SGTCid condition conc unit YMR262W|YMR262W.score YMR262W|YMR262W.strain.pval YMR262W|YMR262W.strain.significant YMR262W|YMR262W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_264 promethazine 12.5 mM 10.1364317345495 1.66493323415543e-25 yes 1 1.90377175774663e-24 10 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_145 3737-0113 38.366 µM 8.16111683578218 3.32732170078742e-17 yes 2 1.65970444495331e-16 7 6849351 SGTC_588 3970-1144 52.9 µM 7.24329220997082 6.0833432405031e-14 yes 3 2.18960986007433e-13 3 1888707 SGTC_126 0417-1624 672.48 µM 7.23593556718369 6.43825877379505e-14 yes 4 2.31165398572349e-13 1 41912 YDL195W SEC31 SGTC_577 r071-0003 38.6 µM 6.93305504894761 6.33428047801448e-13 yes 5 2.05923921821479e-12 8 4568517 YMR134W ERG29 SGTC_2834 9001755 58.44 µM 6.52225502771452 1.21091473269547e-11 yes 6 3.462906135044e-11 8 2989575 SGTC_144 4161-2749 112.381 µM 6.48695999125036 1.5477732115708e-11 yes 7 4.37927921911775e-11 6 797501 YMR168C CEP3 SGTC_1926 methyl fluorone black 53.6 µM 6.07654114551111 2.44665881194037e-10 yes 8 6.14012526920982e-10 19 72721 Reacts with homocysteine. SGTC_3040 9091894 49.47 µM 5.92515210283569 6.4852250642409e-10 yes 9 1.56004230178955e-09 9 25236966 SGTC_585 0kpi-0023 191 µM 5.69433597492823 2.74065738911631e-09 yes 10 6.19264932190793e-09 6 64601 SGTC_112 phenothiazine 287.218 µM 5.60334476584876 4.76572509561157e-09 yes 11 1.05127211226823e-08 5 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1337 1486-1011 40.3 µM 4.91895797077863 2.33506459811019e-07 yes 12 4.35030735695525e-07 4 X1337 SGTC_219 mitoxanthrone 164.414 µM 4.53143307949651 1.71422204509801e-06 yes 13 2.92924481396117e-06 38 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1750 st081859 2.357 µM 4.37949174679669 3.59413737017127e-06 yes 14 5.94782132628332e-06 159 5291695 SGTC_2628 lathosterol 100 µM 4.36640617268093 3.82661177212136e-06 yes 15 6.31537539309826e-06 22 6710616 SGTC_2757 clomiphene 4.22 µM 4.3287031945742 4.57956600982794e-06 yes 16 7.49949547536201e-06 27 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2884 9058502 51.95 µM 4.26055306853894 6.31335644296997e-06 yes 17 1.01960826905155e-05 22 6471554 SGTC_579 4491-1009 110 µM 4.23399095994075 7.14593710519441e-06 yes 18 1.14790088420636e-05 17 1271041 SGTC_663 1486-0733 13.9 µM 3.81892799141455 4.51800702198509e-05 yes 19 6.70164388861752e-05 55 722445 YPR165W RHO1 SGTC_2906 7926292 26.41 µM 3.7305000235702 6.5454888190544e-05 yes 20 9.55500627465461e-05 31 2966319 SGTC_990 3985-0011 41.3 µM 3.69494967569454 7.58082052905887e-05 yes 21 0.000109965171333302 30 5399565 YGL099W LSG1 SGTC_569 4130-2812 160 µM 3.68772834678136 7.80915617133893e-05 yes 22 0.000113132508826678 11 743552 SGTC_2254 7938975 95.19 µM 3.59741175537122 0.000112692888178427 yes 23 0.000160699741678132 63 2969277 SGTC_257 daunorubicin 18.5 µM 3.55565772698806 0.000133153708207295 yes 24 0.00018851733405075 30 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2351 9026858 72.31 µM 3.5156498184383 0.000155983175457795 yes 25 0.000219339587342701 38 1409300 SGTC_3093 9117344 49.47 µM 3.4584416309717 0.000195054458633715 yes 26 0.000271654992264951 31 24824913 SGTC_692 k241-0027 77.8 µM 3.41240583913445 0.000232947099701542 yes 27 0.000321960842985411 21 3600480 SGTC_1515 3460-0031 42.1 µM 3.38863519026017 0.000255101920151489 yes 28 0.000351206969037217 26 2876596 SGTC_1604 st002052 72.4 µM 3.35142588247562 0.00029375934760885 yes 29 0.000401982783698592 41 6254834 YHR062C RPP1 SGTC_2977 9011197 71.43 µM 3.33165214624102 0.000316457428941037 yes 30 0.000431660470238459 31 2704722 SGTC_3294 9122953 26.2835 µM 3.33095995716669 0.000317280786895304 yes 31 0.000432735255419923 53 16459826 SGTC_768 0384-0033 77.3 µM 3.32363965818992 0.000326111089726301 yes 32 0.000444254607350587 117 3965305 YMR134W ERG29 SGTC_3337 9144342 33.5465 µM 3.32214406726761 0.000327943074436776 yes 33 0.000446642792941067 44 17682949 SGTC_2460 5552655 174.22 µM 3.28249317806965 0.000380146508494978 yes 34 0.000514467376363506 57 5401989 SGTC_347 4534-1311 26.2 µM 3.2612064864187 0.000411258524506224 yes 35 0.000554696104730121 30 2862016 SGTC_3216 9129716 49.47 µM 3.24423943715042 0.000437731458954579 yes 36 0.000588823536377976 54 8056934 SGTC_125 0133-0007 11.75 µM 3.20780413854972 0.000500003552538889 yes 37 0.000668762769715841 31 26541 SGTC_3128 9127691 49.47 µM 3.18213444851555 0.000548695277639079 yes 38 0.000730969677836912 42 41316314 SGTC_840 0245-0196 390 µM 3.16261543141974 0.000588615515627117 yes 39 0.000781793667079031 40 3827528 SGTC_1773 st048542 73.5835 µM 3.14409818656805 0.000628951540916562 yes 40 0.000832997653460131 84 3237138 SGTC_1803 st050068 52.4 µM 3.11150792303246 0.000706197040652993 yes 41 0.000930672395357643 252 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_305 1682-2595 20.8 µM 3.10991755095759 0.000710181530302357 yes 42 0.000935697864404899 50 226033 SGTC_755 1995-0008 37.3 µM 3.1058354733968 0.000720503756471976 yes 43 0.000948711277669413 48 689533 SGTC_1519 esterone 74 µM 3.10061087777649 0.000733916796301791 yes 44 0.00096560947456948 55 698 A steroid. SGTC_160 3453-0671 289.699 µM 3.06712469179026 0.00082549513525911 yes 45 0.00108064339475333 85 5322268 SGTC_3208 9114115 49.47 µM 3.05544473246355 0.000859835010640203 yes 46 0.00112363508216616 85 650895 SGTC_2710 st078562 53.7235 µM 3.05232064119576 0.000869240177109183 yes 47 0.00113539696278054 42 17250908 SGTC_1325 1431-0015 227 µM 3.03996715625203 0.000907364740769372 yes 48 0.0011830197451259 50 1103340 SGTC_1333 1482-0047 286 µM 3.03002499512712 0.000939157146714687 yes 49 0.00122266750259743 59 3811116 SGTC_2783 7738165 71.43 µM 2.99207482868862 0.00107014768700654 no 50 0.00138544167960237 70 17201110 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 2.97520513832065 0.00113358759237389 no 51 0.00146396339460498 57 165521 SGTC_2123 5259487 200 µM 2.9406402172209 0.0012744605397025 no 52 0.00163767361299402 61 2173474 SGTC_1672 st016598 6.51 µM 2.93389705930195 0.00130374283605178 no 53 0.00167367602798501 124 4665860 YNL267W PIK1 SGTC_1166 k206-0078 225 µM 2.92838947159718 0.00132811460502652 no 54 0.00170361474851536 67 5404595 SGTC_641 4092-0595 30 µM 2.92749959021747 0.00133209129188109 no 55 0.00170849755571962 53 786260 SGTC_818 4072-2707 53.5 µM 2.88723583268573 0.00152382153584434 no 56 0.00194321403644198 51 882871 SGTC_2113 5491891 107.031 µM 2.85287574834792 0.00170699165940536 no 57 0.0021662779068519 91 789979 SGTC_2593 nobiletin 86.24 µM 2.84278888416439 0.00176444844362622 no 58 0.00223603411613285 79 72344 An anti-infammatory. SGTC_1804 st050076 49.1 µM 2.83886892532344 0.00178724810454676 no 59 0.00226368749698241 69 3895976 SGTC_2376 9072922 81.32 µM 2.82799754218022 0.00185188854497813 no 60 0.00234200830759351 96 17087968 SGTC_3326 9140064 16.379 µM 2.80444318823185 0.00199928972097566 no 61 0.00252017847203466 71 1868434 SGTC_844 0330-0132 15.3 µM 2.79116225600769 0.00208702143490556 no 62 0.002625956860087 55 2828079 SGTC_1854 st056233 32.9 µM 2.7905359330891 0.00209124378340746 no 63 0.00263104294481527 70 5393174 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.78270503795949 0.00214469377653757 no 64 0.0026953895379895 76 5393153 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 2.78144770155572 0.00215339025894098 no 65 0.00270585246495684 77 5106787 A p450 inhibitor. SGTC_888 0916-0002 6.97 µM 2.77972199205119 0.00216537834622538 no 66 0.00272027266218032 98 2802138 YIL048W NEO1 SGTC_2101 5377231 179.231 µM 2.76606145705855 0.00226243076332477 no 67 0.00283689204741011 49 2844213 SGTC_378 3970-0959 8.33 µM 2.76300670950603 0.00228466550893982 no 68 0.00286357945783953 76 6615653 SGTC_2885 9057732 51.95 µM 2.76130172074002 0.00229716158263048 no 69 0.00287857312790758 67 6471414 SGTC_1119 parthenolide 318.541 nM 2.72032420090286 0.00261673374676618 no 70 0.003260896989587 138 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3129 9127257 49.47 µM 2.71661497632623 0.00264755680652501 no 71 0.00329766414029194 89 837894 SGTC_179 1273-0063 6.77 µM 2.71342014619121 0.00267436779313998 no 72 0.00332963079109589 84 3108139 SGTC_2921 7974240 10.71 µM 2.70948673770667 0.00270771355760063 no 73 0.0033693699592832 126 2979074 YDR527W RBA50 SGTC_2032 5185112 25.99 µM 2.70698992822861 0.00272907474554943 no 74 0.00339481586018249 72 5718189 SGTC_1122 capsaicin 818.572 nM 2.69620782912083 0.00282307733502675 no 75 0.00350669467486191 102 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3283 9109332 35.8195 µM 2.68746680136972 0.00290141811715146 no 76 0.00359981293862632 66 17027281 SGTC_1049 3226-0134 66 µM 2.68527324336128 0.00292138288749094 no 77 0.00362352659096826 123 5702385 SGTC_13 0199-0087 65 µM 2.68008244021692 0.00296912137564289 no 78 0.00368020151947828 64 4589825 SGTC_1468 k284-1086 134 µM 2.66771236820468 0.00308573169362465 no 79 0.00381848036943301 143 15996457 SGTC_3122 9126309 49.47 µM 2.66145193104549 0.00314630549677847 no 80 0.00389022246682298 59 17591206 SGTC_3324 9138759 60.749 µM 2.66093778289978 0.00315132746158919 no 81 0.00389616772493314 88 45595710 SGTC_106 0092-0003 11.579 µM 2.65548533267642 0.00320503016807306 no 82 0.00395971886942933 60 1072148 SGTC_1064 honokiol 6.76 µM 2.64985661469768 0.00326133143085458 no 83 0.0040262969079476 99 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2804 7954240 19.48 µM 2.64780640729663 0.00328205862858917 no 84 0.0040507952286372 120 828705 SGTC_1670 st016595 4.04 µM 2.62798848907007 0.00348860490163725 no 85 0.00429457110557292 83 597879 SGTC_1728 st035614 33.7865 µM 2.60407524897446 0.00375332822438706 no 86 0.00460612641690917 166 15945546 SGTC_433 pimozide 108 µM 2.60336605784386 0.00376144702272822 no 87 0.00461566653663572 72 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1494 4358-1428 177 µM 2.59963485953548 0.00380442159013437 no 88 0.00466615007032852 92 1564571 SGTC_1824 st053723 68.6 µM 2.5930975206508 0.00388077847713303 no 89 0.00475578978417799 114 675225 SGTC_570 0987-0065 62.6 µM 2.57554663424671 0.00409261161094692 no 90 0.00500408881378497 56 3104428 SGTC_933 2914-0560 114 µM 2.56055484619251 0.00428168972680198 no 91 0.00522525832469 118 463887 SGTC_1871 st057448 67.3 µM 2.559411362038 0.00429642709289628 no 92 0.00524247950740082 103 691747 SGTC_1762 st045503 25.4615 µM 2.5481871838817 0.00444351058460183 no 93 0.00541421759735007 119 4645554 SGTC_1919 st067113 52.3 µM 2.5461017601944 0.0044713285530698 no 94 0.00544667138962392 123 1268243 SGTC_973 1325-0077 65.9 µM 2.52507813529345 0.00476057579866582 no 95 0.00578362839338339 85 2835149 SGTC_751 0833-0568 350 µM 2.52046785534091 0.00482619289491579 no 96 0.00585994711570836 109 6954252 SGTC_2236 dapsone 200 µM 2.51087785799882 0.00496527395472063 no 97 0.00602156791005301 89 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1614 st002383 48.6 µM 2.50169401283587 0.00510180012888504 no 98 0.0061800349609947 105 1947235 SGTC_2707 st078556 66.6 µM 2.4982349927183 0.005154081711481 no 99 0.00624067124448477 73 17250899 SGTC_2068 5226020 147 µM 2.48253620844841 0.0053974029359611 no 100 0.00652254046819018 150 1810509 SGTC_1390 3413-2614 145 µM 2.48007352701654 0.00543648575099326 no 101 0.00656776464797851 131 3421432 SGTC_3310 9130229 44.1445 µM 2.47482871098451 0.0055205604284525 no 102 0.0066650045145516 125 7761258 SGTC_384 k007-0144 5.16 µM 2.43580916924598 0.00618315767366862 no 103 0.00742926046531807 184 6824886 SGTC_2840 9008771 71.43 µM 2.42383194059302 0.00640021469633539 no 104 0.00767885539642129 76 2992978 SGTC_486 niguldipine 82 µM 2.41159632713068 0.00662889027143998 no 105 0.00794142783206745 93 1236 A calcium channel blocker. SGTC_573 3702-0553 84.7 µM 2.40839251106418 0.00668994827371453 no 106 0.00801147192005443 99 1222756 SGTC_2255 7941087 197.44 µM 2.38950928674206 0.00706002297497584 no 107 0.00843544866536431 154 935561 SGTC_79 0052-0007 94.094 µM 2.38926508077642 0.00706492497878553 no 108 0.00844105831302647 133 2801472 SGTC_664 1222-0054 14.9 µM 2.38760553989339 0.00709831696380172 no 109 0.00847926637949605 152 6813991 SGTC_2247 cerulenin 830 nM 2.38434689255307 0.00716429032221883 no 110 0.00855473294769976 124 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2863 9028737 58.44 µM 2.37913913308506 0.00727084787102573 no 111 0.00867656236594832 70 6460917 SGTC_1726 st035556 14.5795 µM 2.37616270205103 0.00733237502815105 no 112 0.00874687359128609 187 5919439 SGTC_1052 3253-3998 198 µM 2.37249714119396 0.0074087778135445 no 113 0.00883414993139495 155 5450317 SGTC_1841 st054148 70 µM 2.37074591325192 0.00744552638810006 no 114 0.00887611511134264 115 675442 SGTC_1096 rimcazole 32.2 µM 2.36613702972306 0.00754300992681155 no 115 0.00898739504669338 105 18528119 A dopamine reuptake inhibitor. SGTC_1493 4348-0038 111 µM 2.34889537659325 0.00791773226909926 no 116 0.00941459835249633 169 800424 SGTC_662 k832-1615 104 µM 2.34824846978226 0.00793210503884754 no 117 0.00943096701621231 141 5878478 SGTC_3352 9151559 45.5865 µM 2.34615186856961 0.00797884446066176 no 118 0.00948418842935387 117 17159339 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 2.34400736868185 0.00802690203164194 no 119 0.00953889724017202 159 4174840 SGTC_3251 9135047 49.47 µM 2.33943762953188 0.00813015807388441 no 120 0.00965639798119123 81 17682963 SGTC_2862 9027634 71.43 µM 2.3368709786249 0.00818866351917314 no 121 0.00972294688660283 139 5012562 SGTC_1220 1838-0075 193 µM 2.32414191687676 0.00848431455508027 no 122 0.010058944553455 134 5529645 SGTC_2739 tacrine 100.86 µM 2.30994947889312 0.00882496200996128 no 123 0.0104454756469714 123 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2205 7238770 200 µM 2.30397720027453 0.00897185535393832 no 124 0.0106119617393637 99 279867 SGTC_1943 st076331 65.2 µM 2.29880922002111 0.00910069045981194 no 125 0.0107578875167887 137 24208415 SGTC_334 1502-1024 68.5 µM 2.28827470247144 0.00936833603179627 no 126 0.0110607643805198 146 3296216 SGTC_1382 3002-2117 298 µM 2.28648120611006 0.00941458204855856 no 127 0.0111130611891792 123 1497314 SGTC_1772 st048439 82.2 µM 2.28111730438453 0.00955408599912966 no 128 0.0112707532145967 183 2927068 YDL195W SEC31 SGTC_2263 7948595 193.29 µM 2.27770694012799 0.00964371928147142 no 129 0.0113720219847668 101 2971371 SGTC_338 4055-0136 114 µM 2.27234748849042 0.00978606473121096 no 130 0.0115327653348016 152 2900563 SGTC_712 r015-0009 80.6 µM 2.26740970203482 0.00991883178609206 no 131 0.0116826046803435 128 6813872 YLR060W FRS1 SGTC_2265 7929201 200 µM 2.26682130132237 0.00993475707932742 no 132 0.0117005721589037 168 1265108 SGTC_1701 st028638 40.4 µM 2.26669704459219 0.00993812298924521 no 133 0.0117043695441061 149 3490878 SGTC_1531 st059297 52.4 µM 2.26191419951614 0.0100684413270634 no 134 0.0118513524477243 154 7566702 SGTC_617 3770-0098 35 µM 2.23351988107535 0.0108732278024309 no 135 0.012757340380811 136 5962639 SGTC_460 trequinsin 123 µM 2.22925436267243 0.0109988407275543 no 136 0.012898492651305 97 5537 A vasodilator. SGTC_355 1311-2252 105 µM 2.22750406766168 0.0110507483750148 no 137 0.0129568021285437 184 5338538 SGTC_1461 k072-0203 53.8 µM 2.20935972464404 0.0116015225864635 no 138 0.0135748150277983 157 5418714 SGTC_2167 5876490 200 µM 2.20763751142596 0.0116550185187423 no 139 0.0136347760289689 188 686534 SGTC_739 1486-1183 203 µM 2.20277707102766 0.0118071516160012 no 140 0.0138052325064798 155 4346692 SGTC_3354 9151612 71.43 µM 2.19186401241222 0.0121550238371265 no 141 0.0141946636511929 156 27261949 SGTC_471 1-acyl-paf 4 µM 2.18516469319082 0.0123729481408523 no 142 0.0144383866205322 168 16759367 SGTC_2012 4023501 200 µM 2.18269080660876 0.0124542733455768 no 143 0.0145292937043197 171 3477460 SGTC_1018 4259-0013 28.1 µM 2.18258972467338 0.0124576060785186 no 144 0.0145330185805822 157 6801262 SGTC_635 k038-0028 24.7 µM 2.17671605296687 0.012652595534467 no 145 0.0147508799023639 201 4035102 SGTC_2730 imipramine 71.33 µM 2.17058713300295 0.0128588690827106 no 146 0.014981197795236 233 3696 A tricyclic antidepressant. SGTC_3286 9117135 37.221 µM 2.16452435626191 0.0130657717765212 no 147 0.0152120646966439 173 3438150 SGTC_1350 1495-0454 146 µM 2.16176984187275 0.0131607210411799 no 148 0.0153179605806027 212 1069057 SGTC_62 0180-0423 3.232 µM 2.14979088612658 0.0135806072390294 no 149 0.015785879712878 174 30102 YGL099W LSG1 SGTC_17 0960-0276 49.807 µM 2.14943409954133 0.01359328862806 no 150 0.015800002397654 213 6821114 SGTC_2604 4'-hydroxychalcone 11.32 µM 2.14308347614264 0.0138207268120455 no 151 0.0160531980185376 194 5282362 SGTC_2620 irigenin 100 µM 2.13075673519662 0.0142715704646579 no 152 0.0165545941746476 208 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1799 st045822 46.1415 µM 2.10220948370222 0.0153645566106369 no 153 0.0177674647107502 162 3674992 SGTC_1029 k015-0030 64.7 µM 2.09996191334818 0.0154535829643475 no 154 0.017866095817716 205 2208316 SGTC_2782 7736369 71.43 µM 2.09199402102997 0.015772768030914 no 155 0.0182195252741721 242 2950836 YOL077C BRX1 SGTC_795 0685-0265 78 µM 2.08986201358536 0.0158591268338189 no 156 0.0183150983737953 207 302754 SGTC_1801 st050089 28.441 µM 2.08842461025253 0.0159175786557116 no 157 0.018379774710201 324 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1818 st052136 56.3 µM 2.08649752093612 0.0159962332369121 no 158 0.0184667897655308 238 674169 SGTC_1667 st014849 34.6 µM 2.08215733113421 0.0161745999858939 no 159 0.0186640506307327 158 5348460 SGTC_2514 salinomycin 42.74 µM 2.07999827382866 0.016263962631226 no 160 0.0187628455991554 264 23682228 A polyether potassium ionophore. SGTC_9 0092-0002 10.449 µM 2.07425234417231 0.0165038476181475 no 161 0.0190279405982633 196 759368 SGTC_847 0342-0274 5.54 µM 2.07099691733873 0.0166410967279852 no 162 0.0191795420682784 187 18097 SGTC_1744 st037937 38.9 µM 2.064463588153 0.0169194913611972 no 163 0.0194868914079741 205 1016152 SGTC_143 4032-1194 15.74 µM 2.05642624630111 0.0172674285324934 no 164 0.0198707242942319 284 1806963 SGTC_1074 carmofur 3.8 µM 2.05636108632351 0.0172702741055007 no 165 0.0198738621178733 258 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1156 4092-0367 4.88 µM 2.05346417995534 0.0173971890739202 no 166 0.0200137901600079 224 1357585 SGTC_2058 5236698 133 µM 2.04853810529501 0.0176148317892467 no 167 0.0202536511627636 214 766665 SGTC_204 PMA1.184 62.41 µM 2.04336776856925 0.0178457617619893 no 168 0.0205080228165458 221 2252213 YGL008C PMA1 SGTC_276 colchicine 750 µM 2.04302822167225 0.0178610173686379 no 169 0.0205248222393909 216 2833 A microtubule depolymerizer. SGTC_649 1123-0311 367 µM 2.03888320539001 0.0180481485835824 no 170 0.0207308427266055 283 693629 YIL048W NEO1 SGTC_2055 5235184 200 µM 2.03878188398773 0.0180527436964655 no 171 0.020735900569367 223 2836034 SGTC_292 k038-0015 474 µM 2.02870842062806 0.0185146000740945 no 172 0.0212439988574417 194 46368540 SGTC_2853 9015042 58.44 µM 2.02666727487488 0.018609400100059 no 173 0.0213482256868257 182 6457456 SGTC_1267 0828-0272 9.49 µM 2.01718085890454 0.0190554331797109 no 174 0.0218383214155023 223 745334 SGTC_1884 5633444 25 µM 2.00569143330532 0.0196077862082841 no 175 0.0224445898887361 264 5724239 SGTC_665 3914-0008 307 µM 2.00528099358161 0.0196277669954374 no 176 0.0224665077764428 227 1069549 SGTC_2729 fluphenazine 10.66 µM 2.0018524490767 0.0197953497957173 no 177 0.0226503015342103 224 3372 An atypical antipsychotic. SGTC_2768 sulfasalazine 50.2 µM 2.00070595514195 0.0198516592028628 no 178 0.0227120436458753 209 5384001 An antioxidant and salicylic acid derivative. SGTC_2746 daunorubicin 9.88 µM 1.99095590118904 0.0203360441154153 no 179 0.0232428678147581 98 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2602 kawain 100 µM 1.98982432582652 0.0203929045071083 no 180 0.0233051453823231 256 5369129 SGTC_2910 7948405 25.97 µM 1.96979783921555 0.0214217215602399 no 181 0.0244307721661879 197 2971328 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.96931325762266 0.0214471499144765 no 182 0.0244585648493194 194 229346 A bile salt which induces apoptosis. SGTC_1462 k081-0014 26.5 µM 1.96920898898788 0.0214526247317659 no 183 0.0244645485389801 139 3270634 SGTC_2452 5863136 48.41 µM 1.9595529228889 0.0219647803605074 no 184 0.025024034206691 217 2184096 SGTC_1809 st050081 57.6 µM 1.95441235306559 0.0222416205080658 no 185 0.0253262354828567 227 5036894 SGTC_2213 7173844 200 µM 1.95266977681495 0.0223361308423651 no 186 0.0254293685819196 220 892728 SGTC_974 1326-0144 138 µM 1.95215979796601 0.0223638540429585 no 187 0.0254596177595531 276 5411856 SGTC_1631 benzylvanillin 81.9 µM 1.93600437100316 0.0232572284074912 no 188 0.0264335828133281 266 75506 SGTC_3205 9113483 49.47 µM 1.93263925569954 0.0234470471991049 no 189 0.0266403265064579 284 17018033 SGTC_302 1094-0063 18.9 µM 1.93251791949136 0.0234539157850988 no 190 0.0266478062368112 178 5440289 SGTC_839 0122-0028 230 µM 1.92904047451826 0.0236514872744623 no 191 0.0268629188745626 318 759448 SGTC_2520 obtusaquinone 4.71 µM 1.92863913632018 0.0236743791850361 no 192 0.026887838469672 215 5967872 SGTC_300 r073-0011 5.04 µM 1.9071427315149 0.0249280233234943 no 193 0.0282510535213632 278 2735780 SGTC_346 4513-0042 7.16 µM 1.90132248695166 0.0252768745332348 no 194 0.0286298927133252 277 2827372 SGTC_942 3253-1115 227 µM 1.89887755403175 0.0254246330687045 no 195 0.0287902885980769 259 46497897 SGTC_2776 terbinafine 19.92 µM 1.89583019573518 0.0256098110667136 no 196 0.0289912508263886 265 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3186 9110464 49.47 µM 1.89446677033116 0.0256930268621939 no 197 0.0290815405158312 212 17018021 SGTC_1116 jasmonic acid  1.58368 µM 1.88975800922851 0.0259821657127392 no 198 0.0293951659281932 253 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_500 h-89 112 µM 1.88731944394622 0.026132971138118 no 199 0.0295586863666054 274 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3199 9111318 49.47 µM 1.88433503303124 0.0263185280669814 no 200 0.0297598357608058 253 8548020 SGTC_2232 chlorophetanol 41.5365 µM 1.88358855762934 0.0263651122710207 no 201 0.0298103254008729 396 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1487 3970-0795 2.82 µM 1.88065288213272 0.0265489836731301 no 202 0.0300095765401715 253 3765103 SGTC_2226 7298446 200 µM 1.86584503063005 0.0274928562639674 no 203 0.0310315250521126 200 3283010 SGTC_1003 4049-0218 100 µM 1.86501732599899 0.0275464306107658 no 204 0.031089487836844 295 295161 SGTC_1158 4092-0494 91.8 µM 1.86434899073944 0.0275897530337469 no 205 0.0311363555868377 250 1148199 SGTC_1991 st073000 8.92 µM 1.86254089615742 0.0277072409851593 no 206 0.0312634432523053 346 4301969 YIL048W NEO1 SGTC_3194 9111903 49.47 µM 1.86195555121799 0.0277453652619635 no 207 0.0313046778886944 256 17087251 SGTC_2383 9036125 200 µM 1.86118686382922 0.0277954972550422 no 208 0.0313588963908002 199 79580 SGTC_2861 9024595 19.48 µM 1.85812868472676 0.0279956925400972 no 209 0.0315753711292962 140 16482810 SGTC_866 0495-0101 262 µM 1.85457790538371 0.0282296396545485 no 210 0.0318282628372739 237 635694 SGTC_2589 lobaric acid 100 µM 1.84986436266568 0.0285427085586383 no 211 0.0321665507095158 276 73157 A novel microtubule depolymerizer. SGTC_2149 5554786 194.827 µM 1.84844288110032 0.0286376868710885 no 212 0.0322691501084512 314 745063 YPR165W RHO1 SGTC_2069 5228469 200 µM 1.8439970992472 0.0289364361504917 no 213 0.0325917814621811 252 2835210 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.84392962651479 0.0289409900866114 no 214 0.03259669839329 284 1377 SGTC_3006 9075424 71.4286 µM 1.84358820813778 0.0289640425657604 no 215 0.0326215879086052 258 7465181 SGTC_128 0906-2981 13.371 µM 1.83848770497479 0.0293102478838687 no 216 0.0329952859709233 225 6740226 SGTC_1529 apigenin 74 µM 1.83826865923194 0.0293251926200398 no 217 0.0330114134546567 297 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1766 st045414 44.774 µM 1.83377994118273 0.0296328385168409 no 218 0.0333433332201012 307 253960 SGTC_2933 9026794 32.47 µM 1.83372061640509 0.0296369223591038 no 219 0.0333477383444092 314 17586027 SGTC_2572 astragaloside iv 100 µM 1.83364565669687 0.029642083158038 no 220 0.0333533051160613 284 45006101 An anti-inflammatory agent. SGTC_3160 9100216 49.47 µM 1.83076163513243 0.0298412082850653 no 221 0.0335680644790149 228 17191039 SGTC_680 0417-1641 114 µM 1.8271382543425 0.0300929534460536 no 222 0.0338394923914722 241 2835990 SGTC_765 1319-0117 244 µM 1.82363366428623 0.0303381179059888 no 223 0.0341037368206602 256 3487746 YGL099W LSG1 SGTC_2926 9010726 65.15 µM 1.81610675727012 0.030870261662839 no 224 0.0346769986825302 296 2994293 SGTC_3118 9124250 49.47 µM 1.81172820408785 0.0311833590621673 no 225 0.0350141017116752 246 1504786 SGTC_1400 3771-8998 51.5 µM 1.80625590387178 0.031578355395005 no 226 0.0354391881354934 221 670767 SGTC_541 4513-1321 94 µM 1.80223509170822 0.0318712097939148 no 227 0.0357542129052273 285 747515 SGTC_2736 butenafine 14.65 µM 1.80209465936247 0.0318814785412443 no 228 0.0357652569152019 324 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_860 0443-0016 25.1 µM 1.79842254652138 0.0321509636519971 no 229 0.036055036241217 276 5337942 SGTC_576 1073-0113 22.7 µM 1.79247840557818 0.0325911696802528 no 230 0.0365281826308439 436 5439563 SGTC_1171 0368-0077 21.4 µM 1.788062515487 0.032921406209823 no 231 0.0368829611823879 254 3239779 SGTC_2448 5185112 27.17 µM 1.78734969324392 0.0329749713301441 no 232 0.0369404935115668 256 5718189 SGTC_3012 9080433 71.4286 µM 1.78132445870884 0.0334306136511461 no 233 0.0374297305212433 282 17688859 SGTC_3000 9075062 71.4286 µM 1.77762580491476 0.0337128733705961 no 234 0.0377326663577381 287 17057871 SGTC_3094 9117742 49.47 µM 1.77647847048177 0.0338008287239159 no 235 0.0378270437052586 331 17149698 SGTC_249 wiskostatin 11.211 µM 1.77584437171446 0.0338495200664652 no 236 0.0378792859541208 259 2775510 A n-wasp and actin depolymerizer. SGTC_237 nikkomycin 200 µM 1.76326448716201 0.034827494186816 no 237 0.0389279459504058 307 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1506 4226-2149 212 µM 1.74645557379173 0.0361703239126717 no 238 0.0403659101854991 362 991114 SGTC_286 k060-0067 22.9 µM 1.74470985706759 0.0363121835026298 no 239 0.0405176933114447 301 5985051 SGTC_1463 k081-0032 34.1 µM 1.74404674628959 0.0363661881028666 no 240 0.0405754694427237 215 977755 SGTC_1796 st049173 110.4 µM 1.74286805486766 0.0364623445248075 no 241 0.0406783326343487 223 94134 SGTC_2866 9034245 58.44 µM 1.74184683572326 0.0365458226474436 no 242 0.0407676243982276 247 6462273 SGTC_1475 4092-1048 11.7 µM 1.73662453099557 0.0369751602955928 no 243 0.0412267333221153 349 2881759 SGTC_1787 fluconazole 80 µM 1.73223527006286 0.0373391926643388 no 244 0.0416158408311965 404 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_3028 9087778 49.47 µM 1.7288847545777 0.0376190405712957 no 245 0.0419148615638313 279 17217395 SGTC_1982 st072467 71.9 µM 1.72409051838663 0.038022449392355 no 246 0.0423457517486922 372 3163533 SGTC_1885 st057546 99.9 µM 1.72062383732188 0.0383163446829851 no 247 0.0426595525133956 339 702008 SGTC_1485 3909-9022 254 µM 1.71698184670478 0.0386270944936797 no 248 0.042991244446563 299 714516 SGTC_1706 st031321 9.9705 µM 1.71340594206185 0.0389342004752946 no 249 0.0433189419456144 286 6103185 SGTC_3258 9138477 49.47 µM 1.71330397048654 0.0389429870757675 no 250 0.0433283161618378 295 4970355 SGTC_1304 1165-0502 251 µM 1.71004865268784 0.0392243381828817 no 251 0.0436284383257977 383 767425 SGTC_2463 5473429 200 µM 1.70659094976258 0.0395249905652551 no 252 0.0439490542483973 281 5399405 SGTC_850 0388-0143 75.9 µM 1.70344801362628 0.0397998972224811 no 253 0.0442421294545867 301 67273 SGTC_78 0336-0123 156.75 µM 1.70113122354345 0.0400035360458722 no 254 0.0444591744838395 289 6765896 SGTC_2851 9015922 71.43 µM 1.69348705004002 0.0406814484342038 no 255 0.0451813988855677 343 2996893 SGTC_1907 st060210 83.7 µM 1.69061451300862 0.0409385929993513 no 256 0.0454552254926033 363 688793 SGTC_1692 fluoroquinolonic acid 71 µM 1.68501060024621 0.0414440401459566 no 257 0.0459932631823372 280 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1923 st058458 19.1 µM 1.67944817505166 0.0419507345961288 no 258 0.0465323655356726 383 3534982 SGTC_1615 st002656 86.5 µM 1.67814840780645 0.0420698534475884 no 259 0.0466590653001488 317 1584458 SGTC_2960 9079389 5.97 µM 1.67788328380128 0.0420941846647648 no 260 0.0466849432317374 346 16457355 SGTC_3298 9116858 71.43 µM 1.67596182017703 0.0422708636501566 no 261 0.0468728356586487 330 2506942 SGTC_2009 4012297 12.05 µM 1.67255718296568 0.0425853938412573 no 262 0.0472072509357994 355 45595307 SGTC_2337 9009472 200 µM 1.67246947324648 0.0425935216537646 no 263 0.0472158912916434 392 5742383 SGTC_1103 duloxetine 36.1 µM 1.6695919005067 0.0428608745637874 no 264 0.0475000669965279 391 60835 A selective serotonin reuptake inhibitor. SGTC_3343 9148379 18.9835 µM 1.65666343595669 0.0440788269789234 no 265 0.0487937696487387 331 1955036 SGTC_3020 9089140 49.47 µM 1.65535728365567 0.0442034124736212 no 266 0.0489260227280122 359 17217859 SGTC_1993 st073995 70.8 µM 1.64946054422038 0.0447694023105213 no 267 0.0495266599951754 332 3098394 SGTC_3187 9109394 49.47 µM 1.64814685903578 0.0448962859476937 no 268 0.0496612692741062 369 17098090 SGTC_820 1582-0060 59.9 µM 1.64763559610718 0.0449457449964352 no 269 0.0497137356618858 380 3848840 SGTC_2499 avocadenofuran 51.48 µM 1.6469578109237 0.0450113808399036 no 270 0.0497833589202973 381 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_107 0358-0022 2.6945 µM 1.64660044705107 0.0450460185453955 no 271 0.0498200992568385 215 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2479 5617353 43.85 µM 1.6443692252667 0.0452627664074615 no 272 0.0500499789842345 363 2731746 SGTC_2752 diclazuril 33.15 µM 1.63861580576033 0.0458255442002175 no 273 0.0506466492358593 521 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2591 skatole 100 µM 1.63217488430253 0.0464622277363298 no 274 0.051321325040712 341 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2288 7946289 167.31 µM 1.61933694235696 0.0477524276374897 no 275 0.0526873931304198 419 1246052 SGTC_2908 7930301 100 µM 1.6123352159569 0.048468092131384 no 276 0.0534445070014722 400 2223178 SGTC_1518 st038567 90.8 µM 1.60917366801811 0.0487940406492709 no 277 0.0537891862380081 313 77966 SGTC_47 0149-0135 24.25 µM 1.60798161026733 0.0489173929966588 no 278 0.0539196032166472 335 5239155 SGTC_1154 4088-0362 150 µM 1.60409631355955 0.0493211679658101 no 279 0.0543464121794159 432 6618304 SGTC_3323 9138564 53.9225 µM 1.59950725977181 0.0498015029172813 no 280 0.0548539684050348 415 43912313 YNL103W MET4 SGTC_1353 1498-1206 8.11 µM 1.59918731659878 0.0498351299474186 no 281 0.0548894938427441 441 6756808 SGTC_1399 3562-5772 25 µM 1.59506371366444 0.0502701565097234 no 282 0.0553489944065645 295 23847490 SGTC_3212 9128307 49.47 µM 1.59498593259873 0.050278391147659 no 283 0.0553576907914089 361 27243542 SGTC_349 k015-0014 24 µM 1.59374237681012 0.0504101917562795 no 284 0.0554968742854631 355 2196908 SGTC_1960 st011366 51.8 µM 1.59046863750261 0.05075848180047 no 285 0.0558646047766291 327 3972846 SGTC_1859 st055998 20 µM 1.58627853917883 0.0512070552388531 no 286 0.0563380691798189 398 676301 SGTC_2684 capsaicin 100 µM 1.58430738045146 0.0514191669163798 no 287 0.0565618935455734 351 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1697 st025554 27.742 µM 1.58196008283737 0.0516726648931572 no 288 0.0568293416647329 338 1269519 SGTC_644 1498-1197 63.3 µM 1.58002090763881 0.0518828359806366 no 289 0.0570510392522903 401 6741615 SGTC_2964 9083345 53.42 µM 1.57853693548163 0.0520441297759376 no 290 0.0572211548698862 352 17741579 SGTC_1530 rhein 70.4 µM 1.57621842980978 0.0522969266004025 no 291 0.0574877363060222 397 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1747 st037496 66.6 µM 1.56864380285433 0.0531296231777023 no 292 0.0583654799393507 421 723305 SGTC_502 l-744,832 89.3 µM 1.55900233542578 0.0542046993259359 no 293 0.0594979137030037 401 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_205 1486-1330 71.903 µM 1.55547295505505 0.0546025217894524 no 294 0.0599167353922426 310 4118834 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.55406314761045 0.0547620754369045 no 295 0.0600846773025078 464 65057 A dermal irritant. YDR527W RBA50 SGTC_2444 5485484 36.41 µM 1.54966695819354 0.055261977536284 no 296 0.0606107363335197 412 6790631 SGTC_1555 citronellol 128 µM 1.54820856250093 0.0554286093521894 no 297 0.0607860452698415 334 8842 A terpine precursor. SGTC_2711 st079103 59.1 µM 1.53138748192609 0.0573793366460492 no 298 0.0628368280227197 343 54693780 SGTC_2074 5212007 75.395 µM 1.52886467693309 0.0576765066288021 no 299 0.0631489972909127 325 758611 SGTC_2998 9066762 71.4286 µM 1.52721278978577 0.0578717429380292 no 300 0.0633540534876981 473 4945196 SGTC_1420 4'-methoxyflavone 42 µM 1.52457291363188 0.0581848276068726 no 301 0.0636828288205734 373 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2935 9038016 29.96 µM 1.52383121907571 0.0582730303170634 no 302 0.0637754393678494 431 6463195 SGTC_85 0868-0259 160.055 µM 1.52261301634811 0.0584181275167694 no 303 0.063927775673799 373 83173 SGTC_1733 st037357 54.9 µM 1.5221454922215 0.0584738884736271 no 304 0.0639863146701807 449 1272339 YGL099W LSG1 SGTC_256 clotrimazole 625 nM 1.51570187309519 0.0592466747812803 no 305 0.0647973769042732 415 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_969 1313-0238 134 µM 1.51436903305489 0.05940751810315 no 306 0.0649661343858177 464 5212874 SGTC_3089 9117425 49.47 µM 1.50608303166735 0.0604151402437358 no 307 0.0660229299823933 405 9401657 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.50354781905473 0.0607260930775318 no 308 0.0663489177495454 409 75037 A free radical scavenger. SGTC_202 3594-0513 34.79 µM 1.50247770036646 0.0608577220303522 no 309 0.0664868913952635 366 708429 SGTC_1449 4112-4002 201 µM 1.49834904824528 0.0613676547608926 no 310 0.0670212934559841 406 2059539 SGTC_1329 1447-1697 50.6 µM 1.4981115651742 0.0613970876778106 no 311 0.0670521334015923 440 2840515 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.48986495281298 0.0624260032366979 no 312 0.068129874194704 435 688798 SGTC_730 1436-0052 41.2 µM 1.48934900461679 0.0624908214297667 no 313 0.0681977448231526 370 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1004 4084-0029 199 µM 1.48927733263095 0.0624998296780081 no 314 0.0682071770722027 469 716894 YLR208W SEC13 SGTC_293 4049-0273 38.5 µM 1.4794195515698 0.0637484998258514 no 315 0.0695141089194537 382 1380311 SGTC_167 3672-0051 66.205 µM 1.47257888221559 0.0646263426123335 no 316 0.0704323112640169 412 3237971 SGTC_981 1488-1094 54.9 µM 1.46972918537914 0.0649947943736844 no 317 0.0708175574829613 377 3449522 SGTC_2819 7996655 46.38 µM 1.46700613964498 0.0653483922024426 no 318 0.0711871925877938 387 6456960 SGTC_1215 3852-0577 11.2 µM 1.46459688433323 0.065662485747386 no 319 0.0715154662799559 492 2884876 SGTC_813 k007-0158 173 µM 1.46422948441313 0.0657104861918042 no 320 0.0715656283638935 509 6523916 SGTC_1218 1348-1416 30.7 µM 1.46023890481748 0.0662336054088021 no 321 0.0721122132177812 453 6787668 SGTC_2308 7584454 197.62 µM 1.458458525399 0.0664680307301565 no 322 0.0723570995265199 495 893577 SGTC_3125 9127534 49.47 µM 1.45281169476923 0.0672158085971423 no 323 0.0731380220027714 328 1639235 SGTC_1676 st018489 23.4 µM 1.45247056528794 0.0672611899415372 no 324 0.0731854039104644 469 3696235 SGTC_3234 9132280 49.47 µM 1.45136227846483 0.0674087917307299 no 325 0.0733395038846606 472 17612295 SGTC_3103 9120822 49.47 µM 1.44711987316659 0.0679761100327657 no 326 0.073931676468238 471 17141819 SGTC_175 3793-3120 23.7 µM 1.44450656728971 0.068327406578691 no 327 0.0742982668730097 410 5322297 SGTC_1177 0983-0204 23.6 µM 1.44166831347187 0.0687105272346149 no 328 0.0746979833303222 483 766818 SGTC_3217 9129673 49.47 µM 1.43251907170374 0.0699568163849189 no 329 0.0759976619919066 455 17248312 SGTC_1256 0570-0116 285 µM 1.43214117948007 0.0700086636190167 no 330 0.0760517107037497 435 410638 SGTC_2129 girgensonine 121.053 µM 1.43150374073615 0.0700961879135965 no 331 0.0761429478290934 516 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2958 9077254 16.72 µM 1.42907352465901 0.0704306440081227 no 332 0.0764915510563238 421 16457351 SGTC_2395 5646831 180.19 µM 1.42223671663479 0.0713781343799907 no 333 0.0774787715918331 458 6808628 SGTC_174 3553-0389 74.3 µM 1.42186540964271 0.0714298713183741 no 334 0.077532663268916 418 738071 SGTC_1952 st077036 64.1 µM 1.41516325615846 0.072368687464893 no 335 0.078510317513305 498 2937007 SGTC_1613 st002381 52.1 µM 1.40860619550717 0.0732963006900387 no 336 0.0794758229347425 466 551167 SGTC_2543 pimpinellin 60.67 µM 1.40697505209112 0.0735284617308917 no 337 0.079717393321102 450 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_461 N-acetylfarnesylcysteine 136 µM 1.40448152140529 0.0738844528153647 no 338 0.080087755223736 398 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1829 berberine 14.4 µM 1.40288417943664 0.0741131899018488 no 339 0.0803256896355001 464 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_702 1488-0190 94 µM 1.39936779150241 0.0746186373210242 no 340 0.0808513601068669 453 949357 SGTC_1211 1056-0033 32.3 µM 1.39187494145562 0.0757044338906679 no 341 0.0819801356141614 494 6741922 SGTC_2643 anethole 100 µM 1.39150876636771 0.0757578035478506 no 342 0.0820356016000042 506 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2953 9074162 66.49 µM 1.38751362456242 0.07634195495205 no 343 0.0826425997588691 439 16451992 SGTC_3170 9103054 49.47 µM 1.38662344980529 0.0764725779388274 no 344 0.0827783069737974 444 16432970 SGTC_891 0929-0073 133 µM 1.38385330427981 0.0768801530677306 no 345 0.0832016887067502 472 5603632 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.38213714810725 0.077133480519148 no 346 0.0834647970677975 474 6708760 SGTC_41 0478-0632 82.643 µM 1.37499925195468 0.0781939380098092 no 347 0.0845658383075944 581 3750424 SGTC_2878 9043973 25.97 µM 1.37491389829036 0.0782066853389691 no 348 0.0845790699624857 461 6465167 SGTC_2307 7538926 6.34 µM 1.36972667939527 0.0789843439430815 no 349 0.0853861186061739 524 96582 SGTC_2923 7992654 58.14 µM 1.36860555126974 0.0791531886217862 no 350 0.0855613039111364 490 2985126 SGTC_1775 st081588 35.1725 µM 1.36777293949748 0.0792787587728941 no 351 0.0856915802737425 547 1426443 YGL099W LSG1 SGTC_674 0498-0004 451 µM 1.36506243038544 0.0796885882329822 no 352 0.0861167144584521 495 4231473 SGTC_2352 9027995 87.8 µM 1.36168517104882 0.0802014705803263 no 353 0.0866486315462004 437 2997347 SGTC_1082 camptothecin 424.86 nM 1.36061719925312 0.0803641746238012 no 354 0.0868173467052502 449 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_764 1951-2361 146 µM 1.36023390566659 0.0804226296576635 no 355 0.0868779581583406 522 5438930 SGTC_2049 5262831 67.185 µM 1.35751006043682 0.0808389613382402 no 356 0.0873095995120632 508 763417 SGTC_2639 lactacystin 53 µM 1.35711969924367 0.080898759959816 no 357 0.0873715900697095 542 3870 A proteasome inhibitor. SGTC_65 0798-0905 34.986 µM 1.35645507055415 0.081000649870003 no 358 0.0874772107302782 620 3602145 SGTC_80 0159-0065 512.242 µM 1.35068790627774 0.0818888467018143 no 359 0.0883977139621877 363 1548079 SGTC_1135 dihydrocapsaicin 536.708 nM 1.34745658517523 0.0823896979517609 no 360 0.0889166134524898 526 107982 A Capsaicinoid. SGTC_318 1488-0629 67.2 µM 1.34679651952307 0.0824922905195754 no 361 0.0890228879993726 482 3662576 SGTC_3185 9108267 49.47 µM 1.34490315245382 0.0827871060197503 no 362 0.0893282560396623 527 4910486 SGTC_2740 felodipine 17.08 µM 1.34326992656642 0.0830420513168431 no 363 0.0895922931475985 423 3333 L-type calcium channel blocker SGTC_2001 4023502 57.655 µM 1.3431210302166 0.0830653232600467 no 364 0.0896163934610346 541 108941 YCR052W RSC6 SGTC_997 3996-0078 137 µM 1.34084097480149 0.0834223002821973 no 365 0.0899860447730194 543 735687 SGTC_3032 9089427 49.47 µM 1.33975002923986 0.0835935115458045 no 366 0.0901633132809094 473 17173707 SGTC_3098 9119039 49.47 µM 1.33751165510563 0.0839456248243183 no 367 0.0905278402050538 514 17161528 SGTC_2401 5128683 200 µM 1.33694860294638 0.0840343722798432 no 368 0.0906197071736673 486 708373 SGTC_138 0850-0259 40.9225 µM 1.3363093281485 0.084135219209055 no 369 0.0907240944078456 668 6813004 SGTC_68 0986-0284 82.829 µM 1.33409979576373 0.0844844772260904 no 370 0.091085576389261 489 423278 YIL048W NEO1 SGTC_2469 5655019 90.81 µM 1.332444819665 0.0847467888639352 no 371 0.0913570312530849 542 2788239 SGTC_1452 4194-0072 190 µM 1.3282316421066 0.0854173280887751 no 372 0.0920507971215937 588 1343545 SGTC_2449 5812982 45.77 µM 1.32717615514497 0.0855859326581636 no 373 0.0922252091004841 483 776185 SGTC_222 nsc-310342 10.666 µM 1.32481182927211 0.0859645166381321 no 374 0.0926167851807876 385 432556 SGTC_3002 9075603 71.4286 µM 1.32362069346271 0.0861557194381251 no 375 0.0928145245310171 548 20105405 SGTC_1947 st076332 61.6 µM 1.32333164431508 0.0862021659450629 no 376 0.0928625563467585 445 24208416 SGTC_69 0096-0274 206.684 µM 1.31599217209104 0.087387809573884 no 377 0.0940883350168042 610 6741392 SGTC_1769 st044406 64.4 µM 1.31264939167939 0.0879318310737159 no 378 0.0946505590718391 583 670903 SGTC_2194 5927483 104.545 µM 1.31003288572237 0.088359413986478 no 379 0.0950923554016365 581 760979 SGTC_485 niflumic acid 177 µM 1.3088443669004 0.0885541497445217 no 380 0.0952935373821688 498 4488 A COX2 inhibitor. SGTC_447 ml7 120 µM 1.30520364531531 0.0891526622103936 no 381 0.0959117566274453 542 4216 Selective myosin light chain kinase inhibitor. SGTC_729 4092-0585 94.1 µM 1.3042361895999 0.0893122111380431 no 382 0.0960765321559463 498 2169061 SGTC_890 0929-0006 47.2 µM 1.30062037152075 0.0899103981413367 no 383 0.0966942152563329 521 1378169 SGTC_1328 1441-0025 69.2 µM 1.29917433425894 0.090150456678956 no 384 0.0969420537091892 490 4562601 SGTC_2891 9063876 19.48 µM 1.29806936456775 0.0903342148340992 no 385 0.0971317501913632 468 6472478 SGTC_150 3970-0969 77.2 µM 1.2965033308036 0.0905951249310619 no 386 0.0974010666299105 636 6615640 SGTC_2061 5245884 80.95 µM 1.29550827108665 0.0907611979064826 no 387 0.0975724749812389 569 573863 SGTC_1575 cyproterone acetate 48 µM 1.29543410900321 0.0907735844128855 no 388 0.0975852589466019 538 9880 An androgen receptor antagonist and liver toxin. SGTC_750 4073-0104 132 µM 1.29317000278158 0.0911523380386785 no 389 0.0979761340424419 446 22330957 SGTC_166 k072-0058 166.424 µM 1.29193371694442 0.091359645593172 no 390 0.0981900500019719 552 5846229 SGTC_960 1222-0186 7.7 µM 1.29176311718072 0.0913882801689276 no 391 0.0982195959186623 567 3126296 SGTC_1649 st011737 51.3 µM 1.2874452779287 0.0921152311314829 no 392 0.098969565668134 539 1761035 SGTC_2130 NSC 7 2.4545 µM 1.28365925529556 0.0927561605026445 no 393 0.099630603353812 598 21448 SGTC_2391 6285546 200 µM 1.27734340679483 0.0938326897776042 no 394 0.100740517659337 584 846083 SGTC_708 3448-5400 146 µM 1.27652243814297 0.0939732975075121 no 395 0.100885450079525 596 3462195 SGTC_1770 st043884 66.3 µM 1.27636323343461 0.0940005825716249 no 396 0.10091357340047 564 670149 SGTC_2627 acetyl isogambogic acid 100 µM 1.27047342609858 0.0950141112913979 no 397 0.101958021415664 536 6857789 A caspase activator and apoptosis inducer. SGTC_404 fumagillin 50 µM 1.26811197204508 0.0954227274513238 no 398 0.102378983371529 594 12015870 A methionine aminopeptidase binder. SGTC_2161 5662504 8.5105 µM 1.26226761334889 0.0964395703543838 no 399 0.103426253170646 555 2859334 SGTC_1318 1280-3875 124 µM 1.26112452305792 0.0966393808061373 no 400 0.10363199326003 610 373245 SGTC_2201 6605497 169.863 µM 1.26066450942823 0.0967198762434313 no 401 0.103714872955176 533 670741 SGTC_2659 sanguinarine 24.21 µM 1.2604690141611 0.0967540998686376 no 402 0.10375010948619 572 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_274 sirtinol 40.1 µM 1.25720293090733 0.0973271801534354 no 403 0.104340081138047 565 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_3152 9099253 49.47 µM 1.25311188544225 0.0980485199184327 no 404 0.105082495583999 687 25236131 SGTC_387 norethindrone acetate 66.7 µM 1.25263264100563 0.0981332767296649 no 405 0.105169715071948 529 541197 SGTC_1488 4013-0813 75.9 µM 1.24992022548456 0.0986139929648172 no 406 0.10566434513563 522 2910057 SGTC_1668 st014914 51.6 µM 1.24755802724171 0.0990340432112075 no 407 0.106096478743241 553 2839556 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.24610104354333 0.0992937783307405 no 408 0.106363650888204 569 6710655 SGTC_3300 9124615 50.48 µM 1.24374824807657 0.0997142599247408 no 409 0.106796116307261 579 24824903 SGTC_609 0986-0026 86.3 µM 1.24222520601987 0.0999871442666524 no 410 0.107076741090075 607 2848610 SGTC_1354 1498-1681 81 µM 1.24166855590115 0.100087015555238 no 411 0.107179438031585 622 5754243 SGTC_203 k066-0004 30.888 µM 1.24116440493337 0.100177530554053 no 412 0.107272510628077 690 6795412 SGTC_1001 4048-4355 44.4 µM 1.23985148839195 0.10041353131302 no 413 0.107515164936556 577 21824233 SGTC_716 1683-5115 658 µM 1.23953778160405 0.100469981067964 no 414 0.107573202986452 674 723597 SGTC_621 3584-0052 32.1 µM 1.2386229077195 0.100634739649777 no 415 0.107742590261206 614 2273927 SGTC_1290 0986-0249 10.2 µM 1.23849662869156 0.100657496563912 no 416 0.107765985681364 542 53329 SGTC_21 0849-0113 22.993 µM 1.23669518070921 0.10098254673948 no 417 0.108100134273994 604 1560156 SGTC_3164 9100705 49.47 µM 1.23148268118291 0.101927390164523 no 418 0.109071195080932 519 17174235 SGTC_1651 st011928 86.1 µM 1.2302014692156 0.102160610903281 no 419 0.109310834926642 605 720198 SGTC_3065 9113888 49.47 µM 1.23001064905668 0.10219537934196 no 420 0.10934655855817 544 16648368 SGTC_2666 tannic acid 100 µM 1.22909292291385 0.102362714130964 no 421 0.109518484139121 640 16134267 A thiamine antagonist. SGTC_1971 st069429 63.5 µM 1.22847648224632 0.10247522545638 no 422 0.109634076240806 558 1246522 YGL099W LSG1 SGTC_1969 st069479 40.1 µM 1.22294711184924 0.10348845580532 no 423 0.11067483639001 544 3895485 SGTC_2703 st077852 53.4 µM 1.22286007620036 0.103504462586508 no 424 0.110691274997094 564 6281836 SGTC_1705 st027868 56.3335 µM 1.22277992490683 0.103519204850772 no 425 0.110706414888993 578 292948 SGTC_2612 dictamnine 15.46 µM 1.22109736948588 0.103829029885106 no 426 0.111024577782967 588 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_724 3910-0327 137 µM 1.21882443897108 0.10424863357961 no 427 0.111455416804989 618 2885483 SGTC_2362 9071156 126 µM 1.21526847163594 0.104907560980146 no 428 0.1121318563599 596 653133 SGTC_423 5-fluorouracil 457 µM 1.21470668621792 0.105011936075815 no 429 0.112238990749408 594 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2890 9046729 58.44 µM 1.21382591011661 0.105175728283262 no 430 0.112407104966628 539 903329 SGTC_2211 7117706 200 µM 1.21035598221 0.10582280699724 no 431 0.113071162350883 579 822771 SGTC_2531 methyl deoxycholate 70.07 µM 1.2077526542223 0.106310166384164 no 432 0.11357120896674 581 16667744 Haematoxylin. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.2074471318024 0.106367468212036 no 433 0.113629996856735 658 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3119 9125183 49.47 µM 1.20689219507784 0.106471605629684 no 434 0.113736831929784 473 22695334 SGTC_939 1165-0479 45.3 µM 1.20466508932595 0.106890276721905 no 435 0.114166309125902 622 1377347 SGTC_335 4077-0256 27.6 µM 1.20359467342914 0.107091925084508 no 436 0.114373139631269 701 3121989 SGTC_769 0302-0231 76 µM 1.19928049232244 0.107907425328263 no 437 0.115209448901502 718 571869 YER009W NTF2 SGTC_2888 9058547 12.99 µM 1.19872720297236 0.108012335102122 no 438 0.115317018434899 521 16476514 SGTC_3237 9133362 49.47 µM 1.19498922979639 0.108723020557286 no 439 0.116045619054854 612 43845137 SGTC_1010 4112-3296 15.2 µM 1.19451550758651 0.108813326943728 no 440 0.116138189132545 663 704384 SGTC_1406 3909-7906 11.9 µM 1.19350834274698 0.109005503509102 no 441 0.116335173390968 634 X1406 SGTC_2828 7998861 71.43 µM 1.19300966766199 0.109100745672418 no 442 0.116432793420777 528 2988188 SGTC_1433 4060-0023 7.6 µM 1.19096363960136 0.10949214346946 no 443 0.116833929656784 644 3840627 SGTC_3261 9137475 49.47 µM 1.18674241401036 0.11030283281411 no 444 0.117664619758601 405 17027690 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.1854293911261 0.110555875298395 no 445 0.117923858369456 623 390807 SGTC_540 1187-0821 17.3 µM 1.18460426380269 0.110715104524727 no 446 0.118086975207757 605 847520 SGTC_2900 5328528 85.29 µM 1.18398337090678 0.110835029854273 no 447 0.118209822756688 677 795359 SGTC_2948 9070189 9.45 µM 1.18201042994953 0.111216720628553 no 448 0.118600781202866 565 6473636 YDL196W YDL196W SGTC_1210 3013-0140 750 nM 1.18132824173686 0.111348917414144 no 449 0.118736176124892 675 905973 SGTC_678 1218-2179 85.9 µM 1.18063751099679 0.111482884160537 no 450 0.118873377711346 589 6820081 YOR116C RPO31 SGTC_2480 5767542 37.17 µM 1.1803413432817 0.111540361000243 no 451 0.118932240535546 653 2867358 SGTC_1266 0828-0227 32.9 µM 1.17710097397321 0.112170600260425 no 452 0.119577603206062 597 3913820 SGTC_2430 5571206 200 µM 1.17633813873097 0.112319338172861 no 453 0.119729890540236 716 1731771 SGTC_2368 9071271 200 µM 1.1760009326624 0.112385131642178 no 454 0.11979725168087 618 27209959 SGTC_2791 5663188 71.43 µM 1.17441439953633 0.112695055291315 no 455 0.120114540185211 597 54690634 SGTC_810 3825-7150 143 µM 1.17377262755928 0.112820596399191 no 456 0.120243055329101 688 22330411 YGL099W LSG1 SGTC_556 4058-0063 51.5 µM 1.17105995455813 0.11335234255293 no 457 0.120787339442016 695 6615692 SGTC_116 0155-0182 31.788 µM 1.16392393928918 0.114759695145462 no 458 0.122227418551171 778 771486 SGTC_1460 k062-0059 9.15 µM 1.16282954073627 0.114976625282874 no 459 0.122449334563941 631 1373085 SGTC_733 4069-0007 56.1 µM 1.16096008437858 0.115347860568907 no 460 0.122829066164865 720 5717425 YNL287W SEC21 SGTC_519 k048-0011 62.8 µM 1.15958511798567 0.115621443565575 no 461 0.123108881483101 631 6836379 SGTC_1730 st033808 45.1 µM 1.1566167530522 0.116213642955467 no 462 0.12371448726919 739 1045166 SGTC_2767 sibutramine 71.45 µM 1.15311091347421 0.116915838881512 no 463 0.124432431367865 666 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_956 1185-0240 191 µM 1.15203380077901 0.117132179899212 no 464 0.124653591998559 642 1416193 SGTC_2820 7989630 71.43 µM 1.15170291867174 0.117198695380328 no 465 0.124721586255833 537 2984098 SGTC_1307 1187-1599 12.2 µM 1.15164746293243 0.117209845972037 no 466 0.1247329846081 658 1538471 SGTC_1495 4469-0029 237 µM 1.14972368257969 0.117597129493601 no 467 0.125128848456921 772 793680 SGTC_399 oxolinic acid 75 µM 1.14940119702194 0.117662138834939 no 468 0.125195293349409 641 4628 A DNA gyrase inhibitor. SGTC_2716 st080858 38.6235 µM 1.14760268221247 0.118025165052231 no 469 0.125566311006457 670 5296050 SGTC_1221 2958-7315 257 µM 1.14544054327422 0.118462635823065 no 470 0.126013355837931 646 4562705 SGTC_3312 9133330 71.43 µM 1.1447828774413 0.118595929969885 no 471 0.126149554968119 713 17617324 SGTC_2135 5326629 150.42 µM 1.14448703003931 0.118655926165679 no 472 0.126210856857654 603 5020077 SGTC_1503 4585-0012 61.3 µM 1.14277403361174 0.119003733808878 no 473 0.126566211228963 649 2922052 SGTC_1878 temozolomide 1 mM 1.14052092309125 0.119462301746372 no 474 0.127034670443555 636 5394 DNA alkylating agent. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.14010913072336 0.119546247018427 no 475 0.127120419197056 769 688664 SGTC_1081 sertraline 6 µM 1.13989763987114 0.119589376316288 no 476 0.127164474219103 696 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2087 5276107 200 µM 1.13803037813382 0.119970642993773 no 477 0.127553898843685 672 144405 SGTC_2536 dehydroabietamide 32.04 µM 1.13774674317611 0.120028631848631 no 478 0.12761312447033 715 3983547 SGTC_1612 st002233 45.4 µM 1.13357419535732 0.120883988288879 no 479 0.128486601159199 675 1035021 SGTC_2077 5212015 200 µM 1.13349333132346 0.120900607372298 no 480 0.128503570041613 637 780900 SGTC_1224 0823-0416 294 µM 1.1283913155009 0.121952420378829 no 481 0.129577346914299 697 3598164 SGTC_1352 1496-0991 99 µM 1.12647525752377 0.122349083178024 no 482 0.129982203873689 686 3000039 SGTC_217 ketoconazole 989 nM 1.12531759027068 0.122589182130833 no 483 0.13022723919621 662 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_917 harmaline 728.087 nM 1.12477678296602 0.122701458196277 no 484 0.130341817551629 684 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_35 0133-0054 64.071 µM 1.12454424581967 0.122749756997394 no 485 0.130391105559951 633 99677 SGTC_2141 5621638 7.665 µM 1.12434439746905 0.122791276871225 no 486 0.130433475230246 678 2856238 SGTC_3329 9141233 27.5565 µM 1.12269713910316 0.123133881351478 no 487 0.130783071728237 657 4909101 YNL103W MET4 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.11993245873398 0.123710397253102 no 488 0.131371272546967 785 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_3203 9113543 49.47 µM 1.11955553661527 0.123789142581647 no 489 0.13145160604882 645 17018012 SGTC_964 1287-0107 19.4 µM 1.11789510121283 0.124136453019693 no 490 0.131805898768673 737 51516812 YPR165W RHO1 SGTC_814 3342-0569 96 µM 1.11424333106564 0.124902684371341 no 491 0.132587405416647 724 4346283 SGTC_743 1275-0778 158 µM 1.11421847828902 0.124907910391775 no 492 0.13259273501401 734 2849257 YMR203W TOM40 SGTC_1974 st069448 26.9 µM 1.11072099917954 0.125644881224677 no 493 0.133344230243829 670 6323587 YNR016C ACC1 SGTC_3162 9099653 49.47 µM 1.11044171351884 0.125703861393915 no 494 0.133404365790444 643 25237511 SGTC_1165 k072-0275 30.3 µM 1.11006642675383 0.125783145701645 no 495 0.133485201584117 688 6153523 YGL055W OLE1 SGTC_3161 9100388 49.47 µM 1.10743689481918 0.126339647658389 no 496 0.134052540890065 711 25236368 SGTC_878 0828-0289 13.7 µM 1.10447185393978 0.126969210494226 no 497 0.13469425321296 730 745350 YLR208W SEC13 SGTC_1072 oxiconazole 14.9 nM 1.09731020258328 0.128498829830004 no 498 0.13625290620633 744 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2794 7785382 27.27 µM 1.09681581551676 0.128604893314699 no 499 0.136360957557921 800 2205081 SGTC_1669 st015249 58.4 µM 1.09644160750871 0.128685214532387 no 500 0.136442782001201 712 722793 SGTC_2980 9014342 25.29 µM 1.09589502737716 0.1288025968002 no 501 0.136562357732206 671 2996599 SGTC_1349 flufenamic acid 69 µM 1.09478145170697 0.129041975467082 no 502 0.136806197175413 686 3371 A non-steroidal anti-inflammatory. SGTC_2779 methotrexate 400 µM 1.09308599361907 0.129407029984526 no 503 0.137178022518883 750 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_3111 9122088 49.47 µM 1.08963678443475 0.130151897482247 no 504 0.137936586374986 587 16876704 SGTC_3221 9128209 49.47 µM 1.08659305009486 0.130811661252714 no 505 0.138608348933839 681 16460723 SGTC_633 0437-0093 97.7 µM 1.08615428155636 0.130906959579861 no 506 0.138705370144793 702 2831118 SGTC_598 3937-0236 20.2 µM 1.08266507813359 0.131666504853616 no 507 0.139478554971171 777 1379313 SGTC_2847 9005661 71.43 µM 1.08241241176949 0.131721624234078 no 508 0.139534657803565 607 2991449 SGTC_2852 9023854 51.95 µM 1.08161090556655 0.131896578841752 no 509 0.139712728308642 724 19798528 SGTC_561 1550-0330 72.9 µM 1.08048409183757 0.13214281329787 no 510 0.139963333522681 691 6812934 SGTC_809 3998-0021 90 µM 1.08044117194492 0.13215219853364 no 511 0.1399728850124 694 715485 SGTC_154 3389-1638 511.116 µM 1.07968775088156 0.132317022959856 no 512 0.140140625170309 632 5238686 SGTC_655 k060-0012 42 µM 1.07952499870928 0.132352646530825 no 513 0.140176877916414 711 5994525 SGTC_2996 9066192 71.4286 µM 1.07946714179339 0.132365311978531 no 514 0.140189766972412 699 6472854 SGTC_1712 st032288 53.4 µM 1.07921773156687 0.132419919890938 no 515 0.1402453384711 844 2883011 SGTC_578 3460-0051 92 µM 1.07902427221643 0.132462288151759 no 516 0.140288453766415 823 2876744 SGTC_2257 7960413 200 µM 1.07892430375166 0.132484185248386 no 517 0.140310736753889 772 2974689 YIL048W NEO1 SGTC_1850 st056238 17 µM 1.07867675367917 0.132538419361364 no 518 0.140365926051546 768 5393177 SGTC_1729 st035615 45.989 µM 1.07747675822472 0.132801535232804 no 519 0.140633664289321 693 17385451 SGTC_1662 st014054 52 µM 1.07557022462802 0.133220308847682 no 520 0.141059754922846 702 2838777 SGTC_2252 omeprazole 400 µM 1.07508065086306 0.133327991098032 no 521 0.141169310745462 635 4594 A proton pump inhibitor. SGTC_3144 9087057 49.47 µM 1.07486936381581 0.133374482393509 no 522 0.141216609948978 708 17249618 SGTC_120 rhodamine 6G 52.259 µM 1.07413069317314 0.133537106052101 no 523 0.141382054889955 868 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1481 3346-2004 36 µM 1.07195013963458 0.13401796582564 no 524 0.141871213928843 750 2770522 SGTC_319 1348-1596 45.5 µM 1.07035273069866 0.134370983612736 no 525 0.142230283788406 775 5380505 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.06849024881701 0.134783386519331 no 526 0.142649713327767 773 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_428 3448-4153 16.5 µM 1.06810074627806 0.134869742401795 no 527 0.142737534640799 644 3834874 SGTC_1572 epiandrosterone 68.9 µM 1.06559020043938 0.135427261566709 no 528 0.143304465494508 782 441302 A steroid. SGTC_951 1171-0579 82.7 µM 1.06549520609881 0.135448388011776 no 529 0.143325946909825 800 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_87 0100-0052 35.5 µM 1.06402226425312 0.135776254705778 no 530 0.143659306858221 946 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1984 st072354 53.1 µM 1.06226163172929 0.136168871985913 no 531 0.144058463727152 733 5762938 SGTC_223 busulfan 5 mM 1.06105640136382 0.136438083338546 no 532 0.144332134970197 654 2478 A DNA alkylator. SGTC_3015 9080845 49.47 µM 1.0606833427984 0.136521486872618 no 533 0.144416916223087 786 5296973 SGTC_3327 9140648 26.9345 µM 1.05964960225785 0.136752779159636 no 534 0.144652019311783 719 8029710 SGTC_3114 9122766 49.47 µM 1.05907699881666 0.136881010438154 no 535 0.144782357115402 684 17176985 SGTC_3058 9093861 49.47 µM 1.0586217986763 0.136983008532585 no 536 0.144886027618936 720 17217477 SGTC_1277 0873-0036 22 µM 1.05715170566894 0.137312771452214 no 537 0.14522117830351 775 5965735 SGTC_228 caffeine 993.056 µM 1.05581312001531 0.137613506589926 no 538 0.145526801446563 698 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1480 1070-0044 41.2 µM 1.05232470895992 0.1383993463122 no 539 0.146325299485245 758 3124987 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.05135239300265 0.138618925401031 no 540 0.1465483861022 712 364106 SGTC_2795 7780010 54.55 µM 1.04906587869274 0.139136226136728 no 541 0.147073899495214 703 953673 SGTC_2881 9058953 51.95 µM 1.04841694897649 0.139283278978806 no 542 0.147223273999991 797 17122249 SGTC_2312 7706453 155.7 µM 1.04651456958183 0.139714983152673 no 543 0.147661760891601 729 976098 SGTC_1231 0242-0792 125 µM 1.04433990782241 0.140209589217691 no 544 0.148164077617042 750 3707635 SGTC_972 1319-0219 195 µM 1.04375998564509 0.140341687610061 no 545 0.148298224486427 744 23903702 SGTC_977 1348-1378 135 µM 1.04364658839605 0.140367527838255 no 546 0.148324464889456 779 X977 SGTC_1932 st074806 40.9 µM 1.04318038162833 0.140473797950976 no 547 0.148432378916101 800 17251235 SGTC_2685 mycophenolic acid 18.85 µM 1.0413188341428 0.140898675235663 no 548 0.148863799203162 749 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1671 st016596 74.5 µM 1.0355844170521 0.14221296611543 no 549 0.150198032462885 806 2829167 SGTC_453 enantio-paf c16 10 µM 1.03506672297835 0.14233202517306 no 550 0.150318875975718 879 13871343 A lipid and platelet activating factor SGTC_2417 cerulenin 830 nM 1.03371770781212 0.142642587833916 no 551 0.150634076160172 750 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_55 0767-0285 6.563 µM 1.03144253987122 0.143167401487179 no 552 0.151166670355109 804 3116166 SGTC_1254 0550-0035 264 µM 1.03124110448298 0.143213929417837 no 553 0.151213884671778 818 15121435 SGTC_1703 st026983 48.3 µM 1.02938892676524 0.143642227648471 no 554 0.151648475224792 819 1104023 SGTC_746 1095-0025 46.6 µM 1.02897315495953 0.143738489549204 no 555 0.151746144909916 816 6749286 SGTC_1190 1486-1332 13 µM 1.02883584321137 0.143770290321344 no 556 0.151778410234377 776 4150046 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.02489174280546 0.144685752560876 no 557 0.152707135580707 798 3256 An antibiotic and ribosome inhibitor. SGTC_414 piperonyl butoxide 100 µM 1.02444125866197 0.144790563388813 no 558 0.152813451350616 755 5794 A potent inhibitor of cytochrome P450. SGTC_2084 5306078 60.6385 µM 1.02138674457092 0.14550258320428 no 559 0.153535621491086 752 679340 SGTC_2153 5569715 200 µM 1.02135517404671 0.145509954697192 no 560 0.153543097402617 767 2054701 SGTC_1547 harmine 94.2 µM 1.02037343400337 0.145739309356588 no 561 0.153775694103544 854 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_92 0063-0024 660.874 µM 1.0188470230327 0.146096392754106 no 562 0.154137798822742 868 3594437 SGTC_345 1362-0200 395 µM 1.01849089128635 0.146179789492554 no 563 0.154222363696896 738 1419823 SGTC_992 3909-8734 162 µM 1.01580213357613 0.146810458089915 no 564 0.154861809911122 762 4288319 SGTC_934 2950-0684 338 µM 1.01571619150186 0.146830646516948 no 565 0.154882277684993 834 1121253 SGTC_1161 k007-0610 110 µM 1.01528454470567 0.146932071697826 no 566 0.154985104752468 869 5843850 SGTC_3057 9095946 49.47 µM 1.01254102789653 0.147577821342441 no 567 0.15563972008847 812 24540043 SGTC_622 1348-1566 26.3 µM 1.01072131425899 0.148007179816136 no 568 0.156074916340115 836 7340407 SGTC_518 1021-0119 62.6 µM 1.0052153152295 0.149311399173244 no 569 0.157396591054804 748 1097762 SGTC_1191 1487-1166 10.6 µM 1.00258212472321 0.149937833559351 no 570 0.158031261994431 883 3955771 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.00192177053441 0.150095205889998 no 571 0.158190688545992 763 689007 SGTC_858 0438-0351 2.77 µM 1.00186544273291 0.15010863474702 no 572 0.158204292415711 840 2799119 SGTC_522 1273-0010 11.6 µM 1.00184095865054 0.150114472136365 no 573 0.158210205867715 777 5705015 SGTC_207 4185-0010 4.486 µM 1.00115673327761 0.150277663404607 no 574 0.158375520224434 891 3761753 SGTC_784 4579-0127 173 µM 1.00011710394969 0.150525846556034 no 575 0.15862691986302 864 1948547 SGTC_2608 thymoquinone 42.66 µM 0.999813424514924 0.150598393233046 no 576 0.158700403948309 749 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_501 nsc-95397 161 µM 0.997785134029866 0.151083533299174 no 577 0.159191780164054 789 262093 SGTC_2495 cafestol 54.53 µM 0.996873748691729 0.151301862771793 no 578 0.159412897667676 740 16667697 An anti-infammatory. SGTC_3003 9075612 71.4286 µM 0.994471688158332 0.151878300054535 no 579 0.159996641116986 776 6501993 SGTC_794 k038-0031 316 µM 0.99120518207177 0.152664521883632 no 580 0.160792700352012 880 6624242 SGTC_1746 st038117 42 µM 0.988922706051981 0.153215495156776 no 581 0.161350480152733 782 2898218 SGTC_2328 6201408 200 µM 0.988460281522727 0.15332728143259 no 582 0.161463638641929 774 2890418 SGTC_1633 st005664 67.9 µM 0.986270128200306 0.153857461859663 no 583 0.162000287115463 817 2063822 SGTC_1019 4262-0212 3.4 µM 0.985623322180848 0.154014268949557 no 584 0.162158994542876 886 4677213 SGTC_2323 6148992 148.28 µM 0.984932754144234 0.154181802066139 no 585 0.162328551611865 730 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2466 5983409 37.09 µM 0.984801685165399 0.154213613254099 no 586 0.162360746364809 784 2879657 SGTC_412 gemfibrozil 100 µM 0.983909239145613 0.154430330386622 no 587 0.162580070270293 772 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2292 7671323 168.05 µM 0.982508115496874 0.154770978252449 no 588 0.162924793413848 812 937504 SGTC_1164 k060-0068 93.7 µM 0.981912222021772 0.154916005066379 no 589 0.16307154701188 863 5963676 SGTC_976 1348-1067 47.6 µM 0.981771310778984 0.154950312750938 no 590 0.163106262469351 878 5310671 YGL099W LSG1 SGTC_407 eburnamonine 100 µM 0.981349682688087 0.155052996582284 no 591 0.163210165138401 754 3195 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.980465036381028 0.155268590455945 no 592 0.163428310089178 737 6857784 SGTC_1797 st048695 56.8 µM 0.980143170906751 0.155347080164712 no 593 0.163507725868086 828 592262 YIL048W NEO1 SGTC_2405 ticlatone 3.52 µM 0.978566312137705 0.155731989264641 no 594 0.163897155674285 812 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1439 4092-1168 46 µM 0.976209181911072 0.15630853329526 no 595 0.164480407012231 839 2886240 SGTC_2298 7976326 193.81 µM 0.97435217988088 0.156763736981328 no 596 0.164940852241517 759 2235818 SGTC_1694 st024011 44.9 µM 0.974242967047698 0.156790535269428 no 597 0.164967957619624 875 2787533 SGTC_2959 9079155 11 µM 0.973919013494443 0.156870043666582 no 598 0.165048376158298 766 16189457 SGTC_1207 2099-0101 141 µM 0.972331504135342 0.157260051892316 no 599 0.165442827859667 887 5837381 SGTC_459 nigericin 15.3 µM 0.970096360056285 0.15781024625347 no 600 0.16599923159527 868 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1484 3473-2379 286 µM 0.968498357001989 0.158204378558292 no 601 0.16639776958017 984 671917 SGTC_413 propylparaben 100 µM 0.968301455044663 0.158252987223492 no 602 0.166446919155389 812 7175 A pharmaceutical preservative. SGTC_1283 0922-0125 16.4 µM 0.96803195563013 0.158319533715774 no 603 0.16651420529727 893 3360884 SGTC_2119 5528445 120.635 µM 0.965493590276174 0.158947223609128 no 604 0.167148822451956 846 791935 SGTC_623 k072-0108 16.9 µM 0.964252169075551 0.159254796665652 no 605 0.167459757411567 822 5382803 SGTC_1106 tegaserod maleate 11.7 µM 0.963914516961662 0.159338520337352 no 606 0.167544392525339 862 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2790 5423970 71.43 µM 0.961858512082456 0.159848945920957 no 607 0.168060340653582 877 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_606 k015-0008 38.6 µM 0.961251185031778 0.159999925882511 no 608 0.168212942931587 921 1970475 SGTC_2521 angolensin 13.4 µM 0.96089198964837 0.160089264815179 no 609 0.168303239427282 806 821428 A flavenoid. SGTC_463 ikarugamyin 104 µM 0.955828111857378 0.161352220820752 no 610 0.169579541559816 835 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_547 1120-0019 610 nM 0.955245304267091 0.16149799175733 no 611 0.169726830076746 835 3676939 SGTC_3133 9127736 49.47 µM 0.954672523409624 0.161641338460369 no 612 0.169871664531362 842 27243420 SGTC_836 0330-0104 1.35 µM 0.95242905680727 0.162203596799501 no 613 0.17043971452511 848 46494820 SGTC_2250 alverine citrate 130 µM 0.951547761186104 0.162424815351132 no 614 0.170663192669167 894 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1857 st056007 79.3 µM 0.95091767827631 0.162583096026141 no 615 0.170823083461656 841 619834 SGTC_1723 st034307 2.5525 µM 0.950022842569244 0.162808056623359 no 616 0.17105032300986 847 867466 SGTC_371 0195-0006 7.36 µM 0.949686212830257 0.16289273730055 no 617 0.17113585866288 751 3928593 SGTC_532 1548-0774 215 µM 0.948576059994803 0.163172203999243 no 618 0.171418135838102 902 5932993 SGTC_1641 st009299 47.1 µM 0.945979355069727 0.163827107082813 no 619 0.172079558123399 811 4046054 SGTC_505 gw-5074 63.9 µM 0.944631492586083 0.164167716943325 no 620 0.172423521627064 858 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1251 0490-5699 265 µM 0.939611401397947 0.165440350326191 no 621 0.17370846292765 943 3883818 SGTC_1071 trifluoperazine 6.31 µM 0.938105242687379 0.165823414992953 no 622 0.1740951639218 888 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_3265 9137266 49.47 µM 0.934741109055655 0.166681091258898 no 623 0.174960867854446 857 17224265 SGTC_2033 5192550 145 µM 0.934184755678591 0.166823207335227 no 624 0.175104298934548 833 182073 SGTC_1471 k673-0312 37 µM 0.933670437743288 0.166954655303957 no 625 0.175236959365527 889 24099884 SGTC_2330 7979373 200 µM 0.933249812921315 0.167062207085517 no 626 0.175345500458701 846 1863007 SGTC_959 1222-0044 107 µM 0.932569577843156 0.16723623450862 no 627 0.175521123459387 885 6083612 SGTC_2931 9014674 55.67 µM 0.931353579274173 0.167547619617022 no 628 0.17583534747355 854 2996810 SGTC_123 0083-0120 66.675 µM 0.931098140311016 0.167613078226044 no 629 0.175901400255888 844 16001701 SGTC_2747 doxorubicin 7.63 µM 0.930392548094384 0.167793978371396 no 630 0.17608393773007 694 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1759 st043059 70 µM 0.929785686973038 0.167949666297411 no 631 0.176241029247829 877 669426 SGTC_2183 6420625 130.508 µM 0.924673905752813 0.169264762987547 no 632 0.177567778375634 925 2897619 SGTC_196 k015-0023 18.111 µM 0.923372822501476 0.169600542403687 no 633 0.177906474844592 909 5211998 SGTC_1596 piperlongumine 63 µM 0.923167379746319 0.169653601452692 no 634 0.177959992684693 934 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2715 st079500 56.4 µM 0.92183333314911 0.169998400455103 no 635 0.178307758795429 836 28246688 SGTC_766 1391-0721 126 µM 0.92134278705386 0.170125300359244 no 636 0.178435744482724 901 1020919 YIL115C NUP159 SGTC_859 0439-0102 54.6 µM 0.9194974611739 0.170603213253649 no 637 0.178917716478473 956 610143 SGTC_2155 5570423 76 µM 0.917590558564014 0.171097975744663 no 638 0.17941663132282 830 797402 SGTC_365 0121-0052 13.6 µM 0.9165702909089 0.171363069545553 no 639 0.179683929147773 931 3101739 SGTC_405 ebelactone b 50 µM 0.915533018025809 0.17163285077466 no 640 0.179955938503847 882 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1445 4239-0156 97.7 µM 0.915334066544198 0.171684626472605 no 641 0.18000814010487 976 4008346 SGTC_3096 9117468 49.47 µM 0.914366190950587 0.171936651482274 no 642 0.180262230386008 787 41316311 SGTC_1037 k284-1091 78.7 µM 0.913978143861123 0.172037761320294 no 643 0.180364165124193 831 3334711 SGTC_1341 1486-1360 280 µM 0.913530423577489 0.172154466799557 no 644 0.180481820133279 890 3976547 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.91184629993968 0.17259391300841 no 645 0.180924816706866 864 17037758 SGTC_812 4251-0442 148 µM 0.910566216939064 0.17292840901973 no 646 0.181261988722253 898 5723007 SGTC_870 0573-2213 57.6 µM 0.910273231062431 0.173005026644916 no 647 0.181339216085042 878 3916321 SGTC_2477 5967686 25.23 µM 0.908520549436657 0.173463815321138 no 648 0.181801630894535 873 776118 SGTC_361 000s-0510 1.45 µM 0.908519664085708 0.173464047269515 no 649 0.181801864665345 873 660 SGTC_2342 7990637 118.86 µM 0.908290542112764 0.173524080350262 no 650 0.18186236906267 903 2033102 YER133W GLC7 SGTC_3332 9141069 11.198 µM 0.906982034363592 0.173867180557438 no 651 0.182208148906314 840 17332883 SGTC_3113 9123498 49.47 µM 0.906431221682864 0.17401173657158 no 652 0.182353826774077 939 8897275 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.902136880723019 0.175141368037687 no 653 0.183492079743735 987 91467 include heat shock SGTC_2498 4'-Methoxychalcone 54.63 µM 0.900735665146736 0.175510963682739 no 654 0.183864440508483 915 641818 YHR062C RPP1 SGTC_370 0180-0345 38.7 µM 0.899587283666847 0.175814238126154 no 655 0.184169963470417 836 3989527 SGTC_3345 9148410 3.559 µM 0.898383100704037 0.176132605399864 no 656 0.184490671403804 912 4903596 SGTC_1371 2421-0008 32.7 µM 0.897197388354515 0.176446445666013 no 657 0.18480679928076 873 2827552 SGTC_1454 4239-0054 42.6 µM 0.896867168323318 0.176533912892859 no 658 0.184894900573395 973 1340767 SGTC_2268 7933382 153.85 µM 0.89643910659301 0.176647336805087 no 659 0.185009144452723 1023 935025 YOR257W CDC31 SGTC_3346 9158254 43.5805 µM 0.895342146245928 0.176938209695607 no 660 0.185302108460927 893 17639500 SGTC_1647 st011722 22.4 µM 0.894861623603673 0.177065721621264 no 661 0.185430531797309 876 2854783 SGTC_2475 5812728 15.03 µM 0.894573554679326 0.177142191680088 no 662 0.185507546893425 1001 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1355 1499-0035 1.68 µM 0.890430397493538 0.178244330691789 no 663 0.186617413168423 889 1548538 SGTC_1240 0356-0016 42.1 µM 0.890240478387461 0.178294955263117 no 664 0.186668386933722 892 4305613 SGTC_1711 st032263 62.8 µM 0.888825750685529 0.178672348181492 no 665 0.187048367163027 899 3958979 SGTC_1466 k213-0079 57.5 µM 0.888456049093741 0.178771052654801 no 666 0.187147743727172 938 3657981 SGTC_3054 9094397 49.47 µM 0.886519699542579 0.179288587903851 no 667 0.187668771775002 974 2598354 SGTC_2687 chenodiol 100 µM 0.881632348929201 0.18059903294598 no 668 0.188987827869543 882 5702181 A cholesterol synthesis inhibitor. SGTC_3083 9117465 49.47 µM 0.881174458022437 0.18072211420487 no 669 0.189111700819834 974 16420915 SGTC_1719 st032227 49.2 µM 0.880291248404981 0.180959669815605 no 670 0.189350776186742 934 3125804 SGTC_1213 1315-0166 115 µM 0.878957415209851 0.181318799711613 no 671 0.18971218296914 809 768401 SGTC_2311 7694451 200 µM 0.87431287563095 0.182572805007066 no 672 0.190973944664174 904 2163142 SGTC_3263 9137018 49.47 µM 0.872279729029921 0.183123446010456 no 673 0.191527896714808 912 43844957 SGTC_3197 9113331 49.47 µM 0.870283368509347 0.18366513104925 no 674 0.192072782781177 935 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_84 0443-0269 128.823 µM 0.869880986481274 0.18377443266664 no 675 0.192182723568446 956 6150058 SGTC_2217 6934799 96.0675 µM 0.869831876753601 0.183787775431645 no 676 0.192196144204088 959 675606 SGTC_348 k064-0012 10.7 µM 0.866951816149211 0.184571322654129 no 677 0.192984205440813 882 5066323 SGTC_10 0279-0212 42.575 µM 0.866751562839167 0.184625880560882 no 678 0.193039073350574 1034 39851 YBR002C RER2 SGTC_2436 5633522 8.09 µM 0.866364446992914 0.184731376558272 no 679 0.193145167199524 983 5724242 SGTC_1396 3511-0007 98.6 µM 0.864711771152329 0.185182181681173 no 680 0.19359850353119 858 X1396 SGTC_1094 duloxetine 25.4 µM 0.863688622247847 0.185461611068638 no 681 0.193879482768437 943 60834 A selective serotonin reuptake inhibitor. SGTC_2171 5739187 198.077 µM 0.863201464365268 0.185594749343522 no 682 0.194013354358531 929 2262761 SGTC_550 4123-0385 25.7 µM 0.86288498711949 0.185681273063244 no 683 0.194100352869804 938 5731123 SGTC_775 4577-0580 57.3 µM 0.862737712719972 0.18572154587584 no 684 0.19414084619959 956 2006902 SGTC_1812 st052057 4.327 µM 0.861810441372913 0.185975236627154 no 685 0.194395919103923 1006 3645418 SGTC_1882 5615643 20 µM 0.859507252751187 0.186606291521588 no 686 0.195030360159013 935 2253075 SGTC_822 1487-0950 154 µM 0.85694570253448 0.187309690649592 no 687 0.195737446625459 969 1958375 SGTC_1047 2043-3044 82 µM 0.855451071284827 0.187720871157722 no 688 0.196150740294251 1010 669592 SGTC_515 4092-1064 102 µM 0.855346235767246 0.187749732841412 no 689 0.196179749135702 1035 717353 SGTC_1954 st077032 68.9 µM 0.853658965047351 0.188214622933681 no 690 0.19664698847562 886 698907 SGTC_1088 bifonazole 369 nM 0.853254950260369 0.188326045577951 no 691 0.196758968281948 936 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2166 5933061 31.504 µM 0.852608093126943 0.188504526066068 no 692 0.196938336509132 1031 2877375 SGTC_148 3253-0744 288.01 µM 0.850446297720328 0.189101763978851 no 693 0.197538502634902 985 6893655 SGTC_1299 1079-1439 3.74 µM 0.850206421798723 0.189168106108918 no 694 0.197605166016685 952 323161 SGTC_2954 9074818 52.69 µM 0.849772360798118 0.18928819014588 no 695 0.197725829502308 937 16648742 SGTC_1961 st076550 68.7 µM 0.845990851399177 0.190336338193926 no 696 0.198778923959587 911 1579337 SGTC_1718 roemerine 11.9335 µM 0.845539134785628 0.190461781642035 no 697 0.198904946057853 954 235224 An aporphine alkaloid with mutagenic activity. SGTC_2601 securinine 100 µM 0.844029136191516 0.190881482449299 no 698 0.199326562215281 932 442872 A GABA receptor antagonist. SGTC_1028 k015-0029 4.8 µM 0.843812424599661 0.190941763486974 no 699 0.199387115742675 1026 4588309 SGTC_528 3492-0019 172 µM 0.842180344544847 0.191396121990906 no 700 0.199843507049254 1076 2869262 SGTC_1782 st039423 80.636 µM 0.841318480089447 0.191636325504458 no 701 0.200084770244777 914 2068169 SGTC_330 1488-0319 80.1 µM 0.84114289850245 0.191685283107268 no 702 0.200133942559103 959 6846614 SGTC_265 mycophenolic acid 32.932 µM 0.839781627355606 0.192065107647996 no 703 0.20051541829445 1023 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2796 7949634 45.45 µM 0.839466032273906 0.192153231323808 no 704 0.200603921377016 916 2971588 SGTC_658 3253-0951 102 µM 0.839217695657852 0.192222591793035 no 705 0.200673579493953 1039 1184878 SGTC_2186 6124449 200 µM 0.837406441202482 0.19272893860669 no 706 0.201182073189661 980 3834182 YLR033W RSC58 SGTC_1425 4048-4433 7.33 µM 0.837071625697639 0.192822627418166 no 707 0.201276154227368 1052 23734946 SGTC_1937 st074714 47.2 µM 0.83280647434135 0.194018544763903 no 708 0.202476941373553 1013 17250970 SGTC_2681 menadione 3.18 µM 0.830796827450868 0.194583598040843 no 709 0.203044207601284 996 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_512 prima-1 270 µM 0.830556734287279 0.194651172042194 no 710 0.20311204248275 1034 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1429 4049-0205 9.46 µM 0.830502245696604 0.1946665097939 no 711 0.203127439336464 1031 22774478 SGTC_3202 9113761 49.47 µM 0.83044288810414 0.19468321893611 no 712 0.203144212818085 1041 4798415 SGTC_2750 bromebric acid 70.15 µM 0.826085719223416 0.195912142300128 no 713 0.204377734022432 1036 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_61 0978-8327 98.565 µM 0.823828446614603 0.196550644375037 no 714 0.205018520861891 1076 6150059 YHR072W ERG7 SGTC_1348 1493-0373 93.8 µM 0.82326024678619 0.196711566297732 no 715 0.205180007432392 997 3010129 SGTC_489 paxilline 115 µM 0.823112789700467 0.196753341188946 no 716 0.20522192816993 992 105008 A toxic potassium channel blocker. SGTC_531 3788-1495 174 µM 0.823002804308231 0.196784503771471 no 717 0.20525319935151 943 2896655 SGTC_1198 1612-1005 86.7 µM 0.822917268975259 0.196808740891031 no 718 0.205277520819032 1037 6998509 SGTC_1170 0310-0127 64.8 µM 0.822529662815496 0.196918594845234 no 719 0.205387755800888 1012 774975 SGTC_2204 7233102 200 µM 0.820915359478307 0.197376514045199 no 720 0.205847240784444 957 2172480 SGTC_2137 5261020 140 µM 0.820542615644505 0.197482339373878 no 721 0.205953422809666 985 763655 SGTC_2428 5615643 7.78 µM 0.819982767994006 0.197641349604911 no 722 0.206112965368753 984 2253075 SGTC_1828 st055811 49 µM 0.818131576737696 0.19816768329875 no 723 0.206641030022859 983 5877589 SGTC_1204 4049-0315 18.3 µM 0.817605975418632 0.198317277215076 no 724 0.206791107214452 965 588402 SGTC_616 4092-0450 108 µM 0.81728057812188 0.198409924250595 no 725 0.206884051626752 1035 787165 SGTC_673 1082-0474 110 µM 0.81651456333166 0.198628126864584 no 726 0.207102948805486 1107 3098046 SGTC_2375 9072683 200 µM 0.815492277910131 0.198919554617061 no 727 0.207395291483845 1097 16798029 SGTC_2868 9035608 32.47 µM 0.814512887350277 0.199198995700158 no 728 0.207675596218397 1054 6462614 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.813406752931203 0.199514883679596 no 729 0.207992444440985 1050 115019 SGTC_2872 9044037 25.97 µM 0.812499473292874 0.199774207989249 no 730 0.208252544340723 1034 6465195 SGTC_910 3454-3003 490 µM 0.812358186272986 0.199814609762204 no 731 0.208293065917338 1016 820824 SGTC_1635 st007035 42.4 µM 0.811540688833702 0.200048473962602 no 732 0.208527618145187 1078 3716403 SGTC_1930 st074634 34.3 µM 0.81033119587008 0.200394779289658 no 733 0.208874925246613 1055 684253 YOR116C RPO31 SGTC_2120 5538279 151.968 µM 0.80762896839511 0.2011697883672 no 734 0.209652102677145 1005 2058197 SGTC_2467 5474540 200 µM 0.807427200881451 0.201227728076143 no 735 0.209710200417721 1035 5413519 SGTC_1888 azatryptophan 97.5 µM 0.806290513811324 0.201554326895098 no 736 0.210037679463893 932 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_16 erodoxin 22.806 µM 0.803650991692653 0.202313952041826 no 737 0.210799282577956 1074 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1374 2889-5571 141 µM 0.803612359833726 0.202325082560655 no 738 0.210810441360149 1032 2853281 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.801052220453993 0.203063519879853 no 739 0.211550707521327 963 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1625 st003711 30.1 µM 0.79392818228493 0.205126803489126 no 740 0.213618620983494 1060 24207034 YER133W GLC7 SGTC_1540 guanosine 70.6 µM 0.79356690748365 0.205231767756059 no 741 0.21372380199378 1005 6802 Guanosine is a purine nucleoside SGTC_3213 9129884 49.47 µM 0.792290592223419 0.205602841998732 no 742 0.214095627971487 1010 17190742 SGTC_1505 k297-0037 20.6 µM 0.791992652921008 0.205689521789013 no 743 0.214182480106304 1029 4089396 SGTC_2581 avocatin a 64 µM 0.790881828294854 0.206012886271167 no 744 0.214506476673158 1033 6710728 A skin care supplement. SGTC_94 0334-0113 514.748 µM 0.790185411360422 0.206215769062794 no 745 0.21470974731088 1036 6795178 SGTC_2809 7964133 12.99 µM 0.790027191800451 0.206261878683496 no 746 0.214755944140417 1028 1253665 SGTC_3266 9136860 49.47 µM 0.789551920319569 0.206400422877253 no 747 0.214894748279941 1021 4871271 YPR165W RHO1 SGTC_1469 k284-2957 126 µM 0.789228439928581 0.206494750680628 no 748 0.214989251275575 1077 23884841 SGTC_592 k241-0073 46.5 µM 0.788902538904335 0.206589810168309 no 749 0.215084485846943 1084 4230158 SGTC_1407 3909-7909 12.3 µM 0.786787685844761 0.207207304439786 no 750 0.215703081633673 1074 4411780 SGTC_456 gingerol 170 µM 0.78666677518141 0.207242640862779 no 751 0.215738479217079 1134 442793 A herb. SGTC_1265 0819-1001 68.8 µM 0.784002365461001 0.208022224965106 no 752 0.216519361161224 1061 3106768 SGTC_1795 st049545 62.3 µM 0.783759350570816 0.208093415143354 no 753 0.216590664958519 1057 5291882 SGTC_1105 epirubicin 18.1 µM 0.782864051291615 0.208355813303231 no 754 0.216853474842461 1052 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_932 2857-0803 154 µM 0.781476922886558 0.208762744073716 no 755 0.217261022180871 1109 674898 SGTC_1552 6-methylflavone 10.6 µM 0.779094132569802 0.209462856459885 no 756 0.217962133099602 1043 689013 SGTC_2382 9035899 200 µM 0.778297540787588 0.209697219115461 no 757 0.21819681247158 1091 6462679 SGTC_2344 7990960 76.95 µM 0.7780900532595 0.209758288642784 no 758 0.218257963085734 1011 140813 SGTC_2927 9011802 47.9 µM 0.776948952217451 0.210094334227992 no 759 0.21859444421175 1039 43912568 SGTC_1910 st062352 60.4 µM 0.776811809218124 0.21013474307821 no 760 0.21863490422162 1086 2245730 SGTC_1877 wortmannin 25 µM 0.775582572219499 0.210497138565074 no 761 0.218997746894362 1098 312145 A covalent inhibitor of PI 3-kinase. SGTC_1574 spiramycin 23.7 µM 0.774091077010766 0.210937343459691 no 762 0.219438466901311 1106 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3306 9127676 59.7925 µM 0.768367862732178 0.212631513896164 no 763 0.221134333792893 1080 41905287 SGTC_383 2324-0395 7.37 µM 0.765822112091927 0.21338764627636 no 764 0.221891077648449 1097 3146421 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.765506881125238 0.213481384314659 no 765 0.221984885260263 1090 2333 A French combination drug. SGTC_940 3232-1287 54.8 µM 0.765329033961163 0.213534280075334 no 766 0.222037819675242 1085 1585493 YIL048W NEO1 SGTC_679 0422-0091 41.4 µM 0.765067151133536 0.213612183840836 no 767 0.222115779574789 1144 627384 YHR062C RPP1 SGTC_245 methotrexate 289.6 µM 0.764215111384494 0.213865759474734 no 768 0.222369531369726 1088 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3021 9087658 49.47 µM 0.764178861538573 0.213876551680661 no 769 0.22238033085076 1087 25237042 SGTC_379 3970-0972 5.9 µM 0.762619322051039 0.214341153752268 no 770 0.222845228928637 1063 2898042 YBL034C STU1 SGTC_2092 5303694 80.6725 µM 0.761931438928364 0.214546267279041 no 771 0.223050462463326 1074 1963699 SGTC_2641 levomentholum 100 µM 0.761301611324492 0.214734169793677 no 772 0.223238469187951 1070 16666 SGTC_2374 9071832 200 µM 0.761237059076469 0.214753433686654 no 773 0.223257743455316 1069 17381698 SGTC_1840 st055363 71 µM 0.760170898954088 0.215071745899371 no 774 0.223576218773173 1046 676033 SGTC_255 tunicamycin 200.472 nM 0.760020792501697 0.215116583592384 no 775 0.223621078181696 1088 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2414 st077232 92.9 µM 0.759754903288755 0.215196019605252 no 776 0.22370055190354 1023 729801 SGTC_2985 9022375 71.43 µM 0.759442650741436 0.215289328679675 no 777 0.223793904027369 1152 4939335 SGTC_2021 4019055 173 µM 0.758605135524059 0.215539715627585 no 778 0.224044399852131 1130 44827708 YER133W GLC7 SGTC_1331 1472-0049 76.2 µM 0.756189233628722 0.216262928990104 no 779 0.22476787346037 1090 24051409 SGTC_2611 pyromycin 23.93 µM 0.753180552198517 0.217165555439687 no 780 0.225670712114048 1104 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3340 9146634 11.102 µM 0.751979359405889 0.217526529089112 no 781 0.226031735768772 1109 4907387 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.749674500664819 0.218220137290462 no 782 0.226725384374621 1097 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1040 k898-0338 155 µM 0.749113552216349 0.218389137848286 no 783 0.226894383707374 1161 20969351 SGTC_941 3237-0776 460 µM 0.747630481038325 0.21883631522962 no 784 0.227341536979185 1117 760008 SGTC_296 1222-0039 74.9 µM 0.747473781132724 0.218883594324808 no 785 0.2273888117572 1090 5984176 SGTC_2095 5432005 200 µM 0.743423568729886 0.220107651359277 no 786 0.228612639724375 1120 783734 SGTC_3253 9135987 49.47 µM 0.742825347089485 0.220288778385681 no 787 0.22879371372692 1076 4182430 SGTC_5 0352-0601 109.883 µM 0.742563550463108 0.220368070938841 no 788 0.228872981520366 1066 762456 SGTC_1661 st013063 9.66 µM 0.74060037694753 0.220963194973868 no 789 0.229467889699888 1166 721395 SGTC_2692 st077426 47.7 µM 0.73942452871953 0.221320086239305 no 790 0.229824626154886 1143 25238571 SGTC_1123 mangostin 811.285 nM 0.739328982104565 0.221349100845063 no 791 0.229853627340623 1057 5281650 An antioxidant. SGTC_1301 naphtanilide LB 4.81 µM 0.736790250968588 0.222120832747053 no 792 0.230624956361518 1182 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_833 3852-0053 558 µM 0.736367340426077 0.22224953955426 no 793 0.23075358737891 1165 3123681 SGTC_42 0133-0086 60.653 µM 0.735047445706079 0.222651504276583 no 794 0.231155299616023 1120 162923 Model of phenazepam hydroxylation. SGTC_88 0180-0332 8.668 µM 0.732650614348833 0.223382501051312 no 795 0.231885776095696 1186 3101745 SGTC_2070 5230947 200 µM 0.732108866958148 0.223547914701545 no 796 0.232051061093416 1221 2835538 SGTC_3104 9120930 49.47 µM 0.732084157303487 0.223555461048857 no 797 0.232058601475534 1108 17014836 SGTC_938 3126-1755 342 µM 0.731845565054656 0.223628334756392 no 798 0.232131417147755 1168 1777771 SGTC_2972 9093619 59.92 µM 0.729214139588617 0.224432951831784 no 799 0.232935341664659 1141 25236256 SGTC_2176 5809774 33.9695 µM 0.729131927811756 0.224458116356904 no 800 0.232960483001378 1149 2870539 SGTC_1546 5-methoxyflavanone 78.7 µM 0.727844336812604 0.224852448999222 no 801 0.23335444019742 1173 147795 SGTC_2082 5219693 150 µM 0.724918109257875 0.225750083131309 no 802 0.234251135219109 1178 2834649 SGTC_2239 6685329 187.64 µM 0.723928854078602 0.226053999682864 no 803 0.234554707297483 1125 805680 SGTC_24 0417-1663 219 µM 0.722206592158929 0.226583660161043 no 804 0.235083735486154 1141 4329390 SGTC_742 0kpi-0133 140 µM 0.721145186959462 0.226910430877182 no 805 0.235410095911084 1160 2728852 SGTC_1014 4130-3005 69.3 µM 0.720362677670957 0.227151509104101 no 806 0.235650861579849 1192 743608 SGTC_2870 9038528 12.99 µM 0.718306203058917 0.227785762873249 no 807 0.236284253137619 1148 6463316 SGTC_1524 corynanthine 62.1 µM 0.71614099646258 0.228454627324862 no 808 0.236952145874665 1160 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_3247 9135149 49.47 µM 0.715811192516265 0.228556605411987 no 809 0.237053970192739 1129 8934436 YOR116C RPO31 SGTC_807 1315-0151 48 µM 0.715686201404945 0.22859526036987 no 810 0.237092566476385 1201 4011080 SGTC_872 0588-0139 234 µM 0.714791585800124 0.228872037837434 no 811 0.237368917600845 1191 2047100 SGTC_2766 oltipraz 83.91 µM 0.714676160121761 0.228907762094339 no 812 0.23740458603347 1131 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_757 1066-0008 322 µM 0.713350541221421 0.229318265522839 no 813 0.237814434961016 1149 6842497 SGTC_2855 9016525 58.44 µM 0.713153655910737 0.229379270032364 no 814 0.237875340161682 1209 43811474 SGTC_3095 9117207 49.47 µM 0.713051875813189 0.22941080995315 no 815 0.237906828531604 1125 17015229 SGTC_1523 st012844 44.7 µM 0.712981804575903 0.229432525250234 no 816 0.237928508253733 1163 4274103 SGTC_2026 5148700 152 µM 0.711540737963813 0.229879371714126 no 817 0.238374607827253 1171 79838 SGTC_574 1315-0397 40 µM 0.709977914672565 0.230364522731988 no 818 0.23885891592659 1225 6794277 SGTC_221 trifluoperazine 10.304 µM 0.709205400725948 0.230604547376484 no 819 0.239098511252124 1209 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1285 0929-0069 65.5 µM 0.707006865423877 0.231288409479793 no 820 0.239781105673869 1162 1206237 SGTC_2917 7979103 53.79 µM 0.702443854028619 0.232711353991197 no 821 0.241201202295988 1194 2980565 SGTC_604 1000-0114 314 µM 0.702354288813907 0.232739332905626 no 822 0.241229122379104 1215 1572745 SGTC_2665 lovastatin 100 µM 0.701699400605333 0.232943967576751 no 823 0.241433323451931 1184 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_321 4534-3890 65.3 µM 0.700410178323449 0.233347106178677 no 824 0.24183559081747 1210 699746 SGTC_2184 6075246 200 µM 0.698685931821377 0.233886881021923 no 825 0.242374163837586 1195 2267320 SGTC_2879 9041815 71.43 µM 0.697944037048571 0.234119343663019 no 826 0.24260609647274 1141 4942971 SGTC_421 streptovitacin 30 mM 0.696882566899933 0.234452163272865 no 827 0.242938144276134 1204 91467 include heat shock SGTC_936 3005-4620 401 µM 0.695328304016855 0.234939967950639 no 828 0.243424790153961 1206 777207 SGTC_1426 4048-4480 71.7 µM 0.693865450281258 0.235399595772603 no 829 0.243883296177972 1194 14224343 SGTC_215 1287-0124 461.5 µM 0.693302294924277 0.235576671083823 no 830 0.244059931574381 1198 5560863 SGTC_1180 1193-0155 285 µM 0.692604098583141 0.235796309889858 no 831 0.244279018756841 1196 2921347 SGTC_2151 5563267 85.4165 µM 0.691117414720802 0.236264367264438 no 832 0.244745878598811 1200 5310824 SGTC_235 0330-0087 5 mM 0.689462207296842 0.236786082798611 no 833 0.24526622409521 1233 46494818 YHR062C RPP1 SGTC_3110 9122132 49.47 µM 0.685622546284855 0.237998766163003 no 834 0.246475580072236 1282 918317 SGTC_1155 4088-0394 48.2 µM 0.68556777088149 0.238016090520203 no 835 0.246492855452045 1191 2326248 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.685554941929716 0.238020148159249 no 836 0.246496901613951 1215 5357218 A potent inhibitor of glutathione S-transferases. SGTC_971 1315-0384 26.7 µM 0.685552098828554 0.238021047402175 no 837 0.246497798313043 1216 6769120 SGTC_1134 3477-0009 42.5 µM 0.684854978551875 0.238241595396146 no 838 0.246717719110637 1251 3973534 SGTC_1323 1348-1351 11.2 µM 0.683833308088768 0.238565023521725 no 839 0.24704021560502 1156 6989654 SGTC_1002 4049-0206 172 µM 0.683726699806027 0.23859878612918 no 840 0.247073880147368 1246 4662749 SGTC_3043 9092303 49.47 µM 0.682675319889696 0.238931895855228 no 841 0.247406014119712 1175 25236084 SGTC_1645 Cervolide 78 µM 0.680747412024186 0.239543376933393 no 842 0.248015665250666 1170 23173 A fragrance. SGTC_551 k048-0028 34.9 µM 0.678881258785902 0.240136083896576 no 843 0.248606550670028 1223 6836383 SGTC_3311 9131146 2.8755 µM 0.67774526002448 0.240497278315431 no 844 0.248966612046747 1212 4900406 YPR165W RHO1 SGTC_1470 k295-0292 231 µM 0.67744137759615 0.24059394883081 no 845 0.249062976364909 1254 5045612 SGTC_513 4245-1575 41.7 µM 0.676899907288119 0.240766252780034 no 846 0.249234731469689 1212 719745 SGTC_1369 1866-0067 208 µM 0.676696860742785 0.240830882534183 no 847 0.249299154338747 1247 3531355 SGTC_1413 3910-0535 34.4 µM 0.675834946410948 0.241105335076686 no 848 0.249572722154551 1237 2876951 SGTC_3179 9107801 49.47 µM 0.674593754424198 0.241500856557353 no 849 0.249966951052106 1231 4818259 SGTC_1276 0871-0068 94.2 µM 0.674288057569192 0.2415983247699 no 850 0.250064097551078 1196 3414906 SGTC_1008 4106-0037 6 µM 0.673872222994295 0.24173094351117 no 851 0.250196276538549 1208 2905394 SGTC_3257 9139206 32.98 µM 0.672699654787766 0.242105113857704 no 852 0.250569193633067 1192 4910041 SGTC_1222 0366-0074 1.18 µM 0.670579786744379 0.242782367005305 no 853 0.251244131426538 1263 286520 SGTC_269 exalamide 29 µM 0.670476166499708 0.242815497753867 no 854 0.251277147360935 1215 3316 A derivative of salicylamide. SGTC_2202 7226349 200 µM 0.670383442055064 0.242845146836475 no 855 0.251306693572738 1191 844334 SGTC_843 0310-0051 143 µM 0.669900900734358 0.242999473341925 no 856 0.251460482760258 1244 2065037 SGTC_2774 tamoxifen 10.92 µM 0.669355994320352 0.243173809227061 no 857 0.251634207900002 1274 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_72 0744-0168 198.391 µM 0.668822711247853 0.24334449182498 no 858 0.251804288689295 1178 677577 SGTC_2060 5238662 140 µM 0.6669539396929 0.243943121526246 no 859 0.25240077753992 1215 790130 SGTC_183 3914-0051 30.55 µM 0.666204320786256 0.244183472492189 no 860 0.252640255775488 1232 1596232 SGTC_1092 toremifene 6.32 µM 0.664624017800977 0.244690584466754 no 861 0.253145501690382 1257 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_732 3970-1727 52.7 µM 0.663326037288122 0.245107524234756 no 862 0.253560882159333 1253 1275699 SGTC_1663 st014140 55.4 µM 0.661958790608616 0.245547126710899 no 863 0.253998816158573 1315 4207120 SGTC_1246 0422-0085 105 µM 0.661950889282562 0.245549668406316 no 864 0.254001348134413 1237 264295 SGTC_1602 st001878 87.6 µM 0.661775103766093 0.245606218675902 no 865 0.254057681936564 1272 595405 YLR310C CDC25 SGTC_1032 k061-1018 98.7 µM 0.661444465733147 0.245712604010135 no 866 0.254163658919832 1356 4005393 SGTC_3016 9080866 49.47 µM 0.66039100821126 0.246051727026546 no 867 0.254501470479662 1249 17066299 SGTC_717 1532-0246 73.2 µM 0.658439799995066 0.246680511440052 no 868 0.255127784012748 1240 9561992 SGTC_549 1661-1316 519 µM 0.657615184243844 0.246946505514603 no 869 0.255392717521009 1282 2857282 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.656309183125325 0.247368092611464 no 870 0.255812605070989 1267 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_410 α-linolenic acid 100 µM 0.656285850730912 0.247375627982212 no 871 0.255820109857096 1284 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1322 1348-1070 12 µM 0.655959504574089 0.247481036764911 no 872 0.255925090043241 1240 6758089 SGTC_1243 0416-0003 5.65 µM 0.655674004049629 0.247573272215761 no 873 0.256016949294073 1256 2141977 SGTC_2258 7960471 200 µM 0.654310346581159 0.2480140765017 no 874 0.25645594065405 1213 2974708 SGTC_660 4031-1742 102 µM 0.65353939248488 0.248263473727547 no 875 0.256704301178715 1190 6738706 SGTC_2638 epoxomicin 18 µM 0.651103844821876 0.249052230781731 no 876 0.257489727379112 1255 9915668 A protesome inhibitor. SGTC_2778 tioconazole 65.09 nM 0.650261655331842 0.249325285453661 no 877 0.257761610552819 1232 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2770 toltrazuril 17.5 µM 0.64977813773096 0.24948212341419 no 878 0.257917771352806 1246 68591 Kills coccidiodes. SGTC_2014 4013930 200 µM 0.647684847971928 0.250161725382867 no 879 0.258594403143353 1248 64556 SGTC_1556 plumbagin 1.48 µM 0.647573637328433 0.250197858187446 no 880 0.258630376398172 1210 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2522 biochanin a 4.94 µM 0.646457551431152 0.250560632395555 no 881 0.258991539606142 1238 5280373 A possible chelator. SGTC_2065 5221596 34.26 µM 0.646288581414333 0.250615578938143 no 882 0.259046240698516 1279 788581 SGTC_2300 7976697 71.57 µM 0.645881227246243 0.250748070708023 no 883 0.259178139056392 1208 2236109 SGTC_1846 st056244 14.8 µM 0.645196030893986 0.250971014166729 no 884 0.259400079003641 1292 5393182 SGTC_1687 st020778 55.3625 µM 0.645170072046821 0.250979462501161 no 885 0.259408489187743 1276 4259299 SGTC_2152 5568786 200 µM 0.644741083548946 0.251119099055082 no 886 0.2595474938843 1244 5399883 SGTC_1732 st034308 51.822 µM 0.644467425101161 0.251208196853494 no 887 0.259636187235702 1240 830119 SGTC_793 0488-0545 106 µM 0.644275272534623 0.251270767932061 no 888 0.259698473686701 1255 292548 SGTC_2420 aureobasidin a 50 nM 0.643399426878772 0.251556075903953 no 889 0.25998247761358 1386 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1159 4092-0538 61.2 µM 0.642455595527626 0.251863721805154 no 890 0.260288705958663 1306 717301 SGTC_3303 9125618 40.5795 µM 0.64212093309265 0.251972854146324 no 891 0.260397332603285 1315 22695467 SGTC_3269 9137823 49.47 µM 0.641918708078849 0.252038811164453 no 892 0.26046298326945 1217 17682936 SGTC_792 4534-1957 155 µM 0.641232961108948 0.25226253984856 no 893 0.260685668753531 1300 1717904 SGTC_1908 st060353 56.5 µM 0.639233794087735 0.252915376140843 no 894 0.261335425374195 1324 4227716 SGTC_3282 9108498 15.4605 µM 0.639210355263945 0.252923035456266 no 895 0.261343048243288 1260 16459645 SGTC_1070 indatraline 8.81 µM 0.638984824068016 0.252996740553309 no 896 0.261416402247347 1265 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3056 9094900 49.47 µM 0.638312335338373 0.253216581423942 no 897 0.261635191905649 1216 25236784 SGTC_3052 9092717 49.47 µM 0.6375618645693 0.253462033674172 no 898 0.261879463398621 1281 25237534 SGTC_804 1595-0054 20.9 µM 0.63749069185893 0.253485318221158 no 899 0.261902635546907 1288 761523 Stimulates phospholipase C. SGTC_3062 9077494 49.47 µM 0.634782081571121 0.25437228976508 no 900 0.262785275626804 1286 16459633 SGTC_1607 st000305 50.6 µM 0.634747870581879 0.254383503015722 no 901 0.262796433496984 1322 5457690 SGTC_2421 5690543 90.72 µM 0.634721418129716 0.254392173447612 no 902 0.262805061096372 1325 3397993 SGTC_1825 st052143 62.6 µM 0.63391674754448 0.254655997720669 no 903 0.263067577634917 1332 674173 SGTC_2045 5106652 78.05 µM 0.633319729146054 0.254851832419421 no 904 0.263262436076234 1270 673349 SGTC_3 0833-0587 95.581 µM 0.631275207423616 0.255523075638677 no 905 0.263930297353111 1224 5382644 SGTC_57 miconazole 162.5 nM 0.625585005541831 0.257396094339117 no 906 0.265793588166098 1234 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_677 0929-0063 136 µM 0.622086247799041 0.258551296731118 no 907 0.266942578614136 1286 1539583 SGTC_2359 9039622 200 µM 0.621835580830092 0.25863416365232 no 908 0.267024993742516 1272 6463596 SGTC_1435 4092-0789 56.7 µM 0.621577445962527 0.258719513723419 no 909 0.267109877618839 1359 2248285 SGTC_1160 4092-0570 10.5 µM 0.612767037883652 0.26164131544968 no 910 0.270015194411482 1308 4994975 SGTC_162 k030-0015 37.8 µM 0.610919024646605 0.262256314833984 no 911 0.270626594678013 1369 1809920 YMR134W ERG29 SGTC_1550 gossypolone 36.6 µM 0.610266597758881 0.262473612377912 no 912 0.270842609872181 1315 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2805 7950783 58.44 µM 0.610182007462534 0.262501792802249 no 913 0.270870623586196 1348 1178958 YDL195W SEC31 SGTC_2331 7980721 200 µM 0.609736973354781 0.262650077037295 no 914 0.271018029057454 1320 2981221 SGTC_773 4358-1457 44.6 µM 0.609563361562495 0.262707935664816 no 915 0.271075544100427 1340 1186886 SGTC_1936 st074407 74.3 µM 0.607297415099419 0.263463692381723 no 916 0.271826776741201 1330 809813 SGTC_1395 3486-0190 4.35 µM 0.605530692089118 0.264053713059271 no 917 0.272413218925275 1388 6748079 SGTC_911 3456-4043 236 µM 0.605272443329672 0.26414001503715 no 918 0.272498994066932 1414 914281 SGTC_268 camptothecin 39.6153 µM 0.60411515795692 0.264526934876207 no 919 0.272883541244839 1352 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_904 1141-0088 396 µM 0.60035191827677 0.265787104240666 no 920 0.274135862304203 1260 1378119 SGTC_3334 9142812 21.919 µM 0.598918793664659 0.266267803323632 no 921 0.274613519119438 1390 45283678 SGTC_1080 nisoldipine 24.4 µM 0.598550536849708 0.266391395160004 no 922 0.274736324450211 1316 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1995 st072814 61.1 µM 0.59803524744751 0.266564381777564 no 923 0.27490820726859 1280 5769371 SGTC_2489 cantharidin 73.42 µM 0.596961159208051 0.266925143984442 no 924 0.275266656421014 1310 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_263 alizarin 107.927 µM 0.59625624877201 0.267162041600794 no 925 0.275502027007141 1356 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_521 r062-0005 13.8 µM 0.596175361735504 0.267189231905871 no 926 0.275529041632347 1321 2832033 SGTC_1771 st048882 4.1505 µM 0.595419015367448 0.267443546506032 no 927 0.275781708965945 1290 4580403 SGTC_1600 coumarin 106 71.1 µM 0.59389797824052 0.267955350785549 no 928 0.27629017567381 1392 100336 A hepatotoxic, DNA x-linker. SGTC_881 0833-0569 170 µM 0.593364728833674 0.268134897239685 no 929 0.276468544169732 1305 5418700 SGTC_3138 9097216 49.47 µM 0.593323299710982 0.268148849066819 no 930 0.276482404308243 1336 25237486 SGTC_3116 9124943 49.47 µM 0.592027087578631 0.268585550790383 no 931 0.276916224882257 1265 41905195 YPL160W CDC60 SGTC_922 1866-0035 480 µM 0.591779913604857 0.268668865761384 no 932 0.276998987710315 1396 3156169 SGTC_3321 9137793 26.8275 µM 0.591625078130816 0.268721062793821 no 933 0.277050838420926 1344 4904192 SGTC_2744 captopril 92.04 µM 0.589786120952857 0.269341388255651 no 934 0.277667024356357 1388 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1708 st033234 31.827 µM 0.588337887414258 0.269830417919136 no 935 0.278152759853336 1425 674664 SGTC_232 clozapine 119 µM 0.588277519349061 0.269850812244783 no 936 0.278173016211607 1346 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2995 9067767 71.4286 µM 0.587221726175783 0.270207618763181 no 937 0.278527401325199 1363 11673567 SGTC_1035 k081-0041 55.2 µM 0.585997722175711 0.270621567425763 no 938 0.278938522776463 1362 731709 SGTC_294 k038-0071 157 µM 0.585747391799129 0.27070626621412 no 939 0.279022640702047 1350 24152826 SGTC_2714 st079313 56.9 µM 0.583183518614889 0.271574508926576 no 940 0.279884882473785 1366 2939799 SGTC_2667 digitoxin 100 µM 0.581935384523356 0.271997684527787 no 941 0.280305102587766 1340 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_50 0929-0078 56.389 µM 0.580263816954325 0.272564937013644 no 942 0.28086836191899 1387 1377751 SGTC_2483 5729050 27.16 µM 0.579676960798197 0.272764227964221 no 943 0.281066241441217 1447 2865180 SGTC_703 3875-0075 71.8 µM 0.579505932188119 0.272822321307955 no 944 0.281123922520045 1428 2850814 SGTC_925 2064-1272 59.6 µM 0.57903953819835 0.272980772688559 no 945 0.281281247524609 1353 6815817 SGTC_3339 9145883 14.936 µM 0.575432035438017 0.274207914659995 no 946 0.282499571721362 1348 2030670 SGTC_137 0438-0332 85.389 µM 0.574378812765875 0.274566696058238 no 947 0.28285574354562 1358 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2199 6590217 200 µM 0.573441538108305 0.27488617427224 no 948 0.283172886096845 1378 703109 SGTC_1303 1160-0052 261 µM 0.571185877979701 0.275655785813228 no 949 0.283936824974641 1393 3562476 SGTC_2976 9009005 19.48 µM 0.570301237765778 0.275957906257647 no 950 0.284236700767401 1460 2993148 SGTC_1664 st014217 9.02 µM 0.569915167376212 0.276089807152465 no 951 0.284367618547132 1421 3982782 SGTC_2724 maprotiline 69.64 µM 0.569421453261048 0.276258529598451 no 952 0.284535080654913 1396 4011 A tricyclic antidepressant. SGTC_2386 9075165 157.42 µM 0.56879997627468 0.276470985780248 no 953 0.284745945384139 1353 16452277 SGTC_1983 st071813 46.9 µM 0.568433981726441 0.276596141006778 no 954 0.284870160797929 1376 11838595 SGTC_3219 9131112 49.47 µM 0.566836306285423 0.277142805908349 no 955 0.285412700664134 1341 17612988 YMR079W SEC14 SGTC_950 1165-0508 94.1 µM 0.565948496465123 0.277446809625317 no 956 0.285714396342579 1355 6148369 SGTC_1060 3448-7350 82 µM 0.56592308298062 0.277455514106433 no 957 0.285723034590081 1452 570178 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.564018320664136 0.278108302055096 no 958 0.286370831948168 1388 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_320 4092-0846 5.34 µM 0.563807627427749 0.278180555483675 no 959 0.286442530156866 1429 1359356 SGTC_811 0416-0114 265 µM 0.563774011811321 0.278192084197097 no 960 0.286453970227455 1398 6612453 SGTC_2018 5133068 143 µM 0.56245793283503 0.278643625823489 no 961 0.286902028699041 1393 785362 SGTC_1579 chlormadinone acetate 49.4 µM 0.561083991396959 0.279115400276834 no 962 0.287370140405479 1461 45114258 A steroidal progestin. SGTC_1140 3229-1848 2.98 µM 0.560224228532092 0.279410817082536 no 963 0.287663251454136 1397 2849525 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.559601385675978 0.27962492236411 no 964 0.287875679756228 1458 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_594 1487-1584 10.8 µM 0.55926877037814 0.279739293111349 no 965 0.287989152676525 1347 5013332 SGTC_2854 9024559 71.43 µM 0.559198114420802 0.279763591292445 no 966 0.288013259932489 1358 3163529 SGTC_3214 9129694 49.47 µM 0.559186838958743 0.279767468954336 no 967 0.28801710711944 1444 17158655 SGTC_2814 7977482 42.97 µM 0.55822528020938 0.280098247503154 no 968 0.288345280108404 1494 6456762 SGTC_2269 7935389 174.42 µM 0.558033968048069 0.280164081952054 no 969 0.288410594576383 1361 97605 SGTC_3076 9116187 49.47 µM 0.557518699052069 0.280341433891941 no 970 0.288586543426185 1453 27241210 SGTC_762 1165-0429 115 µM 0.556863550736359 0.280567009782914 no 971 0.288810329848641 1500 5967793 SGTC_464 bw-b 70c 158 µM 0.555866273611202 0.280910553490137 no 972 0.289151137815224 1437 5353454 SGTC_3039 9090270 49.47 µM 0.555377354772122 0.281079051321277 no 973 0.289318289244244 1417 17173750 SGTC_827 3253-0474 693 µM 0.553904040840369 0.281587099769007 no 974 0.289822259762162 1445 5402065 SGTC_657 3534-0529 86.7 µM 0.552406250483511 0.2821040420698 no 975 0.290335024582376 1488 1049549 SGTC_131 0141-0277 33.849 µM 0.552214624105866 0.282170212304371 no 976 0.290400658039469 1465 1547771 SGTC_1887 st057648 70.8 µM 0.550828271134117 0.282649154313849 no 977 0.290875701014732 1485 688672 SGTC_392 N-ethylmaleimide 8.33 µM 0.550827251801769 0.282649506605292 no 978 0.290876050429263 1370 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1830 st055982 50.3 µM 0.549565619382285 0.283085701064628 no 979 0.291308672743606 1411 455313 An antimicrobial agent. SGTC_1338 1486-1223 76 µM 0.548428011940139 0.283479292126703 no 980 0.291699023331377 1484 3444526 SGTC_331 k048-0133 24.5 µM 0.547234185318723 0.283892615815122 no 981 0.292108926535424 1390 6813582 SGTC_176 1486-1328 72.834 µM 0.546309217079343 0.284213054210181 no 982 0.2924267007763 1399 22310231 SGTC_1866 st057638 64 µM 0.543803815232846 0.285081872539041 no 983 0.293288241562829 1425 688802 SGTC_266 formosanin C 406 nM 0.543389919124444 0.285225524390083 no 984 0.293430682534672 1424 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2035 5154463 94.595 µM 0.541808211075902 0.285774808880563 no 985 0.293975317131908 1474 2769623 SGTC_230 MPP+ 141.667 µM 0.541541694598595 0.285867412362028 no 986 0.294067133598638 1365 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_935 2996-0153 430 µM 0.541383772444308 0.285922290527056 no 987 0.294121544946765 1443 23738523 SGTC_11 0438-0307 1.3 µM 0.54110408256855 0.286019495429731 no 988 0.29421792221554 1487 4011476 SGTC_1749 st037932 54.2 µM 0.538924510814478 0.286777532893364 no 989 0.294969471884169 1423 594497 SGTC_1891 st059073 26.2 µM 0.538845452525247 0.28680504661663 no 990 0.29499674900739 1531 688754 SGTC_923 1900-2434 73.3 µM 0.538796356533908 0.286822133544724 no 991 0.295013688959664 1380 5910570 SGTC_2839 9003951 25.97 µM 0.538604407223857 0.286888942489603 no 992 0.29507992294746 1432 2990634 SGTC_1025 k007-0731 70 µM 0.538552380589603 0.286907051897384 no 993 0.295097876426385 1404 6256118 SGTC_778 3456-2434 196 µM 0.538297818168984 0.286995667679446 no 994 0.295185728704365 1573 5539063 SGTC_2842 9000675 19.48 µM 0.538007944521298 0.287096591444647 no 995 0.295285781933214 1373 2989072 SGTC_2720 fluspirilene 36.88 µM 0.53682575846887 0.287508360794213 no 996 0.295693988598852 1443 3396 An atypical antipsychotic. SGTC_2619 obliquin 87.91 µM 0.535837652330427 0.287852743923539 no 997 0.29603537866354 1451 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2450 5739737 12.93 µM 0.535657508415237 0.287915550199204 no 998 0.29609763776863 1422 2262825 SGTC_2918 7977171 22.06 µM 0.53559641983623 0.287936849896044 no 999 0.296118751809644 1401 2236483 SGTC_2030 5175110 200 µM 0.535551183624351 0.287952622842515 no 1000 0.296134387243383 1486 2831986 SGTC_630 4356-0227 183 µM 0.534534270776534 0.288307307270528 no 1001 0.296485972690004 1449 779312 SGTC_2576 guaiol 23.12 µM 0.534167836619252 0.288435164654738 no 1002 0.296612709780985 1482 227829 SGTC_2044 5102272 200 µM 0.533566980852957 0.28864487500356 no 1003 0.29682057900831 1430 592666 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.532528295970546 0.289007565512728 no 1004 0.297180074701827 1439 77254 SGTC_2988 9073640 71.4286 µM 0.532154827174255 0.289138026634976 no 1005 0.297309383347732 1480 9102229 SGTC_2837 9008476 45.46 µM 0.53107226372008 0.28951634699471 no 1006 0.297684351849534 1459 2992805 SGTC_1879 gemcitabine 100 µM 0.529695978499098 0.289997648811859 no 1007 0.29816136832584 1443 60750 A nucleoside analog which inhibits DNA replication. SGTC_876 0720-0963 56.8 µM 0.528275277606766 0.290494876396556 no 1008 0.298654144037134 1557 765861 SGTC_1917 st066507 28.5 µM 0.527219025631237 0.290864809817877 no 1009 0.299020749029828 1449 3156428 SGTC_1306 1185-0270 9.02 µM 0.52688278617328 0.290982617882001 no 1010 0.299137494221784 1475 1548076 SGTC_626 0214-0009 33 µM 0.526543037019194 0.291101678276544 no 1011 0.299255479019224 1536 3437874 SGTC_1933 st074711 15.9 µM 0.525303616390394 0.291536208883354 no 1012 0.299686071904629 1402 17250958 SGTC_2091 4-phenylthiadiazole 200 µM 0.525098903607501 0.291608008585438 no 1013 0.2997572191225 1456 270010 SGTC_1402 3909-7673 35.9 µM 0.524897887113237 0.291678519895176 no 1014 0.299827089150528 1410 5328014 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.522523698508672 0.292511923520583 no 1015 0.300652875280141 1468 368090 SGTC_687 k029-0044 34.9 µM 0.519912354966673 0.293429850825035 no 1016 0.301562331880852 1542 5829338 SGTC_113 0099-0221 2.5 µM 0.519819926943034 0.293462365130966 no 1017 0.301594544596905 1538 89219 SGTC_3175 9106517 49.47 µM 0.519268966202632 0.293656216570779 no 1018 0.301786595757248 1413 41468073 SGTC_2941 9056145 11.23 µM 0.518670546666635 0.293866833162455 no 1019 0.301995252124924 1388 2119517 SGTC_1021 4476-0760 85.3 µM 0.517974393520063 0.294111935444966 no 1020 0.302238067658708 1424 746768 SGTC_400 oxethazaine 37.5 µM 0.517890214216757 0.294141579778316 no 1021 0.30226743501179 1446 4621 A local anesthetic. SGTC_895 0964-0006 13.7 µM 0.517842511533194 0.294158379226515 no 1022 0.302284077456418 1430 6738897 SGTC_484 loperamide 105 µM 0.516885916761987 0.294495356636342 no 1023 0.30261789963076 1448 3955 An opioid-receptor agonist. SGTC_2717 st081029 62.2815 µM 0.516337380765447 0.294688668470435 no 1024 0.302809396328556 1439 5292846 SGTC_584 0986-0246 15.4 µM 0.515152022030518 0.295106605384651 no 1025 0.30322339628266 1526 53315 YDR232W HEM1 SGTC_565 1418-0001 44.5 µM 0.514928576318926 0.295185419031322 no 1026 0.303301465567046 1511 2862145 SGTC_788 1182-0090 188 µM 0.513486000184398 0.295694476756762 no 1027 0.303805700659161 1610 5715185 SGTC_1756 st041558 35.5 µM 0.513158901886324 0.29580995962182 no 1028 0.303920085919288 1622 3955792 SGTC_912 3474-0017 2.18 µM 0.511558282784868 0.296375360673579 no 1029 0.304480094158385 1557 3360550 SGTC_893 0958-0369 48.9 µM 0.509763411029067 0.29700996794622 no 1030 0.305108611091905 1564 6819948 SGTC_1098 clofazimine 15.1 µM 0.509187306524738 0.297213791124319 no 1031 0.305310469794658 1504 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_496 calpeptin 138 µM 0.508173541348557 0.29757261181966 no 1032 0.305665822248213 1413 73364 A calpain inhibitor. SGTC_1174 0739-0097 51.1 µM 0.507668632590533 0.297751397271506 no 1033 0.305842874921835 1468 728447 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.506882778784746 0.298029761281966 no 1034 0.306118534834184 1550 5024745 SGTC_1924 st058459 75.1 µM 0.506798171027904 0.298059737990846 no 1035 0.306148219891066 1459 688683 SGTC_599 1935-0052 86.5 µM 0.505877140866495 0.298386149788972 no 1036 0.306471450269161 1447 9557311 SGTC_139 0099-0334 718.624 µM 0.50428036479411 0.298952430169992 no 1037 0.30703218673377 1491 97690 SGTC_445 e6 berbamine 66 µM 0.502443911790724 0.299604312371178 no 1038 0.30767764846003 1485 6610268 A calcium/calmodulin antagonist. SGTC_2078 5212016 200 µM 0.502214456064887 0.299685807076536 no 1039 0.307758337621175 1486 1899708 SGTC_2195 6536160 144.242 µM 0.50166493086148 0.299881020153995 no 1040 0.307951618481962 1383 3834386 SGTC_3099 9120367 49.47 µM 0.500990762700721 0.300120589930791 no 1041 0.308188811972568 1465 24824940 SGTC_534 k292-0788 63.4 µM 0.500890151637582 0.300156350108655 no 1042 0.308224216971355 1538 4146317 SGTC_2272 7805186 180 µM 0.500770062448135 0.30019903591687 no 1043 0.308266478651992 1476 2956062 YPR165W RHO1 SGTC_3041 9091929 49.47 µM 0.499537857296833 0.300637182793492 no 1044 0.30870026194161 1523 25236887 SGTC_2831 7999036 19.48 µM 0.499514532309037 0.300645479463995 no 1045 0.308708475805794 1651 2988270 SGTC_359 0081-0058 15.9 µM 0.498781478202761 0.300906278587696 no 1046 0.308966668607277 1640 3494159 SGTC_2772 vinpocetine 57.06 µM 0.498615685102431 0.300965277047702 no 1047 0.309025076554063 1530 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1415 3966-0071 78.1 µM 0.498287987804107 0.301081905418122 no 1048 0.309140536612772 1477 2893185 SGTC_2126 5251174 33.877 µM 0.496786327913823 0.301616610630561 no 1049 0.309669868781585 1648 790722 SGTC_2325 6158266 200 µM 0.495935251481173 0.301919848125544 no 1050 0.30997004700218 1473 3623240 SGTC_2471 5466956 24.79 µM 0.495360140219906 0.302124837085646 no 1051 0.310172962912254 1511 724419 SGTC_2462 5162487 171.77 µM 0.495114987641648 0.302212236684216 no 1052 0.310259477420706 1488 2259986 SGTC_903 1134-0042 114 µM 0.49407933393669 0.302581583808163 no 1053 0.310625076149533 1465 701009 SGTC_1502 4534-4282 27.7 µM 0.493808069770496 0.302678358680825 no 1054 0.310720866734608 1493 3278949 SGTC_1716 st033144 30.6155 µM 0.492930179171936 0.302991645634675 no 1055 0.311030961169221 1579 674617 SGTC_707 0865-0008 204 µM 0.491923878980052 0.303350935648022 no 1056 0.311386578398222 1569 723043 SGTC_2981 9013952 38.96 µM 0.491834445307877 0.303382876309831 no 1057 0.31141819195906 1383 2996344 SGTC_455 paf C-16 10 µM 0.487840155249815 0.304810940718803 no 1058 0.312831533131318 1496 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1504 k297-0033 30 µM 0.486289547500472 0.305366127941105 no 1059 0.313380944537755 1426 4388117 SGTC_613 3914-0030 117 µM 0.484797221959612 0.305900870632513 no 1060 0.313910096764952 1433 1145395 SGTC_1588 farnesol 29.9 µM 0.484619636775261 0.305964532042964 no 1061 0.31397309084413 1487 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1232 0279-0259 161 µM 0.484021018617809 0.306179170126816 no 1062 0.314185476189937 1490 1560000 SGTC_3301 9125354 19.7965 µM 0.483780233586206 0.306265523796725 no 1063 0.314270922318951 1478 41905162 SGTC_690 glyoxal 20.3 µM 0.483762331576063 0.306271944493988 no 1064 0.314277275509561 1409 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2780 5215298 71.43 µM 0.48263950991028 0.306674772172355 no 1065 0.314675860201366 1571 2834131 SGTC_211 3455-0679 143.504 µM 0.482322845942772 0.306788421972794 no 1066 0.314788310191683 1514 748649 SGTC_121 0557-0495 61.343 µM 0.480810855770491 0.307331326896665 no 1067 0.31532546704012 1558 3104427 SGTC_469 w7 172 µM 0.479320113844894 0.307867015948253 no 1068 0.315855457588075 1542 45115570 A P450 inhibitor. SGTC_3254 9136651 49.47 µM 0.479156824596363 0.307925717866351 no 1069 0.315913533435462 1480 16454030 SGTC_1680 diphenhydramine 100 µM 0.477761149553239 0.308427658636552 no 1070 0.316410107865728 1502 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2435 5706476 10.6 µM 0.476378187299218 0.308925380842886 no 1071 0.31690248586339 1578 5725375 SGTC_2932 9016711 44.54 µM 0.476004835413661 0.309059808809167 no 1072 0.317035466516513 1632 7117328 SGTC_2240 6690706 185.951 µM 0.475018322474288 0.3094151327402 no 1073 0.317386956862744 1434 805876 SGTC_1849 st056239 19.2 µM 0.474577264275105 0.309574051530595 no 1074 0.31754415732584 1417 5393181 SGTC_1707 st032323 6.317 µM 0.473163676235151 0.310083624846332 no 1075 0.318048205199616 1520 3132057 YMR211W DML1 SGTC_1054 3429-0080 167 µM 0.472930903671542 0.310167570232521 no 1076 0.318131238061087 1583 1162877 SGTC_2621 lithochol-11-enic acid 100 µM 0.472404396007527 0.31035748257851 no 1077 0.318319083594106 1635 6708711 SGTC_683 panaxydol 45 µM 0.472016247340173 0.310497520952044 no 1078 0.318457595820298 1573 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_301 4119-0100 24.5 µM 0.47132626910935 0.310746522834326 no 1079 0.31870387964037 1549 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2 0422-0095 29 µM 0.470947745907994 0.31088316251922 no 1080 0.318839025385736 1446 6790840 SGTC_848 0368-0089 85.6 µM 0.470109235639202 0.311185941656083 no 1081 0.319138488047579 1542 762535 SGTC_1999 st074831 12.5 µM 0.469369568143581 0.311453135594503 no 1082 0.319402748360509 1484 17112523 SGTC_2944 9067346 25.62 µM 0.469332818874167 0.311466413315781 no 1083 0.319415880131243 1561 6473075 SGTC_15 0266-0086 27.098 µM 0.469062203702911 0.311564195675683 no 1084 0.319512587160531 1579 1712902 YIL048W NEO1 SGTC_2157 5649910 96.377 µM 0.469022608630192 0.311578503821464 no 1085 0.319526737884146 1474 2858091 SGTC_157 1348-1695 65.819 µM 0.468758562676569 0.311673927210395 no 1086 0.319621110923153 1492 5380510 SGTC_89 0302-0250 142.109 µM 0.467399564792185 0.312165254487852 no 1087 0.320107016956972 1591 4203518 YLR208W SEC13 SGTC_59 0330-0160 1.33 µM 0.467091089308951 0.312276826201437 no 1088 0.320217354554602 1522 4293482 SGTC_1314 1222-0010 41.1 µM 0.465679596275038 0.312787565022561 no 1089 0.320722429623897 1544 3526027 SGTC_2785 7756463 72.73 µM 0.463834281403717 0.313455821549424 no 1090 0.32138324008519 1475 2201551 SGTC_385 1494-0393 12.4 µM 0.463265518143317 0.313661915339016 no 1091 0.321587029358585 1557 3090647 SGTC_2644 guaiazulene 100 µM 0.463127129496889 0.313712069855412 no 1092 0.321636622475603 1584 3515 A coloring agent. SGTC_2289 7946404 165.07 µM 0.459212945076574 0.315132063200918 no 1093 0.323040627730682 1518 1246120 YPR165W RHO1 SGTC_342 k048-0088 23.3 µM 0.459110814209945 0.31516915109635 no 1094 0.323077295628291 1497 6820570 SGTC_2140 5586273 200 µM 0.458974058277672 0.315218815687086 no 1095 0.323126397605736 1529 854421 SGTC_2127 5253358 187.912 µM 0.457136594083259 0.315886436901733 no 1096 0.323786434516975 1482 20612 SGTC_706 4262-0057 46.9 µM 0.456186626203812 0.31623183250563 no 1097 0.324127890813867 1498 883298 SGTC_783 0848-0141 92.7 µM 0.455448204761506 0.316500423482461 no 1098 0.324393411144413 1499 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1520 flindersine 88 µM 0.455152148677973 0.31660813713927 no 1099 0.324499891578014 1703 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2008 4012253 172 µM 0.454601195963701 0.316808630869798 no 1100 0.324698087104454 1520 603940 SGTC_184 1494-0393 24.714 µM 0.453792479078582 0.317103023399134 no 1101 0.324989098655523 1500 3090647 SGTC_2541 muurolladie-3-one 83.07 µM 0.452722835146323 0.317492577539278 no 1102 0.325374167168999 1575 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2027 5150920 200 µM 0.450838092792027 0.318179474626352 no 1103 0.326053122245192 1606 786715 SGTC_1250 0485-0349 40.2 µM 0.449958580061992 0.318500228613151 no 1104 0.32637015343152 1540 6842794 YDL195W SEC31 SGTC_393 acivicin 6.25 µM 0.448656882594036 0.318975201002912 no 1105 0.326839596545357 1545 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1239 0337-0584 35.4 µM 0.448421810529399 0.319061007452959 no 1106 0.326924401996019 1707 914301 YML130C ERO1 SGTC_1313 1220-0047 237 µM 0.448153051475573 0.319159122271677 no 1107 0.327021371440306 1610 3528706 SGTC_2626 ethyl orsellinate 100 µM 0.446104056274521 0.319907557009833 no 1108 0.327761041455354 1519 75653 A natural product. SGTC_748 act1.228 77.9 µM 0.445954561864683 0.319962191459357 no 1109 0.327815034184579 1486 4421505 YNR035C ARC35 SGTC_1139 k015-0024 46.9 µM 0.444893917631055 0.320349928162418 no 1110 0.328198209191754 1603 2766652 SGTC_1474 0330-0125 5.35 µM 0.444574134101254 0.320466869034647 no 1111 0.328313771700405 1528 X1474 SGTC_3090 9117696 49.47 µM 0.443164800566003 0.320982457112013 no 1112 0.328823268489167 1670 7923821 SGTC_1935 st074532 41.6 µM 0.442624851418296 0.321180082713468 no 1113 0.3290185531919 1709 2829742 SGTC_1620 st003704 16.5 µM 0.442593266950763 0.321191644443676 no 1114 0.329029977867507 1580 2834414 SGTC_2172 5754775 163.918 µM 0.440817821730956 0.321841837838359 no 1115 0.329672445196491 1508 2263357 SGTC_1816 st051957 91.6 µM 0.43859426853392 0.322656904620347 no 1116 0.33047777535822 1576 674121 SGTC_3239 9133757 49.47 µM 0.438262633476082 0.322778542115261 no 1117 0.33059795490536 1617 17036923 SGTC_2484 5809818 12.04 µM 0.437008251935486 0.323238797075463 no 1118 0.331052681777272 1586 2870548 SGTC_3242 9133940 49.47 µM 0.43684006221779 0.323300529478375 no 1119 0.331113671338406 1598 17248444 SGTC_1459 k035-0031 35.7 µM 0.435894279414191 0.323647760439775 no 1120 0.331456717915398 1464 3877128 YMR208W ERG12 SGTC_2534 helenine 20.12 µM 0.432716598962661 0.324815524986704 no 1121 0.332610334692897 1583 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3246 9135460 32.98 µM 0.432398504932455 0.324932516332827 no 1122 0.332725902274048 1623 41446951 SGTC_1567 st069303 68.4 µM 0.430082696231856 0.325784764114931 no 1123 0.333567743386033 1573 5581319 SGTC_1973 st070275 50.2 µM 0.429753898994333 0.325905839757049 no 1124 0.333687335613691 1581 17118334 SGTC_2399 5884133 200 µM 0.428279536386082 0.326448981724485 no 1125 0.334223807825949 1549 722445 SGTC_567 1080-0542 68.4 µM 0.427957236492153 0.326567763193756 no 1126 0.334341127356959 1646 5950415 SGTC_372 0155-0182 15.9 µM 0.42770969084324 0.326659006427048 no 1127 0.334431246781804 1657 771486 SGTC_1223 0764-0573 147 µM 0.427211923164548 0.326842510768849 no 1128 0.334612488852904 1572 1609797 SGTC_3071 9117417 49.47 µM 0.426706740290774 0.327028791585563 no 1129 0.334796470279966 1674 45595590 YGL055W OLE1 SGTC_2415 st077333 57.7 µM 0.426224369365632 0.327206700969714 no 1130 0.334972180892791 1834 2766255 SGTC_752 1896-0090 130 µM 0.424404136164386 0.327878397799293 no 1131 0.335635552383666 1590 772567 SGTC_2457 5731572 11.68 µM 0.424247637487997 0.327936174499725 no 1132 0.33569261121072 1717 2865357 SGTC_919 tnp00227 403.569 nM 0.423455324606358 0.328228746375466 no 1133 0.335981543617077 1617 1269246 A methoxyflavone. YNL221C POP1 SGTC_2013 4024628 200 µM 0.421677091058862 0.328885765839019 no 1134 0.336630364065798 1629 5230760 SGTC_790 1575-0012 79.1 µM 0.420260350724497 0.329409600088247 no 1135 0.337147635646953 1640 378741 YLR208W SEC13 SGTC_1479 0549-0158 134 µM 0.41927528657463 0.32977402124348 no 1136 0.33750747787808 1597 5440202 SGTC_2290 7904846 200 µM 0.418313992861697 0.330129804468132 no 1137 0.337858780124834 1575 2962154 SGTC_2206 7254556 146.969 µM 0.417719376958105 0.330349953970713 no 1138 0.338076151682607 1666 4398905 SGTC_3067 9117431 49.47 µM 0.416955762208552 0.330632759433577 no 1139 0.338355382720156 1606 17150885 SGTC_731 3966-0296 387 µM 0.416048365093436 0.330968940583339 no 1140 0.338687306260381 1610 660956 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.415725464861008 0.331088604650274 no 1141 0.338805452585279 1600 521171 SGTC_1798 st045719 60.953 µM 0.413601870044047 0.331876020158597 no 1142 0.339582851741219 1621 3980186 SGTC_398 bronopol 33.3 µM 0.412014555762918 0.332465071858544 no 1143 0.340164377230715 1645 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1677 st019204 53.9 µM 0.411627915707933 0.332608616586608 no 1144 0.340306083624303 1538 3945625 SGTC_373 0844-0104 25.9 µM 0.411581808546264 0.332625736058398 no 1145 0.340322983740106 1728 5375804 SGTC_2508 celastrol 40.54 µM 0.410546519966344 0.333010227927037 no 1146 0.340702542736939 1552 122724 Celastrol is a natural product and antioxidant. SGTC_1075 aripiprazole 15.2 µM 0.40949385240178 0.333401354191436 no 1147 0.341088638685882 1597 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2046 4110841 106 µM 0.408046664576252 0.333939363056655 no 1148 0.341619707896881 1656 44119630 YMR134W ERG29 SGTC_2969 9091408 28.7 µM 0.406840685452518 0.334387960722859 no 1149 0.342062501302783 1542 4286311 SGTC_2277 7947813 106.88 µM 0.406780837996072 0.33441022882534 no 1150 0.342084480862133 1719 1246798 SGTC_2892 9047358 58.44 µM 0.406309262105085 0.334585713640758 no 1151 0.342257690400466 1595 6466771 SGTC_2334 9017922 200 µM 0.406097908023093 0.3346643753472 no 1152 0.342335331399808 1765 3163164 SGTC_488 nitrendipine 139 µM 0.403963989989059 0.335458982405867 no 1153 0.343119599789017 1673 4507 Dihydropyridine L-type calcium channel blocker. SGTC_3154 9100113 49.47 µM 0.401765403652621 0.336278440464748 no 1154 0.343928342776173 1576 25237525 SGTC_2011 4012611 177 µM 0.399967546939911 0.33694911722288 no 1155 0.344590209960239 1581 2049887 SGTC_2502 avocadyne acetate 18.59 µM 0.399948479500106 0.336956232969598 no 1156 0.344597232046898 1592 3952079 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.399584564202616 0.337092053106754 no 1157 0.344731263697089 1598 279621 SGTC_311 1315-0136 58 µM 0.399325220684479 0.337188858021697 no 1158 0.344826792983709 1707 6759207 SGTC_2557 derrustone 83.84 µM 0.397129941729625 0.338008719083408 no 1159 0.345635820637007 1571 629853 An antioxidant. SGTC_3196 9111891 49.47 µM 0.397129457786011 0.338008899904592 no 1160 0.345635999062992 1610 18891510 SGTC_2285 7945142 200 µM 0.396639323202702 0.338192053470023 no 1161 0.345816725205715 1629 2970608 SGTC_3069 9117009 49.47 µM 0.395583984610219 0.338586542520185 no 1162 0.346205976891537 1624 41904981 SGTC_1997 st073024 93.8 µM 0.395131004357427 0.338755922404195 no 1163 0.346373104261787 1705 686268 SGTC_185 k048-0037 25.491 µM 0.392734570174639 0.339652547000298 no 1164 0.347257767365297 1750 6827589 SGTC_2076 5212012 200 µM 0.392527286289538 0.339730144903338 no 1165 0.34733432709539 1632 604802 SGTC_1611 st001856 99.4 µM 0.389904901206233 0.340712435314687 no 1166 0.348303434772782 1599 647478 SGTC_1169 aniline yellow 25.8 µM 0.388574165433753 0.341211314978165 no 1167 0.348795590397895 1710 6051 A DNA damaging agent. SGTC_879 0831-1030 162 µM 0.388269781007736 0.341325464736674 no 1168 0.348908198887688 1619 1549252 SGTC_3142 9086498 49.47 µM 0.386590491291844 0.341955490040741 no 1169 0.349529699257866 1750 25236367 SGTC_470 aa-861 153 µM 0.386150163180682 0.342120762499171 no 1170 0.34969273029609 1612 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_124 0136-0217 7.121 µM 0.384228995042978 0.342842206018408 no 1171 0.350404364851641 1727 3976905 SGTC_1017 4239-0030 168 µM 0.384101607961466 0.342890063144798 no 1172 0.350451569874988 1570 1149593 SGTC_1534 6-azauridine 81.6 µM 0.382725886276427 0.343407058502096 no 1173 0.350961509370813 1655 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2916 7875993 68.79 µM 0.377200012424711 0.345486623499309 no 1174 0.353012485529618 1818 1299250 SGTC_1959 st077091 55.8 µM 0.37601825984468 0.345931963796085 no 1175 0.353451660565696 1648 821356 YKL052C ASK1 SGTC_3277 9138724 49.47 µM 0.374190523281789 0.346621161151567 no 1176 0.354131287026118 1673 15943418 SGTC_3245 9134821 49.47 µM 0.37400629917653 0.346690656035319 no 1177 0.354199814835193 1574 17014901 SGTC_1 0258-0098 57.368 µM 0.372735129689127 0.347170319975924 no 1178 0.354672793922959 1654 6790032 YDR047W HEM12 SGTC_164 4100-3994 89.624 µM 0.368082742557046 0.348927938470348 no 1179 0.356405769206343 1810 4615967 SGTC_2663 amphotericin b 100 µM 0.367993362506721 0.348961737129999 no 1180 0.356439091710492 1683 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1863 st057641 20.1 µM 0.365505446479798 0.349903011326877 no 1181 0.357367070969922 1764 3921635 SGTC_2873 9040596 71.43 µM 0.364389312297509 0.350325588093319 no 1182 0.35778365762596 1625 6463863 SGTC_523 1934-0222 13.7 µM 0.364372577680103 0.350331925356479 no 1183 0.357789904956149 1645 1361595 SGTC_2316 5844804 197.44 µM 0.363460914790899 0.350677227582215 no 1184 0.358130302445255 1820 776813 SGTC_1173 0443-0020 122 µM 0.360952417571991 0.351627984329563 no 1185 0.35906750884927 1658 5331295 SGTC_2320 7373003 200 µM 0.360297243206473 0.35187645811443 no 1186 0.359312430342695 1610 5415828 SGTC_2682 pyrogallin 40.03 µM 0.358895711796141 0.352408198898859 no 1187 0.359836553853668 1735 822798 An ATP competetive kinase inhibitor. SGTC_615 k087-0205 167 µM 0.35808309877339 0.352716636390108 no 1188 0.360140563406719 1618 9642773 SGTC_2688 kanamycin b 96.69 µM 0.356447065690858 0.353337906894106 no 1189 0.360752893765357 1686 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2406 ethylparaben 405.7 µM 0.355617804484342 0.353652961654809 no 1190 0.361063404069395 1465 8434 A possible steroid mimic. SGTC_77 0828-0286 12.516 µM 0.353544841849498 0.354440964439743 no 1191 0.361840008747016 1619 745345 SGTC_315 k915-0449 187 µM 0.353289073445693 0.354538233885249 no 1192 0.36193586810093 1745 20970215 YNL149C PGA2 SGTC_2984 9022109 38.96 µM 0.352508450867048 0.354835165494292 no 1193 0.362228490914927 1728 6459207 SGTC_3271 9137798 49.47 µM 0.352494591744259 0.354840437996308 no 1194 0.362233686849497 1810 6498326 SGTC_1312 1218-2183 165 µM 0.352234866594596 0.354939251799831 no 1195 0.362331065302881 1748 6744073 SGTC_482 fipronil 114 µM 0.351364988653756 0.355270272492035 no 1196 0.362657272498399 1741 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_3157 9099274 49.47 µM 0.350397903911125 0.355638412185845 no 1197 0.363020049623091 1832 17217662 SGTC_1128 3448-9350 235 µM 0.350214115942805 0.355708389907456 no 1198 0.363089006894809 1680 619386 SGTC_1398 3558-0053 112 µM 0.349177135092657 0.356103313985524 no 1199 0.363478165370698 1699 4532369 SGTC_1026 k007-1105 30.6 µM 0.34897925835852 0.356178690974279 no 1200 0.363552440633057 1703 7066794 SGTC_3184 9108758 49.47 µM 0.347975087504788 0.356561295363801 no 1201 0.363929446488373 1698 902885 SGTC_1893 st059353 36.1 µM 0.347803067148084 0.356626852236173 no 1202 0.363994043030596 1665 3112488 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.346309762411729 0.357196127724553 no 1203 0.364554966340869 1647 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.344753739546753 0.357789650880118 no 1204 0.365139756851629 1697 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1192 1488-0095 21.4 µM 0.34403723478941 0.358063067356268 no 1205 0.365409142020252 1721 915875 SGTC_2000 st075254 36.4 µM 0.343591776128314 0.358233090017233 no 1206 0.365576655144661 1679 17234175 SGTC_1986 st071812 45 µM 0.34294689874072 0.358479276621895 no 1207 0.365819204383001 1711 11838594 SGTC_887 0885-0007 9.62 µM 0.342748958279266 0.358554853628396 no 1208 0.365893663886475 1777 5719458 SGTC_173 1273-0061 2.693 µM 0.34268469364251 0.358579392141975 no 1209 0.365917839479282 1635 2847414 YPL266W DIM1 SGTC_994 3910-0338 138 µM 0.342547321446686 0.358631847667808 no 1210 0.365969519052524 1789 3479481 SGTC_3347 9188721 44.724 µM 0.339805431651575 0.359679394013339 no 1211 0.367001528600528 1758 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2302 7771753 200 µM 0.339135275838157 0.359935589602181 no 1212 0.367253912574072 1652 2203047 SGTC_2678 equilin 100 µM 0.337206143609401 0.360673433514301 no 1213 0.36798075315744 1830 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_472 calcifediol 10 µM 0.336467947850125 0.360955912022663 no 1214 0.368259008974239 1746 5283731 A vitamin D metabolite. SGTC_2377 9073351 62.6 µM 0.334996333408275 0.361519267257471 no 1215 0.368813926049419 1678 7337946 YHR072W ERG7 SGTC_2967 9089538 49.85 µM 0.334591917566934 0.361674136136388 no 1216 0.368966471344115 1909 728216 SGTC_1786 berberine 21.6 µM 0.333669469188891 0.362027467555174 no 1217 0.369314495256359 1667 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1837 st055472 66.5 µM 0.33274368539578 0.362382194821635 no 1218 0.369663885280571 1785 676091 SGTC_1031 k035-0009 16 µM 0.330919473181047 0.363081513403069 no 1219 0.370352656214823 1853 5180959 SGTC_2693 st077581 40.7 µM 0.330110229673824 0.3633918863235 no 1220 0.370658336971509 1770 25238761 SGTC_1259 0671-0132 43 µM 0.328984249422802 0.363823887962351 no 1221 0.371083796572047 1721 X1259 SGTC_1696 st025591 34.7925 µM 0.328823539297758 0.363885561292412 no 1222 0.371144534895463 1728 2787147 SGTC_875 0709-0210 25.7 µM 0.32866316396098 0.363947109661023 no 1223 0.371205149889759 1858 6251364 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.327804216010665 0.364276813853054 no 1224 0.371529849698003 1704 6708561 SGTC_914 3820-6779 408 µM 0.326843381842363 0.364645745753938 no 1225 0.371893172910356 1688 2893481 SGTC_1832 st054113 55 µM 0.326709331286746 0.364697227177462 no 1226 0.371943870941787 1851 1251267 SGTC_3349 9149703 23.001 µM 0.326468985473352 0.364789536854416 no 1227 0.372034775486871 1708 4910494 SGTC_100 0086-0128 49.5915 µM 0.326316612992154 0.364848062651964 no 1228 0.372092410104842 1644 93297 SGTC_3047 9092122 49.47 µM 0.326151816268286 0.364911364107552 no 1229 0.372154747396096 1704 17173831 SGTC_1346 1488-2224 62.4 µM 0.325096067222031 0.365316984043469 no 1230 0.372554182672266 1866 3722427 SGTC_651 3253-0966 34.4 µM 0.323332557480524 0.365994862331325 no 1231 0.373221699876644 1727 781462 SGTC_2808 7946468 45.46 µM 0.32286541955388 0.366174496417147 no 1232 0.373398583061239 1779 2970879 SGTC_627 1391-0720 175 µM 0.322351077236453 0.366372316495353 no 1233 0.373593371189659 1749 997839 SGTC_2899 9053889 58.44 µM 0.322102561579257 0.366467910288732 no 1234 0.373687498878583 1882 6470052 SGTC_3207 9114163 49.47 µM 0.320108307073828 0.367235317854271 no 1235 0.374443114300963 1916 849233 SGTC_3285 9112818 20.8695 µM 0.316743883265094 0.368531180688145 no 1236 0.37571897393179 1764 17017947 YPR165W RHO1 SGTC_3252 9135871 49.47 µM 0.316699259670966 0.368548378283798 no 1237 0.375735905298589 1814 17682838 SGTC_170 4197-0004 226 µM 0.316386816113483 0.368668799041757 no 1238 0.37585446131397 1818 218692 SGTC_1944 st076371 56.9 µM 0.316146743244217 0.368761335738674 no 1239 0.37594556439517 1700 24208455 SGTC_64 000l-0018 272.079 µM 0.315514766224697 0.36900496925463 no 1240 0.376185420684843 1722 6811119 SGTC_2696 st077691 74.316 µM 0.311966313055324 0.37037390876925 no 1241 0.377533062433771 1779 757133 SGTC_2191 5911152 200 µM 0.310714910302775 0.370857073860694 no 1242 0.378008680582039 1767 2875902 SGTC_140 0062-0056 502.533 µM 0.310676042289178 0.370872084019322 no 1243 0.378023456035693 1697 3758964 SGTC_1717 st033143 58.0435 µM 0.310639680882893 0.370886126347201 no 1244 0.378037278778409 1871 674616 SGTC_1994 st072947 40.9 µM 0.310618323268904 0.370894374475199 no 1245 0.378045397921204 1815 5286565 YDL195W SEC31 SGTC_3262 9137218 49.47 µM 0.310445782120211 0.370961010567403 no 1246 0.378110991784154 1778 17650664 SGTC_2915 7971052 15.16 µM 0.309410338455771 0.371360984344256 no 1247 0.378504703517507 1837 5741558 SGTC_2397 5161689 200 µM 0.308853571551536 0.371576111137608 no 1248 0.378716457859866 1826 2259942 SGTC_2356 9061756 188.97 µM 0.308825037637257 0.371587137316444 no 1249 0.378727311103234 1893 20104043 SGTC_2524 avocatin b 10.57 µM 0.308335668239977 0.37177625760853 no 1250 0.378913463962202 1868 6710748 SGTC_2662 daunorubicin 22.37 µM 0.308209621720811 0.371824974198243 no 1251 0.378961415769548 1769 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2700 st077718 96.8 µM 0.308171666882736 0.371839644027829 no 1252 0.378975855272501 1720 904970 SGTC_1324 1418-0026 34.4 µM 0.307276601637946 0.372185647350261 no 1253 0.379316421967458 1811 1372513 SGTC_129 0088-0017 176.636 µM 0.307255051502729 0.372193979210285 no 1254 0.37932462281423 1881 182446 SGTC_2369 9071472 200 µM 0.306678325128116 0.372416979304155 no 1255 0.379544114666785 1812 17296037 SGTC_3023 9089636 49.47 µM 0.305609222180958 0.372830477461404 no 1256 0.379951098973903 1873 17249241 SGTC_1358 1509-0022 2.48 µM 0.305458861227314 0.372888644505142 no 1257 0.380008348805546 1811 3258434 SGTC_380 3970-0968 6 µM 0.303005744513683 0.373838039678759 no 1258 0.380942741894016 1766 2891601 SGTC_1112 tnp00069 1.16933 µM 0.302887252491344 0.373883917413629 no 1259 0.380987893182264 1878 145826 SGTC_853 0419-0306 21 µM 0.302819123945966 0.373910296229211 no 1260 0.38101385424254 1734 762713 SGTC_3182 9108849 49.47 µM 0.301045828299957 0.374597109196191 no 1261 0.381689774278359 1804 17133045 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.300187983103567 0.374929503157597 no 1262 0.382016885367821 1755 6708784 An antioxidant flavonoid SGTC_208 k072-0098 12.366 µM 0.300123042362036 0.374954669887797 no 1263 0.382041651819588 1794 5948901 SGTC_1498 4478-3555 97.6 µM 0.298503345559419 0.37558252908205 no 1264 0.382659511529499 1904 3437919 SGTC_1076 itraconazole 331 nM 0.29737860401129 0.376018717885939 no 1265 0.383088738376381 1831 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_907 3448-6986 75.5 µM 0.294433291719237 0.377161696156156 no 1266 0.384213415310706 1882 590582 SGTC_1126 isoteolin 1.0172 µM 0.294137032717576 0.377276724256523 no 1267 0.384326596916825 1702 133323 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.293779467699891 0.377415570066589 no 1268 0.384463212763563 1807 88881 An O-methylated flavonoid and antioxidant. SGTC_2799 7812892 81.82 µM 0.293710239972633 0.377442453666109 no 1269 0.384489664449911 1888 20205235 SGTC_816 0325-0417 81.3 µM 0.293589850279538 0.377489206698906 no 1270 0.384535666235617 1761 68101 SGTC_210 3551-0445 56.827 µM 0.293032015563023 0.377705863822207 no 1271 0.384748840188967 1839 2865180 YOR207C RET1 SGTC_58 0957-0393 9 µM 0.292766194464934 0.377809119476331 no 1272 0.384850434754024 1771 6997992 SGTC_2192 5915882 198.485 µM 0.289850039300288 0.378942443758715 no 1273 0.385965482200892 1814 2876149 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.289037210108245 0.379258524873053 no 1274 0.386276451324802 1926 1273210 SGTC_2241 6772625 37.8075 µM 0.286624955837114 0.380197041565554 no 1275 0.387199751916622 1756 2285411 SGTC_2518 prenyletin 46.28 µM 0.286352784070254 0.380302977694717 no 1276 0.387303967001824 1911 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2324 6149169 200 µM 0.285638545909198 0.380581019914064 no 1277 0.387577488754375 1884 2888231 SGTC_2598 perillyl alcohol 100 µM 0.284713035202929 0.380941399125917 no 1278 0.387932001577692 1858 10819 An apoptosis inducer. SGTC_3270 9137563 49.47 µM 0.284131398044466 0.381167932304523 no 1279 0.388154842969172 1872 17015724 SGTC_2083 5306046 65.942 µM 0.283597248101987 0.381376006273653 no 1280 0.388359523129984 1779 539837 SGTC_2979 9012552 45.46 µM 0.282981015483221 0.381616097511746 no 1281 0.388595694953595 1934 17100905 SGTC_4 0960-0234 25.671 µM 0.282709313360375 0.381721970225538 no 1282 0.388699838177019 1790 6821112 SGTC_640 3381-0960 37.1 µM 0.282561589447631 0.381779536726749 no 1283 0.388756464001494 1878 1745025 SGTC_563 tetrahydrosecaminediol 614 µM 0.280586487575305 0.38254946446411 no 1284 0.389513790604674 1934 334274 A psychoactive constituent of the cannabis plant. SGTC_2427 5545055 42.75 µM 0.280401465869151 0.382621612859054 no 1285 0.3895847562704 1828 5372858 SGTC_1970 st070122 35.8 µM 0.280366581018763 0.382635216508526 no 1286 0.389598136878674 1888 102928 SGTC_1864 st057645 30.4 µM 0.279092690205817 0.383132080330608 no 1287 0.390086846356618 1925 688666 SGTC_2505 galangin 7.89 µM 0.279027166082194 0.38315764233329 no 1288 0.390111988428645 1753 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2759 disulfiram 3.38 µM 0.278623244886824 0.383315229646106 no 1289 0.390266986009729 1777 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1365 1672-3266 55.4 µM 0.278308600029705 0.383437999737397 no 1290 0.390387737470879 1918 6415873 SGTC_2797 7859098 81.82 µM 0.277964821702826 0.383572150687983 no 1291 0.390519681590709 1791 972681 SGTC_136 0097-0015 404.482 µM 0.277863415688713 0.383611724531997 no 1292 0.390558604217142 1944 4861337 SGTC_2389 9091542 195.52 µM 0.2763663345892 0.384196103663594 no 1293 0.391133355623884 1792 3626624 YOL127W RPL25 SGTC_3137 9097352 49.47 µM 0.274683600097412 0.384853266113088 no 1294 0.391779665954775 1903 44120435 SGTC_1045 1348-1485 165 µM 0.273430689186144 0.385342783548603 no 1295 0.392261082358139 1861 6810614 SGTC_425 3825-7017 13.1 µM 0.272015891775413 0.385895770353465 no 1296 0.392804900025407 1873 3397440 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.271456478220188 0.386114486425793 no 1297 0.3930199843567 1922 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1875 nocodazole 6 µM 0.270964794588966 0.38630675176198 no 1298 0.393209054738555 1964 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1522 st012842 45.6 µM 0.269044718301995 0.387057835112578 no 1299 0.39394763533929 1728 3491067 YOR116C RPO31 SGTC_1632 st005650 90 µM 0.267872624279231 0.387516535625255 no 1300 0.394398683254362 1838 2759605 SGTC_2358 9037157 4 µM 0.265704057098976 0.388365620881675 no 1301 0.395233569279159 1862 2388925 SGTC_1789 tunicamycin 25 nM 0.265648149326088 0.388387518201383 no 1302 0.395255099832052 1964 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2741 miltefosine 3.04 µM 0.263173206021811 0.389357230307972 no 1303 0.396208540782213 1866 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1642 st009582 77.7 µM 0.262927271246699 0.389453628221548 no 1304 0.396303318099299 1966 6739311 SGTC_1417 3966-0327 90.4 µM 0.260772334454288 0.390298579130904 no 1305 0.397134040179217 1869 651118 SGTC_544 k015-0020 52.4 µM 0.260040617008444 0.390585603718386 no 1306 0.397416221576296 1832 3008304 SGTC_2106 5357045 167.29 µM 0.25959598269857 0.390760045780626 no 1307 0.397587717732475 1920 668842 SGTC_1209 2323-2347 50.3 µM 0.257899272709186 0.391425912730857 no 1308 0.398242323087096 2002 5412760 SGTC_2274 7947094 46.08 µM 0.257068674945315 0.391751993620683 no 1309 0.3985628794373 1945 2971028 SGTC_1298 1079-1278 263 µM 0.25646021035307 0.391990916464126 no 1310 0.398797750380408 1849 2840950 SGTC_1317 1273-0028 910 nM 0.2548707360293 0.392615239618243 no 1311 0.399411469631553 1855 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1310 1188-0297 994 nM 0.253539728428315 0.393138253413248 no 1312 0.399925582472776 1905 1588352 SGTC_1093 fluphenazine 7.97 µM 0.253512543331863 0.393148937695435 no 1313 0.399936084755277 1877 6602611 An atypical antipsychotic. SGTC_2649 anisomycin 9.56 µM 0.252675885739417 0.39347780004426 no 1314 0.400259341860017 1877 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3005 9076496 71.4286 µM 0.25183446094351 0.393808612883204 no 1315 0.400584509785758 1963 21368410 SGTC_1383 3049-0032 20.7 µM 0.25158828230713 0.393905414472573 no 1316 0.400679658358513 1972 712864 SGTC_967 1306-0166 352 µM 0.250591693814825 0.394297356794241 no 1317 0.401064902118127 1988 4437607 SGTC_1845 st056753 3.01 µM 0.249729005695848 0.394636724701624 no 1318 0.401398462722637 1773 5375839 SGTC_2228 7354201 200 µM 0.248993537663646 0.394926109397594 no 1319 0.401682890111927 1949 753451 SGTC_3042 9091578 49.47 µM 0.248211653088221 0.3952338211934 no 1320 0.401985325283477 1961 25236497 SGTC_2086 5274770 176.623 µM 0.247950665752664 0.395336547688212 no 1321 0.402086289000679 1860 689278 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.247562119263161 0.395489495857387 no 1322 0.402236611453548 1905 676296 Flavone; oxidizing agent. SGTC_2118 5526350 200 µM 0.245858913537541 0.396160138611146 no 1323 0.402895724979097 1909 743594 SGTC_1319 1306-0155 43.7 µM 0.245046556995951 0.396480115029428 no 1324 0.403210191384935 1902 3122360 SGTC_1603 st002045 67.8 µM 0.244711466932588 0.396612122868035 no 1325 0.403339924313118 1988 5887985 SGTC_726 3448-4391 34.2 µM 0.243458784169264 0.397105718754719 no 1326 0.403825005063245 1947 1356692 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.242636146686579 0.397429953185667 no 1327 0.404143638399608 1845 442882 SGTC_1282 0886-0010 32.4 µM 0.240686165453117 0.39819880178466 no 1328 0.404899181091377 2007 2836211 YNL267W PIK1 SGTC_1109 tnp00067 928.257 nM 0.240508607027745 0.398268830117426 no 1329 0.404967995807982 1862 676295 SGTC_340 k038-0059 454 µM 0.239888231780079 0.398513529343532 no 1330 0.405208452102263 1893 23733424 SGTC_2212 7123476 200 µM 0.238487686034177 0.399066103628977 no 1331 0.40575143249386 1954 1085715 SGTC_3241 9133421 49.47 µM 0.237943346032229 0.39928092334763 no 1332 0.405962517767924 1961 17018221 SGTC_2683 piperine 63.03 µM 0.237854725596996 0.399315899629759 no 1333 0.405996885770294 1901 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2636 apigenin dimethyl ether 100 µM 0.236477893937509 0.399859404501031 no 1334 0.406530929487277 1916 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2343 7990716 14.84 µM 0.233785536170751 0.400922773736671 no 1335 0.407575739458003 1929 6456862 SGTC_3295 9122362 53.5725 µM 0.232404184428294 0.401468635771005 no 1336 0.408112049594663 1844 4730473 SGTC_3259 9138485 49.47 µM 0.232055957651158 0.401606273245445 no 1337 0.408247275937087 1984 17646153 SGTC_2158 5657123 3.6195 µM 0.23193718380711 0.401653221686823 no 1338 0.408293401692353 1999 2858827 SGTC_1906 st060206 94.7 µM 0.231840686729993 0.401691365703638 no 1339 0.408330877213343 2002 5133468 SGTC_2728 chlorpromazine 9.18 µM 0.231760504079322 0.401723061556202 no 1340 0.408362017515645 1937 2726 A thorazine and dopamine antagonist. SGTC_2597 laccaic acid a 100 µM 0.229720299125437 0.402529762640952 no 1341 0.409154560137251 1883 5491415 A textile dye. SGTC_1086 cerivastatin 2.18 µM 0.228890624611589 0.40285793654712 no 1342 0.409476963813746 2005 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2822 7994718 71.43 µM 0.228223736870337 0.403121770534116 no 1343 0.409736154487924 1953 1018011 SGTC_1752 st044819 83.042 µM 0.227540280882082 0.40339220501431 no 1344 0.410001825462571 1854 441209 YML126C ERG13 SGTC_2843 9000894 45.46 µM 0.227134949771198 0.403552611000045 no 1345 0.410159404089998 1921 2242070 SGTC_963 1269-2853 151 µM 0.226500375484596 0.403803770398362 no 1346 0.410406133612026 1840 3668223 SGTC_2726 cimetidine 79.27 µM 0.226248685000118 0.403903398460476 no 1347 0.410504003492556 2011 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2646 retinol 96.75 µM 0.22542031189446 0.404231342044883 no 1348 0.410826155817625 1938 445354 A vitamin A analog and teratogen. SGTC_800 3448-7362 155 µM 0.225055372500967 0.404375838813342 no 1349 0.410968098980115 2020 15991913 SGTC_799 1310-0557 151 µM 0.224972618783873 0.404408606739528 no 1350 0.411000287657291 1918 5354492 SGTC_2424 5537928 59.2 µM 0.224729382185897 0.404504924830826 no 1351 0.411094902759121 1859 5382802 SGTC_2755 lomerizine 42.69 µM 0.221222418193069 0.405894271135661 no 1352 0.412459627233059 1863 3949 A calcium channel blocker. SGTC_2108 5365811 200 µM 0.21886826771084 0.406827576295875 no 1353 0.413376332932724 1964 780283 SGTC_2934 9036370 36.88 µM 0.21778487784817 0.407257265425006 no 1354 0.413798363750912 2001 6462800 SGTC_3272 9137413 49.47 µM 0.217564616140106 0.407344638287161 no 1355 0.413884178143534 1977 17614870 SGTC_970 1315-0089 19.5 µM 0.217346166576538 0.407431296865826 no 1356 0.413969290582935 1950 6811083 YLR033W RSC58 SGTC_2303 7774051 200 µM 0.217316181354605 0.407443192307224 no 1357 0.413980973757147 2001 2953184 SGTC_2640 pentamidine 10.38 µM 0.21731588330321 0.407443310547661 no 1358 0.413981089887614 2051 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_699 0375-0592 111 µM 0.215926516494266 0.407994579903189 no 1359 0.414522513726003 2084 762578 SGTC_448 monastrol 171 µM 0.215428102695863 0.408192383693423 no 1360 0.414716780775924 1997 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_46 0329-0187a 2.197 µM 0.21480682760116 0.408438979783368 no 1361 0.414958964749817 1959 46494817 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.212904592479402 0.409194238738259 no 1362 0.415700690113019 1992 616764 SGTC_2445 5742597 35.57 µM 0.212823682361392 0.409226370597236 no 1363 0.41573224551457 1895 1774255 SGTC_785 1270-0111 65.3 µM 0.210938127916237 0.409975353673466 no 1364 0.416467775831239 2044 6741994 SGTC_905 2-aminofluorene 215 µM 0.209549305075531 0.41052723449302 no 1365 0.417009724868567 1982 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2655 perillic acid 100 µM 0.209148640517984 0.410686480788848 no 1366 0.417166102301436 1925 5702197 An apoptosis inducer. SGTC_3151 9099821 49.47 µM 0.207833635065326 0.411209240148804 no 1367 0.417679434507993 1891 17174189 SGTC_224 benfluorex 43.875 µM 0.207164497495471 0.411475305672969 no 1368 0.417940696365996 2033 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1278 0874-0585 172 µM 0.205905929581579 0.411975853390793 no 1369 0.418432196780864 1981 766306 SGTC_1347 1493-0251 600 nM 0.205565682450442 0.412111198432126 no 1370 0.418565093205288 2028 3986378 SGTC_146 3448-8650 53.125 µM 0.204674622884937 0.41246569763308 no 1371 0.418913174331619 1950 2891488 YIL048W NEO1 SGTC_309 k408-0051 1.48 µM 0.204540057124882 0.412519239498945 no 1372 0.418965746264724 1958 3640463 SGTC_1690 st023502 41.2 µM 0.204539147815678 0.412519601306115 no 1373 0.418966101517094 2045 24207482 SGTC_3355 9151058 44.0485 µM 0.203048327955918 0.41311288685829 no 1374 0.419548629325059 2061 17015728 SGTC_396 dithiazanine 1.25 µM 0.201813156904784 0.413604585016213 no 1375 0.420031397729865 1890 10578 An antihelmenthic. SGTC_2907 7721985 69.9 µM 0.201437231438033 0.413754260743082 no 1376 0.420178352668326 1889 3267881 SGTC_2864 9034755 47.6 µM 0.199311753281782 0.414600760645116 no 1377 0.421009442914358 2095 4930451 SGTC_2512 diallyl trisulfide 49.23 µM 0.197652376831386 0.415261905353926 no 1378 0.421658526156086 2069 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2821 7996764 71.43 µM 0.197031716549211 0.415509256563353 no 1379 0.421901359017186 1974 2987135 SGTC_1059 3448-6867 171 µM 0.195721337100921 0.416031590821049 no 1380 0.422414141403677 2105 3934407 SGTC_863 0466-0191 129 µM 0.195347794533136 0.416180516951114 no 1381 0.422560341549691 2076 765160 YPR165W RHO1 SGTC_364 0083-0097 67.7 µM 0.195126525608967 0.416268739414106 no 1382 0.422646948624172 1946 5207356 SGTC_2112 5488546 200 µM 0.194834577925398 0.416385148765348 no 1383 0.422761225858468 1972 600757 SGTC_2580 diallyl disulphide 81.36 µM 0.194590153813931 0.416482614512685 no 1384 0.422856905915845 1923 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.19252931646342 0.417304590773926 no 1385 0.42366380311276 1940 688803 SGTC_1189 1431-2119 7.28 µM 0.192436971688363 0.41734143148277 no 1386 0.423699967169343 2006 3107275 SGTC_2647 atorvastatin 60.16 µM 0.19168407828454 0.417641823404818 no 1387 0.423994839202763 2034 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2871 9038510 12.99 µM 0.191265171085282 0.417808981219728 no 1388 0.424158923385863 2093 4945164 SGTC_3336 9143619 71.43 µM 0.191200329892018 0.417834856326463 no 1389 0.424184322583491 2062 45595730 SGTC_2335 9018011 154.17 µM 0.190785615346375 0.418000358035995 no 1390 0.424346779484793 2057 6458208 SGTC_3338 9144300 39.5675 µM 0.190499530237295 0.418114535573595 no 1391 0.424458855631206 2016 4901274 SGTC_73 0327-0325 16.231 µM 0.188490133703834 0.418916686490166 no 1392 0.425246224532894 2103 53298 SGTC_1985 st071382 65.5 µM 0.188467613817803 0.418925678343605 no 1393 0.425255050498962 2036 6123237 SGTC_1217 1183-1422 255 µM 0.186352759135036 0.419770296282038 no 1394 0.426084068093892 2041 2849664 SGTC_530 4358-1714 28 µM 0.186207601939337 0.419828281892147 no 1395 0.426140981366537 2014 1564641 SGTC_1477 0139-0234 16 µM 0.186001549183155 0.419910596300109 no 1396 0.426221773228529 2061 620880 SGTC_1443 4112-3303 14 µM 0.18562936863295 0.420059284682054 no 1397 0.426367710496127 1973 704433 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.185190827911853 0.420234498996105 no 1398 0.426539681465322 1926 2374 Ca(2+)-ATPase inhibitor. SGTC_2952 9073731 13.78 µM 0.184062241483277 0.420685486396025 no 1399 0.426982313638959 1938 16457353 SGTC_697 0508-1955 564 µM 0.182737672579374 0.421214921907115 no 1400 0.427501927496444 2094 6243113 SGTC_672 1441-0018 53.7 µM 0.181120117852229 0.421861658194995 no 1401 0.428136646990805 1958 251141 SGTC_2062 5245942 200 µM 0.179526435575092 0.422499055889006 no 1402 0.428762180961174 2097 1376160 SGTC_289 k017-0060 526 µM 0.179254859327969 0.422607693859468 no 1403 0.428868794861269 2012 5512909 SGTC_2556 citropten 84.59 µM 0.176809219630154 0.423586281268349 no 1404 0.42982912346815 2008 2775 A potential DNA crosslinker. SGTC_1197 1601-0112 267 µM 0.17642642851258 0.423739492433806 no 1405 0.429979471675844 1938 7350313 SGTC_2545 solidagenone 89.61 µM 0.175595891836755 0.4240719522274 no 1406 0.430305715022131 2041 6708572 An anti ulcer agent SGTC_1089 terbinafine 2.25 µM 0.172652503566861 0.425250609810791 no 1407 0.431462289834458 2101 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_298 1391-0729 10 µM 0.172295148711806 0.425393755573054 no 1408 0.431602749045131 1979 3237558 SGTC_2675 theaflavin digallate 100 µM 0.17102660318729 0.425901976605684 no 1409 0.432101423725708 2054 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1476 4112-3294 3.34 µM 0.170786747827971 0.425998084410918 no 1410 0.432195724838561 2073 704369 SGTC_2418 pentamidine 31.67 µM 0.170495040148104 0.426114974880683 no 1411 0.432310417324392 2131 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.169880659628127 0.426361185122221 no 1412 0.43255199570431 2046 6312947 SGTC_1903 st060211 78.3 µM 0.169605179088354 0.426471592040555 no 1413 0.43266032462107 2105 688960 SGTC_1764 st044502 93.5 µM 0.169391052174798 0.426557413671559 no 1414 0.432744530568437 2001 8407 SGTC_2388 9080168 200 µM 0.168704134247218 0.426832752429971 no 1415 0.433014683368059 1920 15943073 SGTC_2134 5324836 1.464 µM 0.168569410762478 0.426886758114304 no 1416 0.433067671433203 2038 699272 SGTC_2936 9038235 15.59 µM 0.168521821492672 0.426905835227891 no 1417 0.433086389046459 2070 4749415 SGTC_2491 paeonol 100 µM 0.168024879665521 0.427105054535267 no 1418 0.433281853095043 1982 11092 Increases levels of cortical cytochrome oxidase. SGTC_363 0455-0021 3.06 µM 0.1679920915564 0.427118199634411 no 1419 0.433294750343155 2023 4597466 SGTC_299 1273-0059 1.44 µM 0.167272690495172 0.427406635457885 no 1420 0.433577745601629 2102 2848077 SGTC_2349 9023730 187.07 µM 0.164837297682963 0.428383366189982 no 1421 0.434536023135782 2074 4126287 SGTC_3173 9105693 49.47 µM 0.164558781473772 0.42849509507333 no 1422 0.434645638220679 2071 17096658 SGTC_1124 fisetin 1.16336 µM 0.164457712610034 0.428535641030022 no 1423 0.43468541694038 1940 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2516 gossypol 71.55 µM 0.164218647659447 0.42863155009777 no 1424 0.434779510840446 2098 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1200 1643-0193 18.4 µM 0.164131121211824 0.428666665375164 no 1425 0.434813961418485 2122 5403974 SGTC_2909 7941780 10.49 µM 0.162991115353126 0.429124082860619 no 1426 0.435262715024281 2134 1243215 SGTC_3155 9099265 49.47 µM 0.159352264678677 0.430584774161097 no 1427 0.436695672761068 2057 25236499 SGTC_618 k072-0232 33.2 µM 0.158938072526442 0.430751097948347 no 1428 0.436858832198985 2034 5872756 YGL099W LSG1 SGTC_1229 0139-0193 12.2 µM 0.158264076342749 0.431021775381414 no 1429 0.437124357132192 2145 3090752 SGTC_1386 3228-0095 33.8 µM 0.157459546186834 0.431344917780898 no 1430 0.437441343799665 2099 870181 SGTC_718 1130-0073 349 µM 0.15701910193241 0.43152184326307 no 1431 0.43761489683695 2075 6740020 SGTC_533 1222-0222 6.71 µM 0.156894493078018 0.431571900858946 no 1432 0.43766399999809 2123 3982874 SGTC_3165 9101544 49.47 µM 0.156221417341419 0.431842306347613 no 1433 0.437929247699268 2084 5002184 SGTC_431 k089-0097 107 µM 0.156193862204215 0.431853377195286 no 1434 0.437940107305334 2126 5499420 SGTC_2097 5376186 200 µM 0.155021451860047 0.432324466831802 no 1435 0.43840220280147 2112 742755 SGTC_1853 st056710 91.2 µM 0.15319393247818 0.433058979417713 no 1436 0.439122671188316 2170 269167 SGTC_2280 7785178 200 µM 0.151976823551501 0.433548285658994 no 1437 0.439602607711099 2033 2954328 SGTC_867 0518-0118 155 µM 0.151706052094547 0.43365715599293 no 1438 0.439709391773346 2177 6848158 SGTC_2551 apiole 73.87 µM 0.151197489208829 0.433861649827473 no 1439 0.439909965423904 2137 10659 A possible DNA adduct former. SGTC_1820 st053765 18.6 µM 0.15075058731964 0.434041364306362 no 1440 0.440086233141464 2002 3690829 SGTC_2208 7283366 200 µM 0.150553179615572 0.434120753014954 no 1441 0.440164098769541 2133 898663 SGTC_341 1486-1430 230 µM 0.149183345772125 0.434671713046554 no 1442 0.44070448053973 2058 2054753 YPL210C SRP72 SGTC_3013 9080133 71.4286 µM 0.149107724612786 0.434702132292416 no 1443 0.440734315336845 2089 17050193 SGTC_557 1315-0110 16.2 µM 0.148286455109303 0.435032519698868 no 1444 0.441058352219638 2114 6833801 SGTC_2174 5790901 200 µM 0.147073892769042 0.43552040264587 no 1445 0.441536848159692 2036 786020 SGTC_1608 st001473 40.5 µM 0.146957260044402 0.435567335825885 no 1446 0.441582877755107 1970 7292267 SGTC_1063 disulfiram 1.84 µM 0.146303315724748 0.435830500773432 no 1447 0.441840974227333 2146 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_589 1227-0070 34.1 µM 0.146285387160062 0.435837716115318 no 1448 0.441848050559243 2067 2841384 SGTC_1591 genipin 88.4 µM 0.145733388013635 0.436059878335222 no 1449 0.442065931459344 2136 442424 A DNA cross-linking agent. SGTC_857 0438-0306 1.35 µM 0.145248501055103 0.436255046667226 no 1450 0.442257336810828 2072 4686136 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.14222582567359 0.437472029928121 no 1451 0.44345081660295 2010 23665772 A membrane-active detergent. SGTC_1438 4092-1045 4 µM 0.14146906651429 0.437776807801358 no 1452 0.44374969779569 2120 1351342 SGTC_1065 prochlorperazine maleate 2.48 µM 0.140624528503121 0.438116981392117 no 1453 0.444083284923362 2159 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3226 9131256 49.47 µM 0.138881503215823 0.438819203252844 no 1454 0.444771893801115 2148 17178073 SGTC_2571 chrysanthemic acid 100 µM 0.138406501721058 0.439010603121019 no 1455 0.444959579421063 1986 2743 An insecticide. SGTC_2224 6650123 117.647 µM 0.138370894183054 0.439024951604883 no 1456 0.444973649396256 2075 2908370 SGTC_1774 st048371 48.465 µM 0.137968686287423 0.439187031652752 no 1457 0.445132582776616 2083 4242727 SGTC_2561 acetosyringone 100 µM 0.137790688751813 0.43925876360802 no 1458 0.445202921731346 2198 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_226 1,3-diallylurea 8.28947 mM 0.137360802010271 0.439432013646468 no 1459 0.445372806384961 2116 74537 YKL182W FAS1 SGTC_2433 5607874 27.82 µM 0.136053828464766 0.439958812377441 no 1460 0.445889363789982 2109 2252428 SGTC_1754 st042065 16.137 µM 0.135846844406286 0.440042250727334 no 1461 0.445971178904138 2093 1126236 YIL048W NEO1 SGTC_1238 0333-0287 48.8 µM 0.135746814098398 0.440082575385615 no 1462 0.446010718962585 2085 7226 SGTC_2278 7948257 134.34 µM 0.135290215646946 0.440266649251588 no 1463 0.446191210369036 2204 1247028 SGTC_3149 9097855 49.47 µM 0.135113233184258 0.440338001732777 no 1464 0.446261173776802 2152 25236625 YMR079W SEC14 SGTC_2249 haloperidol 116.36 µM 0.134193992991946 0.44070863492492 no 1465 0.446624587924022 2065 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1609 st001574 46.4 µM 0.133785034151591 0.44087354186325 no 1466 0.446786280908762 2119 3960012 SGTC_1941 st076221 61.8 µM 0.132928676226288 0.441218889413324 no 1467 0.447124893900231 2196 2828568 SGTC_1815 st051655 58.2 µM 0.132292869494116 0.441475323159468 no 1468 0.447376323562776 2182 5984156 SGTC_1379 2144-0755 36.5 µM 0.130669287303856 0.44213025784524 no 1469 0.448018464583159 2175 5392327 SGTC_643 k048-0106 28.4 µM 0.13057960179113 0.442166440593962 no 1470 0.448053939977594 2117 6763920 SGTC_262 fenpropimorph 62.5 µM 0.129290697331339 0.442686489722359 no 1471 0.448563816053491 2163 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_700 3453-2283 142 µM 0.129178421442161 0.44273179565795 no 1472 0.448608235165133 2152 565664 SGTC_2827 7993847 71.43 µM 0.127520472438931 0.443400903552642 no 1473 0.449264235396149 2087 2985692 SGTC_1838 st055369 84.5 µM 0.127246673141407 0.443511417870114 no 1474 0.449372582881984 2184 676036 SGTC_504 lovastatin 124 µM 0.126275724188382 0.443903359862908 no 1475 0.449756835856222 2011 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3123 9126162 49.47 µM 0.125817398594646 0.44408839078561 no 1476 0.449938234566034 2141 25239884 SGTC_2686 alizarin 95.37 µM 0.125130501965885 0.444365721077187 no 1477 0.450210117995052 2070 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_275 trichlorophene 5.69 µM 0.122940706992023 0.445250018533114 no 1478 0.451077025297669 2103 62616 SGTC_273 hydroxyurea 18.1 mM 0.122582561107425 0.44539467341222 no 1479 0.451218832251755 2170 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1370 2001-0092 44.6 µM 0.121396661240625 0.445873709351035 no 1480 0.451688430633793 2165 790957 SGTC_2507 purpurin 79.67 µM 0.121061288801689 0.446009195060883 no 1481 0.45182124533095 2116 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2781 5567276 71.43 µM 0.121016504465543 0.446027287775138 no 1482 0.451838981299483 2142 2853274 SGTC_3230 9131665 49.47 µM 0.120766707990391 0.446128206732885 no 1483 0.451937910115455 2130 15943720 SGTC_3274 9138298 49.47 µM 0.120378895470166 0.446284891738335 no 1484 0.452091504396603 2206 17015756 SGTC_394 menadione 8.33 µM 0.119229358806774 0.446749379663935 no 1485 0.4525468237903 2200 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3008 9078912 71.4286 µM 0.113993828587892 0.448865790720134 no 1486 0.454621342813916 2114 16648731 SGTC_1196 1588-0294 184 µM 0.1131147637656 0.449221288320271 no 1487 0.454969785161516 2080 6144269 SGTC_495 decylubiquinone 155 µM 0.113048750146432 0.449247986161305 no 1488 0.454995952939253 2071 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1041 0206-0046 107 µM 0.112685187658029 0.449395025593996 no 1489 0.455140072490884 2099 50494 SGTC_441 propafenone 146 µM 0.109423743858742 0.450714394317771 no 1490 0.456433200973151 2195 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_829 1635-0120 117 µM 0.109279458758607 0.450772775406065 no 1491 0.456490419273527 2205 285054 SGTC_2314 7727897 200 µM 0.108819192655998 0.450959016826977 no 1492 0.456672950340133 2133 900724 SGTC_554 4483-2211 187 µM 0.108290496477935 0.451172961018278 no 1493 0.456882630498109 2116 747107 SGTC_801 0866-0028 10.1 µM 0.106636739653889 0.451842267796285 no 1494 0.4575385853619 2180 6849771 SGTC_3297 9117502 71.43 µM 0.106603492647804 0.451855724900892 no 1495 0.457551773822663 2260 7453720 SGTC_2214 7179297 48.276 µM 0.105895926294356 0.452142133537733 no 1496 0.457832463120712 2208 769744 SGTC_1434 4073-0095 163 µM 0.105538737053419 0.452286726032208 no 1497 0.457974166941806 2208 24133745 SGTC_758 0868-0029 16 µM 0.103868393849634 0.452962975351554 no 1498 0.458636894729373 2250 762687 SGTC_1284 0929-0043 16 µM 0.103642042270448 0.453054625802862 no 1499 0.45872671119727 2116 1239883 SGTC_543 3844-1095 191 µM 0.101559092560911 0.453898135325591 no 1500 0.459553325452366 2170 4230703 SGTC_671 0560-0003 407 µM 0.10151078176457 0.453917701706789 no 1501 0.459572499580117 2184 3238678 SGTC_284 0988-0104 32.6 µM 0.100832301762648 0.454192505045202 no 1502 0.459841792204751 2206 4666532 SGTC_1722 st034304 3.6505 µM 0.100615322055082 0.45428039251727 no 1503 0.459927916595679 2149 4036148 YLR033W RSC58 SGTC_2762 leflunomide 42.06 µM 0.0993647844997531 0.454786965337888 no 1504 0.460424321125695 2141 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_525 k781-2675 26.7 µM 0.0991553530124375 0.454871809904935 no 1505 0.460507461616796 2251 3651118 YDL195W SEC31 SGTC_1821 st053465 65.6 µM 0.0990229294790866 0.454925458188939 no 1506 0.460560032242085 2139 675086 SGTC_2528 xanthyletin 44.79 µM 0.098567065990701 0.455110146853746 no 1507 0.46074101008873 2137 65188 An natural product with antifungal activity of unknown mechanism. SGTC_451 chloral hydrate 100 µM 0.0982324065883527 0.455245737038826 no 1508 0.460873875080521 2127 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_304 1310-0298 97 µM 0.0971135129715286 0.455699104344529 no 1509 0.461318124893264 2168 1550234 SGTC_787 4152-0075 138 µM 0.0961923533297682 0.456072394653071 no 1510 0.461683901906218 2097 9566539 SGTC_1779 st039427 55 µM 0.0957603175142672 0.456247486026273 no 1511 0.461855467252458 2257 1124498 SGTC_20 0481-0013 4.944 µM 0.0950015740915105 0.456555002898909 no 1512 0.462156788316562 2178 182045 SGTC_2830 7992007 71.43 µM 0.0944590876794603 0.456774887293009 no 1513 0.46237224019335 2174 1952075 SGTC_2384 9036245 200 µM 0.0940168683300387 0.456954140533865 no 1514 0.462547878549264 2190 6462766 SGTC_2737 bleomycin 30.5 nM 0.0932248315204394 0.457275213856222 no 1515 0.462862473794433 2213 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3068 9116768 49.47 µM 0.0930530076903195 0.457344870933805 no 1516 0.462930724907652 2154 41904888 SGTC_2777 climbazole 1.536 µM 0.0926801511065104 0.457496030839318 no 1517 0.463078833126081 2258 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1388 3346-4487 254 µM 0.0919344219943363 0.457798375540134 no 1518 0.463375071231186 2186 3345614 SGTC_2355 9061122 103.12 µM 0.0903460273529852 0.458442447554656 no 1519 0.464006122568508 2231 5302957 SGTC_2841 9004761 38.96 µM 0.0887453249306364 0.459091620596217 no 1520 0.464642155265695 2101 2991039 SGTC_1900 st060200 72.8 µM 0.088257527336743 0.459289471170839 no 1521 0.464835997724075 2216 688945 SGTC_1401 3807-4679 7.6 µM 0.0878986847372222 0.459435024073978 no 1522 0.464978600993646 2237 3291456 SGTC_3193 9111931 49.47 µM 0.0876724612583774 0.459526787112585 no 1523 0.465068504025568 2195 17087244 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.0871921991949836 0.459721602973777 no 1524 0.465259369941633 2177 2724 A muscle relaxant with antifungal properties. SGTC_1743 st037606 46.3785 µM 0.0857372983417918 0.460311834933283 no 1525 0.465837625745502 2197 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1951 sophoraflavanone G 9.2 µM 0.0855951161443462 0.460369520879821 no 1526 0.465894140482286 2194 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2865 9030313 51.95 µM 0.0826734095413937 0.461555094208418 no 1527 0.467055614292999 2234 42562754 SGTC_1281 0884-0031 11.8 µM 0.0816588386232077 0.461966868387758 no 1528 0.467459005508694 2225 1548255 SGTC_2596 sinensetin 100 µM 0.0812057265072557 0.462150781857742 no 1529 0.467639172732619 2190 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2185 6113692 200 µM 0.0811798949114893 0.462161266876563 no 1530 0.467649444136535 2190 874150 SGTC_1862 st057513 3.81 µM 0.0801970367357049 0.462560227491852 no 1531 0.468040273457481 2242 5393163 SGTC_2173 5763948 167 µM 0.080109719712363 0.462595672941257 no 1532 0.468074996191326 2268 2867177 SGTC_1739 st037196 92.5 µM 0.0795536180461358 0.462821423662547 no 1533 0.468296142837051 2257 612214 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.0787933466555424 0.463130076904932 no 1534 0.468598498097507 2223 7104 SGTC_1015 4130-4525 82 µM 0.0780846669860366 0.463417805051179 no 1535 0.468880351961966 2091 1363237 SGTC_1363 1636-0063 10.4 µM 0.0778572155833485 0.463510155732746 no 1536 0.468970816536443 2246 6072185 SGTC_3044 9093193 49.47 µM 0.0774762507625667 0.463664840917354 no 1537 0.469122341810579 2165 25236277 SGTC_1976 st070609 63.5 µM 0.0767912703804437 0.463942980969337 no 1538 0.469394797730012 2260 682556 SGTC_1178 0988-0033 191 µM 0.0761506171222635 0.464203137701278 no 1539 0.469649635187132 2219 5392207 SGTC_306 1672-3436 11.6 µM 0.0758029587092155 0.464344321382705 no 1540 0.469787931095308 2208 6797378 SGTC_481 bay k-8644 50 µM 0.0755738027339396 0.464437383816578 no 1541 0.469879089616814 2142 2303 A calcium channel antagonist. SGTC_1686 st019653 115.5 µM 0.0744938126158996 0.464876004242383 no 1542 0.470308732153289 2270 97252 SGTC_1975 st070967 30.8 µM 0.0741181631399083 0.465028578201103 no 1543 0.470458181457777 2291 261391 SGTC_2465 5809242 33.21 µM 0.074100568271914 0.465035724666761 no 1544 0.470465181545187 2279 2731748 SGTC_987 1497-1013 404 µM 0.0730053574262938 0.465480585956184 no 1545 0.47090092713991 2263 1676435 SGTC_326 k292-0812 17.5 µM 0.0728509471162333 0.465543309023901 no 1546 0.470962364346275 2273 3579357 SGTC_2227 7312221 64.1025 µM 0.0722860075459495 0.465772800613923 no 1547 0.471187149962631 2260 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_194 1486-1323 56.904 µM 0.0717394040203214 0.465994854511479 no 1548 0.471404648529868 2189 5178754 SGTC_605 1315-0399 119 µM 0.0717323932511524 0.465997702656823 no 1549 0.4714074382349 2214 24020461 SGTC_3319 9138450 16.7555 µM 0.0714786529929647 0.466100786544908 no 1550 0.471508406769218 2152 2029690 SGTC_2398 5228213 48.84 µM 0.0711917032314818 0.46621736478341 no 1551 0.47162259226282 2289 80771 YMR134W ERG29 SGTC_8 0354-0001 70 µM 0.0702911067331708 0.466583266262079 no 1552 0.471980980399463 2239 4993152 SGTC_2992 9074591 71.4286 µM 0.0699952532744788 0.466703474127101 no 1553 0.472098718855485 2308 17741321 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.0697593333437658 0.466799332649197 no 1554 0.472192607788241 2257 23847180 SGTC_2784 7567673 72.73 µM 0.069450273938852 0.466924911971553 no 1555 0.472315606336905 2281 3471247 SGTC_247 mechlorethamine 29.705 µM 0.0693035486457097 0.466984531640283 no 1556 0.472374000560409 2244 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1270 0831-1170 17.3 µM 0.0690521197509367 0.467086697801848 no 1557 0.472474066453791 2283 6764716 SGTC_2107 5363541 170.161 µM 0.0680958654172055 0.467475284008231 no 1558 0.472854660819019 2286 244052 SGTC_3112 9123419 49.47 µM 0.0672468150751317 0.467820332489901 no 1559 0.473192608202109 2304 17015854 SGTC_2064 5220758 200 µM 0.0657121743296098 0.468444061579524 no 1560 0.473803489825572 2217 788518 SGTC_1137 ixabepilone 100 µM 0.0656491822755712 0.468469665312972 no 1561 0.473828565872452 2303 154225 A novel microtubule stabilizer. SGTC_2396 5342950 42.78 µM 0.0647956229236245 0.468816615631891 no 1562 0.474168363264744 2211 1886677 SGTC_3136 9095672 49.47 µM 0.0646447690286746 0.468877936400383 no 1563 0.474228419351164 2313 17217380 SGTC_2835 9006588 71.43 µM 0.0645420075078405 0.46891970846878 no 1564 0.474269329832003 2148 2345538 SGTC_2940 9060638 45.86 µM 0.0632417587631062 0.469448282784802 no 1565 0.474786996313885 2206 4027022 SGTC_2089 5281248 129.67 µM 0.0629749253389633 0.469556762022626 no 1566 0.474893235679717 2252 2737878 SGTC_2956 9076196 2.52 µM 0.062773411683568 0.469638687469448 no 1567 0.474973469251846 2313 16423868 SGTC_596 1155-0152 116 µM 0.0617177680931176 0.470067880662791 no 1568 0.475393795025456 2289 280313 SGTC_1268 0828-0275 2.46 µM 0.0611285938088181 0.470307436504413 no 1569 0.475628398579933 2257 745337 SGTC_1121 fusaric acid 630.51 nM 0.0606362895099308 0.47050761365328 no 1570 0.475824435917693 2186 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2439 5492030 7.2 µM 0.0604162365938899 0.470597092362788 no 1571 0.475912063673547 2302 5722370 SGTC_824 1304-0008 100 µM 0.0598152683269931 0.470841467794699 no 1572 0.476151382492283 2259 768245 SGTC_2706 st078239 82.5 µM 0.0591558060949695 0.47110964162077 no 1573 0.476414004794595 2311 15434492 SGTC_1248 0469-0687 58.6 µM 0.0586756935487285 0.471304890190666 no 1574 0.476605209856027 2248 4017482 SGTC_2999 9069765 71.4286 µM 0.0586046651450099 0.471333776076046 no 1575 0.476633497411745 2278 2097066 SGTC_1378 2093-0007 380 nM 0.0578508975679778 0.471640328111132 no 1576 0.476933697818203 2243 3618014 SGTC_473 2-arachidonoylglycerol 10 µM 0.0568436787827893 0.472049983186787 no 1577 0.477334859764705 2225 5282280 An endocannabinoid. SGTC_921 1561-0023 372 µM 0.0555024619011024 0.472595527483844 no 1578 0.477869084330993 2334 24050882 SGTC_1162 k048-0130 20.1 µM 0.0552590498310914 0.472694541671118 no 1579 0.477966042895654 2254 6797406 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.0552522629782395 0.472697302424155 no 1580 0.477968746328012 2301 94937 An inhibitor of serotonin biosynthesis. SGTC_727 3032-0951 202 µM 0.0552508676259004 0.472697870025132 no 1581 0.477969302144029 2255 3652836 SGTC_2117 5521686 200 µM 0.053064472498028 0.473587318499237 no 1582 0.478840269195564 2269 803312 SGTC_1526 st051518 75 µM 0.0526093919062044 0.473772466763063 no 1583 0.479021566838295 2146 673993 SGTC_3033 9090887 49.47 µM 0.0513244858589962 0.474295257638854 no 1584 0.479533478460093 2279 19325384 SGTC_537 1334-0398 209 µM 0.0507600615284549 0.47452491951932 no 1585 0.479758358054823 2333 5846986 SGTC_958 1222-0007 33 µM 0.0505973168009589 0.474591141238588 no 1586 0.479823200485609 2297 7312461 SGTC_3059 1327-0034 3 µM 0.0503128796338882 0.474706881961336 no 1587 0.479936530152818 2271 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2807 7945238 51.95 µM 0.0498295061974164 0.474903577008821 no 1588 0.48012912666888 2284 17148797 SGTC_1131 3454-3128 32.3 µM 0.0493849316749197 0.475084489345094 no 1589 0.480306268145468 2241 710982 SGTC_313 3474-0040 5.03 µM 0.0485618445136342 0.475419444745822 no 1590 0.480634238868096 2319 1043375 YIL048W NEO1 SGTC_2040 5100729 123 µM 0.0479303448371825 0.475676445390972 no 1591 0.480885877746321 2283 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_647 0140-0236 81 µM 0.0475814465099693 0.475818440460139 no 1592 0.481024909409893 2263 990837 SGTC_2150 5556613 200 µM 0.0462819965841458 0.476347319059902 no 1593 0.48154274428798 2278 743190 SGTC_2210 7115885 190.385 µM 0.0462546162763422 0.476358463348956 no 1594 0.481553655764754 2312 2927039 SGTC_2570 licareol 100 µM 0.0462362074317674 0.476365956097803 no 1595 0.481560991982235 2228 443158 SGTC_1813 st051246 8.6015 µM 0.0457146170146054 0.476578256751651 no 1596 0.481768856648432 2330 5291959 SGTC_2566 crystal violet carbinol 226 nM 0.0456204334019169 0.476616592603743 no 1597 0.481806391313526 2159 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2073 5212005 126 µM 0.0453844953667053 0.476712628153632 no 1598 0.481900419579154 2324 691789 SGTC_1340 1486-1359 257 µM 0.0453599206144965 0.476722631069069 no 1599 0.481910213400687 2240 4309068 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.0431277582558022 0.477631271575936 no 1600 0.482799845995909 2325 66535 A nucleotide analog. SGTC_1913 st060213 96.1 µM 0.0430289633144797 0.477671490497189 no 1601 0.482839222921351 2323 688959 SGTC_1309 pyrazolanthrone 13.4 µM 0.04127926154757 0.478383822543889 no 1602 0.483536632931978 2338 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1513 0337-0559 19 µM 0.0402146951713359 0.478817258765658 no 1603 0.483960981027449 2268 775073 SGTC_3320 9137005 35.139 µM 0.0378007394542323 0.47980018836076 no 1604 0.484923277397937 2200 4908713 SGTC_18 0111-0177 500 nM 0.0373847364763713 0.479969591632488 no 1605 0.485089121345482 2329 721752 SGTC_2366 9070441 60.58 µM 0.0373143836633136 0.479998240816449 no 1606 0.48511716848759 2340 6837235 SGTC_2235 salicylic acid 500 µM 0.0366285988492556 0.480277512584544 no 1607 0.485390570120815 2342 338 A COX inhibitor and kinase inhibitor. SGTC_669 0108-0021 26.2 µM 0.0364035314353923 0.480369168778847 no 1608 0.48548029918461 2364 17201 SGTC_2196 6573537 42.6665 µM 0.036289997971015 0.4804154044102 no 1609 0.485525562575444 2341 2903087 SGTC_3206 9114350 49.47 µM 0.0361875483511551 0.480457126457174 no 1610 0.485566407231997 2352 17087243 SGTC_3075 9116269 49.47 µM 0.035362083870694 0.480793300121669 no 1611 0.485895509238948 2298 17015205 YNL244C SUI1 SGTC_3034 9090421 49.47 µM 0.0337412157958874 0.481453444558433 no 1612 0.486541756108998 2336 17173761 SGTC_3143 9086658 49.47 µM 0.032548959861584 0.481939057126552 no 1613 0.487017136184854 2278 25236626 SGTC_602 3130-1533 38.1 µM 0.0319395739818298 0.482187273827767 no 1614 0.487260119626711 2342 720941 SGTC_3031 9088762 49.47 µM 0.0315836797305337 0.482332240834794 no 1615 0.487402029292798 2354 205253 SGTC_1568 digitonin 820 nM 0.0314068917653494 0.482404253045118 no 1616 0.48747252251503 2352 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1428 4049-0204 61.7 µM 0.0302419966920464 0.482878771699141 no 1617 0.487937027659388 2347 X1428 SGTC_1279 0874-0590 65.2 µM 0.0280563072736768 0.483769174659744 no 1618 0.488808621043408 2326 3523074 SGTC_1682 st012968 530 nM 0.0271086367293249 0.48415526071913 no 1619 0.489186543089779 2331 24207270 SGTC_3025 9087895 49.47 µM 0.0259870383492591 0.484612225078722 no 1620 0.489633838429882 2357 17173641 SGTC_2857 9024691 58.44 µM 0.0255222305875376 0.484801604153107 no 1621 0.489819208408363 2331 16478292 SGTC_236 1509-0011 5.31 µM 0.0246819506581015 0.485143972501891 no 1622 0.490154325991798 2355 3107280 SGTC_1465 k213-0056 144 µM 0.0245749972372404 0.485187550992163 no 1623 0.490196981294894 2321 24048857 YMR208W ERG12 SGTC_2221 6807166 181.081 µM 0.0244231334261676 0.485249428658662 no 1624 0.490257548011009 2363 674925 SGTC_3333 9141820 12.094 µM 0.0219007596035861 0.486277233250731 no 1625 0.491263559422627 2345 1939433 SGTC_1880 MG-132 525 µM 0.0208841311346024 0.486691510224634 no 1626 0.491669042692274 2364 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1186 1319-0216 26 µM 0.0201359047197827 0.486996422331346 no 1627 0.491967479060651 2369 4565136 SGTC_244 nsc-207895 1.295 µM 0.0186092611696066 0.487618573047039 no 1628 0.492576407385597 2362 42640 SGTC_821 1114-0266 29.2 µM 0.0185139751280043 0.48765740583688 no 1629 0.492614414468387 2361 3123235 SGTC_2955 9076254 12.21 µM 0.018135159696794 0.487811789099306 no 1630 0.492765514588394 2370 16459619 SGTC_2748 diazoxide 86.69 µM 0.0171575501890352 0.488210214580713 no 1631 0.493155463620645 2366 3019 A potassium channel activatior. SGTC_2243 6634756 200 µM 0.0165238255523802 0.488468495838188 no 1632 0.493408247319731 2363 885676 SGTC_2115 tiliquinol 12.7705 µM 0.0164403274052067 0.48850252676454 no 1633 0.493441553736666 2350 71208 A bioactive hydroxyquinoline. SGTC_2817 7995342 71.43 µM 0.0151914619933636 0.489011530507554 no 1634 0.493939716609855 2368 18879975 SGTC_559 1550-0661 158 µM 0.0120941982522334 0.49027396685579 no 1635 0.495175230589454 2362 5830875 SGTC_1684 st024538 14.6195 µM 0.0118011929611382 0.490393400264863 no 1636 0.495292114445303 2383 6732859 SGTC_422 cantharidin 155 µM 0.0115671668262616 0.490488793492863 no 1637 0.495385470992273 2387 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_979 1426-2828 121 µM 0.0114278109606122 0.490545597688824 no 1638 0.495441062264568 2371 747872 SGTC_3290 9121031 71.43 µM 0.0112715473021189 0.490609294062214 no 1639 0.495503398429715 2382 17014854 SGTC_395 anisomycin 6.25 µM 0.00927507984449842 0.491423116953134 no 1640 0.496299831548471 2368 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1710 st031758 61.5 µM 0.00927087711403583 0.491424830157023 no 1641 0.496301508123261 2391 5394341 SGTC_2925 9010536 32.5 µM 0.0091992766423651 0.491454017446017 no 1642 0.496330071360644 2376 2994177 SGTC_514 4466-0038 2.65 nM 0.00726663134663859 0.492241859712301 no 1643 0.497101059032338 2359 5722064 SGTC_1737 st035557 69.7 µM 0.00647535111058385 0.492564433766502 no 1644 0.497416726714405 2396 5716916 SGTC_625 k213-0058 121 µM 0.00464916134635567 0.493308918233861 no 1645 0.498145259652143 2387 3655420 SGTC_2015 5119600 184 µM 0.00446930973670186 0.493382239808486 no 1646 0.498217009317615 2392 2828786 SGTC_3335 9143315 29.6265 µM 0.0044614982995692 0.493385424365945 no 1647 0.498220125599088 2385 4899691 SGTC_468 gf-109203x 121 µM 0.00414194650743618 0.493515699221976 no 1648 0.498347607139689 2396 2396 A protein kinase C inhibitor. SGTC_2105 5350118 200 µM 0.00403746835085605 0.493558293021471 no 1649 0.49838928754514 2391 2133313 SGTC_817 1391-0715 46 µM 0.0040094903703628 0.493569699135773 no 1650 0.498400449054135 2395 1353946 SGTC_1235 benzylparaben 21.5 µM 0.00354061116083906 0.493760853445254 no 1651 0.49858750346064 2391 7180 SGTC_2679 rapamycin 1 nM 0.00294209737587287 0.494004859705742 no 1652 0.498826274656989 2398 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_873 0591-4978 488 µM 0.00238794868177751 0.494230780899451 no 1653 0.499047347212795 2396 3305145 SGTC_2867 9039098 71.43 µM 0.00203235321643205 0.494375754794571 no 1654 0.499189208931412 2403 6463460 SGTC_2482 5981709 142.65 µM 0.00143606477925693 0.49461885926347 no 1655 0.499427093239075 2404 877755 SGTC_2408 sulbentine 18.36 µM 0.000714629255196958 0.494912988374503 no 1656 0.499714904199556 2398 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3167 9103034 49.47 µM 0.00024952414228644 0.495102613107151 no 1657 0.499900454270694 2404 5127859 SGTC_880 0833-0487 87.2 µM 0.000115172829138512 0.495157388743488 no 1658 0.499954052689005 2404 76075 SGTC_297 0986-0032 24 µM 0.000109563501031052 0.49515967569385 no 1659 0.499956290487137 2405 2847425 SGTC_2733 amorolfine 100 µM -0.000102720272748258 0.49524622493755 no 1660 0.499959020540218 2407 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_884 0851-0618 334 µM -0.000199197665566835 0.495285559367053 no 1661 0.499920531629574 2406 9642473 SGTC_1964 st076914 61 µM -0.000824328594968802 0.495540430205456 no 1662 0.499671140507767 2408 24208661 SGTC_483 fpl-64176 144 µM -0.00212164435013982 0.49606936181878 no 1663 0.499153586999758 2409 3423 SGTC_1914 st062367 72.6 µM -0.00296218574743283 0.496412064647106 no 1664 0.498818260591151 2410 978205 SGTC_2592 piperlongumine 83.33 µM -0.0048597851261383 0.497185757093894 no 1665 0.498061233870992 2418 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1699 st031318 29.054 µM -0.00631179935348869 0.497777782107258 no 1666 0.497481973091694 2432 5340658 SGTC_3126 9127922 49.47 µM -0.00669324023715499 0.497933306616409 no 1667 0.497329803413759 2431 45595682 SGTC_2071 5230951 39.92 µM -0.00672004618219224 0.497944236189597 no 1668 0.497319109629419 2417 1799272 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.00685285041178615 0.497998384407494 no 1669 0.497266129627291 2414 97141 SGTC_3215 9129942 49.47 µM -0.00786448135502475 0.498410857444361 no 1670 0.496862558215916 2421 17682944 SGTC_420 mitomycin C 81.9 mM -0.00804507693852157 0.498484492007339 no 1671 0.496790513281587 2425 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2680 butyl paraben 22.24 µM -0.00839740666760706 0.498628148189565 no 1672 0.496649958806775 2417 7184 An antifungal and steroid mimetic. SGTC_3229 9132204 49.47 µM -0.0085166226826872 0.498676756441131 no 1673 0.496602400198639 2422 17682924 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.0100689120868006 0.499309676910058 no 1674 0.49598315312437 2426 688662 SGTC_1410 3909-8106 77.9 µM -0.0102018943881514 0.499363898359218 no 1675 0.495930103586719 2428 1039210 SGTC_1665 st014639 11.4 µM -0.0103527887972436 0.499425423203751 no 1676 0.495869908606207 2425 981133 YIL048W NEO1 SGTC_2670 beta-carotene 100 µM -0.010366692672781 0.499431092293104 no 1677 0.495864362060041 2432 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_3101 9120531 49.47 µM -0.0111724952743395 0.499759645950619 no 1678 0.495542911983416 2420 24824904 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.0123514675394719 0.499759645950619 no 1679 0.495072602660081 2431 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2066 5222451 176 µM -0.0125936575950449 0.499660896641038 no 1680 0.494975990322289 2426 2281147 SGTC_2775 cyproheptadine 69.59 µM -0.0127775201310168 0.499585929503512 no 1681 0.494902645684711 2427 2913 A selective serotonin reuptake inhibitor. SGTC_199 4063-0024 41.6 µM -0.0130006828853803 0.49949493832279 no 1682 0.494813624021613 2477 306215 SGTC_2052 5265182 7.135 µM -0.013230924878345 0.499401060719001 no 1683 0.494721778656256 2427 1239884 SGTC_1578 josamycin 24.2 µM -0.0135789630157925 0.499259153627826 no 1684 0.494582944003072 2435 5282165 A P450 substrate. SGTC_767 0929-0023 86 µM -0.014501835631255 0.498882867296852 no 1685 0.494214807398093 2430 1204563 SGTC_2950 9072895 21.46 µM -0.0149239958313767 0.498710738637919 no 1686 0.49404640807409 2443 17332245 SGTC_1793 st048256 72.231 µM -0.0151565815494875 0.498615905858064 no 1687 0.493953630291764 2429 672022 SGTC_1478 0453-0656 35.7 µM -0.0152717937688866 0.498568930108788 no 1688 0.49390767258551 2434 5258496 SGTC_2991 9074669 71.4286 µM -0.0161407927415151 0.498214611798189 no 1689 0.493561034922861 2446 17333109 SGTC_1912 st060209 90.8 µM -0.0164269416324009 0.498097940157795 no 1690 0.49344689316635 2441 688787 SGTC_3264 9137442 49.47 µM -0.0166594658463148 0.498003133054987 no 1691 0.493354142119222 2443 17015726 SGTC_3091 9116372 49.47 µM -0.0176348249458348 0.49760545115888 no 1692 0.492965087351308 2525 17169793 SGTC_19 0279-0214 38.434 µM -0.0182832693599303 0.497341063054343 no 1693 0.49270643717681 2448 3566274 YBR002C RER2 SGTC_508 roscovitine 141 µM -0.0190974910207871 0.497009084807028 no 1694 0.492381666470726 2432 160355 A CDKinase inhibitor. SGTC_82 0054-0107 293.755 µM -0.0198926726011063 0.496684871667379 no 1695 0.492064495203595 2511 3104697 SGTC_439 amiodarone 34.4 µM -0.0201212863778702 0.496591661163751 no 1696 0.491973309754007 2485 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2695 st077686 51.995 µM -0.0202189734936695 0.496551832188934 no 1697 0.491934346159946 2456 2876092 SGTC_2974 9094440 9.66 µM -0.0203596927082788 0.496494458234373 no 1698 0.491878218869406 2598 25236134 SGTC_1629 st005085 44.9 µM -0.0208859517537169 0.496279892861319 no 1699 0.491668316528721 2443 24207091 SGTC_2310 7668677 200 µM -0.0216285747216327 0.495977113831777 no 1700 0.491372119764187 2462 2197143 SGTC_2488 5268135 45.7 µM -0.0219500586274833 0.495846040510494 no 1701 0.491243896684353 2460 1270356 YLR208W SEC13 SGTC_2237 6667747 47.222 µM -0.0227684427445058 0.495512376332719 no 1702 0.490917490268942 2473 729940 YDL015C TSC13 SGTC_946 3434-1334 87.4 µM -0.022824094702422 0.495489686530643 no 1703 0.49089529411803 2468 4047976 SGTC_1055 3448-0672 86 µM -0.0235168961982094 0.4952072263958 no 1704 0.490618980497419 2500 748378 SGTC_2618 avocadyne 43.43 µM -0.0243588436940693 0.494863961615942 no 1705 0.490283188275243 2452 3015189 SGTC_2146 5545642 200 µM -0.024774513168622 0.494694493182193 no 1706 0.490117410181251 2444 825326 SGTC_1562 morin hydrate 59.1 µM -0.0257239873030572 0.494307396243309 no 1707 0.489738745542354 2500 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_995 3931-2021 34.6 µM -0.0272446229519219 0.493687450279159 no 1708 0.489132312466308 2473 730143 SGTC_2887 9044784 58.44 µM -0.0287395645399548 0.493077994346639 no 1709 0.488536150724807 2465 6465546 SGTC_3106 9121286 49.47 µM -0.0288374646233609 0.493038083110301 no 1710 0.488497110423533 2576 15943471 SGTC_3115 9123671 49.47 µM -0.0289373128986055 0.492997377720229 no 1711 0.488457293341699 2448 3286988 SGTC_520 3584-0023 682 µM -0.0315998184618019 0.491911975812289 no 1712 0.487395594082639 2524 1340790 SGTC_39 0986-0283 58.349 µM -0.0325274576665355 0.491533826366751 no 1713 0.487025709779796 2475 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1527 coumarin 137 µM -0.032627877721473 0.491492890871434 no 1714 0.486985669227344 2595 323 A hepatotoxic, DNA x-linker. SGTC_43 0570-0105 72.5 µM -0.0332090891642688 0.491255966083692 no 1715 0.486753925008336 2475 1114046 YDL195W SEC31 SGTC_2743 auranofin 4.32 µM -0.0346615284041765 0.490663908033431 no 1716 0.48617481918335 2488 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_130 0136-0219 337.655 µM -0.036697469923482 0.489834031769604 no 1717 0.48536311299725 2462 234244 SGTC_1405 3909-7894 12 µM -0.0377360599986846 0.489410705660963 no 1718 0.484949062370351 2501 7104060 SGTC_1176 0848-0131 83.3 µM -0.0379846568612217 0.489309380098584 no 1719 0.484849957625529 2499 6769040 SGTC_2156 5649887 115 µM -0.0385288085429725 0.489087591803524 no 1720 0.484633031317742 2529 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_756 0508-1999 28.3 µM -0.0402521870122106 0.488385190449049 no 1721 0.483946036047793 2487 6753853 SGTC_2025 5147754 141 µM -0.0407387518174204 0.488186886531138 no 1722 0.483752083871409 2504 315777 YLR208W SEC13 SGTC_1149 3909-7961 23.3 µM -0.0409770155835923 0.488089781025342 no 1723 0.483657109687881 2487 735261 SGTC_1456 k015-0012 13 µM -0.0410497303824467 0.488060145911311 no 1724 0.483628125067935 2476 2989616 SGTC_1590 st077108 57.8 µM -0.04185400328109 0.48773236673787 no 1725 0.483307542152625 2461 5489485 SGTC_1201 1889-3372 45.9 µM -0.041927632849218 0.487702359623712 no 1726 0.483278193966813 2527 5392199 SGTC_2103 5378138 10 µM -0.0420982963380801 0.487632807415384 no 1727 0.483210169146904 2471 244142 SGTC_165 k038-0023 64.381 µM -0.0428279568852112 0.487335445780821 no 1728 0.482919339029371 2498 46368543 SGTC_675 1309-0189 238 µM -0.0430531617909849 0.487243668491697 no 1729 0.482829578063799 2511 4246530 SGTC_2234 tolnaftate 200 µM -0.043157434037034 0.487201174867602 no 1730 0.482788018084744 2470 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2295 7971645 200 µM -0.043439376043109 0.48708627697232 no 1731 0.482675644883592 2527 2978226 YKL099C UTP11 SGTC_1288 0973-0013 65.5 µM -0.0441199110159809 0.486808947649119 no 1732 0.482404410770846 2540 4315430 SGTC_324 1315-0088 19.6 µM -0.0450945619641763 0.486411772316739 no 1733 0.482015967969468 2473 6787421 SGTC_2440 5628896 157.78 µM -0.0452752903439303 0.486338126031262 no 1734 0.481943941342729 2507 5522048 SGTC_2529 gangaleoidin 93.61 µM -0.0453000981894081 0.486328016943193 no 1735 0.481934054588228 2511 4565183 SGTC_60 0986-0278 202 µM -0.0454074854827526 0.486284257194243 no 1736 0.481891257295495 2476 3110598 SGTC_1742 st038235 28.8875 µM -0.0454671407240212 0.486259948073107 no 1737 0.481867482851937 2553 564103 YBR002C RER2 SGTC_2207 7258803 200 µM -0.0455522772457434 0.486225255585085 no 1738 0.48183355344819 2485 3666799 SGTC_3105 9121040 49.47 µM -0.0458388823566958 0.486108466940015 no 1739 0.481719333864473 2483 41448907 SGTC_272 doxorubicin 8.13 µM -0.0461467234283571 0.485983026186043 no 1740 0.48159665287035 2466 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1120 ficusin 1.78878 µM -0.0466080533139908 0.485795043575978 no 1741 0.481412806695628 2602 6199 A DNA cross-linker. SGTC_1257 0669-0121 16 µM -0.0478805562223458 0.485276540832384 no 1742 0.48090571775106 2550 4307855 SGTC_2023 5144124 124 µM -0.0479394447023231 0.485252546325215 no 1743 0.480882251593768 2506 2830192 SGTC_1989 st071868 50.2 µM -0.0482814808525404 0.485113182454245 no 1744 0.480745956739162 2487 16414057 SGTC_3066 9117245 49.47 µM -0.0484361545938658 0.485050160672939 no 1745 0.480684322953913 2513 17176980 SGTC_2560 caryophyllene 100 µM -0.0488172539239959 0.484894883432915 no 1746 0.480532465962391 2499 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2260 7964312 200 µM -0.0500513572493636 0.484392069318444 no 1747 0.480040731204456 2637 231951 SGTC_381 3461-2219 42.7 µM -0.0503845080968074 0.484256336972542 no 1748 0.479907990727013 2514 2883159 SGTC_67 0335-0847 266 µM -0.0504686786182224 0.484222044499786 no 1749 0.479874454213401 2680 4552207 YOR254C SEC63 SGTC_909 3448-9333 149 µM -0.0517742862342118 0.483690133306485 no 1750 0.479354272338166 2503 3344074 SGTC_2340 7987427 183.45 µM -0.0531981354527639 0.483110083001273 no 1751 0.478787020603372 2549 2239331 SGTC_1244 0416-0015 52.5 µM -0.0533905493475618 0.483031699790628 no 1752 0.478710367501255 2523 96201 SGTC_3287 9117173 37.0625 µM -0.0547387970070883 0.482482485775852 no 1753 0.478173280070213 2494 2789709 SGTC_362 0310-0100 9.03 µM -0.0549667899544508 0.482389615204627 no 1754 0.478082460776758 2551 790235 SGTC_2943 9068529 45.32 µM -0.0551782099006649 0.482303496327968 no 1755 0.477998244231895 2488 3270634 SGTC_2913 7966556 36.57 µM -0.0554181997961162 0.482205740893926 no 1756 0.477902648388609 2500 2976516 SGTC_259 usnic acid 108.925 µM -0.0556651814204008 0.482105138625876 no 1757 0.477804268838062 2604 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2411 st077133 39.94 µM -0.0557588502012545 0.482066985106129 no 1758 0.477766958348677 2764 1403142 YNL221C POP1 SGTC_323 4013-0906 34.3 µM -0.0559888716453526 0.481973292604897 no 1759 0.477675336198169 2597 2910086 SGTC_2699 st077704 54.6 µM -0.0560216628937857 0.481959936130794 no 1760 0.477662274882809 2545 645852 SGTC_1822 st052468 42 µM -0.0564988559020759 0.481765569006238 no 1761 0.477472203464469 2527 2873678 SGTC_151 3013-0144 2.285 µM -0.0569009061743617 0.481601811890128 no 1762 0.477312066230797 2697 906558 YHR107C CDC12 SGTC_1725 st036284 20.55 µM -0.0579834521104105 0.481160900946545 no 1763 0.476880904825486 2515 707914 SGTC_2586 curcumin 80 µM -0.0580229109895951 0.48114483014217 no 1764 0.476865189468621 2572 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2836 9010338 19.48 µM -0.0580470346404146 0.481135005081609 no 1765 0.476855581717714 2522 2994051 SGTC_1242 0402-0103 60.1 µM -0.0580476939971172 0.481134736539518 no 1766 0.47685531911524 2512 432868 SGTC_2650 prasterone 100 µM -0.0595996982081417 0.480502661916199 no 1767 0.476237229369105 2505 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_944 3370-0224 231 µM -0.0603637773921408 0.48019149828274 no 1768 0.475932953739823 2527 4580514 SGTC_3150 9097574 49.47 µM -0.0604677889514572 0.480149141540847 no 1769 0.475891534791166 2527 17217476 SGTC_2858 9025781 8.96 µM -0.0607663998098022 0.48002753915913 no 1770 0.475772624958685 2558 4894980 YPL153C RAD53 SGTC_1321 1326-2144 215 µM -0.0624859462221629 0.479327330078871 no 1771 0.475087926679595 2593 3513030 SGTC_467 ro 31-8220 72.8 µM -0.063773796754095 0.478802951678552 no 1772 0.474575171467993 2534 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1375 2910-0797 186 µM -0.0639929038105522 0.478713740753972 no 1773 0.474487938583443 2562 742508 SGTC_117 lucigenin 22.078 µM -0.065074002758121 0.478273579680747 no 1774 0.474057539671075 2538 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1440 4100-1550 40 µM -0.0663131719449834 0.477769094158148 no 1775 0.473564248306419 2529 742806 SGTC_2180 6301957 200 µM -0.0663288311322722 0.477762719279681 no 1776 0.47355801491832 2524 845462 SGTC_1422 4031-0024 15.5 µM -0.0666909939055216 0.477615283866201 no 1777 0.473413852086429 2519 782427 SGTC_3240 9133527 49.47 µM -0.0668686882731995 0.47754294612414 no 1778 0.473343120182364 2502 17617455 SGTC_900 1112-0045 141 µM -0.0670900344932178 0.477452839149793 no 1779 0.473255013671844 2538 56211 YIL048W NEO1 SGTC_2625 euphol 100 µM -0.0678996923206425 0.477123248538957 no 1780 0.472932741841042 2556 6708538 A triterpene alcohol. SGTC_652 0437-0092 114 µM -0.0684463005178074 0.476900747414652 no 1781 0.472715182869847 2526 3091274 SGTC_254 nsc-64875 3.808 µM -0.06901057802176 0.476671061416218 no 1782 0.472490599765672 2650 56993 SGTC_1185 1319-0113 81.3 µM -0.0690413956940999 0.476658517477757 no 1783 0.472478334547373 2597 4672763 SGTC_1448 4255-0083 152 µM -0.0718205970729466 0.475527375796883 no 1784 0.47137234052698 2663 5399660 SGTC_27 0485-0001 32.618 µM -0.0721008924425883 0.475413305699738 no 1785 0.471260808004714 2521 2054479 SGTC_2309 7664088 163.95 µM -0.0742166068665981 0.474552351973422 no 1786 0.470419015962049 2558 704922 SGTC_961 1252-1571 372 µM -0.0743016241077917 0.474517758120659 no 1787 0.470385192377331 2575 6813498 SGTC_2705 st078069 42.8 µM -0.0749222298349899 0.474265237024678 no 1788 0.470138294706792 2599 1530061 SGTC_169 k015-0017 16.025 µM -0.0759174269760809 0.47386031834504 no 1789 0.469742396074357 2570 1840002 SGTC_1247 0448-0043 5.84 µM -0.0762204540616715 0.473737030200296 no 1790 0.469621855017701 2602 3089013 YGL099W LSG1 SGTC_310 1273-0058 1.06 µM -0.0784357441492395 0.472835805078646 no 1791 0.468740720691 2560 2734232 SGTC_3120 9124077 49.47 µM -0.0809144422910682 0.471827585226695 no 1792 0.467754997169918 2532 18774327 YGL155W CDC43 SGTC_1077 5-fluorocytosine 377 nM -0.0809628419221245 0.471807900269287 no 1793 0.467735751653395 2621 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1709 st033179 39.1045 µM -0.0825411347619381 0.471166019604972 no 1794 0.467108204551702 2534 573381 SGTC_1781 st038725 66.3 µM -0.084856529792499 0.470224500631573 no 1795 0.46618772564144 2564 4270275 YIL048W NEO1 SGTC_587 k089-0003 57 µM -0.0851028123010536 0.470124363423994 no 1796 0.466089827263798 2550 9659696 SGTC_1367 1812-0510 76.9 µM -0.0858425271941427 0.469823610518675 no 1797 0.465795799708669 2602 1142582 YDR527W RBA50 SGTC_1230 0170-0365 3.77 µM -0.0866751314131754 0.469485111320094 no 1798 0.465464872132819 2635 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1559 coumarin 343 70.1 µM -0.0876512171849458 0.469088307114322 no 1799 0.465076946683052 2636 108770 A hepatotoxic, DNA x-linker. SGTC_1834 st055981 52.8 µM -0.087887234011419 0.468992364741732 no 1800 0.46498315156136 2714 471719 YDL150W RPC53 SGTC_3146 9095609 49.47 µM -0.0895596648191374 0.468312562665878 no 1801 0.464318569179283 2631 17173999 SGTC_2859 9028643 45.46 µM -0.091423134761934 0.467555216776579 no 1802 0.46357818992113 2668 17151580 SGTC_2605 digitonin 300 nM -0.0919954967158075 0.467322622586668 no 1803 0.46335080876035 2560 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2806 7952793 58.44 µM -0.0922164359445576 0.467232841155925 no 1804 0.463263039845678 2674 2972490 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.0923466725329494 0.467179918663034 no 1805 0.463211303723247 2620 4213774 SGTC_2461 5755302 26.15 µM -0.0925273676260738 0.467106492986501 no 1806 0.463139524130899 2691 2788904 SGTC_480 am 92016 50 µM -0.0931836937411332 0.466839803485555 no 1807 0.462878814264441 2638 2129 K+ channel blocker. SGTC_1925 st057770 10.1 µM -0.094833888158904 0.466169334680164 no 1808 0.462223384652416 2575 5989122 SGTC_1777 st045864 34.765 µM -0.095226056169226 0.466010012097525 no 1809 0.462067637097562 2587 4691462 SGTC_558 k064-0027 21.3 µM -0.0953105972887535 0.465975667047462 no 1810 0.462034062777963 2654 5088526 SGTC_862 0452-0056 10.2 µM -0.0955318360856939 0.46588578940971 no 1811 0.46194620217443 2578 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1734 st037168 69.4 µM -0.0964418859033292 0.465516102584433 no 1812 0.461584813501117 2678 708907 SGTC_1296 1068-0102 11.9 µM -0.098235604146556 0.464787533197557 no 1813 0.460872605579452 2673 767053 SGTC_797 k781-0471 270 µM -0.100091450578468 0.464033852957321 no 1814 0.46013586134892 2635 23738129 SGTC_842 0271-0008 11.1 µM -0.100570116776139 0.463839482022854 no 1815 0.459945859879596 2704 1221709 SGTC_1606 st000094 49.2 µM -0.101004856504931 0.463662955691118 no 1816 0.459773302480817 2581 1242210 SGTC_2387 9077560 195.08 µM -0.101409771097052 0.463498546308082 no 1817 0.459612590124388 2564 5303272 SGTC_2912 7964298 10.93 µM -0.101768256813097 0.463352993862499 no 1818 0.45947031109671 2649 2975850 SGTC_1767 st044992 70.3 µM -0.102085436559389 0.463224216565101 no 1819 0.4593444302803 2618 9600693 SGTC_2284 7945075 39.21 µM -0.10219051430873 0.463181555079298 no 1820 0.459302728412074 2673 1245402 SGTC_545 4218-0007 221 µM -0.102549623327742 0.46303576029176 no 1821 0.459160213354331 2667 2840508 SGTC_749 1000-0129 128 µM -0.103441087948618 0.462673855782895 no 1822 0.458806451781207 2691 708470 SGTC_1297 1068-0111 14.1 µM -0.10370985562911 0.462564751235416 no 1823 0.458699802586957 2576 767057 SGTC_1977 st070720 65.3 µM -0.105071994124565 0.462011843167591 no 1824 0.458159340859733 2699 682188 SGTC_1499 4480-0877 67.3 µM -0.105115907747718 0.461994019326084 no 1825 0.458141918338522 2590 2861909 SGTC_317 4495-0002 170 µM -0.105118099294815 0.461993129813957 no 1826 0.458141048854737 2627 15991618 SGTC_720 r052-1644 49.9 µM -0.106231182295844 0.461541372798775 no 1827 0.457699465512203 2682 1422863 YOR257W CDC31 SGTC_1142 3253-1408 9.78 µM -0.106568563361089 0.461404452743876 no 1828 0.457565629662799 2573 256655 SGTC_1132 3456-3614 2.5 µM -0.106757586474078 0.461327743101769 no 1829 0.457490648099693 2801 3125502 SGTC_1214 0358-0031 63.7 µM -0.106940685455203 0.461253438971542 no 1830 0.457418017959956 2884 4301366 SGTC_1855 st056195 39.6 µM -0.108121061973177 0.46077445823222 no 1831 0.456949830526487 2654 4028379 SGTC_684 1140-0066 328 µM -0.109553397825941 0.460193312307015 no 1832 0.456381785626373 2650 6813534 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.110033767338609 0.459998429520229 no 1833 0.456191297518318 2575 756377 SGTC_2896 9052656 71.43 µM -0.111706204487225 0.459320007915349 no 1834 0.455528179827625 2604 6469436 SGTC_3317 9138495 8.753 µM -0.112312993456243 0.459073894064969 no 1835 0.455287619850189 2608 17020139 SGTC_350 k064-0020 19.8 µM -0.112943164188797 0.458818313166294 no 1836 0.455037807585351 2702 2790705 SGTC_2222 6885208 172.143 µM -0.114238269050697 0.458293105792049 no 1837 0.45452445807616 2632 609514 SGTC_2336 9001819 198.65 µM -0.115872098874502 0.457630638340176 no 1838 0.453876954295534 2755 2989602 SGTC_2054 5233173 129 µM -0.116197459634662 0.457498728611284 no 1839 0.453748025017026 2710 6889 SGTC_2215 7188065 200 µM -0.116233831751118 0.45748398269834 no 1840 0.453733612300943 2725 940217 SGTC_542 3381-0244 89.3 µM -0.116542825615047 0.457358713367743 no 1841 0.453611173691102 2776 1112843 SGTC_2423 st077119 87.2 µM -0.117844851000752 0.456830905397805 no 1842 0.453095295579729 2554 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1685 st024049 53.0905 µM -0.118027480709614 0.45675687802785 no 1843 0.453022941803192 2679 1941139 SGTC_3139 9095020 49.47 µM -0.118911023116405 0.456398763007276 no 1844 0.452672924272073 2577 25236292 SGTC_1457 k015-0032 57.3 µM -0.119156861698461 0.456299126662579 no 1845 0.452575541231444 2600 4302660 SGTC_48 0382-0018 55 µM -0.119666930616821 0.456092408719284 no 1846 0.452373498805198 2797 762596 SGTC_2517 totarol 10 µM -0.119726806993269 0.45606814312706 no 1847 0.452349782095729 2677 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.121096876623848 0.455512951554225 no 1848 0.451807151532142 2591 5355888 SGTC_2385 9074692 200 µM -0.121782883219305 0.455234994543446 no 1849 0.451535485125533 2653 17046906 SGTC_603 3794-0023 45.9 µM -0.12260697552122 0.454901116778352 no 1850 0.451209165228633 2635 3802260 SGTC_25 0118-0223 35.662 µM -0.124524864783823 0.454124215202585 no 1851 0.450449857172987 2667 5333628 SGTC_419 nsc-638432 893 µM -0.127250833992277 0.453020278023582 no 1852 0.449370936327466 2690 368090 SGTC_2160 5660466 132.927 µM -0.127695282565786 0.452840323642405 no 1853 0.449195061748495 2599 2859134 SGTC_943 3253-1379 105 µM -0.128811808664392 0.452388292184208 no 1854 0.448753280707882 2751 668464 SGTC_1570 verbenone 133 µM -0.128902418103145 0.452351611175918 no 1855 0.448717431632452 2734 29025 A natural terpanoid with antifungal properties. SGTC_2903 5923464 63.88 µM -0.128930794121134 0.452340123924814 no 1856 0.44870620491895 2649 2876576 SGTC_2765 myclobutanil 7.74 µM -0.129552092310985 0.452088618442139 no 1857 0.448460404249856 2727 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_819 1013-0258 27.7 µM -0.130114493223523 0.451860971529471 no 1858 0.44823792183259 2652 5753198 SGTC_391 gliotoxin 8.33 µM -0.131260684418376 0.451397068858257 no 1859 0.447784545965507 2762 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1949 st076024 69.1 µM -0.132191550227804 0.451020364522346 no 1860 0.447416392205408 2601 2921930 SGTC_3004 9076122 71.4286 µM -0.133300926258376 0.450571478007579 no 1861 0.446977697545235 2745 44782551 SGTC_2029 5175081 200 µM -0.133455035063043 0.450509125992772 no 1862 0.446916761461957 2636 1380876 SGTC_1263 0774-1208 64.8 µM -0.133689493161028 0.450414267209614 no 1863 0.446824056910053 2698 906585 SGTC_3308 9128332 17.569 µM -0.137563144691258 0.448847450765617 no 1864 0.44529284240613 2787 17332805 YDL196W YDL196W SGTC_3309 9129340 25.759 µM -0.137942129363258 0.448694201293274 no 1865 0.44514307711731 2711 17158987 SGTC_1516 st013856 110 µM -0.138178614961757 0.448598577838082 no 1866 0.445049627873391 2786 5281404 A mutagen and neurotoxin. SGTC_408 cantharidin 100 µM -0.139261440730445 0.448160773155986 no 1867 0.444621779377449 2701 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2306 7482397 179.52 µM -0.140056960811606 0.447839171197223 no 1868 0.444307492816044 2773 891448 SGTC_1007 4101-0031 70 µM -0.140292977703174 0.4477437641072 no 1869 0.444214256217727 2763 1146276 SGTC_2712 st079126 47.7 µM -0.142547372495266 0.446832604303709 no 1870 0.443323831769342 2638 3152970 SGTC_806 3966-4455 5.86 µM -0.144215905302871 0.446158413028023 no 1871 0.442664990811381 2678 714982 SGTC_2564 betulinic acid 100 µM -0.145333464127642 0.445706936495425 no 1872 0.442223797324098 2856 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_3313 9133968 57.047 µM -0.145386941044384 0.445685334405833 no 1873 0.442202687326028 2636 1494643 SGTC_668 1682-0499 62.6 µM -0.145606076476854 0.445596815967713 no 1874 0.442116185389647 2696 682214 SGTC_2443 5493264 126.67 µM -0.145665710163871 0.44557272776824 no 1875 0.44209264595246 2792 5340055 SGTC_118 0083-0097 135.343 µM -0.147690221318451 0.444755074377449 no 1876 0.441293624629773 2693 5207356 SGTC_2419 paclitaxel 166.5 µM -0.148044915465316 0.444611845682893 no 1877 0.441153660676509 2620 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1113 artemisinin 1.17947 µM -0.148098155397097 0.44459034754218 no 1878 0.441132652586773 2688 2240 An anti-malaria and mitochondrial poison. SGTC_1043 0916-0009 19.3 µM -0.14838115808138 0.44447607455988 no 1879 0.441020984568356 2667 3101130 SGTC_3124 9127567 49.47 µM -0.148387457430716 0.444473531013032 no 1880 0.441018499006176 2816 17592030 SGTC_885 0865-0106 16.8 µM -0.148611123070074 0.444383220941091 no 1881 0.440930247770261 2666 2793380 SGTC_1280 0880-0253 10.1 µM -0.1501913174702 0.443745264159097 no 1882 0.440306837925488 2703 6836607 SGTC_3176 9106582 49.47 µM -0.15053423332036 0.44360684121095 no 1883 0.440171572080777 2667 17018027 SGTC_2584 androsterone 48.74 µM -0.150637654451767 0.443565095123502 no 1884 0.440130778174677 2726 2754130 A steroid. SGTC_2749 bexarotene 57.39 µM -0.15096716643432 0.443432091319839 no 1885 0.440000808195027 2775 82146 An retinoic acid receptor inhibitor. SGTC_2262 9014885 67.46 µM -0.151622145872874 0.443167735177288 no 1886 0.439742482736665 2699 6457424 SGTC_1713 st033146 12.748 µM -0.15179830921066 0.44309663823342 no 1887 0.439673007867722 2769 674619 SGTC_2825 7998094 58.44 µM -0.153258576612733 0.442507366436566 no 1888 0.439097182883838 2757 2987815 SGTC_1039 k821-0043 94 µM -0.154767967929597 0.441898405000437 no 1889 0.438502122386111 2786 15992768 SGTC_206 4546-0025 72.014 µM -0.155635983009534 0.441548267834749 no 1890 0.438159980098129 2703 6620745 YIL048W NEO1 SGTC_2281 7943571 200 µM -0.156362727938758 0.441255150890014 no 1891 0.437873557278911 2777 1244024 SGTC_3045 9092950 49.47 µM -0.156834107751309 0.44106504716794 no 1892 0.437687795686438 2704 44120432 SGTC_1236 0330-0013 258 µM -0.157728096696018 0.440704545883134 no 1893 0.437335529827793 2739 4617066 SGTC_886 0866-0150 153 µM -0.158423933282377 0.44042398358192 no 1894 0.437061377942986 2874 271463 SGTC_351 caspofungin 25 nM -0.159204426110318 0.440109323355988 no 1895 0.436753908404325 2719 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2677 mitomycin C 100 µM -0.159259609453989 0.440087077299132 no 1896 0.436732170766685 2696 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1622 st003707 19.4 µM -0.159304461961963 0.440068996050569 no 1897 0.436714502757928 2802 10140899 SGTC_1394 3474-0001 65.7 µM -0.159396118801773 0.440032047109631 no 1898 0.436678398283245 2750 5017666 YIL048W NEO1 SGTC_2880 9042983 58.44 µM -0.159630889958347 0.439937407940176 no 1899 0.436585922165615 2831 6464714 SGTC_2248 tofa 1.1 µM -0.159979138606265 0.439797030906788 no 1900 0.43644875376525 2674 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2059 5238311 157 µM -0.161450209096821 0.439204134542584 no 1901 0.43586941209049 2698 703021 SGTC_3086 9117350 49.47 µM -0.16314787291694 0.438520082167924 no 1902 0.435201003785388 2691 2679265 SGTC_3292 9120825 59.784 µM -0.163742350077637 0.438280588344091 no 1903 0.434966988461959 2729 24824900 SGTC_2738 aclarubicin 5.55 µM -0.16413178426216 0.438123711330873 no 1904 0.434813700438738 2773 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2704 st078022 71.1 µM -0.165342202227699 0.437636176991529 no 1905 0.434337321668334 2839 54697681 SGTC_1291 0993-0025 5.79 µM -0.166125677119787 0.437320657976186 no 1906 0.434029023748397 2812 4353356 SGTC_3225 9130819 49.47 µM -0.166322772159488 0.437241290629954 no 1907 0.433951473021238 2716 4547121 SGTC_389 tpck 16.7 µM -0.166535430530177 0.437155658986094 no 1908 0.433867801461917 2762 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_325 2810-4341 181 µM -0.166670812815664 0.437101145817772 no 1909 0.433814536129975 2825 774970 SGTC_2147 5545932 89.7195 µM -0.167754906026014 0.436664666900536 no 1910 0.433388049714724 2731 797404 SGTC_2050 5263056 171 µM -0.169001040210131 0.436163042125676 no 1911 0.432897911599854 2822 763468 YGL055W OLE1 SGTC_2634 4'-methoxyflavone 100 µM -0.169022592967184 0.436154367077301 no 1912 0.432889435226265 2763 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1409 3909-8004 61.9 µM -0.169083551134693 0.436129831401118 no 1913 0.432865461467522 2741 2119279 SGTC_49 0717-0965 32.132 µM -0.170037007390348 0.435746097088937 no 1914 0.432490516361173 2991 5889349 YGL099W LSG1 SGTC_1472 k841-0093 193 µM -0.170482697863182 0.435566742276048 no 1915 0.432315270141604 2811 X1472 SGTC_2393 9031399 185.94 µM -0.170595887017604 0.435521194791889 no 1916 0.432270766100635 2849 1526623 YDL150W RPC53 SGTC_978 1416-0512 87.4 µM -0.172154972576845 0.434893903732697 no 1917 0.431657847984621 2754 6814003 SGTC_141 0443-0274 32.331 µM -0.172256424138071 0.434853090814098 no 1918 0.431617970354408 2820 1627241 SGTC_2898 9056270 58.44 µM -0.175356324925198 0.433606369312497 no 1919 0.43039982821998 2691 19154699 SGTC_250 brefeldin a 552.239 µM -0.176379957990384 0.433194827855071 no 1920 0.429997724514372 2709 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1564 D-Arginine 115 µM -0.17643589451189 0.433172341218084 no 1921 0.429975753609073 2748 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2305 7443522 69.23 µM -0.176584274909507 0.43311269293455 no 1922 0.429917473387022 2731 5415886 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.17684625689295 0.433007381021795 no 1923 0.429814576945809 2879 688751 SGTC_3351 9150312 21.596 µM -0.176920587112298 0.432977502514212 no 1924 0.429785383763956 2684 4904905 SGTC_2451 5856223 45.7 µM -0.178427033745324 0.432372039179491 no 1925 0.429193810038461 2759 2179896 SGTC_2379 9035213 200 µM -0.178574057397161 0.432312956665755 no 1926 0.429136083112781 2816 646551 SGTC_2742 clothiapine 36.27 µM -0.179331701248647 0.432008516050756 no 1927 0.42883862815847 2747 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2533 agelasine 13.65 µM -0.180337800325081 0.431604302222338 no 1928 0.428443690870162 2871 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1736 st036774 51 µM -0.181087541131967 0.431303130313606 no 1929 0.42814943183087 3007 1272247 SGTC_1143 3454-2408 5.08 µM -0.181683400688509 0.431063801186961 no 1930 0.427915596745418 2694 X1143 SGTC_715 0868-0130 184 µM -0.183755146537859 0.430231874582034 no 1931 0.427102772371697 2860 2876258 SGTC_713 1488-1073 324 µM -0.184819444855906 0.429804616974299 no 1932 0.426685327904712 2721 3312542 SGTC_2345 9052315 157.45 µM -0.185499091585253 0.429531818929038 no 1933 0.426418796355959 2818 6469265 SGTC_1650 st011916 45.8 µM -0.186503534865442 0.429128714998314 no 1934 0.426024953534697 2795 242528 SGTC_985 1493-0307 8.71 µM -0.186791902376604 0.429013000767564 no 1935 0.425911898071271 2837 3278274 SGTC_2259 7964009 200 µM -0.186924144688211 0.42895993747653 no 1936 0.425860054059357 2909 313134 SGTC_2658 polymyxin b sulfate 77.05 µM -0.188080546900278 0.428495976594663 no 1937 0.425406755141256 2759 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1357 1503-1303 39.5 µM -0.188521595939576 0.428319049017575 no 1938 0.425233893954846 2762 292895 SGTC_192 3455-0609 60.9 µM -0.189072393405094 0.428098115906434 no 1939 0.425018039045197 2860 3769639 SGTC_2455 5377712 9.75 µM -0.189111464575563 0.428082444730153 no 1940 0.425002728092194 2817 2243908 SGTC_454 lyso-paf C-16 6.67 µM -0.189166107631015 0.428060527968746 no 1941 0.424981315121195 2809 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1800 st050079 29.0735 µM -0.189755424127083 0.427824173366246 no 1942 0.424750393778196 2831 3645560 SGTC_2824 7998404 51.95 µM -0.189988289288513 0.427730786282675 no 1943 0.424659153596997 2735 837851 SGTC_856 0433-0016 11.3 µM -0.191248487319335 0.427225473113805 no 1944 0.424165458619036 2823 3911780 SGTC_1721 st082152 9.2685 µM -0.191553408854902 0.427103223833507 no 1945 0.424046020454642 2720 5296051 SGTC_1792 st045773 43.6 µM -0.19240256782009 0.42676281556525 no 1946 0.423713440574993 2736 2919270 SGTC_631 k072-0230 41.5 µM -0.193823870023195 0.426193170415751 no 1947 0.423156897927543 2859 5773147 SGTC_1657 st012939 43.4 µM -0.194204792735877 0.426040526127348 no 1948 0.423007765127973 2892 24207257 SGTC_754 3474-0146 171 µM -0.194619620624262 0.425874307878022 no 1949 0.422845370862778 2737 24762078 SGTC_744 1594-0068 283 µM -0.195345597933705 0.425583446229206 no 1950 0.422561201304318 2799 668392 SGTC_1630 st005209 31.3 µM -0.195408003573446 0.425558445397058 no 1951 0.422536775721205 2739 3367314 SGTC_837 0091-0265 12.5 µM -0.196373079708716 0.42517185654045 no 1952 0.422159082654775 2755 759367 SGTC_2886 9058944 51.95 µM -0.197032200616596 0.424907868125658 no 1953 0.421901169614608 2744 4949929 SGTC_968 1309-0633 340 µM -0.197572479591266 0.424691502903776 no 1954 0.421689784221657 2855 3761976 SGTC_2919 7978188 46.38 µM -0.200186431510751 0.423645016589743 no 1955 0.420667389240232 2888 2980291 SGTC_3222 9128301 49.47 µM -0.200700141470993 0.42343941770128 no 1956 0.420466524544225 2795 4911358 SGTC_3061 glucosamine 200 µM -0.201532635613697 0.423106278118208 no 1957 0.42014105668166 2764 91431 and experimental redox chemotherapeutic SGTC_982 1491-0518 27.5 µM -0.203685796143996 0.422244902350937 no 1958 0.419299521273502 2788 3091256 SGTC_3307 9126885 69.2785 µM -0.203734587195748 0.422225387694534 no 1959 0.419280456172789 2764 24824909 SGTC_1373 2887-0003 58.5 µM -0.203916826248717 0.422152500351928 no 1960 0.419209247949372 2862 776948 SGTC_74 000s-0487 160.283 µM -0.205268689555151 0.421611899845686 no 1961 0.418681102645631 2735 677548 SGTC_984 1492-0255 2.91 µM -0.205741298644718 0.421422941630475 no 1962 0.418496498476912 2895 1585198 SGTC_763 3453-1109 128 µM -0.205875795894351 0.421369170345529 no 1963 0.418443966259991 2882 1560353 SGTC_339 3091-4833 71.4 µM -0.205877225881205 0.421368598652268 no 1964 0.41844340774055 2781 3240077 SGTC_624 k048-0052 28 µM -0.20662400709497 0.421070066283879 no 1965 0.418151754944006 2816 6835531 SGTC_864 0469-0573 172 µM -0.206708017754601 0.42103648511896 no 1966 0.418118947687124 2754 689425 SGTC_2159 5658611 73.75 µM -0.207179623431443 0.420847983188412 no 1967 0.417934790109454 2777 793844 SGTC_1343 1487-0095 224 µM -0.208050129619183 0.420500087448356 no 1968 0.417594912923169 2803 4560101 YGL055W OLE1 SGTC_2745 rifampicin 24.3 µM -0.208645535633818 0.420262170582973 no 1969 0.417362480252782 2855 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1979 st071809 45.3 µM -0.208783934673278 0.420206872211372 no 1970 0.417308456617104 2916 4976333 SGTC_1067 clotrimazole 1.36 µM -0.209218311213127 0.42003332404941 no 1971 0.417138909225221 2779 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1431 4049-0260 9.09 µM -0.209427491611522 0.419949754929211 no 1972 0.41705726668467 2743 3854841 SGTC_476 mead acid 10 µM -0.209930098440848 0.419748974535854 no 1973 0.41686111523344 2775 5312531 An omega 9 fatty acid. SGTC_2487 5918373 44.05 µM -0.210176771325857 0.419650441772391 no 1974 0.416764854224201 2768 2876279 SGTC_96 0929-0093 37.281 µM -0.211789013033201 0.419006560859959 no 1975 0.416135820212898 2769 6991579 SGTC_927 2425-1185 123 µM -0.212028533084673 0.418910922207303 no 1976 0.416042387088246 2755 730375 SGTC_95 0471-0001 561.058 µM -0.21258241884655 0.418689777925153 no 1977 0.415826342868773 2802 4015405 SGTC_3121 9125696 49.47 µM -0.212781707915186 0.418610216106263 no 1978 0.415748615998986 2768 1235365 SGTC_3177 9107506 49.47 µM -0.213150782580525 0.418462879881444 no 1979 0.415604677931633 2896 8897194 SGTC_1253 0550-0034 176 µM -0.213421749327962 0.418354716048407 no 1980 0.415499008879704 2900 5969915 SGTC_1802 st050112 57.9 µM -0.214233389573233 0.418030764484759 no 1981 0.41518252967985 2754 4662563 SGTC_2801 7907800 81.82 µM -0.214531630718017 0.417911740870029 no 1982 0.415066251676687 2877 6620925 SGTC_538 2922-0838 53.3 µM -0.215701620385605 0.41744488805692 no 1983 0.41461016903369 2927 777039 SGTC_186 3455-3465 67.277 µM -0.216077341089381 0.4172949914955 no 1984 0.414463730849937 2775 755278 SGTC_1950 st077106 7.18 µM -0.21622390936974 0.417236520250684 no 1985 0.414406608679396 2880 13831864 SGTC_2657 nystatin 74.44 µM -0.216548567425792 0.417107009246446 no 1986 0.414280085888928 2838 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_747 3448-8087 38.7 µM -0.21683674592335 0.416992058023803 no 1987 0.414167787032208 2860 5168703 SGTC_119 0121-0043 24.815 µM -0.216892835779539 0.416969685223789 no 1988 0.414145930468444 2779 1092378 SGTC_2754 granisetron 64.02 µM -0.218529339529308 0.416317044657764 no 1989 0.413508350514625 2928 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_177 1327-0068 8.361 µM -0.218867182658048 0.416182340889414 no 1990 0.413376755561353 2789 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_44 0929-0055 61.211 µM -0.221013729674257 0.415326706923501 no 1991 0.412540871289208 2806 1379590 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.221064729884884 0.415306382622328 no 1992 0.412521016166222 2972 6728940 SGTC_3192 9110362 49.47 µM -0.22179700528325 0.41501458559045 no 1993 0.412235955420207 2740 16649480 SGTC_2485 5633444 17.78 µM -0.223505190851523 0.41433409044647 no 1994 0.411571171796061 2905 5724239 SGTC_1000 4048-0884 8.67 µM -0.224159198991199 0.414073619151663 no 1995 0.411316715061073 2929 13040088 SGTC_2990 9074105 71.4286 µM -0.225237704847589 0.413644166092206 no 1996 0.410897179362763 2847 6502001 SGTC_2725 haloperidol 53.21 µM -0.225350694755404 0.413599180313809 no 1997 0.410853232500361 2813 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_737 1950-0117 57.9 µM -0.225791422551095 0.413423719884768 no 1998 0.410681824316974 2894 5393513 SGTC_614 0462-0418 107 µM -0.227119240215045 0.412895200145058 no 1999 0.410165511710826 2834 5188303 SGTC_865 0488-0499 301 µM -0.228029160275159 0.412533109945322 no 2000 0.409811785508047 2795 9634651 SGTC_1125 tnp00248 1.32998 µM -0.228371445701296 0.412396921404884 no 2001 0.409678742992704 2986 24207736 SGTC_1768 st044301 37.178 µM -0.228409631207859 0.412381728807499 no 2002 0.409663901358074 2853 3931349 SGTC_601 0986-0029 62.9 µM -0.229076995204358 0.412116230631781 no 2003 0.409404536622505 2832 24747981 SGTC_2669 eugenol 100 µM -0.229142732058977 0.412090080638309 no 2004 0.409378990755995 2869 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2963 9082507 9 µM -0.229172252174155 0.412078337720647 no 2005 0.409367519128757 2973 16459611 SGTC_91 0417-1751 58.384 µM -0.229313400105628 0.412022191042311 no 2006 0.40931266958717 2774 6795624 SGTC_2031 5180455 200 µM -0.229762159829478 0.411843692653927 no 2007 0.409138295089653 2809 29949 SGTC_1704 st028805 70.8 µM -0.22977726197332 0.411837685951634 no 2008 0.409132427164432 2863 2876101 SGTC_2569 tetrandrine 100 µM -0.230418805839669 0.411582538426697 no 2009 0.408883174659026 2889 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_271 rotenone 740 µM -0.230439864037724 0.411574164032955 no 2010 0.40887499375576 2957 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2946 9065502 71.43 µM -0.233166194745876 0.410490302317374 no 2011 0.407816177553528 2825 16489101 SGTC_2179 6298986 200 µM -0.233371647169656 0.410408651614426 no 2012 0.407736413833641 2954 738374 SGTC_3279 9140807 49.47 µM -0.233621808081015 0.410309238150672 no 2013 0.407639297899741 2788 45595718 SGTC_2701 st077767 14.721 µM -0.233804391064829 0.410236683662872 no 2014 0.407568420236741 2855 5721188 SGTC_2983 9022671 12.99 µM -0.234693738372511 0.409883320453146 no 2015 0.407223224035368 3021 6405161 SGTC_1511 0906-3109 28.5 µM -0.236369895318065 0.409217534330645 no 2016 0.406572827222834 2792 2882180 SGTC_2438 5259590 200 µM -0.236588495526417 0.409130723421633 no 2017 0.406488023046666 2936 1201127 SGTC_607 4491-0986 66.8 µM -0.237489022039896 0.408773151747294 no 2018 0.406138717386649 2963 698981 YDR232W HEM1 SGTC_593 1203-0218 61.7 µM -0.237761361346048 0.408665029034255 no 2019 0.406033094261444 2963 3666956 SGTC_634 1611-4317 11.2 µM -0.238378314878368 0.408420115123545 no 2020 0.405793842465537 2815 2843522 SGTC_1788 fluconazole 20 µM -0.238431495082014 0.408399005690175 no 2021 0.405773221068403 2928 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3178 9107506 49.47 µM -0.239193707932388 0.408096480961347 no 2022 0.405477690711405 2967 8897194 SGTC_2773 thioridazine 9.09 µM -0.240330771262983 0.407645278731972 no 2023 0.405036920956148 2805 5452 An antipsychotic. SGTC_1842 st055362 61.2 µM -0.241930112469816 0.407010845758642 no 2024 0.404417158357613 2843 676032 SGTC_695 3505-6186 243 µM -0.242438581871782 0.406809195134525 no 2025 0.404220170937737 2956 1819379 SGTC_1539 benzyladenosine 56 µM -0.245111163036377 0.405749700663689 no 2026 0.403185179839034 2828 92208 A nucleotide analog. SGTC_2329 6138490 200 µM -0.246572965366392 0.405170488085807 no 2027 0.402619364567892 3089 720019 SGTC_1720 st037298 9.481 µM -0.247060506686224 0.404977354821522 no 2028 0.402430698757234 2935 597396 SGTC_1151 3909-8316 15.3 µM -0.247143914999083 0.404944316001087 no 2029 0.402398424184634 2952 800431 SGTC_3195 9113082 49.47 µM -0.248496764120598 0.404408534465332 no 2030 0.401875036718503 2895 17018038 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.24915997086647 0.404145943874247 no 2031 0.401618520870872 2987 61125 An anti-inflammatory. SGTC_3348 9149464 3.537 µM -0.249645103126957 0.403953887572837 no 2032 0.401430907707627 2806 1951442 SGTC_2003 4023581 200 µM -0.24997382556332 0.403823764638458 no 2033 0.401303795170328 3000 16641307 SGTC_734 2023-0417 80 µM -0.251865963927068 0.403074979638465 no 2034 0.400572334240421 2969 3935732 SGTC_2671 danthron 100 µM -0.252318730415903 0.402895856758043 no 2035 0.400397355812301 2912 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2327 6189656 200 µM -0.25269344869677 0.402747626616356 no 2036 0.400252555405217 2972 5349088 SGTC_2920 7982904 15.77 µM -0.25339112406514 0.402471679155681 no 2037 0.399982992937474 2952 6456808 SGTC_1482 3346-2049 8.48 µM -0.253858582590994 0.40228681519275 no 2038 0.399802406542602 2951 3826804 SGTC_1264 0783-0040 158 µM -0.254561996144346 0.402008680227761 no 2039 0.399530707497989 2807 2855798 SGTC_2426 5582046 32.21 µM -0.254833245385611 0.401901439502543 no 2040 0.399425948324233 3026 2251934 SGTC_287 k060-0039 29.6 µM -0.255069434520956 0.401808066107405 no 2041 0.39933473561192 2998 5861974 SGTC_3132 9126706 49.47 µM -0.256283306555618 0.401328270786026 no 2042 0.398866043177005 3071 850858 SGTC_1675 st018485 24.5 µM -0.256506950785724 0.401239889324912 no 2043 0.39877970699535 2931 3323024 SGTC_3238 9133470 49.47 µM -0.25668388871496 0.401169969202078 no 2044 0.398711404940646 3005 3534688 SGTC_99 0109-0120 622.8 µM -0.257545145978045 0.40082967354182 no 2045 0.398378984433287 3031 759414 SGTC_791 1348-1292 225 µM -0.257585259657855 0.400813825857164 no 2046 0.398363503502908 2923 5437054 SGTC_1814 st052110 31.539 µM -0.25925566548483 0.400154044971413 no 2047 0.39771899199575 2992 674163 SGTC_93 0109-0045 59.227 µM -0.259291695818801 0.40013981675595 no 2048 0.397705093074351 2822 88733 SGTC_368 fentichlor 4.58 µM -0.259293746384966 0.400139007000659 no 2049 0.397704302059833 2929 7329 A pesticide. SGTC_741 4582-0002 126 µM -0.259659099124911 0.39999473842703 no 2050 0.397563372420735 2847 2912688 SGTC_507 nimesulide 162 µM -0.260197071964965 0.399782331383026 no 2051 0.397355881366537 3057 4495 A COX2 inhibitor. SGTC_908 3448-7491 47.7 µM -0.261570539118828 0.399240181945315 no 2052 0.396826279883663 2854 1203031 SGTC_1027 k015-0025 8.67 µM -0.262035079177826 0.399056857709878 no 2053 0.396647198761677 2853 3598955 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.262445156487694 0.3988950449353 no 2054 0.396489131251219 2805 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3082 9117008 49.47 µM -0.263032098554615 0.398663473174845 no 2055 0.396262919439194 2902 41448529 SGTC_1872 amphotericin b 148 nM -0.263675480961344 0.39840967446237 no 2056 0.396014995224968 2999 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2010 4012422 159 µM -0.264723983404515 0.397996157856133 no 2057 0.395611050174329 2956 952393 SGTC_3171 9103192 49.47 µM -0.267673235433786 0.396833624434739 no 2058 0.394475426640575 2952 13018434 SGTC_2610 ononetin 44.17 µM -0.267937006986138 0.39672969569746 no 2059 0.394373903671503 2934 259632 SGTC_1260 0700-1617 7.75 µM -0.271539801365314 0.395310894523595 no 2060 0.392987946051969 3002 2853078 SGTC_1147 3809-1045 12.3 µM -0.271634427494659 0.395273648815492 no 2061 0.392951562553513 2900 325925 SGTC_1868 st057644 42.7 µM -0.271900398624111 0.39516896527632 no 2062 0.392849302361467 2864 688665 SGTC_774 k060-0086 136 µM -0.272205724270955 0.39504880152612 no 2063 0.392731920319561 3023 5911235 SGTC_2037 5169046 200 µM -0.272361297692392 0.394987577995819 no 2064 0.392672114074111 2994 5718022 SGTC_3166 9102297 49.47 µM -0.274461775411807 0.39416122165679 no 2065 0.391864887454815 2941 25237072 SGTC_1659 st012954 42.1 µM -0.274796449435646 0.394029600256865 no 2066 0.391736313034552 3024 24207262 SGTC_444 curcumin 90.4 µM -0.275169007559826 0.393883093943099 no 2067 0.391593198281882 3019 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2986 9022445 71.43 µM -0.275615130821719 0.39370767832683 no 2068 0.391421843466757 3094 6459286 SGTC_1610 st001799 48.1 µM -0.277907966082534 0.392806476758129 no 2069 0.390541504323701 2856 621897 SGTC_1193 1488-0126 41.5 µM -0.278462272159901 0.392588692132793 no 2070 0.390328761295897 2915 1384710 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.278979827317536 0.392385377152179 no 2071 0.390130152935183 2882 803109 SGTC_509 pifithrin 175 µM -0.279004421072867 0.392375716537817 no 2072 0.390120715957894 2973 4817 A p53 inhibitor. SGTC_2798 7813637 45.45 µM -0.279077108444645 0.392347164772409 no 2073 0.390092825147482 3032 956368 SGTC_929 2805-0021 398 µM -0.279222056988458 0.392290230383958 no 2074 0.390037208752565 2972 3098024 SGTC_1464 k208-0027 110 µM -0.281660670267447 0.391332713231262 no 2075 0.389101857258874 3096 X1464 SGTC_1412 3909-8563 178 µM -0.281664869767194 0.391331064871211 no 2076 0.38910024705642 2997 23767530 SGTC_581 0958-0271 211 µM -0.281984653958392 0.391205551015968 no 2077 0.388977638693963 2909 4591145 SGTC_2148 5546263 113.568 µM -0.282462499310654 0.39101801998255 no 2078 0.388794448754755 2885 792097 SGTC_2708 st078559 56 µM -0.283361181170292 0.390665399778696 no 2079 0.388449991166964 2988 17250902 SGTC_409 arachidonic acid 100 µM -0.283473107300906 0.390621489063875 no 2080 0.388407096910583 2929 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_656 4090-1979 187 µM -0.283772022772142 0.390504225771239 no 2081 0.388292548055699 3039 22330961 SGTC_954 1189-0853 2.85 µM -0.283887986476052 0.390458736374508 no 2082 0.388248111654723 2857 2828194 SGTC_214 4373-3496 70 µM -0.284847240434674 0.390082504779078 no 2083 0.387880589053139 2946 3779166 SGTC_3204 9114183 49.47 µM -0.285276344791553 0.389914237898145 no 2084 0.387716217161526 2858 17027248 SGTC_1835 st008666 49.2 µM -0.285787625911112 0.389713773557946 no 2085 0.387520393067946 2909 690455 SGTC_572 0960-0087 17.7 µM -0.289692663413983 0.388183648341728 no 2086 0.38602568476063 2946 6796365 SGTC_2617 dihydrotanshinone i 20.83 µM -0.289852687852289 0.388120982203069 no 2087 0.385964469047501 2922 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_66 0109-0187 42.4 µM -0.291359303064828 0.387531129358791 no 2088 0.38538826820172 2825 759417 SGTC_1320 1313-0481 95.3 µM -0.292659453913272 0.38702231763144 no 2089 0.384891232311213 3088 6813365 YLR208W SEC13 SGTC_1988 st071872 53.4 µM -0.293430100882914 0.386720817861289 no 2090 0.384596710163192 3053 16414116 SGTC_771 0250-0039 27.3 µM -0.29487140230031 0.386157121937152 no 2091 0.38404605939047 2940 3005115 SGTC_2882 9058044 58.44 µM -0.295065606338399 0.386081186681051 no 2092 0.383971881390846 3011 18076804 SGTC_3017 9080681 49.47 µM -0.295173619897671 0.386038954446148 no 2093 0.383930626468247 2990 16451914 SGTC_1087 pterostilbene 9.05 µM -0.295976826512343 0.385724950981963 no 2094 0.38362388935556 3058 5281727 Similar to reservatol, lowers cholesterol. SGTC_3304 9125678 46.087 µM -0.296163714391126 0.385651900259641 no 2095 0.383552529067764 2937 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1510 1123-0200 71.5 µM -0.296317779293384 0.385591682429984 no 2096 0.383493704703182 3116 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1617 st002906 78 µM -0.296971805826344 0.385336080242687 no 2097 0.383244017160982 2906 5150859 SGTC_945 3381-0768 11.3 µM -0.297458083339308 0.385146068854715 no 2098 0.383058402544205 3084 1126236 YIL048W NEO1 SGTC_580 1123-0028 41 µM -0.297779990953527 0.385020299645586 no 2099 0.382935543525422 2913 1677248 YPR107C YTH1 SGTC_1444 4112-3581 28 µM -0.298264288127858 0.384831107674112 no 2100 0.382750729218447 2941 2877249 SGTC_281 1672-3440 14.9 µM -0.298418884384399 0.384770720009019 no 2101 0.382691738829179 3023 6833000 SGTC_1763 st044482 94.5 µM -0.298978756267038 0.384552048881193 no 2102 0.382478127330411 3072 88505 SGTC_45 0kpi-0036 14.9 µM -0.299224279162292 0.384456165722341 no 2103 0.382384462684349 3064 2795021 SGTC_195 4234-0266 16.654 µM -0.300128141512137 0.384103244615135 no 2104 0.382039707139158 2971 2303354 SGTC_1881 5652484 16 µM -0.30052074576591 0.38394997869863 no 2105 0.381889987242636 3084 2255129 SGTC_846 0335-0850 148 µM -0.301193229531254 0.383687494836561 no 2106 0.381633576157831 3019 6819598 SGTC_553 k007-0256 45.7 µM -0.302311966828453 0.383250947575997 no 2107 0.381207128335944 2994 6287000 SGTC_2198 6589944 200 µM -0.303355511338397 0.382843875195299 no 2108 0.380809472988511 2971 5290268 SGTC_1451 4152-0210 104 µM -0.303407588197967 0.382823564113203 no 2109 0.380789631760804 3107 659563 SGTC_2506 ethyl hematommate 54.16 µM -0.30355265152109 0.382766988033053 no 2110 0.380734364443166 3006 3940691 An allergen. SGTC_676 falcarinol 140 µM -0.303719807803934 0.382701798589766 no 2111 0.380670683001152 3134 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.304015237417335 0.382586591831841 no 2112 0.380558141242431 2950 2724278 An inhibitor of dopamine biosynthesis. SGTC_1020 4335-0961 93.3 µM -0.30544056669471 0.382030911632409 no 2113 0.380015314615944 2900 669075 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.306070560746326 0.381785378913343 no 2114 0.379775461049601 3169 804 An inhibitor of viral and cellular DNA polymerases. SGTC_740 k014-0057 261 µM -0.306635364183679 0.381565293884493 no 2115 0.379560466396597 3051 4012779 SGTC_1372 2752-0194 270 µM -0.308248097550722 0.380937076530539 no 2116 0.378946778233357 2911 823334 SGTC_2813 7971799 71.43 µM -0.308545900437577 0.38082110591491 no 2117 0.378833489590539 3053 2234054 SGTC_1138 3761-0006 1.03 µM -0.311396512013566 0.379711561822259 no 2118 0.377749602599552 2950 12061087 SGTC_838 0109-0203 71.4 µM -0.311791648755245 0.379557840564756 no 2119 0.377599435614 2940 759422 SGTC_153 4077-0274 519.67 µM -0.312099467016618 0.379438102272272 no 2120 0.377482465788944 3264 3121976 SGTC_2496 diffractaic acid 79.83 µM -0.312446470466915 0.379303135189205 no 2121 0.377350619207891 3208 94870 An apoptosis inducer which activates caspases. SGTC_2532 xanthone 78.9 µM -0.312587032702704 0.379248467655735 no 2122 0.377297215592048 3059 7020 An insecticide. SGTC_796 1234-0020 70.7 µM -0.313216124743932 0.379003830471596 no 2123 0.377058234286744 2949 46495034 SGTC_401 neomycin 50 µM -0.313249548729739 0.378990834126203 no 2124 0.377045538402802 3006 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_390 dec-rvkr-cmk 16.7 µM -0.313998419679878 0.378699684355715 no 2125 0.376761119512745 3005 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_901 1112-0062 60.1 µM -0.314570770800173 0.378477209237255 no 2126 0.376543787390487 2968 1908457 SGTC_1700 st030840 7.9285 µM -0.316930223050623 0.377560506883843 no 2127 0.375648274296281 3066 5499307 SGTC_2786 7743617 45.45 µM -0.317164544047116 0.377469505242426 no 2128 0.375559375918183 2999 583674 SGTC_2020 4017018 200 µM -0.317203886426258 0.377454226778745 no 2129 0.37554445057219 3078 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1873 rapamycin 2 nM -0.31736451997573 0.377391847339517 no 2130 0.375483512842773 2975 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_996 3970-0799 1.8 µM -0.319208552013696 0.376675976843197 no 2131 0.374784186182579 3027 6615648 YGL040C HEM2 SGTC_2002 4023503 131 µM -0.31977519175469 0.376456087011159 no 2132 0.374569377528455 3109 4736863 YCR052W RSC6 SGTC_947 3447-0010 211 µM -0.319898598351042 0.376408203244689 no 2133 0.374522600220547 2986 748350 SGTC_2100 5377183 190 µM -0.322844009138495 0.375265901932148 no 2134 0.37340669081929 3050 2844202 SGTC_2378 9074213 121.43 µM -0.324254417989629 0.374719297725939 no 2135 0.372872713026013 2987 657714 SGTC_3063 1327-0034 4 µM -0.325049077157282 0.374411438165189 no 2136 0.372571964225223 3064 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1359 1582-0056 520 nM -0.325086051210836 0.37439711596424 no 2137 0.372557972817355 3082 3661189 SGTC_1794 st048918 76.9 µM -0.325725609268948 0.374149405381346 no 2138 0.372315983307381 3056 672303 SGTC_3200 9114385 49.47 µM -0.326219269072957 0.373958238936755 no 2139 0.372129231768132 3111 17018030 YLR208W SEC13 SGTC_1666 st014829 29 µM -0.327047305855533 0.373637656872488 no 2140 0.371816052939199 2931 3858230 SGTC_1225 1216-0074 20.6 µM -0.32711746591151 0.373610497774949 no 2141 0.371789521002417 2999 4241466 SGTC_1727 st034309 9.9045 µM -0.327132019378443 0.373604864177486 no 2142 0.371784017496049 3223 870305 SGTC_1245 0418-0076 17.2 µM -0.327274553638315 0.373549691078901 no 2143 0.371730118445557 3160 6790114 SGTC_1153 4055-0057 267 µM -0.327525248782539 0.373452656642598 no 2144 0.371635324669575 2967 882706 SGTC_1968 st069590 43.6 µM -0.328093281687657 0.373232822673694 no 2145 0.371420566769779 3112 6384066 SGTC_1826 st055655 41.6 µM -0.328572597676544 0.373047355061556 no 2146 0.371239381470039 3054 676168 SGTC_429 1112-0049 25.5 µM -0.331842711181892 0.371782796967386 no 2147 0.370004015550016 2954 2836170 SGTC_913 3487-1245 167 µM -0.332754619275098 0.371430406516948 no 2148 0.369659758215034 2930 4016153 SGTC_2523 spermine 47.74 µM -0.332775729671243 0.371422250059538 no 2149 0.369651789997957 3098 1103 A DNA binding polyamine. SGTC_336 4111-0029 111 µM -0.332786477826458 0.371418097299856 no 2150 0.369647733078354 3010 3131175 SGTC_2575 plumbagin 510 nM -0.333646946743324 0.371085686930025 no 2151 0.36932299392873 2936 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1927 st060202 13.8 µM -0.335909772960158 0.370211987162142 no 2152 0.368469453549179 3050 688887 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.336193159704764 0.370102615777052 no 2153 0.368362605393237 3062 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2930 9013230 14.89 µM -0.336669467492618 0.369918811358905 no 2154 0.368183041211501 3129 2995857 SGTC_1938 st074717 56.4 µM -0.337550123443785 0.369579049602005 no 2155 0.367851116901863 2931 17250979 SGTC_3100 9120536 49.47 µM -0.33844298999585 0.369234680867696 no 2156 0.367514691063659 3024 16421196 SGTC_517 1365-0151 113 µM -0.338721672331229 0.369127217649144 no 2157 0.367409706322562 3164 768657 SGTC_2793 7325131 81.82 µM -0.339597918469695 0.36878939340294 no 2158 0.367079672947292 3042 4176441 SGTC_3183 9108214 49.47 µM -0.340607314573288 0.368400360721885 no 2159 0.366699611079994 3085 4974831 SGTC_1745 st081495 74 µM -0.340946707232053 0.36826958522877 no 2160 0.366571850927244 3028 13842402 YBL026W LSM2 SGTC_1316 1272-0050 65.9 µM -0.342385122015413 0.367715501785899 no 2161 0.36603054179027 3009 7340392 SGTC_1179 1021-1431 9.29 µM -0.342415873872905 0.367703659041328 no 2162 0.36601897205321 3092 2840958 SGTC_2651 TUB2.036 5 µM -0.342997933569624 0.367479527719863 no 2163 0.365800007368986 3170 15992207 YFL037W TUB2 SGTC_1061 3448-9325 110 µM -0.343895939001583 0.367133825035766 no 2164 0.365462273013699 3056 723482 SGTC_26 0302-0163 425.158 µM -0.345201272313506 0.366631506559995 no 2165 0.36497153116066 3023 3100915 SGTC_1450 4112-4260 37.6 µM -0.346054719527377 0.366303206324524 no 2166 0.364650795987163 3155 1633175 SGTC_1486 3970-0793 4.53 µM -0.347410979008138 0.365781687868739 no 2167 0.36414129317471 3098 2844330 SGTC_1673 st016611 27.3 µM -0.347653769057708 0.365688354666125 no 2168 0.364050110111859 3208 5226799 SGTC_949 1165-0505 146 µM -0.348716786658285 0.365279803764033 no 2169 0.363650970257671 3020 6244267 SGTC_452 diindolylmethane 8 µM -0.34949472331401 0.364980915206444 no 2170 0.363358965781339 3132 3071 Inhibits expression of several cancer promoting factors. SGTC_1638 st008370 60.6 µM -0.349739637029092 0.364886834657403 no 2171 0.363267051966436 3027 24207134 SGTC_953 1188-0045 9.7 µM -0.349754414496215 0.36488115833787 no 2172 0.363261506373734 3126 6144426 SGTC_1905 st060207 84.5 µM -0.349877038839592 0.36483405702712 no 2173 0.363215489805617 2988 1948547 SGTC_2922 7999257 32.47 µM -0.350438918864617 0.364618259048353 no 2174 0.363004661412738 3045 2988377 SGTC_2441 5730946 39.09 µM -0.351739803614569 0.364118800554564 no 2175 0.362516703370061 3159 1774275 SGTC_1342 1486-1464 234 µM -0.352202636870751 0.363941157089294 no 2176 0.362343149777867 3028 3253938 SGTC_1805 st050013 60.3 µM -0.352638807124783 0.363773774106032 no 2177 0.362179620190699 3063 4037144 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.353036579916206 0.363621149043324 no 2178 0.362030508562426 2996 16486 A toxic proline analog. SGTC_780 0109-0199 192 µM -0.353373300632658 0.363491966519308 no 2179 0.361904299665033 3197 610414 SGTC_2818 7996756 12.99 µM -0.355642664046635 0.362621733266562 no 2180 0.361054094270277 2953 2241621 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.357032932149322 0.362088956881883 no 2181 0.360533576009562 3108 688801 SGTC_2270 7924575 90.91 µM -0.357852821501733 0.361774885289788 no 2182 0.360226729353134 3173 1262135 SGTC_135 0933-0004 26.348 µM -0.358941438649892 0.361358017133155 no 2183 0.359819449450431 3150 21230617 YGL099W LSG1 SGTC_1066 ketoconazole 628 nM -0.359242755169305 0.36124266194885 no 2184 0.359706747224901 3187 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_435 c-PAF 6.7 µM -0.359309242884557 0.36121720967416 no 2185 0.359681880289078 3177 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_216 k038-0035 28.382 µM -0.361398753453649 0.360417634165424 no 2186 0.358900689860622 3123 4444231 YPR107C YTH1 SGTC_1411 3909-8223 150 µM -0.361638699562273 0.360325854980386 no 2187 0.358811020608855 3140 X1411 SGTC_1962 st076595 64.5 µM -0.363443368419469 0.35963582888717 no 2188 0.358136855032098 3046 279619 SGTC_826 1683-5028 118 µM -0.363895612760979 0.359462982096129 no 2189 0.35796798044985 3116 722377 SGTC_3276 9139060 49.47 µM -0.36443795281791 0.359255738836105 no 2190 0.357765499471243 3007 4870619 SGTC_2353 9059630 146.67 µM -0.364842519379663 0.359101169629128 no 2191 0.357614481856172 3142 4779114 SGTC_3224 9130643 49.47 µM -0.365176680619688 0.358973516957329 no 2192 0.357489762122446 3227 17644395 SGTC_3325 9138760 55.175 µM -0.366171361029121 0.358593633124259 no 2193 0.357118605485563 3061 43844959 SGTC_1679 SEC14.276 6.7 µM -0.366327027326242 0.358534194405751 no 2194 0.357060532137995 3163 1005053 YMR079W SEC14 SGTC_2390 9097792 176.6 µM -0.366741720944218 0.358375866920819 no 2195 0.356905841426377 3060 4497149 SGTC_1330 1469-0054 61.8 µM -0.367337535697746 0.358148431115655 no 2196 0.356683629352827 3185 7102664 SGTC_693 4161-2696 114 µM -0.367341874641836 0.358146775028231 no 2197 0.356682011300338 3160 805759 SGTC_327 1273-0057 3.96 µM -0.367839977531644 0.357956676950899 no 2198 0.3564962789659 3077 3108138 SGTC_619 1652-1634 108 µM -0.367887337700133 0.357938604050122 no 2199 0.356478621102906 3071 5400454 SGTC_1012 4112-3522 18 µM -0.367943706760384 0.357917093721715 no 2200 0.356457604747114 3213 3112398 SGTC_427 1354-0053 47.3 µM -0.371245330112918 0.356657989491669 no 2201 0.355227406548927 3251 6813657 SGTC_1569 carminic acid 40.6 µM -0.371472561852869 0.356571389828945 no 2202 0.355142794378974 3228 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2363 9053361 176 µM -0.371661457953986 0.356499405783588 no 2203 0.355072462330363 3219 6469797 YMR079W SEC14 SGTC_1693 xanthone 101.9 µM -0.372135829523626 0.356318656015345 no 2204 0.354895860425415 3076 7020 An insecticide. SGTC_705 1124-0212 310 µM -0.372806922143398 0.356063004771179 no 2205 0.354646075275602 3225 9554485 SGTC_2056 5235370 200 µM -0.372934572710467 0.356014383891079 no 2206 0.35459856995321 3065 5511916 SGTC_1946 st076057 65.1 µM -0.373110684187199 0.355947308557673 no 2207 0.354533033553433 3024 953009 SGTC_261 5-fluorouridine 15.376 µM -0.373270817433187 0.355886322700925 no 2208 0.354473446873757 3280 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_575 k072-0246 11.9 µM -0.373848509285276 0.355666342628395 no 2209 0.354258513381396 3096 6796779 SGTC_2850 9015429 58.44 µM -0.375472394374052 0.355048238835189 no 2210 0.353654586637682 3122 6457570 SGTC_1860 st056228 74.6 µM -0.375553904359367 0.355017223503547 no 2211 0.353624282570443 3166 688679 SGTC_497 capsazepine 133 µM -0.375965813259886 0.354860502911565 no 2212 0.353471155831954 3080 2733484 A calcium channel blocker. SGTC_975 1335-0046 28.5 µM -0.376130430473927 0.35479787722241 no 2213 0.353409966171117 3084 16486740 SGTC_1332 1480-0653 17.5 µM -0.378113306323977 0.354043836113033 no 2214 0.352673211918389 3208 5749438 SGTC_1934 st074720 32.6 µM -0.378419030474534 0.353927627223669 no 2215 0.352559666599455 3037 17250992 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.37847197593491 0.353907503492372 no 2216 0.352540004098804 3150 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_3341 9147222 25.867 µM -0.37853613306301 0.353883118930583 no 2217 0.352516178418388 3197 1939759 SGTC_2616 abietic acid 100 µM -0.380120917848363 0.353280971317102 no 2218 0.351927829478498 3233 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2800 7887935 81.82 µM -0.380310703332538 0.353208885872953 no 2219 0.351857395637908 3208 2961002 SGTC_1741 st038134 10.228 µM -0.380319970281741 0.353205366180382 no 2220 0.351853956586052 3301 1272587 SGTC_849 0386-0493 241 µM -0.380374358136286 0.353184709308547 no 2221 0.35183377298691 3057 726119 SGTC_260 nsc-65238 3.989 µM -0.380524832074811 0.353127560551924 no 2222 0.351777933547341 3187 3246252 SGTC_835 0312-0010 67.2 µM -0.380785324325985 0.353028635581715 no 2223 0.351681274922952 3041 1626196 SGTC_2753 fluvastatin 17.09 µM -0.385064410688356 0.351405028778309 no 2224 0.350094847461345 3144 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_931 2812-0076 566 µM -0.390342517184055 0.349406096787401 no 2225 0.348141643839154 3055 3450959 SGTC_1776 st049249 45.9 µM -0.390626001525651 0.349298852692886 no 2226 0.348036851635685 3138 1822314 SGTC_2319 6033012 152.6 µM -0.394590229957139 0.347800421462528 no 2227 0.346572662515024 3080 847246 SGTC_1892 st058411 7.36 µM -0.395232203059524 0.347557986020227 no 2228 0.346335764336093 3213 3934738 SGTC_3181 9108277 49.47 µM -0.397623233513644 0.346655583730239 no 2229 0.345453965897282 3096 17097298 SGTC_3190 9110366 49.47 µM -0.399705257413322 0.345870511893458 no 2230 0.344686809680665 3201 17123768 SGTC_1130 3454-2858 15.9 µM -0.400266384392597 0.345659040052646 no 2231 0.344480162199551 3142 715628 YIL048W NEO1 SGTC_1548 st061468 90.8 µM -0.400332770092064 0.3456340244681 no 2232 0.34445571725923 3204 390799 SGTC_2694 st077685 81.9 µM -0.402616561348598 0.344773853046881 no 2233 0.343615162161948 3053 2838096 SGTC_2558 carylophyllene oxide 100 µM -0.403700925302601 0.344365716614343 no 2234 0.343216329547512 3157 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1658 st012944 20 µM -0.406161879439391 0.343440127423919 no 2235 0.342311830773208 3179 24207260 SGTC_2763 lisinopril 49.32 µM -0.406645730997799 0.343258256246025 no 2236 0.342134102186227 3187 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_957 1187-1561 14.1 µM -0.407159540476984 0.343065164155004 no 2237 0.341945407722333 3218 1538454 SGTC_2294 7971431 200 µM -0.408567375358274 0.342536303052752 no 2238 0.341428588391915 3219 5741572 SGTC_2719 novobiocin 32.65 µM -0.409292866497101 0.342263888620727 no 2239 0.341162374954057 3239 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_3117 9124945 49.47 µM -0.410907580884169 0.341657874773201 no 2240 0.340570151719268 3070 17592065 SGTC_1904 st060225 78 µM -0.410976805808902 0.341631903271793 no 2241 0.340544771103973 3209 66595 SGTC_3097 9117246 49.47 µM -0.411232848975067 0.341535848643532 no 2242 0.340450901753859 3160 16423892 SGTC_1361 1608-0041 5.61 µM -0.4113616211263 0.341487543631665 no 2243 0.340403695643943 3124 X1361 SGTC_418 lividomycin a 100 µM -0.411997988514263 0.341248867616881 no 2244 0.340170448785147 3258 72394 An antibiotic. SGTC_2629 bisabolol 100 µM -0.41237813294693 0.341106320895253 no 2245 0.340031144139584 3276 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_639 0833-0042 114 µM -0.412532994497395 0.341048257343898 no 2246 0.339974401090549 3143 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3022 9087993 49.47 µM -0.41454204952026 0.340295326961046 no 2247 0.339238589246813 3220 17173644 SGTC_825 1988-2224 89.6 µM -0.41514917480194 0.340067920625624 no 2248 0.339016351402812 3132 1180859 SGTC_2099 5377090 177.372 µM -0.416682357287914 0.339493907116067 no 2249 0.338455380333787 3226 2243829 SGTC_3085 9117376 49.47 µM -0.41758165027263 0.33915739076694 no 2250 0.338126507626901 3237 16480349 SGTC_2511 berberine 10.47 µM -0.417921012738075 0.339030434307734 no 2251 0.338002434375149 3121 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1183 1254-0324 198 µM -0.418496508035942 0.338815181672908 no 2252 0.337792069561917 3253 5799357 SGTC_1553 gossypol 38.6 µM -0.41849802229726 0.338814615362797 no 2253 0.337791516110205 3138 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1073 triclabendazole 3.09 µM -0.418577454658447 0.338784909409679 no 2254 0.337762484640491 3230 50248 An antihelmetic and likely tubulin inhibitor. SGTC_529 4076-0302 30.3 µM -0.419588971024879 0.338406712312349 no 2255 0.337392873345685 3144 5816522 SGTC_2372 9071633 200 µM -0.420024819861103 0.338243802463981 no 2256 0.337233661126702 3275 21321366 SGTC_1293 1000-1278 195 µM -0.42180760554952 0.337577755401406 no 2257 0.336582726939467 3266 678847 SGTC_650 1328-0195 38 µM -0.422361856752286 0.337370791183801 no 2258 0.33638045728815 3244 2780821 SGTC_2168 5727979 200 µM -0.4225745609926 0.337291377862701 no 2259 0.336302845103841 3178 695210 SGTC_374 0880-0231 82.3 µM -0.423563349542055 0.336922307973721 no 2260 0.335942144497368 3192 6833587 SGTC_2365 9042475 200 µM -0.424521241013724 0.336564920222433 no 2261 0.335592858876101 3245 6464479 SGTC_1392 3455-1037 33.9 µM -0.424998848435108 0.336386780784956 no 2262 0.335418757106313 3294 981132 SGTC_2125 5246583 200 µM -0.42532657761703 0.336264564621443 no 2263 0.335299310746431 3315 835267 SGTC_1430 4049-0248 69.1 µM -0.427474412528117 0.335464026753274 no 2264 0.33451690910703 3250 22774488 SGTC_648 0375-0473 33.3 µM -0.427615988814795 0.335411284830929 no 2265 0.334465361658351 3162 1713139 SGTC_2220 6782180 200 µM -0.427787289296891 0.335347473983848 no 2266 0.334402995902554 3201 833803 SGTC_1626 st003712 1.76 µM -0.427971233230871 0.33527895863517 no 2267 0.33433603210495 3282 24207035 SGTC_3036 9090181 49.47 µM -0.428180846837297 0.335200888538558 no 2268 0.334259729827706 3168 25236586 SGTC_3055 9094636 49.47 µM -0.428318583948782 0.335149592549164 no 2269 0.334209595325598 3334 25236176 SGTC_1205 4161-2785 76 µM -0.428330678527073 0.335145088438893 no 2270 0.334205193198969 3238 3498106 SGTC_3180 9109287 49.47 µM -0.428726879337372 0.334997553441488 no 2271 0.334060998540203 3256 18891271 SGTC_1453 4237-0541 195 µM -0.429781540810477 0.334604948748093 no 2272 0.333677280905273 3282 739892 SGTC_2978 9011784 42.97 µM -0.430067109802301 0.334498674888932 no 2273 0.333573412199842 3224 2994934 SGTC_1597 7-benzyloxygramine 47.5 µM -0.431061045042148 0.334128887560637 no 2274 0.333211992179101 3184 260807 SGTC_1889 st059080 5.18 µM -0.431139133588085 0.334099842025274 no 2275 0.333183603762091 3312 176925 Isolated from Daphnopsis sellowiana. SGTC_1636 st007707 68.9 µM -0.431223830052907 0.334068339755363 no 2276 0.333152814173669 3343 403051 SGTC_2942 9052777 62.25 µM -0.431330304972941 0.334028738796825 no 2277 0.333114109089058 3192 6469503 SGTC_187 1488-2104 32.728 µM -0.433639657479227 0.333170282261201 no 2278 0.332275065951519 3236 2852859 SGTC_1778 st046819 58.9 µM -0.433887597528835 0.333078167245088 no 2279 0.332185033245553 3171 671715 SGTC_2982 9019404 25.97 µM -0.434300006863585 0.332924970689732 no 2280 0.332035299433167 3142 22333232 SGTC_2357 9067248 200 µM -0.434427282692048 0.332877697518988 no 2281 0.331989094702543 3251 9150235 SGTC_808 0711-0032 135 µM -0.435067173356249 0.332640067667404 no 2282 0.331756834988786 3257 4252555 SGTC_1011 4112-3381 17.4 µM -0.435775875677372 0.332376962374588 no 2283 0.331499674315141 3322 2877139 SGTC_2163 5671233 125 µM -0.435806980812403 0.332365416503493 no 2284 0.331488389282515 3365 701023 SGTC_1102 cgs 12066b 26.1 µM -0.437750274923776 0.331644403709802 no 2285 0.330783660261035 3210 6438352 A 5-HT1B full agonist. SGTC_3027 9089541 49.47 µM -0.439525553081376 0.330986273864963 no 2286 0.330140385368116 3262 9943819 SGTC_1327 1436-0082 2.18 µM -0.439666401384399 0.330934081003958 no 2287 0.330089370220502 3187 15992205 SGTC_3293 9120939 62.045 µM -0.439727631664463 0.33091139248651 no 2288 0.330067193645029 3288 934087 SGTC_2761 levamisole 97.89 µM -0.440018795896637 0.330803511804827 no 2289 0.329961747038922 3319 26879 An alkaline phosphatase inhibitor. SGTC_902 1120-0002 2.07 µM -0.440362998592254 0.330675997706458 no 2290 0.329837109708311 3209 3280475 SGTC_2938 9059746 27.26 µM -0.440485574435852 0.330630592729812 no 2291 0.329792729009652 3263 6471769 SGTC_251 melphalan 456.522 µM -0.440891417400567 0.330480276736599 no 2292 0.329645803667035 3237 460612 A DNA alkylator. SGTC_595 3909-8003 73.7 µM -0.441305180845905 0.33032705530708 no 2293 0.329496037973648 3294 699517 SGTC_3218 9131285 49.47 µM -0.441322838496778 0.330320517105675 no 2294 0.329489647223817 3359 17156417 SGTC_1418 3966-3099 2.4 µM -0.442698314067353 0.329811371060859 no 2295 0.328991981035142 3280 740335 SGTC_1111 tnp00062 510.699 nM -0.443170360399136 0.329636710982504 no 2296 0.328821257893942 3332 676306 SGTC_2283 7944793 200 µM -0.443522811681422 0.329506326038387 no 2297 0.328693811508301 3235 2970533 SGTC_894 0960-0238 55.9 µM -0.443655061220092 0.329457407321745 no 2298 0.328645995213523 3298 6741907 YDL195W SEC31 SGTC_2845 9003024 42.97 µM -0.445052845649875 0.328940549538801 no 2299 0.328140782328277 3380 2990173 SGTC_2472 5377652 49.4 µM -0.445125086641465 0.328913845913528 no 2300 0.328114680195984 3223 1610903 SGTC_432 NS 1619 61.3 µM -0.445277291487961 0.328857586792298 no 2301 0.328059688251833 3315 4552 A K+/calcium channel activator. SGTC_76 0433-0009 400.328 µM -0.446199117313559 0.328516937365196 no 2302 0.327726710238633 3249 2841569 SGTC_628 1636-0253 16 µM -0.446297384676785 0.328480632265457 no 2303 0.327691222591218 3238 4456143 SGTC_2965 9082772 38.63 µM -0.447252403156979 0.328127882911815 no 2304 0.327346414424204 3363 16459634 SGTC_2072 5231554 129 µM -0.447661645186375 0.327976770557198 no 2305 0.32719870318124 3320 789545 SGTC_926 2268-1401 59.4 µM -0.448809825712583 0.327552956018766 no 2306 0.326784425033389 3268 2931578 SGTC_2832 7992762 51.95 µM -0.449703539026534 0.32722322369775 no 2307 0.326462109590362 3075 2985177 SGTC_1181 1222-0449 220 µM -0.450245545253233 0.327023318086142 no 2308 0.326266699495173 3345 658318 SGTC_2860 9025725 38.96 µM -0.451629643299072 0.326513052968263 no 2309 0.325767905576271 3140 40546248 SGTC_1194 1488-0194 225 µM -0.454000049210817 0.325639927042684 no 2310 0.324914395687396 3158 1391452 SGTC_1336 1486-0901 104 µM -0.454195323582101 0.325568041352554 no 2311 0.324844124299706 3252 5006114 SGTC_1753 st043925 64 µM -0.455612457024399 0.325046551345075 no 2312 0.324334341866374 3286 670181 SGTC_2276 7947513 42.08 µM -0.455644806341298 0.325034651136475 no 2313 0.324322708752839 3244 2105100 SGTC_1972 st070201 17.4 µM -0.457320685956385 0.324418396660782 no 2314 0.323720281705278 3317 2829099 SGTC_516 3992-2719 87.3 µM -0.457491880198321 0.324355472135381 no 2315 0.323658768612583 3115 5350887 YDR037W KRS1 SGTC_1006 4099-6547 255 µM -0.457894872406353 0.324207367250394 no 2316 0.323513985467047 3325 3146833 SGTC_1637 st007924 17.4 µM -0.459249704293524 0.32370965292278 no 2317 0.323027430542934 3211 683336 SGTC_2293 7624732 200 µM -0.461064794152325 0.323043351089257 no 2318 0.322376059612185 3226 894453 SGTC_2111 5486399 200 µM -0.461152387887986 0.323011210616994 no 2319 0.322344639117253 3246 689674 SGTC_1345 1488-0192 31.4 µM -0.461569311818907 0.322858248251701 no 2320 0.322195102943344 3326 658348 SGTC_3074 9116018 49.47 µM -0.461642051870679 0.322831564221374 no 2321 0.322169016553532 3180 17027303 SGTC_1216 1165-0504 9.65 µM -0.462384097684629 0.322559403557081 no 2322 0.321902950554878 3335 6304004 SGTC_772 k072-0172 35.3 µM -0.462967046521426 0.322345661659127 no 2323 0.321693993962764 3215 5861980 SGTC_2122 5258151 111.688 µM -0.463800173700013 0.322040292220239 no 2324 0.321395459444593 3217 2173356 SGTC_56 0957-0365 83.25 µM -0.464925287214508 0.321628090514954 no 2325 0.320992480520103 3305 6752360 SGTC_955 1216-0110 33 µM -0.465789109890836 0.3213117654246 no 2326 0.320683230432879 3253 3619719 SGTC_1953 st076800 12.1 µM -0.466372471519085 0.32109821625309 no 2327 0.320474456274331 3230 297591 SGTC_1623 st003709 20.3 µM -0.467255587460337 0.320775049625513 no 2328 0.320158513763875 3214 16192618 SGTC_3163 9099914 49.47 µM -0.467621506417506 0.320641185350299 no 2329 0.32002764121435 3292 16268368 SGTC_1144 3486-0183 12.5 µM -0.470438799873478 0.319611315923704 no 2330 0.319020774522748 3256 6744069 SGTC_2829 7992743 58.44 µM -0.470976105885802 0.319415059754956 no 2331 0.318828899067323 3309 16462845 SGTC_303 1348-1668 34.2 µM -0.472191609629372 0.318971272058628 no 2332 0.318395014022607 3274 5380509 SGTC_2164 5685496 200 µM -0.472508940758139 0.318855455235636 no 2333 0.318281780770266 3354 759046 SGTC_1497 4476-2978 41.3 µM -0.473340421717592 0.31855207228111 no 2334 0.317985164000917 3315 1528379 SGTC_659 k018-0002 107 µM -0.474013314281026 0.318306642584913 no 2335 0.31774520640042 3346 6797879 YHR007C ERG11 SGTC_1335 1486-0900 202 µM -0.474256960160468 0.318217795254897 no 2336 0.317658339657133 3272 X1335 SGTC_2540 epiandrosterone 100 µM -0.474663356202163 0.318069623106067 no 2337 0.317513470148481 3331 441302 A steroid. SGTC_115 0527-0192 112.043 µM -0.475182749127166 0.317880294635512 no 2338 0.317328360900063 3339 4233931 SGTC_586 0957-0265 8.15 µM -0.475288333231185 0.317841813067513 no 2339 0.317290736796905 3289 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1366 1683-0113 21.9 µM -0.475751770620439 0.31767293025657 no 2340 0.317125616696008 3232 708623 SGTC_1681 tripelennamine 100 µM -0.479955274937491 0.316142852632125 no 2341 0.315629597901464 3338 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_770 0389-1121 67.2 µM -0.481112840573966 0.315722049054433 no 2342 0.315218151227117 3416 6753108 SGTC_1326 1431-2094 10.8 µM -0.481590351458131 0.3155485316345 no 2343 0.31504849083701 3186 616278 SGTC_1634 st006576 41 µM -0.481936036795375 0.315422942217076 no 2344 0.314925692618702 3400 3915356 SGTC_2264 7948757 110.76 µM -0.482990083095138 0.315040132963467 no 2345 0.314551388812027 3172 2971411 SGTC_403 arphamenine a 50 µM -0.483660445617386 0.314796773523342 no 2346 0.314313434559029 3283 5487158 An arginine aminopeptidase inhibitor. SGTC_2951 9072950 58.06 µM -0.483875348833554 0.314718774950243 no 2347 0.314237168077331 3347 16488155 SGTC_722 3534-0461 190 µM -0.484112889518912 0.314632569783464 no 2348 0.314152877066447 3300 658262 SGTC_2017 5132927 60.65 µM -0.486126194802424 0.313902333374612 no 2349 0.313438847820157 3224 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.486146411319852 0.31389500442593 no 2350 0.313431681465001 3292 16623 A steroid. SGTC_3316 9136639 10.545 µM -0.486738479000133 0.313680398958183 no 2351 0.3132218364399 3345 4903665 SGTC_1228 0124-0032 52.5 µM -0.487572973360291 0.313378028667767 no 2352 0.312926171433403 3350 X1228 SGTC_721 1187-1332 279 µM -0.487773138434958 0.313305519587813 no 2353 0.312855269949684 3245 25730 SGTC_2567 aureobasidin a 60 nM -0.488214873863703 0.313145528052291 no 2354 0.312698825106062 3411 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1030 k029-0042 36.7 µM -0.489108430559793 0.312821999556813 no 2355 0.312382466587519 3294 6080581 SGTC_1852 st056254 31.4 µM -0.489509270968892 0.312676914789633 no 2356 0.312240596288676 3222 442583 SGTC_1967 st070177 51.4 µM -0.48957974346944 0.312651410164804 no 2357 0.312215656683106 3403 5729214 SGTC_1660 st012960 28.1 µM -0.489747818136697 0.312590586068886 no 2358 0.312156179992255 3321 24207266 SGTC_344 k064-0035 6.43 µM -0.494241306494076 0.310966346116807 no 2359 0.310567885456442 3237 5088750 SGTC_711 k292-0785 179 µM -0.495740088735506 0.310425404245561 no 2360 0.310038899587306 3290 4146315 SGTC_694 1315-0438 43.2 µM -0.496523174476214 0.310142935115013 no 2361 0.309762670556765 3268 6793154 SGTC_1148 3909-7663 27.7 µM -0.498382468039855 0.309472712779722 no 2362 0.30910724574448 3398 4084526 SGTC_510 ag-490 170 µM -0.498950385287796 0.309268120942401 no 2363 0.308907168588507 3423 5328779 SGTC_1022 4477-0945 21.3 µM -0.499497344135091 0.309071135244085 no 2364 0.308714528660189 3308 4648966 SGTC_2244 6635614 200 µM -0.502588329894311 0.307958958202098 no 2365 0.307626867939343 3130 836499 SGTC_3080 9117754 49.47 µM -0.502712992174964 0.307914139976014 no 2366 0.307583036956025 3463 9550191 SGTC_610 4215-0184 155 µM -0.504730859552985 0.307189080996044 no 2367 0.306873941657472 3355 5605015 SGTC_382 3229-0966 23.2 µM -0.50550154585697 0.306912357016251 no 2368 0.306603306486588 3426 5722370 SGTC_29 0299-0004 12.984 µM -0.505589358781989 0.306880833729414 no 2369 0.306572476677053 3298 16871 A napthoquinone isolated from Swertia calycina. SGTC_32 0928-0142 34.1 µM -0.506706995733375 0.306479746633945 no 2370 0.306180210626501 3363 2244242 SGTC_3223 9129970 49.47 µM -0.507180849084449 0.306309764492435 no 2371 0.306013965514515 3304 17248386 SGTC_2256 7954252 200 µM -0.508601578199531 0.305800366072434 no 2372 0.305515761260239 3335 2972920 SGTC_536 3852-0578 10.6 µM -0.509192430741879 0.305588628054326 no 2373 0.305308674081823 3416 2869208 SGTC_110 0850-0284 111.64 µM -0.510930987116285 0.304965975895823 no 2374 0.304699691127243 3278 3906265 SGTC_1455 4262-0120 131 µM -0.511387949082961 0.304802411644801 no 2375 0.304539715796101 3471 1529587 SGTC_2189 6047310 154.431 µM -0.511553982073303 0.30474299171496 no 2376 0.304481599465767 3313 711535 SGTC_3169 9102970 49.47 µM -0.512300104660401 0.304476032763235 no 2377 0.304220496009386 3406 17027839 SGTC_3289 9119912 71.43 µM -0.513945302588289 0.303887757203231 no 2378 0.303645116461631 3422 17014829 SGTC_1351 1496-0003 46.5 µM -0.51499072400002 0.303514208119657 no 2379 0.303279751001648 3412 3891978 SGTC_1300 1094-0077 113 µM -0.515784251816614 0.303230802429069 no 2380 0.303002551377591 3318 5532636 SGTC_1901 st060216 58.6 µM -0.516010798920933 0.303149913637431 no 2381 0.30292343347116 3311 688792 SGTC_1509 1326-1131 80 µM -0.51634068321592 0.303032145494684 no 2382 0.302808243264 3374 768313 SGTC_1865 st057639 52.2 µM -0.516457443805069 0.302990467064652 no 2383 0.302767477073984 3353 688818 SGTC_3102 9121669 49.47 µM -0.516916867242171 0.302826497876521 no 2384 0.302607096278763 3320 41905072 SGTC_1806 st050005 60.3 µM -0.517383147987864 0.30266012194002 no 2385 0.302444360596036 3321 5194765 SGTC_1167 k781-0610 148 µM -0.517600465145412 0.302582593926072 no 2386 0.302368528591843 3323 4525169 SGTC_2883 9059145 45.46 µM -0.518254892701184 0.302349180317618 no 2387 0.30214022008688 3273 16476510 SGTC_3210 9128157 49.47 µM -0.518267522363491 0.302344676511062 no 2388 0.302135814769415 3306 17590849 SGTC_1097 itavastatin 7.23 µM -0.519112177783419 0.302043536112108 no 2389 0.301841258332268 3365 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2139 5578692 56.4705 µM -0.520046191171199 0.301710694321204 no 2390 0.301515690462975 3365 650991 YMR113W FOL3 SGTC_1107 amlodipine 47 µM -0.520113769244197 0.301686618830985 no 2391 0.301492140990024 3348 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2223 6903751 107.57 µM -0.522144273859382 0.300963630807615 no 2392 0.300784941186739 3373 5598863 SGTC_1084 voriconazole 435 nM -0.522588880958406 0.300805426882327 no 2393 0.300630189933683 3412 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2116 5511452 16.8835 µM -0.5236983797579 0.300410799192887 no 2394 0.300244171369944 3413 870744 SGTC_2826 7992541 19.48 µM -0.524008894981036 0.300300396719581 no 2395 0.30013617657023 3421 2985066 SGTC_1467 k284-1082 293 µM -0.526191804554341 0.299524789912911 no 2396 0.299377473820279 3402 3334705 SGTC_1496 4469-0713 57.4 µM -0.526819314110248 0.299301998430475 no 2397 0.299159534581584 3425 746691 SGTC_1886 st057356 49.9 µM -0.528861421449414 0.298577487978657 no 2398 0.298450792857946 3288 24207747 SGTC_2338 7999974 200 µM -0.529588639669316 0.298319674107578 no 2399 0.298198586285948 3410 315925 SGTC_2016 5121758 140 µM -0.529972793273372 0.298183524645317 no 2400 0.298065397156801 3401 2795203 SGTC_2132 5317594 122.667 µM -0.53316862024054 0.297051977204238 no 2401 0.296958430714307 3321 794577 SGTC_97 0535-0701 19.132 µM -0.533202216988908 0.297040092030432 no 2402 0.296946803511655 3402 2832013 YGL099W LSG1 SGTC_2595 hexamethylquercetagetin 100 µM -0.533594549369877 0.296901316768162 no 2403 0.296811040074868 3329 386331 SGTC_369 0957-0393 4.5 µM -0.535393502931422 0.296265373654732 no 2404 0.296188890922614 3371 6997992 SGTC_156 3474-0145 5.642 µM -0.536566296736215 0.295851119237206 no 2405 0.295783614950309 3420 2265471 SGTC_163 TUB2.036 7.546 µM -0.538143678661166 0.295294376076797 no 2406 0.29523892978806 3404 15992207 YJR013W GPI14 SGTC_1271 0832-2808 169 µM -0.539809188266185 0.294707051785934 no 2407 0.294664314925841 3452 3663794 SGTC_3035 9091303 49.47 µM -0.542146602446611 0.293883697290363 no 2408 0.293858758452064 3445 25237002 SGTC_991 3996-0057 64.7 µM -0.546177780537742 0.292466219547593 no 2409 0.292471869037216 3393 715343 SGTC_2583 asiatic acid 100 µM -0.546595908947786 0.292319375709534 no 2410 0.292328190164886 3485 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_745 0469-0705 296 µM -0.547974212596987 0.291835567866851 no 2411 0.291854804826944 3549 3486736 SGTC_2987 9018338 71.43 µM -0.548302928001864 0.291720238326075 no 2412 0.291741958623166 3495 5055682 SGTC_2459 5811157 9.22 µM -0.549169308119237 0.291416371357184 no 2413 0.291444632519623 3434 2870684 YBR192W RIM2 SGTC_2897 9048598 12.99 µM -0.549471259577522 0.291310502121465 no 2414 0.291341041427028 3349 6467404 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.550018290229233 0.291118749748506 no 2415 0.291153414298174 3360 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.55281574362488 0.290139072341645 no 2416 0.290194793428625 3374 688667 SGTC_1648 st011736 69.8 µM -0.55629070317725 0.288924285964142 no 2417 0.289006070788509 3497 2855514 SGTC_2546 rhodinyl acetate 100 µM -0.557390969516297 0.288540151169672 no 2418 0.28863016703746 3459 6708682 SGTC_3172 9105863 49.47 µM -0.558696562822032 0.288084643235118 no 2419 0.288184412760239 3411 2348785 SGTC_343 4130-2827 29.8 µM -0.558791048735161 0.288051691254517 no 2420 0.288152166086364 3399 1118244 SGTC_2193 5925765 200 µM -0.559915510683215 0.287659671557982 no 2421 0.287768534256348 3462 877370 SGTC_277 nystatin 15.5 µM -0.560818844308764 0.287344926291504 no 2422 0.2874605194959 3348 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3007 9078383 71.4286 µM -0.56137598395873 0.287150885406697 no 2423 0.287270626215846 3372 6496995 SGTC_2642 cholecalciferol 100 µM -0.56153009669833 0.287097221897227 no 2424 0.287218109520912 3436 9821465 A vitamin D precursor, similar to steriods. SGTC_2048 5246248 200 µM -0.56204411172731 0.286918271356618 no 2425 0.287042982492312 3485 677046 SGTC_1042 0350-0096 82 µM -0.563137751918544 0.286537704527851 no 2426 0.286670543148002 3394 3122515 SGTC_1391 3442-0225 151 µM -0.563199902541482 0.286516084438298 no 2427 0.286649384626256 3402 5227075 SGTC_1844 rapamycin 4 nM -0.565090734994138 0.285858698328816 no 2428 0.286006025003285 3442 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2145 5634607 200 µM -0.56513635451973 0.285842846643299 no 2429 0.285990511347954 3402 308662 SGTC_2962 9082311 13.18 µM -0.567535177053934 0.285009903074318 no 2430 0.285175317048287 3375 16459453 SGTC_1234 0326-0494 15.5 µM -0.568541275195372 0.284660900282045 no 2431 0.284833743635638 3521 1547813 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.568703015332106 0.284604813704251 no 2432 0.284778850580128 3443 688788 SGTC_2429 5902844 64.44 µM -0.569460956152095 0.284342053123184 no 2433 0.284521679998602 3443 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2067 5224629 34.075 µM -0.571458144652706 0.283650229778219 no 2434 0.283844562357396 3493 2835000 SGTC_548 1436-0017 110 µM -0.571472757684792 0.283645170816804 no 2435 0.283839610865992 3536 9677137 SGTC_3318 9139014 38.6185 µM -0.571583105718467 0.283606970253901 no 2436 0.283802221785675 3453 16643984 SGTC_2914 7968218 45.32 µM -0.572650405767756 0.283237616875383 no 2437 0.283440711655483 3436 2977111 SGTC_1646 st011709 75.6 µM -0.573020079655905 0.283109740129862 no 2438 0.283315549193545 3474 5757843 SGTC_832 4083-0019 164 µM -0.573109923687422 0.283078665673458 no 2439 0.283285134224125 3516 1990758 SGTC_2876 9059903 25.97 µM -0.573450864323489 0.282960759045942 no 2440 0.283169729575865 3474 6916095 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.573746415686684 0.282858568356999 no 2441 0.283069706951494 3388 6708630 An antioxidant. SGTC_1424 4048-1941 275 µM -0.575004278155954 0.282423844574987 no 2442 0.282644201819334 3519 X1424 SGTC_1508 1080-0625 72.9 µM -0.576667617715466 0.281849479703785 no 2443 0.282082005836201 3438 767111 SGTC_2606 farnesol 9.78 µM -0.57736994226421 0.281607130366213 no 2444 0.28184478731797 3519 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_161 4065-0411 162.148 µM -0.578234653681232 0.281308884712996 no 2445 0.28155285279883 3434 1906281 YLR208W SEC13 SGTC_2346 9031566 143.75 µM -0.579081704801978 0.281016878152379 no 2446 0.28126702204935 3402 4771086 SGTC_2412 st077135 33.4 µM -0.579232041050477 0.280965067579003 no 2447 0.281216306905238 3583 13258915 SGTC_1992 st073643 23.3 µM -0.579586935565293 0.280842778144011 no 2448 0.281096602622639 3471 3161292 SGTC_1616 st002734 56.1 µM -0.580122763242376 0.280658191590618 no 2449 0.280915917069123 3398 4026101 SGTC_3268 9137683 49.47 µM -0.581387977164993 0.280222572802254 no 2450 0.280489499311162 3460 1953228 SGTC_366 0181-0206 4.31 µM -0.582001225734185 0.280011546513211 no 2451 0.280282927624775 3548 274874 SGTC_354 2783-3500 4.88 µM -0.582383364466368 0.279880086901569 no 2452 0.280154242150342 3415 6740761 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.583654467196328 0.279443030127565 no 2453 0.279726403564629 3520 5357218 A potent inhibitor of glutathione S-transferases. SGTC_332 4112-0506 40.9 µM -0.583713118168071 0.279422871543074 no 2454 0.279706669975313 3467 2790355 SGTC_3084 9116877 49.47 µM -0.584312134150422 0.279217027697935 no 2455 0.279505164941522 3437 27241325 SGTC_714 4296-0578 26.1 µM -0.584623138251136 0.279110184365155 no 2456 0.279400573016195 3484 1589775 SGTC_1403 3909-7815 62.9 µM -0.585531131761804 0.278798363185433 no 2457 0.279095319983218 3430 6615483 SGTC_2404 5161160 200 µM -0.58621247425734 0.278564489411684 no 2458 0.278866369974007 3478 2831543 SGTC_2961 9083290 32.55 µM -0.586660657198047 0.278410700788068 no 2459 0.278715817899049 3496 17741490 SGTC_2525 harmine 47.85 µM -0.58763058111064 0.278078024703791 no 2460 0.278390139926184 3419 5280953 A monoamine oxidase inhibitor SGTC_457 grayanotoxin iii 135 µM -0.588081260225763 0.277923511414615 no 2461 0.278238875456542 3482 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1203 3992-3522 103 µM -0.590880184576124 0.276964852225528 no 2462 0.277300351901298 3671 5322312 SGTC_3092 9117248 49.47 µM -0.593076626426421 0.276213684681774 no 2463 0.276564936060368 3521 17141857 SGTC_2476 5806916 10.51 µM -0.593117329886503 0.276199773828038 no 2464 0.276551316697 3433 2870194 SGTC_3255 9139072 49.47 µM -0.594279780579502 0.275802638750498 no 2465 0.276162499942297 3519 17646060 SGTC_3081 9117243 49.47 µM -0.59538983099729 0.27542366759441 no 2466 0.275791460665182 3552 45595589 SGTC_2689 tacrolimus 100 µM -0.598237216572815 0.274452743296647 no 2467 0.274840831001851 3482 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2318 6029776 164 µM -0.5989231779824 0.274219091422675 no 2468 0.274612057211605 3554 818325 SGTC_823 0417-1665 178 µM -0.599413722862486 0.274052062508656 no 2469 0.274448514070117 3507 3429856 SGTC_590 k048-0076 22.4 µM -0.599828151483605 0.27391099011724 no 2470 0.274310384855755 3520 6832814 SGTC_2787 5284540 71.43 µM -0.600222456851526 0.273776801059645 no 2471 0.274178994601545 3477 736958 SGTC_81 0411-0046 9.971 µM -0.601328818700462 0.273400460326625 no 2472 0.273810499267944 3446 12925265 SGTC_1966 st070145 16.1 µM -0.601349455915181 0.273393442793191 no 2473 0.273803627969617 3463 3748532 SGTC_3088 9117578 49.47 µM -0.602182507149416 0.273110244321111 no 2474 0.273526329219287 3564 678341 SGTC_1252 0493-0875 34.8 µM -0.606000536333326 0.271814155983664 no 2475 0.272257198533414 3504 3960963 SGTC_3302 9125395 16.351 µM -0.60662868473805 0.271601214976642 no 2476 0.272048679733478 3446 17599668 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.606670809894718 0.271586937608492 no 2477 0.272034698798468 3488 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_212 3807-4682 38.772 µM -0.608055200053399 0.271117937970732 no 2478 0.271575431904459 3570 3125501 YBL034C STU1 SGTC_1956 st077085 54 µM -0.609312137275739 0.270692466578226 no 2479 0.271158781802308 3498 24208685 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.609440920056228 0.270648892635037 no 2480 0.271116110837733 3648 5282309 SGTC_1199 1638-0010 4.46 µM -0.611295182541664 0.27002188734514 no 2481 0.270502089848555 3475 3111136 SGTC_666 0272-0154 136 µM -0.611384698107026 0.269991636712969 no 2482 0.270472465229808 3514 6870312 SGTC_2238 6671620 73.2395 µM -0.612955406338168 0.269461112216821 no 2483 0.269952913066881 3520 729941 SGTC_2582 agaric acid 100 µM -0.61397395992022 0.269117363714511 no 2484 0.269616267440208 3518 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_449 xestospongin c 11.1929 µM -0.61434674755983 0.268991607791935 no 2485 0.269493108721461 3514 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_3010 9080089 71.4286 µM -0.614352666326065 0.268989611397371 no 2486 0.26949115355232 3550 17027233 SGTC_1427 4048-4900 550 nM -0.615127201566438 0.268728425539431 no 2487 0.269235359658569 3544 24132586 SGTC_600 1495-0418 41.6 µM -0.615655558722017 0.268550328057192 no 2488 0.269060937131825 3532 5377768 SGTC_1038 k292-0204 154 µM -0.615771921524108 0.268511112710122 no 2489 0.269022530786987 3495 4454212 SGTC_291 SEC14.278 35.5 µM -0.615911761373605 0.268463989188469 no 2490 0.268976379321509 3554 1068044 SGTC_1436 4092-1007 8.32 µM -0.616197056592173 0.268367862712533 no 2491 0.268882235423084 3513 2881121 SGTC_937 3122-0005 46.7 µM -0.617517710443689 0.267923111398583 no 2492 0.268446651648919 3545 759535 SGTC_1909 st060837 51.5 µM -0.61769100265508 0.267864780034839 no 2493 0.268389522004527 3481 678937 SGTC_2474 5321570 43.32 µM -0.61818868558941 0.267697292071422 no 2494 0.268225483721915 3521 2841384 SGTC_777 1315-0167 517 µM -0.620720967953216 0.266845907485879 no 2495 0.267391615438719 3522 4221767 SGTC_1442 4112-3290 3 µM -0.621142116604536 0.266704444915546 no 2496 0.267253060164958 3541 704353 SGTC_246 cycloheximide 667 µM -0.622065907991307 0.266394278984788 no 2497 0.266949265525456 3442 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_147 4466-0538 29.23 µM -0.622093997003209 0.266384850868438 no 2498 0.266940031009506 3636 6742687 YHR072W ERG7 SGTC_1446 4239-0190 62 µM -0.62271920836285 0.266175041506441 no 2499 0.26673452891312 3520 1340085 SGTC_3250 9135583 49.47 µM -0.622936985263716 0.266101979260532 no 2500 0.266662966126798 3558 7699353 SGTC_105 0111-0055 734.78 µM -0.623748284516413 0.265829884875967 no 2501 0.266396453823684 3512 5179370 SGTC_1258 0671-0043 57.1 µM -0.624197429489713 0.265679310833151 no 2502 0.26624896740209 3516 4298767 SGTC_227 fluconazole 33.516 µM -0.62563914284701 0.265196274618321 no 2503 0.265775829213847 3528 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_989 1501-0895 10.3 µM -0.626984766915759 0.264745835168054 no 2504 0.265334610251894 3553 2830112 SGTC_924 2046-0044 21.3 µM -0.627163802526067 0.264685933425976 no 2505 0.26527593399792 3572 3623589 SGTC_2732 terfenadine 20 µM -0.628437778555394 0.264259885596914 no 2506 0.264858597631732 3546 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.629414643685685 0.263933435417266 no 2507 0.26453881677099 3422 4000243 SGTC_1963 st076565 50.3 µM -0.629533728404017 0.263893653577756 no 2508 0.264499847330977 3572 4914280 SGTC_1150 3909-7983 10.9 µM -0.630614475930324 0.263532755248568 no 2509 0.264146315691425 3529 23965914 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.631247144527518 0.263321602646159 no 2510 0.263939470353334 3516 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_834 0312-0008 75.7 µM -0.632068989834878 0.263047441541905 no 2511 0.263670898717162 3580 6385573 YIL048W NEO1 SGTC_2924 9010168 62.78 µM -0.632112899640908 0.26303279768377 no 2512 0.263656553312581 3576 2993929 SGTC_2587 piperic acid 92.2 µM -0.632725243725656 0.26282862522736 no 2513 0.263456541011351 3499 5370536 SGTC_2246 7293507 91.5585 µM -0.633237617026033 0.262657848097962 no 2514 0.263289242087368 3565 887656 SGTC_654 1124-0271 80.9 µM -0.634416880574631 0.262265008232804 no 2515 0.262904397973699 3552 5403748 SGTC_1101 ebselen 5.29 µM -0.634638604235411 0.262191180599886 no 2516 0.262832072198226 3630 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2339 9000433 200 µM -0.635137412157822 0.26202513077059 no 2517 0.262669399342208 3497 2988954 SGTC_3011 9081274 71.4286 µM -0.635178539133671 0.262011442280727 no 2518 0.262655989178667 3544 6625322 SGTC_1874 staurosporine 7.6 µM -0.635808979909864 0.261801655524941 no 2519 0.262450466884142 3576 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_200 k038-0079 37.545 µM -0.636331673239574 0.261627788383826 no 2520 0.262280132468725 3518 3436683 SGTC_2537 larixol 68.93 µM -0.63681798373501 0.261466076752989 no 2521 0.262121705296862 3587 6708759 SGTC_213 1246-0773 967 nM -0.637505292549585 0.261237615203133 no 2522 0.261897881822224 3526 6251622 SGTC_70 0141-0289 43.283 µM -0.638682358057972 0.26084659683505 no 2523 0.261514795889891 3605 352408 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.639326582959848 0.260632714404926 no 2524 0.261305249322882 3570 4330530 SGTC_503 tyrphostin 8 294 µM -0.640142865269208 0.260361838690066 no 2525 0.261039861708184 3567 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_3209 9113616 49.47 µM -0.641119216228591 0.260038036250861 no 2526 0.26072261507644 3615 16649353 SGTC_855 0428-0020 25 µM -0.641740977376005 0.259831940213732 no 2527 0.260520689098502 3556 6812414 SGTC_1387 3342-1166 1.8 µM -0.643184804722574 0.259353678024627 no 2528 0.260052095962157 3554 3418228 SGTC_2188 6126565 140.678 µM -0.643246435012943 0.259333273357037 no 2529 0.260032103570654 3542 874518 SGTC_1791 st048313 56.1 µM -0.643806014065071 0.259148044879146 no 2530 0.25985061670841 3542 1204976 SGTC_962 1254-0300 21.5 µM -0.644660576059281 0.258865304966217 no 2531 0.259573584928101 3546 7340576 SGTC_2088 5278280 127.392 µM -0.645049424545736 0.258736703625072 no 2532 0.259447578584695 3617 791502 SGTC_1514 1189-1591 158 µM -0.645111914503332 0.258716039810679 no 2533 0.259427331662392 3612 767698 YMR146C TIF34 SGTC_3305 9127027 53.8275 µM -0.647363374657401 0.257972110338417 no 2534 0.258698397045492 3534 41905295 SGTC_2128 5255449 168.493 µM -0.647940842616838 0.257781481822965 no 2535 0.258511606522477 3586 736008 SGTC_2098 5376439 882.5 nM -0.650855540721708 0.256820424975634 no 2536 0.257569871649505 3642 2844116 SGTC_1785 bathophenanthroline 24 µM -0.652303716582195 0.256343615602716 no 2537 0.25710263147094 3557 72812 An iron chelator. SGTC_952 1185-0122 232 µM -0.652789294000806 0.25618384343349 no 2538 0.256946063266369 3564 678600 SGTC_3077 9117319 49.47 µM -0.653154466602989 0.256063722930203 no 2539 0.256828350738231 3605 17154678 SGTC_1843 st055809 45.5 µM -0.655256785251854 0.255372754458699 no 2540 0.256151219576293 3598 16413835 SGTC_2751 anetholtrithion 17.25 µM -0.658379222973282 0.254348305071434 no 2541 0.255147241375907 3584 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1057 3448-5381 134 µM -0.658466575998344 0.254319676178631 no 2542 0.25511918379732 3623 5497911 SGTC_182 3448-4371 550.524 µM -0.659415908605026 0.254008652917355 no 2543 0.254814364576098 3637 3491403 SGTC_877 0771-0151 33.1 µM -0.659444367013915 0.253999332368064 no 2544 0.254805229869255 3602 6166523 SGTC_2332 7982454 138.89 µM -0.659905151486602 0.253848443625442 no 2545 0.254657349078669 3599 2981748 SGTC_2036 5160441 105 µM -0.660226544717797 0.2537432278779 no 2546 0.254554230106097 3623 134534 YIL048W NEO1 SGTC_149 3970-0822 46.1 µM -0.661263158593789 0.253404023674212 no 2547 0.25422178180792 3663 3114250 YBL034C STU1 SGTC_1115 galangin 695.678 nM -0.663747064388596 0.252592202577412 no 2548 0.25342610560032 3654 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2470 5664817 21.68 µM -0.664649723185892 0.252297524134986 no 2549 0.253137279054031 3650 2859561 SGTC_1876 myriocin 605 nM -0.664871140156277 0.252225268913498 no 2550 0.253066458029195 3649 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2856 9022925 19.48 µM -0.666027331490686 0.251848145170509 no 2551 0.252696815410751 3615 4944862 SGTC_2347 9049783 174.81 µM -0.666493052479257 0.251696321546365 no 2552 0.252548001462255 3618 6467988 YPL169C MEX67 SGTC_535 2293-4129 48.2 µM -0.667492757759318 0.251370583979666 no 2553 0.252228717078254 3640 396118 YIL048W NEO1 SGTC_248 streptozotocin 5.23457 mM -0.668663424978118 0.250989424713349 no 2554 0.251855101872997 3653 5300 DNA alkylating agent. SGTC_36 0335-0881 14.2 µM -0.670295922573077 0.250458408461392 no 2555 0.25133458293239 3586 23828853 SGTC_1740 st038286 13.222 µM -0.671068487661947 0.250207317411507 no 2556 0.251088450334719 3645 716786 SGTC_479 n-linoleoylglycine 10 µM -0.672206521306316 0.24983768888225 no 2557 0.250726114990891 3624 6433346 An anti-infammatory. SGTC_2971 9092186 9.93 µM -0.672358946160478 0.249788203954677 no 2558 0.250677605903745 3583 25236400 SGTC_1627 st003713 25.6 µM -0.672770666233885 0.249654564513387 no 2559 0.250546601172541 3668 16195070 YER133W GLC7 SGTC_234 nsc-17383 10.7 µM -0.673152163730962 0.249530768866114 no 2560 0.250425245312621 3659 408974 SGTC_1554 st069299 38.7 µM -0.673199839567117 0.249515300386627 no 2561 0.250410081631146 3624 24207999 SGTC_2594 a-mangostin 100 µM -0.674329313651888 0.249148990294125 no 2562 0.250050985733533 3651 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2486 5283202 22.39 µM -0.674490759476595 0.249096653693917 no 2563 0.249999679274407 3608 1377751 SGTC_1419 3993-2473 62.6 µM -0.674591369482826 0.24906404146565 no 2564 0.249967708878044 3666 704026 SGTC_611 3453-1652 23.7 µM -0.675578446692019 0.248744205846478 no 2565 0.249654164818614 3636 1560575 SGTC_1656 st012921 11 µM -0.675829277608578 0.248662965748558 no 2566 0.24957452193524 3580 6732821 SGTC_2957 9076800 11.52 µM -0.67670189679148 0.248380448569822 no 2567 0.249297556387677 3585 16459615 SGTC_719 2810-4230 27.3 µM -0.677558737507276 0.248103206356863 no 2568 0.249025757949412 3617 721079 SGTC_3134 9127454 49.47 µM -0.677760681462034 0.248037888749447 no 2569 0.24896172227555 3720 24262820 SGTC_23 0213-0011 39.996 µM -0.680147997250682 0.247266421032256 no 2570 0.24820537793143 3666 627608 SGTC_2905 7799065 20.05 µM -0.683787699201089 0.24609271463644 no 2571 0.247054617584587 3586 1296806 SGTC_415 dibenzyl ketone 100 µM -0.685186942767385 0.245642292603837 no 2572 0.246612981132546 3651 7593 SGTC_3267 9137951 49.47 µM -0.686004118043078 0.245379445585256 no 2573 0.246355255792608 3648 16643986 SGTC_3127 9126946 49.47 µM -0.686709824141982 0.245152574672763 no 2574 0.246132802452941 3601 27243249 SGTC_861 0443-0273 110 µM -0.687464333508117 0.244910139277612 no 2575 0.245895084519038 3668 6149169 SGTC_3249 9135183 49.47 µM -0.688440590771471 0.244596644452561 no 2576 0.245587684992165 3679 4902779 SGTC_1895 st058434 18.3 µM -0.688669419962506 0.244523194314247 no 2577 0.245515662151332 3665 5393175 SGTC_2607 solasodine 47.35 µM -0.688698643094116 0.244513815059561 no 2578 0.245506465134324 3685 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1691 st019933 84.6 µM -0.690207444575683 0.244029823967827 no 2579 0.245031871201082 3637 6176082 SGTC_308 4092-1169 104 µM -0.691554384443516 0.243598191564508 no 2580 0.244608608198169 3631 2268590 YDL196W YDL196W SGTC_1561 5-methoxyflavone 52.9 µM -0.691835766694093 0.243508073559236 no 2581 0.2445202362586 3626 94525 SGTC_1274 0865-0114 173 µM -0.694170692091906 0.242760964609906 no 2582 0.243787584989123 3672 870624 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.696231124124996 0.2421027175032 no 2583 0.243142049499598 3674 688669 SGTC_490 phenamil 164 µM -0.696397132548368 0.242049724881471 no 2584 0.243090079152188 3606 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2407 paclitaxel 400 µM -0.697004706202785 0.241855831019457 no 2585 0.242899924294044 3787 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3029 9088683 49.47 µM -0.698577916357131 0.24135416721224 no 2586 0.242407924374998 3679 25236615 SGTC_759 3486-0358 89.3 µM -0.69879874987017 0.241283793301964 no 2587 0.242338904959069 3688 875103 SGTC_1133 3473-0247 50 µM -0.699364497543576 0.241103555085155 no 2588 0.242162134495714 3674 711311 SGTC_1957 st077035 62.4 µM -0.70266419845785 0.24005378278853 no 2589 0.241132522003455 3732 705593 SGTC_1141 3253-0389 52.6 µM -0.70313821973175 0.239903181850661 no 2590 0.240984807909251 3649 5402031 SGTC_353 1988-1175 58.3 µM -0.703196020886988 0.239884821415275 no 2591 0.240966799330719 3555 2788357 SGTC_3248 9135562 49.47 µM -0.704849578604656 0.239359896441166 no 2592 0.240451925544035 3709 17650701 SGTC_312 4092-0653 6.84 µM -0.704855001097225 0.239358176093525 no 2593 0.24045023811062 3685 1148278 SGTC_1458 k015-0034 6.33 µM -0.70618920578219 0.238935089765954 no 2594 0.240035241081262 3688 3598957 SGTC_2024 5144227 134 µM -0.706279703228157 0.238906407163064 no 2595 0.240007106497929 3717 3475211 SGTC_2007 4011539 71.82 µM -0.70660353309071 0.238803786726913 no 2596 0.239906446362479 3689 45595301 SGTC_2735 sertaconazole 140 nM -0.706824178445721 0.238733878877771 no 2597 0.239837873565341 3742 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3060 1327-0027 12.5 µM -0.707253596859172 0.238597856827073 no 2598 0.239704448336817 3625 16000455 YPR107C YTH1 SGTC_831 k061-1017 217 µM -0.707898856775228 0.238393544866333 no 2599 0.23950403486211 3738 1240153 SGTC_2674 ligustilide 100 µM -0.708090689824478 0.238332822263111 no 2600 0.23944447042965 3668 5319022 A signalling regulator. SGTC_1558 st069300 45.6 µM -0.708325804957196 0.238258410756306 no 2601 0.239371477883716 3638 24208000 SGTC_2635 hydroquinidine 100 µM -0.709086477203112 0.238017753079195 no 2602 0.239135407066254 3661 442912 An experimental heart treatment. SGTC_3201 9113999 49.47 µM -0.709655396069637 0.23783784850701 no 2603 0.238958929152925 3694 16649224 SGTC_3244 9134489 49.47 µM -0.710275357117247 0.237641888220687 no 2604 0.2387666991301 3666 16584271 SGTC_1765 st044815 90.4 µM -0.710883930095524 0.237449613725872 no 2605 0.238578082492834 3698 645695 SGTC_805 3852-0218 479 µM -0.710999309341001 0.237413170070661 no 2606 0.23854233189604 3652 6615355 SGTC_2131 toluylene red 5.2905 µM -0.711782324122555 0.237165928401624 no 2607 0.238299789971284 3697 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2928 9011484 9.79 µM -0.715327032255217 0.236048436879881 no 2608 0.237203494333209 3707 2994751 SGTC_646 4092-0839 27.3 µM -0.715869085847988 0.235877807189806 no 2609 0.237036094351972 3741 877796 SGTC_218 alverine citrate 93.75 µM -0.716451812414031 0.23569445016554 no 2610 0.236856205957146 3710 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2614 arthonioic acid 13.39 µM -0.716793944382632 0.23558683373698 no 2611 0.236750624387599 3662 6710684 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.718098559089602 0.235176720544987 no 2612 0.236348259280607 3664 4620898 SGTC_1807 st050092 58.9 µM -0.720667059191866 0.234370451091847 no 2613 0.235557192087779 3700 5008496 SGTC_1145 3546-0597 10.2 µM -0.720685362826704 0.234364710952375 no 2614 0.235551560034767 3682 875334 SGTC_1987 st072290 61.9 µM -0.721270191499174 0.234181345821893 no 2615 0.23537164658167 3708 54697379 SGTC_2063 5246145 200 µM -0.721757816828125 0.234028518232046 no 2616 0.235221694231909 3727 711240 SGTC_854 0422-0053 192 µM -0.722291059367811 0.233861456919997 no 2617 0.235057774284434 3732 3596728 SGTC_2661 dactinomycin 12.96 µM -0.723834328472889 0.233378333643047 no 2618 0.234583725692657 3717 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_661 1304-0007 33.6 µM -0.724518876996819 0.233164211866896 no 2619 0.234373621174304 3724 3117130 SGTC_2051 5263410 176 µM -0.725184915985998 0.232955984454092 no 2620 0.234169297672034 3762 227584 SGTC_1819 st053448 58.6 µM -0.72525380101129 0.232934454446928 no 2621 0.234148171160504 3675 2857616 SGTC_220 paclitaxel 373.376 µM -0.726042379849196 0.23268806298168 no 2622 0.233906395260273 3667 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3107 9121808 49.47 µM -0.726093125509439 0.232672212462 no 2623 0.233890841531881 3656 662681 SGTC_3322 9139058 2.11 µM -0.726299204588584 0.232607849371691 no 2624 0.233827683438275 3801 4908926 YPR165W RHO1 SGTC_3046 9092212 49.47 µM -0.726762364509674 0.232463230331015 no 2625 0.233685770981132 3732 25236637 SGTC_3141 9094609 49.47 µM -0.727348976144973 0.232280135991539 no 2626 0.233506101404666 3679 25236309 YDL196W YDL196W SGTC_2114 5491910 81.25 µM -0.727608701782316 0.232199095566041 no 2627 0.233426576155741 3783 2849228 SGTC_83 0170-0301 39.027 µM -0.727950824994051 0.232092369204012 no 2628 0.233321844573979 3671 3089716 SGTC_2403 6032726 181.2 µM -0.732085781592522 0.230804618748442 no 2629 0.232058105804362 3749 2881040 SGTC_1780 st038448 24.544 µM -0.732648290713302 0.230629745282328 no 2630 0.231886484887711 3773 728868 YDL195W SEC31 SGTC_3050 9093513 49.47 µM -0.733468997993761 0.230374735737542 no 2631 0.231636214853592 3737 25236664 SGTC_2811 7967822 32.47 µM -0.734838025207483 0.229949703676105 no 2632 0.231219072956327 3774 2232244 SGTC_681 1642-0006 26.6 µM -0.73498160955037 0.22990515151957 no 2633 0.231175347176113 3740 4446530 SGTC_1760 st045453 10.4495 µM -0.735208044652152 0.229834901783638 no 2634 0.231106400207317 3766 3323419 YIL048W NEO1 SGTC_53 0973-0023 39.979 µM -0.735250712326101 0.229821665814166 no 2635 0.23109340966043 3687 674768 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.736240993258969 0.229514589987024 no 2636 0.230792024472262 3858 16725076 SGTC_1563 conessine 56.1 µM -0.737236377990435 0.229206163346331 no 2637 0.230489307334823 3805 441082 An anti-amoebic, histamine inhibitor. SGTC_637 1181-0519 7.26 µM -0.737715721910973 0.229057718368984 no 2638 0.230343608118129 3747 6252091 YGR060W ERG25 SGTC_3220 9131269 49.47 µM -0.738008219895977 0.228967163026484 no 2639 0.23025472705569 3774 17722206 SGTC_1695 st026914 34.495 µM -0.740617211493603 0.22816032663609 no 2640 0.229462784580373 3703 3289191 SGTC_1521 st012942 49.4 µM -0.74071071646629 0.228131439720973 no 2641 0.229434430114857 3788 24207259 SGTC_3140 9094243 49.47 µM -0.743382289091015 0.227306967949135 no 2642 0.228625131954765 3761 19291112 SGTC_539 4859-0462 2.54 µM -0.743599127999411 0.227240123222767 no 2643 0.228559515469162 3793 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_253 dyclonine 31.25 µM -0.744867062416136 0.226849480124065 no 2644 0.228176044315738 3810 3180 An oral anasthetic. SGTC_1127 asiatic acid 681.4 nM -0.745963770086077 0.226511896737508 no 2645 0.227844650542176 3733 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2588 indole-3-carbinol 100 µM -0.747086200741897 0.226166689305809 no 2646 0.227505764630235 3762 3712 Induces cell cycle arrest. SGTC_889 0919-1524 82.7 µM -0.747446569581701 0.226055919700917 no 2647 0.227397021771482 3791 3905452 SGTC_1104 tacrolimus 29.8 µM -0.748228155523228 0.225815782456131 no 2648 0.227161275475692 3782 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1594 piperine 70.1 µM -0.748395778063592 0.225764300306028 no 2649 0.227110734180206 3741 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1302 1159-0335 255 µM -0.750454473038656 0.225132552122451 no 2650 0.226490516859579 3774 649284 SGTC_1512 0259-0544 12.2 µM -0.751688691660012 0.224754290284169 no 2651 0.226119146242519 3734 18476 SGTC_2911 7942208 15.64 µM -0.753828300405074 0.224099400283256 no 2652 0.225476164088663 3756 1243384 SGTC_3038 9091290 49.47 µM -0.755083276810754 0.223715782812045 no 2653 0.225099508308207 3773 25236843 SGTC_1033 k072-0102 21.3 µM -0.75608656828707 0.223409368374152 no 2654 0.224798647263865 3729 5965931 SGTC_725 1497-0963 19 µM -0.756440790464036 0.223301242727793 no 2655 0.224692479722737 3789 3549977 SGTC_906 1165-0455 526 µM -0.75754492725005 0.222964398240649 no 2656 0.224361730163471 3738 3252859 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.757713496754237 0.222912997383912 no 2657 0.224311258674231 3817 279621 SGTC_632 0781-2353 4.65 µM -0.758203670950889 0.222763569956038 no 2658 0.224164531972215 3825 6811515 YHR007C ERG11 SGTC_2022 5136654 200 µM -0.761074952600804 0.221889419836028 no 2659 0.223306150028314 3802 1713771 SGTC_2299 7976368 114.88 µM -0.764093720841639 0.220972484192077 no 2660 0.22240569697207 3818 2979718 SGTC_3130 9127414 49.47 µM -0.764990067795849 0.220700641500087 no 2661 0.222138729489593 3782 1494646 SGTC_3135 9127742 49.47 µM -0.76564693060771 0.220501550857909 no 2662 0.221943206015664 3848 3643468 SGTC_1208 2323-2347 50.3 µM -0.766277668956578 0.220310475257829 no 2663 0.221755551337961 3765 5412760 SGTC_980 1473-0395 201 µM -0.766776467169277 0.220159436786424 no 2664 0.221607215152657 3700 768876 SGTC_1005 4092-0690 4.4 µM -0.767018302253829 0.220086229354131 no 2665 0.221535316919449 3801 1529343 SGTC_1237 0330-0133 46.1 µM -0.767089866434415 0.220064568384907 no 2666 0.221514043249399 3723 X1237 YHR072W ERG7 SGTC_3296 9122258 64.045 µM -0.768653483572118 0.219591599798525 no 2667 0.221049523040249 3807 4730474 SGTC_1187 1391-0724 117 µM -0.769016054581971 0.219482011443242 no 2668 0.220941889925546 3855 6997986 SGTC_1050 3232-1156 69.3 µM -0.769807334769323 0.219242953376584 no 2669 0.220707094078077 3771 700529 SGTC_1758 st042942 75.2445 µM -0.769888751310841 0.219218364666475 no 2670 0.22068294353356 3722 669317 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.770792681663277 0.218945474068981 no 2671 0.220414912878942 3817 688664 SGTC_1948 st076329 66.6 µM -0.771520170822269 0.218725991886084 no 2672 0.220199335602165 3675 24208413 SGTC_3148 9097893 49.47 µM -0.771739702387291 0.218659784483891 no 2673 0.220134305445382 3779 17174100 SGTC_38 0929-0051 58.268 µM -0.772624701622345 0.218392999106798 no 2674 0.219872260625407 3813 1379719 SGTC_2326 6164455 177.58 µM -0.772893277683832 0.218312073235109 no 2675 0.219792771725001 3799 2888790 SGTC_1212 0520-0165 585 µM -0.7739081958088 0.218006419684123 no 2676 0.219492541282062 3881 5403258 SGTC_2253 7938677 135.83 µM -0.774691657964971 0.217770640426896 no 2677 0.219260940753527 3833 2301972 SGTC_3018 9082602 49.47 µM -0.775649139692549 0.217482690631174 no 2678 0.218978088831964 3780 17332089 SGTC_845 0330-0138 4.51 µM -0.775876362229849 0.21741438878087 no 2679 0.218910995315063 3732 9039800 SGTC_2175 5807670 165.306 µM -0.777079099907448 0.217053058756734 no 2680 0.218556051948914 3756 241186 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.778961599099231 0.216488209939512 no 2681 0.218001167935682 3859 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1168 k815-0004 80.5 µM -0.779031082711337 0.216467377489154 no 2682 0.217980702554314 3777 642433 SGTC_377 3970-0964 33.1 µM -0.779238475080328 0.21640520438485 no 2683 0.21791962475405 3784 16481235 SGTC_591 4299-0174 154 µM -0.77931557113225 0.216382094786567 no 2684 0.217896922205268 3793 5509088 SGTC_1738 st035555 74 µM -0.780063925152606 0.216157849353229 no 2685 0.217676624560832 3832 5331140 SGTC_1870 st057514 26.5 µM -0.780078988078539 0.216153337106411 no 2686 0.217672191713055 3802 5393161 SGTC_2182 6325192 200 µM -0.782374244641775 0.215466408216932 no 2687 0.216997332715387 3718 736248 SGTC_1640 st009078 66.4 µM -0.782948193371836 0.215294833836457 no 2688 0.21682876757895 3785 690618 SGTC_1447 4239-0816 81.9 µM -0.783459492931036 0.215142054391858 no 2689 0.216678665892724 3818 1341554 SGTC_2464 5717415 7.67 µM -0.785397367371453 0.214563577230922 no 2690 0.216110311913361 3799 5285744 SGTC_2723 salbutamol 83.58 µM -0.785876750682882 0.214420615585038 no 2691 0.215969848201212 3777 9884233 β2-adrenoceptor agonist SGTC_2877 9040724 71.43 µM -0.786331716115077 0.214284987081515 no 2692 0.215836588085762 3764 6463895 SGTC_555 4296-0685 37 µM -0.787081353039506 0.214061623750005 no 2693 0.215617122187236 3766 2908540 YHR072W ERG7 SGTC_197 4544-0043 41.561 µM -0.787191315615749 0.214028870478961 no 2694 0.215584940107937 3803 896523 SGTC_1184 1269-1718 139 µM -0.788384615250846 0.213673623850497 no 2695 0.215235883518436 3874 5403821 SGTC_1364 1653-0028 37.6 µM -0.788892984629214 0.21352238611942 no 2696 0.215087278160093 3822 5718652 SGTC_181 1447-1644 8.07 µM -0.789424774058899 0.213364247800319 no 2697 0.214931890473794 3802 534600 SGTC_1339 1486-1321 22.7 µM -0.792962858063219 0.212313866739863 no 2698 0.213899731413542 3848 3469382 SGTC_2492 derrusnin 100 µM -0.794309457905293 0.211914885533994 no 2699 0.213507649679984 3745 1715307 Part of coumarin class of compounds. SGTC_2698 st077697 67.5 µM -0.795878924013719 0.211450425686078 no 2700 0.213051206225445 3802 3154499 SGTC_2216 7189485 200 µM -0.79618954113369 0.211358573946275 no 2701 0.212960937844466 3817 731273 SGTC_2028 5153890 36.43 µM -0.797077047559931 0.211096260663957 no 2702 0.212703142788088 3791 2830968 YPR165W RHO1 SGTC_1896 st058441 89 µM -0.797242178373946 0.211047475312221 no 2703 0.212655197155521 3852 688759 SGTC_2458 5808907 16.39 µM -0.798343305534718 0.210722333280982 no 2704 0.2123356469355 3911 2731747 SGTC_3168 9103419 49.47 µM -0.799355238748495 0.21042378780235 no 2705 0.212042228638732 3761 16649256 SGTC_3344 9148862 3.898 µM -0.799695764698477 0.210323380035575 no 2706 0.211943543705248 3841 4905352 SGTC_316 k060-0003 58.6 µM -0.800993299854588 0.209941045639489 no 2707 0.211567762352218 3803 6152314 SGTC_1393 3470-5649 58.2 µM -0.801853695059514 0.209687745183501 no 2708 0.211318797067255 3803 4108395 SGTC_704 1310-0270 142 µM -0.802174856081595 0.209593241418128 no 2709 0.211225909422681 3829 5718033 SGTC_2102 5377816 72.7585 µM -0.8021803879805 0.209591613839601 no 2710 0.211224309671449 3856 1379702 SGTC_1587 estradiol valerate 56.1 µM -0.804150905687274 0.209012327170485 no 2711 0.210654914062117 3852 13791 A steroid. SGTC_63 0099-0242 26.702 µM -0.804756697054421 0.20883442819507 no 2712 0.210480047330484 3877 3898502 YLR359W ADE13 SGTC_2133 5320837 200 µM -0.806167724930783 0.208420406507334 no 2713 0.210073072859303 3834 2841355 SGTC_1269 0831-0796 3.05 µM -0.806549250843041 0.208308542943273 no 2714 0.209963111037653 3861 927758 SGTC_1473 k844-0725 134 µM -0.808496065287074 0.207738287819965 no 2715 0.209402535115588 3902 54682906 SGTC_2245 6637752 200 µM -0.808690529952618 0.207681376507082 no 2716 0.209346588363424 3911 681890 SGTC_1262 0737-0114 49.6 µM -0.809831723816009 0.207347584591563 no 2717 0.209018448508549 3879 765919 SGTC_2833 9001315 45.46 µM -0.810005977085223 0.207296644552158 no 2718 0.208968370247372 3832 2989378 SGTC_103 0844-0104 51.839 µM -0.810286700668393 0.207214595256234 no 2719 0.208887708583627 3832 5375804 SGTC_2673 kobusone 100 µM -0.812475718783338 0.206575452771209 no 2720 0.20825935688601 3885 6710676 An epoxy ketone and protein crosslinker. SGTC_1655 st012546 55.1 µM -0.813801424263281 0.20618894589496 no 2721 0.207879359524936 3814 720985 YLR208W SEC13 SGTC_1437 4092-1038 11.6 µM -0.81423460562463 0.206062745692009 no 2722 0.207755282159169 3859 3977136 SGTC_2402 5553605 200 µM -0.815635372090743 0.205654969279936 no 2723 0.207354356202763 3897 6758546 SGTC_1315 1237-0019 3.69 µM -0.817450957981795 0.205127148340144 no 2724 0.206835382324793 3867 825140 SGTC_2321 7390090 138.78 µM -0.817491020103806 0.205115510701899 no 2725 0.206823939494512 3874 649046 SGTC_159 3970-0959 50 µM -0.818136849402481 0.204927958024568 no 2726 0.206639524823193 3928 6615653 SGTC_33 0986-0033 35.816 µM -0.818791008163325 0.204738090402544 no 2727 0.206452831005739 3768 2848082 SGTC_2478 5763493 32.33 µM -0.81951770628321 0.204527291178404 no 2728 0.206245552012444 3813 1365576 YLR208W SEC13 SGTC_2771 fluoxetine 41.05 µM -0.820502833926368 0.20424173352075 no 2729 0.205964757184846 3815 3386 A selective serotonin reuptake inhibitor. SGTC_928 2764-0428 58.7 µM -0.82157343759699 0.203931668400623 no 2730 0.205659856046478 3919 662578 SGTC_1500 4488-1866 171 µM -0.8218007135301 0.203865881518633 no 2731 0.205595163791695 3967 2900003 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.827147257928703 0.202321931876429 no 2732 0.204076800680263 3927 5379071 SGTC_2085 5307070 144.047 µM -0.828214287921747 0.20201463926958 no 2733 0.203774576795945 3820 2840351 SGTC_667 1498-1044 59 µM -0.8296837116228 0.201591919331759 no 2734 0.203358816542895 3885 6739982 SGTC_2187 6125751 200 µM -0.83116277915596 0.201166960679495 no 2735 0.202940839220548 3869 874498 SGTC_999 SEC7.066 22.7 µM -0.831766472121845 0.200993664974542 no 2736 0.202770386069625 3869 740511 YDR170C SEC7 SGTC_948 3448-0295 75.3 µM -0.832563272090437 0.200765073258797 no 2737 0.202545540021303 3881 678569 SGTC_1492 4158-0558 28.5 µM -0.834621808008231 0.200175228392976 no 2738 0.201965339690934 3883 3967268 SGTC_1702 st027038 51 µM -0.835245622379202 0.19999668888935 no 2739 0.201789713618019 3918 5521182 SGTC_2400 5203494 178.7 µM -0.835858230267459 0.199821449961897 no 2740 0.201617331604597 3812 6777674 SGTC_1940 st075990 51.1 µM -0.836478818494745 0.199644022427149 no 2741 0.201442793978047 3979 1084979 SGTC_367 0335-0881 7.1 µM -0.836648938224533 0.199595401383414 no 2742 0.201394964392756 3876 23828853 SGTC_2432 5630864 12.22 µM -0.839283609642928 0.198843309616187 no 2743 0.200655089286346 3929 5714970 SGTC_1100 amiodarone 5.07 µM -0.839466604943629 0.198791135408953 no 2744 0.20060376076064 3972 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1929 genistein trimethyl ether 50.5 µM -0.839473623613834 0.198789134464255 no 2745 0.200601792244164 3831 136420 SGTC_2394 5221648 200 µM -0.844796744639609 0.197275070842005 no 2746 0.199112166247355 3971 788586 SGTC_1157 4092-0394 27.6 µM -0.846170948942012 0.196885339573789 no 2747 0.198728692896077 3999 3659885 SGTC_2233 sulbentine 40.3845 µM -0.846522120354492 0.196785820423726 no 2748 0.198630769578773 3870 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2178 5812956 200 µM -0.850479450254909 0.195666452104058 no 2749 0.197529290357557 3870 5403383 SGTC_3145 9085516 49.47 µM -0.850863000783838 0.195558167058629 no 2750 0.19742272994615 3967 25236195 SGTC_2231 micatex 6.853 µM -0.852028525979286 0.195229336132928 no 2751 0.197099129817354 3940 20737 An antifungal of unknown mechanism. SGTC_3037 9091026 49.47 µM -0.852181089507799 0.195186318097066 no 2752 0.197056795364003 3897 25236398 YIL048W NEO1 SGTC_3131 9127911 49.47 µM -0.853633955125135 0.194776945157949 no 2753 0.19665391929444 3942 45595681 SGTC_1731 st035964 63 µM -0.854009761123331 0.194671139640411 no 2754 0.196549790490684 3894 6739575 SGTC_2371 9071574 200 µM -0.854427868813157 0.19455346548492 no 2755 0.196433979947973 3909 45596039 SGTC_1931 st074438 57.1 µM -0.855298204267038 0.19430865314499 no 2756 0.19619304071191 3884 2787313 SGTC_1227 3909-8010 46.6 µM -0.856414388965461 0.193994961772758 no 2757 0.195884304236603 3907 15982272 SGTC_2203 7227154 166.4 µM -0.857834613278212 0.193596269829098 no 2758 0.195491896931445 3899 896304 SGTC_3024 9090631 49.47 µM -0.858210887720802 0.193490724118714 no 2759 0.195388012533498 3862 25236383 SGTC_898 1000-0849 28.3 µM -0.858440751131772 0.19342626426093 no 2760 0.195324566788752 3904 6751807 SGTC_333 3486-0131 40.1 µM -0.858994947287584 0.193270906693414 no 2761 0.195171651823059 3984 6744690 SGTC_803 4488-1585 147 µM -0.861392387261559 0.192599711115178 no 2762 0.194510983719308 3940 747204 SGTC_2301 7769476 200 µM -0.862960117080996 0.192161575447013 no 2763 0.194079697749707 3964 977820 SGTC_198 3454-2873 16.191 µM -0.863056239812321 0.192134731745586 no 2764 0.19405327314071 3892 710957 SGTC_3231 9132313 49.47 µM -0.86392085392842 0.191893378546034 no 2765 0.193815685035872 3909 4905967 SGTC_397 arbidol 50 µM -0.864100308626593 0.191843307829455 no 2766 0.193766394744978 3976 131410 A RNA synthesis inhibitor. SGTC_2364 9055074 200 µM -0.86458922678066 0.191706932470278 no 2767 0.193632143819518 3944 6470630 SGTC_1867 st057372 64 µM -0.865574540281377 0.191432276556657 no 2768 0.193361761220493 3910 688837 SGTC_1044 1222-0021 1.78 µM -0.868517495449752 0.190613365139071 no 2769 0.192555549415386 3916 4306703 SGTC_1085 doxorubicin 7.67 µM -0.868765755286726 0.190544382451105 no 2770 0.192487633645658 3943 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1939 st074455 53.6 µM -0.868904227163056 0.19050591264032 no 2771 0.192449758633242 3924 1644229 SGTC_1678 st019265 80.2 µM -0.870896589735999 0.1899529289428 no 2772 0.191905309508952 3937 5367020 SGTC_3064 1327-0027 10 µM -0.871033083880472 0.189915080905842 no 2773 0.191868044555129 3821 16000455 YPR107C YTH1 SGTC_1117 retinoic acid 1.10837 µM -0.871888792408386 0.189677909804138 no 2774 0.191634524213503 3952 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1883 5-benzylidenerhodanine 20 µM -0.874061168032622 0.189076625570643 no 2775 0.191042471681521 3936 1273210 SGTC_1483 3453-0561 55.9 µM -0.875458703879756 0.188690427784965 no 2776 0.190662185214036 3949 4546991 SGTC_1384 3089-0840 101 µM -0.875581069985257 0.188656636063344 no 2777 0.190628910048257 3908 1069836 SGTC_3079 9117512 49.47 µM -0.878735845604166 0.187786724819588 no 2778 0.189772259096868 3955 7185044 SGTC_2815 7968870 71.43 µM -0.880177607524453 0.187389993410291 no 2779 0.189381551056745 3939 2977326 YHR190W ERG9 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.881157636891388 0.187120613531956 no 2780 0.189116252382248 3945 6708739 YPR165W RHO1 SGTC_798 1287-0182 476 µM -0.881852165234228 0.186929854178374 no 2781 0.188928378858803 3955 1649755 SGTC_2367 9070478 135.38 µM -0.88222322939754 0.186827986924274 no 2782 0.188828051220802 3894 572802 SGTC_2555 cholic acid 100 µM -0.884649928199074 0.186162639135322 no 2783 0.188172734662913 3956 6708657 Influences liver metabolism. SGTC_40 0327-0103 19.753 µM -0.884706404429447 0.186147172093835 no 2784 0.188157500300124 3840 409036 SGTC_2949 9072542 2.23 µM -0.885643061009471 0.185890767832091 no 2785 0.187904949855335 4025 16457352 SGTC_1761 st044296 37 µM -0.886047487165691 0.185780126268716 no 2786 0.187795969274961 3947 1826700 SGTC_3108 9121785 49.47 µM -0.886815471412486 0.185570136152483 no 2787 0.187589128292217 3818 17140271 SGTC_1808 st050063 61.5 µM -0.886966632825163 0.185528821406854 no 2788 0.187548432617217 3911 4011993 SGTC_2079 5212404 121 µM -0.888276407552813 0.185171078836213 no 2789 0.187196043536585 3896 758462 SGTC_2585 alliin 100 µM -0.890120148079318 0.184668219229599 no 2790 0.186700687717674 4015 87310 A garlic compound which reacts with lipids. SGTC_2373 9071805 200 µM -0.89387827128063 0.183645865373386 no 2791 0.18569351236158 3915 10149009 SGTC_2080 5212524 12.4 µM -0.894427792114415 0.183496670697749 no 2792 0.185546524011949 3855 260183 SGTC_2291 7917025 104.35 µM -0.896563421340567 0.182917565894601 no 2793 0.184975962011909 3904 2964612 SGTC_527 4476-4215 268 µM -0.89790734830512 0.182553727256957 no 2794 0.184617473375479 3943 4418754 SGTC_2197 6588183 93.1375 µM -0.899878618213589 0.182020867694386 no 2795 0.184092425013884 3912 884136 SGTC_360 0957-0399 1.01 µM -0.900453682494334 0.181865603852736 no 2796 0.18393943177315 3989 6752301 YPR165W RHO1 SGTC_2816 7982706 58.44 µM -0.901003729401355 0.181717172082582 no 2797 0.1837931683998 4033 2981853 SGTC_1219 1469-0211 33.1 µM -0.905259644761584 0.180571264261218 no 2798 0.182663925090945 3989 6822282 SGTC_2333 9017922 200 µM -0.905629870469298 0.180471795482962 no 2799 0.182565896497915 4046 3163164 SGTC_1653 st012112 65 µM -0.905823517190992 0.180419781987462 no 2800 0.18251463568798 3953 720429 SGTC_566 0958-0068 16.5 µM -0.908666655589084 0.17965719820215 no 2801 0.18176305514887 3872 6815365 SGTC_75 0159-0059 199.013 µM -0.90893077746346 0.179586458655086 no 2802 0.181693333243115 4042 5377270 SGTC_3019 9081971 49.47 µM -0.910705855069351 0.179111495316694 no 2803 0.181225189130029 4020 16451803 SGTC_201 4262-0159 12.803 µM -0.910905371899991 0.179058159390424 no 2804 0.181172617499504 4009 1341029 SGTC_1295 1013-0063 9.78 µM -0.914510541831037 0.178096127839846 no 2805 0.180224320583911 3987 6826038 SGTC_288 1315-0019 35.1 µM -0.915696932575477 0.177780256029499 no 2806 0.179912937161674 4060 6811474 SGTC_2453 5731132 22.18 µM -0.91871415142913 0.176978527035515 no 2807 0.179122552942883 4036 1362040 SGTC_2504 purpurogallin 52.29 µM -0.918987499066498 0.176906006716461 no 2808 0.179051055446831 3903 5281571 An antioxidant. SGTC_1261 0712-0010 12.7 µM -0.919223820197029 0.176843324830034 no 2809 0.178989257171159 4014 2840123 SGTC_1058 3448-5425 97.3 µM -0.920625774509713 0.176471758770698 no 2810 0.178622920375265 3865 7279705 SGTC_2437 5741531 144.16 µM -0.920693588192058 0.176453798345125 no 2811 0.178605212343274 4030 2262990 SGTC_1129 3453-1384 223 µM -0.921616185521267 0.176209563712415 no 2812 0.178364406452881 4124 1084452 SGTC_258 haloperidol 50.781 µM -0.92251896572296 0.175970782382661 no 2813 0.178128971122649 4028 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_282 k297-0036 65.7 µM -0.924176038467649 0.175533027518466 no 2814 0.177697334508626 4008 5061378 SGTC_2702 st077768 96.8 µM -0.92529520935819 0.17523776294996 no 2815 0.177406185007152 3998 6484119 SGTC_2038 4100038 30.985 µM -0.927812381032713 0.174574823333913 no 2816 0.176752450275186 4004 3596803 SGTC_1249 0481-0015 10.2 µM -0.927924399811264 0.174545358361239 no 2817 0.176723393313062 3957 4227577 SGTC_3315 9136395 68.55 µM -0.929118576974362 0.174231443085359 no 2818 0.176413819039618 3985 16876844 SGTC_564 3555-0129 330 µM -0.929858673538728 0.17403707290093 no 2819 0.176222131321162 3861 563260 SGTC_2803 7707263 71.43 µM -0.932164613385003 0.173432352494635 no 2820 0.175625730051423 3982 2199229 SGTC_1091 telmisartan 47.6 µM -0.932641267912922 0.173307519395877 no 2821 0.175502609272992 4062 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1683 st010134 710 nM -0.932952991502602 0.173225911716195 no 2822 0.175422120067006 4004 3818134 SGTC_1108 betulinic acid 729.144 nM -0.93329944466655 0.173135240724347 no 2823 0.17533269090399 4008 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2296 7971656 126.45 µM -0.939225502228638 0.171589002094747 no 2824 0.173807489088694 4068 666570 SGTC_993 3909-8757 62.7 µM -0.93934774338205 0.171557199850783 no 2825 0.173776116719365 3976 4288324 YLR208W SEC13 SGTC_1489 4065-0444 182 µM -0.939470219208142 0.171525340331765 no 2826 0.173744687735439 3980 2877968 SGTC_402 epigallocatechin gallate 10 µM -0.941316996334728 0.171045398348655 no 2827 0.173271217671961 3960 65064 An antioxidant. SGTC_2539 epi(13)torulosol 80 µM -0.941903218145142 0.17089323031834 no 2828 0.173121096181578 4063 6708597 SGTC_1362 1611-0397 101 µM -0.942153261616489 0.170828351855966 no 2829 0.173057089488817 3972 27816 SGTC_2304 7443016 91.4 µM -0.94508237850308 0.17006951167699 no 2830 0.172308410440219 3939 939854 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.946171517110918 0.169787902673103 no 2831 0.172030555634931 3947 1241132 A phosphatase inhibitor. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.94661575499974 0.169673125891438 no 2832 0.171917306376832 4049 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3001 9076041 71.4286 µM -0.946839734286585 0.169615275724224 no 2833 0.171860225546833 4008 16004211 SGTC_229 benomyl 22.8748 µM -0.947704223022427 0.169392111179693 no 2834 0.171640025235493 4045 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2968 9090663 33.37 µM -0.947980019406481 0.169320955038435 no 2835 0.17156981304304 4002 25236811 SGTC_111 0083-0039 52.457 µM -0.948962981470892 0.169067504499043 no 2836 0.171319720030973 3923 759313 SGTC_1188 1403-0014 4.57 µM -0.951504700294965 0.168413268600103 no 2837 0.170674116815181 4039 9614867 SGTC_1945 st075991 56.6 µM -0.952505511915043 0.168156108013009 no 2838 0.170420335946804 4063 1084980 SGTC_2271 7849410 118.62 µM -0.95291134875128 0.16805189944549 no 2839 0.170317494753361 3917 972430 SGTC_1175 0741-0056 27.6 µM -0.952962524548484 0.168038761754964 no 2840 0.170304529359807 4129 765927 SGTC_1921 5740136 50 µM -0.954133395630099 0.167738359962701 no 2841 0.170008061779699 3956 1774243 SGTC_1046 2001-0062 216 µM -0.955224950467657 0.167458619422874 no 2842 0.169731975419528 3946 739778 SGTC_524 r073-0010 27.8 µM -0.955746950596026 0.167324949033995 no 2843 0.169600047910359 3959 2772106 SGTC_1202 1988-0068 29.6 µM -0.961469089943962 0.165864171224615 no 2844 0.168158179996687 4011 2850480 SGTC_1404 3909-7820 48.3 µM -0.961758565815987 0.165790492009265 no 2845 0.168085447895828 4008 23741373 SGTC_3174 9107204 49.47 µM -0.962982816679929 0.165479122001777 no 2846 0.167778073300262 4092 3938802 SGTC_2093 5331342 194.4 µM -0.964031247384177 0.165212770126964 no 2847 0.167515130026206 4130 33839 SGTC_2286 7945697 125 µM -0.964282349612948 0.165149019280185 no 2848 0.167452193767809 4083 1245733 SGTC_871 0574-0004 149 µM -0.964802268935115 0.165017070690404 no 2849 0.167321929634651 4029 9551173 SGTC_1146 3579-1023 7 µM -0.965948368588912 0.164726447030051 no 2850 0.16703500873653 4091 X1146 SGTC_314 1671-0008 2.74 µM -0.966630276517168 0.164553688804398 no 2851 0.166864446784756 3940 3913060 SGTC_1408 3909-7976 48.8 µM -0.968558880296911 0.164065721844482 no 2852 0.166382663973838 4086 24152374 SGTC_1848 st056003 16.4 µM -0.970109353113017 0.163674109305276 no 2853 0.165995993689324 4088 146492 SGTC_828 2074-0507 139 µM -0.971687676233682 0.163276086258921 no 2854 0.16560297477281 4142 X828 SGTC_2565 isoliquiritigenin 100 µM -0.97272961444349 0.163013674178326 no 2855 0.165343851330284 4154 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_188 3229-0966 278.469 µM -0.974352418928305 0.162605517286649 no 2856 0.164940792915839 4092 5722370 SGTC_1226 3909-7979 35.4 µM -0.976732848982338 0.162008011489332 no 2857 0.164350714057972 4069 6615510 SGTC_1275 0867-0008 21.1 µM -0.978585723934294 0.161543917060011 no 2858 0.163892357972981 4018 3422836 SGTC_1441 4106-0040 13 µM -0.980349301229044 0.161102995152891 no 2859 0.16345686322501 4050 2904180 SGTC_2162 5663267 200 µM -0.985154560839753 0.159905593848285 no 2860 0.162274078227353 4061 6456493 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.986624358946513 0.15954050692105 no 2861 0.161913412062745 4061 140250 A respiratory chain inhibitor. SGTC_3299 9121982 43.1275 µM -0.986732031133523 0.159513783414685 no 2862 0.16188701148637 4141 17594604 YPL160W CDC60 SGTC_3048 9093155 49.47 µM -0.987227544866107 0.159390838039861 no 2863 0.161765550636987 4034 25236002 SGTC_1501 4491-0275 38.4 µM -0.987281691424512 0.159377407120105 no 2864 0.161752281775602 4022 5104718 SGTC_3156 9099931 49.47 µM -0.988386523833474 0.159103517998353 no 2865 0.161481692444045 4098 18111053 SGTC_1397 3532-0190 20.1 µM -0.99017093623613 0.158661811826461 no 2866 0.161045287878845 4025 5322280 SGTC_3331 9141060 1.957 µM -0.990897713526879 0.158482138986359 no 2867 0.160867764478616 4037 4906567 YPR165W RHO1 SGTC_2568 diosmetin 100 µM -0.991265200992927 0.158391340081567 no 2868 0.160778050243689 4138 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_52 0329-0193 875 nM -0.991294866789346 0.158384011737337 no 2869 0.160770809396892 4191 3739292 SGTC_191 3914-0123 66.505 µM -0.99372887948684 0.157783495205233 no 2870 0.160177439459942 4057 3144412 SGTC_2350 9023895 38.85 µM -0.994320797825059 0.157637684214453 no 2871 0.160033356757121 4104 2997209 SGTC_1560 lithocholic acid 53.1 µM -0.995191369761634 0.15742339161979 no 2872 0.159821599198817 3958 9903 A bile acid which acts as a detergent. SGTC_2354 9060492 162 µM -0.995724638591723 0.157292221299958 no 2873 0.159691977679233 4145 6471895 SGTC_1839 st053978 48 µM -0.995865612727245 0.15725755732592 no 2874 0.159657722631319 4082 3788398 SGTC_1491 4138-0063 26.5 µM -0.995910018130774 0.157246639570714 no 2875 0.159646933639272 4047 23883227 SGTC_2810 7959871 45.46 µM -0.998226165692332 0.156677869795011 no 2876 0.159084850582869 4055 2974535 SGTC_1368 1852-0141 284 µM -0.999426793348998 0.156383568646742 no 2877 0.158793992911757 4112 2838987 SGTC_158 k038-0087 26.446 µM -1.00042977956231 0.156137993205326 no 2878 0.158551282206644 4008 X158 SGTC_1490 4089-0339 670 nM -1.00177825213969 0.155808228084049 no 2879 0.158225351550212 4033 742542 SGTC_1643 st009866 20.2 µM -1.00209264912018 0.155731409260937 no 2880 0.158149423924016 4033 3156273 YOR207C RET1 SGTC_2266 7929956 200 µM -1.00512846975263 0.154990930995798 no 2881 0.157417496436256 4055 2967153 SGTC_1573 oleylamine 1.06 µM -1.00591251243545 0.154800070650348 no 2882 0.157228828371606 4081 5356789 An amine of the fatty acid oleic acid. SGTC_526 4469-0568 170 µM -1.00630245524091 0.154705204297069 no 2883 0.157135049891356 4033 2901964 SGTC_279 1273-0055 2.93 µM -1.00787943879682 0.15432194330715 no 2884 0.156756171782837 4112 2847562 SGTC_3191 9110352 49.47 µM -1.0082333444284 0.154236018456564 no 2885 0.15667122687335 4042 17122424 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.01142546380982 0.153462432838457 no 2886 0.155906419409786 4143 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2764 methyldopa 94.69 µM -1.01641497307567 0.152258420028222 no 2887 0.154715909212328 4108 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_738 1315-0003 72.4 µM -1.01667197997958 0.152196572282691 no 2888 0.154654749780259 4161 6251474 SGTC_1034 k072-0165 12.7 µM -1.01884842122988 0.151673488691732 no 2889 0.154137466875819 4128 5835461 SGTC_2138 5575593 77.673 µM -1.02027578676461 0.151331086701792 no 2890 0.153798841717159 4092 762213 SGTC_966 1300-0360 30.2 µM -1.02044476898155 0.151290584650853 no 2891 0.153758785359549 4090 70588 SGTC_2970 9090938 41.86 µM -1.02059421479364 0.151254771139205 no 2892 0.153723365760361 4191 17217104 SGTC_2600 tangeritin 87.95 µM -1.02226297523937 0.150855248912339 no 2893 0.153328225944606 4051 68077 A bioactive flavone. SGTC_986 1493-0483 84 µM -1.02310971738703 0.150652797098612 no 2894 0.153127986473694 4064 40079 SGTC_892 0929-0076 29 µM -1.02375166123322 0.150499432172871 no 2895 0.152976293720805 4091 5751038 SGTC_178 4092-0806 87.505 µM -1.02542760436518 0.150099527851647 no 2896 0.152580734360797 4000 2169044 SGTC_1053 3366-3204 134 µM -1.02634566385884 0.14988076613139 no 2897 0.152364340111538 4154 3632071 YPR165W RHO1 SGTC_2225 6654152 15.4 µM -1.02755798430901 0.149592211777963 no 2898 0.152078898362992 4009 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_386 1509-0011 3.07 µM -1.02824334479585 0.149429247627251 no 2899 0.151917686964503 4120 3107280 SGTC_280 3448-3607 3.04 µM -1.0304201776446 0.148912429251652 no 2900 0.151406402652545 4094 626179 SGTC_1414 3917-0015 5.4 µM -1.03174814141262 0.148597734537639 no 2901 0.151095059326371 4097 6618702 SGTC_31 0508-1974 57.237 µM -1.03268901788059 0.148375039282833 no 2902 0.150874727276802 4049 6810525 SGTC_583 1488-1091 88.9 µM -1.0341403314434 0.148031967040712 no 2903 0.150535281961918 4244 4303273 SGTC_2664 lyso-paf C-16 73.48 µM -1.03560227127637 0.147686920053277 no 2904 0.150193865969307 4085 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2315 7733312 200 µM -1.03592617385321 0.14761054552769 no 2905 0.150118292862749 4024 726316 SGTC_736 0958-0254 92.6 µM -1.03717306183975 0.147316782875671 no 2906 0.149827605006713 4221 6812352 SGTC_882 0843-0131 351 µM -1.03909772990521 0.146864107161557 no 2907 0.149379643311485 4132 5425421 SGTC_3314 9135860 59.4275 µM -1.03970822495214 0.146720715820598 no 2908 0.149237739084292 4131 25252478 SGTC_491 tetrandrine 80.3 µM -1.039899262034 0.146675864876688 no 2909 0.149193352684589 4147 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1507 4075-3230 155 µM -1.04284261155768 0.145985999549147 no 2910 0.148510596178959 4043 659771 SGTC_1056 3448-1962 115 µM -1.04593223698528 0.145264198837677 no 2911 0.147796159694304 4152 715507 SGTC_753 1322-0200 289 µM -1.04913264275741 0.144519053482764 no 2912 0.147058537112824 4215 5403907 SGTC_90 0870-0863 4.608 µM -1.05045198079002 0.144212625093829 no 2913 0.146755178718946 4153 1738164 SGTC_2442 5158906 48.48 µM -1.05053045737303 0.144194411998136 no 2914 0.146737147658686 4176 1893835 SGTC_1735 st034310 56.75 µM -1.05600331059618 0.142928079160942 no 2915 0.14548335117881 4210 871153 SGTC_209 4077-0173 175.592 µM -1.05899370445299 0.142239333304354 no 2916 0.144801323428539 4123 15993494 SGTC_2136 5328288 199.296 µM -1.05991824924704 0.142026847923385 no 2917 0.144590896283358 4139 262395 SGTC_152 4469-0003 551.229 µM -1.06087991442165 0.141806059376158 no 2918 0.144372239193278 4061 697280 SGTC_155 k072-0202 43.6 µM -1.06172685471699 0.14161180309328 no 2919 0.144179852141768 4110 5857737 SGTC_568 1193-0097 7.48 µM -1.06269952290786 0.141388932060582 no 2920 0.143959118650916 3998 3646150 SGTC_270 tamoxifen 5.46 µM -1.06308052440203 0.141301696622088 no 2921 0.143872717831201 4210 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_988 1497-1057 103 µM -1.06316466686939 0.141282435987162 no 2922 0.143853641315341 4119 3533044 SGTC_3260 9137109 49.47 µM -1.06455268276814 0.140964968972538 no 2923 0.143539200952513 4088 17478346 SGTC_1831 st055328 12 µM -1.06641356615395 0.140540107440824 no 2924 0.143118365909691 4160 1103068 SGTC_2053 5265679 138 µM -1.06889563912829 0.139974775233633 no 2925 0.142558348599565 4083 764595 SGTC_1958 st076513 41.9 µM -1.07220194290759 0.13922411445938 no 2926 0.141814668969176 4121 732122 YGL099W LSG1 SGTC_2645 abamectin 100 µM -1.07288797613944 0.139068701800651 no 2927 0.141660690744512 4124 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2142 5622915 118.518 µM -1.07486391475614 0.138621736515147 no 2928 0.141217829930089 4184 5322196 SGTC_2490 carminic acid 95.39 µM -1.07613929133141 0.13833376144774 no 2929 0.140932482812539 4128 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2425 5628681 7.85 µM -1.07797399772401 0.137920207589661 no 2930 0.140522680153204 4241 5714958 SGTC_1715 st032160 10.2275 µM -1.08678104649476 0.135946792975789 no 2931 0.138566793017176 4114 5289825 SGTC_916 4466-0038 42 nM -1.0874353071295 0.13580096670693 no 2932 0.138422237277898 4243 5722064 YGL116W CDC20 SGTC_897 1000-0139 31.4 µM -1.08871319636372 0.135516450704677 no 2933 0.138140190298509 4144 6151020 SGTC_2200 6600604 21.907 µM -1.09347071783265 0.134460803468347 no 2934 0.137093589424718 4200 2904777 SGTC_1163 k060-0048 49.9 µM -1.0958078727191 0.133944285158457 no 2935 0.136581431242672 4179 6809982 SGTC_2654 protoveratrine a 100 µM -1.09655427307186 0.133779616059056 no 2936 0.136418142980031 4185 5702278 A heart drug and vasodilator. SGTC_54 0159-0055 9 µM -1.10096002942882 0.13281046374142 no 2937 0.13545702687022 4209 3319099 SGTC_499 genistein 192 µM -1.10647670389838 0.131603770317049 no 2938 0.134260120917178 4290 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1172 0370-0043 85 µM -1.10767107485436 0.131343518406809 no 2939 0.13400194786343 4225 376585 SGTC_930 2810-3379 265 µM -1.10879704978121 0.131098495532166 no 2940 0.133758871741947 4243 1015764 SGTC_2519 cryptotanshinone 88.04 µM -1.10958579161384 0.13092704597321 no 2941 0.133588778336859 4182 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1068 loratadine 26.9 µM -1.11087032196696 0.130648158156462 no 2942 0.133312085842653 4225 3957 A H1 histamine antagonist. SGTC_1899 st063254 59.6 µM -1.11279464995135 0.130231131152862 no 2943 0.132898316840798 4150 3093813 SGTC_689 0833-0039 98 µM -1.11316227085053 0.130151567801987 no 2944 0.132819371700598 4161 5374726 SGTC_375 3970-0961 9.27 µM -1.11407540611722 0.12995408558761 no 2945 0.132623419247741 4154 2898222 SGTC_2279 7948423 32.93 µM -1.1150017974552 0.1297539485733 no 2946 0.132424825735303 4200 1247112 SGTC_2004 4023728 41.89 µM -1.11641877240947 0.129448239282549 no 2947 0.132121460847341 4180 360084 YDR527W RBA50 SGTC_3330 9141424 71.43 µM -1.11839208619067 0.129023333116042 no 2948 0.131699786388664 4286 27261020 SGTC_1898 st060199 18.6 µM -1.11930480486738 0.128827128349087 no 2949 0.131505063345806 4194 688866 SGTC_2676 harmalol 100 µM -1.1214316817293 0.128370722529057 no 2950 0.131052078380715 4170 5459187 A monoamine oxidase inhibitor SGTC_645 0845-0943 5.41 µM -1.12436031280289 0.127744107490714 no 2951 0.130430100685602 4221 1885106 SGTC_2563 tomatine 8.54 µM -1.12577039930306 0.12744316237346 no 2952 0.130131358247765 4197 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2110 5483698 200 µM -1.12852856510598 0.126855932180273 no 2953 0.129548380073601 4187 2848765 YHR062C RPP1 SGTC_2381 9035592 200 µM -1.13641023886936 0.125188268323001 no 2954 0.12789245631968 4218 4749657 SGTC_3153 9100258 49.47 µM -1.13682594537053 0.125100737022167 no 2955 0.127805527413829 4167 25236848 SGTC_2902 5787006 60.46 µM -1.13909597123726 0.124623513608636 no 2956 0.127331563842854 4187 591003 SGTC_2039 Aminomethylbenzodioxan 200 µM -1.13981353158395 0.12447292724158 no 2957 0.127181997515014 4207 15053 SGTC_1152 3909-8331 15.9 µM -1.1434626899195 0.123709087982064 no 2958 0.126423268508006 4195 16001939 SGTC_3073 9114972 49.47 µM -1.14555509994098 0.123272589572873 no 2959 0.125989642244549 4232 41905075 SGTC_2648 atorvastatin 78.68 µM -1.14852638425454 0.122654605018454 no 2960 0.125375663740375 4231 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2144 5628481 200 µM -1.14900923769228 0.122554384064132 no 2961 0.125276085776467 4229 2818399 SGTC_2057 5236571 38.335 µM -1.15040402491063 0.122265205077478 no 2962 0.124988751583193 4218 54684039 YBR257W POP4 SGTC_1048 3161-0300 24.5 µM -1.15277069974883 0.121775622782575 no 2963 0.124502256865647 4245 2165101 SGTC_2370 9071495 200 µM -1.15321272969124 0.121684335106403 no 2964 0.124411539922389 4248 21791103 SGTC_2468 5987765 72.9 µM -1.15492413336784 0.121331350924421 no 2965 0.124060747832576 4289 26772094 SGTC_430 0958-0115 16.4 µM -1.15573052887011 0.121165278266781 no 2966 0.123895698374547 4195 6833180 SGTC_1757 st041620 31.8375 µM -1.15595779389209 0.121118503195971 no 2967 0.123849210550074 4314 5289815 SGTC_1013 4112-3890 241 µM -1.15607081589471 0.121095246043542 no 2968 0.123826096065852 4179 705171 SGTC_2945 9067681 61.76 µM -1.15632203652721 0.121043562259703 no 2969 0.123774728962926 4321 16456930 SGTC_1380 2291-0730 164 µM -1.15817935858596 0.120661935660323 no 2970 0.123395424997603 4256 2999191 SGTC_1389 3405-0187 19 µM -1.15847461775098 0.120601346459036 no 2971 0.123335202002463 4215 799890 SGTC_225 nsc-122657 1.016 µM -1.16008792276098 0.120270663530135 no 2972 0.12300650540556 4250 275685 SGTC_193 1273-0060 1.558 µM -1.1604476788658 0.120197010661233 no 2973 0.122933292105513 4087 2847393 YHR072W ERG7 SGTC_998 3996-0085 177 µM -1.16516969482116 0.119233217603454 no 2974 0.121975155014098 4293 715391 SGTC_869 0564-0080 44.1 µM -1.16681907854825 0.118897856936407 no 2975 0.121641720311772 4265 6843321 SGTC_1902 st060212 70.5 µM -1.16788311228299 0.118681866265948 no 2976 0.121426958498472 4262 688944 SGTC_899 1083-0020 478 µM -1.16917028789977 0.11842095021263 no 2977 0.121167514773334 4324 767123 SGTC_2005 4024620 188 µM -1.16981682083659 0.118290048280138 no 2978 0.121037346499229 4222 236743 SGTC_2034 5197015 53.07 µM -1.17048834959064 0.118154193853681 no 2979 0.120902249940439 4272 780676 SGTC_2549 cedrol 20.94 µM -1.174152431412 0.117414870900697 no 2980 0.120166987730429 4201 6708665 A sedative which affects the nervous system. SGTC_2096 5468907 200 µM -1.17719601054184 0.11680324580523 no 2981 0.11955864031569 4270 759785 SGTC_1377 2944-0135 198 µM -1.18027094292691 0.116187617131737 no 2982 0.118946235512468 4283 1894137 SGTC_2456 5770359 74.46 µM -1.18056503333942 0.116128858504046 no 2983 0.118887780619266 4283 3118787 SGTC_2317 5986382 200 µM -1.18089841676122 0.116062274727397 no 2984 0.118821540188723 4293 877883 SGTC_1078 idebenone 36.1 µM -1.18136618212204 0.115968897704756 no 2985 0.118728643173125 4316 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3070 9117005 49.47 µM -1.18237446840859 0.115767801350627 no 2986 0.118528574599986 4352 8779016 SGTC_1916 st067606 49.2 µM -1.18255251401571 0.115732317017475 no 2987 0.118493270777262 4186 19590279 SGTC_1289 0976-0073 69.1 µM -1.1852755229236 0.115190586035654 no 2988 0.11795426399529 4335 3391136 SGTC_376 3970-0862 59.1 µM -1.18552393975729 0.115141254452704 no 2989 0.117905177530894 4308 3135186 SGTC_1079 idarubicin 2.36 µM -1.18816019687214 0.114618661617193 no 2990 0.117385150928771 4280 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1051 3253-3903 78 µM -1.19275337559983 0.113712179422833 no 2991 0.116482987444368 4272 5509239 SGTC_3328 9140624 29.0385 µM -1.19616029377606 0.113043119451514 no 2992 0.11581700619955 4291 4904392 SGTC_2109 5483026 200 µM -1.19794205178142 0.112694333866646 no 2993 0.115469788635821 4299 759335 SGTC_3078 9116413 49.47 µM -1.20400358531187 0.111513522714535 no 2994 0.114294096395959 4216 17177322 SGTC_2242 6630449 61.2675 µM -1.20580379363965 0.11116454615945 no 2995 0.113946576210076 4339 691249 YDR170C SEC7 SGTC_2875 9039966 71.43 µM -1.20763564215765 0.110810239481178 no 2996 0.113593721584367 4301 6463691 SGTC_492 tmb-8 126 µM -1.20827622701977 0.110686532008048 no 2997 0.113470514776182 4262 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_896 0964-0007 44.5 µM -1.20931962402095 0.110485246834641 no 2998 0.113270037221883 4263 6756758 SGTC_2434 5670830 169.91 µM -1.21137065739802 0.110090340385951 no 2999 0.112876689936306 4318 1549830 SGTC_3051 9093778 49.47 µM -1.21158330067253 0.110049456007662 no 3000 0.112835965055551 4368 17217378 SGTC_2297 7971671 152.32 µM -1.21168032353995 0.11003080528867 no 3001 0.112817386976495 4307 909016 SGTC_329 k048-0121 21.3 µM -1.21473562710507 0.109444643600722 no 3002 0.112233469837219 4318 6832902 SGTC_1628 st004252 77.7 µM -1.2192565882268 0.108581414592186 no 3003 0.111373409968829 4327 692968 SGTC_2937 9044753 11.33 µM -1.21962908679719 0.108510508989885 no 3004 0.111302757415249 4235 6465530 YGL099W LSG1 SGTC_3026 9090633 49.47 µM -1.22427489963383 0.107628969519248 no 3005 0.110424271213303 4306 25236842 SGTC_3087 9117406 49.47 µM -1.22435504157276 0.107613808055298 no 3006 0.110409160753707 4332 42546093 SGTC_2341 7987486 176.74 µM -1.2314656146045 0.10627473037398 no 3007 0.109074384756633 4334 1258686 SGTC_2481 5478948 45.16 µM -1.23264750722917 0.10605332544135 no 3008 0.108853652123549 4327 77792 SGTC_283 0987-0079 11.7 µM -1.23599131240402 0.105428733325868 no 3009 0.108230896478151 4309 411556 SGTC_109 0132-0036 33.701 µM -1.23881416123461 0.104903525831857 no 3010 0.107707164137139 4146 67274 A color developer. SGTC_424 splitomicin 100 mM -1.24005130595325 0.104673945809076 no 3011 0.107478208992916 4356 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2473 5854593 8.94 µM -1.2403323607344 0.104621840538705 no 3012 0.107426243849345 4213 2872951 SGTC_2622 2-methoxyxanthone 59.94 µM -1.24046579553271 0.104597109390691 no 3013 0.10740157899111 4296 71034 A hepatoprotective. SGTC_597 k018-0003 82.8 µM -1.24067621302943 0.104558118676532 no 3014 0.107362692500852 4390 6786234 SGTC_3188 9110789 49.47 µM -1.24459133335535 0.103834559974259 no 3015 0.106641003853359 4308 849217 SGTC_2848 9016370 25.97 µM -1.24614189288485 0.10354900528773 no 3016 0.106356153589283 4312 7894410 SGTC_2041 5107442 45.335 µM -1.25000548295659 0.102839957631396 no 3017 0.10564877221328 4363 793005 SGTC_920 mycophenolic acid 780.421 nM -1.25087474702734 0.102680917227642 no 3018 0.105490089260806 4301 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2904 7225135 42.03 µM -1.25384665289319 0.102138528293086 no 3019 0.104948874188209 4404 4446116 SGTC_1009 4106-0057 9.87 µM -1.25550553223007 0.101836681762004 no 3020 0.104647650530071 4334 2928005 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.25895850694668 0.101210468494103 no 3021 0.104022659714262 4285 688761 SGTC_2874 9043904 71.43 µM -1.25986977361704 0.101045674935901 no 3022 0.103858172132623 4272 4463428 SGTC_1016 4226-1401 38 µM -1.26131748108612 0.10078427367728 no 3023 0.103597242725486 4322 2901613 SGTC_2090 5301565 104.445 µM -1.26171364081187 0.100712828213184 no 3024 0.103525923338821 4330 2056344 SGTC_2802 7925815 54.55 µM -1.26325219747368 0.100435707361287 no 3025 0.103249279751826 4308 1262923 SGTC_3353 9151644 39.2805 µM -1.26389205690593 0.100320621495223 no 3026 0.10313438658278 4341 4909158 SGTC_3030 9087619 49.47 µM -1.27217644175576 0.0988392634537381 no 3027 0.101655217978744 4363 25236973 SGTC_779 1360-0071 233 µM -1.2722159532767 0.0988322368278908 no 3028 0.101648200442578 4382 7566 SGTC_691 1548-0686 185 µM -1.27594087963821 0.0981714461601878 no 3029 0.100988209386597 4323 46495133 SGTC_638 3970-0837 4.09 µM -1.27812341429339 0.0977857779739034 no 3030 0.100602957178393 4332 4118451 YLR208W SEC13 SGTC_2287 7945887 168.79 µM -1.28057319958745 0.0973542091732379 no 3031 0.100171809253082 4365 1245853 SGTC_2656 pseudo-anisatin 100 µM -1.2870678528191 0.096216837990503 no 3032 0.0990353195626825 4407 6708809 A neurotoxin. SGTC_416 estradiol valerate 100 µM -1.28771460386912 0.096104113204316 no 3033 0.0989226640237073 4369 13791 A steroid. SGTC_1241 0364-0022 50.8 µM -1.29457475746356 0.0949144022238268 no 3034 0.0977334824551914 4347 4563895 SGTC_2756 carbadox 75.1 µM -1.29899997248466 0.0941527451812007 no 3035 0.0969719693083347 4304 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_426 0988-0037 14.6 µM -1.30188169179982 0.0936591808226318 no 3036 0.0964784159839869 4400 5383008 SGTC_3159 9100096 49.47 µM -1.30275537415015 0.0935099195800664 no 3037 0.0963291452633617 4312 25236875 SGTC_466 geldanamycin 89.2 µM -1.30545260626954 0.0930502287203941 no 3038 0.0958693876349989 4368 5288382 HSP90 inhibitor. SGTC_781 4335-2806 94.4 µM -1.31049010899585 0.0921961608442629 no 3039 0.0950150440565105 4429 845254 SGTC_1381 2324-0066 62.1 µM -1.31141623418201 0.092039777303074 no 3040 0.0948585885291815 4410 10885928 SGTC_34 0469-0683 81.75 µM -1.31151527724818 0.0920230647327448 no 3041 0.0948418678701898 4337 3690923 SGTC_1783 st039459 87.517 µM -1.31412886894019 0.091582857781138 no 3042 0.0944014202816961 4452 729761 SGTC_3053 9095903 49.47 µM -1.31466866518128 0.0914921347087954 no 3043 0.0943106409937534 4496 17174018 SGTC_2275 7947463 200 µM -1.32276100397593 0.0901400367574107 no 3044 0.0929574346281279 4335 1225414 SGTC_142 0335-0849 62.6745 µM -1.32330745099544 0.090049272260914 no 3045 0.0928665774274741 4359 3889043 YPR107C YTH1 SGTC_685 1278-0033 54.9 µM -1.3235490367837 0.0900091666716789 no 3046 0.0928264301370755 4456 3590572 SGTC_1827 berberine 7.24 µM -1.32568240104963 0.0896555834138901 no 3047 0.0924724595972906 4289 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2081 5214970 32.255 µM -1.32851031819919 0.0891884783143599 no 3048 0.0920047885882046 4329 2063512 SGTC_3049 9092223 49.47 µM -1.32968864448719 0.0889943820307378 no 3049 0.0918104388896871 4370 8623917 SGTC_2722 naftopidil 47.16 µM -1.33107896518307 0.0887657701733399 no 3050 0.0915815147431867 4315 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_3235 9132602 49.47 µM -1.33245022218574 0.0885407216260817 no 3051 0.0913561441384655 4385 4912240 SGTC_1432 4049-0298 68.4 µM -1.3391211429574 0.0874519614157939 no 3052 0.0902656192565925 4409 741646 SGTC_1724 st037281 8.293 µM -1.33973546497692 0.0873522026824481 no 3053 0.0901656815916587 4365 574124 YDL195W SEC31 SGTC_1836 st055642 81 µM -1.34428653799948 0.0866158058418941 no 3054 0.0894278735332772 4391 8571 SGTC_2094 5332512 191.667 µM -1.34727571083911 0.0861346668126494 no 3055 0.0889457259111164 4426 755774 SGTC_1292 0kpi-0043 232 µM -1.34752198110315 0.0860951163296534 no 3056 0.0889060894586779 4423 3333905 SGTC_2869 9037858 32.47 µM -1.34757182160944 0.0860871137031765 no 3057 0.0888980693804658 4369 27187042 SGTC_2894 9048625 32.47 µM -1.34792293663019 0.086030752790371 no 3058 0.0888415850176087 4422 4092861 SGTC_1195 1502-0147 41.1 µM -1.34933617673518 0.0858041789547654 no 3059 0.0886145053332526 4383 817940 SGTC_3284 9108171 64.8615 µM -1.35242169045654 0.0853110550162084 no 3060 0.088120227244158 4379 8687505 SGTC_1581 himbacine 57.9 µM -1.35444995597008 0.0849880579659994 no 3061 0.0877964345022714 4408 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1833 st055984 71 µM -1.35460442038452 0.0849634974438411 no 3062 0.0877718121844931 4414 676288 SGTC_1751 st044839 27.194 µM -1.35472147519762 0.0849448887569872 no 3063 0.0877531565553868 4449 5291326 SGTC_328 k915-0120 63.5 µM -1.35570604551415 0.0847884884579494 no 3064 0.0875963575677361 4415 6624543 SGTC_1624 st003710 6.25 µM -1.35807469970795 0.0844131093288903 no 3065 0.0872199911651295 4445 24207033 SGTC_1233 0325-0408 14.2 µM -1.35856985621339 0.0843347958308626 no 3066 0.0871414662742957 4446 12874 SGTC_3227 9130768 49.47 µM -1.35924018124118 0.0842288647219177 no 3067 0.0870352462367409 4472 17720899 SGTC_122 0236-0016 402.397 µM -1.36023995799346 0.0840710561301694 no 3068 0.0868770008387415 4401 6808838 SGTC_776 4476-4378 112 µM -1.36025551780295 0.0840686018656632 no 3069 0.0868745397205704 4458 2892008 SGTC_3014 9081533 49.47 µM -1.36264282005094 0.0836926871684909 no 3070 0.086497553366552 4439 21367265 SGTC_1689 st020265 53.493 µM -1.36430399160454 0.0834318580962317 no 3071 0.0862359550749543 4409 5758320 YPR016C TIF6 SGTC_560 2332-1943 155 µM -1.36652729853448 0.0830837219406212 no 3072 0.0858867593164742 4410 21177716 SGTC_3273 9137859 49.47 µM -1.3675944137428 0.0829170163977031 no 3073 0.0857195330080419 4490 2377234 SGTC_1286 0929-0070 131 µM -1.36947019972873 0.0826245897966799 no 3074 0.0854261719000843 4482 1420408 SGTC_2267 7931562 200 µM -1.37225153280654 0.0821924221886533 no 3075 0.0849925739991858 4371 934880 SGTC_2997 9067075 71.4286 µM -1.37227290747778 0.0821891075662311 no 3076 0.0849892481790515 4380 27209819 SGTC_728 3030-5151 22.5 µM -1.37233595966667 0.0821793304960175 no 3077 0.0849794380589499 4495 3125388 SGTC_2446 5162541 200 µM -1.37611842696297 0.0815944105662592 no 3078 0.0843924857291774 4394 1549321 SGTC_1036 k216-0215 33.5 µM -1.38105606664344 0.0808355855523345 no 3079 0.0836308612067184 4366 622330 SGTC_1996 st072960 66.8 µM -1.38397995454425 0.0803887560196029 no 3080 0.0831822963634436 4451 1719405 SGTC_3232 9132874 49.47 µM -1.3850345196607 0.0802280557759006 no 3081 0.0830209561740284 4393 3784940 SGTC_1920 st075728 45.7 µM -1.3865116627057 0.0800033692441186 no 3082 0.0827953607701521 4403 3400306 SGTC_2497 7-hydroxyflavone 100 µM -1.38704473004541 0.0799224019181526 no 3083 0.0827140618810841 4439 5281894 SGTC_7 0192-1582 4.227 µM -1.39574597382211 0.0786095203034416 no 3084 0.0813955023385878 4482 252616 SGTC_2788 5282734 71.43 µM -1.39686706258573 0.0784415611717032 no 3085 0.0812267754822687 4452 743706 SGTC_231 b-estradiol 524 µM -1.40172024143047 0.0777176052765711 no 3086 0.0804994018767405 4415 450 A steroid. SGTC_356 1634-0012 32.5 µM -1.40274734380386 0.0775650432401962 no 3087 0.0803460970008405 4432 735457 SGTC_2789 5281112 71.43 µM -1.40361690227864 0.0774360600444718 no 3088 0.080216479599478 4431 765948 SGTC_2143 5623677 140.463 µM -1.40398183477416 0.0773819774940418 no 3089 0.080162129440897 4384 5375313 SGTC_417 st075190 100 µM -1.4088621581547 0.0766614742359214 no 3090 0.0794379655144735 4428 222757 SGTC_233 rapamycin 362 pM -1.41150857772558 0.0762729112062975 no 3091 0.0790473540888833 4440 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1062 mesoridazine 14.2 µM -1.41288024104566 0.0760721060948184 no 3092 0.0788454698608739 4487 4078 A neuroleptic. SGTC_636 0kpi-0074 126 µM -1.41377843827463 0.0759408324301737 no 3093 0.0787134831470441 4441 616434 SGTC_1272 0839-0021 27 µM -1.41873630515067 0.0752193303433831 no 3094 0.077987954260677 4479 5027250 SGTC_189 3970-0742 2.116 µM -1.42261846857928 0.0746580294639657 no 3095 0.0774233935929611 4425 2891807 SGTC_688 0527-0193 473 µM -1.42824130345493 0.0738507295889865 no 3096 0.0766112079908268 4496 4007154 SGTC_337 1315-0038 354 µM -1.42949611975638 0.0736714829347406 no 3097 0.0764308446989416 4430 1626437 SGTC_2322 7413319 38.22 µM -1.42997446154112 0.0736032409058091 no 3098 0.0763621744887231 4410 1840400 SGTC_1273 0849-0096 14.1 µM -1.43025370796318 0.0735634249148945 no 3099 0.0763221078936053 4470 5286025 SGTC_983 1491-0821 12.2 µM -1.43398705110128 0.0730326916868086 no 3100 0.0757879790546618 4453 46495113 SGTC_474 dl-dihydrosphingosine 5 µM -1.43851648689598 0.0723927259653696 no 3101 0.0751437814842357 4452 3058739 A sphingolipid protein kinase C inhibitor. SGTC_506 n9-isopropylolomoucine 153 µM -1.43902773797153 0.0723207618025136 no 3102 0.0750713319895691 4450 6610355 SGTC_3280 9140961 49.47 µM -1.43962611695491 0.0722366030787643 no 3103 0.0749866032558325 4491 4901226 SGTC_1565 sinapyl alcohol 95.1 µM -1.43972297538804 0.0722229875318438 no 3104 0.0749728952431675 4467 5280507 A phenol propionate derived from cinnamic acid. SGTC_6 0844-0013 19.835 µM -1.44924083034686 0.070894616535651 no 3105 0.0736351693360496 4588 1584900 SGTC_2121 5257820 149.641 µM -1.449624395764 0.070841479844533 no 3106 0.0735816445836196 4495 791256 SGTC_1922 5578187 25 µM -1.44989364308557 0.0708041983299337 no 3107 0.0735440901579806 4466 1350412 SGTC_1421 4029-0249 71.4 µM -1.45115065179514 0.0706303451973508 no 3108 0.0733689573783806 4539 2894095 SGTC_1654 st012436 41.8 µM -1.45123475924781 0.0706187242667142 no 3109 0.0733572505006114 4460 4323132 SGTC_2043 5101342 149 µM -1.45669873380067 0.0698669238279288 no 3110 0.072599779732573 4491 678451 SGTC_2170 morpholine 200 µM -1.45712257987281 0.0698088643162365 no 3111 0.072541273253815 4503 121171 Reacts with secondary amines. SGTC_1674 st016616 23.6 µM -1.46222191977719 0.0691132515317264 no 3112 0.0718402033983891 4420 625830 SGTC_1698 5-fluorocytosine 1.055 µM -1.46271814920304 0.069045845921066 no 3113 0.0717722589422784 4489 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_608 k048-0125 159 µM -1.46416386681578 0.0688497548475613 no 3114 0.0715745901489025 4521 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2889 9059656 51.95 µM -1.46991476809543 0.0680739752357846 no 3115 0.0707924196540531 4548 3949838 SGTC_760 0568-0725 82.9 µM -1.47129402509367 0.0678889246617309 no 3116 0.0706058092319687 4491 3916171 SGTC_2177 5811945 192 µM -1.47305461622048 0.0676532764010098 no 3117 0.070368154740711 4492 5343475 SGTC_134 0269-0018 6.916 µM -1.47829945805442 0.0669550193750392 no 3118 0.0696638213415693 4432 4378915 SGTC_3281 9140613 49.47 µM -1.47833794963899 0.0669499155927418 no 3119 0.0696586724163036 4462 16013766 SGTC_352 k048-0007 5.11 µM -1.47961258957501 0.066781074949253 no 3120 0.0694883323825763 4418 6811911 SGTC_802 4112-3352 742 µM -1.47972805680153 0.0667657962832713 no 3121 0.0694729174594953 4507 704594 SGTC_1688 st021091 57.6 µM -1.48120979436311 0.0665699722018187 no 3122 0.0692753385270932 4510 3656366 SGTC_2282 7944268 200 µM -1.48254238279607 0.0663942394024688 no 3123 0.0690980175173428 4470 2970414 SGTC_653 0203-0016 55.2 µM -1.483073354473 0.0663243185857713 no 3124 0.0690274612454767 4554 295302 SGTC_252 miconazole 1.30953 nM -1.48507413573663 0.0660613585767459 no 3125 0.0687620933250649 4401 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1942 st076330 65.2 µM -1.49087082361577 0.0653040667606105 no 3126 0.0679977064098345 4538 24208414 SGTC_172 1112-0046 2.638 µM -1.49264844145729 0.0650731892799042 no 3127 0.0677646180325754 4471 2802135 YIL048W NEO1 SGTC_2812 7970281 58.44 µM -1.49666764568345 0.0645535096776912 no 3128 0.0672398794649677 4509 2233435 SGTC_1557 sumaresinolic acid 42.3 µM -1.49757983901665 0.0644360139636247 no 3129 0.0671212240386513 4461 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1981 st071826 47 µM -1.4998591553765 0.0641431513072536 no 3130 0.0668254450528819 4532 11838600 SGTC_789 1309-1135 70.6 µM -1.50133085938168 0.0639546068148412 no 3131 0.0666350035478314 4478 3092424 SGTC_852 0418-0143 439 µM -1.50149400472808 0.0639337323298395 no 3132 0.0666139180958779 4482 5369229 SGTC_2939 9044578 71.43 µM -1.50423258282421 0.0635841210325458 no 3133 0.066260745477303 4428 2653634 SGTC_3233 9132340 49.47 µM -1.50587009880134 0.0633757849024906 no 3134 0.0660502619145482 4512 17682950 SGTC_1525 8-methoxypsoralen 92.5 µM -1.50633307538018 0.063316978273017 no 3135 0.0659908457125578 4521 4114 Related to psoralen; DNA damaging agent. SGTC_2273 7815444 169.05 µM -1.51420228148465 0.0623239271585624 no 3136 0.0649872716179992 4441 2824616 SGTC_1294 1000-1494 117 µM -1.52209831974349 0.0613397408903671 no 3137 0.0639922234807163 4507 712797 YDL207W GLE1 SGTC_701 4424-0219 185 µM -1.52376051793404 0.0611341147963084 no 3138 0.0637842728232529 4523 2911779 SGTC_3275 9138069 49.47 µM -1.52474803435353 0.0610122071183096 no 3139 0.0636609779172626 4556 17617007 SGTC_830 4076-0286 57.8 µM -1.52540258903105 0.0609315079327855 no 3140 0.0635793566986606 4559 6866659 SGTC_1287 0971-0001 34.6 µM -1.52588442397295 0.0608721564791157 no 3141 0.0635193252219579 4492 4665869 SGTC_918 glabranin 770.725 nM -1.52838907204774 0.0605643668935607 no 3142 0.0632079832158707 4521 124049 Also referred to as licorice root. SGTC_1114 scopoletin 1.73284 µM -1.53113030161153 0.0602289013229383 no 3143 0.0628685961031513 4538 5280460 A coumarin with genotoxic properties. SGTC_114 0364-0001 490.298 µM -1.53510131395782 0.0597455195170275 no 3144 0.0623794718007607 4519 4003655 SGTC_2544 sphondin 68.51 µM -1.53517484679219 0.0597365972888418 no 3145 0.0623704425532051 4476 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2413 inermin 26.06 µM -1.54048058015252 0.0590955680850346 no 3146 0.0617216264577325 4541 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_3288 9119690 36.221 µM -1.544455249938 0.058618900267639 no 3147 0.061239042123737 4508 17595618 YKL019W RAM2 SGTC_2416 tofa 880 nM -1.55440929551484 0.0574383903239687 no 3148 0.0600434086781393 4469 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_629 3448-6466 76.7 µM -1.55552018993141 0.0573078111538902 no 3149 0.0599111149564772 4536 573744 SGTC_1748 st037455 53.6035 µM -1.55609882190022 0.0572398889198598 no 3150 0.0598422975633353 4532 580690 SGTC_2718 lomofungin 53.02 µM -1.55858288469243 0.0569490188069088 no 3151 0.0595475682692193 4503 5351222 A RNA synthesis inhibitor. SGTC_2731 amoxapine 43.43 µM -1.56319899412573 0.0564115898585794 no 3152 0.0590028983300412 4688 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_14 0354-0009 295 µM -1.56538642690931 0.0561583185753499 no 3153 0.0587461645164263 4618 1713507 SGTC_1182 1222-0449 220 µM -1.57948602784952 0.054547253188805 no 3154 0.0571123094163217 4539 658318 SGTC_1714 st033236 13.627 µM -1.57997314245202 0.0544922540424367 no 3155 0.0570565086211716 4531 2916566 SGTC_1652 st011932 78 µM -1.58022551521219 0.0544637763863924 no 3156 0.0570276152635723 4466 1551076 SGTC_1118 chelidonine 707.474 nM -1.58682673468702 0.0537230693115225 no 3157 0.0562759460213885 4532 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2261 9010538 184.68 µM -1.58718966325118 0.0536825784886666 no 3158 0.0562348475887573 4511 6457250 SGTC_357 1325-0123 420 µM -1.58819702111274 0.0535703173241665 no 3159 0.0561208972577852 4533 1098503 SGTC_2360 9040895 200 µM -1.59232691964102 0.0531120195259407 no 3160 0.0556556336690984 4559 4914414 SGTC_2361 9034121 116 µM -1.59301874503489 0.0530355520621158 no 3161 0.0555779929729377 4560 6496917 SGTC_127 0180-0333 59.125 µM -1.5956506627102 0.0527454437315468 no 3162 0.0552834048016593 4453 771601 SGTC_51 1013-0126 23.419 µM -1.59660316262512 0.0526407633619157 no 3163 0.0551770967547674 4534 1627850 SGTC_2431 5490079 200 µM -1.6008959569711 0.0521710268166168 no 3164 0.0546999826161173 4569 5722345 SGTC_411 enrofloxacin 100 µM -1.6017798047625 0.052074726822625 no 3165 0.054602155198694 4573 71188 A bacterial gyrase inhibitor. SGTC_1334 1486-0610 236 µM -1.60286098729861 0.051957118219096 no 3166 0.0544826742564741 4609 3742339 SGTC_1376 2910-0861 41.3 µM -1.60732378171462 0.0514738973833659 no 3167 0.0539916800182251 4481 1112859 SGTC_406 estrone 100 µM -1.60760609770423 0.0514434494768151 no 3168 0.0539607379502851 4548 5870 A steroid. SGTC_1605 st000082 49.1 µM -1.60852015133929 0.0513449666365579 no 3169 0.0538606532062763 4506 1114022 SGTC_851 0394-0702 453 µM -1.61743128327316 0.0503926940720757 no 3170 0.0528926087741653 4563 762646 SGTC_2181 6316240 54.2555 µM -1.61860175222182 0.0502686664334931 no 3171 0.0527664889309401 4579 12779990 SGTC_2993 9054257 71.4286 µM -1.62478256429821 0.0496177520144494 no 3172 0.0521044487311363 4475 6470217 YGL055W OLE1 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.6258961781043 0.0495011932239157 no 3173 0.0519858716523457 4497 6708514 SGTC_2019 4016004 108 µM -1.6263210293299 0.0494567828882011 no 3174 0.0519406902326414 4567 45595336 SGTC_108 0509-0257 621.132 µM -1.63646106445379 0.0484062368072141 no 3175 0.050871564039684 4534 536624 SGTC_3256 9138902 49.47 µM -1.63695279072193 0.0483557493536651 no 3176 0.0508201670863842 4667 17228773 SGTC_874 0599-0792 117 µM -1.63894530592881 0.0481516010190455 no 3177 0.0506123254875693 4557 765305 SGTC_2552 juarezic acid 87.02 µM -1.64905332527348 0.0471265585068657 no 3178 0.0495683552885671 4522 1549512 SGTC_295 k015-0027 31 µM -1.65238427632842 0.0467926286667381 no 3179 0.0492281194129714 4615 3887424 SGTC_3243 9134147 49.47 µM -1.65889545492387 0.0461453619004309 no 3180 0.0485684303397653 4660 24282180 SGTC_1755 st041960 45.185 µM -1.66373735615776 0.0456687131801654 no 3181 0.048082463774478 4588 2257073 SGTC_3228 9131799 49.47 µM -1.66512581423613 0.0455327625642475 no 3182 0.0479438287894182 4594 17015818 SGTC_1851 st056236 18.9 µM -1.67079110978571 0.0449814155719726 no 3183 0.0473814725777179 4542 5393171 SGTC_682 0kpi-0099 17 µM -1.67868344431501 0.0442223042773024 no 3184 0.046606877097684 4583 1714895 YML126C ERG13 SGTC_1897 st060201 15 µM -1.68020319166823 0.0440773223297785 no 3185 0.0464588942907199 4579 611878 SGTC_2713 st079149 53.4 µM -1.68876938904462 0.0432672716224205 no 3186 0.0456318160872202 4600 3103253 SGTC_3147 9097027 49.47 µM -1.69041651451851 0.0431129000798236 no 3187 0.0454741488977534 4584 25236841 SGTC_1423 4048-0112 5.59 µM -1.69150187291462 0.0430114217430093 no 3188 0.0453704951919723 4630 X1423 SGTC_1416 3966-0321 25.3 µM -1.69406949047052 0.042772124004912 no 3189 0.0451260395121021 4637 582530 YLR208W SEC13 SGTC_2229 7354935 190 µM -1.69697812754043 0.0425023450422353 no 3190 0.0448503978975829 4583 318112 SGTC_2510 benzyl isothiocyanate 8.31 µM -1.70030538689124 0.0421954276565642 no 3191 0.0445367488577919 4611 2346 DNA damaging agent; causes G2/M arrest. SGTC_2218 6965428 192.983 µM -1.71459618067325 0.0408975319692056 no 3192 0.0432096447385647 4512 675684 SGTC_2893 9048488 25.97 µM -1.71728393746845 0.0406570850323374 no 3193 0.0429636527106668 4626 6467338 SGTC_190 3970-0790 3.722 µM -1.71835651825795 0.0405614527097469 no 3194 0.0428658031338661 4559 2832352 SGTC_1571 st070080 73.4 µM -1.72251806094816 0.0401921328709285 no 3195 0.0424878569665992 4587 4315245 SGTC_2154 5570129 200 µM -1.72575453759196 0.0399068010890796 no 3196 0.0421957909386018 4649 673366 SGTC_1817 st052116 64.4 µM -1.73182932288379 0.0393756865904554 no 3197 0.0416519778066819 4623 4361398 SGTC_546 peri-Naphthalide 147 µM -1.73189328890834 0.0393701248313803 no 3198 0.0416462819343986 4567 223824 A penicillin ester. SGTC_1811 st050069 61.5 µM -1.73602118690736 0.0390125590523553 no 3199 0.0412800442119976 4607 3877702 SGTC_438 sphingosine 6.67 µM -1.73832060628043 0.0388145287606537 no 3200 0.0410771687155504 4547 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2734 clemastine 41.6 µM -1.73869170901341 0.0387826455656627 no 3201 0.041044502591444 4669 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2526 patulin 37.61 µM -1.7442948007567 0.0383038448974095 no 3202 0.0405538488986774 4594 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1856 st057054 55.7 µM -1.74566959867972 0.0381871036867512 no 3203 0.0404341903542801 4577 1266018 SGTC_1990 st072050 59.8 µM -1.74743530962326 0.0380375938472511 no 3204 0.0402809285367279 4601 17233948 SGTC_22 0964-0034 14.468 µM -1.75173538360062 0.0376754861218802 no 3205 0.0399096598149989 4613 138402 SGTC_2348 9022543 33.42 µM -1.75662126834755 0.0372674678672746 no 3206 0.0394911926632962 4614 3162678 YDL140C RPO21 SGTC_2251 lansoprazole 556 µM -1.7610967477783 0.0368968972364987 no 3207 0.0391110146993484 4594 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1784 st039334 36.3 µM -1.76132150575089 0.0368783669630877 no 3208 0.0390920010554198 4614 3496984 SGTC_132 0417-1715 25.805 µM -1.76279262764241 0.0367572674631814 no 3209 0.0389677356451436 4583 6769098 SGTC_168 3970-0862 530.542 µM -1.76628692862004 0.0364709276735943 no 3210 0.0386738617180203 4532 3135186 SGTC_133 0724-0033 378.92 µM -1.77127044320407 0.0360657149867985 no 3211 0.038257870017054 4542 280309 SGTC_582 0987-0078 156 µM -1.7733348028358 0.0358989441310191 no 3212 0.0380866226837978 4648 1625765 SGTC_698 k064-0052 127 µM -1.77381635521209 0.0358601325688748 no 3213 0.0380467659518591 4688 5088751 SGTC_171 k064-0041 9.68 µM -1.77864376845084 0.0354729552821525 no 3214 0.0376490917885392 4595 53325 SGTC_1810 st050138 53 µM -1.7791209883207 0.0354348672714551 no 3215 0.0376099642097961 4626 3444541 SGTC_1356 1502-0781 85.8 µM -1.78611367483954 0.0348806007757128 no 3216 0.0370404272228645 4632 567702 SGTC_2653 dihydrofissinolide 100 µM -1.78716489818194 0.0347978955759792 no 3217 0.0369554204060877 4699 6857746 SGTC_285 1486-1325 46 µM -1.78835845631127 0.0347041874170342 no 3218 0.03685909714485 4644 22310230 SGTC_102 gallobenzophenone 83.616 µM -1.79012624225214 0.0345657765674677 no 3219 0.0367168094791911 4605 70837 SGTC_3198 9112019 49.47 µM -1.79258474643243 0.0343740392770712 no 3220 0.0365196736150447 4654 45595555 SGTC_2513 baicalein 25.65 µM -1.80047410705081 0.0337646471016871 no 3221 0.0358929042546685 4602 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_723 4182-0001 115 µM -1.80252194313879 0.0336079289716581 no 3222 0.0357316627548919 4620 744821 YLR208W SEC13 SGTC_3350 9150499 3.57 µM -1.8102642051814 0.0330208255327722 no 3223 0.0351274125689764 4625 4910996 YPR165W RHO1 SGTC_2989 9073649 71.4286 µM -1.81143625084011 0.0329326891035537 no 3224 0.035036674385918 4581 21367202 SGTC_1385 3091-4834 14.1 µM -1.82123666438233 0.0322032732764135 no 3225 0.0342854446843239 4627 4072814 SGTC_815 1582-0027 36.9 µM -1.82221714668174 0.0321310384260815 no 3226 0.034211021932933 4642 3128206 SGTC_3189 9110682 49.47 µM -1.8269443948324 0.031784643693168 no 3227 0.0338540651683612 4624 17122418 SGTC_2727 riluzole 51.77 µM -1.82749637221362 0.0317443987986726 no 3228 0.0338125855824324 4667 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1618 st003135 44.5 µM -1.82910866709465 0.0316270867550095 no 3229 0.0336916654211307 4626 1270615 SGTC_2515 chrysin 20.77 µM -1.85037670792111 0.030112864665365 no 3230 0.0321296368447075 4652 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1847 st056231 15 µM -1.8505555028331 0.0301003943523165 no 3231 0.0321167631189373 4627 5393180 SGTC_1090 efavirenz 20.7 µM -1.85142641178852 0.0300397127365779 no 3232 0.032054116154714 4658 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2219 9098279 200 µM -1.85442528143728 0.029831538436939 no 3233 0.0318391703350114 4611 902349 SGTC_1545 lovastatin 49.4 µM -1.86463322307974 0.0291318785237481 no 3234 0.0311164163411527 4670 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2721 ifenprodil 61.44 µM -1.87106920446194 0.0286977992185064 no 3235 0.0306677447042349 4616 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2652 actinonin 100 µM -1.88219374404172 0.0279601839604626 no 3236 0.0299048573805519 4700 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2047 4141938 200 µM -1.88657968486469 0.0276737457983529 no 3237 0.0296084406602139 4670 3807862 SGTC_1024 4507-0395 26 µM -1.88746641792014 0.027616133009555 no 3238 0.0295488095430835 4672 4201836 SGTC_2165 5727197 32.143 µM -1.89156027421668 0.0273514418246631 no 3239 0.0292747965339685 4655 1361712 SGTC_2709 st078560 56 µM -1.89577414389791 0.0270812042712843 no 3240 0.0289949581323682 4627 17250903 SGTC_511 blebbistatin 171 µM -1.90338574937756 0.0265987155479422 no 3241 0.0284951145695952 4674 3476986 A myosin inhibitor. SGTC_2447 5741742 33.78 µM -1.90505697218668 0.0264937461780303 no 3242 0.0283863328681023 4692 1776504 SGTC_3158 9100007 49.47 µM -1.90540533071164 0.0264719094587255 no 3243 0.0283637014119553 4665 19297233 SGTC_642 0335-0876 158 µM -1.90802064007873 0.026308449638183 no 3244 0.0281942743217686 4696 6812350 SGTC_2006 4011487 200 µM -1.91225255507431 0.0260457377517972 no 3245 0.027921904053838 4601 45595294 SGTC_1255 0566-0045 221 µM -1.91817427191495 0.0256818115241113 no 3246 0.0275444586818766 4651 2788469 SGTC_1583 clindamycin 39.6 µM -1.92365073986208 0.0253490466413213 no 3247 0.0271991882268467 4659 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_562 3772-2733 112 µM -1.92538899785948 0.0252441835847961 no 3248 0.0270903554894687 4641 2876874 YIL048W NEO1 SGTC_786 4544-0069 423 µM -1.92838882449347 0.0250640694429395 no 3249 0.0269033904165978 4652 748821 YLR208W SEC13 SGTC_2823 7987624 58.44 µM -1.93110191893963 0.0249021000507617 no 3250 0.0267352248807191 4597 2239440 SGTC_612 0302-0167 22.4 µM -1.93669790332649 0.0245707957391033 no 3251 0.0263911411075201 4653 235821 SGTC_2409 alverine citrate 63.97 µM -1.94678191863443 0.0239831200554896 no 3252 0.0257804427992871 4644 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2769 toremifene 3.73 µM -1.95104936186613 0.0237380032079667 no 3253 0.0255255870602495 4657 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1136 pergolide 1.05886 µM -1.95135383148186 0.0237205956314337 no 3254 0.025507484761368 4616 47811 A dopamine receptor agonist. SGTC_98 0074-0023 107.663 µM -1.95785892138655 0.0233512340109145 no 3255 0.0251232846239146 4676 3563821 SGTC_12 0849-0099 9.267 µM -1.97426208321311 0.0224412918063239 no 3256 0.0241759749639842 4664 6071388 SGTC_965 1291-5240 308 µM -1.97627581397121 0.0223316718697304 no 3257 0.0240617736701592 4666 2834598 SGTC_477 mead ethanolamide 10 µM -1.97818900887198 0.0222279435075869 no 3258 0.0239536940961016 4699 16061185 SGTC_2075 5212009 200 µM -1.97836020937542 0.0222186813187731 no 3259 0.0239440426123504 4641 780898 SGTC_2929 9013348 24.6 µM -1.98089192278001 0.0220820917785423 no 3260 0.0238016975462034 4648 2995952 SGTC_1911 st060208 74.3 µM -1.98305621855489 0.0219658875169845 no 3261 0.023680575129769 4681 688783 SGTC_71 0417-1750 47.813 µM -1.98816981511189 0.0216933804852038 no 3262 0.0233964560601714 4634 6811472 SGTC_1644 st010134 20.9 µM -1.98895338675926 0.0216518768396797 no 3263 0.0233531741216007 4675 3818134 SGTC_1206 3978-0017 132 µM -2.02052045040152 0.0200347799101235 no 3264 0.0216647155332824 4665 3873677 SGTC_2895 9054447 58.44 µM -2.03282406155071 0.0194328536227024 no 3265 0.0210351506386187 4727 2697450 SGTC_1305 1181-0477 144 µM -2.03534020780087 0.0193116677010361 no 3266 0.0209083265530418 4713 6252086 SGTC_2553 4-methylesculetin 85.09 µM -2.03537266136227 0.019310108834912 no 3267 0.0209066949977178 4678 5319502 SGTC_2380 9035439 200 µM -2.03769682287419 0.0191987483549665 no 3268 0.0207901310639461 4718 6462575 SGTC_883 0850-0245 24.6 µM -2.04033505192583 0.0190730015608398 no 3269 0.0206584829521393 4711 6823229 YPR165W RHO1 SGTC_2603 homopterocarpin 100 µM -2.04094146295841 0.0190441971813266 no 3270 0.0206283229294894 4669 101795 A weak amylase inhibitor. SGTC_2697 mebhydrolin 72.4 µM -2.04248867511245 0.0189708725197027 no 3271 0.020551540828615 4692 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2838 9002687 71.43 µM -2.04444566587941 0.0188784719000246 no 3272 0.0204547699426179 4672 6457060 SGTC_3236 9132701 49.47 µM -2.05312990991863 0.0184730452370053 no 3273 0.0200299899173598 4713 24282524 SGTC_86 0417-1630 471.922 µM -2.05649988594997 0.0183177260145362 no 3274 0.0198671786322317 4714 3634867 SGTC_735 3076-0345 636 µM -2.07556554343053 0.0174598049382853 no 3275 0.0189670755090557 4689 2888990 SGTC_2966 9084041 48.03 µM -2.08124519064368 0.0172109589819372 no 3276 0.018705734554671 4661 17741380 SGTC_450 aminopyrene 156 nM -2.08685034212792 0.0169683541773659 no 3277 0.0184508324268994 4678 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_841 0251-0215 91.2 µM -2.09490012681831 0.0166250575528536 no 3278 0.0180899357979916 4732 3888614 SGTC_1928 4'-methoxychalcone 40.3 µM -2.10504093535736 0.016201060223002 no 3279 0.0176438724520274 4691 641818 SGTC_1601 4'-hydroxyflavanone 55.5 µM -2.10883539899103 0.0160448089910412 no 3280 0.0174793959599475 4717 165506 SGTC_782 0083-0095 30.5 µM -2.12516680603273 0.0153869596439354 no 3281 0.016786348369712 4703 3591729 An indicator and reagent. SGTC_710 3448-4187 58 µM -2.12694167770326 0.0153168807842647 no 3282 0.0167124646863455 4685 3946412 SGTC_493 zm226600 134 µM -2.1322707383639 0.0151081133399757 no 3283 0.0164922980682528 4705 5240098 A potassium channel opener. YCR052W RSC6 SGTC_322 k048-0136 19.3 µM -2.13831243036858 0.0148743902212468 no 3284 0.0162456971806136 4738 6823282 SGTC_1980 st071811 45.7 µM -2.13906806421341 0.0148453783798248 no 3285 0.016215078187956 4741 4974850 SGTC_2975 9084847 53.72 µM -2.14686295510902 0.0145489300975375 no 3286 0.01590209678973 4681 27211724 SGTC_1311 1190-0148 100 µM -2.14987408212976 0.014435785461567 no 3287 0.015782588122252 4725 1961333 SGTC_1955 wogonin 32.4 µM -2.15052603319464 0.0144113880775919 no 3288 0.015756814517613 4682 5281703 A flavanone. SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -2.15234656996545 0.0143434476467067 no 3289 0.0156850342543295 4728 1609 A potent and irreversible inhibitor of serine proteases. SGTC_620 0109-0052 432 µM -2.16366446996062 0.0139272329484915 no 3290 0.0152450548600537 4734 493037 SGTC_868 0527-0199 213 µM -2.17733238284734 0.0134385139949772 no 3291 0.0147278883549707 4705 2849450 SGTC_3009 9080819 71.4286 µM -2.18349904072484 0.0132229076197673 no 3292 0.0144995397628199 4728 17027216 SGTC_440 fluspirilene 35.1 µM -2.18676162244602 0.0131100508017858 no 3293 0.0143799652209867 4707 3396 An atypical antipsychotic. SGTC_180 1486-1293 102.781 µM -2.19417610692332 0.0128566659120363 no 3294 0.0141113757802455 4670 4140536 SGTC_1344 1488-0097 29.1 µM -2.21195287839824 0.0122663460272433 no 3295 0.0134849605009901 4743 747966 SGTC_686 1319-0111 510 µM -2.23173913638076 0.0116370511751146 no 3296 0.0128161045120128 4725 4562600 SGTC_3278 9139605 49.47 µM -2.23845522065398 0.0114299157599157 no 3297 0.0125956922207343 4705 7958859 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -2.2619825212328 0.0107293526616277 no 3298 0.0118492416119916 4717 5377381 SGTC_1861 st057647 17.4 µM -2.27527485796426 0.0103503213742878 no 3299 0.0114447233466883 4733 688668 SGTC_2760 etidronate 98.04 µM -2.29396275044793 0.00983720063990068 no 3300 0.0108963192285661 4697 3305 A chelator and antioxidant. SGTC_37 0566-0070 1.56 µM -2.30042784501515 0.00966493233362958 no 3301 0.0107119964012961 4702 1626686 SGTC_104 0074-0074 590.992 µM -2.30851364348891 0.00945319357241563 no 3302 0.0104852924400276 4708 3943124 SGTC_2846 9008642 19.48 µM -2.30990928128719 0.00941706016258965 no 3303 0.010446588561234 4721 2992898 SGTC_552 k242-0005 476 µM -2.32978550610626 0.00891541891623677 no 3304 0.00990874529555931 4761 4088318 SGTC_2493 resveratrol 26.09 µM -2.33143010788267 0.00887498058962692 no 3305 0.00986534574245526 4738 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_278 4092-0821 23.9 µM -2.33159914346543 0.00887083337783156 no 3306 0.00986089446782543 4717 877900 SGTC_1965 Pectolinarigenin 58.4 µM -2.34521090224539 0.00854240042864675 no 3307 0.0095081597562558 4730 5320438 An anti-inflammatory. SGTC_2792 7535235 81.82 µM -2.36302187729768 0.00812878833679906 no 3308 0.00906329975306169 4698 1281891 SGTC_670 4204-0025 119 µM -2.3709215538482 0.00795104452571754 no 3309 0.00887189831779141 4734 719039 SGTC_462 ag-879 158 µM -2.37743733846142 0.00780701971334598 no 3310 0.00871670236005911 4749 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2849 9019321 12.99 µM -2.39539743310312 0.00742184684531043 no 3311 0.00830117926009504 4735 16489627 SGTC_2973 9094665 17.96 µM -2.40002885211872 0.00732527824818874 no 3312 0.00819688981731963 4716 25237061 YIL048W NEO1 SGTC_2190 6049624 200 µM -2.40748743213148 0.00717208842063958 no 3313 0.00803135752967507 4722 2265554 SGTC_3211 9128781 49.47 µM -2.41474463073957 0.00702575415941737 no 3314 0.00787312258219551 4671 17194361 SGTC_3109 9122853 49.47 µM -2.50979798501949 0.00533856091301307 no 3315 0.00604001233558767 4774 1234709 SGTC_2313 7726885 200 µM -2.51851754077821 0.00520350651114955 no 3316 0.00589250066940795 4749 726423 SGTC_1360 1598-0022 39.8 µM -2.53859289895809 0.00490405854755537 no 3317 0.00556496247715964 4774 761525 SGTC_358 0075-0058 9.45 µM -2.55238930949764 0.00470726970658214 no 3318 0.00534934494062552 4725 1069125 SGTC_458 nppb 133 µM -2.575515121093 0.00439316637715469 no 3319 0.00500454483627653 4782 4549 A chloride channel blocker. SGTC_2124 5246320 200 µM -2.57944241182138 0.00434172540918967 no 3320 0.0049479978570839 4767 579342 SGTC_487 nimodipine 119 µM -2.60638241195893 0.00400313401205916 no 3321 0.00457521183360127 4787 4497 L-type voltage-gated calcium channels inhibitor SGTC_3072 9116419 49.47 µM -2.60712129686374 0.00399419015419713 no 3322 0.004565350453311 4754 17170162 SGTC_478 N-arachidonylglycine 10 µM -2.63320756755273 0.00368967543545817 no 3323 0.0042291319150896 4793 5283389 SGTC_1790 st045711 43.5 µM -2.64149218421707 0.003597419206455 no 3324 0.00412708558010461 4775 585119 SGTC_1023 4482-3888 16 µM -2.64706303899975 0.00353655271695945 no 3325 0.00405971078725087 4761 3303168 SGTC_1621 st003705 32.4 µM -2.64804786119043 0.0035258893650743 no 3326 0.0040479031341774 4771 24207032 SGTC_1978 st071761 42 µM -2.67534199887553 0.00324161211827208 no 3327 0.0037326526243069 4772 5147680 SGTC_475 α-linolenic acid 10 µM -2.67673183081315 0.00322770432188911 no 3328 0.00371720564780538 4775 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3291 9121177 71.43 µM -2.69457447277014 0.00305386409170413 no 3329 0.00352392873596872 4755 17015612 SGTC_2630 antimycin a 100 µM -2.69511299166263 0.00304875097414424 no 3330 0.00351823826650538 4737 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_3356 9151811 4.48 µM -2.71327007963747 0.00288080322176075 no 3331 0.00333113914587891 4790 1859254 YPR165W RHO1 SGTC_2844 9010103 25.97 µM -2.75053391138004 0.00256199396849225 no 3332 0.00297491164134356 4738 2480525 SGTC_2947 9072639 7.68 µM -2.75083866913329 0.00255952359878626 no 3333 0.00297214553364817 4737 16488146 SGTC_1308 1187-1617 41.4 µM -2.75284432465866 0.00254331936935488 no 3334 0.00295399911923786 4786 2882570 SGTC_3342 9147791 14.508 µM -2.77620878752358 0.00236126789037915 no 3335 0.00274984392202863 4771 1838168 SGTC_2690 usnic acid 100 µM -2.79385838898102 0.00223165773420439 no 3336 0.00260416404421207 4768 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_307 1501-1223 22.3 µM -2.81731026304574 0.0020694154247638 no 3337 0.00242138593397657 4788 2830329 SGTC_2624 nerol 100 µM -2.84833463816018 0.0018712362569281 no 3338 0.00219743429812963 4749 637566 A natural product oil. SGTC_761 k216-0224 480 µM -2.94666800283825 0.00135171274330395 no 3339 0.00160608937160375 4790 1340404 SGTC_2104 5389443 200 µM -2.94899924051594 0.00134117807224034 no 3340 0.00159402379758396 4787 2244536 SGTC_465 cgp-37157 41 µM -3.03249512227405 0.00100988587119652 no 3341 0.00121270508590848 4805 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1915 st067105 30.6 µM -3.04333955510545 0.000972866234430944 yes 3342 0.00116984084065473 4763 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2623 humulene 100 µM -3.0437132212216 0.000971613143167774 yes 3343 0.00116838890479995 4776 6187145 An anti-inflammatory. SGTC_1619 st003326 88.7 µM -3.17608293090014 0.00061021485829465 yes 3344 0.000746391348358738 4778 2849032 SGTC_101 0490-5701 117.494 µM -3.1928745214111 0.000574547142641945 yes 3345 0.000704320715145242 4781 4661669 SGTC_443 clozapine 122 µM -3.20366803794001 0.000552648252739061 yes 3346 0.000678444153914668 4791 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_446 go6976 132 µM -3.22322536373707 0.000514923320431265 yes 3347 0.000633778918903276 4800 3501 A protein kinase C inhibitor. SGTC_696 1560-0013 611 µM -3.23407299413431 0.000495040756354215 yes 3348 0.000610191302381011 4798 1650269 SGTC_709 3807-1509 243 µM -3.2575635040476 0.000454397422956227 yes 3349 0.000561865558526368 4807 1886677 YPL242C IQG1 SGTC_2691 st077356 60.2 µM -3.31945818604822 0.000361642455927166 yes 3350 0.000450961554018621 4789 2839272 SGTC_2994 9053520 71.4286 µM -3.35146126970625 0.000320899629821941 yes 3351 0.000401931412341465 4795 4647384 SGTC_290 2043-6722 48.1 µM -3.6409676288195 0.000103960597624626 yes 3352 0.000135807644725336 4809 773758 YLR208W SEC13 SGTC_442 cape 100 µM -3.74128572354108 6.9001094949751e-05 yes 3353 9.15406172678977e-05 4805 5281787 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -4.12983757269533 1.28344134391441e-05 yes 3354 1.81509807729061e-05 4805 551469 SGTC_1998 st075797 76.8 µM -4.60545644884453 1.33343406643825e-06 yes 3355 2.05781057816931e-06 4810 24208315 SGTC_571 k831-0106 44.2 µM -6.01916094982587 4.13124933570898e-10 yes 3356 8.76617379712926e-10 4810 4783639