SGTCid condition conc unit YMR254C|YMR254C.score YMR254C|YMR254C.strain.pval YMR254C|YMR254C.strain.significant YMR254C|YMR254C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1135 dihydrocapsaicin 536.708 nM 5.36285994382041 1.47629810968837e-08 yes 1 4.09572599089747e-08 11 107982 A Capsaicinoid. SGTC_1680 diphenhydramine 100 µM 4.77042602262128 4.09807916233678e-07 yes 2 9.19183465223488e-07 14 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1508 1080-0625 72.9 µM 3.86375062087609 3.28159613405614e-05 yes 3 5.58296089962278e-05 20 767111 SGTC_1749 st037932 54.2 µM 3.82617925015506 3.86409279999655e-05 yes 4 6.50737684332288e-05 31 594497 SGTC_136 0097-0015 404.482 µM 3.74042181249565 5.58052474168146e-05 yes 5 9.18558444209807e-05 20 4861337 SGTC_430 0958-0115 16.4 µM 3.67454257550323 7.36357712302257e-05 yes 6 0.000119137955513397 33 6833180 SGTC_278 4092-0821 23.9 µM 3.64556002120165 8.30720311283115e-05 yes 7 0.000133405065142971 51 877900 SGTC_2004 4023728 41.89 µM 3.62605869521452 9.0049445899547e-05 yes 8 0.000143889984523323 35 360084 YDR527W RBA50 SGTC_525 k781-2675 26.7 µM 3.60869717600376 9.67213998968325e-05 yes 9 0.000153869286801192 63 3651118 YDL195W SEC31 SGTC_3020 9089140 49.47 µM 3.57986521429315 0.000108837506513704 yes 10 0.00017188574028518 36 17217859 SGTC_2823 7987624 58.44 µM 3.56628706023769 0.000115024417102191 yes 11 0.000181037377336274 46 2239440 SGTC_2401 5128683 200 µM 3.52546728516108 0.000135670519254856 yes 12 0.000211368193499889 55 708373 SGTC_597 k018-0003 82.8 µM 3.51774911380444 0.000139945524171531 yes 13 0.00021761181482982 20 6786234 SGTC_2629 bisabolol 100 µM 3.47237695648706 0.000167738983712153 yes 14 0.000257935713461796 35 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1376 2910-0861 41.3 µM 3.43800234698335 0.000192147989894772 yes 15 0.000293011309630902 37 1112859 SGTC_1673 st016611 27.3 µM 3.40239651900312 0.000220903687526752 yes 16 0.000333988230137314 67 5226799 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 3.38619363582576 0.000235277450942078 yes 17 0.00035434679082989 54 23665772 A membrane-active detergent. SGTC_2053 5265679 138 µM 3.29367501901759 0.000335503628863441 yes 18 0.000494433784471605 51 764595 SGTC_2852 9023854 51.95 µM 3.2845765771031 0.000347256683911948 yes 19 0.00051067869293154 47 19798528 SGTC_491 tetrandrine 80.3 µM 3.27891523539219 0.000354761749097841 yes 20 0.000521034657202541 25 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3125 9127534 49.47 µM 3.26258674332327 0.000377260570603941 yes 21 0.000552001901825155 26 1639235 SGTC_2288 7946289 167.31 µM 3.24068372210227 0.000409524287767555 yes 22 0.000596217022742269 63 1246052 SGTC_69 0096-0274 206.684 µM 3.18767360013234 0.00049849804232408 yes 23 0.000717111673940838 87 6741392 SGTC_1315 1237-0019 3.69 µM 3.14460132222644 0.000583628012977505 yes 24 0.000831566538684595 31 825140 SGTC_251 melphalan 456.522 µM 3.05642190259314 0.000801294887918791 yes 25 0.00111997912349353 69 460612 A DNA alkylator. SGTC_952 1185-0122 232 µM 2.94986526896137 0.00116311633768863 no 26 0.00158956265842742 66 678600 SGTC_1849 st056239 19.2 µM 2.91467405113279 0.00131215970995322 no 27 0.00178030101762668 79 5393181 SGTC_1177 0983-0204 23.6 µM 2.90699036516148 0.00134694059490526 no 28 0.00182462218727195 53 766818 SGTC_571 k831-0106 44.2 µM 2.88710178742334 0.00144091598138417 no 29 0.00194404212690592 56 4783639 SGTC_2184 6075246 200 µM 2.8829190802951 0.00146142593097482 no 30 0.00197004320903887 69 2267320 SGTC_1298 1079-1278 263 µM 2.86986816816035 0.00152714566201808 no 31 0.00205321483464287 60 2840950 SGTC_2664 lyso-paf C-16 73.48 µM 2.83827925882978 0.00169751972608884 no 32 0.00226787400611052 51 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1586 deoxycorticosterone acetate 53.7 µM 2.83058938605659 0.00174153276407721 no 33 0.00232311632752126 58 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_3214 9129694 49.47 µM 2.82013192379641 0.00180305280758694 no 34 0.00240019548884352 80 17158655 SGTC_1987 st072290 61.9 µM 2.80894329410424 0.00187105742672461 no 35 0.00248522002957803 69 54697379 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 2.76508565128059 0.00216068935352387 no 36 0.00284539256247405 73 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2692 st077426 47.7 µM 2.75387756075562 0.00224095401216841 no 37 0.00294468981350064 87 25238571 SGTC_2552 juarezic acid 87.02 µM 2.74339111914883 0.00231848697051165 no 38 0.00304041051192173 115 1549512 SGTC_90 0870-0863 4.608 µM 2.72338699137627 0.00247316001434833 no 39 0.0032308158998216 121 1738164 SGTC_2978 9011784 42.97 µM 2.71697571374688 0.00252467205262432 no 40 0.00329407208926863 122 2994934 SGTC_2748 diazoxide 86.69 µM 2.71230904991779 0.00256277467394747 no 41 0.00334081325771108 50 3019 A potassium channel activatior. SGTC_1417 3966-0327 90.4 µM 2.70584648970286 0.00261639880945145 no 42 0.00340652661111171 86 651118 SGTC_1755 st041960 45.185 µM 2.70245569050743 0.00264493811663146 no 43 0.0034414678882107 89 2257073 SGTC_884 0851-0618 334 µM 2.7001035072252 0.00266490057969471 no 44 0.00346589531170573 89 9642473 SGTC_324 1315-0088 19.6 µM 2.69654475267465 0.0026953616863212 no 45 0.00350314911879651 63 6787421 SGTC_174 3553-0389 74.3 µM 2.66865545470413 0.00294517801071833 no 46 0.00380777637474355 88 738071 SGTC_231 b-estradiol 524 µM 2.62345624197876 0.0033946080784969 no 47 0.00435213126682414 54 450 A steroid. SGTC_2116 5511452 16.8835 µM 2.61915133993967 0.00344047475389801 no 48 0.00440744155198127 85 870744 SGTC_718 1130-0073 349 µM 2.5823263876457 0.0038561538306 no 49 0.00490683623160436 104 6740020 SGTC_949 1165-0505 146 µM 2.55637586598366 0.00417555330297207 no 50 0.00528844007759701 121 6244267 SGTC_2497 7-hydroxyflavone 100 µM 2.55607165371956 0.00417943390506322 no 51 0.00529306586787763 99 5281894 SGTC_2859 9028643 45.46 µM 2.54969894066866 0.00426147080370132 no 52 0.00539079890992586 76 17151580 SGTC_1245 0418-0076 17.2 µM 2.54081703038384 0.00437821046469905 no 53 0.00552968891682473 113 6790114 SGTC_2620 irigenin 100 µM 2.53863068024968 0.0044073815764222 no 54 0.00556436162081103 132 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2000 st075254 36.4 µM 2.52910486883386 0.00453651510413842 no 55 0.00571769268405218 70 17234175 SGTC_1045 1348-1485 165 µM 2.52601134761432 0.00457917217934806 no 56 0.00576828774159827 155 6810614 SGTC_1125 tnp00248 1.32998 µM 2.50807062635834 0.00483369274144173 no 57 0.00606962005698206 175 24207736 SGTC_440 fluspirilene 35.1 µM 2.5056327015316 0.00486923503300701 no 58 0.00611162606342021 120 3396 An atypical antipsychotic. SGTC_258 haloperidol 50.781 µM 2.50262478282813 0.00491340808252691 no 59 0.00616380801776794 153 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2151 5563267 85.4165 µM 2.50103314265668 0.00493692642081255 no 60 0.00619157946070941 123 5310824 SGTC_1097 itavastatin 7.23 µM 2.48872938742342 0.00512213896200901 no 61 0.00641002526639934 124 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2627 acetyl isogambogic acid 100 µM 2.48054281793204 0.00524877634789853 no 62 0.00655912536091241 157 6857789 A caspase activator and apoptosis inducer. SGTC_694 1315-0438 43.2 µM 2.47268644026694 0.00537291729182845 no 63 0.00670508725395025 83 6793154 SGTC_1071 trifluoperazine 6.31 µM 2.46656092650264 0.00547151237440305 no 64 0.0068208759311802 121 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2967 9089538 49.85 µM 2.44425080358488 0.00584434066863136 no 65 0.00725766595094353 151 728216 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.43951378622062 0.00592634316272966 no 66 0.00735352074690539 204 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_450 aminopyrene 156 nM 2.41242656926653 0.00641514066337778 no 67 0.00792336458400506 150 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2711 st079103 59.1 µM 2.41102240798047 0.00644142486141873 no 68 0.00795393552178973 92 54693780 SGTC_2292 7671323 168.05 µM 2.38223734946695 0.00700165222981281 no 69 0.00860390120919183 169 937504 SGTC_2003 4023581 200 µM 2.38219137880573 0.00700258029104354 no 70 0.00860497542640481 152 16641307 SGTC_504 lovastatin 124 µM 2.35909486646582 0.00748281278233166 no 71 0.00915978594422952 94 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2780 5215298 71.43 µM 2.34050492616663 0.00789018114085848 no 72 0.00962884217926934 175 2834131 SGTC_2396 5342950 42.78 µM 2.34003096650563 0.00790081737546787 no 73 0.00964107052519278 194 1886677 SGTC_1379 2144-0755 36.5 µM 2.33407529887933 0.0080355485678667 no 74 0.00979588972385694 162 5392327 SGTC_2881 9058953 51.95 µM 2.33056183573327 0.00811597501687803 no 75 0.00988823793000833 169 17122249 SGTC_2556 citropten 84.59 µM 2.3273260283641 0.00819067054978333 no 76 0.00997395973493702 182 2775 A potential DNA crosslinker. SGTC_920 mycophenolic acid 780.421 nM 2.30754207849723 0.0086606343226987 no 77 0.0105123096345717 171 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_820 1582-0060 59.9 µM 2.29987424196944 0.0088490451644648 no 78 0.0107276728893877 166 3848840 SGTC_2771 fluoxetine 41.05 µM 2.28612636594745 0.00919585908672555 no 79 0.0111234334646858 140 3386 A selective serotonin reuptake inhibitor. SGTC_914 3820-6779 408 µM 2.28342738570811 0.00926532562773964 no 80 0.011202602824511 160 2893481 SGTC_942 3253-1115 227 µM 2.27990853547406 0.00935658340692202 no 81 0.0113065568639283 155 46497897 SGTC_680 0417-1641 114 µM 2.27751927981358 0.00941899361842606 no 82 0.0113776173254125 143 2835990 SGTC_645 0845-0943 5.41 µM 2.26949380633749 0.00963130181234671 no 83 0.0116191567238257 134 1885106 SGTC_2359 9039622 200 µM 2.26779188460381 0.00967685869434907 no 84 0.0116709471396927 159 6463596 SGTC_326 k292-0812 17.5 µM 2.23789192442179 0.0105084895396033 no 85 0.0126140518961555 94 3579357 SGTC_708 3448-5400 146 µM 2.23446072800762 0.0106077966701982 no 86 0.0127263868914398 214 3462195 SGTC_262 fenpropimorph 62.5 µM 2.22386193154165 0.010919731760899 no 87 0.0130788675178843 151 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_975 1335-0046 28.5 µM 2.22045967786238 0.0110215422724611 no 88 0.0131937899483402 196 16486740 SGTC_696 1560-0013 611 µM 2.21514062617671 0.0111823664952566 no 89 0.0133752068380647 164 1650269 SGTC_2848 9016370 25.97 µM 2.1987962745206 0.0116893792066725 no 90 0.0139462057655888 177 7894410 SGTC_3339 9145883 14.936 µM 2.19731994772368 0.0117361434816347 no 91 0.0139988019970835 148 2030670 SGTC_762 1165-0429 115 µM 2.19669638069798 0.0117559443757289 no 92 0.014021068765255 157 5967793 SGTC_2351 9026858 72.31 µM 2.19523725056749 0.0118023912672733 no 93 0.0140732917341 170 1409300 SGTC_1980 st071811 45.7 µM 2.19502332951082 0.0118092141484205 no 94 0.0140809621438152 156 4974850 SGTC_1608 st001473 40.5 µM 2.19257580288691 0.0118875204180594 no 95 0.0141689780369942 197 7292267 SGTC_574 1315-0397 40 µM 2.17666195574561 0.012407738146172 no 96 0.0147528994161408 224 6794277 SGTC_2954 9074818 52.69 µM 2.16999869850178 0.012631346293547 no 97 0.0150034722717681 182 16648742 SGTC_2183 6420625 130.508 µM 2.15914478498518 0.0130030553303487 no 98 0.0154194680579795 268 2897619 SGTC_183 3914-0051 30.55 µM 2.15391423797814 0.0131855351766403 no 99 0.0156234490887664 175 1596232 SGTC_2364 9055074 200 µM 2.14772956116782 0.0134041533065734 no 100 0.0158676227878793 170 6470630 SGTC_1661 st013063 9.66 µM 2.14287328292721 0.0135780017525719 no 101 0.0160616374123854 211 721395 SGTC_135 0933-0004 26.348 µM 2.14277775130179 0.0135814410868936 no 102 0.0160654743256985 198 21230617 YGL099W LSG1 SGTC_345 1362-0200 395 µM 2.14104688680712 0.0136438861026058 no 103 0.0161351285949389 175 1419823 SGTC_226 1,3-diallylurea 8.28947 mM 2.13006084347762 0.014046038937311 no 104 0.0165832952561606 156 74537 YKL182W FAS1 SGTC_3309 9129340 25.759 µM 2.12923424201216 0.0140767064155029 no 105 0.0166174426037724 184 17158987 SGTC_62 0180-0423 3.232 µM 2.12730675556483 0.0141484417184615 no 106 0.0166973019112073 181 30102 YGL099W LSG1 SGTC_1769 st044406 64.4 µM 2.12382386098962 0.0142788636646897 no 107 0.0168424374863541 183 670903 SGTC_2820 7989630 71.43 µM 2.12236687115224 0.0143337291535263 no 108 0.0169034709709555 149 2984098 SGTC_2682 pyrogallin 40.03 µM 2.10192676433452 0.0151227839931936 no 109 0.0177798458099446 230 822798 An ATP competetive kinase inhibitor. SGTC_1768 st044301 37.178 µM 2.10145821034729 0.0151413008398049 no 110 0.0178003813525737 187 3931349 SGTC_1293 1000-1278 195 µM 2.09547290863702 0.0153795538229544 no 111 0.0180644871373348 202 678847 SGTC_2971 9092186 9.93 µM 2.08837218653966 0.0156663758431696 no 112 0.0183821372011674 190 25236400 SGTC_1289 0976-0073 69.1 µM 2.08822994676474 0.0156721679587984 no 113 0.0183885485840534 177 3391136 SGTC_3111 9122088 49.47 µM 2.08783272024392 0.0156883530660156 no 114 0.0184064634481266 97 16876704 SGTC_1122 capsaicin 818.572 nM 2.06506743955559 0.0166402017057428 no 115 0.0194583098595899 200 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1694 st024011 44.9 µM 2.0634199260715 0.01671096458142 no 116 0.0195363741946755 217 2787533 SGTC_946 3434-1334 87.4 µM 2.05373006567506 0.0171323875791082 no 117 0.0200009124553346 196 4047976 SGTC_3289 9119912 71.43 µM 2.04874047838348 0.0173529104065942 no 118 0.0202437493983518 214 17014829 SGTC_2778 tioconazole 65.09 nM 2.04748138617796 0.0174089395511213 no 119 0.0203054213201317 279 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1416 3966-0321 25.3 µM 2.04678666181626 0.0174399206163108 no 120 0.0203395179258365 220 582530 YLR208W SEC13 SGTC_473 2-arachidonoylglycerol 10 µM 2.03994961697087 0.0177473365268339 no 121 0.0206776720742879 210 5282280 An endocannabinoid. SGTC_2123 5259487 200 µM 2.03712698887738 0.0178755929774732 no 122 0.0208186589753936 210 2173474 SGTC_813 k007-0158 173 µM 2.03438359952194 0.0180010056618221 no 123 0.020956467066046 255 6523916 SGTC_1932 st074806 40.9 µM 2.03121088350808 0.0181469795707071 no 124 0.0211168034093916 233 17251235 SGTC_1916 st067606 49.2 µM 2.02281516831307 0.018538134873405 no 125 0.0215461036142782 264 19590279 SGTC_2272 7805186 180 µM 2.02001870382034 0.0186700056009668 no 126 0.021690723738951 166 2956062 YPR165W RHO1 SGTC_2152 5568786 200 µM 2.0182681418912 0.0187529611955152 no 127 0.0217816713735017 188 5399883 SGTC_2391 6285546 200 µM 2.01479607879853 0.01891842355893 no 128 0.0219630100417952 256 846083 SGTC_394 menadione 8.33 µM 2.01450957244585 0.0189321324135338 no 129 0.0219780304403763 216 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3128 9127691 49.47 µM 2.01296852494374 0.0190060140248827 no 130 0.0220589703442114 187 41316314 SGTC_2919 7978188 46.38 µM 2.01053076504417 0.0191233869208583 no 131 0.0221875217316815 202 2980291 SGTC_2082 5219693 150 µM 1.99678357787525 0.0197968820936704 no 132 0.0229243491427609 243 2834649 SGTC_596 1155-0152 116 µM 1.99039091657073 0.020116862218894 no 133 0.0232739448677937 290 280313 SGTC_177 1327-0068 8.361 µM 1.98766306040855 0.0202547324038942 no 134 0.0234244834624183 265 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_799 1310-0557 151 µM 1.98688421406978 0.0202942432407646 no 135 0.0234676146807714 236 5354492 SGTC_1785 bathophenanthroline 24 µM 1.97921358812719 0.0206868761456658 no 136 0.0238959818433002 275 72812 An iron chelator. SGTC_1225 1216-0074 20.6 µM 1.96564360878417 0.0213972375346861 no 137 0.0246698964859683 223 4241466 SGTC_987 1497-1013 404 µM 1.95676024784629 0.0218733466475352 no 138 0.0251878313929788 184 1676435 SGTC_1338 1486-1223 76 µM 1.94983270459424 0.0222508134982079 no 139 0.0255980310685257 235 3444526 SGTC_2265 7929201 200 µM 1.94257661184028 0.0226520606504688 no 140 0.0260336675211929 245 1265108 SGTC_1021 4476-0760 85.3 µM 1.94226630693705 0.022669354999624 no 141 0.026052434826714 252 746768 SGTC_2680 butyl paraben 22.24 µM 1.93708048827112 0.0229600294920244 no 142 0.0263677526575083 173 7184 An antifungal and steroid mimetic. SGTC_2541 muurolladie-3-one 83.07 µM 1.933926486488 0.0231383476318115 no 143 0.0265610835255143 239 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_328 k915-0120 63.5 µM 1.93274321768783 0.0232055463442631 no 144 0.02663391919922 238 6624543 SGTC_1748 st037455 53.6035 µM 1.93132975123935 0.0232860334241182 no 145 0.0267211432100013 276 580690 SGTC_1341 1486-1360 280 µM 1.92789151044239 0.0234827987300772 no 146 0.0269343109650752 252 3976547 SGTC_1507 4075-3230 155 µM 1.92283513520246 0.0237747072813717 no 147 0.0272503790148996 169 659771 SGTC_2933 9026794 32.47 µM 1.92036380822026 0.02391848519863 no 148 0.0274059808510711 275 17586027 SGTC_1313 1220-0047 237 µM 1.91900654243768 0.0239977591939183 no 149 0.0274917529346881 299 3528706 SGTC_91 0417-1751 58.384 µM 1.91483431239289 0.0242428308806946 no 150 0.0277568185496462 321 6795624 SGTC_2263 7948595 193.29 µM 1.9142968987256 0.0242745501759527 no 151 0.0277911152413582 179 2971371 SGTC_1711 st032263 62.8 µM 1.90207873829162 0.0250051489259794 no 152 0.0285804308121342 222 3958979 SGTC_458 nppb 133 µM 1.89895601461337 0.0251948059471225 no 153 0.0287851297395241 206 4549 A chloride channel blocker. SGTC_933 2914-0560 114 µM 1.88917221481741 0.0257968414643746 no 154 0.0294343782564024 277 463887 SGTC_1166 k206-0078 225 µM 1.87686544379857 0.0265711765610114 no 155 0.0302682690539344 288 5404595 SGTC_1847 st056231 15 µM 1.8701833347086 0.0269996828338526 no 156 0.0307291815754196 317 5393180 SGTC_15 0266-0086 27.098 µM 1.86569274172884 0.0272908813121778 no 157 0.0310421828741226 353 1712902 YIL048W NEO1 SGTC_3225 9130819 49.47 µM 1.85788407715733 0.027803481666074 no 158 0.0315927390138594 266 4547121 SGTC_1047 2043-3044 82 µM 1.85678096147627 0.0278765383460146 no 159 0.0316711617149106 283 669592 SGTC_245 methotrexate 289.6 µM 1.85662535083189 0.0278868569208713 no 160 0.0316822373225719 309 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_221 trifluoperazine 10.304 µM 1.85658368904129 0.027889620062936 no 161 0.0316852031489698 488 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2011 4012611 177 µM 1.85560979678443 0.027954276692255 no 162 0.0317545981394891 282 2049887 SGTC_1502 4534-4282 27.7 µM 1.84753456080617 0.0284952148516285 no 163 0.0323348519829782 214 3278949 SGTC_3034 9090421 49.47 µM 1.84613684608384 0.0285897223972627 no 164 0.0324361690063246 212 17173761 SGTC_332 4112-0506 40.9 µM 1.8444682507427 0.0287028869909857 no 165 0.0325574643510003 246 2790355 SGTC_160 3453-0671 289.699 µM 1.83860740875324 0.0291033266403034 no 166 0.0329864753925548 292 5322268 SGTC_568 1193-0097 7.48 µM 1.83359752269813 0.0294492945518115 no 167 0.0333568801195849 396 3646150 SGTC_2930 9013230 14.89 µM 1.8300213851063 0.0296983349784348 no 168 0.0336233705664448 320 2995857 SGTC_2811 7967822 32.47 µM 1.82768885656427 0.0298617108401301 no 169 0.0337981307476818 279 2232244 SGTC_315 k915-0449 187 µM 1.82721516267433 0.0298949803992831 no 170 0.0338337124802551 343 20970215 YNL149C PGA2 SGTC_3199 9111318 49.47 µM 1.82693642030718 0.0299145720389278 no 171 0.0338546647386618 277 8548020 SGTC_2729 fluphenazine 10.66 µM 1.82647206850793 0.029947233037917 no 172 0.03388959242231 291 3372 An atypical antipsychotic. SGTC_329 k048-0121 21.3 µM 1.82520953198943 0.0300361853064576 no 173 0.0339847079652589 260 6832902 SGTC_1012 4112-3522 18 µM 1.82469906933922 0.0300722121998038 no 174 0.0340232268973907 287 3112398 SGTC_1903 st060211 78.3 µM 1.82233874939109 0.030239262516411 no 175 0.0342018010365135 308 688960 SGTC_2624 nerol 100 µM 1.82151345168831 0.0302978536748936 no 176 0.0342644218901493 233 637566 A natural product oil. SGTC_2863 9028737 58.44 µM 1.82145460088363 0.0303020353181626 no 177 0.0342688908913792 204 6460917 SGTC_891 0929-0073 133 µM 1.81115670805568 0.0310411510273714 no 178 0.0350582987222345 248 5603632 SGTC_798 1287-0182 476 µM 1.80684250043674 0.0313551998430045 no 179 0.0353934199692146 321 1649755 SGTC_1564 D-Arginine 115 µM 1.8055270278986 0.031451479520176 no 180 0.0354961250053846 301 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1550 gossypolone 36.6 µM 1.80354114390778 0.0315972896194527 no 181 0.0356516349424266 314 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2124 5246320 200 µM 1.79323390083107 0.0323630827924532 no 182 0.0364677657575735 286 579342 SGTC_2362 9071156 126 µM 1.78940587090175 0.0326513647271559 no 183 0.0367747372607558 290 653133 SGTC_582 0987-0078 156 µM 1.77951943499849 0.0334057026387438 no 184 0.0375773207358928 430 1625765 SGTC_3076 9116187 49.47 µM 1.77738574824364 0.0335703720792559 no 185 0.0377523970045806 264 27241210 SGTC_637 1181-0519 7.26 µM 1.77650846440265 0.0336382709012547 no 186 0.037824574017644 422 6252091 YGR060W ERG25 SGTC_2093 5331342 194.4 µM 1.77565200090502 0.0337046672891658 no 187 0.0378951466718329 290 33839 SGTC_187 1488-2104 32.728 µM 1.77551369699205 0.0337153992541797 no 188 0.0379065529939507 310 2852859 SGTC_428 3448-4153 16.5 µM 1.77433551169473 0.0338069369189704 no 189 0.0380038349539161 280 3834874 SGTC_395 anisomycin 6.25 µM 1.77369668380835 0.0338566552956665 no 190 0.0380566676379755 228 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3048 9093155 49.47 µM 1.76923609553783 0.0342054903905322 no 191 0.038427241428648 232 25236002 SGTC_2523 spermine 47.74 µM 1.76802112896554 0.0343010157403809 no 192 0.0385286857263291 274 1103 A DNA binding polyamine. SGTC_1696 st025591 34.7925 µM 1.75212704670154 0.0355709852984801 no 193 0.0398759822454901 329 2787147 SGTC_547 1120-0019 610 nM 1.75039608618237 0.0357115905607353 no 194 0.0400249954517446 321 3676939 SGTC_2935 9038016 29.96 µM 1.74914093707293 0.0358138304710848 no 195 0.0401333302414273 319 6463195 SGTC_2069 5228469 200 µM 1.74804128178385 0.0359036014098713 no 196 0.0402284396761041 278 2835210 SGTC_1524 corynanthine 62.1 µM 1.74635759557458 0.0360414071464349 no 197 0.0403744167543249 303 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_703 3875-0075 71.8 µM 1.74093435650378 0.0364882340116187 no 198 0.0408475428087045 261 2850814 SGTC_1421 4029-0249 71.4 µM 1.74073111410746 0.0365050671117722 no 199 0.040865360850026 330 2894095 SGTC_2154 5570129 200 µM 1.73245759839704 0.0371957148799821 no 200 0.0415960601718653 330 673366 SGTC_3014 9081533 49.47 µM 1.72753518368998 0.037611664264385 no 201 0.0420357960217582 300 21367265 SGTC_383 2324-0395 7.37 µM 1.7272824702614 0.037633120902105 no 202 0.0420584729265766 333 3146421 SGTC_2716 st080858 38.6235 µM 1.7229299159379 0.0380042454065528 no 203 0.0424505998181433 278 5296050 SGTC_2478 5763493 32.33 µM 1.72171373350542 0.0381084763417519 no 204 0.0425606941358397 302 1365576 YLR208W SEC13 SGTC_1332 1480-0653 17.5 µM 1.72096117932967 0.0381730894682176 no 205 0.0426289342913514 310 5749438 SGTC_1400 3771-8998 51.5 µM 1.7185404536486 0.0383815353455893 no 206 0.0428490411504836 271 670767 SGTC_584 0986-0246 15.4 µM 1.71740712894685 0.0384794430270086 no 207 0.0429524050124169 336 53315 YDR232W HEM1 SGTC_1804 st050076 49.1 µM 1.71386002415264 0.0387871929351615 no 208 0.0432772181968485 307 3895976 SGTC_218 alverine citrate 93.75 µM 1.70978456965841 0.0391432548718438 no 209 0.0436528586958669 280 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_273 hydroxyurea 18.1 mM 1.70304941027038 0.0397375165352386 no 210 0.0442794110662037 384 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2283 7944793 200 µM 1.69500962632108 0.0404564709078216 no 211 0.0450367973350327 349 2970533 SGTC_167 3672-0051 66.205 µM 1.69073893613142 0.0408426495607679 no 212 0.0454433371820359 318 3237971 SGTC_1978 st071761 42 µM 1.69013897141942 0.0408971403802962 no 213 0.0455006853218049 307 5147680 SGTC_1041 0206-0046 107 µM 1.68942444998532 0.0409621125535095 no 214 0.0455690593731952 318 50494 SGTC_3177 9107506 49.47 µM 1.67868999617244 0.0419483221139392 no 215 0.0466062383108664 256 8897194 SGTC_1738 st035555 74 µM 1.67709015187689 0.0420969375829663 no 216 0.0467624271368651 369 5331140 SGTC_2736 butenafine 14.65 µM 1.67592433634221 0.0422055026890833 no 217 0.0468765070791133 382 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2774 tamoxifen 10.92 µM 1.67345701702356 0.0424360158378757 no 218 0.0471186807307115 324 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2662 daunorubicin 22.37 µM 1.67187428066382 0.0425844208225924 no 219 0.0472745576893471 293 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2256 7954252 200 µM 1.66911366384496 0.0428442736744947 no 220 0.0475474279369072 254 2972920 SGTC_721 1187-1332 279 µM 1.66860392714475 0.0428923943197433 no 221 0.0475979500419823 232 25730 SGTC_3001 9076041 71.4286 µM 1.66653985946518 0.0430876950613204 no 222 0.0478029680234565 312 16004211 SGTC_3313 9133968 57.047 µM 1.6584205572295 0.0438629191838854 no 223 0.0486163050642818 354 1494643 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.65615307123668 0.0440814150350756 no 224 0.0488454120436432 434 551469 SGTC_409 arachidonic acid 100 µM 1.64493218483915 0.0451756128435444 no 225 0.049991898405396 345 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1636 st007707 68.9 µM 1.64431706135275 0.0452362224956451 no 226 0.0500553634614948 392 403051 SGTC_1722 st034304 3.6505 µM 1.63501805486585 0.046160471052227 no 227 0.0510226314044882 381 4036148 YLR033W RSC58 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.63370500188628 0.0462921916775914 no 228 0.0511604037988929 384 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_405 ebelactone b 50 µM 1.62621919211711 0.0470489154377433 no 229 0.0519515174145581 372 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2172 5754775 163.918 µM 1.62575761726139 0.0470958977477778 no 230 0.0520006138570089 353 2263357 SGTC_754 3474-0146 171 µM 1.62008594302169 0.0476762763471272 no 231 0.052606908294182 340 24762078 SGTC_3249 9135183 49.47 µM 1.61828958585495 0.0478612861250511 no 232 0.0528001019866539 368 4902779 SGTC_1473 k844-0725 134 µM 1.61437375977386 0.0482665755775002 no 233 0.0532231899248042 396 54682906 SGTC_120 rhodamine 6G 52.259 µM 1.61389071856491 0.0483167601904323 no 234 0.0532755661100714 458 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_890 0929-0006 47.2 µM 1.60825145160343 0.0489057338615689 no 235 0.0538900593481855 328 1378169 SGTC_2752 diclazuril 33.15 µM 1.60691339562744 0.0490463211784419 no 236 0.0540366837219564 540 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2918 7977171 22.06 µM 1.59459984017359 0.0503552930709763 no 237 0.0554008741880914 348 2236483 SGTC_272 doxorubicin 8.13 µM 1.5944384508551 0.0503726323333176 no 238 0.0554189330294184 422 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1296 1068-0102 11.9 µM 1.59343942591867 0.0504800709638304 no 239 0.055530823516714 365 767053 SGTC_2406 ethylparaben 405.7 µM 1.58998638566644 0.0508528296732844 no 240 0.0559189369287391 336 8434 A possible steroid mimic. SGTC_1679 SEC14.276 6.7 µM 1.58315857719695 0.0515963464528381 no 241 0.0566926625585192 456 1005053 YMR079W SEC14 SGTC_425 3825-7017 13.1 µM 1.57838648130036 0.052121118233617 no 242 0.0572384244983793 413 3397440 SGTC_1850 st056238 17 µM 1.57668094296933 0.0523096958357538 no 243 0.0574344787504712 423 5393177 SGTC_2730 imipramine 71.33 µM 1.56496012958448 0.0536203349762189 no 244 0.0587961291202267 465 3696 A tricyclic antidepressant. SGTC_1346 1488-2224 62.4 µM 1.55718994738242 0.0545034540548383 no 245 0.0597126971903027 387 3722427 SGTC_254 nsc-64875 3.808 µM 1.5559864924715 0.0546412555676073 no 246 0.0598556521911029 374 56993 SGTC_862 0452-0056 10.2 µM 1.55565284752173 0.0546795082908889 no 247 0.0598953323566129 360 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_31 0508-1974 57.237 µM 1.55338039630518 0.0549406105588157 no 248 0.0601661417333875 379 6810525 SGTC_1172 0370-0043 85 µM 1.55311302267097 0.054971396185762 no 249 0.0601980677377026 358 376585 SGTC_1382 3002-2117 298 µM 1.55204809704212 0.0550941479163752 no 250 0.0603253578181211 406 1497314 SGTC_1447 4239-0816 81.9 µM 1.55176777747838 0.0551264957391092 no 251 0.0603588992886681 373 1341554 SGTC_1720 st037298 9.481 µM 1.54948744182002 0.0553901956684151 no 252 0.0606322940352251 382 597396 SGTC_2722 naftopidil 47.16 µM 1.54917209123476 0.0554267413408418 no 253 0.0606701782716041 390 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_772 k072-0172 35.3 µM 1.54755450110857 0.0556145016685744 no 254 0.0608647965152732 354 5861980 SGTC_2107 5363541 170.161 µM 1.54739947736884 0.055632522240747 no 255 0.0608834735973867 397 244052 SGTC_1251 0490-5699 265 µM 1.54492145404182 0.0559212035316452 no 256 0.061182631700182 459 3883818 SGTC_2006 4011487 200 µM 1.54260136879245 0.0561925554773166 no 257 0.061463762864888 455 45595294 SGTC_292 k038-0015 474 µM 1.54235043855688 0.0562219658216244 no 258 0.0614942291439737 365 46368540 SGTC_1196 1588-0294 184 µM 1.53496402975028 0.0570931406011054 no 259 0.062396331938138 369 6144269 SGTC_2581 avocatin a 64 µM 1.53152127746371 0.0575028030741769 no 260 0.0628203059371499 456 6710728 A skin care supplement. SGTC_2583 asiatic acid 100 µM 1.52602236048438 0.0581619261438228 no 261 0.0635021479329043 374 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1195 1502-0147 41.1 µM 1.51231338041896 0.059830992476495 no 262 0.0652270793580832 436 817940 SGTC_783 0848-0141 92.7 µM 1.50439747120073 0.0608117044273299 no 263 0.0662395275095756 388 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1279 0874-0590 65.2 µM 1.50310648022071 0.0609728324544302 no 264 0.066405794015134 423 3523074 SGTC_1997 st073024 93.8 µM 1.49525906655627 0.0619594555653064 no 265 0.067423421763709 398 686268 SGTC_670 4204-0025 119 µM 1.49425132601939 0.0620870522525808 no 266 0.0675549709710863 457 719039 SGTC_2448 5185112 27.17 µM 1.49247094017455 0.0623129796073137 no 267 0.0677878649395229 385 5718189 SGTC_2008 4012253 172 µM 1.49192646303038 0.0623822005262806 no 268 0.0678592122012456 457 603940 SGTC_24 0417-1663 219 µM 1.49129532084608 0.0624625144387478 no 269 0.0679419884466937 419 4329390 SGTC_1074 carmofur 3.8 µM 1.48620684925577 0.0631129794027224 no 270 0.0686122082143114 477 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2512 diallyl trisulfide 49.23 µM 1.48042846173102 0.0638580203890362 no 271 0.0693794695369651 363 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1901 st060216 58.6 µM 1.48018050415445 0.0638901434084671 no 272 0.0694125409236536 434 688792 SGTC_2480 5767542 37.17 µM 1.47478705405658 0.0645919814353863 no 273 0.0701349014031263 410 2867358 SGTC_3331 9141060 1.957 µM 1.47435350445661 0.0646486573345176 no 274 0.0701932181280369 420 4906567 YPR165W RHO1 SGTC_1401 3807-4679 7.6 µM 1.47322854949142 0.0647958975380003 no 275 0.0703447096732012 394 3291456 SGTC_1277 0873-0036 22 µM 1.47215775467066 0.0649362907258364 no 276 0.0704891411862967 484 5965735 SGTC_3118 9124250 49.47 µM 1.47102895698038 0.0650845442890456 no 277 0.0706416429834494 390 1504786 SGTC_665 3914-0008 307 µM 1.47008803147554 0.0652083237988172 no 278 0.0707689567112225 441 1069549 SGTC_1242 0402-0103 60.1 µM 1.46596114275663 0.0657533778480882 no 279 0.0713294365420021 418 432868 SGTC_1666 st014829 29 µM 1.46534478573355 0.0658350847205832 no 280 0.0714134366897488 468 3858230 SGTC_2451 5856223 45.7 µM 1.46338045429838 0.0660960098252919 no 281 0.0716816519690924 428 2179896 SGTC_1900 st060200 72.8 µM 1.46266179042733 0.0661916709454253 no 282 0.0717799731860242 435 688945 SGTC_1049 3226-0134 66 µM 1.46033402426739 0.0665022554736597 no 283 0.0720991476983301 483 5702385 SGTC_1617 st002906 78 µM 1.45882782235148 0.0667038223635343 no 284 0.072306251435086 469 5150859 SGTC_210 3551-0445 56.827 µM 1.45701648055043 0.0669468502700868 no 285 0.0725559155057646 454 2865180 YOR207C RET1 SGTC_3224 9130643 49.47 µM 1.45688849613412 0.0669640478249098 no 286 0.0725735810254595 441 17644395 SGTC_1098 clofazimine 15.1 µM 1.45476528616561 0.0672498471713853 no 287 0.0728671257664583 501 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1778 st046819 58.9 µM 1.45407060890609 0.0673435601975806 no 288 0.0729633655737304 518 671715 SGTC_3337 9144342 33.5465 µM 1.45173400052629 0.0676595131596844 no 289 0.0732877907450169 438 17682949 SGTC_1801 st050089 28.441 µM 1.44789286763276 0.0681813929514356 no 290 0.0738235073364175 573 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1144 3486-0183 12.5 µM 1.4470478757793 0.0682966145580805 no 291 0.0739417575989265 473 6744069 SGTC_153 4077-0274 519.67 µM 1.44670384353281 0.0683435692122139 no 292 0.073989943765935 416 3121976 SGTC_366 0181-0206 4.31 µM 1.44390349895466 0.0687266965509919 no 293 0.0743830611379283 479 274874 SGTC_1115 galangin 695.678 nM 1.44338620695813 0.0687976504002834 no 294 0.0744558536980187 489 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_100 0086-0128 49.5915 µM 1.44325624018755 0.0688154860395483 no 295 0.0744741509740358 518 93297 SGTC_3173 9105693 49.47 µM 1.44280860969878 0.0688769426872196 no 296 0.0745371965741769 479 17096658 SGTC_1659 st012954 42.1 µM 1.44171320672232 0.0690275125838468 no 297 0.0746916481846872 423 24207262 SGTC_68 0986-0284 82.829 µM 1.44136600585283 0.0690752903949441 no 298 0.0747406543807829 442 423278 YIL048W NEO1 SGTC_866 0495-0101 262 µM 1.44069196810036 0.0691681165154483 no 299 0.0748358625108894 423 635694 SGTC_3327 9140648 26.9345 µM 1.43425024422284 0.0700601031860541 no 300 0.0757504317578241 439 8029710 SGTC_756 0508-1999 28.3 µM 1.43321530130308 0.0702042333495711 no 301 0.0758981590917512 444 6753853 SGTC_1423 4048-0112 5.59 µM 1.42997520210455 0.0706569369045477 no 302 0.0763620682106758 460 X1423 SGTC_2508 celastrol 40.54 µM 1.42693049469047 0.0710843819426066 no 303 0.0767999649759354 403 122724 Celastrol is a natural product and antioxidant. SGTC_1668 st014914 51.6 µM 1.42314704787525 0.0716183018852433 no 304 0.077346766045415 419 2839556 SGTC_3328 9140624 29.0385 µM 1.42146137507987 0.071857172506128 no 305 0.0775913373745567 464 4904392 SGTC_1223 0764-0573 147 µM 1.41902910354512 0.0722029171775892 no 306 0.0779452656692562 511 1609797 SGTC_233 rapamycin 362 pM 1.41850621609999 0.0722774112844445 no 307 0.0780215125779453 459 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3017 9080681 49.47 µM 1.41465243297553 0.0728282653964942 no 308 0.0785852136928668 449 16451914 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.41125619170695 0.0733163785157335 no 309 0.0790845433889357 456 6710655 SGTC_317 4495-0002 170 µM 1.41102583789214 0.0733495757325842 no 310 0.0791184977886435 421 15991618 SGTC_2793 7325131 81.82 µM 1.40938414513339 0.0735864997455589 no 311 0.0793608048274202 423 4176441 SGTC_1362 1611-0397 101 µM 1.40820439712959 0.073757118325911 no 312 0.0795352773059887 481 27816 SGTC_2772 vinpocetine 57.06 µM 1.40144184163379 0.0747409785062413 no 313 0.0805409937569133 467 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2659 sanguinarine 24.21 µM 1.39715496436466 0.0753698275766519 no 314 0.0811834881099214 476 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1684 st024538 14.6195 µM 1.39580101000455 0.0755692770693989 no 315 0.0813872130804362 484 6732859 SGTC_1358 1509-0022 2.48 µM 1.3950610355038 0.0756784517016111 no 316 0.0814987174017067 490 3258434 SGTC_2200 6600604 21.907 µM 1.39466172088493 0.075737415822824 no 317 0.0815589366454964 509 2904777 SGTC_2792 7535235 81.82 µM 1.39236121687685 0.0760777976296797 no 318 0.0819065212422937 457 1281891 SGTC_1828 st055811 49 µM 1.39041393913854 0.0763668252125952 no 319 0.0822016080460626 418 5877589 SGTC_3075 9116269 49.47 µM 1.39037676965481 0.0763723502630997 no 320 0.082207248417611 485 17015205 YNL244C SUI1 SGTC_116 0155-0182 31.788 µM 1.38834146535852 0.0766753521924928 no 321 0.0825165456917701 631 771486 SGTC_1489 4065-0444 182 µM 1.38792365686356 0.0767376655547345 no 322 0.0825801466572954 471 2877968 SGTC_3004 9076122 71.4286 µM 1.38429807444425 0.0772800149916733 no 323 0.0831336017011295 502 44782551 SGTC_1765 st044815 90.4 µM 1.38085560862858 0.0777976624340213 no 324 0.0836616806811895 485 645695 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.37644209917538 0.0784651714701791 no 325 0.0843424008523382 487 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2017 5132927 60.65 µM 1.37618005464954 0.0785049397994809 no 326 0.0843829477720281 502 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1359 1582-0056 520 nM 1.37551142570752 0.0786064813113403 no 327 0.084486472965015 547 3661189 SGTC_2784 7567673 72.73 µM 1.37386908639816 0.0788563181222008 no 328 0.0847411641646136 533 3471247 SGTC_1719 st032227 49.2 µM 1.37338644865582 0.0789298524468776 no 329 0.0848161201597575 491 3125804 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.37259993904879 0.0790497957380953 no 330 0.0849383754341531 536 688664 SGTC_827 3253-0474 693 µM 1.36956931474055 0.0795132591223716 no 331 0.085410691879532 525 5402065 SGTC_1440 4100-1550 40 µM 1.36806538784391 0.0797440117172782 no 332 0.085645804815174 435 742806 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.36747109311722 0.0798353358744569 no 333 0.0857388459652247 530 6728940 SGTC_2236 dapsone 200 µM 1.36538281733122 0.0801568646568332 no 334 0.0860663807734465 512 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2245 6637752 200 µM 1.36530635017924 0.0801686567428307 no 335 0.0860783919766376 412 681890 SGTC_1908 st060353 56.5 µM 1.36524908344983 0.0801774887686354 no 336 0.0860873880632452 561 4227716 SGTC_3351 9150312 21.596 µM 1.36200760572878 0.0806786091857819 no 337 0.0865977424209881 516 4904905 SGTC_1263 0774-1208 64.8 µM 1.36028788641444 0.0809454299298505 no 338 0.0868694200961195 596 906585 SGTC_2341 7987486 176.74 µM 1.35985406374017 0.0810128441996166 no 339 0.0869380549727204 543 1258686 SGTC_1952 st077036 64.1 µM 1.35815027813561 0.0812780155811597 no 340 0.0872080020688335 524 2937007 SGTC_1817 st052116 64.4 µM 1.35656060867588 0.0815260163110183 no 341 0.0874604325887653 484 4361398 SGTC_404 fumagillin 50 µM 1.35525527087498 0.0817300854189779 no 342 0.0876681202854793 534 12015870 A methionine aminopeptidase binder. SGTC_2431 5490079 200 µM 1.3551875506341 0.0817406829143794 no 343 0.0876789050456809 516 5722345 SGTC_904 1141-0088 396 µM 1.35483195764272 0.0817963464248632 no 344 0.0877355511120973 503 1378119 SGTC_1025 k007-0731 70 µM 1.3530562582532 0.0820747369637533 no 345 0.0880188291550064 481 6256118 SGTC_1740 st038286 13.222 µM 1.3500162720572 0.0825529960028797 no 346 0.0885053816993903 513 716786 SGTC_2305 7443522 69.23 µM 1.34885700323191 0.0827359268700968 no 347 0.0886914505287519 529 5415886 SGTC_2415 st077333 57.7 µM 1.34870854988127 0.0827593745993908 no 348 0.0887152991105025 595 2766255 SGTC_3183 9108214 49.47 µM 1.34866498650568 0.0827662562433397 no 349 0.0887222983412891 355 4974831 SGTC_822 1487-0950 154 µM 1.34866449776534 0.0827663334513929 no 350 0.088722376868447 492 1958375 SGTC_2634 4'-methoxyflavone 100 µM 1.34807713634086 0.0828591602028465 no 351 0.0888167871416356 475 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_740 k014-0057 261 µM 1.34710443429406 0.0830130585163969 no 352 0.0889733001067525 572 4012779 SGTC_192 3455-0609 60.9 µM 1.34484168532174 0.0833718962480231 no 353 0.0893381826905556 505 3769639 SGTC_1678 st019265 80.2 µM 1.34128716952637 0.0839379411962757 no 354 0.0899136169508126 558 5367020 SGTC_3244 9134489 49.47 µM 1.34113302031478 0.0839625540821981 no 355 0.0899386340672476 508 16584271 SGTC_1311 1190-0148 100 µM 1.33829810601096 0.0844161694866983 no 356 0.0903996394990785 622 1961333 SGTC_2997 9067075 71.4286 µM 1.33723741397142 0.0845863629856421 no 357 0.0905725764453348 564 27209819 SGTC_1993 st073995 70.8 µM 1.33596111198647 0.0847914932308359 no 358 0.0907809921835932 514 3098394 SGTC_2060 5238662 140 µM 1.33514912005245 0.0849221924840787 no 359 0.0909137727861122 501 790130 SGTC_41 0478-0632 82.643 µM 1.3350314061333 0.0849411523934605 no 360 0.0909330338516512 610 3750424 SGTC_836 0330-0104 1.35 µM 1.33498955639666 0.084947893798545 no 361 0.0909398822888376 510 46494820 SGTC_2691 st077356 60.2 µM 1.3348619073673 0.0849684587426181 no 362 0.0909607735856585 527 2839272 SGTC_1476 4112-3294 3.34 µM 1.33436021263899 0.0850493206151182 no 363 0.0910429164482476 503 704369 SGTC_1153 4055-0057 267 µM 1.33325959614061 0.0852269171997298 no 364 0.0912233139628627 525 882706 SGTC_1200 1643-0193 18.4 µM 1.33042416631428 0.0856857248212099 no 365 0.0916892783210412 562 5403974 SGTC_1664 st014217 9.02 µM 1.32756121678527 0.0861508591000631 no 366 0.0921615519866639 548 3982782 SGTC_2235 salicylic acid 500 µM 1.32541355943273 0.0865010201400121 no 367 0.0925170110680284 504 338 A COX inhibitor and kinase inhibitor. SGTC_1771 st048882 4.1505 µM 1.32401556692621 0.0867295244326244 no 368 0.0927489373924188 525 4580403 SGTC_3284 9108171 64.8615 µM 1.32317255451744 0.086867534120588 no 369 0.0928890004241512 488 8687505 SGTC_2669 eugenol 100 µM 1.30943306056327 0.0891400120977976 no 370 0.0951938493787871 462 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2020 4017018 200 µM 1.30939585045292 0.0891462260584233 no 371 0.0952001481770708 537 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_3194 9111903 49.47 µM 1.30553580530257 0.0897925929139035 no 372 0.0958552316198603 541 17087251 SGTC_662 k832-1615 104 µM 1.30546108142901 0.0898051397525407 no 373 0.0958679455468722 534 5878478 SGTC_988 1497-1057 103 µM 1.30499573788322 0.0898833046238774 no 374 0.095947149547729 535 3533044 SGTC_172 1112-0046 2.638 µM 1.30445251401246 0.0899746151926494 no 375 0.0960396700691381 480 2802135 YIL048W NEO1 SGTC_452 diindolylmethane 8 µM 1.30246027749589 0.0903100804617777 no 376 0.0963795442384641 472 3071 Inhibits expression of several cancer promoting factors. SGTC_1654 st012436 41.8 µM 1.30132095341304 0.0905023440291901 no 377 0.0965743089792776 497 4323132 SGTC_957 1187-1561 14.1 µM 1.29624395510023 0.0913627943801871 no 378 0.0974457252237659 566 1538454 SGTC_2021 4019055 173 µM 1.29528646811871 0.0915257468833993 no 379 0.0976107127505125 716 44827708 YER133W GLC7 SGTC_2156 5649887 115 µM 1.2947486460849 0.0916173719970905 no 380 0.0977034763162035 650 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1615 st002656 86.5 µM 1.29268641648831 0.091969330129431 no 381 0.0980597688315285 542 1584458 SGTC_773 4358-1457 44.6 µM 1.29244071498478 0.0920113303591703 no 382 0.0981022822001244 614 1186886 SGTC_1602 st001878 87.6 µM 1.29213030564206 0.0920644120546047 no 383 0.0981560111755819 535 595405 YLR310C CDC25 SGTC_2687 chenodiol 100 µM 1.2892103801271 0.092564845484614 no 384 0.0986624786588205 523 5702181 A cholesterol synthesis inhibitor. SGTC_74 000s-0487 160.283 µM 1.28875367384403 0.0926433000456602 no 385 0.0987418680397004 550 677548 SGTC_2199 6590217 200 µM 1.28801072156539 0.0927710319863566 no 386 0.0988711155115461 464 703109 SGTC_1977 st070720 65.3 µM 1.27993800564049 0.0941673367586351 no 387 0.100283469935794 506 682188 SGTC_3215 9129942 49.47 µM 1.27903345000932 0.0943247548648051 no 388 0.100442638442634 509 17682944 SGTC_2642 cholecalciferol 100 µM 1.27506890919022 0.0950169860951086 no 389 0.101142426379002 519 9821465 A vitamin D precursor, similar to steriods. SGTC_2114 5491910 81.25 µM 1.27130693214441 0.095677301939596 no 390 0.101809738577804 567 2849228 SGTC_1260 0700-1617 7.75 µM 1.26939045780469 0.0960149837514594 no 391 0.102150918903855 608 2853078 SGTC_523 1934-0222 13.7 µM 1.26874106144363 0.0961296056227856 no 392 0.102266716149858 571 1361595 SGTC_119 0121-0043 24.815 µM 1.2678500937085 0.0962870297597969 no 393 0.102425744559892 741 1092378 SGTC_1630 st005209 31.3 µM 1.26548408410073 0.0967059970101065 no 394 0.10284892512508 639 3367314 SGTC_2561 acetosyringone 100 µM 1.26350696963124 0.0970571252852262 no 395 0.103203521729472 649 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1340 1486-1359 257 µM 1.26266142226276 0.0972075767387297 no 396 0.103355441845842 581 4309068 SGTC_746 1095-0025 46.6 µM 1.26161116435765 0.0973946913293016 no 397 0.103544368434445 605 6749286 SGTC_2284 7945075 39.21 µM 1.25885912886851 0.0978862486330055 no 398 0.104040609304901 646 1245402 SGTC_1375 2910-0797 186 µM 1.25508368797876 0.0985635573642168 no 399 0.104724190674363 571 742508 SGTC_2606 farnesol 9.78 µM 1.25473383665855 0.0986264934585283 no 400 0.10478769904598 586 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_614 0462-0418 107 µM 1.25310557039987 0.0989197955872426 no 401 0.105083644541707 514 5188303 SGTC_668 1682-0499 62.6 µM 1.25106479863548 0.0992883034463528 no 402 0.105455418578538 634 682214 SGTC_2111 5486399 200 µM 1.2501684060635 0.0994504844409702 no 403 0.105619017690825 643 689674 SGTC_2900 5328528 85.29 µM 1.2501447184178 0.0994547727836448 no 404 0.105623343370963 623 795359 SGTC_89 0302-0250 142.109 µM 1.25008366160465 0.099465826955199 no 405 0.10563449375028 640 4203518 YLR208W SEC13 SGTC_2046 4110841 106 µM 1.2495117021191 0.0995694222910901 no 406 0.105738988048881 578 44119630 YMR134W ERG29 SGTC_1148 3909-7663 27.7 µM 1.24942137178935 0.0995857904487064 no 407 0.105755497804158 586 4084526 SGTC_7 0192-1582 4.227 µM 1.24871912301088 0.0997131073420482 no 408 0.105883912002403 696 252616 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.24824491325257 0.0997991482635533 no 409 0.105970690385599 556 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_10 0279-0212 42.575 µM 1.24463567741641 0.100455788105008 no 410 0.106632849851217 696 39851 YBR002C RER2 SGTC_1969 st069479 40.1 µM 1.242645583628 0.100819197801104 no 411 0.106999232250415 527 3895485 SGTC_1072 oxiconazole 14.9 nM 1.2407984357162 0.101157361218767 no 412 0.107340109632182 620 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3268 9137683 49.47 µM 1.2312213672127 0.102923924848851 no 413 0.10912004096898 543 1953228 SGTC_73 0327-0325 16.231 µM 1.23084674745805 0.102993478991669 no 414 0.10919009386181 680 53298 SGTC_2419 paclitaxel 166.5 µM 1.23077878333705 0.1030061012749 no 415 0.109202806433095 657 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2537 larixol 68.93 µM 1.23058108474821 0.103042824206328 no 416 0.109239791658142 655 6708759 SGTC_2191 5911152 200 µM 1.22498228061374 0.104086765085316 no 417 0.110290948410754 584 2875902 SGTC_1492 4158-0558 28.5 µM 1.22314526443762 0.104430956239751 no 418 0.110637417417555 577 3967268 SGTC_2839 9003951 25.97 µM 1.22192656812101 0.104659750937579 no 419 0.11086769867897 565 2990634 SGTC_856 0433-0016 11.3 µM 1.22172666576007 0.104697314691619 no 420 0.110905504397639 619 3911780 SGTC_3302 9125395 16.351 µM 1.21708024193804 0.105573179341272 no 421 0.11178684366506 603 17599668 SGTC_2488 5268135 45.7 µM 1.21667783915599 0.105649282028698 no 422 0.111863406953815 698 1270356 YLR208W SEC13 SGTC_744 1594-0068 283 µM 1.21636841469243 0.105707827564083 no 423 0.111922305194005 670 668392 SGTC_1955 wogonin 32.4 µM 1.21600730372975 0.105776182245475 no 424 0.111991069878192 578 5281703 A flavanone. SGTC_2604 4'-hydroxychalcone 11.32 µM 1.21496690562535 0.105973297792472 no 425 0.112189356932314 569 5282362 SGTC_2128 5255449 168.493 µM 1.20813275184211 0.107274708898891 no 426 0.113498101771163 643 736008 SGTC_2769 toremifene 3.73 µM 1.20575022973523 0.107731104400863 no 427 0.113956905543802 582 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1812 st052057 4.327 µM 1.20547038731629 0.107784802623857 no 428 0.114010881571448 635 3645418 SGTC_885 0865-0106 16.8 µM 1.20370432774596 0.108124131943613 no 429 0.114351939481419 613 2793380 SGTC_739 1486-1183 203 µM 1.19914940234012 0.109002859715269 no 430 0.115234928732488 639 4346692 SGTC_3190 9110366 49.47 µM 1.19535577748203 0.109738627347045 no 431 0.11597402790677 525 17123768 SGTC_3235 9132602 49.47 µM 1.1885610727455 0.111065347751338 no 432 0.117306216869826 659 4912240 SGTC_2073 5212005 126 µM 1.18786182465643 0.111202530655185 no 433 0.117443926019645 526 691789 SGTC_1363 1636-0063 10.4 µM 1.18582727686742 0.111602370999521 no 434 0.117845258575483 667 6072185 SGTC_3051 9093778 49.47 µM 1.18329969103838 0.112100537214131 no 435 0.118345197609368 554 17217378 SGTC_1365 1672-3266 55.4 µM 1.18302973455787 0.112153837205334 no 436 0.118398681626385 680 6415873 SGTC_1864 st057645 30.4 µM 1.18225178486969 0.112307536277424 no 437 0.118552905264958 602 688666 SGTC_148 3253-0744 288.01 µM 1.18196312173716 0.112364605555676 no 438 0.118610167013119 609 6893655 SGTC_178 4092-0806 87.505 µM 1.17769562090329 0.113210717448157 no 439 0.119458986666718 711 2169044 SGTC_3338 9144300 39.5675 µM 1.17693749898698 0.113361503546539 no 440 0.119610226752628 653 4901274 SGTC_2205 7238770 200 µM 1.17600008317128 0.113548148167688 no 441 0.119797421411109 610 279867 SGTC_945 3381-0768 11.3 µM 1.17564170869665 0.113619560351037 no 442 0.119869040564054 677 1126236 YIL048W NEO1 SGTC_2171 5739187 198.077 µM 1.17420886876823 0.113905397886252 no 443 0.120155687279265 565 2262761 SGTC_682 0kpi-0099 17 µM 1.17204709780684 0.114337619133556 no 444 0.120589073788882 681 1714895 YML126C ERG13 SGTC_2617 dihydrotanshinone i 20.83 µM 1.1708741410085 0.114572626472742 no 445 0.120824685348375 678 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_922 1866-0035 480 µM 1.17086648667081 0.114574161183014 no 446 0.120826223936704 744 3156169 SGTC_628 1636-0253 16 µM 1.16776977032321 0.11519625992895 no 447 0.121449822452494 688 4456143 SGTC_2034 5197015 53.07 µM 1.16627197830848 0.11549801117337 no 448 0.121752249460513 652 780676 SGTC_1514 1189-1591 158 µM 1.16434424175223 0.115887206803176 no 449 0.122142267054718 685 767698 YMR146C TIF34 SGTC_389 tpck 16.7 µM 1.16325011799308 0.116108516036555 no 450 0.122364018834779 644 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2941 9056145 11.23 µM 1.16247031522565 0.116266430305934 no 451 0.122522237899682 552 2119517 SGTC_2906 7926292 26.41 µM 1.15711335287945 0.117355364182072 no 452 0.123613025951423 650 2966319 SGTC_2566 crystal violet carbinol 226 nM 1.14968838741812 0.118876584107174 no 453 0.125136119468105 573 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_333 3486-0131 40.1 µM 1.14864260821233 0.119091956218377 no 454 0.125351690042804 678 6744690 SGTC_2043 5101342 149 µM 1.14857120380943 0.119106671577833 no 455 0.125366418361571 657 678451 SGTC_2973 9094665 17.96 µM 1.14810972497701 0.119201806290694 no 456 0.125461635004245 731 25237061 YIL048W NEO1 SGTC_3260 9137109 49.47 µM 1.14660846105967 0.1195116656367 no 457 0.125771738995285 546 17478346 SGTC_2379 9035213 200 µM 1.14566036507433 0.119707644183135 no 458 0.125967854771462 718 646551 SGTC_2293 7624732 200 µM 1.14488820366436 0.11986742310485 no 459 0.126127735563818 603 894453 SGTC_2213 7173844 200 µM 1.1447850749269 0.119888774317886 no 460 0.12614909970963 702 892728 SGTC_3126 9127922 49.47 µM 1.14397035943649 0.120057542842297 no 461 0.126317964823986 647 45595682 SGTC_1930 st074634 34.3 µM 1.142813435387 0.1202974875539 no 462 0.126558029662925 671 684253 YOR116C RPO31 SGTC_1838 st055369 84.5 µM 1.13969299059402 0.120946347992534 no 463 0.127207114205364 622 676036 SGTC_3342 9147791 14.508 µM 1.13899201106986 0.121092446699536 no 464 0.127353243160021 676 1838168 SGTC_2160 5660466 132.927 µM 1.13387996673577 0.122161657514388 no 465 0.128422450740736 651 2859134 SGTC_1885 st057546 99.9 µM 1.1324612061313 0.122459570280145 no 466 0.128720292595629 708 702008 SGTC_1061 3448-9325 110 µM 1.12994569485555 0.122989032393488 no 467 0.129249553900388 648 723482 SGTC_2201 6605497 169.863 µM 1.12992356335964 0.122993697717879 no 468 0.129254217031252 660 670741 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.12766065715638 0.123471373886302 no 469 0.129731629536484 719 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_3164 9100705 49.47 µM 1.12643004332763 0.123731688578928 no 470 0.129991768052939 629 17174235 SGTC_2259 7964009 200 µM 1.12531008985621 0.123968928776718 no 471 0.130228827797804 635 313134 SGTC_2865 9030313 51.95 µM 1.12404263471635 0.124237798084682 no 472 0.130497469724893 632 42562754 SGTC_3095 9117207 49.47 µM 1.12193753540282 0.124685260350549 no 473 0.130944499889315 643 17015229 SGTC_549 1661-1316 519 µM 1.12163869925655 0.124748872480816 no 474 0.131008045161208 702 2857282 SGTC_373 0844-0104 25.9 µM 1.12129459938987 0.124822147818486 no 475 0.131081241812361 739 5375804 SGTC_918 glabranin 770.725 nM 1.12084079150535 0.124918831224553 no 476 0.131177818658718 697 124049 Also referred to as licorice root. SGTC_1233 0325-0408 14.2 µM 1.11882922334939 0.125348024099204 no 477 0.131606500991523 684 12874 SGTC_1777 st045864 34.765 µM 1.11456829422826 0.126260542701093 no 478 0.132517731700954 709 4691462 SGTC_3347 9188721 44.724 µM 1.11362097381376 0.126464047901933 no 479 0.132720912340204 659 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1301 naphtanilide LB 4.81 µM 1.11138483255417 0.126945326081462 no 480 0.133201369068569 739 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2639 lactacystin 53 µM 1.1073742384051 0.127811705216163 no 481 0.134066079613447 725 3870 A proteasome inhibitor. SGTC_301 4119-0100 24.5 µM 1.10598905331238 0.128111889076569 no 482 0.134365628731046 748 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_470 aa-861 153 µM 1.1056064348288 0.128194892683616 no 483 0.134448451706899 723 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3197 9113331 49.47 µM 1.10520651689579 0.128281689069853 no 484 0.134535056840079 701 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1787 fluconazole 80 µM 1.10460027161074 0.128413343616361 no 485 0.134666416673798 743 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2357 9067248 200 µM 1.10396161676918 0.128552137768601 no 486 0.134804894113629 656 9150235 SGTC_519 k048-0011 62.8 µM 1.10316006274847 0.12872648088789 no 487 0.134978830663777 684 6836379 SGTC_969 1313-0238 134 µM 1.10234769041994 0.128903344372717 no 488 0.135155271776956 740 5212874 SGTC_348 k064-0012 10.7 µM 1.10023231489873 0.129364678334297 no 489 0.135615457106481 660 5066323 SGTC_1344 1488-0097 29.1 µM 1.09728719651427 0.130008871131197 no 490 0.136257933024936 684 747966 SGTC_1187 1391-0724 117 µM 1.09636861962509 0.13021024716112 no 491 0.136458745468694 739 6997986 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.09343417955147 0.130854998571037 no 492 0.137101606733871 762 688801 SGTC_199 4063-0024 41.6 µM 1.09248895427103 0.131063151293443 no 493 0.137309121452799 737 306215 SGTC_80 0159-0065 512.242 µM 1.09203222850172 0.131163811053239 no 494 0.137409467833953 610 1548079 SGTC_601 0986-0029 62.9 µM 1.08711834242282 0.132250181820366 no 495 0.138492256265239 741 24747981 SGTC_266 formosanin C 406 nM 1.08465925660598 0.1327961632462 no 496 0.13903629976702 731 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2671 danthron 100 µM 1.08410171887943 0.132920166773128 no 497 0.13915985040794 713 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_121 0557-0495 61.343 µM 1.07843367308867 0.134185338099421 no 498 0.140420133256349 899 3104427 SGTC_2084 5306078 60.6385 µM 1.07612662756378 0.134702657533146 no 499 0.140935314224086 704 679340 SGTC_2368 9071271 200 µM 1.07441712698919 0.135086868422294 no 500 0.141317884829666 702 27209959 SGTC_1971 st069429 63.5 µM 1.07215034586917 0.135597486234357 no 501 0.141826254360089 713 1246522 YGL099W LSG1 SGTC_1066 ketoconazole 628 nM 1.07116713901766 0.135819375218536 no 502 0.142047142135608 774 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_3065 9113888 49.47 µM 1.07103100354461 0.135850117701386 no 503 0.142077744747827 681 16648368 SGTC_3002 9075603 71.4286 µM 1.07001872886968 0.136078861768989 no 504 0.142305439279977 739 20105405 SGTC_652 0437-0092 114 µM 1.06907160790995 0.136293121632606 no 505 0.14251870200426 708 3091274 SGTC_82 0054-0107 293.755 µM 1.06739560444422 0.13667283634602 no 506 0.142896616252557 734 3104697 SGTC_141 0443-0274 32.331 µM 1.06451411710873 0.137327354481655 no 507 0.143547931324813 846 1627241 SGTC_1000 4048-0884 8.67 µM 1.06391988662405 0.137462597312752 no 508 0.143682496656783 720 13040088 SGTC_3276 9139060 49.47 µM 1.06221897353341 0.13785021614598 no 509 0.144068144131365 688 4870619 SGTC_860 0443-0016 25.1 µM 1.05887765606344 0.138613834095483 no 510 0.144827750695983 765 5337942 SGTC_578 3460-0051 92 µM 1.05822212948184 0.138763984320832 no 511 0.144977092308806 851 2876744 SGTC_1398 3558-0053 112 µM 1.05592814016486 0.139290300995642 no 512 0.145500523306966 676 4532369 SGTC_1457 k015-0032 57.3 µM 1.05478696547302 0.139552629315152 no 513 0.145761383637781 748 4302660 SGTC_3021 9087658 49.47 µM 1.05250069128791 0.140079198501249 no 514 0.146284946765266 728 25237042 SGTC_2344 7990960 76.95 µM 1.05148980521314 0.140312453200735 no 515 0.14651684462087 713 140813 SGTC_2071 5230951 39.92 µM 1.05042509036272 0.140558413569774 no 516 0.14676135750159 793 1799272 SGTC_2101 5377231 179.231 µM 1.05026264423527 0.140595966057512 no 517 0.14679868748209 741 2844213 SGTC_340 k038-0059 454 µM 1.04773325301117 0.141181561122598 no 518 0.14738076118402 771 23733424 SGTC_3055 9094636 49.47 µM 1.04758970810412 0.141214843610825 no 519 0.147413840629444 726 25236176 SGTC_876 0720-0963 56.8 µM 1.04503951022296 0.141807022208818 no 520 0.148002354559815 801 765861 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.04437826547608 0.141960843277708 no 521 0.148155207636543 805 4174840 SGTC_2207 7258803 200 µM 1.04271458070713 0.142348354953029 no 522 0.148540251427352 710 3666799 SGTC_1217 1183-1422 255 µM 1.04163608380277 0.142599944460647 no 523 0.148790216289081 813 2849664 SGTC_126 0417-1624 672.48 µM 1.0410917397439 0.142727042020724 no 524 0.14891648642875 906 41912 YDL195W SEC31 SGTC_2296 7971656 126.45 µM 1.04015329000989 0.142946338124727 no 525 0.149134344359222 744 666570 SGTC_2797 7859098 81.82 µM 1.0398381692505 0.143020026303953 no 526 0.149207546292887 750 972681 SGTC_390 dec-rvkr-cmk 16.7 µM 1.03855326589447 0.1433207551515 no 527 0.149506275167386 790 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_95 0471-0001 561.058 µM 1.03757257063848 0.143550571890162 no 528 0.149734546716186 727 4015405 SGTC_349 k015-0014 24 µM 1.03437409436874 0.144301832680385 no 529 0.150480655143722 712 2196908 SGTC_3345 9148410 3.559 µM 1.03303072263622 0.144618153830978 no 530 0.150794760697561 766 4903596 SGTC_1477 0139-0234 16 µM 1.03272457162107 0.144690307926644 no 531 0.150866405588353 782 620880 SGTC_1670 st016595 4.04 µM 1.0321884916299 0.144816710395352 no 532 0.150991912597893 793 597879 SGTC_490 phenamil 164 µM 1.02569247004796 0.146354318947553 no 533 0.15251828240137 670 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_815 1582-0027 36.9 µM 1.02489875258138 0.146542940639325 no 534 0.152705481637816 781 3128206 SGTC_2203 7227154 166.4 µM 1.02438972841617 0.146663992692302 no 535 0.152825615789471 757 896304 SGTC_2130 NSC 7 2.4545 µM 1.02268947997174 0.147068818441869 no 536 0.153227343481068 817 21448 SGTC_1302 1159-0335 255 µM 1.02155663480641 0.147338962133043 no 537 0.153495395560973 759 649284 SGTC_1596 piperlongumine 63 µM 1.02066810900747 0.147551076816853 no 538 0.153705854361889 846 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3288 9119690 36.221 µM 1.01465457734221 0.148992042107555 no 539 0.155135256716738 709 17595618 YKL019W RAM2 SGTC_577 r071-0003 38.6 µM 1.01185352436326 0.149666430456484 no 540 0.155804046830171 918 4568517 YMR134W ERG29 SGTC_1324 1418-0026 34.4 µM 1.01110403305458 0.149847224660889 no 541 0.15598332014302 806 1372513 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.0107166158059 0.149940735521511 no 542 0.156076041042416 786 390807 SGTC_1950 st077106 7.18 µM 1.0100038921206 0.150112867187546 no 543 0.156246712661325 799 13831864 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.00909501757433 0.150332562763926 no 544 0.156464533631641 715 2374 Ca(2+)-ATPase inhibitor. SGTC_1571 st070080 73.4 µM 1.0055040206753 0.151202682795453 no 545 0.157327107202438 784 4315245 SGTC_1448 4255-0083 152 µM 1.00502948332835 0.151317916150142 no 546 0.157441326603386 830 5399660 SGTC_1116 jasmonic acid  1.58368 µM 1.00131073545259 0.1522229730462 no 547 0.158338302180452 814 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1616 st002734 56.1 µM 0.997109191059046 0.153249847046789 no 548 0.159355756111549 827 4026101 SGTC_1921 5740136 50 µM 0.996869015968354 0.153308685153249 no 549 0.159414046431 849 1774243 SGTC_712 r015-0009 80.6 µM 0.994882761400017 0.153795851550112 no 550 0.159896643987723 763 6813872 YLR060W FRS1 SGTC_139 0099-0334 718.624 µM 0.99409194378659 0.15399009938007 no 551 0.160089053558902 936 97690 SGTC_453 enantio-paf c16 10 µM 0.992788943605945 0.154310508098794 no 552 0.160406409575374 903 13871343 A lipid and platelet activating factor SGTC_300 r073-0011 5.04 µM 0.989751848139177 0.155059042277928 no 553 0.161147712880615 901 2735780 SGTC_274 sirtinol 40.1 µM 0.989471334561499 0.155128299474928 no 554 0.161216294053198 806 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_992 3909-8734 162 µM 0.98630583900448 0.155911257621242 no 555 0.161991527668644 795 4288319 SGTC_2985 9022375 71.43 µM 0.983950265204787 0.156495576158735 no 556 0.162569983647777 821 4939335 SGTC_1707 st032323 6.317 µM 0.983310774884783 0.156654455288388 no 557 0.162727254336124 811 3132057 YMR211W DML1 SGTC_3039 9090270 49.47 µM 0.981008255561675 0.15722738722359 no 558 0.163294335229495 778 17173750 SGTC_2068 5226020 147 µM 0.980732443417178 0.157296109373064 no 559 0.163362350220955 856 1810509 SGTC_2648 atorvastatin 78.68 µM 0.978680544073929 0.157807986371349 no 560 0.163868924115175 804 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_831 k061-1017 217 µM 0.978592848259316 0.157829887755187 no 561 0.163890597191103 962 1240153 SGTC_3060 1327-0027 12.5 µM 0.975648988038934 0.158566253368255 no 562 0.164619219720329 792 16000455 YPR107C YTH1 SGTC_1516 st013856 110 µM 0.975630166843446 0.15857096846467 no 563 0.164623884818269 788 5281404 A mutagen and neurotoxin. SGTC_1529 apigenin 74 µM 0.975316320138759 0.158649607066391 no 564 0.164701688760969 832 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3009 9080819 71.4286 µM 0.973933027111378 0.158996514805243 no 565 0.165044896879552 829 17027216 SGTC_639 0833-0042 114 µM 0.970060523070945 0.159970318194367 no 566 0.166008162483409 858 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2029 5175081 200 µM 0.969993360746558 0.15998724157902 no 567 0.166024900754407 856 1380876 SGTC_1013 4112-3890 241 µM 0.969306890969969 0.16016028355406 no 568 0.16619604606774 814 705171 SGTC_2240 6690706 185.951 µM 0.968910133371462 0.160260352061276 no 569 0.166295014538607 708 805876 SGTC_646 4092-0839 27.3 µM 0.968895986572277 0.160263920860928 no 570 0.166298544063566 876 877796 SGTC_715 0868-0130 184 µM 0.967342614316182 0.160656104599262 no 571 0.16668639359788 816 2876258 SGTC_1030 k029-0042 36.7 µM 0.966188394553414 0.16094791887308 no 572 0.166974959519452 861 6080581 SGTC_2708 st078559 56 µM 0.964265875262287 0.16143474516759 no 573 0.167456322431739 758 17250902 SGTC_593 1203-0218 61.7 µM 0.960455759711048 0.16240238865641 no 574 0.16841294320494 888 3666956 SGTC_35 0133-0054 64.071 µM 0.959783554825619 0.162573497441082 no 575 0.168582080328894 792 99677 SGTC_2864 9034755 47.6 µM 0.959388856822739 0.16267402188538 no 576 0.168681443302555 901 4930451 SGTC_1027 k015-0025 8.67 µM 0.958871121068058 0.16280594373453 no 577 0.168811837387036 834 3598955 SGTC_605 1315-0399 119 µM 0.958761176241384 0.162833967220006 no 578 0.168839535822429 889 24020461 SGTC_132 0417-1715 25.805 µM 0.957397873848221 0.163181715588006 no 579 0.169183235600411 877 6769098 SGTC_2558 carylophyllene oxide 100 µM 0.957130304353809 0.16325002327699 no 580 0.169250744775994 907 6708694 An oxygenated terpenoid and antifungal agent. SGTC_732 3970-1727 52.7 µM 0.956766530479161 0.163342920731698 no 581 0.169342554551655 861 1275699 SGTC_1645 Cervolide 78 µM 0.954527539954889 0.163915450941355 no 582 0.169908337887005 811 23173 A fragrance. SGTC_2274 7947094 46.08 µM 0.953611828288006 0.164149981468633 no 583 0.170140083094259 909 2971028 SGTC_2834 9001755 58.44 µM 0.953385027869535 0.164208102821137 no 584 0.170197512258228 767 2989575 SGTC_185 k048-0037 25.491 µM 0.951056006361242 0.164805725134774 no 585 0.170787972907616 881 6827589 SGTC_2318 6029776 164 µM 0.950965452997819 0.164828989366495 no 586 0.170810956718438 841 818325 SGTC_1999 st074831 12.5 µM 0.949275654408875 0.165263508811965 no 587 0.171240216181288 857 17112523 SGTC_2981 9013952 38.96 µM 0.948382751916353 0.165493411277711 no 588 0.171467318445485 765 2996344 SGTC_1643 st009866 20.2 µM 0.947692236600358 0.165671345348519 no 589 0.171643077152788 868 3156273 YOR207C RET1 SGTC_1927 st060202 13.8 µM 0.947502173900512 0.16572034298148 no 590 0.171691474512065 845 688887 SGTC_2153 5569715 200 µM 0.946960180509244 0.165860118812353 no 591 0.171829534988216 855 2054701 SGTC_1773 st048542 73.5835 µM 0.946367451370243 0.166013066204655 no 592 0.171980600380689 833 3237138 SGTC_2854 9024559 71.43 µM 0.945684759194188 0.166189340491774 no 593 0.172154699159574 834 3163529 SGTC_3257 9139206 32.98 µM 0.942218898026878 0.16708610604256 no 594 0.17304029023045 834 4910041 SGTC_2157 5649910 96.377 µM 0.942121813678449 0.167111270730386 no 595 0.173065138774197 848 2858091 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.940768966145891 0.167462188984123 no 596 0.173411633875344 889 688798 SGTC_591 4299-0174 154 µM 0.939385094131368 0.167821645622558 no 597 0.173766531619399 873 5509088 SGTC_3087 9117406 49.47 µM 0.93902545435532 0.167915142248866 no 598 0.173858837799965 825 42546093 SGTC_3142 9086498 49.47 µM 0.937731473096719 0.16825181971204 no 599 0.174191212643735 802 25236367 SGTC_508 roscovitine 141 µM 0.936655407721003 0.1685321287083 no 600 0.174467920474106 890 160355 A CDKinase inhibitor. SGTC_3201 9113999 49.47 µM 0.932948987752326 0.169499926872197 no 601 0.175423153714893 823 16649224 SGTC_343 4130-2827 29.8 µM 0.93262369024846 0.169585036498179 no 602 0.175507148645678 867 1118244 SGTC_466 geldanamycin 89.2 µM 0.932577615648041 0.169597093501085 no 603 0.175519047609339 775 5288382 HSP90 inhibitor. SGTC_403 arphamenine a 50 µM 0.931850325000785 0.169787486947144 no 604 0.175706941277552 867 5487158 An arginine aminopeptidase inhibitor. SGTC_311 1315-0136 58 µM 0.931232891375812 0.169949229055245 no 605 0.175866553642018 874 6759207 SGTC_753 1322-0200 289 µM 0.930073601024271 0.17025318198729 no 606 0.176166489023966 893 5403907 SGTC_2861 9024595 19.48 µM 0.930058927228228 0.170257031522836 no 607 0.176170287550206 817 16482810 SGTC_1824 st053723 68.6 µM 0.92905942478935 0.170519373058799 no 608 0.176429145362669 902 675225 SGTC_3255 9139072 49.47 µM 0.928207969420117 0.170743060422594 no 609 0.176649850651171 892 17646060 SGTC_1254 0550-0035 264 µM 0.92526043746319 0.171518861421038 no 610 0.177415226292846 924 15121435 SGTC_3116 9124943 49.47 µM 0.922706272412586 0.172192945570697 no 611 0.178080148110162 847 41905195 YPL160W CDC60 SGTC_531 3788-1495 174 µM 0.920927751295014 0.172663322201323 no 612 0.178544074367038 831 2896655 SGTC_2693 st077581 40.7 µM 0.919881687230679 0.17294036355449 no 613 0.17881729480268 957 25238761 SGTC_2381 9035592 200 µM 0.918404960387861 0.173331944215553 no 614 0.179203447373565 818 4749657 SGTC_573 3702-0553 84.7 µM 0.915323568717471 0.174150846816148 no 615 0.180010894826242 858 1222756 SGTC_1456 k015-0012 13 µM 0.915157129581884 0.174195149133186 no 616 0.180054573444987 963 2989616 SGTC_2580 diallyl disulphide 81.36 µM 0.91476739798513 0.17429891485007 no 617 0.18015687672984 833 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1038 k292-0204 154 µM 0.911512644464727 0.175167023354992 no 618 0.181012663181503 827 4454212 SGTC_2593 nobiletin 86.24 µM 0.911364771449704 0.17520652909268 no 619 0.181051604470687 827 72344 An anti-infammatory. SGTC_1845 st056753 3.01 µM 0.911047644229354 0.175291271816378 no 620 0.181135135327718 897 5375839 SGTC_499 genistein 192 µM 0.908528670318187 0.175965314790474 no 621 0.18179948664056 903 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_365 0121-0052 13.6 µM 0.906812058739441 0.176425595607698 no 622 0.182253095967515 936 3101739 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.903829515057637 0.177227124481948 no 623 0.183042904329476 981 1377 SGTC_3152 9099253 49.47 µM 0.903170599570626 0.177404511134946 no 624 0.183217679528069 964 25236131 SGTC_1269 0831-0796 3.05 µM 0.898761644216084 0.178594328743518 no 625 0.184389817160711 920 927758 SGTC_926 2268-1401 59.4 µM 0.897941672789346 0.178816162345113 no 626 0.184608323079934 917 2931578 SGTC_2255 7941087 197.44 µM 0.897764885422301 0.178864012802192 no 627 0.184655454454476 983 935561 SGTC_2226 7298446 200 µM 0.897303202157025 0.178989013099776 no 628 0.184778574131734 890 3283010 SGTC_2175 5807670 165.306 µM 0.897267351089341 0.178998722041141 no 629 0.184788136872544 906 241186 SGTC_2902 5787006 60.46 µM 0.896894153098153 0.179099808651559 no 630 0.184887700171675 875 591003 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.894457646016348 0.179760657676644 no 631 0.185538540621997 972 5106787 A p450 inhibitor. SGTC_2750 bromebric acid 70.15 µM 0.894056915746316 0.179869493471135 no 632 0.185645719798521 960 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2066 5222451 176 µM 0.890409889914947 0.180861904046446 no 633 0.186622916930959 997 2281147 SGTC_1667 st014849 34.6 µM 0.888773765966596 0.181308231008068 no 634 0.187062338791982 932 5348460 SGTC_1669 st015249 58.4 µM 0.888765531129302 0.181310479176195 no 635 0.187064552080283 1026 722793 SGTC_1004 4084-0029 199 µM 0.88831425471016 0.181433707481115 no 636 0.187185867017224 975 716894 YLR208W SEC13 SGTC_518 1021-0119 62.6 µM 0.887592702919724 0.181630847743837 no 637 0.187379940124401 846 1097762 SGTC_2832 7992762 51.95 µM 0.887062012415933 0.181775926960575 no 638 0.18752275733148 787 2985177 SGTC_154 3389-1638 511.116 µM 0.886400225847231 0.181956946520981 no 639 0.187700948779728 808 5238686 SGTC_1419 3993-2473 62.6 µM 0.885521046382277 0.182197604202817 no 640 0.187937836762246 946 704026 SGTC_2761 levamisole 97.89 µM 0.884088879580207 0.182590056800143 no 641 0.188324117868752 911 26879 An alkaline phosphatase inhibitor. SGTC_173 1273-0061 2.693 µM 0.88296491262321 0.182898423710718 no 642 0.188627614709033 893 2847414 YPL266W DIM1 SGTC_1736 st036774 51 µM 0.882316628338806 0.183076432004472 no 643 0.188802803361734 978 1272247 SGTC_555 4296-0685 37 µM 0.880421470449426 0.183597430996358 no 644 0.189315514788391 962 2908540 YHR072W ERG7 SGTC_2390 9097792 176.6 µM 0.879615479619072 0.183819286172573 no 645 0.189533825115239 883 4497149 SGTC_976 1348-1067 47.6 µM 0.879294507472014 0.183907682695978 no 646 0.189620806599643 1024 5310671 YGL099W LSG1 SGTC_989 1501-0895 10.3 µM 0.879189542839924 0.18393659595853 no 647 0.189649256699016 962 2830112 SGTC_2630 antimycin a 100 µM 0.87793192049591 0.184283237177904 no 648 0.189990332642568 995 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_200 k038-0079 37.545 µM 0.875505735038768 0.184953119680183 no 649 0.19064939555127 925 3436683 SGTC_2514 salinomycin 42.74 µM 0.873757007322087 0.185436889651263 no 650 0.191125299098864 1027 23682228 A polyether potassium ionophore. SGTC_2089 5281248 129.67 µM 0.87215672728454 0.185880280492524 no 651 0.191561441375073 911 2737878 SGTC_468 gf-109203x 121 µM 0.87127695747355 0.186124318842994 no 652 0.191801474426285 847 2396 A protein kinase C inhibitor. SGTC_3119 9125183 49.47 µM 0.868451038553221 0.186909539834256 no 653 0.192573732333184 811 22695334 SGTC_1931 st074438 57.1 µM 0.867563490795582 0.187156579747782 no 654 0.192816670143088 955 2787313 SGTC_401 neomycin 50 µM 0.865084447778839 0.187847665265265 no 655 0.19349622004997 914 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_673 1082-0474 110 µM 0.864959190654665 0.18788262510241 no 656 0.193530593989681 1044 3098046 SGTC_2855 9016525 58.44 µM 0.861710341463171 0.188790796836957 no 657 0.194423466685955 987 43811474 SGTC_2704 st078022 71.1 µM 0.860981402619661 0.188994932796387 no 658 0.194624142941979 970 54697681 SGTC_189 3970-0742 2.116 µM 0.860504904508469 0.189128447356661 no 659 0.194755390570817 972 2891807 SGTC_303 1348-1668 34.2 µM 0.857227616826126 0.190048314726773 no 660 0.195659551312066 946 5380509 SGTC_742 0kpi-0133 140 µM 0.856348265386519 0.190295597731212 no 661 0.195902585787022 984 2728852 SGTC_681 1642-0006 26.6 µM 0.855872716592969 0.190429409430874 no 662 0.196034093876919 974 4446530 SGTC_734 2023-0417 80 µM 0.855012449116176 0.19067162147926 no 663 0.196272127946437 948 3935732 SGTC_2886 9058944 51.95 µM 0.853729576495033 0.191033170896948 no 664 0.196627421234576 833 4949929 SGTC_790 1575-0012 79.1 µM 0.853565562249836 0.191079424997119 no 665 0.196672873272806 1010 378741 YLR208W SEC13 SGTC_396 dithiazanine 1.25 µM 0.853408791780098 0.191123642679498 no 666 0.19671632384607 935 10578 An antihelmenthic. SGTC_3135 9127742 49.47 µM 0.852216802179064 0.191460052867363 no 667 0.197046886343459 900 3643468 SGTC_2785 7756463 72.73 µM 0.849730084604549 0.192163035696711 no 668 0.197737584130179 982 2201551 SGTC_2291 7917025 104.35 µM 0.849286916110892 0.192288482832021 no 669 0.197860829736406 931 2964612 SGTC_784 4579-0127 173 µM 0.849265517726494 0.192294541312516 no 670 0.197866781822989 1032 1948547 SGTC_122 0236-0016 402.397 µM 0.847147603610956 0.192894759460649 no 671 0.198456427143893 1067 6808838 SGTC_2032 5185112 25.99 µM 0.845609166411817 0.193331470187731 no 672 0.198885405140609 941 5718189 SGTC_342 k048-0088 23.3 µM 0.844927415564486 0.193525189156567 no 673 0.199075683202128 979 6820570 SGTC_867 0518-0118 155 µM 0.843404087289709 0.193958469325 no 674 0.199501243396574 1020 6848158 SGTC_363 0455-0021 3.06 µM 0.841339501377899 0.194546641999143 no 675 0.200078883637065 972 4597466 SGTC_1215 3852-0577 11.2 µM 0.840408337878192 0.194812272728537 no 676 0.200339737897184 1051 2884876 SGTC_3297 9117502 71.43 µM 0.83984991159969 0.194971679388209 no 677 0.200496272266881 994 7453720 SGTC_638 3970-0837 4.09 µM 0.838963120191737 0.195224983066125 no 678 0.200745002671249 964 4118451 YLR208W SEC13 SGTC_3132 9126706 49.47 µM 0.838227334797734 0.195435305011192 no 679 0.200951518894916 931 850858 SGTC_3321 9137793 26.8275 µM 0.836633555337081 0.195891353551906 no 680 0.201399289049908 1009 4904192 SGTC_117 lucigenin 22.078 µM 0.835887368528682 0.196105091295495 no 681 0.201609134574318 1032 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1051 3253-3903 78 µM 0.835376413442471 0.196251530819489 no 682 0.201752902852954 1032 5509239 SGTC_821 1114-0266 29.2 µM 0.835101497179036 0.196330349136397 no 683 0.201830281894612 967 3123235 SGTC_667 1498-1044 59 µM 0.834879397367017 0.196394039021568 no 684 0.201892807979456 1017 6739982 SGTC_492 tmb-8 126 µM 0.832842368065364 0.196978766469974 no 685 0.202466818215556 860 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1547 harmine 94.2 µM 0.829679768638781 0.197888673224459 no 686 0.203359931497147 1072 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2753 fluvastatin 17.09 µM 0.827955033446198 0.198385962356828 no 687 0.203847983074708 975 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_769 0302-0231 76 µM 0.827639419394721 0.198477044220423 no 688 0.203937368483165 1050 571869 YER009W NTF2 SGTC_2802 7925815 54.55 µM 0.826958808946987 0.198673544853575 no 689 0.204130204401119 973 1262923 SGTC_3166 9102297 49.47 µM 0.826258623812321 0.198875819317932 no 690 0.20432869966762 1002 25237072 SGTC_26 0302-0163 425.158 µM 0.826156135970187 0.198905437146175 no 691 0.204357763552313 1025 3100915 SGTC_697 0508-1955 564 µM 0.826080963327358 0.198927162880505 no 692 0.204379082855395 1041 6243113 SGTC_3231 9132313 49.47 µM 0.822121943079556 0.200073384107555 no 693 0.205503749006619 997 4905967 SGTC_455 paf C-16 10 µM 0.821736097816229 0.200185306512321 no 694 0.205613554902517 963 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2779 methotrexate 400 µM 0.821632749347874 0.200215291262545 no 695 0.20564297227165 1104 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2330 7979373 200 µM 0.8199172919375 0.200713395337408 no 696 0.206131629190186 987 1863007 SGTC_2928 9011484 9.79 µM 0.818648618117506 0.201082248361615 no 697 0.206493459940592 955 2994751 SGTC_2339 9000433 200 µM 0.817247542651387 0.201490067771427 no 698 0.20689348905057 941 2988954 SGTC_2814 7977482 42.97 µM 0.815240617250411 0.202075098206995 no 699 0.207467296215596 1060 6456762 SGTC_2908 7930301 100 µM 0.814123770093342 0.202401105436946 no 700 0.207787024929524 1034 2223178 SGTC_1424 4048-1941 275 µM 0.813367319487397 0.20262209160251 no 701 0.208003745274837 1097 X1424 SGTC_295 k015-0027 31 µM 0.812037768405926 0.203010850127648 no 702 0.208384980037688 997 3887424 SGTC_1186 1319-0216 26 µM 0.811914159833491 0.203047015684636 no 703 0.208420444420165 1075 4565136 SGTC_2051 5263410 176 µM 0.810677167506018 0.203409148346139 no 704 0.208775544366174 1092 227584 SGTC_3323 9138564 53.9225 µM 0.809171262969707 0.203850525438355 no 705 0.209208321041907 1089 43912313 YNL103W MET4 SGTC_2321 7390090 138.78 µM 0.808320231950434 0.204100212886752 no 706 0.209453129277605 962 649046 SGTC_1886 st057356 49.9 µM 0.80822778576999 0.204127347012493 no 707 0.209479732561746 966 24207747 SGTC_16 erodoxin 22.806 µM 0.807504837633153 0.204339615547364 no 708 0.209687844262153 1064 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1638 st008370 60.6 µM 0.806142270516472 0.204740042979564 no 709 0.210080410429154 1043 24207134 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.804931751901275 0.205096178033753 no 710 0.210429532160397 1015 2724278 An inhibitor of dopamine biosynthesis. SGTC_3269 9137823 49.47 µM 0.804584412079666 0.20519843348222 no 711 0.210529770153903 954 17682936 SGTC_561 1550-0330 72.9 µM 0.801904510078808 0.20598840383513 no 712 0.211304098524075 1009 6812934 SGTC_248 streptozotocin 5.23457 mM 0.801730730104981 0.20603969217122 no 713 0.211354367881704 1080 5300 DNA alkylating agent. SGTC_2115 tiliquinol 12.7705 µM 0.800935787272157 0.206274403171411 no 714 0.211584410402602 1008 71208 A bioactive hydroxyquinoline. SGTC_2319 6033012 152.6 µM 0.800626730376526 0.206365696590333 no 715 0.211673885607023 959 847246 SGTC_794 k038-0031 316 µM 0.800257050691001 0.206474929034305 no 716 0.211780940826432 1050 6624242 SGTC_868 0527-0199 213 µM 0.799469849626566 0.20670764421872 no 717 0.212009011233898 1004 2849450 SGTC_1972 st070201 17.4 µM 0.79681307417178 0.207494195399219 no 718 0.21277980041062 1030 2829099 SGTC_147 4466-0538 29.23 µM 0.796701019302501 0.207527408615008 no 719 0.212812345914402 1165 6742687 YHR072W ERG7 SGTC_2598 perillyl alcohol 100 µM 0.795732409188869 0.207814636909851 no 720 0.213093792616943 1051 10819 An apoptosis inducer. SGTC_1342 1486-1464 234 µM 0.79173780055352 0.209001662619106 no 721 0.214256788255371 1081 3253938 SGTC_3155 9099265 49.47 µM 0.78860202953436 0.209936270389788 no 722 0.215172322187556 978 25236499 SGTC_3091 9116372 49.47 µM 0.788283982384519 0.210031200450303 no 723 0.215265307348447 1014 17169793 SGTC_3307 9126885 69.2785 µM 0.787373542319486 0.210303086132406 no 724 0.215531615058489 1044 24824909 SGTC_2257 7960413 200 µM 0.786601654563789 0.210533757590246 no 725 0.215757545204393 1078 2974689 YIL048W NEO1 SGTC_2536 dehydroabietamide 32.04 µM 0.785354478734553 0.210906778071165 no 726 0.216122881255849 1077 3983547 SGTC_1161 k007-0610 110 µM 0.784057825880446 0.211295007333582 no 727 0.216503090241076 1120 5843850 SGTC_913 3487-1245 167 µM 0.783778192892534 0.211378786753001 no 728 0.216585135885256 1039 4016153 SGTC_2261 9010538 184.68 µM 0.782373661777996 0.211799885377995 no 729 0.216997503937303 987 6457250 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.782220165110015 0.211845935621019 no 730 0.217042597797326 1141 6708784 An antioxidant flavonoid SGTC_1048 3161-0300 24.5 µM 0.781260294041482 0.212134037534652 no 731 0.217324709056845 1126 2165101 SGTC_1644 st010134 20.9 µM 0.781026710176706 0.212204181547282 no 732 0.217393392629739 1050 3818134 SGTC_1710 st031758 61.5 µM 0.780086851123422 0.212486553300499 no 733 0.217669877729071 1046 5394341 SGTC_3340 9146634 11.102 µM 0.779835578135334 0.212562083060524 no 734 0.217743830870424 1072 4907387 SGTC_1270 0831-1170 17.3 µM 0.778298975990924 0.213024308964663 no 735 0.2181963895236 1092 6764716 SGTC_1884 5633444 25 µM 0.775756448852683 0.213790414141837 no 736 0.218946401465428 1066 5724239 SGTC_1836 st055642 81 µM 0.774607018907061 0.214137282249187 no 737 0.219285954274196 1097 8571 SGTC_1449 4112-4002 201 µM 0.774078293821119 0.21429694765111 no 738 0.219442246390691 1045 2059539 SGTC_1575 cyproterone acetate 48 µM 0.771972495149708 0.214933547461323 no 739 0.220065359060394 1045 9880 An androgen receptor antagonist and liver toxin. SGTC_1294 1000-1494 117 µM 0.770055526156221 0.215514016420378 no 740 0.220633477928015 1077 712797 YDL207W GLE1 SGTC_2959 9079155 11 µM 0.769477264131793 0.215689295746372 no 741 0.220805018258988 1071 16189457 SGTC_575 k072-0246 11.9 µM 0.769242089975093 0.215760603963999 no 742 0.220874804065328 1094 6796779 SGTC_2597 laccaic acid a 100 µM 0.767986102769532 0.216141668817682 no 743 0.221247720659174 1045 5491415 A textile dye. SGTC_260 nsc-65238 3.989 µM 0.764425412900332 0.217224093738529 no 744 0.222306884668551 1063 3246252 SGTC_3059 1327-0034 3 µM 0.7617973360198 0.218025015247341 no 745 0.223090485302623 1065 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_20 0481-0013 4.944 µM 0.761018192453068 0.218262790493469 no 746 0.223323100573185 1098 182045 SGTC_2435 5706476 10.6 µM 0.760525826700695 0.218413125289299 no 747 0.223470168751409 1131 5725375 SGTC_800 3448-7362 155 µM 0.760393217649962 0.218453625207712 no 748 0.223509788094281 1216 15991913 SGTC_2206 7254556 146.969 µM 0.759497431647538 0.218727319039903 no 749 0.223777524932814 1096 4398905 SGTC_1018 4259-0013 28.1 µM 0.758931937348699 0.218900198816189 no 750 0.223946636423641 1077 6801262 SGTC_2958 9077254 16.72 µM 0.75799809747051 0.21918585917613 no 751 0.224226060844304 1111 16457351 SGTC_2141 5621638 7.665 µM 0.757226493838052 0.219422053294823 no 752 0.224457090076699 1092 2856238 SGTC_1583 clindamycin 39.6 µM 0.757167090465009 0.219440243208748 no 753 0.224474881899983 1031 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2466 5983409 37.09 µM 0.757015505753526 0.219486663907105 no 754 0.224520286456777 1043 2879657 SGTC_2315 7733312 200 µM 0.756995522528685 0.219492783911122 no 755 0.224526272472023 1077 726316 SGTC_533 1222-0222 6.71 µM 0.756517555167977 0.219639194007761 no 756 0.224669475540227 1150 3982874 SGTC_118 0083-0097 135.343 µM 0.755863681141003 0.219839578327085 no 757 0.224865465620534 1199 5207356 SGTC_1220 1838-0075 193 µM 0.754333286770522 0.22030898848203 no 758 0.225324559768431 1067 5529645 SGTC_510 ag-490 170 µM 0.750760191940377 0.221407179993322 no 759 0.226398495396955 1212 5328779 SGTC_2239 6685329 187.64 µM 0.749015289780571 0.221944611530741 no 760 0.226923994962469 1070 805680 SGTC_1383 3049-0032 20.7 µM 0.747661509737188 0.222362089755502 no 761 0.227332176591157 1141 712864 SGTC_2843 9000894 45.46 µM 0.745738715725045 0.222955809550086 no 762 0.227912633455924 1012 2242070 SGTC_3200 9114385 49.47 µM 0.742312255855928 0.22401606595783 no 763 0.228949083968188 1118 17018030 YLR208W SEC13 SGTC_2212 7123476 200 µM 0.74185994066519 0.224156240465328 no 764 0.229086099574744 1074 1085715 SGTC_327 1273-0057 3.96 µM 0.741794647172031 0.224176479325431 no 765 0.229105882119793 1076 3108138 SGTC_1127 asiatic acid 681.4 nM 0.739941635431823 0.224751285176789 no 766 0.229667704731707 1085 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1439 4092-1168 46 µM 0.739517258179667 0.22488304489587 no 767 0.229796482016969 1113 2886240 SGTC_2416 tofa 880 nM 0.739087890454534 0.225016398598937 no 768 0.229926814798174 1063 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_996 3970-0799 1.8 µM 0.737914988355531 0.225380908696158 no 769 0.230283055145447 1260 6615648 YGL040C HEM2 SGTC_550 4123-0385 25.7 µM 0.737670437648808 0.22545695134218 no 770 0.230357370315128 1134 5731123 SGTC_1591 genipin 88.4 µM 0.737010546410499 0.225662215907574 no 771 0.230557967930689 1080 442424 A DNA cross-linking agent. SGTC_3203 9113543 49.47 µM 0.736898377497737 0.2256971174761 no 772 0.230592075400348 1111 17018012 SGTC_797 k781-0471 270 µM 0.736837095784972 0.22571618668638 no 773 0.230610710668284 1137 23738129 SGTC_1070 indatraline 8.81 µM 0.736507348337444 0.225818810812464 no 774 0.230710998616892 1123 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2320 7373003 200 µM 0.733392498394414 0.226789516601978 no 775 0.23165953660913 1147 5415828 SGTC_977 1348-1378 135 µM 0.732621585740802 0.227030125250601 no 776 0.231894630946894 1168 X977 SGTC_2840 9008771 71.43 µM 0.731149034384598 0.227490121348117 no 777 0.232344063216476 1115 2992978 SGTC_2800 7887935 81.82 µM 0.730177637545701 0.227793853750815 no 778 0.232640804918112 1103 2961002 SGTC_651 3253-0966 34.4 µM 0.729626448706664 0.227966298667081 no 779 0.232809275380262 1167 781462 SGTC_1920 st075728 45.7 µM 0.729464899063549 0.228016854993838 no 780 0.232858665752156 1120 3400306 SGTC_1841 st054148 70 µM 0.728936900213259 0.228182134141554 no 781 0.23302013078294 1099 675442 SGTC_3253 9135987 49.47 µM 0.728779198127205 0.22823151258654 no 782 0.233068369027414 1116 4182430 SGTC_3287 9117173 37.0625 µM 0.72788569735149 0.22851139196983 no 783 0.233341779595197 1122 2789709 SGTC_3080 9117754 49.47 µM 0.727454751584514 0.2286464499271 no 784 0.233473712267859 1176 9550191 SGTC_2129 girgensonine 121.053 µM 0.726631667555662 0.228904528136669 no 785 0.233725811763947 1166 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3026 9090633 49.47 µM 0.725043237439041 0.229403042671072 no 786 0.234212752718618 1159 25236842 SGTC_1962 st076595 64.5 µM 0.724259970978817 0.22964908765608 no 787 0.234453073453334 1175 279619 SGTC_247 mechlorethamine 29.705 µM 0.724094887567461 0.229700963633472 no 788 0.234503741519894 1096 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2022 5136654 200 µM 0.723996415147555 0.22973191083065 no 789 0.234533967956386 1131 1713771 SGTC_1249 0481-0015 10.2 µM 0.723801291151168 0.229793239880473 no 790 0.234593868281135 1130 4227577 SGTC_377 3970-0964 33.1 µM 0.723292108562241 0.229953323252712 no 791 0.234750220022479 1173 16481235 SGTC_1757 st041620 31.8375 µM 0.719618661987431 0.231110076371499 no 792 0.235879909281952 1182 5289815 SGTC_985 1493-0307 8.71 µM 0.716320440299494 0.232151433527305 no 793 0.236896754132853 1145 3278274 SGTC_1783 st039459 87.517 µM 0.715763969209862 0.232327386891755 no 794 0.23706855197686 1209 729761 SGTC_2737 bleomycin 30.5 nM 0.715552225774739 0.232394358583985 no 795 0.237133940943585 1196 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2828 7998861 71.43 µM 0.712538338060298 0.233348775367475 no 796 0.238065739893837 1088 2988188 SGTC_520 3584-0023 682 µM 0.712370140888149 0.23340210286398 no 797 0.238117800205153 1113 1340790 SGTC_228 caffeine 993.056 µM 0.711012069217112 0.233832931794811 no 798 0.238538378391185 1165 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_51 1013-0126 23.419 µM 0.710507747319985 0.233993032891567 no 799 0.238694664191897 1219 1627850 SGTC_1789 tunicamycin 25 nM 0.709192306677575 0.234410915855715 no 800 0.239102573505198 1178 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2202 7226349 200 µM 0.708012862647428 0.234785946909331 no 801 0.239468634902667 1145 844334 SGTC_429 1112-0049 25.5 µM 0.707110561705653 0.235073077803543 no 802 0.239748886500764 1146 2836170 SGTC_1800 st050079 29.0735 µM 0.706814532412786 0.23516732271208 no 803 0.239840871163643 1179 3645560 SGTC_1036 k216-0215 33.5 µM 0.706021170239186 0.235420003103168 no 804 0.240087486108846 1182 622330 SGTC_1282 0886-0010 32.4 µM 0.704715785382195 0.235836085095294 no 805 0.240493562895833 1240 2836211 YNL267W PIK1 SGTC_166 k072-0058 166.424 µM 0.704320575356954 0.23596213533914 no 806 0.240616577842221 1207 5846229 SGTC_1407 3909-7909 12.3 µM 0.703858709754413 0.236109492081788 no 807 0.240760383716545 1199 4411780 SGTC_3319 9138450 16.7555 µM 0.701704511116717 0.236797451456299 no 808 0.241431729576986 1144 2029690 SGTC_677 0929-0063 136 µM 0.70169441488312 0.236800678356815 no 809 0.241434878412926 1142 1539583 SGTC_706 4262-0057 46.9 µM 0.700797829160414 0.237087336366653 no 810 0.241714596508847 1175 883298 SGTC_2946 9065502 71.43 µM 0.700172067149041 0.23728751905861 no 811 0.241909926814844 1016 16489101 SGTC_1687 st020778 55.3625 µM 0.698647265204636 0.237775695123504 no 812 0.242386248904729 1201 4259299 SGTC_1303 1160-0052 261 µM 0.69751127277175 0.238139748872356 no 813 0.242741443588591 1208 3562476 SGTC_594 1487-1584 10.8 µM 0.697371887775652 0.23818443888664 no 814 0.242785044974989 1176 5013332 SGTC_2982 9019404 25.97 µM 0.697359056987974 0.238188552961268 no 815 0.242789058820394 1083 22333232 SGTC_3058 9093861 49.47 µM 0.697019918143066 0.238297308841477 no 816 0.242895164382669 1207 17217477 SGTC_1493 4348-0038 111 µM 0.696849346772565 0.238352018367366 no 817 0.242948540122351 1232 800424 SGTC_2264 7948757 110.76 µM 0.695435899734693 0.238805635792091 no 818 0.243391084547659 1194 2971411 SGTC_1522 st012842 45.6 µM 0.693577610292722 0.23940273430307 no 819 0.24397356944899 1104 3491067 YOR116C RPO31 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.692884732450158 0.239625575690758 no 820 0.244190945854443 1196 6312947 SGTC_1563 conessine 56.1 µM 0.691782511209908 0.239980302114762 no 821 0.244536960551265 1274 441082 An anti-amoebic, histamine inhibitor. SGTC_1181 1222-0449 220 µM 0.69165008722614 0.240022939212341 no 822 0.244578549501827 1248 658318 SGTC_1212 0520-0165 585 µM 0.691354152408235 0.240118237496497 no 823 0.244671504277735 1309 5403258 SGTC_767 0929-0023 86 µM 0.689648399080828 0.240667933835325 no 824 0.245207661543256 1283 1204563 SGTC_2436 5633522 8.09 µM 0.689099610398176 0.240844932089074 no 825 0.245380292592743 1206 5724242 SGTC_848 0368-0089 85.6 µM 0.688594411196015 0.241007934217096 no 826 0.245539269534338 1192 762535 SGTC_1418 3966-3099 2.4 µM 0.688527633516787 0.241029484471308 no 827 0.245560287387084 1210 740335 SGTC_558 k064-0027 21.3 µM 0.688171963227867 0.241144282768451 no 828 0.245672248643719 1214 5088526 SGTC_2338 7999974 200 µM 0.688022476947706 0.241192540735855 no 829 0.245719313529177 1258 315925 SGTC_1388 3346-4487 254 µM 0.686691374043267 0.241622485946397 no 830 0.2461386169386 1253 3345614 SGTC_1531 st059297 52.4 µM 0.685680011201951 0.241949433339902 no 831 0.246457457155547 1223 7566702 SGTC_2555 cholic acid 100 µM 0.685321231215173 0.242065475251071 no 832 0.24657061857199 1205 6708657 Influences liver metabolism. SGTC_2099 5377090 177.372 µM 0.684554277246298 0.242313635989844 no 833 0.246812613889119 1198 2243829 SGTC_2860 9025725 38.96 µM 0.684540184673915 0.24231819716607 no 834 0.246817061677094 1183 40546248 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.682720187302384 0.242907645013468 no 835 0.247391835500916 1212 688667 SGTC_1219 1469-0211 33.1 µM 0.679873565455313 0.243831142194635 no 836 0.248292260454376 1193 6822282 SGTC_1737 st035557 69.7 µM 0.678434483962534 0.244298727164755 no 837 0.248748125431326 1130 5716916 SGTC_194 1486-1323 56.904 µM 0.678071270240247 0.244416818558406 no 838 0.248863252839103 1202 5178754 SGTC_1805 st050013 60.3 µM 0.676900998519345 0.244797517212227 no 839 0.24923438526636 1187 4037144 SGTC_2584 androsterone 48.74 µM 0.676746093399936 0.244847932984032 no 840 0.249283532924916 1282 2754130 A steroid. SGTC_2360 9040895 200 µM 0.675811939057081 0.245152083406631 no 841 0.249580026772195 1187 4914414 SGTC_2614 arthonioic acid 13.39 µM 0.675232995318592 0.245340683077336 no 842 0.249763873325468 1185 6710684 SGTC_1188 1403-0014 4.57 µM 0.674547756803738 0.245564010617362 no 843 0.249981567219629 1256 9614867 SGTC_2980 9014342 25.29 µM 0.674490759476595 0.245582591655404 no 844 0.249999679274407 1235 2996599 SGTC_2995 9067767 71.4286 µM 0.672839749550037 0.246121145881761 no 845 0.250524623186905 1215 11673567 SGTC_1133 3473-0247 50 µM 0.671653214038482 0.246508580874203 no 846 0.250902246349346 1209 711311 SGTC_2744 captopril 92.04 µM 0.670439885260477 0.246905102238004 no 847 0.251288707989855 1208 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2266 7929956 200 µM 0.669891136420356 0.247084547896597 no 848 0.251463595226576 1243 2967153 SGTC_1724 st037281 8.293 µM 0.669883203273144 0.24708714261643 no 849 0.25146612400636 1250 574124 YDL195W SEC31 SGTC_1425 4048-4433 7.33 µM 0.669321561544699 0.247270877611524 no 850 0.251645187765193 1287 23734946 SGTC_2975 9084847 53.72 µM 0.66909897908749 0.247343713252444 no 851 0.251716170586892 1248 27211724 SGTC_613 3914-0030 117 µM 0.667427439897231 0.247891057155512 no 852 0.252249571698384 1052 1145395 SGTC_3029 9088683 49.47 µM 0.665393180245746 0.248558044666173 no 853 0.252899522873146 1243 25236615 SGTC_72 0744-0168 198.391 µM 0.662937020285285 0.24936463606909 no 854 0.253685445307659 1186 677577 SGTC_1482 3346-2049 8.48 µM 0.662199449256601 0.249607122293888 no 855 0.253921703564386 1246 3826804 SGTC_293 4049-0273 38.5 µM 0.66121477423622 0.249931042355147 no 856 0.254237293895318 1175 1380311 SGTC_61 0978-8327 98.565 µM 0.661024348740835 0.24999371072465 no 857 0.254298349374546 1272 6150059 YHR072W ERG7 SGTC_1120 ficusin 1.78878 µM 0.661022539318255 0.24999430623933 no 858 0.254298929560421 1308 6199 A DNA cross-linker. SGTC_3299 9121982 43.1275 µM 0.660989888471013 0.250005052370761 no 859 0.254309399075034 1261 17594604 YPL160W CDC60 SGTC_1160 4092-0570 10.5 µM 0.659885406381988 0.250368706712945 no 860 0.254663685005905 1248 4994975 SGTC_3353 9151644 39.2805 µM 0.658361801452717 0.250870818446635 no 861 0.25515283731883 1265 4909158 SGTC_1692 fluoroquinolonic acid 71 µM 0.657443728865126 0.251173631090749 no 862 0.255447820954241 1267 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_360 0957-0399 1.01 µM 0.657341784955097 0.251207267700198 no 863 0.255480587288983 1255 6752301 YPR165W RHO1 SGTC_285 1486-1325 46 µM 0.655306900764245 0.251879180102572 no 864 0.256135089350206 1272 22310230 SGTC_911 3456-4043 236 µM 0.654694621598683 0.25208153827281 no 865 0.256332194391404 1329 914281 SGTC_2934 9036370 36.88 µM 0.653455170771893 0.252491438969252 no 866 0.256731440533487 1252 6462800 SGTC_1273 0849-0096 14.1 µM 0.651906478119194 0.253004102674252 no 867 0.257230752799823 1261 5286025 SGTC_6 0844-0013 19.835 µM 0.651741994158724 0.253058583953713 no 868 0.257283813529972 1356 1584900 SGTC_1165 k072-0275 30.3 µM 0.651579048892765 0.253112561663436 no 869 0.257336383502973 1281 6153523 YGL055W OLE1 SGTC_2921 7974240 10.71 µM 0.65042680021279 0.253494431586344 no 870 0.257708285256893 1287 2979074 YDR527W RBA50 SGTC_2539 epi(13)torulosol 80 µM 0.650231117817338 0.253559313287751 no 871 0.257771471746228 1247 6708597 SGTC_1131 3454-3128 32.3 µM 0.649410802008381 0.253831397336398 no 872 0.25803644190457 1349 710982 SGTC_1939 st074455 53.6 µM 0.648985899340257 0.253972390163997 no 873 0.258173745203506 1315 1644229 SGTC_2440 5628896 157.78 µM 0.648822317908464 0.254026681333792 no 874 0.258226615100142 1289 5522048 SGTC_1194 1488-0194 225 µM 0.648672002942233 0.254076574853637 no 875 0.258275202191937 1253 1391452 SGTC_2367 9070478 135.38 µM 0.646957158169223 0.254646140917976 no 876 0.258829835602743 1259 572802 SGTC_676 falcarinol 140 µM 0.645812560493658 0.255026677720487 no 877 0.259200376277088 1328 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_78 0336-0123 156.75 µM 0.64564717481795 0.255081686988424 no 878 0.259253939254529 1189 6765896 SGTC_2221 6807166 181.081 µM 0.645447662041574 0.255148055599942 no 879 0.259318562488646 1237 674925 SGTC_3294 9122953 26.2835 µM 0.644063302139665 0.255608816294288 no 880 0.259767193052497 1267 16459826 SGTC_1420 4'-methoxyflavone 42 µM 0.642917618240394 0.255990466121493 no 881 0.260138778363905 1277 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3205 9113483 49.47 µM 0.6410133887188 0.256625459497076 no 882 0.260756992118753 1280 17018033 SGTC_3010 9080089 71.4286 µM 0.639021012145663 0.257290723839356 no 883 0.261404631365757 1308 17027233 SGTC_2233 sulbentine 40.3845 µM 0.637520993322365 0.257792178342977 no 884 0.26189276997978 1275 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.637096092878844 0.257934314190195 no 885 0.262031126697871 1323 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_943 3253-1379 105 µM 0.634912087520121 0.258665539209091 no 886 0.262742876563635 1310 668464 SGTC_2369 9071472 200 µM 0.634685527891067 0.258741454840832 no 887 0.26281676710856 1329 17296037 SGTC_2944 9067346 25.62 µM 0.634321200119593 0.258863558018991 no 888 0.262935611872591 1269 6473075 SGTC_2644 guaiazulene 100 µM 0.634257579746196 0.258884883221809 no 889 0.262956367838251 1294 3515 A coloring agent. SGTC_1016 4226-1401 38 µM 0.632381898784371 0.259514009431724 no 890 0.263568679549554 1292 2901613 SGTC_306 1672-3436 11.6 µM 0.632134161302524 0.259597162584079 no 891 0.26364960723645 1314 6797378 SGTC_717 1532-0246 73.2 µM 0.631685194110818 0.259747893589321 no 892 0.263796302347253 1277 9561992 SGTC_2421 5690543 90.72 µM 0.631312373487725 0.259873094350382 no 893 0.263918149024085 1329 3397993 SGTC_1085 doxorubicin 7.67 µM 0.631155619026297 0.2599257449873 no 894 0.263969388688531 1308 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2738 aclarubicin 5.55 µM 0.6306608932054 0.260091949410255 no 895 0.264131137172195 1238 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_463 ikarugamyin 104 µM 0.629207348803882 0.260580588200524 no 896 0.264606659188754 1341 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2076 5212012 200 µM 0.628715585113757 0.260746011587359 no 897 0.264767636510079 1210 604802 SGTC_3136 9095672 49.47 µM 0.625114010307284 0.261959182937542 no 898 0.265948116648872 1162 17217380 SGTC_916 4466-0038 42 nM 0.62413956377888 0.262287916806527 no 899 0.266267966534323 1351 5722064 YGL116W CDC20 SGTC_3211 9128781 49.47 µM 0.624104669236228 0.262299692553297 no 900 0.266279423841462 1309 17194361 SGTC_2994 9053520 71.4286 µM 0.621291168978643 0.263250045559861 no 901 0.267204031547576 1325 4647384 SGTC_795 0685-0265 78 µM 0.620195907307519 0.263620481508693 no 902 0.267564407842335 1341 302754 SGTC_758 0868-0029 16 µM 0.620165537492001 0.263630756880001 no 903 0.267574403978223 1316 762687 SGTC_1080 nisoldipine 24.4 µM 0.617133313092267 0.264657712098974 no 904 0.26857339863404 1284 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1478 0453-0656 35.7 µM 0.616433047949254 0.26489516710839 no 905 0.268804373695884 1323 5258496 SGTC_1641 st009299 47.1 µM 0.61618685289009 0.264978675849164 no 906 0.268885602233419 1267 4046054 SGTC_1132 3456-3614 2.5 µM 0.615767564409802 0.265120928224338 no 907 0.269023968833005 1407 3125502 SGTC_642 0335-0876 158 µM 0.613572639857011 0.265866234673043 no 908 0.269748883992982 1344 6812350 SGTC_695 3505-6186 243 µM 0.613099474894672 0.266027041111824 no 909 0.269905283704972 1334 1819379 SGTC_475 α-linolenic acid 10 µM 0.613092475021602 0.266029420408054 no 910 0.269907597780217 1391 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2098 5376439 882.5 nM 0.612212160941489 0.26632873000508 no 911 0.270198698338409 1376 2844116 SGTC_1403 3909-7815 62.9 µM 0.612152120611888 0.266349150114906 no 912 0.270218558076612 1306 6615483 SGTC_42 0133-0086 60.653 µM 0.606871091993451 0.268148356549664 no 913 0.271968231980933 1272 162923 Model of phenazepam hydroxylation. SGTC_123 0083-0120 66.675 µM 0.60673712124553 0.268194078794974 no 914 0.272012691421759 1275 16001701 SGTC_1587 estradiol valerate 56.1 µM 0.606400184543106 0.268309087671947 no 915 0.272124522978835 1320 13791 A steroid. SGTC_877 0771-0151 33.1 µM 0.606208704198957 0.268374458002724 no 916 0.272188086776427 1376 6166523 SGTC_1287 0971-0001 34.6 µM 0.606084730843641 0.268416786092132 no 917 0.272229244895453 1338 4665869 SGTC_2112 5488546 200 µM 0.60460723438916 0.268921504390649 no 918 0.272719999334935 1311 600757 SGTC_1444 4112-3581 28 µM 0.604335173583222 0.269014493297751 no 919 0.272810412902441 1350 2877249 SGTC_1874 staurosporine 7.6 µM 0.603442855598395 0.269319595973908 no 920 0.273107059946733 1368 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2909 7941780 10.49 µM 0.60133185784726 0.270042081577216 no 921 0.273809487358387 1349 1243215 SGTC_1818 st052136 56.3 µM 0.598746433085096 0.270928258241246 no 922 0.274670994109161 1261 674169 SGTC_3176 9106582 49.47 µM 0.598501543361047 0.271012271480044 no 923 0.274752664712825 1263 17018027 SGTC_1147 3809-1045 12.3 µM 0.596297982566106 0.271768821471533 no 924 0.275488089278163 1287 325925 SGTC_1078 idebenone 36.1 µM 0.595815699804866 0.271934544018876 no 925 0.275649177175984 1352 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2253 7938677 135.83 µM 0.595128869743165 0.272170640075782 no 926 0.275878666091948 1452 2301972 SGTC_2876 9059903 25.97 µM 0.592269419345378 0.273154662492649 no 927 0.276835095157611 1337 6916095 SGTC_1465 k213-0056 144 µM 0.591656035810509 0.273365975529518 no 928 0.277040471051764 1320 24048857 YMR208W ERG12 SGTC_2757 clomiphene 4.22 µM 0.591053611700888 0.273573591765375 no 929 0.27724225002198 1420 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_3178 9107506 49.47 µM 0.590292608057072 0.273835971504827 no 930 0.2774972471381 1372 8897194 SGTC_268 camptothecin 39.6153 µM 0.589992370367995 0.273939522030166 no 931 0.277597882312577 1371 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_641 4092-0595 30 µM 0.588104610459807 0.274591044387165 no 932 0.278231039352136 1375 786260 SGTC_3230 9131665 49.47 µM 0.586261434325319 0.275227916185093 no 933 0.278849921550945 1317 15943720 SGTC_2726 cimetidine 79.27 µM 0.586022958168764 0.275310369839677 no 934 0.278930043469854 1350 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2789 5281112 71.43 µM 0.584495697117474 0.275838711761544 no 935 0.279443429681007 1336 765948 SGTC_1503 4585-0012 61.3 µM 0.581972383633477 0.276712718890744 no 936 0.280292641383407 1403 2922052 SGTC_3108 9121785 49.47 µM 0.581167071984559 0.276991942286832 no 937 0.280563928876523 1369 17140271 SGTC_2016 5121758 140 µM 0.579479309499619 0.277577582400276 no 938 0.281132901797534 1332 2795203 SGTC_1572 epiandrosterone 68.9 µM 0.577301765718643 0.278334065424065 no 939 0.281867810548323 1327 441302 A steroid. SGTC_2717 st081029 62.2815 µM 0.577155481834628 0.278384920734441 no 940 0.281917213697417 1336 5292846 SGTC_786 4544-0069 423 µM 0.576047685082147 0.278770191069088 no 941 0.282291475348162 1428 748821 YLR208W SEC13 SGTC_1512 0259-0544 12.2 µM 0.575689227593348 0.278894911218662 no 942 0.282412628964386 1360 18476 SGTC_801 0866-0028 10.1 µM 0.575553646248955 0.278942091880982 no 943 0.282458460079731 1380 6849771 SGTC_2204 7233102 200 µM 0.575453328258075 0.278977003823387 no 944 0.282492373281936 1342 2172480 SGTC_1867 st057372 64 µM 0.573815715356151 0.279547214372269 no 945 0.283046256511737 1378 688837 SGTC_3219 9131112 49.47 µM 0.573271718831929 0.279736757009517 no 946 0.283230365538402 1332 17612988 YMR079W SEC14 SGTC_3096 9117468 49.47 µM 0.573171110299927 0.279771818488816 no 947 0.28326442156933 1299 41316311 SGTC_2515 chrysin 20.77 µM 0.572896292684854 0.27986760166934 no 948 0.283357457457487 1434 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_3090 9117696 49.47 µM 0.57269224878815 0.279938728115702 no 949 0.283426543310516 1438 7923821 SGTC_2809 7964133 12.99 µM 0.572220456502674 0.280103220934036 no 950 0.283586315204962 1410 1253665 SGTC_410 α-linolenic acid 100 µM 0.57154330800654 0.280339394090178 no 951 0.283815706120636 1400 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1825 st052143 62.6 µM 0.571491788079176 0.280357366952159 no 952 0.283833162654024 1425 674173 SGTC_2217 6934799 96.0675 µM 0.570781326123102 0.280605270355172 no 953 0.284073941381867 1376 675606 SGTC_620 0109-0052 432 µM 0.570104587549741 0.280841505153605 no 954 0.284303381922608 1396 493037 SGTC_2638 epoxomicin 18 µM 0.569510398594028 0.281049002909222 no 955 0.284504907950418 1418 9915668 A protesome inhibitor. SGTC_1280 0880-0253 10.1 µM 0.569181460844364 0.281163903674444 no 956 0.284616500310775 1373 6836607 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.568221753432045 0.281499267265658 no 957 0.284942201101817 1353 803109 SGTC_2841 9004761 38.96 µM 0.567053696542438 0.281907697428894 no 958 0.285338850199106 1293 2991039 SGTC_1241 0364-0022 50.8 µM 0.563898046356748 0.283012547404366 no 959 0.286411759852135 1452 4563895 SGTC_2238 6671620 73.2395 µM 0.563587387028387 0.283121427117339 no 960 0.286517486338636 1345 729941 SGTC_2475 5812728 15.03 µM 0.561340323353882 0.283909574693803 no 961 0.287282778857329 1365 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1007 4101-0031 70 µM 0.561171361328117 0.283968879793103 no 962 0.287340362088267 1425 1146276 SGTC_3193 9111931 49.47 µM 0.561106890114834 0.283991510533173 no 963 0.287362335688117 1425 17087244 SGTC_2846 9008642 19.48 µM 0.560798873553559 0.28409964267641 no 964 0.287467327351239 1390 2992898 SGTC_997 3996-0078 137 µM 0.560554643579957 0.284185395926684 no 965 0.287550589374955 1406 735687 SGTC_1792 st045773 43.6 µM 0.559764294337644 0.284462985634525 no 966 0.287820110577329 1375 2919270 SGTC_2786 7743617 45.45 µM 0.557845372741893 0.285137495673909 no 967 0.2884749883284 1316 583674 SGTC_768 0384-0033 77.3 µM 0.557098493829076 0.285400233096453 no 968 0.2887300682838 1377 3965305 YMR134W ERG29 SGTC_3343 9148379 18.9835 µM 0.556051619271022 0.285768697068859 no 969 0.289087783767209 1507 1955036 SGTC_2576 guaiol 23.12 µM 0.554031770119834 0.286480253480494 no 970 0.289778551626036 1433 227829 SGTC_3209 9113616 49.47 µM 0.55356631784679 0.286644343024265 no 971 0.289937841290375 1465 16649353 SGTC_595 3909-8003 73.7 µM 0.551481993872811 0.287379692274313 no 972 0.290651653358789 1431 699517 SGTC_1406 3909-7906 11.9 µM 0.549517782998361 0.28807348130172 no 973 0.29132508207148 1420 X1406 SGTC_775 4577-0580 57.3 µM 0.549120660741845 0.28821384690128 no 974 0.291461323679979 1471 2006902 SGTC_1912 st060209 90.8 µM 0.547856707140517 0.28866081463197 no 975 0.291895148741277 1369 688787 SGTC_501 nsc-95397 161 µM 0.546876770760102 0.289007570810665 no 976 0.292231697795732 1468 262093 SGTC_719 2810-4230 27.3 µM 0.545976744856673 0.289326222736133 no 977 0.292540961364535 1431 721079 SGTC_2386 9075165 157.42 µM 0.54485271382921 0.289724414807891 no 978 0.292927410188703 1389 16452277 SGTC_1485 3909-9022 254 µM 0.544481031637121 0.289856141129868 no 979 0.293055248929024 1411 714516 SGTC_297 0986-0032 24 µM 0.541568545135825 0.290889314446329 no 980 0.294057882832978 1383 2847425 SGTC_2507 purpurin 79.67 µM 0.540190402613182 0.291378794903159 no 981 0.294532865342633 1360 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1600 coumarin 106 71.1 µM 0.539849451958827 0.291499951000809 no 982 0.294650430000341 1459 100336 A hepatotoxic, DNA x-linker. SGTC_2957 9076800 11.52 µM 0.539068335326555 0.29177760769094 no 983 0.294919851744928 1382 16459615 SGTC_1408 3909-7976 48.8 µM 0.537325860831658 0.292397433486864 no 984 0.295521272525845 1453 24152374 SGTC_198 3454-2873 16.191 µM 0.536270901718605 0.292772996438717 no 985 0.295885668993765 1412 710957 SGTC_402 epigallocatechin gallate 10 µM 0.535146648118532 0.293173474424122 no 986 0.296274227638972 1421 65064 An antioxidant. SGTC_171 k064-0041 9.68 µM 0.534479067125802 0.293411398100206 no 987 0.296505064164323 1377 53325 SGTC_225 nsc-122657 1.016 µM 0.532851409540136 0.293991864536951 no 988 0.297068221636403 1431 275685 SGTC_896 0964-0007 44.5 µM 0.53281345397805 0.294005406843064 no 989 0.297081359814144 1421 6756758 SGTC_1698 5-fluorocytosine 1.055 µM 0.53218478530509 0.294229753812603 no 990 0.297299009791652 1470 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2025 5147754 141 µM 0.531139537417582 0.294602936364168 no 991 0.297661043909804 1471 315777 YLR208W SEC13 SGTC_3168 9103419 49.47 µM 0.53077800610811 0.294732063898622 no 992 0.297786311416217 1414 16649256 SGTC_1611 st001856 99.4 µM 0.530277387554056 0.294910912071284 no 993 0.297959811153069 1383 647478 SGTC_1155 4088-0394 48.2 µM 0.529620722819605 0.295145584224528 no 994 0.29818746176366 1401 2326248 SGTC_290 2043-6722 48.1 µM 0.528419675392119 0.295575024624687 no 995 0.298604042192439 1463 773758 YLR208W SEC13 SGTC_1374 2889-5571 141 µM 0.527378422066515 0.295947562180415 no 996 0.2989654124651 1436 2853281 SGTC_2237 6667747 47.222 µM 0.526512673272571 0.296257472116678 no 997 0.299266024474917 1460 729940 YDL015C TSC13 SGTC_1968 st069590 43.6 µM 0.524725448679439 0.296897710766486 no 998 0.299887031789617 1460 6384066 SGTC_3251 9135047 49.47 µM 0.523371702376611 0.297383085198294 no 999 0.300357806201634 1526 17682963 SGTC_2976 9009005 19.48 µM 0.52255924952895 0.297674557313421 no 1000 0.300640502418134 1584 2993148 SGTC_1104 tacrolimus 29.8 µM 0.520007686446022 0.298590791619924 no 1001 0.301529108883431 1470 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_487 nimodipine 119 µM 0.519608769294147 0.298734153627201 no 1002 0.301668142384781 1445 4497 L-type voltage-gated calcium channels inhibitor SGTC_3047 9092122 49.47 µM 0.519324381308818 0.298836375483042 no 1003 0.301767276948258 1412 17173831 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.51818226052111 0.299247065152463 no 1004 0.30216555527579 1476 4213774 SGTC_2524 avocatin b 10.57 µM 0.518011613372199 0.299308449315143 no 1005 0.302225083301134 1477 6710748 SGTC_2565 isoliquiritigenin 100 µM 0.517004393909663 0.299670876511637 no 1006 0.302576545785302 1377 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1663 st014140 55.4 µM 0.515911953802394 0.300064193196931 no 1007 0.302957952390536 1533 4207120 SGTC_1609 st001574 46.4 µM 0.515525422686177 0.300203413840175 no 1008 0.303092954573983 1422 3960012 SGTC_557 1315-0110 16.2 µM 0.51529922719081 0.300284898398739 no 1009 0.303171969453416 1413 6833801 SGTC_2608 thymoquinone 42.66 µM 0.514686072210007 0.300505831322009 no 1010 0.303386203794597 1388 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.514525138805755 0.300563831248492 no 1011 0.303442444604185 1444 279621 SGTC_1179 1021-1431 9.29 µM 0.513760021639106 0.300839646342689 no 1012 0.303709890993792 1471 2840958 SGTC_1905 st060207 84.5 µM 0.513279362046308 0.301012976436241 no 1013 0.303877959140956 1468 1948547 SGTC_1247 0448-0043 5.84 µM 0.511705549187501 0.301580822002504 no 1014 0.304428550918397 1473 3089013 YGL099W LSG1 SGTC_857 0438-0306 1.35 µM 0.509819317064247 0.302262025305282 no 1015 0.305089025578373 1480 4686136 SGTC_44 0929-0055 61.211 µM 0.509794201154212 0.302271100446945 no 1016 0.305097824344618 1413 1379590 SGTC_2650 prasterone 100 µM 0.509059139128981 0.302536754827119 no 1017 0.305355385855225 1452 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2663 amphotericin b 100 µM 0.50775280517928 0.303009127252805 no 1018 0.305813355580161 1455 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_710 3448-4187 58 µM 0.507662175569517 0.303041911302515 no 1019 0.305845139452338 1488 3946412 SGTC_444 curcumin 90.4 µM 0.506104435286956 0.303605650891293 no 1020 0.306391668556789 1477 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2408 sulbentine 18.36 µM 0.504962035617409 0.304019377832291 no 1021 0.306792750519643 1554 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_451 chloral hydrate 100 µM 0.503921910870169 0.304396283722088 no 1022 0.307158126357004 1509 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2697 mebhydrolin 72.4 µM 0.503511895598317 0.304544916471138 no 1023 0.307302209499253 1592 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1984 st072354 53.1 µM 0.503403761852658 0.304584120917634 no 1024 0.307340213651388 1479 5762938 SGTC_2438 5259590 200 µM 0.502641792996569 0.304860440272515 no 1025 0.307608070093974 1553 1201127 SGTC_124 0136-0217 7.121 µM 0.501349422835625 0.30532935813621 no 1026 0.308062614115124 1575 3976905 SGTC_598 3937-0236 20.2 µM 0.500986734075595 0.305461011989719 no 1027 0.308190229610079 1521 1379313 SGTC_3103 9120822 49.47 µM 0.499836537225231 0.305878692942023 no 1028 0.308595090652811 1542 17141819 SGTC_1814 st052110 31.539 µM 0.499726793832745 0.30591855822008 no 1029 0.308633731713319 1551 674163 SGTC_1479 0549-0158 134 µM 0.499605860493169 0.30596249101048 no 1030 0.308676315250536 1492 5440202 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.4991389347455 0.306132142479328 no 1031 0.308840755176317 1466 521171 SGTC_917 harmaline 728.087 nM 0.496983775110523 0.306915730546946 no 1032 0.30960024645651 1532 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2328 6201408 200 µM 0.495387616307478 0.307496642545832 no 1033 0.310163267237245 1459 2890418 SGTC_2176 5809774 33.9695 µM 0.494221881474343 0.307921209827511 no 1034 0.310574743971432 1518 2870539 SGTC_938 3126-1755 342 µM 0.493472237384556 0.308194370433843 no 1035 0.310839475850577 1515 1777771 SGTC_203 k066-0004 30.888 µM 0.493364649247981 0.308233582881889 no 1036 0.310877477933543 1547 6795412 SGTC_1334 1486-0610 236 µM 0.492406254276114 0.308582983853502 no 1037 0.311216089417291 1513 3742339 SGTC_3007 9078383 71.4286 µM 0.492143877706733 0.308678668428791 no 1038 0.31130881782319 1483 6496995 SGTC_201 4262-0159 12.803 µM 0.492042625242824 0.308715597071541 no 1039 0.311344605393068 1556 1341029 SGTC_1381 2324-0066 62.1 µM 0.491773148956904 0.308813889471862 no 1040 0.311439860170871 1516 10885928 SGTC_1128 3448-9350 235 µM 0.4902528975331 0.309368662812377 no 1041 0.311977476686501 1484 619386 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.489603777284495 0.30960567367654 no 1042 0.312207151521558 1424 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2991 9074669 71.4286 µM 0.487834952088501 0.3102519199707 no 1043 0.312833376021542 1592 17333109 SGTC_1934 st074720 32.6 µM 0.487790624900191 0.310268122598978 no 1044 0.312849076309114 1457 17250992 SGTC_778 3456-2434 196 µM 0.484601260800284 0.311434874998019 no 1045 0.313979609589483 1649 5539063 SGTC_335 4077-0256 27.6 µM 0.482063391638074 0.31236464932835 no 1046 0.314880457360503 1549 3121989 SGTC_711 k292-0785 179 µM 0.481535907893246 0.312558048709197 no 1047 0.315067832753915 1480 4146315 SGTC_2434 5670830 169.91 µM 0.480678516597068 0.312872517259441 no 1048 0.315372501092698 1511 1549830 SGTC_2400 5203494 178.7 µM 0.475575401064846 0.314747017516106 no 1049 0.317188451874499 1475 6777674 SGTC_3261 9137475 49.47 µM 0.474577648016228 0.315114077419814 no 1050 0.317544020539828 1499 17027690 SGTC_3318 9139014 38.6185 µM 0.474024939858532 0.315317489936892 no 1051 0.317741061320669 1511 16643984 SGTC_1402 3909-7673 35.9 µM 0.471780201510413 0.31614419327974 no 1052 0.318541842021444 1474 5328014 SGTC_2384 9036245 200 µM 0.471664364731842 0.316186879219223 no 1053 0.318583188308696 1598 6462766 SGTC_2214 7179297 48.276 µM 0.471584181476242 0.316216428243771 no 1054 0.318611809902159 1573 769744 SGTC_818 4072-2707 53.5 µM 0.471262206648221 0.316335093788371 no 1055 0.318726750438361 1458 882871 SGTC_649 1123-0311 367 µM 0.470515035689813 0.316610540502307 no 1056 0.318993547265277 1511 693629 YIL048W NEO1 SGTC_464 bw-b 70c 158 µM 0.470466019605146 0.316628613979658 no 1057 0.319011053013575 1582 5353454 SGTC_1784 st039334 36.3 µM 0.469218944031479 0.317088589633363 no 1058 0.319456572945137 1612 3496984 SGTC_2847 9005661 71.43 µM 0.468421634968443 0.317382820093516 no 1059 0.319741549695939 1489 2991449 SGTC_536 3852-0578 10.6 µM 0.468233323218137 0.317452329517967 no 1060 0.319808872228447 1618 2869208 SGTC_369 0957-0393 4.5 µM 0.468196681822366 0.317465855297573 no 1061 0.319821972427903 1479 6997992 SGTC_3094 9117742 49.47 µM 0.467418682667007 0.317753102870664 no 1062 0.320100179269577 1464 17149698 SGTC_1632 st005650 90 µM 0.467219293732199 0.317826737571667 no 1063 0.320171495597953 1532 2759605 SGTC_511 blebbistatin 171 µM 0.46667222362522 0.318028808566049 no 1064 0.320367202716161 1594 3476986 A myosin inhibitor. SGTC_1752 st044819 83.042 µM 0.46470120119767 0.318757293022933 no 1065 0.321072724020841 1453 441209 YML126C ERG13 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.464289192379716 0.318909659010944 no 1066 0.321220283053813 1468 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1981 st071826 47 µM 0.464270319511538 0.318916639165811 no 1067 0.321227042959684 1501 11838600 SGTC_1395 3486-0190 4.35 µM 0.463774003636221 0.31910022528542 no 1068 0.321404835211661 1648 6748079 SGTC_2940 9060638 45.86 µM 0.463425855548678 0.319229030961705 no 1069 0.321529574634433 1562 4027022 SGTC_47 0149-0135 24.25 µM 0.458515602542913 0.321048014450978 no 1070 0.32329102781349 1429 5239155 SGTC_1699 st031318 29.054 µM 0.456986654766691 0.321615287573665 no 1071 0.323840318833274 1597 5340658 SGTC_448 monastrol 171 µM 0.455852694808099 0.322036280452572 no 1072 0.32424795422959 1575 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1464 k208-0027 110 µM 0.455803368886602 0.32205459833569 no 1073 0.324265690675319 1626 X1464 SGTC_3277 9138724 49.47 µM 0.452491336809638 0.323285555763414 no 1074 0.325457530419138 1539 15943418 SGTC_1875 nocodazole 6 µM 0.451890464040458 0.323509085504709 no 1075 0.325673947259226 1583 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_735 3076-0345 636 µM 0.450705774262264 0.32394998666465 no 1076 0.326100810060367 1647 2888990 SGTC_2602 kawain 100 µM 0.447880559962783 0.325002431546218 no 1077 0.327119699496765 1532 5369129 SGTC_1141 3253-0389 52.6 µM 0.447418782242535 0.325174585479163 no 1078 0.327286358527977 1613 5402031 SGTC_249 wiskostatin 11.211 µM 0.445973488328337 0.325713642144627 no 1079 0.327808198335778 1623 2775510 A n-wasp and actin depolymerizer. SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.44537682637163 0.325936287785375 no 1080 0.328023728095964 1616 676296 Flavone; oxidizing agent. SGTC_1499 4480-0877 67.3 µM 0.444868736822143 0.326125931395137 no 1081 0.328207308368322 1561 2861909 SGTC_1325 1431-0015 227 µM 0.444835741932972 0.326138248240298 no 1082 0.328219231345398 1485 1103340 SGTC_1443 4112-3303 14 µM 0.443891246569621 0.326490904528308 no 1083 0.328560606747362 1560 704433 SGTC_2477 5967686 25.23 µM 0.443324704164696 0.326702514954821 no 1084 0.328765444736551 1498 776118 SGTC_1998 st075797 76.8 µM 0.443222351313642 0.326740750928942 no 1085 0.32880245672691 1633 24208315 SGTC_1278 0874-0585 172 µM 0.442256164671585 0.327101779074145 no 1086 0.329151923831895 1583 766306 SGTC_2331 7980721 200 µM 0.441995464807163 0.327199220694367 no 1087 0.329246243868787 1653 2981221 SGTC_3068 9116768 49.47 µM 0.441628231280747 0.327336501313493 no 1088 0.329379125742393 1537 41904888 SGTC_2045 5106652 78.05 µM 0.441214039608045 0.327491364029899 no 1089 0.329529025081448 1634 673349 SGTC_2050 5263056 171 µM 0.439392237063633 0.328172872554279 no 1090 0.33018867523721 1674 763468 YGL055W OLE1 SGTC_1229 0139-0193 12.2 µM 0.438881895735757 0.328363886175003 no 1091 0.330373557748402 1670 3090752 SGTC_1372 2752-0194 270 µM 0.436931067911832 0.329094467017909 no 1092 0.331080669969438 1509 823334 SGTC_1090 efavirenz 20.7 µM 0.436647850002456 0.329200585886916 no 1093 0.331183377511034 1610 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1820 st053765 18.6 µM 0.43645725801633 0.32927200651278 no 1094 0.331252501880918 1540 3690829 SGTC_1569 carminic acid 40.6 µM 0.434728959872427 0.329919936645795 no 1095 0.33187958754657 1642 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2232 chlorophetanol 41.5365 µM 0.433693387783906 0.330308412095354 no 1096 0.332255554426539 1670 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2747 doxorubicin 7.63 µM 0.432358665587332 0.330809377951497 no 1097 0.332740377531961 1574 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_633 0437-0093 97.7 µM 0.431698396504785 0.331057311148719 no 1098 0.332980316497073 1567 2831118 SGTC_256 clotrimazole 625 nM 0.430878613472319 0.331365245463398 no 1099 0.333278317325789 1590 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2829 7992743 58.44 µM 0.430753093920897 0.331412404325057 no 1100 0.333323954465438 1750 16462845 SGTC_900 1112-0045 141 µM 0.426357252728877 0.333065644181063 no 1101 0.334923772591476 1526 56211 YIL048W NEO1 SGTC_1677 st019204 53.9 µM 0.426015357884556 0.333194364639554 no 1102 0.335048327580392 1521 3945625 SGTC_2489 cantharidin 73.42 µM 0.425269198046117 0.333475355605724 no 1103 0.335320222484941 1541 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_714 4296-0578 26.1 µM 0.424411842467204 0.333798336361035 no 1104 0.335632742792619 1671 1589775 SGTC_782 0083-0095 30.5 µM 0.424348447101897 0.33382222339129 no 1105 0.335655855971504 1584 3591729 An indicator and reagent. SGTC_2404 5161160 200 µM 0.421890178474998 0.334749004249605 no 1106 0.336552589595359 1642 2831543 SGTC_2243 6634756 200 µM 0.421737863197324 0.334806461155418 no 1107 0.336608182217648 1697 885676 SGTC_2186 6124449 200 µM 0.42171558783339 0.334814864270894 no 1108 0.336616312665942 1635 3834182 YLR033W RSC58 SGTC_1534 6-azauridine 81.6 µM 0.420015452017063 0.33545646404175 no 1109 0.337237082821515 1590 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_36 0335-0881 14.2 µM 0.417509895913703 0.336402889374568 no 1110 0.338152743766509 1619 23828853 SGTC_968 1309-0633 340 µM 0.417329489628323 0.336471074470058 no 1111 0.338218710680562 1675 3761976 SGTC_1191 1487-1166 10.6 µM 0.417326266821826 0.33647229258832 no 1112 0.338219889169139 1679 3955771 SGTC_1717 st033143 58.0435 µM 0.414943393538684 0.337373411841943 no 1113 0.339091671239243 1728 674616 SGTC_472 calcifediol 10 µM 0.414292732535584 0.337619631536122 no 1114 0.339329867785412 1624 5283731 A vitamin D metabolite. SGTC_1843 st055809 45.5 µM 0.413841466023904 0.337790438259574 no 1115 0.339495106928784 1588 16413835 SGTC_570 0987-0065 62.6 µM 0.412848631167336 0.338166348999821 no 1116 0.339858759417675 1629 3104428 SGTC_863 0466-0191 129 µM 0.411617174600987 0.338632831779081 no 1117 0.340310020640234 1703 765160 YPR165W RHO1 SGTC_261 5-fluorouridine 15.376 µM 0.409613626970166 0.339392316093727 no 1118 0.341044699536301 1677 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1222 0366-0074 1.18 µM 0.40898224478473 0.339631789415117 no 1119 0.341276345552485 1737 286520 SGTC_1911 st060208 74.3 µM 0.408347643009516 0.339872549129188 no 1120 0.341509233077359 1699 688783 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.408115752730606 0.339960541607832 no 1121 0.341594347732317 1640 66535 A nucleotide analog. SGTC_2732 terfenadine 20 µM 0.404136789880802 0.341471743307562 no 1122 0.343056066288318 1636 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1831 st055328 12 µM 0.402495334221789 0.342095907681524 no 1123 0.343659760727138 1715 1103068 SGTC_2626 ethyl orsellinate 100 µM 0.401462025992695 0.342489045218596 no 1124 0.344039995470221 1594 75653 A natural product. SGTC_2065 5221596 34.26 µM 0.401341965282272 0.342534735185375 no 1125 0.344084185412825 1648 788581 SGTC_2149 5554786 194.827 µM 0.400669190400437 0.342790807120628 no 1126 0.344331848545901 1640 745063 YPR165W RHO1 SGTC_539 4859-0462 2.54 µM 0.397362492408478 0.34405045252993 no 1127 0.345550085103938 1759 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3129 9127257 49.47 µM 0.396856307004622 0.344243430808026 no 1128 0.345736712955074 1508 837894 SGTC_3131 9127911 49.47 µM 0.395073065032014 0.344923597396429 no 1129 0.346394483173607 1676 45595681 SGTC_465 cgp-37157 41 µM 0.394937681376416 0.344975256121592 no 1130 0.346444440016219 1720 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_408 cantharidin 100 µM 0.394107754084174 0.34529199695129 no 1131 0.346750743213568 1654 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1578 josamycin 24.2 µM 0.392739611054092 0.345814383756331 no 1132 0.347255905608014 1573 5282165 A P450 substrate. SGTC_2914 7968218 45.32 µM 0.392658347074297 0.345845421362519 no 1133 0.347285919432386 1726 2977111 SGTC_325 2810-4341 181 µM 0.392138697285695 0.346043918596723 no 1134 0.347477868153418 1753 774970 SGTC_1017 4239-0030 168 µM 0.391923475008779 0.346126142179231 no 1135 0.347557378616104 1557 1149593 SGTC_2402 5553605 200 µM 0.391921670091572 0.346126831761015 no 1136 0.347558045442553 1704 6758546 SGTC_2178 5812956 200 µM 0.389571683054234 0.347025093488337 no 1137 0.348426647318901 1659 5403383 SGTC_881 0833-0569 170 µM 0.385964719495481 0.348405495626825 no 1138 0.349761398931018 1571 5418700 SGTC_380 3970-0968 6 µM 0.384994109290577 0.348777296791077 no 1139 0.350120889949988 1621 2891601 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.3849047862778 0.348811520097429 no 1140 0.350153979832931 1601 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1772 st048439 82.2 µM 0.383974780743913 0.349167916359515 no 1141 0.350498569727671 1637 2927068 YDL195W SEC31 SGTC_700 3453-2283 142 µM 0.380659698805926 0.350439401056939 no 1142 0.35172788851015 1728 565664 SGTC_524 r073-0010 27.8 µM 0.379223965232793 0.350990591687373 no 1143 0.35226077833426 1617 2772106 SGTC_1331 1472-0049 76.2 µM 0.378455323857283 0.35128580880947 no 1144 0.352546188184016 1617 24051409 SGTC_3011 9081274 71.4286 µM 0.37760218062954 0.351613586203153 no 1145 0.352863072259983 1641 6625322 SGTC_2868 9035608 32.47 µM 0.377296008473474 0.35173124438143 no 1146 0.352976819079737 1607 6462614 SGTC_2647 atorvastatin 60.16 µM 0.376430401928617 0.352063963091783 no 1147 0.353298473896019 1720 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_993 3909-8757 62.7 µM 0.376226745216617 0.352142260393532 no 1148 0.353374166894039 1669 4288324 YLR208W SEC13 SGTC_3112 9123419 49.47 µM 0.373071055550197 0.35335628744824 no 1149 0.3545477801908 1691 17015854 SGTC_1367 1812-0510 76.9 µM 0.372338795710023 0.353638209478795 no 1150 0.354820308471376 1694 1142582 YDR527W RBA50 SGTC_1718 roemerine 11.9335 µM 0.372318675299071 0.353645957025921 no 1151 0.354827797820491 1657 235224 An aporphine alkaloid with mutagenic activity. SGTC_2670 beta-carotene 100 µM 0.371632629642624 0.353910161397187 no 1152 0.35508319571176 1694 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_846 0335-0850 148 µM 0.36642553869648 0.355917759951783 no 1153 0.357023782894089 1685 6819598 SGTC_843 0310-0051 143 µM 0.365245771216198 0.35637317844041 no 1154 0.357463977185474 1698 2065037 SGTC_950 1165-0508 94.1 µM 0.364496890685551 0.356662370613256 no 1155 0.357743497610828 1632 6148369 SGTC_3098 9119039 49.47 µM 0.364350378814436 0.356718958155722 no 1156 0.357798192246142 1674 17161528 SGTC_2616 abietic acid 100 µM 0.361860742828163 0.35768101589034 no 1157 0.358728048684574 1838 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_871 0574-0004 149 µM 0.361382658991347 0.35786586322126 no 1158 0.358906704732819 1681 9551173 SGTC_2407 paclitaxel 400 µM 0.360742144729605 0.358113565230056 no 1159 0.359146108088621 1781 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2301 7769476 200 µM 0.360185756875842 0.35832878205616 no 1160 0.359354112638821 1737 977820 SGTC_3114 9122766 49.47 µM 0.360181521820386 0.358330420394016 no 1161 0.35935569606626 1638 17176985 SGTC_371 0195-0006 7.36 µM 0.359893070434247 0.358442014402674 no 1162 0.359463549650154 1600 3928593 SGTC_1966 st070145 16.1 µM 0.358980299492003 0.358795220314011 no 1163 0.359804913540597 1641 3748532 SGTC_2948 9070189 9.45 µM 0.357631544077953 0.359317355838101 no 1164 0.360309534395347 1807 6473636 YDL196W YDL196W SGTC_934 2950-0684 338 µM 0.356682108639394 0.359685062726668 no 1165 0.360664900474655 1808 1121253 SGTC_3101 9120531 49.47 µM 0.356679846554238 0.359685938965002 no 1166 0.360665747298849 1784 24824904 SGTC_1453 4237-0541 195 µM 0.356415889323219 0.359788190154789 no 1167 0.360764565850759 1828 739892 SGTC_2273 7815444 169.05 µM 0.355993438882283 0.359951858989287 no 1168 0.360922739380413 1811 2824616 SGTC_3153 9100258 49.47 µM 0.355575555453599 0.360113783704417 no 1169 0.361079226338424 1645 25236848 SGTC_1605 st000082 49.1 µM 0.355090662686775 0.360301705178905 no 1170 0.361260835772793 1754 1114022 SGTC_1079 idarubicin 2.36 µM 0.354519880670358 0.360522956511267 no 1171 0.361474653827921 1759 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1202 1988-0068 29.6 µM 0.354230596947982 0.36063510894304 no 1172 0.361583037614081 1614 2850480 SGTC_2777 climbazole 1.536 µM 0.353531022242079 0.36090637665705 no 1173 0.361845187971561 1713 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_995 3931-2021 34.6 µM 0.353410389112199 0.360953160545678 no 1174 0.36189039916288 1725 730143 SGTC_1775 st081588 35.1725 µM 0.352613991494111 0.361262071301861 no 1175 0.362188923428607 1692 1426443 YGL099W LSG1 SGTC_3071 9117417 49.47 µM 0.352427386043651 0.361334465864685 no 1176 0.362258883351279 1816 45595590 YGL055W OLE1 SGTC_864 0469-0573 172 µM 0.351549098386055 0.361675268814287 no 1177 0.362588222394131 1670 689425 SGTC_3208 9114115 49.47 µM 0.351223850199552 0.361801503096216 no 1178 0.362710209308225 1600 650895 SGTC_93 0109-0045 59.227 µM 0.350891792215488 0.36193039588964 no 1179 0.362834764667552 1763 88733 SGTC_2026 5148700 152 µM 0.350258893379631 0.362176107488423 no 1180 0.363072205985132 1687 79838 SGTC_660 4031-1742 102 µM 0.350092143623229 0.362240854543185 no 1181 0.36313477337682 1696 6738706 SGTC_2844 9010103 25.97 µM 0.34740092684678 0.363286367705518 no 1182 0.364145068564717 1699 2480525 SGTC_1299 1079-1439 3.74 µM 0.346085073690016 0.363797936212593 no 1183 0.364639390290445 1657 323161 SGTC_1705 st027868 56.3335 µM 0.34441918878035 0.364445936016848 no 1184 0.365265530038814 1806 292948 SGTC_1933 st074711 15.9 µM 0.344387350836331 0.364458324195008 no 1185 0.365277500157649 1674 17250958 SGTC_745 0469-0705 296 µM 0.343158831677076 0.364936450330779 no 1186 0.365739486916278 1826 3486736 SGTC_2476 5806916 10.51 µM 0.343102661003303 0.364958316366946 no 1187 0.365760614657226 1751 2870194 SGTC_163 TUB2.036 7.546 µM 0.343005768983193 0.364996035380241 no 1188 0.36579706006753 1760 15992207 YJR013W GPI14 SGTC_927 2425-1185 123 µM 0.342791488375325 0.365079457137375 no 1189 0.365877664862455 1642 730375 SGTC_3300 9124615 50.48 µM 0.341593409230701 0.36554599986688 no 1190 0.366328448920767 1785 24824903 SGTC_541 4513-1321 94 µM 0.34154161866672 0.365566172067148 no 1191 0.366347939578372 1666 747515 SGTC_634 1611-4317 11.2 µM 0.340884757294652 0.365822048970622 no 1192 0.366595170109532 1829 2843522 SGTC_3147 9097027 49.47 µM 0.339523429944405 0.366352536871753 no 1193 0.3671077248323 1785 25236841 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.339040386305105 0.366540832861027 no 1194 0.367289653077408 1782 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1451 4152-0210 104 µM 0.337614910020579 0.367096687125141 no 1195 0.367826702360251 1831 659563 SGTC_151 3013-0144 2.285 µM 0.335070782244087 0.368089443468924 no 1196 0.368785846266566 1823 906558 YHR107C CDC12 SGTC_2936 9038235 15.59 µM 0.334502640616794 0.368311261400868 no 1197 0.369000149312383 1698 4749415 SGTC_1751 st044839 27.194 µM 0.333251275223453 0.368799983206088 no 1198 0.369472307959618 1774 5291326 SGTC_2103 5378138 10 µM 0.33313875135538 0.368843939909443 no 1199 0.369514774537666 1772 244142 SGTC_1348 1493-0373 93.8 µM 0.332132640164807 0.369237046770702 no 1200 0.369894552225003 1753 3010129 SGTC_422 cantharidin 155 µM 0.33097035516133 0.36969134398635 no 1201 0.370333438970121 1639 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_438 sphingosine 6.67 µM 0.327874168201027 0.370902423355213 no 1202 0.371503402923272 1571 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1521 st012942 49.4 µM 0.326853691111527 0.371301865940424 no 1203 0.37188927402817 1903 24207259 SGTC_1665 st014639 11.4 µM 0.326640160238226 0.371385465309327 no 1204 0.371970032358294 1805 981133 YIL048W NEO1 SGTC_1834 st055981 52.8 µM 0.326075283210409 0.371606649289621 no 1205 0.372183698525617 1853 471719 YDL150W RPC53 SGTC_54 0159-0055 9 µM 0.32488347444013 0.372073454481778 no 1206 0.372634632264376 1856 3319099 SGTC_2189 6047310 154.431 µM 0.323636619117157 0.372562021507744 no 1207 0.373106580372318 1746 711535 SGTC_956 1185-0240 191 µM 0.323082201730058 0.372779330008322 no 1208 0.373316494516642 1760 1416193 SGTC_416 estradiol valerate 100 µM 0.322423545434334 0.373037548441713 no 1209 0.373565924584325 1774 13791 A steroid. SGTC_2522 biochanin a 4.94 µM 0.32185980815319 0.373258600306651 no 1210 0.373779451342183 1798 5280373 A possible chelator. SGTC_191 3914-0123 66.505 µM 0.321767589892458 0.37329476477311 no 1211 0.373814384540026 1707 3144412 SGTC_460 trequinsin 123 µM 0.321265561158198 0.373491660766362 no 1212 0.374004576211486 1773 5537 A vasodilator. SGTC_1554 st069299 38.7 µM 0.321105186897069 0.373554566618688 no 1213 0.37406533985608 1801 24207999 SGTC_1053 3366-3204 134 µM 0.320783278152358 0.373680843581084 no 1214 0.374187316180844 1682 3632071 YPR165W RHO1 SGTC_2372 9071633 200 µM 0.320473030928391 0.373802558847242 no 1215 0.3743048856908 1842 21321366 SGTC_1256 0570-0116 285 µM 0.320292667160967 0.373873324409037 no 1216 0.374373240684573 1693 410638 SGTC_1907 st060210 83.7 µM 0.320252445992094 0.373889105728286 no 1217 0.37438848440522 1835 688793 SGTC_906 1165-0455 526 µM 0.31810736676749 0.374731062221384 no 1218 0.375201747895653 1703 3252859 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.313803098927989 0.376422311991863 no 1219 0.376835295294891 1911 5024745 SGTC_1284 0929-0043 16 µM 0.313324047160599 0.376610690366132 no 1220 0.377017241135998 1747 1239883 SGTC_650 1328-0195 38 µM 0.312785032892873 0.376822683033428 no 1221 0.377221993634357 1869 2780821 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.311882103561296 0.377177885583307 no 1222 0.377565061949884 1865 77254 SGTC_2896 9052656 71.43 µM 0.311076304136412 0.377494966076601 no 1223 0.377871307323195 1780 6469436 SGTC_1328 1441-0025 69.2 µM 0.310632487434144 0.37766964236346 no 1224 0.378040013377374 1661 4562601 SGTC_3162 9099653 49.47 µM 0.310462230681923 0.377736658239833 no 1225 0.378104738488301 1849 25237511 SGTC_2163 5671233 125 µM 0.310360075147906 0.377776870115999 no 1226 0.378143575760906 1871 701023 SGTC_2870 9038528 12.99 µM 0.310274140552671 0.377810697907375 no 1227 0.37817624714528 1740 6463316 SGTC_902 1120-0002 2.07 µM 0.309595266818595 0.378077966615072 no 1228 0.37843437805049 1729 3280475 SGTC_1882 5615643 20 µM 0.308735992055693 0.378416341846719 no 1229 0.378761181356837 1808 2253075 SGTC_1637 st007924 17.4 µM 0.308723747573423 0.378421164296165 no 1230 0.378765838861428 1737 683336 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.30797823074659 0.378714819318205 no 1231 0.3790494485579 1781 364106 SGTC_2461 5755302 26.15 µM 0.306850524993249 0.379159149528738 no 1232 0.379478574376773 1880 2788904 SGTC_3324 9138759 60.749 µM 0.306601283048483 0.379257375550142 no 1233 0.379573438460046 1791 45595710 SGTC_930 2810-3379 265 µM 0.306447318386067 0.379318056777668 no 1234 0.379632042638792 1906 1015764 SGTC_543 3844-1095 191 µM 0.30530957064017 0.379766562982442 no 1235 0.380065193697352 1851 4230703 SGTC_3139 9095020 49.47 µM 0.305226991050237 0.379799122600338 no 1236 0.380096638372578 1732 25236292 SGTC_1253 0550-0034 176 µM 0.303326318075817 0.380548758185014 no 1237 0.38082059572739 1770 5969915 SGTC_2773 thioridazine 9.09 µM 0.303116235359326 0.380631643524445 no 1238 0.380900640908171 1813 5452 An antipsychotic. SGTC_2888 9058547 12.99 µM 0.302467177763421 0.38088775515962 no 1239 0.381147975365872 1718 16476514 SGTC_1515 3460-0031 42.1 µM 0.302166561162906 0.381006393156144 no 1240 0.381262546904452 1837 2876596 SGTC_1156 4092-0367 4.88 µM 0.300318036320382 0.381736156859318 no 1241 0.381967288421881 1793 1357585 SGTC_291 SEC14.278 35.5 µM 0.300147084297855 0.381803666864563 no 1242 0.382032482889814 1871 1068044 SGTC_1466 k213-0079 57.5 µM 0.299567898942952 0.382032417434623 no 1243 0.382253386565999 1773 3657981 SGTC_3124 9127567 49.47 µM 0.299422512465427 0.382089844624132 no 1244 0.382308843587632 1878 17592030 SGTC_3107 9121808 49.47 µM 0.298656091765309 0.382392621183881 no 1245 0.382601231219481 1897 662681 SGTC_1397 3532-0190 20.1 µM 0.298533027827877 0.38244124462914 no 1246 0.382648186052849 1813 5322280 SGTC_2591 skatole 100 µM 0.297975994151473 0.382661355806157 no 1247 0.38286074285923 1777 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2146 5545642 200 µM 0.297962275691307 0.382666777117512 no 1248 0.382865978090637 1828 825326 SGTC_1618 st003135 44.5 µM 0.297914385871533 0.382685702572182 no 1249 0.382884253945701 1882 1270615 SGTC_2426 5582046 32.21 µM 0.296792619480193 0.383129090590735 no 1250 0.383312420267858 1824 2251934 SGTC_1345 1488-0192 31.4 µM 0.296321073277401 0.383315519124303 no 1251 0.383492447038411 1889 658348 SGTC_1337 1486-1011 40.3 µM 0.2959029631982 0.383480843980646 no 1252 0.383652094024653 1819 X1337 SGTC_1803 st050068 52.4 µM 0.295633387098334 0.383587448285985 no 1253 0.383755036751349 1806 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_312 4092-0653 6.84 µM 0.295026909764442 0.383827312933631 no 1254 0.383986661560401 1873 1148278 SGTC_1745 st081495 74 µM 0.294883152058802 0.383884176314679 no 1255 0.384041571342534 1805 13842402 YBL026W LSM2 SGTC_2605 digitonin 300 nM 0.294879010858291 0.383885814404187 no 1256 0.38404315315254 1943 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2074 5212007 75.395 µM 0.293785554731335 0.384318413427012 no 1257 0.384460886954645 1925 758611 SGTC_1182 1222-0449 220 µM 0.29359175574591 0.384395100280529 no 1258 0.384534938130259 1815 658318 SGTC_3227 9130768 49.47 µM 0.292314011899592 0.38490082057505 no 1259 0.385023273249608 1846 17720899 SGTC_3273 9137859 49.47 µM 0.292192358688387 0.384948980120993 no 1260 0.385069776860819 1844 2377234 SGTC_2472 5377652 49.4 µM 0.292151103142166 0.384965312590874 no 1261 0.385085547735497 1768 1610903 SGTC_2572 astragaloside iv 100 µM 0.291758995529694 0.385120552468425 no 1262 0.385235449310076 1799 45006101 An anti-inflammatory agent. SGTC_322 k048-0136 19.3 µM 0.291323472346979 0.385293002649433 no 1263 0.385401968630506 1828 6823282 SGTC_616 4092-0450 108 µM 0.290395317286659 0.385660591471868 no 1264 0.385756912850322 1826 787165 SGTC_384 k007-0144 5.16 µM 0.289394085555258 0.38605723691757 no 1265 0.386139910254672 1816 6824886 SGTC_1316 1272-0050 65.9 µM 0.287039126214998 0.386990640654383 no 1266 0.387041180894778 1805 7340392 SGTC_2370 9071495 200 µM 0.286911887857616 0.387041091088644 no 1267 0.387089893905379 1770 21791103 SGTC_653 0203-0016 55.2 µM 0.286755444845806 0.387103123881689 no 1268 0.38714979031068 1832 295302 SGTC_3005 9076496 71.4286 µM 0.285717352635729 0.387514821248756 no 1269 0.3875473065082 1897 21368410 SGTC_954 1189-0853 2.85 µM 0.284645728651535 0.387939949712606 no 1270 0.387957786705119 1863 2828194 SGTC_1853 st056710 91.2 µM 0.284214713558422 0.388110977438137 no 1271 0.388122920214199 1967 269167 SGTC_1329 1447-1697 50.6 µM 0.283982177022487 0.388203257455856 no 1272 0.388212019637139 1829 2840515 SGTC_485 niflumic acid 177 µM 0.283377654455324 0.388443186282609 no 1273 0.388443677906019 1855 4488 A COX2 inhibitor. SGTC_3181 9108277 49.47 µM 0.281483156104829 0.389195368680828 no 1274 0.389169922759739 1788 17097298 SGTC_314 1671-0008 2.74 µM 0.281278080488639 0.389276815872366 no 1275 0.389248560576232 1837 3913060 SGTC_606 k015-0008 38.6 µM 0.280255200590285 0.389683132238276 no 1276 0.389640859390644 1923 1970475 SGTC_861 0443-0273 110 µM 0.280120261441565 0.389736742837802 no 1277 0.389692620175341 1872 6149169 SGTC_2925 9010536 32.5 µM 0.279782082698711 0.389871108652514 no 1278 0.389822349441871 1865 2994177 SGTC_3250 9135583 49.47 µM 0.278128279227349 0.390528390243615 no 1279 0.390456944069604 1909 7699353 SGTC_2529 gangaleoidin 93.61 µM 0.277702444377599 0.390697683228204 no 1280 0.390620392017821 1814 4565183 SGTC_1764 st044502 93.5 µM 0.277041891523112 0.39096033063471 no 1281 0.390873969882136 1812 8407 SGTC_1917 st066507 28.5 µM 0.276729871333016 0.391084412643228 no 1282 0.390993766621136 1770 3156428 SGTC_2197 6588183 93.1375 µM 0.276565992956264 0.391149587092444 no 1283 0.391056690075282 1870 884136 SGTC_378 3970-0959 8.33 µM 0.275420945821474 0.391605057668652 no 1284 0.391496426846056 1866 6615653 SGTC_1158 4092-0494 91.8 µM 0.274697127374153 0.391893050920983 no 1285 0.391774469159122 1896 1148199 SGTC_2403 6032726 181.2 µM 0.274325946550335 0.392040759526555 no 1286 0.391917073294746 1796 2881040 SGTC_506 n9-isopropylolomoucine 153 µM 0.273522369032453 0.392360590410866 no 1287 0.392225849844575 1994 6610355 SGTC_1681 tripelennamine 100 µM 0.272248120507204 0.392867901482468 no 1288 0.392715621913609 1816 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2679 rapamycin 1 nM 0.272143859993267 0.39290941833933 no 1289 0.392755703171729 1841 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2286 7945697 125 µM 0.270728312798854 0.393473213949969 no 1290 0.393299999630892 1755 1245733 SGTC_3296 9122258 64.045 µM 0.270506519850576 0.393561571720036 no 1291 0.393385300859105 1834 4730474 SGTC_2728 chlorpromazine 9.18 µM 0.269999015452238 0.393763771696415 no 1292 0.393580505520773 1865 2726 A thorazine and dopamine antagonist. SGTC_2709 st078560 56 µM 0.269776207276499 0.393852552014603 no 1293 0.393666214106688 1939 17250903 SGTC_1940 st075990 51.1 µM 0.268322013782729 0.394432126395364 no 1294 0.394225731379549 1894 1084979 SGTC_391 gliotoxin 8.33 µM 0.265315658078043 0.39563106089066 no 1295 0.395383151607779 1885 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_3213 9129884 49.47 µM 0.264771181802513 0.395848304036114 no 1296 0.395592869198255 1733 17190742 SGTC_1806 st050005 60.3 µM 0.264418848164149 0.395988900536849 no 1297 0.395728594739006 1790 5194765 SGTC_3217 9129673 49.47 µM 0.263412034295157 0.396390737741374 no 1298 0.396116508009867 1845 17248312 SGTC_3056 9094900 49.47 µM 0.261851378645265 0.397013840429391 no 1299 0.396718013080902 1745 25236784 SGTC_1832 st054113 55 µM 0.261709125326112 0.397070649164556 no 1300 0.396772852344248 1970 1251267 SGTC_2756 carbadox 75.1 µM 0.260881100761352 0.397401363348963 no 1301 0.397092099853707 1821 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_3031 9088762 49.47 µM 0.260105593743942 0.397711168855938 no 1302 0.397391161606431 1851 205253 SGTC_1652 st011932 78 µM 0.259821465044862 0.397824690934057 no 1303 0.397500746359077 1934 1551076 SGTC_1938 st074717 56.4 µM 0.256688425868568 0.399077051387523 no 1304 0.398709653537206 1826 17250979 SGTC_3170 9103054 49.47 µM 0.256659758027666 0.399088515517503 no 1305 0.398720719750738 1840 16432970 SGTC_2751 anetholtrithion 17.25 µM 0.256128608325548 0.399300935432609 no 1306 0.398925766166863 1950 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1096 rimcazole 32.2 µM 0.254945834761528 0.399774062904501 no 1307 0.399382467305743 1842 18528119 A dopamine reuptake inhibitor. SGTC_3069 9117009 49.47 µM 0.254814745874081 0.399826509532852 no 1308 0.399433092790871 1973 41904981 SGTC_3333 9141820 12.094 µM 0.253732250914135 0.400259667952947 no 1309 0.399851208294599 1822 1939433 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.253719632796626 0.400264717794677 no 1310 0.399856082741875 1746 641818 YHR062C RPP1 SGTC_2270 7924575 90.91 µM 0.252404825035391 0.400791002508095 no 1311 0.400364085510837 1999 1262135 SGTC_3256 9138902 49.47 µM 0.251857584300467 0.401010102449613 no 1312 0.400575572861497 1933 17228773 SGTC_2945 9067681 61.76 µM 0.251220391866933 0.401265255777075 no 1313 0.40082185978774 1903 16456930 SGTC_2813 7971799 71.43 µM 0.250647188003476 0.401494821908578 no 1314 0.401043447611535 1867 2234054 SGTC_2433 5607874 27.82 µM 0.25058060018324 0.401521492302338 no 1315 0.401069191042493 1810 2252428 SGTC_3264 9137442 49.47 µM 0.250046839667041 0.40173529576153 no 1316 0.401275563017278 1958 17015726 SGTC_720 r052-1644 49.9 µM 0.249970002834435 0.4017660759966 no 1317 0.401305273308085 1857 1422863 YOR257W CDC31 SGTC_2086 5274770 176.623 µM 0.249531416416255 0.401941781951618 no 1318 0.401474871255369 1856 689278 SGTC_2387 9077560 195.08 µM 0.247832346371218 0.40262264813375 no 1319 0.40213206335374 1840 5303272 SGTC_2897 9048598 12.99 µM 0.247141336132509 0.402899640425156 no 1320 0.402399422058616 1851 6467404 SGTC_3040 9091894 49.47 µM 0.246762566959259 0.403051491196349 no 1321 0.402545990985132 1945 25236966 SGTC_2953 9074162 66.49 µM 0.245670715070112 0.403489302740362 no 1322 0.402968571762447 2031 16451992 SGTC_1178 0988-0033 191 µM 0.244755361663617 0.403856435046099 no 1323 0.403322929494076 1930 5392207 SGTC_2999 9069765 71.4286 µM 0.244232014251842 0.404066378661551 no 1324 0.403525566936661 1919 2097066 SGTC_2385 9074692 200 µM 0.244068906606619 0.404131815817857 no 1325 0.403588726679959 1844 17046906 SGTC_3113 9123498 49.47 µM 0.242816828360415 0.404634226294783 no 1326 0.404073649254056 2016 8897275 SGTC_622 1348-1566 26.3 µM 0.242614254891532 0.404715525979925 no 1327 0.404152118649214 1940 7340407 SGTC_2531 methyl deoxycholate 70.07 µM 0.242392807901876 0.404804404962913 no 1328 0.404237903353595 1842 16667744 Haematoxylin. SGTC_2062 5245942 200 µM 0.242217412141455 0.404874804514308 no 1329 0.404305851882531 1954 1376160 SGTC_1193 1488-0126 41.5 µM 0.241827307037673 0.405031394160154 no 1330 0.404456989417405 1846 1384710 SGTC_3115 9123671 49.47 µM 0.241360069886374 0.405218964909969 no 1331 0.404638028810769 2019 3286988 SGTC_2600 tangeritin 87.95 µM 0.241015252014136 0.405357404826427 no 1332 0.404771647760362 1824 68077 A bioactive flavone. SGTC_1846 st056244 14.8 µM 0.240626465294069 0.405513511868905 no 1333 0.404922318215215 1917 5393182 SGTC_1265 0819-1001 68.8 µM 0.239983116648942 0.405771864534237 no 1334 0.405171672582852 1910 3106768 SGTC_3322 9139058 2.11 µM 0.239973250750926 0.405775826751057 no 1335 0.405175496788868 1952 4908926 YPR165W RHO1 SGTC_1286 0929-0070 131 µM 0.238885712319352 0.406212649233706 no 1336 0.4055971023905 1943 1420408 SGTC_621 3584-0052 32.1 µM 0.238728009033452 0.406276002302604 no 1337 0.40565824826763 2004 2273927 SGTC_1164 k060-0068 93.7 µM 0.238600882644916 0.406327073708792 no 1338 0.405707540321267 1899 5963676 SGTC_833 3852-0053 558 µM 0.23830947467267 0.40644414915958 no 1339 0.405820536644357 1927 3123681 SGTC_1034 k072-0165 12.7 µM 0.236854437867469 0.407028846615152 no 1340 0.406384858788245 2011 5835461 SGTC_1037 k284-1091 78.7 µM 0.235943867189348 0.407394859281082 no 1341 0.406738113965064 1835 3334711 SGTC_2158 5657123 3.6195 µM 0.233628759355276 0.408325802665838 no 1342 0.407636599399723 1993 2858827 SGTC_346 4513-0042 7.16 µM 0.232490638138666 0.408783650265424 no 1343 0.408078478859926 1859 2827372 SGTC_1633 st005664 67.9 µM 0.232250009404197 0.40888046724551 no 1344 0.408171918783916 1869 2063822 SGTC_250 brefeldin a 552.239 µM 0.231386776181542 0.409227834874277 no 1345 0.408507168761328 1901 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_674 0498-0004 451 µM 0.230514670103666 0.409578845360538 no 1346 0.408845932654357 1847 4231473 SGTC_572 0960-0087 17.7 µM 0.229969371820733 0.409798357137033 no 1347 0.409057784823068 1839 6796365 SGTC_3304 9125678 46.087 µM 0.229778822419884 0.40987507015077 no 1348 0.4091318208554 1869 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3234 9132280 49.47 µM 0.228573896471956 0.410360239347611 no 1349 0.409600057536838 1906 17612295 SGTC_2819 7996655 46.38 µM 0.227342021287864 0.410856401645084 no 1350 0.410078900077717 1984 6456960 SGTC_817 1391-0715 46 µM 0.227141479249897 0.410937187473922 no 1351 0.410156865540914 1860 1353946 SGTC_1865 st057639 52.2 µM 0.226899181923617 0.411034798932789 no 1352 0.410251069098035 1991 688818 SGTC_1113 artemisinin 1.17947 µM 0.22688786443775 0.41103935840921 no 1353 0.410255469386429 2026 2240 An anti-malaria and mitochondrial poison. SGTC_1613 st002381 52.1 µM 0.226879844401758 0.411042589449017 no 1354 0.410258587618617 2042 551167 SGTC_2441 5730946 39.09 µM 0.225945712711909 0.411418965235799 no 1355 0.41062182170155 1964 1774275 SGTC_3062 9077494 49.47 µM 0.225800721496227 0.411477391708221 no 1356 0.410678207947912 1969 16459633 SGTC_2898 9056270 58.44 µM 0.225780252515583 0.41148564016148 no 1357 0.410686168364994 1924 19154699 SGTC_1877 wortmannin 25 µM 0.225349475443607 0.41165924090186 no 1358 0.410853706739646 2015 312145 A covalent inhibitor of PI 3-kinase. SGTC_2974 9094440 9.66 µM 0.224454551253033 0.412019945571134 no 1359 0.411201813769217 1962 25236134 SGTC_3246 9135460 32.98 µM 0.223872396340609 0.41225462659971 no 1360 0.411428297566401 1969 41446951 SGTC_1009 4106-0057 9.87 µM 0.22277777811254 0.41269597915935 no 1361 0.411854231949176 2048 2928005 SGTC_1154 4088-0362 150 µM 0.221844530346598 0.413072353990226 no 1362 0.412217456424185 1902 6618304 SGTC_955 1216-0110 33 µM 0.221129659885092 0.413360712259323 no 1363 0.412495738297684 1868 3619719 SGTC_3067 9117431 49.47 µM 0.221025438874819 0.413402755937264 no 1364 0.41253631270751 1877 17150885 SGTC_928 2764-0428 58.7 µM 0.220080201239831 0.413784118450737 no 1365 0.412904346963085 1936 662578 SGTC_2715 st079500 56.4 µM 0.218896800022626 0.414261684282792 no 1366 0.413365219618414 1885 28246688 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.218767669791149 0.414313802938797 no 1367 0.413415516301589 2059 688664 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.218445299990137 0.414443922204262 no 1368 0.413541086682064 1887 75037 A free radical scavenger. SGTC_661 1304-0007 33.6 µM 0.21767670571752 0.414754190490731 no 1369 0.413840507310619 1900 3117130 SGTC_1573 oleylamine 1.06 µM 0.217656574875103 0.414762317681134 no 1370 0.413848350340086 1878 5356789 An amine of the fatty acid oleic acid. SGTC_1866 st057638 64 µM 0.217275822323078 0.414916041338751 no 1371 0.413996699010121 1905 688802 SGTC_186 3455-3465 67.277 µM 0.216740630575665 0.41513213974089 no 1372 0.414205240968311 1950 755278 SGTC_2893 9048488 25.97 µM 0.21640569544881 0.41526739208703 no 1373 0.414335763563733 1848 6467338 SGTC_469 w7 172 µM 0.214476561274837 0.416046603387397 no 1374 0.415087721544502 1995 45115570 A P450 inhibitor. SGTC_1003 4049-0218 100 µM 0.210934151033523 0.417478302921595 no 1375 0.41646932747167 1984 295161 SGTC_1257 0669-0121 16 µM 0.210097592332627 0.417816566740758 no 1376 0.416795752292755 2018 4307855 SGTC_2348 9022543 33.42 µM 0.208474247134897 0.418473142199116 no 1377 0.417429344346985 1937 3162678 YDL140C RPO21 SGTC_2470 5664817 21.68 µM 0.206493940248376 0.419274401267961 no 1378 0.418202548865113 2015 2859561 SGTC_19 0279-0214 38.434 µM 0.206440992974475 0.419295829065616 no 1379 0.418223226313276 1973 3566274 YBR002C RER2 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.206312784135092 0.419347716261246 no 1380 0.418273296524661 2040 688662 SGTC_765 1319-0117 244 µM 0.205255301057305 0.419775741969246 no 1381 0.418686332540583 1939 3487746 YGL099W LSG1 SGTC_1513 0337-0559 19 µM 0.204588578781591 0.420045652579334 no 1382 0.418946789735638 1878 775073 SGTC_2427 5545055 42.75 µM 0.204566241488771 0.420054696085358 no 1383 0.418955516486448 1959 5372858 SGTC_2801 7907800 81.82 µM 0.204237750478167 0.420187694264289 no 1384 0.419083856211128 1931 6620925 SGTC_165 k038-0023 64.381 µM 0.203958579074709 0.420300731274804 no 1385 0.419192933791517 1940 46368543 SGTC_1712 st032288 53.4 µM 0.203407849515236 0.420523741944569 no 1386 0.41940813251571 1967 2883011 SGTC_1523 st012844 44.7 µM 0.201526597048321 0.421285722312844 no 1387 0.420143417293493 1946 4274103 SGTC_2714 st079313 56.9 µM 0.201468984750716 0.42130906220093 no 1388 0.420165939388593 1936 2939799 SGTC_872 0588-0139 234 µM 0.200999142641889 0.421499414903288 no 1389 0.420349622230189 1977 2047100 SGTC_1685 st024049 53.0905 µM 0.200610439429515 0.421656908712596 no 1390 0.420501597267772 1987 1941139 SGTC_1438 4092-1045 4 µM 0.200600236628337 0.421661042827331 no 1391 0.420505586514902 1971 1351342 SGTC_640 3381-0960 37.1 µM 0.200548986213956 0.421681809322933 no 1392 0.420525625308661 2031 1745025 SGTC_2473 5854593 8.94 µM 0.200180025006887 0.421831317588428 no 1393 0.420669894364916 1916 2872951 SGTC_2031 5180455 200 µM 0.19914104964312 0.422252385474235 no 1394 0.421076205633749 1979 29949 SGTC_2681 menadione 3.18 µM 0.197122743212282 0.423070602670755 no 1395 0.421865743044308 1974 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1947 st076332 61.6 µM 0.196964685517793 0.423134692989426 no 1396 0.421927586635473 2054 24208416 SGTC_2208 7283366 200 µM 0.196616051782286 0.423276066578525 no 1397 0.422064004149619 2053 898663 SGTC_2701 st077767 14.721 µM 0.196262415949385 0.423419478648114 no 1398 0.422202388496816 1937 5721188 SGTC_1305 1181-0477 144 µM 0.195773594942632 0.423617729876866 no 1399 0.422393689153867 2072 6252086 SGTC_2917 7979103 53.79 µM 0.195259271455863 0.423826345026761 no 1400 0.422594990000317 2027 2980565 SGTC_1084 voriconazole 435 nM 0.194647668770939 0.424074445452522 no 1401 0.422834391220055 2095 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_554 4483-2211 187 µM 0.192410888878371 0.424982064670844 no 1402 0.423710181834607 1970 747107 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.191675463207323 0.425280565821045 no 1403 0.423998213559577 1957 229346 A bile salt which induces apoptosis. SGTC_1433 4060-0023 7.6 µM 0.191556024135203 0.425329048868159 no 1404 0.424044996076084 2030 3840627 SGTC_58 0957-0393 9 µM 0.190072103730822 0.425931499989414 no 1405 0.424626314786461 1947 6997992 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.189796692750179 0.426043332098288 no 1406 0.42473422379765 1968 65057 A dermal irritant. YDR527W RBA50 SGTC_57 miconazole 162.5 nM 0.189645317228623 0.426104801476009 no 1407 0.424793536772565 1932 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3117 9124945 49.47 µM 0.189439226045774 0.426188492243758 no 1408 0.424874291542823 1872 17592065 SGTC_526 4469-0568 170 µM 0.189201359973819 0.426285090485119 no 1409 0.4249675009051 1877 2901964 SGTC_1415 3966-0071 78.1 µM 0.188795826105718 0.426449789397811 no 1410 0.425126421649968 2036 2893185 SGTC_2375 9072683 200 µM 0.188711821213081 0.426483907794114 no 1411 0.425159343036935 2100 16798029 SGTC_1028 k015-0029 4.8 µM 0.186886598395337 0.427225353307108 no 1412 0.425874773502845 1994 4588309 SGTC_2345 9052315 157.45 µM 0.185415366039484 0.427823187442434 no 1413 0.426451628512317 1951 6469265 SGTC_2450 5739737 12.93 µM 0.184220543639025 0.428308824626593 no 1414 0.426920221895503 1976 2262825 SGTC_1192 1488-0095 21.4 µM 0.183986168446328 0.428404099504288 no 1415 0.427012152837124 1985 915875 SGTC_1754 st042065 16.137 µM 0.183632386577138 0.428547921791947 no 1416 0.42715092716468 2004 1126236 YIL048W NEO1 SGTC_2414 st077232 92.9 µM 0.183393698645235 0.428644960516823 no 1417 0.42724455988707 1840 729801 SGTC_2311 7694451 200 µM 0.182824983319824 0.428876189454615 no 1418 0.427467672568222 2005 2163142 SGTC_2964 9083345 53.42 µM 0.181301333531565 0.429495796857832 no 1419 0.428065529683988 1948 17741579 SGTC_2188 6126565 140.678 µM 0.179668171364023 0.430160131436838 no 1420 0.428706541173365 2072 874518 SGTC_2070 5230947 200 µM 0.178121419941248 0.430789498393597 no 1421 0.429313810170094 2102 2835538 SGTC_3262 9137218 49.47 µM 0.178034101315868 0.430825033250177 no 1422 0.429348097277677 2073 17650664 SGTC_2622 2-methoxyxanthone 59.94 µM 0.177437464773193 0.431067853167287 no 1423 0.429582390769941 2073 71034 A hepatoprotective. SGTC_807 1315-0151 48 µM 0.175911235955936 0.431689118133016 no 1424 0.430181838994347 2120 4011080 SGTC_2877 9040724 71.43 µM 0.175662085237427 0.431790553227919 no 1425 0.430279711825806 2137 6463895 SGTC_3352 9151559 45.5865 µM 0.174397417429896 0.432305498337173 no 1426 0.430776571906759 1981 17159339 SGTC_3043 9092303 49.47 µM 0.173938109252291 0.432492547112297 no 1427 0.43095705112722 1943 25236084 SGTC_1495 4469-0029 237 µM 0.173506097066387 0.432668493669912 no 1428 0.431126817900063 2028 793680 SGTC_1560 lithocholic acid 53.1 µM 0.173226807034256 0.432782247846255 no 1429 0.431236576596109 2112 9903 A bile acid which acts as a detergent. SGTC_2618 avocadyne 43.43 µM 0.172726244508029 0.432986139724789 no 1430 0.431433306852964 2020 3015189 SGTC_2290 7904846 200 µM 0.172634219585214 0.433023625765058 no 1431 0.431469476188518 1950 2962154 SGTC_2244 6635614 200 µM 0.172401713995458 0.433118338812822 no 1432 0.431560862390757 1967 836499 SGTC_1750 st081859 2.357 µM 0.171095037781584 0.433650695335292 no 1433 0.432074518809576 2001 5291695 SGTC_750 4073-0104 132 µM 0.170744641506146 0.433793471748253 no 1434 0.432212279685031 2090 22330957 SGTC_2181 6316240 54.2555 µM 0.17058839971832 0.433857138572891 no 1435 0.43227370995221 1962 12779990 SGTC_2058 5236698 133 µM 0.170046998001434 0.434077767133669 no 1436 0.432486587890981 1992 766665 SGTC_1791 st048313 56.1 µM 0.169289586729761 0.434386456973448 no 1437 0.43278443317671 2118 1204976 SGTC_2442 5158906 48.48 µM 0.167831153990836 0.434980967011046 no 1438 0.433358056387221 2082 1893835 SGTC_688 0527-0193 473 µM 0.165921742567709 0.435759534352553 no 1439 0.434109268282451 2026 4007154 SGTC_951 1171-0579 82.7 µM 0.165256709436861 0.436030761923814 no 1440 0.434370965561751 2067 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3292 9120825 59.784 µM 0.164616656468306 0.436291829982512 no 1441 0.434622860057403 2146 24824900 SGTC_2519 cryptotanshinone 88.04 µM 0.162756667629851 0.437050648814358 no 1442 0.435355013732585 2092 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.161891035269463 0.437403879630249 no 1443 0.435695831256079 2024 689007 SGTC_1741 st038134 10.228 µM 0.161852469875436 0.437419617827025 no 1444 0.435711016369704 2073 1272587 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.160622068452286 0.43792178562475 no 1445 0.436195536235071 2050 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_580 1123-0028 41 µM 0.16048180904714 0.437979036523087 no 1446 0.436250775090342 2109 1677248 YPR107C YTH1 SGTC_1695 st026914 34.495 µM 0.160378982531711 0.438021008938852 no 1447 0.436291272408855 1994 3289191 SGTC_2731 amoxapine 43.43 µM 0.160213668072756 0.438088489563354 no 1448 0.43635638145399 2161 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1786 berberine 21.6 µM 0.160017282487125 0.438168655622634 no 1449 0.436433730093091 2114 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1604 st002052 72.4 µM 0.158526717522038 0.438777197832655 no 1450 0.437020884652938 2036 6254834 YHR062C RPP1 SGTC_2109 5483026 200 µM 0.158502932110568 0.438786909708266 no 1451 0.437030255190088 2016 759335 SGTC_2356 9061756 188.97 µM 0.158328808195567 0.43885800776327 no 1452 0.437098854390066 2133 20104043 SGTC_1662 st014054 52 µM 0.158320625861394 0.43886134881208 no 1453 0.437102078012059 2132 2838777 SGTC_576 1073-0113 22.7 µM 0.15715148694637 0.439338781727226 no 1454 0.437562730467665 2152 5439563 SGTC_2649 anisomycin 9.56 µM 0.155256591986219 0.440112773595942 no 1455 0.438309517581127 2046 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2460 5552655 174.22 µM 0.154569460743669 0.440393497047751 no 1456 0.438580373695307 1990 5401989 SGTC_45 0kpi-0036 14.9 µM 0.154468266841759 0.440434841759343 no 1457 0.438620265141667 2041 2795021 SGTC_2298 7976326 193.81 µM 0.154016346094039 0.44061949057771 no 1458 0.438798423523722 2072 2235818 SGTC_2825 7998094 58.44 µM 0.154010275745842 0.440621970929376 no 1459 0.438800816690221 2046 2987815 SGTC_1091 telmisartan 47.6 µM 0.153602323584206 0.440788666013687 no 1460 0.438961652364604 2114 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1730 st033808 45.1 µM 0.153171356863607 0.440964776572291 no 1461 0.43913157250607 1964 1045166 SGTC_2241 6772625 37.8075 µM 0.152269212785446 0.441333467154056 no 1462 0.43948730318695 2185 2285411 SGTC_1486 3970-0793 4.53 µM 0.152091280382117 0.441406191043353 no 1463 0.439557470724314 2155 2844330 SGTC_859 0439-0102 54.6 µM 0.151886145560008 0.441490035458523 no 1464 0.439638367875744 2158 610143 SGTC_3329 9141233 27.5565 µM 0.151541213320036 0.441631024949533 no 1465 0.439774401342364 2111 4909101 YNL103W MET4 SGTC_2499 avocadenofuran 51.48 µM 0.150461215552879 0.442072516896885 no 1466 0.440200373926875 2004 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2150 5556613 200 µM 0.149909319535552 0.442298154114476 no 1467 0.440418079441935 2056 743190 SGTC_2741 miltefosine 3.04 µM 0.14889054385341 0.442714719577906 no 1468 0.440820001477497 2073 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_313 3474-0040 5.03 µM 0.148829247858188 0.442739784818178 no 1469 0.44084418560047 2042 1043375 YIL048W NEO1 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.147657894940952 0.443218819940519 no 1470 0.441306381132901 2128 3256 An antibiotic and ribosome inhibitor. SGTC_931 2812-0076 566 µM 0.146731392509015 0.443597780119594 no 1471 0.441672019570903 1991 3450959 SGTC_1774 st048371 48.465 µM 0.14645768197861 0.443709743723831 no 1472 0.441780047259928 2028 4242727 SGTC_1062 mesoridazine 14.2 µM 0.146224001913637 0.443805336084214 no 1473 0.441872279208071 2134 4078 A neuroleptic. SGTC_193 1273-0060 1.558 µM 0.145919207636573 0.443930024308843 no 1474 0.441992584192295 2141 2847393 YHR072W ERG7 SGTC_134 0269-0018 6.916 µM 0.143320792142124 0.444993233659819 no 1475 0.443018417795221 2016 4378915 SGTC_824 1304-0008 100 µM 0.142486368333881 0.445334744218778 no 1476 0.443347923002832 2053 768245 SGTC_2269 7935389 174.42 µM 0.142469757520564 0.445341543057027 no 1477 0.443354482837211 2000 97605 SGTC_1317 1273-0028 910 nM 0.142366935264103 0.445383628764565 no 1478 0.443395089079502 2055 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_227 fluconazole 33.516 µM 0.140140702200632 0.44629498818025 no 1479 0.444274411092436 2019 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2007 4011539 71.82 µM 0.139650700624573 0.446495619802053 no 1480 0.444467989891697 2074 45595301 SGTC_2140 5586273 200 µM 0.138905801408017 0.446800645732326 no 1481 0.444762293276967 2168 854421 SGTC_3202 9113761 49.47 µM 0.138319785998823 0.447040633070708 no 1482 0.44499384442345 2145 4798415 SGTC_1437 4092-1038 11.6 µM 0.137990932782213 0.447175314836007 no 1483 0.445123791792082 2097 3977136 SGTC_748 act1.228 77.9 µM 0.13777853063678 0.447262307328767 no 1484 0.445207726293995 2055 4421505 YNR035C ARC35 SGTC_1026 k007-1105 30.6 µM 0.135606945516883 0.448151857519828 no 1485 0.446066007225184 2085 7066794 SGTC_1961 st076550 68.7 µM 0.132510566875618 0.449420682439742 no 1486 0.44729023278479 2099 1579337 SGTC_853 0419-0306 21 µM 0.132216088044578 0.449541380251944 no 1487 0.447406688206965 2014 762713 SGTC_2601 securinine 100 µM 0.132164012373493 0.449562724953349 no 1488 0.447427282669609 2064 442872 A GABA receptor antagonist. SGTC_131 0141-0277 33.849 µM 0.132008529796678 0.44962645479712 no 1489 0.447488772497036 2152 1547771 SGTC_23 0213-0011 39.996 µM 0.131843749828634 0.449693996912339 no 1490 0.44755394060903 2174 627608 SGTC_671 0560-0003 407 µM 0.130916814062788 0.45007396827083 no 1491 0.447920556731581 2126 3238678 SGTC_1988 st071872 53.4 µM 0.130403050952817 0.450284590808234 no 1492 0.44812377644598 2192 16414116 SGTC_3180 9109287 49.47 µM 0.129813618876268 0.450526251871751 no 1493 0.448356943893505 2099 18891271 SGTC_209 4077-0173 175.592 µM 0.129697883284896 0.450573704426099 no 1494 0.448402728658484 2105 15993494 SGTC_2137 5261020 140 µM 0.128721665362513 0.45097398993508 no 1495 0.448788945774276 2104 763655 SGTC_1802 st050112 57.9 µM 0.128311278565478 0.451142278633863 no 1496 0.448951319940562 2173 4662563 SGTC_1142 3253-1408 9.78 µM 0.127861654938509 0.451326667392773 no 1497 0.449129228416034 2203 256655 SGTC_2249 haloperidol 116.36 µM 0.127749416420592 0.451372697576676 no 1498 0.44917364089865 2075 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1005 4092-0690 4.4 µM 0.127327701128203 0.451545653244116 no 1499 0.449340518203565 2049 1529343 SGTC_537 1334-0398 209 µM 0.124116061713256 0.452863123854167 no 1500 0.450611690542266 2214 5846986 SGTC_936 3005-4620 401 µM 0.123829793408601 0.452980581524206 no 1501 0.450725020814544 2195 777207 SGTC_331 k048-0133 24.5 µM 0.122803564131393 0.453401683531896 no 1502 0.451131325928588 2143 6813582 SGTC_1990 st072050 59.8 µM 0.122541464939087 0.453509241500503 no 1503 0.451235104573834 2053 17233948 SGTC_1631 benzylvanillin 81.9 µM 0.122386182705054 0.45357296647153 no 1504 0.451296590425714 2085 75506 SGTC_1655 st012546 55.1 µM 0.122231635280518 0.453636391077203 no 1505 0.451357786481247 2124 720985 YLR208W SEC13 SGTC_3144 9087057 49.47 µM 0.122053277039823 0.453709588856215 no 1506 0.451428412328904 2235 17249618 SGTC_743 1275-0778 158 µM 0.121711607690262 0.453849813498047 no 1507 0.451563709990561 2173 2849257 YMR203W TOM40 SGTC_1588 farnesol 29.9 µM 0.121473179515867 0.453947670300939 no 1508 0.451658128508523 2093 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2827 7993847 71.43 µM 0.121083714556205 0.454107522335955 no 1509 0.451812364081553 2110 2985692 SGTC_2892 9047358 58.44 µM 0.120479016999017 0.45435572918111 no 1510 0.452051850285153 2083 6466771 SGTC_2135 5326629 150.42 µM 0.120128741107856 0.454499513138506 no 1511 0.452190582568173 2071 5020077 SGTC_2044 5102272 200 µM 0.11965772771562 0.454692867755237 no 1512 0.452377144039751 2106 592666 SGTC_1683 st010134 710 nM 0.119306775111585 0.454836943478059 no 1513 0.4525161580388 2117 3818134 SGTC_2307 7538926 6.34 µM 0.119029194743783 0.454950902083338 no 1514 0.452626113068828 2082 96582 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.118668543384425 0.455098970417704 no 1515 0.452768979573823 2184 97141 SGTC_2382 9035899 200 µM 0.117891677610727 0.455417940113099 no 1516 0.45307674378318 2097 6462679 SGTC_3141 9094609 49.47 µM 0.117404115430257 0.455618140687605 no 1517 0.453269911493166 1989 25236309 YDL196W YDL196W SGTC_2806 7952793 58.44 µM 0.117351958937608 0.455639557618607 no 1518 0.4532905760776 2129 2972490 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.116495587481158 0.455991226348529 no 1519 0.453629891484532 2219 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_220 paclitaxel 373.376 µM 0.115792180420696 0.456280106090474 no 1520 0.453908623974119 2189 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1854 st056233 32.9 µM 0.115389535270195 0.456445477404821 no 1521 0.454068186601152 2218 5393174 SGTC_1452 4194-0072 190 µM 0.11347047995765 0.457233760194604 no 1522 0.454828782741696 2198 1343545 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.113354494653873 0.457281408444981 no 1523 0.454874757557388 2170 23847180 SGTC_1494 4358-1428 177 µM 0.11305437544447 0.45740470411404 no 1524 0.454993723065279 2231 1564571 SGTC_838 0109-0203 71.4 µM 0.112792805844836 0.457512166087213 no 1525 0.455097411024703 2194 759422 SGTC_886 0866-0150 153 µM 0.112406132985763 0.457671030558828 no 1526 0.455250696364506 2205 271463 SGTC_2525 harmine 47.85 µM 0.111873830995994 0.457889737790116 no 1527 0.455461723081354 2155 5280953 A monoamine oxidase inhibitor SGTC_2695 st077686 51.995 µM 0.110719537744467 0.458364046655012 no 1528 0.455919376178916 2105 2876092 SGTC_1357 1503-1303 39.5 µM 0.109450490599744 0.458885577265803 no 1529 0.456422594273334 2179 292895 SGTC_609 0986-0026 86.3 µM 0.105877040180395 0.460354508220407 no 1530 0.457839955470218 2162 2848610 SGTC_2857 9024691 58.44 µM 0.105750443835171 0.460406557965826 no 1531 0.457890178156006 2131 16478292 SGTC_2707 st078556 66.6 µM 0.104913471247728 0.460750694012698 no 1532 0.458222234726109 2239 17250899 SGTC_521 r062-0005 13.8 µM 0.104559046030678 0.460896431069318 no 1533 0.458362856522304 2085 2832033 SGTC_2511 berberine 10.47 µM 0.101360083849732 0.46221205620017 no 1534 0.459632310853505 2157 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2083 5306046 65.942 µM 0.100872503691475 0.462412618132006 no 1535 0.459825835312716 2147 539837 SGTC_84 0443-0269 128.823 µM 0.099690007917626 0.462899067258927 no 1536 0.460295216775076 2224 6150058 SGTC_338 4055-0136 114 µM 0.0995716653721125 0.462947753482787 no 1537 0.460342194880991 2215 2900563 SGTC_730 1436-0052 41.2 µM 0.0995615240163555 0.462951925670999 no 1538 0.460346220692093 2253 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.0981941341740868 0.463514511631841 no 1539 0.460889070103308 2148 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2195 6536160 144.242 µM 0.0978376169728156 0.463661205740312 no 1540 0.461030618317406 2186 3834386 SGTC_3050 9093513 49.47 µM 0.0970249330202688 0.46399561462811 no 1541 0.461353297086225 2208 25236664 SGTC_1206 3978-0017 132 µM 0.0967638945430374 0.464103033979003 no 1542 0.461456948659664 2148 3873677 SGTC_2557 derrustone 83.84 µM 0.0962500745372222 0.464314482519914 no 1543 0.461660980829717 2057 629853 An antioxidant. SGTC_2746 daunorubicin 9.88 µM 0.0957852834196229 0.464505763249676 no 1544 0.46184555287115 2235 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3123 9126162 49.47 µM 0.0952590851363077 0.464722325461229 no 1545 0.462054520074462 2234 25239884 SGTC_583 1488-1091 88.9 µM 0.0952320221069343 0.464733463807075 no 1546 0.46206526780023 2256 4303273 SGTC_1105 epirubicin 18.1 µM 0.0947389670505724 0.46493639557641 no 1547 0.462261082965247 2116 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2056 5235370 200 µM 0.0942395742573083 0.465141945130112 no 1548 0.462459424465211 2135 5511916 SGTC_3286 9117135 37.221 µM 0.0934380943664674 0.465471852838671 no 1549 0.462777763976616 2136 3438150 SGTC_517 1365-0151 113 µM 0.09332431626877 0.465518688470979 no 1550 0.462822957395737 2143 768657 SGTC_814 3342-0569 96 µM 0.0920142273081727 0.466058007926061 no 1551 0.46334336789493 2240 4346283 SGTC_835 0312-0010 67.2 µM 0.0906438461559349 0.466622214335966 no 1552 0.46388779555953 2220 1626196 SGTC_32 0928-0142 34.1 µM 0.0897498931421804 0.466990304380881 no 1553 0.46424298344794 2252 2244242 SGTC_806 3966-4455 5.86 µM 0.089085137554341 0.4672640394517 no 1554 0.464507124470931 2083 714982 SGTC_2513 baicalein 25.65 µM 0.0881209392473026 0.467661107433371 no 1555 0.464890277002752 2151 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_164 4100-3994 89.624 µM 0.0863955493581887 0.468371722941139 no 1556 0.4655759924006 2253 4615967 SGTC_1394 3474-0001 65.7 µM 0.0861504631142134 0.468472671881655 no 1557 0.465673404469469 2187 5017666 YIL048W NEO1 SGTC_2222 6885208 172.143 µM 0.0860155386478663 0.468528246988005 no 1558 0.465727032475802 2238 609514 SGTC_2907 7721985 69.9 µM 0.084778302042633 0.469037890625758 no 1559 0.466218821943638 2180 3267881 SGTC_8 0354-0001 70 µM 0.0847350528205128 0.469055706807669 no 1560 0.466236014024574 2193 4993152 SGTC_3008 9078912 71.4286 µM 0.0847146337491376 0.469064118307428 no 1561 0.466244130870555 2204 16648731 SGTC_1620 st003704 16.5 µM 0.084537576306014 0.469137056514405 no 1562 0.466314514091367 2243 2834414 SGTC_1314 1222-0010 41.1 µM 0.0842759568448955 0.469244831650164 no 1563 0.466418514020977 2169 3526027 SGTC_2468 5987765 72.9 µM 0.0830197287347592 0.469762370867273 no 1564 0.466917926251303 2175 26772094 SGTC_1878 temozolomide 1 mM 0.082722818130492 0.469884699207227 no 1565 0.467035970404833 2272 5394 DNA alkylating agent. SGTC_2028 5153890 36.43 µM 0.0808991939799221 0.470636101459471 no 1566 0.467761060488449 2228 2830968 YPR165W RHO1 SGTC_1974 st069448 26.9 µM 0.0794217080292676 0.471244958455791 no 1567 0.46834860133394 2274 6323587 YNR016C ACC1 SGTC_1106 tegaserod maleate 11.7 µM 0.0790319321310166 0.471405592419122 no 1568 0.46850361216156 2171 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2776 terbinafine 19.92 µM 0.078832536802302 0.471487768776755 no 1569 0.468582911972687 2264 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3086 9117350 49.47 µM 0.0786198383840812 0.471575429045392 no 1570 0.468667503815738 2273 2679265 SGTC_2575 plumbagin 510 nM 0.0773905377792014 0.472082092575907 no 1571 0.469156433983103 2223 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_196 k015-0023 18.111 µM 0.0769798398907934 0.472251374254169 no 1572 0.469319791403377 2184 5211998 SGTC_97 0535-0701 19.132 µM 0.0757103283993781 0.472774673748857 no 1573 0.469824779353134 2260 2832013 YGL099W LSG1 SGTC_2724 maprotiline 69.64 µM 0.0748148903655333 0.473143806460094 no 1574 0.470180997111704 2258 4011 A tricyclic antidepressant. SGTC_858 0438-0351 2.77 µM 0.0746713497699116 0.473202981361361 no 1575 0.470238101792599 2169 2799119 SGTC_581 0958-0271 211 µM 0.0743305646116263 0.473343473099293 no 1576 0.470373678625222 2248 4591145 SGTC_2024 5144227 134 µM 0.0733249076267948 0.473758083474934 no 1577 0.470773785813033 2244 3475211 SGTC_893 0958-0369 48.9 µM 0.0726734430612517 0.474026683264727 no 1578 0.471032991010299 2287 6819948 SGTC_3134 9127454 49.47 µM 0.071681281399006 0.474435775608318 no 1579 0.471427776557964 2290 24262820 SGTC_2324 6149169 200 µM 0.0714254916686199 0.474541248312925 no 1580 0.471529560999807 2252 2888231 SGTC_2890 9046729 58.44 µM 0.0706490978498859 0.474861398551683 no 1581 0.471838516786956 2184 903329 SGTC_2636 apigenin dimethyl ether 100 µM 0.0705264433757904 0.474911977285225 no 1582 0.471887327089002 2224 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_87 0100-0052 35.5 µM 0.0691909454461385 0.475462719382959 no 1583 0.472418815161626 2272 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2148 5546263 113.568 µM 0.0685369387091958 0.475732440481679 no 1584 0.472679108177438 2214 792097 SGTC_1459 k035-0031 35.7 µM 0.0684794715460962 0.475756141239298 no 1585 0.472701980521268 2263 3877128 YMR208W ERG12 SGTC_305 1682-2595 20.8 µM 0.0684728188573251 0.475758884964132 no 1586 0.472704628345015 2206 226033 SGTC_462 ag-879 158 µM 0.0684556129939799 0.47576598107093 no 1587 0.472711476422887 2282 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1169 aniline yellow 25.8 µM 0.0673280079616807 0.476231048827136 no 1588 0.473160290171169 2257 6051 A DNA damaging agent. SGTC_1231 0242-0792 125 µM 0.0649400797725138 0.477216028522776 no 1589 0.474110854441359 2244 3707635 SGTC_3057 9095946 49.47 µM 0.0640389023083549 0.477587785379099 no 1590 0.474469625400347 2304 24540043 SGTC_1548 st061468 90.8 µM 0.0628484084714967 0.4780789218783 no 1591 0.474943608823225 2294 390799 SGTC_304 1310-0298 97 µM 0.0612671271619131 0.478731328533889 no 1592 0.47557323516337 2269 1550234 SGTC_3151 9099821 49.47 µM 0.0612341259305059 0.478744944828798 no 1593 0.475586376076766 2236 17174189 SGTC_362 0310-0100 9.03 µM 0.0611621181890997 0.478774655280265 no 1594 0.47561504926546 2242 790235 SGTC_1050 3232-1156 69.3 µM 0.0607276353325467 0.478953925749954 no 1595 0.475788061239864 2222 700529 SGTC_2094 5332512 191.667 µM 0.0600787685556882 0.479221660344376 no 1596 0.476046449825335 2287 755774 SGTC_3100 9120536 49.47 µM 0.0600434040108737 0.479236252688949 no 1597 0.476060532813545 2323 16421196 SGTC_1180 1193-0155 285 µM 0.0591787942774965 0.479593022095014 no 1598 0.476404849875299 2245 2921347 SGTC_449 xestospongin c 11.1929 µM 0.0591181432055453 0.479618049549076 no 1599 0.476429003863409 2267 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2173 5763948 167 µM 0.0585362338645271 0.479858176485957 no 1600 0.476660750756447 2308 2867177 SGTC_2248 tofa 1.1 µM 0.0585206832181538 0.479864593615565 no 1601 0.476666943950042 2221 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2510 benzyl isothiocyanate 8.31 µM 0.0575305082014691 0.480273209904048 no 1602 0.477061302157888 2297 2346 DNA damaging agent; causes G2/M arrest. SGTC_1442 4112-3290 3 µM 0.0574850703521543 0.480291961277134 no 1603 0.47707939928743 2308 704353 SGTC_2673 kobusone 100 µM 0.0571436879424011 0.480432844973616 no 1604 0.47721536765647 2309 6710676 An epoxy ketone and protein crosslinker. SGTC_2447 5741742 33.78 µM 0.0555588740324627 0.481086907011151 no 1605 0.477846613819045 2258 1776504 SGTC_3317 9138495 8.753 µM 0.054941373328055 0.481341767071352 no 1606 0.478092585244406 2303 17020139 SGTC_629 3448-6466 76.7 µM 0.0541056473142547 0.481686707033505 no 1607 0.478425496467083 2302 573744 SGTC_2920 7982904 15.77 µM 0.0539943223275819 0.481732656669619 no 1608 0.478469843885482 2268 6456808 SGTC_2733 amorolfine 100 µM 0.0531093223396262 0.482097950967785 no 1609 0.478822401892213 2314 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_899 1083-0020 478 µM 0.0525847522172975 0.482314480655467 no 1610 0.479031383064521 2299 767123 SGTC_85 0868-0259 160.055 µM 0.052101572616486 0.482513929967648 no 1611 0.479223879951611 2257 83173 SGTC_793 0488-0545 106 µM 0.0520220287846012 0.48254676489255 no 1612 0.47925557037282 2214 292548 SGTC_484 loperamide 105 µM 0.0516278927327151 0.482709462187088 no 1613 0.479412596892479 2310 3955 An opioid-receptor agonist. SGTC_850 0388-0143 75.9 µM 0.0505468896340235 0.483155709293263 no 1614 0.479843292305352 2268 67273 SGTC_1171 0368-0077 21.4 µM 0.0502007385198517 0.483298607850905 no 1615 0.479981211521996 2285 3239779 SGTC_1060 3448-7350 82 µM 0.0487704861033642 0.48388906907475 no 1616 0.480551101426147 2309 570178 SGTC_2495 cafestol 54.53 µM 0.0486674619312492 0.483931602652274 no 1617 0.480592153376178 2254 16667697 An anti-infammatory. SGTC_1285 0929-0069 65.5 µM 0.0484800602231209 0.48400897200337 no 1618 0.4806668276952 2281 1206237 SGTC_2952 9073731 13.78 µM 0.0483920291555149 0.484045316098782 no 1619 0.480701905838356 2285 16457353 SGTC_1123 mangostin 811.285 nM 0.0477865491589642 0.484295295317479 no 1620 0.480943178263023 2202 5281650 An antioxidant. SGTC_3045 9092950 49.47 µM 0.0444755408437737 0.485662388881584 no 1621 0.482262674129449 2326 44120432 SGTC_2998 9066762 71.4286 µM 0.0430909444831067 0.486234130513029 no 1622 0.482814518925796 2296 4945196 SGTC_690 glyoxal 20.3 µM 0.0421596776711095 0.486618694679107 no 1623 0.483185703259231 2300 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1568 digitonin 820 nM 0.0420016608184732 0.486683948565012 no 1624 0.483248687072679 2332 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2911 7942208 15.64 µM 0.0415689053500073 0.486862659019575 no 1625 0.483421180871091 2278 1243384 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.0401578313046582 0.487445393500819 no 1626 0.483983648117752 2343 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2655 perillic acid 100 µM 0.0397890549889545 0.487597692369463 no 1627 0.484130651088065 2285 5702197 An apoptosis inducer. SGTC_3240 9133527 49.47 µM 0.0397630672039606 0.487608424987959 no 1628 0.484141010516023 2319 17617455 SGTC_397 arbidol 50 µM 0.039435786864527 0.487743588293381 no 1629 0.484271474149309 2325 131410 A RNA synthesis inhibitor. SGTC_3335 9143315 29.6265 µM 0.0390459879902372 0.487904572925508 no 1630 0.484426861717506 2255 4899691 SGTC_3192 9110362 49.47 µM 0.0386972821588208 0.48804858804459 no 1631 0.484565870155541 2347 16649480 SGTC_974 1326-0144 138 µM 0.0367192092952481 0.488865558869361 no 1632 0.485354446084013 2298 5411856 SGTC_2285 7945142 200 µM 0.0363067425744344 0.489035919199965 no 1633 0.485518886844498 2317 2970608 SGTC_1203 3992-3522 103 µM 0.0360401580190388 0.489146027168609 no 1634 0.485625169135708 2346 5322312 SGTC_2121 5257820 149.641 µM 0.0358959345166819 0.489205596444553 no 1635 0.485682668782887 2349 791256 SGTC_2589 lobaric acid 100 µM 0.035607205071123 0.489324852376455 no 1636 0.485797781575273 2314 73157 A novel microtubule depolymerizer. SGTC_14 0354-0009 295 µM 0.0354000103941907 0.489410432024339 no 1637 0.48588038821253 2345 1713507 SGTC_2483 5729050 27.16 µM 0.0352525104547898 0.489471355667088 no 1638 0.485939195469109 2332 2865180 SGTC_979 1426-2828 121 µM 0.0346640331988749 0.489714423812289 no 1639 0.486173820514976 2303 747872 SGTC_1230 0170-0365 3.77 µM 0.0342913750737304 0.489868350721506 no 1640 0.48632240126026 2337 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_529 4076-0302 30.3 µM 0.0342647111472976 0.489879364348111 no 1641 0.486333032380341 2269 5816522 SGTC_3274 9138298 49.47 µM 0.0328019016742146 0.490483594430182 no 1642 0.486916280856755 2349 17015756 SGTC_2635 hydroquinidine 100 µM 0.0319031122885334 0.490854860523433 no 1643 0.487274658328628 2336 442912 An experimental heart treatment. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.0307669996674627 0.491324169857474 no 1644 0.487727679202148 2357 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2787 5284540 71.43 µM 0.0304342766303072 0.491461614544069 no 1645 0.487860354355733 2311 736958 SGTC_1224 0823-0416 294 µM 0.0303572841690807 0.49149341953434 no 1646 0.487891055717957 2341 3598164 SGTC_1159 4092-0538 61.2 µM 0.0299562983827708 0.49165906453116 no 1647 0.488050953176415 2360 717301 SGTC_1366 1683-0113 21.9 µM 0.029304894684119 0.491928158827649 no 1648 0.488310711593453 2347 708623 SGTC_3089 9117425 49.47 µM 0.0291645900882302 0.491986119018155 no 1649 0.488366661114539 2230 9401657 SGTC_3245 9134821 49.47 µM 0.0277575805879398 0.492567367425059 no 1650 0.488927749350742 2356 17014901 SGTC_128 0906-2981 13.371 µM 0.0272964537600719 0.492757866600743 no 1651 0.489111642652828 2362 6740226 SGTC_2658 polymyxin b sulfate 77.05 µM 0.0267365237793367 0.492989185221389 no 1652 0.489334940886771 2344 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_495 decylubiquinone 155 µM 0.0262704849922399 0.493181717254967 no 1653 0.489520798173704 2279 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3237 9133362 49.47 µM 0.0262328099524631 0.493197281806338 no 1654 0.489535823161866 2353 43845137 SGTC_2132 5317594 122.667 µM 0.0246063354633072 0.493869230819671 no 1655 0.490184482930981 2345 794577 SGTC_851 0394-0702 453 µM 0.0241761264196758 0.494046967023433 no 1656 0.490356060460488 2370 762646 SGTC_2469 5655019 90.81 µM 0.0241519013204132 0.494056975396118 no 1657 0.490365722055718 2358 2788239 SGTC_1731 st035964 63 µM 0.0236969736252761 0.494244925196899 no 1658 0.490547160013226 2193 6739575 SGTC_79 0052-0007 94.094 µM 0.0207184552662822 0.495475506299198 no 1659 0.491735123502989 2371 2801472 SGTC_1540 guanosine 70.6 µM 0.0191890542127664 0.496107399017388 no 1660 0.492345144734709 2362 6802 Guanosine is a purine nucleoside SGTC_585 0kpi-0023 191 µM 0.018510700963416 0.49638767305242 no 1661 0.492615720447271 2369 64601 SGTC_2224 6650123 117.647 µM 0.0184137910856342 0.49642771328726 no 1662 0.492654375306488 2374 2908370 SGTC_337 1315-0038 354 µM 0.017894603632011 0.496642226466606 no 1663 0.492861467001944 2362 1626437 SGTC_2036 5160441 105 µM 0.0175539399213484 0.49678297935082 no 1664 0.492997350813256 2358 134534 YIL048W NEO1 SGTC_2445 5742597 35.57 µM 0.0169885232328445 0.497016594864968 no 1665 0.493222885792804 2353 1774255 SGTC_2035 5154463 94.595 µM 0.0168536451430375 0.497072323148359 no 1666 0.49327668666272 2373 2769623 SGTC_3064 1327-0027 10 µM 0.0157988373325069 0.497508145474582 no 1667 0.493697437997974 2348 16000455 YPR107C YTH1 SGTC_830 4076-0286 57.8 µM 0.0146831483196514 0.497969125738814 no 1668 0.494142481801763 2360 6866659 SGTC_2063 5246145 200 µM 0.0139882758694142 0.49825623447124 no 1669 0.494419667312046 2375 711240 SGTC_195 4234-0266 16.654 µM 0.0137906151951488 0.498337904459413 no 1670 0.494498514906179 2373 2303354 SGTC_1837 st055472 66.5 µM 0.0125344512977977 0.498856931244013 no 1671 0.494999608353332 2358 676091 SGTC_2965 9082772 38.63 µM 0.0120000212026637 0.499077749829477 no 1672 0.495212799070048 2386 16459634 SGTC_564 3555-0129 330 µM 0.0118024733014332 0.499159373766184 no 1673 0.495291603698996 2390 563260 SGTC_2049 5262831 67.185 µM 0.0112029197658509 0.499407100820221 no 1674 0.49553077512697 2378 763417 SGTC_1101 ebselen 5.29 µM 0.0111935380531926 0.499410977213469 no 1675 0.495534517654148 2395 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_841 0251-0215 91.2 µM 0.0110490321796239 0.499470685038344 no 1676 0.49559216359181 2343 3888614 SGTC_879 0831-1030 162 µM 0.0103825124332157 0.499746081895757 no 1677 0.495858051228372 2390 1549252 SGTC_1121 fusaric acid 630.51 nM 0.00985849789126204 0.499962597640228 no 1678 0.496067092076571 2382 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1926 methyl fluorone black 53.6 µM 0.00967745443917179 0.499962597640228 no 1679 0.496139314518526 2386 72721 Reacts with homocysteine. SGTC_1726 st035556 14.5795 µM 0.00943356750007654 0.499861826839599 no 1680 0.496236606888051 2375 5919439 SGTC_672 1441-0018 53.7 µM 0.00914513086172343 0.499742648714739 no 1681 0.496351671493223 2391 251141 SGTC_2610 ononetin 44.17 µM 0.00794509324154771 0.499246809738309 no 1682 0.496830399730826 2374 259632 SGTC_2873 9040596 71.43 µM 0.00720021777369333 0.498939038015583 no 1683 0.497127553521436 2337 6463863 SGTC_3150 9097574 49.47 µM 0.00669584292909206 0.498730638004053 no 1684 0.49732876511317 2388 17217476 SGTC_2684 capsaicin 100 µM 0.00640711197053655 0.498611338917385 no 1685 0.497443949627805 2385 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_125 0133-0007 11.75 µM 0.00628958390852997 0.498562778207332 no 1686 0.497490835596049 2392 26541 SGTC_2804 7954240 19.48 µM 0.00581344654892527 0.498366046113036 no 1687 0.497680783440223 2389 828705 SGTC_691 1548-0686 185 µM 0.00472439592043916 0.497916069948361 no 1688 0.498115245729243 2399 46495133 SGTC_2549 cedrol 20.94 µM 0.00434513433045625 0.497759366462625 no 1689 0.498266547656211 2396 6708665 A sedative which affects the nervous system. SGTC_3325 9138760 55.175 µM 0.00418373797151313 0.49769268074105 no 1690 0.49833093490217 2393 43844959 SGTC_2329 6138490 200 µM 0.0040660394109984 0.497644050109332 no 1691 0.498377889434814 2383 720019 SGTC_1735 st034310 56.75 µM 0.00395180216131383 0.497596849653746 no 1692 0.498423463137466 2360 871153 SGTC_2962 9082311 13.18 µM 0.00323708335285633 0.497301543497204 no 1693 0.498708592840742 2391 16459453 SGTC_439 amiodarone 34.4 µM 0.00309513762878207 0.497242894804022 no 1694 0.498765220707723 2374 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2686 alizarin 95.37 µM 0.00291996547255565 0.497170517799133 no 1695 0.498835103971041 2394 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1851 st056236 18.9 µM 0.00168542045283043 0.49666043568132 no 1696 0.499327614839447 2403 5393171 SGTC_2471 5466956 24.79 µM 0.00107718688285483 0.496409131234622 no 1697 0.499570264691641 2397 724419 SGTC_559 1550-0661 158 µM 0.000994500374763135 0.496374967678681 no 1698 0.499603251818031 2403 5830875 SGTC_3267 9137951 49.47 µM 0.000881382731445063 0.496328230944239 no 1699 0.499648379208736 2403 16643986 SGTC_1545 lovastatin 49.4 µM 0.000597778479824597 0.496211054604787 no 1700 0.499761520904287 2403 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_271 rotenone 740 µM 0.000462396293223841 0.496155119066276 no 1701 0.499815530574906 2399 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1860 st056228 74.6 µM 6.94109612809515e-05 0.495992750676323 no 1702 0.499972309032844 2405 688679 SGTC_150 3970-0969 77.2 µM -0.000233340581290715 0.495867664320226 no 1703 0.499906910577234 2407 6615640 SGTC_2968 9090663 33.37 µM -0.00036480209467631 0.495813349143317 no 1704 0.499854465023683 2410 25236811 SGTC_1100 amiodarone 5.07 µM -0.000709192731771555 0.495671059668743 no 1705 0.49971707305806 2407 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1873 rapamycin 2 nM -0.000853356200148323 0.495611496817719 no 1706 0.499659560172837 2408 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_612 0302-0167 22.4 µM -0.000962438318321186 0.495566428308586 no 1707 0.499616042721819 2405 235821 SGTC_1475 4092-1048 11.7 µM -0.00169151299079924 0.495265204354252 no 1708 0.499325184271921 2412 2881759 SGTC_3226 9131256 49.47 µM -0.00176076531432108 0.495236592253003 no 1709 0.499297556633217 2409 17178073 SGTC_157 1348-1695 65.819 µM -0.00299061752594811 0.494728474083636 no 1710 0.498806918002836 2415 5380510 SGTC_2866 9034245 58.44 µM -0.00371443836720315 0.494429428665454 no 1711 0.498518156894889 2411 6462273 SGTC_500 h-89 112 µM -0.00381598339661115 0.494387475746164 no 1712 0.498477646576466 2410 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2439 5492030 7.2 µM -0.00395608641502615 0.494329592851254 no 1713 0.49842175398088 2411 5722370 SGTC_1935 st074532 41.6 µM -0.00494069587179227 0.493922809579501 no 1714 0.498028955541163 2433 2829742 SGTC_1471 k673-0312 37 µM -0.00514681407970858 0.493837654328653 no 1715 0.497946727319337 2416 24099884 SGTC_1385 3091-4834 14.1 µM -0.0062047781405442 0.493400573744822 no 1716 0.497524667542319 2414 4072814 SGTC_3027 9089541 49.47 µM -0.00653717102717757 0.493263252659844 no 1717 0.497392064657905 2432 9943819 SGTC_3332 9141069 11.198 µM -0.00789310083623597 0.492703087405465 no 1718 0.496851141049186 2417 17332883 SGTC_683 panaxydol 45 µM -0.00863510276998533 0.492396555654982 no 1719 0.496555135220552 2434 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_264 promethazine 12.5 mM -0.00870473485262745 0.49236778986031 no 1720 0.496527357082745 2421 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3149 9097855 49.47 µM -0.00878427430852333 0.49233493126715 no 1721 0.496495626644015 2431 25236625 YMR079W SEC14 SGTC_2125 5246583 200 µM -0.00958229632358288 0.492005262821408 no 1722 0.496177275353963 2419 835267 SGTC_2268 7933382 153.85 µM -0.00959441557955612 0.492000256313984 no 1723 0.496172440692595 2418 935025 YOR257W CDC31 SGTC_791 1348-1292 225 µM -0.0119358404447292 0.49103303002536 no 1724 0.49523840165436 2474 5437054 SGTC_339 3091-4833 71.4 µM -0.0125267970698691 0.490788918072234 no 1725 0.495002661708753 2443 3240077 SGTC_959 1222-0044 107 µM -0.0142406842396197 0.490080966587327 no 1726 0.494318980971304 2431 6083612 SGTC_3042 9091578 49.47 µM -0.0146294988299239 0.489920364095189 no 1727 0.494163882552887 2420 25236497 SGTC_2167 5876490 200 µM -0.0156392977598575 0.489503267526429 no 1728 0.49376107721607 2469 686534 SGTC_1350 1495-0454 146 µM -0.0162223189582411 0.489262456325772 no 1729 0.493528514925898 2451 1069057 SGTC_2880 9042983 58.44 µM -0.0178197873391905 0.488602657959549 no 1730 0.492891309625928 2461 6464714 SGTC_1454 4239-0054 42.6 µM -0.0186641954524417 0.488253906676848 no 1731 0.492554495583152 2473 1340767 SGTC_3242 9133940 49.47 µM -0.0192897644884342 0.487995544491089 no 1732 0.492304974582968 2482 17248444 SGTC_1393 3470-5649 58.2 µM -0.0197016065382781 0.487825455036604 no 1733 0.492140704598578 2464 4108395 SGTC_2969 9091408 28.7 µM -0.0208472854475459 0.487352305041872 no 1734 0.491683738795164 2475 4286311 SGTC_2347 9049783 174.81 µM -0.0217495061846402 0.486979712497031 no 1735 0.491323886436754 2456 6467988 YPL169C MEX67 SGTC_2354 9060492 162 µM -0.0219003822046963 0.486917405918178 no 1736 0.491263709946898 2449 6471895 SGTC_973 1325-0077 65.9 µM -0.0233872100640397 0.486303414747588 no 1737 0.49067070355372 2477 2835149 SGTC_158 k038-0087 26.446 µM -0.026836247933719 0.484879249027762 no 1738 0.489295170975451 2463 X158 SGTC_1481 3346-2004 36 µM -0.0269763691522727 0.484821394574957 no 1739 0.48923929092786 2447 2770522 SGTC_1942 st076330 65.2 µM -0.0271603812425093 0.48474541856741 no 1740 0.489165907613853 2518 24208414 SGTC_1892 st058411 7.36 µM -0.027428799996723 0.484634593227688 no 1741 0.489058863905189 2453 3934738 SGTC_1216 1165-0504 9.65 µM -0.0277622845300364 0.484496905036909 no 1742 0.488925873472283 2463 6304004 SGTC_334 1502-1024 68.5 µM -0.0283674697660766 0.48424704252844 no 1743 0.488684534560319 2522 3296216 SGTC_294 k038-0071 157 µM -0.0289569458959478 0.484003671776398 no 1744 0.488449464189821 2485 24152826 SGTC_1520 flindersine 88 µM -0.0339330673226771 0.481949479782122 no 1745 0.486465262226974 2520 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2817 7995342 71.43 µM -0.0344926208688908 0.481718519520173 no 1746 0.486242163271116 2473 18879975 SGTC_2904 7225135 42.03 µM -0.0346659533289424 0.481646976383341 no 1747 0.486173054954019 2485 4446116 SGTC_282 k297-0036 65.7 µM -0.0354152129795073 0.481337725582833 no 1748 0.485874327059098 2479 5061378 SGTC_2588 indole-3-carbinol 100 µM -0.036095471677632 0.481056964083306 no 1749 0.485603116527259 2502 3712 Induces cell cycle arrest. SGTC_364 0083-0097 67.7 µM -0.0383897835470454 0.480110108484102 no 1750 0.484688453263661 2524 5207356 SGTC_1441 4106-0040 13 µM -0.0403615117613518 0.479296471645565 no 1751 0.483902457197487 2470 2904180 SGTC_983 1491-0821 12.2 µM -0.0403840821694524 0.479287158423055 no 1752 0.483893460242749 2505 46495113 SGTC_2739 tacrine 100.86 µM -0.0423871092490622 0.478460695425681 no 1753 0.483095052221786 2529 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_279 1273-0055 2.93 µM -0.0425993378359307 0.478373133788873 no 1754 0.483010461671499 2478 2847562 SGTC_669 0108-0021 26.2 µM -0.0428170232434612 0.478283321852089 no 1755 0.482923696923832 2470 17201 SGTC_1205 4161-2785 76 µM -0.0432188832705802 0.478117526650731 no 1756 0.482763526239346 2595 3498106 SGTC_1708 st033234 31.827 µM -0.0433773797871793 0.478052136857563 no 1757 0.482700354520308 2555 674664 SGTC_2342 7990637 118.86 µM -0.0434642166275261 0.47801631144347 no 1758 0.482665744275076 2517 2033102 YER133W GLC7 SGTC_2611 pyromycin 23.93 µM -0.0435748219841225 0.477970680345597 no 1759 0.48262166088752 2508 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3271 9137798 49.47 µM -0.0438171824527918 0.4778706936647 no 1760 0.482525065310667 2486 6498326 SGTC_1855 st056195 39.6 µM -0.0446668344828479 0.47752017771374 no 1761 0.482186434774789 2509 4028379 SGTC_414 piperonyl butoxide 100 µM -0.0448076981475446 0.477462067407416 no 1762 0.482130294511542 2481 5794 A potent inhibitor of cytochrome P450. SGTC_2595 hexamethylquercetagetin 100 µM -0.044891862789537 0.477427347304582 no 1763 0.482096751430318 2527 386331 SGTC_1264 0783-0040 158 µM -0.0451648708750034 0.477314725552616 no 1764 0.481987947321495 2492 2855798 SGTC_1872 amphotericin b 148 nM -0.045423843610435 0.477207895361008 no 1765 0.48188473807342 2499 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_3298 9116858 71.43 µM -0.04705515740702 0.476534991577961 no 1766 0.48123463346253 2549 2506942 SGTC_749 1000-0129 128 µM -0.0475210489466754 0.476342827274524 no 1767 0.481048977325896 2536 708470 SGTC_924 2046-0044 21.3 µM -0.0489108576393364 0.475769611650217 no 1768 0.480495168037395 2487 3623589 SGTC_2458 5808907 16.39 µM -0.0502835408711497 0.475203508501981 no 1769 0.479948219829457 2497 2731747 SGTC_3032 9089427 49.47 µM -0.0505044754331783 0.475112398353798 no 1770 0.479860191539026 2560 17173707 SGTC_3259 9138485 49.47 µM -0.0545654475471579 0.473437950181886 no 1771 0.478242333295965 2508 17646153 SGTC_1487 3970-0795 2.82 µM -0.0560317032902261 0.472833487193083 no 1772 0.477658275625897 2544 3765103 SGTC_1065 prochlorperazine maleate 2.48 µM -0.0578648631604998 0.472077856367667 no 1773 0.476928135670411 2514 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1355 1499-0035 1.68 µM -0.0579792557921638 0.472030706882559 no 1774 0.476882576102613 2515 1548538 SGTC_2698 st077697 67.5 µM -0.0585120989335079 0.47181108882377 no 1775 0.476670362725889 2542 3154499 SGTC_2927 9011802 47.9 µM -0.0588497478984522 0.471671926952597 no 1776 0.476535891999563 2559 43912568 SGTC_2646 retinol 96.75 µM -0.0598107443121417 0.471275871693423 no 1777 0.476153184087511 2569 445354 A vitamin A analog and teratogen. SGTC_18 0111-0177 500 nM -0.0614687616945768 0.470592620326759 no 1778 0.475492945951243 2515 721752 SGTC_372 0155-0182 15.9 µM -0.062453894512462 0.470186698414021 no 1779 0.475100688535928 2521 771486 SGTC_1956 st077085 54 µM -0.0631981188655626 0.469880062847962 no 1780 0.474804371357464 2556 24208685 SGTC_1149 3909-7961 23.3 µM -0.063894445512604 0.469593178280961 no 1781 0.47452713754114 2531 735261 SGTC_1941 st076221 61.8 µM -0.064107084386865 0.469505574818214 no 1782 0.474442480463408 2578 2828568 SGTC_2297 7971671 152.32 µM -0.0641131867320927 0.469503060781466 no 1783 0.474440050977747 2557 909016 SGTC_393 acivicin 6.25 µM -0.066154948341834 0.468661967204231 no 1784 0.473627232086409 2544 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2791 5663188 71.43 µM -0.066897381400834 0.468356160059823 no 1785 0.473331698854927 2591 54690634 SGTC_2879 9041815 71.43 µM -0.0688296335963791 0.467560356047399 no 1786 0.472562614908717 2520 4942971 SGTC_967 1306-0166 352 µM -0.0713218144344158 0.46653413557573 no 1787 0.471570817014923 2544 4437607 SGTC_2760 etidronate 98.04 µM -0.0715216906974852 0.466451840855596 no 1788 0.471491281040943 2569 3305 A chelator and antioxidant. SGTC_3016 9080866 49.47 µM -0.0715650128744856 0.466434004076986 no 1789 0.471474042167529 2535 17066299 SGTC_419 nsc-638432 893 µM -0.0716059600642674 0.466417145199511 no 1790 0.47145774840434 2586 368090 SGTC_1136 pergolide 1.05886 µM -0.0718465371250112 0.46631809543962 no 1791 0.471362018608705 2560 47811 A dopamine receptor agonist. SGTC_2127 5253358 187.912 µM -0.0728288945597344 0.465913663515201 no 1792 0.470971138735613 2533 20612 SGTC_865 0488-0499 301 µM -0.0728777395493342 0.465893555178435 no 1793 0.470951704048404 2522 9634651 SGTC_94 0334-0113 514.748 µM -0.0745528957578771 0.465203985694155 no 1794 0.470285226751938 2544 6795178 SGTC_454 lyso-paf C-16 6.67 µM -0.074557650417289 0.465202028610642 no 1795 0.470283335181718 2583 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2833 9001315 45.46 µM -0.0748185692524666 0.465094632104525 no 1796 0.470179533550073 2596 2989378 SGTC_1887 st057648 70.8 µM -0.075105412491446 0.464976567818227 no 1797 0.47006542072253 2609 688672 SGTC_215 1287-0124 461.5 µM -0.0753052988605018 0.464894296683339 no 1798 0.469985902787606 2622 5560863 SGTC_965 1291-5240 308 µM -0.07564706044456 0.464753634675038 no 1799 0.46984994743986 2578 2834598 SGTC_2012 4023501 200 µM -0.0760428044884443 0.464590760105573 no 1800 0.469692521853058 2586 3477460 SGTC_1807 st050092 58.9 µM -0.0768264825665854 0.464268242830238 no 1801 0.469380791476842 2546 5008496 SGTC_276 colchicine 750 µM -0.0772758095608619 0.464083335999082 no 1802 0.46920206726283 2652 2833 A microtubule depolymerizer. SGTC_626 0214-0009 33 µM -0.0773803199637458 0.464040329038292 no 1803 0.469160498114431 2618 3437874 SGTC_2706 st078239 82.5 µM -0.0791222401827694 0.463323575615855 no 1804 0.468467696929502 2554 15434492 SGTC_1248 0469-0687 58.6 µM -0.0791608247241701 0.463307700451613 no 1805 0.4684523520553 2612 4017482 SGTC_919 tnp00227 403.569 nM -0.0800112584834523 0.462957814178057 no 1806 0.468114150852747 2589 1269246 A methoxyflavone. YNL221C POP1 SGTC_635 k038-0028 24.7 µM -0.081138101720849 0.462494251435115 no 1807 0.467666062386686 2579 4035102 SGTC_2849 9019321 12.99 µM -0.0811535334820505 0.462487903442302 no 1808 0.467659926240143 2639 16489627 SGTC_1378 2093-0007 380 nM -0.0812715053678736 0.462439374969114 no 1809 0.467613017215975 2620 3618014 SGTC_67 0335-0847 266 µM -0.0815221546180516 0.462336270688863 no 1810 0.467513353338969 2874 4552207 YOR254C SEC63 SGTC_556 4058-0063 51.5 µM -0.0815756796991542 0.462314253536098 no 1811 0.46749207080567 2560 6615692 SGTC_3044 9093193 49.47 µM -0.0818000977058485 0.462221942079267 no 1812 0.467402839189041 2638 25236277 SGTC_982 1491-0518 27.5 µM -0.0823568890287227 0.461992921936885 no 1813 0.467181458556457 2606 3091256 SGTC_2019 4016004 108 µM -0.0829252060955996 0.461759174005707 no 1814 0.466955505748896 2603 45595336 SGTC_1975 st070967 30.8 µM -0.0851811074715309 0.460831456312462 no 1815 0.466058705019594 2569 261391 SGTC_1770 st043884 66.3 µM -0.0854027427829398 0.460740322344366 no 1816 0.465970606352953 2560 670149 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.0856712784272797 0.460629906245595 no 1817 0.465863867328387 2552 688803 SGTC_2388 9080168 200 µM -0.0869960970625824 0.460085213821584 no 1818 0.465337307219795 2557 15943073 SGTC_3179 9107801 49.47 µM -0.087037614025132 0.460068145539244 no 1819 0.465320806936008 2583 4818259 SGTC_1889 st059080 5.18 µM -0.0874737198343448 0.459888859970499 no 1820 0.465147486939138 2543 176925 Isolated from Daphnopsis sellowiana. SGTC_284 0988-0104 32.6 µM -0.0900441322470262 0.458832315759042 no 1821 0.464126072391379 2631 4666532 SGTC_2767 sibutramine 71.45 µM -0.090414794851628 0.458679982139458 no 1822 0.463978800127291 2623 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.0910071514471698 0.458436550105642 no 1823 0.46374345430354 2539 91467 include heat shock SGTC_3295 9122362 53.5725 µM -0.0913043091020156 0.458314437482216 no 1824 0.46362539706232 2627 4730473 SGTC_2667 digitoxin 100 µM -0.0919712171036712 0.458040395662271 no 1825 0.463360454033721 2601 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_170 4197-0004 226 µM -0.0929552896274512 0.457636062972223 no 1826 0.462969540537765 2681 218692 SGTC_2383 9036125 200 µM -0.0930558182075557 0.457594760559692 no 1827 0.462929608517456 2569 79580 SGTC_3025 9087895 49.47 µM -0.0933946764155491 0.457455543213873 no 1828 0.46279500981959 2601 17173641 SGTC_1246 0422-0085 105 µM -0.0935086346369741 0.457408725507972 no 1829 0.462749745152021 2599 264295 SGTC_3030 9087619 49.47 µM -0.093590156437545 0.457375234090557 no 1830 0.462717364658232 2589 25236973 SGTC_548 1436-0017 110 µM -0.0938901908656751 0.457251974232345 no 1831 0.462598192985502 2593 9677137 SGTC_287 k060-0039 29.6 µM -0.0941307510718247 0.457153150487034 no 1832 0.462502646501197 2636 5861974 SGTC_1488 4013-0813 75.9 µM -0.0946977779905166 0.456920222521351 no 1833 0.462277441477193 2558 2910057 SGTC_75 0159-0059 199.013 µM -0.0950979042035661 0.456755864297573 no 1834 0.462118531368212 2652 5377270 SGTC_998 3996-0085 177 µM -0.0951767283118724 0.456723486909198 no 1835 0.462087227088973 2623 715391 SGTC_1660 st012960 28.1 µM -0.0962460624696119 0.456284281142813 no 1836 0.461662574016607 2638 24207266 SGTC_664 1222-0054 14.9 µM -0.0963606859939027 0.456237205180982 no 1837 0.461617057404864 2605 6813991 SGTC_2743 auranofin 4.32 µM -0.0976361758224491 0.455713402212986 no 1838 0.461110598788668 2615 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_478 N-arachidonylglycine 10 µM -0.0980700426795833 0.455535244438765 no 1839 0.46093833765409 2587 5283389 SGTC_407 eburnamonine 100 µM -0.0991117280565785 0.455107536081207 no 1840 0.460524780148171 2574 3195 SGTC_963 1269-2853 151 µM -0.100528531464994 0.454525890624946 no 1841 0.459962366365535 2617 3668223 SGTC_114 0364-0001 490.298 µM -0.101162025913139 0.454265851312442 no 1842 0.459710920479613 2622 4003655 SGTC_2023 5144124 124 µM -0.101541129984344 0.454110244538204 no 1843 0.45956045462914 2607 2830192 SGTC_2182 6325192 200 µM -0.102947996799216 0.453532844790684 no 1844 0.459002122050717 2576 736248 SGTC_2299 7976368 114.88 µM -0.103973819017604 0.45311189344058 no 1845 0.458595062668124 2665 2979718 SGTC_2689 tacrolimus 100 µM -0.105813754833756 0.45235699874588 no 1846 0.457865061640759 2690 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2309 7664088 163.95 µM -0.106560294706052 0.452050754954904 no 1847 0.457568909701897 2628 704922 SGTC_2432 5630864 12.22 µM -0.107325646262774 0.451736823895969 no 1848 0.457265319636372 2714 5714970 SGTC_3081 9117243 49.47 µM -0.108761514042981 0.451147942799007 no 1849 0.456695825011456 2778 45595589 SGTC_29 0299-0004 12.984 µM -0.109148878059536 0.450989094617039 no 1850 0.456542203677283 2591 16871 A napthoquinone isolated from Swertia calycina. SGTC_77 0828-0286 12.516 µM -0.10947891463415 0.450853761159949 no 1851 0.456411322459311 2572 745345 SGTC_2931 9014674 55.67 µM -0.110558368306036 0.450411164756098 no 1852 0.455983281153059 2623 2996810 SGTC_357 1325-0123 420 µM -0.113188706258569 0.449332935770874 no 1853 0.45494047461273 2612 1098503 SGTC_2986 9022445 71.43 µM -0.113593544370288 0.449167017415032 no 1854 0.454780002536197 2617 6459286 SGTC_766 1391-0721 126 µM -0.115316829900664 0.448460847976193 no 1855 0.454096999510523 2765 1020919 YIL115C NUP159 SGTC_398 bronopol 33.3 µM -0.115454079717496 0.448404612617442 no 1856 0.454042608042146 2612 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1373 2887-0003 58.5 µM -0.117573634611154 0.447536299838131 no 1857 0.453202748276288 2709 776948 SGTC_2988 9073640 71.4286 µM -0.118058403300994 0.44733774102586 no 1858 0.453010691123408 2750 9102229 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.118443022608171 0.447180212283207 no 1859 0.452858319279073 2637 6708514 SGTC_903 1134-0042 114 µM -0.118649554876053 0.447095626184823 no 1860 0.452776501749805 2627 701009 SGTC_138 0850-0259 40.9225 µM -0.11951579164141 0.446740881785296 no 1861 0.452433364893096 2624 6813004 SGTC_1614 st002383 48.6 µM -0.119860802516761 0.446599603539566 no 1862 0.452296707808349 2625 1947235 SGTC_2267 7931562 200 µM -0.121019753352945 0.446125075351388 no 1863 0.451837694637348 2582 934880 SGTC_25 0118-0223 35.662 µM -0.121491208658111 0.445932061735482 no 1864 0.451650988799894 2657 5333628 SGTC_1033 k072-0102 21.3 µM -0.124292237552842 0.444785587324843 no 1865 0.450541946589729 2617 5965931 SGTC_1455 4262-0120 131 µM -0.125016078899381 0.444489390322286 no 1866 0.450255410541944 2825 1529587 SGTC_1140 3229-1848 2.98 µM -0.125182418462752 0.444421328288789 no 1867 0.450189567891185 2717 2849525 SGTC_2001 4023502 57.655 µM -0.125871089997555 0.444139558397307 no 1868 0.449916983735604 2717 108941 YCR052W RSC6 SGTC_2061 5245884 80.95 µM -0.126488073930586 0.443887143453718 no 1869 0.44967279442421 2644 573863 SGTC_476 mead acid 10 µM -0.127561479796608 0.443448055560383 no 1870 0.449248008345829 2629 5312531 An omega 9 fatty acid. SGTC_244 nsc-207895 1.295 µM -0.127628442885935 0.443420665903596 no 1871 0.449221510517188 2600 42640 SGTC_912 3474-0017 2.18 µM -0.128236588857723 0.443171930669439 no 1872 0.448980872686573 2777 3360550 SGTC_1022 4477-0945 21.3 µM -0.128989608715367 0.442863972213937 no 1873 0.448682935590328 2643 4648966 SGTC_1891 st059073 26.2 µM -0.129285065493562 0.442743150272212 no 1874 0.448566044132099 2775 688754 SGTC_2979 9012552 45.46 µM -0.131532773833142 0.441824163935754 no 1875 0.447676931007114 2690 17100905 SGTC_1943 st076331 65.2 µM -0.13211007104441 0.441588183531237 no 1876 0.447448615096946 2635 24208415 SGTC_2192 5915882 198.485 µM -0.132762288591777 0.441321603066433 no 1877 0.447190689812864 2638 2876149 SGTC_92 0063-0024 660.874 µM -0.1338444255957 0.440879360590873 no 1878 0.446762798338544 2588 3594437 SGTC_592 k241-0073 46.5 µM -0.134065621890307 0.440788972223973 no 1879 0.446675341971312 2685 4230158 SGTC_1075 aripiprazole 15.2 µM -0.134087426861536 0.440780062134347 no 1880 0.446666720884204 2629 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1525 8-methoxypsoralen 92.5 µM -0.135558479305318 0.44017902055048 no 1881 0.446085165543864 2755 4114 Related to psoralen; DNA damaging agent. SGTC_2887 9044784 58.44 µM -0.136873552533682 0.439641825476421 no 1882 0.445565372040076 2665 6465546 SGTC_350 k064-0020 19.8 µM -0.136950641977568 0.439610338600104 no 1883 0.445534904697889 2777 2790705 SGTC_3265 9137266 49.47 µM -0.137211860127783 0.439503647928577 no 1884 0.445431668276409 2613 17224265 SGTC_2845 9003024 42.97 µM -0.13744589362705 0.439408064155314 no 1885 0.44533917868446 2871 2990173 SGTC_648 0375-0473 33.3 µM -0.139393798790246 0.438612639873371 no 1886 0.444569486185073 2667 1713139 SGTC_2653 dihydrofissinolide 100 µM -0.14067906945709 0.438087936975713 no 1887 0.444061740395197 2689 6857746 SGTC_2437 5741531 144.16 µM -0.140901759324443 0.437997036406587 no 1888 0.443973776137581 2791 2262990 SGTC_1650 st011916 45.8 µM -0.142191510809355 0.437470632652585 no 1889 0.443464368525651 2687 242528 SGTC_1267 0828-0272 9.49 µM -0.142854594763227 0.437200042223402 no 1890 0.443202509405974 2755 745334 SGTC_2742 clothiapine 36.27 µM -0.143654199201398 0.436873779772455 no 1891 0.442886769850356 2659 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_689 0833-0039 98 µM -0.143948130467591 0.43675385783201 no 1892 0.442770714408111 2727 5374726 SGTC_1002 4049-0206 172 µM -0.143950726953375 0.436752798509502 no 1893 0.442769689236876 2667 4662749 SGTC_1954 st077032 68.9 µM -0.144217412561301 0.436643997685937 no 1894 0.442664395723011 2739 698907 SGTC_83 0170-0301 39.027 µM -0.145444642013011 0.436143381740353 no 1895 0.442179910068732 2650 3089716 SGTC_2418 pentamidine 31.67 µM -0.146526075939665 0.435702323989332 no 1896 0.441753053220941 2633 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3305 9127027 53.8275 µM -0.147400174833638 0.435345885267161 no 1897 0.441408083766318 2721 41905295 SGTC_1746 st038117 42 µM -0.147681327206233 0.435231248529055 no 1898 0.441297134381957 2771 2898218 SGTC_2252 omeprazole 400 µM -0.149187683375258 0.434617141579235 no 1899 0.440702769236454 2740 4594 A proton pump inhibitor. SGTC_747 3448-8087 38.7 µM -0.149534357094504 0.43447583290631 no 1900 0.440566000539994 2726 5168703 SGTC_1790 st045711 43.5 µM -0.150811972619266 0.433955132771193 no 1901 0.440062020754598 2712 585119 SGTC_2675 theaflavin digallate 100 µM -0.150916393394811 0.433912580489164 no 1902 0.440020834271573 2700 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_111 0083-0039 52.457 µM -0.151184288074085 0.433803414817919 no 1903 0.43991517206485 2658 759313 SGTC_2365 9042475 200 µM -0.15141231889349 0.433710497437322 no 1904 0.439825236212098 2752 6464479 SGTC_2812 7970281 58.44 µM -0.15150398644025 0.433673146025694 no 1905 0.439789083206397 2801 2233435 SGTC_318 1488-0629 67.2 µM -0.152153843872263 0.433408368198662 no 1906 0.439532798632639 2749 3662576 SGTC_406 estrone 100 µM -0.152462799894407 0.433282497671648 no 1907 0.439410964385121 2815 5870 A steroid. SGTC_1948 st076329 66.6 µM -0.153929784006859 0.432684932155694 no 1908 0.43883254986445 2654 24208413 SGTC_1709 st033179 39.1045 µM -0.154222649832848 0.432565653737687 no 1909 0.438717091925886 2680 573381 SGTC_787 4152-0075 138 µM -0.154262717884577 0.432549335295861 no 1910 0.438701296105607 2712 9566539 SGTC_56 0957-0365 83.25 µM -0.154359377749713 0.432509969283729 no 1911 0.438663190790068 2658 6752360 SGTC_1094 duloxetine 25.4 µM -0.155350322856107 0.432106432451889 no 1912 0.438272572612392 2661 60834 A selective serotonin reuptake inhibitor. SGTC_3221 9128209 49.47 µM -0.156027169362801 0.431830844853735 no 1913 0.43800580271566 2720 16460723 SGTC_2097 5376186 200 µM -0.156371153801857 0.431690799444289 no 1914 0.437870236690257 2750 742755 SGTC_514 4466-0038 2.65 nM -0.15664633553005 0.431578771667613 no 1915 0.437761791414011 2744 5722064 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.156953882229298 0.431453574471173 no 1916 0.437640597086592 2738 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1306 1185-0270 9.02 µM -0.158110882319982 0.430982640569702 no 1917 0.437184712812581 2777 1548076 SGTC_2337 9009472 200 µM -0.158921699473032 0.430652671985816 no 1918 0.436865282127264 2809 5742383 SGTC_1470 k295-0292 231 µM -0.16023678497196 0.430117590359373 no 1919 0.436347276767111 2792 5045612 SGTC_3160 9100216 49.47 µM -0.161028439942601 0.429795543808663 no 1920 0.436035500550183 2648 17191039 SGTC_63 0099-0242 26.702 µM -0.161167566336965 0.429738951780855 no 1921 0.435980712724257 2741 3898502 YLR359W ADE13 SGTC_368 fentichlor 4.58 µM -0.162048036227113 0.429380839198686 no 1922 0.435634013149668 2777 7329 A pesticide. SGTC_2147 5545932 89.7195 µM -0.162230291221499 0.429306718068086 no 1923 0.435562253403121 2719 797404 SGTC_707 0865-0008 204 µM -0.162544190357278 0.429179064536525 no 1924 0.435438666031867 2713 723043 SGTC_2783 7738165 71.43 µM -0.162547854152698 0.429177574622559 no 1925 0.435437223571171 2753 17201110 SGTC_774 k060-0086 136 µM -0.165237523749091 0.428084070943847 no 1926 0.434378515751796 2683 5911235 SGTC_2996 9066192 71.4286 µM -0.165665595485864 0.427910086139015 no 1927 0.434210061343226 2744 6472854 SGTC_3023 9089636 49.47 µM -0.165740774185364 0.427879532072254 no 1928 0.434180478320704 2683 17249241 SGTC_1089 terbinafine 2.25 µM -0.166039799332248 0.427758006794454 no 1929 0.434062814763404 2816 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2260 7964312 200 µM -0.167620981358205 0.427115520900472 no 1930 0.433440732002524 2906 231951 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.168798273156727 0.42663727423102 no 1931 0.43297765832829 2867 688751 SGTC_1137 ixabepilone 100 µM -0.169108163758901 0.426511406476714 no 1932 0.432855781831954 2693 154225 A novel microtubule stabilizer. SGTC_1603 st002045 67.8 µM -0.169322415036462 0.426424388764074 no 1933 0.432771522942349 2743 5887985 SGTC_2281 7943571 200 µM -0.169511848248066 0.426347453840627 no 1934 0.432697026833029 2814 1244024 SGTC_142 0335-0849 62.6745 µM -0.170451976358484 0.425965679085896 no 1935 0.432327349460382 2725 3889043 YPR107C YTH1 SGTC_2048 5246248 200 µM -0.171427405073325 0.42556964251939 no 1936 0.431943853793733 2755 677046 SGTC_2690 usnic acid 100 µM -0.171588349126412 0.425504304375347 no 1937 0.431880583824427 2888 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1409 3909-8004 61.9 µM -0.172767353056541 0.425025728939266 no 1938 0.4314171497974 2750 2119279 SGTC_2643 anethole 100 µM -0.173616322328814 0.424681187908566 no 1939 0.431083501737634 2738 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2641 levomentholum 100 µM -0.17398626004234 0.424531072399522 no 1940 0.430938130218501 2726 16666 SGTC_810 3825-7150 143 µM -0.174336040680032 0.424389146414778 no 1941 0.430800688272472 2872 22330411 YGL099W LSG1 SGTC_1405 3909-7894 12 µM -0.175532281810721 0.423903837261601 no 1942 0.4303307036589 2824 7104060 SGTC_234 nsc-17383 10.7 µM -0.175642872407475 0.42385897701499 no 1943 0.430287259299164 2774 408974 SGTC_1906 st060206 94.7 µM -0.175729363839206 0.423823893101601 no 1944 0.430253282632503 2842 5133468 SGTC_724 3910-0327 137 µM -0.177859478351925 0.422960036270831 no 1945 0.42941666748148 2771 2885483 SGTC_37 0566-0070 1.56 µM -0.178425458590118 0.422730568032348 no 1946 0.429194428510877 2828 1626686 SGTC_776 4476-4378 112 µM -0.178839916891461 0.42256254872508 no 1947 0.429031700687337 2812 2892008 SGTC_175 3793-3120 23.7 µM -0.179520729992466 0.422286581116 no 1948 0.428764420773797 2750 5322297 SGTC_3354 9151612 71.43 µM -0.179791984289254 0.42217663879904 no 1949 0.428657938342635 2846 27261949 SGTC_1625 st003711 30.1 µM -0.180339727867377 0.421954650862825 no 1950 0.428442934295305 2910 24207034 YER133W GLC7 SGTC_2247 cerulenin 830 nM -0.181077336498642 0.421655754154278 no 1951 0.428153436687999 2953 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_190 3970-0790 3.722 µM -0.181373394462722 0.421535797049417 no 1952 0.428037250333488 2699 2832352 SGTC_1086 cerivastatin 2.18 µM -0.181763566437669 0.421377717845011 no 1953 0.427884138972314 2715 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1759 st043059 70 µM -0.181788576142996 0.421367585528838 no 1954 0.427874325029022 2741 669426 SGTC_2306 7482397 179.52 µM -0.183085375092167 0.420842277908505 no 1955 0.427365515401371 2871 891448 SGTC_1985 st071382 65.5 µM -0.183379491192931 0.420723156860089 no 1956 0.42725013332888 2736 6123237 SGTC_764 1951-2361 146 µM -0.18411513494386 0.420425242873084 no 1957 0.426961566738566 2751 5438930 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.185742486505466 0.419766375729422 no 1958 0.426323354307969 2828 616764 SGTC_1431 4049-0260 9.09 µM -0.186113545836175 0.419616176049497 no 1959 0.426177859730374 2702 3854841 SGTC_3314 9135860 59.4275 µM -0.186810687280768 0.419334014528997 no 1960 0.425904533596875 2760 25252478 SGTC_3341 9147222 25.867 µM -0.186922228056294 0.419288873281981 no 1961 0.425860805442758 2855 1939759 SGTC_1092 toremifene 6.32 µM -0.187416054340144 0.419089031478132 no 1962 0.425667218037643 2718 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2899 9053889 58.44 µM -0.188215762909632 0.418765449409713 no 1963 0.425353758148528 2768 6470052 SGTC_3174 9107204 49.47 µM -0.188226764791721 0.418760998156039 no 1964 0.425349446095196 2859 3938802 SGTC_589 1227-0070 34.1 µM -0.190995864715683 0.417640979692545 no 1965 0.424264416499628 2867 2841384 SGTC_2803 7707263 71.43 µM -0.191582766072342 0.417403681030167 no 1966 0.424034521562146 2772 2199229 SGTC_1297 1068-0111 14.1 µM -0.191804565825058 0.417314009758574 no 1967 0.423947647179809 2729 767057 SGTC_1937 st074714 47.2 µM -0.192242645569666 0.417136911435014 no 1968 0.423776071253843 2720 17250970 SGTC_2656 pseudo-anisatin 100 µM -0.192368070518823 0.417086210180115 no 1969 0.423726950660865 2757 6708809 A neurotoxin. SGTC_2926 9010726 65.15 µM -0.194381036380096 0.416272686514255 no 1970 0.422938768752275 2858 2994293 SGTC_699 0375-0592 111 µM -0.195176130558454 0.415951454302804 no 1971 0.422627532379633 2797 762578 SGTC_3282 9108498 15.4605 µM -0.195964142979027 0.415633138643678 no 1972 0.422319115783286 2849 16459645 SGTC_763 3453-1109 128 µM -0.197252301577478 0.41511290946764 no 1973 0.42181505188703 2844 1560353 SGTC_811 0416-0114 265 µM -0.197608810930383 0.414968957665657 no 1974 0.421675570310549 2834 6612453 SGTC_1979 st071809 45.3 µM -0.198224243789181 0.414720484273207 no 1975 0.421434810010868 2890 4976333 SGTC_2983 9022671 12.99 µM -0.199186109038443 0.414332211457166 no 1976 0.421058582544762 2967 6405161 SGTC_939 1165-0479 45.3 µM -0.201205209221279 0.4135174409722 no 1977 0.420269059209809 2818 1377347 SGTC_1126 isoteolin 1.0172 µM -0.202059071777149 0.413172992341503 no 1978 0.419935271925473 2773 133323 SGTC_2276 7947513 42.08 µM -0.20215912457615 0.413132635355492 no 1979 0.419896163596587 2844 2105100 SGTC_1612 st002233 45.4 µM -0.202268430367278 0.413088547160526 no 1980 0.419853439390881 2746 1035021 SGTC_2193 5925765 200 µM -0.202455204889079 0.413013214699651 no 1981 0.419780437274201 2886 877370 SGTC_152 4469-0003 551.229 µM -0.203844649497181 0.412452905573406 no 1982 0.419237450030726 2764 697280 SGTC_2378 9074213 121.43 µM -0.204152150589025 0.412328926374256 no 1983 0.419117301056181 2772 657714 SGTC_1490 4089-0339 670 nM -0.205099577256094 0.41194699514004 no 1984 0.41874716335691 2785 742542 SGTC_1059 3448-6867 171 µM -0.205241925984153 0.411889618027689 no 1985 0.41869155720585 2725 3934407 SGTC_2831 7999036 19.48 µM -0.2064824559104 0.411389672177546 no 1986 0.418207033813425 3064 2988270 SGTC_1530 rhein 70.4 µM -0.206715699688584 0.411295688665975 no 1987 0.418115947820266 2757 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_412 gemfibrozil 100 µM -0.208489406331593 0.410581156220702 no 1988 0.417423426714083 2791 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1671 st016596 74.5 µM -0.208578082616541 0.410545441010478 no 1989 0.417388810894316 2807 2829167 SGTC_2027 5150920 200 µM -0.209620350333208 0.410125713529638 no 1990 0.416981997618886 2860 786715 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.210091802553741 0.409935890668114 no 1991 0.416798011661997 2917 61125 An anti-inflammatory. SGTC_13 0199-0087 65 µM -0.210649139611469 0.409711514845715 no 1992 0.416580532340082 2763 4589825 SGTC_2932 9016711 44.54 µM -0.211524315150296 0.409359241547953 no 1993 0.416239080339282 2881 7117328 SGTC_2095 5432005 200 µM -0.211683731953271 0.409295081396919 no 1994 0.41617689025881 2795 783734 SGTC_655 k060-0012 42 µM -0.211833822002401 0.409234677185769 no 1995 0.416118340555801 2796 5994525 SGTC_2210 7115885 190.385 µM -0.214255764379344 0.408260257805643 no 1996 0.415173805951618 2788 2927039 SGTC_2563 tomatine 8.54 µM -0.215282272871443 0.407847433674937 no 1997 0.414773624902089 2804 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1221 2958-7315 257 µM -0.216323629255196 0.407428742786229 no 1998 0.414367745805173 2887 4562705 SGTC_3254 9136651 49.47 µM -0.21648561351024 0.407363624398676 no 1999 0.414304619022656 2797 16454030 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.216504629359117 0.407355980111121 no 2000 0.414297208513264 2793 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2645 abamectin 100 µM -0.217320435268341 0.407028062988833 no 2001 0.413979316295537 2908 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2316 5844804 197.44 µM -0.217927631037818 0.40678404000333 no 2002 0.413742749027 2919 776813 SGTC_1779 st039427 55 µM -0.21864042127415 0.406497626346509 no 2003 0.413465081440273 2918 1124498 SGTC_423 5-fluorouracil 457 µM -0.218718093646979 0.406466419022073 no 2004 0.4134348267631 2741 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_432 NS 1619 61.3 µM -0.219218052925782 0.406265558847815 no 2005 0.413240096642889 2957 4552 A K+/calcium channel activator. SGTC_3074 9116018 49.47 µM -0.219247016056116 0.406253923576673 no 2006 0.413228816389967 2760 17027303 SGTC_698 k064-0052 127 µM -0.219466688223276 0.406165678034184 no 2007 0.413143263135929 2767 5088751 SGTC_2138 5575593 77.673 µM -0.219805814737954 0.406029455283156 no 2008 0.41301119543748 2802 762213 SGTC_2300 7976697 71.57 µM -0.219958676346856 0.405968056463179 no 2009 0.41295166901079 2808 2236109 SGTC_1949 st076024 69.1 µM -0.221741424531746 0.405252164009483 no 2010 0.412257590317354 2732 2921930 SGTC_1491 4138-0063 26.5 µM -0.22346473285749 0.404560441804049 no 2011 0.411586914121206 2786 23883227 SGTC_755 1995-0008 37.3 µM -0.224643350928487 0.404087525491351 no 2012 0.411128368764986 2813 689533 SGTC_2891 9063876 19.48 µM -0.22508302869723 0.403911142202469 no 2013 0.41095734169518 2912 6472478 SGTC_323 4013-0906 34.3 µM -0.225481594232237 0.403751268579068 no 2014 0.410802321199323 2905 2910086 SGTC_2133 5320837 200 µM -0.226423123420156 0.403373663892422 no 2015 0.410436172495077 2956 2841355 SGTC_1672 st016598 6.51 µM -0.227547331224902 0.402922913092304 no 2016 0.409999084663204 2862 4665860 YNL267W PIK1 SGTC_27 0485-0001 32.618 µM -0.227561079542112 0.402917401505561 no 2017 0.409993740059275 2771 2054479 SGTC_2749 bexarotene 57.39 µM -0.227708754145135 0.402858201194356 no 2018 0.409936333196124 2901 82146 An retinoic acid receptor inhibitor. SGTC_882 0843-0131 351 µM -0.229766211188966 0.402033632857241 no 2019 0.409136720935351 2803 5425421 SGTC_184 1494-0393 24.714 µM -0.230263464804949 0.401834413473401 no 2020 0.408943524352627 2784 3090647 SGTC_307 1501-1223 22.3 µM -0.230889278587942 0.4015837240774 no 2021 0.408700410083692 2885 2830329 SGTC_3283 9109332 35.8195 µM -0.233462634732529 0.400553312035868 no 2022 0.407701090543948 2790 17027281 SGTC_2287 7945887 168.79 µM -0.233485151389638 0.400544299056459 no 2023 0.407692349218872 2920 1245853 SGTC_692 k241-0027 77.8 µM -0.23403574729531 0.400323922726724 no 2024 0.407478613426414 2989 3600480 SGTC_482 fipronil 114 µM -0.23420693201593 0.400255412406398 no 2025 0.407412166849122 2801 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2989 9073649 71.4286 µM -0.234221805229011 0.40024946010069 no 2026 0.407406393830529 2795 21367202 SGTC_722 3534-0461 190 µM -0.234254294448761 0.400236457895417 no 2027 0.407393783251476 2867 658262 SGTC_1335 1486-0900 202 µM -0.235181236511052 0.399865541759733 no 2028 0.407034034353795 2793 X1335 SGTC_2096 5468907 200 µM -0.235395478553153 0.399779825584 no 2029 0.406950897543042 2967 759785 SGTC_1308 1187-1617 41.4 µM -0.235495630114576 0.399739757565942 no 2030 0.406912035080376 2798 2882570 SGTC_1686 st019653 115.5 µM -0.235544610483789 0.399720162186771 no 2031 0.406893029242423 2954 97252 SGTC_3308 9128332 17.569 µM -0.235634646137993 0.399684142643836 no 2032 0.406858093306582 2981 17332805 YDL196W YDL196W SGTC_1546 5-methoxyflavanone 78.7 µM -0.236914159298514 0.399172354736539 no 2033 0.406361692565163 2899 147795 SGTC_3078 9116413 49.47 µM -0.239379703655749 0.398186659736515 no 2034 0.40540558335408 2762 17177322 SGTC_1368 1852-0141 284 µM -0.241226109620154 0.397448913689062 no 2035 0.404689937880234 2942 2838987 SGTC_2322 7413319 38.22 µM -0.242735558513115 0.396846073775004 no 2036 0.404105129693797 2964 1840400 SGTC_3085 9117376 49.47 µM -0.243687211484069 0.396466131562948 no 2037 0.403736539299687 2912 16480349 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.244132782550635 0.396288273529354 no 2038 0.403563991866997 2952 7104 SGTC_1628 st004252 77.7 µM -0.245502687885558 0.395741585500586 no 2039 0.403033613607373 2996 692968 SGTC_2143 5623677 140.463 µM -0.245972094482 0.39555430655501 no 2040 0.402851917171148 2829 5375313 SGTC_2155 5570423 76 µM -0.24598940045519 0.395547402459078 no 2041 0.402845218829934 2852 797402 SGTC_277 nystatin 15.5 µM -0.246225782744202 0.395453102694807 no 2042 0.402753729042397 2799 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2853 9015042 58.44 µM -0.246388451806337 0.395388212833887 no 2043 0.402690772435412 2784 6457456 SGTC_2429 5902844 64.44 µM -0.247655204167004 0.394882995557006 no 2044 0.402200597067791 3013 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_825 1988-2224 89.6 µM -0.249784450369462 0.394034189442435 no 2045 0.401377022731843 2841 1180859 SGTC_252 miconazole 1.30953 nM -0.250208499643304 0.393865205706427 no 2046 0.401213056254353 2951 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3263 9137018 49.47 µM -0.250864908742878 0.393603665941699 no 2047 0.400959277878059 2901 43844957 SGTC_2723 salbutamol 83.58 µM -0.250913446133024 0.393584328599074 no 2048 0.400940514195762 2941 9884233 β2-adrenoceptor agonist SGTC_1721 st082152 9.2685 µM -0.251214694109423 0.393464316988535 no 2049 0.400824062256771 2794 5296051 SGTC_1919 st067113 52.3 µM -0.251406163945114 0.393388044214544 no 2050 0.400750051290155 2983 1268243 SGTC_467 ro 31-8220 72.8 µM -0.252338214140974 0.393016816778464 no 2051 0.400389826481679 2912 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_232 clozapine 119 µM -0.252972313695169 0.39276431605325 no 2052 0.400144803973223 2840 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2915 7971052 15.16 µM -0.253300084226973 0.392633814330904 no 2053 0.400018165512546 2861 5741558 SGTC_1983 st071813 46.9 µM -0.254299223750645 0.392236081812339 no 2054 0.399632199726663 2916 11838595 SGTC_2280 7785178 200 µM -0.255150848868945 0.391897159933653 no 2055 0.399303295881377 2872 2954328 SGTC_1870 st057514 26.5 µM -0.255728162966918 0.391667452442136 no 2056 0.39908037358466 2809 5393161 SGTC_2262 9014885 67.46 µM -0.255901273779087 0.391598580741789 no 2057 0.399013535516372 2863 6457424 SGTC_1511 0906-3109 28.5 µM -0.256173190387891 0.391490406264854 no 2058 0.398908554518007 2840 2882180 SGTC_2596 sinensetin 100 µM -0.257108613537932 0.391118338254737 no 2059 0.398547464187423 2911 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2113 5491891 107.031 µM -0.257206880623373 0.391079257935651 no 2060 0.398509536342145 2872 789979 SGTC_2231 micatex 6.853 µM -0.257723641878456 0.390873762725242 no 2061 0.398310099370487 2882 20737 An antifungal of unknown mechanism. SGTC_3350 9150499 3.57 µM -0.258520510035823 0.39055693997749 no 2062 0.398002611026582 2845 4910996 YPR165W RHO1 SGTC_88 0180-0332 8.668 µM -0.258594011479185 0.390527720569864 no 2063 0.397974252136005 2826 3101745 SGTC_2227 7312221 64.1025 µM -0.259593514170835 0.390130444543083 no 2064 0.397588669902812 2858 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2826 7992541 19.48 µM -0.259848510851572 0.390029108421471 no 2065 0.397490314793827 2809 2985066 SGTC_716 1683-5115 658 µM -0.260082843687582 0.389935990736574 no 2066 0.397399935709837 2836 723597 SGTC_86 0417-1630 471.922 µM -0.2613120575609 0.389447637162746 no 2067 0.396925934466678 2906 3634867 SGTC_624 k048-0052 28 µM -0.26175941068318 0.38926995181094 no 2068 0.396753466890541 2917 6835531 SGTC_1146 3579-1023 7 µM -0.26249059286961 0.388979581512046 no 2069 0.396471618488348 2976 X1146 SGTC_1272 0839-0021 27 µM -0.264439814041102 0.38820580155404 no 2070 0.395720517935082 2956 5027250 SGTC_208 k072-0098 12.366 µM -0.264535649910621 0.388167769120749 no 2071 0.395683599108662 2858 5948901 SGTC_1461 k072-0203 53.8 µM -0.265210214617811 0.387900098699502 no 2072 0.395423763224058 2837 5418714 SGTC_2586 curcumin 80 µM -0.265366339777228 0.387838155092888 no 2073 0.395363631923112 2988 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_3346 9158254 43.5805 µM -0.265678849500333 0.387714173535231 no 2074 0.395243276897519 2959 17639500 SGTC_3122 9126309 49.47 µM -0.266469307784435 0.387400627218779 no 2075 0.394938896989485 2925 17591206 SGTC_3270 9137563 49.47 µM -0.266966192437544 0.387203568558078 no 2076 0.394747595590208 2983 17015724 SGTC_2110 5483698 200 µM -0.268855466316797 0.386454570313851 no 2077 0.39402045411073 2931 2848765 YHR062C RPP1 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.269256215046325 0.386295748675913 no 2078 0.393866261805425 2923 688788 SGTC_3248 9135562 49.47 µM -0.269907963317797 0.386037493532831 no 2079 0.393615530316909 2934 17650701 SGTC_738 1315-0003 72.4 µM -0.271305777554214 0.385483780283733 no 2080 0.393077931607772 3042 6251474 SGTC_2824 7998404 51.95 µM -0.272883531154063 0.384859068378247 no 2081 0.392471373239042 2869 837851 SGTC_3293 9120939 62.045 µM -0.274769442394488 0.384112733514456 no 2082 0.391746688109072 3039 934087 SGTC_253 dyclonine 31.25 µM -0.274782140914023 0.384107709625784 no 2083 0.391741809812901 2902 3180 An oral anasthetic. SGTC_3018 9082602 49.47 µM -0.275629864316551 0.383772370672463 no 2084 0.391416184727914 2890 17332089 SGTC_3216 9129716 49.47 µM -0.276297208739676 0.383508446499322 no 2085 0.39115989980594 2919 8056934 SGTC_2856 9022925 19.48 µM -0.276811523667628 0.383305079940574 no 2086 0.390962416100663 3061 4944862 SGTC_3252 9135871 49.47 µM -0.277092941240053 0.383193817516221 no 2087 0.390854370887126 3038 17682838 SGTC_1321 1326-2144 215 µM -0.277291681663605 0.383115248477997 no 2088 0.390778073152652 3016 3513030 SGTC_309 k408-0051 1.48 µM -0.277341147212217 0.383095693764267 no 2089 0.390759083661869 2929 3640463 SGTC_1883 5-benzylidenerhodanine 20 µM -0.277460852216568 0.383048373231592 no 2090 0.390713130795453 3010 1273210 SGTC_2939 9044578 71.43 µM -0.279060117363756 0.382416336103531 no 2091 0.390099344730204 2874 2653634 SGTC_802 4112-3352 742 µM -0.279172319946628 0.382372004848796 no 2092 0.390056292477909 3048 704594 SGTC_358 0075-0058 9.45 µM -0.27931005339022 0.382317588455552 no 2093 0.390003445850547 2841 1069125 SGTC_2393 9031399 185.94 µM -0.280817225589786 0.381722279671007 no 2094 0.389425295465222 3058 1526623 YDL150W RPC53 SGTC_2090 5301565 104.445 µM -0.281135427235358 0.381596630840765 no 2095 0.389303264734729 2909 2056344 SGTC_1863 st057641 20.1 µM -0.282003274847707 0.38125400581204 no 2096 0.388970499604794 2901 3921635 SGTC_202 3594-0513 34.79 µM -0.282026639519727 0.381244782757238 no 2097 0.388961541843076 2897 708429 SGTC_2518 prenyletin 46.28 µM -0.284089617638934 0.380430701802369 no 2098 0.388170851624577 3010 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1199 1638-0010 4.46 µM -0.284498659177416 0.380269350865851 no 2099 0.38801413071244 2886 3111136 SGTC_2346 9031566 143.75 µM -0.28494217670135 0.380094424037637 no 2100 0.387844221217114 3009 4771086 SGTC_2479 5617353 43.85 µM -0.285745350044602 0.379777708545036 no 2101 0.387536583923573 3066 2731746 SGTC_908 3448-7491 47.7 µM -0.287271995108321 0.379175928751476 no 2102 0.386952032003084 2901 1203031 SGTC_2102 5377816 72.7585 µM -0.289040014467946 0.378479368766129 no 2103 0.386275378317736 3102 1379702 SGTC_1552 6-methylflavone 10.6 µM -0.289247853064861 0.37839751090006 no 2104 0.386195857315961 2941 689013 SGTC_3171 9103192 49.47 µM -0.289490464798744 0.378301964430685 no 2105 0.386103037832206 3002 13018434 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.290136495525968 0.378047577939138 no 2106 0.385855908307121 3046 6708760 SGTC_1189 1431-2119 7.28 µM -0.290828949870811 0.37777496999459 no 2107 0.385591071543389 2929 3107275 SGTC_727 3032-0951 202 µM -0.291418950483733 0.37754274442265 no 2108 0.385365461406397 2972 3652836 SGTC_760 0568-0725 82.9 µM -0.293232959314124 0.376829024043603 no 2109 0.384672046446289 3064 3916171 SGTC_3188 9110789 49.47 µM -0.294303955379082 0.376407838826518 no 2110 0.384262825236065 3098 849217 SGTC_780 0109-0199 192 µM -0.295165200484414 0.376069248001276 no 2111 0.383933842149128 3111 610414 SGTC_751 0833-0568 350 µM -0.296816937005007 0.375420149588114 no 2112 0.383303137013181 3012 6954252 SGTC_2505 galangin 7.89 µM -0.300717577364192 0.373888680520179 no 2113 0.38181493202654 2891 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3073 9114972 49.47 µM -0.302499828208429 0.373189593781476 no 2114 0.381135532196628 3058 41905075 SGTC_115 0527-0192 112.043 µM -0.302845970374227 0.373053868059566 no 2115 0.381003624079908 3021 4233931 SGTC_1064 honokiol 6.76 µM -0.3041999697339 0.372523103173764 no 2116 0.380487773947963 3018 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.306229698918377 0.371727907174499 no 2117 0.379714880713944 2988 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3207 9114163 49.47 µM -0.306653936026728 0.371561770919557 no 2118 0.3795533975833 3211 849233 SGTC_107 0358-0022 2.6945 µM -0.306840343201603 0.371488779234329 no 2119 0.379482449530753 3023 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_854 0422-0053 192 µM -0.307461491515954 0.371245588796115 no 2120 0.379246064846947 2971 3596728 SGTC_2136 5328288 199.296 µM -0.308288303874673 0.370921957041332 no 2121 0.378931482542882 2973 262395 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.308612544179549 0.370795067468464 no 2122 0.378808138745946 3131 94937 An inhibitor of serotonin biosynthesis. SGTC_1318 1280-3875 124 µM -0.309296489119915 0.370527455654084 no 2123 0.378548000704093 3012 373245 SGTC_608 k048-0125 159 µM -0.309811710608901 0.370325902776409 no 2124 0.378352072855833 3071 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1904 st060225 78 µM -0.31033583377496 0.37012090411691 no 2125 0.378152791975048 2960 66595 SGTC_1796 st049173 110.4 µM -0.314491849487104 0.368496685056196 no 2126 0.376573752923242 3069 94134 SGTC_2 0422-0095 29 µM -0.314924591496128 0.368327698879734 no 2127 0.376409454807586 3002 6790840 SGTC_1384 3089-0840 101 µM -0.315478953242969 0.368111257291221 no 2128 0.376199014334929 3085 1069836 SGTC_1184 1269-1718 139 µM -0.316068121197455 0.367881272065206 no 2129 0.375975401467716 3107 5403821 SGTC_2352 9027995 87.8 µM -0.316963964029802 0.367531665240429 no 2130 0.375635472994919 3008 2997347 SGTC_219 mitoxanthrone 164.414 µM -0.317229701408495 0.367427981089013 no 2131 0.375534657225462 3004 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1396 3511-0007 98.6 µM -0.317724819053911 0.367234824214469 no 2132 0.375346841564676 3068 X1396 SGTC_2304 7443016 91.4 µM -0.31806154774579 0.367103477733259 no 2133 0.375219125320332 2898 939854 SGTC_1819 st053448 58.6 µM -0.318348076495024 0.366991724799604 no 2134 0.375110459947086 2977 2857616 SGTC_2951 9072950 58.06 µM -0.319033962966604 0.36672425877893 no 2135 0.374850379346075 2979 16488155 SGTC_3105 9121040 49.47 µM -0.32119517249913 0.365881904310908 no 2136 0.374031245139681 2993 41448907 SGTC_1647 st011722 22.4 µM -0.321824192937315 0.365636858103348 no 2137 0.373792942618649 3124 2854783 SGTC_2651 TUB2.036 5 µM -0.322122634676108 0.365520613934071 no 2138 0.373679895720811 3120 15992207 YFL037W TUB2 SGTC_2765 myclobutanil 7.74 µM -0.322807076871728 0.365254067805202 no 2139 0.373420676568648 3072 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1809 st050081 57.6 µM -0.324381950413007 0.364641003378632 no 2140 0.37282444154374 3147 5036894 SGTC_2910 7948405 25.97 µM -0.325198004105199 0.364323467205902 no 2141 0.372515609577823 3147 2971328 SGTC_3145 9085516 49.47 µM -0.326379889912347 0.36386374651859 no 2142 0.372068475375164 3077 25236195 SGTC_2376 9072922 81.32 µM -0.326450454747178 0.363836304952161 no 2143 0.372041784547734 3099 17087968 SGTC_630 4356-0227 183 µM -0.32656337226809 0.36379239453798 no 2144 0.371999075288833 3004 779312 SGTC_1682 st012968 530 nM -0.327070999691344 0.363595014766669 no 2145 0.371807092739236 2983 24207270 SGTC_255 tunicamycin 200.472 nM -0.327333669788494 0.363492895478923 no 2146 0.371707764527021 3050 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_733 4069-0007 56.1 µM -0.328642833344882 0.362984071577809 no 2147 0.371212834218312 3011 5717425 YNL287W SEC21 SGTC_2520 obtusaquinone 4.71 µM -0.33045693772695 0.362279395457748 no 2148 0.37052736269782 3143 5967872 SGTC_1197 1601-0112 267 µM -0.332329938513497 0.361552330812357 no 2149 0.369820067826007 2980 7350313 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.33247620215971 0.36149557493782 no 2150 0.369764853284339 2915 4000243 SGTC_2623 humulene 100 µM -0.333605537943845 0.361057452263808 no 2151 0.369338619388774 3072 6187145 An anti-inflammatory. SGTC_1392 3455-1037 33.9 µM -0.334652509949851 0.360651445136524 no 2152 0.368943614636037 3150 981132 SGTC_2766 oltipraz 83.91 µM -0.334976577670669 0.36052580614436 no 2153 0.368821377416117 3139 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2960 9079389 5.97 µM -0.335239712330171 0.360423801587187 no 2154 0.368722133695991 3155 16457355 SGTC_2502 avocadyne acetate 18.59 µM -0.335724380207894 0.360235945337621 no 2155 0.368539359548378 2921 3952079 SGTC_1185 1319-0113 81.3 µM -0.336886016395709 0.359785835015694 no 2156 0.368101413545912 3096 4672763 SGTC_2770 toltrazuril 17.5 µM -0.337268778551241 0.359637565039799 no 2157 0.367957146701938 3045 68591 Kills coccidiodes. SGTC_870 0573-2213 57.6 µM -0.342527445973747 0.357602670824343 no 2158 0.365976996429008 2997 3916321 SGTC_2612 dictamnine 15.46 µM -0.343612229496148 0.357183403850302 no 2159 0.365568963167536 3084 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1989 st071868 50.2 µM -0.34388930812087 0.357076341054262 no 2160 0.365464766465539 3148 16414057 SGTC_1714 st033236 13.627 µM -0.344620715299715 0.356793780414322 no 2161 0.365189765114237 3206 2916566 SGTC_433 pimozide 108 µM -0.346539715364772 0.356052797124043 no 2162 0.364468571224473 2968 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_796 1234-0020 70.7 µM -0.346570209747554 0.356041026709721 no 2163 0.364457114764149 3010 46495034 SGTC_3037 9091026 49.47 µM -0.346973159949772 0.355885506335689 no 2164 0.364305741437609 3102 25236398 YIL048W NEO1 SGTC_310 1273-0058 1.06 µM -0.347025085976244 0.355865467004724 no 2165 0.364286236309539 3115 2734232 SGTC_2640 pentamidine 10.38 µM -0.348237632501271 0.355397633478713 no 2166 0.363830863873349 3126 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3236 9132701 49.47 µM -0.348264689949247 0.355387196459068 no 2167 0.363820704626203 3081 24282524 SGTC_2594 a-mangostin 100 µM -0.349360007502316 0.354964784676188 no 2168 0.363409526713445 3162 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_382 3229-0966 23.2 µM -0.349784525723729 0.354801116119802 no 2169 0.363250206514878 3188 5722370 SGTC_1150 3909-7983 10.9 µM -0.349996707583155 0.354719321666735 no 2170 0.363170584272732 3044 23965914 SGTC_1088 bifonazole 369 nM -0.350493143631243 0.354527975611145 no 2171 0.362984317413309 3094 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_162 k030-0015 37.8 µM -0.351521797161812 0.354131608797526 no 2172 0.362598461398922 3099 1809920 YMR134W ERG29 SGTC_1319 1306-0155 43.7 µM -0.352358948941322 0.353809149147544 no 2173 0.362284542138731 3025 3122360 SGTC_1951 sophoraflavanone G 9.2 µM -0.352772871062069 0.353649750614206 no 2174 0.362129361795996 3040 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3266 9136860 49.47 µM -0.352952266042224 0.353580674821488 no 2175 0.362062113247307 3122 4871271 YPR165W RHO1 SGTC_3195 9113082 49.47 µM -0.353309212404593 0.353443247453252 no 2176 0.361928319913059 3120 17018038 SGTC_1693 xanthone 101.9 µM -0.35387689621363 0.353224723743366 no 2177 0.361715571135718 3046 7020 An insecticide. SGTC_1995 st072814 61.1 µM -0.35464994751469 0.352927223869279 no 2178 0.361425926270005 3036 5769371 SGTC_702 1488-0190 94 µM -0.354820147788162 0.352861736325781 no 2179 0.361362166730532 3121 949357 SGTC_207 4185-0010 4.486 µM -0.354918303188986 0.352823971293618 no 2180 0.361325398016248 3115 3761753 SGTC_1910 st062352 60.4 µM -0.355087136653816 0.352759016454705 no 2181 0.36126215651101 2959 2245730 SGTC_2858 9025781 8.96 µM -0.355277024270672 0.352685966637413 no 2182 0.361191033088201 3113 4894980 YPL153C RAD53 SGTC_263 alizarin 107.927 µM -0.356142980191133 0.352352902061955 no 2183 0.360866745531207 3074 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2389 9091542 195.52 µM -0.356492957012962 0.35221832583384 no 2184 0.360735712800605 3074 3626624 YOL127W RPL25 SGTC_2905 7799065 20.05 µM -0.356857582870041 0.352078136308323 no 2185 0.360599212800332 3205 1296806 SGTC_617 3770-0098 35 µM -0.357797448333912 0.351716874262712 no 2186 0.360247450135883 3050 5962639 SGTC_2625 euphol 100 µM -0.357953073751627 0.351657068443056 no 2187 0.360189215746331 3177 6708538 A triterpene alcohol. SGTC_2867 9039098 71.43 µM -0.358608933768152 0.351405066125129 no 2188 0.35994383129026 3001 6463460 SGTC_2490 carminic acid 95.39 µM -0.360093402029281 0.350834927439548 no 2189 0.359388643359897 3004 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_374 0880-0231 82.3 µM -0.360952434178209 0.350505152823489 no 2190 0.359067502642161 3092 6833587 SGTC_2142 5622915 118.518 µM -0.362043284751243 0.350086547584142 no 2191 0.358659842400831 3076 5322196 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.362499117912029 0.349911679145417 no 2192 0.358489541289272 3065 6708630 An antioxidant. SGTC_1567 st069303 68.4 µM -0.362795433424694 0.349798022536759 no 2193 0.358378851704719 3136 5581319 SGTC_1734 st037168 69.4 µM -0.363781188341261 0.349420017200381 no 2194 0.358010705559299 3126 708907 SGTC_2762 leflunomide 42.06 µM -0.363914771360663 0.34936880388267 no 2195 0.357960826964805 3031 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1936 st074407 74.3 µM -0.364789805358426 0.349033399498914 no 2196 0.357634157815037 3048 809813 SGTC_2088 5278280 127.392 µM -0.36537078032614 0.348810774346854 no 2197 0.357417324848953 3138 791502 SGTC_1432 4049-0298 68.4 µM -0.365744022957243 0.348667778084856 no 2198 0.357278046554696 3143 741646 SGTC_1011 4112-3381 17.4 µM -0.366529092069303 0.348367073546801 no 2199 0.356985154182856 3211 2877139 SGTC_3093 9117344 49.47 µM -0.366729585063959 0.348290294104771 no 2200 0.356910368068099 3172 24824913 SGTC_607 4491-0986 66.8 µM -0.367123793668651 0.348139348773077 no 2201 0.356763339914984 3187 698981 YDR232W HEM1 SGTC_2010 4012422 159 µM -0.369754035417964 0.347132826863189 no 2202 0.355782883059961 3107 952393 SGTC_2745 rifampicin 24.3 µM -0.370125736603133 0.346990673663515 no 2203 0.355644403329009 3099 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_731 3966-0296 387 µM -0.37134287211597 0.346525343791358 no 2204 0.355191084865684 3044 660956 SGTC_823 0417-1665 178 µM -0.371468925122907 0.346477164980077 no 2205 0.355144148498066 3124 3429856 SGTC_399 oxolinic acid 75 µM -0.372995350048113 0.345893946329227 no 2206 0.354575952383639 3064 4628 A DNA gyrase inhibitor. SGTC_2937 9044753 11.33 µM -0.373297273681 0.345778630156563 no 2207 0.354463602665185 3006 6465530 YGL099W LSG1 SGTC_197 4544-0043 41.561 µM -0.373898079595358 0.34554920198608 no 2208 0.354240072630948 3052 896523 SGTC_2399 5884133 200 µM -0.373927274813823 0.345538054729506 no 2209 0.354229211819113 3061 722445 SGTC_3169 9102970 49.47 µM -0.374391732579748 0.345360734468928 no 2210 0.354056446450641 3117 17027839 SGTC_2551 apiole 73.87 µM -0.37707671508541 0.344336330503278 no 2211 0.353058297417785 3033 10659 A possible DNA adduct former. SGTC_1404 3909-7820 48.3 µM -0.378840886000444 0.343663865248615 no 2212 0.352403011896726 3176 23741373 SGTC_155 k072-0202 43.6 µM -0.378848819071577 0.343660842442003 no 2213 0.352400066215823 3152 5857737 SGTC_1924 st058459 75.1 µM -0.379002439746577 0.343602309000639 no 2214 0.352343026056792 3130 688683 SGTC_3303 9125618 40.5795 µM -0.38002406195728 0.343213140022845 no 2215 0.351963776927878 3128 22695467 SGTC_978 1416-0512 87.4 µM -0.380956956235466 0.342857915556548 no 2216 0.351617594182101 3159 6814003 SGTC_1881 5652484 16 µM -0.382436896653007 0.342294673627265 no 2217 0.351068663470848 3204 2255129 SGTC_3210 9128157 49.47 µM -0.38298558974639 0.342085938735165 no 2218 0.350865224357053 3140 17590849 SGTC_1240 0356-0016 42.1 µM -0.383219296863347 0.341997046068008 no 2219 0.35077858567262 3110 4305613 SGTC_296 1222-0039 74.9 µM -0.383280181830081 0.341973889344541 no 2220 0.35075601598889 3105 5984176 SGTC_3334 9142812 21.919 µM -0.384842452517175 0.341379905634725 no 2221 0.350177072169178 3178 45283678 SGTC_2977 9011197 71.43 µM -0.385327600748051 0.341195529513572 no 2222 0.34999735745102 3266 2704722 SGTC_3196 9111891 49.47 µM -0.386671633540628 0.340684940305661 no 2223 0.349499659449439 3094 18891510 SGTC_1347 1493-0251 600 nM -0.387382605081798 0.340414964830118 no 2224 0.34923648980612 3204 3986378 SGTC_59 0330-0160 1.33 µM -0.38756100800866 0.340347233152387 no 2225 0.349170464447389 3132 4293482 SGTC_1145 3546-0597 10.2 µM -0.387646301265827 0.340314852905597 no 2226 0.349138899773735 3121 875334 SGTC_3084 9116877 49.47 µM -0.388688028032192 0.339919472748347 no 2227 0.348753469801513 3151 27241325 SGTC_984 1492-0255 2.91 µM -0.389237580043875 0.339710964991491 no 2228 0.348550203114342 3187 1585198 SGTC_3082 9117008 49.47 µM -0.390540621903482 0.339216768683399 no 2229 0.348068411659825 3121 41448529 SGTC_892 0929-0076 29 µM -0.392203284724913 0.338586582755373 no 2230 0.347454008655441 3109 5751038 SGTC_1244 0416-0015 52.5 µM -0.392895459844829 0.338324366154606 no 2231 0.347198347506146 3097 96201 SGTC_2420 aureobasidin a 50 nM -0.3930997322922 0.338246996627393 no 2232 0.347122910908346 3329 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3349 9149703 23.001 µM -0.394560006857267 0.337694107162228 no 2233 0.346583816794493 3085 4910494 SGTC_379 3970-0972 5.9 µM -0.394793851544534 0.337605601327331 no 2234 0.346497516441273 3143 2898042 YBL034C STU1 SGTC_2810 7959871 45.46 µM -0.396016615947781 0.337142954261016 no 2235 0.346046385224468 3187 2974535 SGTC_3348 9149464 3.537 µM -0.396699559544918 0.336884661751004 no 2236 0.345794512509983 3125 1951442 SGTC_1391 3442-0225 151 µM -0.397549628614032 0.336563269037525 no 2237 0.345481098486942 3071 5227075 SGTC_569 4130-2812 160 µM -0.397985860449644 0.336398385548661 no 2238 0.345320304219494 3159 743552 SGTC_2735 sertaconazole 140 nM -0.398893125434103 0.336055565421668 no 2239 0.344985977410214 3160 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1510 1123-0200 71.5 µM -0.399288182860279 0.335906331183296 no 2240 0.344840436688283 3314 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1462 k081-0014 26.5 µM -0.399373637435998 0.335874053839148 no 2241 0.344808957903019 3104 3270634 SGTC_2710 st078562 53.7235 µM -0.399567646538721 0.335800778482308 no 2242 0.344737495023466 3059 17250908 SGTC_2821 7996764 71.43 µM -0.400415926628538 0.33548046466055 no 2243 0.344425097777313 3314 2987135 SGTC_1739 st037196 92.5 µM -0.400913190640108 0.335292751418518 no 2244 0.344242019005127 3272 612214 SGTC_1848 st056003 16.4 µM -0.401064886872138 0.335235495470253 no 2245 0.344186175936597 3214 146492 SGTC_972 1319-0219 195 µM -0.402120245903162 0.334837268693609 no 2246 0.343797766731971 3164 23903702 SGTC_1228 0124-0032 52.5 µM -0.403537686845466 0.334302706930703 no 2247 0.343276358035703 3194 X1228 SGTC_994 3910-0338 138 µM -0.403681478751703 0.334248497205761 no 2248 0.343223480516685 3285 3479481 SGTC_1756 st041558 35.5 µM -0.404738728671614 0.333850018905856 no 2249 0.34283478553609 3292 3955792 SGTC_2030 5175110 200 µM -0.405020964737237 0.333743675571797 no 2250 0.342731050340919 3245 2831986 SGTC_2018 5133068 143 µM -0.406415807728763 0.333218310840116 no 2251 0.342218553354082 3066 785362 SGTC_269 exalamide 29 µM -0.40668267254695 0.333117834001372 no 2252 0.342120534234908 3118 3316 A derivative of salicylamide. SGTC_347 4534-1311 26.2 µM -0.406800856025992 0.333073340758206 no 2253 0.342077128986759 3113 2862016 SGTC_1830 st055982 50.3 µM -0.406969076704566 0.333010013762974 no 2254 0.34201535017473 3231 455313 An antimicrobial agent. SGTC_644 1498-1197 63.3 µM -0.408112708943018 0.332579617537981 no 2255 0.341595464999301 3222 6741615 SGTC_3355 9151058 44.0485 µM -0.409182466438306 0.332177223100038 no 2256 0.341202880317618 3220 17015728 SGTC_502 l-744,832 89.3 µM -0.409451648547097 0.332075999392746 no 2257 0.341104121630334 3227 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_3218 9131285 49.47 µM -0.410131035285926 0.331820576124299 no 2258 0.340854913723462 3300 17156417 SGTC_2794 7785382 27.27 µM -0.41071143070684 0.331602431676861 no 2259 0.340642072109577 3244 2205081 SGTC_2955 9076254 12.21 µM -0.412555504336144 0.330909706841749 no 2260 0.339966153529063 3221 16459619 SGTC_1198 1612-1005 86.7 µM -0.412970211095949 0.330754002166534 no 2261 0.339814219479826 3293 6998509 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.414819057262716 0.330060195950177 no 2262 0.339137183786356 3120 16486 A toxic proline analog. SGTC_1621 st003705 32.4 µM -0.415651848429071 0.329747869684449 no 2263 0.338832390403949 3274 24207032 SGTC_137 0438-0332 85.389 µM -0.415917135788297 0.329648402416533 no 2264 0.338735319982896 3238 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_3344 9148862 3.898 µM -0.416456993810261 0.329446024397202 no 2265 0.338537815397157 3282 4905352 SGTC_2449 5812982 45.77 µM -0.416665083736161 0.329368030504074 no 2266 0.338461698503118 3222 776185 SGTC_1929 genistein trimethyl ether 50.5 µM -0.416670889463468 0.329365854574004 no 2267 0.338459574929669 3318 136420 SGTC_1330 1469-0054 61.8 µM -0.41737174303978 0.329103223950231 no 2268 0.338203259957639 3264 7102664 SGTC_2430 5571206 200 µM -0.418238967232301 0.328778366057682 no 2269 0.337886203990395 3295 1731771 SGTC_678 1218-2179 85.9 µM -0.418950726798055 0.328511841058661 no 2270 0.337626071574768 3210 6820081 YOR116C RPO31 SGTC_792 4534-1957 155 µM -0.419031067547633 0.328481762193028 no 2271 0.337596713672881 3133 1717904 SGTC_1856 st057054 55.7 µM -0.419441480541539 0.328328124545768 no 2272 0.337446757077335 3334 1266018 SGTC_1963 st076565 50.3 µM -0.419892928224287 0.328159159136044 no 2273 0.337281837050523 3131 4914280 SGTC_235 0330-0087 5 mM -0.422697019752067 0.327110447275745 no 2274 0.336258165135013 3173 46494818 YHR062C RPP1 SGTC_873 0591-4978 488 µM -0.423220828167219 0.32691469726629 no 2275 0.33606707593606 3334 3305145 SGTC_540 1187-0821 17.3 µM -0.423274241378771 0.326894739137748 no 2276 0.336047592779005 3161 847520 SGTC_840 0245-0196 390 µM -0.42385369997479 0.326678253209413 no 2277 0.335836256110092 3288 3827528 SGTC_3148 9097893 49.47 µM -0.424043582879181 0.326607325580114 no 2278 0.335767014441424 3113 17174100 SGTC_1500 4488-1866 171 µM -0.424216118203879 0.326542883287507 no 2279 0.33570410348119 3293 2900003 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.424559124000575 0.326414785303476 no 2280 0.335579048138191 3280 5377381 SGTC_728 3030-5151 22.5 µM -0.424856965329308 0.326303570918372 no 2281 0.335470473929208 3144 3125388 SGTC_1190 1486-1332 13 µM -0.426367035692662 0.325739946242425 no 2282 0.334920208847712 3202 4150046 SGTC_894 0960-0238 55.9 µM -0.426395564059795 0.32572930202855 no 2283 0.334909816602341 3273 6741907 YDL195W SEC31 SGTC_176 1486-1328 72.834 µM -0.426687186068663 0.325620503144057 no 2284 0.334803592486226 3215 22310231 SGTC_3238 9133470 49.47 µM -0.427075648427222 0.325475597953224 no 2285 0.33466211453752 3280 3534688 SGTC_2496 diffractaic acid 79.83 µM -0.427656877072334 0.325258835864939 no 2286 0.334450474962362 3367 94870 An apoptosis inducer which activates caspases. SGTC_1390 3413-2614 145 µM -0.42789513262235 0.325169998459462 no 2287 0.334363735482064 3199 3421432 SGTC_354 2783-3500 4.88 µM -0.433847388060045 0.322953840536649 no 2288 0.332199633565987 3170 6740761 SGTC_2092 5303694 80.6725 µM -0.433903985488005 0.32293279802662 no 2289 0.33217908274373 3172 1963699 SGTC_986 1493-0483 84 µM -0.434600050569314 0.322674052484641 no 2290 0.331926379157378 3270 40079 SGTC_1134 3477-0009 42.5 µM -0.43646254182552 0.321982138317079 no 2291 0.331250585458508 3369 3973534 SGTC_627 1391-0720 175 µM -0.436506778609173 0.321965711871779 no 2292 0.331234541077589 3228 997839 SGTC_418 lividomycin a 100 µM -0.437499882200043 0.32159703431894 no 2293 0.330874430747172 3306 72394 An antibiotic. SGTC_387 norethindrone acetate 66.7 µM -0.43782681181658 0.321475704108902 no 2294 0.330755916667617 3196 541197 SGTC_3161 9100388 49.47 µM -0.438924563375713 0.321068445633498 no 2295 0.330358098858582 3190 25236368 SGTC_2196 6573537 42.6665 µM -0.440636497754148 0.320433758925642 no 2296 0.329738087910313 3307 2903087 SGTC_424 splitomicin 100 mM -0.440649685586485 0.320428871671377 no 2297 0.329733313488351 3223 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1076 itraconazole 331 nM -0.442072756128569 0.319901681735763 no 2298 0.329218279083037 3246 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2108 5365811 200 µM -0.442618576917143 0.319699573663209 no 2299 0.329020822780225 3267 780283 SGTC_1157 4092-0394 27.6 µM -0.443175129314213 0.319493546974601 no 2300 0.328819533321331 3366 3659885 SGTC_3189 9110682 49.47 µM -0.443371545533137 0.319420850165333 no 2301 0.328748506908948 3275 17122418 SGTC_2465 5809242 33.21 µM -0.44416893343952 0.319125795349213 no 2302 0.328460225619971 3218 2731748 SGTC_544 k015-0020 52.4 µM -0.444901607645386 0.318854787299713 no 2303 0.328195430397521 3227 3008304 SGTC_3038 9091290 49.47 µM -0.446104730665067 0.318409975556383 no 2304 0.327760797894631 3335 25236843 SGTC_2677 mitomycin C 100 µM -0.446288571858723 0.318342029873832 no 2305 0.327694405132475 3230 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1915 st067105 30.6 µM -0.446373646685253 0.318310589221957 no 2306 0.327663682889524 3267 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1833 st055984 71 µM -0.448150799746545 0.31765411570273 no 2307 0.327022183923353 3201 676288 SGTC_1073 triclabendazole 3.09 µM -0.448239903089253 0.317621216335504 no 2308 0.32699003371986 3283 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2950 9072895 21.46 µM -0.44868154273539 0.317458172281312 no 2309 0.326830700581581 3293 17332245 SGTC_845 0330-0138 4.51 µM -0.448824410071538 0.317405436248636 no 2310 0.326779164182845 3248 9039800 SGTC_1776 st049249 45.9 µM -0.452663578146596 0.315989690736661 no 2311 0.325395504961768 3251 1822314 SGTC_1218 1348-1416 30.7 µM -0.455147983693239 0.31507496679646 no 2312 0.324501389671492 3209 6787668 SGTC_477 mead ethanolamide 10 µM -0.458017391420608 0.314019900166392 no 2313 0.323469973314357 3222 16061185 SGTC_2652 actinonin 100 µM -0.459180425347492 0.313592690442172 no 2314 0.323052303055476 3192 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_808 0711-0032 135 µM -0.459272449431263 0.313558898492227 no 2315 0.323019264760944 3283 4252555 SGTC_1781 st038725 66.3 µM -0.459346612633826 0.313531666333471 no 2316 0.322992639858797 3186 4270275 YIL048W NEO1 SGTC_1815 st051655 58.2 µM -0.459403907731511 0.313510628709197 no 2317 0.322972071298379 3292 5984156 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.459793699399266 0.313367521039114 no 2318 0.322832153045671 3326 756377 SGTC_1333 1482-0047 286 µM -0.461667958149844 0.312679800444018 no 2319 0.32215972612971 3325 3811116 SGTC_457 grayanotoxin iii 135 µM -0.461993644764963 0.312560362845556 no 2320 0.322042938957846 3302 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_532 1548-0774 215 µM -0.464387573984251 0.311683052613502 no 2321 0.321185045575527 3429 5932993 SGTC_565 1418-0001 44.5 µM -0.46465535312418 0.311584985120965 no 2322 0.321089142897624 3358 2862145 SGTC_816 0325-0417 81.3 µM -0.465088720114399 0.311426303486186 no 2323 0.320933961711504 3294 68101 SGTC_180 1486-1293 102.781 µM -0.46529300792401 0.311351513617508 no 2324 0.32086082064265 3388 4140536 SGTC_509 pifithrin 175 µM -0.465826517245156 0.311156232311582 no 2325 0.320669841341063 3339 4817 A p53 inhibitor. SGTC_1811 st050069 61.5 µM -0.468069412166066 0.310335843612808 no 2326 0.3198674762036 3320 3877702 SGTC_1994 st072947 40.9 µM -0.468077056169482 0.310333049258385 no 2327 0.319864743103142 3329 5286565 YDL195W SEC31 SGTC_299 1273-0059 1.44 µM -0.470382052047087 0.309490931210692 no 2328 0.319041042371727 3297 2848077 SGTC_3070 9117005 49.47 µM -0.470784074229205 0.309344156762423 no 2329 0.318897469242262 3330 8779016 SGTC_1173 0443-0020 122 µM -0.470947425748384 0.309284527375752 no 2330 0.31883913970388 3224 5331295 SGTC_217 ketoconazole 989 nM -0.472821572984203 0.308600753550655 no 2331 0.318170240829021 3296 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_3156 9099931 49.47 µM -0.473101414033755 0.308498711704643 no 2332 0.31807041400361 3189 18111053 SGTC_2796 7949634 45.45 µM -0.473547662078994 0.308336021450805 no 2333 0.317911252671705 3227 2971588 SGTC_729 4092-0585 94.1 µM -0.473989220810048 0.308175077840756 no 2334 0.317753796958959 3205 2169061 SGTC_3356 9151811 4.48 µM -0.474244678180546 0.308081983095504 no 2335 0.317662718295007 3200 1859254 YPR165W RHO1 SGTC_2310 7668677 200 µM -0.474940300172746 0.307828544485666 no 2336 0.31741476290923 3420 2197143 SGTC_1024 4507-0395 26 µM -0.476080426631182 0.307413356118748 no 2337 0.317008540491826 3381 4201836 SGTC_2033 5192550 145 µM -0.476199809055464 0.307369896080686 no 2338 0.316966017762092 3240 182073 SGTC_2943 9068529 45.32 µM -0.47691283571402 0.307110381828289 no 2339 0.316712095720964 3321 3270634 SGTC_352 k048-0007 5.11 µM -0.482293602531599 0.305155111805805 no 2340 0.314798695634998 3336 6811911 SGTC_2699 st077704 54.6 µM -0.483167979931115 0.304837902002197 no 2341 0.314488234407113 3314 645852 SGTC_259 usnic acid 108.925 µM -0.483713622994691 0.304640025919852 no 2342 0.31429456183021 3422 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1232 0279-0259 161 µM -0.484226438649159 0.304454106705779 no 2343 0.314112587725415 3278 1560000 SGTC_1309 pyrazolanthrone 13.4 µM -0.48497089443789 0.30418429721577 no 2344 0.313848495869463 3343 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.485161920969322 0.304115081576782 no 2345 0.313780745556298 3270 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1896 st058441 89 µM -0.4852483751328 0.304083758496151 no 2346 0.31375008540463 3264 688759 SGTC_110 0850-0284 111.64 µM -0.489525533805094 0.302535906442963 no 2347 0.312234840935895 3195 3906265 SGTC_3066 9117245 49.47 µM -0.491206711398687 0.301928476996324 no 2348 0.31164012630077 3270 17176980 SGTC_236 1509-0011 5.31 µM -0.491609131384976 0.301783159186581 no 2349 0.311497843465491 3432 3107280 SGTC_2118 5526350 200 µM -0.494482860225568 0.300746342701932 no 2350 0.310482604048559 3331 743594 SGTC_2122 5258151 111.688 µM -0.494611755719302 0.300699876009125 no 2351 0.310437101201519 3276 2173356 SGTC_1925 st057770 10.1 µM -0.495907516373508 0.300232935749178 no 2352 0.309979831423823 3254 5989122 SGTC_1762 st045503 25.4615 µM -0.496133491387664 0.300151536981279 no 2353 0.309900115630055 3339 4645554 SGTC_3120 9124077 49.47 µM -0.497106431047683 0.299801187102886 no 2354 0.30955699989507 3364 18774327 YGL155W CDC43 SGTC_179 1273-0063 6.77 µM -0.497988254051746 0.299483807863504 no 2355 0.309246160574802 3249 3108139 SGTC_1352 1496-0991 99 µM -0.499391276209705 0.298979156673494 no 2356 0.308751881870178 3293 3000039 SGTC_3143 9086658 49.47 µM -0.500459349394152 0.298595241944412 no 2357 0.30837583630731 3328 25236626 SGTC_474 dl-dihydrosphingosine 5 µM -0.501473201888027 0.298231024189543 no 2358 0.308019066586442 3406 3058739 A sphingolipid protein kinase C inhibitor. SGTC_223 busulfan 5 mM -0.502263351680955 0.29794731005571 no 2359 0.307741142473193 3355 2478 A DNA alkylator. SGTC_1361 1608-0041 5.61 µM -0.502749513391338 0.297772808180825 no 2360 0.307570196696983 3313 X1361 SGTC_1574 spiramycin 23.7 µM -0.503027603647229 0.297673012006665 no 2361 0.30747243246972 3293 6419898 An antibiotic and protein synthesis inhibitor. SGTC_149 3970-0822 46.1 µM -0.504939352070407 0.296987370601821 no 2362 0.306800716768508 3418 3114250 YBL034C STU1 SGTC_803 4488-1585 147 µM -0.507082760499467 0.296219505402951 no 2363 0.306048375305018 3373 747204 SGTC_3186 9110464 49.47 µM -0.507798296000582 0.295963371338079 no 2364 0.30579740246628 3412 17018021 SGTC_980 1473-0395 201 µM -0.508098658921321 0.29585588332592 no 2365 0.305692077855184 3277 768876 SGTC_2258 7960471 200 µM -0.508312224505239 0.295779467556636 no 2366 0.3056171991867 3325 2974708 SGTC_351 caspofungin 25 nM -0.50887278629706 0.295578936438092 no 2367 0.305420698137771 3316 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3243 9134147 49.47 µM -0.512699062106917 0.294211826116568 no 2368 0.304080922932703 3392 24282180 SGTC_1658 st012944 20 µM -0.514352566835102 0.293621941993392 no 2369 0.303502757875633 3363 24207260 SGTC_17 0960-0276 49.807 µM -0.514935729691376 0.293414030627246 no 2370 0.303298966124257 3342 6821114 SGTC_826 1683-5028 118 µM -0.515969547689186 0.293045617762422 no 2371 0.302937839107034 3377 722377 SGTC_1109 tnp00067 928.257 nM -0.517695794469512 0.292430928758235 no 2372 0.302335266474245 3350 676295 SGTC_516 3992-2719 87.3 µM -0.518199354125645 0.292251732173806 no 2373 0.302159592685493 3220 5350887 YDR037W KRS1 SGTC_66 0109-0187 42.4 µM -0.51823454695936 0.292239210372759 no 2374 0.302147316889269 3427 759417 SGTC_1506 4226-2149 212 µM -0.518987897410691 0.291971224072797 no 2375 0.301884590492038 3384 991114 SGTC_2185 6113692 200 µM -0.519070470820576 0.291941857528499 no 2376 0.301855799759914 3403 874150 SGTC_2334 9017922 200 µM -0.519096822170345 0.291932486180334 no 2377 0.301846612138781 3371 3163164 SGTC_2234 tolnaftate 200 µM -0.519129428431231 0.291920890587861 no 2378 0.301835243863909 3337 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1031 k035-0009 16 µM -0.519763387713537 0.291695481634504 no 2379 0.30161425022939 3432 5180959 SGTC_2013 4024628 200 µM -0.519769128234037 0.291693440920263 no 2380 0.30161224945786 3431 5230760 SGTC_1234 0326-0494 15.5 µM -0.520312573134481 0.291500280260479 no 2381 0.301422867003789 3451 1547813 SGTC_224 benfluorex 43.875 µM -0.521507073560426 0.291075919906938 no 2382 0.301006789635347 3421 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_76 0433-0009 400.328 µM -0.521582580338123 0.291049104933642 no 2383 0.300980497249482 3375 2841569 SGTC_1327 1436-0082 2.18 µM -0.522737744211194 0.290639011687045 no 2384 0.30057838418534 3322 15992205 SGTC_286 k060-0067 22.9 µM -0.523151889101834 0.290492052494104 no 2385 0.30043427925589 3336 5985051 SGTC_2041 5107442 45.335 µM -0.524147912127608 0.29013875649343 no 2386 0.300087833172458 3456 793005 SGTC_1008 4106-0037 6 µM -0.524205073790852 0.290118486981516 no 2387 0.300067956149896 3387 2905394 SGTC_3233 9132340 49.47 µM -0.524614465194555 0.289973336288993 no 2388 0.299925614474204 3320 17682950 SGTC_3279 9140807 49.47 µM -0.524757975390754 0.289922462470071 no 2389 0.299875724516323 3386 45595718 SGTC_446 go6976 132 µM -0.524835648587388 0.289894929363067 no 2390 0.299848723733532 3401 3501 A protein kinase C inhibitor. SGTC_657 3534-0529 86.7 µM -0.525271421697541 0.289740481991589 no 2391 0.299697260551576 3409 1049549 SGTC_2340 7987427 183.45 µM -0.525393748471367 0.289697133691259 no 2392 0.299654749238017 3389 2239331 SGTC_2781 5567276 71.43 µM -0.526035174480288 0.289469884742377 no 2393 0.299431883962426 3434 2853274 SGTC_103 0844-0104 51.839 µM -0.526074729019495 0.289455873821313 no 2394 0.29941814308671 3440 5375804 SGTC_1339 1486-1321 22.7 µM -0.526569400079309 0.289280679444081 no 2395 0.299246323155361 3337 3469382 SGTC_588 3970-1144 52.9 µM -0.527485138907468 0.288956489868918 no 2396 0.298928366912551 3388 1888707 SGTC_839 0122-0028 230 µM -0.528197900188242 0.288704276708267 no 2397 0.298680993330623 3316 759448 SGTC_935 2996-0153 430 µM -0.528534533108397 0.288585193984539 no 2398 0.298564192624854 3438 23738523 SGTC_2168 5727979 200 µM -0.530256238700356 0.287976508742883 no 2399 0.29796714174103 3365 695210 SGTC_2486 5283202 22.39 µM -0.531073771267228 0.287687693771475 no 2400 0.297683829529028 3335 1377751 SGTC_887 0885-0007 9.62 µM -0.534314019426822 0.286544338979745 no 2401 0.296562147152967 3430 5719458 SGTC_3049 9092223 49.47 µM -0.534841381207858 0.286358458131708 no 2402 0.296379772773519 3396 8623917 SGTC_2215 7188065 200 µM -0.535291244767585 0.286199938575955 no 2403 0.296224239790696 3435 940217 SGTC_2533 agelasine 13.65 µM -0.536088096627465 0.28591925221718 no 2404 0.295948833197725 3499 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1015 4130-4525 82 µM -0.537072635360801 0.285572635103864 no 2405 0.295608721041688 3308 1363237 SGTC_1697 st025554 27.742 µM -0.537301872458076 0.285491958509913 no 2406 0.295529556125791 3386 1269519 SGTC_1610 st001799 48.1 µM -0.537609210339211 0.285383812532889 no 2407 0.295423435124265 3292 621897 SGTC_888 0916-0002 6.97 µM -0.538554258520552 0.285051391504241 no 2408 0.295097228376602 3475 2802138 YIL048W NEO1 SGTC_213 1246-0773 967 nM -0.539772773384636 0.284623051146581 no 2409 0.294676872849582 3375 6251622 SGTC_375 3970-0961 9.27 µM -0.539800043787778 0.2846134683921 no 2410 0.29466746843925 3356 2898222 SGTC_1852 st056254 31.4 µM -0.54046462245242 0.284379984673306 no 2411 0.294438326132371 3313 442583 SGTC_2366 9070441 60.58 µM -0.540657303595141 0.284312307910365 no 2412 0.294371906339282 3346 6837235 SGTC_1973 st070275 50.2 µM -0.540874471846364 0.284236039595524 no 2413 0.294297053802854 3384 17118334 SGTC_386 1509-0011 3.07 µM -0.541048688004763 0.284174862894865 no 2414 0.294237012148037 3417 3107280 SGTC_1526 st051518 75 µM -0.543350730379686 0.283367083358082 no 2415 0.293444170871777 3324 673993 SGTC_603 3794-0023 45.9 µM -0.544725683294378 0.282885142368702 no 2416 0.292971098968774 3428 3802260 SGTC_1354 1498-1681 81 µM -0.545158597756021 0.282733481076306 no 2417 0.292822221940236 3432 5754243 SGTC_1275 0867-0008 21.1 µM -0.546233838619652 0.28235696510115 no 2418 0.29245260424093 3322 3422836 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.546244088359588 0.282353377121316 no 2419 0.292449081901791 3443 279621 SGTC_1923 st058458 19.1 µM -0.546369481791053 0.282309484212192 no 2420 0.292405991849688 3498 3534982 SGTC_3013 9080133 71.4286 µM -0.546822634574432 0.282150889292524 no 2421 0.292250295571602 3521 17050193 SGTC_2570 licareol 100 µM -0.54690566941192 0.282121833317172 no 2422 0.292221770268694 3376 443158 SGTC_759 3486-0358 89.3 µM -0.547975071902123 0.281747751330223 no 2423 0.291854509805678 3486 875103 SGTC_1518 st038567 90.8 µM -0.548279151945831 0.281641426386265 no 2424 0.291750120131198 3436 77966 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.549125660939917 0.281345537117131 no 2425 0.291459608066261 3346 88881 An O-methylated flavonoid and antioxidant. SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.550696366726197 0.280796909486668 no 2426 0.290920917845431 3439 140250 A respiratory chain inhibitor. SGTC_1326 1431-2094 10.8 µM -0.55108287523191 0.280661986315499 no 2427 0.290788432021565 3359 616278 SGTC_1651 st011928 86.1 µM -0.551582562392086 0.280487601006447 no 2428 0.290617193097322 3460 720198 SGTC_3015 9080845 49.47 µM -0.552384036095314 0.280208005092264 no 2429 0.290342632819295 3467 5296973 SGTC_1944 st076371 56.9 µM -0.553283392410052 0.279894423465386 no 2430 0.290034685666264 3322 24208455 SGTC_2922 7999257 32.47 µM -0.554974359123781 0.279305289573222 no 2431 0.289456099407533 3460 2988377 SGTC_3077 9117319 49.47 µM -0.555004283425229 0.279294869355403 no 2432 0.289445865302216 3449 17154678 SGTC_910 3454-3003 490 µM -0.55568503670851 0.279057869000432 no 2433 0.289213093737831 3457 820824 SGTC_1063 disulfiram 1.84 µM -0.555760617094616 0.279031562155013 no 2434 0.289187255787791 3422 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3024 9090631 49.47 µM -0.556224952786981 0.27886996987925 no 2435 0.28902854156602 3433 25236383 SGTC_1412 3909-8563 178 µM -0.557058724268085 0.278579925540781 no 2436 0.288743653674456 3508 23767530 SGTC_1081 sertraline 6 µM -0.557701537280435 0.278356410331337 no 2437 0.288524103887481 3464 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3163 9099914 49.47 µM -0.557907204085263 0.278284915524744 no 2438 0.288453875963137 3456 16268368 SGTC_1747 st037496 66.6 µM -0.558803124084086 0.277973576321188 no 2439 0.288148045067333 3391 723305 SGTC_3272 9137413 49.47 µM -0.558929914509583 0.27792952939072 no 2440 0.288104776298375 3420 17614870 SGTC_2568 diosmetin 100 µM -0.559172202684764 0.277845368075314 no 2441 0.288022101051388 3498 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1760 st045453 10.4495 µM -0.559673152130376 0.277671397545582 no 2442 0.287851199138576 3464 3323419 YIL048W NEO1 SGTC_2621 lithochol-11-enic acid 100 µM -0.56019250489463 0.277491092077126 no 2443 0.287674069404487 3481 6708711 SGTC_1689 st020265 53.493 µM -0.560195170842647 0.277490166678516 no 2444 0.287673160292849 3475 5758320 YPR016C TIF6 SGTC_1509 1326-1131 80 µM -0.561181359549331 0.277147946321401 no 2445 0.287336954484926 3438 768313 SGTC_435 c-PAF 6.7 µM -0.56241883136075 0.276718819793801 no 2446 0.286915345855611 3411 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_421 streptovitacin 30 mM -0.562841760019786 0.276572232623656 no 2447 0.286771320617777 3484 91467 include heat shock SGTC_1656 st012921 11 µM -0.563229097713603 0.276438014693187 no 2448 0.286639445694582 3419 6732821 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.564063857692372 0.276148867324394 no 2449 0.28635533696827 3453 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2289 7946404 165.07 µM -0.564181272743077 0.276108208560316 no 2450 0.286315385739417 3428 1246120 YPR165W RHO1 SGTC_2087 5276107 200 µM -0.565406195202037 0.27568421482689 no 2451 0.28589875585288 3448 144405 SGTC_2882 9058044 58.44 µM -0.56611260945161 0.275439842732933 no 2452 0.285658616012193 3425 18076804 SGTC_923 1900-2434 73.3 µM -0.568255926612908 0.274699051136071 no 2453 0.284930600523773 3446 5910570 SGTC_443 clozapine 122 µM -0.568550073520464 0.274597462288716 no 2454 0.28483075743841 3419 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1700 st030840 7.9285 µM -0.569483628194381 0.274275165434321 no 2455 0.284513989045863 3466 5499307 SGTC_46 0329-0187a 2.197 µM -0.570100383554434 0.274062341679948 no 2456 0.284304807516341 3439 46494817 SGTC_579 4491-1009 110 µM -0.570245011383096 0.274012446772677 no 2457 0.284255765531847 3570 1271041 SGTC_2131 toluylene red 5.2905 µM -0.571150011439916 0.273700334320202 no 2458 0.283948980087318 3401 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_420 mitomycin C 81.9 mM -0.571573885963986 0.273554210830541 no 2459 0.283805345612781 3432 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3061 glucosamine 200 µM -0.572109248920408 0.273369708805325 no 2460 0.283623981803542 3434 91431 and experimental redox chemotherapeutic SGTC_2179 6298986 200 µM -0.572158599315623 0.273352704291295 no 2461 0.283607266266856 3468 738374 SGTC_2923 7992654 58.14 µM -0.574033422247846 0.272707090528045 no 2462 0.282972592351767 3438 2985126 SGTC_1657 st012939 43.4 µM -0.574388649122487 0.272584849970152 no 2463 0.282852416154628 3502 24207257 SGTC_3184 9108758 49.47 µM -0.574581887170361 0.272518364380049 no 2464 0.282787052416511 3464 902885 SGTC_2754 granisetron 64.02 µM -0.575555081226867 0.272183649127161 no 2465 0.282457974989561 3512 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_3212 9128307 49.47 µM -0.576266805372999 0.271938991890864 no 2466 0.282217428073785 3282 27243542 SGTC_1058 3448-5425 97.3 µM -0.578018320367829 0.271337369766056 no 2467 0.281625875230997 3450 7279705 SGTC_1469 k284-2957 126 µM -0.578370586487314 0.271216451200552 no 2468 0.281506973904317 3457 23884841 SGTC_1982 st072467 71.9 µM -0.580261304498669 0.270567904355743 no 2469 0.280869208939619 3364 3163533 SGTC_2250 alverine citrate 130 µM -0.58069174792214 0.270420363637231 no 2470 0.280724112175637 3443 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1922 5578187 25 µM -0.580884228567712 0.270354401120136 no 2471 0.280659241237539 3549 1350412 SGTC_5 0352-0601 109.883 µM -0.581570092299853 0.270119423166387 no 2472 0.280428146460959 3431 762456 SGTC_1237 0330-0133 46.1 µM -0.582116276303876 0.269932372799219 no 2473 0.280244181256101 3447 X1237 YHR072W ERG7 SGTC_2705 st078069 42.8 µM -0.582272550572637 0.269878865844255 no 2474 0.28019155585598 3447 1530061 SGTC_96 0929-0093 37.281 µM -0.582274748176301 0.26987811344167 no 2475 0.280190815846522 3416 6991579 SGTC_1252 0493-0875 34.8 µM -0.584152463509078 0.269235616352887 no 2476 0.279558870203151 3452 3960963 SGTC_2323 6148992 148.28 µM -0.584291561840074 0.269188051674268 no 2477 0.279512084162278 3405 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_99 0109-0120 622.8 µM -0.584305748706023 0.269183200711924 no 2478 0.279507312591229 3546 759414 SGTC_3330 9141424 71.43 µM -0.586560307928244 0.268412849474774 no 2479 0.278749523443113 3493 27261020 SGTC_2838 9002687 71.43 µM -0.587818128149762 0.26798355225615 no 2480 0.278327187380681 3446 6457060 SGTC_1258 0671-0043 57.1 µM -0.588127589985625 0.267877985167473 no 2481 0.278223327758753 3461 4298767 SGTC_1733 st037357 54.9 µM -0.588352468466937 0.267801285243517 no 2482 0.278147867324242 3454 1272339 YGL099W LSG1 SGTC_1744 st037937 38.9 µM -0.588634736012698 0.267705027135107 no 2483 0.278053163491704 3531 1016152 SGTC_3138 9097216 49.47 µM -0.589356183122282 0.267459080469756 no 2484 0.277811181648255 3521 25237486 SGTC_355 1311-2252 105 µM -0.589952492487606 0.267255880245019 no 2485 0.277611250121876 3438 5338538 SGTC_2798 7813637 45.45 µM -0.591608520068173 0.266691976062732 no 2486 0.277056383602691 3508 956368 SGTC_895 0964-0006 13.7 µM -0.59169186474617 0.266663611756505 no 2487 0.277028472592334 3508 6738897 SGTC_1351 1496-0003 46.5 µM -0.592152975193752 0.266506711749473 no 2488 0.276874077788621 3513 3891978 SGTC_1032 k061-1018 98.7 µM -0.592378026130568 0.266430151624555 no 2489 0.276798738706712 3587 4005393 SGTC_3187 9109394 49.47 µM -0.594882304526056 0.265578972099178 no 2490 0.275961073239208 3444 17098090 SGTC_560 2332-1943 155 µM -0.596456924609064 0.265044481421128 no 2491 0.275435010984702 3516 21177716 SGTC_2755 lomerizine 42.69 µM -0.596637858166856 0.264983100168853 no 2492 0.275374594804653 3482 3949 A calcium channel blocker. SGTC_940 3232-1287 54.8 µM -0.598390840964436 0.264388779414706 no 2493 0.274789587837256 3503 1585493 YIL048W NEO1 SGTC_1167 k781-0610 148 µM -0.600323782036283 0.263734234178227 no 2494 0.274145236090877 3511 4525169 SGTC_1653 st012112 65 µM -0.600761150879322 0.26358624420227 no 2495 0.273999541482406 3542 720429 SGTC_1701 st028638 40.4 µM -0.601267011748451 0.263415131834238 no 2496 0.273831078815088 3525 3490878 SGTC_771 0250-0039 27.3 µM -0.602926008273886 0.26285435831616 no 2497 0.273278956566924 3440 3005115 SGTC_752 1896-0090 130 µM -0.603037628881973 0.262816650281164 no 2498 0.273241828484466 3525 772567 SGTC_3019 9081971 49.47 µM -0.603714109258484 0.262588178696042 no 2499 0.273016865995005 3566 16451803 SGTC_493 zm226600 134 µM -0.603961408597767 0.262504682254215 no 2500 0.272934649911301 3563 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2485 5633444 17.78 µM -0.604594565134081 0.262290969610541 no 2501 0.272724209359747 3494 5724239 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.605238188533661 0.262073815410321 no 2502 0.272510372515076 3501 688761 SGTC_2377 9073351 62.6 µM -0.605620718407794 0.261944796079515 no 2503 0.272383320597353 3454 7337946 YHR072W ERG7 SGTC_2484 5809818 12.04 µM -0.605838142687389 0.261871477933422 no 2504 0.272311119297867 3505 2870548 SGTC_2002 4023503 131 µM -0.606924367555309 0.261505347219334 no 2505 0.271950552993851 3610 4736863 YCR052W RSC6 SGTC_3000 9075062 71.4286 µM -0.608001899853406 0.26114240632657 no 2506 0.271593106921772 3471 17057871 SGTC_2361 9034121 116 µM -0.608006890446809 0.261140725967467 no 2507 0.271591451953867 3485 6496917 SGTC_2759 disulfiram 3.38 µM -0.609102672897871 0.260771904855705 no 2508 0.271228193008383 3486 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_316 k060-0003 58.6 µM -0.609296088858005 0.260706832282937 no 2509 0.271164099529417 3561 6152314 SGTC_1201 1889-3372 45.9 µM -0.611138916715658 0.260087253438392 no 2510 0.270553808935256 3474 5392199 SGTC_2075 5212009 200 µM -0.611275497759159 0.260041363635221 no 2511 0.270508604622152 3495 780898 SGTC_3290 9121031 71.43 µM -0.611546849694944 0.259950204609033 no 2512 0.270418806300294 3464 17014854 SGTC_497 capsazepine 133 µM -0.611812365090731 0.259861022289314 no 2513 0.270330953883843 3472 2733484 A calcium channel blocker. SGTC_1445 4239-0156 97.7 µM -0.612136312986715 0.259752234820564 no 2514 0.270223786938411 3588 4008346 SGTC_2106 5357045 167.29 µM -0.612809655455332 0.259526189655208 no 2515 0.270001102889526 3509 668842 SGTC_566 0958-0068 16.5 µM -0.612861988105436 0.259508625521297 no 2516 0.26998379957532 3550 6815365 SGTC_445 e6 berbamine 66 µM -0.612917806641184 0.259489892114396 no 2517 0.269965344296404 3544 6610268 A calcium/calmodulin antagonist. SGTC_1353 1498-1206 8.11 µM -0.614798182333386 0.258859222541358 no 2518 0.269344004922534 3581 6756808 SGTC_1288 0973-0013 65.5 µM -0.615542757075132 0.258609714884359 no 2519 0.269098170719331 3553 4315430 SGTC_1561 5-methoxyflavone 52.9 µM -0.61582233499925 0.258516060240757 no 2520 0.269005892326398 3520 94525 SGTC_447 ml7 120 µM -0.617241605638897 0.25804089576002 no 2521 0.268537688389247 3566 4216 Selective myosin light chain kinase inhibitor. SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.617306666832584 0.25801912447162 no 2522 0.268516235141256 3563 1273210 SGTC_528 3492-0019 172 µM -0.617527013333911 0.257945397470043 no 2523 0.268443584588265 3567 2869262 SGTC_3127 9126946 49.47 µM -0.618655968540021 0.257567825380535 no 2524 0.268071511326157 3466 27243249 SGTC_2229 7354935 190 µM -0.620289220884517 0.257022102658459 no 2525 0.2675336951296 3511 318112 SGTC_991 3996-0057 64.7 µM -0.620836807684791 0.256839270821606 no 2526 0.267353501278816 3532 715343 SGTC_496 calpeptin 138 µM -0.623011613633619 0.256113801298783 no 2527 0.266638445033299 3514 73364 A calpain inhibitor. SGTC_1290 0986-0249 10.2 µM -0.623638644807214 0.255904835543805 no 2528 0.266432462658383 3522 53329 SGTC_1913 st060213 96.1 µM -0.624160218482572 0.25573108259063 no 2529 0.266261184866938 3586 688959 SGTC_22 0964-0034 14.468 µM -0.626348016906892 0.255002928230637 no 2530 0.265543348945719 3536 138402 SGTC_2592 piperlongumine 83.33 µM -0.627862062758063 0.254499651508193 no 2531 0.265047152572719 3501 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_289 k017-0060 526 µM -0.63067769114002 0.25356510761779 no 2532 0.264125644331632 3532 5512909 SGTC_442 cape 100 µM -0.633843902734962 0.252516358057232 no 2533 0.263091349211709 3547 5281787 SGTC_503 tyrphostin 8 294 µM -0.634259802496734 0.252378768906546 no 2534 0.262955642658097 3560 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_321 4534-3890 65.3 µM -0.636308860731488 0.251701470951681 no 2535 0.262287565388194 3572 699746 SGTC_426 0988-0037 14.6 µM -0.637633793099646 0.251264037908404 no 2536 0.261856046241524 3604 5383008 SGTC_1782 st039423 80.636 µM -0.642170749261913 0.249769189367639 no 2537 0.260381161507442 3514 2068169 SGTC_545 4218-0007 221 µM -0.642288110868172 0.249730583503167 no 2538 0.260343066167388 3558 2840508 SGTC_1728 st035614 33.7865 µM -0.642384619112548 0.249698839684537 no 2539 0.260311741937925 3533 15945546 SGTC_618 k072-0232 33.2 µM -0.644239190997135 0.249089244106195 no 2540 0.259710170413992 3560 5872756 YGL099W LSG1 SGTC_905 2-aminofluorene 215 µM -0.645452944279704 0.248690713879716 no 2541 0.259316851436765 3626 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2424 5537928 59.2 µM -0.645838254502023 0.248564270114425 no 2542 0.259192055346772 3610 5382802 SGTC_2481 5478948 45.16 µM -0.646163954854115 0.248457414698055 no 2543 0.259086590199164 3603 77792 SGTC_1271 0832-2808 169 µM -0.647111641516674 0.248146637983936 no 2544 0.258779845701196 3615 3663794 SGTC_932 2857-0803 154 µM -0.647141656396107 0.248136798535113 no 2545 0.258770133642707 3658 674898 SGTC_1729 st035615 45.989 µM -0.648264843554511 0.247768746049957 no 2546 0.258406834243168 3523 17385451 SGTC_182 3448-4371 550.524 µM -0.648601405595857 0.247658516231402 no 2547 0.258298023376148 3614 3491403 SGTC_1426 4048-4480 71.7 µM -0.648624119879505 0.247651077859037 no 2548 0.258290680679463 3592 14224343 SGTC_685 1278-0033 54.9 µM -0.64895813447608 0.24754171002754 no 2549 0.258182718476307 3641 3590572 SGTC_1360 1598-0022 39.8 µM -0.649169427422217 0.247472538799226 no 2550 0.258114435184256 3613 761525 SGTC_1519 esterone 74 µM -0.649704484166668 0.247297422826638 no 2551 0.257941563417714 3554 698 A steroid. SGTC_527 4476-4215 268 µM -0.650309752029 0.247099407703361 no 2552 0.257746079534173 3554 4418754 SGTC_990 3985-0011 41.3 µM -0.651192316988536 0.246810826101215 no 2553 0.257461174649019 3563 5399565 YGL099W LSG1 SGTC_1964 st076914 61 µM -0.651217853612597 0.246802478807668 no 2554 0.257452933489151 3608 24208661 SGTC_2842 9000675 19.48 µM -0.651323531535345 0.246767936904013 no 2555 0.257418830647524 3553 2989072 SGTC_146 3448-8650 53.125 µM -0.651448948606702 0.24672694641783 no 2556 0.257378360920906 3605 2891488 YIL048W NEO1 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.651590675955279 0.246680629576791 no 2557 0.257332632154356 3590 115019 SGTC_2734 clemastine 41.6 µM -0.652519598716915 0.246377170675214 no 2558 0.257033016923091 3563 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1629 st005085 44.9 µM -0.653709378387391 0.245988787921175 no 2559 0.256649529976178 3592 24207091 SGTC_370 0180-0345 38.7 µM -0.653835655898816 0.245947586128301 no 2560 0.256608846005622 3542 3989527 SGTC_1716 st033144 30.6155 µM -0.65409821412336 0.245861930556313 no 2561 0.25652426599528 3618 674617 SGTC_1235 benzylparaben 21.5 µM -0.655122612899076 0.245527889407996 no 2562 0.256194407023699 3588 7180 SGTC_1174 0739-0097 51.1 µM -0.655143956061304 0.245520932315189 no 2563 0.256187536824683 3612 728447 SGTC_1649 st011737 51.3 µM -0.656786712326104 0.244985771574705 no 2564 0.255659034659431 3572 1761035 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.657175381982388 0.244859246523048 no 2565 0.255534076471442 3637 165521 SGTC_921 1561-0023 372 µM -0.657901060700573 0.244623107842389 no 2566 0.255300854520799 3611 24050882 SGTC_3247 9135149 49.47 µM -0.658045059292439 0.244576264726802 no 2567 0.255254588827856 3585 8934436 YOR116C RPO31 SGTC_1042 0350-0096 82 µM -0.65954789946886 0.244087675373765 no 2568 0.254771999007019 3610 3122515 SGTC_1152 3909-8331 15.9 µM -0.660588792946493 0.2437495786277 no 2569 0.254438029040976 3597 16001939 SGTC_3104 9120930 49.47 µM -0.662151761811856 0.243242379668504 no 2570 0.253936982747953 3620 17014836 SGTC_2463 5473429 200 µM -0.662713817113048 0.243060126691336 no 2571 0.253756929414335 3556 5399405 SGTC_2054 5233173 129 µM -0.662757987715947 0.243045806989625 no 2572 0.253742782288198 3610 6889 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.662981051634753 0.242973498697168 no 2573 0.253671344867791 3585 17037758 SGTC_1010 4112-3296 15.2 µM -0.663505738136694 0.24280346246252 no 2574 0.253503352843299 3651 704384 SGTC_1458 k015-0034 6.33 µM -0.663852627554336 0.242691080667772 no 2575 0.253392319284946 3582 3598957 SGTC_2703 st077852 53.4 µM -0.664100213557172 0.242610887433856 no 2576 0.253313086740456 3612 6281836 SGTC_869 0564-0080 44.1 µM -0.664185133657807 0.242583385074576 no 2577 0.253285913585303 3585 6843321 SGTC_3315 9136395 68.55 µM -0.665597800178212 0.242126124381142 no 2578 0.252834106432527 3665 16876844 SGTC_2145 5634607 200 µM -0.665903268679357 0.242027309922438 no 2579 0.252736465553817 3596 308662 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.66665510103059 0.241784196668306 no 2580 0.252496232180544 3622 5379071 SGTC_941 3237-0776 460 µM -0.668392707847306 0.241222829852428 no 2581 0.251941474521317 3631 760008 SGTC_961 1252-1571 372 µM -0.670089185129629 0.240675434860129 no 2582 0.251400469331621 3631 6813498 SGTC_1054 3429-0080 167 µM -0.670630947849976 0.240500769164401 no 2583 0.251227831097818 3644 1162877 SGTC_246 cycloheximide 667 µM -0.670742038224823 0.240464961871864 no 2584 0.251192438760442 3520 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2571 chrysanthemic acid 100 µM -0.671251964334235 0.240300636794113 no 2585 0.251030014987084 3576 2743 An insecticide. SGTC_530 4358-1714 28 µM -0.671493333180152 0.240222876365378 no 2586 0.250953152565336 3639 1564641 SGTC_880 0833-0487 87.2 µM -0.672836422179206 0.239790431571024 no 2587 0.250525681724548 3612 76075 SGTC_98 0074-0023 107.663 µM -0.67407330461836 0.239392558899607 no 2588 0.250132355232219 3604 3563821 SGTC_1226 3909-7979 35.4 µM -0.674117470377794 0.239378358602285 no 2589 0.250118316655973 3644 6615510 SGTC_2788 5282734 71.43 µM -0.674536066318509 0.23924379332246 no 2590 0.249985282051254 3672 743706 SGTC_65 0798-0905 34.986 µM -0.675620212067628 0.238895467172377 no 2591 0.24964090269795 3749 3602145 SGTC_3167 9103034 49.47 µM -0.676526907066622 0.238604367431243 no 2592 0.249353084265555 3642 5127859 SGTC_1057 3448-5381 134 µM -0.676612405350395 0.238576927726104 no 2593 0.249325953061146 3659 5497911 SGTC_590 k048-0076 22.4 µM -0.677416895883593 0.238318820212556 no 2594 0.249070740637403 3638 6832814 SGTC_1496 4469-0713 57.4 µM -0.678099708155508 0.238099871209427 no 2595 0.248854237884683 3621 746691 SGTC_1579 chlormadinone acetate 49.4 µM -0.678813413985837 0.237871133831583 no 2596 0.248628046680496 3646 45114258 A steroidal progestin. SGTC_2314 7727897 200 µM -0.678937373642926 0.237831417974544 no 2597 0.248588771933868 3633 900724 SGTC_2078 5212016 200 µM -0.680439697872386 0.237350372422914 no 2598 0.248113046038851 3577 1899708 SGTC_156 3474-0145 5.642 µM -0.681414510304961 0.237038522652318 no 2599 0.24780462197686 3592 2265471 SGTC_2409 alverine citrate 63.97 µM -0.681564265570859 0.236990634786543 no 2600 0.247757258567587 3726 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1082 camptothecin 424.86 nM -0.682168969753392 0.236797320105851 no 2601 0.247566056693847 3592 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_281 1672-3440 14.9 µM -0.682255300974102 0.236769728410031 no 2602 0.247538765991522 3649 6833000 SGTC_2685 mycophenolic acid 18.85 µM -0.682526015865495 0.236683218651504 no 2603 0.247453199036803 3619 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1213 1315-0166 115 µM -0.682725569307643 0.236619460407751 no 2604 0.247390134754484 3618 768401 SGTC_1888 azatryptophan 97.5 µM -0.683652910342805 0.23632329469861 no 2605 0.247097182668051 3612 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2727 riluzole 51.77 µM -0.683676296975025 0.236315828329105 no 2606 0.247089797103135 3642 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2405 ticlatone 3.52 µM -0.684341576120735 0.236103487046255 no 2607 0.246879749525567 3571 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2506 ethyl hematommate 54.16 µM -0.686352389894868 0.235462322549662 no 2608 0.24624545974588 3645 3940691 An allergen. SGTC_944 3370-0224 231 µM -0.686975267985378 0.235263907838364 no 2609 0.246049156886111 3664 4580514 SGTC_3185 9108267 49.47 µM -0.6874486106967 0.235113188627758 no 2610 0.245900036936733 3624 4910486 SGTC_480 am 92016 50 µM -0.687730923315125 0.235023321575656 no 2611 0.2458111214213 3587 2129 K+ channel blocker. SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.687981860637122 0.234943457985527 no 2612 0.245732102174576 3631 2333 A French combination drug. SGTC_1129 3453-1384 223 µM -0.688149485233926 0.234890117951155 no 2613 0.245679325400063 3723 1084452 SGTC_1389 3405-0187 19 µM -0.688326539996951 0.234833784400423 no 2614 0.245623586138981 3608 799890 SGTC_2085 5307070 144.047 µM -0.688490371568306 0.234781664727957 no 2615 0.245572015770084 3620 2840351 SGTC_400 oxethazaine 37.5 µM -0.689662775058592 0.23440887515206 no 2616 0.245203140206669 3640 4621 A local anesthetic. SGTC_2676 harmalol 100 µM -0.690180789256049 0.23424426637293 no 2617 0.245040251354727 3659 5459187 A monoamine oxidase inhibitor SGTC_1029 k015-0030 64.7 µM -0.692460089694902 0.233520736444287 no 2618 0.244324220521951 3708 2208316 SGTC_962 1254-0300 21.5 µM -0.695187292631586 0.232656657712446 no 2619 0.243468967423678 3633 7340576 SGTC_1606 st000094 49.2 µM -0.696355412669018 0.232287098435716 no 2620 0.243103139349717 3687 1242210 SGTC_206 4546-0025 72.014 µM -0.696479743180729 0.232247783110972 no 2621 0.243064219430498 3681 6620745 YIL048W NEO1 SGTC_188 3229-0966 278.469 µM -0.696709573917894 0.232175116652967 no 2622 0.242992283021591 3741 5722370 SGTC_723 4182-0001 115 µM -0.696755007933179 0.232160753105718 no 2623 0.242978063659207 3640 744821 YLR208W SEC13 SGTC_610 4215-0184 155 µM -0.700672590606386 0.230924106727899 no 2624 0.241753682608651 3697 5605015 SGTC_1320 1313-0481 95.3 µM -0.700693699217307 0.230917453440898 no 2625 0.241747094514591 3692 6813365 YLR208W SEC13 SGTC_2363 9053361 176 µM -0.701047695785884 0.230805892139622 no 2626 0.241636625086189 3714 6469797 YMR079W SEC14 SGTC_1211 1056-0033 32.3 µM -0.701116802718765 0.2307841167421 no 2627 0.241615062528646 3683 6741922 SGTC_1356 1502-0781 85.8 µM -0.701368454617493 0.230704831644021 no 2628 0.24153655161585 3659 567702 SGTC_2326 6164455 177.58 µM -0.702517177447749 0.230343109947724 no 2629 0.241178346560679 3664 2888790 SGTC_2443 5493264 126.67 µM -0.702809222576005 0.230251198350574 no 2630 0.241087324489475 3693 5340055 SGTC_2836 9010338 19.48 µM -0.702828102631097 0.230245257180262 no 2631 0.241081440761859 3611 2994051 SGTC_143 4032-1194 15.74 µM -0.703181825032464 0.230133963768866 no 2632 0.240971222135777 3692 1806963 SGTC_1565 sinapyl alcohol 95.1 µM -0.70445443841012 0.229733804213335 no 2633 0.240574907157697 3668 5280507 A phenol propionate derived from cinnamic acid. SGTC_71 0417-1750 47.813 µM -0.70621417456498 0.229181116651036 no 2634 0.240027478403016 3653 6811472 SGTC_925 2064-1272 59.6 µM -0.706586241295253 0.229064355695456 no 2635 0.239911820808149 3683 6815817 SGTC_741 4582-0002 126 µM -0.709354798634971 0.228196583411767 no 2636 0.239052165223167 3669 2912688 SGTC_3191 9110352 49.47 µM -0.710004792597937 0.227993118542814 no 2637 0.238850582098233 3671 17122424 SGTC_144 4161-2749 112.381 µM -0.710251093191869 0.227916046774546 no 2638 0.23877422100356 3610 797501 YMR168C CEP3 SGTC_1103 duloxetine 36.1 µM -0.712653531481391 0.227165051003229 no 2639 0.238030088878703 3759 60835 A selective serotonin reuptake inhibitor. SGTC_229 benomyl 22.8748 µM -0.712794737263847 0.227120953897359 no 2640 0.237986391334797 3702 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1840 st055363 71 µM -0.712865843110953 0.227098750103444 no 2641 0.237964388583014 3675 676033 SGTC_2947 9072639 7.68 µM -0.713079315488033 0.227032097724424 no 2642 0.23789833911614 3696 16488146 SGTC_2837 9008476 45.46 µM -0.714154541848504 0.22669654805466 no 2643 0.237565811348273 3695 2992805 SGTC_2740 felodipine 17.08 µM -0.715682834496709 0.226220090362343 no 2644 0.237093606199235 3626 3333 L-type calcium channel blocker SGTC_1780 st038448 24.544 µM -0.716092067888335 0.22609260461798 no 2645 0.236967250659787 3744 728868 YDL195W SEC31 SGTC_392 N-ethylmaleimide 8.33 µM -0.716698856420159 0.225903650601496 no 2646 0.236779965836345 3676 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2799 7812892 81.82 µM -0.717110585112125 0.22577548910797 no 2647 0.236652932455678 3688 20205235 SGTC_1822 st052468 42 µM -0.717570356177038 0.22563242176719 no 2648 0.236511120564734 3708 2873678 SGTC_1702 st027038 51 µM -0.718286873639247 0.225409564735476 no 2649 0.236290211018011 3705 5521182 SGTC_2582 agaric acid 100 µM -0.719042907715518 0.225174552104211 no 2650 0.236057241343605 3609 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1827 berberine 7.24 µM -0.719076528700374 0.225164104270549 no 2651 0.236046884076088 3655 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2350 9023895 38.85 µM -0.71935769326545 0.225076742192013 no 2652 0.235960278432872 3720 2997209 SGTC_336 4111-0029 111 µM -0.722072536944046 0.224234187918116 no 2653 0.235124940933203 3656 3131175 SGTC_2411 st077133 39.94 µM -0.722827373715652 0.224000242206109 no 2654 0.234892973725447 3791 1403142 YNL221C POP1 SGTC_3301 9125354 19.7965 µM -0.7235377094358 0.223780215358355 no 2655 0.234674797596813 3690 41905162 SGTC_113 0099-0221 2.5 µM -0.723920319802163 0.22366175253107 no 2656 0.234557327151611 3716 89219 SGTC_2949 9072542 2.23 µM -0.72806795241599 0.222379863893142 no 2657 0.233285995237805 3775 16457352 SGTC_3092 9117248 49.47 µM -0.728469022128091 0.222256129835802 no 2658 0.233163262487874 3781 17141857 SGTC_1844 rapamycin 4 nM -0.728910109528661 0.222120095286384 no 2659 0.233028325182712 3674 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1035 k081-0041 55.2 µM -0.72954322532742 0.221924920874639 no 2660 0.23283471843375 3721 731709 SGTC_1976 st070609 63.5 µM -0.732625717313255 0.220976062874846 no 2661 0.231893370645577 3660 682556 SGTC_970 1315-0089 19.5 µM -0.735140325216503 0.220203734716187 no 2662 0.231127018819033 3694 6811083 YLR033W RSC58 SGTC_2970 9090938 41.86 µM -0.736632090506176 0.219746291482117 no 2663 0.230673057213724 3725 17217104 SGTC_1068 loratadine 26.9 µM -0.737033262867925 0.219623366898115 no 2664 0.230551060826452 3764 3957 A H1 histamine antagonist. SGTC_1871 st057448 67.3 µM -0.737800648418841 0.219388339735589 no 2665 0.230317799611137 3798 691747 SGTC_3003 9075612 71.4286 µM -0.737846413939001 0.219374327698248 no 2666 0.23030389249505 3740 6501993 SGTC_2875 9039966 71.43 µM -0.74067863350407 0.218508187701508 no 2667 0.229444158737061 3786 6463691 SGTC_2674 ligustilide 100 µM -0.742081402830075 0.218079927663588 no 2668 0.229019008367974 3742 5319022 A signalling regulator. SGTC_663 1486-0733 13.9 µM -0.743244207717786 0.217725294885745 no 2669 0.228666921548142 3762 722445 YPR165W RHO1 SGTC_1484 3473-2379 286 µM -0.743623617340475 0.21760965439062 no 2670 0.228552105542854 3847 671917 SGTC_2119 5528445 120.635 µM -0.747588348159902 0.216403363802641 no 2671 0.227354247498516 3764 791935 SGTC_3310 9130229 44.1445 µM -0.748808259595094 0.216032979271391 no 2672 0.226986390368357 3819 7761258 SGTC_563 tetrahydrosecaminediol 614 µM -0.749164255728274 0.215924962435275 no 2673 0.226879105123592 3798 334274 A psychoactive constituent of the cannabis plant. SGTC_3239 9133757 49.47 µM -0.751392184746767 0.215249672274501 no 2674 0.226208332368076 3749 17036923 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.755950885231873 0.213871746439374 no 2675 0.224839321749135 3783 6708739 YPR165W RHO1 SGTC_2072 5231554 129 µM -0.756225327310229 0.213788957026328 no 2676 0.224757054993559 3819 789545 SGTC_2807 7945238 51.95 µM -0.761998665481106 0.212051676852926 no 2677 0.223030400324548 3817 17148797 SGTC_1703 st026983 48.3 µM -0.762015333303982 0.212046673247409 no 2678 0.223025426374911 3776 1104023 SGTC_3028 9087778 49.47 µM -0.763475484690984 0.211608610379987 no 2679 0.222589938676335 3756 17217395 SGTC_1539 benzyladenosine 56 µM -0.764302121470076 0.211360844501324 no 2680 0.222343610721278 3756 92208 A nucleotide analog. SGTC_55 0767-0285 6.563 µM -0.766288493898947 0.210766169009849 no 2681 0.221752331537025 3728 3116166 SGTC_2702 st077768 96.8 µM -0.768545855977315 0.210091558063731 no 2682 0.221081479227381 3746 6484119 SGTC_1902 st060212 70.5 µM -0.769765862964533 0.209727488571221 no 2683 0.220719396418918 3787 688944 SGTC_1474 0330-0125 5.35 µM -0.769876293543261 0.209694552648322 no 2684 0.220686638776306 3794 X1474 SGTC_411 enrofloxacin 100 µM -0.770226545161543 0.209590110217472 no 2685 0.220582760096689 3828 71188 A bacterial gyrase inhibitor. SGTC_1793 st048256 72.231 µM -0.771079267422832 0.209335962730032 no 2686 0.220329974320469 3673 672022 SGTC_2607 solasodine 47.35 µM -0.771480679005686 0.209216387823367 no 2687 0.220211035130051 3822 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1291 0993-0025 5.79 µM -0.77267042861121 0.208862214306214 no 2688 0.219858725908241 3829 4353356 SGTC_4 0960-0234 25.671 µM -0.772872642408446 0.208802052938922 no 2689 0.219798878442781 3768 6821112 SGTC_2984 9022109 38.96 µM -0.774821525900737 0.208222757112501 no 2690 0.219222563856696 3826 6459207 SGTC_1570 verbenone 133 µM -0.776619850419149 0.207689056373365 no 2691 0.218691543260843 3803 29025 A natural terpanoid with antifungal properties. SGTC_1243 0416-0003 5.65 µM -0.778193261447533 0.207222768238698 no 2692 0.218227544389153 3814 2141977 SGTC_344 k064-0035 6.43 µM -0.778903555332834 0.207012472135019 no 2693 0.218018264727037 3794 5088750 SGTC_546 peri-Naphthalide 147 µM -0.779768688215463 0.206756503625909 no 2694 0.217763519948399 3749 223824 A penicillin ester. SGTC_658 3253-0951 102 µM -0.782970241563245 0.205810885135828 no 2695 0.216822293673991 3807 1184878 SGTC_1753 st043925 64 µM -0.78368709122867 0.205599506844091 no 2696 0.216611869429291 3858 670181 SGTC_3336 9143619 71.43 µM -0.783916674119797 0.205531836727039 no 2697 0.216544502588802 3814 45595730 SGTC_1727 st034309 9.9045 µM -0.78436720831091 0.205399079119571 no 2698 0.216412336928021 3920 870305 SGTC_1266 0828-0227 32.9 µM -0.785308878341131 0.205121764453238 no 2699 0.216136245795282 3848 3913820 SGTC_1460 k062-0059 9.15 µM -0.785532805204437 0.205055852455528 no 2700 0.216070622023036 3706 1373085 SGTC_2246 7293507 91.5585 µM -0.785573289585079 0.205043937380029 no 2701 0.216058758944793 3861 887656 SGTC_2211 7117706 200 µM -0.785850002513513 0.204962508215117 no 2702 0.215977684266874 3722 822771 SGTC_283 0987-0079 11.7 µM -0.786923147477899 0.204646892446935 no 2703 0.215663428134604 3842 411556 SGTC_2180 6301957 200 µM -0.787509078296658 0.204474690200274 no 2704 0.215491958090218 3752 845462 SGTC_1349 flufenamic acid 69 µM -0.787530558713443 0.204468378848384 no 2705 0.2154856734449 3773 3371 A non-steroidal anti-inflammatory. SGTC_298 1391-0729 10 µM -0.7890641918114 0.204018068212951 no 2706 0.215037244685422 3780 3237558 SGTC_2851 9015922 71.43 µM -0.789184675869506 0.203982716319199 no 2707 0.215002038555011 3807 2996893 SGTC_1422 4031-0024 15.5 µM -0.792109993217901 0.203125503398303 no 2708 0.214148271849187 3760 782427 SGTC_2683 piperine 63.03 µM -0.795267617800059 0.202202634642691 no 2709 0.213228922985634 3802 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2567 aureobasidin a 60 nM -0.796071647453668 0.201968044783629 no 2710 0.212995196275862 3978 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3306 9127676 59.7925 µM -0.79627012687749 0.20191015998567 no 2711 0.212937522483692 3833 41905287 SGTC_553 k007-0256 45.7 µM -0.797038613795358 0.201686131147873 no 2712 0.21271430291393 3880 6287000 SGTC_129 0088-0017 176.636 µM -0.797256269733143 0.201622707287029 no 2713 0.212651106030123 3699 182446 SGTC_3275 9138069 49.47 µM -0.799432743902124 0.200989150827986 no 2714 0.212019765166748 3931 17617007 SGTC_1039 k821-0043 94 µM -0.801595532861926 0.200360762576877 no 2715 0.21139348125162 3790 15992768 SGTC_3133 9127736 49.47 µM -0.801948529113523 0.200258313314529 no 2716 0.211291366243542 3797 27243420 SGTC_3175 9106517 49.47 µM -0.801956731396704 0.200255933159661 no 2717 0.211288993824782 3867 41468073 SGTC_1899 st063254 59.6 µM -0.803469079997364 0.199817367401199 no 2718 0.210851830653715 3768 3093813 SGTC_1207 2099-0101 141 µM -0.804243963883205 0.199592882940395 no 2719 0.21062804649785 3872 5837381 SGTC_1238 0333-0287 48.8 µM -0.804401179251229 0.199547356053562 no 2720 0.210582660179438 3840 7226 SGTC_2894 9048625 32.47 µM -0.806060653277931 0.199067181969531 no 2721 0.210103938687453 3853 4092861 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.807467594327754 0.198660624923261 no 2722 0.209698568610256 3948 16725076 SGTC_1590 st077108 57.8 µM -0.807995529664794 0.19850819925399 no 2723 0.209546577788914 3807 5489485 SGTC_1640 st009078 66.4 µM -0.808012969595416 0.198503165195413 no 2724 0.20954155799704 3811 690618 SGTC_1766 st045414 44.774 µM -0.809987833869573 0.197933616304584 no 2725 0.20897358405631 3880 253960 SGTC_1909 st060837 51.5 µM -0.811061884795669 0.19762427591572 no 2726 0.208665066463803 3866 678937 SGTC_889 0919-1524 82.7 µM -0.811097262132 0.197614091764524 no 2727 0.208654909009723 3891 3905452 SGTC_829 1635-0120 117 µM -0.812826265052932 0.197116746614524 no 2728 0.208158837223448 3875 285054 SGTC_2942 9052777 62.25 µM -0.813619589779218 0.196888801649198 no 2729 0.207931455928494 3933 6469503 SGTC_2413 inermin 26.06 µM -0.813619990371677 0.196888686587814 no 2730 0.207931341148467 3956 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_659 k018-0002 107 µM -0.8141365075698 0.196740362238379 no 2731 0.207783376831014 3816 6797879 YHR007C ERG11 SGTC_785 1270-0111 65.3 µM -0.814969475887732 0.196501307619896 no 2732 0.20754489126786 3815 6741994 SGTC_2312 7706453 155.7 µM -0.815788864541569 0.196266322060654 no 2733 0.207310451575374 3878 976098 SGTC_1446 4239-0190 62 µM -0.816349889423437 0.196105528769807 no 2734 0.207150024078821 3866 1340085 SGTC_214 4373-3496 70 µM -0.817826619299126 0.195682670700765 no 2735 0.206728097967289 3926 3779166 SGTC_212 3807-4682 38.772 µM -0.822920346602417 0.194228346780746 no 2736 0.205276645684207 3945 3125501 YBL034C STU1 SGTC_1626 st003712 1.76 µM -0.823069321643846 0.194185911825854 no 2737 0.205234286722777 3841 24207035 SGTC_3198 9112019 49.47 µM -0.824282786729086 0.193840471432829 no 2738 0.204889448434073 3907 45595555 SGTC_2688 kanamycin b 96.69 µM -0.825167278767322 0.193588916856146 no 2739 0.204638313776738 3967 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2560 caryophyllene 100 µM -0.82694240298946 0.193084662511872 no 2740 0.204134854006479 3917 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2903 5923464 63.88 µM -0.827170487204643 0.19301992948599 no 2741 0.204070218415048 3877 2876576 SGTC_1732 st034308 51.822 µM -0.827542382747929 0.192914409510678 no 2742 0.203964855034042 3749 830119 SGTC_788 1182-0090 188 µM -0.830390090073949 0.192107582142267 no 2743 0.203159133369872 3968 5715185 SGTC_3326 9140064 16.379 µM -0.830627572850937 0.192040390674549 no 2744 0.203092026655146 3839 1868434 SGTC_2358 9037157 4 µM -0.833218215254149 0.191308349609891 no 2745 0.202360835673861 3886 2388925 SGTC_2015 5119600 184 µM -0.833487120501419 0.191232462821097 no 2746 0.202285029312791 3912 2828786 SGTC_427 1354-0053 47.3 µM -0.83373123417619 0.191163588355693 no 2747 0.202216226589093 4005 6813657 SGTC_3072 9116419 49.47 µM -0.834362295811071 0.190985610513187 no 2748 0.2020384286033 3904 17170162 SGTC_522 1273-0010 11.6 µM -0.836481582029644 0.190388653947873 no 2749 0.201442016948945 4016 5705015 SGTC_288 1315-0019 35.1 µM -0.83728300389386 0.190163209873475 no 2750 0.201216755222912 3948 6811474 SGTC_2657 nystatin 74.44 µM -0.837636151048234 0.19006391985751 no 2751 0.201117541431468 3918 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2161 5662504 8.5105 µM -0.837657889388913 0.190057808998404 no 2752 0.20111143518197 3861 2859334 SGTC_2052 5265182 7.135 µM -0.838890845667828 0.189711410663792 no 2753 0.200765282645845 3905 1239884 SGTC_1813 st051246 8.6015 µM -0.839874916362971 0.189435215421232 no 2754 0.20048926152612 3812 5291959 SGTC_1268 0828-0275 2.46 µM -0.84076586233938 0.189185370689699 no 2755 0.200239557562225 3941 745337 SGTC_1715 st032160 10.2275 µM -0.842110523579077 0.188808676657516 no 2756 0.199863045636327 3837 5289825 SGTC_1262 0737-0114 49.6 µM -0.843800315198407 0.188335953565231 no 2757 0.199390499676837 3946 765919 SGTC_1175 0741-0056 27.6 µM -0.845978612157073 0.187727648305534 no 2758 0.198782337888285 3990 765927 SGTC_2067 5224629 34.075 µM -0.84704034657626 0.187431591686719 no 2759 0.198486316592018 3898 2835000 SGTC_1928 4'-methoxychalcone 40.3 µM -0.847169182804228 0.187395686322338 no 2760 0.198450413972044 3947 641818 SGTC_2666 tannic acid 100 µM -0.847305650252345 0.187357658850688 no 2761 0.198412389043558 3900 16134267 A thiamine antagonist. SGTC_2055 5235184 200 µM -0.847773136685215 0.187227427121445 no 2762 0.198282163189726 3947 2836034 SGTC_1168 k815-0004 80.5 µM -0.84983690121006 0.186653175704254 no 2763 0.197707885263949 3874 642433 SGTC_1839 st053978 48 µM -0.850238876892027 0.186541451245907 no 2764 0.197596145698767 3912 3788398 SGTC_3137 9097352 49.47 µM -0.851508723462708 0.186188784317981 no 2765 0.197243409770646 3930 44120435 SGTC_1970 st070122 35.8 µM -0.852747178377159 0.18584523390067 no 2766 0.196899760947896 3925 102928 SGTC_3083 9117465 49.47 µM -0.853593895532649 0.185610578926024 no 2767 0.196665021027833 3859 16420915 SGTC_2544 sphondin 68.51 µM -0.85445377259744 0.185372465124597 no 2768 0.19642680628802 3875 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3222 9128301 49.47 µM -0.855785769193709 0.185003988432582 no 2769 0.196058144068196 3938 4911358 SGTC_2862 9027634 71.43 µM -0.856895921077711 0.184697229675463 no 2770 0.195751203619999 3843 5012562 SGTC_2332 7982454 138.89 µM -0.860098179341183 0.183814150164931 no 2771 0.194867462376292 3874 2981748 SGTC_2718 lomofungin 53.02 µM -0.862777325231663 0.183077352353797 no 2772 0.194129954170793 3877 5351222 A RNA synthesis inhibitor. SGTC_562 3772-2733 112 µM -0.863090762515384 0.182991273824862 no 2773 0.194043783215801 3942 2876874 YIL048W NEO1 SGTC_1176 0848-0131 83.3 µM -0.863266875746646 0.18294291935372 no 2774 0.193995375957025 3974 6769040 SGTC_2603 homopterocarpin 100 µM -0.864044338876054 0.182729550755994 no 2775 0.193781766970634 3967 101795 A weak amylase inhibitor. SGTC_2139 5578692 56.4705 µM -0.867964402315513 0.181656088540349 no 2776 0.192706910261398 3863 650991 YMR113W FOL3 SGTC_3311 9131146 2.8755 µM -0.868519359335678 0.181504439724229 no 2777 0.192555039462607 3910 4900406 YPR165W RHO1 SGTC_2105 5350118 200 µM -0.869329014665826 0.18128333365687 no 2778 0.192333598620011 3928 2133313 SGTC_515 4092-1064 102 µM -0.870378101075337 0.180997093143199 no 2779 0.192046905083617 3928 717353 SGTC_964 1287-0107 19.4 µM -0.871255731523138 0.18075785162928 no 2780 0.191807267908065 3959 51516812 YPR165W RHO1 SGTC_2220 6782180 200 µM -0.872311415657994 0.180470335585386 no 2781 0.191519255817361 3834 833803 SGTC_145 3737-0113 38.366 µM -0.8727095091544 0.180361989173666 no 2782 0.191410716649169 3915 6849351 SGTC_619 1652-1634 108 µM -0.873431322121688 0.180165642339102 no 2783 0.191214012357489 3901 5400454 SGTC_2005 4024620 188 µM -0.873524399193405 0.180140333377626 no 2784 0.19118865655603 3912 236743 SGTC_1761 st044296 37 µM -0.873607717660554 0.180117679810787 no 2785 0.191165960915553 3932 1826700 SGTC_106 0092-0003 11.579 µM -0.875998492436093 0.17946841098188 no 2786 0.190515426670445 3854 1072148 SGTC_1259 0671-0132 43 µM -0.876962709689779 0.179206972886374 no 2787 0.190253446459043 3864 X1259 SGTC_507 nimesulide 162 µM -0.877111175439585 0.179166739139128 no 2788 0.190213127618866 3987 4495 A COX2 inhibitor. SGTC_2805 7950783 58.44 µM -0.878456922242139 0.178802305231294 no 2789 0.189847902687989 3968 1178958 YDL195W SEC31 SGTC_3012 9080433 71.4286 µM -0.880474936770583 0.178256693591016 no 2790 0.189301038400631 3915 17688859 SGTC_2696 st077691 74.316 µM -0.883880796209589 0.177338232254221 no 2791 0.188380282413939 3995 757133 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.884010467280463 0.177303322883999 no 2792 0.188345281206936 3927 15053 SGTC_1170 0310-0127 64.8 µM -0.885299165144305 0.176956622248976 no 2793 0.187997650072357 3971 774975 SGTC_1323 1348-1351 11.2 µM -0.885328396971141 0.176948762931835 no 2794 0.187989769273337 3895 6989654 SGTC_1130 3454-2858 15.9 µM -0.885608112817073 0.1768735692228 no 2795 0.187914369165683 3993 715628 YIL048W NEO1 SGTC_636 0kpi-0074 126 µM -0.885773713171071 0.176829061761161 no 2796 0.18786973879209 3960 616434 SGTC_2254 7938975 95.19 µM -0.886988653167937 0.17650274579226 no 2797 0.18754250475589 4018 2969277 SGTC_2464 5717415 7.67 µM -0.888146109270056 0.176192223714127 no 2798 0.187231081360167 3946 5285744 SGTC_805 3852-0218 479 µM -0.888202347499806 0.176177144947076 no 2799 0.187215958137202 3892 6615355 SGTC_1862 st057513 3.81 µM -0.889055733642327 0.175948432673469 no 2800 0.18698656373392 3928 5393163 SGTC_675 1309-0189 238 µM -0.890821150431451 0.175475888176231 no 2801 0.186512563266832 3979 4246530 SGTC_265 mycophenolic acid 32.932 µM -0.891198124785173 0.175375088758283 no 2802 0.186411445126827 4023 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1040 k898-0338 155 µM -0.891449797571217 0.175307814247061 no 2803 0.186343956301055 3946 20969351 SGTC_1957 st077035 62.4 µM -0.893869467126646 0.174661848883905 no 2804 0.185695867924836 3982 705593 SGTC_2080 5212524 12.4 µM -0.895780945491313 0.17415262231928 no 2805 0.185184884273564 3858 260183 SGTC_704 1310-0270 142 µM -0.899353168650072 0.173203498182039 no 2806 0.184232287723292 3976 5718033 SGTC_1619 st003326 88.7 µM -0.899359510249002 0.173201816181324 no 2807 0.184230599339917 3951 2849032 SGTC_280 3448-3607 3.04 µM -0.899845854393077 0.173072852700129 no 2808 0.184101144064155 3949 626179 SGTC_3140 9094243 49.47 µM -0.900030259934771 0.173023970029956 no 2809 0.184052073734094 3959 19291112 SGTC_1558 st069300 45.6 µM -0.901366786964555 0.172669943117633 no 2810 0.183696667201202 3886 24208000 SGTC_2064 5220758 200 µM -0.902092040402922 0.172478027273957 no 2811 0.183503988380955 4031 788518 SGTC_1501 4491-0275 38.4 µM -0.905016902111574 0.171705434572234 no 2812 0.182728216476401 3900 5104718 SGTC_2187 6125751 200 µM -0.905264568344316 0.171640116017345 no 2813 0.182662621206049 3976 874498 SGTC_686 1319-0111 510 µM -0.905541052336566 0.171567215930841 no 2814 0.182589410822197 3988 4562600 SGTC_1960 st011366 51.8 µM -0.906108939264105 0.171417544163867 no 2815 0.182439097139197 3988 3972846 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.907680320172078 0.171003827537057 no 2816 0.182023572220705 4011 5282309 SGTC_1436 4092-1007 8.32 µM -0.909832699466517 0.170438181948551 no 2817 0.181455373400003 3956 2881121 SGTC_1627 st003713 25.6 µM -0.911968134275527 0.169878174945396 no 2818 0.180892746216649 4042 16195070 YER133W GLC7 SGTC_847 0342-0274 5.54 µM -0.912798104301101 0.169660838226287 no 2819 0.180674367765921 3988 18097 SGTC_33 0986-0033 35.816 µM -0.918195388876484 0.168251854050206 no 2820 0.179258291159336 3902 2848082 SGTC_3102 9121669 49.47 µM -0.920417717430711 0.167673899715407 no 2821 0.178677256744412 4009 41905072 SGTC_1117 retinoic acid 1.10837 µM -0.92447909148775 0.166620978006431 no 2822 0.177618466276148 4038 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2166 5933061 31.504 µM -0.924539818438964 0.166605266836722 no 2823 0.177602665007879 4074 2877375 SGTC_1046 2001-0062 216 µM -0.925084951606492 0.16646427376306 no 2824 0.177460860046769 3913 739778 SGTC_2343 7990716 14.84 µM -0.926202879303316 0.166175374329813 no 2825 0.177170278249724 4007 6456862 SGTC_11 0438-0307 1.3 µM -0.926797156080942 0.166021930828933 no 2826 0.177015930913966 3980 4011476 SGTC_855 0428-0020 25 µM -0.928968336360052 0.165462106113186 no 2827 0.176452748009434 4033 6812414 SGTC_2993 9054257 71.4286 µM -0.929817513535598 0.165243483893429 no 2828 0.176232788449691 3953 6470217 YGL055W OLE1 SGTC_2423 st077119 87.2 µM -0.93069092247237 0.165018818275891 no 2829 0.176006733325785 3936 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2712 st079126 47.7 µM -0.931295076721352 0.164863528392874 no 2830 0.175850473991452 4009 3152970 SGTC_9 0092-0002 10.449 µM -0.931410747786289 0.164833807469641 no 2831 0.175820566683637 3972 759368 SGTC_3258 9138477 49.47 µM -0.931848453590941 0.16472137324195 no 2832 0.175707424915787 4036 4970355 SGTC_2317 5986382 200 µM -0.934461061512407 0.164051301886584 no 2833 0.17503305639088 4046 877883 SGTC_2452 5863136 48.41 µM -0.935053709136009 0.163899548364211 no 2834 0.174880310487897 3979 2184096 SGTC_3172 9105863 49.47 µM -0.936996322807353 0.163402761027563 no 2835 0.174380224714425 4033 2348785 SGTC_3054 9094397 49.47 µM -0.938722177723144 0.162962227062113 no 2836 0.173936701885341 4031 2598354 SGTC_1044 1222-0021 1.78 µM -0.938745707930616 0.162956226187522 no 2837 0.173930659881135 3989 4306703 SGTC_2117 5521686 200 µM -0.939902981567298 0.162661265667059 no 2838 0.173633663916244 3987 803312 SGTC_1842 st055362 61.2 µM -0.940780577299217 0.162437819844904 no 2839 0.173408658116706 3977 676032 SGTC_1704 st028805 70.8 µM -0.941140328976035 0.162346280745006 no 2840 0.173316475443583 4051 2876101 SGTC_1067 clotrimazole 1.36 µM -0.94132891104095 0.162298309305627 no 2841 0.173268165692239 4037 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1725 st036284 20.55 µM -0.943333890295527 0.161788854044679 no 2842 0.172755073158515 4124 707914 SGTC_1946 st076057 65.1 µM -0.945208652866009 0.161313429998314 no 2843 0.172276181382248 3953 953009 SGTC_2966 9084041 48.03 µM -0.946045665688267 0.16110146510845 no 2844 0.172062647505964 3936 17741380 SGTC_1897 st060201 15 µM -0.947153609937654 0.160821169254552 no 2845 0.171780255111371 4074 611878 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.949564342424544 0.160212385270798 no 2846 0.171166831965099 4073 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2895 9054447 58.44 µM -0.949743761025106 0.160167136872426 no 2847 0.171121234064134 4079 2697450 SGTC_2808 7946468 45.46 µM -0.950628999016252 0.159944006959406 no 2848 0.170896371157953 4048 2970879 SGTC_1336 1486-0901 104 µM -0.956083589741903 0.158573630228869 no 2849 0.169515002441822 4053 5006114 SGTC_1497 4476-2978 41.3 µM -0.956551748343331 0.158456372883764 no 2850 0.169396776582812 4079 1528379 SGTC_2194 5927483 104.545 µM -0.957767992586994 0.158152012137853 no 2851 0.169089881219477 4050 760979 SGTC_3228 9131799 49.47 µM -0.959150913456564 0.157806407647202 no 2852 0.16874136237136 4038 17015818 SGTC_3035 9091303 49.47 µM -0.96232543979865 0.157014942247489 no 2853 0.167943076930298 4104 25237002 SGTC_1859 st055998 20 µM -0.964581727605667 0.15645400008548 no 2854 0.167377177585629 3964 676301 SGTC_2336 9001819 198.65 µM -0.964601866369724 0.156448999279009 no 2855 0.167372132123166 4116 2989602 SGTC_1597 7-benzyloxygramine 47.5 µM -0.966680756844292 0.155933340760384 no 2856 0.166851824880706 3993 260807 SGTC_1480 1070-0044 41.2 µM -0.967648949054483 0.155693568286523 no 2857 0.166609861070663 4066 3124987 SGTC_2009 4012297 12.05 µM -0.968269152118149 0.155540103037381 no 2858 0.166454983327727 4059 45595307 SGTC_958 1222-0007 33 µM -0.968973173452827 0.155366018468028 no 2859 0.166279287078449 4141 7312461 SGTC_781 4335-2806 94.4 µM -0.969154746278485 0.155321141507026 no 2860 0.166233993022706 4133 845254 SGTC_505 gw-5074 63.9 µM -0.973159215554659 0.154333584611818 no 2861 0.165237088676814 4107 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_431 k089-0097 107 µM -0.973167759090816 0.154331482107238 no 2862 0.165234965925849 3890 5499420 SGTC_2553 4-methylesculetin 85.09 µM -0.973335227769002 0.154290273059328 no 2863 0.165193359751843 4089 5319502 SGTC_3022 9087993 49.47 µM -0.982314502135704 0.152091395474158 no 2864 0.162972466102247 4128 17173644 SGTC_205 1486-1330 71.903 µM -0.98269664519359 0.151998278875592 no 2865 0.162878381170739 4089 4118834 SGTC_1876 myriocin 605 nM -0.983588205609068 0.151781180076621 no 2866 0.162659013287037 4071 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_3006 9075424 71.4286 µM -0.986051473070766 0.151182435404357 no 2867 0.162053927414968 4016 7465181 SGTC_3041 9091929 49.47 µM -0.98748130691194 0.150835608434279 no 2868 0.161703371216413 4081 25236887 SGTC_3280 9140961 49.47 µM -0.993501147855085 0.149381221781292 no 2869 0.160232895683846 4121 4901226 SGTC_2077 5212015 200 µM -0.995516235734335 0.148896477176368 no 2870 0.159742625918138 3939 780900 SGTC_2869 9037858 32.47 µM -0.997477833537105 0.148425610684789 no 2871 0.159266314004073 4038 27187042 SGTC_1816 st051957 91.6 µM -1.00032586988071 0.147743735826775 no 2872 0.158576415807901 4067 674121 SGTC_966 1300-0360 30.2 µM -1.00353239451827 0.146978546184559 no 2873 0.157802027499934 4076 70588 SGTC_1829 berberine 14.4 µM -1.00495899512538 0.146638964842485 no 2874 0.157458297503485 4092 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2564 betulinic acid 100 µM -1.00787965027898 0.145945389233226 no 2875 0.156756121013554 4164 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_779 1360-0071 233 µM -1.00795626699252 0.145927224582548 no 2876 0.156737728799855 4147 7566 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.01008822558914 0.145422379093141 no 2877 0.156226511426154 4037 4330530 SGTC_385 1494-0393 12.4 µM -1.0125439639216 0.144842320470318 no 2878 0.155639018566484 4093 3090647 SGTC_3220 9131269 49.47 µM -1.01274540949629 0.144794807179073 no 2879 0.155590890953824 4115 17722206 SGTC_809 3998-0021 90 µM -1.01494397466374 0.144276932308915 no 2880 0.15506626729115 4053 715485 SGTC_3099 9120367 49.47 µM -1.01598164471317 0.144032942021038 no 2881 0.154819063700441 4137 24824940 SGTC_937 3122-0005 46.7 µM -1.0162093633117 0.143979435159284 no 2882 0.154764849272025 4146 759535 SGTC_1107 amlodipine 47 µM -1.01727003858442 0.143730385782257 no 2883 0.15451249279163 3834 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_367 0335-0881 7.1 µM -1.01874257152991 0.143385113304213 no 2884 0.154162598060643 4088 23828853 SGTC_2126 5251174 33.877 µM -1.01889602346457 0.143349164877403 no 2885 0.15412616587973 4134 790722 SGTC_907 3448-6986 75.5 µM -1.02000287731043 0.143090047968442 no 2886 0.153863548071498 4145 590582 SGTC_2878 9043973 25.97 µM -1.02047060846714 0.14298064624993 no 2887 0.153752660852382 4162 6465167 SGTC_632 0781-2353 4.65 µM -1.02122607480455 0.142804063040452 no 2888 0.153573670658152 4186 6811515 YHR007C ERG11 SGTC_1895 st058434 18.3 µM -1.02152720076595 0.142733718762844 no 2889 0.153502364335341 4136 5393175 SGTC_302 1094-0063 18.9 µM -1.02361403236519 0.142246869959722 no 2890 0.153008807334405 4089 5440289 SGTC_666 0272-0154 136 µM -1.02673442276781 0.141520994811997 no 2891 0.152272767830505 4130 6870312 SGTC_1868 st057644 42.7 µM -1.02711896957588 0.141431714329728 no 2892 0.152182223663349 4125 688665 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.02852679640433 0.141105183979876 no 2893 0.151851046300911 4107 2724 A muscle relaxant with antifungal properties. SGTC_2380 9035439 200 µM -1.0302856414174 0.140697957541932 no 2894 0.151437968678611 4229 6462575 SGTC_1559 coumarin 343 70.1 µM -1.03082461815807 0.140573327741046 no 2895 0.151311535751508 4151 108770 A hepatotoxic, DNA x-linker. SGTC_2665 lovastatin 100 µM -1.0312382114765 0.140477741692494 no 2896 0.151214562833236 4134 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_600 1495-0418 41.6 µM -1.03286062657154 0.140103209509783 no 2897 0.150834563465151 4109 5377768 SGTC_897 1000-0139 31.4 µM -1.0331781932383 0.140029979166665 no 2898 0.150760257986433 4075 6151020 SGTC_1467 k284-1082 293 µM -1.03779515703332 0.13896825256902 no 2899 0.149682716003426 4091 3334705 SGTC_2228 7354201 200 µM -1.03794183546293 0.13893461215944 no 2900 0.149648567505651 4175 753451 SGTC_356 1634-0012 32.5 µM -1.03978513925197 0.138512326715584 no 2901 0.14921986741571 4143 735457 SGTC_2938 9059746 27.26 µM -1.04086808774364 0.138264640562131 no 2902 0.148968387174035 4135 6471769 SGTC_2174 5790901 200 µM -1.0425017554593 0.137891568482361 no 2903 0.148589556006849 4143 786020 SGTC_3110 9122132 49.47 µM -1.04301605035991 0.137774263922871 no 2904 0.148470429591814 4234 918317 SGTC_2569 tetrandrine 100 µM -1.04514668246143 0.137289017543087 no 2905 0.14797759061091 4156 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1763 st044482 94.5 µM -1.046041541841 0.13708556392999 no 2906 0.147770926559596 4133 88505 SGTC_2889 9059656 51.95 µM -1.04709018454524 0.136847408674602 no 2907 0.147528992946499 4215 3949838 SGTC_852 0418-0143 439 µM -1.04833543875621 0.136564968855087 no 2908 0.147242043694209 4152 5369229 SGTC_1093 fluphenazine 7.97 µM -1.04843915912988 0.13654146172622 no 2909 0.147218159854537 4142 6602611 An atypical antipsychotic. SGTC_3241 9133421 49.47 µM -1.04977073179161 0.136239920632172 no 2910 0.146911767386318 4183 17018221 SGTC_2661 dactinomycin 12.96 µM -1.05028008054693 0.136124696716474 no 2911 0.14679468032751 4100 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1723 st034307 2.5525 µM -1.05507550567285 0.135043154634779 no 2912 0.145695396758178 4170 867466 SGTC_2047 4141938 200 µM -1.06030577645726 0.133870274766746 no 2913 0.144502756077594 4138 3807862 SGTC_2540 epiandrosterone 100 µM -1.06206574927828 0.133477182691204 no 2914 0.144102918856618 4197 441302 A steroid. SGTC_1239 0337-0584 35.4 µM -1.06224901218585 0.133436296381758 no 2915 0.144061327428487 4234 914301 YML130C ERO1 SGTC_2395 5646831 180.19 µM -1.06254410952555 0.133370477699837 no 2916 0.143994372243956 4185 6808628 SGTC_3109 9122853 49.47 µM -1.06343853984487 0.133171119892979 no 2917 0.143791561511065 4185 1234709 SGTC_3121 9125696 49.47 µM -1.06349465366476 0.133158619634542 no 2918 0.143778844214621 4254 1235365 SGTC_3278 9139605 49.47 µM -1.06411231471569 0.13302107903503 no 2919 0.143638911403322 4175 7958859 SGTC_1880 MG-132 525 µM -1.06732375680251 0.132307532257017 no 2920 0.142912831968835 4120 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2963 9082507 9 µM -1.06857768731879 0.132029640293015 no 2921 0.142630003551776 4206 16459611 SGTC_3229 9132204 49.47 µM -1.06961164785609 0.131800800347774 no 2922 0.142397075024111 4216 17682924 SGTC_709 3807-1509 243 µM -1.06970042175724 0.13178116534554 no 2923 0.142377088222202 4234 1886677 YPL242C IQG1 SGTC_483 fpl-64176 144 µM -1.07002995781254 0.131708296246021 no 2924 0.142302912160648 4245 3423 SGTC_1209 2323-2347 50.3 µM -1.07226178220791 0.131215512929062 no 2925 0.141801233696681 4178 5412760 SGTC_1114 scopoletin 1.73284 µM -1.07362743740966 0.130914607166647 no 2926 0.141494847617171 4205 5280460 A coumarin with genotoxic properties. SGTC_953 1188-0045 9.7 µM -1.07490597062927 0.130633330184581 no 2927 0.14120841429426 4189 6144426 SGTC_1411 3909-8223 150 µM -1.07507388272957 0.130596420629795 no 2928 0.141170825708815 4190 X1411 SGTC_625 k213-0058 121 µM -1.07644101104571 0.130296174028698 no 2929 0.140865034625029 4221 3655420 SGTC_2144 5628481 200 µM -1.07992672875045 0.129532808290366 no 2930 0.140087404834332 4160 2818399 SGTC_701 4424-0219 185 µM -1.08027511591205 0.129456682809911 no 2931 0.140009843668539 4234 2911779 SGTC_1675 st018485 24.5 µM -1.08042643585477 0.129423627806997 no 2932 0.139976164517286 4211 3323024 SGTC_909 3448-9333 149 µM -1.08302180710145 0.128857593607261 no 2933 0.139399371877927 4100 3344074 SGTC_647 0140-0236 81 µM -1.0833952242727 0.128776295182915 no 2934 0.139316517271674 4188 990837 SGTC_960 1222-0186 7.7 µM -1.08987290483782 0.12737166929518 no 2935 0.137884566777936 4214 3126296 SGTC_1322 1348-1070 12 µM -1.09099150466296 0.127130194215274 no 2936 0.137638310368927 4177 6758089 SGTC_2462 5162487 171.77 µM -1.09255288487807 0.126793667898062 no 2937 0.137295079370253 4105 2259986 SGTC_204 PMA1.184 62.41 µM -1.09342447822593 0.12660608222963 no 2938 0.137103735473642 4183 2252213 YGL008C PMA1 SGTC_1369 1866-0067 208 µM -1.09376676359144 0.126532467929775 no 2939 0.137028642231649 4209 3531355 SGTC_2990 9074105 71.4286 µM -1.0954127947824 0.126178877347776 no 2940 0.136667915596756 4100 6502001 SGTC_1879 gemcitabine 100 µM -1.09733685894092 0.125766435166178 no 2941 0.136247081959544 4168 60750 A nucleoside analog which inhibits DNA replication. SGTC_1557 sumaresinolic acid 42.3 µM -1.09880218318525 0.12545295989153 no 2942 0.135927179871916 4165 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_3204 9114183 49.47 µM -1.10460949505711 0.124215972914479 no 2943 0.13466441749948 4180 17027248 SGTC_2763 lisinopril 49.32 µM -1.10466703779945 0.124203758857874 no 2944 0.13465194561794 4072 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_552 k242-0005 476 µM -1.10510565576368 0.1241106851573 no 2945 0.134556905096496 4272 4088318 SGTC_1743 st037606 46.3785 µM -1.10607138134943 0.123905932486823 no 2946 0.134347812288587 4175 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2327 6189656 200 µM -1.10701853185874 0.123705347855548 no 2947 0.134142958065765 4271 5349088 SGTC_2884 9058502 51.95 µM -1.10808178772375 0.123480445782921 no 2948 0.133913247788805 4240 6471554 SGTC_1019 4262-0212 3.4 µM -1.10951410783268 0.12317793148143 no 2949 0.133604230908508 4231 4677213 SGTC_1468 k284-1086 134 µM -1.1096388840007 0.123151602648281 no 2950 0.133577334226242 4187 15996457 SGTC_40 0327-0103 19.753 µM -1.11041275767221 0.122988396809393 no 2951 0.133410601605439 4061 409036 SGTC_1898 st060199 18.6 µM -1.11081906785325 0.122902768886566 no 2952 0.133323118606541 4188 688866 SGTC_1553 gossypol 38.6 µM -1.11298670710065 0.122446655701168 no 2953 0.132857069294953 4087 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2528 xanthyletin 44.79 µM -1.11299103776304 0.122445745636677 no 2954 0.13285613931304 4234 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2308 7584454 197.62 µM -1.11374651016579 0.122287059967185 no 2955 0.132693975062849 4272 893577 SGTC_102 gallobenzophenone 83.616 µM -1.11557231211111 0.121904149616582 no 2956 0.132302624675257 4206 70837 SGTC_2822 7994718 71.43 µM -1.11618311442429 0.121776239301744 no 2957 0.132171880402943 4175 1018011 SGTC_3232 9132874 49.47 µM -1.11814080464061 0.121366907908648 no 2958 0.131753430707473 4165 3784940 SGTC_2474 5321570 43.32 µM -1.12067272618413 0.120838947124719 no 2959 0.131213597844853 4201 2841384 SGTC_512 prima-1 270 µM -1.12114301485032 0.120741059965497 no 2960 0.131113495718177 4224 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1795 st049545 62.3 µM -1.12121477935253 0.120726127617222 no 2961 0.131098225103644 4171 5291882 SGTC_104 0074-0074 590.992 µM -1.12246944056606 0.120465274883709 no 2962 0.130831446933496 3978 3943124 SGTC_108 0509-0257 621.132 µM -1.12315473938151 0.120322964258659 no 2963 0.13068589063438 4174 536624 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.12354072390295 0.120242862039678 no 2964 0.130603957484116 4157 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2444 5485484 36.41 µM -1.12452373414556 0.120039030554461 no 2965 0.130395453783197 4289 6790631 SGTC_1798 st045719 60.953 µM -1.12571591373421 0.119792153813711 no 2966 0.130142892816628 4146 3980186 SGTC_3281 9140613 49.47 µM -1.13130832244513 0.118638856087299 no 2967 0.128962671339108 4229 16013766 SGTC_828 2074-0507 139 µM -1.13297294967338 0.118297087524584 no 2968 0.128612806544117 4290 X828 SGTC_2725 haloperidol 53.21 µM -1.1337609185972 0.118135550720588 no 2969 0.128447424234325 4161 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_417 st075190 100 µM -1.13390662975044 0.118105696445921 no 2970 0.128416857930718 4228 222757 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.13426197237617 0.118032913848326 no 2971 0.128342337722916 4218 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_308 4092-1169 104 µM -1.13488789115492 0.117904788008179 no 2972 0.128211147028162 4157 2268590 YDL196W YDL196W SGTC_39 0986-0283 58.349 µM -1.13529734198992 0.117821026505231 no 2973 0.128125377767088 4309 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1505 k297-0037 20.6 µM -1.13975873732555 0.116911085446386 no 2974 0.127193414368793 4226 4089396 SGTC_1151 3909-8316 15.3 µM -1.14027799316988 0.116805503098871 no 2975 0.127085251595608 4272 800431 SGTC_1281 0884-0031 11.8 µM -1.14117778604988 0.116622704732684 no 2976 0.126897973244 4251 1548255 SGTC_2534 helenine 20.12 µM -1.14187512142986 0.1164811764298 no 2977 0.126752965576241 4241 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_109 0132-0036 33.701 µM -1.14206336858453 0.116442991457324 no 2978 0.126713840236163 4041 67274 A color developer. SGTC_1427 4048-4900 550 nM -1.14398062981557 0.116054590520499 no 2979 0.126315835114807 4228 24132586 SGTC_832 4083-0019 164 µM -1.14490121238098 0.115868425015091 no 2980 0.126125040857669 4311 1990758 SGTC_604 1000-0114 314 µM -1.14517479712198 0.115813140029946 no 2981 0.126068378116948 4249 1572745 SGTC_2830 7992007 71.43 µM -1.14685763688142 0.115473490019238 no 2982 0.125720231780874 4121 1952075 SGTC_3052 9092717 49.47 µM -1.14799771813718 0.115243788315104 no 2983 0.125484752916342 4237 25237534 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.14807757395526 0.115227711276752 no 2984 0.125468270584938 4277 5393153 SGTC_1261 0712-0010 12.7 µM -1.14949622342952 0.114942366226773 no 2985 0.125175711557982 4258 2840123 SGTC_359 0081-0058 15.9 µM -1.15205559281852 0.114428850426172 no 2986 0.124649114776769 4341 3494159 SGTC_2543 pimpinellin 60.67 µM -1.15366259537196 0.114107254837861 no 2987 0.124319262333955 4062 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_883 0850-0245 24.6 µM -1.15390300134744 0.114059199874147 no 2988 0.124269969281196 4310 6823229 YPR165W RHO1 SGTC_2225 6654152 15.4 µM -1.15738631869113 0.113364533768299 no 2989 0.123557280577272 4146 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1250 0485-0349 40.2 µM -1.15801361940768 0.113239754655542 no 2990 0.123429239273115 4261 6842794 YDL195W SEC31 SGTC_981 1488-1094 54.9 µM -1.16175894266804 0.112496794812539 no 2991 0.122666697885198 4219 3449522 SGTC_2782 7736369 71.43 µM -1.16203738861606 0.112441698872542 no 2992 0.122610139031617 4270 2950836 YOL077C BRX1 SGTC_1410 3909-8106 77.9 µM -1.16534916205281 0.111787877923343 no 2993 0.121938843338284 4294 1039210 SGTC_1821 st053465 65.6 µM -1.16567886883748 0.111722935292113 no 2994 0.121872153423658 4266 675086 SGTC_2764 methyldopa 94.69 µM -1.16588105870788 0.111683123130191 no 2995 0.121831269079192 4261 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1581 himbacine 57.9 µM -1.16702636010764 0.111457799316079 no 2996 0.12159986221664 4250 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1399 3562-5772 25 µM -1.16999690294238 0.11087489864421 no 2997 0.121001107592084 4234 23847490 SGTC_2279 7948423 32.93 µM -1.17335332012682 0.110218910658115 no 2998 0.120327074149209 4253 1247112 SGTC_3291 9121177 71.43 µM -1.17420373376896 0.110053146229766 no 2999 0.120156715429139 4249 17015612 SGTC_127 0180-0333 59.125 µM -1.17459756897702 0.109976439663005 no 3000 0.120077878179808 4174 771601 SGTC_1434 4073-0095 163 µM -1.17602036621912 0.10969964369015 no 3001 0.119793368858738 4250 24133745 SGTC_1377 2944-0135 198 µM -1.17709648106268 0.109490624961901 no 3002 0.119578499740544 4279 1894137 SGTC_1006 4099-6547 255 µM -1.17719867625846 0.109470790000376 no 3003 0.119558108449001 4274 3146833 SGTC_2325 6158266 200 µM -1.17734142427641 0.109443088502897 no 3004 0.119529629646312 4266 3623240 SGTC_1255 0566-0045 221 µM -1.18085878487827 0.108762103751365 no 3005 0.11882941333884 4279 2788469 SGTC_2374 9071832 200 µM -1.18417029445396 0.108123762804151 no 3006 0.118172829257884 4193 17381698 SGTC_1648 st011736 69.8 µM -1.18447456877079 0.108065245145637 no 3007 0.118112628718638 4268 2855514 SGTC_2493 resveratrol 26.09 µM -1.18733369743788 0.107516494586582 no 3008 0.117548010663305 4194 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1483 3453-0561 55.9 µM -1.19139227977604 0.106740986560762 no 3009 0.116749811131675 4308 4546991 SGTC_3 0833-0587 95.581 µM -1.19397570002731 0.106249457592592 no 3010 0.116243736823216 4157 5382644 SGTC_2038 4100038 30.985 µM -1.19572499385574 0.105917561491831 no 3011 0.115901947236434 4253 3596803 SGTC_2874 9043904 71.43 µM -1.19763632147479 0.10555577978334 no 3012 0.115529314765066 4216 4463428 SGTC_789 1309-1135 70.6 µM -1.20011806663266 0.10508736238116 no 3013 0.115046744952204 4250 3092424 SGTC_2872 9044037 25.97 µM -1.2014380776758 0.1048388304455 no 3014 0.11479065650258 4315 6465195 SGTC_1556 plumbagin 1.48 µM -1.20153145428845 0.104821265610274 no 3015 0.114772556364635 4220 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2242 6630449 61.2675 µM -1.20345566855902 0.104459780875981 no 3016 0.11440001832768 4336 691249 YDR170C SEC7 SGTC_2815 7968870 71.43 µM -1.2056580603096 0.10404714699711 no 3017 0.113974681178648 4236 2977326 YHR190W ERG9 SGTC_1742 st038235 28.8875 µM -1.207217904124 0.103755614875419 no 3018 0.113674118538067 4327 564103 YBR002C RER2 SGTC_1646 st011709 75.6 µM -1.20871151248214 0.103477017852578 no 3019 0.113386848598584 4252 5757843 SGTC_687 k029-0044 34.9 µM -1.20958108745265 0.103315069656732 no 3020 0.11321983944102 4365 5829338 SGTC_2355 9061122 103.12 µM -1.21251135003045 0.102770697362874 no 3021 0.11265835027641 4303 5302957 SGTC_2216 7189485 200 µM -1.21298249125443 0.102683365531111 no 3022 0.112568257335699 4300 731273 SGTC_471 1-acyl-paf 4 µM -1.21581304064718 0.102159823606451 no 3023 0.112028074988896 4243 16759367 SGTC_1450 4112-4260 37.6 µM -1.21824661935227 0.101711260611058 no 3024 0.11156513429587 4308 1633175 SGTC_1623 st003709 20.3 µM -1.22031805273882 0.10133058025126 no 3025 0.111172164422752 4279 16192618 SGTC_3182 9108849 49.47 µM -1.22036933545319 0.101321168888989 no 3026 0.111162448210616 4318 17133045 SGTC_3206 9114350 49.47 µM -1.22088906823537 0.101225823879008 no 3027 0.111064012027882 4165 17087243 SGTC_415 dibenzyl ketone 100 µM -1.22151855597534 0.101110431880488 no 3028 0.110944872122619 4283 7593 SGTC_2190 6049624 200 µM -1.22320148414243 0.100802403540544 no 3029 0.110626802585962 4184 2265554 SGTC_2394 5221648 200 µM -1.22508183546036 0.100459050654575 no 3030 0.110272194197952 4336 788586 SGTC_1414 3917-0015 5.4 µM -1.22526364307406 0.100425897811108 no 3031 0.110237951052656 4302 6618702 SGTC_1810 st050138 53 µM -1.22755276275597 0.100009156888073 no 3032 0.109807451777117 4311 3444541 SGTC_3079 9117512 49.47 µM -1.22829659199157 0.0998740128215497 no 3033 0.109667824933929 4375 7185044 SGTC_2014 4013930 200 µM -1.23352697017993 0.0989274863846628 no 3034 0.108689610392612 4285 64556 SGTC_3157 9099274 49.47 µM -1.2341657784263 0.0988123343346194 no 3035 0.108570568274596 4340 17217662 SGTC_2585 alliin 100 µM -1.23633561198696 0.0984219309422946 no 3036 0.1081669194825 4375 87310 A garlic compound which reacts with lipids. SGTC_2546 rhodinyl acetate 100 µM -1.2363629198375 0.098417024833679 no 3037 0.108161846362871 4254 6708682 SGTC_1674 st016616 23.6 µM -1.23709880277927 0.098284884065406 no 3038 0.1080252021001 4263 625830 SGTC_2987 9018338 71.43 µM -1.23833078776924 0.0980639503838714 no 3039 0.107796716199615 4322 5055682 SGTC_587 k089-0003 57 µM -1.23877902433168 0.0979836578106064 no 3040 0.107713671959616 4232 9659696 SGTC_551 k048-0028 34.9 µM -1.23905491870611 0.0979342608356933 no 3041 0.107662580266205 4292 6836383 SGTC_1965 Pectolinarigenin 58.4 µM -1.24113922694192 0.0975616695415105 no 3042 0.107277160328579 4292 5320438 An anti-inflammatory. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.24154875473643 0.0974885846361151 no 3043 0.107201549553992 4263 1241132 A phosphatase inhibitor. SGTC_2545 solidagenone 89.61 µM -1.24281754827785 0.0972624088956743 no 3044 0.106967537231816 4188 6708572 An anti ulcer agent SGTC_2916 7875993 68.79 µM -1.2428835877581 0.0972506472166838 no 3045 0.106955367213056 4156 1299250 SGTC_3097 9117246 49.47 µM -1.24411109547893 0.0970322171551492 no 3046 0.106729338999253 4333 16423892 SGTC_1 0258-0098 57.368 µM -1.24480889901133 0.0969082064818013 no 3047 0.106601002113492 4265 6790032 YDR047W HEM12 SGTC_1056 3448-1962 115 µM -1.24611126918747 0.0966770661242008 no 3048 0.106361774085036 4302 715507 SGTC_1835 st008666 49.2 µM -1.24671230459215 0.0965705330044426 no 3049 0.106251502735044 4263 690455 SGTC_3106 9121286 49.47 µM -1.24724908073546 0.0964754627201887 no 3050 0.106153090789768 4289 15943471 SGTC_2165 5727197 32.143 µM -1.24742869626443 0.0964436657512943 no 3051 0.106120174984935 4418 1361712 SGTC_948 3448-0295 75.3 µM -1.24901294219907 0.0961635433745261 no 3052 0.105830170107824 4311 678569 SGTC_1163 k060-0048 49.9 µM -1.25039646458878 0.0959194020791164 no 3053 0.105577377714724 4317 6809982 SGTC_1236 0330-0013 258 µM -1.25081353338975 0.0958458941301986 no 3054 0.105501258080462 4334 4617066 SGTC_2678 equilin 100 µM -1.25186640960303 0.0956605101266532 no 3055 0.105309273207977 4315 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_777 1315-0167 517 µM -1.25249597307119 0.0955497865593067 no 3056 0.105194597377813 4347 4221767 SGTC_898 1000-0849 28.3 µM -1.2547181495234 0.0951597184711369 no 3057 0.10479054737857 4341 6751807 SGTC_21 0849-0113 22.993 µM -1.25648971404113 0.0948495892934583 no 3058 0.104469236453289 4296 1560156 SGTC_3088 9117578 49.47 µM -1.258924983334 0.0944244886938232 no 3059 0.104028714471933 4396 678341 SGTC_725 1497-0963 19 µM -1.25914654619482 0.0943858825158131 no 3060 0.103988702356872 4433 3549977 SGTC_586 0957-0265 8.15 µM -1.25937848689068 0.0943454805256389 no 3061 0.10394682806234 4205 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1112 tnp00069 1.16933 µM -1.26192344187154 0.0939030096294549 no 3062 0.103488167950629 4338 145826 SGTC_761 k216-0224 480 µM -1.26926252023239 0.0926356021942006 no 3063 0.102173724570176 4358 1340404 SGTC_376 3970-0862 59.1 µM -1.27022002688222 0.0924711850579132 no 3064 0.102003132917384 4367 3135186 SGTC_2619 obliquin 87.91 µM -1.27152169609439 0.0922480168580554 no 3065 0.101771556974648 4299 6708593 A bioactive alkalod. YER133W GLC7 SGTC_631 k072-0230 41.5 µM -1.27177039920474 0.0922054226788099 no 3066 0.101727354556788 4334 5773147 SGTC_3046 9092212 49.47 µM -1.27262353726891 0.0920594204728447 no 3067 0.101575831119566 4421 25236637 SGTC_1642 st009582 77.7 µM -1.27573080156341 0.0915291042635144 no 3068 0.101025348183739 4313 6739311 SGTC_874 0599-0792 117 µM -1.27649225673478 0.0913994929170198 no 3069 0.100890781150092 4357 765305 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.2773784972916 0.0912488125641275 no 3070 0.100734326227884 4262 5355888 SGTC_3063 1327-0034 4 µM -1.2785252880106 0.0910541064363459 no 3071 0.100532137082505 4229 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1111 tnp00062 510.699 nM -1.28206941823009 0.0904543195416287 no 3072 0.0999091478721359 4380 676306 SGTC_1953 st076800 12.1 µM -1.28282142526766 0.090327432585764 no 3073 0.0997773230370407 4338 297591 SGTC_168 3970-0862 530.542 µM -1.28896607309739 0.0892955886570235 no 3074 0.0987049408046737 4311 3135186 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.29129305177685 0.0889071271336644 no 3075 0.098301039531896 4414 4620898 SGTC_1594 piperine 70.1 µM -1.29585597857893 0.0881490551912651 no 3076 0.0975125539845462 4349 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2349 9023730 187.07 µM -1.29724134729871 0.0879198501827033 no 3077 0.097274079121097 4410 4126287 SGTC_2924 9010168 62.78 µM -1.29933298244733 0.0875746380850952 no 3078 0.0969148400089379 4394 2993929 SGTC_929 2805-0021 398 µM -1.30074688282618 0.0873418557370558 no 3079 0.0966725544559407 4413 3098024 SGTC_169 k015-0017 16.025 µM -1.30249211261041 0.0870551611764753 no 3080 0.0963741062498186 4355 1840002 SGTC_320 4092-0846 5.34 µM -1.3030288333071 0.0869671337953424 no 3081 0.0962824590068634 4324 1359356 SGTC_1463 k081-0032 34.1 µM -1.30353469133379 0.0868842290718602 no 3082 0.0961961403424347 3928 977755 SGTC_1808 st050063 61.5 µM -1.30464415138901 0.0867026072113637 no 3083 0.096007023387568 4345 4011993 SGTC_341 1486-1430 230 µM -1.30518987949084 0.0866133740986224 no 3084 0.0959140997423618 4330 2054753 YPL210C SRP72 SGTC_112 phenothiazine 287.218 µM -1.30618463283131 0.086450896585853 no 3085 0.0957448887015939 4329 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1959 st077091 55.8 µM -1.30638109610561 0.0864188343256043 no 3086 0.0957114955939229 4377 821356 YKL052C ASK1 SGTC_2428 5615643 7.78 µM -1.30686425035389 0.0863400227154708 no 3087 0.0956294097131378 4356 2253075 SGTC_513 4245-1575 41.7 µM -1.30843640559645 0.0860839464056896 no 3088 0.0953626656662564 4214 719745 SGTC_1283 0922-0125 16.4 µM -1.30934897617555 0.0859355656528133 no 3089 0.0952080833288112 4361 3360884 SGTC_1991 st073000 8.92 µM -1.31233939982212 0.0854506745161285 no 3090 0.0947028219708039 4415 4301969 YIL048W NEO1 SGTC_844 0330-0132 15.3 µM -1.31268226419086 0.085395210957655 no 3091 0.0946450181966221 4434 2828079 SGTC_230 MPP+ 141.667 µM -1.32593189585984 0.0832724798159621 no 3092 0.0924311284128789 4347 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1292 0kpi-0043 232 µM -1.3263530237243 0.0832056671178393 no 3093 0.0923613955941291 4408 3333905 SGTC_1119 parthenolide 318.541 nM -1.32758456236269 0.0830105125721709 no 3094 0.0921576936192649 4440 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2516 gossypol 71.55 µM -1.32987782659469 0.0826480304733957 no 3095 0.0917792640975451 4403 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2492 derrusnin 100 µM -1.33099204504366 0.0824723434489368 no 3096 0.0915958142274106 4422 1715307 Part of coumarin class of compounds. SGTC_737 1950-0117 57.9 µM -1.33338427822548 0.0820960925089852 no 3097 0.0912028645340796 4375 5393513 SGTC_1624 st003710 6.25 µM -1.33395332888827 0.0820067827817775 no 3098 0.0911095762332483 4426 24207033 SGTC_2079 5212404 121 µM -1.33810808319971 0.0813569315021137 no 3099 0.0904306030839044 4343 758462 SGTC_770 0389-1121 67.2 µM -1.34188208084547 0.0807700085997499 no 3100 0.0898171163556099 4454 6753108 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.34243406007069 0.0806844348181738 no 3101 0.0897276486486551 4402 6708561 SGTC_812 4251-0442 148 µM -1.34297086176452 0.080601279709126 no 3102 0.0896407045586694 4421 5723007 SGTC_1077 5-fluorocytosine 377 nM -1.34397494423826 0.080445912668259 no 3103 0.0894782446554186 4450 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1498 4478-3555 97.6 µM -1.3443651399845 0.0803855966843175 no 3104 0.0894151703522061 4386 3437919 SGTC_1043 0916-0009 19.3 µM -1.34481153984673 0.0803166346509687 no 3105 0.0893430513419967 4412 3101130 SGTC_2313 7726885 200 µM -1.34963107654095 0.0795749336446228 no 3106 0.0885671753449077 4413 726423 SGTC_2532 xanthone 78.9 µM -1.35297320628103 0.0790636487024182 no 3107 0.0880320951449986 4426 7020 An insecticide. SGTC_70 0141-0289 43.283 µM -1.36788101004806 0.0768132873306955 no 3108 0.085674662404572 4373 352408 SGTC_1371 2421-0008 32.7 µM -1.36827281219012 0.0767548077333598 no 3109 0.0856133488321816 4415 2827552 SGTC_1204 4049-0315 18.3 µM -1.37116666077303 0.0763239256812248 no 3110 0.0851615042486171 4454 588402 SGTC_2417 cerulenin 830 nM -1.37119798487009 0.0763192717435423 no 3111 0.0851566231092911 4423 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2159 5658611 73.75 µM -1.37158616244513 0.0762616166741904 no 3112 0.0850961519669563 4398 793844 SGTC_3053 9095903 49.47 µM -1.37460455192852 0.0758144330405335 no 3113 0.0846270383196637 4527 17174018 SGTC_2198 6589944 200 µM -1.37524984728941 0.0757190901989189 no 3114 0.0845269996091748 4419 5290268 SGTC_2335 9018011 154.17 µM -1.37728444890243 0.0754190743323512 no 3115 0.0842121606395093 4398 6458208 SGTC_1607 st000305 50.6 µM -1.37793975751916 0.0753226377563565 no 3116 0.084110944297649 4435 5457690 SGTC_488 nitrendipine 139 µM -1.38231157604731 0.0746816756358627 no 3117 0.0834380265532137 4446 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2883 9059145 45.46 µM -1.38295082946038 0.0745883031086075 no 3118 0.0833399716151346 4408 16476510 SGTC_2654 protoveratrine a 100 µM -1.38376773838877 0.0744691110550316 no 3119 0.0832147922467436 4446 5702278 A heart drug and vasodilator. SGTC_133 0724-0033 378.92 µM -1.38412981759081 0.0744163279951574 no 3120 0.0831593541325073 4267 280309 SGTC_361 000s-0510 1.45 µM -1.38620612299483 0.0741142004205008 no 3121 0.0828419861832121 4331 660 SGTC_643 k048-0106 28.4 µM -1.39507687812625 0.07283394276062 no 3122 0.0814963289228504 4449 6763920 SGTC_479 n-linoleoylglycine 10 µM -1.39611528905945 0.0726851895626357 no 3123 0.0813398902338124 4467 6433346 An anti-infammatory. SGTC_1162 k048-0130 20.1 µM -1.40344692387941 0.0716415392491085 no 3124 0.0802418043428851 4411 6797406 SGTC_2453 5731132 22.18 µM -1.40895724526587 0.070864747427658 no 3125 0.0794239054056749 4469 1362040 SGTC_2333 9017922 200 µM -1.40987519600066 0.070735974718477 no 3126 0.0792882689504379 4458 3163164 SGTC_1430 4049-0248 69.1 µM -1.4139287334602 0.0701694822607764 no 3127 0.0786914141946718 4478 22774488 SGTC_2425 5628681 7.85 µM -1.4177671561783 0.0696362754914499 no 3128 0.0781293780327892 4502 5714958 SGTC_693 4161-2696 114 µM -1.42257482909747 0.0689728341868018 no 3129 0.0774297225353366 4490 805759 SGTC_654 1124-0271 80.9 µM -1.42685414808201 0.0683864116197777 no 3130 0.0768109698055059 4438 5403748 SGTC_101 0490-5701 117.494 µM -1.42717416523073 0.0683427126892217 no 3131 0.0767648495906658 4322 4661669 SGTC_1429 4049-0205 9.46 µM -1.42995717643341 0.0679635953568911 no 3132 0.0763646551015817 4505 22774478 SGTC_1014 4130-3005 69.3 µM -1.43018348252745 0.0679328382127877 no 3133 0.0763321824132596 4475 743608 SGTC_2504 purpurogallin 52.29 µM -1.43154882494683 0.0677475032195156 no 3134 0.0761364921526859 4384 5281571 An antioxidant. SGTC_901 1112-0062 60.1 µM -1.43668972658746 0.0670531667498316 no 3135 0.0754030876893739 4446 1908457 SGTC_3316 9136639 10.545 µM -1.43817936423422 0.0668530063492863 no 3136 0.0751915843666855 4445 4903665 SGTC_2491 paeonol 100 µM -1.44536753938552 0.0658936328304857 no 3137 0.0741773380598839 4428 11092 Increases levels of cortical cytochrome oxidase. SGTC_804 1595-0054 20.9 µM -1.44605332850934 0.0658026640122589 no 3138 0.0740811223797512 4435 761523 Stimulates phospholipase C. SGTC_1967 st070177 51.4 µM -1.44606207585 0.065801504320704 no 3139 0.0740798957507503 4462 5729214 SGTC_48 0382-0018 55 µM -1.44617584214088 0.065786423030128 no 3140 0.0740639438544939 4486 762596 SGTC_257 daunorubicin 18.5 µM -1.45238728198903 0.0649670704683164 no 3141 0.0731969752882156 4493 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2164 5685496 200 µM -1.45995296410828 0.0639798053280216 no 3142 0.0721515006972912 4389 759046 SGTC_1343 1487-0095 224 µM -1.4603006699147 0.0639347142682987 no 3143 0.0721037290146781 4467 4560101 YGL055W OLE1 SGTC_2467 5474540 200 µM -1.46406875326372 0.0634476467177348 no 3144 0.0715875819002609 4454 5413519 SGTC_1986 st071812 45 µM -1.47068615667808 0.0625992675341423 no 3145 0.0706880058368271 4410 11838594 SGTC_3320 9137005 35.139 µM -1.47163325937042 0.0624785717006438 no 3146 0.0705599695654381 4526 4908713 SGTC_2992 9074591 71.4286 µM -1.47958070140411 0.0614729111414623 no 3147 0.069492589930854 4418 17741321 SGTC_3165 9101544 49.47 µM -1.4822476313392 0.061138288632709 no 3148 0.0691372084917188 4480 5002184 SGTC_2526 patulin 37.61 µM -1.4870383012186 0.0605407754200654 no 3149 0.0685023476805674 4497 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1472 k841-0093 193 µM -1.48710308384487 0.0605327268696303 no 3150 0.0684937935925525 4572 X1472 SGTC_1794 st048918 76.9 µM -1.48815593860546 0.0604020382209954 no 3151 0.0683548870550442 4462 672303 SGTC_757 1066-0008 322 µM -1.49135365689941 0.0600064655812957 no 3152 0.0679343342245177 4516 6842497 SGTC_2100 5377183 190 µM -1.49426193845572 0.059648461858699 no 3153 0.0675535846041958 4520 2844202 SGTC_1138 3761-0006 1.03 µM -1.49940553330944 0.0590193955136708 no 3154 0.0668842294987204 4522 12061087 SGTC_81 0411-0046 9.971 µM -1.50034728996258 0.0589047835450967 no 3155 0.0667622328226443 4489 12925265 SGTC_2081 5214970 32.255 µM -1.50887429218687 0.0578749788933173 no 3156 0.0656654553169609 4434 2063512 SGTC_971 1315-0384 26.7 µM -1.50997241018175 0.057743394359555 no 3157 0.0655252321526572 4520 6769120 SGTC_2587 piperic acid 92.2 µM -1.5104037755516 0.0576917694009232 no 3158 0.0654702129152203 4439 5370536 SGTC_2871 9038510 12.99 µM -1.51511995514221 0.0571297110446278 no 3159 0.0648710145090198 4460 4945164 SGTC_1826 st055655 41.6 µM -1.51733585010785 0.0568671208344758 no 3160 0.0645909556323833 4505 676168 SGTC_1052 3253-3998 198 µM -1.52024680616524 0.0565236093676689 no 3161 0.0642244788289419 4455 5450317 SGTC_2059 5238311 157 µM -1.52125209347547 0.0564053595970165 no 3162 0.0640982936202467 4471 703021 SGTC_1958 st076513 41.9 µM -1.52126416693248 0.0564039406082314 no 3163 0.0640967793135253 4439 732122 YGL099W LSG1 SGTC_2295 7971645 200 µM -1.52224195655402 0.0562891147474601 no 3164 0.063974232897475 4545 2978226 YKL099C UTP11 SGTC_2134 5324836 1.464 µM -1.52433177124538 0.0560443170740773 no 3165 0.0637129272072692 4481 699272 SGTC_1310 1188-0297 994 nM -1.53414228256579 0.0549063332145103 no 3166 0.0624973265933423 4398 1588352 SGTC_275 trichlorophene 5.69 µM -1.5380789520302 0.0544548601035158 no 3167 0.062014655834905 4550 62616 SGTC_413 propylparaben 100 µM -1.5381151752507 0.0544507195534603 no 3168 0.0620102280893894 4503 7175 A pharmaceutical preservative. SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.54024922182875 0.0542072233139172 no 3169 0.0617498079976177 4558 165506 SGTC_481 bay k-8644 50 µM -1.54438387279423 0.0537379092343776 no 3170 0.0612476823025548 4488 2303 A calcium channel antagonist. SGTC_161 4065-0411 162.148 µM -1.54913337000363 0.0532027832044389 no 3171 0.0606748312728143 4503 1906281 YLR208W SEC13 SGTC_34 0469-0683 81.75 µM -1.55103656487757 0.0529895393532903 no 3172 0.0604464607885979 4500 3690923 SGTC_1387 3342-1166 1.8 µM -1.55757213927215 0.0522624161798431 no 3173 0.0596673537087394 4515 3418228 SGTC_3033 9090887 49.47 µM -1.55761175432061 0.052258033042536 no 3174 0.0596626552985767 4536 19325384 SGTC_656 4090-1979 187 µM -1.55846076551293 0.0521641658451091 no 3175 0.05956203083697 4547 22330961 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.55863204692141 0.0521452451111723 no 3176 0.0595417467662203 4497 16623 A steroid. SGTC_60 0986-0278 202 µM -1.56145167274374 0.0518345557654282 no 3177 0.059208609003087 4475 3110598 SGTC_1428 4049-0204 61.7 µM -1.56806716426596 0.0511113815112946 no 3178 0.0584327293148756 4565 X1428 SGTC_486 niguldipine 82 µM -1.57170354991279 0.0507173021042538 no 3179 0.0580096592642418 4612 1236 A calcium channel blocker. SGTC_1295 1013-0063 9.78 µM -1.57423852040031 0.0504440185307291 no 3180 0.0577161585136173 4543 6826038 SGTC_1023 4482-3888 16 µM -1.57655690656171 0.0501951123321935 no 3181 0.0574487575085399 4547 3303168 SGTC_1691 st019933 84.6 µM -1.57780080568335 0.0500619691547119 no 3182 0.0573056893473063 4529 6176082 SGTC_2104 5389443 200 µM -1.58431434887981 0.0493693709145828 no 3183 0.0565611010507291 4543 2244536 SGTC_1690 st023502 41.2 µM -1.58954532458679 0.0488187073877981 no 3184 0.0559686648768138 4549 24207482 SGTC_1555 citronellol 128 µM -1.59457929927131 0.0482934275847131 no 3185 0.0554031723776174 4513 8842 A terpine precursor. SGTC_2459 5811157 9.22 µM -1.59738302817334 0.0480028332406583 no 3186 0.055090176632379 4496 2870684 YBR192W RIM2 SGTC_1996 st072960 66.8 µM -1.59990068749196 0.0477430829439483 no 3187 0.0548103084010795 4570 1719405 SGTC_534 k292-0788 63.4 µM -1.59996948896551 0.047736000433728 no 3188 0.054802676091578 4595 4146317 SGTC_353 1988-1175 58.3 µM -1.6040380718331 0.0473186691851837 no 3189 0.0543528304437928 4371 2788357 SGTC_2251 lansoprazole 556 µM -1.6083316059472 0.0468814398852931 no 3190 0.0538812860332598 4531 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1797 st048695 56.8 µM -1.60855710844009 0.0468585658457472 no 3191 0.0538566096644124 4509 592262 YIL048W NEO1 SGTC_2912 7964298 10.93 µM -1.60958521844732 0.0467543920412919 no 3192 0.0537442186508794 4532 2975850 SGTC_1102 cgs 12066b 26.1 µM -1.61156482430694 0.0465543307339534 no 3193 0.0535283351702947 4569 6438352 A 5-HT1B full agonist. SGTC_1992 st073643 23.3 µM -1.61408655751425 0.0463004770400233 no 3194 0.0532543263597351 4564 3161292 SGTC_875 0709-0210 25.7 µM -1.61629030885272 0.0460795445530784 no 3195 0.0530157805667383 4520 6251364 SGTC_216 k038-0035 28.382 µM -1.62112801094023 0.0455975205269503 no 3196 0.0524950938829184 4491 4444231 YPR107C YTH1 SGTC_2961 9083290 32.55 µM -1.62539665402902 0.0451755713325115 no 3197 0.0520390341993384 4528 17741490 SGTC_1312 1218-2183 165 µM -1.62638851263941 0.0450779787415467 no 3198 0.0519335164947156 4608 6744073 SGTC_736 0958-0254 92.6 µM -1.62949412318884 0.0447735032818853 no 3199 0.0516042289806781 4604 6812352 SGTC_2835 9006588 71.43 µM -1.63281987535318 0.044449283551298 no 3200 0.0512534428244309 4522 2345538 SGTC_105 0111-0055 734.78 µM -1.63770474556622 0.0439765016310314 no 3201 0.0507416500964573 4568 5179370 SGTC_2713 st079149 53.4 µM -1.6395073187163 0.0438030673743046 no 3202 0.0505538238561905 4579 3103253 SGTC_1622 st003707 19.4 µM -1.6405038404227 0.0437074243110399 no 3203 0.0504502253088152 4572 10140899 SGTC_2720 fluspirilene 36.88 µM -1.64421275138766 0.0433529342248174 no 3204 0.0500661319574104 4546 3396 An atypical antipsychotic. SGTC_2913 7966556 36.57 µM -1.64490183437774 0.0432873295013733 no 3205 0.049995028293339 4477 2976516 SGTC_130 0136-0219 337.655 µM -1.64537130541959 0.0432426790493157 no 3206 0.0499466316270178 4479 234244 SGTC_1227 3909-8010 46.6 µM -1.6462773381787 0.0431566132437849 no 3207 0.0498533364755413 4563 15982272 SGTC_3158 9100007 49.47 µM -1.64670428453992 0.0431161047701945 no 3208 0.0498094215667057 4574 19297233 SGTC_3154 9100113 49.47 µM -1.64763416916949 0.0430279840387044 no 3209 0.0497138821577305 4549 25237525 SGTC_3285 9112818 20.8695 µM -1.64985951107034 0.0428176897002032 no 3210 0.0494858367887171 4557 17017947 YPR165W RHO1 SGTC_2294 7971431 200 µM -1.65706481824259 0.0421424830449914 no 3211 0.0487531855466703 4558 5741572 SGTC_2177 5811945 192 µM -1.66676357770125 0.041247249181554 no 3212 0.0477807126189039 4581 5343475 SGTC_2040 5100729 123 µM -1.66781256083634 0.0411513547324974 no 3213 0.0476764708057627 4608 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2628 lathosterol 100 µM -1.66916354624259 0.0410281186753006 no 3214 0.0475424861953389 4599 6710616 SGTC_2455 5377712 9.75 µM -1.67279091878354 0.0406987121662519 no 3215 0.0471842316189901 4575 2243908 SGTC_819 1013-0258 27.7 µM -1.67638762782422 0.0403742126367825 no 3216 0.0468311453648266 4589 5753198 SGTC_38 0929-0051 58.268 µM -1.67756098778398 0.0402688062892466 no 3217 0.046716417052828 4531 1379719 SGTC_2790 5423970 71.43 µM -1.67821979615897 0.0402097216577352 no 3218 0.0466520992717185 4578 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_3146 9095609 49.47 µM -1.68143182227739 0.039922661870945 no 3219 0.0463395343860244 4619 17173999 SGTC_2037 5169046 200 µM -1.68491845824638 0.0396129477214386 no 3220 0.0460021524049322 4634 5718022 SGTC_52 0329-0193 875 nM -1.68661053424799 0.0394633481990262 no 3221 0.045839132521848 4604 3739292 SGTC_2398 5228213 48.84 µM -1.68861628656641 0.039286611609715 no 3222 0.0456464937559958 4542 80771 YMR134W ERG29 SGTC_2219 9098279 200 µM -1.68955347590079 0.0392042523725277 no 3223 0.0455567065051128 4539 902349 SGTC_2057 5236571 38.335 µM -1.68987782721643 0.0391757814652188 no 3224 0.0455256651851425 4520 54684039 YBR257W POP4 SGTC_1945 st075991 56.6 µM -1.69160576345822 0.0390243902038856 no 3225 0.045360583429432 4570 1084980 SGTC_2091 4-phenylthiadiazole 200 µM -1.70556877674662 0.0378184364544794 no 3226 0.0440441984210496 4603 270010 SGTC_53 0973-0023 39.979 µM -1.70732338259353 0.0376690695883982 no 3227 0.0438809811731403 4515 674768 SGTC_602 3130-1533 38.1 µM -1.71083175664624 0.0373718513600967 no 3228 0.0435560876983333 4626 720941 SGTC_2719 novobiocin 32.65 µM -1.71272693678115 0.0372120963271024 no 3229 0.043381393560539 4623 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1143 3454-2408 5.08 µM -1.72088864189522 0.0365304659576323 no 3230 0.0426355165171744 4602 X1143 SGTC_3159 9100096 49.47 µM -1.72139765733862 0.0364882958549179 no 3231 0.0425893445439427 4558 25236875 SGTC_1364 1653-0028 37.6 µM -1.72311744519428 0.0363461121616603 no 3232 0.0424336443389973 4609 5718652 SGTC_1562 morin hydrate 59.1 µM -1.72680578295773 0.0360427073300379 no 3233 0.0421012747842835 4594 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1713 st033146 12.748 µM -1.72943370614874 0.035827800785185 no 3234 0.0418657509148713 4565 674619 SGTC_2775 cyproheptadine 69.59 µM -1.73584109833945 0.0353082147559107 no 3235 0.0412959674854377 4594 2913 A selective serotonin reuptake inhibitor. SGTC_849 0386-0493 241 µM -1.7429533376363 0.034738725879967 no 3236 0.0406708829992957 4624 726119 SGTC_2120 5538279 151.968 µM -1.74556357097944 0.0345316213920023 no 3237 0.0404434084937148 4605 2058197 SGTC_1214 0358-0031 63.7 µM -1.75628744120502 0.0336913716402806 no 3238 0.0395196702927592 4618 4301366 SGTC_1118 chelidonine 707.474 nM -1.75662152310918 0.0336654679040849 no 3239 0.0394911709368457 4605 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2223 6903751 107.57 µM -1.75947938250835 0.0334445469543604 no 3240 0.0392480595688834 4593 5598863 SGTC_330 1488-0319 80.1 µM -1.76857274178388 0.0327495318323036 no 3241 0.0384826014943475 4636 6846614 SGTC_1183 1254-0324 198 µM -1.77703210413804 0.0321137079298784 no 3242 0.037781478926766 4649 5799357 SGTC_1504 k297-0033 30 µM -1.78098006861153 0.031820477407998 no 3243 0.0374578534384539 4535 4388117 SGTC_2768 sulfasalazine 50.2 µM -1.78211849573449 0.0317363340783338 no 3244 0.0373649551210462 4592 5384001 An antioxidant and salicylic acid derivative. SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.7870004648996 0.0313775803455918 no 3245 0.0369687067153123 4616 442882 SGTC_542 3381-0244 89.3 µM -1.78892849252037 0.0312368250554993 no 3246 0.0368131662196962 4627 1112843 SGTC_1767 st044992 70.3 µM -1.79077610226116 0.0311024310686848 no 3247 0.0366646158326115 4628 9600693 SGTC_2517 totarol 10 µM -1.7952059649532 0.0307821532107699 no 3248 0.0363104452311842 4632 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1706 st031321 9.9705 µM -1.79874247410339 0.0305284288423499 no 3249 0.036029713404717 4652 6103185 SGTC_947 3447-0010 211 µM -1.79997495940789 0.0304404131162723 no 3250 0.0359322961161911 4578 748350 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.803083277699 0.0302193714769739 no 3251 0.0356875684796002 4638 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1788 fluconazole 20 µM -1.80796623442137 0.0298748177953584 no 3252 0.0353058779720054 4617 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_319 1348-1596 45.5 µM -1.81813794880982 0.029167534697153 no 3253 0.0345215255547843 4678 5380505 SGTC_1087 pterostilbene 9.05 µM -1.83420156145817 0.0280789281450817 no 3254 0.0333120398726314 4638 5281727 Similar to reservatol, lowers cholesterol. SGTC_1020 4335-0961 93.3 µM -1.83846069605701 0.0277960353243794 no 3255 0.0329972741811955 4608 669075 SGTC_705 1124-0212 310 µM -1.84805548066274 0.0271674400542709 no 3256 0.0322971586031172 4624 9554485 SGTC_381 3461-2219 42.7 µM -1.86286006539723 0.0262208262014944 no 3257 0.0312409782997372 4630 2883159 SGTC_43 0570-0105 72.5 µM -1.86847591067098 0.025869034552884 no 3258 0.0308478824006269 4610 1114046 YDL195W SEC31 SGTC_441 propafenone 146 µM -1.86862918203757 0.0258594888575535 no 3259 0.0308372114287281 4644 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1055 3448-0672 86 µM -1.8806551560635 0.0251196495451278 no 3260 0.0300094217768594 4623 748378 SGTC_1799 st045822 46.1415 µM -1.88088431313385 0.0251057258486434 no 3261 0.0299938287824007 4642 3674992 SGTC_615 k087-0205 167 µM -1.89031110332877 0.0245385307291717 no 3262 0.0293581823368198 4669 9642773 SGTC_878 0828-0289 13.7 µM -1.89303853364574 0.0243764455714348 no 3263 0.0291763726204661 4632 745350 YLR208W SEC13 SGTC_459 nigericin 15.3 µM -1.89498619614873 0.0242612512174573 no 3264 0.0290471152324203 4678 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1413 3910-0535 34.4 µM -1.89650878247321 0.0241715166540466 no 3265 0.0289463998902962 4679 2876951 SGTC_2885 9057732 51.95 µM -1.89861145933681 0.0240480525709315 no 3266 0.0288077903041332 4648 6471414 SGTC_834 0312-0008 75.7 µM -1.89895004980495 0.0240282209759874 no 3267 0.0287855219044082 4682 6385573 YIL048W NEO1 SGTC_2162 5663267 200 µM -1.90825285109326 0.0234886979478478 no 3268 0.0281792718487343 4666 6456493 SGTC_12 0849-0099 9.267 µM -1.91617797299581 0.0230371483872476 no 3269 0.0276712230474064 4650 6071388 SGTC_999 SEC7.066 22.7 µM -1.91811945513921 0.0229276502721175 no 3270 0.0275479330549276 4645 740511 YDR170C SEC7 SGTC_1370 2001-0092 44.6 µM -1.92751344732417 0.0224040099317986 no 3271 0.0269578369186819 4629 790957 SGTC_2302 7771753 200 µM -1.93116074993812 0.0222034381716777 no 3272 0.0267315881095264 4634 2203047 SGTC_1893 st059353 36.1 µM -1.94055071425651 0.0216940277162581 no 3273 0.0261563985672956 4660 3112488 SGTC_159 3970-0959 50 µM -1.94956556732566 0.0212142925957019 no 3274 0.025613960377683 4665 6615653 SGTC_50 0929-0078 56.389 µM -1.9549792812673 0.0209305313729152 no 3275 0.0252927578914068 4547 1377751 SGTC_2353 9059630 146.67 µM -1.95831386935974 0.0207573519700305 no 3276 0.0250965971745634 4693 4779114 SGTC_623 k072-0108 16.9 µM -1.95862265912595 0.0207413767558657 no 3277 0.0250784969710125 4662 5382803 SGTC_1914 st062367 72.6 µM -1.9661158786409 0.0203568954537847 no 3278 0.0246426133041263 4645 978205 SGTC_1676 st018489 23.4 µM -1.97492781953249 0.01991249538357 no 3279 0.0241381699180273 4634 3696235 SGTC_1139 k015-0024 46.9 µM -1.97880447930284 0.019719612320746 no 3280 0.0239190119950778 4698 2766652 SGTC_2482 5981709 142.65 µM -1.98097888184134 0.0196121209852027 no 3281 0.0237968209553404 4642 877755 SGTC_713 1488-1073 324 µM -1.99102103399154 0.0191221211514961 no 3282 0.0232392874229814 4703 3312542 SGTC_2412 st077135 33.4 µM -2.00355609052697 0.0185251217669983 no 3283 0.0225588167282416 4662 13258915 SGTC_842 0271-0008 11.1 µM -2.01933699892148 0.0177961658536925 no 3284 0.0217261024083559 4695 1221709 SGTC_2956 9076196 2.52 µM -2.02609859122325 0.0174914028263972 no 3285 0.0213773412229739 4679 16423868 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -2.0267382617347 0.0174628032596025 no 3286 0.0213445936478247 4714 368090 SGTC_2700 st077718 96.8 µM -2.03904354650123 0.0169203584489911 no 3287 0.020722840825618 4668 904970 SGTC_3312 9133330 71.43 µM -2.05341669599546 0.0163050614392191 no 3288 0.0200160907017107 4701 17617324 SGTC_237 nikkomycin 200 µM -2.05589009595548 0.0162011342835645 no 3289 0.0198965554902741 4697 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_49 0717-0965 32.132 µM -2.07362999652841 0.0154722411806762 no 3290 0.0190568435689181 4719 5889349 YGL099W LSG1 SGTC_2721 ifenprodil 61.44 µM -2.07873749387999 0.015267676885449 no 3291 0.0188207423985013 4679 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_684 1140-0066 328 µM -2.07965047593351 0.0152313561382879 no 3292 0.0187788018127176 4713 6813534 SGTC_1857 st056007 79.3 µM -2.07970043138398 0.0152293709269345 no 3293 0.0187765092550295 4696 619834 SGTC_211 3455-0679 143.504 µM -2.09131634947116 0.0147737522954425 no 3294 0.0182498575868233 4663 748649 SGTC_837 0091-0265 12.5 µM -2.09640094681172 0.0145780347901434 no 3295 0.0180233192444129 4710 759367 SGTC_2371 9071574 200 µM -2.10843721889271 0.0141236041684363 no 3296 0.0174965939472409 4722 45596039 SGTC_64 000l-0018 272.079 µM -2.11458674192084 0.0138961768422825 no 3297 0.0172325923123291 4622 6811119 SGTC_1208 2323-2347 50.3 µM -2.11602625495998 0.0138433978636285 no 3298 0.0171712873283879 4707 5412760 SGTC_2170 morpholine 200 µM -2.11723143340269 0.0137993436786154 no 3299 0.0171201054380266 4719 121171 Reacts with secondary amines. SGTC_1386 3228-0095 33.8 µM -2.12891143014084 0.0133786199851622 no 3300 0.0166307944627352 4709 870181 SGTC_2795 7780010 54.55 µM -2.12970637622826 0.0133503923145394 no 3301 0.0165979311258811 4679 953673 SGTC_2816 7982706 58.44 µM -2.13116231452114 0.0132988268856811 no 3302 0.0165378862402753 4676 2981853 SGTC_222 nsc-310342 10.666 µM -2.1326935267808 0.0132447811527679 no 3303 0.0164749376408692 4731 432556 SGTC_2446 5162541 200 µM -2.14060059385735 0.0129687027633401 no 3304 0.0161531304340837 4691 1549321 SGTC_2282 7944268 200 µM -2.15448242211356 0.0124960388366523 no 3305 0.0156011795038716 4691 2970414 SGTC_535 2293-4129 48.2 µM -2.15704852132826 0.0124103184889104 no 3306 0.0155009420116508 4699 396118 YIL048W NEO1 SGTC_2850 9015429 58.44 µM -2.16401362595787 0.012180212238399 no 3307 0.0152316518330314 4694 6457570 SGTC_2457 5731572 11.68 µM -2.17215508956061 0.0119159381389201 no 3308 0.0149219834345972 4731 2865357 SGTC_1001 4048-4355 44.4 µM -2.17610004234958 0.0117896826976607 no 3309 0.0147738903815777 4707 21824233 SGTC_2277 7947813 106.88 µM -2.18803656749244 0.0114147071733778 no 3310 0.0143334693887801 4716 1246798 SGTC_489 paxilline 115 µM -2.19729151183902 0.0111311445720437 no 3311 0.0139998167418546 4695 105008 A toxic potassium channel blocker. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -2.2174996726406 0.0105331967589239 no 3312 0.0132944826993481 4701 6857784 SGTC_599 1935-0052 86.5 µM -2.24977761727436 0.00963611748190928 no 3313 0.0122315327714291 4737 9557311 SGTC_2275 7947463 200 µM -2.26329000244047 0.00928086771842962 no 3314 0.0118089090893612 4707 1225414 SGTC_2278 7948257 134.34 µM -2.26486368998803 0.00924024888271063 no 3315 0.011760522784779 4736 1247028 SGTC_2218 6965428 192.983 µM -2.26750066786333 0.00917253392027306 no 3316 0.0116798290749439 4684 675684 SGTC_1124 fisetin 1.16336 µM -2.29519033673265 0.00848730870212391 no 3317 0.0108611093696001 4732 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3223 9129970 49.47 µM -2.2954660365557 0.0084807182785876 no 3318 0.0108532153266797 4724 17248386 SGTC_679 0422-0091 41.4 µM -2.31773090620555 0.00796309892113707 no 3319 0.0102319751218052 4752 627384 YHR062C RPP1 SGTC_3036 9090181 49.47 µM -2.35018014749366 0.00725848104968037 no 3320 0.00938216349724691 4774 25236586 SGTC_2397 5161689 200 µM -2.3630634669948 0.00699434651414874 no 3321 0.00906228268035756 4729 2259942 SGTC_1300 1094-0077 113 µM -2.3638130580979 0.00697924291630662 no 3322 0.00904396861752173 4756 5532636 SGTC_1210 3013-0140 750 nM -2.37355101702903 0.00678563221402107 no 3323 0.00880897949971142 4757 905973 SGTC_611 3453-1652 23.7 µM -2.39494322091475 0.00637688916868067 no 3324 0.00831146959940412 4742 1560575 SGTC_2456 5770359 74.46 µM -2.41106093713066 0.00608347564265311 no 3325 0.00795309529581337 4734 3118787 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -2.42566601727409 0.00582799691304957 no 3326 0.0076401625472105 4750 688669 SGTC_2373 9071805 200 µM -2.46009173005532 0.00526310417432934 no 3327 0.00694507543660839 4757 10149009 SGTC_2303 7774051 200 µM -2.47781265186531 0.00499175501691748 no 3328 0.00660952679663038 4742 2953184 SGTC_1274 0865-0114 173 µM -2.50083330486376 0.0046578947455117 no 3329 0.00619507411334842 4763 870624 SGTC_2972 9093619 59.92 µM -2.5146399139915 0.00446735732004475 no 3330 0.00595770064894128 4739 25236256 SGTC_1108 betulinic acid 729.144 nM -2.51658747237635 0.00444104797924359 no 3331 0.0059248740891025 4735 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1304 1165-0502 251 µM -2.52869708275445 0.00428054412034092 no 3332 0.00572433947486219 4769 767425 SGTC_270 tamoxifen 5.46 µM -2.55744498490449 0.00392009600779003 no 3333 0.00527221178105872 4758 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1380 2291-0730 164 µM -2.55961603783561 0.00389401223964558 no 3334 0.00523939332907217 4759 2999191 SGTC_2694 st077685 81.9 µM -2.59574586675082 0.00348217699567902 no 3335 0.00471929235625688 4713 2838096 SGTC_2818 7996756 12.99 µM -2.59723410526834 0.00346608465774477 no 3336 0.00469889244869551 4762 2241621 SGTC_1276 0871-0068 94.2 µM -2.63022606047541 0.00312607765671206 no 3337 0.00426640536033629 4770 3414906 SGTC_1435 4092-0789 56.7 µM -2.64096365467798 0.00302207789772014 no 3338 0.00413352937587083 4782 2248285 SGTC_1861 st057647 17.4 µM -2.65344226753865 0.00290513870965048 no 3339 0.00398376995089715 4771 688668 SGTC_1688 st021091 57.6 µM -2.65506777315121 0.00289021000142404 no 3340 0.00396462380439432 4793 3656366 SGTC_726 3448-4391 34.2 µM -2.66191627932217 0.00282806978945586 no 3341 0.00388486004744071 4781 1356692 SGTC_1758 st042942 75.2445 µM -2.71279397250446 0.00240289453996535 no 3342 0.00333592867948234 4767 669317 SGTC_2271 7849410 118.62 µM -2.77621319311971 0.00195424237542456 no 3343 0.00274980665836838 4749 972430 SGTC_1307 1187-1599 12.2 µM -2.82592187010268 0.00165734960923137 no 3344 0.00235723808276923 4791 1538471 SGTC_1635 st007035 42.4 µM -2.86156231044223 0.00147043728490163 no 3345 0.00210779314599704 4757 3716403 SGTC_2521 angolensin 13.4 µM -3.10504600205708 0.00062760384719332 yes 3346 0.000951247166336768 4799 821428 A flavenoid. SGTC_567 1080-0542 68.4 µM -3.15601163581573 0.000521221473665684 yes 3347 0.000799712398948458 4769 5950415 SGTC_456 gingerol 170 µM -3.24199372020193 0.000378761818121385 yes 3348 0.000593483189453325 4798 442793 A herb. SGTC_181 1447-1644 8.07 µM -3.26364185828283 0.00034909713568648 yes 3349 0.000549950528567509 4778 534600 SGTC_3130 9127414 49.47 µM -3.34674850102947 0.000254133612896288 yes 3350 0.000408826781146257 4799 1494646 SGTC_2487 5918373 44.05 µM -3.56118099874601 0.000108460017303796 yes 3351 0.000184595231859845 4799 2876279 SGTC_1527 coumarin 137 µM -3.57469584879383 0.000102632348737104 yes 3352 0.000175317632700785 4798 323 A hepatotoxic, DNA x-linker. SGTC_1634 st006576 41 µM -3.68263524673041 6.55878259918331e-05 yes 3353 0.000115417665522797 4795 3915356 SGTC_2929 9013348 24.6 µM -3.68744673192773 6.42739540665987e-05 yes 3354 0.000113257745611924 4794 2995952 SGTC_538 2922-0838 53.3 µM -3.81291314452155 3.76052962099761e-05 yes 3355 6.86691932254419e-05 4807 777039 SGTC_140 0062-0056 502.533 µM -5.45767447656908 7.45230185291275e-09 yes 3356 2.41205514750166e-08 4803 3758964