SGTCid condition conc unit MSK1|YNL073W.score MSK1|YNL073W.strain.pval MSK1|YNL073W.strain.significant MSK1|YNL073W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_310 1273-0058 1.06 µM 12.0020965661658 9.52558784344822e-30 yes 1 1.73204314900718e-33 22 2734232 SGTC_236 1509-0011 5.31 µM 8.30996688502811 2.94428052703558e-15 yes 2 4.78643917751017e-17 240 3107280 SGTC_2688 kanamycin b 96.69 µM 6.08879505937699 5.19462164862613e-09 yes 3 5.68818167599635e-10 154 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2526 patulin 37.61 µM 6.08021238823474 5.44651072596863e-09 yes 4 6.00117296414272e-10 25 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_63 0099-0242 26.702 µM 5.52984515869952 9.9480894231702e-08 yes 5 1.60256785856908e-08 36 3898502 YLR359W ADE13 SGTC_1742 st038235 28.8875 µM 5.52638472759138 1.01231825945478e-07 yes 6 1.63448434607996e-08 60 564103 YBR002C RER2 SGTC_1074 carmofur 3.8 µM 5.50818451589989 1.10942412647926e-07 yes 7 1.81276641164369e-08 6 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 5.14013969701731 6.65707647366642e-07 yes 8 1.37267140870406e-07 10 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_173 1273-0061 2.693 µM 5.10838437690802 7.72831457765987e-07 yes 9 1.62462569313076e-07 142 2847414 YPL266W DIM1 SGTC_932 2857-0803 154 µM 4.89362592821443 2.07294815208013e-06 yes 10 4.94974602556957e-07 16 674898 SGTC_1063 disulfiram 1.84 µM 4.6789658511875 5.3452315728994e-06 yes 11 1.44162726702931e-06 10 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_10 0279-0212 42.575 µM 4.57160849666568 8.46006693491712e-06 yes 12 2.41997289617638e-06 88 39851 YBR002C RER2 SGTC_70 0141-0289 43.283 µM 4.4965834436725 1.15937576461279e-05 yes 13 3.45270432458572e-06 138 352408 SGTC_2682 pyrogallin 40.03 µM 4.38971911852076 1.80136638857721e-05 yes 14 5.67485821011468e-06 18 822798 An ATP competetive kinase inhibitor. SGTC_832 4083-0019 164 µM 4.30965811224949 2.49029163687268e-05 yes 15 8.17535618021833e-06 69 1990758 SGTC_1240 0356-0016 42.1 µM 4.21778187916983 3.58739121746783e-05 yes 16 1.23358650993913e-05 31 4305613 SGTC_908 3448-7491 47.7 µM 4.19386209792064 3.940465877425e-05 yes 17 1.37122370943493e-05 109 1203031 SGTC_2278 7948257 134.34 µM 4.12087006449871 5.2320276079955e-05 yes 18 1.88722132173393e-05 20 1247028 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 3.95204899424433 9.90906320684005e-05 yes 19 3.87424354326028e-05 49 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1106 tegaserod maleate 11.7 µM 3.93134123177831 0.000106990102192021 yes 20 4.22366370251961e-05 16 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2603 homopterocarpin 100 µM 3.91513762817724 0.000113579766869295 yes 21 4.51763267284369e-05 41 101795 A weak amylase inhibitor. SGTC_2008 4012253 172 µM 3.89535508340098 0.000122141421697194 yes 22 4.9027487228582e-05 28 603940 SGTC_1960 st011366 51.8 µM 3.89412592621223 0.00012269287955729 yes 23 4.92767231289336e-05 9 3972846 SGTC_2646 retinol 96.75 µM 3.8809232601517 0.000128765337328741 yes 24 5.2030337307601e-05 12 445354 A vitamin A analog and teratogen. SGTC_735 3076-0345 636 µM 3.87196150436237 0.000133046580001492 yes 25 5.39815031836605e-05 29 2888990 SGTC_68 0986-0284 82.829 µM 3.82641056357948 0.000156947915388109 yes 26 6.50126799092119e-05 76 423278 YIL048W NEO1 SGTC_283 0987-0079 11.7 µM 3.82428970049153 0.00015815323909039 yes 27 6.55748170744416e-05 29 411556 SGTC_116 0155-0182 31.788 µM 3.75257424137287 0.000204396150329621 yes 28 8.75139867749708e-05 94 771486 SGTC_2642 cholecalciferol 100 µM 3.6036429401009 0.000343471930321775 yes 29 0.000156894026275792 26 9821465 A vitamin D precursor, similar to steriods. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 3.59763965118119 0.000350598915742501 yes 30 0.000160559044525122 35 4330530 SGTC_275 trichlorophene 5.69 µM 3.59373450725292 0.000355308542274628 yes 31 0.000162985996600047 245 62616 SGTC_2460 5552655 174.22 µM 3.56524536043782 0.0003914865863497 yes 32 0.00018175797576869 38 5401989 SGTC_2295 7971645 200 µM 3.53635460631474 0.000431642862496899 yes 33 0.000202844870887596 34 2978226 YKL099C UTP11 SGTC_1187 1391-0724 117 µM 3.53383322325564 0.00043532280389297 yes 34 0.00020478971705369 28 6997986 SGTC_1627 st003713 25.6 µM 3.51255931572947 0.000467550147046144 yes 35 0.000221906463289777 100 16195070 YER133W GLC7 SGTC_2543 pimpinellin 60.67 µM 3.48996528145287 0.000504187691303776 yes 36 0.000241541651390968 27 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2812 7970281 58.44 µM 3.43811750089576 0.00059853187229884 yes 37 0.000292886728353467 54 2233435 SGTC_2518 prenyletin 46.28 µM 3.43178928362752 0.000611102239998431 yes 38 0.000299806625632801 21 3873459 A coumarin with calcium channel inhibitory activity. SGTC_767 0929-0023 86 µM 3.38152630895833 0.00071994817251837 yes 39 0.000360421648605039 117 1204563 SGTC_2523 spermine 47.74 µM 3.36508228286368 0.000759268051896495 yes 40 0.000382604177720499 44 1103 A DNA binding polyamine. SGTC_2940 9060638 45.86 µM 3.35041107559527 0.000796008822675208 yes 41 0.000403458565946602 49 4027022 SGTC_28 pentachloropyridine N-oxide 1.606 µM 3.34237681396607 0.00081681566269779 yes 42 0.000415321076557214 106 140250 A respiratory chain inhibitor. SGTC_1695 st026914 34.495 µM 3.30859124684143 0.000909905728377836 yes 43 0.000468833121366334 42 3289191 SGTC_1824 st053723 68.6 µM 3.23720882618316 0.00113944332107378 no 44 0.000603525241445498 60 675225 SGTC_1705 st027868 56.3335 µM 3.23066202361407 0.00116295311691248 no 45 0.000617519417455891 30 292948 SGTC_933 2914-0560 114 µM 3.19429238901875 0.0013018410042694 no 46 0.000700870336656823 55 463887 SGTC_2512 diallyl trisulfide 49.23 µM 3.17086819852316 0.00139915421559788 no 47 0.000759920425248835 27 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_593 1203-0218 61.7 µM 3.15971334991294 0.00144779218894727 no 48 0.000789622144132907 32 3666956 SGTC_1150 3909-7983 10.9 µM 3.12969192389253 0.00158645715497032 no 49 0.000874948596597238 61 23965914 SGTC_390 dec-rvkr-cmk 16.7 µM 3.10910786073702 0.00168841506670451 no 50 0.000938265996441057 68 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_120 rhodamine 6G 52.259 µM 3.09933473723887 0.00173888246923969 no 51 0.000969778748671553 81 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1883 5-benzylidenerhodanine 20 µM 3.09632006455254 0.00175472473298619 no 52 0.000979693701067585 128 1273210 SGTC_100 0086-0128 49.5915 µM 3.06380458693197 0.00193413729882373 no 53 0.00109270805141366 101 93297 SGTC_2743 auranofin 4.32 µM 3.06286953168228 0.00193953481709919 no 54 0.00109612808516859 73 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_19 0279-0214 38.434 µM 2.99790569882228 0.00234978029946802 no 55 0.00135920886910118 112 3566274 YBR002C RER2 SGTC_744 1594-0068 283 µM 2.98481128265486 0.00244142467808993 no 56 0.00141876662992575 77 668392 SGTC_456 gingerol 170 µM 2.98381059634186 0.00244855948564468 no 57 0.00142341467753029 62 442793 A herb. SGTC_800 3448-7362 155 µM 2.96792520701633 0.00256437553973052 no 58 0.00149908637662962 280 15991913 SGTC_1188 1403-0014 4.57 µM 2.95052181809716 0.00269692315133611 no 59 0.00158618818878484 116 9614867 SGTC_118 0083-0097 135.343 µM 2.8678531657678 0.00341491908764046 no 60 0.00206633640657876 289 5207356 SGTC_1129 3453-1384 223 µM 2.86272748549687 0.00346463447833593 no 61 0.00210005817463725 106 1084452 SGTC_2069 5228469 200 µM 2.86175847252664 0.00347410594849774 no 62 0.00210648912487797 60 2835210 SGTC_3058 9093861 49.47 µM 2.85964708149726 0.00349482401183776 no 63 0.00212056348733436 75 17217477 SGTC_386 1509-0011 3.07 µM 2.83180027182755 0.00377864425260041 no 64 0.00231433754942838 214 3107280 SGTC_1155 4088-0394 48.2 µM 2.80838518411987 0.00403310647117873 no 65 0.00248953167758715 85 2326248 SGTC_33 0986-0033 35.816 µM 2.79820739808521 0.00414841836417325 no 66 0.00256935524607426 60 2848082 SGTC_1683 st010134 710 nM 2.79504748857251 0.00418481468641 no 67 0.00259460459694325 100 3818134 SGTC_1862 st057513 3.81 µM 2.78117376729571 0.00434801704078695 no 68 0.00270813686845188 65 5393163 SGTC_2140 5586273 200 µM 2.77061664871298 0.00447599129847717 no 69 0.00279751277658739 47 854421 SGTC_2498 4'-Methoxychalcone 54.63 µM 2.74389126803825 0.0048151192724939 no 70 0.00303578223858939 88 641818 YHR062C RPP1 SGTC_946 3434-1334 87.4 µM 2.73593700675863 0.00492038458893388 no 71 0.00311014661050757 96 4047976 SGTC_1315 1237-0019 3.69 µM 2.7260000289532 0.00505476682291965 no 72 0.00320534963626595 60 825140 SGTC_1896 st058441 89 µM 2.70429476571524 0.00535972025643891 no 73 0.00342247695504237 73 688759 SGTC_1175 0741-0056 27.6 µM 2.69957909306329 0.00542809830767513 no 74 0.00347136253997638 98 765927 SGTC_2296 7971656 126.45 µM 2.69950765796007 0.00542914006354702 no 75 0.00347210787880564 118 666570 SGTC_886 0866-0150 153 µM 2.68865356416692 0.00558950785708658 no 76 0.0035870414836602 93 271463 SGTC_697 0508-1955 564 µM 2.67745256529584 0.00575939872200657 no 77 0.00370921780218657 113 6243113 SGTC_3308 9128332 17.569 µM 2.67548148154529 0.00578976473337583 no 78 0.0037310997806858 176 17332805 YDL196W YDL196W SGTC_1614 st002383 48.6 µM 2.66959132709414 0.00588135522377662 no 79 0.00379718085777573 88 1947235 SGTC_436 n,n-dimethylsphingosine 3.3 µM 2.66415060421941 0.00596709656704234 no 80 0.00385914995594699 105 5282309 SGTC_503 tyrphostin 8 294 µM 2.64772462798022 0.00623271825677218 no 81 0.00405177518690336 115 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1414 3917-0015 5.4 µM 2.6455100492986 0.00626931938448669 no 82 0.00407839320818429 73 6618702 SGTC_3069 9117009 49.47 µM 2.6247258192866 0.00662220961864441 no 83 0.00433593834391794 51 41904981 SGTC_2078 5212016 200 µM 2.6224734503515 0.00666148729315838 no 84 0.0043647034480349 66 1899708 SGTC_2583 asiatic acid 100 µM 2.62169410008113 0.00667512577747395 no 85 0.00437469620512127 104 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1882 5615643 20 µM 2.6188490001043 0.00672512423461723 no 86 0.00441134957729361 85 2253075 SGTC_2932 9016711 44.54 µM 2.60978516824578 0.00688662130919813 no 87 0.00452995494953238 148 7117328 SGTC_1570 verbenone 133 µM 2.60675693257312 0.00694133582741527 no 88 0.00457021099500074 93 29025 A natural terpanoid with antifungal properties. SGTC_2488 5268135 45.7 µM 2.5857126945919 0.00733228029009491 no 89 0.00485889476145327 144 1270356 YLR208W SEC13 SGTC_1825 st052143 62.6 µM 2.57382830744145 0.00756152896036368 no 90 0.00502900856428317 82 674173 SGTC_915 methyl methanesulfonate (MMS) 110 mM 2.57151966002097 0.00760678764894015 no 91 0.00506266331078083 125 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_582 0987-0078 156 µM 2.55896879929749 0.00785703177231817 no 92 0.00524915816372648 214 1625765 SGTC_2657 nystatin 74.44 µM 2.55556550368837 0.00792612410538683 no 93 0.00530077025830613 91 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2570 licareol 100 µM 2.54221484885172 0.00820234973767809 no 94 0.00550762202586318 129 443158 SGTC_1446 4239-0190 62 µM 2.52552516225708 0.00855952878009826 no 95 0.00577627540938487 136 1340085 SGTC_2390 9097792 176.6 µM 2.51004416481716 0.00890296601485136 no 96 0.00603580313926248 98 4497149 SGTC_3352 9151559 45.5865 µM 2.49540118985822 0.00923886341303182 no 97 0.00629073952995222 91 17159339 SGTC_2476 5806916 10.51 µM 2.4913846979312 0.00933291522206176 no 98 0.00636231303275312 98 2870194 SGTC_1755 st041960 45.185 µM 2.48215266563256 0.00955227765287305 no 99 0.00652956561284163 118 2257073 SGTC_2077 5212015 200 µM 2.47805804143767 0.00965100427727776 no 100 0.00660498271008397 160 780900 SGTC_2556 citropten 84.59 µM 2.47614596724348 0.00969741146354739 no 101 0.00664046341327409 153 2775 A potential DNA crosslinker. SGTC_211 3455-0679 143.504 µM 2.46805424151678 0.00989596769806263 no 102 0.00679248663009579 127 748649 SGTC_947 3447-0010 211 µM 2.44926498513331 0.0103707652447236 no 103 0.00715740462064316 114 748350 SGTC_1807 st050092 58.9 µM 2.44433423788098 0.0104986062539991 no 104 0.00725598755598687 120 5008496 SGTC_1693 xanthone 101.9 µM 2.43808664907189 0.0106625601391888 no 105 0.00738261714409445 111 7020 An insecticide. SGTC_442 cape 100 µM 2.43711482030117 0.0106882629885781 no 106 0.00740248876477695 91 5281787 SGTC_148 3253-0744 288.01 µM 2.42579788556905 0.0109915677114598 no 107 0.0076373871957841 122 6893655 SGTC_1461 k072-0203 53.8 µM 2.41833821725567 0.0111955644042402 no 108 0.00779578857039039 113 5418714 SGTC_1871 st057448 67.3 µM 2.41225692366529 0.0113642948720456 no 109 0.00792705255589706 135 691747 SGTC_141 0443-0274 32.331 µM 2.40772074780178 0.0114915895229475 no 110 0.0080262271734547 215 1627241 SGTC_2555 cholic acid 100 µM 2.38790625620972 0.0120622523321629 no 111 0.00847233166614086 103 6708657 Influences liver metabolism. SGTC_2139 5578692 56.4705 µM 2.38491570784662 0.0121504808019815 no 112 0.00854151753104407 95 650991 YMR113W FOL3 SGTC_1623 st003709 20.3 µM 2.37974161007121 0.0123044507610306 no 113 0.00866239072624237 232 16192618 SGTC_1664 st014217 9.02 µM 2.37787083236865 0.0123605356647672 no 114 0.00870646217420195 117 3982782 SGTC_2598 perillyl alcohol 100 µM 2.37674522837417 0.0123943872545699 no 115 0.00873307358313984 162 10819 An apoptosis inducer. SGTC_2306 7482397 179.52 µM 2.37619929080908 0.0124108347635511 no 116 0.00874600624377367 132 891448 SGTC_1881 5652484 16 µM 2.36832530597231 0.0126501657362564 no 117 0.00893440839132078 147 2255129 SGTC_1167 k781-0610 148 µM 2.35837026871109 0.0129584598163299 no 118 0.00917768715915994 154 4525169 SGTC_101 0490-5701 117.494 µM 2.34291407061553 0.0134499877820791 no 119 0.00956689464367971 107 4661669 SGTC_2533 agelasine 13.65 µM 2.33103491709021 0.0138386233350763 no 120 0.00987575929043963 185 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_440 fluspirilene 35.1 µM 2.3265982733807 0.0139862355392692 no 121 0.00999332826464114 159 3396 An atypical antipsychotic. SGTC_1313 1220-0047 237 µM 2.31871679414019 0.014251809975076 no 122 0.010205198654242 180 3528706 SGTC_357 1325-0123 420 µM 2.31640963855796 0.0143303691743701 no 123 0.0102679564936162 113 1098503 SGTC_1912 st060209 90.8 µM 2.30596597432678 0.0146906601456994 no 124 0.010556266824807 159 688787 SGTC_614 0462-0418 107 µM 2.29890122223154 0.0149387790130561 no 125 0.0107552744973974 172 5188303 SGTC_2205 7238770 200 µM 2.29492835003658 0.0150798852460229 no 126 0.0108686153981797 103 279867 SGTC_2505 galangin 7.89 µM 2.27938830672902 0.0156428834917973 no 127 0.0113219964025383 99 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2233 sulbentine 40.3845 µM 2.26529830334791 0.016168843606388 no 128 0.0117471900490175 220 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2176 5809774 33.9695 µM 2.26294466609811 0.0162581623895216 no 129 0.0118195502578731 130 2870539 SGTC_2750 bromebric acid 70.15 µM 2.22306768621299 0.0178369222095831 no 130 0.0131056180959753 196 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_93 0109-0045 59.227 µM 2.21890324565027 0.0180090968903051 no 131 0.0132466538334606 207 88733 SGTC_1289 0976-0073 69.1 µM 2.21650673411145 0.0181088191632816 no 132 0.0133284086010175 148 3391136 SGTC_3231 9132313 49.47 µM 2.20682493380566 0.018516498379371 no 133 0.0136631461972539 143 4905967 SGTC_2263 7948595 193.29 µM 2.19728685356237 0.0189257418643593 no 134 0.0139999829801764 112 2971371 SGTC_133 0724-0033 378.92 µM 2.18608921270739 0.0194159850488433 no 135 0.0144045395256097 147 280309 SGTC_2430 5571206 200 µM 2.18599707320169 0.0194200633372157 no 136 0.0144079097285141 215 1731771 SGTC_3193 9111931 49.47 µM 2.17779173444464 0.0197861787094399 no 137 0.0147107727748976 172 17087244 SGTC_2041 5107442 45.335 µM 2.16723401162963 0.0202658595710366 no 138 0.0151085076111357 203 793005 SGTC_1353 1498-1206 8.11 µM 2.16631885880813 0.0203078991831468 no 139 0.0151434147934493 242 6756808 SGTC_355 1311-2252 105 µM 2.15050420486681 0.0210461391501686 no 140 0.0157576768731792 204 5338538 SGTC_305 1682-2595 20.8 µM 2.14471943595389 0.0213217902159882 no 141 0.0159876429786886 181 226033 SGTC_3310 9130229 44.1445 µM 2.1370170530598 0.0216935513424444 no 142 0.0162983023152806 185 7761258 SGTC_777 1315-0167 517 µM 2.13261918404129 0.0219082632952914 no 143 0.0164779891489399 176 4221767 SGTC_290 2043-6722 48.1 µM 2.12680497232461 0.0221948757106899 no 144 0.0167181455000969 178 773758 YLR208W SEC13 SGTC_2691 st077356 60.2 µM 2.12459791412866 0.0223044983627695 no 145 0.0168100890354794 204 2839272 SGTC_418 lividomycin a 100 µM 2.12428079661088 0.0223202867804359 no 146 0.0168233352606347 158 72394 An antibiotic. SGTC_2902 5787006 60.46 µM 2.12020758039402 0.0225239207841773 no 147 0.0169942717162524 180 591003 SGTC_119 0121-0043 24.815 µM 2.11713272576303 0.022678678919323 no 148 0.0171242924771686 371 1092378 SGTC_1805 st050013 60.3 µM 2.11653862235188 0.022708683360932 no 149 0.0171495119967076 146 4037144 SGTC_2232 chlorophetanol 41.5365 µM 2.11221081170623 0.0229282650948302 no 150 0.0173341857960332 321 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1413 3910-0535 34.4 µM 2.10664255678364 0.0232134122720925 no 151 0.0175742874615056 172 2876951 SGTC_264 promethazine 12.5 mM 2.10612998460376 0.0232398102070877 no 152 0.0175965314431384 289 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1168 k815-0004 80.5 µM 2.10540221472742 0.0232773344265722 no 153 0.0176281555910644 179 642433 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 2.09775112054083 0.0236749245564566 no 154 0.0179635682202932 171 7104 SGTC_609 0986-0026 86.3 µM 2.09238395343102 0.0239572254292837 no 155 0.0182020915325436 226 2848610 SGTC_671 0560-0003 407 µM 2.08331967544896 0.0244404076431737 no 156 0.0186110472327781 169 3238678 SGTC_778 3456-2434 196 µM 2.08191396155121 0.0245160686916463 no 157 0.0186751646406182 285 5539063 SGTC_1621 st003705 32.4 µM 2.06393322410653 0.0255013249320301 no 158 0.0195120240536596 224 24207032 SGTC_2740 felodipine 17.08 µM 2.05911689472613 0.0257707971180953 no 159 0.0197415208798642 146 3333 L-type calcium channel blocker SGTC_330 1488-0319 80.1 µM 2.05370357889441 0.0260765109350791 no 160 0.0200021949803958 183 6846614 SGTC_2183 6420625 130.508 µM 2.05334398645815 0.0260969256898333 no 161 0.0200196138275488 297 2897619 SGTC_1784 st039334 36.3 µM 2.05066358576673 0.0262495187214571 no 162 0.0201498597315441 209 3496984 SGTC_831 k061-1017 217 µM 2.04987001090527 0.0262948391517712 no 163 0.0201885586811447 349 1240153 SGTC_3096 9117468 49.47 µM 2.04693939789942 0.0264627713113009 no 164 0.020332017582305 122 41316311 SGTC_2515 chrysin 20.77 µM 2.0423531600226 0.0267273734520072 no 165 0.0205582562250487 173 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2982 9019404 25.97 µM 2.03279626671305 0.0272858601179122 no 166 0.0210365552395011 206 22333232 SGTC_343 4130-2827 29.8 µM 2.03072084041415 0.0274084219385346 no 167 0.0211416605153535 224 1118244 SGTC_2079 5212404 121 µM 2.03003994848959 0.027448731073065 no 168 0.0211762393868964 182 758462 SGTC_2052 5265182 7.135 µM 2.01168666745308 0.0285540171649975 no 169 0.0221264884616212 220 1239884 SGTC_1615 st002656 86.5 µM 2.00217077153562 0.0291415121864296 no 170 0.0226331840377301 197 1584458 SGTC_365 0121-0052 13.6 µM 2.00114408989247 0.0292054936689772 no 171 0.0226884320597143 325 3101739 SGTC_3269 9137823 49.47 µM 1.99720949936378 0.0294517737000027 no 172 0.0229012147833729 197 17682936 SGTC_1371 2421-0008 32.7 µM 1.99439308617083 0.0296291198349985 no 173 0.0230545567479012 279 2827552 SGTC_2160 5660466 132.927 µM 1.99290903927323 0.0297229244421492 no 174 0.0231357041666618 202 2859134 SGTC_1172 0370-0043 85 µM 1.98943854468162 0.0299432519487082 no 175 0.0233264093735122 194 376585 SGTC_370 0180-0345 38.7 µM 1.98700862776218 0.0300983222674868 no 176 0.0234607203760325 196 3989527 SGTC_154 3389-1638 511.116 µM 1.98478146431023 0.0302410376742216 no 177 0.023584395303225 221 5238686 SGTC_2874 9043904 71.43 µM 1.97962126250784 0.0305738566584556 no 178 0.0238730509836978 162 4463428 SGTC_2831 7999036 19.48 µM 1.97802094673727 0.0306776869077454 no 179 0.0239631718331433 273 2988270 SGTC_2337 9009472 200 µM 1.97772750563539 0.0306967573322869 no 180 0.0239797277771869 276 5742383 SGTC_1552 6-methylflavone 10.6 µM 1.97077748333569 0.031151309036259 no 181 0.0243746666457649 168 689013 SGTC_204 PMA1.184 62.41 µM 1.96787567583054 0.0313427364791056 no 182 0.0245411720867654 243 2252213 YGL008C PMA1 SGTC_3272 9137413 49.47 µM 1.95481826078405 0.0322161865919675 no 183 0.0253022625157142 218 17614870 SGTC_2821 7996764 71.43 µM 1.95443721289865 0.0322419747391482 no 184 0.0253247667107923 286 2987135 SGTC_2525 harmine 47.85 µM 1.95416571117196 0.0322603595323949 no 185 0.0253408114797106 169 5280953 A monoamine oxidase inhibitor SGTC_1365 1672-3266 55.4 µM 1.94874889570883 0.0326289722101815 no 186 0.025662709717945 241 6415873 SGTC_2960 9079389 5.97 µM 1.94771384917099 0.0326998005970416 no 187 0.0257246060251265 243 16457355 SGTC_2363 9053361 176 µM 1.94410966261404 0.0329474256138572 no 188 0.0259411141500883 260 6469797 YMR079W SEC14 SGTC_891 0929-0073 133 µM 1.93697706874037 0.0334420251525247 no 189 0.0263740732632786 212 5603632 SGTC_1836 st055642 81 µM 1.93202036381205 0.0337893283140304 no 190 0.0266784962391753 265 8571 SGTC_1334 1486-0610 236 µM 1.92899174192406 0.0340029925285845 no 191 0.0268659437139222 248 3742339 SGTC_3009 9080819 71.4286 µM 1.92516371123401 0.0342746421536296 no 192 0.0271044402082363 237 17027216 SGTC_877 0771-0151 33.1 µM 1.91901187435035 0.0347149314840781 no 193 0.0274914155483771 244 6166523 SGTC_734 2023-0417 80 µM 1.91892679069996 0.0347210533641871 no 194 0.0274967997805423 238 3935732 SGTC_3271 9137798 49.47 µM 1.91308089823327 0.0351438007368838 no 195 0.0278688483673252 170 6498326 SGTC_871 0574-0004 149 µM 1.91236104344829 0.0351961480510703 no 196 0.0279149505489293 288 9551173 SGTC_2445 5742597 35.57 µM 1.91065559590535 0.0353204222785212 no 197 0.0280244273433962 225 1774255 SGTC_1839 st053978 48 µM 1.90588061161693 0.0356702860862403 no 198 0.0283328485371188 245 3788398 SGTC_1118 chelidonine 707.474 nM 1.90506326151516 0.0357304572159 no 199 0.0283859241425019 256 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_944 3370-0224 231 µM 1.90491747602815 0.0357411982901895 no 200 0.0283953995863197 255 4580514 SGTC_3152 9099253 49.47 µM 1.89919730246566 0.036164738170471 no 201 0.0287692696474091 398 25236131 SGTC_2422 chlorphenesin carbamate 384.24 µM 1.89180784347703 0.036717951637008 no 202 0.0292582939401973 317 2724 A muscle relaxant with antifungal properties. SGTC_1624 st003710 6.25 µM 1.88955716998034 0.0368878173857102 no 203 0.0294086049613646 307 24207033 SGTC_235 0330-0087 5 mM 1.87825640914287 0.0377504608951649 no 204 0.0301730483466684 285 46494818 YHR062C RPP1 SGTC_588 3970-1144 52.9 µM 1.87820413931096 0.0377544888429518 no 205 0.0301766220641394 276 1888707 SGTC_3251 9135047 49.47 µM 1.87183125834498 0.038248222190177 no 206 0.0306149761310396 183 17682963 SGTC_161 4065-0411 162.148 µM 1.8651650859473 0.0387702991289005 no 207 0.0310791338893038 347 1906281 YLR208W SEC13 SGTC_468 gf-109203x 121 µM 1.86301023633969 0.038940297510792 no 208 0.0312304130314724 140 2396 A protein kinase C inhibitor. SGTC_1845 st056753 3.01 µM 1.86161748686035 0.0390504955894529 no 209 0.0313285133213802 295 5375839 SGTC_1813 st051246 8.6015 µM 1.86030531550814 0.0391545502631866 no 210 0.0314211709734026 203 5291959 SGTC_1759 st043059 70 µM 1.85730920363012 0.0393929868457456 no 211 0.0316335878743224 273 669426 SGTC_914 3820-6779 408 µM 1.85680323502973 0.0394333691936386 no 212 0.0316695766536604 265 2893481 SGTC_1964 st076914 61 µM 1.84346509968218 0.0405101131390071 no 213 0.0326305664004858 225 24208661 SGTC_3190 9110366 49.47 µM 1.84298646168759 0.0405491913024022 no 214 0.0326654935835241 205 17123768 SGTC_900 1112-0045 141 µM 1.84017379459675 0.0407794488065054 no 215 0.0328713629914624 195 56211 YIL048W NEO1 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.84013731126518 0.040782442450529 no 216 0.0328740403500971 241 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2565 isoliquiritigenin 100 µM 1.83945151365761 0.0408387488405279 no 217 0.0329244016149443 236 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_862 0452-0056 10.2 µM 1.83759024685543 0.0409918833039213 no 218 0.0330614035305309 249 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2951 9072950 58.06 µM 1.83127650362108 0.0415148148490398 no 219 0.0335296414273686 290 16488155 SGTC_3178 9107506 49.47 µM 1.83061139198271 0.0415702155672852 no 220 0.0335792834916232 261 8897194 SGTC_605 1315-0399 119 µM 1.82930581332558 0.0416791383996335 no 221 0.0336769041394647 305 24020461 SGTC_1870 st057514 26.5 µM 1.82911529339753 0.0416950525558158 no 222 0.0336911691916703 269 5393161 SGTC_1626 st003712 1.76 µM 1.82660038496147 0.041905584842682 no 223 0.0338799377335356 264 24207035 SGTC_2747 doxorubicin 7.63 µM 1.81028042793895 0.0432927872504327 no 224 0.0351261553104468 142 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3259 9138485 49.47 µM 1.80662479441372 0.0436085460619705 no 225 0.0354104004393715 301 17646153 SGTC_2678 equilin 100 µM 1.80450431305227 0.0437925547035103 no 226 0.0355761418175277 288 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_439 amiodarone 34.4 µM 1.80237684062113 0.0439777989719474 no 227 0.035743068190786 364 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_802 4112-3352 742 µM 1.79794375120336 0.0443658292476938 no 228 0.0360929609696576 317 704594 SGTC_2022 5136654 200 µM 1.79604916595071 0.0445325024821516 no 229 0.0362433490106463 296 1713771 SGTC_2250 alverine citrate 130 µM 1.7943562751739 0.0446818583522638 no 230 0.0363781606033043 503 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2550 chrysin dimethyl ether 71.87 µM 1.7893654787685 0.0451245220407625 no 231 0.036777987556417 177 88881 An O-methylated flavonoid and antioxidant. SGTC_3030 9087619 49.47 µM 1.78244419751385 0.045744245198959 no 232 0.0373384117443145 282 25236973 SGTC_2908 7930301 100 µM 1.7818161398746 0.0458008176297078 no 233 0.0373896096935878 338 2223178 SGTC_601 0986-0029 62.9 µM 1.77749044356475 0.0461919845117235 no 234 0.0377437908912447 338 24747981 SGTC_192 3455-0609 60.9 µM 1.7686304516985 0.0470015559046499 no 235 0.0384777827438947 281 3769639 SGTC_2745 rifampicin 24.3 µM 1.76811866115611 0.0470486655813855 no 236 0.0385205341740406 158 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_54 0159-0055 9 µM 1.76661878704098 0.0471869451963981 no 237 0.0386460462557715 291 3319099 SGTC_1622 st003707 19.4 µM 1.76274443984497 0.0475456452950548 no 238 0.0389718009585512 362 10140899 SGTC_2890 9046729 58.44 µM 1.76174032603589 0.0476389650552869 no 239 0.0390565905757503 263 903329 SGTC_1206 3978-0017 132 µM 1.76120953723914 0.0476883544407136 no 240 0.0391014722120498 290 3873677 SGTC_2967 9089538 49.85 µM 1.75489080290939 0.0482794617103668 no 241 0.0396389938132617 332 728216 SGTC_1717 st033143 58.0435 µM 1.75485667723653 0.0482826699519141 no 242 0.03964191304511 347 674616 SGTC_970 1315-0089 19.5 µM 1.74406130622876 0.0493061610781252 no 243 0.0405742001331523 277 6811083 YLR033W RSC58 SGTC_1402 3909-7673 35.9 µM 1.74376860067839 0.0493341513692467 no 244 0.0405997238718337 300 5328014 SGTC_2472 5377652 49.4 µM 1.73961392869369 0.0497328160253479 no 245 0.0409634159090883 362 1610903 SGTC_220 paclitaxel 373.376 µM 1.7353854375513 0.0501411989418115 no 246 0.0413362788498004 238 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_979 1426-2828 121 µM 1.73513159794655 0.0501657992956678 no 247 0.041358749342224 347 747872 SGTC_3223 9129970 49.47 µM 1.73453271179099 0.0502238772696647 no 248 0.0414118034193556 321 17248386 SGTC_3255 9139072 49.47 µM 1.73305852062637 0.0503670677398889 no 249 0.041542633944499 296 17646060 SGTC_225 nsc-122657 1.016 µM 1.72981533193587 0.050683228781749 no 250 0.0418316371316019 185 275685 SGTC_2087 5276107 200 µM 1.72876876477986 0.0507855896398956 no 251 0.0419252442821411 296 144405 SGTC_314 1671-0008 2.74 µM 1.72802618298281 0.0508583186017777 no 252 0.0419917651451284 371 3913060 SGTC_2347 9049783 174.81 µM 1.7261502898944 0.0510424141921489 no 253 0.0421601892122717 361 6467988 YPL169C MEX67 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.72359759888953 0.0512937805588245 no 254 0.0423902561542839 322 5393153 SGTC_2842 9000675 19.48 µM 1.71636491355461 0.0520113418134818 no 255 0.0430476370735126 309 2989072 SGTC_3323 9138564 53.9225 µM 1.71544628999524 0.0521030473059259 no 256 0.043131717343418 360 43912313 YNL103W MET4 SGTC_458 nppb 133 µM 1.71164793154246 0.0524835988040599 no 257 0.0434807847503483 267 4549 A chloride channel blocker. SGTC_1108 betulinic acid 729.144 nM 1.71046938662185 0.0526021227997105 no 258 0.0435895548578417 305 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_391 gliotoxin 8.33 µM 1.71008276733108 0.0526410505979268 no 259 0.0436252844698541 356 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_631 k072-0230 41.5 µM 1.71006373029911 0.0526429679828492 no 260 0.0436270443968731 342 5773147 SGTC_1975 st070967 30.8 µM 1.70742531408791 0.0529092423587358 no 261 0.0438715142982764 368 261391 SGTC_66 0109-0187 42.4 µM 1.70708243178747 0.0529439250435219 no 262 0.0439033660004399 331 759417 SGTC_212 3807-4682 38.772 µM 1.70055135981812 0.0536079946059556 no 263 0.0445136321734744 457 3125501 YBL034C STU1 SGTC_3320 9137005 35.139 µM 1.69573547812399 0.0541018795598568 no 264 0.0449679932355761 285 4908713 SGTC_127 0180-0333 59.125 µM 1.69094809406961 0.0545964044602384 no 265 0.0454233583118252 432 771601 SGTC_2558 carylophyllene oxide 100 µM 1.69052257869597 0.0546405315542416 no 266 0.0454640111872679 341 6708694 An oxygenated terpenoid and antifungal agent. SGTC_3210 9128157 49.47 µM 1.68672510432712 0.0550355898232673 no 267 0.0458281112855727 367 17590849 SGTC_818 4072-2707 53.5 µM 1.68625725500203 0.0550844168080657 no 268 0.0458731301460299 295 882871 SGTC_1417 3966-0327 90.4 µM 1.68355806404116 0.0553667858775984 no 269 0.0461335545120439 348 651118 SGTC_2996 9066192 71.4286 µM 1.68342848802929 0.0553803698445732 no 270 0.0461460861230938 360 6472854 SGTC_87 0100-0052 35.5 µM 1.67902717800627 0.0558433414002096 no 271 0.0465733735577782 575 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2024 5144227 134 µM 1.67450982011536 0.056321689945507 no 272 0.0470152230337125 376 3475211 SGTC_84 0443-0269 128.823 µM 1.66938563809166 0.0568681994751253 no 273 0.0475204890284061 349 6150058 SGTC_1573 oleylamine 1.06 µM 1.66914733744949 0.0568937162272799 no 274 0.0475440919203925 355 5356789 An amine of the fatty acid oleic acid. SGTC_1004 4084-0029 199 µM 1.66852379788923 0.0569605262476891 no 275 0.0476058958922264 358 716894 YLR208W SEC13 SGTC_2145 5634607 200 µM 1.66763794527875 0.0570555483708225 no 276 0.0476938104326358 284 308662 SGTC_3343 9148379 18.9835 µM 1.66495153382218 0.0573444729456578 no 277 0.0479612127878451 322 1955036 SGTC_926 2268-1401 59.4 µM 1.6645019301378 0.0573929402562187 no 278 0.0480060828331183 350 2931578 SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.6644530561409 0.0573982108183182 no 279 0.0480109624382392 368 1273210 SGTC_3013 9080133 71.4286 µM 1.6586938199078 0.0580219564770368 no 280 0.0485887526814647 386 17050193 SGTC_1921 5740136 50 µM 1.65706515648049 0.0581993092884241 no 281 0.0487531513585305 406 1774243 SGTC_3245 9134821 49.47 µM 1.65142968591952 0.0588162702813845 no 282 0.0493254336746323 367 17014901 SGTC_3307 9126885 69.2785 µM 1.64873025745227 0.0591136112038368 no 283 0.0496014542424931 383 24824909 SGTC_2829 7992743 58.44 µM 1.64733840272108 0.0592673834316769 no 284 0.0497442543073965 369 16462845 SGTC_364 0083-0097 67.7 µM 1.64417206242624 0.0596183693156976 no 285 0.0500703330052043 343 5207356 SGTC_1973 st070275 50.2 µM 1.64316892970023 0.0597299047666015 no 286 0.050173993210845 317 17118334 SGTC_134 0269-0018 6.916 µM 1.64128365408782 0.0599399654361741 no 287 0.0503692737962545 445 4378915 SGTC_2094 5332512 191.667 µM 1.63922248336528 0.060170286247654 no 288 0.0505834665040586 361 755774 SGTC_2269 7935389 174.42 µM 1.63172554258767 0.0610138619431152 no 289 0.051368658355971 351 97605 SGTC_2277 7947813 106.88 µM 1.62989703805525 0.0612210060302624 no 290 0.051561629889241 361 1246798 SGTC_2298 7976326 193.81 µM 1.62933251085118 0.0612850699965548 no 291 0.0516213236739409 288 2235818 SGTC_1874 staurosporine 7.6 µM 1.62613160011783 0.0616493083761118 no 292 0.0519608315009421 365 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2403 6032726 181.2 µM 1.62537825619557 0.061735278204478 no 293 0.052040993038802 374 2881040 SGTC_1404 3909-7820 48.3 µM 1.62395210208993 0.0618982838123501 no 294 0.0521930157305 328 23741373 SGTC_3183 9108214 49.47 µM 1.623043264709 0.0620023366134744 no 295 0.052290078253551 203 4974831 SGTC_1650 st011916 45.8 µM 1.61686494323589 0.0627133144455149 no 296 0.0529537185682086 312 242528 SGTC_2075 5212009 200 µM 1.6055857158594 0.0640276546346853 no 297 0.0541824830087105 306 780898 SGTC_1900 st060200 72.8 µM 1.60550624105651 0.0640369910414282 no 298 0.0541912204077214 361 688945 SGTC_2043 5101342 149 µM 1.60428508880434 0.0641805806277117 no 299 0.0543256131839079 382 678451 SGTC_1625 st003711 30.1 µM 1.5946188227202 0.0653260386915078 no 300 0.05539875041989 355 24207034 YER133W GLC7 SGTC_1201 1889-3372 45.9 µM 1.59152679984536 0.0656957738493649 no 301 0.0557455345199066 314 5392199 SGTC_957 1187-1561 14.1 µM 1.58398485750717 0.0666044213255894 no 302 0.0565985825201248 412 1538454 SGTC_2949 9072542 2.23 µM 1.58301604966781 0.066721844180312 no 303 0.056708903152596 433 16457352 SGTC_2378 9074213 121.43 µM 1.58230926200737 0.0668076103038451 no 304 0.056789493689861 409 657714 SGTC_3047 9092122 49.47 µM 1.5793522823709 0.0671673542968394 no 305 0.0571276379741701 376 17173831 SGTC_276 colchicine 750 µM 1.57455406127145 0.0677542872858683 no 306 0.0576797068225976 401 2833 A microtubule depolymerizer. SGTC_2064 5220758 200 µM 1.57214742293636 0.0680501625847556 no 307 0.0579581827767428 430 788518 SGTC_1473 k844-0725 134 µM 1.5691623071633 0.0684185414710153 no 308 0.0583050622807441 425 54682906 SGTC_969 1313-0238 134 µM 1.56612661087838 0.0687947382191881 no 309 0.058659489686978 442 5212874 SGTC_2881 9058953 51.95 µM 1.5638426940542 0.0690788209792285 no 310 0.0589272575584392 417 17122249 SGTC_1151 3909-8316 15.3 µM 1.56358350580761 0.0691111168908952 no 311 0.0589577054503283 399 800431 SGTC_144 4161-2749 112.381 µM 1.56017797870873 0.0695365409768929 no 312 0.059358914031216 332 797501 YMR168C CEP3 SGTC_1301 naphtanilide LB 4.81 µM 1.55762811945736 0.0698563916318646 no 313 0.059660714450953 405 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2252 omeprazole 400 µM 1.55695545471197 0.0699409581803215 no 314 0.0597405309066251 273 4594 A proton pump inhibitor. SGTC_1903 st060211 78.3 µM 1.55516536615896 0.0701663895712452 no 315 0.0599533452215681 412 688960 SGTC_2638 epoxomicin 18 µM 1.55202977914577 0.0705626100699155 no 316 0.060327549189524 411 9915668 A protesome inhibitor. SGTC_2882 9058044 58.44 µM 1.54880255891383 0.0709722031455304 no 317 0.0607145951178203 370 18076804 SGTC_2619 obliquin 87.91 µM 1.54841240379686 0.07102184442238 no 318 0.0607615183686488 523 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1149 3909-7961 23.3 µM 1.54735676832388 0.0711562915917881 no 319 0.0608886199213323 383 735261 SGTC_3177 9107506 49.47 µM 1.54448309684967 0.0715232764023698 no 320 0.0612356715228892 314 8897194 SGTC_1910 st062352 60.4 µM 1.54141972030916 0.0719160851725915 no 321 0.0616073337734494 417 2245730 SGTC_842 0271-0008 11.1 µM 1.54000553141772 0.0720979801027897 no 322 0.0617795025591155 426 1221709 SGTC_820 1582-0060 59.9 µM 1.53738726021709 0.0724356764034619 no 323 0.0620992521273235 442 3848840 SGTC_2420 aureobasidin a 50 nM 1.5362243862538 0.0725860482519994 no 324 0.0622416785093613 458 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_91 0417-1751 58.384 µM 1.53306464913613 0.0729958429733841 no 325 0.0626299633692388 504 6795624 SGTC_1087 pterostilbene 9.05 µM 1.53147293953888 0.0732029455668281 no 326 0.0628262746793356 435 5281727 Similar to reservatol, lowers cholesterol. SGTC_2329 6138490 200 µM 1.52889179265582 0.0735397423093717 no 327 0.0631456356108325 382 720019 SGTC_3336 9143619 71.43 µM 1.5224049244667 0.0743914006303919 no 328 0.0639538258467239 432 45595730 SGTC_3045 9092950 49.47 µM 1.5197561314574 0.0747413170270017 no 329 0.0642861391510323 436 44120432 SGTC_2127 5253358 187.912 µM 1.50768048275412 0.07635249086815 no 330 0.0658181615271914 375 20612 SGTC_372 0155-0182 15.9 µM 1.50103191167827 0.0772507748183698 no 331 0.0666736539564964 442 771486 SGTC_3101 9120531 49.47 µM 1.50100772912156 0.0772540566989277 no 332 0.0666767812339166 445 24824904 SGTC_1744 st037937 38.9 µM 1.49924546892038 0.0774935030473154 no 333 0.0669049816341762 412 1016152 SGTC_2178 5812956 200 µM 1.49363379074004 0.0782597426537773 no 334 0.0676356812147173 393 5403383 SGTC_2243 6634756 200 µM 1.48928027792864 0.0788581350069168 no 335 0.0682067894423245 361 885676 SGTC_1102 cgs 12066b 26.1 µM 1.48901583087432 0.0788945947440347 no 336 0.0682416000293343 381 6438352 A 5-HT1B full agonist. SGTC_3020 9089140 49.47 µM 1.48839789831104 0.078979839873244 no 337 0.0683229952658969 436 17217859 SGTC_1524 corynanthine 62.1 µM 1.48769223270324 0.0790772732703566 no 338 0.0684160384672014 413 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_3179 9107801 49.47 µM 1.48744367533691 0.0791116140114643 no 339 0.0684488344466572 411 4818259 SGTC_1199 1638-0010 4.46 µM 1.48515092890987 0.079428913081035 no 340 0.0687519237787768 470 3111136 SGTC_2025 5147754 141 µM 1.48000291186405 0.0801448684507468 no 341 0.0694362347887046 390 315777 YLR208W SEC13 SGTC_1192 1488-0095 21.4 µM 1.47960182238699 0.0802008537531482 no 342 0.0694897699409318 418 915875 SGTC_2626 ethyl orsellinate 100 µM 1.47256146533918 0.0811883877269807 no 343 0.0704346609217062 410 75653 A natural product. SGTC_2653 dihydrofissinolide 100 µM 1.46389834365806 0.082416100277363 no 344 0.0716108630157314 386 6857746 SGTC_1266 0828-0227 32.9 µM 1.46309415816478 0.0825307723402246 no 345 0.0717208080788623 419 3913820 SGTC_1833 st055984 71 µM 1.4603701525144 0.0829200918325258 no 346 0.0720941856313649 407 676288 SGTC_2341 7987486 176.74 µM 1.45933575134817 0.0830682915693307 no 347 0.0722363599856499 473 1258686 SGTC_1338 1486-1223 76 µM 1.45891304081158 0.0831289110528084 no 348 0.0722945216882801 476 3444526 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.45733407517174 0.083355639381612 no 349 0.0725120925681507 429 521171 SGTC_1649 st011737 51.3 µM 1.45661332516445 0.0834592883877878 no 350 0.0726115736661475 433 1761035 SGTC_2114 5491910 81.25 µM 1.45628374056885 0.0835067172716615 no 351 0.0726570992007102 443 2849228 SGTC_1368 1852-0141 284 µM 1.45462465976024 0.0837457750139136 no 352 0.0728866001415249 450 2838987 SGTC_1005 4092-0690 4.4 µM 1.4525363807804 0.0840474064419301 no 353 0.0731762604990516 441 1529343 SGTC_3073 9114972 49.47 µM 1.44789944844457 0.0847200811266285 no 354 0.0738225869687608 395 41905075 SGTC_3265 9137266 49.47 µM 1.44749350770038 0.0847791621557117 no 355 0.0738793767343769 374 17224265 SGTC_2172 5754775 163.918 µM 1.44395362540457 0.0852956701614049 no 356 0.0743760103072856 436 2263357 SGTC_1361 1608-0041 5.61 µM 1.44322878446154 0.0854017226549888 no 357 0.0744780167473214 463 X1361 SGTC_1505 k297-0037 20.6 µM 1.44248014752247 0.0855113604269246 no 358 0.0745834840655916 480 4089396 SGTC_3199 9111318 49.47 µM 1.43784693478843 0.0861922396597336 no 359 0.0752387444672031 439 8548020 SGTC_2797 7859098 81.82 µM 1.4374168252741 0.0862556520309597 no 360 0.0752997954088443 467 972681 SGTC_1468 k284-1086 134 µM 1.43575365137886 0.0865011872352221 no 361 0.0755362263252009 537 15996457 SGTC_2553 4-methylesculetin 85.09 µM 1.43458813582746 0.0866735640254508 no 362 0.0757022487023471 463 5319502 SGTC_1703 st026983 48.3 µM 1.43342042621033 0.0868465226383644 no 363 0.0758688622266672 479 1104023 SGTC_1902 st060212 70.5 µM 1.43264007473956 0.0869622502682668 no 364 0.0759803614991301 469 688944 SGTC_1935 st074532 41.6 µM 1.42976484471161 0.0873896466803037 no 365 0.0763922610649255 551 2829742 SGTC_2764 methyldopa 94.69 µM 1.42970994557544 0.0873978225397627 no 366 0.0764001422995602 476 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2433 5607874 27.82 µM 1.42904661936576 0.0874966535936706 no 367 0.0764954172797216 472 2252428 SGTC_830 4076-0286 57.8 µM 1.42542658296684 0.0880374842660545 no 368 0.0770169641962088 630 6866659 SGTC_1382 3002-2117 298 µM 1.4249277404604 0.0881122059344465 no 369 0.0770890449401237 468 1497314 SGTC_1676 st018489 23.4 µM 1.41849101861293 0.0890806080549581 no 370 0.0780237295058085 491 3696235 SGTC_2451 5856223 45.7 µM 1.41782233488255 0.0891816636827591 no 371 0.0781213208208543 454 2179896 SGTC_1704 st028805 70.8 µM 1.40628288141688 0.0909390392995577 no 372 0.0798200706688653 455 2876101 SGTC_523 1934-0222 13.7 µM 1.40287237432085 0.0914633213581168 no 373 0.0803274500701102 493 1361595 SGTC_1922 5578187 25 µM 1.39768626434325 0.0922648473773608 no 374 0.0811036503891248 470 1350412 SGTC_1237 0330-0133 46.1 µM 1.39489535477361 0.0926983351943727 no 375 0.0815236990630572 450 X1237 YHR072W ERG7 SGTC_2017 5132927 60.65 µM 1.39158330662719 0.0932147192041759 no 376 0.0820243084013417 492 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2639 lactacystin 53 µM 1.3910197091976 0.0933028013341042 no 377 0.0821097251118901 519 3870 A proteasome inhibitor. SGTC_1794 st048918 76.9 µM 1.39023802740309 0.0934250686652816 no 378 0.082228304764802 389 672303 SGTC_441 propafenone 146 µM 1.3839132401043 0.0944187205542041 no 379 0.0831925110730059 429 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_234 nsc-17383 10.7 µM 1.38147370716456 0.0948040572912457 no 380 0.0835666783468577 530 408974 SGTC_3232 9132874 49.47 µM 1.37914606329832 0.095172799730469 no 381 0.0839248619812971 464 3784940 SGTC_3253 9135987 49.47 µM 1.37866188585442 0.0952496350398053 no 382 0.083999513050683 429 4182430 SGTC_3282 9108498 15.4605 µM 1.37730643771067 0.095464977333871 no 383 0.0842087628546565 515 16459645 SGTC_1923 st058458 19.1 µM 1.3765748294788 0.0955813579485357 no 384 0.0843218686814657 547 3534982 SGTC_761 k216-0224 480 µM 1.37479565021828 0.0958648165968227 no 385 0.0845974035244198 525 1340404 SGTC_2391 6285546 200 µM 1.37155746047963 0.0963823105511603 no 386 0.085100622119144 521 846083 SGTC_1207 2099-0101 141 µM 1.3706641581654 0.0965254294872351 no 387 0.0852398363716973 537 5837381 SGTC_2122 5258151 111.688 µM 1.36743121044407 0.0970446958275572 no 388 0.0857450925951936 498 2173356 SGTC_427 1354-0053 47.3 µM 1.36723162531756 0.0970768196591521 no 389 0.0857763577655473 496 6813657 SGTC_2739 tacrine 100.86 µM 1.36608038872964 0.0972622670399349 no 390 0.085956866493593 455 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3289 9119912 71.43 µM 1.36389019592162 0.0976157924976445 no 391 0.086301063461391 486 17014829 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.36166834174858 0.0979753903683839 no 392 0.0866512882896381 427 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1137 ixabepilone 100 µM 1.3607708662893 0.0981209179702672 no 393 0.0867930557152148 566 154225 A novel microtubule stabilizer. SGTC_1214 0358-0031 63.7 µM 1.35610644854825 0.0988798144089459 no 394 0.0875326507094552 516 4301366 SGTC_839 0122-0028 230 µM 1.35547950695936 0.0989821437411479 no 395 0.0876324167208253 588 759448 SGTC_414 piperonyl butoxide 100 µM 1.35525529163418 0.0990187589406334 no 396 0.0876681169796324 495 5794 A potent inhibitor of cytochrome P450. SGTC_1183 1254-0324 198 µM 1.35300966216194 0.0993860252757512 no 397 0.0880262718203528 525 5799357 SGTC_2462 5162487 171.77 µM 1.35280351457307 0.099419789966826 no 398 0.088059204837425 500 2259986 SGTC_851 0394-0702 453 µM 1.35108598938006 0.0997014275629438 no 399 0.0883339444964317 551 762646 SGTC_826 1683-5028 118 µM 1.34660721178404 0.100438592828841 no 400 0.0890533851253898 496 722377 SGTC_3036 9090181 49.47 µM 1.34175356970216 0.101241938881814 no 401 0.0898379556331267 488 25236586 SGTC_1040 k898-0338 155 µM 1.33640957736184 0.102131848804995 no 402 0.0907077188083254 560 20969351 SGTC_1879 gemcitabine 100 µM 1.33564529897459 0.102259584200607 no 403 0.090832618248151 519 60750 A nucleoside analog which inhibits DNA replication. SGTC_55 0767-0285 6.563 µM 1.33550975758794 0.102282249633067 no 404 0.0908547819263237 568 3116166 SGTC_673 1082-0474 110 µM 1.33228272600323 0.102822958172304 no 405 0.0913836506240709 632 3098046 SGTC_3296 9122258 64.045 µM 1.33061555118474 0.103103115682823 no 406 0.0916577714279594 536 4730474 SGTC_2783 7738165 71.43 µM 1.330564785539 0.103111655197133 no 407 0.0916661279826996 425 17201110 SGTC_413 propylparaben 100 µM 1.33009921533551 0.103189994783178 no 408 0.0917427920225213 523 7175 A pharmaceutical preservative. SGTC_1092 toremifene 6.32 µM 1.32964341518343 0.103266732263766 no 409 0.09181789326225 574 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3240 9133527 49.47 µM 1.32872917137355 0.103420777165807 no 410 0.0919686685667161 526 17617455 SGTC_512 prima-1 270 µM 1.32632708069252 0.103826310541605 no 411 0.0923656902676914 554 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1024 4507-0395 26 µM 1.32273696754855 0.104434560297836 no 412 0.0929614326492307 527 4201836 SGTC_2913 7966556 36.57 µM 1.32163559266498 0.10462167567593 no 413 0.0931447626473712 495 2976516 SGTC_1792 st045773 43.6 µM 1.32044790488395 0.104823726972922 no 414 0.0933427591791737 518 2919270 SGTC_438 sphingosine 6.67 µM 1.31502551102944 0.10574978300764 no 415 0.0942506644271829 437 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.31182959444119 0.106298355743524 no 416 0.0947888185619538 593 6708784 An antioxidant flavonoid SGTC_1011 4112-3381 17.4 µM 1.31174752461994 0.106312469880775 no 417 0.094802667896969 555 2877139 SGTC_2659 sanguinarine 24.21 µM 1.30804116208129 0.106951291092338 no 418 0.0954296741465338 535 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2587 piperic acid 92.2 µM 1.30595186315084 0.107312616602652 no 419 0.0957844639468514 490 5370536 SGTC_3295 9122362 53.5725 µM 1.30544811148068 0.107399867456571 no 420 0.0958701524508743 508 4730473 SGTC_1636 st007707 68.9 µM 1.30459770871612 0.107547275014138 no 421 0.0960149344516167 598 403051 SGTC_2861 9024595 19.48 µM 1.30456618837419 0.10755274150434 no 422 0.0960203039127163 405 16482810 SGTC_2802 7925815 54.55 µM 1.30288431404714 0.107844714994391 no 423 0.0963071299543578 562 1262923 SGTC_2108 5365811 200 µM 1.3024292508047 0.10792381203994 no 424 0.0963848443513788 547 780283 SGTC_1969 st069479 40.1 µM 1.29890181380678 0.108538352612049 no 425 0.0969888135707093 473 3895485 SGTC_2361 9034121 116 µM 1.29761700782831 0.108762812286151 no 426 0.0972094874078795 535 6496917 SGTC_452 diindolylmethane 8 µM 1.29376185995488 0.109438321745859 no 427 0.0978738452855861 481 3071 Inhibits expression of several cancer promoting factors. SGTC_1403 3909-7815 62.9 µM 1.29345940899745 0.109491445217294 no 428 0.0979261071206023 494 6615483 SGTC_3164 9100705 49.47 µM 1.29264589187659 0.109634425905312 no 429 0.0980667798155154 474 17174235 SGTC_2150 5556613 200 µM 1.29255624909333 0.10965018937737 no 430 0.0980822898220891 589 743190 SGTC_131 0141-0277 33.849 µM 1.29250528974357 0.109659151184286 no 431 0.0980911076169533 558 1547771 SGTC_1730 st033808 45.1 µM 1.29163742809826 0.109811855707012 no 432 0.0982413679880571 614 1045166 SGTC_1061 3448-9325 110 µM 1.29100132168166 0.109923878649853 no 433 0.0983516096061543 513 723482 SGTC_491 tetrandrine 80.3 µM 1.29011683552813 0.110079779317921 no 434 0.0985050476680015 500 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2727 riluzole 51.77 µM 1.28982299055291 0.11013160789799 no 435 0.0985560617960022 493 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1748 st037455 53.6035 µM 1.28454302331072 0.111065876838599 no 436 0.0994760099882219 562 580690 SGTC_2047 4141938 200 µM 1.28085617067008 0.111721607282943 no 437 0.100122095027184 498 3807862 SGTC_2010 4012422 159 µM 1.27630053655415 0.112535675189427 no 438 0.100924650297821 578 952393 SGTC_245 methotrexate 289.6 µM 1.27460483008657 0.112839768496618 no 439 0.101224573514114 607 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3314 9135860 59.4275 µM 1.27417616659896 0.112916734100167 no 440 0.101300494876594 585 25252478 SGTC_3029 9088683 49.47 µM 1.27289683823442 0.113146657528442 no 441 0.101527325684898 550 25236615 SGTC_584 0986-0246 15.4 µM 1.27277639397307 0.113168321202778 no 442 0.101548700043896 620 53315 YDR232W HEM1 SGTC_3194 9111903 49.47 µM 1.27225948360071 0.11326132875158 no 443 0.101640469545868 556 17087251 SGTC_2785 7756463 72.73 µM 1.27077363892554 0.113528980010717 no 444 0.101904594693558 548 2201551 SGTC_3244 9134489 49.47 µM 1.26680669749269 0.114245769865991 no 445 0.102612208361491 563 16584271 SGTC_1799 st045822 46.1415 µM 1.26522124659541 0.114533145810484 no 446 0.102896014094346 552 3674992 SGTC_2686 alizarin 95.37 µM 1.26402690522838 0.114749969477173 no 447 0.103110185066395 539 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1146 3579-1023 7 µM 1.262053068933 0.11510894443468 no 448 0.103464845513632 633 X1146 SGTC_1781 st038725 66.3 µM 1.25971257337372 0.115535636343744 no 449 0.103886533984396 660 4270275 YIL048W NEO1 SGTC_2191 5911152 200 µM 1.25922358074534 0.115624925527909 no 450 0.103974793275205 560 2875902 SGTC_163 TUB2.036 7.546 µM 1.25848827797508 0.115759282764907 no 451 0.104107611930162 758 15992207 YJR013W GPI14 SGTC_104 0074-0074 590.992 µM 1.25826726468249 0.11579968879416 no 452 0.104147557868861 428 3943124 SGTC_2102 5377816 72.7585 µM 1.25548514844646 0.116309176816612 no 453 0.104651348066825 607 1379702 SGTC_1911 st060208 74.3 µM 1.25001664880365 0.117315252328963 no 454 0.105646732809738 624 688783 SGTC_157 1348-1695 65.819 µM 1.2498737525239 0.117341624266911 no 455 0.105672834472393 653 5380510 SGTC_425 3825-7017 13.1 µM 1.24929384328959 0.117448691351075 no 456 0.105778809474741 630 3397440 SGTC_177 1327-0068 8.361 µM 1.24814516935278 0.117660972102945 no 457 0.105988949638052 596 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.24500710387983 0.11824228641257 no 458 0.106564569487677 566 688662 SGTC_1424 4048-1941 275 µM 1.24437069570873 0.118360425785362 no 459 0.106681581474773 638 X1424 SGTC_981 1488-1094 54.9 µM 1.24260085088059 0.118689408832875 no 460 0.107007478108917 522 3449522 SGTC_2604 4'-hydroxychalcone 11.32 µM 1.23899812512847 0.119361087029991 no 461 0.10767309619731 556 5282362 SGTC_3033 9090887 49.47 µM 1.23769667451661 0.119604382662424 no 462 0.107914276341312 619 19325384 SGTC_2477 5967686 25.23 µM 1.23481749497393 0.120143864269622 no 463 0.108449217368369 583 776118 SGTC_3155 9099265 49.47 µM 1.23386559585399 0.120322601420071 no 464 0.108626495705555 546 25236499 SGTC_218 alverine citrate 93.75 µM 1.23260870929387 0.120558892594247 no 465 0.108860893001563 563 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_59 0330-0160 1.33 µM 1.22926290795477 0.121189485904183 no 466 0.109486624730831 746 4293482 SGTC_195 4234-0266 16.654 µM 1.22557975562616 0.121886339260148 no 467 0.110178429967271 641 2303354 SGTC_404 fumagillin 50 µM 1.22331863356862 0.122315535981646 no 468 0.110604685970695 624 12015870 A methionine aminopeptidase binder. SGTC_1036 k216-0215 33.5 µM 1.2225220664566 0.12246698940278 no 469 0.110755132204983 640 622330 SGTC_1681 tripelennamine 100 µM 1.22158945005586 0.122644477407363 no 470 0.11093146010268 525 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_791 1348-1292 225 µM 1.22005884186276 0.122936161316392 no 471 0.11122128477566 691 5437054 SGTC_613 3914-0030 117 µM 1.21918886222876 0.12310216763477 no 472 0.111386259143284 332 1145395 SGTC_2447 5741742 33.78 µM 1.21908535496817 0.123121928964186 no 473 0.111405898893469 625 1776504 SGTC_2513 baicalein 25.65 µM 1.21791914134078 0.123344733010971 no 474 0.111627350745581 611 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2972 9093619 59.92 µM 1.21512611503615 0.12387948608049 no 475 0.11215899733038 587 25236256 SGTC_3103 9120822 49.47 µM 1.21397541876288 0.124100269802411 no 476 0.112378555499214 649 17141819 SGTC_1846 st056244 14.8 µM 1.20880492803171 0.125095727427471 no 477 0.113368898940536 650 5393182 SGTC_2866 9034245 58.44 µM 1.20426792801475 0.125973803517979 no 478 0.114243019289305 568 6462273 SGTC_2254 7938975 95.19 µM 1.20234757469142 0.126346753874652 no 479 0.114614445876974 722 2969277 SGTC_1561 5-methoxyflavone 52.9 µM 1.20149122748246 0.126513312213797 no 480 0.114780353686348 545 94525 SGTC_2782 7736369 71.43 µM 1.19939637671517 0.126921402311431 no 481 0.115186927901518 660 2950836 YOL077C BRX1 SGTC_1671 st016596 74.5 µM 1.1983384947289 0.127127832203676 no 482 0.115392633082825 666 2829167 SGTC_1440 4100-1550 40 µM 1.19752907503818 0.127285936063923 no 483 0.115550200964769 578 742806 SGTC_2486 5283202 22.39 µM 1.19461031000266 0.127857193793557 no 484 0.116119659594846 589 1377751 SGTC_2085 5307070 144.047 µM 1.19455466638819 0.127868101583778 no 485 0.116130535122905 566 2840351 SGTC_2335 9018011 154.17 µM 1.19278399207103 0.128215543724923 no 486 0.116476990494173 658 6458208 SGTC_2483 5729050 27.16 µM 1.19188027570012 0.128393123637196 no 487 0.116654096611275 724 2865180 SGTC_3315 9136395 68.55 µM 1.19033029262391 0.128698092117411 no 488 0.116958299507632 661 16876844 SGTC_782 0083-0095 30.5 µM 1.19015604851661 0.128732407092647 no 489 0.116992532138097 676 3591729 An indicator and reagent. SGTC_2933 9026794 32.47 µM 1.18952420526836 0.128856893153535 no 490 0.117116725913211 646 17586027 SGTC_766 1391-0721 126 µM 1.18747477195848 0.129261248051162 no 491 0.117520200950963 625 1020919 YIL115C NUP159 SGTC_206 4546-0025 72.014 µM 1.18483092658219 0.12978417887132 no 492 0.118042151063094 720 6620745 YIL048W NEO1 SGTC_2423 st077119 87.2 µM 1.18395671086968 0.129957413375057 no 493 0.118215099634736 636 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2921 7974240 10.71 µM 1.18315305713761 0.130116806476238 no 494 0.118374246728213 628 2979074 YDR527W RBA50 SGTC_1405 3909-7894 12 µM 1.1816727052319 0.130410766897847 no 495 0.118667796294481 626 7104060 SGTC_530 4358-1714 28 µM 1.17842734753594 0.131056819261463 no 496 0.119313140263281 701 1564641 SGTC_2374 9071832 200 µM 1.17754512278369 0.131232825059704 no 497 0.119488999263517 611 17381698 SGTC_492 tmb-8 126 µM 1.1762175387698 0.131497988562588 no 498 0.119753978825952 463 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2461 5755302 26.15 µM 1.17374693913918 0.131992435041508 no 499 0.120248201463151 671 2788904 SGTC_3137 9097352 49.47 µM 1.17286898613935 0.132168450077078 no 500 0.120424174142593 690 44120435 SGTC_73 0327-0325 16.231 µM 1.17134619898122 0.132474127304829 no 501 0.120729824244554 730 53298 SGTC_149 3970-0822 46.1 µM 1.17092896010227 0.132557966857766 no 502 0.120813666637615 788 3114250 YBL034C STU1 SGTC_2195 6536160 144.242 µM 1.17010490597812 0.132723658827571 no 503 0.12097937721292 574 3834386 SGTC_1851 st056236 18.9 µM 1.16638523009694 0.133473346176608 no 504 0.121729363724915 669 5393171 SGTC_988 1497-1057 103 µM 1.16632300457844 0.133485912226617 no 505 0.121741937781424 660 3533044 SGTC_1920 st075728 45.7 µM 1.16349415487876 0.13405803998779 no 506 0.122314534136878 646 3400306 SGTC_2963 9082507 9 µM 1.16327450296658 0.134102534418302 no 507 0.122359073528166 605 16459611 SGTC_2192 5915882 198.485 µM 1.16248888285998 0.134261758878889 no 508 0.122518468928633 595 2876149 SGTC_1094 duloxetine 25.4 µM 1.15906519152478 0.134957166309726 no 509 0.123214806498687 642 60834 A selective serotonin reuptake inhibitor. SGTC_519 k048-0011 62.8 µM 1.1518653992072 0.136427610627892 no 510 0.124688194257327 638 6836379 SGTC_797 k781-0471 270 µM 1.15171315718656 0.136458821533464 no 511 0.124719481914869 686 23738129 SGTC_48 0382-0018 55 µM 1.15093407519225 0.136618616394646 no 512 0.124879678983553 626 762596 SGTC_2667 digitoxin 100 µM 1.14964674273635 0.136882937081328 no 513 0.125144698897297 565 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1722 st034304 3.6505 µM 1.1449807357298 0.137843909986764 no 514 0.126108568771117 670 4036148 YLR033W RSC58 SGTC_302 1094-0063 18.9 µM 1.14331392200723 0.138188306533989 no 515 0.1264541383745 595 5440289 SGTC_3144 9087057 49.47 µM 1.14233390609755 0.138391070773033 no 516 0.126657626374621 652 17249618 SGTC_1332 1480-0653 17.5 µM 1.14183669772029 0.138494020150248 no 517 0.126760952604144 656 5749438 SGTC_1169 aniline yellow 25.8 µM 1.13848034943113 0.139190333182847 no 518 0.127459979851103 636 6051 A DNA damaging agent. SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.13666973363451 0.139566953891382 no 519 0.127838188227837 645 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2763 lisinopril 49.32 µM 1.13643109542196 0.139616643944316 no 520 0.127888094001221 625 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3246 9135460 32.98 µM 1.1341212574306 0.140098227944435 no 521 0.128371843979805 587 41446951 SGTC_1319 1306-0155 43.7 µM 1.13345297054762 0.140237771022433 no 522 0.128512040115171 726 3122360 SGTC_2175 5807670 165.306 µM 1.13218573760769 0.140502637475432 no 523 0.128778177499061 653 241186 SGTC_3089 9117425 49.47 µM 1.13097795821065 0.140755393337078 no 524 0.1290321844133 612 9401657 SGTC_2935 9038016 29.96 µM 1.12901174355191 0.141167529004603 no 525 0.12944643986232 717 6463195 SGTC_1751 st044839 27.194 µM 1.12797781655594 0.141384577010127 no 526 0.129664643925315 674 5291326 SGTC_912 3474-0017 2.18 µM 1.12768075328981 0.1414469800751 no 527 0.129727384424128 687 3360550 SGTC_1735 st034310 56.75 µM 1.12750216100067 0.141484505329352 no 528 0.129765113676315 679 871153 SGTC_3 0833-0587 95.581 µM 1.1273200901368 0.141522768434653 no 529 0.129803585630664 670 5382644 SGTC_2922 7999257 32.47 µM 1.12590627152141 0.141820128116156 no 530 0.13010259724608 611 2988377 SGTC_1271 0832-2808 169 µM 1.12514936716044 0.141979496877174 no 531 0.13026287238282 709 3663794 SGTC_2588 indole-3-carbinol 100 µM 1.11875368516075 0.143330969211896 no 532 0.131622617637442 734 3712 Induces cell cycle arrest. SGTC_259 usnic acid 108.925 µM 1.11869455593751 0.143343504208333 no 533 0.131635234256418 714 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_210 3551-0445 56.827 µM 1.11697506678748 0.143708348086194 no 534 0.132002493022645 694 2865180 YOR207C RET1 SGTC_2620 irigenin 100 µM 1.11647561087251 0.143814440758116 no 535 0.132109302115719 699 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2681 menadione 3.18 µM 1.11401589204039 0.144337696389667 no 536 0.132636184483027 683 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3206 9114350 49.47 µM 1.11256901790062 0.144646088379436 no 537 0.132946786431909 644 17087243 SGTC_2611 pyromycin 23.93 µM 1.10805002664069 0.145612138814473 no 538 0.133920105667574 664 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1096 rimcazole 32.2 µM 1.10638170843954 0.145969878588749 no 539 0.134280669618883 667 18528119 A dopamine reuptake inhibitor. SGTC_630 4356-0227 183 µM 1.10608165009145 0.146034283119842 no 540 0.134345590164879 673 779312 SGTC_2954 9074818 52.69 µM 1.10548913271509 0.146161517127404 no 541 0.134473850363707 674 16648742 SGTC_117 lucigenin 22.078 µM 1.09994158797534 0.147356378746375 no 542 0.135678786541937 741 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_227 fluconazole 33.516 µM 1.09792277709163 0.147792821669525 no 543 0.136119105547467 754 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_150 3970-0969 77.2 µM 1.09599799763422 0.14820974135425 no 544 0.136539825377396 779 6615640 SGTC_1776 st049249 45.9 µM 1.09473763008629 0.148483171053 no 545 0.136815798869585 712 1822314 SGTC_3192 9110362 49.47 µM 1.09419662963968 0.148600641486577 no 546 0.136934374670283 740 16649480 SGTC_2670 beta-carotene 100 µM 1.0923560673954 0.149000758165321 no 547 0.137338312620951 631 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1981 st071826 47 µM 1.09200733594217 0.149076649325557 no 548 0.137414938371098 663 11838600 SGTC_2943 9068529 45.32 µM 1.08922095086079 0.149683951424367 no 549 0.138028231057849 766 3270634 SGTC_415 dibenzyl ketone 100 µM 1.08861753588328 0.149815684895488 no 550 0.138161290246756 743 7593 SGTC_1958 st076513 41.9 µM 1.08855836555791 0.14982860672218 no 551 0.138174342617183 702 732122 YGL099W LSG1 SGTC_2112 5488546 200 µM 1.08761653162887 0.150034387862898 no 552 0.138382214779935 725 600757 SGTC_835 0312-0010 67.2 µM 1.08421870231959 0.150778344600219 no 553 0.139133920626428 680 1626196 SGTC_2163 5671233 125 µM 1.08260474390266 0.151132580673752 no 554 0.139491950378497 774 701023 SGTC_2282 7944268 200 µM 1.07772379899694 0.152207230913497 no 555 0.140578517215834 744 2970414 SGTC_1485 3909-9022 254 µM 1.07730020769628 0.152300732776575 no 556 0.140673084774552 741 714516 SGTC_2544 sphondin 68.51 µM 1.07550301415248 0.15269786214558 no 557 0.141074791731094 684 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1766 st045414 44.774 µM 1.07527410554693 0.152748493799573 no 558 0.14112601295683 785 253960 SGTC_807 1315-0151 48 µM 1.07436753616406 0.152949124709637 no 559 0.141328993299495 811 4011080 SGTC_1633 st005664 67.9 µM 1.07427051467098 0.152970606671503 no 560 0.1413507280702 738 2063822 SGTC_3039 9090270 49.47 µM 1.07338167479699 0.153167501777205 no 561 0.14154995157437 685 17173750 SGTC_1014 4130-3005 69.3 µM 1.0717889169395 0.153520748204482 no 562 0.141907426123557 742 743608 SGTC_1758 st042942 75.2445 µM 1.07163390628021 0.153555155702084 no 563 0.141942248935102 740 669317 SGTC_3001 9076041 71.4286 µM 1.07131316963562 0.153626365376971 no 564 0.142014320102054 695 16004211 SGTC_967 1306-0166 352 µM 1.07129498267423 0.153630403885525 no 565 0.142018407547481 737 4437607 SGTC_15 0266-0086 27.098 µM 1.07108276319344 0.153677533511252 no 566 0.14206610889714 826 1712902 YIL048W NEO1 SGTC_2843 9000894 45.46 µM 1.06903335955836 0.154133156855578 no 567 0.14252731890368 588 2242070 SGTC_3065 9113888 49.47 µM 1.0687166795903 0.154203640759066 no 568 0.142598676675487 683 16648368 SGTC_781 4335-2806 94.4 µM 1.06861734495777 0.154225754198714 no 569 0.14262106481096 830 845254 SGTC_1889 st059080 5.18 µM 1.06715120236397 0.154552384339233 no 570 0.142951781873335 787 176925 Isolated from Daphnopsis sellowiana. SGTC_838 0109-0203 71.4 µM 1.06097746163065 0.155932795336616 no 571 0.144350072007396 765 759422 SGTC_269 exalamide 29 µM 1.06024489145922 0.156097131332021 no 572 0.144516601523758 715 3316 A derivative of salicylamide. SGTC_1482 3346-2049 8.48 µM 1.05751150464944 0.156711313523715 no 573 0.145139103432335 719 3826804 SGTC_2702 st077768 96.8 µM 1.05267204038204 0.157802619476639 no 574 0.146245663626027 669 6484119 SGTC_2283 7944793 200 µM 1.04736419241955 0.159005272185093 no 575 0.147465820014436 736 2970533 SGTC_1990 st072050 59.8 µM 1.04728390387986 0.1590235099586 no 576 0.147484328781735 765 17233948 SGTC_747 3448-8087 38.7 µM 1.04643626344298 0.159216137544667 no 577 0.147679828704635 766 5168703 SGTC_558 k064-0027 21.3 µM 1.04570288271813 0.159382922696126 no 578 0.147849115732907 777 5088526 SGTC_147 4466-0538 29.23 µM 1.04569526364302 0.159384656023313 no 579 0.147850875133495 772 6742687 YHR072W ERG7 SGTC_1739 st037196 92.5 µM 1.04532861742565 0.159468082028437 no 580 0.147935557827201 814 612214 SGTC_652 0437-0092 114 µM 1.04528715261495 0.159477518654018 no 581 0.147945136818674 734 3091274 SGTC_3153 9100258 49.47 µM 1.04485927978793 0.159574915959716 no 582 0.148044006088647 686 25236848 SGTC_2886 9058944 51.95 µM 1.04399177294388 0.159772507246892 no 583 0.148244597995651 592 4949929 SGTC_751 0833-0568 350 µM 1.04359736109557 0.159862395003042 no 584 0.148335857174903 754 6954252 SGTC_1230 0170-0365 3.77 µM 1.04286978030127 0.160028299836031 no 585 0.148504303706168 893 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_3344 9148862 3.898 µM 1.04211458095 0.160200621359673 no 586 0.148679279606376 772 4905352 SGTC_2756 carbadox 75.1 µM 1.0401194742214 0.160656448460183 no 587 0.149142198551431 739 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2663 amphotericin b 100 µM 1.03760213879753 0.161232797951718 no 588 0.149727660885462 718 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1364 1653-0028 37.6 µM 1.03544327687056 0.161728147210961 no 589 0.150230971898638 767 5718652 SGTC_864 0469-0573 172 µM 1.03217578849123 0.162479754519238 no 590 0.150994887498367 731 689425 SGTC_1026 k007-1105 30.6 µM 1.03187304632763 0.162549507966868 no 591 0.151065797094087 816 7066794 SGTC_3224 9130643 49.47 µM 1.03164459915853 0.162602156338834 no 592 0.151119319657389 725 17644395 SGTC_1109 tnp00067 928.257 nM 1.03022982803952 0.162928454268543 no 593 0.151451065368977 771 676295 SGTC_186 3455-3465 67.277 µM 1.02848911423557 0.163330510227619 no 594 0.151859904417479 697 755278 SGTC_277 nystatin 15.5 µM 1.02340935106535 0.164507474325776 no 595 0.153057169969327 794 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2950 9072895 21.46 µM 1.02322267931406 0.164550830000499 no 596 0.153101286094561 776 17332245 SGTC_2467 5474540 200 µM 1.02155854525158 0.164937662703487 no 597 0.153494943253102 777 5413519 SGTC_3056 9094900 49.47 µM 1.01934001476356 0.165454281515994 no 598 0.154020786638541 758 25236784 SGTC_2766 oltipraz 83.91 µM 1.01624857281666 0.166175914811382 no 599 0.154755515679424 754 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_3277 9138724 49.47 µM 1.01588345920428 0.166261277087394 no 600 0.154842443225197 699 15943418 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.0158267230686 0.166274544337877 no 601 0.154855954060856 783 6312947 SGTC_711 k292-0785 179 µM 1.00591415388446 0.16860300507001 no 602 0.157228433537645 790 4146315 SGTC_691 1548-0686 185 µM 1.00568956547964 0.168656002529553 no 603 0.157282462065001 793 46495133 SGTC_1983 st071813 46.9 µM 1.00545189354478 0.168712099047359 no 604 0.15733965134788 794 11838595 SGTC_1256 0570-0116 285 µM 1.00527651467364 0.168753500532855 no 605 0.157381860264247 742 410638 SGTC_2144 5628481 200 µM 1.00237335110418 0.169439795399018 no 606 0.1580816539304 771 2818399 SGTC_38 0929-0051 58.268 µM 1.00126196887739 0.169702994591732 no 607 0.158350087084931 850 1379719 SGTC_803 4488-1585 147 µM 1.00073748037506 0.169827295766057 no 608 0.158476871071972 809 747204 SGTC_595 3909-8003 73.7 µM 1.00062452223779 0.169854073923252 no 609 0.158504185020781 789 699517 SGTC_1945 st075991 56.6 µM 0.999544790081961 0.17011017471756 no 610 0.158765426475244 726 1084980 SGTC_668 1682-0499 62.6 µM 0.998506446360085 0.170356691912133 no 611 0.159016920070062 840 682214 SGTC_2405 ticlatone 3.52 µM 0.998071341599847 0.170460059814104 no 612 0.159122382833675 772 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_233 rapamycin 362 pM 0.996557499737652 0.170820016358736 no 613 0.159489671985567 842 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2977 9011197 71.43 µM 0.995145085233646 0.171156294123181 no 614 0.159832852812607 730 2704722 SGTC_756 0508-1999 28.3 µM 0.994649698344996 0.171274339596006 no 615 0.159953333576821 786 6753853 SGTC_3107 9121808 49.47 µM 0.99018884559983 0.17233965760532 no 616 0.161040911782654 773 662681 SGTC_1613 st002381 52.1 µM 0.989302222886766 0.172551898825715 no 617 0.161257648405112 829 551167 SGTC_1515 3460-0031 42.1 µM 0.987971996172538 0.172870643195109 no 618 0.161583181609377 757 2876596 SGTC_1060 3448-7350 82 µM 0.985534231981518 0.173455745085425 no 619 0.162180862622803 812 570178 SGTC_2985 9022375 71.43 µM 0.983967940798368 0.173832344018533 no 620 0.162565638070965 820 4939335 SGTC_878 0828-0289 13.7 µM 0.982940261603534 0.174079721448034 no 621 0.162818420413129 826 745350 YLR208W SEC13 SGTC_2379 9035213 200 µM 0.981624411103858 0.174396792466663 no 622 0.163142458374439 885 646551 SGTC_1 0258-0098 57.368 µM 0.980399537368859 0.174692270958716 no 623 0.163444469018456 715 6790032 YDR047W HEM12 SGTC_3018 9082602 49.47 µM 0.97990786160559 0.174810968132246 no 624 0.163565800984567 851 17332089 SGTC_2366 9070441 60.58 µM 0.979665523977133 0.174869490539621 no 625 0.163625624714134 832 6837235 SGTC_892 0929-0076 29 µM 0.979053530567107 0.175017336910925 no 626 0.163776765300446 837 5751038 SGTC_3061 glucosamine 200 µM 0.978134593046294 0.175239484241289 no 627 0.164003880285289 807 91431 and experimental redox chemotherapeutic SGTC_2057 5236571 38.335 µM 0.977478074477342 0.175398302911553 no 628 0.164166263624427 850 54684039 YBR257W POP4 SGTC_2333 9017922 200 µM 0.975768542206954 0.175812284549938 no 629 0.164589588539089 829 3163164 SGTC_2034 5197015 53.07 µM 0.975731144467951 0.175821347727179 no 630 0.164598857097318 820 780676 SGTC_545 4218-0007 221 µM 0.974738976747255 0.176061903266787 no 631 0.164844876872432 785 2840508 SGTC_2312 7706453 155.7 µM 0.973304573958997 0.17641004887439 no 632 0.165200974924151 793 976098 SGTC_1721 st082152 9.2685 µM 0.96776879913031 0.177757723365169 no 633 0.166579924739621 787 5296051 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.963805045539965 0.17872667149355 no 634 0.16757183829798 879 5106787 A p450 inhibitor. SGTC_3233 9132340 49.47 µM 0.963765961540154 0.178736242187794 no 635 0.16758163781783 816 17682950 SGTC_2698 st077697 67.5 µM 0.962530161797307 0.17903902502412 no 636 0.167891679879904 781 3154499 SGTC_518 1021-0119 62.6 µM 0.962224417383925 0.179113985118869 no 637 0.167968443124937 785 1097762 SGTC_2290 7904846 200 µM 0.960598933938575 0.179512840243122 no 638 0.168376932460964 818 2962154 SGTC_2796 7949634 45.45 µM 0.959761438032807 0.179718559643637 no 639 0.168587647110175 793 2971588 SGTC_2101 5377231 179.231 µM 0.959713476235617 0.179730345284777 no 640 0.168599719466959 848 2844213 SGTC_219 mitoxanthrone 164.414 µM 0.959590362904558 0.179760600117558 no 641 0.168630710592333 789 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2993 9054257 71.4286 µM 0.958381531088212 0.180057837823109 no 642 0.168935202396126 853 6470217 YGL055W OLE1 SGTC_531 3788-1495 174 µM 0.957530179267119 0.180267360428746 no 643 0.169149860643853 804 2896655 SGTC_333 3486-0131 40.1 µM 0.957131060054033 0.180365638632269 no 644 0.169250554084546 898 6744690 SGTC_1032 k061-1018 98.7 µM 0.95594980758256 0.180656704479761 no 645 0.169548796679439 926 4005393 SGTC_3342 9147791 14.508 µM 0.955110075406804 0.180863797218326 no 646 0.169761017159027 842 1838168 SGTC_2737 bleomycin 30.5 nM 0.954869129228261 0.180923246249532 no 647 0.169821941481533 894 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3219 9131112 49.47 µM 0.951259325193244 0.18181536451403 no 648 0.170736374729606 815 17612988 YMR079W SEC14 SGTC_899 1083-0020 478 µM 0.948588708615154 0.182477142012824 no 649 0.17141491801414 868 767123 SGTC_3187 9109394 49.47 µM 0.946504317542394 0.182994697190998 no 650 0.171945710577028 848 17098090 SGTC_2794 7785382 27.27 µM 0.946424089993683 0.183014636013447 no 651 0.171966161564701 927 2205081 SGTC_26 0302-0163 425.158 µM 0.944364060850051 0.183527075901542 no 652 0.172491820125583 881 3100915 SGTC_2862 9027634 71.43 µM 0.944180689861744 0.183572733418876 no 653 0.172538660599968 774 5012562 SGTC_426 0988-0037 14.6 µM 0.943752055988582 0.183679486517868 no 654 0.172648182915289 902 5383008 SGTC_700 3453-2283 142 µM 0.942213835585572 0.184062905267332 no 655 0.173041585895952 913 565664 SGTC_516 3992-2719 87.3 µM 0.941976489019192 0.184122110912323 no 656 0.173102338576016 823 5350887 YDR037W KRS1 SGTC_2362 9071156 126 µM 0.941423565894662 0.184260082492612 no 657 0.173243920847358 848 653133 SGTC_446 go6976 132 µM 0.932075744443957 0.186602385609728 no 658 0.175648691121229 846 3501 A protein kinase C inhibitor. SGTC_1765 st044815 90.4 µM 0.931516670234857 0.18674305586105 no 659 0.175793182753357 854 645695 SGTC_49 0717-0965 32.132 µM 0.930402937017723 0.18702348101004 no 660 0.176081249234789 906 5889349 YGL099W LSG1 SGTC_2411 st077133 39.94 µM 0.930039850451863 0.18711495828846 no 661 0.176175225929662 930 1403142 YNL221C POP1 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.929844140161782 0.187164277688941 no 662 0.17622589424966 887 2333 A French combination drug. SGTC_1999 st074831 12.5 µM 0.926563346862856 0.187992241028638 no 663 0.177076646400491 881 17112523 SGTC_2221 6807166 181.081 µM 0.925516886611625 0.188256807777407 no 664 0.177348551979484 819 674925 SGTC_2170 morpholine 200 µM 0.924463146223891 0.188523447098833 no 665 0.177622615411196 886 121171 Reacts with secondary amines. SGTC_2491 paeonol 100 µM 0.917791360676679 0.190217080857805 no 666 0.179364053047019 867 11092 Increases levels of cortical cytochrome oxidase. SGTC_3317 9138495 8.753 µM 0.915784810005755 0.190728266894585 no 667 0.179889886054522 886 17020139 SGTC_565 1418-0001 44.5 µM 0.913603121714349 0.191285026400654 no 668 0.180462712744656 935 2862145 SGTC_251 melphalan 456.522 µM 0.913570972820802 0.191293238131097 no 669 0.180471162342562 982 460612 A DNA alkylator. SGTC_3011 9081274 71.4286 µM 0.912297224115732 0.191618763183733 no 670 0.180806137606253 926 6625322 SGTC_2328 6201408 200 µM 0.912217258031775 0.191639210995332 no 671 0.180827180384478 841 2890418 SGTC_2629 bisabolol 100 µM 0.911290129475565 0.191876380937042 no 672 0.181071262888043 912 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1269 0831-0796 3.05 µM 0.909723911307623 0.192277445149512 no 673 0.181484065323704 907 927758 SGTC_1645 Cervolide 78 µM 0.909148219135209 0.192424992422709 no 674 0.181635946363422 859 23173 A fragrance. SGTC_327 1273-0057 3.96 µM 0.909096843998888 0.192438162999182 no 675 0.181649504188868 863 3108138 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.906969963120974 0.192983895731533 no 676 0.182211340705342 874 6708514 SGTC_1522 st012842 45.6 µM 0.904067500786982 0.193730156715157 no 677 0.182979804963283 810 3491067 YOR116C RPO31 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.90261749261115 0.19410363088891 no 678 0.183364469680853 946 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1075 aripiprazole 15.2 µM 0.90081098711298 0.194569540116521 no 679 0.183844412394555 957 60795 An atypical antipschotic. YIL048W NEO1 SGTC_687 k029-0044 34.9 µM 0.900799272545854 0.194572563596913 no 680 0.183847527209201 960 5829338 SGTC_775 4577-0580 57.3 µM 0.900510732375579 0.194647043623305 no 681 0.183924258229553 915 2006902 SGTC_1761 st044296 37 µM 0.899523971547826 0.194901884369732 no 682 0.184186816628588 917 1826700 SGTC_2081 5214970 32.255 µM 0.897528580743878 0.195417833388141 no 683 0.184718464780638 940 2063512 SGTC_1031 k035-0009 16 µM 0.896158363653114 0.195772610967935 no 684 0.185084094750748 977 5180959 SGTC_1500 4488-1866 171 µM 0.893447518939208 0.196475655595211 no 685 0.185808782464016 991 2900003 SGTC_2903 5923464 63.88 µM 0.892359201347948 0.196758335440044 no 686 0.186100215873864 914 2876576 SGTC_632 0781-2353 4.65 µM 0.889241974052827 0.197569366775272 no 687 0.18693652451917 951 6811515 YHR007C ERG11 SGTC_2991 9074669 71.4286 µM 0.888776724611911 0.197690587140101 no 688 0.187061543596855 951 17333109 SGTC_88 0180-0332 8.668 µM 0.887954918598268 0.197904817822887 no 689 0.187282500774944 994 3101745 SGTC_999 SEC7.066 22.7 µM 0.887759071406659 0.197955892499774 no 690 0.187335181580338 985 740511 YDR170C SEC7 SGTC_654 1124-0271 80.9 µM 0.887713238367657 0.197967846374452 no 691 0.187347511501622 925 5403748 SGTC_653 0203-0016 55.2 µM 0.881005341086508 0.199722054380332 no 692 0.189157464563985 945 295302 SGTC_732 3970-1727 52.7 µM 0.878967014735784 0.200256951945048 no 693 0.189709580429132 946 1275699 SGTC_2450 5739737 12.93 µM 0.878954180719074 0.200260322572247 no 694 0.189713059881104 886 2262825 SGTC_2669 eugenol 100 µM 0.878153846510204 0.200470583519874 no 695 0.189930117378804 902 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_467 ro 31-8220 72.8 µM 0.876719120886624 0.200847841244776 no 696 0.190319609237217 928 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1373 2887-0003 58.5 µM 0.87558559284807 0.201146200820432 no 697 0.19062768020892 898 776948 SGTC_1124 fisetin 1.16336 µM 0.8725423733676 0.201948530050122 no 698 0.191456281200289 895 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_539 4859-0462 2.54 µM 0.871990922913334 0.202094121889621 no 699 0.191606664731795 965 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3108 9121785 49.47 µM 0.871721600821207 0.202165250100831 no 700 0.191680136617617 941 17140271 SGTC_1597 7-benzyloxygramine 47.5 µM 0.870309639636362 0.202538395376025 no 701 0.192065606193844 1018 260807 SGTC_2813 7971799 71.43 µM 0.868920300478867 0.202905963810658 no 702 0.192445362533614 912 2234054 SGTC_1316 1272-0050 65.9 µM 0.868553942295875 0.203002955159419 no 703 0.192545577833382 941 7340392 SGTC_31 0508-1974 57.237 µM 0.868330699103765 0.203062071161205 no 704 0.192606660440244 926 6810525 SGTC_1068 loratadine 26.9 µM 0.868106525964449 0.203121443760004 no 705 0.192668009410322 903 3957 A H1 histamine antagonist. SGTC_1456 k015-0012 13 µM 0.867399066598823 0.203308883405959 no 706 0.19286169655442 1025 2989616 SGTC_1352 1496-0991 99 µM 0.866146235402854 0.203641071132415 no 707 0.19320498644841 953 3000039 SGTC_1226 3909-7979 35.4 µM 0.86552493505615 0.20380592866848 no 708 0.193375368017776 984 6615510 SGTC_1335 1486-0900 202 µM 0.8632707263489 0.204404734161656 no 709 0.193994317645729 986 X1335 SGTC_974 1326-0144 138 µM 0.862930506465287 0.204495200664768 no 710 0.19408783829443 966 5411856 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.862038424320348 0.204732523773143 no 711 0.194333186868539 993 165521 SGTC_1849 st056239 19.2 µM 0.861771869881653 0.204803467772146 no 712 0.194406533730375 912 5393181 SGTC_1504 k297-0033 30 µM 0.861663959890808 0.204832192389782 no 713 0.194436231740542 838 4388117 SGTC_897 1000-0139 31.4 µM 0.861598124214647 0.204849718399965 no 714 0.194454351795302 960 6151020 SGTC_2012 4023501 200 µM 0.860485909425506 0.20514593408255 no 715 0.194760623731582 888 3477460 SGTC_477 mead ethanolamide 10 µM 0.859816178129176 0.205324426045865 no 716 0.194945189918266 839 16061185 SGTC_2853 9015042 58.44 µM 0.85954983775082 0.205395434795975 no 717 0.195018618197538 938 6457456 SGTC_1293 1000-1278 195 µM 0.858918244836632 0.205563881461474 no 718 0.195192811385172 976 678847 SGTC_1082 camptothecin 424.86 nM 0.858764080138718 0.205605009839345 no 719 0.195235344327669 901 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_622 1348-1566 26.3 µM 0.858580800148708 0.205653912010421 no 720 0.195285917299009 1011 7340407 SGTC_754 3474-0146 171 µM 0.85615720490122 0.206301216811979 no 721 0.19595541514973 885 24762078 SGTC_679 0422-0091 41.4 µM 0.85439818019477 0.206771780448134 no 722 0.196442201955563 1020 627384 YHR062C RPP1 SGTC_2571 chrysanthemic acid 100 µM 0.854021794676995 0.206872551291413 no 723 0.196546456770414 898 2743 An insecticide. SGTC_1080 nisoldipine 24.4 µM 0.853935091860353 0.206895768619723 no 724 0.196570477285162 968 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2710 st078562 53.7235 µM 0.853709558318093 0.206956169339611 no 725 0.196632968380928 991 17250908 SGTC_2107 5363541 170.161 µM 0.853481310277058 0.20701730765927 no 726 0.196696223864484 988 244052 SGTC_2760 etidronate 98.04 µM 0.851170170906837 0.207636969132169 no 727 0.197337415090954 961 3305 A chelator and antioxidant. SGTC_1843 st055809 45.5 µM 0.850433520564037 0.20783470952486 no 728 0.197542053163023 916 16413835 SGTC_2988 9073640 71.4286 µM 0.849975663064474 0.207957669071109 no 729 0.197669308492918 925 9102229 SGTC_2428 5615643 7.78 µM 0.84906845494525 0.208201430428188 no 730 0.197921601080436 950 2253075 SGTC_817 1391-0715 46 µM 0.849035815194593 0.208210203673542 no 731 0.197930681746941 911 1353946 SGTC_2610 ononetin 44.17 µM 0.847515527670667 0.208619083727214 no 732 0.198353917935602 945 259632 SGTC_1860 st056228 74.6 µM 0.846504272160677 0.208891321997754 no 733 0.198635745803354 948 688679 SGTC_474 dl-dihydrosphingosine 5 µM 0.844834793458216 0.209341217029624 no 734 0.199101542682211 1011 3058739 A sphingolipid protein kinase C inhibitor. SGTC_50 0929-0078 56.389 µM 0.843365067982884 0.209737753664418 no 735 0.199512151099873 916 1377751 SGTC_1062 mesoridazine 14.2 µM 0.841655516455917 0.210199551295917 no 736 0.199990402236703 980 4078 A neuroleptic. SGTC_904 1141-0088 396 µM 0.839244963991949 0.210851722553098 no 737 0.200665930049994 963 1378119 SGTC_1564 D-Arginine 115 µM 0.83907040220123 0.210898996008063 no 738 0.200714901987905 968 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1249 0481-0015 10.2 µM 0.838186442288739 0.211138478498295 no 739 0.200963000118451 968 4227577 SGTC_2285 7945142 200 µM 0.832373769613324 0.212717213155732 no 740 0.202599001514611 955 2970608 SGTC_1120 ficusin 1.78878 µM 0.83197719200474 0.212825175078121 no 741 0.202710909302013 997 6199 A DNA cross-linker. SGTC_2019 4016004 108 µM 0.831183097863878 0.21304145064664 no 742 0.202935100827159 959 45595336 SGTC_3350 9150499 3.57 µM 0.830436695767967 0.213244853899835 no 743 0.203145962718305 1044 4910996 YPR165W RHO1 SGTC_1668 st014914 51.6 µM 0.830083656910976 0.213341100530623 no 744 0.203245743302007 1021 2839556 SGTC_2443 5493264 126.67 µM 0.826636801713895 0.214282123545253 no 745 0.204221475863437 1007 5340055 SGTC_1647 st011722 22.4 µM 0.826338540880956 0.214363664829571 no 746 0.204306038194843 967 2854783 SGTC_1356 1502-0781 85.8 µM 0.823895477619028 0.215032250856674 no 747 0.20499947514073 956 567702 SGTC_629 3448-6466 76.7 µM 0.8228872821296 0.21530851334868 no 748 0.205286047807068 1028 573744 SGTC_1684 st024538 14.6195 µM 0.822155781601805 0.215509085638356 no 749 0.205494120721074 1000 6732859 SGTC_1864 st057645 30.4 µM 0.821989803966102 0.21555461061596 no 750 0.205541349937005 1046 688666 SGTC_2848 9016370 25.97 µM 0.821783737508268 0.215611139067974 no 751 0.205599995461405 1041 7894410 SGTC_2870 9038528 12.99 µM 0.819476036183322 0.216244777980334 no 752 0.206257434405726 930 6463316 SGTC_2325 6158266 200 µM 0.819299842988245 0.216293200625978 no 753 0.206307681074963 987 3623240 SGTC_1025 k007-0731 70 µM 0.818264457759751 0.216577879230188 no 754 0.206603098154003 1013 6256118 SGTC_1331 1472-0049 76.2 µM 0.818228370723922 0.216587805248578 no 755 0.206613399056908 1006 24051409 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.816263440460127 0.217128671681898 no 756 0.207174739747484 1125 688801 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.814383874061608 0.217646770338054 no 757 0.207712536913665 1064 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2635 hydroquinidine 100 µM 0.814052945188967 0.217738064008092 no 758 0.207807310346154 1001 442912 An experimental heart treatment. SGTC_2129 girgensonine 121.053 µM 0.813862413418393 0.217790636212654 no 759 0.207861887581991 1061 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2948 9070189 9.45 µM 0.812124796731243 0.218270423352789 no 760 0.208360012983932 929 6473636 YDL196W YDL196W SGTC_1400 3771-8998 51.5 µM 0.812097164782227 0.218278057945414 no 761 0.208367939963058 988 670767 SGTC_416 estradiol valerate 100 µM 0.811798948339148 0.218360463698675 no 762 0.208453502812251 1023 13791 A steroid. SGTC_16 erodoxin 22.806 µM 0.810600127546672 0.218691913019959 no 763 0.208797671800216 1060 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1395 3486-0190 4.35 µM 0.807346216152982 0.219593010921305 no 764 0.209733522144774 1068 6748079 SGTC_3157 9099274 49.47 µM 0.807229920240166 0.219625255888932 no 765 0.209767015342643 1028 17217662 SGTC_2400 5203494 178.7 µM 0.805046616455777 0.220231117510944 no 766 0.210396389830289 984 6777674 SGTC_2983 9022671 12.99 µM 0.80353696741896 0.220650601384118 no 767 0.210832219397842 1005 6405161 SGTC_935 2996-0153 430 µM 0.80293875630311 0.220816951928088 no 768 0.211005066890146 1038 23738523 SGTC_728 3030-5151 22.5 µM 0.802032403898701 0.221069127174037 no 769 0.211267107135249 999 3125388 SGTC_464 bw-b 70c 158 µM 0.801887689979518 0.221109406309814 no 770 0.211308963770402 1062 5353454 SGTC_3052 9092717 49.47 µM 0.800983127609763 0.221361273986642 no 771 0.211570706835434 1011 25237534 SGTC_3106 9121286 49.47 µM 0.799747913359888 0.221705473697717 no 772 0.211928433317012 1017 15943471 SGTC_773 4358-1457 44.6 µM 0.798882953062177 0.221946681898147 no 773 0.212179142211196 1094 1186886 SGTC_1992 st073643 23.3 µM 0.79846864979472 0.222062270137716 no 774 0.212299289474195 1060 3161292 SGTC_1502 4534-4282 27.7 µM 0.797453400397002 0.222345664142172 no 775 0.212593878168168 1005 3278949 SGTC_2915 7971052 15.16 µM 0.797179362488553 0.222422193697274 no 776 0.212673434966295 919 5741558 SGTC_3162 9099653 49.47 µM 0.796983643971007 0.222476860480546 no 777 0.21273026525849 1024 25237511 SGTC_772 k072-0172 35.3 µM 0.795455215703324 0.222904034282708 no 778 0.213174376000953 1007 5861980 SGTC_1651 st011928 86.1 µM 0.793210955045799 0.223532118931987 no 779 0.213827462955162 1029 720198 SGTC_1163 k060-0048 49.9 µM 0.792204131488956 0.223814217973871 no 780 0.214120829985174 1103 6809982 SGTC_1242 0402-0103 60.1 µM 0.790649861709447 0.224250101479275 no 781 0.214574170804371 1005 432868 SGTC_354 2783-3500 4.88 µM 0.79034442612063 0.224335815269246 no 782 0.214663324118278 1011 6740761 SGTC_387 norethindrone acetate 66.7 µM 0.790131745082346 0.224395510513699 no 783 0.214725416103655 1005 541197 SGTC_183 3914-0051 30.55 µM 0.787304429603102 0.22518993658409 no 784 0.215551838630795 1061 1596232 SGTC_2741 miltefosine 3.04 µM 0.785407835208117 0.225723737940108 no 785 0.21610724417615 960 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2711 st079103 59.1 µM 0.781937428573306 0.226702343604989 no 786 0.217125673588815 1065 54693780 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.780710876921526 0.227048785639886 no 787 0.217486280942151 1092 4213774 SGTC_2769 toremifene 3.73 µM 0.778965907767241 0.227542169794599 no 788 0.217999898848342 1046 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_702 1488-0190 94 µM 0.777053861120858 0.228083487107098 no 789 0.218563496834296 1079 949357 SGTC_2689 tacrolimus 100 µM 0.773226140954983 0.229169321539002 no 790 0.219694279007015 1050 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_866 0495-0101 262 µM 0.77310065681096 0.229204967457659 no 791 0.219731406214417 1003 635694 SGTC_103 0844-0104 51.839 µM 0.768511037160902 0.230510862045673 no 792 0.221091818002715 1156 5375804 SGTC_1303 1160-0052 261 µM 0.767964985337655 0.230666507709615 no 793 0.221253993736923 1127 3562476 SGTC_2106 5357045 167.29 µM 0.766336224537162 0.231131115453662 no 794 0.221738134721892 1085 668842 SGTC_2856 9022925 19.48 µM 0.76601824394416 0.231221881033921 no 795 0.221832723423967 1058 4944862 SGTC_3099 9120367 49.47 µM 0.76585320779829 0.231268997411838 no 796 0.221881825298602 1094 24824940 SGTC_2032 5185112 25.99 µM 0.765123264864989 0.2314774539593 no 797 0.222099073762868 1038 5718189 SGTC_3115 9123671 49.47 µM 0.763200547447365 0.232027043211403 no 798 0.222671901179869 1198 3286988 SGTC_2177 5811945 192 µM 0.761846095954803 0.2324146351557 no 799 0.223075932490109 1111 5343475 SGTC_2350 9023895 38.85 µM 0.760353496925927 0.232842176377091 no 800 0.223521656153747 1075 2997209 SGTC_2339 9000433 200 µM 0.758094348744199 0.233490118929068 no 801 0.224197251302795 1059 2988954 SGTC_182 3448-4371 550.524 µM 0.758076309646693 0.233495296714315 no 802 0.224202650532356 1133 3491403 SGTC_3090 9117696 49.47 µM 0.757777776156705 0.233580994411466 no 803 0.224292014440162 1088 7923821 SGTC_1620 st003704 16.5 µM 0.755019620276279 0.23437358128781 no 804 0.225118604942493 1099 2834414 SGTC_2056 5235370 200 µM 0.74960988013581 0.235932443856001 no 805 0.226744849256385 1067 5511916 SGTC_502 l-744,832 89.3 µM 0.749589972213709 0.235938191026806 no 806 0.226750846075554 1106 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_321 4534-3890 65.3 µM 0.749102847774054 0.236078841865698 no 807 0.226897609371121 1141 699746 SGTC_1276 0871-0068 94.2 µM 0.748886677735317 0.236141272944894 no 808 0.226962755325394 1086 3414906 SGTC_3215 9129942 49.47 µM 0.747484850078916 0.236546349006628 no 809 0.227385472186218 1062 17682944 SGTC_720 r052-1644 49.9 µM 0.745768374345033 0.237042866958156 no 810 0.22790367372586 1064 1422863 YOR257W CDC31 SGTC_1058 3448-5425 97.3 µM 0.744408585298536 0.23743661383824 no 811 0.228314663307337 1081 7279705 SGTC_1238 0333-0287 48.8 µM 0.743989801836429 0.237557951017737 no 812 0.228441322408314 1140 7226 SGTC_2126 5251174 33.877 µM 0.743652738157586 0.237655635641865 no 813 0.228543294411223 1174 790722 SGTC_40 0327-0103 19.753 µM 0.743541109104149 0.237687991781311 no 814 0.228577071226402 1061 409036 SGTC_2936 9038235 15.59 µM 0.743196023295664 0.237788031601678 no 815 0.228681505316778 1132 4749415 SGTC_1594 piperine 70.1 µM 0.743105504273076 0.237814276743476 no 816 0.228708903726182 1099 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_164 4100-3994 89.624 µM 0.741474990548631 0.238287300850801 no 817 0.229202745131548 1160 4615967 SGTC_2463 5473429 200 µM 0.739659812016557 0.23881450324391 no 818 0.229753219543449 1072 5399405 SGTC_1689 st020265 53.493 µM 0.739417597289379 0.238884900565317 no 819 0.229826729977276 1116 5758320 YPR016C TIF6 SGTC_2770 toltrazuril 17.5 µM 0.739191865736656 0.238950517430057 no 820 0.229895249739019 1125 68591 Kills coccidiodes. SGTC_2168 5727979 200 µM 0.738509931930638 0.239148805470121 no 821 0.230102317011262 1077 695210 SGTC_3202 9113761 49.47 µM 0.737795408938148 0.239356666008482 no 822 0.230319391801875 1153 4798415 SGTC_3127 9126946 49.47 µM 0.737152610291447 0.23954374564081 no 823 0.230514774273415 1017 27243249 SGTC_646 4092-0839 27.3 µM 0.737043661131148 0.239575462031889 no 824 0.230547899197412 1160 877796 SGTC_1328 1441-0025 69.2 µM 0.73620107829911 0.23982082527697 no 825 0.230804168068199 1098 4562601 SGTC_723 4182-0001 115 µM 0.734934966379873 0.240189779388991 no 826 0.231189550927928 1095 744821 YLR208W SEC13 SGTC_3128 9127691 49.47 µM 0.734809009995466 0.240226500895606 no 827 0.231227909527372 1034 41316314 SGTC_675 1309-0189 238 µM 0.73380972671009 0.240517941781666 no 828 0.231532355801152 1126 4246530 SGTC_1465 k213-0056 144 µM 0.733726609731004 0.240542191511621 no 829 0.231557688667211 1060 24048857 YMR208W ERG12 SGTC_1736 st036774 51 µM 0.733689941104806 0.240552890161487 no 830 0.231568865231005 1173 1272247 SGTC_546 peri-Naphthalide 147 µM 0.733401317586274 0.240637109668685 no 831 0.231656847913461 1096 223824 A penicillin ester. SGTC_522 1273-0010 11.6 µM 0.727942569786871 0.242232974976766 no 832 0.233324371370856 1195 5705015 SGTC_2360 9040895 200 µM 0.72731801740474 0.242415927925945 no 833 0.233515581646413 1100 4914414 SGTC_2705 st078069 42.8 µM 0.726043577138717 0.242789487590203 no 834 0.233906028280103 1113 1530061 SGTC_102 gallobenzophenone 83.616 µM 0.724954469115156 0.243108970012756 no 835 0.234239981639369 1156 70837 SGTC_478 N-arachidonylglycine 10 µM 0.72309708308222 0.243654345594914 no 836 0.234810120619446 1078 5283389 SGTC_2847 9005661 71.43 µM 0.72235771263349 0.243871627171168 no 837 0.235037289359424 1057 2991449 SGTC_1737 st035557 69.7 µM 0.720909309861282 0.244297577620915 no 838 0.235482657247096 1022 5716916 SGTC_1234 0326-0494 15.5 µM 0.720405268817755 0.244445901463119 no 839 0.235637753466969 1156 1547813 SGTC_1609 st001574 46.4 µM 0.720068381668031 0.244545064080106 no 840 0.235741446914793 1166 3960012 SGTC_3341 9147222 25.867 µM 0.719452381961112 0.24472643940211 no 841 0.235931115913967 1122 1939759 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.719279572096968 0.244777334647808 no 842 0.235984339928775 1162 688798 SGTC_684 1140-0066 328 µM 0.717795955003244 0.245214517760616 no 843 0.236441553918863 1181 6813534 SGTC_1692 fluoroquinolonic acid 71 µM 0.716991356078596 0.245451787463012 no 844 0.236689715122139 1171 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_507 nimesulide 162 µM 0.716611064830382 0.24556397518774 no 845 0.236807057606785 1165 4495 A COX2 inhibitor. SGTC_1434 4073-0095 163 µM 0.715853817450754 0.245787448767388 no 846 0.237040808733847 1189 24133745 SGTC_1604 st002052 72.4 µM 0.715617729336205 0.245857143768221 no 847 0.237113711582839 1193 6254834 YHR062C RPP1 SGTC_1480 1070-0044 41.2 µM 0.715031495685165 0.246030250246462 no 848 0.237294790916217 1167 3124987 SGTC_2628 lathosterol 100 µM 0.713630379037021 0.246444244868165 no 849 0.237727883656648 1233 6710616 SGTC_992 3909-8734 162 µM 0.712323285987111 0.246830794202235 no 850 0.238132303823525 1184 4288319 SGTC_511 blebbistatin 171 µM 0.707147366003486 0.248364661651763 no 851 0.239737451711386 1194 3476986 A myosin inhibitor. SGTC_2207 7258803 200 µM 0.705899909535376 0.248735099800862 no 852 0.240125191916408 1138 3666799 SGTC_167 3672-0051 66.205 µM 0.704752929042041 0.249075960577067 no 853 0.240482003145071 1152 3237971 SGTC_3016 9080866 49.47 µM 0.704248327784212 0.249225997141379 no 854 0.240639069667078 1201 17066299 SGTC_3010 9080089 71.4286 µM 0.703023457532754 0.249590396075065 no 855 0.241020565489669 1186 17027233 SGTC_1770 st043884 66.3 µM 0.701040512501487 0.250180921763101 no 856 0.24163886645502 1193 670149 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.699248447776748 0.250715239618527 no 857 0.242198389079357 1209 688788 SGTC_2707 st078556 66.6 µM 0.699024432052671 0.250782074094023 no 858 0.24226838114104 1150 17250899 SGTC_2817 7995342 71.43 µM 0.698051001849829 0.251072603841223 no 859 0.242572649508808 1164 18879975 SGTC_998 3996-0085 177 µM 0.696732068869991 0.251466536166459 no 860 0.24298524278027 1223 715391 SGTC_214 4373-3496 70 µM 0.696522465474463 0.251529169528086 no 861 0.243050846594862 1266 3779166 SGTC_2567 aureobasidin a 60 nM 0.696369282915545 0.25157494851541 no 862 0.243098797296987 1230 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1767 st044992 70.3 µM 0.694601621385141 0.252103536852209 no 863 0.243652497934553 1179 9600693 SGTC_1475 4092-1048 11.7 µM 0.694039434662603 0.252271771693726 no 864 0.243828739397507 1206 2881759 SGTC_2701 st077767 14.721 µM 0.693530577082299 0.252424098767875 no 865 0.243988321863769 1211 5721188 SGTC_633 0437-0093 97.7 µM 0.692829370539028 0.252634085113377 no 866 0.244208319038171 1217 2831118 SGTC_705 1124-0212 310 µM 0.692292107880643 0.252795038348421 no 867 0.244376952647363 1205 9554485 SGTC_995 3931-2021 34.6 µM 0.692131697562345 0.252843104561528 no 868 0.244427313685789 1173 730143 SGTC_770 0389-1121 67.2 µM 0.691926296186147 0.252904659161539 no 869 0.244491807892232 1253 6753108 SGTC_1290 0986-0249 10.2 µM 0.691809563374547 0.252939645117138 no 870 0.24452846504275 1168 53329 SGTC_552 k242-0005 476 µM 0.690424814040545 0.253354862161919 no 871 0.244963538270579 1213 4088318 SGTC_1348 1493-0373 93.8 µM 0.689606583048226 0.253600376995034 no 872 0.245220813206717 1198 3010129 SGTC_841 0251-0215 91.2 µM 0.689288070037828 0.253695982405903 no 873 0.24532100196401 1231 3888614 SGTC_3330 9141424 71.43 µM 0.689169674103125 0.25373152515732 no 874 0.245358249196035 1206 27261020 SGTC_2748 diazoxide 86.69 µM 0.68854888732331 0.253917929667175 no 875 0.245553597780883 1152 3019 A potassium channel activatior. SGTC_1474 0330-0125 5.35 µM 0.688010869980573 0.254079538998506 no 876 0.245722968117774 1213 X1474 SGTC_870 0573-2213 57.6 µM 0.687858328111466 0.254125369250738 no 877 0.245771000411464 1199 3916321 SGTC_1861 st057647 17.4 µM 0.687382599197653 0.254268326875234 no 878 0.245920830018303 1236 688668 SGTC_1925 st057770 10.1 µM 0.686311053365952 0.254590483220298 no 879 0.246258490111325 1154 5989122 SGTC_1670 st016595 4.04 µM 0.685939101015259 0.254702359304773 no 880 0.246375755941399 1210 597879 SGTC_3125 9127534 49.47 µM 0.685205913108751 0.254922963432369 no 881 0.246606996522551 1100 1639235 SGTC_1194 1488-0194 225 µM 0.685117801350348 0.254949481533336 no 882 0.246634793966492 1187 1391452 SGTC_1205 4161-2785 76 µM 0.683975703762919 0.255293337613906 no 883 0.246995254022647 1179 3498106 SGTC_455 paf C-16 10 µM 0.683383151133399 0.25547183537816 no 884 0.247182381929051 1189 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_41 0478-0632 82.643 µM 0.68140035828114 0.25606959639509 no 885 0.24780909811683 1226 3750424 SGTC_973 1325-0077 65.9 µM 0.680844871357256 0.256237192131741 no 886 0.247984827026416 1255 2835149 SGTC_527 4476-4215 268 µM 0.680207466005808 0.256429573878968 no 887 0.248186552820919 1193 4418754 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.679317440365233 0.256698327367071 no 888 0.248468374132889 1187 2724278 An inhibitor of dopamine biosynthesis. SGTC_1618 st003135 44.5 µM 0.679128075129947 0.256755527294474 no 889 0.248528357499507 1180 1270615 SGTC_1663 st014140 55.4 µM 0.678948353933711 0.256809820266137 no 890 0.248585293153791 1292 4207120 SGTC_1228 0124-0032 52.5 µM 0.677593973967369 0.257219164526027 no 891 0.249014583968391 1259 X1228 SGTC_1023 4482-3888 16 µM 0.67693557760718 0.257418278977934 no 892 0.24922341485926 1227 3303168 SGTC_2762 leflunomide 42.06 µM 0.674490759476595 0.258158349344072 no 893 0.249999679274407 1225 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1399 3562-5772 25 µM 0.674413970803483 0.258181611881632 no 894 0.250024081531065 1185 23847490 SGTC_3113 9123498 49.47 µM 0.674405733042905 0.258184107512344 no 895 0.250026699439456 1266 8897275 SGTC_563 tetrahydrosecaminediol 614 µM 0.673673397971465 0.25840601848808 no 896 0.250259489016746 1269 334274 A psychoactive constituent of the cannabis plant. SGTC_859 0439-0102 54.6 µM 0.672763729820358 0.258681802186144 no 897 0.250548807961443 1246 610143 SGTC_656 4090-1979 187 µM 0.672130602849907 0.258873836902815 no 898 0.25075027783295 1245 22330961 SGTC_602 3130-1533 38.1 µM 0.671945603119828 0.258929963377374 no 899 0.250809163529966 1246 720941 SGTC_2905 7799065 20.05 µM 0.671418883234082 0.259089797701707 no 900 0.250976859363486 1175 1296806 SGTC_1728 st035614 33.7865 µM 0.669742884414661 0.259598722492901 no 901 0.251510854439596 1229 15945546 SGTC_1263 0774-1208 64.8 µM 0.669144045819691 0.259780687671232 no 902 0.251701797693969 1273 906585 SGTC_23 0213-0011 39.996 µM 0.667621620281037 0.260243593370905 no 903 0.252187576650608 1266 627608 SGTC_176 1486-1328 72.834 µM 0.666354418922335 0.260629220001185 no 904 0.252592294847095 1231 22310231 SGTC_1017 4239-0030 168 µM 0.66543313784806 0.26090976291387 no 905 0.252886747835532 1224 1149593 SGTC_1386 3228-0095 33.8 µM 0.665321221801022 0.260943853484536 no 906 0.252922529910936 1236 870181 SGTC_385 1494-0393 12.4 µM 0.664966805984011 0.261051826638869 no 907 0.253035862190666 1267 3090647 SGTC_263 alizarin 107.927 µM 0.664281351781432 0.261260716135903 no 908 0.253255127084711 1243 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1379 2144-0755 36.5 µM 0.658231269160043 0.263108172150558 no 909 0.255194767460998 1276 5392327 SGTC_1690 st023502 41.2 µM 0.658024483951822 0.263171433949909 no 910 0.255261199265677 1237 24207482 SGTC_2830 7992007 71.43 µM 0.657957642568045 0.263191884396394 no 911 0.255282674658361 1212 1952075 SGTC_3166 9102297 49.47 µM 0.657658654061751 0.263283371320444 no 912 0.255378747898322 1216 25237072 SGTC_3316 9136639 10.545 µM 0.657326722483229 0.263384957453002 no 913 0.255485428784431 1282 4903665 SGTC_2969 9091408 28.7 µM 0.655152112023355 0.264050981626883 no 914 0.256184911508884 1219 4286311 SGTC_731 3966-0296 387 µM 0.654268042913335 0.264321993149418 no 915 0.256469565405302 1285 660956 SGTC_1439 4092-1168 46 µM 0.653602765118284 0.2645260275011 no 916 0.256683881154315 1258 2886240 SGTC_2596 sinensetin 100 µM 0.652547736148779 0.264849759048285 no 917 0.257023944293373 1241 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1418 3966-3099 2.4 µM 0.651075659466591 0.265301796361351 no 918 0.257498824018625 1271 740335 SGTC_2159 5658611 73.75 µM 0.65098656390283 0.265329167907224 no 919 0.257527580128332 1282 793844 SGTC_745 0469-0705 296 µM 0.649958915605237 0.26564498106255 no 920 0.25785938010696 1356 3486736 SGTC_1001 4048-4355 44.4 µM 0.649642522601352 0.265742252180101 no 921 0.25796157953703 1251 21824233 SGTC_1583 clindamycin 39.6 µM 0.648549954527406 0.266078287504782 no 922 0.258314656023789 1203 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1876 myriocin 605 nM 0.645770788687418 0.26693402949859 no 923 0.259213904250462 1324 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_554 4483-2211 187 µM 0.645019237519512 0.267165680637423 no 924 0.259457359558592 1266 747107 SGTC_1111 tnp00062 510.699 nM 0.643205635377466 0.267725106068597 no 925 0.260045338569488 1319 676306 SGTC_2768 sulfasalazine 50.2 µM 0.643001973978272 0.267787964501956 no 926 0.260111409509994 1347 5384001 An antioxidant and salicylic acid derivative. SGTC_2131 toluylene red 5.2905 µM 0.642751753866651 0.267865203081255 no 927 0.260192596670366 1248 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1329 1447-1697 50.6 µM 0.640027504186913 0.268706856885596 no 928 0.261077359198282 1269 2840515 SGTC_3180 9109287 49.47 µM 0.638722894926638 0.269110384375192 no 929 0.26150160794902 1264 18891271 SGTC_1641 st009299 47.1 µM 0.634859226353469 0.270307233147202 no 930 0.262760115844437 1241 4046054 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.634161944497497 0.270523513298618 no 931 0.262987570141611 1304 229346 A bile salt which induces apoptosis. SGTC_2407 paclitaxel 400 µM 0.632725085646338 0.27096946501019 no 932 0.26345659263541 1423 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2469 5655019 90.81 µM 0.632143362326895 0.271150116225765 no 933 0.263646601337778 1380 2788239 SGTC_2780 5215298 71.43 µM 0.631641389807585 0.271306049490559 no 934 0.263810617151581 1288 2834131 SGTC_3138 9097216 49.47 µM 0.631345725102238 0.271397915992003 no 935 0.263907247752246 1297 25237486 SGTC_1898 st060199 18.6 µM 0.630742942201871 0.271585255725603 no 936 0.264104308112987 1295 688866 SGTC_3133 9127736 49.47 µM 0.629481464694013 0.271977520346449 no 937 0.264516949816557 1307 27243420 SGTC_2003 4023581 200 µM 0.628914711213008 0.272153847714035 no 938 0.264702447199381 1325 16641307 SGTC_1180 1193-0155 285 µM 0.628103567622045 0.272406308133925 no 939 0.264968048064201 1289 2921347 SGTC_1247 0448-0043 5.84 µM 0.6271202234328 0.272712520188245 no 940 0.265290215789898 1336 3089013 YGL099W LSG1 SGTC_3049 9092223 49.47 µM 0.626041072707239 0.273048762727061 no 941 0.265644000805681 1277 8623917 SGTC_2532 xanthone 78.9 µM 0.625329981490642 0.273270437289377 no 942 0.2658772531708 1269 7020 An insecticide. SGTC_1521 st012942 49.4 µM 0.625023155806281 0.273366114214413 no 943 0.265977930271871 1367 24207259 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.623943783180776 0.27370282488617 no 944 0.266332252548296 1299 115019 SGTC_2265 7929201 200 µM 0.623236448537962 0.273923589396282 no 945 0.266564576564659 1287 1265108 SGTC_1907 st060210 83.7 µM 0.62304630322991 0.273982950198022 no 946 0.266627047251601 1327 688793 SGTC_3274 9138298 49.47 µM 0.622452566919251 0.274168347581049 no 947 0.26682216209539 1274 17015756 SGTC_2345 9052315 157.45 µM 0.621421616227603 0.274490414670189 no 948 0.267161126541728 1316 6469265 SGTC_1835 st008666 49.2 µM 0.621120740682623 0.274584442813606 no 949 0.267260091836747 1270 690455 SGTC_2406 ethylparaben 405.7 µM 0.62064532728347 0.274733049048547 no 950 0.267416504584099 1202 8434 A possible steroid mimic. SGTC_650 1328-0195 38 µM 0.618333293919203 0.275456316670685 no 951 0.268177829698929 1300 2780821 SGTC_2751 anetholtrithion 17.25 µM 0.618002365758544 0.275559916680471 no 952 0.268286889574174 1300 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1493 4348-0038 111 µM 0.61755410002749 0.275700280812849 no 953 0.268434654503449 1365 800424 SGTC_1769 st044406 64.4 µM 0.617481218472274 0.275723105321438 no 954 0.268458682820911 1319 670903 SGTC_2479 5617353 43.85 µM 0.615909446777474 0.276215567077595 no 955 0.268977143177306 1366 2731746 SGTC_3173 9105693 49.47 µM 0.614613451045476 0.276621948146012 no 956 0.269405014576707 1349 17096658 SGTC_850 0388-0143 75.9 µM 0.614320092124004 0.276713976382522 no 957 0.269501914003667 1301 67273 SGTC_3046 9092212 49.47 µM 0.611838359977814 0.277493108503242 no 958 0.270322353591486 1339 25236637 SGTC_2805 7950783 58.44 µM 0.610732327870609 0.277840688930031 no 959 0.270688400232851 1346 1178958 YDL195W SEC31 SGTC_2680 butyl paraben 22.24 µM 0.61009496240177 0.278041083184737 no 960 0.270899451752491 1341 7184 An antifungal and steroid mimetic. SGTC_2426 5582046 32.21 µM 0.608940882557533 0.278404117095067 no 961 0.271281812304466 1359 2251934 SGTC_861 0443-0273 110 µM 0.608618054536088 0.278505709039992 no 962 0.271388817242524 1347 6149169 SGTC_2920 7982904 15.77 µM 0.608055972502543 0.278682635800006 no 963 0.271575175754809 1311 6456808 SGTC_3031 9088762 49.47 µM 0.60665432286412 0.279124071781539 no 964 0.272040170643061 1292 205253 SGTC_2113 5491891 107.031 µM 0.606086022257255 0.279303149365678 no 965 0.272228816140973 1307 789979 SGTC_2412 st077135 33.4 µM 0.605665840361113 0.279435589050495 no 966 0.272368335915437 1405 13258915 SGTC_738 1315-0003 72.4 µM 0.602053124042622 0.280575559877594 no 967 0.273569388007844 1358 6251474 SGTC_490 phenamil 164 µM 0.601948755617953 0.280608526120257 no 968 0.27360412433685 1326 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2883 9059145 45.46 µM 0.601554207497281 0.280733166653819 no 969 0.273735459184596 1318 16476510 SGTC_2401 5128683 200 µM 0.599500577044081 0.281382355033011 no 970 0.274419562695999 1276 708373 SGTC_2687 chenodiol 100 µM 0.596896867663536 0.282206473108129 no 971 0.275288119355397 1378 5702181 A cholesterol synthesis inhibitor. SGTC_272 doxorubicin 8.13 µM 0.596473966434757 0.282340438092628 no 972 0.275429320208749 1338 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_99 0109-0120 622.8 µM 0.591546543906668 0.283903578298313 no 973 0.277077139476832 1395 759414 SGTC_1284 0929-0043 16 µM 0.591244005268695 0.283999688291502 no 974 0.277178470871102 1348 1239883 SGTC_1503 4585-0012 61.3 µM 0.590812423895366 0.284136819312617 no 975 0.277323054828912 1387 2922052 SGTC_1178 0988-0033 191 µM 0.587011628841874 0.285345852434518 no 976 0.278597948341627 1377 5392207 SGTC_615 k087-0205 167 µM 0.586851084364891 0.285396975533259 no 977 0.278651862238775 1299 9642773 SGTC_2372 9071633 200 µM 0.586834418158291 0.285402282898929 no 978 0.27865745935985 1380 21321366 SGTC_792 4534-1957 155 µM 0.586410609660356 0.285537260816574 no 979 0.278799808129758 1371 1717904 SGTC_2246 7293507 91.5585 µM 0.583906524646035 0.286335401360329 no 980 0.279641601603598 1395 887656 SGTC_124 0136-0217 7.121 µM 0.583104176853971 0.286591361865281 no 981 0.279911586055484 1473 3976905 SGTC_3075 9116269 49.47 µM 0.581777374091943 0.287014869021686 no 982 0.280358323110918 1393 17015205 YNL244C SUI1 SGTC_3102 9121669 49.47 µM 0.581368291177916 0.287145505492707 no 983 0.280496131721352 1415 41905072 SGTC_2225 6654152 15.4 µM 0.578628490970195 0.288021157628438 no 984 0.281419938071808 1359 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1245 0418-0076 17.2 µM 0.57786847517799 0.288264285128354 no 985 0.281676460220092 1400 6790114 SGTC_579 4491-1009 110 µM 0.577216086644086 0.288473060059644 no 986 0.281896745670503 1457 1271041 SGTC_2910 7948405 25.97 µM 0.576116328828938 0.288825161657378 no 987 0.282268277575524 1412 2971328 SGTC_1055 3448-0672 86 µM 0.576058324867611 0.288843737985947 no 988 0.282287879631737 1366 748378 SGTC_1073 triclabendazole 3.09 µM 0.576055939349329 0.288844501983246 no 989 0.282288685815932 1412 50248 An antihelmetic and likely tubulin inhibitor. SGTC_46 0329-0187a 2.197 µM 0.571359205078945 0.290350541299842 no 990 0.283878088208883 1440 46494817 SGTC_1518 st038567 90.8 µM 0.570996439519036 0.290467017315336 no 991 0.284001028179922 1351 77966 SGTC_1318 1280-3875 124 µM 0.569930961315563 0.290809245243409 no 992 0.284362262203425 1379 373245 SGTC_1578 josamycin 24.2 µM 0.569209875437187 0.291040962450129 no 993 0.28460685981576 1321 5282165 A P450 substrate. SGTC_3327 9140648 26.9345 µM 0.569148492711906 0.291060691453376 no 994 0.284627685924829 1393 8029710 SGTC_2600 tangeritin 87.95 µM 0.568002945837927 0.291428995892712 no 995 0.285016483826906 1331 68077 A bioactive flavone. SGTC_3217 9129673 49.47 µM 0.567171327731727 0.291696505320234 no 996 0.28529889305905 1369 17248312 SGTC_481 bay k-8644 50 µM 0.566185165636679 0.29201387568315 no 997 0.285633956556787 1331 2303 A calcium channel antagonist. SGTC_793 0488-0545 106 µM 0.5634220167628 0.292903977721702 no 998 0.286573774243881 1350 292548 SGTC_2448 5185112 27.17 µM 0.562811402472138 0.2931008466203 no 999 0.286781657515115 1361 5718189 SGTC_567 1080-0542 68.4 µM 0.562076603793687 0.293337835286667 no 1000 0.287031914011618 1362 5950415 SGTC_1429 4049-0205 9.46 µM 0.562075029131462 0.293338343245059 no 1001 0.287032450418469 1403 22774478 SGTC_559 1550-0661 158 µM 0.561256535683391 0.29360243001619 no 1002 0.287311333495182 1450 5830875 SGTC_2439 5492030 7.2 µM 0.558464658463035 0.294504055744009 no 1003 0.288263565575702 1381 5722370 SGTC_1309 pyrazolanthrone 13.4 µM 0.55602152022219 0.295294104387828 no 1004 0.289098071649276 1469 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1531 st059297 52.4 µM 0.555341259158933 0.29551425695681 no 1005 0.289330631401563 1414 7566702 SGTC_626 0214-0009 33 µM 0.555290041192246 0.295530835658247 no 1006 0.289348144763229 1492 3437874 SGTC_2397 5161689 200 µM 0.554543868798813 0.295772412071477 no 1007 0.289603345822235 1488 2259942 SGTC_261 5-fluorouridine 15.376 µM 0.553030390996157 0.296262685223998 no 1008 0.290121299995696 1451 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_291 SEC14.278 35.5 µM 0.551411447139608 0.296787535045462 no 1009 0.290675827659055 1465 1068044 SGTC_672 1441-0018 53.7 µM 0.55128743352571 0.296827756902049 no 1010 0.290718325773662 1363 251141 SGTC_2084 5306078 60.6385 µM 0.551263739771347 0.296835441880846 no 1011 0.290726445695798 1411 679340 SGTC_953 1188-0045 9.7 µM 0.551173889974197 0.296864585147025 no 1012 0.290757238459918 1463 6144426 SGTC_1948 st076329 66.6 µM 0.550735295726558 0.297006864349183 no 1013 0.290907572642533 1330 24208413 SGTC_1363 1636-0063 10.4 µM 0.549433469922322 0.29742935792195 no 1014 0.291354005059169 1424 6072185 SGTC_2063 5246145 200 µM 0.548860514291872 0.297615391459801 no 1015 0.291550588804954 1454 711240 SGTC_1420 4'-methoxyflavone 42 µM 0.548109239513853 0.297859404058154 no 1016 0.291808448362974 1422 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2376 9072922 81.32 µM 0.547458910208432 0.298070703398407 no 1017 0.292031746232167 1446 17087968 SGTC_1378 2093-0007 380 nM 0.547266498078262 0.298133233364698 no 1018 0.292097828343749 1442 3618014 SGTC_1996 st072960 66.8 µM 0.547238150452203 0.298142446262422 no 1019 0.292107564653823 1402 1719405 SGTC_274 sirtinol 40.1 µM 0.546312313917834 0.298443411757467 no 1020 0.292425636584658 1368 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2654 protoveratrine a 100 µM 0.545369099791518 0.298750168343916 no 1021 0.292749844079911 1401 5702278 A heart drug and vasodilator. SGTC_247 mechlorethamine 29.705 µM 0.545323292875983 0.298765069535358 no 1022 0.292765593370208 1391 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1723 st034307 2.5525 µM 0.545196777604591 0.298806227265413 no 1023 0.292809093774697 1434 867466 SGTC_2165 5727197 32.143 µM 0.544500523247993 0.299032777626766 no 1024 0.293048544217279 1518 1361712 SGTC_1218 1348-1416 30.7 µM 0.543622153243033 0.299318696801665 no 1025 0.293350755987367 1415 6787668 SGTC_2840 9008771 71.43 µM 0.540809642712297 0.300235033244397 no 1026 0.294319397884961 1467 2992978 SGTC_1455 4262-0120 131 µM 0.540497200760585 0.300336907332741 no 1027 0.294427095463455 1499 1529587 SGTC_3326 9140064 16.379 µM 0.54029275391981 0.300403577243169 no 1028 0.294497577374373 1385 1868434 SGTC_1802 st050112 57.9 µM 0.539053072080213 0.300807979363659 no 1029 0.294925117454901 1406 4662563 SGTC_1697 st025554 27.742 µM 0.537770622275954 0.301226591268964 no 1030 0.29536770805826 1405 1269519 SGTC_229 benomyl 22.8748 µM 0.53722748953601 0.301403957450592 no 1031 0.295555242513008 1405 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_328 k915-0120 63.5 µM 0.536103657776261 0.301771106697339 no 1032 0.295943456150298 1487 6624543 SGTC_920 mycophenolic acid 780.421 nM 0.534455092163014 0.302310046857612 no 1033 0.296513355773043 1432 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_72 0744-0168 198.391 µM 0.533372677759209 0.302664138588003 no 1034 0.296887813454954 1468 677577 SGTC_396 dithiazanine 1.25 µM 0.532958406510824 0.302799708870515 no 1035 0.297031186460219 1383 10578 An antihelmenthic. SGTC_3263 9137018 49.47 µM 0.531508354550656 0.303274452458352 no 1036 0.29753327671187 1366 43844957 SGTC_1783 st039459 87.517 µM 0.530891085605836 0.303476645770535 no 1037 0.297747127753209 1571 729761 SGTC_417 st075190 100 µM 0.529340693901906 0.303984759173862 no 1038 0.298284565458795 1524 222757 SGTC_202 3594-0513 34.79 µM 0.529013018196373 0.304092197613595 no 1039 0.298398209578405 1432 708429 SGTC_3309 9129340 25.759 µM 0.52809260494336 0.30439407356005 no 1040 0.298717531630527 1509 17158987 SGTC_3168 9103419 49.47 µM 0.526902022083033 0.304784757136489 no 1041 0.299130814792844 1420 16649256 SGTC_903 1134-0042 114 µM 0.52266303256158 0.306177565248478 no 1042 0.300604384006268 1442 701009 SGTC_918 glabranin 770.725 nM 0.522621210496741 0.306191320768381 no 1043 0.300618938621484 1509 124049 Also referred to as licorice root. SGTC_2307 7538926 6.34 µM 0.521704950257945 0.306492752618364 no 1044 0.3009378887418 1445 96582 SGTC_2877 9040724 71.43 µM 0.519739584436786 0.30713976144151 no 1045 0.301622546564904 1534 6463895 SGTC_716 1683-5115 658 µM 0.518780980926172 0.307455556945936 no 1046 0.301956741134543 1453 723597 SGTC_2117 5521686 200 µM 0.518468858492169 0.307558411158625 no 1047 0.302065591167197 1418 803312 SGTC_2828 7998861 71.43 µM 0.517931076598833 0.30773566279083 no 1048 0.302253179328785 1485 2988188 SGTC_2 0422-0095 29 µM 0.517714210824041 0.307807153935912 no 1049 0.302328840865743 1339 6790840 SGTC_718 1130-0073 349 µM 0.517647911287157 0.307829011445163 no 1050 0.302351973573544 1523 6740020 SGTC_3182 9108849 49.47 µM 0.516113817792757 0.308334958879989 no 1051 0.302887458857757 1458 17133045 SGTC_1526 st051518 75 µM 0.515601582813971 0.308503976284711 no 1052 0.30306635230074 1462 673993 SGTC_1259 0671-0132 43 µM 0.515128767629852 0.308660022732192 no 1053 0.303231520675871 1447 X1259 SGTC_2208 7283366 200 µM 0.514053706653166 0.309014961090974 no 1054 0.303607221077716 1530 898663 SGTC_297 0986-0032 24 µM 0.512362138029142 0.309573804541335 no 1055 0.304198792101668 1431 2847425 SGTC_1487 3970-0795 2.82 µM 0.511751325563932 0.309775706962944 no 1056 0.304412529978189 1493 3765103 SGTC_1932 st074806 40.9 µM 0.509841049911756 0.310407513709271 no 1057 0.305081412079152 1546 17251235 SGTC_1324 1418-0026 34.4 µM 0.509694030526692 0.310456162292224 no 1058 0.305132917880192 1490 1372513 SGTC_2351 9026858 72.31 µM 0.5084958958935 0.310852747527581 no 1059 0.305552808284747 1392 1409300 SGTC_550 4123-0385 25.7 µM 0.506971070342975 0.311357786059887 no 1060 0.306087558654467 1439 5731123 SGTC_788 1182-0090 188 µM 0.50604221978003 0.311665605480794 no 1061 0.306413505662865 1630 5715185 SGTC_2914 7968218 45.32 µM 0.505280116540432 0.311918263470466 no 1062 0.306681053096292 1534 2977111 SGTC_1035 k081-0041 55.2 µM 0.505056795127353 0.311992317380882 no 1063 0.306759472855701 1467 731709 SGTC_1791 st048313 56.1 µM 0.504794234748233 0.31207939274531 no 1064 0.306851682769352 1549 1204976 SGTC_2238 6671620 73.2395 µM 0.503457702054005 0.312522802327042 no 1065 0.307321255836034 1410 729941 SGTC_1897 st060201 15 µM 0.502347283135473 0.312891402712948 no 1066 0.307711627237367 1439 611878 SGTC_1596 piperlongumine 63 µM 0.500670697550035 0.313448295017774 no 1067 0.308301448979991 1579 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2981 9013952 38.96 µM 0.499826280945816 0.313728936469319 no 1068 0.308598701837517 1369 2996344 SGTC_166 k072-0058 166.424 µM 0.499292443804702 0.313906412625302 no 1069 0.308786688777619 1490 5846229 SGTC_429 1112-0049 25.5 µM 0.497572870924137 0.314478383644762 no 1070 0.309392564587544 1437 2836170 SGTC_3228 9131799 49.47 µM 0.496162513802944 0.314947834819455 no 1071 0.309889878221481 1521 17015818 SGTC_1719 st032227 49.2 µM 0.494370166801623 0.315544866654821 no 1072 0.310522389597205 1456 3125804 SGTC_2852 9023854 51.95 µM 0.49429877196138 0.315568658305825 no 1073 0.310547596144752 1548 19798528 SGTC_2820 7989630 71.43 µM 0.492008976439321 0.316332115862661 no 1074 0.31135649891969 1464 2984098 SGTC_863 0466-0191 129 µM 0.489919176905567 0.3170295753325 no 1075 0.312095546194252 1517 765160 YPR165W RHO1 SGTC_433 pimozide 108 µM 0.489860732099546 0.317049090338116 no 1076 0.312116225804548 1429 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_3071 9117417 49.47 µM 0.48826011179249 0.317583742911323 no 1077 0.312682805563141 1541 45595590 YGL055W OLE1 SGTC_2053 5265679 138 µM 0.487389887169171 0.31787458244547 no 1078 0.312991029378938 1449 764595 SGTC_2765 myclobutanil 7.74 µM 0.486087249318353 0.318310149673648 no 1079 0.31345265342169 1491 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1278 0874-0585 172 µM 0.485846677503874 0.318390617958222 no 1080 0.313537938385954 1522 766306 SGTC_1490 4089-0339 670 nM 0.485806777317706 0.318403964903583 no 1081 0.313552084340027 1543 742542 SGTC_3094 9117742 49.47 µM 0.485593825699477 0.318475202983228 no 1082 0.31362758746678 1438 17149698 SGTC_1305 1181-0477 144 µM 0.485482385316099 0.318512485482852 no 1083 0.313667102358646 1593 6252086 SGTC_2050 5263056 171 µM 0.483486338017772 0.319180576190084 no 1084 0.314375228996377 1557 763468 YGL055W OLE1 SGTC_1317 1273-0028 910 nM 0.48250123705296 0.319510512962655 no 1085 0.314724959921923 1487 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1654 st012436 41.8 µM 0.480016024200141 0.320343512179278 no 1086 0.315607999413739 1516 4323132 SGTC_3067 9117431 49.47 µM 0.479866766375471 0.32039356963406 no 1087 0.315661066918196 1513 17150885 SGTC_2926 9010726 65.15 µM 0.479483654468856 0.320522071034218 no 1088 0.315797296891691 1458 2994293 SGTC_3312 9133330 71.43 µM 0.479017090777324 0.320678592454631 no 1089 0.315963235110223 1588 17617324 SGTC_1954 st077032 68.9 µM 0.478615289281227 0.320813413200982 no 1090 0.316106169707731 1422 698907 SGTC_3208 9114115 49.47 µM 0.477768221553443 0.321097716299696 no 1091 0.316407590846706 1443 650895 SGTC_2819 7996655 46.38 µM 0.477324593082672 0.321246654110445 no 1092 0.316565500587577 1565 6456960 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.474464954821365 0.322207399480356 no 1093 0.317584191536929 1480 23665772 A membrane-active detergent. SGTC_1565 sinapyl alcohol 95.1 µM 0.470960285933479 0.323386475583441 no 1094 0.318834547781244 1450 5280507 A phenol propionate derived from cinnamic acid. SGTC_852 0418-0143 439 µM 0.470537035695081 0.323528990119716 no 1095 0.318985690250111 1547 5369229 SGTC_279 1273-0055 2.93 µM 0.46885739131744 0.324094805974902 no 1096 0.319585787070195 1578 2847562 SGTC_2860 9025725 38.96 µM 0.468223280375148 0.324308522475552 no 1097 0.319812462769262 1481 40546248 SGTC_67 0335-0847 266 µM 0.467492793126589 0.324554792758618 no 1098 0.320073673545556 1755 4552207 YOR254C SEC63 SGTC_485 niflumic acid 177 µM 0.466988496738534 0.32472485175163 no 1099 0.3202540540828 1561 4488 A COX2 inhibitor. SGTC_1344 1488-0097 29.1 µM 0.46308268196042 0.326043207140348 no 1100 0.321652551421133 1547 747966 SGTC_2267 7931562 200 µM 0.460870640714653 0.326790818947844 no 1101 0.322445708352184 1437 934880 SGTC_1441 4106-0040 13 µM 0.460500976297026 0.326915823753136 no 1102 0.322578335444094 1518 2904180 SGTC_123 0083-0120 66.675 µM 0.459138944471342 0.32737657262429 no 1103 0.32306719588957 1463 16001701 SGTC_1962 st076595 64.5 µM 0.458713670755704 0.327520488381794 no 1104 0.323219897808888 1544 279619 SGTC_3086 9117350 49.47 µM 0.458166838610429 0.327705578076029 no 1105 0.323416291174332 1482 2679265 SGTC_694 1315-0438 43.2 µM 0.45744190056245 0.327951017658097 no 1106 0.323676726674189 1597 6793154 SGTC_1732 st034308 51.822 µM 0.457049087079331 0.328084042114676 no 1107 0.323817881824529 1517 830119 SGTC_1158 4092-0494 91.8 µM 0.457046081839701 0.328085059909161 no 1108 0.323818961836936 1621 1148199 SGTC_596 1155-0152 116 µM 0.457034312864092 0.3280890457595 no 1109 0.323823191344111 1520 280313 SGTC_1796 st049173 110.4 µM 0.457014507790002 0.328095753274578 no 1110 0.323830308897085 1573 94134 SGTC_1390 3413-2614 145 µM 0.456680957805981 0.328208727174955 no 1111 0.323950189859299 1551 3421432 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.456583847656126 0.328241621488361 no 1112 0.323985095582022 1527 3256 An antibiotic and ribosome inhibitor. SGTC_529 4076-0302 30.3 µM 0.456433680489037 0.328292490532302 no 1113 0.324039075412171 1527 5816522 SGTC_2396 5342950 42.78 µM 0.455322007101037 0.328669168245456 no 1114 0.324438798024598 1543 1886677 SGTC_3024 9090631 49.47 µM 0.455046226387602 0.328762640335257 no 1115 0.324537991397595 1589 25236383 SGTC_108 0509-0257 621.132 µM 0.454875589321601 0.328820480793379 no 1116 0.324599372722357 1524 536624 SGTC_643 k048-0106 28.4 µM 0.454846710156466 0.328830270304015 no 1117 0.324609761566372 1602 6763920 SGTC_1449 4112-4002 201 µM 0.454484522135008 0.32895305541248 no 1118 0.324740064829171 1481 2059539 SGTC_1372 2752-0194 270 µM 0.453899949383151 0.329151269950339 no 1119 0.324950420002508 1487 823334 SGTC_2316 5844804 197.44 µM 0.453275301988068 0.329363125927343 no 1120 0.325175257500351 1654 776813 SGTC_2204 7233102 200 µM 0.453129088791583 0.329412723644008 no 1121 0.325227895124793 1571 2172480 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.452386664157103 0.329664611551367 no 1122 0.325495226224599 1691 551469 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.450951129113297 0.330151875280161 no 1123 0.326012386022645 1489 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_828 2074-0507 139 µM 0.447950573184926 0.331171284212797 no 1124 0.327094434209691 1637 X828 SGTC_1471 k673-0312 37 µM 0.447579998372258 0.331297270357888 no 1125 0.327228170507539 1562 24099884 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.445637807294113 0.33195787866732 no 1126 0.327929447972222 1563 1241132 A phosphatase inhibitor. SGTC_2531 methyl deoxycholate 70.07 µM 0.440999288041159 0.333537716065849 no 1127 0.329606756208132 1522 16667744 Haematoxylin. SGTC_1359 1582-0056 520 nM 0.440565040630633 0.333685768558708 no 1128 0.329763958183249 1609 3661189 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.439389067764055 0.334086835228435 no 1129 0.330189823258685 1536 390807 SGTC_1336 1486-0901 104 µM 0.436462443748012 0.335085785170573 no 1130 0.331250621030898 1598 5006114 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.43579776221304 0.335312825100453 no 1131 0.331491733800979 1616 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2381 9035592 200 µM 0.435503933817566 0.335413209306863 no 1132 0.331598342119251 1496 4749657 SGTC_580 1123-0028 41 µM 0.434860274192109 0.33563315171581 no 1133 0.331831925656756 1595 1677248 YPR107C YTH1 SGTC_2248 tofa 1.1 µM 0.429283758743357 0.337541031918472 no 1134 0.333858367379399 1602 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2459 5811157 9.22 µM 0.427988498482651 0.337984776790253 no 1135 0.33432974705369 1550 2870684 YBR192W RIM2 SGTC_3100 9120536 49.47 µM 0.427577082363959 0.33812577152621 no 1136 0.334479527055019 1598 16421196 SGTC_3291 9121177 71.43 µM 0.427529728384287 0.338142001472552 no 1137 0.3344967684189 1551 17015612 SGTC_2946 9065502 71.43 µM 0.426659145649198 0.338440435692163 no 1138 0.334813805711676 1519 16489101 SGTC_1275 0867-0008 21.1 µM 0.42658222190434 0.338466809898779 no 1139 0.334841824448742 1608 3422836 SGTC_2432 5630864 12.22 µM 0.425269918705019 0.338916870386695 no 1140 0.335319959840731 1557 5714970 SGTC_2458 5808907 16.39 µM 0.424649832142687 0.339129612025016 no 1141 0.335545980202326 1648 2731747 SGTC_2995 9067767 71.4286 µM 0.423990712322303 0.339355801589102 no 1142 0.335786293371606 1614 11673567 SGTC_466 geldanamycin 89.2 µM 0.423888959517611 0.339390725169286 no 1143 0.335823398135295 1652 5288382 HSP90 inhibitor. SGTC_2749 bexarotene 57.39 µM 0.422484674255958 0.339872844493535 no 1144 0.336335642404783 1528 82146 An retinoic acid receptor inhibitor. SGTC_2370 9071495 200 µM 0.422018385641182 0.340032988724247 no 1145 0.336505798814209 1553 21791103 SGTC_2502 avocadyne acetate 18.59 µM 0.421684556245209 0.340147658306165 no 1146 0.336627639239992 1548 3952079 SGTC_2255 7941087 197.44 µM 0.421119105723491 0.340341922909193 no 1147 0.336834055436346 1730 935561 SGTC_2035 5154463 94.595 µM 0.420922855235922 0.340409356087872 no 1148 0.336905707644582 1670 2769623 SGTC_2089 5281248 129.67 µM 0.419477412149093 0.3409061785419 no 1149 0.337433629624226 1564 2737878 SGTC_1675 st018485 24.5 µM 0.419291921788823 0.340969954617986 no 1150 0.337501399828317 1600 3323024 SGTC_2717 st081029 62.2815 µM 0.418040601593722 0.341400307450499 no 1151 0.337958716059107 1652 5292846 SGTC_138 0850-0259 40.9225 µM 0.417938352853458 0.341435481863689 no 1152 0.337996095182091 1591 6813004 SGTC_2676 harmalol 100 µM 0.417720941014658 0.341510277913894 no 1153 0.338075579845324 1657 5459187 A monoamine oxidase inhibitor SGTC_708 3448-5400 146 µM 0.41720486948163 0.341687846579462 no 1154 0.338264281874313 1585 3462195 SGTC_1557 sumaresinolic acid 42.3 µM 0.416512048503193 0.341926285861283 no 1155 0.338517676383806 1544 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_125 0133-0007 11.75 µM 0.41581334454775 0.342166813681869 no 1156 0.338773296617691 1782 26541 SGTC_2262 9014885 67.46 µM 0.415322881137866 0.342335693265887 no 1157 0.338952776604737 1687 6457424 SGTC_337 1315-0038 354 µM 0.414576854053412 0.342592630663629 no 1158 0.339225847556251 1597 1626437 SGTC_804 1595-0054 20.9 µM 0.411051689821132 0.343807707680529 no 1159 0.34051731645477 1603 761523 Stimulates phospholipase C. SGTC_810 3825-7150 143 µM 0.410405604100091 0.344030580303076 no 1160 0.340754217999492 1782 22330411 YGL099W LSG1 SGTC_812 4251-0442 148 µM 0.408231823977083 0.344780841309798 no 1161 0.34155174311045 1644 5723007 SGTC_2825 7998094 58.44 µM 0.40784436104711 0.344914634942926 no 1162 0.341693971493754 1625 2987815 SGTC_307 1501-1223 22.3 µM 0.407430547120013 0.345057549175224 no 1163 0.341845897520341 1618 2830329 SGTC_2288 7946289 167.31 µM 0.407360086761855 0.345081885474374 no 1164 0.341871768613483 1742 1246052 SGTC_1142 3253-1408 9.78 µM 0.403547519571181 0.346399660823349 no 1165 0.343272742086729 1667 256655 SGTC_2789 5281112 71.43 µM 0.400077310955874 0.347600722309132 no 1166 0.344549787513362 1560 765948 SGTC_13 0199-0087 65 µM 0.399270010370818 0.347880354237294 no 1167 0.34484713100189 1666 4589825 SGTC_719 2810-4230 27.3 µM 0.39805646411104 0.348300856783327 no 1168 0.345294282461132 1659 721079 SGTC_1866 st057638 64 µM 0.397988929562398 0.348324263476321 no 1169 0.345319173048925 1633 688802 SGTC_1971 st069429 63.5 µM 0.397473866598158 0.348502797336386 no 1170 0.345509027072298 1725 1246522 YGL099W LSG1 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.397319672877781 0.34855625131254 no 1171 0.345565870983186 1606 279621 SGTC_3023 9089636 49.47 µM 0.395665292281372 0.349129960592124 no 1172 0.346175981540401 1700 17249241 SGTC_1426 4048-4480 71.7 µM 0.394784276992043 0.34943562162665 no 1173 0.346501049772304 1706 14224343 SGTC_956 1185-0240 191 µM 0.394773203077952 0.349439464252281 no 1174 0.346505136434716 1649 1416193 SGTC_590 k048-0076 22.4 µM 0.394574889259013 0.349508281355514 no 1175 0.346578324208645 1713 6832814 SGTC_199 4063-0024 41.6 µM 0.394041184113205 0.349693507546431 no 1176 0.346775316691109 1714 306215 SGTC_2602 kawain 100 µM 0.394008940765331 0.349704698977786 no 1177 0.346787219154024 1611 5369129 SGTC_644 1498-1197 63.3 µM 0.387736328204855 0.351884350570352 no 1178 0.349105584427563 1707 6741615 SGTC_3124 9127567 49.47 µM 0.386496727559148 0.352315675088117 no 1179 0.349564412860667 1750 17592030 SGTC_938 3126-1755 342 µM 0.383499928490784 0.353359208600952 no 1180 0.350674561630922 1721 1777771 SGTC_2916 7875993 68.79 µM 0.38275043807433 0.353620365977971 no 1181 0.350952406386537 1804 1299250 SGTC_2030 5175110 200 µM 0.382176093155835 0.353820541150829 no 1182 0.351165376639699 1707 2831986 SGTC_976 1348-1067 47.6 µM 0.382022452379307 0.353874096087831 no 1183 0.351222355412786 1645 5310671 YGL099W LSG1 SGTC_934 2950-0684 338 µM 0.381113215440304 0.354191090163368 no 1184 0.351559620810461 1763 1121253 SGTC_2730 imipramine 71.33 µM 0.379466155197408 0.354765574326602 no 1185 0.352170866234538 1724 3696 A tricyclic antidepressant. SGTC_2720 fluspirilene 36.88 µM 0.379042039490969 0.354913556745564 no 1186 0.352328323003176 1702 3396 An atypical antipsychotic. SGTC_1225 1216-0074 20.6 µM 0.378032097654715 0.355266033669385 no 1187 0.35270337485748 1632 4241466 SGTC_250 brefeldin a 552.239 µM 0.376943279934613 0.355646177588234 no 1188 0.353107878472286 1632 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1820 st053765 18.6 µM 0.376479473480073 0.355808152102214 no 1189 0.353280236362105 1625 3690829 SGTC_1865 st057639 52.2 µM 0.375271218514537 0.356230231573647 no 1190 0.353729384470932 1662 688818 SGTC_677 0929-0063 136 µM 0.375133439843689 0.356278372971642 no 1191 0.3537806142833 1631 1539583 SGTC_2726 cimetidine 79.27 µM 0.374085312684136 0.356644675189977 no 1192 0.354170422758015 1687 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1899 st063254 59.6 µM 0.373981396352656 0.356680999352574 no 1193 0.354209078567028 1603 3093813 SGTC_3338 9144300 39.5675 µM 0.373424635381401 0.356875638399825 no 1194 0.354416213513354 1716 4901274 SGTC_1915 st067105 30.6 µM 0.37248706562599 0.357203489251416 no 1195 0.35476512021743 1595 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1285 0929-0069 65.5 µM 0.372413276128441 0.357229296557149 no 1196 0.354792585378011 1676 1206237 SGTC_1185 1319-0113 81.3 µM 0.368330483840568 0.358658236340189 no 1197 0.356313412492903 1726 4672763 SGTC_3004 9076122 71.4286 µM 0.367253340462366 0.359035557679599 no 1198 0.356715027435505 1757 44782551 SGTC_2773 thioridazine 9.09 µM 0.365811402683864 0.359540881113406 no 1199 0.357252905328423 1699 5452 An antipsychotic. SGTC_2193 5925765 200 µM 0.365587528393156 0.359619359348136 no 1200 0.357336441364418 1740 877370 SGTC_95 0471-0001 561.058 µM 0.365518152223022 0.359643680088082 no 1201 0.357362329647245 1592 4015405 SGTC_2167 5876490 200 µM 0.365418148016856 0.359678738894034 no 1202 0.357399648186302 1833 686534 SGTC_287 k060-0039 29.6 µM 0.360973473817376 0.36123811171398 no 1203 0.359059638428298 1786 5861974 SGTC_1088 bifonazole 369 nM 0.360896014547938 0.361265308121906 no 1204 0.359088591513385 1671 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_208 k072-0098 12.366 µM 0.360514807203662 0.361399162490838 no 1205 0.359231092753553 1696 5948901 SGTC_1447 4239-0816 81.9 µM 0.358968153745045 0.361942417034342 no 1206 0.359809456639164 1627 1341554 SGTC_1254 0550-0035 264 µM 0.357933368542773 0.362306035781534 no 1207 0.360196589174882 1772 15121435 SGTC_717 1532-0246 73.2 µM 0.357054657347934 0.362614908429663 no 1208 0.360525444113256 1677 9561992 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.356585520055903 0.3627798498429 no 1209 0.36070105955776 1659 61125 An anti-inflammatory. SGTC_699 0375-0592 111 µM 0.354878280473926 0.363380303602519 no 1210 0.361340390248804 1794 762578 SGTC_3280 9140961 49.47 µM 0.353022997424769 0.364033206556839 no 1211 0.362035599836049 1687 4901226 SGTC_515 4092-1064 102 µM 0.3497056220702 0.365201625771285 no 1212 0.363279816990084 1834 717353 SGTC_1498 4478-3555 97.6 µM 0.347912151840449 0.365833829721689 no 1213 0.363953079442257 1798 3437919 SGTC_727 3032-0951 202 µM 0.346918187090604 0.366184362561435 no 1214 0.364326391439485 1743 3652836 SGTC_311 1315-0136 58 µM 0.345342165819987 0.366740393047116 no 1215 0.364918575259274 1785 6759207 SGTC_3235 9132602 49.47 µM 0.344138875841418 0.367165109925585 no 1216 0.36537092386465 1738 4912240 SGTC_34 0469-0683 81.75 µM 0.339610260553909 0.368764997335363 no 1217 0.367075025068688 1789 3690923 SGTC_2683 piperine 63.03 µM 0.338802678738273 0.369050543120968 no 1218 0.367379191583597 1725 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3325 9138760 55.175 µM 0.338313736350245 0.369223459120627 no 1219 0.367563386641734 1661 43844959 SGTC_748 act1.228 77.9 µM 0.337722645529608 0.369432535564637 no 1220 0.367786103881464 1646 4421505 YNR035C ARC35 SGTC_1009 4106-0057 9.87 µM 0.337508563930586 0.369508268516159 no 1221 0.367866778706002 1843 2928005 SGTC_662 k832-1615 104 µM 0.335607587426694 0.370180974823882 no 1222 0.368583400807577 1769 5878478 SGTC_232 clozapine 119 µM 0.335440042628204 0.370240283665914 no 1223 0.368646583102591 1757 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1961 st076550 68.7 µM 0.335345633069823 0.370273704872365 no 1224 0.368682187160255 1740 1579337 SGTC_3287 9117173 37.0625 µM 0.334897910726496 0.370432212969823 no 1225 0.368851049095411 1762 2789709 SGTC_1057 3448-5381 134 µM 0.334670728554891 0.370512651175097 no 1226 0.368936742289616 1827 5497911 SGTC_1181 1222-0449 220 µM 0.33320114170216 0.371033123207442 no 1227 0.369491228185186 1795 658318 SGTC_64 000l-0018 272.079 µM 0.331747865603702 0.371548050699741 no 1228 0.370039826993263 1700 6811119 SGTC_1020 4335-0961 93.3 µM 0.331087582627413 0.371782079419414 no 1229 0.370289165413665 1650 669075 SGTC_2887 9044784 58.44 µM 0.330577382875351 0.371962945551319 no 1230 0.370481866210604 1751 6465546 SGTC_575 k072-0246 11.9 µM 0.330237126716803 0.372083582281785 no 1231 0.370610397931221 1750 6796779 SGTC_2340 7987427 183.45 µM 0.329704202773182 0.372272553989584 no 1232 0.37081173890455 1775 2239331 SGTC_600 1495-0418 41.6 µM 0.328994820724642 0.372524144427041 no 1233 0.371079801397116 1737 5377768 SGTC_2839 9003951 25.97 µM 0.328456577177002 0.372715074949242 no 1234 0.371283235536267 1795 2990634 SGTC_18 0111-0177 500 nM 0.327594361531589 0.373020992891858 no 1235 0.371609192869435 1754 721752 SGTC_1211 1056-0033 32.3 µM 0.326893177442989 0.373269835176746 no 1236 0.37187434073862 1862 6741922 SGTC_2109 5483026 200 µM 0.323668734989122 0.374414832319181 no 1237 0.373094421777638 1750 759335 SGTC_1037 k284-1091 78.7 µM 0.323056438638971 0.374632383834988 no 1238 0.373326249882359 1710 3334711 SGTC_581 0958-0271 211 µM 0.322794824414414 0.374725348662676 no 1239 0.373425316445168 1700 4591145 SGTC_963 1269-2853 151 µM 0.32154684411884 0.375168919599581 no 1240 0.373898009452859 1673 3668223 SGTC_865 0488-0499 301 µM 0.321518815043132 0.375178883901358 no 1241 0.373908628105906 1855 9634651 SGTC_2151 5563267 85.4165 µM 0.321384718605478 0.375226556171639 no 1242 0.373959431088839 1745 5310824 SGTC_1253 0550-0034 176 µM 0.320952459174685 0.375380240549985 no 1243 0.374123209239276 1743 5969915 SGTC_1052 3253-3998 198 µM 0.320455459633604 0.375556966901655 no 1244 0.374311544757856 1714 5450317 SGTC_395 anisomycin 6.25 µM 0.318468578136647 0.376263735780594 no 1245 0.375064762935167 1752 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_11 0438-0307 1.3 µM 0.316548239427489 0.376947228781293 no 1246 0.375793208131194 1865 4011476 SGTC_317 4495-0002 170 µM 0.314076808352426 0.377827435833948 no 1247 0.376731351599128 1725 15991618 SGTC_371 0195-0006 7.36 µM 0.313922232134291 0.377882509721506 no 1248 0.37679005225573 1676 3928593 SGTC_1939 st074455 53.6 µM 0.312085022515992 0.378537278049663 no 1249 0.3774879543957 1898 1644229 SGTC_1126 isoteolin 1.0172 µM 0.309764853685632 0.379364667873386 no 1250 0.378369890261925 1669 133323 SGTC_2970 9090938 41.86 µM 0.309197090764783 0.379567220780207 no 1251 0.378585803393311 1914 17217104 SGTC_1210 3013-0140 750 nM 0.307364321616473 0.380221297739694 no 1252 0.379283040922849 1903 905973 SGTC_3037 9091026 49.47 µM 0.30677327265343 0.380432303911364 no 1253 0.3795079766473 1812 25236398 YIL048W NEO1 SGTC_181 1447-1644 8.07 µM 0.306187184070875 0.380641574348782 no 1254 0.379731064874651 1890 534600 SGTC_771 0250-0039 27.3 µM 0.306065832533636 0.38068490883677 no 1255 0.379777261019354 1778 3005115 SGTC_2888 9058547 12.99 µM 0.305906533417129 0.38074179663195 no 1256 0.379837905665964 1709 16476514 SGTC_3005 9076496 71.4286 µM 0.305633154897016 0.380839429680975 no 1257 0.379941986851065 1854 21368410 SGTC_2584 androsterone 48.74 µM 0.305282983094021 0.380964499386124 no 1258 0.380075317622758 1813 2754130 A steroid. SGTC_86 0417-1630 471.922 µM 0.30426994151705 0.381326394091506 no 1259 0.380461121684621 1842 3634867 SGTC_1947 st076332 61.6 µM 0.304051874448436 0.38140430903921 no 1260 0.380544185336641 1877 24208416 SGTC_284 0988-0104 32.6 µM 0.303637277870883 0.381552456859891 no 1261 0.380702123982808 1845 4666532 SGTC_619 1652-1634 108 µM 0.300501058072571 0.382673683195701 no 1262 0.381897494737244 1772 5400454 SGTC_1136 pergolide 1.05886 µM 0.300414527206777 0.382704632739155 no 1263 0.381930492019566 1772 47811 A dopamine receptor agonist. SGTC_2123 5259487 200 µM 0.297872710339451 0.383614099200463 no 1264 0.382900158498053 1870 2173474 SGTC_1686 st019653 115.5 µM 0.297640676351765 0.383697153392791 no 1265 0.382988712787155 1901 97252 SGTC_2346 9031566 143.75 µM 0.29743829928162 0.383769596557567 no 1266 0.383065953696698 1880 4771086 SGTC_3353 9151644 39.2805 µM 0.296675258412699 0.38404277219398 no 1267 0.383357223988261 1789 4909158 SGTC_2917 7979103 53.79 µM 0.296198369154167 0.384213532195375 no 1268 0.383539297108764 1880 2980565 SGTC_2327 6189656 200 µM 0.293104508012416 0.385321897301283 no 1269 0.384721135563775 1887 5349088 SGTC_2194 5927483 104.545 µM 0.29233612176337 0.385597314691635 no 1270 0.385014821628008 1832 760979 SGTC_2504 purpurogallin 52.29 µM 0.29117151296972 0.386014862505529 no 1271 0.385460074236341 1759 5281571 An antioxidant. SGTC_2878 9043973 25.97 µM 0.290436541545221 0.386278440212987 no 1272 0.385741145874042 1894 6465167 SGTC_1750 st081859 2.357 µM 0.290366483700817 0.38630356731409 no 1273 0.385767940897993 1827 5291695 SGTC_1512 0259-0544 12.2 µM 0.289973592317251 0.386444491437438 no 1274 0.38591822016323 1837 18476 SGTC_2368 9071271 200 µM 0.289507839413891 0.386611569274376 no 1275 0.386096390824205 1731 27209959 SGTC_606 k015-0008 38.6 µM 0.289077180723568 0.3867660765978 no 1276 0.386261157807959 1901 1970475 SGTC_353 1988-1175 58.3 µM 0.288819639545509 0.386858483167499 no 1277 0.386359701053664 1738 2788357 SGTC_2235 salicylic acid 500 µM 0.288687255731132 0.386905985384994 no 1278 0.386410358061414 1847 338 A COX inhibitor and kinase inhibitor. SGTC_1221 2958-7315 257 µM 0.28701453558155 0.387506339793104 no 1279 0.38705059524253 1830 4562705 SGTC_658 3253-0951 102 µM 0.285006695327147 0.388227327112164 no 1280 0.387819506220588 1827 1184878 SGTC_2201 6605497 169.863 µM 0.285002243624574 0.388228926085284 no 1281 0.387821211509108 1902 670741 SGTC_1855 st056195 39.6 µM 0.280474736695571 0.389856103068875 no 1282 0.389556652570703 1935 4028379 SGTC_616 4092-0450 108 µM 0.28025913281676 0.389933639095922 no 1283 0.389639351072488 1841 787165 SGTC_1553 gossypol 38.6 µM 0.279849499634652 0.390080964508343 no 1284 0.389796486547556 1848 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_39 0986-0283 58.349 µM 0.278751916990512 0.390475790132239 no 1285 0.390217608481882 1939 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_939 1165-0479 45.3 µM 0.278104026779052 0.390708904136634 no 1286 0.390466252353474 1950 1377347 SGTC_1834 st055981 52.8 µM 0.278050361718575 0.390728214845584 no 1287 0.390486849656591 1928 471719 YDL150W RPC53 SGTC_1778 st046819 58.9 µM 0.276665745913091 0.391226544782622 no 1288 0.391018388156468 1785 671715 SGTC_2133 5320837 200 µM 0.274730977469766 0.391923176330799 no 1289 0.391761464998093 1904 2841355 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.274467593043465 0.392018037221563 no 1290 0.39186265234741 1888 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2809 7964133 12.99 µM 0.274304756515802 0.392076687856602 no 1291 0.391925214742433 1830 1253665 SGTC_3285 9112818 20.8695 µM 0.273677468359295 0.392302648084162 no 1292 0.392166247271942 1834 17017947 YPR165W RHO1 SGTC_2311 7694451 200 µM 0.27218035706306 0.392842080544571 no 1293 0.39274167233771 1858 2163142 SGTC_2524 avocatin b 10.57 µM 0.269540056450821 0.393793922995837 no 1294 0.393757060891428 1926 6710748 SGTC_1555 citronellol 128 µM 0.268096653887004 0.394314546104172 no 1295 0.394312460699382 1965 8842 A terpine precursor. SGTC_318 1488-0629 67.2 µM 0.2678937607763 0.394387743096109 no 1296 0.394390548203202 1810 3662576 SGTC_2712 st079126 47.7 µM 0.266053947741822 0.39505165553532 no 1297 0.395098830720707 1836 3152970 SGTC_3150 9097574 49.47 µM 0.265645884347593 0.395198950107089 no 1298 0.395255972101033 1949 17217476 SGTC_21 0849-0113 22.993 µM 0.265384514072957 0.395293302196576 no 1299 0.395356632290376 1805 1560156 SGTC_1933 st074711 15.9 µM 0.264357883578487 0.395663965033668 no 1300 0.395752080727178 1951 17250958 SGTC_1131 3454-3128 32.3 µM 0.264120089676844 0.395749833510095 no 1301 0.395843692032316 1903 710982 SGTC_2318 6029776 164 µM 0.263306241203532 0.396043756224232 no 1302 0.396157274795383 1888 818325 SGTC_1484 3473-2379 286 µM 0.262899115372518 0.396190812579198 no 1303 0.396314169083658 1948 671917 SGTC_1164 k060-0068 93.7 µM 0.260905929368813 0.396910976455158 no 1304 0.397082526100926 1851 5963676 SGTC_137 0438-0332 85.389 µM 0.260231211200304 0.397154840657961 no 1305 0.397342715164605 1899 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_822 1487-0950 154 µM 0.259579606173055 0.397390389223513 no 1306 0.397594034562435 1970 1958375 SGTC_2222 6885208 172.143 µM 0.259329838009867 0.397480687791434 no 1307 0.397690379632666 1881 609514 SGTC_58 0957-0393 9 µM 0.258898042699869 0.397636807505877 no 1308 0.397856954206328 1830 6997992 SGTC_3097 9117246 49.47 µM 0.258717064863077 0.397702246647347 no 1309 0.397926775942354 1825 16423892 SGTC_2997 9067075 71.4286 µM 0.255319914674065 0.398931142505709 no 1310 0.399238009926034 1900 27209819 SGTC_345 1362-0200 395 µM 0.254875490221787 0.39909198442822 no 1311 0.399409633596888 1788 1419823 SGTC_1956 st077085 54 µM 0.254059178429046 0.399387460943196 no 1312 0.399724919863693 1826 24208685 SGTC_923 1900-2434 73.3 µM 0.252685221104964 0.399884915850935 no 1313 0.400255734602941 1810 5910570 SGTC_816 0325-0417 81.3 µM 0.252425501617306 0.399978968162221 no 1314 0.400356095384985 1840 68101 SGTC_1138 3761-0006 1.03 µM 0.250766923498911 0.400579726273194 no 1315 0.400997157907673 1910 12061087 SGTC_2072 5231554 129 µM 0.25048053803335 0.400683482592292 no 1316 0.401107876748393 2021 789545 SGTC_983 1491-0821 12.2 µM 0.250174947426713 0.400794204585896 no 1317 0.401226029204698 1960 46495113 SGTC_2088 5278280 127.392 µM 0.250003308260569 0.400856396612134 no 1318 0.401292395118721 1879 791502 SGTC_1162 k048-0130 20.1 µM 0.249373585803893 0.401084592824631 no 1319 0.401535907665588 1841 6797406 SGTC_1809 st050081 57.6 µM 0.248348283978432 0.401456209626708 no 1320 0.401932471830136 1941 5036894 SGTC_159 3970-0959 50 µM 0.247467391240361 0.40177555710812 no 1321 0.402273262411181 1953 6615653 SGTC_42 0133-0086 60.653 µM 0.247186777642915 0.401877300926311 no 1322 0.402381838884218 1811 162923 Model of phenazepam hydroxylation. SGTC_2187 6125751 200 µM 0.244646513266522 0.402798642181486 no 1323 0.403365072901034 1903 874498 SGTC_721 1187-1332 279 µM 0.242934825218887 0.403419767797887 no 1324 0.404027943457296 1844 25730 SGTC_2297 7971671 152.32 µM 0.242924053152973 0.403423677464563 no 1325 0.404032115936551 1953 909016 SGTC_3080 9117754 49.47 µM 0.24205645436103 0.403738599707011 no 1326 0.404368209660782 1981 9550191 SGTC_3257 9139206 32.98 µM 0.242016144512281 0.403753232952058 no 1327 0.404383826761388 1962 4910041 SGTC_37 0566-0070 1.56 µM 0.241774722219461 0.403840876674605 no 1328 0.404477363325196 1965 1626686 SGTC_2186 6124449 200 µM 0.241094767484288 0.404087747104875 no 1329 0.40474083406322 1939 3834182 YLR033W RSC58 SGTC_1459 k035-0031 35.7 µM 0.239950520164342 0.404503273933668 no 1330 0.40518430762249 1785 3877128 YMR208W ERG12 SGTC_2493 resveratrol 26.09 µM 0.239731384264018 0.404582864181007 no 1331 0.405269251579565 1854 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1268 0828-0275 2.46 µM 0.238665942441941 0.404969889288855 no 1332 0.405682313814057 1935 745337 SGTC_940 3232-1287 54.8 µM 0.237967399908473 0.405223687554295 no 1333 0.40595318952898 2038 1585493 YIL048W NEO1 SGTC_937 3122-0005 46.7 µM 0.237455291248996 0.405409774982242 no 1334 0.406151799894389 1998 759535 SGTC_3148 9097893 49.47 µM 0.236611343189738 0.405716491154278 no 1335 0.406479159734253 1776 17174100 SGTC_3140 9094243 49.47 µM 0.235709872951725 0.406044176563639 no 1336 0.406828904114908 2073 19291112 SGTC_399 oxolinic acid 75 µM 0.23177418296079 0.407475572378062 no 1337 0.408356705047379 1888 4628 A DNA gyrase inhibitor. SGTC_3044 9093193 49.47 µM 0.23093765573073 0.407779974176759 no 1338 0.408681618137242 1818 25236277 SGTC_2302 7771753 200 µM 0.230893108015925 0.407796186096285 no 1339 0.408698922546985 1814 2203047 SGTC_462 ag-879 158 µM 0.230711289989718 0.407862355419291 no 1340 0.408769550992112 1997 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2855 9016525 58.44 µM 0.227861988317723 0.408899648457074 no 1341 0.409876767152772 1928 43811474 SGTC_3132 9126706 49.47 µM 0.227332807667117 0.409092368065027 no 1342 0.410082482012949 1930 850858 SGTC_1043 0916-0009 19.3 µM 0.226431004788009 0.409420841679684 no 1343 0.410433107860514 2066 3101130 SGTC_2473 5854593 8.94 µM 0.225599425380723 0.409723793394768 no 1344 0.410756493904973 1877 2872951 SGTC_410 α-linolenic acid 100 µM 0.224310184208343 0.410193581839088 no 1345 0.411257976125786 1980 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1944 st076371 56.9 µM 0.22354497607876 0.410472478139034 no 1346 0.411555691385285 1838 24208455 SGTC_1764 st044502 93.5 µM 0.223263020279699 0.410575254321467 no 1347 0.411665403205099 1911 8407 SGTC_2196 6573537 42.6665 µM 0.223135746166887 0.41062164923438 no 1348 0.411714929097565 2026 2903087 SGTC_1437 4092-1038 11.6 µM 0.222387563204543 0.410894407756416 no 1349 0.412006096281476 1918 3977136 SGTC_228 caffeine 993.056 µM 0.220350668829648 0.411637198508663 no 1350 0.412799030861367 2011 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_785 1270-0111 65.3 µM 0.219846132136025 0.411821236088147 no 1351 0.412995495090275 2006 6741994 SGTC_2708 st078559 56 µM 0.217895476215739 0.41253295020191 no 1352 0.413755275962556 2007 17250902 SGTC_2289 7946404 165.07 µM 0.217008437864552 0.412856689309561 no 1353 0.414100884581983 1900 1246120 YPR165W RHO1 SGTC_907 3448-6986 75.5 µM 0.216169173334879 0.413163047163084 no 1354 0.414427940785349 2014 590582 SGTC_3283 9109332 35.8195 µM 0.215944816716029 0.413244953325804 no 1355 0.414515381235028 1940 17027281 SGTC_1308 1187-1617 41.4 µM 0.214015243187608 0.413949540771781 no 1356 0.415267585111806 1901 2882570 SGTC_3220 9131269 49.47 µM 0.212088771439204 0.414653272036649 no 1357 0.416018889769974 1991 17722206 SGTC_879 0831-1030 162 µM 0.211968764441037 0.414697119130311 no 1358 0.416065701481886 1886 1549252 SGTC_3262 9137218 49.47 µM 0.210481424233979 0.41524063836528 no 1359 0.416645974124357 1975 17650664 SGTC_334 1502-1024 68.5 µM 0.209678681500016 0.415534052394474 no 1360 0.416959232680755 1960 3296216 SGTC_194 1486-1323 56.904 µM 0.20947816682432 0.415607350754659 no 1361 0.417037488824983 1896 5178754 SGTC_142 0335-0849 62.6745 µM 0.207706656808846 0.416255055483786 no 1362 0.417729009827155 1957 3889043 YPR107C YTH1 SGTC_1375 2910-0797 186 µM 0.207535982123484 0.416317470109073 no 1363 0.417795647326965 1939 742508 SGTC_2156 5649887 115 µM 0.207435906396363 0.416354068134811 no 1364 0.417834721567049 2039 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_827 3253-0474 693 µM 0.207308641517071 0.416400610371249 no 1365 0.417884412894223 2050 5402065 SGTC_2662 daunorubicin 22.37 µM 0.206681375310438 0.416630025983009 no 1366 0.418129351846927 1998 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2271 7849410 118.62 µM 0.206569073942661 0.416671101954011 no 1367 0.418173207363476 2087 972430 SGTC_2581 avocatin a 64 µM 0.205019123650639 0.41723811311399 no 1368 0.418778591931141 1934 6710728 A skin care supplement. SGTC_2806 7952793 58.44 µM 0.204778997456884 0.417325972802726 no 1369 0.418872398440002 1958 2972490 SGTC_288 1315-0019 35.1 µM 0.203983763916092 0.41761696997388 no 1370 0.419183093339679 1955 6811474 SGTC_509 pifithrin 175 µM 0.203463445360015 0.41780739284595 no 1371 0.419386407228319 2033 4817 A p53 inhibitor. SGTC_578 3460-0051 92 µM 0.203138032196479 0.41792649528232 no 1372 0.419513572998805 2066 2876744 SGTC_2059 5238311 157 µM 0.202726513694131 0.418077123373044 no 1373 0.419674399264715 1911 703021 SGTC_945 3381-0768 11.3 µM 0.202056018819105 0.418322570300063 no 1374 0.419936465268711 2051 1126236 YIL048W NEO1 SGTC_1974 st069448 26.9 µM 0.200527430711136 0.418882256742857 no 1375 0.420534053522057 2067 6323587 YNR016C ACC1 SGTC_1696 st025591 34.7925 µM 0.198757848344292 0.41953038730531 no 1376 0.421226085106305 1956 2787147 SGTC_1637 st007924 17.4 µM 0.198581547685096 0.419594971506453 no 1377 0.421295044474855 1941 683336 SGTC_2099 5377090 177.372 µM 0.198508217730738 0.419621835098487 no 1378 0.421323727933737 1933 2243829 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.198046832416826 0.419790866931749 no 1379 0.421504211185531 1944 689007 SGTC_814 3342-0569 96 µM 0.197454317457997 0.420007960756597 no 1380 0.421736013502743 1999 4346283 SGTC_2528 xanthyletin 44.79 µM 0.19739961671391 0.420028004000052 no 1381 0.421757414768663 1911 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.197257823931076 0.420079960150378 no 1382 0.421812891233291 2032 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_112 phenothiazine 287.218 µM 0.19719419576347 0.420103275433267 no 1383 0.421837786275519 2077 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_648 0375-0473 33.3 µM 0.197081394373635 0.420144609959462 no 1384 0.42188192151177 1965 1713139 SGTC_857 0438-0306 1.35 µM 0.193415717549116 0.42148832393303 no 1385 0.423316703509468 1976 4686136 SGTC_3226 9131256 49.47 µM 0.192216539638066 0.421928101616691 no 1386 0.423786295356225 2005 17178073 SGTC_971 1315-0384 26.7 µM 0.19174819734185 0.422099884496164 no 1387 0.423969725200403 1896 6769120 SGTC_2154 5570129 200 µM 0.191394099276824 0.422229773670499 no 1388 0.424108421355224 2054 673366 SGTC_1998 st075797 76.8 µM 0.190815522470989 0.422442023648955 no 1389 0.424335063480778 2076 24208315 SGTC_2961 9083290 32.55 µM 0.190636731725724 0.422507617306867 no 1390 0.424405105079911 2064 17741490 SGTC_854 0422-0053 192 µM 0.189196361470039 0.42303612980034 no 1391 0.424969459646229 2052 3596728 SGTC_3236 9132701 49.47 µM 0.189056827885885 0.423087335985612 no 1392 0.425024138789874 1943 24282524 SGTC_526 4469-0568 170 µM 0.18798805404735 0.423479598792309 no 1393 0.425443007860541 1878 2901964 SGTC_89 0302-0250 142.109 µM 0.18752029317489 0.423651300900727 no 1394 0.425626357119384 2103 4203518 YLR208W SEC13 SGTC_645 0845-0943 5.41 µM 0.187328079494973 0.423721861443034 no 1395 0.425701704203158 1981 1885106 SGTC_1547 harmine 94.2 µM 0.185574688257679 0.424365633977788 no 1396 0.426389152296066 2021 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2803 7707263 71.43 µM 0.184341050345474 0.424818695716205 no 1397 0.426872956087131 1945 2199229 SGTC_3196 9111891 49.47 µM 0.183000209646492 0.42531124103039 no 1398 0.42739892706064 2077 18891510 SGTC_282 k297-0036 65.7 µM 0.182804396640577 0.425383180885318 no 1399 0.427475749362852 2030 5061378 SGTC_3181 9108277 49.47 µM 0.179114615220396 0.426739233711811 no 1400 0.428923853149537 1975 17097298 SGTC_1065 prochlorperazine maleate 2.48 µM 0.177933447847053 0.427173515170521 no 1401 0.42938762119419 2055 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1665 st014639 11.4 µM 0.177118408091539 0.427473233480801 no 1402 0.429707691476616 2072 981133 YIL048W NEO1 SGTC_951 1171-0579 82.7 µM 0.177051522574194 0.427497831460106 no 1403 0.429733959815932 2032 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1314 1222-0010 41.1 µM 0.176860067006808 0.427568243179369 no 1404 0.429809152996752 2001 3526027 SGTC_1847 st056231 15 µM 0.175733559849118 0.427982585986555 no 1405 0.430251634315538 2076 5393180 SGTC_2838 9002687 71.43 µM 0.175506021412529 0.428066287001129 no 1406 0.43034101990571 1896 6457060 SGTC_465 cgp-37157 41 µM 0.173532652832275 0.42879233467695 no 1407 0.431116381978252 2117 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2310 7668677 200 µM 0.173425846277666 0.428831638162143 no 1408 0.431158355258812 2041 2197143 SGTC_1388 3346-4487 254 µM 0.172048706711943 0.429338471492389 no 1409 0.431699618723104 2051 3345614 SGTC_3313 9133968 57.047 µM 0.17160730789368 0.429500945687705 no 1410 0.431873130910876 2048 1494643 SGTC_2987 9018338 71.43 µM 0.169856853940106 0.430145386437298 no 1411 0.432561356762271 2132 5055682 SGTC_2199 6590217 200 µM 0.168769040713348 0.430545965677515 no 1412 0.432989155449477 2068 703109 SGTC_1985 st071382 65.5 µM 0.16817430615679 0.430765002564083 no 1413 0.433223076877822 2104 6123237 SGTC_381 3461-2219 42.7 µM 0.167054030898115 0.431177650485593 no 1414 0.433663767839223 2086 2883159 SGTC_2067 5224629 34.075 µM 0.165145800227836 0.431880710689392 no 1415 0.434414612261352 1964 2835000 SGTC_2028 5153890 36.43 µM 0.164616968523836 0.43207558942689 no 1416 0.434622737240669 2012 2830968 YPR165W RHO1 SGTC_1090 efavirenz 20.7 µM 0.164425534454845 0.432146138498527 no 1417 0.434698081769043 2046 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1343 1487-0095 224 µM 0.161328479124039 0.43328779337669 no 1418 0.435917346972248 2129 4560101 YGL055W OLE1 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.160401737546072 0.43362952303905 no 1419 0.436282310489072 1948 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2955 9076254 12.21 µM 0.16033544465901 0.433653969995603 no 1420 0.436308419618284 2116 16459619 SGTC_1294 1000-1494 117 µM 0.160082336298569 0.433747311590425 no 1421 0.436408107659199 1968 712797 YDL207W GLE1 SGTC_2004 4023728 41.89 µM 0.159898832561906 0.433814986622118 no 1422 0.436480384084082 2135 360084 YDR527W RBA50 SGTC_1901 st060216 58.6 µM 0.157155910838693 0.434826789187463 no 1423 0.437560987249807 2098 688792 SGTC_2873 9040596 71.43 µM 0.156769749637446 0.434969269868401 no 1424 0.437713157155593 1953 6463863 SGTC_2000 st075254 36.4 µM 0.156333383893048 0.435130284523546 no 1425 0.437885121648261 2028 17234175 SGTC_996 3970-0799 1.8 µM 0.15508837953171 0.435589737892021 no 1426 0.438375821566468 2116 6615648 YGL040C HEM2 SGTC_2074 5212007 75.395 µM 0.155052041888384 0.435603149156169 no 1427 0.438390144933929 2152 758611 SGTC_1949 st076024 69.1 µM 0.154975720366332 0.435631317654741 no 1428 0.438420229184106 2093 2921930 SGTC_224 benfluorex 43.875 µM 0.154396110921072 0.43584524866689 no 1429 0.438648709964187 2134 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1817 st052116 64.4 µM 0.154276720296563 0.435889317496432 no 1430 0.438695776030353 2107 4361398 SGTC_1458 k015-0034 6.33 µM 0.153881189833677 0.436035319271865 no 1431 0.438851707888677 1947 3598957 SGTC_2189 6047310 154.431 µM 0.153445078001302 0.436196310912426 no 1432 0.4390236493343 2067 711535 SGTC_2617 dihydrotanshinone i 20.83 µM 0.152669304270224 0.436482715599438 no 1433 0.439329534294568 2034 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1444 4112-3581 28 µM 0.151899466229835 0.4367669618354 no 1434 0.439633114647949 2044 2877249 SGTC_2810 7959871 45.46 µM 0.151765088321912 0.436816581355827 no 1435 0.439686109298998 2087 2974535 SGTC_2616 abietic acid 100 µM 0.150722107193956 0.437201739587994 no 1436 0.440097466718501 2179 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2215 7188065 200 µM 0.149522230549913 0.437644910731692 no 1437 0.440570784549143 2131 940217 SGTC_61 0978-8327 98.565 µM 0.143798644424874 0.439759968770493 no 1438 0.442829736671529 2171 6150059 YHR072W ERG7 SGTC_2928 9011484 9.79 µM 0.142902095484798 0.440091431224862 no 1439 0.443183751801206 2036 2994751 SGTC_2900 5328528 85.29 µM 0.142490362399546 0.440243666847608 no 1440 0.443346345694708 2109 795359 SGTC_369 0957-0393 4.5 µM 0.141513244124861 0.440604985275263 no 1441 0.44373224901615 2009 6997992 SGTC_834 0312-0008 75.7 µM 0.14140626252495 0.440644547900243 no 1442 0.443774503602123 2128 6385573 YIL048W NEO1 SGTC_3070 9117005 49.47 µM 0.141042327498951 0.440779138327789 no 1443 0.443918252018389 2166 8779016 SGTC_1844 rapamycin 4 nM 0.140140267194274 0.441112767671271 no 1444 0.444274582939074 2055 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3050 9093513 49.47 µM 0.138937576362524 0.441557650966099 no 1445 0.444749738638023 2118 25236664 SGTC_1682 st012968 530 nM 0.134525675908863 0.443190269356648 no 1446 0.446493454589971 1984 24207270 SGTC_2937 9044753 11.33 µM 0.132968337828237 0.443766792266829 no 1447 0.447109210429653 2154 6465530 YGL099W LSG1 SGTC_3301 9125354 19.7965 µM 0.132236420449911 0.444037787558882 no 1448 0.447398647351242 2123 41905162 SGTC_2128 5255449 168.493 µM 0.130603217819445 0.44464258142385 no 1449 0.448044598540956 2124 736008 SGTC_2608 thymoquinone 42.66 µM 0.129920361987887 0.444895489148974 no 1450 0.44831471714502 2194 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_187 1488-2104 32.728 µM 0.129521084362377 0.445043379073753 no 1451 0.448472671279924 2154 2852859 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.129336182338892 0.44511186821459 no 1452 0.448545821245863 2212 688664 SGTC_2143 5623677 140.463 µM 0.127391526843518 0.445832282506289 no 1453 0.449315261101111 2162 5375313 SGTC_1749 st037932 54.2 µM 0.126424218584142 0.446190696905218 no 1454 0.449698066149709 2077 594497 SGTC_1159 4092-0538 61.2 µM 0.126117302087966 0.446304427137837 no 1455 0.449819535870684 2184 717301 SGTC_298 1391-0729 10 µM 0.125923102691627 0.446376391477641 no 1456 0.44989639746799 2091 3237558 SGTC_1562 morin hydrate 59.1 µM 0.125286528255794 0.446612298809749 no 1457 0.450148358520501 2092 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1857 st056007 79.3 µM 0.123285575407656 0.447353952108332 no 1458 0.450940481424319 2197 619834 SGTC_2011 4012611 177 µM 0.122725898669538 0.447561429390389 no 1459 0.451162077359567 2093 2049887 SGTC_295 k015-0027 31 µM 0.122627725427859 0.447597824589206 no 1460 0.451200949210277 2120 3887424 SGTC_2894 9048625 32.47 µM 0.122356501550141 0.447698376143063 no 1461 0.451308343165936 2193 4092861 SGTC_2014 4013930 200 µM 0.121843990502367 0.447888389906382 no 1462 0.451511287046092 2214 64556 SGTC_2625 euphol 100 µM 0.121187652688613 0.44813174498272 no 1463 0.451771201880673 2205 6708538 A triterpene alcohol. SGTC_2601 securinine 100 µM 0.120447273698377 0.448406284035136 no 1464 0.452064422478295 2094 442872 A GABA receptor antagonist. SGTC_2699 st077704 54.6 µM 0.120376984774167 0.448432349073878 no 1465 0.452092261151103 2100 645852 SGTC_2992 9074591 71.4286 µM 0.120021400081139 0.44856421292784 no 1466 0.45223309784163 2218 17741321 SGTC_2245 6637752 200 µM 0.118427249329719 0.449155452171636 no 1467 0.452864567928178 2191 681890 SGTC_2266 7929956 200 µM 0.11770515439054 0.449423300256232 no 1468 0.453150641280995 2210 2967153 SGTC_1891 st059073 26.2 µM 0.117662956286152 0.449438953595375 no 1469 0.453167359715925 2224 688754 SGTC_2441 5730946 39.09 µM 0.117015570177726 0.449679110589642 no 1470 0.453423857514496 2138 1774275 SGTC_2198 6589944 200 µM 0.116426617104305 0.449897607040838 no 1471 0.453657220718316 2157 5290268 SGTC_1200 1643-0193 18.4 µM 0.115924192382315 0.450084014237303 no 1472 0.453856311102963 2210 5403974 SGTC_2634 4'-methoxyflavone 100 µM 0.114454907239264 0.450629204370809 no 1473 0.454438595117446 2099 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2478 5763493 32.33 µM 0.113159594314105 0.451109918014684 no 1474 0.454952014457682 2143 1365576 YLR208W SEC13 SGTC_1323 1348-1351 11.2 µM 0.112992062604528 0.451172097261386 no 1475 0.45501842401877 2073 6989654 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.112735329339909 0.451267385911168 no 1476 0.455120195510425 2209 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_398 bronopol 33.3 µM 0.111343925625206 0.451783865486928 no 1477 0.455671812160945 2109 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_344 k064-0035 6.43 µM 0.110386331844917 0.452139365239813 no 1478 0.456051496245224 2058 5088750 SGTC_409 arachidonic acid 100 µM 0.10994298657392 0.452303966973488 no 1479 0.456227295402552 2213 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_331 k048-0133 24.5 µM 0.108477766163237 0.452848020610429 no 1480 0.456808358229198 2192 6813582 SGTC_556 4058-0063 51.5 µM 0.108186207889181 0.45295629023292 no 1481 0.456923992624638 2119 6615692 SGTC_1113 artemisinin 1.17947 µM 0.107385916833626 0.453253494778811 no 1482 0.457241413318413 2236 2240 An anti-malaria and mitochondrial poison. SGTC_2966 9084041 48.03 µM 0.105864229444511 0.453818676787767 no 1483 0.457845037652393 2126 17741380 SGTC_1463 k081-0032 34.1 µM 0.105603242726611 0.453915621367948 no 1484 0.457948575908566 2167 977755 SGTC_2083 5306046 65.942 µM 0.105124951608481 0.454093291676221 no 1485 0.458138330239747 2135 539837 SGTC_1339 1486-1321 22.7 µM 0.10500038074968 0.454139567393984 no 1486 0.458187753298182 2099 3469382 SGTC_2164 5685496 200 µM 0.104857809771014 0.454192530579745 no 1487 0.458244318635348 2210 759046 SGTC_2958 9077254 16.72 µM 0.104754438558578 0.454230932093214 no 1488 0.458285331911305 2122 16457351 SGTC_913 3487-1245 167 µM 0.104405339500361 0.454360622541216 no 1489 0.458423842766794 2145 4016153 SGTC_152 4469-0003 551.229 µM 0.104366072902926 0.454375210403484 no 1490 0.458439422758349 2240 697280 SGTC_75 0159-0059 199.013 µM 0.103437472233426 0.454720211044541 no 1491 0.458807886546534 2206 5377270 SGTC_2546 rhodinyl acetate 100 µM 0.102387040607443 0.455110516392949 no 1492 0.459224734854643 2240 6708682 SGTC_336 4111-0029 111 µM 0.101793852513304 0.455330944469678 no 1493 0.459460152643861 2120 3131175 SGTC_130 0136-0219 337.655 µM 0.101477522324813 0.455448498064375 no 1494 0.459585700012226 2251 234244 SGTC_3119 9125183 49.47 µM 0.100675998580628 0.455746375149115 no 1495 0.459903832454383 2224 22695334 SGTC_1387 3342-1166 1.8 µM 0.0997103199743631 0.456105291528491 no 1496 0.460287153611013 2145 3418228 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.0985518270005496 0.456535918983592 no 1497 0.46074706010989 2258 16623 A steroid. SGTC_383 2324-0395 7.37 µM 0.0972022960294162 0.457037622177071 no 1498 0.461282872356927 2189 3146421 SGTC_60 0986-0278 202 µM 0.0963892520825663 0.457339913443475 no 1499 0.461605713986424 1980 3110598 SGTC_1251 0490-5699 265 µM 0.0963421180045916 0.457357438740825 no 1500 0.461624430656176 2236 3883818 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.0940569724634756 0.458207195747723 no 1501 0.462531949898815 2214 6708561 SGTC_2367 9070478 135.38 µM 0.0939394792101883 0.458250892129269 no 1502 0.462578616304717 2199 572802 SGTC_2354 9060492 162 µM 0.0935144823286283 0.458408954996398 no 1503 0.462747422438193 2213 6471895 SGTC_1850 st056238 17 µM 0.0924580762545843 0.458801877077486 no 1504 0.463167049398473 2237 5393177 SGTC_2382 9035899 200 µM 0.0916400804368115 0.459106151977118 no 1505 0.46349200291518 2217 6462679 SGTC_205 1486-1330 71.903 µM 0.0916332995066901 0.459108674421476 no 1506 0.463494696780553 2210 4118834 SGTC_1821 st053465 65.6 µM 0.0910754822181417 0.45931618301026 no 1507 0.463716307008867 2160 675086 SGTC_1804 st050076 49.1 µM 0.0884889270729196 0.460278528083171 no 1508 0.464744042365575 2190 3895976 SGTC_1411 3909-8223 150 µM 0.0847771211819334 0.461659935394515 no 1509 0.466219291348995 2277 X1411 SGTC_3156 9099931 49.47 µM 0.0843435817017631 0.461821314470314 no 1510 0.466391631319321 2186 18111053 SGTC_1341 1486-1360 280 µM 0.0842070965312551 0.461872120489702 no 1511 0.4664458880074 2230 3976547 SGTC_1991 st073000 8.92 µM 0.0835604387698201 0.462112844511335 no 1512 0.466702961086404 2225 4301969 YIL048W NEO1 SGTC_3019 9081971 49.47 µM 0.0830313841766372 0.462309800048703 no 1513 0.466913292401423 2243 16451803 SGTC_3230 9131665 49.47 µM 0.0823856016919031 0.46255022336607 no 1514 0.46717004265547 2215 15943720 SGTC_53 0973-0023 39.979 µM 0.0815922321344379 0.462845611728629 no 1515 0.467485489279008 2289 674768 SGTC_665 3914-0008 307 µM 0.0807237230586003 0.463168999618236 no 1516 0.467830835054372 2210 1069549 SGTC_1816 st051957 91.6 µM 0.0798450832422249 0.463496184440248 no 1517 0.468180233759126 2240 674121 SGTC_964 1287-0107 19.4 µM 0.0798272127995784 0.463502839230146 no 1518 0.468187340350108 2235 51516812 YPR165W RHO1 SGTC_1045 1348-1485 165 µM 0.0798122132819959 0.46350842492161 no 1519 0.468193305259783 2268 6810614 SGTC_883 0850-0245 24.6 µM 0.079806183362954 0.463510670413677 no 1520 0.468195703200411 2210 6823229 YPR165W RHO1 SGTC_1908 st060353 56.5 µM 0.079789835985597 0.463516758047884 no 1521 0.468202204129372 2270 4227716 SGTC_2746 daunorubicin 9.88 µM 0.0794076762123903 0.463659073760084 no 1522 0.468354181594694 2257 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2510 benzyl isothiocyanate 8.31 µM 0.0792200312747541 0.463728954149938 no 1523 0.468428806004969 2260 2346 DNA damaging agent; causes G2/M arrest. SGTC_742 0kpi-0133 140 µM 0.0789026414709068 0.46384715505251 no 1524 0.468555031102164 2244 2728852 SGTC_2649 anisomycin 9.56 µM 0.0782753408980947 0.464080780925342 no 1525 0.468804516189691 2201 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_618 k072-0232 33.2 µM 0.0778250868771233 0.464248476900612 no 1526 0.468983595262351 2221 5872756 YGL099W LSG1 SGTC_3081 9117243 49.47 µM 0.0771214570386258 0.464510554767651 no 1527 0.469263461792825 2246 45595589 SGTC_325 2810-4341 181 µM 0.07618386662328 0.464859798796524 no 1528 0.469636408976663 2280 774970 SGTC_2033 5192550 145 µM 0.0760681360465998 0.464902909281879 no 1529 0.46968244520951 2225 182073 SGTC_1605 st000082 49.1 µM 0.0754160271111889 0.465145832310896 no 1530 0.469941853866522 2238 1114022 SGTC_2111 5486399 200 µM 0.0743487698011808 0.465543434021617 no 1531 0.470366435846258 2273 689674 SGTC_2044 5102272 200 µM 0.0738446864133481 0.465731239910936 no 1532 0.470566984724771 2202 592666 SGTC_1483 3453-0561 55.9 µM 0.0738373474091759 0.465733974253515 no 1533 0.470569904592687 2259 4546991 SGTC_2879 9041815 71.43 µM 0.0729702456174545 0.466057047602372 no 1534 0.470914897463906 2286 4942971 SGTC_2026 5148700 152 µM 0.0728140464078485 0.466115248230426 no 1535 0.470977046605782 2257 79838 SGTC_448 monastrol 171 µM 0.0726138935526914 0.466189827271711 no 1536 0.471056685226082 2242 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2257 7960413 200 µM 0.0710419769961125 0.466775580844706 no 1537 0.471682173528619 2214 2974689 YIL048W NEO1 SGTC_2142 5622915 118.518 µM 0.0701360847333776 0.467113182187228 no 1538 0.472042672971314 2202 5322196 SGTC_678 1218-2179 85.9 µM 0.0687292393917015 0.467637521895995 no 1539 0.472602571779588 2293 6820081 YOR116C RPO31 SGTC_599 1935-0052 86.5 µM 0.0671782318742163 0.468215656761173 no 1540 0.473219907209031 2287 9557311 SGTC_3324 9138759 60.749 µM 0.0666414330046249 0.468415763115104 no 1541 0.473433580136988 2239 45595710 SGTC_1955 wogonin 32.4 µM 0.0665543423220362 0.468448229285446 no 1542 0.473468247327856 2256 5281703 A flavanone. SGTC_958 1222-0007 33 µM 0.0656937441765427 0.46876905930664 no 1543 0.473810826539908 2266 7312461 SGTC_449 xestospongin c 11.1929 µM 0.0629802715438677 0.469780770672424 no 1544 0.474891107077936 2258 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_3035 9091303 49.47 µM 0.0627417002483317 0.469869730799695 no 1545 0.474986095395534 2294 25237002 SGTC_1628 st004252 77.7 µM 0.0624641782023706 0.469973217046249 no 1546 0.475096593931814 2274 692968 SGTC_909 3448-9333 149 µM 0.0623145199495164 0.470029024521048 no 1547 0.475156182850632 2261 3344074 SGTC_1021 4476-0760 85.3 µM 0.0620732402986495 0.470118998800677 no 1548 0.475252253520281 2258 746768 SGTC_961 1252-1571 372 µM 0.0602830906441991 0.470786601096431 no 1549 0.475965084581093 2299 6813498 SGTC_1782 st039423 80.636 µM 0.0596229865829653 0.471032795183024 no 1550 0.476227955144429 2154 2068169 SGTC_105 0111-0055 734.78 µM 0.0588497244308656 0.471321207072207 no 1551 0.476535901345577 2235 5179370 SGTC_1122 capsaicin 818.572 nM 0.0586802521403633 0.471384418987179 no 1552 0.476603394369232 2237 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1997 st073024 93.8 µM 0.0583047977338654 0.471524463278288 no 1553 0.476752922989774 2307 686268 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.057776026062752 0.471721700793759 no 1554 0.476963517351214 2273 17037758 SGTC_2994 9053520 71.4286 µM 0.0569033983217235 0.472047215462836 no 1555 0.477311073616118 2276 4647384 SGTC_495 decylubiquinone 155 µM 0.0568320856389774 0.472073817925698 no 1556 0.477339477295338 2160 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_706 4262-0057 46.9 µM 0.0565826857121434 0.472166854982335 no 1557 0.477438813622867 2296 883298 SGTC_3072 9116419 49.47 µM 0.0565095352039485 0.472194143602488 no 1558 0.477467949835182 2262 17170162 SGTC_1374 2889-5571 141 µM 0.0563523949421972 0.47225276483825 no 1559 0.477530539992371 2247 2853281 SGTC_2116 5511452 16.8835 µM 0.0550184217900253 0.472750428122803 no 1560 0.478061893777282 2252 870744 SGTC_2320 7373003 200 µM 0.0539126082538934 0.473163004537079 no 1561 0.478502395671135 2256 5415828 SGTC_535 2293-4129 48.2 µM 0.0519939836350937 0.473878906900243 no 1562 0.479266743647576 2321 396118 YIL048W NEO1 SGTC_2080 5212524 12.4 µM 0.0518178194842628 0.473944643840823 no 1563 0.479336928365205 2335 260183 SGTC_2795 7780010 54.55 µM 0.050887683951835 0.47429174243376 no 1564 0.479707509788886 2268 953673 SGTC_1506 4226-2149 212 µM 0.0504402395067155 0.474458722205439 no 1565 0.479885785345653 2225 991114 SGTC_380 3970-0968 6 µM 0.0498633377567956 0.474674020181885 no 1566 0.480115646586589 2306 2891601 SGTC_624 k048-0052 28 µM 0.0493552144215914 0.474863656391554 no 1567 0.480318109174794 2242 6835531 SGTC_3247 9135149 49.47 µM 0.0488358887863003 0.475057479284928 no 1568 0.480525040584383 2325 8934436 YOR116C RPO31 SGTC_1274 0865-0114 173 µM 0.0478376209015826 0.475430069710357 no 1569 0.480922826860468 2256 870624 SGTC_2790 5423970 71.43 µM 0.047664044701375 0.475494856957781 no 1570 0.480991994844134 2297 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_3221 9128209 49.47 µM 0.0471837669559158 0.475674123805851 no 1571 0.48118338260214 2284 16460723 SGTC_3074 9116018 49.47 µM 0.0470425344226222 0.475726840722451 no 1572 0.48123966373414 2303 17027303 SGTC_2137 5261020 140 µM 0.0464193854030867 0.47595944442124 no 1573 0.481487992924439 2324 763655 SGTC_3027 9089541 49.47 µM 0.0458349491653735 0.476177605192787 no 1574 0.481720901333279 2273 9943819 SGTC_2594 a-mangostin 100 µM 0.0458052466873194 0.476188692847654 no 1575 0.481732738475153 2300 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_143 4032-1194 15.74 µM 0.0442894560775271 0.476754547471325 no 1576 0.482336838130001 2323 1806963 SGTC_278 4092-0821 23.9 µM 0.0440671028032944 0.476837557383609 no 1577 0.482425457729547 2297 877900 SGTC_454 lyso-paf C-16 6.67 µM 0.0435822841660636 0.477018555511401 no 1578 0.482618686733074 2271 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_683 panaxydol 45 µM 0.0435435867622648 0.477033002680703 no 1579 0.482634110121936 2301 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1038 k292-0204 154 µM 0.0429729169263909 0.47724605829083 no 1580 0.482861561532721 2333 4454212 SGTC_2492 derrusnin 100 µM 0.0426030427939939 0.477384151700699 no 1581 0.483008984947713 2316 1715307 Part of coumarin class of compounds. SGTC_262 fenpropimorph 62.5 µM 0.0421832587911691 0.477540882371651 no 1582 0.48317630411501 2320 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_180 1486-1293 102.781 µM 0.0420560938459456 0.477588361397298 no 1583 0.483226990607644 2337 4140536 SGTC_2557 derrustone 83.84 µM 0.0409543073632749 0.477999743897589 no 1584 0.483666161358699 2180 629853 An antioxidant. SGTC_936 3005-4620 401 µM 0.0403604079135043 0.478221502458575 no 1585 0.483902897210527 2340 777207 SGTC_2384 9036245 200 µM 0.0383080981981911 0.478987874312578 no 1586 0.48472101704937 2296 6462766 SGTC_2244 6635614 200 µM 0.0372607753705771 0.47937899488395 no 1587 0.485138540239722 2287 836499 SGTC_3200 9114385 49.47 µM 0.0358057939742409 0.47992238758885 no 1588 0.485718606553881 2286 17018030 YLR208W SEC13 SGTC_1233 0325-0408 14.2 µM 0.0348508585406184 0.480279048197105 no 1589 0.486099332994248 2323 12874 SGTC_2767 sibutramine 71.45 µM 0.0346988529202305 0.480335822522522 no 1590 0.486159937807525 2344 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1291 0993-0025 5.79 µM 0.0341866972122994 0.480527116371143 no 1591 0.486364137214045 2338 4353356 SGTC_1509 1326-1131 80 µM 0.0327186744437246 0.481075458154734 no 1592 0.486949465905388 2332 768313 SGTC_2980 9014342 25.29 µM 0.0324495537984837 0.481175985097797 no 1593 0.487056772528822 2275 2996599 SGTC_2418 pentamidine 31.67 µM 0.0320599234998735 0.481321529164776 no 1594 0.487212131691294 2358 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2957 9076800 11.52 µM 0.0317133716752557 0.481450983618167 no 1595 0.487350315598117 2326 16459615 SGTC_2582 agaric acid 100 µM 0.0310481060347757 0.481699499105006 no 1596 0.487615587539378 2331 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2891 9063876 19.48 µM 0.0309442081120331 0.481738311678589 no 1597 0.48765701690693 2357 6472478 SGTC_1397 3532-0190 20.1 µM 0.029953457138171 0.482108429694413 no 1598 0.48805208616059 2336 5322280 SGTC_1347 1493-0251 600 nM 0.0295766244915949 0.482249208339015 no 1599 0.488202354054815 2353 3986378 SGTC_1398 3558-0053 112 µM 0.0293384337600202 0.482338193726267 no 1600 0.488297337188656 2318 4532369 SGTC_1806 st050005 60.3 µM 0.0288945028161341 0.482504043695264 no 1601 0.488474364955089 2319 5194765 SGTC_1066 ketoconazole 628 nM 0.0286946113008555 0.482578722970706 no 1602 0.488554077079326 2341 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2424 5537928 59.2 µM 0.0275122245991952 0.483020473904497 no 1603 0.48902559485931 2337 5382802 SGTC_1409 3909-8004 61.9 µM 0.0273919480017708 0.483065411564072 no 1604 0.489073560202181 2314 2119279 SGTC_254 nsc-64875 3.808 µM 0.0265726260597927 0.483371531758979 no 1605 0.48940030339363 2350 56993 SGTC_2759 disulfiram 3.38 µM 0.0265075974567372 0.483395828575137 no 1606 0.489426236917715 2350 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2218 6965428 192.983 µM 0.0245050222628587 0.484144086011791 no 1607 0.490224888866335 2350 675684 SGTC_493 zm226600 134 µM 0.0243699777402433 0.48419454711432 no 1608 0.490278747751669 2353 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2964 9083345 53.42 µM 0.023742677615124 0.484428949086243 no 1609 0.490528931887862 2339 17741579 SGTC_1298 1079-1278 263 µM 0.022757672129815 0.484797024925929 no 1610 0.490921786009451 2372 2840950 SGTC_2569 tetrandrine 100 µM 0.022647060123417 0.48483835912189 no 1611 0.490965902445286 2341 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_799 1310-0557 151 µM 0.0225716357006881 0.484866544291902 no 1612 0.490995984746723 2294 5354492 SGTC_676 falcarinol 140 µM 0.0212552105242833 0.485358488082429 no 1613 0.491521036291157 2373 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1384 3089-0840 101 µM 0.0195820884137167 0.485983760415283 no 1614 0.492188376234914 2369 1069836 SGTC_2971 9092186 9.93 µM 0.0192671420636155 0.486101464773997 no 1615 0.492313997947751 2356 25236400 SGTC_1946 st076057 65.1 µM 0.0191210331309453 0.486156070226347 no 1616 0.492372276242257 2380 953009 SGTC_389 tpck 16.7 µM 0.0188342074805002 0.486263266646629 no 1617 0.492486682517362 2353 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3093 9117344 49.47 µM 0.0179965061484489 0.486576349544782 no 1618 0.49282082032519 2348 24824913 SGTC_2679 rapamycin 1 nM 0.0176080861100692 0.486721520655765 no 1619 0.492975752947377 2366 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_3270 9137563 49.47 µM 0.0173318167455545 0.486824776777992 no 1620 0.493085951659749 2354 17015724 SGTC_36 0335-0881 14.2 µM 0.01617049767979 0.487258831238099 no 1621 0.493549185913472 2362 23828853 SGTC_764 1951-2361 146 µM 0.0160475457890589 0.48730478661303 no 1622 0.493598230257178 2370 5438930 SGTC_3354 9151612 71.43 µM 0.0159305540316465 0.487348514442579 no 1623 0.493644897250059 2370 27261949 SGTC_3243 9134147 49.47 µM 0.0150490888958694 0.487677983166429 no 1624 0.49399650876563 2378 24282180 SGTC_1079 idarubicin 2.36 µM 0.0147559768149167 0.48778754270704 no 1625 0.494113430583159 2375 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2421 5690543 90.72 µM 0.0143993407419475 0.487920847510655 no 1626 0.4942556926739 2342 3397993 SGTC_96 0929-0093 37.281 µM 0.0141020908127484 0.488031955764726 no 1627 0.494374266197329 2375 6991579 SGTC_140 0062-0056 502.533 µM 0.0137922780766175 0.488147760825185 no 1628 0.494497851575541 2384 3758964 SGTC_1808 st050063 61.5 µM 0.0135455090781523 0.488240001450267 no 1629 0.494596288965887 2375 4011993 SGTC_3079 9117512 49.47 µM 0.0103074549663835 0.489450421170584 no 1630 0.495887993223124 2393 7185044 SGTC_1246 0422-0085 105 µM 0.010180006512341 0.489498064844473 no 1631 0.495938835132387 2381 264295 SGTC_2226 7298446 200 µM 0.00984501538393941 0.489623294287584 no 1632 0.496072470557772 2389 3283010 SGTC_726 3448-4391 34.2 µM 0.00827525666299951 0.490210129255157 no 1633 0.496698687914904 2379 1356692 SGTC_196 k015-0023 18.111 µM 0.00739038337711613 0.490540937658093 no 1634 0.497051690440864 2388 5211998 SGTC_547 1120-0019 610 nM 0.00727975625462121 0.490582295885675 no 1635 0.497095823090108 2398 3676939 SGTC_639 0833-0042 114 µM 0.00641867034332093 0.490904218443181 no 1636 0.497439338599025 2390 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1173 0443-0020 122 µM 0.0040773351964223 0.491779571135931 no 1637 0.498373383105772 2397 5331295 SGTC_480 am 92016 50 µM 0.00400675507449406 0.491805959493293 no 1638 0.498401540270541 2396 2129 K+ channel blocker. SGTC_1687 st020778 55.3625 µM 0.00369099720963773 0.491924014861086 no 1639 0.498527508499638 2395 4259299 SGTC_3136 9095672 49.47 µM 0.00320206885142426 0.492106816504728 no 1640 0.498722561533392 2399 17217380 SGTC_2674 ligustilide 100 µM 0.00199321679995141 0.492558791887121 no 1641 0.499204822071022 2403 5319022 A signalling regulator. SGTC_636 0kpi-0074 126 µM 0.00173381017297147 0.492655782199735 no 1642 0.499308310162359 2400 616434 SGTC_2364 9055074 200 µM 0.000398604007328646 0.493155013134034 no 1643 0.49984098001255 2404 6470630 SGTC_2276 7947513 42.08 µM 0.000275829235484878 0.493200918927589 no 1644 0.49988996005719 2405 2105100 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0 0.493304052494484 no 1645 0.5 2406 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_430 0958-0115 16.4 µM -0.00122392542240755 0.49376168802112 no 1646 0.499511724522849 2412 6833180 SGTC_1786 berberine 21.6 µM -0.00308161435345422 0.494456308293695 no 1647 0.498770615688292 2409 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_704 1310-0270 142 µM -0.00319399251524434 0.494498328886584 no 1648 0.498725783508889 2416 5718033 SGTC_286 k060-0067 22.9 µM -0.00366700887730047 0.494675200462498 no 1649 0.498537078394878 2413 5985051 SGTC_2835 9006588 71.43 µM -0.00417072172536828 0.494863551302732 no 1650 0.498336127587784 2423 2345538 SGTC_736 0958-0254 92.6 µM -0.00424746083273066 0.494892246077065 no 1651 0.498305513384493 2417 6812352 SGTC_1841 st054148 70 µM -0.00519948134983687 0.495248233785057 no 1652 0.497925716399636 2418 675442 SGTC_1662 st014054 52 µM -0.0053451556887257 0.495302705928873 no 1653 0.49786760155446 2416 2838777 SGTC_520 3584-0023 682 µM -0.00563466082255175 0.495410961117359 no 1654 0.497752107457043 2430 1340790 SGTC_2837 9008476 45.46 µM -0.00626544204229707 0.495646831461357 no 1655 0.497500466617449 2429 2992805 SGTC_746 1095-0025 46.6 µM -0.00854716643641277 0.496500057173492 no 1656 0.496590215447368 2423 6749286 SGTC_1501 4491-0275 38.4 µM -0.00875552100702198 0.496577969927528 no 1657 0.496507097110573 2425 5104718 SGTC_3292 9120825 59.784 µM -0.00916978118582958 0.496732880047855 no 1658 0.49634183784904 2417 24824900 SGTC_2309 7664088 163.95 µM -0.00948797933988253 0.49685186868336 no 1659 0.496214900676043 2424 704922 SGTC_1740 st038286 13.222 µM -0.00994734159189824 0.497023645430601 no 1660 0.496031650305943 2431 716786 SGTC_361 000s-0510 1.45 µM -0.0108758173680568 0.497370847027607 no 1661 0.495661262151573 2438 660 SGTC_660 4031-1742 102 µM -0.0110084940437808 0.49742046136496 no 1662 0.495608334984643 2427 6738706 SGTC_1006 4099-6547 255 µM -0.011217843329408 0.497498747444644 no 1663 0.495524821860586 2435 3146833 SGTC_1436 4092-1007 8.32 µM -0.012289656645283 0.497899553039549 no 1664 0.495097259767659 2425 2881121 SGTC_1130 3454-2858 15.9 µM -0.0125192895381559 0.497985424764812 no 1665 0.495005656545731 2457 715628 YIL048W NEO1 SGTC_3040 9091894 49.47 µM -0.0131399201929 0.498217511418697 no 1666 0.494758081117156 2435 25236966 SGTC_2455 5377712 9.75 µM -0.0135494409905013 0.498370653257481 no 1667 0.494594720503748 2456 2243908 SGTC_3114 9122766 49.47 µM -0.014921365535289 0.498883691209127 no 1668 0.494047457293579 2450 17176985 SGTC_3205 9113483 49.47 µM -0.0149377926040808 0.498889834205419 no 1669 0.494040904571611 2429 17018033 SGTC_1523 st012844 44.7 µM -0.0149557238265348 0.498896539688873 no 1670 0.494033751847859 2471 4274103 SGTC_585 0kpi-0023 191 µM -0.0154008809824994 0.499063008854995 no 1671 0.49385618029411 2432 64601 SGTC_368 fentichlor 4.58 µM -0.0155363081690172 0.49911365269057 no 1672 0.493802159126943 2447 7329 A pesticide. SGTC_1928 4'-methoxychalcone 40.3 µM -0.0155976706141172 0.4991365995619 no 1673 0.49377768201913 2442 641818 SGTC_1044 1222-0021 1.78 µM -0.0161894780393593 0.499357909796934 no 1674 0.493541614836631 2504 4306703 SGTC_2331 7980721 200 µM -0.0162328454422898 0.499374127327864 no 1675 0.493524316019242 2460 2981221 SGTC_2872 9044037 25.97 µM -0.0172165197450633 0.499741979150742 no 1676 0.493131941645876 2441 6465195 SGTC_1184 1269-1718 139 µM -0.0172206408704303 0.499743520274814 no 1677 0.493130297798426 2440 5403821 SGTC_392 N-ethylmaleimide 8.33 µM -0.0174301706404323 0.499821875423558 no 1678 0.493046720059016 2444 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_765 1319-0117 244 µM -0.0183828176017481 0.499821875423558 no 1679 0.492666729847613 2437 3487746 YGL099W LSG1 SGTC_603 3794-0023 45.9 µM -0.0190564141539862 0.499569979238352 no 1680 0.492398050787993 2444 3802260 SGTC_551 k048-0028 34.9 µM -0.0191054563370377 0.499551639573325 no 1681 0.492378489348962 2443 6836383 SGTC_489 paxilline 115 µM -0.0191193787198409 0.499546433201734 no 1682 0.492372936136162 2463 105008 A toxic potassium channel blocker. SGTC_1438 4092-1045 4 µM -0.0203467281105366 0.499087457791106 no 1683 0.491883389924419 2442 1351342 SGTC_1047 2043-3044 82 µM -0.020745927493006 0.498938174776405 no 1684 0.491724166025357 2443 669592 SGTC_188 3229-0966 278.469 µM -0.0212801500497561 0.498738399268321 no 1685 0.491511089109873 2454 5722370 SGTC_445 e6 berbamine 66 µM -0.022743886432817 0.49819102864447 no 1686 0.490927284283716 2472 6610268 A calcium/calmodulin antagonist. SGTC_1213 1315-0166 115 µM -0.0230686542134792 0.498069580737522 no 1687 0.490797754671638 2499 768401 SGTC_249 wiskostatin 11.211 µM -0.0241459297883918 0.497666731577764 no 1688 0.490368103657779 2440 2775510 A n-wasp and actin depolymerizer. SGTC_2650 prasterone 100 µM -0.0255563841387516 0.49713929327001 no 1689 0.489805587555626 2443 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_207 4185-0010 4.486 µM -0.0259235136433268 0.497002006260095 no 1690 0.489659172585976 2440 3761753 SGTC_2736 butenafine 14.65 µM -0.0278886836093682 0.496267143107587 no 1691 0.488875467052921 2485 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3275 9138069 49.47 µM -0.0279843621278436 0.496231365020631 no 1692 0.488837311738639 2531 17617007 SGTC_1757 st041620 31.8375 µM -0.0290482657003744 0.495833530339939 no 1693 0.488413048177716 2479 5289815 SGTC_3186 9110464 49.47 µM -0.029329552494791 0.495728347008173 no 1694 0.488300878776793 2476 17018021 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.0295659105975981 0.495639964372594 no 1695 0.488206626411707 2464 688664 SGTC_1619 st003326 88.7 µM -0.0303937105559537 0.49533042247144 no 1696 0.487876530394704 2456 2849032 SGTC_2135 5326629 150.42 µM -0.0308757712105538 0.495150165263624 no 1697 0.487684306240861 2483 5020077 SGTC_1763 st044482 94.5 µM -0.0315604976192101 0.494894126849096 no 1698 0.487411273008953 2513 88505 SGTC_2261 9010538 184.68 µM -0.0332433844066904 0.49426485742008 no 1699 0.486740250736283 2528 6457250 SGTC_860 0443-0016 25.1 µM -0.0358515493834231 0.493289634314701 no 1700 0.485700364498967 2473 5337942 SGTC_2120 5538279 151.968 µM -0.0362187196125388 0.49315234819799 no 1701 0.48555397984465 2485 2058197 SGTC_22 0964-0034 14.468 µM -0.0371493169241487 0.492804398572885 no 1702 0.485182974962227 2483 138402 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0374081771280343 0.492707611902004 no 1703 0.485079776415158 2519 6708760 SGTC_2470 5664817 21.68 µM -0.0382145849482248 0.492406102407297 no 1704 0.484758296141561 2467 2859561 SGTC_3082 9117008 49.47 µM -0.0384947370173446 0.492301356775 no 1705 0.484646613813652 2501 41448529 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.0388380915708501 0.492172981186397 no 1706 0.48450973752531 2462 756377 SGTC_2013 4024628 200 µM -0.0391768649116058 0.492046319245282 no 1707 0.484374689299515 2537 5230760 SGTC_2349 9023730 187.07 µM -0.0391984461078592 0.49203825040774 no 1708 0.484366086256133 2496 4126287 SGTC_2314 7727897 200 µM -0.0395600857593084 0.491903040058611 no 1709 0.484221924730585 2487 900724 SGTC_1273 0849-0096 14.1 µM -0.0424757831860287 0.490812950265713 no 1710 0.48305970827061 2498 5286025 SGTC_1579 chlormadinone acetate 49.4 µM -0.0429289959248294 0.490643513886286 no 1711 0.482879067322584 2477 45114258 A steroidal progestin. SGTC_844 0330-0132 15.3 µM -0.0431099491674267 0.490575863869693 no 1712 0.48280694419256 2481 2828079 SGTC_69 0096-0274 206.684 µM -0.0440166076379795 0.490236910480619 no 1713 0.482445582858272 2730 6741392 SGTC_1519 esterone 74 µM -0.0456274947955095 0.489634699428291 no 1714 0.481803577155488 2484 698 A steroid. SGTC_724 3910-0327 137 µM -0.0473337444673976 0.48899686402904 no 1715 0.481123617008973 2520 2885483 SGTC_1152 3909-8331 15.9 µM -0.0480814956571509 0.488717346195603 no 1716 0.480825646736817 2499 16001939 SGTC_1987 st072290 61.9 µM -0.0486205580553442 0.488515842017187 no 1717 0.480610843190013 2549 54697379 SGTC_1699 st031318 29.054 µM -0.0489326520191291 0.488399181093576 no 1718 0.480486483736276 2554 5340658 SGTC_2344 7990960 76.95 µM -0.0496711060419213 0.488123150477592 no 1719 0.480192241032754 2513 140813 SGTC_3105 9121040 49.47 µM -0.0497492524514161 0.488093940050442 no 1720 0.480161103621588 2490 41448907 SGTC_406 estrone 100 µM -0.0499155537071852 0.488031778344989 no 1721 0.480094841344062 2502 5870 A steroid. SGTC_990 3985-0011 41.3 µM -0.050351802888473 0.487868714256516 no 1722 0.479921021677477 2552 5399565 YGL099W LSG1 SGTC_3032 9089427 49.47 µM -0.0503882643369745 0.487855085547921 no 1723 0.479906494105005 2559 17173707 SGTC_2947 9072639 7.68 µM -0.050546418885089 0.487795970061721 no 1724 0.479843479867245 2531 16488146 SGTC_265 mycophenolic acid 32.932 µM -0.0516744043637359 0.487374356084621 no 1725 0.47939406617134 2558 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1773 st048542 73.5835 µM -0.0529182869553415 0.486909438918602 no 1726 0.478898506963503 2497 3237138 SGTC_1635 st007035 42.4 µM -0.053653539123071 0.486634637260712 no 1727 0.478605599927388 2490 3716403 SGTC_2495 cafestol 54.53 µM -0.0561704922679094 0.485693970895315 no 1728 0.477602993898184 2681 16667697 An anti-infammatory. SGTC_2744 captopril 92.04 µM -0.0563421955445721 0.485629802697907 no 1729 0.477534602508915 2526 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_316 k060-0003 58.6 µM -0.0567937125903694 0.485461065502854 no 1730 0.477354761240902 2606 6152314 SGTC_1904 st060225 78 µM -0.0576213601673842 0.485151770715108 no 1731 0.47702511749304 2503 66595 SGTC_1223 0764-0573 147 µM -0.0579396995127052 0.485032808559397 no 1732 0.476898330291177 2526 1609797 SGTC_3278 9139605 49.47 µM -0.0590598490206188 0.484614223774573 no 1733 0.476452219314594 2690 7958859 SGTC_1710 st031758 61.5 µM -0.0595077062130604 0.484446870292185 no 1734 0.476273863843045 2634 5394341 SGTC_2696 st077691 74.316 µM -0.0597483679600292 0.484356941904001 no 1735 0.476178024227681 2590 757133 SGTC_893 0958-0369 48.9 µM -0.0598663558614454 0.484312853501718 no 1736 0.476131037973496 2650 6819948 SGTC_1644 st010134 20.9 µM -0.0610990746900134 0.483852236457468 no 1737 0.475640153033137 2527 3818134 SGTC_3109 9122853 49.47 µM -0.0622080754992823 0.483437866216646 no 1738 0.475198565814535 2576 1234709 SGTC_1698 5-fluorocytosine 1.055 µM -0.0637173813898909 0.482873953662435 no 1739 0.474597632260928 2523 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2185 6113692 200 µM -0.0639044230345804 0.482804072821239 no 1740 0.474523165203854 2579 874150 SGTC_1867 st057372 64 µM -0.0641336030650616 0.48271844933031 no 1741 0.474431922767332 2510 688837 SGTC_501 nsc-95397 161 µM -0.0650934363717877 0.482359856641125 no 1742 0.474049803183743 2605 262093 SGTC_1797 st048695 56.8 µM -0.0674885664507131 0.481465101488299 no 1743 0.473096381962074 2516 592262 YIL048W NEO1 SGTC_1103 duloxetine 36.1 µM -0.0683951134897329 0.481126464397269 no 1744 0.472735555796858 2657 60835 A selective serotonin reuptake inhibitor. SGTC_506 n9-isopropylolomoucine 153 µM -0.0697935715725257 0.480604102659764 no 1745 0.472178981922082 2515 6610355 SGTC_2453 5731132 22.18 µM -0.0702237049393151 0.480443442924417 no 1746 0.472007803542142 2570 1362040 SGTC_3189 9110682 49.47 µM -0.073758855697734 0.479123146374092 no 1747 0.470601133101422 2590 17122418 SGTC_739 1486-1183 203 µM -0.0740386037272101 0.479018676584312 no 1748 0.470489834103403 2538 4346692 SGTC_1789 tunicamycin 25 nM -0.0740528796098016 0.479013345402322 no 1749 0.470484154441753 2620 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2260 7964312 200 µM -0.0741263108369599 0.478985923322743 no 1750 0.47045493991387 2726 231951 SGTC_755 1995-0008 37.3 µM -0.0741361987962361 0.478982230781315 no 1751 0.470451006012976 2526 689533 SGTC_2899 9053889 58.44 µM -0.0744659489724456 0.478859090513749 no 1752 0.470319817349877 2538 6470052 SGTC_2792 7535235 81.82 µM -0.0762326759960259 0.478199367410842 no 1753 0.469616993316307 2611 1281891 SGTC_85 0868-0259 160.055 µM -0.0775995911391288 0.477688981118027 no 1754 0.469073283812906 2619 83173 SGTC_2395 5646831 180.19 µM -0.0777117637099126 0.477647099119938 no 1755 0.469028668159968 2637 6808628 SGTC_2321 7390090 138.78 µM -0.0787907335142131 0.477244255634233 no 1756 0.468599537359091 2609 649046 SGTC_789 1309-1135 70.6 µM -0.079123276620279 0.477120102218319 no 1757 0.468467284743008 2552 3092424 SGTC_709 3807-1509 243 µM -0.0808483086141699 0.476476105486222 no 1758 0.467781294532954 2530 1886677 YPL242C IQG1 SGTC_3332 9141069 11.198 µM -0.0814836042449466 0.476238949443239 no 1759 0.467528681717028 2554 17332883 SGTC_2731 amoxapine 43.43 µM -0.0820280561529604 0.476035712082303 no 1760 0.467312201522741 2548 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2049 5262831 67.185 µM -0.0829338631967153 0.475697599027137 no 1761 0.466952063920862 2576 763417 SGTC_2066 5222451 176 µM -0.0859286301920501 0.474579860111573 no 1762 0.465761576037985 2556 2281147 SGTC_3335 9143315 29.6265 µM -0.0861959271218049 0.474480106292386 no 1763 0.465655334172698 2602 4899691 SGTC_3048 9093155 49.47 µM -0.0872479500592594 0.474087512421939 no 1764 0.465237213002892 2554 25236002 SGTC_1556 plumbagin 1.48 µM -0.0873451187911564 0.47405125226276 no 1765 0.465198595713212 2553 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2859 9028643 45.46 µM -0.0875277783508076 0.473983090334369 no 1766 0.465126003113111 2663 17151580 SGTC_2413 inermin 26.06 µM -0.087598178876609 0.473956819612571 no 1767 0.465098024831264 2785 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_17 0960-0276 49.807 µM -0.0880177172340399 0.473800266664441 no 1768 0.464931297238516 2560 6821114 SGTC_1527 coumarin 137 µM -0.088191786218359 0.473735313092241 no 1769 0.464862122764349 2797 323 A hepatotoxic, DNA x-linker. SGTC_1608 st001473 40.5 µM -0.0882746943298874 0.473704376304071 no 1770 0.464829175711341 2571 7292267 SGTC_993 3909-8757 62.7 µM -0.0889729850794681 0.473443818568971 no 1771 0.464551689868009 2611 4288324 YLR208W SEC13 SGTC_2286 7945697 125 µM -0.0906862296229489 0.472804592932502 no 1772 0.463870956355359 2622 1245733 SGTC_2643 anethole 100 µM -0.0911565604930089 0.472629120796814 no 1773 0.463684095447193 2568 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2595 hexamethylquercetagetin 100 µM -0.0925473658212725 0.472110267114794 no 1774 0.463131580091279 2646 386331 SGTC_3198 9112019 49.47 µM -0.092694891027938 0.472055234138327 no 1775 0.463072977953136 2576 45595555 SGTC_74 000s-0487 160.283 µM -0.0932636689870012 0.471843061543073 no 1776 0.462847047096578 2559 677548 SGTC_2130 NSC 7 2.4545 µM -0.0935536881313332 0.471734878083813 no 1777 0.462731849854412 2631 21448 SGTC_836 0330-0104 1.35 µM -0.0948452498623006 0.471253122854548 no 1778 0.462218872327406 2582 46494820 SGTC_1727 st034309 9.9045 µM -0.0954563560797065 0.471025193572458 no 1779 0.461976177354409 2872 870305 SGTC_942 3253-1115 227 µM -0.0968332215580663 0.470511687693801 no 1780 0.461429420453886 2680 46497897 SGTC_2775 cyproheptadine 69.59 µM -0.0984881332837591 0.469894548637505 no 1781 0.460772347207597 2566 2913 A selective serotonin reuptake inhibitor. SGTC_779 1360-0071 233 µM -0.0984898102682743 0.46989392330363 no 1782 0.460771681424487 2755 7566 SGTC_881 0833-0569 170 µM -0.0998468502376119 0.469387918622528 no 1783 0.460232956376584 2587 5418700 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.100589725460848 0.46911094078485 no 1784 0.459938076614938 2574 97141 SGTC_1148 3909-7663 27.7 µM -0.101057366379507 0.468936590534299 no 1785 0.459752460712548 2732 4084526 SGTC_784 4579-0127 173 µM -0.10124553054308 0.468866439093965 no 1786 0.459677777118024 2788 1948547 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.101526198723155 0.468761802065249 no 1787 0.459566380715403 2623 6857784 SGTC_1669 st015249 58.4 µM -0.101619379602021 0.468727063405217 no 1788 0.459529398190951 2617 722793 SGTC_2324 6149169 200 µM -0.103686253354986 0.467956576187195 no 1789 0.458709168041697 2650 2888231 SGTC_952 1185-0122 232 µM -0.103695164566384 0.467953254532126 no 1790 0.458705632042998 2563 678600 SGTC_1452 4194-0072 190 µM -0.104167446812798 0.467777214469132 no 1791 0.458518233539156 2727 1343545 SGTC_607 4491-0986 66.8 µM -0.104530961515723 0.467641721073764 no 1792 0.45837399956125 2653 698981 YDR232W HEM1 SGTC_2700 st077718 96.8 µM -0.104587533581855 0.467620635217091 no 1793 0.458351553604882 2654 904970 SGTC_145 3737-0113 38.366 µM -0.106528170348783 0.466897365644981 no 1794 0.457581652932096 2691 6849351 SGTC_2496 diffractaic acid 79.83 µM -0.107358239466068 0.466588034576776 no 1795 0.457252391525225 2681 94870 An apoptosis inducer which activates caspases. SGTC_1812 st052057 4.327 µM -0.108803173979087 0.466049617863634 no 1796 0.456679303147869 2591 3645418 SGTC_2923 7992654 58.14 µM -0.108866938513259 0.466025859117007 no 1797 0.45665401499356 2629 2985126 SGTC_1655 st012546 55.1 µM -0.110151059723385 0.465547419805402 no 1798 0.456144787342237 2692 720985 YLR208W SEC13 SGTC_2415 st077333 57.7 µM -0.110652403139683 0.465360642193772 no 1799 0.455945995449332 2593 2766255 SGTC_1607 st000305 50.6 µM -0.111349591241021 0.465100914509051 no 1800 0.455669565875339 2736 5457690 SGTC_2721 ifenprodil 61.44 µM -0.112256051943301 0.464763247488462 no 1801 0.455310193475698 2687 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1432 4049-0298 68.4 µM -0.11238349626334 0.464715775044736 no 1802 0.455259670249062 2669 741646 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.112510626737279 0.464668420007673 no 1803 0.455209272162554 2778 165506 SGTC_740 k014-0057 261 µM -0.112539083053577 0.46465782033664 no 1804 0.45519799137914 2718 4012779 SGTC_3227 9130768 49.47 µM -0.113292006622505 0.464377373558463 no 1805 0.454899527116086 2622 17720899 SGTC_2149 5554786 194.827 µM -0.113862324470845 0.46416495499908 no 1806 0.454673465996981 2614 745063 YPR165W RHO1 SGTC_3229 9132204 49.47 µM -0.115339719237065 0.463614737442485 no 1807 0.454087928512406 2606 17682924 SGTC_2713 st079149 53.4 µM -0.1163082404343 0.463254074412601 no 1808 0.453704127508084 2670 3103253 SGTC_3026 9090633 49.47 µM -0.116728808971338 0.463097470270599 no 1809 0.453537480036647 2606 25236842 SGTC_1837 st055472 66.5 µM -0.118210648902622 0.462545733714489 no 1810 0.452950376257866 2759 676091 SGTC_358 0075-0058 9.45 µM -0.118818596681231 0.462319396032612 no 1811 0.452709537517711 2566 1069125 SGTC_1738 st035555 74 µM -0.119362146187153 0.46211704402072 no 1812 0.452494224904708 2704 5331140 SGTC_2561 acetosyringone 100 µM -0.119696752455441 0.461992482039736 no 1813 0.452361686514667 2607 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_570 0987-0065 62.6 µM -0.120755107847166 0.46159851867032 no 1814 0.451942504281802 2609 3104428 SGTC_730 1436-0052 41.2 µM -0.120913046401897 0.461539730671389 no 1815 0.45187995422832 2616 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1762 st045503 25.4615 µM -0.122251952936016 0.461041395834275 no 1816 0.451349741244759 2683 4645554 SGTC_81 0411-0046 9.971 µM -0.124863302720396 0.46006964019178 no 1817 0.450315885566984 2598 12925265 SGTC_1878 temozolomide 1 mM -0.125147489998964 0.459963900511473 no 1818 0.450203393608232 2619 5394 DNA alkylating agent. SGTC_2884 9058502 51.95 µM -0.126047432363985 0.459629070959841 no 1819 0.449847189182773 2714 6471554 SGTC_2096 5468907 200 µM -0.126479701894714 0.459468252365893 no 1820 0.449676107773239 2760 759785 SGTC_14 0354-0009 295 µM -0.127072902353199 0.459247572932461 no 1821 0.449441349180749 2602 1713507 SGTC_2054 5233173 129 µM -0.12728991701955 0.459166843367686 no 1822 0.449355470222081 2738 6889 SGTC_1926 methyl fluorone black 53.6 µM -0.127784802433812 0.45898275204861 no 1823 0.449159638678701 2617 72721 Reacts with homocysteine. SGTC_833 3852-0053 558 µM -0.127887834118137 0.45894442662756 no 1824 0.449118869476027 2767 3123681 SGTC_703 3875-0075 71.8 µM -0.128460217656683 0.458731520050829 no 1825 0.448892389518894 2658 2850814 SGTC_2393 9031399 185.94 µM -0.12860454567905 0.458677836961045 no 1826 0.448835284624938 2741 1526623 YDL150W RPC53 SGTC_637 1181-0519 7.26 µM -0.12928314089885 0.458425442261394 no 1827 0.448566805544372 2635 6252091 YGR060W ERG25 SGTC_1511 0906-3109 28.5 µM -0.129570523970211 0.458318558897779 no 1828 0.448453112539051 2618 2882180 SGTC_819 1013-0258 27.7 µM -0.130130159710017 0.458110428117795 no 1829 0.448231724497538 2653 5753198 SGTC_3158 9100007 49.47 µM -0.131041123709658 0.45777166153549 no 1830 0.447871387929118 2666 19297233 SGTC_3060 1327-0027 12.5 µM -0.131333884934364 0.457662796863835 no 1831 0.447755593816063 2718 16000455 YPR107C YTH1 SGTC_3252 9135871 49.47 µM -0.132167675315096 0.457352765327204 no 1832 0.447425834074635 2783 17682838 SGTC_2259 7964009 200 µM -0.133345263325125 0.45691494242692 no 1833 0.446960166120122 2820 313134 SGTC_1430 4049-0248 69.1 µM -0.133995040819376 0.456673379893534 no 1834 0.446703247962206 2733 22774488 SGTC_2755 lomerizine 42.69 µM -0.136527884339827 0.4557319187584 no 1835 0.445701991207659 2695 3949 A calcium channel blocker. SGTC_2484 5809818 12.04 µM -0.137105864258473 0.455517117528024 no 1836 0.445473558619038 2698 2870548 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.137203920692237 0.455480676992162 no 1837 0.445434805978291 2796 688751 SGTC_289 k017-0060 526 µM -0.137896691160992 0.455223234639094 no 1838 0.445161032748762 2666 5512909 SGTC_2822 7994718 71.43 µM -0.138632985083952 0.454949639028955 no 1839 0.444870088328646 2627 1018011 SGTC_901 1112-0062 60.1 µM -0.141388168369233 0.453926045498538 no 1840 0.443781650324752 2653 1908457 SGTC_786 4544-0069 423 µM -0.141584110016796 0.453853261695853 no 1841 0.443704259424969 2781 748821 YLR208W SEC13 SGTC_2045 5106652 78.05 µM -0.141795667448167 0.453774679048492 no 1842 0.443620703183351 2761 673349 SGTC_2706 st078239 82.5 µM -0.14273721507729 0.453424964778552 no 1843 0.44324886212673 2656 15434492 SGTC_2658 polymyxin b sulfate 77.05 µM -0.144148872078881 0.452900707910978 no 1844 0.442691456670386 2690 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3238 9133470 49.47 µM -0.144591560039601 0.45273632067202 no 1845 0.44251668065826 2781 3534688 SGTC_444 curcumin 90.4 µM -0.145944755244295 0.452233877061998 no 1846 0.441982500121033 2777 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1575 cyproterone acetate 48 µM -0.146092479902408 0.452179031269222 no 1847 0.441924191446683 2713 9880 An androgen receptor antagonist and liver toxin. SGTC_1977 st070720 65.3 µM -0.146848271809079 0.451898442406369 no 1848 0.441625891133752 2773 682188 SGTC_1952 st077036 64.1 µM -0.146905875111555 0.45187705807874 no 1849 0.441603157285416 2640 2937007 SGTC_2174 5790901 200 µM -0.147843484226574 0.451529004994339 no 1850 0.441233145475699 2757 786020 SGTC_1140 3229-1848 2.98 µM -0.147952586517418 0.451488507174814 no 1851 0.441190093400153 2766 2849525 SGTC_1640 st009078 66.4 µM -0.148661314352398 0.451225445889877 no 1852 0.440910444314484 2787 690618 SGTC_3117 9124945 49.47 µM -0.148869107513641 0.45114832254422 no 1853 0.440828459086141 2642 17592065 SGTC_1729 st035615 45.989 µM -0.149069573484489 0.451073920465172 no 1854 0.440749367219649 2819 17385451 SGTC_2929 9013348 24.6 µM -0.149563579805344 0.450890579495958 no 1855 0.440554472005814 2773 2995952 SGTC_471 1-acyl-paf 4 µM -0.15011731560097 0.450685083533875 no 1856 0.440336029457276 2651 16759367 SGTC_510 ag-490 170 µM -0.151591561523276 0.450138043194138 no 1857 0.43975454470723 2722 5328779 SGTC_3149 9097855 49.47 µM -0.152066832171517 0.449961707265689 no 1858 0.439567112010044 2802 25236625 YMR079W SEC14 SGTC_2015 5119600 184 µM -0.152756711601223 0.449705764316789 no 1859 0.439295068064952 2818 2828786 SGTC_3095 9117207 49.47 µM -0.152868357665153 0.449664345966473 no 1860 0.439251044751053 2810 17015229 SGTC_2945 9067681 61.76 µM -0.153355242295259 0.449483728386686 no 1861 0.439059069388961 2626 16456930 SGTC_2754 granisetron 64.02 µM -0.155987835077194 0.448507308542221 no 1862 0.438021305022516 2805 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1830 st055982 50.3 µM -0.156386834166575 0.448359348183861 no 1863 0.437864057152039 2662 455313 An antimicrobial agent. SGTC_2475 5812728 15.03 µM -0.156604961516666 0.44827846331332 no 1864 0.437778096036527 2663 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_113 0099-0221 2.5 µM -0.156991219671646 0.448135238312851 no 1865 0.437625883991566 2696 89219 SGTC_1694 st024011 44.9 µM -0.157149901901138 0.448076400704518 no 1866 0.437563355048974 2706 2787533 SGTC_564 3555-0129 330 µM -0.158040403256898 0.447746233920654 no 1867 0.437212480782641 2672 563260 SGTC_5 0352-0601 109.883 µM -0.15816686212461 0.447699350321794 no 1868 0.437162657610209 2716 762456 SGTC_701 4424-0219 185 µM -0.158317336195025 0.447643564233485 no 1869 0.437103374054271 2774 2911779 SGTC_349 k015-0014 24 µM -0.160125903842979 0.446973145240108 no 1870 0.436390948067827 2687 2196908 SGTC_3216 9129716 49.47 µM -0.160147747614285 0.446965048881966 no 1871 0.436382344685841 2741 8056934 SGTC_2336 9001819 198.65 µM -0.161083166468879 0.446618358196032 no 1872 0.436013949155912 2886 2989602 SGTC_2466 5983409 37.09 µM -0.162246303042229 0.446187326301003 no 1873 0.435555949127461 2737 2879657 SGTC_3293 9120939 62.045 µM -0.164263259969059 0.445440039058644 no 1874 0.434761951540124 2838 934087 SGTC_1208 2323-2347 50.3 µM -0.166600699522523 0.444574254872538 no 1875 0.433842121626218 2808 5412760 SGTC_543 3844-1095 191 µM -0.166720559422384 0.444529866032113 no 1876 0.433794963933824 2807 4230703 SGTC_3267 9137951 49.47 µM -0.167046867410994 0.444409024862099 no 1877 0.433666586059085 2665 16643986 SGTC_2849 9019321 12.99 µM -0.170572469551836 0.443103725496514 no 1878 0.432279973377456 2819 16489627 SGTC_3305 9127027 53.8275 µM -0.171231388922587 0.44285983887902 no 1879 0.432020913585861 2753 41905295 SGTC_1709 st033179 39.1045 µM -0.172481378556345 0.442397238279242 no 1880 0.431529549863365 2717 573381 SGTC_2018 5133068 143 µM -0.172512027983238 0.442385896414407 no 1881 0.431517503077705 2703 785362 SGTC_2614 arthonioic acid 13.39 µM -0.17315074874699 0.442149547630264 no 1882 0.431266467800638 2692 6710684 SGTC_525 k781-2675 26.7 µM -0.174686633832036 0.441581301450893 no 1883 0.430662935469168 2703 3651118 YDL195W SEC31 SGTC_655 k060-0012 42 µM -0.175530968155687 0.441268966094618 no 1884 0.430331219719616 2731 5994525 SGTC_110 0850-0284 111.64 µM -0.177538720160901 0.440526407400457 no 1885 0.429542626992975 2683 3906265 SGTC_3062 9077494 49.47 µM -0.178139211977191 0.440304358512322 no 1886 0.429306823897258 2830 16459633 SGTC_360 0957-0399 1.01 µM -0.178567329897691 0.440146061221848 no 1887 0.429138724544916 2864 6752301 YPR165W RHO1 SGTC_569 4130-2812 160 µM -0.180440229188312 0.439453666492288 no 1888 0.428403487134894 2700 743552 SGTC_1231 0242-0792 125 µM -0.180640394722577 0.439379677935014 no 1889 0.428324923513622 2713 3707635 SGTC_98 0074-0023 107.663 µM -0.181038639329957 0.439232478353696 no 1890 0.428168623644067 2794 3563821 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.181552704449409 0.439042481501797 no 1891 0.4279668841272 2728 66535 A nucleotide analog. SGTC_1895 st058434 18.3 µM -0.182575491350205 0.438664504487807 no 1892 0.427565558075706 2901 5393175 SGTC_3299 9121982 43.1275 µM -0.182979071841896 0.438515374274606 no 1893 0.427407219813523 2760 17594604 YPL160W CDC60 SGTC_1393 3470-5649 58.2 µM -0.183285268624025 0.43840223490742 no 1894 0.427287096270154 2818 4108395 SGTC_1049 3226-0134 66 µM -0.185030461850905 0.437757484351676 no 1895 0.426602571490775 2690 5702385 SGTC_1631 benzylvanillin 81.9 µM -0.185090806802856 0.437735193237781 no 1896 0.426578906067596 2876 75506 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.185738146535528 0.437496081724135 no 1897 0.426325056095446 2869 5024745 SGTC_517 1365-0151 113 µM -0.187095287020555 0.436994861307875 no 1898 0.425792961663509 2905 768657 SGTC_2517 totarol 10 µM -0.187114634870844 0.436987716470526 no 1899 0.425785376921107 2815 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_604 1000-0114 314 µM -0.187293981595329 0.436921487704884 no 1900 0.425715070742821 2881 1572745 SGTC_1277 0873-0036 22 µM -0.187947522504826 0.436680164520982 no 1901 0.425458894461084 2801 5965735 SGTC_1380 2291-0730 164 µM -0.188882479681224 0.436334967989985 no 1902 0.425092462795375 2827 2999191 SGTC_1059 3448-6867 171 µM -0.18910635429314 0.436252318191752 no 1903 0.425004730669589 2700 3934407 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.190566296631995 0.435713406604058 no 1904 0.424432698811413 2733 368090 SGTC_2924 9010168 62.78 µM -0.191072334696749 0.435526639511984 no 1905 0.424234461006658 2826 2993929 SGTC_451 chloral hydrate 100 µM -0.191094602513931 0.435518421299255 no 1906 0.424225738143908 2855 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_401 neomycin 50 µM -0.191229063748756 0.435468797313114 no 1907 0.424173067093134 2777 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2062 5245942 200 µM -0.192760468529113 0.434903692100968 no 1908 0.423573282171024 2713 1376160 SGTC_3241 9133421 49.47 µM -0.19295805423851 0.434830790459344 no 1909 0.423495909271827 2747 17018221 SGTC_798 1287-0182 476 µM -0.1932209247533 0.434733804632642 no 1910 0.423392975966203 2898 1649755 SGTC_2944 9067346 25.62 µM -0.193290524923161 0.434708126373413 no 1911 0.423365723212022 2898 6473075 SGTC_3279 9140807 49.47 µM -0.193753853897024 0.434537192988903 no 1912 0.423184310725813 2719 45595718 SGTC_2692 st077426 47.7 µM -0.194762680329792 0.434165054627105 no 1913 0.422789369769787 2879 25238571 SGTC_894 0960-0238 55.9 µM -0.195786897778813 0.433787298468235 no 1914 0.422388482831257 2735 6741907 YDL195W SEC31 SGTC_1863 st057641 20.1 µM -0.196494765035303 0.433526255225568 no 1915 0.422111464849788 2738 3921635 SGTC_217 ketoconazole 989 nM -0.196562849713188 0.433501148873771 no 1916 0.422084822504609 2826 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_178 4092-0806 87.505 µM -0.197682143177622 0.433088445863072 no 1917 0.421646880843705 2764 2169044 SGTC_2999 9069765 71.4286 µM -0.198077078634351 0.432942843667301 no 1918 0.421492379060012 2838 2097066 SGTC_153 4077-0274 519.67 µM -0.199698078785947 0.432345319607489 no 1919 0.420858358208692 3003 3121976 SGTC_1370 2001-0092 44.6 µM -0.199789010981422 0.432311805257223 no 1920 0.420822798015313 2924 790957 SGTC_1117 retinoic acid 1.10837 µM -0.200599761107063 0.432013013357286 no 1921 0.420505772441675 2927 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1756 st041558 35.5 µM -0.200913552579346 0.431897379831414 no 1922 0.420383085182453 2925 3955792 SGTC_1752 st044819 83.042 µM -0.202565823309228 0.4312886073337 no 1923 0.419737202599223 2803 441209 YML126C ERG13 SGTC_657 3534-0529 86.7 µM -0.203150779670376 0.431073121556964 no 1924 0.419508591350764 2936 1049549 SGTC_2442 5158906 48.48 µM -0.203418898262273 0.43097435908833 no 1925 0.419403814957567 2920 1893835 SGTC_2471 5466956 24.79 µM -0.203433812458963 0.430968865515839 no 1926 0.419397986899317 2802 724419 SGTC_270 tamoxifen 5.46 µM -0.203685431800173 0.430876184758193 no 1927 0.419299663641543 2956 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_359 0081-0058 15.9 µM -0.20415233869324 0.430704215680929 no 1928 0.419117227561095 3163 3494159 SGTC_2871 9038510 12.99 µM -0.204393045794647 0.430615564639245 no 1929 0.419023182066938 2798 4945164 SGTC_3167 9103034 49.47 µM -0.206758425468014 0.429744595589944 no 1930 0.4180992630919 2747 5127859 SGTC_1115 galangin 695.678 nM -0.207001874416154 0.429654973284833 no 1931 0.418004197316164 2782 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2095 5432005 200 µM -0.207316044265205 0.429539321433357 no 1932 0.417881522411375 2789 783734 SGTC_3348 9149464 3.537 µM -0.207476389590889 0.429480297622459 no 1933 0.417818914938537 2736 1951442 SGTC_1610 st001799 48.1 µM -0.2079813083033 0.42929444515496 no 1934 0.417621781023397 2745 621897 SGTC_2661 dactinomycin 12.96 µM -0.208474944133143 0.429112760885444 no 1935 0.417429072262253 2790 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1916 st067606 49.2 µM -0.208610761582726 0.429062775464911 no 1936 0.417376054441009 2881 19590279 SGTC_849 0386-0493 241 µM -0.210018569191325 0.428544721744871 no 1937 0.4168265900556 2786 726119 SGTC_1260 0700-1617 7.75 µM -0.210174800002419 0.42848723854048 no 1938 0.416765623488751 2887 2853078 SGTC_2591 skatole 100 µM -0.210430617568283 0.428393116891752 no 1939 0.416665799112289 2911 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1648 st011736 69.8 µM -0.211336988836215 0.428059673162323 no 1940 0.416312160877503 2940 2855514 SGTC_3284 9108171 64.8615 µM -0.212359263062533 0.427683651692557 no 1941 0.415913382160547 2891 8687505 SGTC_2301 7769476 200 µM -0.213123844200713 0.427402459961645 no 1942 0.415615183440128 2869 977820 SGTC_460 trequinsin 123 µM -0.21349989531249 0.427264172315482 no 1943 0.415468535381969 2840 5537 A vasodilator. SGTC_1720 st037298 9.481 µM -0.214251456919008 0.426987822623254 no 1944 0.41517548538698 2879 597396 SGTC_1453 4237-0541 195 µM -0.214747099148431 0.426805594250277 no 1945 0.414982249657148 2887 739892 SGTC_1306 1185-0270 9.02 µM -0.215447248079763 0.426548203343342 no 1946 0.414709318082426 2897 1548076 SGTC_1760 st045453 10.4495 µM -0.215868713870736 0.426393277865187 no 1947 0.414545042418997 2877 3323419 YIL048W NEO1 SGTC_51 1013-0126 23.419 µM -0.218342339633601 0.425484234115566 no 1948 0.413581193949963 3041 1627850 SGTC_373 0844-0104 25.9 µM -0.218622874201621 0.425381164127388 no 1949 0.413471916387141 2907 5375804 SGTC_3118 9124250 49.47 µM -0.219147484891883 0.425188432880035 no 1950 0.413267581032359 2861 1504786 SGTC_548 1436-0017 110 µM -0.220263930837243 0.424778333016911 no 1951 0.41283280467665 2911 9677137 SGTC_3139 9095020 49.47 µM -0.222112355935842 0.424099537179056 no 1952 0.412113209721465 2737 25236292 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.223106878544286 0.423734412356427 no 1953 0.411726162487064 2977 6728940 SGTC_2332 7982454 138.89 µM -0.223360191307807 0.423641422629083 no 1954 0.411627592206366 2858 2981748 SGTC_175 3793-3120 23.7 µM -0.223741493939306 0.423501456542002 no 1955 0.411479228410225 2817 5322297 SGTC_583 1488-1091 88.9 µM -0.224081781406787 0.423376554184292 no 1956 0.411346834187911 2853 4303273 SGTC_825 1988-2224 89.6 µM -0.22451592707634 0.423217212396428 no 1957 0.411177937604819 2796 1180859 SGTC_795 0685-0265 78 µM -0.225072849323181 0.423012827075024 no 1958 0.41096130110488 2797 302754 SGTC_1161 k007-0610 110 µM -0.225347402841537 0.422912076090656 no 1959 0.410854512858056 2887 5843850 SGTC_2452 5863136 48.41 µM -0.226239365697107 0.422584793549884 no 1960 0.41050762741189 2774 2184096 SGTC_635 k038-0028 24.7 µM -0.226969372887561 0.422316976174189 no 1961 0.410223778794221 2848 4035102 SGTC_2568 diosmetin 100 µM -0.228929401577343 0.421598079409766 no 1962 0.409461894085588 2925 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2027 5150920 200 µM -0.229056741698715 0.421551382777888 no 1963 0.409412407374015 2888 786715 SGTC_2965 9082772 38.63 µM -0.229615557828363 0.421346473525632 no 1964 0.409195258231223 2969 16459634 SGTC_682 0kpi-0099 17 µM -0.229825263142856 0.421269583315917 no 1965 0.409113776485813 2910 1714895 YML126C ERG13 SGTC_1307 1187-1599 12.2 µM -0.233930719784148 0.419764891563456 no 1966 0.407519381926091 2810 1538471 SGTC_2979 9012552 45.46 µM -0.234413588112338 0.419587992017174 no 1967 0.407331955352197 2923 17100905 SGTC_2685 mycophenolic acid 18.85 µM -0.23473773356183 0.419469249951889 no 1968 0.407206149366326 2868 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_538 2922-0838 53.3 µM -0.235722818885884 0.419108435188628 no 1969 0.406823880940213 3000 777039 SGTC_3185 9108267 49.47 µM -0.236328233929819 0.41888671890188 no 1970 0.406588989917447 2900 4910486 SGTC_2738 aclarubicin 5.55 µM -0.237380621311434 0.418501372875578 no 1971 0.406180761047743 2904 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_403 arphamenine a 50 µM -0.237976239991743 0.418283313582986 no 1972 0.405949761304546 2824 5487158 An arginine aminopeptidase inhibitor. SGTC_2647 atorvastatin 60.16 µM -0.240503643472026 0.417358297348133 no 1973 0.404969919530713 2887 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2355 9061122 103.12 µM -0.241237765755536 0.417089697953937 no 1974 0.40468542110757 2967 5302957 SGTC_1229 0139-0193 12.2 µM -0.241305008037387 0.417065097396342 no 1975 0.404659364854787 2962 3090752 SGTC_2388 9080168 200 µM -0.242012802023924 0.416806171010096 no 1976 0.404385121736544 2822 15943073 SGTC_1906 st060206 94.7 µM -0.242017688502206 0.416804383555692 no 1977 0.404383228576084 2981 5133468 SGTC_1302 1159-0335 255 µM -0.242105184712261 0.416772378079724 no 1978 0.404349330438454 2828 649284 SGTC_750 4073-0104 132 µM -0.242287531482113 0.416705678733321 no 1979 0.404278687219008 2912 22330957 SGTC_2724 maprotiline 69.64 µM -0.242843300629457 0.416502402633158 no 1980 0.404063395170926 2882 4011 A tricyclic antidepressant. SGTC_2771 fluoxetine 41.05 µM -0.242890383418024 0.416485182828945 no 1981 0.404045157727235 3025 3386 A selective serotonin reuptake inhibitor. SGTC_2645 abamectin 100 µM -0.244397747022105 0.415933972703184 no 1982 0.40346139325018 2967 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_641 4092-0595 30 µM -0.244869276545588 0.415761578497691 no 1983 0.403278825671843 2909 786260 SGTC_2784 7567673 72.73 µM -0.245467632342885 0.415542839137229 no 1984 0.40304718363788 2790 3471247 SGTC_2280 7785178 200 µM -0.245605414892432 0.415492474036042 no 1985 0.402993848567892 2848 2954328 SGTC_1980 st071811 45.7 µM -0.245835129553833 0.415408507112626 no 1986 0.402904930961082 2994 4974850 SGTC_44 0929-0055 61.211 µM -0.246035145944571 0.415335398856502 no 1987 0.402827513005642 2835 1379590 SGTC_824 1304-0008 100 µM -0.246534205753365 0.415152999629903 no 1988 0.402634364503895 2851 768245 SGTC_610 4215-0184 155 µM -0.246786202516768 0.415060905360173 no 1989 0.402536844543413 2893 5605015 SGTC_1203 3992-3522 103 µM -0.247007002207974 0.414980216150606 no 1990 0.40245140248946 3202 5322312 SGTC_733 4069-0007 56.1 µM -0.248421332996148 0.414463447217653 no 1991 0.401904214733019 2860 5717425 YNL287W SEC21 SGTC_1779 st039427 55 µM -0.249804534064154 0.413958195636925 no 1992 0.401369256608613 3041 1124498 SGTC_3260 9137109 49.47 µM -0.250244926539492 0.413797360224746 no 1993 0.401198971933663 2949 17478346 SGTC_3261 9137475 49.47 µM -0.250245305491385 0.413797221834226 no 1994 0.401198825414032 2825 17027690 SGTC_2519 cryptotanshinone 88.04 µM -0.251868828583697 0.413204421314249 no 1995 0.400571227087962 3003 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_930 2810-3379 265 µM -0.253152709731425 0.412735775002871 no 1996 0.400075104289259 3045 1015764 SGTC_79 0052-0007 94.094 µM -0.253285718536697 0.412687230810596 no 1997 0.400023715665928 3025 2801472 SGTC_2644 guaiazulene 100 µM -0.253553802612155 0.412589392287727 no 1998 0.399920145292084 2950 3515 A coloring agent. SGTC_170 4197-0004 226 µM -0.253615025465163 0.412567049485959 no 1999 0.399896493722637 2990 218692 SGTC_695 3505-6186 243 µM -0.254073538336776 0.412399727807254 no 2000 0.399719373032837 2974 1819379 SGTC_2898 9056270 58.44 µM -0.254248924942027 0.41233572949064 no 2001 0.399651627724352 2830 19154699 SGTC_690 glyoxal 20.3 µM -0.256766226836761 0.411417427320085 no 2002 0.398679621615217 2873 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2497 7-hydroxyflavone 100 µM -0.258084630467678 0.410936671912986 no 2003 0.398170796492764 3029 5281894 SGTC_1177 0983-0204 23.6 µM -0.258169703049395 0.410905654812803 no 2004 0.398137969489594 3009 766818 SGTC_3213 9129884 49.47 µM -0.258463467844559 0.410798553706454 no 2005 0.39802461985367 2979 17190742 SGTC_982 1491-0518 27.5 µM -0.259233881029598 0.410517707191185 no 2006 0.397727395545394 2878 3091256 SGTC_3083 9117465 49.47 µM -0.260175594884658 0.410174477034062 no 2007 0.397364164317795 2971 16420915 SGTC_896 0964-0007 44.5 µM -0.260326428197958 0.410119508608025 no 2008 0.397305994215699 2871 6756758 SGTC_1351 1496-0003 46.5 µM -0.260939797276865 0.409895995735682 no 2009 0.397069466951451 2993 3891978 SGTC_2791 5663188 71.43 µM -0.263610668974431 0.408923067134764 no 2010 0.396039968298872 3036 54690634 SGTC_223 busulfan 5 mM -0.263847330709051 0.408836884428804 no 2011 0.395948780891229 2960 2478 A DNA alkylator. SGTC_2624 nerol 100 µM -0.264105306727153 0.408742944937117 no 2012 0.395849387428588 2845 637566 A natural product oil. SGTC_407 eburnamonine 100 µM -0.26466009345926 0.408540942437923 no 2013 0.39563566115044 2848 3195 SGTC_90 0870-0863 4.608 µM -0.265835814418772 0.408112932950232 no 2014 0.395182829693872 2840 1738164 SGTC_978 1416-0512 87.4 µM -0.267071705521539 0.407663137299865 no 2015 0.394706976146097 2946 6814003 SGTC_2799 7812892 81.82 µM -0.267764175351569 0.40741116993599 no 2016 0.39444042398759 3053 20205235 SGTC_533 1222-0222 6.71 µM -0.269065857999651 0.406937633492144 no 2017 0.393939501616137 3075 3982874 SGTC_1574 spiramycin 23.7 µM -0.270162248011151 0.406538885530896 no 2018 0.393517717417467 2845 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2895 9054447 58.44 µM -0.270323637397711 0.406480197719698 no 2019 0.393455641020428 2889 2697450 SGTC_2330 7979373 200 µM -0.270374771564418 0.406461603674139 no 2020 0.393435973471427 2883 1863007 SGTC_873 0591-4978 488 µM -0.270838205303853 0.406293093721762 no 2021 0.393257737039084 3094 3305145 SGTC_1725 st036284 20.55 µM -0.27220772644349 0.405795221281825 no 2022 0.392731150619156 3121 707914 SGTC_2184 6075246 200 µM -0.272991454551322 0.405510375120758 no 2023 0.392429892229559 2948 2267320 SGTC_470 aa-861 153 µM -0.273085258949589 0.405476285240304 no 2024 0.392393838935328 2906 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1667 st014849 34.6 µM -0.274524578000776 0.404953305847969 no 2025 0.391840759176834 2851 5348460 SGTC_1154 4088-0362 150 µM -0.274806505850578 0.404850886659728 no 2026 0.3917324497634 2868 6618304 SGTC_3218 9131285 49.47 µM -0.2751461395634 0.404727512651632 no 2027 0.391601982388468 3058 17156417 SGTC_2818 7996756 12.99 µM -0.275403071746398 0.404634186767921 no 2028 0.391503292195381 2839 2241621 SGTC_1466 k213-0079 57.5 µM -0.275571258026362 0.404573099136687 no 2029 0.39143869396279 2882 3657981 SGTC_2986 9022445 71.43 µM -0.276448302154107 0.404254582051367 no 2030 0.391101880907067 3095 6459286 SGTC_3209 9113616 49.47 µM -0.276501330375743 0.404235325765771 no 2031 0.391081518985634 3094 16649353 SGTC_323 4013-0906 34.3 µM -0.277042609573 0.404038782824579 no 2032 0.390873694206674 2979 2910086 SGTC_2729 fluphenazine 10.66 µM -0.277088111069093 0.404022261959024 no 2033 0.390856225273321 2886 3372 An atypical antipsychotic. SGTC_2480 5767542 37.17 µM -0.277203092131833 0.40398051493691 no 2034 0.390812082727862 2932 2867358 SGTC_303 1348-1668 34.2 µM -0.277475097344159 0.403881760353698 no 2035 0.390707662416867 2917 5380509 SGTC_2357 9067248 200 µM -0.279235655831453 0.40324271800729 no 2036 0.390031991025886 2979 9150235 SGTC_193 1273-0060 1.558 µM -0.279332254768028 0.403207662268933 no 2037 0.389994927645328 2881 2847393 YHR072W ERG7 SGTC_2223 6903751 107.57 µM -0.280538808583171 0.402769869706882 no 2038 0.389532077681964 2997 5598863 SGTC_1415 3966-0071 78.1 µM -0.281295441795787 0.402495390934886 no 2039 0.389241903074168 2942 2893185 SGTC_787 4152-0075 138 µM -0.283956285557821 0.401530516977783 no 2040 0.38822194065546 2920 9566539 SGTC_1300 1094-0077 113 µM -0.285357685369441 0.401022582870263 no 2041 0.387685061263437 2913 5532636 SGTC_1144 3486-0183 12.5 µM -0.285557174146486 0.400950292205683 no 2042 0.387608654098589 2920 6744069 SGTC_1646 st011709 75.6 µM -0.286154756019302 0.400733761026996 no 2043 0.387379797423007 3024 5757843 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.286684573178955 0.400541809598887 no 2044 0.38717692540863 2931 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2444 5485484 36.41 µM -0.287296342873178 0.400320196851896 no 2045 0.386942711324617 3039 6790631 SGTC_2673 kobusone 100 µM -0.287319068809241 0.400311965029932 no 2046 0.386934011564626 2928 6710676 An epoxy ketone and protein crosslinker. SGTC_1190 1486-1332 13 µM -0.287844303448084 0.400121726113438 no 2047 0.38673296130252 2959 4150046 SGTC_52 0329-0193 875 nM -0.28821471628374 0.39998757758569 no 2048 0.38659119228189 3128 3739292 SGTC_1012 4112-3522 18 µM -0.288426856823805 0.399910754187449 no 2049 0.386510006023031 3080 3112398 SGTC_1170 0310-0127 64.8 µM -0.292123746085352 0.398572607670917 no 2050 0.385096005700023 2993 774975 SGTC_1937 st074714 47.2 µM -0.292389135241234 0.398476591597577 no 2051 0.384994557146099 2870 17250970 SGTC_2153 5569715 200 µM -0.29300889119265 0.398252391860884 no 2052 0.384757677812679 2933 2054701 SGTC_2234 tolnaftate 200 µM -0.293197451964731 0.398184185742619 no 2053 0.384685615796501 2957 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_253 dyclonine 31.25 µM -0.293611342991625 0.398034484176264 no 2054 0.38452745359327 2935 3180 An oral anasthetic. SGTC_65 0798-0905 34.986 µM -0.293986763169552 0.397898710234908 no 2055 0.384384009065728 3325 3602145 SGTC_902 1120-0002 2.07 µM -0.294566286448707 0.397689144929202 no 2056 0.384162609745361 2919 3280475 SGTC_1410 3909-8106 77.9 µM -0.295007254276979 0.39752970336531 no 2057 0.383994169045132 3005 1039210 SGTC_3349 9149703 23.001 µM -0.295765737121067 0.397255497359882 no 2058 0.383704495369107 2887 4910494 SGTC_2984 9022109 38.96 µM -0.297549572024263 0.396610807392014 no 2059 0.383023483844088 3034 6459207 SGTC_3346 9158254 43.5805 µM -0.298898455319869 0.396123499362174 no 2060 0.382508762869335 3011 17639500 SGTC_685 1278-0033 54.9 µM -0.299042088274182 0.396071618954695 no 2061 0.382453966114632 3077 3590572 SGTC_2778 tioconazole 65.09 nM -0.299304201867538 0.395976947933474 no 2062 0.382353974417781 2885 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2387 9077560 195.08 µM -0.300158958419534 0.395668266897388 no 2063 0.382027954452428 2941 5303272 SGTC_179 1273-0063 6.77 µM -0.300294469417388 0.395619335370382 no 2064 0.381976275725355 2920 3108139 SGTC_1086 cerivastatin 2.18 µM -0.300651749492789 0.395490333364025 no 2065 0.381840032812515 2946 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_997 3996-0078 137 µM -0.301036152164489 0.395351551073303 no 2066 0.38169346348422 3005 735687 SGTC_132 0417-1715 25.805 µM -0.303256580883436 0.394550161891585 no 2067 0.380847166249156 3074 6769098 SGTC_129 0088-0017 176.636 µM -0.304325710352598 0.39416445439709 no 2068 0.380439879732628 3066 182446 SGTC_3311 9131146 2.8755 µM -0.304899478883775 0.393957499946269 no 2069 0.380221356333824 2971 4900406 YPR165W RHO1 SGTC_312 4092-0653 6.84 µM -0.305058863559081 0.393900016277208 no 2070 0.380160660446583 3044 1148278 SGTC_2566 crystal violet carbinol 226 nM -0.305946570912384 0.393579898111706 no 2071 0.379822663245885 3103 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1114 scopoletin 1.73284 µM -0.306202711467511 0.393487544043691 no 2072 0.37972515402384 3081 5280460 A coumarin with genotoxic properties. SGTC_2576 guaiol 23.12 µM -0.306926374012664 0.393226652588975 no 2073 0.37944970688863 3051 227829 SGTC_950 1165-0508 94.1 µM -0.306948371478931 0.393218722914983 no 2074 0.379441334966792 3028 6148369 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.307139876062144 0.393149690976666 no 2075 0.37936845344307 3001 688761 SGTC_3242 9133940 49.47 µM -0.307144045327429 0.393148188112846 no 2076 0.379366866779855 3094 17248444 SGTC_1176 0848-0131 83.3 µM -0.307312965208644 0.39308730016836 no 2077 0.379302584030252 3032 6769040 SGTC_2247 cerulenin 830 nM -0.308384851684121 0.392700994793087 no 2078 0.378894753637259 3171 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2909 7941780 10.49 µM -0.308421220275807 0.392687889489298 no 2079 0.378880918510342 3105 1243215 SGTC_2213 7173844 200 µM -0.308451468026924 0.392676989903185 no 2080 0.378869411955997 2985 892728 SGTC_3012 9080433 71.4286 µM -0.308715386872011 0.392581891985742 no 2081 0.37876901907993 3053 17688859 SGTC_2220 6782180 200 µM -0.309178255111142 0.392415122092713 no 2082 0.378592967006596 3007 833803 SGTC_508 roscovitine 141 µM -0.310934270158981 0.391782615569051 no 2083 0.377925295529901 2937 160355 A CDKinase inhibitor. SGTC_483 fpl-64176 144 µM -0.311028497516315 0.391748683485109 no 2084 0.377889478720738 2959 3423 SGTC_3345 9148410 3.559 µM -0.315020113159201 0.390312027678397 no 2085 0.376373191343503 3090 4903596 SGTC_1007 4101-0031 70 µM -0.315881473096911 0.390002204060132 no 2086 0.376046237404811 3115 1146276 SGTC_2359 9039622 200 µM -0.316907886337842 0.389633103458822 no 2087 0.375656748903116 2932 6463596 SGTC_273 hydroxyurea 18.1 mM -0.318116086887936 0.389198759258124 no 2088 0.375198440711951 2950 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2572 astragaloside iv 100 µM -0.318486682250304 0.389065559134624 no 2089 0.375057897587697 3141 45006101 An anti-inflammatory agent. SGTC_3122 9126309 49.47 µM -0.318585119577539 0.38903018078503 no 2090 0.375020569391164 3040 17591206 SGTC_2814 7977482 42.97 µM -0.318737575482487 0.388975389988812 no 2091 0.374962759242362 3118 6456762 SGTC_1550 gossypolone 36.6 µM -0.321014888769239 0.388157214707404 no 2092 0.37409955397593 2971 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2934 9036370 36.88 µM -0.321711192663042 0.387907150969826 no 2093 0.37383574888441 3072 6462800 SGTC_2173 5763948 167 µM -0.324141829754586 0.387034600771642 no 2094 0.372915329738161 2968 2867177 SGTC_2212 7123476 200 µM -0.327104147526363 0.38597195955292 no 2095 0.37179455747599 3001 1085715 SGTC_1265 0819-1001 68.8 µM -0.327112697210296 0.385968893847977 no 2096 0.371791324329456 2999 3106768 SGTC_888 0916-0002 6.97 µM -0.327120215374031 0.385966198026517 no 2097 0.371788481269838 3155 2802138 YIL048W NEO1 SGTC_984 1492-0255 2.91 µM -0.327356954196482 0.385881312349789 no 2098 0.371698959983111 3085 1585198 SGTC_1726 st035556 14.5795 µM -0.329499560253293 0.385113303022768 no 2099 0.370889063138884 3179 5919439 SGTC_2275 7947463 200 µM -0.330865443833795 0.384623941934039 no 2100 0.370373062519864 3126 1225414 SGTC_1016 4226-1401 38 µM -0.333447246125389 0.383699450893918 no 2101 0.369398352220867 3019 2901613 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.334841867907287 0.383200339986197 no 2102 0.368872187860705 3044 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_895 0964-0006 13.7 µM -0.335250127096709 0.383054267751159 no 2103 0.368718205848565 3127 6738897 SGTC_2978 9011784 42.97 µM -0.335485945796524 0.382969901072033 no 2104 0.368629272349095 3101 2994934 SGTC_1943 st076331 65.2 µM -0.337101207667786 0.382392173184064 no 2105 0.368020303535373 3112 24208415 SGTC_1085 doxorubicin 7.67 µM -0.337397846944731 0.382286103136848 no 2106 0.367908503744899 3102 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_868 0527-0199 213 µM -0.337413518090325 0.382280499811741 no 2107 0.367902597788915 3020 2849450 SGTC_634 1611-4317 11.2 µM -0.338422384646853 0.381919824612592 no 2108 0.36752245386935 3081 2843522 SGTC_2665 lovastatin 100 µM -0.338455616366748 0.381907945836189 no 2109 0.367509934264214 3021 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1581 himbacine 57.9 µM -0.339327505740724 0.381596326162284 no 2110 0.36718151197585 2994 5281825 An alkaloid muscarinic receptor antagonist. SGTC_185 k048-0037 25.491 µM -0.340377286604988 0.381221228580437 no 2111 0.366786210651215 3136 6827589 SGTC_198 3454-2873 16.191 µM -0.342348367026505 0.380517242749938 no 2112 0.366044370238579 3022 710957 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.3428453627881 0.380339799410377 no 2113 0.365857398654245 3154 16725076 SGTC_2697 mebhydrolin 72.4 µM -0.343487616682117 0.380110531579689 no 2114 0.365615827628854 3177 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_537 1334-0398 209 µM -0.345690420850953 0.379324508583177 no 2115 0.364787692001108 3174 5846986 SGTC_203 k066-0004 30.888 µM -0.347466848557954 0.378690991776723 no 2116 0.364120309933678 3094 6795412 SGTC_959 1222-0044 107 µM -0.347953661416917 0.378517439421227 no 2117 0.363937492134592 3159 6083612 SGTC_856 0433-0016 11.3 µM -0.348891169923529 0.378183279811922 no 2118 0.36358550727003 3106 3911780 SGTC_2589 lobaric acid 100 µM -0.348996250580057 0.378145831199762 no 2119 0.363546062209834 3028 73157 A novel microtubule depolymerizer. SGTC_882 0843-0131 351 µM -0.350681525440354 0.377545390093276 no 2120 0.362913643499913 3141 5425421 SGTC_422 cantharidin 155 µM -0.352012539440077 0.377071376441642 no 2121 0.362414429246066 2959 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3007 9078383 71.4286 µM -0.352435815070505 0.376920674183873 no 2122 0.362255723140343 3037 6496995 SGTC_2308 7584454 197.62 µM -0.354630771911975 0.376139487063592 no 2123 0.361433109975629 3209 893577 SGTC_402 epigallocatechin gallate 10 µM -0.354655790647484 0.376130585790672 no 2124 0.361423737282242 3036 65064 An antioxidant. SGTC_1771 st048882 4.1505 µM -0.357294254824657 0.375192232463253 no 2125 0.360435765258921 3014 4580403 SGTC_2693 st077581 40.7 µM -0.358002446410924 0.374940493959531 no 2126 0.360170741378591 3171 25238761 SGTC_443 clozapine 122 µM -0.359139648109551 0.374536368151119 no 2127 0.359745311262363 3101 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3234 9132280 49.47 µM -0.359584283117241 0.374378396259416 no 2128 0.359579019360905 3105 17612295 SGTC_3339 9145883 14.936 µM -0.361551899824851 0.37367958614871 no 2129 0.358843457275928 3171 2030670 SGTC_1642 st009582 77.7 µM -0.361626089843691 0.373653245253956 no 2130 0.358815732740127 3201 6739311 SGTC_1630 st005209 31.3 µM -0.361731215496835 0.373615921786113 no 2131 0.358776448945876 3148 3367314 SGTC_1571 st070080 73.4 µM -0.361831026585981 0.373580486280645 no 2132 0.358739152502603 3190 4315245 SGTC_1495 4469-0029 237 µM -0.362101351351659 0.373484519399637 no 2133 0.358638146921356 3052 793680 SGTC_2931 9014674 55.67 µM -0.36241770249538 0.373372222847087 no 2134 0.358519956354908 3003 2996810 SGTC_486 niguldipine 82 µM -0.363567605308656 0.372964127451384 no 2135 0.358090460412919 3047 1236 A calcium channel blocker. SGTC_107 0358-0022 2.6945 µM -0.366517369310704 0.371917921969289 no 2136 0.356989527072163 3129 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_356 1634-0012 32.5 µM -0.367085579677526 0.371716500669501 no 2137 0.356777591672729 3170 735457 SGTC_780 0109-0199 192 µM -0.369156894695991 0.370982550971948 no 2138 0.356005391622559 3223 610414 SGTC_1100 amiodarone 5.07 µM -0.369218869724385 0.370960597957081 no 2139 0.355982295998693 3145 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_848 0368-0089 85.6 µM -0.369253553225518 0.370948312427296 no 2140 0.355969371070315 3168 762535 SGTC_258 haloperidol 50.781 µM -0.369544338271423 0.370845316227013 no 2141 0.355861015515549 3090 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1028 k015-0029 4.8 µM -0.370117618714951 0.370642287134197 no 2142 0.355647427498432 3040 4588309 SGTC_3322 9139058 2.11 µM -0.370476792489652 0.370515102947873 no 2143 0.355513632632548 3228 4908926 YPR165W RHO1 SGTC_540 1187-0821 17.3 µM -0.370966673956748 0.370341657708648 no 2144 0.355331176894132 3073 847520 SGTC_2648 atorvastatin 78.68 µM -0.371238473249989 0.370245437034011 no 2145 0.35522995988618 3147 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_3163 9099914 49.47 µM -0.372082706721146 0.369946618615177 no 2146 0.354915635752904 3141 16268368 SGTC_813 k007-0158 173 µM -0.372427286320015 0.369824676406036 no 2147 0.354787370591928 3102 6523916 SGTC_1252 0493-0875 34.8 µM -0.372656735868039 0.36974348447337 no 2148 0.354701970185413 3037 3960963 SGTC_3021 9087658 49.47 µM -0.37266085331517 0.369742027546013 no 2149 0.354700437751107 3182 25237042 SGTC_1182 1222-0449 220 µM -0.373384787812086 0.369485897913272 no 2150 0.3544310398831 3127 658318 SGTC_1270 0831-1170 17.3 µM -0.375342403732721 0.368793579373567 no 2151 0.353702916931568 3084 6764716 SGTC_1033 k072-0102 21.3 µM -0.375917890919468 0.368590136915702 no 2152 0.353488969697572 3228 5965931 SGTC_924 2046-0044 21.3 µM -0.378485893902308 0.367682762885422 no 2153 0.352534835410525 3026 3623589 SGTC_1143 3454-2408 5.08 µM -0.378753042869086 0.367588411198522 no 2154 0.35243563010022 3142 X1143 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.379344878479974 0.367379415135194 no 2155 0.352215888720305 3124 676296 Flavone; oxidizing agent. SGTC_271 rotenone 740 µM -0.380199140291278 0.367077817275633 no 2156 0.351898798681182 3192 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_408 cantharidin 100 µM -0.380387386690365 0.367011367744733 no 2157 0.351828938088685 3091 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_536 3852-0578 10.6 µM -0.381433969224956 0.366642004856884 no 2158 0.351440629497534 3216 2869208 SGTC_980 1473-0395 201 µM -0.381551645281864 0.366600482003066 no 2159 0.351396978390039 3045 768876 SGTC_2375 9072683 200 µM -0.38238168053442 0.366307642387917 no 2160 0.351089138334055 3252 16798029 SGTC_1236 0330-0013 258 µM -0.384915625740709 0.365414138970036 no 2161 0.350149964272262 3085 4617066 SGTC_621 3584-0052 32.1 µM -0.385286977015019 0.365283256687339 no 2162 0.35001240451769 3201 2273927 SGTC_2640 pentamidine 10.38 µM -0.385696106491989 0.365139077689502 no 2163 0.349860873358954 3191 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2031 5180455 200 µM -0.386252394810448 0.364943069861644 no 2164 0.349654876666427 3071 29949 SGTC_136 0097-0015 404.482 µM -0.38831287164344 0.364217369964398 no 2165 0.3488922564898 3182 4861337 SGTC_347 4534-1311 26.2 µM -0.389776079863979 0.363702323326006 no 2166 0.348351066551703 3079 2862016 SGTC_115 0527-0192 112.043 µM -0.394462526559496 0.362054363766168 no 2167 0.346619794238263 3192 4233931 SGTC_1034 k072-0165 12.7 µM -0.394580428076799 0.362012937247482 no 2168 0.346576280028536 3234 5835461 SGTC_2539 epi(13)torulosol 80 µM -0.394714283322999 0.361965907099237 no 2169 0.346526880189673 3192 6708597 SGTC_200 k038-0079 37.545 µM -0.39537928414237 0.361732289438389 no 2170 0.346281497560656 3088 3436683 SGTC_2119 5528445 120.635 µM -0.395953390131344 0.361530644960854 no 2171 0.34606970664119 3242 791935 SGTC_1540 guanosine 70.6 µM -0.397021783139435 0.361155493392242 no 2172 0.345675698662149 3144 6802 Guanosine is a purine nucleoside SGTC_1611 st001856 99.4 µM -0.397690267055272 0.360920832294807 no 2173 0.345429256363887 3139 647478 SGTC_1706 st031321 9.9705 µM -0.398217174931599 0.360735906193075 no 2174 0.345235053442183 3202 6103185 SGTC_2722 naftopidil 47.16 µM -0.399644353114347 0.360235180565889 no 2175 0.344709241831942 3216 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1888 azatryptophan 97.5 µM -0.400188492575039 0.360044332234031 no 2176 0.344508844819853 3192 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2776 terbinafine 19.92 µM -0.40059602073229 0.359901421002694 no 2177 0.344358787926796 3176 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1680 diphenhydramine 100 µM -0.400597588118375 0.35990087139239 no 2178 0.344358210843184 3123 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1322 1348-1070 12 µM -0.401007963409841 0.359756981597159 no 2179 0.344207130447868 3222 6758089 SGTC_808 0711-0032 135 µM -0.402088029951483 0.359378373152231 no 2180 0.343809620897432 3210 4252555 SGTC_1202 1988-0068 29.6 µM -0.402265293713922 0.359316247973326 no 2181 0.343744396914436 3111 2850480 SGTC_867 0518-0118 155 µM -0.402329377499976 0.35929378960741 no 2182 0.343720818508798 3217 6848158 SGTC_2427 5545055 42.75 µM -0.402435696125918 0.359256530980331 no 2183 0.343681701941084 3096 5372858 SGTC_3154 9100113 49.47 µM -0.402507626066062 0.359231324389358 no 2184 0.343655238549206 3114 25237525 SGTC_2070 5230947 200 µM -0.402509748542295 0.359230580613946 no 2185 0.34365445769101 3227 2835538 SGTC_246 cycloheximide 667 µM -0.402792496006116 0.359131502714561 no 2186 0.343550440971979 3081 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1128 3448-9350 235 µM -0.40372736656615 0.358803981006858 no 2187 0.343206606542638 3168 619386 SGTC_1139 k015-0024 46.9 µM -0.404762785515204 0.35844135440469 no 2188 0.342825943038302 3237 2766652 SGTC_1819 st053448 58.6 µM -0.404796948675951 0.358429391883663 no 2189 0.342813385941491 3106 2857616 SGTC_2082 5219693 150 µM -0.40645336556152 0.357849550305311 no 2190 0.342204757765377 3098 2834649 SGTC_2292 7671323 168.05 µM -0.407747021177587 0.357396924045938 no 2191 0.341729706167385 3263 937504 SGTC_1098 clofazimine 15.1 µM -0.407929726743077 0.357333014882654 no 2192 0.341662633855357 3234 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3116 9124943 49.47 µM -0.408387453637927 0.357172922703368 no 2193 0.34149462151202 3136 41905195 YPL160W CDC60 SGTC_2545 solidagenone 89.61 µM -0.408863542322306 0.357006435073401 no 2194 0.341319902644871 3018 6708572 An anti ulcer agent SGTC_989 1501-0895 10.3 µM -0.409407173870897 0.356816361082256 no 2195 0.341120437939964 3255 2830112 SGTC_1198 1612-1005 86.7 µM -0.409615733215511 0.356743450339349 no 2196 0.341043926882134 3286 6998509 SGTC_1746 st038117 42 µM -0.411431761686879 0.356108802202669 no 2197 0.340377984125376 3199 2898218 SGTC_1629 st005085 44.9 µM -0.412914364898241 0.355590971634099 no 2198 0.339834678057544 3098 24207091 SGTC_2429 5902844 64.44 µM -0.417501969935039 0.353990344718829 no 2199 0.338155641855838 3233 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2732 terfenadine 20 µM -0.417967055653724 0.353828218540194 no 2200 0.337985602123799 3165 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2148 5546263 113.568 µM -0.418385006539557 0.353682545899982 no 2201 0.33783282352726 3113 792097 SGTC_146 3448-8650 53.125 µM -0.419731757409286 0.353213295055744 no 2202 0.337340711372127 3143 2891488 YIL048W NEO1 SGTC_561 1550-0330 72.9 µM -0.420294661185531 0.353017227541804 no 2203 0.337135104777329 3146 6812934 SGTC_1357 1503-1303 39.5 µM -0.420700842532932 0.352875772945631 no 2204 0.336986772924899 3153 292895 SGTC_1930 st074634 34.3 µM -0.421112210412498 0.352732532839558 no 2205 0.336836572854621 3099 684253 YOR116C RPO31 SGTC_1195 1502-0147 41.1 µM -0.421477015546556 0.35260552354976 no 2206 0.336703395701737 3154 817940 SGTC_2703 st077852 53.4 µM -0.422772637379389 0.352154577222596 no 2207 0.33623057664877 3247 6281836 SGTC_1877 wortmannin 25 µM -0.42338913333155 0.351940076283787 no 2208 0.336005685951836 3273 312145 A covalent inhibitor of PI 3-kinase. SGTC_1743 st037606 46.3785 µM -0.424394280073879 0.351590450914021 no 2209 0.335639145765278 3140 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1217 1183-1422 255 µM -0.427381130311063 0.350552260961822 no 2210 0.33455087455279 3278 2849664 SGTC_216 k038-0035 28.382 µM -0.427404191535343 0.350544249511892 no 2211 0.33454247749125 3215 4444231 YPR107C YTH1 SGTC_1354 1498-1681 81 µM -0.431153418008855 0.349242657601267 no 2212 0.333178410887588 3244 5754243 SGTC_1931 st074438 57.1 µM -0.432414290240716 0.348805326890176 no 2213 0.332720166897129 3218 2787313 SGTC_3281 9140613 49.47 µM -0.435896458234659 0.347598589266966 no 2214 0.331455927468862 3203 16013766 SGTC_1089 terbinafine 2.25 µM -0.437239554089689 0.347133553937964 no 2215 0.330968813478695 3269 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2293 7624732 200 µM -0.437510654562963 0.347039715629447 no 2216 0.330870525426484 3166 894453 SGTC_412 gemfibrozil 100 µM -0.439101744301254 0.346489167448687 no 2217 0.330293907629685 3249 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1462 k081-0014 26.5 µM -0.44046468517958 0.346017820914428 no 2218 0.329800292155868 3155 3270634 SGTC_3201 9113999 49.47 µM -0.440714827827135 0.345931339835473 no 2219 0.329709730296758 3311 16649224 SGTC_2241 6772625 37.8075 µM -0.441101088042573 0.345797815018757 no 2220 0.329569907927821 3263 2285411 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.4417218200129 0.345583276735219 no 2221 0.329345259014796 3298 1377 SGTC_2468 5987765 72.9 µM -0.442900813109967 0.345175928015314 no 2222 0.328918739630564 3198 26772094 SGTC_1856 st057054 55.7 µM -0.442930538523971 0.34516566003383 no 2223 0.328907988867991 3372 1266018 SGTC_2242 6630449 61.2675 µM -0.443960246303726 0.344810040850813 no 2224 0.328535662852845 3292 691249 YDR170C SEC7 SGTC_1965 Pectolinarigenin 58.4 µM -0.44505076070424 0.344433570977344 no 2225 0.328141535673791 3186 5320438 An anti-inflammatory. SGTC_294 k038-0071 157 µM -0.445214026045971 0.344377221393378 no 2226 0.328082545741941 3241 24152826 SGTC_1967 st070177 51.4 µM -0.445261811698154 0.344360729252938 no 2227 0.328065280963543 3330 5729214 SGTC_1972 st070201 17.4 µM -0.445752242575775 0.344191485201928 no 2228 0.327888111348652 3302 2829099 SGTC_1793 st048256 72.231 µM -0.447194783482543 0.34369385602322 no 2229 0.32736721376045 3225 672022 SGTC_3297 9117502 71.43 µM -0.447199346076921 0.343692282507238 no 2230 0.327365566752524 3279 7453720 SGTC_230 MPP+ 141.667 µM -0.447643569391485 0.343539094814822 no 2231 0.327205226862212 3241 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1282 0886-0010 32.4 µM -0.447700842952062 0.34351934624721 no 2232 0.327184556614436 3364 2836211 YNL267W PIK1 SGTC_2593 nobiletin 86.24 µM -0.448625923728132 0.343200427195214 no 2233 0.326850764866815 3224 72344 An anti-infammatory. SGTC_2179 6298986 200 µM -0.450146031714128 0.342676616680759 no 2234 0.326302573647626 3293 738374 SGTC_2552 juarezic acid 87.02 µM -0.450298052969536 0.342624248640381 no 2235 0.326247771363644 3182 1549512 SGTC_611 3453-1652 23.7 µM -0.45080290013385 0.342450361396701 no 2236 0.32606580545927 3304 1560575 SGTC_3003 9075612 71.4286 µM -0.451372019377636 0.342254376608966 no 2237 0.325860723133565 3245 6501993 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.451685790782179 0.34214634285978 no 2238 0.325747678017388 3247 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3184 9108758 49.47 µM -0.452222437420908 0.341961601513836 no 2239 0.325554372863964 3211 902885 SGTC_2264 7948757 110.76 µM -0.45338084627206 0.341562946685908 no 2240 0.325137263095302 3123 2971411 SGTC_801 0866-0028 10.1 µM -0.454015428698539 0.341344636357869 no 2241 0.324908861002647 3156 6849771 SGTC_3306 9127676 59.7925 µM -0.454061919470684 0.341328644594564 no 2242 0.324892130396385 3265 41905287 SGTC_3076 9116187 49.47 µM -0.454279825643955 0.341253693647926 no 2243 0.324813717340174 3273 27241210 SGTC_2268 7933382 153.85 µM -0.454430647253462 0.341201820755989 no 2244 0.324759449061486 3286 935025 YOR257W CDC31 SGTC_3123 9126162 49.47 µM -0.455326543601054 0.340893752160621 no 2245 0.324437166431069 3163 25239884 SGTC_1716 st033144 30.6155 µM -0.456000951166355 0.340661916061913 no 2246 0.324194647117476 3373 674617 SGTC_1064 honokiol 6.76 µM -0.45733731725102 0.340202701222759 no 2247 0.323714305578283 3272 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1747 st037496 66.6 µM -0.457596643623886 0.340113616451234 no 2248 0.323621127652969 3191 723305 SGTC_1617 st002906 78 µM -0.458087384261303 0.339945059808831 no 2249 0.32344483109617 3225 5150859 SGTC_1499 4480-0877 67.3 µM -0.458290099212279 0.339875441831534 no 2250 0.323372018146914 3271 2861909 SGTC_2912 7964298 10.93 µM -0.460590590633646 0.339085771927326 no 2251 0.32254618180706 3297 2975850 SGTC_1340 1486-1359 257 µM -0.460792353652562 0.3390165481163 no 2252 0.322473794064441 3218 4309068 SGTC_363 0455-0021 3.06 µM -0.46229566396366 0.338500941649316 no 2253 0.321934654329267 3214 4597466 SGTC_3294 9122953 26.2835 µM -0.462321626282324 0.338492039729723 no 2254 0.321925346619818 3220 16459826 SGTC_2435 5706476 10.6 µM -0.463215575994653 0.33818557872006 no 2255 0.321604926318716 3344 5725375 SGTC_1859 st055998 20 µM -0.464134528205369 0.337870658149043 no 2256 0.32127568259377 3371 676301 SGTC_2048 5246248 200 µM -0.464232550072081 0.337837073212069 no 2257 0.321240571439306 3322 677046 SGTC_3225 9130819 49.47 µM -0.464474070273818 0.337754327382658 no 2258 0.32115406640717 3323 4547121 SGTC_3085 9117376 49.47 µM -0.468960964719451 0.336218528317848 no 2259 0.319548769076247 3321 16480349 SGTC_3337 9144342 33.5465 µM -0.469296854007054 0.336103667775656 no 2260 0.319428731827503 3321 17682949 SGTC_2446 5162541 200 µM -0.469925674722539 0.33588867768336 no 2261 0.319204060117699 3189 1549321 SGTC_2121 5257820 149.641 µM -0.470537872148772 0.335679422572221 no 2262 0.318985391523181 3344 791256 SGTC_2001 4023502 57.655 µM -0.471422435864246 0.33537715997625 no 2263 0.318669548655646 3300 108941 YCR052W RSC6 SGTC_910 3454-3003 490 µM -0.47223715403611 0.335098858405591 no 2264 0.318378761370894 3351 820824 SGTC_853 0419-0306 21 µM -0.47369077535924 0.33460253721544 no 2265 0.317860216207065 3216 762713 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.473889525940011 0.334534698694796 no 2266 0.31778934433785 3207 4000243 SGTC_741 4582-0002 126 µM -0.474173799181765 0.33443767855008 no 2267 0.317687987802875 3222 2912688 SGTC_1101 ebselen 5.29 µM -0.474982159463845 0.334161852202887 no 2268 0.317399844720872 3377 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_393 acivicin 6.25 µM -0.47514000112999 0.334108004372005 no 2269 0.317343594364951 3181 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2675 theaflavin digallate 100 µM -0.475267958679399 0.334064354041294 no 2270 0.317297996968538 3310 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2728 chlorpromazine 9.18 µM -0.477263712989156 0.333383830528829 no 2271 0.316587173492559 3251 2726 A thorazine and dopamine antagonist. SGTC_3351 9150312 21.596 µM -0.47768952933267 0.333238704144003 no 2272 0.316435598934866 3321 4904905 SGTC_1679 SEC14.276 6.7 µM -0.478077237869136 0.333106587343416 no 2273 0.316297616132002 3329 1005053 YMR079W SEC14 SGTC_1421 4029-0249 71.4 µM -0.479509801172266 0.332618602233232 no 2274 0.315787998643381 3390 2894095 SGTC_3176 9106582 49.47 µM -0.480944734182489 0.332130094072186 no 2275 0.315277888978995 3273 17018027 SGTC_1678 st019265 80.2 µM -0.481340289476977 0.331995481446674 no 2276 0.31513733340009 3423 5367020 SGTC_1186 1319-0216 26 µM -0.481341201621576 0.33199517105702 no 2277 0.315137009311943 3395 4565136 SGTC_1479 0549-0158 134 µM -0.482159467526049 0.331716773432012 no 2278 0.314846333934426 3297 5440202 SGTC_3131 9127911 49.47 µM -0.482337188779236 0.331656319820284 no 2279 0.314783216560557 3436 45595681 SGTC_1258 0671-0043 57.1 µM -0.483022158291516 0.331423361806582 no 2280 0.314540001530883 3292 4298767 SGTC_1963 st076565 50.3 µM -0.483775563325063 0.331167204187811 no 2281 0.314272579728596 3227 4914280 SGTC_1700 st030840 7.9285 µM -0.484312076775232 0.330984837826431 no 2282 0.314082203192549 3329 5499307 SGTC_1435 4092-0789 56.7 µM -0.484386379249205 0.330959584822066 no 2283 0.314055841586705 3335 2248285 SGTC_1232 0279-0259 161 µM -0.486121953701402 0.330369938275415 no 2284 0.313440351215436 3283 1560000 SGTC_768 0384-0033 77.3 µM -0.486899553391392 0.330105891894193 no 2285 0.3131647577178 3246 3965305 YMR134W ERG29 SGTC_1909 st060837 51.5 µM -0.48763823520155 0.32985513905056 no 2286 0.31290305394606 3261 678937 SGTC_2694 st077685 81.9 µM -0.488092193490953 0.329701076336856 no 2287 0.312742270155478 3184 2838096 SGTC_3134 9127454 49.47 µM -0.489219177148559 0.329318729661558 no 2288 0.312343267029953 3399 24262820 SGTC_128 0906-2981 13.371 µM -0.490007555349595 0.329051366169579 no 2289 0.312064276246189 3384 6740226 SGTC_421 streptovitacin 30 mM -0.49011194022599 0.329015972572835 no 2290 0.312027344666946 3397 91467 include heat shock SGTC_2373 9071805 200 µM -0.490955115251021 0.328730134919997 no 2291 0.311729096942441 3394 10149009 SGTC_92 0063-0024 660.874 µM -0.491100996757253 0.328680691020677 no 2292 0.311677508282422 3328 3594437 SGTC_874 0599-0792 117 µM -0.491646643827715 0.328495780402351 no 2293 0.311484581699455 3419 765305 SGTC_62 0180-0423 3.232 µM -0.492100545344785 0.328341992804232 no 2294 0.311324133379684 3294 30102 YGL099W LSG1 SGTC_840 0245-0196 390 µM -0.492521409924411 0.328199424523374 no 2295 0.311175395206956 3416 3827528 SGTC_3286 9117135 37.221 µM -0.492609656305553 0.328169534149472 no 2296 0.311144211873985 3239 3438150 SGTC_1383 3049-0032 20.7 µM -0.492622648588373 0.328165133561171 no 2297 0.311139620948283 3384 712864 SGTC_2514 salinomycin 42.74 µM -0.492992028273817 0.328040031737898 no 2298 0.311009110015553 3393 23682228 A polyether potassium ionophore. SGTC_1048 3161-0300 24.5 µM -0.496294099190998 0.32692254192029 no 2299 0.309843464451601 3363 2165101 SGTC_2465 5809242 33.21 µM -0.496508198926668 0.326850139510248 no 2300 0.309767952089752 3321 2731748 SGTC_2380 9035439 200 µM -0.496754891231935 0.326766723307554 no 2301 0.309680954374964 3407 6462575 SGTC_2016 5121758 140 µM -0.50042859271556 0.325525529267686 no 2302 0.308386662262869 3348 2795203 SGTC_222 nsc-310342 10.666 µM -0.50077613163289 0.325408209862299 no 2303 0.308264342728914 3355 432556 SGTC_890 0929-0006 47.2 µM -0.501053934836976 0.325314443720006 no 2304 0.308166582631375 3282 1378169 SGTC_1976 st070609 63.5 µM -0.501094721261708 0.325300678122363 no 2305 0.308152230865035 3316 682556 SGTC_1892 st058411 7.36 µM -0.502015479691631 0.324989981566147 no 2306 0.307828316106017 3366 3934738 SGTC_121 0557-0495 61.343 µM -0.50202623099136 0.324986354414487 no 2307 0.307824534776584 3331 3104427 SGTC_1422 4031-0024 15.5 µM -0.505469673336191 0.323825499932609 no 2308 0.306614496792244 3328 782427 SGTC_479 n-linoleoylglycine 10 µM -0.505636944618761 0.323769152883991 no 2309 0.30655577057062 3314 6433346 An anti-infammatory. SGTC_111 0083-0039 52.457 µM -0.5070938680837 0.323278544176034 no 2310 0.306044478642872 3313 759313 SGTC_1801 st050089 28.441 µM -0.508743798688077 0.32272331257945 no 2311 0.305465908886955 3377 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2522 biochanin a 4.94 µM -0.510102659037261 0.322266327947683 no 2312 0.304989771211929 3408 5280373 A possible chelator. SGTC_722 3534-0461 190 µM -0.511099325162924 0.32193131984721 no 2313 0.304640754228362 3349 658262 SGTC_1165 k072-0275 30.3 µM -0.511193752625282 0.321899587564468 no 2314 0.304607696412641 3423 6153523 YGL055W OLE1 SGTC_1448 4255-0083 152 µM -0.51197755317102 0.32163624208744 no 2315 0.304333359738511 3419 5399660 SGTC_2371 9071574 200 µM -0.512348465590467 0.321511652182944 no 2316 0.304203575683103 3380 45596039 SGTC_2521 angolensin 13.4 µM -0.515470633915119 0.320463709142988 no 2317 0.303112092607207 3415 821428 A flavenoid. SGTC_1913 st060213 96.1 µM -0.516070349590458 0.320262580468231 no 2318 0.302902637899391 3449 688959 SGTC_1677 st019204 53.9 µM -0.519262728605159 0.31919283116856 no 2319 0.30178877034269 3346 3945625 SGTC_2832 7992762 51.95 µM -0.519751242691078 0.319029265127094 no 2320 0.301618483212812 3181 2985177 SGTC_2607 solasodine 47.35 µM -0.520848179532458 0.31866211320391 no 2321 0.301236268540482 3313 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2141 5621638 7.665 µM -0.522606398304849 0.318073997197016 no 2322 0.300624093530619 3414 2856238 SGTC_3064 1327-0027 10 µM -0.523868253236039 0.317652195052427 no 2323 0.300185088508 3337 16000455 YPR107C YTH1 SGTC_594 1487-1584 10.8 µM -0.524222360989815 0.317533869408121 no 2324 0.300061944929797 3296 5013332 SGTC_3204 9114183 49.47 µM -0.524362957016838 0.317486894200798 no 2325 0.300013057965032 3303 17027248 SGTC_447 ml7 120 µM -0.52617032380729 0.316883288232808 no 2326 0.299384935535115 3420 4216 Selective myosin light chain kinase inhibitor. SGTC_885 0865-0106 16.8 µM -0.526457284478491 0.316787496793945 no 2327 0.299285261668109 3353 2793380 SGTC_806 3966-4455 5.86 µM -0.527234146383788 0.31652823119984 no 2328 0.299015499462436 3314 714982 SGTC_3165 9101544 49.47 µM -0.527284390369549 0.316511466151736 no 2329 0.298998056240384 3407 5002184 SGTC_56 0957-0365 83.25 µM -0.527698636388744 0.316373257920134 no 2330 0.298854259919518 3415 6752360 SGTC_326 k292-0812 17.5 µM -0.528828409279084 0.315996453086223 no 2331 0.29846224411243 3376 3579357 SGTC_1934 st074720 32.6 µM -0.529056146997856 0.315920520529993 no 2332 0.298383250569903 3347 17250992 SGTC_3053 9095903 49.47 µM -0.529472374115389 0.315781761704736 no 2333 0.298238901826662 3429 17174018 SGTC_3256 9138902 49.47 µM -0.530768411507907 0.315349864338191 no 2334 0.297789636190638 3370 17228773 SGTC_3171 9103192 49.47 µM -0.531439883136198 0.315126199231455 no 2335 0.297556994977384 3446 13018434 SGTC_3191 9110352 49.47 µM -0.532246777612218 0.314857514834798 no 2336 0.297277544335628 3402 17122424 SGTC_1197 1601-0112 267 µM -0.534279084623085 0.314181219824723 no 2337 0.29657423026331 3324 7350313 SGTC_3319 9138450 16.7555 µM -0.535459546451081 0.313788681155702 no 2338 0.296166061855475 3320 2029690 SGTC_1795 st049545 62.3 µM -0.535797635281594 0.313676295355582 no 2339 0.296049208340357 3398 5291882 SGTC_2249 haloperidol 116.36 µM -0.536463429549672 0.313455025906928 no 2340 0.295819152009485 3423 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_524 r073-0010 27.8 µM -0.539844732607758 0.312332324105251 no 2341 0.294652057451899 3342 2772106 SGTC_2358 9037157 4 µM -0.540199792403953 0.312214533566062 no 2342 0.294529627914896 3398 2388925 SGTC_1790 st045711 43.5 µM -0.543094729251497 0.311254859767445 no 2343 0.293532290724379 3487 585119 SGTC_960 1222-0186 7.7 µM -0.546293007818436 0.310196117757981 no 2344 0.292432270925021 3447 3126296 SGTC_2953 9074162 66.49 µM -0.546316709570015 0.31018827750487 no 2345 0.292424126074259 3415 16451992 SGTC_1469 k284-2957 126 µM -0.546954084878251 0.309977473818043 no 2346 0.292205138500112 3404 23884841 SGTC_2060 5238662 140 µM -0.548131488481418 0.309588226990661 no 2347 0.291800810337637 3389 790130 SGTC_1054 3429-0080 167 µM -0.548417247326272 0.309493787973879 no 2348 0.291702718189059 3483 1162877 SGTC_1071 trifluoperazine 6.31 µM -0.549235429885387 0.309223460481776 no 2349 0.291421946523359 3490 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2224 6650123 117.647 µM -0.550002985102215 0.308969954114253 no 2350 0.291158663066725 3403 2908370 SGTC_24 0417-1663 219 µM -0.550162240024894 0.308917367156079 no 2351 0.291104050051341 3437 4329390 SGTC_1827 berberine 7.24 µM -0.5506979176129 0.30874051185893 no 2352 0.290920386182389 3316 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_906 1165-0455 526 µM -0.551315140631214 0.308536789120951 no 2353 0.290708830598339 3425 3252859 SGTC_342 k048-0088 23.3 µM -0.55173362920587 0.308398694869754 no 2354 0.290565432957417 3354 6820570 SGTC_2090 5301565 104.445 µM -0.554555478069732 0.307468240162034 no 2355 0.289599374485319 3406 2056344 SGTC_1349 flufenamic acid 69 µM -0.554863227110436 0.307366840100771 no 2356 0.289494108022246 3402 3371 A non-steroidal anti-inflammatory. SGTC_2071 5230951 39.92 µM -0.554867766533319 0.307365344518998 no 2357 0.289492555433817 3494 1799272 SGTC_2623 humulene 100 µM -0.5558387094022 0.307045526299694 no 2358 0.289160560250966 3421 6187145 An anti-inflammatory. SGTC_968 1309-0633 340 µM -0.555865893567139 0.307036574236649 no 2359 0.289151267726941 3438 3761976 SGTC_1443 4112-3303 14 µM -0.557413249944744 0.306527201463651 no 2360 0.288622557354152 3433 704433 SGTC_2294 7971431 200 µM -0.557600235118487 0.306465673270525 no 2361 0.288558697946551 3409 5741572 SGTC_2158 5657123 3.6195 µM -0.559393319439598 0.305875929151889 no 2362 0.287946659837693 3431 2858827 SGTC_2630 antimycin a 100 µM -0.562108171857336 0.304983973741605 no 2363 0.287021160487712 3414 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_8 0354-0001 70 µM -0.563758677245299 0.30444227120353 no 2364 0.286459188960801 3482 4993152 SGTC_378 3970-0959 8.33 µM -0.564192186291824 0.304300062822354 no 2365 0.286311672468431 3458 6615653 SGTC_2529 gangaleoidin 93.61 µM -0.564442450963048 0.30421797942726 no 2366 0.286226527655389 3415 4565183 SGTC_1988 st071872 53.4 µM -0.565203430732672 0.30396844906683 no 2367 0.285967701726457 3493 16414116 SGTC_2073 5212005 126 µM -0.566534764223168 0.303532115543722 no 2368 0.285515153723133 3368 691789 SGTC_661 1304-0007 33.6 µM -0.567943021284448 0.303070875639379 no 2369 0.285036829151598 3429 3117130 SGTC_1408 3909-7976 48.8 µM -0.568020781199916 0.303045416431907 no 2370 0.285010428575821 3463 24152374 SGTC_762 1165-0429 115 µM -0.57167606758447 0.301849728379279 no 2371 0.283770725467979 3468 5967793 SGTC_1492 4158-0558 28.5 µM -0.573064273063497 0.30139618584458 no 2372 0.283300588169427 3466 3967268 SGTC_3147 9097027 49.47 µM -0.573277547691694 0.301326533788882 no 2373 0.283228392527081 3414 25236841 SGTC_2520 obtusaquinone 4.71 µM -0.574432368779314 0.300949513775382 no 2374 0.282837627126483 3563 5967872 SGTC_929 2805-0021 398 µM -0.576187398224765 0.300376948480738 no 2375 0.282244261034856 3472 3098024 SGTC_707 0865-0008 204 µM -0.577765440144384 0.299862544707791 no 2376 0.281711245500159 3465 723043 SGTC_2103 5378138 10 µM -0.577848058142999 0.299835624213269 no 2377 0.281683352975916 3540 244142 SGTC_1097 itavastatin 7.23 µM -0.578053389729073 0.299768723097724 no 2378 0.281614037090174 3492 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1179 1021-1431 9.29 µM -0.579153006140363 0.299410561289557 no 2379 0.281242968366705 3439 2840958 SGTC_2863 9028737 58.44 µM -0.580441754282351 0.298991043553114 no 2380 0.280808377299557 3421 6460917 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.58296909477189 0.298169111034354 no 2381 0.27995705266574 3500 5377381 SGTC_1053 3366-3204 134 µM -0.584543105276296 0.297657737693528 no 2382 0.279427486609566 3446 3632071 YPR165W RHO1 SGTC_2540 epiandrosterone 100 µM -0.586104132971308 0.297150977928969 no 2383 0.278902769544995 3574 441302 A steroid. SGTC_2906 7926292 26.41 µM -0.587542918071857 0.296684251649062 no 2384 0.27841956751803 3510 2966319 SGTC_2868 9035608 32.47 µM -0.587629740685599 0.296656098078083 no 2385 0.278390422041139 3499 6462614 SGTC_1018 4259-0013 28.1 µM -0.588210528897376 0.296467800022884 no 2386 0.278195495537729 3490 6801262 SGTC_2723 salbutamol 83.58 µM -0.588793249499025 0.296278930532696 no 2387 0.277999987391006 3492 9884233 β2-adrenoceptor agonist SGTC_521 r062-0005 13.8 µM -0.589716399464743 0.295979835199963 no 2388 0.277690399348914 3453 2832033 SGTC_2436 5633522 8.09 µM -0.589914000333655 0.295915831659128 no 2389 0.277624153708121 3538 5724242 SGTC_2684 capsaicin 100 µM -0.592719230296959 0.295007895249699 no 2390 0.276684534794774 3519 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_948 3448-0295 75.3 µM -0.593411658907515 0.294783982511596 no 2391 0.276452844096204 3525 678569 SGTC_2580 diallyl disulphide 81.36 µM -0.593517157446019 0.294749874009298 no 2392 0.276417552016619 3460 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2968 9090663 33.37 µM -0.597241066906693 0.29354707258601 no 2393 0.275173222309686 3410 25236811 SGTC_168 3970-0862 530.542 µM -0.598145156689696 0.293255400017791 no 2394 0.274871540880639 3510 3135186 SGTC_2093 5331342 194.4 µM -0.598175872257719 0.293245493086938 no 2395 0.274861294412299 3533 33839 SGTC_3017 9080681 49.47 µM -0.598410980999452 0.293169666776626 no 2396 0.274782870248543 3492 16451914 SGTC_2474 5321570 43.32 µM -0.603794368645177 0.291435931473913 no 2397 0.272990181955925 3492 2841384 SGTC_375 3970-0961 9.27 µM -0.605391206003738 0.290922586778544 no 2398 0.272459546383512 3456 2898222 SGTC_3054 9094397 49.47 µM -0.606113945628494 0.290690382416829 no 2399 0.272219545552227 3474 2598354 SGTC_3120 9124077 49.47 µM -0.606609157851459 0.290531328932097 no 2400 0.272055160640832 3539 18774327 YGL155W CDC43 SGTC_941 3237-0776 460 µM -0.60779853670167 0.290149487759285 no 2401 0.27166054996473 3565 760008 SGTC_1957 st077035 62.4 µM -0.607850322847371 0.290132867548749 no 2402 0.271643374895757 3585 705593 SGTC_1337 1486-1011 40.3 µM -0.607902372070435 0.290116163355895 no 2403 0.271626113120951 3554 X1337 SGTC_1978 st071761 42 µM -0.609514435382775 0.289599026066077 no 2404 0.271091753726343 3456 5147680 SGTC_2489 cantharidin 73.42 µM -0.613328722159328 0.288377159214845 no 2405 0.269829502759696 3551 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_769 0302-0231 76 µM -0.613996789076069 0.28816340134678 no 2406 0.26960872450847 3565 571869 YER009W NTF2 SGTC_1886 st057356 49.9 µM -0.614532800423784 0.287991950674419 no 2407 0.269431652554024 3467 24207747 SGTC_496 calpeptin 138 µM -0.615330443921517 0.287736902511851 no 2408 0.269168258094858 3502 73364 A calpain inhibitor. SGTC_2841 9004761 38.96 µM -0.615513758987986 0.287678302224186 no 2409 0.269107742830806 3428 2991039 SGTC_2416 tofa 880 nM -0.616153322958781 0.287473897123871 no 2410 0.268896665908094 3428 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1297 1068-0111 14.1 µM -0.616872585387665 0.287244102426416 no 2411 0.268659385256443 3498 767057 SGTC_469 w7 172 µM -0.616907894542121 0.287232823864155 no 2412 0.268647739673681 3551 45115570 A P450 inhibitor. SGTC_1135 dihydrocapsaicin 536.708 nM -0.617278144853951 0.287114569957379 no 2413 0.26852563985927 3523 107982 A Capsaicinoid. SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.619434367675951 0.286426354359631 no 2414 0.267815123200558 3522 75037 A free radical scavenger. SGTC_1940 st075990 51.1 µM -0.619819022377055 0.28630366396567 no 2415 0.267688471741851 3654 1084979 SGTC_2231 micatex 6.853 µM -0.622075705261337 0.285584369997856 no 2416 0.266946044566263 3555 20737 An antifungal of unknown mechanism. SGTC_3195 9113082 49.47 µM -0.623266505404931 0.285205161931639 no 2417 0.266554702304198 3533 17018038 SGTC_1392 3455-1037 33.9 µM -0.624554499265319 0.284795273029253 no 2418 0.266131745351587 3589 981132 SGTC_2787 5284540 71.43 µM -0.624838510140413 0.284704927748334 no 2419 0.2660385263917 3536 736958 SGTC_209 4077-0173 175.592 µM -0.625472739952376 0.28450322547111 no 2420 0.265830417169832 3502 15993494 SGTC_681 1642-0006 26.6 µM -0.626341096063446 0.284227175434771 no 2421 0.265545618186602 3571 4446530 SGTC_2807 7945238 51.95 µM -0.627590929871263 0.283830078746082 no 2422 0.265135975983106 3563 17148797 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.627758049007996 0.283777001859492 no 2423 0.26508122579604 3522 803109 SGTC_1653 st012112 65 µM -0.62942931279876 0.283246471568422 no 2424 0.264534016273361 3578 720429 SGTC_2086 5274770 176.623 µM -0.629565968638065 0.283203112235501 no 2425 0.264489297496841 3539 689278 SGTC_1924 st058459 75.1 µM -0.633007792308016 0.282112112361588 no 2426 0.263364277202723 3554 688683 SGTC_2256 7954252 200 µM -0.63340522154291 0.281986264454718 no 2427 0.263234528033974 3520 2972920 SGTC_562 3772-2733 112 µM -0.638636377089251 0.280332318819265 no 2428 0.261529755384068 3588 2876874 YIL048W NEO1 SGTC_1938 st074717 56.4 µM -0.640982054910695 0.279592209506468 no 2429 0.260767171050538 3497 17250979 SGTC_476 mead acid 10 µM -0.641058680587388 0.279568048546812 no 2430 0.260742279208118 3597 5312531 An omega 9 fatty acid. SGTC_2892 9047358 58.44 µM -0.641873804897115 0.279311093212609 no 2431 0.260477561869736 3547 6466771 SGTC_379 3970-0972 5.9 µM -0.642867245556927 0.278998081643451 no 2432 0.260155122270796 3563 2898042 YBL034C STU1 SGTC_2068 5226020 147 µM -0.643823098107539 0.278697074412865 no 2433 0.259845076912203 3581 1810509 SGTC_2343 7990716 14.84 µM -0.644641364281832 0.278439520137371 no 2434 0.259579811323202 3569 6456862 SGTC_2326 6164455 177.58 µM -0.645078606253697 0.278301943116024 no 2435 0.25943812352753 3557 2888790 SGTC_2138 5575593 77.673 µM -0.645439644792353 0.278188368285172 no 2436 0.259321159491638 3584 762213 SGTC_1460 k062-0059 9.15 µM -0.645529278527148 0.278160174974607 no 2437 0.259292125475148 3520 1373085 SGTC_338 4055-0136 114 µM -0.646047193990157 0.277997297626026 no 2438 0.25912439602469 3555 2900563 SGTC_925 2064-1272 59.6 µM -0.647186676889039 0.277639109712176 no 2439 0.258755566499577 3538 6815817 SGTC_2457 5731572 11.68 µM -0.647240571072225 0.277622174064874 no 2440 0.258738128681809 3621 2865357 SGTC_651 3253-0966 34.4 µM -0.647334077135811 0.277592792022469 no 2441 0.258707875622547 3583 781462 SGTC_1478 0453-0656 35.7 µM -0.64816021891832 0.277333262773378 no 2442 0.258440664337636 3605 5258496 SGTC_3276 9139060 49.47 µM -0.648545597116083 0.277212238298432 no 2443 0.258316064674784 3641 4870619 SGTC_2229 7354935 190 µM -0.649258524095234 0.276988418273201 no 2444 0.258085644724686 3550 318112 SGTC_1612 st002233 45.4 µM -0.649883058762104 0.276792421313553 no 2445 0.257883881028798 3617 1035021 SGTC_2197 6588183 93.1375 µM -0.650751981124615 0.276519841522174 no 2446 0.257603301056556 3580 884136 SGTC_3334 9142812 21.919 µM -0.651813854741592 0.27618691196584 no 2447 0.257260631390587 3594 45283678 SGTC_1261 0712-0010 12.7 µM -0.653565964316049 0.275638003003055 no 2448 0.256695739060701 3623 2840123 SGTC_1127 asiatic acid 681.4 nM -0.656451768571453 0.274735095793127 no 2449 0.255766745439413 3585 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1810 st050138 53 µM -0.657065026148463 0.274543408498014 no 2450 0.25556955288199 3608 3444541 SGTC_1425 4048-4433 7.33 µM -0.657391673365043 0.274441334585624 no 2451 0.255464552115236 3659 23734946 SGTC_3239 9133757 49.47 µM -0.657669170967453 0.274354634141476 no 2452 0.255375368206308 3601 17036923 SGTC_2585 alliin 100 µM -0.657868977772223 0.274292215530323 no 2453 0.255311163127817 3683 87310 A garlic compound which reacts with lipids. SGTC_1077 5-fluorocytosine 377 nM -0.659739829529636 0.27370811155069 no 2454 0.254710401124773 3591 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3143 9086658 49.47 µM -0.659872661323401 0.27366666316186 no 2455 0.254667774760355 3653 25236626 SGTC_1019 4262-0212 3.4 µM -0.665556278956815 0.271896080677421 no 2456 0.252847379934625 3664 4677213 SGTC_3237 9133362 49.47 µM -0.668206417625523 0.271072451815712 no 2457 0.25200091973459 3578 43845137 SGTC_2438 5259590 200 µM -0.670309822392004 0.27041962775005 no 2458 0.251330153443027 3632 1201127 SGTC_169 k015-0017 16.025 µM -0.671362166438343 0.270093311712157 no 2459 0.25099492026088 3676 1840002 SGTC_3318 9139014 38.6185 µM -0.671445651433995 0.270067432708686 no 2460 0.250968335536349 3628 16643984 SGTC_986 1493-0483 84 µM -0.672113481115109 0.269860460932664 no 2461 0.250755727399886 3584 40079 SGTC_3088 9117578 49.47 µM -0.67241563710011 0.269766843752694 no 2462 0.250659565326091 3689 678341 SGTC_1350 1495-0454 146 µM -0.673215346876254 0.269519147676992 no 2463 0.250405149512186 3652 1069057 SGTC_752 1896-0090 130 µM -0.673373251034287 0.269470253111684 no 2464 0.250354930829929 3629 772567 SGTC_1780 st038448 24.544 µM -0.674490759476595 0.269124346981602 no 2465 0.249999679274407 3667 728868 YDL195W SEC31 SGTC_1941 st076221 61.8 µM -0.674490759476595 0.269124346981602 no 2466 0.249999679274407 3632 2828568 SGTC_2023 5144124 124 µM -0.674586949320626 0.269094583434305 no 2467 0.249969113407854 3622 2830192 SGTC_1993 st073995 70.8 µM -0.674592243601147 0.26909294529925 no 2468 0.249967431122841 3636 3098394 SGTC_463 ikarugamyin 104 µM -0.67695051704956 0.268363755723102 no 2469 0.249218675317873 3677 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1488 4013-0813 75.9 µM -0.677091557644011 0.268320176803245 no 2470 0.249173932520612 3621 2910057 SGTC_2655 perillic acid 100 µM -0.678258668074655 0.267959698047055 no 2471 0.24880385003591 3628 5702197 An apoptosis inducer. SGTC_2171 5739187 198.077 µM -0.678262161546649 0.267958619404427 no 2472 0.248802742720038 3593 2262761 SGTC_666 0272-0154 136 µM -0.678844100996679 0.267778970600025 no 2473 0.248618323656398 3667 6870312 SGTC_1112 tnp00069 1.16933 µM -0.679752387453596 0.267498697501341 no 2474 0.24833062942891 3678 145826 SGTC_987 1497-1013 404 µM -0.681233165584169 0.267042086050601 no 2475 0.247861982719012 3636 1676435 SGTC_2270 7924575 90.91 µM -0.681764583516676 0.26687831450298 no 2476 0.2476939111523 3632 1262135 SGTC_3042 9091578 49.47 µM -0.682053068559554 0.266789430888286 no 2477 0.247602697472688 3605 25236497 SGTC_2786 7743617 45.45 µM -0.685158371838735 0.265833620332594 no 2478 0.246621994605039 3581 583674 SGTC_2844 9010103 25.97 µM -0.686515695982586 0.26541638250183 no 2479 0.246193984970091 3645 2480525 SGTC_710 3448-4187 58 µM -0.688052064550967 0.264944508186718 no 2480 0.24570999766019 3683 3946412 SGTC_3160 9100216 49.47 µM -0.688090317626025 0.264932764726632 no 2481 0.245697953686387 3602 17191039 SGTC_2299 7976368 114.88 µM -0.688394032293558 0.264839535569766 no 2482 0.245602340428996 3646 2979718 SGTC_1476 4112-3294 3.34 µM -0.689095489591424 0.264624277909733 no 2483 0.245381589111389 3692 704369 SGTC_3111 9122088 49.47 µM -0.691160943687123 0.263990964957771 no 2484 0.244732202476802 3571 16876704 SGTC_2210 7115885 190.385 µM -0.69144428348675 0.263904147127819 no 2485 0.244643191589094 3680 2927039 SGTC_3077 9117319 49.47 µM -0.692525044808154 0.263573125954779 no 2486 0.244303831737766 3661 17154678 SGTC_1153 4055-0057 267 µM -0.692884270010073 0.263463147532301 no 2487 0.244191090970527 3683 882706 SGTC_2125 5246583 200 µM -0.694157921714725 0.263073402136861 no 2488 0.243791588844056 3685 835267 SGTC_2029 5175081 200 µM -0.695352835250826 0.262708019178106 no 2489 0.243417105238515 3673 1380876 SGTC_1121 fusaric acid 630.51 nM -0.695354928692213 0.262707379269466 no 2490 0.243416449430855 3674 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_647 0140-0236 81 µM -0.695445222380575 0.262679779680171 no 2491 0.243388164239451 3670 990837 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.696445238876377 0.262374209208876 no 2492 0.243075020180174 3656 688803 SGTC_2652 actinonin 100 µM -0.696827904092354 0.262257328120554 no 2493 0.242955250483487 3652 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_774 k060-0086 136 µM -0.697284308532156 0.262117959043065 no 2494 0.242812443036191 3692 5911235 SGTC_1022 4477-0945 21.3 µM -0.698682445784512 0.261691255865293 no 2495 0.242375253368436 3660 4648966 SGTC_1280 0880-0253 10.1 µM -0.699058954946421 0.261576408454142 no 2496 0.242257594002882 3653 6836607 SGTC_3355 9151058 44.0485 µM -0.700031002797673 0.261280022242025 no 2497 0.241953971582601 3686 17015728 SGTC_729 4092-0585 94.1 µM -0.700837381760257 0.261034280972901 no 2498 0.241702253124534 3669 2169061 SGTC_1548 st061468 90.8 µM -0.701876939014363 0.260717654833698 no 2499 0.241377955822156 3671 390799 SGTC_625 k213-0058 121 µM -0.70343990043992 0.260241983585304 no 2500 0.240890824063459 3749 3655420 SGTC_3175 9106517 49.47 µM -0.705466910792413 0.259625750592039 no 2501 0.240259858470062 3696 41468073 SGTC_3258 9138477 49.47 µM -0.70551526744302 0.259611058854327 no 2502 0.24024481707017 3723 4970355 SGTC_872 0588-0139 234 µM -0.705555324921264 0.259598888899666 no 2503 0.24023235752738 3693 2047100 SGTC_1050 3232-1156 69.3 µM -0.706201629457333 0.259402574352691 no 2504 0.240031378601429 3663 700529 SGTC_1346 1488-2224 62.4 µM -0.70665124519896 0.259266049135844 no 2505 0.239891617350355 3674 3722427 SGTC_1666 st014829 29 µM -0.70669331111727 0.259253277776065 no 2506 0.239878543599298 3710 3858230 SGTC_1119 parthenolide 318.541 nM -0.706912320131081 0.259186791127503 no 2507 0.239810483628253 3801 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2065 5221596 34.26 µM -0.707881465174145 0.258892684383731 no 2508 0.239509435378734 3672 788581 SGTC_977 1348-1378 135 µM -0.710534465928414 0.258088461576188 no 2509 0.238686382878217 3689 X977 SGTC_2040 5100729 123 µM -0.710977019890339 0.257954433264535 no 2510 0.238549238119002 3709 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_3212 9128307 49.47 µM -0.714111342225855 0.25700623222768 no 2511 0.237579166474492 3678 27243542 SGTC_2118 5526350 200 µM -0.714393196810436 0.256921053992945 no 2512 0.237492038797599 3723 743594 SGTC_1569 carminic acid 40.6 µM -0.714588780962027 0.256861955861692 no 2513 0.237431589587549 3721 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2377 9073351 62.6 µM -0.717433383412247 0.256003224967206 no 2514 0.236553363583707 3688 7337946 YHR072W ERG7 SGTC_3214 9129694 49.47 µM -0.718005597784184 0.255830665548433 no 2515 0.236376917646643 3674 17158655 SGTC_2788 5282734 71.43 µM -0.718414701577571 0.255707331683839 no 2516 0.236250812324063 3747 743706 SGTC_1481 3346-2004 36 µM -0.719739274237167 0.255308221497351 no 2517 0.23584277006729 3720 2770522 SGTC_2800 7887935 81.82 µM -0.720273293838625 0.255147406916072 no 2518 0.235678372204631 3692 2961002 SGTC_2274 7947094 46.08 µM -0.72065110470562 0.255033665014743 no 2519 0.235562101365216 3701 2971028 SGTC_1872 amphotericin b 148 nM -0.720672560975185 0.255027206290717 no 2520 0.235555499173856 3719 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1959 st077091 55.8 µM -0.721626912921778 0.254740015718141 no 2521 0.235261944032371 3720 821356 YKL052C ASK1 SGTC_1457 k015-0032 57.3 µM -0.722662459335654 0.254428583174697 no 2522 0.234943642396376 3710 4302660 SGTC_1367 1812-0510 76.9 µM -0.725928677007648 0.253447602260531 no 2523 0.23394124767294 3729 1142582 YDR527W RBA50 SGTC_292 k038-0015 474 µM -0.726044545980831 0.253412838535386 no 2524 0.233905731321384 3704 46368540 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.727604700923801 0.252944995367426 no 2525 0.233427801062441 3742 4174840 SGTC_1798 st045719 60.953 µM -0.729746752811971 0.252303400163897 no 2526 0.232772498737106 3656 3980186 SGTC_1986 st071812 45 µM -0.732738417343603 0.25140876387148 no 2527 0.231858993923518 3686 11838594 SGTC_1377 2944-0135 198 µM -0.733661554987831 0.251133044932128 no 2528 0.231577517500033 3801 1894137 SGTC_296 1222-0039 74.9 µM -0.734140391169436 0.250990091143348 no 2529 0.231431589305664 3691 5984176 SGTC_2952 9073731 13.78 µM -0.735808861449795 0.250492315551682 no 2530 0.230923513810714 3773 16457353 SGTC_2564 betulinic acid 100 µM -0.736164675739998 0.250386228744115 no 2531 0.230815243374029 3741 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2742 clothiapine 36.27 µM -0.736782457441818 0.250202092366372 no 2532 0.230627326451423 3675 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1029 k015-0030 64.7 µM -0.737350352755066 0.250032888526855 no 2533 0.230454659412076 3806 2208316 SGTC_3250 9135583 49.47 µM -0.737573319660747 0.249966472362638 no 2534 0.230386886686163 3761 7699353 SGTC_1525 8-methoxypsoralen 92.5 µM -0.738192795208388 0.249781995520909 no 2535 0.230198650217317 3749 4114 Related to psoralen; DNA damaging agent. SGTC_2499 avocadenofuran 51.48 µM -0.740549271327379 0.249080909267414 no 2536 0.229483388000907 3736 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2110 5483698 200 µM -0.740814469097655 0.24900207462367 no 2537 0.229402970445787 3750 2848765 YHR062C RPP1 SGTC_322 k048-0136 19.3 µM -0.740861405000999 0.248988123494076 no 2538 0.229388739427701 3764 6823282 SGTC_649 1123-0311 367 µM -0.744408396026204 0.247935027819586 no 2539 0.228314720542953 3713 693629 YIL048W NEO1 SGTC_2161 5662504 8.5105 µM -0.745614363165028 0.247577520447816 no 2540 0.22795020193863 3739 2859334 SGTC_2864 9034755 47.6 µM -0.747958682073953 0.246883338930929 no 2541 0.227242539990648 3744 4930451 SGTC_3159 9100096 49.47 µM -0.748648062451641 0.246679403361587 no 2542 0.22703467772408 3718 25236875 SGTC_109 0132-0036 33.701 µM -0.749470936004789 0.24643609540648 no 2543 0.226786704955699 3607 67274 A color developer. SGTC_1652 st011932 78 µM -0.750052458830669 0.246264227826996 no 2544 0.226611555370076 3702 1551076 SGTC_670 4204-0025 119 µM -0.75043992701157 0.246149748283987 no 2545 0.226494895743462 3780 719039 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.750959808568067 0.245996191351001 no 2546 0.226338422140311 3778 364106 SGTC_2487 5918373 44.05 µM -0.751871923423965 0.245726905070101 no 2547 0.226064042013109 3767 2876279 SGTC_432 NS 1619 61.3 µM -0.752828687789523 0.245444606962097 no 2548 0.225776432673903 3817 4552 A K+/calcium channel activator. SGTC_423 5-fluorouracil 457 µM -0.753019948473271 0.245388195448905 no 2549 0.225718963351293 3725 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2753 fluvastatin 17.09 µM -0.753075235390166 0.245371890109676 no 2550 0.225702352479219 3793 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2551 apiole 73.87 µM -0.753140931261098 0.245352515695893 no 2551 0.225682615151511 3615 10659 A possible DNA adduct former. SGTC_2317 5986382 200 µM -0.753347231075364 0.245291681023319 no 2552 0.225620641850534 3797 877883 SGTC_2281 7943571 200 µM -0.754695811929321 0.244894204901108 no 2553 0.225215759996596 3862 1244024 SGTC_106 0092-0003 11.579 µM -0.75521342786274 0.244741736646276 no 2554 0.225060466516144 3724 1072148 SGTC_2147 5545932 89.7195 µM -0.755655740714193 0.244611490070588 no 2555 0.224927813316911 3784 797404 SGTC_435 c-PAF 6.7 µM -0.756651858036211 0.244318303058935 no 2556 0.224629232031477 3786 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2714 st079313 56.9 µM -0.756709532903053 0.244301333429614 no 2557 0.224611951161214 3755 2939799 SGTC_586 0957-0265 8.15 µM -0.756968651819527 0.244225100920499 no 2558 0.224534321789811 3641 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2808 7946468 45.46 µM -0.761009430237429 0.243037969278647 no 2559 0.22332571733932 3799 2970879 SGTC_2834 9001755 58.44 µM -0.76167489137464 0.242842764627125 no 2560 0.223127032319479 3724 2989575 SGTC_156 3474-0145 5.642 µM -0.762783134440248 0.242517863861177 no 2561 0.222796370510529 3683 2265471 SGTC_1539 benzyladenosine 56 µM -0.763061999761056 0.24243614672326 no 2562 0.222713210633197 3753 92208 A nucleotide analog. SGTC_2009 4012297 12.05 µM -0.763827511751033 0.242211902057055 no 2563 0.222485019772528 3788 45595307 SGTC_790 1575-0012 79.1 µM -0.764116806330874 0.2421271870546 no 2564 0.222398818907579 3873 378741 YLR208W SEC13 SGTC_689 0833-0039 98 µM -0.764547619459231 0.242001060530325 no 2565 0.222270485192927 3761 5374726 SGTC_1840 st055363 71 µM -0.765642304962688 0.241680736523702 no 2566 0.22194458255339 3802 676033 SGTC_3142 9086498 49.47 µM -0.766773258351495 0.241350041777121 no 2567 0.221608169232611 3745 25236367 SGTC_2695 st077686 51.995 µM -0.769235135178322 0.240631031187361 no 2568 0.220876868030658 3836 2876092 SGTC_1166 k206-0078 225 µM -0.772144428996475 0.239782854284613 no 2569 0.220014445254477 3811 5404595 SGTC_2939 9044578 71.43 µM -0.772380833541406 0.239714004520776 no 2570 0.219944451137805 3767 2653634 SGTC_1445 4239-0156 97.7 µM -0.7729156593127 0.239558283255001 no 2571 0.219786148308725 3888 4008346 SGTC_2904 7225135 42.03 µM -0.772989623756741 0.239536751922273 no 2572 0.219764260756898 3870 4446116 SGTC_1171 0368-0077 21.4 µM -0.774274336684006 0.239162935674875 no 2573 0.219384288292404 3761 3239779 SGTC_2464 5717415 7.67 µM -0.77510291517419 0.238922011262458 no 2574 0.219139424577061 3777 5285744 SGTC_3356 9151811 4.48 µM -0.776246942251016 0.238589582621283 no 2575 0.218801597050848 3780 1859254 YPR165W RHO1 SGTC_1428 4049-0204 61.7 µM -0.776758849556391 0.238440915847354 no 2576 0.218650529566492 3845 X1428 SGTC_1917 st066507 28.5 µM -0.778113776341521 0.23804766647871 no 2577 0.21825097093168 3768 3156428 SGTC_2348 9022543 33.42 µM -0.779077374168071 0.237768211551071 no 2578 0.217967068697843 3828 3162678 YDL140C RPO21 SGTC_184 1494-0393 24.714 µM -0.779677514664015 0.237594254586502 no 2579 0.217790358578146 3795 3090647 SGTC_2627 acetyl isogambogic acid 100 µM -0.779747587031403 0.237573947936407 no 2580 0.217769731304499 3785 6857789 A caspase activator and apoptosis inducer. SGTC_928 2764-0428 58.7 µM -0.780571574747212 0.237335231548061 no 2581 0.217527257764335 3856 662578 SGTC_1691 st019933 84.6 µM -0.780591372071642 0.237329497712268 no 2582 0.217521433955147 3762 6176082 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.781072542850124 0.237190161152961 no 2583 0.217379914889715 3789 16486 A toxic proline analog. SGTC_3170 9103054 49.47 µM -0.781098691963644 0.237182590227876 no 2584 0.217372225592529 3814 16432970 SGTC_1327 1436-0082 2.18 µM -0.782845979032079 0.236677000979883 no 2585 0.216858781746489 3809 15992205 SGTC_1084 voriconazole 435 nM -0.783240389334066 0.236562957779532 no 2586 0.216742980550495 3799 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_921 1561-0023 372 µM -0.783659869006504 0.236441698993394 no 2587 0.216619858089293 3787 24050882 SGTC_1189 1431-2119 7.28 µM -0.787331628377324 0.23538176695791 no 2588 0.215543879669233 3827 3107275 SGTC_237 nikkomycin 200 µM -0.788064774867785 0.235170443058433 no 2589 0.215329409048575 3821 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2854 9024559 71.43 µM -0.788620274313733 0.235010394363438 no 2590 0.21516698879963 3847 3163529 SGTC_2006 4011487 200 µM -0.792224860487397 0.233973316248219 no 2591 0.214114787634179 3882 45595294 SGTC_424 splitomicin 100 mM -0.793116336852745 0.233717220529776 no 2592 0.213855022721152 3914 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3006 9075424 71.4286 µM -0.79415727396708 0.233418385751919 no 2593 0.213551939198899 3799 7465181 SGTC_2845 9003024 42.97 µM -0.796213005430887 0.232828844483099 no 2594 0.212954119796352 3852 2990173 SGTC_1868 st057644 42.7 µM -0.797203006173181 0.232545228151978 no 2595 0.21266657020945 3830 688665 SGTC_3112 9123419 49.47 µM -0.797979671985381 0.232322862738311 no 2596 0.212441143375859 3859 17015854 SGTC_3051 9093778 49.47 µM -0.799486750401617 0.23189171223146 no 2597 0.212004113178971 3852 17217378 SGTC_592 k241-0073 46.5 µM -0.799716800382355 0.23182593791789 no 2598 0.211937448413518 3814 4230158 SGTC_541 4513-1321 94 µM -0.800425762131564 0.231623301811974 no 2599 0.211732079897086 3830 747515 SGTC_1132 3456-3614 2.5 µM -0.801287803752199 0.23137704531895 no 2600 0.21148252492608 3930 3125502 SGTC_2716 st080858 38.6235 µM -0.801904011886128 0.231201104767109 no 2601 0.211304242626331 3824 5296050 SGTC_139 0099-0334 718.624 µM -0.802394395243776 0.23106114322386 no 2602 0.211162427080724 3870 97690 SGTC_244 nsc-207895 1.295 µM -0.803299772042342 0.230802861657771 no 2603 0.210900744840571 3688 42640 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.80472822400095 0.230395687796052 no 2604 0.210488264406259 3837 688669 SGTC_753 1322-0200 289 µM -0.805001350124412 0.230317880172554 no 2605 0.210409450340361 3869 5403907 SGTC_2076 5212012 200 µM -0.8058372333251 0.230079846759158 no 2606 0.210168353126287 3739 604802 SGTC_2772 vinpocetine 57.06 µM -0.80607226998371 0.230012940466139 no 2607 0.210100589780158 3833 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1905 st060207 84.5 µM -0.808528190326938 0.229314481911069 no 2608 0.209393292255968 3761 1948547 SGTC_2005 4024620 188 µM -0.809626827394801 0.229002417192562 no 2609 0.209077342278125 3824 236743 SGTC_2134 5324836 1.464 µM -0.811605784765714 0.228440901611288 no 2610 0.208508935445105 3826 699272 SGTC_3014 9081533 49.47 µM -0.811889149532078 0.228360562165543 no 2611 0.208427620527735 3874 21367265 SGTC_2990 9074105 71.4286 µM -0.812509513877758 0.228184732201358 no 2612 0.208249664845357 3790 6502001 SGTC_737 1950-0117 57.9 µM -0.812707700558504 0.228128576165781 no 2613 0.208192832563289 3785 5393513 SGTC_1219 1469-0211 33.1 µM -0.813199633385511 0.227989220986485 no 2614 0.208051804795206 3840 6822282 SGTC_3028 9087778 49.47 µM -0.81389643602524 0.227791912073841 no 2615 0.207852141290832 3838 17217395 SGTC_2798 7813637 45.45 µM -0.814753107222946 0.227549466011696 no 2616 0.207606823808476 3856 956368 SGTC_2927 9011802 47.9 µM -0.815188018661927 0.227426437588044 no 2617 0.207482347503448 3876 43912568 SGTC_1828 st055811 49 µM -0.819272721553793 0.226272780680099 no 2618 0.20631541619355 3899 5877589 SGTC_3331 9141060 1.957 µM -0.819996242638812 0.226068779305533 no 2619 0.206109124572014 3842 4906567 YPR165W RHO1 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.820366599911449 0.225964394954735 no 2620 0.206003574988915 3899 279621 SGTC_1076 itraconazole 331 nM -0.82118015310417 0.225735192547373 no 2621 0.205771829833003 3860 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_640 3381-0960 37.1 µM -0.821343891917699 0.225689078301513 no 2622 0.205725206628427 3896 1745025 SGTC_2827 7993847 71.43 µM -0.822044531701538 0.225491815255659 no 2623 0.205525776355555 3921 2985692 SGTC_1046 2001-0062 216 µM -0.824590152475161 0.22477592533346 no 2624 0.204802157019583 3768 739778 SGTC_114 0364-0001 490.298 µM -0.826126449242056 0.224344505988494 no 2625 0.204366182685119 3935 4003655 SGTC_2671 danthron 100 µM -0.827701767811511 0.223902617134007 no 2626 0.203919708867349 3858 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2941 9056145 11.23 µM -0.82840026883856 0.223706840666584 no 2627 0.203721927173722 3733 2119517 SGTC_1027 k015-0025 8.67 µM -0.836158984662454 0.221538776165216 no 2628 0.201532734483371 3873 3598955 SGTC_2180 6301957 200 µM -0.83642358811436 0.221465048835325 no 2629 0.201458323600564 3844 845462 SGTC_664 1222-0054 14.9 µM -0.837521003700148 0.221159422093107 no 2630 0.201149887908905 3845 6813991 SGTC_78 0336-0123 156.75 µM -0.837576000745125 0.221144111943598 no 2631 0.201134438091636 3737 6765896 SGTC_1477 0139-0234 16 µM -0.837831328485089 0.22107304141564 no 2632 0.201062720524546 3900 620880 SGTC_571 k831-0106 44.2 µM -0.842877182537001 0.219671210849527 no 2633 0.199648567978896 3798 4783639 SGTC_3130 9127414 49.47 µM -0.843659591364514 0.219454301368827 no 2634 0.199429827046062 3894 1494646 SGTC_1209 2323-2347 50.3 µM -0.844156652461826 0.219316563613266 no 2635 0.199290936809595 3849 5412760 SGTC_1832 st054113 55 µM -0.846325933199424 0.218716028504832 no 2636 0.198685472314759 3891 1251267 SGTC_488 nitrendipine 139 µM -0.848227125570817 0.218190488989494 no 2637 0.198155746682305 3941 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1116 jasmonic acid  1.58368 µM -0.848875441654571 0.218011443915999 no 2638 0.197975302736059 3961 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1513 0337-0559 19 µM -0.850389437636023 0.217593654561753 no 2639 0.197554303264399 3884 775073 SGTC_3008 9078912 71.4286 µM -0.852415865704383 0.217035182580533 no 2640 0.196991658684478 3890 16648731 SGTC_2989 9073649 71.4286 µM -0.85257750998949 0.216990670040467 no 2641 0.196946819414604 3824 21367202 SGTC_2666 tannic acid 100 µM -0.852697203731843 0.216957712965131 no 2642 0.19691362098516 3908 16134267 A thiamine antagonist. SGTC_2217 6934799 96.0675 µM -0.852993089232707 0.216876254784387 no 2643 0.196831568295155 3833 675606 SGTC_2146 5545642 200 µM -0.853179990456211 0.216824809420311 no 2644 0.196779748956903 3875 825326 SGTC_221 trifluoperazine 10.304 µM -0.853530777056374 0.216728272953496 no 2645 0.196682513850647 3876 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_324 1315-0088 19.6 µM -0.853758985068295 0.216665483459555 no 2646 0.196619272129964 3883 6787421 SGTC_1107 amlodipine 47 µM -0.854083847666348 0.216576118430348 no 2647 0.196529266439955 3702 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1401 3807-4679 7.6 µM -0.854531126363078 0.216453113389987 no 2648 0.196405385281523 3854 3291456 SGTC_3328 9140624 29.0385 µM -0.856521247724944 0.215906305243351 no 2649 0.195854762594568 3953 4904392 SGTC_1713 st033146 12.748 µM -0.856854717516821 0.215814759041978 no 2650 0.195762590576028 3865 674619 SGTC_32 0928-0142 34.1 µM -0.858471657413833 0.215371185771249 no 2651 0.195316037146628 3865 2244242 SGTC_3300 9124615 50.48 µM -0.859197357777058 0.215172277321858 no 2652 0.195115820440194 3978 24824903 SGTC_1241 0364-0022 50.8 µM -0.859672452595321 0.215042115550017 no 2653 0.19498481200817 3940 4563895 SGTC_174 3553-0389 74.3 µM -0.860820998512684 0.21472763724439 no 2654 0.194668318971686 3957 738071 SGTC_2715 st079500 56.4 µM -0.863872364632383 0.213893455355424 no 2655 0.193829004758808 3856 28246688 SGTC_1267 0828-0272 9.49 µM -0.864085752737636 0.213835190029982 no 2656 0.193770392483113 3998 745334 SGTC_2356 9061756 188.97 µM -0.864275450188509 0.213783401165798 no 2657 0.193718296499824 3955 20104043 SGTC_1013 4112-3890 241 µM -0.865239285953391 0.213520379453683 no 2658 0.193453733418407 3875 705171 SGTC_319 1348-1596 45.5 µM -0.866620385501556 0.213143819279813 no 2659 0.193075020123254 4021 5380505 SGTC_1000 4048-0884 8.67 µM -0.866925727218716 0.213060619428437 no 2660 0.192991353073115 3954 13040088 SGTC_1838 st055369 84.5 µM -0.867109578456003 0.213010532578221 no 2661 0.192940986455895 3922 676036 SGTC_1451 4152-0210 104 µM -0.867493478766195 0.212905968231187 no 2662 0.192835841660442 3901 659563 SGTC_25 0118-0223 35.662 µM -0.86987633692316 0.212257610688375 no 2663 0.19218399416842 3929 5333628 SGTC_213 1246-0773 967 nM -0.872830511382047 0.211455406753175 no 2664 0.191377733174218 3917 6251622 SGTC_513 4245-1575 41.7 µM -0.874526515392072 0.210995661448485 no 2665 0.190915793389351 3856 719745 SGTC_975 1335-0046 28.5 µM -0.874686855678757 0.210952227448252 no 2666 0.190872157001416 3940 16486740 SGTC_2200 6600604 21.907 µM -0.875510705613533 0.210729140397874 no 2667 0.190648043882945 3903 2904777 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.876280070717609 0.210520932097184 no 2668 0.190438898268309 4017 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1559 coumarin 343 70.1 µM -0.877550695752213 0.210177335539466 no 2669 0.190093797875554 3953 108770 A hepatotoxic, DNA x-linker. SGTC_2253 7938677 135.83 µM -0.878939156084971 0.209802251388515 no 2670 0.189717133284932 4024 2301972 SGTC_3057 9095946 49.47 µM -0.879099396991944 0.209758988620346 no 2671 0.189673692342357 3957 24540043 SGTC_1777 st045864 34.765 µM -0.879289656322167 0.209707628115933 no 2672 0.189622121419865 3904 4691462 SGTC_2781 5567276 71.43 µM -0.881001371485455 0.209245883257907 no 2673 0.1891585388364 3998 2853274 SGTC_3161 9100388 49.47 µM -0.884556230822573 0.20828885406791 no 2674 0.188198011042652 4001 25236368 SGTC_1936 st074407 74.3 µM -0.886952898954893 0.207645089741207 no 2675 0.187552129824395 4003 809813 SGTC_1708 st033234 31.827 µM -0.887740333122863 0.207433835437545 no 2676 0.18734022245894 4047 674664 SGTC_2091 4-phenylthiadiazole 200 µM -0.88916976620747 0.207050669280333 no 2677 0.186955924394281 3938 270010 SGTC_1286 0929-0070 131 µM -0.891488010805927 0.206430144125306 no 2678 0.18633371032573 4052 1420408 SGTC_475 α-linolenic acid 10 µM -0.896433884812162 0.205109969449184 no 2679 0.185010538346032 3981 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1733 st037357 54.9 µM -0.896551527583057 0.205078628934396 no 2680 0.184979136567013 3877 1272339 YGL099W LSG1 SGTC_2536 dehydroabietamide 32.04 µM -0.898718083668618 0.204501958568288 no 2681 0.184401421123522 4048 3983547 SGTC_1811 st050069 61.5 µM -0.899529216518643 0.204286308561948 no 2682 0.184185420424626 3913 3877702 SGTC_2636 apigenin dimethyl ether 100 µM -0.900233942669391 0.204099058102002 no 2683 0.183997883206402 3995 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2398 5228213 48.84 µM -0.900599233369756 0.204002038161099 no 2684 0.183900721183357 3981 80771 YMR134W ERG29 SGTC_760 0568-0725 82.9 µM -0.903412536956852 0.203255755676836 no 2685 0.18315349433184 3998 3916171 SGTC_497 capsazepine 133 µM -0.904651170558962 0.202927701743088 no 2686 0.182825108650269 3949 2733484 A calcium channel blocker. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.90472236541409 0.202908855296736 no 2687 0.182806244695444 4028 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_889 0919-1524 82.7 µM -0.904914315500559 0.202858048168606 no 2688 0.182755391206946 3997 3905452 SGTC_972 1319-0219 195 µM -0.905747364884437 0.202637637010676 no 2689 0.182534793122974 3948 23903702 SGTC_905 2-aminofluorene 215 µM -0.907572507766596 0.202155234830733 no 2690 0.182052062454184 3970 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1848 st056003 16.4 µM -0.909675058744478 0.201600363672169 no 2691 0.18149695068311 4007 146492 SGTC_1051 3253-3903 78 µM -0.914021697035844 0.200456166064958 no 2692 0.180352722490946 3980 5509239 SGTC_1283 0922-0125 16.4 µM -0.914555950926584 0.200315800145486 no 2693 0.180212396164309 3985 3360884 SGTC_1342 1486-1464 234 µM -0.914976146854558 0.200205442471412 no 2694 0.180102076289226 4013 3253938 SGTC_2402 5553605 200 µM -0.916000634319628 0.199936530566308 no 2695 0.179833281104237 4080 6758546 SGTC_43 0570-0105 72.5 µM -0.916541766325532 0.199794579596807 no 2696 0.179691405838514 4001 1114046 YDL195W SEC31 SGTC_1950 st077106 7.18 µM -0.92340715056532 0.197998905050442 no 2697 0.177897533373381 3977 13831864 SGTC_2425 5628681 7.85 µM -0.925850251179378 0.197362258983149 no 2698 0.177261904050023 4063 5714958 SGTC_1369 1866-0067 208 µM -0.927639241273283 0.196896853345544 no 2699 0.176797367574351 3995 3531355 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.928782729631665 0.196599723320373 no 2700 0.176500848225084 3986 688667 SGTC_1431 4049-0260 9.09 µM -0.930048480762854 0.196271140852328 no 2701 0.176172991801803 3986 3854841 SGTC_266 formosanin C 406 nM -0.931254186723987 0.195958455631048 no 2702 0.175861047066892 3901 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2976 9009005 19.48 µM -0.933113719512507 0.195476801249804 no 2703 0.175380628118259 4035 2993148 SGTC_623 k072-0108 16.9 µM -0.934222626440781 0.195189915792167 no 2704 0.175094533270481 3977 5382803 SGTC_1039 k821-0043 94 µM -0.934856270456581 0.195026100604873 no 2705 0.17493118790241 4040 15992768 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.935685742007089 0.19481178473687 no 2706 0.174717506881287 4047 91467 include heat shock SGTC_1041 0206-0046 107 µM -0.936054383816167 0.19471658239194 no 2707 0.174622593894411 4036 50494 SGTC_1093 fluphenazine 7.97 µM -0.936319377387327 0.194648164861122 no 2708 0.174554387106141 4022 6602611 An atypical antipsychotic. SGTC_2850 9015429 58.44 µM -0.938300682678771 0.194137083982638 no 2709 0.174044954512273 4071 6457570 SGTC_1554 st069299 38.7 µM -0.938803415198626 0.194007533457426 no 2710 0.173915842576117 3986 24207999 SGTC_231 b-estradiol 524 µM -0.938977022020267 0.193962808476999 no 2711 0.173871270964659 3998 450 A steroid. SGTC_949 1165-0505 146 µM -0.94053694765006 0.193561218845654 no 2712 0.173471103434201 4054 6244267 SGTC_1803 st050068 52.4 µM -0.940925780796614 0.193461196061193 no 2713 0.173371447455816 4082 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_776 4476-4378 112 µM -0.941001908015631 0.19344161691505 no 2714 0.17335194069988 4080 2892008 SGTC_158 k038-0087 26.446 µM -0.941377264345472 0.193345096761996 no 2715 0.17325578023211 3936 X158 SGTC_1212 0520-0165 585 µM -0.941497185236135 0.19331426617149 no 2716 0.173225065521171 4166 5403258 SGTC_1467 k284-1082 293 µM -0.941734147084714 0.193253354217084 no 2717 0.173164383917232 3985 3334705 SGTC_1953 st076800 12.1 µM -0.942085847740342 0.193162969808974 no 2718 0.173074344760704 4042 297591 SGTC_693 4161-2696 114 µM -0.942909342468817 0.192951438864152 no 2719 0.172863637927029 4055 805759 SGTC_2889 9059656 51.95 µM -0.943105615748602 0.192901043066983 no 2720 0.172813441799317 4114 3949838 SGTC_589 1227-0070 34.1 µM -0.947264296761773 0.191835136621278 no 2721 0.17175205956951 4085 2841384 SGTC_1215 3852-0577 11.2 µM -0.948082876658667 0.191625752937122 no 2722 0.171543632361856 4086 2884876 SGTC_2664 lyso-paf C-16 73.48 µM -0.950231549560046 0.191076812472984 no 2723 0.170997305515959 4002 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3207 9114163 49.47 µM -0.950345027359991 0.191047848130459 no 2724 0.170968483349099 4082 849233 SGTC_1563 conessine 56.1 µM -0.953112159177944 0.190342392448341 no 2725 0.170266623038082 4111 441082 An anti-amoebic, histamine inhibitor. SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.953793475340778 0.190168942722196 no 2726 0.170094096375765 4054 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1873 rapamycin 2 nM -0.953929578355437 0.190134305206923 no 2727 0.170059645045184 4004 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_916 4466-0038 42 nM -0.954068463896336 0.190098963549819 no 2728 0.170024493993147 4106 5722064 YGL116W CDC20 SGTC_97 0535-0701 19.132 µM -0.954959489427186 0.189872323832116 no 2729 0.169799091856877 3944 2832013 YGL099W LSG1 SGTC_165 k038-0023 64.381 µM -0.956613586034747 0.189452031368616 no 2730 0.169381164434655 4046 46368543 SGTC_528 3492-0019 172 µM -0.959848789566298 0.188631649138373 no 2731 0.168565661478581 4039 2869262 SGTC_3141 9094609 49.47 µM -0.960459346548847 0.188477070247385 no 2732 0.168412040993984 3996 25236309 YDL196W YDL196W SGTC_1606 st000094 49.2 µM -0.960871174732191 0.188372849017291 no 2733 0.168308472950009 4079 1242210 SGTC_71 0417-1750 47.813 µM -0.961046674193472 0.188328446227753 no 2734 0.168264350160728 4065 6811472 SGTC_2284 7945075 39.21 µM -0.961677768539291 0.188168827593596 no 2735 0.168105746534249 4062 1245402 SGTC_597 k018-0003 82.8 µM -0.962776691738359 0.187891083344827 no 2736 0.167829800060489 4110 6786234 SGTC_608 k048-0125 159 µM -0.962782167838387 0.187889699937521 no 2737 0.167828425708244 4093 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_341 1486-1430 230 µM -0.962819003262699 0.187880394501202 no 2738 0.167819181206374 4025 2054753 YPL210C SRP72 SGTC_1982 st072467 71.9 µM -0.962888454291175 0.187862850421832 no 2739 0.167801752133038 4016 3163533 SGTC_299 1273-0059 1.44 µM -0.964560622066417 0.187440748245713 no 2740 0.167382465364164 3924 2848077 SGTC_620 0109-0052 432 µM -0.964618951103202 0.187426034944566 no 2741 0.167367851878675 4038 493037 SGTC_2258 7960471 200 µM -0.964948386406449 0.187342949411874 no 2742 0.167285332126158 4075 2974708 SGTC_1321 1326-2144 215 µM -0.966053829585849 0.187064316532669 no 2743 0.167008622999706 4065 3513030 SGTC_252 miconazole 1.30953 nM -0.967015293817346 0.186822182871364 no 2744 0.166768194126961 3955 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_76 0433-0009 400.328 µM -0.967277144850879 0.186756272335423 no 2745 0.166702752972766 4142 2841569 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.967847379606178 0.18661278832812 no 2746 0.166560298675443 4097 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3303 9125618 40.5795 µM -0.967973118453697 0.18658115876737 no 2747 0.166528897558648 4082 22695467 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.969001604563205 0.186322568108003 no 2748 0.166272194299846 4085 65057 A dermal irritant. YDR527W RBA50 SGTC_917 harmaline 728.087 nM -0.96966010812692 0.186157118238675 no 2749 0.16610797048137 4035 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.970101109392246 0.186046367027931 no 2750 0.165998048042781 4058 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_542 3381-0244 89.3 µM -0.970551412322152 0.185933321993992 no 2751 0.165885855618179 4083 1112843 SGTC_1643 st009866 20.2 µM -0.970625609432507 0.185914699476872 no 2752 0.165867374202977 3999 3156273 YOR207C RET1 SGTC_2719 novobiocin 32.65 µM -0.970678794716275 0.185901351368748 no 2753 0.165854127345467 4059 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1546 5-methoxyflavanone 78.7 µM -0.971230929694111 0.18576281511481 no 2754 0.165716647498988 4045 147795 SGTC_1885 st057546 99.9 µM -0.972060351922567 0.185554825077414 no 2755 0.165510262533848 4102 702008 SGTC_1396 3511-0007 98.6 µM -0.972512892912239 0.185441404611962 no 2756 0.165397726983793 4061 X1396 SGTC_1775 st081588 35.1725 µM -0.972942949602958 0.18533365928152 no 2757 0.165290828599806 4068 1426443 YGL099W LSG1 SGTC_1508 1080-0625 72.9 µM -0.973636674388114 0.185159937142383 no 2758 0.165118484983121 3930 767111 SGTC_2973 9094665 17.96 µM -0.974302818565844 0.184993216943657 no 2759 0.164953102799062 4099 25237061 YIL048W NEO1 SGTC_1712 st032288 53.4 µM -0.977787678747577 0.184122559593384 no 2760 0.164089673098991 3972 2883011 SGTC_2202 7226349 200 µM -0.982787464382328 0.182877876686201 no 2761 0.162856026370212 4022 844334 SGTC_82 0054-0107 293.755 µM -0.983713356649942 0.182647955966916 no 2762 0.16262823534173 4010 3104697 SGTC_2893 9048488 25.97 µM -0.984226999212594 0.18252048437339 no 2763 0.162501956760178 4110 6467338 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.985915025251178 0.182101955434977 no 2764 0.16208740654466 4134 6710655 SGTC_1768 st044301 37.178 µM -0.986100009243187 0.182056127034155 no 2765 0.162042019561638 4079 3931349 SGTC_3126 9127922 49.47 µM -0.987390770922588 0.181736551208005 no 2766 0.16172555350026 4140 45595682 SGTC_3248 9135562 49.47 µM -0.988019305358196 0.181581061384333 no 2767 0.161571596759024 4060 17650701 SGTC_2606 farnesol 9.78 µM -0.990010836463466 0.181088937048843 no 2768 0.161084411197928 4136 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_576 1073-0113 22.7 µM -0.990685632317905 0.180922378937657 no 2769 0.160919554456827 4214 5439563 SGTC_1296 1068-0102 11.9 µM -0.992000160305915 0.180598193185469 no 2770 0.160598723608427 4089 767053 SGTC_459 nigericin 15.3 µM -0.994568728760322 0.179965791110689 no 2771 0.159973031462603 4159 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_692 k241-0027 77.8 µM -0.996299268490221 0.179540503460459 no 2772 0.159552379556933 4146 3600480 SGTC_667 1498-1044 59 µM -0.996878286362169 0.179398348454416 no 2773 0.159411796254202 4100 6739982 SGTC_1875 nocodazole 6 µM -0.99706798232517 0.179351791484559 no 2774 0.159365756449256 4106 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_457 grayanotoxin iii 135 µM -1.00115966855513 0.178349421072531 no 2775 0.158374810795819 3935 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_794 k038-0031 316 µM -1.00133318272619 0.178306992195912 no 2776 0.158332877777721 4078 6624242 SGTC_3041 9091929 49.47 µM -1.00228305119047 0.17807483656593 no 2777 0.158103452994991 4097 25236887 SGTC_20 0481-0013 4.944 µM -1.00330829635608 0.177824472203651 no 2778 0.15785606722643 4119 182045 SGTC_1674 st016616 23.6 µM -1.00514744841817 0.177375908887655 no 2779 0.157412927749553 4041 625830 SGTC_126 0417-1624 672.48 µM -1.00571073392331 0.177238668382405 no 2780 0.157277369118017 4156 41912 YDL195W SEC31 SGTC_2942 9052777 62.25 µM -1.00948242158561 0.176321452144647 no 2781 0.156371663905919 4160 6469503 SGTC_2322 7413319 38.22 µM -1.00990863257877 0.176217993412793 no 2782 0.156269533197194 4136 1840400 SGTC_698 k064-0052 127 µM -1.01145408658202 0.175843171223585 no 2783 0.155899572763841 4182 5088751 SGTC_763 3453-1109 128 µM -1.01283024314394 0.175509834445614 no 2784 0.155570626179401 4126 1560353 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.01363793172044 0.175314380326168 no 2785 0.155377775468939 4156 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1989 st071868 50.2 µM -1.01497308216454 0.174991587460089 no 2786 0.15505932947562 4087 16414057 SGTC_2272 7805186 180 µM -1.01966846042104 0.173859405961529 no 2787 0.153942862293567 4124 2956062 YPR165W RHO1 SGTC_815 1582-0027 36.9 µM -1.02058281415119 0.173639473901811 no 2788 0.153726067594133 4157 3128206 SGTC_3084 9116877 49.47 µM -1.02144852770455 0.173431404616146 no 2789 0.153520991920225 4045 27241325 SGTC_1572 epiandrosterone 68.9 µM -1.02195803331648 0.173309022084016 no 2790 0.15340038175883 4029 441302 A steroid. SGTC_2563 tomatine 8.54 µM -1.02262788357048 0.173148208679161 no 2791 0.153241910347466 4035 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1081 sertraline 6 µM -1.02275901070687 0.173116739633591 no 2792 0.15321090133513 4105 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_796 1234-0020 70.7 µM -1.02466404631689 0.172659963368436 no 2793 0.152760866582631 4046 46495034 SGTC_1450 4112-4260 37.6 µM -1.0267519073414 0.172160233865326 no 2794 0.152268650192552 4105 1633175 SGTC_2704 st078022 71.1 µM -1.027236212615 0.17204444742696 no 2795 0.152154625103205 4180 54697681 SGTC_2051 5263410 176 µM -1.02955209408167 0.171491459930716 no 2796 0.151610156722947 4121 227584 SGTC_1257 0669-0121 16 µM -1.02970010279727 0.171456156984326 no 2797 0.151575403661172 4144 4307855 SGTC_1887 st057648 70.8 µM -1.03004454767629 0.171374018190207 no 2798 0.151494547075451 4115 688672 SGTC_3043 9092303 49.47 µM -1.03221131568073 0.170857892087015 no 2799 0.150986567616906 4118 25236084 SGTC_2824 7998404 51.95 µM -1.0361390536908 0.169924839911481 no 2800 0.150068637443065 4093 837851 SGTC_487 nimodipine 119 µM -1.03678870983735 0.169770826543459 no 2801 0.149917169198431 4077 4497 L-type voltage-gated calcium channels inhibitor SGTC_3211 9128781 49.47 µM -1.03914513751184 0.169212941987277 no 2802 0.149368620603767 4141 17194361 SGTC_759 3486-0358 89.3 µM -1.04056319855538 0.168877783780868 no 2803 0.149039159308029 4134 875103 SGTC_6 0844-0013 19.835 µM -1.04062468177236 0.168863261898322 no 2804 0.149024885762864 4252 1584900 SGTC_843 0310-0051 143 µM -1.04265295616458 0.168384648271327 no 2805 0.148554526672884 4159 2065037 SGTC_256 clotrimazole 625 nM -1.0438876418572 0.168093726035951 no 2806 0.148268688240122 4071 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_411 enrofloxacin 100 µM -1.04393040848715 0.168083654967835 no 2807 0.148258794061514 4218 71188 A bacterial gyrase inhibitor. SGTC_3135 9127742 49.47 µM -1.04557217737121 0.167697330139847 no 2808 0.147879300218625 4230 3643468 SGTC_3145 9085516 49.47 µM -1.04622750254813 0.167543285300656 no 2809 0.147728003974476 4165 25236195 SGTC_3321 9137793 26.8275 µM -1.04682699983823 0.167402443578441 no 2810 0.147589687648579 4107 4904192 SGTC_809 3998-0021 90 µM -1.04786448190159 0.167158885075157 no 2811 0.147350524276328 4087 715485 SGTC_35 0133-0054 64.071 µM -1.04937981954949 0.166803556295875 no 2812 0.147001671205927 4157 99677 SGTC_811 0416-0114 265 µM -1.04957316580061 0.166758253963803 no 2813 0.146957199923534 4196 6612453 SGTC_2481 5478948 45.16 µM -1.0514915391384 0.166309196332537 no 2814 0.146516446646264 4188 77792 SGTC_2434 5670830 169.91 µM -1.0533956283328 0.165864255336028 no 2815 0.146079853478772 4188 1549830 SGTC_2998 9066762 71.4286 µM -1.05437214846229 0.165636364249223 no 2816 0.14585628422863 4214 4945196 SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.05450727544425 0.165604845539868 no 2817 0.145825365724085 4155 77254 SGTC_2836 9010338 19.48 µM -1.055074353864 0.165472615365765 no 2818 0.145695660127895 4135 2994051 SGTC_450 aminopyrene 156 nM -1.0592603278307 0.164498652161851 no 2819 0.144740618581866 4071 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.06124755820171 0.164037580589151 no 2820 0.14428870568721 4282 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_248 streptozotocin 5.23457 mM -1.06465686357509 0.163248518135473 no 2821 0.143515618622029 4186 5300 DNA alkylating agent. SGTC_1304 1165-0502 251 µM -1.06468684908919 0.16324158913418 no 2822 0.143508831596442 4152 767425 SGTC_1235 benzylparaben 21.5 µM -1.06554182242186 0.163044103764172 no 2823 0.14331540511965 4178 7180 SGTC_135 0933-0004 26.348 µM -1.06565370551288 0.163018272028595 no 2824 0.143290106074205 4139 21230617 YGL099W LSG1 SGTC_2761 levamisole 97.89 µM -1.06604683786315 0.162927526141929 no 2825 0.143201234762172 4160 26879 An alkaline phosphatase inhibitor. SGTC_2734 clemastine 41.6 µM -1.06796559645904 0.162485094692306 no 2826 0.14276801547115 4201 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2718 lomofungin 53.02 µM -1.06866366001133 0.162324327848368 no 2827 0.142610625983706 4151 5351222 A RNA synthesis inhibitor. SGTC_1427 4048-4900 550 nM -1.06924023345289 0.162191618774087 no 2828 0.142480716872643 4156 24132586 SGTC_2287 7945887 168.79 µM -1.06998300834385 0.162020759508241 no 2829 0.142313478531736 4179 1245853 SGTC_2793 7325131 81.82 µM -1.07030504704481 0.161946717930763 no 2830 0.142241011691943 4129 4176441 SGTC_1227 3909-8010 46.6 µM -1.07044594807902 0.161914329580703 no 2831 0.142209313254968 4144 15982272 SGTC_1970 st070122 35.8 µM -1.07103114207898 0.161779858568077 no 2832 0.142077713603687 4190 102928 SGTC_2549 cedrol 20.94 µM -1.07134220576484 0.161708409256963 no 2833 0.142007794515454 4115 6708665 A sedative which affects the nervous system. SGTC_1929 genistein trimethyl ether 50.5 µM -1.07223461474959 0.16150354285494 no 2834 0.141807333296948 4159 136420 SGTC_2132 5317594 122.667 µM -1.07276822983532 0.161381124070555 no 2835 0.141687559302908 4124 794577 SGTC_1134 3477-0009 42.5 µM -1.07355364842907 0.161201048148307 no 2836 0.141511390774236 4243 3973534 SGTC_1224 0823-0416 294 µM -1.07468853555101 0.160941079891395 no 2837 0.141257099111217 4242 3598164 SGTC_2440 5628896 157.78 µM -1.0754454487328 0.160767846221279 no 2838 0.141087671542654 4154 5522048 SGTC_927 2425-1185 123 µM -1.07807470273474 0.160167038891015 no 2839 0.140500209980446 4107 730375 SGTC_260 nsc-65238 3.989 µM -1.08068750842103 0.159571446099145 no 2840 0.139918070761614 4160 3246252 SGTC_1281 0884-0031 11.8 µM -1.08070878204011 0.159566602704119 no 2841 0.139913337687118 4184 1548255 SGTC_642 0335-0876 158 µM -1.08083265983216 0.15953840118298 no 2842 0.13988577882045 4202 6812350 SGTC_1156 4092-0367 4.88 µM -1.08156111945265 0.159372628992067 no 2843 0.139723794375912 4191 1357585 SGTC_1984 st072354 53.1 µM -1.08162077240443 0.159359059043105 no 2844 0.139710535255986 4057 5762938 SGTC_2414 st077232 92.9 µM -1.08316664074491 0.159007666279466 no 2845 0.139367231898658 4118 729801 SGTC_1078 idebenone 36.1 µM -1.08337629667682 0.158960048321792 no 2846 0.139320716161112 4227 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1362 1611-0397 101 µM -1.08402778767317 0.158812138523029 no 2847 0.139176239209795 4145 27816 SGTC_201 4262-0159 12.803 µM -1.08554599341209 0.158467806260131 no 2848 0.138839952309187 4209 1341029 SGTC_2386 9075165 157.42 µM -1.08647488749291 0.158257372766834 no 2849 0.13863447268986 4156 16452277 SGTC_845 0330-0138 4.51 µM -1.08668328677075 0.158210186779839 no 2850 0.138588401387144 4142 9039800 SGTC_2098 5376439 882.5 nM -1.08700571510077 0.158137200407664 no 2851 0.138517141978469 4217 2844116 SGTC_2002 4023503 131 µM -1.09115450273575 0.157200033556718 no 2852 0.137602451902752 4194 4736863 YCR052W RSC6 SGTC_2541 muurolladie-3-one 83.07 µM -1.09152268472341 0.157117041964061 no 2853 0.137521477843081 4178 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2037 5169046 200 µM -1.09163103203272 0.15709262497647 no 2854 0.13749765527566 4244 5718022 SGTC_2182 6325192 200 µM -1.09179900462599 0.157054775857937 no 2855 0.137460728332292 4158 736248 SGTC_27 0485-0001 32.618 µM -1.0922753136734 0.156947482175339 no 2856 0.137356053805313 4134 2054479 SGTC_2725 haloperidol 53.21 µM -1.09447467950796 0.156452677161707 no 2857 0.13687342327884 4119 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_226 1,3-diallylurea 8.28947 mM -1.09491944449284 0.156352740624269 no 2858 0.136775964777663 4116 74537 YKL182W FAS1 SGTC_9 0092-0002 10.449 µM -1.09733323967464 0.155811105971469 no 2859 0.136247872736508 4177 759368 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.09776133937128 0.155715173438312 no 2860 0.136154358606635 4170 6708739 YPR165W RHO1 SGTC_627 1391-0720 175 µM -1.09797677558803 0.155666911237641 no 2861 0.136107315322297 4170 997839 SGTC_1015 4130-4525 82 µM -1.10026074942451 0.155155860268676 no 2862 0.135609264262962 4198 1363237 SGTC_2774 tamoxifen 10.92 µM -1.10038414002452 0.155128282554804 no 2863 0.135582392886196 4177 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_725 1497-0963 19 µM -1.10217929632226 0.154727432404411 no 2864 0.135191865477687 4312 3549977 SGTC_315 k915-0449 187 µM -1.10466898991531 0.154172629022311 no 2865 0.13465152252796 4205 20970215 YNL149C PGA2 SGTC_215 1287-0124 461.5 µM -1.10484509995397 0.154133434548706 no 2866 0.134613357239546 4216 5560863 SGTC_1616 st002734 56.1 µM -1.1057942363259 0.153922311359905 no 2867 0.134407795139215 4136 4026101 SGTC_985 1493-0307 8.71 µM -1.10836307550435 0.153351866400494 no 2868 0.133852522437255 4217 3278274 SGTC_954 1189-0853 2.85 µM -1.10879265382895 0.153256609675762 no 2869 0.133759820152908 4135 2828194 SGTC_2869 9037858 32.47 µM -1.11011093952505 0.152964531605953 no 2870 0.133475611888333 4156 27187042 SGTC_2352 9027995 87.8 µM -1.11183888003683 0.152582250064868 no 2871 0.133103715833187 4173 2997347 SGTC_1030 k029-0042 36.7 µM -1.11269999068502 0.152391978796163 no 2872 0.132918649774906 4183 6080581 SGTC_257 daunorubicin 18.5 µM -1.11287235751699 0.152353911493247 no 2873 0.132881626754874 4229 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1919 st067113 52.3 µM -1.11399607873892 0.15210589180592 no 2874 0.132640434446135 4225 1268243 SGTC_1568 digitonin 820 nM -1.11544955166885 0.151785489596079 no 2875 0.132328912712545 4208 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_366 0181-0206 4.31 µM -1.11769272839483 0.151291886596761 no 2876 0.131849124738983 4244 274874 SGTC_2061 5245884 80.95 µM -1.12152089542823 0.150451980515789 no 2877 0.131033101118497 4188 573863 SGTC_1412 3909-8563 178 µM -1.12491866925542 0.149709110383475 no 2878 0.130311750010518 4289 23767530 SGTC_991 3996-0057 64.7 µM -1.12595791175256 0.149482385786138 no 2879 0.130091667358993 4277 715343 SGTC_2216 7189485 200 µM -1.1259869555127 0.14947605279646 no 2880 0.130085520395808 4231 731273 SGTC_2300 7976697 71.57 µM -1.12615473690747 0.149439471581551 no 2881 0.130050014257122 4110 2236109 SGTC_394 menadione 8.33 µM -1.12941990362617 0.148728760178906 no 2882 0.129360370223962 4205 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1893 st059353 36.1 µM -1.12993141216804 0.148617627866542 no 2883 0.129252563265227 4234 3112488 SGTC_1272 0839-0021 27 µM -1.13067897183792 0.148455310058799 no 2884 0.129095117557226 4244 5027250 SGTC_2537 larixol 68.93 µM -1.13097434055895 0.148391209266419 no 2885 0.129032945759615 4203 6708759 SGTC_911 3456-4043 236 µM -1.13132971412174 0.1483141107875 no 2886 0.12895817113835 4226 914281 SGTC_3068 9116768 49.47 µM -1.13141100447079 0.148296478570494 no 2887 0.128941070952641 4204 41904888 SGTC_2962 9082311 13.18 µM -1.13294418598009 0.147964187712303 no 2888 0.128618846386106 4203 16459453 SGTC_1141 3253-0389 52.6 µM -1.13340702750312 0.147863972746761 no 2889 0.128521682149841 4226 5402031 SGTC_2757 clomiphene 4.22 µM -1.13664413955874 0.147164340144978 no 2890 0.12784354000069 4256 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2826 7992541 19.48 µM -1.13685236405581 0.147119412962338 no 2891 0.127800004357606 4246 2985066 SGTC_544 k015-0020 52.4 µM -1.1379669242282 0.146879088255885 no 2892 0.127567146951666 4230 3008304 SGTC_1514 1189-1591 158 µM -1.1385229441727 0.146759296122752 no 2893 0.127451091875787 4238 767698 YMR146C TIF34 SGTC_1560 lithocholic acid 53.1 µM -1.13961396295263 0.146524431310472 no 2894 0.127223582782112 4145 9903 A bile acid which acts as a detergent. SGTC_1638 st008370 60.6 µM -1.14226966303933 0.145953790788149 no 2895 0.126670973599087 4182 24207134 SGTC_155 k072-0202 43.6 µM -1.14232866633869 0.145941129502072 no 2896 0.126658714957306 4213 5857737 SGTC_1056 3448-1962 115 µM -1.14554710054022 0.145251616366726 no 2897 0.125991298044819 4231 715507 SGTC_1688 st021091 57.6 µM -1.1457253454426 0.145213493575244 no 2898 0.125954406634169 4260 3656366 SGTC_2214 7179297 48.276 µM -1.14696614728562 0.144948299037332 no 2899 0.125697806160262 4288 769744 SGTC_350 k064-0020 19.8 µM -1.14785437726576 0.144758659467393 no 2900 0.125514342425302 4270 2790705 SGTC_1174 0739-0097 51.1 µM -1.14928672978867 0.144453200351496 no 2901 0.125218884090388 4276 728447 SGTC_3034 9090421 49.47 µM -1.15174551318403 0.14392986111795 no 2902 0.124712831889743 4143 17173761 SGTC_2100 5377183 190 µM -1.15243649862939 0.14378301895692 no 2903 0.12457087500389 4257 2844202 SGTC_880 0833-0487 87.2 µM -1.15432908005618 0.143381341887318 no 2904 0.124182639316417 4242 76075 SGTC_2801 7907800 81.82 µM -1.15476360291228 0.143289226822451 no 2905 0.124093622848211 4264 6620925 SGTC_1994 st072947 40.9 µM -1.15479051707806 0.143283522568168 no 2906 0.124088110673694 4298 5286565 YDL195W SEC31 SGTC_1416 3966-0321 25.3 µM -1.15535004604719 0.143164969361095 no 2907 0.123973554752702 4289 582530 YLR208W SEC13 SGTC_514 4466-0038 2.65 nM -1.15536866085731 0.143161026387363 no 2908 0.123969744896844 4055 5722064 SGTC_1486 3970-0793 4.53 µM -1.15683839729516 0.142849939558924 no 2909 0.123669195482209 4271 2844330 SGTC_3329 9141233 27.5565 µM -1.15831023018304 0.142538867188826 no 2910 0.1233687290272 4207 4909101 YNL103W MET4 SGTC_3169 9102970 49.47 µM -1.15914340965746 0.142362977646149 no 2911 0.123198866978473 4307 17027839 SGTC_1406 3909-7906 11.9 µM -1.16059705437634 0.142056455599392 no 2912 0.122902901949948 4257 X1406 SGTC_45 0kpi-0036 14.9 µM -1.164187037601 0.141301370786013 no 2913 0.122174111071693 4293 2795021 SGTC_2211 7117706 200 µM -1.16511679607512 0.141106258106438 no 2914 0.121985859487294 4172 822771 SGTC_376 3970-0862 59.1 µM -1.16557399841874 0.141010379825834 no 2915 0.121893362823163 4291 3135186 SGTC_1966 st070145 16.1 µM -1.16611532297577 0.140896917714057 no 2916 0.121783911095996 4241 3748532 SGTC_3347 9188721 44.724 µM -1.17133397640619 0.139806259962858 no 2917 0.120732279736975 4284 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2656 pseudo-anisatin 100 µM -1.17138305671806 0.139796029876834 no 2918 0.120722419807127 4297 6708809 A neurotoxin. SGTC_557 1315-0110 16.2 µM -1.17181656183827 0.139705694057863 no 2919 0.120635355934218 4266 6833801 SGTC_2918 7977171 22.06 µM -1.17236199830513 0.139592089856991 no 2920 0.12052587491848 4243 2236483 SGTC_663 1486-0733 13.9 µM -1.17251503839591 0.139560225761567 no 2921 0.12049516900229 4277 722445 YPR165W RHO1 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.1725450151162 0.139553984962823 no 2922 0.120489155127737 4262 616764 SGTC_2417 cerulenin 830 nM -1.17366576370189 0.139320794548162 no 2923 0.120264464272602 4277 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_80 0159-0065 512.242 µM -1.17523989756309 0.138993717680699 no 2924 0.119949376182494 4187 1548079 SGTC_2956 9076196 2.52 µM -1.17648254722961 0.13873588680782 no 2925 0.119701051301986 4260 16423868 SGTC_400 oxethazaine 37.5 µM -1.17968813869584 0.138072280229101 no 2926 0.119062136578502 4267 4621 A local anesthetic. SGTC_1530 rhein 70.4 µM -1.17988411226969 0.138031781027313 no 2927 0.119023154826496 4328 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2622 2-methoxyxanthone 59.94 µM -1.18050818891533 0.137902865551299 no 2928 0.118899077721529 4253 71034 A hepatoprotective. SGTC_1287 0971-0001 34.6 µM -1.18163449497509 0.137670412511312 no 2929 0.118675380082656 4253 4665869 SGTC_2605 digitonin 300 nM -1.18181159546422 0.137633885913873 no 2930 0.118640232912891 4287 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3066 9117245 49.47 µM -1.18263402838233 0.137464347566935 no 2931 0.118477110158749 4317 17176980 SGTC_94 0334-0113 514.748 µM -1.18420692800474 0.137140503404222 no 2932 0.118165580177322 4288 6795178 SGTC_499 genistein 192 µM -1.18439810499364 0.137101177544008 no 2933 0.118127755002386 4376 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.18641537915515 0.136686685848884 no 2934 0.117729150613877 4249 442882 SGTC_1685 st024049 53.0905 µM -1.18887644696045 0.136182168684017 no 2935 0.117244144854954 4287 1941139 SGTC_47 0149-0135 24.25 µM -1.19067511594352 0.135814249846186 no 2936 0.116890575191299 4285 5239155 SGTC_1489 4065-0444 182 µM -1.19143429044254 0.135659164717246 no 2937 0.116741569056044 4277 2877968 SGTC_2237 6667747 47.222 µM -1.1914943489753 0.135646901064239 no 2938 0.116729786884686 4289 729940 YDL015C TSC13 SGTC_1193 1488-0126 41.5 µM -1.19229114627613 0.135484270902247 no 2939 0.116573552454672 4244 1384710 SGTC_555 4296-0685 37 µM -1.19331565588298 0.135275359976959 no 2940 0.116372886651555 4252 2908540 YHR072W ERG7 SGTC_1222 0366-0074 1.18 µM -1.19367679222048 0.135201772215537 no 2941 0.116302211050792 4297 286520 SGTC_1091 telmisartan 47.6 µM -1.1969778008282 0.134530406701204 no 2942 0.11565760372896 4317 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_560 2332-1943 155 µM -1.19726282813065 0.134472544816538 no 2943 0.115602064037958 4257 21177716 SGTC_2508 celastrol 40.54 µM -1.20036683001798 0.133843523931549 no 2944 0.114998452625267 4217 122724 Celastrol is a natural product and antioxidant. SGTC_3264 9137442 49.47 µM -1.2018611520423 0.13354142431765 no 2945 0.114708663940026 4268 17015726 SGTC_12 0849-0099 9.267 µM -1.20353745793271 0.133203092393138 no 2946 0.114384202569326 4207 6071388 SGTC_83 0170-0301 39.027 µM -1.20588722286211 0.132729828647715 no 2947 0.113930488937934 4293 3089716 SGTC_2677 mitomycin C 100 µM -1.20819170768142 0.132266810815197 no 2948 0.113486765332959 4350 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1659 st012954 42.1 µM -1.20958759837883 0.131986890093992 no 2949 0.113218589625393 4240 24207262 SGTC_1145 3546-0597 10.2 µM -1.209804401186 0.13194345088207 no 2950 0.11317697850372 4260 875334 SGTC_3151 9099821 49.47 µM -1.21101304767408 0.131701463844918 no 2951 0.112945202069233 4242 17174189 SGTC_2919 7978188 46.38 µM -1.21301085760784 0.131302147641477 no 2952 0.112562834685274 4317 2980291 SGTC_2641 levomentholum 100 µM -1.21516052473703 0.130873413348813 no 2953 0.112152436525111 4287 16666 SGTC_1125 tnp00248 1.32998 µM -1.21543602364394 0.130818537267609 no 2954 0.112099917778635 4344 24207736 SGTC_2865 9030313 51.95 µM -1.21760327628306 0.130387401147615 no 2955 0.111687384403954 4275 42562754 SGTC_3333 9141820 12.094 µM -1.22496229119387 0.128930796047038 no 2956 0.110294714307617 4282 1939433 SGTC_3146 9095609 49.47 µM -1.22815847908861 0.128301687730204 no 2957 0.109693740959253 4353 17173999 SGTC_943 3253-1379 105 µM -1.23059366789935 0.127823800335251 no 2958 0.109237437348523 4313 668464 SGTC_2431 5490079 200 µM -1.23214224786063 0.12752054743916 no 2959 0.10894797604239 4355 5722345 SGTC_1105 epirubicin 18.1 µM -1.23258210501877 0.127434503079336 no 2960 0.108865858370829 4337 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_306 1672-3436 11.6 µM -1.23512473510703 0.126937907972985 no 2961 0.108392042509259 4339 6797378 SGTC_1333 1482-0047 286 µM -1.23923064233601 0.126138839764841 no 2962 0.107630047865794 4321 3811116 SGTC_2506 ethyl hematommate 54.16 µM -1.24072988567016 0.125847941377992 no 2963 0.107352775080655 4369 3940691 An allergen. SGTC_1753 st043925 64 µM -1.24339711564121 0.12533157572938 no 2964 0.106860766327811 4351 670181 SGTC_1661 st013063 9.66 µM -1.24557334742678 0.124911362600673 no 2965 0.10646053610013 4394 721395 SGTC_2409 alverine citrate 63.97 µM -1.2497122133303 0.12411489877045 no 2966 0.105702347093778 4400 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1567 st069303 68.4 µM -1.2510893758321 0.123850673643242 no 2967 0.105450935618396 4361 5581319 SGTC_1591 genipin 88.4 µM -1.25227547866095 0.123623421401616 no 2968 0.105234750444127 4356 442424 A DNA cross-linking agent. SGTC_1345 1488-0192 31.4 µM -1.25263637624452 0.123554332940874 no 2969 0.105169035079348 4373 658348 SGTC_2733 amorolfine 100 µM -1.25300895196846 0.12348303724699 no 2970 0.105101224415997 4484 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2752 diclazuril 33.15 µM -1.25718304840971 0.122686256119117 no 2971 0.104343680059444 4263 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1772 st048439 82.2 µM -1.25839072197194 0.122456400961262 no 2972 0.104125242830854 4382 2927068 YDL195W SEC31 SGTC_1942 st076330 65.2 µM -1.2599990840785 0.122150752672536 no 2973 0.103834846327222 4390 24208414 SGTC_659 k018-0002 107 µM -1.26063289349379 0.122030452696743 no 2974 0.103720570897653 4297 6797879 YHR007C ERG11 SGTC_591 4299-0174 154 µM -1.26179256937578 0.121810556264906 no 2975 0.1035117183361 4359 5509088 SGTC_1588 farnesol 29.9 µM -1.2640285669028 0.121387355136767 no 2976 0.103109886867867 4351 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1433 4060-0023 7.6 µM -1.26775484046149 0.120684392450899 no 2977 0.102442756900895 4362 3840627 SGTC_2975 9084847 53.72 µM -1.2696476084171 0.12032842083771 no 2978 0.102105091413621 4354 27211724 SGTC_3121 9125696 49.47 µM -1.271037832029 0.120067433980286 no 2979 0.101857595000895 4454 1235365 SGTC_2456 5770359 74.46 µM -1.27475593495514 0.119371395092389 no 2980 0.101197820944791 4352 3118787 SGTC_1600 coumarin 106 71.1 µM -1.27980037348723 0.118431621719168 no 2981 0.100307676248778 4405 100336 A hepatotoxic, DNA x-linker. SGTC_1968 st069590 43.6 µM -1.27996431981707 0.118401166688887 no 2982 0.100278842366199 4310 6384066 SGTC_1442 4112-3290 3 µM -1.2801494510988 0.118366782951084 no 2983 0.100246289876404 4345 704353 SGTC_553 k007-0256 45.7 µM -1.28133441539217 0.118146871158914 no 2984 0.100038114792451 4403 6287000 SGTC_534 k292-0788 63.4 µM -1.28182858546082 0.118055245952963 no 2985 0.0999513920961982 4387 4146317 SGTC_1326 1431-2094 10.8 µM -1.28696880405244 0.117105165748368 no 2986 0.0990525808402098 4348 616278 SGTC_1672 st016598 6.51 µM -1.29230959303656 0.11612376545999 no 2987 0.0981249755628438 4330 4665860 YNL267W PIK1 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.295606007043 0.115520951845816 no 2988 0.0975556292575721 4421 4620898 SGTC_2621 lithochol-11-enic acid 100 µM -1.29874900609343 0.114948266907293 no 2989 0.097015040011707 4334 6708711 SGTC_3254 9136651 49.47 µM -1.30136472254211 0.114473199803434 no 2990 0.0965668214143934 4319 16454030 SGTC_1979 st071809 45.3 µM -1.30138759911267 0.114469051129099 no 2991 0.0965629080996406 4404 4976333 SGTC_922 1866-0035 480 µM -1.30183477173056 0.114387977706088 no 2992 0.096486437196037 4282 3156169 SGTC_1545 lovastatin 49.4 µM -1.30520073741986 0.113779032207311 no 2993 0.0959122515839902 4398 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2338 7999974 200 µM -1.30597575904251 0.113639148896385 no 2994 0.0957804006394362 4359 315925 SGTC_2105 5350118 200 µM -1.31107121498504 0.112722524602021 no 2995 0.0949168523584502 4341 2133313 SGTC_2651 TUB2.036 5 µM -1.31250542626503 0.112465478329831 no 2996 0.0946748281935982 4300 15992207 YFL037W TUB2 SGTC_2365 9042475 200 µM -1.31415672829009 0.112170042943529 no 2997 0.0943967335079147 4413 6464479 SGTC_2507 purpurin 79.67 µM -1.31576013680492 0.11188370742597 no 2998 0.0941272813994771 4371 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_313 3474-0040 5.03 µM -1.31956621318307 0.111206115055359 no 2999 0.0934899448155117 4383 1043375 YIL048W NEO1 SGTC_598 3937-0236 20.2 µM -1.32225926936743 0.110728450945369 no 3000 0.0930409153939122 4441 1379313 SGTC_2419 paclitaxel 166.5 µM -1.32533519582119 0.11018467833444 no 3001 0.0925300001937902 4332 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1358 1509-0022 2.48 µM -1.32544320093464 0.110165619698217 no 3002 0.0925120982056445 4407 3258434 SGTC_2490 carminic acid 95.39 µM -1.32970667163104 0.109415173641969 no 3003 0.0918074679088411 4348 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1754 st042065 16.137 µM -1.33065890217272 0.109248067064457 no 3004 0.0916506358500365 4149 1126236 YIL048W NEO1 SGTC_7 0192-1582 4.227 µM -1.33092143491945 0.10920202755497 no 3005 0.0916074317215991 4435 252616 SGTC_3063 1327-0034 4 µM -1.33186189656706 0.109037216292868 no 3006 0.0914527869824671 4266 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2303 7774051 200 µM -1.33506987939896 0.108476378288674 no 3007 0.0909267382895347 4393 2953184 SGTC_2097 5376186 200 µM -1.33681874567332 0.108171506976637 no 3008 0.0906409043596418 4376 742755 SGTC_2925 9010536 32.5 µM -1.33844865805493 0.107887928040886 no 3009 0.0903751131345009 4312 2994177 SGTC_1590 st077108 57.8 µM -1.33872424709552 0.107840032879049 no 3010 0.0903302298520694 4409 5489485 SGTC_1330 1469-0054 61.8 µM -1.34032192170286 0.10756267158594 no 3011 0.0900703537504755 4378 7102664 SGTC_2203 7227154 166.4 µM -1.34332437870749 0.107042827179244 no 3012 0.0895834807458669 4418 896304 SGTC_1602 st001878 87.6 µM -1.34463549921763 0.106816389540815 no 3013 0.0893714867637092 4378 595405 YLR310C CDC25 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.34563818344947 0.106643453901725 no 3014 0.089209615580353 4421 23847180 SGTC_674 0498-0004 451 µM -1.34828033576315 0.106188722877113 no 3015 0.0887841171689792 4379 4231473 SGTC_1264 0783-0040 158 µM -1.3508929957674 0.105740446572126 no 3016 0.0883648561192718 4323 2855798 SGTC_2058 5236698 133 µM -1.35105988193099 0.10571185904763 no 3017 0.0883381256329609 4366 766665 SGTC_2038 4100038 30.985 µM -1.35597007223932 0.104873244910532 no 3018 0.0875543452280152 4386 3596803 SGTC_2055 5235184 200 µM -1.35740184256481 0.104629621539518 no 3019 0.0873267815522917 4434 2836034 SGTC_2437 5741531 144.16 µM -1.36231823439599 0.103796192180762 no 3020 0.0865487377430074 4428 2262990 SGTC_1785 bathophenanthroline 24 µM -1.36486397910096 0.103366533393804 no 3021 0.0861479027528489 4331 72812 An iron chelator. SGTC_1634 st006576 41 µM -1.36670663247966 0.103056345531191 no 3022 0.0858586390600443 4395 3915356 SGTC_2618 avocadyne 43.43 µM -1.36689462905701 0.103024736685666 no 3023 0.085829167868069 4337 3015189 SGTC_2690 usnic acid 100 µM -1.36805664942841 0.102829516416763 no 3024 0.0856471723296918 4425 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1507 4075-3230 155 µM -1.37098967842088 0.102337961181652 no 3025 0.0851890868121392 4369 659771 SGTC_2880 9042983 58.44 µM -1.37177947073556 0.102205889999943 no 3026 0.0850660499894424 4368 6464714 SGTC_758 0868-0029 16 µM -1.37194453034876 0.102178303960684 no 3027 0.0850403532145291 4396 762687 SGTC_2236 dapsone 200 µM -1.3763861477191 0.101438019237458 no 3028 0.0843510571577952 4432 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_3022 9087993 49.47 µM -1.37911338353807 0.100985410791958 no 3029 0.0839298990182528 4503 17173644 SGTC_3172 9105863 49.47 µM -1.37999810686436 0.10083890000547 no 3030 0.0837936138603829 4513 2348785 SGTC_2974 9094440 9.66 µM -1.38208067483454 0.100494637271898 no 3031 0.0834734657468628 4411 25236134 SGTC_4 0960-0234 25.671 µM -1.38339785473827 0.100277341577152 no 3032 0.0832714539917963 4419 6821112 SGTC_1423 4048-0112 5.59 µM -1.38455292329936 0.100087071849863 no 3033 0.0830946074147353 4479 X1423 SGTC_2959 9079155 11 µM -1.38705919558903 0.0996751305989196 no 3034 0.0827118565571385 4443 16189457 SGTC_1995 st072814 61.1 µM -1.38962354703622 0.0992549268269906 no 3035 0.0823216107880448 4411 5769371 SGTC_2709 st078560 56 µM -1.39080446484619 0.0990618536055928 no 3036 0.0821423644141388 4403 17250903 SGTC_680 0417-1641 114 µM -1.39169522115211 0.0989164019643631 no 3037 0.0820073550258757 4451 2835990 SGTC_1325 1431-0015 227 µM -1.39356975062894 0.0986108204628398 no 3038 0.0817237841924877 4444 1103340 SGTC_587 k089-0003 57 µM -1.39380456570044 0.0985725902046824 no 3039 0.0816883145284828 4354 9659696 SGTC_1160 4092-0570 10.5 µM -1.39599532141584 0.0982164358358226 no 3040 0.0813579520178958 4438 4994975 SGTC_1279 0874-0590 65.2 µM -1.3978240023133 0.0979198670505955 no 3041 0.0810829623673694 4490 3523074 SGTC_1255 0566-0045 221 µM -1.3983409341584 0.0978361520394053 no 3042 0.0810053555542245 4455 2788469 SGTC_484 loperamide 105 µM -1.39943202234354 0.0976596269905772 no 3043 0.08084173490451 4512 3955 An opioid-receptor agonist. SGTC_351 caspofungin 25 nM -1.40132746780413 0.0973535219673161 no 3044 0.0805580854794328 4429 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_377 3970-0964 33.1 µM -1.40498558543582 0.0967647453256071 no 3045 0.0800127823320699 4437 16481235 SGTC_1191 1487-1166 10.6 µM -1.40524002528912 0.0967238905286699 no 3046 0.079974957911276 4462 3955771 SGTC_2816 7982706 58.44 µM -1.40722268543623 0.096405973428815 no 3047 0.0796806833995292 4436 2981853 SGTC_858 0438-0351 2.77 µM -1.4072511884092 0.0964014086178828 no 3048 0.0796764588528294 4416 2799119 SGTC_2092 5303694 80.6725 µM -1.41046446796036 0.0958878128780171 no 3049 0.0792012905504416 4454 1963699 SGTC_962 1254-0300 21.5 µM -1.41367278774082 0.0953770205845881 no 3050 0.0787289994024386 4416 7340576 SGTC_805 3852-0218 479 µM -1.41558246627073 0.0950739357463769 no 3051 0.0784488939479852 4425 6615355 SGTC_2007 4011539 71.82 µM -1.41662787543795 0.09490831974644 no 3052 0.0782958770712983 4396 45595301 SGTC_3188 9110789 49.47 µM -1.41702006005841 0.0948462438612982 no 3053 0.0782385313006267 4417 849217 SGTC_1510 1123-0200 71.5 µM -1.41775754486491 0.0947295940986234 no 3054 0.0781307815442862 4439 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_876 0720-0963 56.8 µM -1.42090150387037 0.0942334925085553 no 3055 0.0776726978757896 4462 765861 SGTC_2124 5246320 200 µM -1.42513086566186 0.0935691462060288 no 3056 0.0770596879771871 4456 579342 SGTC_3129 9127257 49.47 µM -1.42835057141102 0.0930657196982125 no 3057 0.0765954893078546 4390 837894 SGTC_367 0335-0881 7.1 µM -1.43346856571896 0.0922696055306697 no 3058 0.0758619879726529 4396 23828853 SGTC_1003 4049-0218 100 µM -1.43442592275352 0.0921212480314019 no 3059 0.0757253772342264 4456 295161 SGTC_1660 st012960 28.1 µM -1.43585625173664 0.0918999252362121 no 3060 0.0755216246690439 4484 24207266 SGTC_505 gw-5074 63.9 µM -1.4379059673429 0.0915834481787399 no 3061 0.0752303681680785 4475 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_617 3770-0098 35 µM -1.43793868221566 0.091578403543097 no 3062 0.0752257264667729 4377 5962639 SGTC_1394 3474-0001 65.7 µM -1.44257384512667 0.0908657407448866 no 3063 0.0745702777915922 4440 5017666 YIL048W NEO1 SGTC_1491 4138-0063 26.5 µM -1.44327428277763 0.0907584063395722 no 3064 0.0744716106561169 4471 23883227 SGTC_2251 lansoprazole 556 µM -1.44470862093443 0.090538903372601 no 3065 0.0742698736881058 4425 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_855 0428-0020 25 µM -1.44615581436649 0.0903178327801573 no 3066 0.0740667518859683 4478 6812414 SGTC_1391 3442-0225 151 µM -1.44679459263259 0.0902203818171375 no 3067 0.0739772308513851 4432 5227075 SGTC_1381 2324-0066 62.1 µM -1.44759272683552 0.0900987295601846 no 3068 0.0738654932241772 4481 10885928 SGTC_2485 5633444 17.78 µM -1.45158321450122 0.0894923236464588 no 3069 0.0733087643950768 4438 5724239 SGTC_783 0848-0141 92.7 µM -1.45788917908705 0.0885402476592096 no 3070 0.0724355458702648 4402 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2851 9015922 71.43 µM -1.46121045912626 0.0880418436692207 no 3071 0.0719788467971529 4487 2996893 SGTC_2228 7354201 200 µM -1.46172528528694 0.0879647745138503 no 3072 0.0719082526951347 4559 753451 SGTC_189 3970-0742 2.116 µM -1.46241268271362 0.08786194999215 no 3073 0.0718140780247957 4443 2891807 SGTC_1927 st060202 13.8 µM -1.4627130441683 0.0878170485003174 no 3074 0.0717729576800645 4403 688887 SGTC_2858 9025781 8.96 µM -1.46301519509896 0.0877718967683633 no 3075 0.0717316105746138 4317 4894980 YPL153C RAD53 SGTC_638 3970-0837 4.09 µM -1.46348405167136 0.0877018677732742 no 3076 0.0716674872194331 4458 4118451 YLR208W SEC13 SGTC_714 4296-0578 26.1 µM -1.46663683629933 0.0872320462048923 no 3077 0.071237436893227 4527 1589775 SGTC_3302 9125395 16.351 µM -1.46796107823452 0.0870352717420076 no 3078 0.0710573978226036 4429 17599668 SGTC_308 4092-1169 104 µM -1.47337961777298 0.0862335619688341 no 3079 0.0703243515310654 4447 2268590 YDL196W YDL196W SGTC_362 0310-0100 9.03 µM -1.47400109338897 0.0861419646678606 no 3080 0.070240648387892 4505 790235 SGTC_1419 3993-2473 62.6 µM -1.47462821406205 0.0860496091575226 no 3081 0.0701562626318479 4556 704026 SGTC_1204 4049-0315 18.3 µM -1.47798027823409 0.0855572095838309 no 3082 0.069706528535449 4509 588402 SGTC_846 0335-0850 148 µM -1.48071747489991 0.0851566979672817 no 3083 0.0693409376717129 4461 6819598 SGTC_3000 9075062 71.4286 µM -1.48368513962802 0.0847240529997796 no 3084 0.0689462352240124 4455 17057871 SGTC_1831 st055328 12 µM -1.48885413265452 0.0839744236390785 no 3085 0.0682628919893079 4475 1103068 SGTC_1829 berberine 14.4 µM -1.49481828393144 0.0831156782568494 no 3086 0.0674809366034092 4451 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2279 7948423 32.93 µM -1.49776623879796 0.0826936649868043 no 3087 0.0670969976390329 4435 1247112 SGTC_2190 6049624 200 µM -1.49925986062733 0.082480462614277 no 3088 0.0669031155647176 4389 2265554 SGTC_1104 tacrolimus 29.8 µM -1.50125104118989 0.0821968816878369 no 3089 0.0666453214004029 4557 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1407 3909-7909 12.3 µM -1.50502702085309 0.0816611301206067 no 3090 0.0661585649563235 4518 4411780 SGTC_428 3448-4153 16.5 µM -1.50829241873481 0.0811999483918124 no 3091 0.0657398513486106 4455 3834874 SGTC_1355 1499-0035 1.68 µM -1.5110818231822 0.0808075512869914 no 3092 0.0653838025941474 4505 1548538 SGTC_577 r071-0003 38.6 µM -1.51507074954587 0.0802489024066588 no 3093 0.0648772441074131 4467 4568517 YMR134W ERG29 SGTC_3098 9119039 49.47 µM -1.51598354835194 0.0801214763496514 no 3094 0.0647617562108541 4490 17161528 SGTC_568 1193-0097 7.48 µM -1.51611621362649 0.0801029691103743 no 3095 0.0647449846093385 4300 3646150 SGTC_2152 5568786 200 µM -1.51764562522466 0.07988984451777 no 3096 0.0645518792205465 4529 5399883 SGTC_1516 st013856 110 µM -1.52327455920694 0.0791091411703242 no 3097 0.0638450146376836 4521 5281404 A mutagen and neurotoxin. SGTC_1216 1165-0504 9.65 µM -1.52392990514248 0.079018624930775 no 3098 0.0637631110454115 4534 6304004 SGTC_2239 6685329 187.64 µM -1.52520265475559 0.078843057161016 no 3099 0.0636042793258843 4527 805680 SGTC_1701 st028638 40.4 µM -1.52657919403362 0.0786535051029289 no 3100 0.0634328419792722 4527 3490878 SGTC_3174 9107204 49.47 µM -1.52901038458096 0.0783195695222834 no 3101 0.0631309347779433 4515 3938802 SGTC_3038 9091290 49.47 µM -1.53056521031504 0.0781065711490748 no 3102 0.0629384426999881 4498 25236843 SGTC_1008 4106-0037 6 µM -1.53394298791798 0.0776453579671798 no 3103 0.0625218395651166 4537 2905394 SGTC_573 3702-0553 84.7 µM -1.53399602417406 0.0776381327403954 no 3104 0.0625153154456204 4453 1222756 SGTC_2315 7733312 200 µM -1.53613600676542 0.0773470246019184 no 3105 0.0622525134545906 4422 726316 SGTC_1822 st052468 42 µM -1.53766576641514 0.0771394356025321 no 3106 0.0620651790382545 4533 2873678 SGTC_2383 9036125 200 µM -1.54213279622848 0.076535680870606 no 3107 0.0615206633772799 4467 79580 SGTC_628 1636-0253 16 µM -1.54389746087623 0.0762981652953542 no 3108 0.0613065876640611 4509 4456143 SGTC_1494 4358-1428 177 µM -1.54415180124035 0.0762639785748639 no 3109 0.0612757810679628 4527 1564571 SGTC_1042 0350-0096 82 µM -1.54678650616639 0.0759105248102427 no 3110 0.0609573675566658 4503 3122515 SGTC_2389 9091542 195.52 µM -1.54886823246616 0.0756321380939487 no 3111 0.0607066994659017 4483 3626624 YOL127W RPL25 SGTC_2857 9024691 58.44 µM -1.54943690905872 0.0755562250940486 no 3112 0.0606383634780845 4542 16478292 SGTC_3290 9121031 71.43 µM -1.55536333917223 0.0747685539630804 no 3113 0.0599297800794656 4521 17014854 SGTC_2334 9017922 200 µM -1.55783707419319 0.0744416338267848 no 3114 0.0596359375030382 4545 3163164 SGTC_821 1114-0266 29.2 µM -1.55906264143048 0.0742800719631292 no 3115 0.0594907773490436 4550 3123235 SGTC_1454 4239-0054 42.6 µM -1.55990409109157 0.0741693019863588 no 3116 0.0593912737797706 4580 1340767 SGTC_1376 2910-0861 41.3 µM -1.56025347304956 0.0741233457918397 no 3117 0.0593499968257495 4457 1112859 SGTC_847 0342-0274 5.54 µM -1.56063269428651 0.0740734892878933 no 3118 0.0593052200350632 4513 18097 SGTC_1724 st037281 8.293 µM -1.56329584238999 0.0737240845797808 no 3119 0.0589915128861287 4477 574124 YDL195W SEC31 SGTC_1299 1079-1439 3.74 µM -1.56432923560945 0.0735888433031883 no 3120 0.0588701348723042 4513 323161 SGTC_1389 3405-0187 19 µM -1.57137943060828 0.0726712331679278 no 3121 0.058047270461942 4514 799890 SGTC_2394 5221648 200 µM -1.57262150969938 0.0725104835603884 no 3122 0.0579032420243748 4555 788586 SGTC_2911 7942208 15.64 µM -1.57615105327271 0.0720551774879579 no 3123 0.0574954978333855 4544 1243384 SGTC_3249 9135183 49.47 µM -1.57624374549584 0.0720432499274967 no 3124 0.057484820245842 4492 4902779 SGTC_1292 0kpi-0043 232 µM -1.5789746258961 0.0716925212689986 no 3125 0.0571709386331504 4544 3333905 SGTC_884 0851-0618 334 µM -1.58336861055311 0.071130950349474 no 3126 0.0566687365516072 4554 9642473 SGTC_549 1661-1316 519 µM -1.58341001069633 0.0711256753346817 no 3127 0.0566640213816912 4551 2857282 SGTC_1603 st002045 67.8 µM -1.58409072795418 0.0710389845585763 no 3128 0.0565865370369225 4524 5887985 SGTC_2206 7254556 146.969 µM -1.58538691413333 0.0708741369211736 no 3129 0.0564392262531342 4565 4398905 SGTC_190 3970-0790 3.722 µM -1.5865087491699 0.0707317004573462 no 3130 0.0563119745126602 4504 2832352 SGTC_1385 3091-4834 14.1 µM -1.58699821334534 0.070669623434554 no 3131 0.0562565246381836 4526 4072814 SGTC_2046 4110841 106 µM -1.58997298358185 0.0702932438874819 no 3132 0.0559204474488404 4547 44119630 YMR134W ERG29 SGTC_1366 1683-0113 21.9 µM -1.5941608716951 0.0697659909981771 no 3133 0.0554500039365865 4550 708623 SGTC_2039 Aminomethylbenzodioxan 200 µM -1.5952355229991 0.0696311849928811 no 3134 0.0553297889264907 4556 15053 SGTC_1880 MG-132 525 µM -1.59562686038336 0.0695821448371205 no 3135 0.0552860634378477 4510 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1702 st027038 51 µM -1.6096318136904 0.0678445725443991 no 3136 0.0537391293516985 4580 5521182 SGTC_2408 sulbentine 18.36 µM -1.61074307307591 0.0677081483460481 no 3137 0.05361786668645 4411 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1714 st033236 13.627 µM -1.61322528042979 0.0674041846006333 no 3138 0.0533477865033234 4541 2916566 SGTC_1853 st056710 91.2 µM -1.62112700147266 0.0664435833929921 no 3139 0.0524952021079395 4581 269167 SGTC_3197 9113331 49.47 µM -1.62119767506847 0.0664350397782982 no 3140 0.0524876256194019 4531 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_482 fipronil 114 µM -1.6216984427468 0.0663745271605854 no 3141 0.0524339662089832 4665 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_255 tunicamycin 200.472 nM -1.62188855776271 0.066351564898772 no 3142 0.0524136059761709 4473 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_171 k064-0041 9.68 µM -1.62244467138072 0.0662844323105302 no 3143 0.0523540854132937 4531 53325 SGTC_1360 1598-0022 39.8 µM -1.62428682583123 0.0660624279030336 no 3144 0.052157303793715 4574 761525 SGTC_2219 9098279 200 µM -1.62539284448041 0.0659294147891617 no 3145 0.0520394398017542 4506 902349 SGTC_1656 st012921 11 µM -1.62677708572973 0.0657632343143232 no 3146 0.0518922249825344 4480 6732821 SGTC_1854 st056233 32.9 µM -1.62798440331294 0.0656185590745828 no 3147 0.0517640964619315 4499 5393174 SGTC_1123 mangostin 811.285 nM -1.63257467128785 0.0650707500821302 no 3148 0.0512792409557903 4559 5281650 An antioxidant. SGTC_3059 1327-0034 3 µM -1.63736035108278 0.0645034064530917 no 3149 0.0507775987922892 4417 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2273 7815444 169.05 µM -1.64258128789363 0.0638888540640567 no 3150 0.0502347974658117 4501 2824616 SGTC_898 1000-0849 28.3 µM -1.64573498970655 0.0635198462742201 no 3151 0.0499091659571593 4563 6751807 SGTC_29 0299-0004 12.984 µM -1.64959356691592 0.0630706211548196 no 3152 0.0495130458209648 4490 16871 A napthoquinone isolated from Swertia calycina. SGTC_2291 7917025 104.35 µM -1.64988108088625 0.0630372473748803 no 3153 0.0494836304810143 4473 2964612 SGTC_2930 9013230 14.89 µM -1.65373483973472 0.0625912409846791 no 3154 0.0490907002594697 4535 2995857 SGTC_420 mitomycin C 81.9 mM -1.6538379620877 0.0625793402233445 no 3155 0.0490802202150871 4544 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2115 tiliquinol 12.7705 µM -1.66027884207203 0.0618395246947024 no 3156 0.0484291850460262 4552 71208 A bioactive hydroxyquinoline. SGTC_1220 1838-0075 193 µM -1.66498084695792 0.0613037649978207 no 3157 0.0479582885292005 4503 5529645 SGTC_532 1548-0774 215 µM -1.66506384481012 0.0612943406643127 no 3158 0.0479500094935734 4630 5932993 SGTC_688 0527-0193 473 µM -1.66787607323015 0.0609756830656729 no 3159 0.0476701651674769 4608 4007154 SGTC_191 3914-0123 66.505 µM -1.67210241904486 0.0604992272604152 no 3160 0.0472520638530602 4643 3144412 SGTC_1010 4112-3296 15.2 µM -1.67702664400843 0.0599477758959255 no 3161 0.0467686359070784 4599 704384 SGTC_566 0958-0068 16.5 µM -1.67848714823488 0.0597849769612753 no 3162 0.0466260186465089 4487 6815365 SGTC_268 camptothecin 39.6153 µM -1.67925090178615 0.0596999811953889 no 3163 0.0465515777057377 4532 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_749 1000-0129 128 µM -1.68748518841462 0.0587896149999547 no 3164 0.0457550478026451 4603 708470 SGTC_172 1112-0046 2.638 µM -1.68895425253248 0.0586283494984298 no 3165 0.0456140986024198 4572 2802135 YIL048W NEO1 SGTC_472 calcifediol 10 µM -1.69122204495105 0.0583800862100265 no 3166 0.0453972010737735 4616 5283731 A vitamin D metabolite. SGTC_2319 6033012 152.6 µM -1.69216695048318 0.0582768880419479 no 3167 0.0453070730310882 4528 847246 SGTC_1133 3473-0247 50 µM -1.69315429936892 0.0581692075629295 no 3168 0.0452130504474457 4555 711311 SGTC_869 0564-0080 44.1 µM -1.69889374553669 0.057546354767728 no 3169 0.0446696028428552 4582 6843321 SGTC_301 4119-0100 24.5 µM -1.69918555673065 0.0575148276870552 no 3170 0.0446421134393715 4600 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_397 arbidol 50 µM -1.70387449981407 0.0570100984282054 no 3171 0.0442022679674218 4603 131410 A RNA synthesis inhibitor. SGTC_3268 9137683 49.47 µM -1.704142980235 0.0569813044315147 no 3172 0.0441771893253467 4645 1953228 SGTC_1288 0973-0013 65.5 µM -1.7057316738779 0.056811154446817 no 3173 0.0440290247914185 4615 4315430 SGTC_3110 9122132 49.47 µM -1.70674948807926 0.056702356448011 no 3174 0.0439343123132971 4600 918317 SGTC_332 4112-0506 40.9 µM -1.71031776945386 0.0563222253189614 no 3175 0.0436035638172805 4591 2790355 SGTC_2181 6316240 54.2555 µM -1.71621341505243 0.055698563459843 no 3176 0.0430614943844551 4617 12779990 SGTC_837 0091-0265 12.5 µM -1.72719239190803 0.0545517052524528 no 3177 0.0420665583816733 4611 759367 SGTC_1295 1013-0063 9.78 µM -1.73171342622744 0.0540849030087079 no 3178 0.0416622994638099 4605 6826038 SGTC_1470 k295-0292 231 µM -1.73330350487436 0.0539214790051431 no 3179 0.041520869075091 4646 5045612 SGTC_504 lovastatin 124 µM -1.7339352032455 0.0538566633577346 no 3180 0.0414647904072896 4588 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2353 9059630 146.67 µM -1.73769254639289 0.0534724135947764 no 3181 0.0411325013901378 4638 4779114 SGTC_2823 7987624 58.44 µM -1.74746604057685 0.0524830842787782 no 3182 0.0402782653060064 4540 2239440 SGTC_473 2-arachidonoylglycerol 10 µM -1.75205384879057 0.0520237184363251 no 3183 0.0398822744902253 4476 5282280 An endocannabinoid. SGTC_405 ebelactone b 50 µM -1.75324022058562 0.0519054512806815 no 3184 0.0397803909099904 4578 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_57 miconazole 162.5 nM -1.75463687790594 0.0517664950756188 no 3185 0.0396607196539233 4460 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1852 st056254 31.4 µM -1.76443550457184 0.0507999067589351 no 3186 0.038829342484276 4596 442583 SGTC_2399 5884133 200 µM -1.76653093174694 0.0505950797115842 no 3187 0.0386534084585289 4548 722445 SGTC_1914 st062367 72.6 µM -1.77413361039054 0.0498574394498629 no 3188 0.0380205262320664 4582 978205 SGTC_757 1066-0008 322 µM -1.77518623282311 0.0497559895813585 no 3189 0.0379335710765765 4620 6842497 SGTC_122 0236-0016 402.397 µM -1.77827363171899 0.0494593812550738 no 3190 0.037679462426591 4598 6808838 SGTC_743 1275-0778 158 µM -1.78068022991159 0.0492291581294496 no 3191 0.0374823523362311 4597 2849257 YMR203W TOM40 SGTC_712 r015-0009 80.6 µM -1.78144223344487 0.0491564409989758 no 3192 0.0374201169868472 4656 6813872 YLR060W FRS1 SGTC_2304 7443016 91.4 µM -1.78201644672679 0.049101701177949 no 3193 0.0373732748726353 4576 939854 SGTC_329 k048-0121 21.3 µM -1.78776727854431 0.0485561554068645 no 3194 0.0369067810466355 4635 6832902 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.79482995307513 0.047892805887935 no 3195 0.0363403984705188 4593 5379071 SGTC_713 1488-1073 324 µM -1.79555914718875 0.0478247327734316 no 3196 0.0362823290180793 4652 3312542 SGTC_2897 9048598 12.99 µM -1.79659526170485 0.0477281407053296 no 3197 0.0361999485922828 4602 6467404 SGTC_3298 9116858 71.43 µM -1.81270335704256 0.0462464597493209 no 3198 0.0349387932218632 4659 2506942 SGTC_1320 1313-0481 95.3 µM -1.81444064650885 0.04608888868397 no 3199 0.0348049563811482 4600 6813365 YLR208W SEC13 SGTC_2021 4019055 173 µM -1.82280632429995 0.0453361554080975 no 3200 0.0341663647715178 4416 44827708 YER133W GLC7 SGTC_2342 7990637 118.86 µM -1.82836952074856 0.0448410834206176 no 3201 0.0337470562544922 4620 2033102 YER133W GLC7 SGTC_2136 5328288 199.296 µM -1.82887441635769 0.0447963687573312 no 3202 0.033709211816021 4603 262395 SGTC_2612 dictamnine 15.46 µM -1.83796245533285 0.0439976342677652 no 3203 0.0330339689400732 4546 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3273 9137859 49.47 µM -1.84297807554007 0.0435617610429624 no 3204 0.0326661058123827 4686 2377234 SGTC_1800 st050079 29.0735 µM -1.84344391008707 0.0435214560453196 no 3205 0.0326321119962992 4467 3645560 SGTC_1658 st012944 20 µM -1.84361914848264 0.0435063018393854 no 3206 0.0326193317013528 4500 24207260 SGTC_1632 st005650 90 µM -1.84771607610649 0.0431532213382513 no 3207 0.0323217135498589 4645 2759605 SGTC_2227 7312221 64.1025 µM -1.8676728921433 0.0414662695726486 no 3208 0.0309038396690651 4721 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1497 4476-2978 41.3 µM -1.87309619821339 0.0410171892485344 no 3209 0.0305275511302309 4685 1528379 SGTC_1715 st032160 10.2275 µM -1.87343930528421 0.0409889112346752 no 3210 0.0305038733278108 4566 5289825 SGTC_2020 4017018 200 µM -1.88308797705783 0.0402001457328614 no 3211 0.0298442231476901 4646 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2313 7726885 200 µM -1.88589569838514 0.039972948654139 no 3212 0.0296545056560741 4634 726423 SGTC_1788 fluconazole 20 µM -1.89269289363433 0.0394272478173476 no 3213 0.0291993610029451 4642 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_500 h-89 112 µM -1.89570729617609 0.0391871893808612 no 3214 0.028999380000462 4637 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3222 9128301 49.47 µM -1.89857631542823 0.0389598151379608 no 3215 0.0288101024670116 4599 4911358 SGTC_2534 helenine 20.12 µM -1.90452268930077 0.0384919761664448 no 3216 0.0284210722787491 4660 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2907 7721985 69.9 µM -1.9060609487204 0.0383716998780614 no 3217 0.0283211492599507 4651 3267881 SGTC_1067 clotrimazole 1.36 µM -1.90978630041547 0.0380816843241733 no 3218 0.0280803669478392 4699 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.91100887348573 0.0379868985956257 no 3219 0.0280017202885901 4669 94937 An inhibitor of serotonin biosynthesis. SGTC_823 0417-1665 178 µM -1.91153617544127 0.0379460764841247 no 3220 0.0279678562541146 4678 3429856 SGTC_1312 1218-2183 165 µM -1.91457250553049 0.0377117089822586 no 3221 0.0277735221446807 4698 6744073 SGTC_1472 k841-0093 193 µM -1.91658142230015 0.0375572957086758 no 3222 0.0276455650130677 4698 X1472 SGTC_2846 9008642 19.48 µM -1.92065523928037 0.0372457509398475 no 3223 0.0273875930669395 4652 2992898 SGTC_1707 st032323 6.317 µM -1.92381726278842 0.0370053937027551 no 3224 0.0271887464140003 4480 3132057 YMR211W DML1 SGTC_829 1635-0120 117 µM -1.93015675879338 0.0365273239597865 no 3225 0.0267937087587085 4648 285054 SGTC_2449 5812982 45.77 µM -1.93384152665984 0.0362517808361075 no 3226 0.0265663076453289 4603 776185 SGTC_197 4544-0043 41.561 µM -1.93760674039251 0.0359719821581907 no 3227 0.0263356097514585 4693 896523 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.9392736136738 0.0358486804501688 no 3228 0.026234015039117 4649 6708630 An antioxidant. SGTC_3015 9080845 49.47 µM -1.94535550234655 0.035401725347581 no 3229 0.025866103185039 4690 5296973 SGTC_1310 1188-0297 994 nM -1.94934977392797 0.0351106819843656 no 3230 0.0256268341273065 4571 1588352 SGTC_1002 4049-0206 172 µM -1.96322936322418 0.034114570578232 no 3231 0.0248097644588924 4660 4662749 SGTC_1464 k208-0027 110 µM -1.96995075509098 0.0336406061283091 no 3232 0.0244220073369782 4663 X1464 SGTC_574 1315-0397 40 µM -1.97283141487439 0.033439139725578 no 3233 0.0242573863639691 4663 6794277 SGTC_2516 gossypol 71.55 µM -1.97980097129174 0.0329558124819935 no 3234 0.0238629486031781 4680 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_77 0828-0286 12.516 µM -1.97996236892084 0.0329446883930868 no 3235 0.0238538786525354 4580 745345 SGTC_2833 9001315 45.46 µM -1.98924905093614 0.0323098106982203 no 3236 0.0233368601169358 4619 2989378 SGTC_887 0885-0007 9.62 µM -1.99116032808139 0.0321804083839558 no 3237 0.0232316318959746 4692 5719458 SGTC_1072 oxiconazole 14.9 nM -2.00021563943268 0.0315731239037268 no 3238 0.0227384918771192 4656 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1243 0416-0003 5.65 µM -2.00186927112751 0.0314632542105215 no 3239 0.022649396670923 4662 2141977 SGTC_2511 berberine 10.47 µM -2.00601907255329 0.0311889266211614 no 3240 0.0224271065740111 4680 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_346 4513-0042 7.16 µM -2.01120383076891 0.0308489651401288 no 3241 0.0221519656625178 4651 2827372 SGTC_1558 st069300 45.6 µM -2.01140769399186 0.0308356608745232 no 3242 0.0221412056649315 4679 24208000 SGTC_2735 sertaconazole 140 nM -2.01443527174473 0.0306386373230075 no 3243 0.0219819271491233 4761 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1884 5633444 25 µM -2.02153601645905 0.0301806344884432 no 3244 0.0216121539515607 4633 5724239 SGTC_1818 st052136 56.3 µM -2.02521886490475 0.029945332325257 no 3245 0.0214224476969327 4386 674169 SGTC_931 2812-0076 566 µM -2.02673800220902 0.0298487168151718 no 3246 0.021344606925491 4640 3450959 SGTC_966 1300-0360 30.2 µM -2.0271976095811 0.0298195372778382 no 3247 0.0213211037665028 4673 70588 SGTC_696 1560-0013 611 µM -2.02889780879553 0.0297118006948271 no 3248 0.0212343500035812 4691 1650269 SGTC_2104 5389443 200 µM -2.02891928247269 0.0297104420397191 no 3249 0.0212332562073895 4699 2244536 SGTC_2586 curcumin 80 µM -2.02958905036176 0.0296680912127067 no 3250 0.021199164420307 4593 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1157 4092-0394 27.6 µM -2.03007504608446 0.0296373920587615 no 3251 0.0211744557983865 4711 3659885 SGTC_2876 9059903 25.97 µM -2.05403157894472 0.0281564766012148 no 3252 0.0199863176992745 4692 6916095 SGTC_1731 st035964 63 µM -2.05519493851015 0.0280861588414787 no 3253 0.0199300899101926 4602 6739575 SGTC_2369 9071472 200 µM -2.0565585232438 0.0280039249335459 no 3254 0.0198643556998674 4703 17296037 SGTC_1734 st037168 69.4 µM -2.06095700063222 0.0277400307769588 no 3255 0.0196535712539188 4679 708907 SGTC_1587 estradiol valerate 56.1 µM -2.06619271959203 0.0274286095872248 no 3256 0.0194051430122776 4729 13791 A steroid. SGTC_2885 9057732 51.95 µM -2.067989367651 0.0273224188508109 no 3257 0.0193205114533457 4692 6471414 SGTC_335 4077-0256 27.6 µM -2.08452446508348 0.0263611195479875 no 3258 0.0185562436086763 4608 3121989 SGTC_1787 fluconazole 80 µM -2.08468462393896 0.0263519484587442 no 3259 0.0185489686394259 4357 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1657 st012939 43.4 µM -2.08769499392466 0.0261800628428971 no 3260 0.0184126783567995 4712 24207257 SGTC_2560 caryophyllene 100 µM -2.08937593937957 0.0260844930526559 no 3261 0.0183369476777534 4721 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -2.09420048494152 0.0258118137664673 no 3262 0.0181210623010139 4710 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1951 sophoraflavanone G 9.2 µM -2.10029468664753 0.0254707881589424 no 3263 0.0178514631942535 4656 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2162 5663267 200 µM -2.1013406850281 0.0254126361991681 no 3264 0.0178055353645822 4708 6456493 SGTC_2896 9052656 71.43 µM -2.12963021240389 0.0238815631667511 no 3265 0.0166010773547459 4366 6469436 SGTC_612 0302-0167 22.4 µM -2.16292363282604 0.0221797291402772 no 3266 0.0152735268781644 4706 235821 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -2.1703093096284 0.0218163995243022 no 3267 0.0149917109184479 4705 2374 Ca(2+)-ATPase inhibitor. SGTC_1147 3809-1045 12.3 µM -2.1757882552247 0.0215501282843956 no 3268 0.0147855486501333 4726 325925 SGTC_1529 apigenin 74 µM -2.18663728493999 0.0210309748486898 no 3269 0.0143845066145165 4724 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1496 4469-0713 57.4 µM -2.19704478652907 0.0205429346894334 no 3270 0.0140086238853318 4747 746691 SGTC_3078 9116413 49.47 µM -2.20417989306656 0.0202139197837882 no 3271 0.013755847626637 4704 17177322 SGTC_1741 st038134 10.228 µM -2.21214660151445 0.0198518481325327 no 3272 0.0134782685239616 4707 1272587 SGTC_2036 5160441 105 µM -2.22610888642051 0.0192305616992908 no 3273 0.0130034444284434 4705 134534 YIL048W NEO1 SGTC_2875 9039966 71.43 µM -2.22821246935125 0.0191384053440857 no 3274 0.0129331749753821 4730 6463691 SGTC_2323 6148992 148.28 µM -2.25042884766513 0.0181878330092378 no 3275 0.012210867744674 4701 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1826 st055655 41.6 µM -2.25855767080279 0.0178502260623201 no 3276 0.0119554566926443 4724 676168 SGTC_715 0868-0130 184 µM -2.2732315806171 0.0172543140928466 no 3277 0.0115061140664827 4769 2876258 SGTC_3304 9125678 46.087 µM -2.27776611633946 0.0170736374357956 no 3278 0.0113702580636306 4714 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1520 flindersine 88 µM -2.28010561089781 0.0169810553000689 no 3279 0.0113007127682618 4722 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3002 9075603 71.4286 µM -2.30325238701042 0.0160879561422341 no 3280 0.0106323234265765 4706 20105405 SGTC_1745 st081495 74 µM -2.3125621016709 0.0157402684549997 no 3281 0.0103733636135757 4636 13842402 YBL026W LSM2 SGTC_572 0960-0087 17.7 µM -2.32074608463528 0.0154399663219187 no 3282 0.0101502759541258 4729 6796365 SGTC_2938 9059746 27.26 µM -2.32371729780653 0.0153321646402931 no 3283 0.010070325374243 4713 6471769 SGTC_669 0108-0021 26.2 µM -2.32862086577159 0.0151556667192979 no 3284 0.00993957983798612 4723 17201 SGTC_3091 9116372 49.47 µM -2.33806546865244 0.0148206349680688 no 3285 0.00969192610041459 4759 17169793 SGTC_1262 0737-0114 49.6 µM -2.34945811877141 0.014424992215771 no 3286 0.00940037951868053 4748 765919 SGTC_3025 9087895 49.47 µM -2.35113771811147 0.0143674393021275 no 3287 0.00935805263628894 4745 17173641 SGTC_1196 1588-0294 184 µM -2.35791852306923 0.0141370952424352 no 3288 0.00918886304371128 4766 6144269 SGTC_1534 6-azauridine 81.6 µM -2.38133333087363 0.0133659934387565 no 3289 0.00862504742252013 4768 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_160 3453-0671 289.699 µM -2.39503091108443 0.0129319584255217 no 3290 0.0083094820751954 4727 5322268 SGTC_2779 methotrexate 400 µM -2.41294907107317 0.0123826235475292 no 3291 0.00791201525408453 4728 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_285 1486-1325 46 µM -2.44486919545032 0.0114539857059258 no 3292 0.00724523428287568 4769 22310230 SGTC_419 nsc-638432 893 µM -2.44815012187899 0.0113620550797522 no 3293 0.00717959068630134 4752 368090 SGTC_382 3229-0966 23.2 µM -2.46964661815859 0.0107754426824358 no 3294 0.00676232912838646 4774 5722370 SGTC_1070 indatraline 8.81 µM -2.50448830250103 0.00988060290090085 no 3295 0.00613143300793645 4770 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_955 1216-0110 33 µM -2.50619460750338 0.00983849758943024 no 3296 0.00610192151737481 4735 3619719 SGTC_300 r073-0011 5.04 µM -2.51043678963785 0.00973449461824746 no 3297 0.00602909539730569 4774 2735780 SGTC_994 3910-0338 138 µM -2.52979461015003 0.00927200938582652 no 3298 0.00570646569962159 4781 3479481 SGTC_875 0709-0210 25.7 µM -2.5598939606921 0.00859106826641485 no 3299 0.00523520529161428 4761 6251364 SGTC_1814 st052110 31.539 µM -2.58052764533163 0.00814999409093894 no 3300 0.00493247286946742 4747 674163 SGTC_3340 9146634 11.102 µM -2.58219249739615 0.00811528876839533 no 3301 0.00490874040878277 4759 4907387 SGTC_2867 9039098 71.43 µM -2.58606649431284 0.00803503413995051 no 3302 0.00485391002770162 4758 6463460 SGTC_2482 5981709 142.65 µM -2.60053287838702 0.00774147906230214 no 3303 0.00465395496512479 4744 877755 SGTC_2575 plumbagin 510 nM -2.62689437913127 0.00723074322024707 no 3304 0.00430840378665658 4714 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2385 9074692 200 µM -2.65813366874 0.00666415879452054 no 3305 0.00392873608537739 4772 17046906 SGTC_3055 9094636 49.47 µM -2.66062534121103 0.00662070470373748 no 3306 0.00389978456265585 4764 25236176 SGTC_3092 9117248 49.47 µM -2.66257103328916 0.00658694673635489 no 3307 0.00387731002545759 4802 17141857 SGTC_151 3013-0144 2.285 µM -2.66593239890585 0.00652898515299166 no 3308 0.00383875646950773 4597 906558 YHR107C CDC12 SGTC_1248 0469-0687 58.6 µM -2.68295190862303 0.00624238000244632 no 3309 0.00364877417115628 4752 4017482 SGTC_1711 st032263 62.8 µM -2.70786813890644 0.00584288814865435 no 3310 0.00338584607075021 4785 3958979 SGTC_3087 9117406 49.47 µM -2.71098317199466 0.00579457347543136 no 3311 0.00335420153800201 4764 42546093 SGTC_280 3448-3607 3.04 µM -2.74220641457375 0.00532953636429226 no 3312 0.00305139888838843 4763 626179 SGTC_2157 5649910 96.377 µM -2.76112790179248 0.00506415125943646 no 3313 0.0028801056611562 4764 2858091 SGTC_3288 9119690 36.221 µM -2.79808656190575 0.00457949532815575 no 3314 0.00257031669286977 4773 17595618 YKL019W RAM2 SGTC_3203 9113543 49.47 µM -2.81800921939138 0.00433579803337514 no 3315 0.00241612111539734 4762 17018012 SGTC_686 1319-0111 510 µM -2.82865540109119 0.00421038202764814 no 3316 0.00233720004041504 4778 4562600 SGTC_919 tnp00227 403.569 nM -2.83669620548045 0.00411781960163933 no 3317 0.00227914806765641 4753 1269246 A methoxyflavone. YNL221C POP1 SGTC_1673 st016611 27.3 µM -2.84229087612304 0.00405449467288985 no 3318 0.00223953026234295 4773 5226799 SGTC_293 4049-0273 38.5 µM -2.84702250822686 0.00400162020890227 no 3319 0.00220651210244443 4749 1380311 SGTC_1842 st055362 61.2 µM -2.85367294528521 0.00392834749406047 no 3320 0.00216084987747922 4781 676032 SGTC_1718 roemerine 11.9335 µM -2.85736854636273 0.00388815195674558 no 3321 0.00213584765634468 4533 235224 An aporphine alkaloid with mutagenic activity. SGTC_2404 5161160 200 µM -2.8598422035852 0.00386145328883447 no 3322 0.00211925925160325 4767 2831543 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -2.88470401749668 0.00360210032224712 no 3323 0.00195890906500946 4748 5355888 SGTC_1815 st051655 58.2 µM -2.89602567325111 0.0034892631633832 no 3324 0.00188960740338162 4787 5984156 SGTC_340 k038-0059 454 µM -2.90383418846674 0.00341330018183669 no 3325 0.00184311664257155 4796 23733424 SGTC_1774 st048371 48.465 µM -2.90545147515713 0.00339775387183181 no 3326 0.00183361853639714 4782 4242727 SGTC_2240 6690706 185.951 µM -2.92426139895901 0.00322155952897607 no 3327 0.00172637333413277 4759 805876 SGTC_3266 9136860 49.47 µM -2.92676530579517 0.00319873587093388 no 3328 0.00171253618724243 4630 4871271 YPR165W RHO1 SGTC_1311 1190-0148 100 µM -2.94734736203647 0.00301657040030106 no 3329 0.00160256470985901 4800 1961333 SGTC_2188 6126565 140.678 µM -2.96070102751028 0.00290343552119327 no 3330 0.00153469868129715 4769 874518 SGTC_2804 7954240 19.48 µM -2.98065799014683 0.00274147837688442 no 3331 0.00143814913504048 4774 828705 SGTC_348 k064-0012 10.7 µM -3.01942575745103 0.00244997220703824 no 3332 0.00126627177649402 4789 5066323 SGTC_2305 7443522 69.23 µM -3.02786865263266 0.00239033124208781 no 3333 0.00123142554487292 4759 5415886 SGTC_1250 0485-0349 40.2 µM -3.03639621999135 0.00233142891886738 no 3334 0.00119712256760361 4773 6842794 YDL195W SEC31 SGTC_162 k030-0015 37.8 µM -3.04960137817347 0.00224280702986139 no 3335 0.0011457264088703 4792 1809920 YMR134W ERG29 SGTC_281 1672-3440 14.9 µM -3.05498780341019 0.0022075427943435 no 3336 0.00112534837379938 4797 6833000 SGTC_2155 5570423 76 µM -3.11415884267246 0.00185193691037236 no 3337 0.000922350749378883 4785 797402 SGTC_320 4092-0846 5.34 µM -3.19507643843053 0.00144978586074847 no 3338 0.000698969052567209 4780 1359356 SGTC_2777 climbazole 1.536 µM -3.2639713060397 0.00117206083486895 no 3339 0.000549311456087507 4692 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1239 0337-0584 35.4 µM -3.26774823047978 0.0011583464391788 no 3340 0.000542033773277232 4800 914301 YML130C ERO1 SGTC_2592 piperlongumine 83.33 µM -3.37500198408855 0.000825209170262937 yes 3341 0.000369075793385378 4786 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2166 5933061 31.504 µM -3.41562049197981 0.000723968429215889 yes 3342 0.000318184342592804 4773 2877375 SGTC_1244 0416-0015 52.5 µM -3.47994318012955 0.00058680998872935 yes 3343 0.000250760066990361 4795 96201 SGTC_965 1291-5240 308 µM -3.74593368078271 0.000237433586496237 yes 3344 8.98620351159113e-05 4798 2834598 SGTC_339 3091-4833 71.4 µM -3.80400654923114 0.000193361201707722 yes 3345 7.11872065437403e-05 4760 3240077 SGTC_2597 laccaic acid a 100 µM -3.82267941585153 0.000180899945671446 yes 3346 6.60046804260838e-05 4796 5491415 A textile dye. SGTC_2815 7968870 71.43 µM -3.85414240679314 0.000161587129966004 yes 3347 5.80679936017592e-05 4792 2977326 YHR190W ERG9 SGTC_3104 9120930 49.47 µM -3.87685139919512 0.000148865959328943 yes 3348 5.290847060576e-05 4805 17014836 SGTC_374 0880-0231 82.3 µM -4.11102325242359 6.23311811653948e-05 yes 3349 1.96954762345237e-05 4790 6833587 SGTC_352 k048-0007 5.11 µM -4.1232744312146 5.94809951880532e-05 yes 3350 1.86762116575125e-05 4789 6811911 SGTC_453 enantio-paf c16 10 µM -4.30287632956307 2.95207643870009e-05 yes 3351 8.42974832574117e-06 4600 13871343 A lipid and platelet activating factor SGTC_384 k007-0144 5.16 µM -4.40418473924539 1.96486494027174e-05 yes 3352 5.3091215447788e-06 4806 6824886 SGTC_309 k408-0051 1.48 µM -4.57879175659254 9.54638556815433e-06 yes 3353 2.33834752883896e-06 4801 3640463 SGTC_304 1310-0298 97 µM -4.73974415744786 4.79723296633076e-06 yes 3354 1.06994120359674e-06 4773 1550234 SGTC_2811 7967822 32.47 µM -5.39091899646684 2.37048852007845e-07 yes 3355 3.50491347265056e-08 4809 2232244 SGTC_431 k089-0097 107 µM -6.50727312676064 5.89962613887023e-10 yes 3356 3.8263600170643e-11 4790 5499420