SGTCid condition conc unit TRI1|YMR233W.score TRI1|YMR233W.strain.pval TRI1|YMR233W.strain.significant TRI1|YMR233W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1735 st034310 56.75 µM 5.91625108713981 8.41745368030657e-09 yes 1 1.64681147628534e-09 4 871153
SGTC_2779 methotrexate 400 µM 5.45675086945173 9.83860960234361e-08 yes 2 2.42462988271376e-08 15 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_364 0083-0097 67.7 µM 5.43567691446271 1.09635710888191e-07 yes 3 2.72943955229781e-08 9 5207356
SGTC_258 haloperidol 50.781 µM 5.33951095024796 1.78788652829952e-07 yes 4 4.65988204377026e-08 11 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1915 st067105 30.6 µM 5.16592487786473 4.23365510348319e-07 yes 5 1.19626438210686e-07 15 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 4.88199701188496 1.63738977328249e-06 yes 6 5.25084240009084e-07 10 3256 An antibiotic and ribosome inhibitor.
SGTC_2980 9014342 25.29 µM 4.85680687725013 1.83983506908026e-06 yes 7 5.96469198665539e-07 18 2996599
SGTC_2719 novobiocin 32.65 µM 4.72249572138415 3.39330007464722e-06 yes 8 1.1648399614348e-06 1 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2274 7947094 46.08 µM 4.6982184023387 3.78389879338985e-06 yes 9 1.31220355965274e-06 12 2971028
SGTC_887 0885-0007 9.62 µM 4.65560356252829 4.5756562952334e-06 yes 10 1.61516489911869e-06 24 5719458
SGTC_2486 5283202 22.39 µM 4.57781710754636 6.44590306674242e-06 yes 11 2.34926603598851e-06 27 1377751
SGTC_2905 7799065 20.05 µM 4.46181418088588 1.06403079612489e-05 yes 12 4.06343419807324e-06 8 1296806
SGTC_1480 1070-0044 41.2 µM 4.39030470333449 1.4407428422095e-05 yes 13 5.65959682564307e-06 12 3124987
SGTC_1708 st033234 31.827 µM 4.32781581657389 1.87078488449528e-05 yes 14 7.52976596205486e-06 9 674664
SGTC_3129 9127257 49.47 µM 4.27831410380713 2.2952693910116e-05 yes 15 9.41570820824337e-06 15 837894
SGTC_2473 5854593 8.94 µM 4.21514836538401 2.97035954382463e-05 yes 16 1.24807017854131e-05 6 2872951
SGTC_972 1319-0219 195 µM 4.19309743687602 3.24745664355768e-05 yes 17 1.37585589329883e-05 19 23903702
SGTC_2431 5490079 200 µM 4.10745653043776 4.57334730009747e-05 yes 18 2.00020018007312e-05 29 5722345
SGTC_1763 st044482 94.5 µM 4.05637867204134 5.59237662604306e-05 yes 19 2.49197166001977e-05 19 88505
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 4.01124885209571 6.6675401498775e-05 yes 20 3.01992026586368e-05 17 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3352 9151559 45.5865 µM 4.00993287465426 6.7016388723827e-05 yes 21 3.0368005812762e-05 12 17159339
SGTC_174 3553-0389 74.3 µM 3.95972152999436 8.13245202061591e-05 yes 22 3.75186048759607e-05 22 738071
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 3.93726274806768 8.86143400134526e-05 yes 23 4.12081751393772e-05 21 688761
SGTC_1389 3405-0187 19 µM 3.92558655864936 9.26428476802632e-05 yes 24 4.32593251892521e-05 15 799890
SGTC_459 nigericin 15.3 µM 3.8637926979958 0.000116987781748482 yes 25 5.58199879294827e-05 65 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2636 apigenin dimethyl ether 100 µM 3.83781725166751 0.000128915711863658 yes 26 6.20664030453382e-05 51 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2370 9071495 200 µM 3.82271309595342 0.000136366429337483 yes 27 6.59956624436816e-05 30 21791103
SGTC_2113 5491891 107.031 µM 3.81793620637732 0.000138805591683857 yes 28 6.72863551678104e-05 24 789979
SGTC_2977 9011197 71.43 µM 3.81557014219045 0.000140028829914189 yes 29 6.79344264455955e-05 20 2704722
SGTC_1272 0839-0021 27 µM 3.81462362019363 0.000140520997912856 yes 30 6.8195324401124e-05 22 5027250
SGTC_685 1278-0033 54.9 µM 3.7950688179853 0.000151058920975451 yes 31 7.38012544576614e-05 24 3590572
SGTC_1045 1348-1485 165 µM 3.7706820608309 0.0001652382186311 yes 32 8.14009902784331e-05 35 6810614
SGTC_2595 hexamethylquercetagetin 100 µM 3.75903293547296 0.000172442457983975 yes 33 8.52856925444738e-05 32 386331
SGTC_2250 alverine citrate 130 µM 3.75398309449708 0.000175655865478243 yes 34 8.70233035709808e-05 171 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_901 1112-0062 60.1 µM 3.75223376067656 0.000176782033930984 yes 35 8.76329610563985e-05 12 1908457
SGTC_612 0302-0167 22.4 µM 3.61050028672091 0.00029410359590194 yes 36 0.000152803481969644 48 235821
SGTC_1974 st069448 26.9 µM 3.60750260246162 0.000297231367156828 yes 37 0.000154579219082608 31 6323587 YNR016C ACC1
SGTC_641 4092-0595 30 µM 3.58499085187528 0.000321728272339878 yes 38 0.000168545010380986 18 786260
SGTC_1442 4112-3290 3 µM 3.52897326600986 0.000391069677279342 yes 39 0.000208587635871375 25 704353
SGTC_2345 9052315 157.45 µM 3.47658736901989 0.000468235391115031 yes 40 0.00025391936797555 33 6469265
SGTC_1374 2889-5571 141 µM 3.46475095098385 0.000487521622061582 yes 41 0.000265361359636716 62 2853281
SGTC_2848 9016370 25.97 µM 3.44747366072612 0.000516996670323605 yes 42 0.000282927789190936 47 7894410
SGTC_2368 9071271 200 µM 3.43945489390946 0.000531229571081831 yes 43 0.000291443453834329 56 27209959
SGTC_1581 himbacine 57.9 µM 3.40790517875984 0.000590820052459331 yes 44 0.000327318193549107 62 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2477 5967686 25.23 µM 3.38129823984432 0.000645812913994893 yes 45 0.000360720961949158 44 776118
SGTC_1844 rapamycin 4 nM 3.36933547592305 0.000672046168172918 yes 46 0.000376748295123412 206 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2357 9067248 200 µM 3.28606054970878 0.000883694945980699 yes 47 0.000507995838544184 46 9150235
SGTC_1762 st045503 25.4615 µM 3.18796689058408 0.00121078879074426 no 48 0.000716384706826969 56 4645554
SGTC_1737 st035557 69.7 µM 3.15696316223924 0.0013352269638157 no 49 0.000797107424382648 38 5716916
SGTC_733 4069-0007 56.1 µM 3.15345373465207 0.00135002547177783 no 50 0.000806754010749604 130 5717425 YNL287W SEC21
SGTC_659 k018-0002 107 µM 3.15155235843506 0.00135810562040154 no 51 0.000812025212178424 45 6797879 YHR007C ERG11
SGTC_3155 9099265 49.47 µM 3.12846161356166 0.00145982188926263 no 52 0.000878619812908099 59 25236499
SGTC_544 k015-0020 52.4 µM 3.12170262970052 0.00149088459580026 no 53 0.000899042305282952 41 3008304
SGTC_2865 9030313 51.95 µM 3.1137334313888 0.00152828318216816 no 54 0.00092368155925649 40 42562754
SGTC_2600 tangeritin 87.95 µM 3.07027734587501 0.00174769420882038 no 55 0.00106930038215002 71 68077 A bioactive flavone.
SGTC_1096 rimcazole 32.2 µM 3.0685234832017 0.00175712336713874 no 56 0.00107559710282549 38 18528119 A dopamine reuptake inhibitor.
SGTC_822 1487-0950 154 µM 3.06371766011046 0.00178319822853719 no 57 0.00109302557981586 47 1958375
SGTC_3068 9116768 49.47 µM 3.03562996500296 0.00194276021541491 no 58 0.0012001687493389 57 41904888
SGTC_2362 9071156 126 µM 3.01982334303514 0.0020381555956359 no 59 0.00126461080025562 43 653133
SGTC_3150 9097574 49.47 µM 3.00568992892165 0.00212703205329807 no 60 0.00132489526768646 32 17217476
SGTC_1734 st037168 69.4 µM 3.00010175722018 0.00216313175069067 no 61 0.00134944712788376 73 708907
SGTC_3006 9075424 71.4286 µM 2.98614058811125 0.00225576111857601 no 62 0.00141261362455509 48 7465181
SGTC_105 0111-0055 734.78 µM 2.98259940349777 0.00227982046621152 no 63 0.00142905909438014 39 5179370
SGTC_3128 9127691 49.47 µM 2.96712680478956 0.00238769332937554 no 64 0.00150298478706861 53 41316314
SGTC_3335 9143315 29.6265 µM 2.93578309323511 0.00262048978416081 no 65 0.00166353437588675 51 4899691
SGTC_2639 lactacystin 53 µM 2.91850715246394 0.00275739089967747 no 66 0.00175855903239523 76 3870 A proteasome inhibitor.
SGTC_593 1203-0218 61.7 µM 2.88457535860929 0.00304521746524386 no 67 0.00195970970252452 52 3666956
SGTC_301 4119-0100 24.5 µM 2.87381228627028 0.00314201238196581 no 68 0.00202774961256876 139 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_674 0498-0004 451 µM 2.850598423787 0.00336026783045362 no 69 0.00218185213332451 71 4231473
SGTC_2481 5478948 45.16 µM 2.83557144014506 0.00350872193611988 no 70 0.00228718915253913 108 77792
SGTC_2959 9079155 11 µM 2.82262306434847 0.0036413368868439 no 71 0.00238162685653413 80 16189457
SGTC_1574 spiramycin 23.7 µM 2.81151338669088 0.00375868649352081 no 72 0.00246545194186692 86 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2725 haloperidol 53.21 µM 2.80917011699685 0.00378386690116075 no 73 0.00248346965256941 109 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_663 1486-0733 13.9 µM 2.80731981914064 0.00380385665894147 no 74 0.00249778088133133 117 722445 YPR165W RHO1
SGTC_2237 6667747 47.222 µM 2.8070606842391 0.00380666377661368 no 75 0.00249979111649672 57 729940 YDL015C TSC13
SGTC_2698 st077697 67.5 µM 2.78198139521499 0.004087286206131 no 76 0.00270140686143591 63 3154499
SGTC_830 4076-0286 57.8 µM 2.75998134781142 0.00434854797865061 no 77 0.00289023308620912 193 6866659
SGTC_1982 st072467 71.9 µM 2.75592543608784 0.00439831168102802 no 78 0.00292631686125243 117 3163533
SGTC_2610 ononetin 44.17 µM 2.7558838893081 0.00439882405808831 no 79 0.0029266885777671 124 259632
SGTC_2864 9034755 47.6 µM 2.75170377941722 0.00445064881354164 no 80 0.00296430605767818 65 4930451
SGTC_1520 flindersine 88 µM 2.74964018814828 0.00447643361452859 no 81 0.00298303682585984 104 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_723 4182-0001 115 µM 2.73363544969159 0.00468098688753278 no 82 0.00313196768446866 72 744821 YLR208W SEC13
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 2.73178160315381 0.00470521142487718 no 83 0.00314964411982707 150 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2851 9015922 71.43 µM 2.70953571185001 0.00500474632502717 no 84 0.00336887256468073 115 2996893
SGTC_1126 isoteolin 1.0172 µM 2.70789948629507 0.00502743400794091 no 85 0.00338552629168335 105 133323
SGTC_1339 1486-1321 22.7 µM 2.64309323843661 0.00600297223403403 no 86 0.00410762045714517 103 3469382
SGTC_1457 k015-0032 57.3 µM 2.63936189395645 0.00606393564002448 no 87 0.00415311294924597 129 4302660
SGTC_927 2425-1185 123 µM 2.63634746792615 0.00611358592201595 no 88 0.00419019339579457 100 730375
SGTC_2985 9022375 71.43 µM 2.63478923895932 0.00613939229363088 no 89 0.00420947703396555 115 4939335
SGTC_2062 5245942 200 µM 2.62290445315219 0.00633941601175029 no 90 0.00435918593384094 104 1376160
SGTC_2700 st077718 96.8 µM 2.61271616985884 0.00651545702356178 no 91 0.0044912933049579 67 904970
SGTC_2080 5212524 12.4 µM 2.60770548805498 0.0066036111140098 no 92 0.00455756709767266 73 260183
SGTC_1789 tunicamycin 25 nM 2.60362109031473 0.00667624732642469 no 93 0.00461223378226958 133 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_256 clotrimazole 625 nM 2.60017577549115 0.00673806635404059 no 94 0.00465880101613496 125 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_606 k015-0008 38.6 µM 2.59980518189323 0.00674474592410497 no 95 0.0046638349023537 102 1970475
SGTC_1557 sumaresinolic acid 42.3 µM 2.54936756275135 0.00771024547908672 no 96 0.00539592457895831 109 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3056 9094900 49.47 µM 2.54047193035941 0.00789260801800786 no 97 0.00553514897042675 114 25236784
SGTC_814 3342-0569 96 µM 2.53320562177846 0.00804437318576608 no 98 0.00565123152530103 126 4346283
SGTC_2963 9082507 9 µM 2.52399834721998 0.00824035826086282 no 99 0.00580142370685737 106 16459611
SGTC_2177 5811945 192 µM 2.51893853697687 0.00834983663372083 no 100 0.00588546009440295 107 5343475
SGTC_179 1273-0063 6.77 µM 2.51867431557522 0.00835558847621311 no 101 0.00588987795685118 102 3108139
SGTC_2337 9009472 200 µM 2.51605021511354 0.00841290168987337 no 102 0.00593391362941892 142 5742383
SGTC_310 1273-0058 1.06 µM 2.50262781735284 0.00871149073610191 no 103 0.00616375517597783 441 2734232
SGTC_828 2074-0507 139 µM 2.4926571113059 0.00893927101207389 no 104 0.00633956113874682 122 X828
SGTC_682 0kpi-0099 17 µM 2.48633083086781 0.00908648541285497 no 105 0.00645339587925679 175 1714895 YML126C ERG13
SGTC_1427 4048-4900 550 nM 2.46365332235869 0.00963178349164577 no 106 0.00687645303921493 116 24132586
SGTC_2831 7999036 19.48 µM 2.45155710278169 0.00993418009875291 no 107 0.00711198079203017 178 2988270
SGTC_2266 7929956 200 µM 2.44846312077523 0.0100128460628292 no 108 0.00717335581152272 132 2967153
SGTC_793 0488-0545 106 µM 2.43456917818503 0.0103728462501449 no 109 0.00745476479110341 127 292548
SGTC_445 e6 berbamine 66 µM 2.42881919410631 0.01052510162435 no 110 0.00757404224116756 273 6610268 A calcium/calmodulin antagonist.
SGTC_667 1498-1044 59 µM 2.42624631359017 0.0105938578319207 no 111 0.00762795604546287 133 6739982
SGTC_2671 danthron 100 µM 2.42236570351107 0.0106983011344577 no 112 0.00770991203356297 158 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2417 cerulenin 830 nM 2.41776296421661 0.0108233414299477 no 113 0.00780812291006484 116 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_997 3996-0078 137 µM 2.39446353965832 0.0114760120134907 no 114 0.00832234910943649 154 735687
SGTC_1254 0550-0035 264 µM 2.39057415968268 0.0115882286636334 no 115 0.00841102572824669 135 15121435
SGTC_1958 st076513 41.9 µM 2.39023667331075 0.0115980106166798 no 116 0.00841875927503526 164 732122 YGL099W LSG1
SGTC_166 k072-0058 166.424 µM 2.37981540656168 0.0119036175605173 no 117 0.00866065625992262 140 5846229
SGTC_281 1672-3440 14.9 µM 2.37222845209683 0.0121304788761998 no 118 0.00884057729088835 99 6833000
SGTC_1469 k284-2957 126 µM 2.36542828464688 0.01233698957243 no 119 0.00900461542866003 111 23884841
SGTC_2210 7115885 190.385 µM 2.35020797772662 0.0128102723867849 no 120 0.00938146198831904 144 2927039
SGTC_826 1683-5028 118 µM 2.34642129348557 0.0129304326894551 no 121 0.00947733450856253 122 722377
SGTC_2506 ethyl hematommate 54.16 µM 2.333483022771 0.0133483772277913 no 122 0.00981140417422448 125 3940691 An allergen.
SGTC_576 1073-0113 22.7 µM 2.33008519695346 0.0134600525886446 no 123 0.00990082432656431 243 5439563
SGTC_2846 9008642 19.48 µM 2.32671994969552 0.0135714513497536 no 124 0.00999008767752992 121 2992898
SGTC_2191 5911152 200 µM 2.31941387029675 0.0138160442963447 no 125 0.0101863031463522 131 2875902
SGTC_2154 5570129 200 µM 2.30964634938292 0.0141489738349226 no 126 0.0104538706648644 152 673366
SGTC_2088 5278280 127.392 µM 2.30553785463114 0.014291065411034 no 127 0.0105682346088125 180 791502
SGTC_2010 4012422 159 µM 2.29978912502458 0.0144919461561915 no 128 0.0107300849338552 155 952393
SGTC_2674 ligustilide 100 µM 2.29176463061579 0.0147764115377202 no 129 0.0109596143353635 102 5319022 A signalling regulator.
SGTC_726 3448-4391 34.2 µM 2.27568211215449 0.0153610131340752 no 130 0.0114325213711964 158 1356692
SGTC_1330 1469-0054 61.8 µM 2.25842096531035 0.0160104463844618 no 131 0.0119597134317194 142 7102664
SGTC_1099 5-nonyloxytryptamine 2.85 µM 2.25328706110632 0.0162080887366133 no 132 0.0121205275245511 146 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1288 0973-0013 65.5 µM 2.24582802935307 0.0164989651390563 no 133 0.0123575126075484 155 4315430
SGTC_353 1988-1175 58.3 µM 2.22857615311788 0.0171888932557367 no 134 0.0129210595968036 149 2788357
SGTC_187 1488-2104 32.728 µM 2.22567942662118 0.0173071220589755 no 135 0.0130178308848611 175 2852859
SGTC_797 k781-0471 270 µM 2.22494624126101 0.0173371566664474 no 136 0.0130424236303246 160 23738129
SGTC_2589 lobaric acid 100 µM 2.22359891107593 0.0173924655179596 no 137 0.0130877209467852 181 73157 A novel microtubule depolymerizer.
SGTC_3248 9135562 49.47 µM 2.21976379680103 0.0175507252379206 no 138 0.013217402826308 134 17650701
SGTC_2586 curcumin 80 µM 2.20677264377809 0.0180959840816692 no 139 0.0136649735835557 245 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_695 3505-6186 243 µM 2.20455144724441 0.0181906420999197 no 140 0.0137427930055935 157 1819379
SGTC_1208 2323-2347 50.3 µM 2.20114814586939 0.0183364948873284 no 141 0.0138627689122899 137 5412760
SGTC_16 erodoxin 22.806 µM 2.19999228661777 0.0183862568045546 no 142 0.0139037211449143 242 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1819 st053448 58.6 µM 2.19957733149059 0.018404149442799 no 143 0.0139184484797311 157 2857616
SGTC_2377 9073351 62.6 µM 2.19336797713346 0.0186736698502526 no 144 0.0141404387940062 177 7337946 YHR072W ERG7
SGTC_1531 st059297 52.4 µM 2.18869390415358 0.018878760242597 no 145 0.0143095476733602 171 7566702
SGTC_2378 9074213 121.43 µM 2.18715472304814 0.0189467149526144 no 146 0.0143656154493159 185 657714
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 2.17195523046008 0.0196290146567951 no 147 0.0149295199677699 183 94937 An inhibitor of serotonin biosynthesis.
SGTC_487 nimodipine 119 µM 2.17119744484657 0.0196635705087806 no 148 0.01495812521511 95 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2265 7929201 200 µM 2.15300071029605 0.0205090053608099 no 149 0.0156593113572462 187 1265108
SGTC_3204 9114183 49.47 µM 2.15073860523081 0.0206162259927697 no 150 0.0157484187081153 188 17027248
SGTC_406 estrone 100 µM 2.14916710214492 0.0206909922393455 no 151 0.0158105780440527 145 5870 A steroid.
SGTC_2715 st079500 56.4 µM 2.14072861747334 0.021096402068576 no 152 0.0161479646663191 146 28246688
SGTC_1481 3346-2004 36 µM 2.13937615543292 0.0211619992022821 no 153 0.0162026082377106 160 2770522
SGTC_1422 4031-0024 15.5 µM 2.13568938480903 0.0213416918368651 no 154 0.0163523701079068 153 782427
SGTC_1868 st057644 42.7 µM 2.13545257716 0.0213532777701737 no 155 0.0163620299564743 209 688665
SGTC_2951 9072950 58.06 µM 2.13294649690611 0.0214762152902606 no 156 0.0164645577301677 206 16488155
SGTC_2369 9071472 200 µM 2.13286794742761 0.0214800782399823 no 157 0.0164677801854664 189 17296037
SGTC_2973 9094665 17.96 µM 2.13204694928022 0.0215204889035584 no 158 0.0165014935736798 228 25237061 YIL048W NEO1
SGTC_1462 k081-0014 26.5 µM 2.12875640413222 0.0216830995467652 no 159 0.0166372097735445 110 3270634
SGTC_2052 5265182 7.135 µM 2.12628535920428 0.0218058939227498 no 160 0.0167397531814724 196 1239884
SGTC_438 sphingosine 6.67 µM 2.1182629526514 0.0222086099728065 no 161 0.0170764021636536 154 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1185 1319-0113 81.3 µM 2.1095672559717 0.0226521943989591 no 162 0.0174478236162763 152 4672763
SGTC_3097 9117246 49.47 µM 2.10403063386114 0.022938501656595 no 163 0.0176878874418938 199 16423892
SGTC_1534 6-azauridine 81.6 µM 2.09747694830314 0.0232813365747169 no 164 0.0179756878408425 223 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3291 9121177 71.43 µM 2.09585652300529 0.023366765784876 no 165 0.0180474602451784 164 17015612
SGTC_2940 9060638 45.86 µM 2.08981311576011 0.0236877057346247 no 166 0.0183172953541817 214 4027022
SGTC_709 3807-1509 243 µM 2.08114223649973 0.0241546480203012 no 167 0.0187104444303673 138 1886677 YPL242C IQG1
SGTC_3275 9138069 49.47 µM 2.07460436902363 0.0245118154271848 no 168 0.0190116084287277 157 17617007
SGTC_312 4092-0653 6.84 µM 2.07446750708251 0.0245193393870715 no 169 0.0190179567123392 288 1148278
SGTC_1736 st036774 51 µM 2.05577689931294 0.0255652164025765 no 170 0.0199020128346275 215 1272247
SGTC_346 4513-0042 7.16 µM 2.02874187783673 0.027143914887628 no 171 0.0212422940266378 239 2827372
SGTC_1390 3413-2614 145 µM 2.02689042597969 0.0272549424622198 no 172 0.0213368099324857 238 3421432
SGTC_2952 9073731 13.78 µM 2.01949426286685 0.0277022606680161 no 173 0.0217179365054789 262 16457353
SGTC_2702 st077768 96.8 µM 2.01799813663765 0.0277934860361518 no 174 0.021795727694794 196 6484119
SGTC_596 1155-0152 116 µM 2.0104510464362 0.0282574892388652 no 175 0.0221917362177725 282 280313
SGTC_2747 doxorubicin 7.63 µM 2.01028555931914 0.0282677353693921 no 176 0.0222004871869987 95 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3215 9129942 49.47 µM 1.99878938347168 0.0289871272024517 no 177 0.0228155734812759 170 17682944
SGTC_2389 9091542 195.52 µM 1.99153415716682 0.0294489177822466 no 178 0.0232110969469333 246 3626624 YOL127W RPL25
SGTC_1030 k029-0042 36.7 µM 1.99125611284425 0.0294667359538153 no 179 0.0232263688496928 262 6080581
SGTC_2290 7904846 200 µM 1.98873736474938 0.0296285553491385 no 180 0.0233650997389925 244 2962154
SGTC_2283 7944793 200 µM 1.98720084653876 0.0297276321213424 no 181 0.0234500720464002 256 2970533
SGTC_1855 st056195 39.6 µM 1.98519310480136 0.0298575081565314 no 182 0.023561495585096 220 4028379
SGTC_123 0083-0120 66.675 µM 1.98326886487053 0.0299824240266779 no 183 0.0236687026281887 253 16001701
SGTC_1681 tripelennamine 100 µM 1.98146515459553 0.0300999086975118 no 184 0.0237695666680097 185 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2723 salbutamol 83.58 µM 1.97837022669525 0.0303023860345128 no 185 0.0239434779839276 112 9884233 β2-adrenoceptor agonist
SGTC_1970 st070122 35.8 µM 1.97808265783451 0.0303212566310411 no 186 0.0239596913163949 242 102928
SGTC_1721 st082152 9.2685 µM 1.96646161383142 0.0310920299795268 no 187 0.0246226561256699 216 5296051
SGTC_702 1488-0190 94 µM 1.9585366251722 0.0316269016993023 no 188 0.0250835388881275 191 949357
SGTC_227 fluconazole 33.516 µM 1.95609234564033 0.0317933967674852 no 189 0.0252271383433169 304 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1770 st043884 66.3 µM 1.95475024388621 0.0318851231790196 no 190 0.0253062782768513 214 670149
SGTC_116 0155-0182 31.788 µM 1.95460315265062 0.0318951894582971 no 191 0.0253149644634492 379 771486
SGTC_2320 7373003 200 µM 1.95166225766609 0.0320970029127541 no 192 0.0254891581863091 212 5415828
SGTC_95 0471-0001 561.058 µM 1.9489036049254 0.0322872674953736 no 193 0.0256534687473264 244 4015405
SGTC_543 3844-1095 191 µM 1.94042945197565 0.0328775598251425 no 194 0.0261637600870316 279 4230703
SGTC_2244 6635614 200 µM 1.94028214269814 0.0328878992317254 no 195 0.0261727051831677 130 836499
SGTC_1366 1683-0113 21.9 µM 1.93845402485943 0.0330164351045577 no 196 0.0262839273587038 204 708623
SGTC_1830 st055982 50.3 µM 1.93818357210676 0.0330354858762214 no 197 0.0263004151306058 247 455313 An antimicrobial agent.
SGTC_3249 9135183 49.47 µM 1.93438397133355 0.0333040897023835 no 198 0.0265329678568226 239 4902779
SGTC_343 4130-2827 29.8 µM 1.93415497041104 0.0333203356841721 no 199 0.0265470384680462 253 1118244
SGTC_1172 0370-0043 85 µM 1.92542712569129 0.0339443949878348 no 200 0.0270879723758549 215 376585
SGTC_47 0149-0135 24.25 µM 1.92250531560689 0.0341554461704634 no 201 0.0272711026927914 231 5239155
SGTC_14 0354-0009 295 µM 1.91563091307963 0.0346562622362891 no 202 0.027706045936915 247 1713507
SGTC_392 N-ethylmaleimide 8.33 µM 1.90816015250141 0.0352073466803897 no 203 0.0281852600359011 226 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2507 purpurin 79.67 µM 1.90461529652038 0.0354713385467346 no 204 0.0284150483657531 277 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2101 5377231 179.231 µM 1.90278830068454 0.0356080307743511 no 205 0.0285340872073578 203 2844213
SGTC_1070 indatraline 8.81 µM 1.89944707652204 0.0358591313759922 no 206 0.0287528594026774 266 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2943 9068529 45.32 µM 1.89709549472245 0.0360367264856271 no 207 0.0289076678635817 260 3270634
SGTC_2802 7925815 54.55 µM 1.88999696897183 0.0365771917043011 no 208 0.0293791827291496 296 1262923
SGTC_1446 4239-0190 62 µM 1.88761386531508 0.0367601157332558 no 209 0.0295389036578982 297 1340085
SGTC_2710 st078562 53.7235 µM 1.8849270510725 0.0369672487462183 no 210 0.0297198436769368 228 17250908
SGTC_3004 9076122 71.4286 µM 1.8750375414114 0.0377378888335934 no 211 0.0303937795222655 275 44782551
SGTC_3283 9109332 35.8195 µM 1.8749147546799 0.0377475387815599 no 212 0.0304022259419932 198 17027281
SGTC_3233 9132340 49.47 µM 1.87181391913538 0.0379919053756774 no 213 0.0306161759515278 230 17682950
SGTC_2183 6420625 130.508 µM 1.86667180168553 0.0383999821770427 no 214 0.0309737169397062 346 2897619
SGTC_2172 5754775 163.918 µM 1.86477963933193 0.0385510399864516 no 215 0.0311061491853907 269 2263357
SGTC_206 4546-0025 72.014 µM 1.86418725158502 0.0385984317469654 no 216 0.0311477065038574 331 6620745 YIL048W NEO1
SGTC_2253 7938677 135.83 µM 1.86334646800735 0.0386657769802417 no 217 0.0312067681869196 235 2301972
SGTC_2990 9074105 71.4286 µM 1.85936090088152 0.0389863172996488 no 218 0.0314879999826095 214 6502001
SGTC_1630 st005209 31.3 µM 1.85602883637476 0.0392559571266261 no 219 0.0317247239697141 308 3367314
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.85344943794216 0.0394657296699616 no 220 0.0319089834521584 251 4213774
SGTC_1238 0333-0287 48.8 µM 1.8528568020452 0.0395140550644019 no 221 0.0319514430705186 259 7226
SGTC_2739 tacrine 100.86 µM 1.85107790951331 0.0396594006910732 no 222 0.0320791727970795 234 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1771 st048882 4.1505 µM 1.85008934314074 0.0397403599230067 no 223 0.0321503368254762 267 4580403
SGTC_1014 4130-3005 69.3 µM 1.83889517699079 0.0406665208265196 no 224 0.0329653026687154 306 743608
SGTC_1802 st050112 57.9 µM 1.82533510154045 0.04181180824868 no 225 0.0339752381277393 259 4662563
SGTC_1645 Cervolide 78 µM 1.82511034682295 0.0418310088976855 no 226 0.0339921895567623 224 23173 A fragrance.
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.82104436945065 0.0421795972532797 no 227 0.0343000562790829 245 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2070 5230947 200 µM 1.82080939008198 0.04219981437055 no 228 0.034317918212771 262 2835538
SGTC_120 rhodamine 6G 52.259 µM 1.81941055608387 0.042320329359754 no 229 0.0344244087158703 367 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2480 5767542 37.17 µM 1.81931430349864 0.0423286321223751 no 230 0.0344317462106563 235 2867358
SGTC_1400 3771-8998 51.5 µM 1.81314282246757 0.0428637419575278 no 231 0.0349048979522364 214 670767
SGTC_1027 k015-0025 8.67 µM 1.81098841130193 0.0430518265963322 no 232 0.0350713227816831 295 3598955
SGTC_3139 9095020 49.47 µM 1.80620309323892 0.043471980409291 no 233 0.0354433109724854 175 25236292
SGTC_1575 cyproterone acetate 48 µM 1.8029119538828 0.0437628608274013 no 234 0.0357010216755654 283 9880 An androgen receptor antagonist and liver toxin.
SGTC_2259 7964009 200 µM 1.79912535710305 0.0440994716906151 no 235 0.0359994266850169 260 313134
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.79863963225905 0.0441428010318654 no 236 0.0360378519303027 166 279621
SGTC_114 0364-0001 490.298 µM 1.79799716880615 0.0442001650382522 no 237 0.0360887282153766 324 4003655
SGTC_300 r073-0011 5.04 µM 1.79368193149877 0.0445870210672554 no 238 0.0364319754355774 322 2735780
SGTC_2938 9059746 27.26 µM 1.79212209959246 0.044727527520299 no 239 0.0365567047886739 286 6471769
SGTC_2464 5717415 7.67 µM 1.78610081973892 0.0452732601351984 no 240 0.0370414677345372 300 5285744
SGTC_2979 9012552 45.46 µM 1.77837620727081 0.0459812026468636 no 241 0.0376710438452598 221 17100905
SGTC_207 4185-0010 4.486 µM 1.77687541858635 0.0461197728386041 no 242 0.0377943698066482 380 3761753
SGTC_309 k408-0051 1.48 µM 1.77225340842705 0.0465486385126223 no 243 0.0381762507677006 381 3640463
SGTC_1436 4092-1007 8.32 µM 1.76776139594345 0.0469685030593439 no 244 0.0385504005681181 279 2881121
SGTC_3334 9142812 21.919 µM 1.7664721353291 0.0470895684377661 no 245 0.0386583361891657 292 45283678
SGTC_2140 5586273 200 µM 1.76275634987941 0.0474398917433864 no 246 0.0389707961487564 233 854421
SGTC_2145 5634607 200 µM 1.76253025736064 0.047461274902724 no 247 0.038989874419957 237 308662
SGTC_1547 harmine 94.2 µM 1.7618764333939 0.0475231550894774 no 248 0.0390450885743337 377 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2328 6201408 200 µM 1.75864885502751 0.0478295719997366 no 249 0.039318584710014 294 2890418
SGTC_2150 5556613 200 µM 1.75706789813882 0.0479802395588026 no 250 0.0394531183416139 320 743190
SGTC_2484 5809818 12.04 µM 1.752826243643 0.0483863529855822 no 251 0.0398159184795808 292 2870548
SGTC_2318 6029776 164 µM 1.75231543681717 0.0484354446606533 no 252 0.0398597915499837 325 818325
SGTC_3333 9141820 12.094 µM 1.75022613860564 0.0486366538487001 no 253 0.0400396500914903 253 1939433
SGTC_911 3456-4043 236 µM 1.74760447340175 0.0488900771538978 no 254 0.0402662701018004 340 914281
SGTC_1467 k284-1082 293 µM 1.74258371364004 0.0493783535228004 no 255 0.0407031784596489 301 3334705
SGTC_2572 astragaloside iv 100 µM 1.74011742404067 0.0496196256688275 no 256 0.0409192006625871 318 45006101 An anti-inflammatory agent.
SGTC_433 pimozide 108 µM 1.73656354945378 0.0499689475173059 no 257 0.0412321190542611 219 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_269 exalamide 29 µM 1.73512046971078 0.0501113511660069 no 258 0.0413597346669038 262 3316 A derivative of salicylamide.
SGTC_136 0097-0015 404.482 µM 1.73299107296043 0.050322071584394 no 259 0.0415486277467173 340 4861337
SGTC_2071 5230951 39.92 µM 1.73073249351176 0.0505463467414516 no 260 0.0417497434952666 319 1799272
SGTC_44 0929-0055 61.211 µM 1.72697311223267 0.0509214153207107 no 261 0.0420862462382063 287 1379590
SGTC_1755 st041960 45.185 µM 1.72679538383513 0.0509392017521639 no 262 0.0421022089165635 301 2257073
SGTC_2178 5812956 200 µM 1.71611493463799 0.0520171724989882 no 263 0.0430705041533395 287 5403383
SGTC_2734 clemastine 41.6 µM 1.71143908858253 0.0524947709544058 no 264 0.0435000432683903 155 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2119 5528445 120.635 µM 1.71119718667553 0.0525195735891411 no 265 0.0435223589331713 308 791935
SGTC_2662 daunorubicin 22.37 µM 1.71105499812708 0.0525341567751137 no 266 0.0435354802638125 274 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3138 9097216 49.47 µM 1.70327355111518 0.0533371525832848 no 267 0.044258443923447 308 25237486
SGTC_2460 5552655 174.22 µM 1.70308239061793 0.0533570008744797 no 268 0.0442763254339169 334 5401989
SGTC_362 0310-0100 9.03 µM 1.69831672736502 0.0538537167588483 no 269 0.0447239996455245 343 790235
SGTC_1189 1431-2119 7.28 µM 1.69238342936326 0.0544772419103598 no 270 0.0452864448779019 376 3107275
SGTC_3347 9188721 44.724 µM 1.6911882586157 0.0546035296099198 no 271 0.0454004263883066 284 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1564 D-Arginine 115 µM 1.68824427727079 0.0549155928286978 no 272 0.0456821734564091 344 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_864 0469-0573 172 µM 1.68541134513688 0.0552172138683042 no 273 0.0459546181394682 318 689425
SGTC_2026 5148700 152 µM 1.68533072121915 0.0552258169729362 no 274 0.0459623908508533 317 79838
SGTC_1307 1187-1599 12.2 µM 1.68367758747227 0.0554024507811477 no 275 0.0461219975341102 311 1538471
SGTC_1618 st003135 44.5 µM 1.67869414481402 0.055937621170539 no 276 0.046605833834155 287 1270615
SGTC_956 1185-0240 191 µM 1.67623158211976 0.056203576252675 no 277 0.0468464201503568 328 1416193
SGTC_1740 st038286 13.222 µM 1.67543149872189 0.0562901989685616 no 278 0.0469248003867432 354 716786
SGTC_1345 1488-0192 31.4 µM 1.66959731046339 0.0569250353885379 no 279 0.0474995314516136 341 658348
SGTC_1922 5578187 25 µM 1.66886292173729 0.0570053444688611 no 280 0.0475722746497087 346 1350412
SGTC_1407 3909-7909 12.3 µM 1.66737551694343 0.057168272896346 no 281 0.0477198795184098 352 4411780
SGTC_768 0384-0033 77.3 µM 1.66328415952117 0.0576183260034675 no 282 0.0481277840070916 420 3965305 YMR134W ERG29
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.65783267302495 0.0582223189365351 no 283 0.0486756222784603 345 115019
SGTC_1744 st037937 38.9 µM 1.65682276092168 0.0583347554500814 no 284 0.0487776569364604 333 1016152
SGTC_2299 7976368 114.88 µM 1.65509071410457 0.0585279863544112 no 285 0.0489530491077951 322 2979718
SGTC_2532 xanthone 78.9 µM 1.65471660296675 0.0585697889304293 no 286 0.0489909987976231 336 7020 An insecticide.
SGTC_1082 camptothecin 424.86 nM 1.65446689878758 0.0585977035152364 no 287 0.0490163417701611 343 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.64490451146162 0.0596745681590779 no 288 0.0499947522130794 440 551469
SGTC_3008 9078912 71.4286 µM 1.64351289104024 0.059832569339908 no 289 0.0501384302002769 316 16648731
SGTC_2082 5219693 150 µM 1.64345437892961 0.0598392198340502 no 290 0.050144478492712 357 2834649
SGTC_2759 disulfiram 3.38 µM 1.64323480209661 0.0598641821294683 no 291 0.0501671809451674 352 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1240 0356-0016 42.1 µM 1.64164194727359 0.0600455079524313 no 292 0.0503321145355526 353 4305613
SGTC_679 0422-0091 41.4 µM 1.64145723334968 0.060066563030831 no 293 0.0503512688351314 390 627384 YHR062C RPP1
SGTC_838 0109-0203 71.4 µM 1.64128336864815 0.060086386714743 no 294 0.0503693034084534 346 759422
SGTC_1258 0671-0043 57.1 µM 1.63144386152337 0.06121663739591 no 295 0.0513983481278566 375 4298767
SGTC_1643 st009866 20.2 µM 1.63102326603182 0.0612653183658792 no 296 0.0514427051731743 297 3156273 YOR207C RET1
SGTC_3095 9117207 49.47 µM 1.62739341287184 0.0616867062451214 no 297 0.0518267848193433 269 17015229
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.62456273966794 0.0620168854200981 no 298 0.0521278809265801 319 688803
SGTC_94 0334-0113 514.748 µM 1.62345546591615 0.0621464161254437 no 299 0.0522460380107782 360 6795178
SGTC_2159 5658611 73.75 µM 1.62329861549811 0.0621647817991202 no 300 0.0522627926897388 303 793844
SGTC_2617 dihydrotanshinone i 20.83 µM 1.6203167483984 0.062514735667702 no 301 0.0525821264796194 404 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_719 2810-4230 27.3 µM 1.62022769708859 0.0625252103579549 no 302 0.0525916869138518 283 721079
SGTC_2056 5235370 200 µM 1.61556179825412 0.0630759546682898 no 303 0.0530945444983336 385 5511916
SGTC_2552 juarezic acid 87.02 µM 1.61182436736849 0.0635198255951266 no 304 0.0535000820369737 430 1549512
SGTC_1859 st055998 20 µM 1.61027374891748 0.0637046946328044 no 305 0.0536690537333362 378 676301
SGTC_2427 5545055 42.75 µM 1.60978311363166 0.0637632766285821 no 306 0.0537226064625367 388 5372858
SGTC_1851 st056236 18.9 µM 1.60976020750233 0.0637660126506364 no 307 0.0537251076950056 354 5393171
SGTC_3163 9099914 49.47 µM 1.60964441309906 0.0637798451080264 no 308 0.0537377532647602 248 16268368
SGTC_254 nsc-64875 3.808 µM 1.60936321155736 0.0638134463301782 no 309 0.0537684722800556 350 56993
SGTC_237 nikkomycin 200 µM 1.60768890338427 0.0640137972295578 no 310 0.0539516650418073 374 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_776 4476-4378 112 µM 1.6068491769464 0.0641144644850019 no 311 0.0540437287482894 323 2892008
SGTC_157 1348-1695 65.819 µM 1.60401680681777 0.0644549196963437 no 312 0.054355174007455 462 5380510
SGTC_1759 st043059 70 µM 1.60352527613714 0.0645141452011462 no 313 0.0544093666452922 413 669426
SGTC_456 gingerol 170 µM 1.59210720418109 0.0659018620531727 no 314 0.0556803093265417 374 442793 A herb.
SGTC_2157 5649910 96.377 µM 1.58358673115019 0.0669524015086856 no 315 0.0566438977053201 398 2858091
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.58094179409503 0.0672811325936339 no 316 0.0569456735039476 382 390807
SGTC_970 1315-0089 19.5 µM 1.57920058643808 0.0674982221151417 no 317 0.0571450277513549 351 6811083 YLR033W RSC58
SGTC_395 anisomycin 6.25 µM 1.57820722308144 0.0676223145071541 no 318 0.0572590057042327 315 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_769 0302-0231 76 µM 1.57563002947158 0.0679450831308263 no 319 0.0575555456812384 479 571869 YER009W NTF2
SGTC_3237 9133362 49.47 µM 1.57298082868866 0.0682781085792919 no 320 0.0578616287064151 366 43845137
SGTC_3309 9129340 25.759 µM 1.57023401039482 0.0686247340245848 no 321 0.0581803399578992 396 17158987
SGTC_614 0462-0418 107 µM 1.56818294092765 0.0688844456853551 no 322 0.0584192222025951 351 5188303
SGTC_2540 epiandrosterone 100 µM 1.56725503285607 0.0690021884242757 no 323 0.0585275457735392 525 441302 A steroid.
SGTC_1861 st057647 17.4 µM 1.56564687159021 0.0692066161401619 no 324 0.058715655240607 382 688668
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.56042457956158 0.069873687088693 no 325 0.0593297900340639 370 2724278 An inhibitor of dopamine biosynthesis.
SGTC_223 busulfan 5 mM 1.560349195234 0.0698833524285478 no 326 0.0593386918673645 298 2478 A DNA alkylator.
SGTC_69 0096-0274 206.684 µM 1.56010347514771 0.0699148643709342 no 327 0.059367715237998 459 6741392
SGTC_2956 9076196 2.52 µM 1.55976549865262 0.0699582254365572 no 328 0.0594076537081595 397 16423868
SGTC_3235 9132602 49.47 µM 1.55325520892634 0.0707975141908567 no 329 0.0601810882013525 429 4912240
SGTC_1733 st037357 54.9 µM 1.55098368527411 0.0710921663692979 no 330 0.0604527968855713 437 1272339 YGL099W LSG1
SGTC_414 piperonyl butoxide 100 µM 1.54876984468577 0.0713802414158917 no 331 0.0607185285100228 355 5794 A potent inhibitor of cytochrome P450.
SGTC_62 0180-0423 3.232 µM 1.54660653474971 0.0716626058803787 no 332 0.0609790765029682 379 30102 YGL099W LSG1
SGTC_2428 5615643 7.78 µM 1.54585946240487 0.0717603157600134 no 333 0.0610692562875121 395 2253075
SGTC_524 r073-0010 27.8 µM 1.54286284624431 0.0721532715929026 no 334 0.0614320285575335 389 2772106
SGTC_2321 7390090 138.78 µM 1.53613340101449 0.0730417339825493 no 335 0.0622528329307754 354 649046
SGTC_773 4358-1457 44.6 µM 1.533768216409 0.0733559807326486 no 336 0.0625433423922744 464 1186886
SGTC_1336 1486-0901 104 µM 1.52682749874568 0.0742841195004922 no 337 0.0634019558687274 397 5006114
SGTC_131 0141-0277 33.849 µM 1.5240566632419 0.0746571407129725 no 338 0.063747278554051 427 1547771
SGTC_3094 9117742 49.47 µM 1.52359842151457 0.0747189686050321 no 339 0.0638045288677991 442 17149698
SGTC_981 1488-1094 54.9 µM 1.51715476325002 0.0755925166267843 no 340 0.0646138072430139 359 3449522
SGTC_1747 st037496 66.6 µM 1.51506864535986 0.0758769866064163 no 341 0.0648775105149817 456 723305
SGTC_183 3914-0051 30.55 µM 1.51214526328426 0.076276999454688 no 342 0.0652484561036227 406 1596232
SGTC_2880 9042983 58.44 µM 1.50574087446793 0.0771589326047298 no 343 0.0660668533445744 425 6464714
SGTC_1050 3232-1156 69.3 µM 1.50473599798926 0.0772980121761897 no 344 0.0661959821052409 434 700529
SGTC_2112 5488546 200 µM 1.50409993988997 0.0773861439417647 no 345 0.0662778178958321 424 600757
SGTC_295 k015-0027 31 µM 1.50325987728147 0.0775026593683074 no 346 0.0663860211339505 388 3887424
SGTC_2240 6690706 185.951 µM 1.50068348809761 0.0778608315277957 no 347 0.0667187229038618 354 805876
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.4987127109564 0.0781356578226951 no 348 0.0669740888772314 452 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2061 5245884 80.95 µM 1.49729528947499 0.0783337727571308 no 349 0.0671582200170891 435 573863
SGTC_3236 9132701 49.47 µM 1.49517796811427 0.0786304228042112 no 350 0.0674340009235145 403 24282524
SGTC_2284 7945075 39.21 µM 1.49248046907505 0.0790095917817752 no 351 0.0677866168063909 473 1245402
SGTC_1332 1480-0653 17.5 µM 1.49061885994322 0.079272071976151 no 352 0.0680307949266745 441 5749438
SGTC_507 nimesulide 162 µM 1.49004028985621 0.0793537825964872 no 353 0.0681068212815781 429 4495 A COX2 inhibitor.
SGTC_2766 oltipraz 83.91 µM 1.48609527535706 0.0799126315415761 no 354 0.0686269609143211 419 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_485 niflumic acid 177 µM 1.48193632426914 0.0805050039605654 no 355 0.0691786193425921 388 4488 A COX2 inhibitor.
SGTC_2825 7998094 58.44 µM 1.48138241181455 0.0805841491158351 no 356 0.0692523494250721 416 2987815
SGTC_522 1273-0010 11.6 µM 1.48138147459156 0.0805842830796695 no 357 0.0692524742280694 419 5705015
SGTC_2039 Aminomethylbenzodioxan 200 µM 1.48099024421167 0.0806402190652431 no 358 0.0693045865951569 367 15053
SGTC_1768 st044301 37.178 µM 1.48051482400696 0.080708231515329 no 359 0.0693679538028531 437 3931349
SGTC_2655 perillic acid 100 µM 1.47877523372091 0.0809574623028744 no 360 0.0696001985610389 367 5702197 An apoptosis inducer.
SGTC_3030 9087619 49.47 µM 1.47662091864945 0.0812669153103098 no 361 0.069888640557395 407 25236973
SGTC_1838 st055369 84.5 µM 1.47600241383637 0.0813559240768947 no 362 0.0699716221154769 380 676036
SGTC_2692 st077426 47.7 µM 1.47390939117039 0.0816576755893169 no 363 0.0702529944358931 452 25238571
SGTC_57 miconazole 162.5 nM 1.46957374391607 0.0822854299073678 no 364 0.0708386178507768 410 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1649 st011737 51.3 µM 1.46528919221745 0.0829093497624889 no 365 0.0714210169770796 427 1761035
SGTC_1680 diphenhydramine 100 µM 1.46404519530306 0.0830911665746945 no 366 0.0715908000090367 437 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2924 9010168 62.78 µM 1.4636829720577 0.0831441637675031 no 367 0.071640295083901 468 2993929
SGTC_3262 9137218 49.47 µM 1.45886088545408 0.0838521108457314 no 368 0.0723017003486672 268 17650664
SGTC_1901 st060216 58.6 µM 1.45735041873915 0.0840747962068611 no 369 0.0725098379679926 445 688792
SGTC_558 k064-0027 21.3 µM 1.45645493103583 0.0842070258009309 no 370 0.0726334499265003 446 5088526
SGTC_3342 9147791 14.508 µM 1.45458535625571 0.0844835941851229 no 371 0.072892043723474 434 1838168
SGTC_1424 4048-1941 275 µM 1.44870367276896 0.0853581228817623 no 372 0.0737101771789258 460 X1424
SGTC_1792 st045773 43.6 µM 1.44609230394538 0.08574856562666 no 373 0.0740756570209467 443 2919270
SGTC_2314 7727897 200 µM 1.44581383536383 0.0857902800329602 no 374 0.07411471224205 430 900724
SGTC_393 acivicin 6.25 µM 1.44218851630014 0.0863347372858899 no 375 0.0746245996558667 408 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_305 1682-2595 20.8 µM 1.44197745799525 0.0863665138337766 no 376 0.0746543664719757 476 226033
SGTC_1061 3448-9325 110 µM 1.43218832486178 0.0878499750027315 no 377 0.0760449660538474 418 723482
SGTC_1988 st071872 53.4 µM 1.43198524292444 0.0878809503420091 no 378 0.0760740223362065 410 16414116
SGTC_1091 telmisartan 47.6 µM 1.4305577640953 0.0880989083156414 no 379 0.0762784997673296 463 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1984 st072354 53.1 µM 1.42880755775015 0.0883666923699372 no 380 0.0765297763652276 441 5762938
SGTC_3180 9109287 49.47 µM 1.42640720441961 0.0887349355579477 no 381 0.0768754176628752 409 18891271
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.42533762220618 0.0888993899630907 no 382 0.0770298149154133 437 229346 A bile salt which induces apoptosis.
SGTC_2765 myclobutanil 7.74 µM 1.42404720953963 0.0890981002105607 no 383 0.0772164032257844 475 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_73 0327-0325 16.231 µM 1.42145985514401 0.0894975216657775 no 384 0.0775915581640534 534 53298
SGTC_154 3389-1638 511.116 µM 1.42091437534601 0.0895818995300954 no 385 0.0776708266654677 405 5238686
SGTC_583 1488-1091 88.9 µM 1.41953755886745 0.0897951362657523 no 386 0.0778711774718347 562 4303273
SGTC_2544 sphondin 68.51 µM 1.41385699740384 0.0906789131798521 no 387 0.0787019471447781 430 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_3122 9126309 49.47 µM 1.41224931928771 0.0909302026037192 no 388 0.0789382816539387 428 17591206
SGTC_1931 st074438 57.1 µM 1.40904981787901 0.0914318397544462 no 389 0.0794102189140368 441 2787313
SGTC_964 1287-0107 19.4 µM 1.40885856106924 0.0914618909973279 no 390 0.0794384974365001 520 51516812 YPR165W RHO1
SGTC_139 0099-0334 718.624 µM 1.40822921580913 0.0915608286046881 no 391 0.0795316038946272 559 97690
SGTC_1459 k035-0031 35.7 µM 1.40654010918603 0.0918267603843887 no 392 0.079781901550225 426 3877128 YMR208W ERG12
SGTC_1308 1187-1617 41.4 µM 1.40242455194403 0.0924771053496405 no 393 0.0803942529901528 522 2882570
SGTC_2664 lyso-paf C-16 73.48 µM 1.39897262206375 0.0930252059067136 no 394 0.0809105965810911 491 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3222 9128301 49.47 µM 1.39233016213051 0.0940866511320816 no 395 0.0819112209478789 478 4911358
SGTC_121 0557-0495 61.343 µM 1.39035450948298 0.0944040720991773 no 396 0.0822106264797927 656 3104427
SGTC_540 1187-0821 17.3 µM 1.38774636860346 0.0948243210769082 no 397 0.0826071455391591 464 847520
SGTC_19 0279-0214 38.434 µM 1.38470134892139 0.0953167065067173 no 398 0.0830719032293509 595 3566274 YBR002C RER2
SGTC_3143 9086658 49.47 µM 1.38371471428971 0.0954766502620384 no 399 0.0832229131231928 563 25236626
SGTC_633 0437-0093 97.7 µM 1.38218561575692 0.0957249232471514 no 400 0.0834573577958898 466 2831118
SGTC_1196 1588-0294 184 µM 1.37822806755296 0.0963696977561503 no 401 0.0840664420257269 461 6144269
SGTC_2683 piperine 63.03 µM 1.37329866238162 0.0971772660879665 no 402 0.0848297591379612 467 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2018 5133068 143 µM 1.3724279234316 0.0973204309999394 no 403 0.0849651311865334 487 785362
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.37045460812234 0.0976454515901793 no 404 0.0852725178183723 539 688664
SGTC_2467 5474540 200 µM 1.36975518532088 0.0977608428768044 no 405 0.0853816678307314 499 5413519
SGTC_1752 st044819 83.042 µM 1.36924435895891 0.0978451825302746 no 406 0.0854614521029765 492 441209 YML126C ERG13
SGTC_1930 st074634 34.3 µM 1.36923368633849 0.0978469451949138 no 407 0.0854631196193854 518 684253 YOR116C RPO31
SGTC_951 1171-0579 82.7 µM 1.36740631140327 0.098149093370246 no 408 0.0857489925841193 592 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_765 1319-0117 244 µM 1.36417622922707 0.0986848437870678 no 409 0.0862560538333257 458 3487746 YGL099W LSG1
SGTC_872 0588-0139 234 µM 1.3604819438945 0.0993002085345553 no 410 0.0868387314634838 532 2047100
SGTC_2690 usnic acid 100 µM 1.36017798034832 0.0993509650072408 no 411 0.0868868044518757 578 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_950 1165-0508 94.1 µM 1.35733984174185 0.0998257989261618 no 412 0.0873366267256819 484 6148369
SGTC_1067 clotrimazole 1.36 µM 1.35695679640336 0.0998900109596525 no 413 0.0873974692557048 540 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2229 7354935 190 µM 1.35684736464851 0.0999083611561913 no 414 0.0874148570929124 429 318112
SGTC_2897 9048598 12.99 µM 1.35678731958448 0.0999184309315947 no 415 0.0874243988739958 485 6467404
SGTC_2391 6285546 200 µM 1.35338994505638 0.100489391056921 no 416 0.0879655439918707 529 846083
SGTC_1025 k007-0731 70 µM 1.3531168203936 0.100535395342862 no 417 0.0880091564323439 480 6256118
SGTC_1317 1273-0028 910 nM 1.35086334621841 0.100915550144467 no 418 0.088369605776555 503 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_325 2810-4341 181 µM 1.34641143509799 0.101669653410849 no 419 0.0890849325653013 494 774970
SGTC_1514 1189-1591 158 µM 1.34620599697458 0.101704551070313 no 420 0.08911804579114 568 767698 YMR146C TIF34
SGTC_2522 biochanin a 4.94 µM 1.3458738295231 0.101760994618766 no 421 0.0891716050648381 465 5280373 A possible chelator.
SGTC_89 0302-0250 142.109 µM 1.34498162538249 0.101912715272288 no 422 0.0893155842256257 555 4203518 YLR208W SEC13
SGTC_2555 cholic acid 100 µM 1.34411815825159 0.102059705854469 no 423 0.0894550905753528 513 6708657 Influences liver metabolism.
SGTC_3141 9094609 49.47 µM 1.34251669087507 0.102332736669498 no 424 0.0897142611150555 498 25236309 YDL196W YDL196W
SGTC_1877 wortmannin 25 µM 1.34193531507479 0.102431985517575 no 425 0.0898084849826171 573 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1440 4100-1550 40 µM 1.33807223050714 0.103093245328114 no 426 0.0904364460438219 461 742806
SGTC_2005 4024620 188 µM 1.33670400905367 0.103328191250093 no 427 0.0906596363956763 505 236743
SGTC_925 2064-1272 59.6 µM 1.33664222576761 0.103338809612519 no 428 0.0906697243980232 498 6815817
SGTC_2797 7859098 81.82 µM 1.33605172318778 0.103440336097441 no 429 0.0907661839591313 534 972681
SGTC_402 epigallocatechin gallate 10 µM 1.33383412917701 0.103822258678217 no 430 0.0911291115815777 557 65064 An antioxidant.
SGTC_482 fipronil 114 µM 1.33032641034502 0.104428458363881 no 431 0.0917053745742807 443 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1605 st000082 49.1 µM 1.32838151074204 0.104765676752804 no 432 0.0920260521714485 504 1114022
SGTC_1724 st037281 8.293 µM 1.32068498466543 0.106107881134145 no 433 0.0933032113693127 551 574124 YDL195W SEC31
SGTC_1620 st003704 16.5 µM 1.31749410799877 0.10666796876595 no 434 0.0938365273806378 533 2834414
SGTC_1429 4049-0205 9.46 µM 1.30724231719962 0.108481876810338 no 435 0.0955652138771716 567 22774478
SGTC_2390 9097792 176.6 µM 1.30720906564263 0.10848779608388 no 436 0.0955708587267788 499 4497149
SGTC_2752 diclazuril 33.15 µM 1.3038148379298 0.109093242274683 no 437 0.0961483611353582 720 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1965 Pectolinarigenin 58.4 µM 1.29682700905383 0.110347335179628 no 438 0.0973453576609901 548 5320438 An anti-inflammatory.
SGTC_1276 0871-0068 94.2 µM 1.29155333651321 0.11130061279741 no 439 0.0982559364442159 511 3414906
SGTC_1944 st076371 56.9 µM 1.28711332947013 0.112107755099569 no 440 0.0990273950612898 539 24208455
SGTC_361 000s-0510 1.45 µM 1.28291795874681 0.112874262019068 no 441 0.0997604101813232 578 660
SGTC_2814 7977482 42.97 µM 1.28247745076437 0.112954960671739 no 442 0.099837605077077 637 6456762
SGTC_92 0063-0024 660.874 µM 1.27744489199484 0.113879821598431 no 443 0.10072261218427 624 3594437
SGTC_385 1494-0393 12.4 µM 1.27212469592607 0.114863397331646 no 444 0.101664408951454 574 3090647
SGTC_3121 9125696 49.47 µM 1.27030011878481 0.115202105153088 no 445 0.101988872953272 522 1235365
SGTC_1103 duloxetine 36.1 µM 1.26675064806614 0.115863048813939 no 446 0.102622231850928 639 60835 A selective serotonin reuptake inhibitor.
SGTC_2193 5925765 200 µM 1.26550298323401 0.116096013688576 no 447 0.102845539831652 503 877370
SGTC_1723 st034307 2.5525 µM 1.26382607357386 0.116409650922056 no 448 0.103146230255344 555 867466
SGTC_2558 carylophyllene oxide 100 µM 1.25904303610217 0.117307536967543 no 449 0.104007393891768 620 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_3181 9108277 49.47 µM 1.25713797079629 0.117666523906282 no 450 0.104351839869899 547 17097298
SGTC_1653 st012112 65 µM 1.25614633471655 0.117853693362148 no 451 0.104531459765201 547 720429
SGTC_3049 9092223 49.47 µM 1.25588002586676 0.117903994523677 no 452 0.104579735721554 547 8623917
SGTC_687 k029-0044 34.9 µM 1.25256353162246 0.118531695960619 no 453 0.105182296867815 614 5829338
SGTC_2727 riluzole 51.77 µM 1.25093005212463 0.118841725538553 no 454 0.105479999227455 527 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2462 5162487 171.77 µM 1.2507461082295 0.118876673392951 no 455 0.105513561221917 590 2259986
SGTC_3036 9090181 49.47 µM 1.24350189555895 0.120258790934286 no 456 0.106841471438477 573 25236586
SGTC_1865 st057639 52.2 µM 1.24295551826939 0.120363491069268 no 457 0.1069421127081 583 688818
SGTC_2425 5628681 7.85 µM 1.24293429628316 0.12036755905017 no 458 0.10694602312181 674 5714958
SGTC_2795 7780010 54.55 µM 1.23396763091412 0.122095025657044 no 459 0.108607483087942 550 953673
SGTC_1935 st074532 41.6 µM 1.23261925427319 0.122356294475474 no 460 0.108858924952544 688 2829742
SGTC_579 4491-1009 110 µM 1.23180738944181 0.122513794969909 no 461 0.109010521167901 751 1271041
SGTC_2489 cantharidin 73.42 µM 1.23171676075639 0.12253138561405 no 462 0.109027453303672 605 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2902 5787006 60.46 µM 1.22677566996315 0.123493113648339 no 463 0.109953458875602 585 591003
SGTC_2227 7312221 64.1025 µM 1.22629281390607 0.123587378976807 no 464 0.110044252306781 558 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_694 1315-0438 43.2 µM 1.22247949415445 0.124333602934658 no 465 0.110763176886932 515 6793154
SGTC_1443 4112-3303 14 µM 1.22206424560203 0.124415052275552 no 466 0.110841666356553 617 704433
SGTC_1993 st073995 70.8 µM 1.22195811506847 0.12443587533995 no 467 0.110861733334779 616 3098394
SGTC_2763 lisinopril 49.32 µM 1.21949913748576 0.124919015055795 no 468 0.111327401517634 555 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1136 pergolide 1.05886 µM 1.21828682031761 0.125157692744047 no 469 0.111557498359481 701 47811 A dopamine receptor agonist.
SGTC_735 3076-0345 636 µM 1.21031193110976 0.12673570503819 no 470 0.113079610586802 669 2888990
SGTC_2995 9067767 71.4286 µM 1.20841032161744 0.127114018275476 no 471 0.113444735775422 544 11673567
SGTC_1478 0453-0656 35.7 µM 1.20810617842736 0.12717459846492 no 472 0.113503211755894 600 5258496
SGTC_2937 9044753 11.33 µM 1.20787200037902 0.127221256464993 no 473 0.11354825055696 642 6465530 YGL099W LSG1
SGTC_771 0250-0039 27.3 µM 1.20711047039605 0.127373067216521 no 474 0.113694801555564 617 3005115
SGTC_1692 fluoroquinolonic acid 71 µM 1.20630445914707 0.127533882494386 no 475 0.113850059474219 606 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.20424395507811 0.127945635629775 no 476 0.114247650743197 664 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1603 st002045 67.8 µM 1.20338382496138 0.128117789480357 no 477 0.114413912137786 623 5887985
SGTC_2231 micatex 6.853 µM 1.20254156440199 0.128286522610704 no 478 0.114576886235253 586 20737 An antifungal of unknown mechanism.
SGTC_2627 acetyl isogambogic acid 100 µM 1.20086346843983 0.128623161518451 no 479 0.114902083551081 588 6857789 A caspase activator and apoptosis inducer.
SGTC_1354 1498-1681 81 µM 1.19972511335263 0.128851872944229 no 480 0.115123058179555 663 5754243
SGTC_2201 6605497 169.863 µM 1.1995479404801 0.12888749480082 no 481 0.115157477687872 596 670741
SGTC_2315 7733312 200 µM 1.1951025696744 0.129783504267372 no 482 0.116023479071173 574 726316
SGTC_2025 5147754 141 µM 1.19495844973964 0.129812625107797 no 483 0.116051632195608 608 315777 YLR208W SEC13
SGTC_729 4092-0585 94.1 µM 1.18866131716927 0.131089441756812 no 484 0.117286484219871 589 2169061
SGTC_2784 7567673 72.73 µM 1.18689498185586 0.131449139546545 no 485 0.117634523479629 666 3471247
SGTC_1098 clofazimine 15.1 µM 1.18674770340612 0.131479162181209 no 486 0.117663576255347 686 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_3026 9090633 49.47 µM 1.18478615972512 0.131879473216877 no 487 0.118051003067262 628 25236842
SGTC_55 0767-0285 6.563 µM 1.18141605300787 0.132569204706917 no 488 0.118718741969157 678 3116166
SGTC_3271 9137798 49.47 µM 1.18025430384824 0.132807545165575 no 489 0.118949543386189 560 6498326
SGTC_1597 7-benzyloxygramine 47.5 µM 1.17964252819198 0.132933173492386 no 490 0.119071210407676 752 260807
SGTC_2911 7942208 15.64 µM 1.1789649120244 0.133072417660669 no 491 0.119206074000656 591 1243384
SGTC_1990 st072050 59.8 µM 1.17830218081366 0.133208700178274 no 492 0.119338079350365 650 17233948
SGTC_1697 st025554 27.742 µM 1.1780612784523 0.133258262576843 no 493 0.11938608876287 594 1269519
SGTC_1292 0kpi-0043 232 µM 1.17573534390316 0.133737444790209 no 494 0.119850325174388 615 3333905
SGTC_1072 oxiconazole 14.9 nM 1.1752722257066 0.133832996276598 no 495 0.119942911290999 669 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_642 0335-0876 158 µM 1.17194413082699 0.134521035758497 no 496 0.120609743780325 655 6812350
SGTC_1155 4088-0394 48.2 µM 1.17125670105162 0.134663454786633 no 497 0.12074780502466 644 2326248
SGTC_1062 mesoridazine 14.2 µM 1.17028775490225 0.13486437294889 no 498 0.120942593984124 656 4078 A neuroleptic.
SGTC_2884 9058502 51.95 µM 1.168775821981 0.13517829407486 no 499 0.121246982041301 648 6471554
SGTC_1826 st055655 41.6 µM 1.16695720440837 0.135556555100097 no 500 0.121613826278659 664 676168
SGTC_13 0199-0087 65 µM 1.16539356645174 0.135882361272401 no 501 0.121929860150576 665 4589825
SGTC_198 3454-2873 16.191 µM 1.16075433623119 0.136852164413506 no 502 0.122870908957847 651 710957
SGTC_315 k915-0449 187 µM 1.1584872928052 0.137327792891319 no 503 0.123332617176366 748 20970215 YNL149C PGA2
SGTC_2570 licareol 100 µM 1.1569303823303 0.137655087707684 no 504 0.123650402253621 648 443158
SGTC_829 1635-0120 117 µM 1.1567678217283 0.137689291981636 no 505 0.123683615952655 690 285054
SGTC_999 SEC7.066 22.7 µM 1.15579083847796 0.137894980587631 no 506 0.123883360651134 701 740511 YDR170C SEC7
SGTC_905 2-aminofluorene 215 µM 1.15567688122477 0.137918986156187 no 507 0.123906673962382 710 1539 An established DNA mutagen. YPR165W RHO1
SGTC_3009 9080819 71.4286 µM 1.15560415390664 0.137934307957875 no 508 0.123921554081626 654 17027216
SGTC_1696 st025591 34.7925 µM 1.14820880820315 0.139498383871426 no 509 0.125441186969421 678 2787147
SGTC_2118 5526350 200 µM 1.14740497102877 0.139669115099893 no 510 0.125607143829685 675 743594
SGTC_1803 st050068 52.4 µM 1.14605614677877 0.139955918119621 no 511 0.125885960527643 831 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3268 9137683 49.47 µM 1.1443395541459 0.140321498835326 no 512 0.12624142276667 636 1953228
SGTC_252 miconazole 1.30953 nM 1.14164608391228 0.140896430087369 no 513 0.126800580138911 646 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_466 geldanamycin 89.2 µM 1.13872245752623 0.141522295335323 no 514 0.127409466423709 539 5288382 HSP90 inhibitor.
SGTC_639 0833-0042 114 µM 1.13780810636266 0.141718418015683 no 515 0.127600309643835 714 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_3032 9089427 49.47 µM 1.13559485147092 0.142193909346113 no 516 0.128063082301357 632 17173707
SGTC_119 0121-0043 24.815 µM 1.13516861498814 0.142285604990269 no 517 0.128152338417368 837 1092378
SGTC_1201 1889-3372 45.9 µM 1.13462287638461 0.142403067349611 no 518 0.128266681955186 652 5392199
SGTC_2453 5731132 22.18 µM 1.12998887021947 0.143403113354077 no 519 0.129240457138714 727 1362040
SGTC_2887 9044784 58.44 µM 1.12966955826962 0.143472196966991 no 520 0.129307744536543 724 6465546
SGTC_3028 9087778 49.47 µM 1.12830973543353 0.143766648196707 no 521 0.129594566698592 658 17217395
SGTC_2418 pentamidine 31.67 µM 1.12156700376164 0.145232716222425 no 522 0.131023293840595 641 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.11872670389723 0.145853281679367 no 523 0.131628374624956 641 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1040 k898-0338 155 µM 1.10917447065659 0.147953369151935 no 524 0.133677461775371 760 20969351
SGTC_417 st075190 100 µM 1.10903428391598 0.147984339588142 no 525 0.133707696183033 719 222757
SGTC_2449 5812982 45.77 µM 1.1085078690854 0.148100675324064 no 526 0.133821271292175 655 776185
SGTC_1153 4055-0057 267 µM 1.10845085596642 0.148113278685265 no 527 0.133833575971429 717 882706
SGTC_3022 9087993 49.47 µM 1.10618982808223 0.148613681801819 no 528 0.134322182318919 677 17173644
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.10535261222196 0.148799258020974 no 529 0.134503414397574 715 688798
SGTC_1678 st019265 80.2 µM 1.10405420834396 0.149087366808243 no 530 0.134784811732222 728 5367020
SGTC_3247 9135149 49.47 µM 1.10319966421524 0.149277188704024 no 531 0.134970233565657 641 8934436 YOR116C RPO31
SGTC_2971 9092186 9.93 µM 1.1017555394627 0.149598342168351 no 532 0.135283982082639 639 25236400
SGTC_698 k064-0052 127 µM 1.09801335399717 0.150432696595304 no 533 0.136099329058522 684 5088751
SGTC_1353 1498-1206 8.11 µM 1.09619087214134 0.150840156017495 no 534 0.136497626664635 766 6756808
SGTC_408 cantharidin 100 µM 1.09616058230117 0.150846934236942 no 535 0.136504253141053 734 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_754 3474-0146 171 µM 1.09398140711299 0.151335119167579 no 536 0.136981566396151 659 24762078
SGTC_2709 st078560 56 µM 1.09126150042388 0.151945912895981 no 537 0.137578916606948 731 17250903
SGTC_2837 9008476 45.46 µM 1.09021612835509 0.152181101107527 no 538 0.137808975203143 713 2992805
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.08805216232279 0.152668718698008 no 539 0.138286040252297 855 688664
SGTC_1125 tnp00248 1.32998 µM 1.08790252707544 0.152702475047607 no 540 0.138319070203568 847 24207736
SGTC_3083 9117465 49.47 µM 1.08418549697809 0.153542592149397 no 541 0.139141280370225 697 16420915
SGTC_2400 5203494 178.7 µM 1.08009428893708 0.154470812421452 no 542 0.140050097395949 668 6777674
SGTC_169 k015-0017 16.025 µM 1.07990158036395 0.154514625759562 no 543 0.140093004729715 649 1840002
SGTC_349 k015-0014 24 µM 1.07748597612175 0.155064523238937 no 544 0.14063160630845 675 2196908
SGTC_2964 9083345 53.42 µM 1.0769619451873 0.155183986024567 no 545 0.14074863351656 662 17741579
SGTC_1447 4239-0816 81.9 µM 1.07482347707239 0.155672120064539 no 546 0.141226883680645 689 1341554
SGTC_1028 k015-0029 4.8 µM 1.07278795956663 0.156137693926602 no 547 0.14168313212762 729 4588309
SGTC_2020 4017018 200 µM 1.07081934952353 0.156588836224106 no 548 0.142125332435513 721 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_3251 9135047 49.47 µM 1.06979579567221 0.156823740699124 no 549 0.142355617589685 703 17682963
SGTC_248 streptozotocin 5.23457 mM 1.06644228577172 0.157594991121659 no 550 0.143111877563713 774 5300 DNA alkylating agent.
SGTC_2091 4-phenylthiadiazole 200 µM 1.06398986341933 0.158160581677672 no 551 0.143666645774394 756 270010
SGTC_2228 7354201 200 µM 1.06350773923248 0.158271928197574 no 552 0.143775878689891 739 753451
SGTC_843 0310-0051 143 µM 1.06184947573373 0.158655296557394 no 553 0.144152012447683 739 2065037
SGTC_1078 idebenone 36.1 µM 1.0610067490448 0.158850356847354 no 554 0.144343417015623 779 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1530 rhein 70.4 µM 1.06042225973503 0.158985736940265 no 555 0.144476269892877 794 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_807 1315-0151 48 µM 1.05816498052219 0.159509280141124 no 556 0.144990116856398 833 4011080
SGTC_3053 9095903 49.47 µM 1.05754700891357 0.159652806244883 no 557 0.145131006136099 756 17174018
SGTC_1441 4106-0040 13 µM 1.05707129322287 0.159763350457064 no 558 0.145239525707118 750 2904180
SGTC_2236 dapsone 200 µM 1.05563256486502 0.160097978961428 no 559 0.145568058511934 783 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2307 7538926 6.34 µM 1.05357284359601 0.160577838964833 no 560 0.146039263868908 751 96582
SGTC_1953 st076800 12.1 µM 1.05272434291188 0.160775789891214 no 561 0.146233674267498 749 297591
SGTC_1087 pterostilbene 9.05 µM 1.0496495777666 0.1614944513429 no 562 0.14693962700921 779 5281727 Similar to reservatol, lowers cholesterol.
SGTC_533 1222-0222 6.71 µM 1.04903186970927 0.161639079835558 no 563 0.147081725361249 809 3982874
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.04386747052599 0.162851560796584 no 564 0.14827335508692 799 6708561
SGTC_150 3970-0969 77.2 µM 1.04278979116569 0.163105318801259 no 565 0.148522830264831 810 6615640
SGTC_1519 esterone 74 µM 1.04219769416826 0.163244847475817 no 566 0.148660015944573 755 698 A steroid.
SGTC_517 1365-0151 113 µM 1.04134103412196 0.16344685812383 no 567 0.148858649346916 749 768657
SGTC_1876 myriocin 605 nM 1.04095481181197 0.163537987026316 no 568 0.148948260528337 773 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1207 2099-0101 141 µM 1.03627299722135 0.164645281595651 no 569 0.150037399974165 812 5837381
SGTC_2678 equilin 100 µM 1.03444313475255 0.165079379134799 no 570 0.150464523988938 792 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.03260311285932 0.16551663323121 no 571 0.150894835418664 847 368090
SGTC_3199 9111318 49.47 µM 1.0318581011481 0.165693887160007 no 572 0.15106929819335 779 8548020
SGTC_2731 amoxapine 43.43 µM 1.02910794289823 0.166349269907711 no 573 0.151714477060249 686 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2786 7743617 45.45 µM 1.02682120849482 0.166895488214681 no 574 0.152252330415329 687 583674
SGTC_796 1234-0020 70.7 µM 1.02291655052306 0.167830841122858 no 575 0.153173651737919 737 46495034
SGTC_140 0062-0056 502.533 µM 1.01917700711553 0.168729798816149 no 576 0.154059470195729 832 3758964
SGTC_1863 st057641 20.1 µM 1.01854053092303 0.168883110433702 no 577 0.154210574731227 827 3921635
SGTC_135 0933-0004 26.348 µM 1.01774170424555 0.169075654937812 no 578 0.15440036123918 731 21230617 YGL099W LSG1
SGTC_2224 6650123 117.647 µM 1.01617298395816 0.169454180172505 no 579 0.154773509496293 750 2908370
SGTC_2826 7992541 19.48 µM 1.01588480509692 0.169523775532023 no 580 0.154842122731077 753 2985066
SGTC_1351 1496-0003 46.5 µM 1.01525610155638 0.169675671435251 no 581 0.154991882073431 816 3891978
SGTC_894 0960-0238 55.9 µM 1.01514142352159 0.169703387265368 no 582 0.155019209086631 815 6741907 YDL195W SEC31
SGTC_580 1123-0028 41 µM 1.01409002299723 0.169957629142503 no 583 0.155269899138338 873 1677248 YPR107C YTH1
SGTC_336 4111-0029 111 µM 1.01134017181463 0.170623731519551 no 584 0.155926822665293 719 3131175
SGTC_1996 st072960 66.8 µM 1.00887134568091 0.171223182417207 no 585 0.156518169506592 831 1719405
SGTC_553 k007-0256 45.7 µM 1.00723733011192 0.171620674249926 no 586 0.156910368951347 795 6287000
SGTC_778 3456-2434 196 µM 1.00385623754074 0.172445031688366 no 587 0.157723956456403 896 5539063
SGTC_2917 7979103 53.79 µM 1.00159147880792 0.172998621426727 no 588 0.158270469083424 852 2980565
SGTC_2109 5483026 200 µM 1.0009614934219 0.173152813917151 no 589 0.158422712518811 813 759335
SGTC_1818 st052136 56.3 µM 1.00086734607285 0.17317586452937 no 590 0.158445472589773 760 674169
SGTC_547 1120-0019 610 nM 0.999583354228133 0.173490426352072 no 591 0.158756091013039 788 3676939
SGTC_2028 5153890 36.43 µM 0.998907624840418 0.173656117495151 no 592 0.158919721110074 778 2830968 YPR165W RHO1
SGTC_514 4466-0038 2.65 nM 0.998334582626295 0.173796708259584 no 593 0.159058571746663 853 5722064
SGTC_711 k292-0785 179 µM 0.996326258508969 0.17429000383112 no 594 0.159545824682068 807 4146315
SGTC_777 1315-0167 517 µM 0.992465482770647 0.175240804986405 no 595 0.160485254671231 764 4221767
SGTC_1709 st033179 39.1045 µM 0.990445909074241 0.175739477403875 no 596 0.160978107689475 834 573381
SGTC_1691 st019933 84.6 µM 0.990024258607897 0.175843704515403 no 597 0.161081131012325 800 6176082
SGTC_1474 0330-0125 5.35 µM 0.989806423516695 0.175897566161961 no 598 0.161134372268598 819 X1474
SGTC_2147 5545932 89.7195 µM 0.988184600666504 0.176298904573449 no 599 0.161531124274307 794 797404
SGTC_3214 9129694 49.47 µM 0.98515414584294 0.177050376423154 no 600 0.162274180135079 779 17158655
SGTC_526 4469-0568 170 µM 0.985102756096747 0.177063137132614 no 601 0.162286799860463 791 2901964
SGTC_760 0568-0725 82.9 µM 0.983957604214234 0.177347643232413 no 602 0.162568179329788 877 3916171
SGTC_1337 1486-1011 40.3 µM 0.983009432643152 0.177583429069555 no 603 0.16280139811798 814 X1337
SGTC_2567 aureobasidin a 60 nM 0.982645522449696 0.177673976668991 no 604 0.162890965718856 788 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_230 MPP+ 141.667 µM 0.982032200640203 0.177826648409069 no 605 0.163041992385223 781 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2038 4100038 30.985 µM 0.981685636227482 0.177912953878526 no 606 0.163127371942451 823 3596803
SGTC_1775 st081588 35.1725 µM 0.980746446067678 0.178146974620193 no 607 0.163358896738356 849 1426443 YGL099W LSG1
SGTC_520 3584-0023 682 µM 0.980180858203001 0.178287997358317 no 608 0.163498425762555 765 1340790
SGTC_125 0133-0007 11.75 µM 0.977660839266978 0.178917189363756 no 609 0.164121048100896 933 26541
SGTC_632 0781-2353 4.65 µM 0.977393941141518 0.178983909560645 no 610 0.164187080703597 834 6811515 YHR007C ERG11
SGTC_1824 st053723 68.6 µM 0.971903677956206 0.180359858240589 no 611 0.165549234943338 836 675225
SGTC_2726 cimetidine 79.27 µM 0.968715634120683 0.18116187111078 no 612 0.166343544946864 783 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1041 0206-0046 107 µM 0.967953654997872 0.181353891678269 no 613 0.166533757972334 826 50494
SGTC_2238 6671620 73.2395 µM 0.967106894186041 0.181567426869917 no 614 0.166745299707625 801 729941
SGTC_1173 0443-0020 122 µM 0.966258520027225 0.181781526650481 no 615 0.166957418296597 823 5331295
SGTC_137 0438-0332 85.389 µM 0.962110829696589 0.182830529779572 no 616 0.167996967338154 907 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1399 3562-5772 25 µM 0.961275229641106 0.183042319954719 no 617 0.168206899579635 768 23847490
SGTC_737 1950-0117 57.9 µM 0.961164714239714 0.183070342510659 no 618 0.168234677582396 838 5393513
SGTC_611 3453-1652 23.7 µM 0.959982151140663 0.183370363630856 no 619 0.168532099069766 874 1560575
SGTC_1648 st011736 69.8 µM 0.959384003411867 0.183522232843092 no 620 0.168682665355316 828 2855514
SGTC_550 4123-0385 25.7 µM 0.959188823786497 0.18357180574723 no 621 0.168731814849011 829 5731123
SGTC_3099 9120367 49.47 µM 0.95853124517245 0.183738882960275 no 622 0.1688974718687 849 24824940
SGTC_2525 harmine 47.85 µM 0.954289801152597 0.184818821565386 no 623 0.169968484559034 811 5280953 A monoamine oxidase inhibitor
SGTC_3173 9105693 49.47 µM 0.95352957132958 0.18501280420181 no 624 0.170160910316945 888 17096658
SGTC_323 4013-0906 34.3 µM 0.952744968802898 0.185213138446341 no 625 0.170359651500041 878 2910086
SGTC_3280 9140961 49.47 µM 0.952664030747421 0.185233812196127 no 626 0.170380161706734 814 4901226
SGTC_3184 9108758 49.47 µM 0.950971025235072 0.18566657964432 no 627 0.170809542343342 850 902885
SGTC_1010 4112-3296 15.2 µM 0.950134333805868 0.185880686815195 no 628 0.171021999766225 895 704384
SGTC_1315 1237-0019 3.69 µM 0.949137977777039 0.186135851388158 no 629 0.171275220532173 891 825140
SGTC_1046 2001-0062 216 µM 0.949099464882914 0.186145718811209 no 630 0.171285013273112 826 739778
SGTC_2399 5884133 200 µM 0.946645474644573 0.186775126200852 no 631 0.171909731667522 819 722445
SGTC_1106 tegaserod maleate 11.7 µM 0.946068603640064 0.186923274955762 no 632 0.17205679808756 879 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1612 st002233 45.4 µM 0.943950844092401 0.18746776918231 no 633 0.172597384094616 847 1035021
SGTC_469 w7 172 µM 0.943362029412913 0.187619332499718 no 634 0.172747878999376 849 45115570 A P450 inhibitor.
SGTC_2815 7968870 71.43 µM 0.94253181622647 0.187833161369102 no 635 0.172960214915978 862 2977326 YHR190W ERG9
SGTC_584 0986-0246 15.4 µM 0.94112952512844 0.188194675668046 no 636 0.173319243364096 941 53315 YDR232W HEM1
SGTC_947 3447-0010 211 µM 0.936500358482988 0.189391132013614 no 637 0.174507814043075 849 748350
SGTC_2948 9070189 9.45 µM 0.934957532248093 0.189790929434997 no 638 0.174905092864751 793 6473636 YDL196W YDL196W
SGTC_1372 2752-0194 270 µM 0.934835513064666 0.189822570781044 no 639 0.174936537361581 807 823334
SGTC_488 nitrendipine 139 µM 0.933996360277705 0.190040263134577 no 640 0.175152885245898 908 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2280 7785178 200 µM 0.932495116975188 0.190430097096301 no 641 0.17554035452366 854 2954328
SGTC_97 0535-0701 19.132 µM 0.931718508087284 0.190631954876833 no 642 0.175741009474494 811 2832013 YGL099W LSG1
SGTC_518 1021-0119 62.6 µM 0.931188669314959 0.190769747002531 no 643 0.175877988981179 812 1097762
SGTC_390 dec-rvkr-cmk 16.7 µM 0.9311706480415 0.190774434766086 no 644 0.175882649219587 913 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_813 k007-0158 173 µM 0.930263554651454 0.191010482732494 no 645 0.176117321434786 954 6523916
SGTC_1889 st059080 5.18 µM 0.929464654103493 0.191218524552095 no 646 0.176324167382917 923 176925 Isolated from Daphnopsis sellowiana.
SGTC_908 3448-7491 47.7 µM 0.928249031333313 0.191535351447031 no 647 0.176639203009823 933 1203031
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.927534471035046 0.191721736775446 no 648 0.176824551410139 832 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2654 protoveratrine a 100 µM 0.925524692403617 0.192246561023601 no 649 0.177346522796742 880 5702278 A heart drug and vasodilator.
SGTC_1129 3453-1384 223 µM 0.924569928608377 0.192496191198227 no 650 0.177594830613479 906 1084452
SGTC_921 1561-0023 372 µM 0.923664285370077 0.192733161472019 no 651 0.177830566180919 892 24050882
SGTC_2646 retinol 96.75 µM 0.920756723232834 0.193495157051229 no 652 0.178588727028065 868 445354 A vitamin A analog and teratogen.
SGTC_2732 terfenadine 20 µM 0.919337489697815 0.193867767341401 no 653 0.178959537233348 867 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_3188 9110789 49.47 µM 0.918881259503957 0.193987640361399 no 654 0.179078841600803 873 849217
SGTC_978 1416-0512 87.4 µM 0.918566450516321 0.194070381741349 no 655 0.179161193438471 913 6814003
SGTC_1147 3809-1045 12.3 µM 0.918536629114094 0.194078220827837 no 656 0.179168995744482 862 325925
SGTC_307 1501-1223 22.3 µM 0.917783831136833 0.194276171070777 no 657 0.179366024416288 870 2830329
SGTC_257 daunorubicin 18.5 µM 0.915261550774715 0.194940307012646 no 658 0.180027169415892 896 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_706 4262-0057 46.9 µM 0.91426837984023 0.195202194972779 no 659 0.180287920637254 885 883298
SGTC_1167 k781-0610 148 µM 0.913939293697768 0.195289018410367 no 660 0.180374372529614 920 4525169
SGTC_2645 abamectin 100 µM 0.912256911121228 0.19573325116569 no 661 0.180816745629279 873 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1787 fluconazole 80 µM 0.909184046868308 0.196546221980326 no 662 0.18162649185037 890 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1212 0520-0165 585 µM 0.907310863889565 0.19704280190329 no 663 0.182121215395387 870 5403258
SGTC_994 3910-0338 138 µM 0.906663236228471 0.197214664185357 no 664 0.182292455149155 940 3479481
SGTC_1234 0326-0494 15.5 µM 0.903405483595365 0.198080555333606 no 665 0.183155365367033 909 1547813
SGTC_510 ag-490 170 µM 0.90315007193228 0.198148539132789 no 666 0.183223126088854 995 5328779
SGTC_1221 2958-7315 257 µM 0.901069083913796 0.198702967643632 no 667 0.183775794750475 865 4562705
SGTC_2403 6032726 181.2 µM 0.899056920490198 0.19923994807702 no 668 0.18431117138189 882 2881040
SGTC_235 0330-0087 5 mM 0.898723242361144 0.199329080235625 no 669 0.18440004689127 948 46494818 YHR062C RPP1
SGTC_3243 9134147 49.47 µM 0.89816622297442 0.199477924832778 no 670 0.184548468961426 962 24282180
SGTC_2796 7949634 45.45 µM 0.897259565918327 0.19972034130434 no 671 0.184790213492149 850 2971588
SGTC_1779 st039427 55 µM 0.893675186712068 0.200680444932524 no 672 0.185747852629368 1012 1124498
SGTC_3264 9137442 49.47 µM 0.893471451819862 0.200735099987248 no 673 0.185802376817857 883 17015726
SGTC_835 0312-0010 67.2 µM 0.892194745621661 0.20107779966772 no 674 0.186144279020713 882 1626196
SGTC_2276 7947513 42.08 µM 0.891443295164437 0.201279671601864 no 675 0.186345699802431 857 2105100
SGTC_2881 9058953 51.95 µM 0.890656702334456 0.201491114394628 no 676 0.186556684826736 976 17122249
SGTC_2437 5741531 144.16 µM 0.890456074738424 0.201545066081824 no 677 0.186610522128023 962 2262990
SGTC_2138 5575593 77.673 µM 0.889727305874605 0.20174111547061 no 678 0.186806164131475 922 762213
SGTC_1916 st067606 49.2 µM 0.889357473136126 0.201840649508521 no 679 0.186905496300795 951 19590279
SGTC_2066 5222451 176 µM 0.888257875045505 0.202136760800738 no 680 0.187201026767962 1000 2281147
SGTC_263 alizarin 107.927 µM 0.888102387752437 0.202178653013705 no 681 0.187242839191339 978 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2438 5259590 200 µM 0.887560032229653 0.202324817974889 no 682 0.187388730381062 972 1201127
SGTC_3156 9099931 49.47 µM 0.886490290450355 0.202613298873821 no 683 0.187676692001468 973 18111053
SGTC_2616 abietic acid 100 µM 0.885961386913074 0.202756020866112 no 684 0.187819167409809 971 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3178 9107506 49.47 µM 0.884236950228229 0.203221768563217 no 685 0.188284157868986 911 8897194
SGTC_3193 9111931 49.47 µM 0.882467676353152 0.203700289268631 no 686 0.188761976049564 923 17087244
SGTC_855 0428-0020 25 µM 0.881744925960032 0.203895958629709 no 687 0.188957380130321 848 6812414
SGTC_1578 josamycin 24.2 µM 0.880466975000465 0.204242210789714 no 688 0.189303194063488 856 5282165 A P450 substrate.
SGTC_2127 5253358 187.912 µM 0.877418510138508 0.205069584252333 no 689 0.190129681424783 840 20612
SGTC_2011 4012611 177 µM 0.876923784592616 0.205204043654064 no 690 0.190264018215409 933 2049887
SGTC_2420 aureobasidin a 50 nM 0.875526607234881 0.205584059447272 no 691 0.190643719730808 971 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1873 rapamycin 2 nM 0.874432949229766 0.205881812844736 no 692 0.190941260118727 962 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_197 4544-0043 41.561 µM 0.873569835165805 0.206116980121455 no 693 0.191176279761397 983 896523
SGTC_211 3455-0679 143.504 µM 0.873480130943936 0.206141430401693 no 694 0.191200715734479 955 748649
SGTC_3306 9127676 59.7925 µM 0.872466997731659 0.206417694974764 no 695 0.191476832277233 914 41905287
SGTC_1376 2910-0861 41.3 µM 0.871055374687312 0.20680298664713 no 696 0.191861959250507 971 1112859
SGTC_410 α-linolenic acid 100 µM 0.867838012338672 0.207682730389881 no 697 0.19274150865991 972 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1231 0242-0792 125 µM 0.867779662661169 0.207698705696989 no 698 0.192757482768675 933 3707635
SGTC_1007 4101-0031 70 µM 0.866239765795378 0.208120569758616 no 699 0.193179345189078 978 1146276
SGTC_552 k242-0005 476 µM 0.865950835948207 0.208199780144921 no 700 0.193258561707747 933 4088318
SGTC_954 1189-0853 2.85 µM 0.865042307462468 0.20844896996189 no 701 0.193507784075815 1008 2828194
SGTC_446 go6976 132 µM 0.864497492306479 0.208598485362359 no 702 0.1936573286566 930 3501 A protein kinase C inhibitor.
SGTC_926 2268-1401 59.4 µM 0.862538442366908 0.209136635977062 no 703 0.194195644090205 998 2931578
SGTC_2444 5485484 36.41 µM 0.862030153881336 0.209276396163784 no 704 0.19433546236329 983 6790631
SGTC_1489 4065-0444 182 µM 0.86058234525407 0.209674790182681 no 705 0.194734056467807 942 2877968
SGTC_3192 9110362 49.47 µM 0.860407825724579 0.209722842885573 no 706 0.194782136753038 984 16649480
SGTC_148 3253-0744 288.01 µM 0.859849138966797 0.209876716822173 no 707 0.194936104002611 969 6893655
SGTC_1701 st028638 40.4 µM 0.859642999717779 0.20993350860759 no 708 0.194992932148033 981 3490878
SGTC_499 genistein 192 µM 0.85836073157348 0.210286978874654 no 709 0.195346651965184 981 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2718 lomofungin 53.02 µM 0.853760512094562 0.211557948744375 no 710 0.196618848997146 933 5351222 A RNA synthesis inhibitor.
SGTC_2035 5154463 94.595 µM 0.852485105077973 0.211911118761046 no 711 0.1969724512919 956 2769623
SGTC_1176 0848-0131 83.3 µM 0.851204317938053 0.212266125405615 no 712 0.197327932313508 1034 6769040
SGTC_2409 alverine citrate 63.97 µM 0.849792711349792 0.212657794780055 no 713 0.197720171310865 960 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_151 3013-0144 2.285 µM 0.847467439588271 0.21330389225061 no 714 0.19836731418723 960 906558 YHR107C CDC12
SGTC_274 sirtinol 40.1 µM 0.846448920687884 0.2135872568691 no 715 0.198651178731532 963 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1186 1319-0216 26 µM 0.846050586084324 0.213698138143646 no 716 0.19876226249104 1028 4565136
SGTC_1363 1636-0063 10.4 µM 0.844844536237331 0.214034061147978 no 717 0.199098822467421 1006 6072185
SGTC_2351 9026858 72.31 µM 0.842513084142492 0.214684314888503 no 718 0.199750409517991 936 1409300
SGTC_841 0251-0215 91.2 µM 0.84012390520891 0.215351858463909 no 719 0.200419459009698 1020 3888614
SGTC_1403 3909-7815 62.9 µM 0.839837820489571 0.215431872030214 no 720 0.200499662379321 949 6615483
SGTC_1284 0929-0043 16 µM 0.839549043458264 0.215512656082809 no 721 0.200580640079334 982 1239883
SGTC_588 3970-1144 52.9 µM 0.839487541373065 0.215529863278745 no 722 0.200597888784279 970 1888707
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.837159468105749 0.216181802738688 no 723 0.201251468514759 1017 6708739 YPR165W RHO1
SGTC_3327 9140648 26.9345 µM 0.836596977032557 0.216339490423752 no 724 0.201409572689128 991 8029710
SGTC_857 0438-0306 1.35 µM 0.836459014680656 0.216378176694056 no 725 0.201448362311967 995 4686136
SGTC_1814 st052110 31.539 µM 0.836024944646537 0.216499921164343 no 726 0.201570435043863 999 674163
SGTC_808 0711-0032 135 µM 0.835909375886908 0.216532341639952 no 727 0.201602943706431 1008 4252555
SGTC_594 1487-1584 10.8 µM 0.835462863121327 0.216657628144403 no 728 0.201728574049445 1011 5013332
SGTC_1328 1441-0025 69.2 µM 0.835263516614404 0.216713576087583 no 729 0.2017846771 949 4562601
SGTC_324 1315-0088 19.6 µM 0.834947067920708 0.21680240670733 no 730 0.20187375597063 950 6787421
SGTC_3123 9126162 49.47 µM 0.833229687518806 0.217284861248388 no 731 0.202357601211423 1017 25239884
SGTC_850 0388-0143 75.9 µM 0.83261437704232 0.217457867905891 no 732 0.202531123991192 959 67273
SGTC_3179 9107801 49.47 µM 0.83254511802956 0.217477346419253 no 733 0.2025506611891 1024 4818259
SGTC_2536 dehydroabietamide 32.04 µM 0.832298198335908 0.21754679869686 no 734 0.202620323658551 1018 3983547
SGTC_88 0180-0332 8.668 µM 0.831748607439572 0.217701430692859 no 735 0.202775428947221 1062 3101745
SGTC_2176 5809774 33.9695 µM 0.831490241736901 0.217774145951862 no 736 0.202848369303196 1022 2870539
SGTC_875 0709-0210 25.7 µM 0.831176538409557 0.217862454436904 no 737 0.202936953332457 1077 6251364
SGTC_1263 0774-1208 64.8 µM 0.827906296687558 0.218784266916025 no 738 0.203861784341943 1044 906585
SGTC_573 3702-0553 84.7 µM 0.826413370560471 0.219205836515415 no 739 0.204284820670761 975 1222756
SGTC_1909 st060837 51.5 µM 0.826380293844846 0.219215181939018 no 740 0.204294199220922 934 678937
SGTC_1218 1348-1416 30.7 µM 0.825891969672771 0.219353178640774 no 741 0.204432688163007 1030 6787668
SGTC_2680 butyl paraben 22.24 µM 0.824123331318477 0.219853400022806 no 742 0.204934742247355 1023 7184 An antifungal and steroid mimetic.
SGTC_2841 9004761 38.96 µM 0.822593578405222 0.220286585340485 no 743 0.205369575821424 980 2991039
SGTC_3047 9092122 49.47 µM 0.821807352500008 0.220509413847017 no 744 0.205593274244257 994 17173831
SGTC_1906 st060206 94.7 µM 0.821739745115296 0.220528580847971 no 745 0.205612516771733 1046 5133468
SGTC_728 3030-5151 22.5 µM 0.821481406686653 0.22060182975987 no 746 0.20568605533662 963 3125388
SGTC_1713 st033146 12.748 µM 0.819215021638275 0.2212450346061 no 747 0.206331872963103 1001 674619
SGTC_2364 9055074 200 µM 0.819005584493955 0.221304527405621 no 748 0.206391613708444 997 6470630
SGTC_2186 6124449 200 µM 0.818520687851847 0.221442302448526 no 749 0.206529967026107 999 3834182 YLR033W RSC58
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.81844742778382 0.221463122300464 no 750 0.206550874758807 1081 66535 A nucleotide analog.
SGTC_1786 berberine 21.6 µM 0.817919444652985 0.221613203445467 no 751 0.20670159323933 958 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_670 4204-0025 119 µM 0.81448349437739 0.222591303725652 no 752 0.207684012039876 1046 719039
SGTC_1926 methyl fluorone black 53.6 µM 0.814342778214417 0.222631413308538 no 753 0.20772430480475 923 72721 Reacts with homocysteine.
SGTC_2293 7624732 200 µM 0.814335222162012 0.222633567194095 no 754 0.207726468540731 1016 894453
SGTC_1458 k015-0034 6.33 µM 0.814287051209378 0.222647298812625 no 755 0.207740262990906 984 3598957
SGTC_2267 7931562 200 µM 0.814198466700568 0.222672551985371 no 756 0.20776563186085 915 934880
SGTC_124 0136-0217 7.121 µM 0.814186100419382 0.222676077425009 no 757 0.207769173467355 1164 3976905
SGTC_2833 9001315 45.46 µM 0.813513983894121 0.222867735525404 no 758 0.207961716031371 981 2989378
SGTC_1943 st076331 65.2 µM 0.812380085777208 0.223191286370991 no 759 0.208286784763734 1105 24208415
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.811515419258331 0.223438193233764 no 760 0.208534870844315 1080 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2800 7887935 81.82 µM 0.810556666890917 0.223712148047953 no 761 0.208810155188974 975 2961002
SGTC_290 2043-6722 48.1 µM 0.808874789647646 0.224193190289054 no 762 0.209293585660042 1018 773758 YLR208W SEC13
SGTC_2750 bromebric acid 70.15 µM 0.808491890108348 0.224302787355591 no 763 0.209403736395254 1054 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1985 st071382 65.5 µM 0.808061184814685 0.224426104170914 no 764 0.209527680421993 1101 6123237
SGTC_20 0481-0013 4.944 µM 0.807793551052293 0.22450275075579 no 765 0.209604719102311 1053 182045
SGTC_3227 9130768 49.47 µM 0.803704003087266 0.225675786362638 no 766 0.210783970842005 1056 17720899
SGTC_2040 5100729 123 µM 0.802606296855974 0.225991238950351 no 767 0.21110116383168 1030 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1896 st058441 89 µM 0.802068225335373 0.226145957887462 no 768 0.211256746996628 942 688759
SGTC_2194 5927483 104.545 µM 0.801884782159328 0.22619871944901 no 769 0.211309804869682 1085 760979
SGTC_470 aa-861 153 µM 0.801432244876543 0.2263289070611 no 770 0.211440727092802 1060 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2233 sulbentine 40.3845 µM 0.801237126981342 0.226385052359981 no 771 0.211497190727284 1064 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2661 dactinomycin 12.96 µM 0.800363447018246 0.226636550772371 no 772 0.211750126359744 1066 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2394 5221648 200 µM 0.799535798604124 0.226874943879045 no 773 0.211989898774257 1113 788586
SGTC_3091 9116372 49.47 µM 0.799026934451442 0.227021585613613 no 774 0.212137397155601 998 17169793
SGTC_617 3770-0098 35 µM 0.798889580255009 0.227061176765233 no 775 0.21217722065929 999 5962639
SGTC_1299 1079-1439 3.74 µM 0.798630203677678 0.227135950421463 no 776 0.21225243438639 1037 323161
SGTC_2223 6903751 107.57 µM 0.797741187492749 0.227392343277375 no 777 0.212510348514734 986 5598863
SGTC_1503 4585-0012 61.3 µM 0.796970754689166 0.227614668416941 no 778 0.212734008197894 1040 2922052
SGTC_1019 4262-0212 3.4 µM 0.796347666246427 0.227794563616542 no 779 0.212914993709819 1136 4677213
SGTC_2824 7998404 51.95 µM 0.796170955814571 0.227845597191672 no 780 0.21296633829265 990 837851
SGTC_1796 st049173 110.4 µM 0.795806410584743 0.227950897356928 no 781 0.213072282552353 1013 94134
SGTC_2974 9094440 9.66 µM 0.795033344331764 0.228174290809605 no 782 0.213297053038661 1049 25236134
SGTC_1287 0971-0001 34.6 µM 0.794677612938485 0.228277128076613 no 783 0.213400529046933 1055 4665869
SGTC_1929 genistein trimethyl ether 50.5 µM 0.794244113618828 0.228402482238394 no 784 0.213526665925995 1082 136420
SGTC_1141 3253-0389 52.6 µM 0.793584248109018 0.228593368503861 no 785 0.213718752780708 1051 5402031
SGTC_816 0325-0417 81.3 µM 0.793001257667755 0.228762090830541 no 786 0.213888545018006 1052 68101
SGTC_992 3909-8734 162 µM 0.792760008885483 0.228831930698986 no 787 0.213958830151859 1059 4288319
SGTC_403 arphamenine a 50 µM 0.788441889445235 0.230084019037361 no 788 0.215219138280741 1034 5487158 An arginine aminopeptidase inhibitor.
SGTC_396 dithiazanine 1.25 µM 0.786948053860018 0.230518064613821 no 789 0.215656137783352 1017 10578 An antihelmenthic.
SGTC_3328 9140624 29.0385 µM 0.785722154323225 0.230874600892632 no 790 0.216015140574837 1077 4904392
SGTC_1049 3226-0134 66 µM 0.785140955567773 0.231043742220477 no 791 0.216185464639984 1100 5702385
SGTC_1020 4335-0961 93.3 µM 0.784736939078583 0.231161360439714 no 792 0.216303910097516 974 669075
SGTC_455 paf C-16 10 µM 0.784350815269165 0.231273800917164 no 793 0.216417145061209 1031 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1343 1487-0095 224 µM 0.782776126196254 0.2317326711459 no 794 0.216879294679757 1061 4560101 YGL055W OLE1
SGTC_869 0564-0080 44.1 µM 0.782288560301709 0.231874852434872 no 795 0.217022504163335 1026 6843321
SGTC_1042 0350-0096 82 µM 0.782250351931164 0.23188599660273 no 796 0.21703372916219 1032 3122515
SGTC_1552 6-methylflavone 10.6 µM 0.78183588378231 0.23200690296155 no 797 0.217155514732052 1036 689013
SGTC_566 0958-0068 16.5 µM 0.781209549609116 0.232189680287963 no 798 0.217339629008732 1024 6815365
SGTC_3073 9114972 49.47 µM 0.779810744672733 0.232598169819365 no 799 0.217751140491436 987 41905075
SGTC_3337 9144342 33.5465 µM 0.779616141685544 0.232655030886977 no 800 0.217808425929676 1070 17682949
SGTC_1486 3970-0793 4.53 µM 0.778123358599696 0.233091464202024 no 801 0.218248146688307 1096 2844330
SGTC_3206 9114350 49.47 µM 0.777345651384623 0.233319016352511 no 802 0.218477434056508 984 17087243
SGTC_1213 1315-0166 115 µM 0.776968979906987 0.233429272309193 no 803 0.218588535991511 975 768401
SGTC_3238 9133470 49.47 µM 0.775040059632997 0.233994341611369 no 804 0.219157994303761 1074 3534688
SGTC_2146 5545642 200 µM 0.771763977878697 0.23495579030615 no 805 0.220127115178621 1123 825326
SGTC_2601 securinine 100 µM 0.771353651517803 0.235076364543063 no 806 0.220248669688959 1059 442872 A GABA receptor antagonist.
SGTC_2496 diffractaic acid 79.83 µM 0.769469438995213 0.235630478236715 no 807 0.220807340094491 1079 94870 An apoptosis inducer which activates caspases.
SGTC_3175 9106517 49.47 µM 0.768621088158848 0.23588019828165 no 808 0.221059141428173 1062 41468073
SGTC_247 mechlorethamine 29.705 µM 0.768059775313025 0.236045506157201 no 809 0.221225836522209 1032 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2452 5863136 48.41 µM 0.766880566199455 0.236392993666494 no 810 0.221576264591225 1090 2184096
SGTC_960 1222-0186 7.7 µM 0.765424899938521 0.236822335226859 no 811 0.222009285238553 1075 3126296
SGTC_1415 3966-0071 78.1 µM 0.765132787971379 0.236908543832302 no 812 0.222096238677312 1083 2893185
SGTC_3074 9116018 49.47 µM 0.765034256329906 0.236937626556918 no 813 0.222125573133333 1112 17027303
SGTC_870 0573-2213 57.6 µM 0.764506614091072 0.237093399500686 no 814 0.222282698347316 1102 3916321
SGTC_2988 9073640 71.4286 µM 0.763490348160623 0.237393584662232 no 815 0.222585508165521 1077 9102229
SGTC_233 rapamycin 362 pM 0.762804389937999 0.237596321263103 no 816 0.2227900313276 1132 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_745 0469-0705 296 µM 0.761932728101981 0.23785408003014 no 817 0.223050077730975 1178 3486736
SGTC_1011 4112-3381 17.4 µM 0.759789597573872 0.238488475792794 no 818 0.223690180944399 1104 2877139
SGTC_975 1335-0046 28.5 µM 0.75860689081368 0.238838969334695 no 819 0.22404387468893 1105 16486740
SGTC_425 3825-7017 13.1 µM 0.75750540165568 0.239165647370022 no 820 0.224373565476597 1102 3397440
SGTC_3210 9128157 49.47 µM 0.757277106505958 0.239233385346372 no 821 0.224441931776935 1006 17590849
SGTC_2206 7254556 146.969 µM 0.757086310209338 0.239290004992485 no 822 0.224499077568292 1099 4398905
SGTC_1360 1598-0022 39.8 µM 0.756694461047993 0.23940631091961 no 823 0.224616467003001 1124 761525
SGTC_2027 5150920 200 µM 0.755906411981077 0.239640307581104 no 824 0.224852654657717 1109 786715
SGTC_1355 1499-0035 1.68 µM 0.755799464785244 0.239672073199012 no 825 0.224884718848327 1097 1548538
SGTC_1942 st076330 65.2 µM 0.755735451653638 0.239691087575532 no 826 0.224903912075875 1152 24208414
SGTC_1623 st003709 20.3 µM 0.755090575545394 0.239882686640612 no 827 0.225097318783854 1084 16192618
SGTC_3356 9151811 4.48 µM 0.754825823954439 0.239961371136611 no 828 0.22517674849687 1072 1859254 YPR165W RHO1
SGTC_1651 st011928 86.1 µM 0.75480585598672 0.239967306211741 no 829 0.225182739850488 1081 720198
SGTC_1419 3993-2473 62.6 µM 0.754336562646622 0.240106817225767 no 830 0.225323576490811 1128 704026
SGTC_3088 9117578 49.47 µM 0.753380169502367 0.240391269556822 no 831 0.225610747905033 1165 678341
SGTC_3208 9114115 49.47 µM 0.753229736110691 0.240436028453395 no 832 0.225655936633992 1049 650895
SGTC_1378 2093-0007 380 nM 0.752261014614644 0.240724363749493 no 833 0.225947053796541 1097 3618014
SGTC_2521 angolensin 13.4 µM 0.75121432102109 0.241036118457246 no 834 0.226261841420743 1112 821428 A flavenoid.
SGTC_1626 st003712 1.76 µM 0.750717620377021 0.241184136106445 no 835 0.226411308182175 1055 24207035
SGTC_3320 9137005 35.139 µM 0.748666624051378 0.24179585943878 no 836 0.227029082505129 1057 4908713
SGTC_424 splitomicin 100 mM 0.747779772548324 0.242060629328254 no 837 0.227296502390785 1051 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2828 7998861 71.43 µM 0.746151581139307 0.242547135576265 no 838 0.227787926572903 1036 2988188
SGTC_2957 9076800 11.52 µM 0.743960746575351 0.243202595304086 no 839 0.228450111500546 1064 16459615
SGTC_375 3970-0961 9.27 µM 0.743356681944984 0.243383489243413 no 840 0.228632881497387 1091 2898222
SGTC_2232 chlorophetanol 41.5365 µM 0.74127526685902 0.244007348843852 no 841 0.229263277472578 1201 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1206 3978-0017 132 µM 0.741044135276941 0.244076678761561 no 842 0.22933334011841 1109 3873677
SGTC_1227 3909-8010 46.6 µM 0.740639465317507 0.244198088597072 no 843 0.229456036148562 1091 15982272
SGTC_2131 toluylene red 5.2905 µM 0.74037683484939 0.244276900899855 no 844 0.229535685451542 1101 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.739717658713245 0.244474772255474 no 845 0.229735665433549 1127 2333 A French combination drug.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.73814926848948 0.244945918262865 no 846 0.230211873620232 1136 364106
SGTC_3127 9126946 49.47 µM 0.738050496110506 0.244975605929326 no 847 0.230241882212486 1015 27243249
SGTC_196 k015-0023 18.111 µM 0.736834544519862 0.245341238781542 no 848 0.230611486505396 1130 5211998
SGTC_1375 2910-0797 186 µM 0.73661242679358 0.24540806055911 no 849 0.230679037869526 1110 742508
SGTC_2049 5262831 67.185 µM 0.735956672864452 0.245605394266294 no 850 0.230878532954633 1138 763417
SGTC_1365 1672-3266 55.4 µM 0.73457964615583 0.24602005527619 no 851 0.231297768822533 1143 6415873
SGTC_1621 st003705 32.4 µM 0.73199290513845 0.246800009245255 no 852 0.232086449108755 1174 24207032
SGTC_1671 st016596 74.5 µM 0.730216476069537 0.247336403729679 no 853 0.232628936508304 1190 2829167
SGTC_1487 3970-0795 2.82 µM 0.729815679054016 0.247457510884225 no 854 0.232751429624043 1155 3765103
SGTC_1507 4075-3230 155 µM 0.72736683023269 0.248198157062572 no 855 0.233500634190503 1074 659771
SGTC_1781 st038725 66.3 µM 0.726293770270277 0.248523072594901 no 856 0.233829348799846 1164 4270275 YIL048W NEO1
SGTC_1712 st032288 53.4 µM 0.726251588219656 0.248535849671609 no 857 0.233842275827083 1163 2883011
SGTC_2913 7966556 36.57 µM 0.725829786484188 0.248663633998504 no 858 0.233971562124612 1088 2976516
SGTC_2263 7948595 193.29 µM 0.724515776579991 0.249061935908001 no 859 0.234374572532487 1085 2971371
SGTC_794 k038-0031 316 µM 0.723205992898555 0.24945929430042 no 860 0.234776668753779 1191 6624242
SGTC_1938 st074717 56.4 µM 0.721067680865116 0.250108732517375 no 861 0.235433937244968 1076 17250979
SGTC_1198 1612-1005 86.7 µM 0.720875140639013 0.250167253925634 no 862 0.235493169525773 1195 6998509
SGTC_2656 pseudo-anisatin 100 µM 0.720678912470204 0.250226903732977 no 863 0.235553544809644 1167 6708809 A neurotoxin.
SGTC_1171 0368-0077 21.4 µM 0.719936407094477 0.250452680159093 no 864 0.235782075383555 1132 3239779
SGTC_1679 SEC14.276 6.7 µM 0.71906875920068 0.250716645871426 no 865 0.236049277522896 1192 1005053 YMR079W SEC14
SGTC_3043 9092303 49.47 µM 0.718315383072089 0.250945965974503 no 866 0.23628142362378 1130 25236084
SGTC_2203 7227154 166.4 µM 0.717888813164873 0.251075858759868 no 867 0.236412923040238 1155 896304
SGTC_249 wiskostatin 11.211 µM 0.716661836181482 0.251449677928048 no 868 0.236791389773012 1180 2775510 A n-wasp and actin depolymerizer.
SGTC_2235 salicylic acid 500 µM 0.713937495646401 0.252280744527774 no 869 0.237632915160145 1178 338 A COX inhibitor and kinase inhibitor.
SGTC_1867 st057372 64 µM 0.712294324564475 0.252782697073369 no 870 0.238141268878509 1185 688837
SGTC_2264 7948757 110.76 µM 0.70994714391529 0.253500620014474 no 871 0.238868456970177 1173 2971411
SGTC_2904 7225135 42.03 µM 0.708186658630454 0.254039795033027 no 872 0.239414675016023 1243 4446116
SGTC_2659 sanguinarine 24.21 µM 0.708142565152271 0.254053307040789 no 873 0.239428364456841 1145 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1950 st077106 7.18 µM 0.70683203929661 0.254455076720176 no 874 0.23983543074479 1130 13831864
SGTC_1377 2944-0135 198 µM 0.706722008188365 0.254488824249356 no 875 0.239869625002061 1212 1894137
SGTC_662 k832-1615 104 µM 0.706254383547052 0.25463227508513 no 876 0.240014977905515 1151 5878478
SGTC_3101 9120531 49.47 µM 0.706062224029846 0.254691235158861 no 877 0.240074721234566 1222 24824904
SGTC_3118 9124250 49.47 µM 0.704950402419734 0.255032514343594 no 878 0.240420551088097 1080 1504786
SGTC_1158 4092-0494 91.8 µM 0.704665462610859 0.255120016535076 no 879 0.240509224697204 1230 1148199
SGTC_330 1488-0319 80.1 µM 0.702922942223275 0.255655468711833 no 880 0.24105188639748 1157 6846614
SGTC_3031 9088762 49.47 µM 0.701803949213393 0.255999628823603 no 881 0.24140071779261 1165 205253
SGTC_1302 1159-0335 255 µM 0.701580284954427 0.256068448500067 no 882 0.241470475061986 1173 649284
SGTC_782 0083-0095 30.5 µM 0.70105570054225 0.256229896714546 no 883 0.241634127410348 1208 3591729 An indicator and reagent.
SGTC_1089 terbinafine 2.25 µM 0.69965617422228 0.256660880092025 no 884 0.242071026093192 1179 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1013 4112-3890 241 µM 0.699410408649177 0.256736602412819 no 885 0.242147792426781 1123 705171
SGTC_932 2857-0803 154 µM 0.698446499891436 0.257033702560822 no 886 0.242449002396502 1236 674898
SGTC_774 k060-0086 136 µM 0.69759138470395 0.257297419498365 no 887 0.242716385483097 1226 5911235
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.696896164757092 0.257511928452984 no 888 0.242933889056872 1191 5377381
SGTC_834 0312-0008 75.7 µM 0.695480195159911 0.257949110606586 no 889 0.243377209224884 1214 6385573 YIL048W NEO1
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.694854599567001 0.258142386492005 no 890 0.243573213554295 1194 6312947
SGTC_259 usnic acid 108.925 µM 0.69444533380279 0.258268868540522 no 891 0.24370148605469 1270 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1001 4048-4355 44.4 µM 0.694066383910189 0.258386010215351 no 892 0.243820289433985 1199 21824233
SGTC_138 0850-0259 40.9225 µM 0.693910627160168 0.258434166004497 no 893 0.243869129301612 1235 6813004
SGTC_1850 st056238 17 µM 0.693440368243489 0.258579585591443 no 894 0.244016618072533 1216 5393177
SGTC_2087 5276107 200 µM 0.692165964769471 0.258973886132055 no 895 0.244416554979642 1191 144405
SGTC_387 norethindrone acetate 66.7 µM 0.692077682897904 0.259001212063677 no 896 0.244444272921905 1177 541197
SGTC_2704 st078022 71.1 µM 0.691852630689906 0.259070879331212 no 897 0.244514940436677 1216 54697681
SGTC_448 monastrol 171 µM 0.691361354279349 0.259222992744922 no 898 0.244669241904052 1193 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.691110460126948 0.259300694648829 no 899 0.244748063661802 1216 16623 A steroid.
SGTC_1745 st081495 74 µM 0.690340719393836 0.259539158389793 no 900 0.244989973305096 1166 13842402 YBL026W LSM2
SGTC_945 3381-0768 11.3 µM 0.68881732498157 0.260011435757649 no 901 0.245469115826277 1220 1126236 YIL048W NEO1
SGTC_873 0591-4978 488 µM 0.6880189642526 0.260259117597871 no 902 0.245720419539006 1261 3305145
SGTC_1223 0764-0573 147 µM 0.687466984019519 0.260430433903385 no 903 0.245894249658381 1239 1609797
SGTC_2190 6049624 200 µM 0.686516217828148 0.260725656226062 no 904 0.246193820491392 1142 2265554
SGTC_1841 st054148 70 µM 0.685609926914647 0.261007228765565 no 905 0.246479559983829 1171 675442
SGTC_1960 st011366 51.8 µM 0.685173144846615 0.261142986959853 no 906 0.246617334037956 1235 3972846
SGTC_1939 st074455 53.6 µM 0.684992110235587 0.261199265775824 no 907 0.246674449827162 1232 1644229
SGTC_1665 st014639 11.4 µM 0.684814347544007 0.261254533503552 no 908 0.246730540229527 1281 981133 YIL048W NEO1
SGTC_2714 st079313 56.9 µM 0.68438486723302 0.26138808687948 no 909 0.246866084600824 1209 2939799
SGTC_1228 0124-0032 52.5 µM 0.68402889058779 0.261498809752331 no 910 0.24697846135052 1245 X1228
SGTC_5 0352-0601 109.883 µM 0.683881822175006 0.261544560897214 no 911 0.247024896740015 1136 762456
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.68305854367291 0.261800748410648 no 912 0.24728492498206 1252 1377
SGTC_1296 1068-0102 11.9 µM 0.682174082763722 0.262076117999235 no 913 0.247564440343383 1180 767053
SGTC_2324 6149169 200 µM 0.681830916788254 0.262182999846809 no 914 0.247672936199843 1149 2888231
SGTC_1395 3486-0190 4.35 µM 0.680697444736683 0.262536187626469 no 915 0.248031476766042 1249 6748079
SGTC_501 nsc-95397 161 µM 0.680229660901117 0.262682019155628 no 916 0.248179527118904 1232 262093
SGTC_664 1222-0054 14.9 µM 0.679896434612092 0.262785927663872 no 917 0.248285019675376 1222 6813991
SGTC_3191 9110352 49.47 µM 0.677034976195469 0.263679068357153 no 918 0.249191881536716 1216 17122424
SGTC_1912 st060209 90.8 µM 0.676852743757315 0.263736000567431 no 919 0.249249694786025 1206 688787
SGTC_2332 7982454 138.89 µM 0.674987480510197 0.264319097710155 no 920 0.249841859519661 1218 2981748
SGTC_3319 9138450 16.7555 µM 0.671623216794803 0.2653724520995 no 921 0.250911797083446 1202 2029690
SGTC_631 k072-0230 41.5 µM 0.671502195828428 0.265410383546558 no 922 0.250950330546677 1246 5773147
SGTC_986 1493-0483 84 µM 0.670093136209419 0.265852225716941 no 923 0.251399210052676 1189 40079
SGTC_928 2764-0428 58.7 µM 0.669848105115661 0.265929098729534 no 924 0.251477312099554 1255 662578
SGTC_973 1325-0077 65.9 µM 0.66941309763869 0.266065600313269 no 925 0.251615999448383 1270 2835149
SGTC_2372 9071633 200 µM 0.667783731818204 0.266577196401122 no 926 0.252135826226173 1263 21321366
SGTC_2818 7996756 12.99 µM 0.666887938530282 0.266858673635972 no 927 0.252421857905257 1238 2241621
SGTC_957 1187-1561 14.1 µM 0.666249123034081 0.267059494688617 no 928 0.252625939589891 1218 1538454
SGTC_2642 cholecalciferol 100 µM 0.665419437514295 0.267320432408312 no 929 0.252891127997004 1226 9821465 A vitamin D precursor, similar to steriods.
SGTC_1722 st034304 3.6505 µM 0.66342853055611 0.267947100775943 no 930 0.253528069188994 1263 4036148 YLR033W RSC58
SGTC_1508 1080-0625 72.9 µM 0.661849372074019 0.268444690592179 no 931 0.254033880449362 1189 767111
SGTC_3190 9110366 49.47 µM 0.66104124982738 0.26869950796474 no 932 0.254292930125798 1179 17123768
SGTC_2407 paclitaxel 400 µM 0.660761959955518 0.268787601987939 no 933 0.254382490790092 1338 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_693 4161-2696 114 µM 0.660490959568792 0.268873095194706 no 934 0.254469409042837 1268 805759
SGTC_1470 k295-0292 231 µM 0.660486730508521 0.268874429455703 no 935 0.254470765557307 1292 5045612
SGTC_165 k038-0023 64.381 µM 0.65946404449269 0.269197182660622 no 936 0.254798913804718 1248 46368543
SGTC_2296 7971656 126.45 µM 0.659368148802432 0.26922745669441 no 937 0.254829695115507 1259 666570
SGTC_963 1269-2853 151 µM 0.65658615945569 0.2701064666272 no 938 0.255723525346905 1241 3668223
SGTC_732 3970-1727 52.7 µM 0.655881528106015 0.270329332783557 no 939 0.255950177116267 1268 1275699
SGTC_742 0kpi-0133 140 µM 0.653648078531982 0.271036352101434 no 940 0.256669280717202 1275 2728852
SGTC_3282 9108498 15.4605 µM 0.652534148434752 0.271389321486869 no 941 0.257028325493245 1239 16459645
SGTC_2268 7933382 153.85 µM 0.652291206757765 0.271466332469296 no 942 0.257106665758688 1291 935025 YOR257W CDC31
SGTC_1387 3342-1166 1.8 µM 0.650799746121322 0.271939354530508 no 943 0.257587882065438 1259 3418228
SGTC_713 1488-1073 324 µM 0.648109350592054 0.272793658552216 no 944 0.258457113302899 1241 3312542
SGTC_3111 9122088 49.47 µM 0.647226500382823 0.273074287288777 no 945 0.258742681287325 1196 16876704
SGTC_2936 9038235 15.59 µM 0.647056055314315 0.273128482585278 no 946 0.258797832493447 1266 4749415
SGTC_1255 0566-0045 221 µM 0.642387388049899 0.274615017185113 no 947 0.260310843236846 1320 2788469
SGTC_72 0744-0168 198.391 µM 0.640016679613807 0.275371391198334 no 948 0.261080877808773 1238 677577
SGTC_177 1327-0068 8.361 µM 0.639327210014987 0.275591558588166 no 949 0.261305045403138 1288 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1109 tnp00067 928.257 nM 0.639008917201414 0.27569322779517 no 950 0.261408565453168 1260 676295
SGTC_1094 duloxetine 25.4 µM 0.638651254325601 0.275807494596575 no 951 0.261524915161096 1280 60834 A selective serotonin reuptake inhibitor.
SGTC_919 tnp00227 403.569 nM 0.637076543158151 0.276310862869826 no 952 0.262037493408669 1309 1269246 A methoxyflavone. YNL221C POP1
SGTC_2192 5915882 198.485 µM 0.636993087783053 0.276337552579346 no 953 0.262064673012901 1237 2876149
SGTC_1800 st050079 29.0735 µM 0.636391562003241 0.276529962829533 no 954 0.262260619636437 1256 3645560
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.635487983084924 0.276819114294781 no 955 0.26255510084789 1325 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.631014817185233 0.278252735491757 no 956 0.264015418106328 1315 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_648 0375-0473 33.3 µM 0.627350116997683 0.279429939860389 no 957 0.265214879200895 1309 1713139
SGTC_2519 cryptotanshinone 88.04 µM 0.62717803241802 0.279485277655302 no 958 0.265271270645439 1282 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1283 0922-0125 16.4 µM 0.624535856538715 0.280335598187901 no 959 0.266137864905493 1298 3360884
SGTC_1472 k841-0093 193 µM 0.623256136977134 0.280747894909922 no 960 0.266558108511791 1353 X1472
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.622122689870575 0.281113310671856 no 961 0.266930598137232 1307 5106787 A p450 inhibitor.
SGTC_2647 atorvastatin 60.16 µM 0.621433839294552 0.2813355036722 no 962 0.267157106468347 1325 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_496 calpeptin 138 µM 0.621345228824308 0.281364091678162 no 963 0.267186250467045 1262 73364 A calpain inhibitor.
SGTC_1310 1188-0297 994 nM 0.620996278041326 0.281476685763658 no 964 0.267301036039499 1262 1588352
SGTC_643 k048-0106 28.4 µM 0.620420059544062 0.281662658680964 no 965 0.267490634613212 1350 6763920
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.620200631150371 0.281733494157836 no 966 0.267562853020207 1359 688788
SGTC_1071 trifluoperazine 6.31 µM 0.619946030404381 0.28181569467099 no 967 0.267646659691459 1354 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3125 9127534 49.47 µM 0.618685067394417 0.282222980056405 no 968 0.268061924559565 1221 1639235
SGTC_78 0336-0123 156.75 µM 0.616994333065505 0.282769523818229 no 969 0.268619231792631 1258 6765896
SGTC_15 0266-0086 27.098 µM 0.61694525651328 0.282785395807892 no 970 0.268635417311932 1395 1712902 YIL048W NEO1
SGTC_683 panaxydol 45 µM 0.616790460065549 0.282835461778387 no 971 0.268686472619248 1289 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2807 7945238 51.95 µM 0.61548558339499 0.283257668470888 no 972 0.269117043605068 1355 17148797
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.614388650205064 0.283612826553697 no 973 0.269479267010193 1315 521171
SGTC_1016 4226-1401 38 µM 0.614073789211791 0.28371480964446 no 974 0.269583283840802 1317 2901613
SGTC_546 peri-Naphthalide 147 µM 0.613571212648286 0.283877629958904 no 975 0.269749355673594 1291 223824 A penicillin ester.
SGTC_1338 1486-1223 76 µM 0.609600693821311 0.2851655334896 no 976 0.271063175956324 1380 3444526
SGTC_666 0272-0154 136 µM 0.609073689155356 0.285336685296996 no 977 0.271237798186406 1339 6870312
SGTC_2628 lathosterol 100 µM 0.608682180280044 0.285463864703914 no 978 0.2713675603778 1360 6710616
SGTC_2008 4012253 172 µM 0.607588635643715 0.285819239293525 no 979 0.271730169971902 1338 603940
SGTC_2021 4019055 173 µM 0.607454001011858 0.285863006714893 no 980 0.271774830276598 1338 44827708 YER133W GLC7
SGTC_2128 5255449 168.493 µM 0.607122018605247 0.285970942144934 no 981 0.271884969372573 1314 736008
SGTC_221 trifluoperazine 10.304 µM 0.606261598318571 0.286250775508729 no 982 0.272170527311622 1318 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1247 0448-0043 5.84 µM 0.605802528787811 0.286400131268005 no 983 0.272322945153934 1368 3089013 YGL099W LSG1
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.601464670414864 0.28781325249203 no 984 0.273765268100261 1334 16486 A toxic proline analog.
SGTC_34 0469-0683 81.75 µM 0.599673895825893 0.288397582591686 no 985 0.274361794313683 1363 3690923
SGTC_2619 obliquin 87.91 µM 0.598807738619274 0.288680410381209 no 986 0.274650550617278 1343 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1515 3460-0031 42.1 µM 0.598603681155429 0.288747060620172 no 987 0.274718600352751 1299 2876596
SGTC_3230 9131665 49.47 µM 0.598575784246093 0.288756173007009 no 988 0.274727904149216 1293 15943720
SGTC_2295 7971645 200 µM 0.595833853832477 0.289652470901048 no 989 0.275643112686726 1397 2978226 YKL099C UTP11
SGTC_3329 9141233 27.5565 µM 0.595028020886795 0.289916134258025 no 990 0.275912370384778 1401 4909101 YNL103W MET4
SGTC_39 0986-0283 58.349 µM 0.594680122699259 0.29002999908243 no 991 0.276028655568295 1407 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_213 1246-0773 967 nM 0.593522259840868 0.290409111011262 no 992 0.276415845185248 1341 6251622
SGTC_440 fluspirilene 35.1 µM 0.59250524794757 0.29074229623599 no 993 0.276756153792111 1429 3396 An atypical antipsychotic.
SGTC_462 ag-879 158 µM 0.591616736669907 0.29103352934868 no 994 0.27705363191226 1352 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_162 k030-0015 37.8 µM 0.591040303965237 0.291222543297395 no 995 0.277246708193494 1409 1809920 YMR134W ERG29
SGTC_1425 4048-4433 7.33 µM 0.589672415164159 0.29167130719043 no 996 0.27770514612495 1383 23734946
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.588773241237593 0.291966475057318 no 997 0.278006699235977 1353 23665772 A membrane-active detergent.
SGTC_275 trichlorophene 5.69 µM 0.588420751922527 0.292082223111179 no 998 0.278124956039541 1394 62616
SGTC_1133 3473-0247 50 µM 0.587656361082077 0.292333301949125 no 999 0.278381486140022 1319 711311
SGTC_1791 st048313 56.1 µM 0.582341107797691 0.294081967990745 no 1000 0.2801684707039 1336 1204976
SGTC_1084 voriconazole 435 nM 0.581831220034971 0.294249969876899 no 1001 0.280340186358334 1370 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2382 9035899 200 µM 0.580691822747206 0.294625547711927 no 1002 0.280724086956252 1381 6462679
SGTC_1193 1488-0126 41.5 µM 0.580688208989472 0.294626739261252 no 1003 0.28072530495504 1366 1384710
SGTC_1261 0712-0010 12.7 µM 0.578898567929873 0.29521710312063 no 1004 0.281328808276943 1410 2840123
SGTC_3169 9102970 49.47 µM 0.577059874792998 0.295824214731385 no 1005 0.28194950446335 1416 17027839
SGTC_721 1187-1332 279 µM 0.576601923477466 0.295975513223971 no 1006 0.28210419976685 1312 25730
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.575515180459159 0.296334694761067 no 1007 0.282471463479004 1368 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2566 crystal violet carbinol 226 nM 0.573653787437425 0.296950371238197 no 1008 0.283101053047375 1312 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1277 0873-0036 22 µM 0.573565263901173 0.296979665956038 no 1009 0.283131011634104 1463 5965735
SGTC_753 1322-0200 289 µM 0.5727388758908 0.297253202782349 no 1010 0.283410755441157 1378 5403907
SGTC_1897 st060201 15 µM 0.572437407880131 0.297353018222544 no 1011 0.283512839520813 1347 611878
SGTC_1732 st034308 51.822 µM 0.571938654714102 0.29751818798545 no 1012 0.283681767624824 1362 830119
SGTC_783 0848-0141 92.7 µM 0.570922833726168 0.297854722161079 no 1013 0.284025976032348 1372 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2888 9058547 12.99 µM 0.570890533022302 0.297865425998651 no 1014 0.284036924322217 1311 16476514
SGTC_2822 7994718 71.43 µM 0.568459157291184 0.298671640558 no 1015 0.284861615599084 1388 1018011
SGTC_1845 st056753 3.01 µM 0.568343999838347 0.298709849962554 no 1016 0.284900703838369 1318 5375839
SGTC_2130 NSC 7 2.4545 µM 0.566287310780172 0.299392636187124 no 1017 0.285599242506756 1422 21448
SGTC_431 k089-0097 107 µM 0.564962583014218 0.299832797949163 no 1018 0.286049607290285 1333 5499420
SGTC_2657 nystatin 74.44 µM 0.563861728407534 0.300198797049573 no 1019 0.286424118960255 1404 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.562901156984094 0.3005183213881 no 1020 0.286751096164179 1407 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3003 9075612 71.4286 µM 0.56169156006553 0.30092089985748 no 1021 0.287163092841944 1391 6501993
SGTC_3023 9089636 49.47 µM 0.560815591725715 0.301212591685673 no 1022 0.287461628267744 1464 17249241
SGTC_1493 4348-0038 111 µM 0.559923218727046 0.301509877054534 no 1023 0.287765905341761 1438 800424
SGTC_1408 3909-7976 48.8 µM 0.559759569806498 0.30156440942033 no 1024 0.287821722073561 1421 24152374
SGTC_2568 diosmetin 100 µM 0.559750611489066 0.301567394708612 no 1025 0.287824777688949 1397 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1999 st074831 12.5 µM 0.559207722112396 0.301748333100124 no 1026 0.288009981807857 1367 17112523
SGTC_1812 st052057 4.327 µM 0.55878403141462 0.301889577928319 no 1027 0.288154560937721 1359 3645418
SGTC_1933 st074711 15.9 µM 0.555855269236962 0.302866744188969 no 1028 0.289154899487904 1361 17250958
SGTC_2068 5226020 147 µM 0.555750852465604 0.302901608430905 no 1029 0.289190593867888 1379 1810509
SGTC_914 3820-6779 408 µM 0.554844349352096 0.303204360793368 no 1030 0.289500564697542 1371 2893481
SGTC_2430 5571206 200 µM 0.554580740449109 0.303292425832618 no 1031 0.289590732737287 1445 1731771
SGTC_2041 5107442 45.335 µM 0.554488261557966 0.303323323390207 no 1032 0.28962236848142 1422 793005
SGTC_554 4483-2211 187 µM 0.553983463918595 0.303492003038878 no 1033 0.289795081333086 1408 747107
SGTC_1646 st011709 75.6 µM 0.552072774346537 0.304130844770803 no 1034 0.290449247108984 1410 5757843
SGTC_1251 0490-5699 265 µM 0.550683387055267 0.304595764291372 no 1035 0.290925367454112 1460 3883818
SGTC_228 caffeine 993.056 µM 0.549872801221023 0.304867150060921 no 1036 0.291203310353765 1427 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_895 0964-0006 13.7 µM 0.549459918059339 0.305005425464745 no 1037 0.291344932073835 1379 6738897
SGTC_3100 9120536 49.47 µM 0.549250825842737 0.305075461492922 no 1038 0.291416664377514 1360 16421196
SGTC_272 doxorubicin 8.13 µM 0.548314770542397 0.305389083353656 no 1039 0.291737893523144 1407 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_398 bronopol 33.3 µM 0.54793839445969 0.305515227057572 no 1040 0.291867102226293 1418 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2029 5175081 200 µM 0.547419605145764 0.305689138880544 no 1041 0.292045244615538 1392 1380876
SGTC_2251 lansoprazole 556 µM 0.547096175648865 0.305797583141987 no 1042 0.292156329764626 1344 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2774 tamoxifen 10.92 µM 0.545108469737656 0.306464424486284 no 1043 0.29283945890656 1438 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2014 4013930 200 µM 0.544836954085977 0.306555563182389 no 1044 0.292932830169715 1387 64556
SGTC_625 k213-0058 121 µM 0.544369512588869 0.306712495640639 no 1045 0.29309361054749 1483 3655420
SGTC_504 lovastatin 124 µM 0.543774986622742 0.306912144910975 no 1046 0.293298161794857 1380 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2626 ethyl orsellinate 100 µM 0.540976479707801 0.307852687209563 no 1047 0.29426189724514 1392 75653 A natural product.
SGTC_2271 7849410 118.62 µM 0.538454358912751 0.308701422856442 no 1048 0.295131703354445 1433 972430
SGTC_2446 5162541 200 µM 0.538274885254774 0.308761857766144 no 1049 0.295193643695307 1381 1549321
SGTC_2385 9074692 200 µM 0.53823245947483 0.308776144732022 no 1050 0.295208286647692 1398 17046906
SGTC_82 0054-0107 293.755 µM 0.537038671355491 0.309178273832777 no 1051 0.295620451026594 1458 3104697
SGTC_2241 6772625 37.8075 µM 0.535224955887964 0.309789663909145 no 1052 0.296247155736799 1382 2285411
SGTC_208 k072-0098 12.366 µM 0.534951454826116 0.30988190482229 no 1053 0.296341713157375 1416 5948901
SGTC_3060 1327-0027 12.5 µM 0.534890318169823 0.309902525395791 no 1054 0.296362851803073 1389 16000455 YPR107C YTH1
SGTC_1825 st052143 62.6 µM 0.534585664517355 0.310005289897809 no 1055 0.296468199330514 1494 674173
SGTC_1895 st058434 18.3 µM 0.532979905303005 0.310547183074572 no 1056 0.297023745274833 1481 5393175
SGTC_2234 tolnaftate 200 µM 0.53285203642803 0.310590352492356 no 1057 0.297068004643702 1428 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_3110 9122132 49.47 µM 0.532305039252507 0.310775051967061 no 1058 0.297257371305884 1509 918317
SGTC_1331 1472-0049 76.2 µM 0.530603274622918 0.311349975922513 no 1059 0.29784686299921 1387 24051409
SGTC_1633 st005664 67.9 µM 0.529835011786296 0.311609676683907 no 1060 0.298113163983502 1421 2063822
SGTC_3336 9143619 71.43 µM 0.529322611833669 0.311782938610014 no 1061 0.298290836147622 1457 45595730
SGTC_373 0844-0104 25.9 µM 0.5292137882858 0.311819741359092 no 1062 0.298328576383737 1476 5375804
SGTC_1262 0737-0114 49.6 µM 0.525250698046657 0.313161286327645 no 1063 0.299704462758376 1462 765919
SGTC_2204 7233102 200 µM 0.52517813458662 0.313185872913953 no 1064 0.299729681763073 1448 2172480
SGTC_3302 9125395 16.351 µM 0.525000809183433 0.313245959352772 no 1065 0.299791314210136 1491 17599668
SGTC_876 0720-0963 56.8 µM 0.523167954048887 0.31386730973506 no 1066 0.300428689961724 1561 765861
SGTC_906 1165-0455 526 µM 0.523114574882137 0.313885413560146 no 1067 0.300447261748878 1404 3252859
SGTC_360 0957-0399 1.01 µM 0.521717630534163 0.314359353762199 no 1068 0.300933473697517 1533 6752301 YPR165W RHO1
SGTC_740 k014-0057 261 µM 0.521448135351368 0.314450820433548 no 1069 0.301027313361941 1540 4012779
SGTC_1461 k072-0203 53.8 µM 0.521231955450043 0.314524200131271 no 1070 0.301102597892892 1379 5418714
SGTC_1305 1181-0477 144 µM 0.521219192653558 0.314528532539922 no 1071 0.301107042794936 1525 6252086
SGTC_1991 st073000 8.92 µM 0.521136673880348 0.314556544654186 no 1072 0.301135782340514 1499 4301969 YIL048W NEO1
SGTC_1602 st001878 87.6 µM 0.5211040212429 0.314567629328636 no 1073 0.301147154905677 1472 595405 YLR310C CDC25
SGTC_304 1310-0298 97 µM 0.51965288141357 0.315060420133816 no 1074 0.301652766691087 1388 1550234
SGTC_3120 9124077 49.47 µM 0.518164366797459 0.315566245214021 no 1075 0.302171797020177 1465 18774327 YGL155W CDC43
SGTC_355 1311-2252 105 µM 0.517575459511095 0.315766462422683 no 1076 0.30237725377962 1413 5338538
SGTC_372 0155-0182 15.9 µM 0.5170520456584 0.315944458508103 no 1077 0.302559913899145 1476 771486
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.516150032216382 0.316251304181182 no 1078 0.302874813086556 1444 2724 A muscle relaxant with antifungal properties.
SGTC_111 0083-0039 52.457 µM 0.516141341345432 0.316254261245506 no 1079 0.302877847843814 1404 759313
SGTC_141 0443-0274 32.331 µM 0.513382121439306 0.31719367764382 no 1080 0.303842024652826 1520 1627241
SGTC_2720 fluspirilene 36.88 µM 0.511625773509342 0.317792266375435 no 1081 0.304456471923178 1488 3396 An atypical antipsychotic.
SGTC_2064 5220758 200 µM 0.51075101575163 0.318090574317536 no 1082 0.304762706578502 1491 788518
SGTC_1698 5-fluorocytosine 1.055 µM 0.51057592593359 0.318150297242167 no 1083 0.304824018356644 1509 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_342 k048-0088 23.3 µM 0.508869559220997 0.318732584246698 no 1084 0.305421829206558 1428 6820570
SGTC_1610 st001799 48.1 µM 0.508130061979342 0.318985072253023 no 1085 0.305681067054819 1419 621897
SGTC_1490 4089-0339 670 nM 0.508068235541999 0.319006185583206 no 1086 0.30570274532004 1488 742542
SGTC_338 4055-0136 114 µM 0.506667340514744 0.31948473950407 no 1087 0.306194124940306 1432 2900563
SGTC_2512 diallyl trisulfide 49.23 µM 0.505404798978204 0.319916288814542 no 1088 0.306637274458645 1441 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_32 0928-0142 34.1 µM 0.505284436886541 0.319957442519387 no 1089 0.306679536085379 1459 2244242
SGTC_3090 9117696 49.47 µM 0.501240322129478 0.321341474662112 no 1090 0.308100999798339 1569 7923821
SGTC_2896 9052656 71.43 µM 0.498790833115263 0.322180981796336 no 1091 0.308963373069848 1444 6469436
SGTC_1383 3049-0032 20.7 µM 0.496909142602489 0.322826505760109 no 1092 0.309626561999477 1577 712864
SGTC_2303 7774051 200 µM 0.494871450333074 0.323526149455587 no 1093 0.310345432297512 1570 2953184
SGTC_1795 st049545 62.3 µM 0.493923374015703 0.323851885395602 no 1094 0.310680148173469 1527 5291882
SGTC_106 0092-0003 11.579 µM 0.493261562102104 0.324079347857664 no 1095 0.310913892077278 1559 1072148
SGTC_977 1348-1378 135 µM 0.493009218106201 0.324166094918422 no 1096 0.311003037003339 1452 X977
SGTC_2853 9015042 58.44 µM 0.490126941396621 0.325157597363282 no 1097 0.312022037377866 1410 6457456
SGTC_1037 k284-1091 78.7 µM 0.489796174468667 0.325271460499256 no 1098 0.312139069012695 1472 3334711
SGTC_2001 4023502 57.655 µM 0.488661313371201 0.325662248799339 no 1099 0.312540748544196 1545 108941 YCR052W RSC6
SGTC_1417 3966-0327 90.4 µM 0.488181630368821 0.325827484824751 no 1100 0.312710597435388 1541 651118
SGTC_1043 0916-0009 19.3 µM 0.48652289505301 0.326399131651783 no 1101 0.313298238306824 1678 3101130
SGTC_2560 caryophyllene 100 µM 0.485452436587415 0.326768258438406 no 1102 0.313677722040297 1511 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_38 0929-0051 58.268 µM 0.484669990763216 0.327038176991782 no 1103 0.313955228425468 1609 1379719
SGTC_608 k048-0125 159 µM 0.484433767916496 0.327119684041521 no 1104 0.314039029164662 1544 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2478 5763493 32.33 µM 0.484047380127016 0.327253022233553 no 1105 0.314176122023284 1546 1365576 YLR208W SEC13
SGTC_2847 9005661 71.43 µM 0.482809409670804 0.32768038068319 no 1106 0.314615534476165 1462 2991449
SGTC_1961 st076550 68.7 µM 0.481206918245348 0.328233910343892 no 1107 0.315184722193776 1509 1579337
SGTC_2845 9003024 42.97 µM 0.477858752961982 0.329391644227298 no 1108 0.316375370264464 1590 2990173
SGTC_2170 morpholine 200 µM 0.477793005259756 0.329414395000497 no 1109 0.316398770062809 1588 121171 Reacts with secondary amines.
SGTC_451 chloral hydrate 100 µM 0.477685677065909 0.329451535288663 no 1110 0.316436970058381 1542 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_3168 9103419 49.47 µM 0.474830030899128 0.330440331748163 no 1111 0.317454063078367 1506 16649256
SGTC_752 1896-0090 130 µM 0.47369884161156 0.330832345570023 no 1112 0.317857339756594 1517 772567
SGTC_2946 9065502 71.43 µM 0.4730155282473 0.331069237864873 no 1113 0.318101050367232 1423 16489101
SGTC_2764 methyldopa 94.69 µM 0.472466833684544 0.331259509243726 no 1114 0.318296804858726 1609 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1052 3253-3998 198 µM 0.471476369612204 0.331603083781031 no 1115 0.318650295295458 1483 5450317
SGTC_1725 st036284 20.55 µM 0.47101699109099 0.331762482224505 no 1116 0.318814300683017 1686 707914
SGTC_1927 st060202 13.8 µM 0.469209709683197 0.332389881091193 no 1117 0.319459872905526 1565 688887
SGTC_2120 5538279 151.968 µM 0.468359140746443 0.332685319367865 no 1118 0.319763891081057 1557 2058197
SGTC_2804 7954240 19.48 µM 0.466223395111402 0.333427611250201 no 1119 0.32052780251781 1629 828705
SGTC_913 3487-1245 167 µM 0.463306919210559 0.334442304785265 no 1120 0.321572193441575 1462 4016153
SGTC_574 1315-0397 40 µM 0.463203838669472 0.334478190521947 no 1121 0.321609132494208 1514 6794277
SGTC_1947 st076332 61.6 µM 0.46275376582837 0.334634893438813 no 1122 0.321770437370082 1555 24208416
SGTC_943 3253-1379 105 µM 0.461308907754447 0.335138147637427 no 1123 0.322288497490069 1607 668464
SGTC_681 1642-0006 26.6 µM 0.459300804016294 0.335838075843658 no 1124 0.32300908523838 1514 4446530
SGTC_2675 theaflavin digallate 100 µM 0.458958969125509 0.335957279834184 no 1125 0.323131815528143 1554 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_3349 9149703 23.001 µM 0.458461016748793 0.336130954333581 no 1126 0.323310631730027 1493 4910494
SGTC_2859 9028643 45.46 µM 0.458397932158352 0.336152959306082 no 1127 0.323333288511419 1552 17151580
SGTC_3087 9117406 49.47 µM 0.458234398463472 0.336210005239829 no 1128 0.323392024560726 1522 42546093
SGTC_1966 st070145 16.1 µM 0.456884895236197 0.336680900254949 no 1129 0.323876890682621 1499 3748532
SGTC_2781 5567276 71.43 µM 0.454685599199792 0.337448870294967 no 1130 0.324667721306728 1593 2853274
SGTC_1053 3366-3204 134 µM 0.454563889167075 0.337491389917923 no 1131 0.324711509362108 1508 3632071 YPR165W RHO1
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.454105258371685 0.3376516320642 no 1132 0.324876534370169 1584 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_3260 9137109 49.47 µM 0.453613366492413 0.337823528100301 no 1133 0.325053565617541 1612 17478346
SGTC_2404 5161160 200 µM 0.450743335046623 0.338827159937645 no 1134 0.326087272802966 1600 2831543
SGTC_2386 9075165 157.42 µM 0.44996833335775 0.339098369811443 no 1135 0.326366637047604 1520 16452277
SGTC_2475 5812728 15.03 µM 0.447649945769337 0.339910181110815 no 1136 0.327202925576761 1513 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_345 1362-0200 395 µM 0.447391825867183 0.340000610930241 no 1137 0.327296088349424 1509 1419823
SGTC_472 calcifediol 10 µM 0.447364057647906 0.34001033980673 no 1138 0.327306111326157 1569 5283731 A vitamin D metabolite.
SGTC_2098 5376439 882.5 nM 0.447223463990774 0.340059599851735 no 1139 0.32735686071003 1658 2844116
SGTC_1902 st060212 70.5 µM 0.446958918964234 0.340152296356162 no 1140 0.327452360845611 1527 688944
SGTC_3044 9093193 49.47 µM 0.445563150345591 0.340641533154168 no 1141 0.327956416894443 1498 25236277
SGTC_298 1391-0729 10 µM 0.44499722179759 0.340839975649907 no 1142 0.328160880923708 1545 3237558
SGTC_400 oxethazaine 37.5 µM 0.444286131890974 0.341089381329148 no 1143 0.328417863224046 1539 4621 A local anesthetic.
SGTC_2000 st075254 36.4 µM 0.443505066667138 0.3413634099905 no 1144 0.328700227629437 1540 17234175
SGTC_1524 corynanthine 62.1 µM 0.442229801749177 0.341811003267891 no 1145 0.329161461324367 1612 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_3059 1327-0034 3 µM 0.440982017345892 0.342249166761307 no 1146 0.329613007800679 1516 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2450 5739737 12.93 µM 0.439802979883265 0.342663384792381 no 1147 0.33003990460956 1565 2262825
SGTC_2694 st077685 81.9 µM 0.438989450068886 0.342949303491172 no 1148 0.330334590350384 1509 2838096
SGTC_2300 7976697 71.57 µM 0.437651911936816 0.343419582741301 no 1149 0.330819316884726 1504 2236109
SGTC_160 3453-0671 289.699 µM 0.437635583475873 0.343425325338287 no 1150 0.330825236107175 1498 5322268
SGTC_1714 st033236 13.627 µM 0.435468325114814 0.344187854137538 no 1151 0.331611262777557 1678 2916566
SGTC_1324 1418-0026 34.4 µM 0.434608911767525 0.344490406084326 no 1152 0.33192316262804 1603 1372513
SGTC_3151 9099821 49.47 µM 0.434248141544516 0.344617443012025 no 1153 0.33205412874549 1525 17174189
SGTC_2799 7812892 81.82 µM 0.432069484837949 0.345384978844558 no 1154 0.332845456157392 1679 20205235
SGTC_2777 climbazole 1.536 µM 0.431894931846506 0.345446501039973 no 1155 0.332908889239365 1613 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_775 4577-0580 57.3 µM 0.431870490753587 0.34545511576823 no 1156 0.332917771587755 1631 2006902
SGTC_1782 st039423 80.636 µM 0.431761808268258 0.345493423947545 no 1157 0.332957269962506 1527 2068169
SGTC_948 3448-0295 75.3 µM 0.431445331908779 0.345604983897466 no 1158 0.333072297227567 1569 678569
SGTC_2350 9023895 38.85 µM 0.43133979286404 0.34564219007096 no 1159 0.333110660197579 1659 2997209
SGTC_1205 4161-2785 76 µM 0.430711941962701 0.345863560097251 no 1160 0.333338917274531 1502 3498106
SGTC_955 1216-0110 33 µM 0.428063425728943 0.346797963162248 no 1161 0.334302471905966 1516 3619719
SGTC_1793 st048256 72.231 µM 0.426125837824457 0.34748214004661 no 1162 0.33500807688203 1557 672022
SGTC_378 3970-0959 8.33 µM 0.424479311845205 0.348063931652432 no 1163 0.335608144961372 1609 6615653
SGTC_2686 alizarin 95.37 µM 0.419881052375769 0.349690594567802 no 1164 0.337286175060559 1532 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_286 k060-0067 22.9 µM 0.419780791114131 0.349726093502986 no 1165 0.337322799357114 1593 5985051
SGTC_63 0099-0242 26.702 µM 0.417204357730255 0.350638766535393 no 1166 0.338264469016846 1614 3898502 YLR359W ADE13
SGTC_3242 9133940 49.47 µM 0.416973624442894 0.350720543419349 no 1167 0.338348850019988 1632 17248444
SGTC_657 3534-0529 86.7 µM 0.416189646111127 0.350998454012413 no 1168 0.338635617782439 1694 1049549
SGTC_2872 9044037 25.97 µM 0.415950809593482 0.351083134444665 no 1169 0.33872299927799 1692 6465195
SGTC_1900 st060200 72.8 µM 0.414705549873695 0.351524765918126 no 1170 0.339178734534143 1592 688945
SGTC_2110 5483698 200 µM 0.414495753563385 0.351599189949013 no 1171 0.339255538150282 1619 2848765 YHR062C RPP1
SGTC_1640 st009078 66.4 µM 0.413907324089581 0.351807962255117 no 1172 0.339470989919632 1677 690618
SGTC_811 0416-0114 265 µM 0.413611394503464 0.351912973723679 no 1173 0.339579363528783 1603 6612453
SGTC_1156 4092-0367 4.88 µM 0.411841093074899 0.352541405978357 no 1174 0.34022794977739 1639 1357585
SGTC_799 1310-0557 151 µM 0.411245572839557 0.35275289793787 no 1175 0.3404462372478 1629 5354492
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.408633599651807 0.353681046111686 no 1176 0.341404284617722 1683 688751
SGTC_2016 5121758 140 µM 0.407923732148168 0.353933443712991 no 1177 0.3416648344279 1570 2795203
SGTC_2051 5263410 176 µM 0.40746493481867 0.354096605989434 no 1178 0.341833271578935 1646 227584
SGTC_817 1391-0715 46 µM 0.407111538431188 0.354222302755611 no 1179 0.341963034609631 1583 1353946
SGTC_772 k072-0172 35.3 µM 0.405860505928164 0.354667400172928 no 1180 0.342422549092938 1519 5861980
SGTC_1282 0886-0010 32.4 µM 0.405484704793689 0.35480114302135 no 1181 0.342560629536033 1747 2836211 YNL267W PIK1
SGTC_897 1000-0139 31.4 µM 0.40538273546977 0.354837435695668 no 1182 0.342598099709336 1739 6151020
SGTC_1388 3346-4487 254 µM 0.405140318890405 0.354923721304653 no 1183 0.342687185572616 1670 3345614
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.404574700485368 0.355125076105433 no 1184 0.342895079151515 1624 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3164 9100705 49.47 µM 0.403007579744461 0.355683167463907 no 1185 0.343471324216578 1697 17174235
SGTC_2132 5317594 122.667 µM 0.402289310326299 0.355939064893541 no 1186 0.343735560389203 1667 794577
SGTC_2788 5282734 71.43 µM 0.401418698140618 0.356249324415956 no 1187 0.344055942617318 1746 743706
SGTC_1270 0831-1170 17.3 µM 0.400995254941742 0.356400261025337 no 1188 0.344211808720154 1609 6764716
SGTC_1122 capsaicin 818.572 nM 0.399776915330983 0.356834664399155 no 1189 0.344660417476985 1703 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_416 estradiol valerate 100 µM 0.399242941215403 0.357025113361966 no 1190 0.344857102726043 1646 13791 A steroid.
SGTC_991 3996-0057 64.7 µM 0.399124947589 0.357067202165075 no 1191 0.344900570427413 1636 715343
SGTC_1479 0549-0158 134 µM 0.398878041196995 0.357155280300204 no 1192 0.344991534957698 1631 5440202
SGTC_2534 helenine 20.12 µM 0.39842305161795 0.357317607227743 no 1193 0.34515918434964 1624 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1615 st002656 86.5 µM 0.397439565186361 0.357668574524222 no 1194 0.34552167207457 1606 1584458
SGTC_2862 9027634 71.43 µM 0.395235854223109 0.358455428252961 no 1195 0.346334417171065 1569 5012562
SGTC_800 3448-7362 155 µM 0.39101371472758 0.359964656411815 no 1196 0.347893549207888 1693 15991913
SGTC_292 k038-0015 474 µM 0.390561257026449 0.360126520106138 no 1197 0.348060783923878 1677 46368540
SGTC_1899 st063254 59.6 µM 0.39007163272068 0.36030170815739 no 1198 0.34824178923406 1576 3093813
SGTC_3267 9137951 49.47 µM 0.389927386253541 0.360353325279143 no 1199 0.34829512115646 1674 16643986
SGTC_3270 9137563 49.47 µM 0.389766820817883 0.360410784970284 no 1200 0.348354490182433 1697 17015724
SGTC_2317 5986382 200 µM 0.388848758014409 0.360739381974095 no 1201 0.34869401497166 1766 877883
SGTC_2129 girgensonine 121.053 µM 0.38815481693312 0.360987828624798 no 1202 0.348950733866007 1714 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1773 st048542 73.5835 µM 0.387061574456701 0.361379353209049 no 1203 0.349355311917651 1560 3237138
SGTC_1700 st030840 7.9285 µM 0.386164896151256 0.361700590393845 no 1204 0.349687274980198 1769 5499307
SGTC_2213 7173844 200 µM 0.385943984229747 0.36177974760353 no 1205 0.349769077375577 1627 892728
SGTC_1637 st007924 17.4 µM 0.385370780545019 0.361985165652519 no 1206 0.349981363874239 1609 683336
SGTC_1616 st002734 56.1 µM 0.385049743846655 0.36210023241496 no 1207 0.350100280596097 1670 4026101
SGTC_86 0417-1630 471.922 µM 0.383959094634307 0.362491238628891 no 1208 0.35050438287274 1669 3634867
SGTC_787 4152-0075 138 µM 0.383741064641379 0.362569421295431 no 1209 0.350585186645649 1685 9566539
SGTC_1033 k072-0102 21.3 µM 0.38242092247122 0.363042929083065 no 1210 0.351074586863169 1761 5965931
SGTC_1463 k081-0032 34.1 µM 0.381815175270126 0.363260268260498 no 1211 0.351299230900073 1569 977755
SGTC_144 4161-2749 112.381 µM 0.379161734702844 0.364212828010684 no 1212 0.352283882514697 1645 797501 YMR168C CEP3
SGTC_862 0452-0056 10.2 µM 0.376693913404938 0.365099505835726 no 1213 0.353200543316496 1685 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1860 st056228 74.6 µM 0.376442155449183 0.365190002061054 no 1214 0.353294105647426 1621 688679
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.37477520839035 0.36578938749785 no 1215 0.353913826754962 1741 6710655
SGTC_1449 4112-4002 201 µM 0.374164636977357 0.366009013226127 no 1216 0.354140915946199 1609 2059539
SGTC_1249 0481-0015 10.2 µM 0.37363379068308 0.366199997101482 no 1217 0.354338395224797 1623 4227577
SGTC_2196 6573537 42.6665 µM 0.373461589632348 0.366261957419672 no 1218 0.354402463878409 1757 2903087
SGTC_2945 9067681 61.76 µM 0.372578998088431 0.366579580759198 no 1219 0.354730903126976 1696 16456930
SGTC_313 3474-0040 5.03 µM 0.371470615079743 0.366978590421875 no 1220 0.355143519250454 1636 1043375 YIL048W NEO1
SGTC_1704 st028805 70.8 µM 0.370401101328975 0.367363743719889 no 1221 0.355541826665151 1657 2876101
SGTC_2456 5770359 74.46 µM 0.368963244059362 0.367881755187025 no 1222 0.356077560904069 1759 3118787
SGTC_2867 9039098 71.43 µM 0.368048593389011 0.368211398122338 no 1223 0.356418500506268 1649 6463460
SGTC_2877 9040724 71.43 µM 0.367353500396688 0.368461976706466 no 1224 0.356677675907666 1806 6463895
SGTC_1244 0416-0015 52.5 µM 0.365782155416959 0.369028647122879 no 1225 0.357263818210738 1674 96201
SGTC_1811 st050069 61.5 µM 0.365774248076233 0.369031499449601 no 1226 0.357266768656174 1757 3877702
SGTC_36 0335-0881 14.2 µM 0.364888648659591 0.369350997440426 no 1227 0.357597264018724 1697 23828853
SGTC_1149 3909-7961 23.3 µM 0.364491396749719 0.36949434347896 no 1228 0.357745548510137 1628 735261
SGTC_1642 st009582 77.7 µM 0.363002164705315 0.370031885540612 no 1229 0.358301633635665 1803 6739311
SGTC_511 blebbistatin 171 µM 0.362480959375663 0.370220075975287 no 1230 0.35849632485394 1778 3476986 A myosin inhibitor.
SGTC_126 0417-1624 672.48 µM 0.361876151578252 0.370438491509699 no 1231 0.358722291073665 1834 41912 YDL195W SEC31
SGTC_350 k064-0020 19.8 µM 0.361470136242161 0.37058514013598 no 1232 0.358874012885972 1800 2790705
SGTC_959 1222-0044 107 µM 0.361337168681952 0.370633170760678 no 1233 0.35892370570103 1828 6083612
SGTC_587 k089-0003 57 µM 0.359231481541678 0.371394056717665 no 1234 0.359710963710451 1763 9659696
SGTC_515 4092-1064 102 µM 0.358932320137216 0.371502198974431 no 1235 0.359822860262246 1816 717353
SGTC_2634 4'-methoxyflavone 100 µM 0.357515932646903 0.372014338878636 no 1236 0.36035280038262 1678 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2341 7987486 176.74 µM 0.357417346571925 0.372049994248803 no 1237 0.360389696277369 1835 1258686
SGTC_3200 9114385 49.47 µM 0.355724782341844 0.372662310446208 no 1238 0.361023341907079 1620 17018030 YLR208W SEC13
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.355277886732428 0.372824036927549 no 1239 0.36119071005948 1628 6708514
SGTC_690 glyoxal 20.3 µM 0.354219160771219 0.37320726733526 no 1240 0.361587322549864 1680 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_407 eburnamonine 100 µM 0.353101918665766 0.373611815080952 no 1241 0.362006017266459 1649 3195
SGTC_2182 6325192 200 µM 0.352185063662974 0.3739439077586 no 1242 0.362349738877213 1724 736248
SGTC_1871 st057448 67.3 µM 0.349363844151443 0.374966363541529 no 1243 0.363408086726638 1790 691747
SGTC_74 000s-0487 160.283 µM 0.34720560226357 0.375749139577476 no 1244 0.364218431173645 1683 677548
SGTC_1300 1094-0077 113 µM 0.347092217311086 0.37579027751238 no 1245 0.3642610200871 1671 5532636
SGTC_1274 0865-0114 173 µM 0.347029653301458 0.375812977373687 no 1246 0.364284520688374 1721 870624
SGTC_3219 9131112 49.47 µM 0.346452039209274 0.376022571186457 no 1247 0.364501511027511 1718 17612988 YMR079W SEC14
SGTC_1750 st081859 2.357 µM 0.345097714144787 0.376514146690903 no 1248 0.365010455932319 1749 5291695
SGTC_3113 9123498 49.47 µM 0.345090709616096 0.376516689626098 no 1249 0.365013088799288 1732 8897275
SGTC_340 k038-0059 454 µM 0.343899719368267 0.376949146448955 no 1250 0.365460851461149 1754 23733424
SGTC_3198 9112019 49.47 µM 0.343056471858002 0.377255428874553 no 1251 0.365777988303785 1732 45595555
SGTC_3016 9080866 49.47 µM 0.341046098799308 0.377985943182486 no 1252 0.366534439003639 1667 17066299
SGTC_2858 9025781 8.96 µM 0.340828838382098 0.37806491582704 no 1253 0.366616219517604 1799 4894980 YPL153C RAD53
SGTC_2423 st077119 87.2 µM 0.340156930096759 0.37830918202916 no 1254 0.366869175527357 1691 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3158 9100007 49.47 µM 0.339500961602446 0.378547700389947 no 1255 0.367116186400269 1666 19297233
SGTC_2584 androsterone 48.74 µM 0.338755916140137 0.378818664377556 no 1256 0.367396806735915 1747 2754130 A steroid.
SGTC_1485 3909-9022 254 µM 0.337744873840015 0.37918646343685 no 1257 0.367777727666475 1731 714516
SGTC_654 1124-0271 80.9 µM 0.337595958491379 0.3792406454209 no 1258 0.367833844106913 1660 5403748
SGTC_1686 st019653 115.5 µM 0.33729655850279 0.379349587544866 no 1259 0.367946676887927 1830 97252
SGTC_2401 5128683 200 µM 0.335216485064438 0.380106724114493 no 1260 0.368730893726288 1624 708373
SGTC_246 cycloheximide 667 µM 0.335140543223953 0.380134375288743 no 1261 0.368759535232702 1699 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_3351 9150312 21.596 µM 0.334147471801724 0.380496018743166 no 1262 0.369134139698553 1731 4904905
SGTC_1226 3909-7979 35.4 µM 0.333193131498747 0.380843656059592 no 1263 0.369494251238817 1838 6615510
SGTC_1121 fusaric acid 630.51 nM 0.331303333083901 0.381532336141807 no 1264 0.37020768695331 1687 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2181 6316240 54.2555 µM 0.330718463258257 0.381745550459183 no 1265 0.370428577352879 1665 12779990
SGTC_3160 9100216 49.47 µM 0.33027819437875 0.381906074171132 no 1266 0.370594883860456 1769 17191039
SGTC_1157 4092-0394 27.6 µM 0.32963065306061 0.382142207094538 no 1267 0.370839529083947 1812 3659885
SGTC_575 k072-0246 11.9 µM 0.329114432535564 0.382330483888316 no 1268 0.371034597894164 1754 6796779
SGTC_1108 betulinic acid 729.144 nM 0.328335386803918 0.382614671386008 no 1269 0.37132904552428 1720 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2730 imipramine 71.33 µM 0.328156332361973 0.382679997459938 no 1270 0.37139673147921 1820 3696 A tricyclic antidepressant.
SGTC_4 0960-0234 25.671 µM 0.328141833182814 0.382685287474545 no 1271 0.371402212616393 1728 6821112
SGTC_1114 scopoletin 1.73284 µM 0.328080869438931 0.382707530290107 no 1272 0.371425259078321 1848 5280460 A coumarin with genotoxic properties.
SGTC_2640 pentamidine 10.38 µM 0.325720580694508 0.383568985913902 no 1273 0.372317885772035 1876 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2879 9041815 71.43 µM 0.323546863989245 0.384362856196176 no 1274 0.373140561007883 1760 4942971
SGTC_2497 7-hydroxyflavone 100 µM 0.322663710802435 0.384685534324549 no 1275 0.373474968937658 1834 5281894
SGTC_18 0111-0177 500 nM 0.322251231995552 0.384836269302945 no 1276 0.373631187626513 1762 721752
SGTC_2580 diallyl disulphide 81.36 µM 0.319618810603931 0.385798662389597 no 1277 0.374628656502921 1751 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1075 aripiprazole 15.2 µM 0.318891760897203 0.386064590402175 no 1278 0.374904296133391 1730 60795 An atypical antipschotic. YIL048W NEO1
SGTC_627 1391-0720 175 µM 0.318572997767991 0.386181199108456 no 1279 0.375025166011991 1761 997839
SGTC_2728 chlorpromazine 9.18 µM 0.318431466536635 0.386232976817875 no 1280 0.375078836326119 1786 2726 A thorazine and dopamine antagonist.
SGTC_483 fpl-64176 144 µM 0.317205903188823 0.386681420896672 no 1281 0.375543685476579 1774 3423
SGTC_98 0074-0023 107.663 µM 0.317039927089298 0.386742164616768 no 1282 0.375606653170083 1703 3563821
SGTC_1152 3909-8331 15.9 µM 0.316392682495815 0.386979068858335 no 1283 0.375852235220202 1737 16001939
SGTC_2925 9010536 32.5 µM 0.316036645796925 0.387109403246674 no 1284 0.375987346592382 1814 2994177
SGTC_3041 9091929 49.47 µM 0.315521437685848 0.387298028062295 no 1285 0.376182888393582 1798 25236887
SGTC_1962 st076595 64.5 µM 0.315219409565805 0.387408617110441 no 1286 0.37629753476242 1754 279619
SGTC_3350 9150499 3.57 µM 0.313956010899873 0.387871315558838 no 1287 0.376777224452424 1749 4910996 YPR165W RHO1
SGTC_2090 5301565 104.445 µM 0.313727960652721 0.387954852100956 no 1288 0.376863831314895 1761 2056344
SGTC_2878 9043973 25.97 µM 0.312810491116941 0.388290980535532 no 1289 0.37721232217626 1849 6465167
SGTC_2072 5231554 129 µM 0.31158373346824 0.388740551933153 no 1290 0.377678449023574 1924 789545
SGTC_708 3448-5400 146 µM 0.311479216561071 0.38877886127243 no 1291 0.377718170197184 1830 3462195
SGTC_1629 st005085 44.9 µM 0.308397219162197 0.389909012800621 no 1292 0.378890048856179 1686 24207091
SGTC_21 0849-0113 22.993 µM 0.307858325076006 0.390106718231731 no 1293 0.379095069186167 1734 1560156
SGTC_285 1486-1325 46 µM 0.307614135261364 0.390196314126908 no 1294 0.379187981531239 1839 22310230
SGTC_988 1497-1057 103 µM 0.307143892988591 0.390368867551699 no 1295 0.379366924754165 1938 3533044
SGTC_1184 1269-1718 139 µM 0.306183396457263 0.390721384792973 no 1296 0.379732506718749 1876 5403821
SGTC_3299 9121982 43.1275 µM 0.305182807152508 0.391088712242427 no 1297 0.380113463052804 1735 17594604 YPL160W CDC60
SGTC_2311 7694451 200 µM 0.30464592827838 0.391285846521944 no 1298 0.380317917986662 1828 2163142
SGTC_158 k038-0087 26.446 µM 0.304059748494771 0.391501115287054 no 1299 0.380541185947718 1787 X158
SGTC_629 3448-6466 76.7 µM 0.302471196812005 0.392084662166527 no 1300 0.381146443689404 1781 573744
SGTC_2773 thioridazine 9.09 µM 0.302149049405947 0.392203031133417 no 1301 0.381269221337598 1818 5452 An antipsychotic.
SGTC_636 0kpi-0074 126 µM 0.301744393349297 0.392351730988593 no 1302 0.381423461828377 1782 616434
SGTC_3035 9091303 49.47 µM 0.301454997401449 0.392458085599058 no 1303 0.381533780819418 1782 25237002
SGTC_668 1682-0499 62.6 µM 0.300805600522029 0.39269677176565 no 1304 0.381781368745711 1767 682214
SGTC_1664 st014217 9.02 µM 0.299215710212205 0.393281306984473 no 1305 0.382387731541338 1855 3982782
SGTC_2353 9059630 146.67 µM 0.298901789554956 0.393396750783576 no 1306 0.382507490813805 1858 4779114
SGTC_35 0133-0054 64.071 µM 0.298048858528799 0.393710462051269 no 1307 0.382832936753369 1697 99677
SGTC_1265 0819-1001 68.8 µM 0.296399716634962 0.394317218210029 no 1308 0.383462420851589 1776 3106768
SGTC_68 0986-0284 82.829 µM 0.29613525062908 0.394414545070728 no 1309 0.383563397266522 1648 423278 YIL048W NEO1
SGTC_923 1900-2434 73.3 µM 0.295797011919998 0.394539030832487 no 1310 0.383692552542869 1748 5910570
SGTC_2060 5238662 140 µM 0.295569950743979 0.394622604730528 no 1311 0.38377926231447 1764 790130
SGTC_3051 9093778 49.47 µM 0.294007319403993 0.395197890295021 no 1312 0.384376155178396 1829 17217378
SGTC_2291 7917025 104.35 µM 0.292325051621226 0.39581747562986 no 1313 0.385019053246187 1733 2964612
SGTC_591 4299-0174 154 µM 0.29194493115891 0.395957511906999 no 1314 0.385164364532467 1849 5509088
SGTC_293 4049-0273 38.5 µM 0.290219409059422 0.396593362373606 no 1315 0.38582419430966 1806 1380311
SGTC_3077 9117319 49.47 µM 0.288094343474705 0.39737682145404 no 1316 0.386637261205686 1833 17154678
SGTC_2246 7293507 91.5585 µM 0.287900642934653 0.397448254694285 no 1317 0.386711397376312 1946 887656
SGTC_720 r052-1644 49.9 µM 0.287812216273576 0.397480865984066 no 1318 0.386745242817876 1797 1422863 YOR257W CDC31
SGTC_1908 st060353 56.5 µM 0.286279485588457 0.398046242706331 no 1319 0.387332034517969 1970 4227716
SGTC_271 rotenone 740 µM 0.285933587956199 0.398173863253473 no 1320 0.387464493874841 1883 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2984 9022109 38.96 µM 0.285184465544921 0.398450292793715 no 1321 0.387751410557575 1856 6459207
SGTC_578 3460-0051 92 µM 0.2850903416784 0.398485028530652 no 1322 0.387787464688313 1942 2876744
SGTC_2335 9018011 154.17 µM 0.284012465837091 0.398882868146477 no 1323 0.388200413747266 1911 6458208
SGTC_2053 5265679 138 µM 0.283035572736693 0.399243526226732 no 1324 0.388574784163628 1764 764595
SGTC_1080 nisoldipine 24.4 µM 0.281755337793714 0.399716304932258 no 1325 0.389065559616296 1812 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_605 1315-0399 119 µM 0.281149351972765 0.399940141112092 no 1326 0.389297924829672 1860 24020461
SGTC_863 0466-0191 129 µM 0.280735516938179 0.400093020441448 no 1327 0.389456632595717 1903 765160 YPR165W RHO1
SGTC_616 4092-0450 108 µM 0.279987644559746 0.400369338987082 no 1328 0.389743492077025 1844 787165
SGTC_1358 1509-0022 2.48 µM 0.279789574312703 0.400442528926916 no 1329 0.389819475439328 1853 3258434
SGTC_983 1491-0821 12.2 µM 0.277592024079163 0.40125479084915 no 1330 0.390662777735257 1910 46495113
SGTC_1765 st044815 90.4 µM 0.276987780776992 0.40147820717968 no 1331 0.390894744369348 1747 645695
SGTC_1273 0849-0096 14.1 µM 0.274881966986976 0.402257073951264 no 1332 0.391703460962966 1785 5286025
SGTC_1848 st056003 16.4 µM 0.274874425798063 0.402259863872407 no 1333 0.391706357924109 2007 146492
SGTC_3317 9138495 8.753 µM 0.274152569127211 0.402526943358444 no 1334 0.391983688225313 1827 17020139
SGTC_1437 4092-1038 11.6 µM 0.273382388591936 0.402811952344511 no 1335 0.392279644604677 1823 3977136
SGTC_1161 k007-0610 110 µM 0.272057140489387 0.403302487562373 no 1336 0.392789041940333 1941 5843850
SGTC_1128 3448-9350 235 µM 0.270459505784534 0.40389404784466 no 1337 0.393403383054441 1779 619386
SGTC_658 3253-0951 102 µM 0.268747747673066 0.404528108871676 no 1338 0.394061902830358 1858 1184878
SGTC_10 0279-0212 42.575 µM 0.268300049835815 0.404693984349559 no 1339 0.394234183931437 1822 39851 YBR002C RER2
SGTC_84 0443-0269 128.823 µM 0.267923834679519 0.404833388192953 no 1340 0.394378973387268 1908 6150058
SGTC_2996 9066192 71.4286 µM 0.266503011193154 0.405359973011899 no 1341 0.394925920321023 1744 6472854
SGTC_374 0880-0231 82.3 µM 0.265113105256927 0.405875265004728 no 1342 0.395461165961251 1899 6833587
SGTC_1448 4255-0083 152 µM 0.263075800524527 0.406630867381486 no 1343 0.396246077772846 1948 5399660
SGTC_1807 st050092 58.9 µM 0.263065818659171 0.406634570347393 no 1344 0.396249924521645 1845 5008496
SGTC_6 0844-0013 19.835 µM 0.262922763159795 0.406687640467236 no 1345 0.39630505546423 1923 1584900
SGTC_3321 9137793 26.8275 µM 0.262831526354355 0.406721488003814 no 1346 0.396340217524003 1909 4904192
SGTC_9 0092-0002 10.449 µM 0.262780445165466 0.406740438691146 no 1347 0.396359904243664 1865 759368
SGTC_1767 st044992 70.3 µM 0.262222534474102 0.40694743302958 no 1348 0.396574940540613 1791 9600693
SGTC_2006 4011487 200 µM 0.261918639955881 0.407060193995356 no 1349 0.396692084268988 1930 45595294
SGTC_3078 9116413 49.47 µM 0.26106406972485 0.407377326087528 no 1350 0.397021549643315 1848 17177322
SGTC_3286 9117135 37.221 µM 0.26045990036369 0.407601570752012 no 1351 0.397254521487091 1769 3438150
SGTC_1236 0330-0013 258 µM 0.259808052163236 0.407843545942375 no 1352 0.397505919733522 1824 4617066
SGTC_2305 7443522 69.23 µM 0.256846775924788 0.40894325453001 no 1353 0.398648529524635 1887 5415886
SGTC_2448 5185112 27.17 µM 0.252792936322056 0.410449862124735 no 1354 0.400214113229871 1852 5718189
SGTC_854 0422-0053 192 µM 0.251686749281695 0.410861206631784 no 1355 0.400641599953451 1886 3596728
SGTC_3000 9075062 71.4286 µM 0.251684172339665 0.410862165002952 no 1356 0.400642595953589 1846 17057871
SGTC_453 enantio-paf c16 10 µM 0.250841657934471 0.411175526705307 no 1357 0.400968266303464 1908 13871343 A lipid and platelet activating factor
SGTC_1690 st023502 41.2 µM 0.248856441594905 0.411914124551757 no 1358 0.401735915008642 1976 24207482
SGTC_2093 5331342 194.4 µM 0.24817494839 0.412167745557164 no 1359 0.4019995242087 1982 33839
SGTC_473 2-arachidonoylglycerol 10 µM 0.247588956747604 0.41238585453226 no 1360 0.402226227992809 1804 5282280 An endocannabinoid.
SGTC_3033 9090887 49.47 µM 0.247464624259957 0.412432135178544 no 1361 0.402274332988843 1815 19325384
SGTC_442 cape 100 µM 0.247342020709827 0.412477773449664 no 1362 0.402321770497816 1989 5281787
SGTC_2288 7946289 167.31 µM 0.246134398561475 0.412927365063866 no 1363 0.402789097894756 1970 1246052
SGTC_122 0236-0016 402.397 µM 0.246029924169366 0.412966265728519 no 1364 0.402829534087385 1873 6808838
SGTC_2900 5328528 85.29 µM 0.245566960064052 0.413138659030066 no 1365 0.403008734095547 1848 795359
SGTC_849 0386-0493 241 µM 0.242230180188567 0.414381664583563 no 1366 0.404300905428247 1879 726119
SGTC_447 ml7 120 µM 0.240418272262108 0.415056990428651 no 1367 0.405003007165922 1995 4216 Selective myosin light chain kinase inhibitor.
SGTC_542 3381-0244 89.3 µM 0.238571953896082 0.415745399837953 no 1368 0.405718757378615 1996 1112843
SGTC_3108 9121785 49.47 µM 0.238176158601455 0.415893007910593 no 1369 0.405872233886179 2006 17140271
SGTC_1674 st016616 23.6 µM 0.237757266568296 0.416049242616063 no 1370 0.406034682315121 1774 625830
SGTC_2474 5321570 43.32 µM 0.23546226584036 0.416905446856166 no 1371 0.406924981535209 1987 2841384
SGTC_194 1486-1323 56.904 µM 0.235112917704583 0.417035814109187 no 1372 0.407060546407127 1847 5178754
SGTC_2136 5328288 199.296 µM 0.23499942273662 0.417078169318268 no 1373 0.407104590633129 1846 262395
SGTC_1600 coumarin 106 71.1 µM 0.234313164307148 0.417334294720339 no 1374 0.407370933362666 1917 100336 A hepatotoxic, DNA x-linker.
SGTC_383 2324-0395 7.37 µM 0.234259899927393 0.417354175523005 no 1375 0.407391607513906 1939 3146421
SGTC_750 4073-0104 132 µM 0.232185871789599 0.41812846538123 no 1376 0.408196825310569 1965 22330957
SGTC_1742 st038235 28.8875 µM 0.23179101310714 0.418275912687043 no 1377 0.408350168745234 1874 564103 YBR002C RER2
SGTC_2330 7979373 200 µM 0.229036503763657 0.419304814232322 no 1378 0.409420272111085 1781 1863007
SGTC_3147 9097027 49.47 µM 0.228677618269418 0.419438910789019 no 1379 0.409559745952171 1935 25236841
SGTC_2860 9025725 38.96 µM 0.225871663564861 0.420487669264203 no 1380 0.410650618756434 1813 40546248
SGTC_613 3914-0030 117 µM 0.225397504320564 0.420664947819197 no 1381 0.410835026480698 1942 1145395
SGTC_2142 5622915 118.518 µM 0.225229732728095 0.420727678081538 no 1382 0.410900280121217 1894 5322196
SGTC_1829 berberine 14.4 µM 0.225004657746594 0.420811837400982 no 1383 0.410987825404857 2007 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1371 2421-0008 32.7 µM 0.224983949364457 0.420819580795075 no 1384 0.410995880370899 1869 2827552
SGTC_3134 9127454 49.47 µM 0.2243792906248 0.421045691667702 no 1385 0.411231091790919 2014 24262820
SGTC_528 3492-0019 172 µM 0.22414797305319 0.421132199282212 no 1386 0.411321082453123 1986 2869262
SGTC_3014 9081533 49.47 µM 0.222798073398343 0.421637107473206 no 1387 0.411846333765098 2035 21367265
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.221820861584016 0.422002698245382 no 1388 0.412226669398466 1984 91467 include heat shock
SGTC_3284 9108171 64.8615 µM 0.220768758940594 0.422396382032015 no 1389 0.41263624507346 1922 8687505
SGTC_2366 9070441 60.58 µM 0.220593726235946 0.422461884637038 no 1390 0.41270439323631 1867 6837235
SGTC_1145 3546-0597 10.2 µM 0.220067196238693 0.42265894122722 no 1391 0.412909411077289 1918 875334
SGTC_1026 k007-1105 30.6 µM 0.218462343403375 0.423259684958038 no 1392 0.413534447662879 1883 7066794
SGTC_236 1509-0011 5.31 µM 0.217757314118439 0.423523654707646 no 1393 0.41380910240872 1991 3107280
SGTC_677 0929-0063 136 µM 0.217040372818585 0.423792119631599 no 1394 0.414088440902548 1964 1539583
SGTC_1839 st053978 48 µM 0.216018426080525 0.424174857623846 no 1395 0.414486692352229 2041 3788398
SGTC_865 0488-0499 301 µM 0.215300345176328 0.424443835036861 no 1396 0.414766580262803 2069 9634651
SGTC_879 0831-1030 162 µM 0.214903210794189 0.424592608018252 no 1397 0.414921390763149 1880 1549252
SGTC_380 3970-0968 6 µM 0.214847445100276 0.424613499612434 no 1398 0.414943130344823 1902 2891601
SGTC_3098 9119039 49.47 µM 0.213633558998728 0.425068312150875 no 1399 0.415416413600411 1991 17161528
SGTC_3303 9125618 40.5795 µM 0.212201164656475 0.425605122482538 no 1400 0.415975049082952 1978 22695467
SGTC_1104 tacrolimus 29.8 µM 0.209685308565553 0.426548308938278 no 1401 0.416956646349676 1937 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2381 9035592 200 µM 0.209480672101428 0.426625045050371 no 1402 0.417036511054187 1863 4749657
SGTC_2687 chenodiol 100 µM 0.207814793201658 0.427249831866576 no 1403 0.417686790735246 1952 5702181 A cholesterol synthesis inhibitor.
SGTC_1191 1487-1166 10.6 µM 0.207093304115759 0.427520482622594 no 1404 0.417968495645642 2005 3955771
SGTC_2141 5621638 7.665 µM 0.206538800963957 0.427728515470096 no 1405 0.418185029629741 2034 2856238
SGTC_262 fenpropimorph 62.5 µM 0.202567522864876 0.429219003035889 no 1406 0.419736538343665 1951 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_825 1988-2224 89.6 µM 0.202082945556902 0.429400942607758 no 1407 0.419925940144384 1938 1180859
SGTC_1426 4048-4480 71.7 µM 0.201416112757557 0.429651336404653 no 1408 0.420186608609587 2026 14224343
SGTC_1995 st072814 61.1 µM 0.200485603116739 0.430000787376915 no 1409 0.420550408238281 1898 5769371
SGTC_1357 1503-1303 39.5 µM 0.200399407434605 0.430033160766671 no 1410 0.420584111443821 1955 292895
SGTC_920 mycophenolic acid 780.421 nM 0.200363327528193 0.430046711804059 no 1411 0.420598219150511 1900 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3089 9117425 49.47 µM 0.200165713366883 0.430120933992367 no 1412 0.420675490633607 1885 9401657
SGTC_2915 7971052 15.16 µM 0.198958369008047 0.430574455739189 no 1413 0.421147655107338 2045 5741558
SGTC_3326 9140064 16.379 µM 0.198888130933789 0.43060084249813 no 1414 0.421175127092643 1902 1868434
SGTC_2927 9011802 47.9 µM 0.198225564590061 0.430849768004937 no 1415 0.421434293338752 1872 43912568
SGTC_2338 7999974 200 µM 0.197958828355745 0.430949988301471 no 1416 0.42153863821059 2077 315925
SGTC_530 4358-1714 28 µM 0.197796594241678 0.431010946390836 no 1417 0.421602105466123 2000 1564641
SGTC_2863 9028737 58.44 µM 0.197693417966477 0.431049714854317 no 1418 0.421642469892337 2097 6460917
SGTC_2361 9034121 116 µM 0.196896340990008 0.431349238722901 no 1419 0.421954328549583 1939 6496917
SGTC_1348 1493-0373 93.8 µM 0.196858029507928 0.431363636324888 no 1420 0.421969319261416 1988 3010129
SGTC_67 0335-0847 266 µM 0.196388319949833 0.431540162386585 no 1421 0.422153118793425 2094 4552207 YOR254C SEC63
SGTC_3263 9137018 49.47 µM 0.196230960093085 0.431599304365572 no 1422 0.42221469822995 1865 43844957
SGTC_2843 9000894 45.46 µM 0.194839034492516 0.432122510979651 no 1423 0.422759481373192 2006 2242070
SGTC_2581 avocatin a 64 µM 0.19450753646991 0.432247134336827 no 1424 0.422889247585289 1954 6710728 A skin care supplement.
SGTC_1230 0170-0365 3.77 µM 0.193981548963981 0.432444887894598 no 1425 0.423095164640683 2071 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1655 st012546 55.1 µM 0.193744251075573 0.432534109438087 no 1426 0.423188070463067 1996 720985 YLR208W SEC13
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.192532032456503 0.432989944637621 no 1427 0.423662739485405 1922 5282362
SGTC_1632 st005650 90 µM 0.190758859757494 0.433656878006871 no 1428 0.424357260943147 1970 2759605
SGTC_3061 glucosamine 200 µM 0.190614068861634 0.433711345753119 no 1429 0.424413983468602 2082 91431 and experimental redox chemotherapeutic
SGTC_2658 polymyxin b sulfate 77.05 µM 0.190089887678157 0.433908543862966 no 1430 0.424619347036955 1978 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2993 9054257 71.4286 µM 0.189982600762592 0.433948907465366 no 1431 0.424661382401583 2009 6470217 YGL055W OLE1
SGTC_2116 5511452 16.8835 µM 0.189671213946558 0.43406606165764 no 1432 0.424783389625609 2003 870744
SGTC_1949 st076024 69.1 µM 0.189502781199721 0.434129434135784 no 1433 0.424849387754559 1869 2921930
SGTC_3109 9122853 49.47 µM 0.186540980073191 0.435244080964192 no 1434 0.426010272669945 2020 1234709
SGTC_1523 st012844 44.7 µM 0.186169864936091 0.43538378323131 no 1435 0.426155777552999 1974 4274103
SGTC_2220 6782180 200 µM 0.185343281053072 0.435694970728026 no 1436 0.426479896345161 2070 833803
SGTC_1316 1272-0050 65.9 µM 0.184021152117778 0.436192800853806 no 1437 0.426998430647326 2000 7340392
SGTC_202 3594-0513 34.79 µM 0.183770665293787 0.436287129762706 no 1438 0.427096684939098 2080 708429
SGTC_251 melphalan 456.522 µM 0.183184891527441 0.436507735942376 no 1439 0.427326474297481 2026 460612 A DNA alkylator.
SGTC_480 am 92016 50 µM 0.181319842986923 0.4372102564752 no 1440 0.428058265860045 1940 2129 K+ channel blocker.
SGTC_2455 5377712 9.75 µM 0.18060502553038 0.437479564247741 no 1441 0.428338805476313 1899 2243908
SGTC_1971 st069429 63.5 µM 0.180533016917336 0.437506695130579 no 1442 0.42836706822448 2089 1246522 YGL099W LSG1
SGTC_1057 3448-5381 134 µM 0.179880850173177 0.437752427151634 no 1443 0.428623054658767 2070 5497911
SGTC_2716 st080858 38.6235 µM 0.17940973058061 0.437929956771489 no 1444 0.428807995725566 2072 5296050
SGTC_1275 0867-0008 21.1 µM 0.178869385567094 0.438133587637934 no 1445 0.429020130926964 2010 3422836
SGTC_903 1134-0042 114 µM 0.178743869883924 0.438180890999044 no 1446 0.429069410333545 1955 701009
SGTC_691 1548-0686 185 µM 0.176524629865977 0.439017405943301 no 1447 0.429940900330294 1945 46495133
SGTC_1107 amlodipine 47 µM 0.176487388091406 0.439031446102091 no 1448 0.429955528006791 2033 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1298 1079-1278 263 µM 0.175625245483776 0.439356495498298 no 1449 0.430294183795334 1980 2840950
SGTC_484 loperamide 105 µM 0.175037435114271 0.439578138215766 no 1450 0.430525109332457 2031 3955 An opioid-receptor agonist.
SGTC_2623 humulene 100 µM 0.174849042992824 0.439649178302601 no 1451 0.430599125565897 1963 6187145 An anti-inflammatory.
SGTC_673 1082-0474 110 µM 0.173751722720233 0.440063001291025 no 1452 0.431030293424422 1986 3098046
SGTC_867 0518-0118 155 µM 0.173450731124404 0.440176523135382 no 1453 0.431148575839568 2143 6848158
SGTC_3258 9138477 49.47 µM 0.173401749414164 0.440194997518995 no 1454 0.431167825051174 2064 4970355
SGTC_1326 1431-2094 10.8 µM 0.173261730079799 0.440247809191949 no 1455 0.431222851834467 1924 616278
SGTC_763 3453-1109 128 µM 0.173040122480161 0.440331396021484 no 1456 0.431309945059047 2110 1560353
SGTC_888 0916-0002 6.97 µM 0.172454446224748 0.440552316494987 no 1457 0.431540135693842 2068 2802138 YIL048W NEO1
SGTC_609 0986-0026 86.3 µM 0.171741525185838 0.44082125940358 no 1458 0.431820369214327 2019 2848610
SGTC_87 0100-0052 35.5 µM 0.171300432319232 0.440987671310197 no 1459 0.431993770273225 2027 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1579 chlormadinone acetate 49.4 µM 0.171136442243876 0.441049542802506 no 1460 0.432058240885668 2108 45114258 A steroidal progestin.
SGTC_2024 5144227 134 µM 0.170982652448666 0.441107567158666 no 1461 0.432118703031792 2056 3475211
SGTC_2886 9058944 51.95 µM 0.169451047977287 0.441685505001768 no 1462 0.432720936760034 2088 4949929
SGTC_1359 1582-0056 520 nM 0.168903506739607 0.441892145197547 no 1463 0.432936270425579 2069 3661189
SGTC_193 1273-0060 1.558 µM 0.167611555548891 0.442379785753198 no 1464 0.433444439901708 2106 2847393 YHR072W ERG7
SGTC_1777 st045864 34.765 µM 0.167010333293322 0.442606743922142 no 1465 0.433680959163983 2111 4691462
SGTC_1919 st067113 52.3 µM 0.164020445409633 0.443735688836601 no 1466 0.43485752433552 2021 1268243
SGTC_555 4296-0685 37 µM 0.16224974657698 0.444404498905817 no 1467 0.435554593319248 2109 2908540 YHR072W ERG7
SGTC_1063 disulfiram 1.84 µM 0.162006147361057 0.444496521117064 no 1468 0.43565050646459 2101 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1504 k297-0033 30 µM 0.16164411810348 0.444633287069946 no 1469 0.435793056463153 1948 4388117
SGTC_2342 7990637 118.86 µM 0.160834123211955 0.444939307522993 no 1470 0.436112024325923 2022 2033102 YER133W GLC7
SGTC_1190 1486-1332 13 µM 0.159151105210022 0.445575265563235 no 1471 0.436774912575935 2099 4150046
SGTC_748 act1.228 77.9 µM 0.157702746508791 0.446122665645613 no 1472 0.437345518088812 2006 4421505 YNR035C ARC35
SGTC_3019 9081971 49.47 µM 0.155611030188031 0.446913400590253 no 1473 0.43816981501531 2129 16451803
SGTC_347 4534-1311 26.2 µM 0.155466513608413 0.446968040261476 no 1474 0.438226775601025 2101 2862016
SGTC_1409 3909-8004 61.9 µM 0.154266602817162 0.447421748313123 no 1475 0.438699764573969 2041 2119279
SGTC_3202 9113761 49.47 µM 0.15390041508476 0.447560224273363 no 1476 0.438844128406729 2123 4798415
SGTC_780 0109-0199 192 µM 0.153548748189028 0.447693215114234 no 1477 0.438982775283647 2157 610414
SGTC_430 0958-0115 16.4 µM 0.153241483050983 0.447809419233877 no 1478 0.439103922618576 1973 6833180
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.153100342948822 0.447862798289223 no 1479 0.439159572716151 2035 6708784 An antioxidant flavonoid
SGTC_133 0724-0033 378.92 µM 0.148445484987184 0.44962378458851 no 1480 0.440995602925385 2153 280309
SGTC_3072 9116419 49.47 µM 0.147633197720403 0.449931184897025 no 1481 0.441316127090288 2030 17170162
SGTC_2776 terbinafine 19.92 µM 0.147224174021107 0.450085986362723 no 1482 0.441477540195577 2153 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2968 9090663 33.37 µM 0.146176070083531 0.450482692427852 no 1483 0.441891197968343 2004 25236811
SGTC_3130 9127414 49.47 µM 0.146136223719631 0.450497775206859 no 1484 0.441906925484716 2193 1494646
SGTC_889 0919-1524 82.7 µM 0.14576389932723 0.450638712133877 no 1485 0.442053887807713 2003 3905452
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.144108002311026 0.451265598320645 no 1486 0.442707592876611 2115 16725076
SGTC_184 1494-0393 24.714 µM 0.143961139299713 0.451321203318102 no 1487 0.442765578131002 2030 3090647
SGTC_1178 0988-0033 191 µM 0.143387055612752 0.451538570959692 no 1488 0.442992252731707 2094 5392207
SGTC_2855 9016525 58.44 µM 0.14313820603907 0.451632798404292 no 1489 0.443090515771818 2120 43811474
SGTC_880 0833-0487 87.2 µM 0.142452396316536 0.451892495868783 no 1490 0.443361339027602 2099 76075
SGTC_601 0986-0029 62.9 µM 0.14225738919571 0.451966343518546 no 1491 0.443438351322449 2072 24747981
SGTC_671 0560-0003 407 µM 0.140199468933614 0.452745762420245 no 1492 0.444251195745418 2111 3238678
SGTC_2269 7935389 174.42 µM 0.139544487204496 0.452993869241591 no 1493 0.444509952048731 2020 97605
SGTC_2092 5303694 80.6725 µM 0.138659370916692 0.453329180082303 no 1494 0.444859662593186 2039 1963699
SGTC_2684 capsaicin 100 µM 0.138123970329663 0.453532023407653 no 1495 0.445071220881493 2108 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_58 0957-0393 9 µM 0.137895441825563 0.453618608034246 no 1496 0.445161526445203 2067 6997992
SGTC_976 1348-1067 47.6 µM 0.137399028918065 0.453806695997434 no 1497 0.445357699289881 2124 5310671 YGL099W LSG1
SGTC_2262 9014885 67.46 µM 0.137093452142108 0.453922482415078 no 1498 0.445478464018014 2134 6457424
SGTC_40 0327-0103 19.753 µM 0.136217612835841 0.454254369273105 no 1499 0.445824625958595 2064 409036
SGTC_1857 st056007 79.3 µM 0.13334941938001 0.455341452787523 no 1500 0.446958522769878 2172 619834
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.132958700158088 0.455489566642371 no 1501 0.4471130214662 2011 4174840
SGTC_996 3970-0799 1.8 µM 0.132628774426223 0.45561463971772 no 1502 0.4472434873738 2154 6615648 YGL040C HEM2
SGTC_1525 8-methoxypsoralen 92.5 µM 0.132482088227116 0.45567024908247 no 1503 0.447301494832458 2189 4114 Related to psoralen; DNA damaging agent.
SGTC_3055 9094636 49.47 µM 0.13172177822343 0.455958499746176 no 1504 0.447602179539982 2132 25236176
SGTC_1567 st069303 68.4 µM 0.131646742474873 0.455986948749446 no 1505 0.447631856047548 2062 5581319
SGTC_1164 k060-0068 93.7 µM 0.130993876369665 0.456234485472912 no 1506 0.447890075806214 2188 5963676
SGTC_3137 9097352 49.47 µM 0.130970277798678 0.456243433281581 no 1507 0.447899409860592 2126 44120435
SGTC_912 3474-0017 2.18 µM 0.130498283673032 0.456422402718598 no 1508 0.448086105981171 2126 3360550
SGTC_1572 epiandrosterone 68.9 µM 0.1303401208254 0.456482376452426 no 1509 0.448148669482679 2089 441302 A steroid.
SGTC_2531 methyl deoxycholate 70.07 µM 0.129269162770254 0.4568884988057 no 1510 0.448572335607162 2075 16667744 Haematoxylin.
SGTC_1248 0469-0687 58.6 µM 0.128157857233511 0.457309969095322 no 1511 0.449012025018687 2106 4017482
SGTC_1289 0976-0073 69.1 µM 0.127505169411951 0.457557527866712 no 1512 0.449270290989451 2116 3391136
SGTC_2289 7946404 165.07 µM 0.126861331616276 0.457801746036349 no 1513 0.44952507609958 2095 1246120 YPR165W RHO1
SGTC_856 0433-0016 11.3 µM 0.126237260423432 0.45803848161944 no 1514 0.449772058860815 2092 3911780
SGTC_1854 st056233 32.9 µM 0.122763085887762 0.459356647101954 no 1515 0.451147353143828 2206 5393174
SGTC_1175 0741-0056 27.6 µM 0.121867492884046 0.459696524538224 no 1516 0.451501980306547 2168 765927
SGTC_833 3852-0053 558 µM 0.121503601205659 0.459834629815537 no 1517 0.45164608124445 2141 3123681
SGTC_2504 purpurogallin 52.29 µM 0.121306228663713 0.459909539271607 no 1518 0.451724243346947 2034 5281571 An antioxidant.
SGTC_1539 benzyladenosine 56 µM 0.121022921572353 0.460017066239225 no 1519 0.451836439922776 2144 92208 A nucleotide analog.
SGTC_2920 7982904 15.77 µM 0.120836161911826 0.460087950992196 no 1520 0.451910403445887 2098 6456808
SGTC_365 0121-0052 13.6 µM 0.120148986958887 0.460348779604764 no 1521 0.452182563720911 2142 3101739
SGTC_516 3992-2719 87.3 µM 0.119964029471533 0.460418986195423 no 1522 0.452255821224695 2161 5350887 YDR037W KRS1
SGTC_1617 st002906 78 µM 0.118969749227118 0.460796418480823 no 1523 0.452649661076953 2104 5150859
SGTC_1112 tnp00069 1.16933 µM 0.118677463008526 0.460907378092487 no 1524 0.452765446127711 2178 145826
SGTC_66 0109-0187 42.4 µM 0.118658907785098 0.460914422250961 no 1525 0.452772796652668 2220 759417
SGTC_2388 9080168 200 µM 0.118570193248244 0.460948101306524 no 1526 0.452807940533803 2051 15943073
SGTC_2989 9073649 71.4286 µM 0.115783347969528 0.462006223929902 no 1527 0.453912124070954 2230 21367202
SGTC_2699 st077704 54.6 µM 0.115188099150157 0.462232265936531 no 1528 0.454148015694668 2116 645852
SGTC_806 3966-4455 5.86 µM 0.114299630266796 0.462569679093564 no 1529 0.454500137791881 2038 714982
SGTC_3305 9127027 53.8275 µM 0.113322084808587 0.462940951905992 no 1530 0.454887604436694 2123 41905295
SGTC_508 roscovitine 141 µM 0.11300633046301 0.463060882658661 no 1531 0.4550127681914 2199 160355 A CDKinase inhibitor.
SGTC_1815 st051655 58.2 µM 0.112222761018108 0.463358514812182 no 1532 0.455323391240311 2220 5984156
SGTC_2933 9026794 32.47 µM 0.111630922187261 0.463583333337311 no 1533 0.455558026446995 2155 17586027
SGTC_143 4032-1194 15.74 µM 0.111550401617854 0.463613921138569 no 1534 0.455589950122105 2088 1806963
SGTC_2997 9067075 71.4286 µM 0.110131575631693 0.46415293366403 no 1535 0.45615251336518 2139 27209819
SGTC_2411 st077133 39.94 µM 0.109921860620589 0.464232610081009 no 1536 0.456235672665116 2210 1403142 YNL221C POP1
SGTC_423 5-fluorouracil 457 µM 0.109914402588642 0.464235443615924 no 1537 0.456238630069642 2018 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1325 1431-0015 227 µM 0.108902753285552 0.464619816943472 no 1538 0.456639811414859 2015 1103340
SGTC_3229 9132204 49.47 µM 0.107238753598544 0.465252120633012 no 1539 0.45729978587808 2129 17682924
SGTC_1439 4092-1168 46 µM 0.106651296730934 0.465475369565086 no 1540 0.457532810858487 2189 2886240
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.106450062649823 0.465551846266802 no 1541 0.457612637216797 2186 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1992 st073643 23.3 µM 0.106306527461211 0.465606395944528 no 1542 0.457669576387484 2223 3161292
SGTC_2611 pyromycin 23.93 µM 0.105935643580941 0.465747351103243 no 1543 0.45781670684233 2120 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2622 2-methoxyxanthone 59.94 µM 0.105338681142288 0.465974236886421 no 1544 0.458053535292872 2182 71034 A hepatoprotective.
SGTC_2034 5197015 53.07 µM 0.103262583109983 0.466763379086634 no 1545 0.458877285587204 2190 780676
SGTC_231 b-estradiol 524 µM 0.10205069958353 0.467224086736867 no 1546 0.459358216330527 2124 450 A steroid.
SGTC_509 pifithrin 175 µM 0.101955372018042 0.467260328178477 no 1547 0.45939604919575 2229 4817 A p53 inhibitor.
SGTC_1636 st007707 68.9 µM 0.100981258842619 0.467630680065283 no 1548 0.459782668698201 2203 403051
SGTC_205 1486-1330 71.903 µM 0.0999456205029468 0.468024454168578 no 1549 0.460193748861538 2184 4118834
SGTC_195 4234-0266 16.654 µM 0.0977940603445484 0.468842627629927 no 1550 0.461047911967513 2111 2303354
SGTC_3217 9129673 49.47 µM 0.0964407447859739 0.469357320376768 no 1551 0.461585266628915 2174 17248312
SGTC_1638 st008370 60.6 µM 0.0946794619988025 0.470027247716599 no 1552 0.462284715816862 2249 24207134
SGTC_717 1532-0246 73.2 µM 0.093984856378302 0.470291473640026 no 1553 0.462560593171782 2143 9561992
SGTC_2907 7721985 69.9 µM 0.0904583684819937 0.471633138565479 no 1554 0.463961487705987 2159 3267881
SGTC_1362 1611-0397 101 µM 0.090332126943439 0.471681173670256 no 1555 0.46401164544703 2210 27816
SGTC_1148 3909-7663 27.7 µM 0.0896129596772005 0.471954825787726 no 1556 0.464297392755696 2243 4084526
SGTC_1394 3474-0001 65.7 µM 0.0885874166134897 0.472345080589187 no 1557 0.46470490442601 2182 5017666 YIL048W NEO1
SGTC_391 gliotoxin 8.33 µM 0.0880971358745831 0.47253165886452 no 1558 0.464899736385639 2195 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.0868711160373587 0.472998251857018 no 1559 0.465386979382406 2189 688667
SGTC_1614 st002383 48.6 µM 0.0868581343977096 0.473003192549111 no 1560 0.465392138805448 2280 1947235
SGTC_2518 prenyletin 46.28 µM 0.0849925783153877 0.473713248765747 no 1561 0.466133645503405 2244 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_3295 9122362 53.5725 µM 0.0845736625331821 0.473872705418207 no 1562 0.466300169142082 2135 4730473
SGTC_860 0443-0016 25.1 µM 0.0841937396114665 0.47401732339763 no 1563 0.466451197791623 2266 5337942
SGTC_3221 9128209 49.47 µM 0.0814724203357994 0.475053294827289 no 1564 0.467533128665817 2197 16460723
SGTC_2603 homopterocarpin 100 µM 0.0812246757015192 0.475147616522636 no 1565 0.467631637988113 2183 101795 A weak amylase inhibitor.
SGTC_2248 tofa 1.1 µM 0.0802883252985656 0.47550411773792 no 1566 0.468003971650018 2141 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3308 9128332 17.569 µM 0.0793425558476169 0.475864225020366 no 1567 0.46838007915028 2252 17332805 YDL196W YDL196W
SGTC_890 0929-0006 47.2 µM 0.0788610042830019 0.476047586204518 no 1568 0.468571590338016 2140 1378169
SGTC_935 2996-0153 430 µM 0.0787718531894684 0.476081532971162 no 1569 0.468607046180984 2284 23738523
SGTC_1559 coumarin 343 70.1 µM 0.0786825885485957 0.476115523148058 no 1570 0.468642547431775 2238 108770 A hepatotoxic, DNA x-linker.
SGTC_3085 9117376 49.47 µM 0.0779795431393694 0.476383234731209 no 1571 0.468922162821732 2169 16480349
SGTC_1545 lovastatin 49.4 µM 0.0774158608006168 0.476597886170206 no 1572 0.46914636177701 2210 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_59 0330-0160 1.33 µM 0.0773381300652834 0.476627486734483 no 1573 0.469177279160869 2185 4293482
SGTC_2124 5246320 200 µM 0.0771297965675749 0.476706822642847 no 1574 0.469260144682501 2207 579342
SGTC_2415 st077333 57.7 µM 0.0768029418609502 0.476831294716302 no 1575 0.469390155193534 2289 2766255
SGTC_260 nsc-65238 3.989 µM 0.076752629894104 0.476850454607301 no 1576 0.469410167692182 2256 3246252
SGTC_1820 st053765 18.6 µM 0.0759030338235318 0.477174007312014 no 1577 0.469748121591416 2179 3690829
SGTC_638 3970-0837 4.09 µM 0.0756334218931922 0.477276687106743 no 1578 0.469855372891707 2195 4118451 YLR208W SEC13
SGTC_1211 1056-0033 32.3 µM 0.0736399114218047 0.478035947820294 no 1579 0.470648456307057 2272 6741922
SGTC_637 1181-0519 7.26 µM 0.0734611741113639 0.478104026751853 no 1580 0.470719569566737 2253 6252091 YGR060W ERG25
SGTC_479 n-linoleoylglycine 10 µM 0.0729219973934579 0.478309396661371 no 1581 0.470934094577174 2185 6433346 An anti-infammatory.
SGTC_1314 1222-0010 41.1 µM 0.0729102300978757 0.478313878834066 no 1582 0.470938776585792 2208 3526027
SGTC_2894 9048625 32.47 µM 0.0690796534097917 0.479773091205545 no 1583 0.472463108280106 2282 4092861
SGTC_1460 k062-0059 9.15 µM 0.0683028263612897 0.48006904787788 no 1584 0.472772287137309 2254 1373085
SGTC_1100 amiodarone 5.07 µM 0.0679867806560941 0.480189458573218 no 1585 0.472898078721707 2300 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1842 st055362 61.2 µM 0.0678825072575732 0.480229186238324 no 1586 0.472939581907491 2190 676032
SGTC_747 3448-8087 38.7 µM 0.0678450354943927 0.480243462848499 no 1587 0.47295449659384 2227 5168703
SGTC_3211 9128781 49.47 µM 0.0671204934197507 0.480519515794883 no 1588 0.473242889646937 2067 17194361
SGTC_1132 3456-3614 2.5 µM 0.0670596638016353 0.480542692509166 no 1589 0.473267102599933 2279 3125502
SGTC_1558 st069300 45.6 µM 0.066859440921524 0.48061897996357 no 1590 0.473346801104387 2292 24208000
SGTC_2783 7738165 71.43 µM 0.0664557732272672 0.480772784625318 no 1591 0.473507483841237 2202 17201110
SGTC_2930 9013230 14.89 µM 0.0661343686528516 0.480895247604705 no 1592 0.473635424254005 2265 2995857
SGTC_3002 9075603 71.4286 µM 0.0658589456318054 0.48100019192612 no 1593 0.473745063112323 2306 20105405
SGTC_2476 5806916 10.51 µM 0.0653469318999232 0.481195287803359 no 1594 0.473948887958506 2245 2870194
SGTC_1431 4049-0260 9.09 µM 0.0648426006019038 0.48138746079688 no 1595 0.47414966121244 2268 3854841
SGTC_1862 st057513 3.81 µM 0.0646354163849787 0.481466408593185 no 1596 0.474232142729264 2274 5393163
SGTC_1657 st012939 43.4 µM 0.0645568923774439 0.48149633045129 no 1597 0.474263403986456 2274 24207257
SGTC_2155 5570423 76 µM 0.0635239116128983 0.481889961163015 no 1598 0.47467465948979 2210 797402
SGTC_1650 st011916 45.8 µM 0.063026798271346 0.48207939896286 no 1599 0.474872582402033 2287 242528
SGTC_2922 7999257 32.47 µM 0.0629909666366366 0.482093053683924 no 1600 0.474886848808299 2301 2988377
SGTC_1256 0570-0116 285 µM 0.0626187584217516 0.48223489604769 no 1601 0.47503504583513 2230 410638
SGTC_222 nsc-310342 10.666 µM 0.0625837706022624 0.482248229440028 no 1602 0.475048976632034 2299 432556
SGTC_2958 9077254 16.72 µM 0.0615563389411261 0.482639778761146 no 1603 0.475458073721916 2229 16457351
SGTC_1769 st044406 64.4 µM 0.0614809165164532 0.482668522552899 no 1604 0.475488106032935 2190 670903
SGTC_974 1326-0144 138 µM 0.0613365428976333 0.482723544175358 no 1605 0.475545594276347 2236 5411856
SGTC_1689 st020265 53.493 µM 0.0606800292935954 0.482973749447378 no 1606 0.47580701834137 2294 5758320 YPR016C TIF6
SGTC_2644 guaiazulene 100 µM 0.0606536338014563 0.482983809229442 no 1607 0.475817529258859 2278 3515 A coloring agent.
SGTC_2712 st079126 47.7 µM 0.0603682523155471 0.483092573777611 no 1608 0.475931171753463 2283 3152970
SGTC_619 1652-1634 108 µM 0.0600440440704515 0.483216137500489 no 1609 0.476060277926597 2224 5400454
SGTC_2673 kobusone 100 µM 0.0599777282680459 0.483241412280094 no 1610 0.476086686508494 2302 6710676 An epoxy ketone and protein crosslinker.
SGTC_2743 auranofin 4.32 µM 0.0593482659557961 0.483481321050974 no 1611 0.476337359081138 2275 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2326 6164455 177.58 µM 0.0589997426088764 0.483614157328732 no 1612 0.476476156562335 2253 2888790
SGTC_2892 9047358 58.44 µM 0.058862785698423 0.483666357619276 no 1613 0.476530699670973 2251 6466771
SGTC_1192 1488-0095 21.4 µM 0.0587524034843456 0.483708429330275 no 1614 0.476574659723138 2206 915875
SGTC_3220 9131269 49.47 µM 0.0585571110046394 0.483782864671613 no 1615 0.47665243624466 2319 17722206
SGTC_2076 5212012 200 µM 0.0580816718675433 0.483964079713505 no 1616 0.476841786737624 2313 604802
SGTC_428 3448-4153 16.5 µM 0.0575503629644206 0.484166593600339 no 1617 0.4770533943553 2272 3834874
SGTC_2336 9001819 198.65 µM 0.0570875735283242 0.484342993913312 no 1618 0.477237717584122 2269 2989602
SGTC_1588 farnesol 29.9 µM 0.0568067782020617 0.484450025474235 no 1619 0.47734955721754 2310 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_998 3996-0085 177 µM 0.0541327969260066 0.485469329637139 no 1620 0.478414681189043 2269 715391
SGTC_2676 harmalol 100 µM 0.0530961820689903 0.485864506341525 no 1621 0.478827636715695 2306 5459187 A monoamine oxidase inhibitor
SGTC_1835 st008666 49.2 µM 0.0528449708913092 0.485960274780617 no 1622 0.478927714973094 2221 690455
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.051861605212021 0.48633516789131 no 1623 0.4793194838427 2299 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1774 st048371 48.465 µM 0.0518593167585531 0.486336040343374 no 1624 0.479320395576662 2288 4242727
SGTC_1670 st016595 4.04 µM 0.0516203697439125 0.48642713707784 no 1625 0.479415594134224 2316 597879
SGTC_1225 1216-0074 20.6 µM 0.050189924072749 0.486972498271516 no 1626 0.479985520430463 2259 4241466
SGTC_2753 fluvastatin 17.09 µM 0.0479605884665926 0.487822486559643 no 1627 0.480873826143718 2270 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2849 9019321 12.99 µM 0.0477253116774805 0.48791219483799 no 1628 0.480967580641273 2274 16489627
SGTC_3092 9117248 49.47 µM 0.0473431223966877 0.488057920426816 no 1629 0.481119879946066 2334 17141857
SGTC_1969 st069479 40.1 µM 0.0473168277720107 0.488067946406992 no 1630 0.481130358240669 2328 3895485
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.0469236580251079 0.48821786053173 no 1631 0.481287036241054 2305 6728940
SGTC_2168 5727979 200 µM 0.0465324556993431 0.488367026138593 no 1632 0.481442933093787 2315 695210
SGTC_1840 st055363 71 µM 0.0460137100746696 0.488564826563573 no 1633 0.481649661212473 2195 676033
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.0458301840075422 0.48863480669075 no 1634 0.481722800360592 2315 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2947 9072639 7.68 µM 0.0451447661771671 0.488896165702373 no 1635 0.481995959762817 2307 16488146
SGTC_405 ebelactone b 50 µM 0.0443524735339796 0.489198283447749 no 1636 0.482311722482276 2215 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1846 st056244 14.8 µM 0.044212629919591 0.489251609389397 no 1637 0.482367457339379 2264 5393182
SGTC_3261 9137475 49.47 µM 0.0440895794475559 0.489298531835929 no 1638 0.48241649955248 2332 17027690
SGTC_1776 st049249 45.9 µM 0.0440645358842527 0.489308081636717 no 1639 0.482426480788315 2294 1822314
SGTC_2257 7960413 200 µM 0.0428584897639698 0.489767987409797 no 1640 0.482907169347199 2269 2974689 YIL048W NEO1
SGTC_1165 k072-0275 30.3 µM 0.0420540282345511 0.490074763131769 no 1641 0.483227813938958 2324 6153523 YGL055W OLE1
SGTC_337 1315-0038 354 µM 0.0420271446665129 0.490085015092945 no 1642 0.483238529457349 2298 1626437
SGTC_1884 5633444 25 µM 0.0412477021367275 0.490382255785537 no 1643 0.483549212601203 2302 5724239
SGTC_730 1436-0052 41.2 µM 0.0408599373479385 0.490530132028845 no 1644 0.483703778060878 2338 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_370 0180-0345 38.7 µM 0.0405458148150559 0.490649925346485 no 1645 0.483828991055292 2280 3989527
SGTC_2787 5284540 71.43 µM 0.0404164037980453 0.490699277591838 no 1646 0.483880576297281 2277 736958
SGTC_386 1509-0011 3.07 µM 0.0375480536425405 0.4917931881202 no 1647 0.485024012936233 2336 3107280
SGTC_2840 9008771 71.43 µM 0.0362748498630796 0.492278773589862 no 1648 0.485531601819785 2336 2992978
SGTC_3140 9094243 49.47 µM 0.0361757744723823 0.49231656030841 no 1649 0.485571101256534 2355 19291112
SGTC_2931 9014674 55.67 µM 0.0352573437988441 0.492666847114091 no 1650 0.485937268441743 2335 2996810
SGTC_1870 st057514 26.5 µM 0.0349834060482272 0.492771327287913 no 1651 0.486046486414598 2339 5393161
SGTC_545 4218-0007 221 µM 0.0346877966261617 0.492884073618303 no 1652 0.486164345977 2311 2840508
SGTC_460 trequinsin 123 µM 0.0337607064975611 0.493237672251454 no 1653 0.486533984871502 2348 5537 A vasodilator.
SGTC_3132 9126706 49.47 µM 0.0326342915634759 0.493667301877143 no 1654 0.486983111836491 2298 850858
SGTC_1872 amphotericin b 148 nM 0.0324034040244525 0.493755366376452 no 1655 0.487075173948038 2334 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2821 7996764 71.43 µM 0.0320656172701035 0.493884204631846 no 1656 0.487209861372882 2322 2987135
SGTC_2708 st078559 56 µM 0.0320521224080858 0.493889351840739 no 1657 0.487215242278029 2343 17250902
SGTC_2981 9013952 38.96 µM 0.0304457445036003 0.494502063364617 no 1658 0.487855781455313 2270 2996344
SGTC_1146 3579-1023 7 µM 0.0296447520108501 0.494807586280048 no 1659 0.488175187019473 2344 X1146
SGTC_2571 chrysanthemic acid 100 µM 0.0290142564905043 0.495048078612231 no 1660 0.48842661017313 2287 2743 An insecticide.
SGTC_1421 4029-0249 71.4 µM 0.0285550831295386 0.495223224011586 no 1661 0.488609717965889 2352 2894095
SGTC_3314 9135860 59.4275 µM 0.0278839491861659 0.49547922052365 no 1662 0.488877355080258 2340 25252478
SGTC_1940 st075990 51.1 µM 0.027697506253581 0.495550337423181 no 1663 0.488951706331647 2297 1084979
SGTC_3037 9091026 49.47 µM 0.0269512377202645 0.495834995915297 no 1664 0.489249313274635 2356 25236398 YIL048W NEO1
SGTC_2909 7941780 10.49 µM 0.0259060274698397 0.496233686998736 no 1665 0.48966614621785 2362 1243215
SGTC_1356 1502-0781 85.8 µM 0.0253850867477579 0.496432399090397 no 1666 0.489873903163577 2357 567702
SGTC_1017 4239-0030 168 µM 0.0250408040391357 0.496563725724934 no 1667 0.490011208442867 2328 1149593
SGTC_2065 5221596 34.26 µM 0.0249115531095404 0.496613028587185 no 1668 0.490062756022985 2338 788581
SGTC_1477 0139-0234 16 µM 0.0223944196420167 0.497573200390794 no 1669 0.491066665858768 2365 620880
SGTC_1731 st035964 63 µM 0.0217470966439145 0.497820127134743 no 1670 0.491324847477118 2211 6739575
SGTC_31 0508-1974 57.237 µM 0.0199394020436953 0.498509691404818 no 1671 0.492045856550072 2372 6810525
SGTC_734 2023-0417 80 µM 0.0197972864395529 0.498563903124312 no 1672 0.492102541283937 2356 3935732
SGTC_1866 st057638 64 µM 0.0197011400504494 0.498600579344731 no 1673 0.492140890664182 2356 688802
SGTC_788 1182-0090 188 µM 0.0182578781771264 0.499151130551207 no 1674 0.492716565102618 2359 5715185
SGTC_937 3122-0005 46.7 µM 0.0179009928869843 0.499287269424589 no 1675 0.492858918466216 2364 759535
SGTC_3065 9113888 49.47 µM 0.0172292818782845 0.49954350317341 no 1676 0.49312685104641 2366 16648368
SGTC_3174 9107204 49.47 µM 0.0172140212719598 0.499549324552032 no 1677 0.493132938244744 2369 3938802
SGTC_3296 9122258 64.045 µM 0.0161788980654276 0.499944187404277 no 1678 0.493545835082822 2365 4730474
SGTC_1453 4237-0541 195 µM 0.0158862754552666 0.499944187404277 no 1679 0.493662559611176 2371 739892
SGTC_308 4092-1169 104 µM 0.0158572893465887 0.499933130227592 no 1680 0.493674121939026 2374 2268590 YDL196W YDL196W
SGTC_1327 1436-0082 2.18 µM 0.0152234870172274 0.499691357052144 no 1681 0.493926941951071 2318 15992205
SGTC_2749 bexarotene 57.39 µM 0.0149330538693188 0.499580567109344 no 1682 0.494042794842423 2359 82146 An retinoic acid receptor inhibitor.
SGTC_327 1273-0057 3.96 µM 0.0147608801851272 0.499514888971418 no 1683 0.494111474634491 2375 3108138
SGTC_1766 st045414 44.774 µM 0.0140850777872756 0.499257094532415 no 1684 0.494381052738472 2385 253960
SGTC_3018 9082602 49.47 µM 0.0139035850915712 0.499187861609993 no 1685 0.494453450758664 2360 17332089
SGTC_868 0527-0199 213 µM 0.0137925625152274 0.499145510510291 no 1686 0.494497738111746 2314 2849450
SGTC_115 0527-0192 112.043 µM 0.0111669948005401 0.498143955191419 no 1687 0.495545106218093 2349 4233931
SGTC_1983 st071813 46.9 µM 0.0106489871065997 0.497946355923919 no 1688 0.495751749092477 2337 11838595
SGTC_311 1315-0136 58 µM 0.0105793705528861 0.497919800023614 no 1689 0.495779520514745 2379 6759207
SGTC_1199 1638-0010 4.46 µM 0.0102373005560523 0.497789314287527 no 1690 0.495915979306947 2375 3111136
SGTC_2408 sulbentine 18.36 µM 0.0102111745878388 0.497779348306997 no 1691 0.495926401515527 2320 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1068 loratadine 26.9 µM 0.010009155388171 0.497702286352416 no 1692 0.49600699139672 2366 3957 A H1 histamine antagonist.
SGTC_2772 vinpocetine 57.06 µM 0.00999756789515757 0.497697866206499 no 1693 0.49601161390632 2386 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2048 5246248 200 µM 0.00941478971675508 0.497475560982615 no 1694 0.496244097807089 2398 677046
SGTC_1954 st077032 68.9 µM 0.00801090100451308 0.496940040174342 no 1695 0.496804147067289 2343 698907
SGTC_2115 tiliquinol 12.7705 µM 0.00769049956524092 0.496817822081024 no 1696 0.496931964808581 2383 71208 A bioactive hydroxyquinoline.
SGTC_2152 5568786 200 µM 0.00748706823940793 0.496740222743814 no 1697 0.497013119828596 2392 5399883
SGTC_2165 5727197 32.143 µM 0.00743267951467558 0.496719476063098 no 1698 0.497034817186732 2372 1361712
SGTC_2463 5473429 200 µM 0.00577631818341342 0.496087658450407 no 1699 0.49769559526633 2358 5399405
SGTC_1506 4226-2149 212 µM 0.0054571404480587 0.495965909455043 no 1700 0.497822926750865 2362 991114
SGTC_1342 1486-1464 234 µM 0.00542014718054489 0.495951798553906 no 1701 0.497837684711102 2398 3253938
SGTC_560 2332-1943 155 µM 0.00351778877589883 0.495226160463114 no 1702 0.498596608218231 2397 21177716
SGTC_2970 9090938 41.86 µM 0.00278592800793868 0.49494700260563 no 1703 0.498888576965178 2399 17217104
SGTC_1169 aniline yellow 25.8 µM 0.00129014156997798 0.494376464035409 no 1704 0.499485308122813 2400 6051 A DNA damaging agent.
SGTC_792 4534-1957 155 µM 0.000959643597179065 0.494250403538823 no 1705 0.49961715765373 2401 1717904
SGTC_1932 st074806 40.9 µM 0.00081429447816876 0.494194963796989 no 1706 0.499675143539862 2397 17251235
SGTC_2163 5671233 125 µM 0.000628837267287167 0.494124226001815 no 1707 0.499749130243121 2402 701023
SGTC_2812 7970281 58.44 µM 0.000520745824212847 0.494082997437314 no 1708 0.499792252482768 2405 2233435
SGTC_1685 st024049 53.0905 µM -0.00139893589266479 0.493350797580649 no 1709 0.499441905506879 2412 1941139
SGTC_585 0kpi-0023 191 µM -0.00193619449715194 0.493145881749322 no 1710 0.499227570634626 2405 64601
SGTC_2242 6630449 61.2675 µM -0.00245077611254788 0.492949616844619 no 1711 0.499022282767651 2432 691249 YDR170C SEC7
SGTC_2596 sinensetin 100 µM -0.00309307142452367 0.492704643473382 no 1712 0.498766045000016 2416 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2432 5630864 12.22 µM -0.0040984083504869 0.492321210493077 no 1713 0.498364976203878 2421 5714970
SGTC_3082 9117008 49.47 µM -0.00426340835487281 0.49225828057389 no 1714 0.498299151301248 2420 41448529
SGTC_832 4083-0019 164 µM -0.00551964800114245 0.491779165445596 no 1715 0.497797990220677 2423 1990758
SGTC_2434 5670830 169.91 µM -0.00570304772677164 0.491709219908005 no 1716 0.497724825467899 2422 1549830
SGTC_2792 7535235 81.82 µM -0.00650647834462943 0.491402808161662 no 1717 0.497404309006267 2436 1281891
SGTC_1131 3454-3128 32.3 µM -0.00690534058746535 0.49125069226179 no 1718 0.497245189572378 2433 710982
SGTC_1821 st053465 65.6 µM -0.00691017742939271 0.491248847621244 no 1719 0.497243259997667 2420 675086
SGTC_1398 3558-0053 112 µM -0.00803181326421443 0.490821091219691 no 1720 0.496795804551107 2422 4532369
SGTC_318 1488-0629 67.2 µM -0.00808054718072946 0.490802505882361 no 1721 0.496776363162225 2435 3662576
SGTC_2258 7960471 200 µM -0.00816864541063524 0.490768908483117 no 1722 0.49674121821346 2431 2974708
SGTC_1673 st016611 27.3 µM -0.00829075594934428 0.490722340158422 no 1723 0.496692504806375 2432 5226799
SGTC_2545 solidagenone 89.61 µM -0.00849353370464782 0.490645008698759 no 1724 0.496611611035045 2419 6708572 An anti ulcer agent
SGTC_2667 digitoxin 100 µM -0.00860569556810616 0.490602234726748 no 1725 0.496566866560835 2425 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_329 k048-0121 21.3 µM -0.00996044528221572 0.49008559697626 no 1726 0.496026422948816 2440 6832902
SGTC_3239 9133757 49.47 µM -0.0101132862431781 0.490027311658557 no 1727 0.495965451298549 2423 17036923
SGTC_1946 st076057 65.1 µM -0.0107699908659291 0.489776882293358 no 1728 0.495703478345064 2438 953009
SGTC_2576 guaiol 23.12 µM -0.0107753357819143 0.489774844066276 no 1729 0.495701346155817 2438 227829
SGTC_1253 0550-0034 176 µM -0.0111195732736003 0.489643573310734 no 1730 0.495564023495647 2436 5969915
SGTC_3256 9138902 49.47 µM -0.0112016027748186 0.489612292529092 no 1731 0.49553130049741 2425 17228773
SGTC_2094 5332512 191.667 µM -0.0113731538470426 0.489546874178492 no 1732 0.495462865881128 2426 755774
SGTC_623 k072-0108 16.9 µM -0.0116307768292489 0.489448634163778 no 1733 0.495360095979614 2454 5382803
SGTC_2768 sulfasalazine 50.2 µM -0.012100476389799 0.489269524109858 no 1734 0.4951727261582 2431 5384001 An antioxidant and salicylic acid derivative.
SGTC_1143 3454-2408 5.08 µM -0.0122787546421405 0.489201542010478 no 1735 0.49510160870951 2410 X1143
SGTC_2356 9061756 188.97 µM -0.0124309990624871 0.4891434875315 no 1736 0.495040876608678 2416 20104043
SGTC_2108 5365811 200 µM -0.01493451711306 0.488188869457586 no 1737 0.494042211157718 2452 780283
SGTC_1232 0279-0259 161 µM -0.0159921458939583 0.487785604362908 no 1738 0.493620328781847 2442 1560000
SGTC_2439 5492030 7.2 µM -0.0172116083413326 0.487320648958046 no 1739 0.493133900722198 2444 5722370
SGTC_537 1334-0398 209 µM -0.0179933621355415 0.487022591689801 no 1740 0.492822074401807 2435 5846986
SGTC_2171 5739187 198.077 µM -0.0191093682555239 0.48659710749423 no 1741 0.492376929004142 2438 2262761
SGTC_2954 9074818 52.69 µM -0.0224875621009406 0.485309245299792 no 1742 0.491029516749104 2473 16648742
SGTC_2058 5236698 133 µM -0.0226993618142499 0.485228506276212 no 1743 0.490945042451964 2458 766665
SGTC_3341 9147222 25.867 µM -0.0228386669527886 0.485175402847453 no 1744 0.490889482146245 2481 1939759
SGTC_2032 5185112 25.99 µM -0.0237755999091708 0.484818248797091 no 1745 0.490515801499353 2447 5718189
SGTC_3287 9117173 37.0625 µM -0.023942305561918 0.484754702723065 no 1746 0.490449314492713 2444 2789709
SGTC_1445 4239-0156 97.7 µM -0.0242052662798953 0.484654466230399 no 1747 0.490344438739155 2465 4008346
SGTC_171 k064-0041 9.68 µM -0.0248619614469764 0.48440414860259 no 1748 0.490082534108202 2446 53325
SGTC_2871 9038510 12.99 µM -0.0254395674575552 0.484183983083658 no 1749 0.489852175521816 2457 4945164
SGTC_2214 7179297 48.276 µM -0.0266483524452413 0.483723247374134 no 1750 0.489370103631132 2446 769744
SGTC_2017 5132927 60.65 µM -0.0266598692621641 0.483718857773244 no 1751 0.489365510717715 2472 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2524 avocatin b 10.57 µM -0.0272135869607339 0.483507812239391 no 1752 0.48914468944626 2451 6710748
SGTC_1471 k673-0312 37 µM -0.0281464635806454 0.483152263479285 no 1753 0.488772668079338 2465 24099884
SGTC_255 tunicamycin 200.472 nM -0.0287119160810799 0.482936758165664 no 1754 0.488547176314119 2461 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2679 rapamycin 1 nM -0.0290613707546117 0.482803576453901 no 1755 0.488407822223789 2467 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_767 0929-0023 86 µM -0.0296290874608158 0.482587216345997 no 1756 0.488181433526882 2461 1204563
SGTC_3339 9145883 14.936 µM -0.0297984459296704 0.482522673847841 no 1757 0.488113899093117 2478 2030670
SGTC_649 1123-0311 367 µM -0.0302070661022693 0.482366950623664 no 1758 0.487950956584884 2480 693629 YIL048W NEO1
SGTC_924 2046-0044 21.3 µM -0.0309808145567399 0.482072086119283 no 1759 0.487642420046917 2459 3623589
SGTC_3212 9128307 49.47 µM -0.0316874758185134 0.481802796151672 no 1760 0.487360641360688 2501 27243542
SGTC_2756 carbadox 75.1 µM -0.0329730493770517 0.481312919354511 no 1761 0.486848039716297 2486 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_52 0329-0193 875 nM -0.0335745323961394 0.481083729686937 no 1762 0.48660821550951 2569 3739292
SGTC_3050 9093513 49.47 µM -0.0341579883928318 0.480861415026675 no 1763 0.486375583690693 2470 25236664
SGTC_1111 tnp00062 510.699 nM -0.036472362439252 0.479979626715776 no 1764 0.485452857810307 2514 676306
SGTC_866 0495-0101 262 µM -0.0367078700735744 0.479889902525626 no 1765 0.485358966731284 2490 635694
SGTC_1760 st045453 10.4495 µM -0.0370346241930004 0.479765416747651 no 1766 0.485228699277008 2449 3323419 YIL048W NEO1
SGTC_965 1291-5240 308 µM -0.0373009176629393 0.479663966540726 no 1767 0.48512253690714 2483 2834598
SGTC_823 0417-1665 178 µM -0.0423522318278331 0.477739817045123 no 1768 0.483108953816148 2532 3429856
SGTC_3294 9122953 26.2835 µM -0.0426848892439038 0.477613118708792 no 1769 0.482976362613827 2473 16459826
SGTC_2151 5563267 85.4165 µM -0.0435499149548166 0.477283669313916 no 1770 0.482631587930943 2504 5310824
SGTC_3005 9076496 71.4286 µM -0.044917380928447 0.4767628947743 no 1771 0.482086581424487 2489 21368410
SGTC_2895 9054447 58.44 µM -0.0455727409874278 0.476513326829848 no 1772 0.481825398065863 2482 2697450
SGTC_1758 st042942 75.2445 µM -0.0456109333975458 0.476498783044941 no 1773 0.481810177325935 2477 669317
SGTC_878 0828-0289 13.7 µM -0.0460028407310061 0.476349545363204 no 1774 0.481653992866255 2498 745350 YLR208W SEC13
SGTC_320 4092-0846 5.34 µM -0.0466924589362071 0.476086947927981 no 1775 0.481379170344646 2567 1359356
SGTC_2738 aclarubicin 5.55 µM -0.048358830659172 0.475452458839846 no 1776 0.480715134634237 2539 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1822 st052468 42 µM -0.0485209860188015 0.475390719727137 no 1777 0.480650519856699 2504 2873678
SGTC_3289 9119912 71.43 µM -0.0490186135627641 0.475201256462605 no 1778 0.480452231146032 2531 17014829
SGTC_2355 9061122 103.12 µM -0.0491898793947002 0.475136051190823 no 1779 0.480383988288695 2524 5302957
SGTC_1662 st014054 52 µM -0.0493471448892026 0.475076176791166 no 1780 0.480321324534495 2485 2838777
SGTC_1406 3909-7906 11.9 µM -0.0495702768070843 0.474991226575449 no 1781 0.48023241658677 2503 X1406
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.0496039621479671 0.474978402076906 no 1782 0.480218994591765 2498 803109
SGTC_419 nsc-638432 893 µM -0.0499916574463081 0.47483080271526 no 1783 0.480064518202067 2538 368090
SGTC_145 3737-0113 38.366 µM -0.050087474032519 0.47479432494281 no 1784 0.480026340741993 2547 6849351
SGTC_3196 9111891 49.47 µM -0.0503717059354396 0.474686117920731 no 1785 0.479913091573499 2475 18891510
SGTC_1064 honokiol 6.76 µM -0.0507130857030634 0.474556157188181 no 1786 0.479777074592163 2540 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2614 arthonioic acid 13.39 µM -0.0521308650260962 0.47401644829565 no 1787 0.479212209830299 2489 6710684
SGTC_1344 1488-0097 29.1 µM -0.0528814696684531 0.473730733367284 no 1788 0.478913174398873 2558 747966
SGTC_185 k048-0037 25.491 µM -0.054566340001183 0.473089443028803 no 1789 0.478241977787967 2497 6827589
SGTC_1418 3966-3099 2.4 µM -0.054781006398762 0.473007742316743 no 1790 0.478156466187601 2504 740335
SGTC_820 1582-0060 59.9 µM -0.0549038762674647 0.472960979310352 no 1791 0.478107521862153 2529 3848840
SGTC_1181 1222-0449 220 µM -0.0550601643738684 0.472901498205473 no 1792 0.478045266100088 2550 658318
SGTC_3007 9078383 71.4286 µM -0.0563008368270369 0.472429336870813 no 1793 0.477551076101221 2534 6496995
SGTC_1476 4112-3294 3.34 µM -0.057015298199795 0.472157452636893 no 1794 0.477266504381764 2604 704369
SGTC_3071 9117417 49.47 µM -0.0589984998286209 0.471402824852434 no 1795 0.476476651497765 2545 45595590 YGL055W OLE1
SGTC_840 0245-0196 390 µM -0.0595802159410798 0.471181495484731 no 1796 0.476244987881823 2617 3827528
SGTC_1886 st057356 49.9 µM -0.0604632759314559 0.470845528857073 no 1797 0.475893331937396 2527 24207747
SGTC_1237 0330-0133 46.1 µM -0.0605933339454599 0.470796049082342 no 1798 0.47584154125582 2527 X1237 YHR072W ERG7
SGTC_2809 7964133 12.99 µM -0.0610887276688484 0.470607583710652 no 1799 0.475644273200986 2541 1253665
SGTC_1044 1222-0021 1.78 µM -0.0613612365792468 0.470503914444004 no 1800 0.475535761443963 2652 4306703
SGTC_3 0833-0587 95.581 µM -0.0613613732181719 0.470503862463609 no 1801 0.475535707035445 2459 5382644
SGTC_457 grayanotoxin iii 135 µM -0.0630064199298781 0.469878087892862 no 1802 0.474880696058003 2569 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_332 4112-0506 40.9 µM -0.0652455196821104 0.469026455807601 no 1803 0.47398925942429 2525 2790355
SGTC_2215 7188065 200 µM -0.065693022057348 0.468856267044066 no 1804 0.473811114002826 2541 940217
SGTC_1250 0485-0349 40.2 µM -0.0662092970407428 0.468659930574524 no 1805 0.473605597524936 2553 6842794 YDL195W SEC31
SGTC_75 0159-0059 199.013 µM -0.0662570576524509 0.468641767867216 no 1806 0.473586585544556 2530 5377270
SGTC_101 0490-5701 117.494 µM -0.0707525829794264 0.466932478499955 no 1807 0.471797335247339 2537 4661669
SGTC_3354 9151612 71.43 µM -0.0712376640258782 0.466748076786834 no 1808 0.471604302994843 2578 27261949
SGTC_3355 9151058 44.0485 µM -0.071388286245872 0.466690819773622 no 1809 0.471544366022854 2528 17015728
SGTC_1498 4478-3555 97.6 µM -0.0723716584565028 0.4663170210345 no 1810 0.471153069455166 2517 3437919
SGTC_1676 st018489 23.4 µM -0.0727637637563447 0.466167982515889 no 1811 0.470997053410897 2597 3696235
SGTC_226 1,3-diallylurea 8.28947 mM -0.0728867870469228 0.466121222561413 no 1812 0.470948104192693 2627 74537 YKL182W FAS1
SGTC_1914 st062367 72.6 µM -0.0730783366035565 0.46604841737189 no 1813 0.470871890221518 2565 978205
SGTC_990 3985-0011 41.3 µM -0.074827878362806 0.46538349498177 no 1814 0.470175830133705 2599 5399565 YGL099W LSG1
SGTC_500 h-89 112 µM -0.0751896193551974 0.465246025442328 no 1815 0.470031921764757 2620 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1135 dihydrocapsaicin 536.708 nM -0.0757749464678637 0.465023597047905 no 1816 0.469799074313621 2522 107982 A Capsaicinoid.
SGTC_598 3937-0236 20.2 µM -0.0761057449597769 0.464897896137383 no 1817 0.469667484791256 2597 1379313
SGTC_3331 9141060 1.957 µM -0.0762122131845014 0.464857439766432 no 1818 0.469625133117067 2551 4906567 YPR165W RHO1
SGTC_2883 9059145 45.46 µM -0.0764090646255041 0.464782640049971 no 1819 0.469546829081141 2524 16476510
SGTC_107 0358-0022 2.6945 µM -0.0782988855980684 0.464064608566187 no 1820 0.468795151953509 2627 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_118 0083-0097 135.343 µM -0.079819224256278 0.463487045546742 no 1821 0.468190517180671 2570 5207356
SGTC_2978 9011784 42.97 µM -0.0805411656458233 0.463212813359343 no 1822 0.467903428554216 2704 2994934
SGTC_1352 1496-0991 99 µM -0.0808951619862446 0.463078352879811 no 1823 0.4677626637664 2557 3000039
SGTC_1941 st076221 61.8 µM -0.0812776638022669 0.46293306974224 no 1824 0.467610568457195 2685 2828568
SGTC_1195 1502-0147 41.1 µM -0.0819403261205576 0.462681386805479 no 1825 0.467347083317332 2543 817940
SGTC_1124 fisetin 1.16336 µM -0.0820457341485367 0.462641353608444 no 1826 0.467305172714834 2634 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_675 1309-0189 238 µM -0.0835307045837402 0.462077413115305 no 1827 0.466714781984213 2597 4246530
SGTC_1491 4138-0063 26.5 µM -0.0842441117311426 0.461806512753438 no 1828 0.46643117336431 2544 23883227
SGTC_229 benomyl 22.8748 µM -0.0860348469824957 0.461126599542565 no 1829 0.465719358014145 2634 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_268 camptothecin 39.6153 µM -0.0869549060719094 0.460777312045126 no 1830 0.465353678009927 2550 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_600 1495-0418 41.6 µM -0.0872750800367012 0.460655769584431 no 1831 0.46522643083686 2566 5377768
SGTC_1391 3442-0225 151 µM -0.0895455068076827 0.459793990317018 no 1832 0.464324194805551 2578 5227075
SGTC_2488 5268135 45.7 µM -0.0896972251571125 0.459736409712559 no 1833 0.464263910529427 2648 1270356 YLR208W SEC13
SGTC_2167 5876490 200 µM -0.0897793464424493 0.45970524314745 no 1834 0.464231280525515 2811 686534
SGTC_273 hydroxyurea 18.1 mM -0.0902490042839772 0.459527003967687 no 1835 0.464044671694233 2573 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_902 1120-0002 2.07 µM -0.0911856021620383 0.459171581359094 no 1836 0.463672557549769 2590 3280475
SGTC_2069 5228469 200 µM -0.0914543625320708 0.459069597484979 no 1837 0.463565783815861 2657 2835210
SGTC_535 2293-4129 48.2 µM -0.0919252434203283 0.458890923408759 no 1838 0.4633787175123 2556 396118 YIL048W NEO1
SGTC_2587 piperic acid 92.2 µM -0.09208848902676 0.458828982381423 no 1839 0.463313867007903 2620 5370536
SGTC_2491 paeonol 100 µM -0.0938135577524999 0.458174493045002 no 1840 0.462628630827888 2567 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2737 bleomycin 30.5 nM -0.0938509605306169 0.458160303718131 no 1841 0.462613774822256 2581 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_3205 9113483 49.47 µM -0.0946937569083633 0.457840589946655 no 1842 0.462279038480406 2698 17018033
SGTC_3276 9139060 49.47 µM -0.0958119645666376 0.457416441383158 no 1843 0.461834957364712 2560 4870619
SGTC_755 1995-0008 37.3 µM -0.0967090151946115 0.457076215168976 no 1844 0.461478740151404 2568 689533
SGTC_1154 4088-0362 150 µM -0.0971465919028072 0.45691026596183 no 1845 0.461304990412316 2573 6618304
SGTC_2810 7959871 45.46 µM -0.0988127291283548 0.456278459139749 no 1846 0.460643480787847 2660 2974535
SGTC_2298 7976326 193.81 µM -0.0999652628702106 0.455841477672326 no 1847 0.46018595173908 2629 2235818
SGTC_2086 5274770 176.623 µM -0.100572754046484 0.455611169751693 no 1848 0.459944813068406 2631 689278
SGTC_1397 3532-0190 20.1 µM -0.100998014282688 0.455449956855657 no 1849 0.459776018245024 2568 5322280
SGTC_2564 betulinic acid 100 µM -0.101503207461727 0.455258451529144 no 1850 0.459575505762448 2659 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_958 1222-0007 33 µM -0.101554370776012 0.455239057453584 no 1851 0.45955519948288 2702 7312461
SGTC_3272 9137413 49.47 µM -0.10293919534326 0.454714163556855 no 1852 0.459005614767678 2590 17614870
SGTC_2316 5844804 197.44 µM -0.103943461295333 0.454333563252531 no 1853 0.458607108379486 2675 776813
SGTC_1367 1812-0510 76.9 µM -0.104809434298906 0.454005407354812 no 1854 0.45826351189837 2637 1142582 YDR527W RBA50
SGTC_896 0964-0007 44.5 µM -0.106151235984827 0.453497000782245 no 1855 0.457731180154526 2565 6756758
SGTC_2174 5790901 200 µM -0.106613895832752 0.453321717310784 no 1856 0.45754764707022 2653 786020
SGTC_449 xestospongin c 11.1929 µM -0.107188203116374 0.453104147706664 no 1857 0.457319837029621 2687 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_696 1560-0013 611 µM -0.107890022736362 0.452838290662089 no 1858 0.457041465812726 2729 1650269
SGTC_2991 9074669 71.4286 µM -0.108026185648804 0.452786713087749 no 1859 0.456987460304564 2699 17333109
SGTC_1553 gossypol 38.6 µM -0.108479108128412 0.452615154905444 no 1860 0.456807826003284 2573 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3001 9076041 71.4286 µM -0.1094631780818 0.452242438972545 no 1861 0.456417562930517 2622 16004211
SGTC_475 α-linolenic acid 10 µM -0.110463603711453 0.451863571475453 no 1862 0.456020856606081 2809 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1675 st018485 24.5 µM -0.112588110040601 0.451059153332951 no 1863 0.455178555960839 2679 3323024
SGTC_3253 9135987 49.47 µM -0.112808374764687 0.450975764250481 no 1864 0.455091239313822 2707 4182430
SGTC_2942 9052777 62.25 µM -0.114401841809449 0.450372565028239 no 1865 0.454459627015016 2634 6469503
SGTC_359 0081-0058 15.9 µM -0.115169384273469 0.450082056366092 no 1866 0.454155432490594 2885 3494159
SGTC_2441 5730946 39.09 µM -0.116133409356802 0.449717218521549 no 1867 0.453773405554244 2726 1774275
SGTC_1350 1495-0454 146 µM -0.116437626455145 0.449602095562639 no 1868 0.453652858292706 2732 1069057
SGTC_1891 st059073 26.2 µM -0.116778215862454 0.449473213493348 no 1869 0.453517903422734 2674 688754
SGTC_2703 st077852 53.4 µM -0.116927946673801 0.449416555704847 no 1870 0.453458575905336 2737 6281836
SGTC_2216 7189485 200 µM -0.118722165389018 0.448737708089166 no 1871 0.452747737651643 2658 731273
SGTC_2517 totarol 10 µM -0.11906400501859 0.448608389076449 no 1872 0.452612323836568 2672 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_3171 9103192 49.47 µM -0.119815553426113 0.448324095155073 no 1873 0.45231463042555 2622 13018434
SGTC_1494 4358-1428 177 µM -0.120271926776768 0.448151472283771 no 1874 0.452133870922659 2670 1564571
SGTC_108 0509-0257 621.132 µM -0.120371369154651 0.448113859581851 no 1875 0.452094485286846 2711 536624
SGTC_1907 st060210 83.7 µM -0.12121853645628 0.447793449233386 no 1876 0.451758971206174 2738 688793
SGTC_936 3005-4620 401 µM -0.121855429022431 0.447552590105276 no 1877 0.451506757487909 2685 777207
SGTC_2179 6298986 200 µM -0.122573700114597 0.447280978569035 no 1878 0.451222340818374 2710 738374
SGTC_2808 7946468 45.46 µM -0.122751398480191 0.447213786404242 no 1879 0.451151980745714 2689 2970879
SGTC_2775 cyproheptadine 69.59 µM -0.124106208767357 0.446701548938352 no 1880 0.450615591141404 2628 2913 A selective serotonin reuptake inhibitor.
SGTC_2823 7987624 58.44 µM -0.124598194365018 0.446515557066157 no 1881 0.450420828973021 2751 2239440
SGTC_762 1165-0429 115 µM -0.125875851445041 0.446032602383145 no 1882 0.449915099181737 2709 5967793
SGTC_1035 k081-0041 55.2 µM -0.125907145352857 0.446020774279989 no 1883 0.449902713258906 2607 731709
SGTC_3241 9133421 49.47 µM -0.126097154477997 0.445948957897669 no 1884 0.449827509945406 2612 17018221
SGTC_1783 st039459 87.517 µM -0.126102698509084 0.44594686248673 no 1885 0.449825315711999 2857 729761
SGTC_2793 7325131 81.82 µM -0.128883686729419 0.444895957249812 no 1886 0.448724842552649 2717 4176441
SGTC_1761 st044296 37 µM -0.128999473347932 0.444852211089294 no 1887 0.448679032777374 2618 1826700
SGTC_3310 9130229 44.1445 µM -0.129232566516742 0.444764146549702 no 1888 0.448586813957389 2772 7761258
SGTC_2458 5808907 16.39 µM -0.129790019020778 0.444553547417707 no 1889 0.448366279892612 2635 2731747
SGTC_2348 9022543 33.42 µM -0.129963772539788 0.444487908537346 no 1890 0.448297544434276 2739 3162678 YDL140C RPO21
SGTC_1695 st026914 34.495 µM -0.130232222672914 0.444386499103372 no 1891 0.448191350829095 2621 3289191
SGTC_2419 paclitaxel 166.5 µM -0.130972989767171 0.444106686624384 no 1892 0.447898337181401 2587 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_527 4476-4215 268 µM -0.13126122711201 0.443997817271019 no 1893 0.447784331319177 2646 4418754
SGTC_759 3486-0358 89.3 µM -0.131649338771435 0.443851231336034 no 1894 0.447630829211893 2637 875103
SGTC_3252 9135871 49.47 µM -0.131735440761916 0.443818712506273 no 1895 0.447596776061423 2782 17682838
SGTC_2045 5106652 78.05 µM -0.134299636564805 0.442850446429955 no 1896 0.446582820309349 2738 673349
SGTC_287 k060-0039 29.6 µM -0.135068539681551 0.442560167131347 no 1897 0.446278841948835 2760 5861974
SGTC_1303 1160-0052 261 µM -0.138528714392081 0.441254252303709 no 1898 0.444911288790427 2657 3562476
SGTC_1005 4092-0690 4.4 µM -0.141095686104934 0.440285855578226 no 1899 0.443897175774781 2714 1529343
SGTC_3228 9131799 49.47 µM -0.141281923786737 0.440215610754171 no 1900 0.44382361455048 2704 17015818
SGTC_2533 agelasine 13.65 µM -0.142662222592412 0.43969505070632 no 1901 0.443278476735188 2748 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2944 9067346 25.62 µM -0.143460100677711 0.439394189831388 no 1902 0.442963410148344 2795 6473075
SGTC_3148 9097893 49.47 µM -0.144238947964741 0.439100538777868 no 1903 0.442655893234937 2687 17174100
SGTC_1301 naphtanilide LB 4.81 µM -0.144506845738057 0.438999540240718 no 1904 0.442550125536811 2753 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_922 1866-0035 480 µM -0.144808354051849 0.438885875145122 no 1905 0.442431093087047 2672 3156169
SGTC_2844 9010103 25.97 µM -0.145380529738645 0.438670185490839 no 1906 0.442205218178534 2847 2480525
SGTC_2972 9093619 59.92 µM -0.146401913507289 0.438285205860188 no 1907 0.441802058413457 2682 25236256
SGTC_2827 7993847 71.43 µM -0.14657796174022 0.438218855708521 no 1908 0.441732574878121 2755 2985692
SGTC_2691 st077356 60.2 µM -0.147135300965114 0.438008813699459 no 1909 0.441512613474044 2811 2839272
SGTC_64 000l-0018 272.079 µM -0.148284640933712 0.437575722149999 no 1910 0.441059068057427 2663 6811119
SGTC_1229 0139-0193 12.2 µM -0.148829603394133 0.437370396795625 no 1911 0.440844045324356 2746 3090752
SGTC_1720 st037298 9.481 µM -0.149314387519474 0.437187758988897 no 1912 0.440652781468928 2760 597396
SGTC_2549 cedrol 20.94 µM -0.150807231605726 0.436625428419513 no 1913 0.440063890758726 2790 6708665 A sedative which affects the nervous system.
SGTC_1347 1493-0251 600 nM -0.151088586403301 0.436519460858393 no 1914 0.439952917936595 2792 3986378
SGTC_523 1934-0222 13.7 µM -0.151880806674937 0.436221108889642 no 1915 0.439640473356891 2688 1361595
SGTC_1268 0828-0275 2.46 µM -0.153244438233239 0.435707647195432 no 1916 0.439102757433322 2782 745337
SGTC_513 4245-1575 41.7 µM -0.154704003957414 0.43515818253857 no 1917 0.438527336649558 2807 719745
SGTC_152 4469-0003 551.229 µM -0.156551878461869 0.434462715772841 no 1918 0.437799015099024 2688 697280
SGTC_2089 5281248 129.67 µM -0.157538534463125 0.434091460435318 no 1919 0.43741022046238 2686 2737878
SGTC_367 0335-0881 7.1 µM -0.157725458201683 0.434021131989094 no 1920 0.437336569422597 2823 23828853
SGTC_1379 2144-0755 36.5 µM -0.159148536609437 0.433485779629246 no 1921 0.436775924403701 2778 5392327
SGTC_1619 st003326 88.7 µM -0.159468288238264 0.433365508007143 no 1922 0.436649970447648 2854 2849032
SGTC_1668 st014914 51.6 µM -0.159881136632642 0.433210228025183 no 1923 0.436487354073393 2684 2839556
SGTC_984 1492-0255 2.91 µM -0.160993649965045 0.43279184240245 no 1924 0.436049200998175 2831 1585198
SGTC_1313 1220-0047 237 µM -0.161683383939891 0.43253249025135 no 1925 0.43577759503029 2739 3528706
SGTC_2960 9079389 5.97 µM -0.16179206097531 0.432491628415176 no 1926 0.435734802548545 2798 16457355
SGTC_2903 5923464 63.88 µM -0.162567774995464 0.432199986142293 no 1927 0.435429380617524 2742 2876576
SGTC_172 1112-0046 2.638 µM -0.162867199180973 0.432087422633947 no 1928 0.435311498606046 2754 2802135 YIL048W NEO1
SGTC_2396 5342950 42.78 µM -0.167836847495121 0.430219978428896 no 1929 0.433355816773809 2780 1886677
SGTC_559 1550-0661 158 µM -0.167937616482159 0.430182128471277 no 1930 0.433316178346074 2779 5830875
SGTC_1018 4259-0013 28.1 µM -0.168790616665047 0.429861757804304 no 1931 0.432980669621301 2866 6801262
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.169300806368173 0.429670162297667 no 1932 0.43278002087401 2756 75037 A free radical scavenger.
SGTC_51 1013-0126 23.419 µM -0.169401864665219 0.429632213053445 no 1933 0.432740278456129 2814 1627850
SGTC_2334 9017922 200 µM -0.169617660170437 0.429551180059995 no 1934 0.432655416498429 2856 3163164
SGTC_1204 4049-0315 18.3 µM -0.171512258780868 0.428839870437667 no 1935 0.431910496074699 2977 588402
SGTC_2914 7968218 45.32 µM -0.171860531243238 0.428709139817685 no 1936 0.431773588170993 2811 2977111
SGTC_1319 1306-0155 43.7 µM -0.172240128512378 0.428566659750949 no 1937 0.431624375639478 2709 3122360
SGTC_79 0052-0007 94.094 µM -0.172595013988354 0.428433463560707 no 1938 0.431484885671184 2877 2801472
SGTC_1980 st071811 45.7 µM -0.1731236705252 0.428235062456248 no 1939 0.431277109742796 2856 4974850
SGTC_1511 0906-3109 28.5 µM -0.173922845023302 0.427935172303094 no 1940 0.430963049256763 2695 2882180
SGTC_676 falcarinol 140 µM -0.174551997569428 0.427699112143428 no 1941 0.430715834885451 2822 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_8 0354-0001 70 µM -0.175088022677806 0.427498014125444 no 1942 0.430505234708234 2717 4993152
SGTC_1801 st050089 28.441 µM -0.176104644042967 0.427116664849732 no 1943 0.430105866263975 2707 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1056 3448-1962 115 µM -0.17669669173979 0.426894610610297 no 1944 0.429873319798765 2817 715507
SGTC_164 4100-3994 89.624 µM -0.178309038638493 0.426289999166341 no 1945 0.429240140378742 2733 4615967
SGTC_1833 st055984 71 µM -0.178915891337344 0.426062481206465 no 1946 0.429001872320153 2769 676288
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.179903776589902 0.425692161233797 no 1947 0.428614055144018 2714 17037758
SGTC_2761 levamisole 97.89 µM -0.180433865196875 0.425493478512865 no 1948 0.428405985005142 2831 26879 An alkaline phosphatase inhibitor.
SGTC_3218 9131285 49.47 µM -0.1823979312609 0.424757491418436 no 1949 0.427635224595046 2824 17156417
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.182775287286408 0.424616116164666 no 1950 0.42748716991983 2678 4000243
SGTC_1410 3909-8106 77.9 µM -0.182791741081016 0.424609952022514 no 1951 0.427480714547612 2800 1039210
SGTC_1473 k844-0725 134 µM -0.183146482447263 0.424477058520156 no 1952 0.427341542406529 2750 54682906
SGTC_2063 5246145 200 µM -0.183399597534679 0.424382241585155 no 1953 0.427242245815853 2847 711240
SGTC_2175 5807670 165.306 µM -0.18341582927151 0.4243761613243 no 1954 0.427235878292079 2814 241186
SGTC_725 1497-0963 19 µM -0.18376787687836 0.424244291926119 no 1955 0.427097778729811 2844 3549977
SGTC_1936 st074407 74.3 µM -0.183819642890005 0.424224902215703 no 1956 0.42707747295779 2720 809813
SGTC_2906 7926292 26.41 µM -0.184301736359662 0.42404433592846 no 1957 0.426888375921201 2878 2966319
SGTC_952 1185-0122 232 µM -0.184890045034469 0.423824008741121 no 1958 0.426657639644566 2684 678600
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.185156340235407 0.423724286482753 no 1959 0.426553206182242 2796 6857784
SGTC_2975 9084847 53.72 µM -0.185386838432432 0.423637973434305 no 1960 0.426462815451678 2841 27211724
SGTC_1197 1601-0112 267 µM -0.186930463259297 0.42306003765886 no 1961 0.425857576971431 2725 7350313
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.187076319481629 0.423005437379959 no 1962 0.425800397342939 2718 165521
SGTC_1878 temozolomide 1 mM -0.187076939782265 0.423005205177817 no 1963 0.425800154171455 2753 5394 DNA alkylating agent.
SGTC_3124 9127567 49.47 µM -0.189180715839302 0.42221783610301 no 1964 0.424975590640946 2944 17592030
SGTC_1081 sertraline 6 µM -0.189373874618826 0.422145559122261 no 1965 0.424899899504888 2855 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2306 7482397 179.52 µM -0.189631120708261 0.422049305748379 no 1966 0.424799099436004 2892 891448
SGTC_1134 3477-0009 42.5 µM -0.190130458976539 0.421862482411065 no 1967 0.424603451292836 3011 3973534
SGTC_2162 5663267 200 µM -0.190556588023862 0.421703063610158 no 1968 0.424436502295697 2820 6456493
SGTC_556 4058-0063 51.5 µM -0.191420726204452 0.421379820977704 no 1969 0.424097991565705 2746 6615692
SGTC_655 k060-0012 42 µM -0.191459456423249 0.421365334651737 no 1970 0.424082821001948 2755 5994525
SGTC_429 1112-0049 25.5 µM -0.193881482832926 0.420459632452737 no 1971 0.423134341569695 2760 2836170
SGTC_3167 9103034 49.47 µM -0.194025819630904 0.420405671818949 no 1972 0.423077832457662 2722 5127859
SGTC_2323 6148992 148.28 µM -0.194366945915136 0.420278146943842 no 1973 0.422944284841676 2813 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2651 TUB2.036 5 µM -0.194616409967003 0.4201848938974 no 1974 0.422846627700788 2832 15992207 YFL037W TUB2
SGTC_2468 5987765 72.9 µM -0.194621065426716 0.42018315366598 no 1975 0.422844805283312 2795 26772094
SGTC_2890 9046729 58.44 µM -0.194993944333369 0.420043774952746 no 1976 0.422698844175826 2793 903329
SGTC_3185 9108267 49.47 µM -0.195981383280052 0.419674727816728 no 1977 0.422312368711975 2830 4910486
SGTC_1029 k015-0030 64.7 µM -0.198057522341597 0.418899018775572 no 1978 0.421500029347702 2863 2208316
SGTC_91 0417-1751 58.384 µM -0.198583779037737 0.418702443135651 no 1979 0.421294171674208 2725 6795624
SGTC_1964 st076914 61 µM -0.200250215165351 0.418080103956777 no 1980 0.42064244819777 2741 24208661
SGTC_351 caspofungin 25 nM -0.200694330219657 0.41791428143852 no 1981 0.420468796674186 2787 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_279 1273-0055 2.93 µM -0.200838234446665 0.41786055398311 no 1982 0.420412532617642 2832 2847562
SGTC_1828 st055811 49 µM -0.201344414949564 0.417671580821866 no 1983 0.420214637748275 2912 5877589
SGTC_503 tyrphostin 8 294 µM -0.20211152553541 0.417385230472479 no 1984 0.419914768863917 2869 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_707 0865-0008 204 µM -0.202677682644316 0.417173920992968 no 1985 0.419693483903772 2789 723043
SGTC_352 k048-0007 5.11 µM -0.203317629594781 0.416935099388491 no 1986 0.419443388437699 2812 6811911
SGTC_2279 7948423 32.93 µM -0.203973704669692 0.416690290752358 no 1987 0.41918702377448 2926 1247112
SGTC_1986 st071812 45 µM -0.205423382009893 0.416149471107556 no 1988 0.418620676798168 2785 11838594
SGTC_1162 k048-0130 20.1 µM -0.206185197292849 0.415865330270814 no 1989 0.418323125138367 2773 6797406
SGTC_858 0438-0351 2.77 µM -0.206244470553214 0.415843224452149 no 1990 0.418299976002072 2795 2799119
SGTC_703 3875-0075 71.8 µM -0.206380489296557 0.415792497598547 no 1991 0.418246855033359 2798 2850814
SGTC_836 0330-0104 1.35 µM -0.206700673196444 0.41567309369988 no 1992 0.418121815810029 2773 46494820
SGTC_521 r062-0005 13.8 µM -0.20838387661917 0.415045516940314 no 1993 0.417464622299363 2739 2832033
SGTC_2508 celastrol 40.54 µM -0.208970066630419 0.414827008754969 no 1994 0.417235803046714 2767 122724 Celastrol is a natural product and antioxidant.
SGTC_731 3966-0296 387 µM -0.209164022794023 0.414754715454631 no 1995 0.417160098431676 2782 660956
SGTC_2143 5623677 140.463 µM -0.209499507055926 0.414629677188826 no 1996 0.417029160080026 2763 5375313
SGTC_1430 4049-0248 69.1 µM -0.209830954921692 0.414506151821437 no 1997 0.416899806156933 2889 22774488
SGTC_1888 azatryptophan 97.5 µM -0.209900788484379 0.414480127037132 no 1998 0.416872553408947 2882 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2083 5306046 65.942 µM -0.209995900756666 0.414444682272401 no 1999 0.416835436214662 2804 539837
SGTC_2499 avocadenofuran 51.48 µM -0.212504274135434 0.413510158225666 no 2000 0.41585682182568 2772 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_450 aminopyrene 156 nM -0.213132879289384 0.413276040505448 no 2001 0.415611659902984 2862 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2682 pyrogallin 40.03 µM -0.21379252234265 0.413030396185226 no 2002 0.415354428225531 2824 822798 An ATP competetive kinase inhibitor.
SGTC_1039 k821-0043 94 µM -0.213924845052518 0.4129811246595 no 2003 0.415302832573368 2947 15992768
SGTC_326 k292-0812 17.5 µM -0.21661243312887 0.411980675288784 no 2004 0.414255197773454 2849 3579357
SGTC_3254 9136651 49.47 µM -0.217522133706212 0.411642170245307 no 2005 0.413900729856138 2799 16454030
SGTC_2384 9036245 200 µM -0.217661474521089 0.41159032649279 no 2006 0.413846441421882 2847 6462766
SGTC_1280 0880-0253 10.1 µM -0.218321844559524 0.411344647336465 no 2007 0.413589177726772 2828 6836607
SGTC_2899 9053889 58.44 µM -0.222267282689433 0.409877543339235 no 2008 0.412052909863052 2858 6470052
SGTC_2832 7992762 51.95 µM -0.222871460315616 0.409652991795272 no 2009 0.41181777455496 2783 2985177
SGTC_615 k087-0205 167 µM -0.223132591715516 0.409555947618445 no 2010 0.411716156600077 2820 9642773
SGTC_1563 conessine 56.1 µM -0.224519361219802 0.409040675910374 no 2011 0.411176601678506 2926 441082 An anti-amoebic, histamine inhibitor.
SGTC_1644 st010134 20.9 µM -0.224785039721387 0.408941977619956 no 2012 0.41107325242165 2848 3818134
SGTC_173 1273-0061 2.693 µM -0.225252312994761 0.408768401848033 no 2013 0.410891497533647 2907 2847414 YPL266W DIM1
SGTC_1624 st003710 6.25 µM -0.228034443873508 0.407735308489902 no 2014 0.409809731753537 2994 24207033
SGTC_2551 apiole 73.87 µM -0.229238280713769 0.407288484062695 no 2015 0.409341860472092 2794 10659 A possible DNA adduct former.
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.229335315929588 0.407252473044489 no 2016 0.409304153341733 2831 65057 A dermal irritant. YDR527W RBA50
SGTC_669 0108-0021 26.2 µM -0.22985570132615 0.407059364704279 no 2017 0.409101949947772 2818 17201
SGTC_519 k048-0011 62.8 µM -0.230216460276959 0.406925504945181 no 2018 0.408961785946953 2936 6836379
SGTC_1183 1254-0324 198 µM -0.230412613949414 0.406852726605084 no 2019 0.408885580155171 2951 5799357
SGTC_99 0109-0120 622.8 µM -0.230531884218737 0.406808475668121 no 2020 0.408839245284395 2888 759414
SGTC_1385 3091-4834 14.1 µM -0.230677906745179 0.406754300889919 no 2021 0.408782519261811 2925 4072814
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.233744075324748 0.40561715715422 no 2022 0.407591834125192 2967 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.234822986650384 0.405217212340864 no 2023 0.407173062880936 2831 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3183 9108214 49.47 µM -0.236502782666057 0.404594720934433 no 2024 0.406521274132516 2899 4974831
SGTC_3177 9107506 49.47 µM -0.236755695911111 0.404501018329263 no 2025 0.406423161974793 2949 8897194
SGTC_622 1348-1566 26.3 µM -0.23693513168844 0.404434541937988 no 2026 0.406353557354549 2919 7340407
SGTC_3344 9148862 3.898 µM -0.237007274782318 0.404407815534247 no 2027 0.406325573286424 2968 4905352
SGTC_3244 9134489 49.47 µM -0.23720183934501 0.404335738633703 no 2028 0.406250104720087 2895 16584271
SGTC_50 0929-0078 56.389 µM -0.238032627219701 0.404028007868879 no 2029 0.405927894251221 2852 1377751
SGTC_2746 daunorubicin 9.88 µM -0.239588629360687 0.403451811587797 no 2030 0.405324590264106 2808 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1622 st003707 19.4 µM -0.240018250831217 0.403292757215327 no 2031 0.405158053992278 2947 10140899
SGTC_2007 4011539 71.82 µM -0.242129332519494 0.402511425889198 no 2032 0.404339975123168 2823 45595301
SGTC_2424 5537928 59.2 µM -0.242234280607742 0.402472593739108 no 2033 0.404299316892868 2858 5382802
SGTC_1021 4476-0760 85.3 µM -0.242722606391452 0.402291919545038 no 2034 0.404110146845449 2857 746768
SGTC_3225 9130819 49.47 µM -0.243224349641323 0.402106302803027 no 2035 0.403915802427386 2967 4547121
SGTC_2976 9009005 19.48 µM -0.243704920725371 0.401928539266302 no 2036 0.403729681036766 3062 2993148
SGTC_2365 9042475 200 µM -0.244821599729539 0.401515557417239 no 2037 0.403297284302833 2949 6464479
SGTC_3020 9089140 49.47 µM -0.244846913227542 0.401506196989063 no 2038 0.403287483862354 2923 17217859
SGTC_182 3448-4371 550.524 µM -0.246055813190078 0.401059235715762 no 2039 0.402819513798879 2821 3491403
SGTC_2022 5136654 200 µM -0.246747722269788 0.400803477426846 no 2040 0.402551735581242 2993 1713771
SGTC_1518 st038567 90.8 µM -0.246990310775466 0.400713816715482 no 2041 0.402457861349662 2807 77966
SGTC_3079 9117512 49.47 µM -0.248369550055648 0.40020414942025 no 2042 0.401924245552871 2807 7185044
SGTC_7 0192-1582 4.227 µM -0.248485709680905 0.400161232951984 no 2043 0.401879312725583 2890 252616
SGTC_3226 9131256 49.47 µM -0.24864223208192 0.400103405913244 no 2044 0.40181876883421 2844 17178073
SGTC_1635 st007035 42.4 µM -0.249795009319061 0.399677581106255 no 2045 0.401372939708148 2868 3716403
SGTC_699 0375-0592 111 µM -0.25079697533154 0.399307561397586 no 2046 0.400985540097053 2934 762578
SGTC_3152 9099253 49.47 µM -0.255056123199093 0.397735698155284 no 2047 0.399339876099307 2949 25236131
SGTC_582 0987-0078 156 µM -0.255189881266489 0.397686360696916 no 2048 0.399288222995134 2898 1625765
SGTC_2605 digitonin 300 nM -0.255279034863999 0.397653476771276 no 2049 0.399253795695312 2952 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2741 miltefosine 3.04 µM -0.255943979445662 0.397408237742031 no 2050 0.398997047317758 2866 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2485 5633444 17.78 µM -0.256142491689012 0.397335032052484 no 2051 0.398920406241731 2954 5724239
SGTC_2602 kawain 100 µM -0.256194373937029 0.397315899945719 no 2052 0.398900376324382 2824 5369129
SGTC_3063 1327-0034 4 µM -0.25646217813839 0.397217148351922 no 2053 0.398796990744477 2934 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1817 st052116 64.4 µM -0.256528529093215 0.397192682754173 no 2054 0.398771377113116 3010 4361398
SGTC_3345 9148410 3.559 µM -0.257580474511244 0.396804852867302 no 2055 0.398365350209189 2996 4903596
SGTC_3231 9132313 49.47 µM -0.258313429267437 0.396534688348701 no 2056 0.398082511414087 2920 4905967
SGTC_2557 derrustone 83.84 µM -0.259382142349717 0.396140853540937 no 2057 0.397670203344748 2985 629853 An antioxidant.
SGTC_653 0203-0016 55.2 µM -0.260419069950193 0.395758833388554 no 2058 0.397270267297696 2913 295302
SGTC_224 benfluorex 43.875 µM -0.260549338387438 0.395710847554454 no 2059 0.397220031258611 2965 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1728 st035614 33.7865 µM -0.26061537347318 0.395686523396635 no 2060 0.397194566484559 2960 15945546
SGTC_1979 st071809 45.3 µM -0.262158183200543 0.395118342124876 no 2061 0.39659974556675 3000 4976333
SGTC_3273 9137859 49.47 µM -0.262890000831289 0.394848908432068 no 2062 0.396317681751325 2901 2377234
SGTC_1285 0929-0069 65.5 µM -0.263179858434135 0.394742205295954 no 2063 0.396205977188502 2898 1206237
SGTC_61 0978-8327 98.565 µM -0.264975355077218 0.394081418613987 no 2064 0.395514223607986 2927 6150059 YHR072W ERG7
SGTC_404 fumagillin 50 µM -0.265499290778394 0.393888654820113 no 2065 0.395312428067996 2923 12015870 A methionine aminopeptidase binder.
SGTC_1548 st061468 90.8 µM -0.266149790964893 0.393649362233682 no 2066 0.395061924868771 2994 390799
SGTC_571 k831-0106 44.2 µM -0.266704257628404 0.393445428176665 no 2067 0.394848437757876 2948 4783639
SGTC_2553 4-methylesculetin 85.09 µM -0.26931055487346 0.392487218799116 no 2068 0.393845355263541 2932 5319502
SGTC_379 3970-0972 5.9 µM -0.273446704890142 0.39096789578793 no 2069 0.39225492746839 2926 2898042 YBL034C STU1
SGTC_971 1315-0384 26.7 µM -0.273584054937744 0.390917471688736 no 2070 0.392202144482933 2910 6769120
SGTC_1757 st041620 31.8375 µM -0.275042792951763 0.390382051524234 no 2071 0.391641680812261 2960 5289815
SGTC_3313 9133968 57.047 µM -0.275538861066442 0.390200020299643 no 2072 0.391451136994449 2851 1494643
SGTC_1252 0493-0875 34.8 µM -0.276346174179071 0.389903829811332 no 2073 0.391141097126954 2868 3960963
SGTC_314 1671-0008 2.74 µM -0.276692059565771 0.389776949449466 no 2074 0.391008284738524 2883 3913060
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.279380295081232 0.388791231387443 no 2075 0.389976495760806 3020 5024745
SGTC_1346 1488-2224 62.4 µM -0.280463986003508 0.388394067271779 no 2076 0.389560776061419 3003 3722427
SGTC_2685 mycophenolic acid 18.85 µM -0.281066403477133 0.388173336477469 no 2077 0.38932973450591 2930 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1269 0831-0796 3.05 µM -0.281297983127354 0.388088493366264 no 2078 0.389240928558099 3035 927758
SGTC_979 1426-2828 121 µM -0.282411663198586 0.387680552558991 no 2079 0.388813936446696 3046 747872
SGTC_1505 k297-0037 20.6 µM -0.283150710015573 0.387409908237083 no 2080 0.388530655226024 2923 4089396
SGTC_409 arachidonic acid 100 µM -0.283432651983385 0.387306673446728 no 2081 0.388422600735978 2928 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1997 st073024 93.8 µM -0.283965256022529 0.38711167894436 no 2082 0.388218503369865 3036 686268
SGTC_961 1252-1571 372 µM -0.287013076749573 0.385996374345854 no 2083 0.387051153747984 3091 6813498
SGTC_1772 st048439 82.2 µM -0.287071481339473 0.385975011221617 no 2084 0.387028794068527 2996 2927068 YDL195W SEC31
SGTC_1660 st012960 28.1 µM -0.289805914198656 0.384975203466008 no 2085 0.385982361536982 3006 24207266
SGTC_607 4491-0986 66.8 µM -0.292621936350432 0.383946362499873 no 2086 0.384905572289834 3062 698981 YDR232W HEM1
SGTC_2839 9003951 25.97 µM -0.293024027052701 0.383799524144679 no 2087 0.384751893214435 3030 2990634
SGTC_846 0335-0850 148 µM -0.293397960544603 0.383662983411522 no 2088 0.384608992073295 3003 6819598
SGTC_2472 5377652 49.4 µM -0.293532527592396 0.383613850176601 no 2089 0.38455757022672 2970 1610903
SGTC_3266 9136860 49.47 µM -0.294243828888749 0.383354170348204 no 2090 0.384285795796621 3025 4871271 YPR165W RHO1
SGTC_250 brefeldin a 552.239 µM -0.29457917035782 0.383231763017221 no 2091 0.384157688044876 2904 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1217 1183-1422 255 µM -0.296524416208451 0.382521933938808 no 2092 0.383414811746793 3068 2849664
SGTC_2873 9040596 71.43 µM -0.297293897051909 0.382241255632519 no 2093 0.383121070290865 3039 6463863
SGTC_640 3381-0960 37.1 µM -0.297827551105335 0.38204663458625 no 2094 0.382917392751731 2993 1745025
SGTC_692 k241-0027 77.8 µM -0.298197736631323 0.381911647223337 no 2095 0.382776124582257 3106 3600480
SGTC_2393 9031399 185.94 µM -0.298768401885767 0.381703583483107 no 2096 0.382558380992564 3082 1526623 YDL150W RPC53
SGTC_688 0527-0193 473 µM -0.300231748910883 0.381170205534768 no 2097 0.382000194673422 2950 4007154
SGTC_415 dibenzyl ketone 100 µM -0.300663455906303 0.381012894948772 no 2098 0.381835569010713 3010 7593
SGTC_884 0851-0618 334 µM -0.301549045985915 0.380690254553863 no 2099 0.381497928034853 3075 9642473
SGTC_3318 9139014 38.6185 µM -0.301896403891001 0.38056372689053 no 2100 0.38136551860863 2928 16643984
SGTC_2834 9001755 58.44 µM -0.303192178853204 0.380091844177053 no 2101 0.380871704523393 2986 2989575
SGTC_620 0109-0052 432 µM -0.303226680928098 0.380079281983063 no 2102 0.380858558583578 3094 493037
SGTC_2569 tetrandrine 100 µM -0.307861412077708 0.378392932896603 no 2103 0.379093894650474 2996 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.310384237605907 0.377475971904405 no 2104 0.378134389618067 2972 97141
SGTC_189 3970-0742 2.116 µM -0.311103815220107 0.377214556281525 no 2105 0.377860850424518 2985 2891807
SGTC_2465 5809242 33.21 µM -0.311268759790609 0.377154641428019 no 2106 0.377798157255532 2918 2731748
SGTC_200 k038-0079 37.545 µM -0.311421897402299 0.377099018009317 no 2107 0.377739954630983 2952 3436683
SGTC_700 3453-2283 142 µM -0.311422999758416 0.377098617615191 no 2108 0.377739535671344 3140 565664
SGTC_2046 4110841 106 µM -0.311515231720686 0.377065117896333 no 2109 0.377704482654081 3118 44119630 YMR134W ERG29
SGTC_2939 9044578 71.43 µM -0.313580448927855 0.376315249804963 no 2110 0.376919855285693 2921 2653634
SGTC_1438 4092-1045 4 µM -0.313601378507222 0.376307652782761 no 2111 0.376911906213033 2959 1351342
SGTC_3052 9092717 49.47 µM -0.313741105292225 0.376256935959079 no 2112 0.376858839194135 3132 25237534
SGTC_2359 9039622 200 µM -0.313889282878637 0.376203154070747 no 2113 0.376802565175912 2923 6463596
SGTC_941 3237-0776 460 µM -0.313940648979662 0.376184511016534 no 2114 0.376783058268959 3145 760008
SGTC_167 3672-0051 66.205 µM -0.314245879307299 0.376073735246782 no 2115 0.376667149797768 2894 3237971
SGTC_2624 nerol 100 µM -0.314781045590933 0.375879534579221 no 2116 0.376463952055217 2927 637566 A natural product oil.
SGTC_727 3032-0951 202 µM -0.316830314124547 0.375136188850652 no 2117 0.375686180468185 3018 3652836
SGTC_1257 0669-0121 16 µM -0.317153588772646 0.375018967397994 no 2118 0.3755635320615 3046 4307855
SGTC_178 4092-0806 87.505 µM -0.319908408635254 0.374020521450819 no 2119 0.374518881708556 3051 2169044
SGTC_916 4466-0038 42 nM -0.32137252681305 0.373490215566094 no 2120 0.373964050107774 3184 5722064 YGL116W CDC20
SGTC_2 0422-0095 29 µM -0.321895704097477 0.373300777963262 no 2121 0.373765853880446 3012 6790840
SGTC_2402 5553605 200 µM -0.324176581789912 0.372475251761587 no 2122 0.372902175289374 3169 6758546
SGTC_3024 9090631 49.47 µM -0.324695826249276 0.372287401449508 no 2123 0.372705646914212 3108 25236383
SGTC_1000 4048-0884 8.67 µM -0.325190863260621 0.37210833710882 no 2124 0.372518311644225 3099 13040088
SGTC_551 k048-0028 34.9 µM -0.325432372462658 0.372020988652332 no 2125 0.372426929032532 3128 6836383
SGTC_2466 5983409 37.09 µM -0.325648152849651 0.371942951301251 no 2126 0.372345287803074 3000 2879657
SGTC_1496 4469-0713 57.4 µM -0.326596855234502 0.37159991388354 no 2127 0.371986411191282 3096 746691
SGTC_2910 7948405 25.97 µM -0.327137615550231 0.371404428165543 no 2128 0.371781901267269 3151 2971328
SGTC_2780 5215298 71.43 µM -0.327240247557317 0.37136733027416 no 2129 0.371743090993015 3123 2834131
SGTC_1631 benzylvanillin 81.9 µM -0.327639365070014 0.371223074574156 no 2130 0.371592177173974 3121 75506
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.328662840817424 0.370853235638367 no 2131 0.37120527202738 2998 689007
SGTC_2031 5180455 200 µM -0.330045205615107 0.370353899450532 no 2132 0.37068290247477 2987 29949
SGTC_2211 7117706 200 µM -0.330317428659732 0.370255593072624 no 2133 0.370580062579891 3081 822771
SGTC_1074 carmofur 3.8 µM -0.331676353401647 0.369764979073386 no 2134 0.370066829051606 2999 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3106 9121286 49.47 µM -0.332024565030702 0.36963929794736 no 2135 0.369935354997751 3197 15943471
SGTC_2173 5763948 167 µM -0.332138542497278 0.369598162723965 no 2136 0.369892323895845 2980 2867177
SGTC_3332 9141069 11.198 µM -0.333024101151331 0.369278609613251 no 2137 0.369558045233577 2958 17332883
SGTC_2966 9084041 48.03 µM -0.333785962505379 0.36900376482394 no 2138 0.369270538415003 2900 17741380
SGTC_1741 st038134 10.228 µM -0.335782522508427 0.368283815160818 no 2139 0.368517435377093 3229 1272587
SGTC_217 ketoconazole 989 nM -0.337063886560333 0.367822004988789 no 2140 0.368034370205734 3076 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2044 5102272 200 µM -0.337358948538439 0.367715690171723 no 2141 0.367923163451103 3088 592666
SGTC_1694 st024011 44.9 µM -0.337744353012179 0.367576838999127 no 2142 0.367777923927453 3092 2787533
SGTC_3165 9101544 49.47 µM -0.337862338028287 0.367534335536919 no 2143 0.367733465099318 3100 5002184
SGTC_2857 9024691 58.44 µM -0.338860636599195 0.367174768885 no 2144 0.367357359639317 3096 16478292
SGTC_2149 5554786 194.827 µM -0.339727169804201 0.366862755815175 no 2145 0.3670309994352 3014 745063 YPR165W RHO1
SGTC_3135 9127742 49.47 µM -0.340041462138778 0.366749610128028 no 2146 0.366912652037959 3050 3643468
SGTC_1693 xanthone 101.9 µM -0.342784550494915 0.365762586847869 no 2147 0.365880274746949 3029 7020 An insecticide.
SGTC_2225 6654152 15.4 µM -0.343570024879034 0.365480119209167 no 2148 0.365584835280389 3067 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2239 6685329 187.64 µM -0.343876216066254 0.365370028301018 no 2149 0.365469689569993 3136 805680
SGTC_142 0335-0849 62.6745 µM -0.344735878882882 0.365060996223203 no 2150 0.365146471139142 3121 3889043 YPR107C YTH1
SGTC_1905 st060207 84.5 µM -0.345664352631202 0.364727326375329 no 2151 0.364797488567707 2980 1948547
SGTC_2160 5660466 132.927 µM -0.34609412444544 0.36457291198491 no 2152 0.364635989456471 3100 2859134
SGTC_2440 5628896 157.78 µM -0.346677816058607 0.364363230337063 no 2153 0.364416689026117 3014 5522048
SGTC_1444 4112-3581 28 µM -0.34849507301607 0.363710670679048 no 2154 0.36373420668389 3037 2877249
SGTC_1468 k284-1086 134 µM -0.348583597189835 0.363678892570162 no 2155 0.36370097189129 3045 15996457
SGTC_886 0866-0150 153 µM -0.348611285900771 0.363668953162761 no 2156 0.3636905768784 3182 271463
SGTC_1101 ebselen 5.29 µM -0.348649194952335 0.363655345111874 no 2157 0.363676345064764 3165 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_541 4513-1321 94 µM -0.350676644975688 0.362927810999313 no 2158 0.362915474411523 3023 747515
SGTC_1416 3966-0321 25.3 µM -0.351557338446921 0.36261193511893 no 2159 0.362585132074999 3066 582530 YLR208W SEC13
SGTC_1264 0783-0040 158 µM -0.35159947513694 0.362596824411153 no 2160 0.362569329440972 2970 2855798
SGTC_1086 cerivastatin 2.18 µM -0.353043568057679 0.362079085367864 no 2161 0.362027889130539 3088 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2188 6126565 140.678 µM -0.353759970748364 0.361822332811951 no 2162 0.361759387370558 3136 874518
SGTC_2406 ethylparaben 405.7 µM -0.354008382334495 0.361733318752034 no 2163 0.361666300658045 2915 8434 A possible steroid mimic.
SGTC_1024 4507-0395 26 µM -0.354690267573067 0.361489015257795 no 2164 0.361410821431916 3195 4201836
SGTC_1168 k815-0004 80.5 µM -0.35600331534237 0.361018740137382 no 2165 0.360919041173066 2994 642433
SGTC_476 mead acid 10 µM -0.356523842166015 0.360832368744491 no 2166 0.360724150059766 3012 5312531 An omega 9 fatty acid.
SGTC_2416 tofa 880 nM -0.3566304170466 0.360794214344923 no 2167 0.36068425168127 3030 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3012 9080433 71.4286 µM -0.35734021383263 0.360540138508268 no 2168 0.360418564155538 3141 17688859
SGTC_401 neomycin 50 µM -0.357374516509353 0.360527861226605 no 2169 0.360405725857817 3068 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3343 9148379 18.9835 µM -0.357654872441284 0.360427524338773 no 2170 0.360300804293247 3187 1955036
SGTC_3067 9117431 49.47 µM -0.357666315728912 0.360423429092281 no 2171 0.360296521933325 3058 17150885
SGTC_848 0368-0089 85.6 µM -0.358038453115688 0.360290259807123 no 2172 0.360157268518341 3148 762535
SGTC_2992 9074591 71.4286 µM -0.358241945400295 0.360217447302824 no 2173 0.360081129766733 3155 17741321
SGTC_155 k072-0202 43.6 µM -0.360289743546567 0.359484997928494 no 2174 0.359315234248681 3113 5857737
SGTC_1065 prochlorperazine maleate 2.48 µM -0.362251450800167 0.358783825032195 no 2175 0.358582067234564 3090 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1893 st059353 36.1 µM -0.364117446370637 0.358117303659744 no 2176 0.357885154726383 3106 3112488
SGTC_2459 5811157 9.22 µM -0.364166961667325 0.358099622998295 no 2177 0.35786666817824 3047 2870684 YBR192W RIM2
SGTC_2376 9072922 81.32 µM -0.364372893276979 0.358026093288459 no 2178 0.357789787137872 3167 17087968
SGTC_1214 0358-0031 63.7 µM -0.365746786640323 0.357535667352457 no 2179 0.357277015336461 3278 4301366
SGTC_209 4077-0173 175.592 µM -0.365886121174936 0.357485943519838 no 2180 0.357225026532209 3118 15993494
SGTC_1386 3228-0095 33.8 µM -0.367085253045176 0.357058113563845 no 2181 0.356777713489841 3168 870181
SGTC_564 3555-0129 330 µM -0.368015520130411 0.356726333744215 no 2182 0.356430830844247 3092 563260
SGTC_853 0419-0306 21 µM -0.368298753947792 0.356625339891346 no 2183 0.356325240768048 3039 762713
SGTC_45 0kpi-0036 14.9 µM -0.369060905993038 0.356353626117197 no 2184 0.356041163830709 3204 2795021
SGTC_100 0086-0128 49.5915 µM -0.369105035745199 0.356337895711764 no 2185 0.356024717793415 3087 93297
SGTC_1613 st002381 52.1 µM -0.369441056438441 0.356218126449007 no 2186 0.355899500206854 3126 551167
SGTC_102 gallobenzophenone 83.616 µM -0.369595773528771 0.356162984756628 no 2187 0.355841850350102 3230 70837
SGTC_827 3253-0474 693 µM -0.370443230805723 0.355861001515192 no 2188 0.355526133852225 3185 5402065
SGTC_2515 chrysin 20.77 µM -0.370450743069698 0.355858324996297 no 2189 0.355523335634008 3145 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_610 4215-0184 155 µM -0.371510373345016 0.355480864178599 no 2190 0.355128715558234 3118 5605015
SGTC_718 1130-0073 349 µM -0.373418236331496 0.354801603905526 no 2191 0.354418594438692 3224 6740020
SGTC_2607 solasodine 47.35 µM -0.374333405363311 0.354475938033769 no 2192 0.354078140903925 3079 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2677 mitomycin C 100 µM -0.37524383477518 0.354152064302277 no 2193 0.353739566270234 3081 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_918 glabranin 770.725 nM -0.375742180592757 0.35397482874202 no 2194 0.353554288120625 3103 124049 Also referred to as licorice root.
SGTC_1312 1218-2183 165 µM -0.377846580268821 0.353226753025487 no 2195 0.352772284147048 3125 6744073
SGTC_2198 6589944 200 µM -0.378251605632219 0.353082838845671 no 2196 0.352621846214107 3110 5290268
SGTC_153 4077-0274 519.67 µM -0.382400473565104 0.351609870515069 no 2197 0.351082169582501 3358 3121976
SGTC_1341 1486-1360 280 µM -0.383685466669135 0.351154110995209 no 2198 0.350605792809801 3073 3976547
SGTC_2414 st077232 92.9 µM -0.383713823774938 0.351144055748411 no 2199 0.350595282818027 3014 729801
SGTC_502 l-744,832 89.3 µM -0.383958109435455 0.35105743794546 no 2200 0.350504747980617 3183 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1550 gossypolone 36.6 µM -0.384118811885594 0.351000460952118 no 2201 0.350445194590951 3076 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2482 5981709 142.65 µM -0.384354004990476 0.350917079364256 no 2202 0.350358042953936 3106 877755
SGTC_2078 5212016 200 µM -0.384362107530619 0.350914206947637 no 2203 0.350355040669374 3138 1899708
SGTC_781 4335-2806 94.4 µM -0.385136264430068 0.350639801325379 no 2204 0.350068230650056 3217 845254
SGTC_2327 6189656 200 µM -0.386499034814891 0.350156946669411 no 2205 0.34956355864366 3181 5349088
SGTC_2470 5664817 21.68 µM -0.387979142426067 0.349632791575375 no 2206 0.349015734457282 3115 2859561
SGTC_85 0868-0259 160.055 µM -0.388823452847129 0.349333921579441 no 2207 0.348703375234052 3137 83173
SGTC_1973 st070275 50.2 µM -0.390412888310825 0.348771544866646 no 2208 0.348115629519582 3155 17118334
SGTC_1806 st050005 60.3 µM -0.391030245489458 0.34855319999665 no 2209 0.347887439766313 3100 5194765
SGTC_1396 3511-0007 98.6 µM -0.391420370927624 0.348415247567513 no 2210 0.347743268612164 3174 X1396
SGTC_531 3788-1495 174 µM -0.391644967055447 0.348335837123207 no 2211 0.347660278924804 3035 2896655
SGTC_3114 9122766 49.47 µM -0.395504077737453 0.346972412544151 no 2212 0.346235456411757 3150 17176985
SGTC_2249 haloperidol 116.36 µM -0.396617589638146 0.346579375644384 no 2213 0.345824739784409 3098 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_432 NS 1619 61.3 µM -0.397709548089271 0.346194106797787 no 2214 0.345422149217744 3244 4552 A K+/calcium channel activator.
SGTC_1910 st062352 60.4 µM -0.397891368816623 0.346129971574529 no 2215 0.345355131297474 3024 2245730
SGTC_2729 fluphenazine 10.66 µM -0.398234031645473 0.346009113099854 no 2216 0.345228841219958 3091 3372 An atypical antipsychotic.
SGTC_2245 6637752 200 µM -0.399171862177199 0.345678416968397 no 2217 0.344883287305414 3199 681890
SGTC_284 0988-0104 32.6 µM -0.401075008218732 0.345007695053498 no 2218 0.344182450143902 3171 4666532
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.401308155327836 0.344925560910052 no 2219 0.344096630000877 3107 5355888
SGTC_1209 2323-2347 50.3 µM -0.40176686191836 0.344763986960138 no 2220 0.343927806120538 3204 5412760
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.402404796250287 0.344539329233517 no 2221 0.343693070398174 3078 442882
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.402922198173927 0.34435715898444 no 2222 0.34350273029302 3218 688801
SGTC_489 paxilline 115 µM -0.404539766360915 0.343787868037301 no 2223 0.342907920782561 3179 105008 A toxic potassium channel blocker.
SGTC_2134 5324836 1.464 µM -0.404697930724083 0.343732222260466 no 2224 0.342849781705234 3095 699272
SGTC_809 3998-0021 90 µM -0.406157517531456 0.343218866740591 no 2225 0.34231343315025 3255 715485
SGTC_810 3825-7150 143 µM -0.406219248042782 0.3431971616902 no 2226 0.342290756284267 3280 22330411 YGL099W LSG1
SGTC_70 0141-0289 43.283 µM -0.407147922397853 0.342870693182566 no 2227 0.34194967397914 3151 352408
SGTC_2103 5378138 10 µM -0.408804672159414 0.342288566618014 no 2228 0.341341505450427 3203 244142
SGTC_490 phenamil 164 µM -0.410692736749004 0.341625620388281 no 2229 0.340648926735402 3169 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2114 5491910 81.25 µM -0.411112189628744 0.341478406305319 no 2230 0.340495136089035 3240 2849228
SGTC_900 1112-0045 141 µM -0.411168685928178 0.341458579815653 no 2231 0.340474423982706 3160 56211 YIL048W NEO1
SGTC_161 4065-0411 162.148 µM -0.411523326612441 0.341334134227769 no 2232 0.340344420165402 3222 1906281 YLR208W SEC13
SGTC_2340 7987427 183.45 µM -0.411944632413302 0.341186317863497 no 2233 0.340190002975716 3251 2239331
SGTC_371 0195-0006 7.36 µM -0.413468290365397 0.340651941597308 no 2234 0.339631775051635 3084 3928593
SGTC_1746 st038117 42 µM -0.413473556682676 0.340650095151901 no 2235 0.339629846221495 3204 2898218
SGTC_1055 3448-0672 86 µM -0.415729874337198 0.339859350036891 no 2236 0.338803839090295 3275 748378
SGTC_1368 1852-0141 284 µM -0.416105412717619 0.33972780777263 no 2237 0.338666434691152 3232 2838987
SGTC_1667 st014849 34.6 µM -0.416114197570281 0.339724730878864 no 2238 0.338663220689659 3165 5348460
SGTC_3223 9129970 49.47 µM -0.417246946644873 0.339328075165653 no 2239 0.338248894799021 3090 17248386
SGTC_2575 plumbagin 510 nM -0.421540033694993 0.337826379718185 no 2240 0.336680392129838 3083 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1048 3161-0300 24.5 µM -0.421567081523951 0.337816926701214 no 2241 0.336670519023714 3206 2165101
SGTC_280 3448-3607 3.04 µM -0.422288000810552 0.337565008437601 no 2242 0.336407407704775 3247 626179
SGTC_467 ro 31-8220 72.8 µM -0.423002690910012 0.3373153387343 no 2243 0.336146648882761 3155 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_335 4077-0256 27.6 µM -0.423748518462211 0.337054867844724 no 2244 0.335874613427872 3199 3121989
SGTC_2912 7964298 10.93 µM -0.424201632011688 0.336896661768891 no 2245 0.33570938535443 3236 2975850
SGTC_656 4090-1979 187 µM -0.424870097138575 0.336663317671219 no 2246 0.335465687213923 3285 22330961
SGTC_2281 7943571 200 µM -0.425340401545397 0.336499184090566 no 2247 0.335294272751315 3367 1244024
SGTC_1097 itavastatin 7.23 µM -0.426776903272238 0.335998046085406 no 2248 0.334770915407088 3173 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3161 9100388 49.47 µM -0.427182015427168 0.335856771293203 no 2249 0.334623379779973 3173 25236368
SGTC_1719 st032227 49.2 µM -0.427212873067505 0.335846011256237 no 2250 0.334612142947244 3146 3125804
SGTC_2962 9082311 13.18 µM -0.42742616619446 0.335771639776348 no 2251 0.334534476147228 3110 16459453
SGTC_1180 1193-0155 285 µM -0.427568876822367 0.335721882736303 no 2252 0.334482514629566 3268 2921347
SGTC_2778 tioconazole 65.09 nM -0.42992584107427 0.334900528094899 no 2253 0.33362479363537 3200 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_934 2950-0684 338 µM -0.430641169951544 0.334651406269852 no 2254 0.333364650524237 3321 1121253
SGTC_1464 k208-0027 110 µM -0.431024007853989 0.334518108285198 no 2255 0.333225457063356 3344 X1464
SGTC_3257 9139206 32.98 µM -0.431320222385307 0.334414985473045 no 2256 0.333117774170896 3257 4910041
SGTC_2798 7813637 45.45 µM -0.431522613134812 0.334344533239633 no 2257 0.333044206955913 3280 956368
SGTC_210 3551-0445 56.827 µM -0.437175747684668 0.332379041999201 no 2258 0.330991948320379 3293 2865180 YOR207C RET1
SGTC_1455 4262-0120 131 µM -0.438666127532982 0.331861628361582 no 2259 0.330451737043564 3343 1529587
SGTC_422 cantharidin 155 µM -0.438809235120833 0.331811962698377 no 2260 0.330399884043182 3123 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1085 doxorubicin 7.67 µM -0.439439801868248 0.331593158952233 no 2261 0.330171445938698 3294 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1333 1482-0047 286 µM -0.43961153475034 0.331533578386921 no 2262 0.330109242497819 3301 3811116
SGTC_572 0960-0087 17.7 µM -0.439692016010913 0.331505657891722 no 2263 0.330080092961843 3215 6796365
SGTC_27 0485-0001 32.618 µM -0.440238097436744 0.33131623649149 no 2264 0.329882334790497 3229 2054479
SGTC_2479 5617353 43.85 µM -0.440468623932224 0.331236285813533 no 2265 0.329798866089139 3328 2731746
SGTC_2037 5169046 200 µM -0.442986610401092 0.33036350499412 no 2266 0.328887709790175 3285 5718022
SGTC_603 3794-0023 45.9 µM -0.443239101313035 0.330276037745182 no 2267 0.32879639961593 3264 3802260
SGTC_3107 9121808 49.47 µM -0.443702819979904 0.330115421681057 no 2268 0.328628728191045 3274 662681
SGTC_1663 st014140 55.4 µM -0.443879983816051 0.330054066535406 no 2269 0.328564678385398 3258 4207120
SGTC_1009 4106-0057 9.87 µM -0.444655288759631 0.329785617737672 no 2270 0.328284442692927 3326 2928005
SGTC_2374 9071832 200 µM -0.445665990216002 0.329435794689186 no 2271 0.327919267464879 3303 17381698
SGTC_581 0958-0271 211 µM -0.445779668909946 0.32939645765605 no 2272 0.327878204646867 3206 4591145
SGTC_2618 avocadyne 43.43 µM -0.445947638291836 0.329338337492749 no 2273 0.327817534850885 3196 3015189
SGTC_54 0159-0055 9 µM -0.446067459689764 0.329296879842012 no 2274 0.327774258670247 3395 3319099
SGTC_215 1287-0124 461.5 µM -0.446161288036027 0.329264417132356 no 2275 0.327740372076938 3209 5560863
SGTC_2612 dictamnine 15.46 µM -0.446713908587946 0.329073247722635 no 2276 0.327540819090924 3233 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1322 1348-1070 12 µM -0.447316199837891 0.328864946503215 no 2277 0.327323385960362 3290 6758089
SGTC_294 k038-0071 157 µM -0.449876765504496 0.327979973894627 no 2278 0.326399650878092 3248 24152826
SGTC_2688 kanamycin b 96.69 µM -0.451789519052962 0.327319524836605 no 2279 0.325710310466259 3383 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_3136 9095672 49.47 µM -0.45206576456989 0.327224185427063 no 2280 0.32561080304848 3217 17217380
SGTC_41 0478-0632 82.643 µM -0.452294403334313 0.327145284852888 no 2281 0.325528453632799 3321 3750424
SGTC_3057 9095946 49.47 µM -0.452474754156655 0.327083053334246 no 2282 0.325463502217777 3234 24540043
SGTC_435 c-PAF 6.7 µM -0.452856010814895 0.326951513447536 no 2283 0.325326214166893 3287 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1047 2043-3044 82 µM -0.452861659499297 0.326949564719072 no 2284 0.325324180290402 3210 669592
SGTC_2212 7123476 200 µM -0.454008336032246 0.326554072825352 no 2285 0.324911413467256 3226 1085715
SGTC_2219 9098279 200 µM -0.454159535889996 0.326501938110016 no 2286 0.324857002383505 3286 902349
SGTC_2325 6158266 200 µM -0.454453751496954 0.326400500327516 no 2287 0.324751136075139 3241 3623240
SGTC_2445 5742597 35.57 µM -0.455290413541452 0.326112111497841 no 2288 0.324450161029375 3168 1774255
SGTC_1998 st075797 76.8 µM -0.455812908033327 0.325932065726032 no 2289 0.324262260590543 3321 24208315
SGTC_2285 7945142 200 µM -0.456022902569346 0.325859715382003 no 2290 0.324186754569002 3297 2970608
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.45740674257511 0.325383098968276 no 2291 0.323689359451247 3275 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_561 1550-0330 72.9 µM -0.458287785326629 0.325079802552426 no 2292 0.32337284923067 3206 6812934
SGTC_2935 9038016 29.96 µM -0.459086787796199 0.32480484844279 no 2293 0.323085922046765 3362 6463195
SGTC_2803 7707263 71.43 µM -0.459278856797637 0.324738767546783 no 2294 0.323016964453631 3170 2199229
SGTC_299 1273-0059 1.44 µM -0.460329332305985 0.324377451496986 no 2295 0.322639925037676 3281 2848077
SGTC_1306 1185-0270 9.02 µM -0.461278182630571 0.324051231967016 no 2296 0.322299517870076 3304 1548076
SGTC_376 3970-0862 59.1 µM -0.461509986078182 0.323971557290748 no 2297 0.322216379276404 3306 3135186
SGTC_3322 9139058 2.11 µM -0.462385274105602 0.323670779062745 no 2298 0.321902528812899 3354 4908926 YPR165W RHO1
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.464085688374259 0.323086789123475 no 2299 0.32129317747893 3377 165506
SGTC_3046 9092212 49.47 µM -0.464666654068999 0.322887362191128 no 2300 0.321085095828779 3277 25236637
SGTC_1220 1838-0075 193 µM -0.465201278073086 0.322703887861618 no 2301 0.320893661778416 3230 5529645
SGTC_2059 5238311 157 µM -0.465271850627927 0.322679671723208 no 2302 0.320868395256791 3167 703021
SGTC_412 gemfibrozil 100 µM -0.465309220123516 0.322666849126839 no 2303 0.320855016494163 3299 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_322 k048-0136 19.3 µM -0.465534188629237 0.322589660131863 no 2304 0.320774479776415 3286 6823282
SGTC_1925 st057770 10.1 µM -0.465713819694189 0.322528032365844 no 2305 0.32071017951367 3202 5989122
SGTC_1669 st015249 58.4 µM -0.467141856053808 0.322038275700909 no 2306 0.320199194868669 3332 722793
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.467554374584689 0.321896856588286 no 2307 0.320051649537441 3251 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_203 k066-0004 30.888 µM -0.470787971209348 0.320789213658096 no 2308 0.318896077656882 3337 6795412
SGTC_2222 6885208 172.143 µM -0.471530020906117 0.320535254841744 no 2309 0.31863114325193 3268 609514
SGTC_789 1309-1135 70.6 µM -0.47172191261781 0.320469595557191 no 2310 0.318562647128551 3317 3092424
SGTC_2322 7413319 38.22 µM -0.473600933305867 0.319826951153062 no 2311 0.317892254903472 3320 1840400
SGTC_1957 st077035 62.4 µM -0.474439682038931 0.319540264795798 no 2312 0.317593200653249 3343 705593
SGTC_1978 st071761 42 µM -0.474695181034519 0.319452956033524 no 2313 0.31750212661165 3224 5147680
SGTC_3149 9097855 49.47 µM -0.475218323595735 0.319274219712644 no 2314 0.31731568399426 3343 25236625 YMR079W SEC14
SGTC_2383 9036125 200 µM -0.476519456269349 0.318829858309803 no 2315 0.316852174780477 3217 79580
SGTC_2272 7805186 180 µM -0.478149444643206 0.318273553828834 no 2316 0.31627192106191 3350 2956062 YPR165W RHO1
SGTC_2019 4016004 108 µM -0.478661943266799 0.318098725946524 no 2317 0.316089571871099 3282 45595336
SGTC_1718 roemerine 11.9335 µM -0.48028853871217 0.317544116446391 no 2318 0.31551111872334 3312 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2918 7977171 22.06 µM -0.480733780177908 0.317392376700048 no 2319 0.315352859755552 3281 2236483
SGTC_1556 plumbagin 1.48 µM -0.482648410186865 0.316740214461975 no 2320 0.31467269988789 3311 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2717 st081029 62.2815 µM -0.484745272021688 0.316026633276267 no 2321 0.313928524196665 3348 5292846
SGTC_1482 3346-2049 8.48 µM -0.485922949423383 0.315626159078764 no 2322 0.313510898195791 3336 3826804
SGTC_743 1275-0778 158 µM -0.486379851617709 0.315470845789224 no 2323 0.313348936604029 3331 2849257 YMR203W TOM40
SGTC_1076 itraconazole 331 nM -0.489822011111378 0.314301812937537 no 2324 0.312129926833898 3333 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1788 fluconazole 20 µM -0.491414881025712 0.31376146818016 no 2325 0.311566520666302 3345 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2343 7990716 14.84 µM -0.491534169388463 0.313721018380765 no 2326 0.311524345497108 3238 6456862
SGTC_3197 9113331 49.47 µM -0.493472939456198 0.31306391004816 no 2327 0.310839227872754 3436 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2733 amorolfine 100 µM -0.494567109107427 0.312693324317951 no 2328 0.31045286207546 3329 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1923 st058458 19.1 µM -0.494855435396796 0.312595702207618 no 2329 0.31035108502606 3438 3534982
SGTC_689 0833-0039 98 µM -0.495710994389188 0.312306102683422 no 2330 0.31004916451936 3326 5374726
SGTC_1727 st034309 9.9045 µM -0.498721361692361 0.311288041042067 no 2331 0.30898784674683 3443 870305
SGTC_1963 st076565 50.3 µM -0.499653211797269 0.310973194978883 no 2332 0.308659641411089 3268 4914280
SGTC_244 nsc-207895 1.295 µM -0.501008881844618 0.31051539902913 no 2333 0.308182436041635 3257 42640
SGTC_1423 4048-0112 5.59 µM -0.50111898124646 0.310478232453076 no 2334 0.308143694496361 3365 X1423
SGTC_1401 3807-4679 7.6 µM -0.501191783184316 0.31045365755331 no 2335 0.308118078277969 3342 3291456
SGTC_831 k061-1017 217 µM -0.503123951048479 0.309801747690973 no 2336 0.307438564176612 3347 1240153
SGTC_2565 isoliquiritigenin 100 µM -0.503959678871991 0.309519959717694 no 2337 0.30714485583034 3356 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2156 5649887 115 µM -0.504066411553077 0.309483979999617 no 2338 0.307107354579339 3389 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1864 st057645 30.4 µM -0.506201559484898 0.308764603029827 no 2339 0.306357580175936 3405 688666
SGTC_618 k072-0232 33.2 µM -0.50639623285891 0.30869904983938 no 2340 0.306289259302862 3346 5872756 YGL099W LSG1
SGTC_987 1497-1013 404 µM -0.506964276404024 0.308507804976314 no 2341 0.306089942188419 3381 1676435
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.507043229110459 0.308481227850618 no 2342 0.306062243527093 3370 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_96 0929-0093 37.281 µM -0.508743065073452 0.307909271224964 no 2343 0.305466166030736 3294 6991579
SGTC_3176 9106582 49.47 µM -0.509187401702984 0.307759838757052 no 2344 0.305310436440682 3314 17018027
SGTC_1321 1326-2144 215 µM -0.509496144856749 0.307656025774888 no 2345 0.305202249933453 3360 3513030
SGTC_756 0508-1999 28.3 µM -0.509782560939515 0.30755973390173 no 2346 0.305101902257288 3280 6753853
SGTC_1117 retinoic acid 1.10837 µM -0.510882789021118 0.307189965213691 no 2347 0.304716566714617 3431 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_686 1319-0111 510 µM -0.513247440172971 0.30639590809109 no 2348 0.303889122459426 3441 4562600
SGTC_83 0170-0301 39.027 µM -0.513948841656237 0.306160549814817 no 2349 0.303643879257537 3356 3089716
SGTC_1837 st055472 66.5 µM -0.514104942940872 0.306108180236944 no 2350 0.303589310871753 3465 676091
SGTC_2331 7980721 200 µM -0.519012266693816 0.304463873329437 no 2351 0.301876093566683 3315 2981221
SGTC_1320 1313-0481 95.3 µM -0.519812401135598 0.304196143782762 no 2352 0.301597167535132 3454 6813365 YLR208W SEC13
SGTC_2711 st079103 59.1 µM -0.519890369659511 0.304170060678835 no 2353 0.301569993988743 3328 54693780
SGTC_3216 9129716 49.47 µM -0.52000632517166 0.304131271487668 no 2354 0.301529583275626 3304 8056934
SGTC_1177 0983-0204 23.6 µM -0.520386540318203 0.304004098191848 no 2355 0.301397094680699 3423 766818
SGTC_413 propylparaben 100 µM -0.521150910937533 0.303748505416734 no 2356 0.301130823786014 3314 7175 A pharmaceutical preservative.
SGTC_818 4072-2707 53.5 µM -0.521686104477244 0.303569602727511 no 2357 0.300944450557896 3309 882871
SGTC_444 curcumin 90.4 µM -0.521722854280602 0.303557319853862 no 2358 0.300931654891386 3403 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2740 felodipine 17.08 µM -0.526240139750194 0.302049202869745 no 2359 0.299360684049312 3358 3333 L-type calcium channel blocker
SGTC_1683 st010134 710 nM -0.526923509589305 0.30182134993727 no 2360 0.299123353605239 3319 3818134
SGTC_2816 7982706 58.44 µM -0.528938164067546 0.301150062796868 no 2361 0.298424173167817 3371 2981853
SGTC_859 0439-0102 54.6 µM -0.528984654585616 0.301134580001278 no 2362 0.298408047540589 3446 610143
SGTC_339 3091-4833 71.4 µM -0.529534539958544 0.300951478202172 no 2363 0.298217345265884 3400 3240077
SGTC_989 1501-0895 10.3 µM -0.530142068366851 0.300749240713109 no 2364 0.298006716732175 3445 2830112
SGTC_3146 9095609 49.47 µM -0.530379313370343 0.300670281908644 no 2365 0.297924482913065 3355 17173999
SGTC_1281 0884-0031 11.8 µM -0.53067594412009 0.300571571774952 no 2366 0.297821679373891 3371 1548255
SGTC_1224 0823-0416 294 µM -0.530920606024671 0.30049016638304 no 2367 0.297736898893114 3436 3598164
SGTC_804 1595-0054 20.9 µM -0.532032472416457 0.300120344978771 no 2368 0.297351752659291 3314 761523 Stimulates phospholipase C.
SGTC_297 0986-0032 24 µM -0.532294258236363 0.300033301515657 no 2369 0.297261104173857 3330 2847425
SGTC_1952 st077036 64.1 µM -0.532726211883568 0.299889702435439 no 2370 0.297111559350399 3412 2937007
SGTC_3105 9121040 49.47 µM -0.533918365178709 0.299493543373162 no 2371 0.296699007648704 3341 41448907
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.534573358794178 0.299275986435595 no 2372 0.296472454941281 3462 1273210
SGTC_2706 st078239 82.5 µM -0.535616571263263 0.298929630242311 no 2373 0.296111786797059 3441 15434492
SGTC_2722 naftopidil 47.16 µM -0.535767437288678 0.298879556399259 no 2374 0.296059644800582 3402 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1088 bifonazole 369 nM -0.536695209362405 0.298571703994015 no 2375 0.295739082860782 3389 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1434 4073-0095 163 µM -0.539091513956873 0.297777232717845 no 2376 0.29491185536739 3442 24133745
SGTC_2511 berberine 10.47 µM -0.540409012828976 0.297340840126655 no 2377 0.294457496807215 3368 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1451 4152-0210 104 µM -0.54169996169694 0.296913525267644 no 2378 0.294012608070024 3456 659563
SGTC_1785 bathophenanthroline 24 µM -0.542152141631198 0.29676391640829 no 2379 0.293856850661501 3320 72812 An iron chelator.
SGTC_962 1254-0300 21.5 µM -0.543504205929307 0.296316776613381 no 2380 0.293391347907375 3377 7340576
SGTC_1682 st012968 530 nM -0.543510909901843 0.296314560319372 no 2381 0.293389040645466 3306 24207270
SGTC_1715 st032160 10.2275 µM -0.543602378434395 0.296284322118259 no 2382 0.293357561365188 3405 5289825
SGTC_1934 st074720 32.6 µM -0.546499640202344 0.295327261631341 no 2383 0.292361267487945 3398 17250992
SGTC_2144 5628481 200 µM -0.547444590658717 0.29501542147628 no 2384 0.292036663905278 3377 2818399
SGTC_2735 sertaconazole 140 nM -0.54766418197448 0.294942976557064 no 2385 0.291961255275214 3439 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_665 3914-0008 307 µM -0.548694980198079 0.294603017642962 no 2386 0.291607395837838 3366 1069549
SGTC_1710 st031758 61.5 µM -0.548754569893418 0.294583370394019 no 2387 0.291586945596385 3484 5394341
SGTC_1569 carminic acid 40.6 µM -0.551145950701769 0.293795410449509 no 2388 0.290766813944576 3465 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2949 9072542 2.23 µM -0.551948142203557 0.293531306951617 no 2389 0.29049194161451 3432 16457352
SGTC_109 0132-0036 33.701 µM -0.552417824785541 0.293376725581071 no 2390 0.290331060520462 3369 67274 A color developer.
SGTC_2200 6600604 21.907 µM -0.555508258099558 0.292360547756343 no 2391 0.28927353160216 3389 2904777
SGTC_1604 st002052 72.4 µM -0.55999078072972 0.290889547116504 no 2392 0.287742863050446 3506 6254834 YHR062C RPP1
SGTC_441 propafenone 146 µM -0.560835557013336 0.290612710184559 no 2393 0.287454822340058 3408 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2433 5607874 27.82 µM -0.560932617594028 0.29058091089815 no 2394 0.287421736635136 3429 2252428
SGTC_1054 3429-0080 167 µM -0.561028710319899 0.290549430307169 no 2395 0.287388982623947 3494 1162877
SGTC_630 4356-0227 183 µM -0.563267413798076 0.289816468849914 no 2396 0.286626401972701 3459 779312
SGTC_3330 9141424 71.43 µM -0.563314061499624 0.289801205415141 no 2397 0.28661052234684 3458 27261020
SGTC_2107 5363541 170.161 µM -0.567240749564501 0.288517721398428 no 2398 0.285275312996852 3455 244052
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.568079201860074 0.288244010867084 no 2399 0.284990594714052 3421 4330530
SGTC_1743 st037606 46.3785 µM -0.568865379707203 0.287987476501666 no 2400 0.284723750742303 3426 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1684 st024538 14.6195 µM -0.569369950317962 0.287822889006668 no 2401 0.284552552569089 3400 6732859
SGTC_1831 st055328 12 µM -0.571336419375077 0.287181864569567 no 2402 0.283885809453891 3486 1103068
SGTC_1881 5652484 16 µM -0.571929113309445 0.286988792376546 no 2403 0.283684999776265 3471 2255129
SGTC_3269 9137823 49.47 µM -0.573807884301104 0.286377182628277 no 2404 0.283048906429803 3364 17682936
SGTC_1188 1403-0014 4.57 µM -0.573809419332904 0.286376683171454 no 2405 0.283048386995854 3437 9614867
SGTC_645 0845-0943 5.41 µM -0.574186361512475 0.286254049147021 no 2406 0.282920848725453 3432 1885106
SGTC_1510 1123-0200 71.5 µM -0.574592524990984 0.286121936210238 no 2407 0.282783454331105 3576 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2789 5281112 71.43 µM -0.574825656866356 0.286046118410603 no 2408 0.28270460644706 3418 765948
SGTC_577 r071-0003 38.6 µM -0.575430443447462 0.285849477737377 no 2409 0.28250010992734 3464 4568517 YMR134W ERG29
SGTC_724 3910-0327 137 µM -0.576715333833776 0.285431921181311 no 2410 0.282065886102962 3480 2885483
SGTC_1729 st035615 45.989 µM -0.5778330752331 0.285068920165678 no 2411 0.281688411232211 3424 17385451
SGTC_2218 6965428 192.983 µM -0.577837628224864 0.28506744197275 no 2412 0.281686874129685 3480 675684
SGTC_949 1165-0505 146 µM -0.577950587930819 0.28503076918266 no 2413 0.281648739917492 3440 6244267
SGTC_1529 apigenin 74 µM -0.578465618543391 0.284863591088489 no 2414 0.281474901628252 3560 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2923 7992654 58.14 µM -0.578486293766581 0.284856880921633 no 2415 0.281467924200815 3448 2985126
SGTC_678 1218-2179 85.9 µM -0.579453072657504 0.284543195986555 no 2416 0.281141751072617 3471 6820081 YOR116C RPO31
SGTC_42 0133-0086 60.653 µM -0.579653268754391 0.284478260186466 no 2417 0.28107423147455 3438 162923 Model of phenazepam hydroxylation.
SGTC_795 0685-0265 78 µM -0.58008928786142 0.284336857109713 no 2418 0.280927203602044 3552 302754
SGTC_716 1683-5115 658 µM -0.58015874801146 0.284314333953878 no 2419 0.28090378471733 3528 723597
SGTC_1051 3253-3903 78 µM -0.58085608889238 0.284088261390929 no 2420 0.280668724580718 3417 5509239
SGTC_1699 st031318 29.054 µM -0.582672171772137 0.283499905139454 no 2421 0.280057005094878 3492 5340658
SGTC_128 0906-2981 13.371 µM -0.585321753345475 0.282642569330225 no 2422 0.27916569530262 3486 6740226
SGTC_363 0455-0021 3.06 µM -0.585531500821097 0.282574753754077 no 2423 0.279095195944306 3504 4597466
SGTC_296 1222-0039 74.9 µM -0.586939166049696 0.282119829799304 no 2424 0.278622282100173 3450 5984176
SGTC_1127 asiatic acid 681.4 nM -0.587837321575902 0.281829751657442 no 2425 0.278320745254863 3434 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_486 niguldipine 82 µM -0.588780509918789 0.281525284033795 no 2426 0.27800426092096 3475 1236 A calcium channel blocker.
SGTC_1738 st035555 74 µM -0.589958508325592 0.28114524110377 no 2427 0.277609233480634 3499 5331140
SGTC_931 2812-0076 566 µM -0.591768979588156 0.280561634863588 no 2428 0.277002649096068 3469 3450959
SGTC_701 4424-0219 185 µM -0.592750268706345 0.280245561041219 no 2429 0.276674147123223 3551 2911779
SGTC_1294 1000-1494 117 µM -0.594753761368634 0.279600770945984 no 2430 0.276004039789963 3461 712797 YDL207W GLE1
SGTC_1488 4013-0813 75.9 µM -0.595566643693728 0.279339364098343 no 2431 0.275732382862753 3467 2910057
SGTC_253 dyclonine 31.25 µM -0.597639395390945 0.278673346124975 no 2432 0.275040285878913 3545 3180 An oral anasthetic.
SGTC_1571 st070080 73.4 µM -0.598407133399819 0.278426852404742 no 2433 0.274784153586226 3562 4315245
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.598829274099566 0.278291363130813 no 2434 0.274643369381471 3563 23847180
SGTC_2105 5350118 200 µM -0.600940931172001 0.277614093638105 no 2435 0.273939664869795 3506 2133313
SGTC_2097 5376186 200 µM -0.60235443035447 0.27716119394383 no 2436 0.273469118246802 3508 742755
SGTC_2762 leflunomide 42.06 µM -0.602803121982626 0.277017504152574 no 2437 0.273319834815052 3513 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_181 1447-1644 8.07 µM -0.603290537629034 0.27686145464615 no 2438 0.273157713329746 3498 534600
SGTC_2286 7945697 125 µM -0.60418565895483 0.276574987509019 no 2439 0.272860107209363 3484 1245733
SGTC_1008 4106-0037 6 µM -0.60799595054815 0.275357201780881 no 2440 0.271595079821827 3516 2905394
SGTC_344 k064-0035 6.43 µM -0.608143273861964 0.275310169645243 no 2441 0.27154622677611 3451 5088750
SGTC_1286 0929-0070 131 µM -0.6104383765685 0.274577982064355 no 2442 0.270785726444497 3576 1420408
SGTC_3029 9088683 49.47 µM -0.611933336654089 0.27410157453929 no 2443 0.270290932144982 3540 25236615
SGTC_1392 3455-1037 33.9 µM -0.61377511752993 0.273515205681037 no 2444 0.269681970992569 3577 981132
SGTC_399 oxolinic acid 75 µM -0.614417952865341 0.273310692087142 no 2445 0.26946958766683 3483 4628 A DNA gyrase inhibitor.
SGTC_1706 st031321 9.9705 µM -0.61470230225791 0.273220252471004 no 2446 0.269375669566721 3544 6103185
SGTC_2592 piperlongumine 83.33 µM -0.614909500870262 0.273154360621716 no 2447 0.269307244027826 3485 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_909 3448-9333 149 µM -0.615779873035281 0.272877657013879 no 2448 0.269019906436362 3508 3344074
SGTC_2252 omeprazole 400 µM -0.61590058554027 0.272839291783096 no 2449 0.268980067545241 3487 4594 A proton pump inhibitor.
SGTC_845 0330-0138 4.51 µM -0.616785221798599 0.272558215560382 no 2450 0.268688200401335 3522 9039800
SGTC_2755 lomerizine 42.69 µM -0.61687903851261 0.272528415530072 no 2451 0.268657256882919 3535 3949 A calcium channel blocker.
SGTC_147 4466-0538 29.23 µM -0.618474515425063 0.272021874547147 no 2452 0.268131295877402 3634 6742687 YHR072W ERG7
SGTC_2256 7954252 200 µM -0.621124042051139 0.271181723590631 no 2453 0.267259005835859 3503 2972920
SGTC_2561 acetosyringone 100 µM -0.621260128166008 0.271138606356394 no 2454 0.267214241598565 3498 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2526 patulin 37.61 µM -0.621482319867791 0.271068214959882 no 2455 0.267141161878768 3583 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_847 0342-0274 5.54 µM -0.622231496602768 0.270830939375951 no 2456 0.266894829104624 3548 18097
SGTC_2537 larixol 68.93 µM -0.623024010345705 0.270580051193985 no 2457 0.266634371881274 3566 6708759
SGTC_3301 9125354 19.7965 µM -0.623540980864085 0.270416455051913 no 2458 0.266464540380467 3540 41905162
SGTC_2829 7992743 58.44 µM -0.623807026751566 0.270332283678077 no 2459 0.2663771621968 3505 16462845
SGTC_481 bay k-8644 50 µM -0.624178936889722 0.270214641017473 no 2460 0.266255039029488 3493 2303 A calcium channel antagonist.
SGTC_1233 0325-0408 14.2 µM -0.624214545737892 0.27020337856538 no 2461 0.266243347731167 3556 12874
SGTC_3182 9108849 49.47 µM -0.625055424386595 0.269937491689908 no 2462 0.26596734124334 3579 17133045
SGTC_1607 st000305 50.6 µM -0.625297790965905 0.269860879394947 no 2463 0.265887814771889 3556 5457690
SGTC_2202 7226349 200 µM -0.625614013365657 0.269760937577655 no 2464 0.265784072498373 3511 844334
SGTC_3025 9087895 49.47 µM -0.625855702360801 0.269684564477891 no 2465 0.265704796044112 3563 17173641
SGTC_3240 9133527 49.47 µM -0.625919574803728 0.269664382759988 no 2466 0.265683847234719 3542 17617455
SGTC_175 3793-3120 23.7 µM -0.626567914592332 0.269459570249038 no 2467 0.265471252910977 3520 5322297
SGTC_1475 4092-1048 11.7 µM -0.627628845968778 0.269124587078493 no 2468 0.265123553721677 3560 2881759
SGTC_1656 st012921 11 µM -0.627767457813936 0.26908083659918 no 2469 0.265078143531761 3509 6732821
SGTC_214 4373-3496 70 µM -0.628023735577957 0.268999956268207 no 2470 0.264994195587384 3633 3779166
SGTC_2539 epi(13)torulosol 80 µM -0.628759695266697 0.268767757925699 no 2471 0.264753195155478 3531 6708597
SGTC_2371 9071574 200 µM -0.629865225174082 0.268419147955222 no 2472 0.264391383277396 3545 45596039
SGTC_548 1436-0017 110 µM -0.63097915157207 0.268068120414747 no 2473 0.26402707817275 3620 9677137
SGTC_1804 st050076 49.1 µM -0.631489494685756 0.267907375084479 no 2474 0.263860258012678 3587 3895976
SGTC_861 0443-0273 110 µM -0.63240412924987 0.267619409564677 no 2475 0.263561418207465 3558 6149169
SGTC_1004 4084-0029 199 µM -0.633853650193058 0.267163359060704 no 2476 0.263088168242688 3579 716894 YLR208W SEC13
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.634732279026023 0.266887114597653 no 2477 0.262801518743269 3584 7104
SGTC_1853 st056710 91.2 µM -0.636602290086222 0.26629965633647 no 2478 0.262191966563513 3639 269167
SGTC_1266 0828-0227 32.9 µM -0.637921853771876 0.26588551362834 no 2479 0.261762275553373 3519 3913820
SGTC_3232 9132874 49.47 µM -0.638664097186158 0.265652705363502 no 2480 0.261520736847532 3542 3784940
SGTC_1412 3909-8563 178 µM -0.640112431979315 0.265198725931687 no 2481 0.261049753614066 3641 23767530
SGTC_421 streptovitacin 30 mM -0.640676765405889 0.265021942766557 no 2482 0.260866356449992 3600 91467 include heat shock
SGTC_2838 9002687 71.43 µM -0.641089637876065 0.264892644216441 no 2483 0.260732223083156 3560 6457060
SGTC_942 3253-1115 227 µM -0.641134268539813 0.264878669229921 no 2484 0.260717725668278 3615 46497897
SGTC_798 1287-0182 476 µM -0.641810836428357 0.264666864668121 no 2485 0.260498006387971 3622 1649755
SGTC_1513 0337-0559 19 µM -0.645806930821253 0.263417617247815 no 2486 0.25920219944866 3494 775073
SGTC_602 3130-1533 38.1 µM -0.646098919577793 0.263326454723202 no 2487 0.259107647522149 3606 720941
SGTC_1568 digitonin 820 nM -0.647520364804009 0.26288289205767 no 2488 0.258647609354507 3608 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1492 4158-0558 28.5 µM -0.647784959698496 0.262800367289666 no 2489 0.258562022266055 3579 3967268
SGTC_1466 k213-0079 57.5 µM -0.647987162234522 0.26273731106984 no 2490 0.258496626786215 3573 3657981
SGTC_2543 pimpinellin 60.67 µM -0.648476139138342 0.262584857166723 no 2491 0.258338519381074 3529 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1151 3909-8316 15.3 µM -0.648737247215143 0.262503467071089 no 2492 0.258254112362812 3609 800431
SGTC_1370 2001-0092 44.6 µM -0.649273320287303 0.262336408016716 no 2493 0.258080863684175 3672 790957
SGTC_722 3534-0461 190 µM -0.649548324357721 0.262250728298963 no 2494 0.257992010965201 3569 658262
SGTC_2081 5214970 32.255 µM -0.650352931195443 0.262000128956425 no 2495 0.25773213686085 3571 2063512
SGTC_3207 9114163 49.47 µM -0.65110911364861 0.261764723615572 no 2496 0.257488026918182 3649 849233
SGTC_1707 st032323 6.317 µM -0.652367391551597 0.2613732527868 no 2497 0.257082097468464 3543 3132057 YMR211W DML1
SGTC_1497 4476-2978 41.3 µM -0.652533959518171 0.261321453315012 no 2498 0.257028386407467 3618 1528379
SGTC_2650 prasterone 100 µM -0.652620153921598 0.261294650564371 no 2499 0.257000594682613 3560 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2953 9074162 66.49 µM -0.654175281880303 0.260811315398748 no 2500 0.256499442290878 3563 16451992
SGTC_2309 7664088 163.95 µM -0.654441675593683 0.260728566161118 no 2501 0.256413645893895 3613 704922
SGTC_2493 resveratrol 26.09 µM -0.654936812439063 0.260574798894654 no 2502 0.256254218814132 3550 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_212 3807-4682 38.772 µM -0.655725809131658 0.260329868464058 no 2503 0.256000279830182 3684 3125501 YBL034C STU1
SGTC_549 1661-1316 519 µM -0.656121574704067 0.260207054544389 no 2504 0.255872951940816 3637 2857282
SGTC_684 1140-0066 328 µM -0.656342665108939 0.260138458801592 no 2505 0.25580183590447 3615 6813534
SGTC_3277 9138724 49.47 µM -0.656350106298543 0.260136150252392 no 2506 0.255799442547652 3527 15943418
SGTC_2701 st077767 14.721 µM -0.65727088529179 0.259850569978798 no 2507 0.25550337682177 3604 5721188
SGTC_1794 st048918 76.9 µM -0.658086856946553 0.259597631021505 no 2508 0.255241160368593 3554 672303
SGTC_2184 6075246 200 µM -0.658414455824716 0.259496116064005 no 2509 0.255135924475785 3611 2267320
SGTC_2043 5101342 149 µM -0.663250048461072 0.258000071286929 no 2510 0.253585211237558 3595 678451
SGTC_3064 1327-0027 10 µM -0.664733436021066 0.257542036382258 no 2511 0.25311050197312 3516 16000455 YPR107C YTH1
SGTC_225 nsc-122657 1.016 µM -0.665964322321493 0.257162288757683 no 2512 0.252716952563503 3573 275685
SGTC_1380 2291-0730 164 µM -0.666105550171499 0.257118736389312 no 2513 0.252671818613193 3603 2999191
SGTC_624 k048-0052 28 µM -0.668086148318273 0.256508356511829 no 2514 0.252039301603876 3581 6835531
SGTC_1404 3909-7820 48.3 µM -0.668743936809349 0.25630580664504 no 2515 0.251829417485789 3604 23741373
SGTC_2713 st079149 53.4 µM -0.670249226195831 0.255842603495619 no 2516 0.251349464083582 3644 3103253
SGTC_216 k038-0035 28.382 µM -0.671328001967895 0.255510914802361 no 2517 0.251005799927332 3572 4444231 YPR107C YTH1
SGTC_2013 4024628 200 µM -0.672354096660214 0.255195632432987 no 2518 0.250679149176739 3646 5230760
SGTC_2055 5235184 200 µM -0.674473859154524 0.254544949674813 no 2519 0.250005049827785 3638 2836034
SGTC_2352 9027995 87.8 µM -0.674943383800641 0.254400941955656 no 2520 0.24985586792409 3601 2997347
SGTC_652 0437-0092 114 µM -0.675631050023009 0.254190105208706 no 2521 0.249637461289467 3621 3091274
SGTC_2583 asiatic acid 100 µM -0.676907778502371 0.253798906566414 no 2522 0.249232234258962 3661 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2754 granisetron 64.02 µM -0.678014118799213 0.253460171858784 no 2523 0.248881370643512 3641 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1904 st060225 78 µM -0.678450045611335 0.253326766863037 no 2524 0.248743193508238 3633 66595
SGTC_2638 epoxomicin 18 µM -0.678707587245824 0.253247969741933 no 2525 0.24866157890113 3636 9915668 A protesome inhibitor.
SGTC_993 3909-8757 62.7 µM -0.678902925460669 0.25318821289795 no 2526 0.248599685988925 3609 4288324 YLR208W SEC13
SGTC_1032 k061-1018 98.7 µM -0.679078773143201 0.253134424838681 no 2527 0.248543975671627 3721 4005393
SGTC_2835 9006588 71.43 µM -0.679690574180917 0.252947334778552 no 2528 0.248350202778587 3646 2345538
SGTC_714 4296-0578 26.1 µM -0.682442250838917 0.252106766698819 no 2529 0.24747967360938 3649 1589775
SGTC_2745 rifampicin 24.3 µM -0.683064332261634 0.251916940873032 no 2530 0.247283096175646 3570 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_191 3914-0123 66.505 µM -0.683207439125855 0.251873283022784 no 2531 0.247237886288704 3582 3144412
SGTC_3245 9134821 49.47 µM -0.684591326434403 0.251451304341289 no 2532 0.246800920917508 3627 17014901
SGTC_2836 9010338 19.48 µM -0.685927843564533 0.251044124833945 no 2533 0.246379305556938 3573 2994051
SGTC_381 3461-2219 42.7 µM -0.6860578747066 0.251004528545646 no 2534 0.246338306775667 3636 2883159
SGTC_3103 9120822 49.47 µM -0.686389208205495 0.250903647835292 no 2535 0.24623385395343 3717 17141819
SGTC_2106 5357045 167.29 µM -0.686854707937826 0.250761953956122 no 2536 0.246087145379749 3670 668842
SGTC_17 0960-0276 49.807 µM -0.687641639919461 0.250522515419014 no 2537 0.245839239726291 3660 6821114
SGTC_2744 captopril 92.04 µM -0.688649803867141 0.250215940085882 no 2538 0.245521835774306 3631 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1260 0700-1617 7.75 µM -0.689720223095653 0.249890651268053 no 2539 0.24518507288054 3663 2853078
SGTC_232 clozapine 119 µM -0.690062913287153 0.249786558881945 no 2540 0.245077312174556 3626 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2123 5259487 200 µM -0.690077396478345 0.249782160109564 no 2541 0.2450727584212 3632 2173474
SGTC_746 1095-0025 46.6 µM -0.69189641339506 0.249230023260503 no 2542 0.244501191586879 3673 6749286
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.692883634187077 0.248930638281598 no 2543 0.244191290495139 3621 641818 YHR062C RPP1
SGTC_874 0599-0792 117 µM -0.693239195885913 0.248822857397093 no 2544 0.244079727078219 3689 765305
SGTC_802 4112-3352 742 µM -0.694033714779968 0.248582105887184 no 2545 0.243830532892758 3723 704594
SGTC_563 tetrahydrosecaminediol 614 µM -0.694549653736606 0.2484258348873 no 2546 0.243668786529884 3701 334274 A psychoactive constituent of the cannabis plant.
SGTC_1968 st069590 43.6 µM -0.694665461628542 0.248390765424309 no 2547 0.243632488830872 3613 6384066
SGTC_2932 9016711 44.54 µM -0.697026243262312 0.247676438525256 no 2548 0.242893185228102 3646 7117328
SGTC_2653 dihydrofissinolide 100 µM -0.697900744899143 0.247412109972069 no 2549 0.24261963426156 3710 6857746
SGTC_2782 7736369 71.43 µM -0.700077501015952 0.246754814712532 no 2550 0.241939452882448 3731 2950836 YOL077C BRX1
SGTC_2254 7938975 95.19 µM -0.700591216612997 0.246599829157667 no 2551 0.24177908071619 3715 2969277
SGTC_3015 9080845 49.47 µM -0.702883174662735 0.245908992043026 no 2552 0.241064278713815 3725 5296973
SGTC_2854 9024559 71.43 µM -0.703181504501531 0.245819146554253 no 2553 0.240971321999653 3663 3163529
SGTC_660 4031-1742 102 µM -0.704668111539317 0.245371700410115 no 2554 0.240508400265498 3609 6738706
SGTC_2054 5233173 129 µM -0.704669920918852 0.245371156081185 no 2555 0.240507837129295 3697 6889
SGTC_60 0986-0278 202 µM -0.706133187706763 0.24493116335155 no 2556 0.240052657337959 3518 3110598
SGTC_3040 9091894 49.47 µM -0.70646784985707 0.244830592779921 no 2557 0.239948619696638 3604 25236966
SGTC_1726 st035556 14.5795 µM -0.706699858567461 0.244760884024391 no 2558 0.239876508739085 3774 5919439
SGTC_2598 perillyl alcohol 100 µM -0.707236500181209 0.244599686978192 no 2559 0.239709759696488 3693 10819 An apoptosis inducer.
SGTC_22 0964-0034 14.468 µM -0.707550365644803 0.244505434203435 no 2560 0.239612262544764 3667 138402
SGTC_939 1165-0479 45.3 µM -0.707705800156933 0.244458764971459 no 2561 0.239563987381345 3630 1377347
SGTC_2312 7706453 155.7 µM -0.707822008153128 0.244423876641538 no 2562 0.239527898737149 3729 976098
SGTC_1920 st075728 45.7 µM -0.707937107553527 0.244389323782575 no 2563 0.239492157295766 3690 3400306
SGTC_2187 6125751 200 µM -0.70800671118504 0.244368430038173 no 2564 0.239470544920116 3682 874498
SGTC_90 0870-0863 4.608 µM -0.711079345052673 0.243447041196294 no 2565 0.238517534319327 3686 1738164
SGTC_1805 st050013 60.3 µM -0.7111546083039 0.243424495625643 no 2566 0.238494216688236 3661 4037144
SGTC_3096 9117468 49.47 µM -0.711604937315457 0.243289620367092 no 2567 0.238354724399138 3625 41316311
SGTC_1521 st012942 49.4 µM -0.711847566499351 0.243216968747134 no 2568 0.238279586985245 3738 24207259
SGTC_791 1348-1292 225 µM -0.712151553982168 0.243125960872563 no 2569 0.238185466445017 3698 5437054
SGTC_2023 5144124 124 µM -0.712603008877938 0.242990838141207 no 2570 0.238045724672658 3699 2830192
SGTC_2221 6807166 181.081 µM -0.712899242915598 0.242902195874861 no 2571 0.237954053845886 3643 674925
SGTC_1414 3917-0015 5.4 µM -0.713863724415574 0.242613714821788 no 2572 0.237655725256387 3676 6618702
SGTC_1705 st027868 56.3335 µM -0.714966493441762 0.242284098759623 no 2573 0.237314873871687 3711 292948
SGTC_1892 st058411 7.36 µM -0.716618487591066 0.241790774556295 no 2574 0.236804766937256 3665 3934738
SGTC_2693 st077581 40.7 µM -0.71752625942515 0.241519924835653 no 2575 0.236524719748941 3741 25238761
SGTC_2310 7668677 200 µM -0.718360611140684 0.241271126690692 no 2576 0.236267483453668 3707 2197143
SGTC_103 0844-0104 51.839 µM -0.71854512923544 0.241216123432186 no 2577 0.236210616082441 3727 5375804
SGTC_368 fentichlor 4.58 µM -0.718583901107747 0.241204566736757 no 2578 0.236198667782204 3697 7329 A pesticide.
SGTC_24 0417-1663 219 µM -0.71963353794002 0.240891816858847 no 2579 0.235875328468491 3673 4329390
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.721088006077484 0.240458808283932 no 2580 0.235427684960307 3719 688669
SGTC_3070 9117005 49.47 µM -0.721605412990006 0.240304873756641 no 2581 0.235268555107451 3742 8779016
SGTC_439 amiodarone 34.4 µM -0.722013991284705 0.240183354947859 no 2582 0.23514293775509 3636 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1874 staurosporine 7.6 µM -0.722469958318258 0.240047781396621 no 2583 0.235002794487451 3737 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2050 5263056 171 µM -0.722581263754387 0.240014693074798 no 2584 0.234968591330905 3729 763468 YGL055W OLE1
SGTC_2226 7298446 200 µM -0.723053168140225 0.239874435332627 no 2585 0.234823609926137 3699 3283010
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.723206745218671 0.239828799344121 no 2586 0.234776437686329 3695 77254
SGTC_277 nystatin 15.5 µM -0.723822920927882 0.239645748119232 no 2587 0.234587227826693 3714 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_761 k216-0224 480 µM -0.725509188798705 0.239145187955112 no 2588 0.234069854885653 3747 1340404
SGTC_969 1313-0238 134 µM -0.726000865315081 0.238999343913833 no 2589 0.233919120041299 3736 5212874
SGTC_2189 6047310 154.431 µM -0.72702261374206 0.238696422346439 no 2590 0.233606051428941 3665 711535
SGTC_1182 1222-0449 220 µM -0.727680648598424 0.238501443569068 no 2591 0.233404549457788 3700 658318
SGTC_3076 9116187 49.47 µM -0.727890319194609 0.238439335521739 no 2592 0.233340364856908 3696 27241210
SGTC_3117 9124945 49.47 µM -0.729115805036974 0.238076502679007 no 2593 0.23296541371395 3646 17592065
SGTC_331 k048-0133 24.5 µM -0.730616682531021 0.237632546446878 no 2594 0.232506659645399 3694 6813582
SGTC_1546 5-methoxyflavanone 78.7 µM -0.731212195006968 0.237456521135627 no 2595 0.232324776242119 3745 147795
SGTC_1527 coumarin 137 µM -0.732496636388954 0.237077101704859 no 2596 0.231932747494601 3776 323 A hepatotoxic, DNA x-linker.
SGTC_3340 9146634 11.102 µM -0.732647567035087 0.237032539210549 no 2597 0.231886705635719 3745 4907387
SGTC_946 3434-1334 87.4 µM -0.734045996383724 0.236619869892655 no 2598 0.23146035262363 3718 4047976
SGTC_3203 9113543 49.47 µM -0.734267202951253 0.236554629197064 no 2599 0.231392951245206 3786 17018012
SGTC_1516 st013856 110 µM -0.736935419583476 0.235768469403427 no 2600 0.230580811612917 3747 5281404 A mutagen and neurotoxin.
SGTC_2597 laccaic acid a 100 µM -0.73872729078077 0.235241324506732 no 2601 0.230036305283848 3739 5491415 A textile dye.
SGTC_1778 st046819 58.9 µM -0.740628884887421 0.234682613074213 no 2602 0.229459244630961 3786 671715
SGTC_1739 st037196 92.5 µM -0.742314856819143 0.234187868346051 no 2603 0.228948296215746 3734 612214
SGTC_2852 9023854 51.95 µM -0.74249893800316 0.234133885119389 no 2604 0.228892547501719 3821 19798528
SGTC_1015 4130-4525 82 µM -0.744992108350142 0.233403422742853 no 2605 0.228138245318855 3756 1363237
SGTC_2926 9010726 65.15 µM -0.745708446390152 0.233193780252648 no 2606 0.22792177788443 3765 2994293
SGTC_766 1391-0721 126 µM -0.747788668287699 0.232585578307717 no 2607 0.227293819101769 3732 1020919 YIL115C NUP159
SGTC_1756 st041558 35.5 µM -0.748357959934014 0.232419286294846 no 2608 0.227122136491773 3806 3955792
SGTC_2721 ifenprodil 61.44 µM -0.749085302876726 0.232206923213106 no 2609 0.226902896385289 3736 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2195 6536160 144.242 µM -0.750138128997281 0.231899719831681 no 2610 0.226585758719974 3678 3834386
SGTC_1702 st027038 51 µM -0.750180874439525 0.231887251953017 no 2611 0.226572888007192 3761 5521182
SGTC_1092 toremifene 6.32 µM -0.750307542163718 0.231850308035336 no 2612 0.226534750600884 3737 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1245 0418-0076 17.2 µM -0.750352221279965 0.231837277703219 no 2613 0.226521299375675 3778 6790114
SGTC_1239 0337-0584 35.4 µM -0.751827133930536 0.231407359462635 no 2614 0.226077511086535 3808 914301 YML130C ERO1
SGTC_757 1066-0008 322 µM -0.752668685739707 0.231162257171836 no 2615 0.225824515871805 3808 6842497
SGTC_219 mitoxanthrone 164.414 µM -0.754701379621898 0.230570832223967 no 2616 0.225214089272387 3750 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2161 5662504 8.5105 µM -0.755415405326901 0.230363282857557 no 2617 0.224999886343241 3756 2859334
SGTC_2986 9022445 71.43 µM -0.755496505020727 0.230339715818255 no 2618 0.224975564282147 3681 6459286
SGTC_2301 7769476 200 µM -0.757726131016477 0.229692329382545 no 2619 0.224307476102397 3816 977820
SGTC_739 1486-1183 203 µM -0.758309070284045 0.229523237373142 no 2620 0.224132989296482 3729 4346692
SGTC_779 1360-0071 233 µM -0.7583675149876 0.229506288284551 no 2621 0.224115499737863 3834 7566
SGTC_2435 5706476 10.6 µM -0.758380771762956 0.229502443889028 no 2622 0.224111532759983 3776 5725375
SGTC_2436 5633522 8.09 µM -0.759021686544355 0.229316625003424 no 2623 0.223919792012949 3738 5724242
SGTC_2505 galangin 7.89 µM -0.759052089667636 0.229307812394729 no 2624 0.22391069870902 3686 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2275 7947463 200 µM -0.759387808809517 0.229210513917387 no 2625 0.223810302050774 3715 1225414
SGTC_2004 4023728 41.89 µM -0.759938584394691 0.229050937712145 no 2626 0.223645648295683 3764 360084 YDR527W RBA50
SGTC_837 0091-0265 12.5 µM -0.761656236146433 0.228553682956234 no 2627 0.223132600791487 3746 759367
SGTC_3285 9112818 20.8695 µM -0.761758563678377 0.228524078608941 no 2628 0.223102057619697 3780 17017947 YPR165W RHO1
SGTC_893 0958-0369 48.9 µM -0.763026997481116 0.228157287303197 no 2629 0.222723647623063 3787 6819948
SGTC_1565 sinapyl alcohol 95.1 µM -0.763182210569108 0.228112427283889 no 2630 0.22267736826266 3781 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1036 k216-0215 33.5 µM -0.765891403531447 0.227330209824559 no 2631 0.221870460677879 3771 622330
SGTC_491 tetrandrine 80.3 µM -0.767169284506394 0.226961776133152 no 2632 0.221490436243619 3741 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1502 4534-4282 27.7 µM -0.767194434026053 0.22695452850162 no 2633 0.221482960853846 3747 3278949
SGTC_56 0957-0365 83.25 µM -0.767269782884153 0.226932815120349 no 2634 0.221460565182808 3743 6752360
SGTC_1658 st012944 20 µM -0.76758132388111 0.226843050372299 no 2635 0.22136798071289 3710 24207260
SGTC_3298 9116858 71.43 µM -0.768586963991704 0.226553430589741 no 2636 0.221069273352258 3811 2506942
SGTC_2697 mebhydrolin 72.4 µM -0.770421566943486 0.226025611434884 no 2637 0.220524932093356 3794 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_3250 9135583 49.47 µM -0.771096884377719 0.225831496350367 no 2638 0.22032475360299 3819 7699353
SGTC_815 1582-0027 36.9 µM -0.771126718536434 0.225822922913625 no 2639 0.220315912525438 3828 3128206
SGTC_192 3455-0609 60.9 µM -0.771400354896041 0.225744296670446 no 2640 0.220234832404415 3858 3769639
SGTC_2148 5546263 113.568 µM -0.771999358430487 0.22557223399728 no 2641 0.220057403742214 3786 792097
SGTC_12 0849-0099 9.267 µM -0.77269757229779 0.225371767044528 no 2642 0.219850691883099 3706 6071388
SGTC_3069 9117009 49.47 µM -0.773544903798717 0.225128621880099 no 2643 0.219599982299718 3733 41904981
SGTC_132 0417-1715 25.805 µM -0.774405599001876 0.22488179416999 no 2644 0.219345486826726 3785 6769098
SGTC_2373 9071805 200 µM -0.7753817278358 0.224602048479292 no 2645 0.219057064466094 3764 10149009
SGTC_1090 efavirenz 20.7 µM -0.776737345420074 0.224213873954332 no 2646 0.218656874381637 3860 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1989 st071868 50.2 µM -0.776764282122526 0.22420616462208 no 2647 0.218648926699639 3792 16414057
SGTC_113 0099-0221 2.5 µM -0.777136626837969 0.224099614322837 no 2648 0.218539083318899 3784 89219
SGTC_2003 4023581 200 µM -0.777553053780797 0.223980483514949 no 2649 0.218416273127711 3837 16641307
SGTC_377 3970-0964 33.1 µM -0.77798505890359 0.223856934158857 no 2650 0.218288910728784 3782 16481235
SGTC_2447 5741742 33.78 µM -0.779553582790522 0.223408677004771 no 2651 0.217826843288264 3846 1776504
SGTC_1594 piperine 70.1 µM -0.779843223931646 0.223325958443371 no 2652 0.217741580392248 3780 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1202 1988-0068 29.6 µM -0.780940487741127 0.223012749201572 no 2653 0.217418748852991 3766 2850480
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.781322379662969 0.222903798508056 no 2654 0.217306455356569 3762 279621
SGTC_2421 5690543 90.72 µM -0.7815973786006 0.222825362305719 no 2655 0.217225613979352 3842 3397993
SGTC_2277 7947813 106.88 µM -0.783098161988615 0.222397580587215 no 2656 0.216784735216721 3899 1246798
SGTC_803 4488-1585 147 µM -0.783828488445185 0.222189578661739 no 2657 0.2165703776052 3834 747204
SGTC_201 4262-0159 12.803 µM -0.784192591681695 0.222085921076963 no 2658 0.216463555738984 3817 1341029
SGTC_2469 5655019 90.81 µM -0.786352357573141 0.221471618992182 no 2659 0.215830543299364 3878 2788239
SGTC_1140 3229-1848 2.98 µM -0.786426648483621 0.221450505728982 no 2660 0.21580878825076 3835 2849525
SGTC_3278 9139605 49.47 µM -0.787470635554317 0.221153929336954 no 2661 0.215503205763094 3823 7958859
SGTC_2546 rhodinyl acetate 100 µM -0.787686846972506 0.221092536301363 no 2662 0.215439950518282 3744 6708682
SGTC_2908 7930301 100 µM -0.787986864611284 0.221007362722779 no 2663 0.21535219460231 3822 2223178
SGTC_1235 benzylparaben 21.5 µM -0.791474606692057 0.220018588459464 no 2664 0.214333544300816 3823 7180
SGTC_2158 5657123 3.6195 µM -0.79166273072162 0.219965327567952 no 2665 0.21427867947407 3774 2858827
SGTC_2208 7283366 200 µM -0.79206917175976 0.219850282935627 no 2666 0.214160172182288 3797 898663
SGTC_454 lyso-paf C-16 6.67 µM -0.794925388546702 0.219042794949147 no 2667 0.213328452386267 3754 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1428 4049-0204 61.7 µM -0.795011446788349 0.219018491713028 no 2668 0.213303421803958 3872 X1428
SGTC_1677 st019204 53.9 µM -0.795027370523756 0.219013994948259 no 2669 0.213298790472837 3857 3945625
SGTC_317 4495-0002 170 µM -0.795211743902509 0.218961932908852 no 2670 0.213245170756369 3851 15991618
SGTC_2412 st077135 33.4 µM -0.795835886724454 0.218785744756737 no 2671 0.213063715044176 3919 13258915
SGTC_1711 st032263 62.8 µM -0.796653452922075 0.218555078935478 no 2672 0.212826162094491 3835 3958979
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.796668079529554 0.218550953501019 no 2673 0.2128219135792 3844 616764
SGTC_1887 st057648 70.8 µM -0.797035589154312 0.21844731213307 no 2674 0.212715181202404 3860 688672
SGTC_2413 inermin 26.06 µM -0.799315242891035 0.217805059781143 no 2675 0.212053821261627 3919 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_306 1672-3436 11.6 µM -0.799638859657559 0.217713974813683 no 2676 0.211960033002045 3835 6797378
SGTC_2217 6934799 96.0675 µM -0.80431417586232 0.216400517606409 no 2677 0.210607776375534 3768 675606
SGTC_1022 4477-0945 21.3 µM -0.808484949376514 0.2152326838131 no 2678 0.209405733387008 3805 4648966
SGTC_715 0868-0130 184 µM -0.810094318256845 0.214783033745948 no 2679 0.208942984773527 3859 2876258
SGTC_2891 9063876 19.48 µM -0.810264900976519 0.214735405751115 no 2680 0.208893971737461 3843 6472478
SGTC_3081 9117243 49.47 µM -0.811248297101426 0.214460953755985 no 2681 0.208611547497918 3879 45595589
SGTC_37 0566-0070 1.56 µM -0.812364552371231 0.214149669936908 no 2682 0.208291239999599 3855 1626686
SGTC_1748 st037455 53.6035 µM -0.812539436844235 0.214100924721578 no 2683 0.208241083508172 3858 580690
SGTC_2067 5224629 34.075 µM -0.813848367128935 0.213736294155905 no 2684 0.207865911433111 3837 2835000
SGTC_2395 5646831 180.19 µM -0.815195226338053 0.213361475520807 no 2685 0.207480284961118 3857 6808628
SGTC_2260 7964312 200 µM -0.815445377679381 0.213291902901589 no 2686 0.207408709380104 3891 231951
SGTC_1290 0986-0249 10.2 µM -0.815642013703381 0.213237223362176 no 2687 0.207352456337386 3778 53329
SGTC_812 4251-0442 148 µM -0.816245475077038 0.213069466956914 no 2688 0.207179876250709 3821 5723007
SGTC_291 SEC14.278 35.5 µM -0.817809557462718 0.212635025779724 no 2689 0.206732969908357 3846 1068044
SGTC_3102 9121669 49.47 µM -0.818580505089162 0.212421077019845 no 2690 0.206512896680277 3863 41905072
SGTC_1066 ketoconazole 628 nM -0.819956760653084 0.212039459664786 no 2691 0.206120378590296 3931 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2117 5521686 200 µM -0.820784347360088 0.21181017404409 no 2692 0.205884557973386 3825 803312
SGTC_463 ikarugamyin 104 µM -0.822454556211094 0.211347879259232 no 2693 0.205409120144114 3903 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2929 9013348 24.6 µM -0.822472114709997 0.21134302240814 no 2694 0.205404125447869 3897 2995952
SGTC_3170 9103054 49.47 µM -0.822498772114543 0.211335648836477 no 2695 0.205396542611881 3885 16432970
SGTC_1034 k072-0165 12.7 µM -0.822829958717879 0.211244053529218 no 2696 0.205302348741511 3881 5835461
SGTC_898 1000-0849 28.3 µM -0.824261842907827 0.210848309276057 no 2697 0.204895397253101 3839 6751807
SGTC_2842 9000675 19.48 µM -0.827227567199701 0.21003002638637 no 2698 0.204054044721659 3919 2989072
SGTC_1903 st060211 78.3 µM -0.827494194710005 0.209956551828699 no 2699 0.203978505573234 3931 688960
SGTC_1120 ficusin 1.78878 µM -0.827652917133289 0.209912819855156 no 2700 0.203933545295527 3979 6199 A DNA cross-linker.
SGTC_881 0833-0569 170 µM -0.82828593323424 0.209738461441855 no 2701 0.203754293654431 3875 5418700
SGTC_218 alverine citrate 93.75 µM -0.82844530884433 0.209694576330483 no 2702 0.203709177949554 3903 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1583 clindamycin 39.6 µM -0.829238668998436 0.209476199801166 no 2703 0.203484683895307 3844 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_525 k781-2675 26.7 µM -0.830549777346003 0.209115603781179 no 2704 0.203114008268459 3869 3651118 YDL195W SEC31
SGTC_1832 st054113 55 µM -0.830627011434788 0.209094373384055 no 2705 0.203092185281751 3857 1251267
SGTC_2757 clomiphene 4.22 µM -0.831644061786889 0.208814921175653 no 2706 0.202804941801713 3919 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_366 0181-0206 4.31 µM -0.832616357463892 0.208547971957724 no 2707 0.20253056535284 3844 274874
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.832910508159684 0.208467250900082 no 2708 0.202447601400449 3883 688662
SGTC_3010 9080089 71.4286 µM -0.833809370144233 0.208220698713745 no 2709 0.202194207153543 3883 17027233
SGTC_170 4197-0004 226 µM -0.836281371318448 0.20754353220021 no 2710 0.201498315277525 3922 218692
SGTC_397 arbidol 50 µM -0.836312622206055 0.207534979841579 no 2711 0.20148952705116 3937 131410 A RNA synthesis inhibitor.
SGTC_2347 9049783 174.81 µM -0.838097602733482 0.207046834098139 no 2712 0.200987944595443 3922 6467988 YPL169C MEX67
SGTC_2868 9035608 32.47 µM -0.838474097343534 0.206943959436776 no 2713 0.20088224473072 3858 6462614
SGTC_839 0122-0028 230 µM -0.839431138834294 0.20668259039703 no 2714 0.200613708067392 3876 759448
SGTC_3348 9149464 3.537 µM -0.840986808738499 0.206258152670181 no 2715 0.200177662209821 3865 1951442
SGTC_819 1013-0258 27.7 µM -0.841219365633751 0.206194747946656 no 2716 0.200112526745328 3904 5753198
SGTC_1687 st020778 55.3625 µM -0.841739152326966 0.206053074163479 no 2717 0.199966988877327 3891 4259299
SGTC_2398 5228213 48.84 µM -0.845164226744145 0.205120975455861 no 2718 0.199009576286871 3895 80771 YMR134W ERG29
SGTC_1077 5-fluorocytosine 377 nM -0.84562739300749 0.204995122148158 no 2719 0.198880319565321 3917 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2185 6113692 200 µM -0.850116188196999 0.203777789497868 no 2720 0.197630246154903 3913 874150
SGTC_844 0330-0132 15.3 µM -0.851677579388273 0.203355362401079 no 2721 0.19719653395622 3943 2828079
SGTC_1123 mangostin 811.285 nM -0.853024860000883 0.20299128220864 no 2722 0.196822759101244 3931 5281650 An antioxidant.
SGTC_1526 st051518 75 µM -0.856530788284658 0.202045689595061 no 2723 0.195852125190275 3923 673993
SGTC_3066 9117245 49.47 µM -0.856855472557453 0.201958251767314 no 2724 0.195762381910483 3975 17176980
SGTC_2153 5569715 200 µM -0.860849825308912 0.200884422680279 no 2725 0.194660379489616 3935 2054701
SGTC_883 0850-0245 24.6 µM -0.861470360573926 0.200717907956885 no 2726 0.194489519312205 4012 6823229 YPR165W RHO1
SGTC_2965 9082772 38.63 µM -0.862071722271237 0.200556617355424 no 2727 0.194324025570717 3909 16459634
SGTC_1625 st003711 30.1 µM -0.863610611934238 0.200144227904813 no 2728 0.193900916312618 3978 24207034 YER133W GLC7
SGTC_1381 2324-0066 62.1 µM -0.863861387168934 0.200077073843236 no 2729 0.193832020280572 3987 10885928
SGTC_471 1-acyl-paf 4 µM -0.864551797703358 0.199892261655478 no 2730 0.193642419379433 3855 16759367
SGTC_1784 st039334 36.3 µM -0.86491132970062 0.199796061183115 no 2731 0.193543729312252 4001 3496984
SGTC_3234 9132280 49.47 µM -0.864997404134177 0.199773034260558 no 2732 0.193520106783456 3965 17612295
SGTC_2137 5261020 140 µM -0.86540664403103 0.199663574864996 no 2733 0.193407817803922 3888 763655
SGTC_3195 9113082 49.47 µM -0.866400260438387 0.199397962498937 no 2734 0.193135350591279 3831 17018038
SGTC_2304 7443016 91.4 µM -0.868889157463091 0.198733567952748 no 2735 0.192453880296721 3858 939854
SGTC_1798 st045719 60.953 µM -0.870577680280482 0.198283588882649 no 2736 0.191992393852111 3823 3980186
SGTC_1836 st055642 81 µM -0.871721400876726 0.197979145275541 no 2737 0.191680191169488 3943 8571
SGTC_3115 9123671 49.47 µM -0.872060671925245 0.1978888900405 no 2738 0.191587639801773 4026 3286988
SGTC_1522 st012842 45.6 µM -0.873119234494071 0.197607443695426 no 2739 0.1912990454595 3809 3491067 YOR116C RPO31
SGTC_1951 sophoraflavanone G 9.2 µM -0.873405323624585 0.197531421024677 no 2740 0.191221095165325 3910 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_790 1575-0012 79.1 µM -0.874179123357313 0.197325887272935 no 2741 0.191010356643308 4019 378741 YLR208W SEC13
SGTC_1924 st058459 75.1 µM -0.875534292754203 0.19696624410223 no 2742 0.190641629817401 3888 688683
SGTC_1484 3473-2379 286 µM -0.875655978731831 0.196933969756353 no 2743 0.190608541779699 4040 671917
SGTC_1340 1486-1359 257 µM -0.877165030652693 0.196533995280707 no 2744 0.190198503457519 3879 4309068
SGTC_1373 2887-0003 58.5 µM -0.877645693870106 0.196406698842444 no 2745 0.190068011938944 3924 776948
SGTC_2893 9048488 25.97 µM -0.878213206852536 0.196256465896835 no 2746 0.189914013105178 3977 6467338
SGTC_2620 irigenin 100 µM -0.878765809733615 0.196110246947015 no 2747 0.189764133973276 3998 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1293 1000-1278 195 µM -0.879093800803819 0.196023491628706 no 2748 0.189675209353014 3993 678847
SGTC_204 PMA1.184 62.41 µM -0.879349588249799 0.195955850698949 no 2749 0.189605878301296 3972 2252213 YGL008C PMA1
SGTC_1144 3486-0183 12.5 µM -0.880644827634564 0.195613552529911 no 2750 0.18925504376064 3938 6744069
SGTC_2967 9089538 49.85 µM -0.880949734836718 0.195533026286769 no 2751 0.189172513335437 3990 728216
SGTC_420 mitomycin C 81.9 mM -0.881685104205982 0.195338897469047 no 2752 0.188973559228249 3925 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_635 k038-0028 24.7 µM -0.882009981294909 0.195253171063666 no 2753 0.188885704833026 3952 4035102
SGTC_1628 st004252 77.7 µM -0.882819581502665 0.19503963863584 no 2754 0.18866687944591 3981 692968
SGTC_3194 9111903 49.47 µM -0.883526186959517 0.194853387192716 no 2755 0.188476020099969 3968 17087251
SGTC_2541 muurolladie-3-one 83.07 µM -0.883678039444277 0.194813375099638 no 2756 0.188435019173061 3987 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_3093 9117344 49.47 µM -0.885070818642516 0.194446620453626 no 2757 0.188059218515423 3987 24824913
SGTC_2705 st078069 42.8 µM -0.885228684445642 0.194405076855922 no 2758 0.188016652262686 4005 1530061
SGTC_589 1227-0070 34.1 µM -0.88715746873394 0.193897938885774 no 2759 0.187497063566348 3994 2841384
SGTC_53 0973-0023 39.979 µM -0.887826993452015 0.193722088494753 no 2760 0.187316910237116 3855 674768
SGTC_1006 4099-6547 255 µM -0.888204530828106 0.193622971346742 no 2761 0.187215371025834 3989 3146833
SGTC_3316 9136639 10.545 µM -0.888348188457277 0.193585264173361 no 2762 0.187176743044668 3972 4903665
SGTC_2429 5902844 64.44 µM -0.889278023740124 0.193341309855287 no 2763 0.186926839619054 3995 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1160 4092-0570 10.5 µM -0.891078396170963 0.192869492413406 no 2764 0.186443556985802 3946 4994975
SGTC_1852 st056254 31.4 µM -0.891689358051981 0.192709539691205 no 2765 0.186279729587411 3900 442583
SGTC_356 1634-0012 32.5 µM -0.891821005919422 0.192675084272047 no 2766 0.186244440333301 3954 735457
SGTC_3086 9117350 49.47 µM -0.893810787649519 0.192154769011823 no 2767 0.185711568171492 3906 2679265
SGTC_1856 st057054 55.7 µM -0.893954219520255 0.192117295736064 no 2768 0.185673193077485 3980 1266018
SGTC_71 0417-1750 47.813 µM -0.894988627800376 0.191847176737006 no 2769 0.185396583588016 3957 6811472
SGTC_506 n9-isopropylolomoucine 153 µM -0.895652305174397 0.191673990628755 no 2770 0.185219245459078 3960 6610355
SGTC_938 3126-1755 342 µM -0.8971207860777 0.191291132102187 no 2771 0.184827234115964 3989 1777771
SGTC_1634 st006576 41 µM -0.899218937704335 0.190744921461165 no 2772 0.184268027546248 3959 3915356
SGTC_2921 7974240 10.71 µM -0.89988711520644 0.190571176318458 no 2773 0.184090163851075 4069 2979074 YDR527W RBA50
SGTC_2135 5326629 150.42 µM -0.900003972426319 0.190540800104561 no 2774 0.184059068344599 3939 5020077
SGTC_3039 9090270 49.47 µM -0.902060006753689 0.190006834786771 no 2775 0.183512496133224 3967 17173750
SGTC_1137 ixabepilone 100 µM -0.902186280707312 0.189974070636474 no 2776 0.183478960714177 3937 154225 A novel microtubule stabilizer.
SGTC_705 1124-0212 310 µM -0.902845404686765 0.189803104915605 no 2777 0.183303974763336 3917 9554485
SGTC_3255 9139072 49.47 µM -0.903004285962994 0.189761907929862 no 2778 0.183261810118856 3966 17646060
SGTC_2426 5582046 32.21 µM -0.904701863470434 0.189322079350692 no 2779 0.182811676813676 3989 2251934
SGTC_3075 9116269 49.47 µM -0.905211933836304 0.18919004695402 no 2780 0.182676560409629 4006 17015205 YNL244C SUI1
SGTC_1749 st037932 54.2 µM -0.913719752498922 0.186996154102959 no 2781 0.180432061106334 4052 594497
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.914049974298125 0.186911319046559 no 2782 0.18034529350966 3986 4620898
SGTC_2302 7771753 200 µM -0.915210025040922 0.186613487054643 no 2783 0.180040691369546 3999 2203047
SGTC_1119 parthenolide 318.541 nM -0.916595432904339 0.186258182024414 no 2784 0.179677339242537 4103 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_3311 9131146 2.8755 µM -0.916727779797871 0.186224261970772 no 2785 0.17964265263463 3963 4900406 YPR165W RHO1
SGTC_2009 4012297 12.05 µM -0.918137335248892 0.185863235290758 no 2786 0.179273485361668 4009 45595307
SGTC_1790 st045711 43.5 µM -0.918270032117021 0.185829270271029 no 2787 0.17923875619735 3973 585119
SGTC_1115 galangin 695.678 nM -0.921731564666908 0.184944618653394 no 2788 0.178334305894431 4037 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_599 1935-0052 86.5 µM -0.921732529901344 0.184944372337381 no 2789 0.178334054093834 3986 9557311
SGTC_418 lividomycin a 100 µM -0.922328617066285 0.184792297125923 no 2790 0.178178595692292 3989 72394 An antibiotic.
SGTC_1003 4049-0218 100 µM -0.924743662558009 0.184176960577858 no 2791 0.177549630867099 4041 295161
SGTC_1555 citronellol 128 µM -0.92528173120463 0.184040038401682 no 2792 0.177409689522407 3935 8842 A terpine precursor.
SGTC_1023 4482-3888 16 µM -0.927187282056462 0.183555643242641 no 2793 0.176914652441103 4031 3303168
SGTC_3045 9092950 49.47 µM -0.927448899565701 0.183489201592227 no 2794 0.17684675586591 3951 44120432
SGTC_2861 9024595 19.48 µM -0.928784097305944 0.18315034183641 no 2795 0.176500493760258 3893 16482810
SGTC_1369 1866-0067 208 µM -0.929197902628168 0.183045401493013 no 2796 0.176393267095742 4000 3531355
SGTC_982 1491-0518 27.5 µM -0.929956239733025 0.182853185851635 no 2797 0.176196871157619 3932 3091256
SGTC_1672 st016598 6.51 µM -0.930241746785013 0.182780851059854 no 2798 0.176122965740622 4039 4665860 YNL267W PIK1
SGTC_2273 7815444 169.05 µM -0.930606591914892 0.182688441529235 no 2799 0.176028551694058 3965 2824616
SGTC_220 paclitaxel 373.376 µM -0.933472551864066 0.181963553890241 no 2800 0.17528801797078 3976 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2830 7992007 71.43 µM -0.933536115941896 0.181947497034425 no 2801 0.175271616109963 3898 1952075
SGTC_851 0394-0702 453 µM -0.933665032156286 0.18191493436406 no 2802 0.175238353992248 4015 762646
SGTC_944 3370-0224 231 µM -0.933924469447738 0.181849414702798 no 2803 0.17517142781565 4058 4580514
SGTC_3080 9117754 49.47 µM -0.934612158025442 0.181675813631306 no 2804 0.174994105528179 4018 9550191
SGTC_2585 alliin 100 µM -0.934992907012834 0.181579741437237 no 2805 0.174895977414154 4077 87310 A garlic compound which reacts with lipids.
SGTC_2523 spermine 47.74 µM -0.935178488157536 0.181532926345811 no 2806 0.174848161378372 4027 1103 A DNA binding polyamine.
SGTC_26 0302-0163 425.158 µM -0.938041445589146 0.180811668136921 no 2807 0.174111555675323 4063 3100915
SGTC_2033 5192550 145 µM -0.939053155410587 0.180557220581531 no 2808 0.173851726859082 3999 182073
SGTC_245 methotrexate 289.6 µM -0.939466971713551 0.180453209491252 no 2809 0.173745521040612 3994 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_529 4076-0302 30.3 µM -0.940832293552949 0.180110307905291 no 2810 0.173395404437233 3967 5816522
SGTC_597 k018-0003 82.8 µM -0.941398147881797 0.179968313148757 no 2811 0.173250431191749 4084 6786234
SGTC_568 1193-0097 7.48 µM -0.942021353881127 0.179812008007633 no 2812 0.173090853650093 3882 3646150
SGTC_3038 9091290 49.47 µM -0.94245390304849 0.179703571302405 no 2813 0.172980150577723 4033 25236843
SGTC_2084 5306078 60.6385 µM -0.942524850525618 0.179685789245897 no 2814 0.172961997171776 3955 679340
SGTC_1073 triclabendazole 3.09 µM -0.943497163498719 0.17944220313701 no 2815 0.172713332739954 4094 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1411 3909-8223 150 µM -0.943641180187841 0.179406141399783 no 2816 0.172676520541676 4039 X1411
SGTC_2742 clothiapine 36.27 µM -0.944388292670215 0.179219137786397 no 2817 0.172485630931155 3980 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_592 k241-0073 46.5 µM -0.945828213318177 0.178859069009609 no 2818 0.172118106447692 4029 4230158
SGTC_348 k064-0012 10.7 µM -0.946724081942965 0.178635276656942 no 2819 0.171889697884853 3924 5066323
SGTC_2329 6138490 200 µM -0.946848162426818 0.178604294654929 no 2820 0.171858077882553 4160 720019
SGTC_852 0418-0143 439 µM -0.947710034093085 0.17838918491132 no 2821 0.171638545664911 4052 5369229
SGTC_536 3852-0578 10.6 µM -0.948604023046814 0.178166231735114 no 2822 0.171411022056303 4091 2869208
SGTC_1827 berberine 7.24 µM -0.948765309121794 0.178126027081777 no 2823 0.171369994669262 3975 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1608 st001473 40.5 µM -0.949464042244854 0.177951916157809 no 2824 0.171192325894281 4011 7292267
SGTC_2002 4023503 131 µM -0.950177268574018 0.177774304527748 no 2825 0.171011093414053 4015 4736863 YCR052W RSC6
SGTC_2012 4023501 200 µM -0.951516405697257 0.17744112729792 no 2826 0.170671147219616 4055 3477460
SGTC_1349 flufenamic acid 69 µM -0.951688218641805 0.177398408798356 no 2827 0.170627563035289 3953 3371 A non-steroidal anti-inflammatory.
SGTC_1297 1068-0111 14.1 µM -0.953805323833257 0.176872557988116 no 2828 0.170091097026174 3991 767057
SGTC_265 mycophenolic acid 32.932 µM -0.953895504151881 0.176850180718377 no 2829 0.170068269722095 4122 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.953958626158824 0.176834518740383 no 2830 0.170052292844676 4016 140250 A respiratory chain inhibitor.
SGTC_1200 1643-0193 18.4 µM -0.954153247439507 0.176786234378204 no 2831 0.17000303810396 4044 5403974
SGTC_1433 4060-0023 7.6 µM -0.956472705771815 0.176211432454904 no 2832 0.169416733787867 4055 3840627
SGTC_477 mead ethanolamide 10 µM -0.956750531015955 0.176142661962053 no 2833 0.169346593253019 3938 16061185
SGTC_2133 5320837 200 µM -0.958184385584978 0.175788007971886 no 2834 0.16898489471661 4085 2841355
SGTC_1364 1653-0028 37.6 µM -0.959005799304388 0.175585040913004 no 2835 0.168777911834911 4031 5718652
SGTC_1917 st066507 28.5 µM -0.962931843818753 0.174616988121659 no 2836 0.16779086391162 4021 3156428
SGTC_2520 obtusaquinone 4.71 µM -0.965914007490536 0.173883939219653 no 2837 0.167043606266938 4100 5967872
SGTC_1454 4239-0054 42.6 µM -0.967676100540159 0.173451718382013 no 2838 0.166603078827809 4161 1340767
SGTC_3189 9110682 49.47 µM -0.968378856431551 0.173279531485118 no 2839 0.16642759753228 4151 17122418
SGTC_2961 9083290 32.55 µM -0.969396697805315 0.173030336442462 no 2840 0.166173649648158 3990 17741490
SGTC_1012 4112-3522 18 µM -0.969710631749365 0.172953523028492 no 2841 0.166095374754659 4077 3112398
SGTC_266 formosanin C 406 nM -0.970434321698244 0.172776533227845 no 2842 0.165915023887828 3950 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2528 xanthyletin 44.79 µM -0.971208363369487 0.172587356937313 no 2843 0.165722264997162 4092 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2760 etidronate 98.04 µM -0.973427428159599 0.172045748450074 no 2844 0.165170456240583 4022 3305 A chelator and antioxidant.
SGTC_1495 4469-0029 237 µM -0.978206758891924 0.170882943572244 no 2845 0.163986037140074 4074 793680
SGTC_199 4063-0024 41.6 µM -0.97823854514809 0.170875226889857 no 2846 0.163978178326199 4091 306215
SGTC_3144 9087057 49.47 µM -0.978640788040716 0.170777594495594 no 2847 0.163878749160055 3897 17249618
SGTC_458 nppb 133 µM -0.980067597021818 0.170431567407802 no 2848 0.163526376293777 4092 4549 A chloride channel blocker.
SGTC_2898 9056270 58.44 µM -0.980574756181402 0.170308680346191 no 2849 0.163401243998445 4014 19154699
SGTC_929 2805-0021 398 µM -0.981187092155015 0.170160384103859 no 2850 0.163250244142792 4131 3098024
SGTC_2397 5161689 200 µM -0.981678892412326 0.170041339276992 no 2851 0.16312903363592 4128 2259942
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.985343636861956 0.169155935324477 no 2852 0.162227652547957 4121 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2770 toltrazuril 17.5 µM -0.985759100406863 0.169055746294853 no 2853 0.162125670113317 3961 68591 Kills coccidiodes.
SGTC_2629 bisabolol 100 µM -0.986061574548689 0.168982828636702 no 2854 0.162051449073745 4113 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_168 3970-0862 530.542 µM -0.987963721912689 0.168524739680139 no 2855 0.161585207826755 4049 3135186
SGTC_2166 5933061 31.504 µM -0.988035425042255 0.168507487240838 no 2856 0.16156764957047 4188 2877375
SGTC_2999 9069765 71.4286 µM -0.990544892912851 0.167904401345008 no 2857 0.160953928858734 4061 2097066
SGTC_3172 9105863 49.47 µM -0.992450803550415 0.167447294402553 no 2858 0.160488833400512 4105 2348785
SGTC_2282 7944268 200 µM -0.993355616174097 0.167230568256061 no 2859 0.160268341502424 4115 2970414
SGTC_1730 st033808 45.1 µM -0.993470887157351 0.167202970849589 no 2860 0.160240265582828 4026 1045166
SGTC_2648 atorvastatin 78.68 µM -0.994562108056155 0.166941863511551 no 2861 0.159974642185391 4093 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.997047132811757 0.166348228745475 no 2862 0.159370816265619 4115 5379071
SGTC_2319 6033012 152.6 µM -0.997414176894115 0.166260663152827 no 2863 0.159281756387307 4042 847246
SGTC_1500 4488-1866 171 µM -0.997584188223706 0.166220113692882 no 2864 0.159240515744885 4138 2900003
SGTC_163 TUB2.036 7.546 µM -0.99825970221995 0.166059059740816 no 2865 0.159076721466657 4071 15992207 YJR013W GPI14
SGTC_1501 4491-0275 38.4 µM -0.998856648766088 0.165916821542891 no 2866 0.158932069616234 4037 5104718
SGTC_966 1300-0360 30.2 µM -1.00158421285807 0.165267909945555 no 2867 0.158272224438908 4072 70588
SGTC_736 0958-0254 92.6 µM -1.00289681356282 0.164956216809837 no 2868 0.157955325105599 4194 6812352
SGTC_319 1348-1596 45.5 µM -1.00327904662924 0.164865522491427 no 2869 0.157863121492894 4186 5380505
SGTC_3166 9102297 49.47 µM -1.00396842985261 0.164702030811749 no 2870 0.157696915409994 4108 25237072
SGTC_1311 1190-0148 100 µM -1.0040795982941 0.164675676336862 no 2871 0.157670124145079 4159 1961333
SGTC_801 0866-0028 10.1 µM -1.0043993060751 0.164599899096337 no 2872 0.157593092183408 4092 6849771
SGTC_1170 0310-0127 64.8 µM -1.00546028069864 0.164348588496516 no 2873 0.157337632974908 4116 774975
SGTC_805 3852-0218 479 µM -1.00649274347547 0.164104270388158 no 2874 0.157089300277587 4050 6615355
SGTC_2594 a-mangostin 100 µM -1.00800619772502 0.163746558277675 no 2875 0.156725743449751 4134 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1561 5-methoxyflavone 52.9 µM -1.00899436454937 0.16351327367423 no 2876 0.156488668438787 4016 94525
SGTC_464 bw-b 70c 158 µM -1.00960887402547 0.163368310307433 no 2877 0.15634135818429 4144 5353454
SGTC_1291 0993-0025 5.79 µM -1.00997877461648 0.163281090672192 no 2878 0.156252729639678 4112 4353356
SGTC_1879 gemcitabine 100 µM -1.0100172777466 0.163272013677277 no 2879 0.156243506154202 4060 60750 A nucleoside analog which inhibits DNA replication.
SGTC_842 0271-0008 11.1 µM -1.01102490922564 0.16303458420718 no 2880 0.156002253965362 4153 1221709
SGTC_2813 7971799 71.43 µM -1.01303756141778 0.162561012650579 no 2881 0.155521110019008 4142 2234054
SGTC_2982 9019404 25.97 µM -1.01410404600466 0.162310434895997 no 2882 0.155266553811369 4044 22333232
SGTC_2490 carminic acid 95.39 µM -1.01534643130088 0.162018845316022 no 2883 0.154970359335841 4073 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2806 7952793 58.44 µM -1.01578693655297 0.161915540098966 no 2884 0.154865429070423 4182 2972490
SGTC_2095 5432005 200 µM -1.01662932023639 0.161718107765797 no 2885 0.154664900330222 4114 783734
SGTC_2790 5423970 71.43 µM -1.01768277184946 0.161471427609051 no 2886 0.154414368605051 4167 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2934 9036370 36.88 µM -1.01928551552834 0.16109659403119 no 2887 0.15403371920781 4103 6462800
SGTC_2380 9035439 200 µM -1.02380705020114 0.160042205808067 no 2888 0.152963209855419 4219 6462575
SGTC_3157 9099274 49.47 µM -1.02458906653293 0.159860304178485 no 2889 0.152778562787577 4148 17217662
SGTC_1222 0366-0074 1.18 µM -1.02545929643962 0.15965804259382 no 2890 0.152573260879232 4131 286520
SGTC_48 0382-0018 55 µM -1.02675802719984 0.159356499077971 no 2891 0.152267208976049 4169 762596
SGTC_953 1188-0045 9.7 µM -1.02745571169895 0.159194662503647 no 2892 0.152102964799679 4137 6144426
SGTC_33 0986-0033 35.816 µM -1.03558556842942 0.157316779956965 no 2893 0.150197763773099 4084 2848082
SGTC_77 0828-0286 12.516 µM -1.0374339394049 0.156891872385845 no 2894 0.149766833964933 4049 745345
SGTC_2122 5258151 111.688 µM -1.03894298017488 0.156545531194038 no 2895 0.149415627836552 4128 2173356
SGTC_1309 pyrazolanthrone 13.4 µM -1.04064952574765 0.156154467479739 no 2896 0.149019118405636 4113 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_23 0213-0011 39.996 µM -1.04161751283429 0.155932934597361 no 2897 0.148794522971211 4137 627608
SGTC_2882 9058044 58.44 µM -1.0425281778699 0.155724709623332 no 2898 0.148583434212331 4171 18076804
SGTC_261 5-fluorouridine 15.376 µM -1.04260004327243 0.155708285297033 no 2899 0.148566784607794 4152 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2405 ticlatone 3.52 µM -1.044246214776 0.155332377309357 no 2900 0.148185745073733 3976 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2471 5466956 24.79 µM -1.04441052404922 0.155294889715541 no 2901 0.148147748307402 4114 724419
SGTC_3323 9138564 53.9225 µM -1.04522221201458 0.155109788580273 no 2902 0.14796013990302 4155 43912313 YNL103W MET4
SGTC_877 0771-0151 33.1 µM -1.04533566806169 0.155083927138761 no 2903 0.147933929066118 4155 6166523
SGTC_1163 k060-0048 49.9 µM -1.04557230834327 0.155029995951788 no 2904 0.14787926997048 4126 6809982
SGTC_2919 7978188 46.38 µM -1.04572332895939 0.154995584274772 no 2905 0.147844394346054 4157 2980291
SGTC_283 0987-0079 11.7 µM -1.04818595140997 0.154435160970956 no 2906 0.147276470929448 4141 411556
SGTC_1809 st050081 57.6 µM -1.05202515472803 0.153564142142768 no 2907 0.146394004411231 4232 5036894
SGTC_1187 1391-0724 117 µM -1.05334994818939 0.153264336212553 no 2908 0.146090317345475 4184 6997986
SGTC_3027 9089541 49.47 µM -1.05528144349543 0.152827926655967 no 2909 0.145648312677621 4160 9943819
SGTC_1318 1280-3875 124 µM -1.05759012180254 0.152307377111149 no 2910 0.145121173984097 4143 373245
SGTC_2205 7238770 200 µM -1.06077459961163 0.1515912901749 no 2911 0.144396174108659 4221 279867
SGTC_2344 7990960 76.95 µM -1.0614044180841 0.151449929715886 no 2912 0.144253074974646 4131 140813
SGTC_1450 4112-4260 37.6 µM -1.0624234044222 0.151221407627777 no 2913 0.144021756712423 4153 1633175
SGTC_1816 st051957 91.6 µM -1.06261927340182 0.151177507537406 no 2914 0.1439773215264 4143 674121
SGTC_1609 st001574 46.4 µM -1.06418656527897 0.150826535972146 no 2915 0.143622095924588 4132 3960012
SGTC_2811 7967822 32.47 µM -1.06680856648657 0.150240591758466 no 2916 0.143029144726486 4214 2232244
SGTC_3058 9093861 49.47 µM -1.06712753062552 0.150169415802898 no 2917 0.142957125743386 4175 17217477
SGTC_1382 3002-2117 298 µM -1.06771276979671 0.150038879780205 no 2918 0.14282504820217 4239 1497314
SGTC_2889 9059656 51.95 µM -1.07341961094248 0.14876995059727 no 2919 0.141541444727434 4237 3949838
SGTC_1764 st044502 93.5 µM -1.07357703494988 0.148735048967025 no 2920 0.141506147479757 4209 8407
SGTC_3209 9113616 49.47 µM -1.07407715915555 0.148624205432257 no 2921 0.141394050360685 4230 16649353
SGTC_940 3232-1287 54.8 µM -1.07463064257879 0.148501600179249 no 2922 0.141270063559322 4128 1585493 YIL048W NEO1
SGTC_565 1418-0001 44.5 µM -1.07475901931506 0.148473172385526 no 2923 0.141241316192615 4246 2862145
SGTC_3290 9121031 71.43 µM -1.07775303417987 0.147811208720927 no 2924 0.140571991998253 4185 17014854
SGTC_1174 0739-0097 51.1 µM -1.07929106016493 0.147471927343315 no 2925 0.14022899845418 4205 728447
SGTC_1420 4'-methoxyflavone 42 µM -1.07940597886738 0.147446597778843 no 2926 0.140203393399082 4159 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3084 9116877 49.47 µM -1.07954381687458 0.147416220349244 no 2927 0.140172685879131 4108 27241325
SGTC_1102 cgs 12066b 26.1 µM -1.0808821194361 0.14712149656726 no 2928 0.139874776663138 4173 6438352 A 5-HT1B full agonist.
SGTC_704 1310-0270 142 µM -1.08355528914111 0.146533988908355 no 2929 0.139281011995444 4185 5718033
SGTC_1834 st055981 52.8 µM -1.0836489107108 0.146513441396232 no 2930 0.139260247895865 4187 471719 YDL150W RPC53
SGTC_1402 3909-7673 35.9 µM -1.08405728033988 0.146423837445984 no 2931 0.139169701224852 4180 5328014
SGTC_2102 5377816 72.7585 µM -1.08520522980645 0.146172152916262 no 2932 0.138915384216303 4227 1379702
SGTC_3304 9125678 46.087 µM -1.08675219898596 0.145833444372539 no 2933 0.138573169102094 4117 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_680 0417-1641 114 µM -1.08778114694322 0.14560844879535 no 2934 0.138345867171532 4163 2835990
SGTC_1797 st048695 56.8 µM -1.08796434685337 0.145568413758126 no 2935 0.138305423674212 4146 592262 YIL048W NEO1
SGTC_2950 9072895 21.46 µM -1.09255020851356 0.144568667879684 no 2936 0.137295667202524 4155 17332245
SGTC_1142 3253-1408 9.78 µM -1.09259510046955 0.144558904076956 no 2937 0.137285807435016 4204 256655
SGTC_1976 st070609 63.5 µM -1.09335367625742 0.144393984363907 no 2938 0.137119272072137 4104 682556
SGTC_358 0075-0058 9.45 µM -1.09466786372401 0.144108570987265 no 2939 0.136831086230341 3995 1069125
SGTC_967 1306-0166 352 µM -1.09556503919038 0.143913942326181 no 2940 0.136634584171275 4207 4437607
SGTC_1849 st056239 19.2 µM -1.09684031925915 0.143637594857218 no 2941 0.136355600733082 4194 5393181
SGTC_3116 9124943 49.47 µM -1.1002433636737 0.142901924254131 no 2942 0.135613050736515 4178 41905195 YPL160W CDC60
SGTC_2630 antimycin a 100 µM -1.10087620177904 0.14276539852869 no 2943 0.135475270464515 4141 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1405 3909-7894 12 µM -1.10530105902342 0.141813263170432 no 2944 0.134514579600004 4195 7104060
SGTC_1921 5740136 50 µM -1.10629614923184 0.141599734530414 no 2945 0.134299178990507 4162 1774243
SGTC_1562 morin hydrate 59.1 µM -1.10634432726377 0.141589401913761 no 2946 0.134288756225259 4248 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2941 9056145 11.23 µM -1.10707243058489 0.141433309690211 no 2947 0.134131307048882 4128 2119517
SGTC_1808 st050063 61.5 µM -1.10854068334081 0.141118897581788 no 2948 0.133814189610045 4192 4011993
SGTC_2443 5493264 126.67 µM -1.10912035108651 0.140994897942969 no 2949 0.133689133314633 4242 5340055
SGTC_1259 0671-0132 43 µM -1.1107815036484 0.140639961882399 no 2950 0.133331204932062 4132 X1259
SGTC_2207 7258803 200 µM -1.11230809437578 0.140314312620001 no 2951 0.133002852403022 4192 3666799
SGTC_1203 3992-3522 103 µM -1.11329480074461 0.140104103066456 no 2952 0.132790919348947 4330 5322312
SGTC_1105 epirubicin 18.1 µM -1.11395310154221 0.139963976625555 no 2953 0.132649653398817 4239 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2015 5119600 184 µM -1.11414729383479 0.139922658894416 no 2954 0.132608001106168 4246 2828786
SGTC_2278 7948257 134.34 µM -1.11770974476618 0.139166157300169 no 2955 0.131845489738147 4209 1247028
SGTC_3279 9140807 49.47 µM -1.1177107515072 0.139165943908622 no 2956 0.131845274682452 4254 45595718
SGTC_1215 3852-0577 11.2 µM -1.11802264091363 0.139099845707678 no 2957 0.131778661855826 4253 2884876
SGTC_2047 4141938 200 µM -1.12031109814477 0.138615510432686 no 2958 0.131290607174099 4213 3807862
SGTC_2801 7907800 81.82 µM -1.12155815580525 0.13835206397106 no 2959 0.131025175768387 4230 6620925
SGTC_1885 st057546 99.9 µM -1.12179698314209 0.138301649600743 no 2960 0.130974384623135 4238 702008
SGTC_149 3970-0822 46.1 µM -1.12266366764691 0.138118805238645 no 2961 0.130790182059588 4212 3114250 YBL034C STU1
SGTC_785 1270-0111 65.3 µM -1.12507367818275 0.137611232285664 no 2962 0.130278907097545 4143 6741994
SGTC_2955 9076254 12.21 µM -1.12891530825344 0.136804780639169 no 2963 0.129466781185604 4136 16459619
SGTC_3034 9090421 49.47 µM -1.12962546534206 0.136656055909524 no 2964 0.129317037979687 4123 17173761
SGTC_534 k292-0788 63.4 µM -1.12962669600054 0.136655798274725 no 2965 0.129316778588168 4274 4146317
SGTC_2075 5212009 200 µM -1.13088233802311 0.136393106266613 no 2966 0.129052309033106 4140 780898
SGTC_159 3970-0959 50 µM -1.13114897957216 0.136337366867926 no 2967 0.128996195977768 4295 6615653
SGTC_2885 9057732 51.95 µM -1.13319830029637 0.135909492061136 no 2968 0.128565493905345 4284 6471414
SGTC_2819 7996655 46.38 µM -1.1349044456466 0.135553970452273 no 2969 0.128207678521045 4185 6456960
SGTC_2663 amphotericin b 100 µM -1.13731136794102 0.135053507355476 no 2970 0.127704072074438 4243 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2483 5729050 27.16 µM -1.13963661203126 0.13457123210529 no 2971 0.127218862787107 4257 2865180
SGTC_2669 eugenol 100 µM -1.14020478128267 0.134453568944576 no 2972 0.127100498005489 4219 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_3312 9133330 71.43 µM -1.14072813831595 0.134345248537384 no 2973 0.126991536627131 4263 17617324
SGTC_1242 0402-0103 60.1 µM -1.14130687426781 0.134225536017913 no 2974 0.126871121239611 4165 432868
SGTC_712 r015-0009 80.6 µM -1.14145189864569 0.134195548961815 no 2975 0.12684095902809 4263 6813872 YLR060W FRS1
SGTC_661 1304-0007 33.6 µM -1.14417313060149 0.133633726152897 no 2976 0.126275921968548 4232 3117130
SGTC_1509 1326-1131 80 µM -1.14498755005156 0.13346589683372 no 2977 0.126107157354826 4195 768313
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.1450524131473 0.133452536579608 no 2978 0.126093723138399 4186 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2199 6590217 200 µM -1.14564878450925 0.133329741381835 no 2979 0.12597025155473 4129 703109
SGTC_127 0180-0333 59.125 µM -1.15007707373435 0.132420370955892 no 2980 0.125056064063294 4144 771601
SGTC_3300 9124615 50.48 µM -1.15202045616771 0.1320226406389 no 2981 0.124656333733388 4294 24824903
SGTC_3338 9144300 39.5675 µM -1.15370368392533 0.131678819692686 no 2982 0.124310836532082 4232 4901274
SGTC_2487 5918373 44.05 µM -1.15408612935067 0.131600786511092 no 2983 0.124232429728399 4309 2876279
SGTC_1898 st060199 18.6 µM -1.15572685624037 0.131266379006033 no 2984 0.123896449723576 4223 688866
SGTC_2689 tacrolimus 100 µM -1.15643698768189 0.131121824490919 no 2985 0.123751229866389 4270 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_76 0433-0009 400.328 µM -1.15759638691342 0.130886053319377 no 2986 0.123514392207103 4314 2841569
SGTC_303 1348-1668 34.2 µM -1.1582276684084 0.13075780149566 no 2987 0.123385570000165 4260 5380509
SGTC_933 2914-0560 114 µM -1.16058733558858 0.130279178330756 no 2988 0.122904879058082 4267 463887
SGTC_985 1493-0307 8.71 µM -1.16200079421424 0.129993060575215 no 2989 0.122617571162079 4263 3278274
SGTC_2582 agaric acid 100 µM -1.16297778789529 0.129795548149552 no 2990 0.122419257289786 3923 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_710 3448-4187 58 µM -1.16353854039417 0.129682278394359 no 2991 0.122305535352421 4228 3946412
SGTC_2665 lovastatin 100 µM -1.16761559174364 0.128860788799588 no 2992 0.121480929049113 4278 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2928 9011484 9.79 µM -1.16767275158273 0.128849297316094 no 2993 0.121469396002316 4263 2994751
SGTC_758 0868-0029 16 µM -1.17192921794181 0.127995568881688 no 2994 0.120612737657614 4270 762687
SGTC_1210 3013-0140 750 nM -1.17282529690353 0.12781634233151 no 2995 0.12043293573798 4281 905973
SGTC_1977 st070720 65.3 µM -1.17353123854566 0.127675268406665 no 2996 0.120291418656796 4297 682188
SGTC_11 0438-0307 1.3 µM -1.17420955061751 0.127539817919119 no 2997 0.120155550757169 4247 4011476
SGTC_2077 5212015 200 µM -1.17595094879917 0.127192539975322 no 2998 0.11980723885795 4139 780900
SGTC_3119 9125183 49.47 µM -1.17744703750955 0.126894708678017 no 2999 0.119508562462574 4084 22695334
SGTC_1560 lithocholic acid 53.1 µM -1.17891639227401 0.126602672273431 no 3000 0.119215734852973 4183 9903 A bile acid which acts as a detergent.
SGTC_651 3253-0966 34.4 µM -1.17895727194362 0.126594554077863 no 3001 0.119207595193839 4286 781462
SGTC_2442 5158906 48.48 µM -1.17945423730172 0.126495891914576 no 3002 0.119108674477266 4263 1893835
SGTC_234 nsc-17383 10.7 µM -1.18017980532336 0.126351941648793 no 3003 0.118964354600888 4285 408974
SGTC_1688 st021091 57.6 µM -1.18314759591221 0.125764330435222 no 3004 0.118375328729441 4292 3656366
SGTC_1138 3761-0006 1.03 µM -1.18473033962716 0.125451733800932 no 3005 0.118062041349063 4307 12061087
SGTC_1278 0874-0585 172 µM -1.18512113830481 0.125374633441238 no 3006 0.117984777242959 4340 766306
SGTC_146 3448-8650 53.125 µM -1.18516973809971 0.12536504753942 no 3007 0.117975171165924 4246 2891488 YIL048W NEO1
SGTC_930 2810-3379 265 µM -1.18935338332506 0.124541775639745 no 3008 0.117150318348164 4300 1015764
SGTC_764 1951-2361 146 µM -1.18996406977941 0.124421919541563 no 3009 0.117030257198938 4280 5438930
SGTC_1606 st000094 49.2 µM -1.19073480873866 0.124270765978742 no 3010 0.116878854173282 4304 1242210
SGTC_188 3229-0966 278.469 µM -1.19142287611537 0.124135934115827 no 3011 0.116743808392883 4319 5722370
SGTC_2850 9015429 58.44 µM -1.19177475936271 0.124067019574188 no 3012 0.116674787653194 4290 6457570
SGTC_2451 5856223 45.7 µM -1.19178726915716 0.124064570087519 no 3013 0.116672334430938 4250 2179896
SGTC_590 k048-0076 22.4 µM -1.1954632074393 0.123346266490772 no 3014 0.115953051493799 4303 6832814
SGTC_1810 st050138 53 µM -1.19867545790426 0.122720960522796 no 3015 0.115327082268364 4290 3444541
SGTC_2820 7989630 71.43 µM -1.20082678323101 0.122303422524172 no 3016 0.114909200083613 4324 2984098
SGTC_3011 9081274 71.4286 µM -1.20329326698535 0.121825945494335 no 3017 0.114431426826842 4285 6625322
SGTC_2287 7945887 168.79 µM -1.20406456685451 0.121676901695026 no 3018 0.114282311912827 4300 1245853
SGTC_3292 9120825 59.784 µM -1.20406923506054 0.121676000014416 no 3019 0.114281409832972 4284 24824900
SGTC_2625 euphol 100 µM -1.20852445634302 0.120817597892836 no 3020 0.11342279724862 4311 6708538 A triterpene alcohol.
SGTC_2998 9066762 71.4286 µM -1.21102949640875 0.120336819890993 no 3021 0.112942050111506 4348 4945196
SGTC_3186 9110464 49.47 µM -1.21196154984795 0.120158280675494 no 3022 0.112763549695161 4295 17018021
SGTC_3159 9100096 49.47 µM -1.21646432456153 0.119298382238111 no 3023 0.111904046598391 4232 25236875
SGTC_569 4130-2812 160 µM -1.21893831507964 0.118827775228385 no 3024 0.111433802904436 4141 743552
SGTC_2681 menadione 3.18 µM -1.22099953469605 0.118436688814609 no 3025 0.111043097983255 4322 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1465 k213-0056 144 µM -1.22236110173298 0.118178850789318 no 3026 0.110785551131186 4198 24048857 YMR208W ERG12
SGTC_2346 9031566 143.75 µM -1.22285285289757 0.118085826206106 no 3027 0.110692639356201 4275 4771086
SGTC_3315 9136395 68.55 µM -1.22378774285193 0.117909115892559 no 3028 0.110516154682901 4286 16876844
SGTC_3017 9080681 49.47 µM -1.22418505252257 0.117834074195189 no 3029 0.110441213309293 4326 16451914
SGTC_567 1080-0542 68.4 µM -1.22875957373722 0.116972497276238 no 3030 0.109580981362282 4187 5950415
SGTC_186 3455-3465 67.277 µM -1.2302249607287 0.116697449045976 no 3031 0.109306437636823 4322 755278
SGTC_1880 MG-132 525 µM -1.23100308815257 0.116551583675329 no 3032 0.109160854641896 4267 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2563 tomatine 8.54 µM -1.23174853416746 0.11641196597958 no 3033 0.109021516869653 4284 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1703 st026983 48.3 µM -1.23332417065366 0.116117248964219 no 3034 0.108727421771442 4340 1104023
SGTC_2164 5685496 200 µM -1.23449841990699 0.115897954621734 no 3035 0.10850861757635 4240 759046
SGTC_2516 gossypol 71.55 µM -1.23452632449007 0.115892746942047 no 3036 0.108503421821009 4330 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3213 9129884 49.47 µM -1.23730799364786 0.115374452796811 no 3037 0.107986380669641 4298 17190742
SGTC_3048 9093155 49.47 µM -1.2380075574684 0.115244366298654 no 3038 0.107856629294516 4286 25236002
SGTC_43 0570-0105 72.5 µM -1.23953700448528 0.114960323178722 no 3039 0.107573346787133 4304 1114046 YDL195W SEC31
SGTC_1304 1165-0502 251 µM -1.24011386908571 0.114853319488632 no 3040 0.10746663992218 4299 767425
SGTC_80 0159-0065 512.242 µM -1.24161831748508 0.114574589936349 no 3041 0.107188710060731 4245 1548079
SGTC_2635 hydroquinidine 100 µM -1.24378980475978 0.114173127368887 no 3042 0.106788466816128 4248 442912 An experimental heart treatment.
SGTC_2339 9000433 200 µM -1.24499610149023 0.113950541700086 no 3043 0.106566591633946 4331 2988954
SGTC_538 2922-0838 53.3 µM -1.24620702123522 0.113727414132965 no 3044 0.10634420102282 4329 777039
SGTC_3346 9158254 43.5805 µM -1.25181998044931 0.112697221554163 no 3045 0.105317733920131 4332 17639500
SGTC_2111 5486399 200 µM -1.25279585758132 0.112518792967423 no 3046 0.105140004796034 4274 689674
SGTC_1955 wogonin 32.4 µM -1.25370134595778 0.112353414773555 no 3047 0.104975289270544 4364 5281703 A flavanone.
SGTC_1666 st014829 29 µM -1.25772178053532 0.111621221139774 no 3048 0.104246196216602 4316 3858230
SGTC_104 0074-0074 590.992 µM -1.2582443819125 0.111526297303483 no 3049 0.104151694334999 4157 3943124
SGTC_2514 salinomycin 42.74 µM -1.25961178806094 0.11127819886146 no 3050 0.103904720486947 4386 23682228 A polyether potassium ionophore.
SGTC_1334 1486-0610 236 µM -1.26023635298668 0.111165011048529 no 3051 0.103792056205825 4393 3742339
SGTC_2856 9022925 19.48 µM -1.26877283725641 0.109626230004268 no 3052 0.102261047818596 4376 4944862
SGTC_3013 9080133 71.4286 µM -1.26905599333378 0.109575451845546 no 3053 0.102210547086763 4421 17050193
SGTC_2556 citropten 84.59 µM -1.2713627205856 0.109162417360374 no 3054 0.101799819280849 4360 2775 A potential DNA crosslinker.
SGTC_697 0508-1955 564 µM -1.27150545974386 0.109136895793053 no 3055 0.101774443174382 4337 6243113
SGTC_2308 7584454 197.62 µM -1.27344993894293 0.108789652542701 no 3056 0.101429213032378 4390 893577
SGTC_3187 9109394 49.47 µM -1.27714961939924 0.108131162283128 no 3057 0.10077471486036 4354 17098090
SGTC_2794 7785382 27.27 µM -1.27816159142192 0.107951546510932 no 3058 0.100596227859428 4344 2205081
SGTC_2492 derrusnin 100 µM -1.28154204439122 0.107353104848682 no 3059 0.100001670956731 4379 1715307 Part of coumarin class of compounds.
SGTC_452 diindolylmethane 8 µM -1.28451414785076 0.106828932118325 no 3060 0.0994810582638305 4347 3071 Inhibits expression of several cancer promoting factors.
SGTC_1652 st011932 78 µM -1.28683106003796 0.106421594469615 no 3061 0.099076589215619 4279 1551076
SGTC_910 3454-3003 490 µM -1.29944439663246 0.104223700146652 no 3062 0.0968957319412401 4265 820824
SGTC_2550 chrysin dimethyl ether 71.87 µM -1.29986807300258 0.104150449314524 no 3063 0.0968230946681631 4197 88881 An O-methylated flavonoid and antioxidant.
SGTC_1139 k015-0024 46.9 µM -1.29996682328928 0.10413338140999 no 3064 0.0968061701544209 4391 2766652
SGTC_570 0987-0065 62.6 µM -1.30087464745445 0.103976568955336 no 3065 0.0966506826835523 4204 3104428
SGTC_3325 9138760 55.175 µM -1.30091877597251 0.103968950809247 no 3066 0.0966431292549397 4305 43844959
SGTC_1975 st070967 30.8 µM -1.30252193259045 0.103692463566987 no 3067 0.0963690126855499 4346 261391
SGTC_2641 levomentholum 100 µM -1.30557206513885 0.103167898411662 no 3068 0.0958490626206759 4377 16666
SGTC_3104 9120930 49.47 µM -1.30575844925943 0.103135906456674 no 3069 0.0958173571166456 4389 17014836
SGTC_302 1094-0063 18.9 µM -1.30646510408851 0.103014677929784 no 3070 0.0956972192679707 4343 5440289
SGTC_1271 0832-2808 169 µM -1.31046724802935 0.10233005219895 no 3071 0.0950189084904753 4406 3663794
SGTC_2036 5160441 105 µM -1.31090863632337 0.102254749298859 no 3072 0.0949443163605182 4346 134534 YIL048W NEO1
SGTC_2529 gangaleoidin 93.61 µM -1.31135542454294 0.102178566203139 no 3073 0.0948688556166115 4385 4565183
SGTC_2769 toremifene 3.73 µM -1.31266642526183 0.101955262188477 no 3074 0.0946476879210894 4389 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2243 6634756 200 µM -1.3166093947518 0.101285793155726 no 3075 0.0939847940408348 4424 885676
SGTC_1058 3448-5425 97.3 µM -1.31676023806151 0.101260245526688 no 3076 0.093959502407859 4327 7279705
SGTC_3042 9091578 49.47 µM -1.31790934616212 0.101065780546273 no 3077 0.0937669983206477 4386 25236497
SGTC_2805 7950783 58.44 µM -1.3186620576715 0.100938545887088 no 3078 0.093641058406548 4379 1178958 YDL195W SEC31
SGTC_2502 avocadyne acetate 18.59 µM -1.31925132186762 0.100839021083199 no 3079 0.0935425528718799 4325 3952079
SGTC_2126 5251174 33.877 µM -1.31936903229088 0.100819148753266 no 3080 0.0935228847457242 4369 790722
SGTC_2270 7924575 90.91 µM -1.32223694084051 0.100335859347276 no 3081 0.0930446317979185 4355 1262135
SGTC_3288 9119690 36.221 µM -1.32266488710591 0.100263888629538 no 3082 0.0929734226777745 4370 17595618 YKL019W RAM2
SGTC_1118 chelidonine 707.474 nM -1.32384605150765 0.100065439488736 no 3083 0.0927770891267092 4365 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1716 st033144 30.6155 µM -1.32398697554993 0.100041781799539 no 3084 0.092753685171408 4389 674617
SGTC_130 0136-0219 337.655 µM -1.32552410425887 0.0997840007805401 no 3085 0.0924986900530538 4212 234244
SGTC_1956 st077085 54 µM -1.32935220471873 0.0991441266907724 no 3086 0.0918658992384988 4414 24208685
SGTC_1754 st042065 16.137 µM -1.33128064467071 0.0988229233027537 no 3087 0.091548342238059 4150 1126236 YIL048W NEO1
SGTC_749 1000-0129 128 µM -1.33414942806044 0.0983465050850166 no 3088 0.0910774447788039 4431 708470
SGTC_1847 st056231 15 µM -1.33471418506529 0.0982529145062291 no 3089 0.0909849545584799 4378 5393180
SGTC_334 1502-1024 68.5 µM -1.33645212218304 0.0979653157930818 no 3090 0.0907007698213127 4408 3296216
SGTC_3054 9094397 49.47 µM -1.33775053338638 0.0977508540320328 no 3091 0.0904888859841693 4385 2598354
SGTC_1611 st001856 99.4 µM -1.33858392672665 0.0976133818906342 no 3092 0.0903530807918011 4367 647478
SGTC_672 1441-0018 53.7 µM -1.33942904828688 0.09747411995448 no 3093 0.0902155190594551 4397 251141
SGTC_2983 9022671 12.99 µM -1.3414627805654 0.0971395921893255 no 3094 0.0898851230630492 4385 6405161
SGTC_899 1083-0020 478 µM -1.34389670495286 0.0967403455159925 no 3095 0.0894908958495568 4450 767123
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.34459449820405 0.0966261061874491 no 3096 0.0893781105258466 4350 676296 Flavone; oxidizing agent.
SGTC_586 0957-0265 8.15 µM -1.34704170198078 0.09622624502375 no 3097 0.0889834011147407 4272 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1753 st043925 64 µM -1.3484930666411 0.0959896744370226 no 3098 0.0887499243379394 4422 670181
SGTC_1079 idarubicin 2.36 µM -1.35000354075771 0.0957439235505421 no 3099 0.0885074235602561 4410 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3353 9151644 39.2805 µM -1.35365144773595 0.0951523263081607 no 3100 0.0879238024491269 4412 4909158
SGTC_2670 beta-carotene 100 µM -1.35403184260889 0.0950907913219777 no 3101 0.0878631094883311 4370 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2608 thymoquinone 42.66 µM -1.35574676189508 0.0948137394515356 no 3102 0.0875898777335772 4365 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_644 1498-1197 63.3 µM -1.35823177760533 0.0944133316160083 no 3103 0.0871950750895248 4428 6741615
SGTC_2751 anetholtrithion 17.25 µM -1.36696794591635 0.0930155794511454 no 3104 0.0858176764387405 4382 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_474 dl-dihydrosphingosine 5 µM -1.37130215475437 0.0923278266952006 no 3105 0.0851403921390684 4411 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2513 baicalein 25.65 µM -1.37226519359109 0.0921755238884957 no 3106 0.0849904484201636 4406 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_49 0717-0965 32.132 µM -1.37807273945196 0.0912610119672299 no 3107 0.0840904155930225 4482 5889349 YGL099W LSG1
SGTC_129 0088-0017 176.636 µM -1.37812613538515 0.0912526350554228 no 3108 0.0840821738073959 4271 182446
SGTC_824 1304-0008 100 µM -1.37911449086673 0.0910976818544403 no 3109 0.0839297283383956 4443 768245
SGTC_1661 st013063 9.66 µM -1.38255122081181 0.0905603944174129 no 3110 0.0834012573412994 4492 721395
SGTC_1587 estradiol valerate 56.1 µM -1.3834761609988 0.0904161947634623 no 3111 0.0832594559908863 4463 13791 A steroid.
SGTC_1038 k292-0204 154 µM -1.38410443602138 0.0903183429651631 no 3112 0.0831632394109555 4368 4454212
SGTC_2785 7756463 72.73 µM -1.3931315976518 0.0889210635153559 no 3113 0.0817899998223722 4406 2201551
SGTC_2994 9053520 71.4286 µM -1.3952234339365 0.0885995851419374 no 3114 0.0814742362545592 4456 4647384
SGTC_3145 9085516 49.47 µM -1.4055249925915 0.0870290383075756 no 3115 0.0799326114051777 4413 25236195
SGTC_980 1473-0395 201 µM -1.40812273608241 0.0866362964632503 no 3116 0.079547364859182 4339 768876
SGTC_3062 9077494 49.47 µM -1.41333808929401 0.0858518112301469 no 3117 0.0787781698422827 4395 16459633
SGTC_2104 5389443 200 µM -1.41392716991415 0.0857635378966511 no 3118 0.0786916437575499 4472 2244536
SGTC_1194 1488-0194 225 µM -1.42115812160919 0.0846855141787865 no 3119 0.0776353981421629 4416 1391452
SGTC_81 0411-0046 9.971 µM -1.42315103077886 0.0843901960189986 no 3120 0.0773461888671015 4435 12925265
SGTC_3307 9126885 69.2785 µM -1.42478894790593 0.0841480612399809 no 3121 0.0771091090215265 4424 24824909
SGTC_1596 piperlongumine 63 µM -1.42540100420963 0.084057714375709 no 3122 0.0770206589777722 4485 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_333 3486-0131 40.1 µM -1.42875557744492 0.0835638320965549 no 3123 0.0765372487783158 4474 6744690
SGTC_2987 9018338 71.43 µM -1.42947364922799 0.0834583967614935 no 3124 0.0764340716977715 4466 5055682
SGTC_1780 st038448 24.544 µM -1.42980817642475 0.0834093118871164 no 3125 0.0763860408683756 4480 728868 YDL195W SEC31
SGTC_93 0109-0045 59.227 µM -1.43345959014786 0.0828749534627169 no 3126 0.0758632696355847 4575 88733
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.4409165017254 0.0817916941618622 no 3127 0.074804136765114 4489 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1246 0422-0085 105 µM -1.44100872304228 0.0817783643813156 no 3128 0.074791109217686 4462 264295
SGTC_2313 7726885 200 µM -1.44175245088647 0.0816709249053457 no 3129 0.0746861105500933 4477 726423
SGTC_1591 genipin 88.4 µM -1.4427789964646 0.0815228042250383 no 3130 0.0745413688258086 4475 442424 A DNA cross-linking agent.
SGTC_3162 9099653 49.47 µM -1.44314580243479 0.08146992679572 no 3131 0.0744897015692003 4444 25237511
SGTC_2358 9037157 4 µM -1.44356368818475 0.0814097174134473 no 3132 0.0744308726778345 4460 2388925
SGTC_427 1354-0053 47.3 µM -1.44797561477201 0.0807760890234676 no 3133 0.0738119352700025 4488 6813657
SGTC_2333 9017922 200 µM -1.45573995802048 0.0796700497513597 no 3134 0.0727322596887314 4481 3163164
SGTC_1093 fluphenazine 7.97 µM -1.46043107176463 0.0790073702091214 no 3135 0.0720858192143888 4506 6602611 An atypical antipsychotic.
SGTC_2736 butenafine 14.65 µM -1.46222045427586 0.0787557000265343 no 3136 0.0718404041299968 4417 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_505 gw-5074 63.9 µM -1.46472822392018 0.0784040141329297 no 3137 0.0714975406863023 4493 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_647 0140-0236 81 µM -1.46582001248168 0.0782512758887459 no 3138 0.0713486637676021 4489 990837
SGTC_2363 9053361 176 µM -1.46925161223135 0.0777726736380259 no 3139 0.0708822779700623 4515 6469797 YMR079W SEC14
SGTC_2649 anisomycin 9.56 µM -1.4694591053908 0.0777438061386307 no 3140 0.0708541530151814 4529 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_995 3931-2021 34.6 µM -1.47091417163405 0.0775415984117072 no 3141 0.0706571648011301 4489 730143
SGTC_190 3970-0790 3.722 µM -1.47747066737354 0.0766354062503688 no 3142 0.0697747577343129 4450 2832352
SGTC_1945 st075991 56.6 µM -1.48028471898863 0.0762489474528366 no 3143 0.0693986397724524 4472 1084980
SGTC_264 promethazine 12.5 mM -1.48978457137853 0.074955266453827 no 3144 0.0681404445751366 4363 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_282 k297-0036 65.7 µM -1.49006730049491 0.074917022819413 no 3145 0.0681032705199455 4488 5061378
SGTC_1452 4194-0072 190 µM -1.49183503603634 0.074678245707977 no 3146 0.0678711983073734 4537 1343545
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.49851932723543 0.0737806119490181 no 3147 0.0669991874978454 4500 61125 An anti-inflammatory.
SGTC_904 1141-0088 396 µM -1.49940452617547 0.0736623595451956 no 3148 0.0668843600567333 4499 1378119
SGTC_411 enrofloxacin 100 µM -1.50200441146077 0.0733158824503273 no 3149 0.066547984767105 4530 71188 A bacterial gyrase inhibitor.
SGTC_2085 5307070 144.047 µM -1.507039329193 0.0726484441739488 no 3150 0.0659002882569154 4442 2840351
SGTC_2073 5212005 126 µM -1.50828046790242 0.0724846335759463 no 3151 0.0657413800191075 4408 691789
SGTC_562 3772-2733 112 µM -1.50847341350271 0.0724591932542076 no 3152 0.0657167030778185 4488 2876874 YIL048W NEO1
SGTC_1179 1021-1431 9.29 µM -1.51186556762696 0.072013046402783 no 3153 0.0652840325342166 4521 2840958
SGTC_3274 9138298 49.47 µM -1.51249361761054 0.0719306748413646 no 3154 0.0652041675363311 4478 17015756
SGTC_2457 5731572 11.68 µM -1.51816546532833 0.0711900558463695 no 3155 0.0644863455456788 4554 2865357
SGTC_1295 1013-0063 9.78 µM -1.51855724364501 0.0711391151700364 no 3156 0.0644369901529581 4513 6826038
SGTC_871 0574-0004 149 µM -1.52114732848629 0.070803045278854 no 3157 0.0641114348793469 4469 9551173
SGTC_2817 7995342 71.43 µM -1.52198204679593 0.0706949988220735 no 3158 0.0640067896072277 4486 18879975
SGTC_2771 fluoxetine 41.05 µM -1.52439540417018 0.0703833250482807 no 3159 0.063704983736414 4492 3386 A selective serotonin reuptake inhibitor.
SGTC_328 k915-0120 63.5 µM -1.52719509946061 0.0700230825008022 no 3160 0.0633562522693478 4515 6624543
SGTC_1150 3909-7983 10.9 µM -1.52768494947916 0.0699601985648008 no 3161 0.0632953893430593 4512 23965914
SGTC_2197 6588183 93.1375 µM -1.53525748564247 0.0689936020497961 no 3162 0.0623602963756301 4527 884136
SGTC_751 0833-0568 350 µM -1.53748212460432 0.06871160306049 no 3163 0.0620876445614095 4518 6954252
SGTC_1573 oleylamine 1.06 µM -1.5411368028301 0.0682502604743237 no 3164 0.0616417472205916 4507 5356789 An amine of the fatty acid oleic acid.
SGTC_110 0850-0284 111.64 µM -1.54243110720646 0.0680874504451215 no 3165 0.061484433607327 4429 3906265
SGTC_2916 7875993 68.79 µM -1.54275696215354 0.0680465085633274 no 3166 0.0614448776769331 4419 1299250
SGTC_1499 4480-0877 67.3 µM -1.55028253199483 0.0671062411777319 no 3167 0.0605368590432814 4511 2861909
SGTC_357 1325-0123 420 µM -1.55039058041267 0.0670928148203166 no 3168 0.0605238990238702 4515 1098503
SGTC_2261 9010538 184.68 µM -1.55348015907615 0.0667097746424623 no 3169 0.0601542328606457 4498 6457250
SGTC_1813 st051246 8.6015 µM -1.55528845195274 0.0664863722528955 no 3170 0.0599386932087312 4477 5291959
SGTC_3021 9087658 49.47 µM -1.55578403919589 0.0664252470215888 no 3171 0.0598797273633242 4534 25237042
SGTC_1 0258-0098 57.368 µM -1.55892415485585 0.0660389590451187 no 3172 0.0595071662551181 4441 6790032 YDR047W HEM12
SGTC_539 4859-0462 2.54 µM -1.57054651073004 0.0646243380014226 no 3173 0.0581440113971499 4558 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2969 9091408 28.7 µM -1.57479101044425 0.064113623967635 no 3174 0.057652346050015 4466 4286311
SGTC_741 4582-0002 126 µM -1.57661177241606 0.0638955071125658 no 3175 0.057442441145517 4551 2912688
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.57819817910537 0.0637059355186531 no 3176 0.0572600442261743 4512 756377
SGTC_2866 9034245 58.44 µM -1.5859859904612 0.0627816514389946 no 3177 0.0563712437923383 4535 6462273
SGTC_1216 1165-0504 9.65 µM -1.587699886492 0.0625796502199099 no 3178 0.0561771093665759 4561 6304004
SGTC_1512 0259-0544 12.2 µM -1.5926385328947 0.0620004100261815 no 3179 0.0556206520168123 4511 18476
SGTC_321 4534-3890 65.3 µM -1.59407390609293 0.061832846129558 no 3180 0.0554597412865761 4547 699746
SGTC_2074 5212007 75.395 µM -1.59419623694848 0.0618185817219441 no 3181 0.0554460445519024 4473 758611
SGTC_2666 tannic acid 100 µM -1.59805813172769 0.0613695840978704 no 3182 0.055015020173166 4512 16134267 A thiamine antagonist.
SGTC_1799 st045822 46.1415 µM -1.61168087389814 0.059806074505583 no 3183 0.0535157008748896 4534 3674992
SGTC_1166 k206-0078 225 µM -1.61215970284449 0.0597516913740099 no 3184 0.0534635958494379 4565 5404595
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.61481939645673 0.0594503209029608 no 3185 0.0531749057225005 4520 1241132 A phosphatase inhibitor.
SGTC_2057 5236571 38.335 µM -1.61551515663011 0.0593716811073424 no 3186 0.0530995903807234 4490 54684039 YBR257W POP4
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.61723778365667 0.0591773283840191 no 3187 0.052913481670749 4503 6708630 An antioxidant.
SGTC_1647 st011722 22.4 µM -1.61780025491213 0.0591139766076817 no 3188 0.0528528257270495 4543 2854783
SGTC_1432 4049-0298 68.4 µM -1.62145392436225 0.0587037538385011 no 3189 0.0524601619622835 4584 741646
SGTC_646 4092-0839 27.3 µM -1.62235608225885 0.0586028071042663 no 3190 0.0523635634675508 4575 877796
SGTC_1751 st044839 27.194 µM -1.62239993117653 0.0585979041154934 no 3191 0.0523588719490471 4589 5291326
SGTC_3112 9123419 49.47 µM -1.62969552845998 0.0577866179507521 no 3192 0.0515829314534407 4601 17015854
SGTC_2121 5257820 149.641 µM -1.6349988764877 0.057202436954917 no 3193 0.0510246415731545 4583 791256
SGTC_2748 diazoxide 86.69 µM -1.63773997023025 0.0569023239603952 no 3194 0.0507379744069865 4641 3019 A potassium channel activatior.
SGTC_738 1315-0003 72.4 µM -1.63877764161811 0.0567890369257184 no 3195 0.0506297886181325 4569 6251474
SGTC_156 3474-0145 5.642 µM -1.64016024591047 0.0566383682104931 no 3196 0.0504859263226735 4491 2265471
SGTC_650 1328-0195 38 µM -1.64558709245345 0.0560500219616825 no 3197 0.0499243991857617 4576 2780821
SGTC_2099 5377090 177.372 µM -1.65237733035363 0.0553206657268798 no 3198 0.0492288269556212 4554 2243829
SGTC_1843 st055809 45.5 µM -1.65326457585879 0.0552259206811056 no 3199 0.0491385145622572 4594 16413835
SGTC_3324 9138759 60.749 µM -1.66419806108328 0.0540688739560991 no 3200 0.0480364277156007 4579 45595710
SGTC_821 1114-0266 29.2 µM -1.66529815038088 0.0539535263044997 no 3201 0.0479266436865617 4590 3123235
SGTC_65 0798-0905 34.986 µM -1.66600450072828 0.0538795661185811 no 3202 0.047856259001927 4549 3602145
SGTC_2495 cafestol 54.53 µM -1.6770016860754 0.0527384016916194 no 3203 0.0467710760703232 4579 16667697 An anti-infammatory.
SGTC_968 1309-0633 340 µM -1.67937476512487 0.0524946838123201 no 3204 0.0465395140832003 4601 3761976
SGTC_2791 5663188 71.43 µM -1.6856150981721 0.0518580599528729 no 3205 0.0459349796240853 4581 54690634
SGTC_1659 st012954 42.1 µM -1.68586553492294 0.0518326396201632 no 3206 0.0459108507875683 4567 24207262
SGTC_1279 0874-0590 65.2 µM -1.68727363841676 0.0516898958058723 no 3207 0.0457753737485811 4651 3523074
SGTC_892 0929-0076 29 µM -1.69760252653599 0.0506523557176519 no 3208 0.0447914028294046 4572 5751038
SGTC_112 phenothiazine 287.218 µM -1.69963357851087 0.0504503007659537 no 3209 0.0445999350963352 4551 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2767 sibutramine 71.45 µM -1.70374734843282 0.0500430188674317 no 3210 0.0442141491278762 4576 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_557 1315-0110 16.2 µM -1.70385138190546 0.0500327531705004 no 3211 0.0442044279379729 4568 6833801
SGTC_1987 st072290 61.9 µM -1.70817218292657 0.0496078712018427 no 3212 0.0438021991956044 4609 54697379
SGTC_2461 5755302 26.15 µM -1.71012882777841 0.0494164158711364 no 3213 0.0436210265312228 4584 2788904
SGTC_744 1594-0068 283 µM -1.71216675020897 0.049217635209801 no 3214 0.0434329715122636 4583 668392
SGTC_1267 0828-0272 9.49 µM -1.71407075231853 0.0490324947259602 no 3215 0.0432578662740509 4639 745334
SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.71436798784202 0.0490036425447806 no 3216 0.0432305819512065 4595 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1361 1608-0041 5.61 µM -1.72416560437398 0.0480601720670764 no 3217 0.04233897575087 4604 X1361
SGTC_426 0988-0037 14.6 µM -1.73020709361095 0.0474856842851294 no 3218 0.0417966407118121 4598 5383008
SGTC_2030 5175110 200 µM -1.74299950425787 0.0462874076576327 no 3219 0.0406668507065841 4607 2831986
SGTC_1435 4092-0789 56.7 µM -1.74707670635859 0.0459106358509914 no 3220 0.040312016675738 4627 2248285
SGTC_2139 5578692 56.4705 µM -1.74852595804327 0.0457773065037926 no 3221 0.0401864973770866 4591 650991 YMR113W FOL3
SGTC_3201 9113999 49.47 µM -1.75094511365158 0.0455554406598273 no 3222 0.0399776823999791 4579 16649224
SGTC_1031 k035-0009 16 µM -1.75206239156747 0.0454532650298737 no 3223 0.0398815400937518 4632 5180959
SGTC_3281 9140613 49.47 µM -1.75277116812051 0.0453885426527477 no 3224 0.0398206470134726 4598 16013766
SGTC_2875 9039966 71.43 µM -1.75498544676925 0.0451868217951933 no 3225 0.0396308985544371 4602 6463691
SGTC_1219 1469-0211 33.1 µM -1.7594440268417 0.0447828337094277 no 3226 0.0392510597342294 4621 6822282
SGTC_134 0269-0018 6.916 µM -1.76459645711814 0.0443196043021866 no 3227 0.0388158056731623 4563 4378915
SGTC_2180 6301957 200 µM -1.76490256234194 0.0442922058825377 no 3228 0.0387900714957072 4634 845462
SGTC_1059 3448-6867 171 µM -1.78081820587575 0.0428863566548262 no 3229 0.0374710771198407 4584 3934407
SGTC_2869 9037858 32.47 µM -1.79411864930251 0.0417393668935605 no 3230 0.0363971164971579 4585 27187042
SGTC_1243 0416-0003 5.65 µM -1.80682224011808 0.040667169162292 no 3231 0.0353949999364139 4607 2141977
SGTC_1875 nocodazole 6 µM -1.81449874031724 0.0400301717186617 no 3232 0.0348004882491539 4652 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_628 1636-0253 16 µM -1.81651974608718 0.0398638233749073 no 3233 0.0346453408660504 4628 4456143
SGTC_634 1611-4317 11.2 µM -1.82314267198771 0.0393226264836002 no 3234 0.0341408925405472 4657 2843522
SGTC_382 3229-0966 23.2 µM -1.823772063336 0.0392715079160552 no 3235 0.0340932695157789 4657 5722370
SGTC_2375 9072683 200 µM -1.8263205895441 0.0390650715904315 no 3236 0.0339009927996675 4658 16798029
SGTC_1654 st012436 41.8 µM -1.8443895968468 0.037626652893557 no 3237 0.0325631911664186 4658 4323132
SGTC_2874 9043904 71.43 µM -1.84562428529816 0.0375299625768587 no 3238 0.032473388895436 4565 4463428
SGTC_2707 st078556 66.6 µM -1.85139476136047 0.0370807544162201 no 3239 0.0320563910921689 4571 17250899
SGTC_2591 skatole 100 µM -1.85203164611325 0.0370314459227234 no 3240 0.0320106393747263 4616 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1972 st070201 17.4 µM -1.85340616035124 0.0369252117805652 no 3241 0.0319120825130703 4654 2829099
SGTC_512 prima-1 270 µM -1.8546804004693 0.0368269503563236 no 3242 0.0318209396059193 4645 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2379 9035213 200 µM -1.85870099151291 0.0365183084067475 no 3243 0.0315347664289482 4639 646551
SGTC_495 decylubiquinone 155 µM -1.86740035702982 0.0358577405399261 no 3244 0.0309228499971521 4647 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2079 5212404 121 µM -1.8710433761224 0.0355840392167361 no 3245 0.0306695345115463 4609 758462
SGTC_2360 9040895 200 µM -1.87951270541997 0.0349543506491801 no 3246 0.0300872601651888 4665 4914414
SGTC_3154 9100113 49.47 µM -1.88190867826458 0.0347778808209582 no 3247 0.0299242079731711 4622 25237525
SGTC_2096 5468907 200 µM -1.88507229419563 0.0345459933134279 no 3248 0.0297100390085756 4668 759785
SGTC_3259 9138485 49.47 µM -1.89897276493085 0.0335421165718325 no 3249 0.0287840284896303 4622 17646153
SGTC_1159 4092-0538 61.2 µM -1.90958301510914 0.0327921213568774 no 3250 0.0280934618652044 4683 717301
SGTC_1928 4'-methoxychalcone 40.3 µM -1.92339787716353 0.0318363789702169 no 3251 0.0272150503684558 4652 641818
SGTC_316 k060-0003 58.6 µM -1.92574663902644 0.0316761978685601 no 3252 0.0270680086270711 4696 6152314
SGTC_2588 indole-3-carbinol 100 µM -1.92938175231993 0.0314296034226845 no 3253 0.0268417436777893 4636 3712 Induces cell cycle arrest.
SGTC_394 menadione 8.33 µM -1.94578017303359 0.0303368366010339 no 3254 0.025840575631577 4665 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2367 9070478 135.38 µM -1.94716887694333 0.0302457594540256 no 3255 0.0257572458252046 4611 572802
SGTC_1994 st072947 40.9 µM -1.95571517390879 0.0296902328802068 no 3256 0.0252493581110218 4692 5286565 YDL195W SEC31
SGTC_289 k017-0060 526 µM -1.96541382193229 0.0290700844197743 no 3257 0.0246831805092476 4677 5512909
SGTC_1456 k015-0012 13 µM -1.96840308521785 0.0288811296207187 no 3258 0.0245108386004105 4667 2989616
SGTC_1323 1348-1351 11.2 µM -1.96926079914668 0.028827101405111 no 3259 0.0244615751431435 4668 6989654
SGTC_2255 7941087 197.44 µM -1.97179719979771 0.0286678225329727 no 3260 0.0243163810734513 4716 935561
SGTC_2100 5377183 190 µM -1.97270888698358 0.0286107502317979 no 3261 0.0242643694372537 4695 2844202
SGTC_3224 9130643 49.47 µM -1.97424179563779 0.0285150020412547 no 3262 0.0241771278112346 4657 17644395
SGTC_1570 verbenone 133 µM -1.97843746352582 0.0282542956397159 no 3263 0.0239396884548726 4670 29025 A natural terpanoid with antifungal properties.
SGTC_626 0214-0009 33 µM -1.98033515677217 0.0281370318686002 no 3264 0.0238329404279332 4698 3437874
SGTC_2643 anethole 100 µM -1.99128363565456 0.0274683810956031 no 3265 0.0232248567507148 4686 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1329 1447-1697 50.6 µM -2.00115849333449 0.026876713318253 no 3266 0.0226876561930294 4681 2840515
SGTC_3153 9100258 49.47 µM -2.00654428672233 0.0265585241439915 no 3267 0.0223991043332831 4615 25236848
SGTC_2349 9023730 187.07 µM -2.01076199085464 0.0263115477079134 no 3268 0.0221753013301402 4689 4126287
SGTC_341 1486-1430 230 µM -2.0207117408744 0.0257365178848885 no 3269 0.0216548068661528 4663 2054753 YPL210C SRP72
SGTC_492 tmb-8 126 µM -2.021739950888 0.0256776983978619 no 3270 0.0216016121345611 4723 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_3126 9127922 49.47 µM -2.02619751064417 0.0254240003566849 no 3271 0.0213722743234613 4635 45595682
SGTC_1967 st070177 51.4 µM -2.04659296753385 0.0242898372211351 no 3272 0.0203490329584208 4703 5729214
SGTC_46 0329-0187a 2.197 µM -2.04667296587435 0.0242854736786383 no 3273 0.0203451026649086 4672 46494817
SGTC_1627 st003713 25.6 µM -2.05457730882991 0.0238575620151705 no 3274 0.0199599246083046 4679 16195070 YER133W GLC7
SGTC_1959 st077091 55.8 µM -2.05819748182509 0.0236637056362952 no 3275 0.0197855901266206 4681 821356 YKL052C ASK1
SGTC_786 4544-0069 423 µM -2.07095215029226 0.0229912301150381 no 3276 0.0191816339541836 4679 748821 YLR208W SEC13
SGTC_2652 actinonin 100 µM -2.07228645470475 0.0229218196994058 no 3277 0.0191193674368127 4741 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_595 3909-8003 73.7 µM -2.0732434276043 0.0228721468153944 no 3278 0.0190748153312876 4732 699517
SGTC_2294 7971431 200 µM -2.07542470814661 0.0227592635628249 no 3279 0.0189735951054369 4683 5741572
SGTC_1937 st074714 47.2 µM -2.08651722484778 0.0221924549981597 no 3280 0.0184658982905126 4664 17250970
SGTC_384 k007-0144 5.16 µM -2.08906395685217 0.0220640162635206 no 3281 0.0183509831613955 4686 6824886
SGTC_3246 9135460 32.98 µM -2.11414273205623 0.0208324031620813 no 3282 0.0172515391900626 4722 41446951
SGTC_2125 5246583 200 µM -2.11863068132473 0.0206182568643059 no 3283 0.0170608453550713 4694 835267
SGTC_1241 0364-0022 50.8 µM -2.1224549378874 0.0204372534207315 no 3284 0.0168997764816771 4704 4563895
SGTC_1384 3089-0840 101 µM -2.12349370940412 0.0203883211788908 no 3285 0.0168562510373106 4699 1069836
SGTC_369 0957-0393 4.5 µM -2.12888246008502 0.02013607011771 no 3286 0.0166319931453153 4700 6997992
SGTC_3131 9127911 49.47 µM -2.13201671148676 0.0199905747418219 no 3287 0.0165027363827354 4684 45595681
SGTC_1483 3453-0561 55.9 µM -2.1449109008135 0.0194013589010985 no 3288 0.0159799857532021 4741 4546991
SGTC_1641 st009299 47.1 µM -2.15019161016481 0.0191643446050613 no 3289 0.0157700307618978 4695 4046054
SGTC_1948 st076329 66.6 µM -2.15379268440413 0.0190041328286759 no 3290 0.0156282168373903 4669 24208413
SGTC_1413 3910-0535 34.4 µM -2.17919766846465 0.0179059126041259 no 3291 0.0146584935356582 4736 2876951
SGTC_621 3584-0052 32.1 µM -2.18226166807608 0.0177771921136445 no 3292 0.0145451131515286 4744 2273927
SGTC_1911 st060208 74.3 µM -2.1956059997906 0.0172257553249716 no 3293 0.0140600782182586 4721 688783
SGTC_354 2783-3500 4.88 µM -2.20681475034835 0.016773925672206 no 3294 0.0136635020633085 4711 6740761
SGTC_288 1315-0019 35.1 µM -2.20792636614919 0.0167296735596472 no 3295 0.0136247032683749 4733 6811474
SGTC_1883 5-benzylidenerhodanine 20 µM -2.22741012930947 0.0159701137422363 no 3296 0.0129599380330306 4727 1273210
SGTC_465 cgp-37157 41 µM -2.22946383362731 0.0158918013278482 no 3297 0.012891529545791 4772 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -2.23356107082804 0.015736547703072 no 3298 0.0127559838922201 4719 2374 Ca(2+)-ATPase inhibitor.
SGTC_1002 4049-0206 172 µM -2.25886406150823 0.0148063001801342 no 3299 0.0119459210637138 4716 4662749
SGTC_25 0118-0223 35.662 µM -2.26804488157589 0.0144806680171532 no 3300 0.0116632356444654 4724 5333628
SGTC_493 zm226600 134 µM -2.28335557293086 0.0139513259780136 no 3301 0.011204715986841 4733 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2695 st077686 51.995 µM -2.28917845067615 0.0137544336347953 no 3302 0.0110344930637514 4707 2876092
SGTC_891 0929-0073 133 µM -2.2961471745996 0.0135219511199499 no 3303 0.0108337338800552 4746 5603632
SGTC_1130 3454-2858 15.9 µM -2.30627664732276 0.0131900752255164 no 3304 0.0105475895750242 4704 715628 YIL048W NEO1
SGTC_1882 5615643 20 µM -2.30720216175874 0.0131601061421614 no 3305 0.0105217763228373 4745 2253075
SGTC_443 clozapine 122 µM -2.31272729588293 0.0129824181034514 no 3306 0.0103688186462219 4741 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2724 maprotiline 69.64 µM -2.32693787146183 0.0125349056494283 no 3307 0.0099842860921926 4703 4011 A tricyclic antidepressant.
SGTC_1981 st071826 47 µM -2.32802250183838 0.0125013042705479 no 3308 0.00995545442856148 4752 11838600
SGTC_604 1000-0114 314 µM -2.34200012085533 0.012075213424795 no 3309 0.00959035435653219 4763 1572745
SGTC_2621 lithochol-11-enic acid 100 µM -2.34232241781686 0.0120655389546562 no 3310 0.00958207574602032 4703 6708711
SGTC_882 0843-0131 351 µM -2.34293271450884 0.0120472379329158 no 3311 0.00956641660560198 4756 5425421
SGTC_907 3448-6986 75.5 µM -2.34374243257319 0.0120229939985378 no 3312 0.00954567519495869 4736 590582
SGTC_532 1548-0774 215 µM -2.38533607608172 0.0108332216460353 no 3313 0.00853176253256206 4761 5932993
SGTC_117 lucigenin 22.078 µM -2.38596977331708 0.010815917405854 no 3314 0.00851707553033587 4710 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_784 4579-0127 173 µM -2.39748887723304 0.0105055352531392 no 3315 0.00825394107787801 4750 1948547
SGTC_1590 st077108 57.8 µM -2.41027948172973 0.0101700130042903 no 3316 0.0079701521860165 4760 5489485
SGTC_436 n,n-dimethylsphingosine 3.3 µM -2.4149102514411 0.0100508646241934 no 3317 0.00786954364483198 4741 5282309
SGTC_2606 farnesol 9.78 µM -2.44995931070935 0.00918790574053008 no 3318 0.00714361794338391 4736 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1540 guanosine 70.6 µM -2.45764501539766 0.00900758475599929 no 3319 0.00699256677457636 4743 6802 Guanosine is a purine nucleoside
SGTC_497 capsazepine 133 µM -2.45893968832881 0.00897751632815873 no 3320 0.00696740126083805 4724 2733484 A calcium channel blocker.
SGTC_468 gf-109203x 121 µM -2.46333645911356 0.00887605785666545 no 3321 0.0068825337903303 4784 2396 A protein kinase C inhibitor.
SGTC_3142 9086498 49.47 µM -2.48410044293587 0.00841037396293106 no 3322 0.00649395841877031 4661 25236367
SGTC_1913 st060213 96.1 µM -2.48574825691273 0.00837435324658916 no 3323 0.00646396906735533 4735 688959
SGTC_3297 9117502 71.43 µM -2.50353722629849 0.00799403260269926 no 3324 0.00614793722439952 4763 7453720
SGTC_1116 jasmonic acid 1.58368 µM -2.5180871898104 0.00769433633464282 no 3325 0.00589970540972292 4784 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2593 nobiletin 86.24 µM -2.51875240572573 0.00768087399305527 no 3326 0.00588857195962546 4739 72344 An anti-infammatory.
SGTC_29 0299-0004 12.984 µM -2.54414225167053 0.00718230366371045 no 3327 0.00547732309491094 4727 16871 A napthoquinone isolated from Swertia calycina.
SGTC_917 harmaline 728.087 nM -2.54966482514554 0.00707771713402974 no 3328 0.00539132640018456 4715 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_885 0865-0106 16.8 µM -2.55904261002683 0.00690319664679236 no 3329 0.00524804377004356 4755 2793380
SGTC_3265 9137266 49.47 µM -2.57274881094143 0.00665496044724331 no 3330 0.00504472024991186 4755 17224265
SGTC_1554 st069299 38.7 µM -2.61629920139304 0.00591777740254999 no 3331 0.00444443145608096 4758 24207999
SGTC_2247 cerulenin 830 nM -2.61754353756637 0.00589782291360461 no 3332 0.00442825946840581 4772 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2696 st077691 74.316 µM -2.62043493512828 0.00585168600065352 no 3333 0.00439088430337062 4761 757133
SGTC_2876 9059903 25.97 µM -2.62974035592029 0.00570536874688681 no 3334 0.00427250516174695 4772 6916095
SGTC_270 tamoxifen 5.46 µM -2.68150224842613 0.00494923189721513 no 3335 0.00366462109527832 4765 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1335 1486-0900 202 µM -2.68761732662835 0.0048660774864385 no 3336 0.00359819079061912 4777 X1335
SGTC_276 colchicine 750 µM -2.73456353377255 0.00426807616365128 no 3337 0.00312315198628279 4792 2833 A microtubule depolymerizer.
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -2.73561523977637 0.00425546711032064 no 3338 0.00311318903163648 4740 6708760
SGTC_1060 3448-7350 82 µM -2.77621347226031 0.00379348615454042 no 3339 0.00274980429734105 4769 570178
SGTC_2387 9077560 195.08 µM -2.78621658805122 0.00368679624908433 no 3340 0.00266636136712768 4777 5303272
SGTC_478 N-arachidonylglycine 10 µM -2.81912992484966 0.00335449148568254 no 3341 0.00240770112865898 4800 5283389
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -2.82416734532476 0.00330607939841738 no 3342 0.00237018136829978 4791 5393153
SGTC_3133 9127736 49.47 µM -2.83165492607492 0.0032352805521612 no 3343 0.00231538970005006 4774 27243420
SGTC_1113 artemisinin 1.17947 µM -2.86305972272467 0.00295295783002245 no 3344 0.00209785735278241 4788 2240 An anti-malaria and mitochondrial poison.
SGTC_1393 3470-5649 58.2 µM -3.0380193521078 0.00174872859607307 no 3345 0.00119069330552987 4792 4108395
SGTC_2870 9038528 12.99 µM -3.09192495352148 0.00148030492076437 no 3346 0.000994315586226175 4792 6463316
SGTC_3293 9120939 62.045 µM -3.17921782786958 0.00112430113805274 no 3347 0.000738365352040191 4786 934087
SGTC_1717 st033143 58.0435 µM -3.23397890074831 0.000942973219126461 yes 3348 0.00061039237026696 4776 674616
SGTC_770 0389-1121 67.2 µM -3.25351200428284 0.000885085123034966 yes 3349 0.000569939545435552 4799 6753108
SGTC_389 tpck 16.7 µM -3.26405252721188 0.000855222143111903 yes 3350 0.000549154006424584 4797 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_180 1486-1293 102.781 µM -3.66974752941314 0.000212296242383269 yes 3351 0.000121395070365327 4798 4140536
SGTC_278 4092-0821 23.9 µM -3.74413869906802 0.00016192262614059 yes 3352 9.05068224685104e-05 4786 877900
SGTC_2292 7671323 168.05 µM -4.08753026388127 4.35840066073406e-05 yes 3353 2.17994907567481e-05 4806 937504
SGTC_2297 7971671 152.32 µM -4.34629095936518 1.51492657616645e-05 yes 3354 6.9229439911959e-06 4806 909016
SGTC_2354 9060492 162 µM -4.37905687365076 1.3196752716089e-05 yes 3355 5.95970124553532e-06 4793 6471895
SGTC_176 1486-1328 72.834 µM -10.9558663503647 4.73972516779106e-26 yes 3356 3.11397759580897e-28 4810 22310231