SGTCid condition conc unit SSN8|YNL025C.score SSN8|YNL025C.strain.pval SSN8|YNL025C.strain.significant SSN8|YNL025C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_187 1488-2104 32.728 µM 8.61741307089707 1.14555035869995e-15 yes 1 3.42418598695855e-18 6 2852859
SGTC_1330 1469-0054 61.8 µM 7.51355775605018 2.41332536487291e-12 yes 2 2.87708695208313e-14 1 7102664
SGTC_2950 9072895 21.46 µM 7.01028645323087 5.65455037261499e-11 yes 3 1.18915342659435e-12 5 17332245
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 6.51407067796297 1.03286212735004e-09 yes 4 3.65705273630625e-11 7 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_872 0588-0139 234 µM 6.13247648413999 8.40148168741705e-09 yes 5 4.32607507360122e-10 7 2047100
SGTC_1335 1486-0900 202 µM 5.80051672068591 4.72088785360087e-08 yes 6 3.30554405428798e-09 11 X1335
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 5.79753899291905 4.79259571660319e-08 yes 7 3.36475686003653e-09 35 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1047 2043-3044 82 µM 5.74966684010874 6.10090400772226e-08 yes 8 4.4709737810507e-09 10 669592
SGTC_445 e6 berbamine 66 µM 5.41060944460325 3.19532272459008e-07 yes 9 3.14053110376628e-08 44 6610268 A calcium/calmodulin antagonist.
SGTC_1841 st054148 70 µM 5.33346511264192 4.5966347856628e-07 yes 10 4.81780413864753e-08 2 675442
SGTC_1597 7-benzyloxygramine 47.5 µM 5.24647294871689 6.88648609214279e-07 yes 11 7.75193002135082e-08 61 260807
SGTC_770 0389-1121 67.2 µM 5.20773633744159 8.22829817999175e-07 yes 12 9.55791422847872e-08 8 6753108
SGTC_2499 avocadenofuran 51.48 µM 5.12661908529684 1.18984198898334e-06 yes 13 1.47495748312801e-07 14 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1588 farnesol 29.9 µM 4.98387866021395 2.24756242602016e-06 yes 14 3.11610853016047e-07 2 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1511 0906-3109 28.5 µM 4.94778734049369 2.63278303345556e-06 yes 15 3.75309250459088e-07 22 2882180
SGTC_1729 st035615 45.989 µM 4.92962248826901 2.84983641471139e-06 yes 16 4.11943332114089e-07 18 17385451
SGTC_1959 st077091 55.8 µM 4.91354761124967 3.05611250378193e-06 yes 17 4.47214997197612e-07 24 821356 YKL052C ASK1
SGTC_1730 st033808 45.1 µM 4.83980284448748 4.19984456342314e-06 yes 18 6.49839992820615e-07 13 1045166
SGTC_1666 st014829 29 µM 4.80123445221254 4.95083018229683e-06 yes 19 7.88452577845231e-07 17 3858230
SGTC_2771 fluoxetine 41.05 µM 4.69755683454933 7.65842382287971e-06 yes 20 1.31645966944529e-06 10 3386 A selective serotonin reuptake inhibitor.
SGTC_176 1486-1328 72.834 µM 4.5934210451666 1.17662347020575e-05 yes 21 2.18019020190444e-06 41 22310231
SGTC_2489 cantharidin 73.42 µM 4.55776711999346 1.36024246220183e-05 yes 22 2.58501578743448e-06 27 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1402 3909-7673 35.9 µM 4.53805825540277 1.47312186202484e-05 yes 23 2.83872890783796e-06 11 5328014
SGTC_1199 1638-0010 4.46 µM 4.35770673356487 3.01123201054267e-05 yes 24 6.57161658965279e-06 11 3111136
SGTC_1712 st032288 53.4 µM 4.30294803132008 3.72194581275337e-05 yes 25 8.42701968009558e-06 166 2883011
SGTC_2249 haloperidol 116.36 µM 4.23349620286425 4.85269868862398e-05 yes 26 1.15043034550952e-05 93 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_262 fenpropimorph 62.5 µM 4.14756308689651 6.70208875426907e-05 yes 27 1.68016445905774e-05 23 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1145 3546-0597 10.2 µM 4.10775360775286 7.76784352182043e-05 yes 28 1.99762990112165e-05 17 875334
SGTC_2540 epiandrosterone 100 µM 4.06122497464715 9.21530219933129e-05 yes 29 2.44079507933513e-05 56 441302 A steroid.
SGTC_2178 5812956 200 µM 4.02871953281542 0.000103730522644405 yes 30 2.8040737976421e-05 17 5403383
SGTC_2373 9071805 200 µM 4.00327162764383 0.000113733458820118 yes 31 3.1236252400246e-05 11 10149009
SGTC_1573 oleylamine 1.06 µM 3.99999984382769 0.000115083298202646 yes 32 3.16712627337026e-05 27 5356789 An amine of the fatty acid oleic acid.
SGTC_1436 4092-1007 8.32 µM 3.98796198655884 0.000120180283873184 yes 33 3.33216693679991e-05 11 2881121
SGTC_2496 diffractaic acid 79.83 µM 3.9584382787906 0.00013359187969837 yes 34 3.77207150667143e-05 18 94870 An apoptosis inducer which activates caspases.
SGTC_2561 acetosyringone 100 µM 3.95797535395132 0.000133812932760426 yes 35 3.77938774195326e-05 24 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1022 4477-0945 21.3 µM 3.90986676241046 0.00015874969152252 yes 36 4.61735218944865e-05 24 4648966
SGTC_649 1123-0311 367 µM 3.90763940783732 0.00016000350601147 yes 37 4.66011330327963e-05 72 693629 YIL048W NEO1
SGTC_1572 epiandrosterone 68.9 µM 3.89020762727692 0.000170141130130292 yes 38 5.00792437747385e-05 27 441302 A steroid.
SGTC_1877 wortmannin 25 µM 3.87519496986469 0.000179350368336768 yes 39 5.32696807999768e-05 98 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2921 7974240 10.71 µM 3.8432253294773 0.000200536401080667 yes 40 6.07139428020128e-05 62 2979074 YDR527W RBA50
SGTC_831 k061-1017 217 µM 3.80940533618456 0.000225478932121441 yes 41 6.96507138416676e-05 71 1240153
SGTC_2369 9071472 200 µM 3.7823245130187 0.000247507602245867 yes 42 7.76853121630486e-05 20 17296037
SGTC_2688 kanamycin b 96.69 µM 3.68357973706559 0.000345983712333365 yes 43 0.00011499064918747 410 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_582 0987-0078 156 µM 3.66064183567786 0.000373564618530169 yes 44 0.000125792119095729 85 1625765
SGTC_2382 9035899 200 µM 3.59259678394231 0.000467858069665335 yes 45 0.000163699496401329 23 6462679
SGTC_1725 st036284 20.55 µM 3.5217060499639 0.000589192749630829 yes 46 0.000214389651167098 47 707914
SGTC_2985 9022375 71.43 µM 3.49371203938207 0.000644655638076082 yes 47 0.000238177265015685 47 4939335
SGTC_2618 avocadyne 43.43 µM 3.43883856685326 0.000767597582873728 yes 48 0.000292107750980485 50 3015189
SGTC_126 0417-1624 672.48 µM 3.42582086908177 0.000799771171272657 yes 49 0.000306472238532941 52 41912 YDL195W SEC31
SGTC_1992 st073643 23.3 µM 3.42466711793332 0.000802681770865386 yes 50 0.000307776566102682 19 3161292
SGTC_1671 st016596 74.5 µM 3.34801479727833 0.00101938670183018 no 51 0.000406963327108341 29 2829167
SGTC_2895 9054447 58.44 µM 3.31838160425251 0.0011166768330001 no 52 0.000452703483876217 21 2697450
SGTC_258 haloperidol 50.781 µM 3.30138519881112 0.00117624741006492 no 53 0.000481043488016269 50 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1832 st054113 55 µM 3.26286600255343 0.00132217067276953 no 54 0.000551458273615212 15 1251267
SGTC_308 4092-1169 104 µM 3.25571030375909 0.00135103582884852 no 55 0.000565545475493491 83 2268590 YDL196W YDL196W
SGTC_2029 5175081 200 µM 3.23847789637255 0.00142292735701712 no 56 0.000600846660747103 49 1380876
SGTC_88 0180-0332 8.668 µM 3.23835736606194 0.00142344226907358 no 57 0.000601100586937564 47 3101745
SGTC_319 1348-1596 45.5 µM 3.23451199879834 0.00143995944895868 no 58 0.000609254002867583 39 5380505
SGTC_2938 9059746 27.26 µM 3.22004291532023 0.00150368885408935 no 59 0.000640857038523908 65 6471769
SGTC_1987 st072290 61.9 µM 3.21431480468536 0.00152962163879011 no 60 0.000653781158929596 41 54697379
SGTC_2834 9001755 58.44 µM 3.20427246648039 0.00157607245586717 no 61 0.000677021345934855 65 2989575
SGTC_2115 tiliquinol 12.7705 µM 3.20128128589885 0.00159015462679671 no 62 0.000684089493912554 26 71208 A bioactive hydroxyquinoline.
SGTC_2430 5571206 200 µM 3.17833383662128 0.00170206193900939 no 63 0.000740620467176491 94 1731771
SGTC_2571 chrysanthemic acid 100 µM 3.14547926864624 0.00187478557868468 no 64 0.000829074731837135 54 2743 An insecticide.
SGTC_3073 9114972 49.47 µM 3.14359365834243 0.00188516606555008 no 65 0.000834435004343323 34 41905075
SGTC_2313 7726885 200 µM 3.13333567156206 0.00194255798770959 no 66 0.000864158324285679 64 726423
SGTC_2384 9036245 200 µM 3.13250056654226 0.00194729943647874 no 67 0.000866620465150602 62 6462766
SGTC_451 chloral hydrate 100 µM 3.12508597983688 0.00198986026419661 no 68 0.000888765480762356 100 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2639 lactacystin 53 µM 3.12460718346303 0.00199263744454074 no 69 0.000890213220981683 66 3870 A proteasome inhibitor.
SGTC_2781 5567276 71.43 µM 3.11040024182572 0.0020766609246927 no 70 0.000934169965090632 107 2853274
SGTC_898 1000-0849 28.3 µM 3.09840649758255 0.00215008345012254 no 71 0.000972821773937083 29 6751807
SGTC_227 fluconazole 33.516 µM 3.09427899964972 0.00217589024335921 no 72 0.000986459296818098 136 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1960 st011366 51.8 µM 3.08837252005742 0.00221330850270356 no 73 0.00100628009284088 32 3972846
SGTC_2932 9016711 44.54 µM 3.08494855624564 0.0022352658032271 no 74 0.00101793681661613 94 7117328
SGTC_2377 9073351 62.6 µM 3.07540005103135 0.00229754538489696 no 75 0.00105110187085441 64 7337946 YHR072W ERG7
SGTC_1407 3909-7909 12.3 µM 3.066546637807 0.00235669094953242 no 76 0.00108273511821158 50 4411780
SGTC_2734 clemastine 41.6 µM 3.06592081312147 0.00236092350141652 no 77 0.00108500388688826 8 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2293 7624732 200 µM 3.05977723227613 0.00240284030980797 no 78 0.00110750839455677 61 894453
SGTC_1052 3253-3998 198 µM 3.04767388035928 0.00248739563010464 no 79 0.00115310029623385 67 5450317
SGTC_1801 st050089 28.441 µM 3.04697979340628 0.00249232520411059 no 80 0.00115576624086467 188 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2256 7954252 200 µM 3.04372055742931 0.00251559143407745 no 81 0.00116836041538702 25 2972920
SGTC_1853 st056710 91.2 µM 3.03607164875848 0.00257096662092929 no 82 0.00119841200794273 66 269167
SGTC_380 3970-0968 6 µM 3.03465808675879 0.00258132006147657 no 83 0.00120404257551452 48 2891601
SGTC_56 0957-0365 83.25 µM 2.98214484497359 0.00299367790210141 no 84 0.00143118270223904 102 6752360
SGTC_1482 3346-2049 8.48 µM 2.97618973979246 0.00304400396880731 no 85 0.00145927114971825 68 3826804
SGTC_1760 st045453 10.4495 µM 2.96939547681902 0.00310235137317446 no 86 0.00149193152082398 195 3323419 YIL048W NEO1
SGTC_2823 7987624 58.44 µM 2.93921128511283 0.00337392547276095 no 87 0.00164524338593616 96 2239440
SGTC_952 1185-0122 232 µM 2.91671250341931 0.00359005357788231 no 88 0.00176870832170603 69 678600
SGTC_2372 9071633 200 µM 2.90011242425338 0.00375739948877486 no 89 0.00186514420045181 52 21321366
SGTC_96 0929-0093 37.281 µM 2.89753916545533 0.00378395763094265 no 90 0.00188051387533037 54 6991579
SGTC_1160 4092-0570 10.5 µM 2.89492658470495 0.00381109366459527 no 91 0.00189623609440689 96 4994975
SGTC_3308 9128332 17.569 µM 2.89090637514318 0.00385319111424267 no 92 0.00192066269823943 151 17332805 YDL196W YDL196W
SGTC_410 α-linolenic acid 100 µM 2.84840391481573 0.00432441615744617 no 93 0.00219695595851628 77 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2996 9066192 71.4286 µM 2.84475417100979 0.00436718856946631 no 94 0.00222228550448818 101 6472854
SGTC_624 k048-0052 28 µM 2.84404748847915 0.00437551394100118 no 95 0.00222722041777654 67 6835531
SGTC_2065 5221596 34.26 µM 2.84151687477978 0.00440544334807091 no 96 0.00224497378519216 67 788581
SGTC_2850 9015429 58.44 µM 2.83766247778893 0.00445138057037712 no 97 0.00227226052670604 72 6457570
SGTC_212 3807-4682 38.772 µM 2.8373734243581 0.00445484273306804 no 98 0.00227431890612383 162 3125501 YBL034C STU1
SGTC_43 0570-0105 72.5 µM 2.82447759661142 0.00461177192758917 no 99 0.00236788794554132 208 1114046 YDL195W SEC31
SGTC_2736 butenafine 14.65 µM 2.82359758086533 0.00462265851215949 no 100 0.0023743983874873 89 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_902 1120-0002 2.07 µM 2.82249658768019 0.00463631107782732 no 101 0.00238256645499563 116 3280475
SGTC_528 3492-0019 172 µM 2.81934887714428 0.00467554209825603 no 102 0.00240605921906027 332 2869262
SGTC_1165 k072-0275 30.3 µM 2.79141952099301 0.0050368158671935 no 103 0.00262387030233743 97 6153523 YGL055W OLE1
SGTC_2366 9070441 60.58 µM 2.78771880062931 0.00508650532290679 no 104 0.00265402980514327 96 6837235
SGTC_2248 tofa 1.1 µM 2.78443964775622 0.00513089859474254 no 105 0.00268101494050911 98 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2616 abietic acid 100 µM 2.78354389222797 0.00514308517907342 no 106 0.00268842934108259 82 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_146 3448-8650 53.125 µM 2.78224925604242 0.00516074398446346 no 107 0.00269917809962529 243 2891488 YIL048W NEO1
SGTC_1803 st050068 52.4 µM 2.78121405447906 0.00517490291116991 no 108 0.00270780079479638 291 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1776 st049249 45.9 µM 2.77916770965022 0.005202993456897 no 109 0.00272491899849317 80 1822314
SGTC_2508 celastrol 40.54 µM 2.77670388212991 0.00523699482761816 no 110 0.00274565913625336 61 122724 Celastrol is a natural product and antioxidant.
SGTC_1838 st055369 84.5 µM 2.76039973341015 0.00546702042045985 no 111 0.00288653380291312 67 676036
SGTC_140 0062-0056 502.533 µM 2.74202155156363 0.00573703443196359 no 112 0.00305311675296281 91 3758964
SGTC_1028 k015-0029 4.8 µM 2.74167834162174 0.005742187552305 no 113 0.00305630838778629 97 4588309
SGTC_631 k072-0230 41.5 µM 2.74122359479363 0.00574902166886058 no 114 0.00306054187333169 83 5773147
SGTC_720 r052-1644 49.9 µM 2.74021645320655 0.00576418309738631 no 115 0.00306993670863732 85 1422863 YOR257W CDC31
SGTC_2304 7443016 91.4 µM 2.73729024680368 0.00580843548342056 no 116 0.00309738052710347 71 939854
SGTC_583 1488-1091 88.9 µM 2.71591000757196 0.00614101405071237 no 117 0.00330469405179959 86 4303273
SGTC_1239 0337-0584 35.4 µM 2.70909212816788 0.006250560640089 no 118 0.003373380129381 143 914301 YML130C ERO1
SGTC_1054 3429-0080 167 µM 2.70804397546504 0.00626755446325337 no 119 0.00338405268844939 89 1162877
SGTC_1163 k060-0048 49.9 µM 2.70717201489929 0.00628172282140049 no 120 0.00339295432676056 100 6809982
SGTC_2336 9001819 198.65 µM 2.69694947050034 0.00644995463660848 no 121 0.00349889439811423 140 2989602
SGTC_3265 9137266 49.47 µM 2.69553455161362 0.0064735511948697 no 122 0.00351378944871407 58 17224265
SGTC_218 alverine citrate 93.75 µM 2.68762530503353 0.00660686527130693 no 123 0.00359810482898208 85 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1904 st060225 78 µM 2.67556419274201 0.00681483532695032 no 124 0.00373017924064017 75 66595
SGTC_2661 dactinomycin 12.96 µM 2.66600831600888 0.00698369196668994 no 125 0.00383788971154694 100 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 2.66486494938161 0.00700414114120326 no 126 0.00385096230517119 102 688667
SGTC_2292 7671323 168.05 µM 2.65197765467196 0.00723831204524834 no 127 0.00400109187813252 128 937504
SGTC_1408 3909-7976 48.8 µM 2.63317359558492 0.00759237782795554 no 128 0.00422955497175682 111 24152374
SGTC_1098 clofazimine 15.1 µM 2.61622552583519 0.00792447361796145 no 129 0.00444539063101375 124 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_833 3852-0053 558 µM 2.59797663426586 0.00829627884079806 no 130 0.00468874373777896 93 3123681
SGTC_2507 purpurin 79.67 µM 2.58887880157911 0.00848729780319985 no 131 0.0048144488830435 130 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2358 9037157 4 µM 2.58550543083225 0.00855910016926096 no 132 0.00486181704850845 111 2388925
SGTC_2254 7938975 95.19 µM 2.58367911232595 0.00859819537948792 no 133 0.00488763476973565 150 2969277
SGTC_1027 k015-0025 8.67 µM 2.57421345734139 0.00880334261663256 no 134 0.00502341340192899 111 3598955
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 2.57092903410279 0.00887552125305252 no 135 0.0050713054234923 144 91467 include heat shock
SGTC_1492 4158-0558 28.5 µM 2.56540955097651 0.00899798608135769 no 136 0.00515270428693205 104 3967268
SGTC_492 tmb-8 126 µM 2.55132104322617 0.0093173117134848 no 137 0.00536577104196291 35 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 2.55109047216072 0.00932261919139556 no 138 0.00536932227612676 74 616764
SGTC_911 3456-4043 236 µM 2.53954835393851 0.00959170817079819 no 139 0.00554978504653237 131 914281
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 2.53584861230157 0.00967938776410228 no 140 0.00560876077881823 117 115019
SGTC_2337 9009472 200 µM 2.53336148889804 0.00973872263405978 no 141 0.00564871896434776 137 5742383
SGTC_2026 5148700 152 µM 2.52466789081864 0.0099486280298347 no 142 0.00579038366310973 110 79838
SGTC_2664 lyso-paf C-16 73.48 µM 2.5083802779926 0.010352539419013 no 143 0.00606430304263104 104 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2185 6113692 200 µM 2.50436162538553 0.0104543687732125 no 144 0.00613362899299964 87 874150
SGTC_1828 st055811 49 µM 2.50255684769257 0.0105003836824412 no 145 0.00616499111341676 69 5877589
SGTC_2907 7721985 69.9 µM 2.47903461328328 0.0111164433876754 no 146 0.00658692605995798 129 3267881
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 2.45355507662981 0.0118190013956933 no 147 0.00707259380495547 112 66535 A nucleotide analog.
SGTC_1938 st074717 56.4 µM 2.43517896293438 0.0123493146025637 no 148 0.00744221302101693 83 17250979
SGTC_61 0978-8327 98.565 µM 2.422170346939 0.0127370778994972 no 149 0.00771405825219138 132 6150059 YHR072W ERG7
SGTC_1840 st055363 71 µM 2.41589512585342 0.0129278678278186 no 150 0.00784829080084967 100 676033
SGTC_1746 st038117 42 µM 2.37118811320884 0.0143600133348317 no 151 0.00886550209306976 154 2898218
SGTC_697 0508-1955 564 µM 2.36772256633977 0.0144765258160453 no 152 0.00894897567502488 168 6243113
SGTC_2318 6029776 164 µM 2.36561694874979 0.014547713852857 no 153 0.00900002863583379 159 818325
SGTC_1337 1486-1011 40.3 µM 2.36535680479885 0.0145565298383525 no 154 0.00900635377813699 117 X1337
SGTC_1507 4075-3230 155 µM 2.35600299748084 0.0148765891348171 no 155 0.00923638431717307 89 659771
SGTC_1200 1643-0193 18.4 µM 2.35413764139978 0.0149411346498241 no 156 0.00928286753140733 137 5403974
SGTC_3058 9093861 49.47 µM 2.35052891030375 0.0150666884805894 no 157 0.0093733756449425 143 17217477
SGTC_2881 9058953 51.95 µM 2.34483606713022 0.0152665952760819 no 158 0.00951772350862858 165 17122249
SGTC_2725 haloperidol 53.21 µM 2.33836564170429 0.0154965693466732 no 159 0.00968414424620424 174 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1533 dihydroergotamine mesylate 29.4 µM 2.3290307463315 0.0158335896651013 no 160 0.00992871846773957 124 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1190 1486-1332 13 µM 2.3275382976013 0.0158880506049583 no 161 0.00996831656081851 136 4150046
SGTC_197 4544-0043 41.561 µM 2.32544819923274 0.0159645902999373 no 162 0.0100240033679273 203 896523
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 2.32285911084868 0.0160598411863607 no 163 0.0100933611744586 200 368090
SGTC_3068 9116768 49.47 µM 2.31019612337043 0.0165327511575427 no 164 0.0104386492893435 150 41904888
SGTC_2587 piperic acid 92.2 µM 2.30965068686043 0.0165533859365026 no 165 0.0104537504991711 149 5370536
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 2.30777549752761 0.0166244957430336 no 166 0.0105058132085186 94 688803
SGTC_2135 5326629 150.42 µM 2.30390903821566 0.0167719427813582 no 167 0.0106138751218437 151 5020077
SGTC_647 0140-0236 81 µM 2.29948547108849 0.016942005722084 no 168 0.0107386937285256 148 990837
SGTC_2315 7733312 200 µM 2.29570677254729 0.0170884423883799 no 169 0.0108463264787005 150 726316
SGTC_2628 lathosterol 100 µM 2.28888689671374 0.0173554732455655 no 170 0.0110429623928774 157 6710616
SGTC_1740 st038286 13.222 µM 2.24793893663753 0.019034840101309 no 171 0.0122900419600077 178 716786
SGTC_2020 4017018 200 µM 2.2403016236539 0.0193628924810062 no 172 0.0125356739589279 152 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2933 9026794 32.47 µM 2.23788744295425 0.0194675851293229 no 173 0.0126141980547354 183 17586027
SGTC_2064 5220758 200 µM 2.23449243070703 0.0196156255225704 no 174 0.0127253450179685 192 788518
SGTC_1965 Pectolinarigenin 58.4 µM 2.22432032963105 0.0200649177420282 no 175 0.0130634499316648 126 5320438 An anti-inflammatory.
SGTC_2156 5649887 115 µM 2.22427930594227 0.0200667472459759 no 176 0.0130648290664044 176 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1144 3486-0183 12.5 µM 2.22222524158373 0.0201585319513383 no 177 0.0131340437165014 185 6744069
SGTC_2316 5844804 197.44 µM 2.21458848452116 0.0205029046018747 no 178 0.0133941615708748 226 776813
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 2.19883072230174 0.021229260592461 no 179 0.0139449805514281 176 688751
SGTC_2887 9044784 58.44 µM 2.19603763752568 0.0213602528973445 no 180 0.01404462478143 207 6465546
SGTC_1430 4049-0248 69.1 µM 2.18755521533179 0.0217622647731157 no 181 0.0143510085333771 181 22774488
SGTC_1131 3454-3128 32.3 µM 2.18468754294078 0.021899611462832 no 182 0.0144558820883016 226 710982
SGTC_447 ml7 120 µM 2.184265461321 0.0219198886579418 no 183 0.0144713735870831 176 4216 Selective myosin light chain kinase inhibitor.
SGTC_207 4185-0010 4.486 µM 2.14555629190676 0.0238481080994514 no 184 0.0159541978782849 268 3761753
SGTC_867 0518-0118 155 µM 2.1444060670174 0.0239075191192052 no 185 0.0160001822821864 181 6848158
SGTC_2258 7960471 200 µM 2.13786871342946 0.0242475517154492 no 186 0.0162637000775149 127 2974708
SGTC_2726 cimetidine 79.27 µM 2.13761322507315 0.0242609226832007 no 187 0.0162740737394441 108 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_462 ag-879 158 µM 2.13364025011342 0.0244696461591698 no 188 0.016436120263702 215 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_269 exalamide 29 µM 2.1324766509834 0.0245310614097618 no 189 0.0164838409829466 135 3316 A derivative of salicylamide.
SGTC_438 sphingosine 6.67 µM 2.10982930769621 0.0257523976829316 no 190 0.0174365305383787 156 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 2.10177115986223 0.0261990603846232 no 191 0.0177866633198869 189 6312947
SGTC_638 3970-0837 4.09 µM 2.10062443274751 0.0262631468248316 no 192 0.0178369737664628 214 4118451 YLR208W SEC13
SGTC_2235 salicylic acid 500 µM 2.09463587132608 0.0265999588645076 no 193 0.0181016869514266 124 338 A COX inhibitor and kinase inhibitor.
SGTC_717 1532-0246 73.2 µM 2.08489200177542 0.0271556873417026 no 194 0.0185395524287455 210 9561992
SGTC_634 1611-4317 11.2 µM 2.08076954380123 0.027393705340845 no 195 0.0187275025615658 203 2843522
SGTC_1399 3562-5772 25 µM 2.07910477639703 0.0274903157722406 no 196 0.0188038605955141 150 23847490
SGTC_1258 0671-0043 57.1 µM 2.07610987775483 0.0276648320917936 no 197 0.0189418949046407 235 4298767
SGTC_3257 9139206 32.98 µM 2.07334208148534 0.027826934905958 no 198 0.019070227499118 120 4910041
SGTC_1667 st014849 34.6 µM 2.07088241615391 0.027971654640519 no 199 0.0191848928950603 163 5348460
SGTC_2691 st077356 60.2 µM 2.06871761385681 0.0280995435946839 no 200 0.0192862966757668 221 2839272
SGTC_3088 9117578 49.47 µM 2.06021986278778 0.0286062766415774 no 201 0.0196887634412467 166 678341
SGTC_14 0354-0009 295 µM 2.0571315412586 0.0287923107488097 no 202 0.0198367872244939 203 1713507
SGTC_139 0099-0334 718.624 µM 2.05691841649359 0.0288051859605555 no 203 0.0198470370772119 249 97690
SGTC_1488 4013-0813 75.9 µM 2.05614989210385 0.028851653518701 no 204 0.0198840352113124 145 2910057
SGTC_1484 3473-2379 286 µM 2.05091496846194 0.0291698350431585 no 205 0.0201376140958242 210 671917
SGTC_1382 3002-2117 298 µM 2.05025478776029 0.0292101673915695 no 206 0.0201697870427474 190 1497314
SGTC_2498 4'-Methoxychalcone 54.63 µM 2.02920103618596 0.0305208977601219 no 207 0.0212189090440759 206 641818 YHR062C RPP1
SGTC_1586 deoxycorticosterone acetate 53.7 µM 2.02005051213206 0.0311055758742662 no 208 0.0216890741614606 163 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_179 1273-0063 6.77 µM 1.99474401092677 0.0327709574867289 no 209 0.0230354033245527 190 3108139
SGTC_826 1683-5028 118 µM 1.97740650164466 0.0339538191306991 no 210 0.0239978498268013 200 722377
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.975698740256 0.0340722083328266 no 211 0.0240944538463633 208 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1321 1326-2144 215 µM 1.97488681341747 0.0341286134498153 no 212 0.0241404970886745 194 3513030
SGTC_1993 st073995 70.8 µM 1.97315291582653 0.0342493255583581 no 213 0.0242390715004889 196 3098394
SGTC_2634 4'-methoxyflavone 100 µM 1.96069639409155 0.0351268889694915 no 214 0.0249572249854964 226 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_3335 9143315 29.6265 µM 1.95859204855235 0.0352769464718312 no 215 0.0250802907697582 216 4899691
SGTC_675 1309-0189 238 µM 1.95646031846825 0.0354294924321595 no 216 0.0252054762899429 215 4246530
SGTC_1415 3966-0071 78.1 µM 1.9535003559705 0.0356422030191517 no 217 0.0253801675722688 185 2893185
SGTC_2446 5162541 200 µM 1.9500669073218 0.0358902496806406 no 218 0.0255840724595655 203 1549321
SGTC_2021 4019055 173 µM 1.95000463289882 0.0358947616696327 no 219 0.0255877834266422 416 44827708 YER133W GLC7
SGTC_2116 5511452 16.8835 µM 1.94797273955153 0.0360422342215404 no 220 0.0257091125425607 239 870744
SGTC_773 4358-1457 44.6 µM 1.94539302422907 0.0362301816346095 no 221 0.0258638468422865 289 1186886
SGTC_2680 butyl paraben 22.24 µM 1.9380781603086 0.0367674794088321 no 222 0.0263068437538934 172 7184 An antifungal and steroid mimetic.
SGTC_2654 protoveratrine a 100 µM 1.93775384069805 0.0367914516799636 no 223 0.0263266308843266 208 5702278 A heart drug and vasodilator.
SGTC_33 0986-0033 35.816 µM 1.93466213827151 0.0370206189383202 no 224 0.0265158846968636 189 2848082
SGTC_1849 st056239 19.2 µM 1.93366778898308 0.0370945709123713 no 225 0.0265769933249157 269 5393181
SGTC_2665 lovastatin 100 µM 1.93200331217787 0.0372186319349666 no 226 0.0266795485332785 231 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1665 st014639 11.4 µM 1.92881928797913 0.0374568962395226 no 227 0.0268766502397101 273 981133 YIL048W NEO1
SGTC_1465 k213-0056 144 µM 1.92847215490189 0.0374829477603833 no 228 0.0268982122403405 250 24048857 YMR208W ERG12
SGTC_3028 9087778 49.47 µM 1.92682171991091 0.0376070115150118 no 229 0.0270009258452431 208 17217395
SGTC_1414 3917-0015 5.4 µM 1.92214756791447 0.0379601893023065 no 230 0.0272935960487521 198 6618702
SGTC_2239 6685329 187.64 µM 1.9121525332205 0.0387244942321901 no 231 0.0279283161798251 262 805680
SGTC_998 3996-0085 177 µM 1.90731501241973 0.0390988889569034 no 232 0.0282399036629738 266 715391
SGTC_595 3909-8003 73.7 µM 1.90655526313407 0.0391579557907678 no 233 0.0282891014779733 243 699517
SGTC_307 1501-1223 22.3 µM 1.90526690165878 0.0392582856680644 no 234 0.0283726927938539 216 2830329
SGTC_581 0958-0271 211 µM 1.90263482409601 0.0394639063806033 no 235 0.0285441059125224 335 4591145
SGTC_2345 9052315 157.45 µM 1.90136237528815 0.0395636251250798 no 236 0.028627282077222 253 6469265
SGTC_1158 4092-0494 91.8 µM 1.89766722869345 0.0398543669972416 no 237 0.028869966084499 241 1148199
SGTC_2653 dihydrofissinolide 100 µM 1.89408856679657 0.0401375967498243 no 238 0.0291066275222971 179 6857746
SGTC_1304 1165-0502 251 µM 1.89081650896975 0.0403979896389295 no 239 0.0293244213095475 303 767425
SGTC_2552 juarezic acid 87.02 µM 1.88963790242683 0.040492119432717 no 240 0.0294032021869581 294 1549512
SGTC_1927 st060202 13.8 µM 1.88541236499538 0.0408310578797675 no 241 0.0296870929544326 234 688887
SGTC_3354 9151612 71.43 µM 1.88150583722838 0.0411464521730129 no 242 0.0299515709917563 252 27261949
SGTC_2997 9067075 71.4286 µM 1.86989450556772 0.0420955715745917 no 243 0.0307492344797835 302 27209819
SGTC_301 4119-0100 24.5 µM 1.86919908024035 0.0421529739837256 no 244 0.0307975610999914 323 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1935 st074532 41.6 µM 1.8627479146087 0.0426884964686126 no 245 0.0312488705903204 319 2829742
SGTC_1274 0865-0114 173 µM 1.86029234194066 0.0428937775386367 no 246 0.0314220882186637 265 870624
SGTC_298 1391-0729 10 µM 1.85934126255936 0.0429734999270421 no 247 0.0314893908827405 227 3237558
SGTC_3089 9117425 49.47 µM 1.85211208801627 0.0435833921209273 no 248 0.0320048645287267 276 9401657
SGTC_271 rotenone 740 µM 1.84903333068685 0.043845244929655 no 249 0.0322265000148915 302 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_655 k060-0012 42 µM 1.84522850736556 0.044170602378025 no 250 0.0325021526326149 263 5994525
SGTC_3066 9117245 49.47 µM 1.84402945147253 0.0442735382503922 no 251 0.032589424079914 257 17176980
SGTC_700 3453-2283 142 µM 1.83527703681593 0.0450307795685791 no 252 0.033232325853505 315 565664
SGTC_386 1509-0011 3.07 µM 1.8224885789026 0.0461559171406221 no 253 0.0341904425662414 409 3107280
SGTC_3246 9135460 32.98 µM 1.81754340525524 0.0465970052026777 no 254 0.0345669742046012 188 41446951
SGTC_1865 st057639 52.2 µM 1.81567586005682 0.0467644595329613 no 255 0.0347100545948205 272 688818
SGTC_99 0109-0120 622.8 µM 1.81540529110637 0.0467887602149063 no 256 0.0347308242834993 234 759414
SGTC_3166 9102297 49.47 µM 1.81159315760984 0.0471322183195229 no 257 0.0350245414890501 310 25237072
SGTC_272 doxorubicin 8.13 µM 1.81085654405074 0.04719881671219 no 258 0.0350815304282423 316 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1634 st006576 41 µM 1.78613622300794 0.04947789499276 no 259 0.0370386021970364 286 3915356
SGTC_1245 0418-0076 17.2 µM 1.78350409583719 0.0497256512236458 no 260 0.0372521409236269 305 6790114
SGTC_2864 9034755 47.6 µM 1.78000118801292 0.0500569060999745 no 261 0.0375378831361648 282 4930451
SGTC_2402 5553605 200 µM 1.76728485218178 0.0512742457168331 no 262 0.0385902676930823 318 6758546
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.76697431666561 0.0513042654056986 no 263 0.0386162648262687 299 3256 An antibiotic and ribosome inhibitor.
SGTC_2716 st080858 38.6235 µM 1.75894472126193 0.0520853580381568 no 264 0.0392934490929995 262 5296050
SGTC_1871 st057448 67.3 µM 1.75823603115922 0.0521547483165687 no 265 0.0393536784442167 316 691747
SGTC_2819 7996655 46.38 µM 1.75720185118429 0.0522561401579822 no 266 0.0394417049277766 263 6456960
SGTC_515 4092-1064 102 µM 1.75554930818964 0.0524184816469196 no 267 0.039582697146838 376 717353
SGTC_192 3455-0609 60.9 µM 1.75211054197856 0.0527575803565158 no 268 0.0398774009553559 286 3769639
SGTC_399 oxolinic acid 75 µM 1.74101073837045 0.0538640261281381 no 269 0.0408408481226697 262 4628 A DNA gyrase inhibitor.
SGTC_557 1315-0110 16.2 µM 1.73938107661655 0.0540280090662469 no 270 0.0409838772864991 315 6833801
SGTC_2715 st079500 56.4 µM 1.73306997056825 0.0546667885976049 no 271 0.0415416165038752 269 28246688
SGTC_2038 4100038 30.985 µM 1.7264811609653 0.0553400319601158 no 272 0.0421304428374598 339 3596803
SGTC_2174 5790901 200 µM 1.72524707124632 0.0554668560192472 no 273 0.0422414780106121 332 786020
SGTC_493 zm226600 134 µM 1.72025103175582 0.0559826318289753 no 274 0.0426934101985164 326 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1318 1280-3875 124 µM 1.71875458065961 0.0561378549210053 no 275 0.0428295344860154 358 373245
SGTC_1822 st052468 42 µM 1.71743253583017 0.0562752694691062 no 276 0.0429500855947219 277 2873678
SGTC_3120 9124077 49.47 µM 1.71739997347131 0.0562786573735675 no 277 0.0429530582606119 269 18774327 YGL155W CDC43
SGTC_1797 st048695 56.8 µM 1.71355533152672 0.0566797992013822 no 278 0.043305211574124 343 592262 YIL048W NEO1
SGTC_2581 avocatin a 64 µM 1.71124349745461 0.0569220934121673 no 279 0.0435180860078444 360 6710728 A skin care supplement.
SGTC_2216 7189485 200 µM 1.71093493314424 0.056954494422983 no 280 0.0435465624913413 242 731273
SGTC_2073 5212005 126 µM 1.70882377864072 0.057176567408131 no 281 0.0437417983487957 218 691789
SGTC_1895 st058434 18.3 µM 1.70651460686942 0.057420249697887 no 282 0.0439561545354959 319 5393175
SGTC_762 1165-0429 115 µM 1.70498539960857 0.0575820730875055 no 283 0.0440985737418599 320 5967793
SGTC_1720 st037298 9.481 µM 1.70473471706487 0.0576086349395752 no 284 0.0441219559391913 325 597396
SGTC_3062 9077494 49.47 µM 1.7038559179088 0.0577018269588874 no 285 0.0442040041198462 315 16459633
SGTC_142 0335-0849 62.6745 µM 1.70076057600685 0.0580310160386229 no 286 0.0444939775181425 477 3889043 YPR107C YTH1
SGTC_2923 7992654 58.14 µM 1.69636316214622 0.0585012158285328 no 287 0.0449085627844659 340 2985126
SGTC_2560 caryophyllene 100 µM 1.69522912520673 0.0586229582777481 no 288 0.0450159819208814 361 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1550 gossypolone 36.6 µM 1.69308830022588 0.0588533246442522 no 289 0.0452193304686496 349 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1446 4239-0190 62 µM 1.67487272005303 0.0608422794890728 no 290 0.0469796035353721 392 1340085
SGTC_1183 1254-0324 198 µM 1.67477824493187 0.0608527305319903 no 291 0.0469888744106975 321 5799357
SGTC_1038 k292-0204 154 µM 1.6742144473427 0.060915128231178 no 292 0.0470442305619493 326 4454212
SGTC_3324 9138759 60.749 µM 1.67236947606693 0.0611196681995812 no 293 0.0472257436415799 325 45595710
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.66708059174229 0.0617089879087194 no 294 0.0477491903917039 363 5106787 A p450 inhibitor.
SGTC_2523 spermine 47.74 µM 1.66589932884791 0.061841215533424 no 295 0.0478667336675524 320 1103 A DNA binding polyamine.
SGTC_2614 arthonioic acid 13.39 µM 1.66556296580729 0.0618789075981224 no 296 0.0479002462982079 314 6710684
SGTC_1521 st012942 49.4 µM 1.66152715590508 0.0623325505589967 no 297 0.0483038098034538 381 24207259
SGTC_150 3970-0969 77.2 µM 1.66102032508275 0.0623897034347697 no 298 0.048354682355691 435 6615640
SGTC_3240 9133527 49.47 µM 1.65906695639055 0.0626103577455256 no 299 0.0485511504399233 317 17617455
SGTC_1324 1418-0026 34.4 µM 1.65862719932646 0.0626601168929995 no 300 0.0485954687146671 355 1372513
SGTC_78 0336-0123 156.75 µM 1.65826529906753 0.062701089545973 no 301 0.0486319649145234 309 6765896
SGTC_1127 asiatic acid 681.4 nM 1.64739538131598 0.0639414888251807 no 302 0.0497384020451346 360 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1777 st045864 34.765 µM 1.64705439920361 0.0639807058089389 no 303 0.0497734324563142 340 4691462
SGTC_2564 betulinic acid 100 µM 1.64547708785452 0.0641623587168278 no 304 0.0499357319238303 400 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_928 2764-0428 58.7 µM 1.63712525338863 0.0651308967700179 no 305 0.0508021504805825 400 662578
SGTC_3015 9080845 49.47 µM 1.63357964476671 0.065545485526313 no 306 0.0511735723891519 357 5296973
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.62776654952096 0.0662296362821633 no 307 0.0517871979340945 251 4620898
SGTC_246 cycloheximide 667 µM 1.62749148922351 0.0662621450140174 no 308 0.0518163773549826 294 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_3113 9123498 49.47 µM 1.62370983135698 0.0667103441980095 no 309 0.0522188758966574 331 8897275
SGTC_2396 5342950 42.78 µM 1.62250944558496 0.0668531024609511 no 310 0.0523471561534291 414 1886677
SGTC_690 glyoxal 20.3 µM 1.61991717516657 0.0671621995952269 no 311 0.0526250349413575 420 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_315 k915-0449 187 µM 1.61520447218587 0.067726962036226 no 312 0.0531332112020238 431 20970215 YNL149C PGA2
SGTC_1929 genistein trimethyl ether 50.5 µM 1.61351303630152 0.0679305531109008 no 313 0.0533165466726488 353 136420
SGTC_446 go6976 132 µM 1.6109073649411 0.0682451112517691 no 314 0.0535999572627607 316 3501 A protein kinase C inhibitor.
SGTC_949 1165-0505 146 µM 1.6094516248321 0.068421337833998 no 315 0.053758812339703 409 6244267
SGTC_1800 st050079 29.0735 µM 1.60774766396518 0.0686280588771409 no 316 0.0539452274555537 557 3645560
SGTC_1016 4226-1401 38 µM 1.60468719828554 0.0690005574252995 no 317 0.0542813303113716 385 2901613
SGTC_3094 9117742 49.47 µM 1.60323226163136 0.0691781877824362 no 318 0.0544416926449604 396 17149698
SGTC_2679 rapamycin 1 nM 1.59465380537704 0.0702326860322873 no 319 0.055394836727007 512 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_790 1575-0012 79.1 µM 1.59048875392424 0.0707491086529918 no 320 0.0558623392965223 388 378741 YLR208W SEC13
SGTC_412 gemfibrozil 100 µM 1.58789074145448 0.0710727094656751 no 321 0.0561555237267569 303 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2597 laccaic acid a 100 µM 1.58309326793607 0.0716732545529414 no 322 0.0567001039024655 416 5491415 A textile dye.
SGTC_1772 st048439 82.2 µM 1.57827857859174 0.0722798608673354 no 323 0.0572508124536949 404 2927068 YDL195W SEC31
SGTC_2495 cafestol 54.53 µM 1.57736427315994 0.0723954981129723 no 324 0.0573558655581257 375 16667697 An anti-infammatory.
SGTC_190 3970-0790 3.722 µM 1.5761888234244 0.072544371907462 no 325 0.0574911467503728 343 2832352
SGTC_822 1487-0950 154 µM 1.57276629011014 0.0729791802244016 no 326 0.0578864719400748 366 1958375
SGTC_1631 benzylvanillin 81.9 µM 1.57192351532386 0.0730865541701651 no 327 0.0579841451221398 414 75506
SGTC_1454 4239-0054 42.6 µM 1.57093163547451 0.0732130797072888 no 328 0.0580992646769067 437 1340767
SGTC_3057 9095946 49.47 µM 1.56651006325428 0.0737791408511184 no 329 0.058614627272979 360 24540043
SGTC_74 000s-0487 160.283 µM 1.56393753780008 0.0741100180881479 no 330 0.0589161189637415 398 677548
SGTC_2061 5245884 80.95 µM 1.56123538865021 0.0744587868561764 no 331 0.0592341110176244 404 573863
SGTC_3014 9081533 49.47 µM 1.55978417882618 0.0746466122455715 no 332 0.0594054457340175 374 21367265
SGTC_1604 st002052 72.4 µM 1.5499118288917 0.07593396813017 no 333 0.0605813400517259 402 6254834 YHR062C RPP1
SGTC_2754 granisetron 64.02 µM 1.54959449308137 0.0759756274621657 no 334 0.0606194377776922 426 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_322 k048-0136 19.3 µM 1.54667957609179 0.0763591075034989 no 335 0.0609702652054458 375 6823282
SGTC_320 4092-0846 5.34 µM 1.54493170336615 0.0765897590807195 no 336 0.0611813919942697 385 1359356
SGTC_2468 5987765 72.9 µM 1.54434851582973 0.0766668350579921 no 337 0.06125196260377 396 26772094
SGTC_985 1493-0307 8.71 µM 1.54312118619852 0.0768292356470263 no 338 0.0614006876040877 331 3278274
SGTC_2802 7925815 54.55 µM 1.53861341688331 0.0774279497422204 no 339 0.0619493505501655 435 1262923
SGTC_1173 0443-0020 122 µM 1.53717413122786 0.0776198575894996 no 340 0.0621253366742268 415 5331295
SGTC_1311 1190-0148 100 µM 1.53537066359819 0.0778608333061157 no 341 0.0623464027767335 496 1961333
SGTC_678 1218-2179 85.9 µM 1.53320786829634 0.0781505698763175 no 342 0.0626123231034135 326 6820081 YOR116C RPO31
SGTC_2238 6671620 73.2395 µM 1.53026052004267 0.0785467239224275 no 343 0.0629761282021804 400 729941
SGTC_268 camptothecin 39.6153 µM 1.5277628255148 0.0788836298527424 no 344 0.0632857175897765 525 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3122 9126309 49.47 µM 1.5272365372784 0.0789547586028582 no 345 0.0633511019365891 361 17591206
SGTC_3231 9132313 49.47 µM 1.52692827201109 0.0789964437335809 no 346 0.0633894242302437 400 4905967
SGTC_3218 9131285 49.47 µM 1.52671084270231 0.07902585560727 no 347 0.0634164650149139 485 17156417
SGTC_1700 st030840 7.9285 µM 1.52446603909582 0.079329997369747 no 348 0.0636961670891045 431 5499307
SGTC_1768 st044301 37.178 µM 1.52245431683137 0.0796033117318512 no 349 0.0639476418712646 409 3931349
SGTC_2053 5265679 138 µM 1.52241905285274 0.0796081090730492 no 350 0.0639520569106058 429 764595
SGTC_2748 diazoxide 86.69 µM 1.52164896202864 0.0797129274296899 no 351 0.0640485311671017 332 3019 A potassium channel activatior.
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.52127816500731 0.0797634344575673 no 352 0.0640950236474846 404 6708760
SGTC_2000 st075254 36.4 µM 1.52011397367683 0.0799221686748406 no 353 0.064241166598804 358 17234175
SGTC_1754 st042065 16.137 µM 1.51823917071483 0.080178294710965 no 354 0.0644770580568131 589 1126236 YIL048W NEO1
SGTC_1397 3532-0190 20.1 µM 1.51796352528849 0.080216004241509 no 355 0.0645117969872308 327 5322280
SGTC_376 3970-0862 59.1 µM 1.51223660563615 0.0810025080654202 no 356 0.0652368408951773 428 3135186
SGTC_2234 tolnaftate 200 µM 1.50970407099245 0.0813521629097889 no 357 0.06555947602114 308 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1923 st058458 19.1 µM 1.50582008729922 0.0818906160188482 no 358 0.0660566826313712 479 3534982
SGTC_523 1934-0222 13.7 µM 1.50085638052506 0.0825826597714202 no 359 0.066696356145277 433 1361595
SGTC_575 k072-0246 11.9 µM 1.49951374994988 0.0827706046071516 no 360 0.0668702021766126 428 6796779
SGTC_1346 1488-2224 62.4 µM 1.49725609082998 0.0830873628087167 no 361 0.0671633177015067 424 3722427
SGTC_594 1487-1584 10.8 µM 1.48739539724485 0.0844815484398944 no 362 0.068455205921076 427 5013332
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.48718865774523 0.0845109656668705 no 363 0.0684824954268991 463 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2531 methyl deoxycholate 70.07 µM 1.48632253593698 0.0846342907801438 no 364 0.0685969142905162 409 16667744 Haematoxylin.
SGTC_1790 st045711 43.5 µM 1.48381416583841 0.0849922133800545 no 365 0.0689291139717071 417 585119
SGTC_1450 4112-4260 37.6 µM 1.48105261022429 0.0853875741872765 no 366 0.0692962773423451 444 1633175
SGTC_840 0245-0196 390 µM 1.47520713980685 0.0862289882744465 no 367 0.0700784312567821 481 3827528
SGTC_544 k015-0020 52.4 µM 1.47432598772308 0.0863563599069852 no 368 0.0701969206601294 412 3008304
SGTC_1496 4469-0713 57.4 µM 1.47078395367329 0.0868697850227168 no 369 0.070674776663139 427 746691
SGTC_1020 4335-0961 93.3 µM 1.47026041923747 0.0869458654702158 no 370 0.0707456182729855 410 669075
SGTC_2128 5255449 168.493 µM 1.45975550159107 0.0884829858562762 no 371 0.07217864108821 466 736008
SGTC_2750 bromebric acid 70.15 µM 1.4589577095582 0.0886005438707071 no 372 0.072288373918807 509 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2007 4011539 71.82 µM 1.45798905387853 0.0887434356989054 no 373 0.0724217800937412 474 45595301
SGTC_502 l-744,832 89.3 µM 1.4572174339484 0.08885738442776 no 374 0.0725281848201092 446 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2730 imipramine 71.33 µM 1.45703956084414 0.0888836672258 no 375 0.0725527301139264 544 3696 A tricyclic antidepressant.
SGTC_752 1896-0090 130 µM 1.4563272360525 0.0889889794134853 no 376 0.0726510899159224 439 772567
SGTC_1014 4130-3005 69.3 µM 1.45583443434788 0.0890618910011531 no 377 0.0727191970965542 477 743608
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.45520866643095 0.0891545394295375 no 378 0.0728057511882358 467 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_961 1252-1571 372 µM 1.45267162589769 0.0895308973336126 no 379 0.0731574743266613 462 6813498
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.45046892645978 0.0898586144589583 no 380 0.0734638991533585 475 165521
SGTC_250 brefeldin a 552.239 µM 1.45044278845098 0.0898625086115679 no 381 0.0734675411822002 366 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2903 5923464 63.88 µM 1.4495057388246 0.0900021971463929 no 382 0.0735981994233967 415 2876576
SGTC_1238 0333-0287 48.8 µM 1.44945767621089 0.0900093663186289 no 383 0.073604905858106 449 7226
SGTC_1769 st044406 64.4 µM 1.44867057137782 0.0901268337611704 no 384 0.0737148013151337 490 670903
SGTC_2418 pentamidine 31.67 µM 1.44851177657915 0.0901505460800531 no 385 0.0737369874173743 434 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_929 2805-0021 398 µM 1.44773365273466 0.0902668078230963 no 386 0.0738457772076648 440 3098024
SGTC_2009 4012297 12.05 µM 1.44769240224498 0.090272974285363 no 387 0.0738515478762448 444 45595307
SGTC_3117 9124945 49.47 µM 1.44532975247927 0.0906266849547172 no 388 0.0741826423065626 377 17592065
SGTC_405 ebelactone b 50 µM 1.43986406054 0.0914488907524289 no 389 0.0749529314078369 475 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.4385199329842 0.0916519327197112 no 390 0.0751432929599592 498 16486 A toxic proline analog.
SGTC_91 0417-1751 58.384 µM 1.43713657518469 0.091861249341922 no 391 0.0753395952011874 563 6795624
SGTC_335 4077-0256 27.6 µM 1.43355763073076 0.0924044240135617 no 392 0.0758492708650993 524 3121989
SGTC_79 0052-0007 94.094 µM 1.43334850309284 0.0924362365520754 no 393 0.0758791336303346 458 2801472
SGTC_2777 climbazole 1.536 µM 1.42955221323533 0.0930151384883796 no 394 0.0764227895511698 497 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1159 4092-0538 61.2 µM 1.42704441966325 0.0933990228652641 no 395 0.0767835457171162 509 717301
SGTC_1362 1611-0397 101 µM 1.42668170260655 0.0934546430770355 no 396 0.0768358310268538 466 27816
SGTC_203 k066-0004 30.888 µM 1.42650363374941 0.0934819576858514 no 397 0.0768615093829305 562 6795412
SGTC_1287 0971-0001 34.6 µM 1.42114347588452 0.0943069335586404 no 398 0.0776375265519701 521 4665869
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.42012564636866 0.094464191313261 no 399 0.0777855525537469 509 688664
SGTC_926 2268-1401 59.4 µM 1.41903055443228 0.0946336021748198 no 400 0.0779450541810726 481 2931578
SGTC_2173 5763948 167 µM 1.41702561565496 0.0949443466118439 no 401 0.0782377191825926 492 2867177
SGTC_1809 st050081 57.6 µM 1.41603895567202 0.0950975442441402 no 402 0.0783820495852244 459 5036894
SGTC_3093 9117344 49.47 µM 1.41524582923776 0.095220824066052 no 403 0.078498215846093 451 24824913
SGTC_1837 st055472 66.5 µM 1.40618538446151 0.0966374961789585 no 404 0.0798345415061065 485 676091
SGTC_2900 5328528 85.29 µM 1.40609262524054 0.0966520794458811 no 405 0.079848310994119 531 795359
SGTC_2479 5617353 43.85 µM 1.40603677397654 0.0966608609578384 no 406 0.0798566026082181 472 2731746
SGTC_1466 k213-0079 57.5 µM 1.4048303741182 0.0968506866557058 no 407 0.0800358623167957 505 3657981
SGTC_1767 st044992 70.3 µM 1.40459189746398 0.0968882430766 no 408 0.0800713336977581 489 9600693
SGTC_1891 st059073 26.2 µM 1.40310569470908 0.097122538238759 no 409 0.0802926616380534 507 688754
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.39615008848082 0.0982245958140271 no 410 0.0813346515568213 473 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_60 0986-0278 202 µM 1.39557078375932 0.0983167933547337 no 411 0.0814218927771932 356 3110598
SGTC_3236 9132701 49.47 µM 1.39510262881609 0.0983913474731097 no 412 0.0814924467881874 476 24282524
SGTC_2624 nerol 100 µM 1.39487319986365 0.0984278993635072 no 413 0.0815270400609541 446 637566 A natural product oil.
SGTC_329 k048-0121 21.3 µM 1.393320217893 0.0986755769730943 no 414 0.0817614897357557 459 6832902
SGTC_746 1095-0025 46.6 µM 1.38682470547127 0.0997164595523178 no 415 0.0827476108709195 518 6749286
SGTC_758 0868-0029 16 µM 1.384517364328 0.100088126850144 no 416 0.083100047447958 481 762687
SGTC_2034 5197015 53.07 µM 1.38424294834106 0.100132397081406 no 417 0.0831420383264795 510 780676
SGTC_259 usnic acid 108.925 µM 1.38177761633527 0.100530758675907 no 418 0.0835199969555644 503 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2974 9094440 9.66 µM 1.38148555329809 0.100578028284576 no 419 0.0835648583768666 535 25236134
SGTC_2241 6772625 37.8075 µM 1.37642106954992 0.101400281002648 no 420 0.084345654288419 474 2285411
SGTC_124 0136-0217 7.121 µM 1.37195793093012 0.10212895109379 no 421 0.0850382672434994 590 3976905
SGTC_1944 st076371 56.9 µM 1.36919688442303 0.102581633831462 no 422 0.0854688698278699 480 24208455
SGTC_3096 9117468 49.47 µM 1.36229346962501 0.103719850415507 no 423 0.0865526438646247 381 41316311
SGTC_1659 st012954 42.1 µM 1.36080899450722 0.103965799115523 no 424 0.0867870293654266 482 24207262
SGTC_3099 9120367 49.47 µM 1.35489090818648 0.104950514979699 no 425 0.0877261583860338 490 24824940
SGTC_484 loperamide 105 µM 1.35470439646479 0.104981658212297 no 426 0.0877558782967777 388 3955 An opioid-receptor agonist.
SGTC_387 norethindrone acetate 66.7 µM 1.3532225940929 0.105229323371397 no 427 0.0879922646164411 465 541197
SGTC_2828 7998861 71.43 µM 1.34760988473899 0.106171252235571 no 428 0.088891944819969 418 2988188
SGTC_610 4215-0184 155 µM 1.34665717331016 0.106331739722336 no 429 0.08904533566089 544 5605015
SGTC_3165 9101544 49.47 µM 1.34582474095917 0.106472109137824 no 430 0.0891795222236949 525 5002184
SGTC_2122 5258151 111.688 µM 1.34395172912036 0.106788435973788 no 431 0.0894819983720159 511 2173356
SGTC_77 0828-0286 12.516 µM 1.34204368926394 0.107111375298473 no 432 0.0897909151476658 533 745345
SGTC_2188 6126565 140.678 µM 1.34152415855751 0.107199428714029 no 433 0.0898751657183594 451 874518
SGTC_3319 9138450 16.7555 µM 1.33935748013407 0.107567214094381 no 434 0.0902271622847457 487 2029690
SGTC_1690 st023502 41.2 µM 1.33711202133708 0.107949330693222 no 435 0.0905930368848843 494 24207482
SGTC_196 k015-0023 18.111 µM 1.33666424353279 0.108025647168714 no 436 0.0906661292320155 558 5211998
SGTC_1019 4262-0212 3.4 µM 1.33588700950504 0.108158206343484 no 437 0.0907931037868292 611 4677213
SGTC_946 3434-1334 87.4 µM 1.33525133645176 0.108266708960474 no 438 0.0908970499741977 511 4047976
SGTC_2537 larixol 68.93 µM 1.33449067631028 0.108396648472983 no 439 0.0910215502395544 570 6708759
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.3341993004536 0.108446452368654 no 440 0.0910692743739937 567 5379071
SGTC_233 rapamycin 362 pM 1.33189853793318 0.108840292311225 no 441 0.0914467657809067 513 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2805 7950783 58.44 µM 1.32985218224948 0.109191446567892 no 442 0.0917834894982163 595 1178958 YDL195W SEC31
SGTC_1564 D-Arginine 115 µM 1.32862270864102 0.109402815091588 no 443 0.0919862381043301 518 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2524 avocatin b 10.57 µM 1.32616660547249 0.109825942816423 no 444 0.0923922590163204 477 6710748
SGTC_3048 9093155 49.47 µM 1.32463232169459 0.110090858469635 no 445 0.0926465651085284 449 25236002
SGTC_1237 0330-0133 46.1 µM 1.32433966883363 0.110141441114887 no 446 0.0926951307844861 485 X1237 YHR072W ERG7
SGTC_2810 7959871 45.46 µM 1.32222968530915 0.110506627905619 no 447 0.093045839446472 591 2974535
SGTC_2107 5363541 170.161 µM 1.32211026969848 0.110527321763094 no 448 0.0930657172692611 525 244052
SGTC_2964 9083345 53.42 µM 1.31800043645447 0.111241219736572 no 449 0.0937517509029498 494 17741579
SGTC_1723 st034307 2.5525 µM 1.31409238379147 0.111923123875744 no 450 0.0944075584316799 520 867466
SGTC_1473 k844-0725 134 µM 1.31356307775174 0.112015710204852 no 451 0.0944966403709191 603 54682906
SGTC_1539 benzyladenosine 56 µM 1.30988806983935 0.11266005356825 no 452 0.0951168518074203 509 92208 A nucleotide analog.
SGTC_90 0870-0863 4.608 µM 1.30899984748735 0.11281618301202 no 453 0.0952672011982719 576 1738164
SGTC_59 0330-0160 1.33 µM 1.30837789558808 0.112925600034867 no 454 0.0953725831045748 693 4293482
SGTC_1308 1187-1617 41.4 µM 1.30534158192474 0.113460851749497 no 455 0.0958882804214558 578 2882570
SGTC_2385 9074692 200 µM 1.30384929160136 0.113724579860509 no 456 0.0961424862414091 554 17046906
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.30248298874394 0.113966425484508 no 457 0.0963756647411006 518 229346 A bile salt which induces apoptosis.
SGTC_2902 5787006 60.46 µM 1.30144456589463 0.114150478867706 no 458 0.0965531637471803 517 591003
SGTC_706 4262-0057 46.9 µM 1.30083020934909 0.11425946901197 no 459 0.0966582895420695 540 883298
SGTC_1474 0330-0125 5.35 µM 1.29832283091143 0.114705059749832 no 460 0.0970882121111564 542 X1474
SGTC_300 r073-0011 5.04 µM 1.29809085302147 0.114746347362302 no 461 0.0971280585497634 614 2735780
SGTC_853 0419-0306 21 µM 1.2939945718327 0.115477149229068 no 462 0.0978336478918118 523 762713
SGTC_2483 5729050 27.16 µM 1.2939096814608 0.115492329095603 no 463 0.0978483099941949 655 2865180
SGTC_2617 dihydrotanshinone i 20.83 µM 1.29193380929214 0.115846049846176 no 464 0.0981900340101724 591 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_627 1391-0720 175 µM 1.29048067229874 0.116106680980795 no 465 0.0984419091274756 539 997839
SGTC_452 diindolylmethane 8 µM 1.28856558230204 0.116450802188066 no 466 0.0987745776333636 486 3071 Inhibits expression of several cancer promoting factors.
SGTC_3119 9125183 49.47 µM 1.28528764992345 0.117041489339443 no 467 0.099345892125964 421 22695334
SGTC_652 0437-0092 114 µM 1.2833595658414 0.117389922361974 no 468 0.0996830664530825 519 3091274
SGTC_89 0302-0250 142.109 µM 1.28297933230933 0.117458722752733 no 469 0.0997496585013616 612 4203518 YLR208W SEC13
SGTC_479 n-linoleoylglycine 10 µM 1.28106671839145 0.117805228824398 no 470 0.100085116304336 509 6433346 An anti-infammatory.
SGTC_191 3914-0123 66.505 µM 1.27577846784918 0.11876705808884 no 471 0.101016920593518 418 3144412
SGTC_342 k048-0088 23.3 µM 1.27452292310041 0.118996229704798 no 472 0.101239077002771 554 6820570
SGTC_2205 7238770 200 µM 1.27411271186772 0.119071172222556 no 473 0.101311736982653 520 279867
SGTC_1502 4534-4282 27.7 µM 1.2692470459078 0.119962635363078 no 474 0.102176483215644 527 3278949
SGTC_3278 9139605 49.47 µM 1.26698734177266 0.120378243006646 no 475 0.102579908038433 560 7958859
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.26282690965255 0.121146085326355 no 476 0.103325695834502 545 5355888
SGTC_712 r015-0009 80.6 µM 1.26203322922575 0.121292956073302 no 477 0.103468414816701 509 6813872 YLR060W FRS1
SGTC_2263 7948595 193.29 µM 1.26164929246063 0.121364048578411 no 478 0.103537505345174 493 2971371
SGTC_2973 9094665 17.96 µM 1.26145882797874 0.121399327228119 no 479 0.10357179240007 628 25237061 YIL048W NEO1
SGTC_123 0083-0120 66.675 µM 1.25981208778408 0.121704644189363 no 480 0.103868579078913 601 16001701
SGTC_2072 5231554 129 µM 1.2559341271595 0.122425775113429 no 481 0.104569927036184 570 789545
SGTC_2774 tamoxifen 10.92 µM 1.2496950415506 0.123592255239997 no 482 0.105705484665644 556 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1755 st041960 45.185 µM 1.24905332147987 0.123712673325524 no 483 0.105822785953575 567 2257073
SGTC_795 0685-0265 78 µM 1.24854296271833 0.123808500227661 no 484 0.105916142594304 589 302754
SGTC_1195 1502-0147 41.1 µM 1.24826207737279 0.123861262491361 no 485 0.105967548527914 610 817940
SGTC_882 0843-0131 351 µM 1.24816570734957 0.123879368523171 no 486 0.105985189738884 619 5425421
SGTC_41 0478-0632 82.643 µM 1.24455610374622 0.124558876597551 no 487 0.106647482207541 666 3750424
SGTC_526 4469-0568 170 µM 1.2415454593834 0.125127620157848 no 488 0.107202157818868 581 2901964
SGTC_1876 myriocin 605 nM 1.2359383161233 0.126191699339223 no 489 0.108240746549431 585 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2154 5570129 200 µM 1.23566885632649 0.12624299363909 no 490 0.108290839255937 629 673366
SGTC_3049 9092223 49.47 µM 1.23515202533647 0.126341418118853 no 491 0.108386965071278 562 8623917
SGTC_820 1582-0060 59.9 µM 1.23465175732164 0.126436739288335 no 492 0.108480068789008 608 3848840
SGTC_979 1426-2828 121 µM 1.23424391209659 0.126514487266991 no 493 0.108556014480117 631 747872
SGTC_1980 st071811 45.7 µM 1.23041603250081 0.127245823416493 no 494 0.109270676335752 580 4974850
SGTC_1317 1273-0028 910 nM 1.22583638140534 0.128124647037338 no 495 0.110130126649697 584 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1948 st076329 66.6 µM 1.21618072970765 0.129991333152108 no 496 0.111958041405225 556 24208413
SGTC_2855 9016525 58.44 µM 1.21568098183025 0.130088457051305 no 497 0.112053235820292 616 43811474
SGTC_2403 6032726 181.2 µM 1.21313189263102 0.130584643177933 no 498 0.112539699136605 599 2881040
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.20916683174046 0.131359049580438 no 499 0.113299378819711 644 5393153
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.20818745200566 0.13155081721198 no 500 0.113487583616807 574 2374 Ca(2+)-ATPase inhibitor.
SGTC_3051 9093778 49.47 µM 1.20796383932317 0.13159462881782 no 501 0.113530585914294 530 17217378
SGTC_1106 tegaserod maleate 11.7 µM 1.20442890733864 0.132288553032567 no 502 0.114211922336139 649 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_3176 9106582 49.47 µM 1.20399159883638 0.132374573797111 no 503 0.114296412844792 439 17018027
SGTC_1210 3013-0140 750 nM 1.20040153153652 0.133082215236847 no 504 0.114991717180646 653 905973
SGTC_167 3672-0051 66.205 µM 1.19973191162496 0.133214492209982 no 505 0.115121737619769 579 3237971
SGTC_3170 9103054 49.47 µM 1.19566076147594 0.134020655720105 no 506 0.115914484786915 574 16432970
SGTC_1178 0988-0033 191 µM 1.19464528045042 0.134222261121318 no 507 0.116112825001058 646 5392207
SGTC_1411 3909-8223 150 µM 1.19438071281095 0.134274820430452 no 508 0.116164538960978 644 X1411
SGTC_1624 st003710 6.25 µM 1.19097427895569 0.134952809182177 no 509 0.116831841216034 678 24207033
SGTC_938 3126-1755 342 µM 1.19074198015398 0.134999129410177 no 510 0.116877446081369 664 1777771
SGTC_3194 9111903 49.47 µM 1.18995271307029 0.135156590204176 no 511 0.117032489135587 613 17087251
SGTC_31 0508-1974 57.237 µM 1.18426373707375 0.136295280227391 no 512 0.118154339368692 624 6810525
SGTC_2412 st077135 33.4 µM 1.18243139178529 0.136663431054489 no 513 0.118517286724122 640 13258915
SGTC_400 oxethazaine 37.5 µM 1.18220710520045 0.136708540890239 no 514 0.118561767037518 608 4621 A local anesthetic.
SGTC_355 1311-2252 105 µM 1.18137147762735 0.136876696830171 no 515 0.118727591792988 642 5338538
SGTC_294 k038-0071 157 µM 1.18085669077466 0.136980359334955 no 516 0.118829829357385 655 24152826
SGTC_213 1246-0773 967 nM 1.18031206995981 0.137090087885944 no 517 0.118938059675552 661 6251622
SGTC_1499 4480-0877 67.3 µM 1.17992786918267 0.137167531609539 no 518 0.119014452224991 586 2861909
SGTC_910 3454-3003 490 µM 1.17606108175783 0.137948627718535 no 519 0.119785234187061 658 820824
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.17508303978228 0.138146673290314 no 520 0.119980747648962 685 688801
SGTC_2690 usnic acid 100 µM 1.17430061693909 0.138305247093433 no 521 0.120137318142308 714 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1481 3346-2004 36 µM 1.17409736074315 0.138346461364743 no 522 0.120178015251677 647 2770522
SGTC_1370 2001-0092 44.6 µM 1.17156880177309 0.138859877287432 no 523 0.120685109911025 750 790957
SGTC_3217 9129673 49.47 µM 1.16883647939863 0.139416123528868 no 524 0.121234759896083 621 17248312
SGTC_1605 st000082 49.1 µM 1.16580046825343 0.140035970324125 no 525 0.121847563932915 644 1114022
SGTC_2830 7992007 71.43 µM 1.16419260272763 0.140364997275967 no 526 0.122172983673789 610 1952075
SGTC_265 mycophenolic acid 32.932 µM 1.16398054003891 0.140408432060231 no 527 0.122215949051725 701 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1684 st024538 14.6195 µM 1.16365710220779 0.140474696328589 no 528 0.122281500235147 658 6732859
SGTC_2150 5556613 200 µM 1.15938843245561 0.141351228521246 no 529 0.123148944868528 686 743190
SGTC_2077 5212015 200 µM 1.15921632712973 0.141386646347824 no 530 0.123184008943893 613 780900
SGTC_2187 6125751 200 µM 1.15795356601985 0.141646695906256 no 531 0.123441493028233 665 874498
SGTC_2782 7736369 71.43 µM 1.15315794879623 0.142637242695464 no 532 0.124422779988829 694 2950836 YOL077C BRX1
SGTC_1010 4112-3296 15.2 µM 1.15186940363169 0.1429041913425 no 533 0.124687371371584 689 704384
SGTC_379 3970-0972 5.9 µM 1.14619855759313 0.144083034843591 no 534 0.125856502293956 650 2898042 YBL034C STU1
SGTC_830 4076-0286 57.8 µM 1.14572007306599 0.144182800326116 no 535 0.125955497751706 807 6866659
SGTC_1623 st003709 20.3 µM 1.14073427969404 0.145225124265687 no 536 0.126990258396525 734 16192618
SGTC_1596 piperlongumine 63 µM 1.1388869216163 0.145612614892796 no 537 0.127375160581874 736 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2375 9072683 200 µM 1.13746139732828 0.145912098989308 no 538 0.127672726635585 750 16798029
SGTC_178 4092-0806 87.505 µM 1.13346445344192 0.146754010856663 no 539 0.12850963028659 742 2169044
SGTC_149 3970-0822 46.1 µM 1.1322396889656 0.147012644978001 no 540 0.128766839140799 811 3114250 YBL034C STU1
SGTC_2153 5569715 200 µM 1.13016595572997 0.147451252770845 no 541 0.129203151043885 660 2054701
SGTC_3038 9091290 49.47 µM 1.12956994441553 0.147577475006876 no 542 0.129328740754576 670 25236843
SGTC_174 3553-0389 74.3 µM 1.12894627264158 0.147709632600765 no 543 0.129460249553337 614 738071
SGTC_2291 7917025 104.35 µM 1.12834771800768 0.147836542323183 no 544 0.129586549203113 687 2964612
SGTC_1915 st067105 30.6 µM 1.12589861327648 0.148356578879196 no 545 0.13010421820216 683 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_832 4083-0019 164 µM 1.12510603530336 0.148525134576748 no 546 0.130272052072394 878 1990758
SGTC_52 0329-0193 875 nM 1.12275326691996 0.14902624631148 no 547 0.130771149112736 679 3739292
SGTC_1899 st063254 59.6 µM 1.12077577824869 0.149448300510216 no 548 0.131191658438783 611 3093813
SGTC_2112 5488546 200 µM 1.12009788659274 0.149593165963379 no 549 0.131336025573213 694 600757
SGTC_2758 dehydroepiandrosterone 69.35 µM 1.1187578824729 0.149879800455986 no 550 0.131621722073298 706 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2768 sulfasalazine 50.2 µM 1.11875663410791 0.149880067659012 no 551 0.131621988431633 685 5384001 An antioxidant and salicylic acid derivative.
SGTC_3134 9127454 49.47 µM 1.11232153517871 0.151261674041351 no 552 0.132999963911451 699 24262820
SGTC_20 0481-0013 4.944 µM 1.11015457869153 0.151728817064107 no 553 0.133466210859287 682 182045
SGTC_1670 st016595 4.04 µM 1.11013780890182 0.151732435956744 no 554 0.13346982346103 699 597879
SGTC_2940 9060638 45.86 µM 1.10956428388924 0.151856236224198 no 555 0.133593414537664 689 4027022
SGTC_745 0469-0705 296 µM 1.10865866659056 0.1520518580607 no 556 0.133788729637611 786 3486736
SGTC_2927 9011802 47.9 µM 1.10511559444824 0.152818802556536 no 557 0.134554752098272 676 43912568
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.10473530478748 0.152901273438458 no 558 0.13463715037894 631 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_904 1141-0088 396 µM 1.10453662173272 0.152944372241583 no 559 0.134680213287093 679 1378119
SGTC_2859 9028643 45.46 µM 1.10378670354615 0.1531071188555 no 560 0.134842837012521 666 17151580
SGTC_2040 5100729 123 µM 1.10362704387506 0.153141782877671 no 561 0.134877477443651 714 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.10298601414649 0.153281010451733 no 562 0.135016619396609 754 676296 Flavone; oxidizing agent.
SGTC_1254 0550-0035 264 µM 1.10206508242571 0.153481177704485 no 563 0.13521668915139 752 15121435
SGTC_787 4152-0075 138 µM 1.10111524781622 0.153687808369933 no 564 0.135423250798907 678 9566539
SGTC_2059 5238311 157 µM 1.09834474940211 0.154291564839395 no 565 0.136026989212915 665 703021
SGTC_1510 1123-0200 71.5 µM 1.09828883525542 0.154303765965832 no 566 0.136039192788605 792 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_3261 9137475 49.47 µM 1.09690828469879 0.154605220734285 no 567 0.13634074339062 473 17027690
SGTC_2954 9074818 52.69 µM 1.09555499948081 0.154901099400202 no 568 0.13663678203043 685 16648742
SGTC_2129 girgensonine 121.053 µM 1.09542349037607 0.154929872124912 no 569 0.136665573789733 762 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1610 st001799 48.1 µM 1.09432934650099 0.155169395442829 no 570 0.136905279455503 643 621897
SGTC_1804 st050076 49.1 µM 1.09336668605428 0.155380337262742 no 571 0.137116417146196 718 3895976
SGTC_3034 9090421 49.47 µM 1.09336372105105 0.155380987257707 no 572 0.137117067795722 675 17173761
SGTC_1901 st060216 58.6 µM 1.09167869518759 0.155750672845867 no 573 0.137487176362567 712 688792
SGTC_326 k292-0812 17.5 µM 1.08839807495644 0.156472085750697 no 574 0.138209705313071 697 3579357
SGTC_2217 6934799 96.0675 µM 1.08222680632006 0.157835109486528 no 575 0.139575879996716 711 675606
SGTC_3294 9122953 26.2835 µM 1.08118557907272 0.158065847737316 no 576 0.139807285748931 726 16459826
SGTC_312 4092-0653 6.84 µM 1.08000510245458 0.158327711646257 no 577 0.140069954012536 823 1148278
SGTC_3281 9140613 49.47 µM 1.07638991261372 0.159131435062995 no 578 0.140876455926423 665 16013766
SGTC_1640 st009078 66.4 µM 1.07606610083588 0.159203554584826 no 579 0.140948847544527 658 690618
SGTC_973 1325-0077 65.9 µM 1.07564132605174 0.159298193093853 no 580 0.141043848787023 784 2835149
SGTC_591 4299-0174 154 µM 1.07539454072718 0.159353193017264 no 581 0.141099062474386 722 5509088
SGTC_1932 st074806 40.9 µM 1.07187229220332 0.160139535523268 no 582 0.141888698442253 773 17251235
SGTC_2224 6650123 117.647 µM 1.07108083436922 0.160316577066825 no 583 0.142066542495748 693 2908370
SGTC_3272 9137413 49.47 µM 1.06981731133709 0.160599480087747 no 584 0.142350774273227 703 17614870
SGTC_994 3910-0338 138 µM 1.06966822115132 0.160632882900694 no 585 0.142384337736424 759 3479481
SGTC_609 0986-0026 86.3 µM 1.06768830900997 0.161076901229818 no 586 0.142830566892317 752 2848610
SGTC_724 3910-0327 137 µM 1.06734735156042 0.161153445665621 no 587 0.142907506592197 747 2885483
SGTC_970 1315-0089 19.5 µM 1.06626345123823 0.161396937279394 no 588 0.143152283157331 701 6811083 YLR033W RSC58
SGTC_3187 9109394 49.47 µM 1.06533275551979 0.16160620376311 no 589 0.143362687488054 742 17098090
SGTC_1955 wogonin 32.4 µM 1.06481365001051 0.161723001192477 no 590 0.143480133430167 726 5281703 A flavanone.
SGTC_730 1436-0052 41.2 µM 1.06442547580568 0.161810375349945 no 591 0.143567999021984 705 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_378 3970-0959 8.33 µM 1.06377666113884 0.161956485747775 no 592 0.143714943238579 742 6615653
SGTC_2199 6590217 200 µM 1.06203784019422 0.162348484755524 no 593 0.14410925352008 667 703109
SGTC_303 1348-1668 34.2 µM 1.05993241951777 0.162823955765648 no 594 0.144587672721973 725 5380509
SGTC_3220 9131269 49.47 µM 1.05964123554886 0.162889785584396 no 595 0.144653923199334 736 17722206
SGTC_2201 6605497 169.863 µM 1.05827285741278 0.163199375281093 no 596 0.144965531807208 745 670741
SGTC_2364 9055074 200 µM 1.05490849367851 0.163962172777459 no 597 0.145733588642452 707 6470630
SGTC_2422 chlorphenesin carbamate 384.24 µM 1.05308803160991 0.16437588656902 no 598 0.146150323816145 778 2724 A muscle relaxant with antifungal properties.
SGTC_2520 obtusaquinone 4.71 µM 1.05095002047398 0.1648626291453 no 599 0.146640772557988 754 5967872
SGTC_3228 9131799 49.47 µM 1.05078999414375 0.164899098473545 no 600 0.1466775261494 719 17015818
SGTC_3035 9091303 49.47 µM 1.0495618334507 0.165179165036682 no 601 0.146959806211459 758 25237002
SGTC_2210 7115885 190.385 µM 1.04432534652951 0.166376732392561 no 602 0.148167444922934 789 2927039
SGTC_1681 tripelennamine 100 µM 1.04354797019697 0.166554992544931 no 603 0.148347287908769 686 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2717 st081029 62.2815 µM 1.04307771054407 0.166662887600124 no 604 0.148456151497756 737 5292846
SGTC_1091 telmisartan 47.6 µM 1.04018670925758 0.167327181554173 no 605 0.149126582540602 778 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1662 st014054 52 µM 1.03794291504534 0.167843934856052 no 606 0.14964831618519 733 2838777
SGTC_2439 5492030 7.2 µM 1.03681195652753 0.168104787408549 no 607 0.149911751089953 740 5722370
SGTC_3145 9085516 49.47 µM 1.0346291540918 0.168608982118846 no 608 0.150421066656526 730 25236195
SGTC_963 1269-2853 151 µM 1.03347095871943 0.168876902241768 no 609 0.150691777179847 712 3668223
SGTC_1316 1272-0050 65.9 µM 1.03240977621683 0.169122620786132 no 610 0.150940097047089 756 7340392
SGTC_1101 ebselen 5.29 µM 1.03177179073362 0.169270457815388 no 611 0.151089518567025 827 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_136 0097-0015 404.482 µM 1.02618406376566 0.170568816071264 no 612 0.152402415816137 837 4861337
SGTC_567 1080-0542 68.4 µM 1.0254988353082 0.170728472788114 no 613 0.152563937342706 721 5950415
SGTC_3250 9135583 49.47 µM 1.02549168884688 0.170730138401647 no 614 0.152565622499336 746 7699353
SGTC_2018 5133068 143 µM 1.02494668403716 0.170857192382222 no 615 0.152694172623179 741 785362
SGTC_2324 6149169 200 µM 1.02385049935306 0.17111292307377 no 616 0.152952946907504 740 2888231
SGTC_648 0375-0473 33.3 µM 1.02339691691034 0.171218811619289 no 617 0.153060108270559 804 1713139
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.01959561593958 0.172107869408329 no 618 0.153960142530902 785 97141
SGTC_2662 daunorubicin 22.37 µM 1.01814737483659 0.172447361399362 no 619 0.154303962087419 742 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1907 st060210 83.7 µM 1.01726539512149 0.172654321348803 no 620 0.154513596973941 854 688793
SGTC_2400 5203494 178.7 µM 1.01638460148101 0.172861160946362 no 621 0.154723137737212 712 6777674
SGTC_1375 2910-0797 186 µM 1.01577339309242 0.173004785745012 no 622 0.154868654482153 766 742508
SGTC_1893 st059353 36.1 µM 1.01450737801282 0.173302522038334 no 623 0.155170355337571 768 3112488
SGTC_2267 7931562 200 µM 1.01426779786981 0.17335890221396 no 624 0.155227492707363 705 934880
SGTC_1783 st039459 87.517 µM 1.01419206523914 0.173376726733284 no 625 0.155245557039787 826 729761
SGTC_1617 st002906 78 µM 1.01376541843631 0.173477164616141 no 626 0.155347350059573 812 5150859
SGTC_2183 6420625 130.508 µM 1.01376131624603 0.173478130501686 no 627 0.155348329008732 838 2897619
SGTC_2204 7233102 200 µM 1.01149598616079 0.174012038988585 no 628 0.155889550626647 748 2172480
SGTC_977 1348-1378 135 µM 1.01143824689057 0.174025661013626 no 629 0.155903361637169 814 X977
SGTC_311 1315-0136 58 µM 1.01075746714872 0.174186323767355 no 630 0.156066262343147 792 6759207
SGTC_2803 7707263 71.43 µM 1.00520547462031 0.175500101055932 no 631 0.157398959787575 754 2199229
SGTC_3053 9095903 49.47 µM 1.00423892614977 0.175729457265416 no 632 0.157631731818173 822 17174018
SGTC_3203 9113543 49.47 µM 1.00381804505962 0.175829389167719 no 633 0.157733162458107 748 17018012
SGTC_18 0111-0177 500 nM 1.00368355336918 0.175861329789689 no 634 0.157765583448006 883 721752
SGTC_2383 9036125 200 µM 1.00244507374734 0.176155630779405 no 635 0.158064340961741 769 79580
SGTC_287 k060-0039 29.6 µM 1.00065005367486 0.176582735956346 no 636 0.158498011097529 803 5861974
SGTC_3124 9127567 49.47 µM 0.99691160797856 0.177474357984547 no 637 0.15940370836303 777 17592030
SGTC_467 ro 31-8220 72.8 µM 0.995347083416699 0.177848340275991 no 638 0.159783742807445 820 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_782 0083-0095 30.5 µM 0.994447848560631 0.178063517210616 no 639 0.160002441560128 846 3591729 An indicator and reagent.
SGTC_572 0960-0087 17.7 µM 0.994023191368569 0.178165190003958 no 640 0.160105788488873 875 6796365
SGTC_1401 3807-4679 7.6 µM 0.992355739454757 0.178564770560956 no 641 0.160512010870726 782 3291456
SGTC_476 mead acid 10 µM 0.991319942303987 0.178813268225374 no 642 0.160764689115104 752 5312531 An omega 9 fatty acid.
SGTC_2892 9047358 58.44 µM 0.986636260224883 0.179939644190335 no 643 0.161910493802584 743 6466771
SGTC_2623 humulene 100 µM 0.985024498174259 0.180328284166237 no 644 0.162306018802598 695 6187145 An anti-inflammatory.
SGTC_1479 0549-0158 134 µM 0.985008716254669 0.180332092221397 no 645 0.162309894778836 862 5440202
SGTC_1520 flindersine 88 µM 0.983556219395792 0.180682784494377 no 646 0.162666880149348 840 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1073 triclabendazole 3.09 µM 0.981854005476179 0.181094312517139 no 647 0.163085888890685 870 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1724 st037281 8.293 µM 0.98052501246471 0.181416018337085 no 648 0.163413514603717 792 574124 YDL195W SEC31
SGTC_370 0180-0345 38.7 µM 0.980122279681189 0.181513577391714 no 649 0.163512881350158 746 3989527
SGTC_3180 9109287 49.47 µM 0.978527572370067 0.18190020587824 no 650 0.16390673063151 771 18891271
SGTC_2993 9054257 71.4286 µM 0.9761176305116 0.182485460204878 no 651 0.1645030877164 826 6470217 YGL055W OLE1
SGTC_899 1083-0020 478 µM 0.974569049089691 0.182862153194537 no 652 0.164887036330376 848 767123
SGTC_2050 5263056 171 µM 0.974276014271567 0.182933488589128 no 653 0.164959755371697 889 763468 YGL055W OLE1
SGTC_114 0364-0001 490.298 µM 0.973875724903014 0.183030961724467 no 654 0.165059124081515 814 4003655
SGTC_2144 5628481 200 µM 0.971704980261774 0.183560116715795 no 655 0.165598669227057 808 2818399
SGTC_599 1935-0052 86.5 µM 0.968002951602466 0.184464744439718 no 656 0.166521447803254 854 9557311
SGTC_2274 7947094 46.08 µM 0.966336832944818 0.184872780512838 no 657 0.166937830467048 888 2971028
SGTC_2331 7980721 200 µM 0.96581031934188 0.185001841387573 no 658 0.167069551929021 848 2981221
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.965383685666913 0.185106460388426 no 659 0.167176334895255 817 279621
SGTC_1961 st076550 68.7 µM 0.960920007056877 0.186203245119597 no 660 0.168296195137368 785 1579337
SGTC_3254 9136651 49.47 µM 0.959453741350643 0.186564402910116 no 661 0.168665106407529 882 16454030
SGTC_3300 9124615 50.48 µM 0.959029095235091 0.186669078991471 no 662 0.168772044016395 839 24824903
SGTC_547 1120-0019 610 nM 0.958575197156568 0.18678100593283 no 663 0.168886396239844 829 3676939
SGTC_1759 st043059 70 µM 0.957505095667597 0.187045047125408 no 664 0.169156187830443 857 669426
SGTC_349 k015-0014 24 µM 0.956728106171379 0.187236909290829 no 665 0.16935225400013 791 2196908
SGTC_705 1124-0212 310 µM 0.956172126147358 0.18737427221071 no 666 0.169492639950632 858 9554485
SGTC_371 0195-0006 7.36 µM 0.955134533380016 0.187630791094632 no 667 0.169754833634479 750 3928593
SGTC_2137 5261020 140 µM 0.953925453492584 0.187929979456395 no 668 0.1700606890931 833 763655
SGTC_1354 1498-1681 81 µM 0.953398975469219 0.188060349119666 no 669 0.170193980164779 902 5754243
SGTC_3007 9078383 71.4286 µM 0.951530878776181 0.188523388786048 no 670 0.170667475525587 851 6496995
SGTC_3197 9113331 49.47 µM 0.948618617145276 0.189246643398752 no 671 0.171407309402318 851 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2897 9048598 12.99 µM 0.947591107871113 0.18950223051835 no 672 0.171668827377391 814 6467404
SGTC_37 0566-0070 1.56 µM 0.946987360821437 0.189652508202327 no 673 0.171822609734421 905 1626686
SGTC_3159 9100096 49.47 µM 0.946215259720095 0.189844797401206 no 674 0.172019402248494 832 25236875
SGTC_1672 st016598 6.51 µM 0.944314393626286 0.190318712369338 no 675 0.172504506371561 825 4665860 YNL267W PIK1
SGTC_1206 3978-0017 132 µM 0.942831737691942 0.190688865137945 no 676 0.172883487609728 808 3873677
SGTC_626 0214-0009 33 µM 0.942302153741798 0.190821185551541 no 677 0.173018982907978 898 3437874
SGTC_2607 solasodine 47.35 µM 0.941418755279661 0.191042034433905 no 678 0.173245152983669 854 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_40 0327-0103 19.753 µM 0.94120990726254 0.191094269166166 no 679 0.173298650323404 825 409036
SGTC_2878 9043973 25.97 µM 0.937557146025966 0.192009272546297 no 680 0.174236021521883 845 6465167
SGTC_428 3448-4153 16.5 µM 0.933223466721303 0.193098314357743 no 681 0.175352300442342 780 3834874
SGTC_2860 9025725 38.96 µM 0.929794454614275 0.193962682555122 no 682 0.176238759032942 819 40546248
SGTC_1427 4048-4900 550 nM 0.929428006906253 0.194055194100342 no 683 0.176333659514281 893 24132586
SGTC_1957 st077035 62.4 µM 0.927920175958085 0.194436136314182 no 684 0.176724488899049 904 705593
SGTC_3301 9125354 19.7965 µM 0.927808185821052 0.194464447934001 no 685 0.176753538545209 794 41905162
SGTC_1360 1598-0022 39.8 µM 0.926017967824846 0.194917363841117 no 686 0.177218321344891 954 761525
SGTC_1340 1486-1359 257 µM 0.925441869156433 0.195063250143922 no 687 0.177368054159396 883 4309068
SGTC_3126 9127922 49.47 µM 0.925385262046193 0.195077588425239 no 688 0.177382771124735 861 45595682
SGTC_409 arachidonic acid 100 µM 0.925111922263663 0.195146832960392 no 689 0.177453846051962 868 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2982 9019404 25.97 µM 0.924314939627053 0.195348815991556 no 690 0.177661183342667 777 22333232
SGTC_483 fpl-64176 144 µM 0.919183819012351 0.196652258410011 no 691 0.178999716588007 843 3423
SGTC_982 1491-0518 27.5 µM 0.916758892254468 0.197270083802576 no 692 0.179634499026314 839 3091256
SGTC_351 caspofungin 25 nM 0.915638475057878 0.197555941028765 no 693 0.179928272166165 989 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_168 3970-0862 530.542 µM 0.91457668514888 0.197827071376712 no 694 0.180206951526273 1003 3135186
SGTC_214 4373-3496 70 µM 0.91221017441711 0.198432173387478 no 695 0.180829044485401 1054 3779166
SGTC_17 0960-0276 49.807 µM 0.909939459826712 0.199013829496054 no 696 0.181427219051292 948 6821114
SGTC_1661 st013063 9.66 µM 0.909467142218579 0.199134945213488 no 697 0.18155179718202 958 721395
SGTC_1074 carmofur 3.8 µM 0.908686833216085 0.199335135964278 no 698 0.181757728143851 961 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_735 3076-0345 636 µM 0.908585713971565 0.19936108729384 no 699 0.181784425164877 937 2888990
SGTC_1297 1068-0111 14.1 µM 0.908552932118891 0.199369500893225 no 700 0.181793080599896 864 767057
SGTC_682 0kpi-0099 17 µM 0.903963858593906 0.200549414479855 no 701 0.183007282911724 919 1714895 YML126C ERG13
SGTC_645 0845-0943 5.41 µM 0.902965777645042 0.200806588825126 no 702 0.183272029078174 868 1885106
SGTC_2348 9022543 33.42 µM 0.902507814816494 0.200924657781225 no 703 0.183393585997389 920 3162678 YDL140C RPO21
SGTC_1349 flufenamic acid 69 µM 0.902334780683484 0.200969279139868 no 704 0.18343952746959 872 3371 A non-steroidal anti-inflammatory.
SGTC_2332 7982454 138.89 µM 0.901534348213912 0.201175768848481 no 705 0.183652139840124 909 2981748
SGTC_3146 9095609 49.47 µM 0.901048417718686 0.201301187678203 no 706 0.183781288479747 895 17173999
SGTC_800 3448-7362 155 µM 0.900548269853191 0.201430324954021 no 707 0.183914274820579 1082 15991913
SGTC_1004 4084-0029 199 µM 0.899073716027469 0.201811340944538 no 708 0.184306698578109 964 716894 YLR208W SEC13
SGTC_1288 0973-0013 65.5 µM 0.898866822647974 0.201864835472496 no 709 0.184361800868299 939 4315430
SGTC_765 1319-0117 244 µM 0.897978865941935 0.202094522703653 no 710 0.184598408366907 887 3487746 YGL099W LSG1
SGTC_1947 st076332 61.6 µM 0.897659418731525 0.202177192158948 no 711 0.184683575354938 891 24208416
SGTC_1866 st057638 64 µM 0.897040750215803 0.202337354349556 no 712 0.184848586412979 898 688802
SGTC_3344 9148862 3.898 µM 0.896522342439309 0.202471619246508 no 713 0.184986926498251 940 4905352
SGTC_3083 9117465 49.47 µM 0.896113987685112 0.202577418484158 no 714 0.185095943585218 941 16420915
SGTC_3209 9113616 49.47 µM 0.893034686884843 0.203376287596554 no 715 0.185919298705689 957 16649353
SGTC_1847 st056231 15 µM 0.892653764349276 0.203475241563685 no 716 0.186021308832998 982 5393180
SGTC_662 k832-1615 104 µM 0.892213843660182 0.203589557477989 no 717 0.186139161690554 892 5878478
SGTC_3338 9144300 39.5675 µM 0.889811308903995 0.204214545382576 no 718 0.186783606586044 915 4901274
SGTC_2706 st078239 82.5 µM 0.88978342064554 0.20422180684915 no 719 0.186791095303495 938 15434492
SGTC_2666 tannic acid 100 µM 0.887048898337248 0.204934560557483 no 720 0.187526287388904 954 16134267 A thiamine antagonist.
SGTC_2474 5321570 43.32 µM 0.885800368413017 0.205260481277531 no 721 0.187862555642466 931 2841384
SGTC_1222 0366-0074 1.18 µM 0.885189739480317 0.205419994107942 no 722 0.188027152662105 989 286520
SGTC_3276 9139060 49.47 µM 0.884916861485119 0.205491301030965 no 723 0.188100736586625 916 4870619
SGTC_39 0986-0283 58.349 µM 0.883697006436493 0.205810246265013 no 724 0.188429898377222 991 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_590 k048-0076 22.4 µM 0.882870852982498 0.2060264203862 no 725 0.188653026633462 917 6832814
SGTC_1355 1499-0035 1.68 µM 0.88232596197891 0.206169072084936 no 726 0.188800280380777 901 1548538
SGTC_2972 9093619 59.92 µM 0.878992916192909 0.207042932581962 no 727 0.189702558360836 885 25236256
SGTC_1737 st035557 69.7 µM 0.877058072365768 0.207551215173331 no 728 0.1902275482163 803 5716916
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.875232039256916 0.208031588943392 no 729 0.190723831821499 923 2724278 An inhibitor of dopamine biosynthesis.
SGTC_774 k060-0086 136 µM 0.874617857793469 0.208193308787042 no 730 0.190890933930696 1009 5911235
SGTC_457 grayanotoxin iii 135 µM 0.871723885570366 0.208956316995159 no 731 0.191679513258542 962 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1057 3448-5381 134 µM 0.871376091946664 0.209048125019419 no 732 0.191774417750933 966 5497911
SGTC_86 0417-1630 471.922 µM 0.869961065615901 0.209421898209435 no 733 0.1921608408875 1047 3634867
SGTC_836 0330-0104 1.35 µM 0.869351911968016 0.209582924556023 no 734 0.192327338470042 943 46494820
SGTC_1048 3161-0300 24.5 µM 0.868175433463731 0.209894126107332 no 735 0.192649150375471 991 2165101
SGTC_3322 9139058 2.11 µM 0.867291683407895 0.210128073797471 no 736 0.192891106153715 935 4908926 YPR165W RHO1
SGTC_3041 9091929 49.47 µM 0.867270521110562 0.210133677791009 no 737 0.192896902306487 1011 25236887
SGTC_13 0199-0087 65 µM 0.866355187775566 0.210376151463384 no 738 0.193147705237483 1009 4589825
SGTC_3158 9100007 49.47 µM 0.860808414979157 0.211849012738352 no 739 0.194671784792818 921 19297233
SGTC_612 0302-0167 22.4 µM 0.858562076373079 0.212447205989258 no 740 0.195291084251992 1027 235821
SGTC_1067 clotrimazole 1.36 µM 0.857752239309414 0.212663104954865 no 741 0.195514643769746 985 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2035 5154463 94.595 µM 0.857605268176604 0.212702300537407 no 742 0.195555232531992 951 2769623
SGTC_1310 1188-0297 994 nM 0.853196657825045 0.213879987956181 no 743 0.196775128243292 952 1588352
SGTC_837 0091-0265 12.5 µM 0.853124439865354 0.213899311343804 no 744 0.19679514978481 966 759367
SGTC_577 r071-0003 38.6 µM 0.851299792405524 0.214387870153794 no 745 0.1973014201059 1085 4568517 YMR134W ERG29
SGTC_584 0986-0246 15.4 µM 0.844235761164018 0.216285410089165 no 746 0.199268837403542 1090 53315 YDR232W HEM1
SGTC_3097 9117246 49.47 µM 0.843072516364641 0.216598810628799 no 747 0.199593944260055 1015 16423892
SGTC_1396 3511-0007 98.6 µM 0.842672189182463 0.216706727208392 no 748 0.199705902588157 897 X1396
SGTC_1807 st050092 58.9 µM 0.841626554943781 0.216988746462404 no 749 0.199998510222129 935 5008496
SGTC_1215 3852-0577 11.2 µM 0.841206191448744 0.217102182951169 no 750 0.200116216283269 1049 2884876
SGTC_2737 bleomycin 30.5 nM 0.84045297957978 0.217305525359189 no 751 0.200327227400132 1040 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2444 5485484 36.41 µM 0.840051700025807 0.217413902520412 no 752 0.200439699792914 1019 6790631
SGTC_1260 0700-1617 7.75 µM 0.839401569513467 0.217589555307149 no 753 0.200622001707129 971 2853078
SGTC_2937 9044753 11.33 µM 0.839394103324652 0.217591573003627 no 754 0.200624095865568 1034 6465530 YGL099W LSG1
SGTC_549 1661-1316 519 µM 0.839292327478752 0.217619078443203 no 755 0.200652643833445 1022 2857282
SGTC_1943 st076331 65.2 µM 0.837416269318291 0.218126451944747 no 756 0.201179311949766 1054 24208415
SGTC_1068 loratadine 26.9 µM 0.837345909270826 0.218145493833678 no 757 0.201199080326314 947 3957 A H1 histamine antagonist.
SGTC_65 0798-0905 34.986 µM 0.83646080357146 0.218385116199887 no 758 0.201447859317122 1040 3602145
SGTC_1879 gemcitabine 100 µM 0.836193876952181 0.218457410294475 no 759 0.201522921249839 980 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1986 st071812 45 µM 0.835768345032086 0.218572689359014 no 760 0.201642618928404 958 11838594
SGTC_3173 9105693 49.47 µM 0.833200963448648 0.219268950605275 no 761 0.202365699664216 1032 17096658
SGTC_2236 dapsone 200 µM 0.833188069329622 0.219272450641094 no 762 0.202369335089982 1063 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3026 9090633 49.47 µM 0.832250465630007 0.219527043921466 no 763 0.202633791948181 1026 25236842
SGTC_210 3551-0445 56.827 µM 0.830681850153957 0.219953359133491 no 764 0.203076691100137 993 2865180 YOR207C RET1
SGTC_347 4534-1311 26.2 µM 0.825752877545908 0.221296032971567 no 765 0.20447214497181 1010 2862016
SGTC_2119 5528445 120.635 µM 0.825483562202965 0.221369530469819 no 766 0.204548555593584 993 791935
SGTC_2365 9042475 200 µM 0.824283562630061 0.221697185940031 no 767 0.204889228051502 1017 6464479
SGTC_2779 methotrexate 400 µM 0.82350548917551 0.221909784034803 no 768 0.205110298472564 1101 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_661 1304-0007 33.6 µM 0.822480685261221 0.222189975483436 no 769 0.205401687492308 960 3117130
SGTC_877 0771-0151 33.1 µM 0.822044581258676 0.222309271809714 no 770 0.20552576225366 1014 6166523
SGTC_108 0509-0257 621.132 µM 0.82163383906082 0.222421663818587 no 771 0.205642662079973 1016 536624
SGTC_766 1391-0721 126 µM 0.821503545094216 0.222457323123388 no 772 0.205679752810517 1015 1020919 YIL115C NUP159
SGTC_2570 licareol 100 µM 0.819380691941263 0.223038772064305 no 773 0.206284623718614 943 443158
SGTC_3318 9139014 38.6185 µM 0.819262846054432 0.223071075359382 no 774 0.206318232759779 978 16643984
SGTC_3259 9138485 49.47 µM 0.819243613730088 0.223076347475905 no 775 0.20632371802783 1088 17646153
SGTC_356 1634-0012 32.5 µM 0.818937587958656 0.223160247221756 no 776 0.206411011534282 1044 735457
SGTC_596 1155-0152 116 µM 0.818141848272885 0.223378490554625 no 777 0.20663809779023 1022 280313
SGTC_170 4197-0004 226 µM 0.816407863065673 0.223854481961508 no 778 0.207133450451855 942 218692
SGTC_3188 9110789 49.47 µM 0.816375968649705 0.223863242603709 no 779 0.207142568397615 1014 849217
SGTC_576 1073-0113 22.7 µM 0.814470933185417 0.224386864095391 no 780 0.207687608632701 1219 5439563
SGTC_1351 1496-0003 46.5 µM 0.812338123954844 0.224973915838704 no 781 0.208298820232524 1048 3891978
SGTC_801 0866-0028 10.1 µM 0.812089110835057 0.225042512936096 no 782 0.208370250491215 1051 6849771
SGTC_3282 9108498 15.4605 µM 0.805377631793165 0.226895822273871 no 783 0.210300897790255 972 16459645
SGTC_1342 1486-1464 234 µM 0.805336792747016 0.226907125866294 no 784 0.21031267775263 1055 3253938
SGTC_1697 st025554 27.742 µM 0.804822875914942 0.227049396940246 no 785 0.210460949413876 1031 1269519
SGTC_2513 baicalein 25.65 µM 0.804566437120779 0.227120407432717 no 786 0.210534958268091 1045 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2145 5634607 200 µM 0.804224493012056 0.227215114685051 no 787 0.210633667919987 984 308662
SGTC_676 falcarinol 140 µM 0.803928994139724 0.227296976062148 no 788 0.210718992005874 1090 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1669 st015249 58.4 µM 0.802982261148679 0.227559359222732 no 789 0.210992493772661 1133 722793
SGTC_532 1548-0774 215 µM 0.798310744478983 0.228856545083389 no 790 0.212345092218016 1064 5932993
SGTC_1458 k015-0034 6.33 µM 0.796337792598441 0.229405638056591 no 791 0.212917862384054 1013 3598957
SGTC_3023 9089636 49.47 µM 0.796066925232564 0.229481080858782 no 792 0.212996568561329 1138 17249241
SGTC_2866 9034245 58.44 µM 0.793360512830602 0.23023564206957 no 793 0.213783904964141 1064 6462273
SGTC_2455 5377712 9.75 µM 0.790797141369471 0.230951600556291 no 794 0.214531189172138 972 2243908
SGTC_1262 0737-0114 49.6 µM 0.787090148266248 0.231989171498752 no 795 0.215614548039158 1104 765919
SGTC_1133 3473-0247 50 µM 0.785922172337885 0.232316619696928 no 796 0.215956541983026 989 711311
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.785853444612179 0.232335895883687 no 797 0.215976675870457 1104 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3286 9117135 37.221 µM 0.785653023885648 0.232392113319616 no 798 0.216035395623771 1054 3438150
SGTC_996 3970-0799 1.8 µM 0.782911915972438 0.233161745118985 no 799 0.216839419781391 1209 6615648 YGL040C HEM2
SGTC_1087 pterostilbene 9.05 µM 0.779908952116089 0.234006520940426 no 800 0.21772223438739 1080 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2303 7774051 200 µM 0.779547524811184 0.234108309689274 no 801 0.217828626807008 1042 2953184
SGTC_1281 0884-0031 11.8 µM 0.77815146118801 0.234501713173005 no 802 0.218239863944963 1094 1548255
SGTC_225 nsc-122657 1.016 µM 0.77721719609979 0.234765188358478 no 803 0.218515319203165 962 275685
SGTC_343 4130-2827 29.8 µM 0.776901210028726 0.234854337656635 no 804 0.218608528651759 1075 1118244
SGTC_1962 st076595 64.5 µM 0.776418297900357 0.234990618022515 no 805 0.218751022094741 1087 279619
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.776159540736077 0.235063658641983 no 806 0.218827395860324 1062 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1050 3232-1156 69.3 µM 0.774802802373485 0.235446836847706 no 807 0.219228096553678 1018 700529
SGTC_2762 leflunomide 42.06 µM 0.774777250133735 0.235454056770461 no 808 0.219235647226302 1068 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2943 9068529 45.32 µM 0.773247019920884 0.235886654218508 no 809 0.219688101861351 1162 3270634
SGTC_2946 9065502 71.43 µM 0.773183952837152 0.235904492734833 no 810 0.219706760875348 914 16489101
SGTC_2488 5268135 45.7 µM 0.772416889899572 0.236121515894793 no 811 0.219933776776943 1091 1270356 YLR208W SEC13
SGTC_1244 0416-0015 52.5 µM 0.772360524706154 0.236137467491912 no 812 0.219950463629531 1058 96201
SGTC_2088 5278280 127.392 µM 0.771075565530785 0.23650127755436 no 813 0.220331071371094 1119 791502
SGTC_2311 7694451 200 µM 0.770971628593702 0.236530718663391 no 814 0.220361874217886 1022 2163142
SGTC_3208 9114115 49.47 µM 0.769924768480015 0.23682736400545 no 815 0.220672260263163 1010 650895
SGTC_1787 fluconazole 80 µM 0.769370738431396 0.236984440439551 no 816 0.220836627233823 1035 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1171 0368-0077 21.4 µM 0.766536218822623 0.237788967577966 no 817 0.221678654846977 1041 3239779
SGTC_2465 5809242 33.21 µM 0.759315886324535 0.239845079842099 no 818 0.223831808283645 1115 2731748
SGTC_3130 9127414 49.47 µM 0.759138874866127 0.239895608364893 no 819 0.223884743182009 1132 1494646
SGTC_1228 0124-0032 52.5 µM 0.759093409372676 0.239908587581722 no 820 0.223898340688921 1126 X1228
SGTC_1076 itraconazole 331 nM 0.757992646173388 0.240222943727088 no 821 0.224227692567381 1147 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_29 0299-0004 12.984 µM 0.757748347084321 0.240292741128125 no 822 0.224300824921557 1018 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2416 tofa 880 nM 0.755625334218613 0.240899760898281 no 823 0.224936931051855 1014 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_980 1473-0395 201 µM 0.754320555495717 0.241273241568418 no 824 0.225328381174608 1053 768876
SGTC_522 1273-0010 11.6 µM 0.753473813858056 0.241515781676404 no 825 0.225582620636745 1129 5705015
SGTC_1504 k297-0033 30 µM 0.751735646994308 0.242014075638958 no 826 0.226105024400336 1024 4388117
SGTC_1182 1222-0449 220 µM 0.750096932993641 0.242484368835037 no 827 0.22659816328515 1074 658318
SGTC_1392 3455-1037 33.9 µM 0.749851826864601 0.242554754177314 no 828 0.226671975333639 1105 981132
SGTC_118 0083-0097 135.343 µM 0.749183406679175 0.242746755751243 no 829 0.226873334482848 1208 5207356
SGTC_1860 st056228 74.6 µM 0.748424569794154 0.242964828908476 no 830 0.227102053579039 1120 688679
SGTC_46 0329-0187a 2.197 µM 0.748055393656012 0.243070960381453 no 831 0.227213373007056 1134 46494817
SGTC_2807 7945238 51.95 µM 0.745427614970953 0.243827123157687 no 832 0.228006627476056 1104 17148797
SGTC_151 3013-0144 2.285 µM 0.744044984647158 0.244225494422416 no 833 0.228424630367114 1094 906558 YHR107C CDC12
SGTC_235 0330-0087 5 mM 0.744027594388282 0.244230507235637 no 834 0.228429890607264 1154 46494818 YHR062C RPP1
SGTC_1675 st018485 24.5 µM 0.743895073149123 0.244268708846514 no 835 0.228469978131176 1105 3323024
SGTC_2477 5967686 25.23 µM 0.743584566153471 0.244358230640375 no 836 0.228563921621688 1124 776118
SGTC_2759 disulfiram 3.38 µM 0.742099621128575 0.244786597221872 no 837 0.229013489687408 1109 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1359 1582-0056 520 nM 0.741236911319784 0.245035651249492 no 838 0.229274903311665 1142 3661189
SGTC_563 tetrahydrosecaminediol 614 µM 0.741216533038386 0.245041535863673 no 839 0.229281080249399 1159 334274 A psychoactive constituent of the cannabis plant.
SGTC_62 0180-0423 3.232 µM 0.740759969098937 0.245173397265533 no 840 0.229419495526878 1122 30102 YGL099W LSG1
SGTC_273 hydroxyurea 18.1 mM 0.739221746872638 0.245617935863015 no 841 0.229886178802682 1200 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_395 anisomycin 6.25 µM 0.738370699983776 0.245864070080331 no 842 0.230144607222277 1057 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1445 4239-0156 97.7 µM 0.738366947933659 0.245865155516769 no 843 0.230145746927435 1173 4008346
SGTC_2058 5236698 133 µM 0.737812286436207 0.246025642697033 no 844 0.230314263033914 1103 766665
SGTC_2809 7964133 12.99 µM 0.736558679177744 0.24638857159316 no 845 0.230695385478357 1119 1253665
SGTC_217 ketoconazole 989 nM 0.736531117223797 0.246396554212211 no 846 0.230703768836898 1089 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1534 6-azauridine 81.6 µM 0.735562071466778 0.246677301758129 no 847 0.230998625982244 1179 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1236 0330-0013 258 µM 0.735449763634927 0.246709850148181 no 848 0.231032812132163 1116 4617066
SGTC_145 3737-0113 38.366 µM 0.734449735443512 0.246999773771152 no 849 0.231337342054811 1210 6849351
SGTC_829 1635-0120 117 µM 0.732659856129015 0.247519142238352 no 850 0.23188295703386 1169 285054
SGTC_799 1310-0557 151 µM 0.730039818123781 0.248280448428106 no 851 0.232682922967722 1139 5354492
SGTC_793 0488-0545 106 µM 0.729830997713116 0.248341179185882 no 852 0.232746747218192 1125 292548
SGTC_506 n9-isopropylolomoucine 153 µM 0.729519981721569 0.248431645926946 no 853 0.232841824745469 1146 6610355
SGTC_1486 3970-0793 4.53 µM 0.727730663957454 0.248952454535818 no 854 0.23338923780981 1165 2844330
SGTC_2255 7941087 197.44 µM 0.725753113897355 0.249528726316917 no 855 0.233995067263867 1168 935561
SGTC_903 1134-0042 114 µM 0.72477814787968 0.24981309880196 no 856 0.234294071860633 1162 701009
SGTC_501 nsc-95397 161 µM 0.7234994124468 0.250186333666322 no 857 0.234686557470361 1145 262093
SGTC_1497 4476-2978 41.3 µM 0.723228554222353 0.250265429188664 no 858 0.23476973932794 1194 1528379
SGTC_2054 5233173 129 µM 0.721886726841564 0.250657462624336 no 859 0.235182061221741 1150 6889
SGTC_663 1486-0733 13.9 µM 0.720029698117405 0.25120055537349 no 860 0.235753355274122 1143 722445 YPR165W RHO1
SGTC_2269 7935389 174.42 µM 0.720028497264298 0.251200906767246 no 861 0.235753724950519 1087 97605
SGTC_160 3453-0671 289.699 µM 0.719842111834818 0.251255450041443 no 862 0.235811106612575 1159 5322268
SGTC_3200 9114385 49.47 µM 0.719559229488662 0.251338243847711 no 863 0.235898211065841 1152 17018030 YLR208W SEC13
SGTC_1042 0350-0096 82 µM 0.719270883060772 0.251422651718574 no 864 0.235987016255057 1140 3122515
SGTC_231 b-estradiol 524 µM 0.717449703199898 0.251956113045959 no 865 0.236548330269674 1123 450 A steroid.
SGTC_432 NS 1619 61.3 µM 0.716309872961151 0.252290296615737 no 866 0.236900015921536 1125 4552 A K+/calcium channel activator.
SGTC_2711 st079103 59.1 µM 0.716107952987303 0.252349521312643 no 867 0.236962346698265 1157 54693780
SGTC_2071 5230951 39.92 µM 0.713408505149719 0.253141993732257 no 868 0.23779650582346 1223 1799272
SGTC_2657 nystatin 74.44 µM 0.713012643393332 0.253258316163262 no 869 0.237918966730424 1187 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_956 1185-0240 191 µM 0.70741295977208 0.254906767230523 no 870 0.239654942758554 1170 1416193
SGTC_630 4356-0227 183 µM 0.705852615476954 0.255367104205677 no 871 0.240139898797571 1191 779312
SGTC_1495 4469-0029 237 µM 0.70563857694105 0.255430284301849 no 872 0.240206463811004 1215 793680
SGTC_2189 6047310 154.431 µM 0.705386855857313 0.255504598018426 no 873 0.240284760791027 1133 711535
SGTC_1741 st038134 10.228 µM 0.704694559243011 0.255709037761792 no 874 0.24050016897413 1222 1272587
SGTC_68 0986-0284 82.829 µM 0.704323125016488 0.255818759927166 no 875 0.240615784113338 1133 423278 YIL048W NEO1
SGTC_72 0744-0168 198.391 µM 0.702814161868705 0.256264762234183 no 876 0.241085785214558 1117 677577
SGTC_1344 1488-0097 29.1 µM 0.701728975686119 0.256585759724176 no 877 0.241424099604823 1167 747966
SGTC_1441 4106-0040 13 µM 0.700160930244929 0.257049956366607 no 878 0.24191340395163 1190 2904180
SGTC_1129 3453-1384 223 µM 0.69997155678544 0.257106047123036 no 879 0.241972533817113 1245 1084452
SGTC_2476 5806916 10.51 µM 0.699362611717164 0.257286454438613 no 880 0.242162723614711 1121 2870194
SGTC_2822 7994718 71.43 µM 0.698051201832224 0.257675198734723 no 881 0.242572586978389 1144 1018011
SGTC_2290 7904846 200 µM 0.697463893796774 0.257849394643148 no 882 0.242756263854566 1221 2962154
SGTC_1979 st071809 45.3 µM 0.695108780661118 0.258548535938245 no 883 0.243493566211678 1232 4976333
SGTC_947 3447-0010 211 µM 0.695089697476406 0.258554204998914 no 884 0.243499545416322 1214 748350
SGTC_616 4092-0450 108 µM 0.694711719505279 0.258666504553826 no 885 0.243617991028098 1226 787165
SGTC_2741 miltefosine 3.04 µM 0.693199736027503 0.259115976444138 no 886 0.244092106911064 1110 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_3005 9076496 71.4286 µM 0.692901823468002 0.259204585405491 no 887 0.24418558263749 1209 21368410
SGTC_421 streptovitacin 30 mM 0.69245215197528 0.259338362104504 no 888 0.244326712158542 1217 91467 include heat shock
SGTC_128 0906-2981 13.371 µM 0.691904977149783 0.259501194022554 no 889 0.244498502405276 1178 6740226
SGTC_482 fipronil 114 µM 0.691778293164171 0.259538901010098 no 890 0.244538285207962 1222 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1040 k898-0338 155 µM 0.691342788947261 0.259668548696502 no 891 0.244675073983391 1247 20969351
SGTC_3155 9099265 49.47 µM 0.690861296917181 0.259811925653461 no 892 0.244826355148154 1153 25236499
SGTC_1072 oxiconazole 14.9 nM 0.690605038670385 0.25988824995971 no 893 0.244906890079766 1210 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3069 9117009 49.47 µM 0.690595039630073 0.259891228321976 no 894 0.244910032792576 1080 41904981
SGTC_1122 capsaicin 818.572 nM 0.689838942534479 0.260116494034536 no 895 0.245147738053845 1229 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3106 9121286 49.47 µM 0.689034695243109 0.260356215669245 no 896 0.245400717105939 1231 15943471
SGTC_2200 6600604 21.907 µM 0.688575630145807 0.260493100003431 no 897 0.245545180653584 1175 2904777
SGTC_2066 5222451 176 µM 0.687410491043392 0.260840688268651 no 898 0.245912044200217 1224 2281147
SGTC_1909 st060837 51.5 µM 0.68713487052306 0.260922947202106 no 899 0.245998870935947 1170 678937
SGTC_976 1348-1067 47.6 µM 0.685651669061252 0.261365837575825 no 900 0.246466395428712 1261 5310671 YGL099W LSG1
SGTC_2151 5563267 85.4165 µM 0.684887672281964 0.261594120894572 no 901 0.246707402859628 1210 5310824
SGTC_472 calcifediol 10 µM 0.684795072290191 0.261621796855298 no 902 0.2467366226627 1201 5283731 A vitamin D metabolite.
SGTC_1117 retinoic acid 1.10837 µM 0.68435285997038 0.261753984442958 no 903 0.246876187717223 1227 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1263 0774-1208 64.8 µM 0.683562101284205 0.261990446067298 no 904 0.24712586154625 1252 906585
SGTC_1051 3253-3903 78 µM 0.682513709917829 0.26230411669411 no 905 0.247457088330145 1207 5509239
SGTC_1831 st055328 12 µM 0.682246994846778 0.262383946471527 no 906 0.247541391623516 1225 1103068
SGTC_2389 9091542 195.52 µM 0.681531824077284 0.262598063717211 no 907 0.247767518496051 1211 3626624 YOL127W RPL25
SGTC_2175 5807670 165.306 µM 0.678490068161261 0.263509742522636 no 908 0.248730509478501 1185 241186
SGTC_1856 st057054 55.7 µM 0.678313632325522 0.263562673611062 no 909 0.248786428477897 1282 1266018
SGTC_119 0121-0043 24.815 µM 0.678167675469312 0.263606465047461 no 910 0.248832692627135 1290 1092378
SGTC_608 k048-0125 159 µM 0.677921910964341 0.263680210160482 no 911 0.248910603294114 1244 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1750 st081859 2.357 µM 0.677289192878553 0.263870114574032 no 912 0.24911124319764 1239 5291695
SGTC_245 methotrexate 289.6 µM 0.676089689524703 0.264230325579457 no 913 0.249491851212336 1231 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1313 1220-0047 237 µM 0.675397536707257 0.26443829303726 no 914 0.249711615050373 1244 3528706
SGTC_3210 9128157 49.47 µM 0.674982995465403 0.264562887904486 no 915 0.249843284285411 1204 17590849
SGTC_3336 9143619 71.43 µM 0.672728877955406 0.265240909717016 no 916 0.250559896082071 1253 45595730
SGTC_98 0074-0023 107.663 µM 0.668405840915298 0.26654371101391 no 917 0.251937284038343 1214 3563821
SGTC_524 r073-0010 27.8 µM 0.668055787683348 0.266649345393492 no 918 0.252048991162964 1185 2772106
SGTC_804 1595-0054 20.9 µM 0.668030902366742 0.266656855757016 no 919 0.252056933427546 1238 761523 Stimulates phospholipase C.
SGTC_1198 1612-1005 86.7 µM 0.667579856835121 0.266792999377441 no 920 0.252200909589088 1297 6998509
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.662126255563948 0.268441889887365 no 921 0.25394515521536 1232 521171
SGTC_1409 3909-8004 61.9 µM 0.661337712136037 0.268680728470024 no 922 0.254197880817723 1255 2119279
SGTC_1732 st034308 51.822 µM 0.658150475581227 0.269647183719289 no 923 0.255220722125594 1191 830119
SGTC_2408 sulbentine 18.36 µM 0.658049399173131 0.269677861252073 no 924 0.255253194524023 1247 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1722 st034304 3.6505 µM 0.657700500570875 0.269783768318397 no 925 0.255365300325465 1274 4036148 YLR033W RSC58
SGTC_841 0251-0215 91.2 µM 0.653308690203721 0.271118666930501 no 926 0.256778645554859 1298 3888614
SGTC_1369 1866-0067 208 µM 0.651188649990412 0.271764233666852 no 927 0.257462358071114 1294 3531355
SGTC_1357 1503-1303 39.5 µM 0.650729941658991 0.271904014093194 no 928 0.257610415765374 1268 292895
SGTC_2438 5259590 200 µM 0.650274918390587 0.272042706911135 no 929 0.257757327698531 1268 1201127
SGTC_2281 7943571 200 µM 0.650040375432333 0.272114210231287 no 930 0.257833070828327 1313 1244024
SGTC_2986 9022445 71.43 µM 0.648195333079976 0.272677019829207 no 931 0.258429310012198 1241 6459286
SGTC_786 4544-0069 423 µM 0.647809984650166 0.272794638955154 no 932 0.258553928338644 1310 748821 YLR208W SEC13
SGTC_2289 7946404 165.07 µM 0.641387563156871 0.274758639086606 no 933 0.260635455629737 1319 1246120 YPR165W RHO1
SGTC_2567 aureobasidin a 60 nM 0.64104316984415 0.274864152443724 no 934 0.260747317772609 1355 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1766 st045414 44.774 µM 0.640306916267628 0.275089788786204 no 935 0.260986542595374 1312 253960
SGTC_1214 0358-0031 63.7 µM 0.640171456933589 0.275131312336676 no 936 0.261030568571921 1389 4301366
SGTC_2843 9000894 45.46 µM 0.639223487701349 0.275421988100582 no 937 0.2613387772448 1155 2242070
SGTC_1748 st037455 53.6035 µM 0.63851645289709 0.275638884475383 no 938 0.261568773707161 1286 580690
SGTC_116 0155-0182 31.788 µM 0.638251489385951 0.275720188699268 no 939 0.26165499235965 1259 771486
SGTC_1765 st044815 90.4 µM 0.637923094982272 0.27582097308903 no 940 0.261761871546765 1244 645695
SGTC_2806 7952793 58.44 µM 0.635831307963384 0.276463368018415 no 941 0.262443189498138 1314 2972490
SGTC_1908 st060353 56.5 µM 0.634444010485641 0.276889816058273 no 942 0.262895547709441 1336 4227716
SGTC_968 1309-0633 340 µM 0.634441391868429 0.276890621312094 no 943 0.262896401942768 1270 3761976
SGTC_1691 st019933 84.6 µM 0.633234970449665 0.277261731191268 no 944 0.263290106101834 1282 6176082
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.633098310199167 0.277303784878822 no 945 0.263334722853726 1394 6728940
SGTC_1275 0867-0008 21.1 µM 0.632767778416262 0.27740551045317 no 946 0.263442650619246 1293 3422836
SGTC_2093 5331342 194.4 µM 0.632389676900533 0.277521898615123 no 947 0.263566138900085 1292 33839
SGTC_2775 cyproheptadine 69.59 µM 0.631423363336316 0.277819460078997 no 948 0.263881871894024 1300 2913 A selective serotonin reuptake inhibitor.
SGTC_3140 9094243 49.47 µM 0.630215742376016 0.278191547298374 no 949 0.264276720466567 1310 19291112
SGTC_839 0122-0028 230 µM 0.629876477541101 0.278296123897596 no 950 0.264387701957592 1292 759448
SGTC_1698 5-fluorocytosine 1.055 µM 0.629113075759821 0.278531508531307 no 951 0.264637515320048 1322 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_943 3253-1379 105 µM 0.628240962102714 0.278800531627382 no 952 0.264923050089671 1317 668464
SGTC_2083 5306046 65.942 µM 0.628172182465216 0.278821753634208 no 953 0.264945575577319 1306 539837
SGTC_1334 1486-0610 236 µM 0.627408594845817 0.279057411942568 no 954 0.265195717624265 1300 3742339
SGTC_26 0302-0163 425.158 µM 0.626192003989563 0.279433076024945 no 955 0.265594505632382 1307 3100915
SGTC_2558 carylophyllene oxide 100 µM 0.625841366399725 0.279541392966183 no 956 0.265709498050995 1352 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1676 st018489 23.4 µM 0.625726019973672 0.279577029574202 no 957 0.265747331698479 1329 3696235
SGTC_2635 hydroquinidine 100 µM 0.623339711482314 0.280314780776002 no 958 0.266530653469886 1332 442912 An experimental heart treatment.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.621836545364597 0.280779983154404 no 959 0.267024676594997 1372 94937 An inhibitor of serotonin biosynthesis.
SGTC_2232 chlorophetanol 41.5365 µM 0.620346350328457 0.28124153942148 no 960 0.267514892738864 1369 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2264 7948757 110.76 µM 0.617625787421208 0.282085119702596 no 961 0.268411020944067 1284 2971411
SGTC_2089 5281248 129.67 µM 0.617031567523584 0.28226953480324 no 962 0.268606952140413 1327 2737878
SGTC_2658 polymyxin b sulfate 77.05 µM 0.616433863315093 0.28245508976083 no 963 0.268804104698068 1289 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_201 4262-0159 12.803 µM 0.615845176434741 0.282637902644544 no 964 0.268998353910309 1289 1341029
SGTC_3077 9117319 49.47 µM 0.613005177713203 0.283520643819658 no 965 0.269936458072058 1326 17154678
SGTC_2435 5706476 10.6 µM 0.612575547339231 0.283654298430737 no 966 0.270078515399626 1346 5725375
SGTC_50 0929-0078 56.389 µM 0.612312065338953 0.283736280524191 no 967 0.270165654248675 1299 1377751
SGTC_2841 9004761 38.96 µM 0.611640583243055 0.283945262625902 no 968 0.27038779057969 1235 2991039
SGTC_3214 9129694 49.47 µM 0.610267403322681 0.284372859914797 no 969 0.270842343101087 1325 17158655
SGTC_402 epigallocatechin gallate 10 µM 0.608690976612769 0.284864125703507 no 970 0.271364644570611 1310 65064 An antioxidant.
SGTC_1452 4194-0072 190 µM 0.60734320865644 0.285284454785657 no 971 0.271811584484189 1417 1343545
SGTC_2871 9038510 12.99 µM 0.604336694411307 0.286223161180723 no 972 0.272809907446556 1383 4945164
SGTC_1545 lovastatin 49.4 µM 0.603734375421033 0.286411395946024 no 973 0.273010127931215 1378 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.60312000517001 0.286603457438263 no 974 0.273214429469412 1372 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1170 0310-0127 64.8 µM 0.602592568538232 0.286768390873961 no 975 0.273389882668753 1364 774975
SGTC_165 k038-0023 64.381 µM 0.602330746425265 0.286850281342181 no 976 0.273476999208154 1310 46368543
SGTC_2469 5655019 90.81 µM 0.601090708545484 0.287238280182659 no 977 0.273889785799931 1437 2788239
SGTC_868 0527-0199 213 µM 0.601087202928043 0.287239377416875 no 978 0.273890953194225 1344 2849450
SGTC_490 phenamil 164 µM 0.600954487216243 0.287280917983437 no 979 0.273935150232233 1330 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1444 4112-3581 28 µM 0.600360403778031 0.287466903392408 no 980 0.274133035330774 1360 2877249
SGTC_1770 st043884 66.3 µM 0.600016810029869 0.287574495787585 no 981 0.274247516262794 1331 670149
SGTC_1952 st077036 64.1 µM 0.598802370159955 0.287954936015741 no 982 0.274652340801769 1335 2937007
SGTC_908 3448-7491 47.7 µM 0.596027964428221 0.288824947649096 no 983 0.275578272685269 1344 1203031
SGTC_1874 staurosporine 7.6 µM 0.595531078813657 0.28898089400574 no 984 0.275744265530895 1388 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_433 pimozide 108 µM 0.594308450938729 0.289364781390992 no 985 0.276152913665951 1293 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2461 5755302 26.15 µM 0.594219622140314 0.289392681676912 no 986 0.276182615164417 1417 2788904
SGTC_1678 st019265 80.2 µM 0.592193811568683 0.290029312432701 no 987 0.27686040647106 1409 5367020
SGTC_3227 9130768 49.47 µM 0.592025114598647 0.290082356701929 no 988 0.276916885459706 1377 17720899
SGTC_1201 1889-3372 45.9 µM 0.591768300260687 0.290163116904089 no 989 0.277002876577746 1295 5392199
SGTC_3031 9088762 49.47 µM 0.591567366477929 0.29022631173727 no 990 0.27707016589346 1306 205253
SGTC_1633 st005664 67.9 µM 0.591183074320142 0.290347191790652 no 991 0.277198881095555 1345 2063822
SGTC_805 3852-0218 479 µM 0.588667332550063 0.291139106356105 no 992 0.27804222801209 1314 6615355
SGTC_2028 5153890 36.43 µM 0.587183631212965 0.291606623744419 no 993 0.278540192302675 1321 2830968 YPR165W RHO1
SGTC_441 propafenone 146 µM 0.586109693763309 0.291945241891148 no 994 0.278900901221776 1312 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_3356 9151811 4.48 µM 0.586015415006045 0.291974977221813 no 995 0.278932577963257 1345 1859254 YPR165W RHO1
SGTC_2847 9005661 71.43 µM 0.585260655241807 0.292213077754326 no 996 0.279186232944649 1277 2991449
SGTC_3191 9110352 49.47 µM 0.584895169720361 0.292328408216092 no 997 0.279309103333019 1389 17122424
SGTC_1531 st059297 52.4 µM 0.584598193918185 0.292422135739317 no 998 0.27940896119401 1381 7566702
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.581333959904859 0.293453269031391 no 999 0.280507698459647 1415 551469
SGTC_1867 st057372 64 µM 0.580660757801006 0.293666135006763 no 1000 0.280734557322882 1366 688837
SGTC_665 3914-0008 307 µM 0.580075698215517 0.293851188414788 no 1001 0.280931785538838 1311 1069549
SGTC_427 1354-0053 47.3 µM 0.578851004026219 0.294238731755876 no 1002 0.281344856331082 1449 6813657
SGTC_341 1486-1430 230 µM 0.575719596676419 0.295230709184304 no 1003 0.282402363669593 1331 2054753 YPL210C SRP72
SGTC_734 2023-0417 80 µM 0.575303641639448 0.295362592519668 no 1004 0.282542979535922 1396 3935732
SGTC_2314 7727897 200 µM 0.574462042935954 0.295629513953239 no 1005 0.282827589474799 1349 900724
SGTC_2789 5281112 71.43 µM 0.574234397949517 0.295701732881941 no 1006 0.282904597594319 1346 765948
SGTC_286 k060-0067 22.9 µM 0.572828641360547 0.296147879752901 no 1007 0.283380362170411 1339 5985051
SGTC_622 1348-1566 26.3 µM 0.571959470712023 0.296423884038225 no 1008 0.283674716265406 1450 7340407
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.569170082778193 0.297310446774357 no 1009 0.284620360701565 1380 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_202 3594-0513 34.79 µM 0.569015417264313 0.297359640187875 no 1010 0.284672838647149 1369 708429
SGTC_1859 st055998 20 µM 0.568042970896808 0.297669024774472 no 1011 0.285002895078107 1472 676301
SGTC_2417 cerulenin 830 nM 0.566026646551319 0.298310987535274 no 1012 0.285687833279071 1446 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_3225 9130819 49.47 µM 0.563190109973999 0.299215157093699 no 1013 0.286652718353055 1424 4547121
SGTC_2010 4012422 159 µM 0.562736283877998 0.299359933246068 no 1014 0.286807236532634 1430 952393
SGTC_2643 anethole 100 µM 0.562395261532999 0.299468744504585 no 1015 0.286923373394831 1387 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_359 0081-0058 15.9 µM 0.557341428015019 0.30108338702181 no 1016 0.288647087837808 1548 3494159
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.5568825712134 0.301230180657151 no 1017 0.288803831657828 1312 88881 An O-methylated flavonoid and antioxidant.
SGTC_3008 9078912 71.4286 µM 0.556574053582625 0.30132889716111 no 1018 0.288909242684589 1373 16648731
SGTC_1157 4092-0394 27.6 µM 0.556242983523617 0.301434845973457 no 1019 0.289022379320487 1505 3659885
SGTC_723 4182-0001 115 µM 0.555764772491445 0.301587912331639 no 1020 0.289185835253148 1352 744821 YLR208W SEC13
SGTC_1921 5740136 50 µM 0.555584987286408 0.301645467236678 no 1021 0.289247298354256 1502 1774243
SGTC_2463 5473429 200 µM 0.553859151771173 0.302198212642708 no 1022 0.289837621246701 1409 5399405
SGTC_1376 2910-0861 41.3 µM 0.551129116649571 0.303073507056395 no 1023 0.290772583464805 1456 1112859
SGTC_2896 9052656 71.43 µM 0.550811710080171 0.303175346408873 no 1024 0.290881377963654 1361 6469436
SGTC_1062 mesoridazine 14.2 µM 0.548604901432028 0.303883819807879 no 1025 0.291638310715746 1418 4078 A neuroleptic.
SGTC_1181 1222-0449 220 µM 0.546967747761856 0.304409887886031 no 1026 0.292200445081298 1460 658318
SGTC_1990 st072050 59.8 µM 0.546078557549062 0.304695781957772 no 1027 0.292505969235743 1393 17233948
SGTC_1888 azatryptophan 97.5 µM 0.545950378527126 0.304737004156367 no 1028 0.292550023557697 1399 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2114 5491910 81.25 µM 0.545376690496018 0.304921531817983 no 1029 0.292747234289082 1494 2849228
SGTC_2459 5811157 9.22 µM 0.545340522098884 0.304933167103394 no 1030 0.292759669588955 1381 2870684 YBR192W RIM2
SGTC_21 0849-0113 22.993 µM 0.543636703158353 0.305481504842147 no 1031 0.293345748770913 1382 1560156
SGTC_3144 9087057 49.47 µM 0.542969945880328 0.30569620537351 no 1032 0.29357524768118 1404 17249618
SGTC_54 0159-0055 9 µM 0.542031382137773 0.305998542709795 no 1033 0.293898443609646 1510 3319099
SGTC_900 1112-0045 141 µM 0.541898331609774 0.306041412669175 no 1034 0.293944273086296 1356 56211 YIL048W NEO1
SGTC_2149 5554786 194.827 µM 0.541590630023467 0.306140566792455 no 1035 0.294050274068531 1423 745063 YPR165W RHO1
SGTC_1284 0929-0043 16 µM 0.541399957171614 0.306202016566117 no 1036 0.294115968359825 1407 1239883
SGTC_1191 1487-1166 10.6 µM 0.539306773619878 0.306876962949964 no 1037 0.294837597877881 1522 3955771
SGTC_1974 st069448 26.9 µM 0.539050147269521 0.306959757167074 no 1038 0.294926126498456 1454 6323587 YNR016C ACC1
SGTC_1368 1852-0141 284 µM 0.538739887651875 0.307059867993712 no 1039 0.29503317338894 1406 2838987
SGTC_292 k038-0015 474 µM 0.537843050196582 0.307349329542241 no 1040 0.295342704072585 1441 46368540
SGTC_531 3788-1495 174 µM 0.536265347955792 0.30785883698218 no 1041 0.295887587880896 1414 2896655
SGTC_907 3448-6986 75.5 µM 0.535601640024258 0.308073287450744 no 1042 0.29611694752945 1518 590582
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.535546734823114 0.308091030790007 no 1043 0.296135924946465 1495 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3256 9138902 49.47 µM 0.534708898716096 0.308361844194465 no 1044 0.296425583567517 1485 17228773
SGTC_1082 camptothecin 424.86 nM 0.534439360103499 0.308448989230149 no 1045 0.296518796676837 1323 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2390 9097792 176.6 µM 0.534196064684352 0.308527658797971 no 1046 0.296602945772828 1383 4497149
SGTC_1506 4226-2149 212 µM 0.534145663407257 0.308543957148996 no 1047 0.296620379535764 1478 991114
SGTC_2827 7993847 71.43 µM 0.533602433546117 0.308719646299166 no 1048 0.296808312110891 1445 2985692
SGTC_960 1222-0186 7.7 µM 0.532800405963741 0.308979114779723 no 1049 0.297085876397515 1498 3126296
SGTC_1695 st026914 34.495 µM 0.532561470708249 0.309056432514782 no 1050 0.297168589629724 1397 3289191
SGTC_3148 9097893 49.47 µM 0.531781504368377 0.309308882894002 no 1051 0.297438667133086 1327 17174100
SGTC_1232 0279-0259 161 µM 0.531697140147781 0.30933619431631 no 1052 0.29746788649294 1437 1560000
SGTC_2829 7992743 58.44 µM 0.529566184848446 0.310026402366006 no 1053 0.298206372390508 1488 16462845
SGTC_906 1165-0455 526 µM 0.52620384098661 0.311116814333579 no 1054 0.299373292790958 1397 3252859
SGTC_1575 cyproterone acetate 48 µM 0.523549885880278 0.311978667934047 no 1055 0.300295822603546 1383 9880 An androgen receptor antagonist and liver toxin.
SGTC_886 0866-0150 153 µM 0.523484471524 0.31199992382458 no 1056 0.300318577221181 1551 271463
SGTC_2335 9018011 154.17 µM 0.52321856884144 0.312086333294317 no 1057 0.300411080440247 1549 6458208
SGTC_1271 0832-2808 169 µM 0.522914528688768 0.312185148836206 no 1058 0.300516866836426 1501 3663794
SGTC_3350 9150499 3.57 µM 0.522641919092015 0.312273760680139 no 1059 0.300611731724837 1403 4910996 YPR165W RHO1
SGTC_487 nimodipine 119 µM 0.521835568879981 0.312535928647283 no 1060 0.300892411084391 1433 4497 L-type voltage-gated calcium channels inhibitor
SGTC_3248 9135562 49.47 µM 0.519641355669269 0.313249811519107 no 1061 0.301656784063544 1466 17650701
SGTC_2024 5144227 134 µM 0.516244708599109 0.314356284584874 no 1062 0.302841754009241 1512 3475211
SGTC_194 1486-1323 56.904 µM 0.514300149090762 0.314990486024582 no 1063 0.303521078745353 1432 5178754
SGTC_768 0384-0033 77.3 µM 0.513692874028148 0.315188655529409 no 1064 0.303733367434136 1428 3965305 YMR134W ERG29
SGTC_3311 9131146 2.8755 µM 0.513002364489149 0.31541405121945 no 1065 0.303974833355421 1452 4900406 YPR165W RHO1
SGTC_7 0192-1582 4.227 µM 0.512647269059834 0.315529988002716 no 1066 0.304099040834398 1488 252616
SGTC_2168 5727979 200 µM 0.512558953829594 0.315558825279623 no 1067 0.304129935794505 1399 695210
SGTC_2796 7949634 45.45 µM 0.510455382858924 0.316246028944419 no 1068 0.304866232507991 1430 2971588
SGTC_475 α-linolenic acid 10 µM 0.508647141884582 0.316837260744144 no 1069 0.30549978948502 1540 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2852 9023854 51.95 µM 0.507315204817726 0.317273057250775 no 1070 0.305966835870193 1528 19798528
SGTC_390 dec-rvkr-cmk 16.7 µM 0.505837618475014 0.317756805319633 no 1071 0.306485323803304 1516 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_3033 9090887 49.47 µM 0.502287248384685 0.318920434816698 no 1072 0.307732738859975 1432 19325384
SGTC_855 0428-0020 25 µM 0.502145685678878 0.318966868944642 no 1073 0.307782522854923 1466 6812414
SGTC_3052 9092717 49.47 µM 0.501627672191881 0.31913680729525 no 1074 0.307964725156662 1477 25237534
SGTC_2433 5607874 27.82 µM 0.501383374115494 0.319216964371632 no 1075 0.308050669221373 1432 2252428
SGTC_546 peri-Naphthalide 147 µM 0.497168864461517 0.320601122570893 no 1076 0.309534987864314 1555 223824 A penicillin ester.
SGTC_890 0929-0006 47.2 µM 0.496380442902231 0.320860339384133 no 1077 0.309813010307006 1436 1378169
SGTC_1029 k015-0030 64.7 µM 0.496358341812612 0.32086760702764 no 1078 0.309820805420726 1533 2208316
SGTC_1400 3771-8998 51.5 µM 0.496348120312459 0.32087096825252 no 1079 0.309824410600227 1523 670767
SGTC_2627 acetyl isogambogic acid 100 µM 0.493500145896649 0.321808063590357 no 1080 0.310829618387005 1428 6857789 A caspase activator and apoptosis inducer.
SGTC_1024 4507-0395 26 µM 0.493324408272168 0.321865925388533 no 1081 0.310891692295089 1525 4201836
SGTC_579 4491-1009 110 µM 0.49096202214241 0.322644162366228 no 1082 0.311726654347502 1611 1271041
SGTC_2817 7995342 71.43 µM 0.486797331504853 0.324018021790857 no 1083 0.313200980800974 1416 18879975
SGTC_1629 st005085 44.9 µM 0.486136483763812 0.324236245177618 no 1084 0.313435200578257 1443 24207091
SGTC_2120 5538279 151.968 µM 0.484010789592423 0.324938595518059 no 1085 0.314189105908354 1537 2058197
SGTC_959 1222-0044 107 µM 0.483631336465036 0.32506403614439 no 1086 0.314323765645266 1557 6083612
SGTC_2555 cholic acid 100 µM 0.48347398445343 0.325116059809685 no 1087 0.314379613733022 1515 6708657 Influences liver metabolism.
SGTC_812 4251-0442 148 µM 0.481314435648897 0.325830393180839 no 1088 0.315146519414274 1512 5723007
SGTC_209 4077-0173 175.592 µM 0.480113867669392 0.326227792769899 no 1089 0.315573213962223 1494 15993494
SGTC_1982 st072467 71.9 µM 0.479195943035445 0.326531767867634 no 1090 0.315899620063255 1492 3163533
SGTC_372 0155-0182 15.9 µM 0.47899056216458 0.326599796498272 no 1091 0.315972671401319 1543 771486
SGTC_177 1327-0068 8.361 µM 0.478787665808617 0.32666700784134 no 1092 0.316044846086282 1483 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1810 st050138 53 µM 0.478015460554931 0.326922859593944 no 1093 0.316319600541076 1539 3444541
SGTC_2212 7123476 200 µM 0.477830186282288 0.326984257905669 no 1094 0.316385537138494 1530 1085715
SGTC_2767 sibutramine 71.45 µM 0.47654003492425 0.327411932834488 no 1095 0.31684484624618 1624 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2253 7938677 135.83 µM 0.475182408737159 0.327862219847982 no 1096 0.317328482198541 1622 2301972
SGTC_2980 9014342 25.29 µM 0.474454029208275 0.328103906413305 no 1097 0.317588086232119 1518 2996599
SGTC_159 3970-0959 50 µM 0.472599044083837 0.328719741470192 no 1098 0.318249632298862 1580 6615653
SGTC_1108 betulinic acid 729.144 nM 0.471934548817724 0.328940460043834 no 1099 0.318486753460996 1507 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_555 4296-0685 37 µM 0.470872868106095 0.329293231421287 no 1100 0.318865762180151 1555 2908540 YHR072W ERG7
SGTC_2922 7999257 32.47 µM 0.470142635531447 0.329535958691641 no 1101 0.319126557466493 1489 2988377
SGTC_566 0958-0068 16.5 µM 0.468718363502886 0.330009589360699 no 1102 0.319635479591598 1547 6815365
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.465718732414966 0.331007984470622 no 1103 0.320708421044643 1611 5282309
SGTC_1977 st070720 65.3 µM 0.465182957101885 0.331186438369959 no 1104 0.320900221223344 1521 682188
SGTC_3115 9123671 49.47 µM 0.464694684784483 0.331349103562203 no 1105 0.321075057623964 1600 3286988
SGTC_1136 pergolide 1.05886 µM 0.463154655591181 0.331862364031144 no 1106 0.321626757939028 1543 47811 A dopamine receptor agonist.
SGTC_2423 st077119 87.2 µM 0.462701164055048 0.332013563771468 no 1107 0.321789291895227 1481 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3201 9113999 49.47 µM 0.461746117229035 0.332332077759615 no 1108 0.322131697653557 1611 16649224
SGTC_1134 3477-0009 42.5 µM 0.459331982281385 0.333137746279181 no 1109 0.322997892145146 1717 3973534
SGTC_1811 st050069 61.5 µM 0.458165092314422 0.333527448644923 no 1110 0.323416918430925 1548 3877702
SGTC_2898 9056270 58.44 µM 0.458015127778171 0.333577544843554 no 1111 0.32347078645372 1529 19154699
SGTC_424 splitomicin 100 mM 0.455887567846487 0.334288583312169 no 1112 0.324235414942659 1507 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1251 0490-5699 265 µM 0.45544102716594 0.334437894505422 no 1113 0.324395992490534 1656 3883818
SGTC_1096 rimcazole 32.2 µM 0.454149320177226 0.334869953984722 no 1114 0.324860678512692 1535 18528119 A dopamine reuptake inhibitor.
SGTC_699 0375-0592 111 µM 0.453909783190198 0.334950100097386 no 1115 0.324946880901293 1593 762578
SGTC_1442 4112-3290 3 µM 0.453423238816029 0.33511291496413 no 1116 0.325122002908644 1534 704353
SGTC_927 2425-1185 123 µM 0.452588689442087 0.33539225669305 no 1117 0.325422472377963 1483 730375
SGTC_749 1000-0129 128 µM 0.451211933032402 0.335853285745522 no 1118 0.325918404983765 1679 708470
SGTC_2979 9012552 45.46 µM 0.449515395420222 0.336421738535577 no 1119 0.326529952349622 1592 17100905
SGTC_2832 7992762 51.95 µM 0.447769441017986 0.337007139880235 no 1120 0.327159800006795 1398 2985177
SGTC_276 colchicine 750 µM 0.446023283461905 0.33759300443807 no 1121 0.327790213634881 1593 2833 A microtubule depolymerizer.
SGTC_2742 clothiapine 36.27 µM 0.445361575762297 0.337815121225257 no 1122 0.328029237762286 1631 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_361 000s-0510 1.45 µM 0.444707874449391 0.338034605966058 no 1123 0.328265438975061 1566 660
SGTC_2773 thioridazine 9.09 µM 0.444693988151604 0.338039268984241 no 1124 0.32827045724174 1564 5452 An antipsychotic.
SGTC_2394 5221648 200 µM 0.443443308450072 0.338459349004581 no 1125 0.328722558137671 1707 788586
SGTC_3127 9126946 49.47 µM 0.44289482070949 0.338643639290512 no 1126 0.328920906913561 1500 27243249
SGTC_2908 7930301 100 µM 0.441576964301394 0.339086593101974 no 1127 0.329397678193345 1476 2223178
SGTC_505 gw-5074 63.9 µM 0.438432284889292 0.340144471101202 no 1128 0.330536473606826 1645 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3244 9134489 49.47 µM 0.437653356631391 0.340406699473986 no 1129 0.330818793171234 1511 16584271
SGTC_753 1322-0200 289 µM 0.436791859277041 0.340696814851158 no 1130 0.331131151688626 1572 5403907
SGTC_2191 5911152 200 µM 0.436306425152253 0.340860329787168 no 1131 0.331307210390938 1583 2875902
SGTC_2863 9028737 58.44 µM 0.435812730721665 0.341026657817201 no 1132 0.331486303215617 1671 6460917
SGTC_1395 3486-0190 4.35 µM 0.435760977394302 0.341044095552225 no 1133 0.331505079509352 1691 6748079
SGTC_1078 idebenone 36.1 µM 0.434874602256367 0.341342802937473 no 1134 0.331826725302383 1580 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1150 3909-7983 10.9 µM 0.434708512038439 0.341398786213227 no 1135 0.331887009544149 1542 23965914
SGTC_1830 st055982 50.3 µM 0.434533370820648 0.341457824049033 no 1136 0.331950583659216 1676 455313 An antimicrobial agent.
SGTC_1463 k081-0032 34.1 µM 0.431544185996232 0.342466036643105 no 1137 0.333036365793908 1487 977755
SGTC_3221 9128209 49.47 µM 0.430096173722004 0.342954836504828 no 1138 0.333562841628098 1596 16460723
SGTC_3309 9129340 25.759 µM 0.429939498800108 0.343007740427331 no 1139 0.333619825990923 1640 17158987
SGTC_1294 1000-1494 117 µM 0.428768885831866 0.343403114931058 no 1140 0.334045711990606 1537 712797 YDL207W GLE1
SGTC_2698 st077697 67.5 µM 0.426236619545532 0.34425897384905 no 1141 0.334967718139648 1530 3154499
SGTC_1203 3992-3522 103 µM 0.42396193778622 0.345028454767443 no 1142 0.335796786014522 1813 5322312
SGTC_1151 3909-8316 15.3 µM 0.422851403437009 0.34540436027094 no 1143 0.336201840420738 1583 800431
SGTC_681 1642-0006 26.6 µM 0.422489941043599 0.345526744836464 no 1144 0.336333720658442 1557 4446530
SGTC_2720 fluspirilene 36.88 µM 0.419802556709295 0.346437149696313 no 1145 0.33731484850218 1650 3396 An atypical antipsychotic.
SGTC_731 3966-0296 387 µM 0.419661344147301 0.346485012855637 no 1146 0.337366433985303 1604 660956
SGTC_914 3820-6779 408 µM 0.419016113429692 0.346703741152904 no 1147 0.337602178091817 1541 2893481
SGTC_1581 himbacine 57.9 µM 0.418293501628 0.346948761716851 no 1148 0.337866270131028 1579 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2740 felodipine 17.08 µM 0.416669064604537 0.347499803433159 no 1149 0.338460242411718 1706 3333 L-type calcium channel blocker
SGTC_2992 9074591 71.4286 µM 0.416661194405587 0.347502473948713 no 1150 0.338463121114856 1603 17741321
SGTC_691 1548-0686 185 µM 0.415203046556966 0.347997383092917 no 1151 0.338996634383637 1555 46495133
SGTC_1612 st002233 45.4 µM 0.414978021282317 0.34807378188842 no 1152 0.339078996379646 1607 1035021
SGTC_585 0kpi-0023 191 µM 0.414754041346143 0.348149831902876 no 1153 0.33916098340688 1690 64601
SGTC_2321 7390090 138.78 µM 0.414373952071877 0.348278901162766 no 1154 0.339300131107802 1524 649046
SGTC_2910 7948405 25.97 µM 0.409866405978893 0.349810892661958 no 1155 0.340951974951302 1712 2971328
SGTC_2012 4023501 200 µM 0.409767841299104 0.349844419542477 no 1156 0.340988129378528 1559 3477460
SGTC_2356 9061756 188.97 µM 0.409570803459578 0.349911445682438 no 1157 0.341060409039679 1703 20104043
SGTC_1839 st053978 48 µM 0.406695919195141 0.350889922824369 no 1158 0.342115669034402 1637 3788398
SGTC_2268 7933382 153.85 µM 0.406490437837828 0.350959897111974 no 1159 0.3421911407358 1591 935025 YOR257W CDC31
SGTC_497 capsazepine 133 µM 0.404705242116307 0.351568037254653 no 1160 0.342847094226474 1532 2733484 A calcium channel blocker.
SGTC_2650 prasterone 100 µM 0.404355192836993 0.351687328754607 no 1161 0.342975772213206 1623 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_3270 9137563 49.47 µM 0.404139103094804 0.351760976161904 no 1162 0.343055215816814 1682 17015724
SGTC_1148 3909-7663 27.7 µM 0.404086723101868 0.351778829076496 no 1163 0.343074473932148 1695 4084526
SGTC_1530 rhein 70.4 µM 0.403578183272611 0.351952174037178 no 1164 0.343261465714646 1624 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2751 anetholtrithion 17.25 µM 0.401853619183652 0.352540251722512 no 1165 0.343895879189177 1726 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3316 9136639 10.545 µM 0.401370583448415 0.352705030557401 no 1166 0.344073651922529 1691 4903665
SGTC_1031 k035-0009 16 µM 0.40112889506442 0.352787488519479 no 1167 0.344162613985053 1750 5180959
SGTC_1081 sertraline 6 µM 0.399842021430417 0.35322665360994 no 1168 0.344636439017658 1719 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_383 2324-0395 7.37 µM 0.396339743701011 0.354422847595642 no 1169 0.345927205737109 1696 3146421
SGTC_423 5-fluorouracil 457 µM 0.396310591638738 0.35443281045603 no 1170 0.345937957291136 1530 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2713 st079149 53.4 µM 0.395464979267892 0.354721845958994 no 1171 0.346249881094018 1652 3103253
SGTC_905 2-aminofluorene 215 µM 0.395435068190809 0.3547320712817 no 1172 0.346260916402442 1615 1539 An established DNA mutagen. YPR165W RHO1
SGTC_51 1013-0126 23.419 µM 0.394565085795558 0.355029526958879 no 1173 0.346581942328328 1766 1627850
SGTC_3021 9087658 49.47 µM 0.394556972983345 0.355032301226655 no 1174 0.346584936497627 1664 25237042
SGTC_3102 9121669 49.47 µM 0.394224509334766 0.355145997536057 no 1175 0.346707646020666 1672 41905072
SGTC_1063 disulfiram 1.84 µM 0.393535470520928 0.355381676894723 no 1176 0.346962015621273 1639 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2359 9039622 200 µM 0.388486793307128 0.35711021264069 no 1177 0.348827912776108 1710 6463596
SGTC_858 0438-0351 2.77 µM 0.387308054875829 0.357514206216725 no 1178 0.349264081535517 1608 2799119
SGTC_954 1189-0853 2.85 µM 0.386818848126992 0.357681920861152 no 1179 0.349445161296018 1626 2828194
SGTC_1704 st028805 70.8 µM 0.38622433932512 0.357885773176642 no 1180 0.349665264711128 1637 2876101
SGTC_3105 9121040 49.47 µM 0.385947543754984 0.357980697997963 no 1181 0.349767759248858 1627 41448907
SGTC_1615 st002656 86.5 µM 0.384822749171465 0.358366527573914 no 1182 0.350184371640003 1628 1584458
SGTC_613 3914-0030 117 µM 0.383156714324297 0.358938280311446 no 1183 0.350801785184833 1630 1145395
SGTC_1338 1486-1223 76 µM 0.383078559980486 0.358965109228593 no 1184 0.35083075798727 1715 3444526
SGTC_1786 berberine 21.6 µM 0.382016724038019 0.359329686433722 no 1185 0.351224479873512 1584 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1156 4092-0367 4.88 µM 0.378084156839113 0.36068103147682 no 1186 0.352684038662526 1684 1357585
SGTC_1235 benzylparaben 21.5 µM 0.376029205640858 0.36138786669408 no 1187 0.353447591880031 1671 7180
SGTC_1217 1183-1422 255 µM 0.375909267099191 0.361429136228048 no 1188 0.353492175409292 1749 2849664
SGTC_1196 1588-0294 184 µM 0.375310091125154 0.361635330234002 no 1189 0.353714931068716 1622 6144269
SGTC_1088 bifonazole 369 nM 0.374697269178204 0.361846261787137 no 1190 0.35394281171377 1648 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2027 5150920 200 µM 0.373147061461242 0.362380026098559 no 1191 0.354519497007566 1726 786715
SGTC_763 3453-1109 128 µM 0.372683108498857 0.36253982550748 no 1192 0.35469215484223 1788 1560353
SGTC_541 4513-1321 94 µM 0.371707910376755 0.362875791233505 no 1193 0.355055167366775 1628 747515
SGTC_1292 0kpi-0043 232 µM 0.371364787284574 0.362994025768885 no 1194 0.355182924502623 1650 3333905
SGTC_1440 4100-1550 40 µM 0.371158555403662 0.3630650961443 no 1195 0.355259719924101 1667 742806
SGTC_2977 9011197 71.43 µM 0.370482769194214 0.363298014506525 no 1196 0.355511406416796 1729 2704722
SGTC_279 1273-0055 2.93 µM 0.369773528304096 0.363542517824345 no 1197 0.355775620383461 1785 2847562
SGTC_889 0919-1524 82.7 µM 0.369603821612172 0.36360103066322 no 1198 0.355838851606392 1643 3905452
SGTC_2296 7971656 126.45 µM 0.368666266666292 0.363924345713546 no 1199 0.356188247784717 1639 666570
SGTC_2192 5915882 198.485 µM 0.367299864831065 0.364395721727632 no 1200 0.356697677450386 1674 2876149
SGTC_1958 st076513 41.9 µM 0.365720703891387 0.364940750089811 no 1201 0.35728674768284 1639 732122 YGL099W LSG1
SGTC_798 1287-0182 476 µM 0.364712135140648 0.365288988373249 no 1202 0.357663149576952 1815 1649755
SGTC_199 4063-0024 41.6 µM 0.363304914699801 0.365775058582596 no 1203 0.358188561206325 1766 306215
SGTC_2215 7188065 200 µM 0.362598885760648 0.366019010399694 no 1204 0.358452271369892 1757 940217
SGTC_2134 5324836 1.464 µM 0.362200854171431 0.366156564809304 no 1205 0.358600970648215 1713 699272
SGTC_2176 5809774 33.9695 µM 0.361846380083992 0.366279080809278 no 1206 0.358733415475358 1815 2870539
SGTC_2280 7785178 200 µM 0.360798362561972 0.366641384194283 no 1207 0.359125093479103 1696 2954328
SGTC_884 0851-0618 334 µM 0.360125569036687 0.36687403397335 no 1208 0.359376616248812 1793 9642473
SGTC_1762 st045503 25.4615 µM 0.35999623877079 0.366918761558887 no 1209 0.359424973146452 1675 4645554
SGTC_2379 9035213 200 µM 0.358598116853775 0.367402403329178 no 1210 0.359947877879154 1840 646551
SGTC_2652 actinonin 100 µM 0.354510571489414 0.368817581401983 no 1211 0.361478141456641 1711 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1926 methyl fluorone black 53.6 µM 0.35423420257792 0.368913329520091 no 1212 0.361581686651089 1684 72721 Reacts with homocysteine.
SGTC_1123 mangostin 811.285 nM 0.352505120483125 0.36951255516064 no 1213 0.362229739509453 1662 5281650 An antioxidant.
SGTC_701 4424-0219 185 µM 0.352175280128715 0.369626899729373 no 1214 0.362353407245024 1816 2911779
SGTC_629 3448-6466 76.7 µM 0.351748059233359 0.369775019998208 no 1215 0.362513607423781 1707 573744
SGTC_2127 5253358 187.912 µM 0.349791960640602 0.370453458616277 no 1216 0.363247416427374 1646 20612
SGTC_2125 5246583 200 µM 0.348593875689873 0.370869192659879 no 1217 0.363697113081652 1873 835267
SGTC_3321 9137793 26.8275 µM 0.348169459223141 0.371016500859715 no 1218 0.363856461286146 1700 4904192
SGTC_100 0086-0128 49.5915 µM 0.347242857048518 0.371338175384388 no 1219 0.364204438141168 1616 93297
SGTC_314 1671-0008 2.74 µM 0.345583884838193 0.37191432020126 no 1220 0.364827729321208 1715 3913060
SGTC_3184 9108758 49.47 µM 0.345264181152352 0.372025383179319 no 1221 0.364947886074385 1702 902885
SGTC_909 3448-9333 149 µM 0.345238837572278 0.372034187829599 no 1222 0.364957411719152 1647 3344074
SGTC_1331 1472-0049 76.2 µM 0.344855693459121 0.372167304637105 no 1223 0.365101430519159 1664 24051409
SGTC_3004 9076122 71.4286 µM 0.344731589869641 0.372210425563316 no 1224 0.365148083496791 1798 44782551
SGTC_2640 pentamidine 10.38 µM 0.344318201907429 0.372354072544338 no 1225 0.365303498547774 1853 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1821 st053465 65.6 µM 0.340104812737164 0.373819180736002 no 1226 0.36688879877667 1699 675086
SGTC_1248 0469-0687 58.6 µM 0.338225712654956 0.374473183914149 no 1227 0.367596550288734 1777 4017482
SGTC_2105 5350118 200 µM 0.337882337260878 0.374592731602114 no 1228 0.367725929212557 1689 2133313
SGTC_2667 digitoxin 100 µM 0.336613365391285 0.375034634379244 no 1229 0.368204189754492 1829 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1638 st008370 60.6 µM 0.336394685623442 0.375110803325999 no 1230 0.368286628241057 1685 24207134
SGTC_1883 5-benzylidenerhodanine 20 µM 0.335444914197455 0.375441677282784 no 1231 0.368644745950213 1833 1273210
SGTC_2588 indole-3-carbinol 100 µM 0.334739423939553 0.375687509807962 no 1232 0.368910829679209 1870 3712 Induces cell cycle arrest.
SGTC_3340 9146634 11.102 µM 0.334676507443922 0.375709435910064 no 1233 0.368934562409884 1702 4907387
SGTC_2727 riluzole 51.77 µM 0.332765578599397 0.376375576523551 no 1234 0.369655621560188 1783 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_876 0720-0963 56.8 µM 0.332221453474211 0.376565323396117 no 1235 0.369861022673288 1871 765861
SGTC_2703 st077852 53.4 µM 0.331836720290745 0.376699505244009 no 1236 0.370006277535232 1740 6281836
SGTC_945 3381-0768 11.3 µM 0.331329995222333 0.37687625644122 no 1237 0.370197618363848 1813 1126236 YIL048W NEO1
SGTC_686 1319-0111 510 µM 0.331029694783336 0.37698101667139 no 1238 0.370311027829076 1824 4562600
SGTC_1715 st032160 10.2275 µM 0.330930202156011 0.37701572681199 no 1239 0.370348604039455 1818 5289825
SGTC_1425 4048-4433 7.33 µM 0.330605261131144 0.377129096392013 no 1240 0.370471335843604 1820 23734946
SGTC_1654 st012436 41.8 µM 0.329512195475018 0.377510536808221 no 1241 0.370884288765704 1819 4323132
SGTC_3118 9124250 49.47 µM 0.329397005167033 0.37755074103022 no 1242 0.370927815568828 1718 1504786
SGTC_2085 5307070 144.047 µM 0.328425749863741 0.377889785497046 no 1243 0.371294888094643 1695 2840351
SGTC_3264 9137442 49.47 µM 0.326936374573751 0.378409877253536 no 1244 0.371858004286998 1827 17015726
SGTC_2733 amorolfine 100 µM 0.325459300685866 0.378925890988468 no 1245 0.372416740336262 1843 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_181 1447-1644 8.07 µM 0.323116743105154 0.379744702598136 no 1246 0.37330341532274 1866 534600
SGTC_125 0133-0007 11.75 µM 0.321624154184455 0.380266699957813 no 1247 0.373868721478158 1916 26541
SGTC_1812 st052057 4.327 µM 0.320455010196849 0.380675732580985 no 1248 0.374311715083274 1701 3645418
SGTC_999 SEC7.066 22.7 µM 0.319547734693641 0.380993240777949 no 1249 0.374655600033005 1789 740511 YDR170C SEC7
SGTC_1077 5-fluorocytosine 377 nM 0.316251753660865 0.382147368232376 no 1250 0.375905714091106 1762 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2341 7987486 176.74 µM 0.314033384040474 0.38292474778603 no 1251 0.376747841788697 1903 1258686
SGTC_1688 st021091 57.6 µM 0.313502165419923 0.383110971974807 no 1252 0.376949587893368 1892 3656366
SGTC_580 1123-0028 41 µM 0.312717153600156 0.383386215448694 no 1253 0.37724778103084 1792 1677248 YPR107C YTH1
SGTC_821 1114-0266 29.2 µM 0.312108536032261 0.383599651499271 no 1254 0.377479019766186 1741 3123235
SGTC_870 0573-2213 57.6 µM 0.312049589257284 0.383620325416817 no 1255 0.377501418394337 1710 3916321
SGTC_2532 xanthone 78.9 µM 0.310664837834338 0.384106083083812 no 1256 0.378027715378418 1827 7020 An insecticide.
SGTC_1269 0831-0796 3.05 µM 0.310404718149361 0.384197350942364 no 1257 0.378126603328521 1850 927758
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.308304900941749 0.384934345835862 no 1258 0.378925168576493 1933 688664
SGTC_788 1182-0090 188 µM 0.308262509706721 0.384949228624559 no 1259 0.378941295395534 1902 5715185
SGTC_3128 9127691 49.47 µM 0.307556905212427 0.385196978356664 no 1260 0.379209758134141 1783 41316314
SGTC_3291 9121177 71.43 µM 0.305724838983517 0.385840466538383 no 1261 0.379907079743369 1739 17015612
SGTC_316 k060-0003 58.6 µM 0.305620722065572 0.385877045634325 no 1262 0.379946720508874 1853 6152314
SGTC_931 2812-0076 566 µM 0.305261076929847 0.386003406525263 no 1263 0.38008365904744 1739 3450959
SGTC_1806 st050005 60.3 µM 0.304535580745038 0.386258345543504 no 1264 0.380359944827506 1725 5194765
SGTC_1792 st045773 43.6 µM 0.303313902836592 0.386687753521515 no 1265 0.380825326008395 1766 2919270
SGTC_1711 st032263 62.8 µM 0.302578620567441 0.386946265061577 no 1266 0.381105504730491 1822 3958979
SGTC_1224 0823-0416 294 µM 0.302228898452074 0.387069238448179 no 1267 0.381238787949229 1842 3598164
SGTC_1609 st001574 46.4 µM 0.300550572932689 0.387659548461023 no 1268 0.381878613354195 1736 3960012
SGTC_1611 st001856 99.4 µM 0.299134827472226 0.388157704405265 no 1269 0.382418586855606 1744 647478
SGTC_2999 9069765 71.4286 µM 0.298940564029971 0.388226073931995 no 1270 0.382492697923191 1836 2097066
SGTC_2592 piperlongumine 83.33 µM 0.29848940378939 0.388384869674959 no 1271 0.382664831143774 1709 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_485 niflumic acid 177 µM 0.295992424303443 0.38926407309266 no 1272 0.383617933425776 1836 4488 A COX2 inhibitor.
SGTC_835 0312-0010 67.2 µM 0.295519386039802 0.389430697117856 no 1273 0.383798572678114 1777 1626196
SGTC_714 4296-0578 26.1 µM 0.295518232074591 0.389431103617938 no 1274 0.383799013374021 1918 1589775
SGTC_1285 0929-0069 65.5 µM 0.293996584966947 0.389967229795491 no 1275 0.38438025646152 1796 1206237
SGTC_680 0417-1641 114 µM 0.291302546199455 0.390916940956415 no 1276 0.385409970132608 1767 2835990
SGTC_1086 cerivastatin 2.18 µM 0.290262563849851 0.391283733318145 no 1277 0.3858076881276 1865 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2945 9067681 61.76 µM 0.289107126734646 0.391691358922921 no 1278 0.38624970001095 1837 16456930
SGTC_744 1594-0068 283 µM 0.288890573611616 0.391767769749728 no 1279 0.386332558747342 1775 668392
SGTC_1913 st060213 96.1 µM 0.288216426620946 0.392005669412599 no 1280 0.386590537715389 1920 688959
SGTC_2602 kawain 100 µM 0.287986018484844 0.392086987379448 no 1281 0.386678720569713 1865 5369129
SGTC_141 0443-0274 32.331 µM 0.285704311738637 0.392892524291294 no 1282 0.387552301004053 1949 1627241
SGTC_1471 k673-0312 37 µM 0.285041078428901 0.393126759337364 no 1283 0.387806335353202 1918 24099884
SGTC_948 3448-0295 75.3 µM 0.283650512343112 0.393617993058273 no 1284 0.388339111488036 1774 678569
SGTC_892 0929-0076 29 µM 0.283128278250911 0.393802522142817 no 1285 0.388539252588779 1787 5751038
SGTC_3013 9080133 71.4286 µM 0.282780080638099 0.393925569468607 no 1286 0.388672712360877 1848 17050193
SGTC_3337 9144342 33.5465 µM 0.281091339669521 0.394522492853929 no 1287 0.389320171720376 1884 17682949
SGTC_2276 7947513 42.08 µM 0.280651436068729 0.394678027383935 no 1288 0.389488880276273 1662 2105100
SGTC_561 1550-0330 72.9 µM 0.280540591044078 0.394717220957649 no 1289 0.389531394022164 1776 6812934
SGTC_1726 st035556 14.5795 µM 0.280179518075072 0.394844899749865 no 1290 0.389669889912124 1908 5919439
SGTC_3186 9110464 49.47 µM 0.280067254276928 0.394884599585321 no 1291 0.389712953523332 1895 17018021
SGTC_1093 fluphenazine 7.97 µM 0.277439028387317 0.395814329869788 no 1292 0.390721508506142 1842 6602611 An atypical antipsychotic.
SGTC_3082 9117008 49.47 µM 0.273874162160634 0.397076341962458 no 1293 0.392090664144339 1813 41448529
SGTC_2610 ononetin 44.17 µM 0.273397554192938 0.397245149816275 no 1294 0.392273816334768 1776 259632
SGTC_848 0368-0089 85.6 µM 0.273051438602807 0.39736775116889 no 1295 0.392406837525488 1915 762535
SGTC_1431 4049-0260 9.09 µM 0.272045223032048 0.397724231237375 no 1296 0.392793623593435 1889 3854841
SGTC_3355 9151058 44.0485 µM 0.270466690049656 0.398283642798428 no 1297 0.393400619881715 1897 17015728
SGTC_3297 9117502 71.43 µM 0.270029365308362 0.398438662041356 no 1298 0.393568831109077 1886 7453720
SGTC_517 1365-0151 113 µM 0.268377362662215 0.399024394658396 no 1299 0.394204431272385 1850 768657
SGTC_3273 9137859 49.47 µM 0.266264966985855 0.399773695029898 no 1300 0.395017575882226 1959 2377234
SGTC_1418 3966-3099 2.4 µM 0.265916209640489 0.399897440398013 no 1301 0.395151870463714 1908 740335
SGTC_1857 st056007 79.3 µM 0.265860840004019 0.399917087464277 no 1302 0.395173192571917 1954 619834
SGTC_520 3584-0023 682 µM 0.263549590658283 0.400737424284463 no 1303 0.396063503121452 1783 1340790
SGTC_560 2332-1943 155 µM 0.258982345233615 0.402359771371006 no 1304 0.397824431178879 1857 21177716
SGTC_418 lividomycin a 100 µM 0.257142986498543 0.403013613411223 no 1305 0.398534197252354 1946 72394 An antibiotic.
SGTC_70 0141-0289 43.283 µM 0.25709403025016 0.403031019741373 no 1306 0.398553092935899 1900 352408
SGTC_2851 9015922 71.43 µM 0.256691470684135 0.403174156552657 no 1307 0.398708478197835 1931 2996893
SGTC_1061 3448-9325 110 µM 0.255571429518123 0.403572474202472 no 1308 0.399140890906822 1975 723482
SGTC_808 0711-0032 135 µM 0.255308185158435 0.403666105719752 no 1309 0.399242539270427 1982 4252555
SGTC_131 0141-0277 33.849 µM 0.254563922620412 0.403930857032194 no 1310 0.399529963448123 1942 1547771
SGTC_2478 5763493 32.33 µM 0.254363721299652 0.404002080766609 no 1311 0.399607287805739 1899 1365576 YLR208W SEC13
SGTC_2995 9067767 71.4286 µM 0.254026798455754 0.404121951810871 no 1312 0.399737427416297 1868 11673567
SGTC_3260 9137109 49.47 µM 0.253792338741944 0.404205373642811 no 1313 0.399827996254723 1961 17478346
SGTC_3351 9150312 21.596 µM 0.249677186106928 0.405670269600588 no 1314 0.401418501191934 1949 4904905
SGTC_2305 7443522 69.23 µM 0.249023019984455 0.40590325941399 no 1315 0.401671487417344 1903 5415886
SGTC_3179 9107801 49.47 µM 0.246285449258277 0.406878641723776 no 1316 0.402730636458739 1830 4818259
SGTC_1664 st014217 9.02 µM 0.245170469210161 0.407276069318082 no 1317 0.403162220429168 1987 3982782
SGTC_1897 st060201 15 µM 0.239992614538154 0.409122927863334 no 1318 0.405167991032463 1820 611878
SGTC_129 0088-0017 176.636 µM 0.239375830561106 0.409343060301007 no 1319 0.405407084853837 2000 182446
SGTC_1142 3253-1408 9.78 µM 0.239150776286181 0.409423390110352 no 1320 0.405494335031351 2008 256655
SGTC_2070 5230947 200 µM 0.23724543853877 0.410103624432328 no 1321 0.406233193748836 2001 2835538
SGTC_2886 9058944 51.95 µM 0.236429855197224 0.410394882816648 no 1322 0.406549565838196 1909 4949929
SGTC_2704 st078022 71.1 µM 0.235289892693886 0.41080206519206 no 1323 0.406991869703808 2005 54697681
SGTC_1416 3966-0321 25.3 µM 0.233827756152455 0.411324465360778 no 1324 0.407559350262582 1908 582530 YLR208W SEC13
SGTC_1630 st005209 31.3 µM 0.232570736097279 0.411773706144909 no 1325 0.408047376721559 2051 3367314
SGTC_1647 st011722 22.4 µM 0.231050439438498 0.412317192676519 no 1326 0.408637808481876 1952 2854783
SGTC_1097 itavastatin 7.23 µM 0.229043977476758 0.413034734368609 no 1327 0.409417367720186 1914 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3002 9075603 71.4286 µM 0.228918505457269 0.413079614774758 no 1328 0.409466128585124 2000 20105405
SGTC_1574 spiramycin 23.7 µM 0.228212572799698 0.413332142783764 no 1329 0.40974049381961 1905 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2606 farnesol 9.78 µM 0.226313973029895 0.414011492303873 no 1330 0.410478615697348 2000 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_299 1273-0059 1.44 µM 0.226137145050205 0.414074777331507 no 1331 0.410547377600452 2006 2848077
SGTC_2869 9037858 32.47 µM 0.225930594735712 0.414148702521194 no 1332 0.410627700908936 2014 27187042
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.225166338361375 0.414422259386844 no 1333 0.410924937578799 1985 16725076
SGTC_2033 5192550 145 µM 0.224268494528083 0.414743685388744 no 1334 0.411274194782607 1873 182073
SGTC_1194 1488-0194 225 µM 0.223645093199277 0.414966895206909 no 1335 0.411516736476101 1911 1391452
SGTC_3292 9120825 59.784 µM 0.223318999390216 0.415083664544458 no 1336 0.411643620623879 2059 24824900
SGTC_397 arbidol 50 µM 0.223089674080256 0.415165787016806 no 1337 0.411732857372942 1998 131410 A RNA synthesis inhibitor.
SGTC_249 wiskostatin 11.211 µM 0.222964585442844 0.415210583408889 no 1338 0.41178153470696 2002 2775510 A n-wasp and actin depolymerizer.
SGTC_2062 5245942 200 µM 0.221720775015781 0.415656073191704 no 1339 0.412265628242678 2003 1376160
SGTC_2440 5628896 157.78 µM 0.220437424853233 0.416115838384556 no 1340 0.412765250670856 1896 5522048
SGTC_1862 st057513 3.81 µM 0.22040648016703 0.416126925859026 no 1341 0.412777299528364 1906 5393163
SGTC_450 aminopyrene 156 nM 0.220247453411214 0.416183906164492 no 1342 0.412839220687146 2006 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1689 st020265 53.493 µM 0.219853928171536 0.416324916350356 no 1343 0.412992459184614 2031 5758320 YPR016C TIF6
SGTC_1694 st024011 44.9 µM 0.218245901954272 0.416901225117075 no 1344 0.413618761186224 2002 2787533
SGTC_3279 9140807 49.47 µM 0.21823871818504 0.41690380014668 no 1345 0.413621559650578 2014 45595718
SGTC_1627 st003713 25.6 µM 0.218135444722163 0.41694081902157 no 1346 0.413661790701743 1884 16195070 YER133W GLC7
SGTC_851 0394-0702 453 µM 0.218048801008333 0.416971877450196 no 1347 0.413695544192653 2045 762646
SGTC_718 1130-0073 349 µM 0.217868295581132 0.417036583345871 no 1348 0.413765865113334 1971 6740020
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.217786370717525 0.417065951745564 no 1349 0.413797782140129 1993 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_414 piperonyl butoxide 100 µM 0.215542342633312 0.417870569635905 no 1350 0.414672251561542 1881 5794 A potent inhibitor of cytochrome P450.
SGTC_2630 antimycin a 100 µM 0.21425105485809 0.418333729419227 no 1351 0.415175642146558 1913 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_3111 9122088 49.47 µM 0.214223762585187 0.41834351985057 no 1352 0.415186283165573 2026 16876704
SGTC_1569 carminic acid 40.6 µM 0.213955225153093 0.418439853743489 no 1353 0.415290986883169 2035 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_756 0508-1999 28.3 µM 0.213117378924679 0.418740450294104 no 1354 0.415617704796444 1822 6753853
SGTC_1774 st048371 48.465 µM 0.211388616909521 0.41936083309388 no 1355 0.416292019225089 1856 4242727
SGTC_1352 1496-0991 99 µM 0.211263920148068 0.419405589492166 no 1356 0.41634066752934 1892 3000039
SGTC_2046 4110841 106 µM 0.210085644308827 0.419828549892063 no 1357 0.416800414822269 2066 44119630 YMR134W ERG29
SGTC_2914 7968218 45.32 µM 0.209477847009799 0.420046764409545 no 1358 0.417037613643667 2008 2977111
SGTC_2340 7987427 183.45 µM 0.208487631122894 0.420402329436331 no 1359 0.417424119693992 1961 2239331
SGTC_2735 sertaconazole 140 nM 0.20782501916808 0.420640295301072 no 1360 0.417682798317003 2044 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_838 0109-0203 71.4 µM 0.206449361580171 0.421134431951837 no 1361 0.418219958114669 1943 759422
SGTC_2016 5121758 140 µM 0.205532261212569 0.421463923779742 no 1362 0.418578147639198 2022 2795203
SGTC_2575 plumbagin 510 nM 0.204814021419263 0.421722008262271 no 1363 0.418858715864964 1863 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3312 9133330 71.43 µM 0.204364988429322 0.42188337598738 no 1364 0.419034143984775 2026 17617324
SGTC_692 k241-0027 77.8 µM 0.20305959194735 0.422352567055526 no 1365 0.419544227333567 2030 3600480
SGTC_747 3448-8087 38.7 µM 0.201763324164506 0.422818586103841 no 1366 0.420050877459578 1906 5168703
SGTC_2475 5812728 15.03 µM 0.200327650630328 0.423334848741035 no 1367 0.420612169375968 2045 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1264 0783-0040 158 µM 0.199792743486739 0.42352723298756 no 1368 0.420821338385363 1881 2855798
SGTC_500 h-89 112 µM 0.199280835343826 0.42371136250661 no 1369 0.421021534846827 2066 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_3080 9117754 49.47 µM 0.19739832011472 0.424388632084938 no 1370 0.421757922056413 2060 9550191
SGTC_339 3091-4833 71.4 µM 0.197367445330442 0.42439974172489 no 1371 0.421770001694997 1994 3240077
SGTC_2853 9015042 58.44 µM 0.197046583113486 0.424515200780536 no 1372 0.421895542137762 1954 6457456
SGTC_2302 7771753 200 µM 0.196595736077084 0.424677444514698 no 1373 0.422071953806517 1878 2203047
SGTC_919 tnp00227 403.569 nM 0.196191669382353 0.424822864521002 no 1374 0.422230074111514 1931 1269246 A methoxyflavone. YNL221C POP1
SGTC_1008 4106-0037 6 µM 0.19523974562282 0.425165493818316 no 1375 0.422602632606296 1961 2905394
SGTC_1742 st038235 28.8875 µM 0.194888544714931 0.425291917097188 no 1376 0.422740101119822 1945 564103 YBR002C RER2
SGTC_1231 0242-0792 125 µM 0.194745751358182 0.425343321224327 no 1377 0.422795996578282 1904 3707635
SGTC_330 1488-0319 80.1 µM 0.194557042108653 0.425411256543307 no 1378 0.422869867875376 1950 6846614
SGTC_1377 2944-0135 198 µM 0.193541752105265 0.425776798846393 no 1379 0.423267355344545 1961 1894137
SGTC_1423 4048-0112 5.59 µM 0.193288664484569 0.425867929783584 no 1380 0.423366451683573 2061 X1423
SGTC_1290 0986-0249 10.2 µM 0.193259439530682 0.425878453261549 no 1381 0.423377895012877 2069 53329
SGTC_2685 mycophenolic acid 18.85 µM 0.192741742706536 0.426064877050853 no 1382 0.423580615198311 2035 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2407 paclitaxel 400 µM 0.192534900182452 0.426139366130743 no 1383 0.423661616437579 1988 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1953 st076800 12.1 µM 0.192280898989974 0.42623084181166 no 1384 0.423761089813144 1856 297591
SGTC_3085 9117376 49.47 µM 0.192109791652736 0.426292466438024 no 1385 0.423828102570058 1976 16480349
SGTC_2246 7293507 91.5585 µM 0.191450282834482 0.426530006591581 no 1386 0.424086414271593 2095 887656
SGTC_941 3237-0776 460 µM 0.191239888607888 0.426605791442952 no 1387 0.424168826846589 2045 760008
SGTC_791 1348-1292 225 µM 0.189782748181052 0.427130733541476 no 1388 0.42473968758127 2036 5437054
SGTC_535 2293-4129 48.2 µM 0.189636393944306 0.427183465532238 no 1389 0.424797033206997 2071 396118 YIL048W NEO1
SGTC_989 1501-0895 10.3 µM 0.188847977110535 0.427467557491089 no 1390 0.425105984014837 2088 2830112
SGTC_3169 9102970 49.47 µM 0.188720713706003 0.4275134181211 no 1391 0.425155858058066 2049 17027839
SGTC_256 clotrimazole 625 nM 0.188378201982207 0.427636850481435 no 1392 0.425290093045304 2064 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_19 0279-0214 38.434 µM 0.188148418479421 0.427719662479054 no 1393 0.425380153170145 2015 3566274 YBR002C RER2
SGTC_614 0462-0418 107 µM 0.187460208080257 0.427967706622436 no 1394 0.42564990997265 2027 5188303
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.187056808135348 0.428113112890272 no 1395 0.42580804623397 2091 5024745
SGTC_2167 5876490 200 µM 0.186924339150986 0.428160863714535 no 1396 0.425859977823502 2077 686534
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.185923084165606 0.428521818030517 no 1397 0.426252539634027 1929 442882
SGTC_2266 7929956 200 µM 0.184479303304117 0.429042408975181 no 1398 0.426818731038681 2086 2967153
SGTC_1175 0741-0056 27.6 µM 0.182367239876897 0.429804187907472 no 1399 0.42764726672977 2067 765927
SGTC_2958 9077254 16.72 µM 0.182125459592239 0.429891409937395 no 1400 0.42774213449695 1972 16457351
SGTC_1516 st013856 110 µM 0.181976925194995 0.429944995290589 no 1401 0.42780041727866 2004 5281404 A mutagen and neurotoxin.
SGTC_184 1494-0393 24.714 µM 0.180671788075994 0.430415892673349 no 1402 0.4283126020919 1939 3090647
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.178249787492775 0.431290019506268 no 1403 0.429263405488638 2094 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1931 st074438 57.1 µM 0.177893986913321 0.431418460336856 no 1404 0.429403116637247 2104 2787313
SGTC_306 1672-3436 11.6 µM 0.177639849519598 0.431510206106223 no 1405 0.429502913422063 2029 6797378
SGTC_2732 terfenadine 20 µM 0.177369699512676 0.431607736617091 no 1406 0.429609003113002 2096 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2265 7929201 200 µM 0.176738385381054 0.431835672123971 no 1407 0.42985694414751 2071 1265108
SGTC_1942 st076330 65.2 µM 0.176473538513898 0.431931301654173 no 1408 0.429960967813436 2038 24208414
SGTC_2642 cholecalciferol 100 µM 0.176101910860068 0.432065493759788 no 1409 0.43010693986894 2076 9821465 A vitamin D precursor, similar to steriods.
SGTC_3047 9092122 49.47 µM 0.175945868857414 0.432121841755822 no 1410 0.430168234636396 1964 17173831
SGTC_671 0560-0003 407 µM 0.174916897506041 0.432493445935842 no 1411 0.43057246633831 2042 3238678
SGTC_1372 2752-0194 270 µM 0.173438200218544 0.433027569275945 no 1412 0.431153500316376 2044 823334
SGTC_2063 5246145 200 µM 0.173028789705615 0.433175474976069 no 1413 0.431314399002778 2038 711240
SGTC_637 1181-0519 7.26 µM 0.172349923187371 0.433420746326826 no 1414 0.431581219240231 2051 6252091 YGR060W ERG25
SGTC_2086 5274770 176.623 µM 0.17121600811489 0.433830481771279 no 1415 0.432026960349349 1988 689278
SGTC_2757 clomiphene 4.22 µM 0.170994539276073 0.433910516919833 no 1416 0.432114029692989 2124 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1403 3909-7815 62.9 µM 0.170245183066644 0.434181341844797 no 1417 0.432408659691282 2012 6615483
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.170203311889394 0.434196475424975 no 1418 0.432425123606276 2064 2346 DNA damaging agent; causes G2/M arrest.
SGTC_296 1222-0039 74.9 µM 0.169614631648294 0.434409253456866 no 1419 0.432656607448547 1980 5984176
SGTC_2801 7907800 81.82 µM 0.167504905848694 0.435171967919728 no 1420 0.433486393878207 1997 6620925
SGTC_3162 9099653 49.47 µM 0.167144406346668 0.435302321005438 no 1421 0.433628213115043 2108 25237511
SGTC_864 0469-0573 172 µM 0.167009833275406 0.435350983111631 no 1422 0.433681155879619 1925 689425
SGTC_1002 4049-0206 172 µM 0.165628161439057 0.435850657111238 no 1423 0.434224791879773 1999 4662749
SGTC_3348 9149464 3.537 µM 0.164430995715002 0.43628368833844 no 1424 0.434695932296033 2135 1951442
SGTC_3332 9141069 11.198 µM 0.162976020106645 0.436810075706474 no 1425 0.43526865770028 1960 17332883
SGTC_1616 st002734 56.1 µM 0.162088269286446 0.437131305065869 no 1426 0.435618171897207 2027 4026101
SGTC_2673 kobusone 100 µM 0.161292240598302 0.437419380365498 no 1427 0.435931617176581 2077 6710676 An epoxy ketone and protein crosslinker.
SGTC_2325 6158266 200 µM 0.16066447099867 0.437646587690503 no 1428 0.43617883693589 2009 3623240
SGTC_1971 st069429 63.5 µM 0.16039924156367 0.437742587802527 no 1429 0.4362832935145 2126 1246522 YGL099W LSG1
SGTC_3050 9093513 49.47 µM 0.158744447840308 0.438341624914422 no 1430 0.436935108925828 2078 25236664
SGTC_623 k072-0108 16.9 µM 0.15800075619395 0.438610888194667 no 1431 0.437228101422159 2038 5382803
SGTC_2966 9084041 48.03 µM 0.157299331129745 0.438864874348955 no 1432 0.437504473689127 1835 17741380
SGTC_152 4469-0003 551.229 µM 0.156872784811937 0.439019339171391 no 1433 0.437672554420089 2160 697280
SGTC_1651 st011928 86.1 µM 0.154961366066142 0.43971163319125 no 1434 0.438425887370434 2080 720198
SGTC_1013 4112-3890 241 µM 0.15495296237036 0.439714677322481 no 1435 0.438429199949926 1993 705171
SGTC_728 3030-5151 22.5 µM 0.154802013490623 0.439769357228885 no 1436 0.438488701905716 2042 3125388
SGTC_1515 3460-0031 42.1 µM 0.154460451098763 0.439893089446305 no 1437 0.43862334619608 2075 2876596
SGTC_1109 tnp00067 928.257 nM 0.154218847027588 0.439980614944759 no 1438 0.438718591091158 1992 676295
SGTC_3189 9110682 49.47 µM 0.151563210244508 0.4409428603855 no 1439 0.43976572604089 2008 17122418
SGTC_2219 9098279 200 µM 0.150644907252147 0.441275680429541 no 1440 0.440127917370625 2139 902349
SGTC_2111 5486399 200 µM 0.14928124089964 0.441769989725094 no 1441 0.440665858499421 2099 689674
SGTC_2533 agelasine 13.65 µM 0.149018637028499 0.441865190262213 no 1442 0.440769463470823 2158 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1781 st038725 66.3 µM 0.148483090149021 0.442059349936643 no 1443 0.440980765066189 1948 4270275 YIL048W NEO1
SGTC_802 4112-3352 742 µM 0.148387839213433 0.442093884116476 no 1444 0.441018348364552 2116 704594
SGTC_2090 5301565 104.445 µM 0.147591606060576 0.442382583604867 no 1445 0.441332539970713 2044 2056344
SGTC_92 0063-0024 660.874 µM 0.147412271614342 0.442447611202645 no 1446 0.441403309995459 2173 3594437
SGTC_571 k831-0106 44.2 µM 0.146823672136079 0.442661051305498 no 1447 0.441635599754383 2171 4783639
SGTC_1526 st051518 75 µM 0.145907762069297 0.442993215051537 no 1448 0.441997101962758 1992 673993
SGTC_2354 9060492 162 µM 0.144920039227618 0.443351467301362 no 1449 0.442387002221474 2120 6471895
SGTC_2815 7968870 71.43 µM 0.144776935484628 0.44340337562639 no 1450 0.442443496579007 2068 2977326 YHR190W ERG9
SGTC_1896 st058441 89 µM 0.144733481469975 0.443419137985811 no 1451 0.442460651544693 1997 688759
SGTC_3178 9107506 49.47 µM 0.142579089870244 0.444200726315862 no 1452 0.443311306301905 2104 8897194
SGTC_2172 5754775 163.918 µM 0.14254403076929 0.444213447154834 no 1453 0.443325151449313 2035 2263357
SGTC_1094 duloxetine 25.4 µM 0.142137692251533 0.444360887151827 no 1454 0.443485623148729 2044 60834 A selective serotonin reuptake inhibitor.
SGTC_2346 9031566 143.75 µM 0.141098859293584 0.444737862817126 no 1455 0.443895922394392 2118 4771086
SGTC_2451 5856223 45.7 µM 0.140550322299521 0.444936938201832 no 1456 0.444112597797433 2043 2179896
SGTC_2595 hexamethylquercetagetin 100 µM 0.140164148345521 0.445077097025226 no 1457 0.444265148849844 2059 386331
SGTC_1398 3558-0053 112 µM 0.138328431909244 0.445743449582469 no 1458 0.444990428044811 2063 4532369
SGTC_1914 st062367 72.6 µM 0.138260146420592 0.44576823971825 no 1459 0.445017410749416 2055 978205
SGTC_3001 9076041 71.4286 µM 0.135382439979342 0.446813144200292 no 1460 0.446154753586818 2120 16004211
SGTC_3027 9089541 49.47 µM 0.13535653492237 0.446822552098229 no 1461 0.446164993951344 2071 9943819
SGTC_2529 gangaleoidin 93.61 µM 0.135059970281523 0.446930257133705 no 1462 0.446282229604074 2087 4565183
SGTC_333 3486-0131 40.1 µM 0.134499361577872 0.447133867212168 no 1463 0.446503857945002 2173 6744690
SGTC_2963 9082507 9 µM 0.133786402054085 0.447392830415185 no 1464 0.446785740056598 2111 16459611
SGTC_47 0149-0135 24.25 µM 0.132865565608997 0.447727332445156 no 1465 0.447149850034663 2154 5239155
SGTC_3241 9133421 49.47 µM 0.132382073637123 0.447902980105171 no 1466 0.447341046522047 2175 17018221
SGTC_87 0100-0052 35.5 µM 0.131930907838032 0.448066893213796 no 1467 0.447519470690947 2148 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_107 0358-0022 2.6945 µM 0.131394790940871 0.448261681444706 no 1468 0.447731504583215 2152 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1991 st073000 8.92 µM 0.131285227808803 0.448301490733795 no 1469 0.447774838572497 2139 4301969 YIL048W NEO1
SGTC_957 1187-1561 14.1 µM 0.129502954813597 0.448949144734454 no 1470 0.448479843519228 2180 1538454
SGTC_2586 curcumin 80 µM 0.127684610850262 0.449610046644217 no 1471 0.449199284580263 2146 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2147 5545932 89.7195 µM 0.124879954746807 0.450629710636387 no 1472 0.45030929396165 2075 797404
SGTC_1637 st007924 17.4 µM 0.123952460719931 0.450966983475721 no 1473 0.450676457768832 2157 683336
SGTC_2883 9059145 45.46 µM 0.123898891755713 0.450986464314816 no 1474 0.450697665219248 2125 16476510
SGTC_448 monastrol 171 µM 0.122255248053993 0.451584247396792 no 1475 0.451348436469948 2159 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2656 pseudo-anisatin 100 µM 0.121689094131407 0.451790179581192 no 1476 0.451572625333539 2122 6708809 A neurotoxin.
SGTC_1489 4065-0444 182 µM 0.12135108888892 0.451913131412038 no 1477 0.451706477947855 2205 2877968
SGTC_1225 1216-0074 20.6 µM 0.121285282894729 0.451937069351091 no 1478 0.451732538254717 2077 4241466
SGTC_2032 5185112 25.99 µM 0.120511757353752 0.452218464198897 no 1479 0.452038883250975 2164 5718189
SGTC_463 ikarugamyin 104 µM 0.120443511222368 0.452243292083264 no 1480 0.452065912640795 2189 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_277 nystatin 15.5 µM 0.119967720299924 0.452416389599041 no 1481 0.452254359354619 2181 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1493 4348-0038 111 µM 0.118293889625272 0.453025417667837 no 1482 0.452917399389736 2185 800424
SGTC_2082 5219693 150 µM 0.117438594122896 0.453336662131122 no 1483 0.453256250984269 2158 2834649
SGTC_2472 5377652 49.4 µM 0.115866972141663 0.453908654431289 no 1484 0.453878985882359 2048 1610903
SGTC_35 0133-0054 64.071 µM 0.115597565613821 0.454006714652109 no 1485 0.453985746165803 2106 99677
SGTC_600 1495-0418 41.6 µM 0.115536621799181 0.454028897740203 no 1486 0.45400989741145 2116 5377768
SGTC_3307 9126885 69.2785 µM 0.11551962634405 0.454035083983044 no 1487 0.454016632520869 2078 24824909
SGTC_473 2-arachidonoylglycerol 10 µM 0.113885546073982 0.454629931173782 no 1488 0.454664261788295 2030 5282280 An endocannabinoid.
SGTC_2969 9091408 28.7 µM 0.113674316560496 0.454706831597766 no 1489 0.454747986469626 1957 4286311
SGTC_2840 9008771 71.43 µM 0.113562647873798 0.454747486495558 no 1490 0.454792249208729 2204 2992978
SGTC_3253 9135987 49.47 µM 0.113016797359091 0.454946219537165 no 1491 0.455008619084184 2163 4182430
SGTC_2138 5575593 77.673 µM 0.112973101488639 0.454962128800707 no 1492 0.455025940283362 2151 762213
SGTC_978 1416-0512 87.4 µM 0.112519843872421 0.455127159975972 no 1493 0.455205618259614 2114 6814003
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.111969021585385 0.455327724886221 no 1494 0.455423984635846 2186 6708784 An antioxidant flavonoid
SGTC_658 3253-0951 102 µM 0.111726493969037 0.455416037434859 no 1495 0.455520135849038 2132 1184878
SGTC_1202 1988-0068 29.6 µM 0.111084892757499 0.455649676856223 no 1496 0.455774514212982 2052 2850480
SGTC_518 1021-0119 62.6 µM 0.111081344773376 0.455650968899242 no 1497 0.455775920947856 2009 1097762
SGTC_444 curcumin 90.4 µM 0.110627374604202 0.455816291707777 no 1498 0.455955919463241 2173 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3152 9099253 49.47 µM 0.11040927998293 0.45589571818473 no 1499 0.456042396882053 2170 25236131
SGTC_3298 9116858 71.43 µM 0.110105529815753 0.456006341940086 no 1500 0.456162841333206 2168 2506942
SGTC_2095 5432005 200 µM 0.109941003787765 0.456066262630575 no 1501 0.45622808165359 2154 783734
SGTC_1107 amlodipine 47 µM 0.109115968180322 0.4563667572004 no 1502 0.456555254868578 2170 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2636 apigenin dimethyl ether 100 µM 0.108646427185895 0.45653778463292 no 1503 0.456741467557643 2136 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.108546455949697 0.456574199584377 no 1504 0.456781115830183 2072 61125 An anti-inflammatory.
SGTC_2904 7225135 42.03 µM 0.105385876152762 0.457725640754986 no 1505 0.458034811425529 2231 4446116
SGTC_2776 terbinafine 19.92 µM 0.103676962432121 0.45834836915308 no 1506 0.458712854714664 2228 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3121 9125696 49.47 µM 0.103209422494778 0.458518758648807 no 1507 0.458898380890794 2246 1235365
SGTC_2101 5377231 179.231 µM 0.101559613830525 0.459120072933277 no 1508 0.45955311856558 2169 2844213
SGTC_2697 mebhydrolin 72.4 µM 0.101212008988529 0.459246778241878 no 1509 0.459691081939495 2198 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2731 amoxapine 43.43 µM 0.101094676139794 0.459289548129055 no 1510 0.459737652110254 2257 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3123 9126162 49.47 µM 0.0996152826297606 0.459828853345638 no 1511 0.460324880197013 2216 25239884
SGTC_516 3992-2719 87.3 µM 0.099325216273235 0.459934604227383 no 1512 0.460440028859463 2210 5350887 YDR037W KRS1
SGTC_1135 dihydrocapsaicin 536.708 nM 0.098317388032133 0.46030205498392 no 1513 0.460840135710243 2187 107982 A Capsaicinoid.
SGTC_534 k292-0788 63.4 µM 0.0969365910411469 0.460805543865935 no 1514 0.461388375089326 2270 4146317
SGTC_2213 7173844 200 µM 0.0947440057082087 0.461605169144286 no 1515 0.462259081832894 2225 892728
SGTC_2431 5490079 200 µM 0.094476535857665 0.461702724794684 no 1516 0.462365310367899 2166 5722345
SGTC_2360 9040895 200 µM 0.0938214342987991 0.461941673067726 no 1517 0.462625502338932 2147 4914414
SGTC_3243 9134147 49.47 µM 0.0938137501260557 0.461944475951173 no 1518 0.462628554418922 2253 24282180
SGTC_2207 7258803 200 µM 0.0937174568842379 0.461979600091868 no 1519 0.462666801360951 2218 3666799
SGTC_346 4513-0042 7.16 µM 0.0920653615033179 0.462582268096482 no 1520 0.463323054525556 2221 2827372
SGTC_2942 9052777 62.25 µM 0.0915320293663588 0.462776840777904 no 1521 0.463534928646917 2187 6469503
SGTC_84 0443-0269 128.823 µM 0.0914925864825847 0.462791230866308 no 1522 0.463550598330451 2240 6150058
SGTC_1433 4060-0023 7.6 µM 0.0913678660680236 0.462836733381706 no 1523 0.463600147042709 2210 3840627
SGTC_3285 9112818 20.8695 µM 0.0909054593535838 0.463005440304358 no 1524 0.463783856110033 2244 17017947 YPR165W RHO1
SGTC_2749 bexarotene 57.39 µM 0.0908987981535237 0.463007870660674 no 1525 0.463786502587573 2144 82146 An retinoic acid receptor inhibitor.
SGTC_1864 st057645 30.4 µM 0.0908739172798712 0.463016948524902 no 1526 0.463796387708438 2258 688666
SGTC_3067 9117431 49.47 µM 0.0907578596193166 0.46305929277811 no 1527 0.463842497477823 2150 17150885
SGTC_2780 5215298 71.43 µM 0.0905774447456185 0.463125118932901 no 1528 0.46391417736585 2272 2834131
SGTC_416 estradiol valerate 100 µM 0.0905387856265553 0.463139224227069 no 1529 0.463929537013183 2140 13791 A steroid.
SGTC_469 w7 172 µM 0.0902692055221725 0.463237585403801 no 1530 0.464036645327106 2251 45115570 A P450 inhibitor.
SGTC_2519 cryptotanshinone 88.04 µM 0.0902316730079736 0.463251279998799 no 1531 0.464051557778059 2229 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1070 indatraline 8.81 µM 0.0900367334481653 0.463322408849496 no 1532 0.464129012144184 2139 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_814 3342-0569 96 µM 0.0899220505386906 0.463364254488076 no 1533 0.464174579169771 2242 4346283
SGTC_997 3996-0078 137 µM 0.0898137347120512 0.46340377727001 no 1534 0.46421761679023 2181 735687
SGTC_1683 st010134 710 nM 0.089260649496427 0.463605595195405 no 1535 0.464437383173164 2228 3818134
SGTC_121 0557-0495 61.343 µM 0.0877696704686056 0.464149692218549 no 1536 0.465029872083997 2233 3104427
SGTC_2401 5128683 200 µM 0.0869678081890398 0.464442340411223 no 1537 0.465348550235426 2193 708373
SGTC_2298 7976326 193.81 µM 0.0851222753383412 0.465115960141091 no 1538 0.466082090708494 2212 2235818
SGTC_148 3253-0744 288.01 µM 0.0851209745543674 0.465116434962896 no 1539 0.466082607769589 2272 6893655
SGTC_1448 4255-0083 152 µM 0.0840481228807512 0.46550807208143 no 1540 0.466509085283895 2243 5399660
SGTC_930 2810-3379 265 µM 0.0828890203562136 0.465931232014505 no 1541 0.4669698922418 2278 1015764
SGTC_42 0133-0086 60.653 µM 0.082695316566955 0.466001952291664 no 1542 0.467046904478422 2247 162923 Model of phenazepam hydroxylation.
SGTC_603 3794-0023 45.9 µM 0.0796392393653177 0.467117851310802 no 1543 0.468262092906984 2262 3802260
SGTC_1673 st016611 27.3 µM 0.0790382519011626 0.46733732715254 no 1544 0.468501098800231 2223 5226799
SGTC_2936 9038235 15.59 µM 0.0778370616599811 0.467776021967235 no 1545 0.468978832462787 2266 4749415
SGTC_698 k064-0052 127 µM 0.0769992521244645 0.46808202725754 no 1546 0.469312069960555 2281 5088751
SGTC_1900 st060200 72.8 µM 0.0767823443807823 0.46816125468982 no 1547 0.469398348206044 2246 688945
SGTC_703 3875-0075 71.8 µM 0.0764385082901625 0.468286846382963 no 1548 0.469535117011139 2205 2850814
SGTC_1242 0402-0103 60.1 µM 0.0745625082801862 0.468972140993698 no 1549 0.470281402554225 2257 432868
SGTC_69 0096-0274 206.684 µM 0.0744054401925986 0.4690295214792 no 1550 0.470343890078474 2214 6741392
SGTC_143 4032-1194 15.74 µM 0.0730134961789413 0.469538057735974 no 1551 0.470897688889428 2258 1806963
SGTC_2695 st077686 51.995 µM 0.0723306011117817 0.469787566525345 no 1552 0.471169406151152 2205 2876092
SGTC_2164 5685496 200 µM 0.0714947323319668 0.470092983327715 no 1553 0.471502008410871 2274 759046
SGTC_2693 st077581 40.7 µM 0.0710812387396489 0.470244075628839 no 1554 0.471666549856799 2298 25238761
SGTC_2764 methyldopa 94.69 µM 0.0703439199053172 0.470513505654539 no 1555 0.471959963017194 2271 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1846 st056244 14.8 µM 0.0698328181230084 0.470700279688144 no 1556 0.472163362922732 2214 5393182
SGTC_2888 9058547 12.99 µM 0.069252651224768 0.470912300280658 no 1557 0.472394257025215 2265 16476514
SGTC_2466 5983409 37.09 µM 0.069032737202179 0.470992669487648 no 1558 0.472481780564034 2167 2879657
SGTC_2644 guaiazulene 100 µM 0.0688953253648057 0.47104288826045 no 1559 0.472536469749081 2261 3515 A coloring agent.
SGTC_2104 5389443 200 µM 0.0674749427219149 0.471562010644534 no 1560 0.473101804682484 2251 2244536
SGTC_2326 6164455 177.58 µM 0.067015531163479 0.471729927067993 no 1561 0.47328466945778 2234 2888790
SGTC_815 1582-0027 36.9 µM 0.0657835676626505 0.472180238471105 no 1562 0.473775069500364 2241 3128206
SGTC_3274 9138298 49.47 µM 0.0649648665902695 0.472479512519782 no 1563 0.474100986768715 2306 17015756
SGTC_466 geldanamycin 89.2 µM 0.0649634567045553 0.47248002791329 no 1564 0.474101548046095 2301 5288382 HSP90 inhibitor.
SGTC_553 k007-0256 45.7 µM 0.0646863211843342 0.472581337619635 no 1565 0.474211877062501 2223 6287000
SGTC_368 fentichlor 4.58 µM 0.0638068290439571 0.472902856626474 no 1566 0.474562020275631 2208 7329 A pesticide.
SGTC_777 1315-0167 517 µM 0.0632439100538486 0.473108654163221 no 1567 0.474786139787669 2110 4221767
SGTC_1046 2001-0062 216 µM 0.0631999532457787 0.473124724634217 no 1568 0.47480364100565 2249 739778
SGTC_1180 1193-0155 285 µM 0.0627131795824103 0.473302690475438 no 1569 0.474997451132155 2230 2921347
SGTC_2294 7971431 200 µM 0.0619576692273627 0.473578917759367 no 1570 0.475298271131899 2261 5741572
SGTC_2813 7971799 71.43 µM 0.0610914635325708 0.47389563274497 no 1571 0.475643183784024 2246 2234054
SGTC_666 0272-0154 136 µM 0.06053009751877 0.474100896545174 no 1572 0.47586672271842 2230 6870312
SGTC_9 0092-0002 10.449 µM 0.0598653038897344 0.474343987599801 no 1573 0.47613145689812 2299 759368
SGTC_1325 1431-0015 227 µM 0.0575893196060785 0.475176304753055 no 1574 0.477037878636926 2268 1103340
SGTC_842 0271-0008 11.1 µM 0.0570446255689972 0.475375513101043 no 1575 0.477254823465274 2281 1221709
SGTC_3116 9124943 49.47 µM 0.0565567574045497 0.475553944021504 no 1576 0.477449140983332 2262 41905195 YPL160W CDC60
SGTC_1039 k821-0043 94 µM 0.0542870780646754 0.476384111209862 no 1577 0.478353222291362 2292 15992768
SGTC_958 1222-0007 33 µM 0.054260392771441 0.476393872348517 no 1578 0.478363852515165 2292 7312461
SGTC_625 k213-0058 121 µM 0.0533726613196868 0.476718601187205 no 1579 0.478717493631355 2249 3655420
SGTC_2505 galangin 7.89 µM 0.0531513840801563 0.476799545987901 no 1580 0.478805645352696 2279 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_454 lyso-paf C-16 6.67 µM 0.052428386084021 0.477064030494735 no 1581 0.479093678195069 2246 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1243 0416-0003 5.65 µM 0.0524267892320075 0.477064614660577 no 1582 0.479094314371937 2253 2141977
SGTC_2426 5582046 32.21 µM 0.0522609218040246 0.477125293116145 no 1583 0.479160395312891 2300 2251934
SGTC_783 0848-0141 92.7 µM 0.0508606046186127 0.477637585181852 no 1584 0.479718298908711 2315 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2862 9027634 71.43 µM 0.0500080678644347 0.477949495396503 no 1585 0.480057979570792 2292 5012562
SGTC_1505 k297-0037 20.6 µM 0.0495907529003962 0.478102179732271 no 1586 0.480224257841602 2279 4089396
SGTC_3329 9141233 27.5565 µM 0.049239604743405 0.478230657901622 no 1587 0.480364174754316 2298 4909101 YNL103W MET4
SGTC_198 3454-2873 16.191 µM 0.048136313394288 0.478634345055868 no 1588 0.480803802916789 2278 710957
SGTC_1420 4'-methoxyflavone 42 µM 0.0481200938236149 0.478640279856164 no 1589 0.480810266099551 2319 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_81 0411-0046 9.971 µM 0.0473444784672431 0.478924085859282 no 1590 0.481119339558149 2323 12925265
SGTC_2944 9067346 25.62 µM 0.0472663837137707 0.478952662164289 no 1591 0.48115046001695 2285 6473075
SGTC_1126 isoteolin 1.0172 µM 0.0467717069162847 0.479133675999545 no 1592 0.48134758947813 2324 133323
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.0467523463287906 0.479140760580075 no 1593 0.48135530479495 2184 688788
SGTC_1053 3366-3204 134 µM 0.0463774513138973 0.479277946449435 no 1594 0.481504704207785 2270 3632071 YPR165W RHO1
SGTC_1280 0880-0253 10.1 µM 0.0442993620147653 0.48003842871283 no 1595 0.48233289010771 2283 6836607
SGTC_1702 st027038 51 µM 0.0441917786390024 0.4800778011352 no 1596 0.482375767674328 2250 5521182
SGTC_1189 1431-2119 7.28 µM 0.0433924248925076 0.480370347685497 no 1597 0.482694358037775 2334 3107275
SGTC_1162 k048-0130 20.1 µM 0.0432401726797683 0.480426069975965 no 1598 0.482755040926245 2291 6797406
SGTC_879 0831-1030 162 µM 0.0423250707228858 0.480760993174675 no 1599 0.483119779821804 2330 1549252
SGTC_738 1315-0003 72.4 µM 0.0422378025379543 0.480792933650762 no 1600 0.483154563684695 2316 6251474
SGTC_2798 7813637 45.45 µM 0.0419631511340225 0.480893457876747 no 1601 0.483264036681034 2300 956368
SGTC_2432 5630864 12.22 µM 0.0414283197879339 0.481089213159056 no 1602 0.483477218123138 2291 5714970
SGTC_1547 harmine 94.2 µM 0.0401407030141587 0.481560516388304 no 1603 0.483990475811807 2331 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1223 0764-0573 147 µM 0.0400504486239107 0.481593552957024 no 1604 0.484026453172835 2334 1609797
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.0396702809878066 0.481732710278841 no 1605 0.484177997677129 2317 2333 A French combination drug.
SGTC_1836 st055642 81 µM 0.0391477394030637 0.481923986074297 no 1606 0.484386299789473 2322 8571
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.0389274262942683 0.482004632704767 no 1607 0.484474125057912 2343 6708561
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.0376462247387824 0.482473636936465 no 1608 0.484984876005925 2343 756377
SGTC_639 0833-0042 114 µM 0.0367175663209154 0.482813602338 no 1609 0.485355101094235 2301 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_389 tpck 16.7 µM 0.0366298459991005 0.482845715844218 no 1610 0.485390072913675 2305 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1065 prochlorperazine maleate 2.48 µM 0.0349199518206602 0.483471712461296 no 1611 0.486071785531168 2348 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2839 9003951 25.97 µM 0.0336520762997202 0.483935911314282 no 1612 0.486577297439183 2372 2990634
SGTC_2211 7117706 200 µM 0.0336380157579762 0.483941059330383 no 1613 0.48658290360981 2349 822771
SGTC_1937 st074714 47.2 µM 0.0326774143670372 0.48429277265724 no 1614 0.486965917497409 2336 17250970
SGTC_794 k038-0031 316 µM 0.0324934647540775 0.484360125128667 no 1615 0.487039263825077 2340 6624242
SGTC_2146 5545642 200 µM 0.0322963108325669 0.484432312804289 no 1616 0.487117875600434 2334 825326
SGTC_3299 9121982 43.1275 µM 0.0321879183190059 0.4844720008127 no 1617 0.487161095486411 2323 17594604 YPL160W CDC60
SGTC_2406 ethylparaben 405.7 µM 0.0319723419617792 0.48455093473088 no 1618 0.487247053767088 2272 8434 A possible steroid mimic.
SGTC_413 propylparaben 100 µM 0.0317883833588863 0.484618292194029 no 1619 0.487320405346335 2324 7175 A pharmaceutical preservative.
SGTC_2790 5423970 71.43 µM 0.0299466783866131 0.485292666564369 no 1620 0.488054789278566 2331 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2784 7567673 72.73 µM 0.0286131375095018 0.485780993611786 no 1621 0.488586567078826 2354 3471247
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0276111288318526 0.486147931521975 no 1622 0.488986152763069 2330 688761
SGTC_363 0455-0021 3.06 µM 0.0274388639705647 0.486211016505308 no 1623 0.489054850471085 2357 4597466
SGTC_2387 9077560 195.08 µM 0.0269177709099926 0.486401847691386 no 1624 0.489262659758144 2362 5303272
SGTC_1757 st041620 31.8375 µM 0.0258137597103159 0.486806161460203 no 1625 0.489702943422399 2321 5289815
SGTC_881 0833-0569 170 µM 0.0255316194073034 0.486909489786616 no 1626 0.489815464031357 2334 5418700
SGTC_297 0986-0032 24 µM 0.0237611080477866 0.487557924466544 no 1627 0.49052158128275 2357 2847425
SGTC_2873 9040596 71.43 µM 0.0228869733597418 0.487878081073856 no 1628 0.490870215714121 2244 6463863
SGTC_2701 st077767 14.721 µM 0.022319150698154 0.488086053425511 no 1629 0.49109668631943 2351 5721188
SGTC_1687 st020778 55.3625 µM 0.022134256868308 0.488153773870269 no 1630 0.491170430067509 2345 4259299
SGTC_1764 st044502 93.5 µM 0.0219517753456247 0.488220611102254 no 1631 0.491243211977883 2344 8407
SGTC_3317 9138495 8.753 µM 0.0213429507300719 0.488443606758142 no 1632 0.491486040952121 2362 17020139
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.0184741066724862 0.489494432630274 no 1633 0.492630316961152 2299 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1835 st008666 49.2 µM 0.0174308240726804 0.489876593982527 no 1634 0.493046459416862 2361 690455
SGTC_772 k072-0172 35.3 µM 0.0173632534669172 0.489901345868873 no 1635 0.493073412109389 2360 5861980
SGTC_2113 5491891 107.031 µM 0.0159338750522566 0.490424952506587 no 1636 0.493643572522666 2371 789979
SGTC_2947 9072639 7.68 µM 0.0145525980058255 0.490930954447973 no 1637 0.494194558277425 2376 16488146
SGTC_2171 5739187 198.077 µM 0.0145352067260055 0.490937325474152 no 1638 0.494201495660502 2374 2262761
SGTC_3296 9122258 64.045 µM 0.014167746269671 0.491071939462736 no 1639 0.494348076076098 2372 4730474
SGTC_1139 k015-0024 46.9 µM 0.0137805479848737 0.491213785228142 no 1640 0.494502530760395 2377 2766652
SGTC_1818 st052136 56.3 µM 0.0133567747951206 0.491369031074179 no 1641 0.494671576239746 2363 674169
SGTC_922 1866-0035 480 µM 0.0125191132396826 0.491675905365598 no 1642 0.495005726873134 2362 3156169
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.0122429949700341 0.491777061386974 no 1643 0.495115873682385 2364 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3306 9127676 59.7925 µM 0.0122371079583337 0.49177921810148 no 1644 0.495118222084334 2368 41905287
SGTC_3044 9093193 49.47 µM 0.0116647712862876 0.491988895534449 no 1645 0.495346535073343 2372 25236277
SGTC_2961 9083290 32.55 µM 0.0110514254339162 0.492213599271929 no 1646 0.495591208879775 2392 17741490
SGTC_2959 9079155 11 µM 0.0108753583945243 0.4922781031787 no 1647 0.495661445244692 2375 16189457
SGTC_2692 st077426 47.7 µM 0.010577653726353 0.492387170696109 no 1648 0.495780205391115 2384 25238571
SGTC_2655 perillic acid 100 µM 0.00951276982903558 0.492777307719001 no 1649 0.496205011148078 2369 5702197 An apoptosis inducer.
SGTC_2534 helenine 20.12 µM 0.00863368044733691 0.493099381211051 no 1650 0.496555702624041 2389 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_275 trichlorophene 5.69 µM 0.00769063222481171 0.493444892409577 no 1651 0.496931911886635 2357 62616
SGTC_2259 7964009 200 µM 0.00735594579832733 0.493567515021274 no 1652 0.497065428673642 2359 313134
SGTC_2453 5731132 22.18 µM 0.00685665792619413 0.49375044553458 no 1653 0.497264610684497 2390 1362040
SGTC_2821 7996764 71.43 µM 0.00660993979613723 0.493840839313646 no 1654 0.497363034746502 2392 2987135
SGTC_1193 1488-0126 41.5 µM 0.0046365060628575 0.494563886480393 no 1655 0.498150308325386 2396 1384710
SGTC_767 0929-0023 86 µM 0.00450199780420412 0.494613169691512 no 1656 0.498203968796619 2390 1204563
SGTC_66 0109-0187 42.4 µM 0.00440122967722768 0.494650090726525 no 1657 0.498244169064646 2397 759417
SGTC_2504 purpurogallin 52.29 µM 0.00341157539143998 0.495012698448237 no 1658 0.498638980973693 2400 5281571 An antioxidant.
SGTC_789 1309-1135 70.6 µM 0.00340526129972552 0.495015011934726 no 1659 0.498641499917209 2399 3092424
SGTC_23 0213-0011 39.996 µM 0.0019897368434619 0.495533664917691 no 1660 0.499206210370046 2401 627608
SGTC_295 k015-0027 31 µM 0.00149169190748502 0.495716152119398 no 1661 0.499404901249468 2401 3887424
SGTC_3039 9090270 49.47 µM 0.000850314221015921 0.495951158773975 no 1662 0.499660773746489 2403 17173750
SGTC_1579 chlormadinone acetate 49.4 µM 0.000499135444356094 0.496079834492434 no 1663 0.499800873775868 2404 45114258 A steroidal progestin.
SGTC_689 0833-0039 98 µM 0 0.496262723839693 no 1664 0.5 2406 5374726
SGTC_1250 0485-0349 40.2 µM -0.00141178898437612 0.496780024761125 no 1665 0.499436777870225 2413 6842794 YDL195W SEC31
SGTC_1485 3909-9022 254 µM -0.00245338171012364 0.497161683671672 no 1666 0.499021243287738 2411 714516
SGTC_721 1187-1332 279 µM -0.00454708316115754 0.497928862253561 no 1667 0.498185982525609 2415 25730
SGTC_2481 5478948 45.16 µM -0.00479909652222594 0.498021206103067 no 1668 0.498085444838684 2421 77792
SGTC_2557 derrustone 83.84 µM -0.00528231249933303 0.498198268529228 no 1669 0.497892672005795 2430 629853 An antioxidant.
SGTC_2915 7971052 15.16 µM -0.00564254172180782 0.498330265763673 no 1670 0.497748963483102 2421 5741558
SGTC_2381 9035592 200 µM -0.00617007290840684 0.498523567058344 no 1671 0.497538512661742 2426 4749657
SGTC_318 1488-0629 67.2 µM -0.00676020720617752 0.498739808187325 no 1672 0.497303088062857 2430 3662576
SGTC_2044 5102272 200 µM -0.00806368012803275 0.499217437055952 no 1673 0.496783091923468 2428 592666
SGTC_1293 1000-1278 195 µM -0.00831650146424972 0.499310078002933 no 1674 0.496682234186036 2427 678847
SGTC_2846 9008642 19.48 µM -0.00835636927505906 0.499324686709198 no 1675 0.496666329783335 2433 2992898
SGTC_1619 st003326 88.7 µM -0.00867057978391101 0.499439822457484 no 1676 0.496540982469545 2423 2849032
SGTC_2447 5741742 33.78 µM -0.00941278551818186 0.499711788107811 no 1677 0.496244897331211 2437 1776504
SGTC_606 k015-0008 38.6 µM -0.01012024283048 0.499971021057703 no 1678 0.495962676163767 2431 1970475
SGTC_1789 tunicamycin 25 nM -0.0102784122505062 0.499971021057703 no 1679 0.495899578976686 2439 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_771 0250-0039 27.3 µM -0.0104240234115629 0.499917664885658 no 1680 0.495841491640139 2424 3005115
SGTC_1734 st037168 69.4 µM -0.011569612073782 0.499497887948693 no 1681 0.495384495544924 2453 708907
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.0118990039324084 0.499377189293446 no 1682 0.495253096253049 2432 688662
SGTC_3320 9137005 35.139 µM -0.0128066286619714 0.499044609804056 no 1683 0.494891034011082 2436 4908713
SGTC_1614 st002383 48.6 µM -0.0142685487881057 0.498508922227055 no 1684 0.49430786575412 2425 1947235
SGTC_1380 2291-0730 164 µM -0.014527327495377 0.498414098873086 no 1685 0.494204638686882 2441 2999191
SGTC_742 0kpi-0133 140 µM -0.0163087697670434 0.49776133408456 no 1686 0.493494030605127 2441 2728852
SGTC_778 3456-2434 196 µM -0.0175020418647592 0.497324092731752 no 1687 0.493018051962042 2449 5539063
SGTC_422 cantharidin 155 µM -0.0175818064713459 0.497294865320218 no 1688 0.492986235383664 2428 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2450 5739737 12.93 µM -0.0186402660772621 0.49690702513245 no 1689 0.492564040362168 2448 2262825
SGTC_2237 6667747 47.222 µM -0.0195405332488859 0.496577152015855 no 1690 0.492204951175671 2463 729940 YDL015C TSC13
SGTC_489 paxilline 115 µM -0.0200508586548455 0.496390161181592 no 1691 0.492001400683209 2467 105008 A toxic potassium channel blocker.
SGTC_393 acivicin 6.25 µM -0.0208214499502311 0.496107806562836 no 1692 0.491694043430664 2458 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2983 9022671 12.99 µM -0.0211708316141215 0.495979789235623 no 1693 0.491554691032946 2461 6405161
SGTC_1168 k815-0004 80.5 µM -0.0218548951131315 0.495729141972931 no 1694 0.491281852328661 2444 642433
SGTC_2427 5545055 42.75 µM -0.0230268064882595 0.495299746659519 no 1695 0.490814445065026 2449 5372858
SGTC_598 3937-0236 20.2 µM -0.0235308693918304 0.495115056652832 no 1696 0.490613407541867 2459 1379313
SGTC_2306 7482397 179.52 µM -0.0236652004462966 0.49506583756742 no 1697 0.490559832123984 2454 891448
SGTC_3114 9122766 49.47 µM -0.0244824794496474 0.494766387048535 no 1698 0.490233879450317 2485 17176985
SGTC_1021 4476-0760 85.3 µM -0.0246407574847838 0.494708394410454 no 1699 0.490170754693714 2450 746768
SGTC_1788 fluconazole 20 µM -0.0251158944743622 0.494534306196928 no 1700 0.489981261112181 2514 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3238 9133470 49.47 µM -0.0257729010948931 0.494293583430094 no 1701 0.489719238230272 2458 3534688
SGTC_175 3793-3120 23.7 µM -0.0283107819139893 0.493363741423374 no 1702 0.488707140661927 2466 5322297
SGTC_1728 st035614 33.7865 µM -0.0283325528000255 0.493355765041396 no 1703 0.488698458817631 2562 15945546
SGTC_845 0330-0138 4.51 µM -0.0284806600630281 0.493301501812844 no 1704 0.48863939640302 2443 9039800
SGTC_27 0485-0001 32.618 µM -0.0287052035283409 0.493219234285458 no 1705 0.488549853131897 2451 2054479
SGTC_2022 5136654 200 µM -0.0294088685997838 0.492961429577637 no 1706 0.488269249872708 2500 1713771
SGTC_1968 st069590 43.6 µM -0.0298153313597307 0.492812513453224 no 1707 0.488107165772919 2461 6384066
SGTC_32 0928-0142 34.1 µM -0.0305054371631848 0.49255968107876 no 1708 0.487831978585741 2471 2244242
SGTC_366 0181-0206 4.31 µM -0.0305593508180557 0.492539928989522 no 1709 0.487810480172362 2466 274874
SGTC_3237 9133362 49.47 µM -0.0307736575453694 0.492461414634746 no 1710 0.487725024350275 2453 43845137
SGTC_1041 0206-0046 107 µM -0.0319645971094304 0.492025102185703 no 1711 0.487250141937713 2545 50494
SGTC_2566 crystal violet carbinol 226 nM -0.0320552610651398 0.491991886936048 no 1712 0.487213990778112 2552 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_962 1254-0300 21.5 µM -0.0321204047649232 0.491968021209831 no 1713 0.487188015577824 2456 7340576
SGTC_1279 0874-0590 65.2 µM -0.0324463892705759 0.491848595559457 no 1714 0.487058034328371 2511 3523074
SGTC_1011 4112-3381 17.4 µM -0.0339259275501464 0.491306570485667 no 1715 0.486468108945051 2583 2877139
SGTC_1295 1013-0063 9.78 µM -0.0340079562143201 0.491276519954274 no 1716 0.486435403115386 2473 6826038
SGTC_3103 9120822 49.47 µM -0.0346330555807917 0.491047521543674 no 1717 0.486186171380609 2460 17141819
SGTC_1622 st003707 19.4 µM -0.0349085328072051 0.490946604365316 no 1718 0.486076338282678 2551 10140899
SGTC_3255 9139072 49.47 µM -0.0357407053853859 0.490641753279194 no 1719 0.485744556534204 2512 17646060
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.0358909793522024 0.490586703758679 no 1720 0.485684644334503 2484 6857784
SGTC_1685 st024049 53.0905 µM -0.036279127750082 0.490444515071043 no 1721 0.4855298963124 2509 1941139
SGTC_2108 5365811 200 µM -0.0370788556900745 0.490151558116718 no 1722 0.485211065574176 2514 780283
SGTC_708 3448-5400 146 µM -0.0381205532636523 0.489769970651114 no 1723 0.484795782042232 2465 3462195
SGTC_1328 1441-0025 69.2 µM -0.0386762752875668 0.489566406202475 no 1724 0.484574244415579 2466 4562601
SGTC_1149 3909-7961 23.3 µM -0.0416705474760595 0.488469633702142 no 1725 0.48338066663417 2491 735261
SGTC_219 mitoxanthrone 164.414 µM -0.0417230653142484 0.488450397687529 no 1726 0.483359733253591 2531 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_120 rhodamine 6G 52.259 µM -0.0430913768472806 0.487949227849816 no 1727 0.482814346597514 2495 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2056 5235370 200 µM -0.0439121669443438 0.487648607117442 no 1728 0.482487208418949 2506 5511916
SGTC_2368 9071271 200 µM -0.0441609832540634 0.487557477594543 no 1729 0.482388041273289 2511 27209959
SGTC_695 3505-6186 243 µM -0.0442811358544077 0.487513471671645 no 1730 0.482340154165507 2525 1819379
SGTC_2323 6148992 148.28 µM -0.0449595130067343 0.487265018721 no 1731 0.482069790120379 2526 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_688 0527-0193 473 µM -0.0459297198006719 0.486909692930894 no 1732 0.481683133095494 2522 4007154
SGTC_1212 0520-0165 585 µM -0.0488739612223718 0.485831467072499 no 1733 0.480509869995333 2569 5403258
SGTC_785 1270-0111 65.3 µM -0.0504162444989003 0.485266700386501 no 1734 0.479895345804897 2490 6741994
SGTC_34 0469-0683 81.75 µM -0.05058537949331 0.485204766842889 no 1735 0.47982795669173 2551 3690923
SGTC_2049 5262831 67.185 µM -0.0513310618847369 0.484931718501161 no 1736 0.479530858458912 2511 763417
SGTC_2037 5169046 200 µM -0.0515741864313033 0.484842694513495 no 1737 0.479433994101039 2567 5718022
SGTC_1267 0828-0272 9.49 µM -0.0518193184774475 0.484752936212256 no 1738 0.479336331155787 2522 745334
SGTC_439 amiodarone 34.4 µM -0.0520228333838644 0.484678417157198 no 1739 0.479255249818213 2595 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_874 0599-0792 117 µM -0.0539382461407941 0.4839770958497 no 1740 0.478492182494583 2495 765305
SGTC_1820 st053765 18.6 µM -0.0540472396521475 0.483937189748047 no 1741 0.47844876370836 2547 3690829
SGTC_2912 7964298 10.93 µM -0.0548918414566147 0.483627958792431 no 1742 0.478112315827626 2547 2975850
SGTC_3174 9107204 49.47 µM -0.0552425616222271 0.483499553789668 no 1743 0.477972610707023 2542 3938802
SGTC_3280 9140961 49.47 µM -0.0562056479726544 0.483146959280829 no 1744 0.477588990923012 2509 4901226
SGTC_1984 st072354 53.1 µM -0.0562820835416308 0.483118976097707 no 1745 0.477558545735664 2528 5762938
SGTC_2670 beta-carotene 100 µM -0.0567200833902837 0.482958625265617 no 1746 0.477384087768383 2516 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1257 0669-0121 16 µM -0.0568517642231445 0.482910417724782 no 1747 0.477331639348549 2577 4307855
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.0568609166368477 0.482907067091846 no 1748 0.477327993960639 2535 390807
SGTC_1527 coumarin 137 µM -0.0572559461442163 0.482762450779462 no 1749 0.477170656317035 2706 323 A hepatotoxic, DNA x-linker.
SGTC_1255 0566-0045 221 µM -0.0574934265716544 0.482675512684109 no 1750 0.477076071142497 2581 2788469
SGTC_722 3534-0461 190 µM -0.057718946060501 0.482592954075151 no 1751 0.476986251040019 2535 658262
SGTC_1920 st075728 45.7 µM -0.0577743654258581 0.482572666161224 no 1752 0.476964178744705 2517 3400306
SGTC_656 4090-1979 187 µM -0.0583543440032331 0.482360350397734 no 1753 0.476733190484991 2507 22330961
SGTC_891 0929-0073 133 µM -0.0594842866638909 0.481946720853838 no 1754 0.476283190369883 2654 5603632
SGTC_2006 4011487 200 µM -0.0603719993543876 0.481621776206932 no 1755 0.475929679622796 2547 45595294
SGTC_1668 st014914 51.6 µM -0.0608937810691986 0.481430785212328 no 1756 0.475721901122188 2528 2839556
SGTC_975 1335-0046 28.5 µM -0.0611663554414043 0.481331014817695 no 1757 0.47561336200539 2542 16486740
SGTC_158 k038-0087 26.446 µM -0.0612580283622367 0.48129746004189 no 1758 0.475576858253962 2522 X158
SGTC_2317 5986382 200 µM -0.0633247296924785 0.480541026910175 no 1759 0.47475396191596 2551 877883
SGTC_2835 9006588 71.43 µM -0.0634314534886199 0.48050196682412 no 1760 0.474711470706103 2707 2345538
SGTC_1366 1683-0113 21.9 µM -0.063865658408166 0.480343053107471 no 1761 0.474538598526161 2524 708623
SGTC_1037 k284-1091 78.7 µM -0.0655037495059858 0.479743560034072 no 1762 0.473886460537793 2504 3334711
SGTC_1455 4262-0120 131 µM -0.0655660479815545 0.479720761523516 no 1763 0.473861660355307 2707 1529587
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.0657668628675924 0.479647272532007 no 1764 0.473781719348946 2578 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1966 st070145 16.1 µM -0.0658726188145776 0.479608571008294 no 1765 0.47373962012109 2504 3748532
SGTC_1970 st070122 35.8 µM -0.0666415197122358 0.479327196546514 no 1766 0.473433545622382 2597 102928
SGTC_169 k015-0017 16.025 µM -0.0672478795910561 0.479105310209675 no 1767 0.47319218448086 2552 1840002
SGTC_1187 1391-0724 117 µM -0.0672548274914614 0.479102767789653 no 1768 0.473189418930643 2562 6997986
SGTC_1660 st012960 28.1 µM -0.0675188180450711 0.479006167313699 no 1769 0.473084340787614 2569 24207266
SGTC_16 erodoxin 22.806 µM -0.0684467791706639 0.478666613902437 no 1770 0.472714992361767 2537 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2480 5767542 37.17 µM -0.0688658980878319 0.4785132577352 no 1771 0.472548181717138 2571 2867358
SGTC_2723 salbutamol 83.58 µM -0.0690840092519202 0.478433451828274 no 1772 0.472461374692054 2550 9884233 β2-adrenoceptor agonist
SGTC_3202 9113761 49.47 µM -0.0693433813596117 0.478338549851028 no 1773 0.472358147744771 2664 4798415
SGTC_2284 7945075 39.21 µM -0.0694971388407411 0.478282291917981 no 1774 0.472296955011638 2590 1245402
SGTC_824 1304-0008 100 µM -0.0715107406210408 0.477545580649877 no 1775 0.471495638332317 2537 768245
SGTC_2329 6138490 200 µM -0.0715409696733187 0.477534521403107 no 1776 0.47148360949411 2763 720019
SGTC_796 1234-0020 70.7 µM -0.0718794920000552 0.477410674775936 no 1777 0.471348905419634 2526 46495034
SGTC_1300 1094-0077 113 µM -0.0738496416288445 0.476689949487198 no 1778 0.470565013262726 2547 5532636
SGTC_2585 alliin 100 µM -0.074059378117378 0.476613227585696 no 1779 0.470481569011701 2596 87310 A garlic compound which reacts with lipids.
SGTC_1657 st012939 43.4 µM -0.0745428431651364 0.476436378700612 no 1780 0.470289226027998 2603 24207257
SGTC_1705 st027868 56.3335 µM -0.076514317883016 0.475715272390545 no 1781 0.469504961672249 2622 292948
SGTC_527 4476-4215 268 µM -0.076786741600174 0.475615634168187 no 1782 0.46939659913307 2568 4418754
SGTC_974 1326-0144 138 µM -0.0767868885659879 0.475615580416257 no 1783 0.469396540674789 2557 5411856
SGTC_769 0302-0231 76 µM -0.0768910772280956 0.475577474103847 no 1784 0.469355097936832 2593 571869 YER009W NTF2
SGTC_1043 0916-0009 19.3 µM -0.0771921088772473 0.475467375030301 no 1785 0.469235359560505 2523 3101130
SGTC_1128 3448-9350 235 µM -0.0772366273578773 0.475451093035747 no 1786 0.469217652121476 2650 619386
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.0776670825983743 0.475293662335791 no 1787 0.469046439632326 2570 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1169 aniline yellow 25.8 µM -0.0778110532543974 0.475241008705366 no 1788 0.468989176941837 2591 6051 A DNA damaging agent.
SGTC_2261 9010538 184.68 µM -0.0785124212966716 0.474984507263098 no 1789 0.468710224978735 2656 6457250
SGTC_2825 7998094 58.44 µM -0.0800067944612919 0.474438025953683 no 1790 0.468115926048915 2611 2987815
SGTC_5 0352-0601 109.883 µM -0.0811497373566599 0.474020092520309 no 1791 0.467661435696542 2518 762456
SGTC_2002 4023503 131 µM -0.081394162699068 0.473930718589781 no 1792 0.467564245600505 2538 4736863 YCR052W RSC6
SGTC_3206 9114350 49.47 µM -0.0814485441145794 0.473910834247066 no 1793 0.467542622348506 2552 17087243
SGTC_1417 3966-0327 90.4 µM -0.0817737632702676 0.473791920548009 no 1794 0.467413310029934 2572 651118
SGTC_593 1203-0218 61.7 µM -0.0823716578181095 0.47357331144373 no 1795 0.467175586613019 2610 3666956
SGTC_1805 st050013 60.3 µM -0.0830333515593606 0.473331384622144 no 1796 0.466912510230216 2625 4037144
SGTC_2031 5180455 200 µM -0.0841094491710429 0.472937965532199 no 1797 0.466484705957953 2558 29949
SGTC_2849 9019321 12.99 µM -0.084358866232629 0.472846782917889 no 1798 0.466385555327949 2645 16489627
SGTC_1645 Cervolide 78 µM -0.085832239672975 0.472308171960634 no 1799 0.465799888743919 2623 23173 A fragrance.
SGTC_2312 7706453 155.7 µM -0.0861334657325382 0.472198061031607 no 1800 0.465680160331391 2584 976098
SGTC_3070 9117005 49.47 µM -0.0871628523778912 0.471821792544752 no 1801 0.465271033223442 2546 8779016
SGTC_3010 9080089 71.4286 µM -0.0876427342014491 0.471646391414065 no 1802 0.465080317929986 2586 17027233
SGTC_653 0203-0016 55.2 µM -0.0891092251488067 0.471110409983252 no 1803 0.464497552977292 2637 295302
SGTC_3043 9092303 49.47 µM -0.0901866800545081 0.470716648941409 no 1804 0.464069434483741 2590 25236084
SGTC_2786 7743617 45.45 µM -0.0904740959146804 0.470611616263551 no 1805 0.463955238990692 2607 583674
SGTC_264 promethazine 12.5 mM -0.0909183722130373 0.470449264845617 no 1806 0.463778725868963 2553 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_669 0108-0021 26.2 µM -0.0912569894367813 0.470325527608646 no 1807 0.463644196394612 2536 17201
SGTC_223 busulfan 5 mM -0.0925047738116577 0.469869588057528 no 1808 0.463148499266343 2662 2478 A DNA alkylator.
SGTC_2753 fluvastatin 17.09 µM -0.0927743414072705 0.469771093412061 no 1809 0.463041417833729 2642 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2395 5646831 180.19 µM -0.0948324211495434 0.469019173355574 no 1810 0.462223967278702 2676 6808628
SGTC_3090 9117696 49.47 µM -0.0964279216617077 0.468436332649265 no 1811 0.461590358583699 2688 7923821
SGTC_338 4055-0136 114 µM -0.0971886826842573 0.468158448304691 no 1812 0.461288277703439 2565 2900563
SGTC_2918 7977171 22.06 µM -0.0992116220002726 0.467419601998568 no 1813 0.460485123682333 2568 2236483
SGTC_6 0844-0013 19.835 µM -0.0992567857023885 0.467403107948398 no 1814 0.460467194468023 2615 1584900
SGTC_991 3996-0057 64.7 µM -0.100673495145018 0.466885745869609 no 1815 0.45990482613225 2658 715343
SGTC_2110 5483698 200 µM -0.102976732587029 0.466044756203575 no 1816 0.45899071873517 2647 2848765 YHR062C RPP1
SGTC_1978 st071761 42 µM -0.103352090062048 0.465907714797883 no 1817 0.458841767517862 2611 5147680
SGTC_725 1497-0963 19 µM -0.103860023961184 0.465722276747191 no 1818 0.458640215869504 2627 3549977
SGTC_1390 3413-2614 145 µM -0.104588958289564 0.46545616820283 no 1819 0.458350988328903 2625 3421432
SGTC_2334 9017922 200 µM -0.105210622043753 0.465229232609492 no 1820 0.458104341165694 2709 3163164
SGTC_1819 st053448 58.6 µM -0.108010070239919 0.464207447650822 no 1821 0.456993852024525 2612 2857616
SGTC_302 1094-0063 18.9 µM -0.108209210714161 0.464134771259921 no 1822 0.456914869383506 2599 5440289
SGTC_880 0833-0487 87.2 µM -0.109088015509567 0.463814065445259 no 1823 0.456566340198375 2597 76075
SGTC_2646 retinol 96.75 µM -0.109819032091252 0.463547310490217 no 1824 0.456276448456062 2673 445354 A vitamin A analog and teratogen.
SGTC_2865 9030313 51.95 µM -0.110383673993246 0.463341278461633 no 1825 0.456052550134292 2601 42562754
SGTC_2160 5660466 132.927 µM -0.110946377251337 0.463135963605995 no 1826 0.455829434428637 2576 2859134
SGTC_545 4218-0007 221 µM -0.110965335548041 0.463129046418557 no 1827 0.455821917575968 2680 2840508
SGTC_1249 0481-0015 10.2 µM -0.111328887496244 0.462996401799942 no 1828 0.455677774438068 2614 4227577
SGTC_2872 9044037 25.97 µM -0.112097746510373 0.462715891468083 no 1829 0.455372952094761 2594 6465195
SGTC_1607 st000305 50.6 µM -0.113522455822054 0.46219614998818 no 1830 0.454808180493464 2744 5457690
SGTC_1298 1079-1278 263 µM -0.114928415674678 0.461683311679899 no 1831 0.454250930936034 2638 2840950
SGTC_93 0109-0045 59.227 µM -0.114947356558811 0.461676403230687 no 1832 0.454243424364246 2577 88733
SGTC_780 0109-0199 192 µM -0.115599803947994 0.461438438326854 no 1833 0.453984859146154 2787 610414
SGTC_2378 9074213 121.43 µM -0.116199391817747 0.461219764865635 no 1834 0.453747259373872 2621 657714
SGTC_2760 etidronate 98.04 µM -0.118674794863529 0.460317094680087 no 1835 0.452766503094121 2655 3305 A chelator and antioxidant.
SGTC_702 1488-0190 94 µM -0.118888095896025 0.460239322714544 no 1836 0.452682006484132 2682 949357
SGTC_247 mechlorethamine 29.705 µM -0.119788949185702 0.459910878243591 no 1837 0.452325168088574 2611 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_925 2064-1272 59.6 µM -0.119833911508017 0.45989448602707 no 1838 0.452307358999761 2655 6815817
SGTC_1049 3226-0134 66 µM -0.121709572909844 0.459210724596209 no 1839 0.451564515760223 2587 5702385
SGTC_1347 1493-0251 600 nM -0.122320772927948 0.458987941155823 no 1840 0.451322490556651 2714 3986378
SGTC_539 4859-0462 2.54 µM -0.123128997597439 0.458693361684744 no 1841 0.451002474613331 2784 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1434 4073-0095 163 µM -0.123672259165247 0.458495367962487 no 1842 0.450787388492536 2642 24133745
SGTC_2845 9003024 42.97 µM -0.123929608228549 0.458401579719335 no 1843 0.450685504838576 2834 2990173
SGTC_1717 st033143 58.0435 µM -0.123946151138795 0.458395550903467 no 1844 0.4506789556655 2709 674616
SGTC_354 2783-3500 4.88 µM -0.125417915836892 0.457859226765992 no 1845 0.45009635265732 2654 6740761
SGTC_3172 9105863 49.47 µM -0.125787208215508 0.457724665343462 no 1846 0.449950183853603 2649 2348785
SGTC_803 4488-1585 147 µM -0.127318839190501 0.457166627079891 no 1847 0.449344025064449 2732 747204
SGTC_1969 st069479 40.1 µM -0.127439032223126 0.457122839208695 no 1848 0.449296462412747 2741 3895485
SGTC_934 2950-0684 338 µM -0.128683165265144 0.456669616181625 no 1849 0.448804178407989 2850 1121253
SGTC_1911 st060208 74.3 µM -0.130407495598557 0.456041556244171 no 1850 0.448122018301701 2742 688783
SGTC_310 1273-0058 1.06 µM -0.1308573616401 0.455877717683372 no 1851 0.447944072521942 2673 2734232
SGTC_984 1492-0255 2.91 µM -0.130924281809305 0.455853346392536 no 1852 0.447917602954688 2776 1585198
SGTC_185 k048-0037 25.491 µM -0.131627693226953 0.455597184897803 no 1853 0.447639390038511 2619 6827589
SGTC_3239 9133757 49.47 µM -0.132688860834678 0.455210774211664 no 1854 0.447219726364969 2625 17036923
SGTC_1922 5578187 25 µM -0.132891947448495 0.455136827623829 no 1855 0.447139417711733 2865 1350412
SGTC_2516 gossypol 71.55 µM -0.133627764620046 0.454868919659055 no 1856 0.446848464046156 2759 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1333 1482-0047 286 µM -0.133875919206072 0.454778572231337 no 1857 0.446750346268548 2627 3811116
SGTC_843 0310-0051 143 µM -0.134715060906289 0.454473077224618 no 1858 0.44641858243115 2659 2065037
SGTC_1523 st012844 44.7 µM -0.135636490056217 0.454137655960492 no 1859 0.446054328559 2775 4274103
SGTC_574 1315-0397 40 µM -0.135923622891704 0.454033139720292 no 1860 0.445940830208741 2641 6794277
SGTC_1882 5615643 20 µM -0.137016888427599 0.453635220685 no 1861 0.44550872298804 2620 2253075
SGTC_1721 st082152 9.2685 µM -0.138460869768868 0.453109721994145 no 1862 0.444938096545145 2641 5296051
SGTC_2097 5376186 200 µM -0.138518861489772 0.453088619154999 no 1863 0.444915181996919 2704 742755
SGTC_736 0958-0254 92.6 µM -0.138785505285454 0.452991590784169 no 1864 0.444809824118679 2753 6812352
SGTC_2718 lomofungin 53.02 µM -0.139079712346771 0.452884535739751 no 1865 0.444693579803917 2765 5351222 A RNA synthesis inhibitor.
SGTC_1884 5633444 25 µM -0.140229595831647 0.452466153047885 no 1866 0.444239294419634 2792 5724239
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.140460932812536 0.452381987934655 no 1867 0.444147908765677 2673 689007
SGTC_755 1995-0008 37.3 µM -0.140707567761825 0.452292259465108 no 1868 0.444050483185736 2645 689533
SGTC_2591 skatole 100 µM -0.140776668767559 0.452267120206524 no 1869 0.44402318755672 2771 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2696 st077691 74.316 µM -0.141473259535166 0.452013708037886 no 1870 0.44374804167842 2797 757133
SGTC_377 3970-0964 33.1 µM -0.143583910888789 0.451245995736125 no 1871 0.442914523123514 2661 16481235
SGTC_1469 k284-2957 126 µM -0.145541898880381 0.450533974999624 no 1872 0.442141518690231 2696 23884841
SGTC_1253 0550-0034 176 µM -0.146993322836378 0.45000626845945 no 1873 0.441568645338262 2766 5969915
SGTC_325 2810-4341 181 µM -0.147036811372998 0.449990458321867 no 1874 0.441551482403049 2781 774970
SGTC_2091 4-phenylthiadiazole 200 µM -0.148825008207258 0.449340433312901 no 1875 0.440845858348244 2698 270010
SGTC_2793 7325131 81.82 µM -0.149933721975945 0.448937474427853 no 1876 0.440408453070286 2751 4176441
SGTC_1707 st032323 6.317 µM -0.150401380233096 0.448767521124411 no 1877 0.440223976194599 2674 3132057 YMR211W DML1
SGTC_3095 9117207 49.47 µM -0.150453930050981 0.448748424400431 no 1878 0.440203247709237 2806 17015229
SGTC_751 0833-0568 350 µM -0.151110344497978 0.448509891908987 no 1879 0.439944336238562 2739 6954252
SGTC_2743 auranofin 4.32 µM -0.151167749142699 0.448489032689868 no 1880 0.439921695176129 2715 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2295 7971645 200 µM -0.153520064771135 0.447634391066885 no 1881 0.43899408423132 2765 2978226 YKL099C UTP11
SGTC_1460 k062-0059 9.15 µM -0.153985311819611 0.447465386508293 no 1882 0.438810658460867 2600 1373085
SGTC_1066 ketoconazole 628 nM -0.154613108739824 0.447237349586105 no 1883 0.438563167498332 2842 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_508 roscovitine 141 µM -0.154986079103598 0.447101882480023 no 1884 0.438416145978894 2678 160355 A CDKinase inhibitor.
SGTC_2025 5147754 141 µM -0.155492792063744 0.446917848422506 no 1885 0.438216417966117 2770 315777 YLR208W SEC13
SGTC_1636 st007707 68.9 µM -0.155766737483369 0.44681835841476 no 1886 0.43810844509092 2799 403051
SGTC_1583 clindamycin 39.6 µM -0.156502607087269 0.446551125881843 no 1887 0.437818432203533 2678 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_3277 9138724 49.47 µM -0.156592260359251 0.446518569771273 no 1888 0.437783101314892 2756 15943418
SGTC_1988 st071872 53.4 µM -0.156892628030363 0.44640949882195 no 1889 0.437664734943009 2688 16414116
SGTC_3247 9135149 49.47 µM -0.15710779229223 0.446331369835137 no 1890 0.437579948244183 2653 8934436 YOR116C RPO31
SGTC_313 3474-0040 5.03 µM -0.157382202630305 0.446231730838494 no 1891 0.437471819451718 2670 1043375 YIL048W NEO1
SGTC_1141 3253-0389 52.6 µM -0.16035272715369 0.445153345453921 no 1892 0.436301612965566 2669 5402031
SGTC_3304 9125678 46.087 µM -0.160685604212706 0.445032526692684 no 1893 0.436170514132361 2723 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1747 st037496 66.6 µM -0.160927780694309 0.444944631195309 no 1894 0.436075140820308 2707 723305
SGTC_3003 9075612 71.4286 µM -0.161049395614024 0.444900493314507 no 1895 0.436027248150552 2783 6501993
SGTC_1273 0849-0096 14.1 µM -0.161871505215057 0.444602141818264 no 1896 0.435703521197952 2737 5286025
SGTC_510 ag-490 170 µM -0.162020608841001 0.444548034032865 no 1897 0.43564481239131 2743 5328779
SGTC_1113 artemisinin 1.17947 µM -0.163404091412032 0.444046035433256 no 1898 0.435100140850196 2729 2240 An anti-malaria and mitochondrial poison.
SGTC_916 4466-0038 42 nM -0.163920393700691 0.443858717376599 no 1899 0.434896906201613 2772 5722064 YGL116W CDC20
SGTC_456 gingerol 170 µM -0.164053725440838 0.443810345731105 no 1900 0.434844424955038 2857 442793 A herb.
SGTC_1756 st041558 35.5 µM -0.165490644606688 0.443289096689914 no 1901 0.434278906415639 2831 3955792
SGTC_873 0591-4978 488 µM -0.166349832099063 0.44297746928917 no 1902 0.433940825980657 2915 3305145
SGTC_2019 4016004 108 µM -0.166537873120595 0.442909271487024 no 1903 0.43386684042902 2773 45595336
SGTC_1464 k208-0027 110 µM -0.167268799113375 0.442644198889973 no 1904 0.433579276471364 2884 X1464
SGTC_73 0327-0325 16.231 µM -0.167698108510315 0.442488520454767 no 1905 0.433410392153703 2880 53298
SGTC_818 4072-2707 53.5 µM -0.169594098850032 0.441801092982636 no 1906 0.432664681877666 2694 882871
SGTC_364 0083-0097 67.7 µM -0.169894666683718 0.441692132419858 no 1907 0.432546487758562 2840 5207356
SGTC_628 1636-0253 16 µM -0.170038286577285 0.441640069508958 no 1908 0.432490013363766 2800 4456143
SGTC_2017 5132927 60.65 µM -0.170309478054581 0.441541764027822 no 1909 0.432383378872378 2725 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2951 9072950 58.06 µM -0.170725310244369 0.441391034046941 no 1910 0.432219880152978 2708 16488155
SGTC_849 0386-0493 241 µM -0.171266258661651 0.441194964904485 no 1911 0.432007205062748 2717 726119
SGTC_2136 5328288 199.296 µM -0.171296776246635 0.441183904100062 no 1912 0.431995207591935 2745 262395
SGTC_2429 5902844 64.44 µM -0.17259547611416 0.440713245481063 no 1913 0.431484704035295 2861 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2288 7946289 167.31 µM -0.173038559580409 0.44055268781864 no 1914 0.431310559300656 2852 1246052
SGTC_488 nitrendipine 139 µM -0.176341499722676 0.439356129705557 no 1915 0.43001283038741 2701 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_852 0418-0143 439 µM -0.177037858915635 0.439103929570802 no 1916 0.429739326062516 2799 5369229
SGTC_449 xestospongin c 11.1929 µM -0.177163738476486 0.439058342454844 no 1917 0.429689888787073 2847 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_263 alizarin 107.927 µM -0.179121505315466 0.438349444208099 no 1918 0.428921148141968 2695 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2970 9090938 41.86 µM -0.180747837155451 0.437760707305949 no 1919 0.428282754255269 2952 17217104
SGTC_3076 9116187 49.47 µM -0.181030721943141 0.437658316209868 no 1920 0.428171730887238 2838 27241210
SGTC_229 benomyl 22.8748 µM -0.182248212308391 0.437217689224243 no 1921 0.427693969269499 2797 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2361 9034121 116 µM -0.18328100882165 0.436843966573186 no 1922 0.427288767379827 2778 6496917
SGTC_3223 9129970 49.47 µM -0.187074613290312 0.435471717761501 no 1923 0.425801066207585 2737 17248386
SGTC_1384 3089-0840 101 µM -0.188563571065218 0.434933332991006 no 1924 0.425217443312743 2822 1069836
SGTC_1230 0170-0365 3.77 µM -0.189108413990813 0.4347363560622 no 1925 0.425003923531187 2833 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1815 st051655 58.2 µM -0.189442933434478 0.4346154253526 no 1926 0.424872838811754 2793 5984156
SGTC_540 1187-0821 17.3 µM -0.192634425403606 0.433461991753003 no 1927 0.423622641136837 2748 847520
SGTC_113 0099-0221 2.5 µM -0.193011084313537 0.433325901054044 no 1928 0.423475143643187 2883 89219
SGTC_2522 biochanin a 4.94 µM -0.193596836321943 0.433114278602001 no 1929 0.423245787788354 2875 5280373 A possible chelator.
SGTC_1276 0871-0068 94.2 µM -0.19515920324896 0.43254991539314 no 1930 0.422634158003405 2846 3414906
SGTC_3275 9138069 49.47 µM -0.196120709300229 0.432202665394624 no 1931 0.422257843668177 2834 17617007
SGTC_2193 5925765 200 µM -0.196855370571954 0.43193737615864 no 1932 0.421970359667622 2878 877370
SGTC_878 0828-0289 13.7 µM -0.197330410239667 0.43176585369218 no 1933 0.421784491626507 2785 745350 YLR208W SEC13
SGTC_67 0335-0847 266 µM -0.198270591890929 0.431426420465965 no 1934 0.421416679598242 3141 4552207 YOR254C SEC63
SGTC_2546 rhodinyl acetate 100 µM -0.200743666847329 0.430533810063488 no 1935 0.420449506725467 2769 6708682
SGTC_654 1124-0271 80.9 µM -0.201170632964935 0.430379740374788 no 1936 0.420282576780754 2789 5403748
SGTC_2948 9070189 9.45 µM -0.201456389376225 0.43027663178497 no 1937 0.420170863271866 2908 6473636 YDL196W YDL196W
SGTC_1508 1080-0625 72.9 µM -0.201712496577423 0.430184225466144 no 1938 0.420070746278896 2731 767111
SGTC_828 2074-0507 139 µM -0.202473864680216 0.42990953800881 no 1939 0.4197731441171 2905 X828
SGTC_3153 9100258 49.47 µM -0.202683754738019 0.429833819537169 no 1940 0.419691110737123 2792 25236848
SGTC_1802 st050112 57.9 µM -0.203151051303196 0.429665250164257 no 1941 0.419508485198179 2732 4662563
SGTC_2955 9076254 12.21 µM -0.203274471777611 0.429620730444115 no 1942 0.419460253773652 2852 16459619
SGTC_1075 aripiprazole 15.2 µM -0.203281328324527 0.429618257205269 no 1943 0.419457574342636 2759 60795 An atypical antipschotic. YIL048W NEO1
SGTC_3224 9130643 49.47 µM -0.203333266059398 0.429599522730048 no 1944 0.419437278011593 2966 17644395
SGTC_1844 rapamycin 4 nM -0.20373438806688 0.429454839239402 no 1945 0.419280533981998 2741 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_290 2043-6722 48.1 µM -0.204847878454096 0.429053256355197 no 1946 0.418845489258935 2846 773758 YLR208W SEC13
SGTC_3314 9135860 59.4275 µM -0.208224542511174 0.427835905265242 no 1947 0.417526823198152 2807 25252478
SGTC_1743 st037606 46.3785 µM -0.20827813712322 0.427816588901476 no 1948 0.417505900686373 2791 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_3177 9107506 49.47 µM -0.210547088247044 0.426998981537079 no 1949 0.416620352047178 2890 8897194
SGTC_1470 k295-0292 231 µM -0.212524564091425 0.426286661664812 no 1950 0.415848908039992 2887 5045612
SGTC_1999 st074831 12.5 µM -0.21273440349762 0.426211088069598 no 1951 0.415767065404663 2809 17112523
SGTC_2856 9022925 19.48 µM -0.216090691085586 0.425002692271256 no 1952 0.414458527870571 2938 4944862
SGTC_1388 3346-4487 254 µM -0.216345204621795 0.424911085957104 no 1953 0.414359337554847 2873 3345614
SGTC_155 k072-0202 43.6 µM -0.217593228638765 0.424461947095741 no 1954 0.413873030425554 2752 5857737
SGTC_2808 7946468 45.46 µM -0.217919993990955 0.424344366962641 no 1955 0.413745724274012 2867 2970879
SGTC_1303 1160-0052 261 µM -0.218035037134947 0.424302972535014 no 1956 0.413700906195745 2813 3562476
SGTC_1234 0326-0494 15.5 µM -0.21839515743709 0.424173400688738 no 1957 0.413560619143652 2938 1547813
SGTC_3234 9132280 49.47 µM -0.219415138841554 0.423806454313093 no 1958 0.413163339124973 2867 17612295
SGTC_1936 st074407 74.3 µM -0.219419750338948 0.423804795440206 no 1959 0.413161543160699 2790 809813
SGTC_1949 st076024 69.1 µM -0.219810081518253 0.423664388285548 no 1960 0.413009533867022 2729 2921930
SGTC_1241 0364-0022 50.8 µM -0.219835536330129 0.423655232198147 no 1961 0.412999621281348 2856 4563895
SGTC_1336 1486-0901 104 µM -0.220289131045668 0.423492081245426 no 1962 0.412822992218118 2875 5006114
SGTC_1850 st056238 17 µM -0.221025217284798 0.423227350417055 no 1963 0.41253639897599 2750 5393177
SGTC_1422 4031-0024 15.5 µM -0.221478665149032 0.4230642867299 no 1964 0.412359873439646 2826 782427
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.221668030752771 0.422996193156697 no 1965 0.412286159372678 2735 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1114 scopoletin 1.73284 µM -0.221920886563237 0.422905272862565 no 1966 0.412187735391997 2918 5280460 A coumarin with genotoxic properties.
SGTC_1519 esterone 74 µM -0.221979778726036 0.422884097380293 no 1967 0.412164812443789 2791 698 A steroid.
SGTC_739 1486-1183 203 µM -0.222911819613555 0.422548999042778 no 1968 0.411802068553067 2889 4346692
SGTC_1468 k284-1086 134 µM -0.223452502050649 0.422354632183507 no 1969 0.411591673192342 2833 15996457
SGTC_811 0416-0114 265 µM -0.226261578779007 0.42134511844924 no 1970 0.410498989609315 2888 6612453
SGTC_635 k038-0028 24.7 µM -0.22938314459949 0.420223910235538 no 1971 0.409285567801215 2855 4035102
SGTC_3283 9109332 35.8195 µM -0.231893632200243 0.419322658909975 no 1972 0.40831031525271 2787 17027281
SGTC_2879 9041815 71.43 µM -0.233027844052695 0.418915621527504 no 1973 0.407869892219436 2904 4942971
SGTC_2622 2-methoxyxanthone 59.94 µM -0.234354136493753 0.41843976181173 no 1974 0.40735503050536 2885 71034 A hepatoprotective.
SGTC_754 3474-0146 171 µM -0.236184802661595 0.417783134310568 no 1975 0.406644635842371 2802 24762078
SGTC_36 0335-0881 14.2 µM -0.237575084252404 0.41728461793949 no 1976 0.406105338580092 2800 23828853
SGTC_3061 glucosamine 200 µM -0.239124457255744 0.416729212459893 no 1977 0.405504538832731 2865 91431 and experimental redox chemotherapeutic
SGTC_2242 6630449 61.2675 µM -0.240927471286928 0.416083093272126 no 1978 0.40480566508138 3001 691249 YDR170C SEC7
SGTC_2601 securinine 100 µM -0.241866447455624 0.415746696092658 no 1979 0.404441824690224 2841 442872 A GABA receptor antagonist.
SGTC_2729 fluphenazine 10.66 µM -0.242408032743842 0.415552696046 no 1980 0.404232005367702 2826 3372 An atypical antipsychotic.
SGTC_8 0354-0001 70 µM -0.242503845638019 0.415518377266269 no 1981 0.404194888693952 2843 4993152
SGTC_4 0960-0234 25.671 µM -0.245033619532482 0.414612483102009 no 1982 0.403215200034805 2897 6821112
SGTC_1326 1431-2094 10.8 µM -0.245633619116797 0.414397693909697 no 1983 0.402982931048746 2794 616278
SGTC_1270 0831-1170 17.3 µM -0.247669069266216 0.413669229984771 no 1984 0.4021952327563 2823 6764716
SGTC_2978 9011784 42.97 µM -0.247778510290636 0.413630070707484 no 1985 0.402152891423543 2972 2994934
SGTC_1406 3909-7906 11.9 µM -0.250378713237817 0.412699941194895 no 1986 0.401147244918055 2891 X1406
SGTC_1309 pyrazolanthrone 13.4 µM -0.251247842708206 0.412389150242567 no 1987 0.400811248705059 2944 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_3205 9113483 49.47 µM -0.251279118317622 0.412377967458051 no 1988 0.400799159253018 3047 17018033
SGTC_2393 9031399 185.94 µM -0.25352974668583 0.411573428869411 no 1989 0.399929438661074 3021 1526623 YDL150W RPC53
SGTC_2386 9075165 157.42 µM -0.253668419402224 0.411523869256004 no 1990 0.399875866914279 2832 16452277
SGTC_278 4092-0821 23.9 µM -0.254961518331238 0.411061802547543 no 1991 0.399376410549234 2927 877900
SGTC_2182 6325192 200 µM -0.256379422675611 0.410555280585538 no 1992 0.398828937661444 2859 736248
SGTC_2619 obliquin 87.91 µM -0.256805363541591 0.410403149623568 no 1993 0.398664514697535 2857 6708593 A bioactive alkalod. YER133W GLC7
SGTC_988 1497-1057 103 µM -0.257069099247844 0.410308959344746 no 1994 0.398562715666814 2873 3533044
SGTC_1015 4130-4525 82 µM -0.257792660039978 0.410050574225487 no 1995 0.398283464760035 2892 1363237
SGTC_381 3461-2219 42.7 µM -0.260692947201263 0.409015268472236 no 1996 0.397164652682382 2985 2883159
SGTC_1146 3579-1023 7 µM -0.261043737881765 0.408890090767444 no 1997 0.397029389144268 2972 X1146
SGTC_1794 st048918 76.9 µM -0.262415190461443 0.408400784831857 no 1998 0.3965006813149 2927 672303
SGTC_2708 st078559 56 µM -0.263642762008499 0.40796293373971 no 1999 0.39602760229674 2956 17250902
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.264139901445643 0.407785646353116 no 2000 0.395836059228241 2968 140250 A respiratory chain inhibitor.
SGTC_2990 9074105 71.4286 µM -0.264214532788254 0.40775903332506 no 2001 0.395807306656164 2924 6502001
SGTC_3138 9097216 49.47 µM -0.264523073005575 0.407649014505165 no 2002 0.395688444053086 2812 25237486
SGTC_1286 0929-0070 131 µM -0.265252334058984 0.407389004629745 no 2003 0.395407540758053 2974 1420408
SGTC_2190 6049624 200 µM -0.265351520658395 0.407353643905929 no 2004 0.395369339370869 2929 2265554
SGTC_1000 4048-0884 8.67 µM -0.266373573936867 0.406989318708436 no 2005 0.394975757588175 3011 13040088
SGTC_1594 piperine 70.1 µM -0.267276268020098 0.406667607675701 no 2006 0.394628228842208 2854 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_288 1315-0019 35.1 µM -0.268172202168425 0.406348368086888 no 2007 0.394283385505355 2963 6811474
SGTC_1152 3909-8331 15.9 µM -0.270279618617706 0.405597698427632 no 2008 0.393472572021811 2900 16001939
SGTC_1476 4112-3294 3.34 µM -0.271434114347162 0.405186609670147 no 2009 0.393028583538317 3014 704369
SGTC_2681 menadione 3.18 µM -0.272136548104353 0.404936540687645 no 2010 0.392758514151129 2969 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2721 ifenprodil 61.44 µM -0.273180145428442 0.404565087928107 no 2011 0.392357370687934 3029 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2594 a-mangostin 100 µM -0.275072737229777 0.403891667974698 no 2012 0.391630178232529 3060 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1571 st070080 73.4 µM -0.275159626209458 0.403860758054272 no 2013 0.391596801860749 3037 4315245
SGTC_137 0438-0332 85.389 µM -0.275570820919748 0.403714487629593 no 2014 0.391438861846058 2947 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1903 st060211 78.3 µM -0.275930801867079 0.403586446047845 no 2015 0.39130060774379 3056 688960
SGTC_2222 6885208 172.143 µM -0.275970713675971 0.403572250457206 no 2016 0.391285280079815 2929 609514
SGTC_2158 5657123 3.6195 µM -0.276563789423944 0.403361323843266 no 2017 0.391057536172569 2861 2858827
SGTC_862 0452-0056 10.2 µM -0.276749534071493 0.403295269779898 no 2018 0.390986217022266 2960 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1653 st012112 65 µM -0.27676553295096 0.403289580426015 no 2019 0.390980074209226 3063 720429
SGTC_548 1436-0017 110 µM -0.278212182835384 0.402775222702 no 2020 0.390424741677319 3033 9677137
SGTC_844 0330-0132 15.3 µM -0.279301949168327 0.402387866302089 no 2021 0.390006555284475 3020 2828079
SGTC_1462 k081-0014 26.5 µM -0.279668840659061 0.402257476615658 no 2022 0.389865793138579 2914 3270634
SGTC_369 0957-0393 4.5 µM -0.279797135024926 0.402211884604736 no 2023 0.389816574934788 2962 6997992
SGTC_1552 6-methylflavone 10.6 µM -0.281865976792543 0.401476863738414 no 2024 0.389023139381614 2926 689013
SGTC_1606 st000094 49.2 µM -0.282777263599987 0.401153210938719 no 2025 0.388673792149817 3048 1242210
SGTC_667 1498-1044 59 µM -0.283973415078084 0.400728488510438 no 2026 0.388215377006089 2940 6739982
SGTC_253 dyclonine 31.25 µM -0.285045841233781 0.400347797475071 no 2027 0.387804510912756 2917 3180 An oral anasthetic.
SGTC_2362 9071156 126 µM -0.285628878498824 0.400140869951002 no 2028 0.387581191329775 3077 653133
SGTC_171 k064-0041 9.68 µM -0.285943039344559 0.400029381790662 no 2029 0.387460874350012 2935 53325
SGTC_1548 st061468 90.8 µM -0.28657043346279 0.399806759034885 no 2030 0.387220627986121 3031 390799
SGTC_3160 9100216 49.47 µM -0.286666330784999 0.399772733967436 no 2031 0.38718391008237 2879 17191039
SGTC_2818 7996756 12.99 µM -0.286922139277238 0.399681974977062 no 2032 0.387085969099171 2853 2241621
SGTC_2600 tangeritin 87.95 µM -0.287823548630335 0.39936220473263 no 2033 0.386740905292637 2889 68077 A bioactive flavone.
SGTC_221 trifluoperazine 10.304 µM -0.288421733791852 0.399150038930576 no 2034 0.386511966550634 2938 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2457 5731572 11.68 µM -0.289829849892457 0.398650722502406 no 2035 0.385973205301929 3044 2865357
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.290153496362047 0.398535981229192 no 2036 0.385849405513116 2898 15053
SGTC_2177 5811945 192 µM -0.294511057591953 0.3969919677994 no 2037 0.384183707582627 3088 5343475
SGTC_373 0844-0104 25.9 µM -0.295029345840769 0.396808429752937 no 2038 0.383985731095244 3060 5375804
SGTC_2934 9036370 36.88 µM -0.295185968542903 0.396752970469599 no 2039 0.383925910084878 3020 6462800
SGTC_2812 7970281 58.44 µM -0.295489275325732 0.39664557705596 no 2040 0.383810071920108 3073 2233435
SGTC_2612 dictamnine 15.46 µM -0.295741173815656 0.396556392003257 no 2041 0.383713875372201 3012 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2449 5812982 45.77 µM -0.297550000346912 0.395916133374895 no 2042 0.383023320367417 3001 776185
SGTC_1501 4491-0275 38.4 µM -0.298083421284031 0.395727375335027 no 2043 0.382819747314565 3037 5104718
SGTC_2935 9038016 29.96 µM -0.298448061235937 0.395598356743159 no 2044 0.382680605916389 3080 6463195
SGTC_1475 4092-1048 11.7 µM -0.301676607812234 0.394456518078697 no 2045 0.381449301105621 3007 2881759
SGTC_2683 piperine 63.03 µM -0.303149437605541 0.393935923424636 no 2046 0.380887989933779 2952 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2196 6573537 42.6665 µM -0.304341377211688 0.393514752454874 no 2047 0.380433912402521 3061 2903087
SGTC_1714 st033236 13.627 µM -0.304671742741303 0.393398040067401 no 2048 0.380308086522445 3131 2916566
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.304958142000844 0.393296867948232 no 2049 0.380199016264942 2926 803109
SGTC_2181 6316240 54.2555 µM -0.305638022942535 0.393056725118984 no 2050 0.379940133403533 3020 12779990
SGTC_348 k064-0012 10.7 µM -0.305871480698339 0.392974274170883 no 2051 0.37985125051678 2895 5066323
SGTC_481 bay k-8644 50 µM -0.306068913379114 0.39290455004931 no 2052 0.379776088180813 2949 2303 A calcium channel antagonist.
SGTC_244 nsc-207895 1.295 µM -0.306235641377085 0.392845672082183 no 2053 0.379712618610259 2880 42640
SGTC_1115 galangin 695.678 nM -0.309103679025828 0.391833244320367 no 2054 0.378621330341354 3112 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_401 neomycin 50 µM -0.309836143317836 0.391574798829173 no 2055 0.378342782389038 3002 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2470 5664817 21.68 µM -0.310840960502802 0.391220333171362 no 2056 0.377960764545321 2925 2859561
SGTC_3022 9087993 49.47 µM -0.311582264182964 0.390958884086903 no 2057 0.377679007409775 3027 17173644
SGTC_1319 1306-0155 43.7 µM -0.311950985998985 0.390828858584225 no 2058 0.377538886635933 2940 3122360
SGTC_3125 9127534 49.47 µM -0.312359065813384 0.390684968165195 no 2059 0.377383827919755 3026 1639235
SGTC_385 1494-0393 12.4 µM -0.312848253422787 0.390512498571319 no 2060 0.377197976597937 3001 3090647
SGTC_3190 9110366 49.47 µM -0.313301945634359 0.390352562603973 no 2061 0.377025636046392 3059 17123768
SGTC_375 3970-0961 9.27 µM -0.313492593417554 0.390285360818915 no 2062 0.376953223454909 2993 2898222
SGTC_232 clozapine 119 µM -0.315058031494179 0.389733680835754 no 2063 0.37635879648023 2934 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1863 st057641 20.1 µM -0.31523717265401 0.389670563388246 no 2064 0.37629079179811 2986 3921635
SGTC_2987 9018338 71.43 µM -0.31615853314621 0.389345983142207 no 2065 0.375941090190435 3051 5055682
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.316557847155752 0.389205335303247 no 2066 0.375789562511533 2985 4330530
SGTC_2976 9009005 19.48 µM -0.317336720418964 0.388931039500842 no 2067 0.37549405862336 3162 2993148
SGTC_1461 k072-0203 53.8 µM -0.318384653380867 0.388562076302748 no 2068 0.375096588959954 3012 5418714
SGTC_1306 1185-0270 9.02 µM -0.318837064974177 0.388402819269406 no 2069 0.374925035079417 3081 1548076
SGTC_537 1334-0398 209 µM -0.319077749282083 0.388318101698944 no 2070 0.374833777988334 3132 5846986
SGTC_499 genistein 192 µM -0.319576932172428 0.38814241311967 no 2071 0.374644531748277 3032 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_3199 9111318 49.47 µM -0.320811586646226 0.387707971994493 no 2072 0.374176589138588 3084 8548020
SGTC_282 k297-0036 65.7 µM -0.321009995401362 0.387638170475874 no 2073 0.374101408109978 3104 5061378
SGTC_3056 9094900 49.47 µM -0.321347222156625 0.387519540194654 no 2074 0.373973637163335 3008 25236784
SGTC_464 bw-b 70c 158 µM -0.322266290876897 0.387196281758194 no 2075 0.373625483989455 3091 5353454
SGTC_1994 st072947 40.9 µM -0.322841748757219 0.386993919268473 no 2076 0.373407546790283 3089 5286565 YDL195W SEC31
SGTC_1886 st057356 49.9 µM -0.322914517710894 0.386968331907542 no 2077 0.373379990640704 2958 24207747
SGTC_411 enrofloxacin 100 µM -0.323466579772104 0.386774229262172 no 2078 0.373170956861956 3140 71188 A bacterial gyrase inhibitor.
SGTC_615 k087-0205 167 µM -0.324358094196615 0.386460836435728 no 2079 0.372833471055884 2989 9642773
SGTC_2357 9067248 200 µM -0.324886717944921 0.386275045019519 no 2080 0.37263340481201 3065 9150235
SGTC_2791 5663188 71.43 µM -0.326846386036587 0.385586522997257 no 2081 0.371892036747051 3154 54690634
SGTC_1500 4488-1866 171 µM -0.328298552833104 0.38507654198588 no 2082 0.371342969134688 3112 2900003
SGTC_2956 9076196 2.52 µM -0.328680301863021 0.384942509925806 no 2083 0.371198672345818 3110 16423868
SGTC_823 0417-1665 178 µM -0.328682093974552 0.384941880747969 no 2084 0.371197994990734 3072 3429856
SGTC_657 3534-0529 86.7 µM -0.32934121156539 0.384710497081812 no 2085 0.370948898814031 3140 1049549
SGTC_2152 5568786 200 µM -0.329938088788946 0.384500998361294 no 2086 0.370723371395692 3007 5399883
SGTC_677 0929-0063 136 µM -0.330595300027994 0.384270361941621 no 2087 0.370475098409025 3017 1539583
SGTC_2309 7664088 163.95 µM -0.332373237965627 0.383646632263957 no 2088 0.369803721998611 3172 704922
SGTC_2343 7990716 14.84 µM -0.333806372629872 0.38314408448408 no 2089 0.369262837165394 2961 6456862
SGTC_2659 sanguinarine 24.21 µM -0.334128318268818 0.383031216966267 no 2090 0.369141365980026 2975 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_819 1013-0258 27.7 µM -0.335198947200225 0.382655947955955 no 2091 0.368737508076565 3008 5753198
SGTC_2925 9010536 32.5 µM -0.336309998307148 0.38226662692545 no 2092 0.368318555522418 3043 2994177
SGTC_3000 9075062 71.4286 µM -0.336615523781989 0.382159589243637 no 2093 0.3682033761088 3013 17057871
SGTC_2931 9014674 55.67 µM -0.337696387094666 0.381780992324365 no 2094 0.367795998834934 2972 2996810
SGTC_443 clozapine 122 µM -0.338012784948757 0.381670188165108 no 2095 0.367676776625735 3064 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1498 4478-3555 97.6 µM -0.338903021266819 0.381358474862228 no 2096 0.367341394178276 3067 3437919
SGTC_1735 st034310 56.75 µM -0.339950718753881 0.380991725627162 no 2097 0.366946820339971 3190 871153
SGTC_995 3931-2021 34.6 µM -0.340427558192309 0.380824842112122 no 2098 0.366767284121712 3107 730143
SGTC_1348 1493-0373 93.8 µM -0.34099675885233 0.380625663189657 no 2099 0.366553010866682 3054 3010129
SGTC_396 dithiazanine 1.25 µM -0.341000179809714 0.380624466198434 no 2100 0.366551723186955 3008 10578 An antihelmenthic.
SGTC_3164 9100705 49.47 µM -0.341362435588011 0.380497719558479 no 2101 0.366415375294567 3137 17174235
SGTC_2078 5212016 200 µM -0.342172862774396 0.380214212445365 no 2102 0.366110403169607 3056 1899708
SGTC_1174 0739-0097 51.1 µM -0.342490867013315 0.380102984408046 no 2103 0.365990757978425 3043 728447
SGTC_1706 st031321 9.9705 µM -0.343282253527319 0.379826224966613 no 2104 0.365693065103115 3116 6103185
SGTC_3040 9091894 49.47 µM -0.343771884568802 0.379655024635661 no 2105 0.365508922925196 2993 25236966
SGTC_15 0266-0086 27.098 µM -0.346480701458696 0.378708309264653 no 2106 0.364490742552343 3116 1712902 YIL048W NEO1
SGTC_3133 9127736 49.47 µM -0.346538829572484 0.378688001786735 no 2107 0.364468904010332 3202 27243420
SGTC_230 MPP+ 141.667 µM -0.346598156349072 0.378667275892659 no 2108 0.364446615588237 3059 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1477 0139-0234 16 µM -0.348201603482076 0.378107241700476 no 2109 0.363844391820677 3045 620880
SGTC_2023 5144124 124 µM -0.348521699850549 0.377995472618134 no 2110 0.363724210014851 3007 2830192
SGTC_1227 3909-8010 46.6 µM -0.349389544012129 0.377692496066642 no 2111 0.363398440999818 3024 15982272
SGTC_486 niguldipine 82 µM -0.349799970462697 0.37754923663646 no 2112 0.363244410604371 3028 1236 A calcium channel blocker.
SGTC_1885 st057546 99.9 µM -0.352017651280119 0.376775446603101 no 2113 0.362412512433702 3195 702008
SGTC_554 4483-2211 187 µM -0.355909964166316 0.375418544167808 no 2114 0.36095399672711 3113 747107
SGTC_1265 0819-1001 68.8 µM -0.356711158328716 0.375139429752882 no 2115 0.360654025622182 3081 3106768
SGTC_3154 9100113 49.47 µM -0.35674399121409 0.375127993055357 no 2116 0.360641734652734 3039 25237525
SGTC_2347 9049783 174.81 µM -0.357086762570137 0.375008601872489 no 2117 0.360513427015807 3194 6467988 YPL169C MEX67
SGTC_2994 9053520 71.4286 µM -0.35739370216706 0.374901701464106 no 2118 0.360398545402674 3153 4647384
SGTC_1646 st011709 75.6 µM -0.357684549312014 0.374800414575696 no 2119 0.360289698513899 3142 5757843
SGTC_1674 st016616 23.6 µM -0.359650897144114 0.374115865078888 no 2120 0.359554108242399 2999 625830
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.363366208378299 0.372823529222941 no 2121 0.358165670481131 3178 5282362
SGTC_3284 9108171 64.8615 µM -0.363827753997257 0.372663084514579 no 2122 0.357993318122999 3119 8687505
SGTC_2885 9057732 51.95 µM -0.365876732027064 0.371951075994341 no 2123 0.35722852974819 3195 6471414
SGTC_2376 9072922 81.32 µM -0.366970111631622 0.371571311564261 no 2124 0.356820656241098 3172 17087968
SGTC_2714 st079313 56.9 µM -0.368212165934358 0.37114005944874 no 2125 0.356357519766551 3055 2939799
SGTC_404 fumagillin 50 µM -0.368763514714486 0.370948678138327 no 2126 0.356152000986823 3121 12015870 A methionine aminopeptidase binder.
SGTC_2988 9073640 71.4286 µM -0.369462128427403 0.370706224841232 no 2127 0.355891648280883 3255 9102229
SGTC_2611 pyromycin 23.93 µM -0.370125210171323 0.370476150365041 no 2128 0.355644599441189 3067 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2338 7999974 200 µM -0.37056829893025 0.370322434327651 no 2129 0.355479548657057 3089 315925
SGTC_1447 4239-0816 81.9 µM -0.370851621349506 0.370224155166617 no 2130 0.355374025115954 3057 1341554
SGTC_2824 7998404 51.95 µM -0.372635209258361 0.369605657203074 no 2131 0.354709982012099 3035 837851
SGTC_324 1315-0088 19.6 µM -0.373733800240786 0.369224864572535 no 2132 0.354301187833385 3137 6787421
SGTC_3084 9116877 49.47 µM -0.375273787883682 0.368691291445683 no 2133 0.353728429135592 3132 27241325
SGTC_2170 morpholine 200 µM -0.377152952806101 0.368040543406609 no 2134 0.353029970570281 3174 121171 Reacts with secondary amines.
SGTC_2891 9063876 19.48 µM -0.377614981338723 0.367880602490419 no 2135 0.352858316921296 3152 6472478
SGTC_816 0325-0417 81.3 µM -0.37822713250146 0.36766872874175 no 2136 0.352630935576561 3130 68101
SGTC_2118 5526350 200 µM -0.37900177921866 0.367400670821327 no 2137 0.35234327130715 3162 743594
SGTC_792 4534-1957 155 µM -0.379754984731236 0.367140094334169 no 2138 0.352063650176008 3075 1717904
SGTC_2003 4023581 200 µM -0.3815880631488 0.366506184455002 no 2139 0.351383469834963 3199 16641307
SGTC_2349 9023730 187.07 µM -0.384381223436589 0.365540962220165 no 2140 0.350347957570968 3230 4126287
SGTC_211 3455-0679 143.504 µM -0.384485824264308 0.365504832183255 no 2141 0.350309200300466 3169 748649
SGTC_611 3453-1652 23.7 µM -0.384764662207821 0.365408524960368 no 2142 0.350205891357968 3178 1560575
SGTC_2880 9042983 58.44 µM -0.385439200701622 0.365175582699916 no 2143 0.34995602194182 3199 6464714
SGTC_2543 pimpinellin 60.67 µM -0.386190624184311 0.364916147870716 no 2144 0.349677748493302 3075 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1692 fluoroquinolonic acid 71 µM -0.386817942893282 0.36469960853537 no 2145 0.349445496399835 3195 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1650 st011916 45.8 µM -0.388794852593679 0.364017496824797 no 2146 0.348713954444194 3229 242528
SGTC_2103 5378138 10 µM -0.389367231158962 0.363820083966666 no 2147 0.348502254476291 3145 244142
SGTC_953 1188-0045 9.7 µM -0.389711014097179 0.363701530906757 no 2148 0.348375125572365 3187 6144426
SGTC_2877 9040724 71.43 µM -0.390533513458841 0.363417946139005 no 2149 0.348071039297788 3262 6463895
SGTC_1656 st012921 11 µM -0.391172691665669 0.363197619270383 no 2150 0.34783479612259 3175 6732821
SGTC_340 k038-0059 454 µM -0.395158130637475 0.361824848615218 no 2151 0.346363095160041 3161 23733424
SGTC_719 2810-4230 27.3 µM -0.397475239188478 0.361027543860785 no 2152 0.345508521078994 3142 721079
SGTC_285 1486-1325 46 µM -0.399202411949683 0.360433625207707 no 2153 0.34487203308147 3221 22310230
SGTC_917 harmaline 728.087 nM -0.400040944628438 0.360145402316064 no 2154 0.344563179829098 3190 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2525 harmine 47.85 µM -0.400506804496265 0.359985309939933 no 2155 0.344391636351536 3116 5280953 A monoamine oxidase inhibitor
SGTC_2712 st079126 47.7 µM -0.400732714019425 0.359907685150177 no 2156 0.344308461257842 3088 3152970
SGTC_1491 4138-0063 26.5 µM -0.400781655863829 0.359890869000318 no 2157 0.344290442901223 3194 23883227
SGTC_2490 carminic acid 95.39 µM -0.401581405068567 0.359616117995132 no 2158 0.343996058524078 3188 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_939 1165-0479 45.3 µM -0.401698995877898 0.359575726203543 no 2159 0.343952781800817 3229 1377347
SGTC_1386 3228-0095 33.8 µM -0.402077012543245 0.359445890202404 no 2160 0.343813674892692 3225 870181
SGTC_2890 9046729 58.44 µM -0.402581797192606 0.359272538967115 no 2161 0.343627951415767 3097 903329
SGTC_166 k072-0058 166.424 µM -0.403148911739564 0.359077817185757 no 2162 0.343419340156849 3256 5846229
SGTC_2155 5570423 76 µM -0.406250440344542 0.358013539649569 no 2163 0.342279297926287 3105 797402
SGTC_860 0443-0016 25.1 µM -0.407003664794881 0.357755239672263 no 2164 0.342002648270444 3158 5337942
SGTC_2506 ethyl hematommate 54.16 µM -0.407747467660736 0.357500234503036 no 2165 0.341729542254644 3183 3940691 An allergen.
SGTC_827 3253-0474 693 µM -0.409392319530967 0.356936539948323 no 2166 0.341125887579489 3245 5402065
SGTC_1868 st057644 42.7 µM -0.409921834435917 0.356755140330809 no 2167 0.34093164392724 3086 688665
SGTC_252 miconazole 1.30953 nM -0.411113085538322 0.356347163575988 no 2168 0.340494807635903 3191 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3235 9132602 49.47 µM -0.412652665137325 0.355820135650234 no 2169 0.339930554877802 3251 4912240
SGTC_1185 1319-0113 81.3 µM -0.412825993165561 0.35576081934021 no 2170 0.339867052934733 3223 4672763
SGTC_189 3970-0742 2.116 µM -0.413438127319368 0.355551362770933 no 2171 0.33964282258549 3270 2891807
SGTC_2593 nobiletin 86.24 µM -0.414764671590449 0.355097603169016 no 2172 0.339157092073074 3178 72344 An anti-infammatory.
SGTC_2962 9082311 13.18 µM -0.415512160953198 0.354842006345927 no 2173 0.338883507289141 3087 16459453
SGTC_2707 st078556 66.6 µM -0.416720780313784 0.354428868781734 no 2174 0.338441326457079 3185 17250899
SGTC_2272 7805186 180 µM -0.41893715989476 0.353671697722943 no 2175 0.337631029253821 3267 2956062 YPR165W RHO1
SGTC_643 k048-0106 28.4 µM -0.419670685668197 0.353421234124705 no 2176 0.337363021397941 3233 6763920
SGTC_1910 st062352 60.4 µM -0.419837199199656 0.35336438663597 no 2177 0.337302193936473 3075 2245730
SGTC_164 4100-3994 89.624 µM -0.41992172628488 0.353335530457972 no 2178 0.337271317784561 3278 4615967
SGTC_3065 9113888 49.47 µM -0.420234595899149 0.35322872917542 no 2179 0.337157041945274 3324 16648368
SGTC_293 4049-0273 38.5 µM -0.420699305906167 0.353070116938545 no 2180 0.336987334032154 3161 1380311
SGTC_2797 7859098 81.82 µM -0.420939806049033 0.352988040787819 no 2181 0.336899518569352 3117 972681
SGTC_200 k038-0079 37.545 µM -0.421224196895234 0.352890994761351 no 2182 0.336795688465233 3128 3436683
SGTC_1973 st070275 50.2 µM -0.423249142699674 0.352200275727027 no 2183 0.336056747790704 3211 17118334
SGTC_3139 9095020 49.47 µM -0.424052603166293 0.351926346284327 no 2184 0.335763725291209 3133 25236292
SGTC_350 k064-0020 19.8 µM -0.425415240173188 0.351461948558045 no 2185 0.335266999061694 3313 2790705
SGTC_1875 nocodazole 6 µM -0.425883087276414 0.351302553552328 no 2186 0.33509651967435 3281 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2502 avocadyne acetate 18.59 µM -0.427076524439231 0.350896069283942 no 2187 0.334661795520558 3077 3952079
SGTC_327 1273-0057 3.96 µM -0.42741139941015 0.350782041618191 no 2188 0.334539852974178 3166 3108138
SGTC_2398 5228213 48.84 µM -0.430354264994076 0.349780550858517 no 2189 0.333468979415363 3345 80771 YMR134W ERG29
SGTC_632 0781-2353 4.65 µM -0.431238875088058 0.349479711764437 no 2190 0.333147344990514 3240 6811515 YHR007C ERG11
SGTC_2580 diallyl disulphide 81.36 µM -0.431541709683913 0.349376745177055 no 2191 0.333037265863939 3150 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1459 k035-0031 35.7 µM -0.432041154619206 0.349206953456359 no 2192 0.332855751118906 3123 3877128 YMR208W ERG12
SGTC_2300 7976697 71.57 µM -0.433667046953854 0.348654422908218 no 2193 0.33226511973078 3112 2236109
SGTC_2464 5717415 7.67 µM -0.435156040474528 0.348148696422094 no 2194 0.331724584196425 3174 5285744
SGTC_1719 st032227 49.2 µM -0.435372162983498 0.348075314298409 no 2195 0.331646156317384 3161 3125804
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.435388563806653 0.348069745803681 no 2196 0.331640204985966 3121 23665772 A membrane-active detergent.
SGTC_967 1306-0166 352 µM -0.436250098275787 0.347777279122702 no 2197 0.331327641606514 3311 4437607
SGTC_1881 5652484 16 µM -0.436787248276164 0.347594977649686 no 2198 0.331132823844696 3272 2255129
SGTC_732 3970-1727 52.7 µM -0.437030253452235 0.347512516541499 no 2199 0.33104470383955 3261 1275699
SGTC_206 4546-0025 72.014 µM -0.437134049095038 0.347477296841626 no 2200 0.331007067688373 3246 6620745 YIL048W NEO1
SGTC_332 4112-0506 40.9 µM -0.43811620104634 0.34714410050242 no 2201 0.330651025371219 3173 2790355
SGTC_1945 st075991 56.6 µM -0.438660014899205 0.346959661731675 no 2202 0.330453951942028 3185 1084980
SGTC_530 4358-1714 28 µM -0.439457050005725 0.346689406482654 no 2203 0.330165198271332 3237 1564641
SGTC_144 4161-2749 112.381 µM -0.440461808918387 0.3463488282851 no 2204 0.329801333537979 3198 797501 YMR168C CEP3
SGTC_3342 9147791 14.508 µM -0.441152543506664 0.346114765392333 no 2205 0.329551283357546 3182 1838168
SGTC_1693 xanthone 101.9 µM -0.442166453444688 0.345771297509734 no 2206 0.329184379722889 3213 7020 An insecticide.
SGTC_391 gliotoxin 8.33 µM -0.443108061381523 0.345452435981584 no 2207 0.328843787289901 3337 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_195 4234-0266 16.654 µM -0.444751852058489 0.34489605358694 no 2208 0.328249546435942 3190 2303354
SGTC_2419 paclitaxel 166.5 µM -0.444771214489167 0.344889501879434 no 2209 0.328242549378596 3194 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2875 9039966 71.43 µM -0.444914151860267 0.344841137291402 no 2210 0.328190897553554 3223 6463691
SGTC_578 3460-0051 92 µM -0.445473113230783 0.344652030301036 no 2211 0.327988942909608 3328 2876744
SGTC_1930 st074634 34.3 µM -0.446242554487473 0.344391777559262 no 2212 0.327711023423395 3151 684253 YOR116C RPO31
SGTC_1007 4101-0031 70 µM -0.447941980591418 0.343817231594036 no 2213 0.32709753492908 3308 1146276
SGTC_274 sirtinol 40.1 µM -0.448860421975285 0.343506872750208 no 2214 0.326766174164369 3219 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_521 r062-0005 13.8 µM -0.449984199061587 0.343127270555071 no 2215 0.326360916972503 3219 2832033
SGTC_82 0054-0107 293.755 µM -0.451827503986835 0.342504960879123 no 2216 0.325696627036348 3244 3104697
SGTC_2928 9011484 9.79 µM -0.453739275086044 0.341859988010876 no 2217 0.325008247515303 3295 2994751
SGTC_1825 st052143 62.6 µM -0.455440647031624 0.34128638518546 no 2218 0.324396129202044 3340 674173
SGTC_205 1486-1330 71.903 µM -0.455656497132319 0.341213639363306 no 2219 0.324318504678447 3218 4118834
SGTC_569 4130-2812 160 µM -0.457534204585895 0.340581063405823 no 2220 0.323643561460741 3253 743552
SGTC_2984 9022109 38.96 µM -0.459274876541048 0.339995053189023 no 2221 0.323018393403952 3328 6459207
SGTC_965 1291-5240 308 µM -0.460633991069637 0.339537765652282 no 2222 0.322530610201297 3331 2834598
SGTC_2899 9053889 58.44 µM -0.461812713875925 0.339141363861981 no 2223 0.322107816357003 3328 6470052
SGTC_2778 tioconazole 65.09 nM -0.46195835323724 0.339092398023301 no 2224 0.32205559321234 3264 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_193 1273-0060 1.558 µM -0.466231379768093 0.337656963898682 no 2225 0.320524945154543 3281 2847393 YHR072W ERG7
SGTC_2240 6690706 185.951 µM -0.466307504136735 0.337631412827821 no 2226 0.320497704069788 3109 805876
SGTC_3137 9097352 49.47 µM -0.466638256044125 0.337520404961107 no 2227 0.320379355818611 3465 44120435
SGTC_924 2046-0044 21.3 µM -0.466687684991133 0.337503816695729 no 2228 0.320361670929948 3281 3623589
SGTC_1246 0422-0085 105 µM -0.466804310739637 0.337464678556607 no 2229 0.320319945714616 3357 264295
SGTC_507 nimesulide 162 µM -0.467307696779175 0.337295768689982 no 2230 0.32013987526642 3388 4495 A COX2 inhibitor.
SGTC_2539 epi(13)torulosol 80 µM -0.467904964337226 0.337095399656726 no 2231 0.319926276613839 3313 6708597
SGTC_3024 9090631 49.47 µM -0.468539800766635 0.336882477820216 no 2232 0.319699307776377 3321 25236383
SGTC_419 nsc-638432 893 µM -0.469434717287866 0.336582414839741 no 2233 0.319379468899972 3262 368090
SGTC_2799 7812892 81.82 µM -0.471269917466521 0.335967402963897 no 2234 0.318723997579568 3353 20205235
SGTC_687 k029-0044 34.9 µM -0.472085936591045 0.335694079688623 no 2235 0.318432725094629 3338 5829338
SGTC_1329 1447-1697 50.6 µM -0.473289419267894 0.335291135222383 no 2236 0.318003354903746 3306 2840515
SGTC_2250 alverine citrate 130 µM -0.47419377498583 0.334988467674857 no 2237 0.317680866020133 3275 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_971 1315-0384 26.7 µM -0.475401511095644 0.334584432615501 no 2238 0.317250408810815 3248 6769120
SGTC_641 4092-0595 30 µM -0.475573783420828 0.334526816365163 no 2239 0.3171890282169 3321 786260
SGTC_2514 salinomycin 42.74 µM -0.476065684405322 0.334362322187243 no 2240 0.317013791681068 3359 23682228 A polyether potassium ionophore.
SGTC_2198 6589944 200 µM -0.477320615685718 0.333942810925497 no 2241 0.316566916494989 3299 5290268
SGTC_2283 7944793 200 µM -0.477854990559461 0.333764237567653 no 2242 0.316376709294627 3302 2970533
SGTC_2051 5263410 176 µM -0.478648457953151 0.333499152087001 no 2243 0.316094369430265 3382 227584
SGTC_3196 9111891 49.47 µM -0.47985946663248 0.333094732628024 no 2244 0.315663662384782 3311 18891510
SGTC_1353 1498-1206 8.11 µM -0.480591257280458 0.33285044327468 no 2245 0.315403515159063 3358 6756808
SGTC_1220 1838-0075 193 µM -0.480646916627933 0.332831865744778 no 2246 0.315383732333887 3265 5529645
SGTC_2411 st077133 39.94 µM -0.480884928787222 0.332752428588269 no 2247 0.315299142398661 3475 1403142 YNL221C POP1
SGTC_1641 st009299 47.1 µM -0.481221506903426 0.332640107611294 no 2248 0.31517953847717 3328 4046054
SGTC_1784 st039334 36.3 µM -0.482502692539846 0.332212694959212 no 2249 0.31472444307169 3432 3496984
SGTC_1928 4'-methoxychalcone 40.3 µM -0.485118614798952 0.331340682578182 no 2250 0.313796104163622 3422 641818
SGTC_3242 9133940 49.47 µM -0.485459628906579 0.331227073432783 no 2251 0.313675171662865 3378 17248444
SGTC_1848 st056003 16.4 µM -0.486216046269837 0.330975127784462 no 2252 0.313406997793078 3366 146492
SGTC_2975 9084847 53.72 µM -0.486356756274783 0.330928268877983 no 2253 0.313357122522312 3312 27211724
SGTC_619 1652-1634 108 µM -0.486631784299619 0.330836687356775 no 2254 0.313259647503501 3263 5400454
SGTC_846 0335-0850 148 µM -0.487123619586323 0.330672936475657 no 2255 0.313085364508151 3312 6819598
SGTC_3112 9123419 49.47 µM -0.487597916900684 0.330515055349026 no 2256 0.312917335678293 3342 17015854
SGTC_2004 4023728 41.89 µM -0.489802295592249 0.329781671710322 no 2257 0.31213690307043 3392 360084 YDR527W RBA50
SGTC_95 0471-0001 561.058 µM -0.491487594342664 0.329221423757969 no 2258 0.311540812110382 3279 4015405
SGTC_2694 st077685 81.9 µM -0.491844723834722 0.329102751509087 no 2259 0.311414558571864 3195 2838096
SGTC_1771 st048882 4.1505 µM -0.492263864323612 0.328963495297901 no 2260 0.311266410996693 3230 4580403
SGTC_2214 7179297 48.276 µM -0.493444824172762 0.328571258158352 no 2261 0.310849158503107 3316 769744
SGTC_3163 9099914 49.47 µM -0.493533004393642 0.328541978062866 no 2262 0.310818012731375 3332 16268368
SGTC_651 3253-0966 34.4 µM -0.493593209145011 0.328521987780202 no 2263 0.31079674883833 3278 781462
SGTC_183 3914-0051 30.55 µM -0.494934915062294 0.328076617480566 no 2264 0.310323031844268 3377 1596232
SGTC_283 0987-0079 11.7 µM -0.495316424190217 0.327950022664403 no 2265 0.310188389558759 3368 411556
SGTC_1373 2887-0003 58.5 µM -0.496752715707163 0.327473600537802 no 2266 0.309681721541946 3294 776948
SGTC_398 bronopol 33.3 µM -0.497553641028857 0.327208053157075 no 2267 0.309399343000409 3222 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2441 5730946 39.09 µM -0.497800560760667 0.327126204364841 no 2268 0.309312310333674 3373 1774275
SGTC_2257 7960413 200 µM -0.49792295315621 0.327085636894502 no 2269 0.309269174220367 3260 2974689 YIL048W NEO1
SGTC_1044 1222-0021 1.78 µM -0.498561332163994 0.326874076634114 no 2270 0.309044225829781 3318 4306703
SGTC_1026 k007-1105 30.6 µM -0.499551069610575 0.326546185401807 no 2271 0.308695609284931 3363 7066794
SGTC_2448 5185112 27.17 µM -0.499817887216231 0.326457814010827 no 2272 0.308601657241514 3372 5718189
SGTC_1001 4048-4355 44.4 µM -0.500108765264283 0.326361484771297 no 2273 0.308499247288956 3297 21824233
SGTC_981 1488-1094 54.9 µM -0.500140579793276 0.326350949548461 no 2274 0.308488047194691 3319 3449522
SGTC_2625 euphol 100 µM -0.501145291162704 0.326018315690309 no 2275 0.308134436934931 3389 6708538 A triterpene alcohol.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.50324677866179 0.325323015446768 no 2276 0.307395389869949 3260 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.503887393582827 0.325111181686654 no 2277 0.307170254902407 3307 65057 A dermal irritant. YDR527W RBA50
SGTC_942 3253-1115 227 µM -0.504278754237915 0.324981797270857 no 2278 0.307032752537579 3427 46497897
SGTC_2140 5586273 200 µM -0.504606946584325 0.324873312661483 no 2279 0.306917464920134 3357 854421
SGTC_132 0417-1715 25.805 µM -0.508245725696859 0.323671504047731 no 2280 0.305640513599322 3443 6769098
SGTC_2811 7967822 32.47 µM -0.508849744546402 0.32347218732171 no 2281 0.305428774159487 3390 2232244
SGTC_559 1550-0661 158 µM -0.509996134516014 0.323094035954343 no 2282 0.305027084946501 3372 5830875
SGTC_1323 1348-1351 11.2 µM -0.511207291795236 0.322694718793597 no 2283 0.304602956657662 3302 6989654
SGTC_2745 rifampicin 24.3 µM -0.51356708140308 0.3219172862287 no 2284 0.30377734977932 3319 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_172 1112-0046 2.638 µM -0.51841246217299 0.320323419887824 no 2285 0.302085260781054 3271 2802135 YIL048W NEO1
SGTC_887 0885-0007 9.62 µM -0.518685980791951 0.320233545560269 no 2286 0.301989869754462 3396 5719458
SGTC_2728 chlorpromazine 9.18 µM -0.522653557102837 0.318931044529786 no 2287 0.300607681559623 3362 2726 A thorazine and dopamine antagonist.
SGTC_440 fluspirilene 35.1 µM -0.523821534580683 0.318548038189327 no 2288 0.300201336970477 3483 3396 An atypical antipsychotic.
SGTC_38 0929-0051 58.268 µM -0.523901448477796 0.318521839686961 no 2289 0.300173543647688 3369 1379719
SGTC_1023 4482-3888 16 µM -0.524163572101533 0.318435912988221 no 2290 0.300082387616414 3437 3303168
SGTC_1842 st055362 61.2 µM -0.524777052974043 0.318234846112783 no 2291 0.299869092658426 3324 676032
SGTC_1478 0453-0656 35.7 µM -0.5254037742294 0.318029495022002 no 2292 0.299651265182053 3425 5258496
SGTC_764 1951-2361 146 µM -0.529225495534885 0.316778484601893 no 2293 0.298324516180698 3316 5438930
SGTC_2233 sulbentine 40.3845 µM -0.529381574703059 0.316727437690051 no 2294 0.298270388608053 3383 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2197 6588183 93.1375 µM -0.529767110278642 0.316601360224432 no 2295 0.298136705726022 3359 884136
SGTC_2081 5214970 32.255 µM -0.530636855636494 0.316317015211984 no 2296 0.297835225373146 3395 2063512
SGTC_75 0159-0059 199.013 µM -0.530848541760796 0.31624782529292 no 2297 0.297761869527902 3559 5377270
SGTC_589 1227-0070 34.1 µM -0.531214548148886 0.316128210748454 no 2298 0.297635056345474 3439 2841384
SGTC_642 0335-0876 158 µM -0.531344975390739 0.316085590472337 no 2299 0.297589872125456 3370 6812350
SGTC_3071 9117417 49.47 µM -0.532563920448261 0.31568738871861 no 2300 0.297167741539408 3297 45595590 YGL055W OLE1
SGTC_2130 NSC 7 2.4545 µM -0.53399704471018 0.315219493007449 no 2301 0.296671789360988 3415 21448
SGTC_1092 toremifene 6.32 µM -0.536688939456943 0.314341426995545 no 2302 0.295741248690549 3398 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_97 0535-0701 19.132 µM -0.539375894880913 0.313466018487615 no 2303 0.294813755149105 3415 2832013 YGL099W LSG1
SGTC_633 0437-0093 97.7 µM -0.539484858595398 0.313430540288108 no 2304 0.294776170945962 3400 2831118
SGTC_1467 k284-1082 293 µM -0.540257178565679 0.313179125133825 no 2305 0.294509842575127 3420 3334705
SGTC_3147 9097027 49.47 µM -0.541086870133747 0.312909130398255 no 2306 0.294223853859403 3350 25236841
SGTC_1933 st074711 15.9 µM -0.541190586634705 0.31287538646248 no 2307 0.29418811255059 3408 17250958
SGTC_208 k072-0098 12.366 µM -0.542512885443062 0.312445316936648 no 2308 0.293732616618606 3424 5948901
SGTC_2517 totarol 10 µM -0.543853959631322 0.312009401609512 no 2309 0.293270986711333 3397 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1299 1079-1439 3.74 µM -0.544191153236934 0.311899838414032 no 2310 0.293154969511416 3344 323161
SGTC_289 k017-0060 526 µM -0.544443642486359 0.311817808818801 no 2311 0.293068110224161 3354 5512909
SGTC_2929 9013348 24.6 µM -0.544812632647654 0.311697946787165 no 2312 0.29294119472054 3385 2995952
SGTC_2512 diallyl trisulfide 49.23 µM -0.545921807970208 0.311337764613515 no 2313 0.292559843498233 3434 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1902 st060212 70.5 µM -0.548286891448687 0.310570354938772 no 2314 0.291747463412508 3479 688944
SGTC_3263 9137018 49.47 µM -0.548429130524559 0.310524228186462 no 2315 0.291698639388505 3383 43844957
SGTC_2121 5257820 149.641 µM -0.549128099270301 0.310297602703951 no 2316 0.2914587714545 3474 791256
SGTC_102 gallobenzophenone 83.616 µM -0.549424404262877 0.310201553954542 no 2317 0.291357115047506 3503 70837
SGTC_1540 guanosine 70.6 µM -0.549714766092047 0.310107444270307 no 2318 0.29125751367627 3414 6802 Guanosine is a purine nucleoside
SGTC_1363 1636-0063 10.4 µM -0.551059787447477 0.30967166934431 no 2319 0.290796345166764 3405 6072185
SGTC_94 0334-0113 514.748 µM -0.556061488317468 0.308053512586421 no 2320 0.289084410555706 3401 6795178
SGTC_1696 st025591 34.7925 µM -0.55638296640231 0.307949634638661 no 2321 0.288974540401008 3442 2787147
SGTC_2260 7964312 200 µM -0.557960454074165 0.30744013037945 no 2322 0.288435694292404 3501 231951
SGTC_1905 st060207 84.5 µM -0.561842487760505 0.306187875947209 no 2323 0.287111670576811 3391 1948547
SGTC_2569 tetrandrine 100 µM -0.562689763262002 0.305914864528865 no 2324 0.286823078048214 3359 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_511 blebbistatin 171 µM -0.562919479949401 0.305840863162489 no 2325 0.286744857396589 3520 3476986 A myosin inhibitor.
SGTC_471 1-acyl-paf 4 µM -0.563389726947769 0.305689401632027 no 2326 0.28658476550194 3376 16759367
SGTC_2671 danthron 100 µM -0.564661294252904 0.305280009904156 no 2327 0.28615208285181 3427 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_601 0986-0029 62.9 µM -0.565209890593483 0.305103459868694 no 2328 0.285965505062221 3469 24747981
SGTC_2322 7413319 38.22 µM -0.565267240097157 0.305085006189186 no 2329 0.285946003816668 3468 1840400
SGTC_1680 diphenhydramine 100 µM -0.565531244313775 0.305000062426911 no 2330 0.285856239423118 3392 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1186 1319-0216 26 µM -0.565697802261278 0.304946477555965 no 2331 0.285799614747597 3519 4565136
SGTC_1736 st036774 51 µM -0.568067003100413 0.304184713744628 no 2332 0.284994736148535 3530 1272247
SGTC_1682 st012968 530 nM -0.568104681396856 0.304172605977532 no 2333 0.284981944596674 3344 24207270
SGTC_565 1418-0001 44.5 µM -0.56990431225416 0.303594552174434 no 2334 0.284371299972326 3515 2862145
SGTC_1513 0337-0559 19 µM -0.570670507871375 0.303348593831446 no 2335 0.284111506988622 3360 775073
SGTC_2333 9017922 200 µM -0.573319391336808 0.302498956207707 no 2336 0.283214229061037 3485 3163164
SGTC_2884 9058502 51.95 µM -0.574267370082692 0.302195148507805 no 2337 0.282893443103473 3489 6471554
SGTC_1103 duloxetine 36.1 µM -0.57656893282236 0.301458115473025 no 2338 0.282115345541061 3530 60835 A selective serotonin reuptake inhibitor.
SGTC_2161 5662504 8.5105 µM -0.577750089425406 0.301080186239695 no 2339 0.281716428177383 3434 2859334
SGTC_3171 9103192 49.47 µM -0.578591409528569 0.300811123210246 no 2340 0.281432451262562 3525 13018434
SGTC_636 0kpi-0074 126 µM -0.579602943325787 0.300487767741986 no 2341 0.281091203859088 3456 616434
SGTC_1872 amphotericin b 148 nM -0.580422163103198 0.300226004120444 no 2342 0.280814981396855 3465 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1964 st076914 61 µM -0.582228231961985 0.299649279122685 no 2343 0.280206479673105 3507 24208661
SGTC_2677 mitomycin C 100 µM -0.583372249959381 0.299284224131136 no 2344 0.279821367259846 3483 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1383 3049-0032 20.7 µM -0.58379708286835 0.299148711768736 no 2345 0.279678420555108 3531 712864
SGTC_344 k064-0035 6.43 µM -0.584125125720146 0.299044092366188 no 2346 0.279568065777838 3392 5088750
SGTC_2409 alverine citrate 63.97 µM -0.584734853244261 0.298849682256879 no 2347 0.27936300745796 3576 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_374 0880-0231 82.3 µM -0.585166486618148 0.298712091751386 no 2348 0.27921788841741 3479 6833587
SGTC_2608 thymoquinone 42.66 µM -0.585230995668168 0.298691530864367 no 2349 0.279196203039428 3466 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_345 1362-0200 395 µM -0.587033912553381 0.298117149948638 no 2350 0.278590465447848 3427 1419823
SGTC_1252 0493-0875 34.8 µM -0.588155159205527 0.297760192407016 no 2351 0.278214076068564 3465 3960963
SGTC_2141 5621638 7.665 µM -0.589356200264091 0.297378048125097 no 2352 0.277811175899912 3520 2856238
SGTC_3330 9141424 71.43 µM -0.590094599099801 0.297143217468106 no 2353 0.27756361477153 3505 27261020
SGTC_334 1502-1024 68.5 µM -0.590800983607808 0.296918647605474 no 2354 0.277326887938237 3518 3296216
SGTC_2772 vinpocetine 57.06 µM -0.591867505529571 0.296579732063437 no 2355 0.276969657365918 3557 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2724 maprotiline 69.64 µM -0.592149416486626 0.296490177024471 no 2356 0.276875269198359 3519 4011 A tricyclic antidepressant.
SGTC_1080 nisoldipine 24.4 µM -0.594705763708212 0.295678664999202 no 2357 0.276020084223832 3443 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1852 st056254 31.4 µM -0.59527118116462 0.295499311271602 no 2358 0.275831108202407 3433 442583
SGTC_254 nsc-64875 3.808 µM -0.595472852375182 0.295435352090099 no 2359 0.275763720250466 3526 56993
SGTC_2068 5226020 147 µM -0.596100973029411 0.295236187064365 no 2360 0.27555388709732 3490 1810509
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.596590219740588 0.295081099136234 no 2361 0.275390501291775 3508 688669
SGTC_2511 berberine 10.47 µM -0.597144820326013 0.294905339856261 no 2362 0.27520534797354 3497 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3345 9148410 3.559 µM -0.597297372654562 0.294857002737342 no 2363 0.275154429152393 3513 4903596
SGTC_709 3807-1509 243 µM -0.597382543086494 0.294830017564579 no 2364 0.275126003036835 3545 1886677 YPL242C IQG1
SGTC_3328 9140624 29.0385 µM -0.597628716733012 0.294752026963681 no 2365 0.275043849315449 3530 4904392
SGTC_3192 9110362 49.47 µM -0.599224653449919 0.294246647027775 no 2366 0.27451154237637 3584 16649480
SGTC_1167 k781-0610 148 µM -0.599504120796045 0.294158190238522 no 2367 0.274418381478156 3510 4525169
SGTC_1213 1315-0166 115 µM -0.601747223388915 0.293448650658257 no 2368 0.2736712052989 3469 768401
SGTC_1428 4049-0204 61.7 µM -0.603293929253829 0.29295985799989 no 2369 0.273156585393306 3549 X1428
SGTC_2404 5161160 200 µM -0.604110464498035 0.292701967583533 no 2370 0.272885101352973 3516 2831543
SGTC_1056 3448-1962 115 µM -0.604231878597828 0.29266362976663 no 2371 0.272844744667046 3497 715507
SGTC_969 1313-0238 134 µM -0.604815092761588 0.292479506098448 no 2372 0.272650932088503 3484 5212874
SGTC_2244 6635614 200 µM -0.605087827630171 0.292393420798532 no 2373 0.272560320829565 3374 836499
SGTC_672 1441-0018 53.7 µM -0.605624476244326 0.292224068878582 no 2374 0.272382072630758 3484 251141
SGTC_1625 st003711 30.1 µM -0.606134493920281 0.292063163273591 no 2375 0.272212723597862 3596 24207034 YER133W GLC7
SGTC_3347 9188721 44.724 µM -0.6068052305659 0.291851615205953 no 2376 0.2719900882576 3514 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2649 anisomycin 9.56 µM -0.607840909802584 0.291525105753115 no 2377 0.271646496727076 3508 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2926 9010726 65.15 µM -0.607975341272755 0.291482737223949 no 2378 0.271601914295279 3510 2994293
SGTC_2414 st077232 92.9 µM -0.608703281090165 0.291253363614954 no 2379 0.271360565910291 3427 729801
SGTC_133 0724-0033 378.92 µM -0.608951643823015 0.29117512387757 no 2380 0.271278245725552 3429 280309
SGTC_748 act1.228 77.9 µM -0.610610583419813 0.290652773195264 no 2381 0.270728707260427 3509 4421505 YNR035C ARC35
SGTC_1834 st055981 52.8 µM -0.610865285129989 0.290572614042281 no 2382 0.270644384303731 3583 471719 YDL150W RPC53
SGTC_2699 st077704 54.6 µM -0.61197519715304 0.290223425819529 no 2383 0.270277083878088 3512 645852
SGTC_2228 7354201 200 µM -0.613307262809816 0.28980460580938 no 2384 0.269836596001072 3558 753451
SGTC_2320 7373003 200 µM -0.613698796685544 0.289681556043471 no 2385 0.269707191842514 3530 5415828
SGTC_110 0850-0284 111.64 µM -0.61411055639291 0.289552176241112 no 2386 0.269571136473075 3433 3906265
SGTC_1603 st002045 67.8 µM -0.614743873127187 0.289353233559911 no 2387 0.26936194044989 3558 5887985
SGTC_3132 9126706 49.47 µM -0.616158363688698 0.288909134173806 no 2388 0.268895002633424 3572 850858
SGTC_2484 5809818 12.04 µM -0.617185123158894 0.288586969520715 no 2389 0.268556313594784 3525 2870548
SGTC_2638 epoxomicin 18 µM -0.618584032885244 0.288148308460389 no 2390 0.268095211636668 3522 9915668 A protesome inhibitor.
SGTC_2939 9044578 71.43 µM -0.618681220894878 0.288117844564172 no 2391 0.268063191798637 3527 2653634
SGTC_684 1140-0066 328 µM -0.618882573363894 0.288054734817319 no 2392 0.267996859768003 3554 6813534
SGTC_3215 9129942 49.47 µM -0.619187639707994 0.287959130544255 no 2393 0.26789637677318 3507 17682944
SGTC_2971 9092186 9.93 µM -0.620292132582407 0.2876131205802 no 2394 0.267532736818119 3434 25236400
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.622540616863748 0.286909334653953 no 2395 0.266793222386336 3482 279621
SGTC_3059 1327-0034 3 µM -0.623137809187035 0.286722547940606 no 2396 0.266596982793302 3505 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2861 9024595 19.48 µM -0.623497797362423 0.286609980567058 no 2397 0.266478724624434 3495 16482810
SGTC_1130 3454-2858 15.9 µM -0.624855975585045 0.286185470570248 no 2398 0.266032794367312 3474 715628 YIL048W NEO1
SGTC_966 1300-0360 30.2 µM -0.626330078656524 0.285725065528301 no 2399 0.26554923064957 3541 70588
SGTC_3074 9116018 49.47 µM -0.62787998590064 0.285241364970267 no 2400 0.265041281465646 3578 17027303
SGTC_2374 9071832 200 µM -0.629432069214516 0.284757376628476 no 2401 0.264533114235544 3539 17381698
SGTC_44 0929-0055 61.211 µM -0.629855290876639 0.284625470855052 no 2402 0.264394633399782 3487 1379590
SGTC_1017 4239-0030 168 µM -0.631041626934314 0.284255880300064 no 2403 0.26400665343735 3508 1149593
SGTC_3207 9114163 49.47 µM -0.631456158871742 0.284126791333575 no 2404 0.263871153130866 3630 849233
SGTC_1644 st010134 20.9 µM -0.633158058951728 0.283597098423933 no 2405 0.263315215643926 3567 3818134
SGTC_1763 st044482 94.5 µM -0.633195372882782 0.283585490280023 no 2406 0.263303033493097 3550 88505
SGTC_2157 5649910 96.377 µM -0.63357609169573 0.283467063915229 no 2407 0.263178753901404 3547 2858091
SGTC_248 streptozotocin 5.23457 mM -0.634229405200468 0.283263899522475 no 2408 0.262965559971159 3600 5300 DNA alkylating agent.
SGTC_2770 toltrazuril 17.5 µM -0.635154768230083 0.2829762540081 no 2409 0.262663740051203 3569 68591 Kills coccidiodes.
SGTC_3042 9091578 49.47 µM -0.635239568864004 0.282949901075252 no 2410 0.262636090022573 3546 25236497
SGTC_2620 irigenin 100 µM -0.638126881652478 0.282053333755926 no 2411 0.261695544534747 3594 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1796 st049173 110.4 µM -0.638546127272755 0.28192326358919 no 2412 0.261559118626562 3553 94134
SGTC_1412 3909-8563 178 µM -0.638636754233626 0.281895150543601 no 2413 0.261529632681754 3637 23767530
SGTC_1563 conessine 56.1 µM -0.63871993406511 0.281869348832575 no 2414 0.261502571200486 3636 441082 An anti-amoebic, histamine inhibitor.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.64054529242179 0.28130342410535 no 2415 0.260909076638513 3591 7104
SGTC_1621 st003705 32.4 µM -0.640585160209154 0.28129106982473 no 2416 0.260896121814548 3611 24207032
SGTC_2556 citropten 84.59 µM -0.641358372340878 0.281051517683427 no 2417 0.260644936119369 3537 2775 A potential DNA crosslinker.
SGTC_3213 9129884 49.47 µM -0.64149752520543 0.281008416609775 no 2418 0.260599744139552 3522 17190742
SGTC_1155 4088-0394 48.2 µM -0.642578485304471 0.280673709891521 no 2419 0.260248823554699 3543 2326248
SGTC_458 nppb 133 µM -0.643325522582565 0.280442511236532 no 2420 0.26000644933332 3628 4549 A chloride channel blocker.
SGTC_937 3122-0005 46.7 µM -0.644104107697729 0.280201647082181 no 2421 0.259753963437771 3584 759535
SGTC_234 nsc-17383 10.7 µM -0.644871743017815 0.279964268535841 no 2422 0.259505152359618 3621 408974
SGTC_986 1493-0483 84 µM -0.645213742087547 0.279858542377503 no 2423 0.259394340986882 3557 40079
SGTC_1060 3448-7350 82 µM -0.645392686666985 0.279803230872307 no 2424 0.259336370763277 3559 570178
SGTC_1906 st060206 94.7 µM -0.64603258117532 0.279605483824773 no 2425 0.259129127686955 3582 5133468
SGTC_2486 5283202 22.39 µM -0.646419762037251 0.279485866003917 no 2426 0.259003772743872 3542 1377751
SGTC_503 tyrphostin 8 294 µM -0.647328278835892 0.279205281351943 no 2427 0.258709751557913 3575 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_3267 9137951 49.47 µM -0.647790239602435 0.279062662769262 no 2428 0.258560314553165 3567 16643986
SGTC_1889 st059080 5.18 µM -0.649384511244961 0.278570744401663 no 2429 0.258044936418076 3608 176925 Isolated from Daphnopsis sellowiana.
SGTC_1124 fisetin 1.16336 µM -0.649450896777009 0.278550270064838 no 2430 0.258023487613107 3561 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_3060 1327-0027 12.5 µM -0.649508545688421 0.278532490833171 no 2431 0.258004862313016 3518 16000455 YPR107C YTH1
SGTC_353 1988-1175 58.3 µM -0.651575291729719 0.277895460740275 no 2432 0.257337595717927 3485 2788357
SGTC_2452 5863136 48.41 µM -0.651582210234431 0.277893329454609 no 2433 0.257335363526743 3581 2184096
SGTC_3167 9103034 49.47 µM -0.652720159619994 0.277542886142348 no 2434 0.25696835173089 3601 5127859
SGTC_3108 9121785 49.47 µM -0.652925498846182 0.277479672806736 no 2435 0.256902154673211 3558 17140271
SGTC_1934 st074720 32.6 µM -0.654832236450386 0.276893023133938 no 2436 0.256287886502251 3599 17250992
SGTC_2055 5235184 200 µM -0.655281040278898 0.276755027142537 no 2437 0.256143412764265 3612 2836034
SGTC_304 1310-0298 97 µM -0.655669280917538 0.276635680008364 no 2438 0.256018469097456 3562 1550234
SGTC_2098 5376439 882.5 nM -0.658624708470639 0.275727994371174 no 2439 0.255068396137978 3651 2844116
SGTC_1739 st037196 92.5 µM -0.659035585414101 0.275601919795343 no 2440 0.254936458859899 3624 612214
SGTC_3295 9122362 53.5725 µM -0.6591815491888 0.275557138706379 no 2441 0.254889596823606 3605 4730473
SGTC_1778 st046819 58.9 µM -0.660242794807759 0.275231660519776 no 2442 0.254549016848067 3640 671715
SGTC_2339 9000433 200 µM -0.660726476882077 0.275083380702648 no 2443 0.254393870429981 3568 2988954
SGTC_1655 st012546 55.1 µM -0.662500994484528 0.274539713566273 no 2444 0.253825098847305 3583 720985 YLR208W SEC13
SGTC_3029 9088683 49.47 µM -0.663679175595965 0.274179041855067 no 2445 0.25344783518927 3622 25236615
SGTC_2287 7945887 168.79 µM -0.664413889517969 0.273954245461309 no 2446 0.253212722775272 3635 1245853
SGTC_1950 st077106 7.18 µM -0.665985561874606 0.273473675567721 no 2447 0.252710164502656 3601 13831864
SGTC_3182 9108849 49.47 µM -0.666120961814056 0.273432293892375 no 2448 0.252666893578761 3640 17133045
SGTC_1125 tnp00248 1.32998 µM -0.666160803880005 0.273420117731076 no 2449 0.252654161649972 3695 24207736
SGTC_1358 1509-0022 2.48 µM -0.667626941726255 0.272972237126448 no 2450 0.252185877811227 3640 3258434
SGTC_2180 6301957 200 µM -0.667670858000734 0.272958827051845 no 2451 0.252171858035169 3593 845462
SGTC_2202 7226349 200 µM -0.66929767516836 0.272462299821775 no 2452 0.251652804761092 3583 844334
SGTC_323 4013-0906 34.3 µM -0.669623578194003 0.272362883640192 no 2453 0.251548889832637 3641 2910086
SGTC_1954 st077032 68.9 µM -0.669707862880895 0.272337175668242 no 2454 0.251522019156748 3557 698907
SGTC_2641 levomentholum 100 µM -0.671653517591157 0.271744059934323 no 2455 0.250902149703087 3595 16666
SGTC_1259 0671-0132 43 µM -0.673542924926943 0.2711687066854 no 2456 0.250300974938667 3580 X1259
SGTC_3092 9117248 49.47 µM -0.674763637962236 0.270797304269918 no 2457 0.249912972924158 3675 17141857
SGTC_1826 st055655 41.6 µM -0.675335343916016 0.270623449863278 no 2458 0.249731366771811 3654 676168
SGTC_1365 1672-3266 55.4 µM -0.675484857090098 0.270577992463907 no 2459 0.249683884492502 3631 6415873
SGTC_3006 9075424 71.4286 µM -0.675664117416817 0.270523495885256 no 2460 0.249626961456453 3630 7465181
SGTC_696 1560-0013 611 µM -0.675750222216449 0.27049732128455 no 2461 0.249599621847401 3685 1650269
SGTC_2911 7942208 15.64 µM -0.67592951463735 0.27044282306979 no 2462 0.249542698828387 3620 1243384
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.676892593848155 0.270150176807756 no 2463 0.249237051733628 3614 6708514
SGTC_1314 1222-0010 41.1 µM -0.679399176580375 0.269389256888703 no 2464 0.248442485738261 3643 3526027
SGTC_2330 7979373 200 µM -0.679522786724068 0.269351760545029 no 2465 0.248403337302601 3615 1863007
SGTC_1975 st070967 30.8 µM -0.679638937245052 0.269316529414998 no 2466 0.248366554392527 3653 261391
SGTC_1312 1218-2183 165 µM -0.680619185468487 0.269019289613664 no 2467 0.248056242001199 3659 6744073
SGTC_1983 st071813 46.9 µM -0.684015595765573 0.267990674427243 no 2468 0.246982658866448 3670 11838595
SGTC_2142 5622915 118.518 µM -0.684982289112057 0.267698270287439 no 2469 0.246677548559991 3643 5322196
SGTC_2848 9016370 25.97 µM -0.685133943656377 0.26765241261377 no 2470 0.246629701276047 3663 7894410
SGTC_337 1315-0038 354 µM -0.685901062484725 0.267420510022984 no 2471 0.246387750077773 3657 1626437
SGTC_679 0422-0091 41.4 µM -0.688368352864417 0.26667532769365 no 2472 0.245610423867848 3667 627384 YHR062C RPP1
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.688766704369317 0.266555114246181 no 2473 0.24548504580992 3671 4174840
SGTC_2854 9024559 71.43 µM -0.688942860636717 0.266501963021103 no 2474 0.24542961295348 3635 3163529
SGTC_317 4495-0002 170 µM -0.689017068012752 0.266479574205194 no 2475 0.245406263389195 3637 15991618
SGTC_2831 7999036 19.48 µM -0.691157544467431 0.265834189240984 no 2476 0.244733270443779 3659 2988270
SGTC_2648 atorvastatin 78.68 µM -0.691598610175651 0.265701299981656 no 2477 0.244594717363648 3671 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2755 lomerizine 42.69 µM -0.692934976160233 0.265298870270489 no 2478 0.244175179396 3666 3949 A calcium channel blocker.
SGTC_2109 5483026 200 µM -0.69319994978057 0.265219113589576 no 2479 0.244092039848907 3683 759335
SGTC_57 miconazole 162.5 nM -0.693445147983682 0.265145320128071 no 2480 0.2440151187457 3607 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_885 0865-0106 16.8 µM -0.693639344662828 0.26508688319676 no 2481 0.243954206605714 3637 2793380
SGTC_407 eburnamonine 100 µM -0.695233125488057 0.26460753598829 no 2482 0.243454608033823 3560 3195
SGTC_1356 1502-0781 85.8 µM -0.695234554262542 0.264607106466461 no 2483 0.243454160407505 3651 567702
SGTC_2057 5236571 38.335 µM -0.6958460793749 0.26442330079537 no 2484 0.243262614153699 3658 54684039 YBR257W POP4
SGTC_674 0498-0004 451 µM -0.697218139897054 0.26401113813572 no 2485 0.242833144168352 3650 4231473
SGTC_3107 9121808 49.47 µM -0.697712092941622 0.263862836384968 no 2486 0.242678631957408 3615 662681
SGTC_1389 3405-0187 19 µM -0.698067681994361 0.263756102577757 no 2487 0.24256743399762 3629 799890
SGTC_1045 1348-1485 165 µM -0.698651244001374 0.263580988012627 no 2488 0.242385005335665 3692 6810614
SGTC_871 0574-0004 149 µM -0.699367771003454 0.26336605464478 no 2489 0.242161111891562 3654 9551173
SGTC_2842 9000675 19.48 µM -0.701476414129991 0.262734054079631 no 2490 0.241502874416764 3644 2989072
SGTC_1256 0570-0116 285 µM -0.701525938012339 0.262719220157259 no 2491 0.241487426648537 3681 410638
SGTC_2126 5251174 33.877 µM -0.701698545342681 0.262667522314611 no 2492 0.241433590193253 3705 790722
SGTC_1457 k015-0032 57.3 µM -0.702404657955392 0.262456087834398 no 2493 0.241213420636189 3677 4302660
SGTC_3142 9086498 49.47 µM -0.703904320304648 0.262007326403628 no 2494 0.24074618039388 3646 25236367
SGTC_45 0kpi-0036 14.9 µM -0.703969660457783 0.261987782855119 no 2495 0.240725833982054 3663 2795021
SGTC_3036 9090181 49.47 µM -0.704287641051133 0.261892684027082 no 2496 0.240626830676404 3698 25236586
SGTC_3183 9108214 49.47 µM -0.70571888881235 0.261464858354061 no 2497 0.240181486004855 3594 4974831
SGTC_2521 angolensin 13.4 µM -0.70704115619103 0.261069928030964 no 2498 0.239770451026926 3699 821428 A flavenoid.
SGTC_1487 3970-0795 2.82 µM -0.708429104486836 0.260655710482399 no 2499 0.239339411925357 3750 3765103
SGTC_1998 st075797 76.8 µM -0.709818835486145 0.260241300077209 no 2500 0.238908243623209 3675 24208315
SGTC_2391 6285546 200 µM -0.710539607584857 0.26002650345205 no 2501 0.238684789262741 3684 846083
SGTC_1184 1269-1718 139 µM -0.713123661823816 0.259257183901531 no 2502 0.237884619389675 3719 5403821
SGTC_1116 jasmonic acid 1.58368 µM -0.715033863734815 0.258689239465904 no 2503 0.237294059306233 3722 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2011 4012611 177 µM -0.71660859269019 0.258221523205649 no 2504 0.236807820513813 3730 2049887
SGTC_1385 3091-4834 14.1 µM -0.717097942303535 0.258076268933939 no 2505 0.236656832667117 3672 4072814
SGTC_1229 0139-0193 12.2 µM -0.717417667359356 0.257981387428349 no 2506 0.236558210750858 3729 3090752
SGTC_620 0109-0052 432 µM -0.720012807250829 0.257211924572652 no 2507 0.235758555069119 3691 493037
SGTC_2273 7815444 169.05 µM -0.720062522013725 0.257197195727232 no 2508 0.235743250731746 3658 2824616
SGTC_2603 homopterocarpin 100 µM -0.72028390406172 0.257131612848546 no 2509 0.235675106489344 3744 101795 A weak amylase inhibitor.
SGTC_1205 4161-2785 76 µM -0.722165655835778 0.256574508389969 no 2510 0.235096317934236 3752 3498106
SGTC_2355 9061122 103.12 µM -0.725190854381003 0.255680198838052 no 2511 0.234167476370037 3724 5302957
SGTC_1410 3909-8106 77.9 µM -0.726306582681847 0.255350778449136 no 2512 0.233825422412123 3727 1039210
SGTC_2710 st078562 53.7235 µM -0.726589637122322 0.255267241509788 no 2513 0.233738689164835 3698 17250908
SGTC_3151 9099821 49.47 µM -0.7275540093514 0.254982736757627 no 2514 0.233443321151913 3674 17174189
SGTC_1753 st043925 64 µM -0.728065070421994 0.254832033107705 no 2515 0.23328687729662 3737 670181
SGTC_2605 digitonin 300 nM -0.728174865240618 0.254799662475527 no 2516 0.233253274964882 3751 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2030 5175110 200 µM -0.730439388901952 0.25413249690455 no 2517 0.232560824547722 3745 2831986
SGTC_3325 9138760 55.175 µM -0.730902272987427 0.25399623658163 no 2518 0.232419423777801 3715 43844959
SGTC_403 arphamenine a 50 µM -0.730914965034582 0.253992500932634 no 2519 0.232415547313982 3686 5487158 An arginine aminopeptidase inhibitor.
SGTC_3046 9092212 49.47 µM -0.731096292772407 0.253939133905462 no 2520 0.232360169283604 3737 25236637
SGTC_551 k048-0028 34.9 µM -0.731493702044097 0.253822191957197 no 2521 0.232238824986232 3707 6836383
SGTC_1827 berberine 7.24 µM -0.731605131531819 0.253789407708552 no 2522 0.232204807619321 3665 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2783 7738165 71.43 µM -0.732478190170552 0.253532617555549 no 2523 0.231938374919489 3709 17201110
SGTC_2957 9076800 11.52 µM -0.732711547540379 0.253464003970305 no 2524 0.231867189721783 3693 16459615
SGTC_163 TUB2.036 7.546 µM -0.735300067827261 0.252703561615905 no 2525 0.231078383454345 3778 15992207 YJR013W GPI14
SGTC_2310 7668677 200 µM -0.735389095119011 0.252677429018466 no 2526 0.23105128061185 3729 2197143
SGTC_2868 9035608 32.47 µM -0.736119125417272 0.252463193507444 no 2527 0.230829102261571 3712 6462614
SGTC_2674 ligustilide 100 µM -0.736564295934452 0.252332600265577 no 2528 0.230693677083152 3731 5319022 A signalling regulator.
SGTC_1941 st076221 61.8 µM -0.736666287254034 0.25230268556082 no 2529 0.230662656587682 3715 2828568
SGTC_3017 9080681 49.47 µM -0.736867328204159 0.252243724443149 no 2530 0.230601517131559 3751 16451914
SGTC_685 1278-0033 54.9 µM -0.738652291053739 0.25172055085708 no 2531 0.230059081449819 3767 3590572
SGTC_2906 7926292 26.41 µM -0.739105203019336 0.251587893316449 no 2532 0.229921558840957 3712 2966319
SGTC_2919 7978188 46.38 µM -0.741848739116024 0.250785103970218 no 2533 0.229089493338721 3709 2980291
SGTC_1833 st055984 71 µM -0.742251210549939 0.250667450509079 no 2534 0.228967573166576 3787 676288
SGTC_2084 5306078 60.6385 µM -0.745849518755621 0.249616866525306 no 2535 0.227879161392622 3680 679340
SGTC_869 0564-0080 44.1 µM -0.746493292137086 0.249429153497317 no 2536 0.227684741085315 3778 6843321
SGTC_1851 st056236 18.9 µM -0.747105697042071 0.249250656620344 no 2537 0.227499880787933 3732 5393171
SGTC_2075 5212009 200 µM -0.7471470304355 0.2492386116762 no 2538 0.227487406952366 3643 780898
SGTC_115 0527-0192 112.043 µM -0.747911162058283 0.249015992214718 no 2539 0.22725687219629 3794 4233931
SGTC_993 3909-8757 62.7 µM -0.748501661517307 0.248844030645428 no 2540 0.2270788116282 3734 4288324 YLR208W SEC13
SGTC_1320 1313-0481 95.3 µM -0.749108297017495 0.248667435890848 no 2541 0.226895967299434 3748 6813365 YLR208W SEC13
SGTC_2299 7976368 114.88 µM -0.749283602237004 0.248616416062163 no 2542 0.226843144508346 3788 2979718
SGTC_3054 9094397 49.47 µM -0.749759636185151 0.248477901997199 no 2543 0.226699741442854 3765 2598354
SGTC_2226 7298446 200 µM -0.752433843342577 0.247700539087632 no 2544 0.225895100289074 3740 3283010
SGTC_2397 5161689 200 µM -0.753202060391295 0.247477467127151 no 2545 0.225664250708851 3778 2259942
SGTC_1378 2093-0007 380 nM -0.753433077938695 0.24741040612634 no 2546 0.225594855942197 3810 3618014
SGTC_48 0382-0018 55 µM -0.753771435764921 0.247312203351348 no 2547 0.225493239304668 3825 762596
SGTC_750 4073-0104 132 µM -0.753814949534539 0.247299575710248 no 2548 0.225480172999277 3624 22330957
SGTC_1967 st070177 51.4 µM -0.754659367908685 0.247054594825838 no 2549 0.225226696101987 3797 5729214
SGTC_186 3455-3465 67.277 µM -0.755149208209955 0.24691254291039 no 2550 0.225079730193822 3713 755278
SGTC_564 3555-0129 330 µM -0.75574158306555 0.24674081475728 no 2551 0.224902073638119 3657 563260
SGTC_2626 ethyl orsellinate 100 µM -0.756385332712687 0.246554265701869 no 2552 0.224709099653121 3769 75653 A natural product.
SGTC_1892 st058411 7.36 µM -0.756623731631646 0.246485200423968 no 2553 0.224637659697684 3735 3934738
SGTC_394 menadione 8.33 µM -0.757439759024352 0.246248871975963 no 2554 0.224393221905676 3718 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3252 9135871 49.47 µM -0.759267595186843 0.245719956267156 no 2555 0.223846248939506 3780 17682838
SGTC_2485 5633444 17.78 µM -0.760419585570977 0.245386921745395 no 2556 0.223501909884624 3793 5724239
SGTC_1140 3229-1848 2.98 µM -0.761171805470473 0.245169589808394 no 2557 0.223277228099583 3806 2849525
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.762303652362805 0.244842770898477 no 2558 0.222939397273359 3792 165506
SGTC_495 decylubiquinone 155 µM -0.76333130635954 0.244546240731673 no 2559 0.222632918038055 3774 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_162 k030-0015 37.8 µM -0.764157630774933 0.244307944717846 no 2560 0.222386656015989 3837 1809920 YMR134W ERG29
SGTC_3216 9129716 49.47 µM -0.765808895794387 0.243832126950235 no 2561 0.22189501014903 3773 8056934
SGTC_76 0433-0009 400.328 µM -0.766443268092417 0.243649463430546 no 2562 0.22170629799188 3859 2841569
SGTC_1512 0259-0544 12.2 µM -0.766533496926372 0.243623488607864 no 2563 0.221679464299151 3749 18476
SGTC_161 4065-0411 162.148 µM -0.768466503005065 0.243067379595694 no 2564 0.221105041963744 3833 1906281 YLR208W SEC13
SGTC_188 3229-0966 278.469 µM -0.768499356738922 0.243057933799536 no 2565 0.221095286340494 3848 5722370
SGTC_1946 st076057 65.1 µM -0.769079172785458 0.242891263223379 no 2566 0.220923155672445 3671 953009
SGTC_1100 amiodarone 5.07 µM -0.769706916764124 0.242710885301125 no 2567 0.22073688310126 3864 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_918 glabranin 770.725 nM -0.770132371873354 0.242588674936731 no 2568 0.220610687540206 3822 124049 Also referred to as licorice root.
SGTC_2370 9071495 200 µM -0.77087880485457 0.242374345437005 no 2569 0.220389385633684 3784 21791103
SGTC_776 4476-4378 112 µM -0.771237875190874 0.242271279151094 no 2570 0.220282974067588 3850 2892008
SGTC_1164 k060-0068 93.7 µM -0.772157002801816 0.242007564251674 no 2571 0.220010722109215 3806 5963676
SGTC_3030 9087619 49.47 µM -0.774383162078552 0.241369483230725 no 2572 0.219352118957279 3812 25236973
SGTC_3168 9103419 49.47 µM -0.775479452140503 0.241055591304025 no 2573 0.219028201322776 3724 16649256
SGTC_707 0865-0008 204 µM -0.775646392332291 0.24100781214073 no 2574 0.218978900135747 3789 723043
SGTC_2245 6637752 200 µM -0.776845249360657 0.240664844275927 no 2575 0.218625038293321 3850 681890
SGTC_3020 9089140 49.47 µM -0.77782260490132 0.240385440030311 no 2576 0.218336799889036 3850 17217859
SGTC_3135 9127742 49.47 µM -0.777995213473977 0.240336113437404 no 2577 0.218285917504898 3872 3643468
SGTC_3226 9131256 49.47 µM -0.779199735472558 0.239992049056179 no 2578 0.21793103295859 3677 17178073
SGTC_2493 resveratrol 26.09 µM -0.781430549304249 0.23935554062765 no 2579 0.217274654678123 3700 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2045 5106652 78.05 µM -0.781589008023228 0.23931036339079 no 2580 0.217228074419781 3793 673349
SGTC_2052 5265182 7.135 µM -0.781621979926513 0.239300963550149 no 2581 0.21721838277961 3809 1239884
SGTC_2838 9002687 71.43 µM -0.781634938452828 0.23929726930597 no 2582 0.217214573866343 3799 6457060
SGTC_1591 genipin 88.4 µM -0.781891564569755 0.239224116206254 no 2583 0.217139151429416 3833 442424 A DNA cross-linking agent.
SGTC_1394 3474-0001 65.7 µM -0.782658980257264 0.239005431829971 no 2584 0.216913698189336 3807 5017666 YIL048W NEO1
SGTC_2094 5332512 191.667 µM -0.783727240223623 0.238701200287608 no 2585 0.216600087576911 3849 755774
SGTC_1887 st057648 70.8 µM -0.784854986222878 0.238380257673662 no 2586 0.216269298348627 3843 688672
SGTC_1132 3456-3614 2.5 µM -0.785816440874701 0.238106826246829 no 2587 0.215987516619663 3906 3125502
SGTC_972 1319-0219 195 µM -0.786387204536424 0.23794458612671 no 2588 0.215820338697853 3791 23903702
SGTC_1963 st076565 50.3 µM -0.786823565768138 0.237820590918318 no 2589 0.215692578141161 3824 4914280
SGTC_2589 lobaric acid 100 µM -0.787371581731615 0.237664918419611 no 2590 0.215532188745134 3836 73157 A novel microtubule depolymerizer.
SGTC_2893 9048488 25.97 µM -0.789746417222063 0.236990955823961 no 2591 0.214837938709865 3845 6467338
SGTC_1055 3448-0672 86 µM -0.790814349158206 0.23668822655077 no 2592 0.214526167631844 3843 748378
SGTC_847 0342-0274 5.54 µM -0.792690907648489 0.236156789601738 no 2593 0.213978964501075 3835 18097
SGTC_331 k048-0133 24.5 µM -0.792797619773635 0.236126588742651 no 2594 0.213947871755759 3794 6813582
SGTC_797 k781-0471 270 µM -0.792953279888011 0.236082538809184 no 2595 0.213902521736408 3799 23738129
SGTC_2675 theaflavin digallate 100 µM -0.793329264075939 0.235976158499503 no 2596 0.213793005587711 3790 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_543 3844-1095 191 µM -0.796662665792124 0.235034167894194 no 2597 0.212823486073839 3836 4230703
SGTC_673 1082-0474 110 µM -0.797412557505657 0.234822541551805 no 2598 0.212605734292751 3841 3098046
SGTC_1738 st035555 74 µM -0.797554190667066 0.234782583198802 no 2599 0.212564621803704 3874 5331140
SGTC_1278 0874-0585 172 µM -0.797921546217219 0.234678960281868 no 2600 0.212458009514124 3886 766306
SGTC_2380 9035439 200 µM -0.798011459483566 0.23465360158092 no 2601 0.212431920046456 3946 6462575
SGTC_1567 st069303 68.4 µM -0.798906944056237 0.234401126176008 no 2602 0.212172186080329 3908 5581319
SGTC_1209 2323-2347 50.3 µM -0.798911700807458 0.234399785445856 no 2603 0.212170806887623 3776 5412760
SGTC_2794 7785382 27.27 µM -0.801068285782719 0.233792371193603 no 2604 0.211546057479768 3766 2205081
SGTC_1456 k015-0012 13 µM -0.802019915235795 0.23352461708255 no 2605 0.211270719128445 3856 2989616
SGTC_509 pifithrin 175 µM -0.802348022992441 0.233432338869367 no 2606 0.211175835233485 3870 4817 A p53 inhibitor.
SGTC_430 0958-0115 16.4 µM -0.802784440329971 0.233309630630274 no 2607 0.211049668518451 3811 6833180
SGTC_1518 st038567 90.8 µM -0.804714391925243 0.232767412086431 no 2608 0.210492256291045 3814 77966
SGTC_3025 9087895 49.47 µM -0.804963622449781 0.232697442035158 no 2609 0.210420336116171 3855 17173641
SGTC_1749 st037932 54.2 µM -0.804965020811478 0.232697049486052 no 2610 0.210419932633193 3890 594497
SGTC_1381 2324-0066 62.1 µM -0.805806153669886 0.2324609927683 no 2611 0.210177314652941 3883 10885928
SGTC_309 k408-0051 1.48 µM -0.805971506290788 0.232414603642561 no 2612 0.210129639357274 3798 3640463
SGTC_3211 9128781 49.47 µM -0.806187994080273 0.232353876500292 no 2613 0.210067230117948 3898 17194361
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.807981080533626 0.231851236020213 no 2614 0.209550736782848 3846 75037 A free radical scavenger.
SGTC_644 1498-1197 63.3 µM -0.8104669304596 0.231155402067698 no 2615 0.208835931956728 3919 6741615
SGTC_558 k064-0027 21.3 µM -0.81138528561535 0.230898633069892 no 2616 0.208572223259559 3891 5088526
SGTC_854 0422-0053 192 µM -0.813698679873096 0.230252522273897 no 2617 0.207908795311028 3880 3596728
SGTC_895 0964-0006 13.7 µM -0.814474567727621 0.230036050231342 no 2618 0.207686567965863 3806 6738897
SGTC_1873 rapamycin 2 nM -0.815038334056762 0.229878831377202 no 2619 0.207525183858947 3824 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1608 st001473 40.5 µM -0.817432670507004 0.229211787758746 no 2620 0.206840605848923 3828 7292267
SGTC_825 1988-2224 89.6 µM -0.81997837716583 0.228503765622566 no 2621 0.206114216934365 3847 1180859
SGTC_1956 st077085 54 µM -0.822402241740472 0.22783077403311 no 2622 0.205424001962849 3899 24208685
SGTC_204 PMA1.184 62.41 µM -0.824209467694935 0.227329720271845 no 2623 0.204910274198143 3893 2252213 YGL008C PMA1
SGTC_1166 k206-0078 225 µM -0.824505715462434 0.227247644788514 no 2624 0.204826134801878 3890 5404595
SGTC_950 1165-0508 94.1 µM -0.826458526788095 0.226707036195899 no 2625 0.204272017517612 3893 6148369
SGTC_1727 st034309 9.9045 µM -0.827547032454332 0.226406013869019 no 2626 0.203963537910237 3995 870305
SGTC_1808 st050063 61.5 µM -0.828099925598008 0.226253199746735 no 2627 0.203806955828069 3839 4011993
SGTC_1005 4092-0690 4.4 µM -0.828881186567475 0.226037366424581 no 2628 0.203585821043635 3909 1529343
SGTC_3157 9099274 49.47 µM -0.829412611346718 0.225890620073692 no 2629 0.203435483833965 3837 17217662
SGTC_1924 st058459 75.1 µM -0.830955602826686 0.22546484757355 no 2630 0.202999355326964 3802 688683
SGTC_538 2922-0838 53.3 µM -0.831682854579887 0.225264327616471 no 2631 0.202793990439026 3867 777039
SGTC_1350 1495-0454 146 µM -0.83251989002419 0.22503366285471 no 2632 0.202557778009007 3892 1069057
SGTC_83 0170-0301 39.027 µM -0.83266460428695 0.224993797018258 no 2633 0.20251695614836 3803 3089716
SGTC_3212 9128307 49.47 µM -0.832767658036837 0.224965410246061 no 2634 0.202487889131655 3842 27243542
SGTC_3287 9117173 37.0625 µM -0.833273182252489 0.224826189980631 no 2635 0.202345338692649 3856 2789709
SGTC_1179 1021-1431 9.29 µM -0.833651905568143 0.224721922420206 no 2636 0.202238583589083 3916 2840958
SGTC_2442 5158906 48.48 µM -0.834175532012829 0.224577806283176 no 2637 0.202091038479546 3915 1893835
SGTC_465 cgp-37157 41 µM -0.834345641472006 0.224530998852883 no 2638 0.202043119665231 3830 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1379 2144-0755 36.5 µM -0.834773776928653 0.224413217320461 no 2639 0.201922546573024 3968 5392327
SGTC_1064 honokiol 6.76 µM -0.837515708948963 0.223659734352354 no 2640 0.201151375352526 3889 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2857 9024691 58.44 µM -0.837862464132004 0.223564548592336 no 2641 0.201053976057858 3965 16478292
SGTC_2820 7989630 71.43 µM -0.83867242939534 0.223342299497971 no 2642 0.200826576948542 3813 2984098
SGTC_592 k241-0073 46.5 µM -0.838772781647869 0.223314772262111 no 2643 0.20079841363525 3875 4230158
SGTC_1177 0983-0204 23.6 µM -0.840040974926446 0.222967065521488 no 2644 0.200442706391108 3937 766818
SGTC_1773 st048542 73.5835 µM -0.841349655108398 0.222608581800314 no 2645 0.200076040317325 3836 3237138
SGTC_3353 9151644 39.2805 µM -0.841415231900437 0.222590627151215 no 2646 0.200057677623221 3963 4909158
SGTC_2206 7254556 146.969 µM -0.841663471491269 0.222522667676762 no 2647 0.199988175201444 3908 4398905
SGTC_2991 9074669 71.4286 µM -0.842256350672595 0.222360405599686 no 2648 0.199822238922414 3870 17333109
SGTC_2067 5224629 34.075 µM -0.844675910626375 0.221698908798015 no 2649 0.199145906431922 3893 2835000
SGTC_3037 9091026 49.47 µM -0.844690530680493 0.221694915161561 no 2650 0.199141823927001 3888 25236398 YIL048W NEO1
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.845407197075896 0.2214991998667 no 2651 0.198941763766574 3913 1377
SGTC_759 3486-0358 89.3 µM -0.849809936478014 0.220299019760477 no 2652 0.197715382176956 3873 875103
SGTC_913 3487-1245 167 µM -0.851246968439936 0.21990809557356 no 2653 0.197316088472808 3861 4016153
SGTC_2889 9059656 51.95 µM -0.852108791321559 0.219673839961011 no 2654 0.197076856512004 4001 3949838
SGTC_1554 st069299 38.7 µM -0.852305922702645 0.219620277014578 no 2655 0.197022159822196 3859 24207999
SGTC_1798 st045719 60.953 µM -0.85255794463391 0.219551810576021 no 2656 0.19695224641209 3805 3980186
SGTC_3063 1327-0034 4 µM -0.852574153703797 0.219547407500768 no 2657 0.196947750367691 3807 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2428 5615643 7.78 µM -0.854137577913125 0.219122953187205 no 2658 0.19651438246676 3951 2253075
SGTC_3198 9112019 49.47 µM -0.859909873408103 0.217559924561828 no 2659 0.194919362747761 3967 45595555
SGTC_1553 gossypol 38.6 µM -0.860514625150537 0.217396542435867 no 2660 0.194752712559129 3782 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_618 k072-0232 33.2 µM -0.86115066646971 0.217224783453141 no 2661 0.194577533513483 3969 5872756 YGL099W LSG1
SGTC_2882 9058044 58.44 µM -0.861248256794791 0.217198436733584 no 2662 0.194550663590118 3913 18076804
SGTC_477 mead ethanolamide 10 µM -0.862169100590508 0.216949924985177 no 2663 0.194297235287482 3771 16061185
SGTC_2568 diosmetin 100 µM -0.862839429509838 0.216769124084299 no 2664 0.194112878457188 3957 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_741 4582-0002 126 µM -0.863697909036152 0.216537702553476 no 2665 0.193876931294476 3880 2912688
SGTC_2218 6965428 192.983 µM -0.865593275948211 0.216027272327136 no 2666 0.193356622147352 3831 675684
SGTC_1718 roemerine 11.9335 µM -0.866633161844696 0.215747523070479 no 2667 0.193071518818265 3747 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1558 st069300 45.6 µM -0.867665472022429 0.215470019646074 no 2668 0.19278874652748 3843 24208000
SGTC_1345 1488-0192 31.4 µM -0.868064419590168 0.215362830902897 no 2669 0.192679533901172 3932 658348
SGTC_951 1171-0579 82.7 µM -0.86980698521855 0.214895003347228 no 2670 0.192202946745867 3891 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1817 st052116 64.4 µM -0.875577660247495 0.213349967500164 no 2671 0.190629837214162 3929 4361398
SGTC_1006 4099-6547 255 µM -0.876383748406028 0.213134662790793 no 2672 0.190410725112699 3975 3146833
SGTC_1154 4088-0362 150 µM -0.876596895181469 0.21307775286062 no 2673 0.190352813099829 3929 6618304
SGTC_3204 9114183 49.47 µM -0.87703115404125 0.212961833704712 no 2674 0.190234858375878 3951 17027248
SGTC_1307 1187-1599 12.2 µM -0.878172846394965 0.212657250959048 no 2675 0.189924962678653 3936 1538471
SGTC_607 4491-0986 66.8 µM -0.87897170070599 0.21244428251467 no 2676 0.189708310017608 3954 698981 YDR232W HEM1
SGTC_1919 st067113 52.3 µM -0.87909585725499 0.212411194520676 no 2677 0.18967465189084 4003 1268243
SGTC_1371 2421-0008 32.7 µM -0.881015185621296 0.211900072464752 no 2678 0.189154800405128 3929 2827552
SGTC_1480 1070-0044 41.2 µM -0.882215789564438 0.211580714685279 no 2679 0.188830062466441 3955 3124987
SGTC_2247 cerulenin 830 nM -0.884385129546441 0.211004390504232 no 2680 0.188244173779631 3966 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1916 st067606 49.2 µM -0.885188841942879 0.210791103707508 no 2681 0.18802739466175 3933 19590279
SGTC_111 0083-0039 52.457 µM -0.885303379958609 0.210760718248422 no 2682 0.187996513760472 3849 759313
SGTC_2060 5238662 140 µM -0.885825747982836 0.210622173326245 no 2683 0.187855716423135 3946 790130
SGTC_1483 3453-0561 55.9 µM -0.885977013744917 0.210582063883982 no 2684 0.187814956914962 3960 4546991
SGTC_2352 9027995 87.8 µM -0.887416233369195 0.210200666442092 no 2685 0.187427423407734 3914 2997347
SGTC_519 k048-0011 62.8 µM -0.88976318564975 0.20957958816128 no 2686 0.186796529038651 4028 6836379
SGTC_3349 9149703 23.001 µM -0.889861103672297 0.209553699413072 no 2687 0.186770235867214 3949 4910494
SGTC_936 3005-4620 401 µM -0.890937714658902 0.20926917607794 no 2688 0.186481292902746 3960 777207
SGTC_743 1275-0778 158 µM -0.891618684765187 0.209089328917313 no 2689 0.186298675830963 3954 2849257 YMR203W TOM40
SGTC_2458 5808907 16.39 µM -0.892105048058695 0.208960933994899 no 2690 0.186168314699618 4089 2731747
SGTC_1035 k081-0041 55.2 µM -0.893108559298106 0.208696164129516 no 2691 0.185899519869933 3943 731709
SGTC_1374 2889-5571 141 µM -0.895045283795143 0.208185731473146 no 2692 0.185381440690758 3998 2853281
SGTC_1315 1237-0019 3.69 µM -0.895858735595017 0.207971562386001 no 2693 0.185164107637386 3995 825140
SGTC_3193 9111931 49.47 µM -0.898145103233154 0.207370294717285 no 2694 0.184554097939309 3983 17087244
SGTC_2327 6189656 200 µM -0.898946333390186 0.207159831087459 no 2695 0.184340623415184 4061 5349088
SGTC_2833 9001315 45.46 µM -0.899035779897669 0.20713634351275 no 2696 0.184316801409272 3953 2989378
SGTC_1 0258-0098 57.368 µM -0.899502420679977 0.207013834816108 no 2697 0.184192553508877 3899 6790032 YDR047W HEM12
SGTC_2445 5742597 35.57 µM -0.899694388781771 0.206963449265396 no 2698 0.184141455167243 3932 1774255
SGTC_1824 st053723 68.6 µM -0.90149135534193 0.206492154438502 no 2699 0.183663564030727 4009 675225
SGTC_1744 st037937 38.9 µM -0.901848310458376 0.206398610693417 no 2700 0.183568726305868 4054 1016152
SGTC_3290 9121031 71.43 µM -0.902454764764381 0.206239740712008 no 2701 0.183407670302644 3993 17014854
SGTC_2353 9059630 146.67 µM -0.905218407660732 0.205516680522308 no 2702 0.182674845910045 4029 4779114
SGTC_3087 9117406 49.47 µM -0.907491916458799 0.204922985533923 no 2703 0.182073361130132 4003 42546093
SGTC_435 c-PAF 6.7 µM -0.908975147869625 0.204536210639269 no 2704 0.181681622150938 3986 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2676 harmalol 100 µM -0.909243613173398 0.204466250733367 no 2705 0.181610773691879 3924 5459187 A monoamine oxidase inhibitor
SGTC_3195 9113082 49.47 µM -0.911286369617281 0.203934391414931 no 2706 0.181072253155312 3902 17018038
SGTC_2518 prenyletin 46.28 µM -0.911329745466822 0.203923106870768 no 2707 0.181060829078801 3933 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_25 0118-0223 35.662 µM -0.911746314199875 0.203814752419148 no 2708 0.180951138646231 3973 5333628
SGTC_2367 9070478 135.38 µM -0.912075162030991 0.20372923945476 no 2709 0.180864576207095 3926 572802
SGTC_813 k007-0158 173 µM -0.915351480631525 0.202878440540435 no 2710 0.180003570554717 3986 6523916
SGTC_2787 5284540 71.43 µM -0.916346684323671 0.202620425532188 no 2711 0.17974254478914 4046 736958
SGTC_536 3852-0578 10.6 µM -0.916941621062244 0.202466276840026 no 2712 0.179586616176493 4053 2869208
SGTC_1216 1165-0504 9.65 µM -0.919668218913784 0.20176071019124 no 2713 0.178873082697514 4037 6304004
SGTC_1708 st033234 31.827 µM -0.920305797369428 0.201595935526302 no 2714 0.178706490190343 4089 674664
SGTC_512 prima-1 270 µM -0.921348836431177 0.201326548213663 no 2715 0.178434165820557 4006 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1343 1487-0095 224 µM -0.921607341634128 0.201259817056885 no 2716 0.178366713812496 4010 4560101 YGL055W OLE1
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.921769748378393 0.201217899771522 no 2717 0.178324345084824 4076 4213774
SGTC_1240 0356-0016 42.1 µM -0.921837146653884 0.201200505770223 no 2718 0.178306764061497 3982 4305613
SGTC_1472 k841-0093 193 µM -0.923425486801172 0.200790851412331 no 2719 0.177892757428566 4090 X1472
SGTC_760 0568-0725 82.9 µM -0.924261626869649 0.20057540087528 no 2720 0.177675058260046 4027 3916171
SGTC_420 mitomycin C 81.9 mM -0.924505812699381 0.200512507032187 no 2721 0.177611513256736 3989 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2467 5474540 200 µM -0.925924235614375 0.200147404509076 no 2722 0.177242677683253 3957 5413519
SGTC_727 3032-0951 202 µM -0.926492647052989 0.200001207433594 no 2723 0.177095008289843 4010 3652836
SGTC_1870 st057514 26.5 µM -0.927485904641639 0.199745892867947 no 2724 0.176837153412143 3986 5393161
SGTC_1339 1486-1321 22.7 µM -0.928679785175907 0.199439268252092 no 2725 0.176527529984681 4010 3469382
SGTC_2415 st077333 57.7 µM -0.929275847018942 0.199286287658065 no 2726 0.176373074489381 4034 2766255
SGTC_550 4123-0385 25.7 µM -0.930206171176729 0.199047659166353 no 2727 0.176132173655273 4028 5731123
SGTC_2785 7756463 72.73 µM -0.930817627538562 0.198890914187595 no 2728 0.175973954859675 3965 2201551
SGTC_1525 8-methoxypsoralen 92.5 µM -0.930830054838247 0.198887729258709 no 2729 0.175970740138604 4084 4114 Related to psoralen; DNA damaging agent.
SGTC_2342 7990637 118.86 µM -0.935867702363604 0.197599189707912 no 2730 0.174670654057878 4087 2033102 YER133W GLC7
SGTC_2221 6807166 181.081 µM -0.936529261887021 0.197430350350523 no 2731 0.174500376869754 3946 674925
SGTC_71 0417-1750 47.813 µM -0.937134639446409 0.197275925891594 no 2732 0.174344652631188 4032 6811472
SGTC_3018 9082602 49.47 µM -0.937957688591808 0.197066093291746 no 2733 0.174133077329307 3976 17332089
SGTC_2208 7283366 200 µM -0.939185150264736 0.196753408624695 no 2734 0.17381784593945 3974 898663
SGTC_2285 7945142 200 µM -0.939598027897039 0.196648299382472 no 2735 0.173711894121157 4065 2970608
SGTC_1296 1068-0102 11.9 µM -0.942001316560613 0.196037152327694 no 2736 0.173095982930354 4035 767053
SGTC_2515 chrysin 20.77 µM -0.943073634235894 0.195764838190097 no 2737 0.172821620313177 4050 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1940 st075990 51.1 µM -0.944564575522925 0.195386596708453 no 2738 0.172440609734212 4133 1084979
SGTC_1192 1488-0095 21.4 µM -0.945038836631687 0.195266373077455 no 2739 0.172319524541933 4077 915875
SGTC_863 0466-0191 129 µM -0.945206759072906 0.195223816068371 no 2740 0.172276664707436 4059 765160 YPR165W RHO1
SGTC_270 tamoxifen 5.46 µM -0.945228235679576 0.195218373604163 no 2741 0.172271183597141 4042 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2663 amphotericin b 100 µM -0.945382537832852 0.195179274051019 no 2742 0.17223180694545 4001 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1568 digitonin 820 nM -0.945873001813102 0.195055024035183 no 2743 0.172106682679917 4006 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1635 st007035 42.4 µM -0.946876163915876 0.194801041186684 no 2744 0.171850942647613 3999 3716403
SGTC_2621 lithochol-11-enic acid 100 µM -0.94709997451974 0.194744403769904 no 2745 0.171793918863799 3943 6708711
SGTC_2700 st077718 96.8 µM -0.947318325999736 0.194689157491544 no 2746 0.171738297635217 4012 904970
SGTC_3313 9133968 57.047 µM -0.94751351998822 0.194639778487014 no 2747 0.171688585111985 4015 1494643
SGTC_3230 9131665 49.47 µM -0.948560008585809 0.194375174045939 no 2748 0.171422219391101 3986 15943720
SGTC_1703 st026983 48.3 µM -0.948957282476808 0.194274780796446 no 2749 0.171321169342281 4046 1104023
SGTC_425 3825-7017 13.1 µM -0.954367683274842 0.192910688677114 no 2750 0.16994877928686 4120 3397440
SGTC_1799 st045822 46.1415 µM -0.954468992991087 0.192885201985247 no 2751 0.169923148695659 4001 3674992
SGTC_1421 4029-0249 71.4 µM -0.956203678494492 0.192449122788546 no 2752 0.169484670928475 4104 2894095
SGTC_2858 9025781 8.96 µM -0.956553715709577 0.192361200761319 no 2753 0.169396279868071 3966 4894980 YPL153C RAD53
SGTC_3222 9128301 49.47 µM -0.959660689250514 0.191581871069948 no 2754 0.168613007003377 4054 4911358
SGTC_2719 novobiocin 32.65 µM -0.960490099509401 0.191374155604895 no 2755 0.168404305712395 4048 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1559 coumarin 343 70.1 µM -0.960553502942773 0.19135828268551 no 2756 0.168388358589734 4081 108770 A hepatotoxic, DNA x-linker.
SGTC_1529 apigenin 74 µM -0.961042671205013 0.19123584754282 no 2757 0.168265356479842 4075 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1188 1403-0014 4.57 µM -0.965388895748922 0.190150130182172 no 2758 0.167175030588447 4052 9614867
SGTC_2491 paeonol 100 µM -0.966635240155147 0.189839484783788 no 2759 0.166863205668777 3929 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1089 terbinafine 2.25 µM -0.96695944486136 0.189758729479265 no 2760 0.166782153902422 4053 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_392 N-ethylmaleimide 8.33 µM -0.967053457519818 0.189735316063341 no 2761 0.166758655318373 3995 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2460 5552655 174.22 µM -0.967209928540016 0.189696351622137 no 2762 0.166719549923675 4083 5401989
SGTC_237 nikkomycin 200 µM -0.967811568933758 0.18954657687454 no 2763 0.166569242474796 4072 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2738 aclarubicin 5.55 µM -0.968253474723924 0.189436613454028 no 2764 0.166458897157193 4007 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_729 4092-0585 94.1 µM -0.969013900778754 0.189247481680049 no 2765 0.166269126793426 4071 2169061
SGTC_429 1112-0049 25.5 µM -0.969890696246306 0.189029551079534 no 2766 0.166050489025603 4016 2836170
SGTC_85 0868-0259 160.055 µM -0.969940795911298 0.189017103301923 no 2767 0.166038001783257 3978 83173
SGTC_2462 5162487 171.77 µM -0.970310405489071 0.188925285600656 no 2768 0.165945896078779 3945 2259986
SGTC_2179 6298986 200 µM -0.972184450071935 0.188460162060393 no 2769 0.165479397521214 4035 738374
SGTC_912 3474-0017 2.18 µM -0.972652502367367 0.188344105367014 no 2770 0.165363019621543 4107 3360550
SGTC_1556 plumbagin 1.48 µM -0.973813155758824 0.188056503875237 no 2771 0.165074659884373 3972 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2363 9053361 176 µM -0.974950262289712 0.187775000164609 no 2772 0.164792466162891 4138 6469797 YMR079W SEC14
SGTC_2223 6903751 107.57 µM -0.975650290985399 0.187601829564784 no 2773 0.164618896769898 4031 5598863
SGTC_834 0312-0008 75.7 µM -0.975727747550495 0.187582674701129 no 2774 0.164599698997248 4053 6385573 YIL048W NEO1
SGTC_2413 inermin 26.06 µM -0.97572885494664 0.187582400852897 no 2775 0.164599424537303 4168 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_3233 9132340 49.47 µM -0.975905159209179 0.187538805683917 no 2776 0.164555732611624 4063 17682950
SGTC_542 3381-0244 89.3 µM -0.976765344700174 0.187326195402234 no 2777 0.164342668256578 4086 1112843
SGTC_740 k014-0057 261 µM -0.977307939160072 0.187192160119036 no 2778 0.164208361910382 4047 4012779
SGTC_2434 5670830 169.91 µM -0.97963565618975 0.186617825252822 no 2779 0.163632998891719 4103 1549830
SGTC_2473 5854593 8.94 µM -0.983574267953149 0.185648510544855 no 2780 0.162662441159098 3965 2872951
SGTC_1277 0873-0036 22 µM -0.983811190650202 0.185590302303083 no 2781 0.162604178016614 4141 5965735
SGTC_2598 perillyl alcohol 100 µM -0.987714842929124 0.184632866462909 no 2782 0.161646161554291 4121 10819 An apoptosis inducer.
SGTC_1443 4112-3303 14 µM -0.988075571311694 0.184544547093841 no 2783 0.16155781932256 4111 704433
SGTC_932 2857-0803 154 µM -0.988200424666204 0.18451398459387 no 2784 0.161527250121526 4143 674898
SGTC_2689 tacrolimus 100 µM -0.98895908926312 0.184328340919336 no 2785 0.161341579124044 4101 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1018 4259-0013 28.1 µM -0.991053452864654 0.183816457957603 no 2786 0.160829740048097 4145 6801262
SGTC_2492 derrusnin 100 µM -0.991824110679002 0.183628324709215 no 2787 0.160641666990448 4047 1715307 Part of coumarin class of compounds.
SGTC_897 1000-0139 31.4 µM -0.995519804947554 0.182727798847369 no 2788 0.159741758402215 4029 6151020
SGTC_1138 3761-0006 1.03 µM -0.995618441039639 0.18270380213342 no 2789 0.159717785604294 4100 12061087
SGTC_156 3474-0145 5.642 µM -0.996204839640158 0.182561180580518 no 2790 0.159575314210678 3906 2265471
SGTC_147 4466-0538 29.23 µM -0.997378965319886 0.182275823425764 no 2791 0.159290298739041 4177 6742687 YHR072W ERG7
SGTC_2551 apiole 73.87 µM -0.998790956248806 0.181933025357618 no 2792 0.15894798397867 3956 10659 A possible DNA adduct former.
SGTC_3091 9116372 49.47 µM -0.998977165306471 0.181887848302908 no 2793 0.158902876557066 4164 17169793
SGTC_442 cape 100 µM -1.00187928295342 0.181184658925122 no 2794 0.158200949757929 4066 5281787
SGTC_2909 7941780 10.49 µM -1.00193469347014 0.181171249424696 no 2795 0.15818756760339 4055 1243215
SGTC_3262 9137218 49.47 µM -1.00508730242435 0.180409333263306 no 2796 0.157427406843823 3975 17650664
SGTC_2549 cedrol 20.94 µM -1.00558465876476 0.180289317036083 no 2797 0.157307703325872 4049 6708665 A sedative which affects the nervous system.
SGTC_1121 fusaric acid 630.51 nM -1.00756739751071 0.179811363826639 no 2798 0.156831093494919 4060 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1751 st044839 27.194 µM -1.01018525654026 0.179181530821909 no 2799 0.156203270765471 4111 5291326
SGTC_1291 0993-0025 5.79 µM -1.01066894571515 0.179065311679929 no 2800 0.156087452474772 4114 4353356
SGTC_1925 st057770 10.1 µM -1.01319047529211 0.178460215698753 no 2801 0.155484594537933 4093 5989122
SGTC_2041 5107442 45.335 µM -1.01334185274327 0.178423930411395 no 2802 0.155448451523134 4151 793005
SGTC_3288 9119690 36.221 µM -1.01544134754755 0.177921159287186 no 2803 0.15494774590578 4111 17595618 YKL019W RAM2
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.0155309138006 0.177899730528584 no 2804 0.154926409089704 4116 77254
SGTC_2328 6201408 200 µM -1.01554328700339 0.177896770363285 no 2805 0.154923461650477 4108 2890418
SGTC_2826 7992541 19.48 µM -1.016806367602 0.177594754389062 no 2806 0.154622776181552 4125 2985066
SGTC_1514 1189-1591 158 µM -1.01700018695254 0.177548438778 no 2807 0.154576670237881 4133 767698 YMR146C TIF34
SGTC_1261 0712-0010 12.7 µM -1.01839588225726 0.177215144683839 no 2808 0.15424492914589 4146 2840123
SGTC_2761 levamisole 97.89 µM -1.02369764206729 0.175952681279978 no 2809 0.152989054729088 4084 26879 An alkaline phosphatase inhibitor.
SGTC_1995 st072814 61.1 µM -1.02421453895227 0.175829902402348 no 2810 0.152866976527559 4098 5769371
SGTC_504 lovastatin 124 µM -1.02459618595485 0.175739284357086 no 2811 0.152776882452921 4131 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2874 9043904 71.43 µM -1.02735864497572 0.175084250055494 no 2812 0.152125808544316 4067 4463428
SGTC_2092 5303694 80.6725 µM -1.0274203172849 0.175069644014077 no 2813 0.15211129427979 4111 1963699
SGTC_556 4058-0063 51.5 µM -1.02870013636019 0.174766715027574 no 2814 0.151810302921244 4144 6615692
SGTC_2800 7887935 81.82 µM -1.03237176077592 0.173899501437167 no 2815 0.150948997823718 4131 2961002
SGTC_3081 9117243 49.47 µM -1.03261682233229 0.173841717088065 no 2816 0.150891626266286 4101 45595589
SGTC_597 k018-0003 82.8 µM -1.03375325470407 0.173573911386197 no 2817 0.15062576491308 4187 6786234
SGTC_2497 7-hydroxyflavone 100 µM -1.03606195072517 0.173030665071465 no 2818 0.150086620878598 4148 5281894
SGTC_1111 tnp00062 510.699 nM -1.03635449539514 0.1729619054283 no 2819 0.150018395603478 4174 676306
SGTC_134 0269-0018 6.916 µM -1.03769179024013 0.172647809630771 no 2820 0.149706784155353 4105 4378915
SGTC_352 k048-0007 5.11 µM -1.03847873695325 0.172463146375583 no 2821 0.14952361473867 4109 6811911
SGTC_2087 5276107 200 µM -1.04089277350809 0.171897459935795 no 2822 0.148962657995428 4101 144405
SGTC_216 k038-0035 28.382 µM -1.04135771016367 0.171788646536655 no 2823 0.148854780988363 4065 4444231 YPR107C YTH1
SGTC_2131 toluylene red 5.2905 µM -1.04135998680387 0.171788113821879 no 2824 0.148854252879004 4113 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1090 efavirenz 20.7 µM -1.04161525637985 0.171728389566422 no 2825 0.148795046257728 4164 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2286 7945697 125 µM -1.04230943098486 0.171566043791109 no 2826 0.148634120644787 4169 1245733
SGTC_1105 epirubicin 18.1 µM -1.04279209360922 0.171453221883692 no 2827 0.148522296966369 4176 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3327 9140648 26.9345 µM -1.04504750593245 0.170926650157411 no 2828 0.148000506920859 4167 8029710
SGTC_1439 4092-1168 46 µM -1.04519104885188 0.170893172211012 no 2829 0.147967339821698 4146 2886240
SGTC_2645 abamectin 100 µM -1.04527752979684 0.170873004628236 no 2830 0.147947359892945 4098 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2647 atorvastatin 60.16 µM -1.04556333866367 0.170806364086004 no 2831 0.147881341537605 4111 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2079 5212404 121 µM -1.04606975217548 0.170688327174692 no 2832 0.147764414644176 4112 758462
SGTC_3012 9080433 71.4286 µM -1.047823400342 0.17027998334237 no 2833 0.147359989575132 4145 17688859
SGTC_1561 5-methoxyflavone 52.9 µM -1.04939276204903 0.169915082427929 no 2834 0.146998694039135 4063 94525
SGTC_2139 5578692 56.4705 µM -1.05099582881637 0.169542862556913 no 2835 0.146630252795336 4097 650991 YMR113W FOL3
SGTC_2788 5282734 71.43 µM -1.05467930214586 0.168689571927472 no 2836 0.145786010541491 4243 743706
SGTC_983 1491-0821 12.2 µM -1.0556477049878 0.168465696726356 no 2837 0.145564598673899 4143 46495113
SGTC_562 3772-2733 112 µM -1.05578328372955 0.168434368908853 no 2838 0.145533618530744 4142 2876874 YIL048W NEO1
SGTC_1104 tacrolimus 29.8 µM -1.05699203285884 0.168155232075773 no 2839 0.145257611770796 4195 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_602 3130-1533 38.1 µM -1.05753360267602 0.168030263786245 no 2840 0.145134063600072 4195 720941
SGTC_856 0433-0016 11.3 µM -1.05798142860525 0.167926972239369 no 2841 0.145031954628379 4193 3911780
SGTC_2920 7982904 15.77 µM -1.0582238340064 0.167871078218129 no 2842 0.144976703850818 4161 6456808
SGTC_1782 st039423 80.636 µM -1.05878754244173 0.167741144215686 no 2843 0.144848274175391 4181 2068169
SGTC_1795 st049545 62.3 µM -1.05884229652008 0.167728526929138 no 2844 0.144835803638588 4101 5291882
SGTC_1438 4092-1045 4 µM -1.05941681660776 0.167596173923464 no 2845 0.144704997179155 4156 1351342
SGTC_1058 3448-5425 97.3 µM -1.0608534128214 0.167265517726423 no 2846 0.14437826196484 4067 7279705
SGTC_1449 4112-4002 201 µM -1.06183452849387 0.167039939662316 no 2847 0.1441554058529 4211 2059539
SGTC_1785 bathophenanthroline 24 µM -1.06185646763074 0.167034897660572 no 2848 0.14415042512697 4066 72812 An iron chelator.
SGTC_2195 6536160 144.242 µM -1.06316189696776 0.166735063567284 no 2849 0.143854269271575 4106 3834386
SGTC_460 trequinsin 123 µM -1.0638918958166 0.166567547200195 no 2850 0.143688837360412 4214 5537 A vasodilator.
SGTC_80 0159-0065 512.242 µM -1.06451624739162 0.166424360441952 no 2851 0.14354744906874 4036 1548079
SGTC_328 k915-0120 63.5 µM -1.06493712627903 0.166327882303784 no 2852 0.143452191438064 4145 6624543
SGTC_1620 st003704 16.5 µM -1.06562869554612 0.166169432212467 no 2853 0.143295761075274 4137 2834414
SGTC_1976 st070609 63.5 µM -1.06588983767117 0.166109625551642 no 2854 0.143236721684607 4063 682556
SGTC_1677 st019204 53.9 µM -1.06711242586066 0.165829813896075 no 2855 0.142960535698712 4184 3945625
SGTC_261 5-fluorouridine 15.376 µM -1.07246060000118 0.164609370502077 no 2856 0.141756600808138 4198 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_468 gf-109203x 121 µM -1.07264767654797 0.164566785604124 no 2857 0.14171461241814 4145 2396 A protein kinase C inhibitor.
SGTC_715 0868-0130 184 µM -1.07339445959106 0.164396863871538 no 2858 0.141547084658057 4219 2876258
SGTC_2203 7227154 166.4 µM -1.07380815599036 0.164302781076885 no 2859 0.141454336860647 4174 896304
SGTC_109 0132-0036 33.701 µM -1.07822739348628 0.163299937439663 no 2860 0.140466144953001 3976 67274 A color developer.
SGTC_1266 0828-0227 32.9 µM -1.08044437812988 0.162798345189458 no 2861 0.139972171485459 4162 3913820
SGTC_2124 5246320 200 µM -1.08109959605467 0.162650294315367 no 2862 0.139826406546714 4189 579342
SGTC_1626 st003712 1.76 µM -1.0812714951011 0.162611467083878 no 2863 0.139788181623608 4205 24207035
SGTC_2307 7538926 6.34 µM -1.08143774344193 0.162573921926636 no 2864 0.139751219996837 4145 96582
SGTC_1752 st044819 83.042 µM -1.08193407823516 0.162461864333784 no 2865 0.139640910508115 4159 441209 YML126C ERG13
SGTC_987 1497-1013 404 µM -1.08291355078933 0.162240876150547 no 2866 0.13942339828802 4186 1676435
SGTC_1283 0922-0125 16.4 µM -1.08355463990935 0.162096339912851 no 2867 0.139281155994328 4172 3360884
SGTC_552 k242-0005 476 µM -1.08504639644394 0.161760341817694 no 2868 0.138950553323822 4256 4088318
SGTC_865 0488-0499 301 µM -1.08713397800872 0.161290904700948 no 2869 0.138488801725312 4145 9634651
SGTC_1699 st031318 29.054 µM -1.08732237362632 0.161248583698959 no 2870 0.138447182050211 4219 5340658
SGTC_3251 9135047 49.47 µM -1.0914928868697 0.160313579128372 no 2871 0.137528030058416 4211 17682963
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.0934423830274 0.159877731246423 no 2872 0.137099806681449 4074 17037758
SGTC_1912 st060209 90.8 µM -1.09410278215967 0.159730262059991 no 2873 0.136954951189643 4180 688787
SGTC_713 1488-1073 324 µM -1.09450836173372 0.159639739003259 no 2874 0.13686604104785 4148 3312542
SGTC_3343 9148379 18.9835 µM -1.09766540670456 0.158936252493535 no 2875 0.136175310325713 4220 1955036
SGTC_3334 9142812 21.919 µM -1.09989346487832 0.158440997402716 no 2876 0.135689271214489 4197 45283678
SGTC_1197 1601-0112 267 µM -1.10015925986425 0.158381983873095 no 2877 0.135631368877257 4154 7350313
SGTC_3110 9122132 49.47 µM -1.10033105129812 0.158343849295699 no 2878 0.135593953831628 4292 918317
SGTC_224 benfluorex 43.875 µM -1.10392848298007 0.157546668811383 no 2879 0.134812081069592 4231 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2405 ticlatone 3.52 µM -1.10675100445959 0.156923055686951 no 2880 0.134200798408897 4038 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_257 daunorubicin 18.5 µM -1.10787924654388 0.156674234733297 no 2881 0.13395698478231 4220 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2930 9013230 14.89 µM -1.10861362040119 0.156512416541573 no 2882 0.133798449901929 4217 2995857
SGTC_2968 9090663 33.37 µM -1.10878127521159 0.156475489487053 no 2883 0.133762275070331 4159 25236811
SGTC_3109 9122853 49.47 µM -1.11021505855436 0.156159923788766 no 2884 0.133453182652433 4231 1234709
SGTC_1793 st048256 72.231 µM -1.11031677493497 0.156137552663992 no 2885 0.133431273496645 4114 672022
SGTC_417 st075190 100 µM -1.11242070317804 0.155675296056843 no 2886 0.132978653578111 4210 222757
SGTC_1034 k072-0165 12.7 µM -1.11347017729539 0.155445052573659 no 2887 0.132753274860111 4232 5835461
SGTC_2043 5101342 149 µM -1.11661383802419 0.154756711959342 no 2888 0.132079736153792 4218 678451
SGTC_1878 temozolomide 1 mM -1.11838478270571 0.154369831418683 no 2889 0.131701345345259 4142 5394 DNA alkylating agent.
SGTC_1613 st002381 52.1 µM -1.11944263368208 0.154139038655264 no 2890 0.131475675677315 4187 551167
SGTC_3129 9127257 49.47 µM -1.12211123004865 0.153557842047257 no 2891 0.130907574810683 4157 837894
SGTC_1648 st011736 69.8 µM -1.12297669538075 0.153369663432621 no 2892 0.130723696107338 4201 2855514
SGTC_1503 4585-0012 61.3 µM -1.12312660504105 0.153337084019713 no 2893 0.130691864115699 4251 2922052
SGTC_716 1683-5115 658 µM -1.12313689168806 0.153334848621956 no 2894 0.130689680033591 4176 723597
SGTC_3302 9125395 16.351 µM -1.12366794890271 0.153219473571926 no 2895 0.130576959146749 4167 17599668
SGTC_2960 9079389 5.97 µM -1.12373989862032 0.153203846533046 no 2896 0.130561692450789 4221 16457355
SGTC_3086 9117350 49.47 µM -1.12599552445515 0.152714473971451 no 2897 0.130083706861397 4150 2679265
SGTC_1289 0976-0073 69.1 µM -1.12601154978368 0.1527110008867 no 2898 0.130080315301414 4273 3391136
SGTC_1071 trifluoperazine 6.31 µM -1.12631357705403 0.152645553911465 no 2899 0.130016406459643 4286 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_806 3966-4455 5.86 µM -1.12635690876964 0.152636165790092 no 2900 0.130007239270094 4197 714982
SGTC_1602 st001878 87.6 µM -1.12766088245838 0.152353829909733 no 2901 0.129731581943098 4211 595405 YLR310C CDC25
SGTC_1393 3470-5649 58.2 µM -1.13031990455623 0.151779174272847 no 2902 0.129170725153919 4204 4108395
SGTC_784 4579-0127 173 µM -1.13066141794645 0.151705472478506 no 2903 0.129098813107928 4256 1948547
SGTC_3303 9125618 40.5795 µM -1.13120029160486 0.151589226868559 no 2904 0.128985399621237 4226 22695467
SGTC_921 1561-0023 372 µM -1.13129225068015 0.151569395409625 no 2905 0.128966052453316 4189 24050882
SGTC_2545 solidagenone 89.61 µM -1.13164939496599 0.151492391720184 no 2906 0.128890932349342 4076 6708572 An anti ulcer agent
SGTC_1172 0370-0043 85 µM -1.13332863388446 0.151130680621531 no 2907 0.128538135723156 4243 376585
SGTC_587 k089-0003 57 µM -1.13382020413919 0.151024904312974 no 2908 0.128434987103579 4119 9659696
SGTC_809 3998-0021 90 µM -1.13495952850447 0.150779933444189 no 2909 0.128196137996464 4182 715485
SGTC_3305 9127027 53.8275 µM -1.13511805828037 0.150745868276106 no 2910 0.128162928118123 4164 41905295
SGTC_127 0180-0333 59.125 µM -1.13552591505668 0.150658250818805 no 2911 0.128077515013716 4133 771601
SGTC_2350 9023895 38.85 µM -1.13555292007601 0.150652450687645 no 2912 0.12807186103592 4242 2997209
SGTC_1780 st038448 24.544 µM -1.13681382285679 0.150381799872686 no 2913 0.127808061786415 4274 728868 YDL195W SEC31
SGTC_3019 9081971 49.47 µM -1.13726367294575 0.150285318710459 no 2914 0.127714038046396 4247 16451803
SGTC_2769 toremifene 3.73 µM -1.1376586736008 0.150200635347804 no 2915 0.12763151810883 4276 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2076 5212012 200 µM -1.13892175829024 0.149930058759762 no 2916 0.12736789476595 4187 604802
SGTC_2194 5927483 104.545 µM -1.14464332845448 0.148708463546279 no 2917 0.126178468020211 4272 760979
SGTC_1546 5-methoxyflavanone 78.7 µM -1.14506218666875 0.148619296485843 no 2918 0.126091698967484 4242 147795
SGTC_1643 st009866 20.2 µM -1.14519782275278 0.148590429769665 no 2919 0.126063610037451 4187 3156273 YOR207C RET1
SGTC_1716 st033144 30.6155 µM -1.14605091039267 0.148408957539721 no 2920 0.125887043786229 4264 674617
SGTC_859 0439-0102 54.6 µM -1.14674309354391 0.148261822531771 no 2921 0.125743907243345 4247 610143
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.14781264478114 0.148034663636161 no 2922 0.125522958076151 4266 688798
SGTC_901 1112-0062 60.1 µM -1.14968401370352 0.147637769612912 no 2923 0.125137020499621 4256 1908457
SGTC_2867 9039098 71.43 µM -1.14971291646816 0.147631645291012 no 2924 0.125131066308037 4206 6463460
SGTC_1268 0828-0275 2.46 µM -1.14990019847554 0.147591965484293 no 2925 0.125092489570158 4293 745337
SGTC_3331 9141060 1.957 µM -1.15112832388838 0.147331937179117 no 2926 0.124839723563536 4199 4906567 YPR165W RHO1
SGTC_1996 st072960 66.8 µM -1.15165067514778 0.147221434009264 no 2927 0.124732324350675 4271 1719405
SGTC_1137 ixabepilone 100 µM -1.15310806292745 0.146913418097984 no 2928 0.124433016300579 4194 154225 A novel microtubule stabilizer.
SGTC_3136 9095672 49.47 µM -1.15436534307004 0.146648042049122 no 2929 0.124175208757766 3999 17217380
SGTC_1084 voriconazole 435 nM -1.15715743224065 0.146059862519241 no 2930 0.123604022824244 4249 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2096 5468907 200 µM -1.15803939573871 0.145874398545343 no 2931 0.123423979933663 4256 759785
SGTC_3346 9158254 43.5805 µM -1.15901980117934 0.145668419501607 no 2932 0.123224056938887 4244 17639500
SGTC_1813 st051246 8.6015 µM -1.16243383925141 0.144952671133657 no 2933 0.122529642251084 4197 5291959
SGTC_2148 5546263 113.568 µM -1.16338009658423 0.144754709353679 no 2934 0.122337660614244 4243 792097
SGTC_2989 9073649 71.4286 µM -1.16411461149296 0.144601170728415 no 2935 0.122188784008131 4218 21367202
SGTC_2344 7990960 76.95 µM -1.16825530893103 0.143737676931507 no 2936 0.121351898260293 4229 140813
SGTC_431 k089-0097 107 µM -1.16958780501799 0.14346054204396 no 2937 0.121083443633981 4048 5499420
SGTC_2443 5493264 126.67 µM -1.17298234236961 0.142756171105882 no 2938 0.120401443372888 4306 5340055
SGTC_2351 9026858 72.31 µM -1.1741008002999 0.142524602544452 no 2939 0.120177326483306 4161 1409300
SGTC_22 0964-0034 14.468 µM -1.17677968073862 0.141970993286341 no 2940 0.119641727379331 4267 138402
SGTC_1829 berberine 14.4 µM -1.17716615215812 0.14189124660858 no 2941 0.119564597807049 4231 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3249 9135183 49.47 µM -1.17838423132818 0.141640099807773 no 2942 0.119321730620674 4248 4902779
SGTC_2687 chenodiol 100 µM -1.17884410186908 0.141545360831454 no 2943 0.119230129746922 4337 5702181 A cholesterol synthesis inhibitor.
SGTC_2399 5884133 200 µM -1.18024328697105 0.141257375618461 no 2944 0.118951733593592 4245 722445
SGTC_810 3825-7150 143 µM -1.18272933190172 0.140746669546349 no 2945 0.11845821774924 4330 22330411 YGL099W LSG1
SGTC_1972 st070201 17.4 µM -1.18351358159789 0.140585822095253 no 2946 0.118302833551364 4283 2829099
SGTC_817 1391-0715 46 µM -1.1841920429694 0.140446772236064 no 2947 0.118168525603812 4250 1353946
SGTC_2917 7979103 53.79 µM -1.18511684691212 0.140257385190595 no 2948 0.117985625492235 4307 2980565
SGTC_2876 9059903 25.97 µM -1.18931981228051 0.139398862093042 no 2949 0.117156920955496 4262 6916095
SGTC_733 4069-0007 56.1 µM -1.19127261986294 0.139001188713477 no 2950 0.116773289479465 4297 5717425 YNL287W SEC21
SGTC_3045 9092950 49.47 µM -1.1923533394075 0.138781441269611 no 2951 0.116561363991446 4252 44120432
SGTC_406 estrone 100 µM -1.19823071715973 0.137590511595788 no 2952 0.115413605078892 4270 5870 A steroid.
SGTC_2669 eugenol 100 µM -1.19924158405557 0.137386385392574 no 2953 0.115217011045079 4289 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_896 0964-0007 44.5 µM -1.20145916177577 0.136939310558402 no 2954 0.114786569379683 4251 6756758
SGTC_220 paclitaxel 373.376 µM -1.20151515680964 0.136928034562023 no 2955 0.114775715324324 4244 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_779 1360-0071 233 µM -1.20186745761107 0.136857104566224 no 2956 0.114707442224869 4332 7566
SGTC_668 1682-0499 62.6 µM -1.20552016405297 0.136123171957272 no 2957 0.114001279299067 4259 682214
SGTC_850 0388-0143 75.9 µM -1.20886576227215 0.13545331384319 no 2958 0.113357210821995 4272 67273
SGTC_408 cantharidin 100 µM -1.20904752649781 0.135416985687442 no 2959 0.113322293474546 4264 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_529 4076-0302 30.3 µM -1.21111327951893 0.135004584839502 no 2960 0.112925996305568 4259 5816522
SGTC_2482 5981709 142.65 µM -1.21324988813746 0.134578945667464 no 2961 0.112517147854024 4220 877755
SGTC_1424 4048-1941 275 µM -1.21464558712967 0.134301402849428 no 2962 0.11225064696252 4367 X1424
SGTC_1985 st071382 65.5 µM -1.21623773597085 0.133985275111378 no 2963 0.111947186249378 4290 6123237
SGTC_617 3770-0098 35 µM -1.22565997447965 0.132124919920949 no 2964 0.110163329162957 4221 5962639
SGTC_1327 1436-0082 2.18 µM -1.23033475465054 0.131208558361288 no 2965 0.109285887401875 4315 15992205
SGTC_1218 1348-1416 30.7 µM -1.23082077447264 0.131113540117028 no 2966 0.109194951938266 4267 6787668
SGTC_1731 st035964 63 µM -1.23098120672476 0.131082185597244 no 2967 0.109164946621504 4223 6739575
SGTC_1219 1469-0211 33.1 µM -1.23129873781231 0.131020143305896 no 2968 0.109105576898638 4322 6822282
SGTC_1898 st060199 18.6 µM -1.23560223262762 0.130181285460527 no 2969 0.108303227205872 4292 688866
SGTC_1391 3442-0225 151 µM -1.23771225131578 0.129771351196486 no 2970 0.107911387406455 4278 5227075
SGTC_2576 guaiol 23.12 µM -1.23832231445805 0.129652994945934 no 2971 0.107798286483634 4224 227829
SGTC_470 aa-861 153 µM -1.23896509622249 0.129528371979686 no 2972 0.107679212188623 4267 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_106 0092-0003 11.579 µM -1.24067682690466 0.129196905316043 no 2973 0.107362579067659 4238 1072148
SGTC_1679 SEC14.276 6.7 µM -1.24685351154762 0.128005717610899 no 2974 0.106225607622633 4318 1005053 YMR079W SEC14
SGTC_920 mycophenolic acid 780.421 nM -1.24963038213055 0.12747268564266 no 2975 0.105717299629167 4300 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_670 4204-0025 119 µM -1.25394670652928 0.126647216812571 no 2976 0.104930688418059 4344 719039
SGTC_2744 captopril 92.04 µM -1.25796078937641 0.125882897263677 no 2977 0.104202968595754 4395 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2965 9082772 38.63 µM -1.25807156109298 0.125861850985446 no 2978 0.104182938606873 4340 16459634
SGTC_1562 morin hydrate 59.1 µM -1.27281510439545 0.123082498239153 no 2979 0.101541830032033 4369 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_11 0438-0307 1.3 µM -1.27401627827597 0.122857971335142 no 2980 0.101328823606074 4330 4011476
SGTC_1701 st028638 40.4 µM -1.27420463597284 0.122822789035355 no 2981 0.101295451328677 4348 3490878
SGTC_2814 7977482 42.97 µM -1.27704001564834 0.122294037580012 no 2982 0.100794060121325 4355 6456762
SGTC_2015 5119600 184 µM -1.27734083324145 0.122238033965028 no 2983 0.100740971752728 4374 2828786
SGTC_1709 st033179 39.1045 µM -1.28100997511715 0.121556393708453 no 2984 0.100095081204937 4344 573381
SGTC_2952 9073731 13.78 µM -1.2820784698615 0.121358395773382 no 2985 0.0999075603892435 4366 16457353
SGTC_1226 3909-7979 35.4 µM -1.28249206457923 0.121281815314722 no 2986 0.0998350434434382 4349 6615510
SGTC_866 0495-0101 262 µM -1.28486966087923 0.120842243021531 no 2987 0.0994189172187164 4339 635694
SGTC_3310 9130229 44.1445 µM -1.28538961960147 0.120746262156433 no 2988 0.0993280833875519 4380 7761258
SGTC_1176 0848-0131 83.3 µM -1.28751016401602 0.120355379724965 no 2989 0.0989582646224982 4408 6769040
SGTC_2916 7875993 68.79 µM -1.28782030221379 0.120298286386293 no 2990 0.0989042616770427 4208 1299250
SGTC_64 000l-0018 272.079 µM -1.29617753619885 0.118766982707247 no 2991 0.0974571634622297 4279 6811119
SGTC_367 0335-0881 7.1 µM -1.29765469800256 0.11849775937411 no 2992 0.0972030086325906 4303 23828853
SGTC_1775 st081588 35.1725 µM -1.29911647214262 0.118231765436039 no 2993 0.0969519804772513 4353 1426443 YGL099W LSG1
SGTC_1361 1608-0041 5.61 µM -1.2993035789993 0.118197748757066 no 2994 0.0969198833028209 4332 X1361
SGTC_3011 9081274 71.4286 µM -1.30375129941693 0.117391174501131 no 2995 0.0961591961452271 4352 6625322
SGTC_10 0279-0212 42.575 µM -1.30441781110335 0.117270642191695 no 2996 0.0960455828096988 4359 39851 YBR002C RER2
SGTC_659 k018-0002 107 µM -1.30643107834933 0.11690709429734 no 2997 0.095703001417081 4340 6797879 YHR007C ERG11
SGTC_3268 9137683 49.47 µM -1.30643396126662 0.116906574284838 no 2998 0.0957025114998267 4450 1953228
SGTC_2162 5663267 200 µM -1.31776436450963 0.114875477188728 no 2999 0.09379127027832 4384 6456493
SGTC_1981 st071826 47 µM -1.31778567529307 0.114871680800785 no 3000 0.0937877022641901 4417 11838600
SGTC_2186 6124449 200 µM -1.32030143766717 0.114424139828877 no 3001 0.0933671978918074 4387 3834182 YLR033W RSC58
SGTC_236 1509-0011 5.31 µM -1.3203684593229 0.114412234025587 no 3002 0.0933560144411469 4418 3107280
SGTC_2227 7312221 64.1025 µM -1.32408655166837 0.113753128892542 no 3003 0.0927371507037246 4497 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_284 0988-0104 32.6 µM -1.3249024193462 0.113608863073027 no 3004 0.0926017591675226 4350 4666532
SGTC_861 0443-0273 110 µM -1.32519945022103 0.113556372985475 no 3005 0.09255250383833 4377 6149169
SGTC_357 1325-0123 420 µM -1.32793246605838 0.11307421693435 no 3006 0.0921002090909069 4404 1098503
SGTC_63 0099-0242 26.702 µM -1.32892396496181 0.112899659296675 no 3007 0.0919365282273245 4403 3898502 YLR359W ADE13
SGTC_2425 5628681 7.85 µM -1.329516442646 0.112795442918574 no 3008 0.0918388223698055 4450 5714958
SGTC_2308 7584454 197.62 µM -1.33024946774568 0.11266659943666 no 3009 0.0917180452224062 4416 893577
SGTC_2844 9010103 25.97 µM -1.33204317308126 0.112351764026526 no 3010 0.0914230010487669 4374 2480525
SGTC_180 1486-1293 102.781 µM -1.33721731380104 0.111447110042384 no 3011 0.0905758559790323 4340 4140536
SGTC_1745 st081495 74 µM -1.33750496332026 0.111396970407874 no 3012 0.0905289316232386 4248 13842402 YBL026W LSM2
SGTC_1779 st039427 55 µM -1.33971730458489 0.111011881012763 no 3013 0.0901686347376333 4381 1124498
SGTC_935 2996-0153 430 µM -1.34126701815104 0.110742699841607 no 3014 0.0899168870551319 4402 23738523
SGTC_426 0988-0037 14.6 µM -1.34138088882742 0.11072293926659 no 3015 0.0898984096271165 4425 5383008
SGTC_683 panaxydol 45 µM -1.34265002198974 0.110502870939927 no 3016 0.0896926624383065 4405 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1758 st042942 75.2445 µM -1.34409629221428 0.110252469426454 no 3017 0.0894586254716952 4372 669317
SGTC_2763 lisinopril 49.32 µM -1.34453832231535 0.110176019338469 no 3018 0.0893871863998939 4308 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2678 equilin 100 µM -1.34543351673558 0.110021309970777 no 3019 0.089242638801214 4392 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2008 4012253 172 µM -1.34547538329432 0.110014078321972 no 3020 0.0892358828416357 4385 603940
SGTC_992 3909-8734 162 µM -1.35038105206645 0.109169077519785 no 3021 0.0884468927571206 4410 4288319
SGTC_1816 st051957 91.6 µM -1.3573419444156 0.107978083770764 no 3022 0.0873362928264168 4398 674121
SGTC_573 3702-0553 84.7 µM -1.35996758044419 0.107531282088213 no 3023 0.086920091637591 4351 1222756
SGTC_2437 5741531 144.16 µM -1.36001153698957 0.10752381340608 no 3024 0.0869131365236495 4425 2262990
SGTC_533 1222-0222 6.71 µM -1.36320677259489 0.106981909923377 no 3025 0.0864086767049438 4425 3982874
SGTC_3258 9138477 49.47 µM -1.36380953497652 0.106879904285489 no 3026 0.0863137592806323 4438 4970355
SGTC_55 0767-0285 6.563 µM -1.36704498694048 0.106333567009245 no 3027 0.0858056025376512 4332 3116166
SGTC_3078 9116413 49.47 µM -1.37293843804974 0.105343589086684 no 3028 0.0848857428715315 4357 17177322
SGTC_2048 5246248 200 µM -1.37450907714568 0.105080883057453 no 3029 0.0846418471020253 4429 677046
SGTC_2106 5357045 167.29 µM -1.37573772652503 0.104875709212371 no 3030 0.0844514236823701 4441 668842
SGTC_2998 9066762 71.4286 µM -1.37623284416142 0.104793110884143 no 3031 0.084374778319443 4449 4945196
SGTC_2456 5770359 74.46 µM -1.38016307611113 0.104139117984231 no 3032 0.0837682199519029 4419 3118787
SGTC_2651 TUB2.036 5 µM -1.38589109442113 0.103191278767159 no 3033 0.0828900802800468 4346 15992207 YFL037W TUB2
SGTC_362 0310-0100 9.03 µM -1.38892842154965 0.102691228492058 no 3034 0.0824272584898297 4465 790235
SGTC_514 4466-0038 2.65 nM -1.39036731819101 0.102454951532796 no 3035 0.0822086826989085 4222 5722064
SGTC_3229 9132204 49.47 µM -1.39483957952922 0.101723098770771 no 3036 0.0815321102614783 4522 17682924
SGTC_3293 9120939 62.045 µM -1.39611422946487 0.101515210310734 no 3037 0.0813400497483237 4420 934087
SGTC_2013 4024628 200 µM -1.39926298877495 0.101002991474475 no 3038 0.0808670669970869 4455 5230760
SGTC_291 SEC14.278 35.5 µM -1.40008931007041 0.100868883741052 no 3039 0.080743287899244 4449 1068044
SGTC_2243 6634756 200 µM -1.40075459069601 0.100761006465833 no 3040 0.0806437359500883 4469 885676
SGTC_496 calpeptin 138 µM -1.40217632672094 0.100530749726529 no 3041 0.0804312995205122 4433 73364 A calpain inhibitor.
SGTC_2123 5259487 200 µM -1.40459072957964 0.100140605887967 no 3042 0.080071507439894 4451 2173474
SGTC_2036 5160441 105 µM -1.4058684837702 0.0999345811667666 no 3043 0.0798815907148874 4407 134534 YIL048W NEO1
SGTC_58 0957-0393 9 µM -1.40791221230886 0.0996056947760854 no 3044 0.079578533218318 4051 6997992
SGTC_2792 7535235 81.82 µM -1.41287816401236 0.098809847759523 no 3045 0.0788457752673201 4419 1281891
SGTC_251 melphalan 456.522 µM -1.41300801741938 0.0987890999671342 no 3046 0.078826683378905 4481 460612 A DNA alkylator.
SGTC_807 1315-0151 48 µM -1.41309305799516 0.0987755140327751 no 3047 0.0788141820611292 4459 4011080
SGTC_2252 omeprazole 400 µM -1.41637366153075 0.0982524537998472 no 3048 0.0783330655991586 4472 4594 A proton pump inhibitor.
SGTC_1761 st044296 37 µM -1.41690810573956 0.0981674344205385 no 3049 0.0782548981642796 4458 1826700
SGTC_105 0111-0055 734.78 µM -1.41780075162362 0.0980255525260622 no 3050 0.078124472340127 4464 5179370
SGTC_875 0709-0210 25.7 µM -1.41909166178574 0.0978206342488283 no 3051 0.0779361472792425 4422 6251364
SGTC_2629 bisabolol 100 µM -1.41969485119912 0.097724992047865 no 3052 0.0778482688705456 4472 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.42076926304624 0.0975548022849178 no 3053 0.0776919245685164 4462 23847180
SGTC_1426 4048-4480 71.7 µM -1.42256062764162 0.0972715287420151 no 3054 0.0774317822273837 4462 14224343
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.42286042000802 0.0972241807411427 no 3055 0.0773883110131895 4457 5377381
SGTC_474 dl-dihydrosphingosine 5 µM -1.42692407993631 0.0965840500889945 no 3056 0.0768008895717436 4440 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_3064 1327-0027 10 µM -1.42819863987686 0.0963839134554406 no 3057 0.0766173460027997 4398 16000455 YPR107C YTH1
SGTC_2001 4023502 57.655 µM -1.42930263990962 0.0962108052930335 no 3058 0.076458633789863 4461 108941 YCR052W RSC6
SGTC_1233 0325-0408 14.2 µM -1.4304386290627 0.0960329198927442 no 3059 0.0762955840090139 4492 12874
SGTC_781 4335-2806 94.4 µM -1.43051381446363 0.0960211550924042 no 3060 0.0762848019081479 4511 845254
SGTC_1861 st057647 17.4 µM -1.4306620464738 0.0959979632683945 no 3061 0.0762635478204952 4493 688668
SGTC_3055 9094636 49.47 µM -1.43104790787945 0.0959376121582388 no 3062 0.076208242631223 4475 25236176
SGTC_883 0850-0245 24.6 µM -1.43317283218718 0.0956057607279878 no 3063 0.0759042257988952 4506 6823229 YPR165W RHO1
SGTC_2526 patulin 37.61 µM -1.43532089822459 0.0952711545439568 no 3064 0.0755978376269902 4472 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2870 9038528 12.99 µM -1.43745448195344 0.0949396586191287 no 3065 0.07529444880704 4475 6463316
SGTC_358 0075-0058 9.45 µM -1.44083725447448 0.0944158185481348 no 3066 0.0748153329277934 4429 1069125
SGTC_1079 idarubicin 2.36 µM -1.44087005148782 0.094410750211604 no 3067 0.0748106991647194 4479 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3352 9151559 45.5865 µM -1.4472340912556 0.0934310660858668 no 3068 0.0739156857164679 4476 17159339
SGTC_2231 micatex 6.853 µM -1.44892108112618 0.0931726333849512 no 3069 0.0736798115836606 4494 20737 An antifungal of unknown mechanism.
SGTC_2553 4-methylesculetin 85.09 µM -1.45525070279633 0.0922076972855589 no 3070 0.0727999343908359 4485 5319502
SGTC_154 3389-1638 511.116 µM -1.45904803038391 0.0916323648274518 no 3071 0.0722759442676344 4453 5238686
SGTC_605 1315-0399 119 µM -1.45973618994297 0.0915283872041346 no 3072 0.0721812958128668 4550 24020461
SGTC_2047 4141938 200 µM -1.46149288003802 0.0912633562637051 no 3073 0.071940114040294 4488 3807862
SGTC_1009 4106-0057 9.87 µM -1.46169288776258 0.0912332173170281 no 3074 0.0719126935493613 4470 2928005
SGTC_1557 sumaresinolic acid 42.3 µM -1.46752007002582 0.0903583623015275 no 3075 0.071117316829712 4444 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_12 0849-0099 9.267 µM -1.46917548998932 0.0901109683564208 no 3076 0.0708925982174717 4417 6071388
SGTC_2074 5212007 75.395 µM -1.47200773574794 0.0896888714358058 no 3077 0.070509394311266 4393 758611
SGTC_2319 6033012 152.6 µM -1.47596546422674 0.0891015056304258 no 3078 0.0699765818501954 4439 847246
SGTC_1208 2323-2347 50.3 µM -1.47986885728963 0.0885250125658457 no 3079 0.0694541240990182 4490 5412760
SGTC_3339 9145883 14.936 µM -1.48149149067026 0.0882861847981329 no 3080 0.0692378253907792 4405 2030670
SGTC_955 1216-0110 33 µM -1.48229638613806 0.0881678943545357 no 3081 0.0691307247359027 4450 3619719
SGTC_3161 9100388 49.47 µM -1.48442442567534 0.0878557188766913 no 3082 0.0688481793837699 4557 25236368
SGTC_1628 st004252 77.7 µM -1.48545338701864 0.0877050700851235 no 3083 0.0687118812140841 4482 692968
SGTC_2747 doxorubicin 7.63 µM -1.48923739612514 0.0871527159903625 no 3084 0.0682124332733806 4539 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3341 9147222 25.867 µM -1.48990097080792 0.0870561218936388 no 3085 0.0681251381396609 4501 1939759
SGTC_1843 st055809 45.5 µM -1.48998832707973 0.0870434117246553 no 3086 0.0681136526005711 4520 16413835
SGTC_153 4077-0274 519.67 µM -1.49001160102238 0.0870400256447457 no 3087 0.0681105928117095 4502 3121976
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.49227850848139 0.0867106890351987 no 3088 0.0678130742038706 4531 1273210
SGTC_2837 9008476 45.46 µM -1.49378734058208 0.0864920024830209 no 3089 0.0676156056967882 4451 2992805
SGTC_122 0236-0016 402.397 µM -1.49818069685546 0.0858575882810742 no 3090 0.067043154714555 4493 6808838
SGTC_710 3448-4187 58 µM -1.50811416862139 0.0844360138418532 no 3091 0.0657626547697923 4466 3946412
SGTC_2702 st077768 96.8 µM -1.50954805448912 0.0842322782388688 no 3092 0.0655793923080696 4466 6484119
SGTC_173 1273-0061 2.693 µM -1.51194560189603 0.0838924440754321 no 3093 0.0652738508837653 4454 2847414 YPL266W DIM1
SGTC_2596 sinensetin 100 µM -1.51694857422645 0.0831866283311284 no 3094 0.0646398341770034 4511 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_281 1672-3440 14.9 µM -1.52049355221895 0.082689214680658 no 3095 0.0641934890197603 4545 6833000
SGTC_1153 4055-0057 267 µM -1.52314267278299 0.0823189670553482 no 3096 0.0638615073787943 4541 882706
SGTC_101 0490-5701 117.494 µM -1.52824572482131 0.0816092727283829 no 3097 0.0632257699743834 4380 4661669
SGTC_1301 naphtanilide LB 4.81 µM -1.52856246920715 0.0815653748187675 no 3098 0.063186473019764 4555 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_775 4577-0580 57.3 µM -1.53027786079766 0.0813279463186566 no 3099 0.0629739829457778 4533 2006902
SGTC_1490 4089-0339 670 nM -1.53043304351111 0.0813064931175351 no 3100 0.0629547875435644 4490 742542
SGTC_1272 0839-0021 27 µM -1.53249388086449 0.0810219977575555 no 3101 0.0627003032298774 4542 5027250
SGTC_2471 5466956 24.79 µM -1.5338244543359 0.0808387137293785 no 3102 0.0625364225896066 4513 724419
SGTC_2262 9014885 67.46 µM -1.53570291478914 0.0805804924347546 no 3103 0.0623056299381129 4550 6457424
SGTC_1204 4049-0315 18.3 µM -1.53609524925506 0.0805266391798884 no 3104 0.0622575106457254 4526 588402
SGTC_964 1287-0107 19.4 µM -1.53710244435935 0.0803885124104741 no 3105 0.0621341122466009 4501 51516812 YPR165W RHO1
SGTC_694 1315-0438 43.2 µM -1.53974814916931 0.080026533177401 no 3106 0.061810877623725 4544 6793154
SGTC_305 1682-2595 20.8 µM -1.54073341622249 0.0798920465831358 no 3107 0.0616908402175453 4523 226033
SGTC_2014 4013930 200 µM -1.54091883737902 0.079866756159484 no 3108 0.0616682702838809 4500 64556
SGTC_3269 9137823 49.47 µM -1.54922892303267 0.0787395122852439 no 3109 0.0606633494894258 4461 17682936
SGTC_2159 5658611 73.75 µM -1.55148724705067 0.0784352690608269 no 3110 0.060392480599896 4506 793844
SGTC_2080 5212524 12.4 µM -1.55281773481893 0.0782564423762047 no 3111 0.0602333422752717 4472 260183
SGTC_704 1310-0270 142 µM -1.55339370388546 0.0781791241509775 no 3112 0.0601645530754087 4509 5718033
SGTC_3150 9097574 49.47 µM -1.56349326984905 0.0768327544761035 no 3113 0.0589683087296527 4557 17217476
SGTC_1221 2958-7315 257 µM -1.56449543312633 0.0767001237702151 no 3114 0.0588506323182467 4549 4562705
SGTC_1302 1159-0335 255 µM -1.5663046512212 0.0764611248496338 no 3115 0.0586386563188782 4551 649284
SGTC_1059 3448-6867 171 µM -1.5694735866101 0.0760438722298251 no 3116 0.0582688146828187 4492 3934407
SGTC_459 nigericin 15.3 µM -1.57435342154362 0.0754047391908135 no 3117 0.0577028828879032 4547 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2271 7849410 118.62 µM -1.57450786278028 0.0753845784000251 no 3118 0.0576850426007417 4475 972430
SGTC_2905 7799065 20.05 µM -1.57559848729457 0.0752423249821338 no 3119 0.0575591824912405 4422 1296806
SGTC_1713 st033146 12.748 µM -1.57634772816075 0.0751447179055357 no 3120 0.0574728439237182 4502 674619
SGTC_1143 3454-2408 5.08 µM -1.57980384164512 0.0746957234832879 no 3121 0.0570758977918972 4542 X1143
SGTC_336 4111-0029 111 µM -1.58186554082686 0.074428858333593 no 3122 0.0568401344910824 4555 3131175
SGTC_2277 7947813 106.88 µM -1.58209422832321 0.0743993020616034 no 3123 0.05681403051301 4548 1246798
SGTC_1854 st056233 32.9 µM -1.58538920379375 0.0739744434571117 no 3124 0.0564389663022742 4474 5393174
SGTC_2005 4024620 188 µM -1.58596660237917 0.0739001841633531 no 3125 0.0563734429174599 4492 236743
SGTC_1917 st066507 28.5 µM -1.59061379654687 0.0733045808544966 no 3126 0.0558482588164187 4488 3156428
SGTC_1590 st077108 57.8 µM -1.59145903184687 0.073196647836006 no 3127 0.0557531541414427 4554 5489485
SGTC_640 3381-0960 37.1 µM -1.59458696664555 0.0727982809947429 no 3128 0.0554023145155927 4587 1745025
SGTC_1147 3809-1045 12.3 µM -1.60431131815194 0.0715704083692338 no 3129 0.0543227237690061 4563 325925
SGTC_2099 5377090 177.372 µM -1.60809537112245 0.0710969222415322 no 3130 0.0539071464241436 4535 2243829
SGTC_857 0438-0306 1.35 µM -1.60822410195608 0.071080856985147 no 3131 0.0538930531698745 4594 4686136
SGTC_2278 7948257 134.34 µM -1.60959315651226 0.0709101751497502 no 3132 0.0537433516000475 4554 1247028
SGTC_2184 6075246 200 µM -1.61187135486565 0.0706268472514297 no 3133 0.0534949683725695 4534 2267320
SGTC_2270 7924575 90.91 µM -1.6126450938203 0.070530819468443 no 3134 0.0534108177966549 4518 1262135
SGTC_1451 4152-0210 104 µM -1.61458681886563 0.0702902763533446 no 3135 0.0532001008923118 4581 659563
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.61870972087733 0.0697816189708162 no 3136 0.0527548671706365 4490 4000243
SGTC_3141 9094609 49.47 µM -1.61997031934959 0.0696266612640694 no 3137 0.0526193264130609 4508 25236309 YDL196W YDL196W
SGTC_3181 9108277 49.47 µM -1.62075167309221 0.0695307472755162 no 3138 0.0525354533407714 4541 17097298
SGTC_1025 k007-0731 70 µM -1.62247234137952 0.0693198877941995 no 3139 0.052351125309258 4540 6256118
SGTC_3016 9080866 49.47 µM -1.62493296226085 0.0690192070538488 no 3140 0.0520884218888735 4539 17066299
SGTC_3032 9089427 49.47 µM -1.62891377015063 0.0685348937391423 no 3141 0.0516656373015481 4528 17173707
SGTC_3315 9136395 68.55 µM -1.63000938634718 0.068402059917392 no 3142 0.0515497565970264 4545 16876844
SGTC_1085 doxorubicin 7.67 µM -1.63508632198101 0.0677891176624865 no 3143 0.0510154765447332 4571 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1305 1181-0477 144 µM -1.63637927698598 0.0676336980450386 no 3144 0.0508801167652032 4596 6252086
SGTC_711 k292-0785 179 µM -1.63769735658408 0.0674755418489433 no 3145 0.0507424211627635 4502 4146315
SGTC_130 0136-0219 337.655 µM -1.63984398172129 0.0672185805580685 no 3146 0.0505188053804453 4477 234244
SGTC_2746 daunorubicin 9.88 µM -1.64799040592494 0.0662502938970696 no 3147 0.0496773199781408 4593 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3149 9097855 49.47 µM -1.65133986142035 0.0658553245047509 no 3148 0.0493345985968046 4550 25236625 YMR079W SEC14
SGTC_455 paf C-16 10 µM -1.65140552471737 0.0658475997364924 no 3149 0.0493278987430013 4542 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1387 3342-1166 1.8 µM -1.65570895794844 0.065342864367047 no 3150 0.0488903861721407 4562 3418228
SGTC_3100 9120536 49.47 µM -1.65710211790458 0.0651801099239122 no 3151 0.0487494155168115 4481 16421196
SGTC_3143 9086658 49.47 µM -1.66006179105033 0.0648353933422498 no 3152 0.0484510112481256 4534 25236626
SGTC_1332 1480-0653 17.5 µM -1.66371102688479 0.0644123131297688 no 3153 0.0480850958000653 4578 5749438
SGTC_1453 4237-0541 195 µM -1.66557124100322 0.0641974731625396 no 3154 0.0478994215959223 4580 739892
SGTC_3079 9117512 49.47 µM -1.66674111089217 0.0640626480267729 no 3155 0.0477829472336641 4645 7185044
SGTC_2913 7966556 36.57 µM -1.67206300469289 0.0634520874514128 no 3156 0.047255949389999 4486 2976516
SGTC_1112 tnp00069 1.16933 µM -1.67556911096134 0.0630523264751453 no 3157 0.0469113117082501 4550 145826
SGTC_2804 7954240 19.48 µM -1.6764871163861 0.0629479816013919 no 3158 0.0468214088520941 4582 828705
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.67803984616932 0.0627717971788268 no 3159 0.0466696602728371 4581 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_222 nsc-310342 10.666 µM -1.67819321664023 0.0627544154827164 no 3160 0.0466546927861387 4602 432556
SGTC_2487 5918373 44.05 µM -1.68299057031843 0.0622126157632698 no 3161 0.0461884584439834 4622 2876279
SGTC_1003 4049-0218 100 µM -1.68668998173764 0.061797311779965 no 3162 0.0458314897280496 4581 295161
SGTC_1032 k061-1018 98.7 µM -1.68746318036263 0.0617107848664191 no 3163 0.0457571620212516 4612 4005393
SGTC_1437 4092-1038 11.6 µM -1.69179922138711 0.0612272996799778 no 3164 0.0453421310583647 4639 3977136
SGTC_621 3584-0052 32.1 µM -1.69200342100601 0.061204603826999 no 3165 0.0453226606757805 4611 2273927
SGTC_49 0717-0965 32.132 µM -1.70351351101563 0.0599359068146534 no 3166 0.0442360058653699 4633 5889349 YGL099W LSG1
SGTC_2165 5727197 32.143 µM -1.71325827474874 0.058877974059778 no 3167 0.043332517488692 4613 1361712
SGTC_415 dibenzyl ketone 100 µM -1.71758593238625 0.0584128690810724 no 3168 0.0429360840323389 4573 7593
SGTC_664 1222-0054 14.9 µM -1.71878566580411 0.0582844426626432 no 3169 0.0428267032704872 4578 6813991
SGTC_2941 9056145 11.23 µM -1.71949039763689 0.0582091075539306 no 3170 0.0427625573129926 4550 2119517
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.7219380810908 0.0579480468374992 no 3171 0.042540367831795 4565 6708630 An antioxidant.
SGTC_1102 cgs 12066b 26.1 µM -1.7220214805361 0.057939168004808 no 3172 0.0425328136903938 4611 6438352 A 5-HT1B full agonist.
SGTC_2420 aureobasidin a 50 nM -1.7337062603398 0.0567057234839489 no 3173 0.0414851075898293 4636 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_3323 9138564 53.9225 µM -1.7345947498082 0.0566127873417489 no 3174 0.0414063050411506 4626 43912313 YNL103W MET4
SGTC_726 3448-4391 34.2 µM -1.73924975045747 0.0561278334654843 no 3175 0.040995420946946 4662 1356692
SGTC_3156 9099931 49.47 µM -1.73975097144132 0.0560758126487544 no 3176 0.0409513774450706 4640 18111053
SGTC_2100 5377183 190 µM -1.74109334733832 0.0559366771667756 no 3177 0.0408336086482925 4623 2844202
SGTC_2967 9089538 49.85 µM -1.75610624158287 0.0543990993373471 no 3178 0.0395351347932326 4590 728216
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.75620552856664 0.0543890430775806 no 3179 0.0395266605258592 4584 1241132 A phosphatase inhibitor.
SGTC_3326 9140064 16.379 µM -1.75655415324001 0.0543537443529222 no 3180 0.0394969166780693 4570 1868434
SGTC_1494 4358-1428 177 µM -1.76340755891376 0.0536635010223011 no 3181 0.0389158879211247 4638 1564571
SGTC_2572 astragaloside iv 100 µM -1.76869941534339 0.0531352948860422 no 3182 0.0384720249573302 4576 45006101 An anti-inflammatory agent.
SGTC_1845 st056753 3.01 µM -1.77372184111796 0.0526378027189082 no 3183 0.038054585932105 4587 5375839
SGTC_568 1193-0097 7.48 µM -1.7750647478196 0.0525054104530225 no 3184 0.0379435984334199 4421 3646150
SGTC_2133 5320837 200 µM -1.77711572826005 0.0523037220402904 no 3185 0.0377746004471959 4622 2841355
SGTC_2143 5623677 140.463 µM -1.77897706358538 0.0521212158141653 no 3186 0.0376217611977629 4601 5375313
SGTC_2251 lansoprazole 556 µM -1.78804150330916 0.0512396553277637 no 3187 0.036884656039842 4607 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1033 k072-0102 21.3 µM -1.78915792710899 0.0511319031459167 no 3188 0.0367946926390119 4569 5965931
SGTC_24 0417-1663 219 µM -1.79294412160742 0.0507678188935871 no 3189 0.0364909296964071 4649 4329390
SGTC_2682 pyrogallin 40.03 µM -1.79346688075854 0.0507177124428924 no 3190 0.0364491508831493 4641 822798 An ATP competetive kinase inhibitor.
SGTC_2894 9048625 32.47 µM -1.79461895113855 0.050607425564964 no 3191 0.0363572158165054 4632 4092861
SGTC_1432 4049-0298 68.4 µM -1.79941098736435 0.0501507356922603 no 3192 0.0359768464113533 4652 741646
SGTC_3009 9080819 71.4286 µM -1.80034374032355 0.0500622257776572 no 3193 0.0359031891544614 4626 17027216
SGTC_2563 tomatine 8.54 µM -1.80212763333617 0.0498932971974505 no 3194 0.0357626634944714 4550 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2102 5377816 72.7585 µM -1.80319912123258 0.0497920497008884 no 3195 0.0356784742253994 4652 1379702
SGTC_761 k216-0224 480 µM -1.80516260639969 0.0496069406299022 no 3196 0.0355246202633614 4630 1340404
SGTC_280 3448-3607 3.04 µM -1.81194323192133 0.0489719114166354 no 3197 0.0349974842406304 4598 626179
SGTC_1413 3910-0535 34.4 µM -1.8208602302982 0.0481467086389623 no 3198 0.0343140529507874 4653 2876951
SGTC_1632 st005650 90 µM -1.82249001866196 0.0479970932538849 no 3199 0.0341903334341371 4640 2759605
SGTC_737 1950-0117 57.9 µM -1.82512953488655 0.0477555739349199 no 3200 0.0339907420849373 4624 5393513
SGTC_1951 sophoraflavanone G 9.2 µM -1.82604692102324 0.0476718601062841 no 3201 0.0339215972176131 4584 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2536 dehydroabietamide 32.04 µM -1.83025053844204 0.047289771244328 no 3202 0.0336062418904026 4645 3983547
SGTC_2371 9071574 200 µM -1.83204617650345 0.0471273061881647 no 3203 0.0334722706258772 4645 45596039
SGTC_2 0422-0095 29 µM -1.83708180757282 0.0466740803053258 no 3204 0.0330989097007038 4579 6790840
SGTC_1341 1486-1360 280 µM -1.84172193655929 0.0462595534416225 no 3205 0.032757916879409 4644 3976547
SGTC_104 0074-0074 590.992 µM -1.84780883801488 0.0457202670909293 no 3206 0.0323150009622967 4553 3943124
SGTC_894 0960-0238 55.9 µM -1.85209428240632 0.045343626088469 no 3207 0.0320061427020095 4636 6741907 YDL195W SEC31
SGTC_2163 5671233 125 µM -1.85314208095666 0.0452519174488618 no 3208 0.0319309983364134 4591 701023
SGTC_321 4534-3890 65.3 µM -1.85921455135279 0.0447233586383437 no 3209 0.0314983665280614 4640 699746
SGTC_157 1348-1695 65.819 µM -1.86029432838408 0.0446298955941481 no 3210 0.0314219477735286 4560 5380510
SGTC_228 caffeine 993.056 µM -1.86428664828506 0.0442856948198778 no 3211 0.031140730399267 4641 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_3104 9120930 49.47 µM -1.8687419050767 0.0439041110586605 no 3212 0.030829365439564 4658 17014836
SGTC_2765 myclobutanil 7.74 µM -1.87157574516039 0.0436627812784379 no 3213 0.0306326608067548 4644 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1119 parthenolide 318.541 nM -1.87417913545919 0.0434420210615106 no 3214 0.0304528694485647 4663 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2584 androsterone 48.74 µM -1.8771146256339 0.0431941814280018 no 3215 0.0302511926338331 4542 2754130 A steroid.
SGTC_2739 tacrine 100.86 µM -1.88469437882259 0.0425595112468643 no 3216 0.0297355558625895 4688 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_182 3448-4371 550.524 µM -1.88529120774257 0.0425098593350245 no 3217 0.0296952662736961 4588 3491403
SGTC_1207 2099-0101 141 µM -1.88974528017492 0.042140789915489 no 3218 0.029396017533506 4659 5837381
SGTC_2388 9080168 200 µM -1.89524828777578 0.0416883902424598 no 3219 0.0290297577971919 4671 15943073
SGTC_660 4031-1742 102 µM -1.90183507566468 0.0411520743515028 no 3220 0.0285963595681038 4548 6738706
SGTC_1710 st031758 61.5 µM -1.90340474611939 0.0410250960356724 no 3221 0.0284938761052085 4684 5394341
SGTC_1435 4092-0789 56.7 µM -1.90538439685916 0.0408654056991136 no 3222 0.0283650609762241 4679 2248285
SGTC_1587 estradiol valerate 56.1 µM -1.92712663562267 0.0391445214722553 no 3223 0.0269819250255506 4698 13791 A steroid.
SGTC_2705 st078069 42.8 µM -1.92785433012396 0.0390879610794645 no 3224 0.0269366238462643 4661 1530061
SGTC_1367 1812-0510 76.9 µM -1.92880394485996 0.0390142519102518 no 3225 0.0268776029651212 4683 1142582 YDR527W RBA50
SGTC_3333 9141820 12.094 µM -1.92905252786095 0.0389949755795916 no 3226 0.0268621707656545 4640 1939433
SGTC_604 1000-0114 314 µM -1.93477878408516 0.0385530766274924 no 3227 0.0265087238235365 4678 1572745
SGTC_3289 9119912 71.43 µM -1.93728545592473 0.0383609235602012 no 3228 0.0263552295602824 4647 17014829
SGTC_384 k007-0144 5.16 µM -1.94306047821559 0.0379212002995861 no 3229 0.0260044257464449 4647 6824886
SGTC_1997 st073024 93.8 µM -1.95169795944915 0.0372712067588353 no 3230 0.0254870375112181 4709 686268
SGTC_1030 k029-0042 36.7 µM -1.96457363224568 0.036319201978447 no 3231 0.0247318031392742 4662 6080581
SGTC_1814 st052110 31.539 µM -1.96481950595104 0.0363012180166948 no 3232 0.0247175658691771 4619 674163
SGTC_2225 6654152 15.4 µM -1.96590334744051 0.036222029373463 no 3233 0.0246548881654462 4647 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2981 9013952 38.96 µM -1.96986479453809 0.0359337966953825 no 3234 0.0244269340973703 4606 2996344
SGTC_646 4092-0839 27.3 µM -1.97051206911037 0.035886880418129 no 3235 0.0243898565768275 4688 877796
SGTC_2541 muurolladie-3-one 83.07 µM -1.98156114511527 0.0350937233626041 no 3236 0.0237641897587592 4619 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1118 chelidonine 707.474 nM -1.99267414339144 0.0343105447324698 no 3237 0.0231485702502544 4668 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2752 diclazuril 33.15 µM -2.00285454994617 0.033605751645989 no 3238 0.0225964513529874 4605 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_478 N-arachidonylglycine 10 µM -2.00591156541515 0.033396454715403 no 3239 0.022432842047362 4728 5283389
SGTC_650 1328-0195 38 µM -2.00722726935046 0.0333067067144676 no 3240 0.0223627346450382 4684 2780821
SGTC_1880 MG-132 525 µM -2.01951582399134 0.0324780227198381 no 3241 0.0217168171499964 4659 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2836 9010338 19.48 µM -2.02396114890027 0.0321824711974826 no 3242 0.021487074677743 4633 2994051
SGTC_1686 st019653 115.5 µM -2.02749746480993 0.0319489446308337 no 3243 0.0213057817275287 4699 97252
SGTC_3245 9134821 49.47 µM -2.02975940372622 0.0318003088470124 no 3244 0.0211905006705102 4711 17014901
SGTC_1120 ficusin 1.78878 µM -2.03021144183043 0.031770673262882 no 3245 0.0211675256499615 4664 6199 A DNA cross-linker.
SGTC_1282 0886-0010 32.4 µM -2.03205738021695 0.0316498904221961 no 3246 0.0210739236780691 4697 2836211 YNL267W PIK1
SGTC_3185 9108267 49.47 µM -2.03378774297361 0.0315370146958525 no 3247 0.020986500439193 4679 4910486
SGTC_1560 lithocholic acid 53.1 µM -2.03610004638333 0.0313866971988725 no 3248 0.020870155046176 4652 9903 A bile acid which acts as a detergent.
SGTC_2132 5317594 122.667 µM -2.03634025010289 0.0313711161330564 no 3249 0.0208581003703132 4638 794577
SGTC_103 0844-0104 51.839 µM -2.03804788707822 0.0312605327270295 no 3250 0.0207725720270608 4517 5375804
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -2.04090195819045 0.0310764281771955 no 3251 0.0206302865738711 4692 6710655
SGTC_1600 coumarin 106 71.1 µM -2.04417841422613 0.0308661842747948 no 3252 0.0204679624144857 4708 100336 A hepatotoxic, DNA x-linker.
SGTC_1663 st014140 55.4 µM -2.04555471172049 0.0307782217338772 no 3253 0.020400100546561 4731 4207120
SGTC_1642 st009582 77.7 µM -2.04664274741073 0.030708829682816 no 3254 0.0203465872129719 4694 6739311
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -2.04710801442742 0.0306791957446262 no 3255 0.0203237401276249 4710 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_757 1066-0008 322 µM -2.06130596102297 0.0297862201806712 no 3256 0.0196369299396486 4702 6842497
SGTC_1578 josamycin 24.2 µM -2.06197615519321 0.0297446071454879 no 3257 0.0196050030982834 4698 5282165 A P450 substrate.
SGTC_2684 capsaicin 100 µM -2.06651816481649 0.02946385859593 no 3258 0.0193897895156604 4725 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_944 3370-0224 231 µM -2.06700888433044 0.0294336585872091 no 3259 0.0193666584053935 4674 4580514
SGTC_588 3970-1144 52.9 µM -2.06903075747322 0.0293094988230374 no 3260 0.0192716002663612 4636 1888707
SGTC_112 phenothiazine 287.218 µM -2.07060609897828 0.029213061544294 no 3261 0.019197810873003 4685 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1733 st037357 54.9 µM -2.07373792970608 0.0290221238328779 no 3262 0.0190518282792036 4642 1272339 YGL099W LSG1
SGTC_260 nsc-65238 3.989 µM -2.08307954188793 0.0284587463764523 no 3263 0.0186219869116491 4711 3246252
SGTC_570 0987-0065 62.6 µM -2.09562149352103 0.0277166978235512 no 3264 0.0180578905078241 4635 3104428
SGTC_3175 9106517 49.47 µM -2.09708026512681 0.0276314454437148 no 3265 0.0179932353257507 4709 41468073
SGTC_2229 7354935 190 µM -2.09949717616598 0.0274906793179591 no 3266 0.0178865482428344 4706 318112
SGTC_1012 4112-3522 18 µM -2.11716334010083 0.0264798178826918 no 3267 0.0171229937664398 4701 3112398
SGTC_3232 9132874 49.47 µM -2.12092889340818 0.0262684168307748 no 3268 0.0169638933748413 4689 3784940
SGTC_693 4161-2696 114 µM -2.13095015386062 0.025712679744497 no 3269 0.0165466244467269 4730 805759
SGTC_1405 3909-7894 12 µM -2.13842427664724 0.0253046326589586 no 3270 0.0162411619439077 4714 7104060
SGTC_2220 6782180 200 µM -2.14248279263233 0.0250853415213417 no 3271 0.0160773259446856 4713 833803
SGTC_1419 3993-2473 62.6 µM -2.14783871708645 0.0247983885477105 no 3272 0.0158632850611285 4756 704026
SGTC_215 1287-0124 461.5 µM -2.16548420116892 0.0238724078813633 no 3273 0.0151753120014665 4747 5560863
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -2.17532041428756 0.0233689699900366 no 3274 0.0148030568884187 4725 16623 A steroid.
SGTC_117 lucigenin 22.078 µM -2.20074695468989 0.0221088301742347 no 3275 0.0138769713625548 4681 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2816 7982706 58.44 µM -2.20682443747399 0.0218162716740272 no 3276 0.0136631635416292 4690 2981853
SGTC_525 k781-2675 26.7 µM -2.21197344319044 0.0215709732877828 no 3277 0.0134842499741446 4687 3651118 YDL195W SEC31
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -2.22330162859739 0.0210394947880792 no 3278 0.0130977338914573 4680 6708739 YPR165W RHO1
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -2.2277883372233 0.0208320792846221 no 3279 0.0129473164738309 4689 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2766 oltipraz 83.91 µM -2.24312701487305 0.0201360175406681 no 3280 0.0124443125306111 4718 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_923 1900-2434 73.3 µM -2.24628595510755 0.0199951425237204 no 3281 0.0123428487974715 4696 5910570
SGTC_1364 1653-0028 37.6 µM -2.25669152824898 0.0195369981410847 no 3282 0.0120136782925893 4749 5718652
SGTC_3072 9116419 49.47 µM -2.26013849508832 0.0193872118204364 no 3283 0.0119063283208963 4717 17170162
SGTC_53 0973-0023 39.979 µM -2.2796430409791 0.0185579101921064 no 3284 0.0113144340186498 4681 674768
SGTC_480 am 92016 50 µM -2.28379119805175 0.0183854866624441 no 3285 0.0111919026078891 4745 2129 K+ channel blocker.
SGTC_1565 sinapyl alcohol 95.1 µM -2.2975925600356 0.0178216047771933 no 3286 0.0107924947506707 4724 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1429 4049-0205 9.46 µM -2.3049100889376 0.0175286637396581 no 3287 0.0105858047292162 4770 22774478
SGTC_3101 9120531 49.47 µM -2.30581972988467 0.0174925371565239 no 3288 0.0105603536565327 4711 24824904
SGTC_365 0121-0052 13.6 µM -2.30947859469929 0.017347865962251 no 3289 0.010458519072707 4704 3101739
SGTC_2722 naftopidil 47.16 µM -2.31437120929129 0.0171560102388878 no 3290 0.0103236843779001 4705 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_138 0850-0259 40.9225 µM -2.3290343231846 0.016591844482484 no 3291 0.00992862373081231 4683 6813004
SGTC_1791 st048313 56.1 µM -2.33219573929216 0.016472311229029 no 3292 0.0098451981120215 4755 1204976
SGTC_2069 5228469 200 µM -2.34226939462442 0.0160963309668371 no 3293 0.00958343728521715 4729 2835210
SGTC_360 0957-0399 1.01 µM -2.34300009554951 0.0160693473066815 no 3294 0.00956468909854313 4743 6752301 YPR165W RHO1
SGTC_1618 st003135 44.5 µM -2.3459691629013 0.0159601026508636 no 3295 0.00948883875844529 4738 1270615
SGTC_382 3229-0966 23.2 µM -2.34931263559418 0.0158378447858448 no 3296 0.00940405364770724 4762 5722370
SGTC_2297 7971671 152.32 µM -2.35880345016983 0.0154951688504273 no 3297 0.00916698171695754 4714 909016
SGTC_1509 1326-1131 80 µM -2.36204543105565 0.0153795811891087 no 3298 0.00908720740834418 4736 768313
SGTC_226 1,3-diallylurea 8.28947 mM -2.36615116887311 0.015234260795776 no 3299 0.00898705180139552 4745 74537 YKL182W FAS1
SGTC_1989 st071868 50.2 µM -2.37328889879255 0.0149844316173751 no 3300 0.00881523396727136 4750 16414057
SGTC_1555 citronellol 128 µM -2.40556913592588 0.0138980879109067 no 3301 0.00807364816560246 4755 8842 A terpine precursor.
SGTC_3266 9136860 49.47 µM -2.40793143346819 0.0138213250728575 no 3302 0.00802159690186819 4555 4871271 YPR165W RHO1
SGTC_3131 9127911 49.47 µM -2.41295340521912 0.0136593502975352 no 3303 0.00791192117135595 4724 45595681
SGTC_3219 9131112 49.47 µM -2.41970061199964 0.0134443114379681 no 3304 0.00776664501950903 4637 17612988 YMR079W SEC14
SGTC_1652 st011932 78 µM -2.42246997148539 0.0133568994385722 no 3305 0.00770769986863684 4738 1551076
SGTC_2117 5521686 200 µM -2.42629353570978 0.0132370194518589 no 3306 0.00762696348662695 4757 803312
SGTC_1161 k007-0610 110 µM -2.42969090811532 0.0131312828614106 no 3307 0.00755585204150257 4706 5843850
SGTC_2709 st078560 56 µM -2.43030604235161 0.0131122162556556 no 3308 0.00754303909937684 4744 17250903
SGTC_3271 9137798 49.47 µM -2.44004551760245 0.0128135063016467 no 3309 0.00734270570871506 4758 6498326
SGTC_893 0958-0369 48.9 µM -2.45042200170368 0.0125017535650554 no 3310 0.0071344436642901 4628 6819948
SGTC_990 3985-0011 41.3 µM -2.45115464254278 0.0124799923399223 no 3311 0.0071199380542625 4747 5399565 YGL099W LSG1
SGTC_1939 st074455 53.6 µM -2.47399933934273 0.0118177101879959 no 3312 0.00668049719348755 4710 1644229
SGTC_586 0957-0265 8.15 µM -2.48084223385913 0.0116253611270771 no 3313 0.00655361859529076 4714 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1570 verbenone 133 µM -2.5047703356186 0.0109739714328035 no 3314 0.00612654638248498 4756 29025 A natural terpanoid with antifungal properties.
SGTC_2756 carbadox 75.1 µM -2.51754903047885 0.010639285803085 no 3315 0.00590872602175871 4695 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3098 9119039 49.47 µM -2.52661355894089 0.0104073002647176 no 3316 0.00575840744366144 4759 17161528
SGTC_888 0916-0002 6.97 µM -2.53698290600762 0.0101473389262169 no 3317 0.00559062068244839 4762 2802138 YIL048W NEO1
SGTC_2301 7769476 200 µM -2.54017207092116 0.0100685334960042 no 3318 0.00553989713139951 4758 977820
SGTC_2795 7780010 54.55 µM -2.54370532190843 0.00998184968245341 no 3319 0.00548417865385979 4737 953673
SGTC_2282 7944268 200 µM -2.59068685079842 0.00888966465481375 no 3320 0.00478923036760426 4752 2970414
SGTC_2528 xanthyletin 44.79 µM -2.60002719606742 0.00868546362953824 no 3321 0.00466081863343161 4762 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2949 9072542 2.23 µM -2.60039047996425 0.00867760521151676 no 3322 0.00465588683797689 4733 16457352
SGTC_1247 0448-0043 5.84 µM -2.61595894773393 0.00834664077472522 no 3323 0.00444886273050585 4742 3089013 YGL099W LSG1
SGTC_1036 k216-0215 33.5 µM -2.64042019018287 0.00784900076886918 no 3324 0.00414016464350539 4746 622330
SGTC_3 0833-0587 95.581 µM -2.64259535526237 0.00780603938523934 no 3325 0.00411366474699295 4694 5382644
SGTC_2421 5690543 90.72 µM -2.66510374217004 0.00737348423818448 no 3326 0.00384822879412192 4728 3397993
SGTC_1211 1056-0033 32.3 µM -2.68247543753932 0.00705422939877136 no 3327 0.00365397590621996 4782 6741922
SGTC_1658 st012944 20 µM -2.7249277176394 0.00632484115635724 no 3328 0.00321577828616452 4682 24207260
SGTC_135 0933-0004 26.348 µM -2.74389865428916 0.00602106527590377 no 3329 0.0030357139353459 4740 21230617 YGL099W LSG1
SGTC_2686 alizarin 95.37 µM -2.74789119504856 0.00595880631204999 no 3330 0.00299899548250623 4767 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_933 2914-0560 114 µM -2.81216524678663 0.00503217800442154 no 3331 0.00246046076673549 4775 463887
SGTC_2583 asiatic acid 100 µM -2.83595297156452 0.00472322855966553 no 3332 0.00228445866256595 4758 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1524 corynanthine 62.1 µM -2.83739142173419 0.0047051006563342 no 3333 0.00227419069565345 4792 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_940 3232-1287 54.8 µM -2.84301039778066 0.00463488144651054 no 3334 0.00223448062249024 4773 1585493 YIL048W NEO1
SGTC_2924 9010168 62.78 µM -2.88961849862385 0.0040875495736851 no 3335 0.00192854802397181 4768 2993929
SGTC_1649 st011737 51.3 µM -2.89899727662311 0.00398467424069062 no 3336 0.00187179072945646 4783 1761035
SGTC_266 formosanin C 406 nM -2.90317949039769 0.0039395519310567 no 3337 0.00184697429871476 4730 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2166 5933061 31.504 µM -2.9170456021578 0.00379320527519285 no 3338 0.0017668205280768 4750 2877375
SGTC_2279 7948423 32.93 µM -2.95617965928665 0.00340610310667151 no 3339 0.00155737799841015 4770 1247112
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -3.04344540594457 0.00266780192528314 no 3340 0.00116942937367245 4783 364106
SGTC_2275 7947463 200 µM -3.05062812646644 0.00261400123223314 no 3341 0.0011418161095615 4789 1225414
SGTC_2544 sphondin 68.51 µM -3.19385376610404 0.00172675919748878 no 3342 0.000701936056210106 4779 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_513 4245-1575 41.7 µM -3.26196016914237 0.00140981166827496 no 3343 0.000553223444741821 4731 719745
SGTC_2565 isoliquiritigenin 100 µM -3.2824303428033 0.0013255069150995 no 3344 0.00051458204604094 4768 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_491 tetrandrine 80.3 µM -3.28667113332498 0.0013086284192816 no 3345 0.000506895765430565 4800 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_255 tunicamycin 200.472 nM -3.34219091611018 0.00110506110319989 no 3346 0.000415599344202721 4781 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2582 agaric acid 100 µM -3.46731243292428 0.000748243071446774 yes 3347 0.000262845240005686 4660 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1322 1348-1070 12 µM -3.5398179817497 0.000593552294095864 yes 3348 0.000200201542533903 4796 6758089
SGTC_2953 9074162 66.49 µM -3.54646536762302 0.000580961224483351 yes 3349 0.000195218028705501 4796 16451992
SGTC_2436 5633522 8.09 µM -3.56684516780702 0.000543881182112846 yes 3350 0.000180652404916248 4799 5724242
SGTC_1522 st012842 45.6 µM -3.72164666650749 0.000326042673006286 yes 3351 9.89639249179163e-05 4773 3491067 YOR116C RPO31
SGTC_1404 3909-7820 48.3 µM -3.72403059512105 0.000323435453325486 yes 3352 9.8033574657744e-05 4807 23741373
SGTC_1855 st056195 39.6 µM -3.92011247516996 0.000164540522408008 yes 3353 4.42538257722152e-05 4800 4028379
SGTC_2424 5537928 59.2 µM -3.96421665644684 0.000140741198747253 yes 3354 3.68186760517658e-05 4806 5382802
SGTC_3075 9116269 49.47 µM -4.76687566924167 6.24040854405616e-06 yes 3355 9.35523449704277e-07 4809 17015205 YNL244C SUI1
SGTC_453 enantio-paf c16 10 µM -7.90383493213578 2.0789822469549e-13 yes 3356 1.35225560765192e-15 4780 13871343 A lipid and platelet activating factor