616206101253 no 1260 0.417031107790664 460 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1308 1187-1617 41.4 µM 0.20864514966546 0.385985757555915 no 1261 0.417362630916515 461 2882570
SGTC_432 NS 1619 61.3 µM 0.2077381502009 0.386380498650891 no 1262 0.417716713938928 411 4552 A K+/calcium channel activator.
SGTC_2508 celastrol 40.54 µM 0.207439942162079 0.386510309410399 no 1263 0.417833145799836 417 122724 Celastrol is a natural product and antioxidant.
SGTC_2935 9038016 29.96 µM 0.207369998784522 0.386540757789737 no 1264 0.417860455421401 466 6463195
SGTC_264 promethazine 12.5 mM 0.206865288693851 0.386760493416012 no 1265 0.41805753286851 470 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_609 0986-0026 86.3 µM 0.205862649457398 0.387197120089611 no 1266 0.418449100958693 459 2848610
SGTC_1782 st039423 80.636 µM 0.205790917399348 0.387228363254298 no 1267 0.418477118110734 442 2068169
SGTC_1050 3232-1156 69.3 µM 0.204452511909547 0.387811444515365 no 1268 0.418999949064581 470 700529
SGTC_2128 5255449 168.493 µM 0.203704137901852 0.388137586796668 no 1269 0.419292354210429 421 736008
SGTC_57 miconazole 162.5 nM 0.203606832750958 0.388179998298669 no 1270 0.4193303766163 460 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3183 9108214 49.47 µM 0.203582990341161 0.388190390474173 no 1271 0.419339693255305 477 4974831
SGTC_50 0929-0078 56.389 µM 0.202224170733265 0.388782790364748 no 1272 0.419870738979972 462 1377751
SGTC_2479 5617353 43.85 µM 0.201500630188356 0.389098335482423 no 1273 0.420153568359313 467 2731746
SGTC_2075 5212009 200 µM 0.200145233775626 0.389689637619123 no 1274 0.420683498779032 482 780898
SGTC_889 0919-1524 82.7 µM 0.199830058008627 0.389827172131013 no 1275 0.420806746264058 432 3905452
SGTC_394 menadione 8.33 µM 0.198315162227571 0.390488425499172 no 1276 0.421399244767464 468 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2653 dihydrofissinolide 100 µM 0.195835827253443 0.391571340382619 no 1277 0.422369333450284 447 6857746
SGTC_3097 9117246 49.47 µM 0.195240289781018 0.391831582620823 no 1278 0.42260241961695 461 16423892
SGTC_594 1487-1584 10.8 µM 0.193496239045106 0.392593988478383 no 1279 0.423285175604096 448 5013332
SGTC_1743 st037606 46.3785 µM 0.193191699373785 0.392727159331259 no 1280 0.423404419611963 427 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2967 9089538 49.85 µM 0.192310179605937 0.393112706085916 no 1281 0.423749622525773 462 728216
SGTC_1805 st050013 60.3 µM 0.189591473978287 0.394302434317567 no 1282 0.424814634407641 466 4037144
SGTC_793 0488-0545 106 µM 0.18941261466234 0.394380739359973 no 1283 0.424884719177369 498 292548
SGTC_137 0438-0332 85.389 µM 0.187694704925496 0.395133061363469 no 1284 0.425557990679089 477 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_3063 1327-0034 4 µM 0.187325849632517 0.395294644783452 no 1285 0.425702578317292 485 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3064 1327-0027 10 µM 0.186810356281191 0.395520495690886 no 1286 0.425904663362441 479 16000455 YPR107C YTH1
SGTC_1483 3453-0561 55.9 µM 0.185452037475793 0.396115778002351 no 1287 0.42643724810341 465 4546991
SGTC_926 2268-1401 59.4 µM 0.185297598054849 0.39618347634352 no 1288 0.426497810941753 490 2931578
SGTC_2329 6138490 200 µM 0.184896336472957 0.396359383522746 no 1289 0.426655172260615 450 720019
SGTC_2320 7373003 200 µM 0.184519411454197 0.396524641131035 no 1290 0.426803000231699 440 5415828
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.184152767168412 0.396685409130045 no 1291 0.426946806019575 476 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_922 1866-0035 480 µM 0.183115214896705 0.397140455273948 no 1292 0.427353808929588 468 3156169
SGTC_355 1311-2252 105 µM 0.183010772804359 0.397186268900441 no 1293 0.427394782949865 460 5338538
SGTC_1396 3511-0007 98.6 µM 0.181535386645984 0.397833599777859 no 1294 0.427973680013128 478 X1396
SGTC_2820 7989630 71.43 µM 0.181010473746405 0.398063975118772 no 1295 0.42817967747781 467 2984098
SGTC_2496 diffractaic acid 79.83 µM 0.180986337457221 0.398074568980763 no 1296 0.428189150023985 440 94870 An apoptosis inducer which activates caspases.
SGTC_815 1582-0027 36.9 µM 0.179595046957884 0.398685358776617 no 1297 0.428735246706415 473 3128206
SGTC_3080 9117754 49.47 µM 0.178964319125973 0.398962336173392 no 1298 0.428982859272154 469 9550191
SGTC_212 3807-4682 38.772 µM 0.178859257733511 0.399008477710299 no 1299 0.429024107230699 447 3125501 YBL034C STU1
SGTC_2997 9067075 71.4286 µM 0.178189849152014 0.399302505985605 no 1300 0.429286940677385 478 27209819
SGTC_505 gw-5074 63.9 µM 0.177392716005246 0.399652709986148 no 1301 0.429599964186229 477 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3177 9107506 49.47 µM 0.176272730290328 0.40014488896425 no 1302 0.43003984232 474 8897194
SGTC_2148 5546263 113.568 µM 0.174539756629504 0.400906758577235 no 1303 0.430720644487759 446 792097
SGTC_3211 9128781 49.47 µM 0.17326686561206 0.401466601773932 no 1304 0.431220833576595 452 17194361
SGTC_1494 4358-1428 177 µM 0.17151628585724 0.402236872383722 no 1305 0.4319089129611 473 1564571
SGTC_808 0711-0032 135 µM 0.171185677350466 0.40238238578403 no 1306 0.432038884539557 477 4252555
SGTC_217 ketoconazole 989 nM 0.171032832132458 0.402449663361915 no 1307 0.43209897481605 464 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3139 9095020 49.47 µM 0.170661623437834 0.402613069586739 no 1308 0.432244920058151 490 25236292
SGTC_2449 5812982 45.77 µM 0.169200784736698 0.403256296385488 no 1309 0.432819356279951 473 776185
SGTC_2747 doxorubicin 7.63 µM 0.169127705397675 0.403288481086134 no 1310 0.432848096538668 488 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3077 9117319 49.47 µM 0.168505541938094 0.403562513147285 no 1311 0.433092792087477 481 17154678
SGTC_2948 9070189 9.45 µM 0.167518651414564 0.403997286416802 no 1312 0.433480986590286 476 6473636 YDL196W YDL196W
SGTC_2053 5265679 138 µM 0.166925751198046 0.404258544871773 no 1313 0.43371423544653 466 764595
SGTC_320 4092-0846 5.34 µM 0.166877177160255 0.404279950667824 no 1314 0.433733345653787 462 1359356
SGTC_357 1325-0123 420 µM 0.165576913153924 0.404853062383367 no 1315 0.43424495855545 476 1098503
SGTC_990 3985-0011 41.3 µM 0.165276773403097 0.404985382722918 no 1316 0.434363069766268 481 5399565 YGL099W LSG1
SGTC_1791 st048313 56.1 µM 0.164781042501505 0.405203955635427 no 1317 0.43455816297327 478 1204976
SGTC_778 3456-2434 196 µM 0.162806380366685 0.40607489756804 no 1318 0.435335442246234 443 5539063
SGTC_681 1642-0006 26.6 µM 0.160780684154182 0.40696883173213 no 1319 0.436133069554294 486 4446530
SGTC_1828 st055811 49 µM 0.160554722781111 0.407068578009787 no 1320 0.436222059062575 493 5877589
SGTC_1546 5-methoxyflavanone 78.7 µM 0.159186446376323 0.407672705698698 no 1321 0.436760990962083 463 147795
SGTC_3144 9087057 49.47 µM 0.158574979765173 0.407942754338313 no 1322 0.437001871294263 494 17249618
SGTC_1350 1495-0454 146 µM 0.156929493905733 0.408669685009266 no 1323 0.437650207532241 485 1069057
SGTC_707 0865-0008 204 µM 0.155038041143306 0.40950566531928 no 1324 0.438395663690259 491 723043
SGTC_142 0335-0849 62.6745 µM 0.154798430933859 0.409611597190207 no 1325 0.438490114116825 464 3889043 YPR107C YTH1
SGTC_1704 st028805 70.8 µM 0.154106722020402 0.409917439266518 no 1326 0.438762794095959 453 2876101
SGTC_1066 ketoconazole 628 nM 0.152579967872014 0.410592693954049 no 1327 0.43936476166418 491 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_3014 9081533 49.47 µM 0.151955295368414 0.410869051407995 no 1328 0.439611097613828 487 21367265
SGTC_710 3448-4187 58 µM 0.151386024893853 0.411120937336903 no 1329 0.439835606464635 456 3946412
SGTC_885 0865-0106 16.8 µM 0.150663482973392 0.411440694268085 no 1330 0.440120590353135 493 2793380
SGTC_1978 st071761 42 µM 0.150149401965532 0.411668233808521 no 1331 0.440323372302959 442 5147680
SGTC_1133 3473-0247 50 µM 0.149603197953484 0.411910023995701 no 1332 0.440538842489918 477 711311
SGTC_3116 9124943 49.47 µM 0.148906314060768 0.412218564764291 no 1333 0.440813779432406 483 41905195 YPL160W CDC60
SGTC_2492 derrusnin 100 µM 0.148746566005464 0.412289299819135 no 1334 0.440876807789072 485 1715307 Part of coumarin class of compounds.
SGTC_1375 2910-0797 186 µM 0.148622992448919 0.412344019073965 no 1335 0.440925564578727 502 742508
SGTC_683 panaxydol 45 µM 0.147744027390008 0.412733280192821 no 1336 0.441272392032515 468 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_553 k007-0256 45.7 µM 0.14756502243012 0.412812565402251 no 1337 0.44134303044272 462 6287000
SGTC_1275 0867-0008 21.1 µM 0.146414519903541 0.413322232882008 no 1338 0.441797082802801 470 3422836
SGTC_864 0469-0573 172 µM 0.146165745346945 0.413432458139542 no 1339 0.441895273173644 478 689425
SGTC_2063 5246145 200 µM 0.146070935679186 0.413474467527479 no 1340 0.441932695128722 473 711240
SGTC_523 1934-0222 13.7 µM 0.146033924013344 0.413490867362574 no 1341 0.441947304000009 498 1361595
SGTC_1647 st011722 22.4 µM 0.146023512790614 0.413495480592989 no 1342 0.441951413427024 457 2854783
SGTC_2537 larixol 68.93 µM 0.1457343347319 0.413623620650191 no 1343 0.442065557762896 501 6708759
SGTC_3107 9121808 49.47 µM 0.14475359570294 0.414058272377554 no 1344 0.442452710746542 457 662681
SGTC_3282 9108498 15.4605 µM 0.144102672544025 0.414346811849289 no 1345 0.442709697182808 470 16459645
SGTC_2958 9077254 16.72 µM 0.143807835390264 0.414477521694195 no 1346 0.442826107723672 461 16457351
SGTC_1760 st045453 10.4495 µM 0.143381714011679 0.41466645036891 no 1347 0.44299436192882 511 3323419 YIL048W NEO1
SGTC_1305 1181-0477 144 µM 0.142149457074985 0.415212904865438 no 1348 0.443480976839991 470 6252086
SGTC_2444 5485484 36.41 µM 0.140477815547256 0.415954470131956 no 1349 0.444141239650928 484 6790631
SGTC_1405 3909-7894 12 µM 0.14029332001687 0.416036333507837 no 1350 0.444214120991661 483 7104060
SGTC_33 0986-0033 35.816 µM 0.139326382026449 0.41646543759448 no 1351 0.44459612167561 477 2848082
SGTC_1681 tripelennamine 100 µM 0.139317690732016 0.416469295036548 no 1352 0.444599555511724 450 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.139230989820132 0.416507775791561 no 1353 0.444633810328718 486 2333 A French combination drug.
SGTC_3151 9099821 49.47 µM 0.139158326546833 0.416540026790944 no 1354 0.444662519308707 466 17174189
SGTC_13 0199-0087 65 µM 0.138941882310073 0.416636097123101 no 1355 0.444748037314381 481 4589825
SGTC_2916 7875993 68.79 µM 0.138233158183926 0.416950704243591 no 1356 0.445028075100347 488 1299250
SGTC_1297 1068-0111 14.1 µM 0.138018014230711 0.417046218538198 no 1357 0.445113090250699 495 767057
SGTC_462 ag-879 158 µM 0.136365948346254 0.41777982466425 no 1358 0.445765995729907 498 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_715 0868-0130 184 µM 0.135992609349295 0.417945647002079 no 1359 0.445913561785349 464 2876258
SGTC_3094 9117742 49.47 µM 0.13555415947034 0.418140407629837 no 1360 0.446086873147339 493 17149698
SGTC_1427 4048-4900 550 nM 0.135508361113466 0.418160752543198 no 1361 0.446104977009957 488 24132586
SGTC_2161 5662504 8.5105 µM 0.133165648171263 0.41920174218888 no 1362 0.447031188815925 460 2859334
SGTC_2126 5251174 33.877 µM 0.132434818462432 0.419526604115306 no 1363 0.447320188030422 457 790722
SGTC_2457 5731572 11.68 µM 0.132415739109441 0.419535085835418 no 1364 0.447327733142862 493 2865357
SGTC_3037 9091026 49.47 µM 0.132158027943764 0.41964965491082 no 1365 0.447429649352262 491 25236398 YIL048W NEO1
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.132082075811828 0.419683421785121 no 1366 0.44745968656121 462 688788
SGTC_550 4123-0385 25.7 µM 0.130449912704094 0.420409192983053 no 1367 0.448105239649825 475 5731123
SGTC_1958 st076513 41.9 µM 0.130438076662415 0.420414457087127 no 1368 0.448109921544649 495 732122 YGL099W LSG1
SGTC_2759 disulfiram 3.38 µM 0.130314732090582 0.420469315688067 no 1369 0.448158712467995 475 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.129028853627802 0.421041313433552 no 1370 0.448667408883037 498 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_856 0433-0016 11.3 µM 0.128379728038433 0.42133012758253 no 1371 0.448924236539468 474 3911780
SGTC_657 3534-0529 86.7 µM 0.128245709524956 0.421389761448812 no 1372 0.448977263864103 476 1049549
SGTC_2204 7233102 200 µM 0.126981694895173 0.421952295243198 no 1373 0.449477443307907 491 2172480
SGTC_3186 9110464 49.47 µM 0.126176752270488 0.422310607908682 no 1374 0.449796006637255 480 17018021
SGTC_2913 7966556 36.57 µM 0.125528920581959 0.422599030831474 no 1375 0.450052415400903 500 2976516
SGTC_3178 9107506 49.47 µM 0.122837546430207 0.423797707568763 no 1376 0.451117870820892 484 8897194
SGTC_2426 5582046 32.21 µM 0.122266092897131 0.424052311121743 no 1377 0.451344142218262 472 2251934
SGTC_3031 9088762 49.47 µM 0.122099576882539 0.424126506096004 no 1378 0.451410078485766 461 205253
SGTC_1534 6-azauridine 81.6 µM 0.121448096028099 0.424416813935814 no 1379 0.451668061829842 504 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2908 7930301 100 µM 0.121221879718785 0.424517628291392 no 1380 0.45175764720092 456 2223178
SGTC_2246 7293507 91.5585 µM 0.120610344313499 0.424790186603995 no 1381 0.451999837542123 506 887656
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.120104960016535 0.425015461036893 no 1382 0.45220000165572 484 521171
SGTC_1833 st055984 71 µM 0.120051088741752 0.425039475537383 no 1383 0.452221338801799 463 676288
SGTC_56 0957-0365 83.25 µM 0.119778202238183 0.425161125957056 no 1384 0.452329424852274 500 6752360
SGTC_2864 9034755 47.6 µM 0.118993012991041 0.425511196177646 no 1385 0.452640445638819 503 4930451
SGTC_2917 7979103 53.79 µM 0.118836720007784 0.425580885146485 no 1386 0.452702358221705 503 2980565
SGTC_1397 3532-0190 20.1 µM 0.118394789494926 0.425777948675954 no 1387 0.452877427061902 473 5322280
SGTC_2060 5238662 140 µM 0.118360650108216 0.425793172719162 no 1388 0.452890951612244 471 790130
SGTC_3208 9114115 49.47 µM 0.118294272335284 0.425822773394189 no 1389 0.45291724777506 493 650895
SGTC_1608 st001473 40.5 µM 0.117847992442674 0.426021799443647 no 1390 0.453094050998038 502 7292267
SGTC_156 3474-0145 5.642 µM 0.116794786961376 0.426491568830071 no 1391 0.453511337440768 489 2265471
SGTC_1766 st045414 44.774 µM 0.11478124349576 0.427389974981315 no 1392 0.45430925815351 493 253960
SGTC_769 0302-0231 76 µM 0.114544499637584 0.427495630584518 no 1393 0.45440308644888 502 571869 YER009W NTF2
SGTC_506 n9-isopropylolomoucine 153 µM 0.114521537989576 0.427505878336286 no 1394 0.454412186935682 502 6610355
SGTC_1294 1000-1494 117 µM 0.111724391262907 0.428754604905725 no 1395 0.455520969488165 482 712797 YDL207W GLE1
SGTC_2665 lovastatin 100 µM 0.111135969899072 0.42901738434522 no 1396 0.455754262775607 484 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_729 4092-0585 94.1 µM 0.111039516912801 0.429060461689426 no 1397 0.455792505255 470 2169061
SGTC_960 1222-0186 7.7 µM 0.110919176452088 0.429114208721151 no 1398 0.455840219412497 500 3126296
SGTC_1130 3454-2858 15.9 µM 0.110019712000173 0.429515973390595 no 1399 0.456196870949127 514 715628 YIL048W NEO1
SGTC_1591 genipin 88.4 µM 0.109562714843283 0.42972012875807 no 1400 0.456378090914651 500 442424 A DNA cross-linking agent.
SGTC_497 capsazepine 133 µM 0.109091432740844 0.429930685356461 no 1401 0.456564985008142 506 2733484 A calcium channel blocker.
SGTC_516 3992-2719 87.3 µM 0.108813918493868 0.43005468083849 no 1402 0.456675042005917 457 5350887 YDR037W KRS1
SGTC_1605 st000082 49.1 µM 0.10853892857843 0.43017755523475 no 1403 0.456784101178975 500 1114022
SGTC_899 1083-0020 478 µM 0.107605474231631 0.430594703220738 no 1404 0.45715432720006 503 767123
SGTC_2101 5377231 179.231 µM 0.107210355646094 0.430771299674629 no 1405 0.457311050082642 496 2844213
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.106731726337878 0.430985239405216 no 1406 0.457500906192088 507 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_3301 9125354 19.7965 µM 0.106326331746752 0.431166460219924 no 1407 0.457661720146616 467 41905162
SGTC_1891 st059073 26.2 µM 0.104298011975782 0.43207338324883 no 1408 0.458466427762034 516 688754
SGTC_1198 1612-1005 86.7 µM 0.103846018388781 0.432275532189189 no 1409 0.458645773234204 508 6998509
SGTC_2285 7945142 200 µM 0.103490176104714 0.432434691040482 no 1410 0.458786972981418 506 2970608
SGTC_3262 9137218 49.47 µM 0.101483164794467 0.433332578748465 no 1411 0.459583460553518 505 17650664
SGTC_171 k064-0041 9.68 µM 0.101093747579865 0.433506834490962 no 1412 0.459738020663933 485 53325
SGTC_1944 st076371 56.9 µM 0.10044467910797 0.433797307241348 no 1413 0.459995650148672 517 24208455
SGTC_470 aa-861 153 µM 0.100059781644205 0.433969574418491 no 1414 0.460148432317958 494 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1201 1889-3372 45.9 µM 0.0993401371382279 0.43429169675019 no 1415 0.460434105590152 487 5392199
SGTC_356 1634-0012 32.5 µM 0.0992738647187438 0.43432136335283 no 1416 0.460460414412707 507 735457
SGTC_257 daunorubicin 18.5 µM 0.0986805894165973 0.434586957297368 no 1417 0.460695940516395 504 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2206 7254556 146.969 µM 0.0985326688782579 0.43465318208357 no 1418 0.460754666075939 506 4398905
SGTC_3248 9135562 49.47 µM 0.09766268659757 0.43504271467155 no 1419 0.461100072824111 470 17650701
SGTC_2450 5739737 12.93 µM 0.0974764940935688 0.435126090145804 no 1420 0.46117400015969 517 2262825
SGTC_2247 cerulenin 830 nM 0.0970416010222546 0.435320842922212 no 1421 0.461346678746299 512 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_172 1112-0046 2.638 µM 0.0950641133192664 0.436206593922391 no 1422 0.462131951183111 494 2802135 YIL048W NEO1
SGTC_2104 5389443 200 µM 0.0949057283539233 0.436277551193202 no 1423 0.46219485324586 493 2244536
SGTC_338 4055-0136 114 µM 0.0947958996452945 0.436326756218045 no 1424 0.462238471907832 469 2900563
SGTC_1456 k015-0012 13 µM 0.0923017560545366 0.437444436408497 no 1425 0.463229146599094 500 2989616
SGTC_2846 9008642 19.48 µM 0.0912733676340342 0.437905425618485 no 1426 0.46363768959441 511 2992898
SGTC_1519 esterone 74 µM 0.0912732590207916 0.437905474310322 no 1427 0.463637732744711 485 698 A steroid.
SGTC_672 1441-0018 53.7 µM 0.0903690554313237 0.438310865629953 no 1428 0.463996973121027 494 251141
SGTC_1493 4348-0038 111 µM 0.0901611437064524 0.438404090099573 no 1429 0.464079580677649 516 800424
SGTC_798 1287-0182 476 µM 0.0900536539953705 0.438452288199244 no 1430 0.464122289133366 505 1649755
SGTC_2445 5742597 35.57 µM 0.0892460634590046 0.438814438786056 no 1431 0.464443179028797 502 1774255
SGTC_2715 st079500 56.4 µM 0.089058332181769 0.438898631114511 no 1432 0.464517775930338 506 28246688
SGTC_2936 9038235 15.59 µM 0.0881696857854986 0.439297202101316 no 1433 0.464870905348972 507 4749415
SGTC_1665 st014639 11.4 µM 0.0863124024905849 0.440130419272151 no 1434 0.465609039754357 510 981133 YIL048W NEO1
SGTC_109 0132-0036 33.701 µM 0.0857264136002073 0.440393361685124 no 1435 0.465841952200264 521 67274 A color developer.
SGTC_2601 securinine 100 µM 0.0853716813996477 0.440552548372054 no 1436 0.465982952960486 527 442872 A GABA receptor antagonist.
SGTC_973 1325-0077 65.9 µM 0.0843098954198418 0.441029083980442 no 1437 0.466405022504355 518 2835149
SGTC_1345 1488-0192 31.4 µM 0.0840383149760275 0.44115098457605 no 1438 0.466512984277619 506 658348
SGTC_791 1348-1292 225 µM 0.0838089904475767 0.44125392267975 no 1439 0.466604149913819 516 5437054
SGTC_283 0987-0079 11.7 µM 0.083715654495481 0.441295820014777 no 1440 0.466641255175186 514 411556
SGTC_1832 st054113 55 µM 0.0818783864726845 0.442120679682702 no 1441 0.467371710907965 511 1251267
SGTC_2254 7938975 95.19 µM 0.081833403910341 0.442140878212092 no 1442 0.467389596333837 504 2969277
SGTC_592 k241-0073 46.5 µM 0.0816146571073085 0.442239104278325 no 1443 0.467476572746811 516 4230158
SGTC_2308 7584454 197.62 µM 0.079807074068196 0.443050916750694 no 1444 0.468195348990228 499 893577
SGTC_150 3970-0969 77.2 µM 0.0790119072234337 0.443408113963057 no 1445 0.468511576039923 494 6615640
SGTC_2914 7968218 45.32 µM 0.0789489144741633 0.443436412930583 no 1446 0.468536628252319 516 2977111
SGTC_1794 st048918 76.9 µM 0.0784229350088043 0.443672716068301 no 1447 0.468745815106291 513 672303
SGTC_2495 cafestol 54.53 µM 0.0782186527190292 0.443764497957371 no 1448 0.46882706237481 496 16667697 An anti-infammatory.
SGTC_2521 angolensin 13.4 µM 0.078072695665991 0.443830076777515 no 1449 0.46888511329234 513 821428 A flavenoid.
SGTC_329 k048-0121 21.3 µM 0.0778739259129392 0.443919386931521 no 1450 0.468964170258369 489 6832902
SGTC_2011 4012611 177 µM 0.0767069334490488 0.444443790996762 no 1451 0.469428344350176 507 2049887
SGTC_3058 9093861 49.47 µM 0.076184289757541 0.444678679696087 no 1452 0.469636240659683 515 17217477
SGTC_187 1488-2104 32.728 µM 0.0759350171994392 0.444790715652688 no 1453 0.469735398788579 522 2852859
SGTC_2740 felodipine 17.08 µM 0.0757307505788397 0.444882526905919 no 1454 0.469816655405438 524 3333 L-type calcium channel blocker
SGTC_2476 5806916 10.51 µM 0.0750204202132346 0.44520182046775 no 1455 0.470099232346696 512 2870194
SGTC_2099 5377090 177.372 µM 0.0749432890903279 0.445236493057766 no 1456 0.47012991683303 509 2243829
SGTC_1968 st069590 43.6 µM 0.0746350478539177 0.445375060266444 no 1457 0.470252543862076 520 6384066
SGTC_2852 9023854 51.95 µM 0.0739711339420312 0.445673539727082 no 1458 0.47051667704697 527 19798528
SGTC_727 3032-0951 202 µM 0.0737247376436967 0.44578432132174 no 1459 0.470614707278296 510 3652836
SGTC_1553 gossypol 38.6 µM 0.0730712499598493 0.446078154686067 no 1460 0.470874709844971 513 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1603 st002045 67.8 µM 0.0723870780806039 0.446385816583415 no 1461 0.47114693400734 513 5887985
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.0717001826336787 0.446694735699701 no 1462 0.471420255408859 503 165521
SGTC_2612 dictamnine 15.46 µM 0.0716372161750226 0.446723055375784 no 1463 0.47144531096106 514 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.0710221877699361 0.446999683661036 no 1464 0.471690048396012 489 16623 A steroid.
SGTC_2485 5633444 17.78 µM 0.0709514990620019 0.447031479775976 no 1465 0.471718178146225 516 5724239
SGTC_670 4204-0025 119 µM 0.068324758909295 0.448213239576224 no 1466 0.472763557709511 524 719039
SGTC_1230 0170-0365 3.77 µM 0.0680539276782884 0.448335111776773 no 1467 0.472871352834374 522 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1926 methyl fluorone black 53.6 µM 0.0679948115662558 0.448361714271373 no 1468 0.472894882248884 513 72721 Reacts with homocysteine.
SGTC_247 mechlorethamine 29.705 µM 0.0677559297521719 0.448469214438219 no 1469 0.472989963030145 520 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2379 9035213 200 µM 0.0673141363309912 0.448668037638534 no 1470 0.473165811624998 524 646551
SGTC_2061 5245884 80.95 µM 0.0671547849770129 0.448739754743316 no 1471 0.473229240092005 514 573863
SGTC_1490 4089-0339 670 nM 0.0669294941510807 0.44884115119038 no 1472 0.473318916369372 512 742542
SGTC_1386 3228-0095 33.8 µM 0.0663104992719066 0.449119758863411 no 1473 0.473565312207014 517 870181
SGTC_3197 9113331 49.47 µM 0.065776116263403 0.449360303180572 no 1474 0.473778035754153 499 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2398 5228213 48.84 µM 0.0657516093241652 0.44937133505049 no 1475 0.473787791489332 517 80771 YMR134W ERG29
SGTC_2626 ethyl orsellinate 100 µM 0.0654633392771458 0.449501103585217 no 1476 0.473902547358731 518 75653 A natural product.
SGTC_1455 4262-0120 131 µM 0.0645160315483062 0.449927584522266 no 1477 0.474279671187433 497 1529587
SGTC_2295 7971645 200 µM 0.0642003486653135 0.450069718827871 no 1478 0.474405349887314 513 2978226 YKL099C UTP11
SGTC_690 glyoxal 20.3 µM 0.0641746204172348 0.450081303098222 no 1479 0.47441559285085 523 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1740 st038286 13.222 µM 0.0640191995300701 0.450151283021968 no 1480 0.474477469575696 513 716786
SGTC_66 0109-0187 42.4 µM 0.0615674507368999 0.451255412928849 no 1481 0.475453649148991 461 759417
SGTC_2959 9079155 11 µM 0.0611792570321915 0.451430268375857 no 1482 0.475608224636644 526 16189457
SGTC_1059 3448-6867 171 µM 0.0610429926508896 0.451491648653673 no 1483 0.475662484845699 517 3934407
SGTC_3281 9140613 49.47 µM 0.060430201899339 0.451767694504362 no 1484 0.475906502483872 515 16013766
SGTC_1661 st013063 9.66 µM 0.0601794669457291 0.451880650628741 no 1485 0.476006349537072 516 721395
SGTC_376 3970-0862 59.1 µM 0.0572092161736941 0.453219042845648 no 1486 0.477189268370535 526 3135186
SGTC_1634 st006576 41 µM 0.0571511356052357 0.453245219243654 no 1487 0.477212401316608 524 3915356
SGTC_718 1130-0073 349 µM 0.0563322044719603 0.453614325829276 no 1488 0.4775385820499 521 6740020
SGTC_720 r052-1644 49.9 µM 0.056331006150631 0.453614865963097 no 1489 0.477539059353041 515 1422863 YOR257W CDC31
SGTC_665 3914-0008 307 µM 0.0561378156552155 0.453701946165712 no 1490 0.477616009443494 502 1069549
SGTC_3137 9097352 49.47 µM 0.0555796462499689 0.45395355232272 no 1491 0.477838339688113 524 44120435
SGTC_2062 5245942 200 µM 0.0551207040586165 0.454160443653964 no 1492 0.478021150882294 519 1376160
SGTC_615 k087-0205 167 µM 0.0547338576912339 0.454334843821003 no 1493 0.478175247622477 520 9642773
SGTC_842 0271-0008 11.1 µM 0.0542139495450744 0.454569245478759 no 1494 0.478382353449948 517 1221709
SGTC_85 0868-0259 160.055 µM 0.0530178643655806 0.455108562878748 no 1495 0.478858837012798 523 83173
SGTC_882 0843-0131 351 µM 0.0520928319097731 0.455525718816753 no 1496 0.479227362260172 512 5425421
SGTC_1347 1493-0251 600 nM 0.0515699468405565 0.45576154265794 no 1497 0.479435683205308 524 3986378
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.0513457148013629 0.455862677234862 no 1498 0.479525020489374 525 688664
SGTC_1511 0906-3109 28.5 µM 0.0509472542801837 0.456042400514972 no 1499 0.479683775452889 524 2882180
SGTC_1002 4049-0206 172 µM 0.0505778948798131 0.456209005939143 no 1500 0.479830938803197 525 4662749
SGTC_2721 ifenprodil 61.44 µM 0.0502623424821987 0.456351346959985 no 1501 0.479956666082941 516 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1194 1488-0194 225 µM 0.0494381393686487 0.456723159174876 no 1502 0.480285067243602 519 1391452
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.0493639719146858 0.456756619253416 no 1503 0.480314619693951 510 2724 A muscle relaxant with antifungal properties.
SGTC_1121 fusaric acid 630.51 nM 0.0485366168859219 0.457129894867551 no 1504 0.480644291381414 505 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_573 3702-0553 84.7 µM 0.0484227648526038 0.457181264161115 no 1505 0.480689658427213 518 1222756
SGTC_1081 sertraline 6 µM 0.047864489499508 0.457433164692122 no 1506 0.480912120105514 542 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1218 1348-1416 30.7 µM 0.0473577267226005 0.457661836941761 no 1507 0.48111406019077 524 6787668
SGTC_1693 xanthone 101.9 µM 0.0472170511078597 0.457725318065374 no 1508 0.481170118929821 530 7020 An insecticide.
SGTC_3199 9111318 49.47 µM 0.0471907926204106 0.457737167561112 no 1509 0.48118058288624 516 8548020
SGTC_23 0213-0011 39.996 µM 0.0466674922052349 0.457973321734327 no 1510 0.481389119783313 522 627608
SGTC_3202 9113761 49.47 µM 0.0463717877128199 0.458106773350204 no 1511 0.481506961229428 535 4798415
SGTC_687 k029-0044 34.9 µM 0.0455827822089978 0.458462875081635 no 1512 0.481821396356631 527 5829338
SGTC_311 1315-0136 58 µM 0.0452855393155263 0.458597038331643 no 1513 0.481939856784094 521 6759207
SGTC_3061 glucosamine 200 µM 0.0451076346189987 0.458677339471697 no 1514 0.482010758036224 529 91431 and experimental redox chemotherapeutic
SGTC_1232 0279-0259 161 µM 0.0448205261070737 0.458806935675599 no 1515 0.4821251820324 521 1560000
SGTC_2907 7721985 69.9 µM 0.0432007499771409 0.459538158421564 no 1516 0.482770753626547 521 3267881
SGTC_3245 9134821 49.47 µM 0.0430296447941941 0.45961540923283 no 1517 0.482838951301851 529 17014901
SGTC_1996 st072960 66.8 µM 0.0424160323514233 0.459892456368642 no 1518 0.483083523941342 517 1719405
SGTC_297 0986-0032 24 µM 0.0411329612153171 0.460471828104206 no 1519 0.483594948790557 518 2847425
SGTC_1346 1488-2224 62.4 µM 0.0410812029736575 0.460495201346441 no 1520 0.483615579902999 527 3722427
SGTC_1304 1165-0502 251 µM 0.0404794160354161 0.460766969260965 no 1521 0.483855458606712 533 767425
SGTC_2888 9058547 12.99 µM 0.0401371044542819 0.460921565886846 no 1522 0.483991910273472 525 16476514
SGTC_2662 daunorubicin 22.37 µM 0.0389449809637634 0.461460005160387 no 1523 0.48446712706462 523 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2477 5967686 25.23 µM 0.0387439489116112 0.461550811091397 no 1524 0.484547266765896 521 776118
SGTC_1940 st075990 51.1 µM 0.0375052836109977 0.462110358732419 no 1525 0.485041063700044 532 1084979
SGTC_3259 9138485 49.47 µM 0.0374231897182538 0.462147446024268 no 1526 0.485073791448925 515 17646153
SGTC_454 lyso-paf C-16 6.67 µM 0.0361577340251251 0.462719178283763 no 1527 0.485578293648217 524 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_134 0269-0018 6.916 µM 0.0347021771747906 0.463376893333228 no 1528 0.486158612420037 527 4378915
SGTC_518 1021-0119 62.6 µM 0.0334586382834063 0.463938884285021 no 1529 0.486654424609051 511 1097762
SGTC_1872 amphotericin b 148 nM 0.0331208002639931 0.464091575469668 no 1530 0.486789127818187 531 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_191 3914-0123 66.505 µM 0.0327434416008988 0.464262134880452 no 1531 0.486939590530497 533 3144412
SGTC_1496 4469-0713 57.4 µM 0.0325941424059869 0.46432961727876 no 1532 0.486999120516557 536 746691
SGTC_1848 st056003 16.4 µM 0.0323522962806911 0.464438932546777 no 1533 0.487095552303507 533 146492
SGTC_2198 6589944 200 µM 0.0320117323508241 0.464592873146505 no 1534 0.487231347315216 532 5290268
SGTC_634 1611-4317 11.2 µM 0.0319456822830643 0.464622729497617 no 1535 0.487257684009972 522 2843522
SGTC_1831 st055328 12 µM 0.0314159049940219 0.464862209823941 no 1536 0.487468928530517 532 1103068
SGTC_2050 5263056 171 µM 0.0310585582475303 0.465023751906303 no 1537 0.487611419719805 527 763468 YGL055W OLE1
SGTC_1773 st048542 73.5835 µM 0.0310443955790534 0.465030154397669 no 1538 0.487617067083829 534 3237138
SGTC_1048 3161-0300 24.5 µM 0.0306139238575192 0.465224761265072 no 1539 0.487788718861249 526 2165101
SGTC_2409 alverine citrate 63.97 µM 0.0290281925687066 0.465941707156335 no 1540 0.488421052823093 492 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.028659614313806 0.466108365852187 no 1541 0.488568033117405 536 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2687 chenodiol 100 µM 0.0280069821264535 0.466403478747684 no 1542 0.488828291200462 533 5702181 A cholesterol synthesis inhibitor.
SGTC_2220 6782180 200 µM 0.028006607912088 0.466403647968503 no 1543 0.488828440431856 532 833803
SGTC_948 3448-0295 75.3 µM 0.0278627271108451 0.466468711733093 no 1544 0.488885818175156 528 678569
SGTC_1962 st076595 64.5 µM 0.0274482451415944 0.466656147978006 no 1545 0.489051109334403 532 279619
SGTC_3224 9130643 49.47 µM 0.0263774713920994 0.46714040536769 no 1546 0.489478131560908 527 17644395
SGTC_2592 piperlongumine 83.33 µM 0.0259703024325928 0.467324560318453 no 1547 0.48964051284201 532 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3040 9091894 49.47 µM 0.025297871028262 0.46762870383598 no 1548 0.489908686031181 531 25236966
SGTC_1966 st070145 16.1 µM 0.024288185192264 0.4680854243721 no 1549 0.490311368601633 535 3748532
SGTC_1258 0671-0043 57.1 µM 0.0242609591845576 0.468097740348445 no 1550 0.490322227007578 533 4298767
SGTC_1656 st012921 11 µM 0.0234926184512704 0.468445320058993 no 1551 0.490628663242046 535 6732821
SGTC_2375 9072683 200 µM 0.0232452510656326 0.468557228517486 no 1552 0.490727321608022 536 16798029
SGTC_3083 9117465 49.47 µM 0.0231056398396994 0.468620389424881 no 1553 0.490783003473412 532 16420915
SGTC_452 diindolylmethane 8 µM 0.0229244535176531 0.468702360318049 no 1554 0.490855267216496 541 3071 Inhibits expression of several cancer promoting factors.
SGTC_3056 9094900 49.47 µM 0.0224348793342355 0.468923856252248 no 1555 0.491050528831155 530 25236784
SGTC_2988 9073640 71.4286 µM 0.0220602693304774 0.469093345938435 no 1556 0.491199939619091 538 9102229
SGTC_1885 st057546 99.9 µM 0.0217444648113187 0.469236233845315 no 1557 0.491325897178196 530 702008
SGTC_1415 3966-0071 78.1 µM 0.0211076879389345 0.469524359911457 no 1558 0.491579876086884 540 2893185
SGTC_1439 4092-1168 46 µM 0.0208738797226525 0.469630156463327 no 1559 0.49167313152261 534 2886240
SGTC_1140 3229-1848 2.98 µM 0.0204913208145137 0.469803266264211 no 1560 0.491825717805476 541 2849525
SGTC_2332 7982454 138.89 µM 0.0202986242297322 0.469890464586923 no 1561 0.49190257663375 538 2981748
SGTC_2938 9059746 27.26 µM 0.0202557501063028 0.469909866018065 no 1562 0.491919677418342 538 6471769
SGTC_713 1488-1073 324 µM 0.0198770165294019 0.470081253923627 no 1563 0.492070739837834 542 3312542
SGTC_2598 perillyl alcohol 100 µM 0.019807696276526 0.470112623945479 no 1564 0.492098389174017 534 10819 An apoptosis inducer.
SGTC_3001 9076041 71.4286 µM 0.0195326650508812 0.470237087746211 no 1565 0.492208089533546 532 16004211
SGTC_2280 7785178 200 µM 0.0190157850701 0.470471006669241 no 1566 0.492414256510843 530 2954328
SGTC_2185 6113692 200 µM 0.0177226940385436 0.471056251700203 no 1567 0.492930038132641 534 874150
SGTC_1085 doxorubicin 7.67 µM 0.0174597815431678 0.471175251963532 no 1568 0.493034908815332 537 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_472 calcifediol 10 µM 0.0153992812272783 0.472107970253701 no 1569 0.49385681842843 541 5283731 A vitamin D metabolite.
SGTC_411 enrofloxacin 100 µM 0.0152518977139636 0.472174691671918 no 1570 0.493915609038683 539 71188 A bacterial gyrase inhibitor.
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.0149152244518994 0.472327108643692 no 1571 0.494049906958782 541 5379071
SGTC_2581 avocatin a 64 µM 0.0134573045528087 0.472987177057567 no 1572 0.494631474273283 540 6710728 A skin care supplement.
SGTC_1053 3366-3204 134 µM 0.0120381792793733 0.473629752596905 no 1573 0.495197577299409 535 3632071 YPR165W RHO1
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.0119176890064148 0.473684313404109 no 1574 0.495245642515537 542 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_3348 9149464 3.537 µM 0.0113465259478037 0.473942956064072 no 1575 0.495473488190567 543 1951442
SGTC_3289 9119912 71.43 µM 0.0102775897955205 0.474427037263975 no 1576 0.495899907071423 541 17014829
SGTC_950 1165-0508 94.1 µM 0.00976373014379114 0.474659758562016 no 1577 0.49610489711828 540 6148369
SGTC_1100 amiodarone 5.07 µM 0.00955973911091305 0.47475214622486 no 1578 0.496186273967659 544 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_3047 9092122 49.47 µM 0.00812136309647015 0.475403625850915 no 1579 0.496760080502011 543 17173831
SGTC_1913 st060213 96.1 µM 0.0074179290730887 0.475722254309574 no 1580 0.497040701599315 541 688959
SGTC_1824 st053723 68.6 µM 0.00737214391497584 0.475742993759155 no 1581 0.497058966735263 541 675225
SGTC_3193 9111931 49.47 µM 0.0067089000055107 0.476043432818185 no 1582 0.497323556210326 539 17087244
SGTC_402 epigallocatechin gallate 10 µM 0.0064927336950921 0.476141355708031 no 1583 0.497409792212277 542 65064 An antioxidant.
SGTC_2267 7931562 200 µM 0.00583440747185352 0.476439584971881 no 1584 0.497672421383645 543 934880
SGTC_1249 0481-0015 10.2 µM 0.00540861925392256 0.476632478914273 no 1585 0.497842283621027 546 4227577
SGTC_859 0439-0102 54.6 µM 0.00373678611180092 0.477389918505916 no 1586 0.498509241496572 543 610143
SGTC_458 nppb 133 µM 0.00358870123849527 0.477457013716613 no 1587 0.498568318417287 545 4549 A chloride channel blocker.
SGTC_2742 clothiapine 36.27 µM 0.00307070397874939 0.477691716134809 no 1588 0.498774968277463 545 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_373 0844-0104 25.9 µM 0.00306178153655824 0.477695758924521 no 1589 0.498778527800165 545 5375804
SGTC_2775 cyproheptadine 69.59 µM 0.00302523244088563 0.477712319471346 no 1590 0.498793108712207 544 2913 A selective serotonin reuptake inhibitor.
SGTC_285 1486-1325 46 µM 0.000885045136442577 0.47868211336792 no 1591 0.499646918121105 548 22310230
SGTC_2182 6325192 200 µM 0.000546475811674541 0.478835542709792 no 1592 0.499781987704357 547 736248
SGTC_2244 6635614 200 µM 0.000327185512530562 0.478934920092564 no 1593 0.499869471867846 548 836499
SGTC_3300 9124615 50.48 µM 0.00026557264627864 0.478962841880049 no 1594 0.499894051844127 547 24824903
SGTC_62 0180-0423 3.232 µM -0.00084828939564636 0.479467640793547 no 1595 0.499661581534648 549 30102 YGL099W LSG1
SGTC_2328 6201408 200 µM -0.000866155298459685 0.479475737837272 no 1596 0.499654454073257 550 2890418
SGTC_631 k072-0230 41.5 µM -0.0012265588943888 0.479639078919937 no 1597 0.49951067392032 549 5773147
SGTC_1000 4048-0884 8.67 µM -0.00287180747983856 0.480384776777419 no 1598 0.498854316149915 551 13040088
SGTC_96 0929-0093 37.281 µM -0.00318030373662112 0.480524608352824 no 1599 0.498731244513713 551 6991579
SGTC_3091 9116372 49.47 µM -0.00338697278277864 0.480618286222625 no 1600 0.49864879593779 549 17169793
SGTC_2351 9026858 72.31 µM -0.00416092726355828 0.480969109750072 no 1601 0.498340034978809 553 1409300
SGTC_2302 7771753 200 µM -0.00444055816043328 0.48109586644767 no 1602 0.498228479423195 549 2203047
SGTC_2966 9084041 48.03 µM -0.00453556654307104 0.481138934187275 no 1603 0.498190576944114 560 17741380
SGTC_784 4579-0127 173 µM -0.0046201606817849 0.481177281287188 no 1604 0.498156829119142 553 1948547
SGTC_1572 epiandrosterone 68.9 µM -0.00531236098610495 0.481491066916645 no 1605 0.497880684562156 551 441302 A steroid.
SGTC_2969 9091408 28.7 µM -0.00562797587488225 0.481634144084896 no 1606 0.497754774323025 555 4286311
SGTC_252 miconazole 1.30953 nM -0.00641090709501268 0.481989079155665 no 1607 0.497442435623287 556 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_69 0096-0274 206.684 µM -0.0081544700154308 0.482779559152042 no 1608 0.496746873189603 551 6741392
SGTC_1212 0520-0165 585 µM -0.0088393500852077 0.483090082264009 no 1609 0.496473655441099 556 5403258
SGTC_97 0535-0701 19.132 µM -0.0102250963927024 0.483718407758941 no 1610 0.495920847808887 552 2832013 YGL099W LSG1
SGTC_2621 lithochol-11-enic acid 100 µM -0.0104605716278472 0.48382518107088 no 1611 0.495826911806316 554 6708711
SGTC_1728 st035614 33.7865 µM -0.011155985377468 0.484140514514345 no 1612 0.495549498068865 566 15945546
SGTC_483 fpl-64176 144 µM -0.011351842479391 0.484229327174856 no 1613 0.495471367337923 553 3423
SGTC_2732 terfenadine 20 µM -0.0118517327434424 0.484456009161619 no 1614 0.495271953399265 554 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2639 lactacystin 53 µM -0.0118919220623455 0.484474233769826 no 1615 0.495255921310559 556 3870 A proteasome inhibitor.
SGTC_2883 9059145 45.46 µM -0.014174746139428 0.485509475686449 no 1616 0.494345283812486 548 16476510
SGTC_1391 3442-0225 151 µM -0.014635706922342 0.485718529682412 no 1617 0.49416140614747 555 5227075
SGTC_863 0466-0191 129 µM -0.0146443652331101 0.485722456419622 no 1618 0.494157952351375 558 765160 YPR165W RHO1
SGTC_1834 st055981 52.8 µM -0.0151575315764257 0.485955191270971 no 1619 0.493953251329385 554 471719 YDL150W RPC53
SGTC_190 3970-0790 3.722 µM -0.015160170271367 0.485956388003107 no 1620 0.493952198763349 556 2832352
SGTC_2334 9017922 200 µM -0.0151766516470532 0.485963862834381 no 1621 0.493945624402109 559 3163164
SGTC_1811 st050069 61.5 µM -0.0165048775800145 0.486566271782407 no 1622 0.493415805436326 552 3877702
SGTC_2511 berberine 10.47 µM -0.0168422501780251 0.48671929004816 no 1623 0.493281231950904 556 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1579 chlormadinone acetate 49.4 µM -0.0169105672295025 0.486750276077734 no 1624 0.493253981271555 560 45114258 A steroidal progestin.
SGTC_3026 9090633 49.47 µM -0.0171884870048999 0.486876330794574 no 1625 0.493143123436548 561 25236842
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.0174927695428439 0.487014344244242 no 1626 0.493021750517075 550 688803
SGTC_2215 7188065 200 µM -0.0177403796439407 0.487126653921683 no 1627 0.492922983705963 555 940217
SGTC_2000 st075254 36.4 µM -0.0178737836913291 0.487187163046296 no 1628 0.492869771628357 564 17234175
SGTC_193 1273-0060 1.558 µM -0.0180214803621642 0.487254155332711 no 1629 0.492810858670952 563 2847393 YHR072W ERG7
SGTC_2830 7992007 71.43 µM -0.0195492485590482 0.487947141502977 no 1630 0.492201474933991 554 1952075
SGTC_2084 5306078 60.6385 µM -0.0198172113676824 0.488068691580066 no 1631 0.492094593946803 563 679340
SGTC_170 4197-0004 226 µM -0.0205947765077636 0.488421407591331 no 1632 0.491784453663309 561 218692
SGTC_1247 0448-0043 5.84 µM -0.0212059188028026 0.48869863790237 no 1633 0.491540696411658 564 3089013 YGL099W LSG1
SGTC_2982 9019404 25.97 µM -0.0221812012262112 0.489141063062987 no 1634 0.49115170657517 560 22333232
SGTC_2628 lathosterol 100 µM -0.0228223181944453 0.489431905390197 no 1635 0.490896002657611 562 6710616
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.0234521867900735 0.489717650373364 no 1636 0.490644788698361 558 91467 include heat shock
SGTC_2749 bexarotene 57.39 µM -0.0238273239238002 0.489887836885408 no 1637 0.490495172447113 561 82146 An retinoic acid receptor inhibitor.
SGTC_1749 st037932 54.2 µM -0.0242402785323268 0.490075181982116 no 1638 0.4903304749685 562 594497
SGTC_2783 7738165 71.43 µM -0.0245107787693418 0.490197901000661 no 1639 0.490222593042094 558 17201110
SGTC_923 1900-2434 73.3 µM -0.0250415083954375 0.490438682102982 no 1640 0.490010927533445 557 5910570
SGTC_2475 5812728 15.03 µM -0.0251166915196596 0.490472791422018 no 1641 0.48998094323739 558 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1328 1441-0025 69.2 µM -0.0263680933348203 0.491040541419638 no 1642 0.489481871563608 563 4562601
SGTC_3162 9099653 49.47 µM -0.0264782492393059 0.491090519070709 no 1643 0.489437941054361 552 25237511
SGTC_1144 3486-0183 12.5 µM -0.026862317806955 0.491264771780097 no 1644 0.489284774348829 575 6744069
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.0273843296747132 0.491501612318516 no 1645 0.489076598335269 559 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1787 fluconazole 80 µM -0.0276271904380764 0.491611801019669 no 1646 0.488979747552726 559 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3067 9117431 49.47 µM -0.0278182000192842 0.491698464697598 no 1647 0.488903575031674 560 17150885
SGTC_850 0388-0143 75.9 µM -0.0287879176025843 0.492138444880848 no 1648 0.488516868621941 564 67273
SGTC_234 nsc-17383 10.7 µM -0.0289832757746568 0.492227083949632 no 1649 0.488438964494916 562 408974
SGTC_2094 5332512 191.667 µM -0.0295370382675451 0.492478342424497 no 1650 0.48821813977655 565 755774
SGTC_2056 5235370 200 µM -0.030913886680734 0.493103072125293 no 1651 0.487669107623468 568 5511916
SGTC_3270 9137563 49.47 µM -0.0330164219567997 0.494057106315097 no 1652 0.486830745976426 557 17015724
SGTC_2180 6301957 200 µM -0.0333047963424247 0.494187960173934 no 1653 0.486715764477519 576 845462
SGTC_2659 sanguinarine 24.21 µM -0.0336291863690138 0.494335157373814 no 1654 0.486586424034628 564 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2217 6934799 96.0675 µM -0.0336676795871291 0.494352624343171 no 1655 0.48657107615344 572 675606
SGTC_1126 isoteolin 1.0172 µM -0.034595849476986 0.494773800825606 no 1656 0.486201005578969 566 133323
SGTC_1466 k213-0079 57.5 µM -0.0346858196213514 0.49481462697585 no 1657 0.486165134213471 560 3657981
SGTC_3185 9108267 49.47 µM -0.0347211998001311 0.494830681610922 no 1658 0.486151028061083 573 4910486
SGTC_2427 5545055 42.75 µM -0.0354203088812386 0.495147921408412 no 1659 0.485872295363138 573 5372858
SGTC_1164 k060-0068 93.7 µM -0.035791455067172 0.495316340364336 no 1660 0.485724323285877 563 5963676
SGTC_265 mycophenolic acid 32.932 µM -0.0361459294070525 0.495477194739018 no 1661 0.485582999933014 558 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_342 k048-0088 23.3 µM -0.0369292421346842 0.495832651188133 no 1662 0.485270711896261 562 6820570
SGTC_237 nikkomycin 200 µM -0.0370216902463212 0.495874603082449 no 1663 0.485233855639075 580 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_24 0417-1663 219 µM -0.0373157866088486 0.496008060944855 no 1664 0.485116609182827 578 4329390
SGTC_770 0389-1121 67.2 µM -0.0382824224386079 0.49644671327133 no 1665 0.484731252687277 568 6753108
SGTC_2968 9090663 33.37 µM -0.0387111274129105 0.496641257885033 no 1666 0.484560350833865 572 25236811
SGTC_1120 ficusin 1.78878 µM -0.0388865863952547 0.496720880706946 no 1667 0.484490405493394 580 6199 A DNA cross-linker.
SGTC_58 0957-0393 9 µM -0.0390456409866514 0.496793059372619 no 1668 0.484427000046421 560 6997992
SGTC_2874 9043904 71.43 µM -0.0413248064869447 0.497827350641685 no 1669 0.483518478620948 577 4463428
SGTC_119 0121-0043 24.815 µM -0.0416591930701881 0.497979097543137 no 1670 0.483385192456709 569 1092378
SGTC_2504 purpurogallin 52.29 µM -0.0426364204151512 0.498422571541422 no 1671 0.48299568129156 568 5281571 An antioxidant.
SGTC_1077 5-fluorocytosine 377 nM -0.0428769834383511 0.498531741387218 no 1672 0.482899798214435 571 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_566 0958-0068 16.5 µM -0.0431875681434835 0.498672687916535 no 1673 0.482776007513858 581 6815365
SGTC_1424 4048-1941 275 µM -0.0434771714509834 0.498804113021724 no 1674 0.48266058092916 560 X1424
SGTC_2804 7954240 19.48 µM -0.0437968762304402 0.49894919864977 no 1675 0.4825331585519 574 828705
SGTC_2808 7946468 45.46 µM -0.0446320692557123 0.499328219254071 no 1676 0.482200290275914 582 2970879
SGTC_1764 st044502 93.5 µM -0.0459220265072664 0.499913618383905 no 1677 0.48168619904048 570 8407
SGTC_1485 3909-9022 254 µM -0.0461123727633031 0.5 no 1678 0.481610342230213 562 714516
SGTC_211 3455-0679 143.504 µM -0.0464134369516304 0.499863373142334 no 1679 0.481490363458215 572 748649
SGTC_917 harmaline 728.087 nM -0.0466546296266517 0.499753916769547 no 1680 0.481394245626574 574 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_3240 9133527 49.47 µM -0.0474013433737796 0.499415048513569 no 1681 0.481096679184057 598 17617455
SGTC_997 3996-0078 137 µM -0.0475943512534396 0.499327459126197 no 1682 0.481019766988187 574 735687
SGTC_647 0140-0236 81 µM -0.0479467527912086 0.499167534991826 no 1683 0.480879339436902 580 990837
SGTC_3315 9136395 68.55 µM -0.0479565493535605 0.499163089193626 no 1684 0.480875435664649 566 16876844
SGTC_148 3253-0744 288.01 µM -0.0481927999249186 0.499055875866516 no 1685 0.480781294174763 567 6893655
SGTC_2778 tioconazole 65.09 nM -0.0482753389684797 0.499018418679759 no 1686 0.480748404142522 585 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_415 dibenzyl ketone 100 µM -0.0483314669355848 0.498992947154416 no 1687 0.480726038430609 570 7593
SGTC_2127 5253358 187.912 µM -0.0486826117713636 0.498833593634539 no 1688 0.480586116619972 578 20612
SGTC_2557 derrustone 83.84 µM -0.0488840456146237 0.498742180748027 no 1689 0.48050585170792 566 629853 An antioxidant.
SGTC_1888 azatryptophan 97.5 µM -0.0502173341877825 0.498137121667783 no 1690 0.479974599148365 577 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_111 0083-0039 52.457 µM -0.0509209562938755 0.497817812879319 no 1691 0.479694253231536 561 759313
SGTC_1722 st034304 3.6505 µM -0.0515749681429189 0.497521018832739 no 1692 0.47943368265771 570 4036148 YLR033W RSC58
SGTC_1711 st032263 62.8 µM -0.0519712108134631 0.497341202463773 no 1693 0.479275816422501 575 3958979
SGTC_1072 oxiconazole 14.9 nM -0.0528197152711932 0.496956149910002 no 1694 0.478937776455883 569 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2112 5488546 200 µM -0.0534452884971078 0.496672265668504 no 1695 0.478688560874637 584 600757
SGTC_2166 5933061 31.504 µM -0.0536130393532979 0.49659614084876 no 1696 0.478621733776452 571 2877375
SGTC_1564 D-Arginine 115 µM -0.0542681085003504 0.496298873708448 no 1697 0.47836077891329 597 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2974 9094440 9.66 µM -0.0542750959436537 0.496295702852007 no 1698 0.478357995428991 579 25236134
SGTC_1452 4194-0072 190 µM -0.0542837567200194 0.496291772648202 no 1699 0.478354545365249 602 1343545
SGTC_2282 7944268 200 µM -0.0548024551975094 0.496056391333431 no 1700 0.47814792218966 590 2970414
SGTC_2049 5262831 67.185 µM -0.054980190708282 0.495975736659569 no 1701 0.47807712272159 580 763417
SGTC_503 tyrphostin 8 294 µM -0.0550050796727153 0.495964442298751 no 1702 0.478067208464001 574 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_3129 9127257 49.47 µM -0.0550883720522178 0.495926645081307 no 1703 0.478034029918144 614 837894
SGTC_2221 6807166 181.081 µM -0.0552128607594625 0.495870153466123 no 1704 0.477984441580505 567 674925
SGTC_2394 5221648 200 µM -0.0562268552998429 0.495410017007583 no 1705 0.477580543781704 581 788586
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.057833294196876 0.494681050378619 no 1706 0.476940708809034 579 6728940
SGTC_2081 5214970 32.255 µM -0.058235686834421 0.494498456138938 no 1707 0.476780447481285 583 2063512
SGTC_198 3454-2873 16.191 µM -0.0594886914842307 0.493929886116057 no 1708 0.476281436207237 575 710957
SGTC_546 peri-Naphthalide 147 µM -0.060066858209909 0.493667538209753 no 1709 0.476051192800027 574 223824 A penicillin ester.
SGTC_591 4299-0174 154 µM -0.0602316341500292 0.493592770268466 no 1710 0.475985575517647 578 5509088
SGTC_2674 ligustilide 100 µM -0.0604637430968232 0.493487450007063 no 1711 0.475893145905741 574 5319022 A signalling regulator.
SGTC_1714 st033236 13.627 µM -0.0613639619477026 0.493078976858172 no 1712 0.475534676224307 595 2916566
SGTC_1400 3771-8998 51.5 µM -0.0618239725666861 0.492870250404538 no 1713 0.475351506326845 577 670767
SGTC_2356 9061756 188.97 µM -0.0622755241516233 0.492665364073954 no 1714 0.475171709766504 584 20104043
SGTC_771 0250-0039 27.3 µM -0.0626577478333149 0.492491935990938 no 1715 0.475019521794943 601 3005115
SGTC_2506 ethyl hematommate 54.16 µM -0.0627734718732455 0.492439428276323 no 1716 0.474973445286902 590 3940691 An allergen.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.0640067128690182 0.491879875536673 no 1717 0.474482440837023 575 368090
SGTC_346 4513-0042 7.16 µM -0.0640265879112479 0.491870857853455 no 1718 0.474474528072751 584 2827372
SGTC_2381 9035592 200 µM -0.0654105645425924 0.49124293191117 no 1719 0.473923556403185 602 4749657
SGTC_782 0083-0095 30.5 µM -0.066867141184151 0.490582089986148 no 1720 0.473343736003292 617 3591729 An indicator and reagent.
SGTC_685 1278-0033 54.9 µM -0.0676660852647408 0.490219623702535 no 1721 0.473025723723331 576 3590572
SGTC_2567 aureobasidin a 60 nM -0.0677683492587658 0.490173228979878 no 1722 0.472985019726004 574 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_351 caspofungin 25 nM -0.0689697131450368 0.489628209106919 no 1723 0.47250686374135 574 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1679 SEC14.276 6.7 µM -0.0706283951182788 0.488875750873371 no 1724 0.471846755401598 605 1005053 YMR079W SEC14
SGTC_1993 st073995 70.8 µM -0.0708371377119068 0.488781057903272 no 1725 0.471763687215786 576 3098394
SGTC_231 b-estradiol 524 µM -0.071085403567154 0.488668436617698 no 1726 0.471664892523429 586 450 A steroid.
SGTC_2249 haloperidol 116.36 µM -0.0713287078103316 0.488558066953676 no 1727 0.471568073942104 578 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2164 5685496 200 µM -0.0722298561087243 0.488149288379063 no 1728 0.471209492740687 586 759046
SGTC_1300 1094-0077 113 µM -0.0723472383623698 0.488096042389658 no 1729 0.471162786191999 576 5532636
SGTC_537 1334-0398 209 µM -0.0724823821252483 0.488034739830779 no 1730 0.471109012807346 604 5846986
SGTC_3255 9139072 49.47 µM -0.0726669320567718 0.487951026597877 no 1731 0.47103558167564 576 17646060
SGTC_3143 9086658 49.47 µM -0.0732141422224879 0.487702811097951 no 1732 0.470817856362407 596 25236626
SGTC_2016 5121758 140 µM -0.0741470653808337 0.487279646536716 no 1733 0.47044668277167 589 2795203
SGTC_1669 st015249 58.4 µM -0.0748143953287557 0.486976961142536 no 1734 0.470181194050876 591 722793
SGTC_1032 k061-1018 98.7 µM -0.0760919924448264 0.48639749378592 no 1735 0.469672955387761 614 4005393
SGTC_317 4495-0002 170 µM -0.076876106218892 0.486041865035819 no 1736 0.469361052879259 597 15991618
SGTC_2108 5365811 200 µM -0.0769868571122399 0.485991635711105 no 1737 0.469317000220201 569 780283
SGTC_843 0310-0051 143 µM -0.0793638050392716 0.484913663266543 no 1738 0.468371628597491 581 2065037
SGTC_1985 st071382 65.5 µM -0.0799262983248288 0.484658582114364 no 1739 0.468147936848448 618 6123237
SGTC_1616 st002734 56.1 µM -0.0799426672978678 0.484651159156584 no 1740 0.468141427402394 579 4026101
SGTC_3272 9137413 49.47 µM -0.0801082341524457 0.484576078645004 no 1741 0.468075586945376 621 17614870
SGTC_2957 9076800 11.52 µM -0.0801689245084635 0.4845485571925 no 1742 0.46805145261855 593 16459615
SGTC_568 1193-0097 7.48 µM -0.0804043229413541 0.48444181099959 no 1743 0.467957844414373 589 3646150
SGTC_1261 0712-0010 12.7 µM -0.0805339551652187 0.484383027114535 no 1744 0.467906295805771 584 2840123
SGTC_2851 9015922 71.43 µM -0.08279769163564 0.483356554057129 no 1745 0.467006202317397 580 2996893
SGTC_2213 7173844 200 µM -0.0832230553486029 0.483163688414639 no 1746 0.466837090405489 585 892728
SGTC_2975 9084847 53.72 µM -0.0833931266676023 0.483086576885516 no 1747 0.466769476800558 575 27211724
SGTC_2654 protoveratrine a 100 µM -0.0838877872061533 0.482862297933676 no 1748 0.46657282486524 594 5702278 A heart drug and vasodilator.
SGTC_2192 5915882 198.485 µM -0.0850175131869804 0.482350100934433 no 1749 0.466123733803905 586 2876149
SGTC_3225 9130819 49.47 µM -0.0850568985877696 0.482332244838061 no 1750 0.466108078010833 599 4547121
SGTC_941 3237-0776 460 µM -0.0851527703636914 0.482288779752042 no 1751 0.466069968964855 586 760008
SGTC_54 0159-0055 9 µM -0.0851617118339835 0.482284725996456 no 1752 0.466066414744866 598 3319099
SGTC_2399 5884133 200 µM -0.0855143791484503 0.482124840211443 no 1753 0.465926232218774 593 722445
SGTC_484 loperamide 105 µM -0.0856805314991981 0.482049514126105 no 1754 0.4658601894102 576 3955 An opioid-receptor agonist.
SGTC_391 gliotoxin 8.33 µM -0.0869387291323454 0.481479124274554 no 1755 0.465360107327087 599 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1320 1313-0481 95.3 µM -0.0882783204367077 0.480871877208933 no 1756 0.464827734729569 573 6813365 YLR208W SEC13
SGTC_3166 9102297 49.47 µM -0.0890114387894198 0.480539567709154 no 1757 0.464536409683806 595 25237072
SGTC_2010 4012422 159 µM -0.0893149172714067 0.480402010259763 no 1758 0.464415819590572 598 952393
SGTC_3044 9093193 49.47 µM -0.0901391809160331 0.480028408759623 no 1759 0.464088307031435 610 25236277
SGTC_272 doxorubicin 8.13 µM -0.0903777296407015 0.479920288650434 no 1760 0.463993526714936 591 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1407 3909-7909 12.3 µM -0.0907139038507835 0.479767923159289 no 1761 0.463859961254548 581 4411780
SGTC_626 0214-0009 33 µM -0.0910784908615999 0.479602683370708 no 1762 0.463715111701627 605 3437874
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.0912175704923755 0.479539649987959 no 1763 0.463659856961182 588 688761
SGTC_1698 5-fluorocytosine 1.055 µM -0.0913058575140979 0.479499636991882 no 1764 0.463624781904791 585 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_828 2074-0507 139 µM -0.091459933467087 0.479429807965246 no 1765 0.463563570609806 586 X828
SGTC_2571 chrysanthemic acid 100 µM -0.0916734638726772 0.479333034528494 no 1766 0.463478740676108 621 2743 An insecticide.
SGTC_2718 lomofungin 53.02 µM -0.0929337680783042 0.47876188106794 no 1767 0.462978089388382 602 5351222 A RNA synthesis inhibitor.
SGTC_1007 4101-0031 70 µM -0.0937553708653979 0.478389564788385 no 1768 0.462651742175271 632 1146276
SGTC_2264 7948757 110.76 µM -0.094634276917773 0.477991301932699 no 1769 0.462302661479893 585 2971411
SGTC_2407 paclitaxel 400 µM -0.0951474960844727 0.477758754642707 no 1770 0.462098836375398 684 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_528 3492-0019 172 µM -0.0953179553246413 0.477681518679704 no 1771 0.46203114065003 578 2869262
SGTC_708 3448-5400 146 µM -0.0961342412256693 0.477311666987207 no 1772 0.461706978336237 582 3462195
SGTC_699 0375-0592 111 µM -0.096257334241891 0.477255896352626 no 1773 0.461658098011891 584 762578
SGTC_1435 4092-0789 56.7 µM -0.0971456069583977 0.476853453542707 no 1774 0.461305381498513 582 2248285
SGTC_3200 9114385 49.47 µM -0.0979674949347856 0.476481108167264 no 1775 0.460979052228415 604 17018030 YLR208W SEC13
SGTC_2790 5423970 71.43 µM -0.0981689341201943 0.476389851954197 no 1776 0.460899075131572 600 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_292 k038-0015 474 µM -0.0987263799852316 0.476137323652145 no 1777 0.460677761492018 605 46368540
SGTC_2338 7999974 200 µM -0.0990443431393144 0.475993287591727 no 1778 0.460551531217607 604 315925
SGTC_2113 5491891 107.031 µM -0.0991063692082423 0.475965190391084 no 1779 0.460526907545358 612 789979
SGTC_3045 9092950 49.47 µM -0.100095027854849 0.475517353952104 no 1780 0.460134441353193 615 44120432
SGTC_2406 ethylparaben 405.7 µM -0.100150563121537 0.475492198844877 no 1781 0.460112396758475 647 8434 A possible steroid mimic.
SGTC_154 3389-1638 511.116 µM -0.101700268226209 0.474790288284998 no 1782 0.459497294618827 662 5238686
SGTC_1341 1486-1360 280 µM -0.102045277132038 0.474634033387825 no 1783 0.459360368341173 595 3976547
SGTC_515 4092-1064 102 µM -0.102329284253589 0.474505409189928 no 1784 0.459247655916892 646 717353
SGTC_2791 5663188 71.43 µM -0.10315605099147 0.474130989359088 no 1785 0.458919559995863 600 54690634
SGTC_2764 methyldopa 94.69 µM -0.103232856605449 0.474096207371771 no 1786 0.458889081705004 610 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_552 k242-0005 476 µM -0.104464029366912 0.473538688861331 no 1787 0.458400556232977 594 4088318
SGTC_302 1094-0063 18.9 µM -0.104871863975038 0.473354018320127 no 1788 0.458238742562602 599 5440289
SGTC_2021 4019055 173 µM -0.105057456382828 0.473269982592254 no 1789 0.458165108657365 612 44827708 YER133W GLC7
SGTC_2709 st078560 56 µM -0.107039545630597 0.472372573018909 no 1790 0.457378803541143 619 17250903
SGTC_1446 4239-0190 62 µM -0.107629556344157 0.472105466989575 no 1791 0.457144775300437 626 1340085
SGTC_34 0469-0683 81.75 µM -0.107786520367297 0.472034409307991 no 1792 0.457082517889334 590 3690923
SGTC_2261 9010538 184.68 µM -0.107972688228437 0.47195013219035 no 1793 0.457008678582198 671 6457250
SGTC_2270 7924575 90.91 µM -0.108711886126921 0.471615513992733 no 1794 0.456715506984265 624 1262135
SGTC_3242 9133940 49.47 µM -0.109183700226531 0.471401944863908 no 1795 0.456528394174066 623 17248444
SGTC_2767 sibutramine 71.45 µM -0.110012204440907 0.471026938018995 no 1796 0.456199847961167 630 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1581 himbacine 57.9 µM -0.110069285900107 0.471001102112579 no 1797 0.45617721321107 632 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2730 imipramine 71.33 µM -0.110608870827452 0.470756884098092 no 1798 0.455963256375949 610 3696 A tricyclic antidepressant.
SGTC_3141 9094609 49.47 µM -0.110871954254053 0.470637815606896 no 1799 0.455858942860324 616 25236309 YDL196W YDL196W
SGTC_1789 tunicamycin 25 nM -0.111724503359474 0.470251979913636 no 1800 0.455520925046341 596 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2386 9075165 157.42 µM -0.112479182293972 0.469910460332333 no 1801 0.455221737554985 592 16452277
SGTC_114 0364-0001 490.298 µM -0.113093565399659 0.469632446032947 no 1802 0.45497818816577 603 4003655
SGTC_79 0052-0007 94.094 µM -0.11386377776529 0.469283938414456 no 1803 0.454672889962594 587 2801472
SGTC_622 1348-1566 26.3 µM -0.114494448426492 0.468998588486813 no 1804 0.454422923487247 611 7340407
SGTC_1030 k029-0042 36.7 µM -0.116105457088879 0.468269752621165 no 1805 0.453784481967813 593 6080581
SGTC_1250 0485-0349 40.2 µM -0.116395786555801 0.468138416006494 no 1806 0.453669437269855 627 6842794 YDL195W SEC31
SGTC_1075 aripiprazole 15.2 µM -0.116655552067016 0.4680209085763 no 1807 0.453566507007711 601 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2286 7945697 125 µM -0.117915923970179 0.467450806952624 no 1808 0.453067137885091 614 1245733
SGTC_3264 9137442 49.47 µM -0.1182435393297 0.467302628205427 no 1809 0.452937346259197 610 17015726
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.11830215115067 0.467276118856582 no 1810 0.452914126499367 595 688669
SGTC_1863 st057641 20.1 µM -0.118457785963006 0.467205728000943 no 1811 0.452852470725938 595 3921635
SGTC_826 1683-5028 118 µM -0.118487576326518 0.467192254466607 no 1812 0.452840669203447 620 722377
SGTC_820 1582-0060 59.9 µM -0.119320912387098 0.466815369956685 no 1813 0.452510558083965 612 3848840
SGTC_751 0833-0568 350 µM -0.121421158855269 0.465865645367244 no 1814 0.451678729263368 594 6954252
SGTC_1914 st062367 72.6 µM -0.121569621401934 0.46579851838073 no 1815 0.451619936803309 622 978205
SGTC_1929 genistein trimethyl ether 50.5 µM -0.122385277784362 0.465429738701671 no 1816 0.451296948743277 594 136420
SGTC_291 SEC14.278 35.5 µM -0.12344514658214 0.464950588570534 no 1817 0.450877304316511 601 1068044
SGTC_1461 k072-0203 53.8 µM -0.12345017723242 0.464948314412732 no 1818 0.450875312611502 602 5418714
SGTC_1754 st042065 16.137 µM -0.1237202849904 0.46482621107325 no 1819 0.450768374978848 608 1126236 YIL048W NEO1
SGTC_1203 3992-3522 103 µM -0.123772236090009 0.464802726741237 no 1820 0.45074780756889 643 5322312
SGTC_1029 k015-0030 64.7 µM -0.125119041941119 0.464193950395396 no 1821 0.450214654233963 612 2208316
SGTC_2544 sphondin 68.51 µM -0.125958427126461 0.463814578071188 no 1822 0.449882416375813 592 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_90 0870-0863 4.608 µM -0.126902351996828 0.463387996836514 no 1823 0.449508842534851 638 1738164
SGTC_2225 6654152 15.4 µM -0.12840672759866 0.462708222300503 no 1824 0.448913553689656 622 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2945 9067681 61.76 µM -0.129058348383328 0.462413811419835 no 1825 0.448655739742341 612 16456930
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.129453230075878 0.462235408662743 no 1826 0.448499515232484 631 5282309
SGTC_3174 9107204 49.47 µM -0.130381552613488 0.46181603379157 no 1827 0.448132280441229 628 3938802
SGTC_1515 3460-0031 42.1 µM -0.130535398357383 0.461746537208861 no 1828 0.448071424941547 598 2876596
SGTC_2317 5986382 200 µM -0.130768069902222 0.461641434946255 no 1829 0.447979391288239 612 877883
SGTC_459 nigericin 15.3 µM -0.130981223241485 0.461545151787734 no 1830 0.447895080554251 644 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2240 6690706 185.951 µM -0.131787324194861 0.461181049623865 no 1831 0.447576256462717 597 805876
SGTC_794 k038-0031 316 µM -0.132028838517819 0.461071968010655 no 1832 0.447480740787435 595 6624242
SGTC_444 curcumin 90.4 µM -0.133232697467965 0.460528280642422 no 1833 0.447004676256075 617 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2737 bleomycin 30.5 nM -0.133426021871679 0.460440978229833 no 1834 0.446928233457331 596 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1530 rhein 70.4 µM -0.13389049660514 0.460231236181393 no 1835 0.446744582615806 596 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2337 9009472 200 µM -0.133915404342826 0.46021998894964 no 1836 0.446734734550972 598 5742383
SGTC_1114 scopoletin 1.73284 µM -0.134952403825614 0.459751754243397 no 1837 0.446324753109084 597 5280460 A coumarin with genotoxic properties.
SGTC_1389 3405-0187 19 µM -0.135874803280076 0.459335311587806 no 1838 0.445960127394668 610 799890
SGTC_2453 5731132 22.18 µM -0.136696730402009 0.458964267511943 no 1839 0.445635257016709 632 1362040
SGTC_2078 5212016 200 µM -0.138045703426917 0.458355375757901 no 1840 0.445102148592274 608 1899708
SGTC_912 3474-0017 2.18 µM -0.138291191933767 0.45824457902162 no 1841 0.445005143222524 621 3360550
SGTC_400 oxethazaine 37.5 µM -0.138802854486585 0.458013659947943 no 1842 0.444802969134428 627 4621 A local anesthetic.
SGTC_2142 5622915 118.518 µM -0.138827516916881 0.458002529872707 no 1843 0.444793224589012 595 5322196
SGTC_3106 9121286 49.47 µM -0.13948381357367 0.457706357434444 no 1844 0.444533922899796 599 15943471
SGTC_3117 9124945 49.47 µM -0.139728952413346 0.457595737611454 no 1845 0.444437075045388 613 17592065
SGTC_1464 k208-0027 110 µM -0.140008718625016 0.45746949607088 no 1846 0.444326550888205 601 X1464
SGTC_1625 st003711 30.1 µM -0.141098555321216 0.45697775983573 no 1847 0.443896042460663 621 24207034 YER133W GLC7
SGTC_2287 7945887 168.79 µM -0.141188513480784 0.456937173488372 no 1848 0.443860510045382 622 1245853
SGTC_1688 st021091 57.6 µM -0.141789115671589 0.456666211833031 no 1849 0.443623290820526 634 3656366
SGTC_1200 1643-0193 18.4 µM -0.144385936614957 0.4554948896339 no 1850 0.442597860700039 629 5403974
SGTC_2470 5664817 21.68 µM -0.145007064263056 0.45521478069743 no 1851 0.442352647134788 611 2859561
SGTC_306 1672-3436 11.6 µM -0.14533695508426 0.455066019408022 no 1852 0.442222419264934 614 6797378
SGTC_2326 6164455 177.58 µM -0.145738294716252 0.454885047419759 no 1853 0.442063994645741 620 2888790
SGTC_488 nitrendipine 139 µM -0.146454969857949 0.45456190771757 no 1854 0.441781117697596 601 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_380 3970-0968 6 µM -0.146869714993669 0.454374918135055 no 1855 0.441617428296035 606 2891601
SGTC_3307 9126885 69.2785 µM -0.147542455953622 0.454071631573992 no 1856 0.441351935691719 622 24824909
SGTC_2022 5136654 200 µM -0.147596571922541 0.45404723605505 no 1857 0.4413305803394 625 1713771
SGTC_1269 0831-0796 3.05 µM -0.148355478951996 0.453705138507979 no 1858 0.441031116920261 603 927758
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.148415914858488 0.453677896887409 no 1859 0.44100727046176 606 94937 An inhibitor of serotonin biosynthesis.
SGTC_1413 3910-0535 34.4 µM -0.148927949527767 0.453447104868536 no 1860 0.440805243306452 607 2876951
SGTC_2792 7535235 81.82 µM -0.14917426261263 0.453336088501213 no 1861 0.440708064098595 609 1281891
SGTC_1803 st050068 52.4 µM -0.149319245654506 0.453270744547519 no 1862 0.440650864839117 619 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_580 1123-0028 41 µM -0.150448245464242 0.452761947002401 no 1863 0.440205490009256 617 1677248 YPR107C YTH1
SGTC_1394 3474-0001 65.7 µM -0.150554557518573 0.452714040159556 no 1864 0.440163555260527 613 5017666 YIL048W NEO1
SGTC_2017 5132927 60.65 µM -0.150990758595347 0.452517484372017 no 1865 0.439991502946114 631 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_89 0302-0250 142.109 µM -0.151270040606503 0.452391643710834 no 1866 0.439881350714946 603 4203518 YLR208W SEC13
SGTC_1265 0819-1001 68.8 µM -0.151754533160717 0.452173349331985 no 1867 0.4396902719865 627 3106768
SGTC_1106 tegaserod maleate 11.7 µM -0.154796246342581 0.450803199091277 no 1868 0.438490975263109 616 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2474 5321570 43.32 µM -0.155130445240334 0.450652693476884 no 1869 0.438359240443319 617 2841384
SGTC_3252 9135871 49.47 µM -0.155592226926089 0.450444742962001 no 1870 0.438177226167332 639 17682838
SGTC_3032 9089427 49.47 µM -0.156095537862442 0.450218106401835 no 1871 0.437978857760681 601 17173707
SGTC_1992 st073643 23.3 µM -0.156384990824117 0.450087775585165 no 1872 0.437864783601522 609 3161292
SGTC_896 0964-0007 44.5 µM -0.157500694763596 0.449585462561979 no 1873 0.437425130192915 609 6756758
SGTC_743 1275-0778 158 µM -0.157697270498127 0.449496968441282 no 1874 0.437347675704309 637 2849257 YMR203W TOM40
SGTC_3306 9127676 59.7925 µM -0.157808281403365 0.44944699485539 no 1875 0.437303936407478 613 41905287
SGTC_1253 0550-0034 176 µM -0.158520984807043 0.449126177537466 no 1876 0.43702314311889 609 5969915
SGTC_255 tunicamycin 200.472 nM -0.158996734316263 0.448912041477172 no 1877 0.436835723370643 622 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2461 5755302 26.15 µM -0.159091416283284 0.448869426657234 no 1878 0.43679842545227 658 2788904
SGTC_2118 5526350 200 µM -0.159392692738636 0.448733830931046 no 1879 0.43667974783163 632 743594
SGTC_2795 7780010 54.55 µM -0.159785822518235 0.448556903715802 no 1880 0.436524896287169 620 953673
SGTC_709 3807-1509 243 µM -0.15989994928962 0.44850554312138 no 1881 0.436479944233289 630 1886677 YPL242C IQG1
SGTC_1151 3909-8316 15.3 µM -0.160276547236123 0.448336068467475 no 1882 0.436331616312925 661 800431
SGTC_1447 4239-0816 81.9 µM -0.160358245820361 0.448299304137978 no 1883 0.436299439461131 624 1341554
SGTC_2097 5376186 200 µM -0.162467601056602 0.447350249767478 no 1884 0.435468819947082 618 742755
SGTC_1859 st055998 20 µM -0.162586249804898 0.447296875478912 no 1885 0.435422106998456 650 676301
SGTC_3326 9140064 16.379 µM -0.16288207427269 0.447163802628785 no 1886 0.43530564249634 633 1868434
SGTC_64 000l-0018 272.079 µM -0.165509556196556 0.445982126256754 no 1887 0.434271464403361 618 6811119
SGTC_1733 st037357 54.9 µM -0.166288016960874 0.445632115119504 no 1888 0.433965147919189 662 1272339 YGL099W LSG1
SGTC_2895 9054447 58.44 µM -0.167029520398285 0.445298760112066 no 1889 0.43367341063977 608 2697450
SGTC_2369 9071472 200 µM -0.16748858856982 0.445092397869787 no 1890 0.433492812853457 615 17296037
SGTC_2881 9058953 51.95 µM -0.167807199923724 0.444949183106184 no 1891 0.433367479052198 599 17122249
SGTC_2095 5432005 200 µM -0.168031742626682 0.444848256209361 no 1892 0.433279153548761 617 783734
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.1704771949923 0.443749313225378 no 1893 0.432317433798279 626 6708739 YPR165W RHO1
SGTC_1472 k841-0093 193 µM -0.171302753558835 0.443378419036037 no 1894 0.431992857720392 642 X1472
SGTC_583 1488-1091 88.9 µM -0.172075699198837 0.44303120692112 no 1895 0.431689008506898 648 4303273
SGTC_556 4058-0063 51.5 µM -0.174962221512546 0.441734951478625 no 1896 0.430554659253894 641 6615692
SGTC_951 1171-0579 82.7 µM -0.176252834432841 0.441155574720989 no 1897 0.430047657271252 642 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_640 3381-0960 37.1 µM -0.177104767469273 0.440773197282752 no 1898 0.429713048612496 638 1745025
SGTC_20 0481-0013 4.944 µM -0.17727343987332 0.440697497726511 no 1899 0.429646806137561 622 182045
SGTC_1893 st059353 36.1 µM -0.180239588044328 0.439366657893615 no 1900 0.428482240277495 693 3112488
SGTC_514 4466-0038 2.65 nM -0.18068821823052 0.439165427514767 no 1901 0.428306153529823 649 5722064
SGTC_3346 9158254 43.5805 µM -0.181355958040776 0.438865945955995 no 1902 0.428044092990632 617 17639500
SGTC_565 1418-0001 44.5 µM -0.181864560047494 0.438637861232081 no 1903 0.427844508808714 668 2862145
SGTC_2360 9040895 200 µM -0.183734773384366 0.437799331939381 no 1904 0.427110764030839 640 4914414
SGTC_590 k048-0076 22.4 µM -0.184189032686111 0.437595702138634 no 1905 0.42693258146921 643 6832814
SGTC_2138 5575593 77.673 µM -0.184214815760799 0.437584144912567 no 1906 0.426922468541779 642 762213
SGTC_1162 k048-0130 20.1 µM -0.184572460797747 0.437423836536884 no 1907 0.426782193941463 650 6797406
SGTC_2960 9079389 5.97 µM -0.186714507123455 0.436463916177986 no 1908 0.425942240545986 654 16457355
SGTC_1231 0242-0792 125 µM -0.187482750589398 0.436119732229446 no 1909 0.425641073466993 657 3707635
SGTC_1611 st001856 99.4 µM -0.188725449081172 0.435563088221546 no 1910 0.425154002261122 663 647478
SGTC_3103 9120822 49.47 µM -0.189062877502863 0.43541196533476 no 1911 0.425021768091431 624 17141819
SGTC_792 4534-1957 155 µM -0.190373974058425 0.434824858832075 no 1912 0.42450804520502 623 1717904
SGTC_2645 abamectin 100 µM -0.190841508897782 0.434615532321339 no 1913 0.424324883449732 617 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_976 1348-1067 47.6 µM -0.191379363087672 0.434374744831861 no 1914 0.424114193555521 621 5310671 YGL099W LSG1
SGTC_3028 9087778 49.47 µM -0.19196409192542 0.43411300004017 no 1915 0.423885166385691 596 17217395
SGTC_230 MPP+ 141.667 µM -0.192471131737538 0.433886054913683 no 1916 0.423686589337537 651 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_3352 9151559 45.5865 µM -0.192736186879295 0.43376742798173 no 1917 0.423582790863915 611 17159339
SGTC_735 3076-0345 636 µM -0.193672013992598 0.433348641033781 no 1918 0.4232163532554 620 2888990
SGTC_1176 0848-0131 83.3 µM -0.194094577266247 0.433159566514381 no 1919 0.423050913801706 650 6769040
SGTC_3219 9131112 49.47 µM -0.194764589473499 0.432859803176285 no 1920 0.422788622441076 616 17612988 YMR079W SEC14
SGTC_1983 st071813 46.9 µM -0.195134590792122 0.432694281200814 no 1921 0.422643791757675 645 11838595
SGTC_3294 9122953 26.2835 µM -0.195673346826478 0.432453287067981 no 1922 0.422432923631919 613 16459826
SGTC_1970 st070122 35.8 µM -0.196487602824065 0.43208910513785 no 1923 0.422114267529051 673 102928
SGTC_3198 9112019 49.47 µM -0.197040394489937 0.431841897898674 no 1924 0.421897963574588 662 45595555
SGTC_65 0798-0905 34.986 µM -0.198545821975411 0.431168809555615 no 1925 0.42130901875192 742 3602145
SGTC_507 nimesulide 162 µM -0.199357573942661 0.430805951743105 no 1926 0.42099152269922 648 4495 A COX2 inhibitor.
SGTC_564 3555-0129 330 µM -0.199833574773166 0.430593203771457 no 1927 0.42080537101274 630 563260
SGTC_1491 4138-0063 26.5 µM -0.201163814649734 0.429998761728115 no 1928 0.420285242408932 653 23883227
SGTC_2835 9006588 71.43 µM -0.201222841305731 0.429972388252126 no 1929 0.420262165990997 631 2345538
SGTC_1909 st060837 51.5 µM -0.20146830166715 0.429862718392862 no 1930 0.420166206424695 662 678937
SGTC_1013 4112-3890 241 µM -0.201965807105331 0.429640453280756 no 1931 0.419971727644191 632 705171
SGTC_2906 7926292 26.41 µM -0.202300293906384 0.429491030770274 no 1932 0.419840985110538 678 2966319
SGTC_36 0335-0881 14.2 µM -0.202668596905626 0.429326513515604 no 1933 0.41969703490384 638 23828853
SGTC_2892 9047358 58.44 µM -0.202842404689653 0.4292488795836 no 1934 0.419629106343606 654 6466771
SGTC_1818 st052136 56.3 µM -0.202850991593664 0.429245044181172 no 1935 0.419625750422337 631 674169
SGTC_2651 TUB2.036 5 µM -0.204179868183086 0.428651572619568 no 1936 0.419106471414623 633 15992207 YFL037W TUB2
SGTC_143 4032-1194 15.74 µM -0.204958991127921 0.428303694000592 no 1937 0.418802082571245 629 1806963
SGTC_823 0417-1665 178 µM -0.205130285027145 0.428227218686173 no 1938 0.418735167742099 671 3429856
SGTC_113 0099-0221 2.5 µM -0.205491869377345 0.428065795772664 no 1939 0.418593924928631 621 89219
SGTC_2681 menadione 3.18 µM -0.206767314629985 0.427496492177382 no 1940 0.418095791827864 638 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3154 9100113 49.47 µM -0.207211705669102 0.427298170633991 no 1941 0.417922262950821 652 25237525
SGTC_1649 st011737 51.3 µM -0.207305970693994 0.427256104672376 no 1942 0.417885455746988 627 1761035
SGTC_1628 st004252 77.7 µM -0.208303028596428 0.426811216260949 no 1943 0.417496183517706 625 692968
SGTC_216 k038-0035 28.382 µM -0.210476498251588 0.425841734918373 no 1944 0.416647896255413 630 4444231 YPR107C YTH1
SGTC_1409 3909-8004 61.9 µM -0.210894506805119 0.425655332398234 no 1945 0.416484795333074 629 2119279
SGTC_1545 lovastatin 49.4 µM -0.211020836133572 0.425599001638397 no 1946 0.416435506274954 622 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2517 totarol 10 µM -0.213281748925217 0.424591109305729 no 1947 0.41555360415145 640 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1348 1493-0373 93.8 µM -0.213881615015499 0.424323777454565 no 1948 0.415319688793329 673 3010129
SGTC_3250 9135583 49.47 µM -0.214614790300374 0.423997083308776 no 1949 0.41503383081561 627 7699353
SGTC_1470 k295-0292 231 µM -0.214922343163123 0.423860056963348 no 1950 0.414913932300415 631 5045612
SGTC_2999 9069765 71.4286 µM -0.215900037242844 0.423424518772619 no 1951 0.414532834034537 648 2097066
SGTC_656 4090-1979 187 µM -0.215992946372883 0.42338313494446 no 1952 0.414496622889626 654 22330961
SGTC_2109 5483026 200 µM -0.216050678943137 0.423357419977485 no 1953 0.414474122103558 649 759335
SGTC_1430 4049-0248 69.1 µM -0.216349015037285 0.423224541737436 no 1954 0.414357852581735 648 22774488
SGTC_748 act1.228 77.9 µM -0.217550190430397 0.422689629368233 no 1955 0.413889798571806 639 4421505 YNR035C ARC35
SGTC_429 1112-0049 25.5 µM -0.217585847250028 0.422673752699951 no 1956 0.413875906282391 626 2836170
SGTC_1449 4112-4002 201 µM -0.218390004034184 0.422315724715884 no 1957 0.4135626266053 634 2059539
SGTC_210 3551-0445 56.827 µM -0.218421996846821 0.422301482149604 no 1958 0.413550164130058 670 2865180 YOR207C RET1
SGTC_232 clozapine 119 µM -0.218434074495064 0.422296105446329 no 1959 0.413545459427488 642 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_196 k015-0023 18.111 µM -0.218495916098937 0.422268575151784 no 1960 0.413521369969201 640 5211998
SGTC_2728 chlorpromazine 9.18 µM -0.219038673157037 0.422026969949818 no 1961 0.413309961168419 633 2726 A thorazine and dopamine antagonist.
SGTC_874 0599-0792 117 µM -0.22123179826394 0.421051012571479 no 1962 0.4124559755869 683 765305
SGTC_2428 5615643 7.78 µM -0.221629821242123 0.420873941131109 no 1963 0.41230103288297 659 2253075
SGTC_463 ikarugamyin 104 µM -0.221768430292151 0.42081228084874 no 1964 0.412247078248262 651 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_3025 9087895 49.47 µM -0.222485122857095 0.420493490943943 no 1965 0.411968126655828 642 17173641
SGTC_1502 4534-4282 27.7 µM -0.222649594510916 0.42042034014123 no 1966 0.411904117150742 680 3278949
SGTC_1529 apigenin 74 µM -0.223308542554628 0.420127292435024 no 1967 0.411647689565145 690 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1298 1079-1278 263 µM -0.223513260921983 0.420036258986051 no 1968 0.411568031724804 684 2840950
SGTC_363 0455-0021 3.06 µM -0.225601450319815 0.419107935414536 no 1969 0.410755706369363 654 4597466
SGTC_2902 5787006 60.46 µM -0.225993605222419 0.418933649441341 no 1970 0.410603196986614 670 591003
SGTC_1738 st035555 74 µM -0.226256117178885 0.418816989757853 no 1971 0.410501113408904 686 5331140
SGTC_1659 st012954 42.1 µM -0.226343040411458 0.418778362854604 no 1972 0.410467312724135 677 24207262
SGTC_1642 st009582 77.7 µM -0.22709948509249 0.418442247437262 no 1973 0.410173192213237 677 6739311
SGTC_3298 9116858 71.43 µM -0.227154634745631 0.418417744800357 no 1974 0.410151750921736 680 2506942
SGTC_2976 9009005 19.48 µM -0.229054247120229 0.417573953089199 no 1975 0.409413376799205 629 2993148
SGTC_1295 1013-0063 9.78 µM -0.229832500684643 0.417228368786835 no 1976 0.409110964383308 649 6826038
SGTC_1827 berberine 7.24 µM -0.229972390590364 0.417166257300378 no 1977 0.409056611936919 668 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3093 9117344 49.47 µM -0.230099319382573 0.41710990237114 no 1978 0.409007296879595 640 24824913
SGTC_128 0906-2981 13.371 µM -0.230286304227959 0.417026886345029 no 1979 0.408934651145264 672 6740226
SGTC_183 3914-0051 30.55 µM -0.230515134185626 0.416925297296995 no 1980 0.408845752366626 633 1596232
SGTC_2012 4023501 200 µM -0.231135074680526 0.416650102634529 no 1981 0.408604933554295 682 3477460
SGTC_3203 9113543 49.47 µM -0.231464969897478 0.416503677152013 no 1982 0.408476798260049 640 17018012
SGTC_2153 5569715 200 µM -0.232364930143077 0.416104284700618 no 1983 0.408127292600913 650 2054701
SGTC_981 1488-1094 54.9 µM -0.232824558829348 0.415900339939176 no 1984 0.407948820862467 626 3449522
SGTC_1279 0874-0590 65.2 µM -0.233920994153225 0.415413925209045 no 1985 0.407523157172209 644 3523074
SGTC_646 4092-0839 27.3 µM -0.234061030273216 0.415351809903328 no 1986 0.407468799489574 664 877796
SGTC_464 bw-b 70c 158 µM -0.234202472226071 0.415289073164934 no 1987 0.407413897914759 684 5353454
SGTC_1936 st074407 74.3 µM -0.234232560967013 0.415275727548338 no 1988 0.407402219017141 636 809813
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.238730435895912 0.413281839431847 no 1989 0.405657307289235 689 689007
SGTC_2992 9074591 71.4286 µM -0.239291189172143 0.413033415584734 no 1990 0.405439898503604 653 17741321
SGTC_1527 coumarin 137 µM -0.239626358074836 0.412884946316474 no 1991 0.405309964611068 712 323 A hepatotoxic, DNA x-linker.
SGTC_623 k072-0108 16.9 µM -0.239918544475597 0.412755527108051 no 1992 0.405196702125444 671 5382803
SGTC_984 1492-0255 2.91 µM -0.239944666234014 0.412743957362101 no 1993 0.405186576731685 676 1585198
SGTC_184 1494-0393 24.714 µM -0.240103505304608 0.412673606621248 no 1994 0.405125008424773 658 3090647
SGTC_811 0416-0114 265 µM -0.240258269228485 0.412605063484348 no 1995 0.405065021961739 660 6612453
SGTC_2443 5493264 126.67 µM -0.240918936672533 0.41231249157349 no 1996 0.404808972505409 669 5340055
SGTC_35 0133-0054 64.071 µM -0.241854552903282 0.411898243926325 no 1997 0.404446433150132 672 99677
SGTC_701 4424-0219 185 µM -0.242779809034522 0.411488679784435 no 1998 0.40408798887 671 2911779
SGTC_2772 vinpocetine 57.06 µM -0.243550211375619 0.411147735143361 no 1999 0.40378959637067 645 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2105 5350118 200 µM -0.244308648664165 0.410812151227918 no 2000 0.403495892863944 657 2133313
SGTC_453 enantio-paf c16 10 µM -0.24437389089319 0.410783286701804 no 2001 0.403470630465005 684 13871343 A lipid and platelet activating factor
SGTC_2952 9073731 13.78 µM -0.246411964002808 0.409881844590007 no 2002 0.402681672892154 675 16457353
SGTC_103 0844-0104 51.839 µM -0.246620293378833 0.409789727004687 no 2003 0.402601048863282 655 5375804
SGTC_2872 9044037 25.97 µM -0.248949420883003 0.408760190293179 no 2004 0.401699953042224 644 6465195
SGTC_1597 7-benzyloxygramine 47.5 µM -0.249972875329006 0.408307994606693 no 2005 0.401304162598089 669 260807
SGTC_2923 7992654 58.14 µM -0.250863870361317 0.407914423198993 no 2006 0.400959679300196 631 2985126
SGTC_1370 2001-0092 44.6 µM -0.251641513122843 0.407570997803183 no 2007 0.40065908403412 653 790957
SGTC_1695 st026914 34.495 µM -0.251706241920192 0.407542415236916 no 2008 0.400634065978495 658 3289191
SGTC_1124 fisetin 1.16336 µM -0.253114126410017 0.40692085181241 no 2009 0.400090011474062 685 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_3247 9135149 49.47 µM -0.254018778543618 0.406521582771313 no 2010 0.39974052531841 656 8934436 YOR116C RPO31
SGTC_1188 1403-0014 4.57 µM -0.254421063226068 0.406344065247281 no 2011 0.399585140058682 661 9614867
SGTC_2880 9042983 58.44 µM -0.254999156026336 0.406089001993108 no 2012 0.399361875541618 682 6464714
SGTC_2383 9036125 200 µM -0.255074567580962 0.406055732215127 no 2013 0.399332753361892 665 79580
SGTC_1699 st031318 29.054 µM -0.255192430315866 0.406003735348439 no 2014 0.399287238650593 677 5340658
SGTC_1368 1852-0141 284 µM -0.258963960467171 0.40434074995846 no 2015 0.397831523767132 680 2838987
SGTC_2006 4011487 200 µM -0.25909923660775 0.404281134387984 no 2016 0.397779336895779 656 45595294
SGTC_714 4296-0578 26.1 µM -0.25911309913091 0.40427502536357 no 2017 0.397773989110616 643 1589775
SGTC_876 0720-0963 56.8 µM -0.259468485686649 0.404118419341228 no 2018 0.397636897184982 715 765861
SGTC_1866 st057638 64 µM -0.260329678744886 0.403738986433818 no 2019 0.397304740640802 657 688802
SGTC_1153 4055-0057 267 µM -0.260725458140084 0.403564640409968 no 2020 0.397152116068989 644 882706
SGTC_1117 retinoic acid 1.10837 µM -0.260762242213976 0.403548437514797 no 2021 0.397137931810879 684 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1330 1469-0054 61.8 µM -0.26195831017441 0.403021675848748 no 2022 0.396676791863566 679 7102664
SGTC_2714 st079313 56.9 µM -0.262259017034265 0.402889268836702 no 2023 0.396560878054433 649 2939799
SGTC_1694 st024011 44.9 µM -0.263031472179203 0.402549193062857 no 2024 0.396263160830308 695 2787533
SGTC_1302 1159-0335 255 µM -0.266672658236166 0.400947146593033 no 2025 0.394860603670421 675 649284
SGTC_1697 st025554 27.742 µM -0.266779254587147 0.400900271350295 no 2026 0.394819563991444 644 1269519
SGTC_644 1498-1197 63.3 µM -0.266855898063189 0.400866568624765 no 2027 0.394790056914082 667 6741615
SGTC_2325 6158266 200 µM -0.267053911830148 0.400779498698434 no 2028 0.394713826115415 650 3623240
SGTC_2402 5553605 200 µM -0.267754173817781 0.400471621493548 no 2029 0.394444273522888 678 6758546
SGTC_1278 0874-0585 172 µM -0.267828633452639 0.400438888201818 no 2030 0.394415614666662 659 766306
SGTC_2690 usnic acid 100 µM -0.267967319586853 0.400377922083946 no 2031 0.394362237121452 704 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2436 5633522 8.09 µM -0.26935292119712 0.399768948182042 no 2032 0.393829055583675 691 5724242
SGTC_2034 5197015 53.07 µM -0.269846160236641 0.399552227657273 no 2033 0.393639304443529 712 780676
SGTC_579 4491-1009 110 µM -0.270468782152418 0.39927870277485 no 2034 0.393399815229612 665 1271041
SGTC_776 4476-4378 112 µM -0.270626759603302 0.399209309343703 no 2035 0.393339056198917 696 2892008
SGTC_319 1348-1596 45.5 µM -0.270650632913645 0.399198822991659 no 2036 0.393329874613182 701 5380505
SGTC_642 0335-0876 158 µM -0.271391181157117 0.398873573320448 no 2037 0.393045092019197 641 6812350
SGTC_2855 9016525 58.44 µM -0.271729178171203 0.398725147950163 no 2038 0.392915132104012 665 43811474
SGTC_961 1252-1571 372 µM -0.272316857150625 0.398467114072414 no 2039 0.392689197851728 695 6813498
SGTC_2458 5808907 16.39 µM -0.273607248133841 0.39790069430836 no 2040 0.392193231641089 692 2731747
SGTC_1011 4112-3381 17.4 µM -0.27419733349506 0.397641746741411 no 2041 0.391966488593503 701 2877139
SGTC_1406 3909-7906 11.9 µM -0.274866793061298 0.397348021943747 no 2042 0.391709290059636 660 X1406
SGTC_2279 7948423 32.93 µM -0.275157629743785 0.397220435729309 no 2043 0.391597568747443 650 1247112
SGTC_2704 st078022 71.1 µM -0.275314438103852 0.397151650533459 no 2044 0.391537336465595 708 54697681
SGTC_1931 st074438 57.1 µM -0.276973184450094 0.396424224958232 no 2045 0.390900348322606 700 2787313
SGTC_2116 5511452 16.8835 µM -0.277258614071686 0.396299089105522 no 2046 0.390790767723624 689 870744
SGTC_2355 9061122 103.12 µM -0.277894873246187 0.396020183732809 no 2047 0.390546529759137 693 5302957
SGTC_1646 st011709 75.6 µM -0.27937547377365 0.395371366030179 no 2048 0.389978345566567 649 5757843
SGTC_165 k038-0023 64.381 µM -0.280212698455306 0.395004611884779 no 2049 0.389657162408626 670 46368543
SGTC_2172 5754775 163.918 µM -0.280230860733257 0.394996656757664 no 2050 0.389650195677331 662 2263357
SGTC_804 1595-0054 20.9 µM -0.281551524436262 0.394418319976718 no 2051 0.38914370740791 698 761523 Stimulates phospholipase C.
SGTC_1590 st077108 57.8 µM -0.28168233903354 0.39436104711083 no 2052 0.389093548884876 673 5489485
SGTC_2312 7706453 155.7 µM -0.285069145028006 0.392879043937065 no 2053 0.387795584195051 682 976098
SGTC_3238 9133470 49.47 µM -0.2857139302622 0.392597073085077 no 2054 0.387548617231442 675 3534688
SGTC_456 gingerol 170 µM -0.286234243084162 0.392369576315428 no 2055 0.38734935910964 707 442793 A herb.
SGTC_1418 3966-3099 2.4 µM -0.287768268258947 0.391699067653942 no 2056 0.386762064309037 672 740335
SGTC_136 0097-0015 404.482 µM -0.28937821382078 0.390995720731607 no 2057 0.386145982504093 670 4861337
SGTC_861 0443-0273 110 µM -0.292277627724821 0.389729936016939 no 2058 0.385037181426943 677 6149169
SGTC_903 1134-0042 114 µM -0.293465175615971 0.389211829909435 no 2059 0.384583307053804 661 701009
SGTC_2832 7992762 51.95 µM -0.294330410839283 0.388834467048495 no 2060 0.38425271839289 650 2985177
SGTC_331 k048-0133 24.5 µM -0.294427394647982 0.388792175152368 no 2061 0.384215668107995 653 6813582
SGTC_532 1548-0774 215 µM -0.29470117647745 0.388672793752563 no 2062 0.384111082186255 720 5932993
SGTC_1904 st060225 78 µM -0.295770960328404 0.388206419961343 no 2063 0.383702500788803 648 66595
SGTC_358 0075-0058 9.45 µM -0.296088232401525 0.38806813570536 no 2064 0.383581350239592 761 1069125
SGTC_888 0916-0002 6.97 µM -0.296656670416237 0.387820415305669 no 2065 0.383364320278461 669 2802138 YIL048W NEO1
SGTC_676 falcarinol 140 µM -0.298042177215118 0.387216814771915 no 2066 0.382835486414674 713 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_3140 9094243 49.47 µM -0.299326358671198 0.386657600318505 no 2067 0.382345522348805 699 19291112
SGTC_3099 9120367 49.47 µM -0.299421410830554 0.386616217887608 no 2068 0.382309263810545 687 24824940
SGTC_3110 9122132 49.47 µM -0.300046241685466 0.38634422020464 no 2069 0.382070941917978 656 918317
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.300784397557004 0.386022962502146 no 2070 0.381789453367258 701 364106
SGTC_2515 chrysin 20.77 µM -0.301423399926154 0.38574492114342 no 2071 0.381545826497054 678 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_3214 9129694 49.47 µM -0.302005667423572 0.385491617244188 no 2072 0.381323871291721 700 17158655
SGTC_921 1561-0023 372 µM -0.302122245340961 0.385440908202838 no 2073 0.381279437510536 684 24050882
SGTC_379 3970-0972 5.9 µM -0.302248078988136 0.385386175303565 no 2074 0.38123147765566 670 2898042 YBL034C STU1
SGTC_3065 9113888 49.47 µM -0.302512507907623 0.385271166118199 no 2075 0.381130699963521 714 16648368
SGTC_2586 curcumin 80 µM -0.302528569476159 0.385264180717385 no 2076 0.381124578926686 693 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2313 7726885 200 µM -0.303970536472699 0.384637201054176 no 2077 0.380575169092846 668 726423
SGTC_574 1315-0397 40 µM -0.304695786315826 0.384321970073003 no 2078 0.380298929572408 674 6794277
SGTC_1744 st037937 38.9 µM -0.305051010939675 0.384167599028097 no 2079 0.380163650763481 703 1016152
SGTC_2158 5657123 3.6195 µM -0.305446885317957 0.383995584343565 no 2080 0.380012908738026 738 2858827
SGTC_1317 1273-0028 910 nM -0.305608262722282 0.383925469453115 no 2081 0.379951464278808 692 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2585 alliin 100 µM -0.30694498464295 0.383344839804477 no 2082 0.379442623944567 717 87310 A garlic compound which reacts with lipids.
SGTC_2894 9048625 32.47 µM -0.308011031260098 0.382881970593685 no 2083 0.379036969207736 682 4092861
SGTC_688 0527-0193 473 µM -0.308155570456798 0.382819225647917 no 2084 0.378981979032671 678 4007154
SGTC_1498 4478-3555 97.6 µM -0.308829979153976 0.382526503263498 no 2085 0.378725431526587 681 3437919
SGTC_1873 rapamycin 2 nM -0.308886779815151 0.382501852394944 no 2086 0.378703826787701 672 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1920 st075728 45.7 µM -0.310239155463489 0.381915076910008 no 2087 0.378189548339475 703 3400306
SGTC_2322 7413319 38.22 µM -0.310240465069003 0.381914508823054 no 2088 0.378189050429975 690 1840400
SGTC_2558 carylophyllene oxide 100 µM -0.310420083828226 0.38183659534677 no 2089 0.37812076163983 703 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2927 9011802 47.9 µM -0.311108028252182 0.381538229044044 no 2090 0.377859249068765 686 43912568
SGTC_2552 juarezic acid 87.02 µM -0.311210580595655 0.38149375739965 no 2091 0.377820270002239 678 1549512
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.31321817870563 0.380623481763321 no 2092 0.377057454098899 711 688751
SGTC_1675 st018485 24.5 µM -0.314703016513518 0.379980206113925 no 2093 0.376493576851951 675 3323024
SGTC_2184 6075246 200 µM -0.316052032700219 0.379396060100241 no 2094 0.375981507144995 664 2267320
SGTC_2947 9072639 7.68 µM -0.317467463101571 0.378783451518577 no 2095 0.375444462108873 697 16488146
SGTC_1342 1486-1464 234 µM -0.31797144457993 0.378565398078565 no 2096 0.375253298787247 690 3253938
SGTC_883 0850-0245 24.6 µM -0.318921659346718 0.378154381823954 no 2097 0.374892959749742 673 6823229 YPR165W RHO1
SGTC_2146 5545642 200 µM -0.31917264650984 0.378045840096497 no 2098 0.37479779898551 685 825326
SGTC_964 1287-0107 19.4 µM -0.320078252182819 0.377654282600121 no 2099 0.374454505682034 691 51516812 YPR165W RHO1
SGTC_2227 7312221 64.1025 µM -0.32164881756467 0.376975514130549 no 2100 0.373859378210818 678 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1367 1812-0510 76.9 µM -0.323100938834202 0.37634827299124 no 2101 0.373309399638593 676 1142582 YDR527W RBA50
SGTC_1897 st060201 15 µM -0.324325345955777 0.375819646120175 no 2102 0.372845866288557 686 611878
SGTC_2 0422-0095 29 µM -0.324355050621421 0.375806824286058 no 2103 0.372834623045731 669 6790840
SGTC_1084 voriconazole 435 nM -0.324929500942101 0.375558893363099 no 2104 0.372617214393967 700 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3275 9138069 49.47 µM -0.324973151020723 0.375540056227827 no 2105 0.372600696077269 685 17617007
SGTC_3181 9108277 49.47 µM -0.325372293228008 0.375367820687904 no 2106 0.372449661231952 713 17097298
SGTC_3317 9138495 8.753 µM -0.325617646696672 0.375261959502065 no 2107 0.372356829559748 679 17020139
SGTC_1887 st057648 70.8 µM -0.325724136821374 0.375216015771171 no 2108 0.372316540379345 695 688672
SGTC_1193 1488-0126 41.5 µM -0.325752989563505 0.375203567948707 no 2109 0.372305624552969 662 1384710
SGTC_2079 5212404 121 µM -0.32617881886094 0.375019869247477 no 2110 0.37214453295569 702 758462
SGTC_2564 betulinic acid 100 µM -0.326263212486185 0.374983466006166 no 2111 0.372112609428754 728 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1440 4100-1550 40 µM -0.326438656646539 0.374907791625982 no 2112 0.372046247082771 702 742806
SGTC_2437 5741531 144.16 µM -0.326576755283022 0.374848228888495 no 2113 0.371994013480366 687 2262990
SGTC_1475 4092-1048 11.7 µM -0.326769834102603 0.374764957885989 no 2114 0.371920988451627 702 2881759
SGTC_2149 5554786 194.827 µM -0.326847456212579 0.374731482680086 no 2115 0.371891632014936 691 745063 YPR165W RHO1
SGTC_2026 5148700 152 µM -0.328132023242706 0.374177639285649 no 2116 0.371405921091291 671 79838
SGTC_3126 9127922 49.47 µM -0.328763022698249 0.373905677733947 no 2117 0.371167407197382 743 45595682
SGTC_2782 7736369 71.43 µM -0.329839626812568 0.373441804972869 no 2118 0.370760571761107 692 2950836 YOL077C BRX1
SGTC_203 k066-0004 30.888 µM -0.331448840288122 0.372748790599564 no 2119 0.370152739243101 700 6795412
SGTC_447 ml7 120 µM -0.331687596313798 0.372646004357023 no 2120 0.370062583834767 694 4216 Selective myosin light chain kinase inhibitor.
SGTC_1802 st050112 57.9 µM -0.33227400058632 0.372393591463485 no 2121 0.369841185108905 679 4662563
SGTC_2253 7938677 135.83 µM -0.33319334440371 0.371997977830345 no 2122 0.369494170888303 689 2301972
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.334423370792836 0.371468882077121 no 2123 0.369030053132685 698 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_152 4469-0003 551.229 µM -0.338966341978408 0.36951683447276 no 2124 0.367317542953236 708 697280
SGTC_1795 st049545 62.3 µM -0.339279752906697 0.36938228970764 no 2125 0.367199496945809 663 5291882
SGTC_598 3937-0236 20.2 µM -0.339736731201516 0.369186141307692 no 2126 0.367027398885793 703 1379313
SGTC_3081 9117243 49.47 µM -0.340510778038594 0.368853975568184 no 2127 0.36673595375857 710 45595589
SGTC_2607 solasodine 47.35 µM -0.340572291198366 0.36882758270135 no 2128 0.366712796035607 677 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_3235 9132602 49.47 µM -0.340665215354906 0.368787713789776 no 2129 0.366677814004305 702 4912240
SGTC_2735 sertaconazole 140 nM -0.340755528309298 0.368748966562018 no 2130 0.36664381604177 683 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2620 irigenin 100 µM -0.341109009184487 0.368597324474351 no 2131 0.366510759596485 674 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2391 6285546 200 µM -0.342173227617001 0.368140902017634 no 2132 0.366110265894593 677 846083
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.34302432303342 0.367776017713564 no 2133 0.365790080967924 724 229346 A bile salt which induces apoptosis.
SGTC_3156 9099931 49.47 µM -0.345063932319128 0.366902076077257 no 2134 0.365023153926404 674 18111053
SGTC_3258 9138477 49.47 µM -0.34578464213193 0.366593427453777 no 2135 0.364752283911469 682 4970355
SGTC_2111 5486399 200 µM -0.3460650957384 0.366473344689669 no 2136 0.364646897071336 685 689674
SGTC_892 0929-0076 29 µM -0.347605118495289 0.365814181204439 no 2137 0.364068380867345 672 5751038
SGTC_1355 1499-0035 1.68 µM -0.348306211130416 0.365514229233034 no 2138 0.363805114874195 704 1548538
SGTC_2553 4-methylesculetin 85.09 µM -0.348789500249038 0.365307509094746 no 2139 0.363623673296077 702 5319502
SGTC_772 k072-0172 35.3 µM -0.349536582758152 0.364988032043301 no 2140 0.363343255767882 684 5861980
SGTC_1514 1189-1591 158 µM -0.350615610427752 0.364526769771591 no 2141 0.36293837185296 743 767698 YMR146C TIF34
SGTC_384 k007-0144 5.16 µM -0.353077814399072 0.363474963053501 no 2142 0.362015052340382 692 6824886
SGTC_2949 9072542 2.23 µM -0.353160751346916 0.363439551825787 no 2143 0.361983965160643 730 16457352
SGTC_711 k292-0785 179 µM -0.353470910063398 0.363307135051915 no 2144 0.361867716725844 704 4146315
SGTC_3012 9080433 71.4286 µM -0.355594352495202 0.36240100835317 no 2145 0.36107218681387 714 17688859
SGTC_1329 1447-1697 50.6 µM -0.357783455686169 0.361467668905689 no 2146 0.360252686285873 699 2840515
SGTC_2191 5911152 200 µM -0.358807850000498 0.361031193817275 no 2147 0.359869419871853 694 2875902
SGTC_1915 st067105 30.6 µM -0.359131361790318 0.360893389105125 no 2148 0.359748410568257 716 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1411 3909-8223 150 µM -0.359861066516258 0.360582626723776 no 2149 0.359475516784011 725 X1411
SGTC_1014 4130-3005 69.3 µM -0.360031721499089 0.360509962452013 no 2150 0.359411705844808 715 743608
SGTC_146 3448-8650 53.125 µM -0.362531489735083 0.359446148745342 no 2151 0.358477448115049 730 2891488 YIL048W NEO1
SGTC_2534 helenine 20.12 µM -0.36320181508806 0.359161066510626 no 2152 0.358227065916962 695 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_789 1309-1135 70.6 µM -0.363726947813014 0.35893778791362 no 2153 0.358030959134646 691 3092424
SGTC_2569 tetrandrine 100 µM -0.363925439547517 0.358853404735352 no 2154 0.357956843672591 687 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1921 5740136 50 µM -0.364465709154394 0.358623759206946 no 2155 0.357755137805042 729 1774243
SGTC_366 0181-0206 4.31 µM -0.365442957334959 0.358208502629939 no 2156 0.357390389973436 731 274874
SGTC_575 k072-0246 11.9 µM -0.365465603601911 0.358198881664835 no 2157 0.357381939030079 713 6796779
SGTC_344 k064-0035 6.43 µM -0.365975174909674 0.357982420893549 no 2158 0.357191799997478 718 5088750
SGTC_288 1315-0019 35.1 µM -0.366146585893026 0.357909617487595 no 2159 0.357127848479417 697 6811474
SGTC_974 1326-0144 138 µM -0.366752176927115 0.357652446137663 no 2160 0.356901941396769 721 5411856
SGTC_3288 9119690 36.221 µM -0.366803429092368 0.357630684267261 no 2161 0.356882824810404 729 17595618 YKL019W RAM2
SGTC_3003 9075612 71.4286 µM -0.366818593151048 0.357624245637189 no 2162 0.356877168824846 742 6501993
SGTC_703 3875-0075 71.8 µM -0.367184798081737 0.357468768038058 no 2163 0.356740588973342 721 2850814
SGTC_2093 5331342 194.4 µM -0.367572779328659 0.357304070794633 no 2164 0.356595907458119 708 33839
SGTC_1239 0337-0584 35.4 µM -0.367594113797285 0.357295015127138 no 2165 0.356587952251127 720 914301 YML130C ERO1
SGTC_994 3910-0338 138 µM -0.369169163088297 0.356626689127095 no 2166 0.356000819639596 703 3479481
SGTC_2803 7707263 71.43 µM -0.369199062835851 0.356614006294389 no 2167 0.355989677179445 698 2199229
SGTC_840 0245-0196 390 µM -0.371532772842544 0.355624586576272 no 2168 0.355120375369435 687 3827528
SGTC_37 0566-0070 1.56 µM -0.372868078796806 0.355058895539494 no 2169 0.354623315466388 721 1626686
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.374605873480635 0.354323171902219 no 2170 0.353976802108316 689 3256 An antibiotic and ribosome inhibitor.
SGTC_1999 st074831 12.5 µM -0.375221213368956 0.354062787868132 no 2171 0.353747977421686 755 17112523
SGTC_1506 4226-2149 212 µM -0.375244324758786 0.354053009501004 no 2172 0.353739384084015 718 991114
SGTC_795 0685-0265 78 µM -0.375251527182821 0.354049962194359 no 2173 0.353736706075024 693 302754
SGTC_2371 9071574 200 µM -0.375349210483688 0.354008633841407 no 2174 0.353700386134909 725 45596039
SGTC_2619 obliquin 87.91 µM -0.375658700258846 0.353877704675683 no 2175 0.353585322547672 701 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1067 clotrimazole 1.36 µM -0.375810283437147 0.353813583951925 no 2176 0.353528971109191 702 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1780 st038448 24.544 µM -0.377127396006871 0.353256611026049 no 2177 0.353039466350449 739 728868 YDL195W SEC31
SGTC_2857 9024691 58.44 µM -0.378146581205338 0.352825839430288 no 2178 0.352660853059333 761 16478292
SGTC_430 0958-0115 16.4 µM -0.37857651796146 0.35264417771776 no 2179 0.352501181197118 708 6833180
SGTC_2024 5144227 134 µM -0.378885663947186 0.352513574642212 no 2180 0.352386385218386 706 3475211
SGTC_1986 st071812 45 µM -0.379044986664187 0.352446273304173 no 2181 0.352327228751254 721 11838594
SGTC_857 0438-0306 1.35 µM -0.380157518015413 0.351976445016669 no 2182 0.351914245903273 690 4686136
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.38069149633451 0.351751023136896 no 2183 0.351716089766202 700 16486 A toxic proline analog.
SGTC_737 1950-0117 57.9 µM -0.381953982839479 0.351218264892859 no 2184 0.35124774890527 721 5393513
SGTC_1751 st044839 27.194 µM -0.382165375900489 0.351129087408876 no 2185 0.351169351101421 706 5291326
SGTC_1632 st005650 90 µM -0.382842115336783 0.350843655795674 no 2186 0.35091841628454 703 2759605
SGTC_2528 xanthyletin 44.79 µM -0.383241229878002 0.350675358797183 no 2187 0.350770455177927 710 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1158 4092-0494 91.8 µM -0.383346611737626 0.350630926690982 no 2188 0.350731391430427 728 1148199
SGTC_651 3253-0966 34.4 µM -0.384710698983605 0.350055971792186 no 2189 0.350225883768073 706 781462
SGTC_4 0960-0234 25.671 µM -0.384827059625829 0.350006942338571 no 2190 0.350182774747296 689 6821112
SGTC_1177 0983-0204 23.6 µM -0.385570456168336 0.3496937655222 no 2191 0.34990740850203 706 766818
SGTC_2216 7189485 200 µM -0.385914994020557 0.349548653872962 no 2192 0.349779812798641 708 731273
SGTC_1183 1254-0324 198 µM -0.386636867691283 0.349244688102897 no 2193 0.349512530057621 701 5799357
SGTC_95 0471-0001 561.058 µM -0.388708068800741 0.348373086224216 no 2194 0.348746056417577 693 4015405
SGTC_1210 3013-0140 750 nM -0.39010674732643 0.347784947228203 no 2195 0.348228806843839 728 905973
SGTC_3276 9139060 49.47 µM -0.390194322590702 0.347748134327281 no 2196 0.348196429745441 741 4870619
SGTC_827 3253-0474 693 µM -0.390380262793359 0.347669977766796 no 2197 0.348127690210144 736 5402065
SGTC_378 3970-0959 8.33 µM -0.390702949030913 0.347534357881206 no 2198 0.348008409390684 746 6615653
SGTC_2271 7849410 118.62 µM -0.391293015448973 0.347286412838863 no 2199 0.347790330507459 751 972430
SGTC_2584 androsterone 48.74 µM -0.392601728624943 0.346736726787733 no 2200 0.347306831307519 720 2754130 A steroid.
SGTC_2774 tamoxifen 10.92 µM -0.393266964630657 0.346457437730133 no 2201 0.347061157511304 712 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2110 5483698 200 µM -0.393593269435201 0.346320474196928 no 2202 0.346940675583812 698 2848765 YHR062C RPP1
SGTC_2352 9027995 87.8 µM -0.394768288181386 0.345827437123537 no 2203 0.346506950209528 710 2997347
SGTC_2912 7964298 10.93 µM -0.395022530127788 0.345720791734599 no 2204 0.346413130342934 718 2975850
SGTC_135 0933-0004 26.348 µM -0.395529662089913 0.34550810461067 no 2205 0.346226017642445 726 21230617 YGL099W LSG1
SGTC_3050 9093513 49.47 µM -0.397472342000742 0.344693811762123 no 2206 0.345509589101999 730 25236664
SGTC_2222 6885208 172.143 µM -0.39837269533548 0.344316663658411 no 2207 0.345177740929234 698 609514
SGTC_1953 st076800 12.1 µM -0.400874389474762 0.343269544912852 no 2208 0.344256303202282 714 297591
SGTC_233 rapamycin 362 pM -0.401530940638562 0.342994935135426 no 2209 0.344014631479602 709 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.402908075716552 0.342419202658477 no 2210 0.34350792508933 714 6857784
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.404302169280096 0.341836753160549 no 2211 0.342995265242121 697 688664
SGTC_1388 3346-4487 254 µM -0.406583210053618 0.340884550879941 no 2212 0.342157065443079 739 3345614
SGTC_913 3487-1245 167 µM -0.407501694454207 0.340501422545839 no 2213 0.3418197749422 703 4016153
SGTC_2174 5790901 200 µM -0.408186486254712 0.340215881684518 no 2214 0.341568384343246 718 786020
SGTC_995 3931-2021 34.6 µM -0.408866508588358 0.339932420213705 no 2215 0.341318814167185 730 730143
SGTC_1051 3253-3903 78 µM -0.409990315380535 0.339464169360763 no 2216 0.340906525920202 715 5509239
SGTC_1358 1509-0022 2.48 µM -0.410004517979836 0.339458253219764 no 2217 0.340901316661702 727 3258434
SGTC_2540 epiandrosterone 100 µM -0.414257787722747 0.337688325053417 no 2218 0.339342662338139 720 441302 A steroid.
SGTC_1054 3429-0080 167 µM -0.414517622427777 0.337580314888195 no 2219 0.339247531940386 763 1162877
SGTC_522 1273-0010 11.6 µM -0.415145646291904 0.337319308172778 no 2220 0.339017642850046 734 5705015
SGTC_980 1473-0395 201 µM -0.417048828310348 0.336528824142292 no 2221 0.338321346473937 728 768876
SGTC_1316 1272-0050 65.9 µM -0.418209761565243 0.336046986348963 no 2222 0.337896879672186 750 7340392
SGTC_667 1498-1044 59 µM -0.419900765809056 0.335345627973606 no 2223 0.337278974149349 747 6739982
SGTC_75 0159-0059 199.013 µM -0.419970000101649 0.335316924667247 no 2224 0.337253684760332 779 5377270
SGTC_2582 agaric acid 100 µM -0.420037263138294 0.335289039529235 no 2225 0.337229116121277 718 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_43 0570-0105 72.5 µM -0.420603708396251 0.335054245168083 no 2226 0.337022242673237 745 1114046 YDL195W SEC31
SGTC_1846 st056244 14.8 µM -0.420853210492742 0.33495084575364 no 2227 0.336931136773407 734 5393182
SGTC_2480 5767542 37.17 µM -0.420867150864004 0.334945068911689 no 2228 0.336926046717273 701 2867358
SGTC_1339 1486-1321 22.7 µM -0.422543569108645 0.334250652021459 no 2229 0.336314153084702 727 3469382
SGTC_825 1988-2224 89.6 µM -0.422926253332751 0.334092213457567 no 2230 0.336174533813289 727 1180859
SGTC_1901 st060216 58.6 µM -0.422953654813378 0.334080869856063 no 2231 0.336164537469413 710 688792
SGTC_3029 9088683 49.47 µM -0.423839669152728 0.33371416142758 no 2232 0.335841372734602 726 25236615
SGTC_2723 salbutamol 83.58 µM -0.426632227518375 0.332559402465639 no 2233 0.334823610278344 751 9884233 β2-adrenoceptor agonist
SGTC_501 nsc-95397 161 µM -0.427799009519537 0.332077392475451 no 2234 0.334398729061478 743 262093
SGTC_92 0063-0024 660.874 µM -0.42783232347338 0.332063634202856 no 2235 0.334386600966162 738 3594437
SGTC_2513 baicalein 25.65 µM -0.431569370459753 0.330521718474649 no 2236 0.33302721200284 749 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2765 myclobutanil 7.74 µM -0.43198783645879 0.330349236622127 no 2237 0.332875126828493 779 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1925 st057770 10.1 µM -0.432046726644925 0.330324966362867 no 2238 0.332853726282004 731 5989122
SGTC_1273 0849-0096 14.1 µM -0.432981948397656 0.329939631586165 no 2239 0.332513942057969 751 5286025
SGTC_3234 9132280 49.47 µM -0.433436690479582 0.32975233161325 no 2240 0.332348775119968 728 17612295
SGTC_1208 2323-2347 50.3 µM -0.433630234489895 0.329672627311009 no 2241 0.332278487845559 739 5412760
SGTC_248 streptozotocin 5.23457 mM -0.433672482954005 0.329655229793503 no 2242 0.332263145714362 768 5300 DNA alkylating agent.
SGTC_958 1222-0007 33 µM -0.433799842567472 0.329602786541122 no 2243 0.332216897973158 752 7312461
SGTC_2977 9011197 71.43 µM -0.43385501235554 0.329580070151019 no 2244 0.332196865114985 767 2704722
SGTC_1555 citronellol 128 µM -0.434047762827631 0.329500709277642 no 2245 0.33212687870894 744 8842 A terpine precursor.
SGTC_3227 9130768 49.47 µM -0.434543292658441 0.329296720748013 no 2246 0.331946982024424 742 17720899
SGTC_341 1486-1430 230 µM -0.434950757482009 0.329129022889905 no 2247 0.331799085395029 747 2054753 YPL210C SRP72
SGTC_3260 9137109 49.47 µM -0.435181264060909 0.329034169900077 no 2248 0.331715430524399 751 17478346
SGTC_2442 5158906 48.48 µM -0.43565486253556 0.328839319633702 no 2249 0.331543579686832 719 1893835
SGTC_2468 5987765 72.9 µM -0.435706753448701 0.328817973239592 no 2250 0.331524752606542 702 26772094
SGTC_906 1165-0455 526 µM -0.436235637820407 0.328600437638976 no 2251 0.331332886868842 763 3252859
SGTC_3232 9132874 49.47 µM -0.436280434465562 0.328582014983276 no 2252 0.331316637823134 739 3784940
SGTC_865 0488-0499 301 µM -0.43641458908966 0.328526846280599 no 2253 0.331267977939958 749 9634651
SGTC_807 1315-0151 48 µM -0.436816787630613 0.328361471690542 no 2254 0.331122111606026 765 4011080
SGTC_3223 9129970 49.47 µM -0.43708435106525 0.328251474515578 no 2255 0.33102508790963 715 17248386
SGTC_1941 st076221 61.8 µM -0.438459663209475 0.327686309330132 no 2256 0.330526552192377 696 2828568
SGTC_1286 0929-0070 131 µM -0.438917270944304 0.327498349276873 no 2257 0.330360740954995 736 1420408
SGTC_1707 st032323 6.317 µM -0.439307772183847 0.327337987442377 no 2258 0.330219271659314 739 3132057 YMR211W DML1
SGTC_2560 caryophyllene 100 µM -0.440104541054802 0.327010888047357 no 2259 0.329930696568758 727 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.440256460736881 0.326948535176613 no 2260 0.329875685522663 721 676296 Flavone; oxidizing agent.
SGTC_979 1426-2828 121 µM -0.440826725040957 0.326714522928192 no 2261 0.329669222164766 743 747872
SGTC_935 2996-0153 430 µM -0.441476488882595 0.326447970514455 no 2262 0.32943403937072 754 23738523
SGTC_2683 piperine 63.03 µM -0.441679375411509 0.326364758583032 no 2263 0.329360618166317 750 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_600 1495-0418 41.6 µM -0.442163719853071 0.326166144377348 no 2264 0.329185368706855 736 5377768
SGTC_719 2810-4230 27.3 µM -0.442190513119718 0.326155158751784 no 2265 0.329175675243503 730 721079
SGTC_3256 9138902 49.47 µM -0.44309431843663 0.325784673967709 no 2266 0.328848757279405 757 17228773
SGTC_765 1319-0117 244 µM -0.444582524408947 0.325175008522362 no 2267 0.328310739423731 708 3487746 YGL099W LSG1
SGTC_593 1203-0218 61.7 µM -0.446287037837842 0.324477304174525 no 2268 0.327694959109192 753 3666956
SGTC_3052 9092717 49.47 µM -0.446414996062055 0.324424952158321 no 2269 0.327648751213385 760 25237534
SGTC_2275 7947463 200 µM -0.447377648705431 0.324031209868781 no 2270 0.327301205599794 753 1225414
SGTC_1118 chelidonine 707.474 nM -0.451155555435669 0.322487882705168 no 2271 0.325938719788951 754 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1021 4476-0760 85.3 µM -0.451611189052852 0.32230195592578 no 2272 0.325774553971177 725 746768
SGTC_1206 3978-0017 132 µM -0.451674529773348 0.322276112500628 no 2273 0.325751734840555 766 3873677
SGTC_2202 7226349 200 µM -0.452472225888891 0.321950720874679 no 2274 0.325464412709679 705 844334
SGTC_2549 cedrol 20.94 µM -0.452580479028631 0.321906573385564 no 2275 0.325425429002759 741 6708665 A sedative which affects the nervous system.
SGTC_625 k213-0058 121 µM -0.452682251387145 0.321865071162674 no 2276 0.325388780871803 729 3655420
SGTC_1335 1486-0900 202 µM -0.453881705408169 0.321376107772668 no 2277 0.324956985891502 710 X1335
SGTC_2067 5224629 34.075 µM -0.454045142099597 0.321309505926439 no 2278 0.324898168018118 746 2835000
SGTC_2134 5324836 1.464 µM -0.454258854823212 0.321222424837115 no 2279 0.324821263306305 757 699272
SGTC_3123 9126162 49.47 µM -0.454391579527076 0.321168348718679 no 2280 0.324773505962503 705 25239884
SGTC_293 4049-0273 38.5 µM -0.454764790281994 0.321016311525456 no 2281 0.324639231748013 732 1380311
SGTC_2786 7743617 45.45 µM -0.455308139964713 0.320795017417136 no 2282 0.324443785487311 747 583674
SGTC_315 k915-0449 187 µM -0.456451335747633 0.320329627424633 no 2283 0.324032728773932 738 20970215 YNL149C PGA2
SGTC_2731 amoxapine 43.43 µM -0.456716686958197 0.320221644470814 no 2284 0.323937347596621 757 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_924 2046-0044 21.3 µM -0.457046806249867 0.320087325817561 no 2285 0.323818701500832 739 3623589
SGTC_1438 4092-1045 4 µM -0.457826096014136 0.319770342613464 no 2286 0.323538692894494 736 1351342
SGTC_2250 alverine citrate 130 µM -0.458200944562256 0.31961791640919 no 2287 0.323404040669622 735 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2985 9022375 71.43 µM -0.458697332711414 0.319416114944165 no 2288 0.323225764862055 767 4939335
SGTC_3074 9116018 49.47 µM -0.461112231640772 0.318435126559691 no 2289 0.322359043290715 774 17027303
SGTC_2038 4100038 30.985 µM -0.461612814947813 0.318231936813246 no 2290 0.322179501535194 730 3596803
SGTC_2257 7960413 200 µM -0.462818890975527 0.317742608043568 no 2291 0.321747094615645 736 2974689 YIL048W NEO1
SGTC_3121 9125696 49.47 µM -0.46287331516068 0.317720534577291 no 2292 0.321727587938118 757 1235365
SGTC_3138 9097216 49.47 µM -0.462967518490292 0.317682328939892 no 2293 0.321693824809509 760 25237486
SGTC_1264 0783-0040 158 µM -0.463622886475984 0.317416587928578 no 2294 0.321458977133094 728 2855798
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.465259301894579 0.316753459169334 no 2295 0.320872887917765 776 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1723 st034307 2.5525 µM -0.46563476427613 0.316601392509932 no 2296 0.320738477320216 733 867466
SGTC_3311 9131146 2.8755 µM -0.466045033739817 0.31643526401006 no 2297 0.320591633110364 739 4900406 YPR165W RHO1
SGTC_725 1497-0963 19 µM -0.466570009332076 0.316222742106535 no 2298 0.320403774073802 751 3549977
SGTC_1484 3473-2379 286 µM -0.468415788956499 0.315476011303868 no 2299 0.319743639589489 749 671917
SGTC_508 roscovitine 141 µM -0.468486873271794 0.315447268386641 no 2300 0.319718228012589 752 160355 A CDKinase inhibitor.
SGTC_2364 9055074 200 µM -0.470062304212568 0.314810530341821 no 2301 0.31915525246584 778 6470630
SGTC_2929 9013348 24.6 µM -0.470211918975429 0.314750089486916 no 2302 0.319101809728151 737 2995952
SGTC_1027 k015-0025 8.67 µM -0.470706669038665 0.314550257410176 no 2303 0.318925110643779 737 3598955
SGTC_1163 k060-0048 49.9 µM -0.470817028118992 0.314505690221091 no 2304 0.318885701710511 724 6809982
SGTC_949 1165-0505 146 µM -0.471406689950173 0.31426760818963 no 2305 0.318675169750896 726 6244267
SGTC_2377 9073351 62.6 µM -0.472058625499844 0.314004472421915 no 2306 0.318442471789484 772 7337946 YHR072W ERG7
SGTC_577 r071-0003 38.6 µM -0.474143924107646 0.31316343461128 no 2307 0.31769863900376 746 4568517 YMR134W ERG29
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.47506369967002 0.312792781186666 no 2308 0.317370785544928 729 6708784 An antioxidant flavonoid
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.475690321266033 0.312540371997797 no 2309 0.31714750865806 769 5355888
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.476976305991628 0.312022640439418 no 2310 0.316689496958829 752 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3239 9133757 49.47 µM -0.477333242782086 0.311879005077881 no 2311 0.316562421403692 766 17036923
SGTC_274 sirtinol 40.1 µM -0.479824218908993 0.310877405777928 no 2312 0.315676195048268 726 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3324 9138759 60.749 µM -0.4809347753387 0.310431311549835 no 2313 0.315281428073562 745 45595710
SGTC_1979 st071809 45.3 µM -0.481585803850108 0.31016993247127 no 2314 0.315050106425554 783 4976333
SGTC_3286 9117135 37.221 µM -0.481858871809988 0.310060327938463 no 2315 0.314953102256209 753 3438150
SGTC_3134 9127454 49.47 µM -0.482107033903343 0.309960734805285 no 2316 0.314864956671756 760 24262820
SGTC_2816 7982706 58.44 µM -0.482785811099837 0.309688397208102 no 2317 0.314623913243926 765 2981853
SGTC_2981 9013952 38.96 µM -0.482836984071804 0.309667869924945 no 2318 0.314605744194867 725 2996344
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.485808247595649 0.308477010954802 no 2319 0.313551563072323 750 75037 A free radical scavenger.
SGTC_2001 4023502 57.655 µM -0.488293163096528 0.307482620579462 no 2320 0.312671101741184 747 108941 YCR052W RSC6
SGTC_1378 2093-0007 380 nM -0.489335291697557 0.307066011412302 no 2321 0.312302169724626 787 3618014
SGTC_499 genistein 192 µM -0.489405880731311 0.307037801206108 no 2322 0.312277186752334 768 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2729 fluphenazine 10.66 µM -0.489882516159675 0.306847348493889 no 2323 0.312108517849811 764 3372 An atypical antipsychotic.
SGTC_740 k014-0057 261 µM -0.490348459864854 0.306661218331166 no 2324 0.311943670534025 766 4012779
SGTC_2845 9003024 42.97 µM -0.49216099522695 0.305937640727387 no 2325 0.311302767831071 740 2990173
SGTC_943 3253-1379 105 µM -0.49411949648397 0.305156642957691 no 2326 0.310610894777818 770 668464
SGTC_3229 9132204 49.47 µM -0.494492254260826 0.305008097455653 no 2327 0.31047928765659 755 17682924
SGTC_3187 9109394 49.47 µM -0.496173642675096 0.304338456808591 no 2328 0.309885952646188 743 17098090
SGTC_1683 st010134 710 nM -0.496341615748342 0.304271594741931 no 2329 0.309826704805404 783 3818134
SGTC_2838 9002687 71.43 µM -0.496706999056361 0.30412617567699 no 2330 0.309697843041752 766 6457060
SGTC_3159 9100096 49.47 µM -0.496817331752639 0.30408227040669 no 2331 0.309658935992275 729 25236875
SGTC_1762 st045503 25.4615 µM -0.497258085822443 0.303906907010463 no 2332 0.309503532443544 755 4645554
SGTC_2896 9052656 71.43 µM -0.497994616672869 0.303613963225737 no 2333 0.309243918270259 769 6469436
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.498268348892767 0.303505122600152 no 2334 0.309147456737342 768 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1078 idebenone 36.1 µM -0.498919488484233 0.303246288389962 no 2335 0.308918052069833 764 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_952 1185-0122 232 µM -0.499609525812584 0.302972099715654 no 2336 0.30867502456561 753 678600
SGTC_3113 9123498 49.47 µM -0.499743581843096 0.30291884497056 no 2337 0.308627820454541 772 8897275
SGTC_1181 1222-0449 220 µM -0.499825425333714 0.302886334101434 no 2338 0.308599003095097 773 658318
SGTC_2420 aureobasidin a 50 nM -0.499951048981883 0.302836435383521 no 2339 0.308554772893075 747 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2231 micatex 6.853 µM -0.500124892622552 0.302767389370808 no 2340 0.308493569736997 760 20737 An antifungal of unknown mechanism.
SGTC_2019 4016004 108 µM -0.50030366748792 0.302696392162746 no 2341 0.30843063605019 759 45595336
SGTC_2793 7325131 81.82 µM -0.501500864839887 0.302221139201993 no 2342 0.308009334669557 747 4176441
SGTC_3267 9137951 49.47 µM -0.502455484006851 0.301842422956375 no 2343 0.307673579283383 762 16643986
SGTC_1226 3909-7979 35.4 µM -0.503830684014007 0.30129722926746 no 2344 0.307190181740279 761 6615510
SGTC_2597 laccaic acid a 100 µM -0.504081765559364 0.30119773667557 no 2345 0.307101960011135 762 5491415 A textile dye.
SGTC_3244 9134489 49.47 µM -0.504487569377034 0.301036965739365 no 2346 0.306959397613235 785 16584271
SGTC_1323 1348-1351 11.2 µM -0.505387728887156 0.300680479619684 no 2347 0.306643267965219 766 6989654
SGTC_2421 5690543 90.72 µM -0.506540948698439 0.300224053794802 no 2348 0.306238475455349 778 3397993
SGTC_2842 9000675 19.48 µM -0.507347867562451 0.299904874692259 no 2349 0.305955378835256 742 2989072
SGTC_1975 st070967 30.8 µM -0.507909252909793 0.299682907724916 no 2350 0.305758492685267 772 261391
SGTC_236 1509-0011 5.31 µM -0.508524934108169 0.299439558243153 no 2351 0.305542628714901 798 3107280
SGTC_3292 9120825 59.784 µM -0.508838542789197 0.299315638104749 no 2352 0.305432700355199 787 24824900
SGTC_887 0885-0007 9.62 µM -0.510195945384387 0.298779539013398 no 2353 0.304957096250622 762 5719458
SGTC_2299 7976368 114.88 µM -0.51040377591612 0.298697495964382 no 2354 0.304884306039183 762 2979718
SGTC_678 1218-2179 85.9 µM -0.511017924430733 0.298455114958113 no 2355 0.304669252837262 771 6820081 YOR116C RPO31
SGTC_1276 0871-0068 94.2 µM -0.512368963194571 0.297922226708652 no 2356 0.304196404190925 765 3414906
SGTC_548 1436-0017 110 µM -0.512678224246007 0.297800306360983 no 2357 0.304088212237755 776 9677137
SGTC_1040 k898-0338 155 µM -0.513748536747475 0.297378531578982 no 2358 0.303713906334239 786 20969351
SGTC_689 0833-0039 98 µM -0.514366048353453 0.297135314861969 no 2359 0.303498045941561 800 5374726
SGTC_2990 9074105 71.4286 µM -0.514406308069006 0.297119461094382 no 2360 0.303483974937204 779 6502001
SGTC_2854 9024559 71.43 µM -0.516330492969943 0.296362192800059 no 2361 0.302811801237826 785 3163529
SGTC_1070 indatraline 8.81 µM -0.516735692288697 0.296202838343286 no 2362 0.30267033836002 784 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_370 0180-0345 38.7 µM -0.517733261346639 0.295810687725229 no 2363 0.302322194055562 741 3989527
SGTC_3043 9092303 49.47 µM -0.518103507222202 0.295665202471763 no 2364 0.302193026679822 753 25236084
SGTC_645 0845-0943 5.41 µM -0.518887628216787 0.295357196817219 no 2365 0.301919552842237 758 1885106
SGTC_854 0422-0053 192 µM -0.518922606085448 0.295343460820105 no 2366 0.301907356382258 752 3596728
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.520732878161009 0.294632958882159 no 2367 0.301276433678293 792 5393153
SGTC_3304 9125678 46.087 µM -0.520781568145119 0.294613859759604 no 2368 0.301259472268223 775 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1003 4049-0218 100 µM -0.520944041896318 0.294550131974597 no 2369 0.301202876801271 774 295161
SGTC_1734 st037168 69.4 µM -0.5209768063611 0.294537281397029 no 2370 0.301191464336919 771 708907
SGTC_1071 trifluoperazine 6.31 µM -0.522271158261903 0.294029829697906 no 2371 0.300740773764119 792 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3019 9081971 49.47 µM -0.524170859641034 0.293285783045471 no 2372 0.300079853482813 762 16451803
SGTC_1610 st001799 48.1 µM -0.524812337407714 0.293034735857315 no 2373 0.299856827058074 763 621897
SGTC_1840 st055363 71 µM -0.524819336246245 0.29303199735863 no 2374 0.299854394143756 774 676033
SGTC_682 0kpi-0099 17 µM -0.525829103994796 0.292637020907518 no 2375 0.299503475539673 781 1714895 YML126C ERG13
SGTC_2354 9060492 162 µM -0.525897480518291 0.292610283980928 no 2376 0.29947971978252 778 6471895
SGTC_582 0987-0078 156 µM -0.526932542191925 0.292205687739381 no 2377 0.299120217205884 781 1625765
SGTC_1518 st038567 90.8 µM -0.528456189412025 0.291610581864279 no 2378 0.298591373491782 781 77966
SGTC_559 1550-0661 158 µM -0.529413812225654 0.291236843116762 no 2379 0.298259209333475 759 5830875
SGTC_223 busulfan 5 mM -0.531355727562028 0.290479644305471 no 2380 0.297586147364848 771 2478 A DNA alkylator.
SGTC_19 0279-0214 38.434 µM -0.532940451865078 0.289862406369739 no 2381 0.297037401007113 754 3566274 YBR002C RER2
SGTC_538 2922-0838 53.3 µM -0.533225287192607 0.28975153045586 no 2382 0.296938819468726 764 777039
SGTC_2005 4024620 188 µM -0.533985020799702 0.289455891485306 no 2383 0.296675948821837 781 236743
SGTC_2719 novobiocin 32.65 µM -0.534525760759264 0.28924555696525 no 2384 0.296488915733563 782 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1169 aniline yellow 25.8 µM -0.534534642023511 0.289242102972046 no 2385 0.296485844300907 778 6051 A DNA damaging agent.
SGTC_1674 st016616 23.6 µM -0.535198665872685 0.288983913828823 no 2386 0.296256244372831 767 625830
SGTC_963 1269-2853 151 µM -0.535241105878051 0.288967415776407 no 2387 0.296241572639444 735 3668223
SGTC_1626 st003712 1.76 µM -0.538378431563422 0.287749046387718 no 2388 0.295157906836702 798 24207035
SGTC_1781 st038725 66.3 µM -0.539127890571774 0.28745835615763 no 2389 0.294899306028932 751 4270275 YIL048W NEO1
SGTC_1574 spiramycin 23.7 µM -0.541498995169774 0.28653959943224 no 2390 0.294081845030487 776 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.542840395888242 0.286020450565513 no 2391 0.293619848637455 786 140250 A respiratory chain inhibitor.
SGTC_2131 toluylene red 5.2905 µM -0.543182411100366 0.28588815539774 no 2392 0.293502107791659 741 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2648 atorvastatin 78.68 µM -0.545755724840574 0.284893704027393 no 2393 0.292616930698636 794 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_918 glabranin 770.725 nM -0.546420328195018 0.284637137917661 no 2394 0.2923885198921 775 124049 Also referred to as licorice root.
SGTC_1131 3454-3128 32.3 µM -0.546685647856972 0.284534743684421 no 2395 0.292297358019057 758 710982
SGTC_1911 st060208 74.3 µM -0.547471677269514 0.284231496389589 no 2396 0.292027361752994 783 688783
SGTC_3007 9078383 71.4286 µM -0.547733564842279 0.284130495441741 no 2397 0.29193743077638 759 6496995
SGTC_2871 9038510 12.99 µM -0.547762777844255 0.284119230064944 no 2398 0.29192739996674 813 4945164
SGTC_390 dec-rvkr-cmk 16.7 µM -0.547855467188958 0.284083487792387 no 2399 0.291895574475777 763 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.548259853163328 0.283927576223501 no 2400 0.291756744822363 769 641818 YHR062C RPP1
SGTC_871 0574-0004 149 µM -0.548636054042597 0.283782568235475 no 2401 0.291627619020439 783 9551173
SGTC_270 tamoxifen 5.46 µM -0.548935491284145 0.283667174419314 no 2402 0.29152486033254 785 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2762 leflunomide 42.06 µM -0.549082356988665 0.283610585152841 no 2403 0.291474466204493 789 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3122 9126309 49.47 µM -0.550294418548619 0.28314376868338 no 2404 0.291058725932279 806 17591206
SGTC_2889 9059656 51.95 µM -0.550833458367848 0.282936280024364 no 2405 0.290873922898155 774 3949838
SGTC_2033 5192550 145 µM -0.551013443427114 0.282867015952212 no 2406 0.290812229496374 759 182073
SGTC_2349 9023730 187.07 µM -0.551752100325952 0.282582842207114 no 2407 0.290559104479144 788 4126287
SGTC_1256 0570-0116 285 µM -0.552936182711984 0.28212759230703 no 2408 0.290153555036301 789 410638
SGTC_1129 3453-1384 223 µM -0.554405095563006 0.281563323443097 no 2409 0.289650819798577 826 1084452
SGTC_3006 9075424 71.4286 µM -0.555363192669504 0.281195573126288 no 2410 0.28932313165634 785 7465181
SGTC_1526 st051518 75 µM -0.55648522434197 0.280765194236315 no 2411 0.288939596272535 769 673993
SGTC_94 0334-0113 514.748 µM -0.558655731716316 0.279933555642082 no 2412 0.288198348352112 779 6795178
SGTC_2224 6650123 117.647 µM -0.558851362354098 0.279858657702025 no 2413 0.288131582811874 776 2908370
SGTC_2522 biochanin a 4.94 µM -0.559951381978463 0.279437692045757 no 2414 0.287756300046237 780 5280373 A possible chelator.
SGTC_2940 9060638 45.86 µM -0.560122877498183 0.279372090280154 no 2415 0.287697813437661 764 4027022
SGTC_2572 astragaloside iv 100 µM -0.561064059960342 0.279012195293474 no 2416 0.287376933846904 773 45006101 An anti-inflammatory agent.
SGTC_2726 cimetidine 79.27 µM -0.561077348569863 0.279007115530135 no 2417 0.287372404541748 794 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_457 grayanotoxin iii 135 µM -0.561266289478145 0.278934894999909 no 2418 0.287308009356176 796 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1662 st014054 52 µM -0.561538641446121 0.278830807538863 no 2419 0.287215197876989 785 2838777
SGTC_3341 9147222 25.867 µM -0.562937442760273 0.278296511767648 no 2420 0.286738741320074 796 1939759
SGTC_2922 7999257 32.47 µM -0.563011380098672 0.278268284046971 no 2421 0.286713567380167 794 2988377
SGTC_374 0880-0231 82.3 µM -0.566042386054779 0.277112312796197 no 2422 0.285682483594362 785 6833587
SGTC_638 3970-0837 4.09 µM -0.566392246919966 0.276979033571007 no 2423 0.285563582026977 770 4118451 YLR208W SEC13
SGTC_2291 7917025 104.35 µM -0.567009816880664 0.27674384738811 no 2424 0.285353755991483 781 2964612
SGTC_1850 st056238 17 µM -0.567188945319302 0.27667564907996 no 2425 0.285292908919804 792 5393177
SGTC_417 st075190 100 µM -0.569727331547132 0.275710113400078 no 2426 0.284431324733136 794 222757
SGTC_345 1362-0200 395 µM -0.569938551638711 0.275629845509737 no 2427 0.284359688044577 784 1419823
SGTC_162 k030-0015 37.8 µM -0.570839399944911 0.275287634057937 no 2428 0.284054256238204 804 1809920 YMR134W ERG29
SGTC_2181 6316240 54.2555 µM -0.571155445501482 0.275167625228275 no 2429 0.283947138476583 774 12779990
SGTC_2059 5238311 157 µM -0.572068016734081 0.274821248293693 no 2430 0.283637947972997 784 703021
SGTC_2920 7982904 15.77 µM -0.572956431732723 0.274484246732438 no 2431 0.283337096921762 788 6456808
SGTC_1937 st074714 47.2 µM -0.57344524983436 0.274298910864359 no 2432 0.283171629835887 777 17250970
SGTC_3201 9113999 49.47 µM -0.573733043570076 0.274189822489374 no 2433 0.283074232073398 790 16649224
SGTC_677 0929-0063 136 µM -0.574278961751113 0.273982950794087 no 2434 0.282889521685827 810 1539583
SGTC_679 0422-0091 41.4 µM -0.57497620378064 0.273718848263843 no 2435 0.282653695361808 808 627384 YHR062C RPP1
SGTC_1116 jasmonic acid 1.58368 µM -0.575050801497948 0.273690599471642 no 2436 0.282628469969709 811 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1826 st055655 41.6 µM -0.575363167187224 0.273572327959485 no 2437 0.282522854536423 786 676168
SGTC_1244 0416-0015 52.5 µM -0.575910537073214 0.273365137451776 no 2438 0.282337826502565 775 96201
SGTC_3072 9116419 49.47 µM -0.577261625379741 0.272854056209888 no 2439 0.28188136637103 780 17170162
SGTC_1225 1216-0074 20.6 µM -0.581324805890695 0.271319923208037 no 2440 0.28051078262796 801 4241466
SGTC_2031 5180455 200 µM -0.581929448368455 0.271091996647693 no 2441 0.280307101894323 806 29949
SGTC_781 4335-2806 94.4 µM -0.581997011289671 0.271066534002071 no 2442 0.280284347001394 818 845254
SGTC_3092 9117248 49.47 µM -0.582709392348479 0.27079812938269 no 2443 0.280044474679377 797 17141857
SGTC_901 1112-0062 60.1 µM -0.583622538876703 0.270454276259018 no 2444 0.279737146387527 785 1908457
SGTC_280 3448-3607 3.04 µM -0.584186416306766 0.270242052415156 no 2445 0.279547449751458 787 626179
SGTC_460 trequinsin 123 µM -0.584696107937072 0.270050293900938 no 2446 0.279376035772282 807 5537 A vasodilator.
SGTC_599 1935-0052 86.5 µM -0.586403350086955 0.269408483793893 no 2447 0.278802246783058 781 9557311
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.586556020891285 0.26935112694246 no 2448 0.278750963427161 787 2724278 An inhibitor of dopamine biosynthesis.
SGTC_3312 9133330 71.43 µM -0.587500572822697 0.26899640467352 no 2449 0.278433782931058 810 17617324
SGTC_1857 st056007 79.3 µM -0.589085429645421 0.268401746042414 no 2450 0.277901983493987 780 619834
SGTC_68 0986-0284 82.829 µM -0.589235053405341 0.268345639456858 no 2451 0.277851802796175 781 423278 YIL048W NEO1
SGTC_431 k089-0097 107 µM -0.592148272709793 0.267254404387753 no 2452 0.276875652120781 798 5499420
SGTC_1843 st055809 45.5 µM -0.59334745726486 0.26680586478519 no 2453 0.276474322342304 797 16413835
SGTC_2465 5809242 33.21 µM -0.594971387241511 0.266199061582849 no 2454 0.275931298575645 832 2731748
SGTC_441 propafenone 146 µM -0.595589340154265 0.265968338848492 no 2455 0.275724799824962 802 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_145 3737-0113 38.366 µM -0.597304953593181 0.265328318274649 no 2456 0.275151898912425 797 6849351
SGTC_2080 5212524 12.4 µM -0.597458866244192 0.265270938411129 no 2457 0.275100530978032 807 260183
SGTC_2624 nerol 100 µM -0.598910408226875 0.264730102030499 no 2458 0.274616315172275 823 637566 A natural product oil.
SGTC_658 3253-0951 102 µM -0.601759840356161 0.263670052795204 no 2459 0.273667005442538 796 1184878
SGTC_3015 9080845 49.47 µM -0.601930993884177 0.263606449055288 no 2460 0.273610036087559 801 5296973
SGTC_3169 9102970 49.47 µM -0.603485392694789 0.263029165006825 no 2461 0.273092915055097 805 17027839
SGTC_2071 5230951 39.92 µM -0.604746891673909 0.262561135684947 no 2462 0.272673593010781 809 1799272
SGTC_104 0074-0074 590.992 µM -0.604828013987503 0.262531053050271 no 2463 0.272646638906043 785 3943124
SGTC_2301 7769476 200 µM -0.604870647216878 0.26251524405229 no 2464 0.27263247390663 803 977820
SGTC_614 0462-0418 107 µM -0.606433417770256 0.261936083369357 no 2465 0.272113491631346 781 5188303
SGTC_1560 lithocholic acid 53.1 µM -0.60671214841924 0.261832855052895 no 2466 0.272020979286461 795 9903 A bile acid which acts as a detergent.
SGTC_1994 st072947 40.9 µM -0.606840844460884 0.261785199322034 no 2467 0.271978269590518 820 5286565 YDL195W SEC31
SGTC_38 0929-0051 58.268 µM -0.606891788500318 0.261766336137196 no 2468 0.271961363974627 800 1379719
SGTC_2315 7733312 200 µM -0.607288285071851 0.261619548134386 no 2469 0.271829805727105 788 726316
SGTC_1836 st055642 81 µM -0.608383415518614 0.261214336706072 no 2470 0.271466604149823 805 8571
SGTC_3112 9123419 49.47 µM -0.608993600341978 0.260988700973282 no 2471 0.271264340406136 827 17015854
SGTC_1670 st016595 4.04 µM -0.609592808182127 0.260767221907346 no 2472 0.271065788438116 823 597879
SGTC_1160 4092-0570 10.5 µM -0.609604152914683 0.26076302960285 no 2473 0.271062029976018 809 4994975
SGTC_2314 7727897 200 µM -0.610081689516746 0.260586593362234 no 2474 0.270903847689988 782 900724
SGTC_1004 4084-0029 199 µM -0.610707890505336 0.260355323012095 no 2475 0.270696490690228 790 716894 YLR208W SEC13
SGTC_261 5-fluorouridine 15.376 µM -0.611356068471009 0.26011604747673 no 2476 0.270481939853172 782 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3334 9142812 21.919 µM -0.611729759028914 0.259978150774196 no 2477 0.270358284638597 787 45283678
SGTC_2614 arthonioic acid 13.39 µM -0.612395740096143 0.25973248855134 no 2478 0.27013797978329 807 6710684
SGTC_1268 0828-0275 2.46 µM -0.613166293762607 0.259448401922696 no 2479 0.269883194677417 805 745337
SGTC_1645 Cervolide 78 µM -0.614932780049461 0.258797742505926 no 2480 0.269299556826144 796 23173 A fragrance.
SGTC_1223 0764-0573 147 µM -0.61508121550706 0.25874310695845 no 2481 0.269250543368933 799 1609797
SGTC_907 3448-6986 75.5 µM -0.615660016705422 0.258530121097843 no 2482 0.269059465692987 812 590582
SGTC_1947 st076332 61.6 µM -0.616183600646058 0.258337532197922 no 2483 0.268886675347287 818 24208416
SGTC_1287 0971-0001 34.6 µM -0.616244561464098 0.258315113927188 no 2484 0.26886656100916 791 4665869
SGTC_1619 st003326 88.7 µM -0.617804604539848 0.257741753091489 no 2485 0.26835207392643 776 2849032
SGTC_2472 5377652 49.4 µM -0.618022890421244 0.257661579449532 no 2486 0.268280124867616 829 1610903
SGTC_1195 1502-0147 41.1 µM -0.618585847847459 0.257454872085146 no 2487 0.268094613656416 796 817940
SGTC_1243 0416-0003 5.65 µM -0.61865435281043 0.257429724233876 no 2488 0.268072043641602 809 2141977
SGTC_260 nsc-65238 3.989 µM -0.618740856098476 0.257397971105059 no 2489 0.268043545167971 788 3246252
SGTC_209 4077-0173 175.592 µM -0.620328232467083 0.25681564765468 no 2490 0.267520855600804 785 15993494
SGTC_3196 9111891 49.47 µM -0.620639540253978 0.256701525961333 no 2491 0.267418408822369 831 18891510
SGTC_519 k048-0011 62.8 µM -0.621000581505454 0.256569205652673 no 2492 0.267299620285499 792 6836379
SGTC_2580 diallyl disulphide 81.36 µM -0.621306232510952 0.256457213442405 no 2493 0.267199076869615 805 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_479 n-linoleoylglycine 10 µM -0.621740942152394 0.256297977320327 no 2494 0.267056112706046 820 6433346 An anti-infammatory.
SGTC_3347 9188721 44.724 µM -0.621930665478969 0.256228496959548 no 2495 0.266993729979592 812 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_526 4469-0568 170 µM -0.622620094749171 0.255976097297132 no 2496 0.266767101450578 789 2901964
SGTC_3153 9100258 49.47 µM -0.623235888191552 0.255750765394235 no 2497 0.266564760651018 818 25236848
SGTC_2817 7995342 71.43 µM -0.624242249542291 0.255382739425683 no 2498 0.266234252041236 817 18879975
SGTC_1272 0839-0021 27 µM -0.624429313672494 0.255314360661675 no 2499 0.266172839419355 815 5027250
SGTC_881 0833-0569 170 µM -0.624988673987286 0.255109951168656 no 2500 0.265989245817158 779 5418700
SGTC_1497 4476-2978 41.3 µM -0.628123617233355 0.253965921221813 no 2501 0.264961481387391 808 1528379
SGTC_1229 0139-0193 12.2 µM -0.628777170350509 0.253727760673968 no 2502 0.264747474046408 800 3090752
SGTC_1852 st056254 31.4 µM -0.629243883693375 0.253557757999933 no 2503 0.264594701592942 811 442583
SGTC_1710 st031758 61.5 µM -0.629413871750576 0.253495853868265 no 2504 0.264539069389581 809 5394341
SGTC_1365 1672-3266 55.4 µM -0.629647413500136 0.253410818496625 no 2505 0.264462647596097 810 6415873
SGTC_11 0438-0307 1.3 µM -0.629690942273908 0.253394970802079 no 2506 0.26444840493141 819 4011476
SGTC_2617 dihydrotanshinone i 20.83 µM -0.630404039708621 0.253135424754255 no 2507 0.264215134227339 810 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1813 st051246 8.6015 µM -0.630552886044637 0.253081266803631 no 2508 0.264166456363179 798 5291959
SGTC_1236 0330-0013 258 µM -0.633465336037622 0.252022795429246 no 2509 0.263214905230558 814 4617066
SGTC_1187 1391-0724 117 µM -0.634386153959569 0.25168862932207 no 2510 0.26291442173138 809 6997986
SGTC_2752 diclazuril 33.15 µM -0.636439433023854 0.250944334971259 no 2511 0.262245022934966 799 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_648 0375-0473 33.3 µM -0.636475340454536 0.250931329236846 no 2512 0.262233324363692 806 1713139
SGTC_2850 9015429 58.44 µM -0.63813770235615 0.250329609605894 no 2513 0.261692022931473 837 6457570
SGTC_2695 st077686 51.995 µM -0.638250418711721 0.250288837749845 no 2514 0.261655340784713 799 2876092
SGTC_780 0109-0199 192 µM -0.640976091551282 0.249303977990578 no 2515 0.260769108298448 820 610414
SGTC_2203 7227154 166.4 µM -0.641146961952531 0.249242306568452 no 2516 0.260713602532447 803 896304
SGTC_195 4234-0266 16.654 µM -0.641732242367465 0.249031125655524 no 2517 0.260523525361812 817 2303354
SGTC_3170 9103054 49.47 µM -0.642019235606692 0.248927607536197 no 2518 0.260430346779533 819 16432970
SGTC_835 0312-0010 67.2 µM -0.643426804901759 0.248420230751411 no 2519 0.2599735975221 815 1626196
SGTC_562 3772-2733 112 µM -0.643686043201836 0.248326845051756 no 2520 0.259889521051761 801 2876874 YIL048W NEO1
SGTC_3120 9124077 49.47 µM -0.64382476533455 0.248276880712223 no 2521 0.259844536288276 825 18774327 YGL155W CDC43
SGTC_2193 5925765 200 µM -0.643839339040921 0.248271631928662 no 2522 0.259839810565193 809 877370
SGTC_175 3793-3120 23.7 µM -0.644013843673627 0.24820878792411 no 2523 0.259783228502113 844 5322297
SGTC_2673 kobusone 100 µM -0.646369225039512 0.247361379768571 no 2524 0.259020132987825 834 6710676 An epoxy ketone and protein crosslinker.
SGTC_581 0958-0271 211 µM -0.648486777912335 0.246600858563171 no 2525 0.258335079961885 806 4591145
SGTC_2030 5175110 200 µM -0.649097940442019 0.246381592074441 no 2526 0.258137536499084 840 2831986
SGTC_914 3820-6779 408 µM -0.649464089431899 0.246250279046867 no 2527 0.258019225248083 797 2893481
SGTC_186 3455-3465 67.277 µM -0.649606416828896 0.246199245907429 no 2528 0.257973243549512 820 755278
SGTC_1167 k781-0610 148 µM -0.650703415261912 0.245806094775518 no 2529 0.257618979066166 802 4525169
SGTC_809 3998-0021 90 µM -0.654322804788759 0.244511342649323 no 2530 0.256451928308374 821 715485
SGTC_2813 7971799 71.43 µM -0.654401624003039 0.244483187848106 no 2531 0.256426544200194 815 2234054
SGTC_621 3584-0052 32.1 µM -0.655144860350575 0.244217784283156 no 2532 0.256187245743075 830 2273927
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.655185118390843 0.244203412905342 no 2533 0.256174287260132 811 688667
SGTC_2657 nystatin 74.44 µM -0.655266956290883 0.244174199690168 no 2534 0.256147945873234 807 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_17 0960-0276 49.807 µM -0.656245546915307 0.243825023723272 no 2535 0.255833073714392 815 6821114
SGTC_1237 0330-0133 46.1 µM -0.656258406543442 0.243820437007715 no 2536 0.255828937334677 836 X1237 YHR072W ERG7
SGTC_3079 9117512 49.47 µM -0.656551885875148 0.243715772751226 no 2537 0.255734547364113 865 7185044
SGTC_2397 5161689 200 µM -0.656892913854872 0.243594181578755 no 2538 0.255624887455711 827 2259942
SGTC_839 0122-0028 230 µM -0.656922246837067 0.243583724636735 no 2539 0.255615456379303 838 759448
SGTC_1902 st060212 70.5 µM -0.657984758207184 0.243205112456858 no 2540 0.255273962591433 803 688944
SGTC_93 0109-0045 59.227 µM -0.658043727933572 0.243184108680513 no 2541 0.255255016563632 830 88733
SGTC_2229 7354935 190 µM -0.66026265460557 0.242394486854822 no 2542 0.254542645620801 829 318112
SGTC_659 k018-0002 107 µM -0.660409675169079 0.242342217590126 no 2543 0.254495482511435 821 6797879 YHR007C ERG11
SGTC_3066 9117245 49.47 µM -0.660455769418529 0.24232583125912 no 2544 0.254480696759975 815 17176980
SGTC_1344 1488-0097 29.1 µM -0.660609905613304 0.242271040787011 no 2545 0.254431257430792 837 747966
SGTC_2897 9048598 12.99 µM -0.660934884754633 0.242155543133159 no 2546 0.254327036562066 825 6467404
SGTC_3036 9090181 49.47 µM -0.660936648265497 0.242154916462479 no 2547 0.254326471064873 831 25236586
SGTC_1731 st035964 63 µM -0.661731933170686 0.241872398394613 no 2548 0.254071517774929 833 6739575
SGTC_1252 0493-0875 34.8 µM -0.66283324298256 0.241481463108146 no 2549 0.253718680203417 804 3960963
SGTC_572 0960-0087 17.7 µM -0.66315841985835 0.241366099744249 no 2550 0.253614549279047 839 6796365
SGTC_3305 9127027 53.8275 µM -0.663188940221822 0.24135527353803 no 2551 0.253604776939327 824 41905295
SGTC_1814 st052110 31.539 µM -0.663853554806209 0.241119586393542 no 2552 0.253392022521234 829 674163
SGTC_299 1273-0059 1.44 µM -0.664613733907511 0.24085016341736 no 2553 0.253148791340697 816 2848077
SGTC_1364 1653-0028 37.6 µM -0.666348706844434 0.240235867580373 no 2554 0.252594119942253 810 5718652
SGTC_2226 7298446 200 µM -0.666778243411033 0.240083915023682 no 2555 0.252456895904156 831 3283010
SGTC_2844 9010103 25.97 µM -0.666974240276769 0.240014596721678 no 2556 0.252394293844908 844 2480525
SGTC_509 pifithrin 175 µM -0.667158507500724 0.239949436801449 no 2557 0.252335445735913 836 4817 A p53 inhibitor.
SGTC_2318 6029776 164 µM -0.667490679865245 0.23983199956565 no 2558 0.252229380492144 837 818325
SGTC_830 4076-0286 57.8 µM -0.667908044838237 0.239684487533337 no 2559 0.252096145914342 823 6866659
SGTC_3070 9117005 49.47 µM -0.670686522775606 0.238703735056351 no 2560 0.251210125125199 825 8779016
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.67093547926486 0.238615965231738 no 2561 0.251130816578068 815 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_493 zm226600 134 µM -0.673100446074852 0.237853449450388 no 2562 0.250441695077592 839 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2865 9030313 51.95 µM -0.673185453637822 0.237823536506924 no 2563 0.250414657139891 827 42562754
SGTC_3145 9085516 49.47 µM -0.674222155370372 0.237458902075036 no 2564 0.250085043040044 833 25236195
SGTC_1837 st055472 66.5 µM -0.674478596471843 0.237368752571553 no 2565 0.250003544405593 813 676091
SGTC_1046 2001-0062 216 µM -0.674671000427938 0.237301127076768 no 2566 0.249942406443357 836 739778
SGTC_1849 st056239 19.2 µM -0.675761327618729 0.236918102488889 no 2567 0.249596095825783 821 5393181
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.676163879687257 0.236776774613036 no 2568 0.249468301365575 825 15053
SGTC_1934 st074720 32.6 µM -0.67631860707314 0.236722465300008 no 2569 0.249419190754434 830 17250992
SGTC_962 1254-0300 21.5 µM -0.67711033752948 0.236444675161457 no 2570 0.249167975234689 799 7340576
SGTC_3109 9122853 49.47 µM -0.677521093442477 0.236300626200643 no 2571 0.249037695710759 863 1234709
SGTC_1338 1486-1223 76 µM -0.677619211913454 0.236266223953881 no 2572 0.249006580821879 821 3444526
SGTC_2658 polymyxin b sulfate 77.05 µM -0.677756713615509 0.236218017820471 no 2573 0.248962980380462 825 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1663 st014140 55.4 µM -0.678277536440075 0.236035473901631 no 2574 0.248797869415023 818 4207120
SGTC_1390 3413-2614 145 µM -0.678421104003621 0.23598516837551 no 2575 0.248752365957312 848 3421432
SGTC_2893 9048488 25.97 µM -0.680795364460683 0.235154093944052 no 2576 0.248000491815104 842 6467338
SGTC_2993 9054257 71.4286 µM -0.681699870457788 0.234837910828129 no 2577 0.247714374698534 832 6470217 YGL055W OLE1
SGTC_3054 9094397 49.47 µM -0.68255469216433 0.234539311675982 no 2578 0.247444136022617 836 2598354
SGTC_2826 7992541 19.48 µM -0.684100169535669 0.233999991966352 no 2579 0.246955957411787 883 2985066
SGTC_1387 3342-1166 1.8 µM -0.684368195653237 0.233906529799843 no 2580 0.24687134696984 823 3418228
SGTC_1366 1683-0113 21.9 µM -0.684583645969422 0.233831416099285 no 2581 0.246803344899268 830 708623
SGTC_1757 st041620 31.8375 µM -0.686845888774648 0.233043524770446 no 2582 0.246089924423206 841 5289815
SGTC_1189 1431-2119 7.28 µM -0.687211944698083 0.232916173948032 no 2583 0.245974589160417 844 3107275
SGTC_972 1319-0219 195 µM -0.688672115450676 0.232408565526238 no 2584 0.245514813827568 840 23903702
SGTC_3008 9078912 71.4286 µM -0.688902177129953 0.232328643874 no 2585 0.245442414642531 832 16648731
SGTC_1166 k206-0078 225 µM -0.6891753189115 0.232233776382453 no 2586 0.245356473276472 820 5404595
SGTC_138 0850-0259 40.9225 µM -0.689249606599744 0.232207978542103 no 2587 0.24533310218639 825 6813004
SGTC_3303 9125618 40.5795 µM -0.689614557227286 0.232081265524096 no 2588 0.245218305198744 823 22695467
SGTC_3338 9144300 39.5675 µM -0.689857269456904 0.231997015717905 no 2589 0.245141974885337 815 4901274
SGTC_1550 gossypolone 36.6 µM -0.690562206139014 0.231752416023542 no 2590 0.24492035255886 835 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_632 0781-2353 4.65 µM -0.690565463100222 0.231751286253162 no 2591 0.244919328865655 844 6811515 YHR007C ERG11
SGTC_589 1227-0070 34.1 µM -0.691098684123446 0.231566364632079 no 2592 0.244751763586847 821 2841384
SGTC_2529 gangaleoidin 93.61 µM -0.69141549759536 0.231456532344533 no 2593 0.244652233849652 843 4565183
SGTC_476 mead acid 10 µM -0.696079114998189 0.229843123307594 no 2594 0.243189642516887 850 5312531 An omega 9 fatty acid.
SGTC_3323 9138564 53.9225 µM -0.696671585685589 0.229638605920105 no 2595 0.243004172442677 833 43912313 YNL103W MET4
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.69698012447139 0.229532140529768 no 2596 0.242907616178406 825 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_47 0149-0135 24.25 µM -0.697087388352915 0.229495134188 no 2597 0.242874053139845 829 5239155
SGTC_2725 haloperidol 53.21 µM -0.697552615765749 0.229334668120651 no 2598 0.24272851179323 831 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2697 mebhydrolin 72.4 µM -0.698797062045953 0.228905743468465 no 2599 0.242339432432102 846 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_3087 9117406 49.47 µM -0.700512732042493 0.228315140504486 no 2600 0.241803578361024 820 42546093
SGTC_2243 6634756 200 µM -0.700684061735939 0.228256208968653 no 2601 0.241750102404538 801 885676
SGTC_2680 butyl paraben 22.24 µM -0.700938261261958 0.228168788810267 no 2602 0.241670772686142 862 7184 An antifungal and steroid mimetic.
SGTC_2411 st077133 39.94 µM -0.703140073463849 0.22741236561307 no 2603 0.240984230347495 850 1403142 YNL221C POP1
SGTC_1726 st035556 14.5795 µM -0.703179580930534 0.227398805904607 no 2604 0.240971921303461 823 5919439
SGTC_2323 6148992 148.28 µM -0.703329302272097 0.227347422847356 no 2605 0.240925276855521 844 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_824 1304-0008 100 µM -0.703460251217589 0.227302487675664 no 2606 0.240884484819018 831 768245
SGTC_554 4483-2211 187 µM -0.704131885493419 0.227072094838014 no 2607 0.240675322423065 838 747107
SGTC_666 0272-0154 136 µM -0.704191374544274 0.227051694469318 no 2608 0.240656800928195 836 6870312
SGTC_2433 5607874 27.82 µM -0.70448667234294 0.226950444342721 no 2609 0.240564873534257 842 2252428
SGTC_2363 9053361 176 µM -0.70481063344636 0.226839395592956 no 2610 0.240464045134458 839 6469797 YMR079W SEC14
SGTC_1087 pterostilbene 9.05 µM -0.705709749621596 0.226531353416655 no 2611 0.24018432831445 855 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3147 9097027 49.47 µM -0.706823823257502 0.226149993440654 no 2612 0.239837983943162 863 25236841
SGTC_480 am 92016 50 µM -0.707784963728332 0.225821275932002 no 2613 0.239539402640988 871 2129 K+ channel blocker.
SGTC_1547 harmine 94.2 µM -0.707939829058477 0.225768336075836 no 2614 0.239491312230953 828 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2388 9080168 200 µM -0.708194021876706 0.225681456887195 no 2615 0.239412389034254 856 15943073
SGTC_2070 5230947 200 µM -0.708892126292613 0.225442952886265 no 2616 0.239195710792271 862 2835538
SGTC_395 anisomycin 6.25 µM -0.709047537447522 0.225389876841022 no 2617 0.239147488733254 851 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1677 st019204 53.9 µM -0.710039830568001 0.225051155562341 no 2618 0.238839718387354 832 3945625
SGTC_879 0831-1030 162 µM -0.710303921632436 0.224961056163256 no 2619 0.2387578442299 840 1549252
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.710432489364597 0.224917200377849 no 2620 0.238717990905016 818 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2875 9039966 71.43 µM -0.710454136230192 0.224909816884436 no 2621 0.238711281184594 852 6463691
SGTC_674 0498-0004 451 µM -0.710660845929245 0.2248393175374 no 2622 0.238647214090415 832 4231473
SGTC_2400 5203494 178.7 µM -0.710662054086218 0.224838905526427 no 2623 0.238646839664885 853 6777674
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.710820305305792 0.224784941703766 no 2624 0.238597798074491 853 23847180
SGTC_2979 9012552 45.46 µM -0.711727306695499 0.224475795038212 no 2625 0.238316827423607 854 17100905
SGTC_1108 betulinic acid 729.144 nM -0.711884051882458 0.224422393724659 no 2626 0.238268289312879 818 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3320 9137005 35.139 µM -0.713097376593351 0.224009271701253 no 2627 0.237892751377208 830 4908713
SGTC_1012 4112-3522 18 µM -0.713968911138367 0.223712791815677 no 2628 0.237623201841262 826 3112398
SGTC_1664 st014217 9.02 µM -0.714333920046414 0.223588688869219 no 2629 0.23751036114 849 3982782
SGTC_1671 st016596 74.5 µM -0.71459263101465 0.223500750913664 no 2630 0.237430399736245 847 2829167
SGTC_1709 st033179 39.1045 µM -0.714623225051423 0.223490353053529 no 2631 0.237420944824814 845 573381
SGTC_700 3453-2283 142 µM -0.715173802816259 0.223303277662516 no 2632 0.237250827264998 849 565664
SGTC_3243 9134147 49.47 µM -0.715351926100998 0.223242773992934 no 2633 0.23719580505593 848 24282180
SGTC_2467 5474540 200 µM -0.716647457622828 0.222802997760468 no 2634 0.236795826880245 823 5413519
SGTC_2776 terbinafine 19.92 µM -0.718307248655946 0.222240293402856 no 2635 0.236283930857046 819 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1796 st049173 110.4 µM -0.719049014369243 0.221989081511974 no 2636 0.236055360111625 856 94134
SGTC_2041 5107442 45.335 µM -0.719095409727773 0.221973374304322 no 2637 0.236041067703924 842 793005
SGTC_1019 4262-0212 3.4 µM -0.719545225301785 0.221821121574398 no 2638 0.235902523662131 844 4677213
SGTC_392 N-ethylmaleimide 8.33 µM -0.719953789804668 0.221682883140163 no 2639 0.235776723882785 833 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1539 benzyladenosine 56 µM -0.720267714202444 0.221576699782826 no 2640 0.235680089568088 825 92208 A nucleotide analog.
SGTC_2810 7959871 45.46 µM -0.722396328938192 0.220857473741077 no 2641 0.235025421643385 841 2974535
SGTC_2106 5357045 167.29 µM -0.723879574072142 0.220357099315897 no 2642 0.234569835508219 837 668842
SGTC_1356 1502-0781 85.8 µM -0.72406665446351 0.220294033719089 no 2643 0.234512407544595 842 567702
SGTC_819 1013-0258 27.7 µM -0.72522029894596 0.219905363982625 no 2644 0.234158445856427 840 5753198
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.725265284120789 0.219890216183859 no 2645 0.234144649481093 834 6708561
SGTC_1565 sinapyl alcohol 95.1 µM -0.72636072212897 0.219521535662558 no 2646 0.233808831679702 841 5280507 A phenol propionate derived from cinnamic acid.
SGTC_777 1315-0167 517 µM -0.726377496170937 0.219515892954024 no 2647 0.233803691500229 835 4221767
SGTC_1056 3448-1962 115 µM -0.72638127907231 0.219514620415373 no 2648 0.233802532289655 848 715507
SGTC_1672 st016598 6.51 µM -0.727347423227866 0.219189755791851 no 2649 0.233506576936682 850 4665860 YNL267W PIK1
SGTC_438 sphingosine 6.67 µM -0.728254376121527 0.218885045808757 no 2650 0.233228942606654 828 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_168 3970-0862 530.542 µM -0.728595352483382 0.218770550660001 no 2651 0.233124611117293 847 3135186
SGTC_833 3852-0053 558 µM -0.729366952780253 0.218511585224195 no 2652 0.232888613582187 866 3123681
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.730611474415038 0.218094269524679 no 2653 0.232508250674716 854 5377381
SGTC_3104 9120930 49.47 µM -0.730803480477532 0.218029926564404 no 2654 0.232449598673004 849 17014836
SGTC_3279 9140807 49.47 µM -0.730935761550236 0.217985604353461 no 2655 0.2324091956236 856 45595718
SGTC_2168 5727979 200 µM -0.731318110948705 0.217857523244148 no 2656 0.232292435335697 850 695210
SGTC_1283 0922-0125 16.4 µM -0.733928667466719 0.216984187970845 no 2657 0.231496107047706 827 3360884
SGTC_2366 9070441 60.58 µM -0.735077004686352 0.21660066506785 no 2658 0.231146299019748 839 6837235
SGTC_1771 st048882 4.1505 µM -0.737047638577129 0.215943425347183 no 2659 0.230546689847174 846 4580403
SGTC_1101 ebselen 5.29 µM -0.737112803711061 0.215921711428109 no 2660 0.230526876765488 848 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_469 w7 172 µM -0.737728042929186 0.215716767623005 no 2661 0.230339863755984 836 45115570 A P450 inhibitor.
SGTC_1880 MG-132 525 µM -0.737773735577651 0.215701551335608 no 2662 0.230325978039797 837 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1955 wogonin 32.4 µM -0.738544800080711 0.215444869995249 no 2663 0.23009172686534 838 5281703 A flavanone.
SGTC_513 4245-1575 41.7 µM -0.738732597335507 0.215382380601596 no 2664 0.230034693819496 840 719745
SGTC_1349 flufenamic acid 69 µM -0.741359593380121 0.214509352672893 no 2665 0.229237718661336 855 3371 A non-steroidal anti-inflammatory.
SGTC_471 1-acyl-paf 4 µM -0.742037085472912 0.214284536315916 no 2666 0.229032433277695 843 16759367
SGTC_1062 mesoridazine 14.2 µM -0.742312487775616 0.214193187076155 no 2667 0.228949013726726 832 4078 A neuroleptic.
SGTC_129 0088-0017 176.636 µM -0.742456612421462 0.214145390855426 no 2668 0.228905365066964 844 182446
SGTC_2951 9072950 58.06 µM -0.742748030426497 0.214048766533223 no 2669 0.228817122360931 857 16488155
SGTC_1357 1503-1303 39.5 µM -0.742970438201156 0.21397504073767 no 2670 0.228749789118101 836 292895
SGTC_2082 5219693 150 µM -0.743822434464342 0.213692749913577 no 2671 0.228491952927434 841 2834649
SGTC_100 0086-0128 49.5915 µM -0.74440810068372 0.213498827759967 no 2672 0.228314809854009 867 93297
SGTC_1047 2043-3044 82 µM -0.745232642127707 0.213225984636573 no 2673 0.228065546454257 884 669592
SGTC_2991 9074669 71.4286 µM -0.745452266286617 0.213153344682079 no 2674 0.227999178687665 849 17333109
SGTC_3046 9092212 49.47 µM -0.74545838032234 0.213151322691775 no 2675 0.227997331255394 871 25236637
SGTC_250 brefeldin a 552.239 µM -0.746734352859831 0.212729587001539 no 2676 0.227611964503208 846 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_3030 9087619 49.47 µM -0.746903944664882 0.212673570054759 no 2677 0.227560772340475 839 25236973
SGTC_2165 5727197 32.143 µM -0.747065290153939 0.212620284899822 no 2678 0.227512075389608 858 1361712
SGTC_2814 7977482 42.97 µM -0.747315519381654 0.212537660869766 no 2679 0.22743656334885 845 6456762
SGTC_2387 9077560 195.08 µM -0.747908070355188 0.212342079276772 no 2680 0.227257804682582 852 5303272
SGTC_1334 1486-0610 236 µM -0.750856366540963 0.211370508428721 no 2681 0.226369551185735 833 3742339
SGTC_3082 9117008 49.47 µM -0.751502531709373 0.211157921887013 no 2682 0.226175138853667 860 41448529
SGTC_235 0330-0087 5 mM -0.751558432186339 0.211139536676135 no 2683 0.226158324458971 858 46494818 YHR062C RPP1
SGTC_1076 itraconazole 331 nM -0.75367040382877 0.210445613944262 no 2684 0.225523578805476 852 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1417 3966-0327 90.4 µM -0.75402002333123 0.210330870040633 no 2685 0.225418599253419 873 651118
SGTC_2390 9097792 176.6 µM -0.754861222878535 0.210054941842876 no 2686 0.225166127333858 835 4497149
SGTC_120 rhodamine 6G 52.259 µM -0.755096560762049 0.209977784980944 no 2687 0.225095523306618 881 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2306 7482397 179.52 µM -0.755591096199587 0.209815703008541 no 2688 0.224947197963611 888 891448
SGTC_1199 1638-0010 4.46 µM -0.757933528230657 0.209048980313933 no 2689 0.224245388625751 854 3111136
SGTC_130 0136-0219 337.655 µM -0.758109387678831 0.208991484826275 no 2690 0.224192750099653 885 234244
SGTC_1111 tnp00062 510.699 nM -0.759166672517228 0.208646012496439 no 2691 0.223876429882987 853 676306
SGTC_396 dithiazanine 1.25 µM -0.759545496497414 0.208522312107576 no 2692 0.223763154451732 850 10578 An antihelmenthic.
SGTC_2818 7996756 12.99 µM -0.760371980392523 0.20825258392161 no 2693 0.223516133478691 885 2241621
SGTC_1775 st081588 35.1725 µM -0.761766474228252 0.20779794910719 no 2694 0.223099696543113 858 1426443 YGL099W LSG1
SGTC_1190 1486-1332 13 µM -0.761804982854485 0.207785402794555 no 2695 0.223088203004785 852 4150046
SGTC_3059 1327-0034 3 µM -0.763170842809235 0.207340687889038 no 2696 0.222680757563061 848 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1945 st075991 56.6 µM -0.763311652517215 0.207294873206208 no 2697 0.222638777187714 865 1084980
SGTC_1777 st045864 34.765 µM -0.763365526287612 0.207277346099716 no 2698 0.222622716696558 884 4691462
SGTC_1480 1070-0044 41.2 µM -0.763880274222306 0.207109923975905 no 2699 0.222469296762465 855 3124987
SGTC_2036 5160441 105 µM -0.764128716888771 0.20702914645729 no 2700 0.222395270336908 853 134534 YIL048W NEO1
SGTC_1900 st060200 72.8 µM -0.767347681213386 0.205984233480088 no 2701 0.221437413102778 866 688945
SGTC_49 0717-0965 32.132 µM -0.767438977601215 0.205954643306794 no 2702 0.221410280761303 874 5889349 YGL099W LSG1
SGTC_3213 9129884 49.47 µM -0.770342016119394 0.20501505164964 no 2703 0.220548519513578 864 17190742
SGTC_263 alizarin 107.927 µM -0.770937531640951 0.204822623718008 no 2704 0.220371979760052 886 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_855 0428-0020 25 µM -0.773573546638737 0.203972143466319 no 2705 0.21959151028768 854 6812414
SGTC_1148 3909-7663 27.7 µM -0.775101806661334 0.203480032824476 no 2706 0.219139752062718 885 4084526
SGTC_1594 piperine 70.1 µM -0.776298558472692 0.203095165107885 no 2707 0.218786362014902 857 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3161 9100388 49.47 µM -0.778494377558033 0.202390135076843 no 2708 0.218138809969995 867 25236368
SGTC_1769 st044406 64.4 µM -0.779404949224729 0.202098200029223 no 2709 0.217870604659382 881 670903
SGTC_2727 riluzole 51.77 µM -0.779973443954469 0.201916064853473 no 2710 0.217703253244449 871 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1889 st059080 5.18 µM -0.780384689880678 0.201784370553442 no 2711 0.217582238405748 858 176925 Isolated from Daphnopsis sellowiana.
SGTC_2268 7933382 153.85 µM -0.780500595985333 0.201747262948111 no 2712 0.217548138434954 869 935025 YOR257W CDC31
SGTC_164 4100-3994 89.624 µM -0.78078220355275 0.201657122667494 no 2713 0.21746530138166 884 4615967
SGTC_1684 st024538 14.6195 µM -0.781203208868669 0.201522407308186 no 2714 0.217341493364041 866 6732859
SGTC_281 1672-3440 14.9 µM -0.781271618315326 0.201500522409746 no 2715 0.217321379558088 858 6833000
SGTC_334 1502-1024 68.5 µM -0.783376746943976 0.200827766125298 no 2716 0.216702953470323 863 3296216
SGTC_904 1141-0088 396 µM -0.785168589017843 0.20025619320644 no 2717 0.216177364717785 870 1378119
SGTC_602 3130-1533 38.1 µM -0.785994305462142 0.199993130390638 no 2718 0.215935411648783 870 720941
SGTC_3273 9137859 49.47 µM -0.786491080067288 0.199834964435736 no 2719 0.215789921396557 906 2377234
SGTC_909 3448-9333 149 µM -0.786636977749613 0.199788526989204 no 2720 0.215747203175549 874 3344074
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.786791827486662 0.199739247314655 no 2721 0.215701869193853 886 442882
SGTC_954 1189-0853 2.85 µM -0.787238258975705 0.199597215045585 no 2722 0.215571202328321 861 2828194
SGTC_1259 0671-0132 43 µM -0.78871693482395 0.199127208254935 no 2723 0.215138733887376 866 X1259
SGTC_2964 9083345 53.42 µM -0.789415847881423 0.198905286409266 no 2724 0.214934498144836 857 17741579
SGTC_1667 st014849 34.6 µM -0.790353373112724 0.19860783361694 no 2725 0.214660712282932 864 5348460
SGTC_2556 citropten 84.59 µM -0.791766676993942 0.19815993580695 no 2726 0.214248367902675 838 2775 A potential DNA crosslinker.
SGTC_2378 9074213 121.43 µM -0.792321891743203 0.197984146656396 no 2727 0.214086505054197 861 657714
SGTC_1462 k081-0014 26.5 µM -0.793019488890657 0.197763410706088 no 2728 0.21388323410156 826 3270634
SGTC_1588 farnesol 29.9 µM -0.79372547493088 0.197540171785317 no 2729 0.213677633188235 860 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_91 0417-1751 58.384 µM -0.794525001849976 0.197287538472834 no 2730 0.213444929897567 876 6795624
SGTC_2924 9010168 62.78 µM -0.796453595583062 0.196678949147444 no 2731 0.212884218585229 878 2993929
SGTC_1756 st041558 35.5 µM -0.79705921271974 0.196488074746797 no 2732 0.212708321500846 899 3955792
SGTC_898 1000-0849 28.3 µM -0.797062743505005 0.196486962266496 no 2733 0.212707296258863 876 6751807
SGTC_529 4076-0302 30.3 µM -0.797209741407496 0.196440649534838 no 2734 0.212664614711112 880 5816522
SGTC_2877 9040724 71.43 µM -0.798369668877575 0.196075438268726 no 2735 0.212327999659977 882 6463895
SGTC_2905 7799065 20.05 µM -0.800038697932038 0.195550656006448 no 2736 0.211844188292906 851 1296806
SGTC_3135 9127742 49.47 µM -0.80068248092515 0.195348463537628 no 2737 0.211657743603018 881 3643468
SGTC_1001 4048-4355 44.4 µM -0.800957587489152 0.195262099760859 no 2738 0.211578099847828 869 21824233
SGTC_3053 9095903 49.47 µM -0.801957255763332 0.194948470821583 no 2739 0.211288842158125 913 17174018
SGTC_55 0767-0285 6.563 µM -0.805260353290493 0.193914360139773 no 2740 0.210334727641906 879 3116166
SGTC_620 0109-0052 432 µM -0.806663763571719 0.193476004084286 no 2741 0.209930113253175 881 493037
SGTC_157 1348-1695 65.819 µM -0.807101122912334 0.193339518270177 no 2742 0.209804112614934 867 5380510
SGTC_474 dl-dihydrosphingosine 5 µM -0.808011964776289 0.193055462406397 no 2743 0.209541847215473 837 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2887 9044784 58.44 µM -0.808158839641421 0.193009681764603 no 2744 0.209499574518141 871 6465546
SGTC_2661 dactinomycin 12.96 µM -0.812802859230732 0.191565569532107 no 2745 0.208165547985499 869 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_377 3970-0964 33.1 µM -0.813047385890948 0.191489714986846 no 2746 0.208095445224404 862 16481235
SGTC_731 3966-0296 387 µM -0.81326820943051 0.19142122919559 no 2747 0.208032149829054 858 660956
SGTC_2869 9037858 32.47 µM -0.81375500111304 0.191270309572824 no 2748 0.207892659235055 868 27187042
SGTC_1942 st076330 65.2 µM -0.813783980490335 0.191261327421285 no 2749 0.207884356910654 879 24208414
SGTC_182 3448-4371 550.524 µM -0.81509448258258 0.190855407858489 no 2750 0.207509114805627 849 3491403
SGTC_2141 5621638 7.665 µM -0.815497555913776 0.190730664858257 no 2751 0.207393781508359 868 2856238
SGTC_2357 9067248 200 µM -0.816514099744306 0.190416287500775 no 2752 0.207103081322159 905 9150235
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.817182083166132 0.190209879644769 no 2753 0.206912189972936 897 279621
SGTC_2712 st079126 47.7 µM -0.817842798256914 0.190005852999954 no 2754 0.206723478191575 870 3152970
SGTC_1139 k015-0024 46.9 µM -0.817980553590201 0.189963331559441 no 2755 0.206684145702311 888 2766652
SGTC_3088 9117578 49.47 µM -0.820073728038835 0.18931794370991 no 2756 0.206087039049368 903 678341
SGTC_2120 5538279 151.968 µM -0.820515034375218 0.189182048341314 no 2757 0.205961281064762 873 2058197
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.824067264363269 0.188090367605948 no 2758 0.204950669657637 870 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2939 9044578 71.43 µM -0.826060715515219 0.187479441679759 no 2759 0.204384825453251 890 2653634
SGTC_3241 9133421 49.47 µM -0.827168400907949 0.187140503916068 no 2760 0.204070809584489 915 17018221
SGTC_1932 st074806 40.9 µM -0.82790819714053 0.186914346811574 no 2761 0.203861246161551 881 17251235
SGTC_3172 9105863 49.47 µM -0.828242173273391 0.186812305107439 no 2762 0.203766682172225 889 2348785
SGTC_3290 9121031 71.43 µM -0.828621353536436 0.186696493720567 no 2763 0.203659350520274 876 17014854
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.828823895769799 0.18663465033817 no 2764 0.203602032257409 878 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2822 7994718 71.43 µM -0.829192861324644 0.186522024570667 no 2765 0.203497641899755 916 1018011
SGTC_2789 5281112 71.43 µM -0.829862742988163 0.186317652557978 no 2766 0.203308195838115 883 765948
SGTC_185 k048-0037 25.491 µM -0.829894640292174 0.186307924575178 no 2767 0.203299177738395 862 6827589
SGTC_1981 st071826 47 µM -0.830268620354398 0.186193892279465 no 2768 0.203193462801714 862 11838600
SGTC_1883 5-benzylidenerhodanine 20 µM -0.830494071687882 0.186125169588733 no 2769 0.203129749128108 853 1273210
SGTC_1248 0469-0687 58.6 µM -0.830601415650978 0.186092454234559 no 2770 0.20309941737939 877 4017482
SGTC_481 bay k-8644 50 µM -0.832264067433278 0.185586181040862 no 2771 0.202629954000502 890 2303 A calcium channel antagonist.
SGTC_706 4262-0057 46.9 µM -0.834034769703265 0.185047947545508 no 2772 0.202130695519523 891 883298
SGTC_2611 pyromycin 23.93 µM -0.834719182555949 0.184840169345963 no 2773 0.20193791924579 885 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2733 amorolfine 100 µM -0.835042641777058 0.184742022114825 no 2774 0.201846849882747 919 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3115 9123671 49.47 µM -0.835432415802712 0.184623796032905 no 2775 0.201737142380914 899 3286988
SGTC_2634 4'-methoxyflavone 100 µM -0.835677367323812 0.18454952152648 no 2776 0.201668215531037 895 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2304 7443016 91.4 µM -0.836719406770604 0.184233760745968 no 2777 0.201375153979535 895 939854
SGTC_779 1360-0071 233 µM -0.836843522704934 0.184196173320038 no 2778 0.201340264827888 859 7566
SGTC_3098 9119039 49.47 µM -0.836890529820764 0.18418193887206 no 2779 0.20132705201215 873 17161528
SGTC_999 SEC7.066 22.7 µM -0.840314161185581 0.183147054157837 no 2780 0.200366131737941 892 740511 YDR170C SEC7
SGTC_2603 homopterocarpin 100 µM -0.840874163198739 0.182978124297729 no 2781 0.200209217002909 890 101795 A weak amylase inhibitor.
SGTC_3221 9128209 49.47 µM -0.842117452034239 0.182603422249093 no 2782 0.199861106737202 897 16460723
SGTC_1241 0364-0022 50.8 µM -0.843414695490361 0.182212970586648 no 2783 0.199498277975271 903 4563895
SGTC_2841 9004761 38.96 µM -0.844450821574789 0.181901486625154 no 2784 0.19920876667732 873 2991039
SGTC_2900 5328528 85.29 µM -0.844524628567295 0.181879311213714 no 2785 0.199188153404409 888 795359
SGTC_3356 9151811 4.48 µM -0.84580737152428 0.181494179431063 no 2786 0.198830106261212 897 1859254 YPR165W RHO1
SGTC_1112 tnp00069 1.16933 µM -0.846162369895468 0.181387684684119 no 2787 0.198731085507083 888 145826
SGTC_2961 9083290 32.55 µM -0.84660224149333 0.181255783391727 no 2788 0.198608432066532 888 17741490
SGTC_838 0109-0203 71.4 µM -0.847368799772645 0.181026064390568 no 2789 0.198394794716341 865 759422
SGTC_944 3370-0224 231 µM -0.847755971101945 0.180910107861323 no 2790 0.198286944026096 893 4580514
SGTC_101 0490-5701 117.494 µM -0.849057529392182 0.180520636852062 no 2791 0.19792464063764 864 4661669
SGTC_2488 5268135 45.7 µM -0.850847256679916 0.179985948391785 no 2792 0.197427103387454 896 1270356 YLR208W SEC13
SGTC_1288 0973-0013 65.5 µM -0.851730280967781 0.179722507968951 no 2793 0.197181904938062 886 4315430
SGTC_409 arachidonic acid 100 µM -0.851909978365784 0.179668926940894 no 2794 0.197132029083268 887 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_22 0964-0034 14.468 µM -0.851968039243427 0.179651616863134 no 2795 0.197115915646529 899 138402
SGTC_1426 4048-4480 71.7 µM -0.852240623495225 0.179570363506931 no 2796 0.19704027692683 881 14224343
SGTC_1425 4048-4433 7.33 µM -0.8525198209799 0.179487162791086 no 2797 0.1969628213317 929 23734946
SGTC_812 4251-0442 148 µM -0.852759697088175 0.179415699182894 no 2798 0.196896289083775 915 5723007
SGTC_3175 9106517 49.47 µM -0.85402865373136 0.179037950790377 no 2799 0.19654455658492 893 41468073
SGTC_2137 5261020 140 µM -0.855328374642278 0.178651563516964 no 2800 0.196184691713791 880 763655
SGTC_722 3534-0461 190 µM -0.855612135485067 0.178567275615938 no 2801 0.196106177586995 882 658262
SGTC_1745 st081495 74 µM -0.856240869011952 0.178380606782253 no 2802 0.195932280460897 865 13842402 YBL026W LSM2
SGTC_3163 9099914 49.47 µM -0.856957042269208 0.178168127233307 no 2803 0.195734312997126 911 16268368
SGTC_475 α-linolenic acid 10 µM -0.85735161463861 0.178051130789269 no 2804 0.195625295623235 867 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2848 9016370 25.97 µM -0.858195729474875 0.177801001166742 no 2805 0.195392196876391 852 7894410
SGTC_1747 st037496 66.6 µM -0.858619359628662 0.177675553895942 no 2806 0.195275276810438 904 723305
SGTC_2028 5153890 36.43 µM -0.860168590502709 0.177217264384579 no 2807 0.194848058001569 903 2830968 YPR165W RHO1
SGTC_1473 k844-0725 134 µM -0.860524804544441 0.177111995717204 no 2808 0.194749908186511 888 54682906
SGTC_140 0062-0056 502.533 µM -0.861606625823365 0.176792537214059 no 2809 0.194452011826617 899 3758964
SGTC_3220 9131269 49.47 µM -0.862206048627598 0.176615686423287 no 2810 0.194287070899037 905 17722206
SGTC_2389 9091542 195.52 µM -0.864368374243148 0.175978654469739 no 2811 0.193692780190591 875 3626624 YOL127W RPL25
SGTC_2057 5236571 38.335 µM -0.864692498114891 0.175883291494466 no 2812 0.193603794036014 897 54684039 YBR257W POP4
SGTC_268 camptothecin 39.6153 µM -0.865479610378218 0.175651845420377 no 2813 0.193387801164456 911 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1899 st063254 59.6 µM -0.866157196490362 0.175452759555469 no 2814 0.19320198137027 894 3093813
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.867353032146623 0.175101752635671 no 2815 0.192874303916537 894 66535 A nucleotide analog.
SGTC_181 1447-1644 8.07 µM -0.868283697226473 0.174828888202585 no 2816 0.192619522351332 919 534600
SGTC_3335 9143315 29.6265 µM -0.870668889402855 0.174130799669169 no 2817 0.191967484982912 873 4899691
SGTC_2878 9043973 25.97 µM -0.871989168309081 0.173745148565502 no 2818 0.191607143337339 906 6465167
SGTC_419 nsc-638432 893 µM -0.871993552708994 0.173743868795936 no 2819 0.191605947400593 891 368090
SGTC_2173 5763948 167 µM -0.87509166761949 0.172841054422855 no 2820 0.1907620152186 885 2867177
SGTC_1383 3049-0032 20.7 µM -0.875158997194922 0.172821467321067 no 2821 0.190743699879888 911 712864
SGTC_1570 verbenone 133 µM -0.875540485006133 0.172710513974094 no 2822 0.19063994597651 908 29025 A natural terpanoid with antifungal properties.
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.876473429072685 0.172439364382712 no 2823 0.190386357542853 887 6708514
SGTC_636 0kpi-0074 126 µM -0.87678250108908 0.17234959602087 no 2824 0.190302392757933 901 616434
SGTC_738 1315-0003 72.4 µM -0.878020578564372 0.171990301814363 no 2825 0.189966275610138 914 6251474
SGTC_2319 6033012 152.6 µM -0.878336139425766 0.171898801527386 no 2826 0.189880664555421 909 847246
SGTC_112 phenothiazine 287.218 µM -0.880219650655486 0.171353303675806 no 2827 0.189370165077881 903 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_365 0121-0052 13.6 µM -0.880596337190638 0.171244341581498 no 2828 0.189268170901493 862 3101739
SGTC_2140 5586273 200 µM -0.880961918613778 0.171138634174866 no 2829 0.189169215965374 897 854421
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.884369219243361 0.170155425124863 no 2830 0.188248466698391 910 4174840
SGTC_3130 9127414 49.47 µM -0.884922168874687 0.169996208282291 no 2831 0.188099305233411 903 1494646
SGTC_1049 3226-0134 66 µM -0.885602438860173 0.169800461754072 no 2832 0.187915898449993 892 5702385
SGTC_723 4182-0001 115 µM -0.888018913670674 0.169106294438962 no 2833 0.1872652887688 908 744821 YLR208W SEC13
SGTC_3285 9112818 20.8695 µM -0.891512325645426 0.168105987784563 no 2834 0.186327191058154 902 17017947 YPR165W RHO1
SGTC_571 k831-0106 44.2 µM -0.891612452788029 0.168077373531154 no 2835 0.186300346569805 884 4783639
SGTC_2294 7971431 200 µM -0.894258593359167 0.167322297718453 no 2836 0.185591774374569 926 5741572
SGTC_1314 1222-0010 41.1 µM -0.894629064500825 0.16721675856447 no 2837 0.185492704823895 914 3526027
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.897695620873596 0.166344811649648 no 2838 0.184673922368988 929 688801
SGTC_2596 sinensetin 100 µM -0.89769799500401 0.166344137727095 no 2839 0.184673289338747 918 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1557 sumaresinolic acid 42.3 µM -0.898364369217636 0.16615504991001 no 2840 0.184495662869811 893 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1214 0358-0031 63.7 µM -0.898369800329742 0.166153509368924 no 2841 0.184494215607547 934 4301366
SGTC_2155 5570423 76 µM -0.898400304360683 0.16614485703753 no 2842 0.184486087139672 918 797402
SGTC_1460 k062-0059 9.15 µM -0.900815713940585 0.165460661047324 no 2843 0.183843155576214 881 1373085
SGTC_2587 piperic acid 92.2 µM -0.901564021925631 0.165249063468582 no 2844 0.183644255113678 885 5370536
SGTC_2722 naftopidil 47.16 µM -0.903651185654362 0.164659806137398 no 2845 0.183090195356614 915 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2330 7979373 200 µM -0.904094386900171 0.164534855052084 no 2846 0.182972677251854 893 1863007
SGTC_2698 st077697 67.5 µM -0.904826912622177 0.164328469891554 no 2847 0.182778545825547 907 3154499
SGTC_2171 5739187 198.077 µM -0.905494366409494 0.164140564605623 no 2848 0.182601771534469 883 2262761
SGTC_741 4582-0002 126 µM -0.906595507217048 0.163830870082509 no 2849 0.182310369241325 894 2912688
SGTC_2970 9090938 41.86 µM -0.906596846188889 0.163830493729291 no 2850 0.182310015077188 896 17217104
SGTC_3222 9128301 49.47 µM -0.907043227888661 0.163705057697986 no 2851 0.182191969052208 889 4911358
SGTC_1204 4049-0315 18.3 µM -0.907051117849923 0.163702841130723 no 2852 0.182189882974924 913 588402
SGTC_2238 6671620 73.2395 µM -0.908551974371772 0.163281552175107 no 2853 0.181793333478984 886 729941
SGTC_2290 7904846 200 µM -0.908606424249022 0.163266281400872 no 2854 0.181778957136377 903 2962154
SGTC_1778 st046819 58.9 µM -0.908865188962696 0.163193722066033 no 2855 0.181710645488592 916 671715
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.910948511839518 0.162610308207106 no 2856 0.181161251609568 910 616764
SGTC_448 monastrol 171 µM -0.911538308608166 0.162445388239955 no 2857 0.181005905249407 918 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1910 st062352 60.4 µM -0.911907394449961 0.162342239227145 no 2858 0.180908734334492 916 2245730
SGTC_3316 9136639 10.545 µM -0.915981878545097 0.161206370541991 no 2859 0.179838199798767 892 4903665
SGTC_3188 9110789 49.47 µM -0.916908571891764 0.160948756069993 no 2860 0.179595275894139 921 849217
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.918114497590169 0.160613919485566 no 2861 0.179279462815756 907 6708760
SGTC_1651 st011928 86.1 µM -0.918436771021415 0.16052451434125 no 2862 0.179195123617143 923 720198
SGTC_1105 epirubicin 18.1 µM -0.919447553584014 0.160244313824012 no 2863 0.178930762976065 900 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_124 0136-0217 7.121 µM -0.920189596314189 0.160038814687439 no 2864 0.178736845015255 900 3976905
SGTC_1653 st012112 65 µM -0.920539008303869 0.159942109259057 no 2865 0.178645579048645 902 720429
SGTC_3033 9090887 49.47 µM -0.92064756093412 0.159912073342783 no 2866 0.17861723121548 915 19325384
SGTC_1469 k284-2957 126 µM -0.92177668817688 0.159599868819597 no 2867 0.178322534769085 880 23884841
SGTC_3057 9095946 49.47 µM -0.923355304640739 0.159164049374776 no 2868 0.177911037851628 924 24540043
SGTC_251 melphalan 456.522 µM -0.924831443259455 0.158757227629955 no 2869 0.177526796034107 915 460612 A DNA alkylator.
SGTC_2069 5228469 200 µM -0.926996709873343 0.1581617175446 no 2870 0.176964121268364 925 2835210
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.927168539440595 0.158114522381524 no 2871 0.176919517271641 922 115019
SGTC_59 0330-0160 1.33 µM -0.928274064835642 0.157811096931932 no 2872 0.176632711846671 918 4293482
SGTC_696 1560-0013 611 µM -0.929721837098666 0.157414316205848 no 2873 0.176257562523422 901 1650269
SGTC_455 paf C-16 10 µM -0.932815022062622 0.156568787731679 no 2874 0.175457741852147 910 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2339 9000433 200 µM -0.935161475984908 0.155929377826333 no 2875 0.174852544315794 917 2988954
SGTC_2043 5101342 149 µM -0.935644446810929 0.155797981939626 no 2876 0.174728141058288 924 678451
SGTC_1641 st009299 47.1 µM -0.935679248476978 0.155788516702306 no 2877 0.174719179042475 893 4046054
SGTC_1404 3909-7820 48.3 µM -0.936440018583681 0.155581699808194 no 2878 0.174523340831611 882 23741373
SGTC_2526 patulin 37.61 µM -0.936650031499597 0.155524639284626 no 2879 0.174469303658115 915 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2419 paclitaxel 166.5 µM -0.937451469256188 0.155307015475074 no 2880 0.174263188152294 917 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3041 9091929 49.47 µM -0.937777870588311 0.155218441508128 no 2881 0.174179287907095 907 25236887
SGTC_2720 fluspirilene 36.88 µM -0.938415810919653 0.155045422985816 no 2882 0.174015381860365 930 3396 An atypical antipsychotic.
SGTC_2785 7756463 72.73 µM -0.938570068428673 0.155003605275061 no 2883 0.173975763196767 921 2201551
SGTC_87 0100-0052 35.5 µM -0.938670689586186 0.154976331871775 no 2884 0.173949923294217 935 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2353 9059630 146.67 µM -0.939450731305192 0.154765008785065 no 2885 0.173749688357846 927 4779114
SGTC_1841 st054148 70 µM -0.940086487903819 0.154592915226383 no 2886 0.173586599575653 944 675442
SGTC_2162 5663267 200 µM -0.942258275420966 0.154005986281317 no 2887 0.173030212313523 929 6456493
SGTC_1865 st057639 52.2 µM -0.943113023053073 0.153775394259583 no 2888 0.172811547591947 923 688818
SGTC_2047 4141938 200 µM -0.944288656145571 0.153458607969887 no 2889 0.17251108059922 926 3807862
SGTC_1471 k673-0312 37 µM -0.944698054513835 0.153348392960752 no 2890 0.172406525279729 902 24099884
SGTC_2432 5630864 12.22 µM -0.946436886021486 0.152880862914707 no 2891 0.171962899595941 933 5714970
SGTC_2455 5377712 9.75 µM -0.946447632171635 0.15287797647474 no 2892 0.171960160213368 875 2243908
SGTC_2404 5161160 200 µM -0.94653604312679 0.152854230466074 no 2893 0.171937623764314 907 2831543
SGTC_1917 st066507 28.5 µM -0.949352080664605 0.15209915982846 no 2894 0.171220786742955 911 3156428
SGTC_1995 st072814 61.1 µM -0.950949842310902 0.151671851571607 no 2895 0.170814919146489 920 5769371
SGTC_878 0828-0289 13.7 µM -0.953119081538022 0.151092984508615 no 2896 0.170264869556061 909 745350 YLR208W SEC13
SGTC_3102 9121669 49.47 µM -0.953458207953755 0.151002620799691 no 2897 0.170178980639633 938 41905072
SGTC_2068 5226020 147 µM -0.954603659064077 0.150697669558573 no 2898 0.169889083035321 944 1810509
SGTC_2824 7998404 51.95 µM -0.955483971888877 0.15046358445047 no 2899 0.169666503511931 929 837851
SGTC_2144 5628481 200 µM -0.956533600709199 0.150184793073091 no 2900 0.169401358487232 890 2818399
SGTC_728 3030-5151 22.5 µM -0.95729439626497 0.149982933916218 no 2901 0.169209341482541 924 3125388
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.958338708456897 0.149706145037163 no 2902 0.168945995432425 903 6312947
SGTC_42 0133-0086 60.653 µM -0.958973995533115 0.149537932704621 no 2903 0.168785922834383 934 162923 Model of phenazepam hydroxylation.
SGTC_1006 4099-6547 255 µM -0.959945115691393 0.149281041818971 no 2904 0.168541419156365 934 3146833
SGTC_2242 6630449 61.2675 µM -0.960917247611045 0.149024178583297 no 2905 0.168296888923895 936 691249 YDR170C SEC7
SGTC_2117 5521686 200 µM -0.96328931818576 0.148398653964114 no 2906 0.167701176167336 938 803312
SGTC_347 4534-1311 26.2 µM -0.968860328250257 0.14693647019604 no 2907 0.166307440773884 928 2862016
SGTC_176 1486-1328 72.834 µM -0.97046372727177 0.146517434156974 no 2908 0.165907698397847 912 22310231
SGTC_2234 tolnaftate 200 µM -0.970939455431198 0.146393260702232 no 2909 0.165789214475617 941 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2307 7538926 6.34 µM -0.973840804276658 0.145637487107361 no 2910 0.165067794691766 926 96582
SGTC_401 neomycin 50 µM -0.975305647109308 0.14525690791713 no 2911 0.164704335069486 894 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1571 st070080 73.4 µM -0.977243481053351 0.144754470418457 no 2912 0.164224313253993 912 4315245
SGTC_1501 4491-0275 38.4 µM -0.978189308320534 0.144509663866595 no 2913 0.163990351712213 913 5104718
SGTC_2734 clemastine 41.6 µM -0.978891020409551 0.144328221501833 no 2914 0.163816914745422 967 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_318 1488-0629 67.2 µM -0.980688968931454 0.143864025231149 no 2915 0.163373072663222 938 3662576
SGTC_2507 purpurin 79.67 µM -0.983113485276404 0.143239657438297 no 2916 0.162775793994529 930 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2086 5274770 176.623 µM -0.984830344372947 0.142798635839095 no 2917 0.162353706387498 910 689278
SGTC_578 3460-0051 92 µM -0.986428584437833 0.142388910497107 no 2918 0.161961421987636 951 2876744
SGTC_2136 5328288 199.296 µM -0.986803076036193 0.142293020827435 no 2919 0.161869593236956 940 262395
SGTC_2218 6965428 192.983 µM -0.988550457046924 0.141846176446445 no 2920 0.161441568005115 915 675684
SGTC_1892 st058411 7.36 µM -0.989002508884695 0.141730731566054 no 2921 0.161330957080672 933 3934738
SGTC_2197 6588183 93.1375 µM -0.989178939289174 0.141685692085869 no 2922 0.16128780037858 903 884136
SGTC_2937 9044753 11.33 µM -0.990290283667901 0.1414022089238 no 2923 0.161016127177151 894 6465530 YGL099W LSG1
SGTC_2805 7950783 58.44 µM -0.990563166048763 0.141332660555574 no 2924 0.160949465530081 919 1178958 YDL195W SEC31
SGTC_2440 5628896 157.78 µM -0.992357150422042 0.140876012732678 no 2925 0.160511666848393 942 5522048
SGTC_1128 3448-9350 235 µM -0.992501977085499 0.140839191699038 no 2926 0.160476357743835 908 619386
SGTC_1042 0350-0096 82 µM -0.99361479233624 0.140556485064416 no 2927 0.160205219901814 928 3122515
SGTC_2705 st078069 42.8 µM -0.994320187594133 0.140377481597725 no 2928 0.160033505253756 939 1530061
SGTC_369 0957-0393 4.5 µM -0.995898925200304 0.139977416969931 no 2929 0.159649628796705 941 6997992
SGTC_1005 4092-0690 4.4 µM -0.996575741496049 0.139806143860504 no 2930 0.159485242859292 942 1529343
SGTC_563 tetrahydrosecaminediol 614 µM -0.998549362797914 0.139307518776871 no 2931 0.159006520261511 934 334274 A psychoactive constituent of the cannabis plant.
SGTC_1621 st003705 32.4 µM -0.999705671139846 0.139015946328649 no 2932 0.158726483379894 928 24207032
SGTC_2133 5320837 200 µM -1.004267031276 0.137869816376146 no 2933 0.157624960123125 950 2841355
SGTC_983 1491-0821 12.2 µM -1.00635575360282 0.13734714238297 no 2934 0.157122234871223 924 46495113
SGTC_486 niguldipine 82 µM -1.01243316748938 0.135834056780203 no 2935 0.1556654932647 919 1236 A calcium channel blocker.
SGTC_2135 5326629 150.42 µM -1.01305821493567 0.135679089439215 no 2936 0.155516177676063 938 5020077
SGTC_282 k297-0036 65.7 µM -1.01325257779004 0.135630925959816 no 2937 0.155469766219673 950 5061378
SGTC_1735 st034310 56.75 µM -1.02073802300276 0.133784926586541 no 2938 0.153689287408686 912 871153
SGTC_2189 6047310 154.431 µM -1.02107428902036 0.133702406724504 no 2939 0.153609621691657 930 711535
SGTC_3022 9087993 49.47 µM -1.02228362205263 0.133405925005869 no 2940 0.153323341277659 938 17173644
SGTC_2343 7990716 14.84 µM -1.02338973896046 0.133135144160664 no 2941 0.15306180450087 949 6456862
SGTC_2051 5263410 176 µM -1.02379511947591 0.133036000537646 no 2942 0.152966028043519 928 227584
SGTC_929 2805-0021 398 µM -1.02462974560125 0.132832036686361 no 2943 0.152768961829266 981 3098024
SGTC_3189 9110682 49.47 µM -1.0254756158066 0.132625544843614 no 2944 0.152569412614699 967 17122418
SGTC_53 0973-0023 39.979 µM -1.02565642392312 0.1325814350925 no 2945 0.152526780621923 937 674768
SGTC_1864 st057645 30.4 µM -1.02670268419454 0.132326389036272 no 2946 0.152280242491275 933 688666
SGTC_2821 7996764 71.43 µM -1.02738669149968 0.132159832028472 no 2947 0.152119207823428 901 2987135
SGTC_2996 9066192 71.4286 µM -1.0290256283302 0.131761336231865 no 2948 0.151733815993785 921 6472854
SGTC_931 2812-0076 566 µM -1.02972897336603 0.131590577394297 no 2949 0.151568625348882 947 3450959
SGTC_606 k015-0008 38.6 µM -1.02982140969421 0.131568146967441 no 2950 0.151546924246556 965 1970475
SGTC_2755 lomerizine 42.69 µM -1.02997991825323 0.131529689719204 no 2951 0.151509716299461 920 3949 A calcium channel blocker.
SGTC_2002 4023503 131 µM -1.03030824293436 0.131450056471885 no 2952 0.151432665413983 959 4736863 YCR052W RSC6
SGTC_3268 9137683 49.47 µM -1.03106279509388 0.131267170386263 no 2953 0.151255686683999 991 1953228
SGTC_3191 9110352 49.47 µM -1.03145270381177 0.131172734376091 no 2954 0.151164288295286 920 17122424
SGTC_1523 st012844 44.7 µM -1.03260021537093 0.13089507904611 no 2955 0.150895513676794 950 4274103
SGTC_2194 5927483 104.545 µM -1.03348887460288 0.13068033564488 no 2956 0.150687587146214 920 760979
SGTC_1829 berberine 14.4 µM -1.03500054164446 0.130315602971684 no 2957 0.150334329121832 903 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_661 1304-0007 33.6 µM -1.0387097470707 0.129423637637609 no 2958 0.149469873321417 938 3117130
SGTC_868 0527-0199 213 µM -1.0395663760633 0.129218243878923 no 2959 0.149270702585865 939 2849450
SGTC_1696 st025591 34.7925 µM -1.04021547937879 0.129062759058147 no 2960 0.149119900725323 918 2787147
SGTC_2836 9010338 19.48 µM -1.04045789224928 0.129004725280835 no 2961 0.149063608659078 942 2994051
SGTC_705 1124-0212 310 µM -1.04331902318124 0.128321135987614 no 2962 0.148400281730753 924 9554485
SGTC_1037 k284-1091 78.7 µM -1.04662616647925 0.127534122838447 no 2963 0.147636014359358 933 3334711
SGTC_1817 st052116 64.4 µM -1.04678170286009 0.127497192083607 no 2964 0.14760013556021 951 4361398
SGTC_1879 gemcitabine 100 µM -1.05206623939145 0.12624684174035 no 2965 0.146384580065698 949 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1839 st053978 48 µM -1.05257868094904 0.126126051367388 no 2966 0.146267066138203 963 3788398
SGTC_1963 st076565 50.3 µM -1.05338717611926 0.125935640462419 no 2967 0.14608178957387 969 4914280
SGTC_3212 9128307 49.47 µM -1.05362836965554 0.12587887515504 no 2968 0.146026547668549 953 27243542
SGTC_1419 3993-2473 62.6 µM -1.05692237352848 0.125105411445731 no 2969 0.145273508269125 944 704026
SGTC_387 norethindrone acetate 66.7 µM -1.05727956583807 0.125021739171037 no 2970 0.145192008143924 962 541197
SGTC_1479 0549-0158 134 µM -1.05836140258622 0.124768557492724 no 2971 0.144945354536688 950 5440202
SGTC_749 1000-0129 128 µM -1.05952908452794 0.124495687822578 no 2972 0.144679445369055 956 708470
SGTC_3296 9122258 64.045 µM -1.05982688124482 0.124426164041999 no 2973 0.144611682536709 950 4730474
SGTC_880 0833-0487 87.2 µM -1.06033527987646 0.124307535771461 no 2974 0.144496047225803 940 76075
SGTC_2512 diallyl trisulfide 49.23 µM -1.06078342032407 0.124203033585716 no 2975 0.144394169321189 977 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2956 9076196 2.52 µM -1.06170031320188 0.123989414228305 no 2976 0.144185878565253 960 16423868
SGTC_1838 st055369 84.5 µM -1.06247233936341 0.123809745673741 no 2977 0.144010654377806 937 676036
SGTC_1127 asiatic acid 681.4 nM -1.06475218684405 0.123280235883834 no 2978 0.143494043572122 963 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1468 k284-1086 134 µM -1.06565198066746 0.123071690113748 no 2979 0.143290496073991 940 15996457
SGTC_412 gemfibrozil 100 µM -1.06591797430947 0.123010087986924 no 2980 0.143230361493155 931 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1015 4130-4525 82 µM -1.0675710457604 0.122627733671462 no 2981 0.142857025097011 944 1363237
SGTC_2293 7624732 200 µM -1.07166437270311 0.121684540565349 no 2982 0.141935404261892 928 894453
SGTC_1847 st056231 15 µM -1.07281837912126 0.121419555590486 no 2983 0.141676306435178 931 5393180
SGTC_1092 toremifene 6.32 µM -1.07349637842391 0.121264061529298 no 2984 0.141524231354717 970 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_303 1348-1668 34.2 µM -1.07365374602848 0.121227990480979 no 2985 0.141488949660265 950 5380509
SGTC_814 3342-0569 96 µM -1.07425157640773 0.121091027454562 no 2986 0.141354970887288 929 4346283
SGTC_1819 st053448 58.6 µM -1.07552282276594 0.120800146664682 no 2987 0.141070359893458 962 2857616
SGTC_74 000s-0487 160.283 µM -1.07593116797666 0.120706815421858 no 2988 0.140979020688366 946 677548
SGTC_2593 nobiletin 86.24 µM -1.07690205118673 0.120485114539014 no 2989 0.140762013322424 926 72344 An anti-infammatory.
SGTC_2119 5528445 120.635 µM -1.07772283420997 0.120297912801352 no 2990 0.140578732557306 961 791935
SGTC_755 1995-0008 37.3 µM -1.07948387893694 0.119896950674947 no 2991 0.140186038277837 931 689533
SGTC_3331 9141060 1.957 µM -1.08032102123793 0.119706677319146 no 2992 0.139999625977323 933 4906567 YPR165W RHO1
SGTC_1822 st052468 42 µM -1.08074358388061 0.119610714333523 no 2993 0.139905595012399 945 2873678
SGTC_732 3970-1727 52.7 µM -1.08596710853816 0.118428943630476 no 2994 0.138746772218556 963 1275699
SGTC_3171 9103192 49.47 µM -1.08746082365019 0.118092527984697 no 2995 0.138416601608509 972 13018434
SGTC_799 1310-0557 151 µM -1.08804447935846 0.117961260425347 no 2996 0.138287736031506 963 5354492
SGTC_1433 4060-0023 7.6 µM -1.08821455446446 0.117923028975141 no 2997 0.138250200474006 944 3840627
SGTC_927 2425-1185 123 µM -1.08983766356443 0.117558608727594 no 2998 0.137892329919801 964 730375
SGTC_2072 5231554 129 µM -1.08996584855855 0.117529862654673 no 2999 0.1378640940532 946 789545
SGTC_1957 st077035 62.4 µM -1.09052922353279 0.117403582232172 no 3000 0.137740043761743 961 705593
SGTC_1467 k284-1082 293 µM -1.09138092445168 0.11721285606319 no 3001 0.137552651248777 949 3334705
SGTC_3350 9150499 3.57 µM -1.09148947300189 0.117188563954978 no 3002 0.137528780743436 969 4910996 YPR165W RHO1
SGTC_2058 5236698 133 µM -1.09523949931404 0.116351533552071 no 3003 0.136705862573257 930 766665
SGTC_420 mitomycin C 81.9 mM -1.09615777529503 0.116147216430475 no 3004 0.136504867237969 931 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1965 Pectolinarigenin 58.4 µM -1.09772131720455 0.115799913293717 no 3005 0.13616309918991 960 5320438 An anti-inflammatory.
SGTC_1951 sophoraflavanone G 9.2 µM -1.09773442991289 0.1157970037436 no 3006 0.136160235416622 936 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_3228 9131799 49.47 µM -1.09783453705492 0.115774792900332 no 3007 0.136138373697686 968 17015818
SGTC_1063 disulfiram 1.84 µM -1.09906056921855 0.115503017680486 no 3008 0.135870823737219 959 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1185 1319-0113 81.3 µM -1.09941594547695 0.115424326039779 no 3009 0.135793339369768 958 4672763
SGTC_2911 7942208 15.64 µM -1.0994360774818 0.115419869312221 no 3010 0.135788950799392 919 1243384
SGTC_680 0417-1641 114 µM -1.09964808087892 0.11537294443212 no 3011 0.135742742132576 957 2835990
SGTC_3023 9089636 49.47 µM -1.09975795047719 0.115348631205076 no 3012 0.135718798981919 975 17249241
SGTC_2195 6536160 144.242 µM -1.10036732626652 0.115213847527515 no 3013 0.13558605428613 950 3834386
SGTC_1408 3909-7976 48.8 µM -1.10168904569698 0.114921890291291 no 3014 0.135298440455111 947 24152374
SGTC_326 k292-0812 17.5 µM -1.10323166532167 0.114581803936431 no 3015 0.134963286707155 930 3579357
SGTC_733 4069-0007 56.1 µM -1.10811191425434 0.113510622061419 no 3016 0.133906743066969 977 5717425 YNL287W SEC21
SGTC_1842 st055362 61.2 µM -1.10906571508546 0.11330210606958 no 3017 0.133700916939141 941 676032
SGTC_1816 st051957 91.6 µM -1.1099493496536 0.113109173487682 no 3018 0.133510426580053 983 674121
SGTC_3158 9100007 49.47 µM -1.1099696251287 0.113104749297752 no 3019 0.13350605786701 971 19297233
SGTC_955 1216-0110 33 µM -1.11045233136499 0.112999457325119 no 3020 0.133402079223922 953 3619719
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.11208664939064 0.112643485482504 no 3021 0.133050448185545 975 803109
SGTC_2675 theaflavin digallate 100 µM -1.11365713463268 0.112302172329169 no 3022 0.132713152655693 976 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1385 3091-4834 14.1 µM -1.11388577797567 0.112252543024616 no 3023 0.132664095729926 943 4072814
SGTC_2942 9052777 62.25 µM -1.11676323885059 0.111629301128955 no 3024 0.132047785340833 972 6469503
SGTC_2904 7225135 42.03 µM -1.11679058989232 0.111623388948398 no 3025 0.132041936633047 980 4446116
SGTC_1337 1486-1011 40.3 µM -1.11891550400362 0.111164753702487 no 3026 0.131588094025375 938 X1337
SGTC_72 0744-0168 198.391 µM -1.12051970952509 0.110819401648733 no 3027 0.131246179204126 979 677577
SGTC_2950 9072895 21.46 µM -1.12079646694106 0.110759899370411 no 3028 0.131187254197569 930 17332245
SGTC_1821 st053465 65.6 µM -1.1220505075936 0.110490570074927 no 3029 0.13092048274639 966 675086
SGTC_149 3970-0822 46.1 µM -1.12324002860597 0.110235531804234 no 3030 0.130667783185274 957 3114250 YBL034C STU1
SGTC_675 1309-0189 238 µM -1.13065627284941 0.108654977155311 no 3031 0.129099896298573 948 4246530
SGTC_3051 9093778 49.47 µM -1.13196453056376 0.108377860159919 no 3032 0.128824673370673 991 17217378
SGTC_610 4215-0184 155 µM -1.13364322834436 0.108023021480267 no 3033 0.128472116188991 913 5605015
SGTC_805 3852-0218 479 µM -1.13408935925688 0.107928860364899 no 3034 0.128378533303651 960 6615355
SGTC_764 1951-2361 146 µM -1.13593330891095 0.107540300397262 no 3035 0.127992238335218 944 5438930
SGTC_300 r073-0011 5.04 µM -1.13693133194237 0.107330416360174 no 3036 0.127783496422177 962 2735780
SGTC_337 1315-0038 354 µM -1.13803352401146 0.10709896891913 no 3037 0.127553242062247 956 1626437
SGTC_2971 9092186 9.93 µM -1.1390160981901 0.106892943492846 no 3038 0.127348219927692 953 25236400
SGTC_1307 1187-1599 12.2 µM -1.14203068762342 0.106262631341463 no 3039 0.126720632052713 961 1538471
SGTC_259 usnic acid 108.925 µM -1.14243571810017 0.106178149633775 no 3040 0.126636475781715 992 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_349 k015-0014 24 µM -1.14244620316014 0.10617596329273 no 3041 0.126634297737822 956 2196908
SGTC_144 4161-2749 112.381 µM -1.1472053720513 0.105186937794909 no 3042 0.125648375931779 952 797501 YMR168C CEP3
SGTC_1197 1601-0112 267 µM -1.14761634336883 0.105101845633398 no 3043 0.125563489942303 962 7350313
SGTC_197 4544-0043 41.561 µM -1.15573439910145 0.103431191564187 no 3044 0.123894906603502 975 896523
SGTC_1943 st076331 65.2 µM -1.17005785716363 0.100530659988583 no 3045 0.120988843170178 971 24208415
SGTC_551 k048-0028 34.9 µM -1.17027291473948 0.100487567216237 no 3046 0.120945579046495 974 6836383
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.17549187981908 0.0994459309255899 no 3047 0.119898991981483 987 61125 An anti-inflammatory.
SGTC_872 0588-0139 234 µM -1.17652086271328 0.0992414943616503 no 3048 0.119693400293833 959 2047100
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.17782887919022 0.0989820637065695 no 3049 0.119432416507287 1007 4620898
SGTC_2656 pseudo-anisatin 100 µM -1.18663266705059 0.0972488266399613 no 3050 0.117686272350331 1015 6708809 A neurotoxin.
SGTC_3263 9137018 49.47 µM -1.18681374344891 0.0972134126329831 no 3051 0.117650548286565 956 43844957
SGTC_2170 morpholine 200 µM -1.18788616178643 0.0970038684461914 no 3052 0.117439131170138 974 121171 Reacts with secondary amines.
SGTC_2473 5854593 8.94 µM -1.18930817380493 0.0967265272848452 no 3053 0.117159210021898 965 2872951
SGTC_1998 st075797 76.8 µM -1.18937377323882 0.096713747209737 no 3054 0.117146308277106 945 24208315
SGTC_1721 st082152 9.2685 µM -1.19363507573217 0.0958862153689453 no 3055 0.116310373552275 969 5296051
SGTC_1614 st002383 48.6 µM -1.19427741304497 0.0957619284778864 no 3056 0.116184734982332 955 1947235
SGTC_1170 0310-0127 64.8 µM -1.19547509122967 0.0955305043525867 no 3057 0.115950731270244 981 774975
SGTC_1321 1326-2144 215 µM -1.19640833289793 0.0953504620962047 no 3058 0.115768625552863 988 3513030
SGTC_3182 9108849 49.47 µM -1.19686894402005 0.0952616924966215 no 3059 0.11567882028918 962 17133045
SGTC_3192 9110362 49.47 µM -1.19958702689815 0.094739098611117 no 3060 0.115149883710858 1006 16649480
SGTC_2984 9022109 38.96 µM -1.20271910013075 0.0941395321940815 no 3061 0.114542520036506 1004 6459207
SGTC_521 r062-0005 13.8 µM -1.20394188572462 0.0939062181672624 no 3062 0.114306020519472 973 2832033
SGTC_3274 9138298 49.47 µM -1.20406245740547 0.0938832355816499 no 3063 0.114282719542488 989 17015756
SGTC_1660 st012960 28.1 µM -1.20465134439499 0.0937710454451886 no 3064 0.114168963292895 972 24207266
SGTC_2600 tangeritin 87.95 µM -1.20623339605181 0.0934701354981192 no 3065 0.113863755247314 964 68077 A bioactive flavone.
SGTC_2655 perillic acid 100 µM -1.20657184995489 0.0934058534818324 no 3066 0.113798536580572 989 5702197 An apoptosis inducer.
SGTC_413 propylparaben 100 µM -1.20717580749332 0.0932912259187585 no 3067 0.113682222613286 959 7175 A pharmaceutical preservative.
SGTC_328 k915-0120 63.5 µM -1.20955035837718 0.0928415577646008 no 3068 0.113225738224488 969 6624543
SGTC_2635 hydroquinidine 100 µM -1.21076733579605 0.0926117211186242 no 3069 0.112992293618402 966 442912 An experimental heart treatment.
SGTC_115 0527-0192 112.043 µM -1.21173875269938 0.0924285629559152 no 3070 0.112806199930123 989 4233931
SGTC_2756 carbadox 75.1 µM -1.21208204276228 0.0923639006340015 no 3071 0.11274048843873 947 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2232 chlorophetanol 41.5365 µM -1.2141870075071 0.0919681400328432 no 3072 0.112338160363421 989 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1313 1220-0047 237 µM -1.21461030343018 0.0918887068023503 no 3073 0.112257378624273 981 3528706
SGTC_2416 tofa 880 nM -1.21803158703862 0.0912485530313372 no 3074 0.111605984766544 975 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_308 4092-1169 104 µM -1.22018730030947 0.0908469008630516 no 3075 0.111196940011724 981 2268590 YDL196W YDL196W
SGTC_1676 st018489 23.4 µM -1.22291900447257 0.0903398164341327 no 3076 0.110680144898408 970 3696235
SGTC_2684 capsaicin 100 µM -1.22560960897582 0.0898424190470821 no 3077 0.110172810047692 975 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1380 2291-0730 164 µM -1.22761290916889 0.0894734039298203 no 3078 0.109796156739703 984 2999191
SGTC_504 lovastatin 124 µM -1.22898436245034 0.0892214281046232 no 3079 0.109538834543026 986 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1767 st044992 70.3 µM -1.23368048166777 0.0883626138519623 no 3080 0.108660994913629 977 9600693
SGTC_2694 st077685 81.9 µM -1.23372808164273 0.0883539405386229 no 3081 0.108652123088188 975 2838096
SGTC_1154 4088-0362 150 µM -1.2351696245874 0.0880915737525204 no 3082 0.108383690762865 982 6618304
SGTC_1025 k007-0731 70 µM -1.2366262120161 0.0878270592254861 no 3083 0.108112942009265 983 6256118
SGTC_2489 cantharidin 73.42 µM -1.23720959415735 0.0877212840437671 no 3084 0.108004640296349 961 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_256 clotrimazole 625 nM -1.24253323725241 0.0867604216867297 no 3085 0.107019942608874 952 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3148 9097893 49.47 µM -1.24338648342083 0.0866071537042586 no 3086 0.106862724357943 947 17174100
SGTC_870 0573-2213 57.6 µM -1.24867813549125 0.085661134953955 no 3087 0.105891410517054 982 3916321
SGTC_654 1124-0271 80.9 µM -1.25173474955277 0.0851182234179495 no 3088 0.105333266693224 987 5403748
SGTC_1578 josamycin 24.2 µM -1.25367712631712 0.0847745636217012 no 3089 0.104979692582689 987 5282165 A P450 substrate.
SGTC_2769 toremifene 3.73 µM -1.25425155834874 0.0846731304298979 no 3090 0.104875292551908 987 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1165 k072-0275 30.3 µM -1.25519325189247 0.0845070431684044 no 3091 0.104704307313518 984 6153523 YGL055W OLE1
SGTC_304 1310-0298 97 µM -1.25623526375449 0.0843235476568877 no 3092 0.10451534247647 992 1550234
SGTC_322 k048-0136 19.3 µM -1.25649334916919 0.0842781457365747 no 3093 0.104468577880137 997 6823282
SGTC_510 ag-490 170 µM -1.25969556591841 0.0837163426437136 no 3094 0.103889602782818 1003 5328779
SGTC_2801 7907800 81.82 µM -1.26766583573961 0.0823302444889198 no 3095 0.102458655104779 972 6620925
SGTC_905 2-aminofluorene 215 µM -1.26825361093003 0.0822287136884874 no 3096 0.102353698697925 989 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2087 5276107 200 µM -1.26993700321741 0.0819384505836646 no 3097 0.102053535492483 986 144405
SGTC_541 4513-1321 94 µM -1.27145345385535 0.0816776344549036 no 3098 0.101783688225693 965 747515
SGTC_3339 9145883 14.936 µM -1.27286472159147 0.0814354715809834 no 3099 0.101533024869398 948 2030670
SGTC_2260 7964312 200 µM -1.27956129128511 0.0802937671201763 no 3100 0.100349735416686 1002 231951
SGTC_2649 anisomycin 9.56 µM -1.27989426274525 0.0802373157973449 no 3101 0.100291162837264 997 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2802 7925815 54.55 µM -1.28001367687896 0.080217077870698 no 3102 0.100270162931474 980 1262923
SGTC_1812 st052057 4.327 µM -1.28092468593193 0.0800628099310853 no 3103 0.100110060523352 995 3645418
SGTC_849 0386-0493 241 µM -1.28768224196667 0.0789254975136462 no 3104 0.0989282988128835 1000 726119
SGTC_343 4130-2827 29.8 µM -1.2914037065832 0.0783044143635333 no 3105 0.0982818630111692 1001 1118244
SGTC_978 1416-0512 87.4 µM -1.2914633225427 0.0782944951784695 no 3106 0.0982715326781484 1008 6814003
SGTC_531 3788-1495 174 µM -1.29658481908794 0.077445908717249 no 3107 0.0973870393014832 963 2896655
SGTC_2303 7774051 200 µM -1.29924066216396 0.0770086184518116 no 3108 0.0969306754766459 995 2953184
SGTC_932 2857-0803 154 µM -1.30431032585327 0.0761791011786946 no 3109 0.0960638980274461 992 674898
SGTC_244 nsc-207895 1.295 µM -1.30434856923506 0.0761728696025137 no 3110 0.0960573811565738 960 42640
SGTC_1474 0330-0125 5.35 µM -1.30575376932954 0.0759441679140645 no 3111 0.0958181531175868 1024 X1474
SGTC_595 3909-8003 73.7 µM -1.3083103221439 0.0755294206574685 no 3112 0.0953840377387736 1010 699517
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.31415973191646 0.0745869707653366 no 3113 0.0943962282185987 1029 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3206 9114350 49.47 µM -1.3169332213469 0.0741432583873686 no 3114 0.093930504787022 984 17087243
SGTC_1102 cgs 12066b 26.1 µM -1.31834917371324 0.0739175082942965 no 3115 0.0936933934043817 992 6438352 A 5-HT1B full agonist.
SGTC_421 streptovitacin 30 mM -1.318807694202 0.0738445175103782 no 3116 0.0936167056601518 1006 91467 include heat shock
SGTC_757 1066-0008 322 µM -1.32189054662964 0.0733551950337457 no 3117 0.0931023003882467 969 6842497
SGTC_407 eburnamonine 100 µM -1.33135391488185 0.0718686190896148 no 3118 0.091536292863593 980 3195
SGTC_971 1315-0384 26.7 µM -1.33952137382454 0.0706042839356357 no 3119 0.0902005005210639 1019 6769120
SGTC_2701 st077767 14.721 µM -1.34873362184382 0.069198806775321 no 3120 0.0887112710404141 1000 5721188
SGTC_1615 st002656 86.5 µM -1.34961619110496 0.0690652962103558 no 3121 0.0885695639338109 1012 1584458
SGTC_1573 oleylamine 1.06 µM -1.35494081544549 0.0682640220307601 no 3122 0.0877182071337676 987 5356789 An amine of the fatty acid oleic acid.
SGTC_1254 0550-0035 264 µM -1.35617275229642 0.0680796604294336 no 3123 0.0875221046678292 1006 15121435
SGTC_543 3844-1095 191 µM -1.3573199433779 0.067908327038127 no 3124 0.0873397865826488 996 4230703
SGTC_1758 st042942 75.2445 µM -1.3591666654199 0.0676332181408318 no 3125 0.0870468908667767 998 669317
SGTC_7 0192-1582 4.227 µM -1.36058903054702 0.0674219139463478 no 3126 0.0868218000377743 1025 252616
SGTC_1442 4112-3290 3 µM -1.36244433249624 0.0671470606497747 no 3127 0.0865288504643461 1021 704353
SGTC_1137 ixabepilone 100 µM -1.36286238017497 0.0670852488416336 no 3128 0.0864629434497924 998 154225 A novel microtubule stabilizer.
SGTC_970 1315-0089 19.5 µM -1.36313446145598 0.0670450430185116 no 3129 0.0864200688328679 989 6811083 YLR033W RSC58
SGTC_397 arbidol 50 µM -1.3753687651214 0.0652563522570232 no 3130 0.0845085737256293 1001 131410 A RNA synthesis inhibitor.
SGTC_691 1548-0686 185 µM -1.37601235980024 0.0651632919350585 no 3131 0.084408903362962 989 46495133
SGTC_2666 tannic acid 100 µM -1.37693876107137 0.0650295201431486 no 3132 0.0842655910158946 990 16134267 A thiamine antagonist.
SGTC_325 2810-4341 181 µM -1.38044450259043 0.0645252219010768 no 3133 0.0837249129887899 981 774970
SGTC_605 1315-0399 119 µM -1.38175960633881 0.0643368307448439 no 3134 0.0835227628005308 1008 24020461
SGTC_1862 st057513 3.81 µM -1.38250636238871 0.064230046919702 no 3135 0.0834081391390173 1001 5393163
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.38268485102606 0.0642045440014211 no 3136 0.0833807594597669 1032 5106787 A p450 inhibitor.
SGTC_1074 carmofur 3.8 µM -1.38644799349656 0.0636686867821349 no 3137 0.082805075073612 1018 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1028 k015-0029 4.8 µM -1.39304502621802 0.0627376987647281 no 3138 0.0818030876661289 1014 4588309
SGTC_1786 berberine 21.6 µM -1.39751011559687 0.0621136193877011 no 3139 0.0811301134519684 957 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_806 3966-4455 5.86 µM -1.40206535706327 0.0614819413288713 no 3140 0.0804478654285236 1001 714982
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.40589910873319 0.060954210653653 no 3141 0.0798770430117395 1008 2374 Ca(2+)-ATPase inhibitor.
SGTC_1303 1160-0052 261 µM -1.40620567903672 0.0609121634570564 no 3142 0.0798315291511537 992 3562476
SGTC_787 4152-0075 138 µM -1.4070322629278 0.0607989075614026 no 3143 0.0797089110761164 992 9566539
SGTC_785 1270-0111 65.3 µM -1.40914421562378 0.060510282377216 no 3144 0.0793962644222459 990 6741994
SGTC_1045 1348-1485 165 µM -1.41052149111423 0.0603226384163659 no 3145 0.079192877588222 1018 6810614
SGTC_2903 5923464 63.88 µM -1.41594142685908 0.0595886301370114 no 3146 0.0783963272328043 1023 2876576
SGTC_277 nystatin 15.5 µM -1.41797798090294 0.0593146408078656 no 3147 0.0780985967360219 1026 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1290 0986-0249 10.2 µM -1.42136762299153 0.0588608041145436 no 3148 0.0776049569185352 1013 53329
SGTC_2414 st077232 92.9 µM -1.42305763617748 0.0586355497381855 no 3149 0.0773597239092573 997 729801
SGTC_2007 4011539 71.82 µM -1.42334591536251 0.0585971939317312 no 3150 0.0773179513675761 1001 45595301
SGTC_1820 st053765 18.6 µM -1.42654515049995 0.0581728538974934 no 3151 0.0768555218915718 1000 3690829
SGTC_1319 1306-0155 43.7 µM -1.42744064874292 0.0580545103354291 no 3152 0.0767264606034744 1010 3122360
SGTC_2431 5490079 200 µM -1.42770161351731 0.0580200584536288 no 3153 0.0766888807822516 1033 5722345
SGTC_1488 4013-0813 75.9 µM -1.42808592302995 0.0579693521808089 no 3154 0.0766335643829086 995 2910057
SGTC_139 0099-0334 718.624 µM -1.42889977273018 0.0578620868252835 no 3155 0.076516521394128 1016 97690
SGTC_2018 5133068 143 µM -1.43380737470324 0.0572185687998836 no 3156 0.0758136199436631 1006 785362
SGTC_2757 clomiphene 4.22 µM -1.43611392202371 0.0569180709031352 no 3157 0.0754849635892808 1025 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_662 k832-1615 104 µM -1.4374120507662 0.056749497494395 no 3158 0.0753004733276478 1016 5878478
SGTC_1369 1866-0067 208 µM -1.44238339087768 0.0561075596212474 no 3159 0.0745971233716066 999 3531355
SGTC_1393 3470-5649 58.2 µM -1.44252954522002 0.0560887740533216 no 3160 0.0745765214502891 1007 4108395
SGTC_1575 cyproterone acetate 48 µM -1.44737359852607 0.0554689582114623 no 3161 0.0738961580163591 1018 9880 An androgen receptor antagonist and liver toxin.
SGTC_258 haloperidol 50.781 µM -1.44956729363141 0.0551900510673267 no 3162 0.0735896110328355 1008 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_214 4373-3496 70 µM -1.45118956854439 0.0549845078949683 no 3163 0.0733635403962796 1022 3779166
SGTC_2241 6772625 37.8075 µM -1.45437059488957 0.0545832263150356 no 3164 0.0729217939237829 993 2285411
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.46261561671046 0.0535539060627567 no 3165 0.0717862937991416 1002 1377
SGTC_2210 7115885 190.385 µM -1.46400944438357 0.0533814281358822 no 3166 0.0715956839353023 1034 2927039
SGTC_527 4476-4215 268 µM -1.46422133338889 0.0533552467164801 no 3167 0.0715667415508523 1003 4418754
SGTC_1870 st057514 26.5 µM -1.47044011395497 0.0525913646702369 no 3168 0.0707212968902284 1016 5393161
SGTC_2784 7567673 72.73 µM -1.47719689642001 0.0517712629280428 no 3169 0.0698114327495573 993 3471247
SGTC_88 0180-0332 8.668 µM -1.48247972471078 0.0511371690947041 no 3170 0.0691063472776627 1009 3101745
SGTC_1759 st043059 70 µM -1.48401878367723 0.0509536041421013 no 3171 0.0689019687385859 1012 669426
SGTC_433 pimozide 108 µM -1.48405917516592 0.0509487936856459 no 3172 0.0688966112532705 1023 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1149 3909-7961 23.3 µM -1.48419871168581 0.0509321782544951 no 3173 0.0688781057443774 1016 735261
SGTC_1949 st076024 69.1 µM -1.49632682683281 0.0495044176989949 no 3174 0.0672842537701624 1021 2921930
SGTC_1134 3477-0009 42.5 µM -1.50411517360418 0.0486045177826406 no 3175 0.0662758569974868 1010 3973534
SGTC_2448 5185112 27.17 µM -1.50687267769932 0.0482890563802723 no 3176 0.0659216480011033 994 5718189
SGTC_2088 5278280 127.392 µM -1.50745141222855 0.0482230569344144 no 3177 0.0658474945475049 1021 791502
SGTC_3351 9150312 21.596 µM -1.50788467935794 0.0481736939858353 no 3178 0.0657920222099881 1027 4904905
SGTC_1150 3909-7983 10.9 µM -1.50986663110179 0.0479484017158245 no 3179 0.06553872939989 1022 23965914
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.51018180423834 0.0479126532246307 no 3180 0.0654985201514127 1015 23665772 A membrane-active detergent.
SGTC_166 k072-0058 166.424 µM -1.51177813999268 0.0477319165343253 no 3181 0.065295156148069 1005 5846229
SGTC_758 0868-0029 16 µM -1.51190852795118 0.0477171781961535 no 3182 0.0652785671346018 997 762687
SGTC_324 1315-0088 19.6 µM -1.51342548322671 0.0475459776091389 no 3183 0.0650858080096592 1027 6787421
SGTC_750 4073-0104 132 µM -1.51542966556102 0.0473205443980454 no 3184 0.0648318147607713 956 22330957
SGTC_3184 9108758 49.47 µM -1.51645347583741 0.0472057157910409 no 3185 0.0647023629606425 1031 902885
SGTC_756 0508-1999 28.3 µM -1.51943719094564 0.0468723415484465 no 3186 0.0643262432708586 1020 6753853
SGTC_1750 st081859 2.357 µM -1.52285338896875 0.0464929670180641 no 3187 0.0638976946789464 1004 5291695
SGTC_2401 5128683 200 µM -1.52973231202203 0.0457365301463618 no 3188 0.0630415010597496 1028 708373
SGTC_624 k048-0052 28 µM -1.53045044527011 0.0456581345821098 no 3189 0.0629526353086588 1032 6835531
SGTC_2773 thioridazine 9.09 µM -1.53062446751054 0.0456391535806191 no 3190 0.0629311155369821 1027 5452 An antipsychotic.
SGTC_2858 9025781 8.96 µM -1.530739092962 0.0456266545876561 no 3191 0.0629169439650618 990 4894980 YPL153C RAD53
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.53384419441366 0.0452891137286337 no 3192 0.0625339938108231 1034 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1069 diphenylcyclopropenone 8.49 µM -1.53458120966704 0.0452092919985299 no 3193 0.0624433655786018 1032 65057 A dermal irritant. YDR527W RBA50
SGTC_3035 9091303 49.47 µM -1.53592805576604 0.0450637155766024 no 3194 0.0622780131559521 1043 25237002
SGTC_1732 st034308 51.822 µM -1.53732980810088 0.0449126053933444 no 3195 0.0621062827668662 1003 830119
SGTC_3167 9103034 49.47 µM -1.53746507335094 0.0448980452817914 no 3196 0.0620897308206926 1039 5127859
SGTC_2702 st077768 96.8 µM -1.54073402424925 0.0445473256830415 no 3197 0.0616907661964478 1010 6484119
SGTC_2008 4012253 172 µM -1.54273953068064 0.0443332532462558 no 3198 0.0614469932013871 994 603940
SGTC_1443 4112-3303 14 µM -1.54698696718196 0.0438826091855396 no 3199 0.060933194177993 1036 704433
SGTC_60 0986-0278 202 µM -1.55036663549184 0.0435266793081745 no 3200 0.0605267709438255 1042 3110598
SGTC_6 0844-0013 19.835 µM -1.55335492943791 0.0432139114256682 no 3201 0.0601691820577369 1050 1584900
SGTC_773 4358-1457 44.6 µM -1.55560603863444 0.0429795012199213 no 3202 0.0599009009532344 1052 1186886
SGTC_1785 bathophenanthroline 24 µM -1.55953426787444 0.0425729122809988 no 3203 0.0594349902365015 968 72812 An iron chelator.
SGTC_724 3910-0327 137 µM -1.56206771441799 0.0423123432182601 no 3204 0.0591360188388697 1034 2885483
SGTC_2987 9018338 71.43 µM -1.56435952620578 0.0420777396087156 no 3205 0.0588665800250058 1022 5055682
SGTC_3319 9138450 16.7555 µM -1.58199230474407 0.0403077551852415 no 3206 0.0568256636111975 1010 2029690
SGTC_3055 9094636 49.47 µM -1.58581931114035 0.0399316983947117 no 3207 0.0563901518770212 1025 25236176
SGTC_360 0957-0399 1.01 µM -1.58691767112427 0.0398242973917784 no 3208 0.0562656460559076 1033 6752301 YPR165W RHO1
SGTC_2236 dapsone 200 µM -1.59048022133662 0.039477555392401 no 3209 0.0558633002144127 1028 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_289 k017-0060 526 µM -1.59061263048112 0.0394647155325612 no 3210 0.0558483901088346 1043 5512909
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.5933282777929 0.0392021247390981 no 3211 0.0555432830891272 1041 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3078 9116413 49.47 µM -1.60043438342178 0.0385217206851947 no 3212 0.0547511262691082 1013 17177322
SGTC_2403 6032726 181.2 µM -1.60319090271663 0.0382603904243769 no 3213 0.0544462566738808 1028 2881040
SGTC_1636 st007707 68.9 µM -1.603482880549 0.0382327945018431 no 3214 0.0544140428793887 1027 403051
SGTC_348 k064-0012 10.7 µM -1.60355625163483 0.038225862477051 no 3215 0.0544059502483467 1022 5066323
SGTC_1414 3917-0015 5.4 µM -1.60459377451995 0.0381279480535741 no 3216 0.0542916161872934 1032 6618702
SGTC_3349 9149703 23.001 µM -1.61160562961413 0.0374715670148605 no 3217 0.0535238924354349 1038 4910494
SGTC_1444 4112-3581 28 µM -1.61355215687381 0.0372909977534095 no 3218 0.0533123007199596 1037 2877249
SGTC_1161 k007-0610 110 µM -1.62265882564892 0.036455638659958 no 3219 0.052331178906347 1012 5843850
SGTC_860 0443-0016 25.1 µM -1.63233904371818 0.035584522111789 no 3220 0.0513040412679151 1038 5337942
SGTC_336 4111-0029 111 µM -1.64027138811438 0.0348834815048606 no 3221 0.0504743759465391 1041 3131175
SGTC_530 4358-1714 28 µM -1.64517726454229 0.0344556151443754 no 3222 0.0499666303131423 1027 1564641
SGTC_192 3455-0609 60.9 µM -1.64895547947409 0.0341290450267926 no 3223 0.0495783779279435 1037 3769639
SGTC_2481 5478948 45.16 µM -1.64974326853547 0.0340612740866795 no 3224 0.0494977282188188 1033 77792
SGTC_947 3447-0010 211 µM -1.65071717137418 0.0339776453820823 no 3225 0.0493981699400245 1033 748350
SGTC_2163 5671233 125 µM -1.66181376769956 0.0330366545494393 no 3226 0.0482750604356185 1013 701023
SGTC_1026 k007-1105 30.6 µM -1.6706076112126 0.0323062810909819 no 3227 0.0473996040673299 1031 7066794
SGTC_269 exalamide 29 µM -1.67131720386557 0.0322479314123044 no 3228 0.0473295200410311 1050 3316 A derivative of salicylamide.
SGTC_2064 5220758 200 µM -1.67339316280805 0.0320777249647569 no 3229 0.0471249614738257 1033 788518
SGTC_194 1486-1323 56.904 µM -1.67411904308267 0.0320183858365297 no 3230 0.0470536029465213 1044 5178754
SGTC_2083 5306046 65.942 µM -1.6750629422548 0.0319413597336616 no 3231 0.0469609414168144 1036 539837
SGTC_1622 st003707 19.4 µM -1.68322662672262 0.0312815343802938 no 3232 0.0461656140677326 1015 10140899
SGTC_1516 st013856 110 µM -1.68680931002503 0.0309955459510819 no 3233 0.0458200123531628 1049 5281404 A mutagen and neurotoxin.
SGTC_1429 4049-0205 9.46 µM -1.69376804410721 0.0304462453122893 no 3234 0.0451546843480175 1037 22774478
SGTC_2451 5856223 45.7 µM -1.69579785494495 0.0302875461957353 no 3235 0.0449620844346561 1033 2179896
SGTC_1717 st033143 58.0435 µM -1.69997129061489 0.0299634028921446 no 3236 0.0445681629156159 1043 674616
SGTC_2962 9082311 13.18 µM -1.70304755621321 0.029726321097673 no 3237 0.0442795845364305 1042 16459453
SGTC_1180 1193-0155 285 µM -1.70940384903536 0.0292413829389787 no 3238 0.0436880842268389 1057 2921347
SGTC_1227 3909-8010 46.6 µM -1.70941344082952 0.0292406561513442 no 3239 0.0436871964807678 1044 15982272
SGTC_2178 5812956 200 µM -1.71267356287479 0.0289944985363926 no 3240 0.0433863057137213 1042 5403383
SGTC_3010 9080089 71.4286 µM -1.71869815934107 0.028544139105039 no 3241 0.0428346736908965 1046 17027233
SGTC_2446 5162541 200 µM -1.71935124557241 0.0284956701339523 no 3242 0.0427752170268167 1058 1549321
SGTC_2423 st077119 87.2 µM -1.73941566942569 0.0270396201962034 no 3243 0.0409808369933273 1036 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1377 2944-0135 198 µM -1.74055653400566 0.0269587297242119 no 3244 0.0408806711328195 1024 1894137
SGTC_1373 2887-0003 58.5 µM -1.74557078891611 0.0266055961908454 no 3245 0.0404427809059731 1045 776948
SGTC_544 k015-0020 52.4 µM -1.74644998167409 0.0265440781459715 no 3246 0.0403663956596947 1047 3008304
SGTC_205 1486-1330 71.903 µM -1.75061258889787 0.0262544272248154 no 3247 0.0400063326591105 1052 4118834
SGTC_2405 ticlatone 3.52 µM -1.75987017742372 0.0256197111691228 no 3248 0.0392149104305354 1032 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_3005 9076496 71.4286 µM -1.76069949616803 0.0255634839994743 no 3249 0.0391446390404283 1047 21368410
SGTC_2811 7967822 32.47 µM -1.76352185127123 0.0253729041126258 no 3250 0.0389062575930843 1031 2232244
SGTC_15 0266-0086 27.098 µM -1.76598578139801 0.0252075013362993 no 3251 0.038699117166592 1068 1712902 YIL048W NEO1
SGTC_1068 loratadine 26.9 µM -1.76625506134058 0.0251894795607865 no 3252 0.0386765336040846 1059 3957 A H1 histamine antagonist.
SGTC_1752 st044819 83.042 µM -1.76690204853995 0.0251462235576519 no 3253 0.0386223169507625 1040 441209 YML126C ERG13
SGTC_1930 st074634 34.3 µM -1.76933199748846 0.0249843186314335 no 3254 0.0384192433225896 1040 684253 YOR116C RPO31
SGTC_2482 5981709 142.65 µM -1.7710395558245 0.0248710694489366 no 3255 0.0382770620743842 1040 877755
SGTC_1959 st077091 55.8 µM -1.77428374540459 0.024657093139786 no 3256 0.0380081139281082 1039 821356 YKL052C ASK1
SGTC_330 1488-0319 80.1 µM -1.77696426788103 0.0244814618389299 no 3257 0.0377870595307249 1037 6846614
SGTC_286 k060-0067 22.9 µM -1.79162033298109 0.0235396421098326 no 3258 0.0365969019088684 1056 5985051
SGTC_1905 st060207 84.5 µM -1.79180169588231 0.0235281811224086 no 3259 0.0365823685401955 1036 1948547
SGTC_21 0849-0113 22.993 µM -1.81758987263094 0.02194563741506 no 3260 0.0345634203326771 1054 1560156
SGTC_2867 9039098 71.43 µM -1.82389084823465 0.0215729282422821 no 3261 0.034084287761999 1032 6463460
SGTC_323 4013-0906 34.3 µM -1.82923081738092 0.0212612647222843 no 3262 0.0336825188173708 1051 2910086
SGTC_3321 9137793 26.8275 µM -1.83308439436453 0.0210387263299312 no 3263 0.0333950107510447 1056 4904192
SGTC_14 0354-0009 295 µM -1.8339607558805 0.0209883937517814 no 3264 0.0333299098935623 1074 1713507
SGTC_1623 st003709 20.3 µM -1.83869661826433 0.020718156232204 no 3265 0.0329799105500677 1043 16192618
SGTC_1094 duloxetine 25.4 µM -1.84084859035252 0.0205963375834407 no 3266 0.0328218749601671 1051 60834 A selective serotonin reuptake inhibitor.
SGTC_1289 0976-0073 69.1 µM -1.84411622957709 0.0204125237629073 no 3267 0.0325831015875914 1060 3391136
SGTC_1504 k297-0033 30 µM -1.84580215967501 0.0203182304354645 no 3268 0.032460468457765 1029 4388117
SGTC_2100 5377183 190 µM -1.84765344163717 0.0202151146316236 no 3269 0.0323262466575908 1028 2844202
SGTC_2274 7947094 46.08 µM -1.84981300838182 0.020095388497243 no 3270 0.0321702526540948 1059 2971028
SGTC_77 0828-0286 12.516 µM -1.85034329979446 0.0200660813441837 no 3271 0.0321320427940877 1042 745345
SGTC_416 estradiol valerate 100 µM -1.85450663639707 0.0198372470377059 no 3272 0.03183335579737 1065 13791 A steroid.
SGTC_1017 4239-0030 168 µM -1.85644359112025 0.0197315411392826 no 3273 0.0316951781457002 1049 1149593
SGTC_1713 st033146 12.748 µM -1.8600570577609 0.0195356203780854 no 3274 0.0314387269064718 1062 674619
SGTC_3355 9151058 44.0485 µM -1.87491198743602 0.0187474589867153 no 3275 0.0304024163213142 1073 17015728
SGTC_524 r073-0010 27.8 µM -1.8778387790256 0.0185954051455903 no 3276 0.0302016117489021 1054 2772106
SGTC_2710 st078562 53.7235 µM -1.8836880879598 0.0182946636386219 no 3277 0.0298035893271007 1059 17250908
SGTC_1233 0325-0408 14.2 µM -1.88456857259948 0.0182497544224289 no 3278 0.0297440543345688 1056 12874
SGTC_2350 9023895 38.85 µM -1.89644466664412 0.0176531330760829 no 3279 0.0289506351335314 1040 2997209
SGTC_1964 st076914 61 µM -1.90134408444335 0.0174118945840326 no 3280 0.0286284791629762 1059 24208661
SGTC_2643 anethole 100 µM -1.90360320496767 0.0173016113220916 no 3281 0.0284809405525081 1065 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1107 amlodipine 47 µM -1.90498476515966 0.0172344622853215 no 3282 0.0283910257486377 940 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_496 calpeptin 138 µM -1.92411032028553 0.0163275252600987 no 3283 0.027170378378249 1051 73364 A calpain inhibitor.
SGTC_2931 9014674 55.67 µM -1.92702899180558 0.0161927806661045 no 3284 0.0269880084839875 1065 2996810
SGTC_1729 st035615 45.989 µM -1.9317313015515 0.0159776958523568 no 3285 0.0266963395993351 1042 17385451
SGTC_1285 0929-0069 65.5 µM -1.93857634039688 0.0156689816609369 no 3286 0.0262764734020177 1068 1206237
SGTC_207 4185-0010 4.486 µM -1.95344094670762 0.0150161630046155 no 3287 0.0253836841484107 1051 3761753
SGTC_1392 3455-1037 33.9 µM -1.95535616798516 0.0149337754209736 no 3288 0.0252705229335863 1054 981132
SGTC_1159 4092-0538 61.2 µM -1.96695456321248 0.0144431011565681 no 3289 0.0245942246270598 1063 717301
SGTC_159 3970-0959 50 µM -1.96901022369755 0.014357599420389 no 3290 0.0244759585352128 1048 6615653
SGTC_122 0236-0016 402.397 µM -1.97901304468255 0.0139477422635723 no 3291 0.023907268798106 1041 6808838
SGTC_1658 st012944 20 µM -1.992851100022 0.0133973927633074 no 3292 0.023138877146157 1061 24207260
SGTC_2365 9042475 200 µM -2.00530895927985 0.0129180763633947 no 3293 0.0224650138076591 1046 6464479
SGTC_125 0133-0007 11.75 µM -2.016538393982 0.0124988040531196 no 3294 0.0218718538231334 1059 26541
SGTC_1152 3909-8331 15.9 µM -2.02038921197707 0.012357765037485 no 3295 0.0216715157760285 1052 16001939
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -2.03117362276261 0.0119700912980968 no 3296 0.0211186925666879 1049 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2441 5730946 39.09 µM -2.04214062161755 0.0115867147530648 no 3297 0.020568792225349 1062 1774275
SGTC_3085 9117376 49.47 µM -2.05335935953933 0.0112056147459336 no 3298 0.0200188688841776 1057 16480349
SGTC_2623 humulene 100 µM -2.0602784449873 0.0109760466282847 no 3299 0.0196859646739556 1070 6187145 An anti-inflammatory.
SGTC_2417 cerulenin 830 nM -2.07237502232686 0.0105845154539264 no 3300 0.0191152404379514 1063 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1463 k081-0032 34.1 µM -2.07307672506549 0.0105621814874325 no 3301 0.0190825698531475 1014 977755
SGTC_1724 st037281 8.293 µM -2.07688776971975 0.0104415982575196 no 3302 0.0189059594098539 1053 574124 YDL195W SEC31
SGTC_2502 avocadyne acetate 18.59 µM -2.08005044681497 0.0103424424355331 no 3303 0.0187604530110848 1054 3952079
SGTC_1450 4112-4260 37.6 µM -2.08953906603525 0.0100498665027965 no 3304 0.0183296125702292 1063 1633175
SGTC_726 3448-4391 34.2 µM -2.1000857483108 0.00973316624478778 no 3305 0.0178606493833141 1068 1356692
SGTC_2089 5281248 129.67 µM -2.10781632186497 0.00950660061107405 no 3306 0.0175234402344783 1065 2737878
SGTC_1609 st001574 46.4 µM -2.10844655013926 0.00948833498298384 no 3307 0.0174961907516554 1060 3960012
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -2.10854357824177 0.00948552558793257 no 3308 0.0174919987162061 1044 4330530
SGTC_1336 1486-0901 104 µM -2.11349366545759 0.00934316030454117 no 3309 0.0172792683112605 1065 5006114
SGTC_1282 0886-0010 32.4 µM -2.13564557847602 0.00872872514260432 no 3310 0.0163541566859225 1060 2836211 YNL267W PIK1
SGTC_2464 5717415 7.67 µM -2.13876255453847 0.00864517558211737 no 3311 0.0162274517682437 1077 5285744
SGTC_418 lividomycin a 100 µM -2.17605699373611 0.00769861232416119 no 3312 0.0147754995742893 1072 72394 An antibiotic.
SGTC_613 3914-0030 117 µM -2.17956985893075 0.00761433954972677 no 3313 0.0146446805322755 1048 1145395
SGTC_178 4092-0806 87.505 µM -2.24535028165881 0.00617953756629333 no 3314 0.0123728272429662 1044 2169044
SGTC_1682 st012968 530 nM -2.25333241655835 0.00602285317923161 no 3315 0.0121190986466265 1060 24207270
SGTC_834 0312-0008 75.7 µM -2.30007630370898 0.00517404116502538 no 3316 0.0107219487532892 1082 6385573 YIL048W NEO1
SGTC_2484 5809818 12.04 µM -2.3757533217122 0.00402385874628828 no 3317 0.00875658321869676 1074 2870548
SGTC_121 0557-0495 61.343 µM -2.38046785696356 0.00396043610856144 no 3318 0.00864533472148044 1087 3104427
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -2.38470336000899 0.00390422274780657 no 3319 0.0085464489604811 1079 16725076
SGTC_3210 9128157 49.47 µM -2.3883368066449 0.00385657063200622 no 3320 0.00846241155871387 1059 17590849
SGTC_2283 7944793 200 µM -2.40522539609338 0.00364185159970082 no 3321 0.00808124687606602 1066 2970533
SGTC_296 1222-0039 74.9 µM -2.40567812007852 0.00363624635751582 no 3322 0.00807124027418893 1083 5984176
SGTC_2333 9017922 200 µM -2.44390320999802 0.00318999536781703 no 3323 0.00726466195563473 1071 3163164
SGTC_2677 mitomycin C 100 µM -2.44413856959034 0.003187407535009 no 3324 0.00725992423117774 1093 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1441 4106-0040 13 µM -2.44480871035709 0.00318004952728109 no 3325 0.00724644939901072 1086 2904180
SGTC_1459 k035-0031 35.7 µM -2.45110250826034 0.0031116872629094 no 3326 0.00712096940420257 1067 3877128 YMR208W ERG12
SGTC_2085 5307070 144.047 µM -2.48661965451546 0.00275011932295791 no 3327 0.00644815966794528 1085 2840351
SGTC_123 0083-0120 66.675 µM -2.49025586864772 0.00271532994068012 no 3328 0.00638255797999741 1087 16001701
SGTC_1627 st003713 25.6 µM -2.51306719153197 0.00250600094533841 no 3329 0.00598432684698393 1074 16195070 YER133W GLC7
SGTC_246 cycloheximide 667 µM -2.52707602442038 0.00238479348053558 no 3330 0.00575083011188427 1081 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_693 4161-2696 114 µM -2.62772222254395 0.00165869834528583 no 3331 0.00429793381620265 1086 805759
SGTC_1612 st002233 45.4 µM -2.65443411971499 0.0015032527039237 no 3332 0.00397207751852047 1078 1035021
SGTC_3000 9075062 71.4286 µM -2.69614921634146 0.00128691159322287 no 3333 0.00350731180516159 1068 17057871
SGTC_852 0418-0143 439 µM -2.77590034846653 0.000950608089995935 yes 3334 0.00275245391176509 1056 5369229
SGTC_836 0330-0104 1.35 µM -2.7836741301373 0.000922572965181983 yes 3335 0.00268735017914335 1089 46494820
SGTC_2023 5144124 124 µM -2.81407309253238 0.000820082575581286 yes 3336 0.0024459052105859 1076 2830192
SGTC_1213 1315-0166 115 µM -2.82385147453435 0.000789411387479175 yes 3337 0.00237251839659028 1086 768401
SGTC_1353 1498-1206 8.11 µM -2.85760144392276 0.000691482217787899 yes 3338 0.00213428083345074 1007 6756808
SGTC_126 0417-1624 672.48 µM -2.89738344681516 0.000590485164717899 yes 3339 0.00188144764194817 1085 41912 YDL195W SEC31
SGTC_399 oxolinic acid 75 µM -2.89966623645226 0.000585125329446347 yes 3340 0.0018678010004921 1087 4628 A DNA gyrase inhibitor.
SGTC_118 0083-0097 135.343 µM -2.97249917693672 0.000435973664498634 yes 3341 0.00147693001080934 1090 5207356
SGTC_2486 5283202 22.39 µM -3.01433405484305 0.000367108144188095 yes 3342 0.00128772029527374 1089 1377751
SGTC_1123 mangostin 811.285 nM -3.01969589023333 0.000359052106704934 yes 3343 0.00126514303721064 1080 5281650 An antioxidant.
SGTC_1168 k815-0004 80.5 µM -3.1405578433672 0.000215726627540331 yes 3344 0.000843132021009805 1090 642433
SGTC_1235 benzylparaben 21.5 µM -3.32158867126105 9.72760522755625e-05 yes 3345 0.000447532684998658 1095 7180
SGTC_1043 0916-0009 19.3 µM -3.51222174973881 4.02611386754233e-05 yes 3346 0.000222188527345041 1093 3101130
SGTC_2098 5376439 882.5 nM -3.52472324446678 3.79387389148872e-05 yes 3347 0.000211962719486157 1092 2844116
SGTC_1457 k015-0032 57.3 µM -3.53306944128834 3.6459416876329e-05 yes 3348 0.000205382281852143 1094 4302660
SGTC_1730 st033808 45.1 µM -3.57607994823185 2.96622642670611e-05 yes 3349 0.000174392512796091 1089 1045166
SGTC_668 1682-0499 62.6 µM -3.68540416873999 1.73772297901976e-05 yes 3350 0.000114169994992778 1094 682214
SGTC_1629 st005085 44.9 µM -3.74723528785427 1.27584924284526e-05 yes 3351 8.93971803590974e-05 1091 24207091
SGTC_1228 0124-0032 52.5 µM -3.90325077885217 5.72905327400068e-06 yes 3352 4.74546365371338e-05 1094 X1228
SGTC_371 0195-0006 7.36 µM -4.55047387456414 1.49644408748976e-07 yes 3353 2.67626165080695e-06 1077 3928593
SGTC_1638 st008370 60.6 µM -5.04548002142909 6.46513194512428e-09 yes 3354 2.26192082659838e-07 1094 24207134
SGTC_423 5-fluorouracil 457 µM -5.17727450834811 2.65896203445983e-09 yes 3355 1.12575408274573e-07 1093 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.