SGTCid condition conc unit RNT1|YMR239C.score RNT1|YMR239C.strain.pval RNT1|YMR239C.strain.significant RNT1|YMR239C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2291 7917025 104.35 µM 5.54486774088556 6.46481433326853e-09 yes 1 1.47088223581145e-08 3 2964612
SGTC_873 0591-4978 488 µM 4.73068506446445 6.16060727526899e-07 yes 2 1.11881715934052e-06 3 3305145
SGTC_787 4152-0075 138 µM 4.47743869120986 2.21427176004919e-06 yes 3 3.77719561503946e-06 2 9566539
SGTC_876 0720-0963 56.8 µM 4.12359761984935 1.18621946989665e-05 yes 4 1.86500134590253e-05 4 765861
SGTC_752 1896-0090 130 µM 4.07536578537581 1.47660049123603e-05 yes 5 2.29710369435961e-05 3 772567
SGTC_545 4218-0007 221 µM 4.02404480701881 1.85922348247964e-05 yes 6 2.86035128587752e-05 7 2840508
SGTC_1620 st003704 16.5 µM 3.90827731087379 3.09617903021829e-05 yes 7 4.64782867291856e-05 4 2834414
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 3.88496657686204 3.42544279399808e-05 yes 8 5.11719835521323e-05 14 16725076
SGTC_523 1934-0222 13.7 µM 3.84300831661913 4.10317109703666e-05 yes 9 6.0767674328841e-05 5 1361595
SGTC_777 1315-0167 517 µM 3.63586243816271 9.74852295762636e-05 yes 10 0.000138526078389733 5 4221767
SGTC_3295 9122362 53.5725 µM 3.52291444129462 0.000153459535537155 yes 11 0.000213414562915013 8 4730473
SGTC_2813 7971799 71.43 µM 3.48849204203678 0.000175771570639697 yes 12 0.000242876640441595 13 2234054
SGTC_341 1486-1430 230 µM 3.43940850346856 0.000212875468677839 yes 13 0.000291493405955231 30 2054753 YPL210C SRP72
SGTC_511 blebbistatin 171 µM 3.41382957713863 0.000234994898969588 yes 14 0.00032028315405339 9 3476986 A myosin inhibitor.
SGTC_1170 0310-0127 64.8 µM 3.37513801690383 0.000272560253008623 yes 15 0.000368893400304129 18 774975
SGTC_1952 st077036 64.1 µM 3.34347713526082 0.000307384934799176 yes 16 0.000413677558495964 17 2937007
SGTC_449 xestospongin c 11.1929 µM 3.32727511482864 0.000326766933734793 yes 17 0.000438498717824146 6 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2587 piperic acid 92.2 µM 3.27555141016089 0.000396512575157827 yes 18 0.00052727959385736 12 5370536
SGTC_86 0417-1630 471.922 µM 3.27231451085735 0.000401306853948508 yes 19 0.000533354207201335 42 3634867
SGTC_1956 st077085 54 µM 3.25050831149627 0.000435033027221516 yes 20 0.000575994505445417 7 24208685
SGTC_2969 9091408 28.7 µM 3.18071020595859 0.000561464184586197 yes 21 0.000734572558241829 16 4286311
SGTC_2273 7815444 169.05 µM 3.05790281126938 0.000869345289633183 yes 22 0.00111445926326013 14 2824616
SGTC_3046 9092212 49.47 µM 3.05356017113845 0.000882649074531286 yes 23 0.00113071682782622 7 25236637
SGTC_6 0844-0013 19.835 µM 3.02541274569863 0.000973517600224825 yes 24 0.00124147017274958 28 1584900
SGTC_929 2805-0021 398 µM 2.99600639648975 0.00107755909474841 no 25 0.00136770347867911 13 3098024
SGTC_1608 st001473 40.5 µM 2.99290374752479 0.00108911121882425 no 26 0.00138168442748845 20 7292267
SGTC_936 3005-4620 401 µM 2.97929351408754 0.00114113973595768 no 27 0.00144456940477204 10 777207
SGTC_2484 5809818 12.04 µM 2.96299176939034 0.00120644963561301 no 28 0.00152332357702713 9 2870548
SGTC_686 1319-0111 510 µM 2.94069540716203 0.00130132004790027 no 29 0.00163738188149167 24 4562600
SGTC_3057 9095946 49.47 µM 2.93217749249892 0.00133932945490576 no 30 0.00168297158226962 15 24540043
SGTC_284 0988-0104 32.6 µM 2.91812780775355 0.00140424583613251 no 31 0.00176069991541997 9 4666532
SGTC_1955 wogonin 32.4 µM 2.90696539501494 0.00145785600910722 no 32 0.0018247678417927 13 5281703 A flavanone.
SGTC_2280 7785178 200 µM 2.86213622130985 0.00169249754541654 no 33 0.00210398003627387 9 2954328
SGTC_2487 5918373 44.05 µM 2.83255803365803 0.00186562290397594 no 34 0.00230885915874664 19 2876279
SGTC_2336 9001819 198.65 µM 2.8130494534843 0.00198846115765056 no 35 0.00245370516197585 61 2989602
SGTC_2583 asiatic acid 100 µM 2.81075115921745 0.00200340613799368 no 36 0.00247129979342389 28 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2991 9074669 71.4286 µM 2.7557227408918 0.0023930986070174 no 37 0.0029281307656143 50 17333109
SGTC_1179 1021-1431 9.29 µM 2.74700460203007 0.00246077724870284 no 38 0.0030071145292523 22 2840958
SGTC_2287 7945887 168.79 µM 2.7017219406605 0.00284095343375675 no 39 0.00344907122944701 11 1245853
SGTC_1851 st056236 18.9 µM 2.69170573577286 0.00293188997624766 no 40 0.00355438187087983 26 5393171
SGTC_1221 2958-7315 257 µM 2.69141259574929 0.00293459045855738 no 41 0.00355750697158644 19 4562705
SGTC_2761 levamisole 97.89 µM 2.66987082169358 0.00313928253207784 no 42 0.00379402167792775 14 26879 An alkaline phosphatase inhibitor.
SGTC_2271 7849410 118.62 µM 2.65322322275622 0.00330617803606567 no 43 0.00398635630795825 13 972430
SGTC_710 3448-4187 58 µM 2.65314387594539 0.00330699225294081 no 44 0.00398729356121374 21 3946412
SGTC_538 2922-0838 53.3 µM 2.63976115433044 0.00344692636429456 no 45 0.00414822372936593 25 777039
SGTC_592 k241-0073 46.5 µM 2.63209285465439 0.0035294847903138 no 46 0.004243033326389 19 4230158
SGTC_2871 9038510 12.99 µM 2.61864304526202 0.00367858564592561 no 47 0.00441401350880655 28 4945164
SGTC_401 neomycin 50 µM 2.61695284968844 0.00369771692813023 no 48 0.00443592976474588 12 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3301 9125354 19.7965 µM 2.58467491484056 0.00408060748027021 no 49 0.00487354251633704 15 41905162
SGTC_860 0443-0016 25.1 µM 2.56755826147905 0.0042977262145887 no 50 0.0051208788492851 32 5337942
SGTC_1672 st016598 6.51 µM 2.55516582019914 0.00446130565710893 no 51 0.00530686110819898 43 4665860 YNL267W PIK1
SGTC_1006 4099-6547 255 µM 2.52616232315412 0.00486607855959384 no 52 0.00576580931987022 27 3146833
SGTC_1759 st043059 70 µM 2.52545055740693 0.00487641079244457 no 53 0.0057775019804489 30 669426
SGTC_2426 5582046 32.21 µM 2.50332793084335 0.00520745491479231 no 54 0.00615157444949071 22 2251934
SGTC_2944 9067346 25.62 µM 2.48552249280199 0.00548826640795224 no 55 0.00646807059936917 37 6473075
SGTC_1963 st076565 50.3 µM 2.47346264615992 0.00568602901431752 no 56 0.00669053958810013 25 4914280
SGTC_1853 st056710 91.2 µM 2.47180879982522 0.0057136370523516 no 57 0.00672156967584852 25 269167
SGTC_3307 9126885 69.2785 µM 2.44711137394989 0.00614030569072356 no 58 0.00720031660244126 23 24824909
SGTC_2824 7998404 51.95 µM 2.43758072952413 0.00631235824080591 no 59 0.00739295613870459 33 837851
SGTC_1331 1472-0049 76.2 µM 2.42632867106758 0.0065209696462829 no 60 0.00762622505247834 27 24051409
SGTC_2446 5162541 200 µM 2.41899676210923 0.00666016164999657 no 61 0.00778168937156026 27 1549321
SGTC_1953 st076800 12.1 µM 2.40839383753218 0.0068660964446288 no 62 0.0080114428078442 48 297591
SGTC_3274 9138298 49.47 µM 2.40054667668242 0.00702210871183627 no 63 0.00818530138543947 31 17015756
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 2.35518338858187 0.00798679064195651 no 64 0.00925678318136829 18 364106
SGTC_3349 9149703 23.001 µM 2.34746683886377 0.0081620036091501 no 65 0.0094507778006318 15 4910494
SGTC_555 4296-0685 37 µM 2.33983135309266 0.00833869121572323 no 66 0.00964622469015711 34 2908540 YHR072W ERG7
SGTC_2904 7225135 42.03 µM 2.33635335488248 0.00842028046640503 no 67 0.00973641644115185 31 4446116
SGTC_2973 9094665 17.96 µM 2.32585917012755 0.00867072229513046 no 68 0.0100130324125145 64 25237061 YIL048W NEO1
SGTC_3289 9119912 71.43 µM 2.3143200740742 0.00895361905627096 no 69 0.0103250857292657 29 17014829
SGTC_462 ag-879 158 µM 2.293028836009 0.00949688077294068 no 70 0.010923172427955 52 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1603 st002045 67.8 µM 2.29240158164898 0.00951331351113295 no 71 0.0109412404232685 15 5887985
SGTC_1958 st076513 41.9 µM 2.2896611449063 0.0095853990749268 no 72 0.0110204837357718 34 732122 YGL099W LSG1
SGTC_637 1181-0519 7.26 µM 2.27595808690284 0.00995305736603679 no 73 0.0114242591596998 46 6252091 YGR060W ERG25
SGTC_1716 st033144 30.6155 µM 2.27531864086182 0.00997051059910489 no 74 0.0114434109997471 42 674617
SGTC_2477 5967686 25.23 µM 2.26394078080678 0.0102855585903397 no 75 0.011788878644642 38 776118
SGTC_515 4092-1064 102 µM 2.26268162756425 0.0103209518767784 no 76 0.0118276610890271 58 717353
SGTC_2949 9072542 2.23 µM 2.24257425536055 0.0109007030689903 no 77 0.0124621409728632 51 16457352
SGTC_2428 5615643 7.78 µM 2.23054911399969 0.0112607966291335 no 78 0.0128555053482899 54 2253075
SGTC_306 1672-3436 11.6 µM 2.21886141945579 0.0116206492102208 no 79 0.0132480769722821 32 6797378
SGTC_2716 st080858 38.6235 µM 2.20324309209008 0.0121170806496448 no 80 0.0137888097884272 28 5296050
SGTC_1555 citronellol 128 µM 2.19963860399904 0.0122342269004039 no 81 0.0139162729871164 27 8842 A terpine precursor.
SGTC_451 chloral hydrate 100 µM 2.19689671154187 0.0123239947310816 no 82 0.0140139118850535 65 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_509 pifithrin 175 µM 2.18954738810146 0.012567426709949 no 83 0.0142785391003522 32 4817 A p53 inhibitor.
SGTC_2417 cerulenin 830 nM 2.18789556143468 0.0126227096487431 no 84 0.0143386053477242 43 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2649 anisomycin 9.56 µM 2.18440368356434 0.0127402681280841 no 85 0.014466298896489 39 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_934 2950-0684 338 µM 2.16497422060276 0.0134118327924674 no 86 0.0151948297719681 34 1121253
SGTC_591 4299-0174 154 µM 2.13916084753776 0.0143511801977257 no 87 0.0162113219306305 27 5509088
SGTC_931 2812-0076 566 µM 2.13598202880376 0.0144706856140592 no 88 0.0163404393324867 36 3450959
SGTC_2425 5628681 7.85 µM 2.13556318002226 0.0144864956302198 no 89 0.0163575176407459 38 5714958
SGTC_1908 st060353 56.5 µM 2.12338937536686 0.0149525531314472 no 90 0.0168606183904001 55 4227716
SGTC_597 k018-0003 82.8 µM 2.12192381980313 0.0150095198717899 no 91 0.016922067905121 34 6786234
SGTC_1999 st074831 12.5 µM 2.10433855848834 0.0157077444681434 no 92 0.0176744624221767 56 17112523
SGTC_2368 9071271 200 µM 2.10125369533483 0.0158330592594093 no 93 0.0178093510723527 34 27209959
SGTC_949 1165-0505 146 µM 2.10072662563237 0.0158545556699755 no 94 0.017832485328789 29 6244267
SGTC_450 aminopyrene 156 nM 2.09940299111902 0.0159086501569803 no 95 0.0178906956260008 46 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_838 0109-0203 71.4 µM 2.09902783176705 0.0159240109758938 no 96 0.0179072236884248 36 759422
SGTC_2020 4017018 200 µM 2.09832988715042 0.0159526220037753 no 97 0.0179380070646754 45 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1710 st031758 61.5 µM 2.08688246117775 0.0164282157982287 no 98 0.0184493803351762 45 5394341
SGTC_170 4197-0004 226 µM 2.08058490468315 0.0166949925084328 no 99 0.0187359583888457 61 218692
SGTC_2357 9067248 200 µM 2.07129708747593 0.0170952023434304 no 100 0.019165520651028 34 9150235
SGTC_2936 9038235 15.59 µM 2.06996673114022 0.0171531930939649 no 101 0.0192277300168439 61 4749415
SGTC_442 cape 100 µM 2.06813102322994 0.0172334882698505 no 102 0.0193138520919429 27 5281787
SGTC_2612 dictamnine 15.46 µM 2.0636183628556 0.0174322413627271 no 103 0.0195269575726924 84 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2892 9047358 58.44 µM 2.05067674164605 0.018013123672608 no 104 0.0201492187110423 39 6466771
SGTC_216 k038-0035 28.382 µM 2.04900270802903 0.0180894544402276 no 105 0.0202309250612363 67 4444231 YPR107C YTH1
SGTC_3321 9137793 26.8275 µM 2.0488637491631 0.0180958029111106 no 106 0.0202377199844189 64 4904192
SGTC_2610 ononetin 44.17 µM 2.0357462898611 0.0187036995333229 no 107 0.0208879191324861 44 259632
SGTC_743 1275-0778 158 µM 2.03231313702828 0.0188656409339772 no 108 0.0210609826847463 62 2849257 YMR203W TOM40
SGTC_2998 9066762 71.4286 µM 2.03098786727825 0.018928472078689 no 109 0.0211281126900428 51 4945196
SGTC_3092 9117248 49.47 µM 2.02597804604774 0.0191675987733073 no 110 0.0213835172205331 30 17141857
SGTC_880 0833-0487 87.2 µM 2.02045462907674 0.019434211925917 no 111 0.0216681259019147 37 76075
SGTC_2582 agaric acid 100 µM 2.01418634648254 0.0197405894389764 no 112 0.0219949863137355 80 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_366 0181-0206 4.31 µM 2.01111539999015 0.0198921796846175 no 113 0.0221566344530599 55 274874
SGTC_215 1287-0124 461.5 µM 2.01006569929379 0.0199442217774958 no 114 0.0222121179030975 27 5560863
SGTC_83 0170-0301 39.027 µM 1.99484000210392 0.0207121657303579 no 115 0.0230301664745352 21 3089716
SGTC_2091 4-phenylthiadiazole 200 µM 1.98970052111483 0.0209769774041462 no 116 0.023311967634416 46 270010
SGTC_2735 sertaconazole 140 nM 1.97955122447903 0.0215083417923817 no 117 0.0238769891648601 45 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2319 6033012 152.6 µM 1.97531554143685 0.0217334413266443 no 118 0.0241161753173405 44 847246
SGTC_1914 st062367 72.6 µM 1.96737352273847 0.022160874787985 no 119 0.0245700822514534 65 978205
SGTC_1104 tacrolimus 29.8 µM 1.96481423676191 0.02230011619354 no 120 0.0247178709084593 72 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2844 9010103 25.97 µM 1.96241555236091 0.0224312891995378 no 121 0.0248570617739327 56 2480525
SGTC_590 k048-0076 22.4 µM 1.95668360987295 0.0227473802778756 no 122 0.0251923390332877 59 6832814
SGTC_877 0771-0151 33.1 µM 1.95468351253868 0.0228585565297926 no 123 0.025310218657188 45 6166523
SGTC_2376 9072922 81.32 µM 1.95390638801114 0.0229018766447619 no 124 0.0253561444900419 45 17087968
SGTC_8 0354-0001 70 µM 1.94133492978359 0.0236123257206841 no 125 0.0261088326772775 70 4993152
SGTC_771 0250-0039 27.3 µM 1.93971325776293 0.0237053067384049 no 126 0.0262072737278891 58 3005115
SGTC_947 3447-0010 211 µM 1.93935038110913 0.0237261549211003 no 127 0.0262293440236773 67 748350
SGTC_2270 7924575 90.91 µM 1.93384389171135 0.0240444133163839 no 128 0.0265661622083677 55 1262135
SGTC_1617 st002906 78 µM 1.92714469812448 0.0244364353944432 no 129 0.0269807998111526 44 5150859
SGTC_837 0091-0265 12.5 µM 1.90634598200452 0.0256878702300696 no 130 0.0283026660710689 68 759367
SGTC_3245 9134821 49.47 µM 1.89375513001196 0.0264711962156595 no 131 0.0291287599708243 62 17014901
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.88414662753597 0.0270823207459622 no 132 0.0297725723163373 46 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2416 tofa 880 nM 1.88377060907213 0.0271064738693099 no 133 0.0297980053709881 43 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2499 avocadenofuran 51.48 µM 1.88047607527121 0.0273188641763742 no 134 0.0300216120092868 49 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2342 7990637 118.86 µM 1.87407789829356 0.0277353046162585 no 135 0.0304598445617697 83 2033102 YER133W GLC7
SGTC_479 n-linoleoylglycine 10 µM 1.87182786812288 0.0278830047067288 no 136 0.0306152107210195 59 6433346 An anti-infammatory.
SGTC_435 c-PAF 6.7 µM 1.87080848411443 0.0279501361002392 no 137 0.0306858156196324 68 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1235 benzylparaben 21.5 µM 1.86494509403151 0.0283388878859324 no 138 0.0310945503686812 60 7180
SGTC_2276 7947513 42.08 µM 1.86156139729846 0.0285652727043466 no 139 0.0313324694011365 49 2105100
SGTC_1144 3486-0183 12.5 µM 1.85704841819235 0.0288695509264434 no 140 0.0316521329241467 67 6744069
SGTC_2371 9071574 200 µM 1.8394795490245 0.0300798668935659 no 141 0.032922341603449 54 45596039
SGTC_2690 usnic acid 100 µM 1.83903664119873 0.0301109142613032 no 142 0.0329548984600986 57 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3148 9097893 49.47 µM 1.83617446772288 0.0303121907688838 no 143 0.0331659287680981 56 17174100
SGTC_70 0141-0289 43.283 µM 1.83298101419848 0.0305380785735337 no 144 0.0334026972864255 81 352408
SGTC_186 3455-3465 67.277 µM 1.83006631583504 0.0307454640799607 no 145 0.0336200115333539 53 755278
SGTC_3243 9134147 49.47 µM 1.82106886549834 0.0313930145517014 no 146 0.0342981946542908 50 24282180
SGTC_2040 5100729 123 µM 1.80938278595058 0.0322508608297585 no 147 0.0351957777994216 66 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1624 st003710 6.25 µM 1.80839184597811 0.032324484684016 no 148 0.0352727680546704 55 24207033
SGTC_119 0121-0043 24.815 µM 1.80485086303897 0.0325887031942285 no 149 0.0355490113339852 98 1092378
SGTC_102 gallobenzophenone 83.616 µM 1.80422594539291 0.0326355172627548 no 150 0.0355979467775947 64 70837
SGTC_2992 9074591 71.4286 µM 1.80127820205957 0.0328570881127218 no 151 0.0358295208863611 64 17741321
SGTC_1013 4112-3890 241 µM 1.79774762715827 0.0331240987306579 no 152 0.036108505117939 74 705171
SGTC_1842 st055362 61.2 µM 1.79771948753125 0.0331262340361675 no 153 0.0361107358220763 46 676032
SGTC_2956 9076196 2.52 µM 1.79505113376956 0.0333292312444391 no 154 0.0363227766897 59 16423868
SGTC_323 4013-0906 34.3 µM 1.79443517777644 0.0333762358456348 no 155 0.0363718681711353 51 2910086
SGTC_2188 6126565 140.678 µM 1.79070392530136 0.0336621419513824 no 156 0.0366704097430832 58 874518
SGTC_2349 9023730 187.07 µM 1.78658776096326 0.033979876775548 no 157 0.0370020706446369 51 4126287
SGTC_551 k048-0028 34.9 µM 1.77450418039046 0.0349269064302748 no 158 0.0379898956149414 83 6836383
SGTC_1365 1672-3266 55.4 µM 1.7702276155682 0.03526722230797 no 159 0.038344615355712 77 6415873
SGTC_1108 betulinic acid 729.144 nM 1.7645971695143 0.0357194189648763 no 160 0.0388157457660831 65 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.76237569415155 0.0358991340882178 no 161 0.0390029212390452 65 3256 An antibiotic and ribosome inhibitor.
SGTC_1281 0884-0031 11.8 µM 1.76147776823977 0.0359719853009231 no 162 0.0390787862960024 72 1548255
SGTC_966 1300-0360 30.2 µM 1.75722325961553 0.0363188133106284 no 163 0.0394398810802198 86 70588
SGTC_124 0136-0217 7.121 µM 1.75267337985994 0.0366927439469985 no 164 0.0398290437936278 102 3976905
SGTC_482 fipronil 114 µM 1.74805387820301 0.0370756121364335 no 165 0.0402273491733031 38 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_478 N-arachidonylglycine 10 µM 1.74585315563007 0.037259154817704 no 166 0.0404182357883709 20 5283389
SGTC_912 3474-0017 2.18 µM 1.74362474317364 0.0374457626219528 no 167 0.040612272930876 64 3360550
SGTC_554 4483-2211 187 µM 1.7402348727066 0.0377310943041201 no 168 0.0409088922913494 47 747107
SGTC_3098 9119039 49.47 µM 1.73878647431931 0.0378535486213628 no 169 0.0410361643025741 71 17161528
SGTC_932 2857-0803 154 µM 1.7379389499331 0.0379253525446878 no 170 0.0411107858034347 73 674898
SGTC_2165 5727197 32.143 µM 1.73752194589091 0.0379607227137185 no 171 0.0411475418903354 54 1361712
SGTC_2049 5262831 67.185 µM 1.73743304681077 0.0379682665887341 no 172 0.0411553811879283 75 763417
SGTC_3067 9117431 49.47 µM 1.73311427339477 0.0383362283900041 no 173 0.0415376799495878 101 17150885
SGTC_2718 lomofungin 53.02 µM 1.72441318443473 0.039086395176395 no 174 0.0423166395544259 70 5351222 A RNA synthesis inhibitor.
SGTC_1516 st013856 110 µM 1.72394208114608 0.039127350123613 no 175 0.0423591497777924 62 5281404 A mutagen and neurotoxin.
SGTC_2482 5981709 142.65 µM 1.72310951842365 0.0391998136388181 no 176 0.0424343609279784 87 877755
SGTC_2381 9035592 200 µM 1.71934061936054 0.0395292137500323 no 177 0.0427761838980201 65 4749657
SGTC_1033 k072-0102 21.3 µM 1.71569853551884 0.0398496658633005 no 178 0.0431086164790944 71 5965931
SGTC_2731 amoxapine 43.43 µM 1.71337095595335 0.0400555638352144 no 179 0.043322158023473 59 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3088 9117578 49.47 µM 1.71192155527708 0.0401842141553519 no 180 0.0434555628696301 76 678341
SGTC_29 0299-0004 12.984 µM 1.71010116012496 0.0403462696458216 no 181 0.0436235841554877 44 16871 A napthoquinone isolated from Swertia calycina.
SGTC_80 0159-0065 512.242 µM 1.70575550829641 0.0407352751909614 no 182 0.0440268050037205 33 1548079
SGTC_782 0083-0095 30.5 µM 1.70320846024373 0.0409646879808561 no 183 0.0442645319916371 68 3591729 An indicator and reagent.
SGTC_1893 st059353 36.1 µM 1.70285660368168 0.040996461949225 no 184 0.0442974534663774 85 3112488
SGTC_2823 7987624 58.44 µM 1.70276862664549 0.041004409728866 no 185 0.0443056881248841 98 2239440
SGTC_503 tyrphostin 8 294 µM 1.70233528973084 0.0410435753002723 no 186 0.0443462665050204 81 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_189 3970-0742 2.116 µM 1.70156538963427 0.0411132347336456 no 187 0.0444184350868138 60 2891807
SGTC_2528 xanthyletin 44.79 µM 1.69669720852215 0.0415559231199284 no 188 0.0448769603558025 71 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3161 9100388 49.47 µM 1.6854467071502 0.0425937707699284 no 189 0.0459512093264584 72 25236368
SGTC_2427 5545055 42.75 µM 1.68078432763451 0.0430299681952273 no 190 0.0464024069471776 72 5372858
SGTC_1964 st076914 61 µM 1.67232202716603 0.0438308892427134 no 191 0.0472304191816172 96 24208661
SGTC_2658 polymyxin b sulfate 77.05 µM 1.67107812306256 0.043949626848612 no 192 0.0473531239477814 86 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1514 1189-1591 158 µM 1.66870139600752 0.0441772200444824 no 193 0.0475882861778132 80 767698 YMR146C TIF34
SGTC_137 0438-0332 85.389 µM 1.66830655645166 0.0442151213857688 no 194 0.0476274435305322 118 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1973 st070275 50.2 µM 1.66227325525713 0.0447975353571969 no 195 0.0482289988633737 52 17118334
SGTC_680 0417-1641 114 µM 1.66092870425737 0.0449281672537452 no 196 0.0483638832611198 79 2835990
SGTC_3051 9093778 49.47 µM 1.65361815509461 0.045643810174115 no 197 0.0491025607576856 81 17217378
SGTC_3175 9106517 49.47 µM 1.65212895581995 0.0457907081609551 no 198 0.0492541326405242 73 41468073
SGTC_3140 9094243 49.47 µM 1.64840744107572 0.0461594683340707 no 199 0.0496345450497281 80 19291112
SGTC_3143 9086658 49.47 µM 1.64753592378682 0.0462461696368902 no 200 0.0497239692990764 91 25236626
SGTC_3035 9091303 49.47 µM 1.64750818157157 0.0462489316665416 no 201 0.0497268179692487 70 25237002
SGTC_1780 st038448 24.544 µM 1.64053009412332 0.0469478916736816 no 202 0.0504474982587517 77 728868 YDL195W SEC31
SGTC_288 1315-0019 35.1 µM 1.63760176675293 0.0472437196411245 no 203 0.0507523971394329 116 6811474
SGTC_532 1548-0774 215 µM 1.63316291212775 0.047694992272197 no 204 0.0512173689578828 93 5932993
SGTC_894 0960-0238 55.9 µM 1.6257629198242 0.0484549747681072 no 205 0.0520000496288128 91 6741907 YDL195W SEC31
SGTC_52 0329-0193 875 nM 1.62128814631034 0.0489192146956653 no 206 0.052477928011855 80 3739292
SGTC_2062 5245942 200 µM 1.61992519955135 0.0490613189248316 no 207 0.0526241729636384 70 1376160
SGTC_1659 st012954 42.1 µM 1.61740595688754 0.0493248493334444 no 208 0.0528953403720196 69 24207262
SGTC_2768 sulfasalazine 50.2 µM 1.61603129407098 0.0494691245819338 no 209 0.053043773685897 80 5384001 An antioxidant and salicylic acid derivative.
SGTC_279 1273-0055 2.93 µM 1.61311511361837 0.0497763022163672 no 210 0.0533597504550984 89 2847562
SGTC_1306 1185-0270 9.02 µM 1.60732506648535 0.0503907091833729 no 211 0.0539915391744738 81 1548076
SGTC_619 1652-1634 108 µM 1.60610925408864 0.0505204888583774 no 212 0.0541249534738189 80 5400454
SGTC_1784 st039334 36.3 µM 1.59863776854659 0.0513238748389305 no 213 0.0549505562886615 100 3496984
SGTC_1778 st046819 58.9 µM 1.58867498001098 0.0524109163137902 no 214 0.0560668952212654 103 671715
SGTC_2723 salbutamol 83.58 µM 1.5871730887149 0.0525763618799494 no 215 0.0562367239917937 70 9884233 β2-adrenoceptor agonist
SGTC_2846 9008642 19.48 µM 1.58473760217139 0.0528455313513531 no 216 0.0565129823450766 99 2992898
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.58000256683127 0.0533719742865661 no 217 0.0570531393238489 83 279621
SGTC_960 1222-0186 7.7 µM 1.57759245926829 0.0536415225100668 no 218 0.0573296329287275 92 3126296
SGTC_3340 9146634 11.102 µM 1.57598865095151 0.0538214903827838 no 219 0.0575142093669098 69 4907387
SGTC_1587 estradiol valerate 56.1 µM 1.57384205527036 0.0540631138065559 no 220 0.0577619843550382 99 13791 A steroid.
SGTC_365 0121-0052 13.6 µM 1.56398459845723 0.0551837236191689 no 221 0.058910592701381 84 3101739
SGTC_464 bw-b 70c 158 µM 1.56351546463485 0.0552375094088327 no 222 0.0589657005672819 95 5353454
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.5632541210722 0.0552674901767741 no 223 0.0589964174165254 84 115019
SGTC_2785 7756463 72.73 µM 1.56208574143288 0.0554016813519422 no 224 0.059133895709592 125 2201551
SGTC_3206 9114350 49.47 µM 1.5611013325557 0.0555149426285138 no 225 0.0592499218685364 74 17087243
SGTC_1792 st045773 43.6 µM 1.55932775348545 0.0557194632346758 no 226 0.0594594130828783 29 2919270
SGTC_935 2996-0153 430 µM 1.55545422739301 0.0561682068566946 no 227 0.0599189638943504 93 23738523
SGTC_1328 1441-0025 69.2 µM 1.54325139899227 0.0576005393810358 no 228 0.0613848953513267 72 4562601
SGTC_2123 5259487 200 µM 1.54278686871534 0.0576556269837376 no 229 0.0614412482789485 88 2173474
SGTC_3163 9099914 49.47 µM 1.54143683835187 0.0578159592435885 no 230 0.0616052520545781 84 16268368
SGTC_1405 3909-7894 12 µM 1.54096709640571 0.0578718288499563 no 231 0.0616623971301892 77 7104060
SGTC_1435 4092-0789 56.7 µM 1.5400551370889 0.057980415547027 no 232 0.061773457024513 110 2248285
SGTC_3017 9080681 49.47 µM 1.53779196633366 0.0582505823618824 no 233 0.0620497442530924 81 16451914
SGTC_2922 7999257 32.47 µM 1.53591017093962 0.0584759745110541 no 234 0.0622802066382522 90 2988377
SGTC_3036 9090181 49.47 µM 1.53569388647973 0.0585019238136698 no 235 0.0623067375893913 83 25236586
SGTC_2227 7312221 64.1025 µM 1.53421063339693 0.0586801247444154 no 236 0.0624889212594796 85 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2630 antimycin a 100 µM 1.53331070303313 0.0587884516507833 no 237 0.0625996593651908 97 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2356 9061756 188.97 µM 1.53210725148115 0.0589335593703114 no 238 0.0627479853043975 82 20104043
SGTC_974 1326-0144 138 µM 1.53191042107325 0.058957319167222 no 239 0.0627722707789389 95 5411856
SGTC_1464 k208-0027 110 µM 1.53107089526159 0.0590587444254822 no 240 0.0628759360240636 110 X1464
SGTC_754 3474-0146 171 µM 1.52933542119718 0.0592688453585512 no 241 0.0630906564147827 90 24762078
SGTC_2019 4016004 108 µM 1.52889192488625 0.0593226300705302 no 242 0.0631456192178664 106 45595336
SGTC_1996 st072960 66.8 µM 1.52755694972055 0.0594847592577026 no 243 0.0633112886729481 94 1719405
SGTC_2338 7999974 200 µM 1.52671782221883 0.0595868466998453 no 244 0.0634155968618269 105 315925
SGTC_380 3970-0968 6 µM 1.52521833521031 0.059769614685195 no 245 0.0636023244182341 86 2891601
SGTC_1561 5-methoxyflavone 52.9 µM 1.52421117259139 0.0598926210857276 no 246 0.0637279839788786 87 94525
SGTC_1392 3455-1037 33.9 µM 1.52338295235251 0.0599939214569793 no 247 0.0638314622726595 90 981132
SGTC_131 0141-0277 33.849 µM 1.52271316782963 0.060075941501043 no 248 0.0639152410605631 113 1547771
SGTC_1134 3477-0009 42.5 µM 1.52225267594756 0.0601323830360033 no 249 0.0639728904457312 111 3973534
SGTC_3022 9087993 49.47 µM 1.52216179715132 0.0601435267651384 no 250 0.063984272418197 83 17173644
SGTC_2242 6630449 61.2675 µM 1.51980372762372 0.0604332433241052 no 251 0.064280155995149 85 691249 YDR170C SEC7
SGTC_2673 kobusone 100 µM 1.51848946763871 0.0605951889038698 no 252 0.0644455263288455 79 6710676 An epoxy ketone and protein crosslinker.
SGTC_146 3448-8650 53.125 µM 1.51775464141074 0.0606858834277676 no 253 0.064538131803058 110 2891488 YIL048W NEO1
SGTC_741 4582-0002 126 µM 1.51397513236124 0.0611540405817046 no 254 0.0650160733607206 100 2912688
SGTC_1127 asiatic acid 681.4 nM 1.50776266193932 0.0619296886229579 no 255 0.0658076407577452 89 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1746 st038117 42 µM 1.50016519719972 0.0628886694091544 no 256 0.066785807975531 97 2898218
SGTC_3135 9127742 49.47 µM 1.49991785969255 0.0629200826504968 no 257 0.066817840539395 88 3643468
SGTC_903 1134-0042 114 µM 1.49764202090061 0.0632097008618402 no 258 0.0671131415007422 84 701009
SGTC_868 0527-0199 213 µM 1.49025310480613 0.0641571575519349 no 259 0.0680788489493278 99 2849450
SGTC_2178 5812956 200 µM 1.4867073515883 0.0646157203951667 no 260 0.0685460601000685 90 5403383
SGTC_3280 9140961 49.47 µM 1.48478065916429 0.0648659596904935 no 261 0.0688009684505216 97 4901226
SGTC_187 1488-2104 32.728 µM 1.47216297919293 0.0665233870102344 no 262 0.0704884359365197 87 2852859
SGTC_540 1187-0821 17.3 µM 1.47166397007718 0.0665896033378584 no 263 0.0705558208531567 109 847520
SGTC_2323 6148992 148.28 µM 1.46660678535168 0.0672635511144506 no 264 0.0712415265698235 93 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2805 7950783 58.44 µM 1.46537196112257 0.0674289087624279 no 265 0.0714097314956939 99 1178958 YDL195W SEC31
SGTC_909 3448-9333 149 µM 1.45830103512206 0.0683818469768378 no 266 0.0723787925215521 103 3344074
SGTC_1005 4092-0690 4.4 µM 1.45679866019462 0.0685856519183278 no 267 0.0725859829290218 124 1529343
SGTC_640 3381-0960 37.1 µM 1.45453738405717 0.0688932885941592 no 268 0.0728986883515716 111 1745025
SGTC_2314 7727897 200 µM 1.44762328318892 0.0698405220497699 no 269 0.0738612179440386 77 900724
SGTC_45 0kpi-0036 14.9 µM 1.44593046676158 0.0700739587510448 no 270 0.0740983527735339 90 2795021
SGTC_1751 st044839 27.194 µM 1.4435617998747 0.0704016011129541 no 271 0.0744311384295111 95 5291326
SGTC_162 k030-0015 37.8 µM 1.44090216404361 0.0707708936862395 no 272 0.0748061623181668 103 1809920 YMR134W ERG29
SGTC_2686 alizarin 95.37 µM 1.44060166939115 0.0708127110199689 no 273 0.0748486242684057 92 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_3223 9129970 49.47 µM 1.4400394378121 0.0708910030835561 no 274 0.0749281208212103 111 17248386
SGTC_2733 amorolfine 100 µM 1.43881607794395 0.0710615885505523 no 275 0.0751013199110759 110 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_937 3122-0005 46.7 µM 1.43658537053497 0.0713734499310037 no 276 0.0754179214599627 101 759535
SGTC_1622 st003707 19.4 µM 1.43541731687859 0.0715371667758327 no 277 0.0755841071368337 101 10140899
SGTC_2208 7283366 200 µM 1.43306833893591 0.0718672766821341 no 278 0.0759191542169592 107 898663
SGTC_1558 st069300 45.6 µM 1.42473742880475 0.0730474714621385 no 279 0.0771165577178798 106 24208000
SGTC_2857 9024691 58.44 µM 1.42472354279896 0.0730494509247595 no 280 0.0771185654675813 114 16478292
SGTC_1539 benzyladenosine 56 µM 1.42449401113591 0.0730821768176652 no 281 0.0771517587450883 106 92208 A nucleotide analog.
SGTC_2317 5986382 200 µM 1.42281901312505 0.0733213324618593 no 282 0.077394314090121 109 877883
SGTC_1100 amiodarone 5.07 µM 1.42116289696001 0.0735583802791106 no 283 0.0776347041674031 81 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_781 4335-2806 94.4 µM 1.41832039289002 0.0739666068715267 no 284 0.0780486227512111 120 845254
SGTC_967 1306-0166 352 µM 1.4158986889907 0.0743157638831197 no 285 0.0784025844280201 124 4437607
SGTC_2755 lomerizine 42.69 µM 1.41333625620055 0.0746865798710771 no 286 0.0787784392055003 89 3949 A calcium channel blocker.
SGTC_1318 1280-3875 124 µM 1.39742174384558 0.0770212952999661 no 287 0.0811433921130627 124 373245
SGTC_3121 9125696 49.47 µM 1.38963721760748 0.0781833248233127 no 288 0.0823195341077509 86 1235365
SGTC_740 k014-0057 261 µM 1.38626544975138 0.0786907508454264 no 289 0.0828329313646852 118 4012779
SGTC_1040 k898-0338 155 µM 1.38547415356858 0.0788101958307909 no 290 0.0829537651922586 108 20969351
SGTC_906 1165-0455 526 µM 1.3854482868836 0.0788141026858613 no 291 0.0829577173666923 108 3252859
SGTC_3302 9125395 16.351 µM 1.38372447152333 0.0790747953586575 no 292 0.0832214187147628 105 17599668
SGTC_1323 1348-1351 11.2 µM 1.38248697435128 0.0792623444069639 no 293 0.0834111136189049 104 6989654
SGTC_2079 5212404 121 µM 1.38125172850355 0.0794498879068679 no 294 0.0836007873457026 90 758462
SGTC_3192 9110362 49.47 µM 1.37934678868524 0.0797397669741221 no 295 0.0838939285086074 101 16649480
SGTC_552 k242-0005 476 µM 1.37788761427204 0.0799623534842435 no 296 0.0841189947886825 125 4088318
SGTC_3015 9080845 49.47 µM 1.37761879681379 0.0800034108438067 no 297 0.0841605071845058 114 5296973
SGTC_676 falcarinol 140 µM 1.3751960415594 0.0803741655498846 no 298 0.0845353376006813 118 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_689 0833-0039 98 µM 1.37429134296724 0.0805129441639797 no 299 0.0846756264109704 109 5374726
SGTC_2222 6885208 172.143 µM 1.37369852703899 0.0806039788380922 no 300 0.0847676471873926 89 609514
SGTC_2895 9054447 58.44 µM 1.37113816559097 0.0809980491352408 no 301 0.0851659447487796 114 2697450
SGTC_1793 st048256 72.231 µM 1.36853376208311 0.0814003881634307 no 302 0.0855725307122355 103 672022
SGTC_3023 9089636 49.47 µM 1.3683255417811 0.0814326198569781 no 303 0.0856050996262537 101 17249241
SGTC_1588 farnesol 29.9 µM 1.36517146140823 0.081922037179028 no 304 0.0860995829086075 116 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_723 4182-0001 115 µM 1.3637655063661 0.0821409115363224 no 305 0.0863206898566247 110 744821 YLR208W SEC13
SGTC_2117 5521686 200 µM 1.36247478439444 0.0823422343577062 no 306 0.0865240483237647 111 803312
SGTC_2071 5230951 39.92 µM 1.36032373131307 0.0826785742346736 no 307 0.0868637509031207 131 1799272
SGTC_3256 9138902 49.47 µM 1.35649319938174 0.0832800767221144 no 308 0.0874711488437915 109 17228773
SGTC_1063 disulfiram 1.84 µM 1.35475891373346 0.0835534883940347 no 309 0.0877471904072635 120 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1883 5-benzylidenerhodanine 20 µM 1.35186207143952 0.0840116815974881 no 310 0.0882097214487441 115 1273210
SGTC_1224 0823-0416 294 µM 1.34343304661943 0.085355629298238 no 311 0.0895658961226984 108 3598164
SGTC_845 0330-0138 4.51 µM 1.33966350200577 0.0859618417501274 no 312 0.0901773842474998 136 9039800
SGTC_528 3492-0019 172 µM 1.33459959924059 0.0867812744078067 no 313 0.091003714635708 140 2869262
SGTC_5 0352-0601 109.883 µM 1.33262824493835 0.0871018494060618 no 314 0.0913269156919985 101 762456
SGTC_2308 7584454 197.62 µM 1.32827039084162 0.0878136460669618 no 315 0.0920443988096546 127 893577
SGTC_1244 0416-0015 52.5 µM 1.32821982284977 0.0878219310555469 no 316 0.0920527488196763 113 96201
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.32787424881017 0.0878785650267758 no 317 0.0921098265439713 115 6708784 An antioxidant flavonoid
SGTC_2710 st078562 53.7235 µM 1.32712997598969 0.0880006317496105 no 318 0.0922328454704049 124 17250908
SGTC_3276 9139060 49.47 µM 1.32477463869295 0.0883877591180318 no 319 0.0926229544376765 156 4870619
SGTC_3082 9117008 49.47 µM 1.32237012469711 0.0887842768469693 no 320 0.0930224660390464 117 41448529
SGTC_769 0302-0231 76 µM 1.3194380279524 0.0892695864752977 no 321 0.0935113577440441 148 571869 YER009W NTF2
SGTC_2885 9057732 51.95 µM 1.31596819843746 0.0898464461902666 no 322 0.094092358367262 137 6471414
SGTC_1280 0880-0253 10.1 µM 1.31513604878946 0.0899852022145076 no 323 0.0942320915942023 125 6836607
SGTC_2399 5884133 200 µM 1.31504320977096 0.0900006924391511 no 324 0.0942476904584958 131 722445
SGTC_1940 st075990 51.1 µM 1.31266347124101 0.0903984293162655 no 325 0.0946481858410509 121 1084979
SGTC_1037 k284-1091 78.7 µM 1.31086678202666 0.0906995820389741 no 326 0.0949513876484712 121 3334711
SGTC_1370 2001-0092 44.6 µM 1.3097222778345 0.0908918063679919 no 327 0.0951449021456722 133 790957
SGTC_2771 fluoxetine 41.05 µM 1.29711291293518 0.0930296462995843 no 328 0.0972961695668893 107 3386 A selective serotonin reuptake inhibitor.
SGTC_386 1509-0011 3.07 µM 1.29572367266693 0.0932674377432276 no 329 0.0975353512954833 118 3107280
SGTC_2851 9015922 71.43 µM 1.29361420769878 0.0936293657753824 no 330 0.0978993562156703 140 2996893
SGTC_1131 3454-3128 32.3 µM 1.29069535344059 0.0941318722627985 no 331 0.098404668264529 126 710982
SGTC_2153 5569715 200 µM 1.2902943964404 0.0942010556824963 no 332 0.0984742308703472 139 2054701
SGTC_661 1304-0007 33.6 µM 1.28995595253391 0.0942594819207255 no 333 0.0985329760060863 134 3117130
SGTC_1442 4112-3290 3 µM 1.28868386137455 0.0944793245597907 no 334 0.098754007679026 119 704353
SGTC_2449 5812982 45.77 µM 1.28614134726593 0.0949198540171616 no 335 0.0991968681311868 104 776185
SGTC_2332 7982454 138.89 µM 1.28563330627346 0.0950080610023627 no 336 0.0992855335993814 142 2981748
SGTC_1856 st057054 55.7 µM 1.28528761887448 0.0950681143770065 no 337 0.0993458975489398 137 1266018
SGTC_898 1000-0849 28.3 µM 1.28452935303913 0.0951999394612078 no 338 0.0994783999284969 154 6751807
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.28147966938476 0.0957314886997576 no 339 0.100012618237418 110 17037758
SGTC_1546 5-methoxyflavanone 78.7 µM 1.27926455565578 0.0961189420300585 no 340 0.100401954831667 113 147795
SGTC_283 0987-0079 11.7 µM 1.278993987912 0.0961663468839137 no 341 0.100449586513654 106 411556
SGTC_1911 st060208 74.3 µM 1.27715067944568 0.0964897614424217 no 342 0.10077452777346 146 688783
SGTC_1207 2099-0101 141 µM 1.27531287424692 0.0968130052861513 no 343 0.101099261353694 135 5837381
SGTC_2635 hydroquinidine 100 µM 1.27430070428317 0.0969913708272325 no 344 0.10127843350855 100 442912 An experimental heart treatment.
SGTC_3104 9120930 49.47 µM 1.27396648710243 0.0970503198380381 no 345 0.101337646696308 131 17014836
SGTC_3212 9128307 49.47 µM 1.27312617521939 0.09719864967944 no 346 0.10148663599292 116 27243542
SGTC_3227 9130768 49.47 µM 1.27133440638507 0.0975154838366898 no 347 0.101804853514681 114 17720899
SGTC_2440 5628896 157.78 µM 1.27075840413201 0.0976174976370328 no 348 0.101907305429562 121 5522048
SGTC_1902 st060212 70.5 µM 1.26458322704654 0.0987160824002824 no 349 0.103010384409957 128 688944
SGTC_850 0388-0143 75.9 µM 1.26405176813052 0.0988110519247102 no 350 0.103105723318637 125 67273
SGTC_2984 9022109 38.96 µM 1.26067751091495 0.0994155779493813 no 351 0.103712529844296 143 6459207
SGTC_2184 6075246 200 µM 1.25862211719699 0.0997851412047092 no 352 0.104083427232197 118 2267320
SGTC_248 streptozotocin 5.23457 mM 1.25447598460717 0.100533674889122 no 353 0.10483452467603 150 5300 DNA alkylating agent.
SGTC_1905 st060207 84.5 µM 1.25424767810088 0.100575011522985 no 354 0.10487599751449 147 1948547
SGTC_1393 3470-5649 58.2 µM 1.25184111983527 0.101011491619063 no 355 0.105313881661873 101 4108395
SGTC_36 0335-0881 14.2 µM 1.24973753639977 0.101394150448811 no 356 0.105697720267553 159 23828853
SGTC_2917 7979103 53.79 µM 1.24861575894736 0.101598642030099 no 357 0.1059028228108 118 2980565
SGTC_1122 capsaicin 818.572 nM 1.24721093584164 0.101855154036684 no 358 0.106160082058342 136 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2326 6164455 177.58 µM 1.24458779893839 0.102335383859009 no 359 0.106641653782604 146 2888790
SGTC_1966 st070145 16.1 µM 1.24152969196622 0.102897322015251 no 360 0.10720506824439 151 3748532
SGTC_2195 6536160 144.242 µM 1.24127964360769 0.102943368255191 no 361 0.107251230986591 109 3834386
SGTC_872 0588-0139 234 µM 1.2410557650573 0.102984608042153 no 362 0.107292574541884 118 2047100
SGTC_1209 2323-2347 50.3 µM 1.23814990395364 0.103520974457157 no 363 0.107830241380103 126 5412760
SGTC_2166 5933061 31.504 µM 1.22864391357206 0.105289757409592 no 364 0.10960267163201 128 2877375
SGTC_2966 9084041 48.03 µM 1.22298957721869 0.106352177960612 no 365 0.110666816500956 126 17741380
SGTC_2250 alverine citrate 130 µM 1.2207128210935 0.106782147623945 no 366 0.111097385829831 156 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2929 9013348 24.6 µM 1.22055539131696 0.106811924831858 no 367 0.111127202485495 119 2995952
SGTC_2387 9077560 195.08 µM 1.21944921801749 0.107021322020937 no 368 0.111336869481772 126 5303272
SGTC_725 1497-0963 19 µM 1.21711281049872 0.107464573795554 no 369 0.111780648637794 133 3549977
SGTC_985 1493-0307 8.71 µM 1.21645147213552 0.10759027959672 no 370 0.111906493222466 140 3278274
SGTC_521 r062-0005 13.8 µM 1.21415795569088 0.108027047181814 no 371 0.112343706131125 124 2832033
SGTC_1073 triclabendazole 3.09 µM 1.21391993621241 0.108072447620584 no 372 0.112389149581288 140 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1747 st037496 66.6 µM 1.21354711803261 0.108143587512529 no 373 0.11246035563076 167 723305
SGTC_675 1309-0189 238 µM 1.21016102404918 0.108791254282354 no 374 0.113108555354616 126 4246530
SGTC_2622 2-methoxyxanthone 59.94 µM 1.20949671069124 0.108918645770604 no 375 0.113236037012424 141 71034 A hepatoprotective.
SGTC_2979 9012552 45.46 µM 1.20812663246298 0.109181716233877 no 376 0.113499278494134 147 17100905
SGTC_647 0140-0236 81 µM 1.19930348950428 0.110886800689529 no 377 0.115204979374858 135 990837
SGTC_979 1426-2828 121 µM 1.19698171251485 0.11133864086639 no 378 0.115656841379449 148 747872
SGTC_574 1315-0397 40 µM 1.19591008651631 0.111547633550927 no 379 0.115865824292108 172 6794277
SGTC_374 0880-0231 82.3 µM 1.19111900289384 0.112485442266037 no 380 0.116803435412626 155 6833587
SGTC_1430 4049-0248 69.1 µM 1.19104473807743 0.112500023087237 no 381 0.116818011185542 145 22774488
SGTC_1724 st037281 8.293 µM 1.18911148296439 0.112880064868762 no 382 0.117197900155359 150 574124 YDL195W SEC31
SGTC_753 1322-0200 289 µM 1.18871399028741 0.112958317948953 no 383 0.117276116703098 124 5403907
SGTC_2281 7943571 200 µM 1.18682634242553 0.113330461543311 no 384 0.117648062954821 156 1244024
SGTC_2751 anetholtrithion 17.25 µM 1.18257327732271 0.114172142297185 no 385 0.118489154203081 128 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2124 5246320 200 µM 1.1804814287295 0.114587748175759 no 386 0.118904396228661 161 579342
SGTC_2833 9001315 45.46 µM 1.18033082725751 0.114617710984331 no 387 0.118934330955618 144 2989378
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.17592258515366 0.115497220993559 no 388 0.119812906403069 154 66535 A nucleotide analog.
SGTC_3109 9122853 49.47 µM 1.17545063488119 0.115591665521144 no 389 0.119907237942574 174 1234709
SGTC_2404 5161160 200 µM 1.17291042751056 0.116100942588482 no 390 0.120415863756901 187 2831543
SGTC_155 k072-0202 43.6 µM 1.1725753414304 0.11616824151025 no 391 0.120483071333387 163 5857737
SGTC_2202 7226349 200 µM 1.17256601980736 0.116170114067233 no 392 0.120484941331134 121 844334
SGTC_3154 9100113 49.47 µM 1.17132670141422 0.116419263024375 no 393 0.120733741285921 146 25237525
SGTC_2624 nerol 100 µM 1.17060020665374 0.116565491523433 no 394 0.120879757115937 157 637566 A natural product oil.
SGTC_2945 9067681 61.76 µM 1.16581110905718 0.117532698615315 no 395 0.121845412345461 177 16456930
SGTC_1708 st033234 31.827 µM 1.16572518493757 0.117550103597955 no 396 0.121862787101619 146 674664
SGTC_27 0485-0001 32.618 µM 1.1594119117396 0.11883393024011 no 397 0.12314416183207 147 2054479
SGTC_2259 7964009 200 µM 1.15748875074589 0.119226972557057 no 398 0.123536366335699 124 313134
SGTC_2429 5902844 64.44 µM 1.15621420520318 0.119487960370685 no 399 0.123796775414773 162 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2905 7799065 20.05 µM 1.15590074395298 0.119552209321534 no 400 0.123860879159001 143 1296806
SGTC_2063 5246145 200 µM 1.15538925077224 0.119657100437872 no 401 0.123965530895685 163 711240
SGTC_2732 terfenadine 20 µM 1.15472030567771 0.119794377901992 no 402 0.124102490728057 168 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1578 josamycin 24.2 µM 1.15278531473673 0.120192091839496 no 403 0.124499256721097 147 5282165 A P450 substrate.
SGTC_3239 9133757 49.47 µM 1.15237056497607 0.12027745956684 no 404 0.124584415616359 143 17036923
SGTC_3141 9094609 49.47 µM 1.15185827953197 0.120382961966828 no 405 0.124689657318199 185 25236309 YDL196W YDL196W
SGTC_453 enantio-paf c16 10 µM 1.15122180157634 0.120514131919118 no 406 0.124820499126524 179 13871343 A lipid and platelet activating factor
SGTC_1054 3429-0080 167 µM 1.14831362606286 0.121114750088836 no 407 0.125419557997036 159 1162877
SGTC_3341 9147222 25.867 µM 1.14770987957973 0.121239703821044 no 408 0.125544175660697 158 1939759
SGTC_2090 5301565 104.445 µM 1.14537873136117 0.121723018116708 no 409 0.126026152392519 160 2056344
SGTC_1864 st057645 30.4 µM 1.14510995272393 0.121778830608948 no 410 0.126081806578638 165 688666
SGTC_2721 ifenprodil 61.44 µM 1.14358392296845 0.122096054986497 no 411 0.12639811610577 147 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1711 st032263 62.8 µM 1.1425650957221 0.122308167081335 no 412 0.126609602210872 152 3958979
SGTC_1839 st053978 48 µM 1.14209709347181 0.122405688241931 no 413 0.126706831734751 136 3788398
SGTC_543 3844-1095 191 µM 1.14200255826314 0.122425393879814 no 414 0.126726478150325 191 4230703
SGTC_3115 9123671 49.47 µM 1.1413085219621 0.122570132254898 no 415 0.126870778523643 165 3286988
SGTC_3072 9116419 49.47 µM 1.13972516697731 0.122900783585831 no 416 0.127200409391068 147 17170162
SGTC_1654 st012436 41.8 µM 1.13903848601114 0.123044377138496 no 417 0.127343551198149 140 4323132
SGTC_3257 9139206 32.98 µM 1.13774339181168 0.123315517465067 no 418 0.127613824380769 154 4910041
SGTC_128 0906-2981 13.371 µM 1.13711795117947 0.123446609221158 no 419 0.127744490272206 168 6740226
SGTC_282 k297-0036 65.7 µM 1.13127801335636 0.124675366770405 no 420 0.128969047696406 158 5061378
SGTC_2897 9048598 12.99 µM 1.13081221156074 0.124773741052733 no 421 0.129067069521456 127 6467404
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.12730243727442 0.125516726615889 no 422 0.129807316137363 178 442882
SGTC_1010 4112-3296 15.2 µM 1.12677584306613 0.125628467380819 no 423 0.12991863326203 137 704384
SGTC_1330 1469-0054 61.8 µM 1.12677100084125 0.125629495199657 no 424 0.129919657169945 154 7102664
SGTC_2916 7875993 68.79 µM 1.12451117110362 0.126109810926971 no 425 0.130398117043474 156 1299250
SGTC_2031 5180455 200 µM 1.12344121678153 0.12633767045429 no 426 0.130625076517719 158 29949
SGTC_1446 4239-0190 62 µM 1.12315501604871 0.126398668915103 no 427 0.130685831893357 157 1340085
SGTC_31 0508-1974 57.237 µM 1.11965468119115 0.127146361844886 no 428 0.131430472055241 140 6810525
SGTC_325 2810-4341 181 µM 1.11947960440233 0.127183839960977 no 429 0.131467793602876 145 774970
SGTC_3298 9116858 71.43 µM 1.11825171779439 0.127446905623636 no 430 0.131729750785277 174 2506942
SGTC_1738 st035555 74 µM 1.11727942998661 0.127655479394996 no 431 0.131937433892855 168 5331140
SGTC_1382 3002-2117 298 µM 1.11465068051965 0.128220582551733 no 432 0.132500071680232 159 1497314
SGTC_1253 0550-0034 176 µM 1.11345580123498 0.128478019592078 no 433 0.132756360397709 162 5969915
SGTC_1990 st072050 59.8 µM 1.11245768573541 0.128693338670491 no 434 0.132970706952676 158 17233948
SGTC_469 w7 172 µM 1.11112487265205 0.128981250800651 no 435 0.133257301545284 138 45115570 A P450 inhibitor.
SGTC_3229 9132204 49.47 µM 1.1065174777477 0.129979972441878 no 436 0.13425130168785 131 17682924
SGTC_2157 5649910 96.377 µM 1.10550775543454 0.130199558047348 no 437 0.134469817888538 149 2858091
SGTC_972 1319-0219 195 µM 1.10537064595972 0.130229395202951 no 438 0.134499508867076 175 23903702
SGTC_1371 2421-0008 32.7 µM 1.10339123689565 0.130660672626265 no 439 0.134928650279549 187 2827552
SGTC_294 k038-0071 157 µM 1.10321115873908 0.130699957344171 no 440 0.134967738285249 173 24152826
SGTC_1850 st056238 17 µM 1.10209891594181 0.130942778197749 no 441 0.135209335323257 171 5393177
SGTC_2182 6325192 200 µM 1.09903410615717 0.131613488736047 no 442 0.135876594814645 159 736248
SGTC_3029 9088683 49.47 µM 1.09672796574403 0.132119730901112 no 443 0.136380163801343 144 25236615
SGTC_37 0566-0070 1.56 µM 1.09137855710127 0.13329919335863 no 444 0.137553171875456 153 1626686
SGTC_1046 2001-0062 216 µM 1.09024539777333 0.133549964543465 no 445 0.137802530212832 175 739778
SGTC_1356 1502-0781 85.8 µM 1.08770898430237 0.134112454890443 no 446 0.138361800121264 176 567702
SGTC_1648 st011736 69.8 µM 1.0874903769099 0.13416101065397 no 447 0.138410074566043 176 2855514
SGTC_3347 9188721 44.724 µM 1.08309083798233 0.135140777386065 no 448 0.139384052632311 180 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_254 nsc-64875 3.808 µM 1.08182846656096 0.13542280803643 no 449 0.139664377547079 137 56993
SGTC_794 k038-0031 316 µM 1.08149670003567 0.135496996000773 no 450 0.139738113903468 158 6624242
SGTC_3037 9091026 49.47 µM 1.07748434491616 0.136396423906752 no 451 0.140631970488715 169 25236398 YIL048W NEO1
SGTC_1702 st027038 51 µM 1.07669401830857 0.136574067516189 no 452 0.140808492787257 141 5521182
SGTC_2134 5324836 1.464 µM 1.07435771516669 0.137100128879936 no 453 0.141331193297875 158 699272
SGTC_1982 st072467 71.9 µM 1.07408495050211 0.137161636957249 no 454 0.141392304495724 172 3163533
SGTC_2556 citropten 84.59 µM 1.07365222603604 0.137259254430801 no 455 0.141489290412878 145 2775 A potential DNA crosslinker.
SGTC_2043 5101342 149 µM 1.071222343983 0.137808288044154 no 456 0.142034733591444 176 678451
SGTC_1552 6-methylflavone 10.6 µM 1.07033754014182 0.138008581760498 no 457 0.142233701311636 154 689013
SGTC_3000 9075062 71.4286 µM 1.06844288334804 0.138438144176571 no 458 0.14266039088972 155 17057871
SGTC_399 oxolinic acid 75 µM 1.06646734444915 0.138887013852436 no 459 0.143106216460979 166 4628 A DNA gyrase inhibitor.
SGTC_3156 9099931 49.47 µM 1.06212825107918 0.139876391387144 no 460 0.144088733193447 179 18111053
SGTC_2436 5633522 8.09 µM 1.06150769351958 0.140018278263977 no 461 0.144229619204236 174 5724242
SGTC_3006 9075424 71.4286 µM 1.05798887639754 0.14082468454969 no 462 0.145030256863131 188 7465181
SGTC_1366 1683-0113 21.9 µM 1.05688974958314 0.141077215689079 no 463 0.14528095356788 162 708623
SGTC_419 nsc-638432 893 µM 1.05649537193879 0.141167901193694 no 464 0.1453709770746 170 368090
SGTC_2303 7774051 200 µM 1.05531831539698 0.14143879544911 no 465 0.145639883642276 172 2953184
SGTC_2540 epiandrosterone 100 µM 1.05501181809561 0.141509392192251 no 466 0.145709959879939 181 441302 A steroid.
SGTC_1297 1068-0111 14.1 µM 1.05470556898211 0.141579955613115 no 467 0.145780002008858 172 767057
SGTC_1226 3909-7979 35.4 µM 1.05418866443905 0.141699110605895 no 468 0.145898274395811 187 6615510
SGTC_2285 7945142 200 µM 1.05199780044119 0.142204894700356 no 469 0.146400279393435 170 2970608
SGTC_355 1311-2252 105 µM 1.05130826715704 0.142364333197323 no 470 0.14655851567772 167 5338538
SGTC_698 k064-0052 127 µM 1.04707204573567 0.14334651384739 no 471 0.147533175516347 180 5088751
SGTC_4 0960-0234 25.671 µM 1.04532824363197 0.143752145919935 no 472 0.147935644177277 169 6821112
SGTC_759 3486-0358 89.3 µM 1.04512197337924 0.143800178358939 no 473 0.147983299814063 188 875103
SGTC_2018 5133068 143 µM 1.044621155293 0.143916844760541 no 474 0.148099049051925 176 785362
SGTC_3079 9117512 49.47 µM 1.0439985949111 0.144061960221561 no 475 0.148243019856543 207 7185044
SGTC_1287 0971-0001 34.6 µM 1.04290895787403 0.144316186143346 no 476 0.148495230217682 172 4665869
SGTC_12 0849-0099 9.267 µM 1.04042176905632 0.144897610624722 no 477 0.149071996130286 177 6071388
SGTC_1502 4534-4282 27.7 µM 1.0402748109465 0.144932013965652 no 478 0.149106121693698 174 3278949
SGTC_2964 9083345 53.42 µM 1.03919555630165 0.145184839250982 no 479 0.149356898363896 186 17741579
SGTC_2842 9000675 19.48 µM 1.03877683401358 0.145283008643168 no 480 0.149454268856465 185 2989072
SGTC_1904 st060225 78 µM 1.03858882898753 0.14532710092417 no 481 0.149498001689652 165 66595
SGTC_2601 securinine 100 µM 1.03676535359113 0.145755222469483 no 482 0.14992261297266 221 442872 A GABA receptor antagonist.
SGTC_1077 5-fluorocytosine 377 nM 1.0358725298381 0.145965151424357 no 483 0.150130807358615 202 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.03298412338842 0.146645691414769 no 484 0.150805664305065 196 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3089 9117425 49.47 µM 1.02964711061415 0.147434574853194 no 485 0.151587845837438 161 9401657
SGTC_2680 butyl paraben 22.24 µM 1.02742160109432 0.147962272128906 no 486 0.152110992151539 201 7184 An antifungal and steroid mimetic.
SGTC_1794 st048918 76.9 µM 1.02739175670827 0.147969357201346 no 487 0.152118015752016 140 672303
SGTC_2183 6420625 130.508 µM 1.02696961263396 0.148069598743496 no 488 0.152217386526564 199 2897619
SGTC_3145 9085516 49.47 µM 1.02218287605732 0.149209427310792 no 489 0.153347176955101 175 25236195
SGTC_319 1348-1596 45.5 µM 1.01825042246781 0.150150204921682 no 490 0.154279481308184 187 5380505
SGTC_2551 apiole 73.87 µM 1.01732716936176 0.150371650574637 no 491 0.154498907927773 154 10659 A possible DNA adduct former.
SGTC_3171 9103192 49.47 µM 1.01677596722944 0.150503962122383 no 492 0.154630008677454 184 13018434
SGTC_1130 3454-2858 15.9 µM 1.01499348207036 0.150932363807214 no 493 0.155054467250291 211 715628 YIL048W NEO1
SGTC_2328 6201408 200 µM 1.01485767054665 0.15096503793099 no 494 0.155086839208919 196 2890418
SGTC_830 4076-0286 57.8 µM 1.01462914956394 0.151020027121492 no 495 0.155141319412949 181 6866659
SGTC_276 colchicine 750 µM 1.01102982176518 0.151887894556896 no 496 0.156001078382208 188 2833 A microtubule depolymerizer.
SGTC_3267 9137951 49.47 µM 1.00759017554887 0.152720349906567 no 497 0.156825623647103 194 16643986
SGTC_281 1672-3440 14.9 µM 1.00647285681325 0.152991410802245 no 498 0.15709408107292 186 6833000
SGTC_371 0195-0006 7.36 µM 1.0056332867774 0.15319529976655 no 499 0.15729600276802 173 3928593
SGTC_2504 purpurogallin 52.29 µM 1.00480003118483 0.153397833232012 no 500 0.157496574436223 171 5281571 An antioxidant.
SGTC_1062 mesoridazine 14.2 µM 1.0045070205171 0.153469095368806 no 501 0.157567144507165 164 4078 A neuroleptic.
SGTC_1187 1391-0724 117 µM 1.00419336761372 0.153545402128806 no 502 0.15764270917233 174 6997986
SGTC_2894 9048625 32.47 µM 1.00334932887172 0.153750868083654 no 503 0.157846171609444 199 4092861
SGTC_2652 actinonin 100 µM 1.00252862185753 0.153950828801597 no 504 0.158044175039486 196 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1934 st074720 32.6 µM 1.00202232205708 0.154074271731874 no 505 0.158166406002058 171 17250992
SGTC_1341 1486-1360 280 µM 1.00164853734321 0.154165447646951 no 506 0.158256684954914 198 3976547
SGTC_1735 st034310 56.75 µM 0.998449850202748 0.154947150721662 no 507 0.159030635524412 191 871153
SGTC_339 3091-4833 71.4 µM 0.998002480779602 0.155056688267766 no 508 0.159139077845778 200 3240077
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.996262385817018 0.155483233299537 no 509 0.159561337275796 169 803109
SGTC_2712 st079126 47.7 µM 0.996106098871902 0.155521581370501 no 510 0.159599298440431 182 3152970
SGTC_1277 0873-0036 22 µM 0.994958856480409 0.15580327081449 no 511 0.159878137684757 186 5965735
SGTC_1041 0206-0046 107 µM 0.990112610978353 0.156996908934516 no 512 0.161059540008406 186 50494
SGTC_2361 9034121 116 µM 0.988958804106089 0.157281977685676 no 513 0.161341648885496 210 6496917
SGTC_2724 maprotiline 69.64 µM 0.986449574568209 0.157903102044577 no 514 0.161956274118942 189 4011 A tricyclic antidepressant.
SGTC_1163 k060-0048 49.9 µM 0.984278308147856 0.1584418665266 no 515 0.162489346008759 181 6809982
SGTC_2001 4023502 57.655 µM 0.982947985813363 0.158772559425426 no 516 0.162816519505595 166 108941 YCR052W RSC6
SGTC_2132 5317594 122.667 µM 0.982811377978901 0.158806543139592 no 517 0.162850140460519 202 794577
SGTC_641 4092-0595 30 µM 0.982096176165047 0.158984540578899 no 518 0.163026234561006 187 786260
SGTC_1808 st050063 61.5 µM 0.981529053566359 0.159125777369252 no 519 0.163165957152111 188 4011993
SGTC_1025 k007-0731 70 µM 0.98144338554815 0.15914711936331 no 520 0.163187070035473 167 6256118
SGTC_410 α-linolenic acid 100 µM 0.980859663771411 0.159292588614862 no 521 0.163330975526056 198 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2812 7970281 58.44 µM 0.979174085281685 0.159713140078082 no 522 0.163746985412781 194 2233435
SGTC_692 k241-0027 77.8 µM 0.978833173361103 0.159798285773611 no 523 0.163831207866756 183 3600480
SGTC_2729 fluphenazine 10.66 µM 0.977901922187089 0.160031025121032 no 524 0.164061417183155 208 3372 An atypical antipsychotic.
SGTC_463 ikarugamyin 104 µM 0.977768055245739 0.160064499511225 no 525 0.164094526912126 168 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1347 1493-0251 600 nM 0.977320574324091 0.16017642855828 no 526 0.164205235224529 188 3986378
SGTC_2173 5763948 167 µM 0.976358644384078 0.160417210651264 no 527 0.164443383925941 195 2867177
SGTC_111 0083-0039 52.457 µM 0.975001500306943 0.16075732138008 no 528 0.164779757876368 154 759313
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.974616932491735 0.160853782581048 no 529 0.164875155637327 189 4213774
SGTC_1301 naphtanilide LB 4.81 µM 0.974133784749833 0.160975024146612 no 530 0.164995058302165 207 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2558 carylophyllene oxide 100 µM 0.971186541111601 0.161715899642979 no 531 0.165727697389822 200 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_617 3770-0098 35 µM 0.970819087756809 0.161808425303463 no 532 0.16581918784195 188 5962639
SGTC_3268 9137683 49.47 µM 0.970275258540231 0.16194542613398 no 533 0.165954653182172 244 1953228
SGTC_1101 ebselen 5.29 µM 0.968010495653237 0.162516774939419 no 534 0.166519563982117 207 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.965714863333538 0.163097248345424 no 535 0.16709343997752 200 7104
SGTC_2872 9044037 25.97 µM 0.965375765454953 0.163183106696805 no 536 0.167178317676301 184 6465195
SGTC_2581 avocatin a 64 µM 0.96410128299005 0.163506063622453 no 537 0.167497574770894 181 6710728 A skin care supplement.
SGTC_78 0336-0123 156.75 µM 0.964053239971121 0.163518245952208 no 538 0.167509617195767 176 6765896
SGTC_1820 st053765 18.6 µM 0.963905389990884 0.163555740158923 no 539 0.167546680653576 199 3690829
SGTC_2779 methotrexate 400 µM 0.963417580799693 0.163679486353303 no 540 0.167669003528495 204 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_185 k048-0037 25.491 µM 0.96007113571957 0.164530042265266 no 541 0.168509707176788 176 6827589
SGTC_2219 9098279 200 µM 0.95988202340076 0.164578193738093 no 542 0.168557297291616 154 902349
SGTC_963 1269-2853 151 µM 0.959588596085503 0.164652923802231 no 543 0.168631155377568 175 3668223
SGTC_3264 9137442 49.47 µM 0.955651184745865 0.165657830147569 no 544 0.169624246328478 193 17015726
SGTC_2597 laccaic acid a 100 µM 0.951202227445738 0.166798055236206 no 545 0.170750863967209 192 5491415 A textile dye.
SGTC_760 0568-0725 82.9 µM 0.950846968131104 0.166889322583564 no 546 0.170841032955737 210 3916171
SGTC_2961 9083290 32.55 µM 0.950773487149559 0.166908204121735 no 547 0.170859687094528 195 17741490
SGTC_133 0724-0033 378.92 µM 0.95015069809 0.16706829018227 no 548 0.171017842834527 199 280309
SGTC_3258 9138477 49.47 µM 0.949954283109458 0.167118798593402 no 549 0.171067741350778 205 4970355
SGTC_1420 4'-methoxyflavone 42 µM 0.94968289908783 0.167188601604697 no 550 0.17113670080144 186 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_324 1315-0088 19.6 µM 0.949648234896752 0.167197518976573 no 551 0.171145510351076 213 6787421
SGTC_569 4130-2812 160 µM 0.949319403684568 0.167282126138136 no 552 0.171229093864353 181 743552
SGTC_1042 0350-0096 82 µM 0.94861827002482 0.167462617592292 no 553 0.171407397707152 193 3122515
SGTC_1373 2887-0003 58.5 µM 0.948479539255612 0.167498345644593 no 554 0.171442692099601 210 776948
SGTC_573 3702-0553 84.7 µM 0.948266136771894 0.167553313876008 no 555 0.171496992734769 203 1222756
SGTC_3279 9140807 49.47 µM 0.947373408810664 0.167783388794487 no 556 0.171724268067579 201 45595718
SGTC_1819 st053448 58.6 µM 0.946558082804724 0.167993693230641 no 557 0.171932006020274 219 2857616
SGTC_2007 4011539 71.82 µM 0.945286297060342 0.168322075032331 no 558 0.172256366132076 165 45595301
SGTC_1817 st052116 64.4 µM 0.941576112855279 0.169282421461991 no 559 0.173204852094806 167 4361398
SGTC_2962 9082311 13.18 µM 0.933329284821878 0.171429606002026 no 560 0.175324989685238 207 16459453
SGTC_840 0245-0196 390 µM 0.931559139809801 0.171892748998366 no 561 0.175782203933288 193 3827528
SGTC_2243 6634756 200 µM 0.931203720966476 0.171985837464448 no 562 0.175874096736574 157 885676
SGTC_514 4466-0038 2.65 nM 0.928956935850717 0.17257504206977 no 563 0.176455702226638 208 5722064
SGTC_220 paclitaxel 373.376 µM 0.926502464088757 0.173220180386147 no 564 0.177092458574235 179 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_431 k089-0097 107 µM 0.919233086951743 0.175139874082963 no 565 0.17898683417653 216 5499420
SGTC_1790 st045711 43.5 µM 0.918099347439796 0.175440483354659 no 566 0.179283428235706 166 585119
SGTC_129 0088-0017 176.636 µM 0.916796963724122 0.17578621178635 no 567 0.179624521993272 185 182446
SGTC_3 0833-0587 95.581 µM 0.914591671455177 0.176372608020648 no 568 0.18020301630848 200 5382644
SGTC_1494 4358-1428 177 µM 0.914311634365354 0.176447159484933 no 569 0.180276559480747 183 1564571
SGTC_200 k038-0079 37.545 µM 0.913282585745758 0.176721283954769 no 570 0.180546969356005 221 3436683
SGTC_566 0958-0068 16.5 µM 0.912745164021174 0.176864552714983 no 571 0.180688292266542 222 6815365
SGTC_1116 jasmonic acid 1.58368 µM 0.91172191413247 0.177137539032512 no 572 0.180957562497436 208 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2470 5664817 21.68 µM 0.908683208210126 0.177949783765269 no 573 0.181758685158256 199 2859561
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.908194490737906 0.178080636634296 no 574 0.181887737161561 212 165506
SGTC_1920 st075728 45.7 µM 0.90795394345496 0.178145064832953 no 575 0.181951277740957 195 3400306
SGTC_2826 7992541 19.48 µM 0.900141992731819 0.180245400628336 no 576 0.184022345589411 254 2985066
SGTC_3207 9114163 49.47 µM 0.898089946793192 0.180799684581461 no 577 0.184568799114463 233 849233
SGTC_2552 juarezic acid 87.02 µM 0.897446992842197 0.180973574306892 no 578 0.184740223189351 189 1549512
SGTC_340 k038-0059 454 µM 0.896274645339199 0.181290910504207 no 579 0.185053048593797 220 23733424
SGTC_513 4245-1575 41.7 µM 0.894882389989033 0.181668224657864 no 580 0.185424980680671 225 719745
SGTC_776 4476-4378 112 µM 0.893551743875251 0.182029301016758 no 581 0.185780887614094 217 2892008
SGTC_144 4161-2749 112.381 µM 0.893182471099657 0.182129584207188 no 582 0.185879731794161 226 797501 YMR168C CEP3
SGTC_2822 7994718 71.43 µM 0.892040617657967 0.182439895121922 no 583 0.186185580886612 239 1018011
SGTC_599 1935-0052 86.5 µM 0.891295996027817 0.182642431843188 no 584 0.186385198077671 186 9557311
SGTC_1409 3909-8004 61.9 µM 0.891054482584154 0.18270815352529 no 585 0.186449971149034 194 2119279
SGTC_201 4262-0159 12.803 µM 0.889740940488032 0.183065858758556 no 586 0.186802502679709 201 1341029
SGTC_678 1218-2179 85.9 µM 0.886450578077147 0.1839638101769 no 587 0.187687387354577 227 6820081 YOR116C RPO31
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.885065954293928 0.184342497357011 no 588 0.188060530211811 197 1241132 A phosphatase inhibitor.
SGTC_726 3448-4391 34.2 µM 0.884560323656556 0.184480905434237 no 589 0.188196906890862 220 1356692
SGTC_1680 diphenhydramine 100 µM 0.883288588809211 0.184829307588422 no 590 0.188540183821279 213 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2817 7995342 71.43 µM 0.881767812973922 0.185246473093107 no 591 0.188951190446602 203 18879975
SGTC_3224 9130643 49.47 µM 0.880664087167165 0.185549603061704 no 592 0.189249830051819 225 17644395
SGTC_191 3914-0123 66.505 µM 0.877770362438048 0.186345803126287 no 593 0.1900341756273 221 3144412
SGTC_3191 9110352 49.47 µM 0.87605671283791 0.186818305250828 no 594 0.190499601762888 211 17122424
SGTC_121 0557-0495 61.343 µM 0.874726709995754 0.187185535608106 no 595 0.190861311653556 240 3104427
SGTC_1268 0828-0275 2.46 µM 0.873919509585242 0.187408631232039 no 596 0.191081044612886 217 745337
SGTC_1841 st054148 70 µM 0.873799255308559 0.187441881404397 no 597 0.191113793036592 213 675442
SGTC_992 3909-8734 162 µM 0.87277871586241 0.187724206166509 no 598 0.191391851464954 198 4288319
SGTC_143 4032-1194 15.74 µM 0.872535225132512 0.187791604884931 no 599 0.191458230100022 222 1806963
SGTC_172 1112-0046 2.638 µM 0.872241738060998 0.187872862550542 no 600 0.191538257111685 200 2802135 YIL048W NEO1
SGTC_2150 5556613 200 µM 0.871005045812641 0.188215503553907 no 601 0.191875699007695 222 743190
SGTC_1811 st050069 61.5 µM 0.869777657965425 0.188555947647168 no 602 0.192210961702297 216 3877702
SGTC_1136 pergolide 1.05886 µM 0.867023341818992 0.189321301144909 no 603 0.192964610250599 229 47811 A dopamine receptor agonist.
SGTC_76 0433-0009 400.328 µM 0.865554923657839 0.189730117131891 no 604 0.193367142023714 209 2841569
SGTC_2495 cafestol 54.53 µM 0.865060052768313 0.18986801423821 no 605 0.193502914408039 234 16667697 An anti-infammatory.
SGTC_3099 9120367 49.47 µM 0.859718034830002 0.191360502074419 no 606 0.194972245419979 245 24824940
SGTC_764 1951-2361 146 µM 0.856975330185673 0.192129562395279 no 607 0.195729259368708 224 5438930
SGTC_1358 1509-0022 2.48 µM 0.856043078968498 0.192391397678955 no 608 0.195986975773231 239 3258434
SGTC_2947 9072639 7.68 µM 0.855485254527576 0.192548174459057 no 609 0.196141282075016 229 16488146
SGTC_610 4215-0184 155 µM 0.852906510462605 0.193273945933162 no 610 0.196855575510457 218 5605015
SGTC_1795 st049545 62.3 µM 0.848994239379873 0.19437821302249 no 611 0.197942248869708 194 5291882
SGTC_1386 3228-0095 33.8 µM 0.848798352682962 0.194433604264068 no 612 0.197996753487093 211 870181
SGTC_160 3453-0671 289.699 µM 0.848129619730292 0.1946227754938 no 613 0.198182893788905 232 5322268
SGTC_3325 9138760 55.175 µM 0.846003849261914 0.195224857046541 no 614 0.198775298465251 221 43844959
SGTC_1032 k061-1018 98.7 µM 0.845556914763024 0.195351586067369 no 615 0.198899984803044 199 4005393
SGTC_1008 4106-0037 6 µM 0.845248604865526 0.195439036973824 no 616 0.198986024948104 246 2905394
SGTC_429 1112-0049 25.5 µM 0.844825595017281 0.195559060762069 no 617 0.199104110936606 216 2836170
SGTC_814 3342-0569 96 µM 0.843681929598075 0.195883785632767 no 618 0.199423583982542 225 4346283
SGTC_1741 st038134 10.228 µM 0.843064127082253 0.196059336462509 no 619 0.199596290078491 196 1272587
SGTC_2529 gangaleoidin 93.61 µM 0.843062819624586 0.196059708082519 no 620 0.199596655672435 231 4565183
SGTC_2138 5575593 77.673 µM 0.842664614418382 0.196172910229222 no 621 0.199708021364352 224 762213
SGTC_962 1254-0300 21.5 µM 0.839621520887462 0.197039311828077 no 622 0.200560314402901 205 7340576
SGTC_695 3505-6186 243 µM 0.839105814255875 0.197186368234608 no 623 0.200704966834379 236 1819379
SGTC_2903 5923464 63.88 µM 0.83823978199797 0.197433471141403 no 624 0.200948024223225 232 2876576
SGTC_2056 5235370 200 µM 0.838219581652976 0.197439237091251 no 625 0.200953695683622 210 5511916
SGTC_1631 benzylvanillin 81.9 µM 0.836358284282912 0.197970959292312 no 626 0.201476686591497 207 75506
SGTC_404 fumagillin 50 µM 0.836320966468792 0.197981628816606 no 627 0.201487180556028 246 12015870 A methionine aminopeptidase binder.
SGTC_393 acivicin 6.25 µM 0.834805985470816 0.198415069732588 no 628 0.201913477626609 231 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2012 4023501 200 µM 0.829719297623514 0.199874570689997 no 629 0.203348754084627 247 3477460
SGTC_13 0199-0087 65 µM 0.827798497887892 0.200427372407056 no 630 0.203892312766259 232 4589825
SGTC_2472 5377652 49.4 µM 0.827345430738715 0.200557897814959 no 631 0.20402065034584 237 1610903
SGTC_161 4065-0411 162.148 µM 0.826577065437618 0.200779375017964 no 632 0.204238410506923 229 1906281 YLR208W SEC13
SGTC_1139 k015-0024 46.9 µM 0.823214374353175 0.201750378468562 no 633 0.205193048011697 238 2766652
SGTC_1047 2043-3044 82 µM 0.821991246000352 0.202104262709638 no 634 0.205540939575979 261 669592
SGTC_2047 4141938 200 µM 0.818627806821777 0.203079310207628 no 635 0.20649939853877 252 3807862
SGTC_1945 st075991 56.6 µM 0.81849060623528 0.203119143636603 no 636 0.206538551884157 211 1084980
SGTC_346 4513-0042 7.16 µM 0.817080240172091 0.203528885399545 no 637 0.206941287178832 221 2827372
SGTC_1965 Pectolinarigenin 58.4 µM 0.816752809647217 0.203624081495322 no 638 0.207034852616139 243 5320438 An anti-inflammatory.
SGTC_978 1416-0512 87.4 µM 0.816030863748784 0.203834071509772 no 639 0.207241241845147 233 6814003
SGTC_2389 9091542 195.52 µM 0.815246011512582 0.204062505255465 no 640 0.207465752663272 231 3626624 YOL127W RPL25
SGTC_358 0075-0058 9.45 µM 0.815150843753917 0.204090214498622 no 641 0.207492985635227 254 1069125
SGTC_755 1995-0008 37.3 µM 0.812909281601254 0.204743520312682 no 642 0.20813503629897 208 689533
SGTC_2719 novobiocin 32.65 µM 0.812891276260607 0.204748773020343 no 643 0.208140198311102 245 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1158 4092-0494 91.8 µM 0.812816068885031 0.204770714174857 no 644 0.208161760585366 219 1148199
SGTC_2792 7535235 81.82 µM 0.812247638551018 0.204936594433406 no 645 0.208324774606729 222 1281891
SGTC_2408 sulbentine 18.36 µM 0.810742524052031 0.205376205035161 no 646 0.20875677372812 225 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2942 9052777 62.25 µM 0.810396614478183 0.205477316654113 no 647 0.208856131515122 267 6469503
SGTC_2160 5660466 132.927 µM 0.810115746250721 0.205559438004814 no 648 0.208936827558451 234 2859134
SGTC_3311 9131146 2.8755 µM 0.810111046867378 0.20556081219461 no 649 0.208938177891015 243 4900406 YPR165W RHO1
SGTC_3005 9076496 71.4286 µM 0.809588945991345 0.205713518461589 no 650 0.209088231672466 230 21368410
SGTC_1527 coumarin 137 µM 0.809375913787826 0.20577584635389 no 651 0.209149476163832 247 323 A hepatotoxic, DNA x-linker.
SGTC_1692 fluoroquinolonic acid 71 µM 0.809212166042842 0.205823762462946 no 652 0.209196559076566 227 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1642 st009582 77.7 µM 0.807447717273555 0.206340497950875 no 653 0.209704292413831 253 6739311
SGTC_2990 9074105 71.4286 µM 0.806740082394734 0.206547951313563 no 654 0.209908123049301 241 6502001
SGTC_1233 0325-0408 14.2 µM 0.80667254492596 0.206567757352079 no 655 0.209927582959562 227 12874
SGTC_649 1123-0311 367 µM 0.806074016672558 0.206743330905089 no 656 0.210100086240891 237 693629 YIL048W NEO1
SGTC_708 3448-5400 146 µM 0.80490950200924 0.207085185193869 no 657 0.210435952365183 248 3462195
SGTC_804 1595-0054 20.9 µM 0.804602615443414 0.207175330291792 no 658 0.210524516191666 235 761523 Stimulates phospholipase C.
SGTC_1222 0366-0074 1.18 µM 0.804327200959249 0.207256250514222 no 659 0.21060401617003 241 286520
SGTC_2674 ligustilide 100 µM 0.80303448374192 0.207636316692295 no 660 0.210977401762648 237 5319022 A signalling regulator.
SGTC_921 1561-0023 372 µM 0.800803920374333 0.20829308239346 no 661 0.211622584540547 237 24050882
SGTC_3220 9131269 49.47 µM 0.798783331530103 0.208889079916395 no 662 0.212208028660379 261 17722206
SGTC_2023 5144124 124 µM 0.798032380130099 0.20911083808957 no 663 0.212425849925582 245 2830192
SGTC_3102 9121669 49.47 µM 0.797206834048891 0.209354784181583 no 664 0.21266545882818 262 41905072
SGTC_1312 1218-2183 165 µM 0.794840973938518 0.210054814940861 no 665 0.213353006571071 243 6744073
SGTC_2094 5332512 191.667 µM 0.794839597910805 0.210055222491371 no 666 0.213353406838175 246 755774
SGTC_1285 0929-0069 65.5 µM 0.794021974862843 0.210297467407388 no 667 0.213591319283254 225 1206237
SGTC_1992 st073643 23.3 µM 0.792891836517066 0.210632574124781 no 668 0.213920421980122 241 3161292
SGTC_249 wiskostatin 11.211 µM 0.791013039213014 0.211190364784112 no 669 0.214468191272649 228 2775510 A n-wasp and actin depolymerizer.
SGTC_332 4112-0506 40.9 µM 0.790912371143584 0.211220276244821 no 670 0.214497564367948 269 2790355
SGTC_2330 7979373 200 µM 0.790740340039267 0.211271397518786 no 671 0.214547765300513 227 1863007
SGTC_1044 1222-0021 1.78 µM 0.790688992038604 0.211286657647763 no 672 0.214562750644041 244 4306703
SGTC_836 0330-0104 1.35 µM 0.790175859012115 0.21143919128417 no 673 0.214712536234631 238 46494820
SGTC_2925 9010536 32.5 µM 0.78908879235289 0.211762545048023 no 674 0.215030055994642 220 2994177
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.788799399377162 0.211848675275787 no 675 0.215114630309559 257 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1377 2944-0135 198 µM 0.787341847275076 0.212282788888297 no 676 0.215540889438285 222 1894137
SGTC_2211 7117706 200 µM 0.786680154502403 0.212480037248478 no 677 0.215734562145994 234 822771
SGTC_997 3996-0078 137 µM 0.7865745503998 0.21251152737612 no 678 0.215765481038089 234 735687
SGTC_3273 9137859 49.47 µM 0.785671772214068 0.212780838394103 no 679 0.216029902300729 273 2377234
SGTC_1022 4477-0945 21.3 µM 0.784961848639997 0.212992758128249 no 680 0.216237968757935 234 4648966
SGTC_1540 guanosine 70.6 µM 0.784303683313283 0.213189337440947 no 681 0.216430969363647 241 6802 Guanosine is a purine nucleoside
SGTC_3288 9119690 36.221 µM 0.782964020485535 0.213589791586572 no 682 0.216824120327958 255 17595618 YKL019W RAM2
SGTC_2414 st077232 92.9 µM 0.781089194290373 0.214150952855047 no 683 0.217375018419803 229 729801
SGTC_2334 9017922 200 µM 0.779199925888976 0.214717303742699 no 684 0.21793097688311 245 3163164
SGTC_635 k038-0028 24.7 µM 0.77812651086606 0.215039471504968 no 685 0.218247217604253 244 4035102
SGTC_2832 7992762 51.95 µM 0.777319249124794 0.21528194257045 no 686 0.218485220531114 246 2985177
SGTC_2348 9022543 33.42 µM 0.776719756465376 0.215462110234608 no 687 0.218662064097647 261 3162678 YDL140C RPO21
SGTC_2980 9014342 25.29 µM 0.776445969604501 0.215544421459511 no 688 0.218742855529432 252 2996599
SGTC_2656 pseudo-anisatin 100 µM 0.774265494071084 0.216200609820605 no 689 0.219386902332432 283 6708809 A neurotoxin.
SGTC_1426 4048-4480 71.7 µM 0.773522847617267 0.216424364299597 no 690 0.219606506230265 235 14224343
SGTC_2595 hexamethylquercetagetin 100 µM 0.773483708530965 0.216436160364631 no 691 0.219618083335063 258 386331
SGTC_1071 trifluoperazine 6.31 µM 0.772558444934966 0.21671513239232 no 692 0.219891872770041 259 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_631 k072-0230 41.5 µM 0.772191321536973 0.216825879700492 no 693 0.220000560402438 243 5773147
SGTC_156 3474-0145 5.642 µM 0.770941470142338 0.217203158048079 no 694 0.220370812466457 239 2265471
SGTC_2131 toluylene red 5.2905 µM 0.768765865588613 0.217860786643992 no 695 0.221016158017981 217 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2228 7354201 200 µM 0.767162022450936 0.218346321092946 no 696 0.221492594828386 269 753451
SGTC_1563 conessine 56.1 µM 0.766906307636513 0.218423791693769 no 697 0.221568611568285 238 441082 An anti-amoebic, histamine inhibitor.
SGTC_225 nsc-122657 1.016 µM 0.766892969898029 0.218427832889764 no 698 0.221572576907628 241 275685
SGTC_1455 4262-0120 131 µM 0.766256495186547 0.218620728157483 no 699 0.221761849400163 239 1529587
SGTC_2734 clemastine 41.6 µM 0.765134808316545 0.218960914405829 no 700 0.222095637211165 276 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1204 4049-0315 18.3 µM 0.764611619607543 0.219119691641751 no 701 0.222251423973583 248 588402
SGTC_549 1661-1316 519 µM 0.764482595919447 0.219158857905921 no 702 0.222289852165036 258 2857282
SGTC_3091 9116372 49.47 µM 0.762389846739901 0.219794691987811 no 703 0.222913682128099 242 17169793
SGTC_25 0118-0223 35.662 µM 0.762342202336747 0.219809179970145 no 704 0.222927896103374 251 5333628
SGTC_2728 chlorpromazine 9.18 µM 0.76070683102647 0.220306805249423 no 705 0.223416096897141 292 2726 A thorazine and dopamine antagonist.
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.760601426938421 0.220338900680425 no 706 0.223447583606637 245 5377381
SGTC_1837 st055472 66.5 µM 0.760257210748652 0.220443732806898 no 707 0.223550426756309 239 676091
SGTC_2563 tomatine 8.54 µM 0.75913838233131 0.220784672921683 no 708 0.223884890483418 253 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_213 1246-0773 967 nM 0.758190755437 0.221073678904827 no 709 0.224168397349046 247 6251622
SGTC_639 0833-0042 114 µM 0.7573023785629 0.221344811391975 no 710 0.224434363110356 273 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2432 5630864 12.22 µM 0.756199358826906 0.221681717326527 no 711 0.22476483857472 263 5714970
SGTC_2655 perillic acid 100 µM 0.754710665455812 0.222136887534068 no 712 0.225211302843295 259 5702197 An apoptosis inducer.
SGTC_2366 9070441 60.58 µM 0.754508876572695 0.222198625810164 no 713 0.225271858660044 235 6837235
SGTC_1787 fluconazole 80 µM 0.754266417393214 0.222272820307972 no 714 0.225344631620867 247 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1673 st016611 27.3 µM 0.753765231517503 0.222426232097321 no 715 0.225495102349659 274 5226799
SGTC_3189 9110682 49.47 µM 0.753327429999698 0.222560291490747 no 716 0.225626589756165 246 17122418
SGTC_2206 7254556 146.969 µM 0.752680021842911 0.222758619032169 no 717 0.225821108999248 221 4398905
SGTC_2623 humulene 100 µM 0.751678508153191 0.223065621875765 no 718 0.226122209003476 243 6187145 An anti-inflammatory.
SGTC_3147 9097027 49.47 µM 0.749880965235196 0.223617242445733 no 719 0.226663199800329 278 25236841
SGTC_1657 st012939 43.4 µM 0.749321266115183 0.223789158226468 no 720 0.22683179657215 250 24207257
SGTC_222 nsc-310342 10.666 µM 0.748488955664794 0.224044947496843 no 721 0.227082642152046 254 432556
SGTC_2611 pyromycin 23.93 µM 0.74820145537129 0.224133341916668 no 722 0.227169326650545 244 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2180 6301957 200 µM 0.748064561080687 0.224175438195087 no 723 0.227210608337809 245 845462
SGTC_1118 chelidonine 707.474 nM 0.747212153105461 0.224437662643791 no 724 0.227467754630018 254 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2965 9082772 38.63 µM 0.746790280536953 0.224567506771894 no 725 0.227595081728332 193 16459634
SGTC_819 1013-0258 27.7 µM 0.746119488709535 0.224774051109715 no 726 0.227797618783369 246 5753198
SGTC_2952 9073731 13.78 µM 0.745818653013464 0.224866716776173 no 727 0.227888485228564 266 16457353
SGTC_1265 0819-1001 68.8 µM 0.745465899473646 0.224975402147386 no 728 0.227995059261441 273 3106768
SGTC_2565 isoliquiritigenin 100 µM 0.742835221952903 0.22578686715322 no 729 0.228790724079291 245 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2163 5671233 125 µM 0.742257049400384 0.225965433273516 no 730 0.228965804678821 253 701023
SGTC_260 nsc-65238 3.989 µM 0.740188410865923 0.226604976888822 no 731 0.229592839312146 253 3246252
SGTC_1236 0330-0013 258 µM 0.737915713354608 0.22730878407767 no 732 0.230282834849399 262 4617066
SGTC_2022 5136654 200 µM 0.737266212818987 0.227510146961347 no 733 0.230480237371821 270 1713771
SGTC_1185 1319-0113 81.3 µM 0.735946993324077 0.227919450073745 no 734 0.230881478409722 256 4672763
SGTC_1910 st062352 60.4 µM 0.735129192228387 0.228173390192034 no 735 0.231130408590528 253 2245730
SGTC_3158 9100007 49.47 µM 0.734678765618009 0.228313322655191 no 736 0.231267577720603 258 19297233
SGTC_846 0335-0850 148 µM 0.734275399929949 0.228438675791919 no 737 0.231390453845858 254 6819598
SGTC_3070 9117005 49.47 µM 0.733086118042083 0.22880849150604 no 738 0.231752953188145 248 8779016
SGTC_1519 esterone 74 µM 0.732926923764266 0.228858019596627 no 739 0.231801500436463 263 698 A steroid.
SGTC_327 1273-0057 3.96 µM 0.732884668513393 0.228871166945803 no 740 0.231814387379626 254 3108138
SGTC_1021 4476-0760 85.3 µM 0.731577747133943 0.22927801327426 no 741 0.232213167313796 234 746768
SGTC_659 k018-0002 107 µM 0.730591108200021 0.229585423675188 no 742 0.232514472415551 265 6797879 YHR007C ERG11
SGTC_1308 1187-1617 41.4 µM 0.729906650512115 0.229798818038728 no 743 0.232723623435184 265 2882570
SGTC_2372 9071633 200 µM 0.729680796527027 0.229869257224468 no 744 0.232792660997174 252 21321366
SGTC_2148 5546263 113.568 µM 0.728068701549037 0.230372387204422 no 745 0.233285765959557 249 792097
SGTC_1367 1812-0510 76.9 µM 0.727355500800132 0.230595171307781 no 746 0.233504103440131 238 1142582 YDR527W RBA50
SGTC_2100 5377183 190 µM 0.726709227061216 0.230797153203589 no 747 0.233702049899711 244 2844202
SGTC_2086 5274770 176.623 µM 0.725875334757709 0.231057918040392 no 748 0.233957599232923 266 689278
SGTC_808 0711-0032 135 µM 0.725518502857547 0.231169552466522 no 749 0.234066998945016 261 4252555
SGTC_1899 st063254 59.6 µM 0.725253315433609 0.231252535519494 no 750 0.23414832007978 256 3093813
SGTC_101 0490-5701 117.494 µM 0.724173343126105 0.231590654499577 no 751 0.234479660868033 246 4661669
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.723901649496487 0.231675760015687 no 752 0.234563058622744 270 61125 An anti-inflammatory.
SGTC_3169 9102970 49.47 µM 0.722004607472103 0.232270476303432 no 753 0.235145822391585 269 17027839
SGTC_1699 st031318 29.054 µM 0.721469441909026 0.232438402392314 no 754 0.235310367616742 258 5340658
SGTC_118 0083-0097 135.343 µM 0.719597258188068 0.233026393591838 no 755 0.235886500328241 299 5207356
SGTC_2272 7805186 180 µM 0.719092843802653 0.233184954661522 no 756 0.236041858142261 286 2956062 YPR165W RHO1
SGTC_420 mitomycin C 81.9 mM 0.719028643647202 0.233205140073255 no 757 0.236061635602592 253 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2865 9030313 51.95 µM 0.71843027089588 0.233393323334749 no 758 0.236246013848699 259 42562754
SGTC_196 k015-0023 18.111 µM 0.716487329179244 0.2340049428934 no 759 0.236845244316237 239 5211998
SGTC_688 0527-0193 473 µM 0.716400052351184 0.234032437628531 no 760 0.236872181312954 294 4007154
SGTC_1960 st011366 51.8 µM 0.715258751569187 0.234392145157973 no 761 0.23722458575592 283 3972846
SGTC_586 0957-0265 8.15 µM 0.713395802259625 0.234979953745346 no 762 0.237800434959971 265 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2265 7929201 200 µM 0.712139076404473 0.235376942777234 no 763 0.238189329349051 281 1265108
SGTC_3134 9127454 49.47 µM 0.710654145457619 0.235846496605685 no 764 0.238649290670487 272 24262820
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.710391514261569 0.235929597599775 no 765 0.238730691940186 269 1377
SGTC_732 3970-1727 52.7 µM 0.709913057631895 0.236081030918068 no 766 0.238879026297416 275 1275699
SGTC_3103 9120822 49.47 µM 0.708691093833814 0.236468029965802 no 767 0.239258096429377 278 17141819
SGTC_1951 sophoraflavanone G 9.2 µM 0.708267516817284 0.23660225933372 no 768 0.239389572564712 255 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_724 3910-0327 137 µM 0.708139801763174 0.236642739798476 no 769 0.239429222404109 279 2885483
SGTC_1352 1496-0991 99 µM 0.706232939697697 0.237247590226809 no 770 0.240021644500769 274 3000039
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.706173141432221 0.237266571763615 no 771 0.240040235485189 257 6708514
SGTC_1247 0448-0043 5.84 µM 0.705744818780068 0.237402556981194 no 772 0.240173421824338 267 3089013 YGL099W LSG1
SGTC_2297 7971671 152.32 µM 0.703530667972168 0.238106194383275 no 773 0.240862550779152 263 909016
SGTC_1479 0549-0158 134 µM 0.703144887864688 0.238228908672911 no 774 0.240982730342566 256 5440202
SGTC_2232 chlorophetanol 41.5365 µM 0.701773484303874 0.238665424126155 no 775 0.241410218661713 270 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_3120 9124077 49.47 µM 0.701754656770737 0.238671419942484 no 776 0.241416090368691 282 18774327 YGL155W CDC43
SGTC_1060 3448-7350 82 µM 0.701627660388487 0.238711865364221 no 777 0.241455698515527 269 570178
SGTC_958 1222-0007 33 µM 0.701280041476794 0.238822593157015 no 778 0.241564133363177 278 7312461
SGTC_173 1273-0061 2.693 µM 0.699851510132183 0.239277921101526 no 779 0.242010021178014 266 2847414 YPL266W DIM1
SGTC_280 3448-3607 3.04 µM 0.699688032219106 0.239330058032783 no 780 0.242061076025354 245 626179
SGTC_1664 st014217 9.02 µM 0.698116262326176 0.239831648738227 no 781 0.242552244351494 269 3982782
SGTC_56 0957-0365 83.25 µM 0.697311823070023 0.240088586923932 no 782 0.242803835279951 253 6752360
SGTC_57 miconazole 162.5 nM 0.695795591422509 0.240573279555739 no 783 0.243278425264222 261 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3077 9117319 49.47 µM 0.695317416525076 0.240726247791077 no 784 0.243428200927513 299 17154678
SGTC_1212 0520-0165 585 µM 0.694619121478943 0.240949727562007 no 785 0.24364701288612 303 5403258
SGTC_1450 4112-4260 37.6 µM 0.694066340164385 0.241126717644565 no 786 0.243820303150397 279 1633175
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.693907574365039 0.241177564501289 no 787 0.243870086604112 296 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2516 gossypol 71.55 µM 0.693311980312466 0.241368363342027 no 788 0.244056893139774 281 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_382 3229-0966 23.2 µM 0.68970376631372 0.24252600776834 no 789 0.245190248441942 277 5722370
SGTC_347 4534-1311 26.2 µM 0.688692620936646 0.242850958059311 no 790 0.245508360394658 276 2862016
SGTC_2677 mitomycin C 100 µM 0.686959441591504 0.243408494925662 no 791 0.246054143606406 290 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1788 fluconazole 20 µM 0.686566056847971 0.243535136919132 no 792 0.246178112174539 284 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_879 0831-1030 162 µM 0.686559861717218 0.243537131596563 no 793 0.246180064733382 276 1549252
SGTC_318 1488-0629 67.2 µM 0.686013907486678 0.243712949878154 no 794 0.246352169218091 284 3662576
SGTC_1909 st060837 51.5 µM 0.685614434991538 0.243841638802403 no 795 0.246478138217364 274 678937
SGTC_983 1491-0821 12.2 µM 0.684895442096524 0.244073352685146 no 796 0.246704951189341 259 46495113
SGTC_1015 4130-4525 82 µM 0.68480724185607 0.244101785648019 no 797 0.246732782466768 279 1363237
SGTC_1486 3970-0793 4.53 µM 0.684077080626683 0.244337235082711 no 798 0.246963246840776 285 2844330
SGTC_1109 tnp00067 928.257 nM 0.683842733660521 0.244412829071645 no 799 0.247037239335604 267 676295
SGTC_2244 6635614 200 µM 0.683113862401526 0.244648023744742 no 800 0.247267448263792 278 836499
SGTC_1870 st057514 26.5 µM 0.682430230120046 0.244868731266958 no 801 0.247483472973018 281 5393161
SGTC_1725 st036284 20.55 µM 0.681829260378534 0.245062840040634 no 802 0.247673459954337 264 707914
SGTC_799 1310-0557 151 µM 0.681398979843392 0.245201868292925 no 803 0.247809534104857 289 5354492
SGTC_1350 1495-0454 146 µM 0.680842334408018 0.245381789301172 no 804 0.247985629745654 263 1069057
SGTC_1826 st055655 41.6 µM 0.679681432143262 0.245757248623047 no 805 0.248353097700779 278 676168
SGTC_184 1494-0393 24.714 µM 0.679675504831389 0.245759166426941 no 806 0.248354974655918 285 3090647
SGTC_634 1611-4317 11.2 µM 0.679647261544511 0.245768304758249 no 807 0.248363918338852 292 2843522
SGTC_1591 genipin 88.4 µM 0.679333965594281 0.245869686291658 no 808 0.248463139964333 299 442424 A DNA cross-linking agent.
SGTC_1490 4089-0339 670 nM 0.677040843135337 0.2466124160401 no 809 0.249190020368279 278 742542
SGTC_2804 7954240 19.48 µM 0.676772646425172 0.246699361907882 no 810 0.249275107924459 275 828705
SGTC_1165 k072-0275 30.3 µM 0.675638064366178 0.247067360115314 no 811 0.249635234017471 280 6153523 YGL055W OLE1
SGTC_1871 st057448 67.3 µM 0.675601264119855 0.247079301077145 no 812 0.249646919357184 297 691747
SGTC_1583 clindamycin 39.6 µM 0.675525960622285 0.247103736554859 no 813 0.249670831704549 285 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2253 7938677 135.83 µM 0.674157367601711 0.247548060915692 no 814 0.250105635240383 266 2301972
SGTC_2618 avocadyne 43.43 µM 0.672112433004083 0.248212759387802 no 815 0.250756060998446 279 3015189
SGTC_792 4534-1957 155 µM 0.671665798550612 0.248358062812005 no 816 0.250898239660875 277 1717904
SGTC_1623 st003709 20.3 µM 0.669951276795329 0.248916268401202 no 817 0.251444425243624 270 16192618
SGTC_1248 0469-0687 58.6 µM 0.669243072807498 0.249147036709438 no 818 0.251670217066629 272 4017482
SGTC_2299 7976368 114.88 µM 0.668934262923568 0.249247698043734 no 819 0.251768706322724 279 2979718
SGTC_50 0929-0078 56.389 µM 0.667288439837925 0.249784543966079 no 820 0.252293954520983 255 1377751
SGTC_2369 9071472 200 µM 0.66685846496451 0.249924897214209 no 821 0.252431271880557 287 17296037
SGTC_1554 st069299 38.7 µM 0.665499310413878 0.250368830255565 no 822 0.252865592232643 257 24207999
SGTC_2030 5175110 200 µM 0.664608051286858 0.250660163993478 no 823 0.253150609128296 302 2831986
SGTC_2457 5731572 11.68 µM 0.664416001711507 0.250722964438845 no 824 0.253212047027333 289 2865357
SGTC_587 k089-0003 57 µM 0.663485669090195 0.251027302247291 no 825 0.253509777394944 287 9659696
SGTC_2441 5730946 39.09 µM 0.663384069262022 0.251060550226002 no 826 0.253542303090117 270 1774275
SGTC_1860 st056228 74.6 µM 0.663206363269031 0.251118709124615 no 827 0.253599198328519 307 688679
SGTC_407 eburnamonine 100 µM 0.660664741776069 0.251951300002395 no 828 0.254413669894063 272 3195
SGTC_2522 biochanin a 4.94 µM 0.65891685975346 0.252524719958156 no 829 0.254974579356057 269 5280373 A possible chelator.
SGTC_3238 9133470 49.47 µM 0.657878708235211 0.252865626961038 no 830 0.255308036597237 264 3534688
SGTC_2087 5276107 200 µM 0.657795690387038 0.252892898723474 no 831 0.255334712008087 285 144405
SGTC_999 SEC7.066 22.7 µM 0.657744451927251 0.252909731576546 no 832 0.255351176748526 286 740511 YDR170C SEC7
SGTC_3278 9139605 49.47 µM 0.657424589545001 0.253014826059926 no 833 0.255453972457561 292 7958859
SGTC_878 0828-0289 13.7 µM 0.657007232165837 0.253151988194728 no 834 0.25558813310791 293 745350 YLR208W SEC13
SGTC_2913 7966556 36.57 µM 0.656620112571453 0.253279247805343 no 835 0.255712606632307 270 2976516
SGTC_337 1315-0038 354 µM 0.655796915467024 0.25354997295555 no 836 0.255977400670873 280 1626437
SGTC_77 0828-0286 12.516 µM 0.655603363621318 0.253613648493145 no 837 0.256039680371648 276 745345
SGTC_1326 1431-2094 10.8 µM 0.655042641672142 0.253798164670485 no 838 0.256220149998046 304 616278
SGTC_1404 3909-7820 48.3 µM 0.654752359255747 0.253893715277073 no 839 0.256313604097 279 23741373
SGTC_616 4092-0450 108 µM 0.654137406443132 0.254096198133771 no 840 0.256511641901215 312 787165
SGTC_1755 st041960 45.185 µM 0.653138085068799 0.254425420944461 no 841 0.256833630685836 299 2257073
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.652556986236295 0.254616964588947 no 842 0.257020961732791 293 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1155 4088-0394 48.2 µM 0.652469320491396 0.254645867805809 no 843 0.257049229042075 289 2326248
SGTC_65 0798-0905 34.986 µM 0.652241284689099 0.254721058791048 no 844 0.257122765432343 328 3602145
SGTC_112 phenothiazine 287.218 µM 0.651913328242525 0.254829217313546 no 845 0.257228543148208 305 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.650953345061289 0.255145953457859 no 846 0.257538302128887 283 4330530
SGTC_3113 9123498 49.47 µM 0.646120018588217 0.256743780049538 no 847 0.259100815922306 309 8897275
SGTC_1685 st024049 53.0905 µM 0.64544963848228 0.256965808483047 no 848 0.259317922268324 295 1941139
SGTC_1126 isoteolin 1.0172 µM 0.644982392837976 0.257120618278639 no 849 0.259469297954128 288 133323
SGTC_2800 7887935 81.82 µM 0.644921616533002 0.257140758504059 no 850 0.259488991282454 298 2961002
SGTC_237 nikkomycin 200 µM 0.644740641336926 0.257200735438953 no 851 0.259547637193642 295 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1655 st012546 55.1 µM 0.640872024391924 0.258484569937215 no 852 0.260802916590395 296 720985 YLR208W SEC13
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.640316181693777 0.25866930356101 no 853 0.260983531355593 275 688664
SGTC_2889 9059656 51.95 µM 0.640124230967262 0.258733114017484 no 854 0.261045918498809 298 3949838
SGTC_2816 7982706 58.44 µM 0.639661613279087 0.258886936155928 no 855 0.261196308356119 294 2981853
SGTC_928 2764-0428 58.7 µM 0.6394167037579 0.258968388651552 no 856 0.261275942674767 293 662578
SGTC_3228 9131799 49.47 µM 0.638970848162741 0.259116706215775 no 857 0.261420948257344 296 17015818
SGTC_2692 st077426 47.7 µM 0.637845392823111 0.259491293531112 no 858 0.261787163754604 285 25238571
SGTC_2770 toltrazuril 17.5 µM 0.636402412353831 0.259971972128057 no 859 0.26225708447737 267 68591 Kills coccidiodes.
SGTC_1011 4112-3381 17.4 µM 0.635351221647223 0.260322428521237 no 860 0.262599686874628 305 2877139
SGTC_1355 1499-0035 1.68 µM 0.634263653374362 0.260685268835033 no 861 0.262954386298194 298 1548538
SGTC_3221 9128209 49.47 µM 0.633023158387791 0.261099446885824 no 862 0.263359260014615 305 16460723
SGTC_2798 7813637 45.45 µM 0.631316620321788 0.261669780225494 no 863 0.263916760895846 288 956368
SGTC_2730 imipramine 71.33 µM 0.630266865759356 0.262020930625695 no 864 0.264259998864705 279 3696 A tricyclic antidepressant.
SGTC_3286 9117135 37.221 µM 0.630122034638012 0.262069396626423 no 865 0.264307372095926 283 3438150
SGTC_403 arphamenine a 50 µM 0.629706658790666 0.26220842266259 no 866 0.264443262565027 295 5487158 An arginine aminopeptidase inhibitor.
SGTC_2258 7960471 200 µM 0.629290427603026 0.262347772873863 no 867 0.26457946851794 311 2974708
SGTC_1822 st052468 42 µM 0.628650990992901 0.262561923984114 no 868 0.264788784894727 294 2873678
SGTC_901 1112-0062 60.1 µM 0.627675553317427 0.262888776092458 no 869 0.265108251632971 293 1908457
SGTC_1799 st045822 46.1415 µM 0.625682274323435 0.263557335356328 no 870 0.265761680993472 300 3674992
SGTC_2814 7977482 42.97 µM 0.625456974926125 0.263632956837231 no 871 0.265835589132698 288 6456762
SGTC_1928 4'-methoxychalcone 40.3 µM 0.625106307856335 0.263750679850701 no 872 0.265950644118599 304 641818
SGTC_1246 0422-0085 105 µM 0.62474158146566 0.263873151178723 no 873 0.266070338772969 313 264295
SGTC_2315 7733312 200 µM 0.622924041038523 0.264483894269335 no 874 0.266667219404937 289 726316
SGTC_2383 9036125 200 µM 0.622510673424408 0.264622897384454 no 875 0.266803063832067 291 79580
SGTC_942 3253-1115 227 µM 0.621946569278852 0.264812648607401 no 876 0.266988501002303 329 46497897
SGTC_1387 3342-1166 1.8 µM 0.619144686150629 0.265756159398054 no 877 0.267910523702181 295 3418228
SGTC_448 monastrol 171 µM 0.61680214637947 0.266546296026929 no 878 0.268682618043172 303 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_663 1486-0733 13.9 µM 0.616687276068055 0.266585072218589 no 879 0.268720507701678 300 722445 YPR165W RHO1
SGTC_2714 st079313 56.9 µM 0.61611739901002 0.266777484911426 no 880 0.268908519776294 295 2939799
SGTC_1412 3909-8563 178 µM 0.613466916530642 0.26767331237599 no 881 0.269783825790896 316 23767530
SGTC_190 3970-0790 3.722 µM 0.611653480359395 0.268287101737398 no 882 0.270383523160805 299 2832352
SGTC_2098 5376439 882.5 nM 0.611137664585431 0.268461817904279 no 883 0.270554223371033 299 2844116
SGTC_2659 sanguinarine 24.21 µM 0.610873106263334 0.268551450800445 no 884 0.270641795203659 308 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1232 0279-0259 161 µM 0.610613790293314 0.268639322172859 no 885 0.270727645493619 307 1560000
SGTC_3247 9135149 49.47 µM 0.609620279644671 0.268976115178109 no 886 0.271056687303055 303 8934436 YOR116C RPO31
SGTC_1821 st053465 65.6 µM 0.607675295934852 0.269636063810784 no 887 0.271701425400186 286 675086
SGTC_1977 st070720 65.3 µM 0.606993074475904 0.269867739061643 no 888 0.271927754101521 274 682188
SGTC_1689 st020265 53.493 µM 0.605095073745361 0.270512804028615 no 889 0.272557913641894 308 5758320 YPR016C TIF6
SGTC_1076 itraconazole 331 nM 0.604098494878508 0.270851814973034 no 890 0.27288908008065 303 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2791 5663188 71.43 µM 0.604003105458879 0.270884275158822 no 891 0.272920788760284 317 54690634
SGTC_1640 st009078 66.4 µM 0.603685268969198 0.270992446147518 no 892 0.273026454913924 304 690618
SGTC_2802 7925815 54.55 µM 0.603348162869242 0.271107198809295 no 893 0.273138549492673 308 1262923
SGTC_2799 7812892 81.82 µM 0.602470455905007 0.271406088443966 no 894 0.273430511713421 310 20205235
SGTC_783 0848-0141 92.7 µM 0.602296350157473 0.271465396991776 no 895 0.273488444960942 324 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_188 3229-0966 278.469 µM 0.599035996129149 0.272577216833704 no 896 0.274574440425296 308 5722370
SGTC_1809 st050081 57.6 µM 0.598857305808807 0.272638217655638 no 897 0.274634022047498 309 5036894
SGTC_3074 9116018 49.47 µM 0.598397184781456 0.272795323716585 no 898 0.274787471886142 340 17027303
SGTC_1618 st003135 44.5 µM 0.598186257320088 0.272867358870491 no 899 0.274857830080966 320 1270615
SGTC_1424 4048-1941 275 µM 0.595916524243779 0.273643106032953 no 900 0.27561549684453 311 X1424
SGTC_439 amiodarone 34.4 µM 0.595668458500643 0.273727955799998 no 901 0.275698366662897 311 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_3303 9125618 40.5795 µM 0.595314047512898 0.273849203051227 no 902 0.275816783837685 305 22695467
SGTC_561 1550-0330 72.9 µM 0.595021171678076 0.273949418597067 no 903 0.275914659504772 312 6812934
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.594518735795622 0.274121383107058 no 904 0.276082607410397 304 5379071
SGTC_847 0342-0274 5.54 µM 0.594014763503104 0.27429392702682 no 905 0.276251119292877 323 18097
SGTC_1133 3473-0247 50 µM 0.593970998717986 0.274308913213231 no 906 0.276265755189686 295 711311
SGTC_49 0717-0965 32.132 µM 0.593481192702098 0.274476662947076 no 907 0.27642958293604 330 5889349 YGL099W LSG1
SGTC_297 0986-0032 24 µM 0.593304669168935 0.274537131483266 no 908 0.276488637278615 309 2847425
SGTC_2152 5568786 200 µM 0.592810524286965 0.274706436874835 no 909 0.276653981842291 316 5399883
SGTC_2465 5809242 33.21 µM 0.591914407108082 0.275013598494894 no 910 0.276953952896526 340 2731748
SGTC_1605 st000082 49.1 µM 0.590638262556813 0.275451313731197 no 911 0.27738141101401 308 1114022
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.590607269526351 0.275461948545096 no 912 0.277391796468248 327 65057 A dermal irritant. YDR527W RBA50
SGTC_2606 farnesol 9.78 µM 0.5905753425563 0.275472904038173 no 913 0.277402495075078 317 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2394 5221648 200 µM 0.590492422903832 0.275501358277366 no 914 0.277430282079086 311 788586
SGTC_315 k915-0449 187 µM 0.589266750878649 0.275922121496097 no 915 0.277841172690588 313 20970215 YNL149C PGA2
SGTC_952 1185-0122 232 µM 0.588666485052136 0.276128302952175 no 916 0.278042512327862 297 678600
SGTC_3052 9092717 49.47 µM 0.58725921565522 0.276611973178805 no 917 0.278514813927552 318 25237534
SGTC_2112 5488546 200 µM 0.587082320292667 0.276672800441965 no 918 0.27857421041533 329 600757
SGTC_2772 vinpocetine 57.06 µM 0.586697671520378 0.276805088438625 no 919 0.278703385944053 344 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2600 tangeritin 87.95 µM 0.586483107309371 0.276878894593081 no 920 0.278775455115232 318 68077 A bioactive flavone.
SGTC_559 1550-0661 158 µM 0.585951655039714 0.277061745916188 no 921 0.278954001681158 312 5830875
SGTC_2511 berberine 10.47 µM 0.584446355283247 0.277579979485992 no 922 0.279460023504745 314 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2464 5717415 7.67 µM 0.584257548765806 0.277645013823791 no 923 0.279523524186197 292 5285744
SGTC_1092 toremifene 6.32 µM 0.583056735321368 0.278058807712308 no 924 0.279927553758456 333 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_466 geldanamycin 89.2 µM 0.581234361510318 0.278687362174757 no 925 0.280541256009606 292 5288382 HSP90 inhibitor.
SGTC_2260 7964312 200 µM 0.58017137660878 0.27905431517198 no 926 0.280899527015288 307 231951
SGTC_2187 6125751 200 µM 0.580001701534404 0.279112910439863 no 927 0.280956735175573 310 874498
SGTC_335 4077-0256 27.6 µM 0.579422605852916 0.279312939279573 no 928 0.281152027216476 319 3121989
SGTC_824 1304-0008 100 µM 0.579338285965961 0.279342070515118 no 929 0.28118046840402 311 768245
SGTC_1661 st013063 9.66 µM 0.577563362649565 0.279955621788823 no 930 0.281779474155772 326 721395
SGTC_2026 5148700 152 µM 0.575947065485807 0.280514907378328 no 931 0.282325480839165 295 79838
SGTC_2720 fluspirilene 36.88 µM 0.574303018517621 0.281084349402692 no 932 0.282881383455883 310 3396 An atypical antipsychotic.
SGTC_2226 7298446 200 µM 0.572873566627012 0.281579916395002 no 933 0.283365151721241 324 3283010
SGTC_994 3910-0338 138 µM 0.572439074342249 0.281730631047477 no 934 0.28351227516955 305 3479481
SGTC_3293 9120939 62.045 µM 0.571214369849278 0.282155659983316 no 935 0.283927169303319 325 934087
SGTC_1164 k060-0068 93.7 µM 0.571212090054959 0.282156451464825 no 936 0.283927941901964 307 5963676
SGTC_585 0kpi-0023 191 µM 0.566646047495494 0.283743795895213 no 937 0.285477341664022 311 64601
SGTC_2316 5844804 197.44 µM 0.564384637978914 0.284531535224979 no 938 0.286246195666836 324 776813
SGTC_658 3253-0951 102 µM 0.563524389850542 0.284831468034474 no 939 0.286538928384968 317 1184878
SGTC_1263 0774-1208 64.8 µM 0.563489470926467 0.284843645998944 no 940 0.286550813899065 341 906585
SGTC_1291 0993-0025 5.79 µM 0.560110726773458 0.28602315530583 no 941 0.287701957120086 312 4353356
SGTC_1596 piperlongumine 63 µM 0.556274097190803 0.287365318648545 no 942 0.289011745953703 293 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_177 1327-0068 8.361 µM 0.555970507406618 0.287471650167212 no 943 0.289115508268885 305 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_3078 9116413 49.47 µM 0.554937261225285 0.287833681262885 no 944 0.289468787117614 308 17177322
SGTC_3110 9122132 49.47 µM 0.554452874885863 0.288003475734189 no 945 0.28963447419958 292 918317
SGTC_1760 st045453 10.4495 µM 0.552234912467563 0.288781552956121 no 946 0.290393708796172 330 3323419 YIL048W NEO1
SGTC_1463 k081-0032 34.1 µM 0.552063444125612 0.288841746476286 no 947 0.290452443206572 312 977755
SGTC_1733 st037357 54.9 µM 0.549669356845794 0.289682800875826 no 948 0.291273089135227 324 1272339 YGL099W LSG1
SGTC_2119 5528445 120.635 µM 0.549663703592063 0.289684788250678 no 949 0.291275028239363 320 791935
SGTC_2224 6650123 117.647 µM 0.549114313312658 0.28987795434952 no 950 0.291463501547808 325 2908370
SGTC_411 enrofloxacin 100 µM 0.548356416960289 0.290144530476902 no 951 0.291723598079432 326 71188 A bacterial gyrase inhibitor.
SGTC_2927 9011802 47.9 µM 0.546736841618046 0.290714571064925 no 952 0.292279769743039 315 43912568
SGTC_32 0928-0142 34.1 µM 0.546395717138949 0.290834703109092 no 953 0.292396976738844 333 2244242
SGTC_1245 0418-0076 17.2 µM 0.545736675323796 0.291066860160862 no 954 0.292623478856348 350 6790114
SGTC_2125 5246583 200 µM 0.545418644853398 0.291178921969539 no 955 0.29273280998659 342 835267
SGTC_3198 9112019 49.47 µM 0.542741118032411 0.29212317806713 no 956 0.293654029745908 367 45595555
SGTC_3203 9113543 49.47 µM 0.541797189546731 0.292456403126264 no 957 0.293979113849649 326 17018012
SGTC_757 1066-0008 322 µM 0.537716467238455 0.293899006252123 no 958 0.295386404409884 318 6842497
SGTC_1102 cgs 12066b 26.1 µM 0.537338618018367 0.294032748538542 no 959 0.295516867292304 320 6438352 A 5-HT1B full agonist.
SGTC_3013 9080133 71.4286 µM 0.536441488211797 0.294350406348719 no 960 0.295826732237485 323 17050193
SGTC_221 trifluoperazine 10.304 µM 0.535407997570004 0.294716543422079 no 961 0.296183880534834 330 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_113 0099-0221 2.5 µM 0.534788479031311 0.294936122295364 no 962 0.296398065297386 322 89219
SGTC_2875 9039966 71.43 µM 0.533904965290257 0.295249400580587 no 963 0.296703643301438 348 6463691
SGTC_1898 st060199 18.6 µM 0.533774270581019 0.295295755605352 no 964 0.296748858497982 309 688866
SGTC_2347 9049783 174.81 µM 0.533272243010443 0.295473846744496 no 965 0.296922569492309 350 6467988 YPL169C MEX67
SGTC_54 0159-0055 9 µM 0.533129075795529 0.295524643468963 no 966 0.296972116569738 350 3319099
SGTC_2507 purpurin 79.67 µM 0.53094998929222 0.296298293732382 no 967 0.297726717715303 322 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_95 0471-0001 561.058 µM 0.530435618219877 0.296481048463594 no 968 0.297904968055622 303 4015405
SGTC_2959 9079155 11 µM 0.529660480351836 0.296756550506232 no 969 0.298173676485861 351 16189457
SGTC_2005 4024620 188 µM 0.528098287982582 0.297312145865624 no 970 0.298715559518171 341 236743
SGTC_758 0868-0029 16 µM 0.526154821544922 0.298004004380985 no 971 0.299390320570668 309 762687
SGTC_2486 5283202 22.39 µM 0.525993941478784 0.298061309269139 no 972 0.299446208224559 326 1377751
SGTC_472 calcifediol 10 µM 0.525367537761434 0.298284479792244 no 973 0.299663857821056 323 5283731 A vitamin D metabolite.
SGTC_3053 9095903 49.47 µM 0.525363208733345 0.298286022371304 no 974 0.299665362230065 368 17174018
SGTC_2704 st078022 71.1 µM 0.525205115168954 0.298342358941147 no 975 0.299720304707773 336 54697681
SGTC_145 3737-0113 38.366 µM 0.52484478681457 0.298470779883071 no 976 0.299845547172281 353 6849351
SGTC_3188 9110789 49.47 µM 0.524305234291013 0.298663123290367 no 977 0.300033128429452 336 849217
SGTC_3170 9103054 49.47 µM 0.523715669315677 0.298873359893864 no 978 0.300238157733292 336 16432970
SGTC_51 1013-0126 23.419 µM 0.523624249871929 0.298905965736422 no 979 0.30026995576976 347 1627850
SGTC_1492 4158-0558 28.5 µM 0.52074500843833 0.299933707535825 no 980 0.301272207992657 302 3967268
SGTC_326 k292-0812 17.5 µM 0.520071079199858 0.300174496560175 no 981 0.301507017435793 345 3579357
SGTC_3063 1327-0034 4 µM 0.518550002404046 0.300718285012322 no 982 0.302037291226194 336 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2683 piperine 63.03 µM 0.51492986284091 0.302014277756256 no 983 0.303301016045792 344 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_696 1560-0013 611 µM 0.514494299809462 0.302170376172247 no 984 0.303453222327454 310 1650269
SGTC_402 epigallocatechin gallate 10 µM 0.514287521282756 0.302244494770322 no 985 0.303525492447203 336 65064 An antioxidant.
SGTC_1269 0831-0796 3.05 µM 0.513881830857035 0.302389935917475 no 986 0.303667305591409 335 927758
SGTC_709 3807-1509 243 µM 0.513788538916511 0.302423385776428 no 987 0.303699920904006 358 1886677 YPL242C IQG1
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.513465323454785 0.302539287627646 no 988 0.303812930678665 303 6857784
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.512332865139882 0.302945532919532 no 989 0.304209033859744 338 15053
SGTC_3038 9091290 49.47 µM 0.511230522265787 0.303341209267358 no 990 0.304594824275545 360 25236843
SGTC_2133 5320837 200 µM 0.510970757272149 0.303434483258316 no 991 0.304685766725136 344 2841355
SGTC_3241 9133421 49.47 µM 0.510464125723239 0.303616436643781 no 992 0.304863170671957 354 17018221
SGTC_1090 efavirenz 20.7 µM 0.509838975871566 0.303841022208665 no 993 0.305082138657859 338 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1452 4194-0072 190 µM 0.509622216144385 0.303918910605688 no 994 0.305158078260114 337 1343545
SGTC_1237 0330-0133 46.1 µM 0.507546161710558 0.304665350987748 no 995 0.305885827733877 360 X1237 YHR072W ERG7
SGTC_3185 9108267 49.47 µM 0.507299931984512 0.304753936350629 no 996 0.305972193151489 339 4910486
SGTC_2185 6113692 200 µM 0.507100258402283 0.304825780749528 no 997 0.306042236859102 341 874150
SGTC_1783 st039459 87.517 µM 0.506700018525914 0.304969813414278 no 998 0.306182658784744 394 729761
SGTC_1476 4112-3294 3.34 µM 0.505956102828476 0.305237603548237 no 999 0.306443733104197 330 704369
SGTC_2818 7996756 12.99 µM 0.504700142797095 0.305689952822251 no 1000 0.306884730374823 348 2241621
SGTC_761 k216-0224 480 µM 0.504361791604399 0.305811864874555 no 1001 0.307003581314777 377 1340404
SGTC_1607 st000305 50.6 µM 0.503781724658643 0.306020920126921 no 1002 0.307207385734732 352 5457690
SGTC_1679 SEC14.276 6.7 µM 0.502559211139276 0.306461719057235 no 1003 0.307637106425156 373 1005053 YMR079W SEC14
SGTC_3184 9108758 49.47 µM 0.50112413600734 0.306979518342549 no 1004 0.308141880702352 341 902885
SGTC_662 k832-1615 104 µM 0.501078221184033 0.306996091549693 no 1005 0.308158036811991 353 5878478
SGTC_832 4083-0019 164 µM 0.499970064502361 0.307396206336669 no 1006 0.308548078055618 331 1990758
SGTC_1384 3089-0840 101 µM 0.497654831022832 0.308232892002218 no 1007 0.309363674913788 313 1069836
SGTC_447 ml7 120 µM 0.494789933532621 0.309269597311601 no 1008 0.310374205425606 362 4216 Selective myosin light chain kinase inhibitor.
SGTC_2727 riluzole 51.77 µM 0.494716701947254 0.309296117199286 no 1009 0.310400055096407 353 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2569 tetrandrine 100 µM 0.493972667634641 0.30956561607167 no 1010 0.310662741323895 307 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.49375706672873 0.309643728661952 no 1011 0.310738878697239 349 4620898
SGTC_1348 1493-0373 93.8 µM 0.491413312013116 0.310493429330907 no 1012 0.311567075417289 371 3010129
SGTC_224 benfluorex 43.875 µM 0.491208157868926 0.310567853790954 no 1013 0.31163961482478 365 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_747 3448-8087 38.7 µM 0.49042764927442 0.310851072372298 no 1014 0.311915657670484 356 5168703
SGTC_1776 st049249 45.9 µM 0.488310770562795 0.311619775676078 no 1015 0.312664866825268 325 1822314
SGTC_636 0kpi-0074 126 µM 0.487979147729436 0.311740272582851 no 1016 0.31278230558357 336 616434
SGTC_1439 4092-1168 46 µM 0.487652734377783 0.311858896283156 no 1017 0.312897918050436 353 2886240
SGTC_612 0302-0167 22.4 µM 0.485183725606762 0.312756804088447 no 1018 0.313773012626508 367 235821
SGTC_1513 0337-0559 19 µM 0.485116576294968 0.312781239929677 no 1019 0.313796827130496 332 775073
SGTC_1000 4048-0884 8.67 µM 0.485023805507966 0.312815000858119 no 1020 0.313829729567117 356 13040088
SGTC_2517 totarol 10 µM 0.483843792693292 0.313244565294433 no 1021 0.314248366462815 318 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1880 MG-132 525 µM 0.483693939933699 0.313299134904061 no 1022 0.314301547320698 357 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1256 0570-0116 285 µM 0.479673820402816 0.314764603699747 no 1023 0.315729673049866 348 410638
SGTC_302 1094-0063 18.9 µM 0.479544542850655 0.314811778329592 no 1024 0.31577564404435 350 5440289
SGTC_3031 9088762 49.47 µM 0.477732393624401 0.315473366920005 no 1025 0.316420342571222 339 205253
SGTC_914 3820-6779 408 µM 0.477638333280692 0.315507723123616 no 1026 0.316453821168383 315 2893481
SGTC_110 0850-0284 111.64 µM 0.477317257484284 0.31562501033392 no 1027 0.316568111978035 333 3906265
SGTC_3008 9078912 71.4286 µM 0.476089513851029 0.316073669499539 no 1028 0.317005303637305 357 16648731
SGTC_1121 fusaric acid 630.51 nM 0.475834803608682 0.316166783226227 no 1029 0.317096036359954 320 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1174 0739-0097 51.1 µM 0.475621282558995 0.316244848517007 no 1030 0.3171721051681 362 728447
SGTC_1548 st061468 90.8 µM 0.474980937458031 0.316479013775063 no 1031 0.317400280226025 359 390799
SGTC_3130 9127414 49.47 µM 0.474253294210269 0.316745192066728 no 1032 0.317659646599149 332 1494646
SGTC_1288 0973-0013 65.5 µM 0.47343297723836 0.317045385027095 no 1033 0.317952153600635 339 4315430
SGTC_1690 st023502 41.2 µM 0.472244904763055 0.317480370729621 no 1034 0.318375995536637 371 24207482
SGTC_1691 st019933 84.6 µM 0.47201832331661 0.317563357018666 no 1035 0.318456854933235 380 6176082
SGTC_126 0417-1624 672.48 µM 0.471057650557087 0.317915308758339 no 1036 0.318799783179432 388 41912 YDL195W SEC31
SGTC_825 1988-2224 89.6 µM 0.469675981963164 0.318421784839344 no 1037 0.319293265043067 341 1180859
SGTC_1378 2093-0007 380 nM 0.469644800201769 0.3184332190099 no 1038 0.319304405735372 387 3618014
SGTC_1929 genistein trimethyl ether 50.5 µM 0.467022807906306 0.3193953061388 no 1039 0.320241780058064 344 136420
SGTC_2766 oltipraz 83.91 µM 0.466723121654868 0.31950534758675 no 1040 0.32034899250808 338 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2877 9040724 71.43 µM 0.465541388100768 0.319939421813205 no 1041 0.320771902569103 350 6463895
SGTC_1507 4075-3230 155 µM 0.463361992955572 0.320740603560225 no 1042 0.321552458412879 371 659771
SGTC_1210 3013-0140 750 nM 0.462347891124158 0.321113689330143 no 1043 0.321915930566949 361 905973
SGTC_1414 3917-0015 5.4 µM 0.460032356477294 0.321966245966211 no 1044 0.322746497911216 363 6618702
SGTC_1529 apigenin 74 µM 0.459878056604708 0.322023091012148 no 1045 0.322801875778345 368 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1865 st057639 52.2 µM 0.459305114826577 0.322234202807055 no 1046 0.323007537634657 360 688818
SGTC_2300 7976697 71.57 µM 0.459286293234273 0.322241138970555 no 1047 0.323014294708498 332 2236109
SGTC_2490 carminic acid 95.39 µM 0.458574777016857 0.322503393453731 no 1048 0.323269776474883 331 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2374 9071832 200 µM 0.457645509000295 0.322846041095166 no 1049 0.32360357119182 361 17381698
SGTC_656 4090-1979 187 µM 0.456652989275567 0.323212177603696 no 1050 0.323960242838905 366 22330961
SGTC_1704 st028805 70.8 µM 0.456593255297272 0.323234218695496 no 1051 0.32398171398814 348 2876101
SGTC_2294 7971431 200 µM 0.456169294820991 0.323390672642502 no 1052 0.324134121778733 394 5741572
SGTC_90 0870-0863 4.608 µM 0.456145290998671 0.323399531696943 no 1053 0.324142751695064 379 1738164
SGTC_580 1123-0028 41 µM 0.454636318750449 0.323956646609827 no 1054 0.324685450818985 356 1677248 YPR107C YTH1
SGTC_474 dl-dihydrosphingosine 5 µM 0.451590092998317 0.32508251920672 no 1055 0.32578215418158 322 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2102 5377816 72.7585 µM 0.451443899250826 0.32513659210982 no 1056 0.325834824940732 376 1379702
SGTC_1609 st001574 46.4 µM 0.450863718672237 0.325351220679981 no 1057 0.326043886964721 396 3960012
SGTC_245 methotrexate 289.6 µM 0.450772151384385 0.325385099836185 no 1058 0.326076887281131 342 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_722 3534-0461 190 µM 0.450427093721396 0.32551278134462 no 1059 0.326201256286352 330 658262
SGTC_2539 epi(13)torulosol 80 µM 0.450013764975609 0.325665752123014 no 1060 0.326350257658445 336 6708597
SGTC_2788 5282734 71.43 µM 0.448021936308287 0.326403328651351 no 1061 0.327068682606609 371 743706
SGTC_278 4092-0821 23.9 µM 0.447601170544714 0.326559225718821 no 1062 0.327220529110075 349 877900
SGTC_1428 4049-0204 61.7 µM 0.445792587478582 0.327229664833704 no 1063 0.327873538355873 370 X1428
SGTC_1143 3454-2408 5.08 µM 0.445527193640871 0.327328092926047 no 1064 0.327969406140447 344 X1143
SGTC_1423 4048-0112 5.59 µM 0.444057118278788 0.327873525269357 no 1065 0.328500644234474 362 X1423
SGTC_890 0929-0006 47.2 µM 0.443178477251224 0.328199697127171 no 1066 0.328818322616172 338 1378169
SGTC_1321 1326-2144 215 µM 0.443048442626113 0.328247980122021 no 1067 0.328865347996317 381 3513030
SGTC_2213 7173844 200 µM 0.443030380790179 0.328254686866818 no 1068 0.328871880045515 355 892728
SGTC_3122 9126309 49.47 µM 0.44201720602834 0.328630988850391 no 1069 0.32923837757739 409 17591206
SGTC_2654 protoveratrine a 100 µM 0.441306416724506 0.328895086014288 no 1070 0.329495590676347 379 5702278 A heart drug and vasodilator.
SGTC_2200 6600604 21.907 µM 0.438760614851856 0.329841691223704 no 1071 0.330417500541416 386 2904777
SGTC_869 0564-0080 44.1 µM 0.436155879467668 0.330811338830217 no 1072 0.331361818328408 336 6843321
SGTC_2520 obtusaquinone 4.71 µM 0.436043987851924 0.330853017480969 no 1073 0.331402407469762 389 5967872
SGTC_2036 5160441 105 µM 0.435399979754729 0.331092945629644 no 1074 0.331636062530529 365 134534 YIL048W NEO1
SGTC_2264 7948757 110.76 µM 0.434450167263314 0.331446929183891 no 1075 0.331980787225951 336 2971411
SGTC_1707 st032323 6.317 µM 0.429451745761847 0.333312255778052 no 1076 0.333797251615286 344 3132057 YMR211W DML1
SGTC_1334 1486-0610 236 µM 0.429243231273206 0.333390159918897 no 1077 0.333873112436462 355 3742339
SGTC_1396 3511-0007 98.6 µM 0.428140931385248 0.333802115047241 no 1078 0.334274259081377 384 X1396
SGTC_2471 5466956 24.79 µM 0.427771160017699 0.333940352129683 no 1079 0.334408867931013 357 724419
SGTC_99 0109-0120 622.8 µM 0.427106676609127 0.334188822388037 no 1080 0.334650815088996 381 759414
SGTC_3218 9131285 49.47 µM 0.426686504772476 0.334345974745607 no 1081 0.33480384063483 381 17156417
SGTC_114 0364-0001 490.298 µM 0.426324049402732 0.334481563362843 no 1082 0.334935868029363 347 4003655
SGTC_888 0916-0002 6.97 µM 0.425989059506726 0.334606896797175 no 1083 0.335057909038499 350 2802138 YIL048W NEO1
SGTC_2311 7694451 200 µM 0.425390389253577 0.334830929745497 no 1084 0.335276055468555 405 2163142
SGTC_2642 cholecalciferol 100 µM 0.422465353335282 0.335926373874947 no 1085 0.336342692262114 366 9821465 A vitamin D precursor, similar to steriods.
SGTC_2830 7992007 71.43 µM 0.422257421273742 0.336004298949635 no 1086 0.336418566582605 342 1952075
SGTC_956 1185-0240 191 µM 0.42198318294806 0.336107083884352 no 1087 0.336518646217656 355 1416193
SGTC_44 0929-0055 61.211 µM 0.42197494554542 0.336110171464808 no 1088 0.336521652527563 343 1379590
SGTC_1978 st071761 42 µM 0.421895382856924 0.336139994080136 no 1089 0.336550690142917 351 5147680
SGTC_1427 4048-4900 550 nM 0.420777387874823 0.336559162999536 no 1090 0.336958822454352 375 24132586
SGTC_2588 indole-3-carbinol 100 µM 0.419235359989865 0.337137647531319 no 1091 0.337522066127064 402 3712 Induces cell cycle arrest.
SGTC_151 3013-0144 2.285 µM 0.418803726458056 0.337299641909002 no 1092 0.33767979060398 398 906558 YHR107C CDC12
SGTC_3275 9138069 49.47 µM 0.416597485039109 0.338128126749626 no 1093 0.33848642460301 391 17617007
SGTC_1518 st038567 90.8 µM 0.416305829474186 0.338237707654431 no 1094 0.338593113703947 383 77966
SGTC_171 k064-0041 9.68 µM 0.416011049665441 0.338348476325941 no 1095 0.338700958832921 349 53325
SGTC_1344 1488-0097 29.1 µM 0.415920182439447 0.338382624097669 no 1096 0.338734205255034 376 747966
SGTC_2696 st077691 74.316 µM 0.415327683099049 0.338605317068885 no 1097 0.338951019199655 400 757133
SGTC_596 1155-0152 116 µM 0.41526899487413 0.338627378319109 no 1098 0.338972497952797 369 280313
SGTC_874 0599-0792 117 µM 0.414012875893903 0.339099693507167 no 1099 0.339432338563851 390 765305
SGTC_961 1252-1571 372 µM 0.413843989383261 0.339163216088035 no 1100 0.339494182870695 395 6813498
SGTC_445 e6 berbamine 66 µM 0.413095895063805 0.339444648652207 no 1101 0.33976817840729 364 6610268 A calcium/calmodulin antagonist.
SGTC_970 1315-0089 19.5 µM 0.412491731427855 0.339671999978966 no 1102 0.339989519998488 356 6811083 YLR033W RSC58
SGTC_2492 derrusnin 100 µM 0.41135422781046 0.340100209445023 no 1103 0.340406405864784 416 1715307 Part of coumarin class of compounds.
SGTC_1989 st071868 50.2 µM 0.409965575631394 0.340623242624005 no 1104 0.340915600088569 386 16414057
SGTC_1282 0886-0010 32.4 µM 0.409025944547633 0.340977326866806 no 1105 0.341260310742733 398 2836211 YNL267W PIK1
SGTC_1241 0364-0022 50.8 µM 0.40833718296112 0.341236964155876 no 1106 0.341513072234274 378 4563895
SGTC_2512 diallyl trisulfide 49.23 µM 0.407423601616552 0.341581466040808 no 1107 0.341848447683962 399 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2154 5570129 200 µM 0.406223720676581 0.342034129001079 no 1108 0.342289113272549 390 673366
SGTC_2568 diosmetin 100 µM 0.405364297767441 0.342358491585944 no 1109 0.342604875087824 389 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1650 st011916 45.8 µM 0.405081225845329 0.342465353801485 no 1110 0.342708903049758 396 242528
SGTC_1569 carminic acid 40.6 µM 0.404489326544477 0.342688841899502 no 1111 0.342926462558209 369 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2564 betulinic acid 100 µM 0.402292956282133 0.343518623587407 no 1112 0.343734218926012 364 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1512 0259-0544 12.2 µM 0.402040348574575 0.343614106439091 no 1113 0.343827165994842 372 18476
SGTC_1056 3448-1962 115 µM 0.400597984191182 0.344159494832607 no 1114 0.344358065016295 377 715507
SGTC_1813 st051246 8.6015 µM 0.40054629566554 0.344179045379984 no 1115 0.344377095997916 364 5291959
SGTC_1462 k081-0014 26.5 µM 0.398536946423846 0.344939379278235 no 1116 0.345117214832238 351 3270634
SGTC_266 formosanin C 406 nM 0.398442347430353 0.344975190822843 no 1117 0.345152073830496 355 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2460 5552655 174.22 µM 0.395669266623332 0.346025588489321 no 1118 0.34617451538389 354 5401989
SGTC_3222 9128301 49.47 µM 0.394466519768101 0.346481538540229 no 1119 0.346618320421599 367 4911358
SGTC_1498 4478-3555 97.6 µM 0.393147613540903 0.346981779313702 no 1120 0.34710522952468 374 3437919
SGTC_385 1494-0393 12.4 µM 0.39313334542227 0.346987192451143 no 1121 0.34711049835997 379 3090647
SGTC_1719 st032227 49.2 µM 0.393036756700535 0.347023837768969 no 1122 0.347146166773425 353 3125804
SGTC_895 0964-0006 13.7 µM 0.391832454172633 0.347480864650303 no 1123 0.347591006841163 391 6738897
SGTC_2705 st078069 42.8 µM 0.387797897251773 0.349013572109543 no 1124 0.349082800871306 371 1530061
SGTC_714 4296-0578 26.1 µM 0.385290276730478 0.349967448985981 no 1125 0.350011182291375 377 1589775
SGTC_257 daunorubicin 18.5 µM 0.384475221545194 0.35027769318046 no 1126 0.35031312880693 397 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1197 1601-0112 267 µM 0.384352298122167 0.35032449166902 no 1127 0.350358675411652 365 7350313
SGTC_1483 3453-0561 55.9 µM 0.383713562816272 0.350567702778565 no 1128 0.350595379536594 381 4546991
SGTC_848 0368-0089 85.6 µM 0.382485934319121 0.351035318590556 no 1129 0.351050480021597 415 762535
SGTC_2461 5755302 26.15 µM 0.382367205602802 0.351080555509907 no 1130 0.351094505900655 394 2788904
SGTC_264 promethazine 12.5 mM 0.381731418392521 0.351322833178534 no 1131 0.35133029660047 410 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_3172 9105863 49.47 µM 0.38113451506219 0.351550348475694 no 1132 0.351551718753605 385 2348785
SGTC_3047 9092122 49.47 µM 0.380333039486688 0.35185592204747 no 1133 0.35184910650199 383 17173831
SGTC_1181 1222-0449 220 µM 0.379462344639033 0.352187994890456 no 1134 0.352172280825819 379 658318
SGTC_1742 st038235 28.8875 µM 0.377300103156772 0.353013135674212 no 1135 0.352975297766504 420 564103 YBR002C RER2
SGTC_307 1501-1223 22.3 µM 0.377069790620961 0.353101066902117 no 1136 0.353060870308506 396 2830329
SGTC_2333 9017922 200 µM 0.376862903727233 0.353180061121722 no 1137 0.353137745397874 383 3163164
SGTC_165 k038-0023 64.381 µM 0.376197374200917 0.353434218644606 no 1138 0.353385083684763 379 46368543
SGTC_2452 5863136 48.41 µM 0.376165556047507 0.353446371243365 no 1139 0.353396910178046 383 2184096
SGTC_2234 tolnaftate 200 µM 0.376048876216888 0.353490937118174 no 1140 0.353440280129592 410 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2070 5230947 200 µM 0.375468598311803 0.353712604154068 no 1141 0.353655997973577 422 2835538
SGTC_2694 st077685 81.9 µM 0.374405030989419 0.35411901722313 no 1142 0.35405150025439 351 2838096
SGTC_79 0052-0007 94.094 µM 0.37390977573934 0.354308322182646 no 1143 0.354235721574808 402 2801472
SGTC_620 0109-0052 432 µM 0.373380565354445 0.354510645847873 no 1144 0.354432610976002 381 493037
SGTC_3039 9090270 49.47 µM 0.373024866814295 0.3546466568688 no 1145 0.354564968252107 375 17173750
SGTC_2713 st079149 53.4 µM 0.372510931151646 0.354843206892385 no 1146 0.354756237400831 374 3103253
SGTC_1572 epiandrosterone 68.9 µM 0.371785070763091 0.35512087142259 no 1147 0.355026440008034 386 441302 A steroid.
SGTC_2073 5212005 126 µM 0.37074027089522 0.355520675444641 no 1148 0.35541549631233 422 691789
SGTC_2395 5646831 180.19 µM 0.370240865642183 0.355711834492644 no 1149 0.355601515108582 402 6808628
SGTC_588 3970-1144 52.9 µM 0.368965498405388 0.356200175734311 no 1150 0.356076720729818 378 1888707
SGTC_1630 st005209 31.3 µM 0.368354699304082 0.356434135818037 no 1151 0.356304385541059 403 3367314
SGTC_1254 0550-0035 264 µM 0.36831203580557 0.356450479636448 no 1152 0.356320289537892 405 15121435
SGTC_735 3076-0345 636 µM 0.368150048258635 0.35651253731016 no 1153 0.356380677143408 370 2888990
SGTC_2190 6049624 200 µM 0.368039907763489 0.356554734469954 no 1154 0.356421738657637 396 2265554
SGTC_1986 st071812 45 µM 0.367836391013347 0.356632710673158 no 1155 0.356497616183317 394 11838594
SGTC_3159 9100096 49.47 µM 0.367740878721592 0.356669307692206 no 1156 0.356533228166061 362 25236875
SGTC_1682 st012968 530 nM 0.367239205333543 0.356861553307704 no 1157 0.356720298802175 364 24207270
SGTC_2059 5238311 157 µM 0.36643944893647 0.3571681020952 no 1158 0.357018593845628 373 703021
SGTC_738 1315-0003 72.4 µM 0.365415574062495 0.357560690686586 no 1159 0.357400608726068 408 6251474
SGTC_821 1114-0266 29.2 µM 0.364987702779922 0.357724795839576 no 1160 0.357560292867896 394 3123235
SGTC_3167 9103034 49.47 µM 0.364271515363633 0.357999540207065 no 1161 0.35782763412523 374 5127859
SGTC_2883 9059145 45.46 µM 0.363381490664161 0.358341074670865 no 1162 0.358159963241039 412 16476510
SGTC_2217 6934799 96.0675 µM 0.363178608308609 0.358418943797344 no 1163 0.358235733173902 387 675606
SGTC_2887 9044784 58.44 µM 0.362783696134963 0.358570533574161 no 1164 0.358383235979662 405 6465546
SGTC_3197 9113331 49.47 µM 0.361941971308199 0.358893709833705 no 1165 0.358697697331603 352 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_3304 9125678 46.087 µM 0.3617326460639 0.358974094965209 no 1166 0.358775914375887 378 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.359475315718983 0.359841351659472 no 1167 0.359619770319653 362 6708739 YPR165W RHO1
SGTC_223 busulfan 5 mM 0.358703445193079 0.360138066928318 no 1168 0.359908475398024 397 2478 A DNA alkylator.
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.356769751108353 0.360881769261799 no 1169 0.360632091553727 394 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_629 3448-6466 76.7 µM 0.356401434366326 0.361023484323019 no 1170 0.360769977669908 406 573744
SGTC_67 0335-0847 266 µM 0.355663654850652 0.361307412767107 no 1171 0.361046233368579 411 4552207 YOR254C SEC63
SGTC_1761 st044296 37 µM 0.354884952444471 0.361607172939033 no 1172 0.361337890959942 370 1826700
SGTC_2437 5741531 144.16 µM 0.354274227001383 0.361842330116955 no 1173 0.361566690354197 413 2262990
SGTC_1694 st024011 44.9 µM 0.353861665406121 0.362001214700113 no 1174 0.361721278571907 409 2787533
SGTC_1927 st060202 13.8 µM 0.35184470945246 0.36277832113337 no 1175 0.362477363215715 384 688887
SGTC_3339 9145883 14.936 µM 0.34890073908608 0.363913608361833 no 1176 0.363581915148558 410 2030670
SGTC_1922 5578187 25 µM 0.3481747803899 0.364193744931624 no 1177 0.363854463295198 388 1350412
SGTC_1564 D-Arginine 115 µM 0.347503096575373 0.364453002282503 no 1178 0.364106696279788 393 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1304 1165-0502 251 µM 0.347452023794436 0.364472717956399 no 1179 0.364125877713785 368 767425
SGTC_600 1495-0418 41.6 µM 0.347272971855831 0.364541840377015 no 1180 0.364193127042516 381 5377768
SGTC_2571 chrysanthemic acid 100 µM 0.345488116469174 0.365231118473075 no 1181 0.364863721309124 404 2743 An insecticide.
SGTC_1193 1488-0126 41.5 µM 0.345486949992349 0.365231569087493 no 1182 0.364864159705677 377 1384710
SGTC_1440 4100-1550 40 µM 0.345154063216312 0.365360172111679 no 1183 0.364989275636847 411 742806
SGTC_1736 st036774 51 µM 0.34435138615543 0.365670329872541 no 1184 0.365291021964528 407 1272247
SGTC_508 roscovitine 141 µM 0.344086084771335 0.365772862756924 no 1185 0.365390773721913 410 160355 A CDKinase inhibitor.
SGTC_504 lovastatin 124 µM 0.34379237868685 0.365886384589124 no 1186 0.365501216100116 415 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2480 5767542 37.17 µM 0.343700712901339 0.365921817203004 no 1187 0.365535687494057 408 2867358
SGTC_41 0478-0632 82.643 µM 0.342060891336368 0.366555868958212 no 1188 0.366152534148413 434 3750424
SGTC_1887 st057648 70.8 µM 0.342000569169647 0.366579200025124 no 1189 0.366175231961951 409 688672
SGTC_1975 st070967 30.8 µM 0.341656557702114 0.366712264258196 no 1190 0.36630468433939 431 261391
SGTC_977 1348-1378 135 µM 0.341415212035714 0.366805626743942 no 1191 0.366395512401379 410 X977
SGTC_2203 7227154 166.4 µM 0.341401702853966 0.366810852887104 no 1192 0.366400596669973 386 896304
SGTC_1432 4049-0298 68.4 µM 0.341219048126856 0.36688151686256 no 1193 0.366469342268492 427 741646
SGTC_1298 1079-1278 263 µM 0.341203405532443 0.366887568752014 no 1194 0.366475229857167 406 2840950
SGTC_831 k061-1017 217 µM 0.341197259172702 0.366889946697151 no 1195 0.366477543244036 422 1240153
SGTC_773 4358-1457 44.6 µM 0.341038275178077 0.366951457272445 no 1196 0.366537383842503 413 1186886
SGTC_1228 0124-0032 52.5 µM 0.339490531767081 0.367550454240837 no 1197 0.367120114293741 398 X1228
SGTC_622 1348-1566 26.3 µM 0.338961531615496 0.367755258222043 no 1198 0.367319354870819 400 7340407
SGTC_2104 5389443 200 µM 0.338688368715851 0.367861028778305 no 1199 0.367422251883367 400 2244536
SGTC_1777 st045864 34.765 µM 0.336749511277512 0.368612055283032 no 1200 0.36815286817717 424 4691462
SGTC_1080 nisoldipine 24.4 µM 0.335038356101247 0.369275297408546 no 1201 0.368798076311941 425 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1333 1482-0047 286 µM 0.333636717612116 0.369818861315701 no 1202 0.369326853834152 423 3811116
SGTC_584 0986-0246 15.4 µM 0.332074854508069 0.370424867805547 no 1203 0.369916368485993 427 53315 YDR232W HEM1
SGTC_485 niflumic acid 177 µM 0.33159899332366 0.370609567052869 no 1204 0.370096039911451 407 4488 A COX2 inhibitor.
SGTC_1349 flufenamic acid 69 µM 0.328711085243849 0.371731108851003 no 1205 0.371187037366744 402 3371 A non-steroidal anti-inflammatory.
SGTC_948 3448-0295 75.3 µM 0.327865614129141 0.372059660808356 no 1206 0.371506636922581 385 678569
SGTC_1879 gemcitabine 100 µM 0.327555595439401 0.372180158120374 no 1207 0.371623850407332 415 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1848 st056003 16.4 µM 0.326806205749711 0.372471480763273 no 1208 0.371907232716913 405 146492
SGTC_2560 caryophyllene 100 µM 0.326230685488567 0.372695261825717 no 1209 0.372124913292901 386 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_481 bay k-8644 50 µM 0.322240807891692 0.374247834381331 no 1210 0.373635135831419 402 2303 A calcium channel antagonist.
SGTC_1684 st024538 14.6195 µM 0.322189931700146 0.37426764496091 no 1211 0.373654405748107 388 6732859
SGTC_1307 1187-1599 12.2 µM 0.320440540118431 0.374949038733593 no 1212 0.374317198898339 402 1538471
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.319558306686746 0.375292819824864 no 1213 0.374651592352106 382 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1859 st055998 20 µM 0.317542349725522 0.376078751941901 no 1214 0.375416055208886 400 676301
SGTC_1335 1486-0900 202 µM 0.317289542925642 0.376177346442214 no 1215 0.375511955650141 397 X1335
SGTC_1192 1488-0095 21.4 µM 0.316132470464644 0.376628707058568 no 1216 0.37595098086098 410 915875
SGTC_677 0929-0063 136 µM 0.312463084801574 0.378061205242064 no 1217 0.377344306824453 408 1539583
SGTC_2110 5483698 200 µM 0.311694591647385 0.378361431874559 no 1218 0.377636319292128 372 2848765 YHR062C RPP1
SGTC_2665 lovastatin 100 µM 0.31129815166299 0.378516337509341 no 1219 0.37778698614579 405 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2419 paclitaxel 166.5 µM 0.310707361386794 0.378747220127301 no 1220 0.378011550245425 408 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2029 5175081 200 µM 0.30873837254589 0.379517018955922 no 1221 0.378760275878047 378 1380876
SGTC_2762 leflunomide 42.06 µM 0.306503409205817 0.380391382502351 no 1222 0.379610692247848 407 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1501 4491-0275 38.4 µM 0.30468135192189 0.38110466141872 no 1223 0.380304426876083 439 5104718
SGTC_3066 9117245 49.47 µM 0.304059031688683 0.3813483732021 no 1224 0.380541458993851 415 17176980
SGTC_352 k048-0007 5.11 µM 0.303593229756853 0.381530820405867 no 1225 0.38071890507676 436 6811911
SGTC_1316 1272-0050 65.9 µM 0.301583993907528 0.382318107331087 no 1226 0.381484605602158 420 7340392
SGTC_2837 9008476 45.46 µM 0.300509521980091 0.382739321924807 no 1227 0.381894267195747 425 2992805
SGTC_1147 3809-1045 12.3 µM 0.298992728703223 0.383334171439173 no 1228 0.382472796794524 407 325925
SGTC_2870 9038528 12.99 µM 0.297827529518384 0.38379132123524 no 1229 0.382917400990079 416 6463316
SGTC_2136 5328288 199.296 µM 0.296826356192772 0.384184247001753 no 1230 0.383299541240925 402 262395
SGTC_2307 7538926 6.34 µM 0.296801120521938 0.384194152666269 no 1231 0.383309174973718 402 96582
SGTC_570 0987-0065 62.6 µM 0.296664445911321 0.384247802359592 no 1232 0.383361351843527 433 3104428
SGTC_919 tnp00227 403.569 nM 0.29560349810615 0.384664337828302 no 1233 0.383766450933073 430 1269246 A methoxyflavone. YNL221C POP1
SGTC_2048 5246248 200 µM 0.295055060381271 0.384879710530331 no 1234 0.383975909406022 414 677046
SGTC_292 k038-0015 474 µM 0.294588632283919 0.38506290582864 no 1235 0.384154073566336 395 46368540
SGTC_2924 9010168 62.78 µM 0.292710909454243 0.385800663433082 no 1236 0.3848715652088 397 2993929
SGTC_163 TUB2.036 7.546 µM 0.291923504858183 0.38611015797001 no 1237 0.385172555793402 418 15992207 YJR013W GPI14
SGTC_2241 6772625 37.8075 µM 0.290588892031052 0.38663490175877 no 1238 0.385682878265407 439 2285411
SGTC_100 0086-0128 49.5915 µM 0.289834279894073 0.386931692390657 no 1239 0.385971510679259 429 93297
SGTC_3112 9123419 49.47 µM 0.28928581446241 0.387147446572401 no 1240 0.386181333444468 442 17015854
SGTC_904 1141-0088 396 µM 0.28892337090434 0.387290042999011 no 1241 0.386320009335233 421 1378119
SGTC_1329 1447-1697 50.6 µM 0.286806183159272 0.388123313009964 no 1242 0.387130364139946 394 2840515
SGTC_2017 5132927 60.65 µM 0.286754493290529 0.388143663256938 no 1243 0.387150154635212 404 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_815 1582-0027 36.9 µM 0.286596063941932 0.388206038638022 no 1244 0.387210814292463 421 3128206
SGTC_3316 9136639 10.545 µM 0.284904233974892 0.388872310267475 no 1245 0.387858756059273 436 4903665
SGTC_2585 alliin 100 µM 0.28414029050976 0.389173271571654 no 1246 0.388151435740687 442 87310 A garlic compound which reacts with lipids.
SGTC_2722 naftopidil 47.16 µM 0.283845973306958 0.389289237814567 no 1247 0.388264210609587 433 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_719 2810-4230 27.3 µM 0.283488200432763 0.389430220005754 no 1248 0.388401312765183 429 721079
SGTC_941 3237-0776 460 µM 0.282963531614317 0.389636994695718 no 1249 0.388602396266692 449 760008
SGTC_23 0213-0011 39.996 µM 0.282811391404559 0.389696959783935 no 1250 0.388660710799364 407 627608
SGTC_534 k292-0788 63.4 µM 0.281258229274292 0.390309278676933 no 1251 0.389256172917343 432 4146317
SGTC_721 1187-1332 279 µM 0.280695977783526 0.390531007982789 no 1252 0.389471797020947 436 25730
SGTC_3127 9126946 49.47 µM 0.280514631565212 0.390602531212941 no 1253 0.389541350769181 434 27243249
SGTC_645 0845-0943 5.41 µM 0.278604126711097 0.391356261779398 no 1254 0.390274322702501 410 1885106
SGTC_2359 9039622 200 µM 0.278589961372531 0.391361851803089 no 1255 0.390279758745167 426 6463596
SGTC_1111 tnp00062 510.699 nM 0.27850203273413 0.391396551311228 no 1256 0.390313502423411 402 676306
SGTC_2781 5567276 71.43 µM 0.278469409337989 0.391409425787057 no 1257 0.390326022256354 412 2853274
SGTC_1049 3226-0134 66 µM 0.276043289540452 0.392367200591811 no 1258 0.391257408599488 404 5702385
SGTC_3355 9151058 44.0485 µM 0.276033399659449 0.392371106222208 no 1259 0.391261206600947 408 17015728
SGTC_3044 9093193 49.47 µM 0.275779851656552 0.392471239013011 no 1260 0.391358579935141 442 25236277
SGTC_2251 lansoprazole 556 µM 0.274288272700442 0.393060446785574 no 1261 0.39193154804093 428 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2321 7390090 138.78 µM 0.273596091558246 0.393333957490856 no 1262 0.392197518960079 413 649046
SGTC_2603 homopterocarpin 100 µM 0.272721118909185 0.393679772355121 no 1263 0.392533799668573 410 101795 A weak amylase inhibitor.
SGTC_1098 clofazimine 15.1 µM 0.272628713193837 0.393716298706419 no 1264 0.39256931890755 419 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2380 9035439 200 µM 0.272586931613479 0.393732814536075 no 1265 0.392585379354457 409 6462575
SGTC_2121 5257820 149.641 µM 0.272174442281642 0.393895877588208 no 1266 0.392743946190691 448 791256
SGTC_3336 9143619 71.43 µM 0.272101934171087 0.393924543025793 no 1267 0.392771821192514 423 45595730
SGTC_421 streptovitacin 30 mM 0.272064502706444 0.393939341447862 no 1268 0.392786211551668 414 91467 include heat shock
SGTC_2994 9053520 71.4286 µM 0.270449120983538 0.394578123616986 no 1269 0.393407377209245 443 4647384
SGTC_1239 0337-0584 35.4 µM 0.269853059318341 0.394813900339349 no 1270 0.39363665051667 429 914301 YML130C ERO1
SGTC_1628 st004252 77.7 µM 0.269566204250391 0.394927381779927 no 1271 0.393747001596634 400 692968
SGTC_226 1,3-diallylurea 8.28947 mM 0.268701176881816 0.395269645294054 no 1272 0.394079823030853 413 74537 YKL182W FAS1
SGTC_362 0310-0100 9.03 µM 0.268320250729497 0.395420391167397 no 1273 0.394226409866826 394 790235
SGTC_1959 st077091 55.8 µM 0.268199882713498 0.395468028278808 no 1274 0.394272732634575 418 821356 YKL052C ASK1
SGTC_3186 9110464 49.47 µM 0.267944821619104 0.395568976980587 no 1275 0.394370896008707 430 17018021
SGTC_1035 k081-0041 55.2 µM 0.267620172516193 0.395697477528347 no 1276 0.394495850880386 456 731709
SGTC_2489 cantharidin 73.42 µM 0.266397468026331 0.396181542317544 no 1277 0.394966557510109 445 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1939 st074455 53.6 µM 0.265210317391666 0.396651684659717 no 1278 0.395423723640089 457 1644229
SGTC_2109 5483026 200 µM 0.263254125482718 0.397426714788084 no 1279 0.396177357719057 452 759335
SGTC_149 3970-0822 46.1 µM 0.262846837903045 0.397588130455542 no 1280 0.396334316495791 420 3114250 YBL034C STU1
SGTC_806 3966-4455 5.86 µM 0.262439773425916 0.397749475226011 no 1281 0.396491206084407 422 714982
SGTC_526 4469-0568 170 µM 0.261060099590442 0.398296455054439 no 1282 0.397023080434492 415 2901964
SGTC_2155 5570423 76 µM 0.260943917494736 0.398342525271705 no 1283 0.397067878241741 433 797402
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.260295132168264 0.398599817114285 no 1284 0.39731806359801 436 6708760
SGTC_328 k915-0120 63.5 µM 0.259745982793317 0.398817630309793 no 1285 0.397529860244559 420 6624543
SGTC_520 3584-0023 682 µM 0.259686061510397 0.398841399241557 no 1286 0.397552972592326 389 1340790
SGTC_3058 9093861 49.47 µM 0.258707336880345 0.399229682275387 no 1287 0.397930529116855 443 17217477
SGTC_459 nigericin 15.3 µM 0.258508274162537 0.399308667343436 no 1288 0.398007332017377 442 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3342 9147791 14.508 µM 0.257904615854434 0.399548214997335 no 1289 0.398240261204932 439 1838168
SGTC_46 0329-0187a 2.197 µM 0.257901494266039 0.399549453824907 no 1290 0.398241465803589 436 46494817
SGTC_359 0081-0058 15.9 µM 0.256490482883437 0.400109528452215 no 1291 0.398786064136944 472 3494159
SGTC_1202 1988-0068 29.6 µM 0.256038837867046 0.400288843985491 no 1292 0.398960424146135 406 2850480
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.255753281108094 0.400402228747385 no 1293 0.39907067528915 454 140250 A respiratory chain inhibitor.
SGTC_835 0312-0010 67.2 µM 0.255454969212804 0.400520687099884 no 1294 0.399185859686174 411 1626196
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.254163145194689 0.401033770260865 no 1295 0.399684760866209 422 688803
SGTC_1072 oxiconazole 14.9 nM 0.253763236008946 0.401192639757786 no 1296 0.399839238650524 422 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2475 5812728 15.03 µM 0.252879048985915 0.401543953334171 no 1297 0.400180839941281 416 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1141 3253-0389 52.6 µM 0.252181453047702 0.401821184956885 no 1298 0.400450406608648 459 5402031
SGTC_2553 4-methylesculetin 85.09 µM 0.252098227084486 0.40185426309128 no 1299 0.400482570150617 413 5319502
SGTC_259 usnic acid 108.925 µM 0.251138892001208 0.402235601239609 no 1300 0.40085336387315 456 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2757 clomiphene 4.22 µM 0.251029897158276 0.402278932862663 no 1301 0.400895497255158 462 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_739 1486-1183 203 µM 0.250950734052213 0.402310405433645 no 1302 0.400926099511871 451 4346692
SGTC_1829 berberine 14.4 µM 0.250273791443728 0.40257956073928 no 1303 0.401187811519538 439 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_871 0574-0004 149 µM 0.249945923614364 0.402709939014195 no 1304 0.401314584072604 428 9551173
SGTC_1434 4073-0095 163 µM 0.249788955374978 0.402772362047279 no 1305 0.401375280696994 441 24133745
SGTC_1937 st074714 47.2 µM 0.24956026231732 0.402863312997846 no 1306 0.401463716199802 425 17250970
SGTC_690 glyoxal 20.3 µM 0.249202903123664 0.403005444836809 no 1307 0.401601916943904 425 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_486 niguldipine 82 µM 0.248248213483199 0.403385214665474 no 1308 0.401971182309431 432 1236 A calcium channel blocker.
SGTC_1796 st049173 110.4 µM 0.246636195404406 0.404026672490569 no 1309 0.402594894906728 451 94134
SGTC_1921 5740136 50 µM 0.245720644104013 0.404391105765021 no 1310 0.402949245190024 460 1774243
SGTC_1112 tnp00069 1.16933 µM 0.245302235800766 0.404557679955526 no 1311 0.403111210355496 444 145826
SGTC_3331 9141060 1.957 µM 0.244528087144718 0.404865924946045 no 1312 0.403410925840815 418 4906567 YPR165W RHO1
SGTC_1556 plumbagin 1.48 µM 0.243795991876034 0.405157479739754 no 1313 0.403694412353858 441 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_372 0155-0182 15.9 µM 0.243238204389695 0.405379652314777 no 1314 0.403910436287845 427 771486
SGTC_550 4123-0385 25.7 µM 0.242581261648314 0.405641358561812 no 1315 0.404164899364545 435 5731123
SGTC_703 3875-0075 71.8 µM 0.241689198253781 0.405996797322971 no 1316 0.404510500008751 457 2850814
SGTC_2544 sphondin 68.51 µM 0.241232148760405 0.406178936740293 no 1317 0.404687597701333 436 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_3345 9148410 3.559 µM 0.240487489541293 0.406475735379647 no 1318 0.404976180317219 452 4903596
SGTC_2764 methyldopa 94.69 µM 0.240129803241175 0.406618317435551 no 1319 0.40511481519307 448 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_123 0083-0120 66.675 µM 0.239822204413772 0.406740943365463 no 1320 0.405234046295546 442 16001701
SGTC_1191 1487-1166 10.6 µM 0.239591607583706 0.406832878032292 no 1321 0.40532343574191 459 3955771
SGTC_2355 9061122 103.12 µM 0.238721105114984 0.407179977409672 no 1322 0.405660925158248 442 5302957
SGTC_3050 9093513 49.47 µM 0.236629472722743 0.408014280979565 no 1323 0.406472126764024 440 25236664
SGTC_378 3970-0959 8.33 µM 0.236194769353422 0.408187726548641 no 1324 0.406640769080714 445 6615653
SGTC_1043 0916-0009 19.3 µM 0.235802585570557 0.408344222346056 no 1325 0.406792930866752 463 3101130
SGTC_1302 1159-0335 255 µM 0.235528975691436 0.408453411440484 no 1326 0.40689909598238 426 649284
SGTC_1774 st048371 48.465 µM 0.234902245601501 0.408703546473951 no 1327 0.407142303297672 442 4242727
SGTC_3018 9082602 49.47 µM 0.232671509371448 0.409594159523355 no 1328 0.408008247155115 439 17332089
SGTC_507 nimesulide 162 µM 0.232244419567274 0.409764726895068 no 1329 0.408174089467636 462 4495 A COX2 inhibitor.
SGTC_1068 loratadine 26.9 µM 0.231827043753779 0.409931431279039 no 1330 0.408336175655382 432 3957 A H1 histamine antagonist.
SGTC_2996 9066192 71.4286 µM 0.230754801923708 0.410359770756206 no 1331 0.408752648216556 430 6472854
SGTC_1656 st012921 11 µM 0.230677301889785 0.410390734643009 no 1332 0.408782754228745 454 6732821
SGTC_179 1273-0063 6.77 µM 0.230096859428861 0.410622658799063 no 1333 0.409008252620364 454 3108139
SGTC_275 trichlorophene 5.69 µM 0.229863858839206 0.410715766340722 no 1334 0.409098780418578 447 62616
SGTC_460 trequinsin 123 µM 0.229295666532127 0.410942838305137 no 1335 0.409319560687922 450 5537 A vasodilator.
SGTC_785 1270-0111 65.3 µM 0.229208927308048 0.410977505333946 no 1336 0.409353267142573 417 6741994
SGTC_2064 5220758 200 µM 0.228935722240598 0.411086701629822 no 1337 0.409459437725645 423 788518
SGTC_2793 7325131 81.82 µM 0.228389267511732 0.411305132709007 no 1338 0.409671816139093 437 4176441
SGTC_1553 gossypol 38.6 µM 0.227957636380538 0.41147768547982 no 1339 0.409839587357793 470 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_801 0866-0028 10.1 µM 0.227880277807901 0.411508612854002 no 1340 0.409869657698913 455 6849771
SGTC_1643 st009866 20.2 µM 0.225435614958723 0.412486252904949 no 1341 0.410820203946348 449 3156273 YOR207C RET1
SGTC_3193 9111931 49.47 µM 0.224698640201968 0.412781081791152 no 1342 0.411106861261821 436 17087244
SGTC_839 0122-0028 230 µM 0.224176957032618 0.412989812410092 no 1343 0.411309806411042 464 759448
SGTC_2689 tacrolimus 100 µM 0.223259637794346 0.413356900577587 no 1344 0.411666719405902 466 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1336 1486-0901 104 µM 0.223171673755033 0.413392105566754 no 1345 0.411700948532577 413 5006114
SGTC_2051 5263410 176 µM 0.223022756890942 0.413451706697341 no 1346 0.411758897541843 447 227584
SGTC_547 1120-0019 610 nM 0.221664320859204 0.413995486680188 no 1347 0.412287603487722 446 3676939
SGTC_2777 climbazole 1.536 µM 0.221148370583623 0.414202064106626 no 1348 0.412488454111597 466 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1520 flindersine 88 µM 0.22063984016804 0.414405693981172 no 1349 0.412686438737687 451 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_843 0310-0051 143 µM 0.220591280551724 0.414425139820948 no 1350 0.412705345470639 465 2065037
SGTC_2233 sulbentine 40.3845 µM 0.220181936723014 0.414589071081298 no 1351 0.412864731926207 443 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_252 miconazole 1.30953 nM 0.220044286521619 0.414644199651047 no 1352 0.412918332097817 455 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_957 1187-1561 14.1 µM 0.219380554173921 0.41491004641596 no 1353 0.4131768083063 463 1538454
SGTC_265 mycophenolic acid 32.932 µM 0.218359351654823 0.415319147877769 no 1354 0.413574567010052 451 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3290 9121031 71.43 µM 0.21771143036601 0.415578757691361 no 1355 0.41382697857647 436 17014854
SGTC_3085 9117376 49.47 µM 0.21667414478284 0.415994455102202 no 1356 0.414231149406224 473 16480349
SGTC_2197 6588183 93.1375 µM 0.216498342490544 0.416064918083284 no 1357 0.414299658513509 427 884136
SGTC_2967 9089538 49.85 µM 0.215964804313718 0.416278781011743 no 1358 0.414507591123378 442 728216
SGTC_2575 plumbagin 510 nM 0.215516304932862 0.41645857625149 no 1359 0.414682400615826 454 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_135 0933-0004 26.348 µM 0.215061701278366 0.416640836422377 no 1360 0.414859606586378 480 21230617 YGL099W LSG1
SGTC_1857 st056007 79.3 µM 0.214585377724149 0.416831823783952 no 1361 0.415045297630641 428 619834
SGTC_3002 9075603 71.4286 µM 0.214434120984224 0.416892476007772 no 1362 0.415104267870472 464 20105405
SGTC_3094 9117742 49.47 µM 0.214228571589445 0.416974902136064 no 1363 0.415184408172267 475 17149698
SGTC_3350 9150499 3.57 µM 0.214131225997446 0.417013939380981 no 1364 0.415222362836568 465 4910996 YPR165W RHO1
SGTC_1458 k015-0034 6.33 µM 0.213834781606089 0.41713282368285 no 1365 0.415337950213127 451 3598957
SGTC_2987 9018338 71.43 µM 0.213746842434918 0.417168091744628 no 1366 0.415372240205691 462 5055682
SGTC_425 3825-7017 13.1 µM 0.213627166108829 0.417216089083691 no 1367 0.415418906456109 484 3397440
SGTC_1730 st033808 45.1 µM 0.213313361245419 0.417341949392454 no 1368 0.415541276307156 477 1045166
SGTC_1410 3909-8106 77.9 µM 0.211429237583052 0.41809780808743 no 1369 0.416276172042391 462 1039210
SGTC_2411 st077133 39.94 µM 0.211427962595076 0.418098319680376 no 1370 0.416276669446338 472 1403142 YNL221C POP1
SGTC_3312 9133330 71.43 µM 0.211412895459118 0.418104365426679 no 1371 0.416282547514201 454 17617324
SGTC_1225 1216-0074 20.6 µM 0.210881555450001 0.41831758001447 no 1372 0.416489848549775 444 4241466
SGTC_2993 9054257 71.4286 µM 0.210827444433198 0.418339294875165 no 1373 0.41651096113797 463 6470217 YGL055W OLE1
SGTC_2077 5212015 200 µM 0.209571523455374 0.418843368302656 no 1374 0.417001053526698 457 780900
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.209483779344878 0.418878590058279 no 1375 0.417035298345978 453 688751
SGTC_1481 3346-2004 36 µM 0.2090980577658 0.419033431989988 no 1376 0.417185845436345 471 2770522
SGTC_2106 5357045 167.29 µM 0.208803879050316 0.419151533894062 no 1377 0.417300671520067 441 668842
SGTC_2657 nystatin 74.44 µM 0.207540633043469 0.41965876325446 no 1378 0.417793831410212 434 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1838 st055369 84.5 µM 0.206157843666114 0.420214145731107 no 1379 0.418333808176297 410 676036
SGTC_2266 7929956 200 µM 0.2061282504736 0.420226033259123 no 1380 0.418345365950955 467 2967153
SGTC_1255 0566-0045 221 µM 0.205740004996525 0.42038199744995 no 1381 0.418497003759787 451 2788469
SGTC_1645 Cervolide 78 µM 0.205597250911681 0.420439347110239 no 1382 0.418552762553754 447 23173 A fragrance.
SGTC_1038 k292-0204 154 µM 0.205302999302623 0.420557564325038 no 1383 0.418667700432874 453 4454212
SGTC_3107 9121808 49.47 µM 0.205194484307779 0.420601162634721 no 1384 0.418710089323234 426 662681
SGTC_1525 8-methoxypsoralen 92.5 µM 0.20493792031875 0.420704246789314 no 1385 0.418810313905834 480 4114 Related to psoralen; DNA damaging agent.
SGTC_3255 9139072 49.47 µM 0.204894631273908 0.420721640314463 no 1386 0.418827224929949 445 17646060
SGTC_1477 0139-0234 16 µM 0.204384998820495 0.420926422108099 no 1387 0.419026325986123 447 620880
SGTC_2462 5162487 171.77 µM 0.204384850848326 0.420926481569758 no 1388 0.419026383798279 469 2259986
SGTC_607 4491-0986 66.8 µM 0.203445876024255 0.421303838795591 no 1389 0.419393272802424 440 698981 YDR232W HEM1
SGTC_2401 5128683 200 µM 0.20101502815632 0.422281088203303 no 1390 0.42034341157004 456 708373
SGTC_841 0251-0215 91.2 µM 0.200495072593516 0.422490183073075 no 1391 0.420546705632141 473 3888614
SGTC_3310 9130229 44.1445 µM 0.200467925804439 0.422501100480192 no 1392 0.420557320162216 462 7761258
SGTC_1717 st033143 58.0435 µM 0.199658179609658 0.422826776970427 no 1393 0.420873961493682 468 674616
SGTC_140 0062-0056 502.533 µM 0.199152884016714 0.423030031462532 no 1394 0.42107157710051 419 3758964
SGTC_2111 5486399 200 µM 0.198810370721893 0.423167818642724 no 1395 0.421205541634343 440 689674
SGTC_94 0334-0113 514.748 µM 0.198416592958793 0.423326240244922 no 1396 0.421359568108865 478 6795178
SGTC_2168 5727979 200 µM 0.198285341297788 0.423379047146641 no 1397 0.421410909972246 458 695210
SGTC_218 alverine citrate 93.75 µM 0.196342181109659 0.424161005543307 no 1398 0.422171174051099 463 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1448 4255-0083 152 µM 0.195959997004464 0.424314837715497 no 1399 0.42232073833295 465 5399660
SGTC_1993 st073995 70.8 µM 0.19593979048267 0.424322971323966 no 1400 0.422328646283877 439 3098394
SGTC_2149 5554786 194.827 µM 0.195713571628244 0.424414032024588 no 1401 0.42241718060918 432 745063 YPR165W RHO1
SGTC_2367 9070478 135.38 µM 0.195652068068567 0.424438789974595 no 1402 0.422441251677573 452 572802
SGTC_728 3030-5151 22.5 µM 0.194203240320419 0.425022094357169 no 1403 0.423008372882599 442 3125388
SGTC_350 k064-0020 19.8 µM 0.193996605885529 0.425105299691765 no 1404 0.423089269765415 442 2790705
SGTC_1381 2324-0066 62.1 µM 0.193714911942956 0.42521873455626 no 1405 0.423199557487641 458 10885928
SGTC_1019 4262-0212 3.4 µM 0.193569733401782 0.425277198679397 no 1406 0.423256399578913 468 4677213
SGTC_2066 5222451 176 µM 0.191532241424735 0.426097879651129 no 1407 0.424054311539527 474 2281147
SGTC_1635 st007035 42.4 µM 0.191312626990233 0.426186357281156 no 1408 0.424140334447199 434 3716403
SGTC_2882 9058044 58.44 µM 0.191043429603321 0.426294815816154 no 1409 0.424245783912418 440 18076804
SGTC_3196 9111891 49.47 µM 0.190389496734995 0.426558305918742 no 1410 0.424501963769195 475 18891510
SGTC_2351 9026858 72.31 µM 0.189859231164031 0.426771990654591 no 1411 0.424709720073096 458 1409300
SGTC_3353 9151644 39.2805 µM 0.189696304935436 0.426837650468177 no 1412 0.424773558236127 485 4909158
SGTC_377 3970-0964 33.1 µM 0.187751424279558 0.427621599902717 no 1413 0.425535758138985 450 16481235
SGTC_74 000s-0487 160.283 µM 0.186912543449722 0.42795982739909 no 1414 0.425864602134472 384 677548
SGTC_885 0865-0106 16.8 µM 0.186448429858712 0.428146975641222 no 1415 0.42604655833225 463 2793380
SGTC_1231 0242-0792 125 µM 0.18640336436521 0.42816514862284 no 1416 0.426064227143376 469 3707635
SGTC_1065 prochlorperazine maleate 2.48 µM 0.185677392627664 0.428457922872593 no 1417 0.426348879040304 488 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2752 diclazuril 33.15 µM 0.185539820954674 0.428513408047604 no 1418 0.426402824915244 444 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_228 caffeine 993.056 µM 0.185501981560834 0.428528669615907 no 1419 0.426417663089318 448 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_130 0136-0219 337.655 µM 0.18313416309491 0.429483881361563 no 1420 0.427346375383683 483 234244
SGTC_81 0411-0046 9.971 µM 0.181798167298224 0.430023023746672 no 1421 0.427870561419805 452 12925265
SGTC_3204 9114183 49.47 µM 0.181699095797564 0.430063009355737 no 1422 0.427909437805012 417 17027248
SGTC_3292 9120825 59.784 µM 0.181197952872451 0.430265283400278 no 1423 0.428106100688836 483 24824900
SGTC_20 0481-0013 4.944 µM 0.181189466239203 0.430268708979274 no 1424 0.428109431241493 471 182045
SGTC_853 0419-0306 21 µM 0.179675966164757 0.43087970796381 no 1425 0.428703481288224 474 762713
SGTC_1626 st003712 1.76 µM 0.178837279894678 0.431218356409409 no 1426 0.42903273600731 464 24207035
SGTC_1153 4055-0057 267 µM 0.178680478024279 0.431281676179662 no 1427 0.42909429938242 454 882706
SGTC_1675 st018485 24.5 µM 0.178349074253239 0.431415509541752 no 1428 0.429224420434074 486 3323024
SGTC_1002 4049-0206 172 µM 0.178218398847116 0.431468283372597 no 1429 0.429275730418079 457 4662749
SGTC_2864 9034755 47.6 µM 0.177872385114873 0.431608028428322 no 1430 0.429411599235711 466 4930451
SGTC_870 0573-2213 57.6 µM 0.177681158649337 0.431685263005281 no 1431 0.429486691502713 466 3916321
SGTC_3151 9099821 49.47 µM 0.17724154247999 0.43186282975366 no 1432 0.429659333003966 446 17174189
SGTC_1757 st041620 31.8375 µM 0.177040846851086 0.431943897935078 no 1433 0.429738152583722 455 5289815
SGTC_2458 5808907 16.39 µM 0.176488454006836 0.432167044058312 no 1434 0.42995510933942 477 2731747
SGTC_1093 fluphenazine 7.97 µM 0.17629554453767 0.432244977396911 no 1435 0.430030881079712 482 6602611 An atypical antipsychotic.
SGTC_2981 9013952 38.96 µM 0.175000119745103 0.432768383146799 no 1436 0.43053976974687 417 2996344
SGTC_1070 indatraline 8.81 µM 0.17458811256075 0.432934876039066 no 1437 0.430701644961016 477 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2977 9011197 71.43 µM 0.174245523197221 0.433073326123994 no 1438 0.430836255187067 509 2704722
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.173829962927384 0.433241276847743 no 1439 0.430999547928441 455 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.172438356877717 0.433803788893784 no 1440 0.431546459681476 455 688801
SGTC_1453 4237-0541 195 µM 0.171560344668871 0.434158766191761 no 1441 0.431891592749168 447 739892
SGTC_1731 st035964 63 µM 0.170487998360921 0.434592384096116 no 1442 0.432313186057315 462 6739575
SGTC_646 4092-0839 27.3 µM 0.169351484595022 0.435052034879205 no 1443 0.432760090953165 476 877796
SGTC_2083 5306046 65.942 µM 0.168639712171561 0.435339948332843 no 1444 0.433040021050745 434 539837
SGTC_3033 9090887 49.47 µM 0.168532815848287 0.435383191086679 no 1445 0.433082064778996 446 19325384
SGTC_2418 pentamidine 31.67 µM 0.167378988436237 0.435849997797456 no 1446 0.433535928373361 477 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1613 st002381 52.1 µM 0.166764173178274 0.436098771620086 no 1447 0.43377780476663 442 551167
SGTC_1234 0326-0494 15.5 µM 0.166692911933 0.436127607825055 no 1448 0.433805841481546 485 1547813
SGTC_1061 3448-9325 110 µM 0.166287249613468 0.436291767492887 no 1449 0.433965449843186 485 723482
SGTC_1385 3091-4834 14.1 µM 0.16461626349538 0.436968082070418 no 1450 0.434623014721074 455 4072814
SGTC_1296 1068-0102 11.9 µM 0.164184137662544 0.437143010656633 no 1451 0.434793093982452 481 767053
SGTC_1262 0737-0114 49.6 µM 0.16369702343403 0.437340213793594 no 1452 0.434984830447489 489 765919
SGTC_1816 st051957 91.6 µM 0.163313535515436 0.437495475849902 no 1453 0.435135788589011 487 674121
SGTC_209 4077-0173 175.592 µM 0.163166393234254 0.437555051634119 no 1454 0.435193712938544 479 15993494
SGTC_2880 9042983 58.44 µM 0.161961135764118 0.438043096145555 no 1455 0.435668229447786 464 6464714
SGTC_1276 0871-0068 94.2 µM 0.161934110036486 0.438054040747753 no 1456 0.435678870690123 467 3414906
SGTC_268 camptothecin 39.6153 µM 0.161655897384668 0.438166711209292 no 1457 0.435788418207953 471 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3065 9113888 49.47 µM 0.160961869344936 0.438447800268651 no 1458 0.436061716414879 460 16648368
SGTC_1085 doxorubicin 7.67 µM 0.159770049957541 0.438930572720909 no 1459 0.436531108820382 482 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1831 st055328 12 µM 0.159587323623541 0.439004598061516 no 1460 0.436603082638444 472 1103068
SGTC_501 nsc-95397 161 µM 0.159272312547591 0.439132219060194 no 1461 0.43672716683371 477 262093
SGTC_581 0958-0271 211 µM 0.159124969092742 0.439191914749416 no 1462 0.436785208181612 449 4591145
SGTC_715 0868-0130 184 µM 0.158639933654954 0.439388434935513 no 1463 0.436976282336165 456 2876258
SGTC_2249 haloperidol 116.36 µM 0.157692742882566 0.439772248080398 no 1464 0.437349459641887 490 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2301 7769476 200 µM 0.157622167031349 0.439800848538741 no 1465 0.43737726758116 446 977820
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.156716099278018 0.440168055147309 no 1466 0.437734299237617 421 6708561
SGTC_2396 5342950 42.78 µM 0.156446637907114 0.44027727104803 no 1467 0.437840488993683 471 1886677
SGTC_1878 temozolomide 1 mM 0.155020603460691 0.440855335243492 no 1468 0.438402537221297 487 5394 DNA alkylating agent.
SGTC_2910 7948405 25.97 µM 0.15431448407868 0.441141617936041 no 1469 0.43868088873187 489 2971328
SGTC_1868 st057644 42.7 µM 0.153342406707334 0.441535778532505 no 1470 0.439064130191906 450 688665
SGTC_3137 9097352 49.47 µM 0.153217908384313 0.441586264645011 no 1471 0.439113217784633 489 44120435
SGTC_1941 st076221 61.8 µM 0.152036450113775 0.44206541248035 no 1472 0.439579093390838 452 2828568
SGTC_2388 9080168 200 µM 0.151871088425388 0.442132482732634 no 1473 0.43964430592012 500 15943073
SGTC_3138 9097216 49.47 µM 0.151584660458789 0.442248661063161 no 1474 0.439757266382673 496 25237486
SGTC_17 0960-0276 49.807 µM 0.151172550422257 0.442415826134595 no 1475 0.439919801504289 474 6821114
SGTC_2076 5212012 200 µM 0.150954786309026 0.442504162397831 no 1476 0.440005691192397 472 604802
SGTC_1925 st057770 10.1 µM 0.149924646750711 0.442922078369491 no 1477 0.440412033097083 427 5989122
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.148351737790705 0.443560312119234 no 1478 0.441032593093573 487 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_473 2-arachidonoylglycerol 10 µM 0.147140559977813 0.444051867371079 no 1479 0.441510538019907 490 5282280 An endocannabinoid.
SGTC_3041 9091929 49.47 µM 0.147086244773325 0.444073913162473 no 1480 0.441531973435467 457 25236887
SGTC_1854 st056233 32.9 µM 0.145101823622277 0.444879480413427 no 1481 0.44231523924318 483 5393174
SGTC_1447 4239-0816 81.9 µM 0.144223444672082 0.445236127477537 no 1482 0.442662014155958 458 1341554
SGTC_1014 4130-3005 69.3 µM 0.144136312252594 0.445271508162082 no 1483 0.442696415532261 455 743608
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.143505656261657 0.445527603099866 no 1484 0.442945422217864 469 23665772 A membrane-active detergent.
SGTC_665 3914-0008 307 µM 0.143475450769675 0.445539869428865 no 1485 0.442957349047563 469 1069549
SGTC_2340 7987427 183.45 µM 0.143131525989054 0.445679539574579 no 1486 0.443093153566306 473 2239331
SGTC_387 norethindrone acetate 66.7 µM 0.143120317174957 0.445684091662225 no 1487 0.443097579668779 469 541197
SGTC_3014 9081533 49.47 µM 0.142146628502666 0.446079550246279 no 1488 0.443482093933842 492 21367265
SGTC_1915 st067105 30.6 µM 0.140915602361382 0.446579601837106 no 1489 0.443968308119657 493 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1028 k015-0029 4.8 µM 0.140285451552234 0.446835606511697 no 1490 0.44421722931625 504 4588309
SGTC_767 0929-0023 86 µM 0.140268542672168 0.446842476208478 no 1491 0.444223908939461 483 1204563
SGTC_3187 9109394 49.47 µM 0.140252208143028 0.446849112574573 no 1492 0.444230361688191 479 17098090
SGTC_578 3460-0051 92 µM 0.140045699784066 0.446933013739776 no 1493 0.444311941472603 494 2876744
SGTC_2343 7990716 14.84 µM 0.139872939186611 0.447003205534182 no 1494 0.444380191235935 485 6456862
SGTC_2786 7743617 45.45 µM 0.139027735305082 0.447346631667996 no 1495 0.44471411613597 469 583674
SGTC_2867 9039098 71.43 µM 0.138739706669904 0.44746367348136 no 1496 0.444827920062209 474 6463460
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.138476610438027 0.447570587891735 no 1497 0.444931876840467 488 6710655
SGTC_527 4476-4215 268 µM 0.138130382729233 0.447711290242715 no 1498 0.445068686992036 490 4418754
SGTC_1444 4112-3581 28 µM 0.13654418104639 0.448355985435574 no 1499 0.445695550081085 484 2877249
SGTC_563 tetrahydrosecaminediol 614 µM 0.132258377172259 0.45009858337062 no 1500 0.447389964151197 470 334274 A psychoactive constituent of the cannabis plant.
SGTC_833 3852-0053 558 µM 0.13118509211504 0.450535130619592 no 1501 0.447814444402772 467 3123681
SGTC_1995 st072814 61.1 µM 0.130374931898837 0.450864694314532 no 1502 0.448134899370453 466 5769371
SGTC_217 ketoconazole 989 nM 0.129562479278058 0.451195224553942 no 1503 0.44845629508103 481 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2706 st078239 82.5 µM 0.129146133512832 0.451364619702586 no 1504 0.448621009185827 499 15434492
SGTC_1105 epirubicin 18.1 µM 0.128894566022384 0.451466977175631 no 1505 0.448720538244063 492 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1758 st042942 75.2445 µM 0.128635482609805 0.451572396090688 no 1506 0.448823044242114 496 669317
SGTC_2614 arthonioic acid 13.39 µM 0.128107250195493 0.4517873400983 no 1507 0.449032049250863 470 6710684
SGTC_3194 9111903 49.47 µM 0.127571719593785 0.45200526825264 no 1508 0.449243956361736 500 17087251
SGTC_2438 5259590 200 µM 0.127531510407564 0.452021631513183 no 1509 0.449259867545477 498 1201127
SGTC_2878 9043973 25.97 µM 0.126736995006393 0.452344978849062 no 1510 0.449574282068509 468 6465167
SGTC_1390 3413-2614 145 µM 0.125412822393093 0.452883953186248 no 1511 0.450098368729479 497 3421432
SGTC_1275 0867-0008 21.1 µM 0.124695831041822 0.453175824498218 no 1512 0.450382178993806 488 3422836
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.12364394876765 0.453604068230409 no 1513 0.450798596684619 475 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2954 9074818 52.69 µM 0.122845916873797 0.453929000073948 no 1514 0.451114556597578 498 16648742
SGTC_2854 9024559 71.43 µM 0.122795482688538 0.453949536222393 no 1515 0.451134525740508 476 3163529
SGTC_993 3909-8757 62.7 µM 0.122256585061396 0.454168976046942 no 1516 0.451347907052458 477 4288324 YLR208W SEC13
SGTC_61 0978-8327 98.565 µM 0.121176294816393 0.454608913726361 no 1517 0.451775699867939 474 6150059 YHR072W ERG7
SGTC_195 4234-0266 16.654 µM 0.121009349508303 0.454676905558146 no 1518 0.451841814890561 505 2303354
SGTC_1169 aniline yellow 25.8 µM 0.120573916875327 0.454854250492379 no 1519 0.452014264701851 504 6051 A DNA damaging agent.
SGTC_291 SEC14.278 35.5 µM 0.120185393224101 0.455012497726279 no 1520 0.452168144209176 490 1068044
SGTC_2749 bexarotene 57.39 µM 0.119152020804429 0.455433429117592 no 1521 0.452577458807652 488 82146 An retinoic acid receptor inhibitor.
SGTC_1467 k284-1082 293 µM 0.116958201274084 0.45632721948399 no 1522 0.453446588316225 483 3334705
SGTC_2938 9059746 27.26 µM 0.114868209674965 0.457178914665181 no 1523 0.45427479163393 482 6471769
SGTC_1619 st003326 88.7 µM 0.112008136178767 0.458344744947472 no 1524 0.455408477715853 490 2849032
SGTC_2140 5586273 200 µM 0.111079942729092 0.458723174995377 no 1525 0.455776476842432 506 854421
SGTC_517 1365-0151 113 µM 0.110234969934541 0.45906770802174 no 1526 0.456111514632665 481 768657
SGTC_2937 9044753 11.33 µM 0.108408161666413 0.459812683836753 no 1527 0.456835963609803 493 6465530 YGL099W LSG1
SGTC_413 propylparaben 100 µM 0.107604826619097 0.460140330192064 no 1528 0.457154584068644 480 7175 A pharmaceutical preservative.
SGTC_731 3966-0296 387 µM 0.106345518216547 0.46065400316484 no 1529 0.457654109005313 490 660956
SGTC_1425 4048-4433 7.33 µM 0.105920440634918 0.460827407539311 no 1530 0.457822738008086 515 23734946
SGTC_642 0335-0876 158 µM 0.105262907111666 0.46109565368183 no 1531 0.458083597625126 511 6812350
SGTC_3326 9140064 16.379 µM 0.104834962399821 0.461270246721125 no 1532 0.458253383456812 483 1868434
SGTC_1286 0929-0070 131 µM 0.104206469677929 0.461526672933414 no 1533 0.458502749933487 479 1420408
SGTC_3174 9107204 49.47 µM 0.104030998540101 0.461598268348433 no 1534 0.458572374375407 470 3938802
SGTC_9 0092-0002 10.449 µM 0.104001809823829 0.461610177996232 no 1535 0.458583956164585 495 759368
SGTC_98 0074-0023 107.663 µM 0.102690250391418 0.462145358888354 no 1536 0.459104405897906 511 3563821
SGTC_2069 5228469 200 µM 0.102552574649903 0.462201541368488 no 1537 0.459159042122124 504 2835210
SGTC_1310 1188-0297 994 nM 0.102159015161707 0.462362148603974 no 1538 0.459315229330208 495 1588352
SGTC_455 paf C-16 10 µM 0.102083338305825 0.462393032188662 no 1539 0.459345263011997 490 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1319 1306-0155 43.7 µM 0.1014688560492 0.462643809637338 no 1540 0.459589139601921 498 3122360
SGTC_1873 rapamycin 2 nM 0.101253847531718 0.462731560658382 no 1541 0.459674476083327 490 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_58 0957-0393 9 µM 0.101209339741003 0.462749725765853 no 1542 0.459692141375053 487 6997992
SGTC_2459 5811157 9.22 µM 0.100911638212178 0.462871229641948 no 1543 0.45981030215694 495 2870684 YBR192W RIM2
SGTC_313 3474-0040 5.03 µM 0.100236301166785 0.463146874469976 no 1544 0.460078363481965 503 1043375 YIL048W NEO1
SGTC_1374 2889-5571 141 µM 0.0990894103251713 0.463615028651003 no 1545 0.460533640021772 496 2853281
SGTC_48 0382-0018 55 µM 0.0978918445275809 0.464103921823126 no 1546 0.461009088003662 495 762596
SGTC_492 tmb-8 126 µM 0.0969076091193406 0.464505765806225 no 1547 0.461399883024007 510 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1728 st035614 33.7865 µM 0.0966204702282672 0.46462300581534 no 1548 0.461513899830559 479 15945546
SGTC_2838 9002687 71.43 µM 0.0961130413934957 0.46483019863265 no 1549 0.46171539686309 491 6457060
SGTC_899 1083-0020 478 µM 0.0956510616986762 0.465018841998807 no 1550 0.461898854854857 510 767123
SGTC_625 k213-0058 121 µM 0.0954749136780875 0.465090771811879 no 1551 0.461968807603229 509 3655420
SGTC_1660 st012960 28.1 µM 0.0953176844442197 0.465154977126787 no 1552 0.462031248225882 512 24207266
SGTC_2037 5169046 200 µM 0.0950534863583776 0.4652628657296 no 1553 0.462136171615696 483 5718022
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.0948735407522739 0.465336350237693 no 1554 0.462207636560564 500 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.0947244887736862 0.465397219589543 no 1555 0.462266833102916 501 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_594 1487-1584 10.8 µM 0.0943155922800882 0.465564207533971 no 1556 0.462429232139117 493 5013332
SGTC_2767 sibutramine 71.45 µM 0.0938456023215821 0.465756152733669 no 1557 0.462615903045557 505 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_376 3970-0862 59.1 µM 0.0931238324405799 0.466050941046528 no 1558 0.4629025920766 505 3135186
SGTC_2147 5545932 89.7195 µM 0.0916193938497366 0.466665449921249 no 1559 0.463500221096921 506 797404
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.0910313729711673 0.466905656912623 no 1560 0.463733831257286 481 94937 An inhibitor of serotonin biosynthesis.
SGTC_2684 capsaicin 100 µM 0.0899953294492197 0.467328910780828 no 1561 0.464145463164373 504 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2337 9009472 200 µM 0.0895146499506428 0.467525294891129 no 1562 0.464336455672545 504 5742383
SGTC_1293 1000-1278 195 µM 0.0894475712893817 0.467552700856815 no 1563 0.464363109266828 509 678847
SGTC_855 0428-0020 25 µM 0.0893691115651173 0.467584756916985 no 1564 0.464394285310449 510 6812414
SGTC_2769 toremifene 3.73 µM 0.0893332895747897 0.467599392672761 no 1565 0.464408519283961 505 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2972 9093619 59.92 µM 0.0882422233565204 0.468045189428227 no 1566 0.464842079400503 438 25236256
SGTC_2519 cryptotanshinone 88.04 µM 0.0873652575600113 0.468403536361187 no 1567 0.465190592102664 509 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2950 9072895 21.46 µM 0.0872171298015838 0.468464067058673 no 1568 0.465249461814238 490 17332245
SGTC_2760 etidronate 98.04 µM 0.0867893458799507 0.468638880104986 no 1569 0.465419478211967 516 3305 A chelator and antioxidant.
SGTC_1901 st060216 58.6 µM 0.0863936214276635 0.46880059749789 no 1570 0.465576758668536 481 688792
SGTC_1351 1496-0003 46.5 µM 0.0854313598306532 0.469193858299488 no 1571 0.465959231374796 506 3891978
SGTC_1632 st005650 90 µM 0.0851224466456635 0.469320112529727 no 1572 0.466082022613908 500 2759605
SGTC_1208 2323-2347 50.3 µM 0.0850283125397749 0.469358586182788 no 1573 0.466119441029558 519 5412760
SGTC_1943 st076331 65.2 µM 0.0838385999529915 0.469844859449934 no 1574 0.466592378857181 522 24208415
SGTC_812 4251-0442 148 µM 0.0819960333048386 0.470598063389352 no 1575 0.467324933899886 519 5723007
SGTC_2923 7992654 58.14 µM 0.0816493503515435 0.470739792201566 no 1576 0.467462778183493 522 2985126
SGTC_304 1310-0298 97 µM 0.080994055245715 0.471007696062577 no 1577 0.467723340100127 523 1550234
SGTC_1168 k815-0004 80.5 µM 0.0785841839515325 0.471993034062869 no 1578 0.468681684004076 504 642433
SGTC_2485 5633444 17.78 µM 0.078120877168263 0.472182488818612 no 1579 0.468865950182089 513 5724239
SGTC_2572 astragaloside iv 100 µM 0.0772449910314585 0.472540672103659 no 1580 0.469214325437018 510 45006101 An anti-inflammatory agent.
SGTC_2703 st077852 53.4 µM 0.0763235768216834 0.472917497518704 no 1581 0.469580834479233 491 6281836
SGTC_626 0214-0009 33 µM 0.0759879768946678 0.473054751910318 no 1582 0.469714331794606 500 3437874
SGTC_138 0850-0259 40.9225 µM 0.0752715737679154 0.473347758710307 no 1583 0.469999319074918 512 6813004
SGTC_206 4546-0025 72.014 µM 0.0751164974038588 0.473411186397281 no 1584 0.470061010939095 518 6620745 YIL048W NEO1
SGTC_1480 1070-0044 41.2 µM 0.0747328441722744 0.473568107059735 no 1585 0.470213637431312 509 3124987
SGTC_2424 5537928 59.2 µM 0.0746855953251196 0.473587432921749 no 1586 0.470232434463363 518 5382802
SGTC_699 0375-0592 111 µM 0.0746777658013589 0.473590635382523 no 1587 0.470235549293051 520 762578
SGTC_2057 5236571 38.335 µM 0.0740849394389213 0.473833120356566 no 1588 0.470471399456669 506 54684039 YBR257W POP4
SGTC_2433 5607874 27.82 µM 0.0739771768656524 0.473877199745331 no 1589 0.470514272856324 525 2252428
SGTC_1380 2291-0730 164 µM 0.0735682389870733 0.474044475305372 no 1590 0.47067697212382 497 2999191
SGTC_2210 7115885 190.385 µM 0.0727098898870636 0.474395596847482 no 1591 0.471018489195518 527 2927039
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.0711035975537301 0.475052729856928 no 1592 0.471657652493181 503 77254
SGTC_356 1634-0012 32.5 µM 0.0709266859390116 0.475125108449648 no 1593 0.471728052273754 515 735457
SGTC_2016 5121758 140 µM 0.0706852988383879 0.475223866763816 no 1594 0.471824110697942 520 2795203
SGTC_2930 9013230 14.89 µM 0.0706550456867668 0.475236244294293 no 1595 0.471836149858242 500 2995857
SGTC_2405 ticlatone 3.52 µM 0.0705790123329147 0.475267352072999 no 1596 0.471866407240451 431 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.0703892035911796 0.475345009811762 no 1597 0.471941942110402 498 2724 A muscle relaxant with antifungal properties.
SGTC_1162 k048-0130 20.1 µM 0.0700807408589626 0.475471215259558 no 1598 0.472064697788135 502 6797406
SGTC_1888 azatryptophan 97.5 µM 0.069645854724776 0.475649150167927 no 1599 0.472237769366223 469 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1565 sinapyl alcohol 95.1 µM 0.0692192513974211 0.475823700860827 no 1600 0.472407549730221 520 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2256 7954252 200 µM 0.0681968987014687 0.476242029524671 no 1601 0.472814447851794 511 2972920
SGTC_775 4577-0580 57.3 µM 0.0673126787209567 0.476603857856551 no 1602 0.473166391811339 510 2006902
SGTC_2390 9097792 176.6 µM 0.0663839393354437 0.476983924573403 no 1603 0.473536078274667 507 4497149
SGTC_3313 9133968 57.047 µM 0.0655276205165791 0.477334373283181 no 1604 0.473876957798619 521 1494643
SGTC_1274 0865-0114 173 µM 0.0646745620382671 0.477683505126925 no 1605 0.474216558480305 509 870624
SGTC_85 0868-0259 160.055 µM 0.0626633486085776 0.478506703178637 no 1606 0.475017291791069 517 83173
SGTC_375 3970-0961 9.27 µM 0.0608456984222768 0.479250753972403 no 1607 0.475741047819665 519 2898222
SGTC_2881 9058953 51.95 µM 0.0601901094498474 0.479519135643481 no 1608 0.476002111474738 519 17122249
SGTC_1722 st034304 3.6505 µM 0.0595427640073966 0.479784151732034 no 1609 0.476259902562728 513 4036148 YLR033W RSC58
SGTC_3322 9139058 2.11 µM 0.0585549508193198 0.480188568746159 no 1610 0.476653296557728 484 4908926 YPR165W RHO1
SGTC_2557 derrustone 83.84 µM 0.0585507587061658 0.48019028506775 no 1611 0.476654966104487 521 629853 An antioxidant.
SGTC_63 0099-0242 26.702 µM 0.0575313010587012 0.480607678992812 no 1612 0.477060986376636 520 3898502 YLR359W ADE13
SGTC_2013 4024628 200 µM 0.0561567023869413 0.481170510973721 no 1613 0.477608486594966 519 5230760
SGTC_811 0416-0114 265 µM 0.0541430307208012 0.48199508003609 no 1614 0.47841060447424 525 6612453
SGTC_3126 9127922 49.47 µM 0.052625798414505 0.482616415525546 no 1615 0.479015030642818 533 45595682
SGTC_1636 st007707 68.9 µM 0.0522739684070043 0.482760502691856 no 1616 0.479155197576009 526 403051
SGTC_1017 4239-0030 168 µM 0.0474428795005129 0.484739228725581 no 1617 0.481080127288828 526 1149593
SGTC_1482 3346-2049 8.48 µM 0.0433199234925469 0.486428215566533 no 1618 0.482723254739433 521 3826804
SGTC_231 b-estradiol 524 µM 0.0431848676741403 0.486483546052948 no 1619 0.482777083841086 531 450 A steroid.
SGTC_1167 k781-0610 148 µM 0.0426622634835111 0.486697652147738 no 1620 0.482985380771348 524 4525169
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.0417440502953996 0.487073844832592 no 1621 0.483351368744719 526 689007
SGTC_1779 st039427 55 µM 0.0409114782038169 0.487414960243184 no 1622 0.483683233413119 526 1124498
SGTC_2006 4011487 200 µM 0.0404660129816304 0.487597476826409 no 1623 0.483860801274008 525 45595294
SGTC_638 3970-0837 4.09 µM 0.0399048843894677 0.487827386846411 no 1624 0.484084478513435 532 4118451 YLR208W SEC13
SGTC_2058 5236698 133 µM 0.0392915178106332 0.488078704850235 no 1625 0.484328984601207 519 766665
SGTC_2093 5331342 194.4 µM 0.0389001663881206 0.488239057864035 no 1626 0.484484991956136 528 33839
SGTC_406 estrone 100 µM 0.0387663010140472 0.488293908533367 no 1627 0.484538356261301 535 5870 A steroid.
SGTC_1557 sumaresinolic acid 42.3 µM 0.0370487974109038 0.488997666349453 no 1628 0.485223048858903 524 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_533 1222-0222 6.71 µM 0.0365795816252101 0.489189936495038 no 1629 0.485410112067836 520 3982874
SGTC_774 k060-0086 136 µM 0.0350909569948701 0.489799945332649 no 1630 0.486003606122795 539 5911235
SGTC_1497 4476-2978 41.3 µM 0.0346781388996199 0.489969114283922 no 1631 0.486168196535818 532 1528379
SGTC_305 1682-2595 20.8 µM 0.0340870625067997 0.490211334933535 no 1632 0.486403862557404 534 226033
SGTC_1059 3448-6867 171 µM 0.0339527359135877 0.490266381919879 no 1633 0.486457420113296 529 3934407
SGTC_42 0133-0086 60.653 µM 0.0339128589311321 0.490282723527719 no 1634 0.486473319571381 537 162923 Model of phenazepam hydroxylation.
SGTC_192 3455-0609 60.9 µM 0.033255089216588 0.49055228022684 no 1635 0.486735583773135 525 3769639
SGTC_1290 0986-0249 10.2 µM 0.0332314461476765 0.490561969333528 no 1636 0.486745010782558 537 53329
SGTC_2943 9068529 45.32 µM 0.0332301288307821 0.49056250918002 no 1637 0.486745536025875 536 3270634
SGTC_548 1436-0017 110 µM 0.0324393725186103 0.490886570220799 no 1638 0.487060832134611 535 9677137
SGTC_2806 7952793 58.44 µM 0.0324287321271302 0.490890930817228 no 1639 0.48706507480449 533 2972490
SGTC_2685 mycophenolic acid 18.85 µM 0.0319274920070957 0.491096347968535 no 1640 0.487264937180285 535 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2162 5663267 200 µM 0.0318734238053168 0.49111850622513 no 1641 0.487286496299504 528 6456493
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.0309410969159602 0.491500597134571 no 1642 0.487658257500543 536 97141
SGTC_1798 st045719 60.953 µM 0.0304941412905082 0.491683773531105 no 1643 0.487836482891423 538 3980186
SGTC_1867 st057372 64 µM 0.0298454788638453 0.491949618793602 no 1644 0.488095144008872 522 688837
SGTC_2931 9014674 55.67 µM 0.0295651753047136 0.492064498417275 no 1645 0.488206919622948 533 2996810
SGTC_1211 1056-0033 32.3 µM 0.0294988841216405 0.492091667295413 no 1646 0.488233354448731 535 6741922
SGTC_127 0180-0333 59.125 µM 0.0291993367578323 0.492214434692955 no 1647 0.488352805099989 530 771601
SGTC_920 mycophenolic acid 780.421 nM 0.0288549983263829 0.492355560307546 no 1648 0.48849011839772 533 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_142 0335-0849 62.6745 µM 0.027745270590918 0.492810383834958 no 1649 0.488932658438315 535 3889043 YPR107C YTH1
SGTC_1395 3486-0190 4.35 µM 0.0270709119406127 0.493086775312788 no 1650 0.489201587581758 534 6748079
SGTC_887 0885-0007 9.62 µM 0.0265250771285781 0.49331049266766 no 1651 0.489419265988687 533 5719458
SGTC_1815 st051655 58.2 µM 0.0260799744991921 0.493492925214199 no 1652 0.489596774832243 534 5984156
SGTC_1177 0983-0204 23.6 µM 0.0257042913295345 0.493646906127631 no 1653 0.489746600501601 533 766818
SGTC_2855 9016525 58.44 µM 0.0255515197035401 0.493709522764779 no 1654 0.489807527550986 529 43811474
SGTC_1801 st050089 28.441 µM 0.0236049990489219 0.494507357892064 no 1655 0.490583842299539 528 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1339 1486-1321 22.7 µM 0.0235613568149215 0.494525246127989 no 1656 0.490601248190933 529 3469382
SGTC_1665 st014639 11.4 µM 0.0232599049109179 0.494648806617932 no 1657 0.490721477149778 536 981133 YIL048W NEO1
SGTC_1313 1220-0047 237 µM 0.0231446006688921 0.494696068186232 no 1658 0.49076746450682 535 3528706
SGTC_2229 7354935 190 µM 0.0230586873141192 0.494731282896448 no 1659 0.490801729831798 537 318112
SGTC_322 k048-0136 19.3 µM 0.0229200332257206 0.494788115399216 no 1660 0.490857030194619 533 6823282
SGTC_1196 1588-0294 184 µM 0.0220391552453095 0.495149178219373 no 1661 0.491208360872963 535 6144269
SGTC_2932 9016711 44.54 µM 0.0216835618815508 0.495294933422727 no 1662 0.491350188204612 536 7117328
SGTC_158 k038-0087 26.446 µM 0.0215095629876532 0.495366254568062 no 1663 0.491419587533833 527 X158
SGTC_3266 9136860 49.47 µM 0.0214593374871657 0.495386841739338 no 1664 0.49143961998569 535 4871271 YPR165W RHO1
SGTC_2254 7938975 95.19 µM 0.0211913969306649 0.495496669385341 no 1665 0.491546488498865 526 2969277
SGTC_802 4112-3352 742 µM 0.0205410259891163 0.495763254953698 no 1666 0.491805892482586 528 704594
SGTC_1036 k216-0215 33.5 µM 0.0195508343539739 0.496169135844068 no 1667 0.492200842414234 539 622330
SGTC_263 alizarin 107.927 µM 0.0194370594427095 0.496215772596005 no 1668 0.492246223413236 537 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2643 anethole 100 µM 0.0178991910761055 0.496846155273023 no 1669 0.492859637169606 539 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_3042 9091578 49.47 µM 0.0174237402824207 0.497041047446048 no 1670 0.493049285011189 541 25236497
SGTC_1616 st002734 56.1 µM 0.0168948776528004 0.497257834507869 no 1671 0.493260239612989 542 4026101
SGTC_1750 st081859 2.357 µM 0.0167480799332679 0.497318008779779 no 1672 0.493318795144839 538 5291695
SGTC_234 nsc-17383 10.7 µM 0.0146905395949337 0.498161426804716 no 1673 0.494139533427551 540 408974
SGTC_3201 9113999 49.47 µM 0.0123423604621623 0.499123992049755 no 1674 0.495076235581347 536 16649224
SGTC_117 lucigenin 22.078 µM 0.0123127870952615 0.499136114804248 no 1675 0.495088032751341 538 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1840 st055363 71 µM 0.0122441453873217 0.499164252508909 no 1676 0.495115414766687 538 676033
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.0116203332764137 0.499419966612793 no 1677 0.495364262072857 544 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1272 0839-0021 27 µM 0.0105839039180265 0.499844821944574 no 1678 0.495777712064968 539 5027250
SGTC_1652 st011932 78 µM 0.00982679433946084 0.499844821944574 no 1679 0.496079739351189 542 1551076
SGTC_653 0203-0016 55.2 µM 0.0087993947294688 0.499423668104361 no 1680 0.49648959470193 546 295302
SGTC_2450 5739737 12.93 µM 0.00805670495241811 0.499119223499304 no 1681 0.496785874525544 544 2262825
SGTC_727 3032-0951 202 µM 0.00790218385914043 0.499055882019237 no 1682 0.496847517560321 542 3652836
SGTC_227 fluconazole 33.516 µM 0.00786581928635876 0.499040975411422 no 1683 0.496862024475048 541 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2378 9074213 121.43 µM 0.00772694248987102 0.498984046886574 no 1684 0.496917426617094 542 657714
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.00746142116358156 0.49887520415928 no 1685 0.497023351245722 543 88881 An O-methylated flavonoid and antioxidant.
SGTC_1745 st081495 74 µM 0.00618685559850131 0.498352734470156 no 1686 0.497531817464875 541 13842402 YBL026W LSM2
SGTC_644 1498-1197 63.3 µM 0.00592946488921727 0.498247225230469 no 1687 0.497634499616806 542 6741615
SGTC_1946 st076057 65.1 µM 0.00447219051104688 0.497649863883121 no 1688 0.498215860066413 546 953009
SGTC_255 tunicamycin 200.472 nM 0.0043238586268791 0.497589060414884 no 1689 0.49827503535418 542 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2344 7990960 76.95 µM 0.00347054495661117 0.497239275450356 no 1690 0.498615455660174 544 140813
SGTC_287 k060-0039 29.6 µM 0.00299340877221377 0.497043691699142 no 1691 0.49880580446167 546 5861974
SGTC_2974 9094440 9.66 µM 0.00066764004206663 0.496090342700027 no 1692 0.499733650178918 547 25236134
SGTC_2858 9025781 8.96 µM -0.00275400450550681 0.494687828618488 no 1693 0.498901312551177 550 4894980 YPL153C RAD53
SGTC_2896 9052656 71.43 µM -0.00287995778863127 0.494636202177788 no 1694 0.498851064660585 549 6469436
SGTC_1649 st011737 51.3 µM -0.00376747981213789 0.494272422250957 no 1695 0.498496996567961 554 1761035
SGTC_3320 9137005 35.139 µM -0.00455275449195956 0.493950555703684 no 1696 0.498183720015385 548 4908713
SGTC_2289 7946404 165.07 µM -0.00536603743360911 0.493617213349752 no 1697 0.497859271063007 555 1246120 YPR165W RHO1
SGTC_1214 0358-0031 63.7 µM -0.00569217421204665 0.49348354007538 no 1698 0.497729163302249 558 4301366
SGTC_1983 st071813 46.9 µM -0.00645552451958152 0.493170669524379 no 1699 0.497424636214514 556 11838595
SGTC_1678 st019265 80.2 µM -0.00685102013867694 0.493008571364289 no 1700 0.497266859783479 550 5367020
SGTC_3059 1327-0034 3 µM -0.00747394991756852 0.492753259203823 no 1701 0.497018353135401 552 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_308 4092-1169 104 µM -0.0080460439325673 0.492518785052109 no 1702 0.496790127519263 555 2268590 YDL196W YDL196W
SGTC_2970 9090938 41.86 µM -0.00818183776954332 0.492463129987618 no 1703 0.496735955399585 560 17217104
SGTC_1408 3909-7976 48.8 µM -0.00963856162952902 0.491866101588247 no 1704 0.496154829781069 553 24152374
SGTC_2171 5739187 198.077 µM -0.010005789744481 0.491715598457725 no 1705 0.496008334027055 551 2262761
SGTC_389 tpck 16.7 µM -0.0103863804854465 0.491559620093045 no 1706 0.495856508181995 558 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.0105861867362521 0.491477733560223 no 1707 0.495776801403277 553 551469
SGTC_219 mitoxanthrone 164.414 µM -0.0111773372578916 0.49123546464462 no 1708 0.495540980432065 555 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1575 cyproterone acetate 48 µM -0.0116571103346083 0.491038843486176 no 1709 0.49534959114309 556 9880 An androgen receptor antagonist and liver toxin.
SGTC_1663 st014140 55.4 µM -0.0122261447723479 0.490805643959917 no 1710 0.495122595435585 564 4207120
SGTC_1843 st055809 45.5 µM -0.0137718808279518 0.490172192389629 no 1711 0.494505988127649 556 16413835
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.0149621019687564 0.489684449694073 no 1712 0.494031207621932 556 6728940
SGTC_1807 st050092 58.9 µM -0.0156877946958983 0.489387074390817 no 1713 0.493741732111089 562 5008496
SGTC_701 4424-0219 185 µM -0.0161034795342843 0.489216737167654 no 1714 0.493575918804382 559 2911779
SGTC_1526 st051518 75 µM -0.0164807891402021 0.489062126854448 no 1715 0.493425414026514 564 673993
SGTC_971 1315-0384 26.7 µM -0.0168497868310629 0.488910924107659 no 1716 0.493278225687956 561 6769120
SGTC_2808 7946468 45.46 µM -0.0172172817803982 0.488760338717387 no 1717 0.493131637682816 562 2970879
SGTC_3236 9132701 49.47 µM -0.0175656744096968 0.488617582207194 no 1718 0.492992670151404 556 24282524
SGTC_301 4119-0100 24.5 µM -0.018567278064686 0.48820717573382 no 1719 0.492593153327901 555 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1148 3909-7663 27.7 µM -0.0192739638727738 0.487917619152079 no 1720 0.492311276944924 575 4084526
SGTC_1500 4488-1866 171 µM -0.0193616757410128 0.48788168063927 no 1721 0.492276291500713 556 2900003
SGTC_2636 apigenin dimethyl ether 100 µM -0.0203526683775061 0.487475644414858 no 1722 0.491881020591402 562 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_321 4534-3890 65.3 µM -0.0205878230537125 0.487379297136026 no 1723 0.491787227102092 559 699746
SGTC_2661 dactinomycin 12.96 µM -0.0211353644836986 0.487154962012416 no 1724 0.491568837205604 559 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2707 st078556 66.6 µM -0.0211996479881297 0.487128624457126 no 1725 0.491543197542498 556 17250899
SGTC_975 1335-0046 28.5 µM -0.0216518555648002 0.486943352360399 no 1726 0.491362834225983 565 16486740
SGTC_2011 4012611 177 µM -0.0219312242055669 0.486828894795217 no 1727 0.491251408723248 556 2049887
SGTC_1567 st069303 68.4 µM -0.022390282173041 0.486640820723458 no 1728 0.491068316056306 561 5581319
SGTC_2078 5212016 200 µM -0.0225802449862095 0.486562994643985 no 1729 0.490992551013877 559 1899708
SGTC_2353 9059630 146.67 µM -0.0227050899201079 0.486511847060512 no 1730 0.490942757857156 564 4779114
SGTC_39 0986-0283 58.349 µM -0.0261266568811287 0.485110158309138 no 1731 0.489578157600155 559 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2434 5670830 169.91 µM -0.0274123417970311 0.484583507626511 no 1732 0.48906542730897 571 1549830
SGTC_924 2046-0044 21.3 µM -0.0282016751213435 0.484260189000869 no 1733 0.488750650601621 556 3623589
SGTC_1383 3049-0032 20.7 µM -0.0283539448989659 0.484197818999468 no 1734 0.488689928032145 577 712864
SGTC_1227 3909-8010 46.6 µM -0.0288196457771475 0.484007069406731 no 1735 0.488504216161323 567 15982272
SGTC_842 0271-0008 11.1 µM -0.0289784948804184 0.483942006156184 no 1736 0.488440870994971 559 1221709
SGTC_1057 3448-5381 134 µM -0.0344300107522746 0.481709382092581 no 1737 0.486267126266604 565 5497911
SGTC_1445 4239-0156 97.7 µM -0.0347772037075676 0.481567210723394 no 1738 0.486128699219729 589 4008346
SGTC_2292 7671323 168.05 µM -0.0348914734210275 0.481520419152147 no 1739 0.486083139849651 570 937504
SGTC_786 4544-0069 423 µM -0.0355235953481922 0.481261580219978 no 1740 0.485831115939844 559 748821 YLR208W SEC13
SGTC_917 harmaline 728.087 nM -0.0355467725176547 0.481252089868423 no 1741 0.485821875423076 567 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_964 1287-0107 19.4 µM -0.0358726398606603 0.481118658151428 no 1742 0.485691956024648 563 51516812 YPR165W RHO1
SGTC_438 sphingosine 6.67 µM -0.035975656229978 0.481076476852311 no 1743 0.485650884949948 564 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2028 5153890 36.43 µM -0.0363132880307976 0.480938230913099 no 1744 0.485516277306007 575 2830968 YPR165W RHO1
SGTC_204 PMA1.184 62.41 µM -0.0364804365053292 0.480869791531196 no 1745 0.485449638866134 571 2252213 YGL008C PMA1
SGTC_1666 st014829 29 µM -0.0364812434642366 0.480869461121118 no 1746 0.485449317150256 564 3858230
SGTC_1406 3909-7906 11.9 µM -0.037349722217646 0.480513869350306 no 1747 0.485103080264813 562 X1406
SGTC_3149 9097855 49.47 µM -0.0396677705485078 0.479564839449686 no 1748 0.484178998409805 564 25236625 YMR079W SEC14
SGTC_1489 4065-0444 182 µM -0.0396990872390922 0.479552018894933 no 1749 0.484166514691241 558 2877968
SGTC_918 glabranin 770.725 nM -0.0402073844677181 0.479343933066114 no 1750 0.48396389521925 571 124049 Also referred to as licorice root.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.0413012824116018 0.478896134210629 no 1751 0.483527855363834 561 2333 A French combination drug.
SGTC_236 1509-0011 5.31 µM -0.0417938091561617 0.478694521768381 no 1752 0.483331535140171 574 3107280
SGTC_2240 6690706 185.951 µM -0.0419209889627091 0.478642462471043 no 1753 0.483280842165724 565 805876
SGTC_3032 9089427 49.47 µM -0.0424280969484564 0.478434888452551 no 1754 0.483078715192425 558 17173707
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.0435384337584975 0.477980415869188 no 1755 0.482636163925267 571 75037 A free radical scavenger.
SGTC_3335 9143315 29.6265 µM -0.0446452809246212 0.477527400131025 no 1756 0.482195024831198 566 4899691
SGTC_809 3998-0021 90 µM -0.0449191822373311 0.477415300942002 no 1757 0.482085863530809 570 715485
SGTC_3131 9127911 49.47 µM -0.0449565034516278 0.477400026681434 no 1758 0.48207098954639 584 45595681
SGTC_338 4055-0136 114 µM -0.0456465081149102 0.477117638042128 no 1759 0.481795999833379 573 2900563
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.0458134414932987 0.477049321254191 no 1760 0.481729472649028 566 5282309
SGTC_1376 2910-0861 41.3 µM -0.0458430778870596 0.477037192754262 no 1761 0.481717661847729 569 1112859
SGTC_1764 st044502 93.5 µM -0.047102120280835 0.476521957695102 no 1762 0.481215918737696 573 8407
SGTC_1752 st044819 83.042 µM -0.0474320909155432 0.476386931017819 no 1763 0.481084426471538 578 441209 YML126C ERG13
SGTC_1125 tnp00248 1.32998 µM -0.0476414066302631 0.47630127872319 no 1764 0.481001015879626 585 24207736
SGTC_2135 5326629 150.42 µM -0.0480080176682126 0.476151263594496 no 1765 0.480854926400664 570 5020077
SGTC_2488 5268135 45.7 µM -0.0486972253856345 0.475869252926748 no 1766 0.480580293537877 579 1270356 YLR208W SEC13
SGTC_984 1492-0255 2.91 µM -0.0491450214559045 0.475686029774941 no 1767 0.480401862399249 571 1585198
SGTC_1709 st033179 39.1045 µM -0.0497113064924088 0.475454332273843 no 1768 0.480176223161369 575 573381
SGTC_576 1073-0113 22.7 µM -0.0499011462992834 0.475376660507379 no 1769 0.48010058191434 578 5439563
SGTC_2678 equilin 100 µM -0.0507745338410433 0.47501933157274 no 1770 0.47975259187287 573 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.0508371071235459 0.474993731741489 no 1771 0.479727660941884 585 616764
SGTC_535 2293-4129 48.2 µM -0.0520208969492039 0.474509442057473 no 1772 0.479256021299246 606 396118 YIL048W NEO1
SGTC_953 1188-0045 9.7 µM -0.0528010155203302 0.474190315259549 no 1773 0.478945226181489 574 6144426
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.0530296738883148 0.474096780027511 no 1774 0.478854132313197 566 688669
SGTC_1715 st032160 10.2275 µM -0.0540748522996156 0.47366925650759 no 1775 0.478437763941502 567 5289825
SGTC_1203 3992-3522 103 µM -0.0551880248282029 0.473213953790101 no 1776 0.477994334599616 580 5322312
SGTC_3083 9117465 49.47 µM -0.0556800081427973 0.473012737032073 no 1777 0.477798362991117 596 16420915
SGTC_1129 3453-1384 223 µM -0.0559597923630487 0.472898310866512 no 1778 0.477686918993965 617 1084452
SGTC_1907 st060210 83.7 µM -0.0563568831297928 0.472735912505002 no 1779 0.47752875230554 586 688793
SGTC_1016 4226-1401 38 µM -0.0565189889945375 0.472669617309133 no 1780 0.477464184336452 569 2901613
SGTC_3003 9075612 71.4286 µM -0.0571345746675776 0.472417872855678 no 1781 0.477218997396937 592 6501993
SGTC_2238 6671620 73.2395 µM -0.0582369914325763 0.471967065878791 no 1782 0.476779927903735 577 729941
SGTC_72 0744-0168 198.391 µM -0.0592053994609525 0.471571088179634 no 1783 0.476394254520504 599 677577
SGTC_3026 9090633 49.47 µM -0.0592948264112655 0.471534523312113 no 1784 0.47635864089609 585 25236842
SGTC_417 st075190 100 µM -0.0593788995190363 0.471500147741115 no 1785 0.476325159572259 573 222757
SGTC_3333 9141820 12.094 µM -0.059391944362632 0.471494814021929 no 1786 0.476319964601055 584 1939433
SGTC_601 0986-0029 62.9 µM -0.0597656882029547 0.471342001433556 no 1787 0.476171126776534 579 24747981
SGTC_2682 pyrogallin 40.03 µM -0.0598681559745331 0.471300106187041 no 1788 0.476130321118064 585 822798 An ATP competetive kinase inhibitor.
SGTC_212 3807-4682 38.772 µM -0.0602008782404549 0.471164070665938 no 1789 0.47599782312531 573 3125501 YBL034C STU1
SGTC_424 splitomicin 100 mM -0.0609651133919001 0.47085162124354 no 1790 0.475693496416453 606 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_630 4356-0227 183 µM -0.0613497825798455 0.47069436010914 no 1791 0.475540322335784 580 779312
SGTC_908 3448-7491 47.7 µM -0.0619046770778136 0.470467515221419 no 1792 0.475319371437259 576 1203031
SGTC_1881 5652484 16 µM -0.0638513183224215 0.469671790452749 no 1793 0.474544307739973 605 2255129
SGTC_391 gliotoxin 8.33 µM -0.0639655432326478 0.469625102688327 no 1794 0.474498831557626 579 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_603 3794-0023 45.9 µM -0.0641446671119972 0.469551889258955 no 1795 0.474427517920933 590 3802260
SGTC_810 3825-7150 143 µM -0.0647979949366641 0.46928486286031 no 1796 0.474167418952942 571 22330411 YGL099W LSG1
SGTC_1812 st052057 4.327 µM -0.0652859339147184 0.469085442753017 no 1797 0.473973170780405 583 3645418
SGTC_3225 9130819 49.47 µM -0.0663532768780725 0.468649247999352 no 1798 0.473548283914057 583 4547121
SGTC_2869 9037858 32.47 µM -0.0665462930639203 0.468570371407349 no 1799 0.473471451414022 569 27187042
SGTC_2306 7482397 179.52 µM -0.066684303140315 0.468513973968591 no 1800 0.473416515386798 584 891448
SGTC_2114 5491910 81.25 µM -0.0668805456557363 0.468433781091812 no 1801 0.473338400337025 580 2849228
SGTC_2797 7859098 81.82 µM -0.0673870571335784 0.468226805303187 no 1802 0.473136786339283 573 972681
SGTC_2835 9006588 71.43 µM -0.0674537059322112 0.468199571242333 no 1803 0.473110257677263 580 2345538
SGTC_1180 1193-0155 285 µM -0.0690017104670249 0.46756706709714 no 1804 0.472494128995341 586 2921347
SGTC_807 1315-0151 48 µM -0.0695528525841244 0.467341893851357 no 1805 0.472274782097501 602 4011080
SGTC_2852 9023854 51.95 µM -0.0697503132890363 0.467261222338328 no 1806 0.472196197525456 577 19798528
SGTC_671 0560-0003 407 µM -0.0707772726313565 0.466841685358898 no 1807 0.471787510132611 591 3238678
SGTC_33 0986-0033 35.816 µM -0.07080992545672 0.466828346515626 no 1808 0.47177451614204 569 2848082
SGTC_1508 1080-0625 72.9 µM -0.070932834745569 0.466778137787567 no 1809 0.471725605417696 574 767111
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.0711193134683816 0.466701961808827 no 1810 0.471651398582867 578 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1560 lithocholic acid 53.1 µM -0.0724203146816501 0.466170540948577 no 1811 0.471133709231486 580 9903 A bile acid which acts as a detergent.
SGTC_159 3970-0959 50 µM -0.0745150777206979 0.465315018781509 no 1812 0.470300272116963 585 6615653
SGTC_930 2810-3379 265 µM -0.0746313708402404 0.465267528168836 no 1813 0.470254006698534 623 1015764
SGTC_1388 3346-4487 254 µM -0.0749472599477472 0.465138531056018 no 1814 0.470128337132777 595 3345614
SGTC_2072 5231554 129 µM -0.075455962520231 0.464930803953712 no 1815 0.469925967209958 577 789545
SGTC_208 k072-0098 12.366 µM -0.0760269893169293 0.464697638337253 no 1816 0.469698812981869 573 5948901
SGTC_2146 5545642 200 µM -0.0760432532937614 0.464690997494756 no 1817 0.469692343322569 590 825326
SGTC_290 2043-6722 48.1 µM -0.0764109100458348 0.464540879975979 no 1818 0.469546095011006 585 773758 YLR208W SEC13
SGTC_2594 a-mangostin 100 µM -0.0769770906474703 0.464309713283853 no 1819 0.469320884947973 585 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_484 loperamide 105 µM -0.0770037824948855 0.464298815527834 no 1820 0.469310267954432 574 3955 An opioid-receptor agonist.
SGTC_497 capsazepine 133 µM -0.0776934584704742 0.464017243709322 no 1821 0.469035948881332 580 2733484 A calcium channel blocker.
SGTC_1087 pterostilbene 9.05 µM -0.0780632416364878 0.463866280924109 no 1822 0.468888873428675 581 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2789 5281112 71.43 µM -0.078207421808738 0.463807421242137 no 1823 0.46883152917652 581 765948
SGTC_681 1642-0006 26.6 µM -0.0784152845634495 0.463722565367923 no 1824 0.468748857822332 578 4446530
SGTC_729 4092-0585 94.1 µM -0.0793755675869728 0.463330570226819 no 1825 0.468366950777191 587 2169061
SGTC_2345 9052315 157.45 µM -0.0794093106958141 0.463316796667599 no 1826 0.468353531582776 588 6469265
SGTC_2034 5197015 53.07 µM -0.0796218380184812 0.46323004640544 no 1827 0.468269013064716 596 780676
SGTC_579 4491-1009 110 µM -0.0804144787545444 0.462906518558304 no 1828 0.467953805908054 580 1271041
SGTC_316 k060-0003 58.6 µM -0.0805166488475977 0.462864818129089 no 1829 0.467913177679229 605 6152314
SGTC_593 1203-0218 61.7 µM -0.0805400582188884 0.462855263719065 no 1830 0.467903868923034 585 3666956
SGTC_1361 1608-0041 5.61 µM -0.0809789707123295 0.462676127899561 no 1831 0.467729338255589 580 X1361
SGTC_2403 6032726 181.2 µM -0.082144092538209 0.462200637001544 no 1832 0.467266065400204 588 2881040
SGTC_1686 st019653 115.5 µM -0.0832384796404358 0.461754062410697 no 1833 0.466830958279881 588 97252
SGTC_423 5-fluorouracil 457 µM -0.0834975002650239 0.461648373728987 no 1834 0.466727982476368 589 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1923 st058458 19.1 µM -0.0839532764006158 0.461462409099213 no 1835 0.466546790294523 623 3534982
SGTC_2284 7945075 39.21 µM -0.0858512262796476 0.460688103431555 no 1836 0.465792342040129 601 1245402
SGTC_1 0258-0098 57.368 µM -0.0859108647822637 0.460663775141048 no 1837 0.465768637299085 561 6790032 YDR047W HEM12
SGTC_2139 5578692 56.4705 µM -0.0861575558664839 0.460563144193652 no 1838 0.465670585352609 584 650991 YMR113W FOL3
SGTC_1460 k062-0059 9.15 µM -0.0870196250125511 0.460211506306437 no 1839 0.465327956387474 577 1373085
SGTC_2790 5423970 71.43 µM -0.0871668165377452 0.460151470005756 no 1840 0.465269457748851 595 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1443 4112-3303 14 µM -0.0883363008086385 0.459674494576455 no 1841 0.464804693921345 580 704433
SGTC_1957 st077035 62.4 µM -0.0887519328369756 0.459504992544408 no 1842 0.464639529453727 584 705593
SGTC_1775 st081588 35.1725 µM -0.0894331426706409 0.459227199156523 no 1843 0.464368842475347 587 1426443 YGL099W LSG1
SGTC_1029 k015-0030 64.7 µM -0.0906691734795031 0.458723203940719 no 1844 0.463877732855073 596 2208316
SGTC_944 3370-0224 231 µM -0.091076120346556 0.458557284630321 no 1845 0.463716053486106 590 4580514
SGTC_3296 9122258 64.045 µM -0.0914782545096675 0.458393334635294 no 1846 0.463556292083318 600 4730474
SGTC_480 am 92016 50 µM -0.0918568159075932 0.458239001717833 no 1847 0.463405901128947 639 2129 K+ channel blocker.
SGTC_1007 4101-0031 70 µM -0.0929252729351433 0.457803444350609 no 1848 0.46298146385788 631 1146276
SGTC_360 0957-0399 1.01 µM -0.0932509443573027 0.457670694185285 no 1849 0.462852101462789 611 6752301 YPR165W RHO1
SGTC_1651 st011928 86.1 µM -0.0937408234694152 0.457471018590011 no 1850 0.462657520299611 591 720198
SGTC_1206 3978-0017 132 µM -0.0952923745835322 0.456838674682734 no 1851 0.462041299646834 625 3873677
SGTC_683 panaxydol 45 µM -0.0961555173375813 0.456486942908575 no 1852 0.461698529535685 587 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_367 0335-0881 7.1 µM -0.0973308655283172 0.456008041890756 no 1853 0.461231822605374 602 23828853
SGTC_2900 5328528 85.29 µM -0.0973697411864234 0.455992202913313 no 1854 0.461216386778543 580 795359
SGTC_3210 9128157 49.47 µM -0.0974627631259675 0.455954303584117 no 1855 0.461179452064169 633 17590849
SGTC_64 000l-0018 272.079 µM -0.0976447519739568 0.455880158200207 no 1856 0.461107193669601 592 6811119
SGTC_795 0685-0265 78 µM -0.0993399971098749 0.455189560359733 no 1857 0.460434161178419 589 302754
SGTC_1824 st053723 68.6 µM -0.105734380648424 0.452585894038279 no 1858 0.45789655071334 618 675225
SGTC_1195 1502-0147 41.1 µM -0.106791862327899 0.452155501783266 no 1859 0.457477051738713 602 817940
SGTC_2216 7189485 200 µM -0.107691985190224 0.45178919842362 no 1860 0.457120013714674 594 731273
SGTC_1084 voriconazole 435 nM -0.107893578800032 0.451707165885222 no 1861 0.457040055381673 601 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1621 st003705 32.4 µM -0.108337126178585 0.451526684703432 no 1862 0.456864136741085 599 24207032
SGTC_827 3253-0474 693 µM -0.110313143371257 0.450722757753169 no 1863 0.456080516989066 605 5402065
SGTC_896 0964-0007 44.5 µM -0.110433959176497 0.450673611322608 no 1864 0.456032611148915 591 6756758
SGTC_558 k064-0027 21.3 µM -0.111179762011215 0.450370244384987 no 1865 0.455736899851329 607 5088526
SGTC_1295 1013-0063 9.78 µM -0.112024776732129 0.450026556511305 no 1866 0.455401880614832 599 6826038
SGTC_2778 tioconazole 65.09 nM -0.112999840292368 0.449630021225989 no 1867 0.455015340915868 619 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1981 st071826 47 µM -0.113711839877412 0.44934049958429 no 1868 0.454733113269668 590 11838600
SGTC_22 0964-0034 14.468 µM -0.114745033722018 0.448920418158802 no 1869 0.454323608947242 596 138402
SGTC_1984 st072354 53.1 µM -0.115024912678978 0.448806633326009 no 1870 0.454212687818356 605 5762938
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.115524012425895 0.448603734702659 no 1871 0.45401489436426 596 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1491 4138-0063 26.5 µM -0.115946112399552 0.448432149225281 no 1872 0.453847624853659 599 23883227
SGTC_2304 7443016 91.4 µM -0.116446586870867 0.448228716675042 no 1873 0.453649307756244 602 939854
SGTC_3056 9094900 49.47 µM -0.118469309782571 0.447406660776511 no 1874 0.452847905532805 608 25236784
SGTC_1949 st076024 69.1 µM -0.119058024414104 0.447167443230019 no 1875 0.452614692901542 587 2921930
SGTC_950 1165-0508 94.1 µM -0.121617310629215 0.446127730659005 no 1876 0.451601051679531 606 6148369
SGTC_1827 berberine 7.24 µM -0.121704788523356 0.446092199181783 no 1877 0.451566410370102 592 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_394 menadione 8.33 µM -0.123134071444993 0.445511719366096 no 1878 0.451000465727621 609 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1967 st070177 51.4 µM -0.124080897784262 0.445127245611294 no 1879 0.45062561131357 619 5729214
SGTC_2453 5731132 22.18 µM -0.124497090038305 0.444958260495783 no 1880 0.45046085213477 623 1362040
SGTC_2645 abamectin 100 µM -0.125130408851508 0.444701135427397 no 1881 0.450210154852631 595 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1261 0712-0010 12.7 µM -0.125170636808243 0.444684803812257 no 1882 0.450194231411076 615 2840123
SGTC_373 0844-0104 25.9 µM -0.125594935754376 0.444512554028754 no 1883 0.450026285947305 611 5375804
SGTC_557 1315-0110 16.2 µM -0.126651311966812 0.444083749687073 no 1884 0.449608191414309 596 6833801
SGTC_995 3931-2021 34.6 µM -0.12780646826069 0.44361492345571 no 1885 0.449151065557856 621 730143
SGTC_2095 5432005 200 µM -0.128063027282718 0.443510808318997 no 1886 0.449049547513684 599 783734
SGTC_2223 6903751 107.57 µM -0.1285951760363 0.443294867565263 no 1887 0.448838991790085 599 5598863
SGTC_849 0386-0493 241 µM -0.128682162969793 0.443259570718981 no 1888 0.44880457496898 607 726119
SGTC_3064 1327-0027 10 µM -0.129175980600691 0.443059201981327 no 1889 0.448609200829392 598 16000455 YPR107C YTH1
SGTC_3244 9134489 49.47 µM -0.129442974894438 0.442950873899949 no 1890 0.448503572323205 643 16584271
SGTC_1034 k072-0165 12.7 µM -0.130464243063735 0.442536552325517 no 1891 0.448099571105904 650 5835461
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.131177828275328 0.442247092907963 no 1892 0.447817317428554 638 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1701 st028638 40.4 µM -0.131924701164863 0.441944163668179 no 1893 0.447521925340554 609 3490878
SGTC_329 k048-0121 21.3 µM -0.133539987315825 0.44128912514588 no 1894 0.446883171071074 613 6832902
SGTC_1814 st052110 31.539 µM -0.134345432093085 0.440962557230855 no 1895 0.44656471461225 639 674163
SGTC_277 nystatin 15.5 µM -0.134631993170201 0.440846380594516 no 1896 0.446451422499289 640 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1437 4092-1038 11.6 µM -0.134697607090866 0.440819780333511 no 1897 0.446425482606623 612 3977136
SGTC_623 k072-0108 16.9 µM -0.135675032035412 0.440423558316985 no 1898 0.446039093363572 628 5382803
SGTC_1485 3909-9022 254 µM -0.136311773109557 0.440165472518852 no 1899 0.445787408580584 608 714516
SGTC_1753 st043925 64 µM -0.136553914219971 0.440067333824776 no 1900 0.445691703138676 614 670181
SGTC_499 genistein 192 µM -0.137053701815723 0.439864783828265 no 1901 0.445494173821385 611 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_730 1436-0052 41.2 µM -0.137093492237017 0.439848658554139 no 1902 0.445478448172071 604 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1994 st072947 40.9 µM -0.137589802089305 0.439647534811313 no 1903 0.445282307811837 644 5286565 YDL195W SEC31
SGTC_2278 7948257 134.34 µM -0.139622952728256 0.438823787520791 no 1904 0.44447895230308 594 1247028
SGTC_1145 3546-0597 10.2 µM -0.139739911684722 0.438776408685253 no 1905 0.444432745405334 603 875334
SGTC_2754 granisetron 64.02 µM -0.140482464698803 0.438475628810165 no 1906 0.444139403119183 629 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2589 lobaric acid 100 µM -0.14089743223533 0.438307556770157 no 1907 0.443975485345699 613 73157 A novel microtubule depolymerizer.
SGTC_2809 7964133 12.99 µM -0.140985790657165 0.438271770875827 no 1908 0.44394058381404 637 1253665
SGTC_1713 st033146 12.748 µM -0.141236923129311 0.438170062896803 no 1909 0.443841388990182 647 674619
SGTC_2902 5787006 60.46 µM -0.141569577388897 0.43803534510086 no 1910 0.44370999929052 629 591003
SGTC_1496 4469-0713 57.4 µM -0.142159979227619 0.437796262790444 no 1911 0.443476821308674 639 746691
SGTC_2592 piperlongumine 83.33 µM -0.142387287582217 0.437704220673392 no 1912 0.443387051558814 623 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2620 irigenin 100 µM -0.146275969478319 0.436130134585603 no 1913 0.441851767687541 596 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2876 9059903 25.97 µM -0.147821073756602 0.435504976455038 no 1914 0.441241988797139 602 6916095
SGTC_3168 9103419 49.47 µM -0.147831575218957 0.435500728052199 no 1915 0.441237844846161 615 16649256
SGTC_2815 7968870 71.43 µM -0.14835641461194 0.435288411957352 no 1916 0.441030747731217 640 2977326 YHR190W ERG9
SGTC_1372 2752-0194 270 µM -0.148837470565494 0.435093824195294 no 1917 0.440840941346919 612 823334
SGTC_1805 st050013 60.3 µM -0.149719141271409 0.434737228077855 no 1918 0.440493102925456 622 4037144
SGTC_2277 7947813 106.88 µM -0.150079676630049 0.434591423027859 no 1919 0.440350877033902 648 1246798
SGTC_398 bronopol 33.3 µM -0.150892126502289 0.434262890683632 no 1920 0.440030405756829 625 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2409 alverine citrate 63.97 µM -0.151222570150457 0.434129281350522 no 1921 0.439900073313701 613 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2483 5729050 27.16 µM -0.151998690307937 0.433815499832197 no 1922 0.439593984316258 639 2865180
SGTC_331 k048-0133 24.5 µM -0.15401698718703 0.432999708166048 no 1923 0.438798170780152 609 6813582
SGTC_1012 4112-3522 18 µM -0.154695782140569 0.432725404540242 no 1924 0.438530577664875 630 3112398
SGTC_2701 st077767 14.721 µM -0.155313975221739 0.432475618562062 no 1925 0.438286899335627 636 5721188
SGTC_2413 inermin 26.06 µM -0.155438620030167 0.432425258071889 no 1926 0.438237769881805 657 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_443 clozapine 122 µM -0.155980682986581 0.432206260074591 no 1927 0.438024123792544 609 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_203 k066-0004 30.888 µM -0.158058676142077 0.431366926886967 no 1928 0.43720528143861 607 6795412
SGTC_2144 5628481 200 µM -0.159754019486983 0.430682381112183 no 1929 0.43653742295578 599 2818399
SGTC_300 r073-0011 5.04 µM -0.161754656547093 0.429874831829071 no 1930 0.435749530766696 612 2735780
SGTC_2430 5571206 200 µM -0.162037941151609 0.429760508739015 no 1931 0.435637987972724 622 1731771
SGTC_1970 st070122 35.8 µM -0.164594123696343 0.428729196364784 no 1932 0.434631728372125 661 102928
SGTC_2000 st075254 36.4 µM -0.167088903102179 0.427723126550883 no 1933 0.4336500486559 614 17234175
SGTC_368 fentichlor 4.58 µM -0.170542609845357 0.426331126648985 no 1934 0.432291713667171 643 7329 A pesticide.
SGTC_2442 5158906 48.48 µM -0.171153569679726 0.426084977212832 no 1935 0.432051507367449 606 1893835
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.171605379930758 0.425902966022706 no 1936 0.431873888814583 617 16623 A steroid.
SGTC_1737 st035557 69.7 µM -0.173239896101948 0.425244635365346 no 1937 0.431231432580999 609 5716916
SGTC_1744 st037937 38.9 µM -0.173272050710019 0.425231686605244 no 1938 0.431218795841286 653 1016152
SGTC_3282 9108498 15.4605 µM -0.174151667944211 0.424877493353768 no 1939 0.430873134199665 643 16459645
SGTC_2780 5215298 71.43 µM -0.174362663736717 0.42479254121715 no 1940 0.430790227416884 672 2834131
SGTC_556 4058-0063 51.5 µM -0.174916270913891 0.424569661858678 no 1941 0.430572712517433 640 6615692
SGTC_1919 st067113 52.3 µM -0.176029241696719 0.42412165867785 no 1942 0.430135484790873 635 1268243
SGTC_26 0302-0163 425.158 µM -0.176757003556175 0.423828766289708 no 1943 0.429849631686697 651 3100915
SGTC_211 3455-0679 143.504 µM -0.17729302368593 0.423613068477033 no 1944 0.429639115142803 629 748649
SGTC_2939 9044578 71.43 µM -0.177367144323351 0.423583243674262 no 1945 0.429610006576997 627 2653634
SGTC_1314 1222-0010 41.1 µM -0.181190911626711 0.422045226588885 no 1946 0.428108864003327 626 3526027
SGTC_3328 9140624 29.0385 µM -0.182204279501279 0.421637822286977 no 1947 0.427711207327604 624 4904392
SGTC_1151 3909-8316 15.3 µM -0.182448721953308 0.421539561622322 no 1948 0.427615296402318 670 800431
SGTC_3209 9113616 49.47 µM -0.183744309921793 0.421018844536009 no 1949 0.427107023184709 671 16649353
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.18656525876831 0.419885540036752 no 1950 0.4260007539569 642 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1353 1498-1206 8.11 µM -0.186663508650228 0.419846080466802 no 1951 0.425962234516813 631 6756808
SGTC_1510 1123-0200 71.5 µM -0.187583446628301 0.419476649888525 no 1952 0.425601601781252 684 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_3181 9108277 49.47 µM -0.187628650696884 0.419458498572628 no 1953 0.42558388255024 653 17097298
SGTC_1950 st077106 7.18 µM -0.189228832901468 0.418816069473834 no 1954 0.424956735245936 600 13831864
SGTC_256 clotrimazole 625 nM -0.189509873926412 0.418703261535961 no 1955 0.424846608521554 623 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_207 4185-0010 4.486 µM -0.190533603512073 0.418292400101003 no 1956 0.424445506830691 617 3761753
SGTC_197 4544-0043 41.561 µM -0.190964950507081 0.418119310889291 no 1957 0.42427652660928 624 896523
SGTC_1114 scopoletin 1.73284 µM -0.191691150082923 0.417827940240638 no 1958 0.423992069322171 637 5280460 A coumarin with genotoxic properties.
SGTC_2821 7996764 71.43 µM -0.191725227280251 0.417814268666331 no 1959 0.423978722024903 610 2987135
SGTC_923 1900-2434 73.3 µM -0.192277111400512 0.417592869793346 no 1960 0.42376257316701 641 5910570
SGTC_2625 euphol 100 µM -0.193429355028387 0.417130709493425 no 1961 0.423311363768418 617 6708538 A triterpene alcohol.
SGTC_97 0535-0701 19.132 µM -0.194006458589423 0.416899278556331 no 1962 0.423085412381953 620 2832013 YGL099W LSG1
SGTC_744 1594-0068 283 µM -0.194723782259175 0.416611656488422 no 1963 0.422804596366073 629 668392
SGTC_1088 bifonazole 369 nM -0.196207125115531 0.41601702888506 no 1964 0.422224025707856 619 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1610 st001799 48.1 µM -0.203403378351085 0.413135018984329 no 1965 0.419409879731172 628 621897
SGTC_136 0097-0015 404.482 µM -0.204965434275355 0.412510047192273 no 1966 0.418799565555768 638 4861337
SGTC_2534 helenine 20.12 µM -0.206995842506391 0.411698021340081 no 1967 0.418006552693339 608 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1357 1503-1303 39.5 µM -0.207712737927615 0.411411401820817 no 1968 0.417726635584524 635 292895
SGTC_1258 0671-0043 57.1 µM -0.208307406243528 0.411173685367746 no 1969 0.417494474570822 677 4298767
SGTC_3300 9124615 50.48 µM -0.20838572247359 0.41114238117371 no 1970 0.417463901726237 651 24824903
SGTC_2108 5365811 200 µM -0.20899495224904 0.410898882057017 no 1971 0.41722608956592 616 780283
SGTC_1466 k213-0079 57.5 µM -0.20929793972858 0.410777795723411 no 1972 0.417107830010835 647 3657981
SGTC_2526 patulin 37.61 µM -0.213379068272183 0.40914764093643 no 1973 0.415515652829299 642 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_537 1334-0398 209 µM -0.214469644951729 0.408712288638435 no 1974 0.415090418022285 656 5846986
SGTC_409 arachidonic acid 100 µM -0.216380680370299 0.407949685528746 no 1975 0.414345512198432 649 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_296 1222-0039 74.9 µM -0.218001050485755 0.407303346043799 no 1976 0.4137141464706 652 5984176
SGTC_230 MPP+ 141.667 µM -0.219853405902123 0.4065647805217 no 1977 0.412992662564831 666 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_643 k048-0106 28.4 µM -0.220770359106322 0.406199298505034 no 1978 0.412635622068581 648 6763920
SGTC_1913 st060213 96.1 µM -0.220951861324639 0.406126964473672 no 1979 0.412564957837028 681 688959
SGTC_1074 carmofur 3.8 µM -0.222416705212656 0.405543298108752 no 1980 0.411994754302192 648 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1931 st074438 57.1 µM -0.224017855939959 0.404905560552497 no 1981 0.411371704632394 675 2787313
SGTC_905 2-aminofluorene 215 µM -0.224582601876499 0.404680682664724 no 1982 0.4111520004276 631 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1359 1582-0056 520 nM -0.225246211684356 0.404416478107222 no 1983 0.410893870631993 659 3661189
SGTC_229 benomyl 22.8748 µM -0.22524730639122 0.404416042304938 no 1984 0.410893444846655 655 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_3087 9117406 49.47 µM -0.226306283150377 0.403994519785331 no 1985 0.410481605951683 639 42546093
SGTC_1534 6-azauridine 81.6 µM -0.226659269681431 0.403854039299694 no 1986 0.410344350453609 645 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2082 5219693 150 µM -0.229647749424754 0.402665192038064 no 1987 0.409182749817003 668 2834649
SGTC_2196 6573537 42.6665 µM -0.231233293395127 0.402034811213573 no 1988 0.408566783194966 670 2903087
SGTC_1509 1326-1131 80 µM -0.23180530477901 0.401807453280662 no 1989 0.408344618327155 623 768313
SGTC_693 4161-2696 114 µM -0.234794561025925 0.400619852859837 no 1990 0.407184094712745 647 805759
SGTC_1562 morin hydrate 59.1 µM -0.234808597373173 0.400614278522091 no 1991 0.407178647272747 673 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_851 0394-0702 453 µM -0.235209862986312 0.400454930096034 no 1992 0.407022925582628 644 762646
SGTC_650 1328-0195 38 µM -0.235257979231643 0.400435823545288 no 1993 0.407004253792627 659 2780821
SGTC_1407 3909-7909 12.3 µM -0.235464079953111 0.400353985402652 no 1994 0.406924277596142 643 4411780
SGTC_2873 9040596 71.43 µM -0.236354941265072 0.400000293994505 no 1995 0.40657862868647 707 6463863
SGTC_3146 9095609 49.47 µM -0.237667183521013 0.39947945460195 no 1996 0.406069619086928 647 17173999
SGTC_369 0957-0393 4.5 µM -0.237700288785674 0.399466317168023 no 1997 0.406056779835321 703 6997992
SGTC_1688 st021091 57.6 µM -0.24144480865686 0.397981086660899 no 1998 0.40460519374136 681 3656366
SGTC_577 r071-0003 38.6 µM -0.24194414537769 0.397783140349032 no 1999 0.404411721507806 639 4568517 YMR134W ERG29
SGTC_700 3453-2283 142 µM -0.242595218345135 0.397525082510018 no 2000 0.404159492894507 643 565664
SGTC_2431 5490079 200 µM -0.243260628097147 0.397261388508074 no 2001 0.403901751307861 697 5722345
SGTC_933 2914-0560 114 µM -0.243686611859495 0.397092600832385 no 2002 0.403736771516985 663 463887
SGTC_82 0054-0107 293.755 µM -0.245057442984857 0.396549566951236 no 2003 0.403205976961613 650 3104697
SGTC_1748 st037455 53.6035 µM -0.245903133342114 0.396214659569856 no 2004 0.402878609119699 675 580690
SGTC_2379 9035213 200 µM -0.246415501286709 0.39601179061807 no 2005 0.402680303919219 633 646551
SGTC_1862 st057513 3.81 µM -0.246531230622749 0.395965972192592 no 2006 0.402635515882739 646 5393163
SGTC_981 1488-1094 54.9 µM -0.246844757636154 0.395841850870712 no 2007 0.402514185227897 633 3449522
SGTC_1342 1486-1464 234 µM -0.247336685089685 0.395647124392757 no 2008 0.402323834977462 657 3253938
SGTC_2679 rapamycin 1 nM -0.247817648315318 0.395456763218058 no 2009 0.402137749701007 669 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_859 0439-0102 54.6 µM -0.248019059918357 0.395377053616429 no 2010 0.4020598298848 667 610143
SGTC_1389 3405-0187 19 µM -0.248032771306105 0.395371627428479 no 2011 0.402054525521482 646 799890
SGTC_3132 9126706 49.47 µM -0.248446770961926 0.395207799452944 no 2012 0.401894374843321 678 850858
SGTC_1766 st045414 44.774 µM -0.24864211919943 0.395130502663169 no 2013 0.401818812497049 650 253960
SGTC_2293 7624732 200 µM -0.25013920477437 0.394538262325632 no 2014 0.401239849205889 651 894453
SGTC_938 3126-1755 342 µM -0.251617502385353 0.393953693510758 no 2015 0.400668364427054 668 1777771
SGTC_2968 9090663 33.37 µM -0.252257614390182 0.393700645625443 no 2016 0.400420973854602 707 25236811
SGTC_3177 9107506 49.47 µM -0.252690663255465 0.393529479001052 no 2017 0.400253631718041 657 8897194
SGTC_2024 5144227 134 µM -0.252917035204994 0.393440011551494 no 2018 0.40016616258092 664 3475211
SGTC_2179 6298986 200 µM -0.25470780547538 0.392732456229916 no 2019 0.399474393574355 663 738374
SGTC_2 0422-0095 29 µM -0.254751601088014 0.39271515647505 no 2020 0.399457479408282 652 6790840
SGTC_214 4373-3496 70 µM -0.254935357250514 0.392642573054466 no 2021 0.399386513574918 682 3779166
SGTC_1217 1183-1422 255 µM -0.255128746893411 0.392566188455322 no 2022 0.399311830923604 646 2849664
SGTC_1633 st005664 67.9 µM -0.256152807757976 0.392161776275996 no 2023 0.398916423547906 687 2063822
SGTC_969 1313-0238 134 µM -0.257277675210057 0.391717688760926 no 2024 0.398482212566926 654 5212874
SGTC_2773 thioridazine 9.09 µM -0.257964058990908 0.391446779899343 no 2025 0.398217322708374 646 5452 An antipsychotic.
SGTC_440 fluspirilene 35.1 µM -0.258305278657898 0.391312123467852 no 2026 0.39808565634625 676 3396 An atypical antipsychotic.
SGTC_62 0180-0423 3.232 µM -0.258961890389966 0.391053039682047 no 2027 0.397832322376362 678 30102 YGL099W LSG1
SGTC_1190 1486-1332 13 µM -0.260715010669117 0.39036153614527 no 2028 0.397156144729264 670 4150046
SGTC_2919 7978188 46.38 µM -0.261585565959514 0.390018281627569 no 2029 0.396820486665743 626 2980291
SGTC_1411 3909-8223 150 µM -0.262961721875301 0.389475846930192 no 2030 0.396290041290595 683 X1411
SGTC_1634 st006576 41 µM -0.263746914892982 0.389166446448821 no 2031 0.395987471106428 671 3915356
SGTC_2523 spermine 47.74 µM -0.264188650244472 0.38899241421934 no 2032 0.395817278135807 646 1103 A DNA binding polyamine.
SGTC_2627 acetyl isogambogic acid 100 µM -0.266026500244036 0.388268588608978 no 2033 0.39510939995943 677 6857789 A caspase activator and apoptosis inducer.
SGTC_1906 st060206 94.7 µM -0.266284707946044 0.388166926157173 no 2034 0.395009974683235 682 5133468
SGTC_71 0417-1750 47.813 µM -0.266504251186811 0.388080492841246 no 2035 0.39492544289419 628 6811472
SGTC_1942 st076330 65.2 µM -0.266663885136348 0.388017649059827 no 2036 0.394863981372717 706 24208414
SGTC_3270 9137563 49.47 µM -0.268365084096123 0.387348113226155 no 2037 0.394209156449562 643 17015724
SGTC_628 1636-0253 16 µM -0.26941172173828 0.386936357443289 no 2038 0.393806433442892 692 4456143
SGTC_1930 st074634 34.3 µM -0.270624934491336 0.386459228870235 no 2039 0.393339758132583 689 684253 YOR116C RPO31
SGTC_199 4063-0024 41.6 µM -0.27270433537165 0.385641847988942 no 2040 0.392540250918173 682 306215
SGTC_762 1165-0429 115 µM -0.273015999893139 0.385519381054313 no 2041 0.392420458249768 674 5967793
SGTC_357 1325-0123 420 µM -0.273382632054352 0.385375329485275 no 2042 0.392279551039802 705 1098503
SGTC_348 k064-0012 10.7 µM -0.273588268146741 0.385294540979331 no 2043 0.392200525397629 663 5066323
SGTC_763 3453-1109 128 µM -0.275541844847092 0.384527285617717 no 2044 0.391449990978661 688 1560353
SGTC_2363 9053361 176 µM -0.275553128883895 0.384522855191352 no 2045 0.391445656994222 695 6469797 YMR079W SEC14
SGTC_2891 9063876 19.48 µM -0.275684393806084 0.384471318044237 no 2046 0.391395241618459 653 6472478
SGTC_1081 sertraline 6 µM -0.276810391724981 0.384029313457192 no 2047 0.390962850706677 669 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_965 1291-5240 308 µM -0.278911751865069 0.383204839248044 no 2048 0.390156274802061 697 2834598
SGTC_2640 pentamidine 10.38 µM -0.280546607611796 0.382563764750528 no 2049 0.389529086380538 695 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2586 curcumin 80 µM -0.28176080121515 0.382087852178842 no 2050 0.389063464848118 681 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1001 4048-4355 44.4 µM -0.282997936734593 0.381603130523476 no 2051 0.388589209315201 702 21824233
SGTC_926 2268-1401 59.4 µM -0.28308923602479 0.38156736592428 no 2052 0.388554216329119 665 2931578
SGTC_2617 dihydrotanshinone i 20.83 µM -0.283165495939027 0.381537493462996 no 2053 0.388524988294344 643 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1924 st058459 75.1 µM -0.283339471861319 0.381469346421032 no 2054 0.388458311139189 679 688683
SGTC_536 3852-0578 10.6 µM -0.284209690385892 0.381128533652061 no 2055 0.388124844846412 671 2869208
SGTC_2377 9073351 62.6 µM -0.284917496922973 0.38085139595285 no 2056 0.387853675361266 710 7337946 YHR072W ERG7
SGTC_2236 dapsone 200 µM -0.286713757225522 0.380148354912229 no 2057 0.387165751455342 670 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2906 7926292 26.41 µM -0.28687925861305 0.380083598953021 no 2058 0.387102386248304 716 2966319
SGTC_1184 1269-1718 139 µM -0.28717789211096 0.379966760713233 no 2059 0.386988056611835 650 5403821
SGTC_3211 9128781 49.47 µM -0.28779502109968 0.379725348090904 no 2060 0.386751824397378 697 17194361
SGTC_667 1498-1044 59 µM -0.287846745352792 0.379705116381143 no 2061 0.386732026656775 680 6739982
SGTC_670 4204-0025 119 µM -0.289009583445675 0.379250364491027 no 2062 0.386287021914059 692 719039
SGTC_2325 6158266 200 µM -0.289208914554686 0.379172428690699 no 2063 0.386210755192334 662 3623240
SGTC_2181 6316240 54.2555 µM -0.292012733850646 0.378076694529596 no 2064 0.385138443944826 661 12779990
SGTC_2995 9067767 71.4286 µM -0.292414246418962 0.377919863205485 no 2065 0.384984958470148 694 11673567
SGTC_1391 3442-0225 151 µM -0.29255440968939 0.377865119988355 no 2066 0.384931382755236 652 5227075
SGTC_1418 3966-3099 2.4 µM -0.293257162144792 0.37759068472074 no 2067 0.384662797267851 678 740335
SGTC_11 0438-0307 1.3 µM -0.293396662390449 0.377536215149149 no 2068 0.384609488144328 677 4011476
SGTC_1394 3474-0001 65.7 µM -0.294291881537424 0.377186723929575 no 2069 0.384267437861024 660 5017666 YIL048W NEO1
SGTC_1954 st077032 68.9 µM -0.294414789372844 0.377138748876949 no 2070 0.384220483584318 718 698907
SGTC_1468 k284-1086 134 µM -0.295922359436212 0.376550448189661 no 2071 0.383644687521301 676 15996457
SGTC_3237 9133362 49.47 µM -0.297439454646343 0.375958719805697 no 2072 0.383065512717425 713 43845137
SGTC_627 1391-0720 175 µM -0.29813393708095 0.375687940806452 no 2073 0.382800470304992 687 997839
SGTC_668 1682-0499 62.6 µM -0.299246664144386 0.37525421570854 no 2074 0.382375923369084 664 682214
SGTC_1091 telmisartan 47.6 µM -0.299508192829844 0.375152298429085 no 2075 0.382276160903605 695 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1368 1852-0141 284 µM -0.300721955171529 0.374679411521205 no 2076 0.381813262745082 696 2838987
SGTC_1252 0493-0875 34.8 µM -0.300844602556247 0.374631638053467 no 2077 0.38176649753168 666 3960963
SGTC_3314 9135860 59.4275 µM -0.301429405917056 0.374403872596264 no 2078 0.381543536867624 660 25252478
SGTC_2174 5790901 200 µM -0.301504171167129 0.37437475666461 no 2079 0.38151503488758 684 786020
SGTC_598 3937-0236 20.2 µM -0.301795150476615 0.374261447022858 no 2080 0.381404113983897 678 1379313
SGTC_505 gw-5074 63.9 µM -0.3031054705735 0.373751332725608 no 2081 0.380904742616724 677 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1161 k007-0610 110 µM -0.303158331266727 0.373730758421399 no 2082 0.380884601224434 694 5843850
SGTC_2740 felodipine 17.08 µM -0.303455570623367 0.373615074378824 no 2083 0.380771350785625 667 3333 L-type calcium channel blocker
SGTC_1852 st056254 31.4 µM -0.30349809311261 0.373598525773528 no 2084 0.380755150231165 682 442583
SGTC_2142 5622915 118.518 µM -0.303905186886607 0.373440107663039 no 2085 0.380600063009464 657 5322196
SGTC_415 dibenzyl ketone 100 µM -0.304022723409602 0.373394373004807 no 2086 0.380555289639486 696 7593
SGTC_3329 9141233 27.5565 µM -0.304379745278345 0.373255463097522 no 2087 0.380419298558395 719 4909101 YNL103W MET4
SGTC_2218 6965428 192.983 µM -0.305892271175673 0.37266715310738 no 2088 0.379843335398261 674 675684
SGTC_1863 st057641 20.1 µM -0.306409942508566 0.372465868510848 no 2089 0.379646269584103 674 3921635
SGTC_1677 st019204 53.9 µM -0.308702128357563 0.371575023980361 no 2090 0.37877406233068 687 3945625
SGTC_1734 st037168 69.4 µM -0.309144645070316 0.371403121477897 no 2091 0.378605749747856 694 708907
SGTC_2310 7668677 200 µM -0.309679027176512 0.371195566622352 no 2092 0.378402526574437 719 2197143
SGTC_272 doxorubicin 8.13 µM -0.310597293130102 0.370838998185906 no 2093 0.378053392626235 668 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1421 4029-0249 71.4 µM -0.311418809708732 0.370520092105219 no 2094 0.377741128135449 705 2894095
SGTC_611 3453-1652 23.7 µM -0.311610229077423 0.370445797427336 no 2095 0.377668379693723 685 1560575
SGTC_1791 st048313 56.1 µM -0.313251862047646 0.369808837004776 no 2096 0.377044659708936 666 1204976
SGTC_1545 lovastatin 49.4 µM -0.313682273703096 0.369641894496204 no 2097 0.376881182637032 665 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2275 7947463 200 µM -0.314109991891149 0.369476021034238 no 2098 0.376718750449298 657 1225414
SGTC_193 1273-0060 1.558 µM -0.314795858573334 0.369210085680943 no 2099 0.376458328187869 711 2847393 YHR072W ERG7
SGTC_2386 9075165 157.42 µM -0.315484583023342 0.36894310523897 no 2100 0.376196877410687 687 16452277
SGTC_495 decylubiquinone 155 µM -0.316748335412202 0.368453382733181 no 2101 0.375717284683056 711 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1800 st050079 29.0735 µM -0.31678620163732 0.368438712310173 no 2102 0.375702917447975 686 3645560
SGTC_2120 5538279 151.968 µM -0.317047496920099 0.368337484518885 no 2103 0.375603781270101 682 2058197
SGTC_1876 myriocin 605 nM -0.317346749243477 0.368221563106367 no 2104 0.375490254171298 712 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2364 9055074 200 µM -0.318725324263184 0.367687699390071 no 2105 0.374967404710105 708 6470630
SGTC_1172 0370-0043 85 µM -0.320767944011148 0.366897149361803 no 2106 0.374193126844347 692 376585
SGTC_35 0133-0054 64.071 µM -0.320909968796614 0.366842202801509 no 2107 0.374139309584217 703 99677
SGTC_16 erodoxin 22.806 µM -0.32092700845199 0.366835610681549 no 2108 0.374132852935392 701 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_426 0988-0037 14.6 µM -0.321026385019046 0.366797165718643 no 2109 0.374095197971506 721 5383008
SGTC_3259 9138485 49.47 µM -0.32191981230652 0.366451593184998 no 2110 0.37375672172664 675 17646153
SGTC_3007 9078383 71.4286 µM -0.321953098229503 0.366438720471506 no 2111 0.373744113184895 689 6496995
SGTC_2621 lithochol-11-enic acid 100 µM -0.322450676423942 0.366246309251017 no 2112 0.373555649158277 721 6708711
SGTC_648 0375-0473 33.3 µM -0.323137157463771 0.365980905362889 no 2113 0.373295685434065 700 1713139
SGTC_1050 3232-1156 69.3 µM -0.323302499393745 0.365916991264 no 2114 0.373233080658039 696 700529
SGTC_3155 9099265 49.47 µM -0.324015341034009 0.365641479881862 no 2115 0.372963209894229 711 25236499
SGTC_1156 4092-0367 4.88 µM -0.324732167313113 0.365364498323622 no 2116 0.372691893457167 678 1357585
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.324908149265522 0.365296509653695 no 2117 0.372625294504968 677 5106787 A p450 inhibitor.
SGTC_3144 9087057 49.47 µM -0.325488741196764 0.36507223445022 no 2118 0.372405601180522 753 17249618
SGTC_1160 4092-0570 10.5 µM -0.32569170829376 0.3649938417506 no 2119 0.372328809151179 673 4994975
SGTC_1714 st033236 13.627 µM -0.326203745384969 0.364796100933773 no 2120 0.372135103922664 712 2916566
SGTC_2533 agelasine 13.65 µM -0.327496303858463 0.364297094880307 no 2121 0.371646269034082 693 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_516 3992-2719 87.3 µM -0.32762644028755 0.364246867043584 no 2122 0.371597063967643 677 5350887 YDR037W KRS1
SGTC_2085 5307070 144.047 µM -0.32767709575944 0.364227316539848 no 2123 0.371577911513054 712 2840351
SGTC_2845 9003024 42.97 µM -0.328353271783678 0.363966379929433 no 2124 0.371322284883277 677 2990173
SGTC_2795 7780010 54.55 µM -0.328471737153086 0.363920670582629 no 2125 0.371277505190236 677 953673
SGTC_1294 1000-1494 117 µM -0.335294575480767 0.361291394041773 no 2126 0.368701442643679 678 712797 YDL207W GLE1
SGTC_2286 7945697 125 µM -0.336509432505502 0.360823914058131 no 2127 0.36824336989664 704 1245733
SGTC_2448 5185112 27.17 µM -0.338659658112261 0.35999701183622 no 2128 0.367433067357953 669 5718189
SGTC_2561 acetosyringone 100 µM -0.338881557622239 0.359911714183017 no 2129 0.367349479077505 711 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_800 3448-7362 155 µM -0.33928171336327 0.359757912885921 no 2130 0.3671987585807 709 15991913
SGTC_132 0417-1715 25.805 µM -0.339409786221545 0.359708692418421 no 2131 0.367150523672063 715 6769098
SGTC_1947 st076332 61.6 µM -0.339842489688618 0.359542414704094 no 2132 0.366987574037451 711 24208416
SGTC_2164 5685496 200 µM -0.342292747203756 0.358601341077151 no 2133 0.366065296595198 694 759046
SGTC_2537 larixol 68.93 µM -0.342471855807816 0.358532584179924 no 2134 0.365997910345016 697 6708759
SGTC_1772 st048439 82.2 µM -0.343371255622667 0.358187388499056 no 2135 0.365659590576535 678 2927068 YDL195W SEC31
SGTC_261 5-fluorouridine 15.376 µM -0.345134050574215 0.35751115234976 no 2136 0.364996797872857 686 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_285 1486-1325 46 µM -0.345216782066817 0.357479426203314 no 2137 0.364965701575146 686 22310230
SGTC_2928 9011484 9.79 µM -0.347462011888034 0.356618794779528 no 2138 0.364122126452897 713 2994751
SGTC_1031 k035-0009 16 µM -0.347683820375883 0.356533811667891 no 2139 0.364038824470998 729 5180959
SGTC_2113 5491891 107.031 µM -0.349924526228137 0.355675713654957 no 2140 0.363197670002753 718 789979
SGTC_1985 st071382 65.5 µM -0.350706725628765 0.355376335390964 no 2141 0.362904189671779 727 6123237
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.351263992808626 0.355163101887822 no 2142 0.362695152749963 689 368090
SGTC_320 4092-0846 5.34 µM -0.351373100312638 0.355121358144183 no 2143 0.362654230137702 681 1359356
SGTC_2398 5228213 48.84 µM -0.351968818903931 0.354893471184551 no 2144 0.362430823496236 709 80771 YMR134W ERG29
SGTC_2629 bisabolol 100 µM -0.353379545534664 0.354354017129758 no 2145 0.36190195910678 733 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2825 7998094 58.44 µM -0.353599525602934 0.354269924266167 no 2146 0.361819514965995 709 2987815
SGTC_1547 harmine 94.2 µM -0.3548290943804 0.35380002190817 no 2147 0.361358815311274 680 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_3352 9151559 45.5865 µM -0.357521342053148 0.352771908151678 no 2148 0.360350775946881 678 17159339
SGTC_951 1171-0579 82.7 µM -0.357825160875816 0.352655953339914 no 2149 0.36023707997964 707 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_529 4076-0302 30.3 µM -0.358561809480395 0.352374862531101 no 2150 0.359961460519277 696 5816522
SGTC_2699 st077704 54.6 µM -0.358658161817474 0.352338102307805 no 2151 0.359925415360736 701 645852
SGTC_780 0109-0199 192 µM -0.360138983899727 0.351773314606206 no 2152 0.359371600528148 737 610414
SGTC_608 k048-0125 159 µM -0.360920165607346 0.351475502415542 no 2153 0.359079564131511 728 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_3165 9101544 49.47 µM -0.361403426545994 0.351291313054833 no 2154 0.35889894342466 715 5002184
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.362570566686754 0.350846615070254 no 2155 0.358462850288304 711 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1243 0416-0003 5.65 µM -0.364732284404573 0.350023507880693 no 2156 0.357655628434264 716 2141977
SGTC_1250 0485-0349 40.2 µM -0.365046841541089 0.349903794021365 no 2157 0.357538220439871 718 6842794 YDL195W SEC31
SGTC_2279 7948423 32.93 µM -0.365333618846515 0.349794665584114 no 2158 0.357431192974527 681 1247112
SGTC_1320 1313-0481 95.3 µM -0.365441226065636 0.349753720608771 no 2159 0.357391036036833 725 6813365 YLR208W SEC13
SGTC_88 0180-0332 8.668 µM -0.366056342607126 0.349519699872123 no 2160 0.357161516738462 685 3101745
SGTC_1416 3966-0321 25.3 µM -0.366662225968408 0.349289247790609 no 2161 0.356935493145972 713 582530 YLR208W SEC13
SGTC_2248 tofa 1.1 µM -0.367810661990319 0.34885258441505 no 2162 0.356507209186991 704 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_43 0570-0105 72.5 µM -0.36877239928351 0.348487062376002 no 2163 0.356148689548882 723 1114046 YDL195W SEC31
SGTC_510 ag-490 170 µM -0.370761226687872 0.347731626475197 no 2164 0.355407691437513 718 5328779
SGTC_1770 st043884 66.3 µM -0.371194010716024 0.347567317791133 no 2165 0.355246516863756 717 670149
SGTC_202 3594-0513 34.79 µM -0.371621533112508 0.347405034824812 no 2166 0.355087327211938 698 708429
SGTC_1670 st016595 4.04 µM -0.371673706271034 0.347385232361521 no 2167 0.355067902061355 714 597879
SGTC_751 0833-0568 350 µM -0.372155725964669 0.347202300192588 no 2168 0.354888453939432 727 6954252
SGTC_104 0074-0074 590.992 µM -0.373242995438792 0.346789799331324 no 2169 0.354483799373182 715 3943124
SGTC_2849 9019321 12.99 µM -0.373384440601948 0.346736149565193 no 2170 0.354431169073026 676 16489627
SGTC_829 1635-0120 117 µM -0.375241882377211 0.346031912466179 no 2171 0.353740292213226 721 285054
SGTC_2619 obliquin 87.91 µM -0.376376348835461 0.345602048425725 no 2172 0.353318563219148 702 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2158 5657123 3.6195 µM -0.376921690950119 0.345395482023113 no 2173 0.353115900615541 760 2858827
SGTC_3344 9148862 3.898 µM -0.377135134356455 0.345314645790606 no 2174 0.353036591111154 746 4905352
SGTC_1687 st020778 55.3625 µM -0.378084277561603 0.34495526756536 no 2175 0.352683993823357 701 4259299
SGTC_1267 0828-0272 9.49 µM -0.378484448319509 0.34480379105087 no 2176 0.352535372252509 711 745334
SGTC_3226 9131256 49.47 µM -0.378718834517942 0.344715080464641 no 2177 0.352448332752478 689 17178073
SGTC_330 1488-0319 80.1 µM -0.378779319871292 0.344692189328555 no 2178 0.352425872722652 697 6846614
SGTC_866 0495-0101 262 µM -0.380689913928927 0.343969403717047 no 2179 0.351716676927901 700 635694
SGTC_488 nitrendipine 139 µM -0.382012497375527 0.34346939848876 no 2180 0.351226047412018 709 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1058 3448-5425 97.3 µM -0.383529198487516 0.342896343742106 no 2181 0.350663712524213 733 7279705
SGTC_3028 9087778 49.47 µM -0.384367888787365 0.342579616640719 no 2182 0.350352898510094 684 17217395
SGTC_2305 7443522 69.23 µM -0.384431667253522 0.342555535553594 no 2183 0.350329266657592 698 5415886
SGTC_571 k831-0106 44.2 µM -0.384665014655267 0.342467435108715 no 2184 0.350242809319645 740 4783639
SGTC_1238 0333-0287 48.8 µM -0.384725534510745 0.342444587202145 no 2185 0.350220387429048 712 7226
SGTC_664 1222-0054 14.9 µM -0.38474112045557 0.342438703173535 no 2186 0.350214613105382 711 6813991
SGTC_164 4100-3994 89.624 µM -0.385075530707956 0.342312465342085 no 2187 0.350090728219711 734 4615967
SGTC_684 1140-0066 328 µM -0.385500487928021 0.342152072001666 no 2188 0.349933322521015 727 6813534
SGTC_1611 st001856 99.4 µM -0.385829383368917 0.342027955196505 no 2189 0.34981151615341 740 647478
SGTC_2774 tamoxifen 10.92 µM -0.387154850128456 0.341527930742923 no 2190 0.349320786548088 708 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2868 9035608 32.47 µM -0.389484784756108 0.340649651011012 no 2191 0.348458781933701 699 6462614
SGTC_1900 st060200 72.8 µM -0.389602161547181 0.340605428082954 no 2192 0.348415376761706 693 688945
SGTC_3105 9121040 49.47 µM -0.390232176796513 0.340368100733825 no 2193 0.348182435161852 687 41448907
SGTC_568 1193-0097 7.48 µM -0.390817959031427 0.340147492707307 no 2194 0.347965899631149 712 3646150
SGTC_595 3909-8003 73.7 µM -0.391379932118625 0.339935902722438 no 2195 0.347758211782625 736 699517
SGTC_2726 cimetidine 79.27 µM -0.391558453119858 0.339868697852087 no 2196 0.347692245506109 721 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1550 gossypolone 36.6 µM -0.39213706252257 0.339650913255957 no 2197 0.347478472065485 714 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3101 9120531 49.47 µM -0.394188388550298 0.338879239933893 no 2198 0.346720978865819 771 24824904
SGTC_1698 5-fluorocytosine 1.055 µM -0.394262234361941 0.338851472999138 no 2199 0.346693721222747 715 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2055 5235184 200 µM -0.394770227678636 0.338660484991738 no 2200 0.346506234464389 768 2836034
SGTC_1113 artemisinin 1.17947 µM -0.395427457057209 0.338413450913678 no 2201 0.34626372445344 720 2240 An anti-malaria and mitochondrial poison.
SGTC_2848 9016370 25.97 µM -0.396269384709644 0.338097095525803 no 2202 0.345953155005009 698 7894410
SGTC_446 go6976 132 µM -0.397284637371381 0.337715765060335 no 2203 0.345578787398164 727 3501 A protein kinase C inhibitor.
SGTC_270 tamoxifen 5.46 µM -0.397815976352382 0.337516259679891 no 2204 0.345382919874015 709 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1903 st060211 78.3 µM -0.398471356232862 0.337270242737455 no 2205 0.345141384171191 710 688960
SGTC_1128 3448-9350 235 µM -0.398483507977014 0.337265681864071 no 2206 0.345136906325555 685 619386
SGTC_2948 9070189 9.45 µM -0.399926018940362 0.336724439141006 no 2207 0.344605503807991 734 6473636 YDL196W YDL196W
SGTC_3254 9136651 49.47 µM -0.400855402244045 0.336375905360715 no 2208 0.344263293211116 747 16454030
SGTC_2912 7964298 10.93 µM -0.400874969519286 0.336368568825661 no 2209 0.34425608966401 721 2975850
SGTC_2288 7946289 167.31 µM -0.403075082998173 0.335544058355812 no 2210 0.343446495122618 745 1246052
SGTC_891 0929-0073 133 µM -0.40321389620406 0.335492063471703 no 2211 0.34339543887532 733 5603632
SGTC_489 paxilline 115 µM -0.403505402090539 0.335382885161635 no 2212 0.343288230737324 744 105008 A toxic potassium channel blocker.
SGTC_1897 st060201 15 µM -0.407148978241634 0.334019424263601 no 2213 0.34194928626355 713 611878
SGTC_1048 3161-0300 24.5 µM -0.408830367829484 0.333390968902661 no 2214 0.341332076186072 694 2165101
SGTC_3356 9151811 4.48 µM -0.409334596749931 0.333202593563245 no 2215 0.341147064758931 731 1859254 YPR165W RHO1
SGTC_1431 4049-0260 9.09 µM -0.409492526169805 0.333143601217843 no 2216 0.341089125224477 735 3854841
SGTC_1117 retinoic acid 1.10837 µM -0.409679232097969 0.333073865131868 no 2217 0.341020633291485 744 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2988 9073640 71.4286 µM -0.409694721850689 0.333068079850527 no 2218 0.341014951205321 750 9102229
SGTC_3354 9151612 71.43 µM -0.411040570827936 0.332565569349003 no 2219 0.34052139294651 731 27261949
SGTC_3248 9135562 49.47 µM -0.411692097474377 0.332322411553985 no 2220 0.340282558978134 715 17650701
SGTC_1703 st026983 48.3 µM -0.411771392735739 0.332292822397146 no 2221 0.34025349561673 729 1104023
SGTC_565 1418-0001 44.5 µM -0.412257160859244 0.332111580047355 no 2222 0.3400754722217 752 2862145
SGTC_2491 paeonol 100 µM -0.412388217988458 0.332062688746255 no 2223 0.340027448754324 740 11092 Increases levels of cortical cytochrome oxidase.
SGTC_183 3914-0051 30.55 µM -0.414188897774558 0.331391228908871 no 2224 0.339367885968183 736 1596232
SGTC_852 0418-0143 439 µM -0.414542155847866 0.331259565134943 no 2225 0.339238550320757 733 5369229
SGTC_1844 rapamycin 4 nM -0.414996779785785 0.331090151708771 no 2226 0.339072130244601 741 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1515 3460-0031 42.1 µM -0.415012288968386 0.331084372896052 no 2227 0.339066453491914 732 2876596
SGTC_525 k781-2675 26.7 µM -0.417279262400518 0.330240118649192 no 2228 0.338237077527853 703 3651118 YDL195W SEC31
SGTC_1700 st030840 7.9285 µM -0.418679388735598 0.329719122063524 no 2229 0.337725230507532 719 5499307
SGTC_53 0973-0023 39.979 µM -0.419532749980567 0.329401742413564 no 2230 0.337413412580484 744 674768
SGTC_1345 1488-0192 31.4 µM -0.419617459817708 0.329370244075633 no 2231 0.337382465719614 749 658348
SGTC_3084 9116877 49.47 µM -0.420334208954406 0.329103777982414 no 2232 0.337120661361851 746 27241325
SGTC_2739 tacrine 100.86 µM -0.420359535986227 0.329094363729513 no 2233 0.337111411690725 727 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1729 st035615 45.989 µM -0.421053539510548 0.328836439466512 no 2234 0.336857993388071 713 17385451
SGTC_1786 berberine 21.6 µM -0.421294964126036 0.328746733854519 no 2235 0.336769853528798 726 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_115 0527-0192 112.043 µM -0.422825786206405 0.328178159466876 no 2236 0.336211186252319 750 4233931
SGTC_1270 0831-1170 17.3 µM -0.425316692660663 0.327253843532766 no 2237 0.335302913239996 743 6764716
SGTC_604 1000-0114 314 µM -0.425849009248052 0.327056450607652 no 2238 0.335108936262943 752 1572745
SGTC_1322 1348-1070 12 µM -0.426219974432638 0.326918918390643 no 2239 0.334973781977082 737 6758089
SGTC_1936 st074407 74.3 µM -0.426555193228218 0.326794659064013 no 2240 0.334851669603355 714 809813
SGTC_108 0509-0257 621.132 µM -0.426924985137256 0.326657606412551 no 2241 0.334716983306189 716 536624
SGTC_3043 9092303 49.47 µM -0.428674853653441 0.326009385835632 no 2242 0.33407993154659 725 25236084
SGTC_1230 0170-0365 3.77 µM -0.430934679729978 0.325173034396195 no 2243 0.333257933222196 717 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1150 3909-7983 10.9 µM -0.431076553272906 0.32512055695226 no 2244 0.333206354219588 725 23965914
SGTC_3242 9133940 49.47 µM -0.4317085103057 0.324886845230913 no 2245 0.332976640668941 754 17248444
SGTC_309 k408-0051 1.48 µM -0.43254740962024 0.324576708117726 no 2246 0.332671801339583 738 3640463
SGTC_3233 9132340 49.47 µM -0.434533156557411 0.323843071763258 no 2247 0.331950661437109 778 17682950
SGTC_1178 0988-0033 191 µM -0.436329890891116 0.323179855467221 no 2248 0.331298698908425 712 5392207
SGTC_1337 1486-1011 40.3 µM -0.437866639866134 0.322613051276875 no 2249 0.330741479903514 725 X1337
SGTC_789 1309-1135 70.6 µM -0.438155165750903 0.322506679218965 no 2250 0.330636903337491 719 3092424
SGTC_314 1671-0008 2.74 µM -0.438939134755373 0.322217723437297 no 2251 0.330352819576125 770 3913060
SGTC_996 3970-0799 1.8 µM -0.439559479394425 0.321989152536504 no 2252 0.330128096994703 709 6615648 YGL040C HEM2
SGTC_1938 st074717 56.4 µM -0.440623215044659 0.321597367438968 no 2253 0.329742896708918 718 17250979
SGTC_174 3553-0389 74.3 µM -0.440915698897306 0.321489677286766 no 2254 0.329637013988827 712 738071
SGTC_3125 9127534 49.47 µM -0.44125435839538 0.321365004382188 no 2255 0.32951443218005 734 1639235
SGTC_303 1348-1668 34.2 µM -0.441770609674909 0.321174992193361 no 2256 0.329327604173257 741 5380509
SGTC_2003 4023581 200 µM -0.442504677541818 0.320904890720155 no 2257 0.329062023118028 721 16641307
SGTC_122 0236-0016 402.397 µM -0.442509789679871 0.320903010032682 no 2258 0.329060173881506 757 6808838
SGTC_273 hydroxyurea 18.1 mM -0.442611803952982 0.320865481301783 no 2259 0.329023272677738 741 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_24 0417-1663 219 µM -0.443423141792965 0.320567073753966 no 2260 0.328729850120897 752 4329390
SGTC_1935 st074532 41.6 µM -0.444260245759368 0.320259311021394 no 2261 0.328427219800871 742 2829742
SGTC_820 1582-0060 59.9 µM -0.44606663486432 0.319595610259213 no 2262 0.327774556566518 746 3848840
SGTC_2225 6654152 15.4 µM -0.447980000773013 0.318893233874196 no 2263 0.327083815074055 752 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_772 k072-0172 35.3 µM -0.448657161337454 0.31864481096946 no 2264 0.326839495990178 712 5861980
SGTC_1369 1866-0067 208 µM -0.448838129730295 0.318578434757881 no 2265 0.326774215277239 744 3531355
SGTC_2245 6637752 200 µM -0.449570711392304 0.318309795428598 no 2266 0.326510005351116 722 681890
SGTC_2580 diallyl disulphide 81.36 µM -0.449927433604468 0.318179019169703 no 2267 0.32638138285722 698 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1594 piperine 70.1 µM -0.450605525994188 0.317930489388089 no 2268 0.326136941594255 745 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3118 9124250 49.47 µM -0.450768100225434 0.317870915973453 no 2269 0.326078347326653 745 1504786
SGTC_989 1501-0895 10.3 µM -0.455623051927231 0.316094053873319 no 2270 0.324330531822447 762 2830112
SGTC_103 0844-0104 51.839 µM -0.456774840238693 0.315673131924178 no 2271 0.323916445793852 747 5375804
SGTC_210 3551-0445 56.827 µM -0.457144871758757 0.315537954308439 no 2272 0.323783459841842 767 2865180 YOR207C RET1
SGTC_1115 galangin 695.678 nM -0.459927552554023 0.314522194319122 no 2273 0.322784111368548 770 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1889 st059080 5.18 µM -0.460536318640406 0.314300163559039 no 2274 0.322565654447665 745 176925 Isolated from Daphnopsis sellowiana.
SGTC_1961 st076550 68.7 µM -0.461522319354679 0.313940689324883 no 2275 0.322211956074251 746 1579337
SGTC_742 0kpi-0133 140 µM -0.463991941629417 0.313041094444725 no 2276 0.321326759552442 755 2728852
SGTC_925 2064-1272 59.6 µM -0.464635534849037 0.312806838914837 no 2277 0.321096240224888 742 6815817
SGTC_3309 9129340 25.759 µM -0.465016132943403 0.31266834409724 no 2278 0.320959951735842 727 17158987
SGTC_2691 st077356 60.2 µM -0.466979188258179 0.31195443348244 no 2279 0.320257384009737 750 2839272
SGTC_1299 1079-1439 3.74 µM -0.467356614468817 0.311817254501269 no 2280 0.320122378766133 768 323161
SGTC_2327 6189656 200 µM -0.470266355873703 0.310760560099027 no 2281 0.319082365675548 765 5349088
SGTC_2884 9058502 51.95 µM -0.471238669275427 0.310407804272373 no 2282 0.318735153637378 755 6471554
SGTC_2549 cedrol 20.94 µM -0.471728913188894 0.310230009596866 no 2283 0.31856014837816 754 6708665 A sedative which affects the nervous system.
SGTC_2400 5203494 178.7 µM -0.472025949550631 0.310122306254497 no 2284 0.318454133242812 754 6777674
SGTC_2605 digitonin 300 nM -0.472731407260303 0.309866577428692 no 2285 0.31820240818071 768 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_18 0111-0177 500 nM -0.473367490183568 0.309636075848179 no 2286 0.31797550974432 766 721752
SGTC_2651 TUB2.036 5 µM -0.47343402798804 0.309611968426219 no 2287 0.317951778853686 740 15992207 YFL037W TUB2
SGTC_1559 coumarin 343 70.1 µM -0.473960670869972 0.309421188476752 no 2288 0.317763976604378 771 108770 A hepatotoxic, DNA x-linker.
SGTC_2274 7947094 46.08 µM -0.47543539433452 0.308887233290549 no 2289 0.317238335822604 724 2971028
SGTC_2053 5265679 138 µM -0.476715076751346 0.308424223916858 no 2290 0.316782512714535 746 764595
SGTC_3117 9124945 49.47 µM -0.477401929131503 0.308175835385106 no 2291 0.316537970381033 745 17592065
SGTC_1449 4112-4002 201 µM -0.478404316084296 0.307813496738564 no 2292 0.316181231130332 728 2059539
SGTC_3011 9081274 71.4286 µM -0.480251404661496 0.307146309698293 no 2293 0.315524319375052 747 6625322
SGTC_59 0330-0160 1.33 µM -0.480357801727351 0.307107897415678 no 2294 0.315486497289325 774 4293482
SGTC_116 0155-0182 31.788 µM -0.481542984057214 0.306680157017124 no 2295 0.315065318808755 748 771486
SGTC_2257 7960413 200 µM -0.482450132405697 0.306352938729772 no 2296 0.314743107652414 742 2974689 YIL048W NEO1
SGTC_336 4111-0029 111 µM -0.482541147312135 0.30632011717899 no 2297 0.314710787732834 755 3131175
SGTC_408 cantharidin 100 µM -0.48387536411083 0.30583915398799 no 2298 0.314237162655897 726 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2009 4012297 12.05 µM -0.484055318977291 0.305774308817231 no 2299 0.314173305010364 764 45595307
SGTC_1743 st037606 46.3785 µM -0.48426050080396 0.305700380760342 no 2300 0.314100502271957 709 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_864 0469-0573 172 µM -0.487560605329098 0.304512425874396 no 2301 0.312930552603323 771 689425
SGTC_913 3487-1245 167 µM -0.48785560885457 0.304406332086332 no 2302 0.31282605969855 731 4016153
SGTC_2985 9022375 71.43 µM -0.487931836849489 0.304378920456273 no 2303 0.312799061500988 780 4939335
SGTC_2207 7258803 200 µM -0.488759715945149 0.304081285470143 no 2304 0.312505910519823 781 3666799
SGTC_2339 9000433 200 µM -0.489529427708609 0.303804678934545 no 2305 0.312233462905791 726 2988954
SGTC_2385 9074692 200 µM -0.489905924876205 0.303669420381879 no 2306 0.312100235127073 739 17046906
SGTC_518 1021-0119 62.6 µM -0.4902478237417 0.303546614741443 no 2307 0.311979271636395 773 1097762
SGTC_1833 st055984 71 µM -0.49132697148451 0.303159144421877 no 2308 0.311597603233378 730 676288
SGTC_2811 7967822 32.47 µM -0.491784177829709 0.302995050235174 no 2309 0.311435961424826 732 2232244
SGTC_736 0958-0254 92.6 µM -0.493619898793457 0.302336599177991 no 2310 0.310787322445118 782 6812352
SGTC_553 k007-0256 45.7 µM -0.494499255250964 0.30202141213398 no 2311 0.310476816095359 760 6287000
SGTC_1461 k072-0203 53.8 µM -0.494597730391218 0.301986124956917 no 2312 0.310442052299592 759 5418714
SGTC_1375 2910-0797 186 µM -0.495076797572288 0.301814484416969 no 2313 0.31027295566717 772 742508
SGTC_2313 7726885 200 µM -0.495951959375594 0.301501044076992 no 2314 0.309964152837852 743 726423
SGTC_2445 5742597 35.57 µM -0.497258800826208 0.301033269989001 no 2315 0.309503280371158 734 1774255
SGTC_3277 9138724 49.47 µM -0.500758288309508 0.299782268668453 no 2316 0.308270622333193 762 15943418
SGTC_3096 9117468 49.47 µM -0.501329705260702 0.29957822158015 no 2317 0.308069551335372 769 41316311
SGTC_900 1112-0045 141 µM -0.501831536477534 0.299399074764182 no 2318 0.307893013760761 752 56211 YIL048W NEO1
SGTC_1669 st015249 58.4 µM -0.503217905935013 0.298904412679045 no 2319 0.307405538487669 771 722793
SGTC_1039 k821-0043 94 µM -0.503929511316527 0.298650653352003 no 2320 0.307155455771115 761 15992768
SGTC_1123 mangostin 811.285 nM -0.50439942884808 0.298483133921221 no 2321 0.306990359664608 735 5281650 An antioxidant.
SGTC_3075 9116269 49.47 µM -0.505578633741941 0.298062951222733 no 2322 0.306576242005435 780 17015205 YNL244C SUI1
SGTC_2810 7959871 45.46 µM -0.505778940610972 0.297991603239307 no 2323 0.306505921989257 751 2974535
SGTC_2862 9027634 71.43 µM -0.505785749557132 0.297989178074474 no 2324 0.306503531756053 748 5012562
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.506245895326525 0.29782530728721 no 2325 0.306342019862665 803 688798
SGTC_1266 0828-0227 32.9 µM -0.506385729123963 0.297775516701836 no 2326 0.306292945430391 754 3913820
SGTC_2283 7944793 200 µM -0.508145296632006 0.297149312701268 no 2327 0.305675725417981 748 2970533
SGTC_2246 7293507 91.5585 µM -0.50945997113642 0.296681832846486 no 2328 0.305214924665619 774 887656
SGTC_745 0469-0705 296 µM -0.510631221038842 0.296265636678338 no 2329 0.304804654895305 775 3486736
SGTC_1075 aripiprazole 15.2 µM -0.511169339938029 0.296074509381825 no 2330 0.304616242821231 751 60795 An atypical antipschotic. YIL048W NEO1
SGTC_733 4069-0007 56.1 µM -0.511785642209594 0.295855682716382 no 2331 0.304400519991726 761 5717425 YNL287W SEC21
SGTC_258 haloperidol 50.781 µM -0.512338214025576 0.295659547614591 no 2332 0.304207162424079 772 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1771 st048882 4.1505 µM -0.514890493195722 0.294754393838452 no 2333 0.303314772255175 756 4580403
SGTC_333 3486-0131 40.1 µM -0.515060158612405 0.294694268117732 no 2334 0.303255491185023 767 6744690
SGTC_456 gingerol 170 µM -0.515620340298327 0.294495792134732 no 2335 0.303059800584915 796 442793 A herb.
SGTC_1493 4348-0038 111 µM -0.516045825738961 0.294345081137627 no 2336 0.302911201747771 785 800424
SGTC_2593 nobiletin 86.24 µM -0.517529667046046 0.293819769295746 no 2337 0.302393232385546 747 72344 An anti-infammatory.
SGTC_3025 9087895 49.47 µM -0.517545964157957 0.293814002175128 no 2338 0.302387545705078 753 17173641
SGTC_3108 9121785 49.47 µM -0.520947819779368 0.292611322789766 no 2339 0.30120156088534 741 17140271
SGTC_1219 1469-0211 33.1 µM -0.522384866066628 0.292103962861495 no 2340 0.300701195494059 785 6822282
SGTC_694 1315-0438 43.2 µM -0.523338922125378 0.291767352548015 no 2341 0.300369209895347 773 6793154
SGTC_3182 9108849 49.47 µM -0.524794665122521 0.291254085509751 no 2342 0.299862970282244 757 17133045
SGTC_881 0833-0569 170 µM -0.525522290741593 0.290997696765747 no 2343 0.299610080843108 734 5418700
SGTC_3348 9149464 3.537 µM -0.525869001941008 0.290875565482987 no 2344 0.299489613866546 755 1951442
SGTC_2382 9035899 200 µM -0.52631447883599 0.29071867851701 no 2345 0.299334862369789 795 6462679
SGTC_973 1325-0077 65.9 µM -0.526591844722238 0.290621016470443 no 2346 0.299238528253954 764 2835149
SGTC_14 0354-0009 295 µM -0.52665602184927 0.290598421539466 no 2347 0.299216240398012 784 1713507
SGTC_3157 9099274 49.47 µM -0.5267893472379 0.290551484110668 no 2348 0.299169940685841 770 17217662
SGTC_2667 digitoxin 100 µM -0.527982995587826 0.290131416331286 no 2349 0.298755569120011 751 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1004 4084-0029 199 µM -0.528672810933614 0.289888786893785 no 2350 0.298516220724379 738 716894 YLR208W SEC13
SGTC_1646 st011709 75.6 µM -0.529178527546287 0.289710971165537 no 2351 0.29834080534888 777 5757843
SGTC_392 N-ethylmaleimide 8.33 µM -0.529198580946195 0.289703921216663 no 2352 0.298333850494313 746 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1292 0kpi-0043 232 µM -0.531232488395161 0.288989301750471 no 2353 0.297628841077522 791 3333905
SGTC_3106 9121286 49.47 µM -0.531247786080194 0.288983930006702 no 2354 0.297623541352498 756 15943471
SGTC_3271 9137798 49.47 µM -0.53247067506274 0.288554667658426 no 2355 0.297200023504003 763 6498326
SGTC_1441 4106-0040 13 µM -0.534386045090376 0.287882932859 no 2356 0.296537235916089 763 2904180
SGTC_707 0865-0008 204 µM -0.534872656531113 0.287712392247122 no 2357 0.296368958630204 784 723043
SGTC_1861 st057647 17.4 µM -0.535243803809394 0.287582349960674 no 2358 0.296240639961635 773 688668
SGTC_3291 9121177 71.43 µM -0.536844784418528 0.287021718327649 no 2359 0.295687416920668 773 17015612
SGTC_1644 st010134 20.9 µM -0.53698558278364 0.286972438308809 no 2360 0.295638786399506 795 3818134
SGTC_705 1124-0212 310 µM -0.53748306516252 0.286798349494971 no 2361 0.295466989796453 807 9554485
SGTC_205 1486-1330 71.903 µM -0.537855299688715 0.28666812262028 no 2362 0.295338475328354 783 4118834
SGTC_3272 9137413 49.47 µM -0.539418986161578 0.286121370807746 no 2363 0.294798891667 801 17614870
SGTC_168 3970-0862 530.542 µM -0.539558423083472 0.286072639967455 no 2364 0.294750798035784 784 3135186
SGTC_522 1273-0010 11.6 µM -0.540974590500957 0.285577937016487 no 2365 0.294262548334281 786 5705015
SGTC_2765 myclobutanil 7.74 µM -0.543941636902838 0.28454279515045 no 2366 0.293240817806183 813 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2467 5474540 200 µM -0.544259398018893 0.284432041110659 no 2367 0.293131491322295 750 5413519
SGTC_1052 3253-3998 198 µM -0.544325874476905 0.284408873680726 no 2368 0.293108622326453 762 5450317
SGTC_1475 4092-1048 11.7 µM -0.544837208922465 0.284230700817693 no 2369 0.292932742527757 787 2881759
SGTC_397 arbidol 50 µM -0.546430511054753 0.283675862216644 no 2370 0.292385020892896 773 131410 A RNA synthesis inhibitor.
SGTC_1064 honokiol 6.76 µM -0.546821665226307 0.283539729217036 no 2371 0.292250628583442 787 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1884 5633444 25 µM -0.549431584221678 0.282632203894351 no 2372 0.291354651950383 760 5724239
SGTC_654 1124-0271 80.9 µM -0.549679571307633 0.282546046098749 no 2373 0.291269585521245 778 5403748
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.549848493450965 0.282487364953153 no 2374 0.291211647192998 749 6312947
SGTC_1454 4239-0054 42.6 µM -0.550551374210555 0.282243257138322 no 2375 0.290970625069083 792 1340767
SGTC_3034 9090421 49.47 µM -0.5507589424927 0.282171188884147 no 2376 0.290899466463296 771 17173761
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.550798184659976 0.282157564896036 no 2377 0.290886014368805 779 688667
SGTC_2602 kawain 100 µM -0.552110861119067 0.281702016034097 no 2378 0.290436200531687 774 5369129
SGTC_2186 6124449 200 µM -0.552684860378876 0.281502927856945 no 2379 0.290239611018434 760 3834182 YLR033W RSC58
SGTC_1695 st026914 34.495 µM -0.553202313120636 0.281323510695364 no 2380 0.290062441615306 775 3289191
SGTC_34 0469-0683 81.75 µM -0.553350595944198 0.281272106547881 no 2381 0.290011680761214 762 3690923
SGTC_3323 9138564 53.9225 µM -0.553841085046458 0.281102104509194 no 2382 0.289843803966816 760 43912313 YNL103W MET4
SGTC_363 0455-0021 3.06 µM -0.554043543594042 0.281031947464151 no 2383 0.289774522974729 778 4597466
SGTC_1188 1403-0014 4.57 µM -0.554462175989915 0.280886907511385 no 2384 0.289631292285265 771 9614867
SGTC_2194 5927483 104.545 µM -0.554846116370372 0.28075391882092 no 2385 0.289499960329312 743 760979
SGTC_299 1273-0059 1.44 µM -0.555089055509294 0.280669785660613 no 2386 0.289416874188623 776 2848077
SGTC_2662 daunorubicin 22.37 µM -0.555785875855996 0.280428534887633 no 2387 0.289178621056463 759 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_182 3448-4371 550.524 µM -0.556259755531596 0.280264527247851 no 2388 0.2890166473178 739 3491403
SGTC_2935 9038016 29.96 µM -0.55682341118865 0.280069509060864 no 2389 0.288824043423544 781 6463195
SGTC_2479 5617353 43.85 µM -0.557020289613125 0.280001406958348 no 2390 0.288756783343556 803 2731746
SGTC_2747 doxorubicin 7.63 µM -0.557870253618023 0.279707488578693 no 2391 0.288466492644328 749 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2963 9082507 9 µM -0.557937159336035 0.279684358874229 no 2392 0.288443647978929 800 16459611
SGTC_1932 st074806 40.9 µM -0.558013634647513 0.279657922041315 no 2393 0.288417536862048 793 17251235
SGTC_1530 rhein 70.4 µM -0.558799342157021 0.279386380227791 no 2394 0.288149335742856 782 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_541 4513-1321 94 µM -0.559661611536284 0.279088525990982 no 2395 0.287855135742559 777 747515
SGTC_274 sirtinol 40.1 µM -0.561033739671097 0.278614869510995 no 2396 0.287387268376054 760 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2191 5911152 200 µM -0.562087048956263 0.278251534596664 no 2397 0.287028355891186 771 2875902
SGTC_490 phenamil 164 µM -0.562118067760831 0.278240838284144 no 2398 0.287017789530409 787 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_813 k007-0158 173 µM -0.562639969570021 0.278060899301947 no 2399 0.286840034593294 793 6523916
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.563465970673786 0.277776230396272 no 2400 0.286558812919346 806 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2215 7188065 200 µM -0.56397725276123 0.277600096019014 no 2401 0.286384806550742 790 940217
SGTC_3054 9094397 49.47 µM -0.567152230993911 0.276507553470671 no 2402 0.285305379686552 802 2598354
SGTC_2676 harmalol 100 µM -0.567241324921737 0.276476925772579 no 2403 0.285275117572884 771 5459187 A monoamine oxidase inhibitor
SGTC_605 1315-0399 119 µM -0.569605170220116 0.275664918024001 no 2404 0.2844727604888 784 24020461
SGTC_1023 4482-3888 16 µM -0.570608073520346 0.275320763914238 no 2405 0.284132672276761 791 3303168
SGTC_779 1360-0071 233 µM -0.571496348898471 0.275016121962211 no 2406 0.283831617287663 792 7566
SGTC_176 1486-1328 72.834 µM -0.572313336299531 0.274736075537264 no 2407 0.283554858161471 768 22310231
SGTC_828 2074-0507 139 µM -0.572390805451047 0.274709528010736 no 2408 0.283528621759563 786 X828
SGTC_286 k060-0067 22.9 µM -0.572906498080486 0.27453284005648 no 2409 0.283354002293132 770 5985051
SGTC_2951 9072950 58.06 µM -0.573909443231561 0.274189369014544 no 2410 0.283014541250947 802 16488155
SGTC_3021 9087658 49.47 µM -0.575955057508109 0.273489481548777 no 2411 0.282322779775931 780 25237042
SGTC_105 0111-0055 734.78 µM -0.576670815455381 0.273244800792399 no 2412 0.282080925543464 784 5179370
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.578058494225534 0.272770734077189 no 2413 0.281612314017834 784 641818 YHR062C RPP1
SGTC_418 lividomycin a 100 µM -0.578124575041306 0.272748169355404 no 2414 0.281590008255855 772 72394 An antibiotic.
SGTC_2151 5563267 85.4165 µM -0.57854574852757 0.272604372338506 no 2415 0.281447860007944 807 5310824
SGTC_544 k015-0020 52.4 µM -0.579140549010815 0.272401359727254 no 2416 0.281247170738526 800 3008304
SGTC_3260 9137109 49.47 µM -0.579725378453686 0.272201823596214 no 2417 0.281049913149789 788 17478346
SGTC_1506 4226-2149 212 µM -0.580470217858621 0.271947799385947 no 2418 0.2807987824914 790 991114
SGTC_567 1080-0542 68.4 µM -0.580901525755838 0.271800757648417 no 2419 0.280653411994508 756 5950415
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.5812979479665 0.27166564406169 no 2420 0.280519831688223 796 165521
SGTC_1363 1636-0063 10.4 µM -0.582889147750602 0.27112364810433 no 2421 0.279983963325126 791 6072185
SGTC_1781 st038725 66.3 µM -0.58349214770906 0.270918394680247 no 2422 0.279781020778216 770 4270275 YIL048W NEO1
SGTC_2819 7996655 46.38 µM -0.585054108320694 0.270387084201354 no 2423 0.279255667488409 781 6456960
SGTC_2127 5253358 187.912 µM -0.58517154550046 0.270347158284871 no 2424 0.279216187792717 786 20612
SGTC_3217 9129673 49.47 µM -0.585523327743035 0.270227578122613 no 2425 0.279097942879678 797 17248312
SGTC_169 k015-0017 16.025 µM -0.585576359848721 0.270209553390632 no 2426 0.279080119257704 844 1840002
SGTC_1948 st076329 66.6 µM -0.586457472810351 0.269910165738729 no 2427 0.278784065997889 797 24208413
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.58928083692199 0.268951953007339 no 2428 0.277836448840622 772 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1154 4088-0362 150 µM -0.591684780021612 0.268137434538551 no 2429 0.277030845117662 797 6618304
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.592947809469723 0.267709985342632 no 2430 0.276608040335251 804 5355888
SGTC_791 1348-1292 225 µM -0.593140383566987 0.26764484234745 no 2431 0.2765436030895 803 5437054
SGTC_3294 9122953 26.2835 µM -0.5937799113659 0.267428563447301 no 2432 0.276329663416742 795 16459826
SGTC_560 2332-1943 155 µM -0.594337397639049 0.267240101724513 no 2433 0.276143235157377 810 21177716
SGTC_10 0279-0212 42.575 µM -0.595390815316312 0.266884170365009 no 2434 0.275791131760923 791 39851 YBR002C RER2
SGTC_982 1491-0518 27.5 µM -0.598578622836353 0.26580852711002 no 2435 0.274726957454234 801 3091256
SGTC_1273 0849-0096 14.1 µM -0.598823525468213 0.26572598202789 no 2436 0.274645286314905 808 5286025
SGTC_353 1988-1175 58.3 µM -0.599362054975193 0.265544514948271 no 2437 0.27446573740251 800 2788357
SGTC_2318 6029776 164 µM -0.599742269211989 0.26541643287936 no 2438 0.274339006629302 820 818325
SGTC_3287 9117173 37.0625 µM -0.600199914207806 0.26526230844097 no 2439 0.274186505413115 776 2789709
SGTC_1362 1611-0397 101 µM -0.600423946187137 0.26518687612894 no 2440 0.274111866420099 804 27816
SGTC_2290 7904846 200 µM -0.600667480525334 0.265104889665998 no 2441 0.274030741366139 782 2962154
SGTC_3306 9127676 59.7925 µM -0.601074466011273 0.264967905694527 no 2442 0.27389519469427 786 41905287
SGTC_834 0312-0008 75.7 µM -0.601704954363319 0.26475576573257 no 2443 0.273685275777499 805 6385573 YIL048W NEO1
SGTC_1896 st058441 89 µM -0.602118967738008 0.264616509938778 no 2444 0.273547474760732 773 688759
SGTC_444 curcumin 90.4 µM -0.60335353150009 0.264201478592213 no 2445 0.273136764135919 794 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1079 idarubicin 2.36 µM -0.603383888806189 0.264191277356662 no 2446 0.273126668817604 821 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2890 9046729 58.44 µM -0.604270150746677 0.263893547322944 no 2447 0.272832024047414 805 903329
SGTC_2061 5245884 80.95 µM -0.604785576743836 0.26372047427725 no 2448 0.27266073915145 813 573863
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.605730971645768 0.26340317406703 no 2449 0.272346706998121 801 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_477 mead ethanolamide 10 µM -0.605757325419389 0.263394331817773 no 2450 0.272337955630775 766 16061185
SGTC_2435 5706476 10.6 µM -0.606038886880443 0.263299871443162 no 2451 0.272244465491816 784 5725375
SGTC_468 gf-109203x 121 µM -0.607089807531008 0.262947453467874 no 2452 0.271895656959693 775 2396 A protein kinase C inhibitor.
SGTC_562 3772-2733 112 µM -0.60779973358889 0.262709521891366 no 2453 0.271660153006503 794 2876874 YIL048W NEO1
SGTC_1749 st037932 54.2 µM -0.608016306200933 0.262636959554916 no 2454 0.271588329539082 819 594497
SGTC_2354 9060492 162 µM -0.609013302010782 0.262303049893783 no 2455 0.271257810959433 807 6471895
SGTC_2391 6285546 200 µM -0.609224892722872 0.262232212799196 no 2456 0.271187691367987 803 846083
SGTC_2096 5468907 200 µM -0.611284748609528 0.261543119363986 no 2457 0.270505542998895 790 759785
SGTC_1810 st050138 53 µM -0.611757606851507 0.26138506312663 no 2458 0.270349070850393 833 3444541
SGTC_892 0929-0076 29 µM -0.611979873834616 0.261310785755991 no 2459 0.27027553676293 795 5751038
SGTC_152 4469-0003 551.229 µM -0.612355321153674 0.261185343080827 no 2460 0.270151347707471 793 697280
SGTC_2075 5212009 200 µM -0.614939868908637 0.260322646794436 no 2461 0.269297215979806 818 780898
SGTC_2850 9015429 58.44 µM -0.614958076096947 0.260316574627917 no 2462 0.269291203743207 827 6457570
SGTC_2025 5147754 141 µM -0.616547496671944 0.25978677819681 no 2463 0.268766617174055 783 315777 YLR208W SEC13
SGTC_1402 3909-7673 35.9 µM -0.616913251022365 0.259664941274879 no 2464 0.268645973034051 787 5328014
SGTC_293 4049-0273 38.5 µM -0.617245037935808 0.259554444810437 no 2465 0.26853655660372 800 1380311
SGTC_2295 7971645 200 µM -0.618016998029053 0.259297449516926 no 2466 0.268282066927491 798 2978226 YKL099C UTP11
SGTC_980 1473-0395 201 µM -0.61810554802074 0.259267978511904 no 2467 0.268252882686592 818 768876
SGTC_2914 7968218 45.32 µM -0.61815461322843 0.259251649487422 no 2468 0.268236712499384 784 2977111
SGTC_2695 st077686 51.995 µM -0.619895934094522 0.258672477869864 no 2469 0.267663151401031 786 2876092
SGTC_3179 9107801 49.47 µM -0.620829558476721 0.258362226021792 no 2470 0.26735588636862 781 4818259
SGTC_354 2783-3500 4.88 µM -0.621209439615557 0.258236043284917 no 2471 0.26723091467442 807 6740761
SGTC_1201 1889-3372 45.9 µM -0.621737702192244 0.258060626727418 no 2472 0.267057178097831 797 5392199
SGTC_2893 9048488 25.97 µM -0.622966946119609 0.257652679398187 no 2473 0.266653121570748 808 6467338
SGTC_1499 4480-0877 67.3 µM -0.62409342792566 0.257279129816618 no 2474 0.266283114877146 798 2861909
SGTC_3215 9129942 49.47 µM -0.624736560096881 0.257065988804262 no 2475 0.266071986858904 823 17682944
SGTC_457 grayanotoxin iii 135 µM -0.624817762618546 0.257039083934627 no 2476 0.266045335649846 813 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_139 0099-0334 718.624 µM -0.625963743555368 0.25665954178203 no 2477 0.26566936130884 819 97690
SGTC_2836 9010338 19.48 µM -0.626491342095921 0.256484902400057 no 2478 0.265496356974757 785 2994051
SGTC_3080 9117754 49.47 µM -0.62681906226237 0.256376455554001 no 2479 0.26538892335287 818 9550191
SGTC_2514 salinomycin 42.74 µM -0.628628245303279 0.255778203824892 no 2480 0.264796232132853 808 23682228 A polyether potassium ionophore.
SGTC_1401 3807-4679 7.6 µM -0.629181644043559 0.255595354317564 no 2481 0.264615072329104 819 3291456
SGTC_1249 0481-0015 10.2 µM -0.62932850583504 0.255546840905699 no 2482 0.264567006455246 839 4227577
SGTC_1968 st069590 43.6 µM -0.629898159230065 0.255358710665773 no 2483 0.264380608658648 815 6384066
SGTC_7 0192-1582 4.227 µM -0.630630335575698 0.255117012947056 no 2484 0.264141129513404 837 252616
SGTC_1124 fisetin 1.16336 µM -0.631124957770761 0.25495380164291 no 2485 0.263979411786815 816 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1830 st055982 50.3 µM -0.631492251620284 0.254832640442717 no 2486 0.263859356976177 843 455313 An antimicrobial agent.
SGTC_154 3389-1638 511.116 µM -0.631655243870534 0.254778882968075 no 2487 0.263806089740766 844 5238686
SGTC_3343 9148379 18.9835 µM -0.633201514321224 0.254269193487407 no 2488 0.263301028480545 804 1955036
SGTC_1574 spiramycin 23.7 µM -0.633937974861704 0.254026625717647 no 2489 0.263060650693113 817 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2497 7-hydroxyflavone 100 µM -0.634193411460179 0.253942521013998 no 2490 0.262977303407251 826 5281894
SGTC_2282 7944268 200 µM -0.635339353485327 0.253565389619031 no 2491 0.262603556234143 817 2970414
SGTC_2700 st077718 96.8 µM -0.635575014982568 0.253487869526788 no 2492 0.262526729322516 807 904970
SGTC_2478 5763493 32.33 µM -0.635696331740688 0.253447967625022 no 2493 0.262487183895089 810 1365576 YLR208W SEC13
SGTC_766 1391-0721 126 µM -0.635932582765833 0.253370272539679 no 2494 0.262410182282913 831 1020919 YIL115C NUP159
SGTC_770 0389-1121 67.2 µM -0.635958614845935 0.253361712222267 no 2495 0.262401698319773 807 6753108
SGTC_106 0092-0003 11.579 µM -0.635999481213782 0.253348274145255 no 2496 0.262388380083895 804 1072148
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.640410336779744 0.251900059051382 no 2497 0.260952932206898 804 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_817 1391-0715 46 µM -0.64514658224665 0.250349887279407 no 2498 0.259416099567895 835 1353946
SGTC_1343 1487-0095 224 µM -0.646102452075284 0.250037645797473 no 2499 0.259106503736456 834 4560101 YGL055W OLE1
SGTC_911 3456-4043 236 µM -0.646334993451661 0.249961715810634 no 2500 0.259031215016759 814 914281
SGTC_3019 9081971 49.47 µM -0.649453998043976 0.24894447455476 no 2501 0.258022485633197 817 16451803
SGTC_148 3253-0744 288.01 µM -0.650403642227624 0.248635192919827 no 2502 0.257715762626995 813 6893655
SGTC_1732 st034308 51.822 µM -0.650662060736437 0.248551066205754 no 2503 0.257632329505759 812 830119
SGTC_857 0438-0306 1.35 µM -0.652952328572842 0.247806145453162 no 2504 0.256893505987826 808 4686136
SGTC_1638 st008370 60.6 µM -0.653385045932245 0.247665536019106 no 2505 0.256754038493219 801 24207134
SGTC_493 zm226600 134 µM -0.653966604685743 0.24747662842411 no 2506 0.2565666605955 835 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1360 1598-0022 39.8 µM -0.654948162407833 0.247157963981724 no 2507 0.256250564890243 829 761525
SGTC_2268 7933382 153.85 µM -0.655924164057997 0.246841321052621 no 2508 0.255936459854323 807 935025 YOR257W CDC31
SGTC_1705 st027868 56.3335 µM -0.656474824468506 0.246662766886222 no 2509 0.255759330394659 821 292948
SGTC_976 1348-1067 47.6 µM -0.657418315262585 0.246356996525021 no 2510 0.255455989070026 829 5310671 YGL099W LSG1
SGTC_893 0958-0369 48.9 µM -0.658977626267985 0.245852094312049 no 2511 0.254955068039735 822 6819948
SGTC_2541 muurolladie-3-one 83.07 µM -0.659018717838277 0.245838796447715 no 2512 0.254941874528053 831 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_805 3852-0218 479 µM -0.65935540099151 0.245729855141891 no 2513 0.254833787149095 805 6615355
SGTC_673 1082-0474 110 µM -0.659752408936551 0.245601427721515 no 2514 0.254706364172171 831 3098046
SGTC_1456 k015-0012 13 µM -0.659840356462077 0.245572982605592 no 2515 0.254678141202632 831 2989616
SGTC_1364 1653-0028 37.6 µM -0.660241087360469 0.245443395487012 no 2516 0.254549564618607 807 5718652
SGTC_414 piperonyl butoxide 100 µM -0.661915045675538 0.244902473587554 no 2517 0.254012834366008 817 5794 A potent inhibitor of cytochrome P450.
SGTC_1667 st014849 34.6 µM -0.662390724284878 0.244748880215243 no 2518 0.25386042338787 818 5348460
SGTC_2074 5212007 75.395 µM -0.664191857718759 0.244167776772551 no 2519 0.253283762052395 809 758611
SGTC_1581 himbacine 57.9 µM -0.664248284803028 0.244149583610811 no 2520 0.253265707162147 841 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.664451881460696 0.244083946265882 no 2521 0.253200568268353 791 6708630 An antioxidant.
SGTC_796 1234-0020 70.7 µM -0.665148725977505 0.243859363232994 no 2522 0.252977685920399 812 46495034
SGTC_737 1950-0117 57.9 µM -0.670318522350384 0.242196699705706 no 2523 0.251327381026968 819 5393513
SGTC_3061 glucosamine 200 µM -0.67067742812262 0.242081500211363 no 2524 0.251213022603964 809 91431 and experimental redox chemotherapeutic
SGTC_1804 st050076 49.1 µM -0.672493046364386 0.241499189194957 no 2525 0.2506349327324 826 3895976
SGTC_2531 methyl deoxycholate 70.07 µM -0.673012454737739 0.241332742895894 no 2526 0.250469683679193 835 16667744 Haematoxylin.
SGTC_3262 9137218 49.47 µM -0.674074137439892 0.240992716821172 no 2527 0.250132090506796 788 17650664
SGTC_2616 abietic acid 100 µM -0.674790000529911 0.240763593851864 no 2528 0.24990459714002 836 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_194 1486-1323 56.904 µM -0.674846053245826 0.240745658325496 no 2529 0.249886788844564 827 5178754
SGTC_1836 st055642 81 µM -0.675855538050914 0.240422771865621 no 2530 0.249566184599582 839 8571
SGTC_615 k087-0205 167 µM -0.676805343183466 0.240119189604601 no 2531 0.249264733789001 833 9642773
SGTC_2745 rifampicin 24.3 µM -0.677814101954956 0.239796993187049 no 2532 0.248944784302498 798 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2566 crystal violet carbinol 226 nM -0.678061629804552 0.23971796912476 no 2533 0.248866308942533 858 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2997 9067075 71.4286 µM -0.678562071070514 0.239558245058639 no 2534 0.248707691034015 829 27209819
SGTC_959 1222-0044 107 µM -0.678728419102543 0.239505165215229 no 2535 0.248654977936523 822 6083612
SGTC_1653 st012112 65 µM -0.679333941584317 0.239312003835162 no 2536 0.248463147569159 833 720429
SGTC_1278 0874-0585 172 µM -0.680488168993779 0.238944041681171 no 2537 0.24809770526763 820 766306
SGTC_2101 5377231 179.231 µM -0.681636100312058 0.238578393747003 no 2538 0.247734540960153 842 2844213
SGTC_768 0384-0033 77.3 µM -0.682917424147441 0.238170618568105 no 2539 0.247329511539144 826 3965305 YMR134W ERG29
SGTC_3142 9086498 49.47 µM -0.683031966396496 0.238134184649671 no 2540 0.247293321714518 820 25236367
SGTC_606 k015-0008 38.6 µM -0.683678156810343 0.237928699825786 no 2541 0.247089209766925 843 1970475
SGTC_40 0327-0103 19.753 µM -0.684649949423677 0.237619858501272 no 2542 0.246782419715824 823 409036
SGTC_660 4031-1742 102 µM -0.684951360313065 0.237524113087718 no 2543 0.246687307262456 820 6738706
SGTC_674 0498-0004 451 µM -0.685504014393757 0.237348613422995 no 2544 0.246512964154592 827 4231473
SGTC_467 ro 31-8220 72.8 µM -0.685752386240807 0.237269764179975 no 2545 0.246434632996396 833 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2957 9076800 11.52 µM -0.685771704488946 0.237263631925154 no 2546 0.246428540994026 836 16459615
SGTC_2698 st077697 67.5 µM -0.686877617888616 0.236912723378064 no 2547 0.246079926207839 833 3154499
SGTC_2687 chenodiol 100 µM -0.687013814375986 0.236869527699208 no 2548 0.246037011574936 812 5702181 A cholesterol synthesis inhibitor.
SGTC_2263 7948595 193.29 µM -0.687661080639168 0.236664301828617 no 2549 0.245833117051304 822 2971371
SGTC_84 0443-0269 128.823 µM -0.688016843192495 0.236551543427918 no 2550 0.245721087378884 818 6150058
SGTC_1802 st050112 57.9 µM -0.688273529869835 0.236470205338492 no 2551 0.245640273739682 831 4662563
SGTC_886 0866-0150 153 µM -0.688415562660142 0.236425205038278 no 2552 0.245595563153194 831 271463
SGTC_343 4130-2827 29.8 µM -0.688814561283226 0.236298815384776 no 2553 0.245469985530174 816 1118244
SGTC_2324 6149169 200 µM -0.688901776434069 0.236271193446423 no 2554 0.245442540729418 823 2888231
SGTC_1473 k844-0725 134 µM -0.690897465893551 0.235639624067889 no 2555 0.244814989379914 835 54682906
SGTC_2262 9014885 67.46 µM -0.691353807355242 0.235495338083436 no 2556 0.244671612671906 830 6457424
SGTC_882 0843-0131 351 µM -0.692192369546272 0.235230328740021 no 2557 0.244408264976068 830 5425421
SGTC_1132 3456-3614 2.5 µM -0.693017937641486 0.234969586838699 no 2558 0.244149147313998 833 3125502
SGTC_1399 3562-5772 25 µM -0.693473730777749 0.234825700635451 no 2559 0.244006152891354 835 23847490
SGTC_1706 st031321 9.9705 µM -0.693738273655151 0.234742211254052 no 2560 0.243923179483624 827 6103185
SGTC_2763 lisinopril 49.32 µM -0.693864771183663 0.234702294602362 no 2561 0.243883509137454 837 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_940 3232-1287 54.8 µM -0.693967708240631 0.234669815293682 no 2562 0.243851230058927 833 1585493 YIL048W NEO1
SGTC_3231 9132313 49.47 µM -0.694039781103323 0.234647075917408 no 2563 0.24382863076967 831 4905967
SGTC_452 diindolylmethane 8 µM -0.694067499164123 0.234638331044401 no 2564 0.243819939748405 814 3071 Inhibits expression of several cancer promoting factors.
SGTC_1818 st052136 56.3 µM -0.694364733000063 0.234544566977494 no 2565 0.24372675233974 827 674169
SGTC_1138 3761-0006 1.03 µM -0.695817576322539 0.234086557840702 no 2566 0.24327154027256 829 12061087
SGTC_1641 st009299 47.1 µM -0.69735357538332 0.233602872972017 no 2567 0.242790773637497 824 4046054
SGTC_3093 9117344 49.47 µM -0.697679450601702 0.233500326433367 no 2568 0.242688841083019 811 24824913
SGTC_2784 7567673 72.73 µM -0.69813050305429 0.233358430279872 no 2569 0.24254779179077 829 3471247
SGTC_1469 k284-2957 126 µM -0.698421829346225 0.233266807660518 no 2570 0.242456714310119 819 23884841
SGTC_2653 dihydrofissinolide 100 µM -0.700126139362854 0.232731199464099 no 2571 0.241924266449833 839 6857746
SGTC_2634 4'-methoxyflavone 100 µM -0.701264456669396 0.232373845067088 no 2572 0.241568995444676 820 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_141 0443-0274 32.331 µM -0.701911505306945 0.23217085183585 no 2573 0.241367176682838 802 1627241
SGTC_1846 st056244 14.8 µM -0.703341825834096 0.231722479576344 no 2574 0.24092137546576 846 5393182
SGTC_2362 9071156 126 µM -0.704026142172408 0.231508133054236 no 2575 0.240708246772728 858 653133
SGTC_3253 9135987 49.47 µM -0.704285548119974 0.231426908945393 no 2576 0.240627482238363 830 4182430
SGTC_1242 0402-0103 60.1 µM -0.704490818856061 0.231362646692083 no 2577 0.240563582844153 840 432868
SGTC_582 0987-0078 156 µM -0.705969816605987 0.230899924523867 no 2578 0.240103454038848 850 1625765
SGTC_902 1120-0002 2.07 µM -0.70676586055902 0.230651086699364 no 2579 0.239855996726054 825 3280475
SGTC_666 0272-0154 136 µM -0.706885856435173 0.230613589819189 no 2580 0.239818707014976 839 6870312
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.707146416313692 0.230532180562651 no 2581 0.239737746768369 833 688664
SGTC_1474 0330-0125 5.35 µM -0.707395296932884 0.230454435370701 no 2582 0.239660429387976 840 X1474
SGTC_2038 4100038 30.985 µM -0.708056142712533 0.230248071868849 no 2583 0.239455196759382 828 3596803
SGTC_990 3985-0011 41.3 µM -0.708213967228749 0.230198803016062 no 2584 0.239406196891728 833 5399565 YGL099W LSG1
SGTC_916 4466-0038 42 nM -0.708800406096546 0.230015783196668 no 2585 0.239224172868648 849 5722064 YGL116W CDC20
SGTC_720 r052-1644 49.9 µM -0.709603103692698 0.229765403949413 no 2586 0.238975147209658 841 1422863 YOR257W CDC31
SGTC_3252 9135871 49.47 µM -0.711525819667683 0.229166287099129 no 2587 0.238379228360183 854 17682838
SGTC_822 1487-0950 154 µM -0.711807958666635 0.229078446573188 no 2588 0.238291851854032 821 1958375
SGTC_345 1362-0200 395 µM -0.711880949079093 0.229055724976664 no 2589 0.23826925008227 836 1419823
SGTC_2145 5634607 200 µM -0.711931318518161 0.229040045927627 no 2590 0.238253653669791 845 308662
SGTC_2853 9015042 58.44 µM -0.712028736373599 0.229009723309227 no 2591 0.238223490754436 828 6457456
SGTC_2468 5987765 72.9 µM -0.712361912775869 0.228906034696426 no 2592 0.238120347126734 820 26772094
SGTC_2518 prenyletin 46.28 µM -0.713867847091901 0.228437698146728 no 2593 0.237654450491406 814 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1662 st014054 52 µM -0.713936423311394 0.22841638417747 no 2594 0.237633246717985 839 2838777
SGTC_1159 4092-0538 61.2 µM -0.714498498600722 0.228241729360907 no 2595 0.237459492114795 862 717301
SGTC_364 0083-0097 67.7 µM -0.714755156725419 0.228162002424601 no 2596 0.237380174466152 847 5207356
SGTC_1962 st076595 64.5 µM -0.715721025893133 0.227862110265484 no 2597 0.237081812598119 838 279619
SGTC_1135 dihydrocapsaicin 536.708 nM -0.716136693296268 0.227733118229332 no 2598 0.236953474287865 861 107982 A Capsaicinoid.
SGTC_1472 k841-0093 193 µM -0.717683633052905 0.227253425249696 no 2599 0.236476188601378 859 X1472
SGTC_2847 9005661 71.43 µM -0.717909888022055 0.227183313253513 no 2600 0.236406425313032 813 2991449
SGTC_1194 1488-0194 225 µM -0.718079618038605 0.227130725240854 no 2601 0.236354098324546 848 1391452
SGTC_2302 7771753 200 µM -0.718264934404951 0.227073315894944 no 2602 0.236296973418196 840 2203047
SGTC_1264 0783-0040 158 µM -0.721156749853451 0.2261785180498 no 2603 0.235406539210601 840 2855798
SGTC_2502 avocadyne acetate 18.59 µM -0.721613854385693 0.226037261404842 no 2604 0.235265959426488 825 3952079
SGTC_2170 morpholine 200 µM -0.722196163567241 0.225857385663981 no 2605 0.235086940848968 835 121171 Reacts with secondary amines.
SGTC_1324 1418-0026 34.4 µM -0.722725691670542 0.225693884336589 no 2606 0.234924214035456 845 1372513
SGTC_2092 5303694 80.6725 µM -0.723000948939401 0.225608920161293 no 2607 0.23483965060079 835 1963699
SGTC_1495 4469-0029 237 µM -0.723572438816951 0.225432575125318 no 2608 0.234664133511938 830 793680
SGTC_583 1488-1091 88.9 µM -0.723614435018168 0.225419619406333 no 2609 0.234651238418276 864 4303273
SGTC_927 2425-1185 123 µM -0.727527833698353 0.224214197302377 no 2610 0.233451335498639 862 730375
SGTC_55 0767-0285 6.563 µM -0.72862704245206 0.223876273840605 no 2611 0.233114915979382 861 3116166
SGTC_1419 3993-2473 62.6 µM -0.729097853779936 0.223731623589316 no 2612 0.232970903686332 855 704026
SGTC_1009 4106-0057 9.87 µM -0.729549499978418 0.223592911505462 no 2613 0.232832800093451 834 2928005
SGTC_624 k048-0052 28 µM -0.730831231516724 0.2231995254753 no 2614 0.232441122256735 842 6835531
SGTC_3090 9117696 49.47 µM -0.730991330372336 0.223150416006319 no 2615 0.232392224217999 826 7923821
SGTC_1487 3970-0795 2.82 µM -0.73120527425325 0.223084799467589 no 2616 0.232326889547055 840 3765103
SGTC_2807 7945238 51.95 µM -0.732528769644977 0.222679128024287 no 2617 0.231922944719259 856 17148797
SGTC_1030 k029-0042 36.7 µM -0.733115263717881 0.222499493220105 no 2618 0.231744065653316 850 6080581
SGTC_3178 9107506 49.47 µM -0.733295957361498 0.222444165979456 no 2619 0.231688970086655 834 8897194
SGTC_2909 7941780 10.49 µM -0.735573040358472 0.221747610503621 no 2620 0.230995287237568 835 1243215
SGTC_2958 9077254 16.72 µM -0.737796574018727 0.221068639768259 no 2621 0.2303190377528 842 16457351
SGTC_405 ebelactone b 50 µM -0.740106159238145 0.22036465392245 no 2622 0.229617790854672 853 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1637 st007924 17.4 µM -0.740106172241638 0.22036464996247 no 2623 0.229617786909861 838 683336
SGTC_2231 micatex 6.853 µM -0.7404091375388 0.220272398396447 no 2624 0.229525888012101 851 20737 An antifungal of unknown mechanism.
SGTC_134 0269-0018 6.916 µM -0.741811086116791 0.219845799795686 no 2625 0.22910090137757 857 4378915
SGTC_682 0kpi-0099 17 µM -0.74292935384245 0.21950586261601 no 2626 0.228762226438661 861 1714895 YML126C ERG13
SGTC_3012 9080433 71.4286 µM -0.74329762173429 0.219393980639982 no 2627 0.228650755571389 858 17688859
SGTC_1053 3366-3204 134 µM -0.748888783717861 0.217699382107692 no 2628 0.226962120606347 872 3632071 YPR165W RHO1
SGTC_1283 0922-0125 16.4 µM -0.751435450291608 0.216930035235303 no 2629 0.226195317314027 835 3360884
SGTC_3004 9076122 71.4286 µM -0.752779404617393 0.21652466155569 no 2630 0.225791242445226 863 44782551
SGTC_1200 1643-0193 18.4 µM -0.75300539461513 0.216456539813615 no 2631 0.225723336151344 867 5403974
SGTC_2576 guaiol 23.12 µM -0.753035279467495 0.216447532342596 no 2632 0.22571435710755 833 227829
SGTC_73 0327-0325 16.231 µM -0.753693161447287 0.21624929778167 no 2633 0.225516744578805 813 53298
SGTC_778 3456-2434 196 µM -0.754212548480007 0.21609286912542 no 2634 0.225360801924162 815 5539063
SGTC_2044 5102272 200 µM -0.757553526775246 0.215088203326843 no 2635 0.22435915521881 856 592666
SGTC_987 1497-1013 404 µM -0.762144442399503 0.213712101838435 no 2636 0.222986900259356 856 1676435
SGTC_1773 st048542 73.5835 µM -0.763368270006836 0.213346133908114 no 2637 0.222621898774854 858 3237138
SGTC_734 2023-0417 80 µM -0.763917695857339 0.213181954964074 no 2638 0.222458145645701 863 3935732
SGTC_652 0437-0092 114 µM -0.766629868447275 0.212372586325613 no 2639 0.221650805845667 841 3091274
SGTC_1020 4335-0961 93.3 µM -0.767209526483353 0.21219983750781 no 2640 0.221478474873163 884 669075
SGTC_907 3448-6986 75.5 µM -0.768720537620467 0.21174991456948 no 2641 0.221029615061519 874 590582
SGTC_3183 9108214 49.47 µM -0.769123871144777 0.211629911304261 no 2642 0.220909889203924 842 4974831
SGTC_1803 st050068 52.4 µM -0.771660416756788 0.210876129343896 no 2643 0.220157790350601 880 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1797 st048695 56.8 µM -0.773717173592722 0.210266083060777 no 2644 0.219549030973355 872 592262 YIL048W NEO1
SGTC_687 k029-0044 34.9 µM -0.773849861965229 0.210226762520796 no 2645 0.219509791064364 843 5829338
SGTC_651 3253-0966 34.4 µM -0.776642898349805 0.209400083751959 no 2646 0.218684742331234 871 781462
SGTC_2137 5261020 140 µM -0.778620710127877 0.208815852541328 no 2647 0.2181015878423 861 763655
SGTC_679 0422-0091 41.4 µM -0.778655208819656 0.208805670408804 no 2648 0.218091423920876 877 627384 YHR062C RPP1
SGTC_3263 9137018 49.47 µM -0.778695358363781 0.208793820821191 no 2649 0.218079595502723 867 43844957
SGTC_2021 4019055 173 µM -0.779570414703383 0.208535658383053 no 2650 0.217821887879442 871 44827708 YER133W GLC7
SGTC_233 rapamycin 362 pM -0.779841066543928 0.208455847775533 no 2651 0.217742215400478 877 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2214 7179297 48.276 µM -0.78125725347979 0.208038532237207 no 2652 0.217325603030562 852 769744
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.784783779039482 0.207001497114045 no 2653 0.216290176107817 863 5024745
SGTC_3214 9129694 49.47 µM -0.785922081709697 0.206667413889409 no 2654 0.21595656853197 873 17158655
SGTC_2934 9036370 36.88 µM -0.785982266350767 0.206649759044017 no 2655 0.215938938245508 845 6462800
SGTC_1762 st045503 25.4615 µM -0.78654351591895 0.20648516246343 no 2656 0.215774567837828 858 4645554
SGTC_2907 7721985 69.9 µM -0.788520493362442 0.205905997040811 no 2657 0.215196158109882 862 3267881
SGTC_1926 methyl fluorone black 53.6 µM -0.790402676383287 0.205355498594006 no 2658 0.214646319841408 823 72721 Reacts with homocysteine.
SGTC_3116 9124943 49.47 µM -0.79309161104996 0.20457056082076 no 2659 0.213862225031495 843 41905195 YPL160W CDC60
SGTC_89 0302-0250 142.109 µM -0.793159437186714 0.204550784531209 no 2660 0.213842468482388 887 4203518 YLR208W SEC13
SGTC_2346 9031566 143.75 µM -0.793762082662298 0.204375119175707 no 2661 0.213666975235676 876 4771086
SGTC_575 k072-0246 11.9 µM -0.794266136180106 0.204228261419938 no 2662 0.213520256893609 875 6796779
SGTC_2384 9036245 200 µM -0.794428517851563 0.204180964338371 no 2663 0.213473003844216 846 6462766
SGTC_271 rotenone 740 µM -0.795506681124664 0.203867092067469 no 2664 0.213159413058384 878 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1590 st077108 57.8 µM -0.79835713705693 0.203038660562664 no 2665 0.212331634773956 857 5489485
SGTC_2252 omeprazole 400 µM -0.798537345614002 0.202986353975147 no 2666 0.212279365050696 853 4594 A proton pump inhibitor.
SGTC_153 4077-0274 519.67 µM -0.798890691632111 0.202883816588528 no 2667 0.212176898416941 863 3121976
SGTC_3346 9158254 43.5805 µM -0.801450194180258 0.202141999424481 no 2668 0.211435533328275 877 17639500
SGTC_765 1319-0117 244 µM -0.801560541925949 0.20211005402132 no 2669 0.211403605028944 851 3487746 YGL099W LSG1
SGTC_1570 verbenone 133 µM -0.801649690966097 0.202084247797971 no 2670 0.211377812479658 876 29025 A natural terpanoid with antifungal properties.
SGTC_2370 9071495 200 µM -0.802382367977253 0.201872232428232 no 2671 0.211165904617402 900 21791103
SGTC_1457 k015-0032 57.3 µM -0.803182595050145 0.201640822260278 no 2672 0.210934601943497 880 4302660
SGTC_2041 5107442 45.335 µM -0.804281761986379 0.201323223633218 no 2673 0.210617134084167 868 793005
SGTC_1429 4049-0205 9.46 µM -0.804993816657326 0.201117639246342 no 2674 0.210411623987106 852 22774478
SGTC_1825 st052143 62.6 µM -0.806926758039695 0.200560195651592 no 2675 0.209854340773102 881 674173
SGTC_250 brefeldin a 552.239 µM -0.809740089723403 0.199750515011118 no 2676 0.209044785862972 865 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1470 k295-0292 231 µM -0.809971381997825 0.199684036375583 no 2677 0.208978311890638 886 5045612
SGTC_2393 9031399 185.94 µM -0.810453319029385 0.19954555953594 no 2678 0.208839842000453 884 1526623 YDL150W RPC53
SGTC_2709 st078560 56 µM -0.811724506513255 0.199180581676959 no 2679 0.20847486453952 891 17250903
SGTC_2456 5770359 74.46 µM -0.812205288710401 0.199042646436763 no 2680 0.208336922675524 886 3118787
SGTC_1658 st012944 20 µM -0.812577154306631 0.198935998588461 no 2681 0.208230267155171 871 24207260
SGTC_2515 chrysin 20.77 µM -0.813745908712728 0.198601034178111 no 2682 0.207895264164263 865 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1175 0741-0056 27.6 µM -0.814176397918115 0.198477741966488 no 2683 0.207771952213026 880 765927
SGTC_2915 7971052 15.16 µM -0.816334737600766 0.197860289401077 no 2684 0.207154355843099 839 5741558
SGTC_506 n9-isopropylolomoucine 153 µM -0.817297952710706 0.197585110076348 no 2685 0.206879088235032 867 6610355
SGTC_3261 9137475 49.47 µM -0.817311786503955 0.197581159608882 no 2686 0.206875136391343 813 17027690
SGTC_458 nppb 133 µM -0.817822271345453 0.197435415647709 no 2687 0.206729339502106 882 4549 A chloride channel blocker.
SGTC_2776 terbinafine 19.92 µM -0.81941905618484 0.196979951772499 no 2688 0.206273683133725 859 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.820469851165456 0.196680572287409 no 2689 0.205974154721303 872 688761
SGTC_1785 bathophenanthroline 24 µM -0.820726641866602 0.196607452590432 no 2690 0.205900995945849 851 72812 An iron chelator.
SGTC_2099 5377090 177.372 µM -0.821773424947097 0.196309557473345 no 2691 0.205602930627762 881 2243829
SGTC_2608 thymoquinone 42.66 µM -0.823673321924136 0.19576958138904 no 2692 0.205062600940799 880 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2267 7931562 200 µM -0.823692029134666 0.195764269035917 no 2693 0.205057284819645 875 934880
SGTC_3250 9135583 49.47 µM -0.824011838919894 0.195673465047514 no 2694 0.204966415551599 878 7699353
SGTC_2481 5478948 45.16 µM -0.82430721979528 0.195589619908002 no 2695 0.204882508670356 871 77792
SGTC_262 fenpropimorph 62.5 µM -0.824697902392656 0.195478756475692 no 2696 0.204771561439893 900 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_863 0466-0191 129 µM -0.824858142512073 0.195433296409122 no 2697 0.204726066299765 890 765160 YPR165W RHO1
SGTC_3219 9131112 49.47 µM -0.825223065014673 0.195329791987584 no 2698 0.204622480476904 859 17612988 YMR079W SEC14
SGTC_706 4262-0057 46.9 µM -0.825979279805243 0.195115409818003 no 2699 0.204407922870936 887 883298
SGTC_487 nimodipine 119 µM -0.826476860395855 0.194974426871268 no 2700 0.204266819522958 863 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2664 lyso-paf C-16 73.48 µM -0.826684801034471 0.194915527968516 no 2701 0.204207869136711 883 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_15 0266-0086 27.098 µM -0.826873121053829 0.194862195916852 no 2702 0.204154489865693 906 1712902 YIL048W NEO1
SGTC_334 1502-1024 68.5 µM -0.831200126375399 0.193639237980171 no 2703 0.202930291723072 879 3296216
SGTC_2628 lathosterol 100 µM -0.832018747009023 0.193408395737109 no 2704 0.202699181419702 878 6710616
SGTC_746 1095-0025 46.6 µM -0.833417589727317 0.193014325867573 no 2705 0.202304628919497 879 6749286
SGTC_1912 st060209 90.8 µM -0.835918507571824 0.192311011907058 no 2706 0.201600374914732 892 688787
SGTC_2128 5255449 168.493 µM -0.838857899931612 0.191486395672943 no 2707 0.200774527510372 872 736008
SGTC_1740 st038286 13.222 µM -0.838904540875306 0.191473328521595 no 2708 0.200761439724865 877 716786
SGTC_685 1278-0033 54.9 µM -0.840015601684685 0.191162209922906 no 2709 0.20044981945337 894 3590572
SGTC_542 3381-0244 89.3 µM -0.840249302680605 0.191096808582007 no 2710 0.200384310115159 901 1112843
SGTC_2787 5284540 71.43 µM -0.840706316674376 0.190968952643879 no 2711 0.200256240497845 886 736958
SGTC_756 0508-1999 28.3 µM -0.842671962784635 0.190419634570869 no 2712 0.199705965914861 901 6753853
SGTC_3332 9141069 11.198 µM -0.842887927367552 0.190359340480613 no 2713 0.199645563029505 882 17332883
SGTC_1403 3909-7815 62.9 µM -0.844312593628007 0.18996188879137 no 2714 0.199247375288657 871 6615483
SGTC_564 3555-0129 330 µM -0.844707031934005 0.18985193909708 no 2715 0.199137216176397 863 563260
SGTC_2743 auranofin 4.32 µM -0.844732647773168 0.189844800034198 no 2716 0.199130063428956 841 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1305 1181-0477 144 µM -0.847332523725787 0.189121080633475 no 2717 0.198404901608187 900 6252086
SGTC_1683 st010134 710 nM -0.849951925924108 0.188393646554802 no 2718 0.197675907262247 915 3818134
SGTC_1988 st071872 53.4 µM -0.850145785086895 0.18833987861176 no 2719 0.197622019582892 877 16414116
SGTC_2886 9058944 51.95 µM -0.850226728768648 0.188317431222301 no 2720 0.197599522025188 844 4949929
SGTC_1176 0848-0131 83.3 µM -0.851822226949969 0.187875302898022 no 2721 0.197156383946099 897 6769040
SGTC_1847 st056231 15 µM -0.853563208527579 0.187393591665096 no 2722 0.196673525588527 873 5393180
SGTC_2681 menadione 3.18 µM -0.854496547495289 0.187135661266761 no 2723 0.196414960776764 897 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_381 3461-2219 42.7 µM -0.857157378000427 0.186401540630629 no 2724 0.195678957135708 919 2883159
SGTC_3317 9138495 8.753 µM -0.857418698259825 0.186329538948054 no 2725 0.195606764591229 888 17020139
SGTC_2744 captopril 92.04 µM -0.857563082703432 0.186289764032132 no 2726 0.195566883765814 856 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_875 0709-0210 25.7 µM -0.857984918716278 0.186173587111315 no 2727 0.195450395564681 891 6251364
SGTC_3060 1327-0027 12.5 µM -0.860443356361219 0.185497408013753 no 2728 0.194772347445758 869 16000455 YPR107C YTH1
SGTC_2920 7982904 15.77 µM -0.860716622538065 0.185422341971814 no 2729 0.194697067871952 876 6456808
SGTC_2750 bromebric acid 70.15 µM -0.860807016461912 0.185397514970539 no 2730 0.194672169981905 904 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2670 beta-carotene 100 µM -0.860965804096439 0.18535390839866 no 2731 0.194628438579332 843 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2982 9019404 25.97 µM -0.862657889838536 0.184889620048175 no 2732 0.194162795777654 862 22333232
SGTC_2941 9056145 11.23 µM -0.862859852604868 0.184834252170972 no 2733 0.19410726328033 879 2119517
SGTC_818 4072-2707 53.5 µM -0.865282795280094 0.184170808681325 no 2734 0.193441795754279 897 882871
SGTC_2198 6589944 200 µM -0.868523419628871 0.183285790029326 no 2735 0.192553928583211 881 5290268
SGTC_2983 9022671 12.99 µM -0.868687432754059 0.183241068456268 no 2736 0.192509058546884 882 6405161
SGTC_3200 9114385 49.47 µM -0.871109233678963 0.182581506627194 no 2737 0.19184725644036 881 17018030 YLR208W SEC13
SGTC_716 1683-5115 658 µM -0.871805553355253 0.18239214322941 no 2738 0.191657232260312 893 723597
SGTC_1979 st071809 45.3 µM -0.873122403063382 0.182034362936659 no 2739 0.191298182017326 913 4976333
SGTC_2711 st079103 59.1 µM -0.875701734089605 0.181334846459724 no 2740 0.190596101200674 904 54693780
SGTC_1855 st056195 39.6 µM -0.877411602436287 0.180872057917792 no 2741 0.190131556727188 865 4028379
SGTC_3073 9114972 49.47 µM -0.877413742910146 0.180871479046999 no 2742 0.190130975630314 862 41905075
SGTC_2068 5226020 147 µM -0.878529849920392 0.180569796693774 no 2743 0.18982812302292 921 1810509
SGTC_1338 1486-1223 76 µM -0.881631441577197 0.179733098551222 no 2744 0.188988073285497 900 3444526
SGTC_2803 7707263 71.43 µM -0.882045757253114 0.179621515756309 no 2745 0.188876031712154 908 2199229
SGTC_3048 9093155 49.47 µM -0.882170635649347 0.179587892258273 no 2746 0.188842269423302 855 25236002
SGTC_2421 5690543 90.72 µM -0.882785219195929 0.179422473330475 no 2747 0.188676163995248 901 3397993
SGTC_1606 st000094 49.2 µM -0.885597521224299 0.178666747637261 no 2748 0.187917223891618 882 1242210
SGTC_2175 5807670 165.306 µM -0.886233999802173 0.178495990771743 no 2749 0.187745722932845 853 241186
SGTC_2004 4023728 41.89 µM -0.887335706988744 0.178200663684918 no 2750 0.18744909339545 913 360084 YDR527W RBA50
SGTC_2193 5925765 200 µM -0.887544785230203 0.178144652303766 no 2751 0.187392832770337 900 877370
SGTC_2841 9004761 38.96 µM -0.888526781808906 0.177881727104009 no 2752 0.187128728099177 891 2991039
SGTC_2783 7738165 71.43 µM -0.888690755817504 0.177837847653182 no 2753 0.18708465028281 897 17201110
SGTC_2320 7373003 200 µM -0.888746026720234 0.177823058696192 no 2754 0.187069794371173 890 5415828
SGTC_1251 0490-5699 265 µM -0.889242521817713 0.17769024519668 no 2755 0.186936377357507 886 3883818
SGTC_1600 coumarin 106 71.1 µM -0.88931382844772 0.177671175662053 no 2756 0.186917220841083 903 100336 A hepatotoxic, DNA x-linker.
SGTC_2046 4110841 106 µM -0.889846668057057 0.177528719225923 no 2757 0.186774112007672 895 44119630 YMR134W ERG29
SGTC_2493 resveratrol 26.09 µM -0.890012162472797 0.177484488422092 no 2758 0.18672967770575 866 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_312 4092-0653 6.84 µM -0.89059283749732 0.177329349554913 no 2759 0.186573821557483 883 1148278
SGTC_1067 clotrimazole 1.36 µM -0.891088753898589 0.177196923449396 no 2760 0.186440778852107 885 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1397 3532-0190 20.1 µM -0.891912233638906 0.176977165094681 no 2761 0.186219988450342 863 5322280
SGTC_1976 st070609 63.5 µM -0.893287440080009 0.176610554036516 no 2762 0.185851631163907 885 682556
SGTC_1845 st056753 3.01 µM -0.896555580757891 0.175741241264401 no 2763 0.184978054732944 894 5375839
SGTC_3249 9135183 49.47 µM -0.899388767308512 0.174989822122181 no 2764 0.184222810083192 878 4902779
SGTC_1240 0356-0016 42.1 µM -0.899926891305804 0.174847331310923 no 2765 0.184079579131909 859 4305613
SGTC_2986 9022445 71.43 µM -0.901319464195521 0.174478931434699 no 2766 0.183709243868636 868 6459286
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.901931642265117 0.174317138166987 no 2767 0.183546590665145 902 688788
SGTC_2407 paclitaxel 400 µM -0.902425429141127 0.174186704126021 no 2768 0.183415458932744 943 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2675 theaflavin digallate 100 µM -0.902800148954539 0.174087763113949 no 2769 0.183315986044736 910 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_235 0330-0087 5 mM -0.90298720094825 0.174038387279407 no 2770 0.183266343928463 907 46494818 YHR062C RPP1
SGTC_289 k017-0060 526 µM -0.906285535857403 0.17316919371407 no 2771 0.182392369644294 908 5512909
SGTC_1478 0453-0656 35.7 µM -0.907403825598557 0.172875125117855 no 2772 0.182096643570216 923 5258496
SGTC_1471 k673-0312 37 µM -0.909648934234561 0.172285706477241 no 2773 0.181503841522768 892 24099884
SGTC_1511 0906-3109 28.5 µM -0.912113046213664 0.171640269627317 no 2774 0.180854605641414 907 2882180
SGTC_2921 7974240 10.71 µM -0.912514631207202 0.171535227096474 no 2775 0.180748935497063 890 2979074 YDR527W RBA50
SGTC_3235 9132602 49.47 µM -0.912971260517961 0.171415836552562 no 2776 0.180628828432669 909 4912240
SGTC_3153 9100258 49.47 µM -0.913389667511379 0.171306486277608 no 2777 0.180518818923073 919 25236848
SGTC_2513 baicalein 25.65 µM -0.913787038438717 0.171202675057312 no 2778 0.180414379230878 917 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1991 st073000 8.92 µM -0.914025378919914 0.171140429070593 no 2779 0.180351755178232 914 4301969 YIL048W NEO1
SGTC_2060 5238662 140 µM -0.917281160661409 0.170291585190561 no 2780 0.179497663420766 923 790130
SGTC_1726 st035556 14.5795 µM -0.918179262381222 0.170057908515767 no 2781 0.179262511817471 897 5919439
SGTC_181 1447-1644 8.07 µM -0.918514558699634 0.169970720631681 no 2782 0.179174770262731 943 534600
SGTC_1354 1498-1681 81 µM -0.920996274001146 0.169326285587424 no 2783 0.178526186169873 920 5754243
SGTC_1257 0669-0121 16 µM -0.921002699353165 0.169324619133607 no 2784 0.178524508857293 897 4307855
SGTC_572 0960-0087 17.7 µM -0.923000515941572 0.168806983882338 no 2785 0.178003468178495 920 6796365
SGTC_798 1287-0182 476 µM -0.928720909037092 0.167330457893513 no 2786 0.176516870950457 935 1649755
SGTC_68 0986-0284 82.829 µM -0.929994942601648 0.167002745942609 no 2787 0.176186851510387 886 423278 YIL048W NEO1
SGTC_38 0929-0051 58.268 µM -0.931574689242932 0.166596972468437 no 2788 0.175778184354203 914 1379719
SGTC_2663 amphotericin b 100 µM -0.931703455356738 0.166563925696013 no 2789 0.17574490013211 898 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2940 9060638 45.86 µM -0.933177861689516 0.166185832969483 no 2790 0.175364071547153 895 4027022
SGTC_383 2324-0395 7.37 µM -0.933750344074963 0.166039176690609 no 2791 0.175216344570683 863 3146421
SGTC_2269 7935389 174.42 µM -0.935491951722547 0.165593532866495 no 2792 0.174767414555773 900 97605
SGTC_1521 st012942 49.4 µM -0.937046352803937 0.165196445499311 no 2793 0.174367357536396 892 24207259
SGTC_3100 9120536 49.47 µM -0.937118110474143 0.165178129176194 no 2794 0.174348903287008 894 16421196
SGTC_1300 1094-0077 113 µM -0.937135677141468 0.165173645441126 no 2795 0.174344385775623 908 5532636
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.937155745574598 0.165168523249071 no 2796 0.174339224991581 924 23847180
SGTC_2999 9069765 71.4286 µM -0.93771871500406 0.165024874928601 no 2797 0.174194491724338 893 2097066
SGTC_430 0958-0115 16.4 µM -0.938764537460234 0.164758235711022 no 2798 0.173925824996644 912 6833180
SGTC_384 k007-0144 5.16 µM -0.94080613357708 0.164238522208633 no 2799 0.17340210855329 926 6824886
SGTC_180 1486-1293 102.781 µM -0.941197936513068 0.164138905651807 no 2800 0.173301717002307 908 4140536
SGTC_1205 4161-2785 76 µM -0.945193081457362 0.163125371079958 no 2801 0.172280155471413 928 3498106
SGTC_109 0132-0036 33.701 µM -0.945277716926397 0.163103943864967 no 2802 0.172258555760708 865 67274 A color developer.
SGTC_1579 chlormadinone acetate 49.4 µM -0.945352436576896 0.163085028564447 no 2803 0.172239488089653 934 45114258 A steroidal progestin.
SGTC_1436 4092-1007 8.32 µM -0.946905985398042 0.162692070264863 no 2804 0.171843343856846 886 2881121
SGTC_1484 3473-2379 286 µM -0.947613881627147 0.162513217755982 no 2805 0.171663028321977 959 671917
SGTC_3097 9117246 49.47 µM -0.947946369001531 0.162429257808825 no 2806 0.171578378773806 898 16423892
SGTC_669 0108-0021 26.2 µM -0.948606202123775 0.162262719899497 no 2807 0.171410467708501 914 17201
SGTC_66 0109-0187 42.4 µM -0.950128696282147 0.161878875861768 no 2808 0.171023431851236 909 759417
SGTC_1972 st070201 17.4 µM -0.951914851118582 0.161429313700994 no 2809 0.170570083553477 917 2829099
SGTC_2177 5811945 192 µM -0.953005825663576 0.161155124250412 no 2810 0.170293559511621 906 5343475
SGTC_2159 5658611 73.75 µM -0.953567427881036 0.161014097970808 no 2811 0.170151324945283 926 793844
SGTC_2666 tannic acid 100 µM -0.953661083836583 0.160990587470738 no 2812 0.170127612514581 895 16134267 A thiamine antagonist.
SGTC_2089 5281248 129.67 µM -0.95455213072024 0.160767019606697 no 2813 0.169902117330964 913 2737878
SGTC_1875 nocodazole 6 µM -0.955779517941837 0.160459394474883 no 2814 0.169591819194992 910 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3045 9092950 49.47 µM -0.957915204157738 0.159925036030587 no 2815 0.169052759508064 918 44120432
SGTC_198 3454-2873 16.191 µM -0.958360788884516 0.159813695611661 no 2816 0.168940430215666 914 710957
SGTC_75 0159-0059 199.013 µM -0.961586664581585 0.159009143239346 no 2817 0.168128636404228 911 5377270
SGTC_3202 9113761 49.47 µM -0.96174025351366 0.158970903557416 no 2818 0.168090048343394 919 4798415
SGTC_2748 diazoxide 86.69 µM -0.9618080853381 0.158954017101521 no 2819 0.168073007923511 851 3019 A potassium channel activatior.
SGTC_1146 3579-1023 7 µM -0.963993266828899 0.158410653965067 no 2820 0.167524650798572 942 X1146
SGTC_3338 9144300 39.5675 µM -0.964645990487361 0.158248585538053 no 2821 0.167361077836092 912 4901274
SGTC_3281 9140613 49.47 µM -0.964682264080975 0.158239582155993 no 2822 0.167351990670391 900 16013766
SGTC_2863 9028737 58.44 µM -0.965104574723556 0.158134786177801 no 2823 0.167246217915191 911 6460917
SGTC_1309 pyrazolanthrone 13.4 µM -0.965936031303217 0.157928594189219 no 2824 0.167038095630305 935 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_150 3970-0969 77.2 µM -0.966863397142881 0.157698826116217 no 2825 0.166806163358456 939 6615640
SGTC_991 3996-0057 64.7 µM -0.96991283317418 0.156944834008202 no 2826 0.16604497136532 908 715343
SGTC_1895 st058434 18.3 µM -0.971243909427586 0.156616461864324 no 2827 0.165713416473479 957 5393175
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.971652115322686 0.15651584949469 no 2828 0.165611823178568 937 4174840
SGTC_2669 eugenol 100 µM -0.971945731811579 0.156443506819109 no 2829 0.165538773528424 902 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2861 9024595 19.48 µM -0.974147275001403 0.155901781388822 no 2830 0.164991709663484 896 16482810
SGTC_1103 duloxetine 36.1 µM -0.977189030025702 0.155155345170675 no 2831 0.164237788944839 940 60835 A selective serotonin reuptake inhibitor.
SGTC_2201 6605497 169.863 µM -0.977733693847934 0.155021936015682 no 2832 0.164103026323049 921 670741
SGTC_861 0443-0273 110 µM -0.977783653972585 0.155009702650173 no 2833 0.164090668607178 931 6149169
SGTC_295 k015-0027 31 µM -0.978430584729053 0.154851351085005 no 2834 0.163930703779527 927 3887424
SGTC_2103 5378138 10 µM -0.97986803314731 0.154499884296353 no 2835 0.163575632105515 909 244142
SGTC_1627 st003713 25.6 µM -0.97999567032404 0.15446870157081 no 2836 0.163544127935077 932 16195070 YER133W GLC7
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.980693553315809 0.154298277057506 no 2837 0.163371941960163 885 279621
SGTC_803 4488-1585 147 µM -0.982778892345547 0.15378977394673 no 2838 0.16285813625944 910 747204
SGTC_3086 9117350 49.47 µM -0.98305103524234 0.153723494711003 no 2839 0.162791160695345 890 2679265
SGTC_351 caspofungin 25 nM -0.985261032872463 0.153185959651826 no 2840 0.162247934047126 895 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1149 3909-7961 23.3 µM -0.986786039096893 0.152815761432484 no 2841 0.161873770112979 925 735261
SGTC_2591 skatole 100 µM -0.986905637537387 0.152786753789562 no 2842 0.161844450141198 935 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1503 4585-0012 61.3 µM -0.987220711086267 0.152710352709718 no 2843 0.161767225336352 935 2922052
SGTC_1676 st018489 23.4 µM -0.989091046485632 0.152257343421269 no 2844 0.161309298926196 915 3696235
SGTC_311 1315-0136 58 µM -0.99074386332771 0.151857762062172 no 2845 0.160905333429907 928 6759207
SGTC_2888 9058547 12.99 µM -0.9915005609748 0.151675057221478 no 2846 0.160720609283658 912 16476514
SGTC_1259 0671-0132 43 µM -0.991615953442242 0.151647208524399 no 2847 0.160692451983361 918 X1259
SGTC_621 3584-0052 32.1 µM -0.993884284906337 0.151100461849096 no 2848 0.160139603006405 925 2273927
SGTC_2402 5553605 200 µM -0.994523740826673 0.150946568045816 no 2849 0.159983976593308 949 6758546
SGTC_2742 clothiapine 36.27 µM -0.997837105191797 0.150150832795297 no 2850 0.159179177138126 914 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3327 9140648 26.9345 µM -0.999471922171959 0.149759248344672 no 2851 0.158783067044836 932 8029710
SGTC_1612 st002233 45.4 µM -0.999648599444817 0.149716970016846 no 2852 0.158740297517948 908 1035021
SGTC_47 0149-0135 24.25 µM -1.00299578828493 0.148917502454652 no 2853 0.157931446681096 935 5239155
SGTC_2220 6782180 200 µM -1.00332336163845 0.148839415910506 no 2854 0.157852433956477 910 833803
SGTC_1315 1237-0019 3.69 µM -1.00380592476666 0.14872443294225 no 2855 0.157736084034611 925 825140
SGTC_2801 7907800 81.82 µM -1.00385961836818 0.148711642744437 no 2856 0.157723141551145 911 6620925
SGTC_3234 9132280 49.47 µM -1.00622051167231 0.148149988027399 no 2857 0.157154753685293 924 17612295
SGTC_1828 st055811 49 µM -1.00707499251688 0.14794705797369 no 2858 0.156949368800842 936 5877589
SGTC_2648 atorvastatin 78.68 µM -1.00714398032181 0.147930682230136 no 2859 0.156932794448568 925 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2415 st077333 57.7 µM -1.0072273036752 0.147910905252775 no 2860 0.156912777509454 901 2766255
SGTC_2199 6590217 200 µM -1.00770644256361 0.147797214960175 no 2861 0.156797705600636 874 703109
SGTC_427 1354-0053 47.3 µM -1.00789873755277 0.147751603576421 no 2862 0.156751538888059 958 6813657
SGTC_1933 st074711 15.9 µM -1.00963059794271 0.147341239941466 no 2863 0.156336152197382 922 17250958
SGTC_496 calpeptin 138 µM -1.01137355522178 0.146929018788629 no 2864 0.155918836592699 923 73364 A calpain inhibitor.
SGTC_1712 st032288 53.4 µM -1.0136727666514 0.146386424032729 no 2865 0.155369461529723 928 2883011
SGTC_954 1189-0853 2.85 µM -1.01484781024267 0.146109643632557 no 2866 0.155089189679186 919 2828194
SGTC_1199 1638-0010 4.46 µM -1.0158521824118 0.14587334355512 no 2867 0.154849891214622 923 3111136
SGTC_897 1000-0139 31.4 µM -1.02004621291049 0.144889384564085 no 2868 0.15385327207334 940 6151020
SGTC_3195 9113082 49.47 µM -1.02112197287025 0.144637722955165 no 2869 0.153598326992277 924 17018038
SGTC_2715 st079500 56.4 µM -1.02132329434057 0.144590658852146 no 2870 0.153550646773154 924 28246688
SGTC_93 0109-0045 59.227 µM -1.02151247368191 0.144546442689304 no 2871 0.153505851183871 945 88733
SGTC_1523 st012844 44.7 µM -1.02175521251166 0.144489721617314 no 2872 0.153448385974923 949 4274103
SGTC_865 0488-0499 301 µM -1.02216168803502 0.144394773584704 no 2873 0.153352190180077 923 9634651
SGTC_702 1488-0190 94 µM -1.0243065023915 0.143894465889362 no 2874 0.15284526381854 918 949357
SGTC_1417 3966-0327 90.4 µM -1.0253707333343 0.143646653830905 no 2875 0.152594146038895 956 651118
SGTC_1806 st050005 60.3 µM -1.02634416616544 0.143420236968069 no 2876 0.152364692964344 928 5194765
SGTC_946 3434-1334 87.4 µM -1.0269725180847 0.143274212679107 no 2877 0.152216702449553 918 4047976
SGTC_2221 6807166 181.081 µM -1.02740248930262 0.143174348463784 no 2878 0.152115489910313 910 674925
SGTC_1422 4031-0024 15.5 µM -1.02742715467587 0.143168621162119 no 2879 0.152109685191206 947 782427
SGTC_2130 NSC 7 2.4545 µM -1.02900712829361 0.142802073601274 no 2880 0.151738162606359 943 21448
SGTC_2143 5623677 140.463 µM -1.03058011862028 0.142437776812435 no 2881 0.151368881642858 898 5375313
SGTC_1674 st016616 23.6 µM -1.03212895358722 0.142079689012695 no 2882 0.151005855926161 929 625830
SGTC_968 1309-0633 340 µM -1.03230264702691 0.142039569440712 no 2883 0.150965180723231 941 3761976
SGTC_2899 9053889 58.44 µM -1.03358324592846 0.141744014433281 no 2884 0.150665517562779 922 6470052
SGTC_1451 4152-0210 104 µM -1.03452348886394 0.141527277032489 no 2885 0.150445750853816 956 659563
SGTC_3305 9127027 53.8275 µM -1.03522298983999 0.141366179318609 no 2886 0.150282392325271 938 41905295
SGTC_2918 7977171 22.06 µM -1.03567351371099 0.141262487799424 no 2887 0.150177241474852 920 2236483
SGTC_2829 7992743 58.44 µM -1.03748211063917 0.140846744409007 no 2888 0.149755614346031 948 16462845
SGTC_1106 tegaserod maleate 11.7 µM -1.03881471984642 0.140540948307404 no 2889 0.14944545706845 932 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_718 1130-0073 349 µM -1.04312684149141 0.139554528800768 no 2890 0.148444775343691 950 6740020
SGTC_342 k048-0088 23.3 µM -1.04339639593213 0.139493023619367 no 2891 0.148382371027617 939 6820570
SGTC_3095 9117207 49.47 µM -1.04368451680634 0.139427302458271 no 2892 0.148315687816138 933 17015229
SGTC_1213 1315-0166 115 µM -1.04425956294117 0.139296195838406 no 2893 0.148182658047159 930 768401
SGTC_1198 1612-1005 86.7 µM -1.04436260809106 0.139272711108223 no 2894 0.148158828271287 955 6998509
SGTC_618 k072-0232 33.2 µM -1.04504319627354 0.139117667832347 no 2895 0.148001502789752 919 5872756 YGL099W LSG1
SGTC_3123 9126162 49.47 µM -1.04537966484366 0.139041061089826 no 2896 0.147923765680309 919 25239884
SGTC_175 3793-3120 23.7 µM -1.04671323848597 0.138737717206529 no 2897 0.147615928055684 940 5322297
SGTC_988 1497-1057 103 µM -1.04819274068333 0.138401707221533 no 2898 0.14727490722925 943 3533044
SGTC_546 peri-Naphthalide 147 µM -1.04858444548888 0.138312840016114 no 2899 0.147184708922437 918 223824 A penicillin ester.
SGTC_2002 4023503 131 µM -1.04877599700452 0.138269396332617 no 2900 0.147140613624796 964 4736863 YCR052W RSC6
SGTC_1140 3229-1848 2.98 µM -1.04901224778973 0.138215827714517 no 2901 0.147086240722128 939 2849525
SGTC_1166 k206-0078 225 µM -1.05148318588086 0.137656403443582 no 2902 0.14651836391227 936 5404595
SGTC_1892 st058411 7.36 µM -1.05196428400262 0.137547662056452 no 2903 0.146407968198875 951 3934738
SGTC_2946 9065502 71.43 µM -1.05376526627474 0.137141111316536 no 2904 0.14599519971425 883 16489101
SGTC_3319 9138450 16.7555 µM -1.05425875629573 0.137029855132244 no 2905 0.1458822329735 917 2029690
SGTC_370 0180-0345 38.7 µM -1.05431279356504 0.137017676302127 no 2906 0.145869866659041 918 3989527
SGTC_422 cantharidin 155 µM -1.05436536035809 0.137005829595237 no 2907 0.145857837535976 954 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2122 5258151 111.688 µM -1.05443029853926 0.136991195778845 no 2908 0.145842978326588 949 2173356
SGTC_1877 wortmannin 25 µM -1.05512675460256 0.136834316589875 no 2909 0.145683678630659 945 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1834 st055981 52.8 µM -1.05625100526626 0.136581334353372 no 2910 0.145426776812032 946 471719 YDL150W RPC53
SGTC_955 1216-0110 33 µM -1.05882918633402 0.136002392756475 no 2911 0.144838789488379 945 3619719
SGTC_1119 parthenolide 318.541 nM -1.05959644195669 0.135830427067674 no 2912 0.144664116498118 972 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_519 k048-0011 62.8 µM -1.06302422098947 0.135063974929362 no 2913 0.14388548371699 926 6836379
SGTC_862 0452-0056 10.2 µM -1.06460976465875 0.134710452172259 no 2914 0.143526279592072 951 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_3324 9138759 60.749 µM -1.06579775652427 0.134445986537831 no 2915 0.143257537648491 951 45595710
SGTC_2794 7785382 27.27 µM -1.06714574237036 0.134146335703875 no 2916 0.142953014449172 932 2205081
SGTC_614 0462-0418 107 µM -1.06726882837613 0.134118997147345 no 2917 0.142925229926787 922 5188303
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.06952762859905 0.133617975992052 no 2918 0.142415993100438 941 688662
SGTC_3216 9129716 49.47 µM -1.07151235957077 0.133178809206037 no 2919 0.141969558188745 932 8056934
SGTC_87 0100-0052 35.5 µM -1.072085358005 0.133052205286828 no 2920 0.14184084738502 967 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1398 3558-0053 112 µM -1.07255176119325 0.132949214749645 no 2921 0.141736139084648 930 4532369
SGTC_1152 3909-8331 15.9 µM -1.07538560539985 0.132324628923029 no 2922 0.141101061864809 929 16001939
SGTC_2397 5161689 200 µM -1.0754184051558 0.132317411640327 no 2923 0.141093722606385 962 2259942
SGTC_1917 st066507 28.5 µM -1.07628345891355 0.132127162505329 no 2924 0.140900252016548 949 3156428
SGTC_91 0417-1751 58.384 µM -1.07656747307164 0.132064741121321 no 2925 0.140836771078999 970 6795624
SGTC_1051 3253-3903 78 µM -1.07694368515365 0.131982087547243 no 2926 0.140752712559966 929 5509239
SGTC_125 0133-0007 11.75 µM -1.07784242767967 0.131784778781483 no 2927 0.140552040874647 935 26541
SGTC_1727 st034309 9.9045 µM -1.07972853047808 0.131371368169277 no 2928 0.1401315425884 971 870305
SGTC_1189 1431-2119 7.28 µM -1.08039249616605 0.131226048352447 no 2929 0.139983717966044 947 3107275
SGTC_317 4495-0002 170 µM -1.08103258811175 0.131086058837654 no 2930 0.139841308922999 940 15991618
SGTC_1186 1319-0216 26 µM -1.08223618624479 0.130823108739084 no 2931 0.139573796556038 946 4565136
SGTC_2496 diffractaic acid 79.83 µM -1.0830730639982 0.13064049105084 no 2932 0.139387996902863 950 94870 An apoptosis inducer which activates caspases.
SGTC_2506 ethyl hematommate 54.16 µM -1.08478794552863 0.130266832242573 no 2933 0.13900779284712 949 3940691 An allergen.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.08625606987577 0.129947527836771 no 2934 0.138682858426605 958 229346 A bile salt which induces apoptosis.
SGTC_3129 9127257 49.47 µM -1.08695186861275 0.129796386998559 no 2935 0.13852904077429 954 837894
SGTC_483 fpl-64176 144 µM -1.08739657016099 0.129699853073281 no 2936 0.138430793161251 961 3423
SGTC_1980 st071811 45.7 µM -1.09001040093743 0.129133458879362 no 2937 0.137854281230579 947 4974850
SGTC_1413 3910-0535 34.4 µM -1.09108081569039 0.128902005039039 no 2938 0.137618661761183 944 2876951
SGTC_2960 9079389 5.97 µM -1.09395181178805 0.128282636149258 no 2939 0.136988056615986 961 16457355
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.09611535219261 0.127817256362443 no 2940 0.136514148493815 957 16486 A toxic proline analog.
SGTC_530 4358-1714 28 µM -1.09653687715961 0.127726722642491 no 2941 0.136421947122584 925 1564641
SGTC_60 0986-0278 202 µM -1.09922322168264 0.127150805736412 no 2942 0.13583535609421 945 3110598
SGTC_3230 9131665 49.47 µM -1.10297042258526 0.12635047710472 no 2943 0.135020004927779 925 15943720
SGTC_2975 9084847 53.72 µM -1.10420361243208 0.12608786127164 no 2944 0.134752411493928 954 27211724
SGTC_3246 9135460 32.98 µM -1.10475513559292 0.125970534046743 no 2945 0.134632852734684 940 41446951
SGTC_428 3448-4153 16.5 µM -1.10544970858606 0.125822883724688 no 2946 0.134482387351152 944 3834874
SGTC_2341 7987486 176.74 µM -1.10678950331801 0.125538415113199 no 2947 0.134192473768338 936 1258686
SGTC_2596 sinensetin 100 µM -1.10890485481368 0.125090192594243 no 2948 0.133735614638955 953 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.10952182934743 0.124959672452025 no 2949 0.133602566354937 933 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2045 5106652 78.05 µM -1.11114395693571 0.124616967494713 no 2950 0.133253194857653 934 673349
SGTC_3285 9112818 20.8695 µM -1.11127220376467 0.124589900991702 no 2951 0.13322560008036 956 17017947 YPR165W RHO1
SGTC_2626 ethyl orsellinate 100 µM -1.11266525467155 0.124296162234315 no 2952 0.132926111653154 962 75653 A natural product.
SGTC_2584 androsterone 48.74 µM -1.11267017063145 0.124295126513244 no 2953 0.132925055605002 895 2754130 A steroid.
SGTC_633 0437-0093 97.7 µM -1.11401065407745 0.124012931399596 no 2954 0.132637308019586 954 2831118
SGTC_1018 4259-0013 28.1 µM -1.11761787986126 0.123255775077764 no 2955 0.131865114543422 956 6801262
SGTC_1944 st076371 56.9 µM -1.11788247311971 0.123200364775127 no 2956 0.131808595789432 950 24208455
SGTC_2014 4013930 200 µM -1.11879936301029 0.123008487596112 no 2957 0.131612871758736 968 64556
SGTC_3076 9116187 49.47 µM -1.11895179380425 0.122976608785498 no 2958 0.131580352552691 952 27241210
SGTC_3176 9106582 49.47 µM -1.11952042958354 0.122857737516635 no 2959 0.131459090145029 929 17018027
SGTC_3284 9108171 64.8615 µM -1.12069973575496 0.122611464684325 no 2960 0.131207847361395 934 8687505
SGTC_247 mechlorethamine 29.705 µM -1.12237944164905 0.12226129234899 no 2961 0.13085057087039 938 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2738 aclarubicin 5.55 µM -1.12268437129814 0.122197798296841 no 2962 0.130785783957685 951 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1522 st012842 45.6 µM -1.12324293508944 0.122081551262536 no 2963 0.130667166150764 932 3491067 YOR116C RPO31
SGTC_3139 9095020 49.47 µM -1.12324949820047 0.122080185824437 no 2964 0.130665772836643 894 25236292
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.12430453325754 0.121860827949065 no 2965 0.130441927945164 987 91467 include heat shock
SGTC_2015 5119600 184 µM -1.12733438716544 0.121232414993805 no 2966 0.129800564352898 966 2828786
SGTC_2033 5192550 145 µM -1.12821121255066 0.121050981223025 no 2967 0.129615364857169 935 182073
SGTC_120 rhodamine 6G 52.259 µM -1.12886618967351 0.120915577264342 no 2968 0.129477142733937 973 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1045 1348-1485 165 µM -1.12944502109687 0.12079600371321 no 2969 0.129355074941775 960 6810614
SGTC_2204 7233102 200 µM -1.13096169285617 0.120483088259129 no 2970 0.129035607533408 938 2172480
SGTC_2322 7413319 38.22 µM -1.13179827963943 0.120310730511526 no 2971 0.128859625589377 926 1840400
SGTC_379 3970-0972 5.9 µM -1.13208187737077 0.120252341744268 no 2972 0.128800006602674 968 2898042 YBL034C STU1
SGTC_1886 st057356 49.9 µM -1.13295667663661 0.120072358713264 no 2973 0.128616223555776 963 24207747
SGTC_2644 guaiazulene 100 µM -1.1334491048923 0.119971129045792 no 2974 0.128512851378207 945 3515 A coloring agent.
SGTC_1874 staurosporine 7.6 µM -1.13575855078378 0.119497173366281 no 2975 0.128028814301525 951 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_344 k064-0035 6.43 µM -1.13613971040422 0.119419077115483 no 2976 0.127949048928077 931 5088750
SGTC_1739 st037196 92.5 µM -1.13990487780691 0.118649561979069 no 2977 0.127162966330979 954 612214
SGTC_2375 9072683 200 µM -1.14043857050573 0.118540771395081 no 2978 0.127051815747152 978 16798029
SGTC_2641 levomentholum 100 µM -1.14296255790787 0.118027224267015 no 2979 0.126527068511572 959 16666
SGTC_2898 9056270 58.44 µM -1.14665322060428 0.117279133861107 no 2980 0.125762485650972 911 19154699
SGTC_2926 9010726 65.15 µM -1.14726116366201 0.117156227833138 no 2981 0.125636849844863 984 2994293
SGTC_884 0851-0618 334 µM -1.14864273210944 0.116877259658369 no 2982 0.12535166448806 959 9642473
SGTC_3162 9099653 49.47 µM -1.15005347400124 0.116592886930348 no 2983 0.125060923739458 939 25237511
SGTC_1289 0976-0073 69.1 µM -1.15006431492001 0.116590703554915 no 2984 0.125058691352303 969 3391136
SGTC_2725 haloperidol 53.21 µM -1.15046336260682 0.116510354997274 no 2985 0.124976537893664 955 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1415 3966-0071 78.1 µM -1.15189795671362 0.116221822786421 no 2986 0.124681503990747 957 2893185
SGTC_657 3534-0529 86.7 µM -1.15226454503339 0.116148174255007 no 2987 0.124606190796772 995 1049549
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.15234478921976 0.116132057412382 no 2988 0.124589709392042 970 676296 Flavone; oxidizing agent.
SGTC_3119 9125183 49.47 µM -1.15262585302293 0.116075618972227 no 2989 0.12453199353461 933 22695334
SGTC_1279 0874-0590 65.2 µM -1.1533731844596 0.115925647330678 no 2990 0.124378621540212 967 3523074
SGTC_3152 9099253 49.47 µM -1.15379071758991 0.115841918291781 no 2991 0.124292990339973 937 25236131
SGTC_823 0417-1665 178 µM -1.1581497614043 0.114970351281124 no 2992 0.123401462968646 985 3429856
SGTC_3030 9087619 49.47 µM -1.15983466071994 0.114634717744933 no 2993 0.123058064625905 945 25236973
SGTC_2521 angolensin 13.4 µM -1.15983957454723 0.114633739926701 no 2994 0.123057064122254 962 821428 A flavenoid.
SGTC_3009 9080819 71.4286 µM -1.16010350727139 0.114581227829701 no 2995 0.123003333197384 974 17027216
SGTC_96 0929-0093 37.281 µM -1.16365845824618 0.113875601986819 no 2996 0.122281225355176 971 6991579
SGTC_251 melphalan 456.522 µM -1.16440513299043 0.113727788100764 no 2997 0.122129934203252 970 460612 A DNA alkylator.
SGTC_2638 epoxomicin 18 µM -1.16488081509257 0.113633692044146 no 2998 0.122033620113403 949 9915668 A protesome inhibitor.
SGTC_2708 st078559 56 µM -1.1679969067204 0.113018661439957 no 2999 0.121404006312662 933 17250902
SGTC_826 1683-5028 118 µM -1.1687243550429 0.1128754258697 no 3000 0.121257353033578 961 722377
SGTC_1400 3771-8998 51.5 µM -1.17008408356658 0.112608041053215 no 3001 0.120983566500907 966 670767
SGTC_793 0488-0545 106 µM -1.1710572774086 0.112416944592332 no 3002 0.120787877453671 972 292548
SGTC_3160 9100216 49.47 µM -1.17636327908938 0.111379132273503 no 3003 0.119724869508534 967 17191039
SGTC_2008 4012253 172 µM -1.17858306310091 0.110947000725066 no 3004 0.119282119546975 943 603940
SGTC_1465 k213-0056 144 µM -1.17937948404299 0.110792252358455 no 3005 0.119123550373603 924 24048857 YMR208W ERG12
SGTC_539 4859-0462 2.54 µM -1.18055651639974 0.110563832662832 no 3006 0.118889473203813 949 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_632 0781-2353 4.65 µM -1.18179001507403 0.110324817334885 no 3007 0.118644515340025 992 6811515 YHR007C ERG11
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.1828912375566 0.110111746448998 no 3008 0.118426127405374 992 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1325 1431-0015 227 µM -1.18384754595168 0.1099269540013 no 3009 0.118236708617353 961 1103340
SGTC_2455 5377712 9.75 µM -1.18409789003589 0.109878615487092 no 3010 0.118187157635411 947 2243908
SGTC_922 1866-0035 480 µM -1.18909362765373 0.108917184837055 no 3011 0.117201412837903 953 3156169
SGTC_3114 9122766 49.47 µM -1.19368294420481 0.108039313095898 no 3012 0.116301007350562 930 17176985
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.19459645920411 0.107865180184128 no 3013 0.116122366661767 970 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_589 1227-0070 34.1 µM -1.19789623636897 0.107237865390187 no 3014 0.115478707573809 970 2841384
SGTC_1157 4092-0394 27.6 µM -1.19813676476811 0.107192242036036 no 3015 0.115431889099916 979 3659885
SGTC_1346 1488-2224 62.4 µM -1.19845816403299 0.107131300968756 no 3016 0.115369350295912 955 3722427
SGTC_2524 avocatin b 10.57 µM -1.19848793968275 0.107125656421452 no 3017 0.115363557682386 967 6710748
SGTC_1754 st042065 16.137 µM -1.20146282384293 0.106562790583974 no 3018 0.114785859503706 942 1126236 YIL048W NEO1
SGTC_1767 st044992 70.3 µM -1.20146345948888 0.106562670544537 no 3019 0.11478573628679 969 9600693
SGTC_712 r015-0009 80.6 µM -1.20148793868571 0.106558047811054 no 3020 0.114780991183562 981 6813872 YLR060W FRS1
SGTC_253 dyclonine 31.25 µM -1.20697746449093 0.105525040648053 no 3021 0.113720411415321 985 3180 An oral anasthetic.
SGTC_1171 0368-0077 21.4 µM -1.21326963378028 0.104349924742274 no 3022 0.112513374385191 979 3239779
SGTC_157 1348-1695 65.819 µM -1.21554954455211 0.103926481421539 no 3023 0.112078282242682 941 5380510
SGTC_1629 st005085 44.9 µM -1.21571196119546 0.103896363717787 no 3024 0.112047333037756 945 24207091
SGTC_1696 st025591 34.7925 µM -1.21591647355683 0.103858449005913 no 3025 0.112008370999949 956 2787147
SGTC_2525 harmine 47.85 µM -1.2164950410201 0.103751242273043 no 3026 0.111898199481631 943 5280953 A monoamine oxidase inhibitor
SGTC_2451 5856223 45.7 µM -1.21662241306841 0.103727651418975 no 3027 0.11187395555308 973 2179896
SGTC_269 exalamide 29 µM -1.21734954553024 0.103593052151592 no 3028 0.111735625474249 980 3316 A derivative of salicylamide.
SGTC_2647 atorvastatin 60.16 µM -1.21791833727172 0.103487851668179 no 3029 0.111627503538509 947 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2505 galangin 7.89 µM -1.22043413584603 0.103023473782309 no 3030 0.11115017175888 985 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2671 danthron 100 µM -1.22057867591682 0.102996839952382 no 3031 0.111122792101687 983 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2860 9025725 38.96 µM -1.22349351763631 0.102460800610239 no 3032 0.110571675541802 994 40546248
SGTC_1832 st054113 55 µM -1.22440378536252 0.102293818756982 no 3033 0.110399971021535 971 1251267
SGTC_883 0850-0245 24.6 µM -1.22649825194737 0.10191035624903 no 3034 0.110005616365969 969 6823229 YPR165W RHO1
SGTC_3318 9139014 38.6185 µM -1.2265671858457 0.101897753388879 no 3035 0.109992654414423 978 16643984
SGTC_697 0508-1955 564 µM -1.22718195517647 0.10178540817086 no 3036 0.109877105031727 971 6243113
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.22810164918734 0.101617508276064 no 3037 0.109704406012639 985 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2212 7123476 200 µM -1.22873419647716 0.10150214717202 no 3038 0.109585740209762 965 1085715
SGTC_3016 9080866 49.47 µM -1.229862235332 0.101296657339692 no 3039 0.109374349036395 985 17066299
SGTC_2360 9040895 200 µM -1.23084627650399 0.101117646598894 no 3040 0.109190181949293 975 4914414
SGTC_1089 terbinafine 2.25 µM -1.23398627795448 0.100547978558817 no 3041 0.108604008765968 966 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_167 3672-0051 66.205 µM -1.2370146735271 0.100000779791284 no 3042 0.108040817554847 968 3237971
SGTC_3020 9089140 49.47 µM -1.2374386100754 0.0999243528285383 no 3043 0.10796214609986 998 17217859
SGTC_1782 st039423 80.636 µM -1.23774867885064 0.0998684808792594 no 3044 0.107904631629017 1000 2068169
SGTC_107 0358-0022 2.6945 µM -1.23826946117452 0.0997746913619865 no 3045 0.107808081688373 1005 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1438 4092-1045 4 µM -1.23937636698199 0.0995755585652677 no 3046 0.107603074667061 973 1351342
SGTC_748 act1.228 77.9 µM -1.24167435846168 0.0991630766547242 no 3047 0.107178367145146 985 4421505 YNR035C ARC35
SGTC_1882 5615643 20 µM -1.24338505767288 0.0988568241056559 no 3048 0.106862986925709 937 2253075
SGTC_1647 st011722 22.4 µM -1.25175422481988 0.0973685315244162 no 3049 0.10532971730718 970 2854783
SGTC_1671 st016596 74.5 µM -1.25294140993715 0.0971587521901315 no 3050 0.105113515057939 996 2829167
SGTC_2298 7976326 193.81 µM -1.25694630621833 0.0964535213663425 no 3051 0.104386539563368 987 2235818
SGTC_1303 1160-0052 261 µM -1.26339933371689 0.0953251183343897 no 3052 0.103222851741247 962 3562476
SGTC_3040 9091894 49.47 µM -1.26376040860386 0.0952622676276545 no 3053 0.103158017764103 960 25236966
SGTC_1317 1273-0028 910 nM -1.26597638670871 0.094877210254218 no 3054 0.102760768193227 967 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_3337 9144342 33.5465 µM -1.26600614490611 0.0948720471635923 no 3055 0.102755441134986 980 17682949
SGTC_713 1488-1073 324 µM -1.26607259058473 0.0948605194886785 no 3056 0.102743547321647 1003 3312542
SGTC_2607 solasodine 47.35 µM -1.26812870250704 0.0945043141085353 no 3057 0.102375996495606 983 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_500 h-89 112 µM -1.26836440310087 0.0944635439026858 no 3058 0.102333923792917 994 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2141 5621638 7.665 µM -1.26910768781847 0.0943350594915165 no 3059 0.102201329362282 991 2856238
SGTC_3166 9102297 49.47 µM -1.26920224775186 0.0943187230796093 no 3060 0.102184469797306 982 25237072
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.27243271039439 0.093761872747298 no 3061 0.101609709062633 1029 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1055 3448-0672 86 µM -1.27327178877379 0.0936176346422904 no 3062 0.101460806941866 979 748378
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.27597845147072 0.0931534743623003 no 3063 0.100981568273617 990 1273210
SGTC_2839 9003951 25.97 µM -1.27683318280017 0.0930072520755771 no 3064 0.100830573871216 963 2990634
SGTC_1078 idebenone 36.1 µM -1.2855071743155 0.0915329445274176 no 3065 0.0993075556596444 997 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2775 cyproheptadine 69.59 µM -1.28640419719483 0.0913814724354078 no 3066 0.0991510171818779 978 2913 A selective serotonin reuptake inhibitor.
SGTC_3315 9136395 68.55 µM -1.29199047368502 0.0904423483640058 no 3067 0.0981802218308574 992 16876844
SGTC_672 1441-0018 53.7 µM -1.2936060716601 0.0901720863835722 no 3068 0.0979007620785776 975 251141
SGTC_3330 9141424 71.43 µM -1.29383400148416 0.0901340059526575 no 3069 0.0978613826526982 982 27261020
SGTC_3269 9137823 49.47 µM -1.29579187294199 0.0898073946382399 no 3070 0.0975235993833494 959 17682936
SGTC_784 4579-0127 173 µM -1.29796327611437 0.0894461918470205 no 3071 0.0971499773277734 996 1948547
SGTC_816 0325-0417 81.3 µM -1.30139803924122 0.0888770431554459 no 3072 0.0965611222277899 978 68101
SGTC_1971 st069429 63.5 µM -1.30157732853057 0.0888474086949017 no 3073 0.0965304570721368 970 1246522 YGL099W LSG1
SGTC_3173 9105693 49.47 µM -1.30180256508467 0.0888101901067667 no 3074 0.0964919433610145 993 17096658
SGTC_3024 9090631 49.47 µM -1.3019074202343 0.0887928675698609 no 3075 0.0964740177920652 978 25236383
SGTC_2237 6667747 47.222 µM -1.30263928710346 0.088672029969334 no 3076 0.0963489692294 1012 729940 YDL015C TSC13
SGTC_2746 daunorubicin 9.88 µM -1.30352564238002 0.0885258490252749 no 3077 0.0961976839390589 972 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2463 5473429 200 µM -1.30382202391189 0.0884770087768679 no 3078 0.0961471357903875 980 5399405
SGTC_986 1493-0483 84 µM -1.30621613376393 0.0880832229986785 no 3079 0.0957395338719087 996 40079
SGTC_704 1310-0270 142 µM -1.30715096597896 0.0879298160186632 no 3080 0.0955807224286857 985 5718033
SGTC_1573 oleylamine 1.06 µM -1.31027700470368 0.0874182767734718 no 3081 0.0950510718476094 984 5356789 An amine of the fatty acid oleic acid.
SGTC_92 0063-0024 660.874 µM -1.3133475838985 0.086917978552298 no 3082 0.0945329256237655 1029 3594437
SGTC_1096 rimcazole 32.2 µM -1.31365912636199 0.0868673378167712 no 3083 0.0944804708374185 993 18528119 A dopamine reuptake inhibitor.
SGTC_3351 9150312 21.596 µM -1.31587733984131 0.0865074077911526 no 3084 0.0941076077573716 989 4904905
SGTC_2843 9000894 45.46 µM -1.31631553197752 0.0864364382659889 no 3085 0.0940340799225415 954 2242070
SGTC_1668 st014914 51.6 µM -1.31640788901309 0.0864214856920301 no 3086 0.0940185879920017 1003 2839556
SGTC_717 1532-0246 73.2 µM -1.31910421692438 0.0859858030889314 no 3087 0.0935671367951948 979 9561992
SGTC_797 k781-0471 270 µM -1.3195727790123 0.0859102590150097 no 3088 0.0934888481124632 968 23738129
SGTC_2189 6047310 154.431 µM -1.31967357242269 0.0858940150582863 no 3089 0.0934720135883493 993 711535
SGTC_298 1391-0729 10 µM -1.32269576703361 0.0854080225684157 no 3090 0.0929682858987871 1000 3237558
SGTC_3010 9080089 71.4286 µM -1.32303424454923 0.0853537212537668 no 3091 0.0929119949798051 992 17027233
SGTC_3136 9095672 49.47 µM -1.32332940918264 0.0853063896568285 no 3092 0.0928629278343226 953 17217380
SGTC_19 0279-0214 38.434 µM -1.32388055003279 0.0852180632246075 no 3093 0.0927713593817446 1000 3566274 YBR002C RER2
SGTC_1789 tunicamycin 25 nM -1.33224482019742 0.0838859949839416 no 3094 0.0913898764267244 969 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3069 9117009 49.47 µM -1.33433906410783 0.0835549329021859 no 3095 0.0910463803216465 989 41904981
SGTC_2115 tiliquinol 12.7705 µM -1.33734994224613 0.0830806892955949 no 3096 0.0905542180166613 999 71208 A bioactive hydroxyquinoline.
SGTC_2604 4'-hydroxychalcone 11.32 µM -1.33840970697418 0.0829142482362003 no 3097 0.0903814581633489 1011 5282362
SGTC_2084 5306078 60.6385 µM -1.3413765201871 0.0824496303406875 no 3098 0.0898991184602564 1009 679340
SGTC_2834 9001755 58.44 µM -1.34479513853967 0.0819166912435121 no 3099 0.0893457003215358 993 2989575
SGTC_2976 9009005 19.48 µM -1.34606377460023 0.0817195814067303 no 3100 0.0891409750494691 981 2993148
SGTC_2420 aureobasidin a 50 nM -1.34972536936954 0.0811526793486239 no 3101 0.0885520457772501 991 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1997 st073024 93.8 µM -1.3499769115403 0.0811138438372526 no 3102 0.0885116944991026 1007 686268
SGTC_655 k060-0012 42 µM -1.35183525588967 0.0808273690986797 no 3103 0.0882140114884988 1018 5994525
SGTC_3299 9121982 43.1275 µM -1.35192170125949 0.0808140616525723 no 3104 0.0882001822316665 997 17594604 YPL160W CDC60
SGTC_69 0096-0274 206.684 µM -1.3563544498017 0.08013389705592 no 3105 0.0874932093596381 1011 6741392
SGTC_390 dec-rvkr-cmk 16.7 µM -1.35921691093739 0.0796969836662474 no 3106 0.0870389320396168 1001 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1697 st025554 27.742 µM -1.35972593527545 0.0796194775281837 no 3107 0.086958333862594 995 1269519
SGTC_178 4092-0806 87.505 µM -1.35997814187784 0.0795810966485609 no 3108 0.0869184204952881 958 2169044
SGTC_2050 5263056 171 µM -1.36919941171112 0.0781873944017909 no 3109 0.0854684749360756 998 763468 YGL055W OLE1
SGTC_2444 5485484 36.41 µM -1.37116565427928 0.0778926256552961 no 3110 0.0851616610909717 1025 6790631
SGTC_1271 0832-2808 169 µM -1.37319316364305 0.0775895560522194 no 3111 0.0848461522015681 1003 3663794
SGTC_1142 3253-1408 9.78 µM -1.37329458651948 0.07757441903279 no 3112 0.0848303924271854 1018 256655
SGTC_3001 9076041 71.4286 µM -1.37426697796605 0.0774294067000342 no 3113 0.0846794070293418 1006 16004211
SGTC_244 nsc-207895 1.295 µM -1.38322688148152 0.0761028935806411 no 3114 0.0832976548473525 977 42640
SGTC_2350 9023895 38.85 µM -1.38469509682062 0.0758871839742969 no 3115 0.0830728594987699 982 2997209
SGTC_1504 k297-0033 30 µM -1.38493642823853 0.0758517722596328 no 3116 0.0830359534563893 956 4388117
SGTC_2129 girgensonine 121.053 µM -1.38585010169162 0.0757178185845556 no 3117 0.0828963400130403 1009 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1284 0929-0043 16 µM -1.38752636919621 0.0754725296670852 no 3118 0.0826406580549442 1001 1239883
SGTC_3180 9109287 49.47 µM -1.38800680335527 0.0754023393090022 no 3119 0.0825674867291691 986 18891271
SGTC_1003 4049-0218 100 µM -1.38829890466276 0.0753596882870725 no 3120 0.0825230228132226 999 295161
SGTC_1756 st041558 35.5 µM -1.39223491342512 0.0747867659171313 no 3121 0.0819256367872275 1017 3955792
SGTC_3265 9137266 49.47 µM -1.39468688974269 0.0744315418232445 no 3122 0.0815551400274417 972 17224265
SGTC_3297 9117502 71.43 µM -1.39469692291048 0.0744300909434079 no 3123 0.0815536266027459 1004 7453720
SGTC_1311 1190-0148 100 µM -1.39505036010256 0.0743789947505974 no 3124 0.0815003268853535 997 1961333
SGTC_2105 5350118 200 µM -1.39596279146923 0.0742472089429623 no 3125 0.0813628501004008 1004 2133313
SGTC_889 0919-1524 82.7 µM -1.3982784339732 0.0739135528183329 no 3126 0.0810147357065351 1002 3905452
SGTC_2831 7999036 19.48 µM -1.39974624613668 0.0737026528807224 no 3127 0.0807946599057857 1020 2988270
SGTC_1137 ixabepilone 100 µM -1.39993439920431 0.0736756517435612 no 3128 0.0807664819257023 1001 154225 A novel microtubule stabilizer.
SGTC_1379 2144-0755 36.5 µM -1.40081420003756 0.0735494951862012 no 3129 0.0806348205930019 1001 5392327
SGTC_3124 9127567 49.47 µM -1.40174617501646 0.0734160374955693 no 3130 0.0804955283230252 991 17592030
SGTC_2156 5649887 115 µM -1.4102846562422 0.0722019452044276 no 3131 0.0792278236649951 1033 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2546 rhodinyl acetate 100 µM -1.41226542288325 0.0719225100232683 no 3132 0.0789359117045546 982 6708682
SGTC_2032 5185112 25.99 µM -1.4133019633724 0.0717766117569473 no 3133 0.07878347848066 991 5718189
SGTC_2688 kanamycin b 96.69 µM -1.4136574319237 0.0717266300847362 no 3134 0.0787312548113981 982 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2466 5983409 37.09 µM -1.41839172507487 0.0710634943287871 no 3135 0.0780382150905414 1025 2879657
SGTC_1223 0764-0573 147 µM -1.42183746237471 0.0705838153810477 no 3136 0.0775367207005155 1004 1609797
SGTC_945 3381-0768 11.3 µM -1.4249429331648 0.070153640397858 no 3137 0.0770868488985632 1021 1126236 YIL048W NEO1
SGTC_2567 aureobasidin a 60 nM -1.42569602368434 0.070049625482198 no 3138 0.076978052403889 990 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2741 miltefosine 3.04 µM -1.4264943943762 0.0699394861901612 no 3139 0.0768628419214674 995 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1531 st059297 52.4 µM -1.43050352566647 0.0693884198034805 no 3140 0.0762862773235636 1009 7566702
SGTC_1602 st001878 87.6 µM -1.43119051061911 0.069294328331422 no 3141 0.0761878112279737 1013 595405 YLR310C CDC25
SGTC_1891 st059073 26.2 µM -1.43286438643106 0.0690654809123448 no 3142 0.0759482983119101 1018 688754
SGTC_1027 k015-0025 8.67 µM -1.43892474462587 0.0682417960495733 no 3143 0.075085922911308 1007 3598955
SGTC_1604 st002052 72.4 µM -1.4427432997782 0.0677267091486336 no 3144 0.0745463984208301 1010 6254834 YHR062C RPP1
SGTC_416 estradiol valerate 100 µM -1.45037890418578 0.0667057510962859 no 3145 0.0734764432959227 1019 13791 A steroid.
SGTC_3190 9110366 49.47 µM -1.45358407179519 0.0662807532832146 no 3146 0.0730308277905355 1015 17123768
SGTC_3111 9122088 49.47 µM -1.45717878522197 0.0658066006903002 no 3147 0.0725335175438312 1006 16876704
SGTC_2247 cerulenin 830 nM -1.45999213196915 0.0654373498523747 no 3148 0.0721461181696745 997 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_3208 9114115 49.47 µM -1.46053451779501 0.0653663470138665 no 3149 0.0720716140370217 1006 650895
SGTC_524 r073-0010 27.8 µM -1.47218951526803 0.0638550064311425 no 3150 0.0704848539585716 1025 2772106
SGTC_1120 ficusin 1.78878 µM -1.47562942397891 0.0634141766386984 no 3151 0.070021700846518 1020 6199 A DNA cross-linker.
SGTC_246 cycloheximide 667 µM -1.47921415796326 0.0629573115402196 no 3152 0.0695415433951791 1024 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1768 st044301 37.178 µM -1.4799956846343 0.062858049250621 no 3153 0.0694371991573048 1045 3931349
SGTC_1026 k007-1105 30.6 µM -1.49086345983226 0.0614903284155752 no 3154 0.0679986732645023 1007 7066794
SGTC_2439 5492030 7.2 µM -1.49333957417551 0.0611819820568985 no 3155 0.0676741607421978 990 5722370
SGTC_476 mead acid 10 µM -1.49625388363012 0.0608206174705531 no 3156 0.0672937538494665 1041 5312531 An omega 9 fatty acid.
SGTC_3068 9116768 49.47 µM -1.49761828441198 0.0606520109696982 no 3157 0.06711622673287 1018 41904888
SGTC_1866 st057638 64 µM -1.49973103029644 0.0603916490150573 no 3158 0.0668420446061296 997 688802
SGTC_1872 amphotericin b 148 nM -1.50827576685143 0.0593475600320269 no 3159 0.06574198135364 1008 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_400 oxethazaine 37.5 µM -1.51053917137839 0.0590733771215496 no 3160 0.0654529510116017 1016 4621 A local anesthetic.
SGTC_1086 cerivastatin 2.18 µM -1.51281208738609 0.0587990429001775 no 3161 0.0651636988005318 1002 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1260 0700-1617 7.75 µM -1.51561772915687 0.0584617901987586 no 3162 0.0648080207092931 996 2853078
SGTC_2335 9018011 154.17 µM -1.5161676479545 0.0583958654970377 no 3163 0.0647384831666819 1011 6458208
SGTC_3081 9117243 49.47 µM -1.51883996682115 0.0580763366413235 no 3164 0.064401391528898 1028 45595589
SGTC_2989 9073649 71.4286 µM -1.51926802976846 0.0580252811112263 no 3165 0.06434752177276 1025 21367202
SGTC_3334 9142812 21.919 µM -1.52091377054704 0.0578293202584789 no 3166 0.0641407388986349 1017 45283678
SGTC_1327 1436-0082 2.18 µM -1.5211986818334 0.0577954483318029 no 3167 0.0641049930798402 1022 15992205
SGTC_2820 7989630 71.43 µM -1.52928630734155 0.0568404341471611 no 3168 0.0630967412934969 1003 2984098
SGTC_512 prima-1 270 µM -1.53283275059552 0.0564255975387307 no 3169 0.0626585344648174 1032 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1763 st044482 94.5 µM -1.5401106890839 0.0555817538094511 no 3170 0.0617666873486564 1024 88505
SGTC_1998 st075797 76.8 µM -1.54251428049601 0.0553052669550335 no 3171 0.0614743352101212 1017 24208315
SGTC_858 0438-0351 2.77 µM -1.54595513113425 0.0549113551730323 no 3172 0.0610577022115644 1042 2799119
SGTC_2598 perillyl alcohol 100 µM -1.54843453278503 0.0546288879829303 no 3173 0.0607588561967861 1031 10819 An apoptosis inducer.
SGTC_2365 9042475 200 µM -1.55408818510234 0.0539890894442359 no 3174 0.0600816915247873 1007 6464479
SGTC_867 0518-0118 155 µM -1.55468666074864 0.0539217112692973 no 3175 0.0600103565176527 1005 6848158
SGTC_2879 9041815 71.43 µM -1.55644487215033 0.0537241516140425 no 3176 0.0598011709910997 1029 4942971
SGTC_2717 st081029 62.2815 µM -1.55807875792519 0.0535410759975565 no 3177 0.0596072897499162 1019 5292846
SGTC_2329 6138490 200 µM -1.56081331544385 0.0532357772206816 no 3178 0.0592839023906892 1035 720019
SGTC_2035 5154463 94.595 µM -1.5647913329474 0.0527941185697696 no 3179 0.0588159223134274 1027 2769623
SGTC_2476 5806916 10.51 µM -1.56854025935377 0.0523805601326952 no 3180 0.0583775510229472 988 2870194
SGTC_2126 5251174 33.877 µM -1.57463579625935 0.051713633394433 no 3181 0.0576702676433613 1033 790722
SGTC_2239 6685329 187.64 µM -1.57670251396769 0.0514890475193488 no 3182 0.0574319958366269 1000 805680
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.57827617074384 0.051318562237486 no 3183 0.0572510889148632 993 4000243
SGTC_1215 3852-0577 11.2 µM -1.58207450804794 0.0509089115261549 no 3184 0.0568162811500405 1021 2884876
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.58385408984038 0.0507178812581812 no 3185 0.0566134634903563 1024 756377
SGTC_602 3130-1533 38.1 µM -1.5858896251092 0.0505000758999364 no 3186 0.0563821748582623 1035 720941
SGTC_2782 7736369 71.43 µM -1.59108351849356 0.0499476971804918 no 3187 0.0557953905821461 1020 2950836 YOL077C BRX1
SGTC_2545 solidagenone 89.61 µM -1.59727675457585 0.0492953469174996 no 3188 0.0551020150142485 1005 6708572 An anti ulcer agent
SGTC_1488 4013-0813 75.9 µM -1.60106473120709 0.0488997138129148 no 3189 0.0546812913870926 1023 2910057
SGTC_470 aa-861 153 µM -1.60244722522172 0.0487559535417726 no 3190 0.0545283744485544 1013 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2205 7238770 200 µM -1.60246251829831 0.048754365164234 no 3191 0.054526684782557 1032 279867
SGTC_2406 ethylparaben 405.7 µM -1.60433938456638 0.0485597428940925 no 3192 0.0543196321181807 1032 8434 A possible steroid mimic.
SGTC_2107 5363541 170.161 µM -1.60903077999698 0.0480759833879459 no 3193 0.0538048057006042 1028 244052
SGTC_2532 xanthone 78.9 µM -1.62190850223684 0.0467678833344855 no 3194 0.0524114704006714 1050 7020 An insecticide.
SGTC_2933 9026794 32.47 µM -1.62561026875218 0.0463971935310141 no 3195 0.052016294670882 1021 17586027
SGTC_1024 4507-0395 26 µM -1.6263935768855 0.0463190572944819 no 3196 0.0519329781774434 1043 4201836
SGTC_910 3454-3003 490 µM -1.63393828601737 0.0455718582371831 no 3197 0.0511359048051297 1024 820824
SGTC_2827 7993847 71.43 µM -1.6361934178231 0.0453504096568774 no 3198 0.0508995567916984 1019 2985692
SGTC_939 1165-0479 45.3 µM -1.63934022715674 0.0450428479424137 no 3199 0.0505712112984796 1017 1377347
SGTC_1220 1838-0075 193 µM -1.63969492468554 0.0450082861698043 no 3200 0.0505343073729051 1015 5529645
SGTC_2953 9074162 66.49 µM -1.64012750091802 0.0449661647791658 no 3201 0.0504893297247849 1021 16451992
SGTC_1097 itavastatin 7.23 µM -1.65032608143561 0.0439822553042446 no 3202 0.0494381303100497 1043 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1505 k297-0037 20.6 µM -1.6533779563059 0.0436912240192311 no 3203 0.0491269831499611 1034 4089396
SGTC_2543 pimpinellin 60.67 µM -1.65800266211013 0.0432531686940403 no 3204 0.0486584645244062 1035 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1720 st037298 9.481 µM -1.66519396417864 0.0425790558227001 no 3205 0.0479370323894647 1040 597396
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.67253545510271 0.0418996533154791 no 3206 0.0472093912471662 1059 390807
SGTC_1721 st082152 9.2685 µM -1.67287654075682 0.0418683028857302 no 3207 0.047175801447868 1027 5296051
SGTC_2473 5854593 8.94 µM -1.67596462496118 0.0415853293771024 no 3208 0.046872560948382 1040 2872951
SGTC_471 1-acyl-paf 4 µM -1.68290123793649 0.0409553475159324 no 3209 0.0461971059594574 1056 16759367
SGTC_3027 9089541 49.47 µM -1.68379403354066 0.0408748292567494 no 3210 0.0461107403494465 1049 9943819
SGTC_3240 9133527 49.47 µM -1.68518368912649 0.0407497564072119 no 3211 0.0459765684958058 1034 17617455
SGTC_3150 9097574 49.47 µM -1.69088788565027 0.0402396127889094 no 3212 0.0454291087257636 1036 17217476
SGTC_2856 9022925 19.48 µM -1.69561210945095 0.0398210491051819 no 3213 0.0449796814833664 1041 4944862
SGTC_1693 xanthone 101.9 µM -1.70997674720963 0.0385700492540246 no 3214 0.0436350864996218 1058 7020 An insecticide.
SGTC_1974 st069448 26.9 µM -1.7130508483614 0.0383065334350084 no 3215 0.0433515926820021 1040 6323587 YNR016C ACC1
SGTC_454 lyso-paf C-16 6.67 µM -1.71973222914825 0.0377388581628409 no 3216 0.0427405632800512 1043 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2358 9037157 4 µM -1.72266278832378 0.0374920425599656 no 3217 0.0424747616534995 1030 2388925
SGTC_711 k292-0785 179 µM -1.73029034354346 0.036855815525175 no 3218 0.0417892069764608 1034 4146315
SGTC_2796 7949634 45.45 µM -1.74504954991801 0.035649795939049 no 3219 0.0404881221173503 1030 2971588
SGTC_3164 9100705 49.47 µM -1.75039074887736 0.0352214011638089 no 3220 0.0400254556231467 1032 17174235
SGTC_2469 5655019 90.81 µM -1.75329818349705 0.0349899890166269 no 3221 0.0397754185808628 1055 2788239
SGTC_3199 9111318 49.47 µM -1.75492041444069 0.0348614137093493 no 3222 0.039636460878854 1036 8548020
SGTC_2447 5741742 33.78 µM -1.75492109141369 0.0348613601346783 no 3223 0.0396364029729452 1044 1776504
SGTC_465 cgp-37157 41 µM -1.76636807569363 0.0339650777272696 no 3224 0.0386670586868278 1054 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.76881440110709 0.0337760128584488 no 3225 0.0384624263377486 1050 521171
SGTC_2840 9008771 71.43 µM -1.76928427011619 0.0337397982272315 no 3226 0.0384232235577629 1048 2992978
SGTC_1969 st069479 40.1 µM -1.78120667469203 0.0328315309412871 no 3227 0.0374393468305181 1051 3895485
SGTC_3213 9129884 49.47 µM -1.78238939856646 0.032742538625148 no 3228 0.037342876558652 1042 17190742
SGTC_1340 1486-1359 257 µM -1.78691557604623 0.0324038081508327 no 3229 0.0369755673144605 1041 4309068
SGTC_2373 9071805 200 µM -1.78724749707633 0.0323790820249068 no 3230 0.0369487478382686 1058 10149009
SGTC_3071 9117417 49.47 µM -1.78894563627839 0.0322528242907498 no 3231 0.0368117855789503 1042 45595590 YGL055W OLE1
SGTC_232 clozapine 119 µM -1.79238920438621 0.0319980401329092 no 3232 0.0365353214429965 1065 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_531 3788-1495 174 µM -1.79418133700325 0.031866102035244 no 3233 0.0363921149883119 1037 2896655
SGTC_21 0849-0113 22.993 µM -1.79971545930098 0.0314615095650456 no 3234 0.035952789399702 1053 1560156
SGTC_1614 st002383 48.6 µM -1.80060741750941 0.0313966987689836 no 3235 0.0358823896140208 1055 1947235
SGTC_998 3996-0085 177 µM -1.80076731113464 0.0313850923745825 no 3236 0.0358697815989433 1057 715391
SGTC_3232 9132874 49.47 µM -1.80335119537542 0.0311980241754634 no 3237 0.0356665385839398 1051 3784940
SGTC_691 1548-0686 185 µM -1.80964765537979 0.0307460321962568 no 3238 0.0351752223560291 1041 46495133
SGTC_2702 st077768 96.8 µM -1.81179538940948 0.0305931024499333 no 3239 0.0350089088970941 1045 6484119
SGTC_2088 5278280 127.392 µM -1.8133211276147 0.0304848451905896 no 3240 0.0348911532595326 1062 791502
SGTC_1229 0139-0193 12.2 µM -1.83339241251581 0.0290900203888214 no 3241 0.0333721175797772 1041 3090752
SGTC_2828 7998861 71.43 µM -1.83483240364344 0.0289920227664976 no 3242 0.0332652629041617 1034 2988188
SGTC_1916 st067606 49.2 µM -1.84430439554218 0.028354228515649 no 3243 0.0325693956382333 1024 19590279
SGTC_2235 salicylic acid 500 µM -1.84730170557833 0.0281548538684217 no 3244 0.0323517129534842 1072 338 A COX inhibitor and kinase inhibitor.
SGTC_3308 9128332 17.569 µM -1.84845723717298 0.0280783027378978 no 3245 0.0322681125703558 1050 17332805 YDL196W YDL196W
SGTC_395 anisomycin 6.25 µM -1.84884566875939 0.0280526090521371 no 3246 0.0322400503993373 1062 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2753 fluvastatin 17.09 µM -1.86463475450492 0.0270246584848877 no 3247 0.0311163089384245 1060 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1769 st044406 64.4 µM -1.86543272127978 0.0269735524855571 no 3248 0.0310603872063342 1071 670903
SGTC_609 0986-0026 86.3 µM -1.86714556830688 0.0268641251190712 no 3249 0.030940631201772 1040 2848610
SGTC_2261 9010538 184.68 µM -1.86856033419811 0.0267740207607667 no 3250 0.0308420043357752 1056 6457250
SGTC_2176 5809774 33.9695 µM -1.87810880061159 0.0261724701609809 no 3251 0.0301831413276602 1034 2870539
SGTC_2309 7664088 163.95 µM -1.88473250715066 0.0257618516169373 no 3252 0.0297329806126052 1036 704922
SGTC_3283 9109332 35.8195 µM -1.89201564923657 0.0253165907559784 no 3253 0.0292444478868046 1031 17027281
SGTC_1885 st057546 99.9 µM -1.89217256677161 0.0253070688758023 no 3254 0.0292339961117518 1038 702008
SGTC_2097 5376186 200 µM -1.90357639757956 0.0246230636619094 no 3255 0.0284826875732887 1057 742755
SGTC_2192 5915882 198.485 µM -1.91121501947021 0.0241736266876257 no 3256 0.0279884772554177 1062 2876149
SGTC_2866 9034245 58.44 µM -1.92158829143189 0.0235743394595852 no 3257 0.0273287915153808 1060 6462273
SGTC_2508 celastrol 40.54 µM -1.92188256047018 0.0235575228119834 no 3258 0.0273102683450643 1034 122724 Celastrol is a natural product and antioxidant.
SGTC_2759 disulfiram 3.38 µM -1.92462776939085 0.0234011274457964 no 3259 0.0271379713746567 1040 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2116 5511452 16.8835 µM -1.92567485457429 0.0233417053068511 no 3260 0.0270724927747345 1060 870744
SGTC_2412 st077135 33.4 µM -1.93563495177775 0.022782791944809 no 3261 0.0264562132264073 1065 13258915
SGTC_2859 9028643 45.46 µM -1.93576305267458 0.0227756776369163 no 3262 0.0264483640048287 1039 17151580
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.94975365666046 0.0220098728030797 no 3263 0.0256027438070614 1063 5393153
SGTC_1597 7-benzyloxygramine 47.5 µM -1.95053011028486 0.0219680164398992 no 3264 0.0255564840793242 1036 260807
SGTC_3205 9113483 49.47 µM -1.95118231214997 0.0219329100812489 no 3265 0.0255176811531298 1050 17018033
SGTC_3133 9127736 49.47 µM -1.95138144968449 0.0219222004616157 no 3266 0.0255058432478331 1050 27243420
SGTC_2650 prasterone 100 µM -1.95483134120618 0.0217373649881184 no 3267 0.0253014903004409 1068 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2555 cholic acid 100 µM -1.95711774341189 0.021615592766635 no 3268 0.0251668133906617 1056 6708657 Influences liver metabolism.
SGTC_1433 4060-0023 7.6 µM -1.96362396361322 0.0212722257120248 no 3269 0.0247868581370948 1064 3840627
SGTC_1332 1480-0653 17.5 µM -1.96513036266627 0.0211933862092044 no 3270 0.0246995756125045 1061 5749438
SGTC_349 k015-0014 24 µM -1.96669207062148 0.0211119131174192 no 3271 0.0246093607986972 1054 2196908
SGTC_396 dithiazanine 1.25 µM -1.96778270883764 0.0210551726442898 no 3272 0.0245465222662978 1062 10578 An antihelmenthic.
SGTC_2010 4012422 159 µM -1.96823864737699 0.0210314907086551 no 3273 0.0245202927200327 1055 952393
SGTC_2054 5233173 129 µM -1.98926290999923 0.0199636904902163 no 3274 0.0233360956441244 942 6889
SGTC_1524 corynanthine 62.1 µM -1.99018187326252 0.019918086068511 no 3275 0.023285452183162 1061 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2296 7971656 126.45 µM -1.99053941761336 0.019900366493949 no 3276 0.0232657731621347 1063 666570
SGTC_2065 5221596 34.26 µM -1.99325720814349 0.0197661120327061 no 3277 0.0231166447949451 1058 788581
SGTC_2167 5876490 200 µM -1.99545005805779 0.0196583499265727 no 3278 0.022996907975381 1057 686534
SGTC_1182 1222-0449 220 µM -1.99698406607324 0.0195832618337392 no 3279 0.0229134569708852 1061 658318
SGTC_2255 7941087 197.44 µM -2.01141797500181 0.0188885887936466 no 3280 0.0221406631452037 1078 935561
SGTC_166 k072-0058 166.424 µM -2.02990473970199 0.0180295747263816 no 3281 0.0211831116108182 1048 5846229
SGTC_1218 1348-1416 30.7 µM -2.03527937812365 0.0177861717185814 no 3282 0.020911384966405 1055 6787668
SGTC_1835 st008666 49.2 µM -2.03672288121339 0.0177212788788371 no 3283 0.0208389101182681 1066 690455
SGTC_3128 9127691 49.47 µM -2.03675191069231 0.0177199759303599 no 3284 0.0208374548013572 1059 41316314
SGTC_2027 5150920 200 µM -2.04517398188586 0.0173453986356126 no 3285 0.0204188542989267 1057 786715
SGTC_2118 5526350 200 µM -2.04818635210697 0.0172130735568418 no 3286 0.0202708716076243 1069 743594
SGTC_433 pimozide 108 µM -2.073851838054 0.0161202342021486 no 3287 0.0190465365608811 1074 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1987 st072290 61.9 µM -2.07974057479454 0.0158780498522453 no 3288 0.018774667164493 1070 54697379
SGTC_2352 9027995 87.8 µM -2.11103119820209 0.0146428536160498 no 3289 0.017384815181997 1061 2997347
SGTC_2737 bleomycin 30.5 nM -2.11196282534643 0.014607382024158 no 3290 0.0173448189819244 1076 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_3062 9077494 49.47 µM -2.11621536859397 0.0144464045021102 no 3291 0.0171632473539856 929 16459633
SGTC_1459 k035-0031 35.7 µM -2.12296286261677 0.0141941164029409 no 3292 0.0168784819942507 1048 3877128 YMR208W ERG12
SGTC_1066 ketoconazole 628 nM -2.12650124553669 0.0140633403637678 no 3293 0.016730772827802 1072 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2443 5493264 126.67 µM -2.13606151081018 0.0137151811335947 no 3294 0.0163372002256346 1075 5340055
SGTC_3251 9135047 49.47 µM -2.15133555588238 0.0131743713788475 no 3295 0.015724861880251 1081 17682963
SGTC_854 0422-0053 192 µM -2.16009195648293 0.0128727203495691 no 3296 0.0153827757910399 1077 3596728
SGTC_2331 7980721 200 µM -2.16818142949623 0.0125993715212929 no 3297 0.0150724425892385 1056 2981221
SGTC_749 1000-0129 128 µM -2.16865136505378 0.0125836476581567 no 3298 0.0150545811842597 1077 708470
SGTC_2646 retinol 96.75 µM -2.17069150984068 0.012515581985422 no 3299 0.0149772497059903 1068 445354 A vitamin A analog and teratogen.
SGTC_1849 st056239 19.2 µM -2.17518276111177 0.0123668620785255 no 3300 0.0148082117436695 1068 5393181
SGTC_412 gemfibrozil 100 µM -2.18040598547958 0.0121958316762211 no 3301 0.0146136904297095 1065 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -2.19015719874934 0.0118820163806249 no 3302 0.0142564190713502 1077 2374 Ca(2+)-ATPase inhibitor.
SGTC_2639 lactacystin 53 µM -2.19945612792844 0.011589305986364 no 3303 0.0139227527000501 1063 3870 A proteasome inhibitor.
SGTC_1568 digitonin 820 nM -2.20466228515216 0.011428177259686 no 3304 0.0137389007664977 1056 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_790 1575-0012 79.1 µM -2.2097076582577 0.0112738852903487 no 3305 0.0135627289570004 1051 378741 YLR208W SEC13
SGTC_1216 1165-0504 9.65 µM -2.21431658973508 0.0111345257640184 no 3306 0.0134035040965895 1085 6304004
SGTC_2570 licareol 100 µM -2.22802728999986 0.0107287772171051 no 3307 0.0129393476189161 1063 443158
SGTC_2423 st077119 87.2 µM -2.24573681724294 0.0102237851655258 no 3308 0.012360435225568 1069 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2736 butenafine 14.65 µM -2.24628726130406 0.0102084270265567 no 3309 0.0123428069916971 1071 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_475 α-linolenic acid 10 µM -2.27110078772055 0.00953667480358984 no 3310 0.0115704386646601 1065 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2908 7930301 100 µM -2.27966845161922 0.00931387789755437 no 3311 0.0113136798850248 1068 2223178
SGTC_2536 dehydroabietamide 32.04 µM -2.28012410715671 0.00930215745154088 no 3312 0.0113001644130077 1076 3983547
SGTC_147 4466-0538 29.23 µM -2.29586437182356 0.00890512808898149 no 3313 0.0108418187141764 1075 6742687 YHR072W ERG7
SGTC_2697 mebhydrolin 72.4 µM -2.31949702751256 0.00833690742946087 no 3314 0.0101840510586338 1080 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_788 1182-0090 188 µM -2.32402800206843 0.00823167823760327 no 3315 0.010061996644345 1081 5715185
SGTC_1625 st003711 30.1 µM -2.33612651198954 0.00795639396167963 no 3316 0.00974232446049885 1080 24207034 YER133W GLC7
SGTC_1173 0443-0020 122 µM -2.36078357667666 0.00742030643882253 no 3317 0.00911818487903131 1085 5331295
SGTC_750 4073-0104 132 µM -2.36765207575874 0.00727675770408259 no 3318 0.00895068068155576 1026 22330957
SGTC_1765 st044815 90.4 µM -2.40443870649562 0.00654884366020094 no 3319 0.00809866108975263 1078 645695
SGTC_1183 1254-0324 198 µM -2.40944978971666 0.00645484308268406 no 3320 0.00798829713786155 1078 5799357
SGTC_1094 duloxetine 25.4 µM -2.41934603238598 0.00627270422174874 no 3321 0.00777422073529239 1081 60834 A selective serotonin reuptake inhibitor.
SGTC_502 l-744,832 89.3 µM -2.42736354600391 0.00612849518607966 no 3322 0.00760450346606559 1084 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_943 3253-1379 105 µM -2.46278591528683 0.00552592455813511 no 3323 0.00689311027268425 1068 668464
SGTC_1615 st002656 86.5 µM -2.49220927971508 0.00506604686593117 no 3324 0.00634756054356909 1087 1584458
SGTC_2911 7942208 15.64 µM -2.49373783504064 0.00504311540149113 no 3325 0.00632029341943727 1067 1243384
SGTC_2081 5214970 32.255 µM -2.51147143778473 0.00478375375315 no 3326 0.00601145073857604 1083 2063512
SGTC_2978 9011784 42.97 µM -2.5677187558512 0.00403799754229712 no 3327 0.00511850873874678 1060 2994934
SGTC_1723 st034307 2.5525 µM -2.57783250740981 0.00391553054100897 no 3328 0.00497110880838144 1071 867466
SGTC_2080 5212524 12.4 µM -2.61675863218152 0.00347463429726474 no 3329 0.00443845434090853 1086 260183
SGTC_1571 st070080 73.4 µM -2.63978849437863 0.00323529485482114 no 3330 0.00414788912000055 1086 4315245
SGTC_613 3914-0030 117 µM -2.66206494315129 0.00301800369816454 no 3331 0.00388314463757338 1071 1145395
SGTC_2067 5224629 34.075 µM -2.67621100074923 0.00288693538178584 no 3332 0.00372298756737124 1083 2835000
SGTC_441 propafenone 146 µM -2.73487339058251 0.00239646318650912 no 3333 0.00312021369197248 1091 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2474 5321570 43.32 µM -2.75253327495049 0.00226433844074751 no 3334 0.0029568068213968 1090 2841384
SGTC_1681 tripelennamine 100 µM -2.77737047062415 0.0020896733618936 no 3335 0.00274003387857269 1079 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2052 5265182 7.135 µM -2.78038928142473 0.00206929877120026 no 3336 0.00271468852062572 1087 1239884
SGTC_2312 7706453 155.7 µM -2.78526304177157 0.00203678489048898 no 3337 0.00267421578787008 1086 976098
SGTC_1082 camptothecin 424.86 nM -2.79389850050849 0.00198031250548775 no 3338 0.00260384106042564 1062 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2172 5754775 163.918 µM -2.90978969760566 0.00134829568246116 no 3339 0.00180836014219387 1085 2263357
SGTC_3055 9094636 49.47 µM -2.93573015034351 0.00123490377767449 no 3340 0.00166381829718787 1086 25236176
SGTC_2971 9092186 9.93 µM -3.01518470514889 0.000939697124619419 yes 3341 0.00128411401886715 1079 25236400
SGTC_856 0433-0016 11.3 µM -3.07325171549926 0.000766606134619501 yes 3342 0.00105869901133534 1095 3911780
SGTC_844 0330-0132 15.3 µM -3.13487269709243 0.000615410750678919 yes 3343 0.000859643518502374 1094 2828079
SGTC_2874 9043904 71.43 µM -3.16300177465463 0.000555995613527038 yes 3344 0.000780756898669463 1084 4463428
SGTC_2955 9076254 12.21 µM -3.2000633158108 0.00048579885759064 yes 3345 0.000686987002729507 1088 16459619
SGTC_491 tetrandrine 80.3 µM -3.21199289300895 0.000465011338288269 yes 3346 0.000659088180970527 1091 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3049 9092223 49.47 µM -3.31915114055657 0.00031196812921191 yes 3347 0.000451457725194119 1091 8623917
SGTC_310 1273-0058 1.06 µM -3.32797086901629 0.000301732265268323 yes 3348 0.000437405067851349 1074 2734232
SGTC_432 NS 1619 61.3 µM -3.43541333944997 0.000199721088350044 yes 3349 0.000295825329377357 1089 4552 A K+/calcium channel activator.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -3.52411733620184 0.00014083612187634 yes 3350 0.000212448023887487 1093 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2756 carbadox 75.1 µM -3.60318921626773 0.000102470951359512 yes 3351 0.000157168265785688 1083 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1107 amlodipine 47 µM -3.60873377877061 0.000100187675940399 yes 3352 0.000153847582143395 1039 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_361 000s-0510 1.45 µM -3.90948666066823 2.81777549630706e-05 yes 3353 4.62462312306706e-05 1092 660
SGTC_2693 st077581 40.7 µM -4.16857681557483 8.78225991825417e-06 yes 3354 1.53253732506662e-05 1089 25238761
SGTC_1718 roemerine 11.9335 µM -4.59475521347374 1.11322341335299e-06 yes 3355 2.16628783991829e-06 1087 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2161 5662504 8.5105 µM -5.17264305187283 5.03391410506431e-08 yes 3356 1.15402835725512e-07 1094 2859334