SGTCid condition conc unit GPI15|YNL038W.score GPI15|YNL038W.strain.pval GPI15|YNL038W.strain.significant GPI15|YNL038W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1908 st060353 56.5 µM 4.6029083982578 4.00694552216136e-07 yes 1 2.08315752254356e-06 7 4227716
SGTC_3157 9099274 49.47 µM 4.43900907630324 9.71574054344393e-07 yes 2 4.51870029150304e-06 4 17217662
SGTC_3224 9130643 49.47 µM 4.04781591680253 7.1339081604467e-06 yes 3 2.58488895614428e-05 7 17644395
SGTC_1562 morin hydrate 59.1 µM 4.04118320673826 7.36842808341929e-06 yes 4 2.65910944254871e-05 7 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2620 irigenin 100 µM 4.03822023624522 7.47555221199494e-06 yes 5 2.69291380450999e-05 13 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_431 k089-0097 107 µM 4.01775811734848 8.25691776266683e-06 yes 6 2.93772307809722e-05 15 5499420
SGTC_2819 7996655 46.38 µM 3.86553650885974 1.70496359279028e-05 yes 7 5.54226328006154e-05 4 6456960
SGTC_2177 5811945 192 µM 3.78106913226624 2.52159862995391e-05 yes 8 7.8078149798041e-05 4 5343475
SGTC_953 1188-0045 9.7 µM 3.66318879081509 4.29719106271874e-05 yes 9 0.00012454740383046 9 6144426
SGTC_3214 9129694 49.47 µM 3.65275245317915 4.50155164525881e-05 yes 10 0.000129722159453202 8 17158655
SGTC_747 3448-8087 38.7 µM 3.5301322533319 7.70123013436882e-05 yes 11 0.000207675993341865 11 5168703
SGTC_2877 9040724 71.43 µM 3.4996613037371 8.77814384505852e-05 yes 12 0.000232924828659006 4 6463895
SGTC_1558 st069300 45.6 µM 3.49732056745727 8.8664763879148e-05 yes 13 0.000234978369264094 4 24208000
SGTC_809 3998-0021 90 µM 3.47498163837192 9.75257573149043e-05 yes 14 0.000255444159756338 13 715485
SGTC_787 4152-0075 138 µM 3.47027199656954 9.94971627624798e-05 yes 15 0.000259965779656104 8 9566539
SGTC_2348 9022543 33.42 µM 3.34124194287246 0.00017054789063873 yes 16 0.000417022544545804 45 3162678 YDL140C RPO21
SGTC_3195 9113082 49.47 µM 3.24931646203011 0.000247620241547198 yes 17 0.000578413515346816 4 17018038
SGTC_69 0096-0274 206.684 µM 3.24571285042159 0.000251219472364902 yes 18 0.000585784731872353 49 6741392
SGTC_3190 9110366 49.47 µM 3.21290338835859 0.000286307084381839 yes 19 0.000657002408967213 8 17123768
SGTC_2981 9013952 38.96 µM 3.14406390271703 0.000375247405275905 yes 20 0.000833095252569308 19 2996344
SGTC_1829 berberine 14.4 µM 3.11276911977966 0.000423634509261133 yes 21 0.000926704740108945 22 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3177 9107506 49.47 µM 3.0637430278826 0.000511194152809903 yes 22 0.00109293290706398 4 8897194
SGTC_833 3852-0053 558 µM 3.03707077444594 0.000565592665356528 yes 23 0.00119444679312871 15 3123681
SGTC_3204 9114183 49.47 µM 3.01040419949875 0.000625287091093205 yes 24 0.00130450118427612 17 17027248
SGTC_204 PMA1.184 62.41 µM 3.00103508037136 0.000647605502177523 yes 25 0.00134531782814704 17 2252213 YGL008C PMA1
SGTC_1645 Cervolide 78 µM 2.98310899141203 0.000692369644898306 yes 26 0.00142668182060511 11 23173 A fragrance.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 2.91810059348241 0.000879723979205451 yes 27 0.00176085359395908 15 16623 A steroid.
SGTC_657 3534-0529 86.7 µM 2.89749966215424 0.00094818918321605 yes 28 0.00188075071694143 12 1049549
SGTC_2402 5553605 200 µM 2.89144737932514 0.000969214166122882 yes 29 0.00191735901923373 21 6758546
SGTC_2769 toremifene 3.73 µM 2.87315521041591 0.00103538836802555 no 30 0.00203197202503356 21 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_356 1634-0012 32.5 µM 2.8724160928925 0.00103814735082497 no 31 0.00203673117879075 17 735457
SGTC_914 3820-6779 408 µM 2.86697752617813 0.00105865676116764 no 32 0.0020720621986523 11 2893481
SGTC_705 1124-0212 310 µM 2.86599669888612 0.00106239487504004 no 33 0.00207849290229825 23 9554485
SGTC_608 k048-0125 159 µM 2.84587202963122 0.00114181571703548 no 34 0.00221449949314652 17 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_585 0kpi-0023 191 µM 2.8404403930596 0.00116416435131404 no 35 0.00225256457272196 8 64601
SGTC_3235 9132602 49.47 µM 2.8190640605393 0.00125606300773514 no 36 0.00240819523933967 14 4912240
SGTC_589 1227-0070 34.1 µM 2.80749108677193 0.00130854061475453 no 37 0.00249645307764335 32 2841384
SGTC_1034 k072-0165 12.7 µM 2.78525832547117 0.0014150169009365 no 38 0.00267425468820606 18 5835461
SGTC_2831 7999036 19.48 µM 2.77651518224525 0.00145901375007009 no 39 0.00274725344311263 22 2988270
SGTC_3234 9132280 49.47 µM 2.77155109964229 0.00148454597105781 no 40 0.00278949574757152 17 17612295
SGTC_610 4215-0184 155 µM 2.76765492242141 0.00150487036810385 no 41 0.00282306016223473 38 5605015
SGTC_1765 st044815 90.4 µM 2.74655640959825 0.00161940647939314 no 42 0.00301122641862196 26 645695
SGTC_2396 5342950 42.78 µM 2.74553626317868 0.00162514070738498 no 43 0.00302060452584622 67 1886677
SGTC_2357 9067248 200 µM 2.73968123102946 0.00165841104015053 no 44 0.0030749399384215 17 9150235
SGTC_1134 3477-0009 42.5 µM 2.73452315766301 0.00168823373047375 no 45 0.00312353504617503 36 3973534
SGTC_2129 girgensonine 121.053 µM 2.72035110465422 0.00177270404252812 no 46 0.0032606316623273 48 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1496 4469-0713 57.4 µM 2.68493681815162 0.00200085362712213 no 47 0.00362717591826303 17 746691
SGTC_3174 9107204 49.47 µM 2.67679170304838 0.00205696174102441 no 48 0.00371654150124586 9 3938802
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 2.66607031580082 0.00213299272797883 no 49 0.0038371819799234 20 6857784
SGTC_2586 curcumin 80 µM 2.64671792370474 0.00227671091520397 no 50 0.00406385588112584 35 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2876 9059903 25.97 µM 2.64358310720742 0.00230079973745871 no 51 0.00410168121987596 16 6916095
SGTC_3242 9133940 49.47 µM 2.60249749922338 0.00263856254028028 no 52 0.00462737450663152 17 17248444
SGTC_3155 9099265 49.47 µM 2.59754598693824 0.00268215722161568 no 53 0.00469462733935628 30 25236499
SGTC_3219 9131112 49.47 µM 2.57554726980583 0.00288380969248158 no 54 0.00500407961707746 44 17612988 YMR079W SEC14
SGTC_1465 k213-0056 144 µM 2.56595088745175 0.0029759812861781 no 55 0.0051446697844584 37 24048857 YMR208W ERG12
SGTC_1559 coumarin 343 70.1 µM 2.53257092676423 0.00331762769792288 no 56 0.00566147298997236 17 108770 A hepatotoxic, DNA x-linker.
SGTC_1680 diphenhydramine 100 µM 2.52881799014043 0.00335816532682784 no 57 0.00572236800580649 35 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1499 4480-0877 67.3 µM 2.49119791417123 0.00378980210601404 no 58 0.00636565897008292 15 2861909
SGTC_797 k781-0471 270 µM 2.46781776096429 0.00408250005035692 no 59 0.00679697537620438 32 23738129
SGTC_1171 0368-0077 21.4 µM 2.41900640144428 0.00475963005287993 no 60 0.00778148316372943 52 3239779
SGTC_1084 voriconazole 435 nM 2.41418811752707 0.0048316224552812 no 61 0.00788515889931234 40 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2246 7293507 91.5585 µM 2.41357386689267 0.00484086970164199 no 62 0.00789846275460194 45 887656
SGTC_2344 7990960 76.95 µM 2.40722571537548 0.00493736608227604 no 63 0.00803711582499146 75 140813
SGTC_1153 4055-0057 267 µM 2.39456322921902 0.00513497775988009 no 64 0.00832008705089228 39 882706
SGTC_694 1315-0438 43.2 µM 2.39005897316589 0.00520695084573626 no 65 0.00842283380630762 17 6793154
SGTC_1267 0828-0272 9.49 µM 2.38986364595918 0.00521009216810243 no 66 0.00842731450986941 27 745334
SGTC_1156 4092-0367 4.88 µM 2.38361379574568 0.00531149880036867 no 67 0.00857179161113919 39 1357585
SGTC_3194 9111903 49.47 µM 2.38200028027375 0.00533796226037842 no 68 0.00860944217326837 24 17087251
SGTC_106 0092-0003 11.579 µM 2.37711963324262 0.00541872543520132 no 69 0.00872421403864835 30 1072148
SGTC_2226 7298446 200 µM 2.36959604347576 0.00554535150067359 no 70 0.0089037646893159 18 3283010
SGTC_1679 SEC14.276 6.7 µM 2.35201197549684 0.00585160493384641 no 71 0.00933608688886992 69 1005053 YMR079W SEC14
SGTC_2522 biochanin a 4.94 µM 2.34728442342282 0.00593646097764874 no 72 0.00945540643570757 31 5280373 A possible chelator.
SGTC_1293 1000-1278 195 µM 2.34255069996483 0.00602251930576666 no 73 0.00957621580630935 37 678847
SGTC_3170 9103054 49.47 µM 2.33642919185064 0.00613544600704075 no 74 0.00973444200027692 33 16432970
SGTC_879 0831-1030 162 µM 2.33255288163904 0.0062079207189631 no 75 0.00983581218951156 60 1549252
SGTC_2290 7904846 200 µM 2.33004955414296 0.00625512699326226 no 76 0.0099017660929222 41 2962154
SGTC_645 0845-0943 5.41 µM 2.32894621508998 0.00627603383880783 no 77 0.00993095760129317 33 1885106
SGTC_402 epigallocatechin gallate 10 µM 2.32133000483351 0.00642204635916704 no 78 0.0101345200201734 44 65064 An antioxidant.
SGTC_1622 st003707 19.4 µM 2.31924556220201 0.00646252813826998 no 79 0.0101908626442292 38 10140899
SGTC_2820 7989630 71.43 µM 2.31642270081383 0.00651771050097549 no 80 0.0102676002368763 14 2984098
SGTC_1628 st004252 77.7 µM 2.29901242106256 0.00686735650843988 no 81 0.0107521169988839 32 692968
SGTC_2905 7799065 20.05 µM 2.29896027236102 0.00686842821044909 no 82 0.0107535976643687 37 1296806
SGTC_3127 9126946 49.47 µM 2.28959390730143 0.00706332747492099 no 83 0.011022434257814 40 27243249
SGTC_2381 9035592 200 µM 2.279788074761 0.00727258496341377 no 84 0.011310130312047 31 4749657
SGTC_2488 5268135 45.7 µM 2.26720726787984 0.00754905422012201 no 85 0.0116887835309241 48 1270356 YLR208W SEC13
SGTC_604 1000-0114 314 µM 2.25562172553558 0.00781179641703514 no 86 0.0120471657120483 29 1572745
SGTC_1395 3486-0190 4.35 µM 2.24864693414713 0.00797382486614497 no 87 0.0122674839194986 32 6748079
SGTC_2245 6637752 200 µM 2.24645267241975 0.00802540628324896 no 88 0.012337513879221 33 681890
SGTC_910 3454-3003 490 µM 2.2306453935145 0.00840574019630467 no 89 0.0128523137079826 47 820824
SGTC_3144 9087057 49.47 µM 2.22478139678284 0.00855080433846492 no 90 0.0130479584248215 32 17249618
SGTC_3175 9106517 49.47 µM 2.22301401892095 0.00859495452556928 no 91 0.013107427341426 35 41468073
SGTC_1567 st069303 68.4 µM 2.21826091781325 0.00871468341904714 no 92 0.0132685236430999 56 5581319
SGTC_570 0987-0065 62.6 µM 2.21597260278168 0.00877284496358175 no 93 0.013346689269308 31 3104428
SGTC_284 0988-0104 32.6 µM 2.21476628684153 0.00880364236123919 no 94 0.0133880551801408 24 4666532
SGTC_1864 st057645 30.4 µM 2.21116756014208 0.00889608206565692 no 95 0.0135121179486089 33 688666
SGTC_2709 st078560 56 µM 2.1996530986698 0.00919758989402238 no 96 0.0139157583938278 44 17250903
SGTC_2797 7859098 81.82 µM 2.19314842864974 0.00937183901090255 no 97 0.0141483433855039 38 972681
SGTC_3181 9108277 49.47 µM 2.18507333773538 0.00959216956640672 no 98 0.0144417349009751 48 17097298
SGTC_328 k915-0120 63.5 µM 2.16909428278104 0.0100415387950801 no 99 0.0150377633334675 22 6624543
SGTC_7 0192-1582 4.227 µM 2.16515257098134 0.0101551746280512 no 100 0.0151880015674846 52 252616
SGTC_1686 st019653 115.5 µM 2.1624933076166 0.0102324709640925 no 101 0.0152900861927019 37 97252
SGTC_3061 glucosamine 200 µM 2.14522136571584 0.0107471126756691 no 102 0.0159675760586947 28 91431 and experimental redox chemotherapeutic
SGTC_1555 citronellol 128 µM 2.13995944087832 0.0109083133172063 no 103 0.0161790223381891 28 8842 A terpine precursor.
SGTC_3244 9134489 49.47 µM 2.13436665753982 0.0110819526545181 no 104 0.0164063893542993 46 16584271
SGTC_726 3448-4391 34.2 µM 2.1320226318858 0.0111554395810963 no 105 0.0165024930410282 38 1356692
SGTC_1447 4239-0816 81.9 µM 2.12755275251948 0.0112967486233525 no 106 0.016687091560787 49 1341554
SGTC_1737 st035557 69.7 µM 2.12108112382881 0.0115040960496595 no 107 0.0169574880756587 45 5716916
SGTC_234 nsc-17383 10.7 µM 2.11752214842474 0.0116195263315361 no 108 0.0171077787986501 46 408974
SGTC_2866 9034245 58.44 µM 2.10595693665744 0.0120015980003278 no 109 0.017604046590594 18 6462273
SGTC_3101 9120531 49.47 µM 2.08155057209517 0.012843792434402 no 110 0.0186917701081507 52 24824904
SGTC_411 enrofloxacin 100 µM 2.07797747072746 0.0129712832106297 no 111 0.0188557171190762 25 71188 A bacterial gyrase inhibitor.
SGTC_2884 9058502 51.95 µM 2.07163029135062 0.0132004543712211 no 112 0.0191499663823709 42 6471554
SGTC_799 1310-0557 151 µM 2.05726285978721 0.0137321613188116 no 113 0.0198304739328471 58 5354492
SGTC_250 brefeldin a 552.239 µM 2.0475056226205 0.0141037012521017 no 114 0.0203042326869833 20 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_3114 9122766 49.47 µM 2.03863846053374 0.0144488297815513 no 115 0.0207430618824631 45 17176985
SGTC_351 caspofungin 25 nM 2.03810770726352 0.0144697164684394 no 116 0.0207695812774428 85 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1092 toremifene 6.32 µM 2.03074889905823 0.0147619961474321 no 117 0.0211402365917494 46 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1621 st003705 32.4 µM 2.0300967884148 0.0147881401458329 no 118 0.0211733509610488 50 24207032
SGTC_636 0kpi-0074 126 µM 2.02600374837295 0.014953146747367 no 119 0.0213822002640603 41 616434
SGTC_2627 acetyl isogambogic acid 100 µM 2.01978388086896 0.0152069234572454 no 120 0.0217029049256821 56 6857789 A caspase activator and apoptosis inducer.
SGTC_2882 9058044 58.44 µM 2.0100101530851 0.0156131743759117 no 121 0.0222150571414917 50 18076804
SGTC_2924 9010168 62.78 µM 1.99432919721754 0.0162844155162643 no 122 0.0230580452406197 45 2993929
SGTC_541 4513-1321 94 µM 1.98514080168397 0.0166891057033165 no 123 0.0235644041899255 67 747515
SGTC_2960 9079389 5.97 µM 1.98131143112302 0.0168602882538653 no 124 0.0237781796193604 38 16457355
SGTC_1573 oleylamine 1.06 µM 1.9785374531813 0.0169852279567269 no 125 0.0239340538789211 47 5356789 An amine of the fatty acid oleic acid.
SGTC_253 dyclonine 31.25 µM 1.96942574843161 0.0174012029654121 no 126 0.0244521106894191 55 3180 An oral anasthetic.
SGTC_843 0310-0051 143 µM 1.96480002043129 0.0176156893019863 no 127 0.0247186939235749 45 2065037
SGTC_1740 st038286 13.222 µM 1.96375701974058 0.0176643618219095 no 128 0.0247791383070812 57 716786
SGTC_2098 5376439 882.5 nM 1.94983570561609 0.0183250788592038 no 129 0.0255978521656831 40 2844116
SGTC_1656 st012921 11 µM 1.94405821357033 0.0186054025017442 no 130 0.0259442157626681 47 6732821
SGTC_3162 9099653 49.47 µM 1.93639076418423 0.0189830573303796 no 131 0.026409929896786 39 25237511
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.924478993099 0.0195826874030128 no 132 0.02714728568898 34 77254
SGTC_3312 9133330 71.43 µM 1.92248959179988 0.0196843838186378 no 133 0.0272720910008504 51 17617324
SGTC_1673 st016611 27.3 µM 1.92090052825687 0.019765937116805 no 134 0.0273721245832196 60 5226799
SGTC_1024 4507-0395 26 µM 1.92025411187738 0.0197991942148899 no 135 0.0274129047860486 54 4201836
SGTC_1246 0422-0085 105 µM 1.91202040523323 0.0202269772997927 no 136 0.0279367884219654 73 264295
SGTC_932 2857-0803 154 µM 1.90513635291309 0.0205906297771045 no 137 0.0283811744992323 56 674898
SGTC_1322 1348-1070 12 µM 1.89888645481919 0.0209255645930465 no 138 0.0287897033241073 48 6758089
SGTC_1877 wortmannin 25 µM 1.89597688175094 0.0210830562081906 no 139 0.0289815507795895 61 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.89119590220455 0.0213440224023721 no 140 0.029299099084424 62 688664
SGTC_109 0132-0036 33.701 µM 1.88632593922393 0.0216126485685384 no 141 0.0296255229410617 50 67274 A color developer.
SGTC_1360 1598-0022 39.8 µM 1.88242740251332 0.0218297448433257 no 142 0.0298890041158886 71 761525
SGTC_232 clozapine 119 µM 1.8775683596408 0.0221029041001168 no 143 0.0302201187696185 50 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_139 0099-0334 718.624 µM 1.87298644505114 0.022363121429828 no 144 0.0305351284037171 65 97690
SGTC_2801 7907800 81.82 µM 1.87252579614087 0.0223894251054455 no 145 0.0305669482411923 61 6620925
SGTC_2352 9027995 87.8 µM 1.87049510773511 0.022505691442337 no 146 0.0307075478703232 46 2997347
SGTC_1249 0481-0015 10.2 µM 1.86726141503661 0.0226918860261397 no 147 0.0309325454372388 66 4227577
SGTC_1971 st069429 63.5 µM 1.86164559064218 0.0230183279470076 no 148 0.0313265312754173 39 1246522 YGL099W LSG1
SGTC_2567 aureobasidin a 60 nM 1.84255910918473 0.0241575152167681 no 149 0.0326967044064077 129 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1757 st041620 31.8375 µM 1.83903197067568 0.0243731363044798 no 150 0.0329552419178895 41 5289815
SGTC_3227 9130768 49.47 µM 1.83695606299117 0.0245007944224434 no 151 0.0331081909383398 44 17720899
SGTC_1392 3455-1037 33.9 µM 1.83483361806761 0.0246318940918461 no 152 0.0332651729067702 65 981132
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.83227362224485 0.0247908031436888 no 153 0.0334553324799466 68 688662
SGTC_63 0099-0242 26.702 µM 1.83226391196769 0.02479140753209 no 154 0.0334560554712212 89 3898502 YLR359W ADE13
SGTC_1991 st073000 8.92 µM 1.83163966142174 0.0248302881650301 no 155 0.0335025618571235 89 4301969 YIL048W NEO1
SGTC_1610 st001799 48.1 µM 1.82606343611477 0.0251798701387952 no 156 0.0339203535095263 50 621897
SGTC_1489 4065-0444 182 µM 1.8222554854593 0.0254209588059172 no 157 0.0342081145576079 48 2877968
SGTC_3129 9127257 49.47 µM 1.82124183894885 0.025485459569894 no 158 0.0342850515638516 59 837894
SGTC_1666 st014829 29 µM 1.80439989897001 0.0265773650998039 no 159 0.0355843194470589 56 3858230
SGTC_2189 6047310 154.431 µM 1.78802279382682 0.0276763435719788 no 160 0.0368861652138056 56 711535
SGTC_10 0279-0212 42.575 µM 1.78771451432339 0.027697388331153 no 161 0.0369110394148456 55 39851 YBR002C RER2
SGTC_1186 1319-0216 26 µM 1.78300456215082 0.0280205758486922 no 162 0.0372927803433427 68 4565136
SGTC_2781 5567276 71.43 µM 1.77201300293434 0.0287870252756878 no 163 0.0381961993977781 83 2853274
SGTC_1927 st060202 13.8 µM 1.77078931033229 0.0288734224409924 no 164 0.0382978721008585 62 688887
SGTC_2288 7946289 167.31 µM 1.77005703411643 0.0289252268232766 no 165 0.0383588200493799 59 1246052
SGTC_293 4049-0273 38.5 µM 1.76410898833324 0.0293488859779958 no 166 0.0388568157363436 71 1380311
SGTC_55 0767-0285 6.563 µM 1.76257781523491 0.0294587763615521 no 167 0.0389858607321285 65 3116166
SGTC_607 4491-0986 66.8 µM 1.76192556459884 0.0295056912159419 no 168 0.0390409373293999 52 698981 YDR232W HEM1
SGTC_1388 3346-4487 254 µM 1.76004744211848 0.0296411266779171 no 169 0.0391998814852158 65 3345614
SGTC_2983 9022671 12.99 µM 1.75986506422877 0.0296543057784851 no 170 0.0392153440096006 64 6405161
SGTC_1202 1988-0068 29.6 µM 1.75734512712275 0.0298369012879909 no 171 0.0394295001338276 66 2850480
SGTC_2034 5197015 53.07 µM 1.75561325191495 0.0299629335553287 no 172 0.0395772339612742 75 780676
SGTC_1023 4482-3888 16 µM 1.75276976978233 0.0301708171696318 no 173 0.0398207670743718 75 3303168
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.75155803792872 0.0302597680434672 no 174 0.0399249166736032 68 688664
SGTC_2879 9041815 71.43 µM 1.74103484249644 0.0310414315961244 no 175 0.0408387356390685 35 4942971
SGTC_1494 4358-1428 177 µM 1.7306072337882 0.0318324015656109 no 176 0.0417609203125726 75 1564571
SGTC_1978 st071761 42 µM 1.72721689163893 0.0320931296358154 no 177 0.0420643591552702 78 5147680
SGTC_2505 galangin 7.89 µM 1.72517506251244 0.0322510016936691 no 178 0.0422479641809516 80 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.72474394538959 0.0322844170343827 no 179 0.0422868138142118 74 390807
SGTC_255 tunicamycin 200.472 nM 1.71584556888512 0.032980524208815 no 180 0.0430951556469807 83 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1324 1418-0026 34.4 µM 1.70889653379171 0.0335326985011668 no 181 0.0437350583505945 64 1372513
SGTC_1088 bifonazole 369 nM 1.70099510267136 0.0341697734496653 no 182 0.0444719534018444 61 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_420 mitomycin C 81.9 mM 1.69632170965882 0.0345512392620839 no 183 0.0449124856426882 91 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2068 5226020 147 µM 1.69522763725841 0.0346410464763022 no 184 0.0450161229992185 84 1810509
SGTC_2912 7964298 10.93 µM 1.69437164059123 0.0347114447867206 no 185 0.0450973424774874 109 2975850
SGTC_198 3454-2873 16.191 µM 1.69347257114566 0.0347855119172919 no 186 0.0451827757607344 81 710957
SGTC_1568 digitonin 820 nM 1.68919038667043 0.0351400697586772 no 187 0.0455914753364285 104 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2645 abamectin 100 µM 1.68657822261336 0.0353578049647952 no 188 0.0458422411718179 78 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_519 k048-0011 62.8 µM 1.68298743597577 0.0356589172829661 no 189 0.0461887618312898 67 6836379
SGTC_1615 st002656 86.5 µM 1.68058694587434 0.0358613847703445 no 190 0.0464215865831043 69 1584458
SGTC_1752 st044819 83.042 µM 1.67891693271704 0.03600279554075 no 191 0.0465841170013878 80 441209 YML126C ERG13
SGTC_3012 9080433 71.4286 µM 1.67861101544992 0.0360287489558704 no 192 0.0466139391670162 87 17688859
SGTC_3251 9135047 49.47 µM 1.67552365121762 0.0362915334359985 no 193 0.0469157673041428 58 17682963
SGTC_212 3807-4682 38.772 µM 1.67460078478147 0.0363703881498468 no 194 0.0470062926006987 85 3125501 YBL034C STU1
SGTC_2705 st078069 42.8 µM 1.67323407950987 0.0364874244242301 no 195 0.0471406119318661 74 1530061
SGTC_2752 diclazuril 33.15 µM 1.66982510339984 0.0367806916786472 no 196 0.0474769860583271 83 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1658 st012944 20 µM 1.6697127584404 0.0367903892008176 no 197 0.04748810412551 84 24207260
SGTC_2825 7998094 58.44 µM 1.66197066806013 0.037463733583379 no 198 0.0482593279211746 90 2987815
SGTC_2581 avocatin a 64 µM 1.66131408108842 0.0375212982030722 no 199 0.0483251917209982 74 6710728 A skin care supplement.
SGTC_1299 1079-1439 3.74 µM 1.66128458873213 0.0375238855656841 no 200 0.0483281518559159 86 323161
SGTC_2108 5365811 200 µM 1.65771724988871 0.0378379242456309 no 201 0.0486872752052806 83 780283
SGTC_2363 9053361 176 µM 1.65601728823075 0.0379883274552162 no 202 0.0488591589041849 85 6469797 YMR079W SEC14
SGTC_2910 7948405 25.97 µM 1.6496683103739 0.0385543678967594 no 203 0.0495053975313729 66 2971328
SGTC_916 4466-0038 42 nM 1.64629674224898 0.0388577415413402 no 204 0.0498513399392803 112 5722064 YGL116W CDC20
SGTC_745 0469-0705 296 µM 1.64188322790579 0.0392578048264189 no 205 0.0503071031791236 118 3486736
SGTC_2361 9034121 116 µM 1.64027047127145 0.0394048268776227 no 206 0.0504744712201896 115 6496917
SGTC_893 0958-0369 48.9 µM 1.63891938088915 0.0395283394748537 no 207 0.0506150254048553 80 6819948
SGTC_628 1636-0253 16 µM 1.63783069440186 0.0396280928390314 no 208 0.0507285083268969 91 4456143
SGTC_108 0509-0257 621.132 µM 1.63508125446274 0.0398809280531587 no 209 0.0510160076278048 95 536624
SGTC_685 1278-0033 54.9 µM 1.63117987693563 0.0402419427824219 no 210 0.0514261850419771 90 3590572
SGTC_3125 9127534 49.47 µM 1.62131607171725 0.0411665409944298 no 211 0.0524749349762681 58 1639235
SGTC_1192 1488-0095 21.4 µM 1.62049093318084 0.04124466096834 no 212 0.0525634302127924 71 915875
SGTC_2665 lovastatin 100 µM 1.61962598404545 0.0413266789813299 no 213 0.0526563222115809 74 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_3237 9133362 49.47 µM 1.61918637613548 0.0413684150419207 no 214 0.0527035842076946 76 43845137
SGTC_1614 st002383 48.6 µM 1.61298773145648 0.041960554758124 no 215 0.0533735866190239 60 1947235
SGTC_2954 9074818 52.69 µM 1.61039225637322 0.0422105229547833 no 216 0.0536561250138409 95 16648742
SGTC_2661 dactinomycin 12.96 µM 1.60820544622635 0.0424220670301627 no 217 0.0538950953897906 72 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1140 3229-1848 2.98 µM 1.60542581803489 0.0426921950128326 no 218 0.0542000631881462 68 2849525
SGTC_2411 st077133 39.94 µM 1.60512564631159 0.0427214491077903 no 219 0.0542330781585255 98 1403142 YNL221C POP1
SGTC_2163 5671233 125 µM 1.60429774144924 0.0428022189368539 no 220 0.0543242193582041 100 701023
SGTC_2828 7998861 71.43 µM 1.60381039172265 0.0428498221233806 no 221 0.0543779266482783 52 2988188
SGTC_646 4092-0839 27.3 µM 1.60078701067708 0.0431460958035782 no 222 0.0547120507665274 95 877796
SGTC_72 0744-0168 198.391 µM 1.59990534479423 0.0432328048387798 no 223 0.054809791729059 88 677577
SGTC_1362 1611-0397 101 µM 1.59913976900747 0.0433082108854977 no 224 0.0548947749225226 94 27816
SGTC_3139 9095020 49.47 µM 1.59521348208184 0.0436966044406018 no 225 0.0553322524470821 53 25236292
SGTC_2486 5283202 22.39 µM 1.59470961515061 0.0437466504809674 no 226 0.0553885934475643 75 1377751
SGTC_352 k048-0007 5.11 µM 1.59357140216468 0.0438598724874725 no 227 0.0555160320022764 116 6811911
SGTC_757 1066-0008 322 µM 1.59335700907134 0.0438812253457419 no 228 0.0555400621355828 87 6842497
SGTC_2172 5754775 163.918 µM 1.59223101303006 0.0439935086076578 no 229 0.0556664036232016 115 2263357
SGTC_3249 9135183 49.47 µM 1.59221264165344 0.0439953425031425 no 230 0.0556684668478622 81 4902779
SGTC_1211 1056-0033 32.3 µM 1.58846463506487 0.0443707728674292 no 231 0.0560906559279466 75 6741922
SGTC_2212 7123476 200 µM 1.58553027908276 0.0446664997513606 no 232 0.0564229514928258 46 1085715
SGTC_1983 st071813 46.9 µM 1.57716104810577 0.0455186859266277 no 233 0.057379236576535 82 11838595
SGTC_2854 9024559 71.43 µM 1.56705284627513 0.046565318275799 no 234 0.0585511698569037 81 3163529
SGTC_713 1488-1073 324 µM 1.56681009181539 0.0465906892777483 no 235 0.0585795439023551 83 3312542
SGTC_986 1493-0483 84 µM 1.5658214064504 0.0466941343857046 no 236 0.0586952166611423 81 40079
SGTC_2948 9070189 9.45 µM 1.56369443953357 0.0469173013461058 no 237 0.0589446721061727 74 6473636 YDL196W YDL196W
SGTC_319 1348-1596 45.5 µM 1.56084511078733 0.0472176000170601 no 238 0.059280150396816 99 5380505
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.55648605683593 0.0476799921520558 no 239 0.0597962778444931 106 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_827 3253-0474 693 µM 1.54674742323596 0.0487261323063224 no 240 0.0609620813985166 106 5402065
SGTC_674 0498-0004 451 µM 1.53972435839436 0.0494918862111019 no 241 0.0618137783626313 130 4231473
SGTC_1066 ketoconazole 628 nM 1.53883658685018 0.0495893637442455 no 242 0.0619220977079168 94 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_3341 9147222 25.867 µM 1.53876179514359 0.0495975828845589 no 243 0.061931230002591 90 1939759
SGTC_2711 st079103 59.1 µM 1.53485890762544 0.0500279964192221 no 244 0.0624092445904111 70 54693780
SGTC_2440 5628896 157.78 µM 1.53057925031729 0.0505033784172459 no 245 0.0629367065910803 83 5522048
SGTC_2064 5220758 200 µM 1.52528658932841 0.0510962539635077 no 246 0.0635938156116075 117 788518
SGTC_1669 st015249 58.4 µM 1.52469760020124 0.0511625726822099 no 247 0.0636672703024546 72 722793
SGTC_2379 9035213 200 µM 1.51965779268166 0.0517328468007905 no 248 0.0642985023626099 97 646551
SGTC_2834 9001755 58.44 µM 1.51637345065572 0.0521071944105888 no 249 0.0647124742031831 94 2989575
SGTC_1974 st069448 26.9 µM 1.5161260354365 0.0521354815980145 no 250 0.064743743065968 82 6323587 YNR016C ACC1
SGTC_3002 9075603 71.4286 µM 1.51152531112431 0.0526637116856669 no 251 0.0653273324060495 104 20105405
SGTC_2035 5154463 94.595 µM 1.50982534494127 0.052859963730768 no 252 0.0655439980351253 117 2769623
SGTC_1774 st048371 48.465 µM 1.50792591412382 0.053079928659721 no 253 0.0657867447020354 128 4242727
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.49717435308615 0.0543387336915949 no 254 0.0671739484503144 95 91467 include heat shock
SGTC_179 1273-0063 6.77 µM 1.49544713279303 0.0545431426540601 no 255 0.0673988937655703 69 3108139
SGTC_565 1418-0001 44.5 µM 1.49432652964738 0.0546760860543141 no 256 0.0675451471393697 104 2862145
SGTC_2096 5468907 200 µM 1.4932546650241 0.0548034869296042 no 257 0.0676852688491908 95 759785
SGTC_1965 Pectolinarigenin 58.4 µM 1.49269758959202 0.054869793027039 no 258 0.0677581823108132 81 5320438 An anti-inflammatory.
SGTC_773 4358-1457 44.6 µM 1.49268093002124 0.0548717769142589 no 259 0.0677603637519428 119 1186886
SGTC_2696 st077691 74.316 µM 1.48846713037177 0.0553753960589152 no 260 0.0683138721641253 104 757133
SGTC_1571 st070080 73.4 µM 1.48547072844349 0.0557357312370112 no 261 0.0687095859203056 75 4315245
SGTC_1416 3966-0321 25.3 µM 1.48351227509293 0.0559722450914965 no 262 0.068969178781088 100 582530 YLR208W SEC13
SGTC_38 0929-0051 58.268 µM 1.48207081398922 0.0561468292809031 no 263 0.0691607268369901 99 1379719
SGTC_3215 9129942 49.47 µM 1.47995905084361 0.0564033728680541 no 264 0.0694420875620373 101 17682944
SGTC_1276 0871-0068 94.2 µM 1.47513671934981 0.056992668375608 no 265 0.0700878951056752 119 3414906
SGTC_2434 5670830 169.91 µM 1.47264420968995 0.0572991510589013 no 266 0.0704234986705637 101 1549830
SGTC_563 tetrahydrosecaminediol 614 µM 1.47212146682128 0.0573635925217472 no 267 0.0704940397738421 78 334274 A psychoactive constituent of the cannabis plant.
SGTC_3320 9137005 35.139 µM 1.4696702909866 0.0576665237030736 no 268 0.070825536368061 120 4908713
SGTC_1215 3852-0577 11.2 µM 1.46964349968283 0.0576698416716829 no 269 0.0708291662245774 93 2884876
SGTC_75 0159-0059 199.013 µM 1.46527712405316 0.058212604316421 no 270 0.0714226625770397 120 5377270
SGTC_3231 9132313 49.47 µM 1.46413344525502 0.0583554305873159 no 271 0.0715787452942774 94 4905967
SGTC_444 curcumin 90.4 µM 1.46239682132429 0.0585728318378447 no 272 0.0718162499966624 106 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1062 mesoridazine 14.2 µM 1.46045081997582 0.0588171991850855 no 273 0.0720831072302998 98 4078 A neuroleptic.
SGTC_984 1492-0255 2.91 µM 1.45788097563809 0.0591411301169207 no 274 0.0724366766435113 93 1585198
SGTC_1493 4348-0038 111 µM 1.45713765031077 0.0592350872988352 no 275 0.0725391936394932 139 800424
SGTC_2418 pentamidine 31.67 µM 1.45442710063882 0.0595786958769902 no 276 0.0729139654634608 113 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3269 9137823 49.47 µM 1.45428359539172 0.0595969310724491 no 277 0.0729338483289129 68 17682936
SGTC_1976 st070609 63.5 µM 1.45184159499286 0.0599079067340936 no 278 0.0732728276508138 96 682556
SGTC_2977 9011197 71.43 µM 1.45091887596656 0.0600257403604964 no 279 0.0734012255444857 101 2704722
SGTC_2616 abietic acid 100 µM 1.44283050693949 0.0610664292812872 no 280 0.0745341115547271 105 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.4420901105147 0.0611623925319883 no 281 0.0746384772855036 105 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1201 1889-3372 45.9 µM 1.43957402202871 0.0614893852961162 no 282 0.0749939768469208 100 5392199
SGTC_3199 9111318 49.47 µM 1.43772212232322 0.0617309307068347 no 283 0.0752564568081397 98 8548020
SGTC_1204 4049-0315 18.3 µM 1.43700210079422 0.0618250436950445 no 284 0.0753586983102879 95 588402
SGTC_1036 k216-0215 33.5 µM 1.43107614651463 0.0626038764140021 no 285 0.076204196410518 87 622330
SGTC_2913 7966556 36.57 µM 1.43050874754806 0.0626788475816928 no 286 0.0762855285020643 104 2976516
SGTC_2116 5511452 16.8835 µM 1.43035280745681 0.0626994644035011 no 287 0.0763078928317814 112 870744
SGTC_1096 rimcazole 32.2 µM 1.42857511505663 0.0629348666244824 no 288 0.0765631954025383 87 18528119 A dopamine reuptake inhibitor.
SGTC_2863 9028737 58.44 µM 1.42634865651551 0.0632306650083854 no 289 0.0768838631291291 89 6460917
SGTC_1652 st011932 78 µM 1.42436392176811 0.0634952605112381 no 290 0.0771705761867221 113 1551076
SGTC_967 1306-0166 352 µM 1.42331416086505 0.0636355576947272 no 291 0.07732255185213 121 4437607
SGTC_1292 0kpi-0043 232 µM 1.41918484064977 0.0641897696314552 no 292 0.0779225671764119 103 3333905
SGTC_659 k018-0002 107 µM 1.41892520257132 0.0642247416317799 no 293 0.0779604118992738 109 6797879 YHR007C ERG11
SGTC_3095 9117207 49.47 µM 1.41662203564467 0.0645356158245358 no 294 0.0782967312146272 65 17015229
SGTC_873 0591-4978 488 µM 1.41547814521349 0.0646904483716826 no 295 0.0784641758870334 111 3305145
SGTC_948 3448-0295 75.3 µM 1.41304821520238 0.065020311409875 no 296 0.0788207739506598 120 678569
SGTC_495 decylubiquinone 155 µM 1.41220874712606 0.0651345721358954 no 297 0.0789442528556783 104 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1735 st034310 56.75 µM 1.40595706026131 0.0659904018063897 no 298 0.0798684379421503 121 871153
SGTC_2047 4141938 200 µM 1.39689319869501 0.0672466475676418 no 299 0.0812228450780597 101 3807862
SGTC_649 1123-0311 367 µM 1.39261870226669 0.0678454693864029 no 300 0.0818675622230267 119 693629 YIL048W NEO1
SGTC_2223 6903751 107.57 µM 1.39188621938408 0.0679484962774239 no 301 0.0819784277504905 102 5598863
SGTC_2972 9093619 59.92 µM 1.39099822682477 0.0680735582319112 no 302 0.0821129822248994 84 25236256
SGTC_2033 5192550 145 µM 1.38957887585152 0.0682738238760016 no 303 0.0823283970099038 102 182073
SGTC_1251 0490-5699 265 µM 1.3892249522093 0.0683238320642118 no 304 0.0823821782022942 121 3883818
SGTC_682 0kpi-0099 17 µM 1.38907889847325 0.0683444771896817 no 305 0.0824043798063472 156 1714895 YML126C ERG13
SGTC_1256 0570-0116 285 µM 1.38869307740334 0.0683990372869212 no 306 0.0824630500714426 114 410638
SGTC_2207 7258803 200 µM 1.38713075065062 0.0686203141485267 no 307 0.0827009483824414 107 3666799
SGTC_1403 3909-7815 62.9 µM 1.38576919699802 0.0688136048157201 no 308 0.0829086954859398 104 6615483
SGTC_594 1487-1584 10.8 µM 1.37972223450511 0.0696771274036319 no 309 0.0838360921331679 127 5013332
SGTC_1917 st066507 28.5 µM 1.37615620753991 0.0701902619570759 no 310 0.084386638431367 128 3156428
SGTC_1742 st038235 28.8875 µM 1.36986862989925 0.0711020887376146 no 311 0.0853639568724919 120 564103 YBR002C RER2
SGTC_687 k029-0044 34.9 µM 1.36922231977411 0.071196330065309 no 312 0.0854648955860981 79 5829338
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.36619751128753 0.0716386659313127 no 313 0.0859384892242017 118 5106787 A p450 inhibitor.
SGTC_1963 st076565 50.3 µM 1.36470177497163 0.0718581740183654 no 314 0.0861734007757689 124 4914280
SGTC_1094 duloxetine 25.4 µM 1.36380483952526 0.0719900517419169 no 315 0.08631449837525 105 60834 A selective serotonin reuptake inhibitor.
SGTC_743 1275-0778 158 µM 1.36365273523202 0.0720124342486344 no 316 0.0863384431419404 142 2849257 YMR203W TOM40
SGTC_1394 3474-0001 65.7 µM 1.36284990838503 0.0721306605275893 no 317 0.0864649091378126 79 5017666 YIL048W NEO1
SGTC_2443 5493264 126.67 µM 1.36015528486606 0.0725285653906563 no 318 0.0868903946260495 110 5340055
SGTC_2909 7941780 10.49 µM 1.35600118016166 0.073145277438329 no 319 0.087549396277772 118 1243215
SGTC_2018 5133068 143 µM 1.35318308211177 0.0735659269236981 no 320 0.0879985743058421 112 785362
SGTC_2747 doxorubicin 7.63 µM 1.35241318330383 0.0736811686090043 no 321 0.0881215872001097 71 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2046 4110841 106 µM 1.34798522032023 0.0743466457079051 no 322 0.0888315681446946 139 44119630 YMR134W ERG29
SGTC_522 1273-0010 11.6 µM 1.34749066164879 0.0744212567840378 no 323 0.0889111294999617 128 5705015
SGTC_1832 st054113 55 µM 1.34391429694656 0.0749625037103763 no 324 0.0894880511303531 102 1251267
SGTC_3283 9109332 35.8195 µM 1.34374169068158 0.074988701688793 no 325 0.0895159653913484 92 17027281
SGTC_2053 5265679 138 µM 1.3419377553066 0.0752629189201531 no 326 0.0898080893393545 136 764595
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.33679299986597 0.0760491751608892 no 327 0.0906451074005481 83 4000243
SGTC_875 0709-0210 25.7 µM 1.33584535385711 0.0761946803743535 no 328 0.0907999126774543 128 6251364
SGTC_2741 miltefosine 3.04 µM 1.33491154351485 0.0763382683849549 no 329 0.0909526496109417 82 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_612 0302-0167 22.4 µM 1.33444929551936 0.0764094224205635 no 330 0.0910283268238307 129 235821
SGTC_226 1,3-diallylurea 8.28947 mM 1.33411462631277 0.0764609696810863 no 331 0.0910831465390357 113 74537 YKL182W FAS1
SGTC_925 2064-1272 59.6 µM 1.3334925230349 0.0765568591224607 no 332 0.0911851137817656 129 6815817
SGTC_3171 9103192 49.47 µM 1.33256554239395 0.0766999112551008 no 333 0.0913372096410694 101 13018434
SGTC_575 k072-0246 11.9 µM 1.33157192133596 0.0768534729896141 no 334 0.0915004483905732 121 6796779
SGTC_2995 9067767 71.4286 µM 1.32690989656831 0.0775771002385235 no 335 0.0922692451146154 90 11673567
SGTC_3030 9087619 49.47 µM 1.32515994848659 0.0778500539716027 no 336 0.0925590531203591 136 25236973
SGTC_542 3381-0244 89.3 µM 1.32412967125459 0.0780110952747795 no 337 0.0927299914363642 120 1112843
SGTC_136 0097-0015 404.482 µM 1.32162373368578 0.0784038500390218 no 338 0.093146738093582 131 4861337
SGTC_1663 st014140 55.4 µM 1.31924423037756 0.078778174747615 no 339 0.0935437378799698 113 4207120
SGTC_1220 1838-0075 193 µM 1.31538474256982 0.0793881960872091 no 340 0.0941903153082703 111 5529645
SGTC_1876 myriocin 605 nM 1.31309892357916 0.0797511691475973 no 341 0.0945748082711394 137 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1139 k015-0024 46.9 µM 1.31234877648332 0.0798705607581315 no 342 0.0947012408061236 113 2766652
SGTC_750 4073-0104 132 µM 1.3114371848152 0.080015829378583 no 343 0.09485505141805 91 22330957
SGTC_1411 3909-8223 150 µM 1.30864368826879 0.0804622370110703 no 344 0.0953275373909872 138 X1411
SGTC_2933 9026794 32.47 µM 1.30644924347882 0.080814232281057 no 345 0.0956999145017612 120 17586027
SGTC_1407 3909-7909 12.3 µM 1.30533836013323 0.0809928638280816 no 346 0.0958888287080331 118 4411780
SGTC_2138 5575593 77.673 µM 1.30518754633171 0.0810171378503891 no 347 0.0959144968793005 107 762213
SGTC_2596 sinensetin 100 µM 1.30491574402043 0.0810608992720974 no 348 0.0959607697839005 121 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_12 0849-0099 9.267 µM 1.30067216204622 0.0817464509259095 no 349 0.0966853474421506 130 6071388
SGTC_3068 9116768 49.47 µM 1.29674785397323 0.0823843050301316 no 350 0.0973589790546428 135 41904888
SGTC_1747 st037496 66.6 µM 1.29544079252985 0.0825975836682679 no 351 0.0975841067984469 152 723305
SGTC_2923 7992654 58.14 µM 1.29063228166601 0.0833857858008175 no 352 0.0984156082916813 121 2985126
SGTC_863 0466-0191 129 µM 1.2904641705236 0.0834134441968082 no 353 0.0984447721270892 144 765160 YPR165W RHO1
SGTC_1944 st076371 56.9 µM 1.28688786181431 0.0840034693027039 no 354 0.0990666883179184 119 24208455
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.28447096951548 0.0844039829449557 no 355 0.0994886074500464 120 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2588 indole-3-carbinol 100 µM 1.27763819375435 0.0855440215758609 no 356 0.100688513535447 128 3712 Induces cell cycle arrest.
SGTC_1446 4239-0190 62 µM 1.27512923399851 0.0859655196738182 no 357 0.101131751789767 129 1340085
SGTC_2 0422-0095 29 µM 1.27162071887561 0.086557543725907 no 358 0.101753955815929 119 6790840
SGTC_3321 9137793 26.8275 µM 1.27132409643542 0.0866077349447474 no 359 0.10180668665744 151 4904192
SGTC_592 k241-0073 46.5 µM 1.27007644634266 0.0868190869093823 no 360 0.102028700348638 139 4230158
SGTC_95 0471-0001 561.058 µM 1.26528570264832 0.0876342205932944 no 361 0.102884464943312 135 4015405
SGTC_264 promethazine 12.5 mM 1.26499523579968 0.0876838258268109 no 362 0.102936517854129 167 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_3338 9144300 39.5675 µM 1.264586384379 0.0877536839859841 no 363 0.103009818204566 106 4901274
SGTC_2656 pseudo-anisatin 100 µM 1.26352538112598 0.0879351653495686 no 364 0.103200215527509 124 6708809 A neurotoxin.
SGTC_2786 7743617 45.45 µM 1.26234875641873 0.0881367505491398 no 365 0.103411659843475 117 583674
SGTC_1798 st045719 60.953 µM 1.26210774436842 0.0881780844092107 no 366 0.103455009480226 129 3980186
SGTC_2225 6654152 15.4 µM 1.26085914123474 0.0883924527308457 no 367 0.103679800682025 143 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2370 9071495 200 µM 1.25797591966754 0.0888889463047654 no 368 0.104200232538173 138 21791103
SGTC_1430 4049-0248 69.1 µM 1.24925222624759 0.0904038174506846 no 369 0.105786417697892 137 22774488
SGTC_2708 st078559 56 µM 1.24627173039641 0.0909257503881424 no 370 0.106332326348041 98 17250902
SGTC_3265 9137266 49.47 µM 1.24543107536025 0.0910733660581667 no 371 0.106486668208761 101 17224265
SGTC_2190 6049624 200 µM 1.24537819498097 0.0910826575803901 no 372 0.106496382299472 131 2265554
SGTC_1235 benzylparaben 21.5 µM 1.24391656224001 0.0913397569616969 no 373 0.106765136543949 130 7180
SGTC_740 k014-0057 261 µM 1.23840483238892 0.0923141035204425 no 374 0.107782994864481 147 4012779
SGTC_825 1988-2224 89.6 µM 1.23594751543226 0.0927509712247681 no 375 0.108239036687903 152 1180859
SGTC_794 k038-0031 316 µM 1.23477798050844 0.0929594301502455 no 376 0.10845657225956 132 6624242
SGTC_1835 st008666 49.2 µM 1.23146876350286 0.0935511440707902 no 377 0.109073796234996 106 690455
SGTC_2024 5144227 134 µM 1.23084322577435 0.0936633070150258 no 378 0.109190752560532 127 3475211
SGTC_654 1124-0271 80.9 µM 1.22932368338572 0.0939361842524265 no 379 0.10947523552472 143 5403748
SGTC_1796 st049173 110.4 µM 1.22726741249035 0.0943063799724262 no 380 0.10986104974393 140 94134
SGTC_2113 5491891 107.031 µM 1.22721044009115 0.0943166521566126 no 381 0.109871753242978 140 789979
SGTC_813 k007-0158 173 µM 1.22613870019068 0.0945100417959714 no 382 0.110073242269804 139 6523916
SGTC_1588 farnesol 29.9 µM 1.22502272032614 0.0947117248313925 no 383 0.110283330073133 138 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_194 1486-1323 56.904 µM 1.22486355229517 0.0947405159551893 no 384 0.110313317526301 159 5178754
SGTC_1259 0671-0132 43 µM 1.22228616753982 0.0952076246363487 no 385 0.110799714149691 131 X1259
SGTC_901 1112-0062 60.1 µM 1.22128245839102 0.0953899885164481 no 386 0.110989546364038 130 1908457
SGTC_2806 7952793 58.44 µM 1.22125988432505 0.0953940929522614 no 387 0.110993818489859 129 2972490
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.21568692175849 0.0964113557081434 no 388 0.112052104014069 158 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2749 bexarotene 57.39 µM 1.21567751272872 0.0964130799031697 no 389 0.112053896833858 133 82146 An retinoic acid receptor inhibitor.
SGTC_1720 st037298 9.481 µM 1.2146014317609 0.096610420141951 no 390 0.112259071266461 153 597396
SGTC_980 1473-0395 201 µM 1.2129653764206 0.0969110211463968 no 391 0.112571529181033 148 768876
SGTC_2442 5158906 48.48 µM 1.21191423178869 0.0971045154336555 no 392 0.112772606865678 143 1893835
SGTC_161 4065-0411 162.148 µM 1.20807840962845 0.0978130173185844 no 393 0.113508551784557 151 1906281 YLR208W SEC13
SGTC_938 3126-1755 342 µM 1.20320987230695 0.0987177160041807 no 394 0.114447557760861 128 1777771
SGTC_2712 st079126 47.7 µM 1.20081789783328 0.0991644430403626 no 395 0.114910923801543 143 3152970
SGTC_2650 prasterone 100 µM 1.2002697857078 0.0992670167664488 no 396 0.115017290079362 111 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2041 5107442 45.335 µM 1.19832964597646 0.0996307178769953 no 397 0.115394354823289 159 793005
SGTC_458 nppb 133 µM 1.1925419116065 0.100721477324131 no 398 0.116524413581212 120 4549 A chloride channel blocker.
SGTC_1418 3966-3099 2.4 µM 1.19127389169342 0.100961607721512 no 399 0.116773039917324 162 740335
SGTC_1859 st055998 20 µM 1.19117173028789 0.100980972619021 no 400 0.116793087519292 137 676301
SGTC_2021 4019055 173 µM 1.19113982630614 0.100987020636967 no 401 0.116799348684133 184 44827708 YER133W GLC7
SGTC_368 fentichlor 4.58 µM 1.18874502538901 0.101441755673458 no 402 0.117270008446363 150 7329 A pesticide.
SGTC_2611 pyromycin 23.93 µM 1.18863980257503 0.101461769981953 no 403 0.117290719069821 139 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1998 st075797 76.8 µM 1.18688927138345 0.101795158519026 no 404 0.117635649857162 151 24208315
SGTC_1005 4092-0690 4.4 µM 1.18371977998133 0.102400815621987 no 405 0.118262003189182 155 1529343
SGTC_2844 9010103 25.97 µM 1.18011790046095 0.103092273696428 no 406 0.118976663032675 147 2480525
SGTC_1029 k015-0030 64.7 µM 1.17725662054442 0.103643969914389 no 407 0.119546547754252 155 2208316
SGTC_571 k831-0106 44.2 µM 1.17619126017294 0.103849933169548 no 408 0.119759228089931 154 4783639
SGTC_1472 k841-0093 193 µM 1.17500279918979 0.10408004525977 no 409 0.119996797957343 145 X1472
SGTC_840 0245-0196 390 µM 1.17187614974729 0.104687198242632 no 410 0.120623391933381 140 3827528
SGTC_3027 9089541 49.47 µM 1.16766274589301 0.105509436016441 no 411 0.12147141477831 151 9943819
SGTC_1579 chlormadinone acetate 49.4 µM 1.16620138518154 0.105795705825609 no 412 0.121766516333216 154 45114258 A steroidal progestin.
SGTC_256 clotrimazole 625 nM 1.16548307784107 0.105936622577868 no 413 0.121911753051095 140 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_164 4100-3994 89.624 µM 1.16179514735153 0.106662252979962 no 414 0.122659342836285 165 4615967
SGTC_2327 6189656 200 µM 1.1601725430405 0.106982647473603 no 415 0.122989281740105 139 5349088
SGTC_2329 6138490 200 µM 1.15866144168185 0.107281648708929 no 416 0.123297106807614 146 720019
SGTC_951 1171-0579 82.7 µM 1.15793124772085 0.10742634771173 no 417 0.1234460472428 158 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_805 3852-0218 479 µM 1.1560941705359 0.107791014436484 no 418 0.123821320111436 144 6615355
SGTC_2082 5219693 150 µM 1.1544501726542 0.108118109477846 no 419 0.124157827765983 148 2834649
SGTC_1935 st074532 41.6 µM 1.15398903953525 0.108209986181127 no 420 0.124252331257659 159 2829742
SGTC_1630 st005209 31.3 µM 1.15319247052728 0.108368827882989 no 421 0.124415696660175 147 3367314
SGTC_2569 tetrandrine 100 µM 1.151980465082 0.108610832398801 no 422 0.124664550407422 132 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1618 st003135 44.5 µM 1.15134160567967 0.108738551581561 no 423 0.124795863475486 157 1270615
SGTC_1072 oxiconazole 14.9 nM 1.14494101851238 0.110024105723979 no 424 0.126116795418312 164 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2075 5212009 200 µM 1.14242282982962 0.110532859843212 no 425 0.126639153076246 158 780898
SGTC_292 k038-0015 474 µM 1.14147038472739 0.110725722872385 no 426 0.126837114646304 149 46368540
SGTC_446 go6976 132 µM 1.13841165455405 0.111346723338194 no 427 0.127474314884716 145 3501 A protein kinase C inhibitor.
SGTC_1183 1254-0324 198 µM 1.13634870688816 0.111766959773091 no 428 0.12790532683901 132 5799357
SGTC_312 4092-0653 6.84 µM 1.13607649969668 0.111822494833295 no 429 0.127962274660575 183 1148278
SGTC_2639 lactacystin 53 µM 1.13561668259947 0.111916350438808 no 430 0.128058511913351 142 3870 A proteasome inhibitor.
SGTC_203 k066-0004 30.888 µM 1.13062387387185 0.11293908604169 no 431 0.129106717358296 180 6795412
SGTC_2092 5303694 80.6725 µM 1.12575943720552 0.113941924946053 no 432 0.130133678861719 160 1963699
SGTC_2303 7774051 200 µM 1.12462824507242 0.11417603490451 no 433 0.130373299795363 156 2953184
SGTC_2926 9010726 65.15 µM 1.12302969296035 0.114507452868768 no 434 0.130712441927236 147 2994293
SGTC_2182 6325192 200 µM 1.12186073027502 0.114750239769847 no 435 0.130960829891502 155 736248
SGTC_1813 st051246 8.6015 µM 1.12083749262546 0.114963060837118 no 436 0.131178520887701 148 5291959
SGTC_1786 berberine 21.6 µM 1.12003751833924 0.115129641241653 no 437 0.131348887210155 171 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1942 st076330 65.2 µM 1.1197007645959 0.115199815517442 no 438 0.131420649559225 162 24208414
SGTC_2658 polymyxin b sulfate 77.05 µM 1.11850736484421 0.115448746393058 no 439 0.131675181409085 164 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2316 5844804 197.44 µM 1.11789850699578 0.115575895009466 no 440 0.131805171391633 173 776813
SGTC_1425 4048-4433 7.33 µM 1.11655497456911 0.115856818624314 no 441 0.13209232613732 196 23734946
SGTC_145 3737-0113 38.366 µM 1.11535156061287 0.116108855764428 no 442 0.132349899193693 196 6849351
SGTC_1444 4112-3581 28 µM 1.1121543024945 0.116780363617188 no 443 0.133035906073412 162 2877249
SGTC_2255 7941087 197.44 µM 1.10889752773761 0.117467197330858 no 444 0.133737195242996 152 935561
SGTC_3326 9140064 16.379 µM 1.10765895522423 0.117729153885666 no 445 0.134004565906285 148 1868434
SGTC_1138 3761-0006 1.03 µM 1.10510153620405 0.118271352360159 no 446 0.134557797515751 135 12061087
SGTC_1040 k898-0338 155 µM 1.10403632094113 0.118497708718895 no 447 0.13478869120866 171 20969351
SGTC_131 0141-0277 33.849 µM 1.10200563475638 0.118930073760397 no 448 0.135229610965759 180 1547771
SGTC_548 1436-0017 110 µM 1.10131206233505 0.119078001166446 no 449 0.135380431561808 155 9677137
SGTC_1012 4112-3522 18 µM 1.10088884033058 0.119168331140175 no 450 0.135472519801187 156 3112398
SGTC_1760 st045453 10.4495 µM 1.10058544331041 0.119233116145273 no 451 0.135538561912273 175 3323419 YIL048W NEO1
SGTC_3352 9151559 45.5865 µM 1.09848657292913 0.119681973222294 no 452 0.135996038795003 150 17159339
SGTC_527 4476-4215 268 µM 1.0968409869202 0.120034724956531 no 453 0.136355454776034 135 4418754
SGTC_2457 5731572 11.68 µM 1.09612554772475 0.120188316532316 no 454 0.136511917892839 171 2865357
SGTC_2971 9092186 9.93 µM 1.09586342261923 0.12024462459635 no 455 0.136569274119081 143 25236400
SGTC_3247 9135149 49.47 µM 1.09438991949311 0.120561499152134 no 456 0.136892001580946 185 8934436 YOR116C RPO31
SGTC_2115 tiliquinol 12.7705 µM 1.09370437542379 0.120709124580282 no 457 0.137042327341304 166 71208 A bioactive hydroxyquinoline.
SGTC_3044 9093193 49.47 µM 1.0932110185374 0.120815443026839 no 458 0.137150580161685 155 25236277
SGTC_700 3453-2283 142 µM 1.09266281463108 0.120933658296426 no 459 0.137270936066533 157 565664
SGTC_1518 st038567 90.8 µM 1.09198640305463 0.121079632545788 no 460 0.137419538822246 172 77966
SGTC_1810 st050138 53 µM 1.0916248539916 0.121157708123133 no 461 0.137499013579758 195 3444541
SGTC_2891 9063876 19.48 µM 1.08734863665005 0.122083833078236 no 462 0.138441380795495 142 6472478
SGTC_1101 ebselen 5.29 µM 1.0855744128316 0.122469542374559 no 463 0.138833662607225 184 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1797 st048695 56.8 µM 1.08152941511965 0.123352103944986 no 464 0.13973084167717 181 592262 YIL048W NEO1
SGTC_382 3229-0966 23.2 µM 1.07954134286903 0.123787502671397 no 465 0.140173236997257 160 5722370
SGTC_1664 st014217 9.02 µM 1.07540962989647 0.124695808986629 no 466 0.141095686129044 180 3982782
SGTC_3069 9117009 49.47 µM 1.07533676573371 0.12471186896593 no 467 0.141111990685944 150 41904981
SGTC_1926 methyl fluorone black 53.6 µM 1.07065375836689 0.125747083310604 no 468 0.142162571000653 163 72721 Reacts with homocysteine.
SGTC_1370 2001-0092 44.6 µM 1.06942054199624 0.126020689451075 no 469 0.142440107567092 176 790957
SGTC_2135 5326629 150.42 µM 1.06928375139024 0.126051063897162 no 470 0.14247091499397 153 5020077
SGTC_926 2268-1401 59.4 µM 1.06839125474196 0.126249368672145 no 471 0.142672030102975 182 2931578
SGTC_2261 9010538 184.68 µM 1.0683801621272 0.126251834719171 no 472 0.142674530918794 174 6457250
SGTC_432 NS 1619 61.3 µM 1.06779986973669 0.12638088884073 no 473 0.142805398427278 149 4552 A K+/calcium channel activator.
SGTC_1756 st041558 35.5 µM 1.06750983776836 0.126445424937487 no 474 0.14287083682298 172 3955792
SGTC_1816 st051957 91.6 µM 1.06204992708436 0.127664615947423 no 475 0.144106510075527 154 674121
SGTC_1901 st060216 58.6 µM 1.06155878099691 0.127774687491197 no 476 0.144218017239412 163 688792
SGTC_900 1112-0045 141 µM 1.05950538175911 0.12823559236904 no 477 0.144684839788337 165 56211 YIL048W NEO1
SGTC_1174 0739-0097 51.1 µM 1.05578225253325 0.12907422558749 no 478 0.145533854145413 184 728447
SGTC_1780 st038448 24.544 µM 1.05565490530368 0.129102977599195 no 479 0.145562953268947 167 728868 YDL195W SEC31
SGTC_124 0136-0217 7.121 µM 1.0556454983052 0.129105101654495 no 480 0.145565102944068 198 3976905
SGTC_2296 7971656 126.45 µM 1.05340870311099 0.129610847275105 no 481 0.146076858555985 149 666570
SGTC_1413 3910-0535 34.4 µM 1.05244217714321 0.129829805541137 no 482 0.146298363220037 165 2876951
SGTC_2644 guaiazulene 100 µM 1.0511244949812 0.130128727670675 no 483 0.146600707665614 153 3515 A coloring agent.
SGTC_2563 tomatine 8.54 µM 1.05107625831147 0.130139679405859 no 484 0.146611783603314 167 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1290 0986-0249 10.2 µM 1.04918679008148 0.130569169364557 no 485 0.147046078627203 171 53329
SGTC_2312 7706453 155.7 µM 1.0481457415323 0.130806225638177 no 486 0.147285732265538 171 976098
SGTC_862 0452-0056 10.2 µM 1.04720393544056 0.131020939640913 no 487 0.147502765303969 164 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_26 0302-0163 425.158 µM 1.04613933780248 0.131263940849526 no 488 0.147748352709856 199 3100915
SGTC_1898 st060199 18.6 µM 1.04389297922591 0.131777707300243 no 489 0.148267453400924 155 688866
SGTC_278 4092-0821 23.9 µM 1.03812323902286 0.133103661388945 no 490 0.149606341771256 164 877900
SGTC_1257 0669-0121 16 µM 1.03588731780177 0.133619962768041 no 491 0.150127357437233 179 4307855
SGTC_2829 7992743 58.44 µM 1.03379584002817 0.134104155392408 no 492 0.150615808406664 165 16462845
SGTC_748 act1.228 77.9 µM 1.03214291186615 0.134487672283068 no 493 0.151002586933186 158 4421505 YNR035C ARC35
SGTC_2002 4023503 131 µM 1.03213318923752 0.134489930379086 no 494 0.151004863942793 203 4736863 YCR052W RSC6
SGTC_1245 0418-0076 17.2 µM 1.03131511004954 0.134680023814938 no 495 0.151196537412734 166 6790114
SGTC_2309 7664088 163.95 µM 1.03110659610437 0.134728504750461 no 496 0.151245417469562 175 704922
SGTC_3096 9117468 49.47 µM 1.02451621173249 0.136266987610378 no 497 0.15279575877104 156 41316311
SGTC_3260 9137109 49.47 µM 1.02429358602772 0.136319167205669 no 498 0.152848313268381 164 17478346
SGTC_2233 sulbentine 40.3845 µM 1.02390094713168 0.136411228250697 no 499 0.152941031415136 199 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_3053 9095903 49.47 µM 1.02362249679322 0.136476541564461 no 500 0.153006807555284 216 17174018
SGTC_280 3448-3607 3.04 µM 1.01973953128812 0.137389559029941 no 501 0.153926004031715 141 626179
SGTC_2541 muurolladie-3-one 83.07 µM 1.01932244677035 0.137487877287973 no 502 0.154024955412868 209 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1521 st012942 49.4 µM 1.01798277922555 0.137803998530721 no 503 0.154343070000995 170 24207259
SGTC_2325 6158266 200 µM 1.0162783432895 0.138206910500373 no 504 0.154748429241422 164 3623240
SGTC_152 4469-0003 551.229 µM 1.01455416762734 0.138615305174556 no 505 0.155159198122406 206 697280
SGTC_683 panaxydol 45 µM 1.01389448136773 0.138771778162465 no 506 0.155316552482853 149 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1702 st027038 51 µM 1.01307605735739 0.13896606978413 no 507 0.155511916744468 153 5521182
SGTC_633 0437-0093 97.7 µM 1.00991651710497 0.139717873034696 no 508 0.156267644283512 179 2831118
SGTC_2257 7960413 200 µM 1.0098040591296 0.139744682943251 no 509 0.156294587516363 189 2974689 YIL048W NEO1
SGTC_334 1502-1024 68.5 µM 1.00961842141404 0.13978894650577 no 510 0.156339070204417 163 3296216
SGTC_730 1436-0052 41.2 µM 1.00925790245833 0.139874936075972 no 511 0.156425481923363 158 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2095 5432005 200 µM 1.00799664585831 0.140176048919146 no 512 0.156728036228789 183 783734
SGTC_342 k048-0088 23.3 µM 1.00739787086847 0.140319154701181 no 513 0.156871807043806 195 6820570
SGTC_2054 5233173 129 µM 1.00689558635763 0.140439275987191 no 514 0.156992476605435 120 6889
SGTC_814 3342-0569 96 µM 1.00646637833678 0.140541976343434 no 515 0.157095638532923 188 4346283
SGTC_1818 st052136 56.3 µM 1.00521546636185 0.140841583749445 no 516 0.157396554675923 189 674169
SGTC_2048 5246248 200 µM 1.00467408392146 0.140971385153183 no 517 0.157526905623432 175 677046
SGTC_2221 6807166 181.081 µM 1.00066993658063 0.141933935281503 no 518 0.158493203191703 150 674925
SGTC_667 1498-1044 59 µM 0.999868259528181 0.142127182434337 no 519 0.158687133368639 192 6739982
SGTC_1368 1852-0141 284 µM 0.997036561541024 0.142811198389737 no 520 0.159373381770407 182 2838987
SGTC_702 1488-0190 94 µM 0.995737788310945 0.143125669052422 no 521 0.159688782249602 147 949357
SGTC_3342 9147791 14.508 µM 0.995597990250962 0.143159546081466 no 522 0.159722755829018 183 1838168
SGTC_1320 1313-0481 95.3 µM 0.994990930169455 0.143306716756194 no 523 0.15987033779199 160 6813365 YLR208W SEC13
SGTC_2476 5806916 10.51 µM 0.992665669136979 0.143871378941795 no 524 0.160436455319927 181 2870194
SGTC_21 0849-0113 22.993 µM 0.990805916370364 0.144324076806324 no 525 0.160890179898945 194 1560156
SGTC_2254 7938975 95.19 µM 0.99057354429159 0.144380707825202 no 526 0.160946930614811 179 2969277
SGTC_1938 st074717 56.4 µM 0.989777222343182 0.144574891729957 no 527 0.161141510224433 190 17250979
SGTC_3071 9117417 49.47 µM 0.989555194847931 0.144629064709989 no 528 0.161195789532707 180 45595590 YGL055W OLE1
SGTC_3 0833-0587 95.581 µM 0.986225314619861 0.1454431699298 no 529 0.162011279804416 188 5382644
SGTC_1422 4031-0024 15.5 µM 0.985270608654797 0.145677148486655 no 530 0.162245582850654 195 782427
SGTC_886 0866-0150 153 µM 0.982859003870167 0.146269309044417 no 531 0.162838418600127 187 271463
SGTC_936 3005-4620 401 µM 0.981820533589385 0.146524798755794 no 532 0.163094135195025 187 777207
SGTC_1561 5-methoxyflavone 52.9 µM 0.981234878439931 0.146669016618579 no 533 0.163238464031333 171 94525
SGTC_1160 4092-0570 10.5 µM 0.976316520338575 0.147883922861798 no 534 0.164453817852429 194 4994975
SGTC_1791 st048313 56.1 µM 0.97457083179381 0.148316748848043 no 535 0.164886594000981 171 1204976
SGTC_2745 rifampicin 24.3 µM 0.972546405252507 0.148819745262515 no 536 0.165389395277729 127 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2722 naftopidil 47.16 µM 0.972050645801086 0.148943097032591 no 537 0.165512676744272 180 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.971650235193165 0.149042774552198 no 538 0.165612291008301 174 6708514
SGTC_679 0422-0091 41.4 µM 0.97115232730324 0.149166785018651 no 539 0.165736214743979 220 627384 YHR062C RPP1
SGTC_2561 acetosyringone 100 µM 0.969579348349094 0.149559008591789 no 540 0.166128105475454 213 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_259 usnic acid 108.925 µM 0.96900499208742 0.149702396168529 no 541 0.166271349218928 217 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_249 wiskostatin 11.211 µM 0.968918711572043 0.149723943950449 no 542 0.166292874362632 179 2775510 A n-wasp and actin depolymerizer.
SGTC_126 0417-1624 672.48 µM 0.967247022487483 0.150141841658094 no 543 0.166710280234766 237 41912 YDL195W SEC31
SGTC_2785 7756463 72.73 µM 0.96693672739865 0.150219496343482 no 544 0.166787832481716 242 2201551
SGTC_2531 methyl deoxycholate 70.07 µM 0.966770959368061 0.150260992545475 no 545 0.166829272527156 185 16667744 Haematoxylin.
SGTC_922 1866-0035 480 µM 0.963239432868817 0.151146843676266 no 546 0.167713690180231 201 3156169
SGTC_2770 toltrazuril 17.5 µM 0.962796241026353 0.151258259180145 no 547 0.167824893753869 183 68591 Kills coccidiodes.
SGTC_1704 st028805 70.8 µM 0.959588520026155 0.152066287338483 no 548 0.168631174525032 206 2876101
SGTC_552 k242-0005 476 µM 0.959554121135125 0.152074967961138 no 549 0.168639834373578 209 4088318
SGTC_290 2043-6722 48.1 µM 0.956906086124753 0.152744192197994 no 550 0.16930732951772 189 773758 YLR208W SEC13
SGTC_2248 tofa 1.1 µM 0.955699397047202 0.153049799399451 no 551 0.169612063614757 202 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2787 5284540 71.43 µM 0.952777015936712 0.153791602713417 no 552 0.170351530994075 208 736958
SGTC_2311 7694451 200 µM 0.952324947298087 0.153906565858417 no 553 0.170466104753577 226 2163142
SGTC_169 k015-0017 16.025 µM 0.952222862077896 0.153932534471276 no 554 0.170491984395371 211 1840002
SGTC_990 3985-0011 41.3 µM 0.95072531846539 0.154313815415946 no 555 0.170871916072234 199 5399565 YGL099W LSG1
SGTC_1514 1189-1591 158 µM 0.950374975542178 0.154403104268961 no 556 0.170960877344392 213 767698 YMR146C TIF34
SGTC_2178 5812956 200 µM 0.949446661506344 0.154639860724468 no 557 0.171196743913014 208 5403383
SGTC_1817 st052116 64.4 µM 0.949030459380794 0.154746086426588 no 558 0.171302560318081 166 4361398
SGTC_2795 7780010 54.55 µM 0.947946051280758 0.155023082219929 no 559 0.171578459651122 193 953673
SGTC_2857 9024691 58.44 µM 0.947055315376655 0.155250852128287 no 560 0.171805296418091 190 16478292
SGTC_3009 9080819 71.4286 µM 0.946056079630531 0.155506629267805 no 561 0.172059991825677 184 17027216
SGTC_1123 mangostin 811.285 nM 0.945159029973149 0.155736486232326 no 562 0.172288846194974 139 5281650 An antioxidant.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.944175848349139 0.15598867057694 no 563 0.172539897430839 221 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2313 7726885 200 µM 0.942334366135525 0.156461731273964 no 564 0.173010739359497 208 726423
SGTC_122 0236-0016 402.397 µM 0.940824732487219 0.156850246922828 no 565 0.17339734212322 210 6808838
SGTC_14 0354-0009 295 µM 0.940668860370115 0.156890397917021 no 566 0.173437290782356 216 1713507
SGTC_593 1203-0218 61.7 µM 0.939448460321541 0.157204993671795 no 567 0.173750271101296 203 3666956
SGTC_515 4092-1064 102 µM 0.937959763441306 0.157589312430547 no 568 0.174132544169033 215 717353
SGTC_408 cantharidin 100 µM 0.937951490077966 0.157591449987553 no 569 0.174134670126356 180 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_144 4161-2749 112.381 µM 0.937030120406152 0.157829619915031 no 570 0.174371532268739 212 797501 YMR168C CEP3
SGTC_529 4076-0302 30.3 µM 0.935790837371636 0.158150341642766 no 571 0.174690444988581 200 5816522
SGTC_1335 1486-0900 202 µM 0.934785770041964 0.158410763145772 no 572 0.174949357230229 199 X1335
SGTC_1988 st071872 53.4 µM 0.933912739033238 0.158637201087288 no 573 0.175174453521751 180 16414116
SGTC_2292 7671323 168.05 µM 0.933842478537034 0.158655433766294 no 574 0.175192576986287 225 937504
SGTC_3006 9075424 71.4286 µM 0.93370415443614 0.158691333043563 no 575 0.175228260709493 217 7465181
SGTC_387 norethindrone acetate 66.7 µM 0.93234917786055 0.159043271919757 no 576 0.175578050201733 190 541197
SGTC_1319 1306-0155 43.7 µM 0.931920292170589 0.159154776289926 no 577 0.175688859901126 208 3122360
SGTC_465 cgp-37157 41 µM 0.931367289889378 0.159298624825955 no 578 0.175831802553161 173 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_362 0310-0100 9.03 µM 0.929331693307265 0.159828863314359 no 579 0.17635860761105 190 790235
SGTC_2295 7971645 200 µM 0.926713762241865 0.160512485389424 no 580 0.177037585084296 187 2978226 YKL099C UTP11
SGTC_92 0063-0024 660.874 µM 0.926135814270485 0.160663662351693 no 581 0.177187701916215 216 3594437
SGTC_1847 st056231 15 µM 0.925539315331433 0.16081978927393 no 582 0.177342721480383 198 5393180
SGTC_3217 9129673 49.47 µM 0.924919850183077 0.160982032158811 no 583 0.177503800172402 204 17248312
SGTC_307 1501-1223 22.3 µM 0.919983452178635 0.162278730486832 no 584 0.178790703366322 183 2830329
SGTC_2403 6032726 181.2 µM 0.919299573347554 0.162458907293749 no 585 0.178969450467129 184 2881040
SGTC_3353 9151644 39.2805 µM 0.918961566881948 0.1625480075654 no 586 0.179057837563285 194 4909158
SGTC_1412 3909-8563 178 µM 0.918348824161373 0.162709610799667 no 587 0.179218136900128 223 23767530
SGTC_1340 1486-1359 257 µM 0.917611438153293 0.16290422564854 no 588 0.179411163733757 210 4309068
SGTC_2989 9073649 71.4286 µM 0.91756861965963 0.162915531181407 no 589 0.179422376420032 218 21367202
SGTC_410 α-linolenic acid 100 µM 0.916118668621421 0.16329866848321 no 590 0.179802328594077 213 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1821 st053465 65.6 µM 0.915519780532113 0.16345709029095 no 591 0.179959411509522 186 675086
SGTC_2519 cryptotanshinone 88.04 µM 0.912879870901775 0.164156605859025 no 592 0.180652862607915 208 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.912715016939588 0.164200352696515 no 593 0.18069622193701 223 6728940
SGTC_1017 4239-0030 168 µM 0.912125212102812 0.164356929474133 no 594 0.180851403829483 208 1149593
SGTC_669 0108-0021 26.2 µM 0.910781818736566 0.164713924249263 no 595 0.18120517197892 242 17201
SGTC_2489 cantharidin 73.42 µM 0.907797664007862 0.165508732658649 no 596 0.181992566404071 195 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_359 0081-0058 15.9 µM 0.904957532407926 0.166267481687738 no 597 0.182743942935578 206 3494159
SGTC_1662 st014054 52 µM 0.894686607112336 0.16903010604465 no 598 0.185477320010367 213 2838777
SGTC_2425 5628681 7.85 µM 0.8944795788465 0.169086092937326 no 599 0.18553267558362 209 5714958
SGTC_3183 9108214 49.47 µM 0.89350062421809 0.169350994039957 no 600 0.185794568997722 167 4974831
SGTC_3064 1327-0027 10 µM 0.89084505686381 0.170070920183172 no 601 0.186506149689402 181 16000455 YPR107C YTH1
SGTC_2029 5175081 200 µM 0.889235587329436 0.170508201720117 no 602 0.186938240371646 200 1380876
SGTC_3038 9091290 49.47 µM 0.888596667308519 0.170681991242616 no 603 0.187109941408422 199 25236843
SGTC_907 3448-6986 75.5 µM 0.888589978639716 0.170683811194345 no 604 0.187111739412656 214 590582
SGTC_2157 5649910 96.377 µM 0.888262899795633 0.170772822789202 no 605 0.187199675647884 202 2858091
SGTC_2966 9084041 48.03 µM 0.883156417990976 0.172166357505765 no 606 0.188575882569877 193 17741380
SGTC_1498 4478-3555 97.6 µM 0.882603277192955 0.172317741432168 no 607 0.188725328645276 200 3437919
SGTC_107 0358-0022 2.6945 µM 0.88216220834143 0.172438514273732 no 608 0.188844547724426 204 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_558 k064-0027 21.3 µM 0.881985513737956 0.172486911679993 no 609 0.188892320558665 214 5088526
SGTC_1006 4099-6547 255 µM 0.877114389784231 0.173824543653314 no 610 0.190212254757429 218 3146833
SGTC_291 SEC14.278 35.5 µM 0.876936093010343 0.173873629567458 no 611 0.19026067530501 203 1068044
SGTC_1761 st044296 37 µM 0.87623994003276 0.174065368044524 no 612 0.190449803982812 225 1826700
SGTC_2106 5357045 167.29 µM 0.876156754638725 0.174088288433483 no 613 0.190472411251428 203 668842
SGTC_2022 5136654 200 µM 0.875575969084996 0.174248367946012 no 614 0.190630297071142 228 1713771
SGTC_924 2046-0044 21.3 µM 0.875081123371556 0.174384833993702 no 615 0.190764883617097 205 3623589
SGTC_1570 verbenone 133 µM 0.874935784326323 0.174424927756241 no 616 0.19080442353832 216 29025 A natural terpanoid with antifungal properties.
SGTC_1478 0453-0656 35.7 µM 0.872497054702781 0.175098557969041 no 617 0.191468637118005 234 5258496
SGTC_1408 3909-7976 48.8 µM 0.869945933349368 0.17580499686567 no 618 0.192164975862331 231 24152374
SGTC_1556 plumbagin 1.48 µM 0.86710138692333 0.176594814599439 no 619 0.192943230380812 223 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1634 st006576 41 µM 0.86701823140507 0.176617937295884 no 620 0.192966010260555 217 3915356
SGTC_2707 st078556 66.6 µM 0.865462474276207 0.177050892907691 no 621 0.193392501946424 199 17250899
SGTC_1700 st030840 7.9285 µM 0.865184938473907 0.177128199473676 no 622 0.193468645380323 236 5499307
SGTC_2474 5321570 43.32 µM 0.864515712363021 0.177314697600129 no 623 0.193652326352486 224 2841384
SGTC_155 k072-0202 43.6 µM 0.861541195969734 0.178145127354058 no 624 0.194470021072688 231 5857737
SGTC_275 trichlorophene 5.69 µM 0.859940696095941 0.178592969989093 no 625 0.194910866906706 213 62616
SGTC_1824 st053723 68.6 µM 0.858685405903586 0.178944713713193 no 626 0.195257052159203 215 675225
SGTC_1900 st060200 72.8 µM 0.858151054628547 0.179094575997032 no 627 0.195404529416453 211 688945
SGTC_2999 9069765 71.4286 µM 0.857611985909019 0.179245841299828 no 628 0.195553377195925 203 2097066
SGTC_826 1683-5028 118 µM 0.857179126814745 0.179367361810765 no 629 0.195672948173823 213 722377
SGTC_1022 4477-0945 21.3 µM 0.856538417444367 0.179547329095967 no 630 0.195850016191305 211 4648966
SGTC_1285 0929-0069 65.5 µM 0.855457947570648 0.179851076594944 no 631 0.196148837660878 209 1206237
SGTC_398 bronopol 33.3 µM 0.853952387188373 0.180274865692004 no 632 0.196565685572389 230 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1959 st077091 55.8 µM 0.85359861792752 0.180374536447469 no 633 0.19666371228862 239 821356 YKL052C ASK1
SGTC_2384 9036245 200 µM 0.853177124034292 0.180493333030795 no 634 0.196780543624933 191 6462766
SGTC_3142 9086498 49.47 µM 0.852904538789116 0.180570186357749 no 635 0.196856122251621 231 25236367
SGTC_1698 5-fluorocytosine 1.055 µM 0.850873861096056 0.18114336618714 no 636 0.197419713172337 234 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1404 3909-7820 48.3 µM 0.850211482201132 0.181330575737995 no 637 0.197603759551152 212 23741373
SGTC_3336 9143619 71.43 µM 0.848457349632317 0.181826934909999 no 638 0.198091657716724 217 45595730
SGTC_1491 4138-0063 26.5 µM 0.848192579105889 0.181901929614474 no 639 0.198165364685907 220 23883227
SGTC_729 4092-0585 94.1 µM 0.848002771596177 0.181955703385505 no 640 0.198218213595751 220 2169061
SGTC_3059 1327-0034 3 µM 0.847414575434854 0.182122406523395 no 641 0.198382041574148 220 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2765 myclobutanil 7.74 µM 0.847390968688499 0.182129099002435 no 642 0.198388618373928 240 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_378 3970-0959 8.33 µM 0.845692717077966 0.182610954202264 no 643 0.198862093520879 229 6615653
SGTC_246 cycloheximide 667 µM 0.845468636632491 0.182674593301616 no 644 0.19892461831879 226 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_443 clozapine 122 µM 0.843061318602744 0.183359147582334 no 645 0.19959707539168 221 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1354 1498-1681 81 µM 0.842594489333818 0.183492081882279 no 646 0.199727637054341 209 5754243
SGTC_584 0986-0246 15.4 µM 0.842145154980818 0.183620091052544 no 647 0.199853354296812 254 53315 YDR232W HEM1
SGTC_1228 0124-0032 52.5 µM 0.84171633252759 0.183742308547259 no 648 0.199973376979492 216 X1228
SGTC_1776 st049249 45.9 µM 0.841399923368747 0.183832519925715 no 649 0.200061964199786 234 1822314
SGTC_1860 st056228 74.6 µM 0.841264228422514 0.183871216346972 no 650 0.200099962862203 243 688679
SGTC_254 nsc-64875 3.808 µM 0.840381779335274 0.184122990015026 no 651 0.200347180949354 199 56993
SGTC_3017 9080681 49.47 µM 0.840258595024036 0.184158153088136 no 652 0.200381705619916 228 16451914
SGTC_101 0490-5701 117.494 µM 0.839711326296395 0.184314421970511 no 653 0.200535130958212 199 4661669
SGTC_1872 amphotericin b 148 nM 0.837815910119257 0.184856282702111 no 654 0.20106705086707 218 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2400 5203494 178.7 µM 0.836851047950214 0.185132496947354 no 655 0.201338149588097 246 6777674
SGTC_2369 9071472 200 µM 0.836006446897124 0.185374493953795 no 656 0.201575638116882 222 17296037
SGTC_459 nigericin 15.3 µM 0.835751087203406 0.185447698837521 no 657 0.201647474273561 234 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1295 1013-0063 9.78 µM 0.834814611190174 0.185716315329933 no 658 0.201911048927634 216 6826038
SGTC_221 trifluoperazine 10.304 µM 0.834614004427675 0.185773888259456 no 659 0.201967537257443 255 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_975 1335-0046 28.5 µM 0.828329666489915 0.187583057501704 no 660 0.203741913145528 242 16486740
SGTC_3093 9117344 49.47 µM 0.827498242704094 0.187823225061314 no 661 0.203977358850655 217 24824913
SGTC_735 3076-0345 636 µM 0.827039221675598 0.187955900571587 no 662 0.204107415576654 233 2888990
SGTC_1956 st077085 54 µM 0.827028173680841 0.187959094598653 no 663 0.204110546468942 252 24208685
SGTC_1307 1187-1599 12.2 µM 0.822348940985985 0.189314894146048 no 664 0.205439165006774 244 1538471
SGTC_1522 st012842 45.6 µM 0.821446499241186 0.189577065898856 no 665 0.205695993280015 235 3491067 YOR116C RPO31
SGTC_2570 licareol 100 µM 0.819021554009115 0.190282651667026 no 666 0.206387058134819 225 443158
SGTC_2936 9038235 15.59 µM 0.81621512993076 0.191101247129667 no 667 0.207188552437247 233 4749415
SGTC_336 4111-0029 111 µM 0.814948795743368 0.191471325435861 no 668 0.207550810201479 230 3131175
SGTC_616 4092-0450 108 µM 0.812623580386057 0.192151997606658 no 669 0.208216953860355 258 787165
SGTC_2282 7944268 200 µM 0.810676317442766 0.192723167320087 no 670 0.208775788513988 233 2970414
SGTC_360 0957-0399 1.01 µM 0.807419419226815 0.193680793884676 no 671 0.209712441287892 239 6752301 YPR165W RHO1
SGTC_2137 5261020 140 µM 0.807212501485094 0.193741731821687 no 672 0.209772032211114 211 763655
SGTC_1231 0242-0792 125 µM 0.806632299463245 0.193912665504938 no 673 0.209939179591104 231 3707635
SGTC_3351 9150312 21.596 µM 0.80643248312386 0.193971554793071 no 674 0.209996761754626 246 4904905
SGTC_115 0527-0192 112.043 µM 0.803982740887392 0.194694421169245 no 675 0.21070347134486 258 4233931
SGTC_2757 clomiphene 4.22 µM 0.803702310651997 0.194777274532535 no 676 0.210784459672524 259 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2241 6772625 37.8075 µM 0.802862118721073 0.195025638347976 no 677 0.211027216602142 231 2285411
SGTC_1641 st009299 47.1 µM 0.801926759112674 0.195302360441149 no 678 0.21129766304871 233 4046054
SGTC_2262 9014885 67.46 µM 0.798717243842341 0.196253693854293 no 679 0.212227192840508 229 6457424
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.797351806054723 0.196659274142744 no 680 0.212623370310263 250 1273210
SGTC_973 1325-0077 65.9 µM 0.796401277018752 0.196941912292566 no 681 0.212899418113649 232 2835149
SGTC_985 1493-0307 8.71 µM 0.79611861371779 0.197026009144266 no 682 0.2129815480806 245 3278274
SGTC_2310 7668677 200 µM 0.795274426529111 0.197277297689407 no 683 0.213226943100281 249 2197143
SGTC_247 mechlorethamine 29.705 µM 0.794939815927065 0.197376954596019 no 684 0.213324255972225 217 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_491 tetrandrine 80.3 µM 0.794629862211136 0.197469295113119 no 685 0.213414421121253 234 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1925 st057770 10.1 µM 0.793620359679193 0.197770224230032 no 686 0.213708238099658 227 5989122
SGTC_1429 4049-0205 9.46 µM 0.793237314005983 0.197884481266256 no 687 0.213819785658676 223 22774478
SGTC_918 glabranin 770.725 nM 0.7912312107896 0.19848352413424 no 688 0.214404540837631 214 124049 Also referred to as licorice root.
SGTC_340 k038-0059 454 µM 0.789675446028419 0.198948843694487 no 689 0.214858667298903 246 23733424
SGTC_1578 josamycin 24.2 µM 0.788727170246974 0.199232789289077 no 690 0.215135742088676 245 5282165 A P450 substrate.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.784780113723856 0.200417290326715 no 691 0.216291250800308 248 688803
SGTC_3067 9117431 49.47 µM 0.783862538145158 0.200693257072266 no 692 0.21656038669406 264 17150885
SGTC_3331 9141060 1.957 µM 0.783297342388355 0.200863356795985 no 693 0.216726261752277 229 4906567 YPR165W RHO1
SGTC_1684 st024538 14.6195 µM 0.779137943572604 0.202117816629737 no 694 0.217949230412944 235 6732859
SGTC_301 4119-0100 24.5 µM 0.776092740816022 0.203039204381176 no 695 0.218847114758167 257 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_210 3551-0445 56.827 µM 0.774976679959833 0.203377518247109 no 696 0.219176719793392 249 2865180 YOR207C RET1
SGTC_452 diindolylmethane 8 µM 0.774890086048585 0.203403781694111 no 697 0.219202305403718 232 3071 Inhibits expression of several cancer promoting factors.
SGTC_1000 4048-0884 8.67 µM 0.774887340773878 0.203404614353604 no 698 0.219203116568836 248 13040088
SGTC_1637 st007924 17.4 µM 0.774313759402924 0.203578629872871 no 699 0.219372634424862 227 683336
SGTC_367 0335-0881 7.1 µM 0.773171934579487 0.20392530565432 no 700 0.219710316697725 250 23828853
SGTC_617 3770-0098 35 µM 0.773157620046791 0.203929654000798 no 701 0.21971455195838 254 5962639
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.772847506119719 0.204023871324886 no 702 0.219806317303348 264 7104
SGTC_885 0865-0106 16.8 µM 0.772701408706206 0.204068266924734 no 703 0.219849556391328 249 2793380
SGTC_3270 9137563 49.47 µM 0.772421176299315 0.204153439128014 no 704 0.219932507822808 229 17015724
SGTC_781 4335-2806 94.4 µM 0.771397209744586 0.204464837529464 no 705 0.220235764234748 250 845254
SGTC_1114 scopoletin 1.73284 µM 0.770968534572158 0.204595285810623 no 706 0.220362791202806 241 5280460 A coumarin with genotoxic properties.
SGTC_1145 3546-0597 10.2 µM 0.770299792692471 0.204798886603118 no 707 0.220561039665829 256 875334
SGTC_1120 ficusin 1.78878 µM 0.770175833785575 0.204836639557236 no 708 0.220597798494647 242 6199 A DNA cross-linker.
SGTC_1695 st026914 34.495 µM 0.767468154065479 0.205662323213161 no 709 0.221401610218943 242 3289191
SGTC_2589 lobaric acid 100 µM 0.765393025659644 0.206296450857517 no 710 0.222018772361562 251 73157 A novel microtubule depolymerizer.
SGTC_2523 spermine 47.74 µM 0.765135224001811 0.206375311964029 no 711 0.222095513459845 216 1103 A DNA binding polyamine.
SGTC_2387 9077560 195.08 µM 0.763303216613688 0.206936234364386 no 712 0.222641292103136 238 5303272
SGTC_1058 3448-5425 97.3 µM 0.763216863215633 0.206962696218831 no 713 0.222667036749012 254 7279705
SGTC_2330 7979373 200 µM 0.762765340134534 0.207101092088264 no 714 0.222801677515819 239 1863007
SGTC_464 bw-b 70c 158 µM 0.762217880034862 0.207268966924759 no 715 0.222964988182203 262 5353454
SGTC_1054 3429-0080 167 µM 0.762188992636103 0.207277827279416 no 716 0.222973607361738 255 1162877
SGTC_455 paf C-16 10 µM 0.761775714927928 0.207404612507313 no 717 0.223096938472252 231 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1930 st074634 34.3 µM 0.761399856662836 0.207519958005019 no 718 0.223209136521255 248 684253 YOR116C RPO31
SGTC_1729 st035615 45.989 µM 0.761176622670086 0.207588483249508 no 719 0.223275789656781 258 17385451
SGTC_1723 st034307 2.5525 µM 0.76049093685451 0.207799049071738 no 720 0.223480592334188 269 867466
SGTC_722 3534-0461 190 µM 0.760274939858559 0.20786540525613 no 721 0.223545129086155 241 658262
SGTC_2630 antimycin a 100 µM 0.759351250968352 0.208149311778227 no 722 0.22382123341513 266 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_3187 9109394 49.47 µM 0.757781128910588 0.208632431807819 no 723 0.224291010704521 251 17098090
SGTC_3025 9087895 49.47 µM 0.756872668682585 0.208912262854843 no 724 0.22456307557861 259 17173641
SGTC_1427 4048-4900 550 nM 0.756215941696706 0.209114690674518 no 725 0.224759868143085 256 24132586
SGTC_1051 3253-3903 78 µM 0.755666579145657 0.209284113441174 no 726 0.224924563340107 266 5509239
SGTC_600 1495-0418 41.6 µM 0.755524327584767 0.209327996820916 no 727 0.224967220548299 264 5377768
SGTC_2158 5657123 3.6195 µM 0.754689968755097 0.209585498337087 no 728 0.225217513393453 265 2858827
SGTC_1912 st060209 90.8 µM 0.754030161604772 0.209789261218675 no 729 0.225415555467015 256 688787
SGTC_1855 st056195 39.6 µM 0.752132577679335 0.210375925377116 no 730 0.225985667200325 238 4028379
SGTC_3168 9103419 49.47 µM 0.751968397229314 0.210426729252211 no 731 0.226035032000661 248 16649256
SGTC_390 dec-rvkr-cmk 16.7 µM 0.75131845719598 0.21062791688215 no 732 0.226230511916238 240 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2220 6782180 200 µM 0.75105864795046 0.210708371876295 no 733 0.226308680438311 231 833803
SGTC_1954 st077032 68.9 µM 0.748945362213396 0.211363461385044 no 734 0.226945068869761 284 698907
SGTC_631 k072-0230 41.5 µM 0.748685459876976 0.211444109830712 no 735 0.227023404702866 257 5773147
SGTC_1334 1486-0610 236 µM 0.742049755926919 0.213509284291091 no 736 0.229028595014104 239 3742339
SGTC_1970 st070122 35.8 µM 0.741263825693251 0.213754658922444 no 737 0.229266745337403 274 102928
SGTC_184 1494-0393 24.714 µM 0.741144982825414 0.21379177704665 no 738 0.229302768843204 267 3090647
SGTC_2539 epi(13)torulosol 80 µM 0.739242109062137 0.214386611547566 no 739 0.229879997622197 260 6708597
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.738656258096312 0.214569940974314 no 740 0.23005787669356 238 4174840
SGTC_851 0394-0702 453 µM 0.737801175648399 0.214837684096031 no 741 0.230317639395215 268 762646
SGTC_2278 7948257 134.34 µM 0.736880184550132 0.215126281496657 no 742 0.230597607639178 258 1247028
SGTC_1032 k061-1018 98.7 µM 0.73636389221015 0.215288162811519 no 743 0.230754636341096 248 4005393
SGTC_321 4534-3890 65.3 µM 0.735039231421666 0.215703827899822 no 744 0.231157800868888 257 699746
SGTC_2187 6125751 200 µM 0.735037250534058 0.215704449830402 no 745 0.231158404052211 261 874498
SGTC_1469 k284-2957 126 µM 0.733804531506823 0.216091682781182 no 746 0.231533939179511 244 23884841
SGTC_138 0850-0259 40.9225 µM 0.733677152413844 0.216131719203259 no 747 0.23157276328306 255 6813004
SGTC_576 1073-0113 22.7 µM 0.733235125428535 0.216270685670717 no 748 0.231707517626437 286 5439563
SGTC_1185 1319-0113 81.3 µM 0.732956438185641 0.216358327223876 no 749 0.231792499409148 258 4672763
SGTC_2175 5807670 165.306 µM 0.731188666938861 0.216914734423376 no 750 0.232331960760798 227 241186
SGTC_1800 st050079 29.0735 µM 0.729510528490184 0.217443694108925 no 751 0.232844714934306 260 3645560
SGTC_2077 5212015 200 µM 0.727997261178547 0.217921323272569 no 752 0.23330763142733 254 780900
SGTC_3103 9120822 49.47 µM 0.726872346296784 0.218276769313395 no 753 0.233652079517087 276 17141819
SGTC_2827 7993847 71.43 µM 0.72624011586237 0.218476685454596 no 754 0.233845791691353 237 2985692
SGTC_3106 9121286 49.47 µM 0.725907585516567 0.218581876415433 no 755 0.233947712993488 240 15943471
SGTC_16 erodoxin 22.806 µM 0.725266823129102 0.218784654140716 no 756 0.234144177494973 273 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_93 0109-0045 59.227 µM 0.722389823002845 0.219696451947148 no 757 0.23502742105007 267 88733
SGTC_2055 5235184 200 µM 0.722099854327854 0.219788471604611 no 758 0.235116543882823 282 2836034
SGTC_2315 7733312 200 µM 0.721009810831776 0.220134587608842 no 759 0.235451739278994 260 726316
SGTC_2140 5586273 200 µM 0.719362669526575 0.220658188712851 no 760 0.235958745779042 255 854421
SGTC_3047 9092122 49.47 µM 0.719021600197869 0.220766698538655 no 761 0.236063805458832 268 17173831
SGTC_3100 9120536 49.47 µM 0.718801544550221 0.220836724567005 no 762 0.236131602937034 257 16421196
SGTC_423 5-fluorouracil 457 µM 0.718224722237954 0.221020341102749 no 763 0.236309368419386 261 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_838 0109-0203 71.4 µM 0.71794976715306 0.221107896718865 no 764 0.23639413018606 246 759422
SGTC_708 3448-5400 146 µM 0.71764682195405 0.221204388372529 no 765 0.23648753997972 277 3462195
SGTC_582 0987-0078 156 µM 0.717639161664086 0.221206828578327 no 766 0.236489902208502 273 1625765
SGTC_1530 rhein 70.4 µM 0.717602898049886 0.221218380658342 no 767 0.236501085114592 266 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2472 5377652 49.4 µM 0.717477931004384 0.221258192607837 no 768 0.23653962444966 272 1610903
SGTC_664 1222-0054 14.9 µM 0.716448140347849 0.221586418879314 no 769 0.236857339293353 266 6813991
SGTC_2452 5863136 48.41 µM 0.716239693914285 0.221652891081843 no 770 0.236921678504239 261 2184096
SGTC_175 3793-3120 23.7 µM 0.716082630089721 0.221702985233615 no 771 0.236970164272159 285 5322297
SGTC_500 h-89 112 µM 0.715156402285244 0.221998529119206 no 772 0.237256202657681 269 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_665 3914-0008 307 µM 0.714603893105999 0.222174932665295 no 773 0.237426919227526 265 1069549
SGTC_196 k015-0023 18.111 µM 0.713630290320906 0.222485976372505 no 774 0.237727911093001 242 5211998
SGTC_1393 3470-5649 58.2 µM 0.713570302746736 0.222505149141496 no 775 0.237746463252897 246 4108395
SGTC_1506 4226-2149 212 µM 0.712042896741477 0.222993644248583 no 776 0.238219106537497 266 991114
SGTC_2690 usnic acid 100 µM 0.711208379787073 0.223260797349929 no 777 0.238477558278434 275 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2164 5685496 200 µM 0.710379204974802 0.223526420606925 no 778 0.238734507516759 271 759046
SGTC_3153 9100258 49.47 µM 0.709360148538872 0.223853117857936 no 779 0.239050505673879 267 25236848
SGTC_358 0075-0058 9.45 µM 0.705914103321174 0.224959886783149 no 780 0.240120778216298 308 1069125
SGTC_1345 1488-0192 31.4 µM 0.704529483511026 0.225405458105073 no 781 0.240551547832198 261 658348
SGTC_3240 9133527 49.47 µM 0.700578322154309 0.226679687164423 no 782 0.241783105413145 281 17617455
SGTC_1607 st000305 50.6 µM 0.700348826917717 0.226753822895789 no 783 0.241854742945372 279 5457690
SGTC_2326 6164455 177.58 µM 0.700318573663749 0.226763596873431 no 784 0.241864187435997 269 2888790
SGTC_1510 1123-0200 71.5 µM 0.699602617590052 0.226994971562355 no 785 0.242087753700074 281 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2878 9043973 25.97 µM 0.699561126681255 0.227008384210725 no 786 0.242100713190964 281 6465167
SGTC_2647 atorvastatin 60.16 µM 0.698961128589965 0.227202393842808 no 787 0.24228816182777 247 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1911 st060208 74.3 µM 0.698526158375557 0.227343100053658 no 788 0.24242410238068 283 688783
SGTC_2377 9073351 62.6 µM 0.697396141630523 0.227708872540194 no 789 0.2427774577584 281 7337946 YHR072W ERG7
SGTC_2492 derrusnin 100 µM 0.697373050299634 0.227716350371389 no 790 0.242784681305283 282 1715307 Part of coumarin class of compounds.
SGTC_1371 2421-0008 32.7 µM 0.69730885974982 0.227737138383424 no 791 0.242804762328763 266 2827552
SGTC_1508 1080-0625 72.9 µM 0.696851965271936 0.22788513382117 no 792 0.242947720685185 269 767111
SGTC_3024 9090631 49.47 µM 0.696348942310044 0.228048133578546 no 793 0.243105164896902 258 25236383
SGTC_84 0443-0269 128.823 µM 0.69586836465713 0.228203921378453 no 794 0.243255635337517 256 6150058
SGTC_2903 5923464 63.88 µM 0.695739753782119 0.228245623028896 no 795 0.243295912362024 271 2876576
SGTC_987 1497-1013 404 µM 0.693352635428022 0.229020415451632 no 796 0.244044139313912 270 1676435
SGTC_964 1287-0107 19.4 µM 0.692667792302145 0.229242968622958 no 797 0.244259027897319 259 51516812 YPR165W RHO1
SGTC_3137 9097352 49.47 µM 0.692600899254902 0.229264713326293 no 798 0.244280022918696 299 44120435
SGTC_1871 st057448 67.3 µM 0.691372967609675 0.22966407843551 no 799 0.244665593751842 288 691747
SGTC_2421 5690543 90.72 µM 0.690911840627444 0.229814153184348 no 800 0.244810472330837 282 3397993
SGTC_438 sphingosine 6.67 µM 0.690543265178382 0.229934146314584 no 801 0.244926305924615 251 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_263 alizarin 107.927 µM 0.686620941552026 0.231213265023956 no 802 0.246160814175278 289 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1987 st072290 61.9 µM 0.685911611361639 0.231445009611877 no 803 0.246384423822543 276 54697379
SGTC_1948 st076329 66.6 µM 0.684885145423685 0.231780594514201 no 804 0.246708200181772 267 24208413
SGTC_1272 0839-0021 27 µM 0.684410915287292 0.231935727180857 no 805 0.246857862676343 283 5027250
SGTC_2810 7959871 45.46 µM 0.682989318761877 0.232401113633115 no 806 0.247306795978711 271 2974535
SGTC_1035 k081-0041 55.2 µM 0.682963739160917 0.232409492352588 no 807 0.24731487788841 271 731709
SGTC_3303 9125618 40.5795 µM 0.682768571646071 0.232473425927791 no 808 0.247376545978158 261 22695467
SGTC_1081 sertraline 6 µM 0.682663920300447 0.232507711965638 no 809 0.247409616590304 274 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1594 piperine 70.1 µM 0.677974381609146 0.234046988876694 no 810 0.248893968301111 267 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2515 chrysin 20.77 µM 0.67747160557157 0.234212352571758 no 811 0.249053389866894 264 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_3165 9101544 49.47 µM 0.674294767184331 0.235258713042948 no 812 0.250061965107365 275 5002184
SGTC_2117 5521686 200 µM 0.674060002090741 0.235336140288368 no 813 0.250136583669991 270 803312
SGTC_2881 9058953 51.95 µM 0.673181849481352 0.235625886123408 no 814 0.250415803464815 241 17122249
SGTC_407 eburnamonine 100 µM 0.672726122220472 0.235776330533784 no 815 0.250560772830214 267 3195
SGTC_2355 9061122 103.12 µM 0.670537224692277 0.236499665680515 no 816 0.251257692455645 292 5302957
SGTC_959 1222-0044 107 µM 0.6666047067585 0.237802253752944 no 817 0.252512330924792 276 6083612
SGTC_2985 9022375 71.43 µM 0.666098380147815 0.237970252371746 no 818 0.252674109925036 288 4939335
SGTC_1623 st003709 20.3 µM 0.665534681128622 0.238157363609442 no 819 0.252854284472351 272 16192618
SGTC_2213 7173844 200 µM 0.665407735924086 0.238199512240415 no 820 0.252894869167742 282 892728
SGTC_396 dithiazanine 1.25 µM 0.665209817739835 0.238265233631175 no 821 0.252958150939139 266 10578 An antihelmenthic.
SGTC_1047 2043-3044 82 µM 0.662452731205017 0.239181793438307 no 822 0.253840559444686 319 669592
SGTC_561 1550-0330 72.9 µM 0.661242118055307 0.239584854944085 no 823 0.254228527370693 284 6812934
SGTC_992 3909-8734 162 µM 0.661240881036725 0.239585266986553 no 824 0.25422892395978 284 4288319
SGTC_2321 7390090 138.78 µM 0.660062204253851 0.23997805193208 no 825 0.254606955987551 291 649046
SGTC_2957 9076800 11.52 µM 0.658781448429584 0.240405251708615 no 826 0.255018060933972 291 16459615
SGTC_2127 5253358 187.912 µM 0.658047401912691 0.240650281641929 no 827 0.255253836197364 278 20612
SGTC_1224 0823-0416 294 µM 0.65762148380488 0.240792518426865 no 828 0.255390693045854 286 3598164
SGTC_1445 4239-0156 97.7 µM 0.656813370246163 0.241062516357021 no 829 0.255650463057707 290 4008346
SGTC_2502 avocadyne acetate 18.59 µM 0.654366709461864 0.241880970216131 no 830 0.256437788435083 260 3952079
SGTC_2289 7946404 165.07 µM 0.651993512357752 0.242676287301988 no 831 0.257202678806133 281 1246120 YPR165W RHO1
SGTC_1239 0337-0584 35.4 µM 0.651758234273243 0.242755211874515 no 832 0.257278574393195 294 914301 YML130C ERO1
SGTC_3305 9127027 53.8275 µM 0.651638823483774 0.242795273811908 no 833 0.257317098166576 289 41905295
SGTC_1762 st045503 25.4615 µM 0.648252026541925 0.243933021897143 no 834 0.258410978466367 282 4645554
SGTC_2918 7977171 22.06 µM 0.647080442444055 0.244327268168756 no 835 0.258789941134704 288 2236483
SGTC_1312 1218-2183 165 µM 0.646179695625437 0.244630609155708 no 836 0.259081493736526 284 6744073
SGTC_384 k007-0144 5.16 µM 0.645723384517255 0.244784356627203 no 837 0.259229256730389 298 6824886
SGTC_9 0092-0002 10.449 µM 0.645061242188336 0.245007548441501 no 838 0.259443749572621 301 759368
SGTC_1750 st081859 2.357 µM 0.642891965005678 0.245739524407651 no 839 0.26014710173918 292 5291695
SGTC_2067 5224629 34.075 µM 0.642428846087737 0.245895945883681 no 840 0.260297387586047 286 2835000
SGTC_2675 theaflavin digallate 100 µM 0.641924068124973 0.246066498820886 no 841 0.260461243065163 286 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2412 st077135 33.4 µM 0.641847169905588 0.246092486540492 no 842 0.260486209582334 314 13258915
SGTC_468 gf-109203x 121 µM 0.639541541671518 0.246872355940417 no 843 0.261235349055351 265 2396 A protein kinase C inhibitor.
SGTC_2183 6420625 130.508 µM 0.639358399019551 0.246934359860249 no 844 0.261294902771744 295 2897619
SGTC_3287 9117173 37.0625 µM 0.639281158636315 0.246960512501559 no 845 0.261320021632689 262 2789709
SGTC_2859 9028643 45.46 µM 0.638618730139776 0.247184863472277 no 846 0.261535496776844 270 17151580
SGTC_2638 epoxomicin 18 µM 0.638531837661231 0.247214300260099 no 847 0.261563767980432 287 9915668 A protesome inhibitor.
SGTC_1633 st005664 67.9 µM 0.636952082313965 0.247749804721889 no 848 0.262078028133541 301 2063822
SGTC_1317 1273-0028 910 nM 0.636530312259722 0.247892880751799 no 849 0.262215415174146 290 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2739 tacrine 100.86 µM 0.635813229888183 0.248136236054936 no 850 0.262449081680077 281 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_3000 9075062 71.4286 µM 0.634884234975117 0.248451697216588 no 851 0.26275195986737 272 17057871
SGTC_1783 st039459 87.517 µM 0.634876124893761 0.248454452118261 no 852 0.262754604766544 328 729761
SGTC_3073 9114972 49.47 µM 0.633769696817764 0.248830445608574 no 853 0.263115566089769 276 41905075
SGTC_1467 k284-1082 293 µM 0.633680747196042 0.248860686189498 no 854 0.263144596032332 302 3334705
SGTC_470 aa-861 153 µM 0.633057854177402 0.249072508583083 no 855 0.263347931650626 280 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2929 9013348 24.6 µM 0.632096609579033 0.249399579701196 no 856 0.263661875255661 299 2995952
SGTC_1519 esterone 74 µM 0.630614151961618 0.249904444869836 no 857 0.264146421631243 300 698 A steroid.
SGTC_1966 st070145 16.1 µM 0.629435719996252 0.250306157842929 no 858 0.264531919518622 303 3748532
SGTC_2738 aclarubicin 5.55 µM 0.625750960096053 0.251564452806688 no 859 0.265739151102672 252 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_3284 9108171 64.8615 µM 0.625679652297938 0.251588836360254 no 860 0.26576254107357 284 8687505
SGTC_1399 3562-5772 25 µM 0.624858209110325 0.251869817164197 no 861 0.266032061346032 299 23847490
SGTC_502 l-744,832 89.3 µM 0.621894135651454 0.252885076366002 no 862 0.267005740741444 318 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_3314 9135860 59.4275 µM 0.620084341267112 0.253506027513324 no 863 0.267601130402545 298 25252478
SGTC_2529 gangaleoidin 93.61 µM 0.619974338275056 0.253543796000139 no 864 0.26763734096444 310 4565183
SGTC_1270 0831-1170 17.3 µM 0.6189198553809 0.253905992667233 no 865 0.267984578769843 295 6764716
SGTC_2894 9048625 32.47 µM 0.618899607071173 0.253912950268301 no 866 0.267991248691797 316 4092861
SGTC_1964 st076914 61 µM 0.618345088311326 0.2541035295177 no 867 0.268173943179674 320 24208661
SGTC_1844 rapamycin 4 nM 0.616565096324309 0.254715790973004 no 868 0.268760811302264 290 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_621 3584-0052 32.1 µM 0.616256530381396 0.254822006492997 no 869 0.268862611891553 316 2273927
SGTC_2887 9044784 58.44 µM 0.614018975148897 0.255592917741458 no 870 0.269601394157698 285 6465546
SGTC_556 4058-0063 51.5 µM 0.61341895634258 0.255799850854061 no 871 0.269799677488517 294 6615692
SGTC_2277 7947813 106.88 µM 0.613286341903061 0.255845598416055 no 872 0.269843511353746 310 1246798
SGTC_236 1509-0011 5.31 µM 0.61299108133031 0.255947468809116 no 873 0.269941118449055 323 3107280
SGTC_462 ag-879 158 µM 0.612865720393421 0.255990727065263 no 874 0.269982565549485 317 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1208 2323-2347 50.3 µM 0.612578305459936 0.256089919634953 no 875 0.27007760330746 296 5412760
SGTC_467 ro 31-8220 72.8 µM 0.61248775188336 0.256121175614992 no 876 0.270107549577969 307 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1891 st059073 26.2 µM 0.609596917404515 0.257120036821222 no 877 0.27106442706705 309 688754
SGTC_711 k292-0785 179 µM 0.608337472860187 0.2575558415165 no 878 0.271481836238727 297 4146315
SGTC_104 0074-0074 590.992 µM 0.607978098899824 0.25768026574614 no 879 0.27160099980261 292 3943124
SGTC_3340 9146634 11.102 µM 0.606540953844167 0.258178152970403 no 880 0.272077797921597 287 4907387
SGTC_3005 9076496 71.4286 µM 0.604769151692299 0.25879266517846 no 881 0.272666196654338 300 21368410
SGTC_46 0329-0187a 2.197 µM 0.604589029272772 0.258855179200216 no 882 0.272726048950283 313 46494817
SGTC_2199 6590217 200 µM 0.604536072222371 0.258873560176342 no 883 0.27274364711718 299 703109
SGTC_202 3594-0513 34.79 µM 0.603727478287461 0.259154300628815 no 884 0.273012421070743 298 708429
SGTC_1682 st012968 530 nM 0.603490894081663 0.259236471433526 no 885 0.273091085701431 292 24207270
SGTC_3334 9142812 21.919 µM 0.602811579429018 0.259472486905077 no 886 0.273317021339982 307 45283678
SGTC_2778 tioconazole 65.09 nM 0.602673572957908 0.259520448292915 no 887 0.273362932707092 307 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1132 3456-3614 2.5 µM 0.602062722273846 0.259732792191215 no 888 0.273566193594578 308 3125502
SGTC_2444 5485484 36.41 µM 0.601094221735944 0.260069646012703 no 889 0.273888615886239 332 6790631
SGTC_501 nsc-95397 161 µM 0.599793574481059 0.260522377761707 no 890 0.274321908071096 302 262093
SGTC_3126 9127922 49.47 µM 0.599718782772435 0.260548423733531 no 891 0.274346834153998 340 45595682
SGTC_2932 9016711 44.54 µM 0.59912334559205 0.260755830628468 no 892 0.274545317370303 315 7117328
SGTC_532 1548-0774 215 µM 0.597583778962004 0.261292496901895 no 893 0.275058845165795 333 5932993
SGTC_1105 epirubicin 18.1 µM 0.59544097798803 0.262040383565935 no 894 0.275774370462216 305 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_943 3253-1379 105 µM 0.595421496680385 0.262047188018796 no 895 0.275780879864983 322 668464
SGTC_2851 9015922 71.43 µM 0.593389557211818 0.262757403135657 no 896 0.276460237983812 313 2996893
SGTC_1955 wogonin 32.4 µM 0.593358634676842 0.262768218957981 no 897 0.276470582952281 275 5281703 A flavanone.
SGTC_2740 felodipine 17.08 µM 0.59012278557071 0.263901284177085 no 898 0.277554166900387 283 3333 L-type calcium channel blocker
SGTC_2097 5376186 200 µM 0.589932822003222 0.263967879153117 no 899 0.277617844150958 308 742755
SGTC_1781 st038725 66.3 µM 0.589654128655796 0.264065595368139 no 900 0.27771127722152 303 4270275 YIL048W NEO1
SGTC_1175 0741-0056 27.6 µM 0.58948615696442 0.264124498957188 no 901 0.277767597826345 322 765927
SGTC_521 r062-0005 13.8 µM 0.587641013210214 0.264771986323275 no 902 0.278386638077229 291 2832033
SGTC_968 1309-0633 340 µM 0.586510494137147 0.265169099988954 no 903 0.278766255750987 313 3761976
SGTC_1152 3909-8331 15.9 µM 0.586486040696354 0.265177693008362 no 904 0.278774469769684 329 16001939
SGTC_1475 4092-1048 11.7 µM 0.584259846765331 0.265960576837532 no 905 0.279522751265381 323 2881759
SGTC_1523 st012844 44.7 µM 0.584255895501792 0.265961967415503 no 906 0.279524080254042 302 4274103
SGTC_2134 5324836 1.464 µM 0.583660764868505 0.266171455263992 no 907 0.279724284629998 323 699272
SGTC_764 1951-2361 146 µM 0.582424327227789 0.266606952108565 no 908 0.280140449612044 314 5438930
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.5818708363593 0.266802018787911 no 909 0.280326842884404 313 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2456 5770359 74.46 µM 0.581710205072585 0.266858643540899 no 910 0.280380948228082 328 3118787
SGTC_2276 7947513 42.08 µM 0.579341335846059 0.26769440716202 no 911 0.281179439652 303 2105100
SGTC_370 0180-0345 38.7 µM 0.578307940132073 0.268059413555676 no 912 0.281528117325841 296 3989527
SGTC_1811 st050069 61.5 µM 0.576889462752836 0.268560842546554 no 913 0.282007064634297 313 3877702
SGTC_1719 st032227 49.2 µM 0.576769977759465 0.268603101777917 no 914 0.2820474265229 295 3125804
SGTC_2597 laccaic acid a 100 µM 0.576181878159256 0.268811148448545 no 915 0.282246126400008 323 5491415 A textile dye.
SGTC_2963 9082507 9 µM 0.575828100976502 0.268936339974453 no 916 0.282365688736186 318 16459611
SGTC_2941 9056145 11.23 µM 0.575470276285202 0.269062993566059 no 917 0.28248664374475 310 2119517
SGTC_602 3130-1533 38.1 µM 0.575393331942587 0.269090232257707 no 918 0.282512656393844 328 720941
SGTC_365 0121-0052 13.6 µM 0.575271559141543 0.269133343281122 no 919 0.282553826597272 273 3101739
SGTC_2746 daunorubicin 9.88 µM 0.575184029572375 0.269164333370372 no 920 0.282583421277658 285 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_786 4544-0069 423 µM 0.574609474203235 0.269367800744306 no 921 0.282777721556313 303 748821 YLR208W SEC13
SGTC_2990 9074105 71.4286 µM 0.573737603956067 0.269676703505978 no 922 0.283072688835682 315 6502001
SGTC_1049 3226-0134 66 µM 0.571176830088814 0.270585007874106 no 923 0.283939891266833 309 5702385
SGTC_3178 9107506 49.47 µM 0.569788597892374 0.271078050648049 no 924 0.284410544959912 309 8897194
SGTC_3147 9097027 49.47 µM 0.569443264214118 0.271200768473318 no 925 0.284527681638019 341 25236841
SGTC_956 1185-0240 191 µM 0.568702313887002 0.271464166120143 no 926 0.284779088632988 308 1416193
SGTC_3319 9138450 16.7555 µM 0.567853243299705 0.271766155635609 no 927 0.285067311479685 304 2029690
SGTC_2794 7785382 27.27 µM 0.567314790622187 0.271957754063604 no 928 0.285250164975858 328 2205081
SGTC_1230 0170-0365 3.77 µM 0.567199467790868 0.271998798294553 no 929 0.285289334796371 310 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_671 0560-0003 407 µM 0.566843209841686 0.272125612533888 no 930 0.285410355291042 311 3238678
SGTC_2930 9013230 14.89 µM 0.565556795673989 0.27258377144571 no 931 0.285847552385374 309 2995857
SGTC_1343 1487-0095 224 µM 0.563276374371829 0.27339688783765 no 932 0.286623351617286 336 4560101 YGL055W OLE1
SGTC_320 4092-0846 5.34 µM 0.563061628804144 0.273473520228723 no 933 0.286696459465561 316 1359356
SGTC_2688 kanamycin b 96.69 µM 0.562382952235598 0.273715777219963 no 934 0.286927565804113 303 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2049 5262831 67.185 µM 0.561831336661991 0.273912757326902 no 935 0.287115469695528 324 763417
SGTC_691 1548-0686 185 µM 0.561794148336569 0.273926039676618 no 936 0.287128139728127 318 46495133
SGTC_2669 eugenol 100 µM 0.561043623447603 0.27419416855648 no 937 0.287383899517625 302 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2743 auranofin 4.32 µM 0.560429196018409 0.274413772375734 no 938 0.287593360948194 274 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1313 1220-0047 237 µM 0.559176335311178 0.274861828795063 no 939 0.288020690985158 317 3528706
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.55851088964111 0.275099956451795 no 940 0.28824778528732 343 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_3245 9134821 49.47 µM 0.555565879018474 0.276155037542506 no 941 0.289253831251672 339 17014901
SGTC_1347 1493-0251 600 nM 0.554463401831359 0.276550521933008 no 942 0.289630872925259 304 3986378
SGTC_2342 7990637 118.86 µM 0.554218113062381 0.276638550504439 no 943 0.289714791819928 340 2033102 YER133W GLC7
SGTC_2986 9022445 71.43 µM 0.552442286432105 0.277276263655657 no 944 0.290322682778453 339 6459286
SGTC_1916 st067606 49.2 µM 0.551495492488531 0.27761655833103 no 945 0.290647027885536 316 19590279
SGTC_1113 artemisinin 1.17947 µM 0.547872495487228 0.278920609300011 no 946 0.291889727874232 324 2240 An anti-malaria and mitochondrial poison.
SGTC_329 k048-0121 21.3 µM 0.547203539515326 0.279161716885881 no 947 0.29211945237302 314 6832902
SGTC_1733 st037357 54.9 µM 0.54676938242342 0.279318251588283 no 948 0.292268590186115 326 1272339 YGL099W LSG1
SGTC_1241 0364-0022 50.8 µM 0.546339039335235 0.279473453232207 no 949 0.292416452788266 328 4563895
SGTC_1141 3253-0389 52.6 µM 0.544862939451468 0.280006121159715 no 950 0.292923893488886 339 5402031
SGTC_662 k832-1615 104 µM 0.543049077175878 0.280661347851141 no 951 0.293548006216652 333 5878478
SGTC_3259 9138485 49.47 µM 0.542852823660591 0.280732285516583 no 952 0.293615569917368 300 17646153
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.542755050963119 0.280767629606864 no 953 0.293649232562868 337 6710655
SGTC_890 0929-0006 47.2 µM 0.542101240185202 0.281004032546663 no 954 0.29387438221166 313 1378169
SGTC_217 ketoconazole 989 nM 0.541676434790054 0.281157683938703 no 955 0.294020713167281 301 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_257 daunorubicin 18.5 µM 0.541513729317403 0.281216544977813 no 956 0.294076768567968 325 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2176 5809774 33.9695 µM 0.539732348286831 0.281861374030721 no 957 0.294690814013241 314 2870539
SGTC_837 0091-0265 12.5 µM 0.538120424417881 0.282445475873488 no 958 0.295246956348011 332 759367
SGTC_1187 1391-0724 117 µM 0.535774128265029 0.283296726117608 no 959 0.296057332377088 327 6997986
SGTC_2807 7945238 51.95 µM 0.535066862958525 0.283553567319727 no 960 0.296301811458974 337 17148797
SGTC_899 1083-0020 478 µM 0.534790167453603 0.283654078789314 no 961 0.296397481466435 349 767123
SGTC_1668 st014914 51.6 µM 0.534632421028484 0.283711388857324 no 962 0.296452030075928 331 2839556
SGTC_3262 9137218 49.47 µM 0.533704475294085 0.284048628408863 no 963 0.296773006196898 291 17650664
SGTC_3310 9130229 44.1445 µM 0.532394778299622 0.284524932348006 no 964 0.297226300482124 342 7761258
SGTC_1168 k815-0004 80.5 µM 0.530073155374857 0.285370184575697 no 965 0.298030605279433 341 642433
SGTC_273 hydroxyurea 18.1 mM 0.529734557279004 0.285493560610167 no 966 0.298147992290262 336 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_421 streptovitacin 30 mM 0.52657346609731 0.286646600572913 no 967 0.299244911042774 333 91467 include heat shock
SGTC_2654 protoveratrine a 100 µM 0.525249295778978 0.287130260518333 no 968 0.299704950099171 349 5702278 A heart drug and vasodilator.
SGTC_2899 9053889 58.44 µM 0.524523531395739 0.287395513466442 no 969 0.299957228690613 328 6470052
SGTC_808 0711-0032 135 µM 0.524314774299319 0.287471831636807 no 970 0.300029811281601 340 4252555
SGTC_2504 purpurogallin 52.29 µM 0.523896280917193 0.287624854810873 no 971 0.300175340842833 338 5281571 An antioxidant.
SGTC_930 2810-3379 265 µM 0.522520022047672 0.288128358686348 no 972 0.300654154816156 343 1015764
SGTC_2697 mebhydrolin 72.4 µM 0.52178571183084 0.28839717588817 no 973 0.300909769513013 328 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_183 3914-0051 30.55 µM 0.521305394582662 0.288573074962783 no 974 0.301077021804026 321 1596232
SGTC_42 0133-0086 60.653 µM 0.521143181062174 0.288632491299134 no 975 0.301133515981652 356 162923 Model of phenazepam hydroxylation.
SGTC_3090 9117696 49.47 µM 0.519934735050922 0.289075307890525 no 976 0.301554532279 329 7923821
SGTC_3211 9128781 49.47 µM 0.519758406309886 0.289139947568679 no 977 0.30161598642707 351 17194361
SGTC_939 1165-0479 45.3 µM 0.51844808399992 0.289620506385469 no 978 0.30207283671927 354 1377347
SGTC_332 4112-0506 40.9 µM 0.518184935345349 0.289717060966686 no 979 0.302164622240244 343 2790355
SGTC_2965 9082772 38.63 µM 0.515322260795294 0.290768409056679 no 980 0.30316392290606 277 16459634
SGTC_2600 tangeritin 87.95 µM 0.514818420814881 0.290953634181461 no 981 0.30333995590114 342 68077 A bioactive flavone.
SGTC_207 4185-0010 4.486 µM 0.514613986397167 0.291028805491743 no 982 0.303411394784692 335 3761753
SGTC_3118 9124250 49.47 µM 0.513663255769838 0.291378511900186 no 983 0.303743722956048 338 1504786
SGTC_3004 9076122 71.4286 µM 0.512965354419649 0.291635345064386 no 984 0.303987777910869 365 44782551
SGTC_373 0844-0104 25.9 µM 0.510849141144337 0.292414772587251 no 985 0.304728348083866 333 5375804
SGTC_2389 9091542 195.52 µM 0.509759107307128 0.292816623064784 no 986 0.305110118834273 332 3626624 YOL127W RPL25
SGTC_3318 9139014 38.6185 µM 0.508517071746366 0.293274822555665 no 987 0.305545384911559 345 16643984
SGTC_51 1013-0126 23.419 µM 0.505459063297261 0.29440436685984 no 988 0.306618221971506 356 1627850
SGTC_3281 9140613 49.47 µM 0.504281420627446 0.294839890732208 no 989 0.307031815809661 299 16013766
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.502801490805287 0.29538762923851 no 990 0.307551922699606 325 688667
SGTC_547 1120-0019 610 nM 0.5018330360924 0.295746318329419 no 991 0.307892486282716 322 3676939
SGTC_817 1391-0715 46 µM 0.496382581842585 0.29776873944979 no 992 0.309812255901532 373 1353946
SGTC_533 1222-0222 6.71 µM 0.49572794065954 0.298012071443239 no 993 0.310043185597008 363 3982874
SGTC_1487 3970-0795 2.82 µM 0.49527878699133 0.298179075543492 no 994 0.310201671356423 331 3765103
SGTC_2019 4016004 108 µM 0.49467151223313 0.298404939903885 no 995 0.310416006867035 337 45595336
SGTC_1705 st027868 56.3335 µM 0.494387676914646 0.298510533776335 no 996 0.310516207640696 360 292948
SGTC_1233 0325-0408 14.2 µM 0.494095959626706 0.298619077649412 no 997 0.310619205594076 357 12874
SGTC_3136 9095672 49.47 µM 0.493902593404386 0.298691036373453 no 998 0.310687486470861 322 17217380
SGTC_2091 4-phenylthiadiazole 200 µM 0.493588452623234 0.298807956581962 no 999 0.310798428785244 335 270010
SGTC_977 1348-1378 135 µM 0.493185090682294 0.298958114547165 no 1000 0.310940905771087 337 X977
SGTC_167 3672-0051 66.205 µM 0.492431394250594 0.299238781965401 no 1001 0.311207205145441 358 3237971
SGTC_660 4031-1742 102 µM 0.49188905214044 0.299440817532116 no 1002 0.311398889036928 342 6738706
SGTC_1485 3909-9022 254 µM 0.490829640437939 0.299835652330812 no 1003 0.311773472057862 350 714516
SGTC_386 1509-0011 3.07 µM 0.490496220971426 0.29995996401255 no 1004 0.311891401649338 337 3107280
SGTC_2671 danthron 100 µM 0.490130518826403 0.300096338739954 no 1005 0.312020771718803 338 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_3148 9097893 49.47 µM 0.488899355091886 0.300555660490736 no 1006 0.31245647615233 294 17174100
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.488090534828516 0.300857587290856 no 1007 0.312742857558799 350 676296 Flavone; oxidizing agent.
SGTC_1833 st055984 71 µM 0.487783290156069 0.300972315365698 no 1008 0.312851674241611 340 676288
SGTC_643 k048-0106 28.4 µM 0.487280612636204 0.301160062441847 no 1009 0.313029742438919 347 6763920
SGTC_1071 trifluoperazine 6.31 µM 0.487077467937392 0.301235950751658 no 1010 0.313101716679406 376 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_766 1391-0721 126 µM 0.485225258446079 0.301928273404769 no 1011 0.313758283393039 366 1020919 YIL115C NUP159
SGTC_758 0868-0029 16 µM 0.484798437642559 0.302087912647422 no 1012 0.313909665549311 325 762687
SGTC_2298 7976326 193.81 µM 0.483636865540291 0.302522554886142 no 1013 0.31432180331815 327 2235818
SGTC_3138 9097216 49.47 µM 0.482834881354064 0.302822808405441 no 1014 0.314606490759464 350 25237486
SGTC_3315 9136395 68.55 µM 0.480679767137921 0.303630318282539 no 1015 0.315372056629762 387 16876844
SGTC_1053 3366-3204 134 µM 0.479108770186459 0.304219567594034 no 1016 0.31593062544809 344 3632071 YPR165W RHO1
SGTC_58 0957-0393 9 µM 0.478657093362111 0.304389076705838 no 1017 0.31609129727825 332 6997992
SGTC_43 0570-0105 72.5 µM 0.477839572271394 0.304695989825709 no 1018 0.316382196652052 346 1114046 YDL195W SEC31
SGTC_2784 7567673 72.73 µM 0.477124043355218 0.304964725987854 no 1019 0.316636897324988 353 3471247
SGTC_74 000s-0487 160.283 µM 0.476973949552251 0.305021111115583 no 1020 0.316690335963145 298 677548
SGTC_1020 4335-0961 93.3 µM 0.475468246327268 0.305587008493394 no 1021 0.317226630464961 369 669075
SGTC_2702 st077768 96.8 µM 0.475306062729254 0.305647990664728 no 1022 0.317284419208439 307 6484119
SGTC_895 0964-0006 13.7 µM 0.47504242858807 0.305747130456094 no 1023 0.317378365992583 359 6738897
SGTC_3084 9116877 49.47 µM 0.473942499026088 0.306160913257167 no 1024 0.317770455951621 347 27241325
SGTC_3158 9100007 49.47 µM 0.473498217859614 0.306328117690703 no 1025 0.317928886068203 334 19297233
SGTC_1389 3405-0187 19 µM 0.472123277822609 0.306845829429097 no 1026 0.318419399078737 335 799890
SGTC_2902 5787006 60.46 µM 0.472025011636485 0.306882844765224 no 1027 0.318454467970007 343 591003
SGTC_1564 D-Arginine 115 µM 0.471961175215631 0.30690689200202 no 1028 0.318477250559232 351 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1681 tripelennamine 100 µM 0.47194306469358 0.306913714403158 no 1029 0.318483714150992 316 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2598 perillyl alcohol 100 µM 0.471144981268493 0.307214426183556 no 1030 0.318768602600397 341 10819 An apoptosis inducer.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.470267485219882 0.307545209722061 no 1031 0.319081962295115 378 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.470117438657368 0.307601787404531 no 1032 0.319135557877855 339 165521
SGTC_829 1635-0120 117 µM 0.468749247792429 0.308117898713751 no 1033 0.319624440382461 354 285054
SGTC_3062 9077494 49.47 µM 0.468638680952824 0.308159623520441 no 1034 0.319663961876298 315 16459633
SGTC_2430 5571206 200 µM 0.468461501865103 0.308226491080297 no 1035 0.319727297812956 350 1731771
SGTC_3332 9141069 11.198 µM 0.468203192904773 0.308323988535924 no 1036 0.319819644539512 342 17332883
SGTC_490 phenamil 164 µM 0.466934400772563 0.308803084160467 no 1037 0.320273406059829 355 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_331 k048-0133 24.5 µM 0.466675549084813 0.308900866509381 no 1038 0.320366012925833 347 6813582
SGTC_1718 roemerine 11.9335 µM 0.465957230804416 0.309172285292571 no 1039 0.320623057297012 330 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2323 6148992 148.28 µM 0.464321216004515 0.309790847239504 no 1040 0.32120881293017 335 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3347 9188721 44.724 µM 0.464148880992999 0.309856036907448 no 1041 0.321270541366142 392 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2331 7980721 200 µM 0.463398185961868 0.310140074241581 no 1042 0.321539489349037 355 2981221
SGTC_415 dibenzyl ketone 100 µM 0.463368512374507 0.310151304041708 no 1043 0.321550122289127 387 7593
SGTC_1112 tnp00069 1.16933 µM 0.46139648797658 0.310898001897921 no 1044 0.322257085379409 366 145826
SGTC_357 1325-0123 420 µM 0.460364454642559 0.311289087374153 no 1045 0.322627321984083 375 1098503
SGTC_1785 bathophenanthroline 24 µM 0.457275737171388 0.312460818144669 no 1046 0.32373643339014 344 72812 An iron chelator.
SGTC_392 N-ethylmaleimide 8.33 µM 0.456505965145987 0.312753133605509 no 1047 0.324013091151134 331 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1361 1608-0041 5.61 µM 0.453163865866247 0.314023636182652 no 1048 0.32521537485396 340 X1361
SGTC_2552 juarezic acid 87.02 µM 0.453031469856044 0.314074012219512 no 1049 0.325263040466487 335 1549512
SGTC_1470 k295-0292 231 µM 0.452636998374234 0.314224127232952 no 1050 0.325405076230917 365 5045612
SGTC_1309 pyrazolanthrone 13.4 µM 0.452426577125392 0.314304215019382 no 1051 0.325480852140319 384 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1457 k015-0032 57.3 µM 0.452396371098275 0.314315712360404 no 1052 0.32549173038478 352 4302660
SGTC_1149 3909-7961 23.3 µM 0.451397919926435 0.314695854857476 no 1053 0.325851391114203 350 735261
SGTC_2467 5474540 200 µM 0.450622601920218 0.314991178926363 no 1054 0.326130786964609 331 5413519
SGTC_2083 5306046 65.942 µM 0.450256335899906 0.315130733385637 no 1055 0.326262809615511 336 539837
SGTC_559 1550-0661 158 µM 0.449699979770271 0.315342766347774 no 1056 0.326463392970383 369 5830875
SGTC_2838 9002687 71.43 µM 0.449579579031722 0.315388660298981 no 1057 0.326506807717021 366 6457060
SGTC_199 4063-0024 41.6 µM 0.448882893627963 0.315654276421666 no 1058 0.326758068418165 362 306215
SGTC_91 0417-1751 58.384 µM 0.448856539034831 0.31566432616295 no 1059 0.326767574787477 350 6795624
SGTC_299 1273-0059 1.44 µM 0.448159376935245 0.315930222988207 no 1060 0.3270190890525 350 2848077
SGTC_166 k072-0058 166.424 µM 0.447860717196624 0.316044160624977 no 1061 0.327126860190938 366 5846229
SGTC_2925 9010536 32.5 µM 0.447054670032862 0.316351751973675 no 1062 0.327417793629628 318 2994177
SGTC_105 0111-0055 734.78 µM 0.44691995393238 0.316403172666591 no 1063 0.327466428085214 360 5179370
SGTC_2572 astragaloside iv 100 µM 0.446348770774308 0.316621230822776 no 1064 0.327672665964114 341 45006101 An anti-inflammatory agent.
SGTC_2742 clothiapine 36.27 µM 0.445515274996834 0.316939545317121 no 1065 0.327973711758878 366 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1554 st069299 38.7 µM 0.444653420667574 0.317268832570675 no 1066 0.328285117802911 318 24207999
SGTC_1482 3346-2049 8.48 µM 0.444505999913175 0.317325171873468 no 1067 0.328338395972963 341 3826804
SGTC_2052 5265182 7.135 µM 0.443898339048236 0.317557444291571 no 1068 0.328558042730679 369 1239884
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.443786150714438 0.317600335042868 no 1069 0.328598601114345 377 368090
SGTC_1861 st057647 17.4 µM 0.442910941954179 0.31793502034965 no 1070 0.32891507632509 400 688668
SGTC_2133 5320837 200 µM 0.440934959768025 0.318691195086499 no 1071 0.329630041797931 369 2841355
SGTC_804 1595-0054 20.9 µM 0.440470072132528 0.318869209582644 no 1072 0.329798341753643 369 761523 Stimulates phospholipase C.
SGTC_127 0180-0333 59.125 µM 0.440130198791606 0.318999380130029 no 1073 0.329921405487151 328 771601
SGTC_2235 salicylic acid 500 µM 0.439569188623395 0.319214294304816 no 1074 0.330124580270478 344 338 A COX inhibitor and kinase inhibitor.
SGTC_1907 st060210 83.7 µM 0.437879082221329 0.319862114558337 no 1075 0.330736969883734 375 688793
SGTC_344 k064-0035 6.43 µM 0.437275711586507 0.32009352068626 no 1076 0.330955703827965 373 5088750
SGTC_47 0149-0135 24.25 µM 0.436673897395917 0.320324399619289 no 1077 0.331173931025119 337 5239155
SGTC_2612 dictamnine 15.46 µM 0.436267750786216 0.320480252310559 no 1078 0.331321238530197 346 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_3308 9128332 17.569 µM 0.436118525850786 0.320537523104378 no 1079 0.33137536828551 367 17332805 YDL196W YDL196W
SGTC_1703 st026983 48.3 µM 0.43547328253568 0.320785209151696 no 1080 0.331609463959751 362 1104023
SGTC_3066 9117245 49.47 µM 0.435348676010001 0.320833050378401 no 1081 0.331654679058937 355 17176980
SGTC_1350 1495-0454 146 µM 0.434373178955363 0.321207683901868 no 1082 0.332008735579232 375 1069057
SGTC_3088 9117578 49.47 µM 0.431671687788887 0.322246123735873 no 1083 0.332990023770372 357 678341
SGTC_2399 5884133 200 µM 0.431319462545252 0.322381619895272 no 1084 0.333118050378016 354 722445
SGTC_1620 st003704 16.5 µM 0.430836013040251 0.322567634629989 no 1085 0.333293805965761 358 2834414
SGTC_653 0203-0016 55.2 µM 0.430213993591291 0.322807031651721 no 1086 0.333519991797357 381 295302
SGTC_3282 9108498 15.4605 µM 0.427751763166583 0.32375539189094 no 1087 0.334415929605989 350 16459645
SGTC_2448 5185112 27.17 µM 0.426850576018654 0.324102782592803 no 1088 0.334744083025605 346 5718189
SGTC_3191 9110352 49.47 µM 0.425922058799123 0.324460868786682 no 1089 0.335082320324784 360 17122424
SGTC_2625 euphol 100 µM 0.422893506955764 0.325629968402457 no 1090 0.33618648018265 376 6708538 A triterpene alcohol.
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.42228661186661 0.325864452568197 no 1091 0.336407914545684 366 688669
SGTC_1896 st058441 89 µM 0.422038664386385 0.325960271092764 no 1092 0.336498398068756 347 688759
SGTC_1721 st082152 9.2685 µM 0.419894707146223 0.326789275466571 no 1093 0.337281187247768 363 5296051
SGTC_1265 0819-1001 68.8 µM 0.418255971223252 0.327423503145605 no 1094 0.337879988503447 406 3106768
SGTC_1106 tegaserod maleate 11.7 µM 0.418032607048732 0.327509988746412 no 1095 0.337961638571334 376 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1728 st035614 33.7865 µM 0.41615740905513 0.328236421652174 no 1096 0.33864741162835 381 15945546
SGTC_712 r015-0009 80.6 µM 0.416049378496248 0.328278291435479 no 1097 0.338686935490277 368 6813872 YLR060W FRS1
SGTC_2038 4100038 30.985 µM 0.41511447978466 0.328640723479081 no 1098 0.339029049984793 364 3596803
SGTC_1895 st058434 18.3 µM 0.414782672056956 0.328769394120594 no 1099 0.339150502816427 391 5393175
SGTC_2651 TUB2.036 5 µM 0.413411374182141 0.329301380441474 no 1100 0.339652621319557 367 15992207 YFL037W TUB2
SGTC_1169 aniline yellow 25.8 µM 0.412507700493875 0.329652144008756 no 1101 0.339983668856019 396 6051 A DNA damaging agent.
SGTC_305 1682-2595 20.8 µM 0.411602576216659 0.33000362089568 no 1102 0.34031537151996 373 226033
SGTC_2070 5230947 200 µM 0.411601291723524 0.330004119795411 no 1103 0.340315842338551 406 2835538
SGTC_3055 9094636 49.47 µM 0.411470747447459 0.330054825032836 no 1104 0.340363693384085 361 25236176
SGTC_3094 9117742 49.47 µM 0.410430942860005 0.330458811198116 no 1105 0.340744925801495 363 17149698
SGTC_2817 7995342 71.43 µM 0.409608264523765 0.33077857928564 no 1106 0.341046666696919 361 18879975
SGTC_1325 1431-0015 227 µM 0.409339362948116 0.330883125843839 no 1107 0.341145316129942 352 1103340
SGTC_603 3794-0023 45.9 µM 0.408913121810843 0.331048871657967 no 1108 0.341301709518637 368 3802260
SGTC_1650 st011916 45.8 µM 0.408664107260023 0.331145717430328 no 1109 0.341393088796245 395 242528
SGTC_181 1447-1644 8.07 µM 0.4080878460127 0.331369878028879 no 1110 0.341604591355387 377 534600
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.407696870151392 0.331521998641037 no 1111 0.341748117784879 337 3256 An antibiotic and ribosome inhibitor.
SGTC_1474 0330-0125 5.35 µM 0.404415784777512 0.332799694307334 no 1112 0.342953497334136 354 X1474
SGTC_2406 ethylparaben 405.7 µM 0.404396403633001 0.332807247357457 no 1113 0.34296062219347 343 8434 A possible steroid mimic.
SGTC_2112 5488546 200 µM 0.403615788923455 0.333111518067156 no 1114 0.343247636677388 382 600757
SGTC_3221 9128209 49.47 µM 0.402793415874385 0.333432184356221 no 1115 0.343550102591527 378 16460723
SGTC_2508 celastrol 40.54 µM 0.40258027354144 0.333515314400166 no 1116 0.343628511950125 338 122724 Celastrol is a natural product and antioxidant.
SGTC_3036 9090181 49.47 µM 0.401783259509251 0.333826239246284 no 1117 0.34392177167308 383 25236586
SGTC_1124 fisetin 1.16336 µM 0.400689570401354 0.334253086375313 no 1118 0.344324345241153 367 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.400568186541869 0.33430047353555 no 1119 0.344369036039807 401 442882
SGTC_2079 5212404 121 µM 0.400439636771082 0.334350661081977 no 1120 0.344416367534574 361 758462
SGTC_3033 9090887 49.47 µM 0.399885880445988 0.334566888784148 no 1121 0.344620286172983 362 19325384
SGTC_1831 st055328 12 µM 0.399792513580249 0.334603351569411 no 1122 0.344654672612979 366 1103068
SGTC_896 0964-0007 44.5 µM 0.39953885613656 0.334702420892371 no 1123 0.344748099562707 370 6756758
SGTC_1240 0356-0016 42.1 µM 0.399116578928224 0.334867372452643 no 1124 0.344903653438187 367 4305613
SGTC_197 4544-0043 41.561 µM 0.398613514041044 0.335063923199993 no 1125 0.345089001219156 353 896523
SGTC_2263 7948595 193.29 µM 0.397776246598544 0.335391149218541 no 1126 0.345397564024443 387 2971371
SGTC_1417 3966-0327 90.4 µM 0.397761153167486 0.335397049273195 no 1127 0.345403127433819 381 651118
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.397533345099918 0.335486104866288 no 1128 0.345487101100946 377 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1121 fusaric acid 630.51 nM 0.397306413457155 0.335574827034472 no 1129 0.345570759265272 337 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_759 3486-0358 89.3 µM 0.397068751915973 0.335667754038554 no 1130 0.345658381084297 392 875103
SGTC_2525 harmine 47.85 µM 0.396028090993063 0.336074776628535 no 1131 0.346042152612383 409 5280953 A monoamine oxidase inhibitor
SGTC_2943 9068529 45.32 µM 0.39525301032781 0.336378050617895 no 1132 0.346328087131696 388 3270634
SGTC_1795 st049545 62.3 µM 0.393917126915871 0.336901005675615 no 1133 0.346821112583753 353 5291882
SGTC_503 tyrphostin 8 294 µM 0.392854463987786 0.337317229105922 no 1134 0.347213487761481 415 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_327 1273-0057 3.96 µM 0.392069358317728 0.337624866976458 no 1135 0.347503483604795 382 3108138
SGTC_3034 9090421 49.47 µM 0.391859350916547 0.337707175236557 no 1136 0.347581069543724 392 17173761
SGTC_1888 azatryptophan 97.5 µM 0.391411867166361 0.337882583558471 no 1137 0.34774641094902 352 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2459 5811157 9.22 µM 0.39138110739682 0.337894642317071 no 1138 0.347757777484044 379 2870684 YBR192W RIM2
SGTC_945 3381-0768 11.3 µM 0.390736655058547 0.338147325336951 no 1139 0.347995950840265 400 1126236 YIL048W NEO1
SGTC_1338 1486-1223 76 µM 0.388440510754036 0.339048211630694 no 1140 0.348845034953201 387 3444526
SGTC_1004 4084-0029 199 µM 0.38724797332345 0.339516464398502 no 1141 0.349286318860492 401 716894 YLR208W SEC13
SGTC_1269 0831-0796 3.05 µM 0.387107912081631 0.339571476069142 no 1142 0.349338160198132 385 927758
SGTC_2240 6690706 185.951 µM 0.38473871018769 0.340502541504545 no 1143 0.350215506065786 347 805876
SGTC_733 4069-0007 56.1 µM 0.38400777590952 0.340789985783394 no 1144 0.350486342101038 378 5717425 YNL287W SEC21
SGTC_1301 naphtanilide LB 4.81 µM 0.383541789017608 0.340973286194142 no 1145 0.350659045803227 374 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1837 st055472 66.5 µM 0.380822889086502 0.342043538944794 no 1146 0.351667336880434 364 676091
SGTC_609 0986-0026 86.3 µM 0.380565327510095 0.34214499006302 no 1147 0.351762906624527 389 2848610
SGTC_803 4488-1585 147 µM 0.380493833567758 0.3421731528853 no 1148 0.351789436535418 406 747204
SGTC_2340 7987427 183.45 µM 0.379417552945717 0.342597226280227 no 1149 0.352188908972364 366 2239331
SGTC_1374 2889-5571 141 µM 0.378148428358521 0.343097538552246 no 1150 0.352660166999659 360 2853281
SGTC_655 k060-0012 42 µM 0.377877832555817 0.343204248019613 no 1151 0.352760675339276 410 5994525
SGTC_1862 st057513 3.81 µM 0.377798899173689 0.343235377758497 no 1152 0.352789995776345 379 5393163
SGTC_477 mead ethanolamide 10 µM 0.37711035231984 0.343506971885128 no 1153 0.353045799084214 356 16061185
SGTC_579 4491-1009 110 µM 0.374552212928991 0.344516725094137 no 1154 0.353996759206169 414 1271041
SGTC_1463 k081-0032 34.1 µM 0.374442032100945 0.344560240823021 no 1155 0.354037738230184 375 977755
SGTC_492 tmb-8 126 µM 0.37416408892418 0.344670023142507 no 1156 0.354141119806366 403 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_3083 9117465 49.47 µM 0.374144086518988 0.344677924220521 no 1157 0.354148560159798 396 16420915
SGTC_1218 1348-1416 30.7 µM 0.373709790818218 0.344849490501036 no 1158 0.354310120132637 354 6787668
SGTC_618 k072-0232 33.2 µM 0.371935771750664 0.345550638646854 no 1159 0.354970335338869 407 5872756 YGL099W LSG1
SGTC_841 0251-0215 91.2 µM 0.371028387440818 0.345909470589342 no 1160 0.355308194134991 398 3888614
SGTC_1915 st067105 30.6 µM 0.370649076252579 0.34605951309839 no 1161 0.355449461983679 395 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2341 7987486 176.74 µM 0.370357321607458 0.346174937686682 no 1162 0.355558134437375 419 1258686
SGTC_31 0508-1974 57.237 µM 0.370215856180365 0.346230909682721 no 1163 0.355610831554094 370 6810525
SGTC_269 exalamide 29 µM 0.369603488533374 0.346473236860967 no 1164 0.355838975712527 369 3316 A derivative of salicylamide.
SGTC_3295 9122362 53.5725 µM 0.369569301993617 0.346486767070383 no 1165 0.355851713798576 389 4730473
SGTC_2927 9011802 47.9 µM 0.368606812101442 0.346867777724977 no 1166 0.356210408639237 372 43912568
SGTC_1678 st019265 80.2 µM 0.368549204172133 0.346890587281113 no 1167 0.356231881649554 391 5367020
SGTC_2103 5378138 10 µM 0.366198869638005 0.347821662150154 no 1168 0.35710834279849 388 244142
SGTC_147 4466-0538 29.23 µM 0.366104796737338 0.34785894787616 no 1169 0.357143439175453 360 6742687 YHR072W ERG7
SGTC_1219 1469-0211 33.1 µM 0.364679247243406 0.348424143278268 no 1170 0.357675425805061 433 6822282
SGTC_2845 9003024 42.97 µM 0.363132918846994 0.349037605262695 no 1171 0.358252797465755 361 2990173
SGTC_2485 5633444 17.78 µM 0.362701832561685 0.349208696966098 no 1172 0.358413815313964 363 5724239
SGTC_2268 7933382 153.85 µM 0.362523511939744 0.349279478719336 no 1173 0.358480428374833 352 935025 YOR257W CDC31
SGTC_1934 st074720 32.6 µM 0.361428764107038 0.349714137606467 no 1174 0.358889474279918 379 17250992
SGTC_902 1120-0002 2.07 µM 0.361005022489314 0.349882432992043 no 1175 0.359047846251336 374 3280475
SGTC_2016 5121758 140 µM 0.35896826974792 0.350691771225938 no 1176 0.359809413248368 395 2795203
SGTC_2715 st079500 56.4 µM 0.35871689208421 0.350791707486484 no 1177 0.359903445131795 391 28246688
SGTC_2684 capsaicin 100 µM 0.358697345814514 0.350799478621921 no 1178 0.359910757085685 409 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1766 st045414 44.774 µM 0.358566999283154 0.350851302921844 no 1179 0.359959518995837 391 253960
SGTC_2667 digitoxin 100 µM 0.357857404374567 0.351133478446406 no 1180 0.360225014448651 377 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_736 0958-0254 92.6 µM 0.351967446719123 0.353478818381789 no 1181 0.362431338039779 417 6812352
SGTC_1414 3917-0015 5.4 µM 0.351947258718655 0.353486866737602 no 1182 0.362438908189681 410 6618702
SGTC_1089 terbinafine 2.25 µM 0.349698744641082 0.35438369169821 no 1183 0.363282397947872 395 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2871 9038510 12.99 µM 0.349234053345992 0.35456913579541 no 1184 0.36345680141306 417 4945164
SGTC_587 k089-0003 57 µM 0.348340809048518 0.354925699100623 no 1185 0.363792124737643 413 9659696
SGTC_94 0334-0113 514.748 µM 0.346901834121716 0.355500373167432 no 1186 0.364332534343846 401 6795178
SGTC_2640 pentamidine 10.38 µM 0.346692798870938 0.355583881587759 no 1187 0.364411060375056 393 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.346580917923269 0.355628580252714 no 1188 0.364453091829328 439 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1302 1159-0335 255 µM 0.346516457563185 0.355654334350806 no 1189 0.3644773090489 396 649284
SGTC_1438 4092-1045 4 µM 0.34623225606154 0.355767890336683 no 1190 0.364584087631153 390 1351342
SGTC_478 N-arachidonylglycine 10 µM 0.346030265596177 0.355848605737539 no 1191 0.364659984735711 386 5283389
SGTC_3250 9135583 49.47 µM 0.344631841208412 0.356407593269676 no 1192 0.365185582425257 372 7699353
SGTC_2490 carminic acid 95.39 µM 0.342476212541862 0.357269859787159 no 1193 0.365996271257099 394 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2843 9000894 45.46 µM 0.342144537100026 0.357402597132562 no 1194 0.366121060988527 354 2242070
SGTC_778 3456-2434 196 µM 0.34093456145819 0.357886978606195 no 1195 0.36657642279805 366 5539063
SGTC_1736 st036774 51 µM 0.340721235120634 0.357972401873867 no 1196 0.366656725456866 409 1272247
SGTC_3042 9091578 49.47 µM 0.339623721156016 0.358411996880417 no 1197 0.367069955992078 384 25236497
SGTC_2398 5228213 48.84 µM 0.339076959975661 0.35863106507691 no 1198 0.367275877329163 409 80771 YMR134W ERG29
SGTC_2366 9070441 60.58 µM 0.337304538327971 0.359341532324514 no 1199 0.367943669439138 382 6837235
SGTC_1381 2324-0066 62.1 µM 0.336884265571154 0.359510068230677 no 1200 0.36810207349177 408 10885928
SGTC_785 1270-0111 65.3 µM 0.336780466729936 0.359551697388971 no 1201 0.368141199532632 379 6741994
SGTC_1339 1486-1321 22.7 µM 0.335069483317698 0.360238137566048 no 1202 0.368786336175153 401 3469382
SGTC_1161 k007-0610 110 µM 0.334984518280859 0.360272236989943 no 1203 0.368818382412002 399 5843850
SGTC_295 k015-0027 31 µM 0.334921343745674 0.360297591848306 no 1204 0.368842210523269 397 3887424
SGTC_346 4513-0042 7.16 µM 0.334267395919288 0.360560087390904 no 1205 0.369088895549867 383 2827372
SGTC_1979 st071809 45.3 µM 0.333752954757131 0.360766630964551 no 1206 0.369282993173647 428 4976333
SGTC_2066 5222451 176 µM 0.332552885005509 0.361248606152602 no 1207 0.369735906574844 386 2281147
SGTC_1646 st011709 75.6 µM 0.331810318967627 0.361546947886737 no 1208 0.370016245955967 391 5757843
SGTC_3230 9131665 49.47 µM 0.331590465065839 0.361635295040551 no 1209 0.370099260193775 419 15943720
SGTC_119 0121-0043 24.815 µM 0.330259135732692 0.362170440276096 no 1210 0.370602083591218 405 1092378
SGTC_1857 st056007 79.3 µM 0.329499617008376 0.362475859568807 no 1211 0.370889041693237 387 619834
SGTC_2007 4011539 71.82 µM 0.329141138524193 0.362620042125713 no 1212 0.371024505452933 394 45595301
SGTC_717 1532-0246 73.2 µM 0.32903979733693 0.362660805794386 no 1213 0.371062803699515 363 9561992
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.328062604024009 0.363053953674092 no 1214 0.371432164144088 394 88881 An O-methylated flavonoid and antioxidant.
SGTC_2378 9074213 121.43 µM 0.326457826674445 0.363699906421617 no 1215 0.372038996185285 392 657714
SGTC_613 3914-0030 117 µM 0.326154300043328 0.363822125184953 no 1216 0.372153807839146 412 1145395
SGTC_2676 harmalol 100 µM 0.322187301464498 0.365420756179148 no 1217 0.373655401987353 397 5459187 A monoamine oxidase inhibitor
SGTC_2969 9091408 28.7 µM 0.321983210014547 0.365503065009282 no 1218 0.373732707107189 387 4286311
SGTC_1809 st050081 57.6 µM 0.321548707716654 0.365678317747372 no 1219 0.37389730344301 424 5036894
SGTC_798 1287-0182 476 µM 0.320044977447325 0.366285050557747 no 1220 0.374467117573843 428 1649755
SGTC_3011 9081274 71.4286 µM 0.31919092479629 0.366629797116556 no 1221 0.374790869145106 391 6625322
SGTC_1406 3909-7906 11.9 µM 0.317281020537635 0.367401137414777 no 1222 0.375515188690803 417 X1406
SGTC_1074 carmofur 3.8 µM 0.314800383371415 0.368403774664019 no 1223 0.376456610317285 400 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2198 6589944 200 µM 0.313604822595836 0.368887323525006 no 1224 0.376910598150146 386 5290268
SGTC_1116 jasmonic acid 1.58368 µM 0.313488403181825 0.368934420880991 no 1225 0.376954814960233 432 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1198 1612-1005 86.7 µM 0.312541372574379 0.369317614218336 no 1226 0.377314562924196 405 6998509
SGTC_2762 leflunomide 42.06 µM 0.309832507083896 0.370414407891931 no 1227 0.378344165052006 405 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2700 st077718 96.8 µM 0.309634083269475 0.370494789340213 no 1228 0.37841961725088 386 904970
SGTC_70 0141-0289 43.283 µM 0.308565139849357 0.370927915308681 no 1229 0.378826170990309 390 352408
SGTC_3078 9116413 49.47 µM 0.308373513782224 0.371005577722035 no 1230 0.378899066767308 394 17177322
SGTC_909 3448-9333 149 µM 0.30783996349221 0.371221843215893 no 1231 0.379102055384694 403 3344074
SGTC_1437 4092-1038 11.6 µM 0.307296726927093 0.371442076661068 no 1232 0.379308763391115 425 3977136
SGTC_435 c-PAF 6.7 µM 0.306878872397426 0.371611507642111 no 1233 0.379467785518528 422 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_3133 9127736 49.47 µM 0.306756931623937 0.371660956680582 no 1234 0.379514196138762 412 27243420
SGTC_2953 9074162 66.49 µM 0.303842754146115 0.372843333081605 no 1235 0.380623846260544 438 16451992
SGTC_3345 9148410 3.559 µM 0.302904760825233 0.373224163021758 no 1236 0.380981221543902 423 4903596
SGTC_2118 5526350 200 µM 0.301172254440559 0.373927894690805 no 1237 0.381641572958306 407 743594
SGTC_2275 7947463 200 µM 0.300195103982318 0.374324991793842 no 1238 0.382014169707534 413 1225414
SGTC_2648 atorvastatin 78.68 µM 0.300120468261437 0.374355327951583 no 1239 0.382042633514326 431 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3329 9141233 27.5565 µM 0.299340281463072 0.374672486311179 no 1240 0.382340211304684 423 4909101 YNL103W MET4
SGTC_1261 0712-0010 12.7 µM 0.299285722539247 0.374694668557428 no 1241 0.382361023697522 429 2840123
SGTC_2431 5490079 200 µM 0.29875371241399 0.374910991827682 no 1242 0.382563985456512 418 5722345
SGTC_1214 0358-0031 63.7 µM 0.296394291952649 0.375870840961953 no 1243 0.383464491983371 418 4301366
SGTC_3197 9113331 49.47 µM 0.295142230428662 0.376380511697357 no 1244 0.383942615291511 374 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2192 5915882 198.485 µM 0.294467359638735 0.376655317632924 no 1245 0.384200400771488 406 2876149
SGTC_2051 5263410 176 µM 0.293744096073425 0.376949898401763 no 1246 0.384476728078213 407 227584
SGTC_866 0495-0101 262 µM 0.29137828900092 0.377913976578484 no 1247 0.38538100869357 419 635694
SGTC_1515 3460-0031 42.1 µM 0.289421868036062 0.378711802959487 no 1248 0.386129281228112 422 2876596
SGTC_2089 5281248 129.67 µM 0.288823935225253 0.378955742661768 no 1249 0.386358057333178 400 2737878
SGTC_1531 st059297 52.4 µM 0.287672455090018 0.379425649809745 no 1250 0.38679873838401 401 7566702
SGTC_963 1269-2853 151 µM 0.286861758290032 0.379756593723405 no 1251 0.387109086422071 382 3668223
SGTC_2737 bleomycin 30.5 nM 0.286546276413062 0.379885404052021 no 1252 0.387229877582104 438 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_440 fluspirilene 35.1 µM 0.286533992270199 0.379890419901324 no 1253 0.387234581134607 419 3396 An atypical antipsychotic.
SGTC_2736 butenafine 14.65 µM 0.28438318723447 0.380768945302524 no 1254 0.388058370994335 416 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_966 1300-0360 30.2 µM 0.283820681375253 0.38099881008384 no 1255 0.388273902274491 423 70588
SGTC_3290 9121031 71.43 µM 0.282307236904608 0.381617478773102 no 1256 0.388853968462882 411 17014854
SGTC_1687 st020778 55.3625 µM 0.282303965672125 0.381618816321933 no 1257 0.388855222515073 430 4259299
SGTC_3212 9128307 49.47 µM 0.281065428417019 0.382125333644867 no 1258 0.389330108433275 384 27243542
SGTC_1002 4049-0206 172 µM 0.280759380573535 0.382250527366219 no 1259 0.389447480273248 410 4662749
SGTC_2950 9072895 21.46 µM 0.280620142745588 0.382307488881997 no 1260 0.389500882452676 383 17332245
SGTC_1865 st057639 52.2 µM 0.280060937749058 0.382536282560769 no 1261 0.389715376539676 421 688818
SGTC_1286 0929-0070 131 µM 0.278322919897699 0.383247638335121 no 1262 0.390382241696078 407 1420408
SGTC_1067 clotrimazole 1.36 µM 0.277631535723374 0.383530725568822 no 1263 0.390647610724335 399 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2967 9089538 49.85 µM 0.275760185285012 0.38429726150603 no 1264 0.391366132951973 412 728216
SGTC_1770 st043884 66.3 µM 0.275483634971997 0.384410579532482 no 1265 0.391472348501287 446 670149
SGTC_1569 carminic acid 40.6 µM 0.275197086616059 0.38452800473353 no 1266 0.391582412566803 446 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1609 st001574 46.4 µM 0.273746871342326 0.385122453538431 no 1267 0.392139577463906 462 3960012
SGTC_1091 telmisartan 47.6 µM 0.273745560630377 0.385122990926649 no 1268 0.392140081132607 427 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2148 5546263 113.568 µM 0.273174591744707 0.385357107533777 no 1269 0.392359505140006 409 792097
SGTC_1479 0549-0158 134 µM 0.272977171735041 0.385438066158907 no 1270 0.392435381846095 400 5440202
SGTC_1087 pterostilbene 9.05 µM 0.271361400179523 0.38610085422727 no 1271 0.393056543382344 416 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3019 9081971 49.47 µM 0.270917702173452 0.386282917039447 no 1272 0.393227164821379 421 16451803
SGTC_2718 lomofungin 53.02 µM 0.270762354639367 0.386346666786935 no 1273 0.39328690764446 430 5351222 A RNA synthesis inhibitor.
SGTC_1631 benzylvanillin 81.9 µM 0.269093014232695 0.387031904935752 no 1274 0.393929053034994 391 75506
SGTC_2776 terbinafine 19.92 µM 0.265905934922392 0.3883411277547 no 1275 0.395155827096836 406 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1458 k015-0034 6.33 µM 0.265391537009856 0.388552557073239 no 1276 0.3953539274915 430 3598957
SGTC_1504 k297-0033 30 µM 0.265023590643756 0.388703811715677 no 1277 0.395495644350857 402 4388117
SGTC_1033 k072-0102 21.3 µM 0.26358835169462 0.389293967905161 no 1278 0.396048567595167 439 5965931
SGTC_1390 3413-2614 145 µM 0.262564258798688 0.389715221116282 no 1279 0.396443225519401 453 3421432
SGTC_2591 skatole 100 µM 0.260958113355552 0.390376158272604 no 1280 0.397062404490418 441 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_791 1348-1292 225 µM 0.260531042334828 0.390551953626519 no 1281 0.397227086749786 425 5437054
SGTC_89 0302-0250 142.109 µM 0.260053185276989 0.390748680574097 no 1282 0.397411374263254 452 4203518 YLR208W SEC13
SGTC_313 3474-0040 5.03 µM 0.25997524786067 0.390780768952709 no 1283 0.397441433317448 442 1043375 YIL048W NEO1
SGTC_2886 9058944 51.95 µM 0.259597788602973 0.390936186928001 no 1284 0.397587021152233 428 4949929
SGTC_698 k064-0052 127 µM 0.258635881455589 0.391332328680158 no 1285 0.397958097781567 458 5088751
SGTC_1118 chelidonine 707.474 nM 0.258114758329283 0.391546989675519 no 1286 0.398159170956055 443 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_3111 9122088 49.47 µM 0.257975087393848 0.391604528531013 no 1287 0.398213066999496 449 16876704
SGTC_2356 9061756 188.97 µM 0.257393413216676 0.391844180585675 no 1288 0.39843754356695 417 20104043
SGTC_65 0798-0905 34.986 µM 0.257305097084456 0.391880570771559 no 1289 0.398471628994068 453 3602145
SGTC_551 k048-0028 34.9 µM 0.256536533807085 0.392197293024192 no 1290 0.398768287062106 432 6836383
SGTC_2463 5473429 200 µM 0.254969650155261 0.392843221384784 no 1291 0.39937327017179 439 5399405
SGTC_1117 retinoic acid 1.10837 µM 0.254512581322341 0.393031698039366 no 1292 0.399549792776338 445 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2073 5212005 126 µM 0.254091135764895 0.393205507323805 no 1293 0.399712575665972 459 691789
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.254054435952788 0.39322064378175 no 1294 0.399726751754118 407 5379071
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.252237723722771 0.3939701292788 no 1295 0.400428660601555 419 5377381
SGTC_2045 5106652 78.05 µM 0.25193429345331 0.39409534794458 no 1296 0.400545925986638 456 673349
SGTC_272 doxorubicin 8.13 µM 0.251915781610619 0.394102987709074 no 1297 0.400553080468737 438 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1377 2944-0135 198 µM 0.250424664009647 0.394718499649173 no 1298 0.401129479005261 402 1894137
SGTC_2931 9014674 55.67 µM 0.249868200866927 0.394948267089847 no 1299 0.401344637679121 416 2996810
SGTC_2496 diffractaic acid 79.83 µM 0.249134050986432 0.395251458491742 no 1300 0.401628545395903 418 94870 An apoptosis inducer which activates caspases.
SGTC_54 0159-0055 9 µM 0.248732211899782 0.395417438063388 no 1301 0.401783965116964 442 3319099
SGTC_1433 4060-0023 7.6 µM 0.248662395390754 0.39544627769688 no 1302 0.401810969705383 425 3840627
SGTC_898 1000-0849 28.3 µM 0.248265050214461 0.395610422972531 no 1303 0.401964669254109 453 6751807
SGTC_404 fumagillin 50 µM 0.247870394774218 0.395773475435891 no 1304 0.402117343378546 424 12015870 A methionine aminopeptidase binder.
SGTC_1873 rapamycin 2 nM 0.246979814059457 0.396141487126163 no 1305 0.402461923136982 430 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2830 7992007 71.43 µM 0.246658357141892 0.396274344448555 no 1306 0.40258631853205 424 1952075
SGTC_1263 0774-1208 64.8 µM 0.246223051412828 0.396454274393521 no 1307 0.402754786150958 450 906585
SGTC_506 n9-isopropylolomoucine 153 µM 0.245219766762779 0.396869057559689 no 1308 0.403143135946465 448 6610355
SGTC_889 0919-1524 82.7 µM 0.244484843957987 0.397172967256595 no 1309 0.403427669329536 417 3905452
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.244147668103458 0.397312419151337 no 1310 0.403558227759225 407 115019
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.243979872964516 0.397381822104024 no 1311 0.403623204003338 417 6708739 YPR165W RHO1
SGTC_1892 st058411 7.36 µM 0.243610454979568 0.39753463117788 no 1312 0.403766265155158 443 3934738
SGTC_1078 idebenone 36.1 µM 0.243398417328496 0.397622347269413 no 1313 0.403848384869871 439 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2521 angolensin 13.4 µM 0.241934074942931 0.398228259979098 no 1314 0.404415623152107 435 821428 A flavenoid.
SGTC_2626 ethyl orsellinate 100 µM 0.241824846295241 0.398273466250197 no 1315 0.404457942822538 425 75653 A natural product.
SGTC_306 1672-3436 11.6 µM 0.241619677676362 0.398358382721349 no 1316 0.404537436605061 451 6797378
SGTC_2142 5622915 118.518 µM 0.240586390516616 0.39878611915946 no 1317 0.404937849601302 430 5322196
SGTC_865 0488-0499 301 µM 0.240584351244352 0.398786963450849 no 1318 0.404938639945936 441 9634651
SGTC_878 0828-0289 13.7 µM 0.239347082286881 0.399299299796288 no 1319 0.405418229868158 429 745350 YLR208W SEC13
SGTC_2003 4023581 200 µM 0.238905304712118 0.399482275994971 no 1320 0.405589506044809 433 16641307
SGTC_1159 4092-0538 61.2 µM 0.237906492021336 0.399896047297849 no 1321 0.4059768100802 426 717301
SGTC_504 lovastatin 124 µM 0.237823593808426 0.399930394032491 no 1322 0.406008959200307 444 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2121 5257820 149.641 µM 0.23772125248722 0.399972797585005 no 1323 0.406048649511884 465 791256
SGTC_1052 3253-3998 198 µM 0.237499222438815 0.400064796375459 no 1324 0.406134761176369 418 5450317
SGTC_3304 9125678 46.087 µM 0.236565476210701 0.400451757471387 no 1325 0.406496952996784 436 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_3298 9116858 71.43 µM 0.236497969539145 0.400479737233203 no 1326 0.406523141336678 451 2506942
SGTC_2753 fluvastatin 17.09 µM 0.236267024569161 0.400575461785575 no 1327 0.406612736611229 425 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_48 0382-0018 55 µM 0.235372517178458 0.400946283127749 no 1328 0.406959807523932 385 762596
SGTC_222 nsc-310342 10.666 µM 0.234910601479899 0.401137806956949 no 1329 0.407139060500624 462 432556
SGTC_1526 st051518 75 µM 0.230090250281124 0.403137875720943 no 1330 0.40901082040792 425 673993
SGTC_2868 9035608 32.47 µM 0.230022733345082 0.403165908104806 no 1331 0.409037052326682 437 6462614
SGTC_208 k072-0098 12.366 µM 0.229335844810018 0.403451125893249 no 1332 0.409303947825209 437 5948901
SGTC_1209 2323-2347 50.3 µM 0.229133814363831 0.403535025089271 no 1333 0.409382456220965 434 5412760
SGTC_3092 9117248 49.47 µM 0.229032363578669 0.403577157242122 no 1334 0.409421881047825 451 17141857
SGTC_3196 9111891 49.47 µM 0.228244477904795 0.403904401435319 no 1335 0.409728092742057 461 18891510
SGTC_2181 6316240 54.2555 µM 0.227968734130542 0.404018946072531 no 1336 0.409835273553225 420 12779990
SGTC_3116 9124943 49.47 µM 0.227809189669508 0.404085224990563 no 1337 0.409897291103395 416 41905195 YPL160W CDC60
SGTC_2594 a-mangostin 100 µM 0.227772319106288 0.404100542373095 no 1338 0.409911623617083 461 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_820 1582-0060 59.9 µM 0.226510486585023 0.404624842293677 no 1339 0.410402202025722 423 3848840
SGTC_1957 st077035 62.4 µM 0.22647432408054 0.404639870587482 no 1340 0.41041626344543 463 705593
SGTC_2040 5100729 123 µM 0.226470156438956 0.404641602571205 no 1341 0.410417883997601 453 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2619 obliquin 87.91 µM 0.225984136476623 0.404843594996566 no 1342 0.410606879230951 464 6708593 A bioactive alkalod. YER133W GLC7
SGTC_560 2332-1943 155 µM 0.225399715008952 0.405086517174104 no 1343 0.41083416666468 460 21177716
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.224057685863627 0.405644486852741 no 1344 0.41135620860822 446 279621
SGTC_24 0417-1663 219 µM 0.222918296837856 0.406118356295458 no 1345 0.411799547925323 448 4329390
SGTC_1031 k035-0009 16 µM 0.222329046765812 0.406363478144337 no 1346 0.412028870920138 460 5180959
SGTC_2766 oltipraz 83.91 µM 0.22179500923217 0.406585663863532 no 1347 0.412236732381691 419 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3016 9080866 49.47 µM 0.221393300513133 0.406752814152527 no 1348 0.412393104215654 465 17066299
SGTC_988 1497-1057 103 µM 0.220432870359265 0.407152516255633 no 1349 0.412767024037982 467 3533044
SGTC_3130 9127414 49.47 µM 0.220190294765388 0.407253484225681 no 1350 0.412861477406406 445 1494646
SGTC_1653 st012112 65 µM 0.220046141771223 0.407313488380467 no 1351 0.412917609663835 450 720429
SGTC_3317 9138495 8.753 µM 0.219926631520789 0.407363236561848 no 1352 0.41296414754392 470 17020139
SGTC_1075 aripiprazole 15.2 µM 0.219618619488499 0.40749145871327 no 1353 0.413084094583396 418 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1793 st048256 72.231 µM 0.219274420933501 0.407634756657909 no 1354 0.413218143094835 470 672022
SGTC_216 k038-0035 28.382 µM 0.219201471034732 0.407665129002501 no 1355 0.413246554814247 444 4444231 YPR107C YTH1
SGTC_2602 kawain 100 µM 0.219107615956601 0.407704205935762 no 1356 0.413283109119867 457 5369129
SGTC_2798 7813637 45.45 µM 0.218678952137361 0.407882693482763 no 1357 0.413450072965905 470 956368
SGTC_3107 9121808 49.47 µM 0.218447063473478 0.407979255529715 no 1358 0.413540399741068 419 662681
SGTC_1275 0867-0008 21.1 µM 0.218092591129358 0.408126874128825 no 1359 0.413678484947456 448 3422836
SGTC_1223 0764-0573 147 µM 0.2180702507213 0.408136178140043 no 1360 0.413687188043008 428 1609797
SGTC_672 1441-0018 53.7 µM 0.217260525196284 0.408473435877898 no 1361 0.414002659327653 419 251141
SGTC_1981 st071826 47 µM 0.217247537217511 0.408478846037376 no 1362 0.414007719932593 425 11838600
SGTC_1534 6-azauridine 81.6 µM 0.216922550850311 0.408614225208218 no 1363 0.414134351488929 455 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_749 1000-0129 128 µM 0.216031243663249 0.408985571869037 no 1364 0.414481696809898 457 708470
SGTC_1943 st076331 65.2 µM 0.21535090756239 0.40926907633142 no 1365 0.414746871036913 455 24208415
SGTC_425 3825-7017 13.1 µM 0.215258772942896 0.409307473618411 no 1366 0.414782785286539 483 3397440
SGTC_842 0271-0008 11.1 µM 0.215223281427022 0.409322265010819 no 1367 0.414796620136874 449 1221709
SGTC_1336 1486-0901 104 µM 0.214669479188298 0.409553083534726 no 1368 0.415012509946005 416 5006114
SGTC_2009 4012297 12.05 µM 0.212896860243075 0.410292101526503 no 1369 0.415703705705231 414 45595307
SGTC_619 1652-1634 108 µM 0.212595348766481 0.410417835683317 no 1370 0.415821299831923 452 5400454
SGTC_767 0929-0023 86 µM 0.211843106036757 0.410731570677924 no 1371 0.416114718941419 435 1204563
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.21144372772515 0.410898161087925 no 1372 0.4162705190935 421 5282362
SGTC_1772 st048439 82.2 µM 0.210558295083296 0.411267553858545 no 1373 0.416615979178593 458 2927068 YDL195W SEC31
SGTC_2446 5162541 200 µM 0.209366205021774 0.411765004956938 no 1374 0.417081186303681 431 1549321
SGTC_2641 levomentholum 100 µM 0.208938108165078 0.411943681529507 no 1375 0.417248277310979 473 16666
SGTC_2424 5537928 59.2 µM 0.208269060050538 0.41222296148531 no 1376 0.417509444219436 469 5382802
SGTC_1456 k015-0012 13 µM 0.205521929786336 0.413370157344403 no 1377 0.418582183142846 463 2989616
SGTC_1021 4476-0760 85.3 µM 0.205160703943504 0.413521059759404 no 1378 0.418723285039336 440 746768
SGTC_1941 st076221 61.8 µM 0.205003810451944 0.413586606134428 no 1379 0.418784573971651 424 2828568
SGTC_2659 sanguinarine 24.21 µM 0.204497731814835 0.41379805017333 no 1380 0.418982282147461 457 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_497 capsazepine 133 µM 0.204054137666259 0.413983408210371 no 1381 0.419155596531626 431 2733484 A calcium channel blocker.
SGTC_2076 5212012 200 µM 0.203440088219015 0.414240023464524 no 1382 0.419395534510022 443 604802
SGTC_1172 0370-0043 85 µM 0.20331535695857 0.414292153946521 no 1383 0.419444276541325 431 376585
SGTC_1629 st005085 44.9 µM 0.203145802160354 0.414363020506526 no 1384 0.419510536534859 484 24207091
SGTC_1644 st010134 20.9 µM 0.202173581300436 0.414769420462278 no 1385 0.419890512862269 478 3818134
SGTC_2875 9039966 71.43 µM 0.200677708996484 0.415394891032414 no 1386 0.420475295388833 458 6463691
SGTC_1315 1237-0019 3.69 µM 0.200593745553544 0.415430005121139 no 1387 0.420508124498774 469 825140
SGTC_177 1327-0068 8.361 µM 0.199618396411152 0.415837952255984 no 1388 0.420889519547249 428 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1352 1496-0991 99 µM 0.198515044644442 0.416299546783436 no 1389 0.421321057527176 487 3000039
SGTC_2682 pyrogallin 40.03 µM 0.196588799897989 0.417105680436026 no 1390 0.422074667982134 447 822798 An ATP competetive kinase inhibitor.
SGTC_171 k064-0041 9.68 µM 0.196394006110466 0.417187221125049 no 1391 0.422150893670891 427 53325
SGTC_1782 st039423 80.636 µM 0.195237163329383 0.417671548846467 no 1392 0.422603643343908 450 2068169
SGTC_19 0279-0214 38.434 µM 0.195198932664167 0.417687556762625 no 1393 0.42261860729984 449 3566274 YBR002C RER2
SGTC_2202 7226349 200 µM 0.193882615723388 0.41823880705185 no 1394 0.423133898027065 430 844334
SGTC_1357 1503-1303 39.5 µM 0.193558367704295 0.418374621096954 no 1395 0.423260849684275 439 292895
SGTC_474 dl-dihydrosphingosine 5 µM 0.192987483472747 0.418613764462665 no 1396 0.423484385283963 425 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1874 staurosporine 7.6 µM 0.191692571579517 0.419156314336292 no 1397 0.423991512551119 481 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1677 st019204 53.9 µM 0.191526863518527 0.419225754802655 no 1398 0.424056418020563 418 3945625
SGTC_211 3455-0679 143.504 µM 0.189666217541577 0.420005636395013 no 1399 0.424785347370032 432 748649
SGTC_318 1488-0629 67.2 µM 0.189173322419036 0.420212283992031 no 1400 0.424978487879168 455 3662576
SGTC_2670 beta-carotene 100 µM 0.189122138853646 0.420233744100203 no 1401 0.424998545146063 445 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_731 3966-0296 387 µM 0.188119830178994 0.420654037108169 no 1402 0.425391358189119 452 660956
SGTC_1079 idarubicin 2.36 µM 0.18760168430396 0.420871344089519 no 1403 0.425594452902497 478 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3335 9143315 29.6265 µM 0.186784091677203 0.421214286091165 no 1404 0.425914960202338 428 4899691
SGTC_2773 thioridazine 9.09 µM 0.186100238502924 0.421501176550428 no 1405 0.426183077441555 482 5452 An antipsychotic.
SGTC_2532 xanthone 78.9 µM 0.184897642624263 0.422005791230364 no 1406 0.426654660012978 478 7020 An insecticide.
SGTC_850 0388-0143 75.9 µM 0.18475033515176 0.422067610934607 no 1407 0.426712431974574 435 67273
SGTC_2461 5755302 26.15 µM 0.184358864558357 0.422231906540206 no 1408 0.426865968986874 482 2788904
SGTC_129 0088-0017 176.636 µM 0.182971155285972 0.42281442063381 no 1409 0.427410325633533 473 182446
SGTC_725 1497-0963 19 µM 0.182570786045307 0.422982513728892 no 1410 0.427567404194647 483 3549977
SGTC_1803 st050068 52.4 µM 0.181817102921108 0.423298981974644 no 1411 0.427863131021868 470 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1025 k007-0731 70 µM 0.180920404825108 0.423675566035418 no 1412 0.428215026205179 448 6256118
SGTC_627 1391-0720 175 µM 0.180390600002204 0.423898099632688 no 1413 0.428422966694609 488 997839
SGTC_1560 lithocholic acid 53.1 µM 0.179173294064813 0.424409495736842 no 1414 0.428900816314722 477 9903 A bile acid which acts as a detergent.
SGTC_2069 5228469 200 µM 0.17655188751286 0.425511192384588 no 1415 0.429930194240816 461 2835210
SGTC_209 4077-0173 175.592 µM 0.175980042636668 0.425751598822246 no 1416 0.43015481071026 471 15993494
SGTC_564 3555-0129 330 µM 0.175641048842502 0.425894126540971 no 1417 0.430287975660757 479 563260
SGTC_394 menadione 8.33 µM 0.17518245630122 0.42608695417381 no 1418 0.430468134503785 479 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_772 k072-0172 35.3 µM 0.174978609559742 0.426172672724347 no 1419 0.430548220684426 420 5861980
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.173964492656119 0.426599165599183 no 1420 0.430946683718499 471 688751
SGTC_1603 st002045 67.8 µM 0.172900472266409 0.427046737954446 no 1421 0.431364830214921 470 5887985
SGTC_140 0062-0056 502.533 µM 0.172399154336099 0.427257646246182 no 1422 0.431561868483944 441 3758964
SGTC_2958 9077254 16.72 µM 0.171504017522942 0.427634288830286 no 1423 0.431913735859602 447 16457351
SGTC_1119 parthenolide 318.541 nM 0.170700975524943 0.427972237243061 no 1424 0.432229447864934 476 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_577 r071-0003 38.6 µM 0.170550181484721 0.428035702597155 no 1425 0.432288736631587 477 4568517 YMR134W ERG29
SGTC_2141 5621638 7.665 µM 0.170468763468226 0.428069970131604 no 1426 0.432320748966924 473 2856238
SGTC_2266 7929956 200 µM 0.170252688550926 0.428160915220652 no 1427 0.432405708517133 484 2967153
SGTC_2252 omeprazole 400 µM 0.16982903992596 0.428339238343904 no 1428 0.432572294053382 482 4594 A proton pump inhibitor.
SGTC_2219 9098279 200 µM 0.169626595038554 0.428424457066416 no 1429 0.432651902912943 465 902349
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.168635762123479 0.428841594037291 no 1430 0.433041574643065 462 521171
SGTC_2584 androsterone 48.74 µM 0.168182949590289 0.429032252923266 no 1431 0.433219677068526 472 2754130 A steroid.
SGTC_2813 7971799 71.43 µM 0.168153421097021 0.429044686612406 no 1432 0.433231291830443 463 2234054
SGTC_2004 4023728 41.89 µM 0.167463700434969 0.429335130249278 no 1433 0.433502603509983 497 360084 YDR527W RBA50
SGTC_1086 cerivastatin 2.18 µM 0.164977349688131 0.430382457161108 no 1434 0.434480905040382 462 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2435 5706476 10.6 µM 0.164923265840815 0.430405244401344 no 1435 0.434502189830423 471 5725375
SGTC_1356 1502-0781 85.8 µM 0.164837785467528 0.430441260466361 no 1436 0.434535831163768 445 567702
SGTC_2306 7482397 179.52 µM 0.164476792997692 0.430593366417625 no 1437 0.434677907223909 487 891448
SGTC_1939 st074455 53.6 µM 0.164380106889438 0.430634107333854 no 1438 0.434715961476558 494 1644229
SGTC_1937 st074714 47.2 µM 0.163132076641506 0.431160059713798 no 1439 0.435207222282908 457 17250970
SGTC_3355 9151058 44.0485 µM 0.163025428996781 0.431205009478449 no 1440 0.435249206530351 483 17015728
SGTC_2783 7738165 71.43 µM 0.160534141176295 0.432255287801286 no 1441 0.436230164798226 486 17201110
SGTC_2518 prenyletin 46.28 µM 0.160155068134426 0.432415139760438 no 1442 0.436379461434449 480 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2139 5578692 56.4705 µM 0.159646562675784 0.432629589666449 no 1443 0.436579748821647 478 650991 YMR113W FOL3
SGTC_2617 dihydrotanshinone i 20.83 µM 0.158481475650499 0.433121011730431 no 1444 0.437038708240284 466 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_3208 9114115 49.47 µM 0.15743459193546 0.433562665069951 no 1445 0.43745117647326 478 650895
SGTC_3229 9132204 49.47 µM 0.155943956428607 0.434191668939241 no 1446 0.438038598451872 471 17682924
SGTC_2281 7943571 200 µM 0.155683091984533 0.434301763158604 no 1447 0.438141412647979 490 1244024
SGTC_1316 1272-0050 65.9 µM 0.154520083998136 0.434792656426747 no 1448 0.438599838325815 474 7340392
SGTC_2799 7812892 81.82 µM 0.152021308505286 0.435847702018958 no 1449 0.43958506461262 485 20205235
SGTC_1271 0832-2808 169 µM 0.15162816811946 0.43601373750784 no 1450 0.439740107667048 485 3663794
SGTC_1057 3448-5381 134 µM 0.151481909533227 0.436075509965886 no 1451 0.439797790130136 478 5497911
SGTC_514 4466-0038 2.65 nM 0.151387732523601 0.436115286544118 no 1452 0.439834932980763 488 5722064
SGTC_534 k292-0788 63.4 µM 0.150539471766934 0.436473586817266 no 1453 0.440169505788576 483 4146317
SGTC_2165 5727197 32.143 µM 0.147978739879488 0.437555539703265 no 1454 0.441179773312032 480 1361712
SGTC_2689 tacrolimus 100 µM 0.146622127103455 0.438128921523989 no 1455 0.441715143768399 494 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2560 caryophyllene 100 µM 0.146590627100917 0.438142236766978 no 1456 0.441727576123768 459 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1126 isoteolin 1.0172 µM 0.145545420114588 0.438584091751301 no 1457 0.442140128721094 445 133323
SGTC_853 0419-0306 21 µM 0.145365772847972 0.438660044281257 no 1458 0.442211043446075 487 762713
SGTC_2274 7947094 46.08 µM 0.144267472544224 0.439124440398611 no 1459 0.442644631359954 478 2971028
SGTC_182 3448-4371 550.524 µM 0.143918990222505 0.439271807293598 no 1460 0.442782219885805 479 3491403
SGTC_97 0535-0701 19.132 µM 0.14284280398422 0.439726960107835 no 1461 0.443207165497544 461 2832013 YGL099W LSG1
SGTC_1421 4029-0249 71.4 µM 0.142562372263491 0.439845576562769 no 1462 0.443317908223258 480 2894095
SGTC_507 nimesulide 162 µM 0.142235159129252 0.439983987353062 no 1463 0.44344713056543 487 4495 A COX2 inhibitor.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.141347457876733 0.440359520886322 no 1464 0.443797729981189 460 688788
SGTC_1590 st077108 57.8 µM 0.140775103781288 0.440601678287749 no 1465 0.444023805739931 494 5489485
SGTC_1003 4049-0218 100 µM 0.140622654672731 0.440666181759928 no 1466 0.444084025118551 496 295161
SGTC_1128 3448-9350 235 µM 0.138697063662016 0.441481062762063 no 1467 0.444844769265789 430 619386
SGTC_1205 4161-2785 76 µM 0.138076539916017 0.441743711982685 no 1468 0.445089963299309 449 3498106
SGTC_73 0327-0325 16.231 µM 0.138009661199117 0.441772021282995 no 1469 0.445116391041562 482 53298
SGTC_2185 6113692 200 µM 0.137329424207269 0.442059977790167 no 1470 0.445385206805158 470 874150
SGTC_2204 7233102 200 µM 0.136657156819114 0.442344590705966 no 1471 0.445650897818048 487 2172480
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.135920254790683 0.442656601701978 no 1472 0.445942161531722 453 94937 An inhibitor of serotonin biosynthesis.
SGTC_337 1315-0038 354 µM 0.134359436058061 0.443317583716997 no 1473 0.446559178033916 502 1626437
SGTC_2751 anetholtrithion 17.25 µM 0.133713559808665 0.44359114833153 no 1474 0.446814541140416 483 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1923 st058458 19.1 µM 0.133609300630771 0.443635310431891 no 1475 0.446855764648226 499 3534982
SGTC_2339 9000433 200 µM 0.133109575720539 0.443846993607956 no 1476 0.447053361105066 473 2988954
SGTC_3081 9117243 49.47 µM 0.132866930757019 0.443949783653213 no 1477 0.447149310205411 478 45595589
SGTC_457 grayanotoxin iii 135 µM 0.130134615458967 0.445107514592054 no 1478 0.448229961898565 487 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_441 propafenone 146 µM 0.12951428054982 0.445370427197041 no 1479 0.44847536293743 497 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2677 mitomycin C 100 µM 0.129506072617239 0.445373906074304 no 1480 0.448478610082267 480 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2524 avocatin b 10.57 µM 0.129346271419865 0.445441637579606 no 1481 0.448541829811573 498 6710748
SGTC_2080 5212524 12.4 µM 0.128747612622307 0.445695392383168 no 1482 0.448778679736216 488 260183
SGTC_1619 st003326 88.7 µM 0.128522417394497 0.445790852136941 no 1483 0.448867779411165 486 2849032
SGTC_1828 st055811 49 µM 0.127048019012692 0.446415923708038 no 1484 0.449451196387241 507 5877589
SGTC_1176 0848-0131 83.3 µM 0.124638288852715 0.447437815424057 no 1485 0.450404957307535 506 6769040
SGTC_39 0986-0283 58.349 µM 0.123033022528728 0.448118753128246 no 1486 0.451040474206581 472 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2293 7624732 200 µM 0.122988184066629 0.448137775353778 no 1487 0.451058227338785 496 894453
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.122028849275155 0.448544791112674 no 1488 0.451438085293488 493 2333 A French combination drug.
SGTC_614 0462-0418 107 µM 0.120958152471457 0.44899911823556 no 1489 0.45186209062025 487 5188303
SGTC_917 harmaline 728.087 nM 0.120467234144143 0.449207451250871 no 1490 0.452056516975326 470 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2546 rhodinyl acetate 100 µM 0.118617596578412 0.449992514803729 no 1491 0.452789161863006 484 6708682
SGTC_2146 5545642 200 µM 0.117599613033092 0.450424673311829 no 1492 0.453192455787064 482 825326
SGTC_326 k292-0812 17.5 µM 0.115760441824412 0.451205594444 no 1493 0.453921201265019 501 3579357
SGTC_1284 0929-0043 16 µM 0.115501355107916 0.451315619185028 no 1494 0.454023873222828 488 1239883
SGTC_536 3852-0578 10.6 µM 0.114634095770593 0.451683939968945 no 1495 0.454367576664546 455 2869208
SGTC_2846 9008642 19.48 µM 0.114104059927382 0.451909064088914 no 1496 0.454577651945081 503 2992898
SGTC_2544 sphondin 68.51 µM 0.113990927765069 0.451957117143429 no 1497 0.454622492580286 507 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1626 st003712 1.76 µM 0.112222250989555 0.452708456313099 no 1498 0.455323593435039 490 24207035
SGTC_341 1486-1430 230 µM 0.110758878632201 0.453330229405488 no 1499 0.455903777374692 495 2054753 YPL210C SRP72
SGTC_710 3448-4187 58 µM 0.110545426542452 0.453420932781056 no 1500 0.455988412715462 474 3946412
SGTC_3180 9109287 49.47 µM 0.109806100179111 0.453735117570878 no 1501 0.456281576529974 489 18891271
SGTC_2946 9065502 71.43 µM 0.108746698375629 0.45418537233075 no 1502 0.456701700757069 477 16489101
SGTC_1181 1222-0449 220 µM 0.108559452167702 0.454264959698512 no 1503 0.456775961547349 480 658318
SGTC_2481 5478948 45.16 µM 0.107959008639373 0.454520185353898 no 1504 0.45701410423393 494 77792
SGTC_25 0118-0223 35.662 µM 0.107102563100658 0.454884260174051 no 1505 0.457353806902744 498 5333628
SGTC_2951 9072950 58.06 µM 0.107070953013687 0.454897698342555 no 1506 0.457366345403329 503 16488155
SGTC_870 0573-2213 57.6 µM 0.10694392376487 0.454951701892108 no 1507 0.457416733427731 509 3916321
SGTC_3185 9108267 49.47 µM 0.106658751402633 0.455072939362697 no 1508 0.457529853741717 487 4910486
SGTC_442 cape 100 µM 0.105702758410042 0.455479398316075 no 1509 0.457909095860096 504 5281787
SGTC_262 fenpropimorph 62.5 µM 0.105465163392973 0.455580423690892 no 1510 0.45800335568778 504 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1027 k015-0025 8.67 µM 0.105128558506238 0.455723552966844 no 1511 0.458136899225144 451 3598955
SGTC_1707 st032323 6.317 µM 0.105106072394719 0.455733114592302 no 1512 0.458145820461077 493 3132057 YMR211W DML1
SGTC_1994 st072947 40.9 µM 0.104769964559447 0.455876038631271 no 1513 0.458279171829847 500 5286565 YDL195W SEC31
SGTC_2506 ethyl hematommate 54.16 µM 0.10445677003389 0.456009224321676 no 1514 0.458403436530034 469 3940691 An allergen.
SGTC_3207 9114163 49.47 µM 0.104314811745353 0.45606959358518 no 1515 0.458459761983718 491 849233
SGTC_1450 4112-4260 37.6 µM 0.104220897761574 0.456109532057467 no 1516 0.458497025132532 504 1633175
SGTC_2436 5633522 8.09 µM 0.103407556572716 0.456455437335971 no 1517 0.458819757511161 491 5724242
SGTC_2839 9003951 25.97 µM 0.102357381129452 0.456902114458549 no 1518 0.4592365054343 507 2990634
SGTC_2860 9025725 38.96 µM 0.102158747380146 0.456986606627664 no 1519 0.459315335603588 508 40546248
SGTC_676 falcarinol 140 µM 0.101413889012855 0.457303461809695 no 1520 0.459610955739613 510 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_635 k038-0028 24.7 µM 0.100714404772471 0.457601040016106 no 1521 0.459888588082205 505 4035102
SGTC_830 4076-0286 57.8 µM 0.0999688755494557 0.45791823308344 no 1522 0.460184517672128 498 6866659
SGTC_2125 5246583 200 µM 0.099635406077069 0.458060119784197 no 1523 0.460316891844619 502 835267
SGTC_978 1416-0512 87.4 µM 0.0990637860068529 0.45830334873097 no 1524 0.460543812595163 495 6814003
SGTC_2401 5128683 200 µM 0.0983690857243143 0.45859897031017 no 1525 0.460819610807591 498 708373
SGTC_874 0599-0792 117 µM 0.0961223220681348 0.459555210266568 no 1526 0.461711711472905 503 765305
SGTC_1280 0880-0253 10.1 µM 0.0960834279339626 0.459571765986892 no 1527 0.461727156499251 504 6836607
SGTC_3280 9140961 49.47 µM 0.0960770905743866 0.459574463561047 no 1528 0.461729673097202 471 4901226
SGTC_1213 1315-0166 115 µM 0.0943193762802006 0.46032272742434 no 1529 0.462427729241103 458 768401
SGTC_1875 nocodazole 6 µM 0.0937874722671209 0.460549188261047 no 1530 0.462638991750027 506 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1960 st011366 51.8 µM 0.0936981163518895 0.460587233253463 no 1531 0.462674483314688 513 3972846
SGTC_511 blebbistatin 171 µM 0.0927510194845116 0.460990499994974 no 1532 0.46305068199027 489 3476986 A myosin inhibitor.
SGTC_389 tpck 16.7 µM 0.0927231897350018 0.461002350302329 no 1533 0.463061736814961 465 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2087 5276107 200 µM 0.0923950315293307 0.461142087391978 no 1534 0.463192093404834 514 144405
SGTC_1318 1280-3875 124 µM 0.0905574820212809 0.461924645160825 no 1535 0.463922108745393 490 373245
SGTC_1557 sumaresinolic acid 42.3 µM 0.0901849243635267 0.462083324477188 no 1536 0.464070132060466 492 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1402 3909-7673 35.9 µM 0.0899090144910609 0.462200843574515 no 1537 0.464179758819737 492 5328014
SGTC_2962 9082311 13.18 µM 0.0897539862697151 0.462266876645962 no 1538 0.464241357090007 498 16459453
SGTC_3289 9119912 71.43 µM 0.0896600928523301 0.462306870326451 no 1539 0.464278664727765 507 17014829
SGTC_1853 st056710 91.2 µM 0.0884737681105978 0.462812215253356 no 1540 0.464750066289862 517 269167
SGTC_117 lucigenin 22.078 µM 0.0880635305374969 0.462986980296813 no 1541 0.464913091071051 503 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2205 7238770 200 µM 0.0876263428831928 0.463173234189875 no 1542 0.465086832058142 501 279867
SGTC_1889 st059080 5.18 µM 0.0873588874689738 0.46328718149109 no 1543 0.465193123722026 483 176925 Isolated from Daphnopsis sellowiana.
SGTC_3105 9121040 49.47 µM 0.0869790740843312 0.463449003206437 no 1544 0.465344072760194 511 41448907
SGTC_2360 9040895 200 µM 0.086503618384811 0.463651582410715 no 1545 0.465533039900366 475 4914414
SGTC_958 1222-0007 33 µM 0.0863029304788785 0.463737093095972 no 1546 0.465612804492371 504 7312461
SGTC_2849 9019321 12.99 µM 0.0853384848974656 0.464148054974491 no 1547 0.465996148293876 514 16489627
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.0849938617854219 0.464294912332887 no 1548 0.466133135319022 498 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1189 1431-2119 7.28 µM 0.0839143867985067 0.464754950147157 no 1549 0.466562250447523 522 3107275
SGTC_2301 7769476 200 µM 0.0838891626557209 0.464765700438132 no 1550 0.466572278067625 487 977820
SGTC_482 fipronil 114 µM 0.083774709987351 0.464814479405383 no 1551 0.466617777913124 494 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2238 6671620 73.2395 µM 0.0837023925595383 0.464845300885557 no 1552 0.466646527417925 467 729941
SGTC_2888 9058547 12.99 µM 0.0835474826328692 0.464911323761282 no 1553 0.466708111826469 493 16476514
SGTC_2173 5763948 167 µM 0.0834815714488667 0.464939415513706 no 1554 0.466734315045509 516 2867177
SGTC_1638 st008370 60.6 µM 0.0819876565383403 0.46557617784217 no 1555 0.46732826453202 508 24207134
SGTC_1744 st037937 38.9 µM 0.0815943197352402 0.465743847403739 no 1556 0.467484659214449 492 1016152
SGTC_2351 9026858 72.31 µM 0.0815025224150162 0.465782979163079 no 1557 0.467521159478677 504 1409300
SGTC_1745 st081495 74 µM 0.0811617723145873 0.46592823848241 no 1558 0.467656650228121 501 13842402 YBL026W LSM2
SGTC_2222 6885208 172.143 µM 0.0811572853018901 0.465930151294004 no 1559 0.467658434401453 500 609514
SGTC_1743 st037606 46.3785 µM 0.0796712094275565 0.466563707834473 no 1560 0.468249379095776 497 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_354 2783-3500 4.88 µM 0.0794380880976868 0.466663101837554 no 1561 0.468342087213684 510 6740761
SGTC_2466 5983409 37.09 µM 0.0777202675571909 0.467395578398872 no 1562 0.469025285845397 501 2879657
SGTC_3104 9120930 49.47 µM 0.0768125652471563 0.467782666290259 no 1563 0.469386327325686 518 17014836
SGTC_2273 7815444 169.05 µM 0.0766989838618405 0.467831105004065 no 1564 0.469431506461038 528 2824616
SGTC_849 0386-0493 241 µM 0.0759607873373794 0.468145933044556 no 1565 0.469725147598519 508 726119
SGTC_760 0568-0725 82.9 µM 0.0758394263285653 0.468197693326438 no 1566 0.469773424378564 528 3916171
SGTC_1273 0849-0096 14.1 µM 0.075671846189979 0.468269166878983 no 1567 0.469840087619033 509 5286025
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.0733938541136893 0.469240839468645 no 1568 0.470746354057081 497 803109
SGTC_1158 4092-0494 91.8 µM 0.0733690062487813 0.46925143929235 no 1569 0.470756240267303 517 1148199
SGTC_625 k213-0058 121 µM 0.0729973072448754 0.469410004563951 no 1570 0.470904130151526 520 3655420
SGTC_2557 derrustone 83.84 µM 0.0726803064082087 0.469545239655858 no 1571 0.471030260152641 512 629853 An antioxidant.
SGTC_430 0958-0115 16.4 µM 0.0715402392354072 0.470031630356021 no 1572 0.471483900151921 492 6833180
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.071527802146044 0.470036936681268 no 1573 0.471488849154191 500 6312947
SGTC_1886 st057356 49.9 µM 0.0714595821203271 0.47006604307513 no 1574 0.471515995540772 494 24207747
SGTC_3132 9126706 49.47 µM 0.0712227151930567 0.470167104701092 no 1575 0.471610251606287 527 850858
SGTC_2735 sertaconazole 140 nM 0.0712163262056073 0.470169830652657 no 1576 0.471612793987567 516 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1520 flindersine 88 µM 0.0710033200184154 0.470260713544765 no 1577 0.471697556584754 508 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3202 9113761 49.47 µM 0.0701427091215485 0.470627924271657 no 1578 0.47204003671535 526 4798415
SGTC_2269 7935389 174.42 µM 0.0690078708175242 0.471112182160863 no 1579 0.472491677215292 495 97605
SGTC_2624 nerol 100 µM 0.0689799928392065 0.47112407878461 no 1580 0.47250277248045 510 637566 A natural product oil.
SGTC_857 0438-0306 1.35 µM 0.0687999326673135 0.471200918122938 no 1581 0.47257443584306 514 4686136
SGTC_1387 3342-1166 1.8 µM 0.0687635797391917 0.47121643159464 no 1582 0.47258890429797 510 3418228
SGTC_2895 9054447 58.44 µM 0.0685618472843597 0.471302520933816 no 1583 0.472669194413529 514 2697450
SGTC_2451 5856223 45.7 µM 0.0675123731653718 0.471750405631326 no 1584 0.473086906069217 514 2179896
SGTC_996 3970-0799 1.8 µM 0.0672507375298355 0.471862069613858 no 1585 0.473191046903486 502 6615648 YGL040C HEM2
SGTC_727 3032-0951 202 µM 0.0659678307436424 0.472409635747933 no 1586 0.473701718496829 515 3652836
SGTC_233 rapamycin 362 pM 0.0658609810829559 0.47245524334199 no 1587 0.47374425284399 522 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1157 4092-0394 27.6 µM 0.0650248073124827 0.472812167278111 no 1588 0.474077124334959 516 3659885
SGTC_2319 6033012 152.6 µM 0.0648241778167299 0.472897809995355 no 1589 0.474156995409992 518 847246
SGTC_1836 st055642 81 µM 0.0632418952161784 0.473573282590174 no 1590 0.474786941985737 526 8571
SGTC_1294 1000-1494 117 µM 0.0621477988211385 0.474040394236441 no 1591 0.475222566291023 508 712797 YDL207W GLE1
SGTC_3041 9091929 49.47 µM 0.0619990529247029 0.474103902325795 no 1592 0.47528179310439 509 25236887
SGTC_1509 1326-1131 80 µM 0.0614680993710334 0.474330601974131 no 1593 0.475493209681402 520 768313
SGTC_1751 st044839 27.194 µM 0.061277126219799 0.474412143244797 no 1594 0.475569253597379 519 5291326
SGTC_883 0850-0245 24.6 µM 0.0611278341236336 0.474475888382494 no 1595 0.475628701084766 522 6823229 YPR165W RHO1
SGTC_623 k072-0108 16.9 µM 0.0603995056761334 0.474786881346961 no 1596 0.475918726176827 519 5382803
SGTC_3254 9136651 49.47 µM 0.0595120009371778 0.475165862618654 no 1597 0.47627215352717 531 16454030
SGTC_68 0986-0284 82.829 µM 0.0592452663937097 0.475279767709409 no 1598 0.476378377784808 524 423278 YIL048W NEO1
SGTC_3079 9117512 49.47 µM 0.0585913696695297 0.475559013283014 no 1599 0.476638792440401 524 7185044
SGTC_1210 3013-0140 750 nM 0.0584308252212285 0.475627575379517 no 1600 0.476702730866762 515 905973
SGTC_1026 k007-1105 30.6 µM 0.0573918052700713 0.476071316498243 no 1601 0.47711654534572 517 7066794
SGTC_2822 7994718 71.43 µM 0.0542918967400684 0.477395389123352 no 1602 0.478351302748878 534 1018011
SGTC_523 1934-0222 13.7 µM 0.0542703776681001 0.477404581514091 no 1603 0.478359874978426 533 1361595
SGTC_3316 9136639 10.545 µM 0.0538421016451265 0.477587532443688 no 1604 0.47853048294338 526 4903665
SGTC_176 1486-1328 72.834 µM 0.0535146041247479 0.47772743600677 no 1605 0.478660947456966 507 22310231
SGTC_1238 0333-0287 48.8 µM 0.0531740725192607 0.477872910507236 no 1606 0.478796606756872 521 7226
SGTC_2982 9019404 25.97 µM 0.0527306874455936 0.478062328243342 no 1607 0.478973243992747 484 22333232
SGTC_3023 9089636 49.47 µM 0.0527230169950759 0.478065605166377 no 1608 0.478976299809045 535 17249241
SGTC_1863 st057641 20.1 µM 0.0525076700347942 0.478157604984276 no 1609 0.47906209198164 533 3921635
SGTC_2997 9067075 71.4286 µM 0.0518471671469719 0.478439790087658 no 1610 0.479325236058592 524 27209819
SGTC_1732 st034308 51.822 µM 0.0506219333120497 0.478963272386699 no 1611 0.479813392487367 519 830119
SGTC_343 4130-2827 29.8 µM 0.0469609671854999 0.480527636240826 no 1612 0.481272168429767 513 1118244
SGTC_2473 5854593 8.94 µM 0.0457731775770608 0.481035255066723 no 1613 0.481745518794164 530 2872951
SGTC_2416 tofa 880 nM 0.0453445217388132 0.481218454846105 no 1614 0.48191635034871 514 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2564 betulinic acid 100 µM 0.0445533975594224 0.481556577448711 no 1615 0.482231644552149 509 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1188 1403-0014 4.57 µM 0.0444778235835178 0.481588878094263 no 1616 0.482261764348349 526 9614867
SGTC_3248 9135562 49.47 µM 0.0441060556959676 0.481747775059818 no 1617 0.482409932868315 511 17650701
SGTC_2730 imipramine 71.33 µM 0.0435073128400736 0.482003689269278 no 1618 0.482648567622073 535 3696 A tricyclic antidepressant.
SGTC_2088 5278280 127.392 µM 0.0420798489901308 0.482613844485776 no 1619 0.483217522058272 520 791502
SGTC_3216 9129716 49.47 µM 0.0414750030779683 0.48287239221757 no 1620 0.483458610178285 520 8056934
SGTC_2699 st077704 54.6 µM 0.0414180121983578 0.482896753940068 no 1621 0.483481326729981 523 645852
SGTC_2239 6685329 187.64 µM 0.0413816646500127 0.482912291352253 no 1622 0.483495814882522 495 805680
SGTC_1997 st073024 93.8 µM 0.0402519592414075 0.483395217033643 no 1623 0.483946126841613 537 686268
SGTC_1073 triclabendazole 3.09 µM 0.0402382756407458 0.483401066640478 no 1624 0.483951581389394 515 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_605 1315-0399 119 µM 0.0384866882471134 0.484149882357861 no 1625 0.484649822430682 524 24020461
SGTC_102 gallobenzophenone 83.616 µM 0.0366747782785549 0.484924545187385 no 1626 0.485372159564015 528 70837
SGTC_3172 9105863 49.47 µM 0.0356926853206948 0.485344452548285 no 1627 0.485763701552939 535 2348785
SGTC_574 1315-0397 40 µM 0.0356013006722452 0.485383526146101 no 1628 0.4858001355971 537 6794277
SGTC_3154 9100113 49.47 µM 0.0348160471308556 0.485719285013507 no 1629 0.486113212314515 529 25237525
SGTC_456 gingerol 170 µM 0.0329127722988224 0.486533129189532 no 1630 0.486872073746509 531 442793 A herb.
SGTC_644 1498-1197 63.3 µM 0.0321613910700412 0.486854436956869 no 1631 0.487171672851299 528 6741615
SGTC_297 0986-0032 24 µM 0.0319266390430482 0.486954824042287 no 1632 0.48726527729032 525 2847425
SGTC_699 0375-0592 111 µM 0.0319176721647276 0.486958658567801 no 1633 0.487268852735009 532 762578
SGTC_1353 1498-1206 8.11 µM 0.0310437980977673 0.487332360949336 no 1634 0.487617305329546 532 6756808
SGTC_1428 4049-0204 61.7 µM 0.0308264784743341 0.487425296973267 no 1635 0.487703961841207 531 X1428
SGTC_2460 5552655 174.22 µM 0.0303307648081652 0.487637289843443 no 1636 0.487901630542718 515 5401989
SGTC_869 0564-0080 44.1 µM 0.0291258541675329 0.488152586562533 no 1637 0.488382107949071 520 6843321
SGTC_174 3553-0389 74.3 µM 0.0290418111100766 0.488188529487578 no 1638 0.48841562210076 530 738071
SGTC_66 0109-0187 42.4 µM 0.0263073324354779 0.489358042153195 no 1639 0.489506103249431 505 759417
SGTC_393 acivicin 6.25 µM 0.0257516223744615 0.489595726010794 no 1640 0.489727724394949 533 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1090 efavirenz 20.7 µM 0.0255081923371486 0.489699845125896 no 1641 0.489824807037263 521 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_163 TUB2.036 7.546 µM 0.0253946307794136 0.489748417551813 no 1642 0.489870096872875 540 15992207 YJR013W GPI14
SGTC_1044 1222-0021 1.78 µM 0.025026533227397 0.489905860877655 no 1643 0.490016899889395 532 4306703
SGTC_454 lyso-paf C-16 6.67 µM 0.0238358491248101 0.490415153002423 no 1644 0.490491772349652 531 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1359 1582-0056 520 nM 0.0223576662110453 0.491047438839786 no 1645 0.491081324686128 529 3661189
SGTC_64 000l-0018 272.079 µM 0.0216585064686079 0.491346509088002 no 1646 0.491360181521313 536 6811119
SGTC_1278 0874-0585 172 µM 0.0216077074584603 0.49136823889538 no 1647 0.491380442652689 539 766306
SGTC_2993 9054257 71.4286 µM 0.0216045217351323 0.491369601622675 no 1648 0.491381713275805 543 6470217 YGL055W OLE1
SGTC_2809 7964133 12.99 µM 0.0210602729726228 0.491602411328893 no 1649 0.491598787717767 530 1253665
SGTC_2721 ifenprodil 61.44 µM 0.0202169569275581 0.491963156697383 no 1650 0.491935150489021 530 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2151 5563267 85.4165 µM 0.0199608154608465 0.492072727667047 no 1651 0.492037315532463 542 5310824
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.0191880305929177 0.492403309467024 no 1652 0.492345553024773 538 66535 A nucleotide analog.
SGTC_2911 7942208 15.64 µM 0.0178226942009762 0.492987385483759 no 1653 0.492890150139997 542 1243384
SGTC_1109 tnp00067 928.257 nM 0.0174009908368043 0.493167788680735 no 1654 0.493058359351169 543 676295
SGTC_2545 solidagenone 89.61 µM 0.0171856402319838 0.493259915443672 no 1655 0.4931442589669 535 6708572 An anti ulcer agent
SGTC_1400 3771-8998 51.5 µM 0.0163179396441248 0.493631120437558 no 1656 0.493490372840198 535 670767
SGTC_1291 0993-0025 5.79 µM 0.0162827570021584 0.493646171799066 no 1657 0.493504406819066 538 4353356
SGTC_2462 5162487 171.77 µM 0.0155299714780699 0.493968220441627 no 1658 0.493804686795925 544 2259986
SGTC_2703 st077852 53.4 µM 0.0145690354865179 0.49437932347251 no 1659 0.49418800136652 536 6281836
SGTC_2144 5628481 200 µM 0.014258549852391 0.494512155245625 no 1660 0.494311854346577 538 2818399
SGTC_419 nsc-638432 893 µM 0.0132923018717015 0.494925538689672 no 1661 0.494697294931642 521 368090
SGTC_2196 6573537 42.6665 µM 0.0131353333321021 0.494992694021696 no 1662 0.494759910851952 544 2903087
SGTC_946 3434-1334 87.4 µM 0.0120896652898363 0.495440062257323 no 1663 0.495177038847608 542 4047976
SGTC_137 0438-0332 85.389 µM 0.0119427298597133 0.495502926125676 no 1664 0.495235653371321 541 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1495 4469-0029 237 µM 0.011717490238469 0.495599291349928 no 1665 0.495325504691634 539 793680
SGTC_1882 5615643 20 µM 0.0116250147141468 0.495638855621125 no 1666 0.495362394575554 540 2253075
SGTC_2727 riluzole 51.77 µM 0.0112109725745319 0.49581599788389 no 1667 0.49552756272285 544 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2408 sulbentine 18.36 µM 0.0075034798569197 0.497402230542279 no 1668 0.497006572724389 541 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2302 7771753 200 µM 0.00621042121724251 0.49795547030885 no 1669 0.497522416323808 543 2203047
SGTC_2345 9052315 157.45 µM 0.00593090627527037 0.498075062330484 no 1670 0.497633924597078 545 6469265
SGTC_858 0438-0351 2.77 µM 0.00538399785089429 0.498309060630348 no 1671 0.497852105996682 544 2799119
SGTC_3140 9094243 49.47 µM 0.00505633370380333 0.498449254134705 no 1672 0.497982823297099 545 19291112
SGTC_2109 5483026 200 µM 0.00333302415953188 0.499186587488222 no 1673 0.498670318203081 547 759335
SGTC_2686 alizarin 95.37 µM 0.00329508032461508 0.499202822136799 no 1674 0.498685455519982 545 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_3049 9092223 49.47 µM 0.00328015220596412 0.49920920928176 no 1675 0.498691410945494 545 8623917
SGTC_3272 9137413 49.47 µM 0.00316455905724334 0.499258666974001 no 1676 0.4987375257004 541 17614870
SGTC_2685 mycophenolic acid 18.85 µM 0.00186118529877188 0.499816329164657 no 1677 0.499257494921333 547 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_911 3456-4043 236 µM 0.00143190825778415 0.5 no 1678 0.499428751449525 547 914281
SGTC_235 0330-0087 5 mM 0.00133424499926471 0.499958213714774 no 1679 0.499467713415309 547 46494818 YHR062C RPP1
SGTC_537 1334-0398 209 µM 0.000642591837119907 0.499662282441646 no 1680 0.499743642964775 548 5846986
SGTC_1379 2144-0755 36.5 µM 0.000630214797815136 0.499656986792953 no 1681 0.49974858068806 548 5392327
SGTC_3182 9108849 49.47 µM 0.000106539063986989 0.499432926594381 no 1682 0.499957497062942 548 17133045
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 7.57165485650403e-05 0.499419738860211 no 1683 0.49996979346748 547 4330530
SGTC_661 1304-0007 33.6 µM -6.48397638889641e-06 0.499384568512818 no 1684 0.499997413267673 549 3117130
SGTC_1581 himbacine 57.9 µM -0.00011992715155238 0.499336030681317 no 1685 0.499952155988792 549 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2168 5727979 200 µM -0.000174655028481616 0.499312614798684 no 1686 0.499930322725008 548 695210
SGTC_1932 st074806 40.9 µM -0.000202363183999458 0.499300759581474 no 1687 0.499919268770457 548 17251235
SGTC_933 2914-0560 114 µM -0.000256869393764789 0.499277438544986 no 1688 0.499897523939413 548 463887
SGTC_3261 9137475 49.47 µM -0.000289871771091281 0.499263318143218 no 1689 0.499884357896236 549 17027690
SGTC_518 1021-0119 62.6 µM -0.000378732353279685 0.499225298246763 no 1690 0.499848907654933 549 1097762
SGTC_485 niflumic acid 177 µM -0.00196067735677531 0.49854844862074 no 1691 0.499217803405317 552 4488 A COX2 inhibitor.
SGTC_220 paclitaxel 373.376 µM -0.00237765823166663 0.498370040159102 no 1692 0.499051452496775 548 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_908 3448-7491 47.7 µM -0.0037240805974477 0.497793965442203 no 1693 0.498514310228173 551 1203031
SGTC_2664 lyso-paf C-16 73.48 µM -0.0037797410346858 0.497770150887979 no 1694 0.498492105082705 551 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1741 st038134 10.228 µM -0.00429401924232821 0.497550115161811 no 1695 0.498286939435786 551 1272587
SGTC_793 0488-0545 106 µM -0.00555421528888818 0.497010939172198 no 1696 0.497784200079465 550 292548
SGTC_774 k060-0086 136 µM -0.00595524173411532 0.496839360752288 no 1697 0.497624216325082 550 5911235
SGTC_2804 7954240 19.48 µM -0.00605527679535422 0.496796561026968 no 1698 0.497584308829249 552 828705
SGTC_2928 9011484 9.79 µM -0.00645326614785155 0.496626282749105 no 1699 0.497425537155716 553 2994751
SGTC_1709 st033179 39.1045 µM -0.00651796501742375 0.496598601633439 no 1700 0.497399726583997 553 573381
SGTC_288 1315-0019 35.1 µM -0.00791575483821801 0.496000567869017 no 1701 0.496842103692306 555 6811474
SGTC_192 3455-0609 60.9 µM -0.0084877556698532 0.49575584417039 no 1702 0.496613916054335 557 3769639
SGTC_3054 9094397 49.47 µM -0.00890404551360465 0.495577740550178 no 1703 0.496447846715052 562 2598354
SGTC_245 methotrexate 289.6 µM -0.00920898850698298 0.495447275635209 no 1704 0.496326197051338 555 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_266 formosanin C 406 nM -0.00925433626823066 0.495427874372139 no 1705 0.496308106682935 552 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2949 9072542 2.23 µM -0.00939619144582566 0.495367184133711 no 1706 0.49625151711553 557 16457352
SGTC_2679 rapamycin 1 nM -0.00943698867023066 0.495349729779835 no 1707 0.496235242099379 557 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1452 4194-0072 190 µM -0.00966457210537887 0.495252362491521 no 1708 0.496144453585816 563 1343545
SGTC_1604 st002052 72.4 µM -0.00975948952703852 0.495211753942793 no 1709 0.496106588798996 555 6254834 YHR062C RPP1
SGTC_3166 9102297 49.47 µM -0.0102004780819207 0.495023086335728 no 1710 0.495930668581758 556 25237072
SGTC_304 1310-0298 97 µM -0.0105081590387942 0.494891452215984 no 1711 0.495807928219461 554 1550234
SGTC_2335 9018011 154.17 µM -0.0106199449304972 0.49484362736699 no 1712 0.495763334589308 553 6458208
SGTC_2130 NSC 7 2.4545 µM -0.0112488477739045 0.494574568128482 no 1713 0.495512453657181 552 21448
SGTC_1419 3993-2473 62.6 µM -0.0114511334537046 0.494488026136636 no 1714 0.495431758544759 550 704026
SGTC_449 xestospongin c 11.1929 µM -0.0114790306969393 0.494476091140051 no 1715 0.495420629886371 553 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_848 0368-0089 85.6 µM -0.0130475793384221 0.493805043044671 no 1716 0.494794916630412 554 762535
SGTC_2867 9039098 71.43 µM -0.0133484125748161 0.493676344122543 no 1717 0.494674911985602 562 6463460
SGTC_790 1575-0012 79.1 µM -0.0141161615083886 0.493347897856294 no 1718 0.494368653360618 565 378741 YLR208W SEC13
SGTC_2017 5132927 60.65 µM -0.0151706798956533 0.492896777791494 no 1719 0.493948006511986 560 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2477 5967686 25.23 µM -0.0151909301830531 0.492888114861315 no 1720 0.493939928746994 560 776118
SGTC_2643 anethole 100 µM -0.0156767409871585 0.492680289439268 no 1721 0.493746141360636 557 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_353 1988-1175 58.3 µM -0.0158234641710289 0.492617522990215 no 1722 0.493687614538827 553 2788357
SGTC_3184 9108758 49.47 µM -0.0162204579035435 0.492447694670458 no 1723 0.493529257281627 556 902885
SGTC_1200 1643-0193 18.4 µM -0.0166053808990734 0.492283031348571 no 1724 0.493375715907141 560 5403974
SGTC_1253 0550-0034 176 µM -0.0170701011610597 0.492084233907182 no 1725 0.493190345626726 559 5969915
SGTC_2858 9025781 8.96 µM -0.0173839344301706 0.491949983820467 no 1726 0.493065162843829 564 4894980 YPL153C RAD53
SGTC_668 1682-0499 62.6 µM -0.0174196784090866 0.491934693490606 no 1727 0.493050905218301 551 682214
SGTC_684 1140-0066 328 µM -0.017932800006526 0.491715194944578 no 1728 0.492846231297963 564 6813534
SGTC_2814 7977482 42.97 µM -0.0189799337115648 0.491267269352782 no 1729 0.492428556552763 559 6456762
SGTC_601 0986-0029 62.9 µM -0.0199236980394055 0.490863570828083 no 1730 0.492052120297042 555 24747981
SGTC_487 nimodipine 119 µM -0.0200346678279491 0.490816103715987 no 1731 0.492007858591372 563 4497 L-type voltage-gated calcium channels inhibitor
SGTC_134 0269-0018 6.916 µM -0.020306941378447 0.49069963978459 no 1732 0.491899259255263 556 4378915
SGTC_746 1095-0025 46.6 µM -0.0209458488531183 0.490426352776964 no 1733 0.491644426269566 557 6749286
SGTC_98 0074-0023 107.663 µM -0.0232484685037894 0.489441465846113 no 1734 0.490726038382691 570 3563821
SGTC_1951 sophoraflavanone G 9.2 µM -0.0237475484493313 0.489228005388197 no 1735 0.490526989253891 570 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_652 0437-0092 114 µM -0.0255825807615919 0.488443174486053 no 1736 0.489795140031018 559 3091274
SGTC_2318 6029776 164 µM -0.0268142127738092 0.487916438719112 no 1737 0.489303958570079 568 818325
SGTC_2229 7354935 190 µM -0.0270133871002098 0.487831259191645 no 1738 0.489224528283218 560 318112
SGTC_2006 4011487 200 µM -0.0272510630529147 0.487729614662656 no 1739 0.48912974419131 557 45595294
SGTC_2852 9023854 51.95 µM -0.0287753764569274 0.487077745823739 no 1740 0.488521869743336 555 19798528
SGTC_409 arachidonic acid 100 µM -0.0291567759309782 0.486914646618318 no 1741 0.488369777187102 562 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2111 5486399 200 µM -0.0310388560601309 0.486109838610494 no 1742 0.487619275967663 562 689674
SGTC_154 3389-1638 511.116 µM -0.0311826459547103 0.486048354002611 no 1743 0.487561939853191 583 5238686
SGTC_828 2074-0507 139 µM -0.0320178186510388 0.485691240477178 no 1744 0.487228920476737 558 X828
SGTC_2407 paclitaxel 400 µM -0.0333189007433432 0.485134930588181 no 1745 0.486710140756782 599 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2030 5175110 200 µM -0.0343629591666455 0.484688538408862 no 1746 0.486293860159718 569 2831986
SGTC_50 0929-0078 56.389 µM -0.0343771806140261 0.484682458092118 no 1747 0.486288189973159 565 1377751
SGTC_2511 berberine 10.47 µM -0.03539554286939 0.48424707117244 no 1748 0.485882169380808 563 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2439 5492030 7.2 µM -0.0354994219322912 0.484202660140054 no 1749 0.485840753658687 564 5722370
SGTC_2012 4023501 200 µM -0.0355180695627142 0.484194687808172 no 1750 0.48583331901902 566 3477460
SGTC_728 3030-5151 22.5 µM -0.0364494536610751 0.483796505742442 no 1751 0.485461991017663 575 3125388
SGTC_2174 5790901 200 µM -0.0366031385221332 0.483730804471763 no 1752 0.485400720515068 571 786020
SGTC_1807 st050092 58.9 µM -0.0382848549745448 0.483011889077327 no 1753 0.48473028295674 577 5008496
SGTC_1147 3809-1045 12.3 µM -0.0391846652491409 0.482627252556601 no 1754 0.484371579802731 561 325925
SGTC_3117 9124945 49.47 µM -0.0394032324148392 0.482533825383582 no 1755 0.484284451409119 561 17592065
SGTC_135 0933-0004 26.348 µM -0.0394087584149874 0.482531463291097 no 1756 0.484282248565006 565 21230617 YGL099W LSG1
SGTC_1243 0416-0003 5.65 µM -0.0399890242041451 0.482283431717429 no 1757 0.484050938355591 573 2141977
SGTC_1851 st056236 18.9 µM -0.0403817916614912 0.482115549209665 no 1758 0.483894373278434 567 5393171
SGTC_2101 5377231 179.231 µM -0.0406034971847338 0.482020785936155 no 1759 0.483805998053709 569 2844213
SGTC_1300 1094-0077 113 µM -0.0406407774245566 0.48200485139639 no 1760 0.483791137655883 560 5532636
SGTC_1197 1601-0112 267 µM -0.0410958500585438 0.481810343894726 no 1761 0.483609741492033 572 7350313
SGTC_1840 st055363 71 µM -0.0412108097616668 0.481761208411602 no 1762 0.483563918025606 584 676033
SGTC_807 1315-0151 48 µM -0.0414564489350919 0.481656219513002 no 1763 0.483466005849539 570 4011080
SGTC_185 k048-0037 25.491 µM -0.0417273470238995 0.481540436150163 no 1764 0.483358026584874 560 6827589
SGTC_2767 sibutramine 71.45 µM -0.0418049844362528 0.481507253771234 no 1765 0.483327080741487 579 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1739 st037196 92.5 µM -0.0419615997742011 0.481440316465592 no 1766 0.483264655039404 579 612214
SGTC_937 3122-0005 46.7 µM -0.0419714380686448 0.481436111601635 no 1767 0.483260733582517 559 759535
SGTC_2251 lansoprazole 556 µM -0.0422946602881016 0.481297968334844 no 1768 0.483131900975959 590 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2652 actinonin 100 µM -0.0423565673799341 0.481271509865327 no 1769 0.483107225731803 568 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_15 0266-0086 27.098 µM -0.0426810986033306 0.481132809831174 no 1770 0.482977873483714 569 1712902 YIL048W NEO1
SGTC_2587 piperic acid 92.2 µM -0.0430300419680238 0.48098367894322 no 1771 0.482838792999039 570 5370536
SGTC_3135 9127742 49.47 µM -0.0432172556020459 0.480903668958798 no 1772 0.482764174979002 565 3643468
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.0434963573008258 0.480784389959111 no 1773 0.48265293411633 565 756377
SGTC_1635 st007035 42.4 µM -0.0468571213061014 0.479348246757236 no 1774 0.481313551385892 566 3716403
SGTC_1179 1021-1431 9.29 µM -0.0472132915866744 0.479196061176159 no 1775 0.48117161709094 572 2840958
SGTC_2061 5245884 80.95 µM -0.0476165256581552 0.479023769689038 no 1776 0.481010930699022 581 573863
SGTC_1010 4112-3296 15.2 µM -0.0482256259874943 0.478763524317851 no 1777 0.480768213679712 573 704384
SGTC_1492 4158-0558 28.5 µM -0.0483661643023937 0.478703478930219 no 1778 0.480712212353392 564 3967268
SGTC_1229 0139-0193 12.2 µM -0.049714068994141 0.478127607632616 no 1779 0.480175122443599 572 3090752
SGTC_1351 1496-0003 46.5 µM -0.0503439534079966 0.477858514903871 no 1780 0.479924149200612 572 3891978
SGTC_720 r052-1644 49.9 µM -0.0521163028871504 0.477101404579533 no 1781 0.479218011396817 576 1422863 YOR257W CDC31
SGTC_1148 3909-7663 27.7 µM -0.0523654691427727 0.476994972572641 no 1782 0.47911874399116 604 4084526
SGTC_1143 3454-2408 5.08 µM -0.0524619484161904 0.476953761643179 no 1783 0.479080307162871 576 X1143
SGTC_2423 st077119 87.2 µM -0.0550370640612694 0.475853898599581 no 1784 0.478054467838662 566 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2020 4017018 200 µM -0.0557165689787236 0.475563704160785 no 1785 0.477783799934869 573 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2107 5363541 170.161 µM -0.0585638969259974 0.474347845774551 no 1786 0.47664973369167 564 244052
SGTC_1814 st052110 31.539 µM -0.059834027535961 0.473805554363652 no 1787 0.476143912030995 592 674163
SGTC_2322 7413319 38.22 µM -0.0601337854274758 0.473677577615024 no 1788 0.476024540880742 569 1840400
SGTC_2744 captopril 92.04 µM -0.0602106051107915 0.473644781139422 no 1789 0.47599394969192 576 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1415 3966-0071 78.1 µM -0.0614509790230131 0.473115255639072 no 1790 0.475500026824804 572 2893185
SGTC_1799 st045822 46.1415 µM -0.0614962007343555 0.473095951022274 no 1791 0.475482020028186 575 3674992
SGTC_3218 9131285 49.47 µM -0.0615303385918748 0.473081378014188 no 1792 0.475468426735514 591 17156417
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.0621068548997733 0.472835276146062 no 1793 0.475238869059249 574 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2375 9072683 200 µM -0.0626028915701913 0.47262353752369 no 1794 0.475041363398143 579 16798029
SGTC_2056 5235370 200 µM -0.0628742853404605 0.472507693425271 no 1795 0.47493330582264 585 5511916
SGTC_2201 6605497 169.863 µM -0.0632341225063716 0.472354100959071 no 1796 0.474790036654261 578 670741
SGTC_3206 9114350 49.47 µM -0.0635418662104209 0.47222274726429 no 1797 0.474667511083293 589 17087243
SGTC_1727 st034309 9.9045 µM -0.0646223072530589 0.471761608562422 no 1798 0.474237361605521 633 870305
SGTC_606 k015-0008 38.6 µM -0.0649085404232742 0.471639448849785 no 1799 0.474123410330781 593 1970475
SGTC_3097 9117246 49.47 µM -0.0656978588678462 0.471302594293129 no 1800 0.473809188554116 576 16423892
SGTC_2382 9035899 200 µM -0.0660131435692549 0.471168047114377 no 1801 0.473683680612826 582 6462679
SGTC_1724 st037281 8.293 µM -0.0664840657454555 0.47096708805667 no 1802 0.473496221666567 583 574124 YDL195W SEC31
SGTC_1691 st019933 84.6 µM -0.0669903112749687 0.470751063528317 no 1803 0.47329470817843 580 6176082
SGTC_1311 1190-0148 100 µM -0.0670589250208987 0.470721785407996 no 1804 0.473267396668854 580 1961333
SGTC_60 0986-0278 202 µM -0.0676829818741176 0.470455501858974 no 1805 0.473018998369632 576 3110598
SGTC_2307 7538926 6.34 µM -0.0700653541211212 0.469439071888676 no 1806 0.472070821156369 586 96582
SGTC_1947 st076332 61.6 µM -0.0705877108675286 0.469216236775325 no 1807 0.471862945660778 587 24208416
SGTC_223 busulfan 5 mM -0.0706267813498882 0.4691995698644 no 1808 0.471847397598319 577 2478 A DNA alkylator.
SGTC_148 3253-0744 288.01 µM -0.071405350726827 0.468867454556964 no 1809 0.471537575609069 571 6893655
SGTC_3349 9149703 23.001 µM -0.0716412532750449 0.468766829579228 no 1810 0.47144370451874 588 4910494
SGTC_2044 5102272 200 µM -0.07264921908605 0.46833690112969 no 1811 0.471042629500573 581 592666
SGTC_1654 st012436 41.8 µM -0.0729168555161831 0.468222752136029 no 1812 0.470936140443 587 4323132
SGTC_2286 7945697 125 µM -0.0730460833743 0.468167636396423 no 1813 0.470884723101087 593 1245733
SGTC_466 geldanamycin 89.2 µM -0.0738504801555272 0.46782457456829 no 1814 0.470564679649954 578 5288382 HSP90 inhibitor.
SGTC_1866 st057638 64 µM -0.0752572556333723 0.467224665848016 no 1815 0.470005015028269 587 688802
SGTC_285 1486-1325 46 µM -0.0754752612952149 0.467131705616445 no 1816 0.469918290004878 589 22310230
SGTC_1989 st071868 50.2 µM -0.0784568407329881 0.465860506410728 no 1817 0.468732330228232 579 16414057
SGTC_876 0720-0963 56.8 µM -0.0784853816884147 0.465848339609555 no 1818 0.468720979036948 581 765861
SGTC_598 3937-0236 20.2 µM -0.0790229103092129 0.465619201052575 no 1819 0.468507200126195 576 1379313
SGTC_3268 9137683 49.47 µM -0.0790565765625087 0.46560485012698 no 1820 0.468493811122156 583 1953228
SGTC_1248 0469-0687 58.6 µM -0.0802038203425857 0.465115840973893 no 1821 0.468037575879406 598 4017482
SGTC_3179 9107801 49.47 µM -0.0807602099560603 0.464878700525423 no 1822 0.467816326258802 580 4818259
SGTC_3146 9095609 49.47 µM -0.0812562210524791 0.46466730469572 no 1823 0.467619094675237 591 17173999
SGTC_473 2-arachidonoylglycerol 10 µM -0.0812987924491027 0.464649161582184 no 1824 0.467602167149528 572 5282280 An endocannabinoid.
SGTC_970 1315-0089 19.5 µM -0.0819054067925901 0.46439064217564 no 1825 0.467360967444741 574 6811083 YLR033W RSC58
SGTC_205 1486-1330 71.903 µM -0.0825335022390178 0.464122984059298 no 1826 0.46711123913377 586 4118834
SGTC_2354 9060492 162 µM -0.0827510315593929 0.464030289366431 no 1827 0.46702475333361 594 6471895
SGTC_1262 0737-0114 49.6 µM -0.0842348825366697 0.463398035635061 no 1828 0.466434842239371 586 765919
SGTC_309 k408-0051 1.48 µM -0.0847241200744226 0.463189596707126 no 1829 0.466240359931343 587 3640463
SGTC_935 2996-0153 430 µM -0.0847594227902731 0.463174556427583 no 1830 0.466226326663572 585 23738523
SGTC_2358 9037157 4 µM -0.085430289961366 0.462888751908399 no 1831 0.465959656636185 581 2388925
SGTC_941 3237-0776 460 µM -0.0856446972614101 0.462797413603715 no 1832 0.465874432846986 587 760008
SGTC_1846 st056244 14.8 µM -0.0861777915992594 0.462570321950971 no 1833 0.465662542377737 602 5393182
SGTC_229 benomyl 22.8748 µM -0.0867437639961853 0.462329238000709 no 1834 0.465437594430724 596 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_581 0958-0271 211 µM -0.0883080580442255 0.461662977068159 no 1835 0.464815917293021 598 4591145
SGTC_1529 apigenin 74 µM -0.0883636615948914 0.461639296486002 no 1836 0.464793821065032 610 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3186 9110464 49.47 µM -0.0894243672274293 0.46118758660088 no 1837 0.464372329399416 589 17018021
SGTC_944 3370-0224 231 µM -0.091099582822983 0.460474284996475 no 1838 0.463706732062489 591 4580514
SGTC_928 2764-0428 58.7 µM -0.0915414932936188 0.460286141993272 no 1839 0.463531168870777 586 662578
SGTC_697 0508-1955 564 µM -0.091561782897205 0.46027750392514 no 1840 0.463523108341417 581 6243113
SGTC_2976 9009005 19.48 µM -0.0915980828384048 0.460262049684503 no 1841 0.463508687360618 578 2993148
SGTC_1471 k673-0312 37 µM -0.0933030268986878 0.459536259347048 no 1842 0.462831413728813 581 24099884
SGTC_2764 methyldopa 94.69 µM -0.0939794213766386 0.459248357164203 no 1843 0.462562751869157 602 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1382 3002-2117 298 µM -0.0952593809116704 0.458703610694211 no 1844 0.462054402611325 600 1497314
SGTC_3327 9140648 26.9345 µM -0.0970662043868577 0.457934764928797 no 1845 0.461336909542749 608 8029710
SGTC_2961 9083290 32.55 µM -0.0973624446435972 0.457808722691856 no 1846 0.461219283912737 600 17741490
SGTC_1355 1499-0035 1.68 µM -0.0974146276283212 0.457786520678878 no 1847 0.461198564404532 598 1548538
SGTC_2824 7998404 51.95 µM -0.0978114720134857 0.457617681754238 no 1848 0.461040998859052 580 837851
SGTC_2426 5582046 32.21 µM -0.0991982100924115 0.457027749121017 no 1849 0.460490447994953 615 2251934
SGTC_1453 4237-0541 195 µM -0.0999180216973881 0.456721571112748 no 1850 0.460204704352379 583 739892
SGTC_1716 st033144 30.6155 µM -0.100529405555822 0.456461533942242 no 1851 0.459962019411356 595 674617
SGTC_2072 5231554 129 µM -0.100736232164767 0.456373569517867 no 1852 0.459879924273933 595 789545
SGTC_1232 0279-0259 161 µM -0.10188687837476 0.45588423289775 no 1853 0.459423232648976 595 1560000
SGTC_3252 9135871 49.47 µM -0.102648136127729 0.455560528679533 no 1854 0.459121118741033 614 17682838
SGTC_493 zm226600 134 µM -0.102916608409293 0.455446375146625 no 1855 0.459014578045481 620 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1483 3453-0561 55.9 µM -0.106071840659676 0.454105058905637 no 1856 0.457762676487533 598 4546991
SGTC_1009 4106-0057 9.87 µM -0.108521367266312 0.453064104168115 no 1857 0.456791065989324 595 2928005
SGTC_325 2810-4341 181 µM -0.108946036149359 0.452883668798402 no 1858 0.456622646181764 592 774970
SGTC_3296 9122258 64.045 µM -0.109167878361972 0.452789415271698 no 1859 0.456534668679124 609 4730474
SGTC_962 1254-0300 21.5 µM -0.10936239145385 0.452706775186226 no 1860 0.456457531028091 595 7340576
SGTC_2294 7971431 200 µM -0.10966834615833 0.452576792591592 no 1861 0.456336202530719 625 5741572
SGTC_3300 9124615 50.48 µM -0.110547779267428 0.452203200281615 no 1862 0.455987479831623 610 24824903
SGTC_1827 berberine 7.24 µM -0.110839748222063 0.452079178180384 no 1863 0.455871712503416 587 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2265 7929201 200 µM -0.110945109425511 0.452034424166022 no 1864 0.455829937114652 625 1265108
SGTC_1386 3228-0095 33.8 µM -0.113153532014053 0.451096499176161 no 1865 0.454954417531168 607 870181
SGTC_1548 st061468 90.8 µM -0.113431615091831 0.45097841553873 no 1866 0.454844188117811 596 390799
SGTC_187 1488-2104 32.728 µM -0.114181261802455 0.450660111407227 no 1867 0.454547052834631 590 2852859
SGTC_818 4072-2707 53.5 µM -0.114418837150922 0.450559242214476 no 1868 0.454452891085053 596 882871
SGTC_18 0111-0177 500 nM -0.115159749452292 0.450244687918143 no 1869 0.454159250822945 615 721752
SGTC_2210 7115885 190.385 µM -0.115232617382591 0.45021375352525 no 1870 0.454130372968625 596 2927039
SGTC_703 3875-0075 71.8 µM -0.11554452084097 0.450081345553334 no 1871 0.454006767113741 600 2850814
SGTC_2812 7970281 58.44 µM -0.116145006572648 0.449826445482269 no 1872 0.45376881003218 629 2233435
SGTC_1759 st043059 70 µM -0.116160676022759 0.449819794237118 no 1873 0.453762600853128 629 669426
SGTC_3348 9149464 3.537 µM -0.117064378887409 0.449436221450541 no 1874 0.453404518567087 595 1951442
SGTC_578 3460-0051 92 µM -0.118794157501177 0.448702156430889 no 1875 0.45271921877302 611 2876744
SGTC_1466 k213-0079 57.5 µM -0.119420141627224 0.448436551091667 no 1876 0.452471252384409 608 3657981
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.119610908187464 0.448355613345751 no 1877 0.452395689140913 605 688761
SGTC_2285 7945142 200 µM -0.119664241150622 0.44833298581348 no 1878 0.452374564092229 607 2970608
SGTC_1996 st072960 66.8 µM -0.119709488051882 0.448313789079811 no 1879 0.452356642017444 600 1719405
SGTC_160 3453-0671 289.699 µM -0.119989482889259 0.448194999410251 no 1880 0.452245739601495 627 5322268
SGTC_2256 7954252 200 µM -0.122820500939299 0.446994183918363 no 1881 0.451124619883944 626 2972920
SGTC_1769 st044406 64.4 µM -0.122908807816741 0.446956735089881 no 1882 0.451089655442139 606 670903
SGTC_1196 1588-0294 184 µM -0.122993809724536 0.446920688266489 no 1883 0.451055999936578 615 6144269
SGTC_439 amiodarone 34.4 µM -0.124815805352876 0.446148139121066 no 1884 0.450334687191912 615 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2763 lisinopril 49.32 µM -0.12492750959327 0.446100781732657 no 1885 0.450290469734793 630 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_806 3966-4455 5.86 µM -0.12556017592103 0.445832575243853 no 1886 0.450040044203733 647 714982
SGTC_1164 k060-0068 93.7 µM -0.125780639639149 0.445739119788824 no 1887 0.449952783688105 592 5963676
SGTC_1805 st050013 60.3 µM -0.126923945330875 0.445254516387551 no 1888 0.449500297138912 605 4037144
SGTC_2791 5663188 71.43 µM -0.12739586171621 0.445054512951923 no 1889 0.449313545713388 614 54690634
SGTC_381 3461-2219 42.7 µM -0.127461606045175 0.44502665087968 no 1890 0.449287529606514 635 2883159
SGTC_1919 st067113 52.3 µM -0.129123329791505 0.444322512362999 no 1891 0.448630031016911 605 1268243
SGTC_3210 9128157 49.47 µM -0.12917886614997 0.444298982418356 no 1892 0.448608059226481 646 17590849
SGTC_294 k038-0071 157 µM -0.129574004211017 0.444131573860382 no 1893 0.448451735730097 602 24152826
SGTC_1980 st071811 45.7 µM -0.129626707825147 0.444109245617502 no 1894 0.44843088586719 629 4974850
SGTC_2716 st080858 38.6235 µM -0.130000710619305 0.443950801902283 no 1895 0.448282932234815 591 5296050
SGTC_1011 4112-3381 17.4 µM -0.130075625631115 0.443919065748137 no 1896 0.448253297095415 648 2877139
SGTC_1308 1187-1617 41.4 µM -0.130097263692723 0.443909899309688 no 1897 0.448244737489932 604 2882570
SGTC_1899 st063254 59.6 µM -0.131088759710375 0.443489908407422 no 1898 0.447852546441057 602 3093813
SGTC_1775 st081588 35.1725 µM -0.131360593652739 0.44337477248307 no 1899 0.447745030096357 606 1426443 YGL099W LSG1
SGTC_3311 9131146 2.8755 µM -0.132335860888458 0.442961735094076 no 1900 0.447359321955501 616 4900406 YPR165W RHO1
SGTC_2988 9073640 71.4286 µM -0.135833470353596 0.441480968289748 no 1901 0.445976465379053 625 9102229
SGTC_2119 5528445 120.635 µM -0.1370410955487 0.440969890398196 no 1902 0.445499155986432 617 791935
SGTC_755 1995-0008 37.3 µM -0.139956588772277 0.43973643406548 no 1903 0.444347144927286 600 689533
SGTC_1834 st055981 52.8 µM -0.140504313376591 0.439504773362454 no 1904 0.444130772358225 627 471719 YDL150W RPC53
SGTC_724 3910-0327 137 µM -0.140510706918556 0.439502069329249 no 1905 0.44412824675812 618 2885483
SGTC_2455 5377712 9.75 µM -0.140547188637815 0.439486640098394 no 1906 0.444113835660655 597 2243908
SGTC_1713 st033146 12.748 µM -0.141580634605536 0.439049602576364 no 1907 0.443705632086396 648 674619
SGTC_214 4373-3496 70 µM -0.141679641272905 0.439007737197251 no 1908 0.443666528307338 619 3779166
SGTC_1909 st060837 51.5 µM -0.143300442386812 0.438322472085179 no 1909 0.443026453232248 636 678937
SGTC_867 0518-0118 155 µM -0.144694534381028 0.437733206066147 no 1910 0.442476027338253 625 6848158
SGTC_2483 5729050 27.16 µM -0.145194037979056 0.437522105395465 no 1911 0.442278836528993 629 2865180
SGTC_626 0214-0009 33 µM -0.146725156263977 0.4368751338281 no 1912 0.441674480835097 637 3437874
SGTC_2692 st077426 47.7 µM -0.148590223429561 0.436087280890809 no 1913 0.440938493969082 628 25238571
SGTC_3145 9085516 49.47 µM -0.149959002866359 0.435509233943833 no 1914 0.440398480201328 602 25236195
SGTC_2305 7443522 69.23 µM -0.152067002607973 0.434619277988594 no 1915 0.439567044797371 620 5415886
SGTC_982 1491-0518 27.5 µM -0.152483931097913 0.434443298082338 no 1916 0.439402631679645 611 3091256
SGTC_839 0122-0028 230 µM -0.152964015285932 0.434240677097154 no 1917 0.439213326459922 617 759448
SGTC_2897 9048598 12.99 µM -0.15314147134276 0.434165785601007 no 1918 0.439143356087209 615 6467404
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.153942104946193 0.433827924897886 no 1919 0.438827692414837 607 279621
SGTC_1194 1488-0194 225 µM -0.154224373038809 0.433708821629968 no 1920 0.438716412593326 618 1391452
SGTC_283 0987-0079 11.7 µM -0.155581115930432 0.433136426965847 no 1921 0.438181605485655 613 411556
SGTC_969 1313-0238 134 µM -0.15633885677936 0.432816805526576 no 1922 0.437882964801947 616 5212874
SGTC_1296 1068-0102 11.9 µM -0.157837862728304 0.432184641919083 no 1923 0.437292281228208 640 767053
SGTC_822 1487-0950 154 µM -0.158419489166699 0.431939403977283 no 1924 0.437063128779443 620 1958375
SGTC_3040 9091894 49.47 µM -0.158558147222689 0.431880943830923 no 1925 0.437008502614099 610 25236966
SGTC_2835 9006588 71.43 µM -0.158752659544056 0.431798937271226 no 1926 0.436931873950381 618 2345538
SGTC_2393 9031399 185.94 µM -0.15929401334162 0.431570717533872 no 1927 0.436718618599343 642 1526623 YDL150W RPC53
SGTC_2533 agelasine 13.65 µM -0.159403659704794 0.431524496449077 no 1928 0.436675427875464 618 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_3058 9093861 49.47 µM -0.160347330898849 0.431126733602743 no 1929 0.436303738260459 638 17217477
SGTC_2347 9049783 174.81 µM -0.161042574704591 0.430833728992419 no 1930 0.43602993423993 656 6467988 YPL169C MEX67
SGTC_310 1273-0058 1.06 µM -0.161659411478309 0.430573800226186 no 1931 0.435787034486596 615 2734232
SGTC_1839 st053978 48 µM -0.162690336596432 0.430139446020205 no 1932 0.435381127949122 610 3788398
SGTC_1398 3558-0053 112 µM -0.165963906756279 0.428760772884994 no 1933 0.434092677218987 633 4532369
SGTC_2543 pimpinellin 60.67 µM -0.166436677359783 0.428561735638374 no 1934 0.43390665605018 624 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1676 st018489 23.4 µM -0.166508207349634 0.428531622969374 no 1935 0.433878512400801 605 3696235
SGTC_3152 9099253 49.47 µM -0.16724069194877 0.428223285846597 no 1936 0.433590333860491 627 25236131
SGTC_871 0574-0004 149 µM -0.167639478672437 0.428055436219542 no 1937 0.433433455596483 623 9551173
SGTC_2337 9009472 200 µM -0.168764355775437 0.427582044854334 no 1938 0.432990998041024 628 5742383
SGTC_1929 genistein trimethyl ether 50.5 µM -0.169265597765846 0.427371136560304 no 1939 0.432793867249522 617 136420
SGTC_3203 9113543 49.47 µM -0.170143323778104 0.427001864587112 no 1940 0.432448711376928 621 17018012
SGTC_921 1561-0023 372 µM -0.170980803337306 0.426649584499718 no 1941 0.432119430015849 615 24050882
SGTC_1107 amlodipine 47 µM -0.171840978418974 0.426287818600494 no 1942 0.431781274281467 636 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2475 5812728 15.03 µM -0.173133773822099 0.42574422127028 no 1943 0.431273139066286 628 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_156 3474-0145 5.642 µM -0.173425164450107 0.425621716174574 no 1944 0.431158623208718 609 2265471
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.173447367256311 0.42561238206803 no 1945 0.431149897793258 625 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_632 0781-2353 4.65 µM -0.174374890376705 0.425222486700551 no 1946 0.430785423284753 628 6811515 YHR007C ERG11
SGTC_927 2425-1185 123 µM -0.174609469958009 0.425123889956157 no 1947 0.430693253478097 638 730375
SGTC_180 1486-1293 102.781 µM -0.175225892397785 0.424864822200274 no 1948 0.43045106993985 656 4140536
SGTC_2883 9059145 45.46 µM -0.175377647953881 0.424801047906477 no 1949 0.430391451366834 614 16476510
SGTC_1984 st072354 53.1 µM -0.175515589956659 0.424743080376978 no 1950 0.430337260952524 629 5762938
SGTC_2249 haloperidol 116.36 µM -0.176548405390033 0.424309110930548 no 1951 0.429931561924552 636 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_23 0213-0011 39.996 µM -0.176609086210834 0.424283616849673 no 1952 0.429907728258504 640 627608
SGTC_227 fluconazole 33.516 µM -0.176785435844565 0.42420952815697 no 1953 0.429838464688386 637 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_3161 9100388 49.47 µM -0.177106373012579 0.424074701662161 no 1954 0.429712418060411 620 25236368
SGTC_1611 st001856 99.4 µM -0.177401803631783 0.423950598385549 no 1955 0.429596395347204 656 647478
SGTC_2385 9074692 200 µM -0.177501780410589 0.423908602259762 no 1956 0.429557133436947 610 17046906
SGTC_2914 7968218 45.32 µM -0.177851877001522 0.423761547919962 no 1957 0.429419652395856 642 2977111
SGTC_3046 9092212 49.47 µM -0.179130420497547 0.423224599688105 no 1958 0.428917648103054 605 25236637
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.179715186806319 0.422979063603894 no 1959 0.428688085108708 663 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.180726711862208 0.422554407523258 no 1960 0.428291045495304 623 1241132 A phosphatase inhibitor.
SGTC_116 0155-0182 31.788 µM -0.18099888405281 0.422440160176211 no 1961 0.428184225972496 631 771486
SGTC_1337 1486-1011 40.3 µM -0.18119094939213 0.422359542509767 no 1962 0.4281088491824 620 X1337
SGTC_3292 9120825 59.784 µM -0.181330198360048 0.422301096064948 no 1963 0.428054202022998 628 24824900
SGTC_1310 1188-0297 994 nM -0.182718948684285 0.421718294942823 no 1964 0.427509273578882 630 1588352
SGTC_2415 st077333 57.7 µM -0.18293440058905 0.421627894009683 no 1965 0.427424745280251 600 2766255
SGTC_401 neomycin 50 µM -0.18365909939679 0.421323849763069 no 1966 0.427140448490364 625 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1701 st028638 40.4 µM -0.183818795091947 0.42125685642657 no 1967 0.427077805514094 631 3490878
SGTC_3255 9139072 49.47 µM -0.18394796594518 0.421202670118517 no 1968 0.427027137699467 624 17646060
SGTC_765 1319-0117 244 µM -0.184843469894869 0.420827053300257 no 1969 0.426675905628368 608 3487746 YGL099W LSG1
SGTC_489 paxilline 115 µM -0.186199246861045 0.420258513402738 no 1970 0.426144257274732 673 105008 A toxic potassium channel blocker.
SGTC_1913 st060213 96.1 µM -0.186436291612272 0.420159126641322 no 1971 0.426051317355369 666 688959
SGTC_819 1013-0258 27.7 µM -0.186988903257067 0.419927450583976 no 1972 0.42583466670665 660 5753198
SGTC_1642 st009582 77.7 µM -0.1870151259428 0.419916457714388 no 1973 0.425824386693967 656 6739311
SGTC_2984 9022109 38.96 µM -0.188222259957703 0.419410480195186 no 1974 0.425351211708798 637 6459207
SGTC_3213 9129884 49.47 µM -0.189412211762272 0.418911835090897 no 1975 0.424884877053619 654 17190742
SGTC_2362 9071156 126 µM -0.189573689182737 0.418844178566065 no 1976 0.424821603148792 652 653133
SGTC_1348 1493-0373 93.8 µM -0.190359417937999 0.418515004741604 no 1977 0.424513747982198 664 3010129
SGTC_2188 6126565 140.678 µM -0.190465780792768 0.418470449382659 no 1978 0.42447207765098 658 874518
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.190518779724494 0.418448248540976 no 1979 0.424451314297737 648 23847180
SGTC_2193 5925765 200 µM -0.190715514596679 0.418365840100511 no 1980 0.424374241452809 637 877370
SGTC_1464 k208-0027 110 µM -0.190792144855804 0.41833374213358 no 1981 0.424344221568233 616 X1464
SGTC_1330 1469-0054 61.8 µM -0.191536453562444 0.418022003325495 no 1982 0.424052661681811 653 7102664
SGTC_1787 fluconazole 80 µM -0.191714276627049 0.417947533307217 no 1983 0.423983011148159 637 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2110 5483698 200 µM -0.192809392583443 0.41748897773901 no 1984 0.423554123648901 625 2848765 YHR062C RPP1
SGTC_737 1950-0117 57.9 µM -0.193088157622063 0.417372268937841 no 1985 0.423444963493407 633 5393513
SGTC_271 rotenone 740 µM -0.193834289902087 0.417059926282987 no 1986 0.423152818355775 631 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2027 5150920 200 µM -0.194252260413007 0.416884980142246 no 1987 0.422989182110875 645 786715
SGTC_383 2324-0395 7.37 µM -0.194271740075037 0.416876827117215 no 1988 0.422981556110178 651 3146421
SGTC_688 0527-0193 473 µM -0.196217949733845 0.416062440580573 no 1989 0.422219789642736 630 4007154
SGTC_3339 9145883 14.936 µM -0.19685487596907 0.415795998475132 no 1990 0.421970553199198 646 2030670
SGTC_3291 9121177 71.43 µM -0.197402783490185 0.415566826076941 no 1991 0.421756175784311 647 17015612
SGTC_1332 1480-0653 17.5 µM -0.199511001966891 0.414685293409411 no 1992 0.420931519012373 640 5749438
SGTC_372 0155-0182 15.9 µM -0.201244594677998 0.413960728715386 no 1993 0.42025366159884 635 771486
SGTC_3226 9131256 49.47 µM -0.203006548652758 0.413224610279565 no 1994 0.419564956852338 619 17178073
SGTC_2748 diazoxide 86.69 µM -0.203054671027646 0.413204509726129 no 1995 0.419546150438077 622 3019 A potassium channel activatior.
SGTC_1683 st010134 710 nM -0.204645013570914 0.412540357322963 no 1996 0.418924741926231 683 3818134
SGTC_2900 5328528 85.29 µM -0.20476237953069 0.412491353322609 no 1997 0.418878890487417 621 795359
SGTC_2750 bromebric acid 70.15 µM -0.20583964207757 0.412041625949818 no 1998 0.418458087150416 661 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_550 4123-0385 25.7 µM -0.207507305571406 0.411345650461497 no 1999 0.417806843909921 669 5731123
SGTC_1372 2752-0194 270 µM -0.207863895714926 0.411196868788997 no 2000 0.417667620226596 650 823334
SGTC_3072 9116419 49.47 µM -0.210408406101106 0.410135583483926 no 2001 0.4166744661926 648 17170162
SGTC_3018 9082602 49.47 µM -0.211912211082553 0.409508672921506 no 2002 0.416087761937608 642 17332089
SGTC_2231 micatex 6.853 µM -0.212523224084364 0.409254018053349 no 2003 0.415849430688112 646 20737 An antifungal of unknown mechanism.
SGTC_2706 st078239 82.5 µM -0.21349311049452 0.408849872433506 no 2004 0.415471181142483 621 15434492
SGTC_1133 3473-0247 50 µM -0.213516692063668 0.408840047345514 no 2005 0.415461985453974 634 711311
SGTC_588 3970-1144 52.9 µM -0.214230750424133 0.408542567318156 no 2006 0.415183558662228 641 1888707
SGTC_1505 k297-0037 20.6 µM -0.214366778370317 0.408485903413904 no 2007 0.415130523250454 632 4089396
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.215372293380396 0.40806710473653 no 2008 0.414738534906332 639 688801
SGTC_634 1611-4317 11.2 µM -0.215441614515402 0.408038236231957 no 2009 0.414711513990492 649 2843522
SGTC_2920 7982904 15.77 µM -0.215649967081483 0.407951471659343 no 2010 0.414630301980292 667 6456808
SGTC_2191 5911152 200 µM -0.216254115467875 0.407699910772229 no 2011 0.414394836658088 641 2875902
SGTC_1130 3454-2858 15.9 µM -0.216935620063518 0.407416185268535 no 2012 0.414129258872762 653 715628 YIL048W NEO1
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.217751676954947 0.407076506558373 no 2013 0.413811298620524 656 229346 A bile salt which induces apoptosis.
SGTC_1435 4092-0789 56.7 µM -0.218222498440946 0.406880561754767 no 2014 0.4136278781291 639 2248285
SGTC_279 1273-0055 2.93 µM -0.220047712937778 0.406121171247742 no 2015 0.41291699785199 645 2847562
SGTC_549 1661-1316 519 µM -0.220247596389007 0.406038030038289 no 2016 0.41283916501409 668 2857282
SGTC_741 4582-0002 126 µM -0.220367424556588 0.40598818973039 no 2017 0.412792506634106 618 2912688
SGTC_1547 harmine 94.2 µM -0.220575223009273 0.405901763423499 no 2018 0.412711597534676 614 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1693 xanthone 101.9 µM -0.221662052252642 0.405449810624624 no 2019 0.412288486567244 660 7020 An insecticide.
SGTC_2551 apiole 73.87 µM -0.222638379747263 0.405043916897168 no 2020 0.41190848166712 632 10659 A possible DNA adduct former.
SGTC_1946 st076057 65.1 µM -0.227646334534232 0.402963548131744 no 2021 0.409960597891721 647 953009
SGTC_2417 cerulenin 830 nM -0.228020015383446 0.402808425596967 no 2022 0.409815340167629 671 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2105 5350118 200 µM -0.229047286384586 0.402382063375527 no 2023 0.409416081833267 649 2133313
SGTC_2234 tolnaftate 200 µM -0.229497351590791 0.402195303252223 no 2024 0.409241189414389 650 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1476 4112-3294 3.34 µM -0.231068705771876 0.401543425711565 no 2025 0.408630713222531 647 704369
SGTC_1768 st044301 37.178 µM -0.231497147710223 0.401365733675164 no 2026 0.408464300531692 663 3931349
SGTC_3246 9135460 32.98 µM -0.231611687989794 0.401318232686174 no 2027 0.408419814320076 640 41446951
SGTC_427 1354-0053 47.3 µM -0.23234166143287 0.401015539758277 no 2028 0.408136328243001 683 6813657
SGTC_2595 hexamethylquercetagetin 100 µM -0.232976484934759 0.400752350275221 no 2029 0.407889832841233 687 386331
SGTC_1177 0983-0204 23.6 µM -0.233655671194159 0.400470818454993 no 2030 0.407626152205767 630 766818
SGTC_2761 levamisole 97.89 µM -0.233675070015089 0.400462778142103 no 2031 0.407618621611177 668 26879 An alkaline phosphatase inhibitor.
SGTC_2131 toluylene red 5.2905 µM -0.23377567472833 0.400421080749827 no 2032 0.407579567552768 639 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1030 k029-0042 36.7 µM -0.233878603770949 0.400378421172909 no 2033 0.407539612156243 648 6080581
SGTC_3119 9125183 49.47 µM -0.234303900290661 0.400202167011355 no 2034 0.407374529099472 656 22695334
SGTC_1043 0916-0009 19.3 µM -0.235356525003465 0.399766018878449 no 2035 0.40696601319013 694 3101130
SGTC_2090 5301565 104.445 µM -0.235929774290147 0.399528549353007 no 2036 0.406743581891378 662 2056344
SGTC_1462 k081-0014 26.5 µM -0.237764082116598 0.39876893423756 no 2037 0.406032039081789 677 3270634
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.238325374860161 0.398536570724401 no 2038 0.405814370986925 651 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_961 1252-1571 372 µM -0.238750255742655 0.398360702794433 no 2039 0.405649622470523 677 6813498
SGTC_1001 4048-4355 44.4 µM -0.238933585487882 0.39828482478632 no 2040 0.405578541109432 679 21824233
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.239149861903237 0.398195315486951 no 2041 0.405494689533528 702 688798
SGTC_1920 st075728 45.7 µM -0.239664368425858 0.397982400638751 no 2042 0.405295229914334 649 3400306
SGTC_2975 9084847 53.72 µM -0.241469454741035 0.397235654285033 no 2043 0.404595643860067 639 27211724
SGTC_1591 genipin 88.4 µM -0.241480557597674 0.397231062305445 no 2044 0.404591341736267 644 442424 A DNA cross-linking agent.
SGTC_1879 gemcitabine 100 µM -0.243034445613177 0.396588537668446 no 2045 0.403989356759305 653 60750 A nucleoside analog which inhibits DNA replication.
SGTC_960 1222-0186 7.7 µM -0.243554299843441 0.39637364321688 no 2046 0.403788012973099 673 3126296
SGTC_812 4251-0442 148 µM -0.243922623976635 0.396221406482671 no 2047 0.403645373455758 681 5723007
SGTC_1274 0865-0114 173 µM -0.244004646824121 0.39618750672936 no 2048 0.40361361051659 640 870624
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.244212038550178 0.396101795963235 no 2049 0.403533301939769 674 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_338 4055-0136 114 µM -0.245164210715094 0.395708347170103 no 2050 0.403164643286856 642 2900563
SGTC_317 4495-0002 170 µM -0.245605285069895 0.395526126017779 no 2051 0.402993898820824 665 15991618
SGTC_2576 guaiol 23.12 µM -0.245984593806168 0.395369440372212 no 2052 0.402847079258435 650 227829
SGTC_3082 9117008 49.47 µM -0.24607642827241 0.395331507741092 no 2053 0.402811534822269 640 41448529
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.24656849547745 0.39512827411445 no 2054 0.402621094403652 688 6708760
SGTC_763 3453-1109 128 µM -0.248733191143665 0.394234550851798 no 2055 0.401783586354898 655 1560353
SGTC_1252 0493-0875 34.8 µM -0.24876187005132 0.394222714110567 no 2056 0.401772493671613 647 3960963
SGTC_1420 4'-methoxyflavone 42 µM -0.249259415592608 0.39401737603752 no 2057 0.401580061179926 662 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2695 st077686 51.995 µM -0.250880007268552 0.393348759020519 no 2058 0.400953441035031 656 2876092
SGTC_2673 kobusone 100 µM -0.250967483215947 0.393312677481926 no 2059 0.400919624699949 646 6710676 An epoxy ketone and protein crosslinker.
SGTC_1627 st003713 25.6 µM -0.252076987813988 0.3928551154915 no 2060 0.40049077839643 646 16195070 YER133W GLC7
SGTC_1481 3346-2004 36 µM -0.253519297192484 0.392260525472746 no 2061 0.399933475563286 672 2770522
SGTC_2733 amorolfine 100 µM -0.254016557695156 0.392055588747793 no 2062 0.399741383180687 665 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1277 0873-0036 22 µM -0.254119457606229 0.392013184188545 no 2063 0.399701635838774 656 5965735
SGTC_2438 5259590 200 µM -0.255598336223906 0.391403887324574 no 2064 0.399130501619691 670 1201127
SGTC_2775 cyproheptadine 69.59 µM -0.257036496459305 0.390811621831319 no 2065 0.398575299604564 665 2913 A selective serotonin reuptake inhibitor.
SGTC_79 0052-0007 94.094 µM -0.257100394486831 0.390785313106075 no 2066 0.398550636512775 658 2801472
SGTC_2818 7996756 12.99 µM -0.258133920222372 0.390359849225073 no 2067 0.398151776940595 636 2241621
SGTC_2728 chlorpromazine 9.18 µM -0.259485375401645 0.389803703805218 no 2068 0.397630382217726 660 2726 A thorazine and dopamine antagonist.
SGTC_2284 7945075 39.21 µM -0.261925272597418 0.388800218932897 no 2069 0.396689527452161 673 1245402
SGTC_1767 st044992 70.3 µM -0.26288031066447 0.388407630877508 no 2070 0.396321416269493 669 9600693
SGTC_339 3091-4833 71.4 µM -0.263131145274549 0.388304539030512 no 2071 0.396224749542745 656 3240077
SGTC_1952 st077036 64.1 µM -0.263412837948049 0.388188774045085 no 2072 0.396116198330996 679 2937007
SGTC_512 prima-1 270 µM -0.263950802453291 0.387967718682862 no 2073 0.395908914299201 664 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2250 alverine citrate 130 µM -0.264256559932372 0.38784209584166 no 2074 0.395791115471254 650 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_159 3970-0959 50 µM -0.26492585340723 0.387567152390735 no 2075 0.395533290786634 659 6615653
SGTC_3313 9133968 57.047 µM -0.265191591606117 0.387458003682434 no 2076 0.395430936006964 681 1494643
SGTC_2025 5147754 141 µM -0.266415315696262 0.386955488929047 no 2077 0.394959685557781 671 315777 YLR208W SEC13
SGTC_1488 4013-0813 75.9 µM -0.266929298431016 0.386744481529207 no 2078 0.394761798971146 659 2910057
SGTC_1173 0443-0020 122 µM -0.26708409171602 0.386680940175268 no 2079 0.394702207899399 677 5331295
SGTC_2723 salbutamol 83.58 µM -0.26799171916393 0.386308427847177 no 2080 0.394352846412843 686 9884233 β2-adrenoceptor agonist
SGTC_1193 1488-0126 41.5 µM -0.268928701716419 0.385923977375767 no 2081 0.393992274776075 648 1384710
SGTC_919 tnp00227 403.569 nM -0.26997971553244 0.385492872380295 no 2082 0.393587929500602 692 1269246 A methoxyflavone. YNL221C POP1
SGTC_3267 9137951 49.47 µM -0.271358061922043 0.384927716499105 no 2083 0.393057827012821 655 16643986
SGTC_1802 st050112 57.9 µM -0.271605192575735 0.384826412662145 no 2084 0.392962803203317 651 4662563
SGTC_1460 k062-0059 9.15 µM -0.271830994149344 0.384733858918541 no 2085 0.392875986179928 633 1373085
SGTC_323 4013-0906 34.3 µM -0.272593381216053 0.384421412856012 no 2086 0.392582900175889 675 2910086
SGTC_1690 st023502 41.2 µM -0.272594261055033 0.384421052318431 no 2087 0.392582561972761 648 24207482
SGTC_1369 1866-0067 208 µM -0.273287214708053 0.384137127076896 no 2088 0.392316221292208 671 3531355
SGTC_1111 tnp00062 510.699 nM -0.273453243393236 0.384069109048275 no 2089 0.392252414707067 657 676306
SGTC_2979 9012552 45.46 µM -0.274607417825593 0.383596369851758 no 2090 0.391808933381189 674 17100905
SGTC_3022 9087993 49.47 µM -0.27507352921059 0.383405503992211 no 2091 0.391629874007998 646 17173644
SGTC_1906 st060206 94.7 µM -0.275623986341514 0.383180136210548 no 2092 0.391418442297177 686 5133468
SGTC_27 0485-0001 32.618 µM -0.27784060080185 0.382273012261674 no 2093 0.390567361396421 656 2054479
SGTC_3076 9116187 49.47 µM -0.278161293997248 0.382141825618118 no 2094 0.390444272837446 688 27241210
SGTC_333 3486-0131 40.1 µM -0.280017383477414 0.381382817362089 no 2095 0.389732084049116 653 6744690
SGTC_2279 7948423 32.93 µM -0.280018943677569 0.381382179542872 no 2096 0.389731485549564 651 1247112
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.280218050931747 0.381300785943077 no 2097 0.389655109288849 654 5355888
SGTC_5 0352-0601 109.883 µM -0.281411424570648 0.380813053614309 no 2098 0.389197428250153 685 762456
SGTC_3198 9112019 49.47 µM -0.28159458742446 0.380738211616588 no 2099 0.389127195469497 710 45595555
SGTC_2208 7283366 200 µM -0.2817424777079 0.380677785566061 no 2100 0.389070490403418 662 898663
SGTC_248 streptozotocin 5.23457 mM -0.281944768136579 0.380595137036032 no 2101 0.388992930701907 685 5300 DNA alkylating agent.
SGTC_989 1501-0895 10.3 µM -0.284690895514236 0.379473709588709 no 2102 0.387940483233818 677 2830112
SGTC_516 3992-2719 87.3 µM -0.28575278179237 0.379040341533375 no 2103 0.38753373769086 663 5350887 YDR037W KRS1
SGTC_3086 9117350 49.47 µM -0.285957831653148 0.378956675808885 no 2104 0.387455209474062 655 2679265
SGTC_2847 9005661 71.43 µM -0.286335730923922 0.378802497847733 no 2105 0.387310496954344 645 2991449
SGTC_642 0335-0876 158 µM -0.287241103293782 0.378433196247005 no 2106 0.386963857932766 651 6812350
SGTC_2832 7992762 51.95 µM -0.287843850717126 0.378187396962068 no 2107 0.386733134586612 647 2985177
SGTC_2084 5306078 60.6385 µM -0.288540239441489 0.377903472306357 no 2108 0.386466616492333 693 679340
SGTC_2014 4013930 200 µM -0.289306557539756 0.377591112954389 no 2109 0.386173397297458 705 64556
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.289612438079751 0.377466455154258 no 2110 0.386056375210273 705 689007
SGTC_377 3970-0964 33.1 µM -0.289731660709319 0.377417870914571 no 2111 0.386010766482345 655 16481235
SGTC_3243 9134147 49.47 µM -0.289896262416446 0.377350797501295 no 2112 0.385947800535174 689 24282180
SGTC_1672 st016598 6.51 µM -0.290111006180631 0.37726329730458 no 2113 0.385865658003133 702 4665860 YNL267W PIK1
SGTC_2585 alliin 100 µM -0.290924781492677 0.376931770969295 no 2114 0.385554423886156 707 87310 A garlic compound which reacts with lipids.
SGTC_580 1123-0028 41 µM -0.292270784354901 0.376383618087188 no 2115 0.385039797383037 681 1677248 YPR107C YTH1
SGTC_1660 st012960 28.1 µM -0.293204403959174 0.376003552517089 no 2116 0.384682959038286 709 24207266
SGTC_1203 3992-3522 103 µM -0.293795658851714 0.375762921759142 no 2117 0.384457026255451 746 5322312
SGTC_3075 9116269 49.47 µM -0.294523555837707 0.375466746330747 no 2118 0.38417893312902 701 17015205 YNL244C SUI1
SGTC_2970 9090938 41.86 µM -0.294590270807459 0.375439604214758 no 2119 0.384153447647424 667 17217104
SGTC_3039 9090270 49.47 µM -0.295224032457976 0.375181797312128 no 2120 0.383911372240696 654 17173750
SGTC_1962 st076595 64.5 µM -0.296925976951901 0.37448974215503 no 2121 0.383261511659891 682 279619
SGTC_1600 coumarin 106 71.1 µM -0.297217472713671 0.374371252826768 no 2122 0.383150241499122 716 100336 A hepatotoxic, DNA x-linker.
SGTC_2283 7944793 200 µM -0.297637575188021 0.374200507374924 no 2123 0.382989896367913 649 2970533
SGTC_2037 5169046 200 µM -0.298033703241927 0.374039528630581 no 2124 0.382838720181469 683 5718022
SGTC_2487 5918373 44.05 µM -0.298078938622058 0.374021147247798 no 2125 0.3828214579285 677 2876279
SGTC_2032 5185112 25.99 µM -0.299747455525137 0.373343346386347 no 2126 0.382184898844354 664 5718189
SGTC_289 k017-0060 526 µM -0.300956659219683 0.372852376787953 no 2127 0.381723772048485 679 5512909
SGTC_673 1082-0474 110 µM -0.300978828183901 0.372843377510246 no 2128 0.381715319533926 703 3098046
SGTC_2840 9008771 71.43 µM -0.30190125096446 0.372468990428775 no 2129 0.381363671049963 645 2992978
SGTC_1331 1472-0049 76.2 µM -0.302200162180058 0.372347696077859 no 2130 0.381249740307647 665 24051409
SGTC_780 0109-0199 192 µM -0.302486827838522 0.372231382711647 no 2131 0.381140486656581 698 610414
SGTC_33 0986-0033 35.816 µM -0.303866011301448 0.371671948018702 no 2132 0.380614986581269 671 2848082
SGTC_1440 4100-1550 40 µM -0.304581729346316 0.371381739812398 no 2133 0.38034236854986 692 742806
SGTC_1373 2887-0003 58.5 µM -0.305325429070631 0.371080263085327 no 2134 0.380059155211292 671 776948
SGTC_463 ikarugamyin 104 µM -0.305402750733885 0.371048923409666 no 2135 0.380029713511836 691 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_801 0866-0028 10.1 µM -0.305663138282481 0.370943390566966 no 2136 0.37993057109534 661 6849771
SGTC_1409 3909-8004 61.9 µM -0.305908163778161 0.370844092696639 no 2137 0.379837284977942 660 2119279
SGTC_3354 9151612 71.43 µM -0.307884263239505 0.370043582914461 no 2138 0.379085200324855 700 27261949
SGTC_1789 tunicamycin 25 nM -0.308577580303182 0.369762856178019 no 2139 0.378821438711367 703 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3085 9117376 49.47 µM -0.308794758853141 0.369674934017487 no 2140 0.378738828135004 679 16480349
SGTC_143 4032-1194 15.74 µM -0.309797539566284 0.36926905856243 no 2141 0.378357461385961 674 1806963
SGTC_2493 resveratrol 26.09 µM -0.309906812865173 0.369224838993487 no 2142 0.378315910894302 659 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_546 peri-Naphthalide 147 µM -0.309944008658074 0.369209787386069 no 2143 0.378301767746572 667 223824 A penicillin ester.
SGTC_1375 2910-0797 186 µM -0.310544562231673 0.368966795826339 no 2144 0.378073438752028 687 742508
SGTC_149 3970-0822 46.1 µM -0.312122151026399 0.368328733139649 no 2145 0.377473846391764 676 3114250 YBL034C STU1
SGTC_1624 st003710 6.25 µM -0.312257981523543 0.36827381284774 no 2146 0.377422235232638 721 24207033
SGTC_648 0375-0473 33.3 µM -0.312522455255211 0.368166886010362 no 2147 0.377321750121053 691 1713139
SGTC_2479 5617353 43.85 µM -0.313091493706511 0.367936858165284 no 2148 0.377105575748617 700 2731746
SGTC_3149 9097855 49.47 µM -0.313130734226187 0.367920997339743 no 2149 0.377090669923858 665 25236625 YMR079W SEC14
SGTC_2724 maprotiline 69.64 µM -0.313425738605076 0.367801765228942 no 2150 0.376978616020361 675 4011 A tricyclic antidepressant.
SGTC_1431 4049-0260 9.09 µM -0.314538386420955 0.367352180349664 no 2151 0.37655608328416 688 3854841
SGTC_1063 disulfiram 1.84 µM -0.314938126025406 0.367190702898759 no 2152 0.376404316546404 677 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3193 9111931 49.47 µM -0.315322661371737 0.367035389472439 no 2153 0.376258340346876 690 17087244
SGTC_3077 9117319 49.47 µM -0.315410485460507 0.366999920465666 no 2154 0.376225003301538 698 17154678
SGTC_1061 3448-9325 110 µM -0.315887606691418 0.36680724811726 no 2155 0.37604390954129 714 723482
SGTC_706 4262-0057 46.9 µM -0.3160076022075 0.36675879649103 no 2156 0.375998368933903 680 883298
SGTC_2336 9001819 198.65 µM -0.316140574936675 0.366705107422964 no 2157 0.37594790524153 701 2989602
SGTC_2471 5466956 24.79 µM -0.317552381400468 0.36613523747169 no 2158 0.375412249923909 682 724419
SGTC_3258 9138477 49.47 µM -0.317696284858695 0.36607716797864 no 2159 0.375357664793804 663 4970355
SGTC_230 MPP+ 141.667 µM -0.320047619578118 0.365128767152209 no 2160 0.374466116140457 699 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1260 0700-1617 7.75 µM -0.320109182214387 0.365103947175063 no 2161 0.374442782607521 657 2853078
SGTC_974 1326-0144 138 µM -0.321625321400827 0.364492869597277 no 2162 0.373868279298063 708 5411856
SGTC_3328 9140624 29.0385 µM -0.322176205428728 0.364270921804735 no 2163 0.373659604778369 705 4904392
SGTC_1794 st048918 76.9 µM -0.322256716050803 0.364238488379105 no 2164 0.373629110506155 679 672303
SGTC_314 1671-0008 2.74 µM -0.323579074853806 0.363705919983168 no 2165 0.373128366096395 716 3913060
SGTC_2869 9037858 32.47 µM -0.326239056464918 0.362635433946618 no 2166 0.372121746822916 660 27187042
SGTC_3051 9093778 49.47 µM -0.327480408836303 0.3621362293178 no 2167 0.371652279144637 700 17217378
SGTC_1754 st042065 16.137 µM -0.327499931091559 0.362128380395082 no 2168 0.371644897535382 687 1126236 YIL048W NEO1
SGTC_364 0083-0097 67.7 µM -0.328847166007081 0.36158686480981 no 2169 0.37113560528346 710 5207356
SGTC_1507 4075-3230 155 µM -0.329998425992722 0.361124340066693 no 2170 0.370700575720515 717 659771
SGTC_591 4299-0174 154 µM -0.330874723954144 0.360772418758642 no 2171 0.37036955749198 699 5509088
SGTC_1746 st038117 42 µM -0.332259920358746 0.360216364308766 no 2172 0.369846500636721 683 2898218
SGTC_2880 9042983 58.44 µM -0.332466957975429 0.360133279300117 no 2173 0.369768342885392 719 6464714
SGTC_17 0960-0276 49.807 µM -0.333858275767795 0.359575109549062 no 2174 0.36924325305182 686 6821114
SGTC_1655 st012546 55.1 µM -0.334216769099585 0.359431337438817 no 2175 0.369107995468049 700 720985 YLR208W SEC13
SGTC_406 estrone 100 µM -0.334870527454028 0.359169201883656 no 2176 0.368861377729841 712 5870 A steroid.
SGTC_965 1291-5240 308 µM -0.337268553408136 0.358208240831783 no 2177 0.36795723155513 718 2834598
SGTC_2036 5160441 105 µM -0.339187973368612 0.357439717889164 no 2178 0.36723406434561 685 134534 YIL048W NEO1
SGTC_2353 9059630 146.67 µM -0.339653671438718 0.357253342471335 no 2179 0.367058677212933 690 4779114
SGTC_2160 5660466 132.927 µM -0.34139614728262 0.356556294591109 no 2180 0.36640268755226 758 2859134
SGTC_121 0557-0495 61.343 µM -0.34607085865216 0.354688626742518 no 2181 0.364644731632249 707 3104427
SGTC_286 k060-0067 22.9 µM -0.347311020715699 0.354193733490649 no 2182 0.364178836088923 682 5985051
SGTC_2297 7971671 152.32 µM -0.347659710844823 0.354054631143058 no 2183 0.364047878690392 728 909016
SGTC_213 1246-0773 967 nM -0.347681416764709 0.354045972681843 no 2184 0.364039727132303 704 6251622
SGTC_3220 9131269 49.47 µM -0.348323200615381 0.353790000118875 no 2185 0.363798735981517 698 17722206
SGTC_1306 1185-0270 9.02 µM -0.348347492566093 0.353780312682361 no 2186 0.363789615361747 696 1548076
SGTC_3131 9127911 49.47 µM -0.348398985638501 0.353759777968174 no 2187 0.363770282104389 724 45595681
SGTC_1574 spiramycin 23.7 µM -0.350012316841104 0.353116619911727 no 2188 0.363164727058614 683 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2026 5148700 152 µM -0.350734333752106 0.35282892199258 no 2189 0.362893832604918 684 79838
SGTC_1041 0206-0046 107 µM -0.351349653581333 0.352583805439527 no 2190 0.362663024097976 720 50494
SGTC_2536 dehydroabietamide 32.04 µM -0.35186825136276 0.352377266244932 no 2191 0.362468535094447 703 3983547
SGTC_1397 3532-0190 20.1 µM -0.355227210571835 0.351040567620197 no 2192 0.361209690611457 680 5322280
SGTC_784 4579-0127 173 µM -0.355692361836262 0.350855605325955 no 2193 0.361035482908646 729 1948547
SGTC_1007 4101-0031 70 µM -0.356214057963032 0.350648200632389 no 2194 0.360840132405165 727 1146276
SGTC_508 roscovitine 141 µM -0.357025433756819 0.350325719803173 no 2195 0.360536382725831 704 160355 A CDKinase inhibitor.
SGTC_1822 st052468 42 µM -0.357083881387497 0.350302493989307 no 2196 0.360514505446963 689 2873678
SGTC_800 3448-7362 155 µM -0.357274950270913 0.35022657128825 no 2197 0.36044299046919 723 15991913
SGTC_1730 st033808 45.1 µM -0.357507545879895 0.350134155698952 no 2198 0.360355939084349 706 1045166
SGTC_1486 3970-0793 4.53 µM -0.358119908595727 0.349890892346272 no 2199 0.360126790438531 718 2844330
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.358604991878645 0.349698234939365 no 2200 0.359945305942465 746 5282309
SGTC_904 1141-0088 396 µM -0.360889379786653 0.348791480255265 no 2201 0.359091071522874 735 1378119
SGTC_2218 6965428 192.983 µM -0.361213880985677 0.348662744088167 no 2202 0.358969783077573 696 675684
SGTC_1553 gossypol 38.6 µM -0.362989014368431 0.347958821606536 no 2203 0.358306545364304 684 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1085 doxorubicin 7.67 µM -0.364055184412546 0.347536287409972 no 2204 0.357908400716728 723 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2725 haloperidol 53.21 µM -0.364448177051676 0.347380588103443 no 2205 0.357761682669412 699 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3134 9127454 49.47 µM -0.364964212737654 0.347176179619541 no 2206 0.357569060215667 712 24262820
SGTC_2917 7979103 53.79 µM -0.365180961310847 0.347090335927951 no 2207 0.357488164529379 722 2980565
SGTC_2938 9059746 27.26 µM -0.36583361513823 0.346831898513698 no 2208 0.357244617387547 726 6471769
SGTC_1170 0310-0127 64.8 µM -0.368482455894184 0.345783744820394 no 2209 0.35625676224018 731 774975
SGTC_1349 flufenamic acid 69 µM -0.36861461964218 0.345731478120598 no 2210 0.356207498460314 703 3371 A non-steroidal anti-inflammatory.
SGTC_1924 st058459 75.1 µM -0.369762167296841 0.345277781985662 no 2211 0.35577985327108 700 688683
SGTC_3014 9081533 49.47 µM -0.370547005523286 0.344967615123562 no 2212 0.35548747984218 741 21367265
SGTC_3060 1327-0027 12.5 µM -0.370824695675309 0.34485789733346 no 2213 0.355384053116748 710 16000455 YPR107C YTH1
SGTC_942 3253-1115 227 µM -0.371497201281052 0.344592238595855 no 2214 0.355133620053351 740 46497897
SGTC_3087 9117406 49.47 µM -0.372973703396912 0.344009247449635 no 2215 0.354584007870862 695 42546093
SGTC_1801 st050089 28.441 µM -0.373058963035554 0.343975594316889 no 2216 0.354552280109603 710 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_178 4092-0806 87.505 µM -0.373626036513935 0.34375179420202 no 2217 0.354341280131219 684 2169044
SGTC_1059 3448-6867 171 µM -0.373788197637597 0.343687806071149 no 2218 0.35428095049922 700 3934407
SGTC_2429 5902844 64.44 µM -0.37566396074928 0.342947963359133 no 2219 0.353583366892996 725 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_4 0960-0234 25.671 µM -0.375909833584413 0.342851030191772 no 2220 0.353491964830801 685 6821112
SGTC_1191 1487-1166 10.6 µM -0.376522186319506 0.342609660572586 no 2221 0.353264362329675 746 3955771
SGTC_1365 1672-3266 55.4 µM -0.376692058277149 0.342542713927261 no 2222 0.353201232716407 728 6415873
SGTC_1986 st071812 45 µM -0.376835579821477 0.34248615585099 no 2223 0.353147898870514 719 11838594
SGTC_721 1187-1332 279 µM -0.377379936945905 0.342271671096013 no 2224 0.352945637285354 715 25730
SGTC_816 0325-0417 81.3 µM -0.378591602404867 0.341794439702711 no 2225 0.352495579539841 702 68101
SGTC_544 k015-0020 52.4 µM -0.379015682512986 0.341627469482555 no 2226 0.352338109103916 703 3008304
SGTC_3273 9137859 49.47 µM -0.382098609134221 0.340414582565288 no 2227 0.35119411172129 716 2377234
SGTC_615 k087-0205 167 µM -0.383082576904742 0.34002781584904 no 2228 0.350829268841562 702 9642773
SGTC_112 phenothiazine 287.218 µM -0.383886939168518 0.339711771389078 no 2229 0.350531123554398 745 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2756 carbadox 75.1 µM -0.384878793151767 0.339322214095742 no 2230 0.350163609250485 704 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_228 caffeine 993.056 µM -0.385587688667938 0.339043895795941 no 2231 0.349901026237547 713 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2491 paeonol 100 µM -0.38671684030977 0.338600762823446 no 2232 0.349482923784192 711 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1945 st075991 56.6 µM -0.388206294936354 0.338016571462143 no 2233 0.348931687544437 704 1084980
SGTC_422 cantharidin 155 µM -0.389495662030263 0.337511172849627 no 2234 0.34845475950521 700 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3271 9137798 49.47 µM -0.38954786381123 0.337490717263787 no 2235 0.348435455463727 688 6498326
SGTC_481 bay k-8644 50 µM -0.391556680108218 0.336703915661296 no 2236 0.34769290063872 761 2303 A calcium channel antagonist.
SGTC_1575 cyproterone acetate 48 µM -0.393710760162848 0.335861011517692 no 2237 0.346897298124793 760 9880 An androgen receptor antagonist and liver toxin.
SGTC_1423 4048-0112 5.59 µM -0.393882332342089 0.335793909735598 no 2238 0.346833957452561 716 X1423
SGTC_3232 9132874 49.47 µM -0.394014925476158 0.335742056221791 no 2239 0.346785009917952 728 3784940
SGTC_2568 diosmetin 100 µM -0.394614198234484 0.335507736211714 no 2240 0.346563816764368 761 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2853 9015042 58.44 µM -0.396800843479819 0.334653285066144 no 2241 0.345757164339976 689 6457456
SGTC_3277 9138724 49.47 µM -0.397129577064649 0.33452490335562 no 2242 0.345635955085948 701 15943418
SGTC_87 0100-0052 35.5 µM -0.397819425886051 0.334255556703884 no 2243 0.345381648407388 729 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_3108 9121785 49.47 µM -0.398253998809805 0.334085924535731 no 2244 0.345221482754158 673 17140271
SGTC_252 miconazole 1.30953 nM -0.398364144896961 0.334042935247159 no 2245 0.345180891851958 724 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1142 3253-1408 9.78 µM -0.398511714962559 0.333985343040482 no 2246 0.345126512302286 737 256655
SGTC_2768 sulfasalazine 50.2 µM -0.39945501316188 0.333617294233469 no 2247 0.344778982636698 762 5384001 An antioxidant and salicylic acid derivative.
SGTC_428 3448-4153 16.5 µM -0.400759543468574 0.333108566464807 no 2248 0.344298583723995 697 3834874
SGTC_1572 epiandrosterone 68.9 µM -0.401097304546973 0.332976899742922 no 2249 0.344174242643442 710 441302 A steroid.
SGTC_2642 cholecalciferol 100 µM -0.401499403927112 0.332820179377688 no 2250 0.344026238458659 742 9821465 A vitamin D precursor, similar to steriods.
SGTC_597 k018-0003 82.8 µM -0.402745194929599 0.33233481123537 no 2251 0.3435678411972 752 6786234
SGTC_59 0330-0160 1.33 µM -0.403060424092566 0.332212040461043 no 2252 0.343451886914104 734 4293482
SGTC_451 chloral hydrate 100 µM -0.404347596600729 0.331710918601414 no 2253 0.342978564788844 747 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_450 aminopyrene 156 nM -0.406699379432243 0.330796100629564 no 2254 0.342114398170266 737 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_788 1182-0090 188 µM -0.407033814216313 0.330666091002116 no 2255 0.341991576539777 704 5715185
SGTC_189 3970-0742 2.116 µM -0.407083652065369 0.330646718569138 no 2256 0.341973274952781 745 2891807
SGTC_90 0870-0863 4.608 µM -0.408633523518297 0.330044495844099 no 2257 0.34140431255772 742 1738164
SGTC_1778 st046819 58.9 µM -0.409260701489687 0.329800922679587 no 2258 0.341174175984569 730 671715
SGTC_3029 9088683 49.47 µM -0.409753137969602 0.329609728783022 no 2259 0.340993522819618 720 25236615
SGTC_231 b-estradiol 524 µM -0.409980045326895 0.329521644480189 no 2260 0.340910292810437 698 450 A steroid.
SGTC_768 0384-0033 77.3 µM -0.409993727060407 0.329516333601856 no 2261 0.340905274574494 738 3965305 YMR134W ERG29
SGTC_2217 6934799 96.0675 µM -0.410134294338185 0.329461771184012 no 2262 0.340853718427884 733 675606
SGTC_2774 tamoxifen 10.92 µM -0.41151614365897 0.328925587723678 no 2263 0.340347053096907 719 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2816 7982706 58.44 µM -0.411548974015792 0.328912853204107 no 2264 0.340335019102121 728 2981853
SGTC_2566 crystal violet carbinol 226 nM -0.413174382428238 0.32828262445708 no 2265 0.339739427802755 759 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_3344 9148862 3.898 µM -0.414218393908027 0.327878081477819 no 2266 0.339357086052548 757 4905352
SGTC_41 0478-0632 82.643 µM -0.414524432065678 0.327759533296888 no 2267 0.339245038940963 757 3750424
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.41614465736448 0.327132205691869 no 2268 0.338652076845996 713 16486 A toxic proline analog.
SGTC_1226 3909-7979 35.4 µM -0.416612742678549 0.326951060675978 no 2269 0.338480843637004 718 6615510
SGTC_2023 5144124 124 µM -0.417013870814353 0.326795859951346 no 2270 0.338334131016345 734 2830192
SGTC_2916 7875993 68.79 µM -0.417620962156051 0.326561026874684 no 2271 0.338112134031199 774 1299250
SGTC_611 3453-1652 23.7 µM -0.420602107903062 0.325408868459179 no 2272 0.337022827125535 745 1560575
SGTC_795 0685-0265 78 µM -0.422486074700075 0.324681608266864 no 2273 0.336335131410086 715 302754
SGTC_1439 4092-1168 46 µM -0.422912353560062 0.324517146095195 no 2274 0.336179604638587 732 2886240
SGTC_994 3910-0338 138 µM -0.423850992738534 0.324155131415 no 2275 0.335837243356461 735 3479481
SGTC_2186 6124449 200 µM -0.424102444182026 0.324058179746477 no 2276 0.335745551530258 718 3834182 YLR033W RSC58
SGTC_123 0083-0120 66.675 µM -0.424759782304715 0.323804787480962 no 2277 0.33550589923584 720 16001701
SGTC_3031 9088762 49.47 µM -0.424900497512728 0.323750554852789 no 2278 0.335454605984601 733 205253
SGTC_350 k064-0020 19.8 µM -0.424996950969893 0.323713383175432 no 2279 0.335419448717574 743 2790705
SGTC_125 0133-0007 11.75 µM -0.425616887449829 0.32347451118862 no 2280 0.335193516397214 737 26541
SGTC_983 1491-0821 12.2 µM -0.426295319086098 0.323213183380685 no 2281 0.334946334159973 710 46495113
SGTC_13 0199-0087 65 µM -0.42819247162028 0.322482874841114 no 2282 0.334255498444908 732 4589825
SGTC_640 3381-0960 37.1 µM -0.428605431546064 0.322323996602348 no 2283 0.334105196056678 730 1745025
SGTC_2821 7996764 71.43 µM -0.428827023032403 0.322238756996954 no 2284 0.334024555782975 684 2987135
SGTC_2237 6667747 47.222 µM -0.431381363187964 0.321256854728153 no 2285 0.33309554936255 724 729940 YDL015C TSC13
SGTC_1380 2291-0730 164 µM -0.432538192066385 0.320812573593254 no 2286 0.332675150214766 731 2999191
SGTC_2833 9001315 45.46 µM -0.433078446118023 0.320605176380761 no 2287 0.332478890387374 710 2989378
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.434053747047513 0.320230911575412 no 2288 0.332124705972462 742 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2907 7721985 69.9 µM -0.434340277485001 0.320120992281002 no 2289 0.332020679780747 730 3267881
SGTC_2782 7736369 71.43 µM -0.434555592570134 0.320038403128882 no 2290 0.331942517168524 724 2950836 YOL077C BRX1
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.434600560783734 0.320021155641159 no 2291 0.331926193954137 708 6708630 An antioxidant.
SGTC_426 0988-0037 14.6 µM -0.434913721157432 0.319901054260098 no 2292 0.33181252730743 758 5383008
SGTC_1237 0330-0133 46.1 µM -0.436107118717736 0.319443542726664 no 2293 0.331379506246433 759 X1237 YHR072W ERG7
SGTC_1327 1436-0082 2.18 µM -0.436317220575261 0.319363024625997 no 2294 0.331303294669014 729 15992205
SGTC_2367 9070478 135.38 µM -0.436445211767226 0.319313978269593 no 2295 0.331256871037377 720 572802
SGTC_2259 7964009 200 µM -0.436706684431669 0.31921379150325 no 2296 0.331162040457515 725 313134
SGTC_3299 9121982 43.1275 µM -0.437806693152944 0.318792453033357 no 2297 0.330763209322315 742 17594604 YPL160W CDC60
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.439324128294318 0.318211611208265 no 2298 0.330213346759538 749 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2162 5663267 200 µM -0.4406329450317 0.31771098279334 no 2299 0.329739374115522 763 6456493
SGTC_1961 st076550 68.7 µM -0.44081102706198 0.317642891323155 no 2300 0.329674904900741 735 1579337
SGTC_2236 dapsone 200 µM -0.440854399630362 0.317626308315771 no 2301 0.329659203940026 733 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_641 4092-0595 30 µM -0.440864405717654 0.317622482654236 no 2302 0.32965558175806 724 786260
SGTC_2391 6285546 200 µM -0.441702868228875 0.317301979639274 no 2303 0.329352116937892 722 846083
SGTC_1426 4048-4480 71.7 µM -0.442204296017088 0.317110373860887 no 2304 0.329170688811139 733 14224343
SGTC_2861 9024595 19.48 µM -0.444814817552164 0.316113633271526 no 2305 0.328226792634766 716 16482810
SGTC_1434 4073-0095 163 µM -0.4448193480692 0.316111904603114 no 2306 0.328225155469226 751 24133745
SGTC_2978 9011784 42.97 µM -0.445116510804718 0.315998527686377 no 2307 0.328117778775457 715 2994934
SGTC_1694 st024011 44.9 µM -0.445124979371421 0.315995296915749 no 2308 0.328114718954199 765 2787533
SGTC_1804 st050076 49.1 µM -0.44558571427032 0.315819547061684 no 2309 0.327948265854175 738 3895976
SGTC_1845 st056753 3.01 µM -0.447768949066622 0.314987306750453 no 2310 0.327159977546221 711 5375839
SGTC_3123 9126162 49.47 µM -0.448565783414444 0.314683790240311 no 2311 0.326872460754614 700 25239884
SGTC_513 4245-1575 41.7 µM -0.449194016845966 0.314444582535027 no 2312 0.32664585161648 726 719745
SGTC_2419 paclitaxel 166.5 µM -0.449691760648253 0.314255115673092 no 2313 0.32646635659091 745 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_22 0964-0034 14.468 µM -0.450830989314869 0.313821650934405 no 2314 0.326055682277759 757 138402
SGTC_2520 obtusaquinone 4.71 µM -0.453359097210256 0.312860650003954 no 2315 0.325145092292081 744 5967872
SGTC_723 4182-0001 115 µM -0.453841668204355 0.312677356147778 no 2316 0.32497139521365 741 744821 YLR208W SEC13
SGTC_1651 st011928 86.1 µM -0.454064332972232 0.312592797502253 no 2317 0.324891261860675 736 720198
SGTC_1180 1193-0155 285 µM -0.457211532951297 0.311398681012443 no 2318 0.323759504808195 761 2921347
SGTC_103 0844-0104 51.839 µM -0.458159273584799 0.311039475109106 no 2319 0.323419008479138 749 5375804
SGTC_586 0957-0265 8.15 µM -0.458284900405771 0.310991874425522 no 2320 0.32337388541572 742 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1287 0971-0001 34.6 µM -0.460197859303517 0.310267434968125 no 2321 0.322687103699178 718 4665869
SGTC_3099 9120367 49.47 µM -0.460435707348271 0.310177413034959 no 2322 0.322601754787594 752 24824940
SGTC_475 α-linolenic acid 10 µM -0.460779980832583 0.310047130810365 no 2323 0.32247823294248 739 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1247 0448-0043 5.84 µM -0.461191344780535 0.309891491041055 no 2324 0.322330665411025 758 3089013 YGL099W LSG1
SGTC_2247 cerulenin 830 nM -0.463343411558632 0.309077811224178 no 2325 0.321559116781609 717 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1283 0922-0125 16.4 µM -0.464143727534524 0.308775456425193 no 2326 0.321272387352247 728 3360884
SGTC_596 1155-0152 116 µM -0.4646088247724 0.308599804860558 no 2327 0.321105805749784 734 280313
SGTC_2291 7917025 104.35 µM -0.464710796015687 0.308561299607266 no 2328 0.321069288018117 728 2964612
SGTC_270 tamoxifen 5.46 µM -0.466224814071592 0.307989840708674 no 2329 0.320527294732556 744 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1990 st072050 59.8 µM -0.466305479000739 0.307959407158918 no 2330 0.320498428751637 731 17233948
SGTC_62 0180-0423 3.232 µM -0.466358836486715 0.30793927698364 no 2331 0.320479335348076 772 30102 YGL099W LSG1
SGTC_2507 purpurin 79.67 µM -0.466449586338754 0.307905041120215 no 2332 0.320446862578951 731 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2324 6149169 200 µM -0.46690800716127 0.307732124992083 no 2333 0.320282848134645 759 2888231
SGTC_1711 st032263 62.8 µM -0.467218584242449 0.307614999716891 no 2334 0.320171749376176 749 3958979
SGTC_995 3931-2021 34.6 µM -0.469783117715963 0.306648609461373 no 2335 0.319254988575271 752 730143
SGTC_1734 st037168 69.4 µM -0.473248127459812 0.305345026846116 no 2336 0.318018082660525 748 708907
SGTC_1501 4491-0275 38.4 µM -0.473765802134232 0.305150481993725 no 2337 0.317833461851885 755 5104718
SGTC_554 4483-2211 187 µM -0.474116173473108 0.305018841840019 no 2338 0.317708532924692 742 747107
SGTC_3110 9122132 49.47 µM -0.474183673630419 0.304993483841714 no 2339 0.317684467351522 723 918317
SGTC_2376 9072922 81.32 µM -0.474330435993092 0.304938352390597 no 2340 0.317632145385291 762 17087968
SGTC_2308 7584454 197.62 µM -0.475655437600987 0.30444081455982 no 2341 0.317159936605869 758 893577
SGTC_1545 lovastatin 49.4 µM -0.477907213915774 0.30359610292403 no 2342 0.316358123340769 741 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1048 3161-0300 24.5 µM -0.478201416646896 0.303485815624687 no 2343 0.316253427165045 725 2165101
SGTC_3173 9105693 49.47 µM -0.478202156400908 0.30348553833686 no 2344 0.316253163931746 790 17096658
SGTC_35 0133-0054 64.071 µM -0.478286429299244 0.303453950402927 no 2345 0.316223176960744 760 99677
SGTC_2149 5554786 194.827 µM -0.478715299585709 0.303293220104762 no 2346 0.316070590035859 749 745063 YPR165W RHO1
SGTC_165 k038-0023 64.381 µM -0.478799806708979 0.303261553350141 no 2347 0.316040527104423 739 46368543
SGTC_856 0433-0016 11.3 µM -0.4791358375532 0.303135649523125 no 2348 0.315920998067354 750 3911780
SGTC_2713 st079149 53.4 µM -0.482723370342486 0.301792934876008 no 2349 0.314646083547002 730 3103253
SGTC_1104 tacrolimus 29.8 µM -0.483100766170299 0.301651841552645 no 2350 0.314512095042737 747 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2800 7887935 81.82 µM -0.483217309178076 0.301608276742715 no 2351 0.314470723200556 774 2961002
SGTC_132 0417-1715 25.805 µM -0.484569816545357 0.301102904633167 no 2352 0.313990764348091 778 6769098
SGTC_2759 disulfiram 3.38 µM -0.48484860900625 0.300998779691411 no 2353 0.313891869455901 735 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3223 9129970 49.47 µM -0.485266688709006 0.300842663415986 no 2354 0.313743590833062 733 17248386
SGTC_1236 0330-0013 258 µM -0.485381065343161 0.300799960090584 no 2355 0.313703030578122 763 4617066
SGTC_1671 st016596 74.5 µM -0.485567709547388 0.300730281029636 no 2356 0.313636847624702 739 2829167
SGTC_2862 9027634 71.43 µM -0.48612089711193 0.30052380474495 no 2357 0.313440725758193 739 5012562
SGTC_3121 9125696 49.47 µM -0.486173558066419 0.300504152474121 no 2358 0.313422058591615 773 1235365
SGTC_1884 5633444 25 µM -0.487080453502897 0.300165803936602 no 2359 0.313100658840893 743 5724239
SGTC_471 1-acyl-paf 4 µM -0.488896383336894 0.299488827219915 no 2360 0.312457528163349 737 16759367
SGTC_3048 9093155 49.47 µM -0.490982001689569 0.298712166022283 no 2361 0.311719588705966 749 25236002
SGTC_113 0099-0221 2.5 µM -0.492811376623418 0.298031681791583 no 2362 0.311072935720948 753 89219
SGTC_2968 9090663 33.37 µM -0.493861582889143 0.297641349352914 no 2363 0.310701968814269 766 25236811
SGTC_2893 9048488 25.97 µM -0.496180015870645 0.296780479450786 no 2364 0.309883704588163 737 6467338
SGTC_2071 5230951 39.92 µM -0.497123822794371 0.296430356140679 no 2365 0.309550868051149 762 1799272
SGTC_45 0kpi-0036 14.9 µM -0.497132344146034 0.296427195844135 no 2366 0.309547863680007 771 2795021
SGTC_2704 st078022 71.1 µM -0.497249660911984 0.296383688381185 no 2367 0.309506502626665 781 54697681
SGTC_663 1486-0733 13.9 µM -0.497292782248401 0.296367697370768 no 2368 0.30949130042822 767 722445 YPR165W RHO1
SGTC_1999 st074831 12.5 µM -0.498531356081778 0.2959085566406 no 2369 0.309054787031198 789 17112523
SGTC_1082 camptothecin 424.86 nM -0.498878304149098 0.295780001185899 no 2370 0.308932559622411 775 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1190 1486-1332 13 µM -0.499977409609092 0.295372916640149 no 2371 0.30854549206426 772 4150046
SGTC_3167 9103034 49.47 µM -0.500758175228709 0.295083894875198 no 2372 0.308270662129919 746 5127859
SGTC_1806 st050005 60.3 µM -0.501146232044681 0.294940293495854 no 2373 0.308134105872941 744 5194765
SGTC_483 fpl-64176 144 µM -0.503668220875971 0.294007811015189 no 2374 0.307247271847252 773 3423
SGTC_3350 9150499 3.57 µM -0.504095612929089 0.293849921841476 no 2375 0.307097094829419 767 4910996 YPR165W RHO1
SGTC_846 0335-0850 148 µM -0.504297545116503 0.29377533675319 no 2376 0.307026151150645 770 6819598
SGTC_3032 9089427 49.47 µM -0.504743357444019 0.293610703826329 no 2377 0.306869552042115 756 17173707
SGTC_1852 st056254 31.4 µM -0.506287413287047 0.293040833704964 no 2378 0.306327448842712 758 442583
SGTC_3274 9138298 49.47 µM -0.507034021730349 0.292765464458309 no 2379 0.306065473658214 768 17015756
SGTC_1410 3909-8106 77.9 µM -0.507628568035258 0.292546265788741 no 2380 0.30585692601153 778 1039210
SGTC_2565 isoliquiritigenin 100 µM -0.508011376711829 0.292405171397619 no 2381 0.305722682389315 730 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1764 st044502 93.5 µM -0.508278452565011 0.292306752178769 no 2382 0.30562903949512 747 8407
SGTC_1323 1348-1351 11.2 µM -0.508385948383619 0.292267143607378 no 2383 0.305591352593251 769 6989654
SGTC_111 0083-0039 52.457 µM -0.508594339386495 0.292190365686861 no 2384 0.305518298768938 766 759313
SGTC_2874 9043904 71.43 µM -0.509018086861522 0.292034272493294 no 2385 0.305369773176948 761 4463428
SGTC_1649 st011737 51.3 µM -0.509165496743354 0.291979981144242 no 2386 0.305318112791013 748 1761035
SGTC_528 3492-0019 172 µM -0.510191362844682 0.29160228286577 no 2387 0.304958701318503 760 2869262
SGTC_1830 st055982 50.3 µM -0.511689207339662 0.291051223405539 no 2388 0.304434270373466 797 455313 An antimicrobial agent.
SGTC_2714 st079313 56.9 µM -0.514208956371366 0.290125302683996 no 2389 0.303552953288054 775 2939799
SGTC_2179 6298986 200 µM -0.515020658152716 0.289827324553351 no 2390 0.303269292176906 764 738374
SGTC_630 4356-0227 183 µM -0.51559303118419 0.289617291066098 no 2391 0.30306933928138 786 779312
SGTC_686 1319-0111 510 µM -0.515846118239894 0.289524443026909 no 2392 0.302980944613635 817 4562600
SGTC_2796 7949634 45.45 µM -0.517201008244338 0.289027623159326 no 2393 0.302507924142217 751 2971588
SGTC_2074 5212007 75.395 µM -0.517660924805308 0.288859069183393 no 2394 0.302347432937529 761 758611
SGTC_2720 fluspirilene 36.88 µM -0.5186493647045 0.288496974308734 no 2395 0.302002639019071 773 3396 An atypical antipsychotic.
SGTC_555 4296-0685 37 µM -0.518710977850004 0.28847441066866 no 2396 0.301981152576558 781 2908540 YHR072W ERG7
SGTC_3074 9116018 49.47 µM -0.519860137147454 0.288053724127714 no 2397 0.301580530476216 813 17027303
SGTC_2120 5538279 151.968 µM -0.519934200041326 0.288026620969894 no 2398 0.301554718732192 760 2058197
SGTC_3080 9117754 49.47 µM -0.520265003305433 0.287905578919265 no 2399 0.301439442243064 789 9550191
SGTC_218 alverine citrate 93.75 µM -0.52268267837298 0.287021673410112 no 2400 0.300597547121633 766 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_524 r073-0010 27.8 µM -0.5228806958245 0.286949334925513 no 2401 0.300528639534828 785 2772106
SGTC_999 SEC7.066 22.7 µM -0.522927521990574 0.286932229949102 no 2402 0.300512345659931 761 740511 YDR170C SEC7
SGTC_2952 9073731 13.78 µM -0.524124493265876 0.286495156325678 no 2403 0.300095976866103 781 16457353
SGTC_1364 1653-0028 37.6 µM -0.525908079350491 0.285844467183498 no 2404 0.299476037552968 761 5718652
SGTC_281 1672-3440 14.9 µM -0.526108935914737 0.285771234596357 no 2405 0.299406260162875 774 6833000
SGTC_80 0159-0065 512.242 µM -0.526469292141902 0.285639870578092 no 2406 0.299281091214815 738 1548079
SGTC_572 0960-0087 17.7 µM -0.52703753223923 0.285432783111253 no 2407 0.299083762505303 776 6796365
SGTC_110 0850-0284 111.64 µM -0.527882079908905 0.285125131215142 no 2408 0.29879059160874 763 3906265
SGTC_2777 climbazole 1.536 µM -0.529158552048014 0.284660438049071 no 2409 0.298347733259232 776 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_3056 9094900 49.47 µM -0.529928203634019 0.28438042515488 no 2410 0.298080855351004 769 25236784
SGTC_1881 5652484 16 µM -0.531105098601684 0.283952504582113 no 2411 0.297672975628679 782 2255129
SGTC_2214 7179297 48.276 µM -0.531736807456393 0.283722941559072 no 2412 0.29745414764571 747 769744
SGTC_3238 9133470 49.47 µM -0.531832274368184 0.28368825661192 no 2413 0.297421083688548 762 3534688
SGTC_3021 9087658 49.47 µM -0.532525692790702 0.283436385459871 no 2414 0.297180975929541 765 25237042
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.533572511456317 0.283056351528081 no 2415 0.29681866536284 774 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_835 0312-0010 67.2 µM -0.533916094950993 0.282931671328701 no 2416 0.296699793025096 772 1626196
SGTC_445 e6 berbamine 66 µM -0.534113630679427 0.282860001147134 no 2417 0.296631459875597 789 6610268 A calcium/calmodulin antagonist.
SGTC_2792 7535235 81.82 µM -0.534513282201445 0.282715025709973 no 2418 0.296493231253032 740 1281891
SGTC_2607 solasodine 47.35 µM -0.534650710261211 0.282665181296879 no 2419 0.296445705435548 760 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2499 avocadenofuran 51.48 µM -0.535255163703031 0.282445999459026 no 2420 0.296236712848785 777 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2898 9056270 58.44 µM -0.540494591638143 0.280549554889404 no 2421 0.294427994894844 750 19154699
SGTC_2987 9018338 71.43 µM -0.541387680690501 0.280226911326912 no 2422 0.294120198322463 776 5055682
SGTC_569 4130-2812 160 µM -0.54177426363202 0.280087307450797 no 2423 0.293987011485833 790 743552
SGTC_2447 5741742 33.78 µM -0.543462592485824 0.27947800894795 no 2424 0.293405669919166 759 1776504
SGTC_416 estradiol valerate 100 µM -0.545691332132356 0.278674669412409 no 2425 0.292639065581675 778 13791 A steroid.
SGTC_2167 5876490 200 µM -0.545772935764396 0.278645277086843 no 2426 0.29261101460482 801 686534
SGTC_1597 7-benzyloxygramine 47.5 µM -0.547056358902412 0.278183207233081 no 2427 0.292170006590173 789 260807
SGTC_1777 st045864 34.765 µM -0.547172701157835 0.278141339098445 no 2428 0.292130044524871 795 4691462
SGTC_666 0272-0154 136 µM -0.547250495245561 0.278113345023263 no 2429 0.292103324677537 773 6870312
SGTC_2365 9042475 200 µM -0.549329242370983 0.277365820706464 no 2430 0.29138976141475 769 6464479
SGTC_2945 9067681 61.76 µM -0.5514687442181 0.276597476124185 no 2431 0.290656193555856 812 16456930
SGTC_363 0455-0021 3.06 µM -0.551926196987712 0.276433329737429 no 2432 0.290499459563094 777 4597466
SGTC_1993 st073995 70.8 µM -0.55244197074637 0.276248313522174 no 2433 0.290322790895296 782 3098394
SGTC_1321 1326-2144 215 µM -0.552461478171068 0.276241317092739 no 2434 0.290316109978923 794 3513030
SGTC_172 1112-0046 2.638 µM -0.553493971045506 0.275871132821795 no 2435 0.289962603901425 786 2802135 YIL048W NEO1
SGTC_3037 9091026 49.47 µM -0.553656735725958 0.275812798321699 no 2436 0.289906894767957 787 25236398 YIL048W NEO1
SGTC_2992 9074591 71.4286 µM -0.554091677273772 0.275656945982365 no 2437 0.289758052849582 790 17741321
SGTC_834 0312-0008 75.7 µM -0.554195371233647 0.275619795781542 no 2438 0.289722572897349 791 6385573 YIL048W NEO1
SGTC_219 mitoxanthrone 164.414 µM -0.555051670903625 0.275313105367907 no 2439 0.289429659141454 793 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1903 st060211 78.3 µM -0.557161066634182 0.274558326042126 no 2440 0.288708693852019 773 688960
SGTC_225 nsc-122657 1.016 µM -0.557634878520402 0.274388928229861 no 2441 0.288546867220101 793 275685
SGTC_950 1165-0508 94.1 µM -0.561771102394971 0.272912335012286 no 2442 0.287135991594767 767 6148369
SGTC_2635 hydroquinidine 100 µM -0.561883779792042 0.272872165437384 no 2443 0.287097602813124 784 442912 An experimental heart treatment.
SGTC_1391 3442-0225 151 µM -0.56200570575565 0.272828702045281 no 2444 0.287056065816116 769 5227075
SGTC_366 0181-0206 4.31 µM -0.562771130717335 0.272555926694627 no 2445 0.286795370522297 795 274874
SGTC_1902 st060212 70.5 µM -0.563698983180079 0.272225448516464 no 2446 0.286479504762155 761 688944
SGTC_2057 5236571 38.335 µM -0.564689688436339 0.271872803693899 no 2447 0.286142424562165 770 54684039 YBR257W POP4
SGTC_2663 amphotericin b 100 µM -0.564701005543885 0.27186877664525 no 2448 0.286138575087947 775 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_476 mead acid 10 µM -0.566628050820102 0.271183495186464 no 2449 0.285483456449788 788 5312531 An omega 9 fatty acid.
SGTC_2921 7974240 10.71 µM -0.567431612329226 0.270897993294191 no 2450 0.28521048866949 788 2979074 YDR527W RBA50
SGTC_2855 9016525 58.44 µM -0.568609608542336 0.27047972768762 no 2451 0.284810551335336 780 43811474
SGTC_371 0195-0006 7.36 µM -0.569712824375058 0.270088306831448 no 2452 0.284436245252743 775 3928593
SGTC_1468 k284-1086 134 µM -0.570172543032545 0.269925282389354 no 2453 0.2842803383865 783 15996457
SGTC_3302 9125395 16.351 µM -0.570278871705177 0.269887583358469 no 2454 0.28424428438811 771 17599668
SGTC_2465 5809242 33.21 µM -0.57058233953818 0.269780002765456 no 2455 0.28414139633395 818 2731748
SGTC_1870 st057514 26.5 µM -0.570979829862202 0.269639123305025 no 2456 0.284006657743968 775 5393161
SGTC_940 3232-1287 54.8 µM -0.572502677662281 0.269099733289464 no 2457 0.283490736160071 802 1585493 YIL048W NEO1
SGTC_322 k048-0136 19.3 µM -0.572844652500472 0.268978680891523 no 2458 0.283374941197625 776 6823282
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.573559324441012 0.268725789303458 no 2459 0.283133021750968 821 65057 A dermal irritant. YDR527W RBA50
SGTC_400 oxethazaine 37.5 µM -0.573847143984165 0.268623976126057 no 2460 0.283035621629136 793 4621 A local anesthetic.
SGTC_2359 9039622 200 µM -0.574452981987071 0.268409730583337 no 2461 0.282830654435042 789 6463596
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.57516222976896 0.268159024946143 no 2462 0.28259079225534 801 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1670 st016595 4.04 µM -0.575166047115708 0.268157675905391 no 2463 0.282589501522453 812 597879
SGTC_1995 st072814 61.1 µM -0.576256873554913 0.267772320568719 no 2464 0.282220784128743 765 5769371
SGTC_1225 1216-0074 20.6 µM -0.5768126681582 0.267576082832801 no 2465 0.282033005437599 798 4241466
SGTC_2780 5215298 71.43 µM -0.577584392427288 0.267303725793194 no 2466 0.281772373372522 805 2834131
SGTC_2848 9016370 25.97 µM -0.577784731848148 0.267233044852286 no 2467 0.281704732341181 777 7894410
SGTC_258 haloperidol 50.781 µM -0.578346801492121 0.267034793700089 no 2468 0.281515001355013 801 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2608 thymoquinone 42.66 µM -0.579100498791425 0.266769068959406 no 2469 0.281260681754187 791 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1162 k048-0130 20.1 µM -0.579714085167573 0.266552840676149 no 2470 0.281053721638257 799 6797406
SGTC_3306 9127676 59.7925 µM -0.579769353422486 0.266533368455313 no 2471 0.281035083499957 770 41905287
SGTC_1108 betulinic acid 729.144 nM -0.580069754759869 0.266427543045667 no 2472 0.280933789468344 764 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2159 5658611 73.75 µM -0.580410877565745 0.266307398053355 no 2473 0.28081878573424 789 793844
SGTC_884 0851-0618 334 µM -0.581985239868727 0.265753256072637 no 2474 0.280288311499522 803 9642473
SGTC_81 0411-0046 9.971 µM -0.582270035330417 0.265653076609758 no 2475 0.280192402826531 798 12925265
SGTC_847 0342-0274 5.54 µM -0.583450432794239 0.265238065051817 no 2476 0.279795057836152 783 18097
SGTC_3143 9086658 49.47 µM -0.584501718199145 0.264868724865548 no 2477 0.279441404803882 773 25236626
SGTC_670 4204-0025 119 µM -0.584652667681509 0.264815714390876 no 2478 0.279390643138773 783 719039
SGTC_308 4092-1169 104 µM -0.585627705379612 0.264473430410399 no 2479 0.279062863005978 803 2268590 YDL196W YDL196W
SGTC_1910 st062352 60.4 µM -0.587420196719556 0.263844769783046 no 2480 0.278460766375852 771 2245730
SGTC_583 1488-1091 88.9 µM -0.587698182664142 0.263747343137837 no 2481 0.278367447806418 805 4303273
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.587977593164325 0.263649435716104 no 2482 0.278273666382163 811 23665772 A membrane-active detergent.
SGTC_3288 9119690 36.221 µM -0.588248543385422 0.263554510547048 no 2483 0.278182739281644 820 17595618 YKL019W RAM2
SGTC_738 1315-0003 72.4 µM -0.589557613076157 0.263096134618858 no 2484 0.277743638039436 815 6251474
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.590542547867169 0.262751524561317 no 2485 0.277413484661312 777 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1838 st055369 84.5 µM -0.590839129839787 0.262647801385882 no 2486 0.277314107007405 762 676036
SGTC_3007 9078383 71.4286 µM -0.592216805233808 0.26216626385008 no 2487 0.276852708732042 781 6496995
SGTC_1376 2910-0861 41.3 µM -0.5922644451619 0.262149620408179 no 2488 0.276836760336634 808 1112859
SGTC_1013 4112-3890 241 µM -0.593913188567392 0.261573950718507 no 2489 0.276285088745655 801 705171
SGTC_3063 1327-0034 4 µM -0.594534277687588 0.26135726171807 no 2490 0.276077411511354 800 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2299 7976368 114.88 µM -0.595095857133066 0.261161414183667 no 2491 0.275889698881607 787 2979718
SGTC_1346 1488-2224 62.4 µM -0.595483111900093 0.261026405308586 no 2492 0.275760292271082 797 3722427
SGTC_1234 0326-0494 15.5 µM -0.595899684093493 0.260881215551749 no 2493 0.275621122143887 819 1547813
SGTC_2124 5246320 200 µM -0.596266213251042 0.260753501878071 no 2494 0.275498699163924 785 579342
SGTC_1779 st039427 55 µM -0.597390526438962 0.26036194619981 no 2495 0.275123338621725 823 1124498
SGTC_3176 9106582 49.47 µM -0.597420819530133 0.260351400456013 no 2496 0.275113228527327 769 17018027
SGTC_2935 9038016 29.96 µM -0.599310116830803 0.259694126325966 no 2497 0.27448305136185 792 6463195
SGTC_1250 0485-0349 40.2 µM -0.599419935532635 0.259655947475788 no 2498 0.274446443131426 797 6842794 YDL195W SEC31
SGTC_1405 3909-7894 12 µM -0.59974809457658 0.259541879120278 no 2499 0.274337065177755 798 7104060
SGTC_2013 4024628 200 µM -0.600512964316013 0.259276110243385 no 2500 0.274082211729024 817 5230760
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.602645396349744 0.258535898548196 no 2501 0.273372306842792 774 6708561
SGTC_191 3914-0123 66.505 µM -0.603429927464738 0.258263847064426 no 2502 0.273111359020376 814 3144412
SGTC_173 1273-0061 2.693 µM -0.603617860588451 0.258198699619733 no 2503 0.273048867736118 797 2847414 YPL266W DIM1
SGTC_6 0844-0013 19.835 µM -0.604591903137301 0.257861182106397 no 2504 0.272725093951964 821 1584900
SGTC_287 k060-0039 29.6 µM -0.604656317051949 0.257838869980035 no 2505 0.272703689349118 794 5861974
SGTC_2634 4'-methoxyflavone 100 µM -0.60495031526849 0.257737045617505 no 2506 0.272606004971957 779 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1383 3049-0032 20.7 µM -0.605015290174385 0.257714544799821 no 2507 0.272584418636364 810 712864
SGTC_2850 9015429 58.44 µM -0.605628184557127 0.257502349589524 no 2508 0.272380841113634 821 6457570
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.607884464081085 0.256721967221469 no 2509 0.271632052123562 820 364106
SGTC_1014 4130-3005 69.3 µM -0.609882607896546 0.256031896030957 no 2510 0.270969787163106 801 743608
SGTC_2150 5556613 200 µM -0.610441968091274 0.255838891064091 no 2511 0.270784537198906 808 743190
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.610462986445139 0.255831640246952 no 2512 0.270777577533476 802 616764
SGTC_854 0422-0053 192 µM -0.610618804068133 0.255777890329709 no 2513 0.270725985482295 796 3596728
SGTC_11 0438-0307 1.3 µM -0.610681772116341 0.255756170920274 no 2514 0.270705137816161 810 4011476
SGTC_3264 9137442 49.47 µM -0.610796362912899 0.255716647877568 no 2515 0.27066720077956 798 17015726
SGTC_3141 9094609 49.47 µM -0.612319694216 0.255191545041246 no 2516 0.270163131026421 809 25236309 YDL196W YDL196W
SGTC_707 0865-0008 204 µM -0.613199515601872 0.254888521595741 no 2517 0.269872212515657 814 723043
SGTC_1725 st036284 20.55 µM -0.614714446178226 0.254367198815028 no 2518 0.269371658902242 778 707914
SGTC_1773 st048542 73.5835 µM -0.615738527829956 0.254015105394697 no 2519 0.269033552324373 816 3237138
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.618228625245945 0.253160043469207 no 2520 0.268212321638542 804 75037 A free radical scavenger.
SGTC_716 1683-5115 658 µM -0.619006436043826 0.252893265580105 no 2521 0.267956059491904 818 723597
SGTC_298 1391-0729 10 µM -0.620865687672231 0.252256169156707 no 2522 0.267343999469735 808 3237558
SGTC_3189 9110682 49.47 µM -0.621395402798287 0.252074810501546 no 2523 0.26716974804142 808 17122418
SGTC_2621 lithochol-11-enic acid 100 µM -0.621909645669913 0.251898814908866 no 2524 0.267000641118251 827 6708711
SGTC_3098 9119039 49.47 µM -0.622451101645391 0.251713575964548 no 2525 0.266822643705922 812 17161528
SGTC_2383 9036125 200 µM -0.622592572967292 0.251665188690127 no 2526 0.266776146520985 803 79580
SGTC_887 0885-0007 9.62 µM -0.622960868172774 0.251539244148139 no 2527 0.266655118651319 798 5719458
SGTC_1657 st012939 43.4 µM -0.623190237589029 0.251460824372884 no 2528 0.26657975811339 808 24207257
SGTC_418 lividomycin a 100 µM -0.623431246871236 0.251378438932339 no 2529 0.266500584840943 795 72394 An antibiotic.
SGTC_316 k060-0003 58.6 µM -0.623818964783902 0.251245933271693 no 2530 0.266373241695852 807 6152314
SGTC_3256 9138902 49.47 µM -0.624232672505465 0.251104586129073 no 2531 0.266237396348182 827 17228773
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.624344234410212 0.25106647715528 no 2532 0.266200769809938 791 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3020 9089140 49.47 µM -0.624535797531359 0.251001047315348 no 2533 0.266137884275021 806 17217859
SGTC_2015 5119600 184 µM -0.627001328618847 0.25015973245539 no 2534 0.265329182123949 824 2828786
SGTC_1184 1269-1718 139 µM -0.627470872839949 0.249999679274407 no 2535 0.265175311617718 799 5403821
SGTC_2227 7312221 64.1025 µM -0.627900248352631 0.249853365948411 no 2536 0.265034644147522 821 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2008 4012253 172 µM -0.62862405671227 0.249606825084821 no 2537 0.264797603544283 805 603940
SGTC_1068 loratadine 26.9 µM -0.63042337181934 0.248994509541724 no 2538 0.264208811705032 823 3957 A H1 histamine antagonist.
SGTC_374 0880-0231 82.3 µM -0.630584091678822 0.248939854716581 no 2539 0.264156251628278 809 6833587
SGTC_2693 st077581 40.7 µM -0.631354195950928 0.24867805961413 no 2540 0.263904479016563 815 25238761
SGTC_2889 9059656 51.95 µM -0.631413711278888 0.248657833626479 no 2541 0.263885026576595 824 3949838
SGTC_195 4234-0266 16.654 µM -0.631525922017976 0.248619701749355 no 2542 0.263848352758242 812 2303354
SGTC_2681 menadione 3.18 µM -0.631885435844899 0.248497551382726 no 2543 0.26373087041299 821 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_157 1348-1695 65.819 µM -0.632128511518973 0.248414980797801 no 2544 0.263651452982739 800 5380510
SGTC_2802 7925815 54.55 µM -0.632154578555831 0.248406126931849 no 2545 0.263642937112064 806 1262923
SGTC_77 0828-0286 12.516 µM -0.632869431756358 0.248163387207875 no 2546 0.263409455589065 797 745345
SGTC_379 3970-0972 5.9 µM -0.632945189328657 0.24813766994061 no 2547 0.263384718244228 811 2898042 YBL034C STU1
SGTC_2694 st077685 81.9 µM -0.633077046535409 0.248092912036271 no 2548 0.263341665348252 780 2838096
SGTC_399 oxolinic acid 75 µM -0.63370637936136 0.247879349241589 no 2549 0.263136230451891 793 4628 A DNA gyrase inhibitor.
SGTC_903 1134-0042 114 µM -0.634263908124647 0.247690235009795 no 2550 0.262954303185288 816 701009
SGTC_1617 st002906 78 µM -0.635118480268398 0.247400513041741 no 2551 0.262675572530738 805 5150859
SGTC_1221 2958-7315 257 µM -0.635339178204465 0.247325720195896 no 2552 0.262603613380925 807 4562705
SGTC_133 0724-0033 378.92 µM -0.635407876547825 0.247302441318832 no 2553 0.262581216162094 801 280309
SGTC_566 0958-0068 16.5 µM -0.637225598146747 0.246686920385031 no 2554 0.261988953029504 825 6815365
SGTC_2655 perillic acid 100 µM -0.637240475935276 0.246681885822336 no 2555 0.26198410826861 816 5702197 An apoptosis inducer.
SGTC_859 0439-0102 54.6 µM -0.638370777748119 0.246299558775455 no 2556 0.261616174335133 819 610143
SGTC_1825 st052143 62.6 µM -0.639632306108416 0.245873219471882 no 2557 0.261205837163528 810 674173
SGTC_303 1348-1668 34.2 µM -0.639666735327933 0.24586158951402 no 2558 0.261194643013527 820 5380509
SGTC_150 3970-0969 77.2 µM -0.64030121835943 0.24564731829761 no 2559 0.260988394409824 831 6615640
SGTC_639 0833-0042 114 µM -0.640875136388149 0.245453586901915 no 2560 0.260801905563657 829 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_413 propylparaben 100 µM -0.64263057260751 0.24486153293229 no 2561 0.260231920195155 807 7175 A pharmaceutical preservative.
SGTC_2264 7948757 110.76 µM -0.642649577111289 0.244855127513142 no 2562 0.260225752998856 809 2971411
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.645599571848998 0.243861933725227 no 2563 0.259269357349671 848 5393153
SGTC_2043 5101342 149 µM -0.646141859937815 0.243679594942325 no 2564 0.25909374406028 825 678451
SGTC_2666 tannic acid 100 µM -0.646492192272107 0.243561838454114 no 2565 0.258980325976764 821 16134267 A thiamine antagonist.
SGTC_638 3970-0837 4.09 µM -0.649770851413528 0.242461280725051 no 2566 0.257920124976847 811 4118451 YLR208W SEC13
SGTC_3150 9097574 49.47 µM -0.650283200692189 0.242289542548945 no 2567 0.257754653229306 806 17217476
SGTC_369 0957-0393 4.5 µM -0.651686428570056 0.241819521852224 no 2568 0.257301739667787 824 6997992
SGTC_540 1187-0821 17.3 µM -0.652229097585903 0.241637883943212 no 2569 0.257126695805499 827 847520
SGTC_3346 9158254 43.5805 µM -0.653040860639095 0.241366315319481 no 2570 0.256864968345269 838 17639500
SGTC_56 0957-0365 83.25 µM -0.655457142746328 0.240558950370924 no 2571 0.256086735498719 799 6752360
SGTC_1712 st032288 53.4 µM -0.657893742665344 0.239746287804697 no 2572 0.255303205868966 813 2883011
SGTC_244 nsc-207895 1.295 µM -0.658800957224114 0.23944409386102 no 2573 0.255011796276536 794 42640
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.659753257286272 0.239127105798968 no 2574 0.254706091923053 830 16725076
SGTC_894 0960-0238 55.9 µM -0.660751868116957 0.23879494897546 no 2575 0.254385727277638 832 6741907 YDL195W SEC31
SGTC_57 miconazole 162.5 nM -0.661109643838399 0.238676007451469 no 2576 0.25427100054699 815 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2102 5377816 72.7585 µM -0.662602614136579 0.238180023777469 no 2577 0.253792547753824 815 1379702
SGTC_274 sirtinol 40.1 µM -0.663994419079738 0.237718157606816 no 2578 0.253346941526098 803 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1967 st070177 51.4 µM -0.66541305912787 0.237247892360564 no 2579 0.252893167257477 831 5729214
SGTC_3279 9140807 49.47 µM -0.66560963718669 0.237182768996373 no 2580 0.252830322445409 832 45595718
SGTC_824 1304-0008 100 µM -0.666130857340581 0.237010144120739 no 2581 0.252663731333213 819 768245
SGTC_460 trequinsin 123 µM -0.668141411546724 0.236344908414657 no 2582 0.25202166491732 844 5537 A vasodilator.
SGTC_2409 alverine citrate 63.97 µM -0.668489157423333 0.236229953474666 no 2583 0.251910700367683 791 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2211 7117706 200 µM -0.668634016776088 0.23618207616129 no 2584 0.251864483840788 812 822771
SGTC_1552 6-methylflavone 10.6 µM -0.668942857474781 0.236080019390998 no 2585 0.251765964972749 832 689013
SGTC_2242 6630449 61.2675 µM -0.66894687854414 0.236078690784171 no 2586 0.251764682402943 804 691249 YDR170C SEC7
SGTC_882 0843-0131 351 µM -0.668953717944417 0.236076430978371 no 2587 0.251762500899559 821 5425421
SGTC_1217 1183-1422 255 µM -0.669012452385878 0.236057025026033 no 2588 0.251743767301969 815 2849664
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.670279941263275 0.235638458905115 no 2589 0.251339675786555 834 6708784 An antioxidant flavonoid
SGTC_1065 prochlorperazine maleate 2.48 µM -0.672610714010144 0.234869831474824 no 2590 0.250597491875456 848 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1992 st073643 23.3 µM -0.673238408581126 0.234663071432845 no 2591 0.250397814803491 832 3161292
SGTC_391 gliotoxin 8.33 µM -0.673826645839992 0.234469399863007 no 2592 0.250210766143979 837 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2811 7967822 32.47 µM -0.673914298384095 0.234440548661823 no 2593 0.250182900587352 816 2232244
SGTC_276 colchicine 750 µM -0.674439691357732 0.234267654549093 no 2594 0.250015907794632 837 2833 A microtubule depolymerizer.
SGTC_1708 st033234 31.827 µM -0.674633410494094 0.234203924083478 no 2595 0.249954350334726 804 674664
SGTC_2010 4012422 159 µM -0.675027201462477 0.234074402810883 no 2596 0.249829241539101 822 952393
SGTC_3356 9151811 4.48 µM -0.67534172286831 0.233970982488279 no 2597 0.249729340851107 843 1859254 YPR165W RHO1
SGTC_2580 diallyl disulphide 81.36 µM -0.675832087583432 0.233809792216971 no 2598 0.249573629799118 819 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1 0258-0098 57.368 µM -0.676573619681629 0.233566156386285 no 2599 0.249338260738357 802 6790032 YDR047W HEM12
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.680787427665546 0.232184355262879 no 2600 0.248003003195506 831 1377
SGTC_1661 st013063 9.66 µM -0.680911580445012 0.232143711926722 no 2601 0.247963720019234 846 721395
SGTC_2823 7987624 58.44 µM -0.681042616751355 0.232100819456982 no 2602 0.24792226242851 850 2239440
SGTC_1150 3909-7983 10.9 µM -0.681938594183117 0.231807654970887 no 2603 0.247638890023568 835 23965914
SGTC_2206 7254556 146.969 µM -0.682654737991213 0.231573480587499 no 2604 0.24741251838182 812 4398905
SGTC_2856 9022925 19.48 µM -0.683293756512928 0.231364637045896 no 2605 0.247210619298319 815 4944862
SGTC_2128 5255449 168.493 µM -0.683745453835955 0.23121707706287 no 2606 0.247067957860828 819 736008
SGTC_1289 0976-0073 69.1 µM -0.684220576092698 0.231061921325054 no 2607 0.246917945569497 833 3391136
SGTC_61 0978-8327 98.565 µM -0.684256214124924 0.23105028572653 no 2608 0.246906695393591 840 6150059 YHR072W ERG7
SGTC_2701 st077767 14.721 µM -0.684427478666036 0.230994373468727 no 2609 0.246852634613549 818 5721188
SGTC_2395 5646831 180.19 µM -0.684813408350482 0.230868407770199 no 2610 0.246730836596363 842 6808628
SGTC_929 2805-0021 398 µM -0.684895159528055 0.230841729480737 no 2611 0.246705040350149 859 3098024
SGTC_2388 9080168 200 µM -0.685013985903092 0.230802955318102 no 2612 0.246667547753997 845 15943073
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.685136293860101 0.230763048881691 no 2613 0.246628959821623 829 140250 A respiratory chain inhibitor.
SGTC_2320 7373003 200 µM -0.685159435964548 0.230755498548037 no 2614 0.246621658894596 817 5415828
SGTC_2122 5258151 111.688 µM -0.685803861685978 0.230545303901826 no 2615 0.246418400412882 829 2173356
SGTC_1254 0550-0035 264 µM -0.686477809111354 0.230325594571658 no 2616 0.246205926559527 834 15121435
SGTC_2433 5607874 27.82 µM -0.687150796019123 0.230106315255321 no 2617 0.245993853594601 832 2252428
SGTC_2789 5281112 71.43 µM -0.687432466805713 0.230014573150944 no 2618 0.245905122043017 826 765948
SGTC_1972 st070201 17.4 µM -0.689522260185783 0.22933455280864 no 2619 0.245247334951449 826 2829099
SGTC_302 1094-0063 18.9 µM -0.689586924462381 0.229313528995991 no 2620 0.245226996208055 830 5440289
SGTC_120 rhodamine 6G 52.259 µM -0.690633228837041 0.228973502101477 no 2621 0.244898029986512 854 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_530 4358-1714 28 µM -0.691436450028503 0.228712664189338 no 2622 0.244645652227068 827 1564641
SGTC_1710 st031758 61.5 µM -0.692109238410656 0.228494311462333 no 2623 0.24443436521339 829 5394341
SGTC_3322 9139058 2.11 µM -0.696334206484918 0.227125782774359 no 2624 0.243109777983998 820 4908926 YPR165W RHO1
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.696374408604555 0.227112782953475 no 2625 0.243097192720983 831 2724 A muscle relaxant with antifungal properties.
SGTC_3330 9141424 71.43 µM -0.69688123226533 0.226948931635708 no 2626 0.242938561929618 823 27261020
SGTC_1812 st052057 4.327 µM -0.697203577833479 0.226844755042705 no 2627 0.24283770009861 828 3645418
SGTC_538 2922-0838 53.3 µM -0.698672142300368 0.226370481601036 no 2628 0.242378473649333 831 777039
SGTC_2815 7968870 71.43 µM -0.701799494932251 0.225362370410014 no 2629 0.241402106904099 841 2977326 YHR190W ERG9
SGTC_2153 5569715 200 µM -0.70301536455334 0.224971118640566 no 2630 0.241023087207296 829 2054701
SGTC_637 1181-0519 7.26 µM -0.70357254906574 0.224791952285382 no 2631 0.240849505797246 840 6252091 YGR060W ERG25
SGTC_395 anisomycin 6.25 µM -0.705513012385745 0.224168615428409 no 2632 0.2402455184973 850 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1097 itavastatin 7.23 µM -0.705669067040207 0.224118528526067 no 2633 0.24019698091437 831 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1206 3978-0017 132 µM -0.706418236600198 0.223878165502787 no 2634 0.23996404159782 832 3873677
SGTC_472 calcifediol 10 µM -0.70660631574605 0.22381784533911 no 2635 0.239905581494287 847 5283731 A vitamin D metabolite.
SGTC_3164 9100705 49.47 µM -0.706908349834629 0.223720997228971 no 2636 0.239811717357045 811 17174235
SGTC_1647 st011722 22.4 µM -0.707474815138872 0.22353942273994 no 2637 0.239635729090454 834 2854783
SGTC_1137 ixabepilone 100 µM -0.707499886742288 0.223531388238945 no 2638 0.239627941526016 839 154225 A novel microtubule stabilizer.
SGTC_2534 helenine 20.12 µM -0.707501949153553 0.223530727321421 no 2639 0.23962730092054 826 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1039 k821-0043 94 µM -0.707571782721761 0.223508349206638 no 2640 0.23960561047052 819 15992768
SGTC_557 1315-0110 16.2 µM -0.707863722069619 0.223414811261231 no 2641 0.239514945114273 829 6833801
SGTC_3113 9123498 49.47 µM -0.708243664356221 0.223293110361266 no 2642 0.239396977419793 862 8897275
SGTC_3333 9141820 12.094 µM -0.708363689326753 0.223254672505471 no 2643 0.239359717648535 833 1939433
SGTC_2955 9076254 12.21 µM -0.708426461646876 0.22323457124369 no 2644 0.239340232279284 821 16459619
SGTC_2338 7999974 200 µM -0.710470744604405 0.222580504200379 no 2645 0.238706133278409 850 315925
SGTC_1524 corynanthine 62.1 µM -0.711822310874273 0.222148672072909 no 2646 0.238287407543054 863 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2166 5933061 31.504 µM -0.712448467075247 0.221948774250377 no 2647 0.238093555943628 850 2877375
SGTC_2628 lathosterol 100 µM -0.712899139721573 0.221804962429299 no 2648 0.237954085776326 824 6710616
SGTC_881 0833-0569 170 µM -0.714025113045338 0.221445891612009 no 2649 0.237605825383493 840 5418700
SGTC_1958 st076513 41.9 µM -0.714293000560016 0.221360511742868 no 2650 0.237523009733163 850 732122 YGL099W LSG1
SGTC_779 1360-0071 233 µM -0.715924543050353 0.220840920691724 no 2651 0.237018971414506 831 7566
SGTC_1288 0973-0013 65.5 µM -0.715940214024714 0.22083593340513 no 2652 0.237014132975661 838 4315430
SGTC_2271 7849410 118.62 µM -0.717430433060958 0.220361966025116 no 2653 0.236554273531037 862 972430
SGTC_680 0417-1641 114 µM -0.717678197674435 0.220283220528928 no 2654 0.236477864681275 833 2835990
SGTC_979 1426-2828 121 µM -0.717956669840724 0.220194734701036 no 2655 0.236392002055534 834 747872
SGTC_82 0054-0107 293.755 µM -0.718750052756064 0.219942745379009 no 2656 0.236147468717223 835 3104697
SGTC_1264 0783-0040 158 µM -0.719532480879624 0.219694397593693 no 2657 0.235906448351022 839 2855798
SGTC_20 0481-0013 4.944 µM -0.72055569180298 0.219369866864205 no 2658 0.235591461583984 838 182045
SGTC_2059 5238311 157 µM -0.720652748155912 0.21933909791384 no 2659 0.235561595664505 846 703021
SGTC_2031 5180455 200 µM -0.721587318091859 0.219042946098085 no 2660 0.23527411923856 856 29949
SGTC_268 camptothecin 39.6153 µM -0.721656902163148 0.21902090510532 no 2661 0.235252722726688 863 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1715 st032160 10.2275 µM -0.722960404200744 0.218608252183568 no 2662 0.234852105536165 818 5289825
SGTC_1268 0828-0275 2.46 µM -0.723206144805786 0.21853050763555 no 2663 0.234776622097013 850 745337
SGTC_2464 5717415 7.67 µM -0.723238735964928 0.218520198020369 no 2664 0.234766612171247 837 5285744
SGTC_1449 4112-4002 201 µM -0.724321013846794 0.218177998373959 no 2665 0.234434339464119 858 2059539
SGTC_2000 st075254 36.4 µM -0.726347091570022 0.217538214611746 no 2666 0.233813008627222 823 17234175
SGTC_1928 4'-methoxychalcone 40.3 µM -0.727314732625858 0.217233040679773 no 2667 0.233516587529904 841 641818
SGTC_831 k061-1017 217 µM -0.728035538363345 0.217005874286807 no 2668 0.233295915941415 861 1240153
SGTC_2526 patulin 37.61 µM -0.72825031318174 0.216938213229558 no 2669 0.233230185935735 848 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_3222 9128301 49.47 µM -0.728577410205308 0.216835190453143 no 2670 0.233130100425516 828 4911358
SGTC_1968 st069590 43.6 µM -0.729136735363735 0.216659090446495 no 2671 0.232959012753456 855 6384066
SGTC_2726 cimetidine 79.27 µM -0.729328503067959 0.216598732639518 no 2672 0.232900370462479 850 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_864 0469-0573 172 µM -0.731401044521177 0.215947032786313 no 2673 0.232267113730127 871 689425
SGTC_751 0833-0568 350 µM -0.731977778203802 0.215765884149089 no 2674 0.232091065609958 852 6954252
SGTC_2719 novobiocin 32.65 µM -0.735200780786279 0.214755180919796 no 2675 0.231108611795471 857 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1344 1488-0097 29.1 µM -0.735500486116045 0.214661336154374 no 2676 0.231017372019152 860 747966
SGTC_1885 st057546 99.9 µM -0.735782036149549 0.214573197953089 no 2677 0.230931677608509 835 702008
SGTC_141 0443-0274 32.331 µM -0.736076792128009 0.214480948222897 no 2678 0.230841982769058 810 1627241
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.73691928747969 0.21421739977557 no 2679 0.230585717038307 845 641818 YHR062C RPP1
SGTC_1207 2099-0101 141 µM -0.737338859891561 0.214086219915628 no 2680 0.230458153069677 846 5837381
SGTC_1258 0671-0043 57.1 µM -0.737964913438158 0.213890570406681 no 2681 0.230267885334735 867 4298767
SGTC_2194 5927483 104.545 µM -0.738881170700802 0.213604416388453 no 2682 0.22998957846969 812 760979
SGTC_690 glyoxal 20.3 µM -0.740090717815422 0.213227007531895 no 2683 0.229622475275582 847 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1977 st070720 65.3 µM -0.740098947731953 0.213224440925413 no 2684 0.229619978582326 834 682188
SGTC_1969 st069479 40.1 µM -0.74049037089562 0.213102391328982 no 2685 0.229501250885701 859 3895485
SGTC_1605 st000082 49.1 µM -0.740535969079907 0.213088176016829 no 2686 0.229487422139457 842 1114022
SGTC_261 5-fluorouridine 15.376 µM -0.741544776320322 0.212773820151892 no 2687 0.229181596543208 833 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_769 0302-0231 76 µM -0.741678672074323 0.212732117065534 no 2688 0.229141022479656 861 571869 YER009W NTF2
SGTC_417 st075190 100 µM -0.741932171121428 0.212653175485041 no 2689 0.229064216393188 856 222757
SGTC_3266 9136860 49.47 µM -0.742822153629259 0.212376163476569 no 2690 0.228794680562281 842 4871271 YPR165W RHO1
SGTC_206 4546-0025 72.014 µM -0.74326725913189 0.212237701046917 no 2691 0.228659944861987 853 6620745 YIL048W NEO1
SGTC_770 0389-1121 67.2 µM -0.744393252297305 0.21188766527032 no 2692 0.228319300005692 848 6753108
SGTC_957 1187-1561 14.1 µM -0.746597778440572 0.211203326319523 no 2693 0.227653194910357 849 1538454
SGTC_2732 terfenadine 20 µM -0.747449356037293 0.210939322909971 no 2694 0.227396181060528 866 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_913 3487-1245 167 µM -0.747553402790816 0.210907079932138 no 2695 0.22736479001551 847 4016153
SGTC_2346 9031566 143.75 µM -0.748810379819561 0.210517784569229 no 2696 0.226985751319435 849 4771086
SGTC_2919 7978188 46.38 µM -0.750524831131657 0.209987486382174 no 2697 0.226469337186095 832 2980291
SGTC_1784 st039334 36.3 µM -0.750792402021673 0.20990479470619 no 2698 0.226388801384425 880 3496984
SGTC_3236 9132701 49.47 µM -0.753591540935743 0.209040880410497 no 2699 0.225547262633628 858 24282524
SGTC_1606 st000094 49.2 µM -0.755265206667641 0.208525329219844 no 2700 0.225044935343427 840 1242210
SGTC_947 3447-0010 211 µM -0.757146007659487 0.207946868237594 no 2701 0.224481196574738 867 748350
SGTC_1688 st021091 57.6 µM -0.759775011553243 0.207139878986501 no 2702 0.223694541024681 872 3656366
SGTC_1266 0828-0227 32.9 µM -0.761821089126888 0.206513106462443 no 2703 0.223083395920598 876 3913820
SGTC_3241 9133421 49.47 µM -0.761828759406296 0.20651075895051 no 2704 0.223081106666822 891 17018221
SGTC_1820 st053765 18.6 µM -0.762793220967651 0.206215708585137 no 2705 0.222793362318698 851 3690829
SGTC_3001 9076041 71.4286 µM -0.763196341874281 0.206092458972129 no 2706 0.222673155051543 847 16004211
SGTC_525 k781-2675 26.7 µM -0.764302000775872 0.205754640660024 no 2707 0.222343646675365 840 3651118 YDL195W SEC31
SGTC_2836 9010338 19.48 µM -0.764496865373896 0.205695136638961 no 2708 0.222285601989041 862 2994051
SGTC_734 2023-0417 80 µM -0.764724093742056 0.205625762889317 no 2709 0.222217927965138 864 3935732
SGTC_2445 5742597 35.57 µM -0.765664600176759 0.20533877017468 no 2710 0.221937947803962 863 1774255
SGTC_3297 9117502 71.43 µM -0.767154010167616 0.204884768237221 no 2711 0.221494976426015 838 7453720
SGTC_85 0868-0259 160.055 µM -0.768283428134957 0.204540897304471 no 2712 0.22115940892382 831 83173
SGTC_2540 epiandrosterone 100 µM -0.768463829587347 0.204486002773945 no 2713 0.221105835822128 868 441302 A steroid.
SGTC_573 3702-0553 84.7 µM -0.769025290424153 0.204315211437396 no 2714 0.220939148558073 858 1222756
SGTC_742 0kpi-0133 140 µM -0.771336179717318 0.20361315436811 no 2715 0.220253846364991 869 2728852
SGTC_2413 inermin 26.06 µM -0.772131376050758 0.203371903740051 no 2716 0.220018310313025 878 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2094 5332512 191.667 µM -0.772941998752415 0.203126148617061 no 2717 0.219778353800561 862 755774
SGTC_1342 1486-1464 234 µM -0.774501816036665 0.202653760520617 no 2718 0.219317047338415 858 3253938
SGTC_3102 9121669 49.47 µM -0.774868272756017 0.202542875024469 no 2719 0.219208750774276 877 41905072
SGTC_1527 coumarin 137 µM -0.775261936709237 0.202423797357187 no 2720 0.219092448089907 886 323 A hepatotoxic, DNA x-linker.
SGTC_1758 st042942 75.2445 µM -0.775418342948141 0.202376498348357 no 2721 0.219046249835305 865 669317
SGTC_2267 7931562 200 µM -0.775869529126259 0.202240091602474 no 2722 0.218913012798737 850 934880
SGTC_2350 9023895 38.85 µM -0.778362337306141 0.201487434880762 no 2723 0.218177717699288 853 2997209
SGTC_380 3970-0968 6 µM -0.780838633367145 0.20074142800521 no 2724 0.217448704303676 855 2891601
SGTC_2896 9052656 71.43 µM -0.78126541573982 0.2006130236008 no 2725 0.217323203200504 853 6469436
SGTC_2603 homopterocarpin 100 µM -0.781656919996079 0.200495276569286 no 2726 0.217208112896444 869 101795 A weak amylase inhibitor.
SGTC_2253 7938677 135.83 µM -0.783356203778539 0.199984688968944 no 2727 0.216708983538113 874 2301972
SGTC_2575 plumbagin 510 nM -0.783524205376739 0.199934251655896 no 2728 0.21665967261199 851 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3343 9148379 18.9835 µM -0.784220761075053 0.199725213847349 no 2729 0.216455292575871 837 1955036
SGTC_237 nikkomycin 200 µM -0.786494648961058 0.199043731162678 no 2730 0.215788876381145 887 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_815 1582-0027 36.9 µM -0.786556733440212 0.199025144156044 no 2731 0.21577069776148 885 3128206
SGTC_162 k030-0015 37.8 µM -0.786741532919849 0.19896982461565 no 2732 0.215716592881741 888 1809920 YMR134W ERG29
SGTC_2011 4012611 177 µM -0.786786384388769 0.198956399770559 no 2733 0.215703462627609 869 2049887
SGTC_479 n-linoleoylglycine 10 µM -0.787665417952995 0.198693399539806 no 2734 0.215446219354193 872 6433346 An anti-infammatory.
SGTC_934 2950-0684 338 µM -0.787873459110153 0.198631185883181 no 2735 0.215385363558951 869 1121253
SGTC_448 monastrol 171 µM -0.788089535703279 0.198566581709173 no 2736 0.215322167812964 875 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1512 0259-0544 12.2 µM -0.788657583551371 0.198396803039386 no 2737 0.215156082650828 862 18476
SGTC_2788 5282734 71.43 µM -0.790547440726933 0.197832591549275 no 2738 0.214604063972152 867 743706
SGTC_3263 9137018 49.47 µM -0.790638415220859 0.197805455851025 no 2739 0.214577511521187 875 43844957
SGTC_2432 5630864 12.22 µM -0.791989831442565 0.197402622887612 no 2740 0.214183302692027 883 5714970
SGTC_251 melphalan 456.522 µM -0.79226993653142 0.197319190692684 no 2741 0.214101648640478 866 460612 A DNA alkylator.
SGTC_345 1362-0200 395 µM -0.792731770219593 0.197181675340241 no 2742 0.213967058050177 876 1419823
SGTC_2636 apigenin dimethyl ether 100 µM -0.794397091498032 0.196686291887045 no 2743 0.213482148434146 874 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2582 agaric acid 100 µM -0.79483394894326 0.196556464736709 no 2744 0.213355050047954 852 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1755 st041960 45.185 µM -0.79592768220825 0.196231652241888 no 2745 0.213037035139197 881 2257073
SGTC_852 0418-0143 439 µM -0.79642740843564 0.196083353943832 no 2746 0.212891826365657 860 5369229
SGTC_891 0929-0073 133 µM -0.796602501357383 0.196031409613744 no 2747 0.212840962119482 884 5603632
SGTC_2224 6650123 117.647 µM -0.797325598480505 0.195816978832079 no 2748 0.212630978577306 871 2908370
SGTC_2161 5662504 8.5105 µM -0.79845294450532 0.195482954188722 no 2749 0.212303844764239 854 2859334
SGTC_347 4534-1311 26.2 µM -0.798770945794246 0.195388795268476 no 2750 0.212211620212606 873 2862016
SGTC_335 4077-0256 27.6 µM -0.798785169290595 0.195384584391423 no 2751 0.212207495759034 866 3121989
SGTC_2333 9017922 200 µM -0.799341014113135 0.195220069278432 no 2752 0.212046351544092 877 3163164
SGTC_3275 9138069 49.47 µM -0.800353168270342 0.194920715160495 no 2753 0.21175310317258 871 17617007
SGTC_1636 st007707 68.9 µM -0.804717862764583 0.193633015956462 no 2754 0.21049125461575 889 403051
SGTC_1461 k072-0203 53.8 µM -0.806372138221112 0.193146320177216 no 2755 0.21001415349854 865 5418714
SGTC_2260 7964312 200 µM -0.806854263411618 0.193004617291 no 2756 0.209875225910614 859 231951
SGTC_775 4577-0580 57.3 µM -0.80717821928512 0.192909438101166 no 2757 0.209781906216252 876 2006902
SGTC_1037 k284-1091 78.7 µM -0.807784154707036 0.192731489465548 no 2758 0.209607424153572 867 3334711
SGTC_1244 0416-0015 52.5 µM -0.807852178478882 0.192711518786312 no 2759 0.209587841706614 872 96201
SGTC_2892 9047358 58.44 µM -0.808429523334346 0.192542070588718 no 2760 0.209421681004966 865 6466771
SGTC_1129 3453-1384 223 µM -0.809687961683523 0.192173040163583 no 2761 0.209059769310033 897 1084452
SGTC_146 3448-8650 53.125 µM -0.810618409823684 0.191900469571933 no 2762 0.208792420635541 913 2891488 YIL048W NEO1
SGTC_1015 4130-4525 82 µM -0.812283005684809 0.191413424485785 no 2763 0.208314629850392 884 1363237
SGTC_2674 ligustilide 100 µM -0.813568284936521 0.191037882591991 no 2764 0.207946156392621 866 5319022 A signalling regulator.
SGTC_2622 2-methoxyxanthone 59.94 µM -0.813641171416849 0.191016599657229 no 2765 0.207925272288387 874 71034 A hepatoprotective.
SGTC_2973 9094665 17.96 µM -0.813779748184092 0.190976139095295 no 2766 0.207885569415161 863 25237061 YIL048W NEO1
SGTC_3035 9091303 49.47 µM -0.815026775452712 0.190612278352695 no 2767 0.207528491887912 882 25237002
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.816327469243369 0.190233212414679 no 2768 0.207156433817461 873 5024745
SGTC_1685 st024049 53.0905 µM -0.816603935148741 0.190152700668365 no 2769 0.207077402764571 874 1941139
SGTC_2553 4-methylesculetin 85.09 µM -0.817124300177465 0.19000121800007 no 2770 0.206928698651498 867 5319502
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.817987269039835 0.189750164017411 no 2771 0.206682228391827 871 15053
SGTC_1659 st012954 42.1 µM -0.818227674886155 0.18968026175414 no 2772 0.20661359768406 875 24207262
SGTC_1602 st001878 87.6 µM -0.818435666125276 0.189619797394566 no 2773 0.206554231542056 876 595405 YLR310C CDC25
SGTC_912 3474-0017 2.18 µM -0.820022497686682 0.189158885900327 no 2774 0.206101640986278 875 3360550
SGTC_324 1315-0088 19.6 µM -0.822523362202305 0.188433886022735 no 2775 0.205389547982214 904 6787421
SGTC_3003 9075612 71.4286 µM -0.823233626920063 0.188228293389321 no 2776 0.205187574847102 896 6501993
SGTC_832 4083-0019 164 µM -0.824097802014345 0.187978336713721 no 2777 0.204941994479676 887 1990758
SGTC_505 gw-5074 63.9 µM -0.825336089262147 0.187620528067319 no 2778 0.20459040407388 894 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2078 5212016 200 µM -0.825740659109693 0.187503717056583 no 2779 0.204475611240051 864 1899708
SGTC_562 3772-2733 112 µM -0.826930224989673 0.1871605154336 no 2780 0.204138305408947 871 2876874 YIL048W NEO1
SGTC_2104 5389443 200 µM -0.829642723613818 0.186379386673005 no 2781 0.203370406865591 896 2244536
SGTC_1692 fluoroquinolonic acid 71 µM -0.831142482533536 0.185948363590155 no 2782 0.202946571473324 883 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_186 3455-3465 67.277 µM -0.831585543518388 0.185821148477121 no 2783 0.202821462414554 868 755278
SGTC_2605 digitonin 300 nM -0.831601547328785 0.185816554349069 no 2784 0.202816944211329 869 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_681 1642-0006 26.6 µM -0.833195297901135 0.185359397798066 no 2785 0.202367297029289 913 4446530
SGTC_2956 9076196 2.52 µM -0.833665483986475 0.18522466160773 no 2786 0.202234756709649 898 16423868
SGTC_2698 st077697 67.5 µM -0.834249850837788 0.18505729065252 no 2787 0.202070102475819 886 3154499
SGTC_405 ebelactone b 50 µM -0.835024410087329 0.184835590748962 no 2788 0.20185198232822 882 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3309 9129340 25.759 µM -0.835483691788836 0.18470420984285 no 2789 0.201722712676005 874 17158987
SGTC_836 0330-0104 1.35 µM -0.835975634887607 0.184563550319883 no 2790 0.201584305140975 853 46494820
SGTC_972 1319-0219 195 µM -0.837974798555408 0.183992622333978 no 2791 0.201022428758208 882 23903702
SGTC_86 0417-1630 471.922 µM -0.838808186507307 0.183754945665674 no 2792 0.2007884780199 874 3634867
SGTC_1055 3448-0672 86 µM -0.840315318590379 0.183325607647269 no 2793 0.200365807352458 874 748378
SGTC_1643 st009866 20.2 µM -0.840563813260763 0.183254878870056 no 2794 0.200296169134013 853 3156273 YOR207C RET1
SGTC_2371 9071574 200 µM -0.841814962132541 0.182899024275044 no 2795 0.199945767802042 900 45596039
SGTC_2678 equilin 100 µM -0.843068527784702 0.182542915121687 no 2796 0.199595059548177 845 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2646 retinol 96.75 µM -0.843662474260867 0.182374339897002 no 2797 0.199429021330931 866 445354 A vitamin A analog and teratogen.
SGTC_2731 amoxapine 43.43 µM -0.844392441185864 0.18216729231745 no 2798 0.199225072423113 919 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1880 MG-132 525 µM -0.845096011794321 0.181967870892245 no 2799 0.199028617443102 878 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1050 3232-1156 69.3 µM -0.845884138156623 0.181744644996797 no 2800 0.198808690995531 891 700529
SGTC_2772 vinpocetine 57.06 µM -0.846031655784332 0.181702881710565 no 2801 0.198767542524793 897 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_543 3844-1095 191 µM -0.846111226482676 0.181680357174857 no 2802 0.198745349258143 894 4230703
SGTC_531 3788-1495 174 µM -0.847334456068818 0.181334310431667 no 2803 0.198404363229066 859 2896655
SGTC_3026 9090633 49.47 µM -0.850884590405683 0.18033233075967 no 2804 0.197416732815752 878 25236842
SGTC_1815 st051655 58.2 µM -0.854823427135221 0.179224718787351 no 2805 0.19632445337379 889 5984156
SGTC_2808 7946468 45.46 µM -0.855597849619318 0.179007453377435 no 2806 0.196110129904648 909 2970879
SGTC_3109 9122853 49.47 µM -0.856439030721808 0.178771646590683 no 2807 0.195877491659154 927 1234709
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.859708479686062 0.177856986107281 no 2808 0.194974879641411 886 2374 Ca(2+)-ATPase inhibitor.
SGTC_397 arbidol 50 µM -0.859758055813943 0.177843139455186 no 2809 0.19496121242167 886 131410 A RNA synthesis inhibitor.
SGTC_892 0929-0076 29 µM -0.860783063805049 0.177557006277673 no 2810 0.194678767256791 892 5751038
SGTC_311 1315-0136 58 µM -0.861047901162524 0.177483123621238 no 2811 0.194605830725818 884 6759207
SGTC_2449 5812982 45.77 µM -0.861281987320245 0.177417835899824 no 2812 0.194541376958657 903 776185
SGTC_658 3253-0951 102 µM -0.863031900431233 0.176930257390157 no 2813 0.194059963948367 905 1184878
SGTC_2558 carylophyllene oxide 100 µM -0.863711089051728 0.176741243309599 no 2814 0.193873310221273 905 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_689 0833-0039 98 µM -0.864174419496075 0.176612374526301 no 2815 0.193746041161616 919 5374726
SGTC_1697 st025554 27.742 µM -0.866790317947968 0.175885914698551 no 2816 0.193028453997243 878 1269519
SGTC_2334 9017922 200 µM -0.869823106152901 0.175046053138646 no 2817 0.192198541081552 894 3163164
SGTC_3233 9132340 49.47 µM -0.871390287018558 0.174613056854508 no 2818 0.19177054369505 922 17682950
SGTC_486 niguldipine 82 µM -0.874516464000902 0.17375135909709 no 2819 0.190918529065425 881 1236 A calcium channel blocker.
SGTC_3045 9092950 49.47 µM -0.875692988262368 0.173427764347207 no 2820 0.190598479094698 879 44120432
SGTC_1222 0366-0074 1.18 µM -0.876459654011774 0.173217104880316 no 2821 0.190390100307109 905 286520
SGTC_1314 1222-0010 41.1 µM -0.876904333968897 0.173094993290043 no 2822 0.190269300990106 904 3526027
SGTC_1953 st076800 12.1 µM -0.877558030807316 0.172915584078295 no 2823 0.190091806798829 884 297591
SGTC_2623 humulene 100 µM -0.878222685601336 0.172733288952377 no 2824 0.189911441628258 907 6187145 An anti-inflammatory.
SGTC_1525 8-methoxypsoralen 92.5 µM -0.879502980523465 0.172382487377507 no 2825 0.189564308885812 915 4114 Related to psoralen; DNA damaging agent.
SGTC_1587 estradiol valerate 56.1 µM -0.879613501958064 0.172352225762067 no 2826 0.189534360974073 904 13791 A steroid.
SGTC_2317 5986382 200 µM -0.88280830822348 0.171478928499507 no 2827 0.188669925407023 929 877883
SGTC_1731 st035964 63 µM -0.887265083764571 0.170265406053654 no 2828 0.187468099676681 932 6739575
SGTC_754 3474-0146 171 µM -0.889640042652941 0.169620988102892 no 2829 0.186829598929994 876 24762078
SGTC_2980 9014342 25.29 µM -0.88988470971681 0.169554689500737 no 2830 0.186763897460851 879 2996599
SGTC_2374 9071832 200 µM -0.88991679988986 0.169545995106844 no 2831 0.186755281213586 878 17381698
SGTC_1100 amiodarone 5.07 µM -0.890947215848897 0.169266970044779 no 2832 0.186478744187819 883 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2826 7992541 19.48 µM -0.89096434074361 0.169262335307407 no 2833 0.186474150451971 942 2985066
SGTC_931 2812-0076 566 µM -0.892616789486957 0.168815494420644 no 2834 0.186031212458307 907 3450959
SGTC_1227 3909-8010 46.6 µM -0.892699776637309 0.168793073760216 no 2835 0.186008985012067 900 15982272
SGTC_1178 0988-0033 191 µM -0.892842360496115 0.168754556309425 no 2836 0.185970798907843 888 5392207
SGTC_1819 st053448 58.6 µM -0.894188499341409 0.168391190224444 no 2837 0.185610522261387 932 2857616
SGTC_29 0299-0004 12.984 µM -0.894415106879052 0.168330071092669 no 2838 0.185549916302424 889 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2717 st081029 62.2815 µM -0.894912219056278 0.16819604317269 no 2839 0.185417007175411 893 5292846
SGTC_88 0180-0332 8.668 µM -0.896221148105297 0.167843467329754 no 2840 0.185067331468843 897 3101745
SGTC_868 0527-0199 213 µM -0.896251275851789 0.167835357663534 no 2841 0.185059287775486 900 2849450
SGTC_1625 st003711 30.1 µM -0.898528473203766 0.167223120996635 no 2842 0.184451936175503 902 24207034 YER133W GLC7
SGTC_265 mycophenolic acid 32.932 µM -0.899322167344825 0.16701007084457 no 2843 0.184240541630214 912 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2528 xanthyletin 44.79 µM -0.899821329703192 0.166876171127788 no 2844 0.184107670699704 920 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2870 9038528 12.99 µM -0.902762007817958 0.166088743846165 no 2845 0.183326109429076 908 6463316
SGTC_2001 4023502 57.655 µM -0.903202141181597 0.165971095920194 no 2846 0.183209310846828 905 108941 YCR052W RSC6
SGTC_3294 9122953 26.2835 µM -0.903447933018251 0.165905419047793 no 2847 0.1831441050489 909 16459826
SGTC_2691 st077356 60.2 µM -0.903558766510888 0.165875809250852 no 2848 0.183114706911343 919 2839272
SGTC_1216 1165-0504 9.65 µM -0.903892653278729 0.165786630150359 no 2849 0.183026162583727 913 6304004
SGTC_2332 7982454 138.89 µM -0.904106682412304 0.165729480591682 no 2850 0.182969417676566 914 2981748
SGTC_469 w7 172 µM -0.904122520163209 0.165725252138676 no 2851 0.182965219097088 890 45115570 A P450 inhibitor.
SGTC_3065 9113888 49.47 µM -0.904599415226219 0.165597960649883 no 2852 0.182838822626581 908 16648368
SGTC_517 1365-0151 113 µM -0.904996465454948 0.165492029369498 no 2853 0.182733629853331 905 768657
SGTC_744 1594-0068 283 µM -0.905674017167404 0.165311362752956 no 2854 0.182554209500623 902 668392
SGTC_1098 clofazimine 15.1 µM -0.90676598608814 0.165020462043971 no 2855 0.182265280262521 920 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2203 7227154 166.4 µM -0.909584774685993 0.164271069335559 no 2856 0.181520765527007 903 896304
SGTC_96 0929-0093 37.281 µM -0.910043882011541 0.16414922206526 no 2857 0.181399683961124 917 6991579
SGTC_1165 k072-0275 30.3 µM -0.914725603359349 0.162910039156219 no 2858 0.180167849849863 904 6153523 YGL055W OLE1
SGTC_1102 cgs 12066b 26.1 µM -0.915626620598913 0.162672252871151 no 2859 0.179931382014836 885 6438352 A 5-HT1B full agonist.
SGTC_2180 6301957 200 µM -0.91792171330125 0.162067578483802 no 2860 0.179329926539448 906 845462
SGTC_823 0417-1665 178 µM -0.917954331249831 0.162058995390901 no 2861 0.179321387751535 932 3429856
SGTC_1436 4092-1007 8.32 µM -0.9181905193431 0.161996853646688 no 2862 0.179259565616628 876 2881121
SGTC_860 0443-0016 25.1 µM -0.919012225079192 0.161780781529655 no 2863 0.179044588934385 900 5337942
SGTC_3070 9117005 49.47 µM -0.919891653613185 0.161549739034461 no 2864 0.178814690451951 929 8779016
SGTC_260 nsc-65238 3.989 µM -0.921031198046999 0.161250679301164 no 2865 0.178517069506302 919 3246252
SGTC_1949 st076024 69.1 µM -0.922452613187205 0.160878152505946 no 2866 0.178146268474694 913 2921930
SGTC_1792 st045773 43.6 µM -0.923682109563178 0.160556377620083 no 2867 0.17782592470651 849 2919270
SGTC_920 mycophenolic acid 780.421 nM -0.923777199331493 0.160531508941471 no 2868 0.177801164331226 917 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1401 3807-4679 7.6 µM -0.926401595283599 0.159846147913401 no 2869 0.177118657685754 905 3291456
SGTC_3192 9110362 49.47 µM -0.926412256385332 0.159843367675844 no 2870 0.177115888513816 943 16649480
SGTC_821 1114-0266 29.2 µM -0.926923014216397 0.159710207610824 no 2871 0.176983253569058 899 3123235
SGTC_282 k297-0036 65.7 µM -0.928357548144075 0.159336597507448 no 2872 0.176611065795122 929 5061378
SGTC_1070 indatraline 8.81 µM -0.928740411459054 0.15923698139174 no 2873 0.176511816193315 911 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2942 9052777 62.25 µM -0.930918843582399 0.158670957802377 no 2874 0.17594777315398 924 6469503
SGTC_976 1348-1067 47.6 µM -0.93334310376503 0.158042613306139 no 2875 0.175321423331956 916 5310671 YGL099W LSG1
SGTC_709 3807-1509 243 µM -0.93337906022338 0.158033306054535 no 2876 0.175312144007687 936 1886677 YPL242C IQG1
SGTC_2998 9066762 71.4286 µM -0.933698667527806 0.157950592208166 no 2877 0.175229676272386 898 4945196
SGTC_361 000s-0510 1.45 µM -0.934418701117481 0.157764352867418 no 2878 0.175043977378031 911 660
SGTC_993 3909-8757 62.7 µM -0.936885290707011 0.157127454180541 no 2879 0.174408783133483 901 4288324 YLR208W SEC13
SGTC_484 loperamide 105 µM -0.938018100357718 0.156835518530516 no 2880 0.174117554144389 878 3955 An opioid-receptor agonist.
SGTC_2629 bisabolol 100 µM -0.938220020276902 0.156783519380525 no 2881 0.174065675928999 907 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2215 7188065 200 µM -0.938271841331642 0.156770176064281 no 2882 0.17405236340452 925 940217
SGTC_2414 st077232 92.9 µM -0.938294417293719 0.156764363251488 no 2883 0.174046563974927 890 729801
SGTC_2991 9074669 71.4286 µM -0.939870171971688 0.156358991605459 no 2884 0.173642079532853 895 17333109
SGTC_2514 salinomycin 42.74 µM -0.940074606758854 0.156306450261715 no 2885 0.173589646517565 919 23682228 A polyether potassium ionophore.
SGTC_675 1309-0189 238 µM -0.940479306998082 0.156202473428333 no 2886 0.173485879545573 909 4246530
SGTC_385 1494-0393 12.4 µM -0.940734427629982 0.156136950472036 no 2887 0.17342048575382 925 3090647
SGTC_650 1328-0195 38 µM -0.940866024551448 0.156103159348619 no 2888 0.173386760310083 923 2780821
SGTC_2170 morpholine 200 µM -0.941304036292444 0.155990722521781 no 2889 0.173274537455815 914 121171 Reacts with secondary amines.
SGTC_2555 cholic acid 100 µM -0.941496320614864 0.155941380345483 no 2890 0.173225286959687 908 6708657 Influences liver metabolism.
SGTC_1933 st074711 15.9 µM -0.942677617955493 0.155638472816633 no 2891 0.172922912528997 899 17250958
SGTC_193 1273-0060 1.558 µM -0.945831627844445 0.154831626062766 no 2892 0.172117235520494 918 2847393 YHR072W ERG7
SGTC_1127 asiatic acid 681.4 nM -0.946629022235353 0.154628078050594 no 2893 0.171913924901843 932 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2873 9040596 71.43 µM -0.94810442610459 0.154251923499185 no 2894 0.171538147615848 918 6463863
SGTC_1454 4239-0054 42.6 µM -0.949625296505247 0.15386481118143 no 2895 0.171151340068122 897 1340767
SGTC_1328 1441-0025 69.2 µM -0.951574349376476 0.153369652897804 no 2896 0.17065644771704 914 4562601
SGTC_2657 nystatin 74.44 µM -0.953974202817264 0.152761420078206 no 2897 0.170048350368304 910 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1432 4049-0298 68.4 µM -0.954579527594436 0.152608256048765 no 2898 0.169895187104911 919 741646
SGTC_1931 st074438 57.1 µM -0.954735318993787 0.152568852976015 no 2899 0.169855782054246 931 2787313
SGTC_568 1193-0097 7.48 µM -0.95696081443559 0.152006713199056 no 2900 0.169293516909782 874 3646150
SGTC_2300 7976697 71.57 µM -0.957376938735093 0.151901756869501 no 2901 0.169188517014846 898 2236109
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.958803100018514 0.151542410804771 no 2902 0.16882897360741 963 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1500 4488-1866 171 µM -0.960081153731476 0.151220863547066 no 2903 0.168507186385064 929 2900003
SGTC_412 gemfibrozil 100 µM -0.960639645011906 0.15108049457383 no 2904 0.168366693840558 900 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2060 5238662 140 µM -0.962487378098283 0.150616710782939 no 2905 0.16790242022335 932 790130
SGTC_2890 9046729 58.44 µM -0.963985109582977 0.150241474421824 no 2906 0.167526695660952 910 903329
SGTC_480 am 92016 50 µM -0.964224127087333 0.150181649517616 no 2907 0.167466785303755 942 2129 K+ channel blocker.
SGTC_2372 9071633 200 µM -0.96598958918847 0.149740254878722 no 2908 0.167024695258841 931 21321366
SGTC_777 1315-0167 517 µM -0.968919291116326 0.149009692579771 no 2909 0.166292729772722 896 4221767
SGTC_1166 k206-0078 225 µM -0.968971689829351 0.148996647936489 no 2910 0.166279657206988 916 5404595
SGTC_215 1287-0124 461.5 µM -0.969723879259492 0.14880947469331 no 2911 0.1660920722033 932 5560863
SGTC_1459 k035-0031 35.7 µM -0.969728790653093 0.148808253068998 no 2912 0.166090847823273 893 3877128 YMR208W ERG12
SGTC_2373 9071805 200 µM -0.971886540661304 0.148272198276293 no 2913 0.16555349817932 947 10149009
SGTC_2484 5809818 12.04 µM -0.971919270255313 0.14826407714672 no 2914 0.165545356116853 915 2870548
SGTC_855 0428-0020 25 µM -0.97353895678251 0.14786255924971 no 2915 0.165142754147596 905 6812414
SGTC_897 1000-0139 31.4 µM -0.975183837156794 0.147455541572119 no 2916 0.164734539009416 928 6151020
SGTC_190 3970-0790 3.722 µM -0.977275562995333 0.14693903940521 no 2917 0.164216373862002 910 2832352
SGTC_3278 9139605 49.47 µM -0.980192056647275 0.146220908018453 no 2918 0.16349566238527 924 7958859
SGTC_1385 3091-4834 14.1 µM -0.981220886735777 0.145968141430767 no 2919 0.163241913161182 912 4072814
SGTC_1565 sinapyl alcohol 95.1 µM -0.981731237836856 0.145842865585601 no 2920 0.163116135876843 919 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1887 st057648 70.8 µM -0.982905625079018 0.145554863368222 no 2921 0.162826944547327 947 688672
SGTC_1867 st057372 64 µM -0.985097733983882 0.145018302804646 no 2922 0.162288033169653 901 688837
SGTC_624 k048-0052 28 µM -0.985759339726818 0.144856624039957 no 2923 0.162125611380289 924 6835531
SGTC_1868 st057644 42.7 µM -0.98650533998772 0.14467446714509 no 2924 0.161942598063371 943 688665
SGTC_739 1486-1183 203 µM -0.988222619851986 0.144255731685906 no 2925 0.161521816228259 924 4346692
SGTC_535 2293-4129 48.2 µM -0.988867298741097 0.144098746590889 no 2926 0.16136403597787 955 396118 YIL048W NEO1
SGTC_1936 st074407 74.3 µM -0.990409545813643 0.143723663159708 no 2927 0.160986990756347 941 809813
SGTC_1608 st001473 40.5 µM -0.991886290014843 0.143365128362534 no 2928 0.160626498870993 940 7292267
SGTC_2908 7930301 100 µM -0.99191794391772 0.143357449812845 no 2929 0.160618777530279 905 2223178
SGTC_776 4476-4378 112 µM -0.992537902371066 0.143207117331355 no 2930 0.160467599854501 957 2892008
SGTC_2386 9075165 157.42 µM -0.995881806873443 0.142398097100609 no 2931 0.159653787953216 923 16452277
SGTC_2441 5730946 39.09 µM -0.996384099139288 0.142276840727 no 2932 0.159531777931102 893 1774275
SGTC_118 0083-0097 135.343 µM -0.997852232511123 0.141922825122884 no 2933 0.159175508880415 950 5207356
SGTC_2468 5987765 72.9 µM -0.998844519372155 0.141683889938199 no 2934 0.158935007947959 920 26772094
SGTC_622 1348-1566 26.3 µM -0.999460942092076 0.141535597289635 no 2935 0.158785725320335 922 7340407
SGTC_1883 5-benzylidenerhodanine 20 µM -0.999915869681103 0.141426222950828 no 2936 0.158675611861998 911 1273210
SGTC_3323 9138564 53.9225 µM -1.00086853841636 0.14119736658977 no 2937 0.158445184327961 929 43912313 YNL103W MET4
SGTC_1596 piperlongumine 63 µM -1.00144769837687 0.141058359754826 no 2938 0.158305206871056 924 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3337 9144342 33.5465 µM -1.00274775344487 0.14074666566207 no 2939 0.157991291495965 914 17682949
SGTC_1154 4088-0362 150 µM -1.00747256605468 0.139617808280952 no 2940 0.156853867377507 924 6618304
SGTC_3122 9126309 49.47 µM -1.01279408573368 0.138353775888207 no 2941 0.155579263126199 956 17591206
SGTC_1706 st031321 9.9705 µM -1.01315510786667 0.138268304944617 no 2942 0.155493039694798 929 6103185
SGTC_880 0833-0487 87.2 µM -1.01387769816637 0.138097341927452 no 2943 0.155320557137844 930 76075
SGTC_752 1896-0090 130 µM -1.01567787261895 0.13767205236408 no 2944 0.154891404201128 929 772567
SGTC_128 0906-2981 13.371 µM -1.01652512267398 0.137472199983821 no 2945 0.154689695170517 924 6740226
SGTC_2469 5655019 90.81 µM -1.02098175222332 0.136424216103324 no 2946 0.153631542113983 935 2788239
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.02145581798822 0.136313061189586 no 2947 0.153519265721619 966 4620898
SGTC_692 k241-0027 77.8 µM -1.02278166813615 0.136002516168087 no 2948 0.153205543715996 914 3600480
SGTC_1326 1431-2094 10.8 µM -1.02795268442894 0.134795973801175 no 2949 0.151986042610552 946 616278
SGTC_499 genistein 192 µM -1.03116343792844 0.134050522008652 no 2950 0.151232091507743 960 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1749 st037932 54.2 µM -1.03245232333653 0.1337520752266 no 2951 0.150930135656384 964 594497
SGTC_1699 st031318 29.054 µM -1.03251203320361 0.133738260237636 no 2952 0.150916156756702 935 5340658
SGTC_403 arphamenine a 50 µM -1.03812524245714 0.132443918843761 no 2953 0.149605875471527 947 5487158 An arginine aminopeptidase inhibitor.
SGTC_52 0329-0193 875 nM -1.040880287767 0.131811805559961 no 2954 0.148965555721634 939 3739292
SGTC_2405 ticlatone 3.52 µM -1.04092918310234 0.131800605919941 no 2955 0.148954208168556 959 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2513 baicalein 25.65 µM -1.04288212150475 0.131353815569512 no 2956 0.148501445455215 958 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1842 st055362 61.2 µM -1.04525857485084 0.130811546093192 no 2957 0.147951738951312 925 676032
SGTC_348 k064-0012 10.7 µM -1.04689777971236 0.130438408118074 no 2958 0.147573363006801 930 5066323
SGTC_2450 5739737 12.93 µM -1.04857740821954 0.13005683265414 no 2959 0.147186329075624 926 2262825
SGTC_1640 st009078 66.4 µM -1.04881247679863 0.130003491821018 no 2960 0.147132216953839 940 690618
SGTC_2114 5491910 81.25 µM -1.04932845327013 0.129886461583801 no 2961 0.147013487404241 941 2849228
SGTC_732 3970-1727 52.7 µM -1.04940944913661 0.129868097283602 no 2962 0.146994855563383 951 1275699
SGTC_991 3996-0057 64.7 µM -1.05099157405909 0.129509740490292 no 2963 0.146631229867568 931 715343
SGTC_997 3996-0078 137 µM -1.05110065797454 0.129485057875081 no 2964 0.146606180966666 944 735687
SGTC_3010 9080089 71.4286 µM -1.05149042306624 0.129396891650456 no 2965 0.146516702809689 931 17027233
SGTC_3112 9123419 49.47 µM -1.05593984962944 0.128393363436717 no 2966 0.1454978482769 964 17015854
SGTC_2944 9067346 25.62 µM -1.05659952660849 0.128245040382923 no 2967 0.145347198327244 942 6473075
SGTC_2922 7999257 32.47 µM -1.05798488659167 0.127933940781033 no 2968 0.145031166359676 960 2988377
SGTC_2803 7707263 71.43 µM -1.0623035416185 0.126967500438909 no 2969 0.14404895356299 947 2199229
SGTC_1854 st056233 32.9 µM -1.06386012594056 0.126620412823491 no 2970 0.143696034357949 965 5393174
SGTC_3160 9100216 49.47 µM -1.06548495975427 0.126258812426349 no 2971 0.143328264082852 923 17191039
SGTC_3307 9126885 69.2785 µM -1.06557085945219 0.126239715835085 no 2972 0.143308838965915 942 24824909
SGTC_1441 4106-0040 13 µM -1.06621410790648 0.126096777531576 no 2973 0.143163433068539 937 2904180
SGTC_2458 5808907 16.39 µM -1.0714785039142 0.124931199012876 no 2974 0.141977165549728 942 2731747
SGTC_2729 fluphenazine 10.66 µM -1.07365463501079 0.124451592128437 no 2975 0.141488750368055 935 3372 An atypical antipsychotic.
SGTC_2420 aureobasidin a 50 nM -1.07462002126383 0.12423923927388 no 2976 0.14127244216506 950 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_553 k007-0256 45.7 µM -1.07747913248033 0.123611817263124 no 2977 0.140633134212815 950 6287000
SGTC_2145 5634607 200 µM -1.08075603015747 0.122895446396875 no 2978 0.139902826049279 964 308662
SGTC_2155 5570423 76 µM -1.08433973050683 0.122115342930816 no 2979 0.139107097773961 967 797402
SGTC_509 pifithrin 175 µM -1.08624981171282 0.12170097800751 no 2980 0.138684242423238 976 4817 A p53 inhibitor.
SGTC_1455 4262-0120 131 µM -1.08701921381946 0.121534346640198 no 2981 0.138514159191206 944 1529587
SGTC_1122 capsaicin 818.572 nM -1.0873202986146 0.121469183618639 no 2982 0.13844764040783 952 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1477 0139-0234 16 µM -1.08855618414332 0.121201961379357 no 2983 0.138174823831068 953 620880
SGTC_2495 cafestol 54.53 µM -1.08879302114996 0.121150799904721 no 2984 0.138122584930401 947 16667697 An anti-infammatory.
SGTC_2428 5615643 7.78 µM -1.09038044458193 0.120808277182439 no 2985 0.137772796194681 953 2253075
SGTC_1424 4048-1941 275 µM -1.09066190246142 0.120747617448805 no 2986 0.137710840095281 942 X1424
SGTC_1771 st048882 4.1505 µM -1.09233954310664 0.120386497490975 no 2987 0.137341942796283 962 4580403
SGTC_1985 st071382 65.5 µM -1.09297951485078 0.120248941239491 no 2988 0.137201397044312 978 6123237
SGTC_1848 st056003 16.4 µM -1.09304799767167 0.120234228025896 no 2989 0.137186363186346 918 146492
SGTC_447 ml7 120 µM -1.09425020697491 0.119976145537005 no 2990 0.136922628524707 979 4216 Selective myosin light chain kinase inhibitor.
SGTC_888 0916-0002 6.97 µM -1.09840774174602 0.119086644021247 no 2991 0.136013241678784 956 2802138 YIL048W NEO1
SGTC_2270 7924575 90.91 µM -1.10334941149704 0.118035446012917 no 2992 0.134937728264152 948 1262135
SGTC_3205 9113483 49.47 µM -1.10452653092827 0.117786018609675 no 2993 0.134682400637658 952 17018033
SGTC_677 0929-0063 136 µM -1.10476657600307 0.117735199735693 no 2994 0.134630373462531 987 1539583
SGTC_629 3448-6466 76.7 µM -1.10645267260485 0.117378680999155 no 2995 0.134265318981404 955 573744
SGTC_1363 1636-0063 10.4 µM -1.10715651192666 0.117230083251879 no 2996 0.134113132995742 946 6072185
SGTC_3015 9080845 49.47 µM -1.10877390832074 0.116889116269902 no 2997 0.133763864481072 961 5296973
SGTC_1341 1486-1360 280 µM -1.11167829941932 0.116278600665439 no 2998 0.133138246713057 975 3976547
SGTC_1304 1165-0502 251 µM -1.11362641476848 0.115870368245744 no 2999 0.132719744755632 950 767425
SGTC_2649 anisomycin 9.56 µM -1.11382215484865 0.115829406759497 no 3000 0.132677745233793 960 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2915 7971052 15.16 µM -1.11411649820312 0.115767830449368 no 3001 0.132614605858083 920 5741558
SGTC_704 1310-0270 142 µM -1.11508106189668 0.115566207704625 no 3002 0.132407843082581 942 5718033
SGTC_433 pimozide 108 µM -1.11569349287687 0.115438320817852 no 3003 0.132276678442057 966 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2184 6075246 200 µM -1.11638588745651 0.115293857215571 no 3004 0.132128495860649 938 2267320
SGTC_2100 5377183 190 µM -1.11710140028435 0.115144705202233 no 3005 0.131975485931399 929 2844202
SGTC_1973 st070275 50.2 µM -1.11910759863786 0.114727235464379 no 3006 0.131547119269019 959 17118334
SGTC_414 piperonyl butoxide 100 µM -1.11940159472007 0.114666148420132 no 3007 0.131484425473792 959 5794 A potent inhibitor of cytochrome P450.
SGTC_2837 9008476 45.46 µM -1.1197831389916 0.114586904968186 no 3008 0.131403093044255 955 2992805
SGTC_2058 5236698 133 µM -1.12089411929459 0.114356385942565 no 3009 0.131166467190319 936 766665
SGTC_1975 st070967 30.8 µM -1.12108451949235 0.114316912675928 no 3010 0.131125943728883 957 261391
SGTC_719 2810-4230 27.3 µM -1.1219627800536 0.114134959603123 no 3011 0.130939132778869 962 721079
SGTC_2152 5568786 200 µM -1.12234669041799 0.114055488044392 no 3012 0.13085753068329 960 5399883
SGTC_3301 9125354 19.7965 µM -1.12274332886527 0.113973423112323 no 3013 0.130773260089778 939 41905162
SGTC_2865 9030313 51.95 µM -1.1250762386003 0.113491592880765 no 3014 0.130278364650612 970 42562754
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.12607728152695 0.113285287297594 no 3015 0.130066404641905 958 97141
SGTC_2065 5221596 34.26 µM -1.12719336172851 0.113055589171178 no 3016 0.12983036826977 948 788581
SGTC_2683 piperine 63.03 µM -1.13035792757779 0.112406104319054 no 3017 0.129162717320493 960 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1279 0874-0590 65.2 µM -1.13311520041316 0.111842387833076 no 3018 0.128582939421344 963 3523074
SGTC_2380 9035439 200 µM -1.13380180721515 0.111702328014375 no 3019 0.128438846385933 950 6462575
SGTC_1358 1509-0022 2.48 µM -1.13390876892828 0.111680520366865 no 3020 0.128416409226021 954 3258434
SGTC_83 0170-0301 39.027 µM -1.13464682043011 0.111530127414239 no 3021 0.128261663696401 973 3089716
SGTC_496 calpeptin 138 µM -1.13498191497751 0.111461892965418 no 3022 0.128191447965937 951 73364 A calpain inhibitor.
SGTC_2939 9044578 71.43 µM -1.13668321673324 0.111115922108131 no 3023 0.127835368947317 969 2653634
SGTC_2272 7805186 180 µM -1.13885641203226 0.110675108046123 no 3024 0.127381524142041 970 2956062 YPR165W RHO1
SGTC_1195 1502-0147 41.1 µM -1.13982562509156 0.110478916110818 no 3025 0.127179477825012 940 817940
SGTC_3169 9102970 49.47 µM -1.14259776082251 0.109919146190199 no 3026 0.126602817833328 992 17027839
SGTC_1038 k292-0204 154 µM -1.14495557941563 0.109444642368375 no 3027 0.126113779367673 950 4454212
SGTC_810 3825-7150 143 µM -1.1451270391403 0.109410194090105 no 3028 0.126078268099314 930 22330411 YGL099W LSG1
SGTC_76 0433-0009 400.328 µM -1.1464837355337 0.109137892392317 no 3029 0.1257975265763 1004 2841569
SGTC_695 3505-6186 243 µM -1.1481564166009 0.108802840399843 no 3030 0.125451998855882 963 1819379
SGTC_2771 fluoxetine 41.05 µM -1.14866811549999 0.108700490723916 no 3031 0.125346429042932 955 3386 A selective serotonin reuptake inhibitor.
SGTC_34 0469-0683 81.75 µM -1.15224649367513 0.107986680662868 no 3032 0.124609898586758 969 3690923
SGTC_2244 6635614 200 µM -1.15632826138799 0.107176583295172 no 3033 0.12377345635457 980 836499
SGTC_2940 9060638 45.86 µM -1.15711162912107 0.107021612960632 no 3034 0.123613378035183 944 4027022
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.16067272567726 0.106319173544864 no 3035 0.122887508782088 976 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2062 5245942 200 µM -1.16212079047465 0.106034491740588 no 3036 0.122593201733893 988 1376160
SGTC_1303 1160-0052 261 µM -1.16239332541384 0.10598097446912 no 3037 0.122537866626717 935 3562476
SGTC_1297 1068-0111 14.1 µM -1.1631225107573 0.105837881433952 no 3038 0.122389900047866 961 767057
SGTC_1480 1070-0044 41.2 µM -1.1671104612394 0.105057768516418 no 3039 0.12158288186052 969 3124987
SGTC_789 1309-1135 70.6 µM -1.16793627527317 0.104896746312124 no 3040 0.1214162352148 957 3092424
SGTC_647 0140-0236 81 µM -1.17160796012359 0.104182982269657 no 3041 0.120677245359647 987 990837
SGTC_510 ag-490 170 µM -1.17187783209738 0.104130659238599 no 3042 0.120623054164938 986 5328779
SGTC_2028 5153890 36.43 µM -1.17254832827963 0.104000745279428 no 3043 0.120488490459949 979 2830968 YPR165W RHO1
SGTC_100 0086-0128 49.5915 µM -1.17271992778934 0.103967515408861 no 3044 0.120454068683583 971 93297
SGTC_1503 4585-0012 61.3 µM -1.17386673059205 0.103745637203795 no 3045 0.120224205093308 975 2922052
SGTC_3324 9138759 60.749 µM -1.17448449942784 0.103626256552316 no 3046 0.120100508514636 974 45595710
SGTC_3115 9123671 49.47 µM -1.17666466560452 0.103205747304191 no 3047 0.119664688161815 994 3286988
SGTC_2571 chrysanthemic acid 100 µM -1.18053872239035 0.102461581079829 no 3048 0.118893009489642 1002 2743 An insecticide.
SGTC_2154 5570129 200 µM -1.18237451073984 0.102110310722907 no 3049 0.11852856620544 997 673366
SGTC_2537 larixol 68.93 µM -1.18385147193498 0.10182833707185 no 3050 0.118235931428202 961 6708759
SGTC_3285 9112818 20.8695 µM -1.18396912212842 0.101805900313265 no 3051 0.118212643027081 965 17017947 YPR165W RHO1
SGTC_488 nitrendipine 139 µM -1.1862395052017 0.101373626115561 no 3052 0.117763864598893 1005 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1163 k060-0048 49.9 µM -1.18729362470608 0.101173380032866 no 3053 0.117555910963041 970 6809982
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.19633360537397 0.099467923298488 no 3054 0.115783199830995 937 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1849 st056239 19.2 µM -1.1971959756818 0.0993063355080935 no 3055 0.115615089033968 959 5393181
SGTC_453 enantio-paf c16 10 µM -1.19791215014492 0.0991722873027054 no 3056 0.115475609565622 972 13871343 A lipid and platelet activating factor
SGTC_2556 citropten 84.59 µM -1.19836673342872 0.0990872704667602 no 3057 0.115387138677591 970 2775 A potential DNA crosslinker.
SGTC_1019 4262-0212 3.4 µM -1.19937855100963 0.0988982302454991 no 3058 0.115190391949595 981 4677213
SGTC_845 0330-0138 4.51 µM -1.19945060001469 0.0988847792336957 no 3059 0.115176391207735 966 9039800
SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.20009848918275 0.0987638832916189 no 3060 0.115050546126015 992 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1144 3486-0183 12.5 µM -1.20150026019522 0.0985026834615921 no 3061 0.114778602806918 979 6744069
SGTC_1443 4112-3303 14 µM -1.20189039045339 0.098430078357645 no 3062 0.114702999023976 978 704433
SGTC_3325 9138760 55.175 µM -1.20456815695834 0.0979327905461715 no 3063 0.114185027850845 951 43844959
SGTC_2216 7189485 200 µM -1.20639301290303 0.097594953248459 no 3064 0.11383299442255 961 731273
SGTC_2123 5259487 200 µM -1.20763118606541 0.097366216241691 no 3065 0.113594578980218 979 2173474
SGTC_1850 st056238 17 µM -1.21004502361436 0.0969214211158174 no 3066 0.113130808441658 959 5393177
SGTC_1008 4106-0037 6 µM -1.21006684904246 0.0969174061853764 no 3067 0.113126621295061 968 2905394
SGTC_1135 dihydrocapsaicin 536.708 nM -1.21933691520495 0.0952231374639602 no 3068 0.111358171475018 988 107982 A Capsaicinoid.
SGTC_2974 9094440 9.66 µM -1.22000628998929 0.0951016469817427 no 3069 0.111231245227975 953 25236134
SGTC_49 0717-0965 32.132 µM -1.22012508687987 0.0950800974643764 no 3070 0.111208729894653 990 5889349 YGL099W LSG1
SGTC_2086 5274770 176.623 µM -1.22044154807467 0.0950227095907538 no 3071 0.111148767572061 961 689278
SGTC_1788 fluconazole 20 µM -1.22893814390961 0.0934914402206234 no 3072 0.109547499349754 970 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_539 4859-0462 2.54 µM -1.23658549595321 0.0921288752603058 no 3073 0.108120503641932 956 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1897 st060201 15 µM -1.23702608170612 0.0920508242792022 no 3074 0.108038699957084 994 611878
SGTC_3128 9127691 49.47 µM -1.238008468933 0.0918769679836562 no 3075 0.107856460314189 977 41316314
SGTC_330 1488-0319 80.1 µM -1.23865517128013 0.0917626517643664 no 3076 0.107736613453654 965 6846614
SGTC_1563 conessine 56.1 µM -1.2403889386255 0.0914566972977294 no 3077 0.10741578516691 991 441082 An anti-amoebic, histamine inhibitor.
SGTC_2156 5649887 115 µM -1.24442890660741 0.0907467069343821 no 3078 0.106670874786334 1003 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2947 9072639 7.68 µM -1.24512703706731 0.0906244319944991 no 3079 0.106542528577526 1007 16488146
SGTC_2364 9055074 200 µM -1.24685168792274 0.0903228901367068 no 3080 0.106225942017408 984 6470630
SGTC_1282 0886-0010 32.4 µM -1.24996247527871 0.0897808782284714 no 3081 0.105656627683623 969 2836211 YNL267W PIK1
SGTC_678 1218-2179 85.9 µM -1.25085911375692 0.0896251010902738 no 3082 0.105492941569661 1005 6820081 YOR116C RPO31
SGTC_2610 ononetin 44.17 µM -1.25110042347744 0.0895832115814872 no 3083 0.105448920537067 1004 259632
SGTC_1753 st043925 64 µM -1.2534843676562 0.0891701593424995 no 3084 0.105014742318219 1000 670181
SGTC_2304 7443016 91.4 µM -1.2535703458262 0.0891552889242763 no 3085 0.104999107670223 989 939854
SGTC_1675 st018485 24.5 µM -1.25701241189006 0.0885614785998781 no 3086 0.104374570593447 997 3323024
SGTC_40 0327-0103 19.753 µM -1.26150485094544 0.0877909009969222 no 3087 0.103563506678015 960 409036
SGTC_3120 9124077 49.47 µM -1.26264063272998 0.0875968773969062 no 3088 0.103359179160273 1019 18774327 YGL155W CDC43
SGTC_949 1165-0505 146 µM -1.26521179198401 0.0871588331133881 no 3089 0.102897708238429 993 6244267
SGTC_1473 k844-0725 134 µM -1.26871106961462 0.0865652976233265 no 3090 0.102272066454654 981 54682906
SGTC_761 k216-0224 480 µM -1.27352035949645 0.0857544991320293 no 3091 0.101416726328002 1021 1340404
SGTC_1790 st045711 43.5 µM -1.2749162528039 0.08552023319772 no 3092 0.101169442884157 936 585119
SGTC_844 0330-0132 15.3 µM -1.27494891817274 0.0855147568734775 no 3093 0.101163661458082 982 2828079
SGTC_2427 5545055 42.75 µM -1.27769806519936 0.0850548050168689 no 3094 0.100677953852829 981 5372858
SGTC_1616 st002734 56.1 µM -1.27777668509801 0.0850416786727292 no 3095 0.100664088683412 984 4026101
SGTC_376 3970-0862 59.1 µM -1.27886046964357 0.0848608851727868 no 3096 0.100473097606592 982 3135186
SGTC_1632 st005650 90 µM -1.28177674514157 0.0843758324410457 no 3097 0.099960487058263 985 2759605
SGTC_2126 5251174 33.877 µM -1.2818326942931 0.0843665470185928 no 3098 0.0999506712608668 990 790722
SGTC_2195 6536160 144.242 µM -1.28367589009971 0.0840610754653813 no 3099 0.0996276918859194 989 3834386
SGTC_200 k038-0079 37.545 µM -1.28417988114073 0.0839776941288976 no 3100 0.0995395114998536 1017 3436683
SGTC_188 3229-0966 278.469 µM -1.28639105234732 0.0836126071469229 no 3101 0.0991533097712285 976 5722370
SGTC_545 4218-0007 221 µM -1.28785366666062 0.0833717707002996 no 3102 0.0988984533633622 993 2840508
SGTC_130 0136-0219 337.655 µM -1.28793090994439 0.0833590662072065 no 3103 0.0988850072759588 999 234244
SGTC_861 0443-0273 110 µM -1.28815287469645 0.0833225669297303 no 3104 0.0988463763129761 984 6149169
SGTC_2841 9004761 38.96 µM -1.2888908749998 0.0832012985518054 no 3105 0.0987180134132652 983 2991039
SGTC_1905 st060207 84.5 µM -1.29274776398679 0.0825696919057667 no 3106 0.0980491560707414 983 1948547
SGTC_3225 9130819 49.47 µM -1.29331104137355 0.082477752075935 no 3107 0.0979517516927263 989 4547121
SGTC_620 0109-0052 432 µM -1.29342950118864 0.0824584265208257 no 3108 0.0979312761337919 1004 493037
SGTC_158 k038-0087 26.446 µM -1.29665894989214 0.0819328861298417 no 3109 0.0973742797711649 956 X158
SGTC_3028 9087778 49.47 µM -1.29869481768185 0.0816028812115065 no 3110 0.0970243416378758 973 17217395
SGTC_971 1315-0384 26.7 µM -1.29933355010736 0.0814995523992589 no 3111 0.0969147426455054 1013 6769120
SGTC_1281 0884-0031 11.8 µM -1.300072895918 0.0813800704338126 no 3112 0.0967879931066725 998 1548255
SGTC_2687 chenodiol 100 µM -1.30111191596801 0.0812123829906179 no 3113 0.0966100748018931 970 5702181 A cholesterol synthesis inhibitor.
SGTC_2099 5377090 177.372 µM -1.30580318896845 0.0804585030915614 no 3114 0.0958097476647482 985 2243829
SGTC_1648 st011736 69.8 µM -1.30638149824124 0.0803659369893995 no 3115 0.0957114272512169 998 2855514
SGTC_2618 avocadyne 43.43 µM -1.30742824092373 0.0801985965535649 no 3116 0.0955336556220727 1002 3015189
SGTC_1722 st034304 3.6505 µM -1.3126925520294 0.0793609935573633 no 3117 0.0946432841637696 1014 4036148 YLR033W RSC58
SGTC_2232 chlorophetanol 41.5365 µM -1.31349275625018 0.0792342551901234 no 3118 0.0945084801062916 1009 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.31513779285696 0.07897419153336 no 3119 0.0942317985732217 1012 61125 An anti-inflammatory.
SGTC_1763 st044482 94.5 µM -1.32015246962827 0.0781854110839159 no 3120 0.0933920587260169 986 88505
SGTC_696 1560-0013 611 µM -1.32497633717407 0.0774322965418014 no 3121 0.0925894998859331 993 1650269
SGTC_1513 0337-0559 19 µM -1.32498783083713 0.0774305087244635 no 3122 0.0925875937682423 1003 775073
SGTC_32 0928-0142 34.1 µM -1.3282689357054 0.0769214199538907 no 3123 0.0920446390803334 991 2244242
SGTC_1674 st016616 23.6 µM -1.32855450551368 0.0768772322357057 no 3124 0.0919974949679563 983 625830
SGTC_2937 9044753 11.33 µM -1.33230852757459 0.0762981454927603 no 3125 0.0913794130496137 956 6465530 YGL099W LSG1
SGTC_1366 1683-0113 21.9 µM -1.3345406971828 0.0759553933331136 no 3126 0.0910133592413072 1012 708623
SGTC_923 1900-2434 73.3 µM -1.33600407984214 0.0757313263439995 no 3127 0.0907739698961451 987 5910570
SGTC_71 0417-1750 47.813 µM -1.33748473322108 0.0755051277417165 no 3128 0.0905322311755175 953 6811472
SGTC_8 0354-0001 70 µM -1.338402756027 0.0753651406878972 no 3129 0.0903825904891865 1000 4993152
SGTC_906 1165-0455 526 µM -1.34432864481626 0.074466272080933 no 3130 0.0894210683153297 1000 3252859
SGTC_2147 5545932 89.7195 µM -1.34471463449743 0.0744080083620205 no 3131 0.0893587033984086 1023 797404
SGTC_2063 5246145 200 µM -1.34678150094133 0.0740966145036031 no 3132 0.0890253071811259 1000 711240
SGTC_693 4161-2696 114 µM -1.35778197988864 0.0724560085011672 no 3133 0.0872664372737107 1013 805759
SGTC_1305 1181-0477 144 µM -1.36284180882509 0.0717107962398255 no 3134 0.0864661857333276 1018 6252086
SGTC_349 k015-0014 24 µM -1.367741806158 0.0709947415039344 no 3135 0.0856964544962469 1009 2196908
SGTC_1922 5578187 25 µM -1.36953316817751 0.0707343383462927 no 3136 0.0854163370931248 955 1350412
SGTC_1613 st002381 52.1 µM -1.37142779234664 0.0704597236541609 no 3137 0.0851208193158642 993 551167
SGTC_590 k048-0076 22.4 µM -1.37182981473134 0.0704015584113482 no 3138 0.085058211729682 1020 6832814
SGTC_201 4262-0159 12.803 µM -1.37575031841794 0.0698362675328723 no 3139 0.0844494737808941 1032 1341029
SGTC_796 1234-0020 70.7 µM -1.37905600007178 0.0693623468517348 no 3140 0.0839387442664796 973 46495034
SGTC_2996 9066192 71.4286 µM -1.38520004698173 0.0684880883693395 no 3141 0.0829956531785648 995 6472854
SGTC_2760 etidronate 98.04 µM -1.38744577899652 0.068170665081307 no 3142 0.0826529369226775 996 3305 A chelator and antioxidant.
SGTC_954 1189-0853 2.85 µM -1.3876267156983 0.0681451400724227 no 3143 0.0826253710005194 986 2828194
SGTC_1921 5740136 50 µM -1.39288127540754 0.0674070850641699 no 3144 0.0818278477818636 988 1774243
SGTC_1182 1222-0449 220 µM -1.39337857853313 0.0673375551852751 no 3145 0.0817526700002076 1006 658318
SGTC_2197 6588183 93.1375 µM -1.39870748075937 0.0665959764478407 no 3146 0.0809503600105806 998 884136
SGTC_1018 4259-0013 28.1 µM -1.39879858819747 0.0665833529722214 no 3147 0.0809366949002948 1010 6801262
SGTC_1878 temozolomide 1 mM -1.40095259927481 0.0662854411901368 no 3148 0.0806141240465186 988 5394 DNA alkylating agent.
SGTC_2994 9053520 71.4286 µM -1.40165495346069 0.0661885251713595 no 3149 0.0805091541966464 1006 4647384
SGTC_1893 st059353 36.1 µM -1.40259911336321 0.0660584160001218 no 3150 0.080368208183182 1024 3112488
SGTC_3228 9131799 49.47 µM -1.40515486787111 0.0657072164696351 no 3151 0.0799876157040552 1023 17015818
SGTC_1242 0402-0103 60.1 µM -1.40696370025771 0.0654595313835268 no 3152 0.0797190764581095 989 432868
SGTC_1103 duloxetine 36.1 µM -1.40828023415771 0.0652797129498428 no 3153 0.0795240530749349 1028 60835 A selective serotonin reuptake inhibitor.
SGTC_2805 7950783 58.44 µM -1.40895343920468 0.0651879116184388 no 3154 0.0794244681548497 1002 1178958 YDL195W SEC31
SGTC_1484 3473-2379 286 µM -1.40994626494683 0.0650527081813377 no 3155 0.0792777751168032 1051 671917
SGTC_1665 st014639 11.4 µM -1.41383404799795 0.0645253621077147 no 3156 0.0787053170139928 1003 981133 YIL048W NEO1
SGTC_792 4534-1957 155 µM -1.41691142000156 0.0641103012478038 no 3157 0.0782544136072747 1010 1717904
SGTC_599 1935-0052 86.5 µM -1.42065539636298 0.0636081342109063 no 3158 0.0777084827118379 1014 9557311
SGTC_955 1216-0110 33 µM -1.42982924676058 0.0623906144813383 no 3159 0.0763830163953814 1010 3619719
SGTC_2171 5739187 198.077 µM -1.42996216504278 0.0623731085610679 no 3160 0.0763639391721489 993 2262761
SGTC_998 3996-0085 177 µM -1.43221438653628 0.0620770630904823 no 3161 0.076041237848676 1016 715391
SGTC_1808 st050063 61.5 µM -1.43384862380387 0.0618629363789343 no 3162 0.0758077328678328 1012 4011993
SGTC_1076 itraconazole 331 nM -1.434545169646 0.061771846535584 no 3163 0.0757083743473339 1016 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1396 3511-0007 98.6 µM -1.43496963192352 0.0617163894174926 no 3164 0.0756478757479746 1002 X1396
SGTC_2906 7926292 26.41 µM -1.44382139630451 0.0605687184519062 no 3165 0.0743946108716088 1018 2966319
SGTC_2258 7960471 200 µM -1.44480956105835 0.0604416412958365 no 3166 0.0742556923829292 1036 2974708
SGTC_315 k915-0449 187 µM -1.44509885007902 0.0604044784761736 no 3167 0.0742150609733535 1012 20970215 YNL149C PGA2
SGTC_224 benfluorex 43.875 µM -1.44746853552672 0.060100735293026 no 3168 0.0738828713485106 1033 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_168 3970-0862 530.542 µM -1.45098314189231 0.0596524413853749 no 3169 0.0733922772619664 995 3135186
SGTC_1212 0520-0165 585 µM -1.45197437237287 0.0595264831434585 no 3170 0.0732543656065634 1029 5403258
SGTC_1016 4226-1401 38 µM -1.45486196226883 0.0591607375180633 no 3171 0.0728537400744538 1005 2901613
SGTC_2143 5623677 140.463 µM -1.45585761801718 0.0590350359807826 no 3172 0.0727159919245325 983 5375313
SGTC_2779 methotrexate 400 µM -1.46551219977359 0.0578269847587775 no 3173 0.0713906131794025 990 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2885 9057732 51.95 µM -1.46638082024065 0.0577192566016774 no 3174 0.0712722842598084 1014 6471414
SGTC_2734 clemastine 41.6 µM -1.47221943374274 0.0569992294401989 no 3175 0.0704808155744901 1055 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_3286 9117135 37.221 µM -1.47881976398402 0.0561938025987777 no 3176 0.0695942460719073 1015 3438150
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.49111184602502 0.0547177640010907 no 3177 0.0679660663573055 1016 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2390 9097792 176.6 µM -1.49188123303018 0.0546264047623659 no 3178 0.0678651416633948 1012 4497149
SGTC_2453 5731132 22.18 µM -1.49916229724652 0.0537677902092647 no 3179 0.0669157666975626 1031 1362040
SGTC_2964 9083345 53.42 µM -1.49935554383889 0.0537451481769419 no 3180 0.0668907100323778 994 17741579
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.50079863192735 0.0535763052150041 no 3181 0.0667038263240593 1027 551469
SGTC_1826 st055655 41.6 µM -1.50541882776185 0.0530385620084156 no 3182 0.0661082157635014 1039 676168
SGTC_2710 st078562 53.7235 µM -1.50655403027331 0.0529070933162007 no 3183 0.065962504019946 1024 17250908
SGTC_1502 4534-4282 27.7 µM -1.51132382101231 0.0523575225757341 no 3184 0.065352983844955 1045 3278949
SGTC_3091 9116372 49.47 µM -1.51177228192116 0.0523060853128944 no 3185 0.0652959015361962 1028 17169793
SGTC_1516 st013856 110 µM -1.51231713144472 0.0522436465332338 no 3186 0.0652266024625936 1026 5281404 A mutagen and neurotoxin.
SGTC_2614 arthonioic acid 13.39 µM -1.51246604307388 0.0522265918306245 no 3187 0.065207672417478 1026 6710684
SGTC_2482 5981709 142.65 µM -1.52228012253492 0.0511123097505164 no 3188 0.0639694532504627 1015 877755
SGTC_526 4469-0568 170 µM -1.53571243199125 0.0496179779921947 no 3189 0.0623044623229485 1010 2901964
SGTC_114 0364-0001 490.298 µM -1.53714587437246 0.0494605891302281 no 3190 0.0621287956313249 1035 4003655
SGTC_53 0973-0023 39.979 µM -1.5452552166968 0.0485776911552667 no 3191 0.0611422715620608 1017 674768
SGTC_3008 9078912 71.4286 µM -1.54773749037307 0.0483099689365522 no 3192 0.0608427559442633 1037 16648731
SGTC_2093 5331342 194.4 µM -1.55280542422168 0.047767039045909 no 3193 0.0602348132275843 1029 33839
SGTC_2437 5741531 144.16 µM -1.55364223913269 0.0476778625022819 no 3194 0.0601348889890091 1001 2262990
SGTC_1115 galangin 695.678 nM -1.55857694848389 0.0471546953231524 no 3195 0.0595482712304231 1041 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1199 1638-0010 4.46 µM -1.55997346903508 0.0470074776695362 no 3196 0.0593830754867164 1022 3111136
SGTC_3201 9113999 49.47 µM -1.56754212186855 0.0462160095162766 no 3197 0.0584940142956095 1017 16649224
SGTC_1378 2093-0007 380 nM -1.57856429793621 0.0450825779541484 no 3198 0.0572180145576141 1033 3618014
SGTC_3052 9092717 49.47 µM -1.57910402124755 0.0450276568443739 no 3199 0.0571560997446992 1024 25237534
SGTC_1042 0350-0096 82 µM -1.57927713940243 0.0450100521155083 no 3200 0.0571362515240808 1029 3122515
SGTC_2601 securinine 100 µM -1.58224543014194 0.0447090616836991 no 3201 0.056796776473747 1012 442872 A GABA receptor antagonist.
SGTC_2790 5423970 71.43 µM -1.58453244942742 0.0444782608334875 no 3202 0.0565363016646023 1021 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2872 9044037 25.97 µM -1.58573943160959 0.0443568424459432 no 3203 0.0563992151743207 1046 6465195
SGTC_2549 cedrol 20.94 µM -1.58603908959621 0.0443267392768513 no 3204 0.0563652212817322 1017 6708665 A sedative which affects the nervous system.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.59127216338131 0.0438036824665103 no 3205 0.0557741693041951 1032 4213774
SGTC_701 4424-0219 185 µM -1.5956487890259 0.0433700629961044 no 3206 0.055283614081944 1038 2911779
SGTC_981 1488-1094 54.9 µM -1.59675951246398 0.0432605698847271 no 3207 0.0551596620652013 1025 3449522
SGTC_151 3013-0144 2.285 µM -1.59875018324008 0.0430648917819481 no 3208 0.0549380610844556 1018 906558 YHR107C CDC12
SGTC_2497 7-hydroxyflavone 100 µM -1.6020036817972 0.0427466206189205 no 3209 0.0545773976648524 1031 5281894
SGTC_1940 st075990 51.1 µM -1.61788141378871 0.0412205725922759 no 3210 0.0528440782470614 1044 1084979
SGTC_2470 5664817 21.68 µM -1.62089320040009 0.0409361467149877 no 3211 0.0525202726926097 1055 2859561
SGTC_1841 st054148 70 µM -1.62386747386632 0.0406568278835053 no 3212 0.0522020478566245 1042 675442
SGTC_3188 9110789 49.47 µM -1.62472861163403 0.0405762464230378 no 3213 0.0521101990377619 1032 849217
SGTC_1696 st025591 34.7925 µM -1.62592441964674 0.0404645630599764 no 3214 0.0519828672960109 1022 2787147
SGTC_1442 4112-3290 3 µM -1.63064323027304 0.0400262795970483 no 3215 0.0514828108658205 1054 704353
SGTC_1064 honokiol 6.76 µM -1.63427286530813 0.0396917900919281 no 3216 0.0511007843105055 1046 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1843 st055809 45.5 µM -1.64075565197502 0.0391000250498569 no 3217 0.0504240737319696 1046 16413835
SGTC_1255 0566-0045 221 µM -1.64473714920715 0.0387401577549746 no 3218 0.0500120141575755 1024 2788469
SGTC_656 4090-1979 187 µM -1.65503579717278 0.0378218186065479 no 3219 0.0489586183889514 1043 22330961
SGTC_2904 7225135 42.03 µM -1.65600896762223 0.0377359666608403 no 3220 0.0488600013946943 1060 4446116
SGTC_952 1185-0122 232 µM -1.66272075461739 0.0371481833761743 no 3221 0.0481841728581874 1031 678600
SGTC_78 0336-0123 156.75 µM -1.66336935381707 0.0370917810694662 no 3222 0.0481192618626889 1036 6765896
SGTC_2680 butyl paraben 22.24 µM -1.66702086036463 0.0367755501942565 no 3223 0.047755128495622 1067 7184 An antifungal and steroid mimetic.
SGTC_44 0929-0055 61.211 µM -1.66795434556203 0.0366950625652676 no 3224 0.0476623950516248 1006 1379590
SGTC_1125 tnp00248 1.32998 µM -1.67035842077692 0.0364884398643337 no 3225 0.0474242354691128 1036 24207736
SGTC_3151 9099821 49.47 µM -1.67036539728088 0.0364878416440155 no 3226 0.0474235457322142 1028 17174189
SGTC_802 4112-3352 742 µM -1.6704284659672 0.0364824340030304 no 3227 0.0474173107675982 1033 704594
SGTC_2592 piperlongumine 83.33 µM -1.67274878067734 0.0362839408093004 no 3228 0.0471883808974272 1043 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1511 0906-3109 28.5 µM -1.68314702164503 0.0354052448908091 no 3229 0.0461733168408129 1037 2882180
SGTC_3276 9139060 49.47 µM -1.6849423987605 0.0352553090266431 no 3230 0.0459998426570707 1045 4870619
SGTC_1914 st062367 72.6 µM -1.68752555077722 0.0350404985305819 no 3231 0.0457511705686461 1032 978205
SGTC_1667 st014849 34.6 µM -1.68763281792787 0.0350316016568915 no 3232 0.0457408677019779 1033 5348460
SGTC_429 1112-0049 25.5 µM -1.6887689921462 0.0349374796860342 no 3233 0.0456318541322767 1039 2836170
SGTC_2368 9071271 200 µM -1.69774465103827 0.0342012006143023 no 3234 0.0447779832188488 1045 27209959
SGTC_3124 9127567 49.47 µM -1.70040605785624 0.0339853518075148 no 3235 0.0445272865708466 1027 17592030
SGTC_2394 5221648 200 µM -1.70353651773293 0.0337328964677386 no 3236 0.0442338550458117 1052 788586
SGTC_3200 9114385 49.47 µM -1.71278240315596 0.0329962595647222 no 3237 0.0433762893072767 1028 17018030 YLR208W SEC13
SGTC_2593 nobiletin 86.24 µM -1.71546744818125 0.0327848380143552 no 3238 0.0431297792742406 1028 72344 An anti-infammatory.
SGTC_1151 3909-8316 15.3 µM -1.71567320820894 0.0327686825620733 no 3239 0.0431109355246848 1044 800431
SGTC_2583 asiatic acid 100 µM -1.71919170379783 0.0324934386591715 no 3240 0.0427897354740602 1045 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1046 2001-0062 216 µM -1.71991210068563 0.0324373195239446 no 3241 0.042724210298398 1043 739778
SGTC_1950 st077106 7.18 µM -1.72406760089467 0.03211516375828 no 3242 0.0423478200706397 1024 13831864
SGTC_2842 9000675 19.48 µM -1.72461792961411 0.0320726981959606 no 3243 0.042298175041023 1028 2989072
SGTC_2755 lomerizine 42.69 µM -1.72633873165504 0.0319402132706049 no 3244 0.0421432456083769 1036 3949 A calcium channel blocker.
SGTC_1298 1079-1278 263 µM -1.72675854164773 0.031907960681119 no 3245 0.0421055185111904 1045 2840950
SGTC_375 3970-0961 9.27 µM -1.72785677348917 0.0318237144318482 no 3246 0.0420069528986908 1025 2898222
SGTC_2934 9036370 36.88 µM -1.73073103161976 0.0316040971969581 no 3247 0.041749873924657 1024 6462800
SGTC_1748 st037455 53.6035 µM -1.73220874321161 0.0314916761671436 no 3248 0.0416182014467227 1051 580690
SGTC_2478 5763493 32.33 µM -1.7355793798224 0.0312364822458286 no 3249 0.0413191172826166 1033 1365576 YLR208W SEC13
SGTC_1080 nisoldipine 24.4 µM -1.73602756196812 0.0312026791665177 no 3250 0.0412794806259331 1048 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2314 7727897 200 µM -1.74165230512167 0.0307810131141246 no 3251 0.040784651480857 1019 900724
SGTC_2200 6600604 21.907 µM -1.74245892473367 0.0307209324069572 no 3252 0.0407140864409958 1060 2904777
SGTC_2404 5161160 200 µM -1.74814206148364 0.0303003730550512 no 3253 0.0402197156035424 1030 2831543
SGTC_1550 gossypolone 36.6 µM -1.7718079760437 0.0286000457248688 no 3254 0.0382132190590907 1049 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1077 5-fluorocytosine 377 nM -1.78204290682022 0.0278896772656963 no 3255 0.0373711175147492 1049 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1540 guanosine 70.6 µM -1.79015817764914 0.0273369283636243 no 3256 0.0367142431618775 1047 6802 Guanosine is a purine nucleoside
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.79169488088693 0.0272332958102408 no 3257 0.0365909275013831 1042 165506
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.79736411237716 0.0268538035745659 no 3258 0.0361389170821551 1068 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2653 dihydrofissinolide 100 µM -1.8056521660818 0.0263069635520223 no 3259 0.0354863443825731 1064 6857746
SGTC_651 3253-0966 34.4 µM -1.80901663020643 0.0260876504688436 no 3260 0.0352242098901081 1061 781462
SGTC_2287 7945887 168.79 µM -1.81788233340895 0.0255170513194227 no 3261 0.0345410595249744 1047 1245853
SGTC_567 1080-0542 68.4 µM -1.8252615339961 0.0250501280043865 no 3262 0.0339807859665466 1044 5950415
SGTC_714 4296-0578 26.1 µM -1.82819641944224 0.02486642267829 no 3263 0.0337600391033676 1061 1589775
SGTC_3089 9117425 49.47 µM -1.83401652811016 0.0245054613178922 no 3264 0.0333257703713778 1059 9401657
SGTC_3050 9093513 49.47 µM -1.83520012106985 0.0244325959237738 no 3265 0.0332380216119343 1029 25236664
SGTC_3163 9099914 49.47 µM -1.85011949468055 0.0235296075862753 no 3266 0.0321481643782634 1075 16268368
SGTC_1093 fluphenazine 7.97 µM -1.85465682249466 0.0232606188254571 no 3267 0.0318226241191461 1080 6602611 An atypical antipsychotic.
SGTC_872 0588-0139 234 µM -1.86050063073822 0.0229179952040221 no 3268 0.0314073646503788 1059 2047100
SGTC_2280 7785178 200 µM -1.86964509660447 0.0223903896442822 no 3269 0.0307665592258968 1044 2954328
SGTC_1583 clindamycin 39.6 µM -1.88215535646999 0.0216852137774956 no 3270 0.0299074625681896 1066 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1612 st002233 45.4 µM -1.89185052566712 0.0211517072904914 no 3271 0.0292554495907551 1047 1035021
SGTC_142 0335-0849 62.6745 µM -1.90154395013914 0.0206294397104453 no 3272 0.0286154007577288 1044 3889043 YPR107C YTH1
SGTC_595 3909-8003 73.7 µM -1.9103011098083 0.0201670486181071 no 3273 0.0280472274871066 1072 699517
SGTC_1982 st072467 71.9 µM -1.91450793161763 0.0199480658769204 no 3274 0.0277776433259845 1060 3163533
SGTC_2243 6634756 200 µM -1.92363634980841 0.0194798241075027 no 3275 0.0272000907115604 1045 885676
SGTC_1136 pergolide 1.05886 µM -1.9238926801594 0.0194668115748693 no 3276 0.0271840184714708 1056 47811 A dopamine receptor agonist.
SGTC_153 4077-0274 519.67 µM -1.92755117721541 0.0192818923798588 no 3277 0.0269554883085714 1047 3121976
SGTC_1367 1812-0510 76.9 µM -1.92761541371661 0.0192786589200304 no 3278 0.0269514901080493 1053 1142582 YDR527W RBA50
SGTC_2081 5214970 32.255 µM -1.93146478460129 0.0190857333486535 no 3279 0.026712800103418 1064 2063512
SGTC_1045 1348-1485 165 µM -1.94966562489862 0.0181956137797012 no 3280 0.0256079930050737 1061 6810614
SGTC_2050 5263056 171 µM -1.95758955103488 0.0178192877333597 no 3281 0.0251390972159604 1060 763468 YGL055W OLE1
SGTC_2959 9079155 11 µM -1.96049277156078 0.0176830787730702 no 3282 0.0249691110165919 1062 16189457
SGTC_2005 4024620 188 µM -1.96692351164376 0.0173845315707961 no 3283 0.024596014753417 1066 236743
SGTC_36 0335-0881 14.2 µM -1.96773933022101 0.0173469666390993 no 3284 0.0245490190075122 1030 23828853
SGTC_1856 st057054 55.7 µM -1.98126243624753 0.0167343131819723 no 3285 0.02378092529786 1055 1266018
SGTC_1539 benzyladenosine 56 µM -1.99748886723172 0.0160237050458812 no 3286 0.0228860513166018 1064 92208 A nucleotide analog.
SGTC_2328 6201408 200 µM -1.99944356403545 0.0159398737308998 no 3287 0.0227801911850952 1052 2890418
SGTC_756 0508-1999 28.3 µM -2.00808907450496 0.0155735872349266 no 3288 0.0223169135260017 1062 6753853
SGTC_1726 st035556 14.5795 µM -2.01583630612984 0.0152515182768085 no 3289 0.0219085478635792 1049 5919439
SGTC_1717 st033143 58.0435 µM -2.01705126669356 0.0152015323113995 no 3290 0.0218450817714604 1059 674616
SGTC_170 4197-0004 226 µM -2.0178718118662 0.0151678530797439 no 3291 0.0218023067215872 1064 218692
SGTC_1738 st035555 74 µM -2.03374688540647 0.0145287680832618 no 3292 0.0209885611454541 1058 5331140
SGTC_3257 9139206 32.98 µM -2.03376180379178 0.014528178583553 no 3293 0.0209878086968122 1068 4910041
SGTC_1451 4152-0210 104 µM -2.04492242519224 0.0140928959433857 no 3294 0.0204312533356241 1059 659563
SGTC_2132 5317594 122.667 µM -2.05210588378829 0.0138187136256163 no 3295 0.0200796866314054 1066 794577
SGTC_877 0771-0151 33.1 µM -2.05429999649348 0.0137358900236465 no 3296 0.0199733325450711 1076 6166523
SGTC_1060 3448-7350 82 µM -2.06835846422382 0.0132153049295785 no 3297 0.0193031639579759 1061 570178
SGTC_355 1311-2252 105 µM -2.06908640411123 0.013188819839464 no 3298 0.0192689896628509 1073 5338538
SGTC_1146 3579-1023 7 µM -2.08326481732732 0.012682029018021 no 3299 0.0186135459023554 1078 X1146
SGTC_277 nystatin 15.5 µM -2.08384651211392 0.0126616019158937 no 3300 0.0185870654901285 1077 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1167 k781-0610 148 µM -2.08540930234652 0.01260686310108 no 3301 0.0185160815848814 1058 4525169
SGTC_1333 1482-0047 286 µM -2.08599910399308 0.0125862578151711 no 3302 0.0184893521124796 1064 3811116
SGTC_1028 k015-0029 4.8 µM -2.08829370850271 0.0125063706979223 no 3303 0.0183856743218132 1068 4588309
SGTC_99 0109-0120 622.8 µM -2.09209036973638 0.0123751532401515 no 3304 0.018215216234078 1064 759414
SGTC_753 1322-0200 289 µM -2.1027198291921 0.012014109547329 no 3305 0.0177451338275863 1079 5403907
SGTC_2480 5767542 37.17 µM -2.12010132900623 0.0114433946369517 no 3306 0.0169987504568122 1071 2867358
SGTC_1546 5-methoxyflavanone 78.7 µM -2.12318844479488 0.0113445320910809 no 3307 0.016869031936267 1081 147795
SGTC_3043 9092303 49.47 µM -2.12700282179375 0.0112234052942208 no 3308 0.0167099243684992 1059 25236084
SGTC_296 1222-0039 74.9 µM -2.13374655261878 0.0110120054011518 no 3309 0.0164317665615318 1073 5984176
SGTC_762 1165-0429 115 µM -2.15427154912615 0.0103897691072778 no 3310 0.0156094413442785 1065 5967793
SGTC_2085 5307070 144.047 µM -2.17403647165572 0.00981977010336539 no 3311 0.0148511981366778 1078 2840351
SGTC_718 1130-0073 349 µM -2.17719478804555 0.00973126508784922 no 3312 0.0147330185119377 1076 6740020
SGTC_3057 9095946 49.47 µM -2.18645874287075 0.00947567065441857 no 3313 0.0143910299747651 1083 24540043
SGTC_811 0416-0114 265 µM -2.20484796710992 0.00898564923421761 no 3314 0.013732382397474 1073 6612453
SGTC_1714 st033236 13.627 µM -2.21505039717959 0.00872347372274882 no 3315 0.0133783027677883 1061 2916566
SGTC_3293 9120939 62.045 µM -2.21529189058045 0.00871735010051879 no 3316 0.0133700180546585 1075 934087
SGTC_771 0250-0039 27.3 µM -2.22778328626035 0.00840569822932989 no 3317 0.0129474849645794 1072 3005115
SGTC_300 r073-0011 5.04 µM -2.23557811425036 0.00821621670361911 no 3318 0.0126897097653542 1087 2735780
SGTC_2754 granisetron 64.02 µM -2.24934268666856 0.00789076848245007 no 3319 0.0122453509850782 1069 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_3209 9113616 49.47 µM -2.24957324596975 0.00788541511501259 no 3320 0.0122380241839976 1071 16649353
SGTC_1384 3089-0840 101 µM -2.26908567783057 0.0074437729359684 no 3321 0.0116315580773469 1072 1069836
SGTC_1155 4088-0394 48.2 µM -2.27135874524989 0.00739376924104602 no 3322 0.0115626348387974 1075 2326248
SGTC_2516 gossypol 71.55 µM -2.28282184861717 0.00714608435273229 no 3323 0.0112204322166675 1077 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1131 3454-3128 32.3 µM -2.31270128568668 0.00653455750088307 no 3324 0.0103695341462765 1059 710982
SGTC_1329 1447-1697 50.6 µM -2.32683875831847 0.00626169514436005 no 3325 0.00998692435035766 1081 2840515
SGTC_783 0848-0141 92.7 µM -2.33993954379133 0.00601789819604541 no 3326 0.00964343082803562 1082 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3253 9135987 49.47 µM -2.34466299750563 0.00593208385114252 no 3327 0.0095221421411129 1076 4182430
SGTC_2228 7354201 200 µM -2.41938408853582 0.00471173691580437 no 3328 0.00777340734114802 1092 753451
SGTC_3013 9080133 71.4286 µM -2.47811298384842 0.00391536440483887 no 3329 0.00660396567346528 1084 17050193
SGTC_905 2-aminofluorene 215 µM -2.4915008712206 0.00375163875812367 no 3330 0.00636023275619431 1079 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1689 st020265 53.493 µM -2.50001275395217 0.00365076286270466 no 3331 0.006209441774234 1082 5758320 YPR016C TIF6
SGTC_37 0566-0070 1.56 µM -2.50749353197623 0.00356412344225577 no 3332 0.00607954034434458 1083 1626686
SGTC_520 3584-0023 682 µM -2.51107119537075 0.00352334453721539 no 3333 0.00601827094738116 1075 1340790
SGTC_1448 4255-0083 152 µM -2.5260406341937 0.00335722642814381 no 3334 0.00576780689780552 1086 5399660
SGTC_782 0083-0095 30.5 µM -2.54055660037954 0.0032028989860749 no 3335 0.0055338089073467 1084 3591729 An indicator and reagent.
SGTC_2793 7325131 81.82 µM -2.55700607551687 0.00303575387082973 no 3336 0.00527886867693008 1082 4176441
SGTC_715 0868-0130 184 µM -2.57647812420109 0.00284807843572999 no 3337 0.00499062605604643 1091 2876258
SGTC_2512 diallyl trisulfide 49.23 µM -2.58479296643611 0.00277117685515787 no 3338 0.00487187429418874 1088 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3156 9099931 49.47 µM -2.64977549700683 0.00223183165418404 no 3339 0.0040272636727637 1091 18111053
SGTC_1904 st060225 78 µM -2.65059385941446 0.00222569259522039 no 3340 0.00401751990867084 1070 66595
SGTC_3159 9100096 49.47 µM -2.6571068572294 0.00217737732853194 no 3341 0.00394072284482361 1084 25236875
SGTC_2606 farnesol 9.78 µM -2.69827655944171 0.00189334662662516 no 3342 0.0034849755069412 1076 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3239 9133757 49.47 µM -2.71570306119818 0.00178360685814605 no 3343 0.00330676026716487 1094 17036923
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -2.76564079795739 0.00150041643237585 no 3344 0.00284055371275343 1089 17037758
SGTC_1497 4476-2978 41.3 µM -2.83065278619416 0.00119323317019687 no 3345 0.00232265593708147 1089 1528379
SGTC_2397 5161689 200 µM -2.92299843228612 0.00085512980696897 yes 3346 0.00173339130945923 1084 2259942
SGTC_1056 3448-1962 115 µM -2.99872784080782 0.000646259392183113 yes 3347 0.00135554681918257 1083 715507
SGTC_2517 totarol 10 µM -3.025833842544 0.000583743501412916 yes 3348 0.00123974258475687 1087 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_424 splitomicin 100 mM -3.20996521474424 0.000286391549092711 yes 3349 0.000663755181241767 1092 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2864 9034755 47.6 µM -3.33939472761805 0.000169837341077234 yes 3350 0.000419805835813611 1094 4930451
SGTC_1490 4089-0339 670 nM -3.64079534420576 4.68706475721701e-05 yes 3351 0.000135898562507176 1093 742542
SGTC_67 0335-0847 266 µM -3.7363585754862 3.05223226344316e-05 yes 3352 9.3352188719962e-05 1092 4552207 YOR254C SEC63
SGTC_2136 5328288 199.296 µM -3.84671265058692 1.83691869021348e-05 yes 3353 5.98566156443749e-05 1093 262395
SGTC_2349 9023730 187.07 µM -4.29782872386818 2.00458961763567e-06 yes 3354 8.62396777067387e-06 1094 4126287
SGTC_2343 7990716 14.84 µM -4.50937981566781 6.56447221819314e-07 yes 3355 3.25087075264951e-06 1093 6456862