SGTCid condition conc unit BOP3|YNL042W.score BOP3|YNL042W.strain.pval BOP3|YNL042W.strain.significant BOP3|YNL042W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_479 n-linoleoylglycine 10 µM 5.43313291618121 1.71703234806984e-09 yes 1 2.76865648001514e-08 2 6433346 An anti-infammatory. SGTC_1587 estradiol valerate 56.1 µM 3.74811072948819 2.19398124163425e-05 yes 2 8.90857987633846e-05 14 13791 A steroid. SGTC_477 mead ethanolamide 10 µM 3.74187750676494 2.25861308030519e-05 yes 3 9.13252723879022e-05 5 16061185 SGTC_1586 deoxycorticosterone acetate 53.7 µM 3.72195542962825 2.47750711932726e-05 yes 4 9.88429613196515e-05 16 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2514 salinomycin 42.74 µM 3.51796653494212 6.22717741662778e-05 yes 5 0.000217433599750562 71 23682228 A polyether potassium ionophore. SGTC_2942 9052777 62.25 µM 3.51730962573485 6.24521979223658e-05 yes 6 0.000217972469524111 51 6469503 SGTC_1756 st041558 35.5 µM 3.40273132658341 0.000102687444896506 yes 7 0.000333579255905791 19 3955792 SGTC_2110 5483698 200 µM 3.25323614872121 0.000192216932970034 yes 8 0.000570493162227791 46 2848765 YHR062C RPP1 SGTC_1763 st044482 94.5 µM 3.22106520018605 0.000219270291795602 yes 9 0.000638575447262871 39 88505 SGTC_406 estrone 100 µM 3.18217037663903 0.000256718715083837 yes 10 0.000730879002071126 29 5870 A steroid. SGTC_2076 5212012 200 µM 3.1708551231803 0.000268684645617876 yes 11 0.000759954629951587 17 604802 SGTC_1008 4106-0037 6 µM 3.14153777754335 0.000302148513744022 yes 12 0.000840315629244043 43 2905394 SGTC_2080 5212524 12.4 µM 2.98872003536073 0.000548641924448245 yes 13 0.00140074350666178 46 260183 SGTC_305 1682-2595 20.8 µM 2.94084681928089 0.00065789363923358 yes 14 0.0016365817670528 59 226033 SGTC_1330 1469-0054 61.8 µM 2.70412208449973 0.0015564772993199 no 15 0.00342425610746028 78 7102664 SGTC_2989 9073649 71.4286 µM 2.67358215902589 0.00173165023559637 no 16 0.00375229455582565 135 21367202 SGTC_485 niflumic acid 177 µM 2.63515588916077 0.00197748677602043 no 17 0.00420493248012733 62 4488 A COX2 inhibitor. SGTC_2823 7987624 58.44 µM 2.60967600237177 0.00215754288246725 no 18 0.00453140063432045 137 2239440 SGTC_322 k048-0136 19.3 µM 2.57787920263632 0.00240303341381566 no 19 0.00497043712418453 79 6823282 SGTC_3313 9133968 57.047 µM 2.56901121551524 0.00247586824893263 no 20 0.00509945782807598 71 1494643 SGTC_326 k292-0812 17.5 µM 2.56198817540322 0.00253496038639902 no 21 0.0052037430915262 57 3579357 SGTC_553 k007-0256 45.7 µM 2.56054923116172 0.0025472239596342 no 22 0.00522534276546886 116 6287000 SGTC_2100 5377183 190 µM 2.51951795679007 0.00292027873242104 no 23 0.00587578230659973 95 2844202 SGTC_1875 nocodazole 6 µM 2.49816183299274 0.00313333347219473 no 24 0.00624195939680949 124 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2957 9076800 11.52 µM 2.49411193843474 0.00317528015539365 no 25 0.00631363579292892 105 16459615 SGTC_1143 3454-2408 5.08 µM 2.49264203651013 0.00319062918288905 no 26 0.00633983026752418 51 X1143 SGTC_133 0724-0033 378.92 µM 2.46369328257844 0.00350684002296427 no 27 0.00687568652125545 103 280309 SGTC_281 1672-3440 14.9 µM 2.45643607928058 0.00359039989343836 no 28 0.00701613816384961 84 6833000 SGTC_280 3448-3607 3.04 µM 2.44864763080831 0.00368206076926526 no 29 0.00716968264684099 78 626179 SGTC_492 tmb-8 126 µM 2.43364870075889 0.00386451479748891 no 30 0.00747374716678441 44 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2516 gossypol 71.55 µM 2.43186528576582 0.00388673943738882 no 31 0.00751064652525001 125 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1044 1222-0021 1.78 µM 2.42665078177219 0.00395238020263548 no 32 0.00761945823705219 154 4306703 SGTC_3126 9127922 49.47 µM 2.42614120292984 0.00395884779628387 no 33 0.00763016576830269 158 45595682 SGTC_500 h-89 112 µM 2.40864845455816 0.00418669407281707 no 34 0.00800585640835233 137 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2034 5197015 53.07 µM 2.40032471102402 0.00429917569830092 no 35 0.00819026700658473 119 780676 SGTC_2055 5235184 200 µM 2.3589712230571 0.00489902649925955 no 36 0.00916283839470665 155 2836034 SGTC_3109 9122853 49.47 µM 2.35691399998497 0.00493072639415025 no 37 0.0092137569764379 101 1234709 SGTC_408 cantharidin 100 µM 2.32632522232329 0.00542411055286387 no 38 0.0100006037327041 159 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_697 0508-1955 564 µM 2.3236633970267 0.00546905290866141 no 39 0.0100717708492583 175 6243113 SGTC_2367 9070478 135.38 µM 2.31733670147842 0.00557720362317853 no 40 0.0102426987592875 169 572802 SGTC_480 am 92016 50 µM 2.30900336631892 0.0057225535417317 no 41 0.0104716972212409 117 2129 K+ channel blocker. SGTC_774 k060-0086 136 µM 2.30871084265414 0.00572771626514667 no 42 0.0104798161359314 164 5911235 SGTC_933 2914-0560 114 µM 2.29478859316565 0.00597825925564028 no 43 0.0108726213373186 173 463887 SGTC_1157 4092-0394 27.6 µM 2.28166213653578 0.0062233311568795 no 44 0.0112546475707774 178 3659885 SGTC_307 1501-1223 22.3 µM 2.2667408189486 0.00651268296101635 no 45 0.011703031642682 131 2830329 SGTC_3298 9116858 71.43 µM 2.25875355096094 0.00667240903762063 no 46 0.0119493596616936 142 2506942 SGTC_132 0417-1715 25.805 µM 2.24802593154247 0.00689237949638473 no 47 0.0122872682146845 143 6769098 SGTC_3103 9120822 49.47 µM 2.24614045109749 0.00693169620928418 no 48 0.0123475065276355 145 17141819 SGTC_2949 9072542 2.23 µM 2.24165507509163 0.00702602373831988 no 49 0.0124918367479693 207 16457352 SGTC_1041 0206-0046 107 µM 2.23748711046537 0.00711468973758687 no 50 0.01262726041384 157 50494 SGTC_257 daunorubicin 18.5 µM 2.23396960134399 0.00719028508024254 no 51 0.0127425366463086 108 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1012 4112-3522 18 µM 2.21260736866825 0.00766478205443794 no 52 0.0134623632879297 167 3112398 SGTC_2839 9003951 25.97 µM 2.20021223414034 0.00795255934526929 no 53 0.0138959203512481 136 2990634 SGTC_1748 st037455 53.6035 µM 2.18850462950371 0.00823305592407734 no 54 0.0143164322058778 198 580690 SGTC_1603 st002045 67.8 µM 2.18782223540575 0.00824966984442516 no 55 0.0143412767775256 146 5887985 SGTC_1316 1272-0050 65.9 µM 2.18629181055536 0.00828703747937126 no 56 0.0143971314554629 140 7340392 SGTC_2093 5331342 194.4 µM 2.17888006145742 0.00847011737040611 no 57 0.0146702896606526 154 33839 SGTC_3191 9110352 49.47 µM 2.16894822595164 0.00872100696802905 no 58 0.0150433074132779 140 17122424 SGTC_2272 7805186 180 µM 2.16007050399401 0.0089507596911964 no 59 0.01538360600376 128 2956062 YPR165W RHO1 SGTC_284 0988-0104 32.6 µM 2.15620221961655 0.00905251715943865 no 60 0.0155339391556 163 4666532 SGTC_597 k018-0003 82.8 µM 2.12928401464091 0.0097890870184129 no 61 0.0166153847687733 162 6786234 SGTC_1753 st043925 64 µM 2.12882088612767 0.00980220493317395 no 62 0.0166345411122363 168 670181 SGTC_1434 4073-0095 163 µM 2.08875666439842 0.010996716364324 no 63 0.0183648165930948 166 24133745 SGTC_873 0591-4978 488 µM 2.08193097846866 0.0112123772583563 no 64 0.0186743873423459 195 3305145 SGTC_1555 citronellol 128 µM 2.06972463422747 0.0116072191265911 no 65 0.0192390692538391 127 8842 A terpine precursor. SGTC_3168 9103419 49.47 µM 2.06684666685262 0.0117020533883003 no 66 0.0193743022763633 91 16649256 SGTC_1955 wogonin 32.4 µM 2.05800277952957 0.0119976964060048 no 67 0.0197949332919974 177 5281703 A flavanone. SGTC_3257 9139206 32.98 µM 2.04863400336683 0.0123179301060973 no 68 0.0202489585245999 126 4910041 SGTC_2242 6630449 61.2675 µM 2.03877027861901 0.0126630578892769 no 69 0.0207364799621347 214 691249 YDR170C SEC7 SGTC_32 0928-0142 34.1 µM 2.02980164688954 0.0129840991903938 no 70 0.0211883527514333 146 2244242 SGTC_686 1319-0111 510 µM 2.00972443701614 0.0137283874832996 no 71 0.0222301810487977 217 4562600 SGTC_366 0181-0206 4.31 µM 1.99873954075965 0.0141509797337953 no 72 0.0228182711934407 270 274874 SGTC_2974 9094440 9.66 µM 1.99689987834236 0.0142228369272403 no 73 0.022918030211429 263 25236134 SGTC_907 3448-6986 75.5 µM 1.99326120349979 0.0143658896101087 no 74 0.0231164261589168 252 590582 SGTC_2608 thymoquinone 42.66 µM 1.99110725546634 0.0144511534255582 no 75 0.0232345484875036 189 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_75 0159-0059 199.013 µM 1.97912731691969 0.0149333701043042 no 76 0.0239008367968656 215 5377270 SGTC_2511 berberine 10.47 µM 1.97825494034271 0.0149690191753964 no 77 0.0239499768010867 197 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_453 enantio-paf c16 10 µM 1.96978776726169 0.0153188417406738 no 78 0.0244313495629262 462 13871343 A lipid and platelet activating factor SGTC_27 0485-0001 32.618 µM 1.967232635905 0.0154257768753748 no 79 0.0245781985786396 136 2054479 SGTC_1602 st001878 87.6 µM 1.96152020358015 0.0156671688020422 no 80 0.024909185275167 216 595405 YLR310C CDC25 SGTC_2245 6637752 200 µM 1.94298922780897 0.0164726719926416 no 81 0.0260087299374644 168 681890 SGTC_1751 st044839 27.194 µM 1.94099802725307 0.0165612985963846 no 82 0.0261292583278661 188 5291326 SGTC_1793 st048256 72.231 µM 1.93742835120872 0.0167212035580597 no 83 0.026346501897029 176 672022 SGTC_2468 5987765 72.9 µM 1.93721665067094 0.0167307281107167 no 84 0.0263594328637285 216 26772094 SGTC_1491 4138-0063 26.5 µM 1.93656428047865 0.0167601078871936 no 85 0.026399313917095 174 23883227 SGTC_478 N-arachidonylglycine 10 µM 1.91712709957205 0.017655939135053 no 86 0.0276108933025693 118 5283389 SGTC_1270 0831-1170 17.3 µM 1.91639092265104 0.0176906566204 no 87 0.0276576776853278 237 6764716 SGTC_2793 7325131 81.82 µM 1.91010625285001 0.0179894147824519 no 88 0.0280597670435229 220 4176441 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.90908741857589 0.0180382507170544 no 89 0.0281254077433639 331 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2354 9060492 162 µM 1.90475834894295 0.0182470190370622 no 90 0.0284057451820324 267 6471895 SGTC_293 4049-0273 38.5 µM 1.89626435202977 0.0186626270908866 no 91 0.0289625487792287 212 1380311 SGTC_735 3076-0345 636 µM 1.89617510711995 0.0186670362336588 no 92 0.0289684468258947 303 2888990 SGTC_330 1488-0319 80.1 µM 1.88872192282359 0.0190384029185005 no 93 0.0294645497398498 235 6846614 SGTC_1370 2001-0092 44.6 µM 1.88818383188611 0.0190654556318431 no 94 0.0295006377953278 307 790957 SGTC_1035 k081-0041 55.2 µM 1.87430047638395 0.019774832174915 no 95 0.030444510955236 281 731709 SGTC_3223 9129970 49.47 µM 1.8706642199818 0.0199642886987505 no 96 0.0306958185700705 268 17248386 SGTC_357 1325-0123 420 µM 1.86536051420453 0.0202433825567266 no 97 0.0310654440738968 216 1098503 SGTC_745 0469-0705 296 µM 1.8609359103051 0.0204787402442826 no 98 0.0313766139198122 294 3486736 SGTC_1548 st061468 90.8 µM 1.84775108853295 0.0211938719665086 no 99 0.032319179788729 224 390799 SGTC_426 0988-0037 14.6 µM 1.845016637782 0.0213448012723933 no 100 0.0325175591978246 316 5383008 SGTC_2569 tetrandrine 100 µM 1.84265629880451 0.0214758111695722 no 101 0.0326896042003504 234 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1716 st033144 30.6155 µM 1.84036117919221 0.0216038522412236 no 102 0.0328576144543903 286 674617 SGTC_254 nsc-64875 3.808 µM 1.83986121570341 0.0216318298140835 no 103 0.0328943076728743 237 56993 SGTC_2081 5214970 32.255 µM 1.83515563587191 0.021896653673573 no 104 0.033241316193099 254 2063512 SGTC_1596 piperlongumine 63 µM 1.82727546657818 0.0223462695401081 no 105 0.0338291810138838 279 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2934 9036370 36.88 µM 1.8234094895535 0.0225696813434265 no 106 0.0341206970610726 310 6462800 SGTC_3215 9129942 49.47 µM 1.80844164326861 0.0234525004520488 no 107 0.0352688958017763 233 17682944 SGTC_1005 4092-0690 4.4 µM 1.78922084964599 0.0246286068940944 no 108 0.0367896275762354 282 1529343 SGTC_2279 7948423 32.93 µM 1.78395851143431 0.0249591033827773 no 109 0.0372152035085801 241 1247112 SGTC_2876 9059903 25.97 µM 1.77787296484408 0.0253459293401058 no 110 0.0377123606777591 275 6916095 SGTC_929 2805-0021 398 µM 1.77281286247228 0.0256713858064859 no 111 0.0381298606699663 286 3098024 SGTC_1811 st050069 61.5 µM 1.77149045547431 0.0257570148657255 no 112 0.0382395892332729 228 3877702 SGTC_3063 1327-0034 4 µM 1.76666421719242 0.0260715563150155 no 113 0.0386422396939156 287 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1262 0737-0114 49.6 µM 1.75237872108194 0.027021470076052 no 114 0.0398543539486031 349 765919 SGTC_2592 piperlongumine 83.33 µM 1.75114482544769 0.0271048561570274 no 115 0.0399604832917499 294 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2287 7945887 168.79 µM 1.74414713640781 0.0275818283701592 no 116 0.0405667182659867 291 1245853 SGTC_1831 st055328 12 µM 1.74199161692814 0.0277301535594416 no 117 0.0407549555783864 305 1103068 SGTC_938 3126-1755 342 µM 1.74163704505038 0.0277546158372248 no 118 0.0407859874247489 299 1777771 SGTC_2736 butenafine 14.65 µM 1.7385961816745 0.0279651473877968 no 119 0.0410529093213224 356 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3343 9148379 18.9835 µM 1.73758701330326 0.0280353095733345 no 120 0.0411418048840114 289 1955036 SGTC_3173 9105693 49.47 µM 1.73444368272651 0.0282547888728587 no 121 0.0414196950256307 333 17096658 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.73178051001264 0.0284418591611153 no 122 0.0416563247867376 300 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2106 5357045 167.29 µM 1.73096549269272 0.0284993142670183 no 123 0.041728959623476 323 668842 SGTC_2724 maprotiline 69.64 µM 1.72571373820257 0.0288718596663678 no 124 0.0421994626189769 278 4011 A tricyclic antidepressant. SGTC_2798 7813637 45.45 µM 1.72232177228993 0.0291146215800438 no 125 0.042505622897115 334 956368 SGTC_742 0kpi-0133 140 µM 1.72117996941045 0.029196720595804 no 126 0.0426090857157862 323 2728852 SGTC_76 0433-0009 400.328 µM 1.72030000187987 0.0292601240074653 no 127 0.0426889615607074 254 2841569 SGTC_328 k915-0120 63.5 µM 1.71361562860952 0.0297454893106745 no 128 0.0432996706705209 314 6624543 SGTC_963 1269-2853 151 µM 1.71173402762055 0.02988331465437 no 129 0.0434728473776796 314 3668223 SGTC_1347 1493-0251 600 nM 1.71067091557668 0.0299614204330573 no 130 0.0435709398260226 327 3986378 SGTC_73 0327-0325 16.231 µM 1.70743848559373 0.0301999444287367 no 131 0.0438702911165127 386 53298 SGTC_2394 5221648 200 µM 1.70708859712814 0.0302258571697666 no 132 0.0439027931127679 373 788586 SGTC_1906 st060206 94.7 µM 1.70667428032651 0.0302565653023548 no 133 0.0439413051273648 336 5133468 SGTC_1360 1598-0022 39.8 µM 1.70281842641983 0.0305435935502473 no 134 0.0443010267100122 400 761525 SGTC_2580 diallyl disulphide 81.36 µM 1.70009936687587 0.030747352306631 no 135 0.0445561181848429 314 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3309 9129340 25.759 µM 1.69775163330564 0.0309241890996263 no 136 0.0447773240260394 330 17158987 SGTC_713 1488-1073 324 µM 1.6975282639483 0.0309410575670025 no 137 0.0447984161033143 282 3312542 SGTC_699 0375-0592 111 µM 1.69135796306641 0.0314100469470673 no 138 0.0453842279068579 300 762578 SGTC_2316 5844804 197.44 µM 1.68823547112027 0.031649610476053 no 139 0.0456830183326951 434 776813 SGTC_2644 guaiazulene 100 µM 1.68495150511853 0.0319031896282298 no 140 0.045998964112638 284 3515 A coloring agent. SGTC_2976 9009005 19.48 µM 1.67875998042657 0.032385847052371 no 141 0.0465994154903642 329 2993148 SGTC_507 nimesulide 162 µM 1.67646883731905 0.03256597250095 no 142 0.0468231976230935 327 4495 A COX2 inhibitor. SGTC_2046 4110841 106 µM 1.67396204197016 0.0327639979501078 no 143 0.0470690297809907 320 44119630 YMR134W ERG29 SGTC_2944 9067346 25.62 µM 1.67073773803229 0.0330201619397957 no 144 0.0473867456661478 365 6473075 SGTC_822 1487-0950 154 µM 1.65895647168826 0.0339702271520629 no 145 0.0485622819363334 329 1958375 SGTC_859 0439-0102 54.6 µM 1.65752555847658 0.0340871349644542 no 146 0.0487066329766537 359 610143 SGTC_1779 st039427 55 µM 1.65292036410015 0.0344656339528378 no 147 0.049173536027412 410 1124498 SGTC_1688 st021091 57.6 µM 1.65052169824092 0.0346641428883794 no 148 0.0494181395607381 297 3656366 SGTC_2605 digitonin 300 nM 1.62060234275996 0.0372200240708061 no 149 0.0525514747408469 423 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2975 9084847 53.72 µM 1.61962602995055 0.0373059535550288 no 150 0.0526563172781061 374 27211724 SGTC_1031 k035-0009 16 µM 1.61855105692606 0.0374007539395768 no 151 0.0527719464799996 397 5180959 SGTC_1652 st011932 78 µM 1.61577198544115 0.0376467485585007 no 152 0.0530718103024496 331 1551076 SGTC_2722 naftopidil 47.16 µM 1.60657057061414 0.0384706707392781 no 153 0.0540743013106741 361 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2568 diosmetin 100 µM 1.60493598716651 0.0386185623637663 no 154 0.0542539463903796 390 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1365 1672-3266 55.4 µM 1.60175263045145 0.038907911354282 no 155 0.0546051608853288 392 6415873 SGTC_400 oxethazaine 37.5 µM 1.60155602675689 0.0389258392406934 no 156 0.0546269106551584 347 4621 A local anesthetic. SGTC_1591 genipin 88.4 µM 1.59610472878356 0.0394256168852739 no 157 0.0552327065516368 316 442424 A DNA cross-linking agent. SGTC_2107 5363541 170.161 µM 1.59559237055867 0.0394728573097444 no 158 0.0552899160091212 374 244052 SGTC_3160 9100216 49.47 µM 1.5951456392204 0.0395140843747223 no 159 0.0553398358097241 345 17191039 SGTC_692 k241-0027 77.8 µM 1.59317444695313 0.0396964163232163 no 160 0.0555605309835236 353 3600480 SGTC_2133 5320837 200 µM 1.59229039143071 0.0397784118758389 no 161 0.055659735456732 366 2841355 SGTC_548 1436-0017 110 µM 1.59044732198839 0.0399497980909443 no 162 0.0558670053757712 447 9677137 SGTC_1315 1237-0019 3.69 µM 1.58765152875883 0.0402109228385952 no 163 0.0561825796506125 367 825140 SGTC_508 roscovitine 141 µM 1.58337975733844 0.0406125786397765 no 164 0.0566674669848459 324 160355 A CDKinase inhibitor. SGTC_1755 st041960 45.185 µM 1.58017921166053 0.0409156407505557 no 165 0.0570329155474456 367 2257073 SGTC_1605 st000082 49.1 µM 1.57625122058364 0.0412900898282457 no 166 0.0574839592285853 350 1114022 SGTC_1590 st077108 57.8 µM 1.57376425326391 0.0415286012221652 no 167 0.0577709805391845 349 5489485 SGTC_2050 5263056 171 µM 1.57217596225756 0.0416815087547804 no 168 0.0579548742662008 450 763468 YGL055W OLE1 SGTC_3032 9089427 49.47 µM 1.57036356659909 0.0418565479783929 no 169 0.0581652767211624 351 17173707 SGTC_2889 9059656 51.95 µM 1.56848350879505 0.0420387503997454 no 170 0.0583841678251569 405 3949838 SGTC_2591 skatole 100 µM 1.56713266688283 0.0421700607536433 no 171 0.0585418424846878 376 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2217 6934799 96.0675 µM 1.56684487792066 0.0421980784997508 no 172 0.0585754773102981 349 675606 SGTC_455 paf C-16 10 µM 1.56280835277471 0.0425926446894649 no 173 0.0590488394746659 366 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1973 st070275 50.2 µM 1.54831754744827 0.0440337446727793 no 174 0.0607729308549488 360 17118334 SGTC_2925 9010536 32.5 µM 1.54744132185939 0.0441221301955401 no 175 0.0608784317797412 475 2994177 SGTC_152 4469-0003 551.229 µM 1.54602853221018 0.0442649405098022 no 176 0.0610488385966152 372 697280 SGTC_2006 4011487 200 µM 1.54054824694097 0.0448224383834117 no 177 0.0617133859280148 458 45595294 SGTC_2180 6301957 200 µM 1.5372207230802 0.0451636896880019 no 178 0.0621196336352575 355 845462 SGTC_1715 st032160 10.2275 µM 1.53688971394458 0.0451977500571995 no 179 0.0621601594055663 391 5289825 SGTC_2941 9056145 11.23 µM 1.52899433365873 0.0460163166817867 no 180 0.0631329243183643 316 2119517 SGTC_1381 2324-0066 62.1 µM 1.5280196304375 0.046118191372247 no 181 0.0632538320563534 421 10885928 SGTC_739 1486-1183 203 µM 1.52505001895505 0.0464296883307732 no 182 0.0636233111206928 409 4346692 SGTC_759 3486-0358 89.3 µM 1.52354001564505 0.0465887264037939 no 183 0.0638118286628697 450 875103 SGTC_54 0159-0055 9 µM 1.51432223570828 0.0475690724606605 no 184 0.0649720658234746 412 3319099 SGTC_1745 st081495 74 µM 1.5079684923014 0.0482543872604364 no 185 0.0657812955993968 482 13842402 YBL026W LSM2 SGTC_1507 4075-3230 155 µM 1.50675016067746 0.0483866946398354 no 186 0.0659373544457535 348 659771 SGTC_2421 5690543 90.72 µM 1.50648674273829 0.0484153391987914 no 187 0.065971133934758 412 3397993 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.50428286416005 0.0486555247875794 no 188 0.0662542746771701 508 551469 SGTC_300 r073-0011 5.04 µM 1.49904722406321 0.0492299411825567 no 189 0.0669306907210379 481 2735780 SGTC_2546 rhodinyl acetate 100 µM 1.49679486046806 0.0494787142840844 no 190 0.0672233220154742 425 6708682 SGTC_676 falcarinol 140 µM 1.49629195962095 0.0495343963829158 no 191 0.0672887947257243 455 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2487 5918373 44.05 µM 1.48735845668212 0.0505318896844745 no 192 0.0684600814403356 429 2876279 SGTC_2878 9043973 25.97 µM 1.48623797392138 0.0506581216102325 no 193 0.0686080932360563 380 6465167 SGTC_689 0833-0039 98 µM 1.48609575279928 0.0506741619774861 no 194 0.0686268977799902 429 5374726 SGTC_884 0851-0618 334 µM 1.48535679858182 0.0507575698313383 no 195 0.0687246666455354 457 9642473 SGTC_1283 0922-0125 16.4 µM 1.48487508219768 0.0508120013596199 no 196 0.0687884589348858 478 3360884 SGTC_360 0957-0399 1.01 µM 1.48052744379192 0.0513053678398365 no 197 0.0693662711765135 460 6752301 YPR165W RHO1 SGTC_1145 3546-0597 10.2 µM 1.47707946772412 0.0516993446582864 no 198 0.0698271683260722 455 875334 SGTC_134 0269-0018 6.916 µM 1.47655769315323 0.0517591732505037 no 199 0.0698971197151112 508 4378915 SGTC_1880 MG-132 525 µM 1.47443495189623 0.0520031421397091 no 200 0.0701822597947609 391 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2564 betulinic acid 100 µM 1.47284782251468 0.0521861488232148 no 201 0.0703960369974555 489 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1624 st003710 6.25 µM 1.47108129894011 0.0523904419636783 no 202 0.0706345659259722 501 24207033 SGTC_725 1497-0963 19 µM 1.46800897750826 0.0527472586295089 no 203 0.0710508921676727 426 3549977 SGTC_1563 conessine 56.1 µM 1.46691674494494 0.0528745731387258 no 204 0.0711993523816934 525 441082 An anti-amoebic, histamine inhibitor. SGTC_2086 5274770 176.623 µM 1.46672938467771 0.052896436990319 no 205 0.071224842983889 426 689278 SGTC_2962 9082311 13.18 µM 1.46622238906533 0.0529556363831285 no 206 0.0712938555127075 412 16459453 SGTC_2393 9031399 185.94 µM 1.46213924569833 0.053434322739386 no 207 0.071851528046012 445 1526623 YDL150W RPC53 SGTC_2606 farnesol 9.78 µM 1.46003503063637 0.0536823452728595 no 208 0.0721402233001739 455 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2909 7941780 10.49 µM 1.45175352327133 0.0546673488416315 no 209 0.0732850755556761 451 1243215 SGTC_812 4251-0442 148 µM 1.44729650667589 0.0552033513082256 no 210 0.0739069485545895 413 5723007 SGTC_279 1273-0055 2.93 µM 1.44342927958012 0.0556717814037837 no 211 0.0744497905078938 493 2847562 SGTC_3353 9151644 39.2805 µM 1.44332011066189 0.0556850502213202 no 212 0.0744651585874663 459 4909158 SGTC_1783 st039459 87.517 µM 1.44110964018241 0.0559542567179581 no 213 0.0747768552476034 503 729761 SGTC_1210 3013-0140 750 nM 1.44003730325651 0.0560852226729537 no 214 0.0749284227586859 472 905973 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.43884760543872 0.0562308048218732 no 215 0.0750968525273216 479 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1191 1487-1166 10.6 µM 1.43781052084168 0.05635795475607 no 216 0.0752439117015116 533 3955771 SGTC_743 1275-0778 158 µM 1.43401817302956 0.0568248393815309 no 217 0.0757835384418783 485 2849257 YMR203W TOM40 SGTC_827 3253-0474 693 µM 1.43211366483943 0.0570604540135264 no 218 0.0760556471771257 486 5402065 SGTC_1312 1218-2183 165 µM 1.43203228638107 0.0570705387888592 no 219 0.0760672907641907 465 6744073 SGTC_1333 1482-0047 286 µM 1.43173562994885 0.0571073136354766 no 220 0.0761097477010194 497 3811116 SGTC_457 grayanotoxin iii 135 µM 1.42760789657085 0.0576209435174944 no 221 0.0767023747324152 549 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_260 nsc-65238 3.989 µM 1.42753747652623 0.0576297375729847 no 222 0.0767125154374586 448 3246252 SGTC_2103 5378138 10 µM 1.42368881825464 0.0581119652567045 no 223 0.0772682859971175 516 244142 SGTC_3266 9136860 49.47 µM 1.42020659711693 0.0585510062119391 no 224 0.0777737718079802 480 4871271 YPR165W RHO1 SGTC_3048 9093155 49.47 µM 1.41399877020891 0.0593401486763056 no 225 0.0786811317832457 394 25236002 SGTC_1815 st051655 58.2 µM 1.40658670871452 0.0602932691181067 no 226 0.0797749882883495 431 5984156 SGTC_667 1498-1044 59 µM 1.40612773577083 0.0603526803619314 no 227 0.0798430988587018 470 6739982 SGTC_1435 4092-0789 56.7 µM 1.3981983677799 0.061386337887498 no 228 0.0810267533981226 465 2248285 SGTC_1817 st052116 64.4 µM 1.39477274096515 0.0618371518915135 no 229 0.0815421907283189 462 4361398 SGTC_2009 4012297 12.05 µM 1.38752717738522 0.0627991813285338 no 230 0.0826405349247668 478 45595307 SGTC_1679 SEC14.276 6.7 µM 1.38682627386043 0.0628928590260579 no 231 0.0827473716892578 569 1005053 YMR079W SEC14 SGTC_1058 3448-5425 97.3 µM 1.38393036910335 0.0632810592886721 no 232 0.0831898883461409 474 7279705 SGTC_3165 9101544 49.47 µM 1.38305278200149 0.0633990687135951 no 233 0.0833243411501783 506 5002184 SGTC_643 k048-0106 28.4 µM 1.37932566155496 0.0639021653785239 no 234 0.0838971839740726 496 6763920 SGTC_1978 st071761 42 µM 1.37926236584856 0.0639107359352994 no 235 0.0839069377352875 453 5147680 SGTC_621 3584-0052 32.1 µM 1.37846390133629 0.064018928825223 no 236 0.0840300529034508 511 2273927 SGTC_1672 st016598 6.51 µM 1.37710430059103 0.0642034839785523 no 237 0.0842400016396364 514 4665860 YNL267W PIK1 SGTC_1657 st012939 43.4 µM 1.37497057452744 0.0644939540236261 no 238 0.0845702837527755 449 24207257 SGTC_306 1672-3436 11.6 µM 1.37320486184926 0.0647350965188259 no 239 0.0848443343429636 503 6797378 SGTC_1508 1080-0625 72.9 µM 1.37123755360851 0.065004594821124 no 240 0.0851504575321121 450 767111 SGTC_475 α-linolenic acid 10 µM 1.36212327790925 0.0662645215830004 no 241 0.0865794915921767 524 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_130 0136-0219 337.655 µM 1.36021272922238 0.0665310115193238 no 242 0.0868813077792297 505 234244 SGTC_1553 gossypol 38.6 µM 1.35964740679448 0.0666100234953101 no 243 0.0869707643102519 361 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2123 5259487 200 µM 1.35795892414441 0.066846445770924 no 244 0.0872383591676339 536 2173474 SGTC_687 k029-0044 34.9 µM 1.35715673740915 0.0669589956482162 no 245 0.0873657068847487 522 5829338 SGTC_2216 7189485 200 µM 1.35371269750602 0.0674438739508143 no 246 0.087914027782648 484 731273 SGTC_2179 6298986 200 µM 1.35258538001094 0.0676031744601984 no 247 0.0880940628303937 455 738374 SGTC_1692 fluoroquinolonic acid 71 µM 1.34753902828237 0.0683198368339166 no 248 0.0889033462535681 470 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1788 fluconazole 20 µM 1.34542858612318 0.0686212861641168 no 249 0.0892434344736505 503 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1486 3970-0793 4.53 µM 1.3406437763016 0.0693085328726462 no 250 0.0900180685047456 512 2844330 SGTC_2271 7849410 118.62 µM 1.33528178629183 0.0700849671029574 no 251 0.0908920687593142 500 972430 SGTC_2438 5259590 200 µM 1.33128438850542 0.0706681444949598 no 252 0.0915477265314381 537 1201127 SGTC_1100 amiodarone 5.07 µM 1.33080552865822 0.070738254396404 no 253 0.0916265041630122 550 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1334 1486-0610 236 µM 1.3229569379485 0.0718949982321729 no 254 0.0929248493280996 535 3742339 SGTC_2851 9015922 71.43 µM 1.32249166768753 0.0719640236289285 no 255 0.09300224107348 538 2996893 SGTC_3342 9147791 14.508 µM 1.3209537163313 0.0721925487639487 no 256 0.0932583986080805 527 1838168 SGTC_2636 apigenin dimethyl ether 100 µM 1.31838535136446 0.0725754231526372 no 257 0.0936873409921658 568 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3049 9092223 49.47 µM 1.31617333429423 0.0729064205354504 no 258 0.0940579357849142 512 8623917 SGTC_2045 5106652 78.05 µM 1.30452269783283 0.0746688761259181 no 259 0.0960277128487161 518 673349 SGTC_2310 7668677 200 µM 1.30255353082643 0.0749699484100824 no 260 0.0963636155924628 537 2197143 SGTC_2239 6685329 187.64 µM 1.30217766286653 0.0750275211645879 no 261 0.0964278295958512 549 805680 SGTC_1198 1612-1005 86.7 µM 1.30193022768677 0.0750654399095463 no 262 0.0964701190556677 564 6998509 SGTC_2134 5324836 1.464 µM 1.29979659060444 0.0753930203865873 no 263 0.0968353471762887 471 699272 SGTC_910 3454-3003 490 µM 1.29532946022258 0.076082392732487 no 264 0.0976033002593379 587 820824 SGTC_2078 5212016 200 µM 1.29107872505599 0.0767428163253881 no 265 0.0983381902296327 490 1899708 SGTC_2386 9075165 157.42 µM 1.29061498365212 0.0768151293106079 no 266 0.0984186088502968 523 16452277 SGTC_2338 7999974 200 µM 1.28992853179906 0.0769222654780915 no 267 0.0985377366619546 603 315925 SGTC_1239 0337-0584 35.4 µM 1.28814603917067 0.0772009937163146 no 268 0.0988475658097597 609 914301 YML130C ERO1 SGTC_2786 7743617 45.45 µM 1.28655632466795 0.0774502240221779 no 269 0.0991244874902422 477 583674 SGTC_1552 6-methylflavone 10.6 µM 1.28574517457046 0.0775776287255607 no 270 0.0992660048967072 487 689013 SGTC_3028 9087778 49.47 µM 1.28516348201974 0.0776690912104344 no 271 0.099367580878316 523 17217395 SGTC_3323 9138564 53.9225 µM 1.28416658109456 0.0778260293579048 no 272 0.0995418377987081 612 43912313 YNL103W MET4 SGTC_2911 7942208 15.64 µM 1.28316871625562 0.0779833601552384 no 273 0.0997164867580592 496 1243384 SGTC_2575 plumbagin 510 nM 1.2739085585121 0.0794549152632492 no 274 0.101347912456575 539 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1954 st077032 68.9 µM 1.27386797922834 0.0794614097501752 no 275 0.101355104127138 510 698907 SGTC_3259 9138485 49.47 µM 1.26979809123378 0.0801148152765709 no 276 0.102078280411974 621 17646153 SGTC_1520 flindersine 88 µM 1.26823643258895 0.0803666092339815 no 277 0.102356765048449 591 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_691 1548-0686 185 µM 1.26492677862057 0.0809022170057982 no 278 0.102948788461025 589 46495133 SGTC_1561 5-methoxyflavone 52.9 µM 1.26306869568493 0.081204092944007 no 279 0.103282246477046 495 94525 SGTC_255 tunicamycin 200.472 nM 1.26167115036844 0.0814317064651347 no 280 0.103533571053027 595 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3354 9151612 71.43 µM 1.25390525393017 0.0827052855815262 no 281 0.104938222574466 620 27261949 SGTC_123 0083-0120 66.675 µM 1.24925334353312 0.083475328066789 no 282 0.105786213436075 609 16001701 SGTC_1675 st018485 24.5 µM 1.24854151522597 0.0835936326008431 no 283 0.105916407459377 579 3323024 SGTC_988 1497-1057 103 µM 1.24783315654307 0.0837114855082029 no 284 0.106046081801299 585 3533044 SGTC_3197 9113331 49.47 µM 1.24615316296588 0.0839914928020061 no 285 0.106354085197986 587 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2618 avocadyne 43.43 µM 1.2440909850803 0.0843361601099111 no 286 0.106733039265567 564 3015189 SGTC_1405 3909-7894 12 µM 1.24326534767804 0.0844744522515785 no 287 0.106885034548707 585 7104060 SGTC_1490 4089-0339 670 nM 1.24289991683238 0.0845357152647033 no 288 0.106952358180161 551 742542 SGTC_2124 5246320 200 µM 1.24267928825902 0.0845727188908706 no 289 0.106993019574241 577 579342 SGTC_536 3852-0578 10.6 µM 1.23633549518324 0.0856418981700735 no 290 0.108166941182095 595 2869208 SGTC_757 1066-0008 322 µM 1.23448928013618 0.0859549514381952 no 291 0.108510319415032 628 6842497 SGTC_2357 9067248 200 µM 1.23263223471701 0.0862707042299365 no 292 0.108856502398783 553 9150235 SGTC_3226 9131256 49.47 µM 1.23120623367307 0.0865137549234746 no 293 0.109122870274278 465 17178073 SGTC_213 1246-0773 967 nM 1.2301288458431 0.0866977264475741 no 294 0.109324429831976 624 6251622 SGTC_1200 1643-0193 18.4 µM 1.22703564590581 0.0872275365739006 no 295 0.109904596786589 631 5403974 SGTC_1141 3253-0389 52.6 µM 1.22250067651487 0.0880086610504378 no 296 0.110759174106441 582 5402031 SGTC_534 k292-0788 63.4 µM 1.22100172044054 0.0882679918419823 no 297 0.111042684195995 664 4146317 SGTC_2224 6650123 117.647 µM 1.21986996454539 0.0884641712441975 no 298 0.111257086733665 556 2908370 SGTC_1498 4478-3555 97.6 µM 1.21851475424282 0.0886995115775191 no 299 0.111514210725111 545 3437919 SGTC_2843 9000894 45.46 µM 1.21518923994961 0.0892789823400229 no 300 0.112146961682619 459 2242070 SGTC_1825 st052143 62.6 µM 1.21363519670397 0.0895507379806845 no 301 0.112443530222737 565 674173 SGTC_668 1682-0499 62.6 µM 1.21238430690903 0.0897699276323537 no 302 0.112682652629153 653 682214 SGTC_2991 9074669 71.4286 µM 1.20993543007015 0.0902001911643785 no 303 0.113151835324663 683 17333109 SGTC_640 3381-0960 37.1 µM 1.20729245926253 0.0906662734220878 no 304 0.113659766845327 659 1745025 SGTC_3018 9082602 49.47 µM 1.2042101988424 0.091212078513415 no 305 0.114254172509224 655 17332089 SGTC_2480 5767542 37.17 µM 1.19538373399912 0.0927885377254171 no 306 0.115968568951755 633 2867358 SGTC_539 4859-0462 2.54 µM 1.19464113392609 0.0929220837762027 no 307 0.116113635379233 623 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1554 st069299 38.7 µM 1.19011770863505 0.093738627667438 no 308 0.117000065483505 628 24207999 SGTC_760 0568-0725 82.9 µM 1.1900527705858 0.0937503883734683 no 309 0.117012825846878 666 3916171 SGTC_3080 9117754 49.47 µM 1.1869022711362 0.0943222736173121 no 310 0.117633085696958 694 9550191 SGTC_52 0329-0193 875 nM 1.18483743574462 0.0946984800106251 no 311 0.118040864008642 622 3739292 SGTC_1386 3228-0095 33.8 µM 1.18480718442565 0.0947039999119596 no 312 0.118046845675689 615 870181 SGTC_2458 5808907 16.39 µM 1.18409768326594 0.0948335292649314 no 313 0.118187198555639 679 2731747 SGTC_1499 4480-0877 67.3 µM 1.18210319800315 0.0951983496230197 no 314 0.118582377817373 584 2861909 SGTC_431 k089-0097 107 µM 1.18187817574635 0.095239574254538 no 315 0.118627021365236 700 5499420 SGTC_1966 st070145 16.1 µM 1.18083367096641 0.0954311022284648 no 316 0.11883440258341 624 3748532 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.175705420774 0.0963755696011896 no 317 0.119856305852691 622 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2048 5246248 200 µM 1.17445954158035 0.0966060561956675 no 318 0.120105504114536 604 677046 SGTC_2373 9071805 200 µM 1.17425125981724 0.0966446276165141 no 319 0.120147199812503 642 10149009 SGTC_182 3448-4371 550.524 µM 1.17264712004023 0.0969420752315299 no 320 0.120468672611626 677 3491403 SGTC_2990 9074105 71.4286 µM 1.16963104379987 0.097503149931725 no 321 0.121074739429479 598 6502001 SGTC_1115 galangin 695.678 nM 1.1670507463881 0.097985044868152 no 322 0.121594938357149 705 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_716 1683-5115 658 µM 1.16581939446452 0.0982156256972849 no 323 0.121843737041395 739 723597 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.16247683660364 0.0988435507212673 no 324 0.122520914141548 736 5024745 SGTC_1138 3761-0006 1.03 µM 1.1620609675015 0.0989218799171353 no 325 0.12260535045147 654 12061087 SGTC_224 benfluorex 43.875 µM 1.16150858510117 0.0990259916824729 no 326 0.12271756695793 567 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2232 chlorophetanol 41.5365 µM 1.15466683707647 0.10032215877636 no 327 0.124113442458048 791 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1924 st058459 75.1 µM 1.15186243670692 0.100857014245618 no 328 0.124688803036202 634 688683 SGTC_2642 cholecalciferol 100 µM 1.14990854960421 0.1012308867309 no 329 0.125090769580752 638 9821465 A vitamin D precursor, similar to steriods. SGTC_2427 5545055 42.75 µM 1.14820107168848 0.101558435303861 no 330 0.125442783488143 716 5372858 SGTC_862 0452-0056 10.2 µM 1.14807444472573 0.101582757089 no 331 0.125468916433016 644 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3209 9113616 49.47 µM 1.14568352331964 0.102042788058705 no 332 0.125963061897369 710 16649353 SGTC_501 nsc-95397 161 µM 1.14523762664835 0.102128749328502 no 333 0.126055367861056 641 262093 SGTC_1760 st045453 10.4495 µM 1.13702486645777 0.10372146109895 no 334 0.127763945305875 698 3323419 YIL048W NEO1 SGTC_1000 4048-0884 8.67 µM 1.13624923816072 0.103872805917212 no 335 0.127926134413678 670 13040088 SGTC_1659 st012954 42.1 µM 1.13254118937422 0.104598554021207 no 336 0.12870348889505 664 24207262 SGTC_2629 bisabolol 100 µM 1.12986029598408 0.105125547868098 no 337 0.129267548180995 714 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1620 st003704 16.5 µM 1.12588938116954 0.105909653100987 no 338 0.13010617230291 701 2834414 SGTC_1368 1852-0141 284 µM 1.1253050923466 0.106025383796569 no 339 0.130229886286983 654 2838987 SGTC_1142 3253-1408 9.78 µM 1.12351890685321 0.106379742001761 no 340 0.130608587654217 665 256655 SGTC_897 1000-0139 31.4 µM 1.11948681281001 0.10718280454614 no 341 0.131466256824566 689 6151020 SGTC_828 2074-0507 139 µM 1.11873579273198 0.107332865107173 no 342 0.131626435322455 710 X828 SGTC_987 1497-1013 404 µM 1.11705391816088 0.10766946799877 no 343 0.131985636030923 655 1676435 SGTC_2624 nerol 100 µM 1.11497397948562 0.108086788654349 no 344 0.132430786177489 668 637566 A natural product oil. SGTC_3014 9081533 49.47 µM 1.1145708012921 0.108167817230763 no 345 0.132517194272098 720 21367265 SGTC_2159 5658611 73.75 µM 1.11416906089545 0.108248600329691 no 346 0.132603332852323 686 793844 SGTC_3328 9140624 29.0385 µM 1.11381340455008 0.108320152945733 no 347 0.132679622570759 714 4904392 SGTC_1956 st077085 54 µM 1.11295363162216 0.108493266686225 no 348 0.132864172189222 734 24208685 SGTC_31 0508-1974 57.237 µM 1.11291302789279 0.108501447093548 no 349 0.13287289211815 679 6810525 SGTC_2254 7938975 95.19 µM 1.11245086380202 0.108594590267982 no 350 0.132972172790732 781 2969277 SGTC_2553 4-methylesculetin 85.09 µM 1.11180672936432 0.108724503124083 no 351 0.133110628944927 687 5319502 SGTC_367 0335-0881 7.1 µM 1.11140844396483 0.108804887585178 no 352 0.133196289682913 716 23828853 SGTC_3297 9117502 71.43 µM 1.11096240262394 0.108894961166184 no 353 0.133292266491644 694 7453720 SGTC_25 0118-0223 35.662 µM 1.10962498571816 0.10916536042952 no 354 0.133580329948106 702 5333628 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.10925357097603 0.109240538675864 no 355 0.133660404095952 747 6708784 An antioxidant flavonoid SGTC_1720 st037298 9.481 µM 1.10886066930607 0.109320106581985 no 356 0.133745146574813 664 597396 SGTC_2372 9071633 200 µM 1.10680230278943 0.109737634085304 no 357 0.134189706206428 768 21321366 SGTC_365 0121-0052 13.6 µM 1.10582319815967 0.109936640946582 no 358 0.134401526032381 756 3101739 SGTC_2978 9011784 42.97 µM 1.10466931906569 0.110171503686962 no 359 0.134651451189955 815 2994934 SGTC_99 0109-0120 622.8 µM 1.10383754247839 0.110341028152355 no 360 0.134831808066103 658 759414 SGTC_606 k015-0008 38.6 µM 1.10327738889114 0.110455298459257 no 361 0.134953361376917 776 1970475 SGTC_2176 5809774 33.9695 µM 1.10316991351636 0.110477232936438 no 362 0.134976692121577 748 2870539 SGTC_1162 k048-0130 20.1 µM 1.10215717499377 0.110684074481348 no 363 0.135196673165624 702 6797406 SGTC_1177 0983-0204 23.6 µM 1.10137151425535 0.110844728753343 no 364 0.135367498945412 757 766818 SGTC_1810 st050138 53 µM 1.10066145387947 0.110990067698081 no 365 0.135522014199749 667 3444541 SGTC_1780 st038448 24.544 µM 1.09771056137484 0.111595534374673 no 366 0.136165448259266 706 728868 YDL195W SEC31 SGTC_2231 micatex 6.853 µM 1.09731061685238 0.11167777684112 no 367 0.136252815689829 673 20737 An antifungal of unknown mechanism. SGTC_1885 st057546 99.9 µM 1.09587135004183 0.11197409877934 no 368 0.136567539258999 737 702008 SGTC_2437 5741531 144.16 µM 1.0932856738285 0.112507859372643 no 369 0.13713419547936 752 2262990 SGTC_555 4296-0685 37 µM 1.08916056552989 0.113363163065616 no 370 0.138041542705598 728 2908540 YHR072W ERG7 SGTC_2306 7482397 179.52 µM 1.08832435442081 0.113537107694287 no 371 0.138225971325413 711 891448 SGTC_3201 9113999 49.47 µM 1.08816872016189 0.113569502982083 no 372 0.138260315415862 694 16649224 SGTC_587 k089-0003 57 µM 1.0879721465139 0.113610429226155 no 373 0.138303701987898 570 9659696 SGTC_1117 retinoic acid 1.10837 µM 1.08792261977455 0.113620742253271 no 374 0.13831463470022 780 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2222 6885208 172.143 µM 1.08742451317524 0.113724500848597 no 375 0.138424621316041 691 609514 SGTC_2228 7354201 200 µM 1.0852928822449 0.114169295302914 no 376 0.138895978685055 711 753451 SGTC_2226 7298446 200 µM 1.07981370372564 0.115318283911577 no 377 0.140112573778938 677 3283010 SGTC_2208 7283366 200 µM 1.07963074311913 0.11535679220878 no 378 0.140153322819375 745 898663 SGTC_2227 7312221 64.1025 µM 1.07861475984523 0.115570795706987 no 379 0.140379749385909 731 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2813 7971799 71.43 µM 1.07834320453384 0.115628042996685 no 380 0.140440311459791 701 2234054 SGTC_2375 9072683 200 µM 1.07697425468814 0.115916941656805 no 381 0.140745883786593 809 16798029 SGTC_1946 st076057 65.1 µM 1.07599831471366 0.116123213490088 no 382 0.140964005057241 594 953009 SGTC_1420 4'-methoxyflavone 42 µM 1.0715140340224 0.117074346426043 no 383 0.141969181946875 744 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1883 5-benzylidenerhodanine 20 µM 1.07060979655716 0.117266805489991 no 384 0.142172458354602 780 1273210 SGTC_1055 3448-0672 86 µM 1.07023838065095 0.117345923021731 no 385 0.142256011264162 716 748378 SGTC_876 0720-0963 56.8 µM 1.07013522886122 0.117367902709533 no 386 0.142279221959036 773 765861 SGTC_2049 5262831 67.185 µM 1.06841135365734 0.117735659352226 no 387 0.142667498903697 730 763417 SGTC_2247 cerulenin 830 nM 1.06728997777657 0.11797532134561 no 388 0.14292045618537 739 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_3267 9137951 49.47 µM 1.06587913156444 0.118277339304348 no 389 0.143239141813743 696 16643986 SGTC_2716 st080858 38.6235 µM 1.06582233940042 0.118289508161725 no 390 0.143251980216961 760 5296050 SGTC_1856 st057054 55.7 µM 1.06533768870525 0.118393390278435 no 391 0.143361571682275 774 1266018 SGTC_1713 st033146 12.748 µM 1.06471898405081 0.118526099787 no 392 0.143501558297953 754 674619 SGTC_2891 9063876 19.48 µM 1.06440450524137 0.118593594432989 no 393 0.143572746870567 670 6472478 SGTC_912 3474-0017 2.18 µM 1.06413855404356 0.118650695089587 no 394 0.143632968847311 755 3360550 SGTC_2648 atorvastatin 78.68 µM 1.06091463518086 0.119344427125323 no 395 0.144364348786347 728 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_3025 9087895 49.47 µM 1.05997023325493 0.119548187193241 no 396 0.144579070801293 800 17173641 SGTC_2305 7443522 69.23 µM 1.05850617380421 0.119864551211928 no 397 0.144912368804358 788 5415886 SGTC_1246 0422-0085 105 µM 1.05811341629071 0.119949521271845 no 398 0.145001869291113 779 264295 SGTC_1394 3474-0001 65.7 µM 1.05725308373336 0.120135795934715 no 399 0.145198049476647 644 5017666 YIL048W NEO1 SGTC_3064 1327-0027 10 µM 1.05682406157522 0.120228761679356 no 400 0.145295945385921 584 16000455 YPR107C YTH1 SGTC_2251 lansoprazole 556 µM 1.05545389249888 0.120526005988848 no 401 0.145608893100656 592 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1556 plumbagin 1.48 µM 1.05355063322437 0.120939756917022 no 402 0.146044350545402 684 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.05181792312714 0.121317300256519 no 403 0.14644154714751 730 140250 A respiratory chain inhibitor. SGTC_1853 st056710 91.2 µM 1.05100143173497 0.121495494029363 no 404 0.146628966134907 787 269167 SGTC_2640 pentamidine 10.38 µM 1.05034410554325 0.121639084688569 no 405 0.146779966947347 819 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_39 0986-0283 58.349 µM 1.04636003876798 0.12251194256837 no 406 0.147697417677266 838 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2404 5161160 200 µM 1.04439720474538 0.122943586489332 no 407 0.14815082817359 790 2831543 SGTC_2865 9030313 51.95 µM 1.04115636021709 0.123658607345978 no 408 0.148901492833806 709 42562754 SGTC_1033 k072-0102 21.3 µM 1.04071548667763 0.123756100910975 no 409 0.149003806754906 782 5965931 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.03518047203048 0.124984678991414 no 410 0.150292318380987 737 6708514 SGTC_1494 4358-1428 177 µM 1.03466789935628 0.125098881572675 no 411 0.150412016145517 807 1564571 SGTC_201 4262-0159 12.803 µM 1.03408861185581 0.125228036098622 no 412 0.150547369822323 693 1341029 SGTC_2442 5158906 48.48 µM 1.03337958159878 0.125386243984584 no 413 0.150713148988444 776 1893835 SGTC_3302 9125395 16.351 µM 1.03281174089809 0.125513048425 no 414 0.150846004089412 751 17599668 SGTC_2800 7887935 81.82 µM 1.02940004856598 0.126276797147464 no 415 0.151645863156977 734 2961002 SGTC_2918 7977171 22.06 µM 1.02760793505515 0.126679278402465 no 416 0.152067145045507 763 2236483 SGTC_2916 7875993 68.79 µM 1.0258695072081 0.127070555467348 no 417 0.152476548749468 782 1299250 SGTC_2479 5617353 43.85 µM 1.02483105360149 0.127304686508039 no 418 0.152721455576208 785 2731746 SGTC_223 busulfan 5 mM 1.02353973849524 0.127596246372192 no 419 0.153026360513717 694 2478 A DNA alkylator. SGTC_1928 4'-methoxychalcone 40.3 µM 1.02335075600367 0.127638954736583 no 420 0.153071016829729 815 641818 SGTC_1826 st055655 41.6 µM 1.02252768963043 0.127825076312323 no 421 0.153265607064347 791 676168 SGTC_898 1000-0849 28.3 µM 1.02243748544227 0.12784548582038 no 422 0.153286943196991 805 6751807 SGTC_387 norethindrone acetate 66.7 µM 1.01859169642281 0.12871773717441 no 423 0.154198424010644 739 541197 SGTC_1516 st013856 110 µM 1.0182320430831 0.128799519640266 no 424 0.154283847466433 747 5281404 A mutagen and neurotoxin. SGTC_222 nsc-310342 10.666 µM 1.01819796528693 0.128807270544076 no 425 0.154291943114186 699 432556 SGTC_1976 st070609 63.5 µM 1.01543004701858 0.129437906885748 no 426 0.154950438098975 807 682556 SGTC_2361 9034121 116 µM 1.01526275459867 0.129476090860358 no 427 0.154990296795328 760 6496917 SGTC_2253 7938677 135.83 µM 1.01499416419786 0.129537412106669 no 428 0.155054304670025 785 2301972 SGTC_2344 7990960 76.95 µM 1.01352157064474 0.129873974040077 no 429 0.155405549115036 745 140813 SGTC_2529 gangaleoidin 93.61 µM 1.01351893630202 0.129874576662316 no 430 0.155406177931111 802 4565183 SGTC_2436 5633522 8.09 µM 1.01092109305537 0.130469791927515 no 431 0.156027098803342 803 5724242 SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.00993411378947 0.130696421410473 no 432 0.156263428660457 841 165506 SGTC_506 n9-isopropylolomoucine 153 µM 1.00979393562929 0.130728631078141 no 433 0.156297013104301 812 6610355 SGTC_1412 3909-8563 178 µM 1.00857149233555 0.131009752583045 no 434 0.156590092464898 875 23767530 SGTC_3230 9131665 49.47 µM 1.00241405178617 0.132432108976745 no 435 0.158071829130911 688 15943720 SGTC_3174 9107204 49.47 µM 1.00232827833882 0.132451997333778 no 436 0.158092534581472 773 3938802 SGTC_930 2810-3379 265 µM 0.998635982339485 0.133310084629871 no 437 0.15898553137157 874 1015764 SGTC_3107 9121808 49.47 µM 0.995799822991318 0.133971798146881 no 438 0.15967370816076 764 662681 SGTC_2563 tomatine 8.54 µM 0.992508785148792 0.134742465607616 no 439 0.160474698045784 848 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.990993187928967 0.135098396441304 no 440 0.160844453295809 772 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_831 k061-1017 217 µM 0.98966328017073 0.135411249626465 no 441 0.161169364304006 940 1240153 SGTC_2776 terbinafine 19.92 µM 0.989192349598557 0.135522152294226 no 442 0.161284520386147 780 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_846 0335-0850 148 µM 0.987245709014418 0.135981240263725 no 443 0.161761099350439 806 6819598 SGTC_209 4077-0173 175.592 µM 0.986089700297731 0.136254372069501 no 444 0.162044548708266 705 15993494 SGTC_1807 st050092 58.9 µM 0.983850412246276 0.136784519106031 no 445 0.162594534098599 780 5008496 SGTC_1870 st057514 26.5 µM 0.981432673376186 0.137358495208768 no 446 0.163189710175155 795 5393161 SGTC_186 3455-3465 67.277 µM 0.980191331889092 0.137653830298892 no 447 0.163495841228863 757 755278 SGTC_1606 st000094 49.2 µM 0.979676839897597 0.137776363155208 no 448 0.163622830937594 880 1242210 SGTC_656 4090-1979 187 µM 0.976200761932144 0.13860618553623 no 449 0.164482492871143 884 22330961 SGTC_2300 7976697 71.57 µM 0.975536816751842 0.138765071519387 no 450 0.164647024217135 731 2236109 SGTC_848 0368-0089 85.6 µM 0.973879736619686 0.139162161518499 no 451 0.165058128011974 853 762535 SGTC_1009 4106-0057 9.87 µM 0.9702373830154 0.140037703229569 no 452 0.165964090463309 893 2928005 SGTC_2495 cafestol 54.53 µM 0.969363588602325 0.140248299641085 no 453 0.166181906338444 770 16667697 An anti-infammatory. SGTC_3147 9097027 49.47 µM 0.966394441409632 0.140965511477615 no 454 0.166923422235048 892 25236841 SGTC_1059 3448-6867 171 µM 0.965358555459361 0.14121631908813 no 455 0.167182626155309 859 3934407 SGTC_3093 9117344 49.47 µM 0.964924959213052 0.141321390718986 no 456 0.167291199502269 795 24824913 SGTC_1265 0819-1001 68.8 µM 0.964760143505522 0.141361343741454 no 457 0.167332481595082 798 3106768 SGTC_3108 9121785 49.47 µM 0.963748544782284 0.141606733364589 no 458 0.16758600483534 830 17140271 SGTC_2326 6164455 177.58 µM 0.961607993285762 0.142126930810456 no 459 0.168123277387378 779 2888790 SGTC_807 1315-0151 48 µM 0.959126843208306 0.142731517165584 no 460 0.168747424520244 923 4011080 SGTC_916 4466-0038 42 nM 0.958070957910463 0.142989333291481 no 461 0.169013489450008 955 5722064 YGL116W CDC20 SGTC_985 1493-0307 8.71 µM 0.955916717314617 0.143516310874052 no 462 0.169557156161619 816 3278274 SGTC_1572 epiandrosterone 68.9 µM 0.954518477446637 0.143859053783506 no 463 0.169910630403936 888 441302 A steroid. SGTC_35 0133-0054 64.071 µM 0.954142588797759 0.143951287415418 no 464 0.170005735355582 797 99677 SGTC_1289 0976-0073 69.1 µM 0.953092375819265 0.14420919465708 no 465 0.1702716343644 886 3391136 SGTC_863 0466-0191 129 µM 0.952560030309053 0.144340044908868 no 466 0.1704065183864 894 765160 YPR165W RHO1 SGTC_101 0490-5701 117.494 µM 0.951629348176591 0.144568998286555 no 467 0.17064249603892 800 4661669 SGTC_3164 9100705 49.47 µM 0.951032361400388 0.144715989346725 no 468 0.170793974164737 832 17174235 SGTC_586 0957-0265 8.15 µM 0.950635723687378 0.144813705770175 no 469 0.170894663720732 776 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2471 5466956 24.79 µM 0.948846875220081 0.145254961866728 no 470 0.171349248560906 836 724419 SGTC_2970 9090938 41.86 µM 0.948795490374647 0.145267650342831 no 471 0.171362317965108 915 17217104 SGTC_1293 1000-1278 195 µM 0.948173599149136 0.145421273266892 no 472 0.171520542510613 878 678847 SGTC_2083 5306046 65.942 µM 0.947706807637561 0.145536654390348 no 473 0.171639367159453 842 539837 SGTC_2721 ifenprodil 61.44 µM 0.947191701437537 0.145664049328643 no 474 0.171770551631178 844 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2695 st077686 51.995 µM 0.946651583780267 0.145797710544222 no 475 0.171908174645474 808 2876092 SGTC_1546 5-methoxyflavanone 78.7 µM 0.945864556673245 0.145992621198048 no 476 0.172108836662955 899 147795 SGTC_3176 9106582 49.47 µM 0.93962915863018 0.147543031073763 no 477 0.173703907081783 740 17018027 SGTC_3265 9137266 49.47 µM 0.939294523195572 0.147626547715453 no 478 0.173789774879301 854 17224265 SGTC_2395 5646831 180.19 µM 0.93899223820759 0.147702017710115 no 479 0.173867364724889 848 6808628 SGTC_1291 0993-0025 5.79 µM 0.938301661003567 0.147874527624247 no 480 0.174044703199407 896 4353356 SGTC_2537 larixol 68.93 µM 0.937708121151153 0.148022904834208 no 481 0.174197214582595 915 6708759 SGTC_1090 efavirenz 20.7 µM 0.935782586986509 0.148504949026806 no 482 0.174692569353641 871 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2731 amoxapine 43.43 µM 0.934061498794514 0.148936699060342 no 483 0.175136085353584 823 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_875 0709-0210 25.7 µM 0.933329129568941 0.149120674404001 no 484 0.175325029752733 939 6251364 SGTC_3120 9124077 49.47 µM 0.931789460562523 0.149507942858191 no 485 0.17572267122503 897 18774327 YGL155W CDC43 SGTC_570 0987-0065 62.6 µM 0.93165408976252 0.149542024354466 no 486 0.175757659969159 768 3104428 SGTC_1937 st074714 47.2 µM 0.926823598757969 0.150761561776233 no 487 0.177009065117932 860 17250970 SGTC_1813 st051246 8.6015 µM 0.926799617712442 0.150767632659965 no 488 0.177015291748438 866 5291959 SGTC_2478 5763493 32.33 µM 0.926259604101619 0.150904382052335 no 489 0.177155541847342 891 1365576 YLR208W SEC13 SGTC_169 k015-0017 16.025 µM 0.925363477019954 0.151131493334868 no 490 0.177388435097052 816 1840002 SGTC_376 3970-0862 59.1 µM 0.922379204837221 0.151889455665246 no 491 0.178165406430944 904 3135186 SGTC_1253 0550-0034 176 µM 0.920624655104195 0.152336263013806 no 492 0.178623212692347 817 5969915 SGTC_2221 6807166 181.081 µM 0.920281516631014 0.152423747322609 no 493 0.178712832700649 826 674925 SGTC_806 3966-4455 5.86 µM 0.919821623689596 0.152541050858016 no 494 0.178832990724982 797 714982 SGTC_3175 9106517 49.47 µM 0.918132452768349 0.152972416631002 no 495 0.179274763275621 864 41468073 SGTC_2497 7-hydroxyflavone 100 µM 0.911860752614691 0.154581098336575 no 496 0.18092101213845 827 5281894 SGTC_3159 9100096 49.47 µM 0.907813722963403 0.155625069345015 no 497 0.181988323395654 904 25236875 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.90733673007384 0.155748419979052 no 498 0.182114378185619 745 4000243 SGTC_1356 1502-0781 85.8 µM 0.906383145194085 0.155995210799533 no 499 0.182366545402637 878 567702 SGTC_979 1426-2828 121 µM 0.905649629658244 0.156185222256606 no 500 0.182560665571305 954 747872 SGTC_3145 9085516 49.47 µM 0.905271006732661 0.156283361206264 no 501 0.182660916172419 858 25236195 SGTC_1979 st071809 45.3 µM 0.904156954833254 0.15657235867827 no 502 0.182956090691533 920 4976333 SGTC_2545 solidagenone 89.61 µM 0.903549078898266 0.156730196735918 no 503 0.183117276394163 690 6708572 An anti ulcer agent SGTC_3021 9087658 49.47 µM 0.90166826983801 0.157219221357762 no 504 0.183616556635708 909 25237042 SGTC_1339 1486-1321 22.7 µM 0.901172015377372 0.157348418383608 no 505 0.183748433830725 904 3469382 SGTC_41 0478-0632 82.643 µM 0.898514890937396 0.158041372567625 no 506 0.184455555023921 989 3750424 SGTC_1024 4507-0395 26 µM 0.89521539588344 0.158904635425988 no 507 0.185335978097274 870 4201836 SGTC_2681 menadione 3.18 µM 0.892284088073178 0.159674155044849 no 508 0.186120340410773 909 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2281 7943571 200 µM 0.891968926848423 0.159757035325677 no 509 0.186204793898846 1013 1244024 SGTC_1452 4194-0072 190 µM 0.891514691310903 0.159876538516434 no 510 0.186326556786115 992 1343545 SGTC_3055 9094636 49.47 µM 0.891188562021385 0.159962374748168 no 511 0.186414009785666 885 25236176 SGTC_2304 7443016 91.4 µM 0.891148027000158 0.159973045547236 no 512 0.186424881205633 839 939854 SGTC_2871 9038510 12.99 µM 0.89078339965946 0.16006905421505 no 513 0.18652269125853 961 4945164 SGTC_187 1488-2104 32.728 µM 0.889597151932568 0.160381661297914 no 514 0.1868411180278 961 2852859 SGTC_2719 novobiocin 32.65 µM 0.889027535398718 0.160531911727082 no 515 0.186994140781674 879 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2371 9071574 200 µM 0.888408770383892 0.160695230444124 no 516 0.18716045469817 897 45596039 SGTC_1350 1495-0454 146 µM 0.886833728663476 0.16111144119233 no 517 0.187584212785488 969 1069057 SGTC_2756 carbadox 75.1 µM 0.885323285919303 0.161511241558421 no 518 0.187991147180455 887 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_726 3448-4391 34.2 µM 0.8847070828515 0.161674530485547 no 519 0.188157317301608 967 1356692 SGTC_1920 st075728 45.7 µM 0.883412967536661 0.16201781094042 no 520 0.188506593487767 912 3400306 SGTC_535 2293-4129 48.2 µM 0.882495570996545 0.16226144933096 no 521 0.188754436901128 1001 396118 YIL048W NEO1 SGTC_2905 7799065 20.05 µM 0.882242844609044 0.16232860924652 no 522 0.188822748610212 903 1296806 SGTC_26 0302-0163 425.158 µM 0.881892730627269 0.162421678990383 no 523 0.188917409264683 949 3100915 SGTC_1282 0886-0010 32.4 µM 0.88145342287248 0.162538507962466 no 524 0.189036226676618 1020 2836211 YNL267W PIK1 SGTC_769 0302-0231 76 µM 0.880837603924645 0.16270237013125 no 525 0.189202861671311 993 571869 YER009W NTF2 SGTC_1785 bathophenanthroline 24 µM 0.879781599776325 0.162983610424817 no 526 0.189488817213365 894 72812 An iron chelator. SGTC_1902 st060212 70.5 µM 0.877958025926172 0.163470017354497 no 527 0.18998324883803 987 688944 SGTC_2380 9035439 200 µM 0.877201093242053 0.163672192717288 no 528 0.190188711196058 998 6462575 SGTC_3203 9113543 49.47 µM 0.876817471034575 0.163774719478402 no 529 0.1902928939971 897 17018012 SGTC_2754 granisetron 64.02 µM 0.876410999632933 0.163883398383419 no 530 0.190403320346808 931 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_3242 9133940 49.47 µM 0.875883953145177 0.164024385307644 no 531 0.190546561990567 966 17248444 SGTC_901 1112-0062 60.1 µM 0.875445334705801 0.164141777368505 no 532 0.190665820925993 909 1908457 SGTC_845 0330-0138 4.51 µM 0.874708560655489 0.164339090564471 no 533 0.19086625049218 965 9039800 SGTC_752 1896-0090 130 µM 0.874270437884164 0.164456495759797 no 534 0.190985497220471 953 772567 SGTC_1225 1216-0074 20.6 µM 0.873298332464509 0.164717188127807 no 535 0.191250244613259 941 4241466 SGTC_1276 0871-0068 94.2 µM 0.873263327433807 0.164726580520947 no 536 0.191259782229157 929 3414906 SGTC_2676 harmalol 100 µM 0.87230353444535 0.164984243052339 no 537 0.191521404990286 958 5459187 A monoamine oxidase inhibitor SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.871263378520596 0.165263774020688 no 538 0.191805180698698 1135 16725076 SGTC_1185 1319-0113 81.3 µM 0.870763800316403 0.16539813930087 no 539 0.191941567268486 909 4672763 SGTC_3264 9137442 49.47 µM 0.870223375832403 0.16554357005188 no 540 0.192089171832419 921 17015726 SGTC_3092 9117248 49.47 µM 0.869704018552407 0.165683409429693 no 541 0.192231087798454 1009 17141857 SGTC_1901 st060216 58.6 µM 0.868878630245625 0.165905806198602 no 542 0.19245675959295 1000 688792 SGTC_2621 lithochol-11-enic acid 100 µM 0.867234079738334 0.166349497049919 no 543 0.192906883502453 976 6708711 SGTC_2349 9023730 187.07 µM 0.86682486270878 0.166460020539624 no 544 0.193018988629229 944 4126287 SGTC_984 1492-0255 2.91 µM 0.865387591747962 0.166848581813532 no 545 0.193413044567781 912 1585198 SGTC_841 0251-0215 91.2 µM 0.863928948214974 0.167243518814343 no 546 0.193813461637556 985 3888614 SGTC_932 2857-0803 154 µM 0.862486978309928 0.167634533111803 no 547 0.194209797860214 1008 674898 SGTC_2645 abamectin 100 µM 0.861832774338992 0.167812125486681 no 548 0.194389773376507 934 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2429 5902844 64.44 µM 0.860089249270423 0.168286019945911 no 549 0.194869923468373 995 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2791 5663188 71.43 µM 0.858214777243644 0.168796465358329 no 550 0.195386938862816 936 54690634 SGTC_1384 3089-0840 101 µM 0.856370927663167 0.169299541423869 no 551 0.195896320105856 922 1069836 SGTC_829 1635-0120 117 µM 0.854537695861206 0.169800673675812 no 552 0.196403566104201 1005 285054 SGTC_189 3970-0742 2.116 µM 0.853090171245557 0.17019704038423 no 553 0.19680465076993 978 2891807 SGTC_1975 st070967 30.8 µM 0.852152790544569 0.170454033543491 no 554 0.197064647553337 1043 261391 SGTC_1464 k208-0027 110 µM 0.851276713236167 0.17069444425323 no 555 0.197307828739449 983 X1464 SGTC_2821 7996764 71.43 µM 0.85073813885772 0.170842346017738 no 556 0.197457416051951 1022 2987135 SGTC_1206 3978-0017 132 µM 0.849711268262147 0.171124569461545 no 557 0.197742816030812 930 3873677 SGTC_626 0214-0009 33 µM 0.849643831072739 0.171143114216753 no 558 0.197761567688057 1004 3437874 SGTC_2732 terfenadine 20 µM 0.848578516752703 0.17143623870291 no 559 0.198057932666948 965 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2956 9076196 2.52 µM 0.848154867434441 0.171552896227355 no 560 0.198175864229285 982 16423868 SGTC_523 1934-0222 13.7 µM 0.847238736953536 0.171805338445979 no 561 0.198431033038654 943 1361595 SGTC_3052 9092717 49.47 µM 0.845224356372202 0.172361240270138 no 562 0.198992792934398 944 25237534 SGTC_1568 digitonin 820 nM 0.84471879425234 0.172500938474501 no 563 0.199133931748192 1015 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_225 nsc-122657 1.016 µM 0.844527991196253 0.172553680421163 no 564 0.199187214299218 861 275685 SGTC_2043 5101342 149 µM 0.84448227741458 0.172566318191247 no 565 0.19919998133892 944 678451 SGTC_156 3474-0145 5.642 µM 0.843818871360741 0.172749786055687 no 566 0.199385314229635 972 2265471 SGTC_1186 1319-0216 26 µM 0.842242283852261 0.173186296904591 no 567 0.19982617501447 1034 4565136 SGTC_3015 9080845 49.47 µM 0.842097363648844 0.173226456280944 no 568 0.199866728418771 1046 5296973 SGTC_129 0088-0017 176.636 µM 0.841555712599108 0.173376607714161 no 569 0.200018343883412 950 182446 SGTC_562 3772-2733 112 µM 0.840139067789905 0.173769708313557 no 570 0.200415208743459 1042 2876874 YIL048W NEO1 SGTC_2051 5263410 176 µM 0.836884782449249 0.174674875471551 no 571 0.201328667462246 1035 227584 SGTC_3034 9090421 49.47 µM 0.833560105301239 0.175602707387278 no 572 0.202264457293659 950 17173761 SGTC_2365 9042475 200 µM 0.833092121571189 0.175733559908667 no 573 0.202396388258058 993 6464479 SGTC_1211 1056-0033 32.3 µM 0.832975214370626 0.175766257869409 no 574 0.202429354015951 1011 6741922 SGTC_2160 5660466 132.927 µM 0.831217752987143 0.176258269423094 no 575 0.202925313778312 950 2859134 SGTC_2912 7964298 10.93 µM 0.829398639462133 0.176768457878961 no 576 0.20343943555697 1009 2975850 SGTC_2079 5212404 121 µM 0.828047531727169 0.177147993022059 no 577 0.203821790958302 1024 758462 SGTC_891 0929-0073 133 µM 0.826475620844113 0.17759020050986 no 578 0.204267170961579 1019 5603632 SGTC_1390 3413-2614 145 µM 0.825170674350082 0.177957834729935 no 579 0.20463735001874 1060 3421432 SGTC_3334 9142812 21.919 µM 0.824524853148143 0.178139955202804 no 580 0.204820700080772 974 45283678 SGTC_2317 5986382 200 µM 0.82293102601938 0.178589914262253 no 581 0.205273608969129 1031 877883 SGTC_450 aminopyrene 156 nM 0.816465883717415 0.180422443059538 no 582 0.20711686417108 1004 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_856 0433-0016 11.3 µM 0.816360488522772 0.180452414461944 no 583 0.207146993927381 1013 3911780 SGTC_2945 9067681 61.76 µM 0.815856396133531 0.180595807221735 no 584 0.207291136735573 1036 16456930 SGTC_2551 apiole 73.87 µM 0.815727060468759 0.180632609211611 no 585 0.207328129209033 901 10659 A possible DNA adduct former. SGTC_1634 st006576 41 µM 0.814555105017047 0.180966299191567 no 586 0.207663508771971 1014 3915356 SGTC_1222 0366-0074 1.18 µM 0.813255883556848 0.181336676698553 no 587 0.208035682536262 1072 286520 SGTC_2188 6126565 140.678 µM 0.811293609869471 0.181896973903788 no 588 0.208598539426607 984 874518 SGTC_603 3794-0023 45.9 µM 0.810912713038124 0.182005858513222 no 589 0.208707899498527 1025 3802260 SGTC_595 3909-8003 73.7 µM 0.810800989025759 0.182037804090784 no 590 0.208739983217523 1031 699517 SGTC_2379 9035213 200 µM 0.810418165301 0.18214729259585 no 591 0.208849940522731 1062 646551 SGTC_894 0960-0238 55.9 µM 0.809902407227378 0.182294865715544 no 592 0.208998134107495 1032 6741907 YDL195W SEC31 SGTC_693 4161-2696 114 µM 0.80970017808075 0.18235274963707 no 593 0.209056257827552 984 805759 SGTC_2350 9023895 38.85 µM 0.804945768964736 0.183716908414395 no 594 0.210425487596755 1012 2997209 SGTC_737 1950-0117 57.9 µM 0.804080047288211 0.183965988126509 no 595 0.210675373496665 1038 5393513 SGTC_1687 st020778 55.3625 µM 0.801579097562179 0.184686725258074 no 596 0.211398236370992 1097 4259299 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.80082018077976 0.184905780702816 no 597 0.211617877099141 1016 5282362 SGTC_1383 3049-0032 20.7 µM 0.800726377042472 0.184932867631743 no 598 0.211645034435969 1065 712864 SGTC_705 1124-0212 310 µM 0.800251233094278 0.185070108890887 no 599 0.211782625792394 1040 9554485 SGTC_384 k007-0144 5.16 µM 0.798754416939999 0.185502864873035 no 600 0.212216413220428 1044 6824886 SGTC_2419 paclitaxel 166.5 µM 0.797111883384126 0.185978472422586 no 601 0.212693027702202 1048 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_215 1287-0124 461.5 µM 0.795342118721926 0.186491765999785 no 602 0.213207259718891 1041 5560863 SGTC_3066 9117245 49.47 µM 0.794721848259568 0.186671873549375 no 603 0.213387660176821 1080 17176980 SGTC_155 k072-0202 43.6 µM 0.793599648980366 0.186997999403584 no 604 0.21371426844009 1024 5857737 SGTC_2143 5623677 140.463 µM 0.792852773103248 0.187215246590085 no 605 0.213931802743896 1038 5375313 SGTC_1247 0448-0043 5.84 µM 0.791805877553483 0.187520024446538 no 606 0.214236937351104 1065 3089013 YGL099W LSG1 SGTC_2294 7971431 200 µM 0.791495663699814 0.187610394426253 no 607 0.214327402791543 967 5741572 SGTC_48 0382-0018 55 µM 0.789386561618248 0.188225520849658 no 608 0.214943053889161 1094 762596 SGTC_2284 7945075 39.21 µM 0.788994567199739 0.188339984275554 no 609 0.21505759092091 1124 1245402 SGTC_1617 st002906 78 µM 0.78836020896213 0.188525309536248 no 610 0.215243019406935 1052 5150859 SGTC_1686 st019653 115.5 µM 0.787820402822178 0.188683100298326 no 611 0.215400882533826 1071 97252 SGTC_2894 9048625 32.47 µM 0.78765069621289 0.188732724061715 no 612 0.215450526106863 1079 4092861 SGTC_3341 9147222 25.867 µM 0.787293805736362 0.188837108341527 no 613 0.215554947454938 1009 1939759 SGTC_1911 st060208 74.3 µM 0.78608020876222 0.189192330524242 no 614 0.215910249107596 1074 688783 SGTC_2892 9047358 58.44 µM 0.784207264802404 0.189741351695928 no 615 0.216459251527321 1015 6466771 SGTC_2297 7971671 152.32 µM 0.779442221611142 0.191142553250871 no 616 0.217859630277401 1054 909016 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.779318221299435 0.1911791010969 no 617 0.217896141832229 1068 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1264 0783-0040 158 µM 0.776779181799106 0.191928399220981 no 618 0.218644530617103 1006 2855798 SGTC_3116 9124943 49.47 µM 0.776047055359173 0.192144791129666 no 619 0.21886060139377 1029 41905195 YPL160W CDC60 SGTC_2013 4024628 200 µM 0.775671830635355 0.192255752746378 no 620 0.218971388194122 1049 5230760 SGTC_2830 7992007 71.43 µM 0.775321907562174 0.192359267459522 no 621 0.219074733628329 1003 1952075 SGTC_1991 st073000 8.92 µM 0.774297018898683 0.192662647446001 no 622 0.219377583091803 1090 4301969 YIL048W NEO1 SGTC_649 1123-0311 367 µM 0.772664111560679 0.193146612293282 no 623 0.219860595661589 1080 693629 YIL048W NEO1 SGTC_3239 9133757 49.47 µM 0.772327076670676 0.193246595793149 no 624 0.219960366226554 1092 17036923 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.770511238024129 0.193785819011607 no 625 0.220498345673752 1078 97141 SGTC_682 0kpi-0099 17 µM 0.770381192694842 0.193824471848294 no 626 0.220536903182389 1102 1714895 YML126C ERG13 SGTC_2328 6201408 200 µM 0.770048998310015 0.19392322994774 no 627 0.220635413975047 1013 2890418 SGTC_2917 7979103 53.79 µM 0.767294650232405 0.194743251029043 no 628 0.22145317423417 1099 2980565 SGTC_1122 capsaicin 818.572 nM 0.766680733352673 0.194926312667363 no 629 0.2216356807626 1086 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3253 9135987 49.47 µM 0.766678801864304 0.194926888775918 no 630 0.221636255095213 1026 4182430 SGTC_2653 dihydrofissinolide 100 µM 0.766499450385205 0.194980388780063 no 631 0.2216895893857 1109 6857746 SGTC_2819 7996655 46.38 µM 0.765972200289602 0.195137717583022 no 632 0.22184642179722 973 6456960 SGTC_669 0108-0021 26.2 µM 0.765652042959028 0.195233288575956 no 633 0.221941684645523 1157 17201 SGTC_488 nitrendipine 139 µM 0.765541413892743 0.195266319355858 no 634 0.221974607765681 1103 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.764528470773254 0.195568914016332 no 635 0.22227618844386 1079 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1951 sophoraflavanone G 9.2 µM 0.76424073876671 0.195654919576444 no 636 0.222361896692183 1121 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1619 st003326 88.7 µM 0.764182072330981 0.195672458294133 no 637 0.222379374285881 1080 2849032 SGTC_3293 9120939 62.045 µM 0.763152855623097 0.195980304639771 no 638 0.222686120507103 1062 934087 SGTC_2761 levamisole 97.89 µM 0.763152377206084 0.195980447806132 no 639 0.222686263149856 1076 26879 An alkaline phosphatase inhibitor. SGTC_399 oxolinic acid 75 µM 0.762580120475025 0.196151741141576 no 640 0.222856922032444 1056 4628 A DNA gyrase inhibitor. SGTC_1261 0712-0010 12.7 µM 0.762421433308795 0.196199256970059 no 641 0.222904259045433 1108 2840123 SGTC_484 loperamide 105 µM 0.761747743855833 0.196401058055878 no 642 0.223105287055364 1043 3955 An opioid-receptor agonist. SGTC_162 k030-0015 37.8 µM 0.761213177640217 0.196561274792193 no 643 0.223264874309707 1145 1809920 YMR134W ERG29 SGTC_1658 st012944 20 µM 0.760553749709191 0.19675902333204 no 644 0.223461826758812 1051 24207260 SGTC_109 0132-0036 33.701 µM 0.759674849681445 0.197022774154118 no 645 0.223724482901912 986 67274 A color developer. SGTC_1876 myriocin 605 nM 0.759264578386689 0.197145966491726 no 646 0.223847151080634 1106 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2872 9044037 25.97 µM 0.758321813033985 0.197429227603385 no 647 0.224129175966609 1112 6465195 SGTC_2117 5521686 200 µM 0.756597599459068 0.197947917092514 no 648 0.224645489982139 1093 803312 SGTC_1146 3579-1023 7 µM 0.755785372729208 0.198192541511185 no 649 0.224888944027271 1137 X1146 SGTC_2708 st078559 56 µM 0.754948045756174 0.19844491650853 no 650 0.225140078028102 1027 17250902 SGTC_2002 4023503 131 µM 0.753651848559183 0.198835979723358 no 651 0.225529151132494 1183 4736863 YCR052W RSC6 SGTC_265 mycophenolic acid 32.932 µM 0.753612325582076 0.198847911115263 no 652 0.225541020524748 1176 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_618 k072-0232 33.2 µM 0.753175715941496 0.198979745709762 no 653 0.225672165017441 1085 5872756 YGL099W LSG1 SGTC_2929 9013348 24.6 µM 0.753008203367147 0.199030340229588 no 654 0.225722492240049 1084 2995952 SGTC_1981 st071826 47 µM 0.752679805059765 0.199129550228314 no 655 0.225821174149454 1068 11838600 SGTC_2139 5578692 56.4705 µM 0.752571801134969 0.199162185009063 no 656 0.225853634073885 1075 650991 YMR113W FOL3 SGTC_567 1080-0542 68.4 µM 0.749661710484549 0.200042718875116 no 657 0.226729236935315 1068 5950415 SGTC_2603 homopterocarpin 100 µM 0.749272684911199 0.200160607141818 no 658 0.22684643390332 1110 101795 A weak amylase inhibitor. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.748728074275391 0.200325713214274 no 659 0.227010559470218 1157 1377 SGTC_2904 7225135 42.03 µM 0.748555212344493 0.200378135746533 no 660 0.227062667679272 1162 4446116 SGTC_2077 5212015 200 µM 0.748110324833682 0.200513091314247 no 661 0.227196807401836 1059 780900 SGTC_1594 piperine 70.1 µM 0.746765090042205 0.200921497028095 no 662 0.227602685844806 1092 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_722 3534-0461 190 µM 0.746167549736953 0.201103066872551 no 663 0.227783103995264 1128 658262 SGTC_3306 9127676 59.7925 µM 0.746115959616319 0.201118747767854 no 664 0.227798684616309 1122 41905287 SGTC_1727 st034309 9.9045 µM 0.74530511842736 0.201365300495277 no 665 0.228043643791383 1152 870305 SGTC_2762 leflunomide 42.06 µM 0.744208561177373 0.201699019009971 no 666 0.228375154743564 1107 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_181 1447-1644 8.07 µM 0.743197106969565 0.202007131358924 no 667 0.22868117732019 1103 534600 SGTC_3104 9120930 49.47 µM 0.741534513876919 0.202514207351762 no 668 0.229184706509551 1080 17014836 SGTC_3134 9127454 49.47 µM 0.739283353818171 0.203202002384479 no 669 0.229867477579801 1187 24262820 SGTC_1216 1165-0504 9.65 µM 0.738368104488255 0.203482035947968 no 670 0.230145395617495 1123 6304004 SGTC_2104 5389443 200 µM 0.737620391276496 0.203710980212948 no 671 0.230372580284762 1145 2244536 SGTC_1181 1222-0449 220 µM 0.73754659656667 0.20373358393181 no 672 0.230395008814734 1158 658318 SGTC_1070 indatraline 8.81 µM 0.737536668193266 0.203736625160414 no 673 0.2303980264524 1121 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1496 4469-0713 57.4 µM 0.735112686265085 0.204479941467818 no 674 0.231135434376213 1118 746691 SGTC_3132 9126706 49.47 µM 0.734878413369464 0.204551866902828 no 675 0.23120677307164 1137 850858 SGTC_2126 5251174 33.877 µM 0.73465915320482 0.204619196831817 no 676 0.231273551351414 1183 790722 SGTC_3285 9112818 20.8695 µM 0.734331574615164 0.204719813506668 no 677 0.231373339331858 1193 17017947 YPR165W RHO1 SGTC_1859 st055998 20 µM 0.73310870858024 0.205095680118634 no 678 0.231746064527251 1155 676301 SGTC_219 mitoxanthrone 164.414 µM 0.729371233731936 0.20624698979229 no 679 0.232887304603545 1110 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3221 9128209 49.47 µM 0.726978591962397 0.206986037651615 no 680 0.23361953512198 1145 16460723 SGTC_385 1494-0393 12.4 µM 0.724392236285334 0.20778668044843 no 681 0.234412482422875 1138 3090647 SGTC_865 0488-0499 301 µM 0.724315518672202 0.207810457365443 no 682 0.234436025893247 1183 9634651 SGTC_102 gallobenzophenone 83.616 µM 0.724236330832665 0.207835001559442 no 683 0.234460328810749 1160 70837 SGTC_1317 1273-0028 910 nM 0.723725329900877 0.207993426966643 no 684 0.234617189605423 1139 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_482 fipronil 114 µM 0.723638599086195 0.208020323160493 no 685 0.234643818926684 1180 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2485 5633444 17.78 µM 0.723423979503801 0.208086887914677 no 686 0.2347097216509 1130 5724239 SGTC_2441 5730946 39.09 µM 0.720958968954478 0.208852317572371 no 687 0.235467379918021 1161 1774275 SGTC_161 4065-0411 162.148 µM 0.719726231199338 0.209235726004784 no 688 0.235846786155476 1141 1906281 YLR208W SEC13 SGTC_1531 st059297 52.4 µM 0.719572314199106 0.209283626640372 no 689 0.235894181662044 1167 7566702 SGTC_2413 inermin 26.06 µM 0.718438391394592 0.209636714565653 no 690 0.236243511126315 1172 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1301 naphtanilide LB 4.81 µM 0.718370953967365 0.209657724682012 no 691 0.236264295657017 1208 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_309 k408-0051 1.48 µM 0.717630262871398 0.209888568316947 no 692 0.236492646374742 1160 3640463 SGTC_2467 5474540 200 µM 0.717410451412987 0.209957103445634 no 693 0.2365604363215 1163 5413519 SGTC_2256 7954252 200 µM 0.714423818900038 0.210889609696368 no 694 0.237482573868066 1115 2972920 SGTC_1039 k821-0043 94 µM 0.712948030129896 0.211351285354207 no 695 0.23793895830058 1158 15992768 SGTC_2528 xanthyletin 44.79 µM 0.712312664900215 0.21155023082596 no 696 0.23813559157659 1195 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1804 st050076 49.1 µM 0.71184728498917 0.211696020057639 no 697 0.238279674155809 1170 3895976 SGTC_2781 5567276 71.43 µM 0.710994288074731 0.211963390401105 no 698 0.23854388768905 1149 2853274 SGTC_3077 9117319 49.47 µM 0.710274609840294 0.212189125788349 no 699 0.238766930785764 1202 17154678 SGTC_1569 carminic acid 40.6 µM 0.708632112732672 0.212704840038515 no 700 0.239276401496357 1184 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1509 1326-1131 80 µM 0.708547752318737 0.212731347420325 no 701 0.239302584484249 1145 768313 SGTC_786 4544-0069 423 µM 0.708207250878678 0.21283835798104 no 702 0.239408282009202 1165 748821 YLR208W SEC13 SGTC_2336 9001819 198.65 µM 0.707535702508376 0.21304949986813 no 703 0.239616816925243 1217 2989602 SGTC_2280 7785178 200 µM 0.706681492628203 0.213318248957953 no 704 0.239882216651945 1166 2954328 SGTC_3331 9141060 1.957 µM 0.705662409298785 0.213639128482178 no 705 0.240199051558434 1183 4906567 YPR165W RHO1 SGTC_2492 derrusnin 100 µM 0.702719106167602 0.214567465940978 no 706 0.241115409190836 1122 1715307 Part of coumarin class of compounds. SGTC_3310 9130229 44.1445 µM 0.701827145234167 0.214849258690369 no 707 0.241393483955028 1177 7761258 SGTC_939 1165-0479 45.3 µM 0.701130871252012 0.215069378374666 no 708 0.241610673031091 1150 1377347 SGTC_1267 0828-0272 9.49 µM 0.700923605030523 0.215134928688579 no 709 0.241675346168776 1205 745334 SGTC_444 curcumin 90.4 µM 0.698354820478114 0.215948298294868 no 710 0.242477661684508 1145 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1219 1469-0211 33.1 µM 0.697322868343349 0.216275552456575 no 711 0.242800379879658 1165 6822282 SGTC_1706 st031321 9.9705 µM 0.696956852710461 0.216391692806502 no 712 0.24291489828056 1210 6103185 SGTC_2856 9022925 19.48 µM 0.696775358331356 0.216449296137683 no 713 0.242971694795417 1180 4944862 SGTC_2560 caryophyllene 100 µM 0.696426523165257 0.216560035597135 no 714 0.243080878795813 1241 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1834 st055981 52.8 µM 0.695712193851571 0.216786905248545 no 715 0.243304543765138 1215 471719 YDL150W RPC53 SGTC_2457 5731572 11.68 µM 0.695343997681635 0.216903897315437 no 716 0.243419873774394 1231 2865357 SGTC_1492 4158-0558 28.5 µM 0.69485737764294 0.21705857381615 no 717 0.243572342971468 1192 3967268 SGTC_1268 0828-0275 2.46 µM 0.694408276582062 0.217201381115407 no 718 0.243713102367618 1235 745337 SGTC_1208 2323-2347 50.3 µM 0.692158358274719 0.217917637425055 no 719 0.244418943131279 1199 5412760 SGTC_2895 9054447 58.44 µM 0.691973751608915 0.217976466932672 no 720 0.244476906496955 1226 2697450 SGTC_2690 usnic acid 100 µM 0.69177689693286 0.218039209660719 no 721 0.244538723688449 1247 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1540 guanosine 70.6 µM 0.690969394125198 0.218296690822593 no 722 0.244792387438553 1149 6802 Guanosine is a purine nucleoside SGTC_323 4013-0906 34.3 µM 0.690668527243798 0.218392670315666 no 723 0.244886936035813 1220 2910086 SGTC_634 1611-4317 11.2 µM 0.690414703545892 0.218473661470252 no 724 0.244966716409257 1221 2843522 SGTC_108 0509-0257 621.132 µM 0.689418635067492 0.218791658347123 no 725 0.245279929872247 1193 536624 SGTC_3084 9116877 49.47 µM 0.686614465180405 0.219688324264098 no 726 0.246162855297877 1136 27241325 SGTC_607 4491-0986 66.8 µM 0.686135615123898 0.219841652778682 no 727 0.246313796991582 1232 698981 YDR232W HEM1 SGTC_1539 benzyladenosine 56 µM 0.68594756497301 0.219901883515214 no 728 0.246373087167315 1193 92208 A nucleotide analog. SGTC_1646 st011709 75.6 µM 0.685709738155051 0.219978070821221 no 729 0.246448082340135 1196 5757843 SGTC_2403 6032726 181.2 µM 0.684888199381911 0.220241365477987 no 730 0.246707236539252 1206 2881040 SGTC_1236 0330-0013 258 µM 0.68384486947587 0.220576002215807 no 731 0.247036564921687 1202 4617066 SGTC_1241 0364-0022 50.8 µM 0.683736724294327 0.220610705263334 no 732 0.247070714530723 1209 4563895 SGTC_1453 4237-0541 195 µM 0.683590283232007 0.220657702181585 no 733 0.247116961069119 1194 739892 SGTC_2020 4017018 200 µM 0.683052412413574 0.220830368758951 no 734 0.247286862057326 1236 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1006 4099-6547 255 µM 0.682101690186252 0.221135757496258 no 735 0.24758732597313 1220 3146833 SGTC_23 0213-0011 39.996 µM 0.681657352183799 0.221278569511286 no 736 0.247727820307233 1232 627608 SGTC_940 3232-1287 54.8 µM 0.680948260124218 0.221506583768133 no 737 0.247952114838769 1193 1585493 YIL048W NEO1 SGTC_1690 st023502 41.2 µM 0.68024961577579 0.221731369777005 no 738 0.24817321057668 1192 24207482 SGTC_3010 9080089 71.4286 µM 0.680227559790649 0.221738468322993 no 739 0.248180192212159 1224 17027233 SGTC_1079 idarubicin 2.36 µM 0.679946546402588 0.221828921644246 no 740 0.248269153790961 1193 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2490 carminic acid 95.39 µM 0.679132547072667 0.222091052780005 no 741 0.248526940877168 1180 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1182 1222-0449 220 µM 0.678049171556312 0.222440204887248 no 742 0.248870258347066 1201 658318 SGTC_1234 0326-0494 15.5 µM 0.677568168260112 0.222595323744956 no 743 0.249022767297847 1249 1547813 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.677377507626266 0.222656826997312 no 744 0.249083232728312 1163 1241132 A phosphatase inhibitor. SGTC_3061 glucosamine 200 µM 0.677345191057076 0.222667252626888 no 745 0.249093482263373 1174 91431 and experimental redox chemotherapeutic SGTC_1311 1190-0148 100 µM 0.677274267213215 0.222690134302313 no 746 0.249115977282483 1270 1961333 SGTC_2684 capsaicin 100 µM 0.67651447668318 0.222935344400368 no 747 0.249357028934751 1234 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_345 1362-0200 395 µM 0.675596776434684 0.223231722276611 no 748 0.249648344370938 1201 1419823 SGTC_301 4119-0100 24.5 µM 0.672636052876689 0.224189436695763 no 749 0.250589429648603 1238 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2835 9006588 71.43 µM 0.671569763793939 0.224534923163513 no 750 0.250928816303947 1232 2345538 SGTC_797 k781-0471 270 µM 0.671516428712038 0.224552212099641 no 751 0.250945798588462 1230 23738129 SGTC_1714 st033236 13.627 µM 0.671179537423271 0.224661435194775 no 752 0.251053081319963 1275 2916566 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.67103896240647 0.22470701975049 no 753 0.251097854483304 1242 5106787 A p450 inhibitor. SGTC_1701 st028638 40.4 µM 0.670863409133361 0.224763954143936 no 754 0.251153774157216 1221 3490878 SGTC_3311 9131146 2.8755 µM 0.670367148233782 0.224924942765521 no 755 0.251311885712626 1227 4900406 YPR165W RHO1 SGTC_931 2812-0076 566 µM 0.669697921690052 0.225142145461057 no 756 0.251525188414146 1261 3450959 SGTC_644 1498-1197 63.3 µM 0.669657793238753 0.225155173238062 no 757 0.251537981602147 1270 6741615 SGTC_3013 9080133 71.4286 µM 0.668758731623208 0.225447167224809 no 758 0.251824697886037 1308 17050193 SGTC_989 1501-0895 10.3 µM 0.667851464841988 0.225742043242513 no 759 0.252114205656715 1236 2830112 SGTC_2411 st077133 39.94 µM 0.666273943677127 0.226255281622432 no 760 0.252618008543827 1346 1403142 YNL221C POP1 SGTC_3085 9117376 49.47 µM 0.665522673873162 0.22649993492358 no 761 0.252858123074763 1281 16480349 SGTC_1378 2093-0007 380 nM 0.664797657917202 0.226736180140579 no 762 0.253089960435442 1246 3618014 SGTC_798 1287-0182 476 µM 0.662561242543235 0.227465787557721 no 763 0.25380579975476 1276 1649755 SGTC_29 0299-0004 12.984 µM 0.661916460487639 0.227676386368445 no 764 0.254012380978473 1146 16871 A napthoquinone isolated from Swertia calycina. SGTC_1029 k015-0030 64.7 µM 0.660775276062112 0.228049389107956 no 765 0.254378220301658 1283 2208316 SGTC_1740 st038286 13.222 µM 0.660426334928659 0.228163511112487 no 766 0.254490138472608 1271 716786 SGTC_3224 9130643 49.47 µM 0.657569753321992 0.22909896921727 no 767 0.255407317798146 1292 17644395 SGTC_1616 st002734 56.1 µM 0.656943354698075 0.229304386118291 no 768 0.255608669938343 1232 4026101 SGTC_2623 humulene 100 µM 0.655683884727931 0.22971772049375 no 769 0.25601376991731 1204 6187145 An anti-inflammatory. SGTC_352 k048-0007 5.11 µM 0.655182834558577 0.229882271690159 no 770 0.256175022383678 1237 6811911 SGTC_2491 paeonol 100 µM 0.654447530514503 0.230123874242471 no 771 0.256411760390062 1206 11092 Increases levels of cortical cytochrome oxidase. SGTC_2075 5212009 200 µM 0.6543798324296 0.230146125282568 no 772 0.256433562150595 1211 780898 SGTC_3225 9130819 49.47 µM 0.654182120287283 0.230211116297608 no 773 0.256497239684476 1273 4547121 SGTC_1512 0259-0544 12.2 µM 0.653903820047756 0.23030261524902 no 774 0.256586886339759 1255 18476 SGTC_2333 9017922 200 µM 0.653543793914554 0.23042101402925 no 775 0.256702882916155 1295 3163164 SGTC_944 3370-0224 231 µM 0.653404255483004 0.230466912013546 no 776 0.256747848049466 1258 4580514 SGTC_513 4245-1575 41.7 µM 0.652852942575661 0.230648303793816 no 777 0.256925544278502 1241 719745 SGTC_2875 9039966 71.43 µM 0.652186684700677 0.230867620925582 no 778 0.257140374317207 1313 6463691 SGTC_2036 5160441 105 µM 0.651319865424497 0.231153132596925 no 779 0.257420013682175 1290 134534 YIL048W NEO1 SGTC_190 3970-0790 3.722 µM 0.651012279325358 0.231254492199226 no 780 0.2575192801554 1248 2832352 SGTC_1711 st032263 62.8 µM 0.650992596802195 0.231260979073353 no 781 0.257525632922441 1274 3958979 SGTC_2806 7952793 58.44 µM 0.649866606946727 0.231632246515589 no 782 0.257889194942704 1292 2972490 SGTC_1382 3002-2117 298 µM 0.649521332889914 0.23174615864975 no 783 0.258000731098539 1308 1497314 SGTC_1482 3346-2049 8.48 µM 0.647888690748736 0.232285219225927 no 784 0.258528472943047 1276 3826804 SGTC_818 4072-2707 53.5 µM 0.647131786942098 0.232535367806067 no 785 0.258773327128458 1221 882871 SGTC_435 c-PAF 6.7 µM 0.645361420897605 0.233121039246465 no 786 0.259346499023567 1237 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_105 0111-0055 734.78 µM 0.645078084734226 0.233214848311239 no 787 0.259438292501561 1242 5179370 SGTC_2723 salbutamol 83.58 µM 0.644034563605083 0.233560525749733 no 788 0.259776510612976 1265 9884233 β2-adrenoceptor agonist SGTC_732 3970-1727 52.7 µM 0.643945975308585 0.233589884641333 no 789 0.259805233650106 1291 1275699 SGTC_2005 4024620 188 µM 0.643693092258939 0.233673703425838 no 790 0.259887235089171 1278 236743 SGTC_2718 lomofungin 53.02 µM 0.642623841785198 0.234028293685118 no 791 0.260234104448224 1312 5351222 A RNA synthesis inhibitor. SGTC_1631 benzylvanillin 81.9 µM 0.642199413012339 0.234169127492237 no 792 0.260371857047018 1298 75506 SGTC_2857 9024691 58.44 µM 0.641948625764189 0.23425236567989 no 793 0.260453270204913 1300 16478292 SGTC_2149 5554786 194.827 µM 0.641769967296831 0.234311673767616 no 794 0.260511276165118 1300 745063 YPR165W RHO1 SGTC_2323 6148992 148.28 µM 0.641663282151886 0.234347093303091 no 795 0.260545917349674 1234 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_3042 9091578 49.47 µM 0.640817551813923 0.2346279811359 no 796 0.260820613992668 1243 25236497 SGTC_1003 4049-0218 100 µM 0.63948334104205 0.235071483636723 no 797 0.261254273785791 1321 295161 SGTC_270 tamoxifen 5.46 µM 0.638332410444002 0.235454434053675 no 798 0.261628659245313 1375 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1510 1123-0200 71.5 µM 0.638279240563384 0.235472133642826 no 799 0.261645961492453 1381 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1217 1183-1422 255 µM 0.637795492837689 0.2356332009411 no 800 0.261803406960436 1318 2849664 SGTC_2364 9055074 200 µM 0.637377258540491 0.235772504038181 no 801 0.261939568921089 1254 6470630 SGTC_965 1291-5240 308 µM 0.636521469328851 0.236057686900068 no 802 0.262218296058257 1302 2834598 SGTC_1744 st037937 38.9 µM 0.634083376596697 0.236871197031275 no 803 0.263013205406072 1336 1016152 SGTC_2818 7996756 12.99 µM 0.632842495663936 0.237285828709918 no 804 0.263418251397065 1283 2241621 SGTC_886 0866-0150 153 µM 0.632656776662482 0.237347919690057 no 805 0.263478900824898 1317 271463 SGTC_1244 0416-0015 52.5 µM 0.631899499008333 0.237601190811934 no 806 0.263726275378425 1307 96201 SGTC_2469 5655019 90.81 µM 0.631558020346197 0.237715446672469 no 807 0.263837862544641 1381 2788239 SGTC_1309 pyrazolanthrone 13.4 µM 0.630307697092559 0.238134051322585 no 808 0.264246644006949 1329 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1455 4262-0120 131 µM 0.630007844377794 0.238234501172899 no 809 0.264344725967358 1364 1529587 SGTC_3233 9132340 49.47 µM 0.629853477873626 0.238286222584912 no 810 0.26439522654726 1254 17682950 SGTC_1227 3909-8010 46.6 µM 0.628281990841509 0.238813108499251 no 811 0.264909613547907 1306 15982272 SGTC_266 formosanin C 406 nM 0.62648159308274 0.239417525711338 no 812 0.26549955324598 1281 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_49 0717-0965 32.132 µM 0.626434171035779 0.239433457200628 no 813 0.265515101120991 1369 5889349 YGL099W LSG1 SGTC_996 3970-0799 1.8 µM 0.626104490675141 0.239544229684537 no 814 0.265623203464943 1399 6615648 YGL040C HEM2 SGTC_1423 4048-0112 5.59 µM 0.625373123459717 0.239790068657423 no 815 0.26586309877167 1303 X1423 SGTC_1212 0520-0165 585 µM 0.623939283571579 0.240272433306972 no 816 0.266333730120733 1475 5403258 SGTC_2353 9059630 146.67 µM 0.623647112111082 0.240370788851619 no 817 0.266429681664462 1324 4779114 SGTC_775 4577-0580 57.3 µM 0.622457270285944 0.240771559336165 no 818 0.266820616181927 1366 2006902 SGTC_2090 5301565 104.445 µM 0.621465592288071 0.241105860573731 no 819 0.267146663293952 1330 2056344 SGTC_1338 1486-1223 76 µM 0.621313353473218 0.241157203623586 no 820 0.26719673466787 1361 3444526 SGTC_78 0336-0123 156.75 µM 0.620484628805339 0.241436797998793 no 821 0.267469385410464 1249 6765896 SGTC_2584 androsterone 48.74 µM 0.62040476620931 0.241463751267606 no 822 0.2674956676462 1340 2754130 A steroid. SGTC_2713 st079149 53.4 µM 0.619439968369702 0.241789495317752 no 823 0.26781327889883 1335 3103253 SGTC_1448 4255-0083 152 µM 0.619274831842722 0.24184527414553 no 824 0.267867660845689 1399 5399660 SGTC_1178 0988-0033 191 µM 0.6189075753522 0.241969348871225 no 825 0.267988623879393 1322 5392207 SGTC_1134 3477-0009 42.5 µM 0.618200373457107 0.242208368713161 no 826 0.268221631960386 1436 3973534 SGTC_2555 cholic acid 100 µM 0.617249020860282 0.242530108308046 no 827 0.268535243254066 1311 6708657 Influences liver metabolism. SGTC_1961 st076550 68.7 µM 0.617115016920401 0.242575445925441 no 828 0.268579432163761 1307 1579337 SGTC_2493 resveratrol 26.09 µM 0.611848546470404 0.244360882790854 no 829 0.270318983473185 1263 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1881 5652484 16 µM 0.610965321604744 0.244661005307784 no 830 0.270611269263076 1308 2255129 SGTC_1050 3232-1156 69.3 µM 0.610587428161991 0.244789475263035 no 831 0.270736373818543 1303 700529 SGTC_3065 9113888 49.47 µM 0.610156923226652 0.244935875439427 no 832 0.270878930994429 1390 16648368 SGTC_178 4092-0806 87.505 µM 0.608723649504765 0.245423622728066 no 833 0.271353814301456 1326 2169044 SGTC_1558 st069300 45.6 µM 0.607850541763871 0.245720999492767 no 834 0.271643302292428 1307 24208000 SGTC_2977 9011197 71.43 µM 0.606648958312297 0.246130569819742 no 835 0.272041951084255 1378 2704722 SGTC_2847 9005661 71.43 µM 0.604570875523384 0.24683976598715 no 836 0.272732081562525 1253 2991449 SGTC_764 1951-2361 146 µM 0.604330938749783 0.246921720613782 no 837 0.272811820375927 1294 5438930 SGTC_1842 st055362 61.2 µM 0.604261411836329 0.246945471475309 no 838 0.272834928597223 1357 676032 SGTC_2301 7769476 200 µM 0.604085660937168 0.2470055146159 no 839 0.272893346142747 1375 977820 SGTC_1502 4534-4282 27.7 µM 0.603755965986204 0.247118171922465 no 840 0.273002949622697 1330 3278949 SGTC_1501 4491-0275 38.4 µM 0.603539461541989 0.247192166793928 no 841 0.273074936026072 1321 5104718 SGTC_398 bronopol 33.3 µM 0.603037317884247 0.247363830372974 no 842 0.273241931927386 1318 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2622 2-methoxyxanthone 59.94 µM 0.602737888193292 0.247466224172894 no 843 0.273341536131007 1379 71034 A hepatoprotective. SGTC_1887 st057648 70.8 µM 0.601261164468224 0.247971539796064 no 844 0.273833025793911 1349 688672 SGTC_1993 st073995 70.8 µM 0.595868383152121 0.249821546532693 no 845 0.275631578089229 1366 3098394 SGTC_1263 0774-1208 64.8 µM 0.595804852896717 0.249843384326002 no 846 0.275652800698416 1396 906585 SGTC_2979 9012552 45.46 µM 0.595575165144264 0.249922345298615 no 847 0.275729535777671 1393 17100905 SGTC_50 0929-0078 56.389 µM 0.595125329766559 0.250077025946183 no 848 0.275879849139113 1357 1377751 SGTC_1067 clotrimazole 1.36 µM 0.593271476923262 0.2507150284142 no 849 0.27649974213342 1352 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_628 1636-0253 16 µM 0.593044604855656 0.250793165471427 no 850 0.276575650697704 1343 4456143 SGTC_2824 7998404 51.95 µM 0.592781683443067 0.250883734417883 no 851 0.276663633700233 1360 837851 SGTC_2150 5556613 200 µM 0.592530647481186 0.250970225318448 no 852 0.276747652199432 1367 743190 SGTC_1529 apigenin 74 µM 0.591951554231332 0.251169803899119 no 853 0.276941514906858 1447 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2197 6588183 93.1375 µM 0.591524209009528 0.251317137881489 no 854 0.277084619641195 1327 884136 SGTC_615 k087-0205 167 µM 0.591470174142657 0.251335770504559 no 855 0.277102716828414 1289 9642773 SGTC_3333 9141820 12.094 µM 0.590914647106956 0.251527372970792 no 856 0.277288805725762 1346 1939433 SGTC_1738 st035555 74 µM 0.589969207940156 0.25185363432214 no 857 0.277605646752124 1355 5331140 SGTC_1022 4477-0945 21.3 µM 0.589874948269792 0.251886174609162 no 858 0.277637245290381 1340 4648966 SGTC_1513 0337-0559 19 µM 0.588966252557174 0.252199987975997 no 859 0.277941956175921 1279 775073 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.586655941018505 0.252998769680893 no 860 0.278717401935872 1394 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_3008 9078912 71.4286 µM 0.585768701902911 0.253305882739998 no 861 0.279015479437785 1333 16648731 SGTC_3321 9137793 26.8275 µM 0.583601277112242 0.254056948606357 no 862 0.279744300378658 1352 4904192 SGTC_1101 ebselen 5.29 µM 0.583459768358753 0.25410602545676 no 863 0.279791916391459 1418 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2930 9013230 14.89 µM 0.583340562809983 0.254147371159805 no 864 0.279832030692029 1387 2995857 SGTC_790 1575-0012 79.1 µM 0.582252250946874 0.254525008449505 no 865 0.280198391489583 1402 378741 YLR208W SEC13 SGTC_609 0986-0026 86.3 µM 0.582002315474107 0.25461177595846 no 866 0.280282560613423 1406 2848610 SGTC_1352 1496-0991 99 µM 0.58191790506936 0.254641083343608 no 867 0.280310989715873 1355 3000039 SGTC_2709 st078560 56 µM 0.581649575720019 0.254734259321901 no 868 0.280401371292294 1424 17250903 SGTC_1514 1189-1591 158 µM 0.581545222730076 0.254770500178326 no 869 0.280436524398531 1451 767698 YMR146C TIF34 SGTC_1336 1486-0901 104 µM 0.581410902120278 0.254817152493179 no 870 0.280481775755158 1404 5006114 SGTC_3238 9133470 49.47 µM 0.580265570074765 0.255215131468369 no 871 0.280867770892702 1438 3534688 SGTC_569 4130-2812 160 µM 0.579890749551179 0.255345444323841 no 872 0.280994147125807 1325 743552 SGTC_1907 st060210 83.7 µM 0.578622429965408 0.255786655436616 no 873 0.281421983349044 1433 688793 SGTC_339 3091-4833 71.4 µM 0.577187587560316 0.25628627430234 no 874 0.281906370560245 1369 3240077 SGTC_1795 st049545 62.3 µM 0.575924847967961 0.256726386626798 no 875 0.282332989757486 1348 5291882 SGTC_2219 9098279 200 µM 0.575582856640875 0.256845651167083 no 876 0.282448585669413 1380 902349 SGTC_1422 4031-0024 15.5 µM 0.574510274478516 0.257219885664121 no 877 0.282811274922143 1318 782427 SGTC_2037 5169046 200 µM 0.573999984574482 0.257398030307298 no 878 0.282983905856126 1395 5718022 SGTC_2804 7954240 19.48 µM 0.573849814061687 0.257450467757034 no 879 0.283034718131753 1405 828705 SGTC_1277 0873-0036 22 µM 0.573690710270688 0.257506030637309 no 880 0.283088557883374 1461 5965735 SGTC_442 cape 100 µM 0.573615519748005 0.257532291148161 no 881 0.283114003607378 1436 5281787 SGTC_983 1491-0821 12.2 µM 0.571791919746719 0.258169614508491 no 882 0.283731476054473 1401 46495113 SGTC_2270 7924575 90.91 µM 0.57108170670179 0.258418045349217 no 883 0.283972129141899 1460 1262135 SGTC_346 4513-0042 7.16 µM 0.56970219098009 0.25890095035856 no 884 0.284439851896606 1382 2827372 SGTC_1427 4048-4900 550 nM 0.5686814025095 0.259258581755878 no 885 0.284786185473175 1440 24132586 SGTC_591 4299-0174 154 µM 0.568423101114762 0.259349117641305 no 886 0.284873853979953 1390 5509088 SGTC_37 0566-0070 1.56 µM 0.568309552647222 0.259388922095267 no 887 0.284912396848794 1424 1626686 SGTC_604 1000-0114 314 µM 0.567215256999674 0.259772689510758 no 888 0.285283971782585 1463 1572745 SGTC_951 1171-0579 82.7 µM 0.567142659359788 0.259798159725535 no 889 0.285308630929277 1339 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1938 st074717 56.4 µM 0.566080968596512 0.260170791335137 no 890 0.285669370012941 1311 17250979 SGTC_1703 st026983 48.3 µM 0.561803191495275 0.261674989289703 no 891 0.287125058706861 1448 1104023 SGTC_3169 9102970 49.47 µM 0.561581362570241 0.261753112692253 no 892 0.287200640757924 1439 17027839 SGTC_2704 st078022 71.1 µM 0.561390775009747 0.261820243109852 no 893 0.287265585701375 1476 54697681 SGTC_2567 aureobasidin a 60 nM 0.561319250817666 0.261845438265099 no 894 0.287289960200907 1477 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3292 9120825 59.784 µM 0.56101243265002 0.261953532325644 no 895 0.287394530879971 1434 24824900 SGTC_685 1278-0033 54.9 µM 0.560574565504356 0.262107835419079 no 896 0.287543797235489 1466 3590572 SGTC_1329 1447-1697 50.6 µM 0.560487684461652 0.262138457580154 no 897 0.287573418833368 1384 2840515 SGTC_1725 st036284 20.55 µM 0.559760274753078 0.262394912893484 no 898 0.287821481622181 1526 707914 SGTC_878 0828-0289 13.7 µM 0.55918394935489 0.262598193153924 no 899 0.288018093055999 1407 745350 YLR208W SEC13 SGTC_3102 9121669 49.47 µM 0.558953311003464 0.262679565992839 no 900 0.288096792296446 1448 41905072 SGTC_1417 3966-0327 90.4 µM 0.55801226867861 0.263011714181399 no 901 0.28841800323774 1442 651118 SGTC_1666 st014829 29 µM 0.557996383291995 0.263017322893694 no 902 0.288423426929167 1391 3858230 SGTC_840 0245-0196 390 µM 0.557347112255972 0.26324661572231 no 903 0.288645146372988 1476 3827528 SGTC_2337 9009472 200 µM 0.553827567307162 0.264491332269362 no 904 0.28984842999234 1491 5742383 SGTC_433 pimozide 108 µM 0.552872154535046 0.264829738101622 no 905 0.290175477968207 1347 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_581 0958-0271 211 µM 0.55212040974785 0.265096159664152 no 906 0.290432929703599 1388 4591145 SGTC_2274 7947094 46.08 µM 0.551828686659667 0.265199584226214 no 907 0.29053286555934 1386 2971028 SGTC_2444 5485484 36.41 µM 0.550629549395666 0.26562492935863 no 908 0.290943824079554 1503 6790631 SGTC_2735 sertaconazole 140 nM 0.550392319278381 0.265709118059709 no 909 0.291025157820628 1467 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3250 9135583 49.47 µM 0.54992347030073 0.26587554390782 no 910 0.291185932730771 1466 7699353 SGTC_2190 6049624 200 µM 0.549110682133478 0.266164181878649 no 911 0.291464747445911 1403 2265554 SGTC_210 3551-0445 56.827 µM 0.548576733490994 0.266353884447271 no 912 0.291647978218339 1455 2865180 YOR207C RET1 SGTC_2218 6965428 192.983 µM 0.548193519934138 0.266490075648329 no 913 0.291779515557908 1442 675684 SGTC_2125 5246583 200 µM 0.547965382573822 0.266571170664593 no 914 0.291857836406094 1493 835267 SGTC_549 1661-1316 519 µM 0.546937262836747 0.266936786785399 no 915 0.292210917188316 1490 2857282 SGTC_110 0850-0284 111.64 µM 0.546595714023643 0.267058303132572 no 916 0.292328257137812 1299 3906265 SGTC_1643 st009866 20.2 µM 0.546444783924536 0.267112009989383 no 917 0.29238011653129 1419 3156273 YOR207C RET1 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.546415095449073 0.267122574956673 no 918 0.292390317957819 1414 77254 SGTC_3278 9139605 49.47 µM 0.542874214982856 0.268384146909822 no 919 0.293608205231444 1463 7958859 SGTC_3038 9091290 49.47 µM 0.54156112200669 0.268852746159765 no 920 0.294060440296401 1465 25236843 SGTC_3190 9110366 49.47 µM 0.541289396982088 0.268949767075902 no 921 0.294154063796818 1432 17123768 SGTC_2047 4141938 200 µM 0.539811156524098 0.269477888697211 no 922 0.294663636165519 1439 3807862 SGTC_2877 9040724 71.43 µM 0.538989246834822 0.269771751854447 no 923 0.294947137173886 1504 6463895 SGTC_882 0843-0131 351 µM 0.538736642709816 0.269862099413309 no 924 0.295034293065102 1427 5425421 SGTC_921 1561-0023 372 µM 0.53840598470129 0.269980386972338 no 925 0.295148397778796 1415 24050882 SGTC_220 paclitaxel 373.376 µM 0.537997479053778 0.270126559086926 no 926 0.295289394501794 1456 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1623 st003709 20.3 µM 0.537567630297024 0.270280410957394 no 927 0.295437791312842 1408 16192618 SGTC_1929 genistein trimethyl ether 50.5 µM 0.537171014998212 0.270422406728666 no 928 0.295574745347752 1548 136420 SGTC_3091 9116372 49.47 µM 0.535023911142639 0.271191757111171 no 929 0.296316661514588 1416 17169793 SGTC_2201 6605497 169.863 µM 0.534591345419633 0.271346886055871 no 930 0.296466234749292 1468 670741 SGTC_71 0417-1750 47.813 µM 0.534322793167275 0.271443217890149 no 931 0.296559112562107 1573 6811472 SGTC_329 k048-0121 21.3 µM 0.534152786938563 0.271504209285311 no 932 0.296617915483289 1426 6832902 SGTC_781 4335-2806 94.4 µM 0.534131736776935 0.271511761711306 no 933 0.296625196829231 1557 845254 SGTC_514 4466-0038 2.65 nM 0.533636528569847 0.271689463844968 no 934 0.296796515196164 1452 5722064 SGTC_3345 9148410 3.559 µM 0.531696031699215 0.272386355542621 no 935 0.297468270410356 1473 4903596 SGTC_321 4534-3890 65.3 µM 0.529299298624025 0.273248319397181 no 936 0.298298921034979 1475 699746 SGTC_986 1493-0483 84 µM 0.529197238502787 0.273285054390564 no 937 0.29833431607384 1415 40079 SGTC_1969 st069479 40.1 µM 0.527987707494287 0.273720592928469 no 938 0.298753933912366 1520 3895485 SGTC_2225 6654152 15.4 µM 0.52574544477364 0.274528913709629 no 939 0.299532542059603 1475 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1884 5633444 25 µM 0.52554854183964 0.274599952118634 no 940 0.299600958966527 1458 5724239 SGTC_1641 st009299 47.1 µM 0.524588798081823 0.274946337098347 no 941 0.299934537798383 1412 4046054 SGTC_3144 9087057 49.47 µM 0.524563641081536 0.274955419507323 no 942 0.299943283895534 1455 17249618 SGTC_3316 9136639 10.545 µM 0.524233006204557 0.275074802053867 no 943 0.300058243331843 1504 4903665 SGTC_1144 3486-0183 12.5 µM 0.523698789007257 0.275267746132571 no 944 0.300244029024613 1440 6744069 SGTC_3146 9095609 49.47 µM 0.523144593060235 0.275467976342967 no 945 0.300436817700106 1508 17173999 SGTC_1644 st010134 20.9 µM 0.522506393644645 0.275698645612191 no 946 0.300658897994811 1423 3818134 SGTC_2854 9024559 71.43 µM 0.522183874443208 0.275815252285022 no 947 0.300771156233287 1409 3163529 SGTC_779 1360-0071 233 µM 0.522183109915616 0.27581552872842 no 948 0.300771422362454 1609 7566 SGTC_2496 diffractaic acid 79.83 µM 0.521804267541082 0.275952530031257 no 949 0.300903309030337 1568 94870 An apoptosis inducer which activates caspases. SGTC_3023 9089636 49.47 µM 0.521609461068117 0.276022991181241 no 950 0.300971137299608 1517 17249241 SGTC_2517 totarol 10 µM 0.521113844959539 0.276202294454726 no 951 0.301143733389656 1386 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_188 3229-0966 278.469 µM 0.519511188734865 0.276782492072934 no 952 0.301702156257634 1563 5722370 SGTC_1913 st060213 96.1 µM 0.519363167415448 0.276836109224108 no 953 0.301753755670232 1517 688959 SGTC_3087 9117406 49.47 µM 0.5191080684357 0.27692852461032 no 954 0.30184269107144 1428 42546093 SGTC_369 0957-0393 4.5 µM 0.5172821120801 0.277590459354837 no 955 0.302479619599622 1411 6997992 SGTC_3151 9099821 49.47 µM 0.517022295681788 0.277684709224858 no 956 0.302570297483115 1419 17174189 SGTC_2115 tiliquinol 12.7705 µM 0.516460120690173 0.277888694870986 no 957 0.30276654248602 1478 71208 A bioactive hydroxyquinoline. SGTC_2334 9017922 200 µM 0.516129213548479 0.278008798981121 no 958 0.302882082760864 1590 3163164 SGTC_1454 4239-0054 42.6 µM 0.51528816820656 0.278314173801864 no 959 0.303175832827131 1556 1340767 SGTC_248 streptozotocin 5.23457 mM 0.512878031487501 0.27919017395848 no 960 0.304018320749561 1542 5300 DNA alkylating agent. SGTC_853 0419-0306 21 µM 0.512521662757448 0.279319815138362 no 961 0.304142981599533 1397 762713 SGTC_2091 4-phenylthiadiazole 200 µM 0.512265536028687 0.279413007961011 no 962 0.304232590999125 1477 270010 SGTC_474 dl-dihydrosphingosine 5 µM 0.511861274389475 0.279560131038203 no 963 0.304374051323754 1499 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1114 scopoletin 1.73284 µM 0.510825658141573 0.279937194705777 no 964 0.304736570473818 1529 5280460 A coumarin with genotoxic properties. SGTC_3177 9107506 49.47 µM 0.507177801619177 0.281267325178177 no 965 0.306015034549351 1488 8897194 SGTC_1630 st005209 31.3 µM 0.505233234157309 0.281977624164661 no 966 0.306697515204887 1496 3367314 SGTC_261 5-fluorouridine 15.376 µM 0.503027502616741 0.282784363843776 no 967 0.307472467985085 1540 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2446 5162541 200 µM 0.502363049328791 0.283027602767624 no 968 0.30770608305534 1423 1549321 SGTC_2268 7933382 153.85 µM 0.501868695139461 0.283208638002619 no 969 0.307879943602945 1465 935025 YOR257W CDC31 SGTC_718 1130-0073 349 µM 0.501269892672158 0.283427997140645 no 970 0.308090595575026 1546 6740020 SGTC_751 0833-0568 350 µM 0.501077225890604 0.283498594022877 no 971 0.308158387031323 1500 6954252 SGTC_1809 st050081 57.6 µM 0.500721904502804 0.283628812836756 no 972 0.308283427067235 1551 5036894 SGTC_1086 cerivastatin 2.18 µM 0.500406093006981 0.283744576041183 no 973 0.308394581976642 1500 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_111 0083-0039 52.457 µM 0.499518159689499 0.284070176210229 no 974 0.308707198422187 1437 759313 SGTC_2549 cedrol 20.94 µM 0.499447564696994 0.284096070665819 no 975 0.308732058895278 1531 6708665 A sedative which affects the nervous system. SGTC_464 bw-b 70c 158 µM 0.498405693115444 0.284478363520102 no 976 0.309099062442973 1536 5353454 SGTC_1257 0669-0121 16 µM 0.496808131955002 0.285065031818926 no 977 0.309662180071342 1586 4307855 SGTC_2898 9056270 58.44 µM 0.495429615465521 0.285571724048981 no 978 0.310148446962035 1472 19154699 SGTC_2097 5376186 200 µM 0.493857418575752 0.286150128797083 no 979 0.310703439405141 1548 742755 SGTC_1896 st058441 89 µM 0.493675618025043 0.286217048348753 no 980 0.310767643628272 1433 688759 SGTC_1629 st005085 44.9 µM 0.492451157580638 0.286667957440881 no 981 0.311200221015217 1436 24207091 SGTC_86 0417-1630 471.922 µM 0.49164932004474 0.286963417518794 no 982 0.311483635586356 1516 3634867 SGTC_2108 5365811 200 µM 0.490376691668425 0.28743264995813 no 983 0.311933683547803 1556 780283 SGTC_1988 st071872 53.4 µM 0.490021359204068 0.28756372982403 no 984 0.312059392306314 1530 16414116 SGTC_198 3454-2873 16.191 µM 0.48967488286579 0.287691569927612 no 985 0.312181989042397 1483 710957 SGTC_3200 9114385 49.47 µM 0.486619373913441 0.28882012857544 no 986 0.313264045692904 1463 17018030 YLR208W SEC13 SGTC_403 arphamenine a 50 µM 0.484379335990323 0.289648812952726 no 987 0.31405834040781 1549 5487158 An arginine aminopeptidase inhibitor. SGTC_2288 7946289 167.31 µM 0.483950330250481 0.289807647496437 no 988 0.314210559969979 1637 1246052 SGTC_2483 5729050 27.16 µM 0.483199084043762 0.290085886329259 no 989 0.314477192824824 1643 2865180 SGTC_1057 3448-5381 134 µM 0.482453593365316 0.290362117192558 no 990 0.314741878619681 1610 5497911 SGTC_3210 9128157 49.47 µM 0.482390565875759 0.290385476769114 no 991 0.314764260840016 1465 17590849 SGTC_1456 k015-0012 13 µM 0.480560758119011 0.291064032906861 no 992 0.31541435560363 1675 2989616 SGTC_2593 nobiletin 86.24 µM 0.4792905125537 0.291535519098865 no 993 0.315865985317324 1465 72344 An anti-infammatory. SGTC_2702 st077768 96.8 µM 0.476695945338839 0.292499668392061 no 994 0.316789325281656 1477 6484119 SGTC_2770 toltrazuril 17.5 µM 0.475541555784419 0.292929119006424 no 995 0.317200510534777 1536 68591 Kills coccidiodes. SGTC_3207 9114163 49.47 µM 0.473945060889308 0.293523521273306 no 996 0.317769542491055 1687 849233 SGTC_1131 3454-3128 32.3 µM 0.472531485788029 0.294050285157335 no 997 0.318273736674087 1620 710982 SGTC_1061 3448-9325 110 µM 0.471425849703302 0.294462600941032 no 998 0.318668329963117 1514 723482 SGTC_1093 fluphenazine 7.97 µM 0.469225755269716 0.295283856923289 no 999 0.319454138909611 1560 6602611 An atypical antipsychotic. SGTC_903 1134-0042 114 µM 0.469129108422022 0.295319957625189 no 1000 0.319488676949589 1502 701009 SGTC_1320 1313-0481 95.3 µM 0.468590472500784 0.295521192634792 no 1001 0.319681194356987 1592 6813365 YLR208W SEC13 SGTC_945 3381-0768 11.3 µM 0.468351206366822 0.295610602963528 no 1002 0.319766727630563 1538 1126236 YIL048W NEO1 SGTC_2031 5180455 200 µM 0.468156148562191 0.295683502472399 no 1003 0.319836464326341 1497 29949 SGTC_2259 7964009 200 µM 0.468118386427036 0.295697616377239 no 1004 0.319849965709025 1559 313134 SGTC_5 0352-0601 109.883 µM 0.466504657471532 0.296301049774291 no 1005 0.320427157297635 1514 762456 SGTC_3161 9100388 49.47 µM 0.466152785023952 0.296432702948624 no 1006 0.320553071276922 1592 25236368 SGTC_2840 9008771 71.43 µM 0.465995140383521 0.296491694430395 no 1007 0.320609489509866 1659 2992978 SGTC_185 k048-0037 25.491 µM 0.4652238701461 0.296780385461048 no 1008 0.32088557323077 1587 6827589 SGTC_2462 5162487 171.77 µM 0.464680201359326 0.296983961207328 no 1009 0.32108024433176 1542 2259986 SGTC_2130 NSC 7 2.4545 µM 0.463963279348877 0.297252508906996 no 1010 0.321337027281203 1641 21448 SGTC_3003 9075612 71.4286 µM 0.462279447032118 0.297883681984692 no 1011 0.321940468292208 1538 6501993 SGTC_3227 9130768 49.47 µM 0.462255396629623 0.297892701539215 no 1012 0.321949090727958 1564 17720899 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.460909631695831 0.298397598255137 no 1013 0.32243172060178 1551 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_45 0kpi-0036 14.9 µM 0.460703531494681 0.298474956177131 no 1014 0.322505660499961 1575 2795021 SGTC_216 k038-0035 28.382 µM 0.460276361155648 0.298635319904594 no 1015 0.322658933220159 1529 4444231 YPR107C YTH1 SGTC_3039 9090270 49.47 µM 0.45995789707771 0.298754899774355 no 1016 0.322773220726702 1604 17173750 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.454340202234005 0.300867852275122 no 1017 0.32479199233042 1609 688751 SGTC_3228 9131799 49.47 µM 0.453783900495157 0.301077457261083 no 1018 0.324992186176216 1583 17015818 SGTC_3268 9137683 49.47 µM 0.45327401270817 0.301269632046421 no 1019 0.325175721633575 1558 1953228 SGTC_2220 6782180 200 µM 0.453188319531297 0.301301934903424 no 1020 0.325206571284271 1561 833803 SGTC_2683 piperine 63.03 µM 0.450969883776929 0.302138737552847 no 1021 0.326005627385756 1549 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_804 1595-0054 20.9 µM 0.45057988160456 0.302285955663184 no 1022 0.326146184620929 1529 761523 Stimulates phospholipase C. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.449084963525511 0.302850555558842 no 1023 0.326685183491789 1637 756377 SGTC_544 k015-0020 52.4 µM 0.447037957456076 0.303624432665349 no 1024 0.327423826951805 1574 3008304 SGTC_935 2996-0153 430 µM 0.44650872081301 0.303824655789504 no 1025 0.327614907282923 1672 23738523 SGTC_821 1114-0266 29.2 µM 0.445383153118295 0.304250681204065 no 1026 0.328021442410535 1543 3123235 SGTC_1439 4092-1168 46 µM 0.445298868453754 0.304282593508243 no 1027 0.328051892748459 1576 2886240 SGTC_2846 9008642 19.48 µM 0.4423867395504 0.305386113218815 no 1028 0.329104686515634 1550 2992898 SGTC_2023 5144124 124 µM 0.441243095705319 0.30581996952092 no 1029 0.329518508549476 1537 2830192 SGTC_1179 1021-1431 9.29 µM 0.44116109175607 0.305851089278704 no 1030 0.329548189315591 1587 2840958 SGTC_802 4112-3352 742 µM 0.438987647544358 0.306676402110608 no 1031 0.330335243397624 1667 704594 SGTC_2885 9057732 51.95 µM 0.438334108620618 0.306924759763063 no 1032 0.33057205191303 1580 6471414 SGTC_2152 5568786 200 µM 0.438213606782252 0.306970562514309 no 1033 0.330615722922718 1557 5399883 SGTC_1175 0741-0056 27.6 µM 0.436816532538389 0.307501810269526 no 1034 0.331122204112831 1675 765927 SGTC_1475 4092-1048 11.7 µM 0.436623081343946 0.307575403379065 no 1035 0.331192360343806 1548 2881759 SGTC_2425 5628681 7.85 µM 0.435790130679505 0.307892364659044 no 1036 0.331494502540299 1661 5714958 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.435754347577256 0.307905984355092 no 1037 0.331507484861474 1627 5377381 SGTC_1089 terbinafine 2.25 µM 0.435122138085945 0.308146658350281 no 1038 0.331736887575237 1633 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2214 7179297 48.276 µM 0.434390833578572 0.308425159469249 no 1039 0.332002326502081 1628 769744 SGTC_1437 4092-1038 11.6 µM 0.434150913580231 0.308516551717218 no 1040 0.332089427766146 1544 3977136 SGTC_1445 4239-0156 97.7 µM 0.432451350571474 0.309164302346855 no 1041 0.33270670168419 1713 4008346 SGTC_959 1222-0044 107 µM 0.431157731288143 0.309657734625033 no 1042 0.333176842869633 1679 6083612 SGTC_1735 st034310 56.75 µM 0.430285315532263 0.309990698799634 no 1043 0.333494053822862 1667 871153 SGTC_1843 st055809 45.5 µM 0.429247879493165 0.310386847142143 no 1044 0.333871421267581 1567 16413835 SGTC_695 3505-6186 243 µM 0.429078892604223 0.31045139619243 no 1045 0.333932906190659 1630 1819379 SGTC_3100 9120536 49.47 µM 0.428931464152084 0.310507715190929 no 1046 0.333986550840051 1594 16421196 SGTC_2014 4013930 200 µM 0.42791876923417 0.31089469378519 no 1047 0.334355130802887 1573 64556 SGTC_572 0960-0087 17.7 µM 0.426625093547107 0.311389347209694 no 1048 0.334826208750186 1511 6796365 SGTC_1310 1188-0297 994 nM 0.426550094833381 0.311418034382635 no 1049 0.334853526698728 1585 1588352 SGTC_2118 5526350 200 µM 0.425900828939682 0.311666427863982 no 1050 0.335090055435849 1640 743594 SGTC_3294 9122953 26.2835 µM 0.425392393572452 0.311861002833724 no 1051 0.335275325032189 1543 16459826 SGTC_1560 lithocholic acid 53.1 µM 0.425366168306147 0.31187104050059 no 1052 0.335284882387133 1631 9903 A bile acid which acts as a detergent. SGTC_762 1165-0429 115 µM 0.422433804703397 0.312994276544783 no 1053 0.33635420391559 1685 5967793 SGTC_3349 9149703 23.001 µM 0.422022232259508 0.313152067869342 no 1054 0.336504394982684 1546 4910494 SGTC_2082 5219693 150 µM 0.42190034382642 0.313198804820159 no 1055 0.33654887953302 1553 2834649 SGTC_2767 sibutramine 71.45 µM 0.421780861271055 0.313244622172872 no 1056 0.336592488251689 1709 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_153 4077-0274 519.67 µM 0.421048699528511 0.313525443359405 no 1057 0.336859760471581 1715 3121976 SGTC_2769 toremifene 3.73 µM 0.42074400713826 0.313642340222476 no 1058 0.336971011293005 1623 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2984 9022109 38.96 µM 0.420151849368921 0.313869578235376 no 1059 0.337187263710782 1628 6459207 SGTC_971 1315-0384 26.7 µM 0.420126146818665 0.313879443078773 no 1060 0.337196651344832 1553 6769120 SGTC_374 0880-0231 82.3 µM 0.41829870877306 0.314581168984153 no 1061 0.33786436679646 1627 6833587 SGTC_532 1548-0774 215 µM 0.418281190132592 0.31458789929091 no 1062 0.337870770290016 1710 5932993 SGTC_1821 st053465 65.6 µM 0.416381516940486 0.315318080410314 no 1063 0.338565425595708 1566 675086 SGTC_53 0973-0023 39.979 µM 0.415671677581204 0.315591108202056 no 1064 0.338825134414194 1724 674768 SGTC_1523 st012844 44.7 µM 0.414584210987488 0.316009579223131 no 1065 0.339223154258862 1615 4274103 SGTC_2801 7907800 81.82 µM 0.414321623199752 0.316110661727187 no 1066 0.339319290014116 1592 6620925 SGTC_1673 st016611 27.3 µM 0.413081013024116 0.316588417271426 no 1067 0.33977362993306 1692 5226799 SGTC_3156 9099931 49.47 µM 0.412628373142687 0.316762803909417 no 1068 0.339939455064244 1640 18111053 SGTC_515 4092-1064 102 µM 0.411823741827187 0.317072901315192 no 1069 0.340234309106684 1731 717353 SGTC_2685 mycophenolic acid 18.85 µM 0.411766386875014 0.317095010287989 no 1070 0.340255330340669 1657 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_6 0844-0013 19.835 µM 0.411271523283558 0.317285795570446 no 1071 0.340436724018485 1676 1584900 SGTC_2967 9089538 49.85 µM 0.410165985625491 0.317712190042629 no 1072 0.34084209536048 1785 728216 SGTC_1094 duloxetine 25.4 µM 0.409992741668165 0.317779030386285 no 1073 0.340905635999301 1617 60834 A selective serotonin reuptake inhibitor. SGTC_2691 st077356 60.2 µM 0.409975167782215 0.317785811009833 no 1074 0.340912081820808 1710 2839272 SGTC_734 2023-0417 80 µM 0.409492197180368 0.317972181970843 no 1075 0.341089245916871 1665 3935732 SGTC_2069 5228469 200 µM 0.409172749738085 0.318095477187201 no 1076 0.341206445425756 1580 2835210 SGTC_2998 9066762 71.4286 µM 0.406936352575478 0.318959210025523 no 1077 0.342027367734678 1701 4945196 SGTC_1404 3909-7820 48.3 µM 0.406544246139417 0.319110749409732 no 1078 0.342171376756533 1699 23741373 SGTC_936 3005-4620 401 µM 0.404543063760708 0.319884627089019 no 1079 0.342906708665092 1728 777207 SGTC_2293 7624732 200 µM 0.404170015709895 0.320028975442149 no 1080 0.343043850624614 1544 894453 SGTC_1084 voriconazole 435 nM 0.403225890717993 0.320394419764334 no 1081 0.34339102736239 1699 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_227 fluconazole 33.516 µM 0.401762963510092 0.320961021947036 no 1082 0.34392924077249 1583 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2763 lisinopril 49.32 µM 0.4011793606777 0.321187171990238 no 1083 0.34414403759674 1643 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1230 0170-0365 3.77 µM 0.400347554472948 0.32150961714537 no 1084 0.344450273354297 1692 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_95 0471-0001 561.058 µM 0.399896837154847 0.321684391480257 no 1085 0.344616250968946 1540 4015405 SGTC_2988 9073640 71.4286 µM 0.397946033309547 0.322441308008704 no 1086 0.345334983273956 1659 9102229 SGTC_1968 st069590 43.6 µM 0.397724007667593 0.322527501232955 no 1087 0.345416819335186 1703 6384066 SGTC_2678 equilin 100 µM 0.397460185906321 0.322629932652911 no 1088 0.34551407035365 1720 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1045 1348-1485 165 µM 0.395874508465676 0.32324587106759 no 1089 0.346098803678709 1597 6810614 SGTC_2182 6325192 200 µM 0.394501690000026 0.323779518514638 no 1090 0.346605339864201 1637 736248 SGTC_195 4234-0266 16.654 µM 0.394156180527248 0.323913883467738 no 1091 0.346732867598956 1629 2303354 SGTC_228 caffeine 993.056 µM 0.393312666268211 0.324242013548692 no 1092 0.347044282107641 1700 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1670 st016595 4.04 µM 0.3914149795723 0.324980719376103 no 1093 0.347745260841684 1650 597879 SGTC_850 0388-0143 75.9 µM 0.389097480066912 0.325883778117657 no 1094 0.348602018756289 1618 67273 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.387449551142411 0.326526548049446 no 1095 0.349211713121181 1612 688664 SGTC_163 TUB2.036 7.546 µM 0.387026496575917 0.326691642477515 no 1096 0.349368296084478 1664 15992207 YJR013W GPI14 SGTC_3022 9087993 49.47 µM 0.386603127511052 0.326856893617106 no 1097 0.349525021119943 1689 17173644 SGTC_3110 9122132 49.47 µM 0.386318200774294 0.326968126505684 no 1098 0.349630511274272 1734 918317 SGTC_2085 5307070 144.047 µM 0.385880527605318 0.327139020201868 no 1099 0.349792576282934 1617 2840351 SGTC_2610 ononetin 44.17 µM 0.385663897689467 0.327223618847871 no 1100 0.349872801813929 1604 259632 SGTC_1699 st031318 29.054 µM 0.385364495143014 0.327340556599516 no 1101 0.349983691938566 1700 5340658 SGTC_1483 3453-0561 55.9 µM 0.385327484546441 0.327355013017538 no 1102 0.349997400491863 1689 4546991 SGTC_1908 st060353 56.5 µM 0.384991179447541 0.327486386370843 no 1103 0.350121975297962 1833 4227716 SGTC_373 0844-0104 25.9 µM 0.384980845693534 0.327490423460169 no 1104 0.350125803403247 1768 5375804 SGTC_1010 4112-3296 15.2 µM 0.384030584554689 0.327861748294985 no 1105 0.350477889571589 1805 704384 SGTC_2322 7413319 38.22 µM 0.383026438812961 0.328254314135268 no 1106 0.350850080444582 1678 1840400 SGTC_193 1273-0060 1.558 µM 0.382831592776746 0.328330510228476 no 1107 0.350922317549954 1676 2847393 YHR072W ERG7 SGTC_1736 st036774 51 µM 0.382360765590796 0.328514660420549 no 1108 0.351096893983202 1834 1272247 SGTC_896 0964-0007 44.5 µM 0.382046681359987 0.328637528389169 no 1109 0.351213369701084 1737 6756758 SGTC_409 arachidonic acid 100 µM 0.381950530022696 0.328675145951532 no 1110 0.351249029478816 1663 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3344 9148862 3.898 µM 0.381091463784561 0.329011317901366 no 1111 0.351567690635898 1733 4905352 SGTC_1066 ketoconazole 628 nM 0.380628109785437 0.329192696199722 no 1112 0.351739610026805 1732 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_991 3996-0057 64.7 µM 0.379208725739994 0.329748559218024 no 1113 0.352266436213997 1664 715343 SGTC_448 monastrol 171 µM 0.378386931772241 0.330070564465183 no 1114 0.352571587374272 1681 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3143 9086658 49.47 µM 0.378331711499247 0.33009220605779 no 1115 0.352592095347096 1643 25236626 SGTC_1600 coumarin 106 71.1 µM 0.377772272436069 0.330311490050281 no 1116 0.352799886688554 1689 100336 A hepatotoxic, DNA x-linker. SGTC_2291 7917025 104.35 µM 0.37730290504942 0.330495513511972 no 1117 0.352974256770044 1597 2964612 SGTC_350 k064-0020 19.8 µM 0.376741472922002 0.330715686359318 no 1118 0.353182869481906 1772 2790705 SGTC_2526 patulin 37.61 µM 0.376011299432716 0.331002120941724 no 1119 0.353454247844251 1704 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_525 k781-2675 26.7 µM 0.375839767590768 0.331069424310483 no 1120 0.353518010671725 1680 3651118 YDL195W SEC31 SGTC_661 1304-0007 33.6 µM 0.375656055811738 0.331141512733988 no 1121 0.353586305656204 1632 3117130 SGTC_3037 9091026 49.47 µM 0.374984384391512 0.331405129571845 no 1122 0.353836040087838 1703 25236398 YIL048W NEO1 SGTC_2206 7254556 146.969 µM 0.374717928492304 0.331509731036156 no 1123 0.353935128600504 1734 4398905 SGTC_386 1509-0011 3.07 µM 0.374594243174017 0.331558290124642 no 1124 0.353981127545401 1645 3107280 SGTC_624 k048-0052 28 µM 0.374449168108262 0.331615250476058 no 1125 0.354035084118188 1668 6835531 SGTC_2858 9025781 8.96 µM 0.374282839362385 0.331680560382134 no 1126 0.354096949003649 1721 4894980 YPL153C RAD53 SGTC_1974 st069448 26.9 µM 0.373520730285619 0.331979872151496 no 1127 0.354380459703501 1773 6323587 YNR016C ACC1 SGTC_1819 st053448 58.6 µM 0.372416891855539 0.332413585313397 no 1128 0.354791239552028 1689 2857616 SGTC_229 benomyl 22.8748 µM 0.371466233119321 0.332787292040407 no 1129 0.355145150853966 1652 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_3139 9095020 49.47 µM 0.371304700920434 0.332850807347733 no 1130 0.355205298504408 1591 25236292 SGTC_278 4092-0821 23.9 µM 0.371293452126719 0.332855230611057 no 1131 0.355209487206247 1730 877900 SGTC_1769 st044406 64.4 µM 0.368396744550962 0.333995049966787 no 1132 0.356288712259117 1671 670903 SGTC_3222 9128301 49.47 µM 0.36839017328881 0.333997637425566 no 1133 0.356291161824267 1652 4911358 SGTC_2275 7947463 200 µM 0.367048582013882 0.334526059063933 no 1134 0.3567913899964 1756 1225414 SGTC_2464 5717415 7.67 µM 0.366409787575023 0.334777780681592 no 1135 0.357029658693267 1590 5285744 SGTC_392 N-ethylmaleimide 8.33 µM 0.366133018593921 0.334886866586376 no 1136 0.357132910140512 1656 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1958 st076513 41.9 µM 0.365239714388694 0.335239049101878 no 1137 0.357466237596089 1642 732122 YGL099W LSG1 SGTC_2585 alliin 100 µM 0.364810232958603 0.335408422461834 no 1138 0.357626532993814 1777 87310 A garlic compound which reacts with lipids. SGTC_334 1502-1024 68.5 µM 0.363888309657437 0.335772111669752 no 1139 0.357970707313732 1703 3296216 SGTC_2805 7950783 58.44 µM 0.363806852590498 0.335804253043169 no 1140 0.358001122591211 1710 1178958 YDL195W SEC31 SGTC_2388 9080168 200 µM 0.363717593569343 0.335839474295017 no 1141 0.358034452077588 1602 15943073 SGTC_416 estradiol valerate 100 µM 0.363466404010081 0.33593860042546 no 1142 0.358128252537959 1698 13791 A steroid. SGTC_1480 1070-0044 41.2 µM 0.36291919855697 0.336154581863778 no 1143 0.358332622375634 1744 3124987 SGTC_2164 5685496 200 µM 0.362913827967278 0.336156701898287 no 1144 0.358334628380236 1757 759046 SGTC_947 3447-0010 211 µM 0.362586127537178 0.336286071148744 no 1145 0.358457037338756 1656 748350 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.361873365845564 0.336567521431813 no 1146 0.358723331984069 1795 94937 An inhibitor of serotonin biosynthesis. SGTC_24 0417-1663 219 µM 0.361096018286913 0.336874579331142 no 1147 0.359013834841471 1680 4329390 SGTC_1305 1181-0477 144 µM 0.360090283636044 0.337272013138281 no 1148 0.359389809321643 1790 6252086 SGTC_2682 pyrogallin 40.03 µM 0.359876300759553 0.337356595701448 no 1149 0.359469820269637 1731 822798 An ATP competetive kinase inhibitor. SGTC_1808 st050063 61.5 µM 0.359773171962195 0.337397363104627 no 1150 0.359508383653158 1765 4011993 SGTC_40 0327-0103 19.753 µM 0.359687772840249 0.337431123310597 no 1151 0.35954031838785 1645 409036 SGTC_3251 9135047 49.47 µM 0.359192863774716 0.337626797827902 no 1152 0.359725407394497 1804 17682963 SGTC_1235 benzylparaben 21.5 µM 0.358328961462879 0.33796846812111 no 1153 0.360048573497201 1701 7180 SGTC_666 0272-0154 136 µM 0.357438166420856 0.338320914230037 no 1154 0.360381904328741 1710 6870312 SGTC_537 1334-0398 209 µM 0.357367672138061 0.338348811589008 no 1155 0.360408287455151 1808 5846986 SGTC_1708 st033234 31.827 µM 0.356811930926669 0.338568771294625 no 1156 0.360616301922356 1769 674664 SGTC_1065 prochlorperazine maleate 2.48 µM 0.356550896658938 0.33867210642208 no 1157 0.360714021540774 1700 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2727 riluzole 51.77 µM 0.355605021996545 0.33904664967596 no 1158 0.361068191088117 1724 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_571 k831-0106 44.2 µM 0.355333355528817 0.339154252392336 no 1159 0.361169934836789 1798 4783639 SGTC_1180 1193-0155 285 µM 0.353094873817855 0.340041377737369 no 1160 0.362008657899786 1671 2921347 SGTC_128 0906-2981 13.371 µM 0.352019897358738 0.34046771348185 no 1161 0.3624116702114 1788 6740226 SGTC_157 1348-1695 65.819 µM 0.351515400204148 0.340667867443604 no 1162 0.362600860517274 1681 5380510 SGTC_1772 st048439 82.2 µM 0.350331686106975 0.341137669691019 no 1163 0.36304489404094 1698 2927068 YDL195W SEC31 SGTC_998 3996-0085 177 µM 0.350146025708734 0.341211378497027 no 1164 0.3631145554872 1819 715391 SGTC_2359 9039622 200 µM 0.348997445957739 0.341667509324209 no 1165 0.363545613498607 1768 6463596 SGTC_1027 k015-0025 8.67 µM 0.348271012507648 0.341956114346824 no 1166 0.363818330712 1657 3598955 SGTC_2465 5809242 33.21 µM 0.347681259701029 0.342190485411872 no 1167 0.364039786116623 1756 2731748 SGTC_3152 9099253 49.47 µM 0.346850067144132 0.342520909207114 no 1168 0.364351980558888 1771 25236131 SGTC_2744 captopril 92.04 µM 0.34639766367992 0.342700803738382 no 1169 0.364521940336858 1823 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2234 tolnaftate 200 µM 0.346348822250739 0.342720227267087 no 1170 0.364540290769773 1752 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1477 0139-0234 16 µM 0.345878277635127 0.342907377335942 no 1171 0.364717097098305 1748 620880 SGTC_766 1391-0721 126 µM 0.345379738097662 0.343105703907412 no 1172 0.364904453866638 1810 1020919 YIL115C NUP159 SGTC_1871 st057448 67.3 µM 0.345281666271569 0.34314472345366 no 1173 0.364941314161401 1798 691747 SGTC_1830 st055982 50.3 µM 0.345166661755264 0.343190482089635 no 1174 0.36498454019764 1848 455313 An antimicrobial agent. SGTC_1882 5615643 20 µM 0.345122979067081 0.343207863402907 no 1175 0.365000959389161 1700 2253075 SGTC_1922 5578187 25 µM 0.343385105185579 0.343899631049156 no 1176 0.365654381717416 1817 1350412 SGTC_1431 4049-0260 9.09 µM 0.343194747244195 0.343975435603561 no 1177 0.365725978037745 1764 3854841 SGTC_502 l-744,832 89.3 µM 0.342940465800555 0.34407670563106 no 1178 0.365821624190457 1829 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_417 st075190 100 µM 0.339929682508967 0.345276627444258 no 1179 0.366954741428961 1838 222757 SGTC_712 r015-0009 80.6 µM 0.33873494541035 0.34575321184115 no 1180 0.367404706357669 1778 6813872 YLR060W FRS1 SGTC_893 0958-0369 48.9 µM 0.337997414670835 0.346047537301223 no 1181 0.36768256802182 1857 6819948 SGTC_1799 st045822 46.1415 µM 0.337635563285533 0.34619197490617 no 1182 0.367818919378816 1838 3674992 SGTC_1645 Cervolide 78 µM 0.336993559498283 0.3464482939794 no 1183 0.368060877606342 1713 23173 A fragrance. SGTC_3276 9139060 49.47 µM 0.335498099405506 0.347045626779693 no 1184 0.368624689090726 1752 4870619 SGTC_1754 st042065 16.137 µM 0.335320594422439 0.347116553009257 no 1185 0.368691630010287 1752 1126236 YIL048W NEO1 SGTC_1758 st042942 75.2445 µM 0.335109627975759 0.347200856507146 no 1186 0.368771195144151 1791 669317 SGTC_1914 st062367 72.6 µM 0.334688259950954 0.347369260408207 no 1187 0.368930129208868 1710 978205 SGTC_363 0455-0021 3.06 µM 0.3332292766008 0.347952590171609 no 1188 0.369480610128326 1704 4597466 SGTC_174 3553-0389 74.3 µM 0.332397725943169 0.348285221377599 no 1189 0.369794477730489 1769 738071 SGTC_647 0140-0236 81 µM 0.331314985451793 0.348718506743511 no 1190 0.370203286586078 1766 990837 SGTC_3249 9135183 49.47 µM 0.331116039368009 0.348798141419109 no 1191 0.370278418352658 1773 4902779 SGTC_3019 9081971 49.47 µM 0.330994944289982 0.348846616945593 no 1192 0.370324152197117 1843 16451803 SGTC_236 1509-0011 5.31 µM 0.33033620360164 0.349110360390821 no 1193 0.370572970159469 1813 3107280 SGTC_119 0121-0043 24.815 µM 0.330315676323167 0.349118580176217 no 1194 0.370580724544644 1742 1092378 SGTC_521 r062-0005 13.8 µM 0.329978131650768 0.349253754116467 no 1195 0.370708242966291 1695 2832033 SGTC_756 0508-1999 28.3 µM 0.329263395318654 0.349540042227855 no 1196 0.370978304607137 1645 6753853 SGTC_1622 st003707 19.4 µM 0.328476312293024 0.349855407889703 no 1197 0.371275775830648 1772 10140899 SGTC_2398 5228213 48.84 µM 0.327321897518446 0.350318142129086 no 1198 0.371712216006454 1913 80771 YMR134W ERG29 SGTC_1251 0490-5699 265 µM 0.326107423741607 0.350805190269033 no 1199 0.372171540231635 1883 3883818 SGTC_1822 st052468 42 µM 0.32575606076123 0.350946145380755 no 1200 0.372304462636134 1730 2873678 SGTC_1971 st069429 63.5 µM 0.325563454026826 0.351023421486333 no 1201 0.372377333201567 1860 1246522 YGL099W LSG1 SGTC_3068 9116768 49.47 µM 0.325452004643928 0.351068139114567 no 1202 0.372419500894105 1732 41904888 SGTC_411 enrofloxacin 100 µM 0.325275447478162 0.351138984622911 no 1203 0.372486305725074 1902 71188 A bacterial gyrase inhibitor. SGTC_2746 daunorubicin 9.88 µM 0.322513616106271 0.352247871970293 no 1204 0.373531812111834 1855 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_588 3970-1144 52.9 µM 0.32242896837614 0.352281878308738 no 1205 0.373563870725129 1815 1888707 SGTC_2061 5245884 80.95 µM 0.322346742562873 0.352314912798329 no 1206 0.373595012924259 1724 573863 SGTC_817 1391-0715 46 µM 0.320583005573989 0.353023767815019 no 1207 0.374263208991379 1699 1353946 SGTC_749 1000-0129 128 µM 0.318684910351588 0.353787192285659 no 1208 0.374982729151996 1887 708470 SGTC_389 tpck 16.7 µM 0.317767147982781 0.354156532627145 no 1209 0.375330786072838 1756 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_170 4197-0004 226 µM 0.316523456909542 0.354657257274069 no 1210 0.375802611824136 1817 218692 SGTC_778 3456-2434 196 µM 0.316433161894866 0.354693620901295 no 1211 0.375836874769385 1903 5539063 SGTC_1426 4048-4480 71.7 µM 0.316427215922122 0.354696015511156 no 1212 0.375839131036154 1829 14224343 SGTC_1500 4488-1866 171 µM 0.316197518289683 0.354788525579484 no 1213 0.375926295655791 1848 2900003 SGTC_3118 9124250 49.47 µM 0.31610705800251 0.354824960553604 no 1214 0.375960624854641 1739 1504786 SGTC_60 0986-0278 202 µM 0.315600270879042 0.355029105345834 no 1215 0.376152966025959 1585 3110598 SGTC_1123 mangostin 811.285 nM 0.315249022629728 0.355170620147991 no 1216 0.376286293504262 1719 5281650 An antioxidant. SGTC_2750 bromebric acid 70.15 µM 0.31419090512448 0.355597046966688 no 1217 0.376688024928627 1771 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1187 1391-0724 117 µM 0.313582089289124 0.355842484870756 no 1218 0.376919232273156 1778 6997986 SGTC_3214 9129694 49.47 µM 0.31323972151994 0.355980533211829 no 1219 0.377049271190827 1869 17158655 SGTC_1203 3992-3522 103 µM 0.313049932709046 0.356057067332848 no 1220 0.377121363225092 1956 5322312 SGTC_308 4092-1169 104 µM 0.312678670674461 0.356206799004784 no 1221 0.377262400967605 1767 2268590 YDL196W YDL196W SGTC_1284 0929-0043 16 µM 0.312238322732213 0.356384422085147 no 1222 0.377429704796758 1753 1239883 SGTC_218 alverine citrate 93.75 µM 0.311653639133671 0.356620313965882 no 1223 0.377651882416334 1834 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2734 clemastine 41.6 µM 0.309533416142986 0.357476182105612 no 1224 0.378457898481497 1817 26987 Clemastine is a selective histamine H1 antagonist. SGTC_919 tnp00227 403.569 nM 0.309249166055191 0.357590979657966 no 1225 0.378565998232337 1761 1269246 A methoxyflavone. YNL221C POP1 SGTC_1768 st044301 37.178 µM 0.308791833605501 0.357775705482163 no 1226 0.378739940806589 1731 3931349 SGTC_1151 3909-8316 15.3 µM 0.307356968055354 0.358355492750071 no 1227 0.379285839219479 1756 800431 SGTC_866 0495-0101 262 µM 0.30651849906697 0.358694444911961 no 1228 0.379604948510779 1689 635694 SGTC_1135 dihydrocapsaicin 536.708 nM 0.306449588308905 0.358722307128263 no 1229 0.379631178608993 1649 107982 A Capsaicinoid. SGTC_2811 7967822 32.47 µM 0.306422910936419 0.358733093610011 no 1230 0.37964133319689 1838 2232244 SGTC_1919 st067113 52.3 µM 0.3063833403671 0.358749093415079 no 1231 0.379656395658642 1737 1268243 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.305327352701696 0.359176158713991 no 1232 0.380058422743608 1867 23847180 SGTC_2656 pseudo-anisatin 100 µM 0.300982040755983 0.360935348420857 no 1233 0.381714094658993 1798 6708809 A neurotoxin. SGTC_2074 5212007 75.395 µM 0.300586098257931 0.361095791848308 no 1234 0.3818650667401 1920 758611 SGTC_1391 3442-0225 151 µM 0.297997791207692 0.362145224019522 no 1235 0.382852424722346 1790 5227075 SGTC_1787 fluconazole 80 µM 0.29792247072625 0.362175778364728 no 1236 0.382881168561169 1790 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2102 5377816 72.7585 µM 0.296153958291838 0.36289344133709 no 1237 0.383556254187875 1908 1379702 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.295755547461002 0.363055183178847 no 1238 0.383708386491991 1803 88881 An O-methylated flavonoid and antioxidant. SGTC_596 1155-0152 116 µM 0.295509146400066 0.363155226224532 no 1239 0.383802483171544 1754 280313 SGTC_351 caspofungin 25 nM 0.29387050339788 0.36382078054358 no 1240 0.384428429142371 1836 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3281 9140613 49.47 µM 0.292504816872565 0.364375784528188 no 1241 0.38495033875858 1698 16013766 SGTC_2760 etidronate 98.04 µM 0.292065073350898 0.364554553350715 no 1242 0.385118435199285 1762 3305 A chelator and antioxidant. SGTC_3195 9113082 49.47 µM 0.291616690061367 0.364736864831022 no 1243 0.385289856510167 1946 17018038 SGTC_17 0960-0276 49.807 µM 0.291345003574597 0.364847346737338 no 1244 0.38539373581568 1815 6821114 SGTC_1060 3448-7350 82 µM 0.291124183951367 0.364937151790547 no 1245 0.385478172238154 1907 570178 SGTC_2292 7671323 168.05 µM 0.290052671435514 0.365373029961449 no 1246 0.385887971363464 1778 937504 SGTC_2879 9041815 71.43 µM 0.288385365502494 0.366051615340291 no 1247 0.386525884375547 1894 4942971 SGTC_2810 7959871 45.46 µM 0.287892628668637 0.366252237170551 no 1248 0.386714464813547 1860 2974535 SGTC_1733 st037357 54.9 µM 0.287181512096388 0.366541838547169 no 1249 0.386986670787187 1674 1272339 YGL099W LSG1 SGTC_3130 9127414 49.47 µM 0.286985043419623 0.366621863588456 no 1250 0.387061886192959 1817 1494646 SGTC_2587 piperic acid 92.2 µM 0.285797745222224 0.367105593671066 no 1251 0.387516517592593 1767 5370536 SGTC_1118 chelidonine 707.474 nM 0.285563447386734 0.367201076458843 no 1252 0.387606251424963 1947 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2131 toluylene red 5.2905 µM 0.285225143271075 0.367338959145854 no 1253 0.387735829261113 1747 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_103 0844-0104 51.839 µM 0.2812382236873 0.368965193264913 no 1254 0.389263844498701 1898 5375804 SGTC_2597 laccaic acid a 100 µM 0.281124519212675 0.369011607035228 no 1255 0.389307447794496 1805 5491415 A textile dye. SGTC_491 tetrandrine 80.3 µM 0.27933607095274 0.369741896278505 no 1256 0.389993463460236 1903 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2714 st079313 56.9 µM 0.278797354492039 0.369961966279665 no 1257 0.390200172402156 1801 2939799 SGTC_2174 5790901 200 µM 0.277221887200609 0.370605801478568 no 1258 0.390804867219702 1810 786020 SGTC_1340 1486-1359 257 µM 0.27558752680228 0.371274087258028 no 1259 0.391432445489571 1839 4309068 SGTC_1209 2323-2347 50.3 µM 0.274371030950096 0.371771761495103 no 1260 0.391899751522814 1968 5412760 SGTC_675 1309-0189 238 µM 0.273832035543555 0.37199233565874 no 1261 0.392106851711403 1805 4246530 SGTC_2345 9052315 157.45 µM 0.273729965775648 0.372034110607037 no 1262 0.392146073798199 1803 6469265 SGTC_1864 st057645 30.4 µM 0.272854539696025 0.372392465382989 no 1263 0.392482516489201 1940 688666 SGTC_1088 bifonazole 369 nM 0.271901162442004 0.372782855103578 no 1264 0.392849008700523 1862 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2374 9071832 200 µM 0.27146254638311 0.372962503898899 no 1265 0.393017651083138 1900 17381698 SGTC_659 k018-0002 107 µM 0.270672250620428 0.373286263727638 no 1266 0.393321560575309 1962 6797879 YHR007C ERG11 SGTC_1007 4101-0031 70 µM 0.270130507046911 0.373508251089825 no 1267 0.393529926498577 1939 1146276 SGTC_136 0097-0015 404.482 µM 0.270098802637723 0.373521243736738 no 1268 0.393542121623381 1964 4861337 SGTC_564 3555-0129 330 µM 0.268008162415835 0.374378316632004 no 1269 0.394346517903882 1952 563260 SGTC_214 4373-3496 70 µM 0.267752729594714 0.374483075807573 no 1270 0.394444829397248 1910 3779166 SGTC_47 0149-0135 24.25 µM 0.266547721187454 0.37497740373536 no 1271 0.394908706017402 1715 5239155 SGTC_1861 st057647 17.4 µM 0.264453046931645 0.375837185876777 no 1272 0.395715420176509 1959 688668 SGTC_573 3702-0553 84.7 µM 0.264415605791066 0.375852559629304 no 1273 0.395729843820812 1839 1222756 SGTC_337 1315-0038 354 µM 0.264394587748644 0.375861189959776 no 1274 0.395737940772622 1839 1626437 SGTC_2156 5649887 115 µM 0.261385301654484 0.377097487933381 no 1275 0.396897695367554 1950 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3336 9143619 71.43 µM 0.260230580372263 0.377572214836602 no 1276 0.397342958449877 1954 45595730 SGTC_2266 7929956 200 µM 0.259833350217752 0.377735566178289 no 1277 0.397496162239918 1801 2967153 SGTC_1653 st012112 65 µM 0.258980037031362 0.378086544601585 no 1278 0.397825321649484 1919 720429 SGTC_2679 rapamycin 1 nM 0.257642946055692 0.378636709205759 no 1279 0.39834124107612 1863 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1073 triclabendazole 3.09 µM 0.257454513097586 0.378714262363225 no 1280 0.398413962648722 1852 50248 An antihelmetic and likely tubulin inhibitor. SGTC_104 0074-0074 590.992 µM 0.25584998907752 0.379374832219424 no 1281 0.399033336226259 1939 3943124 SGTC_550 4123-0385 25.7 µM 0.255097150754003 0.379684891355876 no 1282 0.39932403237731 1846 5731123 SGTC_1249 0481-0015 10.2 µM 0.255047428554874 0.379705372346217 no 1283 0.399343233754905 1808 4227577 SGTC_1379 2144-0755 36.5 µM 0.254759771032716 0.379823867511475 no 1284 0.399454324140469 1978 5392327 SGTC_2430 5571206 200 µM 0.254460549516608 0.379947138223321 no 1285 0.399569889060713 1978 1731771 SGTC_1940 st075990 51.1 µM 0.252842232116085 0.380614049838415 no 1286 0.400195065615482 1915 1084979 SGTC_462 ag-879 158 µM 0.252794239809411 0.380633832986114 no 1287 0.400213609566717 1956 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1628 st004252 77.7 µM 0.25064134194564 0.381521610069346 no 1288 0.401045707731181 1960 692968 SGTC_602 3130-1533 38.1 µM 0.25018538894807 0.381709708753853 no 1289 0.401221991983213 1955 720941 SGTC_1013 4112-3890 241 µM 0.2500400252918 0.381769682898756 no 1290 0.401278197890307 1831 705171 SGTC_1506 4226-2149 212 µM 0.249567618398059 0.381964608151184 no 1291 0.401460871528091 1877 991114 SGTC_1691 st019933 84.6 µM 0.249247611392865 0.382096666934929 no 1292 0.401584626338217 2013 6176082 SGTC_2260 7964312 200 µM 0.248490535903311 0.382409147401531 no 1293 0.401877445875908 1983 231951 SGTC_1797 st048695 56.8 µM 0.247276388607199 0.382910442612639 no 1294 0.40234716532479 1974 592262 YIL048W NEO1 SGTC_2534 helenine 20.12 µM 0.244838747418845 0.383917483628194 no 1295 0.403290645351694 1841 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3070 9117005 49.47 µM 0.242641715077831 0.384825796373536 no 1296 0.404141481372726 1946 8779016 SGTC_1078 idebenone 36.1 µM 0.241833460096874 0.385160110307751 no 1297 0.404454605440913 1900 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1272 0839-0021 27 µM 0.241502205044524 0.385297150139457 no 1298 0.404582953838355 1901 5027250 SGTC_2376 9072922 81.32 µM 0.241060231770515 0.3854800162747 no 1299 0.404754217210594 1922 17087968 SGTC_638 3970-0837 4.09 µM 0.239836338694565 0.385986533945206 no 1300 0.405228567389055 1846 4118451 YLR208W SEC13 SGTC_2694 st077685 81.9 µM 0.238193690266304 0.386666662233866 no 1301 0.405865435371876 1830 2838096 SGTC_1497 4476-2978 41.3 µM 0.237973729322796 0.386757762168209 no 1302 0.405950734952631 1936 1528379 SGTC_1828 st055811 49 µM 0.235915094868954 0.387610676589849 no 1303 0.406749277402621 2009 5877589 SGTC_3121 9125696 49.47 µM 0.235236369646663 0.387891998909795 no 1304 0.407012639492136 2043 1235365 SGTC_147 4466-0538 29.23 µM 0.234848209819611 0.388052912310563 no 1305 0.40716327396642 1901 6742687 YHR072W ERG7 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.232451155244371 0.389047046952706 no 1306 0.408093810330714 1866 61125 An anti-inflammatory. SGTC_114 0364-0001 490.298 µM 0.2302718449524 0.389951507163174 no 1307 0.408940268626341 1847 4003655 SGTC_1640 st009078 66.4 µM 0.229213997437494 0.390390751655977 no 1308 0.409351296895666 1981 690618 SGTC_98 0074-0023 107.663 µM 0.228276842130233 0.390779998681561 no 1309 0.409715513302979 1840 3563821 SGTC_1665 st014639 11.4 µM 0.228085097607255 0.390859653183042 no 1310 0.409790042582682 1948 981133 YIL048W NEO1 SGTC_2899 9053889 58.44 µM 0.226761021949005 0.391409825461524 no 1311 0.410304787078034 2047 6470052 SGTC_1717 st033143 58.0435 µM 0.225905610929593 0.39176537653234 no 1312 0.410637416868331 2002 674616 SGTC_568 1193-0097 7.48 µM 0.225042972727375 0.392124023149818 no 1313 0.410972922076452 1984 3646150 SGTC_44 0929-0055 61.211 µM 0.224043369398179 0.392539728416633 no 1314 0.41136177848233 1875 1379590 SGTC_519 k048-0011 62.8 µM 0.221963025640596 0.393405274144468 no 1315 0.412171333316783 1925 6836379 SGTC_173 1273-0061 2.693 µM 0.220822023629803 0.393880222390541 no 1316 0.412615507238982 1844 2847414 YPL266W DIM1 SGTC_1395 3486-0190 4.35 µM 0.219543411671446 0.394412639097521 no 1317 0.413113383487099 2033 6748079 SGTC_637 1181-0519 7.26 µM 0.219044246131064 0.394620546286853 no 1318 0.413307790574698 1949 6252091 YGR060W ERG25 SGTC_397 arbidol 50 µM 0.217517473189358 0.395256647809524 no 1319 0.41390254566385 2006 131410 A RNA synthesis inhibitor. SGTC_3149 9097855 49.47 µM 0.216562758066696 0.395654554088241 no 1320 0.41427455584397 2009 25236625 YMR079W SEC14 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.216176480451033 0.395815577851918 no 1321 0.41442509299092 1934 2346 DNA damaging agent; causes G2/M arrest. SGTC_1980 st071811 45.7 µM 0.215830978331946 0.395959619000756 no 1322 0.414559750075557 1986 4974850 SGTC_2558 carylophyllene oxide 100 µM 0.215686296834639 0.396019941489413 no 1323 0.414616141682099 2044 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2693 st077581 40.7 µM 0.215132694669595 0.396250779473442 no 1324 0.414831931991063 2055 25238761 SGTC_2155 5570423 76 µM 0.214798574811949 0.396390116541913 no 1325 0.414962182050131 1901 797402 SGTC_2576 guaiol 23.12 µM 0.214162414409612 0.396655449307064 no 1326 0.415210202510909 2065 227829 SGTC_758 0868-0029 16 µM 0.213731880184488 0.396835045704697 no 1327 0.415378074478315 2046 762687 SGTC_741 4582-0002 126 µM 0.213539113831115 0.396915464856815 no 1328 0.415453242075814 1883 2912688 SGTC_1299 1079-1439 3.74 µM 0.212659549396557 0.39728246117382 no 1329 0.415796259963902 1904 323161 SGTC_1898 st060199 18.6 µM 0.211072291244985 0.397944971109022 no 1330 0.416415430759314 1874 688866 SGTC_788 1182-0090 188 µM 0.210376697301818 0.39823539981683 no 1331 0.416686839272988 2030 5715185 SGTC_299 1273-0059 1.44 µM 0.209853090802009 0.398454056464148 no 1332 0.416891167522961 2029 2848077 SGTC_138 0850-0259 40.9225 µM 0.209322298167322 0.398675746565826 no 1333 0.417098322952992 2034 6813004 SGTC_463 ikarugamyin 104 µM 0.20895874213838 0.398827607734859 no 1334 0.417240223296571 2029 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1950 st077106 7.18 µM 0.207298488647434 0.399521307409288 no 1335 0.417888377198887 1891 13831864 SGTC_994 3910-0338 138 µM 0.206844306067018 0.399711132781999 no 1336 0.418065726537772 2009 3479481 SGTC_127 0180-0333 59.125 µM 0.206599104165007 0.399813624645962 no 1337 0.418161479971971 2066 771601 SGTC_2153 5569715 200 µM 0.205342459484939 0.400338997345483 no 1338 0.418652286453088 1965 2054701 SGTC_499 genistein 192 µM 0.204902486250066 0.400522982179905 no 1339 0.418824156343567 2054 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2686 alizarin 95.37 µM 0.204367504013895 0.400746726928529 no 1340 0.419033161151817 1899 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_447 ml7 120 µM 0.203098605427546 0.401277546414647 no 1341 0.41952898086146 2072 4216 Selective myosin light chain kinase inhibitor. SGTC_2194 5927483 104.545 µM 0.20288474201545 0.401367030062883 no 1342 0.41961256018849 2019 760979 SGTC_1790 st045711 43.5 µM 0.202310139968383 0.401607477757298 no 1343 0.419837136664868 2067 585119 SGTC_1654 st012436 41.8 µM 0.201488171006002 0.401951503238152 no 1344 0.420158438970158 2053 4323132 SGTC_1112 tnp00069 1.16933 µM 0.20055343495255 0.402342818387088 no 1345 0.420523885853973 2037 145826 SGTC_2185 6113692 200 µM 0.200516616948756 0.402358233774034 no 1346 0.420538281722787 1951 874150 SGTC_3243 9134147 49.47 µM 0.200494963556303 0.402367299937321 no 1347 0.42054674826612 2070 24282180 SGTC_1221 2958-7315 257 µM 0.200264347549388 0.402463860922411 no 1348 0.420636922116786 1980 4562705 SGTC_2466 5983409 37.09 µM 0.199853183326215 0.402636033821328 no 1349 0.420797702991234 1936 2879657 SGTC_1997 st073024 93.8 µM 0.198622233086448 0.403151600667652 no 1350 0.421279130312128 2071 686268 SGTC_1150 3909-7983 10.9 µM 0.198111711905623 0.403365475010782 no 1351 0.421478830834374 1924 23965914 SGTC_1476 4112-3294 3.34 µM 0.196800247654604 0.403915023470306 no 1352 0.421991928653114 2035 704369 SGTC_2680 butyl paraben 22.24 µM 0.196554477982294 0.404018030523926 no 1353 0.422088098443372 2057 7184 An antifungal and steroid mimetic. SGTC_358 0075-0058 9.45 µM 0.195776007595336 0.404344347147147 no 1354 0.422392744914492 2168 1069125 SGTC_3099 9120367 49.47 µM 0.195628670861637 0.404406114765782 no 1355 0.422450408878377 1966 24824940 SGTC_2677 mitomycin C 100 µM 0.195547137993519 0.404440296614953 no 1356 0.422482319546605 1960 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1905 st060207 84.5 µM 0.194887979043079 0.404716669254793 no 1357 0.422740322545035 1936 1948547 SGTC_1526 st051518 75 µM 0.194335659990498 0.40494828259899 no 1358 0.422956532607719 1912 673993 SGTC_3329 9141233 27.5565 µM 0.192507155500488 0.405715297683246 no 1359 0.423672481729426 2044 4909101 YNL103W MET4 SGTC_1271 0832-2808 169 µM 0.192349625992996 0.405781394630661 no 1360 0.423734174077989 2081 3663794 SGTC_1032 k061-1018 98.7 µM 0.190630917855477 0.406502712152819 no 1361 0.424407382714228 2107 4005393 SGTC_3000 9075062 71.4286 µM 0.190594188054106 0.406518130603902 no 1362 0.42442177199223 1940 17057871 SGTC_1525 8-methoxypsoralen 92.5 µM 0.190120726608181 0.406716893411188 no 1363 0.424607264401851 2090 4114 Related to psoralen; DNA damaging agent. SGTC_1930 st074634 34.3 µM 0.189273944856164 0.407072438891744 no 1364 0.424939057603448 1882 684253 YOR116C RPO31 SGTC_627 1391-0720 175 µM 0.188098011973391 0.407566314845226 no 1365 0.425399909749135 1987 997839 SGTC_1416 3966-0321 25.3 µM 0.187683607021254 0.407740394395152 no 1366 0.425562340802176 1986 582530 YLR208W SEC13 SGTC_401 neomycin 50 µM 0.187511523515409 0.407812687060148 no 1367 0.425629794735827 1993 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.186979383362126 0.408036260177724 no 1368 0.425838398779284 1960 115019 SGTC_1226 3909-7979 35.4 µM 0.186278481227758 0.408330782562579 no 1369 0.426113190803656 2064 6615510 SGTC_395 anisomycin 6.25 µM 0.185219558785488 0.408775844950875 no 1370 0.426528414407108 1960 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_877 0771-0151 33.1 µM 0.184037033800896 0.409272996211816 no 1371 0.426992201156792 1996 6166523 SGTC_1207 2099-0101 141 µM 0.183995646791177 0.409290398580369 no 1372 0.427008434989717 2087 5837381 SGTC_768 0384-0033 77.3 µM 0.181690217220087 0.41026006467656 no 1373 0.427912921858262 1904 3965305 YMR134W ERG29 SGTC_1636 st007707 68.9 µM 0.181557914585788 0.410315728013783 no 1374 0.427964839559582 2067 403051 SGTC_1125 tnp00248 1.32998 µM 0.180952389962263 0.410570511828755 no 1375 0.428202473153373 2098 24207736 SGTC_2943 9068529 45.32 µM 0.180477154400747 0.410770500954864 no 1376 0.428388994024684 2059 3270634 SGTC_703 3875-0075 71.8 µM 0.179682147667735 0.411105108360282 no 1377 0.428701054713638 2012 2850814 SGTC_1796 st049173 110.4 µM 0.178814308963047 0.411470443580998 no 1378 0.429041754720922 2086 94134 SGTC_2799 7812892 81.82 µM 0.174989974643008 0.413081289211027 no 1379 0.430543755558131 2073 20205235 SGTC_142 0335-0849 62.6745 µM 0.174909449405094 0.413115223036835 no 1380 0.430575392592733 2034 3889043 YPR107C YTH1 SGTC_1941 st076221 61.8 µM 0.173596018386121 0.413668802336617 no 1381 0.431091480689072 2125 2828568 SGTC_168 3970-0862 530.542 µM 0.173143456820195 0.413859585865952 no 1382 0.431269333577085 2014 3135186 SGTC_2255 7941087 197.44 µM 0.171559981703822 0.414527281252842 no 1383 0.431891735435903 2115 935561 SGTC_1829 berberine 14.4 µM 0.170357309817683 0.415034570587831 no 1384 0.432364571580641 2103 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_83 0170-0301 39.027 µM 0.170317071483134 0.415051545649807 no 1385 0.432380393151045 2117 3089716 SGTC_2412 st077135 33.4 µM 0.17020577733353 0.415098497352433 no 1386 0.432424154180492 2067 13258915 SGTC_958 1222-0007 33 µM 0.167583477648874 0.416205117319712 no 1387 0.433455485144223 2062 7312461 SGTC_3035 9091303 49.47 µM 0.167164392055487 0.416382034780781 no 1388 0.433620350583536 2076 25237002 SGTC_1424 4048-1941 275 µM 0.166628248745751 0.416608392986588 no 1389 0.433831282573382 2104 X1424 SGTC_660 4031-1742 102 µM 0.166374130502178 0.416715690663056 no 1390 0.433931265538802 1996 6738706 SGTC_620 0109-0052 432 µM 0.165014876040086 0.417289720960914 no 1391 0.434466136592383 2113 493037 SGTC_2407 paclitaxel 400 µM 0.164926404163274 0.417327089875361 no 1392 0.434500954733095 2027 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2868 9035608 32.47 µM 0.164435954644397 0.417534260382568 no 1393 0.434693980534817 2086 6462614 SGTC_1170 0310-0127 64.8 µM 0.164254989544887 0.417610707533936 no 1394 0.434765206749945 2039 774975 SGTC_2141 5621638 7.665 µM 0.163830742489075 0.41778993925965 no 1395 0.434932194823311 2100 2856238 SGTC_1726 st035556 14.5795 µM 0.162370570309324 0.418406948766305 no 1396 0.435507022387438 2085 5919439 SGTC_1939 st074455 53.6 µM 0.162147772799856 0.418501111648517 no 1397 0.435594743339338 2129 1644229 SGTC_2341 7987486 176.74 µM 0.161884374332647 0.418612440096883 no 1398 0.435698453991404 2126 1258686 SGTC_608 k048-0125 159 µM 0.160980502971631 0.41899452143359 no 1399 0.43605437836267 2115 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2303 7774051 200 µM 0.157141490422225 0.420618182692661 no 1400 0.437566669564252 2104 2953184 SGTC_1707 st032323 6.317 µM 0.157088522268266 0.42064059441103 no 1401 0.437587541589726 2057 3132057 YMR211W DML1 SGTC_2844 9010103 25.97 µM 0.156536364260097 0.420874237071481 no 1402 0.437805128995455 2005 2480525 SGTC_2670 beta-carotene 100 µM 0.156162708564399 0.421032363266815 no 1403 0.437952385154092 2112 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2244 6635614 200 µM 0.155951822346432 0.421121613177184 no 1404 0.438035498331868 1986 836499 SGTC_657 3534-0529 86.7 µM 0.154872870620679 0.421578303521926 no 1405 0.438460770834108 2120 1049549 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.154589902207282 0.421698093692536 no 1406 0.438572315582421 2102 4620898 SGTC_1451 4152-0210 104 µM 0.152690430473887 0.422502391841432 no 1407 0.439321203823165 2131 659563 SGTC_849 0386-0493 241 µM 0.152651161088381 0.422519023198973 no 1408 0.43933668852412 2033 726119 SGTC_2186 6124449 200 µM 0.152418668944112 0.422617491026028 no 1409 0.439428366708676 2099 3834182 YLR033W RSC58 SGTC_1534 6-azauridine 81.6 µM 0.152233676256349 0.422695844775545 no 1410 0.439501316844196 2096 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2330 7979373 200 µM 0.152171516045411 0.422722173452034 no 1411 0.439525829603036 1946 1863007 SGTC_820 1582-0060 59.9 µM 0.150398698513497 0.423473215707861 no 1412 0.44022503401399 2017 3848840 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.148717689317064 0.424185620927297 no 1413 0.440888201203238 2123 66535 A nucleotide analog. SGTC_2794 7785382 27.27 µM 0.148434818150298 0.424305525057948 no 1414 0.440999811751597 2188 2205081 SGTC_700 3453-2283 142 µM 0.148115759192759 0.424440776966382 no 1415 0.441125706293518 2116 565664 SGTC_3256 9138902 49.47 µM 0.147386595302196 0.424749909354694 no 1416 0.441413442687484 2149 17228773 SGTC_1765 st044815 90.4 µM 0.146422678566254 0.42515863730099 no 1417 0.44179386267021 1977 645695 SGTC_2715 st079500 56.4 µM 0.14112170705675 0.427407825515094 no 1418 0.443886897754238 2058 28246688 SGTC_324 1315-0088 19.6 µM 0.13878818695706 0.428398684882529 no 1419 0.444808764540477 2119 6787421 SGTC_540 1187-0821 17.3 µM 0.138421256358565 0.428554532207192 no 1420 0.444953749288685 1972 847520 SGTC_2572 astragaloside iv 100 µM 0.137620214895918 0.428894799174277 no 1421 0.445270289184944 2031 45006101 An anti-inflammatory agent. SGTC_430 0958-0115 16.4 µM 0.137426637601399 0.428977035015271 no 1422 0.445346788516768 2001 6833180 SGTC_2703 st077852 53.4 µM 0.136896393510292 0.429202310005615 no 1423 0.445556344780319 2073 6281836 SGTC_1889 st059080 5.18 µM 0.136706089109523 0.429283166740468 no 1424 0.445631558155378 2211 176925 Isolated from Daphnopsis sellowiana. SGTC_375 3970-0961 9.27 µM 0.135757242673941 0.429686357828795 no 1425 0.446006596722001 2099 2898222 SGTC_2764 methyldopa 94.69 µM 0.135032145491131 0.429994521138876 no 1426 0.446293229327308 2147 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1385 3091-4834 14.1 µM 0.13349131333119 0.430649509835994 no 1427 0.44690241687277 2107 4072814 SGTC_2233 sulbentine 40.3845 µM 0.132498186509001 0.431071777017517 no 1428 0.447295128667763 2125 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_526 4469-0568 170 µM 0.132468624588857 0.431084347648224 no 1429 0.447306819121535 2016 2901964 SGTC_906 1165-0455 526 µM 0.132275436451348 0.431166498858895 no 1430 0.447383217754881 2158 3252859 SGTC_1750 st081859 2.357 µM 0.131953934193008 0.431303220891424 no 1431 0.447510364117641 2089 5291695 SGTC_2780 5215298 71.43 µM 0.131313396481501 0.431575640444475 no 1432 0.447763697347689 2210 2834131 SGTC_2168 5727979 200 µM 0.128683634925746 0.43269441310852 no 1433 0.448803992585461 2170 695210 SGTC_3057 9095946 49.47 µM 0.126525715951583 0.433612854611835 no 1434 0.449657897116954 2197 24540043 SGTC_2992 9074591 71.4286 µM 0.126266975807953 0.433723002329479 no 1435 0.449760298241816 2207 17741321 SGTC_2635 hydroquinidine 100 µM 0.124881019039626 0.434313102467693 no 1436 0.450308872668152 2095 442912 An experimental heart treatment. SGTC_391 gliotoxin 8.33 µM 0.123959719699874 0.434705446051442 no 1437 0.450673584017599 2120 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_336 4111-0029 111 µM 0.122049595175482 0.435519094161766 no 1438 0.451429870280492 2075 3131175 SGTC_2431 5490079 200 µM 0.121159492045408 0.435898341309863 no 1439 0.451782354175843 2090 5722345 SGTC_2616 abietic acid 100 µM 0.121029201822341 0.435953859152364 no 1440 0.451833952747599 2222 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1396 3511-0007 98.6 µM 0.117680053628508 0.437381391623759 no 1441 0.453160585922837 2099 X1396 SGTC_2319 6033012 152.6 µM 0.117520206834977 0.437449544855658 no 1442 0.453223916127771 2109 847246 SGTC_1704 st028805 70.8 µM 0.115374279306416 0.438364674219184 no 1443 0.454074232471601 2087 2876101 SGTC_787 4152-0075 138 µM 0.115277729137971 0.438405855760431 no 1444 0.454112495119755 2060 9566539 SGTC_325 2810-4341 181 µM 0.114698911184534 0.438652752938228 no 1445 0.454341888491129 2208 774970 SGTC_3246 9135460 32.98 µM 0.114512495803711 0.438732274272767 no 1446 0.454415770669912 2167 41446951 SGTC_1432 4049-0298 68.4 µM 0.114447267531785 0.438760100024748 no 1447 0.454441623023337 2231 741646 SGTC_2787 5284540 71.43 µM 0.113662434142176 0.439094926074496 no 1448 0.454752696343232 2100 736958 SGTC_179 1273-0063 6.77 µM 0.112740582956768 0.439488262375293 no 1449 0.455118112897522 2117 3108139 SGTC_2019 4016004 108 µM 0.111719428179782 0.439924039355655 no 1450 0.455522937153478 2110 45595336 SGTC_2828 7998861 71.43 µM 0.111400873399955 0.440059997272561 no 1451 0.455649233750123 2215 2988188 SGTC_1375 2910-0797 186 µM 0.110742576763426 0.440340978044613 no 1452 0.455910241116355 2132 742508 SGTC_724 3910-0327 137 µM 0.11025142456335 0.440550636130622 no 1453 0.456104989955277 2107 2885483 SGTC_2641 levomentholum 100 µM 0.109915080239964 0.440694221013694 no 1454 0.456238361354002 2200 16666 SGTC_18 0111-0177 500 nM 0.108682252279917 0.441220579935311 no 1455 0.456727259544724 2181 721752 SGTC_3136 9095672 49.47 µM 0.108605607019316 0.4412533072555 no 1456 0.456757656653156 2234 17217380 SGTC_1877 wortmannin 25 µM 0.108253475845812 0.441403671471575 no 1457 0.456897313278973 2218 312145 A covalent inhibitor of PI 3-kinase. SGTC_977 1348-1378 135 µM 0.107715097769973 0.441633581659996 no 1458 0.457110846454249 2219 X977 SGTC_2557 derrustone 83.84 µM 0.106948529367564 0.441960972678922 no 1459 0.457414906535556 2037 629853 An antioxidant. SGTC_2954 9074818 52.69 µM 0.106876363925545 0.44199179561078 no 1460 0.457443532312964 2163 16648742 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.106222740592516 0.442270983816186 no 1461 0.457702814316941 2190 5282309 SGTC_2950 9072895 21.46 µM 0.104631541138217 0.44295076722306 no 1462 0.458334092929284 2100 17332245 SGTC_961 1252-1571 372 µM 0.103841403875874 0.443288387819628 no 1463 0.458647604259398 2219 6813498 SGTC_3322 9139058 2.11 µM 0.103495577655877 0.443436170119984 no 1464 0.458784829583796 2174 4908926 YPR165W RHO1 SGTC_552 k242-0005 476 µM 0.102855548747181 0.443709695119359 no 1465 0.45903880873878 2124 4088318 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.101182535246249 0.444424806389635 no 1466 0.459702780207506 2197 368090 SGTC_3133 9127736 49.47 µM 0.099757460798147 0.44503408163733 no 1467 0.460268440443617 2255 27243420 SGTC_1296 1068-0102 11.9 µM 0.09959531557702 0.445103413337901 no 1468 0.460332806481692 2193 767053 SGTC_359 0081-0058 15.9 µM 0.0993058018055537 0.445227210751516 no 1469 0.46044773600759 2210 3494159 SGTC_2058 5236698 133 µM 0.0988634072930671 0.445416390983098 no 1470 0.460623361637272 2171 766665 SGTC_1449 4112-4002 201 µM 0.0972198330722933 0.446119337694153 no 1471 0.461275909068409 2068 2059539 SGTC_1994 st072947 40.9 µM 0.0956498523558825 0.446790967118723 no 1472 0.461899335110863 2148 5286565 YDL195W SEC31 SGTC_3352 9151559 45.5865 µM 0.0954658328480013 0.446869699719877 no 1473 0.461972413858014 2153 17159339 SGTC_2414 st077232 92.9 µM 0.0952003891103044 0.446983273301735 no 1474 0.462077830463431 1990 729801 SGTC_2207 7258803 200 µM 0.0950760690940913 0.447036466745579 no 1475 0.462127203025287 2214 3666799 SGTC_2424 5537928 59.2 µM 0.0949518255062153 0.447089628439583 no 1476 0.462176545817367 2149 5382802 SGTC_942 3253-1115 227 µM 0.0947483958357034 0.447176674548445 no 1477 0.46225733826886 2209 46497897 SGTC_287 k060-0039 29.6 µM 0.0929212332709079 0.447958617985357 no 1478 0.462983068507905 2241 5861974 SGTC_964 1287-0107 19.4 µM 0.0926865145587524 0.448059081766858 no 1479 0.463076305356306 2221 51516812 YPR165W RHO1 SGTC_777 1315-0167 517 µM 0.0915598166390653 0.448541374773907 no 1480 0.463523889483745 2060 4221767 SGTC_2366 9070441 60.58 µM 0.0913126596027959 0.448647182726026 no 1481 0.463622079552797 2220 6837235 SGTC_97 0535-0701 19.132 µM 0.0895668379427641 0.449394672752807 no 1482 0.464315718971521 2241 2832013 YGL099W LSG1 SGTC_2966 9084041 48.03 µM 0.0885513789688987 0.449829533894314 no 1483 0.464719225086339 2203 17741380 SGTC_2922 7999257 32.47 µM 0.0875613316043968 0.450253570759443 no 1484 0.465112668498213 2259 2988377 SGTC_8 0354-0001 70 µM 0.0870848170542984 0.450457682015361 no 1485 0.465302046884168 2188 4993152 SGTC_1820 st053765 18.6 µM 0.0867659707043355 0.450594264659964 no 1486 0.465428768512235 2153 3690829 SGTC_282 k297-0036 65.7 µM 0.0865068686269504 0.450705259253947 no 1487 0.465531748083842 2216 5061378 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.0864826867475541 0.450715618525897 no 1488 0.465541359238436 2119 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3339 9145883 14.936 µM 0.0864768690418063 0.450718110777063 no 1489 0.465543671504615 2248 2030670 SGTC_2906 7926292 26.41 µM 0.085918129530975 0.450957478639916 no 1490 0.465765749760253 2156 2966319 SGTC_1082 camptothecin 424.86 nM 0.084397659871782 0.451608948396745 no 1491 0.466370133900812 2262 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2778 tioconazole 65.09 nM 0.0840280013853672 0.451767354302891 no 1492 0.466517084303098 2242 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1854 st056233 32.9 µM 0.0825854161889066 0.452385603562875 no 1493 0.46709059892671 2265 5393174 SGTC_3307 9126885 69.2785 µM 0.0820959415185236 0.452595404210501 no 1494 0.467285210215426 2205 24824909 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.081611965356604 0.452802861078551 no 1495 0.467477643029599 2177 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_100 0086-0128 49.5915 µM 0.0813672859119127 0.452907748075185 no 1496 0.467574932440085 2178 93297 SGTC_803 4488-1585 147 µM 0.081352890939373 0.452913918885717 no 1497 0.467580656227669 2240 747204 SGTC_150 3970-0969 77.2 µM 0.081035143738275 0.45305013306856 no 1498 0.467707001868174 2152 6615640 SGTC_1934 st074720 32.6 µM 0.0800729982427603 0.453462626228804 no 1499 0.468089599027096 2246 17250992 SGTC_3046 9092212 49.47 µM 0.0797584503146755 0.453597490830208 no 1500 0.468214685422311 2259 25236637 SGTC_2771 fluoxetine 41.05 µM 0.0796787423442321 0.453631667024722 no 1501 0.468246383420352 2223 3386 A selective serotonin reuptake inhibitor. SGTC_698 k064-0052 127 µM 0.0795869362459607 0.453671030929871 no 1502 0.468282892810699 2278 5088751 SGTC_196 k015-0023 18.111 µM 0.0790640739537053 0.453895228425376 no 1503 0.468490829428981 2167 5211998 SGTC_2838 9002687 71.43 µM 0.0780291280557553 0.454339044891883 no 1504 0.468902441392735 2174 6457060 SGTC_2165 5727197 32.143 µM 0.0772841980354779 0.454658528997139 no 1505 0.469198730723766 2164 1361712 SGTC_2029 5175081 200 µM 0.0763407946295976 0.455063176045322 no 1506 0.469573985549768 2258 1380876 SGTC_2515 chrysin 20.77 µM 0.0761488938181255 0.455145492362562 no 1507 0.469650320695572 2244 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.0757016434371852 0.455337348964254 no 1508 0.469828234236903 2122 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1462 k081-0014 26.5 µM 0.0739193371661363 0.456102006345684 no 1509 0.470537284553904 2258 3270634 SGTC_1023 4482-3888 16 µM 0.0738756774629078 0.456120739585991 no 1510 0.470554654762682 2273 3303168 SGTC_2712 st079126 47.7 µM 0.0730317241793548 0.456482877051908 no 1511 0.470890436331588 2265 3152970 SGTC_33 0986-0033 35.816 µM 0.0726775142992803 0.456634878086087 no 1512 0.471031371104917 2281 2848082 SGTC_234 nsc-17383 10.7 µM 0.071853173566894 0.456988649507255 no 1513 0.471359377876512 2261 408974 SGTC_1547 harmine 94.2 µM 0.0717234545390833 0.457044322420029 no 1514 0.47141099510344 2274 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3172 9105863 49.47 µM 0.0712192194053466 0.457260738443032 no 1515 0.471611642691242 2276 2348785 SGTC_3060 1327-0027 12.5 µM 0.0710686172128912 0.457325378858437 no 1516 0.471671572415338 2287 16000455 YPR107C YTH1 SGTC_3204 9114183 49.47 µM 0.0705803905157312 0.457534939846523 no 1517 0.471865858792802 2239 17027248 SGTC_2931 9014674 55.67 µM 0.068898967854617 0.458256744969095 no 1518 0.472535020050702 2259 2996810 SGTC_3141 9094609 49.47 µM 0.0687395949406499 0.458325168133411 no 1519 0.472598450260677 2168 25236309 YDL196W YDL196W SGTC_2240 6690706 185.951 µM 0.0680882386712537 0.458604826065404 no 1520 0.472857696404988 2254 805876 SGTC_2506 ethyl hematommate 54.16 µM 0.0679339422391773 0.458671075799545 no 1521 0.472919109577454 2101 3940691 An allergen. SGTC_2136 5328288 199.296 µM 0.0673801603733099 0.458908860676191 no 1522 0.47313953150918 2224 262395 SGTC_575 k072-0246 11.9 µM 0.0670576606876513 0.459047343546868 no 1523 0.47326789993203 2277 6796779 SGTC_671 0560-0003 407 µM 0.0657314097305523 0.459616893960089 no 1524 0.473795832565933 2247 3238678 SGTC_1047 2043-3044 82 µM 0.0648420939180725 0.459998851726398 no 1525 0.474149862925542 2257 669592 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0644149088055439 0.460182339258775 no 1526 0.474319929585181 2244 688761 SGTC_2092 5303694 80.6725 µM 0.0638202924563747 0.460437757132947 no 1527 0.474556660076121 2243 1963699 SGTC_3020 9089140 49.47 µM 0.0634107719661952 0.460613676449227 no 1528 0.47471970486329 2236 17217859 SGTC_1153 4055-0057 267 µM 0.0622010418669757 0.461133389824073 no 1529 0.475201366404291 2230 882706 SGTC_1111 tnp00062 510.699 nM 0.0620878508206128 0.461182021354466 no 1530 0.47524643598651 2286 676306 SGTC_2625 euphol 100 µM 0.0606699578768145 0.461791255442775 no 1531 0.475811028866266 2304 6708538 A triterpene alcohol. SGTC_2267 7931562 200 µM 0.060491091823103 0.461868116231354 no 1532 0.47588225527707 2250 934880 SGTC_1418 3966-3099 2.4 µM 0.0579332763967838 0.462967393176643 no 1533 0.476900888446686 2286 740335 SGTC_842 0271-0008 11.1 µM 0.057375244502661 0.463207257427417 no 1534 0.477123141267338 2279 1221709 SGTC_1996 st072960 66.8 µM 0.0561575046307953 0.463730736672822 no 1535 0.477608167050232 2318 1719405 SGTC_972 1319-0219 195 µM 0.0557809596267262 0.463892617736407 no 1536 0.477758151670344 2229 23903702 SGTC_3122 9126309 49.47 µM 0.0557337263355632 0.463912924298507 no 1537 0.477776965759103 2315 17591206 SGTC_1048 3161-0300 24.5 µM 0.0542772048606685 0.464539158690001 no 1538 0.478357155331162 2303 2165101 SGTC_87 0100-0052 35.5 µM 0.0526677490209087 0.465231249636294 no 1539 0.478998317949435 2307 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1096 rimcazole 32.2 µM 0.0521109113478233 0.46547072306049 no 1540 0.479220159391038 2290 18528119 A dopamine reuptake inhibitor. SGTC_1401 3807-4679 7.6 µM 0.051741345332736 0.465629665406903 no 1541 0.479367396266083 2307 3291456 SGTC_2018 5133068 143 µM 0.0514532872646065 0.465753556752668 no 1542 0.4794821619372 2312 785362 SGTC_1776 st049249 45.9 µM 0.0511839677456352 0.465869391809009 no 1543 0.479589463492092 2266 1822314 SGTC_715 0868-0130 184 µM 0.0506286456451679 0.466108246469431 no 1544 0.479810718083224 2309 2876258 SGTC_2589 lobaric acid 100 µM 0.0504066032828727 0.466203754559233 no 1545 0.4798991872094 2270 73157 A novel microtubule depolymerizer. SGTC_2958 9077254 16.72 µM 0.0496934428124305 0.466510522648946 no 1546 0.480183340941545 2260 16457351 SGTC_1274 0865-0114 173 µM 0.0474463748782572 0.467477234841443 no 1547 0.481078734403429 2258 870624 SGTC_1308 1187-1617 41.4 µM 0.0473329415161015 0.467526040198147 no 1548 0.481123936981553 2310 2882570 SGTC_1071 trifluoperazine 6.31 µM 0.0460956991830724 0.468058402374603 no 1549 0.481616986960618 2292 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_911 3456-4043 236 µM 0.0455549992777822 0.468291073399827 no 1550 0.481832468640666 2298 914281 SGTC_2927 9011802 47.9 µM 0.0429864588833554 0.469396500242872 no 1551 0.482856164061081 2260 43912568 SGTC_1159 4092-0538 61.2 µM 0.0413971320900472 0.470080620066414 no 1552 0.483489649549846 2348 717301 SGTC_1855 st056195 39.6 µM 0.0401661597752548 0.470610548335293 no 1553 0.483980328217256 2345 4028379 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.0389586330784479 0.471130433945152 no 1554 0.48446168478905 2197 688788 SGTC_1196 1588-0294 184 µM 0.0388636243218714 0.471171340883827 no 1555 0.484499559115883 2260 6144269 SGTC_2808 7946468 45.46 µM 0.0383131969956762 0.471408338662712 no 1556 0.484718984415676 2309 2970879 SGTC_458 nppb 133 µM 0.0378543079513423 0.47160593049936 no 1557 0.484901921944002 2341 4549 A chloride channel blocker. SGTC_1564 D-Arginine 115 µM 0.0351594312413193 0.472766449887081 no 1558 0.485976305697318 2287 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2278 7948257 134.34 µM 0.0342588632007219 0.473154321764495 no 1559 0.486335364004569 2359 1247028 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.0338079940992239 0.473348519280948 no 1560 0.486515130610892 2345 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_949 1165-0505 146 µM 0.0334947422773024 0.473483446265932 no 1561 0.486640029268004 2314 6244267 SGTC_505 gw-5074 63.9 µM 0.0322885608287591 0.47400301318049 no 1562 0.487120965792978 2325 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2772 vinpocetine 57.06 µM 0.0321288735486046 0.474071802373883 no 1563 0.487184638764822 2332 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_396 dithiazanine 1.25 µM 0.0320241045690839 0.474116934589011 no 1564 0.487226414043563 2319 10578 An antihelmenthic. SGTC_3208 9114115 49.47 µM 0.0320107265867276 0.474122697559 no 1565 0.487231748351511 2267 650895 SGTC_2923 7992654 58.14 µM 0.0319506993708446 0.474148556162038 no 1566 0.487255683502738 2335 2985126 SGTC_237 nikkomycin 200 µM 0.0318366831959164 0.474197672499711 no 1567 0.487301146247138 2341 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_950 1165-0508 94.1 µM 0.031786748373202 0.474219183743194 no 1568 0.487321057281795 2306 6148369 SGTC_2742 clothiapine 36.27 µM 0.0305597528017467 0.474747780232975 no 1569 0.487810319878937 2350 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1020 4335-0961 93.3 µM 0.0304109418310008 0.474811891864826 no 1570 0.487869659286764 2320 669075 SGTC_974 1326-0144 138 µM 0.0294098890833602 0.475243188262318 no 1571 0.488268842934684 2321 5411856 SGTC_1199 1638-0010 4.46 µM 0.0286061114233505 0.475589511126068 no 1572 0.488589368934749 2337 3111136 SGTC_1232 0279-0259 161 µM 0.0276142805299322 0.476016885687324 no 1573 0.488984895896698 2346 1560000 SGTC_1632 st005650 90 µM 0.0271151328852377 0.476231976172234 no 1574 0.489183952450831 2335 2759605 SGTC_1677 st019204 53.9 µM 0.0269061228288766 0.476322043917664 no 1575 0.489267304987722 2243 3945625 SGTC_2790 5423970 71.43 µM 0.0265541140534554 0.476473736177552 no 1576 0.489407686010559 2337 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2175 5807670 165.306 µM 0.0264851228882032 0.476503467159852 no 1577 0.489435199826548 2355 241186 SGTC_2040 5100729 123 µM 0.0230963563469642 0.477963976493055 no 1578 0.490786706063087 2350 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1172 0370-0043 85 µM 0.021832015806667 0.478508965835888 no 1579 0.491290977674078 2335 376585 SGTC_753 1322-0200 289 µM 0.0216583041908884 0.478583846752262 no 1580 0.491360262199523 2347 5403907 SGTC_663 1486-0733 13.9 µM 0.0216334899684871 0.478594543345199 no 1581 0.491370159323099 2336 722445 YPR165W RHO1 SGTC_1832 st054113 55 µM 0.0197256398351052 0.479417000200466 no 1582 0.492131118563213 2372 1251267 SGTC_2987 9018338 71.43 µM 0.0194424466723259 0.479539089754529 no 1583 0.492244074625624 2372 5055682 SGTC_623 k072-0108 16.9 µM 0.0194015423966382 0.47955672446625 no 1584 0.492260389993162 2337 5382803 SGTC_2243 6634756 200 µM 0.0185095071737458 0.479941309900705 no 1585 0.492616196618863 2361 885676 SGTC_2647 atorvastatin 60.16 µM 0.0179932266471997 0.480163903802998 no 1586 0.492822128445085 2347 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2833 9001315 45.46 µM 0.0176591041968441 0.480307963709711 no 1587 0.492955402839614 2331 2989378 SGTC_2440 5628896 157.78 µM 0.0174817277613365 0.48038444220532 no 1588 0.493026154877082 2362 5522048 SGTC_590 k048-0076 22.4 µM 0.0174704439069295 0.480389307431895 no 1589 0.493030655796318 2372 6832814 SGTC_1302 1159-0335 255 µM 0.0173361426869937 0.480447213921065 no 1590 0.49308422611806 2357 649284 SGTC_2450 5739737 12.93 µM 0.0167202286192896 0.48071278208644 no 1591 0.493329904655931 2340 2262825 SGTC_1660 st012960 28.1 µM 0.0164982825426746 0.480808482301052 no 1592 0.493418436117368 2357 24207266 SGTC_874 0599-0792 117 µM 0.0163898485618912 0.480855238002859 no 1593 0.493461689168547 2373 765305 SGTC_1851 st056236 18.9 µM 0.0163193281742614 0.480885645865061 no 1594 0.493489818970571 2377 5393171 SGTC_1421 4029-0249 71.4 µM 0.0160207795108959 0.481014379039393 no 1595 0.493608907084662 2377 2894095 SGTC_2111 5486399 200 µM 0.0153269617264543 0.481313558546845 no 1596 0.493885666330379 2375 689674 SGTC_823 0417-1665 178 µM 0.0146968514424981 0.481585276019556 no 1597 0.494137015636506 2363 3429856 SGTC_1992 st073643 23.3 µM 0.0143795071307598 0.48172212514357 no 1598 0.494263604320858 2372 3161292 SGTC_2183 6420625 130.508 µM 0.0141733081943368 0.481811045944847 no 1599 0.494345857411958 2376 2897619 SGTC_2932 9016711 44.54 µM 0.0133619687874298 0.482160935009594 no 1600 0.494669504321508 2378 7117328 SGTC_425 3825-7017 13.1 µM 0.0126104862603793 0.482485023136114 no 1601 0.494969277189249 2354 3397440 SGTC_319 1348-1596 45.5 µM 0.0123981193639495 0.482576611656644 no 1602 0.495053992699818 2382 5380505 SGTC_1647 st011722 22.4 µM 0.012390401808274 0.48257994006235 no 1603 0.495057071322604 2377 2854783 SGTC_58 0957-0393 9 µM 0.0120072251452446 0.482745196937731 no 1604 0.495209925319809 2377 6997992 SGTC_1977 st070720 65.3 µM 0.0108526194134264 0.483243174446015 no 1605 0.495670516250341 2335 682188 SGTC_1953 st076800 12.1 µM 0.0107958929026572 0.483267641076401 no 1606 0.495693145528191 2364 297591 SGTC_1650 st011916 45.8 µM 0.00792632361778722 0.4845053911345 no 1607 0.496837887491554 2381 242528 SGTC_1583 clindamycin 39.6 µM 0.00702732140204705 0.484893194909733 no 1608 0.497196527448868 2384 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.00634314547982896 0.485188338377399 no 1609 0.497469468046905 2390 6708760 SGTC_2663 amphotericin b 100 µM 0.0056955871234643 0.485467693041037 no 1610 0.497727801769656 2394 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.0054514774631173 0.485573003048764 no 1611 0.497825185921386 2397 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1129 3453-1384 223 µM 0.00403329124822913 0.486184834644252 no 1612 0.498390953954419 2390 1084452 SGTC_1124 fisetin 1.16336 µM 0.00396536295809324 0.486214140984578 no 1613 0.498418053204662 2391 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_650 1328-0195 38 µM 0.00288593608028691 0.486679848614555 no 1614 0.498848679677191 2399 2780821 SGTC_2816 7982706 58.44 µM 0.00219760527019217 0.486976831392064 no 1615 0.499123283047767 2398 2981853 SGTC_1228 0124-0032 52.5 µM 0.00151749756185559 0.487270273377141 no 1616 0.49939460629452 2401 X1228 SGTC_771 0250-0039 27.3 µM 0.000632743487090867 0.487652023190885 no 1617 0.499747571887195 2405 3005115 SGTC_3296 9122258 64.045 µM 0.000618267229751092 0.487658269438037 no 1618 0.49975334707718 2404 4730474 SGTC_542 3381-0244 89.3 µM 0 0.487925043539316 no 1619 0.5 2405 1112843 SGTC_154 3389-1638 511.116 µM -0.000440674399902685 0.488115191997155 no 1620 0.499824196355678 2409 5238686 SGTC_20 0481-0013 4.944 µM -0.00106855316511561 0.488386122713488 no 1621 0.499573709044702 2409 182045 SGTC_3186 9110464 49.47 µM -0.0014521078939774 0.488551629852648 no 1622 0.499420692968977 2410 17018021 SGTC_2520 obtusaquinone 4.71 µM -0.00197198295482525 0.488775963520264 no 1623 0.499213293132969 2411 5967872 SGTC_1132 3456-3614 2.5 µM -0.00275146596579917 0.489112328434533 no 1624 0.49890232527816 2417 3125502 SGTC_315 k915-0449 187 µM -0.00344499248046656 0.48941160765375 no 1625 0.498625649562336 2415 20970215 YNL149C PGA2 SGTC_1611 st001856 99.4 µM -0.00345612417040403 0.489416411388618 no 1626 0.498621208687005 2415 647478 SGTC_2532 xanthone 78.9 µM -0.00428300886291022 0.489773246883123 no 1627 0.498291331901268 2415 7020 An insecticide. SGTC_439 amiodarone 34.4 µM -0.00536433589498635 0.490239897247306 no 1628 0.497859949868936 2426 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1414 3917-0015 5.4 µM -0.00543576036593151 0.490270721198418 no 1629 0.497831456043077 2415 6618702 SGTC_1731 st035964 63 µM -0.00609454328547132 0.490555028330226 no 1630 0.497568644055193 2430 6739575 SGTC_2177 5811945 192 µM -0.00632116679897957 0.490652832044966 no 1631 0.497478236096178 2418 5343475 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.00653150246691948 0.490743606931193 no 1632 0.497394326037982 2415 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2849 9019321 12.99 µM -0.00669545834807917 0.490814365954574 no 1633 0.497328918535357 2429 16489627 SGTC_2518 prenyletin 46.28 µM -0.00790886047888884 0.491338047070913 no 1634 0.496844854057645 2424 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2001 4023502 57.655 µM -0.00806276048069502 0.491404468449376 no 1635 0.496783458797748 2430 108941 YCR052W RSC6 SGTC_1367 1812-0510 76.9 µM -0.00826311534954194 0.491490939543153 no 1636 0.496703531432581 2424 1142582 YDR527W RBA50 SGTC_68 0986-0284 82.829 µM -0.00872095548893654 0.491688540116958 no 1637 0.496520886230724 2480 423278 YIL048W NEO1 SGTC_2258 7960471 200 µM -0.00898846067998187 0.491803994417125 no 1638 0.496414171283728 2433 2974708 SGTC_452 diindolylmethane 8 µM -0.0100737593641195 0.492272412457215 no 1639 0.495981219438574 2431 3071 Inhibits expression of several cancer promoting factors. SGTC_2381 9035592 200 µM -0.0104606490194383 0.492439397757534 no 1640 0.495826880933228 2442 4749657 SGTC_2439 5492030 7.2 µM -0.0105114706988342 0.49246133298277 no 1641 0.495806607131216 2429 5722370 SGTC_1359 1582-0056 520 nM -0.0107631178208471 0.49256994712879 no 1642 0.495706220134426 2432 3661189 SGTC_2408 sulbentine 18.36 µM -0.0113555587478159 0.492825654440541 no 1643 0.495469884856877 2488 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3083 9117465 49.47 µM -0.0124694183772751 0.493306422594784 no 1644 0.495025550707489 2466 16420915 SGTC_1214 0358-0031 63.7 µM -0.0126116159600686 0.493367799148375 no 1645 0.494968826540116 2444 4301366 SGTC_2651 TUB2.036 5 µM -0.0130337131240225 0.493549989305163 no 1646 0.494800447979258 2434 15992207 YFL037W TUB2 SGTC_221 trifluoperazine 10.304 µM -0.0130771700379653 0.493568746726813 no 1647 0.494783112656331 2414 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1983 st071813 46.9 µM -0.0138041520416598 0.493882537950668 no 1648 0.494493114999771 2465 11838595 SGTC_1841 st054148 70 µM -0.014188599450318 0.494048480633767 no 1649 0.494339757696782 2451 675442 SGTC_2132 5317594 122.667 µM -0.0142147962693259 0.494059788253147 no 1650 0.494329307731939 2438 794577 SGTC_2482 5981709 142.65 µM -0.014425999602539 0.494150952430379 no 1651 0.49424505843182 2444 877755 SGTC_191 3914-0123 66.505 µM -0.0144394011483482 0.494156737107477 no 1652 0.494239712545385 2437 3144412 SGTC_276 colchicine 750 µM -0.0147653063259294 0.494297412017238 no 1653 0.4941097090522 2474 2833 A microtubule depolymerizer. SGTC_557 1315-0110 16.2 µM -0.0148681219910102 0.494341791897123 no 1654 0.494068696038473 2441 6833801 SGTC_2003 4023581 200 µM -0.0164245743128784 0.495013635181547 no 1655 0.493447837462802 2462 16641307 SGTC_2583 asiatic acid 100 µM -0.0164350342109463 0.495018150250824 no 1656 0.493443665130389 2465 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2687 chenodiol 100 µM -0.0171219946161107 0.495314681644364 no 1657 0.49316964615862 2441 5702181 A cholesterol synthesis inhibitor. SGTC_1348 1493-0373 93.8 µM -0.0181227671213851 0.495746676873348 no 1658 0.492770457698322 2444 3010129 SGTC_1618 st003135 44.5 µM -0.0185973401332138 0.49595153367312 no 1659 0.492581162368161 2437 1270615 SGTC_2850 9015429 58.44 µM -0.0196945607996401 0.496425169985452 no 1660 0.492143514896346 2457 6457570 SGTC_2730 imipramine 71.33 µM -0.0197987771954544 0.496470157260955 no 1661 0.492101946674921 2448 3696 A tricyclic antidepressant. SGTC_4 0960-0234 25.671 µM -0.0201621687932453 0.49662702350073 no 1662 0.491957003337994 2408 6821112 SGTC_2598 perillyl alcohol 100 µM -0.0203814208010531 0.496721668865313 no 1663 0.491869552412827 2461 10819 An apoptosis inducer. SGTC_545 4218-0007 221 µM -0.0217010647756116 0.497291328407459 no 1664 0.491343207202813 2466 2840508 SGTC_2420 aureobasidin a 50 nM -0.0219339800824059 0.497391873122554 no 1665 0.491250309551861 2467 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2147 5545932 89.7195 µM -0.0220470684061405 0.497440691070394 no 1666 0.491205204745408 2449 797404 SGTC_3062 9077494 49.47 µM -0.0220884906978962 0.497458572247693 no 1667 0.491188683665142 2441 16459633 SGTC_2135 5326629 150.42 µM -0.0224909519753089 0.497632307015558 no 1668 0.49102816472684 2461 5020077 SGTC_292 k038-0015 474 µM -0.022991453133447 0.497848364330945 no 1669 0.490828545280052 2461 46368540 SGTC_662 k832-1615 104 µM -0.0235761961349076 0.498100788124307 no 1670 0.490595329802801 2469 5878478 SGTC_883 0850-0245 24.6 µM -0.0245952129637934 0.498540682437516 no 1671 0.4901889188238 2562 6823229 YPR165W RHO1 SGTC_509 pifithrin 175 µM -0.0257074529754306 0.49902082181004 no 1672 0.489745339604041 2448 4817 A p53 inhibitor. SGTC_79 0052-0007 94.094 µM -0.026623945491654 0.499416460661969 no 1673 0.489379837143354 2448 2801472 SGTC_844 0330-0132 15.3 µM -0.0271054126309455 0.499624304519074 no 1674 0.489187828846471 2449 2828079 SGTC_2335 9018011 154.17 µM -0.0274044373815947 0.499753390138664 no 1675 0.489068579530262 2493 6458208 SGTC_799 1310-0557 151 µM -0.0278532349238342 0.499947131031041 no 1676 0.488889603540754 2537 5354492 SGTC_2689 tacrolimus 100 µM -0.0280981750725371 0.499947131031041 no 1677 0.488791924790644 2481 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2346 9031566 143.75 µM -0.0287386747722126 0.49967063447092 no 1678 0.48853650554422 2492 4771086 SGTC_172 1112-0046 2.638 µM -0.0287480491999775 0.499666587636103 no 1679 0.48853276723321 2471 2802135 YIL048W NEO1 SGTC_1017 4239-0030 168 µM -0.0296326723916562 0.499284705986547 no 1680 0.488180003974101 2475 1149593 SGTC_2383 9036125 200 µM -0.0300425296300364 0.499107775535283 no 1681 0.488016567362493 2461 79580 SGTC_1002 4049-0206 172 µM -0.0301251563636181 0.499072106586103 no 1682 0.487983618978123 2471 4662749 SGTC_3067 9117431 49.47 µM -0.0307759058620822 0.498791186277689 no 1683 0.487724127826323 2476 17150885 SGTC_611 3453-1652 23.7 µM -0.0308576676303414 0.498755890798405 no 1684 0.487691525084723 2462 1560575 SGTC_1545 lovastatin 49.4 µM -0.0315191132921059 0.49847035379363 no 1685 0.487427774757104 2470 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.0317809434069944 0.498357325538589 no 1686 0.487323371958798 2485 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1800 st050079 29.0735 µM -0.033737472945758 0.497512724967483 no 1687 0.48654324844053 2459 3645560 SGTC_1489 4065-0444 182 µM -0.0345843019482752 0.497147166505064 no 1688 0.486205609621275 2462 2877968 SGTC_672 1441-0018 53.7 µM -0.0350102638782725 0.496963288488145 no 1689 0.486035778250206 2491 251141 SGTC_226 1,3-diallylurea 8.28947 mM -0.0350524895733027 0.496945060656455 no 1690 0.486018942968417 2527 74537 YKL182W FAS1 SGTC_69 0096-0274 206.684 µM -0.0359978437808358 0.496536975393104 no 1691 0.485642039127541 2691 6741392 SGTC_837 0091-0265 12.5 µM -0.0363553679939433 0.496382642244184 no 1692 0.485499500907169 2473 759367 SGTC_1932 st074806 40.9 µM -0.0377863063260121 0.495764952056457 no 1693 0.484929031272281 2639 17251235 SGTC_645 0845-0943 5.41 µM -0.0398321934698923 0.494881826192444 no 1694 0.484113454956461 2499 1885106 SGTC_809 3998-0021 90 µM -0.0402710624624322 0.494692387504862 no 1695 0.483938511933399 2468 715485 SGTC_1275 0867-0008 21.1 µM -0.0403145776754655 0.494673604139736 no 1696 0.483921165961488 2486 3422836 SGTC_245 methotrexate 289.6 µM -0.0403951289092482 0.494638834187513 no 1697 0.483889056824342 2501 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2499 avocadenofuran 51.48 µM -0.0404537886377474 0.494613513732466 no 1698 0.48386567409159 2489 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2016 5121758 140 µM -0.0411945000600132 0.494293787759781 no 1699 0.483570419134502 2479 2795203 SGTC_1604 st002052 72.4 µM -0.0413892621418805 0.494209719862906 no 1700 0.483492786516329 2577 6254834 YHR062C RPP1 SGTC_3180 9109287 49.47 µM -0.0415253882643429 0.494150961982407 no 1701 0.483438526699134 2533 18891271 SGTC_1571 st070080 73.4 µM -0.0421627128121783 0.493875867045827 no 1702 0.483184493488833 2517 4315245 SGTC_1103 duloxetine 36.1 µM -0.0426730819981265 0.493655573248972 no 1703 0.48298106873534 2568 60835 A selective serotonin reuptake inhibitor. SGTC_1148 3909-7663 27.7 µM -0.0446347723954844 0.492808855337575 no 1704 0.482199212952794 2596 4084526 SGTC_1655 st012546 55.1 µM -0.0457597171919585 0.492323313523408 no 1705 0.481750883090009 2539 720985 YLR208W SEC13 SGTC_1698 5-fluorocytosine 1.055 µM -0.0477531369185194 0.491462954243886 no 1706 0.48095649261835 2499 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2903 5923464 63.88 µM -0.0486315448810582 0.491083846033948 no 1707 0.480606465259562 2499 2876576 SGTC_784 4579-0127 173 µM -0.0489408976370644 0.490950335745434 no 1708 0.480483198147187 2627 1948547 SGTC_1527 coumarin 137 µM -0.0491608851771929 0.490855394262524 no 1709 0.480395541330608 2671 323 A hepatotoxic, DNA x-linker. SGTC_2229 7354935 190 µM -0.0493535581775193 0.490772241522273 no 1710 0.48031876911633 2488 318112 SGTC_2363 9053361 176 µM -0.0493594512668162 0.490769698221923 no 1711 0.480316420975701 2526 6469797 YMR079W SEC14 SGTC_851 0394-0702 453 µM -0.050299279702312 0.490364098177943 no 1712 0.479941948879604 2492 762646 SGTC_2907 7721985 69.9 µM -0.0509473530666271 0.490084416116964 no 1713 0.479683736093914 2541 3267881 SGTC_446 go6976 132 µM -0.0517876435582767 0.489721788253852 no 1714 0.47934895067603 2493 3501 A protein kinase C inhibitor. SGTC_3170 9103054 49.47 µM -0.0528198650023144 0.489276344133068 no 1715 0.478937716805077 2538 16432970 SGTC_197 4544-0043 41.561 µM -0.052828440923047 0.489272643341482 no 1716 0.478934300277754 2506 896523 SGTC_2919 7978188 46.38 µM -0.0543866971825495 0.488600220212287 no 1717 0.478313538639524 2496 2980291 SGTC_2025 5147754 141 µM -0.0546464706403006 0.488488125137792 no 1718 0.47821005791386 2538 315777 YLR208W SEC13 SGTC_1487 3970-0795 2.82 µM -0.0547261246452026 0.48845375374945 no 1719 0.478178328044533 2541 3765103 SGTC_2331 7980721 200 µM -0.0551100113260945 0.488288104551345 no 1720 0.478025410191218 2576 2981221 SGTC_1803 st050068 52.4 µM -0.0556549848533413 0.48805294897659 no 1721 0.477808330383477 2488 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_77 0828-0286 12.516 µM -0.0558682678220523 0.487960918698464 no 1722 0.47772337497089 2498 745345 SGTC_2428 5615643 7.78 µM -0.0562868105527815 0.487780321974036 no 1723 0.477556662915748 2548 2253075 SGTC_1519 esterone 74 µM -0.0573727586562806 0.487311758725668 no 1724 0.477124131345662 2510 698 A steroid. SGTC_2451 5856223 45.7 µM -0.0583944460041518 0.486870938589912 no 1725 0.476717219335896 2532 2179896 SGTC_504 lovastatin 124 µM -0.0591885144420479 0.486528338608921 no 1726 0.476400978876111 2524 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1188 1403-0014 4.57 µM -0.0598144098606019 0.48625830369218 no 1727 0.476151724358708 2527 9614867 SGTC_2720 fluspirilene 36.88 µM -0.0598694353635952 0.486234563911997 no 1728 0.476129811629565 2570 3396 An atypical antipsychotic. SGTC_371 0195-0006 7.36 µM -0.0600646616570398 0.486150337374268 no 1729 0.476052067518467 2493 3928593 SGTC_558 k064-0027 21.3 µM -0.0602891692690592 0.486053478752574 no 1730 0.475962663963397 2565 5088526 SGTC_1910 st062352 60.4 µM -0.0606739352266254 0.485887482287138 no 1731 0.475809445051026 2503 2245730 SGTC_1511 0906-3109 28.5 µM -0.0610345137892515 0.485731923012934 no 1732 0.475665861126679 2507 2882180 SGTC_304 1310-0298 97 µM -0.0620078735446181 0.485312011183668 no 1733 0.475278280943786 2531 1550234 SGTC_1342 1486-1464 234 µM -0.0626495058216875 0.485035216976331 no 1734 0.475022803434531 2508 3253938 SGTC_2807 7945238 51.95 µM -0.062857397768434 0.484945535860735 no 1735 0.474940029689255 2570 17148797 SGTC_1194 1488-0194 225 µM -0.0629586332846902 0.484901864824303 no 1736 0.474899722396929 2511 1391452 SGTC_3178 9107506 49.47 µM -0.0636373436050846 0.484609087070437 no 1737 0.474629498046976 2590 8897194 SGTC_112 phenothiazine 287.218 µM -0.0639271985868684 0.484484053785804 no 1738 0.474514097613616 2523 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_258 haloperidol 50.781 µM -0.0645967581113663 0.484195235116544 no 1739 0.474247532986535 2527 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1116 jasmonic acid  1.58368 µM -0.0649126712008645 0.484058966908558 no 1740 0.474121765857003 2618 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1702 st027038 51 µM -0.0652134222568949 0.483929240530071 no 1741 0.474002037231321 2563 5521182 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0652176605318464 0.483927412398786 no 1742 0.474000349996027 2722 6710655 SGTC_3115 9123671 49.47 µM -0.0654052371442044 0.483846503717596 no 1743 0.47392567718623 2517 3286988 SGTC_2138 5575593 77.673 µM -0.0662395236373621 0.483486653420378 no 1744 0.473593565271264 2522 762213 SGTC_2969 9091408 28.7 µM -0.0667967152728633 0.483246329092434 no 1745 0.473371769201742 2570 4286311 SGTC_2062 5245942 200 µM -0.0675847575684062 0.482906446148603 no 1746 0.473058094675885 2511 1376160 SGTC_2751 anetholtrithion 17.25 µM -0.0676883787533104 0.482861755210637 no 1747 0.473016850252619 2583 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.0680160627763032 0.482720429291327 no 1748 0.472886423824322 2509 279621 SGTC_1521 st012942 49.4 µM -0.0680519880552127 0.48270493531072 no 1749 0.472872124842292 2734 24207259 SGTC_3162 9099653 49.47 µM -0.0686144021318041 0.482462378810327 no 1750 0.472648277321216 2527 25237511 SGTC_2502 avocadyne acetate 18.59 µM -0.0687647451173767 0.482397540368951 no 1751 0.472588440477227 2505 3952079 SGTC_551 k048-0028 34.9 µM -0.0701914796360788 0.481782255778467 no 1752 0.472020627932731 2570 6836383 SGTC_1609 st001574 46.4 µM -0.0704528274036268 0.481669553236467 no 1753 0.47191662274037 2542 3960012 SGTC_2893 9048488 25.97 µM -0.0710725587448781 0.481402308700543 no 1754 0.471670003937798 2562 6467338 SGTC_1357 1503-1303 39.5 µM -0.0715037640016434 0.481216366519012 no 1755 0.471498414494032 2534 292895 SGTC_1964 st076914 61 µM -0.0715252056740673 0.481207120654221 no 1756 0.471489882350323 2512 24208661 SGTC_895 0964-0006 13.7 µM -0.0723880320203814 0.480835069698255 no 1757 0.471146554436202 2514 6738897 SGTC_1741 st038134 10.228 µM -0.0726621770373377 0.480716861771308 no 1758 0.471037473652388 2617 1272587 SGTC_917 harmaline 728.087 nM -0.0730559892400652 0.48054705780989 no 1759 0.470880781762837 2607 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2983 9022671 12.99 µM -0.0732914651613332 0.480445526976988 no 1760 0.470787091625071 2725 6405161 SGTC_2463 5473429 200 µM -0.0740219774146166 0.480130558000876 no 1761 0.470496448891486 2619 5399405 SGTC_1742 st038235 28.8875 µM -0.0747432607697345 0.479819580343356 no 1762 0.470209493400161 2630 564103 YBR002C RER2 SGTC_3081 9117243 49.47 µM -0.0747704616404717 0.47980785306515 no 1763 0.470198672102934 2685 45595589 SGTC_833 3852-0053 558 µM -0.0751812091492717 0.479630767103352 no 1764 0.470035267481699 2623 3123681 SGTC_1773 st048542 73.5835 µM -0.075195447183419 0.479624628718124 no 1765 0.470029603360981 2536 3237138 SGTC_2035 5154463 94.595 µM -0.0772887786507756 0.478722192665682 no 1766 0.469196908772229 2575 2769623 SGTC_3044 9093193 49.47 µM -0.0773321959161088 0.478703476603445 no 1767 0.469179639475111 2624 25236277 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.0778067298602755 0.478498920341013 no 1768 0.468990896513326 2551 688798 SGTC_839 0122-0028 230 µM -0.0782117143476564 0.478324349081177 no 1769 0.468829821930635 2548 759448 SGTC_164 4100-3994 89.624 µM -0.0785792175280853 0.478165937986432 no 1770 0.468683659212408 2531 4615967 SGTC_696 1560-0013 611 µM -0.079165240510733 0.477913341761423 no 1771 0.468450595922622 2653 1650269 SGTC_1306 1185-0270 9.02 µM -0.0792548892466309 0.477874700827742 no 1772 0.468414943273659 2567 1548076 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.0795723095563531 0.477737886104149 no 1773 0.468288709567896 2553 16623 A steroid. SGTC_648 0375-0473 33.3 µM -0.0797049351526814 0.477680722503189 no 1774 0.468235967130021 2554 1713139 SGTC_3337 9144342 33.5465 µM -0.0802238214455013 0.477457079231398 no 1775 0.468029622222937 2633 17682949 SGTC_2852 9023854 51.95 µM -0.0814876248614836 0.476912401814613 no 1776 0.467527083039452 2639 19798528 SGTC_298 1391-0729 10 µM -0.0815148860613609 0.476900653180459 no 1777 0.467516243454781 2543 3237558 SGTC_2213 7173844 200 µM -0.0819418614524569 0.476716644182849 no 1778 0.467346472861372 2554 892728 SGTC_3183 9108214 49.47 µM -0.0820124086168039 0.476686241706118 no 1779 0.467318423024251 2540 4974831 SGTC_2643 anethole 100 µM -0.0826785693288237 0.47639916479831 no 1780 0.467053562858734 2553 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_714 4296-0578 26.1 µM -0.0838011925772414 0.475915406612571 no 1781 0.46660724990877 2599 1589775 SGTC_272 doxorubicin 8.13 µM -0.0840538235044841 0.475806548351642 no 1782 0.46650681908308 2528 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_770 0389-1121 67.2 µM -0.084787260490284 0.475490521792373 no 1783 0.466215260861872 2743 6753108 SGTC_2649 anisomycin 9.56 µM -0.085477151396894 0.475193272628204 no 1784 0.465941029762411 2599 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3318 9139014 38.6185 µM -0.0856905104939395 0.475101346659112 no 1785 0.465856222954915 2544 16643984 SGTC_3262 9137218 49.47 µM -0.0859177050503133 0.475003461126511 no 1786 0.465765918479652 2526 17650664 SGTC_3079 9117512 49.47 µM -0.0871453975789557 0.474474542766519 no 1787 0.465277970284232 2530 7185044 SGTC_1866 st057638 64 µM -0.0873918155728767 0.474368385581736 no 1788 0.465180037358238 2591 688802 SGTC_70 0141-0289 43.283 µM -0.0876764129915942 0.47424578291742 no 1789 0.465066933559655 2675 352408 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.0890019273932591 0.473674792500339 no 1790 0.464540189181243 2610 4213774 SGTC_2607 solasodine 47.35 µM -0.08977635851909 0.4733412165877 no 1791 0.464232467740307 2600 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2060 5238662 140 µM -0.0899162772796144 0.473280950428564 no 1792 0.464176873074508 2651 790130 SGTC_1863 st057641 20.1 µM -0.0900342267512945 0.473230147411582 no 1793 0.464130008126449 2565 3921635 SGTC_2896 9052656 71.43 µM -0.0904098850335547 0.473068347353556 no 1794 0.463980750871918 2568 6469436 SGTC_456 gingerol 170 µM -0.0906005584133718 0.472986223978735 no 1795 0.463904994104547 2690 442793 A herb. SGTC_3284 9108171 64.8615 µM -0.0907628768288928 0.472916314043752 no 1796 0.46384050412778 2640 8687505 SGTC_2455 5377712 9.75 µM -0.0908395080508015 0.472883309552611 no 1797 0.463810058462499 2629 2243908 SGTC_2193 5925765 200 µM -0.0911135678060441 0.472765275601523 no 1798 0.463701175968296 2645 877370 SGTC_1286 0929-0070 131 µM -0.0911779171468248 0.472737561528619 no 1799 0.463675610708691 2649 1420408 SGTC_1081 sertraline 6 µM -0.09132800332226 0.472672922697219 no 1800 0.463615983765045 2595 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2602 kawain 100 µM -0.0918417372759707 0.472451674183299 no 1801 0.463411891311807 2531 5369129 SGTC_2964 9083345 53.42 µM -0.093634660809387 0.471679587337219 no 1802 0.462699687607081 2612 17741579 SGTC_2094 5332512 191.667 µM -0.0939110951208336 0.471560555797283 no 1803 0.46258989007982 2665 755774 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.0944707290299642 0.471319587399699 no 1804 0.462367616641929 2607 2374 Ca(2+)-ATPase inhibitor. SGTC_1724 st037281 8.293 µM -0.0945598141148831 0.471281229914624 no 1805 0.462332235222001 2575 574124 YDL195W SEC31 SGTC_3275 9138069 49.47 µM -0.0950114296435285 0.47108678131377 no 1806 0.462152874224843 2655 17617007 SGTC_1419 3993-2473 62.6 µM -0.0956330261336373 0.470819156608649 no 1807 0.461906017170987 2589 704026 SGTC_3260 9137109 49.47 µM -0.0957294939893086 0.470777624120229 no 1808 0.461867707825817 2537 17478346 SGTC_847 0342-0274 5.54 µM -0.0958761994849103 0.470714463335035 no 1809 0.461809448771509 2675 18097 SGTC_881 0833-0569 170 µM -0.0960110918544534 0.470656389078346 no 1810 0.461755881618015 2579 5418700 SGTC_2960 9079389 5.97 µM -0.0963625844924362 0.470505066376602 no 1811 0.461616303521783 2620 16457355 SGTC_3131 9127911 49.47 µM -0.096999760467245 0.470230763709271 no 1812 0.461363292336466 2771 45595681 SGTC_1004 4084-0029 199 µM -0.0976731732567919 0.469940876539497 no 1813 0.461095909158455 2639 716894 YLR208W SEC13 SGTC_1097 itavastatin 7.23 µM -0.0991772814478281 0.469293453770557 no 1814 0.460498756345817 2590 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_736 0958-0254 92.6 µM -0.0998751263010774 0.468993103478024 no 1815 0.460221731965236 2666 6812352 SGTC_763 3453-1109 128 µM -0.099891932222001 0.468985870477913 no 1816 0.460215060734459 2573 1560353 SGTC_2396 5342950 42.78 µM -0.100710870209088 0.468633425088077 no 1817 0.459889991035805 2630 1886677 SGTC_740 k014-0057 261 µM -0.101328765030063 0.468367518666927 no 1818 0.459644741256235 2687 4012779 SGTC_65 0798-0905 34.986 µM -0.101880889042168 0.468129928156873 no 1819 0.45942560967774 2806 3602145 SGTC_1371 2421-0008 32.7 µM -0.102506435361019 0.467860756213253 no 1820 0.459177352539575 2651 2827552 SGTC_953 1188-0045 9.7 µM -0.10272415420782 0.4677670754561 no 1821 0.459090951383836 2687 6144426 SGTC_3206 9114350 49.47 µM -0.103030548502531 0.467635242170439 no 1822 0.458969362882278 2619 17087243 SGTC_1682 st012968 530 nM -0.103374395921378 0.46748729803316 no 1823 0.458832916177677 2609 24207270 SGTC_1104 tacrolimus 29.8 µM -0.10434953302575 0.467067759054609 no 1824 0.458445985381902 2579 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_3199 9111318 49.47 µM -0.104756274532478 0.46689277504657 no 1825 0.45828460347151 2670 8548020 SGTC_2236 dapsone 200 µM -0.106037185859225 0.466341756950996 no 1826 0.457776424220619 2600 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_3163 9099914 49.47 µM -0.106314401054925 0.466222513912225 no 1827 0.45766645297827 2601 16268368 SGTC_1607 st000305 50.6 µM -0.107047910259395 0.465907012433292 no 1828 0.45737548560069 2722 5457690 SGTC_233 rapamycin 362 pM -0.107078009477497 0.465894066429242 no 1829 0.457363546373006 2632 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2370 9071495 200 µM -0.107249311760607 0.465820388124813 no 1830 0.457295597933576 2652 21791103 SGTC_967 1306-0166 352 µM -0.107738641045436 0.465609930654552 no 1831 0.457101508388251 2623 4437607 SGTC_1927 st060202 13.8 µM -0.107754160981559 0.465603255783977 no 1832 0.457095352665225 2569 688887 SGTC_274 sirtinol 40.1 µM -0.108310966993733 0.465363789044903 no 1833 0.45687451169665 2630 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1656 st012921 11 µM -0.109587886728503 0.464814668976364 no 1834 0.456368108891411 2683 6732821 SGTC_635 k038-0028 24.7 µM -0.109629144374901 0.464796927859724 no 1835 0.456351748047457 2628 4035102 SGTC_1054 3429-0080 167 µM -0.109732320937001 0.46475256142245 no 1836 0.456310833394962 2664 1162877 SGTC_2170 morpholine 200 µM -0.110809098059078 0.464289568132606 no 1837 0.45588386528913 2693 121171 Reacts with secondary amines. SGTC_473 2-arachidonoylglycerol 10 µM -0.111224932554614 0.464110780267749 no 1838 0.455718990488031 2576 5282280 An endocannabinoid. SGTC_2726 cimetidine 79.27 µM -0.11148727932894 0.463997988109431 no 1839 0.455614976169531 2600 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_808 0711-0032 135 µM -0.111606840971442 0.463946585289317 no 1840 0.455567573802344 2578 4252555 SGTC_1113 artemisinin 1.17947 µM -0.111718673514157 0.463898505965294 no 1841 0.455523236348517 2602 2240 An anti-malaria and mitochondrial poison. SGTC_1450 4112-4260 37.6 µM -0.111824993744265 0.463852796997245 no 1842 0.45548108483576 2584 1633175 SGTC_902 1120-0002 2.07 µM -0.112239265703273 0.463674698631476 no 1843 0.455316848161266 2613 3280475 SGTC_3016 9080866 49.47 µM -0.112333361451729 0.463634247234954 no 1844 0.455279545292931 2613 17066299 SGTC_1801 st050089 28.441 µM -0.112481711266267 0.463570472990087 no 1845 0.45522073500318 2592 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2377 9073351 62.6 µM -0.114815945933811 0.462567130899761 no 1846 0.4542955048087 2595 7337946 YHR072W ERG7 SGTC_1972 st070201 17.4 µM -0.114824532970997 0.462563440303039 no 1847 0.454292101584129 2668 2829099 SGTC_3073 9114972 49.47 µM -0.11521734732599 0.462394617261042 no 1848 0.454136424533492 2648 41905075 SGTC_131 0141-0277 33.849 µM -0.115902945573879 0.462099978335382 no 1849 0.453864730600755 2728 1547771 SGTC_1288 0973-0013 65.5 µM -0.116953532195522 0.461648524422879 no 1850 0.453448438312955 2697 4315430 SGTC_2448 5185112 27.17 µM -0.117574694974351 0.4613816240262 no 1851 0.453202328166368 2732 5718189 SGTC_2162 5663267 200 µM -0.118524624470095 0.460973493261608 no 1852 0.45282599255245 2625 6456493 SGTC_1944 st076371 56.9 µM -0.118684138699285 0.460904963073949 no 1853 0.452762801602396 2616 24208455 SGTC_2343 7990716 14.84 µM -0.12141566056943 0.459731633903985 no 1854 0.451680906652754 2644 6456862 SGTC_3332 9141069 11.198 µM -0.122030699932316 0.459467490853586 no 1855 0.451437352464837 2626 17332883 SGTC_3059 1327-0034 3 µM -0.122094075222724 0.459440273866491 no 1856 0.451412257031328 2659 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3058 9093861 49.47 µM -0.122185958959467 0.459400814053928 no 1857 0.451375873129426 2744 17217477 SGTC_1608 st001473 40.5 µM -0.122209619334306 0.459390653082673 no 1858 0.451366504217015 2619 7292267 SGTC_1685 st024049 53.0905 µM -0.122782930261202 0.459144452265404 no 1859 0.451139495825456 2684 1941139 SGTC_941 3237-0776 460 µM -0.123470851255455 0.458849054354392 no 1860 0.450867127488784 2753 760008 SGTC_1158 4092-0494 91.8 µM -0.123962418539202 0.458637985959307 no 1861 0.450672515577113 2756 1148199 SGTC_252 miconazole 1.30953 nM -0.124300954202694 0.458492632820131 no 1862 0.450538495908678 2646 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_137 0438-0332 85.389 µM -0.125221049005497 0.458097610460607 no 1863 0.450174276852407 2601 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2355 9061122 103.12 µM -0.125847276304207 0.457828777260578 no 1864 0.4499264090771 2745 5302957 SGTC_2202 7226349 200 µM -0.126806010345288 0.457417239615558 no 1865 0.449546969288021 2623 844334 SGTC_158 k038-0087 26.446 µM -0.128255903728886 0.456794958153894 no 1866 0.448973230274706 2625 X158 SGTC_81 0411-0046 9.971 µM -0.128465569382875 0.456704980234155 no 1867 0.448890272033455 2605 12925265 SGTC_12 0849-0099 9.267 µM -0.128707185081553 0.456601293720499 no 1868 0.448794674914981 2594 6071388 SGTC_857 0438-0306 1.35 µM -0.129217818976581 0.456382170965804 no 1869 0.448592648455169 2712 4686136 SGTC_2913 7966556 36.57 µM -0.12943359856473 0.456289579807168 no 1870 0.448507281732814 2640 2976516 SGTC_3036 9090181 49.47 µM -0.129519053518102 0.456252911688104 no 1871 0.448473474702343 2619 25236586 SGTC_1923 st058458 19.1 µM -0.1295342937106 0.456246372267901 no 1872 0.448467445534078 2846 3534982 SGTC_2 0422-0095 29 µM -0.130808966526963 0.455699464526628 no 1873 0.44796321484305 2581 6790840 SGTC_283 0987-0079 11.7 µM -0.130936902529587 0.455644577262159 no 1874 0.447912610987855 2694 411556 SGTC_2265 7929201 200 µM -0.131864762524182 0.455246531001105 no 1875 0.447545630310775 2608 1265108 SGTC_956 1185-0240 191 µM -0.132870423526646 0.454815159328919 no 1876 0.447147929037526 2679 1416193 SGTC_1775 st081588 35.1725 µM -0.134494636598546 0.454118576544746 no 1877 0.446505725966655 2640 1426443 YGL099W LSG1 SGTC_1967 st070177 51.4 µM -0.134581269945356 0.454081425698193 no 1878 0.446471475641967 2774 5729214 SGTC_1184 1269-1718 139 µM -0.135373219279271 0.453741833930762 no 1879 0.446158398559434 2775 5403821 SGTC_3097 9117246 49.47 µM -0.135796636330186 0.45356028447618 no 1880 0.445991025124646 2624 16423892 SGTC_1278 0874-0585 172 µM -0.136302288901886 0.453343487435578 no 1881 0.445791157245404 2702 766306 SGTC_1903 st060211 78.3 µM -0.137142652009698 0.452983215032516 no 1882 0.445459019761747 2787 688960 SGTC_3196 9111891 49.47 µM -0.137258731622503 0.452933453530642 no 1883 0.445413144513199 2600 18891510 SGTC_529 4076-0302 30.3 µM -0.137822722186439 0.452691690192049 no 1884 0.445190263011266 2671 5816522 SGTC_2426 5582046 32.21 µM -0.138967837803562 0.452200872594182 no 1885 0.444737782056659 2777 2251934 SGTC_212 3807-4682 38.772 µM -0.139273565163713 0.452069844551552 no 1886 0.44461698910905 2725 3125501 YBL034C STU1 SGTC_1570 verbenone 133 µM -0.140637699353847 0.451485270360562 no 1887 0.444078082216601 2770 29025 A natural terpanoid with antifungal properties. SGTC_180 1486-1293 102.781 µM -0.140926401539849 0.451361565882951 no 1888 0.443964042437268 2676 4140536 SGTC_2650 prasterone 100 µM -0.140968427488465 0.45134355879933 no 1889 0.443947442222525 2649 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_909 3448-9333 149 µM -0.142759556575688 0.450576197651454 no 1890 0.443240039507597 2657 3344074 SGTC_1218 1348-1416 30.7 µM -0.142841602305636 0.450541051764702 no 1891 0.443207640031984 2642 6787668 SGTC_1786 berberine 21.6 µM -0.143794921202293 0.450132707548034 no 1892 0.442831206744864 2653 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1722 st034304 3.6505 µM -0.14390774467111 0.450084384275756 no 1893 0.442786659993168 2693 4036148 YLR033W RSC58 SGTC_443 clozapine 122 µM -0.144293207619769 0.449919292732523 no 1894 0.442634470857174 2625 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_424 splitomicin 100 mM -0.145208424926783 0.449527345243388 no 1895 0.442273157154197 2756 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_855 0428-0020 25 µM -0.145238170721363 0.449514607246436 no 1896 0.442261414776458 2678 6812414 SGTC_975 1335-0046 28.5 µM -0.14554287054064 0.449384129098485 no 1897 0.442141135137777 2695 16486740 SGTC_968 1309-0633 340 µM -0.14584530086598 0.449254628201943 no 1898 0.442021756651684 2714 3761976 SGTC_617 3770-0098 35 µM -0.146239822624797 0.449085701809925 no 1899 0.441866034780389 2680 5962639 SGTC_2070 5230947 200 µM -0.149137371604423 0.447845313556644 no 1900 0.440722618676536 2715 2835538 SGTC_2033 5192550 145 µM -0.151014323788297 0.447042095628046 no 1901 0.439982208367073 2706 182073 SGTC_2845 9003024 42.97 µM -0.151039472010817 0.447031335231611 no 1902 0.439972289446286 2895 2990173 SGTC_1743 st037606 46.3785 µM -0.151513312907669 0.446828595957695 no 1903 0.439785404944432 2699 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_476 mead acid 10 µM -0.151799681402893 0.446706076034454 no 1904 0.439672466713174 2674 5312531 An omega 9 fatty acid. SGTC_2327 6189656 200 µM -0.153178185298804 0.446116368186735 no 1905 0.439128880125556 2776 5349088 SGTC_3237 9133362 49.47 µM -0.153966618203205 0.445779139294224 no 1906 0.438818028251257 2740 43845137 SGTC_2752 diclazuril 33.15 µM -0.154676899607522 0.445475370973896 no 1907 0.43853802111786 2803 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_171 k064-0041 9.68 µM -0.154984807434379 0.445343696983413 no 1908 0.438416647244887 2697 53325 SGTC_264 promethazine 12.5 mM -0.155223274241137 0.445241722957834 no 1909 0.438322650236287 2687 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1900 st060200 72.8 µM -0.156157973280822 0.444842058618808 no 1910 0.437954251364874 2659 688945 SGTC_1709 st033179 39.1045 µM -0.156351859400577 0.44475916261211 no 1911 0.437877840519522 2688 573381 SGTC_117 lucigenin 22.078 µM -0.156833022558261 0.444553451758322 no 1912 0.437688223324102 2714 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_230 MPP+ 141.667 µM -0.15934859340619 0.44347821848035 no 1913 0.436697118909135 2714 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.161037736676209 0.442756459036051 no 1914 0.436031839468108 2861 1273210 SGTC_3005 9076496 71.4286 µM -0.16229328321573 0.442220095449719 no 1915 0.43553745188997 2745 21368410 SGTC_1816 st051957 91.6 µM -0.162414874192494 0.442168157964411 no 1916 0.435489579218659 2708 674121 SGTC_1028 k015-0029 4.8 µM -0.163313738691028 0.441784239632 no 1917 0.435135708607428 2679 4588309 SGTC_2822 7994718 71.43 µM -0.163785680219509 0.441582688289129 no 1918 0.434949932485797 2658 1018011 SGTC_2935 9038016 29.96 µM -0.164049396542171 0.441470069948878 no 1919 0.43484612885236 2753 6463195 SGTC_1362 1611-0397 101 µM -0.166084664919535 0.440601081681637 no 1920 0.434045161084379 2718 27816 SGTC_3124 9127567 49.47 µM -0.166131052768027 0.440581279013532 no 1921 0.434026908565426 2885 17592030 SGTC_2389 9091542 195.52 µM -0.16713453963644 0.440152933513765 no 1922 0.43363209476439 2764 3626624 YOL127W RPL25 SGTC_275 trichlorophene 5.69 µM -0.16713915606835 0.440150963118456 no 1923 0.433630278619256 2796 62616 SGTC_2286 7945697 125 µM -0.16739568744538 0.440041472180253 no 1924 0.433529359110745 2775 1245733 SGTC_1678 st019265 80.2 µM -0.168503715978722 0.439568603925707 no 1925 0.433093510271167 2898 5367020 SGTC_2630 antimycin a 100 µM -0.169411693081329 0.439181174937251 no 1926 0.432736413346944 2659 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_3211 9128781 49.47 µM -0.170108309675269 0.438883971822396 no 1927 0.43246247929335 2847 17194361 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.170251747640457 0.438822780006982 no 1928 0.432406078485145 2705 15053 SGTC_2308 7584454 197.62 µM -0.170829063449751 0.438576507136146 no 1929 0.432179087822043 2830 893577 SGTC_2158 5657123 3.6195 µM -0.172130493628243 0.438021427056457 no 1930 0.431667470044957 2682 2858827 SGTC_3255 9139072 49.47 µM -0.174401798607868 0.437052973095287 no 1931 0.430774850448965 2776 17646060 SGTC_2788 5282734 71.43 µM -0.175256475815245 0.436688647535038 no 1932 0.430439054833995 2853 743706 SGTC_89 0302-0250 142.109 µM -0.175374550294863 0.436638319822378 no 1933 0.430392668294955 2683 4203518 YLR208W SEC13 SGTC_2415 st077333 57.7 µM -0.176366643870357 0.436215493416333 no 1934 0.430002954104075 2902 2766255 SGTC_1040 k898-0338 155 µM -0.177042265774896 0.435927587686618 no 1935 0.429737595317216 2889 20969351 SGTC_1935 st074532 41.6 µM -0.177790475256082 0.435608789516661 no 1936 0.429443763911247 2856 2829742 SGTC_913 3487-1245 167 µM -0.178390057725709 0.435353348745724 no 1937 0.429208328430267 2690 4016153 SGTC_327 1273-0057 3.96 µM -0.178413559117303 0.435343336970985 no 1938 0.429199100751765 2784 3108138 SGTC_2402 5553605 200 µM -0.178897571349167 0.435137153239298 no 1939 0.429009064903262 2901 6758546 SGTC_175 3793-3120 23.7 µM -0.179084186120608 0.435057662166476 no 1940 0.428935799460796 2748 5322297 SGTC_2646 retinol 96.75 µM -0.179590739277754 0.43484190227404 no 1941 0.428736937730258 2802 445354 A vitamin A analog and teratogen. SGTC_2627 acetyl isogambogic acid 100 µM -0.179649354855425 0.434816936963403 no 1942 0.428713927698648 2828 6857789 A caspase activator and apoptosis inducer. SGTC_1762 st045503 25.4615 µM -0.180357885710314 0.434515182942475 no 1943 0.42843580721821 2781 4645554 SGTC_38 0929-0051 58.268 µM -0.180639818024675 0.434395122257894 no 1944 0.428325149859578 2838 1379719 SGTC_1303 1160-0052 261 µM -0.181425560055086 0.434060546511602 no 1945 0.428016778873735 2751 3562476 SGTC_80 0159-0065 512.242 µM -0.181595483464141 0.433988197859171 no 1946 0.42795009679505 2686 1548079 SGTC_2211 7117706 200 µM -0.18307742653188 0.43335732179472 no 1947 0.427368633716657 2794 822771 SGTC_1245 0418-0076 17.2 µM -0.183339116876666 0.433245935528152 no 1948 0.42726597184965 2911 6790114 SGTC_1463 k081-0032 34.1 µM -0.18411064995529 0.432917569938717 no 1949 0.42696332592005 2796 977755 SGTC_2223 6903751 107.57 µM -0.184754484041486 0.43264358866425 no 1950 0.426710804815649 2832 5598863 SGTC_2057 5236571 38.335 µM -0.184958840703065 0.432556632187346 no 1951 0.426630659432029 2855 54684039 YBR257W POP4 SGTC_1015 4130-4525 82 µM -0.185848819465703 0.43217797253058 no 1952 0.426281659493851 2746 1363237 SGTC_2318 6029776 164 µM -0.186930735627009 0.43171773310724 no 1953 0.425857470194385 2890 818325 SGTC_259 usnic acid 108.925 µM -0.186994335905628 0.431690680879919 no 1954 0.425832536955135 2913 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2880 9042983 58.44 µM -0.187471273548698 0.431487826804455 no 1955 0.425645572381876 2877 6464714 SGTC_2757 clomiphene 4.22 µM -0.188061314402245 0.431236891978325 no 1956 0.425414293297207 2917 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1255 0566-0045 221 µM -0.188615656814682 0.431001164403801 no 1957 0.425197030355993 2881 2788469 SGTC_497 capsazepine 133 µM -0.188673298763904 0.430976654253849 no 1958 0.425174440099496 2751 2733484 A calcium channel blocker. SGTC_2116 5511452 16.8835 µM -0.189022072578617 0.430828356502579 no 1959 0.42503775860596 2859 870744 SGTC_1193 1488-0126 41.5 µM -0.191584363439078 0.429739177202254 no 1960 0.424033895893382 2760 1384710 SGTC_2261 9010538 184.68 µM -0.191912575586138 0.429599699140707 no 1961 0.423905343324915 2876 6457250 SGTC_3314 9135860 59.4275 µM -0.1927034194329 0.429263655791685 no 1962 0.423595622664879 2773 25252478 SGTC_51 1013-0126 23.419 µM -0.193056522438489 0.429113632701008 no 1963 0.423457351055448 2965 1627850 SGTC_1987 st072290 61.9 µM -0.193067969817335 0.429108769217372 no 1964 0.423452868533901 2802 54697379 SGTC_1014 4130-3005 69.3 µM -0.193242871948645 0.429034462396656 no 1965 0.423384382247611 2738 743608 SGTC_2309 7664088 163.95 µM -0.193521304370618 0.428916176128557 no 1966 0.423275361465285 2855 704922 SGTC_3012 9080433 71.4286 µM -0.194053271027355 0.428690198831984 no 1967 0.423067085176221 2811 17688859 SGTC_653 0203-0016 55.2 µM -0.195205174627805 0.428200955020859 no 1968 0.422616164110323 2814 295302 SGTC_3291 9121177 71.43 µM -0.195325880763 0.428149694318891 no 1969 0.422568918671805 2778 17015612 SGTC_816 0325-0417 81.3 µM -0.195395446030062 0.428120152341201 no 1970 0.422541690722914 2808 68101 SGTC_3258 9138477 49.47 µM -0.196047881573299 0.427843105022056 no 1971 0.422286344511817 2773 4970355 SGTC_2339 9000433 200 µM -0.196788487419352 0.427528660570997 no 1972 0.421996530332873 2822 2988954 SGTC_2533 agelasine 13.65 µM -0.197365779410555 0.42728358739274 no 1973 0.42177065348173 2914 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2196 6573537 42.6665 µM -0.198208557073685 0.426925860101074 no 1974 0.421440946365168 2844 2903087 SGTC_383 2324-0395 7.37 µM -0.200071502611028 0.426135323699999 no 1975 0.420712330187203 2890 3146421 SGTC_113 0099-0221 2.5 µM -0.200749731499258 0.425847592433839 no 1976 0.420447135542438 2908 89219 SGTC_2264 7948757 110.76 µM -0.200869876071103 0.425796626511006 no 1977 0.420400161509395 2739 2971411 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.203260874025152 0.424782612223487 no 1978 0.41946556757313 2866 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_332 4112-0506 40.9 µM -0.203700040420707 0.424596417100761 no 1979 0.419293955303598 2774 2790355 SGTC_2848 9016370 25.97 µM -0.205419500592629 0.423867573001695 no 1980 0.418622192930909 2806 7894410 SGTC_2203 7227154 166.4 µM -0.205690123578475 0.423752885086286 no 1981 0.418516486923095 2772 896304 SGTC_3340 9146634 11.102 µM -0.20600997571739 0.42361734256698 no 1982 0.41839155947365 2848 4907387 SGTC_2121 5257820 149.641 µM -0.206557963378833 0.423385144941985 no 1983 0.418177546275258 2912 791256 SGTC_1567 st069303 68.4 µM -0.20837220454517 0.422616590742839 no 1984 0.417469178777168 2886 5581319 SGTC_2669 eugenol 100 µM -0.20866996540049 0.422490480464918 no 1985 0.417352944055744 2821 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1376 2910-0861 41.3 µM -0.209114469130538 0.422302235149179 no 1986 0.417179439834993 2770 1112859 SGTC_468 gf-109203x 121 µM -0.209901844884846 0.421968828670424 no 1987 0.416872141148704 2868 2396 A protein kinase C inhibitor. SGTC_2997 9067075 71.4286 µM -0.210051240819291 0.42190557474314 no 1988 0.416813840311624 2884 27209819 SGTC_1868 st057644 42.7 µM -0.211565646687396 0.421264492445778 no 1989 0.416222956294123 2762 688665 SGTC_761 k216-0224 480 µM -0.211949654358214 0.421101966401956 no 1990 0.41607315595452 2934 1340404 SGTC_167 3672-0051 66.205 µM -0.212553774526322 0.420846307947656 no 1991 0.415837515018451 2743 3237971 SGTC_2739 tacrine 100.86 µM -0.213070403959384 0.420627701292153 no 1992 0.415636024400932 2875 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1363 1636-0063 10.4 µM -0.213469586601884 0.420458807847665 no 1993 0.415480354386027 2783 6072185 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.213580860683229 0.420411730596212 no 1994 0.415436962983853 2888 616764 SGTC_1372 2752-0194 270 µM -0.214710943515688 0.41993368571615 no 1995 0.414996344936489 2767 823334 SGTC_1642 st009582 77.7 µM -0.215744452018755 0.419496596853904 no 1996 0.414593474686434 2917 6739311 SGTC_1038 k292-0204 154 µM -0.216389667860761 0.419223774081817 no 1997 0.414342009674413 2762 4454212 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.216460493540612 0.419193828546635 no 1998 0.414314408365292 2893 7104 SGTC_151 3013-0144 2.285 µM -0.219125245688783 0.418067496467345 no 1999 0.413276242703968 3012 906558 YHR107C CDC12 SGTC_1042 0350-0096 82 µM -0.219378309549041 0.417960566719896 no 2000 0.413177682490837 2763 3122515 SGTC_63 0099-0242 26.702 µM -0.220196212524799 0.417615011044114 no 2001 0.412859173106662 2939 3898502 YLR359W ADE13 SGTC_7 0192-1582 4.227 µM -0.22044919439878 0.41750814164678 no 2002 0.41276066801299 2820 252616 SGTC_3287 9117173 37.0625 µM -0.22123407922332 0.417176614535293 no 2003 0.41245508761431 2850 2789709 SGTC_2617 dihydrotanshinone i 20.83 µM -0.221318842289024 0.417140815024501 no 2004 0.412422089852592 2800 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2129 girgensonine 121.053 µM -0.221383718141692 0.417113415302334 no 2005 0.412396834483848 2869 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1260 0700-1617 7.75 µM -0.221665030723648 0.416994610168821 no 2006 0.412287327165438 2904 2853078 SGTC_493 zm226600 134 µM -0.222689419287762 0.416562050137545 no 2007 0.411888618393163 2987 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3026 9090633 49.47 µM -0.222923852877388 0.416463072002638 no 2008 0.411797385781794 2788 25236842 SGTC_2733 amorolfine 100 µM -0.2232338346631 0.416332205464022 no 2009 0.411676760014852 2824 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3105 9121040 49.47 µM -0.224172374860728 0.415936033929201 no 2010 0.411311589072455 2724 41448907 SGTC_2897 9048598 12.99 µM -0.224912538267348 0.415623660355594 no 2011 0.41102365752504 2820 6467404 SGTC_2012 4023501 200 µM -0.225464359499194 0.415390808121353 no 2012 0.410809024292887 2892 3477460 SGTC_2120 5538279 151.968 µM -0.226597480464938 0.414912757827126 no 2013 0.410368375817841 2836 2058197 SGTC_1860 st056228 74.6 µM -0.226941148667585 0.414767793152848 no 2014 0.410234752341625 2919 688679 SGTC_2154 5570129 200 µM -0.227788560679854 0.414410391017488 no 2015 0.409905310094803 2790 673366 SGTC_1287 0971-0001 34.6 µM -0.228119451488992 0.414270854647851 no 2016 0.409776689314525 2816 4665869 SGTC_1205 4161-2785 76 µM -0.228339920954722 0.41417788886896 no 2017 0.409690995874411 2939 3498106 SGTC_1332 1480-0653 17.5 µM -0.228549482823601 0.414089526974562 no 2018 0.409609546065678 2907 5749438 SGTC_2166 5933061 31.504 µM -0.229146497122591 0.413837819374608 no 2019 0.409377527633866 3322 2877375 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.229281857486373 0.413780754919284 no 2020 0.409324926773315 2895 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2285 7945142 200 µM -0.234701640051954 0.41149742201193 no 2021 0.407220157356148 2941 2970608 SGTC_1766 st045414 44.774 µM -0.234873337655108 0.411425135018348 no 2022 0.407153522107836 2810 253960 SGTC_2507 purpurin 79.67 µM -0.235275026012895 0.411256030582239 no 2023 0.406997638740312 2807 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1229 0139-0193 12.2 µM -0.235375574375373 0.411213703893066 no 2024 0.406958621199931 2941 3090752 SGTC_1233 0325-0408 14.2 µM -0.235548219953383 0.411141029678299 no 2025 0.406891628669694 2914 12874 SGTC_832 4083-0019 164 µM -0.236569236343284 0.410711300819895 no 2026 0.406495494314288 2947 1990758 SGTC_1034 k072-0165 12.7 µM -0.238538864862329 0.409882620016154 no 2027 0.405731587672007 2998 5835461 SGTC_1430 4049-0248 69.1 µM -0.238792033396659 0.409776133652172 no 2028 0.405633423993282 2936 22774488 SGTC_1824 st053723 68.6 µM -0.240112766491985 0.409220722204526 no 2029 0.405121418727854 2864 675225 SGTC_496 calpeptin 138 µM -0.243223339718875 0.407913346174635 no 2030 0.403916193585308 2898 73364 A calpain inhibitor. SGTC_107 0358-0022 2.6945 µM -0.243396935363034 0.407840413862701 no 2031 0.403848958832767 2901 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1436 4092-1007 8.32 µM -0.243495546688618 0.407798985950599 no 2032 0.403810767272751 2859 2881121 SGTC_1074 carmofur 3.8 µM -0.244364348241018 0.407434035618539 no 2033 0.40347432544369 2847 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_871 0574-0004 149 µM -0.246123974393341 0.406695130330685 no 2034 0.402793132460395 2845 9551173 SGTC_747 3448-8087 38.7 µM -0.246427823757445 0.406567570922276 no 2035 0.402675534978859 2897 5168703 SGTC_2902 5787006 60.46 µM -0.247725460048763 0.406022920226463 no 2036 0.402173415740332 2840 591003 SGTC_2088 5278280 127.392 µM -0.248161364064107 0.405840001059236 no 2037 0.402004779231643 2928 791502 SGTC_888 0916-0002 6.97 µM -0.249729317468859 0.405182208245269 no 2038 0.401398342161795 3017 2802138 YIL048W NEO1 SGTC_1626 st003712 1.76 µM -0.249782992090682 0.405159695226229 no 2039 0.401377586632229 3010 24207035 SGTC_783 0848-0141 92.7 µM -0.250219319377473 0.40497669590919 no 2040 0.401208872831938 2823 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2417 cerulenin 830 nM -0.250228744898936 0.404972742995702 no 2041 0.401205228487513 2898 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1250 0485-0349 40.2 µM -0.250797795439799 0.404734110245268 no 2042 0.400985223050646 2882 6842794 YDL195W SEC31 SGTC_2320 7373003 200 µM -0.251800917907194 0.404313534680873 no 2043 0.400597473894495 2895 5415828 SGTC_3320 9137005 35.139 µM -0.251979221230167 0.404238789643594 no 2044 0.400528562377199 2894 4908713 SGTC_1921 5740136 50 µM -0.252240332418826 0.404129337725246 no 2045 0.40042765246896 3057 1774243 SGTC_1878 temozolomide 1 mM -0.253465806095336 0.403615747208228 no 2046 0.399954140687555 2926 5394 DNA alkylating agent. SGTC_1085 doxorubicin 7.67 µM -0.253899042623654 0.403434219431957 no 2047 0.399786777218812 2947 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_625 k213-0058 121 µM -0.255013685615079 0.40296727542336 no 2048 0.3993562645105 2911 3655420 SGTC_3128 9127691 49.47 µM -0.255350584021999 0.402826169814509 no 2049 0.399226167042528 3003 41316314 SGTC_217 ketoconazole 989 nM -0.255512738226217 0.402758258100932 no 2050 0.399163553188786 2938 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2215 7188065 200 µM -0.256123465226306 0.402502506209945 no 2051 0.398927751758764 2988 940217 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.256429824642827 0.402374228915582 no 2052 0.398809480406457 2986 521171 SGTC_925 2064-1272 59.6 µM -0.257664187079218 0.40185748944009 no 2053 0.398333043789739 2882 6815817 SGTC_2540 epiandrosterone 100 µM -0.258029636137333 0.401704534863378 no 2054 0.398192017568364 2885 441302 A steroid. SGTC_1409 3909-8004 61.9 µM -0.258562289333328 0.401481625854248 no 2055 0.397986491351497 2894 2119279 SGTC_576 1073-0113 22.7 µM -0.258890137384431 0.401344441287768 no 2056 0.397860004029966 2909 5439563 SGTC_1248 0469-0687 58.6 µM -0.259964804269788 0.400894843584747 no 2057 0.397445461268155 2968 4017482 SGTC_2963 9082507 9 µM -0.260084457747233 0.400844793457068 no 2058 0.397399313207414 3029 16459611 SGTC_801 0866-0028 10.1 µM -0.261369719217144 0.400307281283594 no 2059 0.396903703096716 2838 6849771 SGTC_524 r073-0010 27.8 µM -0.261382702494433 0.400301852478553 no 2060 0.396898697458742 2856 2772106 SGTC_1998 st075797 76.8 µM -0.261576620956535 0.400220770042289 no 2061 0.396823935182395 2955 24208315 SGTC_394 menadione 8.33 µM -0.26188056538822 0.400093691493286 no 2062 0.396706761719094 3002 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1163 k060-0048 49.9 µM -0.262492723133674 0.399837781704434 no 2063 0.396470797415566 2876 6809982 SGTC_2741 miltefosine 3.04 µM -0.263055353084339 0.39960261471924 no 2064 0.396253957690221 2877 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1891 st059073 26.2 µM -0.264104697841947 0.399164108975253 no 2065 0.395849622013001 3077 688754 SGTC_3096 9117468 49.47 µM -0.264132571998901 0.399152462506969 no 2066 0.395838883011382 3008 41316311 SGTC_1321 1326-2144 215 µM -0.265168838798529 0.398719550027084 no 2067 0.395439699457654 2995 3513030 SGTC_2566 crystal violet carbinol 226 nM -0.26550886054117 0.398577529117966 no 2068 0.395308742503591 3033 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1651 st011928 86.1 µM -0.266794346891174 0.398040726322871 no 2069 0.394813753536827 2987 720198 SGTC_288 1315-0019 35.1 µM -0.267048836425907 0.397934477568029 no 2070 0.39471577998034 2959 6811474 SGTC_338 4055-0136 114 µM -0.267050402633456 0.397933823703655 no 2071 0.394715177041287 2877 2900563 SGTC_3045 9092950 49.47 µM -0.267443290011016 0.397769809126764 no 2072 0.39456393612733 2991 44120432 SGTC_199 4063-0024 41.6 µM -0.268905595021343 0.397159514961665 no 2073 0.394001165652731 2996 306215 SGTC_730 1436-0052 41.2 µM -0.268918185435969 0.397154261432949 no 2074 0.393996321170151 2876 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1710 st031758 61.5 µM -0.269750208753202 0.396807129333227 no 2075 0.39367621540697 3036 5394341 SGTC_1689 st020265 53.493 µM -0.270528514145865 0.3964824831268 no 2076 0.393376841658162 3016 5758320 YPR016C TIF6 SGTC_1139 k015-0024 46.9 µM -0.27093494634272 0.396312980914815 no 2077 0.393220533294985 3004 2766652 SGTC_2356 9061756 188.97 µM -0.271262774652525 0.396176274666104 no 2078 0.393094467469857 2959 20104043 SGTC_1635 st007035 42.4 µM -0.271380973679903 0.396126988137343 no 2079 0.393049016981619 2923 3716403 SGTC_2628 lathosterol 100 µM -0.272587331049889 0.395624057356187 no 2080 0.392585225813988 3036 6710616 SGTC_510 ag-490 170 µM -0.273153837047802 0.39538794072448 no 2081 0.392367481839277 2958 5328779 SGTC_3125 9127534 49.47 µM -0.273660543347837 0.395176780811857 no 2082 0.392172751201881 2921 1639235 SGTC_1485 3909-9022 254 µM -0.275300971905937 0.394493375795916 no 2083 0.391542508918304 2908 714516 SGTC_3218 9131285 49.47 µM -0.275646279397429 0.39434956145903 no 2084 0.391409880164192 3059 17156417 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.275698682021674 0.394327737970038 no 2085 0.391389754003828 2909 390807 SGTC_2063 5246145 200 µM -0.276603362143712 0.393951029101084 no 2086 0.391042341388499 3018 711240 SGTC_2250 alverine citrate 130 µM -0.276841810173528 0.393851755829332 no 2087 0.390950787737331 2843 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1473 k844-0725 134 µM -0.277084714813596 0.393750634225454 no 2088 0.390857529156049 2928 54682906 SGTC_2921 7974240 10.71 µM -0.278619861004749 0.393111716306958 no 2089 0.390268284588061 3025 2979074 YDR527W RBA50 SGTC_2985 9022375 71.43 µM -0.278706867504199 0.393075513366769 no 2090 0.390234895883587 3094 4939335 SGTC_3308 9128332 17.569 µM -0.279658356275707 0.39267966438237 no 2091 0.389869815392623 3060 17332805 YDL196W YDL196W SGTC_2996 9066192 71.4286 µM -0.280185819675171 0.392460270957794 no 2092 0.389667472702353 2940 6472854 SGTC_2809 7964133 12.99 µM -0.280198686473139 0.392454919561258 no 2093 0.389662537183474 2937 1253665 SGTC_3030 9087619 49.47 µM -0.281042886736818 0.392103854902372 no 2094 0.389338753006886 2949 25236973 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.282014109264323 0.391700076073505 no 2095 0.388966345799691 2917 2724278 An inhibitor of dopamine biosynthesis. SGTC_1669 st015249 58.4 µM -0.28210754651953 0.391661236345603 no 2096 0.388930523433406 2995 722793 SGTC_1168 k815-0004 80.5 µM -0.282856678045322 0.391349878587359 no 2097 0.388643352408649 2887 642433 SGTC_1322 1348-1070 12 µM -0.283609083143641 0.391037230310883 no 2098 0.388354987741009 2986 6758089 SGTC_2015 5119600 184 µM -0.284091874700146 0.3908366521158 no 2099 0.388169986800084 3095 2828786 SGTC_2189 6047310 154.431 µM -0.284115748353033 0.390826734438953 no 2100 0.388160839310858 2876 711535 SGTC_3315 9136395 68.55 µM -0.286939596677961 0.389654144073914 no 2101 0.387079285474377 3092 16876844 SGTC_1243 0416-0003 5.65 µM -0.288250246039452 0.389110243190358 no 2102 0.386577594685792 2948 2141977 SGTC_3241 9133421 49.47 µM -0.288861179134061 0.388856788785819 no 2103 0.386343806222232 2955 17018221 SGTC_1156 4092-0367 4.88 µM -0.289382078760443 0.388640723414532 no 2104 0.386144503842865 2938 1357585 SGTC_738 1315-0003 72.4 µM -0.290192181453606 0.388304767182711 no 2105 0.385834608643836 3078 6251474 SGTC_1550 gossypolone 36.6 µM -0.291803724804014 0.387636695592622 no 2106 0.385218348574488 2917 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_982 1491-0518 27.5 µM -0.291991505440608 0.387558871990026 no 2107 0.385146559391387 2917 3091256 SGTC_3252 9135871 49.47 µM -0.29340489405099 0.386973253925715 no 2108 0.384606342536248 3069 17682838 SGTC_361 000s-0510 1.45 µM -0.293471194321833 0.386945789628856 no 2109 0.384581007139319 3013 660 SGTC_746 1095-0025 46.6 µM -0.293752363522056 0.386829324083202 no 2110 0.38447356911648 3104 6749286 SGTC_2027 5150920 200 µM -0.294206952910757 0.386641046209983 no 2111 0.384299883995845 2980 786715 SGTC_2829 7992743 58.44 µM -0.294860106035832 0.386370575652664 no 2112 0.38405037423224 3098 16462845 SGTC_670 4204-0025 119 µM -0.295556135730629 0.386082410674646 no 2113 0.383784538158304 3032 719039 SGTC_1313 1220-0047 237 µM -0.296439743313491 0.38571667664665 no 2114 0.383447138856657 2980 3528706 SGTC_1106 tegaserod maleate 11.7 µM -0.296520086662881 0.385683426762739 no 2115 0.383416464696398 2971 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2210 7115885 190.385 µM -0.296720278426983 0.385600581582059 no 2116 0.383340036978766 2949 2927039 SGTC_57 miconazole 162.5 nM -0.297954291684411 0.385090026333476 no 2117 0.382869024952916 2892 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2101 5377231 179.231 µM -0.298397082933912 0.384906876319491 no 2118 0.382700057598353 3069 2844213 SGTC_3189 9110682 49.47 µM -0.298513821982532 0.384858594278591 no 2119 0.382655514165698 3046 17122418 SGTC_2707 st078556 66.6 µM -0.299125235943698 0.384605749083995 no 2120 0.382422245901185 3004 17250899 SGTC_673 1082-0474 110 µM -0.299130112599023 0.384603732580603 no 2121 0.382420385518177 2971 3098046 SGTC_2565 isoliquiritigenin 100 µM -0.299734707477997 0.384353756007296 no 2122 0.38218976117171 3061 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_720 r052-1644 49.9 µM -0.301429791012723 0.383653161315527 no 2123 0.381543390059955 3057 1422863 YOR257W CDC31 SGTC_2658 polymyxin b sulfate 77.05 µM -0.303624998423853 0.382746425748066 no 2124 0.380706802084585 2967 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2299 7976368 114.88 µM -0.305261186143836 0.382071012041567 no 2125 0.380083617460822 3085 2979718 SGTC_1326 1431-2094 10.8 µM -0.306552421446865 0.381538246869931 no 2126 0.379592036545235 2889 616278 SGTC_2460 5552655 174.22 µM -0.306788725813078 0.38144077167377 no 2127 0.379502095112981 3076 5401989 SGTC_1495 4469-0029 237 µM -0.30680828527838 0.381432703760588 no 2128 0.379494650742302 2937 793680 SGTC_441 propafenone 146 µM -0.308301547226953 0.380816913523279 no 2129 0.378926444416325 2921 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2864 9034755 47.6 µM -0.308715151093125 0.380646405174529 no 2130 0.378769108764913 2936 4930451 SGTC_362 0310-0100 9.03 µM -0.309528007533976 0.380311372376491 no 2131 0.378459955276158 3077 790235 SGTC_834 0312-0008 75.7 µM -0.310310669442949 0.379988869601183 no 2132 0.378162359158022 2949 6385573 YIL048W NEO1 SGTC_1621 st003705 32.4 µM -0.310779401862368 0.37979576418705 no 2133 0.377984164877216 3099 24207032 SGTC_2157 5649910 96.377 µM -0.311664137115086 0.379431358268163 no 2134 0.377647892864796 2951 2858091 SGTC_1269 0831-0796 3.05 µM -0.311955574246938 0.379311344189776 no 2135 0.377537143122513 3082 927758 SGTC_2314 7727897 200 µM -0.314735225109349 0.378167267381799 no 2136 0.376481348333859 2953 900724 SGTC_1403 3909-7815 62.9 µM -0.315522443513423 0.377843449599325 no 2137 0.376182506611356 2936 6615483 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.315574398708338 0.377822081143858 no 2138 0.376162786129681 2906 688667 SGTC_1767 st044992 70.3 µM -0.31586513768796 0.377702511110771 no 2139 0.376052437152366 3010 9600693 SGTC_2481 5478948 45.16 µM -0.315914281542299 0.377682301244933 no 2140 0.376033785772846 3113 77792 SGTC_680 0417-1641 114 µM -0.316051547319534 0.377625853988232 no 2141 0.375981691350241 2931 2835990 SGTC_598 3937-0236 20.2 µM -0.320118735504566 0.375954511285104 no 2142 0.374439161750985 3039 1379313 SGTC_2611 pyromycin 23.93 µM -0.321387754165171 0.375433503620808 no 2143 0.373958281030431 2992 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2435 5706476 10.6 µM -0.323410611501625 0.374603470215502 no 2144 0.373192147090034 3120 5725375 SGTC_2311 7694451 200 µM -0.324386372591396 0.374203296255813 no 2145 0.372822767769086 3013 2163142 SGTC_177 1327-0068 8.361 µM -0.325025160597683 0.373941393271854 no 2146 0.372581014616499 3068 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1197 1601-0112 267 µM -0.325269765346668 0.373841120761878 no 2147 0.372488455765743 2968 7350313 SGTC_421 streptovitacin 30 mM -0.325516717884253 0.373739894467684 no 2148 0.37239501597811 3148 91467 include heat shock SGTC_2774 tamoxifen 10.92 µM -0.326543543904609 0.373319090075814 no 2149 0.372006574938422 2963 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2007 4011539 71.82 µM -0.326698234772613 0.37325570916633 no 2150 0.371948067752164 2959 45595301 SGTC_1361 1608-0041 5.61 µM -0.326814211460923 0.373208192721789 no 2151 0.371904204983778 2995 X1361 SGTC_904 1141-0088 396 µM -0.327262419780062 0.373024576831416 no 2152 0.371734706742336 3024 1378119 SGTC_1942 st076330 65.2 µM -0.329928586164706 0.37193293533514 no 2153 0.370726961572529 3132 24208414 SGTC_3263 9137018 49.47 µM -0.329981778969407 0.371911166384866 no 2154 0.370706864997728 3034 43844957 SGTC_1387 3342-1166 1.8 µM -0.330444656385568 0.371721752878333 no 2155 0.370532001906238 3036 3418228 SGTC_106 0092-0003 11.579 µM -0.330970792966665 0.37150649087151 no 2156 0.370333273620015 3040 1072148 SGTC_1259 0671-0132 43 µM -0.331084126292224 0.371460127258043 no 2157 0.37029047075084 3011 X1259 SGTC_563 tetrahydrosecaminediol 614 µM -0.331522845525638 0.371280668871916 no 2158 0.370124793750991 3136 334274 A psychoactive constituent of the cannabis plant. SGTC_1256 0570-0116 285 µM -0.33165680119946 0.371225879791348 no 2159 0.370074211815143 3015 410638 SGTC_813 k007-0158 173 µM -0.331994066356366 0.371087946854615 no 2160 0.369946869756617 3041 6523916 SGTC_2453 5731132 22.18 µM -0.332123548173991 0.371034996457365 no 2161 0.369897984766085 3145 1362040 SGTC_1314 1222-0010 41.1 µM -0.334084042215085 0.37023356935717 no 2162 0.369158070711148 3048 3526027 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.335260531368361 0.369752904385684 no 2163 0.368714281972896 2996 641818 YHR062C RPP1 SGTC_2246 7293507 91.5585 µM -0.337735826532691 0.368742265892106 no 2164 0.367781136923461 3152 887656 SGTC_1373 2887-0003 58.5 µM -0.337798134764669 0.368716837733282 no 2165 0.367757657797919 3058 776948 SGTC_3279 9140807 49.47 µM -0.337890200152775 0.368679266650249 no 2166 0.367722966419671 3014 45595718 SGTC_2321 7390090 138.78 µM -0.33809781676441 0.368594544726679 no 2167 0.367644737870806 3054 649046 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.339748231309046 0.36792128905279 no 2168 0.367023068288932 2969 5355888 SGTC_1392 3455-1037 33.9 µM -0.342072909876901 0.366973668302982 no 2169 0.366148011910041 3160 981132 SGTC_3188 9110789 49.47 µM -0.342514241672885 0.366793857244537 no 2170 0.365981964063661 3187 849217 SGTC_11 0438-0307 1.3 µM -0.343900091327936 0.366229413026476 no 2171 0.365460711591162 3112 4011476 SGTC_1358 1509-0022 2.48 µM -0.345153815962404 0.365719031353821 no 2172 0.364989368572897 3080 3258434 SGTC_1468 k284-1086 134 µM -0.345939150416405 0.365399448698676 no 2173 0.364694222634264 3038 15996457 SGTC_1574 spiramycin 23.7 µM -0.346188922817813 0.365297826318832 no 2174 0.364600369476009 2963 6419898 An antibiotic and protein synthesis inhibitor. SGTC_864 0469-0573 172 µM -0.347928398779513 0.364590365890631 no 2175 0.363946978509116 3011 689425 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.348255028453593 0.364457574010647 no 2176 0.363824332212401 3030 689007 SGTC_2313 7726885 200 µM -0.349935240354473 0.363774738198256 no 2177 0.363193649531615 3108 726423 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.350275036977201 0.363636697815617 no 2178 0.36306614882219 2933 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1857 st056007 79.3 µM -0.350485033417937 0.363551396843215 no 2179 0.362987360171292 3106 619834 SGTC_3192 9110362 49.47 µM -0.350888438814852 0.363387551748784 no 2180 0.362836022606312 3021 16649480 SGTC_566 0958-0068 16.5 µM -0.351108766139858 0.363298075266965 no 2181 0.362753375836803 3188 6815365 SGTC_1215 3852-0577 11.2 µM -0.351322549313771 0.363211263540721 no 2182 0.362673189948636 3187 2884876 SGTC_311 1315-0136 58 µM -0.352448484005435 0.362754167111489 no 2183 0.362250973320636 3199 6759207 SGTC_1613 st002381 52.1 µM -0.352531005930122 0.362720673314585 no 2184 0.362220034832852 3075 551167 SGTC_1398 3558-0053 112 µM -0.352884578612143 0.362577177993578 no 2185 0.362087486263432 2953 4532369 SGTC_1458 k015-0034 6.33 µM -0.353960432870082 0.36214066788119 no 2186 0.361684268015159 3075 3598957 SGTC_235 0330-0087 5 mM -0.354115700106085 0.362077685548685 no 2187 0.361626088243679 3061 46494818 YHR062C RPP1 SGTC_3295 9122362 53.5725 µM -0.35454162272919 0.361904934210827 no 2188 0.361466508341019 3113 4730473 SGTC_1479 0549-0158 134 µM -0.354666872842617 0.361854138962565 no 2189 0.361419585619498 3074 5440202 SGTC_1388 3346-4487 254 µM -0.354934308051242 0.36174568862213 no 2190 0.361319402765027 3106 3345614 SGTC_2384 9036245 200 µM -0.35646014181694 0.361127145054834 no 2191 0.360747998247752 3068 6462766 SGTC_2766 oltipraz 83.91 µM -0.357367541581147 0.360759474682216 no 2192 0.36040833631788 3173 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1696 st025591 34.7925 µM -0.359433012707764 0.359923044224403 no 2193 0.359635590970296 3044 2787147 SGTC_211 3455-0679 143.504 µM -0.362269518560033 0.358775469521576 no 2194 0.358575317020182 3127 748649 SGTC_2952 9073731 13.78 µM -0.362540142140087 0.358666048825341 no 2195 0.358474215851518 3063 16457353 SGTC_3288 9119690 36.221 µM -0.363030862472037 0.358467666437622 no 2196 0.358290914931402 3076 17595618 YKL019W RAM2 SGTC_2461 5755302 26.15 µM -0.36449579717172 0.357875667991073 no 2197 0.357743905821814 3182 2788904 SGTC_469 w7 172 µM -0.365248742480795 0.357571526204017 no 2198 0.357462868310084 3092 45115570 A P450 inhibitor. SGTC_3071 9117417 49.47 µM -0.366562296917158 0.357041150733298 no 2199 0.356972768025848 3068 45595590 YGL055W OLE1 SGTC_2971 9092186 9.93 µM -0.366934580282871 0.356890883605689 no 2200 0.356833908258861 3009 25236400 SGTC_3300 9124615 50.48 µM -0.369982889804962 0.355661311877867 no 2201 0.355697619594035 3238 24824903 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.371078960671596 0.355219564770332 no 2202 0.355289360517216 3046 364106 SGTC_1565 sinapyl alcohol 95.1 µM -0.371400947904475 0.355089831873812 no 2203 0.355169459828446 3147 5280507 A phenol propionate derived from cinnamic acid. SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.372082173266232 0.354815412580176 no 2204 0.354915834337136 3307 6728940 SGTC_1798 st045719 60.953 µM -0.372173758725439 0.354778524777702 no 2205 0.354881741259161 3155 3980186 SGTC_2409 alverine citrate 63.97 µM -0.373631483017626 0.354191581833876 no 2206 0.35433925378127 3287 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3089 9117425 49.47 µM -0.373970604406894 0.354055086462539 no 2207 0.35421309314623 3121 9401657 SGTC_2634 4'-methoxyflavone 100 µM -0.376878583878539 0.352885404638528 no 2208 0.353131918752936 3126 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2059 5238311 157 µM -0.377728208407165 0.352543920342636 no 2209 0.352816255170009 3018 703021 SGTC_969 1313-0238 134 µM -0.377959953641162 0.352450797034291 no 2210 0.352730171732539 3055 5212874 SGTC_2456 5770359 74.46 µM -0.378117507576501 0.352387491423914 no 2211 0.352671651492895 3224 3118787 SGTC_2725 haloperidol 53.21 µM -0.380311131362497 0.351506512774598 no 2212 0.351857236791704 3046 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1700 st030840 7.9285 µM -0.381460786711799 0.351045119052821 no 2213 0.351430681566587 3173 5499307 SGTC_1298 1079-1278 263 µM -0.381846771231865 0.350890260220048 no 2214 0.351287512112375 3117 2840950 SGTC_1411 3909-8223 150 µM -0.381935387414735 0.350854710478947 no 2215 0.351254645557876 3167 X1411 SGTC_356 1634-0012 32.5 µM -0.385931469750181 0.349252981929423 no 2216 0.34977371162311 3202 735457 SGTC_2249 haloperidol 116.36 µM -0.386183594989694 0.34915201353116 no 2217 0.349680351229722 3075 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2447 5741742 33.78 µM -0.387182578939333 0.348752056229702 no 2218 0.349310523153552 3179 1776504 SGTC_852 0418-0143 439 µM -0.388631140873619 0.348172402600016 no 2219 0.348774513538003 3196 5369229 SGTC_2869 9037858 32.47 µM -0.390668419947103 0.347357769228015 no 2220 0.34802117233239 3046 27187042 SGTC_2980 9014342 25.29 µM -0.391174274189538 0.347155605673464 no 2221 0.347834211287824 3237 2996599 SGTC_1849 st056239 19.2 µM -0.393969335472778 0.346039350821551 no 2222 0.346801839447181 3076 5393181 SGTC_2262 9014885 67.46 µM -0.394004570040646 0.346025287813293 no 2223 0.346788832595777 3064 6457424 SGTC_2700 st077718 96.8 µM -0.396038932003993 0.345213683094295 no 2224 0.346038153883839 3141 904970 SGTC_3088 9117578 49.47 µM -0.39645547121508 0.345047593208724 no 2225 0.345884525569826 3202 678341 SGTC_729 4092-0585 94.1 µM -0.397047571890761 0.344811551723128 no 2226 0.345666190205265 3076 2169061 SGTC_690 glyoxal 20.3 µM -0.399105725632289 0.343991537131867 no 2227 0.344907651802747 3160 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_800 3448-7362 155 µM -0.399132323695586 0.343980944657943 no 2228 0.344897853081682 3185 15991913 SGTC_688 0527-0193 473 µM -0.399333156209916 0.343900968608421 no 2229 0.344823869783039 3095 4007154 SGTC_1351 1496-0003 46.5 µM -0.399989426987339 0.343639675455911 no 2230 0.344582152122766 3240 3891978 SGTC_872 0588-0139 234 µM -0.401226751627139 0.343147239877128 no 2231 0.344126593334364 3106 2047100 SGTC_1443 4112-3303 14 µM -0.402557298334765 0.342618000474909 no 2232 0.343636964315404 3124 704433 SGTC_1814 st052110 31.539 µM -0.404822295379546 0.341717783971595 no 2233 0.342804069555935 3241 674163 SGTC_1614 st002383 48.6 µM -0.408899495347896 0.34009958201244 no 2234 0.341306709694024 3204 1947235 SGTC_1627 st003713 25.6 µM -0.409643712752397 0.339804525728905 no 2235 0.341033662943698 3207 16195070 YER133W GLC7 SGTC_249 wiskostatin 11.211 µM -0.411297928665266 0.339149038381834 no 2236 0.340427044116789 3235 2775510 A n-wasp and actin depolymerizer. SGTC_560 2332-1943 155 µM -0.413183244213417 0.338402570496618 no 2237 0.339736181712308 3160 21177716 SGTC_314 1671-0008 2.74 µM -0.41389370518948 0.338121436531553 no 2238 0.339475977062579 3156 3913060 SGTC_1467 k284-1082 293 µM -0.415006994784909 0.337681082244755 no 2239 0.339068391292722 3219 3334705 SGTC_372 0155-0182 15.9 µM -0.415737273012255 0.337392346155542 no 2240 0.338801131808232 3098 771486 SGTC_704 1310-0270 142 µM -0.416100589536656 0.337248734370224 no 2241 0.338668199291573 3173 5718033 SGTC_1254 0550-0035 264 µM -0.417139894483813 0.336838048811651 no 2242 0.33828804292265 3255 15121435 SGTC_2064 5220758 200 µM -0.417485371685698 0.336701575136726 no 2243 0.338161710943024 3293 788518 SGTC_1062 mesoridazine 14.2 µM -0.417905245134842 0.336535741699109 no 2244 0.338008198729667 3166 4078 A neuroleptic. SGTC_1 0258-0098 57.368 µM -0.418347481711958 0.336361110081467 no 2245 0.337846539336036 3178 6790032 YDR047W HEM12 SGTC_2068 5226020 147 µM -0.418503109240424 0.336299663841858 no 2246 0.337789656871328 3170 1810509 SGTC_1354 1498-1681 81 µM -0.418526698121754 0.336290350652316 no 2247 0.337781035367087 3226 5754243 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.419857288613563 0.335765179457616 no 2248 0.337294855552746 3347 804 An inhibitor of viral and cellular DNA polymerases. SGTC_344 k064-0035 6.43 µM -0.420773012700516 0.335403938176602 no 2249 0.336960420021506 3124 5088750 SGTC_1818 st052136 56.3 µM -0.42123897848285 0.335220179091606 no 2250 0.336790292099213 3244 674169 SGTC_204 PMA1.184 62.41 µM -0.421705902821598 0.335036081534429 no 2251 0.336619847693181 3175 2252213 YGL008C PMA1 SGTC_490 phenamil 164 µM -0.42234411278453 0.334784514086862 no 2252 0.336386932077397 3190 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2936 9038235 15.59 µM -0.422622722614843 0.334674715842677 no 2253 0.336285272709882 3123 4749415 SGTC_3280 9140961 49.47 µM -0.422713503041249 0.334638942945197 no 2254 0.336252151263687 3117 4901226 SGTC_135 0933-0004 26.348 µM -0.423895777934227 0.334173193353086 no 2255 0.335820911709206 3265 21230617 YGL099W LSG1 SGTC_1718 roemerine 11.9335 µM -0.424474025650217 0.333945489277826 no 2256 0.335610072164796 3230 235224 An aporphine alkaloid with mutagenic activity. SGTC_528 3492-0019 172 µM -0.42594008354113 0.333368454807363 no 2257 0.335075753054935 3235 2869262 SGTC_1201 1889-3372 45.9 µM -0.426554320405366 0.333126810726182 no 2258 0.334851987529657 3134 5392199 SGTC_3086 9117350 49.47 µM -0.427515636758806 0.33274876276461 no 2259 0.334501899181628 3204 2679265 SGTC_2900 5328528 85.29 µM -0.427600498137499 0.332715398277735 no 2260 0.334471001609703 3176 795359 SGTC_1407 3909-7909 12.3 µM -0.430842300852677 0.331441830435999 no 2261 0.333291519828743 3189 4411780 SGTC_1588 farnesol 29.9 µM -0.431105377365345 0.331338563947592 no 2262 0.333195875428301 3153 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3106 9121286 49.47 µM -0.432408507975259 0.330827230016553 no 2263 0.332722267800043 3344 15943471 SGTC_483 fpl-64176 144 µM -0.432623194596185 0.330743019622028 no 2264 0.332644268030495 3247 3423 SGTC_2728 chlorpromazine 9.18 µM -0.433626481650889 0.330349595901323 no 2265 0.332279850667235 3174 2726 A thorazine and dopamine antagonist. SGTC_2737 bleomycin 30.5 nM -0.4343337910645 0.330072347927886 no 2266 0.332023034562325 3235 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2332 7982454 138.89 µM -0.434612824404564 0.329962999343548 no 2267 0.331921742382539 3250 2981748 SGTC_1294 1000-1494 117 µM -0.434667531939503 0.329941562061902 no 2268 0.331901884384008 3188 712797 YDL207W GLE1 SGTC_3219 9131112 49.47 µM -0.434998747443819 0.329811786382691 no 2269 0.331781668306752 3258 17612988 YMR079W SEC14 SGTC_2114 5491910 81.25 µM -0.43549568022833 0.329617118373843 no 2270 0.331601336925657 3270 2849228 SGTC_531 3788-1495 174 µM -0.436656345126773 0.329162620405814 no 2271 0.331180296612369 3104 2896655 SGTC_1559 coumarin 343 70.1 µM -0.436680631995984 0.329153112746551 no 2272 0.331171488636807 3313 108770 A hepatotoxic, DNA x-linker. SGTC_149 3970-0822 46.1 µM -0.436798591667062 0.32910693626431 no 2273 0.331128710227598 3298 3114250 YBL034C STU1 SGTC_1518 st038567 90.8 µM -0.438112133902376 0.32859291344932 no 2274 0.330652499445931 3250 77966 SGTC_3041 9091929 49.47 µM -0.438726308292876 0.328352682397659 no 2275 0.330429931003927 3350 25236887 SGTC_1413 3910-0535 34.4 µM -0.440071823136926 0.327826639510163 no 2276 0.329942544408347 3295 2876951 SGTC_273 hydroxyurea 18.1 mM -0.441392039072391 0.327310819337015 no 2277 0.329464602267742 3159 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1833 st055984 71 µM -0.441582365651707 0.327236484199055 no 2278 0.329395723537486 3190 676288 SGTC_1160 4092-0570 10.5 µM -0.442168682312177 0.327007531775208 no 2279 0.329183573343554 3184 4994975 SGTC_838 0109-0203 71.4 µM -0.442739041994885 0.326784872895973 no 2280 0.328977249718817 3199 759422 SGTC_2947 9072639 7.68 µM -0.443751095968127 0.326389935788554 no 2281 0.328611274538199 3270 16488146 SGTC_805 3852-0218 479 µM -0.443783719261623 0.326377208329315 no 2282 0.328599480156765 3176 6615355 SGTC_3348 9149464 3.537 µM -0.44480821390268 0.325977620955659 no 2283 0.328229178961549 3224 1951442 SGTC_1802 st050112 57.9 µM -0.446916102746519 0.325156102134295 no 2284 0.32746781846192 3226 4662563 SGTC_1757 st041620 31.8375 µM -0.447578272690794 0.324898206177034 no 2285 0.327228793338548 3244 5289815 SGTC_2665 lovastatin 100 µM -0.448587064560752 0.324505472335251 no 2286 0.326864783418756 3242 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_655 k060-0012 42 µM -0.451508065531996 0.323369395820906 no 2287 0.325811706651577 3189 5994525 SGTC_2953 9074162 66.49 µM -0.452165271426035 0.323114012426355 no 2288 0.325574962360154 3285 16451992 SGTC_3 0833-0587 95.581 µM -0.45363695465662 0.322542434039154 no 2289 0.325045075365869 3250 5382644 SGTC_2561 acetosyringone 100 µM -0.455347878789198 0.321878465195332 no 2290 0.324429493081626 3149 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_317 4495-0002 170 µM -0.455631473876893 0.321768463557735 no 2291 0.324327503209571 3234 15991618 SGTC_91 0417-1751 58.384 µM -0.455810031743801 0.32169921205732 no 2292 0.324263294844676 3301 6795624 SGTC_639 0833-0042 114 µM -0.45613296724132 0.321573981179291 no 2293 0.324147182400914 3197 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_122 0236-0016 402.397 µM -0.456360010026728 0.32148594858959 no 2294 0.324065558712618 3253 6808838 SGTC_1224 0823-0416 294 µM -0.45643348912959 0.321457460266398 no 2295 0.324039144201542 3332 3598164 SGTC_1782 st039423 80.636 µM -0.457102560956248 0.321198105127791 no 2296 0.323798664819513 3212 2068169 SGTC_1671 st016596 74.5 µM -0.458050518221286 0.320830793730332 no 2297 0.323458073693275 3281 2829167 SGTC_159 3970-0959 50 µM -0.459365362803062 0.320321612294168 no 2298 0.322985908612691 3372 6615653 SGTC_2692 st077426 47.7 µM -0.462808576473717 0.318989811045334 no 2299 0.321750791587395 3349 25238571 SGTC_465 cgp-37157 41 µM -0.463234334838763 0.318825293653942 no 2300 0.321598203966575 3251 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_946 3434-1334 87.4 µM -0.463756241395874 0.318623672314922 no 2301 0.321411198831023 3296 4047976 SGTC_1925 st057770 10.1 µM -0.46626597773526 0.317654869372542 no 2302 0.320512564161476 3204 5989122 SGTC_1030 k029-0042 36.7 µM -0.466349638442459 0.317622596295178 no 2303 0.320482626735581 3262 6080581 SGTC_407 eburnamonine 100 µM -0.466550622801989 0.317545069937503 no 2304 0.32041071059723 3216 3195 SGTC_683 panaxydol 45 µM -0.466830956240698 0.317436949362397 no 2305 0.320310413067593 3271 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2248 tofa 1.1 µM -0.46691456961531 0.317404703901409 no 2306 0.320280500465423 3142 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1959 st077091 55.8 µM -0.467156886004719 0.317311262520422 no 2307 0.32019381861312 3178 821356 YKL052C ASK1 SGTC_3350 9150499 3.57 µM -0.467418675118965 0.317210325204798 no 2308 0.320100181969193 3201 4910996 YPR165W RHO1 SGTC_1165 k072-0275 30.3 µM -0.46761196400712 0.317135808059237 no 2309 0.320031053815755 3357 6153523 YGL055W OLE1 SGTC_143 4032-1194 15.74 µM -0.468263373704986 0.316884729810973 no 2310 0.319798128608651 3210 1806963 SGTC_1965 Pectolinarigenin 58.4 µM -0.47070136770152 0.315945782523911 no 2311 0.318927003788672 3235 5320438 An anti-inflammatory. SGTC_773 4358-1457 44.6 µM -0.471523627992807 0.315629371707192 no 2312 0.318633425321587 3350 1186886 SGTC_1183 1254-0324 198 µM -0.472181673130365 0.315376249199188 no 2313 0.318398559937125 3342 5799357 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.472714446841565 0.315171376832375 no 2314 0.318208459100571 3277 16486 A toxic proline analog. SGTC_1149 3909-7961 23.3 µM -0.474815978947687 0.31436381011276 no 2315 0.317459071367181 3273 735261 SGTC_3355 9151058 44.0485 µM -0.476645080812882 0.31366165382276 no 2316 0.316807438098893 3338 17015728 SGTC_2525 harmine 47.85 µM -0.478169249772362 0.313077070316687 no 2317 0.316264873482312 3240 5280953 A monoamine oxidase inhibitor SGTC_2855 9016525 58.44 µM -0.478234637336275 0.313052001903879 no 2318 0.316241606041264 3269 43811474 SGTC_1848 st056003 16.4 µM -0.47915284572678 0.312700068681502 no 2319 0.315914948626518 3356 146492 SGTC_706 4262-0057 46.9 µM -0.479957187702677 0.31239191869382 no 2320 0.315628917836934 3247 883298 SGTC_2783 7738165 71.43 µM -0.484791322943438 0.310542690812904 no 2321 0.313912189212194 3273 17201110 SGTC_1037 k284-1091 78.7 µM -0.486311061080824 0.309962321985908 no 2322 0.31337331900756 3329 3334711 SGTC_674 0498-0004 451 µM -0.486541190539225 0.309874479667802 no 2323 0.313291754167266 3311 4231473 SGTC_579 4491-1009 110 µM -0.486919217977926 0.309730207026885 no 2324 0.313157789632563 3413 1271041 SGTC_2387 9077560 195.08 µM -0.48695835183152 0.309715273423727 no 2325 0.313143922871448 3238 5303272 SGTC_1970 st070122 35.8 µM -0.488194962075087 0.309243540890208 no 2326 0.312705876331304 3404 102928 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.488384823054798 0.309171142000296 no 2327 0.312638644953196 3216 279621 SGTC_1597 7-benzyloxygramine 47.5 µM -0.488771361585424 0.30902376778795 no 2328 0.312501787658264 3328 260807 SGTC_1136 pergolide 1.05886 µM -0.488793749993992 0.30901523277802 no 2329 0.312493861641391 3210 47811 A dopamine receptor agonist. SGTC_3229 9132204 49.47 µM -0.490205605130938 0.308477207425276 no 2330 0.311994207443451 3256 17682924 SGTC_2655 perillic acid 100 µM -0.491428975852515 0.308011341423901 no 2331 0.311561537220661 3261 5702197 An apoptosis inducer. SGTC_1761 st044296 37 µM -0.492094013003506 0.307758221459407 no 2332 0.311326442223812 3250 1826700 SGTC_1406 3909-7906 11.9 µM -0.494669160493362 0.306778957549963 no 2333 0.310416837030607 3327 X1406 SGTC_1285 0929-0069 65.5 µM -0.496704976258365 0.306005762311794 no 2334 0.309698556368813 3295 1206237 SGTC_914 3820-6779 408 µM -0.497615247301449 0.305660323940102 no 2335 0.309377627419432 3248 2893481 SGTC_2674 ligustilide 100 µM -0.498444332095777 0.305345845327164 no 2336 0.309085448297776 3334 5319022 A signalling regulator. SGTC_3142 9086498 49.47 µM -0.498629961975411 0.305275454070418 no 2337 0.309020046704576 3315 25236367 SGTC_2269 7935389 174.42 µM -0.498633440898092 0.305274134924053 no 2338 0.309018821059434 3332 97605 SGTC_2521 angolensin 13.4 µM -0.50026000134617 0.304657649033305 no 2339 0.308446007217828 3384 821428 A flavenoid. SGTC_2021 4019055 173 µM -0.502520483926773 0.303801819758511 no 2340 0.307650723586162 3431 44827708 YER133W GLC7 SGTC_1865 st057639 52.2 µM -0.503974077060401 0.303252049877133 no 2341 0.30713979681153 3324 688818 SGTC_1266 0828-0227 32.9 µM -0.504498544241891 0.303053798074172 no 2342 0.306955542453315 3314 3913820 SGTC_3347 9188721 44.724 µM -0.505757166639549 0.302578267832681 no 2343 0.306513565645769 3348 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2863 9028737 58.44 µM -0.505815868712376 0.30255609729537 no 2344 0.306492958734781 3305 6460917 SGTC_814 3342-0569 96 µM -0.50587040156153 0.302535502038505 no 2345 0.306473815945901 3419 4346283 SGTC_2205 7238770 200 µM -0.507089063391491 0.302075417741031 no 2346 0.306046164178803 3388 279867 SGTC_565 1418-0001 44.5 µM -0.507938626435041 0.301754866157691 no 2347 0.305748192500132 3431 2862145 SGTC_3185 9108267 49.47 µM -0.508997350306279 0.301355609551591 no 2348 0.30537704069716 3369 4910486 SGTC_3051 9093778 49.47 µM -0.510400448407111 0.300826852363121 no 2349 0.304885471399457 3333 17217378 SGTC_43 0570-0105 72.5 µM -0.511576735130286 0.300383891761761 no 2350 0.304473635624793 3347 1114046 YDL195W SEC31 SGTC_993 3909-8757 62.7 µM -0.511837402060925 0.300285770921312 no 2351 0.304382405709009 3280 4288324 YLR208W SEC13 SGTC_3324 9138759 60.749 µM -0.51251222258271 0.30003182076602 no 2352 0.304146284163574 3403 45595710 SGTC_2820 7989630 71.43 µM -0.512597391815657 0.299999776572656 no 2353 0.304116489017276 3323 2984098 SGTC_297 0986-0032 24 µM -0.512706515706177 0.299958721908101 no 2354 0.304078315603432 3302 2847425 SGTC_2486 5283202 22.39 µM -0.516216649133541 0.298639495737288 no 2355 0.302851551638444 3315 1377751 SGTC_997 3996-0078 137 µM -0.519324750486144 0.297473573913597 no 2356 0.301767148247558 3331 735687 SGTC_1895 st058434 18.3 µM -0.519425828549811 0.297435692078337 no 2357 0.301731911861389 3441 5393175 SGTC_1888 azatryptophan 97.5 µM -0.520811164854659 0.296916720675644 no 2358 0.301249162310163 3368 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_165 k038-0023 64.381 µM -0.522265983924344 0.296372166255259 no 2359 0.300742574851458 3323 46368543 SGTC_1056 3448-1962 115 µM -0.523284796035157 0.295991086738076 no 2360 0.300388039872786 3382 715507 SGTC_1664 st014217 9.02 µM -0.524010894614727 0.295719632024896 no 2361 0.300135481169986 3454 3982782 SGTC_3006 9075424 71.4286 µM -0.524735933243423 0.295448687783003 no 2362 0.299883387015487 3320 7465181 SGTC_2747 doxorubicin 7.63 µM -0.525001666468852 0.295349412865482 no 2363 0.299791016232266 3306 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.525100904221819 0.295312342703802 no 2364 0.299756523778919 3286 688803 SGTC_973 1325-0077 65.9 µM -0.526207429635122 0.294899146380096 no 2365 0.299372046226974 3353 2835149 SGTC_2167 5876490 200 µM -0.526729589593779 0.294704255114991 no 2366 0.299190692233204 3451 686534 SGTC_1712 st032288 53.4 µM -0.527745025148012 0.294325423575293 no 2367 0.29883815904684 3430 2883011 SGTC_1077 5-fluorocytosine 377 nM -0.52884991541444 0.293913474563918 no 2368 0.298454784046165 3391 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2054 5233173 129 µM -0.529383280819141 0.293714709249877 no 2369 0.298269796959169 3415 6889 SGTC_885 0865-0106 16.8 µM -0.531439374927708 0.292949062730858 no 2370 0.297557171022307 3366 2793380 SGTC_2886 9058944 51.95 µM -0.531451658407825 0.292944491403638 no 2371 0.297552916001815 3266 4949929 SGTC_600 1495-0418 41.6 µM -0.532076912046008 0.292711845469986 no 2372 0.297336363674229 3357 5377768 SGTC_335 4077-0256 27.6 µM -0.534095236836284 0.291961448328192 no 2373 0.296637822517537 3406 3121989 SGTC_2065 5221596 34.26 µM -0.537306008137253 0.29076955855639 no 2374 0.295528127996685 3419 788581 SGTC_277 nystatin 15.5 µM -0.53787656466422 0.290557997127137 no 2375 0.295331134343843 3291 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1680 diphenhydramine 100 µM -0.53959274911433 0.289922073291552 no 2376 0.294738959090512 3350 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1917 st066507 28.5 µM -0.539838946697712 0.289830899528591 no 2377 0.294654052708214 3294 3156428 SGTC_303 1348-1668 34.2 µM -0.5402951632784 0.289661985495576 no 2378 0.294496746716062 3397 5380509 SGTC_2302 7771753 200 µM -0.541054133766964 0.289381079354082 no 2379 0.294235135418075 3392 2203047 SGTC_815 1582-0027 36.9 µM -0.54121341388501 0.28932214369198 no 2380 0.294180246416857 3427 3128206 SGTC_1399 3562-5772 25 µM -0.541534573574868 0.289203327692212 no 2381 0.294069587014268 3389 23847490 SGTC_1734 st037168 69.4 µM -0.542708291229469 0.288769295204587 no 2382 0.293665332334279 3382 708907 SGTC_349 k015-0014 24 µM -0.543725232672012 0.28839348560383 no 2383 0.29331528302544 3311 2196908 SGTC_642 0335-0876 158 µM -0.54539364745503 0.287777424660939 no 2384 0.292741404287415 3408 6812350 SGTC_574 1315-0397 40 µM -0.545602131886516 0.287700485655231 no 2385 0.29266972929822 3426 6794277 SGTC_1844 rapamycin 4 nM -0.545773461123259 0.287637265663685 no 2386 0.292610834018507 3400 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_200 k038-0079 37.545 µM -0.546559974217539 0.287347128901422 no 2387 0.292340536903987 3350 3436683 SGTC_810 3825-7150 143 µM -0.547065527187377 0.287160708631529 no 2388 0.292166857310123 3481 22330411 YGL099W LSG1 SGTC_1323 1348-1351 11.2 µM -0.55404927053492 0.284591363218315 no 2389 0.289772563337701 3365 6989654 SGTC_1389 3405-0187 19 µM -0.5547259576864 0.284342991998432 no 2390 0.289541059211699 3371 799890 SGTC_1369 1866-0067 208 µM -0.554799168709296 0.284316126839419 no 2391 0.289516017905446 3482 3531355 SGTC_2056 5235370 200 µM -0.556423592629868 0.283720348493369 no 2392 0.28896065715182 3358 5511916 SGTC_868 0527-0199 213 µM -0.55712950431605 0.283461632803819 no 2393 0.288719475225603 3340 2849450 SGTC_378 3970-0959 8.33 µM -0.557215426839759 0.283430150034796 no 2394 0.28869012539157 3449 6615653 SGTC_1867 st057372 64 µM -0.557338412944069 0.28338508976046 no 2395 0.288648117644323 3452 688837 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.557458627867104 0.283341048125241 no 2396 0.288607059218303 3513 5393153 SGTC_517 1365-0151 113 µM -0.558576324063075 0.282931728964535 no 2397 0.288225450968946 3498 768657 SGTC_1043 0916-0009 19.3 µM -0.559907756061782 0.282444507020591 no 2398 0.287771179068195 3502 3101130 SGTC_899 1083-0020 478 µM -0.560264261216415 0.282314116655683 no 2399 0.287649600343435 3501 767123 SGTC_1667 st014849 34.6 µM -0.560338033226624 0.282287138448785 no 2400 0.287624444953803 3474 5348460 SGTC_1904 st060225 78 µM -0.563261259167866 0.281219123043869 no 2401 0.286628497138705 3462 66595 SGTC_2358 9037157 4 µM -0.563905464296596 0.280984022078994 no 2402 0.286409235535865 3443 2388925 SGTC_1581 himbacine 57.9 µM -0.564761955072601 0.280671595188192 no 2403 0.286117843743741 3390 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2862 9027634 71.43 µM -0.564937876273961 0.280607444244851 no 2404 0.286058009991078 3392 5012562 SGTC_2738 aclarubicin 5.55 µM -0.565142594601277 0.280532801152927 no 2405 0.285988389338693 3366 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2282 7944268 200 µM -0.565627336163241 0.280356096098017 no 2406 0.285823570443272 3527 2970414 SGTC_937 3122-0005 46.7 µM -0.566301385897226 0.280110471288911 no 2407 0.285594459232453 3482 759535 SGTC_1990 st072050 59.8 µM -0.566885578507449 0.27989767495789 no 2408 0.285395961413866 3390 17233948 SGTC_1612 st002233 45.4 µM -0.567800884079614 0.279564426092573 no 2409 0.285085089728358 3488 1035021 SGTC_3123 9126162 49.47 µM -0.568092135951441 0.279458426120635 no 2410 0.284986203668479 3451 25239884 SGTC_1087 pterostilbene 9.05 µM -0.568121273345566 0.279447822754906 no 2411 0.284976311818105 3506 5281727 Similar to reservatol, lowers cholesterol. SGTC_889 0919-1524 82.7 µM -0.568408825071247 0.279343190517624 no 2412 0.284878699700564 3424 3905452 SGTC_2938 9059746 27.26 µM -0.569506323014838 0.278944015969662 no 2413 0.284506290465619 3439 6471769 SGTC_577 r071-0003 38.6 µM -0.569513596180468 0.278941371548747 no 2414 0.284503823269568 3455 4568517 YMR134W ERG29 SGTC_1297 1068-0111 14.1 µM -0.569525306666717 0.278937113805976 no 2415 0.284499850871478 3401 767057 SGTC_3009 9080819 71.4286 µM -0.571091865335634 0.278367823684159 no 2416 0.283968686237638 3443 17027216 SGTC_2789 5281112 71.43 µM -0.571528469221068 0.278209262042102 no 2417 0.283820733904099 3407 765948 SGTC_1053 3366-3204 134 µM -0.572072675660965 0.278011684009769 no 2418 0.283636369884401 3426 3632071 YPR165W RHO1 SGTC_3356 9151811 4.48 µM -0.572203043372332 0.277964363248704 no 2419 0.283592212966404 3395 1859254 YPR165W RHO1 SGTC_980 1473-0395 201 µM -0.572496080610497 0.277858011190757 no 2420 0.28349297018877 3435 768876 SGTC_377 3970-0964 33.1 µM -0.572879062271467 0.277719045540167 no 2421 0.283363291075329 3475 16481235 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.573773103649577 0.277394773033684 no 2422 0.283060675853341 3389 6708630 An antioxidant. SGTC_116 0155-0182 31.788 µM -0.575354515739098 0.276821642027668 no 2423 0.282525779462739 3427 771486 SGTC_1982 st072467 71.9 µM -0.575505660272508 0.276766895023943 no 2424 0.282474681832202 3352 3163533 SGTC_2089 5281248 129.67 µM -0.575791622759371 0.276663329282109 no 2425 0.282378018279277 3498 2737878 SGTC_1963 st076565 50.3 µM -0.576384202783157 0.276448777724486 no 2426 0.282177759837643 3469 4914280 SGTC_370 0180-0345 38.7 µM -0.577572479719061 0.27601879210428 no 2427 0.281776395732503 3411 3989527 SGTC_2342 7990637 118.86 µM -0.579328823972505 0.275383849749263 no 2428 0.281183660031181 3488 2033102 YER133W GLC7 SGTC_684 1140-0066 328 µM -0.579371072820422 0.275368585072057 no 2429 0.281169409198046 3486 6813534 SGTC_707 0865-0008 204 µM -0.580701413958807 0.274888140594556 no 2430 0.280720854299231 3469 723043 SGTC_2401 5128683 200 µM -0.580955422458084 0.274796453986188 no 2431 0.28063524889904 3410 708373 SGTC_934 2950-0684 338 µM -0.5819728735949 0.274429347228958 no 2432 0.28029247636747 3513 1121253 SGTC_2109 5483026 200 µM -0.582593603418031 0.274205500513103 no 2433 0.280083456252523 3464 759335 SGTC_2011 4012611 177 µM -0.583595489633634 0.273844392061061 no 2434 0.27974624771927 3454 2049887 SGTC_2946 9065502 71.43 µM -0.584082388473956 0.273668984734663 no 2435 0.279582441541123 3366 16489101 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.585192400923657 0.273269306069112 no 2436 0.279209176959777 3486 688669 SGTC_3184 9108758 49.47 µM -0.58734156712657 0.272496285398552 no 2437 0.278487164724212 3491 902885 SGTC_3054 9094397 49.47 µM -0.587461262335642 0.272453264889872 no 2438 0.278446979882902 3438 2598354 SGTC_1719 st032227 49.2 µM -0.587494241312519 0.27244141227333 no 2439 0.278435908466297 3478 3125804 SGTC_1147 3809-1045 12.3 µM -0.588227630873752 0.272177898867981 no 2440 0.278189756711738 3441 325925 SGTC_2842 9000675 19.48 µM -0.588441242444278 0.272101170157236 no 2441 0.278118080993275 3436 2989072 SGTC_1442 4112-3290 3 µM -0.591435665114356 0.271026714768458 no 2442 0.277114274786002 3494 704353 SGTC_115 0527-0192 112.043 µM -0.591859358461335 0.270874856686 no 2443 0.276972385365107 3513 4233931 SGTC_3056 9094900 49.47 µM -0.591863664165715 0.270873313674629 no 2444 0.27697094362299 3430 25236784 SGTC_2352 9027995 87.8 µM -0.592117276953208 0.270782435607503 no 2445 0.27688602921778 3443 2997347 SGTC_72 0744-0168 198.391 µM -0.592305771297323 0.270714901549764 no 2446 0.276822925970988 3389 677577 SGTC_3111 9122088 49.47 µM -0.59262764587845 0.270599599250802 no 2447 0.276715186604884 3423 16876704 SGTC_1794 st048918 76.9 µM -0.593134862630505 0.270417953253813 no 2448 0.276545450348364 3462 672303 SGTC_2273 7815444 169.05 µM -0.593214553714674 0.270389419582072 no 2449 0.27651878696908 3510 2824616 SGTC_3181 9108277 49.47 µM -0.593856043661595 0.27015978668597 no 2450 0.276304200474972 3433 17097298 SGTC_1515 3460-0031 42.1 µM -0.594274068235899 0.270010199760203 no 2451 0.276164409951982 3473 2876596 SGTC_2802 7925815 54.55 µM -0.594512591074228 0.269924864745541 no 2452 0.276084661700692 3453 1262923 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.596016911869815 0.269386983332264 no 2453 0.275581964440526 3471 6708561 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.596163005141012 0.269334775207372 no 2454 0.275533168598324 3482 4330530 SGTC_427 1354-0053 47.3 µM -0.596600649163915 0.269178408410554 no 2455 0.27538701886504 3582 6813657 SGTC_3112 9123419 49.47 µM -0.597132435741366 0.268988466525258 no 2456 0.275209481896072 3541 17015854 SGTC_2717 st081029 62.2815 µM -0.598545650151814 0.268484026159742 no 2457 0.274737954235619 3513 5292846 SGTC_92 0063-0024 660.874 µM -0.599542621127105 0.268128448297191 no 2458 0.274405548552683 3544 3594437 SGTC_341 1486-1430 230 µM -0.599643816997257 0.268092369215712 no 2459 0.274371819370608 3462 2054753 YPL210C SRP72 SGTC_466 geldanamycin 89.2 µM -0.60021402206984 0.267889121278516 no 2460 0.27418180491024 3422 5288382 HSP90 inhibitor. SGTC_2347 9049783 174.81 µM -0.600408418436725 0.267819847003532 no 2461 0.274117039356224 3524 6467988 YPL169C MEX67 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.60087018968193 0.267655328324131 no 2462 0.273963224860589 3492 6708739 YPR165W RHO1 SGTC_2797 7859098 81.82 µM -0.605278523977916 0.266087306935439 no 2463 0.272496974276882 3498 972681 SGTC_3082 9117008 49.47 µM -0.607288262408216 0.265374000560701 no 2464 0.271829813246033 3473 41448529 SGTC_1164 k060-0068 93.7 µM -0.608661349460604 0.264887216296743 no 2465 0.271374465437288 3563 5963676 SGTC_2768 sulfasalazine 50.2 µM -0.60893193165295 0.264791343558893 no 2466 0.271284778897864 3585 5384001 An antioxidant and salicylic acid derivative. SGTC_310 1273-0058 1.06 µM -0.60996130607646 0.26442677669218 no 2467 0.270943719929764 3554 2734232 SGTC_589 1227-0070 34.1 µM -0.611983389277047 0.263711373171434 no 2468 0.270274373805703 3553 2841384 SGTC_582 0987-0078 156 µM -0.612330770766858 0.263588570676956 no 2469 0.270159467520063 3594 1625765 SGTC_892 0929-0076 29 µM -0.612396318111714 0.263565402371169 no 2470 0.270137788616207 3518 5751038 SGTC_1152 3909-8331 15.9 µM -0.612502704489657 0.263527801349411 no 2471 0.270102604603097 3506 16001939 SGTC_1091 telmisartan 47.6 µM -0.612935469697563 0.263374873768331 no 2472 0.269959504492706 3599 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2181 6316240 54.2555 µM -0.613910980887997 0.263030320619227 no 2473 0.269637076753425 3521 12779990 SGTC_2908 7930301 100 µM -0.616049413056989 0.262275827543807 no 2474 0.268930953900368 3459 2223178 SGTC_467 ro 31-8220 72.8 µM -0.617100411423626 0.261905415420946 no 2475 0.268584248668228 3480 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2105 5350118 200 µM -0.618322139837665 0.261475168903446 no 2476 0.268181505247425 3545 2133313 SGTC_1812 st052057 4.327 µM -0.618672011476464 0.261352024229132 no 2477 0.268066225877246 3541 3645418 SGTC_2594 a-mangostin 100 µM -0.618678028915113 0.261349906525777 no 2478 0.268064243406791 3558 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2795 7780010 54.55 µM -0.620008273618473 0.260881972999362 no 2479 0.267626169933469 3525 953673 SGTC_1161 k007-0610 110 µM -0.620771403767347 0.26061372517305 no 2480 0.267375020461479 3605 5843850 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.62184373816435 0.260237029053752 no 2481 0.267022311544491 3539 17037758 SGTC_2187 6125751 200 µM -0.621933369013535 0.260205555697706 no 2482 0.266992841086436 3527 874498 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.622059844140985 0.260161148023032 no 2483 0.266951259092105 3539 23665772 A membrane-active detergent. SGTC_203 k066-0004 30.888 µM -0.622692264180848 0.25993915267739 no 2484 0.266743383606489 3607 6795412 SGTC_2195 6536160 144.242 µM -0.624393929024204 0.25934231100127 no 2485 0.26618445554869 3436 3834386 SGTC_2867 9039098 71.43 µM -0.625116644875282 0.259089040137691 no 2486 0.265947252148807 3533 6463460 SGTC_1784 st039334 36.3 µM -0.626308296160152 0.258671713493122 no 2487 0.265556372917285 3640 3496984 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.626769170194537 0.258510404767782 no 2488 0.26540527760714 3517 803109 SGTC_1778 st046819 58.9 µM -0.626797254880855 0.258500576640572 no 2489 0.265396071589828 3549 671715 SGTC_1705 st027868 56.3335 µM -0.62687085024474 0.258474823146079 no 2490 0.265371948172671 3570 292948 SGTC_3325 9138760 55.175 µM -0.628312982981314 0.257970440679023 no 2491 0.264899464131384 3519 43844959 SGTC_2052 5265182 7.135 µM -0.628401356438981 0.257939548884849 no 2492 0.264870524361429 3548 1239884 SGTC_592 k241-0073 46.5 µM -0.628411973928049 0.257935837568319 no 2493 0.264867047546751 3578 4230158 SGTC_295 k015-0027 31 µM -0.629041133559707 0.257715965875227 no 2494 0.264661063663713 3538 3887424 SGTC_2235 salicylic acid 500 µM -0.629047274484583 0.257713820292841 no 2495 0.264659053555569 3559 338 A COX inhibitor and kinase inhibitor. SGTC_727 3032-0951 202 µM -0.630200134296708 0.257311186073027 no 2496 0.264281825715069 3521 3652836 SGTC_2504 purpurogallin 52.29 µM -0.630583436661136 0.257177390867236 no 2497 0.264156465827337 3503 5281571 An antioxidant. SGTC_905 2-aminofluorene 215 µM -0.631385302349636 0.256897609326646 no 2498 0.263894311874736 3611 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3271 9137798 49.47 µM -0.632020694538636 0.256676025116797 no 2499 0.263686677328262 3514 6498326 SGTC_1846 st056244 14.8 µM -0.632641173876822 0.256459737636248 no 2500 0.263483996481703 3520 5393182 SGTC_2595 hexamethylquercetagetin 100 µM -0.632868631238068 0.256380474050297 no 2501 0.26340971699101 3505 386331 SGTC_2779 methotrexate 400 µM -0.634043281625037 0.255971339079738 no 2502 0.263026288151846 3629 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1684 st024538 14.6195 µM -0.634146496670059 0.255935405195077 no 2503 0.262992610383394 3522 6732859 SGTC_2283 7944793 200 µM -0.634160364228359 0.255930577463458 no 2504 0.26298808574185 3539 2970533 SGTC_664 1222-0054 14.9 µM -0.634865453628628 0.255685176391335 no 2505 0.262758084952175 3579 6813991 SGTC_3157 9099274 49.47 µM -0.635071723124288 0.255613409079075 no 2506 0.262690819117085 3568 17217662 SGTC_121 0557-0495 61.343 µM -0.635281655043427 0.255540378304576 no 2507 0.262622367988721 3664 3104427 SGTC_3346 9158254 43.5805 µM -0.635782397395248 0.255366224886659 no 2508 0.262459131062038 3542 17639500 SGTC_2612 dictamnine 15.46 µM -0.636996166752505 0.254944345026511 no 2509 0.262063670233709 3510 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2626 ethyl orsellinate 100 µM -0.638566175792195 0.254399185459801 no 2510 0.261552595591323 3566 75653 A natural product. SGTC_1723 st034307 2.5525 µM -0.640730467564894 0.253648673904483 no 2511 0.260848907768087 3579 867466 SGTC_632 0781-2353 4.65 µM -0.641975886922436 0.253217327486483 no 2512 0.2604444197699 3598 6811515 YHR007C ERG11 SGTC_368 fentichlor 4.58 µM -0.643455697911158 0.252705302287519 no 2513 0.259964226212785 3530 7329 A pesticide. SGTC_3119 9125183 49.47 µM -0.643749800460249 0.252603605687756 no 2514 0.259868845371969 3437 22695334 SGTC_2638 epoxomicin 18 µM -0.645680305227147 0.251936599365866 no 2515 0.259243208947164 3566 9915668 A protesome inhibitor. SGTC_1075 aripiprazole 15.2 µM -0.645879118750828 0.251867960381575 no 2516 0.259178821862384 3604 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1872 amphotericin b 148 nM -0.646948983960073 0.251498766420427 no 2517 0.258832480867879 3570 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.647803116198379 0.251204223986248 no 2518 0.258556149818389 3601 442882 SGTC_2038 4100038 30.985 µM -0.64914476660264 0.250741932393846 no 2519 0.2581224043095 3594 3596803 SGTC_318 1488-0629 67.2 µM -0.649547755563828 0.250603162786933 no 2520 0.257992194723863 3590 3662576 SGTC_3137 9097352 49.47 µM -0.650005585627088 0.25044555797695 no 2521 0.257844306805979 3697 44120435 SGTC_1377 2944-0135 198 µM -0.650696813157728 0.250207707275431 no 2522 0.257621110392678 3640 1894137 SGTC_1328 1441-0025 69.2 µM -0.650854650096506 0.250153412547846 no 2523 0.25757015913689 3551 4562601 SGTC_702 1488-0190 94 µM -0.652409995667741 0.249618719662435 no 2524 0.257068358903561 3588 949357 SGTC_1873 rapamycin 2 nM -0.652675387970973 0.249527544418531 no 2525 0.256982786349327 3596 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_503 tyrphostin 8 294 µM -0.653023877526785 0.249407848079601 no 2526 0.256870442595302 3582 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_140 0062-0056 502.533 µM -0.65327122360368 0.249322910195362 no 2527 0.256790720316427 3584 3758964 SGTC_1049 3226-0134 66 µM -0.654414747878962 0.248930427442456 no 2528 0.256422317719791 3630 5702385 SGTC_728 3030-5151 22.5 µM -0.656842127335026 0.24809838831111 no 2529 0.255641216656409 3631 3125388 SGTC_2073 5212005 126 µM -0.657517378708077 0.247867194678421 no 2530 0.255424150132538 3498 691789 SGTC_2620 irigenin 100 µM -0.658622555190504 0.247489050878821 no 2531 0.255069087674887 3628 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1995 st072814 61.1 µM -0.660346822290092 0.24689969710979 no 2532 0.254515644689822 3569 5769371 SGTC_2237 6667747 47.222 µM -0.660636189754557 0.246800865089118 no 2533 0.254422827270179 3538 729940 YDL015C TSC13 SGTC_1578 josamycin 24.2 µM -0.661048836129767 0.246659964412569 no 2534 0.254290497635624 3547 5282165 A P450 substrate. SGTC_701 4424-0219 185 µM -0.661765664468381 0.246415301366105 no 2535 0.254060707123929 3645 2911779 SGTC_1721 st082152 9.2685 µM -0.662232667465339 0.246255977024551 no 2536 0.253911060647451 3589 5296051 SGTC_1242 0402-0103 60.1 µM -0.662538331110696 0.246151725681681 no 2537 0.253813138819246 3584 432868 SGTC_2524 avocatin b 10.57 µM -0.662959850926132 0.246007998624747 no 2538 0.253678134054549 3559 6710748 SGTC_2928 9011484 9.79 µM -0.664183497164494 0.245591022963893 no 2539 0.25328643722407 3604 2994751 SGTC_2257 7960413 200 µM -0.665800204440715 0.245040688543685 no 2540 0.252769407100196 3603 2974689 YIL048W NEO1 SGTC_1051 3253-3903 78 µM -0.666120903624787 0.244931600003052 no 2541 0.252666912173969 3605 5509239 SGTC_3261 9137475 49.47 µM -0.667092012864341 0.244601428414464 no 2542 0.252356680819474 3504 17027690 SGTC_2699 st077704 54.6 µM -0.668461909472484 0.244136079271653 no 2543 0.251919394166723 3624 645852 SGTC_320 4092-0846 5.34 µM -0.669857069520464 0.243662639360086 no 2544 0.251474454528632 3604 1359356 SGTC_992 3909-8734 162 µM -0.67046217071146 0.243457455823808 no 2545 0.251281606935885 3629 4288319 SGTC_9 0092-0002 10.449 µM -0.670886725738596 0.243313549359847 no 2546 0.251146346648019 3608 759368 SGTC_2295 7971645 200 µM -0.671120335305701 0.243234385062595 no 2547 0.251071936688176 3621 2978226 YKL099C UTP11 SGTC_538 2922-0838 53.3 µM -0.673786030113354 0.242332036090137 no 2548 0.250223678818156 3666 777039 SGTC_2178 5812956 200 µM -0.673791902660298 0.242330050212666 no 2549 0.250221811778486 3623 5403383 SGTC_1109 tnp00067 928.257 nM -0.674285758412815 0.242163078080465 no 2550 0.250064828269063 3617 676295 SGTC_402 epigallocatechin gallate 10 µM -0.676443821046426 0.241434171613412 no 2551 0.249379451488978 3615 65064 An antioxidant. SGTC_3335 9143315 29.6265 µM -0.676629148445812 0.241371631112045 no 2552 0.249320640151781 3622 4899691 SGTC_1697 st025554 27.742 µM -0.676736953545179 0.241335255300789 no 2553 0.249286432941386 3616 1269519 SGTC_1806 st050005 60.3 µM -0.677351671156105 0.241127892987452 no 2554 0.24909142701478 3619 5194765 SGTC_2939 9044578 71.43 µM -0.677511219931902 0.241074088334117 no 2555 0.249040826868643 3632 2653634 SGTC_1694 st024011 44.9 µM -0.678129552441432 0.240865629670976 no 2556 0.248844777291021 3689 2787533 SGTC_2010 4012422 159 µM -0.678500190488212 0.240740723354717 no 2557 0.248727301544169 3613 952393 SGTC_271 rotenone 740 µM -0.679193485260253 0.240507175261706 no 2558 0.248507637302444 3679 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_3029 9088683 49.47 µM -0.682358472407376 0.239442564633255 no 2559 0.247506153932517 3656 25236615 SGTC_2995 9067767 71.4286 µM -0.684840284708035 0.238609557850795 no 2560 0.246722355713457 3630 11673567 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.68642788114191 0.23807752267999 no 2561 0.246221663865465 3619 6857784 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.687825226483955 0.23760978291715 no 2562 0.245781424097939 3671 2724 A muscle relaxant with antifungal properties. SGTC_928 2764-0428 58.7 µM -0.688776052910024 0.237291796988736 no 2563 0.245482103842 3675 662578 SGTC_1771 st048882 4.1505 µM -0.691680706845453 0.236321839448112 no 2564 0.244568932794681 3651 4580403 SGTC_192 3455-0609 60.9 µM -0.692395725900778 0.236083406813397 no 2565 0.24434442460136 3714 3769639 SGTC_302 1094-0063 18.9 µM -0.69296069813804 0.235895103063642 no 2566 0.244167108060902 3615 5440289 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.694299009079427 0.235449378080267 no 2567 0.24374735615038 3736 688801 SGTC_1837 st055472 66.5 µM -0.694366660126105 0.235426859220059 no 2568 0.243726148218636 3724 676091 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.695419166277293 0.235076666872705 no 2569 0.243396326331627 3683 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2832 7992762 51.95 µM -0.695613677872863 0.235011980029013 no 2570 0.243335399010438 3597 2985177 SGTC_1836 st055642 81 µM -0.696279908492731 0.234790492687654 no 2571 0.243126776515491 3664 8571 SGTC_792 4534-1957 155 µM -0.697299830047028 0.234451644995141 no 2572 0.242807587204129 3666 1717904 SGTC_2884 9058502 51.95 µM -0.698990426167209 0.233890576068918 no 2573 0.242279006987572 3659 6471554 SGTC_2307 7538926 6.34 µM -0.699006856516989 0.233885126876671 no 2574 0.242273872951352 3686 96582 SGTC_2874 9043904 71.43 µM -0.699365570987596 0.233766175300068 no 2575 0.242161799159649 3650 4463428 SGTC_2144 5628481 200 µM -0.699731538154308 0.233644853255275 no 2576 0.242047488366478 3666 2818399 SGTC_3113 9123498 49.47 µM -0.699934132049307 0.233577706219021 no 2577 0.241984220223912 3705 8897275 SGTC_533 1222-0222 6.71 µM -0.700450081088307 0.233406750150545 no 2578 0.241823134774308 3760 3982874 SGTC_2151 5563267 85.4165 µM -0.70076938061573 0.233300987289952 no 2579 0.241723474804807 3703 5310824 SGTC_331 k048-0133 24.5 µM -0.700853714922964 0.233273057340182 no 2580 0.241697156049827 3648 6813582 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.701011767134146 0.233220718393417 no 2581 0.241647835859293 3692 165521 SGTC_1130 3454-2858 15.9 µM -0.701219014638056 0.233152098316883 no 2582 0.241583172558445 3687 715628 YIL048W NEO1 SGTC_869 0564-0080 44.1 µM -0.70125829825895 0.233139092692615 no 2583 0.241570916733852 3687 6843321 SGTC_208 k072-0098 12.366 µM -0.701895441244156 0.232928210080685 no 2584 0.241372186061441 3674 5948901 SGTC_46 0329-0187a 2.197 µM -0.702379719526541 0.232767993773868 no 2585 0.241221194707571 3691 46494817 SGTC_1503 4585-0012 61.3 µM -0.703363249160013 0.232442796100861 no 2586 0.240914701665876 3684 2922052 SGTC_1374 2889-5571 141 µM -0.70470811712893 0.231998533527331 no 2587 0.240495949426847 3695 2853281 SGTC_2488 5268135 45.7 µM -0.705129529062683 0.231859422001988 no 2588 0.24036481577978 3708 1270356 YLR208W SEC13 SGTC_543 3844-1095 191 µM -0.705929370801774 0.231595515526671 no 2589 0.240116030689384 3694 4230703 SGTC_3213 9129884 49.47 µM -0.705963335498222 0.231584312637511 no 2590 0.240105469319587 3641 17190742 SGTC_3148 9097893 49.47 µM -0.707582332389528 0.231050654446452 no 2591 0.23960233381518 3648 17174100 SGTC_1324 1418-0026 34.4 µM -0.709070893740214 0.230560597036902 no 2592 0.239140242038831 3737 1372513 SGTC_415 dibenzyl ketone 100 µM -0.709147385673189 0.230535430411091 no 2593 0.239116509931651 3699 7593 SGTC_1764 st044502 93.5 µM -0.709584286374961 0.230391715057297 no 2594 0.238980983395433 3705 8407 SGTC_429 1112-0049 25.5 µM -0.710707462221041 0.230022484416437 no 2595 0.238632767252334 3674 2836170 SGTC_1300 1094-0077 113 µM -0.711158611415516 0.229874267779599 no 2596 0.238492976501989 3654 5532636 SGTC_2873 9040596 71.43 µM -0.711681441687002 0.229702568567289 no 2597 0.23833103112217 3671 6463863 SGTC_1838 st055369 84.5 µM -0.711717474314349 0.229690737978039 no 2598 0.238319872324107 3670 676036 SGTC_1119 parthenolide 318.541 nM -0.711840953129468 0.229650198778626 no 2599 0.238281634841837 3814 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2095 5432005 200 µM -0.7142208053772 0.228869655442528 no 2600 0.237545326836018 3709 783734 SGTC_1840 st055363 71 µM -0.714319217765327 0.228837410263506 no 2601 0.237514905709033 3677 676033 SGTC_1140 3229-1848 2.98 µM -0.714993024812052 0.228616703430659 no 2602 0.23730667668297 3720 2849525 SGTC_3290 9121031 71.43 µM -0.71548379406052 0.228456026266037 no 2603 0.237155075613813 3703 17014854 SGTC_1693 xanthone 101.9 µM -0.71624961004771 0.228205425979513 no 2604 0.236918617566451 3761 7020 An insecticide. SGTC_658 3253-0951 102 µM -0.716793778775253 0.22802744996014 no 2605 0.236750675487602 3713 1184878 SGTC_1648 st011736 69.8 µM -0.718923377380866 0.227331693775784 no 2606 0.236094065839479 3730 2855514 SGTC_253 dyclonine 31.25 µM -0.719371874509112 0.227185318951833 no 2607 0.235955910722877 3782 3180 An oral anasthetic. SGTC_256 clotrimazole 625 nM -0.721711653355462 0.226422553552344 no 2608 0.235235887954605 3686 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_717 1532-0246 73.2 µM -0.721727351816306 0.226417440759836 no 2609 0.235231061150278 3712 9561992 SGTC_2513 baicalein 25.65 µM -0.723349601882494 0.22588944579457 no 2610 0.234732562997704 3705 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2581 avocatin a 64 µM -0.724655509202869 0.225464917450116 no 2611 0.234331697912189 3734 6710728 A skin care supplement. SGTC_585 0kpi-0023 191 µM -0.726682567234792 0.224806850693856 no 2612 0.233710217505422 3657 64601 SGTC_970 1315-0089 19.5 µM -0.726839616894781 0.224755911384158 no 2613 0.233662105454491 3681 6811083 YLR033W RSC58 SGTC_1962 st076595 64.5 µM -0.726911264940366 0.224732674399745 no 2614 0.233640157951151 3738 279619 SGTC_1098 clofazimine 15.1 µM -0.729246702207389 0.223975988807784 no 2615 0.23292538404622 3774 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2673 kobusone 100 µM -0.731418137868047 0.223273740528589 no 2616 0.23226189491292 3765 6710676 An epoxy ketone and protein crosslinker. SGTC_1469 k284-2957 126 µM -0.73372811142001 0.222528066268334 no 2617 0.231557230960182 3736 23884841 SGTC_1999 st074831 12.5 µM -0.735004901830761 0.222116520251117 no 2618 0.231168254406393 3716 17112523 SGTC_1663 st014140 55.4 µM -0.736785168890013 0.221543415150802 no 2619 0.230626501871202 3796 4207120 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.740173639724067 0.220454934397967 no 2620 0.229597320117938 3782 65057 A dermal irritant. YDR527W RBA50 SGTC_1068 loratadine 26.9 µM -0.740528502014799 0.22034111931436 no 2621 0.229489686674598 3771 3957 A H1 histamine antagonist. SGTC_1258 0671-0043 57.1 µM -0.741403845734564 0.220060514147071 no 2622 0.229224306704404 3758 4298767 SGTC_206 4546-0025 72.014 µM -0.742110404941116 0.219834165098607 no 2623 0.229010223093863 3754 6620745 YIL048W NEO1 SGTC_34 0469-0683 81.75 µM -0.742260928131346 0.219785961669155 no 2624 0.228964629881908 3733 3690923 SGTC_432 NS 1619 61.3 µM -0.742342899657133 0.219759713723447 no 2625 0.228939802991871 3803 4552 A K+/calcium channel activator. SGTC_2755 lomerizine 42.69 µM -0.742421235023603 0.219734631787037 no 2626 0.228916078804787 3739 3949 A calcium channel blocker. SGTC_340 k038-0059 454 µM -0.742658750496125 0.219658592557111 no 2627 0.228844154703507 3740 23733424 SGTC_2959 9079155 11 µM -0.743883256056645 0.21926681388394 no 2628 0.228473552980115 3737 16189457 SGTC_2870 9038528 12.99 µM -0.744770073505963 0.218983328941719 no 2629 0.228205364634855 3721 6463316 SGTC_2541 muurolladie-3-one 83.07 µM -0.745906592862169 0.218620331294312 no 2630 0.227861921173626 3764 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2914 7968218 45.32 µM -0.746036396453925 0.218578894836713 no 2631 0.227822714491039 3728 2977111 SGTC_1447 4239-0816 81.9 µM -0.746193438385534 0.21852876928472 no 2632 0.227775285646351 3762 1341554 SGTC_978 1416-0512 87.4 µM -0.74878270078588 0.217703268267029 no 2633 0.226994094033219 3818 6814003 SGTC_679 0422-0091 41.4 µM -0.749374601418017 0.21751481321149 no 2634 0.226815727462755 3754 627384 YHR062C RPP1 SGTC_118 0083-0097 135.343 µM -0.749525387818899 0.217466819430848 no 2635 0.226770301305467 3807 5207356 SGTC_1579 chlormadinone acetate 49.4 µM -0.750420345103409 0.217182089458446 no 2636 0.226500790686429 3765 45114258 A steroidal progestin. SGTC_2743 auranofin 4.32 µM -0.751138937664658 0.216953625747514 no 2637 0.226284522131484 3704 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_94 0334-0113 514.748 µM -0.751319835316354 0.216896134453522 no 2638 0.226230097323353 3749 6795178 SGTC_2994 9053520 71.4286 µM -0.753308144919822 0.216264808082896 no 2639 0.225632382750742 3791 4647384 SGTC_93 0109-0045 59.227 µM -0.75395196817126 0.216060610118913 no 2640 0.225439031872087 3840 88733 SGTC_2362 9071156 126 µM -0.753959042979737 0.216058366860417 no 2641 0.225436907710054 3762 653133 SGTC_1231 0242-0792 125 µM -0.75499797998145 0.215729090396367 no 2642 0.225125097129148 3767 3707635 SGTC_622 1348-1566 26.3 µM -0.75512859738255 0.215687713644424 no 2643 0.225085912928174 3814 7340407 SGTC_981 1488-1094 54.9 µM -0.755845896138991 0.215460571023466 no 2644 0.224870797793039 3740 3449522 SGTC_2044 5102272 200 µM -0.756885548405725 0.215131597107301 no 2645 0.224559217062433 3755 592666 SGTC_2926 9010726 65.15 µM -0.757341488190311 0.214987417535436 no 2646 0.224422650549149 3784 2994293 SGTC_2200 6600604 21.907 µM -0.758573482252945 0.214598110959462 no 2647 0.22405387028005 3730 2904777 SGTC_1862 st057513 3.81 µM -0.758993652108187 0.21446543226043 no 2648 0.223928177049576 3754 5393163 SGTC_2476 5806916 10.51 µM -0.760993893505606 0.213834462457672 no 2649 0.223330357303831 3699 2870194 SGTC_920 mycophenolic acid 780.421 nM -0.762319075699149 0.213417033920589 no 2650 0.222934795766313 3800 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2324 6149169 200 µM -0.762973826277765 0.213210964832013 no 2651 0.222739502761064 3721 2888231 SGTC_2973 9094665 17.96 µM -0.763677646966789 0.212989581411069 no 2652 0.222529682348052 3823 25237061 YIL048W NEO1 SGTC_811 0416-0114 265 µM -0.767052012437159 0.21193005558432 no 2653 0.22152529584853 3821 6612453 SGTC_2586 curcumin 80 µM -0.767325076849334 0.211844450427768 no 2654 0.221444131179388 3796 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_419 nsc-638432 893 µM -0.767501311168439 0.211789212058536 no 2655 0.221391756962338 3761 368090 SGTC_1562 morin hydrate 59.1 µM -0.769612741697627 0.211128067094967 no 2656 0.220764822247599 3833 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1428 4049-0204 61.7 µM -0.76977524625892 0.211077232779778 no 2657 0.220716612891361 3831 X1428 SGTC_2968 9090663 33.37 µM -0.76981139972966 0.211065924307158 no 2658 0.220705888255197 3781 25236811 SGTC_418 lividomycin a 100 µM -0.770288521575666 0.210916718259031 no 2659 0.220564381862715 3779 72394 An antibiotic. SGTC_1400 3771-8998 51.5 µM -0.771588209098166 0.210510592424032 no 2660 0.220179179965988 3709 670767 SGTC_1295 1013-0063 9.78 µM -0.771741273984527 0.210462792997352 no 2661 0.220133839942864 3778 6826038 SGTC_1080 nisoldipine 24.4 µM -0.772236326381993 0.210308240615752 no 2662 0.219987234968664 3778 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1011 4112-3381 17.4 µM -0.774110259957257 0.209723813712467 no 2663 0.219432795324223 3881 2877139 SGTC_2475 5812728 15.03 µM -0.776379346088385 0.209017429644399 no 2664 0.218762517980291 3786 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2289 7946404 165.07 µM -0.776808812884581 0.208883891186768 no 2665 0.218635788249858 3821 1246120 YPR165W RHO1 SGTC_1759 st043059 70 µM -0.777507347872858 0.208666796028729 no 2666 0.21842975050369 3806 669426 SGTC_511 blebbistatin 171 µM -0.779582397116194 0.208022683814242 no 2667 0.217818360230044 3854 3476986 A myosin inhibitor. SGTC_2948 9070189 9.45 µM -0.782522898134954 0.207111941173495 no 2668 0.216953666852311 3707 6473636 YDL196W YDL196W SGTC_1279 0874-0590 65.2 µM -0.783174023830547 0.206910591607591 no 2669 0.216762463351929 3851 3523074 SGTC_291 SEC14.278 35.5 µM -0.783703616424684 0.206746909555905 no 2670 0.216607020012201 3785 1068044 SGTC_2600 tangeritin 87.95 µM -0.785045910138544 0.206332388188539 no 2671 0.216213325716204 3765 68077 A bioactive flavone. SGTC_2191 5911152 200 µM -0.786580353858894 0.205859131737171 no 2672 0.215763781827884 3815 2875902 SGTC_1438 4092-1045 4 µM -0.787432809518723 0.205596494015396 no 2673 0.215514273330732 3792 1351342 SGTC_489 paxilline 115 µM -0.788522835290171 0.20526095197041 no 2674 0.215195473459755 3750 105008 A toxic potassium channel blocker. SGTC_14 0354-0009 295 µM -0.789619279707122 0.204923762510905 no 2675 0.214875072645603 3877 1713507 SGTC_1461 k072-0203 53.8 µM -0.791205184317144 0.204436632495893 no 2676 0.214412133349948 3750 5418714 SGTC_1393 3470-5649 58.2 µM -0.791446854490822 0.204362461108917 no 2677 0.214341638693685 3785 4108395 SGTC_194 1486-1323 56.904 µM -0.791966099970477 0.204203152829448 no 2678 0.214190221538224 3851 5178754 SGTC_616 4092-0450 108 µM -0.79223021382853 0.20412214916656 no 2679 0.214113227190628 3861 787165 SGTC_440 fluspirilene 35.1 µM -0.792366617112356 0.204080321805052 no 2680 0.214073469277368 3941 3396 An atypical antipsychotic. SGTC_1204 4049-0315 18.3 µM -0.793277047099326 0.203801273951896 no 2681 0.213808213322755 3927 588402 SGTC_2853 9015042 58.44 µM -0.793512582425107 0.203729119147902 no 2682 0.213739620719448 3765 6457456 SGTC_1092 toremifene 6.32 µM -0.793767796418482 0.203650953099031 no 2683 0.213665311764132 3809 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3289 9119912 71.43 µM -0.795617734240975 0.203084895427911 no 2684 0.213127127808511 3823 17014829 SGTC_3247 9135149 49.47 µM -0.798232088425083 0.202286539793895 no 2685 0.212367909710106 3816 8934436 YOR116C RPO31 SGTC_2596 sinensetin 100 µM -0.798950652199558 0.202067438471438 no 2686 0.212159513352299 3862 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1292 0kpi-0043 232 µM -0.799323345381994 0.201953854450528 no 2687 0.21205147276042 3854 3333905 SGTC_630 4356-0227 183 µM -0.80154812263341 0.201276614501675 no 2688 0.211407198317827 3811 779312 SGTC_1879 gemcitabine 100 µM -0.801569924035054 0.201269984724668 no 2689 0.211400890515725 3824 60750 A nucleoside analog which inhibits DNA replication. SGTC_854 0422-0053 192 µM -0.801596955005608 0.201261764824564 no 2690 0.211393069794897 3869 3596728 SGTC_3338 9144300 39.5675 µM -0.80520061291774 0.200167724336699 no 2691 0.210351961422636 3874 4901274 SGTC_748 act1.228 77.9 µM -0.805443604442651 0.200094082992734 no 2692 0.210281868895714 3784 4421505 YNR035C ARC35 SGTC_619 1652-1634 108 µM -0.806991750780515 0.199625282178231 no 2693 0.209835617909462 3804 5400454 SGTC_1046 2001-0062 216 µM -0.808668918833412 0.199118158303703 no 2694 0.209352805366555 3747 739778 SGTC_1397 3532-0190 20.1 µM -0.80983097238594 0.198767244752026 no 2695 0.209018664475677 3759 5322280 SGTC_124 0136-0217 7.121 µM -0.810131955559119 0.198676415558207 no 2696 0.20893216997468 3917 3976905 SGTC_2924 9010168 62.78 µM -0.810310172545137 0.198622645928808 no 2697 0.208880965126914 3944 2993929 SGTC_3135 9127742 49.47 µM -0.811931243352175 0.198133957735241 no 2698 0.208415542796996 3928 3643468 SGTC_487 nimodipine 119 µM -0.817350472668425 0.196505553551746 no 2699 0.206864085308611 3737 4497 L-type voltage-gated calcium channels inhibitor SGTC_780 0109-0199 192 µM -0.818336403113872 0.196210169271764 no 2700 0.206582562542412 3919 610414 SGTC_2698 st077697 67.5 µM -0.818806896723457 0.196069304561973 no 2701 0.206448297729243 3831 3154499 SGTC_2399 5884133 200 µM -0.819139016891104 0.195969905486308 no 2702 0.206353551696958 3874 722445 SGTC_1912 st060209 90.8 µM -0.819296285821486 0.195922847689437 no 2703 0.206308695580341 3890 688787 SGTC_1984 st072354 53.1 µM -0.81999982750183 0.195712418849221 no 2704 0.206108102754067 3772 5762938 SGTC_580 1123-0028 41 µM -0.821766542656023 0.195184600693913 no 2705 0.205604889482754 3928 1677248 YPR107C YTH1 SGTC_3101 9120531 49.47 µM -0.821867269904465 0.19515453383406 no 2706 0.205576221345486 3871 24824904 SGTC_584 0986-0246 15.4 µM -0.822229479066548 0.195046438467031 no 2707 0.205473152049271 3958 53315 YDR232W HEM1 SGTC_1237 0330-0133 46.1 µM -0.823923042286569 0.194541505509835 no 2708 0.204991643413919 3806 X1237 YHR072W ERG7 SGTC_160 3453-0671 289.699 µM -0.833872248394997 0.191591261800711 no 2709 0.202176488524963 3935 5322268 SGTC_2826 7992541 19.48 µM -0.83537251472393 0.191148776937471 no 2710 0.201754000077816 3918 2985066 SGTC_3024 9090631 49.47 µM -0.836208705726789 0.190902424985775 no 2711 0.201518750838429 3825 25236383 SGTC_1189 1431-2119 7.28 µM -0.836346747959452 0.190861774818864 no 2712 0.201479930631023 3900 3107275 SGTC_1176 0848-0131 83.3 µM -0.84110961376544 0.189462478014851 no 2713 0.200143264899579 3946 6769040 SGTC_966 1300-0360 30.2 µM -0.843063779535368 0.188890188922918 no 2714 0.199596387260211 3883 70588 SGTC_629 3448-6466 76.7 µM -0.846228968190141 0.187965507159414 no 2715 0.198712512359054 3884 573744 SGTC_1948 st076329 66.6 µM -0.846442789306904 0.187903142153264 no 2716 0.19865288830889 3777 24208413 SGTC_1897 st060201 15 µM -0.847305171331605 0.187651741695812 no 2717 0.198412522481078 3947 611878 SGTC_1446 4239-0190 62 µM -0.848344230475801 0.187349112723926 no 2718 0.198123145866011 3913 1340085 SGTC_2940 9060638 45.86 µM -0.848775122370114 0.187223702770073 no 2719 0.198003217821269 3914 4027022 SGTC_641 4092-0595 30 µM -0.849786622855999 0.186929512231286 no 2720 0.1977218641227 3931 786260 SGTC_96 0929-0093 37.281 µM -0.854466713970625 0.185572054787001 no 2721 0.196423222430586 3885 6991579 SGTC_1695 st026914 34.495 µM -0.855686878717005 0.18521915460715 no 2722 0.196085499964166 3857 3289191 SGTC_2831 7999036 19.48 µM -0.857276131408835 0.184760130977785 no 2723 0.195646148219001 3990 2988270 SGTC_3299 9121982 43.1275 µM -0.857457014133589 0.184707931506782 no 2724 0.195596180776762 3978 17594604 YPL160W CDC60 SGTC_3198 9112019 49.47 µM -0.857902917868742 0.184579290947863 no 2725 0.195473036445687 3962 45595555 SGTC_2773 thioridazine 9.09 µM -0.859265238477433 0.184186614858002 no 2726 0.195097098913665 3922 5452 An antipsychotic. SGTC_353 1988-1175 58.3 µM -0.859566718311654 0.184099786447026 no 2727 0.195013963839638 3762 2788357 SGTC_2418 pentamidine 31.67 µM -0.862561538004389 0.183238640625149 no 2728 0.194189292476102 3897 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_527 4476-4215 268 µM -0.862891758559284 0.183143841322256 no 2729 0.194098491175421 3906 4418754 SGTC_88 0180-0332 8.668 µM -0.86384866130252 0.182869307694148 no 2730 0.19383551612642 3988 3101745 SGTC_2986 9022445 71.43 µM -0.865202527710312 0.182481324961438 no 2731 0.193463819136369 3926 6459286 SGTC_3273 9137859 49.47 µM -0.865355343849626 0.182437564166793 no 2732 0.193421891585766 3983 2377234 SGTC_2505 galangin 7.89 µM -0.865765015619307 0.182320281928886 no 2733 0.193309518941435 3827 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_927 2425-1185 123 µM -0.868299743861492 0.181595679163662 no 2734 0.192615131182755 3883 730375 SGTC_2519 cryptotanshinone 88.04 µM -0.869022429948849 0.181389415514826 no 2735 0.192417431254618 3900 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_207 4185-0010 4.486 µM -0.870701506182407 0.180910752732271 no 2736 0.191958577942905 3987 3761753 SGTC_1791 st048313 56.1 µM -0.871411973966584 0.180708454641798 no 2737 0.191764625082187 3908 1204976 SGTC_85 0868-0259 160.055 µM -0.872293078587556 0.180457766645041 no 2738 0.191524256280718 3871 83173 SGTC_176 1486-1328 72.834 µM -0.872978983805131 0.180262767013811 no 2739 0.191337266476583 3996 22310231 SGTC_678 1218-2179 85.9 µM -0.873222912405161 0.180193451146757 no 2740 0.191270794238167 3903 6820081 YOR116C RPO31 SGTC_2740 felodipine 17.08 µM -0.873288355823765 0.180174857292152 no 2741 0.191252962860482 3919 3333 L-type calcium channel blocker SGTC_3074 9116018 49.47 µM -0.874527700120758 0.179822960840739 no 2742 0.190915470944633 3983 17027303 SGTC_1425 4048-4433 7.33 µM -0.874853268715383 0.179730591322528 no 2743 0.190826874394472 3980 23734946 SGTC_1936 st074407 74.3 µM -0.876819083941843 0.17917348867532 no 2744 0.190292455895911 3982 809813 SGTC_3114 9122766 49.47 µM -0.877220225114704 0.179059940760079 no 2745 0.190183516345457 3942 17176985 SGTC_677 0929-0063 136 µM -0.878270729410086 0.178762797253745 no 2746 0.189898408217692 3910 1539583 SGTC_1281 0884-0031 11.8 µM -0.87884537596054 0.178600385327367 no 2747 0.189742559700067 3951 1548255 SGTC_593 1203-0218 61.7 µM -0.879130346740024 0.178519878726563 no 2748 0.189665302641649 3988 3666956 SGTC_1102 cgs 12066b 26.1 µM -0.879543316441421 0.178403251942679 no 2749 0.189553378754469 3955 6438352 A 5-HT1B full agonist. SGTC_3150 9097574 49.47 µM -0.879737650986852 0.178348386531913 no 2750 0.189500723875039 3964 17217476 SGTC_681 1642-0006 26.6 µM -0.882297611154595 0.177626639664509 no 2751 0.188807943970671 3955 4446530 SGTC_2477 5967686 25.23 µM -0.884055312983946 0.177132147677656 no 2752 0.188333177252915 3936 776118 SGTC_2652 actinonin 100 µM -0.884144302069709 0.177107135641801 no 2753 0.188309160323782 3937 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2688 kanamycin b 96.69 µM -0.884747244689534 0.176937726191973 no 2754 0.188146484186769 4025 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_90 0870-0863 4.608 µM -0.884814983097899 0.176918700057676 no 2755 0.18812821353566 3942 1738164 SGTC_2122 5258151 111.688 µM -0.886688426236133 0.176393006143374 no 2756 0.187623335613707 3944 2173356 SGTC_285 1486-1325 46 µM -0.887030615464517 0.176297093636401 no 2757 0.187531208854674 3987 22310230 SGTC_3154 9100113 49.47 µM -0.888898224168762 0.175774201747811 no 2758 0.187028889966024 3989 25237525 SGTC_2965 9082772 38.63 µM -0.889388224613339 0.175637174595772 no 2759 0.186897235616181 3962 16459634 SGTC_2474 5321570 43.32 µM -0.889590340916999 0.175580673102063 no 2760 0.186842947292692 3969 2841384 SGTC_2539 epi(13)torulosol 80 µM -0.890525289790595 0.175319458597097 no 2761 0.186591947566305 4005 6708597 SGTC_2022 5136654 200 µM -0.891283893110694 0.175107694285319 no 2762 0.186388443706425 4016 1713771 SGTC_2204 7233102 200 µM -0.893238363094017 0.174562851389346 no 2763 0.185864768948111 3841 2172480 SGTC_2484 5809818 12.04 µM -0.89379113493024 0.174408952022425 no 2764 0.185716826625675 3934 2870548 SGTC_343 4130-2827 29.8 µM -0.894402242579461 0.174238911502859 no 2765 0.18555335651763 3997 1118244 SGTC_2915 7971052 15.16 µM -0.898433232833466 0.173119930366858 no 2766 0.184477312876127 3841 5741558 SGTC_1827 berberine 7.24 µM -0.899663614252183 0.172779296911707 no 2767 0.184149646181248 3910 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_719 2810-4230 27.3 µM -0.900044267168961 0.172673999007391 no 2768 0.184048346740682 3966 721079 SGTC_2142 5622915 118.518 µM -0.900155457451704 0.172643248778543 no 2769 0.184018763305625 3977 5322196 SGTC_1729 st035615 45.989 µM -0.901702085665054 0.172215883089052 no 2770 0.183607572392075 4007 17385451 SGTC_1573 oleylamine 1.06 µM -0.902535040602343 0.171986000165152 no 2771 0.183386358061257 3971 5356789 An amine of the fatty acid oleic acid. SGTC_1484 3473-2379 286 µM -0.904685703641258 0.171393356197402 no 2772 0.18281595853252 4078 671917 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.904994486036868 0.171308374365444 no 2773 0.182734154178081 3972 3256 An antibiotic and ribosome inhibitor. SGTC_2329 6138490 200 µM -0.905063268824494 0.171289447916287 no 2774 0.182715934971103 4114 720019 SGTC_2748 diazoxide 86.69 µM -0.907413490253138 0.170643558253639 no 2775 0.182094089108294 3981 3019 A potassium channel activatior. SGTC_772 k072-0172 35.3 µM -0.909450778252071 0.170084932438355 no 2776 0.181556114288667 4024 5861980 SGTC_1915 st067105 30.6 µM -0.911168900461672 0.169614734162423 no 2777 0.181103193759074 3951 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_791 1348-1292 225 µM -0.913355713331007 0.169017476690629 no 2778 0.180527744746736 3957 5437054 SGTC_2391 6285546 200 µM -0.913709853835596 0.168920881863781 no 2779 0.180434662438867 3968 846083 SGTC_1637 st007924 17.4 µM -0.915687890270528 0.168382008041163 no 2780 0.17991530915172 3931 683336 SGTC_145 3737-0113 38.366 µM -0.917051985150421 0.168011034303992 no 2781 0.179557699898442 3966 6849351 SGTC_2701 st077767 14.721 µM -0.917687767699928 0.167838309303868 no 2782 0.179391176751467 3961 5721188 SGTC_1304 1165-0502 251 µM -0.920798560921495 0.166994839383405 no 2783 0.178577803234461 3999 767425 SGTC_976 1348-1067 47.6 µM -0.920958414031069 0.166951570298613 no 2784 0.178536069565979 4020 5310671 YGL099W LSG1 SGTC_651 3253-0966 34.4 µM -0.921190903907923 0.166888652780174 no 2785 0.178475383210512 4017 781462 SGTC_459 nigericin 15.3 µM -0.922027895938295 0.166662268675139 no 2786 0.178257012512519 4058 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1649 st011737 51.3 µM -0.92279934919915 0.166453786657589 no 2787 0.17805589002656 3988 1761035 SGTC_2212 7123476 200 µM -0.923361056912741 0.166302093472023 no 2788 0.177909539506563 3950 1085715 SGTC_2119 5528445 120.635 µM -0.923445811921649 0.166279212529811 no 2789 0.177887463543727 4016 791935 SGTC_166 k072-0058 166.424 µM -0.923793481049124 0.166185375080152 no 2790 0.177796924961325 3923 5846229 SGTC_1016 4226-1401 38 µM -0.927205013021226 0.165266402535317 no 2791 0.176910050272391 3971 2901613 SGTC_382 3229-0966 23.2 µM -0.928436073849363 0.164935597744109 no 2792 0.176590706711651 4024 5722370 SGTC_205 1486-1330 71.903 µM -0.928445728657661 0.164933005045887 no 2793 0.176588203645918 4010 4118834 SGTC_2544 sphondin 68.51 µM -0.928971545904182 0.164791842160772 no 2794 0.176451916325001 4000 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1121 fusaric acid 630.51 nM -0.930605618119513 0.164353652637459 no 2795 0.17602880364863 3983 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2368 9071271 200 µM -0.931197338027941 0.164195164685749 no 2796 0.175875747310119 4013 27209959 SGTC_1064 honokiol 6.76 µM -0.931301043828811 0.164167398038884 no 2797 0.175848931088423 4018 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1472 k841-0093 193 µM -0.931861505602864 0.164017390246431 no 2798 0.175704051833648 4097 X1472 SGTC_2711 st079103 59.1 µM -0.933400826154352 0.163605848227116 no 2799 0.17530652700034 3967 54693780 SGTC_3330 9141424 71.43 µM -0.93376324420726 0.163509052256284 no 2800 0.175213016648439 4087 27261020 SGTC_2639 lactacystin 53 µM -0.934061713631338 0.163429363857169 no 2801 0.175136029946653 4062 3870 A proteasome inhibitor. SGTC_646 4092-0839 27.3 µM -0.936556679739309 0.162764219428197 no 2802 0.174493322131786 4064 877796 SGTC_2449 5812982 45.77 µM -0.936629297560474 0.162744886315963 no 2803 0.174474638111734 3961 776185 SGTC_2378 9074213 121.43 µM -0.940897493390196 0.161611184467641 no 2804 0.173378696146194 3993 657714 SGTC_2148 5546263 113.568 µM -0.942658121008543 0.161145036711803 no 2805 0.172927900394171 4004 792097 SGTC_2523 spermine 47.74 µM -0.942748528797002 0.16112112384508 no 2806 0.172904772322431 4034 1103 A DNA binding polyamine. SGTC_1852 st056254 31.4 µM -0.943349033539153 0.160962349065767 no 2807 0.172751201552635 3954 442583 SGTC_2041 5107442 45.335 µM -0.944120977384887 0.160758395480284 no 2808 0.172553915367201 4067 793005 SGTC_1676 st018489 23.4 µM -0.947653191120673 0.159827310651438 no 2809 0.171653018939885 4056 3696235 SGTC_1173 0443-0020 122 µM -0.949272789834928 0.159401569482205 no 2810 0.171240944454013 4022 5331295 SGTC_3351 9150312 21.596 µM -0.949822911721921 0.159257128961705 no 2811 0.171101120973794 3945 4904905 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.950645685289646 0.159041260777573 no 2812 0.170892134425951 4070 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2397 5161689 200 µM -0.951918994853787 0.158707565151916 no 2813 0.170569032717352 4081 2259942 SGTC_2385 9074692 200 µM -0.953915106132197 0.158185369734365 no 2814 0.170063308141299 4054 17046906 SGTC_1441 4106-0040 13 µM -0.954527319180957 0.158025437116485 no 2815 0.169908393735323 4020 2904180 SGTC_1530 rhein 70.4 µM -0.956993662811374 0.157382212835941 no 2816 0.169285226817926 4096 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_364 0083-0097 67.7 µM -0.957029168696819 0.157372965457887 no 2817 0.169276266331521 4139 5207356 SGTC_120 rhodamine 6G 52.259 µM -0.957716262837248 0.157194084633417 no 2818 0.169102926931792 4057 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1638 st008370 60.6 µM -0.959788996996219 0.156655271097835 no 2819 0.168580710556476 3997 24207134 SGTC_82 0054-0107 293.755 µM -0.961885974003091 0.156111394139602 no 2820 0.168053442438449 3995 3104697 SGTC_2910 7948405 25.97 µM -0.961916020990812 0.156103610134059 no 2821 0.168045895083862 3960 2971328 SGTC_2619 obliquin 87.91 µM -0.962780748818724 0.155879702392382 no 2822 0.167828781842909 3986 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1481 3346-2004 36 µM -0.96597661404968 0.155054021178133 no 2823 0.167027941620619 4089 2770522 SGTC_631 k072-0230 41.5 µM -0.967442162689603 0.154676350760665 no 2824 0.166661520641075 4075 5773147 SGTC_2470 5664817 21.68 µM -0.968082460050752 0.154511537734151 no 2825 0.166501594480021 4071 2859561 SGTC_56 0957-0365 83.25 µM -0.973402083340258 0.153146752388419 no 2826 0.165176751945661 4048 6752360 SGTC_2472 5377652 49.4 µM -0.973858586236662 0.153030006851051 no 2827 0.165063379486557 4132 1610903 SGTC_1777 st045864 34.765 µM -0.978781349373646 0.151774813925736 no 2828 0.163844013469119 4038 4691462 SGTC_3075 9116269 49.47 µM -0.97914353491247 0.151682735790766 no 2829 0.163754531749557 4101 17015205 YNL244C SUI1 SGTC_3078 9116413 49.47 µM -0.982903209961213 0.150729109962856 no 2830 0.162827538924604 3987 17177322 SGTC_3286 9117135 37.221 µM -0.983538945838627 0.150568253664485 no 2831 0.162671128604349 4040 3438150 SGTC_2325 6158266 200 µM -0.984600166660968 0.15029999437252 no 2832 0.162410253891905 4107 3623240 SGTC_785 1270-0111 65.3 µM -0.986498702626786 0.149820870528512 no 2833 0.161944225787473 4005 6741994 SGTC_2675 theaflavin digallate 100 µM -0.986736710725246 0.149760877580009 no 2834 0.161885864142062 4019 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1949 st076024 69.1 µM -0.987429509863164 0.149586340028701 no 2835 0.161716061803562 4003 2921930 SGTC_1192 1488-0095 21.4 µM -0.987463242144073 0.149577845289675 no 2836 0.161707797119013 4130 915875 SGTC_15 0266-0086 27.098 µM -0.988207445792079 0.149390515731278 no 2837 0.161525531175128 4133 1712902 YIL048W NEO1 SGTC_3182 9108849 49.47 µM -0.988921660863041 0.14921088217881 no 2838 0.16135073585938 4110 17133045 SGTC_2882 9058044 58.44 µM -0.989344694270775 0.149104552311467 no 2839 0.161247261856715 4109 18076804 SGTC_3158 9100007 49.47 µM -0.992442819183281 0.148327378336416 no 2840 0.160490779975967 4111 19297233 SGTC_21 0849-0113 22.993 µM -0.994863466930163 0.147722040506418 no 2841 0.159901336620239 4045 1560156 SGTC_2777 climbazole 1.536 µM -0.995532443136067 0.14755504004442 no 2842 0.159738686649242 3956 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.99595860607991 0.147448720455989 no 2843 0.159635128978552 4128 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2112 5488546 200 µM -0.99749780872225 0.147065146106965 no 2844 0.159261468451686 4047 600757 SGTC_3033 9090887 49.47 µM -0.999824430094348 0.146486615525835 no 2845 0.15869774043808 4115 19325384 SGTC_2654 protoveratrine a 100 µM -1.00121046947994 0.146142694291305 no 2846 0.158362533026496 4074 5702278 A heart drug and vasodilator. SGTC_559 1550-0661 158 µM -1.00192951228251 0.145964490335894 no 2847 0.158188818876849 4149 5830875 SGTC_908 3448-7491 47.7 µM -1.00206629232293 0.145930607993927 no 2848 0.158155788235386 4101 1203031 SGTC_2887 9044784 58.44 µM -1.0077912052042 0.144517205661476 no 2849 0.156777354448883 4068 6465546 SGTC_782 0083-0095 30.5 µM -1.01107786517365 0.143709955727864 no 2850 0.15598958178065 4081 3591729 An indicator and reagent. SGTC_22 0964-0034 14.468 µM -1.01196142369953 0.143493461273017 no 2851 0.155778249221002 4124 138402 SGTC_67 0335-0847 266 µM -1.01443887676637 0.142887596523937 no 2852 0.155186690754121 4243 4552207 YOR254C SEC63 SGTC_19 0279-0214 38.434 µM -1.01568748182073 0.142582904520031 no 2853 0.154889115517139 4180 3566274 YBR002C RER2 SGTC_2749 bexarotene 57.39 µM -1.01636530438393 0.142417682371884 no 2854 0.154727730616478 4150 82146 An retinoic acid receptor inhibitor. SGTC_926 2268-1401 59.4 µM -1.01649287995088 0.142386599769359 no 2855 0.154697368177393 4072 2931578 SGTC_1850 st056238 17 µM -1.01796067872203 0.142029314362303 no 2856 0.15434832157918 4123 5393177 SGTC_3053 9095903 49.47 µM -1.01921344781918 0.141724851009707 no 2857 0.154050821847099 4205 17174018 SGTC_251 melphalan 456.522 µM -1.02212774513481 0.141018294010333 no 2858 0.153360221519072 4127 460612 A DNA alkylator. SGTC_1474 0330-0125 5.35 µM -1.02538035633092 0.140232540094126 no 2859 0.152591876629366 4125 X1474 SGTC_2765 myclobutanil 7.74 µM -1.02585602560081 0.140117879382736 no 2860 0.152479726554104 4143 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_3167 9103034 49.47 µM -1.02670869675624 0.1399125013204 no 2861 0.152278826471336 4165 5127859 SGTC_2296 7971656 126.45 µM -1.02976142157075 0.139178886832427 no 2862 0.151561007309803 4171 666570 SGTC_10 0279-0212 42.575 µM -1.03055463197925 0.138988696008884 no 2863 0.151374860212464 4099 39851 YBR002C RER2 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.03072788188268 0.1389471788308 no 2864 0.151334222933465 4121 75037 A free radical scavenger. SGTC_1774 st048371 48.465 µM -1.03143966075715 0.138776698513253 no 2865 0.151167345119787 4113 4242727 SGTC_393 acivicin 6.25 µM -1.03293653723359 0.138418642067507 no 2866 0.150816799377421 3978 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_776 4476-4378 112 µM -1.03399122748712 0.138166736041617 no 2867 0.150570132173367 4180 2892008 SGTC_2459 5811157 9.22 µM -1.03585162485207 0.137723154409593 no 2868 0.150135684425747 4097 2870684 YBR192W RIM2 SGTC_733 4069-0007 56.1 µM -1.04431016248291 0.135718614340619 no 2869 0.14817095629545 4138 5717425 YNL287W SEC21 SGTC_3007 9078383 71.4286 µM -1.04443829575677 0.135688403227629 no 2870 0.148141326702436 4129 6496995 SGTC_268 camptothecin 39.6153 µM -1.04564520998109 0.135404064453017 no 2871 0.147862433898377 4113 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1470 k295-0292 231 µM -1.04772748022269 0.13491445981478 no 2872 0.147382091407879 4223 5045612 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.04870567831293 0.134684875655134 no 2873 0.147156800009544 4122 676296 Flavone; oxidizing agent. SGTC_2512 diallyl trisulfide 49.23 µM -1.04936324788406 0.134530694136612 no 2874 0.147005483249797 4166 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2981 9013952 38.96 µM -1.05018381641398 0.134338463950745 no 2875 0.146816804343 4106 2996344 SGTC_3205 9113483 49.47 µM -1.05052224219458 0.134259237724073 no 2876 0.146739035137795 4191 17018033 SGTC_3171 9103192 49.47 µM -1.05086754460579 0.134178434743641 no 2877 0.146659714196146 4198 13018434 SGTC_2489 cantharidin 73.42 µM -1.05171614342512 0.133979999116477 no 2878 0.146464901076011 4097 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2745 rifampicin 24.3 µM -1.05468136030849 0.133288199210634 no 2879 0.145785539731261 4180 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1683 st010134 710 nM -1.05501152927745 0.133211321482532 no 2880 0.145710025924781 4134 3818134 SGTC_2785 7756463 72.73 µM -1.05831933344367 0.132442804535352 no 2881 0.14495494082537 4115 2201551 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.05918059811978 0.13224320537772 no 2882 0.1447587696566 4165 5379071 SGTC_1220 1838-0075 193 µM -1.06035893472095 0.131970460483156 no 2883 0.144490668446744 4055 5529645 SGTC_2004 4023728 41.89 µM -1.06217397157986 0.131551100619837 no 2884 0.144078356878864 4130 360084 YDR527W RBA50 SGTC_1728 st035614 33.7865 µM -1.06383309718305 0.131168569153279 no 2885 0.143702157516412 4113 15945546 SGTC_1781 st038725 66.3 µM -1.06504895064801 0.130888727723351 no 2886 0.143426889376244 4138 4270275 YIL048W NEO1 SGTC_2127 5253358 187.912 µM -1.06532743790446 0.130824689076381 no 2887 0.143363890252144 4063 20612 SGTC_2390 9097792 176.6 µM -1.06604943719115 0.130658764896616 no 2888 0.143200647283242 4172 4497149 SGTC_2099 5377090 177.372 µM -1.06620722221103 0.130622523368701 no 2889 0.143164989047668 4166 2243829 SGTC_3098 9119039 49.47 µM -1.06863140087766 0.130066589119044 no 2890 0.142617896729799 4155 17161528 SGTC_2759 disulfiram 3.38 µM -1.06942755353935 0.129884366042536 no 2891 0.142438528577132 4063 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2145 5634607 200 µM -1.07072190914597 0.129588491901986 no 2892 0.142147244278697 4129 308662 SGTC_410 α-linolenic acid 100 µM -1.07151396788031 0.129407667231331 no 2893 0.141969196808696 4221 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1433 4060-0023 7.6 µM -1.07273633765311 0.129128947084882 no 2894 0.14169471582158 4180 3840627 SGTC_796 1234-0020 70.7 µM -1.07359032965676 0.12893447017548 no 2895 0.141503166844407 4096 46495034 SGTC_794 k038-0031 316 µM -1.07442444448504 0.12874471602267 no 2896 0.14131624574226 4145 6624242 SGTC_312 4092-0653 6.84 µM -1.07811483015581 0.127907509445141 no 2897 0.140491257082955 4101 1148278 SGTC_1835 st008666 49.2 µM -1.07918006300015 0.127666554214079 no 2898 0.14025373276611 4112 690455 SGTC_146 3448-8650 53.125 µM -1.08170625551547 0.127096392507661 no 2899 0.139691536332615 4156 2891488 YIL048W NEO1 SGTC_2198 6589944 200 µM -1.08246563247337 0.126925348021548 no 2900 0.139522839235734 4170 5290268 SGTC_1668 st014914 51.6 µM -1.08261037553482 0.12689276382304 no 2901 0.139490700006371 4177 2839556 SGTC_2028 5153890 36.43 µM -1.0832447761873 0.126750017818738 no 2902 0.139349894985706 4151 2830968 YPR165W RHO1 SGTC_438 sphingosine 6.67 µM -1.08362520761836 0.126664470883733 no 2903 0.139265504747773 4128 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_767 0929-0023 86 µM -1.08588100898482 0.126158038988009 no 2904 0.138765819990948 4183 1204563 SGTC_2827 7993847 71.43 µM -1.08611932197247 0.126104619795096 no 2905 0.138713102453906 4259 2985692 SGTC_3017 9080681 49.47 µM -1.0869758057598 0.12591276433115 no 2906 0.138523751146951 4197 16451914 SGTC_2172 5754775 163.918 µM -1.08965235799078 0.12531451933125 no 2907 0.137933154958414 4156 2263357 SGTC_3194 9111903 49.47 µM -1.0911973780716 0.124970091544203 no 2908 0.137593020680147 4223 17087251 SGTC_887 0885-0007 9.62 µM -1.09184683267714 0.124825507713993 no 2909 0.137450215095233 4259 5719458 SGTC_1133 3473-0247 50 µM -1.09207513365422 0.124774710337367 no 2910 0.137400039091147 4161 711311 SGTC_1353 1498-1206 8.11 µM -1.09279367212669 0.124614928525916 no 2911 0.13724220029127 4221 6756808 SGTC_744 1594-0068 283 µM -1.09974167925854 0.123077272341768 no 2912 0.135722344677868 4162 668392 SGTC_2340 7987427 183.45 µM -1.09996492245432 0.12302808812855 no 2913 0.135673702813503 4219 2239331 SGTC_843 0310-0051 143 µM -1.1012815065853 0.122738302849506 no 2914 0.135387078704149 4225 2065037 SGTC_1625 st003711 30.1 µM -1.10136236383265 0.122720521472301 no 2915 0.13536948938791 4269 24207034 YER133W GLC7 SGTC_2382 9035899 200 µM -1.10450565837531 0.122030677238668 no 2916 0.134686925189833 4192 6462679 SGTC_1169 aniline yellow 25.8 µM -1.10513474900486 0.121892941341691 no 2917 0.134550602750016 4121 6051 A DNA damaging agent. SGTC_819 1013-0258 27.7 µM -1.10537531522962 0.12184029957962 no 2918 0.134498497665327 4199 5753198 SGTC_2729 fluphenazine 10.66 µM -1.10612169724675 0.121677074630639 no 2919 0.134336924326677 4121 3372 An atypical antipsychotic. SGTC_1989 st071868 50.2 µM -1.10669476549304 0.121551855687597 no 2920 0.13421295964551 4194 16414057 SGTC_636 0kpi-0074 126 µM -1.10896845244029 0.121055933776568 no 2921 0.13372189583603 4205 616434 SGTC_541 4513-1321 94 µM -1.11819901481319 0.119057248635383 no 2922 0.13174100248839 4182 747515 SGTC_1052 3253-3998 198 µM -1.11999098605278 0.118671950970384 no 2923 0.13135880164647 4144 5450317 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.1219431784994 0.118253207205304 no 2924 0.130943300131953 4261 91467 include heat shock SGTC_1732 st034308 51.822 µM -1.12194885664569 0.118251990773041 no 2925 0.130942092930471 4079 830119 SGTC_1240 0356-0016 42.1 µM -1.12456979756353 0.117691449486943 no 2926 0.130385689044047 4185 4305613 SGTC_2290 7904846 200 µM -1.12513818880388 0.117570136061549 no 2927 0.130265240432424 4268 2962154 SGTC_1366 1683-0113 21.9 µM -1.1272936868635 0.117110886210842 no 2928 0.129809165353183 4221 708623 SGTC_139 0099-0334 718.624 µM -1.1293779628824 0.116668020993715 no 2929 0.129369212534815 4257 97690 SGTC_59 0330-0160 1.33 µM -1.13069959345264 0.116387818004468 no 2930 0.129090776264687 4179 4293482 SGTC_2276 7947513 42.08 µM -1.13137559449677 0.116244681622535 no 2931 0.128948519578747 4173 2105100 SGTC_3304 9125678 46.087 µM -1.13201087464184 0.116110281373024 no 2932 0.128814931268666 4155 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_835 0312-0010 67.2 µM -1.13210898417885 0.116089535096119 no 2933 0.128794309109115 4217 1626196 SGTC_2263 7948595 193.29 µM -1.13223290592217 0.116063334321818 no 2934 0.128768264619709 4224 2971371 SGTC_126 0417-1624 672.48 µM -1.13287246423201 0.11592817924109 no 2935 0.128633907479955 4274 41912 YDL195W SEC31 SGTC_665 3914-0008 307 µM -1.13315241160303 0.115869054353898 no 2936 0.128575127313057 4163 1069549 SGTC_333 3486-0131 40.1 µM -1.13337793256909 0.115821439898707 no 2937 0.128527788542995 4258 6744690 SGTC_1325 1431-0015 227 µM -1.13342404069748 0.115811706756941 no 2938 0.12851811154408 4233 1103340 SGTC_2536 dehydroabietamide 32.04 µM -1.13371878604958 0.11574950155385 no 2939 0.128456263457399 4317 3983547 SGTC_3277 9138724 49.47 µM -1.13408340146978 0.115672583302876 no 2940 0.128379782730129 4191 15943418 SGTC_599 1935-0052 86.5 µM -1.13437548242631 0.115610992916903 no 2941 0.128318539441711 4214 9557311 SGTC_296 1222-0039 74.9 µM -1.1373032738452 0.114994903756105 no 2942 0.127705763315102 4240 5984176 SGTC_880 0833-0487 87.2 µM -1.13769892385828 0.114911827354231 no 2943 0.127623111473259 4221 76075 SGTC_1072 oxiconazole 14.9 nM -1.13869761099627 0.114702318450941 no 2944 0.127414649761964 4214 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2866 9034245 58.44 µM -1.13899015627847 0.114640998539775 no 2945 0.12735362997196 4201 6462273 SGTC_2784 7567673 72.73 µM -1.14229896940267 0.113949067615702 no 2946 0.126664884747998 4193 3471247 SGTC_1460 k062-0059 9.15 µM -1.14343477410089 0.113712238329432 no 2947 0.126429060738612 4113 1373085 SGTC_2817 7995342 71.43 µM -1.14564995827708 0.113251354999804 no 2948 0.125970008623246 4238 18879975 SGTC_1408 3909-7976 48.8 µM -1.14584434554267 0.11321097517003 no 2949 0.125929781334779 4287 24152374 SGTC_605 1315-0399 119 µM -1.1464181080238 0.113091848096299 no 2950 0.125811096849076 4301 24020461 SGTC_518 1021-0119 62.6 µM -1.14646685708903 0.113081730726784 no 2951 0.125801016556311 4200 1097762 SGTC_1341 1486-1360 280 µM -1.146609228858 0.113052186621141 no 2952 0.12577158026084 4224 3976547 SGTC_1805 st050013 60.3 µM -1.1478225043995 0.112800638687116 no 2953 0.125520922525574 4183 4037144 SGTC_1063 disulfiram 1.84 µM -1.15317811060098 0.111695038434307 no 2954 0.124418643062104 4272 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1252 0493-0875 34.8 µM -1.15481379530196 0.111358921556614 no 2955 0.124083343298957 4213 3960963 SGTC_1747 st037496 66.6 µM -1.1556744064969 0.111182365502787 no 2956 0.123907180274891 4215 723305 SGTC_1739 st037196 92.5 µM -1.15660583392745 0.110991507307463 no 2957 0.123716718832645 4299 612214 SGTC_1155 4088-0394 48.2 µM -1.1568282850305 0.11094595973089 no 2958 0.123671261615298 4219 2326248 SGTC_1839 st053978 48 µM -1.15697243032323 0.110916452669768 no 2959 0.123641812201159 4250 3788398 SGTC_2775 cyproheptadine 69.59 µM -1.15810424246281 0.110684961995552 no 2960 0.123410749461158 4245 2913 A selective serotonin reuptake inhibitor. SGTC_1290 0986-0249 10.2 µM -1.15831825770333 0.11064122819678 no 2961 0.123367091657362 4099 53329 SGTC_2659 sanguinarine 24.21 µM -1.15857721498189 0.110588327098332 no 2962 0.123314280420402 4194 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1874 staurosporine 7.6 µM -1.1588890361962 0.110524650750645 no 2963 0.123250709239796 4256 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_428 3448-4153 16.5 µM -1.15929613224644 0.110441558092697 no 2964 0.123167748887287 4223 3834874 SGTC_231 b-estradiol 524 µM -1.15978555316594 0.110341721349382 no 2965 0.123068063720986 4221 450 A steroid. SGTC_3095 9117207 49.47 µM -1.1603298472366 0.110230767083905 no 2966 0.122957268437119 4223 17015229 SGTC_2171 5739187 198.077 µM -1.16137239847965 0.110018466642126 no 2967 0.12274524434203 4190 2262761 SGTC_2508 celastrol 40.54 µM -1.16187701587207 0.109915814057266 no 2968 0.122642712234505 4187 122724 Celastrol is a natural product and antioxidant. SGTC_2667 digitoxin 100 µM -1.16210537278554 0.109869382790771 no 2969 0.122596332643444 4181 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_495 decylubiquinone 155 µM -1.16330552963606 0.109625589151102 no 2970 0.122352781479145 4285 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2348 9022543 33.42 µM -1.16400301106254 0.109484084969602 no 2971 0.122211395763401 4285 3162678 YDL140C RPO21 SGTC_262 fenpropimorph 62.5 µM -1.16773806756227 0.108728553118338 no 2972 0.121456218246783 4247 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_481 bay k-8644 50 µM -1.16792004517895 0.108691838486951 no 2973 0.121419508848397 4230 2303 A calcium channel antagonist. SGTC_943 3253-1379 105 µM -1.16934480342534 0.108404696582629 no 2974 0.121132369379287 4274 668464 SGTC_232 clozapine 119 µM -1.17251902518593 0.107766936104616 no 2975 0.120494369167613 4235 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_84 0443-0269 128.823 µM -1.1729838647406 0.107673768500643 no 2976 0.120401138119855 4183 6150058 SGTC_3312 9133330 71.43 µM -1.17833514085062 0.106605391588903 no 2977 0.119331511806906 4303 17617324 SGTC_870 0573-2213 57.6 µM -1.18086530894954 0.106102918931778 no 2978 0.118828117261219 4256 3916321 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.18222375403619 0.105833848792249 no 2979 0.118558464850128 4298 4174840 SGTC_962 1254-0300 21.5 µM -1.18223439284908 0.105831743487901 no 2980 0.118556354745394 4226 7340576 SGTC_2053 5265679 138 µM -1.18396245346315 0.105490180927809 no 2981 0.118213962976879 4181 764595 SGTC_3282 9108498 15.4605 µM -1.18474830871816 0.105335115463935 no 2982 0.118058487927539 4241 16459645 SGTC_1021 4476-0760 85.3 µM -1.18528180509888 0.105229939628939 no 2983 0.117953022477054 4272 746768 SGTC_561 1550-0330 72.9 µM -1.18873617142638 0.104550769096937 no 2984 0.117271751039784 4218 6812934 SGTC_3050 9093513 49.47 µM -1.18950996153951 0.104399068834733 no 2985 0.117119526706656 4236 25236664 SGTC_1166 k206-0078 225 µM -1.19020007360495 0.104263908130114 no 2986 0.116983882138977 4292 5404595 SGTC_1280 0880-0253 10.1 µM -1.19034923959778 0.104234710159867 no 2987 0.116954577544266 4257 6836607 SGTC_2434 5670830 169.91 µM -1.19504884524584 0.103317835215882 no 2988 0.116033973308702 4304 1549830 SGTC_2657 nystatin 74.44 µM -1.19814227637608 0.102717522854159 no 2989 0.115430816432218 4319 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1488 4013-0813 75.9 µM -1.2000323128369 0.10235199151623 no 2990 0.115063395641037 4222 2910057 SGTC_294 k038-0071 157 µM -1.20354223452324 0.101675687135508 no 2991 0.114383278959535 4298 24152826 SGTC_1633 st005664 67.9 µM -1.20469288137061 0.101454686080382 no 2992 0.114160942574235 4272 2063822 SGTC_999 SEC7.066 22.7 µM -1.20990325294277 0.10045832550126 no 2993 0.113158009435824 4248 740511 YDR170C SEC7 SGTC_1318 1280-3875 124 µM -1.21422912624752 0.0996365441587442 no 2994 0.112330120568027 4294 373245 SGTC_1429 4049-0205 9.46 µM -1.21465629668109 0.0995556623225865 no 2995 0.112248603779264 4326 22774478 SGTC_2571 chrysanthemic acid 100 µM -1.21522327292594 0.0994483833230167 no 2996 0.11214047320266 4279 2743 An insecticide. SGTC_1076 itraconazole 331 nM -1.21560705080062 0.0993758157177731 no 2997 0.112067323475634 4297 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_445 e6 berbamine 66 µM -1.21910687054559 0.09871582896125 no 2998 0.111401816265036 4318 6610268 A calcium/calmodulin antagonist. SGTC_3303 9125618 40.5795 µM -1.21981650489917 0.0985824000622282 no 2999 0.111267221581858 4308 22695467 SGTC_2163 5671233 125 µM -1.2214988961151 0.0982665963155061 no 3000 0.110948591657725 4283 701023 SGTC_1730 st033808 45.1 µM -1.22310766346827 0.097965306261261 no 3001 0.11064451725667 4238 1045166 SGTC_3327 9140648 26.9345 µM -1.22900260771318 0.0968670858794949 no 3002 0.109535414153471 4335 8029710 SGTC_1238 0333-0287 48.8 µM -1.23034477146338 0.0966183107763547 no 3003 0.109284012683468 4282 7226 SGTC_2961 9083290 32.55 µM -1.23036563408829 0.0966144475179917 no 3004 0.109280108167668 4251 17741490 SGTC_2860 9025725 38.96 µM -1.23098055563582 0.0965006297340244 no 3005 0.109165068381366 4348 40546248 SGTC_1847 st056231 15 µM -1.23169086049036 0.0963692798063816 no 3006 0.109032292591508 4308 5393180 SGTC_3072 9116419 49.47 µM -1.23173292634656 0.0963615050901692 no 3007 0.109024432951791 4349 17170162 SGTC_3274 9138298 49.47 µM -1.23590042713317 0.0955935403980783 no 3008 0.108247789123177 4293 17015756 SGTC_1575 cyproterone acetate 48 µM -1.23664930599558 0.0954560197189265 no 3009 0.108108653252261 4333 9880 An androgen receptor antagonist and liver toxin. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.23910114525322 0.0950067940799506 no 3010 0.107654021478747 4410 688664 SGTC_754 3474-0146 171 µM -1.23935199315151 0.0949609217254313 no 3011 0.107607585851377 4309 24762078 SGTC_2861 9024595 19.48 µM -1.23962650766301 0.094910740176916 no 3012 0.107556785727542 4225 16482810 SGTC_2400 5203494 178.7 µM -1.245394225788 0.0938609083536515 no 3013 0.106493437383247 4236 6777674 SGTC_1105 epirubicin 18.1 µM -1.24578348472286 0.0937903659808443 no 3014 0.106421947179011 4346 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.24581679445041 0.0937843313359673 no 3015 0.1064158312178 4277 2333 A French combination drug. SGTC_795 0685-0265 78 µM -1.24710096813105 0.0935518990952722 no 3016 0.106180239010828 4329 302754 SGTC_405 ebelactone b 50 µM -1.24909794042985 0.093191297647911 no 3017 0.105814626924653 4260 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1380 2291-0730 164 µM -1.24966427175769 0.0930892200763709 no 3018 0.105711106990782 4335 2999191 SGTC_3236 9132701 49.47 µM -1.25112785268471 0.0928258018288195 no 3019 0.105443917592872 4323 24282524 SGTC_1945 st075991 56.6 µM -1.25116194779429 0.0928196718985454 no 3020 0.105437699062241 4304 1084980 SGTC_2252 omeprazole 400 µM -1.25218745718603 0.0926354363240452 no 3021 0.105250782664333 4330 4594 A proton pump inhibitor. SGTC_594 1487-1584 10.8 µM -1.25559722239878 0.0920248075403366 no 3022 0.104631019470619 4277 5013332 SGTC_379 3970-0972 5.9 µM -1.25724226361167 0.0917312777201375 no 3023 0.104332961809033 4308 2898042 YBL034C STU1 SGTC_460 trequinsin 123 µM -1.2603449894258 0.0911795375611122 no 3024 0.10377246850098 4419 5537 A vasodilator. SGTC_2199 6590217 200 µM -1.26228133682577 0.0908364572425277 no 3025 0.103423784941251 4236 703109 SGTC_3244 9134489 49.47 µM -1.26623432414101 0.0901390457086057 no 3026 0.102714601106856 4354 16584271 SGTC_2825 7998094 58.44 µM -1.26784319418096 0.0898563402489477 no 3027 0.102426976754542 4327 2987815 SGTC_612 0302-0167 22.4 µM -1.26799217674411 0.0898301948884211 no 3028 0.102400372181707 4348 235821 SGTC_2113 5491891 107.031 µM -1.27127581131602 0.0892553756971177 no 3029 0.101815272229326 4334 789979 SGTC_512 prima-1 270 µM -1.27401013878498 0.0887788078670964 no 3030 0.101329911505251 4350 322968 A re-activator of the apoptotic function of mutant p53. SGTC_825 1988-2224 89.6 µM -1.27620633168809 0.0883974060646849 no 3031 0.100941295497877 4327 1180859 SGTC_2024 5144227 134 µM -1.27751848912884 0.0881701136771919 no 3032 0.100709628573957 4337 3475211 SGTC_1307 1187-1599 12.2 µM -1.28137791636375 0.0875041076701863 no 3033 0.100030478532654 4350 1538471 SGTC_1505 k297-0037 20.6 µM -1.28242494021948 0.0873240760167898 no 3034 0.0998468099677416 4340 4089396 SGTC_2588 indole-3-carbinol 100 µM -1.28420594787387 0.0870184741727452 no 3035 0.09953495230676 4367 3712 Induces cell cycle arrest. SGTC_36 0335-0881 14.2 µM -1.28421780282622 0.0870164426696499 no 3036 0.0995328788708382 4253 23828853 SGTC_3138 9097216 49.47 µM -1.28873088194428 0.0862456379146324 no 3037 0.09874583118642 4294 25237486 SGTC_2128 5255449 168.493 µM -1.28956281349371 0.0861041085552666 no 3038 0.0986012470129234 4296 736008 SGTC_995 3931-2021 34.6 µM -1.29163165020821 0.0857529085441824 no 3039 0.0982423689286483 4358 730143 SGTC_3047 9092122 49.47 µM -1.29188091596686 0.0857106663639877 no 3040 0.0981991938281283 4320 17173831 SGTC_1960 st011366 51.8 µM -1.29210515096687 0.0856726793690831 no 3041 0.0981603661604105 4383 3972846 SGTC_454 lyso-paf C-16 6.67 µM -1.29348769686248 0.0854387447124172 no 3042 0.0979212182688222 4374 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_355 1311-2252 105 µM -1.2964964115875 0.0849313070068323 no 3043 0.0974022577665274 4340 5338538 SGTC_2859 9028643 45.46 µM -1.29669566431732 0.0848977817792695 no 3044 0.0973679608709133 4193 17151580 SGTC_2017 5132927 60.65 µM -1.29819646325063 0.0846455838829516 no 3045 0.0971099165764338 4345 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_263 alizarin 107.927 µM -1.29846117568817 0.0846011593168999 no 3046 0.0970644545814188 4401 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_3217 9129673 49.47 µM -1.29880059199784 0.0845442233894611 no 3047 0.09700618572299 4358 17248312 SGTC_1137 ixabepilone 100 µM -1.29954094673991 0.0844201311445311 no 3048 0.0968791753714886 4315 154225 A novel microtubule stabilizer. SGTC_2705 st078069 42.8 µM -1.30018614815496 0.0843120992140966 no 3049 0.0967685884980305 4395 1530061 SGTC_2812 7970281 58.44 µM -1.30179637905831 0.0840429362391964 no 3050 0.0964930009729444 4401 2233435 SGTC_420 mitomycin C 81.9 mM -1.30193854072603 0.0840192038084875 no 3051 0.0964686980424184 4349 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_755 1995-0008 37.3 µM -1.30329282796004 0.0837933716986335 no 3052 0.0962374043548296 4331 689533 SGTC_2815 7968870 71.43 µM -1.3043708332349 0.0836139367119796 no 3053 0.0960535874050831 4311 2977326 YHR190W ERG9 SGTC_3232 9132874 49.47 µM -1.30627576334347 0.0832975653879844 no 3054 0.0957293980691866 4330 3784940 SGTC_1661 st013063 9.66 µM -1.31346297619042 0.0821120113829298 no 3055 0.0945134943793036 4442 721395 SGTC_3076 9116187 49.47 µM -1.3142461493921 0.0819835963677661 no 3056 0.0943816913700927 4357 27241210 SGTC_13 0199-0087 65 µM -1.31515838909056 0.08183420948331 no 3057 0.0942283382484815 4467 4589825 SGTC_2008 4012253 172 µM -1.31659825522421 0.081598836954209 no 3058 0.093986661985053 4367 603940 SGTC_918 glabranin 770.725 nM -1.31761994599705 0.0814321327089008 no 3059 0.0938154525691438 4383 124049 Also referred to as licorice root. SGTC_286 k060-0067 22.9 µM -1.3202396127095 0.0810058684060551 no 3060 0.0933775150821125 4412 5985051 SGTC_2184 6075246 200 µM -1.32091511356714 0.080896226540985 no 3061 0.0932648348929279 4365 2267320 SGTC_3140 9094243 49.47 µM -1.32251252024021 0.0806373940956884 no 3062 0.0929987714990483 4342 19291112 SGTC_2066 5222451 176 µM -1.32517538462738 0.0802073135298061 no 3063 0.0925564938086489 4332 2281147 SGTC_202 3594-0513 34.79 µM -1.3260165069813 0.0800718243795697 no 3064 0.0924171148814587 4451 708429 SGTC_2173 5763948 167 µM -1.32792038076292 0.0797657849256363 no 3065 0.092102205513022 4364 2867177 SGTC_1174 0739-0097 51.1 µM -1.33091560256292 0.0792861080693621 no 3066 0.091608391368898 4424 728447 SGTC_1001 4048-4355 44.4 µM -1.33148203368315 0.0791956416639753 no 3067 0.0915152263967976 4378 21824233 SGTC_601 0986-0029 62.9 µM -1.33256990589895 0.0790221135708086 no 3068 0.0913364932515731 4342 24747981 SGTC_2072 5231554 129 µM -1.33265072628601 0.0790092332931541 no 3069 0.0913232251126896 4444 789545 SGTC_1909 st060837 51.5 µM -1.33570215571442 0.0785240920587837 no 3070 0.0908233222492519 4344 678937 SGTC_2071 5230951 39.92 µM -1.33718377744694 0.0782893476500195 no 3071 0.0905813279499448 4433 1799272 SGTC_2999 9069765 71.4286 µM -1.3383919222954 0.0780983264399922 no 3072 0.090384355350853 4342 2097066 SGTC_3220 9131269 49.47 µM -1.33868349315652 0.0780522788314356 no 3073 0.0903368661212721 4400 17722206 SGTC_2067 5224629 34.075 µM -1.34252680726556 0.0774472302640743 no 3074 0.0897126221973767 4388 2835000 SGTC_3153 9100258 49.47 µM -1.34355785309872 0.0772855214407412 no 3075 0.0895457031263795 4314 25236848 SGTC_2782 7736369 71.43 µM -1.3454300934708 0.0769925359556053 no 3076 0.0892431912264399 4395 2950836 YOL077C BRX1 SGTC_1933 st074711 15.9 µM -1.34782837967784 0.0766184642157939 no 3077 0.0888567938965083 4386 17250958 SGTC_867 0518-0118 155 µM -1.34816487207077 0.0765660907122855 no 3078 0.0888026800789308 4391 6848158 SGTC_3301 9125354 19.7965 µM -1.34841423667322 0.0765272958219119 no 3079 0.0887625937560819 4370 41905162 SGTC_144 4161-2749 112.381 µM -1.34866796576425 0.076487837275516 no 3080 0.0887218196573337 4379 797501 YMR168C CEP3 SGTC_613 3914-0030 117 µM -1.35050554686921 0.0762025286239417 no 3081 0.0884269378140641 4118 1145395 SGTC_3166 9102297 49.47 µM -1.35052422082961 0.0761996334090441 no 3082 0.0884239449036323 4394 25237072 SGTC_1749 st037932 54.2 µM -1.35140896584417 0.076062558277664 no 3083 0.0882822316592764 4421 594497 SGTC_451 chloral hydrate 100 µM -1.35142796165649 0.0760596172822638 no 3084 0.0882791908792039 4407 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_347 4534-1311 26.2 µM -1.35320930085106 0.0757842088984744 no 3085 0.0879943873836834 4406 2862016 SGTC_2030 5175110 200 µM -1.35441499913451 0.0755982303912058 no 3086 0.0878020074929151 4409 2831986 SGTC_826 1683-5028 118 µM -1.35482190865406 0.0755355432951288 no 3087 0.0877371523154718 4441 722377 SGTC_2140 5586273 200 µM -1.3579699723439 0.0750519011943047 no 3088 0.0872366062261613 4379 854421 SGTC_3202 9113761 49.47 µM -1.36035062804963 0.074687728190214 no 3089 0.0868594971239371 4335 4798415 SGTC_1752 st044819 83.042 µM -1.36315305269298 0.0742607662621761 no 3090 0.0864171398027319 4360 441209 YML126C ERG13 SGTC_2433 5607874 27.82 µM -1.36598679270925 0.0738309312016449 no 3091 0.085971554414472 4382 2252428 SGTC_422 cantharidin 155 µM -1.3680624966269 0.0735172870512618 no 3092 0.0856462572731074 4322 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1522 st012842 45.6 µM -1.36828730348627 0.0734833794032044 no 3093 0.0856110817026403 4257 3491067 YOR116C RPO31 SGTC_2137 5261020 140 µM -1.36907002718492 0.0733654143910621 no 3094 0.0854886931791878 4391 763655 SGTC_184 1494-0393 24.714 µM -1.37285529066756 0.0727969769378591 no 3095 0.0848986690331354 4391 3090647 SGTC_2098 5376439 882.5 nM -1.37374828275268 0.0726633681562378 no 3096 0.0847599208975753 4457 2844116 SGTC_694 1315-0438 43.2 µM -1.3741987660931 0.0725960384918748 no 3097 0.0846899918621938 4429 6793154 SGTC_583 1488-1091 88.9 µM -1.37813363795454 0.0720099588388461 no 3098 0.084081015817073 4515 4303273 SGTC_2146 5545642 200 µM -1.38143216833499 0.0715214599582907 no 3099 0.0835730603626302 4380 825326 SGTC_2416 tofa 880 nM -1.38248911538122 0.071365469563783 no 3100 0.0834107851418004 4373 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2814 7977482 42.97 µM -1.38262623239385 0.0713452521881177 no 3101 0.0833897506559371 4426 6456762 SGTC_2032 5185112 25.99 µM -1.38554706775959 0.0709156297773969 no 3102 0.082942625385085 4294 5718189 SGTC_610 4215-0184 155 µM -1.38870982426572 0.0704526674513458 no 3103 0.0824605027904147 4439 5605015 SGTC_830 4076-0286 57.8 µM -1.38904322864519 0.0704039996213661 no 3104 0.0824098026553666 4480 6866659 SGTC_2192 5915882 198.485 µM -1.39635210372239 0.0693435880614788 no 3105 0.0813042453714284 4396 2876149 SGTC_3319 9138450 16.7555 µM -1.39688995867778 0.0692660417599845 no 3106 0.0812233323110141 4360 2029690 SGTC_486 niguldipine 82 µM -1.39714597141097 0.0692291540939347 no 3107 0.0811848399789475 4503 1236 A calcium channel blocker. SGTC_3155 9099265 49.47 µM -1.39917288567039 0.0689376396390139 no 3108 0.0808805726815753 4406 25236499 SGTC_1440 4100-1550 40 µM -1.39926751537903 0.068924052978526 no 3109 0.0808663885427819 4446 742806 SGTC_2836 9010338 19.48 µM -1.40930609000217 0.0674944337052805 no 3110 0.0793723394136983 4409 2994051 SGTC_3040 9091894 49.47 µM -1.41064137346372 0.0673060120226855 no 3111 0.0791751928447037 4307 25236966 SGTC_1931 st074438 57.1 µM -1.41276917872989 0.0670065982872466 no 3112 0.0788618016928264 4448 2787313 SGTC_3193 9111931 49.47 µM -1.41408378240429 0.0668221295697137 no 3113 0.0786686521269418 4440 17087244 SGTC_313 3474-0040 5.03 µM -1.41510419156392 0.0666792140701345 no 3114 0.0785189747138408 4459 1043375 YIL048W NEO1 SGTC_2473 5854593 8.94 µM -1.41550498909508 0.0666231442956956 no 3115 0.078460243324727 4362 2872951 SGTC_578 3460-0051 92 µM -1.42131196073775 0.0658148636234957 no 3116 0.0776130439385754 4508 2876744 SGTC_654 1124-0271 80.9 µM -1.42346348717968 0.0655173267415661 no 3117 0.0773009197691034 4434 5403748 SGTC_2710 st078562 53.7235 µM -1.43035818347574 0.0645708760929913 no 3118 0.0763071217407402 4411 17250908 SGTC_1195 1502-0147 41.1 µM -1.43228635841291 0.0643081005757041 no 3119 0.0760309427662939 4453 817940 SGTC_1410 3909-8106 77.9 µM -1.44084662115667 0.0631515141053568 no 3120 0.0748140095231819 4524 1039210 SGTC_354 2783-3500 4.88 µM -1.44234015453086 0.0629513912014626 no 3121 0.0746032188011071 4444 6740761 SGTC_522 1273-0010 11.6 µM -1.44397405752233 0.0627330259924902 no 3122 0.0743731364539863 4485 5705015 SGTC_183 3914-0051 30.55 µM -1.44811190721565 0.0621826577307241 no 3123 0.0737928779934712 4455 1596232 SGTC_731 3966-0296 387 µM -1.45214996446752 0.0616492012415699 no 3124 0.0732299558512869 4462 660956 SGTC_2315 7733312 200 µM -1.45469693013679 0.0613145707835141 no 3125 0.0728765914209696 4366 726316 SGTC_316 k060-0003 58.6 µM -1.45512549359122 0.0612584041576259 no 3126 0.0728172613088389 4499 6152314 SGTC_3272 9137413 49.47 µM -1.45529518948049 0.061236175284811 no 3127 0.0727937789172182 4396 17614870 SGTC_858 0438-0351 2.77 µM -1.45654081798858 0.0610732002911426 no 3128 0.07262158721057 4452 2799119 SGTC_652 0437-0092 114 µM -1.45750488227478 0.0609472973621356 no 3129 0.0724885323276422 4429 3091274 SGTC_2241 6772625 37.8075 µM -1.45839603976488 0.0608310963295615 no 3130 0.0723657058143045 4274 2285411 SGTC_2445 5742597 35.57 µM -1.46586182832691 0.0598644002356802 no 3131 0.0713429664697285 4489 1774255 SGTC_1493 4348-0038 111 µM -1.46675732496484 0.0597492610257358 no 3132 0.0712210412278987 4454 800424 SGTC_2601 securinine 100 µM -1.46719760557341 0.0596927152448333 no 3133 0.0711611540571306 4436 442872 A GABA receptor antagonist. SGTC_423 5-fluorouracil 457 µM -1.46932910013586 0.0594195574296719 no 3134 0.0708717737588449 4417 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_381 3461-2219 42.7 µM -1.47072137149336 0.0592416631436164 no 3135 0.0706832420468321 4446 2883159 SGTC_861 0443-0273 110 µM -1.47167130637735 0.0591205272666578 no 3136 0.0705548298194188 4470 6149169 SGTC_2671 danthron 100 µM -1.47204548601737 0.0590728651765094 no 3137 0.0705042974602152 4478 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1223 0764-0573 147 µM -1.4763464890173 0.0585271758005783 no 3138 0.0699254499956115 4470 1609797 SGTC_1662 st014054 52 µM -1.47834622393579 0.0582748112528909 no 3139 0.069657565622087 4561 2838777 SGTC_1524 corynanthine 62.1 µM -1.47896009878285 0.058197512577342 no 3140 0.0695754896772791 4554 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1737 st035557 69.7 µM -1.47902361002573 0.0581895198880105 no 3141 0.0695670023855177 4320 5716916 SGTC_1327 1436-0082 2.18 µM -1.47957128387177 0.0581206326422006 no 3142 0.0694938473508543 4502 15992205 SGTC_1444 4112-3581 28 µM -1.48033483458859 0.0580246990400584 no 3143 0.0693919556476306 4560 2877249 SGTC_148 3253-0744 288.01 µM -1.48120273712788 0.0579158056894239 no 3144 0.0692762785310733 4365 6893655 SGTC_2096 5468907 200 µM -1.48717343396766 0.0571710266111533 no 3145 0.0684845052892842 4480 759785 SGTC_2955 9076254 12.21 µM -1.49411255480844 0.0563149417866627 no 3146 0.0675731015189859 4410 16459619 SGTC_923 1900-2434 73.3 µM -1.49848785577645 0.0557803731949388 no 3147 0.0670032727605304 4474 5910570 SGTC_3027 9089541 49.47 µM -1.49976277608487 0.0556253607634824 no 3148 0.0668379314068099 4487 9943819 SGTC_1331 1472-0049 76.2 µM -1.50026103211729 0.0555648723005475 no 3149 0.0667733996349349 4466 24051409 SGTC_723 4182-0001 115 µM -1.50377636699428 0.0551395835849099 no 3150 0.0663194791237689 4508 744821 YLR208W SEC13 SGTC_1674 st016616 23.6 µM -1.50855790983299 0.0545652402181088 no 3151 0.0657058986090748 4457 625830 SGTC_554 4483-2211 187 µM -1.50959572909203 0.0544412077900721 no 3152 0.0655733059088783 4548 747107 SGTC_3235 9132602 49.47 µM -1.51219415493139 0.0541316413682864 no 3153 0.0652422387806809 4485 4912240 SGTC_960 1222-0186 7.7 µM -1.51582455183742 0.0537014647184052 no 3154 0.0647818610633638 4486 3126296 SGTC_3043 9092303 49.47 µM -1.51823978817008 0.0534167791022717 no 3155 0.0644769802567298 4515 25236084 SGTC_1273 0849-0096 14.1 µM -1.51871289173951 0.0533611543801388 no 3156 0.0644173900878455 4529 5286025 SGTC_2881 9058953 51.95 µM -1.52514405916963 0.0526095604031836 no 3157 0.0636115849461509 4471 17122249 SGTC_1465 k213-0056 144 µM -1.52676451291679 0.0524215134689595 no 3158 0.0634097894376571 4423 24048857 YMR208W ERG12 SGTC_2883 9059145 45.46 µM -1.52731180053385 0.0523581236919073 no 3159 0.0633417482522389 4498 16476510 SGTC_3248 9135562 49.47 µM -1.52850753887393 0.052219838636122 no 3160 0.0631932865988899 4506 17650701 SGTC_530 4358-1714 28 µM -1.52882829291936 0.0521827933717685 no 3161 0.0631535082291846 4496 1564641 SGTC_269 exalamide 29 µM -1.53039038544358 0.0520026788460263 no 3162 0.0629600636999304 4474 3316 A derivative of salicylamide. SGTC_1213 1315-0166 115 µM -1.53278158945285 0.0517279221065154 no 3163 0.0626648391489391 4510 768401 SGTC_1478 0453-0656 35.7 µM -1.53303949150835 0.0516983574311415 no 3164 0.0626330624275157 4541 5258496 SGTC_3129 9127257 49.47 µM -1.54082851336542 0.050811772880366 no 3165 0.0616792639465075 4444 837894 SGTC_3117 9124945 49.47 µM -1.5428043710399 0.0505888070149686 no 3166 0.0614391243110098 4432 17592065 SGTC_793 0488-0545 106 µM -1.55163773576026 0.0496015196357064 no 3167 0.0603744643081093 4537 292548 SGTC_3069 9117009 49.47 µM -1.55174554232556 0.049589565974899 no 3168 0.0603615604472845 4511 41904981 SGTC_1466 k213-0079 57.5 µM -1.55446812913824 0.0492884452338017 no 3169 0.0600363965928544 4513 3657981 SGTC_414 piperonyl butoxide 100 µM -1.55498601639066 0.0492313320142694 no 3170 0.0599746998643809 4521 5794 A potent inhibitor of cytochrome P450. SGTC_2087 5276107 200 µM -1.5563711231714 0.0490788404624405 no 3171 0.0598099338804904 4510 144405 SGTC_957 1187-1561 14.1 µM -1.55713185902696 0.0489952488775462 no 3172 0.0597195911915503 4464 1538454 SGTC_125 0133-0007 11.75 µM -1.55769895132148 0.0489330093675129 no 3173 0.0596523146116077 4605 26541 SGTC_3245 9134821 49.47 µM -1.56000431955931 0.048680640742967 no 3174 0.0593794302090687 4527 17014901 SGTC_1986 st071812 45 µM -1.56307163910604 0.0483464756060462 no 3175 0.0590178727599813 4470 11838594 SGTC_750 4073-0104 132 µM -1.56314582447078 0.0483384163596247 no 3176 0.0590091496667502 4213 22330957 SGTC_1019 4262-0212 3.4 µM -1.57517540928624 0.0470457137352384 no 3177 0.057607980818672 4535 4677213 SGTC_2661 dactinomycin 12.96 µM -1.57563026592565 0.0469973839328345 no 3178 0.0575555184187898 4528 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2753 fluvastatin 17.09 µM -1.57707203493286 0.046844454954107 no 3179 0.0573894755108514 4516 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2582 agaric acid 100 µM -1.58105990109459 0.0464235386449308 no 3180 0.0569321710611478 4145 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2972 9093619 59.92 µM -1.5831094655679 0.0462083927986563 no 3181 0.0566982582708716 4500 25236256 SGTC_547 1120-0019 610 nM -1.58480852548448 0.0460306475997829 no 3182 0.0565049223912231 4522 3676939 SGTC_3326 9140064 16.379 µM -1.58587723858768 0.0459191270835809 no 3183 0.0563835800267909 4494 1868434 SGTC_2531 methyl deoxycholate 70.07 µM -1.59149269494333 0.045336715120418 no 3184 0.0557493690655724 4475 16667744 Haematoxylin. SGTC_3187 9109394 49.47 µM -1.59216119183519 0.0452677789315027 no 3185 0.0556742453170875 4551 17098090 SGTC_3094 9117742 49.47 µM -1.59406272140399 0.0450721519449078 no 3186 0.0554609937099281 4500 17149698 SGTC_62 0180-0423 3.232 µM -1.60261483341909 0.0442007171913728 no 3187 0.0545098584024001 4498 30102 YGL099W LSG1 SGTC_449 xestospongin c 11.1929 µM -1.60659948080876 0.0437993577724447 no 3188 0.0540711282455642 4568 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1126 isoteolin 1.0172 µM -1.61570088230617 0.0428936296145293 no 3189 0.0530795000717542 4495 133323 SGTC_2696 st077691 74.316 µM -1.61666707267253 0.0427983741428824 no 3190 0.0529750825925904 4556 757133 SGTC_246 cycloheximide 667 µM -1.61775250989293 0.0426915662858708 no 3191 0.0528579723255268 4490 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1845 st056753 3.01 µM -1.61831210065495 0.0426365863659723 no 3192 0.0527976770981924 4517 5375839 SGTC_2920 7982904 15.77 µM -1.62365675233461 0.0421143526149427 no 3193 0.0522245429514286 4528 6456808 SGTC_1108 betulinic acid 729.144 nM -1.62573677092951 0.0419125155278515 no 3194 0.0520028320934871 4544 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_3090 9117696 49.47 µM -1.62782964754346 0.0417102219198115 no 3195 0.0517805061028032 4521 7923821 SGTC_64 000l-0018 272.079 µM -1.62902974978596 0.0415945794554981 no 3196 0.0516533606208034 4478 6811119 SGTC_472 calcifediol 10 µM -1.62948604302085 0.041550679017043 no 3197 0.0516050835609543 4594 5283731 A vitamin D metabolite. SGTC_2369 9071472 200 µM -1.62999228063741 0.0415020173145732 no 3198 0.051551564237557 4573 17296037 SGTC_1886 st057356 49.9 µM -1.64493972283088 0.0400858958674771 no 3199 0.0499911210750646 4548 24207747 SGTC_42 0133-0086 60.653 µM -1.64571451405935 0.0400135757638659 no 3200 0.049911274701615 4459 162923 Model of phenazepam hydroxylation. SGTC_890 0929-0006 47.2 µM -1.64755753357393 0.0398419717452866 no 3201 0.0497217504188322 4575 1378169 SGTC_2792 7535235 81.82 µM -1.64758356878956 0.0398395518916274 no 3202 0.0497190772431087 4531 1281891 SGTC_3270 9137563 49.47 µM -1.65527009548504 0.0391303320281745 no 3203 0.0489348610622634 4573 17015724 SGTC_3002 9075603 71.4286 µM -1.66747302030598 0.0380255318652594 no 3204 0.0477101924050097 4522 20105405 SGTC_1337 1486-1011 40.3 µM -1.66913175619341 0.0378773410028051 no 3205 0.047545635519407 4577 X1337 SGTC_250 brefeldin a 552.239 µM -1.67221900370138 0.0376027823612282 no 3206 0.047240572229085 4527 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1792 st045773 43.6 µM -1.67512902633169 0.0373454746404497 no 3207 0.0469544595016787 4564 2919270 SGTC_2664 lyso-paf C-16 73.48 µM -1.68449645348038 0.036526946541095 no 3208 0.0460428821426584 4574 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_247 mechlorethamine 29.705 µM -1.6858320669119 0.0364114450595842 no 3209 0.0459140747412748 4557 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3127 9126946 49.47 µM -1.68931190937919 0.0361119177958726 no 3210 0.0455798361459189 4539 27243249 SGTC_1167 k781-0610 148 µM -1.69720555516125 0.0354399486269842 no 3211 0.0448289026224568 4611 4525169 SGTC_633 0437-0093 97.7 µM -1.70176394607654 0.0350565954157 no 3212 0.0443998138340035 4524 2831118 SGTC_1610 st001799 48.1 µM -1.70409632714971 0.0348617659032368 no 3213 0.0441815463466305 4560 621897 SGTC_990 3985-0011 41.3 µM -1.70464672304131 0.0348159198506406 no 3214 0.0441301658752896 4557 5399565 YGL099W LSG1 SGTC_546 peri-Naphthalide 147 µM -1.70829852005512 0.034512990209197 no 3215 0.043790482891121 4554 223824 A penicillin ester. SGTC_404 fumagillin 50 µM -1.70936920706355 0.0344245845153249 no 3216 0.0436912905547222 4597 12015870 A methionine aminopeptidase binder. SGTC_900 1112-0045 141 µM -1.71708132162963 0.0337932847664363 no 3217 0.04298215723286 4511 56211 YIL048W NEO1 SGTC_1746 st038117 42 µM -1.72187685853115 0.0334055557931565 no 3218 0.0425459139293833 4613 2898218 SGTC_1154 4088-0362 150 µM -1.72582004311398 0.0330894921363957 no 3219 0.042189896407282 4615 6618304 SGTC_2662 daunorubicin 22.37 µM -1.73479907125289 0.0323789701116589 no 3220 0.0413882003832525 4486 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_380 3970-0968 6 µM -1.73502316961036 0.0323613992120779 no 3221 0.0413683506965374 4509 2891601 SGTC_2706 st078239 82.5 µM -1.73636001133416 0.0322567447388591 no 3222 0.0412500991440031 4580 15434492 SGTC_1335 1486-0900 202 µM -1.73663618436143 0.0322351594215088 no 3223 0.0412257041918725 4606 X1335 SGTC_520 3584-0023 682 µM -1.73996241183893 0.0319761211359621 no 3224 0.0409328091795712 4582 1340790 SGTC_1364 1653-0028 37.6 µM -1.74114292557567 0.0318845999910046 no 3225 0.0408292643369201 4614 5718652 SGTC_289 k017-0060 526 µM -1.74156295185782 0.0318520890376628 no 3226 0.0407924744226447 4597 5512909 SGTC_1402 3909-7673 35.9 µM -1.75485909918819 0.0308370073500468 no 3227 0.0396417058569574 4630 5328014 SGTC_2277 7947813 106.88 µM -1.75573509669405 0.0307710812473631 no 3228 0.0395668255578954 4612 1246798 SGTC_2552 juarezic acid 87.02 µM -1.76459160677533 0.0301110858863576 no 3229 0.0388162135519665 4574 1549512 SGTC_3001 9076041 71.4286 µM -1.77435580845452 0.029397094563704 no 3230 0.0380021573417324 4610 16004211 SGTC_16 erodoxin 22.806 µM -1.77588394577415 0.0292866344983935 no 3231 0.0378760237973682 4670 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3317 9138495 8.753 µM -1.78066942541455 0.0289429481328274 no 3232 0.0374832353826468 4543 17020139 SGTC_2351 9026858 72.31 µM -1.79037900901498 0.0282559155656798 no 3233 0.0366965012452151 4526 1409300 SGTC_1893 st059353 36.1 µM -1.81127987781442 0.026822994985029 no 3234 0.0350487694421559 4627 3112488 SGTC_1202 1988-0068 29.6 µM -1.8205695049229 0.0262058750738422 no 3235 0.0343361609446083 4612 2850480 SGTC_3031 9088762 49.47 µM -1.82795092391178 0.0257240238402614 no 3236 0.0337784586706596 4619 205253 SGTC_390 dec-rvkr-cmk 16.7 µM -1.82907551760155 0.025651266610751 no 3237 0.0336941480051252 4666 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2697 mebhydrolin 72.4 µM -1.83637859444486 0.0251829638008616 no 3238 0.0331508415679988 4638 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1681 tripelennamine 100 µM -1.83879857202063 0.0250293742244907 no 3239 0.0329724091892285 4571 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_3240 9133527 49.47 µM -1.83930556727617 0.024997296268585 no 3240 0.0329351273292566 4631 17617455 SGTC_789 1309-1135 70.6 µM -1.83980362209109 0.0249658175488024 no 3241 0.0328985367401504 4619 3092424 SGTC_1025 k007-0731 70 µM -1.85320699490144 0.0241310808322292 no 3242 0.0319263477375483 4620 6256118 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.85468097717216 0.024040731725542 no 3243 0.0318208984046779 4596 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2837 9008476 45.46 µM -1.85655093750646 0.0239265199503627 no 3244 0.0316875348316763 4611 2992805 SGTC_1557 sumaresinolic acid 42.3 µM -1.86304233790512 0.0235335771186017 no 3245 0.0312281549110633 4625 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_3234 9132280 49.47 µM -1.86972098886421 0.0231349793739022 no 3246 0.0307612866510615 4662 17612295 SGTC_2951 9072950 58.06 µM -1.87256017666542 0.022967259999038 no 3247 0.0305645724200869 4591 16488155 SGTC_556 4058-0063 51.5 µM -1.87368341918693 0.0229011900050781 no 3248 0.0304870363030749 4660 6615692 SGTC_1899 st063254 59.6 µM -1.88783876989632 0.0220821947271655 no 3249 0.0295237993140276 4628 3093813 SGTC_290 2043-6722 48.1 µM -1.90668443766455 0.0210303123856162 no 3250 0.0282807317090105 4665 773758 YLR208W SEC13 SGTC_516 3992-2719 87.3 µM -1.9159780778488 0.0205273916417353 no 3251 0.0276839430649308 4560 5350887 YDR037W KRS1 SGTC_2298 7976326 193.81 µM -1.91835050342617 0.0204006539356302 no 3252 0.0275332913277527 4634 2235818 SGTC_3269 9137823 49.47 µM -1.91931047625219 0.0203495598692029 no 3253 0.0274725264882987 4610 17682936 SGTC_1892 st058411 7.36 µM -1.92085183584534 0.0202677486918573 no 3254 0.0273751946582799 4657 3934738 SGTC_879 0831-1030 162 µM -1.92197184268937 0.0202084768419881 no 3255 0.027304650423661 4673 1549252 SGTC_1504 k297-0033 30 µM -1.92724437222455 0.0199314202270754 no 3256 0.0269745912576142 4599 4388117 SGTC_2556 citropten 84.59 µM -1.93412073917119 0.0195749347103135 no 3257 0.026549142289686 4641 2775 A potential DNA crosslinker. SGTC_1457 k015-0032 57.3 µM -1.93673631100322 0.0194407666969014 no 3258 0.0263887923599319 4672 4302660 SGTC_2982 9019404 25.97 µM -1.94175848833739 0.0191853391418108 no 3259 0.0260831722132705 4614 22333232 SGTC_1615 st002656 86.5 µM -1.94799878842419 0.0188719376912353 no 3260 0.0257075540614661 4668 1584458 SGTC_66 0109-0187 42.4 µM -1.95514672299942 0.0185183148553673 no 3261 0.0252828774101401 4506 759417 SGTC_141 0443-0274 32.331 µM -1.95981524253487 0.0182904125824178 no 3262 0.0250086945041324 4605 1627241 SGTC_74 000s-0487 160.283 µM -1.96638749163851 0.0179736292248571 no 3263 0.0246269336041399 4573 677548 SGTC_2993 9054257 71.4286 µM -1.96964422495459 0.0178183955338338 no 3264 0.0244395796840449 4609 6470217 YGL055W OLE1 SGTC_1190 1486-1332 13 µM -1.97005226249535 0.0177990270970027 no 3265 0.0244161905953869 4692 4150046 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.98006651408897 0.017329276373086 no 3266 0.0238480276170767 4645 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.99632505016224 0.0165891734382551 no 3267 0.0229492765442843 4672 229346 A bile salt which induces apoptosis. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.99838374652126 0.0164974177470371 no 3268 0.0228375361889034 4673 6312947 SGTC_2452 5863136 48.41 µM -2.00354798136395 0.0162691585298596 no 3269 0.0225592514477544 4652 2184096 SGTC_721 1187-1332 279 µM -2.00653015015783 0.0161385828297894 no 3270 0.0223998576498965 4691 25730 SGTC_1952 st077036 64.1 µM -2.00903107265419 0.0160297720321064 no 3271 0.0222669192707307 4688 2937007 SGTC_1985 st071382 65.5 µM -2.01496099553127 0.0157742816479442 no 3272 0.0219543680386028 4694 6123237 SGTC_2796 7949634 45.45 µM -2.02376192124821 0.0154015362215805 no 3273 0.0214973269756493 4650 2971588 SGTC_1018 4259-0013 28.1 µM -2.02433642878917 0.0153774692678379 no 3274 0.0214677739183243 4708 6801262 SGTC_1957 st077035 62.4 µM -2.03051507101481 0.0151206715629331 no 3275 0.0211521054062804 4698 705593 SGTC_1789 tunicamycin 25 nM -2.03858501332492 0.014790823376457 no 3276 0.0207457311042812 4631 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_922 1866-0035 480 µM -2.08279604812446 0.0130914796905495 no 3277 0.0186349089812795 4644 3156169 SGTC_3254 9136651 49.47 µM -2.11118293984411 0.0120916598281042 no 3278 0.0173782953129381 4684 16454030 SGTC_1319 1306-0155 43.7 µM -2.1140859900573 0.0119932433266073 no 3279 0.0172539617779892 4732 3122360 SGTC_2834 9001755 58.44 µM -2.11979667322494 0.0118016708175046 no 3280 0.0170115979941997 4581 2989575 SGTC_2841 9004761 38.96 µM -2.121291813083 0.0117519551000493 no 3281 0.0169486264540358 4648 2991039 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -2.12469185097754 0.0116395747329731 no 3282 0.0168061669392406 4709 688662 SGTC_709 3807-1509 243 µM -2.13174034030028 0.0114095717416137 no 3283 0.0165140992785519 4750 1886677 YPL242C IQG1 SGTC_2432 5630864 12.22 µM -2.13492459199156 0.0113069663087509 no 3284 0.016383585101913 4706 5714970 SGTC_1770 st043884 66.3 µM -2.13834015967651 0.0111977995749306 no 3285 0.0162445726882553 4723 670149 SGTC_765 1319-0117 244 µM -2.13850237344134 0.0111926378475161 no 3286 0.0162379958526707 4688 3487746 YGL099W LSG1 SGTC_2238 6671620 73.2395 µM -2.14474070300489 0.010995694175022 no 3287 0.0159867922934532 4633 729941 SGTC_614 0462-0418 107 µM -2.15167450191283 0.0107803387019661 no 3288 0.0157114998725749 4545 5188303 SGTC_2084 5306078 60.6385 µM -2.15552293837412 0.0106624027989508 no 3289 0.0155604677994672 4686 679340 SGTC_342 k048-0088 23.3 µM -2.15986218626793 0.010530775130665 no 3290 0.0153916699142461 4730 6820570 SGTC_1471 k673-0312 37 µM -2.17583746637948 0.0100583026237958 no 3291 0.0147837080328681 4738 24099884 SGTC_1415 3966-0071 78.1 µM -2.17597285693694 0.0100543787879183 no 3292 0.0147786451125574 4664 2893185 SGTC_1026 k007-1105 30.6 µM -2.17690868904535 0.0100272933800666 no 3293 0.0147436904987012 4685 7066794 SGTC_955 1216-0110 33 µM -2.18266029507425 0.00986222130051487 no 3294 0.0145304179698715 4692 3619719 SGTC_1171 0368-0077 21.4 µM -2.18576710722083 0.00977404624859048 no 3295 0.0144163241965347 4714 3239779 SGTC_1127 asiatic acid 681.4 nM -2.19033529766007 0.00964564640671497 no 3296 0.0142499643540224 4695 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_3231 9132313 49.47 µM -2.19352851397114 0.00955677110496455 no 3297 0.014134661257959 4724 4905967 SGTC_413 propylparaben 100 µM -2.23440287563147 0.00848081198619499 no 3298 0.0127282883347903 4719 7175 A pharmaceutical preservative. SGTC_1916 st067606 49.2 µM -2.24634521843323 0.00818721421114921 no 3299 0.0123409521548713 4646 19590279 SGTC_1120 ficusin 1.78878 µM -2.25679730208993 0.00793762048463449 no 3300 0.0120103717039683 4706 6199 A DNA cross-linker. SGTC_1943 st076331 65.2 µM -2.26247837596175 0.00780478450681534 no 3301 0.0118339316885924 4713 24208415 SGTC_3179 9107801 49.47 µM -2.29124895237843 0.00716166324923424 no 3302 0.0109745095921552 4741 4818259 SGTC_348 k064-0012 10.7 µM -2.30186056828184 0.00693653281962205 no 3303 0.0106715182724892 4723 5066323 SGTC_3004 9076122 71.4286 µM -2.32066716174085 0.00655285608834117 no 3304 0.0101524071711906 4727 44782551 SGTC_412 gemfibrozil 100 µM -2.32192400798045 0.00652789715277763 no 3305 0.0101185139158432 4728 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_860 0443-0016 25.1 µM -2.35458945115576 0.00590803111229896 no 3306 0.00927159003976951 4756 5337942 SGTC_55 0767-0285 6.563 µM -2.38409166193137 0.0053936540559728 no 3307 0.00856066860774236 4712 3116166 SGTC_2312 7706453 155.7 µM -2.39338482171453 0.00524008292597313 no 3308 0.00834686088728668 4728 976098 SGTC_244 nsc-207895 1.295 µM -2.40443748484747 0.00506250921751298 no 3309 0.00809868815786461 4708 42640 SGTC_836 0330-0104 1.35 µM -2.42248710316668 0.00478402101626296 no 3310 0.00770733645376821 4771 46494820 SGTC_824 1304-0008 100 µM -2.42700893409114 0.00471642924561684 no 3311 0.00761194047660232 4752 768245 SGTC_2522 biochanin a 4.94 µM -2.43090901451848 0.00465881689233485 no 3312 0.00753049806396657 4740 5280373 A possible chelator. SGTC_924 2046-0044 21.3 µM -2.4555167550421 0.00430957053877376 no 3313 0.00703410972261935 4740 3623589 SGTC_61 0978-8327 98.565 µM -2.46375801091519 0.00419794944745041 no 3314 0.00687444506074992 4718 6150059 YHR072W ERG7 SGTC_3216 9129716 49.47 µM -2.47687458768455 0.0040256226835173 no 3315 0.0066269232145717 4691 8056934 SGTC_2443 5493264 126.67 µM -2.48287925977464 0.00394886761837369 no 3316 0.00651626264860291 4778 5340055 SGTC_1128 3448-9350 235 µM -2.49766506036983 0.00376542610927373 no 3317 0.00625071249878789 4709 619386 SGTC_952 1185-0122 232 µM -2.50978659054925 0.00362077906646607 no 3318 0.00604020722187625 4730 678600 SGTC_710 3448-4187 58 µM -2.51494301147601 0.00356077376348015 no 3319 0.00595258129667032 4736 3946412 SGTC_2570 licareol 100 µM -2.58788151268351 0.00280253958655504 no 3320 0.0048284095835687 4734 443158 SGTC_2161 5662504 8.5105 µM -2.59402065572727 0.00274590285180205 no 3321 0.00474303938133029 4781 2859334 SGTC_3305 9127027 53.8275 µM -2.60730538644748 0.00262686601327119 no 3322 0.0045628964927427 4752 41905295 SGTC_2026 5148700 152 µM -2.60873727008011 0.00261431811213244 no 3323 0.00454384928681829 4764 79838 SGTC_3011 9081274 71.4286 µM -2.63379712811834 0.00240330474402721 no 3324 0.00422179607673575 4775 6625322 SGTC_2543 pimpinellin 60.67 µM -2.67254167594704 0.00210726773384631 no 3325 0.00376395115089053 4720 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_948 3448-0295 75.3 µM -2.74188278521886 0.00165876213735115 no 3326 0.00305440683030404 4772 678569 SGTC_2423 st077119 87.2 µM -2.74268901076709 0.00165410218666815 no 3327 0.00304691839994946 4719 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2888 9058547 12.99 µM -2.74786762754176 0.00162445318060824 no 3328 0.00299921104805828 4756 16476514 SGTC_3283 9109332 35.8195 µM -2.77533509500468 0.00147513535576897 no 3329 0.00275724285095319 4718 17027281 SGTC_954 1189-0853 2.85 µM -2.78972520949351 0.00140201074018788 no 3330 0.00263763967781837 4746 2828194 SGTC_471 1-acyl-paf 4 µM -2.81844329439031 0.00126588174673528 no 3331 0.00241285670477841 4774 16759367 SGTC_2406 ethylparaben 405.7 µM -2.86078539658563 0.00108712512591407 no 3332 0.00211296501025539 4752 8434 A possible steroid mimic. SGTC_2360 9040895 200 µM -2.92425031525088 0.000862171629255404 yes 3333 0.00172643481074913 4787 4914414 SGTC_1355 1499-0035 1.68 µM -2.98601231041081 0.000685131451732827 yes 3334 0.00141320632428872 4795 1548538 SGTC_708 3448-5400 146 µM -3.01247293951907 0.000620087832112892 yes 3335 0.00129564269010772 4783 3462195 SGTC_2000 st075254 36.4 µM -3.02503484004414 0.000591249118351932 yes 3336 0.00124302243997767 4783 17234175 SGTC_2666 tannic acid 100 µM -3.04421485108757 0.000549599519124668 yes 3337 0.00116644234121137 4791 16134267 A thiamine antagonist. SGTC_1459 k035-0031 35.7 µM -3.05387689441526 0.000529661879710393 yes 3338 0.00112952380352626 4734 3877128 YMR208W ERG12 SGTC_1947 st076332 61.6 µM -3.05836950901067 0.000520621149253107 yes 3339 0.00111272489198753 4762 24208416 SGTC_2890 9046729 58.44 µM -3.10007946493799 0.000443246939404561 yes 3340 0.000967343647617084 4794 903329 SGTC_711 k292-0785 179 µM -3.16220141049792 0.00034756332645845 yes 3341 0.000782906116788371 4774 4146315 SGTC_2405 ticlatone 3.52 µM -3.29886283644821 0.000200539231148905 yes 3342 0.000485386664590468 4726 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2614 arthonioic acid 13.39 µM -3.31370126344864 0.000188681007863336 yes 3343 0.000460349092161675 4745 6710684 SGTC_1036 k216-0215 33.5 µM -3.3898783293669 0.000137456643591677 yes 3344 0.000349618252553264 4797 622330 SGTC_2937 9044753 11.33 µM -3.46778008635032 9.87645617536231e-05 yes 3345 0.000262388275466183 4789 6465530 YGL099W LSG1 SGTC_1926 methyl fluorone black 53.6 µM -3.53798454902716 7.28980366945172e-05 yes 3346 0.000201596825574432 4694 72721 Reacts with homocysteine. SGTC_2933 9026794 32.47 µM -3.70831767211138 3.41060328536938e-05 yes 3347 0.000104320404352421 4796 17586027 SGTC_3212 9128307 49.47 µM -3.7405797508895 2.94284167212665e-05 yes 3348 9.17981391364837e-05 4774 27243542 SGTC_2803 7707263 71.43 µM -3.96423155297188 1.02507582079571e-05 yes 3349 3.68163772032861e-05 4801 2199229 SGTC_1349 flufenamic acid 69 µM -4.49019903143979 6.87831995413627e-07 yes 3350 3.55783263846385e-06 4805 3371 A non-steroidal anti-inflammatory. SGTC_1107 amlodipine 47 µM -4.94800366889228 5.07880944412614e-08 yes 3351 3.74892480369934e-07 4720 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_470 aa-861 153 µM -5.31259043597113 5.37675714742721e-09 yes 3352 5.40388799912872e-08 4810 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.