SGTCid condition conc unit DSS1|YMR287C.score DSS1|YMR287C.strain.pval DSS1|YMR287C.strain.significant DSS1|YMR287C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_236 1509-0011 5.31 µM 26.4497427443429 7.41081659164154e-114 yes 1 1.83684494538139e-154 27 3107280
SGTC_173 1273-0061 2.693 µM 16.5552207750342 5.47324097316075e-46 yes 2 7.34009904273848e-62 5 2847414 YPL266W DIM1
SGTC_310 1273-0058 1.06 µM 13.4507739856849 4.48637098843813e-31 yes 3 1.52333253187792e-41 16 2734232
SGTC_832 4083-0019 164 µM 8.10530778837399 1.66735663688951e-12 yes 4 2.63060785433081e-16 8 1990758
SGTC_63 0099-0242 26.702 µM 6.86897319162697 1.75493180425763e-09 yes 5 3.23328279457218e-12 19 3898502 YLR359W ADE13
SGTC_68 0986-0284 82.829 µM 6.80314330453853 2.46536137685274e-09 yes 6 5.11803666456116e-12 12 423278 YIL048W NEO1
SGTC_10 0279-0212 42.575 µM 6.56690919316618 8.139260769177e-09 yes 7 2.5685175705699e-11 22 39851 YBR002C RER2
SGTC_275 trichlorophene 5.69 µM 5.97991903033889 1.33307382992363e-07 yes 8 1.11624281057811e-09 122 62616
SGTC_70 0141-0289 43.283 µM 5.79915856157263 3.00202737581403e-07 yes 9 3.33242456916567e-09 88 352408
SGTC_831 k061-1017 217 µM 5.77888197797626 3.28349612581456e-07 yes 10 3.75993259469126e-09 13 1240153
SGTC_1965 Pectolinarigenin 58.4 µM 5.70490400385574 4.54224506158335e-07 yes 11 5.82043377675699e-09 1 5320438 An anti-inflammatory.
SGTC_1955 wogonin 32.4 µM 5.68266860199116 5.00383054094814e-07 yes 12 6.63045376327468e-09 5 5281703 A flavanone.
SGTC_19 0279-0214 38.434 µM 5.31498644176082 2.35710995076222e-06 yes 13 5.33326343372611e-08 16 3566274 YBR002C RER2
SGTC_28 pentachloropyridine N-oxide 1.606 µM 4.66076099871203 2.93773769502409e-05 yes 14 1.57521191053317e-06 38 140250 A respiratory chain inhibitor.
SGTC_283 0987-0079 11.7 µM 4.47970629673195 5.6011777989052e-05 yes 15 3.7372908893714e-06 13 411556
SGTC_1154 4088-0362 150 µM 4.3585388867406 8.51752758212479e-05 yes 16 6.54668298245613e-06 12 6618304
SGTC_1742 st038235 28.8875 µM 4.32059921264191 9.69174838276001e-05 yes 17 7.78030370716352e-06 102 564103 YBR002C RER2
SGTC_2250 alverine citrate 130 µM 4.29444584561738 0.000105880014403091 yes 18 8.7565110812871e-06 134 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_879 0831-1030 162 µM 4.27743634074974 0.000112120667566662 yes 19 9.45289991439054e-06 35 1549252
SGTC_876 0720-0963 56.8 µM 4.13453336628739 0.000179973299484205 yes 20 1.77838289149688e-05 11 765861
SGTC_630 4356-0227 183 µM 3.95854390864426 0.000316156346117536 yes 21 3.77040397110704e-05 10 779312
SGTC_532 1548-0774 215 µM 3.95497107800804 0.000319722771798945 yes 22 3.82719554531789e-05 18 5932993
SGTC_66 0109-0187 42.4 µM 3.93770814618788 0.00033748804337397 yes 23 4.11317822533633e-05 41 759417
SGTC_2533 agelasine 13.65 µM 3.92470448010813 0.000351471453190146 yes 24 4.34181361612713e-05 50 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2630 antimycin a 100 µM 3.83797310221276 0.000459408046143401 yes 25 6.20270334207343e-05 42 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2598 perillyl alcohol 100 µM 3.81887279754838 0.000486980084186952 yes 26 6.70314331611971e-05 38 10819 An apoptosis inducer.
SGTC_1319 1306-0155 43.7 µM 3.8094285878723 0.000501172182344098 yes 27 6.96441644925621e-05 28 3122360
SGTC_614 0462-0418 107 µM 3.80641656080831 0.00050577836183159 yes 28 7.0497415063765e-05 33 5188303
SGTC_1623 st003709 20.3 µM 3.79857776466992 0.000517950266577797 yes 29 7.27643850605624e-05 81 16192618
SGTC_908 3448-7491 47.7 µM 3.68979373439864 0.000717343581928701 yes 30 0.000112217976171716 137 1203031
SGTC_3140 9094243 49.47 µM 3.64949236755562 0.00080767020659306 yes 31 0.000131379523204662 34 19291112
SGTC_1963 st076565 50.3 µM 3.63496026241086 0.000842730148000423 yes 32 0.000139011743185403 17 4914280
SGTC_691 1548-0686 185 µM 3.61825181129921 0.000884767984551594 yes 33 0.000148299871597371 50 46495133
SGTC_969 1313-0238 134 µM 3.57078499175686 0.00101493225087202 no 34 0.000177956484053347 36 5212874
SGTC_800 3448-7362 155 µM 3.55759243002943 0.00105410895903112 no 35 0.000187134712411083 199 15991913
SGTC_2133 5320837 200 µM 3.54523755469647 0.00109205081359447 no 36 0.000196129696750054 41 2841355
SGTC_882 0843-0131 351 µM 3.53347222211027 0.00112934183941534 no 37 0.000205069593196165 23 5425421
SGTC_2283 7944793 200 µM 3.52772836079803 0.00114796803633084 no 38 0.000209571022565897 67 2970533
SGTC_1961 st076550 68.7 µM 3.51809859277593 0.00117982783024353 no 39 0.000217325421519405 23 1579337
SGTC_820 1582-0060 59.9 µM 3.44173253785447 0.00146261485845402 no 40 0.00028900071940223 53 3848840
SGTC_2232 chlorophetanol 41.5365 µM 3.43871313268002 0.00147497282370984 no 41 0.000292243120495198 161 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2802 7925815 54.55 µM 3.43123832661082 0.00150597704200506 no 42 0.000300416242200021 60 1262923
SGTC_87 0100-0052 35.5 µM 3.41204602251312 0.00158832539044996 no 43 0.000322386131764404 160 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_3167 9103034 49.47 µM 3.41038964200312 0.00159562137880805 no 44 0.000324350654274282 9 5127859
SGTC_673 1082-0474 110 µM 3.4069939157517 0.00161067437820935 no 45 0.000328412955763252 90 3098046
SGTC_147 4466-0538 29.23 µM 3.3884077398034 0.00169538212754049 no 46 0.000351498372958719 46 6742687 YHR072W ERG7
SGTC_1126 isoteolin 1.0172 µM 3.36361534553021 0.00181468851031776 no 47 0.000384643409136454 53 133323
SGTC_631 k072-0230 41.5 µM 3.36114603619436 0.00182698005521755 no 48 0.000388098870209671 36 5773147
SGTC_26 0302-0163 425.158 µM 3.35997814757709 0.0018328198138202 no 49 0.000389743188790781 20 3100915
SGTC_1944 st076371 56.9 µM 3.35186862557808 0.00187383996231523 no 50 0.000401340495654863 40 24208455
SGTC_148 3253-0744 288.01 µM 3.30805362647543 0.00211025439808346 no 51 0.000469734090378909 41 6893655
SGTC_2864 9034755 47.6 µM 3.30233521013323 0.00214302862537506 no 52 0.000479417045154473 30 4930451
SGTC_1318 1280-3875 124 µM 3.30206012298476 0.00214461681943371 no 53 0.000479887476492106 51 373245
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 3.29674139445243 0.00217553463580358 no 54 0.000489067593883051 151 16725076
SGTC_1172 0370-0043 85 µM 3.28129978544907 0.00226759988862672 no 55 0.000516649274624127 44 376585
SGTC_119 0121-0043 24.815 µM 3.27786225794708 0.00228856927569452 no 56 0.000522982110703557 165 1092378
SGTC_1614 st002383 48.6 µM 3.27776333488196 0.00228917531130144 no 57 0.000523165411924128 33 1947235
SGTC_2960 9079389 5.97 µM 3.24499911568044 0.00249808370083646 no 58 0.00058725494198313 56 16457355
SGTC_1883 5-benzylidenerhodanine 20 µM 3.19886208693528 0.00282151280416511 no 59 0.000689855767685119 117 1273210
SGTC_1622 st003707 19.4 µM 3.19853819136263 0.00282391110477335 no 60 0.000690631181353993 74 10140899
SGTC_735 3076-0345 636 µM 3.18244206093826 0.00294543720057232 no 61 0.000730193657958454 68 2888990
SGTC_523 1934-0222 13.7 µM 3.15315634094462 0.00317869377298095 no 62 0.000807576394654255 63 1361595
SGTC_748 act1.228 77.9 µM 3.15231644918388 0.00318562202690426 no 63 0.000809903118884147 120 4421505 YNR035C ARC35
SGTC_1066 ketoconazole 628 nM 3.15153678252808 0.00319206564394978 no 64 0.000812068523992988 54 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_386 1509-0011 3.07 µM 3.15131413544684 0.00319390788000993 no 65 0.000812687869616661 185 3107280
SGTC_782 0083-0095 30.5 µM 3.12891410261708 0.0033842145232581 no 66 0.000877267953125665 65 3591729 An indicator and reagent.
SGTC_2016 5121758 140 µM 3.08494064363171 0.00378769917685155 no 67 0.00101796389764228 100 2795203
SGTC_2727 riluzole 51.77 µM 3.0751736998613 0.0038829701387663 no 68 0.00105189995155728 37 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_967 1306-0166 352 µM 3.00709465757915 0.00460885202922402 no 69 0.00131878809302506 83 4437607
SGTC_14 0354-0009 295 µM 2.97855428162299 0.00494759573622566 no 70 0.00144805863200799 74 1713507
SGTC_1069 diphenylcyclopropenone 8.49 µM 2.97622828421599 0.00497615676225174 no 71 0.00145908774080868 74 65057 A dermal irritant. YDR527W RBA50
SGTC_365 0121-0052 13.6 µM 2.96766252248948 0.00508260660906496 no 72 0.00150036798403034 132 3101739
SGTC_633 0437-0093 97.7 µM 2.96342697864689 0.00513598860399459 no 73 0.0015211711768175 52 2831118
SGTC_168 3970-0862 530.542 µM 2.95089459530362 0.00529687302734796 no 74 0.00158427513082027 228 3135186
SGTC_2900 5328528 85.29 µM 2.93748248685179 0.00547400179385664 no 75 0.0016544443015798 86 795359
SGTC_1939 st074455 53.6 µM 2.92843832573615 0.00559639718953109 no 76 0.00170334705255278 87 1644229
SGTC_2669 eugenol 100 µM 2.92463174158919 0.00564863465649917 no 77 0.00172432034623441 31 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_3323 9138564 53.9225 µM 2.91609373426401 0.00576737855103309 no 78 0.00177221998669978 73 43912313 YNL103W MET4
SGTC_2729 fluphenazine 10.66 µM 2.90959573362799 0.00585922984660852 no 79 0.0018094826643611 65 3372 An atypical antipsychotic.
SGTC_826 1683-5028 118 µM 2.90789017238423 0.00588355247836408 no 80 0.00181938052957107 60 722377
SGTC_2705 st078069 42.8 µM 2.9008629957174 0.00598471269703428 no 81 0.00186068271384089 49 1530061
SGTC_979 1426-2828 121 µM 2.88942866404055 0.00615261465945171 no 82 0.00192971281453069 80 747872
SGTC_427 1354-0053 47.3 µM 2.87848470999519 0.00631721068571085 no 83 0.00199795325355705 73 6813657
SGTC_1247 0448-0043 5.84 µM 2.87605709234928 0.00635424576828176 no 84 0.00201338435423645 120 3089013 YGL099W LSG1
SGTC_2241 6772625 37.8075 µM 2.87485577579956 0.00637264370996269 no 85 0.0020210604450649 75 2285411
SGTC_2688 kanamycin b 96.69 µM 2.86342926566629 0.00655000906491396 no 86 0.0020954118666261 569 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_717 1532-0246 73.2 µM 2.85309247062795 0.00671420606134003 no 87 0.00216480104563746 96 9561992
SGTC_596 1155-0152 116 µM 2.83806931268383 0.00695932886661147 no 88 0.00226936627229181 108 280313
SGTC_819 1013-0258 27.7 µM 2.83739551785781 0.00697050550715684 no 89 0.00227416151642904 89 5753198
SGTC_545 4218-0007 221 µM 2.81389332261742 0.00737039770725168 no 90 0.00244727340033201 76 2840508
SGTC_1922 5578187 25 µM 2.80673764196604 0.00749610286448313 no 91 0.00250229916066057 102 1350412
SGTC_2106 5357045 167.29 µM 2.78351680969885 0.00791713085590844 no 92 0.0026886537982677 68 668842
SGTC_2992 9074591 71.4286 µM 2.78263408565839 0.00793353833778518 no 93 0.00269597899373032 60 17741321
SGTC_2041 5107442 45.335 µM 2.77994548212776 0.00798369667846726 no 94 0.00271840125492498 91 793005
SGTC_1597 7-benzyloxygramine 47.5 µM 2.77853264011551 0.00801016611973443 no 95 0.00273025134789234 260 260807
SGTC_118 0083-0097 135.343 µM 2.77645462768687 0.00804923764119164 no 96 0.00274776523971391 310 5207356
SGTC_144 4161-2749 112.381 µM 2.76322462843043 0.00830194389762359 no 97 0.00286166816390165 64 797501 YMR168C CEP3
SGTC_274 sirtinol 40.1 µM 2.74803452278936 0.00860065903441154 no 98 0.0029976848033575 83 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_116 0155-0182 31.788 µM 2.73072235319807 0.00895256403589707 no 99 0.00315978433717226 190 771486
SGTC_1150 3909-7983 10.9 µM 2.72793487691344 0.00901038880421721 no 100 0.00318660943990463 90 23965914
SGTC_851 0394-0702 453 µM 2.69695524198242 0.0096753958104457 no 101 0.00349883375721034 71 762646
SGTC_2238 6671620 73.2395 µM 2.6894118924937 0.00984367201407707 no 102 0.00357890197717576 97 729941
SGTC_778 3456-2434 196 µM 2.6727075958258 0.0102254318157024 no 103 0.00376209016710397 163 5539063
SGTC_161 4065-0411 162.148 µM 2.65579516039428 0.0106250407723469 no 104 0.00395608293796967 166 1906281 YLR208W SEC13
SGTC_2233 sulbentine 40.3845 µM 2.64118132804054 0.0109812249495993 no 105 0.00413087442771222 161 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_609 0986-0026 86.3 µM 2.63599170798617 0.0111101883091262 no 106 0.00419458907749565 126 2848610
SGTC_2378 9074213 121.43 µM 2.62723687072683 0.0113307344466488 no 107 0.00430406943640069 102 657714
SGTC_177 1327-0068 8.361 µM 2.59771037732953 0.0121028342455468 no 108 0.00469238062374666 143 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1615 st002656 86.5 µM 2.57315936032725 0.012779158550033 no 109 0.00503873970688474 86 1584458
SGTC_903 1134-0042 114 µM 2.56137368827042 0.0131152805416446 no 110 0.00521295728390743 107 701009
SGTC_15 0266-0086 27.098 µM 2.55466882415398 0.0133098891633428 no 111 0.00531444360342322 184 1712902 YIL048W NEO1
SGTC_680 0417-1641 114 µM 2.55314784834607 0.0133543809444108 no 112 0.00533770849653406 90 2835990
SGTC_892 0929-0076 29 µM 2.53843202346432 0.0137915244707256 no 113 0.00556752161251602 151 5751038
SGTC_503 tyrphostin 8 294 µM 2.53243864927525 0.0139730675233978 no 114 0.00566360949883729 133 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2889 9059656 51.95 µM 2.51877789855106 0.0143945747778629 no 115 0.00588814566749942 84 3949838
SGTC_211 3455-0679 143.504 µM 2.50626550451808 0.014790209798783 no 116 0.00610069804228011 115 748649
SGTC_1177 0983-0204 23.6 µM 2.50349367365163 0.0148791080854006 no 117 0.00614869394373129 96 766818
SGTC_2333 9017922 200 µM 2.50236645132215 0.0149153916073309 no 118 0.00616830795294551 128 3163164
SGTC_2195 6536160 144.242 µM 2.50074889767415 0.0149675910147424 no 119 0.00619655070424904 89 3834386
SGTC_424 splitomicin 100 mM 2.49733485868815 0.0150782797621098 no 120 0.00625653664310928 121 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2826 7992541 19.48 µM 2.48591045114776 0.015453807903722 no 121 0.00646102385099192 120 2985066
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 2.47560766991144 0.0157993247160854 no 122 0.00665048247636754 109 165521
SGTC_767 0929-0023 86 µM 2.47481188447891 0.0158262858958438 no 123 0.00666531851811999 235 1204563
SGTC_2454 5-benzylidenerhodanine 10.36 µM 2.4644879568889 0.0161796519466211 no 124 0.00686045872182309 155 1273210
SGTC_539 4859-0462 2.54 µM 2.45656489101054 0.0164554062924558 no 125 0.00701362330662072 130 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2526 patulin 37.61 µM 2.45510502806459 0.0165066519184678 no 126 0.0070421715976937 235 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1526 st051518 75 µM 2.45437628867879 0.0165322839617739 no 127 0.00705646076759381 112 673993
SGTC_563 tetrahydrosecaminediol 614 µM 2.43761488392394 0.0171313078267963 no 128 0.00739225775642756 129 334274 A psychoactive constituent of the cannabis plant.
SGTC_141 0443-0274 32.331 µM 2.42305202527978 0.0176667238266506 no 129 0.00769536118940136 212 1627241
SGTC_1702 st027038 51 µM 2.40121385901173 0.0184963546847121 no 130 0.00817039168718579 119 5521182
SGTC_1807 st050092 58.9 µM 2.39138058514539 0.0188806188653154 no 131 0.00839257162637393 129 5008496
SGTC_629 3448-6466 76.7 µM 2.39114081186423 0.0188900729021602 no 132 0.00839805484039375 135 573744
SGTC_601 0986-0029 62.9 µM 2.38659832883739 0.0190699410361215 no 133 0.00850252961647619 185 24747981
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 2.37872032031118 0.0193853388302556 no 134 0.00868642577799638 161 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1188 1403-0014 4.57 µM 2.37517761921068 0.0195286099082728 no 135 0.00877025363996274 208 9614867
SGTC_3094 9117742 49.47 µM 2.37461790625974 0.0195513274363681 no 136 0.00878356231259528 156 17149698
SGTC_464 bw-b 70c 158 µM 2.36011393354793 0.0201478862887648 no 137 0.00913466157993001 172 5353454
SGTC_1107 amlodipine 47 µM 2.35957893182669 0.0201701833039397 no 138 0.00914784412870654 155 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2091 4-phenylthiadiazole 200 µM 2.35919874099078 0.0201860410537912 no 139 0.00915722222679507 133 270010
SGTC_3163 9099914 49.47 µM 2.34844930778662 0.0206387943171979 no 140 0.00942588255606943 45 16268368
SGTC_2310 7668677 200 µM 2.34228162643784 0.020902431929838 no 141 0.0095831231794784 162 2197143
SGTC_581 0958-0271 211 µM 2.34139748075659 0.0209404573582184 no 142 0.00960585071509922 220 4591145
SGTC_1627 st003713 25.6 µM 2.33733936105729 0.0211157413189184 no 143 0.00971077271841165 258 16195070 YER133W GLC7
SGTC_1371 2421-0008 32.7 µM 2.33517505204102 0.0212097316492786 no 144 0.00976713893023036 192 2827552
SGTC_1040 k898-0338 155 µM 2.33186174806084 0.0213543052625176 no 145 0.00985398268573277 148 20969351
SGTC_679 0422-0091 41.4 µM 2.3145226304354 0.0221245442959879 no 146 0.0103195356814062 180 627384 YHR062C RPP1
SGTC_3206 9114350 49.47 µM 2.30793969887856 0.0224230498598203 no 147 0.0105012453177978 137 17087243
SGTC_1284 0929-0043 16 µM 2.29891628513584 0.0228377331983442 no 148 0.0107548467379197 149 1239883
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 2.29740255267488 0.0229079278998345 no 149 0.0107979081474945 96 688803
SGTC_2460 5552655 174.22 µM 2.2934157297628 0.0230936748316536 no 150 0.0109120409450501 164 5401989
SGTC_2312 7706453 155.7 µM 2.2891583953312 0.0232934235600642 no 151 0.0110350754689429 157 976098
SGTC_744 1594-0068 283 µM 2.28737157727221 0.0233776909883875 no 152 0.0110870719166478 187 668392
SGTC_2732 terfenadine 20 µM 2.28612002542158 0.023436867585172 no 153 0.0111236188801062 101 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_38 0929-0051 58.268 µM 2.28472861986617 0.0235028047235909 no 154 0.0111643726906813 176 1379719
SGTC_1978 st071761 42 µM 2.28082655161404 0.0236885523534658 no 155 0.0112793562778628 114 5147680
SGTC_3312 9133330 71.43 µM 2.27918753617976 0.023766940684708 no 156 0.011327959842381 123 17617324
SGTC_697 0508-1955 564 µM 2.27779477352522 0.0238337229041074 no 157 0.0113694039373161 186 6243113
SGTC_686 1319-0111 510 µM 2.27755998722916 0.023844996303132 no 158 0.0113764033768119 160 4562600
SGTC_204 PMA1.184 62.41 µM 2.27663638777383 0.0238893869690765 no 159 0.0114039740329997 166 2252213 YGL008C PMA1
SGTC_2254 7938975 95.19 µM 2.27648705645481 0.0238965707516506 no 160 0.0114084372164449 198 2969277
SGTC_1402 3909-7673 35.9 µM 2.27118612021315 0.024152758043685 no 161 0.0115678566486909 148 5328014
SGTC_462 ag-879 158 µM 2.26845502774387 0.0242856461540128 no 162 0.0116507435478837 176 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1444 4112-3581 28 µM 2.26100743724811 0.0246511506446733 no 163 0.0118793982620504 142 2877249
SGTC_2497 7-hydroxyflavone 100 µM 2.25414819531213 0.0249918529634415 no 164 0.0120934232788572 149 5281894
SGTC_2813 7971799 71.43 µM 2.24450911986743 0.025477295916536 no 165 0.0123998314029184 155 2234054
SGTC_1882 5615643 20 µM 2.23783078549283 0.0258182408575937 no 166 0.0126160460075682 137 2253075
SGTC_3280 9140961 49.47 µM 2.23494973628129 0.0259664998006208 no 167 0.0127103243944026 123 4901226
SGTC_1695 st026914 34.495 µM 2.22585026123326 0.0264394437789721 no 168 0.0130121064558464 166 3289191
SGTC_1183 1254-0324 198 µM 2.20287656064695 0.0276656128897047 no 169 0.0138017250476747 148 5799357
SGTC_385 1494-0393 12.4 µM 2.17986649604262 0.0289408666737064 no 170 0.0146336795412708 185 3090647
SGTC_711 k292-0785 179 µM 2.17787895329575 0.0290532754015125 no 171 0.0147075249075979 164 4146315
SGTC_1052 3253-3998 198 µM 2.1773933589098 0.0290807940626222 no 172 0.0147256153828026 203 5450317
SGTC_2733 amorolfine 100 µM 2.16806884130825 0.0296134294807124 no 173 0.0150767245669079 70 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2078 5212016 200 µM 2.15078545901513 0.0306221026417204 no 174 0.0157465686730585 132 1899708
SGTC_2962 9082311 13.18 µM 2.14260846356028 0.0311091425384658 no 175 0.0160722754944619 171 16459453
SGTC_2749 bexarotene 57.39 µM 2.13872327785002 0.0313427888566676 no 176 0.0162290431171257 215 82146 An retinoic acid receptor inhibitor.
SGTC_534 k292-0788 63.4 µM 2.1349400658779 0.0315716952770019 no 177 0.0163829530303807 193 4146317
SGTC_791 1348-1292 225 µM 2.13361102834608 0.0316524370562948 no 178 0.0164373172370626 256 5437054
SGTC_625 k213-0058 121 µM 2.13191815581423 0.0317555295905232 no 179 0.0165067876935678 353 3655420
SGTC_3184 9108758 49.47 µM 2.12242664739721 0.0323386935606261 no 180 0.0169009632212833 133 902885
SGTC_2825 7998094 58.44 µM 2.11793175207527 0.0326179305570989 no 181 0.0170904240223536 191 2987815
SGTC_1292 0kpi-0043 232 µM 2.10902946814577 0.0331768382296162 no 182 0.0174710190589997 172 3333905
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 2.09813557710527 0.0338714935632066 no 183 0.0179465852829126 191 688662
SGTC_1671 st016596 74.5 µM 2.09786644740605 0.0338888050717635 no 184 0.0179584723471498 193 2829167
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 2.09478902405083 0.0340872752630397 no 185 0.0180948756243332 192 6708760
SGTC_2803 7707263 71.43 µM 2.09455726721193 0.0341022604177833 no 186 0.0181051836459998 191 2199229
SGTC_2713 st079149 53.4 µM 2.08973117258419 0.0344155433892527 no 187 0.0183209775663011 215 3103253
SGTC_995 3931-2021 34.6 µM 2.085599144916 0.034685647017153 no 188 0.0185074744397678 191 730143
SGTC_1274 0865-0114 173 µM 2.08271233984112 0.0348753836540919 no 189 0.0186387259893522 198 870624
SGTC_3122 9126309 49.47 µM 2.0765509575123 0.0352831939108951 no 190 0.0189215116603089 158 17591206
SGTC_700 3453-2283 142 µM 2.06735706186899 0.0358989861348512 no 191 0.0193502605381688 233 565664
SGTC_1693 xanthone 101.9 µM 2.06721547374096 0.0359085378818745 no 192 0.0193569273885995 200 7020 An insecticide.
SGTC_84 0443-0269 128.823 µM 2.06057836121144 0.0363586289793352 no 193 0.0196716414530529 217 6150058
SGTC_1921 5740136 50 µM 2.05762109587391 0.0365606556078514 no 194 0.0198132599851622 266 1774243
SGTC_297 0986-0032 24 µM 2.05612125736428 0.0366634680909944 no 195 0.0198854148689325 162 2847425
SGTC_50 0929-0078 56.389 µM 2.05064167292336 0.037041100442959 no 196 0.0201509274736999 231 1377751
SGTC_799 1310-0557 151 µM 2.04508728756235 0.0374271264233918 no 197 0.0204231266753857 216 5354492
SGTC_405 ebelactone b 50 µM 2.04126875271854 0.0376944131219509 no 198 0.0206120605839564 205 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2308 7584454 197.62 µM 2.03907721337897 0.0378485171620378 no 199 0.0207211609960375 244 893577
SGTC_2680 butyl paraben 22.24 µM 2.0314376065451 0.0383897413677383 no 200 0.0211053114046856 149 7184 An antifungal and steroid mimetic.
SGTC_2165 5727197 32.143 µM 2.02952810654202 0.0385259999775867 no 201 0.0212022645994797 245 1361712
SGTC_1662 st014054 52 µM 2.02407101147049 0.0389175828165473 no 202 0.0214814228943229 158 2838777
SGTC_2743 auranofin 4.32 µM 2.01696992349234 0.0394319795705344 no 203 0.0218493260542573 202 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2799 7812892 81.82 µM 2.01261795771996 0.0397499567087177 no 204 0.0220774181539168 233 20205235
SGTC_582 0987-0078 156 µM 2.01156275824932 0.0398273682364857 no 205 0.0221330242537023 349 1625765
SGTC_55 0767-0285 6.563 µM 2.0108418451287 0.039880326284557 no 206 0.0221710823109139 264 3116166
SGTC_210 3551-0445 56.827 µM 1.99797014423797 0.0408355486297639 no 207 0.0228599485082678 246 2865180 YOR207C RET1
SGTC_2053 5265679 138 µM 1.99383979795965 0.0411459708131512 no 208 0.0230847823814027 258 764595
SGTC_2922 7999257 32.47 µM 1.99082208244657 0.0413739790824663 no 209 0.0232502253735827 174 2988377
SGTC_1848 st056003 16.4 µM 1.99000898680798 0.0414355886276121 no 210 0.0232949727711184 213 146492
SGTC_2983 9022671 12.99 µM 1.9853197034765 0.0417923552744572 no 211 0.0235544566139292 203 6405161
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.98078179136512 0.0421399698816759 no 212 0.0238078748288566 174 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1134 3477-0009 42.5 µM 1.97959736728346 0.0422310835533553 no 213 0.0238743945312852 266 3973534
SGTC_2486 5283202 22.39 µM 1.97734305249593 0.0424049406281089 no 214 0.0240014331647015 233 1377751
SGTC_3221 9128209 49.47 µM 1.97422633648639 0.042646260768125 no 215 0.0241780063129177 192 16460723
SGTC_2952 9073731 13.78 µM 1.96965521447824 0.0430021993796039 no 216 0.0244389495080356 279 16457353
SGTC_1303 1160-0052 261 µM 1.96883873086734 0.043066028279779 no 217 0.0244858065622177 219 3562476
SGTC_2808 7946468 45.46 µM 1.96292069482238 0.0435309638728158 no 218 0.0248276948528739 278 2970879
SGTC_949 1165-0505 146 µM 1.96092044034131 0.0436890218424676 no 219 0.0249441522454327 261 6244267
SGTC_1621 st003705 32.4 µM 1.95968069720324 0.0437872172472923 no 220 0.0250165613452308 253 24207032
SGTC_1291 0993-0025 5.79 µM 1.95638014805571 0.0440495095639243 no 221 0.0252101944831394 205 4353356
SGTC_1426 4048-4480 71.7 µM 1.95300994595988 0.0443186429484003 no 222 0.0254092083348767 207 14224343
SGTC_2771 fluoxetine 41.05 µM 1.9445646253737 0.0449988825456568 no 223 0.0259137001565881 209 3386 A selective serotonin reuptake inhibitor.
SGTC_2463 5473429 200 µM 1.94325872216248 0.045104814549545 no 224 0.025992453092842 210 5399405
SGTC_1564 D-Arginine 115 µM 1.9314303178919 0.0460734756052276 no 225 0.0267149294401935 256 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_127 0180-0333 59.125 µM 1.92969186393914 0.0462172405881697 no 226 0.0268225143303336 326 771601
SGTC_2183 6420625 130.508 µM 1.91395682396983 0.0475349292835765 no 227 0.0278128363844527 329 2897619
SGTC_2263 7948595 193.29 µM 1.91390340577178 0.0475394533726316 no 228 0.0278162495791021 180 2971371
SGTC_2611 pyromycin 23.93 µM 1.91324289452619 0.0475954218342972 no 229 0.0278584822690463 270 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_849 0386-0493 241 µM 1.91077407967277 0.0478050844728486 no 230 0.0280168100444329 215 726119
SGTC_973 1325-0077 65.9 µM 1.90967593898648 0.0478985807306678 no 231 0.0280874754083163 250 2835149
SGTC_1289 0976-0073 69.1 µM 1.9054357959989 0.0482609632568085 no 232 0.0283617229186103 236 3391136
SGTC_2484 5809818 12.04 µM 1.90336867345316 0.0484384228009058 no 233 0.0284962278473584 239 2870548
SGTC_3053 9095903 49.47 µM 1.89091127889436 0.0495189476408213 no 234 0.0293180942826396 194 17174018
SGTC_2277 7947813 106.88 µM 1.89048668478113 0.0495561122229583 no 235 0.0293464498630612 268 1246798
SGTC_2107 5363541 170.161 µM 1.87571969323469 0.0508625689382625 no 236 0.0303468901388085 242 244052
SGTC_1191 1487-1166 10.6 µM 1.8730821457304 0.0510987772433503 no 237 0.0305285212158436 307 3955771
SGTC_1197 1601-0112 267 µM 1.85295258697355 0.0529303748317991 no 238 0.0319445773642553 290 7350313
SGTC_1073 triclabendazole 3.09 µM 1.84331256413441 0.0538257748699415 no 239 0.0326416938829426 321 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1755 st041960 45.185 µM 1.83923492703092 0.0542081119937577 no 240 0.0329403197705693 255 2257073
SGTC_3353 9151644 39.2805 µM 1.83822552770794 0.0543030887635836 no 241 0.0330145898258904 261 4909158
SGTC_871 0574-0004 149 µM 1.83587513037761 0.0545247534132343 no 242 0.0331880633046077 309 9551173
SGTC_3079 9117512 49.47 µM 1.8348364969139 0.0546229340502586 no 243 0.0332649595647681 176 7185044
SGTC_874 0599-0792 117 µM 1.83222195280817 0.0548707023157445 no 244 0.0334591797427282 318 765305
SGTC_1776 st049249 45.9 µM 1.8285815182717 0.0552171679395054 no 245 0.0337311617296599 295 1822314
SGTC_2058 5236698 133 µM 1.82301710541987 0.0557500779449785 no 246 0.0341504001014548 281 766665
SGTC_2903 5923464 63.88 µM 1.82053327269116 0.0559892637608406 no 247 0.0343389170177441 217 2876576
SGTC_314 1671-0008 2.74 µM 1.81900300725871 0.0561370263214393 no 248 0.0344554856404043 334 3913060
SGTC_2626 ethyl orsellinate 100 µM 1.81633776315043 0.0563951165373804 no 249 0.0346592879114733 263 75653 A natural product.
SGTC_1231 0242-0792 125 µM 1.81365152186289 0.0566561854326004 no 250 0.0348656964878613 268 3707635
SGTC_3300 9124615 50.48 µM 1.80935842006347 0.0570753966858192 no 251 0.0351976692320794 299 24824903
SGTC_588 3970-1144 52.9 µM 1.80661210351453 0.0573448461199308 no 252 0.0354113905005855 296 1888707
SGTC_964 1287-0107 19.4 µM 1.80628883737579 0.0573766284726215 no 253 0.0354366172714986 322 51516812 YPR165W RHO1
SGTC_6 0844-0013 19.835 µM 1.80325240460795 0.0576758364062642 no 254 0.0356742918713125 545 1584900
SGTC_2761 levamisole 97.89 µM 1.80209072312178 0.0577906316606733 no 255 0.0357655665129414 268 26879 An alkaline phosphatase inhibitor.
SGTC_676 falcarinol 140 µM 1.79912801503382 0.0580842144147224 no 256 0.0359992165109153 316 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2024 5144227 134 µM 1.78585093639793 0.0594142941100976 no 257 0.0370616984239003 329 3475211
SGTC_519 k048-0011 62.8 µM 1.7852462033583 0.0594754392991344 no 258 0.0371106953104498 295 6836379
SGTC_51 1013-0126 23.419 µM 1.78476932370538 0.0595236918744114 no 259 0.0371493705383318 277 1627850
SGTC_770 0389-1121 67.2 µM 1.78207707079399 0.0597966805156931 no 260 0.0373683321906064 346 6753108
SGTC_2156 5649887 115 µM 1.7780232549386 0.0602095777846286 no 261 0.0377000178009764 323 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_120 rhodamine 6G 52.259 µM 1.77279225141582 0.0607456704992855 no 262 0.0381315689288705 386 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2674 ligustilide 100 µM 1.77179681302484 0.0608481082331624 no 263 0.0382141458994243 233 5319022 A signalling regulator.
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.7687785176431 0.0611595382527685 no 264 0.0384654215574531 304 688751
SGTC_1271 0832-2808 169 µM 1.76700089626774 0.0613435365965634 no 265 0.0386140391007231 291 3663794
SGTC_502 l-744,832 89.3 µM 1.76512987375227 0.0615376695678953 no 266 0.03877097048452 295 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2324 6149169 200 µM 1.76163628353269 0.0619014404105769 no 267 0.0390653847380512 264 2888231
SGTC_2523 spermine 47.74 µM 1.7570406639299 0.0623825136030162 no 268 0.0394554391497457 282 1103 A DNA binding polyamine.
SGTC_3282 9108498 15.4605 µM 1.75500987941479 0.0625960244009218 no 269 0.039628808953229 316 16459645
SGTC_2737 bleomycin 30.5 nM 1.75391974869106 0.0627108723145465 no 270 0.0397221295718239 364 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_186 3455-3465 67.277 µM 1.75387506868117 0.0627155829628357 no 271 0.0397259582116469 180 755278
SGTC_1989 st071868 50.2 µM 1.75324630537115 0.0627819032193716 no 272 0.0397798689049429 302 16414057
SGTC_1703 st026983 48.3 µM 1.75300088633111 0.062807804180784 no 273 0.0398009274710412 296 1104023
SGTC_1912 st060209 90.8 µM 1.75011765463773 0.063112717688801 no 274 0.0400490069820935 306 688787
SGTC_2664 lyso-paf C-16 73.48 µM 1.74160919174615 0.064019245152897 no 275 0.0407884259355531 315 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2682 pyrogallin 40.03 µM 1.7373999846963 0.0644714391376857 no 276 0.0411582969798119 348 822798 An ATP competetive kinase inhibitor.
SGTC_1805 st050013 60.3 µM 1.73021606990113 0.0652489320829653 no 277 0.0417958391297403 257 4037144
SGTC_822 1487-0950 154 µM 1.7298601220804 0.0652876435442668 no 278 0.0418276347871075 312 1958375
SGTC_398 bronopol 33.3 µM 1.72807831505985 0.0654816936430039 no 279 0.0419870923397213 331 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2610 ononetin 44.17 µM 1.7276963144845 0.0655233541003227 no 280 0.0420213423309069 379 259632
SGTC_1705 st027868 56.3335 µM 1.72485873559351 0.0658334602473558 no 281 0.0422764668021918 275 292948
SGTC_2540 epiandrosterone 100 µM 1.72464659520492 0.0658566897319686 no 282 0.0422955904152633 431 441302 A steroid.
SGTC_3043 9092303 49.47 µM 1.72396503055654 0.0659313644126912 no 283 0.0423570781269789 302 25236084
SGTC_327 1273-0057 3.96 µM 1.72352446601871 0.0659796691561948 no 284 0.0423968623508739 309 3108138
SGTC_467 ro 31-8220 72.8 µM 1.72330314097663 0.0660039462067015 no 285 0.0424168600315653 380 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2902 5787006 60.46 µM 1.72308333782415 0.066028063171194 no 286 0.0424367277531711 330 591003
SGTC_2296 7971656 126.45 µM 1.71548530680945 0.0668659289061808 no 287 0.043128143496081 352 666570
SGTC_206 4546-0025 72.014 µM 1.7096335247138 0.0675168173650525 no 288 0.0436668311299499 396 6620745 YIL048W NEO1
SGTC_323 4013-0906 34.3 µM 1.70536359032013 0.0679948401003675 no 289 0.0440633172370676 281 2910086
SGTC_330 1488-0319 80.1 µM 1.70364743276311 0.0681876999474679 no 290 0.0442234871605492 302 6846614
SGTC_3002 9075603 71.4286 µM 1.69998570646151 0.0686006118751868 no 291 0.0445668070689832 321 20105405
SGTC_269 exalamide 29 µM 1.69943821677411 0.0686625145365829 no 292 0.0446183231875137 278 3316 A derivative of salicylamide.
SGTC_3172 9105863 49.47 µM 1.69674974508122 0.0689671155565242 no 293 0.0448719917688751 185 2348785
SGTC_1119 parthenolide 318.541 nM 1.69641342241193 0.0690052937455297 no 294 0.0449038067716827 408 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_124 0136-0217 7.121 µM 1.69407245175556 0.0692714840888955 no 295 0.0451257581895653 385 3976905
SGTC_1881 5652484 16 µM 1.68344543187212 0.0704898325922721 no 296 0.0461444472875078 355 2255129
SGTC_2443 5493264 126.67 µM 1.68255510638197 0.0705926483027503 no 297 0.0462306243192894 323 5340055
SGTC_441 propafenone 146 µM 1.68029837325987 0.0708537745243876 no 298 0.0464496387101038 270 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_81 0411-0046 9.971 µM 1.67717088511984 0.0712168816485597 no 299 0.0467545353032741 303 12925265
SGTC_2122 5258151 111.688 µM 1.67688758432532 0.07124984383193 no 300 0.0467822332187604 348 2173356
SGTC_1272 0839-0021 27 µM 1.67642403010777 0.0713038038474351 no 301 0.0468275826433132 354 5027250
SGTC_2278 7948257 134.34 µM 1.67349331240096 0.0716456803519352 no 302 0.0471151109923958 303 1247028
SGTC_2139 5578692 56.4705 µM 1.67117896637177 0.0719165428870868 no 303 0.0473431667659855 288 650991 YMR113W FOL3
SGTC_1980 st071811 45.7 µM 1.66468564986537 0.0726806891198047 no 304 0.0479877437109189 318 4974850
SGTC_3189 9110682 49.47 µM 1.66277821852243 0.072906336791634 no 305 0.0481784191154625 336 17122418
SGTC_2751 anetholtrithion 17.25 µM 1.66043100288361 0.0731847461388019 no 306 0.0484138887583003 358 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1488 4013-0813 75.9 µM 1.65370252665318 0.0739873365500225 no 307 0.0490939845178759 280 2910057
SGTC_2961 9083290 32.55 µM 1.65003352699779 0.0744278087171383 no 308 0.049468039492582 305 17741490
SGTC_2785 7756463 72.73 µM 1.64854472255441 0.0746071131891386 no 309 0.0496204706407955 341 2201551
SGTC_1911 st060208 74.3 µM 1.64805657546073 0.0746659749992341 no 310 0.0496705310645544 375 688783
SGTC_1336 1486-0901 104 µM 1.64741218167593 0.0747437316290632 no 311 0.0497366765877453 337 5006114
SGTC_2469 5655019 90.81 µM 1.6458723756901 0.0749297845677925 no 312 0.0498950186973858 356 2788239
SGTC_2045 5106652 78.05 µM 1.64399427084227 0.0751571917287125 no 313 0.050088692901327 319 673349
SGTC_2390 9097792 176.6 µM 1.63915235616226 0.0757458937995925 no 314 0.0505907667245176 320 4497149
SGTC_1583 clindamycin 39.6 µM 1.63706632912339 0.0760006024502037 no 315 0.0508083055321119 331 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2381 9035592 200 µM 1.63359803962835 0.0764255312076687 no 316 0.0511716398658075 295 4749657
SGTC_818 4072-2707 53.5 µM 1.63136662497051 0.0766998742781994 no 317 0.0514064914055258 312 882871
SGTC_279 1273-0055 2.93 µM 1.62999986472222 0.0768682811637095 no 318 0.0515507627855471 391 2847562
SGTC_93 0109-0045 59.227 µM 1.62552945068622 0.0774210718044306 no 319 0.0520248969167105 456 88733
SGTC_1719 st032227 49.2 µM 1.61843961575355 0.0783039517227955 no 320 0.0527839451371763 362 3125804
SGTC_1094 duloxetine 25.4 µM 1.61709892725811 0.0784717594343993 no 321 0.0529284642031869 369 60834 A selective serotonin reuptake inhibitor.
SGTC_2286 7945697 125 µM 1.61693882765836 0.0784918165610202 no 322 0.0529457430420115 405 1245733
SGTC_2750 bromebric acid 70.15 µM 1.61614200714415 0.0785916992911284 no 323 0.0530318068952801 423 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1235 benzylparaben 21.5 µM 1.61328391820029 0.0789507579084168 no 324 0.0533414193957102 342 7180
SGTC_986 1493-0483 84 µM 1.61134236860961 0.0791953805237229 no 325 0.0535525604836279 335 40079
SGTC_192 3455-0609 60.9 µM 1.61127110147271 0.0792043706260779 no 326 0.0535603232757423 348 3769639
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.60311937147112 0.0802377901058948 no 327 0.0544541509868644 417 23665772 A membrane-active detergent.
SGTC_2566 crystal violet carbinol 226 nM 1.59925105453465 0.0807317393725118 no 328 0.0548824151419288 336 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2801 7907800 81.82 µM 1.59378311388274 0.081433858328843 no 329 0.055492310464625 394 6620925
SGTC_2063 5246145 200 µM 1.59256387496693 0.0815910425907666 no 330 0.0556290315221798 395 711240
SGTC_2570 licareol 100 µM 1.58641945974695 0.0823866635596763 no 331 0.0563220944788887 378 443158
SGTC_1504 k297-0033 30 µM 1.58578612228935 0.0824690033905427 no 332 0.0563939174135113 300 4388117
SGTC_1758 st042942 75.2445 µM 1.5812015923199 0.083066883781028 no 333 0.056915975706203 357 669317
SGTC_2932 9016711 44.54 µM 1.57831637281586 0.0834448205147265 no 334 0.0572464731829798 418 7117328
SGTC_2763 lisinopril 49.32 µM 1.57781046388347 0.0835112228099662 no 335 0.0573045795987497 327 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_134 0269-0018 6.916 µM 1.5732476923833 0.0841118974228922 no 336 0.0578307380037533 469 4378915
SGTC_195 4234-0266 16.654 µM 1.56925111747848 0.0846406936763943 no 337 0.0582947187691965 430 2303354
SGTC_1663 st014140 55.4 µM 1.56667431263804 0.0849829564661418 no 338 0.0585954189853685 440 4207120
SGTC_1391 3442-0225 151 µM 1.56542178603628 0.0851496968949713 no 339 0.0587420217117933 320 5227075
SGTC_3274 9138298 49.47 µM 1.56199605620652 0.0856069933114279 no 340 0.0591444589663658 418 17015756
SGTC_1727 st034309 9.9045 µM 1.56167555311245 0.0856498707608631 no 341 0.0591822203832058 479 870305
SGTC_1489 4065-0444 182 µM 1.56051011440368 0.0858059206759176 no 342 0.0593196908352069 363 2877968
SGTC_3102 9121669 49.47 µM 1.55954196108027 0.0859357162159334 no 343 0.059434080572993 316 41905072
SGTC_1475 4092-1048 11.7 µM 1.5593591057299 0.0859602472176775 no 344 0.0594557047910049 422 2881759
SGTC_3356 9151811 4.48 µM 1.55653741880755 0.0863394558675414 no 345 0.0597901759754867 382 1859254 YPR165W RHO1
SGTC_997 3996-0078 137 µM 1.55443404341911 0.0866229429038921 no 346 0.0600404590210795 410 735687
SGTC_1913 st060213 96.1 µM 1.55346028786386 0.0867544183006493 no 347 0.0601566047780628 436 688959
SGTC_2403 6032726 181.2 µM 1.55290247274109 0.0868298010290732 no 348 0.0602232179857385 398 2881040
SGTC_2943 9068529 45.32 µM 1.53995237650598 0.0885936518574209 no 349 0.0617859811588131 431 3270634
SGTC_1014 4130-3005 69.3 µM 1.53950714409868 0.0886547652687774 no 350 0.0618402675742842 429 743608
SGTC_599 1935-0052 86.5 µM 1.53901578930893 0.0887222459628182 no 351 0.0619002208188994 422 9557311
SGTC_1765 st044815 90.4 µM 1.53866254382953 0.0887707829087552 no 352 0.0619433505125601 404 645695
SGTC_3085 9117376 49.47 µM 1.52904282117179 0.0901001726384183 no 353 0.0631269143537297 399 16480349
SGTC_1365 1672-3266 55.4 µM 1.52273704502246 0.0909795844251509 no 354 0.0639122529558224 441 6415873
SGTC_2641 levomentholum 100 µM 1.52074334293963 0.0912589492594969 no 355 0.0641621286593326 325 16666
SGTC_1935 st074532 41.6 µM 1.51989816584302 0.0913775703453468 no 356 0.0642682857617216 493 2829742
SGTC_2667 digitoxin 100 µM 1.51461046486598 0.0921222976642632 no 357 0.0649355402317367 298 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_671 0560-0003 407 µM 1.51418028987485 0.0921830811984744 no 358 0.0649900596468741 400 3238678
SGTC_1770 st043884 66.3 µM 1.51219628476271 0.0924638044883735 no 359 0.0652419679504043 410 670149
SGTC_235 0330-0087 5 mM 1.51199941513669 0.0924916946662344 no 360 0.0652670056638943 441 46494818 YHR062C RPP1
SGTC_2008 4012253 172 µM 1.51125793699498 0.0925967944537581 no 361 0.0653613731466759 454 603940
SGTC_3338 9144300 39.5675 µM 1.51086626949544 0.0926523464631623 no 362 0.0654112631375756 417 4901274
SGTC_2812 7970281 58.44 µM 1.51030716887263 0.0927316889899373 no 363 0.0654825316655704 439 2233435
SGTC_721 1187-1332 279 µM 1.50661543606539 0.0932568481297474 no 364 0.0659546292273129 310 25730
SGTC_1512 0259-0544 12.2 µM 1.50207503450538 0.0939057419843348 no 365 0.0665388658021626 458 18476
SGTC_1685 st024049 53.0905 µM 1.50190621627049 0.0939299328224322 no 366 0.0665606655009334 369 1941139
SGTC_176 1486-1328 72.834 µM 1.50141379346518 0.0940005209053378 no 367 0.0666242842231946 465 22310231
SGTC_364 0083-0097 67.7 µM 1.50039725228615 0.0941463643826973 no 368 0.0667557654355105 417 5207356
SGTC_937 3122-0005 46.7 µM 1.49647285003627 0.0947109658639988 no 369 0.0672652389103933 443 759535
SGTC_2472 5377652 49.4 µM 1.49437496048967 0.0950138096900535 no 370 0.0675388212145497 473 1610903
SGTC_1240 0356-0016 42.1 µM 1.49171442080894 0.0953989008320534 no 371 0.0678870135008018 425 4305613
SGTC_228 caffeine 993.056 µM 1.49161091571658 0.095413905523402 no 372 0.0679005874644792 376 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2707 st078556 66.6 µM 1.49070291407921 0.0955456091154728 no 373 0.0680197553400753 394 17250899
SGTC_565 1418-0001 44.5 µM 1.49035408182751 0.0955962420042658 no 374 0.0680655796632529 465 2862145
SGTC_149 3970-0822 46.1 µM 1.48973407002464 0.09568628524829 no 375 0.0681470862900212 579 3114250 YBL034C STU1
SGTC_54 0159-0055 9 µM 1.48654130517331 0.0961509531595126 no 376 0.0685679999119152 428 3319099
SGTC_948 3448-0295 75.3 µM 1.48550392740729 0.0963022873049236 no 377 0.0687051919033594 487 678569
SGTC_1006 4099-6547 255 µM 1.48084428071755 0.0969842026458668 no 378 0.0693240368475974 435 3146833
SGTC_1441 4106-0040 13 µM 1.47760673277866 0.097460083805355 no 379 0.0697565356031598 417 2904180
SGTC_450 aminopyrene 156 nM 1.47733963632115 0.0974994201617357 no 380 0.0697923091184061 452 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3088 9117578 49.47 µM 1.471386968492 0.0983791170614971 no 381 0.0705932478055087 395 678341
SGTC_1189 1431-2119 7.28 µM 1.47074239526929 0.0984747210120068 no 382 0.070680398109961 469 3107275
SGTC_3120 9124077 49.47 µM 1.46851264295163 0.098805965473487 no 383 0.0709825122746054 431 18774327 YGL155W CDC43
SGTC_900 1112-0045 141 µM 1.46759500702706 0.0989425229240735 no 384 0.0711071325362214 326 56211 YIL048W NEO1
SGTC_2924 9010168 62.78 µM 1.46729884939777 0.0989866249060059 no 385 0.0711473882951023 466 2993929
SGTC_2176 5809774 33.9695 µM 1.46717534256695 0.099005021035847 no 386 0.0711641813530639 441 2870539
SGTC_1361 1608-0041 5.61 µM 1.46697335694614 0.0990351118355998 no 387 0.0711916516251708 454 X1361
SGTC_1276 0871-0068 94.2 µM 1.46398917593861 0.0994804598547889 no 388 0.0715984529172318 410 3414906
SGTC_3192 9110362 49.47 µM 1.4636629023849 0.0995292403271994 no 389 0.0716430382207291 444 16649480
SGTC_5 0352-0601 109.883 µM 1.46275006400758 0.0996658097397499 no 390 0.0717678908082252 379 762456
SGTC_2515 chrysin 20.77 µM 1.46137462626104 0.0998718469805355 no 391 0.0719563300681598 429 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2878 9043973 25.97 µM 1.45512134608973 0.100812496150077 no 392 0.0728178353096242 405 6465167
SGTC_1812 st052057 4.327 µM 1.45250878655864 0.101207397736719 no 393 0.0731800939174333 463 3645418
SGTC_1897 st060201 15 µM 1.45249471339939 0.101209528013945 no 394 0.0731820490347184 407 611878
SGTC_1353 1498-1206 8.11 µM 1.45047446398092 0.101515675591373 no 395 0.0734631275816386 521 6756808
SGTC_3005 9076496 71.4286 µM 1.44730802408768 0.101996872375279 no 396 0.0739053363871608 408 21368410
SGTC_1331 1472-0049 76.2 µM 1.44562671478058 0.102253050822199 no 397 0.074140964740164 434 24051409
SGTC_1238 0333-0287 48.8 µM 1.44420149581393 0.102470575429756 no 398 0.0743411521375392 454 7226
SGTC_3115 9123671 49.47 µM 1.44179676049597 0.102838361535466 no 399 0.0746798585212093 421 3286988
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.43590482816723 0.103743540109836 no 400 0.0755147122237661 477 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1896 st058441 89 µM 1.43528789428837 0.103838653021126 no 401 0.0756025379862576 420 688759
SGTC_1397 3532-0190 20.1 µM 1.43349217150799 0.104115860182462 no 402 0.0758586172725677 377 5322280
SGTC_2128 5255449 168.493 µM 1.43188094032402 0.104365043546655 no 403 0.0760889488871789 487 736008
SGTC_595 3909-8003 73.7 µM 1.41755732158717 0.106599265998899 no 404 0.0781600239030889 473 699517
SGTC_1863 st057641 20.1 µM 1.41678192856237 0.106721190709184 no 405 0.0782733474130679 503 3921635
SGTC_2658 polymyxin b sulfate 77.05 µM 1.41625271582257 0.106804463188509 no 406 0.0783507632462022 493 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_3298 9116858 71.43 µM 1.4155256838252 0.106918939281164 no 407 0.0784572116999167 479 2506942
SGTC_382 3229-0966 23.2 µM 1.41258320996416 0.107383155716739 no 408 0.0788891543365433 495 5722370
SGTC_1313 1220-0047 237 µM 1.41093799834707 0.107643343269289 no 409 0.0791314483389127 529 3528706
SGTC_1352 1496-0991 99 µM 1.40435032042242 0.108689724308742 no 410 0.0801072783513821 447 3000039
SGTC_3018 9082602 49.47 µM 1.40395349593517 0.108752988353452 no 411 0.0801663490062688 481 17332089
SGTC_742 0kpi-0133 140 µM 1.4027661716546 0.108942436559413 no 412 0.0803432888241674 497 2728852
SGTC_3178 9107506 49.47 µM 1.4020306601515 0.10905991293125 no 413 0.08045304562426 472 8897194
SGTC_3072 9116419 49.47 µM 1.40147176439448 0.109149240978736 no 414 0.0805365226308199 415 17170162
SGTC_2212 7123476 200 µM 1.40037365551385 0.109324904315972 no 415 0.0807007273727121 369 1085715
SGTC_71 0417-1750 47.813 µM 1.39994970547796 0.109392777473412 no 416 0.0807641899702139 512 6811472
SGTC_2010 4012422 159 µM 1.3998726725981 0.109405113460335 no 417 0.0807757253422078 483 952393
SGTC_708 3448-5400 146 µM 1.39945023541697 0.109472779993892 no 418 0.0808390057731201 510 3462195
SGTC_968 1309-0633 340 µM 1.39831751671879 0.109654368675059 no 419 0.0810088699941805 475 3761976
SGTC_418 lividomycin a 100 µM 1.39453930874301 0.110261625104874 no 420 0.0815774039110136 498 72394 An antibiotic.
SGTC_1849 st056239 19.2 µM 1.39338856992631 0.110447057065728 no 421 0.0817511601255871 503 5393181
SGTC_1722 st034304 3.6505 µM 1.3931079792162 0.110492305803212 no 422 0.0817935702939119 496 4036148 YLR033W RSC58
SGTC_224 benfluorex 43.875 µM 1.39201022999919 0.11066945919875 no 423 0.0819596500747257 359 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_401 neomycin 50 µM 1.39146049570926 0.11075825108406 no 424 0.0820429154559092 443 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3240 9133527 49.47 µM 1.38930597850896 0.11110673606032 no 425 0.0823698633505907 475 17617455
SGTC_2499 avocadenofuran 51.48 µM 1.38723614811665 0.111442262096946 no 426 0.0826848830915366 511 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2087 5276107 200 µM 1.3776048927284 0.113013056614399 no 427 0.0841626547545248 479 144405
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.36341694757525 0.115355699976847 no 428 0.0863755714417692 545 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2366 9070441 60.58 µM 1.36327349455398 0.115379561171457 no 429 0.0863981661103588 529 6837235
SGTC_2344 7990960 76.95 µM 1.36186588033435 0.115613882148826 no 430 0.0866201078622059 473 140813
SGTC_214 4373-3496 70 µM 1.36149336560963 0.115675949999566 no 431 0.0866789143591136 689 3779166
SGTC_3193 9111931 49.47 µM 1.3604478846102 0.115850272912343 no 432 0.0868441170797073 509 17087244
SGTC_745 0469-0705 296 µM 1.35893454442966 0.116102936718639 no 433 0.0870836655973711 570 3486736
SGTC_1155 4088-0394 48.2 µM 1.35082436718576 0.117463658149015 no 434 0.0883758502434904 517 2326248
SGTC_2591 skatole 100 µM 1.35001433644844 0.117600182365557 no 435 0.0885056921323491 490 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_72 0744-0168 198.391 µM 1.34824294378558 0.117899127766292 no 436 0.0887901282999971 504 677577
SGTC_2974 9094440 9.66 µM 1.34729368871743 0.118059547902457 no 437 0.0889428319810708 559 25236134
SGTC_620 0109-0052 432 µM 1.34494920001788 0.118456418052162 no 438 0.0893208201136433 510 493037
SGTC_1325 1431-0015 227 µM 1.34394871516701 0.118626064776954 no 439 0.0894824857150548 495 1103340
SGTC_2411 st077133 39.94 µM 1.34282122008158 0.118817453591347 no 440 0.0896649352540884 588 1403142 YNL221C POP1
SGTC_150 3970-0969 77.2 µM 1.34211125844152 0.118938079241779 no 441 0.089779961994006 604 6615640
SGTC_2062 5245942 200 µM 1.33963906431304 0.119358790846524 no 442 0.0901813585744423 544 1376160
SGTC_413 propylparaben 100 µM 1.33856106200826 0.119542570898448 no 443 0.0903568046800353 512 7175 A pharmaceutical preservative.
SGTC_2379 9035213 200 µM 1.33670477725768 0.119859501779351 no 444 0.0906595109682287 565 646551
SGTC_456 gingerol 170 µM 1.33654563125041 0.119886700955754 no 445 0.0906854980631312 513 442793 A herb.
SGTC_2835 9006588 71.43 µM 1.33424837686282 0.120279802756995 no 446 0.0910612349029016 530 2345538
SGTC_2513 baicalein 25.65 µM 1.33242567047693 0.120592346222534 no 447 0.0913601756746213 513 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2213 7173844 200 µM 1.33007370852717 0.120996486682545 no 448 0.0917469935236761 537 892728
SGTC_3187 9109394 49.47 µM 1.32932614251088 0.121125141207122 no 449 0.0918701964934584 550 17098090
SGTC_1530 rhein 70.4 µM 1.3246794713797 0.121926981451165 no 450 0.0926387423896598 557 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_230 MPP+ 141.667 µM 1.32402438380969 0.122040324047078 no 451 0.0927474733293713 514 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1473 k844-0725 134 µM 1.32125786651013 0.122519800090057 no 452 0.0932076987656676 593 54682906
SGTC_1824 st053723 68.6 µM 1.32110783668149 0.12254584008368 no 453 0.0932327052092706 527 675225
SGTC_878 0828-0289 13.7 µM 1.31551812654358 0.123518789155937 no 454 0.0941679147200456 593 745350 YLR208W SEC13
SGTC_3070 9117005 49.47 µM 1.31215651908685 0.124106511636004 no 455 0.0947336646165616 443 8779016
SGTC_3314 9135860 59.4275 µM 1.31185848936787 0.124158711555759 no 456 0.0947839428794082 549 25252478
SGTC_1768 st044301 37.178 µM 1.31061959539675 0.124375868522976 no 457 0.0949931577685479 552 3931349
SGTC_517 1365-0151 113 µM 1.30971301013699 0.124534945649349 no 458 0.095146470326565 523 768657
SGTC_2292 7671323 168.05 µM 1.30970510436768 0.124536333487899 no 459 0.095147808071545 549 937504
SGTC_1098 clofazimine 15.1 µM 1.30935856309593 0.124597178589265 no 460 0.0952064603592575 591 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_477 mead ethanolamide 10 µM 1.30866128519853 0.124719668368898 no 461 0.0953245556712056 357 16061185
SGTC_1380 2291-0730 164 µM 1.30450654541095 0.125451270034867 no 462 0.0960304646405292 493 2999191
SGTC_2589 lobaric acid 100 µM 1.30433919587017 0.125480800978512 no 463 0.0960589783965567 528 73157 A novel microtubule depolymerizer.
SGTC_23 0213-0011 39.996 µM 1.30367871806808 0.125597397999918 no 464 0.096171574297942 536 627608
SGTC_2150 5556613 200 µM 1.30313853368492 0.125692815282725 no 465 0.0962637351077474 581 743190
SGTC_2789 5281112 71.43 µM 1.30220224796502 0.125858319023941 no 466 0.0964236284696443 546 765948
SGTC_2077 5212015 200 µM 1.30179238689824 0.125930816447144 no 467 0.0964936835086855 525 780900
SGTC_665 3914-0008 307 µM 1.30150346806516 0.125981938750881 no 468 0.0965430890998834 540 1069549
SGTC_2951 9072950 58.06 µM 1.29726793382355 0.126733050298414 no 469 0.0972695067533919 579 16488155
SGTC_1870 st057514 26.5 µM 1.29672354589913 0.126829815407127 no 470 0.0973631623876198 544 5393161
SGTC_550 4123-0385 25.7 µM 1.2938311116956 0.127344809066045 no 471 0.0978618818486659 541 5731123
SGTC_1646 st011709 75.6 µM 1.29330866091371 0.127437985529824 no 472 0.0979521631829418 504 5757843
SGTC_3276 9139060 49.47 µM 1.29121615928959 0.127811647822652 no 473 0.0983143666433498 489 4870619
SGTC_2348 9022543 33.42 µM 1.2910051872804 0.127849363736293 no 474 0.0983509393978097 564 3162678 YDL140C RPO21
SGTC_3228 9131799 49.47 µM 1.28788871221286 0.128407403670481 no 475 0.0988923526599724 542 17015818
SGTC_46 0329-0187a 2.197 µM 1.28646432822301 0.128663017866825 no 476 0.0991405302395556 661 46494817
SGTC_766 1391-0721 126 µM 1.28599089023983 0.128748057263294 no 477 0.0992231204924824 557 1020919 YIL115C NUP159
SGTC_834 0312-0008 75.7 µM 1.27569942920301 0.130606261251628 no 478 0.101030895222353 591 6385573 YIL048W NEO1
SGTC_333 3486-0131 40.1 µM 1.27455759698643 0.130813565095224 no 479 0.101232937020412 564 6744690
SGTC_1108 betulinic acid 729.144 nM 1.27428630676938 0.130862852250717 no 480 0.101280983793342 575 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3223 9129970 49.47 µM 1.27279480094721 0.131134053579031 no 481 0.101545433281178 613 17248386
SGTC_248 streptozotocin 5.23457 mM 1.27230420215867 0.131223344221319 no 482 0.101632528067064 583 5300 DNA alkylating agent.
SGTC_1956 st077085 54 µM 1.26937218636679 0.131757856362386 no 483 0.102154175674376 600 24208685
SGTC_646 4092-0839 27.3 µM 1.26816272572716 0.131978780415131 no 484 0.102369922552943 569 877796
SGTC_3027 9089541 49.47 µM 1.26247235009939 0.133021631002153 no 485 0.103389434779031 592 9943819
SGTC_3309 9129340 25.759 µM 1.26116033597259 0.133262880683411 no 486 0.10362554293884 612 17158987
SGTC_2773 thioridazine 9.09 µM 1.26114431407679 0.133265828606579 no 487 0.103628428632038 594 5452 An antipsychotic.
SGTC_1947 st076332 61.6 µM 1.26009875334844 0.133458301895959 no 488 0.103816869973134 497 24208416
SGTC_3268 9137683 49.47 µM 1.25999515662973 0.133477383026762 no 489 0.103835554728295 525 1953228
SGTC_33 0986-0033 35.816 µM 1.25779313241706 0.133883410308861 no 490 0.104233290010688 530 2848082
SGTC_1843 st055809 45.5 µM 1.25616663548714 0.134183861675955 no 491 0.104527780342907 547 16413835
SGTC_1395 3486-0190 4.35 µM 1.25453157121154 0.134486362108057 no 492 0.104824428933067 617 6748079
SGTC_343 4130-2827 29.8 µM 1.25437939975064 0.134514538882851 no 493 0.104852068272569 606 1118244
SGTC_1467 k284-1082 293 µM 1.25306719610405 0.134757680754139 no 494 0.105090626549891 607 3334705
SGTC_1440 4100-1550 40 µM 1.25253734685594 0.13485594341404 no 495 0.105187064253004 526 742806
SGTC_2086 5274770 176.623 µM 1.24895294558496 0.135521975942697 no 496 0.105841142369244 568 689278
SGTC_946 3434-1334 87.4 µM 1.24553842619225 0.13615853495626 no 497 0.106466949899475 564 4047976
SGTC_1194 1488-0194 225 µM 1.23668213000026 0.137819114297266 no 498 0.108102557753959 628 1391452
SGTC_2461 5755302 26.15 µM 1.23219431500749 0.138665845326004 no 499 0.108938253216542 626 2788904
SGTC_1178 0988-0033 191 µM 1.23083453992294 0.138923096690992 no 500 0.109192377181789 613 5392207
SGTC_1891 st059073 26.2 µM 1.23052699177812 0.138981325741354 no 501 0.109249912876835 640 688754
SGTC_2984 9022109 38.96 µM 1.22973841685264 0.139130705009059 no 502 0.109397537935171 551 6459207
SGTC_2075 5212009 200 µM 1.22208526847664 0.140586112618594 no 503 0.1108376916965 536 780898
SGTC_3067 9117431 49.47 µM 1.22143502830523 0.140710244078803 no 504 0.110960675704973 550 17150885
SGTC_1162 k048-0130 20.1 µM 1.22027570312976 0.140931744817974 no 505 0.111180188594235 612 6797406
SGTC_439 amiodarone 34.4 µM 1.21669689838943 0.141617002877391 no 506 0.111859779797092 651 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1673 st016611 27.3 µM 1.21394146305688 0.142146140368781 no 507 0.112385039066262 624 5226799
SGTC_251 melphalan 456.522 µM 1.21220680240993 0.142479939809891 no 508 0.112716614116827 687 460612 A DNA alkylator.
SGTC_442 cape 100 µM 1.20759544699416 0.143369875808119 no 509 0.113601455694955 561 5281787
SGTC_2142 5622915 118.518 µM 1.20710152624166 0.143465418614337 no 510 0.113696523594816 569 5322196
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.2059794473958 0.143682630481465 no 511 0.113912707589808 643 5282309
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.20448174055761 0.143972902003843 no 512 0.114201717667828 629 688664
SGTC_1867 st057372 64 µM 1.20366843855664 0.144130694177458 no 513 0.114358877853173 610 688837
SGTC_2226 7298446 200 µM 1.20074565470495 0.144698718103123 no 514 0.114924939250842 570 3283010
SGTC_1825 st052143 62.6 µM 1.19637843688126 0.145550264479915 no 515 0.115774456084293 577 674173
SGTC_1499 4480-0877 67.3 µM 1.19600960437522 0.145622335662487 no 516 0.115846405551595 576 2861909
SGTC_2628 lathosterol 100 µM 1.19571825574595 0.145679283180344 no 517 0.115903262406262 628 6710616
SGTC_720 r052-1644 49.9 µM 1.19255456560073 0.146298627590598 no 518 0.116521934349469 550 1422863 YOR257W CDC31
SGTC_911 3456-4043 236 µM 1.19204676381264 0.146398202582098 no 519 0.116621454707276 662 914281
SGTC_187 1488-2104 32.728 µM 1.18936626894312 0.146924575448537 no 520 0.117147784130743 652 2852859
SGTC_1790 st045711 43.5 µM 1.18421667863293 0.147939366111681 no 521 0.118163650767081 628 585119
SGTC_227 fluconazole 33.516 µM 1.18395744496907 0.147990575065927 no 522 0.118214954330647 671 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_3308 9128332 17.569 µM 1.18352768153994 0.148075496564355 no 523 0.11830004123466 724 17332805 YDL196W YDL196W
SGTC_159 3970-0959 50 µM 1.18307859247578 0.148164271657612 no 524 0.118389000586308 853 6615653
SGTC_415 dibenzyl ketone 100 µM 1.18305449403365 0.148169036399519 no 525 0.118393775545561 659 7593
SGTC_2117 5521686 200 µM 1.18249040443289 0.148280597435198 no 526 0.118505585349007 631 803312
SGTC_2972 9093619 59.92 µM 1.18208285822537 0.148361233552603 no 527 0.118586412662701 615 25236256
SGTC_3066 9117245 49.47 µM 1.1814084984509 0.148494725171797 no 528 0.118720241788911 656 17176980
SGTC_1910 st062352 60.4 µM 1.18054042726935 0.14866668077373 no 529 0.118892670667931 631 2245730
SGTC_1613 st002381 52.1 µM 1.17750721369528 0.149268572695484 no 530 0.119496559998545 621 551167
SGTC_2210 7115885 190.385 µM 1.17604323561991 0.149559656715904 no 531 0.119788799669062 660 2927039
SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.17501435170027 0.149764457105159 no 532 0.119994487046708 645 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2407 paclitaxel 400 µM 1.17455012093853 0.149856923928673 no 533 0.12008737431405 680 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_372 0155-0182 15.9 µM 1.17199633277215 0.150366275600777 no 534 0.120599264247372 697 771486
SGTC_298 1391-0729 10 µM 1.16555448535446 0.151656217964681 no 535 0.121897309506917 616 3237558
SGTC_41 0478-0632 82.643 µM 1.1654555337462 0.151676089634354 no 536 0.12191732469578 736 3750424
SGTC_632 0781-2353 4.65 µM 1.16510612715337 0.151746272043507 no 537 0.121988018506643 680 6811515 YHR007C ERG11
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.1620732022845 0.152356377116263 no 538 0.122602865769994 578 6857784
SGTC_957 1187-1561 14.1 µM 1.15916518591888 0.152942882435435 no 539 0.123194429605296 663 1538454
SGTC_727 3032-0951 202 µM 1.15677267548788 0.153426538534358 no 540 0.123682624162431 613 3652836
SGTC_2418 pentamidine 31.67 µM 1.15595882531929 0.153591292465374 no 541 0.123848999596009 616 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1524 corynanthine 62.1 µM 1.15443939681229 0.153899195447368 no 542 0.124160035566667 637 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2177 5811945 192 µM 1.15417002521569 0.153953824568802 no 543 0.124215234498996 647 5343475
SGTC_3 0833-0587 95.581 µM 1.15377419099372 0.154034123853572 no 544 0.124296378969141 645 5382644
SGTC_512 prima-1 270 µM 1.15268198656143 0.154255833112622 no 545 0.124520468870942 686 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2201 6605497 169.863 µM 1.15168760322559 0.154457868873699 no 546 0.12472473411424 642 670741
SGTC_1038 k292-0204 154 µM 1.15029808628207 0.154740479548798 no 547 0.125010559381841 619 4454212
SGTC_2853 9015042 58.44 µM 1.14967440147889 0.15486744039485 no 548 0.12513900073559 615 6457456
SGTC_3057 9095946 49.47 µM 1.14568444832842 0.155681285805681 no 549 0.12596287045845 671 24540043
SGTC_368 fentichlor 4.58 µM 1.14522121171579 0.155775956295711 no 550 0.126058766848914 579 7329 A pesticide.
SGTC_2950 9072895 21.46 µM 1.14453898956888 0.15591544940811 no 551 0.126200088934998 672 17332245
SGTC_2360 9040895 200 µM 1.142899546438 0.156251000897238 no 552 0.126540150450134 602 4914414
SGTC_3198 9112019 49.47 µM 1.14244206448768 0.15634472042255 no 553 0.126635157454183 639 45595555
SGTC_2702 st077768 96.8 µM 1.13146552441474 0.158604468599972 no 554 0.128929603053278 613 6484119
SGTC_1762 st045503 25.4615 µM 1.12886223921294 0.159143535411985 no 555 0.129477976107261 674 4645554
SGTC_1862 st057513 3.81 µM 1.12858414230642 0.159201192293731 no 556 0.129536651655453 660 5393163
SGTC_2452 5863136 48.41 µM 1.12796690963204 0.159329209911706 no 557 0.129666947122986 665 2184096
SGTC_1208 2323-2347 50.3 µM 1.12656855868877 0.159619485240074 no 558 0.12996246937599 712 5412760
SGTC_2167 5876490 200 µM 1.12629653235267 0.159675993750911 no 559 0.130020012532444 688 686534
SGTC_2339 9000433 200 µM 1.11923882327934 0.161146679200817 no 560 0.1315191334532 605 2988954
SGTC_1966 st070145 16.1 µM 1.11694094446208 0.16162741239788 no 561 0.132009788216444 675 3748532
SGTC_3285 9112818 20.8695 µM 1.114514533766 0.162136049089997 no 562 0.132529256469201 737 17017947 YPR165W RHO1
SGTC_1521 st012942 49.4 µM 1.1135577659475 0.16233689791008 no 563 0.132734476752011 746 24207259
SGTC_1096 rimcazole 32.2 µM 1.10876553315151 0.163345340068794 no 564 0.133765671444197 662 18528119 A dopamine reuptake inhibitor.
SGTC_1923 st058458 19.1 µM 1.10667393439823 0.163786753687087 no 565 0.134217464398929 753 3534982
SGTC_1478 0453-0656 35.7 µM 1.10425066642111 0.164299130394125 no 566 0.134742208325275 695 5258496
SGTC_1058 3448-5425 97.3 µM 1.10355898025977 0.164445571239884 no 567 0.134892246666607 670 7279705
SGTC_3137 9097352 49.47 µM 1.10276160581718 0.164614492910862 no 568 0.135065352738682 743 44120435
SGTC_2193 5925765 200 µM 1.1003686907938 0.165122100408177 no 569 0.135585757141223 642 877370
SGTC_2910 7948405 25.97 µM 1.100236379501 0.16515019704667 no 570 0.135614571852285 649 2971328
SGTC_2518 prenyletin 46.28 µM 1.10002450483563 0.165195195614147 no 571 0.135660722586541 613 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1730 st033808 45.1 µM 1.09787834121947 0.165651451437805 no 572 0.136128808359295 794 1045166
SGTC_2476 5806916 10.51 µM 1.09654829533565 0.165934616278849 no 573 0.136419450184735 690 2870194
SGTC_2552 juarezic acid 87.02 µM 1.09546511326517 0.166165455155307 no 574 0.13665646069289 829 1549512
SGTC_3148 9097893 49.47 µM 1.09533189668644 0.166193859498116 no 575 0.136685629174805 661 17174100
SGTC_1795 st049545 62.3 µM 1.09127793355853 0.167059742352333 no 576 0.137575302205125 696 5291882
SGTC_511 blebbistatin 171 µM 1.08991030190063 0.167352508787049 no 577 0.137876329072981 699 3476986 A myosin inhibitor.
SGTC_2696 st077691 74.316 µM 1.08714545258028 0.16794538429962 no 578 0.138486266560867 639 757133
SGTC_2256 7954252 200 µM 1.08606904853575 0.16817656625089 no 579 0.138724222373052 609 2972920
SGTC_2445 5742597 35.57 µM 1.08423145056548 0.168571704568976 no 580 0.139131095132634 680 1774255
SGTC_129 0088-0017 176.636 µM 1.08365035569209 0.168696781388029 no 581 0.139259927433496 690 182446
SGTC_1670 st016595 4.04 µM 1.08302463694878 0.168831529873057 no 582 0.139398743859281 727 597879
SGTC_452 diindolylmethane 8 µM 1.08161507106571 0.169135333072296 no 583 0.139711802461145 662 3071 Inhibits expression of several cancer promoting factors.
SGTC_3056 9094900 49.47 µM 1.07824879541288 0.16986228440696 no 584 0.140461370670416 704 25236784
SGTC_755 1995-0008 37.3 µM 1.07621594819856 0.170302248973677 no 585 0.140915344413147 754 689533
SGTC_1680 diphenhydramine 100 µM 1.0743211185181 0.170712999458872 no 586 0.14133939150546 711 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_838 0109-0203 71.4 µM 1.07295042290104 0.171010526049622 no 587 0.141646680370702 753 759422
SGTC_1681 tripelennamine 100 µM 1.06989544168915 0.171674840559606 no 588 0.142333187558963 654 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_490 phenamil 164 µM 1.06953272362348 0.171753823995379 no 589 0.142414845838101 632 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_3255 9139072 49.47 µM 1.06663497795529 0.172385653894992 no 590 0.143068349618422 733 17646060
SGTC_3121 9125696 49.47 µM 1.06551848102128 0.172629492165769 no 591 0.143320683465947 730 1235365
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.06277994855042 0.173228506885413 no 592 0.143940877380056 757 2333 A French combination drug.
SGTC_3051 9093778 49.47 µM 1.06141890466403 0.17352670751327 no 593 0.144249784648119 679 17217378
SGTC_3306 9127676 59.7925 µM 1.05962475475625 0.173920299212638 no 594 0.144657673537613 704 41905287
SGTC_2659 sanguinarine 24.21 µM 1.05918611573712 0.174016611956571 no 595 0.144757513479702 720 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_520 3584-0023 682 µM 1.05801019162899 0.174274978954176 no 596 0.145025398012721 691 1340790
SGTC_2872 9044037 25.97 µM 1.0559672831008 0.174724413813637 no 597 0.145491581223138 711 6465195
SGTC_786 4544-0069 423 µM 1.05475160430038 0.1749922090541 no 598 0.145769471842111 772 748821 YLR208W SEC13
SGTC_1784 st039334 36.3 µM 1.05443369537996 0.175062282406219 no 599 0.145842201086636 735 3496984
SGTC_840 0245-0196 390 µM 1.05357513697025 0.175251614432713 no 600 0.146038738641214 800 3827528
SGTC_3146 9095609 49.47 µM 1.05112469683255 0.175792707143022 no 601 0.146600661318384 758 17173999
SGTC_1828 st055811 49 µM 1.05111270169235 0.175795358444 no 602 0.146603415548052 723 5877589
SGTC_1516 st013856 110 µM 1.04968532729971 0.176111033634901 no 603 0.146931405960383 719 5281404 A mutagen and neurotoxin.
SGTC_593 1203-0218 61.7 µM 1.04599900455602 0.176927951990639 no 604 0.147780745991265 790 3666956
SGTC_3355 9151058 44.0485 µM 1.03969111845555 0.178331374319072 no 605 0.149241714113403 739 17015728
SGTC_3035 9091303 49.47 µM 1.0344800583017 0.179496043016465 no 606 0.15045589734449 771 25237002
SGTC_1565 sinapyl alcohol 95.1 µM 1.03155844818886 0.180151107994478 no 607 0.151139507121709 723 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1421 4029-0249 71.4 µM 1.0313940950725 0.180188002742018 no 608 0.151178024405841 865 2894095
SGTC_208 k072-0098 12.366 µM 1.03080386972784 0.180320538351318 no 609 0.151316401609481 856 5948901
SGTC_797 k781-0471 270 µM 1.02919033852451 0.180683170265008 no 610 0.151695120723504 788 23738129
SGTC_13 0199-0087 65 µM 1.02510718694225 0.181602876122841 no 611 0.152656307388501 785 4589825
SGTC_2791 5663188 71.43 µM 1.02479403282659 0.181673532999779 no 612 0.152730191295895 744 54690634
SGTC_2762 leflunomide 42.06 µM 1.02272565336413 0.182140652802449 no 613 0.153218789302244 803 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3036 9090181 49.47 µM 1.02236856393224 0.182221373289904 no 614 0.153303246631891 773 25236586
SGTC_1442 4112-3290 3 µM 1.02116385765464 0.182493863481431 no 615 0.153588406350048 808 704353
SGTC_85 0868-0259 160.055 µM 1.0199977521476 0.182757864923429 no 616 0.153864763410973 747 83173
SGTC_2929 9013348 24.6 µM 1.01847530101561 0.183102900173026 no 617 0.154226066368475 731 2995952
SGTC_761 k216-0224 480 µM 1.01750333307902 0.183323391024161 no 618 0.154457023741302 853 1340404
SGTC_1934 st074720 32.6 µM 1.01448620226764 0.184008880895257 no 619 0.155175404972906 831 17250992
SGTC_1449 4112-4002 201 µM 1.01290463426722 0.184368848677691 no 620 0.155552857312657 740 2059539
SGTC_3182 9108849 49.47 µM 1.01279484032434 0.184393854232993 no 621 0.155579082873349 812 17133045
SGTC_1068 loratadine 26.9 µM 1.01196410762362 0.184583121860259 no 622 0.155777607558568 753 3957 A H1 histamine antagonist.
SGTC_2764 methyldopa 94.69 µM 1.01070677559293 0.184869812237805 no 623 0.156078396581838 820 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_117 lucigenin 22.078 µM 1.00897565243014 0.185264986557019 no 624 0.156493155542741 821 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2734 clemastine 41.6 µM 1.00763324439835 0.185571787246409 no 625 0.156815281569541 680 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_3239 9133757 49.47 µM 1.00553573464232 0.186051793440758 no 626 0.157319475709152 811 17036923
SGTC_487 nimodipine 119 µM 1.00317633071654 0.186592651934484 no 627 0.157887895515227 698 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2757 clomiphene 4.22 µM 1.00293844924685 0.186647236722239 no 628 0.157945279882903 884 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2998 9066762 71.4286 µM 1.00240652508774 0.186769328935317 no 629 0.158073645981878 819 4945196
SGTC_1021 4476-0760 85.3 µM 0.998711110296068 0.187618899166488 no 630 0.158967328492207 755 746768
SGTC_1624 st003710 6.25 µM 0.997075831458142 0.187995608125901 no 631 0.159363851627669 856 24207033
SGTC_2405 ticlatone 3.52 µM 0.996103146045511 0.188219900894492 no 632 0.159600015721196 776 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_730 1436-0052 41.2 µM 0.994237293028931 0.18865061224136 no 633 0.160053678067861 771 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_899 1083-0020 478 µM 0.994152689448907 0.188670156422733 no 634 0.160074268493836 823 767123
SGTC_89 0302-0250 142.109 µM 0.991781313596188 0.189218473079713 no 635 0.16065210751785 868 4203518 YLR208W SEC13
SGTC_2430 5571206 200 µM 0.991088388333851 0.189378878394614 no 636 0.160821211208585 906 1731771
SGTC_2926 9010726 65.15 µM 0.991029118747167 0.189392602599699 no 637 0.160835680940921 789 2994293
SGTC_1234 0326-0494 15.5 µM 0.99056286502869 0.189500587609987 no 638 0.160949539055477 817 1547813
SGTC_3277 9138724 49.47 µM 0.989575347565358 0.189729423092878 no 639 0.161190862283348 728 15943418
SGTC_645 0845-0943 5.41 µM 0.986429826047362 0.190459460770387 no 640 0.161961117477613 779 1885106
SGTC_3327 9140648 26.9345 µM 0.985351427072087 0.190710140713785 no 641 0.162225739927208 812 8029710
SGTC_290 2043-6722 48.1 µM 0.985169977851689 0.190752339504814 no 642 0.162270292414239 819 773758 YLR208W SEC13
SGTC_3334 9142812 21.919 µM 0.983725516460024 0.191088475425744 no 643 0.162625245125328 798 45283678
SGTC_2426 5582046 32.21 µM 0.981994902622306 0.191491678902661 no 644 0.163051179724262 836 2251934
SGTC_1952 st077036 64.1 µM 0.980937215794691 0.191738358312984 no 645 0.163311851803721 857 2937007
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.980936024148649 0.191738636344777 no 646 0.163312145643309 875 6708784 An antioxidant flavonoid
SGTC_1351 1496-0003 46.5 µM 0.98017116159041 0.191917143041538 no 647 0.163500818565762 857 3891978
SGTC_904 1141-0088 396 µM 0.978001316032422 0.192424103692425 no 648 0.164036836596386 787 1378119
SGTC_1759 st043059 70 µM 0.976033463586955 0.192884578172886 no 649 0.164523940798401 837 669426
SGTC_254 nsc-64875 3.808 µM 0.975266029230316 0.193064338921637 no 650 0.164714158306863 847 56993
SGTC_652 0437-0092 114 µM 0.975258440312044 0.193066117030049 no 651 0.164716040019454 802 3091274
SGTC_357 1325-0123 420 µM 0.971829710772585 0.1938705020975 no 652 0.165567636229481 815 1098503
SGTC_3050 9093513 49.47 µM 0.970506739707115 0.194181418422702 no 653 0.165896983555232 845 25236664
SGTC_2402 5553605 200 µM 0.970325110331222 0.194224127511451 no 654 0.165942232355101 856 6758546
SGTC_1227 3909-8010 46.6 µM 0.970204269806677 0.194252545625239 no 655 0.165972341422825 813 15982272
SGTC_278 4092-0821 23.9 µM 0.968085983959394 0.194751114894228 no 656 0.166500714592574 847 877900
SGTC_3049 9092223 49.47 µM 0.967356449159073 0.194923001528225 no 657 0.166682936708485 797 8623917
SGTC_73 0327-0325 16.231 µM 0.964467040807569 0.19560468449294 no 658 0.167405912495087 915 53298
SGTC_1698 5-fluorocytosine 1.055 µM 0.963375831957699 0.195862503767557 no 659 0.167679475125807 849 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3271 9137798 49.47 µM 0.962566811778777 0.196053783541182 no 660 0.167882479685683 767 6498326
SGTC_2113 5491891 107.031 µM 0.96176768882851 0.196242834469903 no 661 0.168083156027428 845 789979
SGTC_2264 7948757 110.76 µM 0.960308774647248 0.19658825916551 no 662 0.168449917590546 804 2971411
SGTC_930 2810-3379 265 µM 0.959625199083955 0.196750234874034 no 663 0.168621940964188 911 1015764
SGTC_1388 3346-4487 254 µM 0.953335328837577 0.198244432691752 no 664 0.170210098434711 899 3345614
SGTC_1697 st025554 27.742 µM 0.951888008805247 0.198589219485943 no 665 0.170576890766569 817 1269519
SGTC_3037 9091026 49.47 µM 0.951649205812101 0.198646142901691 no 666 0.170637458884096 934 25236398 YIL048W NEO1
SGTC_1769 st044406 64.4 µM 0.951365608460221 0.198713756718877 no 667 0.170709406172878 863 670903
SGTC_1839 st053978 48 µM 0.951220506743909 0.19874835648706 no 668 0.170746225290626 848 3788398
SGTC_2841 9004761 38.96 µM 0.949935515937186 0.199054923370832 no 669 0.171072509570439 772 2991039
SGTC_262 fenpropimorph 62.5 µM 0.948433370646122 0.199413658898441 no 670 0.171454438851429 799 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1668 st014914 51.6 µM 0.948417048764374 0.199417558952571 no 671 0.171458591776505 870 2839556
SGTC_1696 st025591 34.7925 µM 0.947672651684648 0.199595478721271 no 672 0.171648063831615 868 2787147
SGTC_284 0988-0104 32.6 µM 0.946976221208752 0.199762020362462 no 673 0.171825447967424 882 4666532
SGTC_417 st075190 100 µM 0.946619928854531 0.19984725502606 no 674 0.17191624256469 893 222757
SGTC_2638 epoxomicin 18 µM 0.943949867255288 0.200486701088428 no 675 0.172597633694768 911 9915668 A protesome inhibitor.
SGTC_91 0417-1751 58.384 µM 0.941840709542797 0.200992685397566 no 676 0.173137099630448 973 6795624
SGTC_3286 9117135 37.221 µM 0.941414768631421 0.201094960987701 no 677 0.173246174082716 817 3438150
SGTC_190 3970-0790 3.722 µM 0.940286576799281 0.201366009643552 no 678 0.173535291515701 845 2832352
SGTC_1557 sumaresinolic acid 42.3 µM 0.939318077264417 0.201598866732131 no 679 0.173783729997781 799 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2151 5563267 85.4165 µM 0.938561472973266 0.201780889869644 no 680 0.173977970656111 888 5310824
SGTC_1723 st034307 2.5525 µM 0.938197132343497 0.201868577685741 no 681 0.174071555910681 870 867466
SGTC_1149 3909-7961 23.3 µM 0.937023472157803 0.202151203865697 no 682 0.174373242118097 860 735261
SGTC_2914 7968218 45.32 µM 0.933710819704716 0.202950191586497 no 683 0.175226541152182 825 2977111
SGTC_1847 st056231 15 µM 0.932978592414973 0.203127053677915 no 684 0.175415510772792 920 5393180
SGTC_1338 1486-1223 76 µM 0.932551510984675 0.203230253347225 no 685 0.175525789477797 907 3444526
SGTC_2539 epi(13)torulosol 80 µM 0.932354462946124 0.203277878450788 no 686 0.175576684988925 836 6708597
SGTC_924 2046-0044 21.3 µM 0.932089176039746 0.203342006920028 no 687 0.175645220677586 898 3623589
SGTC_3012 9080433 71.4286 µM 0.93174116027612 0.203426151946559 no 688 0.175735154698663 927 17688859
SGTC_870 0573-2213 57.6 µM 0.929348085627749 0.204005324071795 no 689 0.176354361353096 850 3916321
SGTC_861 0443-0273 110 µM 0.928648075428905 0.204174926142051 no 690 0.176535749220421 896 6149169
SGTC_2956 9076196 2.52 µM 0.928397882908107 0.20423556443736 no 691 0.176600608157299 893 16423868
SGTC_2318 6029776 164 µM 0.926915287354438 0.204595116001651 no 692 0.176985259633341 870 818325
SGTC_2556 citropten 84.59 µM 0.923293203770883 0.205475107881569 no 693 0.177927214320115 956 2775 A potential DNA crosslinker.
SGTC_2252 omeprazole 400 µM 0.920729550773807 0.20609930822877 no 694 0.178595821965051 808 4594 A proton pump inhibitor.
SGTC_1857 st056007 79.3 µM 0.917286511275751 0.206939388994442 no 695 0.179496261885809 884 619834
SGTC_2908 7930301 100 µM 0.916732823403241 0.20707467437387 no 696 0.179641330846556 938 2223178
SGTC_3046 9092212 49.47 µM 0.915009812363534 0.207496001065316 no 697 0.180093239450247 873 25236637
SGTC_259 usnic acid 108.925 µM 0.913943789257613 0.207756928475178 no 698 0.180373191357686 907 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_485 niflumic acid 177 µM 0.913918778840759 0.20776305252898 no 699 0.180379762703692 858 4488 A COX2 inhibitor.
SGTC_905 2-aminofluorene 215 µM 0.913848433460512 0.207780277879303 no 700 0.18039824636108 943 1539 An established DNA mutagen. YPR165W RHO1
SGTC_40 0327-0103 19.753 µM 0.913790340218835 0.207794503705789 no 701 0.180413511593714 854 409036
SGTC_1486 3970-0793 4.53 µM 0.912260649505796 0.208169300105194 no 702 0.180815761888634 923 2844330
SGTC_567 1080-0542 68.4 µM 0.912105040438424 0.208207448924331 no 703 0.180856712616267 846 5950415
SGTC_661 1304-0007 33.6 µM 0.911105882823692 0.208452498744709 no 704 0.181119793555781 871 3117130
SGTC_1166 k206-0078 225 µM 0.910416417955681 0.208621693563468 no 705 0.181301471261573 917 5404595
SGTC_1562 morin hydrate 59.1 µM 0.908878488372286 0.208999393363209 no 706 0.181707134993429 868 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.907739145685332 0.209279463814669 no 707 0.182008028314983 965 6708561
SGTC_3331 9141060 1.957 µM 0.907450105783238 0.2093505500148 no 708 0.182084411471847 848 4906567 YPR165W RHO1
SGTC_3145 9085516 49.47 µM 0.906297794282636 0.209634089628729 no 709 0.182389126340012 857 25236195
SGTC_1036 k216-0215 33.5 µM 0.906213094436313 0.209654939915199 no 710 0.182411536754623 880 622330
SGTC_933 2914-0560 114 µM 0.90379520744145 0.210250657459474 no 711 0.183052001745779 957 463887
SGTC_2439 5492030 7.2 µM 0.903788102013473 0.21025240955416 no 712 0.183053885940988 900 5722370
SGTC_2341 7987486 176.74 µM 0.903752765616167 0.210261123120611 no 713 0.183063256516229 940 1258686
SGTC_123 0083-0120 66.675 µM 0.903455493542128 0.210334435536305 no 714 0.183142099556832 875 16001701
SGTC_1626 st003712 1.76 µM 0.903447899414451 0.210336308575625 no 715 0.183144113962619 836 24207035
SGTC_927 2425-1185 123 µM 0.902010192284578 0.210691085540142 no 716 0.183525726745979 872 730375
SGTC_776 4476-4378 112 µM 0.900541419057637 0.211053890819903 no 717 0.1839160968223 875 2892008
SGTC_2102 5377816 72.7585 µM 0.897301071712908 0.211855590864637 no 718 0.184779142387521 954 1379702
SGTC_1248 0469-0687 58.6 µM 0.896764413273652 0.211988538234995 no 719 0.184922320505081 916 4017482
SGTC_1484 3473-2379 286 µM 0.896360887047045 0.212088536651839 no 720 0.185030024928611 1094 671917
SGTC_3243 9134147 49.47 µM 0.896226591855199 0.212121822653463 no 721 0.185065878046521 966 24282180
SGTC_584 0986-0246 15.4 µM 0.895296376953946 0.212352466753271 no 722 0.185314338272739 1017 53315 YDR232W HEM1
SGTC_2191 5911152 200 µM 0.893968710527962 0.212681911533823 no 723 0.185669316292433 931 2875902
SGTC_1328 1441-0025 69.2 µM 0.891975179059122 0.213177142954529 no 724 0.186203118268352 865 4562601
SGTC_2770 toltrazuril 17.5 µM 0.891812014521803 0.213217705906466 no 725 0.18624685041687 952 68591 Kills coccidiodes.
SGTC_1804 st050076 49.1 µM 0.891493837745811 0.213296818081775 no 726 0.186332148000249 911 3895976
SGTC_3130 9127414 49.47 µM 0.89125298506427 0.213356715603494 no 727 0.186396732449213 911 1494646
SGTC_1080 nisoldipine 24.4 µM 0.891137672955482 0.213385395979643 no 728 0.186427658204806 929 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_578 3460-0051 92 µM 0.889928026943915 0.213686394013996 no 729 0.186752266795148 1025 2876744
SGTC_1645 Cervolide 78 µM 0.881750625855644 0.215727666579029 no 730 0.188955838609065 883 23173 A fragrance.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.880119103040079 0.216136281677062 no 731 0.189397395744874 912 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1223 0764-0573 147 µM 0.88003780342983 0.216156654892224 no 732 0.189419415359882 978 1609797
SGTC_277 nystatin 15.5 µM 0.879978405234979 0.216171540441582 no 733 0.189435504076113 992 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_506 n9-isopropylolomoucine 153 µM 0.879461848016077 0.216301017852326 no 734 0.189575455274391 949 6610355
SGTC_2059 5238311 157 µM 0.879323760034232 0.21633563783482 no 735 0.189612878317715 883 703021
SGTC_1991 st073000 8.92 µM 0.876597066648608 0.217019902730855 no 736 0.190352766516535 974 4301969 YIL048W NEO1
SGTC_1415 3966-0071 78.1 µM 0.874569823234804 0.217529449994982 no 737 0.190904006616468 934 2893185
SGTC_3216 9129716 49.47 µM 0.874488998915474 0.217549779477194 no 738 0.190926004330127 874 8056934
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.873770895994532 0.217730449750864 no 739 0.191121516530194 957 4213774
SGTC_1264 0783-0040 158 µM 0.871437819668734 0.218318034513863 no 740 0.19175757164447 896 2855798
SGTC_2818 7996756 12.99 µM 0.869143730057144 0.218896690211889 no 741 0.192384260238856 888 2241621
SGTC_2029 5175081 200 µM 0.869130664578362 0.218899988342021 no 742 0.192387832987677 1001 1380876
SGTC_2168 5727979 200 µM 0.868764411988414 0.218992453432738 no 743 0.192488001088721 886 695210
SGTC_2683 piperine 63.03 µM 0.868145058757901 0.219148868079236 no 744 0.192657463375661 917 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2967 9089538 49.85 µM 0.865180487280253 0.219898445137571 no 745 0.193469866738135 984 728216
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.864428185810138 0.220088894599784 no 746 0.193676357427863 990 5393153
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.864181571492473 0.220151347024513 no 747 0.193744077028085 996 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_728 3030-5151 22.5 µM 0.860879838399821 0.220988453820623 no 748 0.194652113487372 925 3125388
SGTC_1985 st071382 65.5 µM 0.859715596106273 0.221284064562964 no 749 0.194972917740428 1013 6123237
SGTC_2567 aureobasidin a 60 nM 0.859281021712875 0.221394464533196 no 750 0.195092746046965 915 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3354 9151612 71.43 µM 0.85912294973263 0.221434629200425 no 751 0.195136343465507 987 27261949
SGTC_2691 st077356 60.2 µM 0.858712784856383 0.221538867830687 no 752 0.195249497579439 986 2839272
SGTC_2871 9038510 12.99 µM 0.853590891180711 0.222842897257038 no 753 0.196665853640578 1018 4945164
SGTC_2373 9071805 200 µM 0.851919408462828 0.223269399830941 no 754 0.197129411926483 993 10149009
SGTC_476 mead acid 10 µM 0.847613330379303 0.224370294402142 no 755 0.198326673998401 949 5312531 An omega 9 fatty acid.
SGTC_472 calcifediol 10 µM 0.846100868890768 0.224757701181609 no 756 0.198748238035964 901 5283731 A vitamin D metabolite.
SGTC_696 1560-0013 611 µM 0.842914341996196 0.225575148673105 no 757 0.199638175907037 982 1650269
SGTC_2558 carylophyllene oxide 100 µM 0.841875593857193 0.225841984440607 no 758 0.199928796428831 1067 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2587 piperic acid 92.2 µM 0.840273745534008 0.226253820224643 no 759 0.200377459217895 906 5370536
SGTC_1432 4049-0298 68.4 µM 0.838262992107738 0.226771385713511 no 760 0.200941507858112 990 741646
SGTC_1316 1272-0050 65.9 µM 0.837799652504047 0.226890743395666 no 761 0.201071616978512 984 7340392
SGTC_2290 7904846 200 µM 0.83540849301416 0.227507276301395 no 762 0.201743874764805 972 2962154
SGTC_3154 9100113 49.47 µM 0.835293304918431 0.22753700002501 no 763 0.201776293039956 980 25237525
SGTC_2747 doxorubicin 7.63 µM 0.834898349663425 0.227638932895724 no 764 0.201887472029884 822 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3307 9126885 69.2785 µM 0.834448454851132 0.227755076274841 no 765 0.202014161050243 976 24824909
SGTC_607 4491-0986 66.8 µM 0.832620758432504 0.228227251235918 no 766 0.202529323928613 1019 698981 YDR232W HEM1
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.830986457900152 0.228649929100678 no 767 0.20299063979922 984 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1266 0828-0227 32.9 µM 0.830647828351205 0.228737563541366 no 768 0.203086303568136 956 3913820
SGTC_3256 9138902 49.47 µM 0.830391773343134 0.228803840913313 no 769 0.203158657673373 1043 17228773
SGTC_1007 4101-0031 70 µM 0.829698835486142 0.228983255251599 no 770 0.203354540014695 1020 1146276
SGTC_1075 aripiprazole 15.2 µM 0.8264290301847 0.229830932139374 no 771 0.204280380640636 1054 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1460 k062-0059 9.15 µM 0.825991092374897 0.229944598083263 no 772 0.204404572403422 1008 1373085
SGTC_1741 st038134 10.228 µM 0.823919642308509 0.23048266527521 no 773 0.204992609412664 1054 1272587
SGTC_2385 9074692 200 µM 0.823308011757 0.230641673157354 no 774 0.205166429367289 973 17046906
SGTC_1940 st075990 51.1 µM 0.822532255602481 0.230843437525928 no 775 0.20538701829689 1082 1084979
SGTC_1419 3993-2473 62.6 µM 0.822481896621086 0.230856538666425 no 776 0.20540134291358 1019 704026
SGTC_2207 7258803 200 µM 0.820651676267371 0.231332961292942 no 777 0.205922351790368 978 3666799
SGTC_830 4076-0286 57.8 µM 0.818862986178766 0.231799102594685 no 778 0.206432294925057 1099 6866659
SGTC_657 3534-0529 86.7 µM 0.817974387758843 0.232030870048316 no 779 0.206685906101991 1038 1049549
SGTC_2357 9067248 200 µM 0.817414249141555 0.232177033700212 no 780 0.206845867695719 972 9150235
SGTC_1764 st044502 93.5 µM 0.817275247588557 0.232213312967944 no 781 0.206885574412166 1016 8407
SGTC_18 0111-0177 500 nM 0.815768301312228 0.232606826877413 no 782 0.207316333115278 1108 721752
SGTC_34 0469-0683 81.75 µM 0.81495579121482 0.232819154083351 no 783 0.20754880799292 1032 3690923
SGTC_3278 9139605 49.47 µM 0.813554178990978 0.233185679936294 no 784 0.207950198300816 988 7958859
SGTC_2221 6807166 181.081 µM 0.81254828072712 0.233448922685381 no 785 0.208238547290854 987 674925
SGTC_2701 st077767 14.721 µM 0.810691113868132 0.233935374581311 no 786 0.208771538836709 1040 5721188
SGTC_44 0929-0055 61.211 µM 0.810073029172557 0.234097395362162 no 787 0.20894910217955 978 1379590
SGTC_3147 9097027 49.47 µM 0.809722160792376 0.234189397405941 no 788 0.209049939202135 1050 25236841
SGTC_404 fumagillin 50 µM 0.809152625622872 0.234338779207203 no 789 0.209213680470709 1032 12015870 A methionine aminopeptidase binder.
SGTC_2748 diazoxide 86.69 µM 0.807105102088691 0.234876253821953 no 790 0.209802966441893 952 3019 A potassium channel activatior.
SGTC_1977 st070720 65.3 µM 0.80708279293401 0.234882113721298 no 791 0.209809392480476 970 682188
SGTC_2094 5332512 191.667 µM 0.806910816626471 0.23492728909303 no 792 0.20985893326526 1070 755774
SGTC_1629 st005085 44.9 µM 0.805686126043551 0.235249134140296 no 793 0.210211925598628 1021 24207091
SGTC_3113 9123498 49.47 µM 0.80457817120274 0.235540511004201 no 794 0.210531571450334 1107 8897275
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.804420535669145 0.235581983152247 no 795 0.210577072594883 990 4620898
SGTC_677 0929-0063 136 µM 0.804290242344201 0.235616264911192 no 796 0.2106146858277 985 1539583
SGTC_3351 9150312 21.596 µM 0.802976634697177 0.23596204474493 no 797 0.210994119820496 1015 4904905
SGTC_1904 st060225 78 µM 0.802013616133127 0.23621571686873 no 798 0.211272540979796 1010 66595
SGTC_3112 9123419 49.47 µM 0.800880372751322 0.236514420778855 no 799 0.211600451856795 1096 17015854
SGTC_2323 6148992 148.28 µM 0.800575438021708 0.236594831926224 no 800 0.211688737422779 952 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2937 9044753 11.33 µM 0.796805262585663 0.237590267087987 no 801 0.212782069133517 1096 6465530 YGL099W LSG1
SGTC_1367 1812-0510 76.9 µM 0.79676397982215 0.237601179635372 no 802 0.212794059141861 1031 1142582 YDR527W RBA50
SGTC_1135 dihydrocapsaicin 536.708 nM 0.796509873069887 0.237668355419259 no 803 0.212867869622289 969 107982 A Capsaicinoid.
SGTC_793 0488-0545 106 µM 0.795103539947138 0.238040322675421 no 804 0.213276637824749 1017 292548
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.794987103363231 0.238071133798066 no 805 0.213310502068986 1030 4330530
SGTC_2018 5133068 143 µM 0.792594267149693 0.238704803176792 no 806 0.214007124943056 992 785362
SGTC_1669 st015249 58.4 µM 0.79161460541933 0.23896450259032 no 807 0.214292714045174 1148 722793
SGTC_356 1634-0012 32.5 µM 0.790288598098421 0.239316260998222 no 808 0.214679622035235 1075 735457
SGTC_571 k831-0106 44.2 µM 0.788864481360648 0.239694360320176 no 809 0.215095608592849 1015 4783639
SGTC_992 3909-8734 162 µM 0.788863050928195 0.239694740260119 no 810 0.215096026659361 1069 4288319
SGTC_2832 7992762 51.95 µM 0.788580489725698 0.239769798334206 no 811 0.215178618890589 941 2985177
SGTC_1307 1187-1599 12.2 µM 0.788001169291248 0.239923726063149 no 812 0.21534801096543 1062 1538471
SGTC_2466 5983409 37.09 µM 0.786841971594889 0.240231891219757 no 813 0.215687190132589 1003 2879657
SGTC_2243 6634756 200 µM 0.786619383420921 0.240291089511675 no 814 0.21575235446023 1028 885676
SGTC_1093 fluphenazine 7.97 µM 0.784990811927615 0.240724456896382 no 815 0.216229477844101 1133 6602611 An atypical antipsychotic.
SGTC_2892 9047358 58.44 µM 0.783646309968753 0.241082552884058 no 816 0.216623837201385 1016 6466771
SGTC_3127 9126946 49.47 µM 0.783306212874618 0.241173180558025 no 817 0.216723657852475 939 27243249
SGTC_2153 5569715 200 µM 0.781915638968556 0.241543927553594 no 818 0.217132076737968 1053 2054701
SGTC_1518 st038567 90.8 µM 0.78156022883807 0.241638734639908 no 819 0.217236533871924 1098 77966
SGTC_289 k017-0060 526 µM 0.780296484664601 0.241976007066666 no 820 0.21760819074762 1081 5512909
SGTC_1485 3909-9022 254 µM 0.778696474864179 0.242403389265512 no 821 0.218079266576911 1113 714516
SGTC_2694 st077685 81.9 µM 0.778410781160504 0.242479744558642 no 822 0.21816344249403 1072 2838096
SGTC_1041 0206-0046 107 µM 0.777819942048031 0.242637695184799 no 823 0.218337584911231 1044 50494
SGTC_1127 asiatic acid 681.4 nM 0.776495345838532 0.242992005442021 no 824 0.218728283886989 1017 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2361 9034121 116 µM 0.775738468556088 0.243194584704125 no 825 0.218951710690737 1052 6496917
SGTC_2844 9010103 25.97 µM 0.77222320560058 0.24413664538936 no 826 0.2199911198382 1039 2480525
SGTC_1057 3448-5381 134 µM 0.771697846676277 0.244277605963613 no 827 0.220146703192657 1099 5497911
SGTC_1455 4262-0120 131 µM 0.770739249985184 0.244534922836092 no 828 0.220430751085736 1090 1529587
SGTC_1462 k081-0014 26.5 µM 0.76989861157635 0.244760696181386 no 829 0.220680018791119 905 3270634
SGTC_1267 0828-0272 9.49 µM 0.76988620038858 0.244764030340091 no 830 0.220683700189275 1100 745334
SGTC_947 3447-0010 211 µM 0.76668970292812 0.245623555356295 no 831 0.221633013649372 1130 748350
SGTC_1534 6-azauridine 81.6 µM 0.765293053866946 0.245999616808841 no 832 0.222048529663809 1149 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_378 3970-0959 8.33 µM 0.765257317803188 0.246009243145924 no 833 0.22205916730514 1066 6615653
SGTC_2121 5257820 149.641 µM 0.763106248474938 0.246589055559189 no 834 0.222700016937949 1151 791256
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.761771719083226 0.246949140399316 no 835 0.223098131109304 1095 2724 A muscle relaxant with antifungal properties.
SGTC_802 4112-3352 742 µM 0.761577745693947 0.247001502019047 no 836 0.223156030580307 1120 704594
SGTC_2971 9092186 9.93 µM 0.761025788090774 0.247150531211075 no 837 0.223320832210406 1036 25236400
SGTC_163 TUB2.036 7.546 µM 0.758035287563992 0.247958805251571 no 838 0.224214929006923 1156 15992207 YJR013W GPI14
SGTC_454 lyso-paf C-16 6.67 µM 0.756822860652092 0.248286902059375 no 839 0.224577997456088 1083 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1461 k072-0203 53.8 µM 0.753910265125681 0.24907602920763 no 840 0.225451553151676 1088 5418714
SGTC_218 alverine citrate 93.75 µM 0.753790438020459 0.24910852324298 no 841 0.225487533258745 1066 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_212 3807-4682 38.772 µM 0.753693151778387 0.249134906433312 no 842 0.225516747482399 1213 3125501 YBL034C STU1
SGTC_1020 4335-0961 93.3 µM 0.753347044227693 0.249228779866252 no 843 0.225620697975976 1017 669075
SGTC_864 0469-0573 172 µM 0.752824371031953 0.249370578169405 no 844 0.225777729853197 1088 689425
SGTC_3203 9113543 49.47 µM 0.751010923886576 0.249862888523054 no 845 0.226323040783428 1088 17018012
SGTC_1799 st045822 46.1415 µM 0.750507385954131 0.249999679274407 no 846 0.226474588548261 1110 3674992
SGTC_1242 0402-0103 60.1 µM 0.749464196992136 0.250283197627782 no 847 0.226788735134917 1087 432868
SGTC_1254 0550-0035 264 µM 0.747295328153842 0.250873198993585 no 848 0.227442655961596 1131 15121435
SGTC_2400 5203494 178.7 µM 0.746420517585352 0.251111383512947 no 849 0.227706714402044 1085 6777674
SGTC_1902 st060212 70.5 µM 0.745497261047735 0.251362888092306 no 850 0.227985583155541 1167 688944
SGTC_1999 st074831 12.5 µM 0.744856558164303 0.251537500383123 no 851 0.228179219710694 1078 17112523
SGTC_890 0929-0006 47.2 µM 0.744576591374698 0.251613820518287 no 852 0.228263861750241 1122 1378169
SGTC_3058 9093861 49.47 µM 0.744074517345933 0.251750718661667 no 853 0.228415697413493 1117 17217477
SGTC_1493 4348-0038 111 µM 0.743928940246402 0.251790419832639 no 854 0.228459732996867 1169 800424
SGTC_1315 1237-0019 3.69 µM 0.743533220807732 0.251898355467783 no 855 0.228579458179991 1127 825140
SGTC_2035 5154463 94.595 µM 0.739744424733183 0.252933014872913 no 856 0.229727543293844 1121 2769623
SGTC_3000 9075062 71.4286 µM 0.739324224283088 0.253047902496449 no 857 0.229855071531827 1076 17057871
SGTC_2154 5570129 200 µM 0.735457283189747 0.254106456079584 no 858 0.231030523115179 1164 673366
SGTC_668 1682-0499 62.6 µM 0.734536433573227 0.254358875512175 no 859 0.231310931764131 1154 682214
SGTC_48 0382-0018 55 µM 0.734400677870272 0.254396099408751 no 860 0.231352286891185 1226 762596
SGTC_2074 5212007 75.395 µM 0.734133985469984 0.254469234154483 no 861 0.231433541142496 1078 758611
SGTC_1483 3453-0561 55.9 µM 0.73298013473182 0.254785780195338 no 862 0.23178527280296 1133 4546991
SGTC_2957 9076800 11.52 µM 0.731696100139672 0.255138282911492 no 863 0.232177038637577 1084 16459615
SGTC_341 1486-1430 230 µM 0.731506957491961 0.255190229300798 no 864 0.232234778197229 1132 2054753 YPL210C SRP72
SGTC_1309 pyrazolanthrone 13.4 µM 0.730421078573344 0.255488563520191 no 865 0.232566418928207 1158 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_133 0724-0033 378.92 µM 0.728768112210602 0.255943048834548 no 866 0.23307176021939 1056 280309
SGTC_1846 st056244 14.8 µM 0.722430565078313 0.257689467326125 no 867 0.235014900333773 1151 5393182
SGTC_2026 5148700 152 µM 0.721042365780456 0.258072833492646 no 868 0.235441724603696 1150 79838
SGTC_2349 9023730 187.07 µM 0.720143396042732 0.25832125134531 no 869 0.235718355405683 1143 4126287
SGTC_2553 4-methylesculetin 85.09 µM 0.720099109209225 0.258333492601106 no 870 0.235731987972899 1185 5319502
SGTC_1386 3228-0095 33.8 µM 0.719978410468488 0.258366856281044 no 871 0.235769144195397 1132 870181
SGTC_2580 diallyl disulphide 81.36 µM 0.717972963163835 0.258921530804017 no 872 0.236386978790504 1135 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_489 paxilline 115 µM 0.717245603732907 0.259122858864451 no 873 0.23661128243115 1162 105008 A toxic potassium channel blocker.
SGTC_579 4491-1009 110 µM 0.715081375251606 0.259722380668292 no 874 0.237279380863928 1314 1271041
SGTC_1354 1498-1681 81 µM 0.714072978316636 0.26000196512323 no 875 0.237591026989465 1197 5754243
SGTC_1932 st074806 40.9 µM 0.712260882724796 0.260504769891913 no 876 0.238151621083871 1277 17251235
SGTC_1960 st011366 51.8 µM 0.712046690923686 0.260564235069927 no 877 0.238217931821435 1209 3972846
SGTC_2447 5741742 33.78 µM 0.706671350013294 0.262058853575879 no 878 0.23988536888633 1194 1776504
SGTC_784 4579-0127 173 µM 0.705818667686682 0.262296345867333 no 879 0.240150455735364 1220 1948547
SGTC_756 0508-1999 28.3 µM 0.705113626425261 0.26249279984175 no 880 0.240369763605433 1167 6753853
SGTC_1404 3909-7820 48.3 µM 0.702514647071807 0.263217634180646 no 881 0.241179135287738 1165 23741373
SGTC_1332 1480-0653 17.5 µM 0.702478078996607 0.263227840010295 no 882 0.241190533841612 1177 5749438
SGTC_2123 5259487 200 µM 0.701583381399484 0.263477605232109 no 883 0.24146950925606 1164 2173474
SGTC_1906 st060206 94.7 µM 0.700520932178358 0.263774357296285 no 884 0.241801018762873 1195 5133468
SGTC_2335 9018011 154.17 µM 0.699461433635256 0.264070454848401 no 885 0.242131853384342 1221 6458208
SGTC_2148 5546263 113.568 µM 0.695552858575368 0.265164245262589 no 886 0.243354448695263 1170 792097
SGTC_583 1488-1091 88.9 µM 0.691707396540185 0.2662426147129 no 887 0.244560550525509 1296 4303273
SGTC_59 0330-0160 1.33 µM 0.68996144241549 0.266732958232878 no 888 0.245109217560771 1213 4293482
SGTC_2536 dehydroabietamide 32.04 µM 0.689729473818364 0.266798139924842 no 889 0.245182163608293 1215 3983547
SGTC_2697 mebhydrolin 72.4 µM 0.689332667646871 0.266909658579001 no 890 0.245306972392914 1201 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2248 tofa 1.1 µM 0.688967652267885 0.267012263518283 no 891 0.24542181206264 1147 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2979 9012552 45.46 µM 0.687238220369212 0.26749867324794 no 892 0.245966311455313 1251 17100905
SGTC_788 1182-0090 188 µM 0.686846027860102 0.267609041100855 no 893 0.246089880595275 1274 5715185
SGTC_1617 st002906 78 µM 0.686546286107362 0.267693407633635 no 894 0.2461843434739 1216 5150859
SGTC_812 4251-0442 148 µM 0.686097693374159 0.267819695405483 no 895 0.246325752692805 1203 5723007
SGTC_2822 7994718 71.43 µM 0.6851086380891 0.268098240125215 no 896 0.24663768488291 1166 1018011
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.684553503912867 0.26825464479003 no 897 0.246812857961483 1222 4174840
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.683197126458551 0.268636986418198 no 898 0.247241144087535 1215 7104
SGTC_1037 k284-1091 78.7 µM 0.681095472214426 0.269229950322767 no 899 0.247905540933445 1199 3334711
SGTC_3275 9138069 49.47 µM 0.680702667753548 0.269340849542605 no 900 0.248029823983326 1229 17617007
SGTC_2585 alliin 100 µM 0.679356534921923 0.269721072564549 no 901 0.248455991494798 1296 87310 A garlic compound which reacts with lipids.
SGTC_2394 5221648 200 µM 0.67759184716113 0.270219925722529 no 902 0.249015258401235 1281 788586
SGTC_74 000s-0487 160.283 µM 0.675267463244533 0.270877700679607 no 903 0.249752925846052 1187 677548
SGTC_363 0455-0021 3.06 µM 0.675124513442314 0.270918179961276 no 904 0.249798330299336 1248 4597466
SGTC_1349 flufenamic acid 69 µM 0.674490759476595 0.271097677244442 no 905 0.249999679274407 1200 3371 A non-steroidal anti-inflammatory.
SGTC_2304 7443016 91.4 µM 0.674441095413074 0.271111746035988 no 906 0.250015461603884 1187 939854
SGTC_2362 9071156 126 µM 0.6713578628888 0.271985873688557 no 907 0.250996290711341 1238 653133
SGTC_2022 5136654 200 µM 0.669918099807127 0.272394540662387 no 908 0.251455000444632 1229 1713771
SGTC_37 0566-0070 1.56 µM 0.669456035263341 0.272525759163387 no 909 0.251602308449234 1245 1626686
SGTC_850 0388-0143 75.9 µM 0.669173784844669 0.272605928937605 no 910 0.251692313422465 1208 67273
SGTC_2933 9026794 32.47 µM 0.668994184319096 0.272656948360792 no 911 0.251749593899976 1241 17586027
SGTC_983 1491-0821 12.2 µM 0.667648660498943 0.273039324248271 no 912 0.252178944286258 1208 46495113
SGTC_2239 6685329 187.64 µM 0.666554835310245 0.273350367256474 no 913 0.252528263182345 1245 805680
SGTC_2817 7995342 71.43 µM 0.66643037757349 0.273385769501618 no 914 0.252568025571272 1204 18879975
SGTC_2093 5331342 194.4 µM 0.666399611045186 0.273394521450377 no 915 0.252577855526211 1238 33839
SGTC_3001 9076041 71.4286 µM 0.664845890574655 0.27383667825148 no 916 0.253074533673291 1254 16004211
SGTC_188 3229-0966 278.469 µM 0.663834971161821 0.274124554816859 no 917 0.253397970186343 1335 5722370
SGTC_3191 9110352 49.47 µM 0.663035290846374 0.274352383303031 no 918 0.253653976064935 1244 17122424
SGTC_1011 4112-3381 17.4 µM 0.662523206144619 0.2744983250337 no 919 0.253817983758552 1288 2877139
SGTC_2187 6125751 200 µM 0.659131836229244 0.275465815312743 no 920 0.254905556787803 1238 874498
SGTC_732 3970-1727 52.7 µM 0.657735969812519 0.275864514927567 no 921 0.255353902407357 1264 1275699
SGTC_1335 1486-0900 202 µM 0.656498268751803 0.276218274947609 no 922 0.255751790555453 1266 X1335
SGTC_2129 girgensonine 121.053 µM 0.654738302542266 0.276721691967084 no 923 0.256318129994283 1300 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3015 9080845 49.47 µM 0.653371753341552 0.27711288660056 no 924 0.256758322190937 1305 5296973
SGTC_25 0118-0223 35.662 µM 0.653217902889329 0.277156945478526 no 925 0.256807905062423 1302 5333628
SGTC_292 k038-0015 474 µM 0.652857912264583 0.277260051078112 no 926 0.256923942189171 1257 46368540
SGTC_1302 1159-0335 255 µM 0.652643833658176 0.277321374633282 no 927 0.25699295988147 1271 649284
SGTC_2745 rifampicin 24.3 µM 0.652538277097983 0.277351614115319 no 928 0.257026994249844 1194 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1117 retinoic acid 1.10837 µM 0.652088476735896 0.277480489453794 no 929 0.257172048663065 1279 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1132 3456-3614 2.5 µM 0.651868680926372 0.277543475279047 no 930 0.257242945258196 1314 3125502
SGTC_2005 4024620 188 µM 0.651690624650433 0.277594505129369 no 931 0.257300385938329 1264 236743
SGTC_96 0929-0093 37.281 µM 0.651308765734814 0.277703959037097 no 932 0.257423595510765 1239 6991579
SGTC_3134 9127454 49.47 µM 0.651066715844863 0.277773349779753 no 933 0.257501710549071 1342 24262820
SGTC_3294 9122953 26.2835 µM 0.650359682164101 0.277976090318546 no 934 0.257729956989626 1258 16459826
SGTC_2483 5729050 27.16 µM 0.649928979429343 0.278099628876014 no 935 0.257869049016584 1311 2865180
SGTC_2194 5927483 104.545 µM 0.648340048272711 0.278555613849424 no 936 0.25838251841734 1279 760979
SGTC_2163 5671233 125 µM 0.648242285409494 0.278583681324656 no 937 0.258414128164621 1334 701023
SGTC_1434 4073-0095 163 µM 0.647526117456929 0.278789333357651 no 938 0.25864574841882 1269 24133745
SGTC_2923 7992654 58.14 µM 0.646847853502723 0.278984169126115 no 939 0.258865208967508 1298 2985126
SGTC_2072 5231554 129 µM 0.646375813959298 0.279119804654886 no 940 0.259017999939345 1321 789545
SGTC_22 0964-0034 14.468 µM 0.645895272995715 0.279257915899827 no 941 0.259173590565652 1245 138402
SGTC_225 nsc-122657 1.016 µM 0.644702124194645 0.279600979762719 no 942 0.259560119748177 1248 275685
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.644646147228406 0.279617079738935 no 943 0.259578261198353 1296 229346 A bile salt which induces apoptosis.
SGTC_653 0203-0016 55.2 µM 0.644098700289653 0.279774558982022 no 944 0.259755716559487 1307 295302
SGTC_3008 9078912 71.4286 µM 0.641220994342933 0.280603070174069 no 945 0.260689555641219 1266 16648731
SGTC_1045 1348-1485 165 µM 0.634560644682066 0.282525171132395 no 946 0.262857501274901 1302 6810614
SGTC_1273 0849-0096 14.1 µM 0.632618294962695 0.283086900992931 no 947 0.263491468513693 1288 5286025
SGTC_2620 irigenin 100 µM 0.631196406023909 0.283498452483397 no 948 0.263956055807636 1348 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1895 st058434 18.3 µM 0.630294033220707 0.283759783885373 no 949 0.264251113062656 1291 5393175
SGTC_2051 5263410 176 µM 0.629760426663405 0.283914373104965 no 950 0.264425670368455 1340 227584
SGTC_1463 k081-0032 34.1 µM 0.628813614378746 0.284188769823443 no 951 0.264735542960507 1193 977755
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.628786708198202 0.28419656938608 no 952 0.264744351508964 1189 88881 An O-methylated flavonoid and antioxidant.
SGTC_2543 pimpinellin 60.67 µM 0.62871806958017 0.284216466809753 no 953 0.264766823102562 1247 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2105 5350118 200 µM 0.626929604474865 0.284735153719711 no 954 0.265352690247528 1300 2133313
SGTC_2204 7233102 200 µM 0.626641294025237 0.284818811180696 no 955 0.265447196813632 1250 2172480
SGTC_2644 guaiazulene 100 µM 0.626437799356112 0.284877865171456 no 956 0.265513911517241 1309 3515 A coloring agent.
SGTC_3077 9117319 49.47 µM 0.624761091695703 0.285364666606539 no 957 0.266063935282061 1299 17154678
SGTC_1257 0669-0121 16 µM 0.624536013552747 0.285430044082771 no 958 0.266137813364676 1331 4307855
SGTC_3141 9094609 49.47 µM 0.624164327908288 0.285538021617829 no 959 0.266259835608029 1268 25236309 YDL196W YDL196W
SGTC_1802 st050112 57.9 µM 0.621017356481678 0.286453019324643 no 960 0.267294101688492 1290 4662563
SGTC_2595 hexamethylquercetagetin 100 µM 0.619563383105432 0.286876238782131 no 961 0.26777264019853 1286 386331
SGTC_1163 k060-0048 49.9 µM 0.619362905822364 0.28693461651603 no 962 0.267838656064789 1311 6809982
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.619008384854765 0.287037864583841 no 963 0.267955417580002 1302 2724278 An inhibitor of dopamine biosynthesis.
SGTC_466 geldanamycin 89.2 µM 0.61823622797475 0.287262802724552 no 964 0.268209816201878 1228 5288382 HSP90 inhibitor.
SGTC_1750 st081859 2.357 µM 0.616473311526201 0.287776672877378 no 965 0.268791090477435 1311 5291695
SGTC_1625 st003711 30.1 µM 0.615506255284057 0.288058743126684 no 966 0.269110219790648 1399 24207034 YER133W GLC7
SGTC_2347 9049783 174.81 µM 0.615232450848521 0.288138629897782 no 967 0.269200609990892 1328 6467988 YPL169C MEX67
SGTC_2999 9069765 71.4286 µM 0.613088258551366 0.288764593057253 no 968 0.269908991700199 1338 2097066
SGTC_3031 9088762 49.47 µM 0.610855959295584 0.289416957110473 no 969 0.270647471534689 1286 205253
SGTC_2505 galangin 7.89 µM 0.609934344122473 0.289686490431758 no 970 0.270952650408942 1277 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1508 1080-0625 72.9 µM 0.609574555252626 0.289791745369296 no 971 0.271071835611309 1276 767111
SGTC_558 k064-0027 21.3 µM 0.608408826234007 0.290132898379777 no 972 0.271458179520333 1370 5088526
SGTC_2173 5763948 167 µM 0.607520517032453 0.290392990189678 no 973 0.271752765469249 1331 2867177
SGTC_2711 st079103 59.1 µM 0.607467157105479 0.290408617143515 no 974 0.27177046604414 1327 54693780
SGTC_1633 st005664 67.9 µM 0.605327909129922 0.291035439958688 no 975 0.272480570439616 1329 2063822
SGTC_920 mycophenolic acid 780.421 nM 0.603852768530372 0.291468039963734 no 976 0.272970766412753 1338 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_932 2857-0803 154 µM 0.603633704912754 0.291532308170446 no 977 0.273043599525456 1453 674898
SGTC_1428 4049-0204 61.7 µM 0.603291582059241 0.291632692333014 no 978 0.27315736598834 1400 X1428
SGTC_2473 5854593 8.94 µM 0.603026309274125 0.291710538580369 no 979 0.273245593583326 1330 2872951
SGTC_1109 tnp00067 928.257 nM 0.600823695808356 0.29235728541153 no 980 0.273978709886631 1314 676295
SGTC_1173 0443-0020 122 µM 0.597273563602244 0.293401101226522 no 981 0.275162375817517 1335 5331295
SGTC_1735 st034310 56.75 µM 0.594910496026267 0.294096850058497 no 982 0.275951650450134 1438 871153
SGTC_2603 homopterocarpin 100 µM 0.593511841688188 0.294509009330363 no 983 0.276419330226763 1358 101795 A weak amylase inhibitor.
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.591326332001713 0.295153574426718 no 984 0.277150894803788 1305 6708514
SGTC_358 0075-0058 9.45 µM 0.588896553263209 0.295870942519926 no 985 0.277965335020978 1404 1069125
SGTC_2775 cyproheptadine 69.59 µM 0.588691326469133 0.295931570353739 no 986 0.278034178671156 1360 2913 A selective serotonin reuptake inhibitor.
SGTC_704 1310-0270 142 µM 0.588515050069829 0.295983650253148 no 987 0.278093317506622 1314 5718033
SGTC_640 3381-0960 37.1 µM 0.587971450458258 0.296144280278108 no 988 0.278275727956269 1421 1745025
SGTC_1410 3909-8106 77.9 µM 0.586809211875275 0.296487848059069 no 989 0.278665924654601 1395 1039210
SGTC_2444 5485484 36.41 µM 0.58567664076921 0.296822821490181 no 990 0.279046417239597 1438 6790631
SGTC_422 cantharidin 155 µM 0.584747591216564 0.297097729889999 no 991 0.279358724311919 1306 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_282 k297-0036 65.7 µM 0.584320914916509 0.297224023618619 no 992 0.279502211673906 1382 5061378
SGTC_143 4032-1194 15.74 µM 0.577681834870576 0.299192306123711 no 993 0.281739472692136 1388 1806963
SGTC_961 1252-1571 372 µM 0.573288883169123 0.300497923797883 no 994 0.283224555599078 1459 6813498
SGTC_901 1112-0062 60.1 µM 0.572979256719895 0.300590044064598 no 995 0.283329369531021 1387 1908457
SGTC_2070 5230947 200 µM 0.572248118541216 0.30080762336551 no 996 0.283576946297869 1429 2835538
SGTC_3218 9131285 49.47 µM 0.571394029226894 0.301061881612731 no 997 0.283866287767924 1479 17156417
SGTC_2011 4012611 177 µM 0.571386465327724 0.301064133781491 no 998 0.283868850835672 1360 2049887
SGTC_3041 9091929 49.47 µM 0.570918174671271 0.301203583210537 no 999 0.284027555201683 1412 25236887
SGTC_1717 st033143 58.0435 µM 0.570641101920624 0.301286104719646 no 1000 0.284121475532304 1459 674616
SGTC_2868 9035608 32.47 µM 0.56816020282632 0.302025452497088 no 1001 0.284963095908973 1363 6462614
SGTC_881 0833-0569 170 µM 0.567557800705492 0.30220510087971 no 1002 0.285167634103984 1335 5418700
SGTC_100 0086-0128 49.5915 µM 0.566661070567577 0.302472612565329 no 1003 0.285472237276353 1308 93297
SGTC_101 0490-5701 117.494 µM 0.565744450288392 0.302746167535956 no 1004 0.285783756782474 1337 4661669
SGTC_1900 st060200 72.8 µM 0.565169797925237 0.302917722536043 no 1005 0.285979138632683 1394 688945
SGTC_1873 rapamycin 2 nM 0.56436520005515 0.303157997868481 no 1006 0.286252808604175 1398 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_353 1988-1175 58.3 µM 0.564363709433564 0.303158443088693 no 1007 0.286253315728572 1320 2788357
SGTC_2147 5545932 89.7195 µM 0.564013196035855 0.303263142866757 no 1008 0.286372575741073 1387 797404
SGTC_2477 5967686 25.23 µM 0.562899127377418 0.303596026993432 no 1009 0.286751787226825 1348 776118
SGTC_3023 9089636 49.47 µM 0.561160605548193 0.304115823620814 no 1010 0.287344027904841 1462 17249241
SGTC_852 0418-0143 439 µM 0.560649653317529 0.304268667420878 no 1011 0.287518197634399 1408 5369229
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.560470920690318 0.304322140717467 no 1012 0.287579134511978 1385 17037758
SGTC_1909 st060837 51.5 µM 0.55862281727402 0.304875302151115 no 1013 0.288209582230675 1360 678937
SGTC_976 1348-1067 47.6 µM 0.558465370513368 0.304922448664468 no 1014 0.288263322525387 1417 5310671 YGL099W LSG1
SGTC_3230 9131665 49.47 µM 0.557562006904624 0.305193018206277 no 1015 0.288571753152001 1369 15943720
SGTC_2396 5342950 42.78 µM 0.554922338457149 0.305984244218559 no 1016 0.28947389087002 1423 1886677
SGTC_1063 disulfiram 1.84 µM 0.554598040400013 0.306081513342944 no 1017 0.289584814844518 1383 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_90 0870-0863 4.608 µM 0.55438491232772 0.306145445875158 no 1018 0.289657724737076 1375 1738164
SGTC_3076 9116187 49.47 µM 0.554264605980467 0.306181537062172 no 1019 0.289698884653503 1458 27241210
SGTC_2804 7954240 19.48 µM 0.553954307153387 0.30627463354294 no 1020 0.289805058584791 1453 828705
SGTC_2627 acetyl isogambogic acid 100 µM 0.548122020410397 0.308026769805626 no 1021 0.291804060695786 1346 6857789 A caspase activator and apoptosis inducer.
SGTC_2428 5615643 7.78 µM 0.54567072191356 0.308764500405065 no 1022 0.292646150473367 1437 2253075
SGTC_750 4073-0104 132 µM 0.544848000512501 0.309012275809892 no 1023 0.292929031154845 1307 22330957
SGTC_2876 9059903 25.97 µM 0.543170295255065 0.30951781223045 no 1024 0.293506278372499 1401 6916095
SGTC_2730 imipramine 71.33 µM 0.540696370480294 0.310263928245652 no 1025 0.294358440299737 1451 3696 A tricyclic antidepressant.
SGTC_739 1486-1183 203 µM 0.539815463115468 0.310529791770617 no 1026 0.294662151025602 1454 4346692
SGTC_2493 resveratrol 26.09 µM 0.539358122704602 0.310667859107972 no 1027 0.294819885409253 1383 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1280 0880-0253 10.1 µM 0.539169759962133 0.310724732037855 no 1028 0.294884862077247 1407 6836607
SGTC_1482 3346-2049 8.48 µM 0.535950130950886 0.311697542777068 no 1029 0.295996508245559 1444 3826804
SGTC_1732 st034308 51.822 µM 0.535914576798288 0.311708292818525 no 1030 0.296008794814163 1397 830119
SGTC_710 3448-4187 58 µM 0.535885852678408 0.311716977870012 no 1031 0.296018721276262 1447 3946412
SGTC_923 1900-2434 73.3 µM 0.534834232563689 0.312035018772926 no 1032 0.296382244602708 1386 5910570
SGTC_3152 9099253 49.47 µM 0.534148905043671 0.312242357459231 no 1033 0.296619258242102 1437 25236131
SGTC_449 xestospongin c 11.1929 µM 0.533140710618085 0.312547484253149 no 1034 0.296968089868033 1469 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1201 1889-3372 45.9 µM 0.53299214102065 0.312592459234675 no 1035 0.297019510272976 1413 5392199
SGTC_3316 9136639 10.545 µM 0.532751004793324 0.312665461922906 no 1036 0.29710297694718 1493 4903665
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.53101429702324 0.313191457754005 no 1037 0.297704435912978 1408 2346 DNA damaging agent; causes G2/M arrest.
SGTC_559 1550-0661 158 µM 0.530948673730234 0.313211340512004 no 1038 0.297727173548565 1508 5830875
SGTC_2850 9015429 58.44 µM 0.530830077281366 0.313247274625914 no 1039 0.297768267717891 1423 6457570
SGTC_1192 1488-0095 21.4 µM 0.527039252578918 0.314396807717 no 1040 0.299083165184829 1453 915875
SGTC_1666 st014829 29 µM 0.526907680819724 0.314436738076439 no 1041 0.299128849880229 1423 3858230
SGTC_1138 3761-0006 1.03 µM 0.523262380797527 0.315543902347268 no 1042 0.300395838087476 1466 12061087
SGTC_2138 5575593 77.673 µM 0.522258665222276 0.31584904613745 no 1043 0.300745122359131 1427 762213
SGTC_389 tpck 16.7 µM 0.521081647850046 0.316207036058658 no 1044 0.301154947431368 1443 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2788 5282734 71.43 µM 0.518954681443884 0.316854390034065 no 1045 0.301896172195387 1584 743706
SGTC_2376 9072922 81.32 µM 0.51642055117127 0.317626399094697 no 1046 0.30278035762825 1489 17087968
SGTC_2859 9028643 45.46 µM 0.514538251678022 0.318200345412129 no 1047 0.30343786192227 1431 17151580
SGTC_2025 5147754 141 µM 0.514347523351805 0.31825852623619 no 1048 0.303504520635093 1497 315777 YLR208W SEC13
SGTC_307 1501-1223 22.3 µM 0.514199671384021 0.318303630903821 no 1049 0.303556198748586 1445 2830329
SGTC_2236 dapsone 200 µM 0.513201667757636 0.318608158712485 no 1050 0.30390512973544 1451 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_634 1611-4317 11.2 µM 0.5122053595563 0.318912291441351 no 1051 0.304253646257679 1510 2843522
SGTC_1763 st044482 94.5 µM 0.510596996972137 0.319403517027278 no 1052 0.304816639551533 1511 88505
SGTC_321 4534-3890 65.3 µM 0.505311826525215 0.321019941704263 no 1053 0.306669918789254 1509 699746
SGTC_423 5-fluorouracil 457 µM 0.504565005372065 0.321248625314697 no 1054 0.306932196992236 1408 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2829 7992743 58.44 µM 0.504401121084775 0.321298817287122 no 1055 0.30698976520185 1549 16462845
SGTC_2544 sphondin 68.51 µM 0.503860170206317 0.321464514609879 no 1056 0.307179820691595 1528 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2203 7227154 166.4 µM 0.503484071594797 0.321579737385434 no 1057 0.307311988188402 1470 896304
SGTC_1136 pergolide 1.05886 µM 0.502599080128288 0.321850933913233 no 1058 0.307623088072546 1488 47811 A dopamine receptor agonist.
SGTC_2756 carbadox 75.1 µM 0.502235774599162 0.321962292645332 no 1059 0.307750840468676 1455 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1210 3013-0140 750 nM 0.502170138147938 0.321982412932666 no 1060 0.307773923292014 1601 905973
SGTC_989 1501-0895 10.3 µM 0.500741105317242 0.322420599885037 no 1061 0.308276669600046 1506 2830112
SGTC_1964 st076914 61 µM 0.49978034775351 0.322715337536423 no 1062 0.308614874911989 1480 24208661
SGTC_2442 5158906 48.48 µM 0.499096371592517 0.322925233118526 no 1063 0.30885574679329 1592 1893835
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.498037312291773 0.323250343838355 no 1064 0.309228871733794 1509 66535 A nucleotide analog.
SGTC_78 0336-0123 156.75 µM 0.496534801345478 0.323711817283314 no 1065 0.30975857005362 1443 6765896
SGTC_2431 5490079 200 µM 0.494675323122423 0.324283303257757 no 1066 0.310414661626083 1461 5722345
SGTC_1287 0971-0001 34.6 µM 0.493856880186843 0.324534972196802 no 1067 0.310703629532698 1512 4665869
SGTC_1587 estradiol valerate 56.1 µM 0.493263727962366 0.324717414964958 no 1068 0.310913126997312 1516 13791 A steroid.
SGTC_3346 9158254 43.5805 µM 0.490695929017086 0.32550770762864 no 1069 0.311820763119823 1487 17639500
SGTC_301 4119-0100 24.5 µM 0.490072611548624 0.325699664890667 no 1070 0.3120412590103 1512 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2949 9072542 2.23 µM 0.48978821326851 0.325787263734376 no 1071 0.312141886070566 1468 16457352
SGTC_2895 9054447 58.44 µM 0.489147302862264 0.325984708803463 no 1072 0.312368707212518 1509 2697450
SGTC_3196 9111891 49.47 µM 0.488133359718743 0.326297173614591 no 1073 0.31272769158563 1465 18891510
SGTC_3040 9091894 49.47 µM 0.488111818327045 0.326303813305539 no 1074 0.312735320197631 1478 25236966
SGTC_2257 7960413 200 µM 0.484278167467407 0.32748633228546 no 1075 0.314094234114058 1585 2974689 YIL048W NEO1
SGTC_1500 4488-1866 171 µM 0.484215030161289 0.327505822007553 no 1076 0.314116635568774 1596 2900003
SGTC_2767 sibutramine 71.45 µM 0.484151874891297 0.327525317745174 no 1077 0.31413904408233 1614 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_3337 9144342 33.5465 µM 0.484070256599224 0.327550513628347 no 1078 0.314168004590335 1569 17682949
SGTC_387 norethindrone acetate 66.7 µM 0.482738697327449 0.327961681995861 no 1079 0.314640641464289 1492 541197
SGTC_839 0122-0028 230 µM 0.482170384433911 0.328137233248986 no 1080 0.314842456658887 1512 759448
SGTC_3317 9138495 8.753 µM 0.478919328595667 0.329142209815331 no 1081 0.315998009945646 1498 17020139
SGTC_2459 5811157 9.22 µM 0.478431193565355 0.329293210544261 no 1082 0.316171668063314 1481 2870684 YBR192W RIM2
SGTC_2940 9060638 45.86 µM 0.477792423246665 0.329490851177144 no 1083 0.316398977206242 1535 4027022
SGTC_2995 9067767 71.4286 µM 0.477388543682633 0.329615839324131 no 1084 0.316542735281138 1527 11673567
SGTC_740 k014-0057 261 µM 0.475700537619403 0.330138430513914 no 1085 0.317143868933153 1625 4012779
SGTC_841 0251-0215 91.2 µM 0.475434947350517 0.330220685039292 no 1086 0.317238495086886 1556 3888614
SGTC_1167 k781-0610 148 µM 0.4753007839545 0.330262239178671 no 1087 0.317286300199525 1526 4525169
SGTC_1232 0279-0259 161 µM 0.475076677395381 0.330331655889025 no 1088 0.317366160666528 1502 1560000
SGTC_1853 st056710 91.2 µM 0.472503814069973 0.331129014727552 no 1089 0.318283609991274 1675 269167
SGTC_909 3448-9333 149 µM 0.471336294577161 0.331491094974034 no 1090 0.318700300532702 1484 3344074
SGTC_2262 9014885 67.46 µM 0.46701270030525 0.33283333146588 no 1091 0.320245395797553 1530 6457424
SGTC_1230 0170-0365 3.77 µM 0.466211124427374 0.333082412593576 no 1092 0.32053219368561 1594 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2805 7950783 58.44 µM 0.466035933080229 0.333136861241963 no 1093 0.320594890126544 1572 1178958 YDL195W SEC31
SGTC_3226 9131256 49.47 µM 0.465742122839656 0.333228183981254 no 1094 0.320700048684773 1454 17178073
SGTC_1142 3253-1408 9.78 µM 0.464343056378431 0.333663180439952 no 1095 0.321200990309896 1535 256655
SGTC_2525 harmine 47.85 µM 0.462882010069439 0.334117686405082 no 1096 0.321724471560662 1610 5280953 A monoamine oxidase inhibitor
SGTC_2295 7971645 200 µM 0.461774675441155 0.33446232102056 no 1097 0.32212145670068 1596 2978226 YKL099C UTP11
SGTC_1356 1502-0781 85.8 µM 0.461745257100757 0.334471478764501 no 1098 0.32213200609699 1531 567702
SGTC_52 0329-0193 875 nM 0.461459077852889 0.334560569699308 no 1099 0.322234637251711 1611 3739292
SGTC_2235 salicylic acid 500 µM 0.461024396378527 0.334695908928675 no 1100 0.322390551008081 1556 338 A COX inhibitor and kinase inhibitor.
SGTC_180 1486-1293 102.781 µM 0.459719974951461 0.335102172873476 no 1101 0.322858614993147 1698 4140536
SGTC_1908 st060353 56.5 µM 0.459469170637058 0.335180308376034 no 1102 0.322948643007297 1713 4227716
SGTC_3288 9119690 36.221 µM 0.459406170907324 0.33519993641426 no 1103 0.322971258844373 1485 17595618 YKL019W RAM2
SGTC_1390 3413-2614 145 µM 0.457450674109641 0.335809409624397 no 1104 0.32367357424254 1548 3421432
SGTC_2560 caryophyllene 100 µM 0.457336857970697 0.335844896226877 no 1105 0.323714470610979 1548 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2636 apigenin dimethyl ether 100 µM 0.45670668542071 0.336041403477119 no 1106 0.32394094246549 1552 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1165 k072-0275 30.3 µM 0.455803652108832 0.33632307525795 no 1107 0.324265588834102 1542 6153523 YGL055W OLE1
SGTC_2081 5214970 32.255 µM 0.455288472972352 0.336483809762165 no 1108 0.324450858983787 1626 2063512
SGTC_108 0509-0257 621.132 µM 0.455149993472207 0.336527020090947 no 1109 0.324500666778509 1523 536624
SGTC_2266 7929956 200 µM 0.455010783275134 0.336570460598062 no 1110 0.324550740551922 1524 2967153
SGTC_2717 st081029 62.2815 µM 0.453344162038004 0.33709069856275 no 1111 0.325150468679159 1573 5292846
SGTC_2120 5538279 151.968 µM 0.452924181531216 0.337221845231788 no 1112 0.325301668831294 1579 2058197
SGTC_683 panaxydol 45 µM 0.450975108236701 0.337830738085749 no 1113 0.326003744652143 1629 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_205 1486-1330 71.903 µM 0.44963114414899 0.338250841557019 no 1114 0.326488213801623 1581 4118834
SGTC_2118 5526350 200 µM 0.448764076359584 0.338521981181939 no 1115 0.32680092790252 1591 743594
SGTC_803 4488-1585 147 µM 0.447284965103005 0.338984705295731 no 1116 0.327334660570806 1622 747204
SGTC_474 dl-dihydrosphingosine 5 µM 0.447118070438346 0.339036931774809 no 1117 0.327394906182213 1605 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_223 busulfan 5 mM 0.444438625995446 0.339875835352983 no 1118 0.328362746210725 1600 2478 A DNA alkylator.
SGTC_2462 5162487 171.77 µM 0.444098968723416 0.339982234942561 no 1119 0.32848551602416 1582 2259986
SGTC_1070 indatraline 8.81 µM 0.443295806524991 0.340233880804861 no 1120 0.328775894291577 1533 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_758 0868-0029 16 µM 0.442199617545459 0.340577452328934 no 1121 0.329172381404123 1690 762687
SGTC_1373 2887-0003 58.5 µM 0.441450087468633 0.3408124489561 no 1122 0.329443594079675 1549 776948
SGTC_1062 mesoridazine 14.2 µM 0.441116445894029 0.340917073903096 no 1123 0.32956434903012 1573 4078 A neuroleptic.
SGTC_496 calpeptin 138 µM 0.440275056287945 0.341180975268626 no 1124 0.3298689522126 1515 73364 A calpain inhibitor.
SGTC_1901 st060216 58.6 µM 0.439818007788769 0.341324360843807 no 1125 0.330034462027067 1543 688792
SGTC_1540 guanosine 70.6 µM 0.438940106374462 0.3415998409418 no 1126 0.330352467554955 1595 6802 Guanosine is a purine nucleoside
SGTC_3194 9111903 49.47 µM 0.436882016143447 0.342245987701569 no 1127 0.331098457435253 1630 17087251
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.436504733643537 0.342364487430476 no 1128 0.331235282765904 1513 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2433 5607874 27.82 µM 0.435708165425095 0.342614730542644 no 1129 0.331524240318694 1521 2252428
SGTC_1648 st011736 69.8 µM 0.435551563914141 0.3426639352743 no 1130 0.331581059797773 1637 2855514
SGTC_2319 6033012 152.6 µM 0.434965665064394 0.342848050374035 no 1131 0.331793674918822 1496 847246
SGTC_2708 st078559 56 µM 0.434888357200704 0.342872346681963 no 1132 0.331821732991708 1541 17250902
SGTC_2060 5238662 140 µM 0.434801691723199 0.342899584672431 no 1133 0.331853188433246 1563 790130
SGTC_1321 1326-2144 215 µM 0.434453884679949 0.343008904749667 no 1134 0.331979437750234 1652 3513030
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.431243837924861 0.344018481725266 no 1135 0.333145540903911 1565 3256 An antibiotic and ribosome inhibitor.
SGTC_3291 9121177 71.43 µM 0.430992006694906 0.344097731175347 no 1136 0.333237091270369 1549 17015612
SGTC_3310 9130229 44.1445 µM 0.429696330971908 0.344505579055854 no 1137 0.333708276360661 1636 7761258
SGTC_2420 aureobasidin a 50 nM 0.429474009950315 0.344575578612451 no 1138 0.333789151957806 1707 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_3242 9133940 49.47 µM 0.42936407284197 0.344610195159586 no 1139 0.333829147562675 1607 17248444
SGTC_1710 st031758 61.5 µM 0.427278486799768 0.345267142171952 no 1140 0.334588250150108 1661 5394341
SGTC_2185 6113692 200 µM 0.426656419146066 0.345463180140366 no 1141 0.334814798798601 1599 874150
SGTC_772 k072-0172 35.3 µM 0.426598605849928 0.345481401488747 no 1142 0.33483585667647 1484 5861980
SGTC_862 0452-0056 10.2 µM 0.424132070560134 0.346259126606972 no 1143 0.335734748908505 1574 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_557 1315-0110 16.2 µM 0.423842008786863 0.346350628900064 no 1144 0.335840519537336 1531 6833801
SGTC_2192 5915882 198.485 µM 0.422471163814564 0.346783194118552 no 1145 0.336340572116415 1579 2876149
SGTC_1552 6-methylflavone 10.6 µM 0.422439509593987 0.346793184856567 no 1146 0.33635212226963 1661 689013
SGTC_1797 st048695 56.8 µM 0.421912544085106 0.346959521902896 no 1147 0.336544426808777 1680 592262 YIL048W NEO1
SGTC_1864 st057645 30.4 µM 0.420772604002018 0.347319445699051 no 1148 0.336960569255321 1643 688666
SGTC_2015 5119600 184 µM 0.419891798598 0.347597644858812 no 1149 0.337282249679491 1705 2828786
SGTC_2186 6124449 200 µM 0.418793790530531 0.347944561633967 no 1150 0.337683421656286 1641 3834182 YLR033W RSC58
SGTC_1739 st037196 92.5 µM 0.418399969464926 0.348069020840684 no 1151 0.337827354444979 1746 612214
SGTC_858 0438-0351 2.77 µM 0.417760218783909 0.348271236028683 no 1152 0.33806121955815 1563 2799119
SGTC_1850 st056238 17 µM 0.41751597545149 0.34834844890943 no 1153 0.338150520824357 1560 5393177
SGTC_2453 5731132 22.18 µM 0.417203168578075 0.348447346027672 no 1154 0.338264903878462 1733 1362040
SGTC_2782 7736369 71.43 µM 0.416651916484271 0.348621655134653 no 1155 0.338466514736389 1603 2950836 YOL077C BRX1
SGTC_160 3453-0671 289.699 µM 0.415677224501748 0.348929936593949 no 1156 0.338823104665967 1529 5322268
SGTC_109 0132-0036 33.701 µM 0.413934911152006 0.349481254375804 no 1157 0.339460887822581 1584 67274 A color developer.
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.413891444827758 0.349495012430227 no 1158 0.339476804793451 1590 5282362
SGTC_1491 4138-0063 26.5 µM 0.412937485664273 0.349797011393978 no 1159 0.339826207987884 1671 23883227
SGTC_459 nigericin 15.3 µM 0.412747415691597 0.349857194027011 no 1160 0.339895840689138 1629 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2991 9074669 71.4286 µM 0.407170380537861 0.351624747072303 no 1161 0.3419414271786 1700 17333109
SGTC_234 nsc-17383 10.7 µM 0.406659120388477 0.351786944209535 no 1162 0.342129184485831 1696 408974
SGTC_1746 st038117 42 µM 0.400911620206957 0.353612187277946 no 1163 0.344242597137488 1625 2898218
SGTC_1297 1068-0111 14.1 µM 0.398833993683467 0.354272814278188 no 1164 0.345007763755555 1572 767057
SGTC_1091 telmisartan 47.6 µM 0.396391220528809 0.355050108818323 no 1165 0.345908220903492 1701 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1024 4507-0395 26 µM 0.395798858441056 0.355238690492834 no 1166 0.346126709516096 1656 4201836
SGTC_2325 6158266 200 µM 0.394643744454489 0.355606529228438 no 1167 0.346552912529091 1611 3623240
SGTC_2112 5488546 200 µM 0.391698004982422 0.356545189542895 no 1168 0.347640682141196 1612 600757
SGTC_1028 k015-0029 4.8 µM 0.389668884420432 0.357192275293958 no 1169 0.348390703963053 1599 4588309
SGTC_1841 st054148 70 µM 0.389016052817202 0.35740055050084 no 1170 0.348632135728174 1591 675442
SGTC_3099 9120367 49.47 µM 0.388437796349901 0.35758506921898 no 1171 0.348846039153434 1644 24824940
SGTC_1158 4092-0494 91.8 µM 0.387237768952744 0.357968098095398 no 1172 0.349290095743526 1729 1148199
SGTC_2806 7952793 58.44 µM 0.38714006503524 0.357999289869862 no 1173 0.34932625906887 1667 2972490
SGTC_1887 st057648 70.8 µM 0.38690221399567 0.358075227286994 no 1174 0.349414301016379 1766 688672
SGTC_2146 5545642 200 µM 0.386482017977333 0.35820939472212 no 1175 0.349569858817973 1645 825326
SGTC_2607 solasodine 47.35 µM 0.385040476568934 0.358669807922923 no 1176 0.350103713550627 1620 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_731 3966-0296 387 µM 0.384292101849149 0.358908912021488 no 1177 0.350380980618238 1655 660956
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.383554931237993 0.359144490491114 no 1178 0.350654174620476 1686 279621
SGTC_1992 st073643 23.3 µM 0.38243752921155 0.359501682072625 no 1179 0.351068428912323 1654 3161292
SGTC_1298 1079-1278 263 µM 0.382238743629133 0.359565239253373 no 1180 0.35114214322695 1658 2840950
SGTC_3097 9117246 49.47 µM 0.380785820574296 0.360029896304315 no 1181 0.351681090793498 1634 16423892
SGTC_3347 9188721 44.724 µM 0.380717732598463 0.360051676493673 no 1182 0.351706354684425 1688 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1084 voriconazole 435 nM 0.373553113054617 0.362346043533203 no 1183 0.354368411410248 1769 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1740 st038286 13.222 µM 0.371805298282707 0.362906511007802 no 1184 0.355018909295438 1698 716786
SGTC_569 4130-2812 160 µM 0.370259555639913 0.363402425361978 no 1185 0.355594552826141 1743 743552
SGTC_2677 mitomycin C 100 µM 0.368304051901198 0.364030129771882 no 1186 0.356323265786409 1682 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2520 obtusaquinone 4.71 µM 0.368166292591029 0.364074363425785 no 1187 0.356374621229381 1760 5967872
SGTC_615 k087-0205 167 µM 0.366400513915144 0.364641504115901 no 1188 0.357033118155698 1606 9642773
SGTC_2685 mycophenolic acid 18.85 µM 0.365524424959631 0.364923000366426 no 1189 0.357359988897502 1738 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2606 farnesol 9.78 µM 0.364829348840577 0.365146387175968 no 1190 0.357619397836967 1764 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1609 st001574 46.4 µM 0.363990962962158 0.365415892437849 no 1191 0.357932378850941 1645 3960012
SGTC_707 0865-0008 204 µM 0.36387060649236 0.365454587362587 no 1192 0.357977317426926 1740 723043
SGTC_1834 st055981 52.8 µM 0.362988318434247 0.365738287109188 no 1193 0.358306805300492 1791 471719 YDL150W RPC53
SGTC_2140 5586273 200 µM 0.362675065674303 0.365839031217639 no 1194 0.358423814019011 1671 854421
SGTC_1379 2144-0755 36.5 µM 0.361695633063052 0.366154082725668 no 1195 0.358789745371501 1816 5392327
SGTC_56 0957-0365 83.25 µM 0.360529797127843 0.366529211742034 no 1196 0.359225488916474 1697 6752360
SGTC_2873 9040596 71.43 µM 0.360270533871403 0.366612651780953 no 1197 0.35932241622533 1633 6463863
SGTC_3227 9130768 49.47 µM 0.358131501692208 0.367301307847594 no 1198 0.360122452738563 1727 17720899
SGTC_1689 st020265 53.493 µM 0.357012691300976 0.367661676306818 no 1199 0.360541152359768 1783 5758320 YPR016C TIF6
SGTC_411 enrofloxacin 100 µM 0.356123449745131 0.367948183867338 no 1200 0.36087405829009 1852 71188 A bacterial gyrase inhibitor.
SGTC_889 0919-1524 82.7 µM 0.353712380756016 0.368725383144684 no 1201 0.361777221594774 1671 3905452
SGTC_2330 7979373 200 µM 0.353660350301338 0.368742160904475 no 1202 0.361796720214078 1572 1863007
SGTC_1494 4358-1428 177 µM 0.352879361212241 0.368994028981376 no 1203 0.362089442060463 1837 1564571
SGTC_276 colchicine 750 µM 0.352322439164992 0.36917367007062 no 1204 0.362298230823383 1716 2833 A microtubule depolymerizer.
SGTC_1151 3909-8316 15.3 µM 0.351186834650937 0.369540059804856 no 1205 0.36272409316702 1686 800431
SGTC_99 0109-0120 622.8 µM 0.35062248294375 0.369722185491548 no 1206 0.362935793566855 1790 759414
SGTC_1481 3346-2004 36 µM 0.349784055352421 0.369992813985746 no 1207 0.363250383030493 1709 2770522
SGTC_2851 9015922 71.43 µM 0.349060840528003 0.370226305719486 no 1208 0.363521817224686 1786 2996893
SGTC_641 4092-0595 30 µM 0.347574234446799 0.370706410371824 no 1209 0.364079979555431 1763 786260
SGTC_222 nsc-310342 10.666 µM 0.343888969556925 0.371897446643795 no 1210 0.365464893778024 1824 432556
SGTC_1334 1486-0610 236 µM 0.336535923778881 0.374277525055307 no 1211 0.368233383207876 1756 3742339
SGTC_226 1,3-diallylurea 8.28947 mM 0.335594117252171 0.374582723334338 no 1212 0.368588480371661 1752 74537 YKL182W FAS1
SGTC_199 4063-0024 41.6 µM 0.334468318745713 0.374947648465496 no 1213 0.369013096828842 1814 306215
SGTC_2269 7935389 174.42 µM 0.333415097426109 0.375289149260131 no 1214 0.369410484205044 1662 97605
SGTC_981 1488-1094 54.9 µM 0.331371243634828 0.375952135515013 no 1215 0.370182041644077 1702 3449522
SGTC_1737 st035557 69.7 µM 0.328474177669892 0.376892514386494 no 1216 0.371276582697662 1672 5716916
SGTC_2849 9019321 12.99 µM 0.328471862648442 0.376893266128417 no 1217 0.371277457754145 1760 16489627
SGTC_1164 k060-0068 93.7 µM 0.324536687852439 0.378171782431458 no 1218 0.372765875546139 1751 5963676
SGTC_1424 4048-1941 275 µM 0.324276031743796 0.378256515446245 no 1219 0.372864532001591 1859 X1424
SGTC_335 4077-0256 27.6 µM 0.323511530467 0.378505070131865 no 1220 0.373153938291929 1828 3121989
SGTC_1456 k015-0012 13 µM 0.323030941355437 0.378661345024543 no 1221 0.373335904678221 1915 2989616
SGTC_1214 0358-0031 63.7 µM 0.318998370168778 0.379973410209728 no 1222 0.37486387434435 1906 4301366
SGTC_2931 9014674 55.67 µM 0.318235062464766 0.380221921365614 no 1223 0.375153319076491 1690 2996810
SGTC_2434 5670830 169.91 µM 0.315343415369224 0.381163806687942 no 1224 0.376250462277409 1755 1549830
SGTC_1118 chelidonine 707.474 nM 0.314850747545299 0.381324351909403 no 1225 0.376437489378902 1901 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2670 beta-carotene 100 µM 0.313211967149933 0.381858526626611 no 1226 0.377059813531119 1813 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_3202 9113761 49.47 µM 0.312105218792174 0.382219408243009 no 1227 0.377480280241967 1906 4798415
SGTC_945 3381-0768 11.3 µM 0.311728634735535 0.382342225779831 no 1228 0.377623382098075 1860 1126236 YIL048W NEO1
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.311366501222676 0.382460341642391 no 1229 0.377761008596427 1876 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_775 4577-0580 57.3 µM 0.310364936199926 0.382787075636297 no 1230 0.378141727668632 1806 2006902
SGTC_92 0063-0024 660.874 µM 0.310025046431043 0.382897974621121 no 1231 0.378270954901778 1876 3594437
SGTC_1791 st048313 56.1 µM 0.309460221194605 0.383082286614268 no 1232 0.378485733467913 1884 1204976
SGTC_334 1502-1024 68.5 µM 0.307965541291724 0.383570153469339 no 1233 0.379054276447559 1772 3296216
SGTC_291 SEC14.278 35.5 µM 0.306817579154487 0.383944976282545 no 1234 0.379491113490569 1857 1068044
SGTC_1433 4060-0023 7.6 µM 0.305934862588621 0.384233267245067 no 1235 0.379827120628014 1824 3840627
SGTC_337 1315-0038 354 µM 0.305804182633617 0.384275952133841 no 1236 0.379876871830114 1762 1626437
SGTC_2532 xanthone 78.9 µM 0.305244943505846 0.384458636088939 no 1237 0.380089802364977 1836 7020 An insecticide.
SGTC_3090 9117696 49.47 µM 0.30428750302815 0.384771458123918 no 1238 0.380454432591321 1890 7923821
SGTC_1786 berberine 21.6 µM 0.30342208090213 0.385054279810553 no 1239 0.380784110111805 1720 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2289 7946404 165.07 µM 0.302888720543147 0.385228613517352 no 1240 0.380987333772409 1725 1246120 YPR165W RHO1
SGTC_1243 0416-0003 5.65 µM 0.301837115935975 0.385572408019784 no 1241 0.38138811761326 1756 2141977
SGTC_1044 1222-0021 1.78 µM 0.301154036656902 0.385795771039822 no 1242 0.381648518570267 1829 4306703
SGTC_12 0849-0099 9.267 µM 0.2981066277394 0.386792716724302 no 1243 0.382810891611784 1879 6071388
SGTC_1111 tnp00062 510.699 nM 0.297654516943797 0.386940686504754 no 1244 0.382983430442054 1894 676306
SGTC_1251 0490-5699 265 µM 0.2971623050705 0.387101799512961 no 1245 0.383171299428014 1917 3883818
SGTC_3078 9116413 49.47 µM 0.295245249672208 0.387729483905229 no 1246 0.38390326876908 1761 17177322
SGTC_611 3453-1652 23.7 µM 0.292885214794775 0.38850261207341 no 1247 0.384804945217312 1895 1560575
SGTC_2352 9027995 87.8 µM 0.2917053472657 0.388889292938897 no 1248 0.38525596021613 1845 2997347
SGTC_2496 diffractaic acid 79.83 µM 0.290756690825581 0.389200278298805 no 1249 0.385618705318129 1918 94870 An apoptosis inducer which activates caspases.
SGTC_264 promethazine 12.5 mM 0.289436638584261 0.389633131456944 no 1250 0.386123630343892 1927 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1865 st057639 52.2 µM 0.288021963463306 0.390097164042482 no 1251 0.386664963158027 1833 688818
SGTC_1157 4092-0394 27.6 µM 0.287913398217222 0.390132781392877 no 1252 0.386706515343244 1882 3659885
SGTC_1590 st077108 57.8 µM 0.287896304282649 0.390138389539171 no 1253 0.386713057981991 1924 5489485
SGTC_885 0865-0106 16.8 µM 0.287750707757462 0.390186157503279 no 1254 0.386768785805727 1731 2793380
SGTC_3229 9132204 49.47 µM 0.287579597072751 0.390242298387156 no 1255 0.386834282290384 1851 17682924
SGTC_383 2324-0395 7.37 µM 0.286900741850396 0.39046505122009 no 1256 0.387094161221929 1867 3146421
SGTC_2601 securinine 100 µM 0.286883579943795 0.390470683024565 no 1257 0.38710073178877 1747 442872 A GABA receptor antagonist.
SGTC_2877 9040724 71.43 µM 0.286511452137557 0.390592805120519 no 1258 0.387243211710419 1939 6463895
SGTC_990 3985-0011 41.3 µM 0.28534050795058 0.390977147112482 no 1259 0.387691640673451 1800 5399565 YGL099W LSG1
SGTC_342 k048-0088 23.3 µM 0.283612601452023 0.391544496716499 no 1260 0.388353639468416 1760 6820570
SGTC_138 0850-0259 40.9225 µM 0.282986278401571 0.391750203861424 no 1261 0.388593677759897 1852 6813004
SGTC_541 4513-1321 94 µM 0.282420658594028 0.39193599987791 no 1262 0.388810488100158 1759 747515
SGTC_3169 9102970 49.47 µM 0.281027055026651 0.392393878874342 no 1263 0.389344824387577 1851 17027839
SGTC_2384 9036245 200 µM 0.28066430516313 0.392513087552922 no 1264 0.389483944521023 1894 6462766
SGTC_53 0973-0023 39.979 µM 0.277997125598285 0.393389898483551 no 1265 0.390507282630918 1986 674768
SGTC_317 4495-0002 170 µM 0.27675353457546 0.393798902871704 no 1266 0.390984681015398 1784 15991618
SGTC_3135 9127742 49.47 µM 0.2756829434592 0.394151103241206 no 1267 0.391395798648272 1776 3643468
SGTC_3161 9100388 49.47 µM 0.27441091476826 0.394569684558957 no 1268 0.391884428032807 1861 25236368
SGTC_762 1165-0429 115 µM 0.274228766802823 0.394629633227527 no 1269 0.391954411227099 1936 5967793
SGTC_580 1123-0028 41 µM 0.274021951104853 0.394697703582937 no 1270 0.392033876265599 1864 1677248 YPR107C YTH1
SGTC_1796 st049173 110.4 µM 0.27401613500476 0.394699617913516 no 1271 0.392036111057688 1921 94134
SGTC_400 oxethazaine 37.5 µM 0.273342896813474 0.39492122694656 no 1272 0.392294821745606 1811 4621 A local anesthetic.
SGTC_795 0685-0265 78 µM 0.273272146686547 0.394944517659058 no 1273 0.392322012236057 1800 302754
SGTC_2488 5268135 45.7 µM 0.269946574291966 0.396039707482643 no 1274 0.393600677825208 1902 1270356 YLR208W SEC13
SGTC_2838 9002687 71.43 µM 0.269311355638204 0.39624899370573 no 1275 0.393845047182006 1746 6457060
SGTC_2495 cafestol 54.53 µM 0.26844033064605 0.396536019919696 no 1276 0.394180199462785 1882 16667697 An anti-infammatory.
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.265185181657721 0.397609174450319 no 1277 0.395433404851512 1803 5355888
SGTC_2406 ethylparaben 405.7 µM 0.264858272785953 0.39771699244535 no 1278 0.395559322065246 1600 8434 A possible steroid mimic.
SGTC_1611 st001856 99.4 µM 0.260426668196698 0.39917935002625 no 1279 0.397267337102827 1796 647478
SGTC_2216 7189485 200 µM 0.260073848020468 0.399295836080893 no 1280 0.397403405118355 1932 731273
SGTC_1374 2889-5571 141 µM 0.260070250465084 0.399297023885223 no 1281 0.397404792609641 1818 2853281
SGTC_3125 9127534 49.47 µM 0.257810634955476 0.400043264556684 no 1282 0.398276528187202 1960 1639235
SGTC_1691 st019933 84.6 µM 0.256394479267126 0.400511137951575 no 1283 0.39882312516475 2000 6176082
SGTC_1436 4092-1007 8.32 µM 0.253790925103091 0.401371679421465 no 1284 0.399828542341981 1870 2881121
SGTC_2097 5376186 200 µM 0.252930745823346 0.401656096138089 no 1285 0.400160865018393 1956 742755
SGTC_2987 9018338 71.43 µM 0.252341831789511 0.401850849549422 no 1286 0.400388428474243 1855 5055682
SGTC_1664 st014217 9.02 µM 0.25173770248545 0.402050659967006 no 1287 0.400621906434735 1972 3982782
SGTC_448 monastrol 171 µM 0.248779432352745 0.403029450301421 no 1288 0.401765700807347 1935 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2370 9071495 200 µM 0.248647553835538 0.403073098588963 no 1289 0.401816710386414 1826 21791103
SGTC_2000 st075254 36.4 µM 0.248623300139992 0.403081126049704 no 1290 0.401826091708294 1852 17234175
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.24834958997558 0.403171721161403 no 1291 0.401931966634882 1927 688801
SGTC_2863 9028737 58.44 µM 0.248057983732611 0.403268245400347 no 1292 0.402044771933647 2007 6460917
SGTC_2661 dactinomycin 12.96 µM 0.247655461619276 0.403401493452498 no 1293 0.402200497461111 1894 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_3074 9116018 49.47 µM 0.247032015247417 0.403607896829198 no 1294 0.40244172357827 1879 17027303
SGTC_681 1642-0006 26.6 µM 0.246614616925071 0.403746099221785 no 1295 0.402603245611276 1923 4446530
SGTC_62 0180-0423 3.232 µM 0.244744688405296 0.404365387942573 no 1296 0.403327061866051 1926 30102 YGL099W LSG1
SGTC_3335 9143315 29.6265 µM 0.24311489771713 0.404905342640597 no 1297 0.403958195337661 1846 4899691
SGTC_1237 0330-0133 46.1 µM 0.241095033350102 0.405574781168164 no 1298 0.404740731036352 1862 X1237 YHR072W ERG7
SGTC_3248 9135562 49.47 µM 0.236211549186863 0.407194439826463 no 1299 0.406634259055851 1870 17650701
SGTC_1920 st075728 45.7 µM 0.235269322045545 0.407507122954435 no 1300 0.406999852178234 2026 3400306
SGTC_1017 4239-0030 168 µM 0.23427597723652 0.40783683357427 no 1301 0.407385367205282 1812 1149593
SGTC_549 1661-1316 519 µM 0.2341384961116 0.407882471403487 no 1302 0.407438730416795 1995 2857282
SGTC_3212 9128307 49.47 µM 0.233681880329481 0.40803405719978 no 1303 0.407615977864949 1696 27243542
SGTC_2726 cimetidine 79.27 µM 0.233414092521595 0.408122962915505 no 1304 0.407719935560025 1990 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2033 5192550 145 µM 0.232980767859361 0.408266836986282 no 1305 0.407888169949589 1850 182073
SGTC_2220 6782180 200 µM 0.232304727021046 0.408491323278731 no 1306 0.408150670613376 1979 833803
SGTC_137 0438-0332 85.389 µM 0.231940606858966 0.408612245560237 no 1307 0.408292072334312 1961 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.228660061567584 0.409702087403425 no 1308 0.409566569315421 1889 689007
SGTC_326 k292-0812 17.5 µM 0.228383078808537 0.409794136924498 no 1309 0.409674221516722 2003 3579357
SGTC_3234 9132280 49.47 µM 0.227890866824458 0.409957725715288 no 1310 0.409865541571225 1908 17612295
SGTC_2274 7947094 46.08 µM 0.225708129087531 0.41068335656799 no 1311 0.410714217566831 2040 2971028
SGTC_3262 9137218 49.47 µM 0.225607573970935 0.410716792568307 no 1312 0.410753324772352 1938 17650664
SGTC_2340 7987427 183.45 µM 0.224398685902779 0.411118815691212 no 1313 0.411223546558538 1937 2239331
SGTC_2725 haloperidol 53.21 µM 0.223405722933977 0.411449101460962 no 1314 0.411609875312162 1989 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_682 0kpi-0099 17 µM 0.223231971922241 0.411506902105923 no 1315 0.411677484853637 1866 1714895 YML126C ERG13
SGTC_2728 chlorpromazine 9.18 µM 0.223171350196978 0.411527069202055 no 1316 0.411701074438787 1963 2726 A thorazine and dopamine antagonist.
SGTC_3117 9124945 49.47 µM 0.221177652286859 0.412190444830708 no 1317 0.412477054631076 1814 17592065
SGTC_1620 st003704 16.5 µM 0.219345165817358 0.412800400972949 no 1318 0.413190590594306 2021 2834414
SGTC_1766 st045414 44.774 µM 0.21880491134971 0.412980268775147 no 1319 0.4134010104366 1929 253960
SGTC_2623 humulene 100 µM 0.218643875442779 0.413033886258796 no 1320 0.413463735973398 1879 6187145 An anti-inflammatory.
SGTC_98 0074-0023 107.663 µM 0.217352347328675 0.413463963781537 no 1321 0.413966882379309 1864 3563821
SGTC_2935 9038016 29.96 µM 0.217209418616881 0.413511565285712 no 1322 0.414022572455291 2041 6463195
SGTC_1975 st070967 30.8 µM 0.216903579679593 0.413613427280279 no 1323 0.414141743917601 2060 261391
SGTC_1600 coumarin 106 71.1 µM 0.216808896353227 0.413644963464315 no 1324 0.414178639287611 1950 100336 A hepatotoxic, DNA x-linker.
SGTC_2276 7947513 42.08 µM 0.216158574655031 0.413861581211804 no 1325 0.41443207140531 1760 2105100
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.212173183411168 0.415189658182577 no 1326 0.415985963496326 1918 390807
SGTC_561 1550-0330 72.9 µM 0.2108770792043 0.415621776820963 no 1327 0.416491595045095 1891 6812934
SGTC_250 brefeldin a 552.239 µM 0.210222834975679 0.415839939375946 no 1328 0.416746879013599 1942 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1782 st039423 80.636 µM 0.210149418639205 0.415864422213834 no 1329 0.416775528022272 1864 2068169
SGTC_3138 9097216 49.47 µM 0.210050998365923 0.415897243862562 no 1330 0.416813934926065 2107 25237486
SGTC_2331 7980721 200 µM 0.209699257796308 0.416014548730522 no 1331 0.416951202424156 2023 2981221
SGTC_1171 0368-0077 21.4 µM 0.208936828822286 0.416268843141495 no 1332 0.417248776675242 1911 3239779
SGTC_2776 terbinafine 19.92 µM 0.206272564495723 0.417157734973667 no 1333 0.418289004028518 2031 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_142 0335-0849 62.6745 µM 0.205859385680096 0.417295623943271 no 1334 0.418450375717887 1959 3889043 YPR107C YTH1
SGTC_299 1273-0059 1.44 µM 0.204918354424415 0.417609709519278 no 1335 0.418817957375629 2043 2848077
SGTC_2652 actinonin 100 µM 0.204412041747126 0.417778721960404 no 1336 0.419015760448172 1982 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_156 3474-0145 5.642 µM 0.202782739323598 0.418322702991802 no 1337 0.419652424836121 2079 2265471
SGTC_1513 0337-0559 19 µM 0.201784372229208 0.418656108666142 no 1338 0.42004264970008 1886 775073
SGTC_726 3448-4391 34.2 µM 0.201178112221411 0.418858598327539 no 1339 0.420279652761028 2010 1356692
SGTC_260 nsc-65238 3.989 µM 0.199657751393514 0.419366490324996 no 1340 0.420874128955922 2006 3246252
SGTC_2052 5265182 7.135 µM 0.198759708475814 0.419666553878479 no 1341 0.421225357535431 2028 1239884
SGTC_1435 4092-0789 56.7 µM 0.198388483047304 0.419790605283081 no 1342 0.421370563782828 2045 2248285
SGTC_1156 4092-0367 4.88 µM 0.197775507853615 0.419995458998565 no 1343 0.42161035477581 1948 1357585
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.197499099610694 0.42008784055841 no 1344 0.421718492985217 2013 5377381
SGTC_2843 9000894 45.46 µM 0.196298494264915 0.420489159635018 no 1345 0.422188269933691 2003 2242070
SGTC_355 1311-2252 105 µM 0.195418600954295 0.420783328756843 no 1346 0.422532627933254 1919 5338538
SGTC_2678 equilin 100 µM 0.194969239271944 0.420933578059761 no 1347 0.422708514488998 2060 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1249 0481-0015 10.2 µM 0.193956375161029 0.421272283155193 no 1348 0.423105020374271 1939 4227577
SGTC_1443 4112-3303 14 µM 0.192046277468689 0.421911184478177 no 1349 0.423852977929496 1951 704433
SGTC_2945 9067681 61.76 µM 0.19171812203334 0.422020968683446 no 1350 0.423981504988437 2048 16456930
SGTC_1550 gossypolone 36.6 µM 0.190931102892528 0.422284290146433 no 1351 0.424289785912264 2078 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_446 go6976 132 µM 0.18900929717575 0.422927435126107 no 1352 0.425042765018873 2095 3501 A protein kinase C inhibitor.
SGTC_3245 9134821 49.47 µM 0.188573354709407 0.423073354804838 no 1353 0.425213608983693 1923 17014901
SGTC_2921 7974240 10.71 µM 0.188390006447158 0.423134728716553 no 1354 0.425285466571285 2011 2979074 YDR527W RBA50
SGTC_3062 9077494 49.47 µM 0.18820598639411 0.42319632937885 no 1355 0.425357589941891 2030 16459633
SGTC_338 4055-0136 114 µM 0.188007766424109 0.423262685559936 no 1356 0.425435281510578 1927 2900563
SGTC_2576 guaiol 23.12 µM 0.186120906571109 0.4238944400905 no 1357 0.426174973643855 2105 227829
SGTC_1087 pterostilbene 9.05 µM 0.186096467326433 0.423902624074993 no 1358 0.426184556095515 2058 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2706 st078239 82.5 µM 0.185852773312101 0.423984231830135 no 1359 0.426280109144824 2059 15434492
SGTC_999 SEC7.066 22.7 µM 0.184340760134046 0.424490644450574 no 1360 0.426873069914205 1992 740511 YDR170C SEC7
SGTC_796 1234-0020 70.7 µM 0.183724511811148 0.424697077883715 no 1361 0.42711478929017 2082 46495034
SGTC_1851 st056236 18.9 µM 0.183061527208116 0.424919190293638 no 1362 0.427374871225182 2097 5393171
SGTC_2421 5690543 90.72 µM 0.18262735252635 0.425064659964027 no 1363 0.427545210530293 1973 3397993
SGTC_2305 7443522 69.23 µM 0.177722919389807 0.426708588035678 no 1364 0.429470292358779 2018 5415886
SGTC_536 3852-0578 10.6 µM 0.177537047422749 0.426770916117242 no 1365 0.42954328388443 2096 2869208
SGTC_202 3594-0513 34.79 µM 0.176526475561103 0.427109821151746 no 1366 0.429940175387985 2090 708429
SGTC_816 0325-0417 81.3 µM 0.174886300536964 0.427659984114396 no 1367 0.430584487482756 1964 68101
SGTC_3293 9120939 62.045 µM 0.173888053971693 0.427994894323281 no 1368 0.4309767205757 2035 934087
SGTC_507 nimesulide 162 µM 0.17274169780301 0.428379559061965 no 1369 0.431427233169802 2101 4495 A COX2 inhibitor.
SGTC_1471 k673-0312 37 µM 0.171713109057 0.428724764376813 no 1370 0.431831539679219 2107 24099884
SGTC_3220 9131269 49.47 µM 0.170733841853625 0.429053467537185 no 1371 0.432216525778948 2103 17722206
SGTC_3272 9137413 49.47 µM 0.170227477354751 0.429223454365034 no 1372 0.432415621633961 2130 17614870
SGTC_1372 2752-0194 270 µM 0.169744742911391 0.429385520792946 no 1373 0.432605442442519 2051 823334
SGTC_86 0417-1630 471.922 µM 0.168423874123531 0.429829031343702 no 1374 0.433124913769843 2117 3634867
SGTC_1938 st074717 56.4 µM 0.16782956810605 0.430028611494857 no 1375 0.433358680215855 2052 17250979
SGTC_1915 st067105 30.6 µM 0.166789120520622 0.430378058157503 no 1376 0.433767989671311 2076 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_3159 9100096 49.47 µM 0.164974910769202 0.430987512308444 no 1377 0.434481864876983 2091 25236875
SGTC_2285 7945142 200 µM 0.163083703619645 0.431623007451859 no 1378 0.435226265322014 2010 2970608
SGTC_1836 st055642 81 µM 0.162745146573199 0.431736790215859 no 1379 0.435359549498288 1918 8571
SGTC_1046 2001-0062 216 µM 0.162610234785076 0.431782133152228 no 1380 0.435412664031933 1980 739778
SGTC_963 1269-2853 151 µM 0.162317554134316 0.431880504221705 no 1381 0.435527895893979 1978 3668223
SGTC_1832 st054113 55 µM 0.159782586651923 0.432732692432514 no 1382 0.436526170836508 2131 1251267
SGTC_1408 3909-7976 48.8 µM 0.159237527412886 0.432915967774472 no 1383 0.436740869227323 2038 24152374
SGTC_1574 spiramycin 23.7 µM 0.158014128974531 0.433327386131291 no 1384 0.437222832637969 2101 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2382 9035899 200 µM 0.157640607846776 0.433453012489337 no 1385 0.437370001594649 1984 6462679
SGTC_2684 capsaicin 100 µM 0.157060058065491 0.43364828213519 no 1386 0.437598757939951 2056 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1665 st014639 11.4 µM 0.156796326339652 0.433736994438543 no 1387 0.437702684098362 2114 981133 YIL048W NEO1
SGTC_361 000s-0510 1.45 µM 0.155358314106591 0.434220761924222 no 1388 0.438269422805211 2035 660
SGTC_2043 5101342 149 µM 0.155351403080487 0.434223087128816 no 1389 0.438272146834181 2035 678451
SGTC_1082 camptothecin 424.86 nM 0.154987442101811 0.43434554447996 no 1390 0.438415608712989 1918 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3158 9100007 49.47 µM 0.153224187988322 0.434938893293412 no 1391 0.439110741820065 1993 19297233
SGTC_962 1254-0300 21.5 µM 0.152629114236342 0.435139173410897 no 1392 0.439345382077742 2029 7340576
SGTC_2265 7929201 200 µM 0.151241131817988 0.435606382249639 no 1393 0.439892752477921 2143 1265108
SGTC_3109 9122853 49.47 µM 0.1510054648789 0.435685719056124 no 1394 0.439985702492597 2075 1234709
SGTC_857 0438-0306 1.35 µM 0.148819601170049 0.436421708660999 no 1395 0.440847991688015 2064 4686136
SGTC_493 zm226600 134 µM 0.147099663027329 0.437000974054463 no 1396 0.441526677925331 2094 5240098 A potassium channel opener. YCR052W RSC6
SGTC_872 0588-0139 234 µM 0.146723006267364 0.437127847985786 no 1397 0.441675329376632 2162 2047100
SGTC_121 0557-0495 61.343 µM 0.146459505930846 0.437216609891485 no 1398 0.441779327370671 2124 3104427
SGTC_873 0591-4978 488 µM 0.145201421870179 0.437640447672688 no 1399 0.442275921671217 2164 3305145
SGTC_3114 9122766 49.47 µM 0.144307076942919 0.437941788390784 no 1400 0.442628995105081 2007 17176985
SGTC_306 1672-3436 11.6 µM 0.14363932193132 0.438166805346028 no 1401 0.442892644102874 2082 6797378
SGTC_2298 7976326 193.81 µM 0.141279519021392 0.438962160360811 no 1402 0.443824564386116 2101 2235818
SGTC_1984 st072354 53.1 µM 0.14057718002908 0.439198926538862 no 1403 0.44410198844368 2069 5762938
SGTC_590 k048-0076 22.4 µM 0.140535661779594 0.439212923477989 no 1404 0.444118389020239 2167 6832814
SGTC_935 2996-0153 430 µM 0.139877087519927 0.439434957052938 no 1405 0.444378552400973 2178 23738523
SGTC_1641 st009299 47.1 µM 0.139003349201506 0.439729561040715 no 1406 0.444723751231828 2173 4046054
SGTC_2180 6301957 200 µM 0.138931165745345 0.439753901097367 no 1407 0.444752271539911 2161 845462
SGTC_654 1124-0271 80.9 µM 0.138391850482577 0.439935763874649 no 1408 0.444965368708237 2010 5403748
SGTC_546 peri-Naphthalide 147 µM 0.137824910106927 0.44012695579452 no 1409 0.44518939840814 2124 223824 A penicillin ester.
SGTC_2854 9024559 71.43 µM 0.136146686397943 0.440692992590213 no 1410 0.445852660347497 2039 3163529
SGTC_747 3448-8087 38.7 µM 0.135412701282392 0.440940591660458 no 1411 0.446142791227637 2045 5168703
SGTC_3006 9075424 71.4286 µM 0.134004042883644 0.441415846422627 no 1412 0.446699688756363 2049 7465181
SGTC_2028 5153890 36.43 µM 0.133779212562928 0.441491707755142 no 1413 0.44678858269588 2082 2830968 YPR165W RHO1
SGTC_258 haloperidol 50.781 µM 0.132007957673584 0.442089432222569 no 1414 0.447488998761055 2001 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1050 3232-1156 69.3 µM 0.130791422636547 0.442500038408476 no 1415 0.447970154226192 2038 700529
SGTC_1907 st060210 83.7 µM 0.130280654780066 0.442672451751248 no 1416 0.448172192432932 2144 688793
SGTC_1632 st005650 90 µM 0.130084793044797 0.442738569162487 no 1417 0.448249670638042 2076 2759605
SGTC_2299 7976368 114.88 µM 0.129734973322386 0.442856662425112 no 1418 0.448388055840092 2157 2979718
SGTC_2792 7535235 81.82 µM 0.129083219935109 0.443076696954398 no 1419 0.448645899734729 2036 1281891
SGTC_3332 9141069 11.198 µM 0.127702578825476 0.443542864772529 no 1420 0.449192174598647 2072 17332883
SGTC_24 0417-1663 219 µM 0.127656962395054 0.443558268310583 no 1421 0.449210225188673 2066 4329390
SGTC_1682 st012968 530 nM 0.12745306228911 0.443627121365393 no 1422 0.449290910498285 1997 24207270
SGTC_157 1348-1695 65.819 µM 0.126946198876398 0.443798286538382 no 1423 0.449491490493862 2187 5380510
SGTC_2143 5623677 140.463 µM 0.126188966663169 0.444054019493509 no 1424 0.449791172438517 2165 5375313
SGTC_1761 st044296 37 µM 0.123654432949293 0.444910152752767 no 1425 0.450794445953397 2157 1826700
SGTC_2783 7738165 71.43 µM 0.123323690854975 0.445021892271276 no 1426 0.450925390717803 2034 17201110
SGTC_432 NS 1619 61.3 µM 0.121914955387406 0.445497875139345 no 1427 0.451483185647659 2062 4552 A K+/calcium channel activator.
SGTC_475 α-linolenic acid 10 µM 0.118965483685853 0.446494694907264 no 1428 0.452651350781858 2188 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_954 1189-0853 2.85 µM 0.118671901330712 0.446593934233952 no 1429 0.45276764934667 2219 2828194
SGTC_869 0564-0080 44.1 µM 0.117787869809079 0.446892782630363 no 1430 0.453117870563085 2024 6843321
SGTC_1056 3448-1962 115 µM 0.11601499019698 0.447492198396102 no 1431 0.453820330779766 2107 715507
SGTC_2189 6047310 154.431 µM 0.115546527337215 0.44765060714506 no 1432 0.454005971963244 2168 711535
SGTC_1042 0350-0096 82 µM 0.115058304274506 0.447815706609022 no 1433 0.45419945435905 2006 3122515
SGTC_530 4358-1714 28 µM 0.114665822291771 0.447948436443122 no 1434 0.454355002527092 2138 1564641
SGTC_1308 1187-1617 41.4 µM 0.114444730252838 0.448023208072163 no 1435 0.454442628643823 2142 2882570
SGTC_2557 derrustone 83.84 µM 0.114280327361188 0.448078809064449 no 1436 0.45450778840661 2021 629853 An antioxidant.
SGTC_2489 cantharidin 73.42 µM 0.114242673610218 0.448091543691595 no 1437 0.45452271234009 2200 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1004 4084-0029 199 µM 0.113250585098354 0.448427090647425 no 1438 0.45491594624293 2207 716894 YLR208W SEC13
SGTC_3026 9090633 49.47 µM 0.110961899959935 0.44920131650325 no 1439 0.455823279765187 2149 25236842
SGTC_125 0133-0007 11.75 µM 0.109670572137017 0.449638237768199 no 1440 0.456335319818063 2224 26541
SGTC_1400 3771-8998 51.5 µM 0.107532092184902 0.450361927323592 no 1441 0.457183433517819 2173 670767
SGTC_371 0195-0006 7.36 µM 0.107152202053761 0.450490504443525 no 1442 0.457334117132991 2146 3928593
SGTC_1123 mangostin 811.285 nM 0.106012870438548 0.45087615224911 no 1443 0.45778607030007 2071 5281650 An antioxidant.
SGTC_370 0180-0345 38.7 µM 0.105773501725921 0.450957181115726 no 1444 0.457881030691734 2136 3989527
SGTC_651 3253-0966 34.4 µM 0.10568171680531 0.450988251834256 no 1445 0.457917443490359 2140 781462
SGTC_1025 k007-0731 70 µM 0.10441200928113 0.451418099627847 no 1446 0.458421196373023 2109 6256118
SGTC_975 1335-0046 28.5 µM 0.104342480434616 0.451441639628585 no 1447 0.458448783683073 2102 16486740
SGTC_667 1498-1044 59 µM 0.104234457993069 0.451478212533651 no 1448 0.458491644687359 2142 6739982
SGTC_3029 9088683 49.47 µM 0.103934990993558 0.451579604526959 no 1449 0.458610469337048 2153 25236615
SGTC_1323 1348-1351 11.2 µM 0.101129928761648 0.452529480518177 no 1450 0.459723660057287 2091 6989654
SGTC_1509 1326-1131 80 µM 0.101106358027727 0.452537463415959 no 1451 0.459733015468186 2225 768313
SGTC_526 4469-0568 170 µM 0.100201181847947 0.45284404149563 no 1452 0.460092303879771 2169 2901964
SGTC_576 1073-0113 22.7 µM 0.100018730946635 0.452905839999621 no 1453 0.460164727432952 2256 5439563
SGTC_1993 st073995 70.8 µM 0.0995717927489398 0.453057228622956 no 1454 0.460342144316274 2152 3098394
SGTC_2514 salinomycin 42.74 µM 0.0983946792436363 0.453455977624138 no 1455 0.460809449764155 2244 23682228 A polyether potassium ionophore.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.0975409644859216 0.453745204188569 no 1456 0.461148402176273 2100 803109
SGTC_2090 5301565 104.445 µM 0.0969615002556426 0.453941532514574 no 1457 0.461378484342035 2166 2056344
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.0964572658717292 0.454112381369766 no 1458 0.461578706254013 2093 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1398 3558-0053 112 µM 0.0955029426804761 0.454435756246522 no 1459 0.461957676512352 2157 4532369
SGTC_2904 7225135 42.03 µM 0.095472170384563 0.454446184022217 no 1460 0.461969897042445 2248 4446116
SGTC_414 piperonyl butoxide 100 µM 0.0932367364639191 0.455203786702089 no 1461 0.462857745005125 2119 5794 A potent inhibitor of cytochrome P450.
SGTC_891 0929-0073 133 µM 0.092825010352409 0.455343341134164 no 1462 0.463021290701282 2213 5603632
SGTC_1113 artemisinin 1.17947 µM 0.0916419816116393 0.455744358949005 no 1463 0.463491247634281 2263 2240 An anti-malaria and mitochondrial poison.
SGTC_991 3996-0057 64.7 µM 0.091601368702077 0.455758126535137 no 1464 0.463507381978586 2163 715343
SGTC_2755 lomerizine 42.69 µM 0.0911229689922194 0.455920305790434 no 1465 0.463697440974836 2176 3949 A calcium channel blocker.
SGTC_189 3970-0742 2.116 µM 0.0911020911371404 0.455927383627293 no 1466 0.463705735533787 2257 2891807
SGTC_1688 st021091 57.6 µM 0.0910864551020255 0.455932684435085 no 1467 0.463711947581445 2255 3656366
SGTC_3179 9107801 49.47 µM 0.0905744687461488 0.456106258420821 no 1468 0.46391535975773 2219 4818259
SGTC_2130 NSC 7 2.4545 µM 0.0901389250142493 0.456253923368322 no 1469 0.464088408707574 2233 21448
SGTC_1003 4049-0218 100 µM 0.0888016866336332 0.456707332810589 no 1470 0.464619758624477 2198 295161
SGTC_2089 5281248 129.67 µM 0.0873830653240147 0.457188397885069 no 1471 0.465183514898859 2199 2737878
SGTC_1141 3253-0389 52.6 µM 0.0866363181730792 0.457441650667396 no 1472 0.465480298347087 2241 5402031
SGTC_3253 9135987 49.47 µM 0.0865480318577479 0.457471593345528 no 1473 0.465515387690588 2235 4182430
SGTC_2581 avocatin a 64 µM 0.0862093416557849 0.457586463801333 no 1474 0.465650002394707 2182 6710728 A skin care supplement.
SGTC_3222 9128301 49.47 µM 0.0850608850516376 0.45797600163695 no 1475 0.466106493384625 2211 4911358
SGTC_2261 9010538 184.68 µM 0.0849868983678177 0.458001098107047 no 1476 0.466135903305558 2095 6457250
SGTC_1936 st074407 74.3 µM 0.0837079359731929 0.458434951762477 no 1477 0.466644323649791 2251 809813
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.08365668235445 0.458452339212072 no 1478 0.466664699417296 2162 75037 A free radical scavenger.
SGTC_2329 6138490 200 µM 0.0830299567214335 0.458664958138026 no 1479 0.466913859914039 2123 720019
SGTC_455 paf C-16 10 µM 0.0823496119011144 0.458895780951398 no 1480 0.467184351882334 2241 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2836 9010338 19.48 µM 0.0814807625858506 0.459190578442174 no 1481 0.467529811617854 2170 2994051
SGTC_980 1473-0395 201 µM 0.0791793971252438 0.459971531598824 no 1482 0.468444965923365 2222 768876
SGTC_2824 7998404 51.95 µM 0.0782200844339769 0.460297113802892 no 1483 0.468826492947805 2217 837851
SGTC_433 pimozide 108 µM 0.0781837820620856 0.460309435029508 no 1484 0.46884093128214 2252 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2746 daunorubicin 9.88 µM 0.0781371471003778 0.460325263250411 no 1485 0.468859479198343 2260 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3143 9086658 49.47 µM 0.0775393861747283 0.460528152903714 no 1486 0.469097229967899 2121 25236626
SGTC_2695 st077686 51.995 µM 0.0761954223304162 0.460984353252646 no 1487 0.469631812277489 2194 2876092
SGTC_1279 0874-0590 65.2 µM 0.0750285590400687 0.461380479564863 no 1488 0.470095994549645 2214 3523074
SGTC_58 0957-0393 9 µM 0.074617309080483 0.461520099699552 no 1489 0.470259600930775 2250 6997992
SGTC_2231 micatex 6.853 µM 0.0744505943993146 0.461576700999317 no 1490 0.470325925981574 2203 20737 An antifungal of unknown mechanism.
SGTC_3260 9137109 49.47 µM 0.0736877458794768 0.461835705603572 no 1491 0.470629424825378 2269 17478346
SGTC_209 4077-0173 175.592 µM 0.0729473069511892 0.462087117117155 no 1492 0.470924024344266 2223 15993494
SGTC_77 0828-0286 12.516 µM 0.0725877574437306 0.462209205425695 no 1493 0.471067084581968 2278 745345
SGTC_2720 fluspirilene 36.88 µM 0.0724983844663276 0.462239553386793 no 1494 0.471102645548414 2243 3396 An atypical antipsychotic.
SGTC_130 0136-0219 337.655 µM 0.071780867792929 0.462483205096832 no 1495 0.471388149413848 2303 234244
SGTC_2622 2-methoxyxanthone 59.94 µM 0.0710807299084921 0.462720968951989 no 1496 0.471666752338893 2245 71034 A hepatoprotective.
SGTC_2947 9072639 7.68 µM 0.0706328859211313 0.4628730618603 no 1497 0.471844968293692 2238 16488146
SGTC_3241 9133421 49.47 µM 0.0703888833506969 0.462955930192187 no 1498 0.471942069551768 2259 17018221
SGTC_2172 5754775 163.918 µM 0.0701081721729761 0.463051267516591 no 1499 0.472053781128183 2206 2263357
SGTC_639 0833-0042 114 µM 0.0694478944343971 0.463275524560613 no 1500 0.472316553335313 2216 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_471 1-acyl-paf 4 µM 0.0679398022592707 0.463787777359046 no 1501 0.47291677715644 2267 16759367
SGTC_3162 9099653 49.47 µM 0.0674087840129823 0.463968162356195 no 1502 0.473128138232714 2298 25237511
SGTC_403 arphamenine a 50 µM 0.0668125885141667 0.464170696657599 no 1503 0.473365450809456 2281 5487158 An arginine aminopeptidase inhibitor.
SGTC_2663 amphotericin b 100 µM 0.0667304394140754 0.464198604357764 no 1504 0.473398150582553 2262 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1074 carmofur 3.8 µM 0.0659513249527294 0.464463293935419 no 1505 0.473708289046006 2299 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2481 5478948 45.16 µM 0.0657049987330243 0.464546981942853 no 1506 0.47380634630119 2200 77792
SGTC_1838 st055369 84.5 µM 0.0651228654623933 0.464744764814973 no 1507 0.474038087533301 2290 676036
SGTC_3311 9131146 2.8755 µM 0.0650434393743064 0.464771750926894 no 1508 0.474069706920069 2179 4900406 YPR165W RHO1
SGTC_1259 0671-0132 43 µM 0.0646562527751053 0.464903305246892 no 1509 0.47422384756349 2221 X1259
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.0643814381543947 0.464996681288937 no 1510 0.47433325478378 2245 5379071
SGTC_3084 9116877 49.47 µM 0.0642010395081149 0.465057977880861 no 1511 0.474405074848314 2301 27241325
SGTC_3087 9117406 49.47 µM 0.06180491079173 0.465872222408467 no 1512 0.475359096360099 2186 42546093
SGTC_1948 st076329 66.6 µM 0.0616847235977899 0.465913067814419 no 1513 0.475406952801808 2308 24208413
SGTC_233 rapamycin 362 pM 0.0604211428525231 0.466342515152472 no 1514 0.475910109928789 2297 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1898 st060199 18.6 µM 0.0599865222549266 0.466490236726394 no 1515 0.476083184520806 2299 688866
SGTC_465 cgp-37157 41 µM 0.0597638143387143 0.466565933879505 no 1516 0.476171873006315 2289 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2830 7992007 71.43 µM 0.058389562395396 0.467033060945822 no 1517 0.476719164295289 2302 1952075
SGTC_376 3970-0862 59.1 µM 0.0578356524202226 0.467221355412624 no 1518 0.476939769586117 2300 3135186
SGTC_1806 st050005 60.3 µM 0.05742421280533 0.467361223690131 no 1519 0.477103637896644 2228 5194765
SGTC_481 bay k-8644 50 µM 0.0572666438377498 0.467414790091538 no 1520 0.477166395545739 2227 2303 A calcium channel antagonist.
SGTC_21 0849-0113 22.993 µM 0.0570548953895005 0.467486776022257 no 1521 0.47725073306155 2283 1560156
SGTC_1959 st077091 55.8 µM 0.0565210143576868 0.467668278751919 no 1522 0.477463377623015 2301 821356 YKL052C ASK1
SGTC_1630 st005209 31.3 µM 0.055614653219569 0.467976428354559 no 1523 0.477824395495543 2311 3367314
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.0539336004371152 0.468548012510958 no 1524 0.478494033168362 2315 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2977 9011197 71.43 µM 0.0538420399990617 0.468579146360053 no 1525 0.47853050750098 2301 2704722
SGTC_1596 piperlongumine 63 µM 0.0537227698965576 0.468619702781979 no 1526 0.478578020620944 2310 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1744 st037937 38.9 µM 0.0536653652195092 0.468639222696047 no 1527 0.478600888784874 2270 1016152
SGTC_527 4476-4215 268 µM 0.0530913161611242 0.468834426753499 no 1528 0.47882957519791 2167 4418754
SGTC_1187 1391-0724 117 µM 0.0523556607503667 0.469084595624851 no 1529 0.479122651613296 2211 6997986
SGTC_2012 4023501 200 µM 0.0499750302576415 0.469894242114689 no 1530 0.480071143209716 2255 3477460
SGTC_1451 4152-0210 104 µM 0.0493511544941347 0.470106441427844 no 1531 0.480319726880159 2324 659563
SGTC_328 k915-0120 63.5 µM 0.0473856492983895 0.470775025350889 no 1532 0.481102933186643 2312 6624543
SGTC_1822 st052468 42 µM 0.0469530892633317 0.470922175587194 no 1533 0.481275307802993 2301 2873678
SGTC_3020 9089140 49.47 µM 0.0464016387181011 0.471109776291332 no 1534 0.481495065206694 2287 17217859
SGTC_1810 st050138 53 µM 0.0455418342450667 0.471402290227422 no 1535 0.481837715283519 2335 3444541
SGTC_2572 astragaloside iv 100 µM 0.0455202305883401 0.471409640203223 no 1536 0.481846324966713 2258 45006101 An anti-inflammatory agent.
SGTC_613 3914-0030 117 µM 0.0454417973705401 0.47143632476075 no 1537 0.481877582947828 2310 1145395
SGTC_777 1315-0167 517 µM 0.0447902158066853 0.471658010854629 no 1538 0.482137261961312 2160 4221767
SGTC_2502 avocadyne acetate 18.59 µM 0.0442978922467977 0.471825518792796 no 1539 0.482333475885256 2328 3952079
SGTC_2986 9022445 71.43 µM 0.0441924085254178 0.471861409174225 no 1540 0.482375516631261 2324 6459286
SGTC_694 1315-0438 43.2 µM 0.0439466367286023 0.471945032854418 no 1541 0.482473470226939 2280 6793154
SGTC_1363 1636-0063 10.4 µM 0.0434371134460609 0.472118401726872 no 1542 0.482676546678027 2328 6072185
SGTC_428 3448-4153 16.5 µM 0.043145736253883 0.472217547237699 no 1543 0.482792680482179 2318 3834874
SGTC_618 k072-0232 33.2 µM 0.0427632022669046 0.472347712843764 no 1544 0.482945148738889 2285 5872756 YGL099W LSG1
SGTC_2855 9016525 58.44 µM 0.0420338638296644 0.472595894466405 no 1545 0.483235851265721 2329 43811474
SGTC_2320 7373003 200 µM 0.042025481531167 0.472598746883849 no 1546 0.483239192366679 2289 5415828
SGTC_112 phenothiazine 287.218 µM 0.041901438258144 0.472640957808707 no 1547 0.483288634921198 2328 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1661 st013063 9.66 µM 0.0418147062117721 0.472670472206766 no 1548 0.483323205702579 2331 721395
SGTC_247 mechlorethamine 29.705 µM 0.0414806139616712 0.472784163207552 no 1549 0.483456373684215 2310 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_131 0141-0277 33.849 µM 0.0414243067031509 0.472803324686451 no 1550 0.483478817739161 2316 1547771
SGTC_2032 5185112 25.99 µM 0.0404576709450532 0.473132282651943 no 1551 0.48386412654199 2324 5718189
SGTC_2491 paeonol 100 µM 0.0394179796341324 0.473486122763006 no 1552 0.484278572687001 2278 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1213 1315-0166 115 µM 0.0390515488439259 0.473610835847458 no 1553 0.484424644948571 2196 768401
SGTC_1700 st030840 7.9285 µM 0.0385320208898119 0.47378765929881 no 1554 0.484631750727698 2330 5499307
SGTC_592 k241-0073 46.5 µM 0.0384063503718179 0.473830432547574 no 1555 0.484681848927357 2345 4230158
SGTC_2467 5474540 200 µM 0.0378167654992348 0.474031107821318 no 1556 0.484916888499102 2332 5413519
SGTC_741 4582-0002 126 µM 0.0376870708375349 0.474075252498901 no 1557 0.484968592325693 2325 2912688
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.0370585819101086 0.474289178224267 no 1558 0.48521914808723 2353 16623 A steroid.
SGTC_974 1326-0144 138 µM 0.0369351358909042 0.474331197783801 no 1559 0.485268362230717 2297 5411856
SGTC_1522 st012842 45.6 µM 0.0356256400842732 0.474776952100544 no 1560 0.485790431732313 2342 3491067 YOR116C RPO31
SGTC_648 0375-0473 33.3 µM 0.0353559194405128 0.474868769348135 no 1561 0.485897966953911 2316 1713139
SGTC_1610 st001799 48.1 µM 0.0352765944358821 0.474895773110459 no 1562 0.485929593323187 2326 621897
SGTC_1228 0124-0032 52.5 µM 0.0351366494207548 0.47494341337527 no 1563 0.485985388716521 2311 X1228
SGTC_473 2-arachidonoylglycerol 10 µM 0.0350521816790562 0.47497216816763 no 1564 0.486019065725013 2299 5282280 An endocannabinoid.
SGTC_3042 9091578 49.47 µM 0.0350421910541391 0.474975569218348 no 1565 0.486023048960634 2327 25236497
SGTC_2240 6690706 185.951 µM 0.0337130252878679 0.475428065603104 no 1566 0.486552996099885 2330 805876
SGTC_685 1278-0033 54.9 µM 0.0336933171202269 0.47543477522029 no 1567 0.486560854057017 2334 3590572
SGTC_1794 st048918 76.9 µM 0.0334541181079347 0.475516210733066 no 1568 0.486656226889207 2341 672303
SGTC_918 glabranin 770.725 nM 0.0326757145035485 0.475781225982541 no 1569 0.486966595282874 2312 124049 Also referred to as licorice root.
SGTC_2994 9053520 71.4286 µM 0.0318295019419483 0.476069339616971 no 1570 0.48730400970177 2343 4647384
SGTC_484 loperamide 105 µM 0.0297840695592737 0.476765808167404 no 1571 0.488119631890559 2349 3955 An opioid-receptor agonist.
SGTC_2073 5212005 126 µM 0.02961504184812 0.476823365210066 no 1572 0.488187034457786 2352 691789
SGTC_1446 4239-0190 62 µM 0.0293616120073579 0.476909663634889 no 1573 0.488288094387649 2333 1340085
SGTC_104 0074-0074 590.992 µM 0.0290053727539575 0.477030972751946 no 1574 0.488430152780258 2362 3943124
SGTC_1866 st057638 64 µM 0.0269976951256434 0.47771468085316 no 1575 0.489230786192974 2342 688802
SGTC_2531 methyl deoxycholate 70.07 µM 0.024793165497149 0.478465501748976 no 1576 0.49010997126376 2340 16667744 Haematoxylin.
SGTC_504 lovastatin 124 µM 0.024770544935439 0.47847320628311 no 1577 0.490118992791565 2336 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2698 st077697 67.5 µM 0.0232479550817315 0.478991816770844 no 1578 0.490726243153113 2335 3154499
SGTC_814 3342-0569 96 µM 0.0231902002234201 0.47901148940279 no 1579 0.490749277797869 2361 4346283
SGTC_2831 7999036 19.48 µM 0.0224494113396409 0.479263823637132 no 1580 0.491044732859534 2352 2988270
SGTC_3326 9140064 16.379 µM 0.022351221716551 0.479297270503902 no 1581 0.491083895025151 2357 1868434
SGTC_1032 k061-1018 98.7 µM 0.0212360911694123 0.479677133675537 no 1582 0.491528662088937 2361 4005393
SGTC_2386 9075165 157.42 µM 0.0209357282549159 0.479779453842799 no 1583 0.491648462918926 2362 16452277
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.0208875094101134 0.479795879963872 no 1584 0.491667695249259 2362 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2886 9058944 51.95 µM 0.0200685277325105 0.480074877601433 no 1585 0.491994353159147 2377 4949929
SGTC_792 4534-1957 155 µM 0.0192747899427625 0.480345284869452 no 1586 0.492310947451889 2284 1717904
SGTC_1779 st039427 55 µM 0.017595207151123 0.480917507772025 no 1587 0.492980890112774 2378 1124498
SGTC_2205 7238770 200 µM 0.0172137088984487 0.481047487260942 no 1588 0.493133062845283 2375 279867
SGTC_2017 5132927 60.65 µM 0.0159993549664518 0.481461240651701 no 1589 0.493617453145936 2370 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_429 1112-0049 25.5 µM 0.0156949789117837 0.481564950487522 no 1590 0.493738866376443 2367 2836170
SGTC_1047 2043-3044 82 µM 0.0153587196859712 0.481679525303718 no 1591 0.49387299822873 2373 669592
SGTC_713 1488-1073 324 µM 0.0110008137716545 0.483164543750525 no 1592 0.495611398784396 2386 3312542
SGTC_3325 9138760 55.175 µM 0.0090305369031915 0.483836021540011 no 1593 0.496397385980545 2381 43844959
SGTC_183 3914-0051 30.55 µM 0.00871418602519481 0.483943839433704 no 1594 0.49652358675341 2381 1596232
SGTC_2047 4141938 200 µM 0.00824051477906471 0.4841052770437 no 1595 0.496712547448738 2386 3807862
SGTC_1393 3470-5649 58.2 µM 0.0079047620068891 0.484219710574858 no 1596 0.496846489060302 2372 4108395
SGTC_1221 2958-7315 257 µM 0.00728339796244809 0.484431491493407 no 1597 0.497094370297398 2386 4562705
SGTC_2258 7960471 200 µM 0.00710676030970905 0.484491696110086 no 1598 0.497164836701278 2373 2974708
SGTC_3207 9114163 49.47 µM 0.00667188663944303 0.484639918574812 no 1599 0.497338322076516 2392 849233
SGTC_2095 5432005 200 µM 0.00614838349209039 0.484818352349098 no 1600 0.497547165322822 2396 783734
SGTC_1246 0422-0085 105 µM 0.00281205641069192 0.485955594868105 no 1601 0.498878153281432 2399 264295
SGTC_2915 7971052 15.16 µM 0.00218148195782508 0.486170549763662 no 1602 0.499129715303352 2400 5741558
SGTC_1360 1598-0022 39.8 µM 0.00209561228979119 0.486199821965117 no 1603 0.499163972266189 2402 761525
SGTC_2368 9071271 200 µM 0.000458464061726479 0.486757925188011 no 1604 0.49981709930814 2401 27209959
SGTC_1256 0570-0116 285 µM 0.000198230726765077 0.486846641052452 no 1605 0.499920917382337 2405 410638
SGTC_3055 9094636 49.47 µM 0.000177659966892009 0.486853653835745 no 1606 0.499929123928045 2405 25236176
SGTC_535 2293-4129 48.2 µM 0.00010283830568069 0.486879161342703 no 1607 0.499958973451891 2404 396118 YIL048W NEO1
SGTC_798 1287-0182 476 µM -0.000976011139172189 0.487246958606903 no 1608 0.499610627952261 2406 1649755
SGTC_3054 9094397 49.47 µM -0.00110758747742461 0.487291815861899 no 1609 0.499558136616355 2408 2598354
SGTC_2321 7390090 138.78 µM -0.00194949308959933 0.487578843702812 no 1610 0.499222265273842 2414 649046
SGTC_2393 9031399 185.94 µM -0.00325345118818645 0.488023410075746 no 1611 0.498702063053576 2408 1526623 YDL150W RPC53
SGTC_1653 st012112 65 µM -0.003310687643158 0.488042924393776 no 1612 0.498679229134694 2412 720429
SGTC_3103 9120822 49.47 µM -0.00431218180156362 0.488384380521719 no 1613 0.498279693690071 2414 17141819
SGTC_1546 5-methoxyflavanone 78.7 µM -0.00495187037561152 0.488602484701576 no 1614 0.49802449761366 2409 147795
SGTC_2820 7989630 71.43 µM -0.00613517792777492 0.489005946713531 no 1615 0.497552433481402 2417 2984098
SGTC_2099 5377090 177.372 µM -0.00694143928175288 0.489280857055223 no 1616 0.497230788622107 2431 2243829
SGTC_2774 tamoxifen 10.92 µM -0.00752787583828365 0.489480817103793 no 1617 0.496996840410822 2414 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_32 0928-0142 34.1 µM -0.0081693281815968 0.489699539171459 no 1618 0.496740945836344 2431 2244242
SGTC_237 nikkomycin 200 µM -0.00821426727762926 0.489714862596609 no 1619 0.496723018332423 2418 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1358 1509-0022 2.48 µM -0.00872450108967496 0.489888844227697 no 1620 0.49651947179449 2428 3258434
SGTC_220 paclitaxel 373.376 µM -0.00951496905305135 0.490158385043358 no 1621 0.49620413382434 2411 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_768 0384-0033 77.3 µM -0.00999478437106195 0.490321998949491 no 1622 0.496012724316291 2431 3965305 YMR134W ERG29
SGTC_2135 5326629 150.42 µM -0.0112435023610064 0.49074781123623 no 1623 0.49551458603354 2430 5020077
SGTC_2657 nystatin 74.44 µM -0.0123767958159024 0.491134272947657 no 1624 0.495062498912042 2437 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1180 1193-0155 285 µM -0.0125801689146991 0.491203625616681 no 1625 0.494981371100929 2447 2921347
SGTC_3352 9151559 45.5865 µM -0.0126584955167067 0.491230335999645 no 1626 0.494950125795684 2441 17159339
SGTC_1023 4482-3888 16 µM -0.0131261658496397 0.491389818437914 no 1627 0.494763567833036 2419 3303168
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.0135721045260621 0.49154189134514 no 1628 0.494585679892488 2444 115019
SGTC_1816 st051957 91.6 µM -0.0136135900199565 0.49155603868876 no 1629 0.494569131103844 2434 674121
SGTC_440 fluspirilene 35.1 µM -0.0136159372972618 0.491556839155349 no 1630 0.494568194762468 2502 3396 An atypical antipsychotic.
SGTC_478 N-arachidonylglycine 10 µM -0.0141467990173042 0.491737874052615 no 1631 0.494356431983303 2437 5283389
SGTC_1122 capsaicin 818.572 nM -0.0141476506972741 0.491738164494592 no 1632 0.494356092246154 2458 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2326 6164455 177.58 µM -0.0144253791709716 0.491832876367343 no 1633 0.494245305922451 2450 2888790
SGTC_483 fpl-64176 144 µM -0.0149148651883637 0.491999803608058 no 1634 0.494050050268255 2431 3423
SGTC_623 k072-0108 16.9 µM -0.0160023434600847 0.492370666460588 no 1635 0.493616261062084 2470 5382803
SGTC_1950 st077106 7.18 µM -0.0190629509905729 0.493414460192256 no 1636 0.492395443441129 2475 13831864
SGTC_1255 0566-0045 221 µM -0.0197473105059514 0.493647861508554 no 1637 0.492122474900008 2470 2788469
SGTC_1077 5-fluorocytosine 377 nM -0.0198452612789782 0.493681267871535 no 1638 0.492083405851457 2458 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3183 9108214 49.47 µM -0.0208268381693623 0.494016039601945 no 1639 0.491691894308265 2437 4974831
SGTC_1253 0550-0034 176 µM -0.0208568587171306 0.494026278328219 no 1640 0.491679920443382 2472 5969915
SGTC_1205 4161-2785 76 µM -0.0212092072691505 0.494146449658241 no 1641 0.491539384798383 2506 3498106
SGTC_2369 9071472 200 µM -0.0215858484368648 0.494274906768908 no 1642 0.49138916110714 2473 17296037
SGTC_753 1322-0200 289 µM -0.0218917055134707 0.494379222718546 no 1643 0.491267170616196 2488 5403907
SGTC_2765 myclobutanil 7.74 µM -0.0236830667690277 0.494990193836933 no 1644 0.490552706489564 2485 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2345 9052315 157.45 µM -0.0239234340318717 0.495072175689103 no 1645 0.490456840988114 2468 6469265
SGTC_1195 1502-0147 41.1 µM -0.024643283469738 0.495317695338631 no 1646 0.490169747277429 2442 817940
SGTC_3305 9127027 53.8275 µM -0.0253925760121002 0.495573259054972 no 1647 0.489870916342179 2472 41905295
SGTC_2655 perillic acid 100 µM -0.0268373822037609 0.496066048977927 no 1648 0.489294718630096 2458 5702197 An apoptosis inducer.
SGTC_1868 st057644 42.7 µM -0.0268884876852393 0.496083479988149 no 1649 0.489274337847665 2457 688665
SGTC_1314 1222-0010 41.1 µM -0.0272431780337903 0.496204457647473 no 1650 0.489132888691357 2473 3526027
SGTC_2084 5306078 60.6385 µM -0.0272792488942421 0.496216760703609 no 1651 0.489118503846246 2487 679340
SGTC_3210 9128157 49.47 µM -0.0280318765415972 0.496473467891865 no 1652 0.488818363663478 2531 17590849
SGTC_1716 st033144 30.6155 µM -0.0282358782933276 0.496543049322919 no 1653 0.488737010941901 2468 674617
SGTC_684 1140-0066 328 µM -0.0288782004527086 0.496762134859055 no 1654 0.488480865944282 2471 6813534
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.0306870963513547 0.497379124565013 no 1655 0.487759540968562 2470 5024745
SGTC_193 1273-0060 1.558 µM -0.0313119089060361 0.497592241132409 no 1656 0.487510396566033 2457 2847393 YHR072W ERG7
SGTC_2071 5230951 39.92 µM -0.0322534017830193 0.497913375090769 no 1657 0.487134984921087 2463 1799272
SGTC_941 3237-0776 460 µM -0.032435710492425 0.497975558960798 no 1658 0.487062292303296 2474 760008
SGTC_126 0417-1624 672.48 µM -0.0326204528527108 0.498038572977543 no 1659 0.486988629745507 2471 41912 YDL195W SEC31
SGTC_2990 9074105 71.4286 µM -0.0337216828270569 0.498414193931687 no 1660 0.486549544204177 2470 6502001
SGTC_3095 9117207 49.47 µM -0.0340281061071182 0.498518712786534 no 1661 0.486427369121124 2452 17015229
SGTC_2993 9054257 71.4286 µM -0.0343627575952301 0.498632860203203 no 1662 0.486293940527615 2468 6470217 YGL055W OLE1
SGTC_336 4111-0029 111 µM -0.034439143180852 0.498658914838974 no 1663 0.486263485114092 2511 3131175
SGTC_1317 1273-0028 910 nM -0.0345156639493198 0.498685015590485 no 1664 0.486232975882648 2474 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2475 5812728 15.03 µM -0.0350190130850186 0.498856704941184 no 1665 0.486032289960735 2454 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2175 5807670 165.306 µM -0.035948701445335 0.499173816560076 no 1666 0.485661631401877 2464 241186
SGTC_1729 st035615 45.989 µM -0.0365654617396422 0.499384190426255 no 1667 0.485415741321222 2583 17385451
SGTC_1102 cgs 12066b 26.1 µM -0.0366798848164718 0.499423219588746 no 1668 0.48537012371993 2523 6438352 A 5-HT1B full agonist.
SGTC_102 gallobenzophenone 83.616 µM -0.0373920695702285 0.49966614250059 no 1669 0.485086197908336 2477 70837
SGTC_1131 3454-3128 32.3 µM -0.037662572406814 0.499758409799146 no 1670 0.484978358851785 2606 710982
SGTC_522 1273-0010 11.6 µM -0.0383708495808205 0.5 no 1671 0.484696001261991 2667 5705015
SGTC_1344 1488-0097 29.1 µM -0.0386310380277912 0.499911250870713 no 1672 0.484592277994087 2517 747966
SGTC_1854 st056233 32.9 µM -0.0390749081072861 0.499759848760927 no 1673 0.484415333058162 2464 5393174
SGTC_2948 9070189 9.45 µM -0.042458788892165 0.498605624796202 no 1674 0.483066481902181 2497 6473636 YDL196W YDL196W
SGTC_1811 st050069 61.5 µM -0.0427497115474193 0.498506393013774 no 1675 0.482950525840059 2482 3877702
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0428110775339743 0.498485461495576 no 1676 0.482926066745746 2586 61125 An anti-inflammatory.
SGTC_1128 3448-9350 235 µM -0.0429284865639356 0.498445414090341 no 1677 0.482879270341026 2565 619386
SGTC_1412 3909-8563 178 µM -0.0430593517298629 0.498400776909 no 1678 0.482827110923371 2486 23767530
SGTC_1886 st057356 49.9 µM -0.0435616185913932 0.498229457430263 no 1679 0.482626923282241 2499 24207747
SGTC_3083 9117465 49.47 µM -0.0438568934431829 0.498128741531924 no 1680 0.482509238132345 2557 16420915
SGTC_196 k015-0023 18.111 µM -0.0439810534043624 0.498086391594081 no 1681 0.482459753222484 2481 5211998
SGTC_170 4197-0004 226 µM -0.0464010616769158 0.497260951642803 no 1682 0.481495295165127 2542 218692
SGTC_3091 9116372 49.47 µM -0.0471877949895251 0.496992607349647 no 1683 0.48118177743717 2622 17169793
SGTC_1837 st055472 66.5 µM -0.0499295855871935 0.496057430380051 no 1684 0.480089250405241 2604 676091
SGTC_2985 9022375 71.43 µM -0.0502921542366453 0.495933766045773 no 1685 0.479944787935932 2655 4939335
SGTC_1445 4239-0156 97.7 µM -0.051240649254703 0.495610256762517 no 1686 0.479566880475282 2591 4008346
SGTC_1394 3474-0001 65.7 µM -0.051405086539374 0.495554171370138 no 1687 0.479501365830861 2550 5017666 YIL048W NEO1
SGTC_2311 7694451 200 µM -0.0526951171936474 0.495114177728847 no 1688 0.478987414768676 2547 2163142
SGTC_672 1441-0018 53.7 µM -0.0528857451726963 0.495049160308703 no 1689 0.47891147110291 2516 251141
SGTC_2870 9038528 12.99 µM -0.0531326678581114 0.49496494266791 no 1690 0.47881310150919 2644 6463316
SGTC_2412 st077135 33.4 µM -0.0531649948399287 0.494953916957348 no 1691 0.478800223111635 2757 13258915
SGTC_2809 7964133 12.99 µM -0.0537326557645316 0.494760306414431 no 1692 0.478574082418475 2520 1253665
SGTC_2037 5169046 200 µM -0.0580427471133315 0.493290318998543 no 1693 0.476857289314496 2582 5718022
SGTC_2363 9053361 176 µM -0.0584201372890264 0.493161611434691 no 1694 0.476706987463579 2547 6469797 YMR079W SEC14
SGTC_1692 fluoroquinolonic acid 71 µM -0.059458543911809 0.492807470300632 no 1695 0.476293442096657 2617 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3011 9081274 71.4286 µM -0.0595243727240242 0.492785020044315 no 1696 0.476267226632598 2545 6625322
SGTC_635 k038-0028 24.7 µM -0.060843646166816 0.492335099979055 no 1697 0.475741865037038 2545 4035102
SGTC_856 0433-0016 11.3 µM -0.0608509826106446 0.49233259801251 no 1698 0.475738943632514 2570 3911780
SGTC_572 0960-0087 17.7 µM -0.0633999785896592 0.491463326222618 no 1699 0.474724002150784 2514 6796365
SGTC_2596 sinensetin 100 µM -0.0634829820543323 0.491435020611065 no 1700 0.474690955130455 2563 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1294 1000-1494 117 µM -0.0637071730879705 0.491358567821894 no 1701 0.474601696526854 2518 712797 YDL207W GLE1
SGTC_1635 st007035 42.4 µM -0.0640778702544032 0.491232154756134 no 1702 0.474454111302636 2508 3716403
SGTC_3292 9120825 59.784 µM -0.0641893934120663 0.491194123926993 no 1703 0.474409711404895 2519 24824900
SGTC_3153 9100258 49.47 µM -0.064456319456782 0.491103099043151 no 1704 0.474303443386018 2560 25236848
SGTC_540 1187-0821 17.3 µM -0.0646243552760991 0.491045797112953 no 1705 0.474236546266816 2527 847520
SGTC_1182 1222-0449 220 µM -0.0649506561915221 0.490934525697835 no 1706 0.474106643949729 2567 658318
SGTC_1148 3909-7663 27.7 µM -0.0652354314473809 0.490837415465559 no 1707 0.473993275491724 2656 4084526
SGTC_2137 5261020 140 µM -0.0661685348996142 0.490519224896752 no 1708 0.473621823684334 2535 763655
SGTC_1675 st018485 24.5 µM -0.0678873859123053 0.489933108421974 no 1709 0.472937640085319 2602 3323024
SGTC_3201 9113999 49.47 µM -0.0680550499901823 0.489875937257925 no 1710 0.472870906132337 2656 16649224
SGTC_2127 5253358 187.912 µM -0.0680558206993882 0.489875674457075 no 1711 0.472870599375052 2521 20612
SGTC_1745 st081495 74 µM -0.0689198621348135 0.489581051439693 no 1712 0.472526704206295 2552 13842402 YBL026W LSM2
SGTC_1783 st039459 87.517 µM -0.0696303007862154 0.48933880853685 no 1713 0.472243959462412 2689 729761
SGTC_1603 st002045 67.8 µM -0.0702889705778367 0.489114221111257 no 1714 0.471981830499507 2541 5887985
SGTC_1120 ficusin 1.78878 µM -0.0704284195735238 0.489066673460962 no 1715 0.47192633592801 2663 6199 A DNA cross-linker.
SGTC_197 4544-0043 41.561 µM -0.0721081257255081 0.488493959755385 no 1716 0.471257929833956 2537 896523
SGTC_2359 9039622 200 µM -0.0722199737587605 0.488455824806439 no 1717 0.471213424958444 2561 6463596
SGTC_2108 5365811 200 µM -0.0723019935622575 0.488427859956027 no 1718 0.471180789108823 2587 780283
SGTC_3250 9135583 49.47 µM -0.0726248950236675 0.488317766475836 no 1719 0.471052307831656 2658 7699353
SGTC_2388 9080168 200 µM -0.0756699283603417 0.487279605156737 no 1720 0.469840850534972 2542 15943073
SGTC_1039 k821-0043 94 µM -0.0770738518932677 0.486800985765212 no 1721 0.469282397138057 2526 15992768
SGTC_3165 9101544 49.47 µM -0.0793768174807356 0.486015910427688 no 1722 0.468366453710098 2609 5002184
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.0804053025993402 0.485665319690579 no 1723 0.467957454848678 2553 5106787 A p450 inhibitor.
SGTC_2898 9056270 58.44 µM -0.0805707376671143 0.485608927094644 no 1724 0.4678916692412 2532 19154699
SGTC_1608 st001473 40.5 µM -0.0822716900255372 0.485029132704596 no 1725 0.467215333085606 2565 7292267
SGTC_787 4152-0075 138 µM -0.0825509065468788 0.484933960677247 no 1726 0.467104319432409 2588 9566539
SGTC_1527 coumarin 137 µM -0.0826072456854122 0.484914757368639 no 1727 0.467081919873063 2782 323 A hepatotoxic, DNA x-linker.
SGTC_67 0335-0847 266 µM -0.0829637599922816 0.484793239563583 no 1728 0.466940177786786 2878 4552207 YOR254C SEC63
SGTC_2003 4023581 200 µM -0.0843826825194914 0.484309614310619 no 1729 0.46637608776129 2634 16641307
SGTC_1438 4092-1045 4 µM -0.0847700950655436 0.484177572682019 no 1730 0.46622208430994 2557 1351342
SGTC_1714 st033236 13.627 µM -0.0852305319663009 0.484020644456004 no 1731 0.466039058944105 2638 2916566
SGTC_1808 st050063 61.5 µM -0.0861926380861325 0.483692743033188 no 1732 0.465656641442906 2548 4011993
SGTC_2125 5246583 200 µM -0.0867873848110488 0.483490049172365 no 1733 0.46542025762438 2553 835267
SGTC_2242 6630449 61.2675 µM -0.0888989785496918 0.482770438021705 no 1734 0.464581097669373 2739 691249 YDR170C SEC7
SGTC_1060 3448-7350 82 µM -0.0891387021480447 0.482688745993237 no 1735 0.464485839967188 2600 570178
SGTC_1329 1447-1697 50.6 µM -0.0900380668516042 0.482382270670022 no 1736 0.464128482345004 2690 2840515
SGTC_604 1000-0114 314 µM -0.090438484124201 0.482245824342966 no 1737 0.463969388034874 2604 1572745
SGTC_140 0062-0056 502.533 µM -0.0904489612118849 0.482242254194825 no 1738 0.46396522534204 2542 3758964
SGTC_1919 st067113 52.3 µM -0.0905457153485902 0.482209284546549 no 1739 0.463926783762668 2668 1268243
SGTC_886 0866-0150 153 µM -0.0916628504407721 0.481828621826161 no 1740 0.46348295707028 2630 271463
SGTC_1974 st069448 26.9 µM -0.0917499565988367 0.481798941177381 no 1741 0.463448352560407 2613 6323587 YNR016C ACC1
SGTC_2350 9023895 38.85 µM -0.0933926575317564 0.481239224516044 no 1742 0.462795811732763 2658 2997209
SGTC_2246 7293507 91.5585 µM -0.0935669795505344 0.481179830013564 no 1743 0.462726570502465 2749 887656
SGTC_3086 9117350 49.47 µM -0.0939236464133915 0.481058308797636 no 1744 0.462584904873037 2571 2679265
SGTC_1206 3978-0017 132 µM -0.0947755775906054 0.480768051487106 no 1745 0.462246542896876 2833 3873677
SGTC_868 0527-0199 213 µM -0.0951687051831622 0.480634114333841 no 1746 0.462090413390993 2634 2849450
SGTC_1186 1319-0216 26 µM -0.0955828825700702 0.480493007956783 no 1747 0.461925930338337 2710 4565136
SGTC_2166 5933061 31.504 µM -0.0962906734095972 0.480251875879096 no 1748 0.461644859104311 2969 2877375
SGTC_2911 7942208 15.64 µM -0.0984083629824512 0.479530459231107 no 1749 0.460804017107784 2651 1243384
SGTC_926 2268-1401 59.4 µM -0.098850363438024 0.479379894791856 no 1750 0.460628540017292 2573 2931578
SGTC_435 c-PAF 6.7 µM -0.0995405746534086 0.479144784943521 no 1751 0.460354536967596 2576 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2450 5739737 12.93 µM -0.0995734592842747 0.4791335834796 no 1752 0.460341482752615 2645 2262825
SGTC_2215 7188065 200 µM -0.100288681568011 0.478889962011967 no 1753 0.460057571494758 2682 940217
SGTC_2919 7978188 46.38 µM -0.10045984926474 0.478831659450139 no 1754 0.459989628589252 2618 2980291
SGTC_2681 menadione 3.18 µM -0.105966556462623 0.476956232064954 no 1755 0.457804443412748 2625 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1514 1189-1591 158 µM -0.106195650297671 0.476878220008659 no 1756 0.457713560996301 2766 767698 YMR146C TIF34
SGTC_637 1181-0519 7.26 µM -0.107557343859455 0.476414548420829 no 1757 0.457173417646106 2598 6252091 YGR060W ERG25
SGTC_1845 st056753 3.01 µM -0.107585071056581 0.476405107335799 no 1758 0.457162419909796 2552 5375839
SGTC_2474 5321570 43.32 µM -0.109543307037921 0.475738363602241 no 1759 0.456385787185138 2742 2841384
SGTC_2965 9082772 38.63 µM -0.109626418018887 0.475710067314429 no 1760 0.456352829189864 2655 16459634
SGTC_3185 9108267 49.47 µM -0.110293995169744 0.475482785857214 no 1761 0.456088109685757 2648 4910486
SGTC_1220 1838-0075 193 µM -0.110334759526919 0.475468907595407 no 1762 0.456071945711789 2640 5529645
SGTC_377 3970-0964 33.1 µM -0.110985450414938 0.475247383341898 no 1763 0.455813942167339 2597 16481235
SGTC_2897 9048598 12.99 µM -0.112438393544629 0.474752764296563 no 1764 0.455237907338238 2618 6467404
SGTC_556 4058-0063 51.5 µM -0.112463271264279 0.474744295620427 no 1765 0.455228045116401 2618 6615692
SGTC_2996 9066192 71.4286 µM -0.113005174034069 0.474559828212846 no 1766 0.455013226603405 2636 6472854
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.113108315994901 0.474524718600852 no 1767 0.454972341047171 2781 165506
SGTC_1914 st062367 72.6 µM -0.113171201553773 0.474503312399707 no 1768 0.454947413395086 2643 978205
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.113425002314813 0.474416919543235 no 1769 0.454846809317646 2665 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3259 9138485 49.47 µM -0.117499117887449 0.473030272847195 no 1770 0.453232271513228 2669 17646153
SGTC_1031 k035-0009 16 µM -0.117520885619524 0.473022864947565 no 1771 0.453223647195466 2810 5180959
SGTC_1569 carminic acid 40.6 µM -0.120430129256034 0.472032888811393 no 1772 0.452071212694521 2664 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1089 terbinafine 2.25 µM -0.122109558417855 0.471461480111128 no 1773 0.451406126004217 2736 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2861 9024595 19.48 µM -0.122288439669191 0.471400621024766 no 1774 0.451335293545427 2583 16482810
SGTC_3116 9124943 49.47 µM -0.123025523150394 0.471149857102751 no 1775 0.45104344346875 2629 41905195 YPL160W CDC60
SGTC_2565 isoliquiritigenin 100 µM -0.123258981472033 0.471070434389761 no 1776 0.450951010564253 2785 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_200 k038-0079 37.545 µM -0.123794452939231 0.470888270907585 no 1777 0.450739011971642 2664 3436683
SGTC_2354 9060492 162 µM -0.123795185336654 0.470888021755494 no 1778 0.450738722017673 2736 6471895
SGTC_2332 7982454 138.89 µM -0.124638159997838 0.470601260303037 no 1779 0.450405008315455 2625 2981748
SGTC_2969 9091408 28.7 µM -0.124812999624491 0.470541785608613 no 1780 0.450335797830693 2670 4286311
SGTC_2126 5251174 33.877 µM -0.124822161382908 0.470538669097632 no 1781 0.450332171178798 2688 790722
SGTC_2760 etidronate 98.04 µM -0.124888538556042 0.470516089950083 no 1782 0.450305896117316 2669 3305 A chelator and antioxidant.
SGTC_589 1227-0070 34.1 µM -0.12629151473615 0.470038869767242 no 1783 0.449750586370294 2735 2841384
SGTC_2313 7726885 200 µM -0.126634551555655 0.469922192843057 no 1784 0.449614824445397 2730 726423
SGTC_2927 9011802 47.9 µM -0.126893495417873 0.46983412011996 no 1785 0.449512347464655 2726 43912568
SGTC_2457 5731572 11.68 µM -0.127113282763832 0.469759366580333 no 1786 0.449425369308887 2755 2865357
SGTC_2796 7949634 45.45 µM -0.128210086933398 0.469386340186464 no 1787 0.448991358866585 2616 2971588
SGTC_829 1635-0120 117 µM -0.128368447921143 0.469332483350778 no 1788 0.448928699726793 2770 285054
SGTC_1226 3909-7979 35.4 µM -0.129098345180254 0.469084260563812 no 1789 0.448639915703475 2757 6615510
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.131191105620863 0.468372623471533 no 1790 0.447812065916611 2747 521171
SGTC_3033 9090887 49.47 µM -0.132435369215421 0.46794956301413 no 1791 0.447319970230173 2658 19325384
SGTC_1290 0986-0249 10.2 µM -0.134670732246156 0.467189611359318 no 1792 0.446436107314943 2685 53329
SGTC_749 1000-0129 128 µM -0.136492272010377 0.466570434624699 no 1793 0.445716066710184 2789 708470
SGTC_2721 ifenprodil 61.44 µM -0.136518413835813 0.466561549095885 no 1794 0.445705734345706 2766 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_501 nsc-95397 161 µM -0.136523893636054 0.466559686530173 no 1795 0.445703568499588 2818 262093
SGTC_780 0109-0199 192 µM -0.136656400757175 0.466514648027444 no 1796 0.445651196639795 2838 610414
SGTC_2456 5770359 74.46 µM -0.137202722621979 0.466328960513364 no 1797 0.445435279461529 2801 3118787
SGTC_724 3910-0327 137 µM -0.137677929047718 0.466167450147096 no 1798 0.445247481666412 2691 2885483
SGTC_3267 9137951 49.47 µM -0.137728601154489 0.466150228337616 no 1799 0.445227457177523 2618 16643986
SGTC_2307 7538926 6.34 µM -0.138594258902313 0.465856029096673 no 1800 0.444885390129098 2717 96582
SGTC_598 3937-0236 20.2 µM -0.140193581253259 0.465312538515431 no 1801 0.444253521619753 2721 1379313
SGTC_738 1315-0003 72.4 µM -0.140718634573277 0.465134126044547 no 1802 0.444046111660168 2775 6251474
SGTC_1545 lovastatin 49.4 µM -0.141557488841606 0.464849098956389 no 1803 0.443714773841096 2700 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1660 st012960 28.1 µM -0.143152565079795 0.464307171570652 no 1804 0.443084845733217 2731 24207266
SGTC_392 N-ethylmaleimide 8.33 µM -0.143817276636416 0.464081355208837 no 1805 0.442822379960305 2695 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_182 3448-4371 550.524 µM -0.143958689319391 0.464033315864909 no 1806 0.442766545455983 2637 3491403
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.144457564391621 0.463863847060608 no 1807 0.442569581810134 2830 688798
SGTC_2890 9046729 58.44 µM -0.145124436952465 0.463637319437476 no 1808 0.442306312317023 2708 903329
SGTC_3225 9130819 49.47 µM -0.146862739026175 0.463046897244147 no 1809 0.441620181451372 2681 4547121
SGTC_880 0833-0487 87.2 µM -0.147487556398395 0.462834695004715 no 1810 0.441373600438672 2671 76075
SGTC_2819 7996655 46.38 µM -0.14829067195267 0.462561954175204 no 1811 0.441056688337435 2761 6456960
SGTC_1561 5-methoxyflavone 52.9 µM -0.148618642253724 0.462450579376838 no 1812 0.440927280994235 2646 94525
SGTC_1 0258-0098 57.368 µM -0.149854047583438 0.462031076978772 no 1813 0.44043988347143 2730 6790032 YDR047W HEM12
SGTC_1706 st031321 9.9705 µM -0.150176949866826 0.461921437088746 no 1814 0.440312505491417 2781 6103185
SGTC_1924 st058459 75.1 µM -0.151131608104242 0.461597304511397 no 1815 0.439935949600962 2654 688683
SGTC_1030 k029-0042 36.7 µM -0.152162581575501 0.461247289477663 no 1816 0.439529352913009 2723 6080581
SGTC_1420 4'-methoxyflavone 42 µM -0.153668852241631 0.460735965295957 no 1817 0.438935422665739 2670 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1708 st033234 31.827 µM -0.153782742052677 0.460697306470756 no 1818 0.438890520902376 2787 674664
SGTC_951 1171-0579 82.7 µM -0.154005050169268 0.460621847141967 no 1819 0.438802876816801 2644 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1431 4049-0260 9.09 µM -0.155444556684636 0.460133261564693 no 1820 0.438235429939724 2645 3854841
SGTC_1942 st076330 65.2 µM -0.15822624055569 0.459189296257249 no 1821 0.437139263613478 2843 24208414
SGTC_1204 4049-0315 18.3 µM -0.160427268358335 0.458442539533006 no 1822 0.436272255377622 2958 588402
SGTC_760 0568-0725 82.9 µM -0.16079067787947 0.458319257304297 no 1823 0.436129133838089 2849 3916171
SGTC_416 estradiol valerate 100 µM -0.161895861947622 0.457944361832547 no 1824 0.435693930759515 2752 13791 A steroid.
SGTC_167 3672-0051 66.205 µM -0.163632442730913 0.457355362567447 no 1825 0.435010251662117 2677 3237971
SGTC_2800 7887935 81.82 µM -0.163704035271704 0.457331082396352 no 1826 0.434982070360072 2851 2961002
SGTC_2555 cholic acid 100 µM -0.163725289696523 0.457323874119195 no 1827 0.434973703946372 2860 6708657 Influences liver metabolism.
SGTC_1678 st019265 80.2 µM -0.164006948648333 0.457228352946163 no 1828 0.434862836827228 2888 5367020
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.164660128644562 0.45700684449418 no 1829 0.43460575062911 2688 364106
SGTC_2211 7117706 200 µM -0.164946435324412 0.456909755480093 no 1830 0.434493071417522 2743 822771
SGTC_2643 anethole 100 µM -0.167372466225568 0.456087171713769 no 1831 0.433538494166195 2724 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1721 st082152 9.2685 µM -0.1678179008331 0.455936160478137 no 1832 0.433363269696197 2679 5296051
SGTC_698 k064-0052 127 µM -0.167959099575146 0.455888292609812 no 1833 0.433307727856357 2665 5088751
SGTC_1357 1503-1303 39.5 µM -0.168192205419947 0.455809268662083 no 1834 0.433216036384721 2728 292895
SGTC_2970 9090938 41.86 µM -0.168786350393514 0.455607858711766 no 1835 0.432982347544704 2913 17217104
SGTC_115 0527-0192 112.043 µM -0.170243601628424 0.455113911696762 no 1836 0.432409281517006 2781 4233931
SGTC_1350 1495-0454 146 µM -0.170747746212462 0.454943043955282 no 1837 0.432211059010668 2853 1069057
SGTC_1053 3366-3204 134 µM -0.172600126625515 0.454315295768817 no 1838 0.431482876179381 2753 3632071 YPR165W RHO1
SGTC_655 k060-0012 42 µM -0.172681722254072 0.454287646659144 no 1839 0.431450805740104 2725 5994525
SGTC_827 3253-0474 693 µM -0.173105389435611 0.454144088361086 no 1840 0.43128429437491 2783 5402065
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.173199134799134 0.454112323846898 no 1841 0.431247451847232 2847 551469
SGTC_2206 7254556 146.969 µM -0.174524068529765 0.453663417112021 no 1842 0.430726808532766 2765 4398905
SGTC_2054 5233173 129 µM -0.174643500870836 0.453622954605303 no 1843 0.430679882539713 2849 6889
SGTC_2942 9052777 62.25 µM -0.177032379740529 0.452813727523622 no 1844 0.429741477949903 2747 6469503
SGTC_1686 st019653 115.5 µM -0.17790224011774 0.452519112858653 no 1845 0.429399875775918 2760 97252
SGTC_1570 verbenone 133 µM -0.17867605490433 0.452257050021521 no 1846 0.429096036007851 2876 29025 A natural terpanoid with antifungal properties.
SGTC_406 estrone 100 µM -0.179173202811385 0.452088695129247 no 1847 0.428900852139885 2894 5870 A steroid.
SGTC_1015 4130-4525 82 µM -0.179581289462457 0.451950506507299 no 1848 0.428740647356375 2739 1363237
SGTC_2619 obliquin 87.91 µM -0.179937866550305 0.45182976511138 no 1849 0.42860067357063 2738 6708593 A bioactive alkalod. YER133W GLC7
SGTC_934 2950-0684 338 µM -0.179996754080664 0.451809825496317 no 1850 0.428577558225003 2946 1121253
SGTC_2874 9043904 71.43 µM -0.180426638891905 0.451664268015152 no 1851 0.428408821337417 2811 4463428
SGTC_1092 toremifene 6.32 µM -0.181445147849463 0.451319430443965 no 1852 0.428009092041932 2707 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1296 1068-0102 11.9 µM -0.181558912274281 0.45128091538755 no 1853 0.427964448045754 2844 767053
SGTC_2346 9031566 143.75 µM -0.182892518347599 0.450829456053914 no 1854 0.427441176689566 2847 4771086
SGTC_16 erodoxin 22.806 µM -0.183323135450432 0.450683694846681 no 1855 0.4272722412675 2758 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_808 0711-0032 135 µM -0.18396728433395 0.45046566688327 no 1856 0.427019560083066 2687 4252555
SGTC_272 doxorubicin 8.13 µM -0.187474281470165 0.449278901736337 no 1857 0.425644393298021 2712 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1738 st035555 74 µM -0.187888997646344 0.449138591884807 no 1858 0.425481833871855 2846 5331140
SGTC_622 1348-1566 26.3 µM -0.188655251215567 0.448879364040468 no 1859 0.425181513025185 2818 7340407
SGTC_1701 st028638 40.4 µM -0.188990957967193 0.448765799447118 no 1860 0.425049951791884 2833 3490878
SGTC_2564 betulinic acid 100 µM -0.189379293579463 0.448634436531157 no 1861 0.424897776072662 3000 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2529 gangaleoidin 93.61 µM -0.189868020118451 0.448469122218763 no 1862 0.424706276419078 2747 4565183
SGTC_2377 9073351 62.6 µM -0.191305685938789 0.447982876202241 no 1863 0.424143053313896 2726 7337946 YHR072W ERG7
SGTC_2391 6285546 200 µM -0.194047218148666 0.44705585489472 no 1864 0.423069454886479 2723 846083
SGTC_1998 st075797 76.8 µM -0.194228361538898 0.446994613224817 no 1865 0.422998538207413 2700 24208315
SGTC_421 streptovitacin 30 mM -0.19445329320352 0.446918569202194 no 1866 0.422910482123431 2948 91467 include heat shock
SGTC_2067 5224629 34.075 µM -0.195282266133851 0.44663833012863 no 1867 0.42258598969116 2908 2835000
SGTC_2790 5423970 71.43 µM -0.195537409270803 0.446552082877974 no 1868 0.422486127247972 2912 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1375 2910-0797 186 µM -0.197235619243335 0.4459780934758 no 1869 0.421821578963924 2827 742508
SGTC_3160 9100216 49.47 µM -0.197622036242358 0.445847501562761 no 1870 0.421670396196603 2710 17191039
SGTC_1383 3049-0032 20.7 µM -0.198180774647683 0.44565868300207 no 1871 0.421451814385545 2911 712864
SGTC_1229 0139-0193 12.2 µM -0.19882169153061 0.445442108446244 no 1872 0.421201113669517 2862 3090752
SGTC_1427 4048-4900 550 nM -0.198852332113081 0.445431754982799 no 1873 0.421189129114451 2882 24132586
SGTC_2353 9059630 146.67 µM -0.199165668723365 0.445325880571003 no 1874 0.421066576895459 2869 4779114
SGTC_3016 9080866 49.47 µM -0.201406405660081 0.444568864164242 no 1875 0.42019040342411 2790 17066299
SGTC_468 gf-109203x 121 µM -0.201641287433411 0.444489522751759 no 1876 0.420098582717944 2850 2396 A protein kinase C inhibitor.
SGTC_3328 9140624 29.0385 µM -0.203143064180167 0.443982285827574 no 1877 0.419511606523602 2941 4904392
SGTC_627 1391-0720 175 µM -0.203286311240349 0.443933907784904 no 1878 0.419455627099614 2857 997839
SGTC_1667 st014849 34.6 µM -0.203392443226073 0.443898064951191 no 1879 0.419414152902272 2725 5348460
SGTC_658 3253-0951 102 µM -0.20490818234221 0.443386220617577 no 1880 0.418821931139294 2815 1184878
SGTC_114 0364-0001 490.298 µM -0.205975148298924 0.443025977420367 no 1881 0.418405161924179 2823 4003655
SGTC_1000 4048-0884 8.67 µM -0.206987946711711 0.442684066548497 no 1882 0.41800963589619 2898 13040088
SGTC_537 1334-0398 209 µM -0.207524811075569 0.442502843665267 no 1883 0.417800008985827 2919 5846986
SGTC_656 4090-1979 187 µM -0.208442029897956 0.442193256930664 no 1884 0.417441920918594 2886 22330961
SGTC_2583 asiatic acid 100 µM -0.208530520282526 0.442163390841303 no 1885 0.417407377325297 2930 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1200 1643-0193 18.4 µM -0.208811669759985 0.442068503217682 no 1886 0.417297630499782 2758 5403974
SGTC_1713 st033146 12.748 µM -0.208834980683388 0.44206063595713 no 1887 0.417288531359428 2888 674619
SGTC_95 0471-0001 561.058 µM -0.209339948707627 0.441890218678285 no 1888 0.417091434006963 2794 4015405
SGTC_1773 st048542 73.5835 µM -0.209626183220829 0.441793624648994 no 1889 0.416979721201941 2762 3237138
SGTC_458 nppb 133 µM -0.21279554530911 0.440724309602764 no 1890 0.415743219250721 2956 4549 A chloride channel blocker.
SGTC_2225 6654152 15.4 µM -0.215946386886727 0.439661671465903 no 1891 0.414514769264067 2813 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_316 k060-0003 58.6 µM -0.217160066318802 0.439252467118632 no 1892 0.414041802255928 2930 6152314
SGTC_2666 tannic acid 100 µM -0.217772891423189 0.439045871544078 no 1893 0.413803033579674 2866 16134267 A thiamine antagonist.
SGTC_811 0416-0114 265 µM -0.219092277064104 0.438601136735821 no 1894 0.413289083322687 2879 6612453
SGTC_185 k048-0037 25.491 µM -0.219134868853972 0.438586781303394 no 1895 0.413272494691435 2913 6827589
SGTC_3296 9122258 64.045 µM -0.220615670099402 0.438087732141151 no 1896 0.412695849351658 2904 4730474
SGTC_3320 9137005 35.139 µM -0.220945793513099 0.437976489675165 no 1897 0.412567320171416 2843 4908713
SGTC_2703 st077852 53.4 µM -0.222113776337783 0.437582951150948 no 1898 0.412112656869911 2954 6281836
SGTC_2395 5646831 180.19 µM -0.223706045298602 0.43704655376271 no 1899 0.41149302084466 2962 6808628
SGTC_2888 9058547 12.99 µM -0.223808355899714 0.437012091710206 no 1900 0.411453213910619 2812 16476514
SGTC_1490 4089-0339 670 nM -0.22428431014791 0.436851778733727 no 1901 0.411268041968456 2809 742542
SGTC_1320 1313-0481 95.3 µM -0.224635314216628 0.436733558661303 no 1902 0.411131495064617 2957 6813365 YLR208W SEC13
SGTC_1153 4055-0057 267 µM -0.225441217252738 0.436462147547275 no 1903 0.410818025032786 2805 882706
SGTC_2218 6965428 192.983 µM -0.226722274437222 0.436030776168451 no 1904 0.410319852800393 2799 675684
SGTC_3028 9087778 49.47 µM -0.228179947428524 0.435540025379252 no 1905 0.409753174948101 2802 17217395
SGTC_2955 9076254 12.21 µM -0.22888245212995 0.435303550433929 no 1906 0.409480139867779 2920 16459619
SGTC_3030 9087619 49.47 µM -0.229124019666337 0.435222240063184 no 1907 0.40938626250199 2855 25236973
SGTC_1337 1486-1011 40.3 µM -0.229308500446913 0.435160146640554 no 1908 0.409314573545905 2810 X1337
SGTC_2288 7946289 167.31 µM -0.229449377506433 0.435112730643302 no 1909 0.409259830972774 2994 1246052
SGTC_848 0368-0089 85.6 µM -0.229566066768689 0.435073456412059 no 1910 0.40921448873077 2930 762535
SGTC_2179 6298986 200 µM -0.230079618176884 0.43490061747689 no 1911 0.409014951203629 2949 738374
SGTC_1409 3909-8004 61.9 µM -0.230173607713978 0.434868986056573 no 1912 0.408978434645466 2845 2119279
SGTC_1631 benzylvanillin 81.9 µM -0.23057705595876 0.434733213542652 no 1913 0.408821697012888 2960 75506
SGTC_3224 9130643 49.47 µM -0.2307534894426 0.434673840766936 no 1914 0.408753158064396 3008 17644395
SGTC_2794 7785382 27.27 µM -0.232203397524921 0.43418597871443 no 1915 0.408190019514017 2816 2205081
SGTC_1029 k015-0030 64.7 µM -0.233078332421298 0.433891630880982 no 1916 0.407850289906214 2923 2208316
SGTC_2309 7664088 163.95 µM -0.233347366095145 0.433801129245804 no 1917 0.40774584038535 2961 704922
SGTC_1654 st012436 41.8 µM -0.234256661680542 0.433495272293427 no 1918 0.407392864422342 2857 4323132
SGTC_3098 9119039 49.47 µM -0.234319446286616 0.433474155096767 no 1919 0.407368495078615 2803 17161528
SGTC_2337 9009472 200 µM -0.234494523970876 0.433415269852056 no 1920 0.4073005419669 3005 5742383
SGTC_2109 5483026 200 µM -0.236178680115344 0.432848900147815 no 1921 0.406647011201464 2864 759335
SGTC_1694 st024011 44.9 µM -0.237654139443495 0.432352826993294 no 1922 0.406074678013761 2844 2787533
SGTC_965 1291-5240 308 µM -0.237773462094604 0.432312713448594 no 1923 0.406028401308028 2947 2834598
SGTC_169 k015-0017 16.025 µM -0.237940471170839 0.432256569990797 no 1924 0.405963632660161 3023 1840002
SGTC_2064 5220758 200 µM -0.238216659798471 0.432163726634465 no 1925 0.405856528177888 2992 788518
SGTC_638 3970-0837 4.09 µM -0.238392216324997 0.432104713634762 no 1926 0.405788451952259 2853 4118451 YLR208W SEC13
SGTC_181 1447-1644 8.07 µM -0.239101927370909 0.431866161041144 no 1927 0.405513273645862 2922 534600
SGTC_823 0417-1665 178 µM -0.23916171092044 0.431846067347249 no 1928 0.405490095728562 2932 3429856
SGTC_2302 7771753 200 µM -0.239380859868211 0.431772411270615 no 1929 0.405405135120344 2899 2203047
SGTC_3257 9139206 32.98 µM -0.23960815325559 0.431696020349307 no 1930 0.405317021749196 2941 4910041
SGTC_3176 9106582 49.47 µM -0.242494550292311 0.430726155728981 no 1931 0.40419848955267 2900 17018027
SGTC_2040 5100729 123 µM -0.243656095413302 0.430335979924253 no 1932 0.40374858970096 2839 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_111 0083-0039 52.457 µM -0.244232085406229 0.430142523738672 no 1933 0.403525539384285 2805 759313
SGTC_253 dyclonine 31.25 µM -0.245708583346111 0.429646693101075 no 1934 0.402953913656615 2851 3180 An oral anasthetic.
SGTC_1002 4049-0206 172 µM -0.245793002594964 0.429618347169355 no 1935 0.402921237025326 2830 4662749
SGTC_492 tmb-8 126 µM -0.245896888335381 0.42958346536096 no 1936 0.402881026320752 2911 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2714 st079313 56.9 µM -0.24591468470669 0.429577489912522 no 1937 0.402874138042132 2852 2939799
SGTC_2779 methotrexate 400 µM -0.245934151142963 0.429570953728523 no 1938 0.402866603381268 2917 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3106 9121286 49.47 µM -0.245966830391121 0.429559981163699 no 1939 0.402853954662735 3039 15943471
SGTC_308 4092-1169 104 µM -0.245998052223251 0.42954949799976 no 1940 0.402841870141657 2855 2268590 YDL196W YDL196W
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.246563526447048 0.429359640777216 no 1941 0.402623017408137 3042 94937 An inhibitor of serotonin biosynthesis.
SGTC_1387 3342-1166 1.8 µM -0.248734403538779 0.428630923807782 no 1942 0.401783117412318 2924 3418228
SGTC_3013 9080133 71.4286 µM -0.249401588462752 0.428407012862357 no 1943 0.401525078274365 3048 17050193
SGTC_1300 1094-0077 113 µM -0.250463621113909 0.428050636405702 no 1944 0.401114417209096 2852 5532636
SGTC_1515 3460-0031 42.1 µM -0.250643176120488 0.427990390586805 no 1945 0.401044998628259 2874 2876596
SGTC_1937 st074714 47.2 µM -0.25148399226717 0.427708295177999 no 1946 0.400719968460834 2813 17250970
SGTC_910 3454-3003 490 µM -0.253198097297126 0.427133324291081 no 1947 0.400057568379608 2962 820824
SGTC_1369 1866-0067 208 µM -0.256454882952175 0.426041311603306 no 1948 0.39879980695075 2987 3531355
SGTC_2798 7813637 45.45 µM -0.25645873824309 0.426040019243804 no 1949 0.398798318668076 2999 956368
SGTC_2693 st077581 40.7 µM -0.25657336520478 0.426001594687268 no 1950 0.398754069159387 2966 25238761
SGTC_3073 9114972 49.47 µM -0.256736331389592 0.425946967358369 no 1951 0.398691161474386 2984 41905075
SGTC_2704 st078022 71.1 µM -0.258963500442164 0.425200548606455 no 1952 0.397831701238842 3021 54697681
SGTC_690 glyoxal 20.3 µM -0.259033266222417 0.425177171452215 no 1953 0.397804786742992 2881 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_285 1486-1325 46 µM -0.259088459661068 0.425158677392233 no 1954 0.39778349436256 2976 22310230
SGTC_1996 st072960 66.8 µM -0.260165220242474 0.424797912525182 no 1955 0.39736816546741 2980 1719405
SGTC_2608 thymoquinone 42.66 µM -0.260602056730188 0.424651569928696 no 1956 0.397199701717114 2887 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2731 amoxapine 43.43 µM -0.260917418382758 0.424545928515587 no 1957 0.397078096031368 2889 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1106 tegaserod maleate 11.7 µM -0.26099634001115 0.424519491804027 no 1958 0.39704766485764 2917 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1049 3226-0134 66 µM -0.261037532469598 0.424505693526907 no 1959 0.397031781819782 2861 5702385
SGTC_751 0833-0568 350 µM -0.262201645284533 0.424115787860317 no 1960 0.396582992501549 2941 6954252
SGTC_2907 7721985 69.9 µM -0.263247939836395 0.423765407369515 no 1961 0.396179741391669 2930 3267881
SGTC_3075 9116269 49.47 µM -0.263696676266866 0.423615154089834 no 1962 0.396006828434303 3076 17015205 YNL244C SUI1
SGTC_1943 st076331 65.2 µM -0.264598172893896 0.423313333815088 no 1963 0.395659513900981 2972 24208415
SGTC_1035 k081-0041 55.2 µM -0.264939809752974 0.423198965843579 no 1964 0.395527915020712 3017 731709
SGTC_508 roscovitine 141 µM -0.265643225910413 0.422963507311605 no 1965 0.395256995896099 2856 160355 A CDKinase inhibitor.
SGTC_426 0988-0037 14.6 µM -0.267674052914192 0.422283871605141 no 1966 0.394475111989662 3067 5383008
SGTC_859 0439-0102 54.6 µM -0.268998411432025 0.421840786833507 no 1967 0.393965452560888 3009 610143
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.271906505314115 0.420868186582804 no 1968 0.392846954557016 2931 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2568 diosmetin 100 µM -0.272497028264973 0.420670747346862 no 1969 0.392619937977093 3060 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2144 5628481 200 µM -0.272574120577475 0.420644973279482 no 1970 0.392590303832965 2889 2818399
SGTC_2076 5212012 200 µM -0.273430603669192 0.42035865047842 no 1971 0.392261115222668 2843 604802
SGTC_2416 tofa 880 nM -0.274667733735666 0.419945151595496 no 1972 0.391785761385083 2903 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.277416908907368 0.419026583090152 no 1973 0.3907299997627 2959 688761
SGTC_833 3852-0053 558 µM -0.2794792772579 0.418337783362848 no 1974 0.389938519518415 3066 3123681
SGTC_43 0570-0105 72.5 µM -0.279881926359259 0.418203333818541 no 1975 0.389784046984352 2899 1114046 YDL195W SEC31
SGTC_1288 0973-0013 65.5 µM -0.280586351899739 0.41796814036223 no 1976 0.389513842642121 2994 4315430
SGTC_1899 st063254 59.6 µM -0.281413607714374 0.417691973817026 no 1977 0.389196591114475 2866 3093813
SGTC_1830 st055982 50.3 µM -0.283913352278409 0.416857719961704 no 1978 0.388238391868987 3008 455313 An antimicrobial agent.
SGTC_430 0958-0115 16.4 µM -0.284085268153533 0.416800359219373 no 1979 0.388172518192155 2942 6833180
SGTC_88 0180-0332 8.668 µM -0.285323696959795 0.416387202578993 no 1980 0.387698079762952 2870 3101745
SGTC_2468 5987765 72.9 µM -0.286237277353385 0.416082478945905 no 1981 0.387348197197989 2963 26772094
SGTC_2455 5377712 9.75 µM -0.287716114486859 0.415589321595488 no 1982 0.386782026902445 2988 2243908
SGTC_179 1273-0063 6.77 µM -0.29104008406988 0.414481342310676 no 1983 0.385510331555585 2904 3108139
SGTC_1657 st012939 43.4 µM -0.291358520695108 0.414375233342166 no 1984 0.385388567351347 3076 24207257
SGTC_166 k072-0058 166.424 µM -0.291693902899948 0.414263484549901 no 1985 0.385260335689296 3014 5846229
SGTC_35 0133-0054 64.071 µM -0.293000279935117 0.413828268144775 no 1986 0.384760968860451 2953 99677
SGTC_987 1497-1013 404 µM -0.294017068415915 0.413489600684735 no 1987 0.384372430405732 2915 1676435
SGTC_2104 5389443 200 µM -0.294120154101897 0.413455268943854 no 1988 0.384333045452825 3092 2244536
SGTC_1505 k297-0037 20.6 µM -0.296580543977348 0.412636055624027 no 1989 0.383393383275773 2942 4089396
SGTC_409 arachidonic acid 100 µM -0.298277034304142 0.412071412239235 no 1990 0.382745865466719 2952 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.298705275631589 0.411928909270162 no 1991 0.382582465682658 2896 6312947
SGTC_1459 k035-0031 35.7 µM -0.298858295606205 0.41187799266384 no 1992 0.382524084439811 2898 3877128 YMR208W ERG12
SGTC_2916 7875993 68.79 µM -0.300344948550937 0.411383393924624 no 1993 0.381957025446305 2980 1299250
SGTC_675 1309-0189 238 µM -0.302031245614569 0.410822545491809 no 1994 0.381314122006545 2977 4246530
SGTC_7 0192-1582 4.227 µM -0.302460413633159 0.41067983681566 no 1995 0.381150553208819 2985 252616
SGTC_2014 4013930 200 µM -0.302964714563715 0.41051215975214 no 1996 0.380958376139462 2988 64556
SGTC_1777 st045864 34.765 µM -0.303692223821225 0.410270296069148 no 1997 0.380681191433991 3008 4691462
SGTC_1501 4491-0275 38.4 µM -0.30472344824603 0.40992751942083 no 1998 0.380288394661416 3051 5104718
SGTC_1573 oleylamine 1.06 µM -0.305582582787527 0.409641997597492 no 1999 0.37996124171326 2923 5356789 An amine of the fatty acid oleic acid.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.306054862501593 0.409485062178278 no 2000 0.379781437179478 3016 6708739 YPR165W RHO1
SGTC_348 k064-0012 10.7 µM -0.306821720923761 0.409230271110322 no 2001 0.379489537135324 2897 5066323
SGTC_853 0419-0306 21 µM -0.307970375493951 0.408848698857002 no 2002 0.379052437202026 2931 762713
SGTC_931 2812-0076 566 µM -0.308981899570264 0.408512751573161 no 2003 0.378667647820581 2917 3450959
SGTC_897 1000-0139 31.4 µM -0.309023780872575 0.408498843406379 no 2004 0.378651718530295 3096 6151020
SGTC_2930 9013230 14.89 µM -0.309449565456828 0.408357453129855 no 2005 0.378489785744351 3082 2995857
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.312436311856158 0.407365980663324 no 2006 0.377354478845717 2976 97141
SGTC_75 0159-0059 199.013 µM -0.312525520602442 0.407336376254657 no 2007 0.377320585510551 3252 5377270
SGTC_985 1493-0307 8.71 µM -0.31273511764454 0.407266822416817 no 2008 0.377240956423036 3099 3278274
SGTC_982 1491-0518 27.5 µM -0.313488569285004 0.407016817032994 no 2009 0.376954751872073 2954 3091256
SGTC_1322 1348-1070 12 µM -0.314525959869395 0.406672658894643 no 2010 0.376560801504401 3075 6758089
SGTC_3047 9092122 49.47 µM -0.314760825751732 0.406594751271059 no 2011 0.37647162872136 3024 17173831
SGTC_3231 9132313 49.47 µM -0.315146972333406 0.406466670195234 no 2012 0.376325032718335 3017 4905967
SGTC_1389 3405-0187 19 µM -0.31681185601753 0.40591455917012 no 2013 0.375693183739324 2996 799890
SGTC_896 0964-0007 44.5 µM -0.322309465895592 0.404092768687944 no 2014 0.373609131358722 3091 6756758
SGTC_2508 celastrol 40.54 µM -0.323400511281588 0.40373146543214 no 2015 0.373195971189851 3005 122724 Celastrol is a natural product and antioxidant.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.323762944594765 0.403611462610177 no 2016 0.373058756141891 3017 1241132 A phosphatase inhibitor.
SGTC_1861 st057647 17.4 µM -0.324547978895098 0.40335156638403 no 2017 0.372761602156538 3152 688668
SGTC_1616 st002734 56.1 µM -0.326418243671005 0.402732562091442 no 2018 0.372053968164345 2971 4026101
SGTC_616 4092-0450 108 µM -0.326662073563581 0.402651879279367 no 2019 0.371961744381329 3033 787165
SGTC_628 1636-0253 16 µM -0.329907104424449 0.401578501246449 no 2020 0.370735077608535 3074 4456143
SGTC_2465 5809242 33.21 µM -0.330098935013421 0.401515071463409 no 2021 0.370662603954562 2944 2731748
SGTC_1995 st072814 61.1 µM -0.331358080983352 0.401098792780607 no 2022 0.370187012259115 2997 5769371
SGTC_2343 7990716 14.84 µM -0.333400344365192 0.400423851232756 no 2023 0.369416051624725 2960 6456862
SGTC_110 0850-0284 111.64 µM -0.334487316291529 0.400064742187332 no 2024 0.369005930212927 2907 3906265
SGTC_2646 retinol 96.75 µM -0.334649061723196 0.400011312651187 no 2025 0.36894491536647 3076 445354 A vitamin A analog and teratogen.
SGTC_122 0236-0016 402.397 µM -0.334752899976736 0.399977012639685 no 2026 0.368905746448351 3043 6808838
SGTC_132 0417-1715 25.805 µM -0.339559887542343 0.398390010018172 no 2027 0.36709399505386 3145 6769098
SGTC_352 k048-0007 5.11 µM -0.340159505908305 0.398192166301456 no 2028 0.366868205690773 3096 6811911
SGTC_516 3992-2719 87.3 µM -0.340366052576822 0.398124022410713 no 2029 0.366790440145499 2930 5350887 YDR037W KRS1
SGTC_1176 0848-0131 83.3 µM -0.342232664002569 0.397508331009502 no 2030 0.366087902697314 3089 6769040
SGTC_779 1360-0071 233 µM -0.343245779630152 0.39717426721709 no 2031 0.365706783574937 3200 7566
SGTC_1252 0493-0875 34.8 µM -0.343275960433906 0.397164316583008 no 2032 0.365695432033555 2984 3960963
SGTC_1016 4226-1401 38 µM -0.343465867810809 0.397101705511596 no 2033 0.365624007162953 3042 2901613
SGTC_1364 1653-0028 37.6 µM -0.345545334548386 0.396416294388867 no 2034 0.364842217276499 3060 5718652
SGTC_854 0422-0053 192 µM -0.347371170222034 0.3958147461168 no 2035 0.364156244632882 3044 3596728
SGTC_1842 st055362 61.2 µM -0.347670206424925 0.395716247868479 no 2036 0.364043937116017 3016 676032
SGTC_1472 k841-0093 193 µM -0.348305173649552 0.395507120837279 no 2037 0.363805504409244 3140 X1472
SGTC_249 wiskostatin 11.211 µM -0.348631886215101 0.395399529475786 no 2038 0.363682843086419 3116 2775510 A n-wasp and actin depolymerizer.
SGTC_47 0149-0135 24.25 µM -0.352530080486939 0.394116412709649 no 2039 0.36222038178793 3017 5239155
SGTC_3340 9146634 11.102 µM -0.352556271898587 0.394107795499402 no 2040 0.362210562489483 3122 4907387
SGTC_407 eburnamonine 100 µM -0.352714528913461 0.394055728619668 no 2041 0.362151233028753 2993 3195
SGTC_2356 9061756 188.97 µM -0.353521106845986 0.393790392275224 no 2042 0.361848904016216 3084 20104043
SGTC_3168 9103419 49.47 µM -0.353837642029616 0.393686276571642 no 2043 0.361730280907513 3105 16649256
SGTC_1559 coumarin 343 70.1 µM -0.354417194294471 0.393495668200542 no 2044 0.361513125298519 3195 108770 A hepatotoxic, DNA x-linker.
SGTC_560 2332-1943 155 µM -0.354545064659011 0.393453616477863 no 2045 0.361465218855542 3023 21177716
SGTC_3258 9138477 49.47 µM -0.35576955862206 0.393050989765203 no 2046 0.36100657408023 3065 4970355
SGTC_2528 xanthyletin 44.79 µM -0.356806042308542 0.392710272208176 no 2047 0.360618506258724 3014 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_587 k089-0003 57 µM -0.356999169312703 0.392646795712207 no 2048 0.360546213804543 3074 9659696
SGTC_3126 9127922 49.47 µM -0.357963226553423 0.392329974547383 no 2049 0.360185416722472 3252 45595682
SGTC_2786 7743617 45.45 µM -0.359939907240515 0.391680595098556 no 2050 0.359446036345118 3062 583674
SGTC_2085 5307070 144.047 µM -0.360007515612747 0.391658389711326 no 2051 0.359420756618499 3007 2840351
SGTC_705 1124-0212 310 µM -0.360619935199137 0.391457261864657 no 2052 0.359191792315543 3194 9554485
SGTC_207 4185-0010 4.486 µM -0.360773915774249 0.391406696879579 no 2053 0.35913423180287 3125 3761753
SGTC_3039 9090270 49.47 µM -0.361194602524436 0.391268558816737 no 2054 0.358976988369094 3182 17173750
SGTC_1476 4112-3294 3.34 µM -0.361479608675623 0.39117498106589 no 2055 0.358870472926549 3167 704369
SGTC_928 2764-0428 58.7 µM -0.36205144744157 0.390987244874814 no 2056 0.358656792539481 3148 662578
SGTC_2740 felodipine 17.08 µM -0.364351067048051 0.390232530511202 no 2057 0.357797935313468 3115 3333 L-type calcium channel blocker
SGTC_2973 9094665 17.96 µM -0.364388441739701 0.390220267882598 no 2058 0.357783982619728 3237 25237061 YIL048W NEO1
SGTC_2458 5808907 16.39 µM -0.366261399778173 0.389605890868636 no 2059 0.35708501494923 3199 2731747
SGTC_2234 tolnaftate 200 µM -0.366509339903041 0.389524580952291 no 2060 0.356992522257785 3084 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_699 0375-0592 111 µM -0.367274880031471 0.389273558920045 no 2061 0.35670699480812 3182 762578
SGTC_397 arbidol 50 µM -0.368106384267067 0.389000959480327 no 2062 0.356396955331304 3201 131410 A RNA synthesis inhibitor.
SGTC_1525 8-methoxypsoralen 92.5 µM -0.368225962836252 0.388961761463142 no 2063 0.356352376373987 3275 4114 Related to psoralen; DNA damaging agent.
SGTC_3205 9113483 49.47 µM -0.369414215862659 0.388572311987551 no 2064 0.355909501734459 3215 17018033
SGTC_408 cantharidin 100 µM -0.369694708545021 0.388480396939887 no 2065 0.355804987440068 3077 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_636 0kpi-0074 126 µM -0.370234704215514 0.38830346257364 no 2066 0.355603810335724 3112 616434
SGTC_412 gemfibrozil 100 µM -0.372006942760157 0.387722935954404 no 2067 0.35494384008317 3129 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1981 st071826 47 µM -0.373109056127906 0.38736204657543 no 2068 0.354533639383752 3122 11838600
SGTC_1954 st077032 68.9 µM -0.373896583447115 0.387104228666667 no 2069 0.354240629211054 3131 698907
SGTC_2759 disulfiram 3.38 µM -0.375134897837801 0.386698934431337 no 2070 0.353780072148045 3024 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_499 genistein 192 µM -0.375144910920964 0.386695657701194 no 2071 0.353776348927442 3136 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_817 1391-0715 46 µM -0.377385242063461 0.385962724311846 no 2072 0.352943666317756 3114 1353946
SGTC_505 gw-5074 63.9 µM -0.378349649514682 0.385647339629703 no 2073 0.352585433392931 3166 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1930 st074634 34.3 µM -0.378441816518831 0.385617202732509 no 2074 0.352551204435476 3036 684253 YOR116C RPO31
SGTC_3017 9080681 49.47 µM -0.379375492351431 0.385311947047832 no 2075 0.352204523502593 3143 16451914
SGTC_1506 4226-2149 212 µM -0.380116113329921 0.385069859173236 no 2076 0.351929612613836 3166 991114
SGTC_2111 5486399 200 µM -0.380190456312159 0.385045561044755 no 2077 0.351902021535084 3084 689674
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.380916235652951 0.384808372338953 no 2078 0.351632702399572 3110 6708630 An antioxidant.
SGTC_155 k072-0202 43.6 µM -0.38163049544843 0.384574990366299 no 2079 0.351367730570655 3159 5857737
SGTC_773 4358-1457 44.6 µM -0.383453323293958 0.383979577292445 no 2080 0.350691836388911 3232 1186886
SGTC_940 3232-1287 54.8 µM -0.385945780088688 0.383165878226996 no 2081 0.349768412351367 3168 1585493 YIL048W NEO1
SGTC_1751 st044839 27.194 µM -0.386604762260202 0.382950829802622 no 2082 0.349524415910365 3141 5291326
SGTC_842 0271-0008 11.1 µM -0.388578443841511 0.38230696604641 no 2083 0.348794007675157 3219 1221709
SGTC_1724 st037281 8.293 µM -0.388883607250732 0.382207443183636 no 2084 0.348681124553765 3046 574124 YDL195W SEC31
SGTC_1874 staurosporine 7.6 µM -0.388936468839619 0.382190204238055 no 2085 0.348661571862747 3194 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_347 4534-1311 26.2 µM -0.389258125142877 0.382085312397621 no 2086 0.348542604796072 3075 2862016
SGTC_554 4483-2211 187 µM -0.389266843563204 0.382082469448772 no 2087 0.348539380428297 3164 747107
SGTC_674 0498-0004 451 µM -0.390442306069914 0.381699226659674 no 2088 0.348104754774292 3161 4231473
SGTC_80 0159-0065 512.242 µM -0.396518877859581 0.379719903499686 no 2089 0.345861142106299 3196 1548079
SGTC_3315 9136395 68.55 µM -0.39756900532867 0.379378162745281 no 2090 0.345473955672842 3296 16876844
SGTC_3313 9133968 57.047 µM -0.397653142493804 0.37935078623975 no 2091 0.345442940933044 3166 1494643
SGTC_49 0717-0965 32.132 µM -0.398702305457811 0.379009461005632 no 2092 0.345056284462281 3346 5889349 YGL099W LSG1
SGTC_1792 st045773 43.6 µM -0.401176615493494 0.3782048652014 no 2093 0.34414504808916 3075 2919270
SGTC_194 1486-1323 56.904 µM -0.40372271621631 0.377377475569994 no 2094 0.343208316565883 3157 5178754
SGTC_261 5-fluorouridine 15.376 µM -0.403835251757218 0.377340918587515 no 2095 0.343166935980309 3321 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2735 sertaconazole 140 nM -0.40493038620159 0.376985223429122 no 2096 0.342764340974689 3175 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3128 9127691 49.47 µM -0.406260094334477 0.376553480021621 no 2097 0.342275751604002 3214 41316314
SGTC_597 k018-0003 82.8 µM -0.407368916152609 0.376193574281344 no 2098 0.341868526664901 3249 6786234
SGTC_3022 9087993 49.47 µM -0.409181495606364 0.375605472036806 no 2099 0.341203236520298 3207 17173644
SGTC_1179 1021-1431 9.29 µM -0.409641561720389 0.375456246752218 no 2100 0.341034452018349 3194 2840958
SGTC_2662 daunorubicin 22.37 µM -0.410325944616593 0.375234297413955 no 2101 0.34078343125395 3144 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3270 9137563 49.47 µM -0.410592011251466 0.375148021607787 no 2102 0.340685861264352 3191 17015724
SGTC_27 0485-0001 32.618 µM -0.41063763677234 0.375133227525447 no 2103 0.340669130881011 3160 2054479
SGTC_152 4469-0003 551.229 µM -0.411359478053676 0.374899194831327 no 2104 0.340404481244605 3258 697280
SGTC_2429 5902844 64.44 µM -0.411720477948243 0.374782170060589 no 2105 0.340272156835558 3225 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_3290 9121031 71.43 µM -0.412258886799129 0.374607656330068 no 2106 0.340074839766006 3153 17014854
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.414429890403275 0.37390423275118 no 2107 0.339279651147753 3303 23847180
SGTC_3283 9109332 35.8195 µM -0.414640202869274 0.373836111991949 no 2108 0.339202656479885 3135 17027281
SGTC_45 0kpi-0036 14.9 µM -0.415905331111502 0.373426416855832 no 2109 0.338739639165538 3257 2795021
SGTC_1184 1269-1718 139 µM -0.416058975577323 0.373376670848043 no 2110 0.338683424247912 3267 5403821
SGTC_1312 1218-2183 165 µM -0.417694603696883 0.372847228752332 no 2111 0.33808520912512 3217 6744073
SGTC_105 0111-0055 734.78 µM -0.417819648099526 0.372806762565999 no 2112 0.338039492141874 3204 5179370
SGTC_1439 4092-1168 46 µM -0.418348470724964 0.372635643401809 no 2113 0.337846177836256 3205 2886240
SGTC_2451 5856223 45.7 µM -0.419228604472979 0.372350900906968 no 2114 0.337524534460564 3143 2179896
SGTC_763 3453-1109 128 µM -0.419696069087455 0.37219969425054 no 2115 0.337353748549813 3298 1560353
SGTC_362 0310-0100 9.03 µM -0.420648334145845 0.371891734440264 no 2116 0.337005946841076 3260 790235
SGTC_2272 7805186 180 µM -0.421201856267124 0.371712764607602 no 2117 0.336803844500437 3273 2956062 YPR165W RHO1
SGTC_1958 st076513 41.9 µM -0.421222804424642 0.371705992001995 no 2118 0.336796196821086 3115 732122 YGL099W LSG1
SGTC_36 0335-0881 14.2 µM -0.422134183152526 0.371411378844462 no 2119 0.336463539264987 3190 23828853
SGTC_1125 tnp00248 1.32998 µM -0.422718803330104 0.371222433610062 no 2120 0.336250217480444 3301 24207736
SGTC_600 1495-0418 41.6 µM -0.422781003149741 0.371202332880461 no 2121 0.336227524518581 3152 5377768
SGTC_1458 k015-0034 6.33 µM -0.423613882784642 0.370933210209271 no 2122 0.335923714507948 3199 3598957
SGTC_722 3534-0461 190 µM -0.424660575263136 0.370595089180301 no 2123 0.335542063848646 3184 658262
SGTC_3110 9122132 49.47 µM -0.424727488635395 0.370573477040578 no 2124 0.335517671297916 3317 918317
SGTC_2594 a-mangostin 100 µM -0.42663917127696 0.369956201441083 no 2125 0.334821081097009 3282 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1145 3546-0597 10.2 µM -0.427312300585063 0.369738929989131 no 2126 0.334575937350272 3191 875334
SGTC_2408 sulbentine 18.36 µM -0.427946909609075 0.369534130121358 no 2127 0.334344886685947 3123 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_815 1582-0027 36.9 µM -0.428219859036407 0.369446055758875 no 2128 0.334245529598716 3249 3128206
SGTC_765 1319-0117 244 µM -0.428904940558286 0.369225026245808 no 2129 0.333996202314763 3149 3487746 YGL099W LSG1
SGTC_3289 9119912 71.43 µM -0.430645595274942 0.368663629186929 no 2130 0.333363041419492 3273 17014829
SGTC_171 k064-0041 9.68 µM -0.431535107771298 0.368376851147774 no 2131 0.333039665478596 3162 53325
SGTC_2287 7945887 168.79 µM -0.433485600605238 0.367748270806886 no 2132 0.332331012404425 3231 1245853
SGTC_198 3454-2873 16.191 µM -0.433904496099848 0.367613320554295 no 2133 0.332178897340194 3179 710957
SGTC_2768 sulfasalazine 50.2 µM -0.435092904320299 0.36723055514957 no 2134 0.331747496828697 3328 5384001 An antioxidant and salicylic acid derivative.
SGTC_2149 5554786 194.827 µM -0.436924085370699 0.366641022236745 no 2135 0.331083201999869 3183 745063 YPR165W RHO1
SGTC_1875 nocodazole 6 µM -0.437169328557739 0.36656209216029 no 2136 0.330994275794633 3303 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3217 9129673 49.47 µM -0.438959788997556 0.365986014187655 no 2137 0.330345336500534 3327 17248312
SGTC_3344 9148862 3.898 µM -0.441625751051903 0.365128804794113 no 2138 0.329380023275832 3321 4905352
SGTC_2423 st077119 87.2 µM -0.447354037561799 0.363289223298439 no 2139 0.327309728120515 3244 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3180 9109287 49.47 µM -0.447898568858218 0.36311451578969 no 2140 0.327113200649857 3275 18891271
SGTC_723 4182-0001 115 µM -0.448535592389616 0.362910169204762 no 2141 0.326883352522849 3200 744821 YLR208W SEC13
SGTC_914 3820-6779 408 µM -0.448802507048332 0.362824559007752 no 2142 0.32678706502519 3147 2893481
SGTC_1793 st048256 72.231 µM -0.450337429360297 0.362332381276736 no 2143 0.326233577143492 3232 672022
SGTC_2414 st077232 92.9 µM -0.451044919168531 0.362105598953531 no 2144 0.32597858737852 3131 729801
SGTC_942 3253-1115 227 µM -0.452163758535086 0.361747059400107 no 2145 0.325575507265841 3362 46497897
SGTC_113 0099-0221 2.5 µM -0.45294137957537 0.361497936987771 no 2146 0.325295476676839 3351 89219
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.453499210732843 0.36131926367236 no 2147 0.32509465577606 3242 77254
SGTC_718 1130-0073 349 µM -0.453519979556263 0.361312612002136 no 2148 0.325087179917438 3370 6740020
SGTC_1503 4585-0012 61.3 µM -0.454209123500559 0.361091922359246 no 2149 0.324839158500164 3341 2922052
SGTC_2925 9010536 32.5 µM -0.455126809214743 0.36079811687866 no 2150 0.324509005913353 3221 2994177
SGTC_451 chloral hydrate 100 µM -0.455761796563079 0.360594867934476 no 2151 0.324280639418547 3285 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2690 usnic acid 100 µM -0.456360243895674 0.360403350885803 no 2152 0.32406547463923 3423 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2374 9071832 200 µM -0.456458762241942 0.360371826082092 no 2153 0.324030059144217 3319 17381698
SGTC_380 3970-0968 6 µM -0.457258479841074 0.360115960255318 no 2154 0.323742634646198 3150 2891601
SGTC_2521 angolensin 13.4 µM -0.457758860397907 0.359955897742998 no 2155 0.323562847561221 3326 821428 A flavenoid.
SGTC_2519 cryptotanshinone 88.04 µM -0.457983836420363 0.359883940062125 no 2156 0.323482026934921 3342 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_375 3970-0961 9.27 µM -0.458640434921514 0.359673958061028 no 2157 0.323246197415636 3231 2898222
SGTC_1160 4092-0570 10.5 µM -0.459330222316314 0.359453407781564 no 2158 0.32299852397376 3214 4994975
SGTC_1222 0366-0074 1.18 µM -0.45993647643105 0.35925960479833 no 2159 0.322780908575572 3339 286520
SGTC_1684 st024538 14.6195 µM -0.46033582812118 0.359131962680417 no 2160 0.322637594109428 3220 6732859
SGTC_855 0428-0020 25 µM -0.46686481878451 0.357047384103095 no 2161 0.320298298635305 3233 6812414
SGTC_447 ml7 120 µM -0.468241416478973 0.356608405235842 no 2162 0.319805978719109 3317 4216 Selective myosin light chain kinase inhibitor.
SGTC_1474 0330-0125 5.35 µM -0.469294512274657 0.356272715008505 no 2163 0.319429568630373 3330 X1474
SGTC_689 0833-0039 98 µM -0.469619077749568 0.356169277285318 no 2164 0.319313596035783 3284 5374726
SGTC_2605 digitonin 300 nM -0.471315457310747 0.35562882024956 no 2165 0.318707739488314 3415 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3281 9140613 49.47 µM -0.476677478619514 0.353922422519437 no 2166 0.316795901214943 3276 16013766
SGTC_1343 1487-0095 224 µM -0.477351271247907 0.35370820278466 no 2167 0.316556003538134 3359 4560101 YGL055W OLE1
SGTC_1929 genistein trimethyl ether 50.5 µM -0.478313535638846 0.35340234917799 no 2168 0.316213531921991 3402 136420
SGTC_273 hydroxyurea 18.1 mM -0.478703529776674 0.353278417345079 no 2169 0.316074777175391 3226 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_895 0964-0006 13.7 µM -0.480495976443643 0.352709016206967 no 2170 0.315437381752709 3363 6738897
SGTC_2588 indole-3-carbinol 100 µM -0.480925915495913 0.352572487755554 no 2171 0.315284576628156 3360 3712 Induces cell cycle arrest.
SGTC_1677 st019204 53.9 µM -0.48094273054374 0.352567148471814 no 2172 0.315278601014809 3302 3945625
SGTC_394 menadione 8.33 µM -0.482451839644942 0.352088079312064 no 2173 0.314742501388824 3336 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_585 0kpi-0023 191 µM -0.483158231755256 0.351863914558233 no 2174 0.314491694925323 3318 64601
SGTC_3104 9120930 49.47 µM -0.484036695954508 0.351585216693344 no 2175 0.314179913200421 3351 17014836
SGTC_1555 citronellol 128 µM -0.484624894277068 0.351398651931161 no 2176 0.313971225793745 3314 8842 A terpine precursor.
SGTC_1704 st028805 70.8 µM -0.488632487205863 0.350128478338013 no 2177 0.312550954353151 3317 2876101
SGTC_1159 4092-0538 61.2 µM -0.489523929649536 0.349846170193379 no 2178 0.312235408638103 3304 717301
SGTC_1819 st053448 58.6 µM -0.490539501319262 0.34952465308133 no 2179 0.311876092414169 3235 2857616
SGTC_2159 5658611 73.75 µM -0.490882675999262 0.349416032712845 no 2180 0.31175471529751 3387 793844
SGTC_2492 derrusnin 100 µM -0.496474001084445 0.347648030082662 no 2181 0.309780013031897 3301 1715307 Part of coumarin class of compounds.
SGTC_2686 alizarin 95.37 µM -0.498481746100426 0.347013977161991 no 2182 0.309072266013126 3285 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2237 6667747 47.222 µM -0.500701579959134 0.346313444154921 no 2183 0.308290580086525 3212 729940 YDL015C TSC13
SGTC_3045 9092950 49.47 µM -0.501274517129339 0.346132722414 no 2184 0.308088968500631 3421 44120432
SGTC_624 k048-0052 28 µM -0.503648167587045 0.345384374798169 no 2185 0.30725431896607 3294 6835531
SGTC_958 1222-0007 33 µM -0.504958186879833 0.344971619709825 no 2186 0.306794102153739 3432 7312461
SGTC_203 k066-0004 30.888 µM -0.505165664374162 0.344906265520984 no 2187 0.306721242097473 3397 6795412
SGTC_1327 1436-0082 2.18 µM -0.505289360520594 0.344867304164758 no 2188 0.306677807244921 3288 15992205
SGTC_2866 9034245 58.44 µM -0.505351433701353 0.344847753202933 no 2189 0.306656011796965 3306 6462273
SGTC_2134 5324836 1.464 µM -0.507683755446169 0.344113451018886 no 2190 0.305837571240741 3259 699272
SGTC_1531 st059297 52.4 µM -0.508021719389538 0.344007095981391 no 2191 0.305719055773751 3381 7566702
SGTC_3014 9081533 49.47 µM -0.510149775969703 0.343337694305864 no 2192 0.30497326759567 3400 21367265
SGTC_2629 bisabolol 100 µM -0.510266266077619 0.343301065327417 no 2193 0.304932466386691 3415 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1872 amphotericin b 148 nM -0.512551270280041 0.342582869950535 no 2194 0.304132623765729 3364 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1071 trifluoperazine 6.31 µM -0.512567743412544 0.34257769437295 no 2195 0.304126860907549 3429 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1277 0873-0036 22 µM -0.512750415218965 0.342520303984676 no 2196 0.304062959401165 3398 5965735
SGTC_2742 clothiapine 36.27 µM -0.513603721646445 0.342252267070812 no 2197 0.303764538529639 3352 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_521 r062-0005 13.8 µM -0.514963469169962 0.341825313291471 no 2198 0.303289273826349 3348 2832033
SGTC_145 3737-0113 38.366 µM -0.51674819676523 0.341265224910167 no 2199 0.302665973277688 3425 6849351
SGTC_2171 5739187 198.077 µM -0.51676033291289 0.341261417504177 no 2200 0.30266173679915 3227 2262761
SGTC_1757 st041620 31.8375 µM -0.518148030902202 0.340826169392637 no 2201 0.30217749540855 3369 5289815
SGTC_324 1315-0088 19.6 µM -0.518232484095179 0.340799687684864 no 2202 0.302148036441527 3374 6787421
SGTC_952 1185-0122 232 µM -0.520717586294352 0.340020794104031 no 2203 0.301281760768592 3352 678600
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.521497239215627 0.339776571707415 no 2204 0.301010214151003 3371 16486 A toxic proline analog.
SGTC_1659 st012954 42.1 µM -0.522165630051438 0.339567255132083 no 2205 0.300777507066147 3409 24207262
SGTC_1606 st000094 49.2 µM -0.523032523828593 0.339295848098888 no 2206 0.300475810127832 3443 1242210
SGTC_1683 st010134 710 nM -0.523117746014056 0.339269171241574 no 2207 0.300446158427788 3304 3818134
SGTC_2879 9041815 71.43 µM -0.523600727374603 0.339118000189589 no 2208 0.300278137746231 3362 4942971
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.523662607747786 0.339098633774667 no 2209 0.300256613727509 3375 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_836 0330-0104 1.35 µM -0.525252858644624 0.338601086264579 no 2210 0.299703711869967 3385 46494820
SGTC_1575 cyproterone acetate 48 µM -0.525586487496679 0.338496738310247 no 2211 0.299587773622408 3330 9880 An androgen receptor antagonist and liver toxin.
SGTC_325 2810-4341 181 µM -0.526057043213817 0.338349585286363 no 2212 0.299424286934288 3424 774970
SGTC_2158 5657123 3.6195 µM -0.526061412734127 0.338348218957812 no 2213 0.299422769007353 3376 2858827
SGTC_1789 tunicamycin 25 nM -0.526106878106286 0.338334002275014 no 2214 0.299406975006304 3420 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1971 st069429 63.5 µM -0.527007672702094 0.338052378061578 no 2215 0.299094130144568 3396 1246522 YGL099W LSG1
SGTC_191 3914-0123 66.505 µM -0.527834892550813 0.337793836041842 no 2216 0.298806968482379 3287 3144412
SGTC_2569 tetrandrine 100 µM -0.52965273554488 0.337225950366357 no 2217 0.298176361848968 3320 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1778 st046819 58.9 µM -0.530451800804016 0.3369764433028 no 2218 0.297899359395727 3341 671715
SGTC_8 0354-0001 70 µM -0.531714509703059 0.336582310358753 no 2219 0.297461870479013 3418 4993152
SGTC_2624 nerol 100 µM -0.534099417343852 0.335838392136073 no 2220 0.296636376426389 3379 637566 A natural product oil.
SGTC_265 mycophenolic acid 32.932 µM -0.535722229957831 0.335332559570302 no 2221 0.296075268820431 3525 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_752 1896-0090 130 µM -0.53573255166068 0.33532934323764 no 2222 0.296071701522955 3416 772567
SGTC_860 0443-0016 25.1 µM -0.537933728575398 0.334643713393544 no 2223 0.295311400931263 3410 5337942
SGTC_2811 7967822 32.47 µM -0.539071280083554 0.334289600899074 no 2224 0.294918835829974 3433 2232244
SGTC_231 b-estradiol 524 µM -0.539434087065863 0.334176692402384 no 2225 0.294793682991499 3311 450 A steroid.
SGTC_2260 7964312 200 µM -0.541325844803358 0.333588205219933 no 2226 0.294141504813897 3466 231951
SGTC_3164 9100705 49.47 µM -0.541481475735195 0.333539809815364 no 2227 0.294087881180788 3474 17174235
SGTC_31 0508-1974 57.237 µM -0.541703117695505 0.333470892229199 no 2228 0.294011520825935 3425 6810525
SGTC_821 1114-0266 29.2 µM -0.542367895177531 0.333264219330061 no 2229 0.293782545882595 3405 3123235
SGTC_2219 9098279 200 µM -0.543028307789522 0.333058953542887 no 2230 0.293555156100051 3428 902349
SGTC_2006 4011487 200 µM -0.543768480318748 0.332828956650704 no 2231 0.293300400704923 3481 45595294
SGTC_2358 9037157 4 µM -0.54415404141666 0.332709174551632 no 2232 0.293167737422587 3407 2388925
SGTC_2380 9035439 200 µM -0.545272059710174 0.332361936871625 no 2233 0.292783208774813 3496 6462575
SGTC_533 1222-0222 6.71 µM -0.545654706295875 0.332243126300751 no 2234 0.292651655997189 3486 3982874
SGTC_2954 9074818 52.69 µM -0.54628586811339 0.332047189367042 no 2235 0.292434724428163 3446 16648742
SGTC_2712 st079126 47.7 µM -0.54659421706621 0.331951482669002 no 2236 0.292328771469512 3371 3152970
SGTC_1339 1486-1321 22.7 µM -0.547865216425755 0.331557100114529 no 2237 0.291892227105672 3380 3469382
SGTC_1497 4476-2978 41.3 µM -0.548023318124748 0.331508055265784 no 2238 0.291837945875588 3447 1528379
SGTC_2909 7941780 10.49 µM -0.548262329746386 0.331433916773113 no 2239 0.291755894682021 3487 1243215
SGTC_402 epigallocatechin gallate 10 µM -0.552424836617789 0.330143819173082 no 2240 0.290328659062957 3363 65064 An antioxidant.
SGTC_1115 galangin 695.678 nM -0.553334261343551 0.329862226520687 no 2241 0.290017272292273 3509 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2793 7325131 81.82 µM -0.55452619741555 0.329493303532436 no 2242 0.289609390955212 3373 4176441
SGTC_2845 9003024 42.97 µM -0.555416492736808 0.329217851316414 no 2243 0.289304907096577 3534 2990173
SGTC_807 1315-0151 48 µM -0.555486720828676 0.32919612709342 no 2244 0.289280895266639 3528 4011080
SGTC_1285 0929-0069 65.5 µM -0.555753029254536 0.329113752997256 no 2245 0.289189849721734 3395 1206237
SGTC_644 1498-1197 63.3 µM -0.55619316788744 0.328977628208463 no 2246 0.289039404631282 3480 6741615
SGTC_395 anisomycin 6.25 µM -0.557096329609027 0.328698372022561 no 2247 0.288730807579536 3407 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2002 4023503 131 µM -0.55776694436882 0.328491080845858 no 2248 0.288501768811367 3538 4736863 YCR052W RSC6
SGTC_2438 5259590 200 µM -0.558521024936968 0.328258052910049 no 2249 0.288244325817311 3423 1201127
SGTC_3319 9138450 16.7555 µM -0.559303296895649 0.328016383798979 no 2250 0.287977372847251 3365 2029690
SGTC_443 clozapine 122 µM -0.560019985510372 0.327795038685445 no 2251 0.287732902913023 3407 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2656 pseudo-anisatin 100 µM -0.56022896247868 0.327730508750042 no 2252 0.287661637166485 3436 6708809 A neurotoxin.
SGTC_3213 9129884 49.47 µM -0.56157380220843 0.327315359239623 no 2253 0.287203216907377 3399 17190742
SGTC_286 k060-0067 22.9 µM -0.56463416012541 0.326371428835275 no 2254 0.286161312677762 3414 5985051
SGTC_42 0133-0086 60.653 µM -0.564842280808745 0.326307276802872 no 2255 0.286090522875355 3402 162923 Model of phenazepam hydroxylation.
SGTC_3166 9102297 49.47 µM -0.565859432950159 0.325993819316941 no 2256 0.285744670291903 3417 25237072
SGTC_11 0438-0307 1.3 µM -0.565914618661935 0.325976816157087 no 2257 0.285725911707567 3481 4011476
SGTC_1594 piperine 70.1 µM -0.566578892684605 0.325772176411441 no 2258 0.285500159378506 3445 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1970 st070122 35.8 µM -0.568235760125842 0.32526198194508 no 2259 0.284937446300788 3537 102928
SGTC_3279 9140807 49.47 µM -0.568441213088703 0.325198740194465 no 2260 0.28486770628522 3474 45595718
SGTC_139 0099-0334 718.624 µM -0.568643359997712 0.325136521014506 no 2261 0.284799096442438 3484 97690
SGTC_621 3584-0052 32.1 µM -0.568973229491903 0.325035000327914 no 2262 0.284687153742829 3493 2273927
SGTC_883 0850-0245 24.6 µM -0.569204229250065 0.324963915538867 no 2263 0.284608775440116 3513 6823229 YPR165W RHO1
SGTC_2964 9083345 53.42 µM -0.570537407050562 0.324553785729705 no 2264 0.284156629168568 3390 17741579
SGTC_1348 1493-0373 93.8 µM -0.570771402363295 0.324481822918884 no 2265 0.284077305280135 3423 3010129
SGTC_3156 9099931 49.47 µM -0.571231745545438 0.32434026831882 no 2266 0.283921280893194 3416 18111053
SGTC_305 1682-2595 20.8 µM -0.572713752940659 0.323884726505151 no 2267 0.28341926198327 3461 226033
SGTC_2398 5228213 48.84 µM -0.573639029176556 0.323600447254767 no 2268 0.283106047507638 3531 80771 YMR134W ERG29
SGTC_1453 4237-0541 195 µM -0.574241824053788 0.323415301613152 no 2269 0.28290208532072 3459 739892
SGTC_575 k072-0246 11.9 µM -0.574870555312735 0.32322223630933 no 2270 0.282689422488896 3481 6796779
SGTC_1376 2910-0861 41.3 µM -0.57548088730729 0.323034866422519 no 2271 0.282483056556513 3474 1112859
SGTC_1447 4239-0816 81.9 µM -0.576395392789533 0.322754200336294 no 2272 0.282173978907839 3411 1341554
SGTC_20 0481-0013 4.944 µM -0.57698684738019 0.322572733846453 no 2273 0.281974170280784 3463 182045
SGTC_184 1494-0393 24.714 µM -0.581567616992541 0.321168723774647 no 2274 0.280428980324804 3431 3090647
SGTC_863 0466-0191 129 µM -0.581794167027124 0.321099352059244 no 2275 0.280352666740609 3486 765160 YPR165W RHO1
SGTC_2079 5212404 121 µM -0.58387748537275 0.320461713651955 no 2276 0.27965137091219 3519 758462
SGTC_1224 0823-0416 294 µM -0.584915271016818 0.32014427750131 no 2277 0.279302344915812 3514 3598164
SGTC_482 fipronil 114 µM -0.584931767215981 0.320139232733262 no 2278 0.279296798656483 3522 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_3065 9113888 49.47 µM -0.58544705702384 0.319981666659919 no 2279 0.279123577764625 3562 16648368
SGTC_1198 1612-1005 86.7 µM -0.586279435759595 0.319727209263017 no 2280 0.278843873981831 3573 6998509
SGTC_2715 st079500 56.4 µM -0.586451689848394 0.319674561939459 no 2281 0.278786008570105 3459 28246688
SGTC_1728 st035614 33.7865 µM -0.587556863231325 0.319336865892987 no 2282 0.278414886168234 3427 15945546
SGTC_917 harmaline 728.087 nM -0.588581360488612 0.319023954981153 no 2283 0.278071070354574 3452 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_715 0868-0130 184 µM -0.591088398360025 0.31825877765024 no 2284 0.277230596447498 3571 2876258
SGTC_1081 sertraline 6 µM -0.592879509900997 0.317712583714307 no 2285 0.276630895831281 3515 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3092 9117248 49.47 µM -0.594800094939331 0.31712734769765 no 2286 0.275988552054705 3523 17141857
SGTC_379 3970-0972 5.9 µM -0.595541923239152 0.316901421863915 no 2287 0.27574064224698 3484 2898042 YBL034C STU1
SGTC_602 3130-1533 38.1 µM -0.595809455911059 0.316819960800698 no 2288 0.275651263010761 3541 720941
SGTC_1672 st016598 6.51 µM -0.595960323802119 0.316774026929766 no 2289 0.275600866263958 3442 4665860 YNL267W PIK1
SGTC_3044 9093193 49.47 µM -0.597608615388613 0.316272365297499 no 2290 0.275050557136255 3493 25236277
SGTC_3171 9103192 49.47 µM -0.597942068362359 0.316170919130213 no 2291 0.274939294262745 3561 13018434
SGTC_270 tamoxifen 5.46 µM -0.598796270217117 0.315911109028405 no 2292 0.274654374916198 3611 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2869 9037858 32.47 µM -0.599671637138283 0.315644955770486 no 2293 0.274362547111715 3499 27187042
SGTC_500 h-89 112 µM -0.6004079321837 0.31542116099474 no 2294 0.274117201348004 3567 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1260 0700-1617 7.75 µM -0.602152428868266 0.314891196519124 no 2295 0.273536338993049 3515 2853078
SGTC_69 0096-0274 206.684 µM -0.602979464644436 0.31464008254188 no 2296 0.273261175196871 3663 6741392
SGTC_3322 9139058 2.11 µM -0.604569406529731 0.314157567202286 no 2297 0.272732569721828 3551 4908926 YPR165W RHO1
SGTC_1519 esterone 74 µM -0.605101504050553 0.313996157180599 no 2298 0.27255577747832 3449 698 A steroid.
SGTC_2181 6316240 54.2555 µM -0.605468285155931 0.313884916059473 no 2299 0.272433945631599 3508 12779990
SGTC_781 4335-2806 94.4 µM -0.605598484710708 0.313845431875349 no 2300 0.272390704401677 3572 845254
SGTC_2197 6588183 93.1375 µM -0.607015524747792 0.31341583968756 no 2301 0.27192030467478 3507 884136
SGTC_1801 st050089 28.441 µM -0.607228183703132 0.31335139146854 no 2302 0.271849745428722 3528 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_153 4077-0274 519.67 µM -0.607970400927495 0.313126500496252 no 2303 0.271603552631423 3635 3121976
SGTC_1306 1185-0270 9.02 µM -0.608788569680183 0.312878676823356 no 2304 0.271332295481244 3535 1548076
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.60980603850831 0.312570603012196 no 2305 0.27099515047669 3503 15053
SGTC_271 rotenone 740 µM -0.61065330252118 0.312314164472313 no 2306 0.270714563523008 3568 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2856 9022925 19.48 µM -0.61102425393844 0.312201918457452 no 2307 0.270591761859764 3514 4944862
SGTC_480 am 92016 50 µM -0.611226037580896 0.312140868158484 no 2308 0.27052497405234 3475 2129 K+ channel blocker.
SGTC_2092 5303694 80.6725 µM -0.612934800413152 0.31162408333885 no 2309 0.269959725772033 3502 1963699
SGTC_3339 9145883 14.936 µM -0.616763817410836 0.310467413025131 no 2310 0.268695260450388 3506 2030670
SGTC_1607 st000305 50.6 µM -0.616835010635127 0.310445924649281 no 2311 0.26867177835206 3542 5457690
SGTC_154 3389-1638 511.116 µM -0.61739461542587 0.310277040685107 no 2312 0.268487236382251 3468 5238686
SGTC_1090 efavirenz 20.7 µM -0.617648097310198 0.310200555170022 no 2313 0.268403666139346 3555 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1368 1852-0141 284 µM -0.617661824202158 0.31019641345783 no 2314 0.268399140904538 3525 2838987
SGTC_1946 st076057 65.1 µM -0.618066761200345 0.310074245686004 no 2315 0.268265665821642 3467 953009
SGTC_1926 methyl fluorone black 53.6 µM -0.618600431197698 0.309913271734838 no 2316 0.268089808867006 3432 72721 Reacts with homocysteine.
SGTC_3336 9143619 71.43 µM -0.619240674258271 0.309720199614463 no 2317 0.267878910147191 3583 45595730
SGTC_737 1950-0117 57.9 µM -0.622325981752884 0.308790528868166 no 2318 0.266863770101176 3532 5393513
SGTC_706 4262-0057 46.9 µM -0.623772284692859 0.308355147056606 no 2319 0.26638857180379 3531 883298
SGTC_2446 5162541 200 µM -0.624648903622451 0.30809138880097 no 2320 0.266100757815808 3519 1549321
SGTC_953 1188-0045 9.7 µM -0.625723155738471 0.307768301523435 no 2321 0.265748271202863 3555 6144426
SGTC_2069 5228469 200 µM -0.628689835205884 0.306876830719672 no 2322 0.264776067034401 3531 2835210
SGTC_3151 9099821 49.47 µM -0.630156326424354 0.306436579188913 no 2323 0.264296155105473 3537 17174189
SGTC_1753 st043925 64 µM -0.632409590350696 0.305760676937411 no 2324 0.263559634413326 3562 670181
SGTC_1265 0819-1001 68.8 µM -0.634172325747651 0.30523237725109 no 2325 0.262984183025691 3581 3106768
SGTC_1018 4259-0013 28.1 µM -0.634479160086123 0.305140459031769 no 2326 0.262884081504969 3562 6801262
SGTC_1169 aniline yellow 25.8 µM -0.635922145828949 0.30470834934264 no 2327 0.26241358376348 3531 6051 A DNA damaging agent.
SGTC_287 k060-0039 29.6 µM -0.638067884180797 0.304066300313072 no 2328 0.261714745718324 3601 5861974
SGTC_2936 9038235 15.59 µM -0.639004060566729 0.303786366144594 no 2329 0.261410145165191 3583 4749415
SGTC_1399 3562-5772 25 µM -0.639739220014525 0.303566620419196 no 2330 0.261171076498801 3535 23847490
SGTC_3204 9114183 49.47 µM -0.641810783103371 0.302947793868854 no 2331 0.260498023701807 3589 17027248
SGTC_2828 7998861 71.43 µM -0.642105520225014 0.302859794582122 no 2332 0.260402335962301 3518 2988188
SGTC_1813 st051246 8.6015 µM -0.643241650120902 0.302520688864218 no 2333 0.2600336557244 3553 5291959
SGTC_497 capsazepine 133 µM -0.643447436593255 0.302459285076455 no 2334 0.259966905713922 3534 2733484 A calcium channel blocker.
SGTC_318 1488-0629 67.2 µM -0.643730275182166 0.302374899141385 no 2335 0.259875177084786 3584 3662576
SGTC_3123 9126162 49.47 µM -0.643754556565855 0.302367655193317 no 2336 0.259867303060544 3630 25239884
SGTC_136 0097-0015 404.482 µM -0.644660994739451 0.302097290110683 no 2337 0.25957344923781 3614 4861337
SGTC_1949 st076024 69.1 µM -0.645425439812206 0.301869361993679 no 2338 0.259325760900363 3565 2921930
SGTC_2506 ethyl hematommate 54.16 µM -0.646044217470794 0.301684922908693 no 2339 0.259125359824722 3551 3940691 An allergen.
SGTC_801 0866-0028 10.1 µM -0.646050484690067 0.301683055097603 no 2340 0.25912333049483 3627 6849771
SGTC_2939 9044578 71.43 µM -0.646171185201613 0.301647083897925 no 2341 0.259084249189536 3565 2653634
SGTC_4 0960-0234 25.671 µM -0.646380847167301 0.301584604967076 no 2342 0.259016370531688 3589 6821112
SGTC_2162 5663267 200 µM -0.648342672395303 0.3010002664943 no 2343 0.258381669985226 3596 6456493
SGTC_2665 lovastatin 100 µM -0.649260883860916 0.300726948540474 no 2344 0.25808488221898 3596 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1578 josamycin 24.2 µM -0.649988499180083 0.300510443656053 no 2345 0.257849825266695 3524 5282165 A P450 substrate.
SGTC_2645 abamectin 100 µM -0.650281992465434 0.300423133469021 no 2346 0.257755043381463 3587 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_216 k038-0035 28.382 µM -0.650440351558305 0.300376028592841 no 2347 0.257703909780556 3543 4444231 YPR107C YTH1
SGTC_2027 5150920 200 µM -0.65177295061682 0.299979771165417 no 2348 0.257273826879934 3588 786715
SGTC_390 dec-rvkr-cmk 16.7 µM -0.652486905290721 0.299767569229751 no 2349 0.257043558796222 3639 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1579 chlormadinone acetate 49.4 µM -0.65334774970558 0.299511799092889 no 2350 0.256766057746469 3614 45114258 A steroidal progestin.
SGTC_469 w7 172 µM -0.654342086147259 0.299216489599599 no 2351 0.256445718532896 3625 45115570 A P450 inhibitor.
SGTC_1275 0867-0008 21.1 µM -0.655219729295353 0.298955946852049 no 2352 0.256163146782039 3565 3422836
SGTC_518 1021-0119 62.6 µM -0.656606715924644 0.298544407385375 no 2353 0.255716914725177 3531 1097762
SGTC_1767 st044992 70.3 µM -0.65671579517658 0.298512052889381 no 2354 0.255681838127885 3568 9600693
SGTC_39 0986-0283 58.349 µM -0.657938320180038 0.298149543332641 no 2355 0.255288882902557 3645 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1470 k295-0292 231 µM -0.658501145650606 0.297982718798155 no 2356 0.255108080555026 3628 5045612
SGTC_2317 5986382 200 µM -0.660191469050968 0.297481953692722 no 2357 0.254565483065338 3651 877883
SGTC_1416 3966-0321 25.3 µM -0.661229843434777 0.29717452176784 no 2358 0.254232462637624 3620 582530 YLR208W SEC13
SGTC_1925 st057770 10.1 µM -0.661936743394947 0.296965312738604 no 2359 0.254005881209846 3546 5989122
SGTC_1638 st008370 60.6 µM -0.662142147003365 0.296904535599364 no 2360 0.253940063416497 3615 24207134
SGTC_2480 5767542 37.17 µM -0.662952979724108 0.296664672856228 no 2361 0.25368033446722 3623 2867358
SGTC_2184 6075246 200 µM -0.663008380728195 0.296648287219799 no 2362 0.253662593304918 3621 2267320
SGTC_1301 naphtanilide LB 4.81 µM -0.665076233373114 0.296036987037858 no 2363 0.2530008675169 3660 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2367 9070478 135.38 µM -0.667061800896405 0.295450556784174 no 2364 0.252366329332395 3601 572802
SGTC_1871 st057448 67.3 µM -0.668343159444185 0.295072396029567 no 2365 0.25195728469524 3710 691747
SGTC_669 0108-0021 26.2 µM -0.668532464364789 0.295016546348408 no 2366 0.251896883072971 3719 17201
SGTC_936 3005-4620 401 µM -0.668589422627629 0.294999743190907 no 2367 0.251878710865446 3642 777207
SGTC_1001 4048-4355 44.4 µM -0.668802884111797 0.294936774214686 no 2368 0.251810613358256 3621 21824233
SGTC_1982 st072467 71.9 µM -0.669199761592269 0.294819715842735 no 2369 0.251684029158455 3602 3163533
SGTC_1269 0831-0796 3.05 µM -0.671748861728533 0.294068373950617 no 2370 0.250871794647879 3624 927758
SGTC_1236 0330-0013 258 µM -0.673493742357117 0.293554584868432 no 2371 0.250316614243447 3623 4617066
SGTC_1193 1488-0126 41.5 µM -0.67382769265675 0.293456298894617 no 2372 0.250210433341513 3658 1384710
SGTC_2716 st080858 38.6235 µM -0.673836111082779 0.293453821437889 no 2373 0.250207756976249 3618 5296050
SGTC_1495 4469-0029 237 µM -0.673966317985424 0.293415504111266 no 2374 0.250166363851962 3639 793680
SGTC_2842 9000675 19.48 µM -0.674081024898914 0.293381750046707 no 2375 0.250129901225315 3598 2989072
SGTC_1655 st012546 55.1 µM -0.674490759476595 0.293261194785562 no 2376 0.249999679274407 3603 720985 YLR208W SEC13
SGTC_1736 st036774 51 µM -0.675358830702106 0.293005860076764 no 2377 0.249723907538828 3667 1272247
SGTC_2699 st077704 54.6 µM -0.676769793704464 0.292591059249743 no 2378 0.249276013055995 3640 645852
SGTC_3321 9137793 26.8275 µM -0.677729119035131 0.292309188670253 no 2379 0.248971730025451 3628 4904192
SGTC_2479 5617353 43.85 µM -0.682538431770914 0.290898015537082 no 2380 0.247449275024433 3681 2731746
SGTC_2754 granisetron 64.02 µM -0.682560068614103 0.290891673944746 no 2381 0.247442436839798 3647 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1425 4048-4433 7.33 µM -0.684098403630941 0.290440965482235 no 2382 0.246956514923761 3704 23734946
SGTC_2275 7947463 200 µM -0.685306780234034 0.290087159156826 no 2383 0.246575177083445 3609 1225414
SGTC_281 1672-3440 14.9 µM -0.685395963432489 0.290061054790963 no 2384 0.246547045275854 3654 6833000
SGTC_1097 itavastatin 7.23 µM -0.68547254742136 0.290038639155202 no 2385 0.246522889115378 3676 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1437 4092-1038 11.6 µM -0.686011085160672 0.289881035595882 no 2386 0.246353059084673 3652 3977136
SGTC_2673 kobusone 100 µM -0.688491575827945 0.289155636827298 no 2387 0.245571636718687 3714 6710676 An epoxy ketone and protein crosslinker.
SGTC_1502 4534-4282 27.7 µM -0.690403702695844 0.288597034521858 no 2388 0.244970174447961 3642 3278949
SGTC_1245 0418-0076 17.2 µM -0.694253461540099 0.28747392366807 no 2389 0.243761635413055 3671 6790114
SGTC_2293 7624732 200 µM -0.695273442618007 0.287176705827731 no 2390 0.243441977094049 3636 894453
SGTC_3139 9095020 49.47 µM -0.696430245026726 0.286839795021462 no 2391 0.243079713728158 3477 25236292
SGTC_2190 6049624 200 µM -0.697596462767692 0.286500331793968 no 2392 0.242714797169438 3599 2265554
SGTC_1423 4048-0112 5.59 µM -0.697898339743391 0.286412492362737 no 2393 0.242620386384296 3669 X1423
SGTC_3144 9087057 49.47 µM -0.698668115257896 0.286188562817616 no 2394 0.242379732279198 3599 17249618
SGTC_2649 anisomycin 9.56 µM -0.701926366128995 0.285241651870485 no 2395 0.241362542570221 3657 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_396 dithiazanine 1.25 µM -0.701971861084732 0.28522844072765 no 2396 0.241348355987423 3666 10578 An antihelmenthic.
SGTC_729 4092-0585 94.1 µM -0.703457898648994 0.284797075146159 no 2397 0.24088521763686 3674 2169061
SGTC_2471 5466956 24.79 µM -0.704025384936042 0.284632427941084 no 2398 0.240708482555464 3653 724419
SGTC_2 0422-0095 29 µM -0.704980503261747 0.284355418065023 no 2399 0.240411184710111 3578 6790840
SGTC_3174 9107204 49.47 µM -0.705608671189492 0.284173302812813 no 2400 0.240215765164614 3698 3938802
SGTC_319 1348-1596 45.5 µM -0.706137657702621 0.28401998500424 no 2401 0.240051267572037 3746 5380505
SGTC_3247 9135149 49.47 µM -0.706907228846079 0.283797008493958 no 2402 0.239812065693335 3657 8934436 YOR116C RPO31
SGTC_2244 6635614 200 µM -0.710375400500424 0.282793177398509 no 2403 0.238735686817125 3612 836499
SGTC_837 0091-0265 12.5 µM -0.71043266157457 0.282776618018872 no 2404 0.238717937525944 3677 759367
SGTC_919 tnp00227 403.569 nM -0.710813582074041 0.282666471148008 no 2405 0.238599881472163 3701 1269246 A methoxyflavone. YNL221C POP1
SGTC_2200 6600604 21.907 µM -0.711702362710572 0.282409551783379 no 2406 0.238324552140484 3654 2904777
SGTC_594 1487-1584 10.8 µM -0.713989527344067 0.281748919174449 no 2407 0.237616827659351 3680 5013332
SGTC_824 1304-0008 100 µM -0.714605828753144 0.281571032020914 no 2408 0.237426321025576 3714 768245
SGTC_1511 0906-3109 28.5 µM -0.714850611980652 0.2815003936518 no 2409 0.237350678677637 3748 2882180
SGTC_2316 5844804 197.44 µM -0.71553916675411 0.281301739679147 no 2410 0.237137974053526 3757 776813
SGTC_146 3448-8650 53.125 µM -0.715892995299841 0.281199683431646 no 2411 0.237028711998471 3700 2891488 YIL048W NEO1
SGTC_1048 3161-0300 24.5 µM -0.716007874648715 0.28116655214594 no 2412 0.236993243271024 3708 2165101
SGTC_2228 7354201 200 µM -0.716658748811248 0.280978875183566 no 2413 0.236792342506711 3722 753451
SGTC_17 0960-0276 49.807 µM -0.717221270272365 0.280816723154685 no 2414 0.236618788425481 3694 6821114
SGTC_2650 prasterone 100 µM -0.718870482177429 0.280341583478215 no 2415 0.236110362622561 3666 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1199 1638-0010 4.46 µM -0.720204427716128 0.279957557386173 no 2416 0.235699569080891 3693 3111136
SGTC_531 3788-1495 174 µM -0.720243075590602 0.279946434953839 no 2417 0.235687673200913 3678 2896655
SGTC_3349 9149703 23.001 µM -0.720251321382644 0.279944061933501 no 2418 0.235685135175282 3693 4910494
SGTC_2100 5377183 190 µM -0.721311382098637 0.2796390729633 no 2419 0.23535897779369 3743 2844202
SGTC_1690 st023502 41.2 µM -0.721644403440975 0.279543293039982 no 2420 0.235256565898611 3691 24207482
SGTC_2080 5212524 12.4 µM -0.723987008090742 0.278869989414796 no 2421 0.234536855596503 3680 260183
SGTC_2944 9067346 25.62 µM -0.725272340740748 0.278500898944953 no 2422 0.234142485347228 3654 6473075
SGTC_906 1165-0455 526 µM -0.726524292955438 0.278141622796361 no 2423 0.233758710273125 3695 3252859
SGTC_603 3794-0023 45.9 µM -0.727391174008338 0.277892984095456 no 2424 0.233493179841976 3713 3802260
SGTC_1340 1486-1359 257 µM -0.72817533040986 0.277668165964154 no 2425 0.233253132607129 3678 4309068
SGTC_2982 9019404 25.97 µM -0.731695759762061 0.276659952818424 no 2426 0.232177142537445 3630 22333232
SGTC_1468 k284-1086 134 µM -0.733159346358109 0.276241325941102 no 2427 0.231730623676994 3729 15996457
SGTC_2401 5128683 200 µM -0.733186269318579 0.276233628130664 no 2428 0.231722414359776 3697 708373
SGTC_3330 9141424 71.43 µM -0.735417485595058 0.27559604507539 no 2429 0.231042637988151 3767 27261020
SGTC_548 1436-0017 110 µM -0.735965541573273 0.275439545660582 no 2430 0.230875834251572 3769 9677137
SGTC_366 0181-0206 4.31 µM -0.736312194601563 0.275340580182037 no 2431 0.230770363296338 3728 274874
SGTC_2738 aclarubicin 5.55 µM -0.736944766791643 0.275160033162905 no 2432 0.230577969354869 3668 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.737988863959794 0.2748621573891 no 2433 0.230260608131434 3729 688667
SGTC_2512 diallyl trisulfide 49.23 µM -0.742489889740324 0.273579859236835 no 2434 0.228895287576677 3764 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2297 7971671 152.32 µM -0.745525043245911 0.272716848147118 no 2435 0.227977188766679 3729 909016
SGTC_754 3474-0146 171 µM -0.745612012952423 0.272692139231109 no 2436 0.227950912001154 3708 24762078
SGTC_1051 3253-3903 78 µM -0.745924952821095 0.272603239246983 no 2437 0.227856375387156 3751 5509239
SGTC_2744 captopril 92.04 µM -0.746530665276139 0.272431209283117 no 2438 0.227673457222463 3697 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2132 5317594 122.667 µM -0.748610900724845 0.271840807092267 no 2439 0.227045880009339 3727 794577
SGTC_1953 st076800 12.1 µM -0.749178047461772 0.271679952811685 no 2440 0.226874949335222 3783 297591
SGTC_2575 plumbagin 510 nM -0.750298507864007 0.271362306926133 no 2441 0.226537470548346 3706 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1781 st038725 66.3 µM -0.752412758818084 0.270763430051744 no 2442 0.225901438080738 3776 4270275 YIL048W NEO1
SGTC_2103 5378138 10 µM -0.75324173183472 0.27052879765431 no 2443 0.225652333047178 3794 244142
SGTC_3252 9135871 49.47 µM -0.753722205976299 0.270392850841263 no 2444 0.225508022531735 3770 17682838
SGTC_1430 4049-0248 69.1 µM -0.755015635002536 0.270027053866145 no 2445 0.225119800534733 3777 22774488
SGTC_1820 st053765 18.6 µM -0.755133553053503 0.269993717571679 no 2446 0.225084426341656 3756 3690829
SGTC_1644 st010134 20.9 µM -0.755146039757155 0.269990187609928 no 2447 0.225080680644407 3756 3818134
SGTC_1129 3453-1384 223 µM -0.759238801031361 0.26883441950083 no 2448 0.223854859601389 3902 1084452
SGTC_2199 6590217 200 µM -0.760136294764499 0.268581305922023 no 2449 0.223586559803227 3701 703109
SGTC_2161 5662504 8.5105 µM -0.760904720222075 0.268364687740867 no 2450 0.223356989504246 3766 2859334
SGTC_257 daunorubicin 18.5 µM -0.762043383621902 0.26804386159472 no 2451 0.223017055846105 3806 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1969 st069479 40.1 µM -0.763599383761551 0.26760576041824 no 2452 0.222553008313752 3756 3895485
SGTC_1116 jasmonic acid 1.58368 µM -0.763914062463291 0.267517204642682 no 2453 0.222459228331649 3795 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2893 9048488 25.97 µM -0.764551484307014 0.26733786891778 no 2454 0.222269334095518 3779 6467338
SGTC_1885 st057546 99.9 µM -0.765298277757037 0.267127839175496 no 2455 0.222046974680065 3849 702008
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.765828359578714 0.266978808427307 no 2456 0.221889218726746 3731 279621
SGTC_2865 9030313 51.95 µM -0.766203998707584 0.266873224159501 no 2457 0.221777464730898 3722 42562754
SGTC_2766 oltipraz 83.91 µM -0.766307722223264 0.266844073375534 no 2458 0.221746612276671 3744 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_354 2783-3500 4.88 µM -0.769440620503267 0.265964352625331 no 2459 0.220815891094258 3800 6740761
SGTC_605 1315-0399 119 µM -0.769534673846075 0.265937965094245 no 2460 0.220787984362397 3873 24020461
SGTC_219 mitoxanthrone 164.414 µM -0.770960179845337 0.26553818873599 no 2461 0.220365267330465 3771 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_693 4161-2696 114 µM -0.771445600075969 0.265402124561175 no 2462 0.220221427630508 3836 805759
SGTC_296 1222-0039 74.9 µM -0.772538306725474 0.265095966417359 no 2463 0.219897833929191 3766 5984176
SGTC_2424 5537928 59.2 µM -0.774314955968565 0.26459856223557 no 2464 0.219372280710086 3860 5382802
SGTC_3273 9137859 49.47 µM -0.77447987257467 0.264552415025087 no 2465 0.219323533122182 3854 2377234
SGTC_2023 5144124 124 µM -0.774782952189727 0.264467617514321 no 2466 0.219233962258973 3791 2830192
SGTC_3071 9117417 49.47 µM -0.77729415993863 0.263765548608724 no 2467 0.218492619906087 3735 45595590 YGL055W OLE1
SGTC_2155 5570423 76 µM -0.779216345454383 0.263228798058269 no 2468 0.21792614153829 3752 797402
SGTC_977 1348-1378 135 µM -0.779288561068943 0.263208643469556 no 2469 0.217904875729446 3790 X977
SGTC_3190 9110366 49.47 µM -0.780239919678288 0.262943203296054 no 2470 0.217624834624777 3743 17123768
SGTC_1333 1482-0047 286 µM -0.780490689858815 0.26287325828153 no 2471 0.217551052730567 3760 3811116
SGTC_3342 9147791 14.508 µM -0.781558772913182 0.262575454314049 no 2472 0.217236961836523 3746 1838168
SGTC_643 k048-0106 28.4 µM -0.782045945227143 0.262439677811463 no 2473 0.217093786231137 3830 6763920
SGTC_2787 5284540 71.43 µM -0.785789334617403 0.261397583688594 no 2474 0.215995457967197 3851 736958
SGTC_1105 epirubicin 18.1 µM -0.787868085273823 0.260819814959287 no 2475 0.215386935377631 3812 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1676 st018489 23.4 µM -0.788162168339189 0.260738130480406 no 2476 0.215300927421246 3866 3696235
SGTC_642 0335-0876 158 µM -0.790080529779889 0.260205609818958 no 2477 0.214740369911549 3837 6812350
SGTC_1196 1588-0294 184 µM -0.790702157785733 0.260033171544989 no 2478 0.214558908309009 3836 6144269
SGTC_1079 idarubicin 2.36 µM -0.791124494552776 0.259916049857717 no 2479 0.214435673378076 3768 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2769 toremifene 3.73 µM -0.791758255865676 0.25974034735489 no 2480 0.214250823478738 3818 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1931 st074438 57.1 µM -0.791814496890978 0.259724758186353 no 2481 0.214234424072782 3789 2787313
SGTC_3246 9135460 32.98 µM -0.791888875224826 0.259704142369569 no 2482 0.214212737103027 3735 41446951
SGTC_2001 4023502 57.655 µM -0.792124929817265 0.259638719525464 no 2483 0.214143917605349 3844 108941 YCR052W RSC6
SGTC_666 0272-0154 136 µM -0.793608909674781 0.259227627486211 no 2484 0.21371157198865 3851 6870312
SGTC_2101 5377231 179.231 µM -0.794439669026589 0.258997637532853 no 2485 0.213469759077107 3867 2844213
SGTC_2781 5567276 71.43 µM -0.798528592038676 0.257867187557688 no 2486 0.212281903862661 3873 2853274
SGTC_479 n-linoleoylglycine 10 µM -0.799673896185082 0.257551009026938 no 2487 0.211949880426047 3859 6433346 An anti-infammatory.
SGTC_1085 doxorubicin 7.67 µM -0.799797172707326 0.257516988685163 no 2488 0.211914160703647 3826 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_626 0214-0009 33 µM -0.801668516964898 0.257000844861498 no 2489 0.211372365988176 3890 3437874
SGTC_3264 9137442 49.47 µM -0.802786915343058 0.256692631525403 no 2490 0.211048953126907 3804 17015726
SGTC_650 1328-0195 38 µM -0.805356904578528 0.255985112068506 no 2491 0.210306876476199 3766 2780821
SGTC_2119 5528445 120.635 µM -0.805888321718381 0.25583893968148 no 2492 0.210153622755643 3852 791935
SGTC_1967 st070177 51.4 µM -0.80602063714194 0.255802551579847 no 2493 0.210115474928534 3883 5729214
SGTC_322 k048-0136 19.3 µM -0.806360278040862 0.255709159210472 no 2494 0.210017571769403 3888 6823282
SGTC_1263 0774-1208 64.8 µM -0.806942178890641 0.255549193077188 no 2495 0.209849898303672 3834 906585
SGTC_2524 avocatin b 10.57 µM -0.808087156846419 0.255234588200229 no 2496 0.209520205230099 3816 6710748
SGTC_2404 5161160 200 µM -0.810534199514753 0.254562895301732 no 2497 0.208816608761296 3803 2831543
SGTC_1581 himbacine 57.9 µM -0.813341050913644 0.253793579664905 no 2498 0.208011273522208 3849 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1734 st037168 69.4 µM -0.813710223993898 0.253692485795756 no 2499 0.207905487851816 3923 708907
SGTC_1185 1319-0113 81.3 µM -0.813829807537616 0.253659743730983 no 2500 0.207871228283758 3906 4672763
SGTC_664 1222-0054 14.9 µM -0.814037845284951 0.253602788127691 no 2501 0.207811635358095 3809 6813991
SGTC_734 2023-0417 80 µM -0.816805297783954 0.252845767418249 no 2502 0.207019852099658 3863 3935732
SGTC_2229 7354935 190 µM -0.817363735122917 0.252693154462351 no 2503 0.206860296838694 3784 318112
SGTC_1457 k015-0032 57.3 µM -0.818277056134868 0.252443661450348 no 2504 0.206599502068845 3860 4302660
SGTC_419 nsc-638432 893 µM -0.818815562574486 0.252296617851305 no 2505 0.20644582523938 3828 368090
SGTC_844 0330-0132 15.3 µM -0.819795966364155 0.252029026545892 no 2506 0.206166215455305 3889 2828079
SGTC_2019 4016004 108 µM -0.819808768013651 0.252025533455745 no 2507 0.206162565928431 3885 45595336
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.82149737520358 0.25156499986819 no 2508 0.205681509289235 3889 616764
SGTC_3295 9122362 53.5725 µM -0.821999982750935 0.251428009697801 no 2509 0.205538453361148 3915 4730473
SGTC_1539 benzyladenosine 56 µM -0.822520764783019 0.251286107511014 no 2510 0.205390286809251 3841 92208 A nucleotide analog.
SGTC_1270 0831-1170 17.3 µM -0.824740910178028 0.250681639788929 no 2511 0.204759350142102 3867 6764716
SGTC_2303 7774051 200 µM -0.82494750465124 0.250625430550564 no 2512 0.204700697343665 3818 2953184
SGTC_1250 0485-0349 40.2 µM -0.825186829204394 0.250560324615674 no 2513 0.204632764872219 3881 6842794 YDL195W SEC31
SGTC_3261 9137475 49.47 µM -0.826175910498097 0.250291349662259 no 2514 0.204352155626291 3764 17027690
SGTC_57 miconazole 162.5 nM -0.826189744565349 0.250287588653364 no 2515 0.204348232430298 3820 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3254 9136651 49.47 µM -0.826474672299967 0.250210133229203 no 2516 0.204267439893755 3857 16454030
SGTC_3052 9092717 49.47 µM -0.827808530435484 0.249847703213514 no 2517 0.203889471452021 3864 25237534
SGTC_420 mitomycin C 81.9 mM -0.827858289344434 0.249834188337686 no 2518 0.203875379597859 3849 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1879 gemcitabine 100 µM -0.829993199015577 0.249254697315412 no 2519 0.203271314434264 3863 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3303 9125618 40.5795 µM -0.830583791195545 0.249094515723819 no 2520 0.203104397264802 3918 22695467
SGTC_2255 7941087 197.44 µM -0.830780864179397 0.249041077382982 no 2521 0.203048717374935 3899 935561
SGTC_996 3970-0799 1.8 µM -0.830976759769376 0.248987964349996 no 2522 0.202993379173182 3911 6615648 YGL040C HEM2
SGTC_1987 st072290 61.9 µM -0.831213093665529 0.248923895330957 no 2523 0.202926629613763 3900 54697379
SGTC_1429 4049-0205 9.46 µM -0.832394727234479 0.248603691622075 no 2524 0.202593088640321 3889 22774478
SGTC_771 0250-0039 27.3 µM -0.832614706923259 0.248544104896579 no 2525 0.20253103093814 3852 3005115
SGTC_1878 temozolomide 1 mM -0.835593771815736 0.247737904221932 no 2526 0.201691736865332 3787 5394 DNA alkylating agent.
SGTC_1219 1469-0211 33.1 µM -0.835966525930733 0.247637127118299 no 2527 0.201586867416766 3891 6822282
SGTC_1384 3089-0840 101 µM -0.836166821695574 0.247582984576195 no 2528 0.201530530342951 3836 1069836
SGTC_135 0933-0004 26.348 µM -0.840909497968535 0.246302827325388 no 2529 0.200199318540918 3885 21230617 YGL099W LSG1
SGTC_574 1315-0397 40 µM -0.840917966588677 0.246300544628373 no 2530 0.200196946238191 3892 6794277
SGTC_1405 3909-7894 12 µM -0.842575106214183 0.245854084788083 no 2531 0.199733059188322 3910 7104060
SGTC_916 4466-0038 42 nM -0.843931227379971 0.245489047555799 no 2532 0.199353918512393 3982 5722064 YGL116W CDC20
SGTC_162 k030-0015 37.8 µM -0.845032262823396 0.245192887973135 no 2533 0.199046412982143 3962 1809920 YMR134W ERG29
SGTC_2795 7780010 54.55 µM -0.84538478276938 0.245098106793724 no 2534 0.198948018970314 3911 953673
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.847110921603697 0.244634288668076 no 2535 0.198466649057846 3891 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_460 trequinsin 123 µM -0.847118496465334 0.244632254324681 no 2536 0.198464538199028 3938 5537 A vasodilator.
SGTC_1833 st055984 71 µM -0.847273578265882 0.244590606769671 no 2537 0.198421325101759 3924 676288
SGTC_3093 9117344 49.47 µM -0.84833425067699 0.244305863289956 no 2538 0.198125924014416 3950 24824913
SGTC_2055 5235184 200 µM -0.848853620927019 0.244166500615315 no 2539 0.197981374421864 3951 2836034
SGTC_65 0798-0905 34.986 µM -0.850725249105779 0.243664642199013 no 2540 0.197460996979403 3949 3602145
SGTC_809 3998-0021 90 µM -0.850853797930829 0.243630193566927 no 2541 0.197425286333332 3871 715485
SGTC_2251 lansoprazole 556 µM -0.851465201571074 0.243466385064847 no 2542 0.197255492903615 3818 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_221 trifluoperazine 10.304 µM -0.851749185810885 0.243390319673666 no 2543 0.197176657450942 3873 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2772 vinpocetine 57.06 µM -0.852180524937751 0.243274809734598 no 2544 0.197056952014919 3891 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1520 flindersine 88 µM -0.853737300551172 0.242858161464705 no 2545 0.196625280881707 4049 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_175 3793-3120 23.7 µM -0.853835532995408 0.242831883942257 no 2546 0.196598061687492 3915 5322297
SGTC_2810 7959871 45.46 µM -0.854242957620492 0.242722912856784 no 2547 0.19648519290861 3902 2974535
SGTC_647 0140-0236 81 µM -0.85510282291403 0.242493017464412 no 2548 0.196247113486256 3920 990837
SGTC_2050 5263056 171 µM -0.857007069444418 0.241984314200281 no 2549 0.195720488824399 3950 763468 YGL055W OLE1
SGTC_703 3875-0075 71.8 µM -0.858255822324245 0.241651034995069 no 2550 0.195375608925512 3936 2850814
SGTC_2654 protoveratrine a 100 µM -0.858884649674168 0.241483301874708 no 2551 0.19520207957141 3903 5702278 A heart drug and vasodilator.
SGTC_2306 7482397 179.52 µM -0.859670916269752 0.241273662476198 no 2552 0.194985235567084 3914 891448
SGTC_2913 7966556 36.57 µM -0.860846491523814 0.240960407694916 no 2553 0.194661297671309 3784 2976516
SGTC_2342 7990637 118.86 µM -0.860926967071329 0.240938971520252 no 2554 0.194639134058819 3994 2033102 YER133W GLC7
SGTC_1465 k213-0056 144 µM -0.861675708164032 0.240739579985033 no 2555 0.194432998353248 3797 24048857 YMR208W ERG12
SGTC_1174 0739-0097 51.1 µM -0.861825605158907 0.240699672849568 no 2556 0.194391746224114 3931 728447
SGTC_1612 st002233 45.4 µM -0.862394771827108 0.240548176181513 no 2557 0.194235158282368 3917 1035021
SGTC_1972 st070201 17.4 µM -0.862507947570901 0.240518058069783 no 2558 0.194204030767263 3891 2829099
SGTC_3061 glucosamine 200 µM -0.863161339758393 0.240344218749269 no 2559 0.194024383160198 3801 91431 and experimental redox chemotherapeutic
SGTC_984 1492-0255 2.91 µM -0.86419630049734 0.240069000725266 no 2560 0.193740032079344 3894 1585198
SGTC_2692 st077426 47.7 µM -0.864594131474691 0.239963254759161 no 2561 0.193630797338154 3931 25238571
SGTC_288 1315-0019 35.1 µM -0.865723041594316 0.239663321734069 no 2562 0.193321030551301 3991 6811474
SGTC_2639 lactacystin 53 µM -0.866014515406986 0.239585915137258 no 2563 0.193241100870319 3963 3870 A proteasome inhibitor.
SGTC_828 2074-0507 139 µM -0.86627622221942 0.239516425381722 no 2564 0.193169351261202 4014 X828
SGTC_3009 9080819 71.4286 µM -0.866920458276375 0.239345411365097 no 2565 0.192992796634567 3940 17027216
SGTC_3069 9117009 49.47 µM -0.867262469376767 0.239254650802361 no 2566 0.192899107628038 3881 41904981
SGTC_790 1575-0012 79.1 µM -0.871041668799459 0.238253005701927 no 2567 0.191865700891241 4014 378741 YLR208W SEC13
SGTC_993 3909-8757 62.7 µM -0.871204874707387 0.238209801150888 no 2568 0.191821149373052 3902 4288324 YLR208W SEC13
SGTC_3297 9117502 71.43 µM -0.874743192617536 0.237274178907788 no 2569 0.190856826433991 3938 7453720
SGTC_2282 7944268 200 µM -0.875278182097489 0.237132889794808 no 2570 0.190711281233368 3949 2970414
SGTC_1968 st069590 43.6 µM -0.877675911386872 0.236500224896748 no 2571 0.190059810258986 3954 6384066
SGTC_2953 9074162 66.49 µM -0.879262055135029 0.236082216017236 no 2572 0.189629602350761 3907 16451992
SGTC_2653 dihydrofissinolide 100 µM -0.883305443930535 0.235018473831478 no 2573 0.188535631627782 3988 6857746
SGTC_94 0334-0113 514.748 µM -0.884557912988087 0.234689509918458 no 2574 0.188197557232883 3968 6795178
SGTC_1788 fluconazole 20 µM -0.886542706096913 0.234168721225068 no 2575 0.187662575973867 4008 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1725 st036284 20.55 µM -0.886744934316186 0.234115694624961 no 2576 0.187608120155948 4053 707914
SGTC_2217 6934799 96.0675 µM -0.886884641348762 0.234079065693869 no 2577 0.187570505685141 3880 675606
SGTC_1928 4'-methoxychalcone 40.3 µM -0.887037604252577 0.234038964927198 no 2578 0.187529327571901 4004 641818
SGTC_1905 st060207 84.5 µM -0.888455729369117 0.233667370355595 no 2579 0.187147829683951 3899 1948547
SGTC_2365 9042475 200 µM -0.889002488331441 0.233524189268633 no 2580 0.187000871247564 4039 6464479
SGTC_107 0358-0022 2.6945 µM -0.890026566576193 0.233256142398062 no 2581 0.186725810596143 3987 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_988 1497-1057 103 µM -0.892546424005544 0.232597311109134 no 2582 0.186050060581177 3875 3533044
SGTC_1469 k284-2957 126 µM -0.893525702751298 0.232341552436996 no 2583 0.185787857039064 3927 23884841
SGTC_566 0958-0068 16.5 µM -0.894633598096047 0.232052391624211 no 2584 0.185491492675729 3859 6815365
SGTC_1888 azatryptophan 97.5 µM -0.895311672534869 0.231875512999397 no 2585 0.185310251151877 4003 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_61 0978-8327 98.565 µM -0.895606773690761 0.231798558055538 no 2586 0.185231408347287 3905 6150059 YHR072W ERG7
SGTC_3219 9131112 49.47 µM -0.896689229097252 0.231516402812554 no 2587 0.184942384817981 3903 17612988 YMR079W SEC14
SGTC_1835 st008666 49.2 µM -0.896853173378622 0.231473685431942 no 2588 0.184898634941249 3904 690455
SGTC_1772 st048439 82.2 µM -0.897002281895147 0.231434837479788 no 2589 0.184858849695569 4012 2927068 YDL195W SEC31
SGTC_3343 9148379 18.9835 µM -0.899232863314741 0.230854127640517 no 2590 0.184264319565422 4016 1955036
SGTC_280 3448-3607 3.04 µM -0.899280677498428 0.23084168860444 no 2591 0.184251588406812 3948 626179
SGTC_2214 7179297 48.276 µM -0.901008441869394 0.230392455546616 no 2592 0.183791915617079 3982 769744
SGTC_2279 7948423 32.93 µM -0.90192147996895 0.230155255607341 no 2593 0.183549290012769 3900 1247112
SGTC_399 oxolinic acid 75 µM -0.902213609619421 0.230079391536679 no 2594 0.183471703294933 3933 4628 A DNA gyrase inhibitor.
SGTC_1005 4092-0690 4.4 µM -0.903310072066131 0.229794772593834 no 2595 0.183180676219423 4007 1529343
SGTC_1563 conessine 56.1 µM -0.904461800362658 0.229496020200521 no 2596 0.182875290532947 4039 441082 An anti-amoebic, histamine inhibitor.
SGTC_1207 2099-0101 141 µM -0.905685367335069 0.229178871796283 no 2597 0.182551204835474 4007 5837381
SGTC_2178 5812956 200 µM -0.905966128652849 0.229106133184271 no 2598 0.18247689032497 3932 5403383
SGTC_97 0535-0701 19.132 µM -0.906070752762943 0.229079030865968 no 2599 0.182449202278564 3894 2832013 YGL099W LSG1
SGTC_1487 3970-0795 2.82 µM -0.906201030530843 0.229045285618434 no 2600 0.182414728838071 4011 3765103
SGTC_538 2922-0838 53.3 µM -0.906207003512423 0.22904373853151 no 2601 0.182413148395626 3945 777039
SGTC_3244 9134489 49.47 µM -0.906789073867872 0.228893002180734 no 2602 0.182259174443929 3990 16584271
SGTC_64 000l-0018 272.079 µM -0.909235398993196 0.228260096547008 no 2603 0.181612941171832 3921 6811119
SGTC_495 decylubiquinone 155 µM -0.90994659353655 0.228076283238303 no 2604 0.181425337879787 4031 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2259 7964009 200 µM -0.910167283184735 0.228019261350656 no 2605 0.181367147673797 4034 313134
SGTC_2968 9090663 33.37 µM -0.91046624457264 0.227942028366974 no 2606 0.181288337855367 3949 25236811
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.911341942571216 0.227715887307499 no 2607 0.181057616758423 3989 688669
SGTC_714 4296-0578 26.1 µM -0.912769062516854 0.227347617283978 no 2608 0.180682006333995 4016 1589775
SGTC_3124 9127567 49.47 µM -0.913002728966103 0.227287351359561 no 2609 0.180620553140418 3986 17592030
SGTC_867 0518-0118 155 µM -0.913582814190044 0.227137777991458 no 2610 0.180468050081894 3968 6848158
SGTC_300 r073-0011 5.04 µM -0.91727145652419 0.226187971018213 no 2611 0.179500205331017 3982 2735780
SGTC_1067 clotrimazole 1.36 µM -0.918095869498355 0.22597599605594 no 2612 0.17928433856438 4000 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1418 3966-3099 2.4 µM -0.918217954533664 0.225944614820587 no 2613 0.179252385335957 3971 740335
SGTC_2397 5161689 200 µM -0.919112746495323 0.2257146890678 no 2614 0.179018301413357 4037 2259942
SGTC_1852 st056254 31.4 µM -0.919574815558917 0.225596007640383 no 2615 0.178897496212289 3927 442583
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.921063300777318 0.225213933666274 no 2616 0.178508689584926 4046 688788
SGTC_810 3825-7150 143 µM -0.922985569134727 0.224721056192898 no 2617 0.178007362817824 4069 22330411 YGL099W LSG1
SGTC_1413 3910-0535 34.4 µM -0.923776377555935 0.224518467409349 no 2618 0.17780137830362 3994 2876951
SGTC_610 4215-0184 155 µM -0.924879414519526 0.224236065276678 no 2619 0.177514317813569 4022 5605015
SGTC_3232 9132874 49.47 µM -0.928174505723455 0.223393650482085 no 2620 0.176658528321953 3954 3784940
SGTC_835 0312-0010 67.2 µM -0.930104247850199 0.22290113469922 no 2621 0.176158555813047 3958 1626196
SGTC_311 1315-0136 58 µM -0.930350979729646 0.222838207526577 no 2622 0.176094695250364 4061 6759207
SGTC_2413 inermin 26.06 µM -0.93059102533735 0.222776995354311 no 2623 0.176032579333855 4115 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_542 3381-0244 89.3 µM -0.931911191524612 0.222440521298863 no 2624 0.175691211683245 4047 1112843
SGTC_573 3702-0553 84.7 µM -0.933101696317625 0.22213734306034 no 2625 0.175383731691669 3953 1222756
SGTC_1604 st002052 72.4 µM -0.934637326383504 0.221746622514101 no 2626 0.17498761796274 4078 6254834 YHR062C RPP1
SGTC_509 pifithrin 175 µM -0.934659854943668 0.221740893346845 no 2627 0.174981810978818 4049 4817 A p53 inhibitor.
SGTC_2049 5262831 67.185 µM -0.935488286133769 0.221530276355985 no 2628 0.174768358658362 4027 763417
SGTC_103 0844-0104 51.839 µM -0.935845303891353 0.221439544877625 no 2629 0.174676420991606 3956 5375804
SGTC_1100 amiodarone 5.07 µM -0.937286792377716 0.221073425230667 no 2630 0.174305527474811 4110 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_79 0052-0007 94.094 µM -0.93960778063765 0.220484652389005 no 2631 0.173709391889511 3991 2801472
SGTC_329 k048-0121 21.3 µM -0.940491692774719 0.220260663936293 no 2632 0.173482704399153 4037 6832902
SGTC_369 0957-0393 4.5 µM -0.941183473331538 0.220085453789184 no 2633 0.173305422241109 4064 6997992
SGTC_1983 st071813 46.9 µM -0.944667254955988 0.219204317897256 no 2634 0.172414389702503 4082 11838595
SGTC_1403 3909-7815 62.9 µM -0.945196176276959 0.219070717950229 no 2635 0.172279365615991 3977 6615483
SGTC_2098 5376439 882.5 nM -0.945452971996521 0.219005870948851 no 2636 0.172213834630312 4063 2844116
SGTC_2198 6589944 200 µM -0.945755742075957 0.218929428516121 no 2637 0.172136592010864 4019 5290268
SGTC_1342 1486-1464 234 µM -0.946038543425592 0.218858041590554 no 2638 0.172064463783509 4062 3253938
SGTC_1743 st037606 46.3785 µM -0.948479662892372 0.218242392135286 no 2639 0.171442660643196 3992 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_3299 9121982 43.1275 µM -0.948981805229538 0.218115875874866 no 2640 0.171314933016208 4095 17594604 YPL160W CDC60
SGTC_1103 duloxetine 36.1 µM -0.949110472932011 0.218083464468214 no 2641 0.171282214200683 4120 60835 A selective serotonin reuptake inhibitor.
SGTC_3318 9139014 38.6185 µM -0.951434015543646 0.217498641776223 no 2642 0.170692049847002 4023 16643984
SGTC_1326 1431-2094 10.8 µM -0.951635454808368 0.217447983317524 no 2643 0.170640946999964 4023 616278
SGTC_1479 0549-0158 134 µM -0.951670455312706 0.217439181996304 no 2644 0.170632068769506 4051 5440202
SGTC_1010 4112-3296 15.2 µM -0.952260352597072 0.217290875780118 no 2645 0.170482479875071 4114 704384
SGTC_3238 9133470 49.47 µM -0.952878586360411 0.217135508196617 no 2646 0.170325795440464 4032 3534688
SGTC_1140 3229-1848 2.98 µM -0.955051147712927 0.216590033750244 no 2647 0.16977591599585 4057 2849525
SGTC_692 k241-0027 77.8 µM -0.955781512209629 0.21640683614761 no 2648 0.169591315316319 4093 3600480
SGTC_3269 9137823 49.47 µM -0.957732560691468 0.215917893912373 no 2649 0.16909881671038 3938 17682936
SGTC_3200 9114385 49.47 µM -0.961773088257629 0.214907356028484 no 2650 0.16808179960108 4098 17018030 YLR208W SEC13
SGTC_2546 rhodinyl acetate 100 µM -0.962725702647087 0.21466950750878 no 2651 0.167842597284153 3989 6708682
SGTC_2642 cholecalciferol 100 µM -0.963127280522008 0.214569287503207 no 2652 0.167741826424133 4047 9821465 A vitamin D precursor, similar to steriods.
SGTC_2470 5664817 21.68 µM -0.963727184937588 0.214419622699078 no 2653 0.16759136062885 4064 2859561
SGTC_1293 1000-1278 195 µM -0.96744727130284 0.213492887888777 no 2654 0.16666024427784 4107 678847
SGTC_3195 9113082 49.47 µM -0.967753621198728 0.213416675253524 no 2655 0.166583715714045 3999 17018038
SGTC_350 k064-0020 19.8 µM -0.968041008418468 0.213345194503799 no 2656 0.166511944795151 4079 2790705
SGTC_2281 7943571 200 µM -0.968435881231829 0.213247002031778 no 2657 0.166413363420576 4162 1244024
SGTC_1840 st055363 71 µM -0.968930879724184 0.213123948678613 no 2658 0.166289838559857 4098 676033
SGTC_1903 st060211 78.3 µM -0.969283913453099 0.213036212136713 no 2659 0.166201776614168 4099 688960
SGTC_1855 st056195 39.6 µM -0.971829982919193 0.212404082912297 no 2660 0.165567568523416 4007 4028379
SGTC_1217 1183-1422 255 µM -0.972826912892631 0.21215686750944 no 2661 0.165319667221835 4079 2849664
SGTC_2814 7977482 42.97 µM -0.974103616490819 0.211840520548989 no 2662 0.165002547024431 4133 6456762
SGTC_215 1287-0124 461.5 µM -0.975317820032045 0.211539916316715 no 2663 0.164701316874351 4080 5560863
SGTC_1019 4262-0212 3.4 µM -0.978253668099584 0.210814111887623 no 2664 0.163974439423021 4080 4677213
SGTC_794 k038-0031 316 µM -0.978903999241406 0.210653533939102 no 2665 0.163813707985648 4054 6624242
SGTC_789 1309-1135 70.6 µM -0.980284249135302 0.210312964366322 no 2666 0.163472913714839 4044 3092424
SGTC_1382 3002-2117 298 µM -0.980324372098837 0.210303069069261 no 2667 0.163463013939902 4141 1497314
SGTC_2938 9059746 27.26 µM -0.981163231611316 0.210096248558917 no 2668 0.163256126369141 4072 6471769
SGTC_2899 9053889 58.44 µM -0.982128205910711 0.209858482341513 no 2669 0.163018345679909 4038 6470052
SGTC_552 k242-0005 476 µM -0.982359187942049 0.209801592664439 no 2670 0.162961462479624 4155 4088318
SGTC_1994 st072947 40.9 µM -0.983768631174305 0.209454650599032 no 2671 0.162614643083036 4130 5286565 YDL195W SEC31
SGTC_1634 st006576 41 µM -0.984805601059161 0.209199610530637 no 2672 0.162359784435242 4083 3915356
SGTC_1647 st011722 22.4 µM -0.986342087904314 0.208822051873203 no 2673 0.161982636548716 4048 2854783
SGTC_2141 5621638 7.665 µM -0.986851867614438 0.208696873212243 no 2674 0.161857631595816 4101 2856238
SGTC_2253 7938677 135.83 µM -0.989008029259931 0.208167907540125 no 2675 0.161329606625647 4153 2301972
SGTC_1407 3909-7909 12.3 µM -0.990627665000405 0.20777108728647 no 2676 0.160933711900344 4058 4411780
SGTC_2441 5730946 39.09 µM -0.990748264262915 0.207741557643935 no 2677 0.160904258678215 4130 1774275
SGTC_525 k781-2675 26.7 µM -0.991158983946089 0.207641008420168 no 2678 0.160803977515307 4042 3651118 YDL195W SEC31
SGTC_1190 1486-1332 13 µM -0.992247711151827 0.207374613798922 no 2679 0.16053835178396 4075 4150046
SGTC_2227 7312221 64.1025 µM -0.998716437770641 0.205795988549408 no 2680 0.158966037741261 4166 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_939 1165-0479 45.3 µM -1.00133758637169 0.205158360044695 no 2681 0.158331813647353 4079 1377347
SGTC_3048 9093155 49.47 µM -1.00205773787463 0.204983379616249 no 2682 0.158157853893225 4054 25236002
SGTC_312 4092-0653 6.84 µM -1.00229512940568 0.204925718324796 no 2683 0.158100537110532 4042 1148278
SGTC_3350 9150499 3.57 µM -1.0026704664999 0.204834570381848 no 2684 0.15800994201061 4068 4910996 YPR165W RHO1
SGTC_998 3996-0085 177 µM -1.00277238250876 0.204809824966746 no 2685 0.157985348432147 4115 715391
SGTC_3249 9135183 49.47 µM -1.00337549160983 0.204663425238514 no 2686 0.157839862278798 4103 4902779
SGTC_1175 0741-0056 27.6 µM -1.00585343526207 0.204062578662346 no 2687 0.157243039222224 4186 765927
SGTC_2504 purpurogallin 52.29 µM -1.00617323576681 0.20398511074122 no 2688 0.157166122182878 3999 5281571 An antioxidant.
SGTC_1033 k072-0102 21.3 µM -1.00750928268559 0.20366165861766 no 2689 0.156845049578474 4082 5965931
SGTC_3024 9090631 49.47 µM -1.00923434329586 0.203244480346908 no 2690 0.156431129843771 4070 25236383
SGTC_1152 3909-8331 15.9 µM -1.00927569799188 0.203234485640228 no 2691 0.156421215826903 4064 16001939
SGTC_1406 3909-7906 11.9 µM -1.01090791824671 0.202840240877372 no 2692 0.156030251928168 4112 X1406
SGTC_938 3126-1755 342 µM -1.01126335741212 0.202754449092029 no 2693 0.155945199446788 4102 1777771
SGTC_591 4299-0174 154 µM -1.01363043486932 0.202183664556735 no 2694 0.155379564756304 4110 5509088
SGTC_2753 fluvastatin 17.09 µM -1.01371856425484 0.2021624320819 no 2695 0.155358531611952 4124 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_266 formosanin C 406 nM -1.01379274526729 0.202144561137547 no 2696 0.155340828872065 3992 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1831 st055328 12 µM -1.01462935943338 0.201943077907912 no 2697 0.155141269373542 4107 1103068
SGTC_2478 5763493 32.33 µM -1.01565084368978 0.201697235160795 no 2698 0.154897841970862 4039 1365576 YLR208W SEC13
SGTC_709 3807-1509 243 µM -1.01640638862322 0.201515511965568 no 2699 0.154717952313514 4162 1886677 YPL242C IQG1
SGTC_1262 0737-0114 49.6 µM -1.01662583343252 0.201462749627563 no 2700 0.154665730007206 4186 765919
SGTC_3251 9135047 49.47 µM -1.01776712374399 0.201188476354771 no 2701 0.154394319656698 4134 17682963
SGTC_606 k015-0008 38.6 µM -1.01839002861717 0.201038875233559 no 2702 0.154246319506391 4202 1970475
SGTC_2966 9084041 48.03 µM -1.01879464498684 0.200941735539978 no 2703 0.154150234270099 4010 17741380
SGTC_2848 9016370 25.97 µM -1.02001888480903 0.200647993422597 no 2704 0.153859752224236 4106 7894410
SGTC_1181 1222-0449 220 µM -1.02105205495973 0.200400296949249 no 2705 0.153614888380393 4184 658318
SGTC_3209 9113616 49.47 µM -1.02338723103837 0.199841129368814 no 2706 0.153062397154013 4178 16649353
SGTC_1529 apigenin 74 µM -1.02637700199141 0.199126587797226 no 2707 0.152356957050532 4150 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2387 9077560 195.08 µM -1.02841743082538 0.198639819454649 no 2708 0.151876756306232 4112 5303272
SGTC_2301 7769476 200 µM -1.02894077609389 0.198515085003016 no 2709 0.151753752840213 4145 977820
SGTC_725 1497-0963 19 µM -1.0295944837991 0.198359346271205 no 2710 0.151600202899858 4224 3549977
SGTC_515 4092-1064 102 µM -1.02997854409779 0.19826788248657 no 2711 0.151510038839555 4161 717353
SGTC_1554 st069299 38.7 µM -1.03015441852682 0.198226006570567 no 2712 0.151468761517027 4103 24207999
SGTC_1933 st074711 15.9 µM -1.03345406358078 0.19744134713301 no 2713 0.150695728560351 4096 17250958
SGTC_1209 2323-2347 50.3 µM -1.03411875431667 0.197283510483951 no 2714 0.150540324872022 4134 5412760
SGTC_1143 3454-2408 5.08 µM -1.03448848305095 0.197195748195751 no 2715 0.150453929071849 4107 X1143
SGTC_2249 haloperidol 116.36 µM -1.03531424802551 0.196999822168529 no 2716 0.150261088990916 4114 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1009 4106-0057 9.87 µM -1.03546503400779 0.196964058494438 no 2717 0.150225893882482 4136 2928005
SGTC_2448 5185112 27.17 µM -1.03828790862789 0.196295250066625 no 2718 0.149568018123796 4162 5718189
SGTC_3101 9120531 49.47 µM -1.03855359592718 0.19623237317753 no 2719 0.149506198386432 4155 24824904
SGTC_805 3852-0218 479 µM -1.03895863790138 0.196136540463394 no 2720 0.149411986624613 4098 6615355
SGTC_1366 1683-0113 21.9 µM -1.03977373274695 0.195943775507235 no 2721 0.149222517720471 4137 708623
SGTC_1711 st032263 62.8 µM -1.04037345179884 0.195802019036116 no 2722 0.149083215443278 4137 3958979
SGTC_1086 cerivastatin 2.18 µM -1.04096244300409 0.195662858919365 no 2723 0.148946489592537 4115 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1619 st003326 88.7 µM -1.04119779922069 0.195607268434108 no 2724 0.148891878460823 4130 2849032
SGTC_1448 4255-0083 152 µM -1.04198888716088 0.19542048595648 no 2725 0.14870841559879 4209 5399660
SGTC_3265 9137266 49.47 µM -1.04226873791645 0.195354436802435 no 2726 0.148643551020779 4059 17224265
SGTC_438 sphingosine 6.67 µM -1.04396230661047 0.194955017553416 no 2727 0.148251414629697 4077 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2958 9077254 16.72 µM -1.04508857414108 0.194689668414241 no 2728 0.147991017171777 4220 16457351
SGTC_2917 7979103 53.79 µM -1.0453798364708 0.194621082653698 no 2729 0.147923726034851 4183 2980565
SGTC_2724 maprotiline 69.64 µM -1.04578205685977 0.194526392926969 no 2730 0.147830833630672 4056 4011 A tricyclic antidepressant.
SGTC_2371 9071574 200 µM -1.04629469195246 0.194405750293293 no 2731 0.14771249768233 4143 45596039
SGTC_359 0081-0058 15.9 µM -1.04649877650539 0.194357734075596 no 2732 0.14766540475686 4246 3494159
SGTC_1687 st020778 55.3625 µM -1.04721104701418 0.194190210431672 no 2733 0.147501125686037 4159 4259299
SGTC_331 k048-0133 24.5 µM -1.04970318429211 0.193604760580808 no 2734 0.146927299638888 4103 6813582
SGTC_1370 2001-0092 44.6 µM -1.05032835267911 0.193458065838421 no 2735 0.146783586971032 4203 790957
SGTC_1893 st059353 36.1 µM -1.05043903427422 0.193432101649523 no 2736 0.146758153499539 4161 3112488
SGTC_3233 9132340 49.47 µM -1.0508423588104 0.193337505946492 no 2737 0.146665498763455 4143 17682950
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.05229979504464 0.192995914345727 no 2738 0.146331012845993 4165 2374 Ca(2+)-ATPase inhibitor.
SGTC_1715 st032160 10.2275 µM -1.05244342498519 0.192962270549126 no 2739 0.146298077099132 4082 5289825
SGTC_2020 4017018 200 µM -1.05289649612469 0.192856166891463 no 2740 0.146194216085414 4204 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1341 1486-1360 280 µM -1.05426609280864 0.192535641050845 no 2741 0.145880553986751 4131 3976547
SGTC_1104 tacrolimus 29.8 µM -1.05459912363342 0.192457751304489 no 2742 0.145804352386947 4189 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_463 ikarugamyin 104 µM -1.05892519690503 0.191447714169469 no 2743 0.14481692400453 4269 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2202 7226349 200 µM -1.05959160328131 0.191292413044335 no 2744 0.144665217623489 4108 844334
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.05992287293727 0.191215241818755 no 2745 0.144589844445678 4100 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1674 st016616 23.6 µM -1.06301973200524 0.190494733718557 no 2746 0.14388650155426 4103 625830
SGTC_544 k015-0020 52.4 µM -1.06335571969428 0.190416663960412 no 2747 0.143810332755273 4165 3008304
SGTC_1973 st070275 50.2 µM -1.06341015455355 0.190404017381612 no 2748 0.143797994870698 4110 17118334
SGTC_1605 st000082 49.1 µM -1.0646912670307 0.190106531864278 no 2749 0.143507831642502 4124 1114022
SGTC_1450 4112-4260 37.6 µM -1.06486226688563 0.19006684582096 no 2750 0.143469131263498 4154 1633175
SGTC_2741 miltefosine 3.04 µM -1.06942884755072 0.18900890752409 no 2751 0.142438237168829 4166 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1078 idebenone 36.1 µM -1.06951736840397 0.18898843582991 no 2752 0.142418303439127 4206 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1618 st003135 44.5 µM -1.07131526177353 0.188572943308815 no 2753 0.142013849907694 4127 1270615
SGTC_746 1095-0025 46.6 µM -1.07245831286375 0.188309077706565 no 2754 0.141757114196761 4173 6749286
SGTC_3119 9125183 49.47 µM -1.07322112737859 0.188133113933389 no 2755 0.141585956755878 3977 22695334
SGTC_3149 9097855 49.47 µM -1.07390197675263 0.187976143371976 no 2756 0.141433308641748 4172 25236625 YMR079W SEC14
SGTC_3021 9087658 49.47 µM -1.07455768982395 0.187825044470388 no 2757 0.141286401616677 4177 25237042
SGTC_201 4262-0159 12.803 µM -1.07608398761877 0.187473623433738 no 2758 0.14094484810285 4199 1341029
SGTC_1979 st071809 45.3 µM -1.07644842561779 0.187389773876987 no 2759 0.140863377404009 4263 4976333
SGTC_2224 6650123 117.647 µM -1.07857715678779 0.186900460696018 no 2760 0.140388134535273 4160 2908370
SGTC_2522 biochanin a 4.94 µM -1.07950674687318 0.186687032036307 no 2761 0.140180943876464 4184 5280373 A possible chelator.
SGTC_1295 1013-0063 9.78 µM -1.08086381486573 0.186375727890635 no 2762 0.139878848397561 4194 6826038
SGTC_3007 9078383 71.4286 µM -1.08191727611906 0.1861342913569 no 2763 0.139644643778835 4159 6496995
SGTC_2709 st078560 56 µM -1.08391701345905 0.1856765169758 no 2764 0.13920079769458 4183 17250903
SGTC_2689 tacrolimus 100 µM -1.08741357300328 0.184877774300989 no 2765 0.138427037677536 4202 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2563 tomatine 8.54 µM -1.08820345001348 0.184697633485109 no 2766 0.138252651013171 4141 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_3348 9149464 3.537 µM -1.08844378769568 0.184642843288545 no 2767 0.138199619715512 4132 1951442
SGTC_1034 k072-0165 12.7 µM -1.08913685736246 0.184484899600223 no 2768 0.138046769293284 4209 5835461
SGTC_1591 genipin 88.4 µM -1.09172500701766 0.183895829196139 no 2769 0.137476995065275 4213 442424 A DNA cross-linking agent.
SGTC_1464 k208-0027 110 µM -1.09267847601905 0.183679112461206 no 2770 0.137267496672799 4194 X1464
SGTC_660 4031-1742 102 µM -1.09300676624118 0.183604531266456 no 2771 0.137195414481691 4076 6738706
SGTC_925 2064-1272 59.6 µM -1.09334690875085 0.183527277369574 no 2772 0.137120757179026 4165 6815817
SGTC_1466 k213-0079 57.5 µM -1.09677364211294 0.182750120876303 no 2773 0.136370177529079 4115 3657981
SGTC_2280 7785178 200 µM -1.0976539266983 0.182550811330108 no 2774 0.136177817709845 4180 2954328
SGTC_959 1222-0044 107 µM -1.09834032308924 0.182395495197117 no 2775 0.136027955253175 4193 6083612
SGTC_2427 5545055 42.75 µM -1.09864790357938 0.182325923414364 no 2776 0.135960837162276 4141 5372858
SGTC_966 1300-0360 30.2 µM -1.10126082593108 0.181735574153969 no 2777 0.135391577730741 4172 70588
SGTC_2487 5918373 44.05 µM -1.10162183302701 0.181654104331754 no 2778 0.135313056222211 4271 2876279
SGTC_1709 st033179 39.1045 µM -1.10381577236293 0.181159481427167 no 2779 0.134836530777111 4183 573381
SGTC_2862 9027634 71.43 µM -1.10471389123411 0.180957244413929 no 2780 0.134641791135035 4145 5012562
SGTC_1771 st048882 4.1505 µM -1.10547492107119 0.180785987675638 no 2781 0.134476927741389 4228 4580403
SGTC_2247 cerulenin 830 nM -1.10657498555234 0.180538616641011 no 2782 0.134238863643641 4265 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_757 1066-0008 322 µM -1.10671736583993 0.18050661517004 no 2783 0.134208072406305 4240 6842497
SGTC_907 3448-6986 75.5 µM -1.10757477225268 0.18031397927286 no 2784 0.134022751806332 4236 590582
SGTC_2034 5197015 53.07 µM -1.10762480065285 0.180302743236821 no 2785 0.134011944054154 4209 780676
SGTC_3287 9117173 37.0625 µM -1.1083324752909 0.180143851427083 no 2786 0.133859127596554 4190 2789709
SGTC_332 4112-0506 40.9 µM -1.10943632959986 0.179896182269491 no 2787 0.133620998625742 4163 2790355
SGTC_1492 4158-0558 28.5 µM -1.11213064330732 0.179292564091894 no 2788 0.133040991518376 4213 3967268
SGTC_3089 9117425 49.47 µM -1.11226884504594 0.179261636567362 no 2789 0.133011287515215 4209 9401657
SGTC_444 curcumin 90.4 µM -1.11253976740076 0.179201017849099 no 2790 0.132953070826373 4140 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2083 5306046 65.942 µM -1.11271996410636 0.179160706082191 no 2791 0.132914359279624 4211 539837
SGTC_2152 5568786 200 µM -1.11283465949415 0.179135050572288 no 2792 0.132889723382639 4210 5399883
SGTC_2647 atorvastatin 60.16 µM -1.113063424147 0.17908388650807 no 2793 0.132840595465973 4175 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1414 3917-0015 5.4 µM -1.11396227813646 0.17888294351583 no 2794 0.132647684908843 4193 6618702
SGTC_1726 st035556 14.5795 µM -1.11589221968678 0.17845197577561 no 2795 0.132234136277761 4289 5919439
SGTC_2852 9023854 51.95 µM -1.12388514501913 0.176674078781813 no 2796 0.130530877013431 4265 19798528
SGTC_764 1951-2361 146 µM -1.1238861141808 0.176673863888815 no 2797 0.130530671413242 4223 5438930
SGTC_1749 st037932 54.2 µM -1.12452847008433 0.176531470153865 no 2798 0.130394449813378 4245 594497
SGTC_1756 st041558 35.5 µM -1.12655658556541 0.1760823658111 no 2799 0.129965001742564 4300 3955792
SGTC_1480 1070-0044 41.2 µM -1.12739286720666 0.175897391044889 no 2800 0.129788206736155 4235 3124987
SGTC_2857 9024691 58.44 µM -1.13243832495294 0.174784012908549 no 2801 0.128725099988421 4308 16478292
SGTC_2517 totarol 10 µM -1.13348968114665 0.174552575182664 no 2802 0.128504336048267 4240 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1454 4239-0054 42.6 µM -1.13742155644587 0.173688767349267 no 2803 0.127681050016161 4332 1340767
SGTC_3003 9075612 71.4286 µM -1.13789797259682 0.173584286805987 no 2804 0.127581543976874 4250 6501993
SGTC_1927 st060202 13.8 µM -1.13922567955424 0.173293324838895 no 2805 0.12730451873893 4130 688887
SGTC_774 k060-0086 136 µM -1.14085905532778 0.172935802965452 no 2806 0.12696429026325 4245 5911235
SGTC_295 k015-0027 31 µM -1.14198643548459 0.172689310417219 no 2807 0.126729829016394 4276 3887424
SGTC_2375 9072683 200 µM -1.14355822663974 0.172346025014109 no 2808 0.126403447070358 4316 16798029
SGTC_445 e6 berbamine 66 µM -1.14547133750053 0.171928781876382 no 2809 0.126006981029591 4262 6610268 A calcium/calmodulin antagonist.
SGTC_2975 9084847 53.72 µM -1.14728185336239 0.171534508891329 no 2810 0.125632575710816 4295 27211724
SGTC_2066 5222451 176 µM -1.14791826493335 0.171396055963844 no 2811 0.125501153647373 4196 2281147
SGTC_345 1362-0200 395 µM -1.15138394639314 0.170643342397475 no 2812 0.124787157649437 4231 1419823
SGTC_2013 4024628 200 µM -1.15285304181142 0.170324908249786 no 2813 0.124485354460505 4288 5230760
SGTC_719 2810-4230 27.3 µM -1.1548246452252 0.169898151482925 no 2814 0.124081121281035 4245 721079
SGTC_2816 7982706 58.44 µM -1.15948377483425 0.168892402082589 no 2815 0.12312952319128 4259 2981853
SGTC_1055 3448-0672 86 µM -1.16019714995432 0.16873874672989 no 2816 0.122984273550563 4245 748378
SGTC_1747 st037496 66.6 µM -1.16023369256951 0.168730878159466 no 2817 0.122976836378526 4220 723305
SGTC_2223 6903751 107.57 µM -1.16098301385043 0.168569581896541 no 2818 0.122824403640263 4210 5598863
SGTC_470 aa-861 153 µM -1.1611741996905 0.168528443782109 no 2819 0.122785532361554 4214 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_785 1270-0111 65.3 µM -1.16213081857998 0.168322701763228 no 2820 0.122591165331013 4173 6741994
SGTC_846 0335-0850 148 µM -1.16334066560416 0.168062728900362 no 2821 0.1223456563597 4218 6819598
SGTC_1817 st052116 64.4 µM -1.1647293631451 0.167764643187054 no 2822 0.122064279670126 4279 4361398
SGTC_2284 7945075 39.21 µM -1.16867264394254 0.166920069983231 no 2823 0.121267773854757 4236 1245402
SGTC_2617 dihydrotanshinone i 20.83 µM -1.16976490260939 0.166686615520914 no 2824 0.121047795705951 4223 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_229 benomyl 22.8748 µM -1.17133270718392 0.166351888466673 no 2825 0.120732534723366 4278 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1026 k007-1105 30.6 µM -1.17526000957182 0.165515314336646 no 2826 0.11994535421051 4239 7066794
SGTC_2425 5628681 7.85 µM -1.17737357158223 0.165066222321753 no 2827 0.119523216789998 4334 5714958
SGTC_2131 toluylene red 5.2905 µM -1.18504153030674 0.163443555461989 no 2828 0.118000513495799 4232 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2946 9065502 71.43 µM -1.18742336942201 0.162941635030805 no 2829 0.117530333281331 4100 16489101
SGTC_1880 MG-132 525 µM -1.1927334660041 0.161826259903577 no 2830 0.116486887320712 4224 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1988 st071872 53.4 µM -1.19628048650183 0.161083993419009 no 2831 0.115793560517146 4313 16414116
SGTC_384 k007-0144 5.16 µM -1.19691856391343 0.160950702438704 no 2832 0.115669148861224 4206 6824886
SGTC_1775 st081588 35.1725 µM -1.19930217346281 0.160453416034636 no 2833 0.115205235145586 4289 1426443 YGL099W LSG1
SGTC_702 1488-0190 94 µM -1.20070896121021 0.160160393057895 no 2834 0.114932058397859 4307 949357
SGTC_232 clozapine 119 µM -1.20112161996857 0.160074505840458 no 2835 0.114852013819991 4266 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2044 5102272 200 µM -1.20162611087538 0.159969546396313 no 2836 0.114754210188838 4281 592666
SGTC_1311 1190-0148 100 µM -1.20569080528504 0.159125528396077 no 2837 0.113968365813498 4342 1961333
SGTC_2928 9011484 9.79 µM -1.20639122705685 0.158980383721561 no 2838 0.11383333855208 4300 2994751
SGTC_678 1218-2179 85.9 µM -1.2072637391131 0.158799699073349 no 2839 0.113665295255096 4301 6820081 YOR116C RPO31
SGTC_1917 st066507 28.5 µM -1.20792773035406 0.158662286307032 no 2840 0.113537531013381 4246 3156428
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.20914858245549 0.158409834889136 no 2841 0.113302883699371 4268 756377
SGTC_912 3474-0017 2.18 µM -1.20950321496493 0.158336552342023 no 2842 0.113234788346353 4328 3360550
SGTC_3304 9125678 46.087 µM -1.21134703471899 0.157955897253263 no 2843 0.112881214737162 4223 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1642 st009582 77.7 µM -1.21445278911006 0.157316076334075 no 2844 0.112287433785605 4272 6739311
SGTC_1130 3454-2858 15.9 µM -1.21825126751935 0.156535865742441 no 2845 0.111564251384812 4293 715628 YIL048W NEO1
SGTC_1203 3992-3522 103 µM -1.21826477691414 0.15653309545598 no 2846 0.111561685327718 4409 5322312
SGTC_3142 9086498 49.47 µM -1.21947444326881 0.156285167652101 no 2847 0.111332085068412 4168 25236367
SGTC_3010 9080089 71.4286 µM -1.22109497668934 0.155953435971709 no 2848 0.111025030714783 4314 17027233
SGTC_2616 abietic acid 100 µM -1.2225544598532 0.155655069646012 no 2849 0.110749011262056 4349 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3301 9125354 19.7965 µM -1.2244992790516 0.155258070152071 no 2850 0.110381969057734 4292 41905162
SGTC_351 caspofungin 25 nM -1.22635428700382 0.154880027278992 no 2851 0.110032690277563 4304 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2797 7859098 81.82 µM -1.22929129695922 0.154282721366502 no 2852 0.109481304576714 4283 972681
SGTC_1422 4031-0024 15.5 µM -1.23226700559691 0.153679100822661 no 2853 0.108924680288835 4241 782427
SGTC_2124 5246320 200 µM -1.23327152530383 0.15347568813128 no 2854 0.10873723888936 4329 579342
SGTC_2355 9061122 103.12 µM -1.23402751096844 0.153322720609027 no 2855 0.108596326502669 4319 5302957
SGTC_2634 4'-methoxyflavone 100 µM -1.23737336801408 0.152646926946488 no 2856 0.107974250621224 4320 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_898 1000-0849 28.3 µM -1.23737362904127 0.152646874301618 no 2857 0.107974202190255 4325 6751807
SGTC_1636 st007707 68.9 µM -1.23763923875184 0.152593311455251 no 2858 0.107924929087002 4331 403051
SGTC_3025 9087895 49.47 µM -1.23847292701984 0.152425270907201 no 2859 0.107770377242505 4284 17173641
SGTC_2437 5741531 144.16 µM -1.23908924183457 0.152301123747734 no 2860 0.107656225334977 4339 2262990
SGTC_1640 st009078 66.4 µM -1.24079892745454 0.151957085284281 no 2861 0.107340018781481 4293 690618
SGTC_2336 9001819 198.65 µM -1.24227743511706 0.15165998312547 no 2862 0.107067108934386 4375 2989602
SGTC_1452 4194-0072 190 µM -1.24262168072719 0.151590863340861 no 2863 0.107003638359996 4384 1343545
SGTC_2294 7971431 200 µM -1.24432259677265 0.151249650177754 no 2864 0.106690428862444 4318 5741572
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.24874200644114 0.150365481992246 no 2865 0.105879725730679 4316 641818 YHR062C RPP1
SGTC_3150 9097574 49.47 µM -1.25436465534853 0.149245575662822 no 2866 0.104854746621055 4366 17217476
SGTC_1877 wortmannin 25 µM -1.25541823572964 0.149036347136244 no 2867 0.104663486430971 4338 312145 A covalent inhibitor of PI 3-kinase.
SGTC_921 1561-0023 372 µM -1.2574399643257 0.148635404880582 no 2868 0.104297182761015 4315 24050882
SGTC_2372 9071633 200 µM -1.25940760234786 0.148245882704579 no 2869 0.103941572456667 4376 21321366
SGTC_1278 0874-0585 172 µM -1.26081388967237 0.147967906796444 no 2870 0.103687954157742 4392 766306
SGTC_410 α-linolenic acid 100 µM -1.26138590134887 0.147854939128624 no 2871 0.10358492269488 4362 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_894 0960-0238 55.9 µM -1.26161173461895 0.147810354792125 no 2872 0.103544265784519 4327 6741907 YDL195W SEC31
SGTC_510 ag-490 170 µM -1.26567857245855 0.147009014337103 no 2873 0.102814091410665 4470 5328779
SGTC_2351 9026858 72.31 µM -1.2657900084695 0.14698709777748 no 2874 0.102794136597945 4238 1409300
SGTC_3177 9107506 49.47 µM -1.26641472089694 0.146864273696456 no 2875 0.102682321644287 4301 8897194
SGTC_3188 9110789 49.47 µM -1.26697538173583 0.146754101368289 no 2876 0.102582046339051 4322 849217
SGTC_2511 berberine 10.47 µM -1.26781106908167 0.146589988064679 no 2877 0.102432714155327 4321 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3284 9108171 64.8615 µM -1.26826326811389 0.146501236041135 no 2878 0.102351974910585 4318 8687505
SGTC_3096 9117468 49.47 µM -1.26998518029599 0.14616361067387 no 2879 0.102044954545836 4255 41316311
SGTC_1013 4112-3890 241 µM -1.27114551894425 0.145936391282486 no 2880 0.10183844213178 4287 705171
SGTC_2625 euphol 100 µM -1.27317340246096 0.145539858015008 no 2881 0.101478258261598 4353 6708538 A triterpene alcohol.
SGTC_3237 9133362 49.47 µM -1.27666115612576 0.14485955720765 no 2882 0.100860950373209 4322 43845137
SGTC_2847 9005661 71.43 µM -1.27718151985894 0.144758241963241 no 2883 0.10076908488007 4388 2991449
SGTC_349 k015-0014 24 µM -1.27940063547412 0.144326714129908 no 2884 0.100378005099628 4354 2196908
SGTC_2004 4023728 41.89 µM -1.28047004440168 0.14411906745087 no 2885 0.100189936717641 4327 360084 YDR527W RBA50
SGTC_1233 0325-0408 14.2 µM -1.28843390511423 0.142579065104229 no 2886 0.0987974813467245 4393 12874
SGTC_716 1683-5115 658 µM -1.28943276523692 0.142386700018445 no 2887 0.0986238383107578 4342 723597
SGTC_1826 st055655 41.6 µM -1.29044881068531 0.142191205510415 no 2888 0.0984474370594826 4372 676168
SGTC_486 niguldipine 82 µM -1.29274510060075 0.141750052098348 no 2889 0.0980496168035743 4427 1236 A calcium channel blocker.
SGTC_3341 9147222 25.867 µM -1.2932772291894 0.141647954268389 no 2890 0.0979575966414489 4358 1939759
SGTC_3004 9076122 71.4286 µM -1.29473865009866 0.141367812385289 no 2891 0.0977052010359068 4362 44782551
SGTC_847 0342-0274 5.54 µM -1.2952586941541 0.141268215040974 no 2892 0.0976155016229965 4360 18097
SGTC_2918 7977171 22.06 µM -1.29779813331975 0.140782552307326 no 2893 0.0971783556294393 4357 2236483
SGTC_128 0906-2981 13.371 µM -1.29903946019219 0.140545563709142 no 2894 0.096965193729657 4343 6740226
SGTC_3173 9105693 49.47 µM -1.30079589457156 0.140210696009681 no 2895 0.0966641638030521 4347 17096658
SGTC_649 1123-0311 367 µM -1.30122256191083 0.140129432916329 no 2896 0.0965911423255139 4280 693629 YIL048W NEO1
SGTC_547 1120-0019 610 nM -1.30266320840725 0.139855283720826 no 2897 0.0963448839882324 4322 3676939
SGTC_1101 ebselen 5.29 µM -1.30288802828198 0.139812534315572 no 2898 0.0963064958375035 4378 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2875 9039966 71.43 µM -1.30983454522424 0.138496033370721 no 2899 0.0951259069676637 4368 6463691
SGTC_164 4100-3994 89.624 µM -1.31040319248448 0.138388638876712 no 2900 0.0950297371018143 4366 4615967
SGTC_106 0092-0003 11.579 µM -1.31297143192275 0.137904309362934 no 2901 0.0945962873997385 4288 1072148
SGTC_2516 gossypol 71.55 µM -1.31434979156151 0.137644849830812 no 2902 0.0943642592205342 4391 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1643 st009866 20.2 µM -1.31562792282467 0.137404554970622 no 2903 0.0941494784129117 4345 3156273 YOR207C RET1
SGTC_736 0958-0254 92.6 µM -1.31885928805631 0.136798320765878 no 2904 0.0936080794682825 4444 6812352
SGTC_2383 9036125 200 µM -1.31904312713194 0.136763885898737 no 2905 0.0935773474174894 4317 79580
SGTC_3333 9141820 12.094 µM -1.32058773318003 0.13647480004142 no 2906 0.0933194326098431 4367 1939433
SGTC_2056 5235370 200 µM -1.32301675820641 0.136021033797943 no 2907 0.0929149024501159 4290 5511916
SGTC_2114 5491910 81.25 µM -1.32501992800927 0.135647599505929 no 2908 0.0925822709028951 4420 2849228
SGTC_608 k048-0125 159 µM -1.33098217306573 0.134540266576707 no 2909 0.0915974383997499 4430 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1146 3579-1023 7 µM -1.331101493968 0.134518169320099 no 2910 0.0915778087374012 4411 X1146
SGTC_2110 5483698 200 µM -1.3364103335263 0.133537536340166 no 2911 0.0907075952980232 4366 2848765 YHR062C RPP1
SGTC_3034 9090421 49.47 µM -1.34125426816492 0.132647078508375 no 2912 0.0899189561300202 4295 17173761
SGTC_1218 1348-1416 30.7 µM -1.34308263823723 0.132312035963124 no 2913 0.0896226083556327 4368 6787668
SGTC_1752 st044819 83.042 µM -1.34647145555838 0.131692590343849 no 2914 0.0890752599890132 4346 441209 YML126C ERG13
SGTC_960 1222-0186 7.7 µM -1.34785933230949 0.131439477370145 no 2915 0.088851815150961 4396 3126296
SGTC_1076 itraconazole 331 nM -1.35178466282147 0.130725417215452 no 2916 0.0882221059572531 4397 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2096 5468907 200 µM -1.35288879371385 0.130525047977455 no 2917 0.0880455799920237 4394 759785
SGTC_1748 st037455 53.6035 µM -1.35336758493514 0.130438226654879 no 2918 0.0879691138415799 4428 580690
SGTC_1628 st004252 77.7 µM -1.35703811089061 0.129773960844531 no 2919 0.087384550701117 4419 692968
SGTC_2160 5660466 132.927 µM -1.35808174374159 0.129585520019545 no 2920 0.0872188737096532 4336 2859134
SGTC_2807 7945238 51.95 µM -1.35967930928303 0.129297427102849 no 2921 0.0869657142344119 4393 17148797
SGTC_2784 7567673 72.73 µM -1.35991740610115 0.129254528558334 no 2922 0.0869280310834016 4333 3471247
SGTC_2268 7933382 153.85 µM -1.35992162862873 0.129253767863216 no 2923 0.0869273629017287 4441 935025 YOR257W CDC31
SGTC_263 alizarin 107.927 µM -1.36492218057558 0.128355087481478 no 2924 0.0861387550243332 4456 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_688 0527-0193 473 µM -1.36621122489653 0.128124130250187 no 2925 0.0859363376645973 4452 4007154
SGTC_1889 st059080 5.18 µM -1.36890865639498 0.127641767610298 no 2926 0.0855139147678049 4388 176925 Isolated from Daphnopsis sellowiana.
SGTC_913 3487-1245 167 µM -1.37068546188811 0.12732472453421 no 2927 0.0852365143664796 4363 4016153
SGTC_2846 9008642 19.48 µM -1.37437214189144 0.126668642758264 no 2928 0.0846630900757043 4446 2992898
SGTC_1916 st067606 49.2 µM -1.37588548002902 0.126400011770998 no 2929 0.0844285456296291 4325 19590279
SGTC_2300 7976697 71.57 µM -1.38219238026096 0.125284756227909 no 2930 0.0834563195556527 4317 2236109
SGTC_2834 9001755 58.44 µM -1.38335486701475 0.125079944674528 no 2931 0.083278041077129 4303 2989575
SGTC_2618 avocadyne 43.43 µM -1.38370678254329 0.1250179889295 no 2932 0.0832241279566439 4346 3015189
SGTC_2597 laccaic acid a 100 µM -1.38483920266557 0.124818768580242 no 2933 0.0830508203689426 4412 5491415 A textile dye.
SGTC_1043 0916-0009 19.3 µM -1.38488933191589 0.124809954751285 no 2934 0.0830431547778583 4441 3101130
SGTC_3105 9121040 49.47 µM -1.38690693355734 0.124455576780324 no 2935 0.0827350716677549 4370 41448907
SGTC_687 k029-0044 34.9 µM -1.38986512399369 0.123937263773426 no 2936 0.0822849189293386 4496 5829338
SGTC_2905 7799065 20.05 µM -1.39040920097044 0.123842099209336 no 2937 0.0822023270344187 4303 1296806
SGTC_393 acivicin 6.25 µM -1.39110605967833 0.123720286302805 no 2938 0.0820966338121881 4288 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_360 0957-0399 1.01 µM -1.3911295001698 0.123716190296348 no 2939 0.0820930803511832 4444 6752301 YPR165W RHO1
SGTC_3235 9132602 49.47 µM -1.39387646476028 0.123236841316968 no 2940 0.0816774562371668 4423 4912240
SGTC_2267 7931562 200 µM -1.40100959736316 0.121998182793349 no 2941 0.0806056015852744 4386 934880
SGTC_2676 harmalol 100 µM -1.40369600825351 0.121533965569769 no 2942 0.0802046958177949 4396 5459187 A monoamine oxidase inhibitor
SGTC_3186 9110464 49.47 µM -1.40443319094671 0.121406796301331 no 2943 0.0800949465327002 4422 17018021
SGTC_2719 novobiocin 32.65 µM -1.40682061892835 0.120995590176863 no 2944 0.0797402934401075 4486 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_3236 9132701 49.47 µM -1.40726349273313 0.120919418299464 no 2945 0.0796746352290752 4442 24282524
SGTC_1652 st011932 78 µM -1.40844865276714 0.120715743239114 no 2946 0.0794991306283136 4376 1551076
SGTC_2833 9001315 45.46 µM -1.40899969932345 0.120621125713597 no 2947 0.0794176285209643 4384 2989378
SGTC_3032 9089427 49.47 µM -1.4100369362401 0.120443168472823 no 2948 0.0792643883841597 4427 17173707
SGTC_2364 9055074 200 µM -1.41074889205994 0.120321126309892 no 2949 0.0791593345147857 4430 6470630
SGTC_3111 9122088 49.47 µM -1.41231957915554 0.120052190160435 no 2950 0.0789279419777737 4358 16876704
SGTC_695 3505-6186 243 µM -1.41382332825782 0.119795112488303 no 2951 0.0787068911280333 4441 1819379
SGTC_2997 9067075 71.4286 µM -1.4142577701014 0.119720913580246 no 2952 0.0786431156840148 4411 27209819
SGTC_2920 7982904 15.77 µM -1.41446609606942 0.119685344806426 no 2953 0.0786125476251255 4439 6456808
SGTC_1065 prochlorperazine maleate 2.48 µM -1.41510466224287 0.119576364911334 no 2954 0.0785189057227455 4475 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_3157 9099274 49.47 µM -1.4156151543237 0.11948929294092 no 2955 0.078444105955925 4470 17217662
SGTC_3038 9091290 49.47 µM -1.4164241390605 0.119351400262178 no 2956 0.0783256802601029 4448 25236843
SGTC_2545 solidagenone 89.61 µM -1.42228362456173 0.118355993787571 no 2957 0.0774719653769403 4355 6708572 An anti ulcer agent
SGTC_1061 3448-9325 110 µM -1.4235971265521 0.118133664304492 no 2958 0.0772815640657748 4406 723482
SGTC_1417 3966-0327 90.4 µM -1.42755008231325 0.117466351044582 no 2959 0.0767107000900819 4524 651118
SGTC_783 0848-0141 92.7 µM -1.43324938561391 0.116508935451959 no 2960 0.0758932904199111 4383 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2088 5278280 127.392 µM -1.43651437231899 0.115962956386559 no 2961 0.0754280148267083 4494 791502
SGTC_1362 1611-0397 101 µM -1.43678210242796 0.115918266619272 no 2962 0.0753899587106803 4438 27816
SGTC_1679 SEC14.276 6.7 µM -1.44163759329709 0.115109904506276 no 2963 0.074702318667752 4441 1005053 YMR079W SEC14
SGTC_845 0330-0138 4.51 µM -1.45616165156934 0.112715830313863 no 2964 0.0726739689068974 4414 9039800
SGTC_2700 st077718 96.8 µM -1.45762929549655 0.112475903790286 no 2965 0.0724713751086561 4441 904970
SGTC_2046 4110841 106 µM -1.45814380698425 0.112391879252405 no 2966 0.0724004543793977 4473 44119630 YMR134W ERG29
SGTC_1124 fisetin 1.16336 µM -1.45934121286467 0.112196505336436 no 2967 0.0722356087579199 4480 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1860 st056228 74.6 µM -1.46412129527794 0.111418985362747 no 2968 0.0715804048572076 4458 688679
SGTC_2222 6885208 172.143 µM -1.46706282894715 0.110942441496835 no 2969 0.0711794823278934 4483 609514
SGTC_733 4069-0007 56.1 µM -1.46763498534662 0.110849919025503 no 2970 0.0711016997513254 4476 5717425 YNL287W SEC21
SGTC_3263 9137018 49.47 µM -1.46882228657171 0.110658098906285 no 2971 0.0709404987561738 4430 43844957
SGTC_165 k038-0023 64.381 µM -1.47098027015635 0.110310064919334 no 2972 0.0706482263261138 4462 46368543
SGTC_2061 5245884 80.95 µM -1.47189044412867 0.110163510026713 no 2973 0.0705252322415187 4450 573863
SGTC_1027 k015-0025 8.67 µM -1.47617982589022 0.109474720022267 no 2974 0.0699478119172419 4454 3598955
SGTC_2635 hydroquinidine 100 µM -1.47657579044227 0.10941129221876 no 2975 0.0698946926107014 4412 442912 An experimental heart treatment.
SGTC_972 1319-0219 195 µM -1.4768190047889 0.109372345880508 no 2976 0.0698620803925836 4472 23903702
SGTC_2837 9008476 45.46 µM -1.48324303549797 0.108347257515111 no 2977 0.0690049255007436 4447 2992805
SGTC_1572 epiandrosterone 68.9 µM -1.48912198181126 0.107415223810898 no 2978 0.068227625164066 4435 441302 A steroid.
SGTC_1345 1488-0192 31.4 µM -1.48941391487593 0.10736909253891 no 2979 0.0681892033064826 4529 658348
SGTC_2941 9056145 11.23 µM -1.49032254729734 0.107225601819948 no 2980 0.0680697233688616 4432 2119517
SGTC_2891 9063876 19.48 µM -1.49053062445954 0.107192761858251 no 2981 0.0680423851755171 4520 6472478
SGTC_843 0310-0051 143 µM -1.49188318818605 0.106979469079913 no 2982 0.0678648853424379 4512 2065037
SGTC_2722 naftopidil 47.16 µM -1.49246035535859 0.106888545853607 no 2983 0.0677892514014547 4428 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1548 st061468 90.8 µM -1.49565703668706 0.10638597054045 no 2984 0.0673715257989366 4538 390799
SGTC_1651 st011928 86.1 µM -1.49643132043318 0.106264496448789 no 2985 0.0672706463923697 4507 720198
SGTC_1997 st073024 93.8 µM -1.49714771154272 0.106152194139294 no 2986 0.0671774137103254 4538 686268
SGTC_2600 tangeritin 87.95 µM -1.49761851155195 0.106078437680222 no 2987 0.0671161972090474 4407 68077 A bioactive flavone.
SGTC_1785 bathophenanthroline 24 µM -1.49943596043346 0.10579405990722 no 2988 0.0668802852258254 4417 72812 An iron chelator.
SGTC_2031 5180455 200 µM -1.50484961715756 0.104950246901267 no 2989 0.0661813720063019 4483 29949
SGTC_2419 paclitaxel 166.5 µM -1.50744742394915 0.104547067721866 no 2990 0.0658480053457974 4443 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_888 0916-0002 6.97 µM -1.50829001409138 0.104416539172471 no 2991 0.0657401589322903 4510 2802138 YIL048W NEO1
SGTC_529 4076-0302 30.3 µM -1.50917529583905 0.104279524375127 no 2992 0.0656269958086642 4462 5816522
SGTC_2988 9073640 71.4286 µM -1.51228982836572 0.103798524803285 no 2993 0.0652300737656317 4513 9102229
SGTC_2065 5221596 34.26 µM -1.51417750041121 0.103507782521553 no 2994 0.0649904132931583 4473 788581
SGTC_3302 9125395 16.351 µM -1.51895217803913 0.102775018212241 no 2995 0.0643872668746585 4459 17599668
SGTC_1588 farnesol 29.9 µM -1.52131240069518 0.102414192997505 no 2996 0.0640907298978024 4519 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_619 1652-1634 108 µM -1.52335010012337 0.102103416053078 no 2997 0.0638355695414548 4502 5400454
SGTC_2036 5160441 105 µM -1.5259233334259 0.101711943931417 no 2998 0.0635144794460865 4484 134534 YIL048W NEO1
SGTC_2778 tioconazole 65.09 nM -1.52778846721192 0.101428880533882 no 2999 0.0632825332910828 4407 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2334 9017922 200 µM -1.53036709278715 0.101038479217367 no 3000 0.0629629447938653 4534 3163164
SGTC_2887 9044784 58.44 µM -1.53204071188561 0.100785681800107 no 3001 0.0627561943224832 4436 6465546
SGTC_2584 androsterone 48.74 µM -1.5329506504075 0.100648430790541 no 3002 0.0626440073310119 4405 2754130 A steroid.
SGTC_994 3910-0338 138 µM -1.53344377821287 0.100574106610075 no 3003 0.062583274585825 4560 3479481
SGTC_2196 6573537 42.6665 µM -1.53359656535591 0.100551086671455 no 3004 0.062564466908774 4533 2903087
SGTC_3208 9114115 49.47 µM -1.53603445086041 0.10018429829064 no 3005 0.0622649655882618 4477 650895
SGTC_2082 5219693 150 µM -1.53930114364408 0.0996943455297207 no 3006 0.0618653974469807 4474 2834649
SGTC_391 gliotoxin 8.33 µM -1.54180261022323 0.0993203499658144 no 3007 0.0615607837968976 4553 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1976 st070609 63.5 µM -1.5429276604344 0.0991524779438734 no 3008 0.0614241643391868 4467 682556
SGTC_3068 9116768 49.47 µM -1.54299328671786 0.09914269206374 no 3009 0.0614162023868849 4483 41904888
SGTC_1008 4106-0037 6 µM -1.54828457065312 0.098356003534567 no 3010 0.0607768987967371 4546 2905394
SGTC_3019 9081971 49.47 µM -1.54971332029334 0.0981443682844458 no 3011 0.0606051697916376 4512 16451803
SGTC_2860 9025725 38.96 µM -1.55074432257962 0.0979918571997164 no 3012 0.060481484108875 4574 40546248
SGTC_83 0170-0301 39.027 µM -1.55184978387676 0.097828524775 no 3013 0.0603490853519014 4547 3089716
SGTC_2675 theaflavin digallate 100 µM -1.55333541007 0.0976093372277325 no 3014 0.0601715124300761 4453 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_570 0987-0065 62.6 µM -1.55873351622997 0.0968159385221975 no 3015 0.0595297327758525 4389 3104428
SGTC_2490 carminic acid 95.39 µM -1.56277319087225 0.096225303611501 no 3016 0.0590529760455195 4519 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_978 1416-0512 87.4 µM -1.56413387728506 0.096026957168904 no 3017 0.0588930658038401 4567 6814003
SGTC_1392 3455-1037 33.9 µM -1.56576586687957 0.0957894597449614 no 3018 0.0587017199131801 4532 981132
SGTC_3215 9129942 49.47 µM -1.56585381203254 0.0957766736921421 no 3019 0.0586914224806101 4501 17682944
SGTC_1477 0139-0234 16 µM -1.56610277961511 0.0957404839328806 no 3020 0.0586622787400827 4546 620880
SGTC_1059 3448-6867 171 µM -1.56805343602611 0.0954572859719059 no 3021 0.0584343310859342 4491 3934407
SGTC_2739 tacrine 100.86 µM -1.57174446606872 0.0949231071059904 no 3022 0.0580049126656118 4589 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2048 5246248 200 µM -1.57335719446096 0.0946903999646793 no 3023 0.0578180663856009 4541 677046
SGTC_970 1315-0089 19.5 µM -1.57483696570555 0.0944772478991448 no 3024 0.0576470407291097 4516 6811083 YLR033W RSC58
SGTC_1401 3807-4679 7.6 µM -1.57695427201109 0.0941728783075309 no 3025 0.0574030236565667 4460 3291456
SGTC_174 3553-0389 74.3 µM -1.57855253444407 0.0939436024906885 no 3026 0.0572193646040364 4547 738071
SGTC_2009 4012297 12.05 µM -1.57889989897808 0.0938938264874082 no 3027 0.0571795095987935 4490 45595307
SGTC_1637 st007924 17.4 µM -1.58091018676018 0.0936061422184336 no 3028 0.0569492874027209 4442 683336
SGTC_2934 9036370 36.88 µM -1.58124950545523 0.0935576479450827 no 3029 0.0569105000395062 4506 6462800
SGTC_1381 2324-0066 62.1 µM -1.58721550560488 0.0927080360315926 no 3030 0.0562319220747125 4554 10885928
SGTC_2906 7926292 26.41 µM -1.58839139362675 0.0925412543341707 no 3031 0.0560989311937669 4528 2966319
SGTC_3181 9108277 49.47 µM -1.5903319622061 0.0922665000058507 no 3032 0.0558799988551722 4519 17097298
SGTC_1244 0416-0015 52.5 µM -1.59616937879222 0.0914436528557582 no 3033 0.0552254911131915 4523 96201
SGTC_1241 0364-0022 50.8 µM -1.5975306203496 0.0912525555725175 no 3034 0.0550737388872946 4546 4563895
SGTC_956 1185-0240 191 µM -1.59876398115093 0.0910796665979913 no 3035 0.0549365275632142 4524 1416193
SGTC_553 k007-0256 45.7 µM -1.60132110431664 0.0907219906263838 no 3036 0.0546529085131316 4593 6287000
SGTC_663 1486-0733 13.9 µM -1.60138563916099 0.0907129773614462 no 3037 0.0546457657445564 4561 722445 YPR165W RHO1
SGTC_1876 myriocin 605 nM -1.60161015590015 0.0906816253883878 no 3038 0.054620921801602 4531 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2827 7993847 71.43 µM -1.60417280146511 0.0903243419591834 no 3039 0.0543379840887043 4578 2985692
SGTC_1602 st001878 87.6 µM -1.60562373795746 0.0901225168169942 no 3040 0.0541783032826188 4520 595405 YLR310C CDC25
SGTC_315 k915-0449 187 µM -1.61795040445328 0.0884213750894863 no 3041 0.0528366431865255 4584 20970215 YNL149C PGA2
SGTC_2145 5634607 200 µM -1.6195316837898 0.088204893750606 no 3042 0.0526664575438974 4561 308662
SGTC_2338 7999974 200 µM -1.61982230027503 0.0881651505946134 no 3043 0.0526352272316048 4535 315925
SGTC_1798 st045719 60.953 µM -1.62105368034717 0.0879969017448757 no 3044 0.0525030633395972 4531 3980186
SGTC_1378 2093-0007 380 nM -1.62309612908423 0.0877183611035187 no 3045 0.0522844284909751 4571 3618014
SGTC_76 0433-0009 400.328 µM -1.62367994194775 0.0876388641446254 no 3046 0.0522220670204333 4593 2841569
SGTC_670 4204-0025 119 µM -1.62382648312207 0.0876189182859734 no 3047 0.0522064231267164 4567 719039
SGTC_1553 gossypol 38.6 µM -1.62805296787335 0.0870451040950929 no 3048 0.0517568274902411 4491 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_806 3966-4455 5.86 µM -1.63137050233737 0.086596664538855 no 3049 0.0514060825788338 4544 714982
SGTC_1133 3473-0247 50 µM -1.63149346985297 0.0865800759603338 no 3050 0.0513931183164457 4528 711311
SGTC_2621 lithochol-11-enic acid 100 µM -1.63310236479537 0.0863632514306804 no 3051 0.0512237346678755 4508 6708711
SGTC_662 k832-1615 104 µM -1.63595589753001 0.0859796910196191 no 3052 0.0509244089447923 4591 5878478
SGTC_1330 1469-0054 61.8 µM -1.64362989723364 0.0849545078210043 no 3053 0.0501263372232587 4531 7102664
SGTC_943 3253-1379 105 µM -1.64535989746379 0.0847246649072623 no 3054 0.0499478072032929 4536 668464
SGTC_1168 k815-0004 80.5 µM -1.64628275019791 0.0846022481995183 no 3055 0.0498527796121154 4566 642433
SGTC_2157 5649910 96.377 µM -1.64872421175708 0.0842790273754283 no 3056 0.0496020738043077 4557 2858091
SGTC_659 k018-0002 107 µM -1.65208124405031 0.0838361101608041 no 3057 0.0492589949520472 4538 6797879 YHR007C ERG11
SGTC_2435 5706476 10.6 µM -1.65256480821716 0.0837724544092113 no 3058 0.0492097326161342 4561 5725375
SGTC_712 r015-0009 80.6 µM -1.65372415954573 0.0836199867978841 no 3059 0.0490917857601826 4603 6813872 YLR060W FRS1
SGTC_1282 0886-0010 32.4 µM -1.65536212081844 0.0834049321494021 no 3060 0.0489255324183194 4582 2836211 YNL267W PIK1
SGTC_701 4424-0219 185 µM -1.65868654250175 0.0829697337088361 no 3061 0.0485894862820166 4577 2911779
SGTC_1649 st011737 51.3 µM -1.65916393663223 0.0829073787873288 no 3062 0.0485413812192185 4585 1761035
SGTC_1650 st011916 45.8 µM -1.6593699194509 0.0828804851935177 no 3063 0.0485206369326753 4541 242528
SGTC_60 0986-0278 202 µM -1.6613879552512 0.0826173527967823 no 3064 0.0483177776401674 4522 3110598
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.66425566347151 0.0822445136109972 no 3065 0.048030674263893 4526 676296 Flavone; oxidizing agent.
SGTC_367 0335-0881 7.1 µM -1.66625153487284 0.0819857733536819 no 3066 0.0478316626841065 4497 23828853
SGTC_564 3555-0129 330 µM -1.66872943883974 0.0816653974858315 no 3067 0.0475855060720859 4490 563260
SGTC_1957 st077035 62.4 µM -1.67030710147128 0.0814619089391759 no 3068 0.0474293094348586 4600 705593
SGTC_1507 4075-3230 155 µM -1.67754048367758 0.080533833318249 no 3069 0.0467184199573931 4542 659771
SGTC_1355 1499-0035 1.68 µM -1.68423228513093 0.0796823780162246 no 3070 0.046068393057538 4583 1548538
SGTC_457 grayanotoxin iii 135 µM -1.6894061882772 0.0790287396916718 no 3071 0.0455708079563275 4381 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_929 2805-0021 398 µM -1.6898283438324 0.0789755869359755 no 3072 0.0455303997824571 4603 3098024
SGTC_2867 9039098 71.43 µM -1.69157617973878 0.0787558085452216 no 3073 0.0453634057110729 4568 6463460
SGTC_1346 1488-2224 62.4 µM -1.6956001743144 0.0782515808784593 no 3074 0.0449808123769176 4596 3722427
SGTC_769 0302-0231 76 µM -1.69593463428889 0.0782097817439266 no 3075 0.0449491298557692 4507 571869 YER009W NTF2
SGTC_971 1315-0384 26.7 µM -1.69961899547357 0.0777504488548556 no 3076 0.0446013074890634 4613 6769120
SGTC_1803 st050068 52.4 µM -1.70107441131678 0.0775695660218914 no 3077 0.0444645076102254 4607 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2840 9008771 71.43 µM -1.70721633198939 0.0768097502483255 no 3078 0.0438909252585521 4542 2992978
SGTC_1496 4469-0713 57.4 µM -1.70887852394779 0.0766050969332233 no 3079 0.043736726694843 4598 746691
SGTC_303 1348-1668 34.2 µM -1.70984304868289 0.0764865324859521 no 3080 0.0436474500542699 4604 5380509
SGTC_309 k408-0051 1.48 µM -1.71353754433506 0.0760336768602826 no 3081 0.043306846208896 4514 3640463
SGTC_950 1165-0508 94.1 µM -1.71648400728978 0.0756739774009993 no 3082 0.0430367463009451 4583 6148369
SGTC_586 0957-0265 8.15 µM -1.71774395455186 0.0755205613390813 no 3083 0.0429216641156889 4520 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1385 3091-4834 14.1 µM -1.71931679540701 0.0753293788783056 no 3084 0.0427783516862316 4584 4072814
SGTC_2270 7924575 90.91 µM -1.72122718587329 0.0750976629248912 no 3085 0.0426048032318085 4565 1262135
SGTC_1821 st053465 65.6 µM -1.7219018458934 0.0750159617525382 no 3086 0.0425436502756968 4621 675086
SGTC_865 0488-0499 301 µM -1.72648350614436 0.074462916136512 no 3087 0.0421302320589477 4542 9634651
SGTC_1760 st045453 10.4495 µM -1.72664324146041 0.0744436910193677 no 3088 0.0421158774783346 4602 3323419 YIL048W NEO1
SGTC_2959 9079155 11 µM -1.7282457142486 0.0742510333141228 no 3089 0.0419720905305309 4598 16189457
SGTC_555 4296-0685 37 µM -1.73949062559228 0.0729098061999313 no 3090 0.0409742498725958 4588 2908540 YHR072W ERG7
SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.74184228504208 0.0726316734068361 no 3091 0.0407680226492198 4628 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1281 0884-0031 11.8 µM -1.7425836847564 0.072544156106246 no 3092 0.0407031809841358 4617 1548255
SGTC_381 3461-2219 42.7 µM -1.7448443535141 0.0722777978402754 no 3093 0.0405059829309127 4580 2883159
SGTC_1809 st050081 57.6 µM -1.74594120386479 0.0721488342193777 no 3094 0.0404105845480172 4651 5036894
SGTC_82 0054-0107 293.755 µM -1.74801944337229 0.0719049662732893 no 3095 0.0402303303376839 4588 3104697
SGTC_3118 9124250 49.47 µM -1.74816269562005 0.0718881798648687 no 3096 0.0402179295831344 4582 1504786
SGTC_373 0844-0104 25.9 µM -1.75217233130604 0.0714195459499568 no 3097 0.0398720898907007 4614 5375804
SGTC_1699 st031318 29.054 µM -1.75223280305731 0.071412496187662 no 3098 0.0398668926342343 4658 5340658
SGTC_2164 5685496 200 µM -1.75336789634133 0.0712802667391361 no 3099 0.0397694389569627 4555 759046
SGTC_3324 9138759 60.749 µM -1.75378411887295 0.0712318272094021 no 3100 0.0397337526476156 4613 45595710
SGTC_1720 st037298 9.481 µM -1.75592401666289 0.0709831870870514 no 3101 0.0395506917613849 4588 597396
SGTC_759 3486-0358 89.3 µM -1.76034630489333 0.0704714631661524 no 3102 0.0391745537644355 4593 875103
SGTC_2710 st078562 53.7235 µM -1.76568856663057 0.0698570726298029 no 3103 0.0387240559962339 4605 17250908
SGTC_2823 7987624 58.44 µM -1.77416657315628 0.0688905263985688 no 3104 0.0380178007759223 4551 2239440
SGTC_2592 piperlongumine 83.33 µM -1.77520968462499 0.068772320853998 no 3105 0.0379316356168139 4597 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1884 5633444 25 µM -1.78041349985002 0.0681849585556538 no 3106 0.0375041570253932 4561 5724239
SGTC_1147 3809-1045 12.3 µM -1.7804980972483 0.0681754420078859 no 3107 0.0374972402231792 4636 325925
SGTC_1945 st075991 56.6 µM -1.78471296612352 0.0677025988828155 no 3108 0.0371539433477611 4602 1084980
SGTC_2593 nobiletin 86.24 µM -1.79250426747536 0.0668352102349523 no 3109 0.0365261131048241 4590 72344 An anti-infammatory.
SGTC_2208 7283366 200 µM -1.792635413569 0.0668206839523258 no 3110 0.0365156199820122 4626 898663
SGTC_2182 6325192 200 µM -1.79601981836031 0.0664466576142861 no 3111 0.0362456825868972 4644 736248
SGTC_1261 0712-0010 12.7 µM -1.80480140595217 0.0654837225591809 no 3112 0.0355528821608305 4615 2840123
SGTC_344 k064-0035 6.43 µM -1.80829055201132 0.0651041421009509 no 3113 0.0352806457813785 4567 5088750
SGTC_1990 st072050 59.8 µM -1.81264717851068 0.0646325890623346 no 3114 0.03494312812967 4622 17233948
SGTC_577 r071-0003 38.6 µM -1.81268858105764 0.0646281204877985 no 3115 0.0349399333393909 4605 4568517 YMR134W ERG29
SGTC_491 tetrandrine 80.3 µM -1.81363763384394 0.0645257550544034 no 3116 0.0348667662482225 4653 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1347 1493-0251 600 nM -1.81449164486101 0.0644337485937945 no 3117 0.0348010339521996 4661 3986378
SGTC_3155 9099265 49.47 µM -1.81821405380039 0.0640339066428754 no 3118 0.0345157114122161 4615 25236499
SGTC_2780 5215298 71.43 µM -1.82045426469393 0.0637942062503014 no 3119 0.0343449275407324 4639 2834131
SGTC_1258 0671-0043 57.1 µM -1.82358674964574 0.0634602044117539 no 3120 0.0341072856371483 4629 4298767
SGTC_2839 9003951 25.97 µM -1.82407211324308 0.0634085744227725 no 3121 0.0340705854120893 4675 2990634
SGTC_884 0851-0618 334 µM -1.82416783284519 0.0633983962221706 no 3122 0.0340633515162409 4649 9642473
SGTC_1054 3429-0080 167 µM -1.82480692361628 0.0633304720496187 no 3123 0.034015085346016 4629 1162877
SGTC_2507 purpurin 79.67 µM -1.82839028326229 0.0629506724189911 no 3124 0.0337454993118245 4620 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1304 1165-0502 251 µM -1.82905042779437 0.0628808977699375 no 3125 0.033696027094836 4630 767425
SGTC_2821 7996764 71.43 µM -1.82923644571701 0.0628612473016029 no 3126 0.033682097417261 4595 2987135
SGTC_1137 ixabepilone 100 µM -1.83718276567896 0.062026277222642 no 3127 0.0330914595103075 4592 154225 A novel microtubule stabilizer.
SGTC_1568 digitonin 820 nM -1.84171072187771 0.0615543814716504 no 3128 0.0327587375165192 4610 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1510 1123-0200 71.5 µM -1.84231177369741 0.0614919522444111 no 3129 0.0327147792833212 4634 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1225 1216-0074 20.6 µM -1.84260043200619 0.0614619878616269 no 3130 0.0326936854044881 4634 4241466
SGTC_2415 st077333 57.7 µM -1.84413518774824 0.06130286291908 no 3131 0.0325817204649376 4618 2766255
SGTC_524 r073-0010 27.8 µM -1.844681569744 0.0612462912665523 no 3132 0.0325419367076777 4595 2772106
SGTC_1986 st071812 45 µM -1.84479174474573 0.0612348888395634 no 3133 0.0325339193826617 4600 11838594
SGTC_2978 9011784 42.97 µM -1.84682924963041 0.0610243186177868 no 3134 0.0323859456272279 4618 2994934
SGTC_9 0092-0002 10.449 µM -1.84726403504133 0.0609794581692515 no 3135 0.0323544413463509 4644 759368
SGTC_255 tunicamycin 200.472 nM -1.85051468340186 0.0606448780193554 no 3136 0.0321197018551387 4567 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1941 st076221 61.8 µM -1.852735185442 0.0604171546262318 no 3137 0.031960162104683 4533 2828568
SGTC_3214 9129694 49.47 µM -1.85408175109989 0.0602793839751099 no 3138 0.0318637325393803 4620 17158655
SGTC_1567 st069303 68.4 µM -1.86028672719897 0.0596477114725244 no 3139 0.0314224851938409 4629 5581319
SGTC_1305 1181-0477 144 µM -1.86303218689058 0.0593698815511014 no 3140 0.0312288689492766 4669 6252086
SGTC_2057 5236571 38.335 µM -1.86742184175892 0.0589277745258675 no 3141 0.0309213510068223 4584 54684039 YBR257W POP4
SGTC_2038 4100038 30.985 µM -1.86893118154028 0.0587763585586664 no 3142 0.030816194732863 4621 3596803
SGTC_568 1193-0097 7.48 µM -1.87029935920078 0.0586393678849193 no 3143 0.0307211292459186 4459 3646150
SGTC_804 1595-0054 20.9 µM -1.87280152264474 0.0583894838007752 no 3144 0.0305478988273712 4651 761523 Stimulates phospholipase C.
SGTC_2571 chrysanthemic acid 100 µM -1.87519152752767 0.0581515823265473 no 3145 0.0303831896652803 4623 2743 An insecticide.
SGTC_2389 9091542 195.52 µM -1.8810092797359 0.0575756654499494 no 3146 0.0299853282605067 4623 3626624 YOL127W RPL25
SGTC_2671 danthron 100 µM -1.88188990767178 0.0574888816959559 no 3147 0.0299254825069203 4641 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2432 5630864 12.22 µM -1.8851319673127 0.0571702710264268 no 3148 0.0297060115398763 4639 5714970
SGTC_3199 9111318 49.47 µM -1.88755156436608 0.0569333941248004 no 3149 0.0295430888553053 4563 8548020
SGTC_3080 9117754 49.47 µM -1.88976417155838 0.0567174585118682 no 3150 0.0293947536603723 4645 9550191
SGTC_2537 larixol 68.93 µM -1.89500949008648 0.0562081281510314 no 3151 0.0290455722052242 4627 6708759
SGTC_1523 st012844 44.7 µM -1.8989229791889 0.0558304753064292 no 3152 0.0287873017567111 4669 4274103
SGTC_2612 dictamnine 15.46 µM -1.90507127469902 0.055241209494853 no 3153 0.02838540339553 4570 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_3107 9121808 49.47 µM -1.90683264492256 0.055073304335817 no 3154 0.0282711312675023 4624 662681
SGTC_3329 9141233 27.5565 µM -1.91688995203438 0.0541222883271282 no 3155 0.0276259569305983 4626 4909101 YNL103W MET4
SGTC_1114 scopoletin 1.73284 µM -1.91785812608446 0.0540314281248658 no 3156 0.0275645015223058 4700 5280460 A coumarin with genotoxic properties.
SGTC_2174 5790901 200 µM -1.93236892725297 0.0526840495799425 no 3157 0.0266569932133756 4635 786020
SGTC_1144 3486-0183 12.5 µM -1.93288366544988 0.0526367485013181 no 3158 0.0266252652723757 4669 6744069
SGTC_1498 4478-3555 97.6 µM -1.93654739304691 0.052301048785387 no 3159 0.0264003469580892 4679 3437919
SGTC_213 1246-0773 967 nM -1.93825481062638 0.0521451835274891 no 3160 0.0262960713358729 4684 6251622
SGTC_2314 7727897 200 µM -1.94041284646929 0.0519487107323689 no 3161 0.0261647682992656 4635 900724
SGTC_1774 st048371 48.465 µM -1.94126130889806 0.0518716259404833 no 3162 0.0261132950071818 4664 4242727
SGTC_346 4513-0042 7.16 µM -1.948697200778 0.0511999407490804 no 3163 0.0256657981404202 4634 2827372
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.95044864253108 0.0510427440873092 no 3164 0.0255613344947042 4627 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_902 1120-0002 2.07 µM -1.95751004721322 0.0504128565685045 no 3165 0.0251437658472887 4660 3280475
SGTC_1892 st058411 7.36 µM -1.9596799434322 0.0502205476654294 no 3166 0.0250166054239294 4668 3934738
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.96316079535121 0.0499132760558767 no 3167 0.0248137465938966 4562 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2188 6126565 140.678 µM -1.96421934635281 0.0498201305535961 no 3168 0.0247523300941063 4625 874518
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.97886845419179 0.0485452904371231 no 3169 0.0239154093971477 4654 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_320 4092-0846 5.34 µM -1.98085532004803 0.0483744100688666 no 3170 0.0238037504477827 4637 1359356
SGTC_1815 st051655 58.2 µM -1.98180016535793 0.0482933176241228 no 3171 0.0237508054824294 4663 5984156
SGTC_1212 0520-0165 585 µM -1.98267970512829 0.0482179278672044 no 3172 0.0237016089686318 4686 5403258
SGTC_1754 st042065 16.137 µM -1.99340230328694 0.0473063911478095 no 3173 0.0231087059372257 4463 1126236 YIL048W NEO1
SGTC_294 k038-0071 157 µM -2.00335005977026 0.0464731231412571 no 3174 0.0225698639041571 4704 24152826
SGTC_1112 tnp00069 1.16933 µM -2.00654118960789 0.046208329746952 no 3175 0.0223992693721027 4674 145826
SGTC_1411 3909-8223 150 µM -2.00763345180329 0.0461179748978043 no 3176 0.0223411285465728 4731 X1411
SGTC_2648 atorvastatin 78.68 µM -2.00809132313633 0.0460801407933473 no 3177 0.022316794072717 4701 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2602 kawain 100 µM -2.01642820569887 0.0453956103816933 no 3178 0.0218776092866843 4655 5369129
SGTC_2687 chenodiol 100 µM -2.01758272655602 0.0453014622697734 no 3179 0.0218173686708409 4697 5702181 A cholesterol synthesis inhibitor.
SGTC_1215 3852-0577 11.2 µM -2.02202877928178 0.0449403646910284 no 3180 0.021586689397856 4695 2884876
SGTC_2894 9048625 32.47 µM -2.0234716664771 0.0448236761344506 no 3181 0.0215122709486059 4691 4092861
SGTC_2614 arthonioic acid 13.39 µM -2.02669123036495 0.0445641843538802 no 3182 0.0213469999470034 4579 6710684
SGTC_3082 9117008 49.47 µM -2.02845999788069 0.0444221403281786 no 3183 0.0212566609975738 4699 41448529
SGTC_2068 5226020 147 µM -2.02958356851874 0.0443320996166514 no 3184 0.0211994432630047 4696 1810509
SGTC_2170 morpholine 200 µM -2.03027546889693 0.0442767253136254 no 3185 0.0211642731525633 4708 121171 Reacts with secondary amines.
SGTC_304 1310-0298 97 µM -2.03374645873645 0.0439997751697559 no 3186 0.0209885826660327 4447 1550234
SGTC_2586 curcumin 80 µM -2.03986080229122 0.0435153110534771 no 3187 0.0206820959084756 4598 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2736 butenafine 14.65 µM -2.0515265558342 0.0426029343655099 no 3188 0.0201078481186399 4657 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2723 salbutamol 83.58 µM -2.05258622786936 0.0425208296508113 no 3189 0.0200563621849674 4692 9884233 β2-adrenoceptor agonist
SGTC_1324 1418-0026 34.4 µM -2.07233035025179 0.0410143004424353 no 3190 0.0191173219347017 4715 1372513
SGTC_2315 7733312 200 µM -2.07581419548942 0.0407530217630257 no 3191 0.0189555694724069 4634 726316
SGTC_3129 9127257 49.47 µM -2.08742719311467 0.0398918193416504 no 3192 0.0184247680014853 4650 837894
SGTC_1827 berberine 7.24 µM -2.09524199694768 0.0393206554971796 no 3193 0.0180747428551638 4634 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_256 clotrimazole 625 nM -2.09690279870788 0.03920013323499 no 3194 0.0180010903717729 4659 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_302 1094-0063 18.9 µM -2.09862182429123 0.0390757025805029 no 3195 0.0179251254699349 4716 5440289
SGTC_3064 1327-0027 10 µM -2.11580130328336 0.0378497574838036 no 3196 0.017180855111437 4701 16000455 YPR107C YTH1
SGTC_1239 0337-0584 35.4 µM -2.11715004492508 0.037754853792681 no 3197 0.0171235577593946 4717 914301 YML130C ERO1
SGTC_944 3370-0224 231 µM -2.12955205359051 0.0368912646599848 no 3198 0.0166043065246111 4687 4580514
SGTC_2464 5717415 7.67 µM -2.13026131583583 0.0368423688879279 no 3199 0.0165750226902101 4679 5285744
SGTC_2417 cerulenin 830 nM -2.13367984942426 0.036607441583512 no 3200 0.0164344983275714 4701 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2551 apiole 73.87 µM -2.13871735152903 0.0362634908907601 no 3201 0.0162292832417527 4681 10659 A possible DNA adduct former.
SGTC_1780 st038448 24.544 µM -2.1482282454305 0.0356213193256752 no 3202 0.0158478139543688 4706 728868 YDL195W SEC31
SGTC_1359 1582-0056 520 nM -2.15099763003618 0.0354360937525292 no 3203 0.015738193372975 4741 3661189
SGTC_3060 1327-0027 12.5 µM -2.15584852999972 0.0351135532086263 no 3204 0.0155477472989687 4660 16000455 YPR107C YTH1
SGTC_1268 0828-0275 2.46 µM -2.163212857174 0.0346285005354922 no 3205 0.0152624059134402 4740 745337
SGTC_1139 k015-0024 46.9 µM -2.16443855831636 0.0345483062318987 no 3206 0.0152153536406416 4735 2766652
SGTC_2912 7964298 10.93 µM -2.17129708375496 0.0341023821681077 no 3207 0.0149543613105638 4703 2975850
SGTC_293 4049-0273 38.5 µM -2.17937262028427 0.0335834088722551 no 3208 0.0146519992009018 4639 1380311
SGTC_2030 5175110 200 µM -2.18326310264519 0.0333357175932834 no 3209 0.0145082200483184 4724 2831986
SGTC_3100 9120536 49.47 µM -2.20696710891631 0.0318588916499431 no 3210 0.0136581786514457 4675 16421196
SGTC_1571 st070080 73.4 µM -2.20810855368865 0.0317891625533028 no 3211 0.0136183534417228 4711 4315245
SGTC_1656 st012921 11 µM -2.21090824878172 0.031618667257807 no 3212 0.013521095675081 4652 6732821
SGTC_172 1112-0046 2.638 µM -2.21522677207035 0.0313571610496816 no 3213 0.0133722515848004 4713 2802135 YIL048W NEO1
SGTC_1733 st037357 54.9 µM -2.23632751327732 0.0301050066244378 no 3214 0.0126651627405997 4680 1272339 YGL099W LSG1
SGTC_617 3770-0098 35 µM -2.24694685402405 0.0294906892886564 no 3215 0.0123217119084497 4691 5962639
SGTC_3132 9126706 49.47 µM -2.2500115557396 0.0293153470421395 no 3216 0.0122241058846612 4728 850858
SGTC_2989 9073649 71.4286 µM -2.2558327750499 0.0289846787506059 no 3217 0.0120405529493001 4687 21367202
SGTC_340 k038-0059 454 µM -2.25619004605731 0.0289644857098394 no 3218 0.0120293658377138 4738 23733424
SGTC_1829 berberine 14.4 µM -2.27244379038675 0.0280581104690028 no 3219 0.0115298596807612 4679 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_887 0885-0007 9.62 µM -2.27489228251826 0.0279236414875502 no 3220 0.0114561962124082 4741 5719458
SGTC_1012 4112-3522 18 µM -2.27793299324691 0.0277573960678556 no 3221 0.0113652850867337 4733 3112398
SGTC_2291 7917025 104.35 µM -2.27890831459746 0.0277042471264463 no 3222 0.0113362580324389 4678 2964612
SGTC_2116 5511452 16.8835 µM -2.27951284208306 0.0276713467363121 no 3223 0.0113182987297238 4744 870744
SGTC_2327 6189656 200 µM -2.28508627013532 0.0273695535686055 no 3224 0.0111538848549866 4745 5349088
SGTC_877 0771-0151 33.1 µM -2.29868347663078 0.0266447855172514 no 3225 0.0107614597370636 4753 6166523
SGTC_217 ketoconazole 989 nM -2.30255287045088 0.0264414908988511 no 3226 0.0106520067305635 4594 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_543 3844-1095 191 µM -2.30468757366751 0.0263298913293842 no 3227 0.0105920386681036 4743 4230703
SGTC_2007 4011539 71.82 µM -2.30630081531487 0.02624581454288 no 3228 0.0105469148116941 4726 45595301
SGTC_3170 9103054 49.47 µM -2.31199805322103 0.0259506874438038 no 3229 0.0103888952980633 4713 16432970
SGTC_1814 st052110 31.539 µM -2.3137893763472 0.0258584693761122 no 3230 0.0103396391997884 4712 674163
SGTC_1800 st050079 29.0735 µM -2.31494872073932 0.0257989321255009 no 3231 0.0103078692899778 4615 3645560
SGTC_1216 1165-0504 9.65 µM -2.31763616477226 0.0256613615497826 no 3232 0.0102345514994768 4749 6304004
SGTC_3136 9095672 49.47 µM -2.32539247504266 0.0252677548266556 no 3233 0.0100254917444444 4668 17217380
SGTC_2440 5628896 157.78 µM -2.33267543568136 0.0249027862713147 no 3234 0.00983259319464544 4731 5522048
SGTC_893 0958-0369 48.9 µM -2.33423477490712 0.0248252209041058 no 3235 0.00979171597257953 4606 6819948
SGTC_955 1216-0110 33 µM -2.34066334913774 0.0245075841978852 no 3236 0.00962475782800192 4717 3619719
SGTC_1299 1079-1439 3.74 µM -2.3451568457949 0.0242875912080261 no 3237 0.00950953846400358 4752 323161
SGTC_1962 st076595 64.5 µM -2.34781572331278 0.0241582003115451 no 3238 0.00944193067629039 4728 279619
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -2.3483311978774 0.0241331825229412 no 3239 0.00942887236267403 4729 1377
SGTC_2679 rapamycin 1 nM -2.35610339903632 0.023758600706587 no 3240 0.00923388817644034 4614 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_551 k048-0028 34.9 µM -2.35749946537901 0.0236918377405485 no 3241 0.00919924089908875 4715 6836383
SGTC_313 3474-0040 5.03 µM -2.36243902799028 0.0234568822198445 no 3242 0.00907756380626981 4746 1043375 YIL048W NEO1
SGTC_866 0495-0101 262 µM -2.37357685623834 0.0229342859215742 no 3243 0.00880836315466684 4744 635694
SGTC_2399 5884133 200 µM -2.37958607905875 0.0226564247121519 no 3244 0.00866604722700303 4697 722445
SGTC_425 3825-7017 13.1 µM -2.39386485491662 0.0220075501435073 no 3245 0.00833594524479537 4740 3397440
SGTC_1286 0929-0070 131 µM -2.39937963365079 0.0217611750621719 no 3246 0.00821143908420041 4766 1420408
SGTC_3175 9106517 49.47 µM -2.40237649749978 0.0216282687414479 no 3247 0.00814446691527336 4750 41468073
SGTC_612 0302-0167 22.4 µM -2.40823013879948 0.0213706464125165 no 3248 0.00801503623324683 4741 235821
SGTC_528 3492-0019 172 µM -2.42035473799845 0.0208452806955153 no 3249 0.00775268643674283 4749 2869262
SGTC_1377 2944-0135 198 µM -2.42633911813948 0.0205900305238032 no 3250 0.00762600550019448 4742 1894137
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -2.42826045712581 0.0205086437171489 no 3251 0.00758572176878363 4739 442882
SGTC_2245 6637752 200 µM -2.44230174780564 0.0199220980969149 no 3252 0.0072969713972537 4756 681890
SGTC_2449 5812982 45.77 µM -2.47439343272696 0.0186347788926046 no 3253 0.00667313155661799 4713 776185
SGTC_3211 9128781 49.47 µM -2.5046989058252 0.0174848073010185 no 3254 0.00612778367899379 4686 17194361
SGTC_2136 5328288 199.296 µM -2.51106817248742 0.0172509813991061 no 3255 0.00601832248398909 4738 262395
SGTC_2273 7815444 169.05 µM -2.51521360924512 0.0171002352752706 no 3256 0.00594801416437748 4720 2824616
SGTC_1121 fusaric acid 630.51 nM -2.52986448789616 0.0165764531768745 no 3257 0.00570532938535452 4747 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1170 0310-0127 64.8 µM -2.56370538235904 0.0154188546604324 no 3258 0.00517807047980289 4762 774975
SGTC_2328 6201408 200 µM -2.57465419292013 0.0150595025917268 no 3259 0.00501701753587056 4732 2890418
SGTC_1396 3511-0007 98.6 µM -2.58910711581386 0.0145961806746224 no 3260 0.00481125785826706 4768 X1396
SGTC_29 0299-0004 12.984 µM -2.5902450438005 0.0145602283364911 no 3261 0.00479538175550703 4736 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2582 agaric acid 100 µM -2.61150077357536 0.0139025374466408 no 3262 0.00450728919717799 4530 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_875 0709-0210 25.7 µM -2.62214103043507 0.013583040852534 no 3263 0.00436896320811974 4771 6251364
SGTC_1718 roemerine 11.9335 µM -2.63749385357989 0.0131332165520433 no 3264 0.00417605695567073 4498 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3059 1327-0034 3 µM -2.63979554699831 0.0130669010001601 no 3265 0.00414780280832112 4698 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3081 9117243 49.47 µM -2.65444224903131 0.0126516491108549 no 3266 0.00397198181332997 4740 45595589
SGTC_1064 honokiol 6.76 µM -2.65580381694986 0.0126136336288575 no 3267 0.00395598139336179 4779 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_374 0880-0231 82.3 µM -2.66012680774556 0.0124935886929563 no 3268 0.00390556183593519 4696 6833587
SGTC_158 k038-0087 26.446 µM -2.66987427992338 0.0122265361074709 no 3269 0.00379398260367056 4721 X158
SGTC_1712 st032288 53.4 µM -2.68527156613362 0.0118147729481688 no 3270 0.00362354477629473 4661 2883011
SGTC_2436 5633522 8.09 µM -2.69931278979936 0.0114498184806716 no 3271 0.00347414182313926 4763 5724242
SGTC_252 miconazole 1.30953 nM -2.70022434251057 0.0114264679632075 no 3272 0.00346463665228808 4740 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1951 sophoraflavanone G 9.2 µM -2.71399770158957 0.0110786495211047 no 3273 0.00332383137140568 4738 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1558 st069300 45.6 µM -2.732079846099 0.0106360253006281 no 3274 0.00314679432456066 4776 24208000
SGTC_488 nitrendipine 139 µM -2.73947954016358 0.0104593814783636 no 3275 0.00307682723852576 4773 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1022 4477-0945 21.3 µM -2.74920497129373 0.0102311100897511 no 3276 0.00298700078647462 4748 4648966
SGTC_922 1866-0035 480 µM -2.74923193441856 0.0102304833106332 no 3277 0.00298675506814444 4740 3156169
SGTC_3133 9127736 49.47 µM -2.7585224914576 0.0100165008863609 no 3278 0.00290316547034491 4770 27243420
SGTC_562 3772-2733 112 µM -2.77288450271498 0.0096933979967688 no 3279 0.00277809184248669 4755 2876874 YIL048W NEO1
SGTC_1088 bifonazole 369 nM -2.79119062133545 0.00929479173470607 no 3280 0.00262572672848315 4783 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1310 1188-0297 994 nM -2.80260854742544 0.00905350012838565 no 3281 0.00253455774480281 4742 1588352
SGTC_743 1275-0778 158 µM -2.80746900725042 0.00895246153936332 no 3282 0.00249662421991164 4780 2849257 YMR203W TOM40
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -2.81029384049415 0.00889419433201754 no 3283 0.00247481438645799 4790 688664
SGTC_1859 st055998 20 µM -2.82543693945948 0.00858747241100309 no 3284 0.00236080904596787 4757 676301
SGTC_3063 1327-0034 4 µM -2.83216678580434 0.00845416502396997 no 3285 0.00231168629523439 4715 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3131 9127911 49.47 µM -2.84034185063038 0.00829467605712206 no 3286 0.00225326060295319 4759 45595681
SGTC_2752 diclazuril 33.15 µM -2.84598946861254 0.00818604453932285 no 3287 0.00221368295410564 4739 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2981 9013952 38.96 µM -2.85958631375606 0.00792962245422104 no 3288 0.00212096981991725 4746 2996344
SGTC_2115 tiliquinol 12.7705 µM -2.86919297522124 0.00775273534851656 no 3289 0.00205760320191897 4769 71208 A bioactive hydroxyquinoline.
SGTC_2322 7413319 38.22 µM -2.89403965914236 0.00731124282168382 no 3290 0.00190160061221891 4750 1840400
SGTC_453 enantio-paf c16 10 µM -2.89744323116562 0.00725252519638865 no 3291 0.00188108909534477 4389 13871343 A lipid and platelet activating factor
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -2.9163478175304 0.0069338961209334 no 3292 0.00177077723569104 4773 6710655
SGTC_2963 9082507 9 µM -2.91721964162537 0.00691950473129586 no 3293 0.00176583491142571 4768 16459611
SGTC_813 k007-0158 173 µM -2.93471607583391 0.00663621045870275 no 3294 0.00166926508527764 4786 6523916
SGTC_2640 pentamidine 10.38 µM -2.93837933108126 0.00657821168393094 no 3295 0.00164966533226194 4769 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_268 camptothecin 39.6153 µM -2.98738499245587 0.00584433508326806 no 3296 0.00140687569608488 4768 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1161 k007-0610 110 µM -2.99767734274548 0.00569976974219144 no 3297 0.00136022763361703 4752 5843850
SGTC_339 3091-4833 71.4 µM -3.00379702052141 0.005615326222942 no 3298 0.00133316573283168 4694 3240077
SGTC_2541 muurolladie-3-one 83.07 µM -3.0231559394948 0.00535546807605924 no 3299 0.00125076651681624 4779 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1658 st012944 20 µM -3.06296929150694 0.0048544076230468 no 3300 0.00109576273924813 4729 24207260
SGTC_2980 9014342 25.29 µM -3.07591718369739 0.00470070545206136 no 3301 0.00104928062091584 4776 2996599
SGTC_825 1988-2224 89.6 µM -3.08613995116119 0.00458243540202507 no 3302 0.00101386678650598 4790 1180859
SGTC_3108 9121785 49.47 µM -3.1006392266078 0.00441924446828321 no 3303 0.000965517043359241 4765 17140271
SGTC_1283 0922-0125 16.4 µM -3.1114680948621 0.00430077204011705 no 3304 0.000930797946400421 4791 3360884
SGTC_1202 1988-0068 29.6 µM -3.13507531779422 0.0040522884471847 no 3305 0.000859049968468007 4788 2850480
SGTC_2271 7849410 118.62 µM -3.14099652462405 0.00399201481854043 no 3306 0.000841870152002418 4774 972430
SGTC_1547 harmine 94.2 µM -3.14182815765698 0.00398361399974859 no 3307 0.00083948272253342 4750 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1856 st057054 55.7 µM -3.15018502110084 0.00390007113888545 no 3308 0.00081583546669142 4787 1266018
SGTC_1211 1056-0033 32.3 µM -3.1846028839527 0.00357230267012242 no 3309 0.000724763870283389 4800 6741922
SGTC_2858 9025781 8.96 µM -3.20999359723956 0.00334658454514905 no 3310 0.000663689644859322 4714 4894980 YPL153C RAD53
SGTC_2482 5981709 142.65 µM -3.2224020644751 0.0032410103059734 no 3311 0.000635603074825839 4778 877755
SGTC_1560 lithocholic acid 53.1 µM -3.2234167244251 0.00323251128295885 no 3312 0.00063335562042622 4790 9903 A bile acid which acts as a detergent.
SGTC_3197 9113331 49.47 µM -3.26916890152622 0.00286950622028899 no 3313 0.000539319467588389 4770 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2815 7968870 71.43 µM -3.28489586318075 0.00275348692379366 no 3314 0.000510100355051491 4776 2977326 YHR190W ERG9
SGTC_1731 st035964 63 µM -3.30910760487262 0.00258313538517434 no 3315 0.000467969292240198 4768 6739575
SGTC_2651 TUB2.036 5 µM -3.3286933783756 0.0024523643151445 no 3316 0.000436272038715756 4732 15992207 YFL037W TUB2
SGTC_2718 lomofungin 53.02 µM -3.33012875261539 0.00244302022296625 no 3317 0.000434029173417419 4794 5351222 A RNA synthesis inhibitor.
SGTC_2976 9009005 19.48 µM -3.44037693110932 0.00181458982718617 no 3318 0.000290452277993257 4797 2993148
SGTC_1818 st052136 56.3 µM -3.44051950514128 0.00181388246951265 no 3319 0.000290299293560194 4720 674169
SGTC_3345 9148410 3.559 µM -3.44597687096597 0.00178699442742848 no 3320 0.000284499528564065 4787 4903596
SGTC_2777 climbazole 1.536 µM -3.47427591539496 0.00165329338861917 no 3321 0.000256117006231546 4711 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1844 rapamycin 4 nM -3.48577701552508 0.00160160956498333 no 3322 0.000245354929139502 4725 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1072 oxiconazole 14.9 nM -3.53730974458586 0.0013876337293758 no 3323 0.000202112649887479 4792 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2485 5633444 17.78 µM -3.65802511779239 0.000984715656646372 yes 3324 0.000127083071638163 4798 5724239
SGTC_2534 helenine 20.12 µM -3.66230826063211 0.000972626838196041 yes 3325 0.000124976412862427 4799 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_3266 9136860 49.47 µM -3.69524717472551 0.00088411561574196 yes 3326 0.000109836488390123 4717 4871271 YPR165W RHO1
SGTC_1707 st032323 6.317 µM -3.7433610983455 0.000768075431506355 yes 3327 9.07874978018484e-05 4752 3132057 YMR211W DML1
SGTC_178 4092-0806 87.505 µM -3.79324753704499 0.000662708225477242 yes 3328 7.43448991014416e-05 4781 2169044
SGTC_1556 plumbagin 1.48 µM -4.02996482860123 0.00032148118636019 yes 3329 2.7892599589261e-05 4803 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2021 4019055 173 µM -4.10715920640432 0.000251819607135905 yes 3330 2.00277573576629e-05 4774 44827708 YER133W GLC7
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -4.42802998227668 8.73104183760148e-05 yes 3331 4.75488423810868e-06 4798 6728940
SGTC_2549 cedrol 20.94 µM -4.47154854532694 7.52126766511443e-05 yes 3332 3.88276133703727e-06 4806 6708665 A sedative which affects the nervous system.
SGTC_431 k089-0097 107 µM -4.69023345124323 3.48449864570489e-05 yes 3333 1.36446757230804e-06 4737 5499420
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -4.69253773839381 3.45575075175226e-05 yes 3334 1.34918369289883e-06 4810 4000243
SGTC_514 4466-0038 2.65 nM -4.90036916710641 1.61221529244407e-05 yes 3335 4.78283706399572e-07 4794 5722064
SGTC_1787 fluconazole 80 µM -5.17977326523182 5.51578131265102e-06 yes 3336 1.11077877981447e-07 4742 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2409 alverine citrate 63.97 µM -5.48995418659375 1.57259753591565e-06 yes 3337 2.01019004880954e-08 4804 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_151 3013-0144 2.285 µM -5.49546446851715 1.53698739456207e-06 yes 3338 1.94841700881094e-08 4790 906558 YHR107C CDC12
SGTC_2561 acetosyringone 100 µM -5.91901544376554 2.47875358515969e-07 yes 3339 1.61937277902279e-09 4808 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_513 4245-1575 41.7 µM -7.55620838676668 6.47533181419923e-11 yes 3340 2.07494399540635e-14 4809 719745
SGTC_2896 9052656 71.43 µM -8.35108691630908 5.91371630644441e-13 yes 3341 3.38188117662511e-17 4784 6469436