SGTCid condition conc unit YNL108C|YNL108C.score YNL108C|YNL108C.strain.pval YNL108C|YNL108C.strain.significant YNL108C|YNL108C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2942 9052777 62.25 µM 9.74833663445447 2.3827253344757e-19 yes 1 9.37577121732446e-23 1 6469503 SGTC_975 1335-0046 28.5 µM 5.7742509558901 6.43682925654849e-08 yes 2 3.86480807571563e-09 10 16486740 SGTC_3247 9135149 49.47 µM 5.73031445195056 8.01030657164245e-08 yes 3 5.01223137037741e-09 14 8934436 YOR116C RPO31 SGTC_1747 st037496 66.6 µM 5.39906992616984 3.96094484616529e-07 yes 4 3.34936313576442e-08 6 723305 SGTC_285 1486-1325 46 µM 5.36050400075422 4.74358949653605e-07 yes 5 4.14950444695738e-08 12 22310230 SGTC_1323 1348-1351 11.2 µM 5.30850602144415 6.03756455421852e-07 yes 6 5.52637173704162e-08 1 6989654 SGTC_632 0781-2353 4.65 µM 5.24978260458469 7.90721622821685e-07 yes 7 7.6139407467795e-08 15 6811515 YHR007C ERG11 SGTC_1909 st060837 51.5 µM 5.1461186255423 1.26442910087368e-06 yes 8 1.32965646350557e-07 27 678937 SGTC_1521 st012942 49.4 µM 4.77789835610225 6.2463879791537e-06 yes 9 8.85684392788277e-07 16 24207259 SGTC_2926 9010726 65.15 µM 4.74036118085464 7.30614830087405e-06 yes 10 1.06668788886904e-06 18 2994293 SGTC_52 0329-0193 875 nM 4.68830327305347 9.06280501267912e-06 yes 11 1.37739781189054e-06 17 3739292 SGTC_1752 st044819 83.042 µM 4.6878955970922 9.07803193953065e-06 yes 12 1.38014382856817e-06 13 441209 YML126C ERG13 SGTC_208 k072-0098 12.366 µM 4.60546832095184 1.2711941573033e-05 yes 13 2.05769317406574e-06 28 5948901 SGTC_2951 9072950 58.06 µM 4.47508199032527 2.14131396605212e-05 yes 14 3.81909980503589e-06 15 16488155 SGTC_970 1315-0089 19.5 µM 4.43266544546385 2.52976537289938e-05 yes 15 4.65376156185141e-06 14 6811083 YLR033W RSC58 SGTC_1915 st067105 30.6 µM 4.42384518608651 2.61852612365219e-05 yes 16 4.84797564143642e-06 26 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_706 4262-0057 46.9 µM 4.41991060278078 2.6590656851058e-05 yes 17 4.93708700980109e-06 19 883298 SGTC_1034 k072-0165 12.7 µM 4.28013076511154 4.55282401587746e-05 yes 18 9.33917670586836e-06 15 5835461 SGTC_1272 0839-0021 27 µM 4.14098214831275 7.65702302917918e-05 yes 19 1.72910938630903e-05 14 5027250 SGTC_1482 3346-2049 8.48 µM 4.08451843429687 9.41388182527973e-05 yes 20 2.20841600681983e-05 26 3826804 SGTC_622 1348-1566 26.3 µM 4.03953939260146 0.00011077555085071 yes 21 2.67781364401498e-05 18 7340407 SGTC_957 1187-1561 14.1 µM 4.01845116440289 0.000119492206182583 yes 22 2.92909736704945e-05 17 1538454 SGTC_2128 5255449 168.493 µM 3.93053610591504 0.000163240984576926 yes 23 4.23783319520588e-05 35 736008 SGTC_638 3970-0837 4.09 µM 3.90582020928523 0.000178008676345294 yes 24 4.69531576614961e-05 39 4118451 YLR208W SEC13 SGTC_1960 st011366 51.8 µM 3.79520043415863 0.000260740672115773 yes 25 7.37621129590607e-05 12 3972846 SGTC_2871 9038510 12.99 µM 3.77140931091604 0.000282691146640854 yes 26 8.11640768794792e-05 26 4945164 SGTC_2933 9026794 32.47 µM 3.70105052088702 0.000358089231521542 yes 27 0.000107354359142341 27 17586027 SGTC_931 2812-0076 566 µM 3.62748131577017 0.000456609451105639 yes 28 0.000143099739268973 35 3450959 SGTC_3012 9080433 71.4286 µM 3.62696051179074 0.000457388805781689 yes 29 0.000143388565386143 19 17688859 SGTC_2712 st079126 47.7 µM 3.59728802780109 0.000503883189803459 yes 30 0.000160776176300489 24 3152970 SGTC_2796 7949634 45.45 µM 3.57969596660365 0.000533476218289321 yes 31 0.000171997099982913 30 2971588 SGTC_1635 st007035 42.4 µM 3.56963574352134 0.000551113863440748 yes 32 0.000178738972890712 244 3716403 SGTC_2809 7964133 12.99 µM 3.56449146289995 0.000560339778416062 yes 33 0.000182281158134014 53 1253665 SGTC_1288 0973-0013 65.5 µM 3.53606886254821 0.000613939312360717 yes 34 0.000203064406740376 27 4315430 SGTC_1285 0929-0069 65.5 µM 3.51101089284766 0.00066508121265205 yes 35 0.000223203052958675 35 1206237 SGTC_2512 diallyl trisulfide 49.23 µM 3.4885004976816 0.000714346378228981 yes 36 0.000242868958687821 16 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_599 1935-0052 86.5 µM 3.48412069309419 0.000724314324567556 yes 37 0.000246878388284909 26 9557311 SGTC_1392 3455-1037 33.9 µM 3.40826072615993 0.00091860932606158 yes 38 0.000326891971407212 32 981132 SGTC_2947 9072639 7.68 µM 3.40146335979932 0.000938173023483671 yes 39 0.000335130564684518 68 16488146 SGTC_1238 0333-0287 48.8 µM 3.39945807805709 0.000944017167182222 yes 40 0.00033759764781957 41 7226 SGTC_2856 9022925 19.48 µM 3.37411365663359 0.00102081878527802 no 41 0.000370268925641946 42 4944862 SGTC_3315 9136395 68.55 µM 3.31984326449953 0.00120490914525494 no 42 0.000450339999628153 23 16876844 SGTC_2414 st077232 92.9 µM 3.29436981477041 0.00130139299133946 no 43 0.000493213129294557 43 729801 SGTC_2612 dictamnine 15.46 µM 3.2584973481799 0.00144926406302435 no 44 0.000560019615578469 75 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_637 1181-0519 7.26 µM 3.25793114556064 0.00145171630773685 no 45 0.00056113816597108 142 6252091 YGR060W ERG25 SGTC_362 0310-0100 9.03 µM 3.2410063182661 0.00152678997414951 no 46 0.000595542719557527 68 790235 SGTC_2718 lomofungin 53.02 µM 3.23964337358458 0.00153298704624388 no 47 0.00059839640841576 38 5351222 A RNA synthesis inhibitor. SGTC_3159 9100096 49.47 µM 3.18171939957646 0.00181854056534833 no 48 0.000732017934534239 46 25236875 SGTC_676 falcarinol 140 µM 3.15621787740858 0.0019589563567584 no 49 0.000799147111225545 91 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_829 1635-0120 117 µM 3.10653324942477 0.00226115110799122 no 50 0.000946475097400636 76 285054 SGTC_936 3005-4620 401 µM 3.04501700503984 0.00269352983917205 no 51 0.0011633357713977 70 777207 SGTC_479 n-linoleoylglycine 10 µM 3.03221916417873 0.00279236136065075 no 52 0.00121381437083388 32 6433346 An anti-infammatory. SGTC_1567 st069303 68.4 µM 3.03178658042941 0.00279575844195689 no 53 0.00121555512207798 66 5581319 SGTC_1328 1441-0025 69.2 µM 3.02189655862114 0.00287444895498828 no 54 0.00125598186081913 35 4562601 SGTC_816 0325-0417 81.3 µM 2.97302630795716 0.00329337833179523 no 55 0.00147439587790398 50 68101 SGTC_1741 st038134 10.228 µM 2.95085091308603 0.00350097795450938 no 56 0.00158449919506998 81 1272587 SGTC_2676 harmalol 100 µM 2.94793177847955 0.00352916395649774 no 57 0.00159953827329993 45 5459187 A monoamine oxidase inhibitor SGTC_3052 9092717 49.47 µM 2.88720461412233 0.00416363354231638 no 58 0.00194340686651216 90 25237534 SGTC_1093 fluphenazine 7.97 µM 2.8771180477591 0.00427837820032852 no 59 0.00200662715226336 66 6602611 An atypical antipsychotic. SGTC_150 3970-0969 77.2 µM 2.8713064862611 0.00434576669794772 no 60 0.00204389489629472 144 6615640 SGTC_1329 1447-1697 50.6 µM 2.86202275596155 0.00445538652742222 no 61 0.00210473341249976 59 2840515 SGTC_770 0389-1121 67.2 µM 2.82706389979686 0.00489066447328006 no 62 0.00234884764057458 81 6753108 SGTC_1062 mesoridazine 14.2 µM 2.8171620511421 0.00502065454763253 no 63 0.00242250365825259 75 4078 A neuroleptic. SGTC_274 sirtinol 40.1 µM 2.79491339031424 0.00532401670374064 no 64 0.00259568105539929 79 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_450 aminopyrene 156 nM 2.77361670003444 0.00562955734188862 no 65 0.00277184764764376 103 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1018 4259-0013 28.1 µM 2.76899990385764 0.00569781218876569 no 66 0.00281143259079915 72 6801262 SGTC_631 k072-0230 41.5 µM 2.7670562960876 0.00572676559251581 no 67 0.00282824931592784 80 5773147 SGTC_1041 0206-0046 107 µM 2.75964502136121 0.00583837131803441 no 68 0.00289320991734464 91 50494 SGTC_589 1227-0070 34.1 µM 2.75883668635931 0.00585065991140833 no 69 0.00290037581388313 78 2841384 SGTC_580 1123-0028 41 µM 2.75241546904389 0.00594909536728344 no 70 0.00295787082874511 119 1677248 YPR107C YTH1 SGTC_1787 fluconazole 80 µM 2.75104798893653 0.00597024714150518 no 71 0.00297024700323431 124 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 2.72684738180676 0.00635576571700004 no 72 0.00319713033050084 83 6312947 SGTC_282 k297-0036 65.7 µM 2.72131733780234 0.00644689342758129 no 73 0.00325111544485584 49 5061378 SGTC_1814 st052110 31.539 µM 2.72065097452112 0.00645795187116908 no 74 0.00325767563235913 50 674163 SGTC_1259 0671-0132 43 µM 2.70822696774965 0.00666722666966585 no 75 0.00338218723044686 95 X1259 SGTC_3072 9116419 49.47 µM 2.69947106176375 0.00681829374124141 no 76 0.00347248977149583 87 17170162 SGTC_1470 k295-0292 231 µM 2.66515870215236 0.00743982733381528 no 77 0.00384759990192297 71 5045612 SGTC_1465 k213-0056 144 µM 2.66329394481449 0.00747499218605535 no 78 0.00386898934762422 92 24048857 YMR208W ERG12 SGTC_947 3447-0010 211 µM 2.65116007994476 0.00770740482053389 no 79 0.00401079061069919 90 748350 SGTC_641 4092-0595 30 µM 2.64286915377091 0.00786984521717514 no 80 0.00411033985541141 85 786260 SGTC_2974 9094440 9.66 µM 2.63314461396091 0.00806420499529037 no 81 0.00422991591303643 134 25236134 SGTC_2119 5528445 120.635 µM 2.62684305491946 0.0081923927228025 no 82 0.00430905364845607 100 791935 SGTC_1368 1852-0141 284 µM 2.61167301344788 0.00850835255013868 no 83 0.00450501925005873 124 2838987 SGTC_1436 4092-1007 8.32 µM 2.60841719456033 0.00857754164798902 no 84 0.00454810082511809 76 2881121 SGTC_2092 5303694 80.6725 µM 2.59007988895787 0.00897651909748849 no 85 0.00479768305542762 131 1963699 SGTC_1105 epirubicin 18.1 µM 2.58945823351804 0.00899032518614943 no 86 0.00480635415534424 90 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3223 9129970 49.47 µM 2.58444125024119 0.00910242771160362 no 87 0.00487684600139641 102 17248386 SGTC_3273 9137859 49.47 µM 2.56922376210053 0.00944997675293846 no 88 0.00509633093360282 50 2377234 SGTC_2864 9034755 47.6 µM 2.55674015480263 0.00974369716360773 no 89 0.00528290550647254 96 4930451 SGTC_195 4234-0266 16.654 µM 2.55511900125974 0.00978241960309046 no 90 0.00530757499769703 129 2303354 SGTC_2484 5809818 12.04 µM 2.55441241576948 0.00979933893338341 no 91 0.00531835930305049 86 2870548 SGTC_929 2805-0021 398 µM 2.55116873579486 0.00987733790317766 no 92 0.00536811663269517 102 3098024 SGTC_1227 3909-8010 46.6 µM 2.54580122367977 0.0100075985458077 no 93 0.00545136262637507 114 15982272 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 2.54244002996976 0.0100899304545632 no 94 0.00550407449396678 99 6857784 SGTC_571 k831-0106 44.2 µM 2.53601669910368 0.0102489141066726 no 95 0.00560606936999855 100 4783639 SGTC_1781 st038725 66.3 µM 2.52744157883567 0.0104645590967553 no 96 0.00574484689646658 228 4270275 YIL048W NEO1 SGTC_1963 st076565 50.3 µM 2.52022491103642 0.0106490956556344 no 97 0.00586399348801031 90 4914280 SGTC_1241 0364-0022 50.8 µM 2.50857243587861 0.0109530441244431 no 98 0.00606100558414713 128 4563895 SGTC_161 4065-0411 162.148 µM 2.5078849261526 0.0109712109313879 no 99 0.00607281068825223 186 1906281 YLR208W SEC13 SGTC_137 0438-0332 85.389 µM 2.50039735068503 0.0111707668268966 no 100 0.0062027039019815 254 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1428 4049-0204 61.7 µM 2.49703176575987 0.01126148834528 no 101 0.00626188686851486 95 X1428 SGTC_486 niguldipine 82 µM 2.49159863217673 0.0114092935159629 no 102 0.00635848264966145 79 1236 A calcium channel blocker. SGTC_2242 6630449 61.2675 µM 2.48923468149432 0.011474127775987 no 103 0.00640092151730975 131 691249 YDR170C SEC7 SGTC_401 neomycin 50 µM 2.45621451487966 0.0124137554813168 no 104 0.00702046574080527 85 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_53 0973-0023 39.979 µM 2.44324862631308 0.0128005416668802 no 105 0.00727785288415066 114 674768 SGTC_921 1561-0023 372 µM 2.4375362364604 0.0129742297702357 no 106 0.00739386601110749 129 24050882 SGTC_1736 st036774 51 µM 2.43427326460058 0.0130743535802932 no 107 0.00746086257622523 131 1272247 SGTC_634 1611-4317 11.2 µM 2.43365951073074 0.0130932609673914 no 108 0.0074735239932567 124 2843522 SGTC_286 k060-0067 22.9 µM 2.43243040576198 0.013131196006688 no 109 0.00749893670237473 110 5985051 SGTC_1818 st052136 56.3 µM 2.4298831775943 0.0132101160342754 no 110 0.00755184510549311 174 674169 SGTC_295 k015-0027 31 µM 2.42481570374901 0.0133683393647132 no 111 0.00765807990823828 104 3887424 SGTC_878 0828-0289 13.7 µM 2.415468052981 0.0136645008002256 no 112 0.00785750050192208 183 745350 YLR208W SEC13 SGTC_1357 1503-1303 39.5 µM 2.41439574724986 0.0136988339085678 no 113 0.00788066637378241 159 292895 SGTC_2939 9044578 71.43 µM 2.41388975151291 0.013715060720137 no 114 0.00789161864832357 160 2653634 SGTC_1469 k284-2957 126 µM 2.40932443137499 0.0138622175382917 no 115 0.00799104181847238 100 23884841 SGTC_2990 9074105 71.4286 µM 2.40496858885556 0.0140038894208647 no 116 0.00808692795668486 99 6502001 SGTC_2371 9071574 200 µM 2.40226538205809 0.0140924362177043 no 117 0.00814694146437058 94 45596039 SGTC_1229 0139-0193 12.2 µM 2.39338456941547 0.0143867424557582 no 118 0.00834686662770153 122 3090752 SGTC_1387 3342-1166 1.8 µM 2.39042256994526 0.0144860716560092 no 119 0.00841449865620784 82 3418228 SGTC_2580 diallyl disulphide 81.36 µM 2.38445072335292 0.0146881306195504 no 120 0.00855231928525405 131 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_560 2332-1943 155 µM 2.36312121378477 0.0154297373774218 no 121 0.00906087065298337 93 21177716 SGTC_3098 9119039 49.47 µM 2.35841450146272 0.0155976471789679 no 122 0.00917659351033893 146 17161528 SGTC_1386 3228-0095 33.8 µM 2.35768437308166 0.0156238341520482 no 123 0.00919466044362021 116 870181 SGTC_2432 5630864 12.22 µM 2.35060228077207 0.0158798059062814 no 124 0.00937152783028592 162 5714970 SGTC_755 1995-0008 37.3 µM 2.34422146488373 0.0161135022151875 no 125 0.00953342301507224 131 689533 SGTC_2009 4012297 12.05 µM 2.33874589182739 0.0163163877355272 no 126 0.0096742942683049 176 45595307 SGTC_670 4204-0025 119 µM 2.32677803191606 0.0167674590837202 no 127 0.00998854110588922 160 719039 SGTC_1261 0712-0010 12.7 µM 2.32173773533011 0.0169605973721403 no 128 0.0101235308731577 160 2840123 SGTC_3109 9122853 49.47 µM 2.31936624906779 0.0170521259698344 no 129 0.0101875930338338 108 1234709 SGTC_2469 5655019 90.81 µM 2.3180429826857 0.0171033813180682 no 130 0.0102234925827033 154 2788239 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 2.29898611439636 0.0178562555167051 no 131 0.0107528639056034 184 442882 SGTC_1035 k081-0041 55.2 µM 2.28495416736291 0.0184285209409608 no 132 0.011157757675159 158 731709 SGTC_2388 9080168 200 µM 2.28335290516244 0.0184948075341399 no 133 0.0112047944952532 99 15943073 SGTC_1427 4048-4900 550 nM 2.27574978096013 0.018812327472985 no 134 0.0114304950027809 143 24132586 SGTC_1037 k284-1091 78.7 µM 2.26607425711279 0.0192230910897148 no 135 0.0117234185498919 131 3334711 SGTC_2776 terbinafine 19.92 µM 2.26069745759018 0.0194546349033048 no 136 0.0118889990124737 181 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2488 5268135 45.7 µM 2.26036985752897 0.0194688187578223 no 137 0.0118991528205546 210 1270356 YLR208W SEC13 SGTC_612 0302-0167 22.4 µM 2.25915325062553 0.0195215701861883 no 138 0.0119369268424779 196 235821 SGTC_1231 0242-0792 125 µM 2.2555722514676 0.0196775454723717 no 139 0.0120487163264384 147 3707635 SGTC_1581 himbacine 57.9 µM 2.24980397548064 0.0199310150754612 no 140 0.0122306957772697 192 5281825 An alkaloid muscarinic receptor antagonist. SGTC_547 1120-0019 610 nM 2.24642347511299 0.0200808445571342 no 141 0.0123384480424693 177 3676939 SGTC_2517 totarol 10 µM 2.23977447443683 0.020378328011429 no 142 0.0125527839049912 149 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_710 3448-4187 58 µM 2.23271969735909 0.0206980419658691 no 143 0.0127837173413772 259 3946412 SGTC_182 3448-4371 550.524 µM 2.21380163374399 0.0215764222432812 no 144 0.0134212138243142 161 3491403 SGTC_2704 st078022 71.1 µM 2.19853504074531 0.0223080418441223 no 145 0.0139555001634475 156 54697681 SGTC_2397 5161689 200 µM 2.19304430371985 0.022576241210221 no 146 0.0141520936150859 194 2259942 SGTC_23 0213-0011 39.996 µM 2.19001655568393 0.0227252932711864 no 147 0.0142615180815116 169 627608 SGTC_1299 1079-1439 3.74 µM 2.1841446527697 0.0230167238476211 no 148 0.0144758102064178 148 323161 SGTC_1378 2093-0007 380 nM 2.18203107626865 0.0231223910655294 no 149 0.0145536196394768 187 3618014 SGTC_1722 st034304 3.6505 µM 2.16500774659883 0.0239884481532131 no 150 0.0151935460166468 205 4036148 YLR033W RSC58 SGTC_2019 4016004 108 µM 2.15649975202875 0.024431406663248 no 151 0.0155223315578649 181 45595336 SGTC_3241 9133421 49.47 µM 2.14832994908453 0.0248631999615303 no 152 0.0158437766664456 69 17018221 SGTC_474 dl-dihydrosphingosine 5 µM 2.13852839874663 0.0253896620877586 no 153 0.0162369408885224 199 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2735 sertaconazole 140 nM 2.12149723152999 0.0263266456795041 no 154 0.0169399903356853 108 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_640 3381-0960 37.1 µM 2.12027859196329 0.0263947840060579 no 155 0.016991278977597 166 1745025 SGTC_913 3487-1245 167 µM 2.11723176133369 0.0265657879326374 no 156 0.0171200915291134 219 4016153 SGTC_3208 9114115 49.47 µM 2.10690342558983 0.0271523687630335 no 157 0.0175629758147527 219 650895 SGTC_1167 k781-0610 148 µM 2.09965030650393 0.0275707249278538 no 158 0.0178798069888195 222 4525169 SGTC_2992 9074591 71.4286 µM 2.08830351916889 0.0282359712027041 no 159 0.018385232108942 152 17741321 SGTC_3220 9131269 49.47 µM 2.08382233213223 0.0285023518579086 no 160 0.0185881655929013 136 17722206 SGTC_3110 9122132 49.47 µM 2.0775800423583 0.0288769014817284 no 161 0.0188740279716804 170 918317 SGTC_2724 maprotiline 69.64 µM 2.07546738826556 0.0290045878827773 no 162 0.0189716191411398 165 4011 A tricyclic antidepressant. SGTC_1193 1488-0126 41.5 µM 2.07523162065631 0.0290188664652209 no 163 0.0189825366771517 210 1384710 SGTC_1796 st049173 110.4 µM 2.05955276972206 0.0299816044211718 no 164 0.0197206576762957 141 94134 SGTC_2449 5812982 45.77 µM 2.05556634368805 0.0302305648285867 no 165 0.0199121673496311 148 776185 SGTC_322 k048-0136 19.3 µM 2.05419337800767 0.0303167050333989 no 166 0.0199784895380409 168 6823282 SGTC_3280 9140961 49.47 µM 2.04266666957775 0.0310479452556933 no 167 0.0205427232071966 173 4901226 SGTC_1395 3486-0190 4.35 µM 2.04240731709228 0.0310645646738009 no 168 0.0205555722700031 198 6748079 SGTC_1943 st076331 65.2 µM 2.0399872991155 0.0312199955101117 no 169 0.0206757953794264 189 24208415 SGTC_1539 benzyladenosine 56 µM 2.03753871886667 0.0313779149410622 no 170 0.0207980429917697 183 92208 A nucleotide analog. SGTC_600 1495-0418 41.6 µM 2.02775934370038 0.0320152292032311 no 171 0.0212924078261493 196 5377768 SGTC_350 k064-0020 19.8 µM 2.02734403989811 0.032042529114191 no 172 0.0213136202886712 244 2790705 SGTC_510 ag-490 170 µM 2.02123923243521 0.0324460500760043 no 173 0.0216275031337617 140 5328779 SGTC_2097 5376186 200 µM 2.01948066307371 0.0325630642847741 no 174 0.0217186425699281 234 742755 SGTC_2267 7931562 200 µM 1.99525823889612 0.0342105203019175 no 175 0.0230073610425498 197 934880 SGTC_775 4577-0580 57.3 µM 1.98679845367275 0.0348018034292592 no 176 0.0234723680303862 195 2006902 SGTC_855 0428-0020 25 µM 1.98450856308857 0.0349632867779516 no 177 0.0235995872195401 188 6812414 SGTC_168 3970-0862 530.542 µM 1.9841502310216 0.0349886119585793 no 178 0.0236195474141798 451 3135186 SGTC_1404 3909-7820 48.3 µM 1.97641997714291 0.035538624638044 no 179 0.0240536154032156 195 23741373 SGTC_1604 st002052 72.4 µM 1.97333693579281 0.0357599532432949 no 180 0.0242285937085232 220 6254834 YHR062C RPP1 SGTC_1113 artemisinin 1.17947 µM 1.97078129092236 0.0359442756597666 no 181 0.0243744487914373 205 2240 An anti-malaria and mitochondrial poison. SGTC_1244 0416-0015 52.5 µM 1.96867074188809 0.0360970822507618 no 182 0.0244954566039674 246 96201 SGTC_746 1095-0025 46.6 µM 1.96251234340856 0.0365460017065141 no 183 0.0248514324823707 226 6749286 SGTC_2575 plumbagin 510 nM 1.96077314953105 0.0366736050105875 no 184 0.024952745781722 249 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2459 5811157 9.22 µM 1.96018887223461 0.0367165546751548 no 185 0.0249868593193375 210 2870684 YBR192W RIM2 SGTC_944 3370-0224 231 µM 1.95926660094598 0.0367844336689283 no 186 0.0250407864976273 237 4580514 SGTC_1827 berberine 7.24 µM 1.9575133083367 0.0369137586587941 no 187 0.0251435743329802 220 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2689 tacrolimus 100 µM 1.95420521922532 0.0371587796286518 no 188 0.025338476167516 258 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1250 0485-0349 40.2 µM 1.93623703060595 0.038512946364648 no 189 0.0264193385216555 253 6842794 YDL195W SEC31 SGTC_391 gliotoxin 8.33 µM 1.93431839389468 0.0386598906482539 no 190 0.0265369965253678 279 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2332 7982454 138.89 µM 1.92665788467631 0.0392511520230363 no 191 0.0270111398479448 305 2981748 SGTC_2246 7293507 91.5585 µM 1.92486724907449 0.0393904145914423 no 192 0.0271229840687322 256 887656 SGTC_971 1315-0384 26.7 µM 1.92432308005508 0.039432815643866 no 193 0.0271570496702656 251 6769120 SGTC_2956 9076196 2.52 µM 1.91960824104953 0.0398017473243463 no 194 0.0274537011589998 246 16423868 SGTC_1973 st070275 50.2 µM 1.90473463625723 0.0409840165175253 no 195 0.0284072871230648 220 17118334 SGTC_1133 3473-0247 50 µM 1.90011358174766 0.0413570799003093 no 196 0.028709107861216 303 711311 SGTC_2885 9057732 51.95 µM 1.89784228473946 0.0415414507767442 no 197 0.028858430563039 246 6471414 SGTC_1727 st034309 9.9045 µM 1.89457136529338 0.041808134758917 no 198 0.0290746056923027 337 870305 SGTC_1074 carmofur 3.8 µM 1.89216743286105 0.0420050142573063 no 199 0.0292343380160107 312 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1983 st071813 46.9 µM 1.88749175974923 0.0423900961385948 no 200 0.0295471068193494 239 11838595 SGTC_2120 5538279 151.968 µM 1.88666796155677 0.0424582379711098 no 201 0.0296024997470531 250 2058197 SGTC_1451 4152-0210 104 µM 1.88637682724319 0.0424823408047226 no 202 0.029622096479156 280 659563 SGTC_2865 9030313 51.95 µM 1.88276414334703 0.0427823543253768 no 203 0.0298661691797098 208 42562754 SGTC_1908 st060353 56.5 µM 1.87734473043672 0.0432356157805946 no 204 0.0302354306538516 309 4227716 SGTC_412 gemfibrozil 100 µM 1.87666915728581 0.04329238930066 no 205 0.0302817261844077 197 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1005 4092-0690 4.4 µM 1.87540027990313 0.0433991853710055 no 206 0.0303688383319738 259 1529343 SGTC_3353 9151644 39.2805 µM 1.87216660620916 0.0436723119704753 no 207 0.0305917787387531 247 4909158 SGTC_314 1671-0008 2.74 µM 1.86619233832633 0.0441805654462845 no 208 0.0310072303153278 323 3913060 SGTC_2963 9082507 9 µM 1.86040717835878 0.044677264578594 no 209 0.0314139699288513 246 16459611 SGTC_2832 7992762 51.95 µM 1.85955465249884 0.044750839026328 no 210 0.0314742800889067 253 2985177 SGTC_1625 st003711 30.1 µM 1.8587389917635 0.0448213232507732 no 211 0.0315320718708566 270 24207034 YER133W GLC7 SGTC_3184 9108758 49.47 µM 1.85708322322301 0.0449646791473114 no 212 0.0316496573392961 208 902885 SGTC_1044 1222-0021 1.78 µM 1.85468973900726 0.0451725583412928 no 213 0.0318202724404493 290 4306703 SGTC_536 3852-0578 10.6 µM 1.85055979542109 0.0455330704823832 no 214 0.0321164540931427 248 2869208 SGTC_1502 4534-4282 27.7 µM 1.84973044830332 0.0456057442648738 no 215 0.0321762048487224 213 3278949 SGTC_3146 9095609 49.47 µM 1.84753551732964 0.0457985310845951 no 216 0.0323347827363862 252 17173999 SGTC_1181 1222-0449 220 µM 1.84652271898373 0.0458877085113925 no 217 0.0324081718571684 256 658318 SGTC_2721 ifenprodil 61.44 µM 1.84222043759919 0.0462680830139047 no 218 0.0327214560601155 263 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_198 3454-2873 16.191 µM 1.82485475137635 0.0478292264014521 no 219 0.0340114755043926 264 710957 SGTC_1425 4048-4433 7.33 µM 1.82471174024904 0.0478422557842834 no 220 0.0340222703305758 293 23734946 SGTC_1574 spiramycin 23.7 µM 1.81950742336378 0.0483183443786487 no 221 0.0344170256590711 300 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.81825545477282 0.0484334375513488 no 222 0.0345125488673992 359 688664 SGTC_2733 amorolfine 100 µM 1.8155566323679 0.0486822853602199 no 223 0.0347192056144555 138 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3229 9132204 49.47 µM 1.79611613155533 0.0505051456097325 no 224 0.0362380246951909 187 17682924 SGTC_3289 9119912 71.43 µM 1.79248056130439 0.0508519991812534 no 225 0.0365280101212156 286 17014829 SGTC_2588 indole-3-carbinol 100 µM 1.79138463349502 0.0509569279825471 no 226 0.0366157965534735 350 3712 Induces cell cycle arrest. SGTC_2178 5812956 200 µM 1.78445392131003 0.051624500889937 no 227 0.0371749679547032 255 5403383 SGTC_1156 4092-0367 4.88 µM 1.78434978517298 0.0516345841519434 no 228 0.0371834225958106 318 1357585 SGTC_1355 1499-0035 1.68 µM 1.77995102133536 0.0520619381039634 no 229 0.0375419883384239 291 1548538 SGTC_2537 larixol 68.93 µM 1.77786728414533 0.0522653582472969 no 230 0.0377128272812784 312 6708759 SGTC_2937 9044753 11.33 µM 1.77407474901003 0.0526372153029242 no 231 0.0380253934565023 348 6465530 YGL099W LSG1 SGTC_3333 9141820 12.094 µM 1.76422543532331 0.0536127481817809 no 232 0.038847016008238 246 1939433 SGTC_1114 scopoletin 1.73284 µM 1.76068565662415 0.0539668268474004 no 233 0.0391458108770563 260 5280460 A coumarin with genotoxic properties. SGTC_299 1273-0059 1.44 µM 1.758986500783 0.054137447150434 no 234 0.0392899007251054 270 2848077 SGTC_824 1304-0008 100 µM 1.75382508869461 0.0546583480276156 no 235 0.0397302413631631 349 768245 SGTC_2883 9059145 45.46 µM 1.75326218496583 0.0547153963411279 no 236 0.0397785066434602 252 16476510 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.75148072090302 0.0548962517326075 no 237 0.0399315696583315 321 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1819 st053448 58.6 µM 1.74959409188511 0.0550882983102183 no 238 0.0400941899679184 289 2857616 SGTC_1443 4112-3303 14 µM 1.74937403188949 0.055110733512892 no 239 0.0401131933020828 313 704433 SGTC_1680 diphenhydramine 100 µM 1.74379694519757 0.0556817329109797 no 240 0.0405972516779422 322 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2070 5230947 200 µM 1.74257993931625 0.0558069521828882 no 241 0.0407035083440436 297 2835538 SGTC_806 3966-4455 5.86 µM 1.74195973278517 0.0558708514279568 no 242 0.0407577452688419 274 714982 SGTC_2830 7992007 71.43 µM 1.74027044056201 0.0560451902278255 no 243 0.040905770946019 288 1952075 SGTC_2734 clemastine 41.6 µM 1.73941712446876 0.0561334173432249 no 244 0.0409807091164957 144 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3031 9088762 49.47 µM 1.7333299001609 0.0567659763223535 no 245 0.0415185246187785 319 205253 SGTC_3300 9124615 50.48 µM 1.73243061514144 0.056859900426726 no 246 0.041598460478961 326 24824903 SGTC_832 4083-0019 164 µM 1.7268647528695 0.0574439418068686 no 247 0.0420959779528995 513 1990758 SGTC_990 3985-0011 41.3 µM 1.72609525345966 0.0575250575382859 no 248 0.0421651388132917 273 5399565 YGL099W LSG1 SGTC_835 0312-0010 67.2 µM 1.72436890783011 0.0577073657031371 no 249 0.0423206334043223 275 1626196 SGTC_2649 anisomycin 9.56 µM 1.72388850785378 0.0577581783487098 no 250 0.0423639861754675 243 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2117 5521686 200 µM 1.72088909958746 0.0580762262915058 no 251 0.0426354749824747 312 803312 SGTC_2217 6934799 96.0675 µM 1.72020774943236 0.0581486660154393 no 252 0.0426973424462562 272 675606 SGTC_116 0155-0182 31.788 µM 1.71951755552664 0.0582221183505937 no 253 0.0427600869079879 472 771486 SGTC_958 1222-0007 33 µM 1.71485787396869 0.0587199233532749 no 254 0.0431856438639215 342 7312461 SGTC_2880 9042983 58.44 µM 1.71376298853429 0.0588373759387595 no 255 0.0432861316759653 315 6464714 SGTC_2630 antimycin a 100 µM 1.7124879274322 0.058974388938279 no 256 0.0434033937712535 365 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2622 2-methoxyxanthone 59.94 µM 1.71076078444069 0.059160379888979 no 257 0.0435626407959527 308 71034 A hepatoprotective. SGTC_95 0471-0001 561.058 µM 1.70755472280426 0.0595068504939625 no 258 0.0438594978533031 337 4015405 SGTC_1616 st002734 56.1 µM 1.70591986432382 0.0596841365530464 no 259 0.0440115003746456 365 4026101 SGTC_1476 4112-3294 3.34 µM 1.70521114160838 0.059761119790233 no 260 0.0440775264022451 303 704369 SGTC_2862 9027634 71.43 µM 1.70451401715444 0.0598369190677242 no 261 0.0441425498051332 312 5012562 SGTC_472 calcifediol 10 µM 1.7026403812102 0.0600410152514574 no 262 0.0443176941191283 245 5283731 A vitamin D metabolite. SGTC_3135 9127742 49.47 µM 1.70203109500031 0.0601075024581729 no 263 0.0443747696867656 284 3643468 SGTC_1218 1348-1416 30.7 µM 1.69499744077038 0.0608792169706765 no 264 0.0450379531363197 309 6787668 SGTC_31 0508-1974 57.237 µM 1.68799417902919 0.0616552721084908 no 265 0.0457061731728299 315 6810525 SGTC_1088 bifonazole 369 nM 1.68796691582276 0.06165830825969 no 266 0.0457087899941538 298 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1997 st073024 93.8 µM 1.68449461784724 0.0620459538501704 no 267 0.046043059371821 303 686268 SGTC_1413 3910-0535 34.4 µM 1.67590226609738 0.0630133745773064 no 268 0.046878668896139 327 2876951 SGTC_2600 tangeritin 87.95 µM 1.67194855056935 0.0634624556489031 no 269 0.0472672339326527 316 68077 A bioactive flavone. SGTC_2369 9071472 200 µM 1.67045362069484 0.0636329041532499 no 270 0.0474148241567367 355 17296037 SGTC_883 0850-0245 24.6 µM 1.6658611164061 0.0641587594742423 no 271 0.0478705399164895 373 6823229 YPR165W RHO1 SGTC_1613 st002381 52.1 µM 1.66330581491301 0.0644528082716869 no 272 0.0481256176633629 341 551167 SGTC_1431 4049-0260 9.09 µM 1.66194247666344 0.0646101208522595 no 273 0.048262154390917 332 3854841 SGTC_603 3794-0023 45.9 µM 1.65648171746422 0.0652432169434952 no 274 0.0488121522358381 296 3802260 SGTC_2282 7944268 200 µM 1.64855324525322 0.066170962436697 no 275 0.0496195969793648 385 2970414 SGTC_3019 9081971 49.47 µM 1.63692146549291 0.0675504996896713 no 276 0.0508234400755908 332 16451803 SGTC_1661 st013063 9.66 µM 1.62861621740957 0.068549031661599 no 277 0.0516971444753789 388 721395 SGTC_2378 9074213 121.43 µM 1.62304447152037 0.0692252727307884 no 278 0.0522899492728617 385 657714 SGTC_1491 4138-0063 26.5 µM 1.62018280633533 0.0695745841070791 no 279 0.0525965068504343 306 23883227 SGTC_2301 7769476 200 µM 1.61183834101363 0.0706009076948809 no 280 0.0534985612402242 323 977820 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.61040249045675 0.0707786769236591 no 281 0.0536550086293961 350 1609 A potent and irreversible inhibitor of serine proteases. SGTC_473 2-arachidonoylglycerol 10 µM 1.61003334558132 0.0708244353983418 no 282 0.0536952884167005 352 5282280 An endocannabinoid. SGTC_1414 3917-0015 5.4 µM 1.60998495375898 0.0708304356383641 no 283 0.0537005705369283 316 6618702 SGTC_1341 1486-1360 280 µM 1.60991824523005 0.0708387076593115 no 284 0.0537078526582166 384 3976547 SGTC_573 3702-0553 84.7 µM 1.608510878034 0.0710133976909683 no 285 0.0538616678527606 353 1222756 SGTC_1189 1431-2119 7.28 µM 1.60584860217193 0.0713447584514777 no 286 0.0541535894311424 415 3107275 SGTC_887 0885-0007 9.62 µM 1.60473798652314 0.0714833417928839 no 287 0.0542757392172336 403 5719458 SGTC_3005 9076496 71.4286 µM 1.59620200465804 0.0725553715161991 no 288 0.0552218500981887 318 21368410 SGTC_1681 tripelennamine 100 µM 1.59583216056114 0.0726020968868406 no 289 0.0552631354503876 321 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_808 0711-0032 135 µM 1.59528496056503 0.0726712713203628 no 290 0.0553242635884663 349 4252555 SGTC_2281 7943571 200 µM 1.59178676080718 0.0731146904783656 no 291 0.0557163129453591 371 1244024 SGTC_2145 5634607 200 µM 1.58880929181812 0.0734937321919533 no 292 0.0560517274222234 316 308662 SGTC_745 0469-0705 296 µM 1.58861352978872 0.0735187058987155 no 293 0.0560738358588108 423 3486736 SGTC_1179 1021-1431 9.29 µM 1.58370511018228 0.0741470049428097 no 294 0.0566304206871159 468 2840958 SGTC_682 0kpi-0099 17 µM 1.58280252135309 0.0742629853692748 no 295 0.0567332409359193 441 1714895 YML126C ERG13 SGTC_2792 7535235 81.82 µM 1.58004906630946 0.0746176535533248 no 296 0.0570478151275661 363 1281891 SGTC_2777 climbazole 1.536 µM 1.57899304748709 0.074754020125102 no 297 0.0571688258842653 411 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1157 4092-0394 27.6 µM 1.57781198513239 0.0749067590829956 no 298 0.057304404805426 428 3659885 SGTC_2805 7950783 58.44 µM 1.57713044242013 0.0749950067404025 no 299 0.0573827569001191 447 1178958 YDL195W SEC31 SGTC_2292 7671323 168.05 µM 1.57486095091702 0.0752894372168433 no 300 0.0576442719006341 403 937504 SGTC_1547 harmine 94.2 µM 1.57414871423627 0.075382020047209 no 301 0.0577265363489077 461 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_531 3788-1495 174 µM 1.57010193591431 0.0759097040655431 no 302 0.0581956991441158 388 2896655 SGTC_549 1661-1316 519 µM 1.56713707868483 0.0762980917550496 no 303 0.0585413269811772 385 2857282 SGTC_2683 piperine 63.03 µM 1.56587356241089 0.0764640675239859 no 304 0.0586891101184749 332 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_723 4182-0001 115 µM 1.56513117683233 0.0765617154779647 no 305 0.0587760773519783 369 744821 YLR208W SEC13 SGTC_1660 st012960 28.1 µM 1.56160991412483 0.0770261688643639 no 306 0.0591899562481211 411 24207266 SGTC_3211 9128781 49.47 µM 1.56047196401163 0.0771767210324257 no 307 0.0593241951300875 422 17194361 SGTC_3057 9095946 49.47 µM 1.55528273229646 0.0778660983563575 no 308 0.0599393740088982 362 24540043 SGTC_1362 1611-0397 101 µM 1.55437735300559 0.077986853210103 no 309 0.0600472160146452 379 27816 SGTC_2356 9061756 188.97 µM 1.54980598532792 0.0785987296181098 no 310 0.0605940450101206 344 20104043 SGTC_1213 1315-0166 115 µM 1.54823353199293 0.0788100410376317 no 311 0.0607830404367559 346 768401 SGTC_550 4123-0385 25.7 µM 1.54820876326483 0.0788133729803046 no 312 0.0607860211094151 380 5731123 SGTC_57 miconazole 162.5 nM 1.54536012150528 0.0791972908390075 no 313 0.0611295902816286 366 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2623 humulene 100 µM 1.53502289314304 0.0806023595969615 no 314 0.0623891023766252 340 6187145 An anti-inflammatory. SGTC_2645 abamectin 100 µM 1.53435983384704 0.080693123218389 no 315 0.0624705766350751 404 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1950 st077106 7.18 µM 1.53127917387745 0.0811158354484372 no 316 0.0628502051998572 415 13831864 SGTC_1354 1498-1681 81 µM 1.52870394749499 0.0814704752032771 no 317 0.0631689266340313 429 5754243 SGTC_681 1642-0006 26.6 µM 1.52870328810231 0.0814705661591099 no 318 0.0631690084042677 337 4446530 SGTC_856 0433-0016 11.3 µM 1.52533856570456 0.0819356898340173 no 319 0.0635873366416015 423 3911780 SGTC_2131 toluylene red 5.2905 µM 1.52176302209977 0.0824321464855701 no 320 0.0640342349901748 425 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1171 0368-0077 21.4 µM 1.52173006658588 0.0824367327989372 no 321 0.0640383653469202 372 3239779 SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.52038753017663 0.082623732664467 no 322 0.0642068033213719 399 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2572 astragaloside iv 100 µM 1.51988187000935 0.082694248015574 no 323 0.0642703339140945 413 45006101 An anti-inflammatory agent. SGTC_1953 st076800 12.1 µM 1.51794088948538 0.0829653423590376 no 324 0.0645146503689991 451 297591 SGTC_2581 avocatin a 64 µM 1.51786091248205 0.0829765269710631 no 325 0.0645247327458099 464 6710728 A skin care supplement. SGTC_680 0417-1641 114 µM 1.51776076785898 0.0829905335805359 no 326 0.064537359298664 376 2835990 SGTC_3344 9148862 3.898 µM 1.51701900019281 0.083094335414927 no 327 0.0646309434964678 388 4905352 SGTC_1347 1493-0251 600 nM 1.5156364530803 0.0832880674880025 no 328 0.0648056521052725 431 3986378 SGTC_3097 9117246 49.47 µM 1.51450264657643 0.0834471975693446 no 329 0.0649492015450588 414 16423892 SGTC_406 estrone 100 µM 1.51036594347173 0.0840297230735459 no 330 0.0654750368390601 418 5870 A steroid. SGTC_525 k781-2675 26.7 µM 1.50856045763682 0.0842849243860846 no 331 0.0657055728451093 450 3651118 YDL195W SEC31 SGTC_2674 ligustilide 100 µM 1.50405532420208 0.0849242506897541 no 332 0.0662835611285834 374 5319022 A signalling regulator. SGTC_1467 k284-1082 293 µM 1.5029520340088 0.0850813720395346 no 333 0.0664257067383884 422 3334705 SGTC_3279 9140807 49.47 µM 1.49956371761783 0.0855652695989764 no 334 0.0668637260057786 394 45595718 SGTC_1677 st019204 53.9 µM 1.49481973137238 0.0862462338323218 no 335 0.0674807476742846 407 3945625 SGTC_1627 st003713 25.6 µM 1.494807261365 0.0862480291356702 no 336 0.0674823753517388 532 16195070 YER133W GLC7 SGTC_895 0964-0006 13.7 µM 1.49436185111985 0.0863121730503125 no 337 0.0675405334849831 410 6738897 SGTC_2300 7976697 71.57 µM 1.49336952435888 0.0864552071549224 no 338 0.0676702428922958 356 2236109 SGTC_1886 st057356 49.9 µM 1.49030654166564 0.0868978235865824 no 339 0.0680718266180635 400 24207747 SGTC_787 4152-0075 138 µM 1.48450904366029 0.0877402222997315 no 340 0.0688369628652904 426 9566539 SGTC_1992 st073643 23.3 µM 1.48079417531854 0.0882832002797816 no 341 0.069330714573133 409 3161292 SGTC_652 0437-0092 114 µM 1.47656988990759 0.0889036749263582 no 342 0.0698954839493799 381 3091274 SGTC_2759 disulfiram 3.38 µM 1.47372036892482 0.0893240503002998 no 343 0.0702784481336586 434 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_914 3820-6779 408 µM 1.47349726051117 0.089357026670711 no 344 0.0703085009931129 417 2893481 SGTC_521 r062-0005 13.8 µM 1.46942107812369 0.0899610988979092 no 345 0.0708593068333564 416 2832033 SGTC_2722 naftopidil 47.16 µM 1.4690794899794 0.090011858229404 no 346 0.0709056150323146 437 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1264 0783-0040 158 µM 1.46463253790637 0.0906746096992276 no 347 0.0715105998397257 412 2855798 SGTC_3101 9120531 49.47 µM 1.46426390909799 0.0907297104217643 no 348 0.0715609271245569 464 24824904 SGTC_2247 cerulenin 830 nM 1.46412263194696 0.0907508343829419 no 349 0.0715802222804083 455 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1571 st070080 73.4 µM 1.46368784699819 0.0908158669485955 no 350 0.0716396287858102 433 4315245 SGTC_3343 9148379 18.9835 µM 1.45911192957398 0.0915024039479372 no 351 0.0722671516632317 424 1955036 SGTC_2101 5377231 179.231 µM 1.45826917422674 0.0916292631083407 no 352 0.0723831817047472 408 2844213 SGTC_1026 k007-1105 30.6 µM 1.45530194286334 0.0920769548171911 no 353 0.0727928445090727 539 7066794 SGTC_1644 st010134 20.9 µM 1.45390191938003 0.0922887498696539 no 354 0.0729867503059784 416 3818134 SGTC_1934 st074720 32.6 µM 1.44707709993696 0.0933263709013912 no 355 0.073937665482789 519 17250992 SGTC_119 0121-0043 24.815 µM 1.44346139981492 0.0938795694308448 no 356 0.0744452692943473 640 1092378 SGTC_340 k038-0059 454 µM 1.43721853173174 0.0948404126919819 no 357 0.0753279544613541 471 23733424 SGTC_114 0364-0001 490.298 µM 1.43494155109726 0.0951926614358993 no 358 0.0756518769695011 464 4003655 SGTC_3023 9089636 49.47 µM 1.43410437190472 0.0953224149305288 no 359 0.0757712402441071 455 17249241 SGTC_726 3448-4391 34.2 µM 1.43392582033303 0.0953501052838369 no 360 0.0757967163068865 495 1356692 SGTC_2335 9018011 154.17 µM 1.43357216794182 0.0954049683160806 no 361 0.0758471953301056 515 6458208 SGTC_219 mitoxanthrone 164.414 µM 1.43067937530812 0.0958546075570057 no 362 0.0762610634384301 465 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_427 1354-0053 47.3 µM 1.43033065107057 0.0959089163708662 no 363 0.0763110708204677 465 6813657 SGTC_974 1326-0144 138 µM 1.42945483657536 0.0960454117386368 no 364 0.0764367734677661 491 5411856 SGTC_1049 3226-0134 66 µM 1.428978446039 0.0961197169801347 no 365 0.0765052142819409 503 5702385 SGTC_3003 9075612 71.4286 µM 1.42434593395045 0.0968444800264583 no 366 0.0771731784009763 465 6501993 SGTC_3138 9097216 49.47 µM 1.42149665212015 0.097292242660485 no 367 0.0775862130818403 443 25237486 SGTC_1780 st038448 24.544 µM 1.41794005131396 0.0978532889275611 no 368 0.0781041339368132 461 728868 YDL195W SEC31 SGTC_142 0335-0849 62.6745 µM 1.41692193736787 0.0980143299934638 no 369 0.0782528759456222 601 3889043 YPR107C YTH1 SGTC_2037 5169046 200 µM 1.41548376386515 0.0982421451538848 no 370 0.0784633527560875 436 5718022 SGTC_1364 1653-0028 37.6 µM 1.4153037096885 0.0982706940933216 no 371 0.078489733900815 485 5718652 SGTC_3274 9138298 49.47 µM 1.41419313515316 0.0984469183493974 no 372 0.0786526015216443 501 17015756 SGTC_252 miconazole 1.30953 nM 1.41346313471519 0.0985628796637297 no 373 0.0787597967381529 451 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_399 oxolinic acid 75 µM 1.41174079598321 0.0988368711438327 no 374 0.0790131482267821 442 4628 A DNA gyrase inhibitor. SGTC_480 am 92016 50 µM 1.40916503351955 0.0992476655165349 no 375 0.0793931872345961 418 2129 K+ channel blocker. SGTC_1509 1326-1131 80 µM 1.4083824404959 0.0993727239629334 no 376 0.0795089279603056 421 768313 SGTC_2072 5231554 129 µM 1.4050694709676 0.0999034129722816 no 377 0.0800003106150519 471 789545 SGTC_3278 9139605 49.47 µM 1.40390491090601 0.100090449186747 no 378 0.0801735835573082 466 7958859 SGTC_2785 7756463 72.73 µM 1.40236289195364 0.100338501062379 no 379 0.080403454270641 472 2201551 SGTC_1929 genistein trimethyl ether 50.5 µM 1.40216266275535 0.100370743163874 no 380 0.0804333391821686 471 136420 SGTC_2265 7929201 200 µM 1.40204911946469 0.100389029941731 no 381 0.0804502896457278 484 1265108 SGTC_2436 5633522 8.09 µM 1.39575638212343 0.101406314879428 no 382 0.0813939346465746 510 5724242 SGTC_2655 perillic acid 100 µM 1.39238572040241 0.10195429516447 no 383 0.0819028131166326 426 5702197 An apoptosis inducer. SGTC_805 3852-0218 479 µM 1.39233118864544 0.101963178262603 no 384 0.0819110655958201 487 6615355 SGTC_2628 lathosterol 100 µM 1.38804445474213 0.102663240853126 no 385 0.0825617543899816 495 6710616 SGTC_1695 st026914 34.495 µM 1.38650069430854 0.102916204615706 no 386 0.0827970342077081 491 3289191 SGTC_1847 st056231 15 µM 1.38597485802616 0.103002472540187 no 387 0.0828772903906814 561 5393180 SGTC_1507 4075-3230 155 µM 1.38458562795531 0.103230640258612 no 388 0.0830896042889264 410 659771 SGTC_620 0109-0052 432 µM 1.38350927105234 0.103407673722736 no 389 0.0832543832951084 487 493037 SGTC_1649 st011737 51.3 µM 1.3784499739539 0.104242752764841 no 390 0.0840322015681105 489 1761035 SGTC_2699 st077704 54.6 µM 1.37425966975411 0.104938089452899 no 391 0.0846805410396135 493 645852 SGTC_1938 st074717 56.4 µM 1.37098383524432 0.105484013515303 no 392 0.0851899975808523 431 17250979 SGTC_1887 st057648 70.8 µM 1.36989393146431 0.105666102663432 no 393 0.0853600071695997 495 688672 SGTC_3227 9130768 49.47 µM 1.36972438011507 0.105694449854708 no 394 0.0853864776120831 459 17720899 SGTC_2173 5763948 167 µM 1.36932411639724 0.105761391521681 no 395 0.0854489913765395 527 2867177 SGTC_1559 coumarin 343 70.1 µM 1.36785301001057 0.106007688418592 no 396 0.0856790454212973 440 108770 A hepatotoxic, DNA x-linker. SGTC_197 4544-0043 41.561 µM 1.36183717986913 0.107019188825013 no 397 0.0866246375589996 544 896523 SGTC_3348 9149464 3.537 µM 1.35775178136609 0.107710064472641 no 398 0.0872712299501779 504 1951442 SGTC_988 1497-1057 103 µM 1.35611660382044 0.107987485385958 no 399 0.0875310353859816 503 3533044 SGTC_2161 5662504 8.5105 µM 1.35544747090669 0.108101157346902 no 400 0.0876375169360844 483 2859334 SGTC_720 r052-1644 49.9 µM 1.35404874684112 0.108339050066742 no 401 0.0878604131008018 443 1422863 YOR257W CDC31 SGTC_1012 4112-3522 18 µM 1.35206039515331 0.108677873771238 no 402 0.0881779977976569 499 3112398 SGTC_2450 5739737 12.93 µM 1.35109398239266 0.108842829614228 no 403 0.0883326644362068 485 2262825 SGTC_11 0438-0307 1.3 µM 1.34801934766945 0.109368832580269 no 404 0.0888260799164428 483 4011476 SGTC_1512 0259-0544 12.2 µM 1.34636753045447 0.109652175331217 no 405 0.0890920084977982 555 18476 SGTC_3149 9097855 49.47 µM 1.34197252508704 0.110408633639696 no 406 0.0898024521347838 499 25236625 YMR079W SEC14 SGTC_1707 st032323 6.317 µM 1.34130831591807 0.110523280491868 no 407 0.0899101854732818 552 3132057 YMR211W DML1 SGTC_565 1418-0001 44.5 µM 1.33990208886304 0.110766286029834 no 408 0.0901385894588415 557 2862145 SGTC_332 4112-0506 40.9 µM 1.33904087172184 0.110915299070306 no 409 0.0902786838246778 519 2790355 SGTC_2370 9071495 200 µM 1.33882724620632 0.110952284077721 no 410 0.0903134593490195 500 21791103 SGTC_3051 9093778 49.47 µM 1.33545299115594 0.11153764130229 no 411 0.0908640655446924 430 17217378 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.33091567091865 0.112328243022636 no 412 0.0916083801217051 571 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2896 9052656 71.43 µM 1.3276858265202 0.112893459135765 no 413 0.0921409588861661 644 6469436 SGTC_707 0865-0008 204 µM 1.32764156774372 0.112901218405665 no 414 0.0921482727354336 532 723043 SGTC_2475 5812728 15.03 µM 1.32610220875025 0.113171329525171 no 415 0.0924029223166373 547 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2732 terfenadine 20 µM 1.32566132877261 0.113248775546103 no 416 0.0924759510462044 449 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1816 st051957 91.6 µM 1.32146482097535 0.113987837203278 no 417 0.0931732124581393 505 674121 SGTC_1057 3448-5381 134 µM 1.31965517105055 0.114307599111231 no 418 0.093475086820035 546 5497911 SGTC_3147 9097027 49.47 µM 1.31871044355672 0.114474784299004 no 419 0.0936329669974265 558 25236841 SGTC_261 5-fluorouridine 15.376 µM 1.31848393779136 0.114514894104504 no 420 0.0936708492446548 537 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_385 1494-0393 12.4 µM 1.31665169502297 0.114839716755783 no 421 0.0939777011217984 540 3090647 SGTC_469 w7 172 µM 1.31646763437981 0.114872383485554 no 422 0.094008567332419 477 45115570 A P450 inhibitor. SGTC_1683 st010134 710 nM 1.31635342577703 0.114892656332092 no 423 0.0940277234045998 537 3818134 SGTC_3285 9112818 20.8695 µM 1.31481211404716 0.115166499178624 no 424 0.0942865275634859 577 17017947 YPR165W RHO1 SGTC_1124 fisetin 1.16336 µM 1.31300001126672 0.11548904622505 no 425 0.0945914721884185 488 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1294 1000-1494 117 µM 1.31298073545796 0.11549248068871 no 426 0.0945947198670828 521 712797 YDL207W GLE1 SGTC_2944 9067346 25.62 µM 1.31128272625968 0.115795307988486 no 427 0.0948811310548948 537 6473075 SGTC_490 phenamil 164 µM 1.3107569823675 0.115889184723505 no 428 0.0949699401567438 404 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2726 cimetidine 79.27 µM 1.30920226139847 0.116167111572824 no 429 0.0952329232119982 448 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_728 3030-5151 22.5 µM 1.30510959380151 0.116900990436824 no 430 0.0959277662062368 504 3125388 SGTC_2146 5545642 200 µM 1.30202588079142 0.117456114596507 no 431 0.0964537692470167 546 825326 SGTC_1211 1056-0033 32.3 µM 1.30111979421781 0.117619580805542 no 432 0.0966087266751841 555 6741922 SGTC_843 0310-0051 143 µM 1.29807642816356 0.118169810166579 no 433 0.097130536678813 549 2065037 SGTC_1840 st055363 71 µM 1.29804641577762 0.118175245343803 no 434 0.0971356928273868 478 676033 SGTC_1029 k015-0030 64.7 µM 1.29586128635816 0.118571442576003 no 435 0.0975116394955167 539 2208316 SGTC_1531 st059297 52.4 µM 1.29454389771533 0.118810758247674 no 436 0.097738808304689 565 7566702 SGTC_1174 0739-0097 51.1 µM 1.29432207114211 0.118851088607213 no 437 0.0977770979295239 572 728447 SGTC_178 4092-0806 87.505 µM 1.29365244230911 0.118972892685363 no 438 0.0978927496826439 640 2169044 SGTC_3113 9123498 49.47 µM 1.29147035900092 0.11937042060461 no 439 0.0982703134437542 534 8897275 SGTC_3020 9089140 49.47 µM 1.29135078519364 0.119392231396513 no 440 0.0982910339665647 540 17217859 SGTC_2824 7998404 51.95 µM 1.29005072576408 0.119629549494865 no 441 0.0985165232312388 513 837851 SGTC_1254 0550-0035 264 µM 1.28931354666925 0.119764264867632 no 442 0.0986445516605744 587 15121435 SGTC_2446 5162541 200 µM 1.28683446959767 0.12021808703327 no 443 0.0990759948880508 525 1549321 SGTC_192 3455-0609 60.9 µM 1.28415528167211 0.120709902465454 no 444 0.0995438142015214 539 3769639 SGTC_88 0180-0332 8.668 µM 1.28372191812917 0.120789587399561 no 445 0.0996196362611585 556 3101745 SGTC_2959 9079155 11 µM 1.28131167038758 0.121233448478591 no 446 0.10004210767191 485 16189457 SGTC_2760 etidronate 98.04 µM 1.28044222378684 0.121393843284938 no 447 0.100194826045285 539 3305 A chelator and antioxidant. SGTC_447 ml7 120 µM 1.2803396209227 0.121412781216171 no 448 0.100212859468078 557 4216 Selective myosin light chain kinase inhibitor. SGTC_579 4491-1009 110 µM 1.27841089620606 0.121769162284712 no 449 0.100552292045764 707 1271041 SGTC_2557 derrustone 83.84 µM 1.27672391866554 0.122081476434972 no 450 0.100849866979293 602 629853 An antioxidant. SGTC_2264 7948757 110.76 µM 1.27534809230834 0.12233660253812 no 451 0.101093031289695 536 2971411 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.27173574720982 0.123008237501014 no 452 0.10173351247535 493 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_658 3253-0951 102 µM 1.27033342092861 0.123269664028213 no 453 0.101982944099553 683 1184878 SGTC_896 0964-0007 44.5 µM 1.26992191199678 0.123346452781098 no 454 0.102056223537616 579 6756758 SGTC_2635 hydroquinidine 100 µM 1.2646770101146 0.12432810299356 no 455 0.10299356722753 572 442912 An experimental heart treatment. SGTC_1620 st003704 16.5 µM 1.25996126636131 0.125215367942524 no 456 0.103841667723253 582 2834414 SGTC_1301 naphtanilide LB 4.81 µM 1.25639672623254 0.125888961941506 no 457 0.104486084000471 606 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2086 5274770 176.623 µM 1.25438437917474 0.126270350853714 no 458 0.104851163761967 565 689278 SGTC_1696 st025591 34.7925 µM 1.25362963012277 0.126413601663912 no 459 0.104988328134895 590 2787147 SGTC_1492 4158-0558 28.5 µM 1.25294247693135 0.126544121268046 no 460 0.105113320888626 556 3967268 SGTC_259 usnic acid 108.925 µM 1.25281597870837 0.126568158885536 no 461 0.105136342572476 595 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2005 4024620 188 µM 1.2515976886103 0.126799825284153 no 462 0.105358248628325 572 236743 SGTC_1876 myriocin 605 nM 1.25128898994646 0.126858573350401 no 463 0.105414530464447 571 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1365 1672-3266 55.4 µM 1.25054803103879 0.126999661654711 no 464 0.105549710581326 608 6415873 SGTC_2033 5192550 145 µM 1.25033843013156 0.127039592228105 no 465 0.10558797278701 556 182073 SGTC_2833 9001315 45.46 µM 1.24801059603949 0.127483649814182 no 466 0.106013588412456 604 2989378 SGTC_825 1988-2224 89.6 µM 1.24631880995558 0.127807051406371 no 467 0.106323687455163 621 1180859 SGTC_873 0591-4978 488 µM 1.2453537928492 0.127991779100733 no 468 0.10650086517067 632 3305145 SGTC_3161 9100388 49.47 µM 1.24173746527836 0.128685681603101 no 469 0.10716672102052 586 25236368 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.24057903640562 0.12890851242418 no 470 0.107380650096875 689 368090 SGTC_2001 4023502 57.655 µM 1.23863397574909 0.129283258266026 no 471 0.10774053988766 594 108941 YCR052W RSC6 SGTC_1086 cerivastatin 2.18 µM 1.23567728024517 0.129854356216005 no 472 0.108289272992789 565 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2249 haloperidol 116.36 µM 1.23492396313741 0.130000141315585 no 473 0.108429402063459 713 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1971 st069429 63.5 µM 1.23409923267757 0.130159876494579 no 474 0.108582964717987 549 1246522 YGL099W LSG1 SGTC_815 1582-0027 36.9 µM 1.23251381026314 0.130467325144836 no 475 0.108878605514393 598 3128206 SGTC_122 0236-0016 402.397 µM 1.22870310038527 0.131208359778474 no 476 0.109591571678271 671 6808838 SGTC_1767 st044992 70.3 µM 1.22822004813743 0.131302501815808 no 477 0.109682187367958 600 9600693 SGTC_1352 1496-0991 99 µM 1.22752365228734 0.131438304458921 no 478 0.109812918800503 600 3000039 SGTC_448 monastrol 171 µM 1.22543578913158 0.13184603515388 no 479 0.11020553467455 595 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2049 5262831 67.185 µM 1.22333663183427 0.132256850226018 no 480 0.110601288362816 609 763417 SGTC_3301 9125354 19.7965 µM 1.22290139615939 0.132342138242316 no 481 0.11068347059089 535 41905162 SGTC_171 k064-0041 9.68 µM 1.22149045046979 0.132618885271643 no 482 0.110950189553796 502 53325 SGTC_2216 7189485 200 µM 1.22087429786731 0.132739864225539 no 483 0.111066808639201 606 731273 SGTC_2912 7964298 10.93 µM 1.21966578866943 0.13297737057713 no 484 0.111295797834057 667 2975850 SGTC_310 1273-0058 1.06 µM 1.21944381629945 0.13302102622928 no 485 0.111337894031905 805 2734232 SGTC_2528 xanthyletin 44.79 µM 1.21745746450758 0.133412124292914 no 486 0.111715105340139 578 65188 An natural product with antifungal activity of unknown mechanism. SGTC_3275 9138069 49.47 µM 1.21687019012487 0.133527905645965 no 487 0.111826804560389 580 17617007 SGTC_151 3013-0144 2.285 µM 1.21656472472746 0.133588155569184 no 488 0.111884935456068 623 906558 YHR107C CDC12 SGTC_1530 rhein 70.4 µM 1.21634249407301 0.133632000036986 no 489 0.111927240131168 650 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_400 oxethazaine 37.5 µM 1.21553890061004 0.133790625668799 no 490 0.112080310705956 587 4621 A local anesthetic. SGTC_1958 st076513 41.9 µM 1.21548470192926 0.133801328894886 no 491 0.11209063999613 614 732122 YGL099W LSG1 SGTC_837 0091-0265 12.5 µM 1.21108996222776 0.134671167070744 no 492 0.112930464002706 642 759367 SGTC_147 4466-0538 29.23 µM 1.20760943777295 0.135362805293381 no 493 0.113598763631208 635 6742687 YHR072W ERG7 SGTC_1262 0737-0114 49.6 µM 1.20634437414839 0.13561479674106 no 494 0.113842367292944 702 765919 SGTC_834 0312-0008 75.7 µM 1.20606552601567 0.135670384454191 no 495 0.113896112988652 646 6385573 YIL048W NEO1 SGTC_2964 9083345 53.42 µM 1.20461726010889 0.135959343854179 no 496 0.114175545209799 561 17741579 SGTC_515 4092-1064 102 µM 1.20440484382437 0.136001760760853 no 497 0.11421657038822 688 717353 SGTC_530 4358-1714 28 µM 1.202973927786 0.136287733068393 no 498 0.114493204999006 674 1564641 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.20236530391428 0.136409492767946 no 499 0.114611012840117 635 4213774 SGTC_2844 9010103 25.97 µM 1.2010361632566 0.136675655809257 no 500 0.114868586841617 617 2480525 SGTC_1160 4092-0570 10.5 µM 1.20101232067605 0.136680433572865 no 501 0.114873211048782 648 4994975 SGTC_97 0535-0701 19.132 µM 1.19690607865225 0.137504978351404 no 502 0.115671582313059 580 2832013 YGL099W LSG1 SGTC_3059 1327-0034 3 µM 1.19651121172623 0.137584447322901 no 503 0.115748562993795 630 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2479 5617353 43.85 µM 1.19484084170199 0.1379209645258 no 504 0.116074609943529 621 2731746 SGTC_3233 9132340 49.47 µM 1.19451179562858 0.137987321166211 no 505 0.116138914693288 600 17682950 SGTC_597 k018-0003 82.8 µM 1.19317986988441 0.138256144652584 no 506 0.116399468310426 686 6786234 SGTC_2506 ethyl hematommate 54.16 µM 1.1918172061367 0.138531541270752 no 507 0.116666463814342 546 3940691 An allergen. SGTC_3043 9092303 49.47 µM 1.18945018959377 0.139010807311794 no 508 0.117131280387537 580 25236084 SGTC_1245 0418-0076 17.2 µM 1.18624315828929 0.139661955710336 no 509 0.117763143479135 645 6790114 SGTC_2322 7413319 38.22 µM 1.18572811392121 0.139766722119165 no 510 0.117864844114993 755 1840400 SGTC_2409 alverine citrate 63.97 µM 1.18421889574317 0.140074023394089 no 511 0.118163212058435 630 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2387 9077560 195.08 µM 1.18164992793273 0.140598161913947 no 512 0.118672316982156 640 5303272 SGTC_2757 clomiphene 4.22 µM 1.18123050270221 0.140683862190006 no 513 0.11875558347769 732 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_449 xestospongin c 11.1929 µM 1.17954956291165 0.141027680779888 no 514 0.119089706586214 663 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_809 3998-0021 90 µM 1.17799470151831 0.141346218318414 no 515 0.119399359278115 616 715485 SGTC_1659 st012954 42.1 µM 1.17606722226618 0.141741768910351 no 516 0.119784007391477 623 24207262 SGTC_2842 9000675 19.48 µM 1.17593548550188 0.141768830816152 no 517 0.119810328667767 590 2989072 SGTC_2654 protoveratrine a 100 µM 1.17435407715693 0.142093963329936 no 518 0.120126615647292 630 5702278 A heart drug and vasodilator. SGTC_3182 9108849 49.47 µM 1.17200147409139 0.142578584262062 no 519 0.120598232162957 660 17133045 SGTC_2040 5100729 123 µM 1.1718824441675 0.142603133322709 no 520 0.120622128194766 656 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_181 1447-1644 8.07 µM 1.17174028870146 0.142632455604029 no 521 0.120650671197497 639 534600 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.17144784792938 0.142692789920791 no 522 0.120709404523217 701 4174840 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.16810357301611 0.143383984045334 no 523 0.121382494633275 565 61125 An anti-inflammatory. SGTC_3245 9134821 49.47 µM 1.16326084444999 0.14438887924632 no 524 0.122361843477085 663 17014901 SGTC_780 0109-0199 192 µM 1.1618691069513 0.144678549031299 no 525 0.12264431876727 701 610414 SGTC_2788 5282734 71.43 µM 1.1612857962936 0.144800072934228 no 526 0.122762846893986 721 743706 SGTC_1480 1070-0044 41.2 µM 1.16101127894717 0.144857288227972 no 527 0.122818656329842 660 3124987 SGTC_875 0709-0210 25.7 µM 1.15922570952836 0.14522981062356 no 528 0.123182097229879 694 6251364 SGTC_1410 3909-8106 77.9 µM 1.15779200054337 0.145529390748654 no 529 0.123474464320897 643 1039210 SGTC_1353 1498-1206 8.11 µM 1.15731976096143 0.145628158315278 no 530 0.123570871445647 724 6756808 SGTC_606 k015-0008 38.6 µM 1.15645551310333 0.145809029989281 no 531 0.12374744306606 712 1970475 SGTC_3356 9151811 4.48 µM 1.15569902983563 0.145967472326711 no 532 0.123902142571543 648 1859254 YPR165W RHO1 SGTC_76 0433-0009 400.328 µM 1.1553043333646 0.14605018580283 no 533 0.123982911023451 582 2841569 SGTC_354 2783-3500 4.88 µM 1.15496504737354 0.146121312497695 no 534 0.124052370032113 641 6740761 SGTC_1208 2323-2347 50.3 µM 1.15342623857604 0.146444194880385 no 535 0.124367738469055 692 5412760 SGTC_2218 6965428 192.983 µM 1.150907762048 0.146973669907628 no 536 0.124885092076193 657 675684 SGTC_347 4534-1311 26.2 µM 1.15086608674772 0.146982442350399 no 537 0.124893665779333 666 2862016 SGTC_1928 4'-methoxychalcone 40.3 µM 1.14808062597979 0.147569564042669 no 538 0.125467640673594 670 641818 SGTC_2513 baicalein 25.65 µM 1.14793723941136 0.147599829639067 no 539 0.125497236799493 661 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1865 st057639 52.2 µM 1.14707652323215 0.147781594352732 no 540 0.125674997855134 662 688818 SGTC_3163 9099914 49.47 µM 1.14690490350794 0.147817854655763 no 541 0.125710462941941 618 16268368 SGTC_2800 7887935 81.82 µM 1.14546898062016 0.148121473946984 no 542 0.126007468926763 646 2961002 SGTC_2924 9010168 62.78 µM 1.14450237654435 0.148326092787111 no 543 0.1262076764316 682 2993929 SGTC_2961 9083290 32.55 µM 1.14427781085947 0.14837365778438 no 544 0.126254221235411 609 17741490 SGTC_889 0919-1524 82.7 µM 1.14194399368172 0.1488685848179 no 545 0.126738650172899 635 3905452 SGTC_1289 0976-0073 69.1 µM 1.14077274750889 0.149117383469633 no 546 0.126982252133679 710 3391136 SGTC_1077 5-fluorocytosine 377 nM 1.1390736744497 0.149478797640591 no 547 0.127336213283692 638 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1800 st050079 29.0735 µM 1.13567599635574 0.150203278633199 no 548 0.12804609503854 809 3645560 SGTC_2948 9070189 9.45 µM 1.13505429373305 0.150336096078027 no 549 0.128176285223812 607 6473636 YDL196W YDL196W SGTC_3197 9113331 49.47 µM 1.13371731756863 0.150621986025789 no 550 0.128456571545853 678 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.13240645991191 0.150902642278133 no 551 0.128731795120759 713 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3311 9131146 2.8755 µM 1.13156368391737 0.151083265386021 no 552 0.128908957652941 687 4900406 YPR165W RHO1 SGTC_2349 9023730 187.07 µM 1.1292964723577 0.15156988621278 no 553 0.129386394270545 664 4126287 SGTC_721 1187-1332 279 µM 1.12892891247934 0.1516488751241 no 554 0.129463911480214 607 25730 SGTC_2636 apigenin dimethyl ether 100 µM 1.12884398271908 0.151667130488097 no 555 0.129481827472289 685 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_897 1000-0139 31.4 µM 1.12825493127907 0.151793785292608 no 556 0.129606135558032 680 6151020 SGTC_438 sphingosine 6.67 µM 1.12738891695704 0.151980118809986 no 557 0.129789041451202 577 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2014 4013930 200 µM 1.1268569734093 0.152094648228915 no 558 0.129901478755779 758 64556 SGTC_1205 4161-2785 76 µM 1.12633525067288 0.152207032730329 no 559 0.130011821167027 615 3498106 SGTC_2415 st077333 57.7 µM 1.12579770913796 0.152322882420327 no 560 0.130125577034961 771 2766255 SGTC_3345 9148410 3.559 µM 1.12546520893529 0.152394571376494 no 561 0.130195976020061 659 4903596 SGTC_268 camptothecin 39.6153 µM 1.12275776765156 0.152979144737548 no 562 0.130770193104307 780 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1697 st025554 27.742 µM 1.12200533255857 0.153141869336209 no 563 0.130930086295718 636 1269519 SGTC_519 k048-0011 62.8 µM 1.12138607015994 0.153275879507101 no 564 0.131061781466254 667 6836379 SGTC_3294 9122953 26.2835 µM 1.11089143795403 0.155558762342927 no 565 0.13330754067899 702 16459826 SGTC_2592 piperlongumine 83.33 µM 1.11035610151769 0.155675811506199 no 566 0.133422803427609 635 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1511 0906-3109 28.5 µM 1.10926066041096 0.155915506297157 no 567 0.133658875359676 790 2882180 SGTC_93 0109-0045 59.227 µM 1.10827883179727 0.156130548037453 no 568 0.133870707266194 803 88733 SGTC_2312 7706453 155.7 µM 1.10730342246244 0.156344377243525 no 569 0.134081382568926 684 976098 SGTC_1021 4476-0760 85.3 µM 1.10711077393744 0.156386632446923 no 570 0.134123018982166 683 746768 SGTC_251 melphalan 456.522 µM 1.10335060581548 0.157212887372113 no 571 0.134937469037753 789 460612 A DNA alkylator. SGTC_3250 9135583 49.47 µM 1.10299725862827 0.157290678742256 no 572 0.135014177820707 676 7699353 SGTC_1177 0983-0204 23.6 µM 1.10287509509974 0.157317579616011 no 573 0.135040705479237 753 766818 SGTC_2201 6605497 169.863 µM 1.10188163323338 0.157536456001681 no 574 0.135256567222418 692 670741 SGTC_923 1900-2434 73.3 µM 1.10177353019407 0.157560284988648 no 575 0.135280070368711 690 5910570 SGTC_1277 0873-0036 22 µM 1.09741655301208 0.158522658037992 no 576 0.136229670321373 745 5965735 SGTC_1058 3448-5425 97.3 µM 1.09067511652074 0.160019293942726 no 577 0.137707931809204 684 7279705 SGTC_1653 st012112 65 µM 1.0885695407446 0.16048863084709 no 578 0.138171877420554 677 720429 SGTC_325 2810-4341 181 µM 1.08754956477263 0.160716308478726 no 579 0.138397003146627 722 774970 SGTC_1148 3909-7663 27.7 µM 1.08656812588213 0.160935582939078 no 580 0.138613858977292 740 4084526 SGTC_1570 verbenone 133 µM 1.0865005251 0.160950693586358 no 581 0.138628804362936 756 29025 A natural terpanoid with antifungal properties. SGTC_664 1222-0054 14.9 µM 1.08499902014184 0.161286560244627 no 582 0.138961044625226 729 6813991 SGTC_2373 9071805 200 µM 1.08225046261447 0.161902559481339 no 583 0.13957062557232 731 10149009 SGTC_558 k064-0027 21.3 µM 1.08085541656808 0.162215799042633 no 584 0.139880716572035 734 5088526 SGTC_712 r015-0009 80.6 µM 1.0785951790713 0.162724143138137 no 585 0.140384115682946 665 6813872 YLR060W FRS1 SGTC_2799 7812892 81.82 µM 1.07824460565602 0.162803082407161 no 586 0.140462305301115 767 20205235 SGTC_1488 4013-0813 75.9 µM 1.07557359157839 0.163405337161753 no 587 0.141059001673221 687 2910057 SGTC_2821 7996764 71.43 µM 1.07532325121625 0.16346185747034 no 588 0.141115014922339 744 2987135 SGTC_184 1494-0393 24.714 µM 1.07511241750621 0.16350946805829 no 589 0.1411622003208 739 3090647 SGTC_1458 k015-0034 6.33 µM 1.07473044781721 0.163595747605128 no 590 0.141247713857026 688 3598957 SGTC_1429 4049-0205 9.46 µM 1.07414824087384 0.163727313722957 no 591 0.141378123092864 792 22774478 SGTC_245 methotrexate 289.6 µM 1.07331661730491 0.163915361666495 no 592 0.141564540951131 778 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_538 2922-0838 53.3 µM 1.07277385364718 0.16403816773568 no 593 0.141686297360266 802 777039 SGTC_3209 9113616 49.47 µM 1.07056457061724 0.16453865736678 no 594 0.142182630506924 780 16649353 SGTC_42 0133-0086 60.653 µM 1.06908932447694 0.164873409196628 no 595 0.142514710791499 652 162923 Model of phenazepam hydroxylation. SGTC_3256 9138902 49.47 µM 1.06819341532062 0.16507691732691 no 596 0.14271663719716 764 17228773 SGTC_1895 st058434 18.3 µM 1.06561098675316 0.165664432333234 no 597 0.143299765299809 767 5393175 SGTC_3327 9140648 26.9345 µM 1.06335467241246 0.166178860151296 no 598 0.143810570133004 715 8029710 SGTC_1464 k208-0027 110 µM 1.06027341695765 0.166883035104106 no 599 0.144510114621551 766 X1464 SGTC_2903 5923464 63.88 µM 1.05958905364386 0.167039696974443 no 600 0.144665797840441 718 2876576 SGTC_1561 5-methoxyflavone 52.9 µM 1.05717753471557 0.167592488382703 no 601 0.145215285318592 693 94525 SGTC_2969 9091408 28.7 µM 1.05590130765734 0.167885513614205 no 602 0.145506653324645 706 4286311 SGTC_1022 4477-0945 21.3 µM 1.05535197479705 0.168011743419345 no 603 0.145632189281468 740 4648966 SGTC_1802 st050112 57.9 µM 1.05382343005259 0.168363305198129 no 604 0.145981882160578 747 4662563 SGTC_2132 5317594 122.667 µM 1.05304311983841 0.168542957028199 no 605 0.146160615002603 687 794577 SGTC_82 0054-0107 293.755 µM 1.0516927156088 0.168854153419569 no 606 0.146470277074979 753 3104697 SGTC_1150 3909-7983 10.9 µM 1.05128735073043 0.168947640471778 no 607 0.146563317438779 758 23965914 SGTC_308 4092-1169 104 µM 1.0507788980052 0.169064949099863 no 608 0.146680074852548 789 2268590 YDL196W YDL196W SGTC_3318 9139014 38.6185 µM 1.0496647552886 0.169322183485489 no 609 0.146936136711973 717 16643984 SGTC_298 1391-0729 10 µM 1.04932729937626 0.16940014518773 no 610 0.147013752851042 731 3237558 SGTC_3140 9094243 49.47 µM 1.04839056097909 0.169616678524705 no 611 0.147229350297287 792 19291112 SGTC_1466 k213-0079 57.5 µM 1.04802880680704 0.169700347921482 no 612 0.147312667462676 766 3657981 SGTC_1452 4194-0072 190 µM 1.04729628880643 0.169869851598083 no 613 0.147481473606192 830 1343545 SGTC_2837 9008476 45.46 µM 1.04692573145607 0.169955639401428 no 614 0.147566916561007 755 2992805 SGTC_1154 4088-0362 150 µM 1.04467233897899 0.170477920564104 no 615 0.148087216683038 811 6618304 SGTC_2428 5615643 7.78 µM 1.04323207594478 0.170812276065904 no 616 0.148420410517919 722 2253075 SGTC_2357 9067248 200 µM 1.04274945147627 0.170924410622704 no 617 0.148532174065175 713 9150235 SGTC_1221 2958-7315 257 µM 1.04134148000456 0.171251812396278 no 618 0.148858545914197 740 4562705 SGTC_2050 5263056 171 µM 1.0407367568751 0.171392554324411 no 619 0.148998869482917 833 763468 YGL055W OLE1 SGTC_2164 5685496 200 µM 1.03924434547219 0.171740211144826 no 620 0.149345555591058 784 759046 SGTC_360 0957-0399 1.01 µM 1.03452451568799 0.172842656508969 no 621 0.150445510966959 793 6752301 YPR165W RHO1 SGTC_3222 9128301 49.47 µM 1.03434759542532 0.172884068584579 no 622 0.150486846877552 775 4911358 SGTC_293 4049-0273 38.5 µM 1.03250936178672 0.173314721650125 no 623 0.150916782153657 723 1380311 SGTC_1718 roemerine 11.9335 µM 1.03067670052246 0.173744748531551 no 624 0.151346227213645 780 235224 An aporphine alkaloid with mutagenic activity. SGTC_2846 9008642 19.48 µM 1.02675647547383 0.174666890701664 no 625 0.152267574404091 709 2992898 SGTC_2700 st077718 96.8 µM 1.02599248641572 0.17484696258703 no 626 0.152447562847898 725 904970 SGTC_2419 paclitaxel 166.5 µM 1.02138194028336 0.175936166007689 no 627 0.153536759132565 802 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_10 0279-0212 42.575 µM 1.02130002052325 0.175955557643338 no 628 0.15355615835531 877 39851 YBR002C RER2 SGTC_2276 7947513 42.08 µM 1.0211424768975 0.17599285438607 no 629 0.153593470447302 693 2105100 SGTC_689 0833-0039 98 µM 1.02032404942404 0.176186688742392 no 630 0.153787400599593 818 5374726 SGTC_1848 st056003 16.4 µM 1.01667930148659 0.177051541779383 no 631 0.15465300772958 818 146492 SGTC_1283 0922-0125 16.4 µM 1.01657447852602 0.177076454568859 no 632 0.154677950130097 836 3360884 SGTC_1207 2099-0101 141 µM 1.01558895057246 0.177310788731335 no 633 0.154912584383636 838 5837381 SGTC_1045 1348-1485 165 µM 1.01538255633606 0.177359888961435 no 634 0.154961752428503 876 6810614 SGTC_3029 9088683 49.47 µM 1.01503553858293 0.177442462221824 no 635 0.155044443588371 767 25236615 SGTC_1017 4239-0030 168 µM 1.0135200020179 0.177803370206249 no 636 0.155405923545148 787 1149593 SGTC_317 4495-0002 170 µM 1.01049717680362 0.178524603753915 no 637 0.156128575674842 742 15991618 SGTC_55 0767-0285 6.563 µM 1.00782541759585 0.179163606253412 no 638 0.15676914069068 826 3116166 SGTC_3248 9135562 49.47 µM 1.00557575525604 0.179702770446305 no 639 0.157309845692518 841 17650701 SGTC_2571 chrysanthemic acid 100 µM 1.00393190165188 0.180097387717751 no 640 0.157705719250824 735 2743 An insecticide. SGTC_2755 lomerizine 42.69 µM 1.00031628672016 0.180967250942886 no 641 0.158578733907671 811 3949 A calcium channel blocker. SGTC_1330 1469-0054 61.8 µM 0.999872939870709 0.181074094522247 no 642 0.15868600071622 865 7102664 SGTC_1870 st057514 26.5 µM 0.997870163388358 0.18155724240723 no 643 0.159171160853352 780 5393161 SGTC_2200 6600604 21.907 µM 0.988739660946601 0.18377008528006 no 644 0.161395266373144 826 2904777 SGTC_2197 6588183 93.1375 µM 0.986232314919071 0.184380686798534 no 645 0.162009562611861 787 884136 SGTC_757 1066-0008 322 µM 0.985984103741886 0.184441201016312 no 646 0.162070456735081 842 6842497 SGTC_1834 st055981 52.8 µM 0.985961339101316 0.184446751684648 no 647 0.1620760423741 830 471719 YDL150W RPC53 SGTC_3193 9111931 49.47 µM 0.982572900969943 0.185274108037599 no 648 0.16290884355565 823 17087244 SGTC_882 0843-0131 351 µM 0.981114739345261 0.185630856088616 no 649 0.163268081361178 869 5425421 SGTC_2855 9016525 58.44 µM 0.979482367815464 0.18603073091717 no 650 0.16367084826737 816 43811474 SGTC_2684 capsaicin 100 µM 0.977353506435916 0.186553030333123 no 651 0.164197086056444 794 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_636 0kpi-0074 126 µM 0.976785531717597 0.186692531777634 no 652 0.164337670165603 791 616434 SGTC_213 1246-0773 967 nM 0.973625172718344 0.18746993292339 no 653 0.165121341420284 854 6251622 SGTC_2341 7987486 176.74 µM 0.97311369272618 0.187595937205489 no 654 0.165248399704062 859 1258686 SGTC_139 0099-0334 718.624 µM 0.972284248582606 0.187800383897355 no 655 0.165454578882999 964 97690 SGTC_2225 6654152 15.4 µM 0.969293339548054 0.18853874434228 no 656 0.166199425749632 776 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_8 0354-0001 70 µM 0.96903492208197 0.188602623308734 no 657 0.166263882745662 922 4993152 SGTC_369 0957-0393 4.5 µM 0.965876269756388 0.189384497735105 no 658 0.167053048998107 778 6997992 SGTC_2429 5902844 64.44 µM 0.962257860852447 0.190282625377416 no 659 0.16796004537363 885 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1651 st011928 86.1 µM 0.961419213087801 0.19049115957239 no 660 0.168170713823438 834 720198 SGTC_270 tamoxifen 5.46 µM 0.960320018356231 0.190764692542228 no 661 0.168447089028794 907 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_3185 9108267 49.47 µM 0.95865324165295 0.191179927008009 no 662 0.168866730658134 832 4910486 SGTC_1103 duloxetine 36.1 µM 0.957063014456542 0.191576607252432 no 663 0.169267725088236 928 60835 A selective serotonin reuptake inhibitor. SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.954651759221624 0.192179052956147 no 664 0.169876916491344 828 5377381 SGTC_1201 1889-3372 45.9 µM 0.954597215618587 0.192192693921353 no 665 0.169890712894928 822 5392199 SGTC_1358 1509-0022 2.48 µM 0.953758851519524 0.192402437302533 no 666 0.170102861309012 875 3258434 SGTC_2736 butenafine 14.65 µM 0.952502465197874 0.19271702412715 no 667 0.170421108151368 869 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_338 4055-0136 114 µM 0.952321672198475 0.192762318776362 no 668 0.170466934985583 844 2900563 SGTC_3091 9116372 49.47 µM 0.951710950191468 0.192915373006833 no 669 0.170621797204631 808 17169793 SGTC_34 0469-0683 81.75 µM 0.951601341603422 0.192942850082405 no 670 0.170649600442562 864 3690923 SGTC_1123 mangostin 811.285 nM 0.947214194035621 0.194044597605091 no 671 0.171764822000722 820 5281650 An antioxidant. SGTC_961 1252-1571 372 µM 0.945691029567096 0.194428005630813 no 672 0.172153099590127 870 6813498 SGTC_2627 acetyl isogambogic acid 100 µM 0.943907293107217 0.194877590124053 no 673 0.172608512409474 812 6857789 A caspase activator and apoptosis inducer. SGTC_1930 st074634 34.3 µM 0.941619434736582 0.195455161380412 no 674 0.173193757964888 840 684253 YOR116C RPO31 SGTC_584 0986-0246 15.4 µM 0.941070221712504 0.19559396514004 no 675 0.173334437261939 942 53315 YDR232W HEM1 SGTC_3181 9108277 49.47 µM 0.940669093701138 0.195695380874028 no 676 0.173437230977279 828 17097298 SGTC_2345 9052315 157.45 µM 0.940563621993568 0.195722052200801 no 677 0.173464265769647 822 6469265 SGTC_994 3910-0338 138 µM 0.939574099011472 0.195972386851365 no 678 0.173718033581288 895 3479481 SGTC_1128 3448-9350 235 µM 0.939531054152298 0.19598328096977 no 679 0.173729077994994 768 619386 SGTC_544 k015-0020 52.4 µM 0.938016365839395 0.196366863627184 no 680 0.174117999827565 847 3008304 SGTC_3118 9124250 49.47 µM 0.937684431763048 0.196450984017043 no 681 0.174203303385541 776 1504786 SGTC_3037 9091026 49.47 µM 0.936573263461397 0.196732740710801 no 682 0.174489055152666 948 25236398 YIL048W NEO1 SGTC_2391 6285546 200 µM 0.934531279379365 0.197251160207272 no 683 0.175014954385725 878 846083 SGTC_1643 st009866 20.2 µM 0.934111157454187 0.197357923297358 no 684 0.175123278562006 880 3156273 YOR207C RET1 SGTC_2890 9046729 58.44 µM 0.933503684731244 0.197512358521532 no 685 0.175279984428858 809 903329 SGTC_2108 5365811 200 µM 0.932372212041919 0.197800202756731 no 686 0.175572100194154 907 780283 SGTC_2778 tioconazole 65.09 nM 0.931902899930595 0.197919669085399 no 687 0.175693354408127 837 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2280 7785178 200 µM 0.929971747048125 0.198411714599223 no 688 0.176192856480976 856 2954328 SGTC_3156 9099931 49.47 µM 0.927750555939853 0.198978571798896 no 689 0.176768488606361 925 18111053 SGTC_2697 mebhydrolin 72.4 µM 0.927000289368534 0.199170263228002 no 690 0.176963192020585 910 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3077 9117319 49.47 µM 0.92348519855795 0.200069841516988 no 691 0.177877205175595 847 17154678 SGTC_1565 sinapyl alcohol 95.1 µM 0.923433770663523 0.200083020991867 no 692 0.177890599800169 852 5280507 A phenol propionate derived from cinnamic acid. SGTC_1864 st057645 30.4 µM 0.923385664434235 0.200095349692903 no 693 0.177903129858063 879 688666 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.923368685696586 0.200099701125727 no 694 0.177907552382169 863 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2905 7799065 20.05 µM 0.921405536343077 0.200603214574696 no 695 0.178419369683102 852 1296806 SGTC_37 0566-0070 1.56 µM 0.920216576650188 0.200908531468841 no 696 0.17872979674022 937 1626686 SGTC_2204 7233102 200 µM 0.919142240092594 0.201184653560558 no 697 0.179010588954994 845 2172480 SGTC_2907 7721985 69.9 µM 0.918642900988469 0.201313069313664 no 698 0.179141192337915 876 3267881 SGTC_2343 7990716 14.84 µM 0.9182737018701 0.201408048368434 no 699 0.179237795816894 895 6456862 SGTC_2401 5128683 200 µM 0.916146369065234 0.201955842614004 no 700 0.179795065103522 827 708373 SGTC_2558 carylophyllene oxide 100 µM 0.915133108021209 0.202217073469803 no 701 0.180060877972078 941 6708694 An oxygenated terpenoid and antifungal agent. SGTC_629 3448-6466 76.7 µM 0.914852559820933 0.202289437879642 no 702 0.180134518908344 916 573744 SGTC_2567 aureobasidin a 60 nM 0.91377390916945 0.202567808515143 no 703 0.180417829347806 854 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_346 4513-0042 7.16 µM 0.913068280827584 0.202750035984856 no 704 0.180603315659125 901 2827372 SGTC_925 2064-1272 59.6 µM 0.912884041458475 0.202797631649095 no 705 0.18065176576688 829 6815817 SGTC_2687 chenodiol 100 µM 0.912416665143589 0.202918401725363 no 706 0.180774710001835 834 5702181 A cholesterol synthesis inhibitor. SGTC_3053 9095903 49.47 µM 0.911758763681529 0.20308847628905 no 707 0.18094786110306 935 17174018 SGTC_1478 0453-0656 35.7 µM 0.911477463332795 0.203161221404289 no 708 0.181021927402393 918 5258496 SGTC_2143 5623677 140.463 µM 0.909587189196902 0.203650455293273 no 709 0.18152012860949 881 5375313 SGTC_1339 1486-1321 22.7 µM 0.909245203917707 0.203739041666868 no 710 0.181610353943232 897 3469382 SGTC_2309 7664088 163.95 µM 0.908836895053244 0.203844838294786 no 711 0.181718114053946 951 704922 SGTC_1917 st066507 28.5 µM 0.908804638644561 0.203853197625901 no 712 0.181726628809585 902 3156428 SGTC_750 4073-0104 132 µM 0.908785497310095 0.203858158248458 no 713 0.18173168168431 760 22330957 SGTC_78 0336-0123 156.75 µM 0.907847350639661 0.204101374264857 no 714 0.181979438677398 827 6765896 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.906646564837026 0.204412931970784 no 715 0.182296864573186 911 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2657 nystatin 74.44 µM 0.905009854770333 0.204838050849166 no 716 0.182730083204606 923 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3145 9085516 49.47 µM 0.904679116487327 0.204924020583765 no 717 0.182817703887067 860 25236195 SGTC_1839 st053978 48 µM 0.902725023247605 0.205432391186717 no 718 0.183335926171588 909 3788398 SGTC_2872 9044037 25.97 µM 0.902065428951863 0.205604158038301 no 719 0.183511056045266 891 6465195 SGTC_555 4296-0685 37 µM 0.901179486655202 0.205835002935886 no 720 0.183746447937807 940 2908540 YHR072W ERG7 SGTC_51 1013-0126 23.419 µM 0.900888687484628 0.205910808314762 no 721 0.183823753286452 887 1627850 SGTC_511 blebbistatin 171 µM 0.898127842946088 0.206631328468637 no 722 0.184558698348352 908 3476986 A myosin inhibitor. SGTC_2957 9076800 11.52 µM 0.893663843151391 0.20779948870217 no 723 0.185750888168684 833 16459615 SGTC_2138 5575593 77.673 µM 0.890850404404432 0.208537722049842 no 724 0.1865047150789 920 762213 SGTC_2452 5863136 48.41 µM 0.890445027076899 0.208644218500195 no 725 0.186613486986066 931 2184096 SGTC_1720 st037298 9.481 µM 0.887491011610145 0.209421233711369 no 726 0.18740730165517 876 597396 SGTC_40 0327-0103 19.753 µM 0.88599298964187 0.209815918614559 no 727 0.187810652428245 887 409036 SGTC_719 2810-4230 27.3 µM 0.885734555289135 0.209884052694027 no 728 0.187880291505292 918 721079 SGTC_1640 st009078 66.4 µM 0.885594527340622 0.209920975335839 no 729 0.187918030830572 879 690618 SGTC_2406 ethylparaben 405.7 µM 0.881636434931071 0.210966225275607 no 730 0.188986722710981 775 8434 A possible steroid mimic. SGTC_1701 st028638 40.4 µM 0.880710087034701 0.211211294405787 no 731 0.189237377879254 953 3490878 SGTC_1754 st042065 16.137 µM 0.880403928925006 0.21129232644837 no 732 0.189320264429695 985 1126236 YIL048W NEO1 SGTC_2822 7994718 71.43 µM 0.879464970772786 0.211540957660029 no 733 0.189574609032727 836 1018011 SGTC_771 0250-0039 27.3 µM 0.878065858544779 0.211911752874159 no 734 0.189953989780686 905 3005115 SGTC_3137 9097352 49.47 µM 0.876534033867017 0.212318155456946 no 735 0.1903698914041 971 44120435 SGTC_1394 3474-0001 65.7 µM 0.871983964931722 0.213527999562478 no 736 0.191608562673241 831 5017666 YIL048W NEO1 SGTC_2177 5811945 192 µM 0.871348142970395 0.213697381274171 no 737 0.19178204560128 958 5343475 SGTC_3008 9078912 71.4286 µM 0.871165633855731 0.213746015794608 no 738 0.191831860658831 914 16648731 SGTC_165 k038-0023 64.381 µM 0.869370375825797 0.214224754634676 no 739 0.192322290519865 971 46368543 SGTC_1629 st005085 44.9 µM 0.868070683647704 0.214571730600016 no 740 0.192677819405492 929 24207091 SGTC_2127 5253358 187.912 µM 0.868000821806403 0.214590390709685 no 741 0.19269694137727 855 20612 SGTC_1080 nisoldipine 24.4 µM 0.867863937631712 0.214626955230591 no 742 0.192734411477463 950 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2256 7954252 200 µM 0.867320757911572 0.214772085167836 no 743 0.192883143096054 817 2972920 SGTC_3169 9102970 49.47 µM 0.867102713100734 0.214830359691439 no 744 0.19294286709698 984 17027839 SGTC_1418 3966-3099 2.4 µM 0.866791773427969 0.214913477126778 no 745 0.19302805518564 961 740335 SGTC_47 0149-0135 24.25 µM 0.864412436652959 0.21555011681875 no 746 0.193680681670797 975 5239155 SGTC_21 0849-0113 22.993 µM 0.862976592357572 0.215934834587906 no 747 0.194075168459934 949 1560156 SGTC_1621 st003705 32.4 µM 0.862830664106661 0.215973956624053 no 748 0.194115288469421 1010 24207032 SGTC_697 0508-1955 564 µM 0.861449399332373 0.216344464476299 no 749 0.19449528935788 1000 6243113 SGTC_1611 st001856 99.4 µM 0.861390351356274 0.216360311589792 no 750 0.194511544180375 917 647478 SGTC_128 0906-2981 13.371 µM 0.861124313832827 0.216431718251238 no 751 0.194584789674619 891 6740226 SGTC_3009 9080819 71.4286 µM 0.85998767357893 0.216736955425835 no 752 0.194897918656385 952 17027216 SGTC_2339 9000433 200 µM 0.858408944666905 0.21716132530634 no 753 0.195333345103296 882 2988954 SGTC_2489 cantharidin 73.42 µM 0.856644452320711 0.217636196870174 no 754 0.195820705419537 948 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2882 9058044 58.44 µM 0.85516991855327 0.218033492104073 no 755 0.19622854341127 969 18076804 SGTC_3216 9129716 49.47 µM 0.853534788771269 0.218474546488613 no 756 0.196681402005238 901 8056934 SGTC_3332 9141069 11.198 µM 0.853044437140526 0.218606912356108 no 757 0.196817330996972 910 17332883 SGTC_3299 9121982 43.1275 µM 0.851655881879745 0.218981990324623 no 758 0.197202556988276 979 17594604 YPL160W CDC60 SGTC_1759 st043059 70 µM 0.850922753984836 0.219180172794822 no 759 0.197406132067668 974 669426 SGTC_2841 9004761 38.96 µM 0.850476851914811 0.219300761484543 no 760 0.197530012363247 936 2991039 SGTC_3036 9090181 49.47 µM 0.846526078939085 0.220370863357853 no 761 0.198629665902718 959 25236586 SGTC_2171 5739187 198.077 µM 0.84539790304303 0.22067698831131 no 762 0.198944357455863 956 2262761 SGTC_1939 st074455 53.6 µM 0.843893059105977 0.221085699175156 no 763 0.199364583564746 977 1644229 SGTC_2053 5265679 138 µM 0.843558136402989 0.221176722019014 no 764 0.199458183041305 1000 764595 SGTC_976 1348-1067 47.6 µM 0.842510687099684 0.221461528465885 no 765 0.199751080095585 1073 5310671 YGL099W LSG1 SGTC_765 1319-0117 244 µM 0.841056369999881 0.22185731163395 no 766 0.20015817787826 991 3487746 YGL099W LSG1 SGTC_898 1000-0849 28.3 µM 0.838089737133629 0.222665913215805 no 767 0.200990153197516 1018 6751807 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.83762450472055 0.222792871694369 no 768 0.201120812903655 907 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_423 5-fluorouracil 457 µM 0.837278859515185 0.222887222411456 no 769 0.201217919726239 927 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_429 1112-0049 25.5 µM 0.836522099576055 0.223093874509925 no 770 0.20143062474876 914 2836170 SGTC_2191 5911152 200 µM 0.836375603860944 0.223133891404005 no 771 0.201471816346837 994 2875902 SGTC_2055 5235184 200 µM 0.834405337342433 0.223672488027126 no 772 0.20202630530858 965 2836034 SGTC_1321 1326-2144 215 µM 0.833456785778035 0.223932049658396 no 773 0.20229358004366 1007 3513030 SGTC_416 estradiol valerate 100 µM 0.831877164497257 0.224364676803727 no 774 0.202739141279098 990 13791 A steroid. SGTC_2598 perillyl alcohol 100 µM 0.83150631297759 0.224466314451014 no 775 0.202843831703567 1003 10819 An apoptosis inducer. SGTC_1857 st056007 79.3 µM 0.828717379144599 0.225231501871209 no 776 0.203632174637563 993 619834 SGTC_2162 5663267 200 µM 0.826556627747193 0.225825352014701 no 777 0.204244204581999 1034 6456493 SGTC_3092 9117248 49.47 µM 0.825926353722605 0.225998740063851 no 778 0.204422935003502 1063 17141857 SGTC_1265 0819-1001 68.8 µM 0.825912055594481 0.226002674344112 no 779 0.204426990685372 981 3106768 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.823814645349142 0.226580218076891 no 780 0.205022442387582 986 6710655 SGTC_2172 5754775 163.918 µM 0.823371365943208 0.226702386233089 no 781 0.205148420606854 934 2263357 SGTC_1771 st048882 4.1505 µM 0.82040188019396 0.22752173677529 no 782 0.205993521994369 1030 4580403 SGTC_193 1273-0060 1.558 µM 0.820090180746923 0.227607838548375 no 783 0.206082349744528 892 2847393 YHR072W ERG7 SGTC_157 1348-1695 65.819 µM 0.819880204719391 0.227665851264159 no 784 0.206142201273453 991 5380510 SGTC_657 3534-0529 86.7 µM 0.819768788005466 0.227696637139791 no 785 0.206173963658061 1031 1049549 SGTC_3307 9126885 69.2785 µM 0.819241085232505 0.227842480054258 no 786 0.206324439189266 992 24824909 SGTC_2922 7999257 32.47 µM 0.817965048373583 0.228195359612036 no 787 0.20668857259644 954 2988377 SGTC_2251 lansoprazole 556 µM 0.817307946225673 0.228377196653996 no 788 0.206876233423606 840 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2106 5357045 167.29 µM 0.817227914204517 0.228399349131012 no 789 0.206899096537178 1002 668842 SGTC_331 k048-0133 24.5 µM 0.816360170346463 0.22863961394486 no 790 0.207147084889671 984 6813582 SGTC_1479 0549-0158 134 µM 0.812696875043797 0.229655486476453 no 791 0.208195936666285 1077 5440202 SGTC_3322 9139058 2.11 µM 0.811480890166613 0.229993250665978 no 792 0.208544781386385 1011 4908926 YPR165W RHO1 SGTC_177 1327-0068 8.361 µM 0.811386928671592 0.230019361922238 no 793 0.208571751626574 1003 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_24 0417-1663 219 µM 0.810552876200721 0.230251212099869 no 794 0.208811244025872 1037 4329390 SGTC_281 1672-3440 14.9 µM 0.80862448299452 0.230787767592302 no 795 0.20936558883808 1065 6833000 SGTC_2404 5161160 200 µM 0.807523671578332 0.231094369830265 no 796 0.209682421080481 1033 2831543 SGTC_1247 0448-0043 5.84 µM 0.807290185002478 0.231159430620006 no 797 0.209749658711524 1035 3089013 YGL099W LSG1 SGTC_1636 st007707 68.9 µM 0.804471390718016 0.23194569070814 no 798 0.210562392768153 1057 403051 SGTC_963 1269-2853 151 µM 0.80403267895494 0.23206819651916 no 799 0.210689051132528 1009 3668223 SGTC_1175 0741-0056 27.6 µM 0.803918385594768 0.232100117694304 no 800 0.210722055556632 1101 765927 SGTC_1520 flindersine 88 µM 0.801941253504312 0.232652700749785 no 801 0.211293470645271 1075 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2772 vinpocetine 57.06 µM 0.801629081091863 0.232740015732394 no 802 0.211383775152875 1010 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3171 9103192 49.47 µM 0.801013742659656 0.232912179914649 no 803 0.211561844999716 1103 13018434 SGTC_924 2046-0044 21.3 µM 0.800394732069269 0.233085442876956 no 804 0.211741066093525 1079 3623589 SGTC_2310 7668677 200 µM 0.79853447630488 0.233606564617248 no 805 0.212280197238567 1027 2197143 SGTC_1645 Cervolide 78 µM 0.798467035898472 0.233625469126284 no 806 0.212299757579173 990 23173 A fragrance. SGTC_359 0081-0058 15.9 µM 0.798419844056588 0.233638698177955 no 807 0.21231344567503 993 3494159 SGTC_872 0588-0139 234 µM 0.79809744004989 0.233729087181874 no 808 0.212406973452153 1074 2047100 SGTC_836 0330-0104 1.35 µM 0.796670834846069 0.234129281968517 no 809 0.212821113262153 1084 46494820 SGTC_1204 4049-0315 18.3 µM 0.796507261060035 0.234175192322515 no 810 0.212868628411319 996 588402 SGTC_2642 cholecalciferol 100 µM 0.795660998985522 0.234412792797433 no 811 0.213114550697751 1051 9821465 A vitamin D precursor, similar to steriods. SGTC_3127 9126946 49.47 µM 0.79533491626271 0.234504380889574 no 812 0.213209353983173 924 27243249 SGTC_3120 9124077 49.47 µM 0.79497143012867 0.234606497948223 no 813 0.213315060688785 1130 18774327 YGL155W CDC43 SGTC_1372 2752-0194 270 µM 0.794935142483804 0.234616693875697 no 814 0.213325615306103 980 823334 SGTC_1698 5-fluorocytosine 1.055 µM 0.794084057464541 0.234855897903418 no 815 0.213573249029375 1065 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2510 benzyl isothiocyanate 8.31 µM 0.793554643891043 0.235004761659073 no 816 0.213727372927246 1013 2346 DNA damaging agent; causes G2/M arrest. SGTC_1166 k206-0078 225 µM 0.793451448034761 0.235033784972918 no 817 0.213757423046353 1087 5404595 SGTC_1273 0849-0096 14.1 µM 0.793375781875938 0.235055066956475 no 818 0.213779458218302 1018 5286025 SGTC_1804 st050076 49.1 µM 0.78935762413851 0.236186748342224 no 819 0.214951507933509 1023 3895976 SGTC_1995 st072814 61.1 µM 0.788880813813463 0.236321236982979 no 820 0.215090835208605 1009 5769371 SGTC_3295 9122362 53.5725 µM 0.788814913396203 0.236339828104353 no 821 0.215110095889605 1030 4730473 SGTC_2034 5197015 53.07 µM 0.788774215450528 0.23635130977599 no 822 0.215121991157328 1035 780676 SGTC_1112 tnp00069 1.16933 µM 0.786413495152312 0.237017839565151 no 823 0.215812639926306 1091 145826 SGTC_3198 9112019 49.47 µM 0.784573653609601 0.237538019020102 no 824 0.216351791133223 1061 45595555 SGTC_424 splitomicin 100 mM 0.781762190559821 0.238334114424535 no 825 0.217177172570319 980 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1367 1812-0510 76.9 µM 0.780833152003438 0.238597502347898 no 826 0.217450316444569 1054 1142582 YDR527W RBA50 SGTC_419 nsc-638432 893 µM 0.780234993133173 0.238767168192799 no 827 0.217626284263222 1040 368090 SGTC_2190 6049624 200 µM 0.77882008409168 0.239168765189098 no 828 0.21804285253613 1025 2265554 SGTC_1790 st045711 43.5 µM 0.777983050202957 0.23940651617509 no 829 0.218289502828591 1085 585119 SGTC_995 3931-2021 34.6 µM 0.777974731243751 0.239408879738686 no 830 0.218291954997841 1024 730143 SGTC_3115 9123671 49.47 µM 0.777966980039952 0.239411082004388 no 831 0.218294239824819 1173 3286988 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.777826007591682 0.239451136911737 no 832 0.218335796761613 1063 4330530 SGTC_1516 st013856 110 µM 0.776457135928492 0.23984026858117 no 833 0.218739560136465 1015 5281404 A mutagen and neurotoxin. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.776162517603579 0.239924065365541 no 834 0.218826517132377 1085 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1437 4092-1038 11.6 µM 0.776158324253425 0.239925258173934 no 835 0.218827754948878 1101 3977136 SGTC_2354 9060492 162 µM 0.774630435111969 0.240360085066502 no 836 0.219279033880359 1107 6471895 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.774340808345968 0.240442559255863 no 837 0.219364638611892 1070 279621 SGTC_2929 9013348 24.6 µM 0.773278347554116 0.240745237785144 no 838 0.219678833612687 1050 2995952 SGTC_273 hydroxyurea 18.1 mM 0.773247972851861 0.240753894112331 no 839 0.219687819934373 1157 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_124 0136-0217 7.121 µM 0.772285084914948 0.241028390268518 no 840 0.219972798632325 1225 3976905 SGTC_540 1187-0821 17.3 µM 0.769472651931075 0.241831120761788 no 841 0.220806386766493 1041 847520 SGTC_2713 st079149 53.4 µM 0.768384866302091 0.242141987412691 no 842 0.221129284320987 1074 3103253 SGTC_3234 9132280 49.47 µM 0.768293064732317 0.242168232313999 no 843 0.221156546994092 1104 17612295 SGTC_417 st075190 100 µM 0.767936623071477 0.242270149068368 no 844 0.221262419102389 1100 222757 SGTC_2069 5228469 200 µM 0.766071539637276 0.242803808036001 no 845 0.221816868111716 1059 2835210 SGTC_1883 5-benzylidenerhodanine 20 µM 0.765579138577253 0.24294480552706 no 846 0.221963380616937 1097 1273210 SGTC_2350 9023895 38.85 µM 0.763882345534191 0.243431016000282 no 847 0.222468679532552 1069 2997209 SGTC_2705 st078069 42.8 µM 0.76369008121847 0.243486141849768 no 848 0.222525976508467 1042 1530061 SGTC_1142 3253-1408 9.78 µM 0.761493979227175 0.244116284376696 no 849 0.223181036830499 1088 256655 SGTC_1670 st016595 4.04 µM 0.761080056433272 0.244235152494005 no 850 0.22330462588315 1127 597879 SGTC_1607 st000305 50.6 µM 0.761057532665967 0.244241621643189 no 851 0.223311352145972 1078 5457690 SGTC_2189 6047310 154.431 µM 0.760349969801636 0.244444890874349 no 852 0.223522710032047 1073 711535 SGTC_508 roscovitine 141 µM 0.759641660021168 0.244648465939143 no 853 0.223734404951629 1116 160355 A CDKinase inhibitor. SGTC_1267 0828-0272 9.49 µM 0.757361439054747 0.245304443018717 no 854 0.224416675792794 1119 745334 SGTC_2382 9035899 200 µM 0.754748540248239 0.246057286236211 no 855 0.22519993783868 1133 6462679 SGTC_774 k060-0086 136 µM 0.754159687993404 0.246227120661821 no 856 0.225376670157872 1159 5911235 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.754023501043237 0.246266408107818 no 857 0.225417555146741 1078 4620898 SGTC_1808 st050063 61.5 µM 0.751249727527725 0.247067321873655 no 858 0.226251189051878 1102 4011993 SGTC_2263 7948595 193.29 µM 0.750992169235316 0.247141761228263 no 859 0.226328684267366 1026 2971371 SGTC_1146 3579-1023 7 µM 0.749325469848688 0.247623759595944 no 860 0.226830530028351 1147 X1146 SGTC_1004 4084-0029 199 µM 0.74861371138456 0.24782974829881 no 861 0.227045032733944 1121 716894 YLR208W SEC13 SGTC_72 0744-0168 198.391 µM 0.747669844348002 0.248103052137163 no 862 0.227329662336736 1052 677577 SGTC_2038 4100038 30.985 µM 0.745530826782754 0.248723015400757 no 863 0.227975441293369 1086 3596803 SGTC_1626 st003712 1.76 µM 0.74495232945885 0.248890826086419 no 864 0.228150269335844 1070 24207035 SGTC_2437 5741531 144.16 µM 0.744652631893072 0.24897778614192 no 865 0.228240870761588 1170 2262990 SGTC_3277 9138724 49.47 µM 0.744130251192395 0.249129398437301 no 866 0.228398839757649 1002 15943418 SGTC_1457 k015-0032 57.3 µM 0.742977427239123 0.249464160079368 no 867 0.228747673389487 1082 4302660 SGTC_611 3453-1652 23.7 µM 0.742058806401664 0.249731083919785 no 868 0.229025853373771 1137 1560575 SGTC_2417 cerulenin 830 nM 0.740290073797346 0.250245451742402 no 869 0.229562001329105 1123 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3189 9110682 49.47 µM 0.740105383075763 0.250299194307345 no 870 0.229618026315589 1145 17122418 SGTC_1774 st048371 48.465 µM 0.739762288359652 0.250399046586455 no 871 0.229722122671908 1130 4242727 SGTC_841 0251-0215 91.2 µM 0.739223629413246 0.250555857321133 no 872 0.229885607331587 1150 3888614 SGTC_791 1348-1292 225 µM 0.738801550893203 0.250678766300301 no 873 0.230013754969752 1157 5437054 SGTC_3046 9092212 49.47 µM 0.738744276778536 0.250695446943894 no 874 0.230031147094938 1143 25236637 SGTC_3355 9151058 44.0485 µM 0.738606981046359 0.250735435659048 no 875 0.23007284195463 1156 17015728 SGTC_3035 9091303 49.47 µM 0.736321281217461 0.251401663826724 no 876 0.230767599009027 1157 25237002 SGTC_2355 9061122 103.12 µM 0.736260889852303 0.25141927917914 no 877 0.230785971331508 1131 5302957 SGTC_2552 juarezic acid 87.02 µM 0.735621809944753 0.251605730200798 no 878 0.23098044292845 1225 1549512 SGTC_1290 0986-0249 10.2 µM 0.735192204850691 0.251731108164488 no 879 0.231111222877273 1120 53329 SGTC_2610 ononetin 44.17 µM 0.734404897097328 0.251960965354421 no 880 0.231351001530087 1127 259632 SGTC_276 colchicine 750 µM 0.733901928026329 0.252107866855089 no 881 0.231504255966689 1184 2833 A microtubule depolymerizer. SGTC_2566 crystal violet carbinol 226 nM 0.729020938196841 0.253535794370361 no 882 0.232994427333137 1099 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_950 1165-0508 94.1 µM 0.728716382887411 0.253625032272972 no 883 0.233087584628614 1121 6148369 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.728221274839987 0.253770139330742 no 884 0.233239072272189 1130 75037 A free radical scavenger. SGTC_2297 7971671 152.32 µM 0.727275147931674 0.25404755290429 no 885 0.233528709566891 1142 909016 SGTC_3329 9141233 27.5565 µM 0.72713908323868 0.254087461471306 no 886 0.233570379374498 1139 4909101 YNL103W MET4 SGTC_828 2074-0507 139 µM 0.726708197716126 0.254213864398565 no 887 0.233702365250847 1169 X828 SGTC_2075 5212009 200 µM 0.725241482582799 0.254644381363094 no 888 0.234151949051016 1074 780898 SGTC_464 bw-b 70c 158 µM 0.725218173854426 0.254651226129129 no 889 0.234159097605839 1177 5353454 SGTC_265 mycophenolic acid 32.932 µM 0.724400551644172 0.254891387389665 no 890 0.234409930644122 1233 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_48 0382-0018 55 µM 0.724382059459634 0.254896820494137 no 891 0.234415605460863 1251 762596 SGTC_649 1123-0311 367 µM 0.721678627511873 0.255691755156978 no 892 0.235246042586268 1146 693629 YIL048W NEO1 SGTC_2719 novobiocin 32.65 µM 0.719021732509688 0.256474265205148 no 893 0.236063764697789 1148 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_554 4483-2211 187 µM 0.717216212083083 0.257006739115779 no 894 0.236620348710759 1126 747107 SGTC_2396 5342950 42.78 µM 0.715222707881341 0.257595319433919 no 895 0.237235719812484 1158 1886677 SGTC_667 1498-1044 59 µM 0.71487680151286 0.257697519198206 no 896 0.237342586432569 1177 6739982 SGTC_2993 9054257 71.4286 µM 0.713238346381196 0.258181894795584 no 897 0.237849140662782 1195 6470217 YGL055W OLE1 SGTC_2337 9009472 200 µM 0.711241870812382 0.25877274911165 no 898 0.238467183078061 1180 5742383 SGTC_1335 1486-0900 202 µM 0.710017894713479 0.259135328942552 no 899 0.238846519685276 1192 X1335 SGTC_465 cgp-37157 41 µM 0.709702630046249 0.259228762672968 no 900 0.238944280435365 1081 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1203 3992-3522 103 µM 0.709566374631182 0.25926914953434 no 901 0.238986538790094 1262 5322312 SGTC_2540 epiandrosterone 100 µM 0.709537198517735 0.259277797918986 no 902 0.238995588022524 1265 441302 A steroid. SGTC_763 3453-1109 128 µM 0.709177833435403 0.259384333155559 no 903 0.239107063678562 1196 1560353 SGTC_906 1165-0455 526 µM 0.705851355719212 0.260371553386193 no 904 0.240140290547095 1172 3252859 SGTC_3221 9128209 49.47 µM 0.702856796998013 0.261261920433981 no 905 0.241072498679028 1188 16460723 SGTC_1038 k292-0204 154 µM 0.70213854635766 0.261475709032576 no 906 0.241296382789935 1159 4454212 SGTC_2423 st077119 87.2 µM 0.702043575200252 0.261503984091119 no 907 0.241325994466944 1167 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_68 0986-0284 82.829 µM 0.701591249389212 0.261638673240471 no 908 0.241467055176709 1142 423278 YIL048W NEO1 SGTC_743 1275-0778 158 µM 0.701446468713139 0.261681792132329 no 909 0.241512215420157 1183 2849257 YMR203W TOM40 SGTC_2834 9001755 58.44 µM 0.699439686763432 0.262279831566196 no 910 0.242138646541781 1100 2989575 SGTC_2662 daunorubicin 22.37 µM 0.69572880890959 0.263387548501807 no 911 0.243299340130488 1166 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1993 st073995 70.8 µM 0.694668871182166 0.263704383577159 no 912 0.243631420217802 1194 3098394 SGTC_1170 0310-0127 64.8 µM 0.694656632419332 0.263708043105683 no 913 0.243635256069493 1185 774975 SGTC_2727 riluzole 51.77 µM 0.693570363376136 0.264032952982551 no 914 0.243975842482095 1201 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2320 7373003 200 µM 0.688649588298552 0.265507338242976 no 915 0.245521903619015 1213 5415828 SGTC_2977 9011197 71.43 µM 0.687426268453396 0.265874522141282 no 916 0.245907074454761 1197 2704722 SGTC_3206 9114350 49.47 µM 0.686387918592025 0.266186388406551 no 917 0.246234260457789 1150 17087243 SGTC_2591 skatole 100 µM 0.685584219026662 0.266427905021382 no 918 0.246487667873847 1223 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2988 9073640 71.4286 µM 0.685167752938306 0.266553099210498 no 919 0.246619035063896 1236 9102229 SGTC_1880 MG-132 525 µM 0.682574291675252 0.267333390475201 no 920 0.247437941788137 1159 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2168 5727979 200 µM 0.681667387959061 0.267606521094518 no 921 0.247724646645924 1161 695210 SGTC_2048 5246248 200 µM 0.676734890078299 0.269094491792359 no 922 0.249287087668488 1222 677046 SGTC_1396 3511-0007 98.6 µM 0.674126817262014 0.269882935256633 no 923 0.250115345698793 1187 X1396 SGTC_863 0466-0191 129 µM 0.671936159237148 0.270546082972362 no 924 0.250812169728663 1240 765160 YPR165W RHO1 SGTC_1795 st049545 62.3 µM 0.671470159631034 0.270687253537714 no 925 0.25096053149874 1192 5291882 SGTC_926 2268-1401 59.4 µM 0.669344767927436 0.271331588747177 no 926 0.251637787725362 1232 2931578 SGTC_343 4130-2827 29.8 µM 0.668562741758979 0.271568860550199 no 927 0.251887223157616 1256 1118244 SGTC_115 0527-0192 112.043 µM 0.666323902605758 0.272248709667912 no 928 0.252602045351704 1266 4233931 SGTC_3172 9105863 49.47 µM 0.665820224069955 0.272401773873185 no 929 0.252763008219395 1223 2348785 SGTC_1373 2887-0003 58.5 µM 0.664707734338909 0.272740002720908 no 930 0.253118722967577 1233 776948 SGTC_488 nitrendipine 139 µM 0.664600933367823 0.272772484244254 no 931 0.253152886056632 1280 4507 Dihydropyridine L-type calcium channel blocker. SGTC_303 1348-1668 34.2 µM 0.664502341495245 0.272802470826863 no 932 0.253184425402992 1253 5380509 SGTC_2471 5466956 24.79 µM 0.663777663824044 0.273022930717267 no 933 0.253416311768434 1212 724419 SGTC_1129 3453-1384 223 µM 0.661816689117052 0.273619936742631 no 934 0.254044354530421 1321 1084452 SGTC_741 4582-0002 126 µM 0.661705768942744 0.273653724961869 no 935 0.254079903397829 1235 2912688 SGTC_1669 st015249 58.4 µM 0.661202959590545 0.273806915341248 no 936 0.254241081761336 1316 722793 SGTC_1761 st044296 37 µM 0.661099532004507 0.273838431769499 no 937 0.254274242702012 1253 1826700 SGTC_1853 st056710 91.2 µM 0.658758101519619 0.274552391456352 no 938 0.255025558191557 1336 269167 SGTC_1210 3013-0140 750 nM 0.658574607499519 0.274608382072743 no 939 0.255084486574707 1272 905973 SGTC_2448 5185112 27.17 µM 0.657989845713351 0.274786851463375 no 940 0.255272328028278 1244 5718189 SGTC_1302 1159-0335 255 µM 0.657059748533364 0.275070835023131 no 941 0.255571249556706 1260 649284 SGTC_2731 amoxapine 43.43 µM 0.656543401548165 0.275228551952373 no 942 0.255737275871295 1290 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1911 st060208 74.3 µM 0.654605159393992 0.275820980198558 no 943 0.256361000701658 1279 688783 SGTC_2714 st079313 56.9 µM 0.652913619777849 0.276338514757288 no 944 0.256905983993737 1259 2939799 SGTC_1107 amlodipine 47 µM 0.650767103039451 0.27699593675775 no 945 0.257598419508075 1163 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_3326 9140064 16.379 µM 0.650636740666322 0.277035887995201 no 946 0.257640503735671 1247 1868434 SGTC_3286 9117135 37.221 µM 0.650507890075152 0.277075378698813 no 947 0.257682103430141 1223 3438150 SGTC_1714 st033236 13.627 µM 0.648410648284334 0.277718537784557 no 948 0.258359692503108 1320 2916566 SGTC_2222 6885208 172.143 µM 0.647542178353128 0.277985083927634 no 949 0.2586405528883 1239 609514 SGTC_1859 st055998 20 µM 0.644445871263478 0.278936400586626 no 950 0.259643173550206 1305 676301 SGTC_2543 pimpinellin 60.67 µM 0.644093637070599 0.279044722097503 no 951 0.259757358098111 1220 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_3347 9188721 44.724 µM 0.641921088391447 0.27971329122452 no 952 0.260462210471222 1264 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_626 0214-0009 33 µM 0.638232049813667 0.280850314672043 no 953 0.261661318535899 1340 3437874 SGTC_2081 5214970 32.255 µM 0.636871736533236 0.281270149174808 no 954 0.262104197059012 1258 2063512 SGTC_1508 1080-0625 72.9 µM 0.636870610153089 0.281270496935866 no 955 0.262104563934816 1232 767111 SGTC_2678 equilin 100 µM 0.636807364008368 0.281290024021317 no 956 0.262125164400708 1319 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1526 st051518 75 µM 0.636439738927743 0.28140354028104 no 957 0.262244923270944 1291 673993 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.634854112396547 0.281893407448466 no 958 0.262761783657833 1337 688788 SGTC_1597 7-benzyloxygramine 47.5 µM 0.634177493892902 0.282102568547445 no 959 0.262982496810592 1276 260807 SGTC_2245 6637752 200 µM 0.633538986377984 0.282300017010093 no 960 0.263190865023162 1265 681890 SGTC_2808 7946468 45.46 µM 0.633533832041761 0.282301611178475 no 961 0.263192547413532 1308 2970879 SGTC_1540 guanosine 70.6 µM 0.632717530148326 0.28255413726324 no 962 0.263459060045001 1246 6802 Guanosine is a purine nucleoside SGTC_2353 9059630 146.67 µM 0.632198720315528 0.282714689475382 no 963 0.263628516709118 1305 4779114 SGTC_2665 lovastatin 100 µM 0.631717747254225 0.282863571769543 no 964 0.263785664564989 1282 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1999 st074831 12.5 µM 0.630699225288906 0.283178973306742 no 965 0.264118602857821 1286 17112523 SGTC_3013 9080133 71.4286 µM 0.630391991978015 0.283274146104266 no 966 0.264219074448872 1373 17050193 SGTC_1955 wogonin 32.4 µM 0.630087173542897 0.28336858599482 no 967 0.264318775558171 1366 5281703 A flavanone. SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.629962655632519 0.283407168902255 no 968 0.264359508833494 1262 140250 A respiratory chain inhibitor. SGTC_2224 6650123 117.647 µM 0.628940756955172 0.283723907793696 no 969 0.264693921025387 1260 2908370 SGTC_1623 st003709 20.3 µM 0.628823767132688 0.283760179761029 no 970 0.26473221918949 1289 16192618 SGTC_893 0958-0369 48.9 µM 0.628339532005522 0.283910337463656 no 971 0.264890769919376 1327 6819948 SGTC_462 ag-879 158 µM 0.627939822289374 0.284034313110734 no 972 0.265021681260633 1298 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2823 7987624 58.44 µM 0.627301755722442 0.284232272174975 no 973 0.26523072638692 1328 2239440 SGTC_2139 5578692 56.4705 µM 0.627258837133095 0.284245589961371 no 974 0.265244790497897 1267 650991 YMR113W FOL3 SGTC_2849 9019321 12.99 µM 0.626505663203334 0.284479350970486 no 975 0.265491661750992 1293 16489627 SGTC_2516 gossypol 71.55 µM 0.625947210443697 0.284652736047247 no 976 0.265674783589296 1323 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2658 polymyxin b sulfate 77.05 µM 0.624861921588876 0.284989834267238 no 977 0.266030842948931 1273 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_761 k216-0224 480 µM 0.624575814875703 0.285078732687965 no 978 0.266124748499576 1349 1340404 SGTC_2095 5432005 200 µM 0.624096913331523 0.28522756545321 no 979 0.266281970456442 1308 783734 SGTC_2634 4'-methoxyflavone 100 µM 0.623442143652167 0.285431114319529 no 980 0.266497005451538 1308 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2644 guaiazulene 100 µM 0.623012779764544 0.285564628614453 no 981 0.266638061879675 1312 3515 A coloring agent. SGTC_403 arphamenine a 50 µM 0.622990363899634 0.285571599831646 no 982 0.266645427070437 1263 5487158 An arginine aminopeptidase inhibitor. SGTC_180 1486-1293 102.781 µM 0.622297129058146 0.28578723223144 no 983 0.266873254317948 1370 4140536 SGTC_1073 triclabendazole 3.09 µM 0.6204426331977 0.286364458077666 no 984 0.267483205716201 1344 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1498 4478-3555 97.6 µM 0.617554112242446 0.287264632749409 no 985 0.268434650476391 1297 3437919 SGTC_678 1218-2179 85.9 µM 0.614200516038133 0.288311419618323 no 986 0.269541416208009 1331 6820081 YOR116C RPO31 SGTC_2044 5102272 200 µM 0.614056582987694 0.288356386908542 no 987 0.26958896863329 1301 592666 SGTC_1300 1094-0077 113 µM 0.613773001201089 0.288444992665823 no 988 0.269682670334893 1284 5532636 SGTC_1420 4'-methoxyflavone 42 µM 0.61363994858956 0.288486569671504 no 989 0.269726639485836 1333 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_537 1334-0398 209 µM 0.613357981566895 0.288574689598027 no 990 0.269819831412843 1301 5846986 SGTC_3309 9129340 25.759 µM 0.612849367909519 0.288733672863191 no 991 0.269987972277401 1365 17158987 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.612138474797328 0.288955954044466 no 992 0.270223071849584 1322 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1646 st011709 75.6 µM 0.611529057834833 0.289146569860859 no 993 0.270424693692721 1304 5757843 SGTC_1499 4480-0877 67.3 µM 0.608051679945895 0.290235367290336 no 994 0.271576599198755 1279 2861909 SGTC_2094 5332512 191.667 µM 0.607544213329501 0.290394419979156 no 995 0.271744905108732 1397 755774 SGTC_1202 1988-0068 29.6 µM 0.6073316499903 0.290461054753585 no 996 0.271815419093523 1272 2850480 SGTC_2695 st077686 51.995 µM 0.606585846669417 0.290694907238617 no 997 0.272062897643523 1299 2876092 SGTC_3078 9116413 49.47 µM 0.60550399068263 0.291034288101231 no 998 0.272422086950027 1268 17177322 SGTC_3088 9117578 49.47 µM 0.605494739214607 0.291037191107347 no 999 0.272425159564965 1376 678341 SGTC_1081 sertraline 6 µM 0.60454023969643 0.29133677493614 no 1000 0.272742262202705 1337 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1169 aniline yellow 25.8 µM 0.604275323462811 0.291419948331085 no 1001 0.272830304800058 1327 6051 A DNA damaging agent. SGTC_506 n9-isopropylolomoucine 153 µM 0.603473616679031 0.291671720547754 no 1002 0.273096830905845 1361 6610355 SGTC_1985 st071382 65.5 µM 0.600293123644944 0.292671536895097 no 1003 0.274155450330128 1353 6123237 SGTC_2424 5537928 59.2 µM 0.599038711261932 0.293066309900491 no 1004 0.274573535153949 1351 5382802 SGTC_2496 diffractaic acid 79.83 µM 0.597665779263132 0.293498664808932 no 1005 0.275031481756387 1438 94870 An apoptosis inducer which activates caspases. SGTC_1282 0886-0010 32.4 µM 0.595388823380266 0.294216359592978 no 1006 0.275791797354528 1400 2836211 YNL267W PIK1 SGTC_1617 st002906 78 µM 0.594637649214437 0.294453306857313 no 1007 0.276042854004983 1351 5150859 SGTC_2605 digitonin 300 nM 0.593705003631424 0.294747619224163 no 1008 0.276354717919519 1400 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_484 loperamide 105 µM 0.593485969775531 0.294816758791666 no 1009 0.276427984895538 1333 3955 An opioid-receptor agonist. SGTC_736 0958-0254 92.6 µM 0.592213662978459 0.295218519092255 no 1010 0.276853760679145 1393 6812352 SGTC_2194 5927483 104.545 µM 0.591350612879363 0.295491190509755 no 1011 0.277142761965424 1359 760979 SGTC_1587 estradiol valerate 56.1 µM 0.590630606498418 0.295718757378827 no 1012 0.277383976464853 1351 13791 A steroid. SGTC_341 1486-1430 230 µM 0.590559480842582 0.295741241886866 no 1013 0.277407810350319 1309 2054753 YPL210C SRP72 SGTC_590 k048-0076 22.4 µM 0.588924010300188 0.296258469493683 no 1014 0.277956125145792 1416 6832814 SGTC_1408 3909-7976 48.8 µM 0.588493028141863 0.296394839287476 no 1015 0.278100706057678 1374 24152374 SGTC_1824 st053723 68.6 µM 0.588440783996767 0.296411372143578 no 1016 0.278118234812163 1319 675225 SGTC_2377 9073351 62.6 µM 0.587206529450469 0.296802079531554 no 1017 0.27853250382826 1329 7337946 YHR072W ERG7 SGTC_1782 st039423 80.636 µM 0.585179535346606 0.297444242214656 no 1018 0.279213501887623 1323 2068169 SGTC_1217 1183-1422 255 µM 0.584455305884322 0.297673835777089 no 1019 0.279457013352163 1405 2849664 SGTC_908 3448-7491 47.7 µM 0.583608682294643 0.297942332918806 no 1020 0.279741808731103 1361 1203031 SGTC_1875 nocodazole 6 µM 0.583280428496747 0.298046464608573 no 1021 0.279852267770989 1362 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_404 fumagillin 50 µM 0.583182595703104 0.298077503235202 no 1022 0.279885193085579 1371 12015870 A methionine aminopeptidase binder. SGTC_2167 5876490 200 µM 0.583073516739467 0.298112111580478 no 1023 0.279921905477716 1539 686534 SGTC_2338 7999974 200 µM 0.580319989091974 0.298986350744351 no 1024 0.280849425007943 1408 315925 SGTC_2895 9054447 58.44 µM 0.580163394313515 0.299036104225927 no 1025 0.280902218223835 1376 2697450 SGTC_2495 cafestol 54.53 µM 0.580032132502279 0.299077811782708 no 1026 0.280946474564212 1381 16667697 An anti-infammatory. SGTC_1904 st060225 78 µM 0.578297893237164 0.29962910239228 no 1027 0.281531508268515 1333 66595 SGTC_214 4373-3496 70 µM 0.5766027147604 0.300168420660267 no 1028 0.28210393243736 1428 3779166 SGTC_232 clozapine 119 µM 0.575871933868153 0.300401052736976 no 1029 0.28235087367469 1365 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1524 corynanthine 62.1 µM 0.574022283199183 0.300990222277208 no 1030 0.282976361180648 1431 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2304 7443016 91.4 µM 0.573300246487741 0.301220354038792 no 1031 0.283220709272181 1356 939854 SGTC_1068 loratadine 26.9 µM 0.572735125075519 0.301400528112112 no 1032 0.28341202544618 1367 3957 A H1 histamine antagonist. SGTC_1072 oxiconazole 14.9 nM 0.571852027229656 0.301682177685305 no 1033 0.283711113337612 1386 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1308 1187-1617 41.4 µM 0.571756864499324 0.301712535340003 no 1034 0.2837433521049 1373 2882570 SGTC_1527 coumarin 137 µM 0.57134169710232 0.301844993048771 no 1035 0.283884021015439 1430 323 A hepatotoxic, DNA x-linker. SGTC_2394 5221648 200 µM 0.570208142749819 0.302206782623229 no 1036 0.284268266966813 1514 788586 SGTC_852 0418-0143 439 µM 0.569855195247156 0.302319470427714 no 1037 0.284387957885172 1396 5369229 SGTC_3228 9131799 49.47 µM 0.569677446097796 0.302376228670734 no 1038 0.284448244971209 1415 17015818 SGTC_1268 0828-0275 2.46 µM 0.568600850130008 0.302720105659141 no 1039 0.284813523885308 1428 745337 SGTC_3202 9113761 49.47 µM 0.568103632803383 0.302878981638254 no 1040 0.284982300584059 1523 4798415 SGTC_2725 haloperidol 53.21 µM 0.568010114665569 0.30290886768294 no 1041 0.285014049943989 1344 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_201 4262-0159 12.803 µM 0.567931284255445 0.30293406092458 no 1042 0.285040814137913 1372 1341029 SGTC_2317 5986382 200 µM 0.567832886396705 0.302965509001024 no 1043 0.28507422347713 1469 877883 SGTC_1959 st077091 55.8 µM 0.567293524817623 0.303137915571589 no 1044 0.285257387791292 1379 821356 YKL052C ASK1 SGTC_1657 st012939 43.4 µM 0.566466114171519 0.303402482087057 no 1045 0.285538480967822 1428 24207257 SGTC_985 1493-0307 8.71 µM 0.566009966390643 0.303548380523831 no 1046 0.285693502734874 1379 3278274 SGTC_2621 lithochol-11-enic acid 100 µM 0.564807136288405 0.303933254742547 no 1047 0.286102476286673 1435 6708711 SGTC_879 0831-1030 162 µM 0.563840120865649 0.304242832123696 no 1048 0.286431472192291 1388 1549252 SGTC_2587 piperic acid 92.2 µM 0.562424529303696 0.304696268400856 no 1049 0.286913405235403 1363 5370536 SGTC_2686 alizarin 95.37 µM 0.562366216893413 0.304714953226951 no 1050 0.286933265721389 1358 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_731 3966-0296 387 µM 0.562178826242599 0.304775001556477 no 1051 0.286997093069429 1411 660956 SGTC_847 0342-0274 5.54 µM 0.561650610682677 0.304944293704717 no 1052 0.287177045374013 1425 18097 SGTC_814 3342-0569 96 µM 0.561524972848871 0.304984566556056 no 1053 0.287219855491977 1426 4346283 SGTC_1043 0916-0009 19.3 µM 0.560751377538513 0.305232592375395 no 1054 0.2874835186326 1468 3101130 SGTC_36 0335-0881 14.2 µM 0.558835178718394 0.305847338436393 no 1055 0.288137105745407 1368 23828853 SGTC_18 0111-0177 500 nM 0.558469889293287 0.305964591082781 no 1056 0.288261780093299 1428 721752 SGTC_496 calpeptin 138 µM 0.557414571412259 0.30630344461546 no 1057 0.288622106021577 1347 73364 A calpain inhibitor. SGTC_3067 9117431 49.47 µM 0.557282191978263 0.306345962222756 no 1058 0.288667320400594 1399 17150885 SGTC_2784 7567673 72.73 µM 0.556774753329968 0.306508965445671 no 1059 0.288840667668817 1402 3471247 SGTC_2032 5185112 25.99 µM 0.556305322637513 0.306659793565822 no 1060 0.289001074570324 1350 5718189 SGTC_2478 5763493 32.33 µM 0.55380964490328 0.307462204373165 no 1061 0.289854563430617 1416 1365576 YLR208W SEC13 SGTC_2818 7996756 12.99 µM 0.553722594636712 0.307490209459777 no 1062 0.289884354800113 1378 2241621 SGTC_233 rapamycin 362 pM 0.549815042813366 0.308748468250834 no 1063 0.291223119944943 1437 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2854 9024559 71.43 µM 0.548183525071793 0.3092744945569 no 1064 0.291782946645641 1368 3163529 SGTC_2779 methotrexate 400 µM 0.546040369690129 0.309966075003038 no 1065 0.292519093839708 1435 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2723 salbutamol 83.58 µM 0.545924358731012 0.310003530104856 no 1066 0.29255896677408 1438 9884233 β2-adrenoceptor agonist SGTC_2774 tamoxifen 10.92 µM 0.544818795493117 0.310360569266923 no 1067 0.29293907520407 1439 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1688 st021091 57.6 µM 0.542034308857372 0.311260604603754 no 1068 0.293897435533338 1455 3656366 SGTC_1763 st044482 94.5 µM 0.541090405311055 0.311565961108614 no 1069 0.294222635583743 1458 88505 SGTC_857 0438-0306 1.35 µM 0.539422869994247 0.312105732070678 no 1070 0.29479755203297 1441 4686136 SGTC_2096 5468907 200 µM 0.536938724382406 0.312910583120962 no 1071 0.295654970472402 1488 759785 SGTC_25 0118-0223 35.662 µM 0.536317819460286 0.313111892859517 no 1072 0.295869458617661 1474 5333628 SGTC_2290 7904846 200 µM 0.534874539830756 0.313580048066752 no 1073 0.296368307442957 1416 2962154 SGTC_2690 usnic acid 100 µM 0.532587345284526 0.314322558215837 no 1074 0.297159632009494 1576 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_687 k029-0044 34.9 µM 0.531795115453123 0.314579921569983 no 1075 0.297433953087008 1515 5829338 SGTC_1716 st033144 30.6155 µM 0.530226830046853 0.315089659608923 no 1076 0.297977335466614 1503 674617 SGTC_2900 5328528 85.29 µM 0.529476146323148 0.315333778244027 no 1077 0.298237593759743 1398 795359 SGTC_1745 st081495 74 µM 0.528855579428147 0.315535644423525 no 1078 0.298452819322457 1429 13842402 YBL026W LSM2 SGTC_1765 st044815 90.4 µM 0.527786788310447 0.315883443938149 no 1079 0.298823663989618 1371 645695 SGTC_1486 3970-0793 4.53 µM 0.526789595467864 0.316208091433414 no 1080 0.299169854486418 1486 2844330 SGTC_1206 3978-0017 132 µM 0.526651775367667 0.316252971491589 no 1081 0.299217715120877 1504 3873677 SGTC_2884 9058502 51.95 µM 0.525883595920654 0.316503172812896 no 1082 0.299484543578567 1419 6471554 SGTC_627 1391-0720 175 µM 0.525672792089775 0.316571847761502 no 1083 0.299557785510704 1422 997839 SGTC_2342 7990637 118.86 µM 0.524701862135084 0.316888235601928 no 1084 0.29989523130991 1484 2033102 YER133W GLC7 SGTC_1981 st071826 47 µM 0.524192107389261 0.317054398243343 no 1085 0.300072464949273 1410 11838600 SGTC_376 3970-0862 59.1 µM 0.523670041207476 0.317224612238069 no 1086 0.300254028173904 1524 3135186 SGTC_2775 cyproheptadine 69.59 µM 0.523060769134898 0.317423307663207 no 1087 0.300465982477602 1449 2913 A selective serotonin reuptake inhibitor. SGTC_1631 benzylvanillin 81.9 µM 0.522728904047955 0.317531557437602 no 1088 0.300581460528928 1479 75506 SGTC_2130 NSC 7 2.4545 µM 0.522652564399117 0.317556460576956 no 1089 0.300608027031281 1511 21448 SGTC_2863 9028737 58.44 µM 0.520975288744467 0.31810382125731 no 1090 0.30119199294634 1519 6460917 SGTC_2261 9010538 184.68 µM 0.519310610568306 0.318647463983926 no 1091 0.301772077650581 1375 6457250 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.518928456796717 0.318772321122251 no 1092 0.301905316314848 1420 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.517505341756183 0.319237461615607 no 1093 0.302401720491019 1439 688664 SGTC_94 0334-0113 514.748 µM 0.51355046392831 0.320531593580429 no 1094 0.30378316015366 1401 6795178 SGTC_1127 asiatic acid 681.4 nM 0.512694008475985 0.320812134934349 no 1095 0.304082690739322 1435 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1618 st003135 44.5 µM 0.510659737896155 0.321478892580479 no 1096 0.304794668961722 1449 1270615 SGTC_1838 st055369 84.5 µM 0.510220142686909 0.321623051116509 no 1097 0.304948621031537 1429 676036 SGTC_999 SEC7.066 22.7 µM 0.509467481735726 0.321869937145772 no 1098 0.305212293044408 1526 740511 YDR170C SEC7 SGTC_946 3434-1334 87.4 µM 0.509086680228369 0.321994876709466 no 1099 0.305345733873394 1535 4047976 SGTC_1056 3448-1962 115 µM 0.507990185610808 0.322354744883161 no 1100 0.305730113017485 1508 715507 SGTC_1389 3405-0187 19 µM 0.507017642146237 0.322674071832125 no 1101 0.306071219977685 1425 799890 SGTC_2188 6126565 140.678 µM 0.50657292703411 0.322820134122232 no 1102 0.30622725408346 1494 874518 SGTC_713 1488-1073 324 µM 0.503011515332837 0.323990829114304 no 1103 0.307478088036452 1475 3312542 SGTC_1709 st033179 39.1045 µM 0.502668027524467 0.324103831581935 no 1104 0.307598846111442 1473 573381 SGTC_394 menadione 8.33 µM 0.502394883005741 0.32419370370523 no 1105 0.307694888876386 1472 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2262 9014885 67.46 µM 0.500816661183104 0.324713182935497 no 1106 0.308250079364877 1464 6457424 SGTC_2016 5121758 140 µM 0.500347587090529 0.324867646715895 no 1107 0.308415175999079 1435 2795203 SGTC_1903 st060211 78.3 µM 0.500230678531518 0.3249061488157 no 1108 0.308456329497527 1564 688960 SGTC_2122 5258151 111.688 µM 0.499263184587839 0.325224850347989 no 1109 0.308796993651023 1436 2173356 SGTC_2493 resveratrol 26.09 µM 0.498614417706408 0.325438631859054 no 1110 0.309025523068923 1441 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_258 haloperidol 50.781 µM 0.498575762682146 0.325451371267632 no 1111 0.309039141712363 1423 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_81 0411-0046 9.971 µM 0.497003796577311 0.325969611573705 no 1112 0.309593187020998 1413 12925265 SGTC_2017 5132927 60.65 µM 0.495426961486939 0.326489795036457 no 1113 0.310149383464371 1444 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_781 4335-2806 94.4 µM 0.492006718291718 0.327619261198184 no 1114 0.31135729709297 1624 845254 SGTC_2193 5925765 200 µM 0.490029986476534 0.328272757770395 no 1115 0.312056339908992 1537 877370 SGTC_2243 6634756 200 µM 0.489711470618903 0.328378106589889 no 1116 0.312169041896975 1592 885676 SGTC_2270 7924575 90.91 µM 0.48926930086493 0.328524376441037 no 1117 0.312325526075447 1625 1262135 SGTC_2321 7390090 138.78 µM 0.489020208444264 0.328606787842606 no 1118 0.312413694964085 1431 649046 SGTC_866 0495-0101 262 µM 0.488419417407495 0.328805591863387 no 1119 0.312626395471775 1433 635694 SGTC_2595 hexamethylquercetagetin 100 µM 0.487503603398715 0.32910873137986 no 1120 0.312950744933214 1510 386331 SGTC_747 3448-8087 38.7 µM 0.485226329803062 0.329863008510693 no 1121 0.313757903450221 1486 5168703 SGTC_686 1319-0111 510 µM 0.484900571813851 0.329970962540032 no 1122 0.313873438382597 1584 4562600 SGTC_1091 telmisartan 47.6 µM 0.484621522334126 0.330063448941788 no 1123 0.313972421958927 1581 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_623 k072-0108 16.9 µM 0.484614434688936 0.330065798161541 no 1124 0.31397493624106 1514 5382803 SGTC_3134 9127454 49.47 µM 0.483297719194159 0.330502343347816 no 1125 0.314442179641721 1559 24262820 SGTC_796 1234-0020 70.7 µM 0.482888409495165 0.330638093336144 no 1126 0.314587485964765 1458 46495034 SGTC_146 3448-8650 53.125 µM 0.481784122478481 0.33100444777905 no 1127 0.314979654805411 1535 2891488 YIL048W NEO1 SGTC_443 clozapine 122 µM 0.48026791441215 0.331507723388149 no 1128 0.315518450353395 1503 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_155 k072-0202 43.6 µM 0.479375363550343 0.331804130574433 no 1129 0.315835808373859 1461 5857737 SGTC_236 1509-0011 5.31 µM 0.478531760608092 0.332084379468401 no 1130 0.316135887178699 1532 3107280 SGTC_3276 9139060 49.47 µM 0.478476731728287 0.332102663588635 no 1131 0.316155465765222 1535 4870619 SGTC_280 3448-3607 3.04 µM 0.478367472542035 0.332138967676573 no 1132 0.316194340343708 1523 626179 SGTC_2472 5377652 49.4 µM 0.477985948188345 0.332265751007195 no 1133 0.316330103200587 1481 1610903 SGTC_1775 st081588 35.1725 µM 0.473144313106647 0.333876325189611 no 1134 0.318055111919132 1508 1426443 YGL099W LSG1 SGTC_141 0443-0274 32.331 µM 0.471932237770342 0.334280003993204 no 1135 0.318487578274261 1580 1627241 SGTC_246 cycloheximide 667 µM 0.471568453571162 0.334401198884782 no 1136 0.318617424140229 1471 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_989 1501-0895 10.3 µM 0.471541019772129 0.334410339169036 no 1137 0.318627217017638 1578 2830112 SGTC_709 3807-1509 243 µM 0.470452544801021 0.334773072103708 no 1138 0.319015865515402 1555 1886677 YPL242C IQG1 SGTC_2308 7584454 197.62 µM 0.469409057664216 0.335120957710307 no 1139 0.319388637656774 1620 893577 SGTC_2445 5742597 35.57 µM 0.469344250542074 0.335142568266508 no 1140 0.319411795181083 1479 1774255 SGTC_708 3448-5400 146 µM 0.467541153946402 0.335744046693361 no 1141 0.32005637771638 1507 3462195 SGTC_2024 5144227 134 µM 0.465258692080733 0.33650603588945 no 1142 0.320873106242211 1590 3475211 SGTC_74 000s-0487 160.283 µM 0.463989933902116 0.336929895635028 no 1143 0.321327478778947 1420 677548 SGTC_189 3970-0742 2.116 µM 0.463569065881992 0.33707054268922 no 1144 0.321478260772438 1577 2891807 SGTC_65 0798-0905 34.986 µM 0.462731147479742 0.337350628813524 no 1145 0.321778544611295 1731 3602145 SGTC_345 1362-0200 395 µM 0.462542710462414 0.337413628984794 no 1146 0.321846090609933 1486 1419823 SGTC_703 3875-0075 71.8 µM 0.461878388872517 0.337635768054246 no 1147 0.322084266279918 1594 2850814 SGTC_613 3914-0030 117 µM 0.461110544886473 0.337892593936904 no 1148 0.322359648340679 1474 1145395 SGTC_522 1273-0010 11.6 µM 0.460965083017442 0.337941256043413 no 1149 0.322411828248696 1578 5705015 SGTC_2656 pseudo-anisatin 100 µM 0.460876553992623 0.337970873438839 no 1150 0.322443586987594 1560 6708809 A neurotoxin. SGTC_84 0443-0269 128.823 µM 0.458065125930832 0.338911957888585 no 1151 0.323452826452231 1503 6150058 SGTC_2827 7993847 71.43 µM 0.457421535862734 0.339127532011578 no 1152 0.323684043982727 1569 2985692 SGTC_1063 disulfiram 1.84 µM 0.45621190030719 0.339532848768035 no 1153 0.324118804376773 1538 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_333 3486-0131 40.1 µM 0.456060376894318 0.339583633335436 no 1154 0.324173280991989 1657 6744690 SGTC_127 0180-0333 59.125 µM 0.455479825525018 0.339778237809458 no 1155 0.324382039172656 1526 771601 SGTC_1988 st071872 53.4 µM 0.455056205730236 0.339920264789106 no 1156 0.324534401790034 1579 16414116 SGTC_335 4077-0256 27.6 µM 0.455053651754666 0.339921121129254 no 1157 0.324535320463224 1609 3121989 SGTC_1471 k673-0312 37 µM 0.454618833067889 0.340066926534756 no 1158 0.324691741697673 1547 24099884 SGTC_2511 berberine 10.47 µM 0.452522787655012 0.340770117406907 no 1159 0.325446204362042 1545 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.451560468115297 0.341093146360852 no 1160 0.325792827168906 1534 279621 SGTC_2202 7226349 200 µM 0.449805444048373 0.341682568197158 no 1161 0.326425366024337 1526 844334 SGTC_1554 st069299 38.7 µM 0.448993662043547 0.341955334526252 no 1162 0.32671811435579 1564 24207999 SGTC_2887 9044784 58.44 µM 0.446493001248298 0.342796097934419 no 1163 0.327620583505963 1526 6465546 SGTC_14 0354-0009 295 µM 0.445981374074296 0.342968211584813 no 1164 0.327805350183806 1602 1713507 SGTC_1892 st058411 7.36 µM 0.443913836604417 0.343664071997075 no 1165 0.328552440205028 1633 3934738 SGTC_3270 9137563 49.47 µM 0.44357423286013 0.343778421422208 no 1166 0.328675219274692 1615 17015724 SGTC_2875 9039966 71.43 µM 0.442874246439115 0.344014161919626 no 1167 0.328928348093245 1675 6463691 SGTC_1243 0416-0003 5.65 µM 0.442515773051937 0.344134911597418 no 1168 0.329058009494928 1551 2141977 SGTC_1725 st036284 20.55 µM 0.44197759319613 0.344316224194895 no 1169 0.329252710135319 1721 707914 SGTC_3121 9125696 49.47 µM 0.44038519177826 0.344852913114115 no 1170 0.329829074104854 1617 1235365 SGTC_1579 chlormadinone acetate 49.4 µM 0.439798423479787 0.34505075112775 no 1171 0.330041554786865 1677 45114258 A steroidal progestin. SGTC_2195 6536160 144.242 µM 0.439561532428095 0.345130634618931 no 1172 0.330127353375883 1495 3834386 SGTC_812 4251-0442 148 µM 0.438300794288901 0.345555891924823 no 1173 0.330584125112292 1578 5723007 SGTC_460 trequinsin 123 µM 0.43714255143893 0.345946748610608 no 1174 0.331003984826338 1585 5537 A vasodilator. SGTC_1223 0764-0573 147 µM 0.435852579121858 0.346382251551402 no 1175 0.331471846360945 1556 1609797 SGTC_956 1185-0240 191 µM 0.432319308489319 0.347576145320775 no 1176 0.332754677814672 1584 1416193 SGTC_594 1487-1584 10.8 µM 0.432156003178649 0.347631362941359 no 1177 0.332814016905344 1523 5013332 SGTC_199 4063-0024 41.6 µM 0.431071012484685 0.347998307541093 no 1178 0.333208368548175 1651 306215 SGTC_2999 9069765 71.4286 µM 0.430634178517619 0.348146085312447 no 1179 0.333367192706163 1646 2097066 SGTC_2465 5809242 33.21 µM 0.43014702603851 0.348310912671011 no 1180 0.333544346916188 1645 2731748 SGTC_532 1548-0774 215 µM 0.427761813626578 0.349118359021801 no 1181 0.334412270598489 1696 5932993 SGTC_1750 st081859 2.357 µM 0.424384805908353 0.350262718032894 no 1182 0.335642599916985 1618 5291695 SGTC_2539 epi(13)torulosol 80 µM 0.423049542889727 0.350715571599682 no 1183 0.336129557418324 1551 6708597 SGTC_108 0509-0257 621.132 µM 0.422094945720899 0.351039452716257 no 1184 0.3364778584793 1583 536624 SGTC_675 1309-0189 238 µM 0.421998753082982 0.351072095504663 no 1185 0.336512963793501 1550 4246530 SGTC_206 4546-0025 72.014 µM 0.418637031067316 0.352213578246268 no 1186 0.337740710890266 1595 6620745 YIL048W NEO1 SGTC_3354 9151612 71.43 µM 0.414898685814793 0.353484509486536 no 1187 0.339108035962756 1692 27261949 SGTC_1050 3232-1156 69.3 µM 0.413690800186757 0.353895506542738 no 1188 0.339550282739471 1570 700529 SGTC_616 4092-0450 108 µM 0.412255126951721 0.354384232468522 no 1189 0.34007621753004 1642 787165 SGTC_653 0203-0016 55.2 µM 0.411519724318612 0.354634668143191 no 1190 0.340345740595217 1641 295302 SGTC_1789 tunicamycin 25 nM 0.411402032321682 0.354674753078258 no 1191 0.340388881967722 1579 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_727 3032-0951 202 µM 0.411194276976581 0.354745516783247 no 1192 0.340465042207682 1644 3652836 SGTC_2984 9022109 38.96 µM 0.410938816554286 0.354832536221437 no 1193 0.340558699388796 1636 6459207 SGTC_2408 sulbentine 18.36 µM 0.409737274264916 0.35524192829384 no 1194 0.340999341943272 1678 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1235 benzylparaben 21.5 µM 0.40755193484879 0.35598694998365 no 1195 0.341801329048344 1614 7180 SGTC_2643 anethole 100 µM 0.403673782203391 0.357310435519608 no 1196 0.343226310739974 1617 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2105 5350118 200 µM 0.403214156244533 0.357467404893242 no 1197 0.34339534323371 1591 2133313 SGTC_541 4513-1321 94 µM 0.403029542416887 0.357530460160932 no 1198 0.343463245816919 1570 747515 SGTC_279 1273-0055 2.93 µM 0.401955452045627 0.357897395231071 no 1199 0.343858405813467 1711 2847562 SGTC_1151 3909-8316 15.3 µM 0.401827201724232 0.357941217405216 no 1200 0.34390560077487 1613 800431 SGTC_393 acivicin 6.25 µM 0.40168171764652 0.357990930491101 no 1201 0.343959140547546 1618 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1650 st011916 45.8 µM 0.40126602774358 0.358132988361112 no 1202 0.344112136334107 1716 242528 SGTC_2440 5628896 157.78 µM 0.400628410585989 0.358350925819711 no 1203 0.344346862633763 1644 5522048 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.400547595463659 0.358378551714457 no 1204 0.344376617425864 1593 91467 include heat shock SGTC_1962 st076595 64.5 µM 0.400470739921966 0.358404824751231 no 1205 0.344404915259388 1631 279619 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.400416157565578 0.358423484115418 no 1206 0.344425012744257 1808 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2283 7944793 200 µM 0.398033797181661 0.35923823966 no 1207 0.345302636528335 1555 2970533 SGTC_234 nsc-17383 10.7 µM 0.397830621655605 0.35930775438625 no 1208 0.345377521760934 1714 408974 SGTC_54 0159-0055 9 µM 0.397822678935743 0.359310472012873 no 1209 0.34538044936456 1733 3319099 SGTC_363 0455-0021 3.06 µM 0.397723314276938 0.359344470545354 no 1210 0.345417074922214 1620 4597466 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.397591645779959 0.359389523848938 no 1211 0.345465609821288 1692 5393153 SGTC_1104 tacrolimus 29.8 µM 0.397527265519253 0.359411553698148 no 1212 0.345489342235016 1637 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1040 k898-0338 155 µM 0.396565310214892 0.359740774346028 no 1213 0.34584401889071 1809 20969351 SGTC_2144 5628481 200 µM 0.396483921535687 0.359768633677621 no 1214 0.345874033425829 1649 2818399 SGTC_1337 1486-1011 40.3 µM 0.393467037582089 0.360801837132742 no 1215 0.346987282492977 1604 X1337 SGTC_2546 rhodinyl acetate 100 µM 0.393106328924703 0.360925438564747 no 1216 0.347120474912213 1758 6708682 SGTC_2363 9053361 176 µM 0.391617511003493 0.361435754634299 no 1217 0.347670423717801 1754 6469797 YMR079W SEC14 SGTC_2192 5915882 198.485 µM 0.391067325936685 0.36162440179015 no 1218 0.347873735712441 1635 2876149 SGTC_764 1951-2361 146 µM 0.387496710927234 0.362849508028447 no 1219 0.349194259707324 1577 5438930 SGTC_3319 9138450 16.7555 µM 0.387480884542243 0.36285494132312 no 1220 0.349200116875064 1631 2029690 SGTC_2457 5731572 11.68 µM 0.387432981388707 0.362871386936686 no 1221 0.349217845514291 1768 2865357 SGTC_2485 5633444 17.78 µM 0.383744539150997 0.364138421994622 no 1222 0.350583898909762 1603 5724239 SGTC_187 1488-2104 32.728 µM 0.380692712131972 0.365187894744987 no 1223 0.351715638637028 1725 2852859 SGTC_2121 5257820 149.641 µM 0.379614631489666 0.365558870751377 no 1224 0.352115749063135 1793 791256 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.379179601551542 0.365708603606817 no 1225 0.352277249076598 1674 165521 SGTC_2923 7992654 58.14 µM 0.378891257791686 0.36580785985763 no 1226 0.352384308165452 1647 2985126 SGTC_2904 7225135 42.03 µM 0.376747202236275 0.366546187055502 no 1227 0.353180740403593 1710 4446116 SGTC_2123 5259487 200 µM 0.372986839281105 0.367842297976946 no 1228 0.354579119534359 1774 2173474 SGTC_1269 0831-0796 3.05 µM 0.372568614355495 0.367986543870574 no 1229 0.354734767874232 1738 927758 SGTC_1740 st038286 13.222 µM 0.370976418044117 0.368535863016251 no 1230 0.355327548057172 1699 716786 SGTC_374 0880-0231 82.3 µM 0.370873607513751 0.368571342636272 no 1231 0.355365836824316 1723 6833587 SGTC_865 0488-0499 301 µM 0.370116579749928 0.368832625234601 no 1232 0.355647814546333 1712 9634651 SGTC_514 4466-0038 2.65 nM 0.369379732129469 0.36908700104039 no 1233 0.355922351455673 1713 5722064 SGTC_1951 sophoraflavanone G 9.2 µM 0.36821528204285 0.369489111386269 no 1234 0.356356358099904 1631 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3016 9080866 49.47 µM 0.364381115223823 0.370814140986358 no 1235 0.357786717734537 1632 17066299 SGTC_1401 3807-4679 7.6 µM 0.363880058332819 0.370987412236555 no 1236 0.357973788237154 1666 3291456 SGTC_582 0987-0078 156 µM 0.362625304274758 0.371421435372437 no 1237 0.358442402525562 1698 1625765 SGTC_3174 9107204 49.47 µM 0.362615120242709 0.371424958729001 no 1238 0.358446206839866 1742 3938802 SGTC_2236 dapsone 200 µM 0.357888521885584 0.373061372217475 no 1239 0.360213370394764 1734 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2299 7976368 114.88 µM 0.357492093236713 0.373198725898118 no 1240 0.360361722176274 1795 2979718 SGTC_1098 clofazimine 15.1 µM 0.356740727807426 0.373459101459478 no 1241 0.360642956300469 1756 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2620 irigenin 100 µM 0.35611831940372 0.373674832465463 no 1242 0.360875979245426 1785 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2137 5261020 140 µM 0.355718739705998 0.37381335038904 no 1243 0.361025604774538 1679 763655 SGTC_1307 1187-1599 12.2 µM 0.355710634128279 0.373816160429749 no 1244 0.361028640187342 1677 1538471 SGTC_2065 5221596 34.26 µM 0.355574757817576 0.373863267011285 no 1245 0.361079525055533 1723 788581 SGTC_586 0957-0265 8.15 µM 0.35548654977708 0.373893848620958 no 1246 0.361112559756867 1766 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_552 k242-0005 476 µM 0.355227811337621 0.373983557470651 no 1247 0.361209465595049 1693 4088318 SGTC_894 0960-0238 55.9 µM 0.353180005073257 0.374693805833041 no 1248 0.361976748434358 1742 6741907 YDL195W SEC31 SGTC_1689 st020265 53.493 µM 0.352923219157272 0.374782897917271 no 1249 0.362073001562229 1792 5758320 YPR016C TIF6 SGTC_2879 9041815 71.43 µM 0.352271773377496 0.37500894754022 no 1250 0.362317227341799 1694 4942971 SGTC_3284 9108171 64.8615 µM 0.35178384109377 0.375178286629279 no 1251 0.362500188943296 1708 8687505 SGTC_1047 2043-3044 82 µM 0.350580825863486 0.375595901192924 no 1252 0.362951421689973 1631 669592 SGTC_2029 5175081 200 µM 0.349844968020143 0.375851418695902 no 1253 0.363227524656383 1678 1380876 SGTC_3154 9100113 49.47 µM 0.348811306798803 0.376210436663519 no 1254 0.36361548716837 1660 25237525 SGTC_3045 9092950 49.47 µM 0.34808414515545 0.376463063414752 no 1255 0.363888495505696 1832 44120432 SGTC_2012 4023501 200 µM 0.346894030899886 0.376876640926508 no 1256 0.364335465594225 1658 3477460 SGTC_3085 9117376 49.47 µM 0.346320803537 0.377075894060736 no 1257 0.364550817946785 1744 16480349 SGTC_229 benomyl 22.8748 µM 0.345919451657406 0.377215422974215 no 1258 0.364701624880984 1689 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2421 5690543 90.72 µM 0.343033228181585 0.378219282038996 no 1259 0.365786731315282 1728 3397993 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.342726329345902 0.37832607320611 no 1260 0.365902176561612 1693 688667 SGTC_935 2996-0153 430 µM 0.34264312597653 0.37835502697036 no 1261 0.365933477024917 1861 23738523 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.340371157312934 0.379145907986429 no 1262 0.366788518263659 1785 5282309 SGTC_1829 berberine 14.4 µM 0.338458936687044 0.379811951766376 no 1263 0.367508683385775 1843 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.337075562390677 0.380294016069247 no 1264 0.368029969458336 1709 6708784 An antioxidant flavonoid SGTC_962 1254-0300 21.5 µM 0.336923367465343 0.380347062789647 no 1265 0.368087334738725 1730 7340576 SGTC_3267 9137951 49.47 µM 0.336906228495802 0.380353036626042 no 1266 0.368093794939955 1755 16643986 SGTC_1438 4092-1045 4 µM 0.33655491136838 0.380475495491972 no 1267 0.368226225315053 1709 1351342 SGTC_1333 1482-0047 286 µM 0.335850823548441 0.380720955943177 no 1268 0.368491681117325 1824 3811116 SGTC_499 genistein 192 µM 0.33432716539725 0.381252300859396 no 1269 0.369066346808269 1786 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1900 st060200 72.8 µM 0.333440688709638 0.381561544756744 no 1270 0.369400826788314 1699 688945 SGTC_1569 carminic acid 40.6 µM 0.333182783537446 0.381651528168012 no 1271 0.369498156575053 1861 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_867 0518-0118 155 µM 0.332841434594071 0.381770635041305 no 1272 0.369626989727912 1763 6848158 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.332755954696399 0.381800463291591 no 1273 0.369659254152403 1695 6708561 SGTC_355 1311-2252 105 µM 0.332238924643293 0.381980896124621 no 1274 0.369854426926212 1686 5338538 SGTC_2762 leflunomide 42.06 µM 0.332139495383563 0.382015597827597 no 1275 0.369891964149611 1740 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2950 9072895 21.46 µM 0.332060209106876 0.382043270128248 no 1276 0.369921897742827 1676 17332245 SGTC_1785 bathophenanthroline 24 µM 0.331786503962393 0.382138802652452 no 1277 0.370025237928404 1674 72812 An iron chelator. SGTC_3089 9117425 49.47 µM 0.330536566112629 0.382575165151407 no 1278 0.370497283974712 1663 9401657 SGTC_1552 6-methylflavone 10.6 µM 0.330525320038252 0.382579091916434 no 1279 0.370501532004253 1840 689013 SGTC_3310 9130229 44.1445 µM 0.329456033248831 0.382952507329042 no 1280 0.370905510502456 1814 7761258 SGTC_3130 9127414 49.47 µM 0.328438774327896 0.383307854619237 no 1281 0.371289964902949 1736 1494646 SGTC_1975 st070967 30.8 µM 0.327596023289778 0.383602317478538 no 1282 0.371608564559462 1865 261391 SGTC_1313 1220-0047 237 µM 0.326135024647446 0.38411295942299 no 1283 0.372161099313393 1790 3528706 SGTC_1317 1273-0028 910 nM 0.325301376940729 0.384404422604556 no 1284 0.372476494422311 1724 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2093 5331342 194.4 µM 0.324876649847434 0.384552942502437 no 1285 0.372637214926249 1846 33839 SGTC_2456 5770359 74.46 µM 0.323386208068866 0.385074258788371 no 1286 0.373201386629197 1828 3118787 SGTC_446 go6976 132 µM 0.323372034584108 0.385079217289464 no 1287 0.373206752976041 1865 3501 A protein kinase C inhibitor. SGTC_3104 9120930 49.47 µM 0.323172020691338 0.385149192847158 no 1288 0.373282484604877 1742 17014836 SGTC_978 1416-0512 87.4 µM 0.322095213371885 0.38552598185633 no 1289 0.373690282197327 1771 6814003 SGTC_455 paf C-16 10 µM 0.321234386518113 0.385827274210025 no 1290 0.374016387617081 1732 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.319692667167868 0.386367053342359 no 1291 0.374600659528221 1755 364106 SGTC_1092 toremifene 6.32 µM 0.313690721461844 0.388470511025415 no 1292 0.376877974267011 1785 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3205 9113483 49.47 µM 0.313379276501318 0.388579750752424 no 1293 0.376996263410557 1864 17018033 SGTC_107 0358-0022 2.6945 µM 0.309935960011637 0.389788083997708 no 1294 0.378304828110999 1855 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2569 tetrandrine 100 µM 0.307568130117147 0.390619625358193 no 1295 0.379205486916019 1684 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_16 erodoxin 22.806 µM 0.307253169249534 0.390730272025481 no 1296 0.379325339103267 1787 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_431 k089-0097 107 µM 0.306897909007074 0.390855086598305 no 1297 0.379460540347561 1764 5499420 SGTC_2441 5730946 39.09 µM 0.302399641384554 0.392436444021423 no 1298 0.381173714044922 1855 1774275 SGTC_1445 4239-0156 97.7 µM 0.300989272922545 0.392932623674591 no 1299 0.381711337215615 1899 4008346 SGTC_1147 3809-1045 12.3 µM 0.300880573007212 0.392970872464715 no 1300 0.381752782394682 1766 325925 SGTC_1215 3852-0577 11.2 µM 0.300793203242798 0.393001616455649 no 1301 0.381786095781667 1882 2884876 SGTC_250 brefeldin a 552.239 µM 0.30036350499321 0.393152829950566 no 1302 0.381949948997808 1779 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3351 9150312 21.596 µM 0.299512793878299 0.393452248033904 no 1303 0.382274405862284 1818 4904905 SGTC_572 0960-0087 17.7 µM 0.296661691037505 0.394456186813443 no 1304 0.383362403565314 1709 6796365 SGTC_504 lovastatin 124 µM 0.296115567166883 0.394648569824518 no 1305 0.383570912973833 1721 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1602 st001878 87.6 µM 0.29555812911382 0.394844964981222 no 1306 0.383783776899772 1866 595405 YLR310C CDC25 SGTC_1152 3909-8331 15.9 µM 0.295284942923598 0.394941223005293 no 1307 0.383888108897469 1781 16001939 SGTC_2646 retinol 96.75 µM 0.295183126818098 0.394977099874998 no 1308 0.383926995438336 1799 445354 A vitamin A analog and teratogen. SGTC_776 4476-4378 112 µM 0.293364106255222 0.395618216668842 no 1309 0.384621929067306 1779 2892008 SGTC_271 rotenone 740 µM 0.291978333668772 0.396106824223663 no 1310 0.385151594876716 1877 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2534 helenine 20.12 µM 0.289842736101061 0.396860130910217 no 1311 0.385968275905426 1772 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1065 prochlorperazine maleate 2.48 µM 0.289038196004128 0.397144022881943 no 1312 0.386276074100181 1794 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_520 3584-0023 682 µM 0.287803769614508 0.39757971150177 no 1313 0.386748475834798 1740 1340790 SGTC_2653 dihydrofissinolide 100 µM 0.287509071767163 0.397683743504566 no 1314 0.386861278384264 1836 6857746 SGTC_371 0195-0006 7.36 µM 0.286936685528926 0.397885823746829 no 1315 0.387080400015286 1724 3928593 SGTC_1046 2001-0062 216 µM 0.28646929604755 0.398050855339886 no 1316 0.387259353350242 1766 739778 SGTC_2400 5203494 178.7 µM 0.284189719247267 0.39885601710962 no 1317 0.388132496829896 1762 6777674 SGTC_3004 9076122 71.4286 µM 0.283135995363818 0.39922834516969 no 1318 0.388536294865288 1885 44782551 SGTC_2935 9038016 29.96 µM 0.282269116149099 0.399534721361468 no 1319 0.388868582420266 1940 6463195 SGTC_2850 9015429 58.44 µM 0.281299981446519 0.399877310377113 no 1320 0.389240162269702 1765 6457570 SGTC_2274 7947094 46.08 µM 0.28126576880521 0.399889405952369 no 1321 0.389253281729956 1786 2971028 SGTC_1922 5578187 25 µM 0.27959165301911 0.400481391840458 no 1322 0.389895405866583 1914 1350412 SGTC_666 0272-0154 136 µM 0.278251765631013 0.400955355692698 no 1323 0.390409549972838 1843 6870312 SGTC_2176 5809774 33.9695 µM 0.277422007609168 0.40124894255382 no 1324 0.39072804246138 1955 2870539 SGTC_2983 9022671 12.99 µM 0.276924177530329 0.401425112695053 no 1325 0.390919163666256 1976 6405161 SGTC_1893 st059353 36.1 µM 0.276497232201183 0.401576214385067 no 1326 0.391083092603255 1780 3112488 SGTC_792 4534-1957 155 µM 0.276262622545914 0.401659252162239 no 1327 0.39117318102251 1837 1717904 SGTC_390 dec-rvkr-cmk 16.7 µM 0.275571438912223 0.401903915600996 no 1328 0.39143862448842 1861 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_890 0929-0006 47.2 µM 0.274544398595169 0.402267535726662 no 1329 0.391833144341272 1767 1378169 SGTC_1675 st018485 24.5 µM 0.273615776333744 0.4025963841046 no 1330 0.392189954379655 1809 3323024 SGTC_1463 k081-0032 34.1 µM 0.273489579623037 0.402641078842858 no 1331 0.392238450694768 1811 977755 SGTC_2187 6125751 200 µM 0.273052027411451 0.402796055344653 no 1332 0.392406611220388 1850 874498 SGTC_402 epigallocatechin gallate 10 µM 0.27230229417546 0.403061638656141 no 1333 0.392694796177448 1799 65064 An antioxidant. SGTC_3022 9087993 49.47 µM 0.269889448702994 0.403916660997092 no 1334 0.393622652392657 1872 17173644 SGTC_497 capsazepine 133 µM 0.269316903460191 0.404119617228396 no 1335 0.393842912747309 1733 2733484 A calcium channel blocker. SGTC_3334 9142812 21.919 µM 0.268540653437976 0.404394824079737 no 1336 0.394141593343255 1891 45283678 SGTC_749 1000-0129 128 µM 0.264288926930753 0.405903040568196 no 1337 0.395778646032381 1961 708470 SGTC_2293 7624732 200 µM 0.261708769101916 0.406818983838682 no 1338 0.396772989672763 1810 894453 SGTC_527 4476-4215 268 µM 0.258297761358183 0.408030656692189 no 1339 0.398088556920174 1850 4418754 SGTC_3070 9117005 49.47 µM 0.257279931630934 0.408392385558024 no 1340 0.398481341690205 1913 8779016 SGTC_2136 5328288 199.296 µM 0.255491829934708 0.40902805203748 no 1341 0.399171626523024 1815 262395 SGTC_2352 9027995 87.8 µM 0.254607110796707 0.409342656481178 no 1342 0.399513283265675 1889 2997347 SGTC_3339 9145883 14.936 µM 0.254472777243054 0.409390430348966 no 1343 0.399565166312598 1936 2030670 SGTC_1941 st076221 61.8 µM 0.254240277145901 0.409473118967901 no 1344 0.399654967974883 1992 2828568 SGTC_1126 isoteolin 1.0172 µM 0.254155643871745 0.409503219777103 no 1345 0.399687658349024 1781 133323 SGTC_1573 oleylamine 1.06 µM 0.253826344374268 0.409620344051437 no 1346 0.399814859972419 1810 5356789 An amine of the fatty acid oleic acid. SGTC_1278 0874-0585 172 µM 0.252346042894895 0.410146952804573 no 1347 0.400386801132404 1896 766306 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.250694257464856 0.410734757287856 no 1348 0.401025250407215 1939 17037758 SGTC_1710 st031758 61.5 µM 0.250082972421282 0.410952340136481 no 1349 0.401261591859976 1965 5394341 SGTC_858 0438-0351 2.77 µM 0.248679799044052 0.411451893906221 no 1350 0.401804238037418 1843 2799119 SGTC_170 4197-0004 226 µM 0.248595414699627 0.411481940764261 no 1351 0.401836877857847 1911 218692 SGTC_2606 farnesol 9.78 µM 0.248403311617679 0.411550345128072 no 1352 0.401911185783107 1962 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_609 0986-0026 86.3 µM 0.248205405757784 0.411620818565647 no 1353 0.401987742005225 1900 2848610 SGTC_290 2043-6722 48.1 µM 0.246905874023843 0.412083647035428 no 1354 0.402490535117165 1907 773758 YLR208W SEC13 SGTC_327 1273-0057 3.96 µM 0.245671138178821 0.412523511767457 no 1355 0.402968407984176 1956 3108138 SGTC_2018 5133068 143 µM 0.243468571285786 0.413308431043458 no 1356 0.403821214589289 1865 785362 SGTC_800 3448-7362 155 µM 0.243393892433571 0.413335050117209 no 1357 0.403850137355218 1945 15991913 SGTC_2140 5586273 200 µM 0.241639999763347 0.413960334679164 no 1358 0.404529562517594 1910 854421 SGTC_3253 9135987 49.47 µM 0.240819546824275 0.41425291136491 no 1359 0.404847489611199 1923 4182430 SGTC_482 fipronil 114 µM 0.240383868750435 0.414408295203982 no 1360 0.405016341254031 1921 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1236 0330-0013 258 µM 0.238139777640869 0.415208858147924 no 1361 0.405886341962679 1865 4617066 SGTC_2078 5212016 200 µM 0.237667916628192 0.415377236003579 no 1362 0.406069334764061 2020 1899708 SGTC_278 4092-0821 23.9 µM 0.236295762270505 0.415866960775113 no 1363 0.406601587531994 1946 877900 SGTC_2328 6201408 200 µM 0.235355109983253 0.416202757098677 no 1364 0.406966562281238 1851 2890418 SGTC_1735 st034310 56.75 µM 0.234839330787359 0.416386907185366 no 1365 0.407166719842714 1945 871153 SGTC_1089 terbinafine 2.25 µM 0.234781131649542 0.416407687339173 no 1366 0.407189306607026 1997 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_71 0417-1750 47.813 µM 0.23422987064936 0.416604528095055 no 1367 0.407403263256369 2030 6811472 SGTC_1715 st032160 10.2275 µM 0.233602076204183 0.416828722392213 no 1368 0.407646957881775 1972 5289825 SGTC_2068 5226020 147 µM 0.233232602467269 0.416960679352337 no 1369 0.407790395366644 1842 1810509 SGTC_158 k038-0087 26.446 µM 0.233204932659896 0.416970561956968 no 1370 0.407801137866274 1879 X158 SGTC_752 1896-0090 130 µM 0.233117145993833 0.417001916368267 no 1371 0.407835220536592 1871 772567 SGTC_87 0100-0052 35.5 µM 0.232829105257185 0.417104798429246 no 1372 0.407947055600445 1921 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_3272 9137413 49.47 µM 0.231741021249941 0.417493490197298 no 1373 0.408369584092694 1865 17614870 SGTC_2398 5228213 48.84 µM 0.231224610005225 0.4176779938982 no 1374 0.408570155984129 2057 80771 YMR134W ERG29 SGTC_373 0844-0104 25.9 µM 0.231164990443872 0.417699295976439 no 1375 0.408593313506766 2014 5375804 SGTC_1815 st051655 58.2 µM 0.229692955816864 0.418225330612045 no 1376 0.409165184510654 2026 5984156 SGTC_45 0kpi-0036 14.9 µM 0.228785744484247 0.418549597398711 no 1377 0.409517723604007 1919 2795021 SGTC_249 wiskostatin 11.211 µM 0.225882743928529 0.419587594990848 no 1378 0.410646309670876 2000 2775510 A n-wasp and actin depolymerizer. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.224150131480065 0.420207375540384 no 1379 0.411320242727663 2039 756377 SGTC_2611 pyromycin 23.93 µM 0.223864803596451 0.420309460474478 no 1380 0.411431251672106 1851 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1109 tnp00067 928.257 nM 0.223656569467025 0.420383966101898 no 1381 0.411512271191965 1886 676295 SGTC_2586 curcumin 80 µM 0.222339885387957 0.420855138164698 no 1382 0.412024652498499 1983 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_789 1309-1135 70.6 µM 0.2219625849539 0.420990175101234 no 1383 0.412171504847422 1901 3092424 SGTC_3083 9117465 49.47 µM 0.221883891505141 0.421018340890444 no 1384 0.412202135352596 1843 16420915 SGTC_2468 5987765 72.9 µM 0.221316974473498 0.421221262547572 no 1385 0.412422816975495 1943 26772094 SGTC_3191 9110352 49.47 µM 0.220749235631063 0.421424499335983 no 1386 0.41264384625204 1937 17122424 SGTC_2807 7945238 51.95 µM 0.220537850818317 0.421500175343096 no 1387 0.412726148622339 1917 17148797 SGTC_2285 7945142 200 µM 0.217630835375099 0.422541183181399 no 1388 0.413858378567447 1898 2970608 SGTC_2949 9072542 2.23 µM 0.217144136040866 0.422715524242671 no 1389 0.414048009428689 1871 16457352 SGTC_26 0302-0163 425.158 µM 0.213753190175051 0.4239306167445 no 1390 0.415369765019067 1940 3100915 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.213636236696685 0.423972538171382 no 1391 0.415415369454766 1886 2724 A muscle relaxant with antifungal properties. SGTC_1596 piperlongumine 63 µM 0.213083169650894 0.424170794111452 no 1392 0.415631045934841 2045 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1441 4106-0040 13 µM 0.212705542373176 0.42430617182145 no 1393 0.415778321750995 2015 2904180 SGTC_948 3448-0295 75.3 µM 0.211982417845622 0.424565433681209 no 1394 0.416060375572084 1927 678569 SGTC_2857 9024691 58.44 µM 0.211440504452584 0.42475974730905 no 1395 0.416271776567254 1908 16478292 SGTC_1405 3909-7894 12 µM 0.210551587307278 0.425078525482354 no 1396 0.41661859652826 2024 7104060 SGTC_105 0111-0055 734.78 µM 0.208656334071095 0.425758353249756 no 1397 0.417358265060169 1957 5179370 SGTC_2330 7979373 200 µM 0.208534274168005 0.425802143752245 no 1398 0.417405911952004 1818 1863007 SGTC_2296 7971656 126.45 µM 0.207106364866425 0.42631449173503 no 1399 0.417963395710122 1901 666570 SGTC_2043 5101342 149 µM 0.206916503248447 0.426382625349405 no 1400 0.41803753384783 1958 678451 SGTC_451 chloral hydrate 100 µM 0.206496948763075 0.426533194183309 no 1401 0.418201373959537 1949 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3179 9107801 49.47 µM 0.205762488350283 0.426796801562459 no 1402 0.418488222060923 1939 4818259 SGTC_2968 9090663 33.37 µM 0.205156419937753 0.427014352014883 no 1403 0.418724958518756 1912 25236811 SGTC_3290 9121031 71.43 µM 0.204907310386731 0.427103777232397 no 1404 0.418822271772494 1903 17014854 SGTC_1591 genipin 88.4 µM 0.204571053005328 0.42722449267338 no 1405 0.418953636716074 2028 442424 A DNA cross-linking agent. SGTC_3128 9127691 49.47 µM 0.204275569210431 0.42733057613884 no 1406 0.419069080190815 1960 41316314 SGTC_1846 st056244 14.8 µM 0.202696447239315 0.427897595385318 no 1407 0.419686150114815 1967 5393182 SGTC_3044 9093193 49.47 µM 0.201545603705059 0.428310925518196 no 1408 0.420135987171041 1881 25236277 SGTC_2795 7780010 54.55 µM 0.20088009552147 0.428549981411766 no 1409 0.420396165968792 1954 953673 SGTC_3055 9094636 49.47 µM 0.200187960186587 0.428798629804313 no 1410 0.420666791485105 2006 25236176 SGTC_2556 citropten 84.59 µM 0.199456952413593 0.429061273737098 no 1411 0.420952656873897 1882 2775 A potential DNA crosslinker. SGTC_1982 st072467 71.9 µM 0.199292604406403 0.429120326695354 no 1412 0.421016931985483 1913 3163533 SGTC_2729 fluphenazine 10.66 µM 0.19878115501542 0.429304109068591 no 1413 0.421216968966537 1989 3372 An atypical antipsychotic. SGTC_1927 st060202 13.8 µM 0.19839922938422 0.429441358839787 no 1414 0.421366360161604 2069 688887 SGTC_1556 plumbagin 1.48 µM 0.198295362837143 0.429478686063608 no 1415 0.421406989788028 2040 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_953 1188-0045 9.7 µM 0.194515662641647 0.430837448822143 no 1416 0.422886066463122 1991 6144426 SGTC_1349 flufenamic acid 69 µM 0.194033139508116 0.431010970146157 no 1417 0.42307496670421 1955 3371 A non-steroidal anti-inflammatory. SGTC_2022 5136654 200 µM 0.193844085380459 0.431078959996382 no 1418 0.42314898325566 1977 1713771 SGTC_1483 3453-0561 55.9 µM 0.193715477205057 0.431125212735745 no 1419 0.423199336172382 2032 4546991 SGTC_1028 k015-0029 4.8 µM 0.193331393511906 0.43126335049968 no 1420 0.423349720812679 1930 4588309 SGTC_1444 4112-3581 28 µM 0.193258205038898 0.431289674081493 no 1421 0.423378378392171 1973 2877249 SGTC_1281 0884-0031 11.8 µM 0.192436753384057 0.431585145201809 no 1422 0.423700052662427 1925 1548255 SGTC_1200 1643-0193 18.4 µM 0.18957451759917 0.432614971896739 no 1423 0.42482127854405 2080 5403974 SGTC_1700 st030840 7.9285 µM 0.186262539025338 0.43380718621336 no 1424 0.426119441437968 2095 5499307 SGTC_1923 st058458 19.1 µM 0.185431157214523 0.434106554093889 no 1425 0.426445436118 2092 3534982 SGTC_2978 9011784 42.97 µM 0.185087086955086 0.434230459602045 no 1426 0.426580364869161 2111 2994934 SGTC_1061 3448-9325 110 µM 0.184242353458636 0.434534689774595 no 1427 0.426911667449376 2120 723482 SGTC_1878 temozolomide 1 mM 0.183005497813026 0.434980212358451 no 1428 0.42739685241982 2115 5394 DNA alkylating agent. SGTC_2323 6148992 148.28 µM 0.18247049328282 0.435172949709817 no 1429 0.427606754278591 1949 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1319 1306-0155 43.7 µM 0.18147888367671 0.435530221418874 no 1430 0.427995853166221 2018 3122360 SGTC_1087 pterostilbene 9.05 µM 0.180211407814796 0.435986962872785 no 1431 0.428493301455528 2072 5281727 Similar to reservatol, lowers cholesterol. SGTC_2981 9013952 38.96 µM 0.17781115123815 0.43685214115679 no 1432 0.429435644743601 1860 2996344 SGTC_2794 7785382 27.27 µM 0.177520623533064 0.436956883150251 no 1433 0.429549733626791 2131 2205081 SGTC_344 k064-0035 6.43 µM 0.177181113703241 0.437079289938056 no 1434 0.429683065018647 1893 5088750 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.176740413763731 0.437238188764912 no 1435 0.429856147480249 1943 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1801 st050089 28.441 µM 0.176001593035906 0.437504600762889 no 1436 0.430146345461303 2041 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1969 st069479 40.1 µM 0.174832318701232 0.437926288257504 no 1437 0.43060569638885 2094 3895485 SGTC_222 nsc-310342 10.666 µM 0.173776748974007 0.438307029848941 no 1438 0.431020458990559 2115 432556 SGTC_3148 9097893 49.47 µM 0.173025453524899 0.438578055212727 no 1439 0.431315710171546 1927 17174100 SGTC_2780 5215298 71.43 µM 0.172819901200709 0.4386522120149 no 1440 0.431396496759362 2136 2834131 SGTC_277 nystatin 15.5 µM 0.171830075675953 0.439009339988386 no 1441 0.431785560102558 2020 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3028 9087778 49.47 µM 0.171496328548307 0.439129766797587 no 1442 0.431916758536259 2018 17217395 SGTC_1842 st055362 61.2 µM 0.171137513497379 0.439259245212834 no 1443 0.432057819730105 2012 676032 SGTC_389 tpck 16.7 µM 0.170687421433686 0.439421670126518 no 1444 0.432234776961114 1985 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2046 4110841 106 µM 0.170451870405008 0.439506677593139 no 1445 0.432327391120099 2142 44119630 YMR134W ERG29 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.169441990777934 0.439871162287317 no 1446 0.432724498557613 1949 688669 SGTC_228 caffeine 993.056 µM 0.16790798784705 0.440424910425691 no 1447 0.433327832978441 2116 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3074 9116018 49.47 µM 0.165777030753224 0.441194341697316 no 1448 0.434166211394479 2011 17027303 SGTC_83 0170-0301 39.027 µM 0.165002881794501 0.441473921187864 no 1449 0.434470856902508 2127 3089716 SGTC_2442 5158906 48.48 µM 0.164413937690796 0.441686634539897 no 1450 0.434702646094048 2089 1893835 SGTC_3194 9111903 49.47 µM 0.164167275307337 0.441775728440653 no 1451 0.434799731036982 2045 17087251 SGTC_1380 2291-0730 164 µM 0.162926999367547 0.442223757888958 no 1452 0.435287956218656 1980 2999191 SGTC_1320 1313-0481 95.3 µM 0.162132995686769 0.442510617605697 no 1453 0.435600561570465 2103 6813365 YLR208W SEC13 SGTC_3224 9130643 49.47 µM 0.162062827072611 0.442535969757133 no 1454 0.435628189431448 2049 17644395 SGTC_1314 1222-0010 41.1 µM 0.160105580970977 0.4432432236774 no 1455 0.436398952455838 2024 3526027 SGTC_300 r073-0011 5.04 µM 0.159226292586702 0.443561014912702 no 1456 0.436745294812446 2159 2735780 SGTC_542 3381-0244 89.3 µM 0.157793251373838 0.444079020459062 no 1457 0.43730985832969 2137 1112843 SGTC_3030 9087619 49.47 µM 0.157379038360731 0.444228765072328 no 1458 0.43747306627555 2039 25236973 SGTC_2499 avocadenofuran 51.48 µM 0.156129680670283 0.444680475949462 no 1459 0.43796540172369 1958 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1490 4089-0339 670 nM 0.155234674300673 0.445004113725144 no 1460 0.438318156735751 2136 742542 SGTC_1738 st035555 74 µM 0.154230126253399 0.445367405853128 no 1461 0.43871414452797 2048 5331140 SGTC_583 1488-1091 88.9 µM 0.154015072397832 0.445445185480807 no 1462 0.43879892566394 2175 4303273 SGTC_244 nsc-207895 1.295 µM 0.153883360537514 0.445492823419968 no 1463 0.438850852095842 2047 42640 SGTC_2221 6807166 181.081 µM 0.153867647615784 0.445498506569004 no 1464 0.438857046869916 2105 674925 SGTC_848 0368-0089 85.6 µM 0.153049174296405 0.445794552640663 no 1465 0.439179748289103 2128 762535 SGTC_3165 9101544 49.47 µM 0.152331583453182 0.446054133865859 no 1466 0.439462707801118 2093 5002184 SGTC_2681 menadione 3.18 µM 0.152056979059892 0.446153475349427 no 1467 0.439570997648704 2053 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2659 sanguinarine 24.21 µM 0.150719095986176 0.446637519080251 no 1468 0.440098654449034 2063 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_912 3474-0017 2.18 µM 0.150697799019287 0.446645224930087 no 1469 0.440107054767449 2090 3360550 SGTC_1871 st057448 67.3 µM 0.150106660062816 0.446859123889345 no 1470 0.440340232776202 2109 691747 SGTC_217 ketoconazole 989 nM 0.150013963578383 0.446892666783429 no 1471 0.440376799292469 2099 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1797 st048695 56.8 µM 0.149805429870463 0.446968127603951 no 1472 0.44045906264385 2138 592262 YIL048W NEO1 SGTC_3287 9117173 37.0625 µM 0.149719862923519 0.446999091748676 no 1473 0.440492818236648 2167 2789709 SGTC_1637 st007924 17.4 µM 0.146822632519099 0.448047703121241 no 1474 0.441636010055197 2102 683336 SGTC_1674 st016616 23.6 µM 0.146534255761668 0.448152096982258 no 1475 0.441749824789775 1979 625830 SGTC_778 3456-2434 196 µM 0.145508077048891 0.448523607998486 no 1476 0.442154869528863 2164 5539063 SGTC_202 3594-0513 34.79 µM 0.145092102120873 0.448674217713334 no 1477 0.442319076949879 2145 708429 SGTC_148 3253-0744 288.01 µM 0.143878646902985 0.44911360883907 no 1478 0.442798148766372 2190 6893655 SGTC_1023 4482-3888 16 µM 0.141030299024512 0.450145237494572 no 1479 0.443923003196235 2158 3303168 SGTC_50 0929-0078 56.389 µM 0.140491741822232 0.450340332885292 no 1480 0.444135738425778 2098 1377751 SGTC_1778 st046819 58.9 µM 0.140293991539669 0.450411972057685 no 1481 0.444213855716328 2048 671715 SGTC_2058 5236698 133 µM 0.139890197852299 0.45055825977476 no 1482 0.444373373057011 2066 766665 SGTC_1784 st039334 36.3 µM 0.138802918984198 0.450952196110141 no 1483 0.444802943650281 2175 3496984 SGTC_2753 fluvastatin 17.09 µM 0.138126980685582 0.451197122386427 no 1484 0.445070031325097 2086 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1874 staurosporine 7.6 µM 0.136041838793163 0.451952790323061 no 1485 0.445894102915078 2142 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_324 1315-0088 19.6 µM 0.135190990530507 0.452261193012861 no 1486 0.446230435107389 2126 6787421 SGTC_1912 st060209 90.8 µM 0.133997819962562 0.452693724027909 no 1487 0.446702149153477 2034 688787 SGTC_3192 9110362 49.47 µM 0.131534965996593 0.453586699355153 no 1488 0.447676063993136 2147 16649480 SGTC_1719 st032227 49.2 µM 0.129844877280422 0.454199623497358 no 1489 0.448344578250237 2067 3125804 SGTC_2425 5628681 7.85 µM 0.129758075019011 0.454231105986788 no 1490 0.448378916844862 2116 5714958 SGTC_2614 arthonioic acid 13.39 µM 0.128725910769118 0.454605485730633 no 1491 0.448787266076034 2182 6710684 SGTC_1060 3448-7350 82 µM 0.128667565306068 0.454626649615863 no 1492 0.448810350581723 2170 570178 SGTC_607 4491-0986 66.8 µM 0.128328013988933 0.454749818989316 no 1493 0.448944698214047 2164 698981 YDR232W HEM1 SGTC_2813 7971799 71.43 µM 0.127768430253214 0.454952812752488 no 1494 0.449166117130904 2086 2234054 SGTC_1936 st074407 74.3 µM 0.126507197901727 0.45541037857931 no 1495 0.4496652258612 2059 809813 SGTC_106 0092-0003 11.579 µM 0.125507321535803 0.455773168444476 no 1496 0.45006096456252 2189 1072148 SGTC_1 0258-0098 57.368 µM 0.124056946935269 0.456299480180286 no 1497 0.450635093061592 2080 6790032 YDR047W HEM12 SGTC_2682 pyrogallin 40.03 µM 0.122770626771761 0.456766324056979 no 1498 0.451144367351844 2186 822798 An ATP competetive kinase inhibitor. SGTC_2973 9094665 17.96 µM 0.121992930838337 0.45704860204879 no 1499 0.451452308414236 2175 25237061 YIL048W NEO1 SGTC_2593 nobiletin 86.24 µM 0.121527175785848 0.457217666167574 no 1500 0.45163674552828 2073 72344 An anti-infammatory. SGTC_2467 5474540 200 µM 0.12151969984896 0.457220379916186 no 1501 0.451639706054239 2169 5413519 SGTC_441 propafenone 146 µM 0.121353235868545 0.457280806490664 no 1502 0.451705627710458 2161 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2716 st080858 38.6235 µM 0.121337820735765 0.457286402247701 no 1503 0.451711732348232 2196 5296050 SGTC_819 1013-0258 27.7 µM 0.119028515703235 0.458124784579289 no 1504 0.45262638205457 2107 5753198 SGTC_1256 0570-0116 285 µM 0.118695352261035 0.45824575346866 no 1505 0.452758359437907 2084 410638 SGTC_1435 4092-0789 56.7 µM 0.118166317820449 0.458437849438892 no 1506 0.452967938710817 2206 2248285 SGTC_1557 sumaresinolic acid 42.3 µM 0.117747492663628 0.458589934562185 no 1507 0.453133867396188 2144 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2945 9067681 61.76 µM 0.117251116460377 0.458770188115837 no 1508 0.453330530577692 2196 16456930 SGTC_1578 josamycin 24.2 µM 0.117029313083909 0.458850736312893 no 1509 0.453418412300168 2035 5282165 A P450 substrate. SGTC_1948 st076329 66.6 µM 0.116153586298698 0.45916877415476 no 1510 0.453765410227029 2208 24208413 SGTC_2867 9039098 71.43 µM 0.116079327010823 0.459195744117506 no 1511 0.453794836349813 2205 6463460 SGTC_1025 k007-0731 70 µM 0.115557170033045 0.459385389721522 no 1512 0.454001754393082 2022 6256118 SGTC_420 mitomycin C 81.9 mM 0.112483086362282 0.460502072212255 no 1513 0.455220189878708 2097 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1237 0330-0133 46.1 µM 0.11185335489824 0.46073086532968 no 1514 0.455469840912171 2147 X1237 YHR072W ERG7 SGTC_2966 9084041 48.03 µM 0.111802385665645 0.460749383966662 no 1515 0.455490047948939 2069 17741380 SGTC_1505 k297-0037 20.6 µM 0.111210043052575 0.460964605874929 no 1516 0.455724893916068 2059 4089396 SGTC_2786 7743617 45.45 µM 0.110570607394823 0.461196951413761 no 1517 0.455978428216283 2080 583674 SGTC_581 0958-0271 211 µM 0.109450666509932 0.461603925349921 no 1518 0.456422524514412 2146 4591145 SGTC_1137 ixabepilone 100 µM 0.105968079023207 0.46286971354331 no 1519 0.457803839399748 2197 154225 A novel microtubule stabilizer. SGTC_2917 7979103 53.79 µM 0.105719238429927 0.462960172188489 no 1520 0.457902557915786 2180 2980565 SGTC_79 0052-0007 94.094 µM 0.103688893331387 0.463698315314711 no 1521 0.458708120489828 2216 2801472 SGTC_3239 9133757 49.47 µM 0.10360498780413 0.463728822337272 no 1522 0.458741414636728 2180 17036923 SGTC_2250 alverine citrate 130 µM 0.101849381102843 0.464367188087745 no 1523 0.459438114480234 2160 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2174 5790901 200 µM 0.100215747006204 0.46496128514527 no 1524 0.460086522323748 2146 786020 SGTC_20 0481-0013 4.944 µM 0.0999136102077867 0.465071170602932 no 1525 0.460206455519151 2160 182045 SGTC_1185 1319-0113 81.3 µM 0.0982769506701165 0.46566646057159 no 1526 0.4608561901344 2153 4672763 SGTC_3320 9137005 35.139 µM 0.0966313465459561 0.466265081351945 no 1527 0.461509581016159 2071 4908713 SGTC_696 1560-0013 611 µM 0.096099073256797 0.466458722604351 no 1528 0.461720943667973 2196 1650269 SGTC_2490 carminic acid 95.39 µM 0.093874547951496 0.467268091281956 no 1529 0.46260440616377 2250 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2889 9059656 51.95 µM 0.0929998746400079 0.467586368651424 no 1530 0.462951830407406 2187 3949838 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.0923627873116637 0.467818205951112 no 1531 0.463204902215474 2187 6708514 SGTC_2826 7992541 19.48 µM 0.0914529666299581 0.468149310347319 no 1532 0.463566338376269 2266 2985066 SGTC_2878 9043973 25.97 µM 0.0912352824747929 0.468228533827428 no 1533 0.463652820244228 2222 6465167 SGTC_1832 st054113 55 µM 0.0907992938569321 0.468387210321591 no 1534 0.463826035577718 2261 1251267 SGTC_1000 4048-0884 8.67 µM 0.0903880407242228 0.468536889028046 no 1535 0.463989429955333 2168 13040088 SGTC_997 3996-0078 137 µM 0.0903607554785005 0.468546819858373 no 1536 0.464000270831361 2177 735687 SGTC_945 3381-0768 11.3 µM 0.0897672676884144 0.468762832514008 no 1537 0.464236079872615 2246 1126236 YIL048W NEO1 SGTC_2418 pentamidine 31.67 µM 0.0894941266703768 0.468862251160638 no 1538 0.464344610546775 2257 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3331 9141060 1.957 µM 0.0894725598908374 0.468870101181344 no 1539 0.464353180068979 2118 4906567 YPR165W RHO1 SGTC_694 1315-0438 43.2 µM 0.0893325394774156 0.46892106704242 no 1540 0.464408817337852 2188 6793154 SGTC_1361 1608-0041 5.61 µM 0.087782855392061 0.469485168503858 no 1541 0.465024632284964 2200 X1361 SGTC_1560 lithocholic acid 53.1 µM 0.0866125350447729 0.469911218195886 no 1542 0.465489750910881 2243 9903 A bile acid which acts as a detergent. SGTC_2486 5283202 22.39 µM 0.085963251204565 0.470147601854337 no 1543 0.465747815170008 2134 1377751 SGTC_1036 k216-0215 33.5 µM 0.0857240201444108 0.470234700954391 no 1544 0.465842903548906 2266 622330 SGTC_754 3474-0146 171 µM 0.0849377683104666 0.470520969056917 no 1545 0.466155432747716 2167 24762078 SGTC_2240 6690706 185.951 µM 0.0845463880711017 0.470663473209287 no 1546 0.466311011246127 2189 805876 SGTC_156 3474-0145 5.642 µM 0.084232922893808 0.470777610678824 no 1547 0.46643562125516 2266 2265471 SGTC_1837 st055472 66.5 µM 0.0839547497481236 0.470878899790089 no 1548 0.466546204581683 2210 676091 SGTC_797 k781-0471 270 µM 0.0838606358128375 0.470913169221727 no 1549 0.466583618670574 2200 23738129 SGTC_1325 1431-0015 227 µM 0.0825456275856994 0.471392021732667 no 1550 0.467106418270057 2108 1103340 SGTC_651 3253-0966 34.4 µM 0.0822398497877298 0.471503374871611 no 1551 0.46722799260294 2201 781462 SGTC_964 1287-0107 19.4 µM 0.0820107706206146 0.471586798622345 no 1552 0.467319074296304 2232 51516812 YPR165W RHO1 SGTC_309 k408-0051 1.48 µM 0.0800518978085376 0.472300211787241 no 1553 0.468097989946422 2211 3640463 SGTC_2568 diosmetin 100 µM 0.0793096821979757 0.472570546903721 no 1554 0.468393152640915 2276 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_821 1114-0266 29.2 µM 0.0787235997620792 0.472784023004776 no 1555 0.468626236918157 2192 3123235 SGTC_3038 9091290 49.47 µM 0.0760722694797334 0.473749846814195 no 1556 0.469680800972492 2262 25236843 SGTC_384 k007-0144 5.16 µM 0.0750808846533346 0.474111027381396 no 1557 0.470075178363802 2192 6824886 SGTC_2368 9071271 200 µM 0.0744616203885441 0.474336648085162 no 1558 0.470321539424059 2208 27209959 SGTC_2219 9098279 200 µM 0.0736024750934404 0.474649679870026 no 1559 0.470663350821788 2284 902349 SGTC_2344 7990960 76.95 µM 0.0728079475100124 0.474939181959985 no 1560 0.470979473273043 2195 140813 SGTC_2769 toremifene 3.73 µM 0.0727286635599866 0.474968071388891 no 1561 0.471011019360357 2239 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_568 1193-0097 7.48 µM 0.0712916585145346 0.475491708918408 no 1562 0.471582816939841 2256 3646150 SGTC_2473 5854593 8.94 µM 0.0696118759913669 0.476103866961097 no 1563 0.472251292099535 2223 2872951 SGTC_1122 capsaicin 818.572 nM 0.0695737002441761 0.476117779893656 no 1564 0.472266485183353 2215 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_673 1082-0474 110 µM 0.0687913518789164 0.47640290866563 no 1565 0.472577850991106 2258 3098046 SGTC_58 0957-0393 9 µM 0.06879027160292 0.476403302383242 no 1566 0.472578280940373 2265 6997992 SGTC_671 0560-0003 407 µM 0.0673429644629328 0.476930808776871 no 1567 0.473154336902025 2244 3238678 SGTC_1730 st033808 45.1 µM 0.0672918449889314 0.476949441260796 no 1568 0.473174684465438 2083 1045166 SGTC_2793 7325131 81.82 µM 0.0671154808936415 0.477013724413089 no 1569 0.473244884856435 2231 4176441 SGTC_3024 9090631 49.47 µM 0.0656505015864118 0.477547719371645 no 1570 0.473828040676569 2296 25236383 SGTC_1008 4106-0037 6 µM 0.0652390917364072 0.47769768836236 no 1571 0.473991818351696 2288 2905394 SGTC_645 0845-0943 5.41 µM 0.0647192110570199 0.477887202147824 no 1572 0.474198783338493 2226 1885106 SGTC_2466 5983409 37.09 µM 0.0632136526941676 0.478436056263573 no 1573 0.474798186622761 2180 2879657 SGTC_2815 7968870 71.43 µM 0.0603521686522199 0.479479327494559 no 1574 0.475937576528719 2282 2977326 YHR190W ERG9 SGTC_2313 7726885 200 µM 0.0594781916187243 0.479797999984818 no 1575 0.476285617643432 2253 726423 SGTC_3238 9133470 49.47 µM 0.0593698896662848 0.479837490315881 no 1576 0.47632874765332 2309 3534688 SGTC_1001 4048-4355 44.4 µM 0.0593431594877896 0.479847237018261 no 1577 0.476339392682889 2283 21824233 SGTC_1048 3161-0300 24.5 µM 0.058455500520484 0.480170913486218 no 1578 0.476692903643894 2295 2165101 SGTC_3304 9125678 46.087 µM 0.0579778427671189 0.480345092304035 no 1579 0.476883138871374 2276 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2061 5245884 80.95 µM 0.0574388704745149 0.480541634091024 no 1580 0.477097799968476 2288 573863 SGTC_386 1509-0011 3.07 µM 0.0564826171441468 0.480890353309271 no 1581 0.477478671463001 2297 3107280 SGTC_3082 9117008 49.47 µM 0.0558057346396266 0.481137202546927 no 1582 0.477748283241864 2199 41448529 SGTC_2327 6189656 200 µM 0.0550847541774548 0.481400141623286 no 1583 0.478035471053109 2292 5349088 SGTC_1411 3909-8223 150 µM 0.0550747423035126 0.481403792976249 no 1584 0.478039459158825 2328 X1411 SGTC_2366 9070441 60.58 µM 0.0548957531488003 0.481469070986832 no 1585 0.478110757637664 2290 6837235 SGTC_1694 st024011 44.9 µM 0.0535699532230259 0.48195261050634 no 1586 0.478638897989583 2311 2787533 SGTC_1293 1000-1278 195 µM 0.053536076397225 0.481964966253974 no 1587 0.478652393521749 2272 678847 SGTC_3158 9100007 49.47 µM 0.0533665765288032 0.482026787465214 no 1588 0.478719917657051 2266 19297233 SGTC_1979 st071809 45.3 µM 0.05302738253699 0.482150502034076 no 1589 0.478855045145763 2280 4976333 SGTC_398 bronopol 33.3 µM 0.0519471952376914 0.482544491238874 no 1590 0.479285384326826 2213 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_663 1486-0733 13.9 µM 0.0513397642150219 0.48276605409319 no 1591 0.479527391302975 2267 722445 YPR165W RHO1 SGTC_2597 laccaic acid a 100 µM 0.050525495501373 0.48306307014605 no 1592 0.479851816437546 2269 5491415 A textile dye. SGTC_85 0868-0259 160.055 µM 0.0492536007887834 0.48352703051371 no 1593 0.480358597906721 2263 83173 SGTC_1295 1013-0063 9.78 µM 0.0491342986179761 0.483570550583615 no 1594 0.480406135030974 2316 6826038 SGTC_422 cantharidin 155 µM 0.0483511262186119 0.483856247770072 no 1595 0.480718204670039 2335 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2706 st078239 82.5 µM 0.0483346174039159 0.483862270188861 no 1596 0.48072478304279 2330 15434492 SGTC_1866 st057638 64 µM 0.0481956136909508 0.483912978916068 no 1597 0.480780172947409 2273 688802 SGTC_2031 5180455 200 µM 0.044669817023368 0.485199278696231 no 1598 0.482185246099721 2331 29949 SGTC_1013 4112-3890 241 µM 0.0442842569036213 0.485339950361034 no 1599 0.482338910267231 2256 705171 SGTC_2532 xanthone 78.9 µM 0.044175959563398 0.485379462990043 no 1600 0.482382072415316 2313 7020 An insecticide. SGTC_1821 st053465 65.6 µM 0.0439852444819894 0.485449046342797 no 1601 0.482458082840891 2284 675086 SGTC_1391 3442-0225 151 µM 0.0434331257253386 0.485650492127223 no 1602 0.482678136048457 2310 5227075 SGTC_617 3770-0098 35 µM 0.0432191963413548 0.4857285472867 no 1603 0.48276340145877 2285 5962639 SGTC_2239 6685329 187.64 µM 0.0431992825801815 0.485735813131794 no 1604 0.482771338487236 2204 805680 SGTC_1888 azatryptophan 97.5 µM 0.0417207610253633 0.486275287751438 no 1605 0.483360651732099 2236 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_91 0417-1751 58.384 µM 0.0390751333863517 0.487240671504797 no 1606 0.484415243253404 2334 6795624 SGTC_3210 9128157 49.47 µM 0.0390680170986749 0.487243268326011 no 1607 0.484418080075282 2169 17590849 SGTC_574 1315-0397 40 µM 0.0386055011244792 0.487412047269052 no 1608 0.484602458150503 2336 6794277 SGTC_315 k915-0449 187 µM 0.0379077210743234 0.487666681821679 no 1609 0.48488062847416 2272 20970215 YNL149C PGA2 SGTC_1371 2421-0008 32.7 µM 0.0370016134966749 0.487997346939845 no 1610 0.485241859619308 2301 2827552 SGTC_2845 9003024 42.97 µM 0.0363003377243499 0.48825326862587 no 1611 0.485521440326764 2311 2990173 SGTC_144 4161-2749 112.381 µM 0.0361557385103536 0.488306038877391 no 1612 0.485579089223229 2328 797501 YMR168C CEP3 SGTC_2601 securinine 100 µM 0.0353841336209552 0.488587632948004 no 1613 0.485886718162964 2314 442872 A GABA receptor antagonist. SGTC_73 0327-0325 16.231 µM 0.0340899441593094 0.489059954838336 no 1614 0.486402713612127 2346 53298 SGTC_1920 st075728 45.7 µM 0.0339739331923007 0.489102294467353 no 1615 0.486448968498497 2342 3400306 SGTC_3254 9136651 49.47 µM 0.0338184532438779 0.489159038978996 no 1616 0.486510960400526 2351 16454030 SGTC_1737 st035557 69.7 µM 0.0330969366290718 0.489422369087223 no 1617 0.486798642814535 2354 5716916 SGTC_639 0833-0042 114 µM 0.0324999453956541 0.489640254970345 no 1618 0.487036679787926 2308 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1130 3454-2858 15.9 µM 0.032237584486809 0.489736010688703 no 1619 0.487141291829581 2231 715628 YIL048W NEO1 SGTC_2526 patulin 37.61 µM 0.0321385551912965 0.48977215426588 no 1620 0.487180778341812 2304 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_440 fluspirilene 35.1 µM 0.0316930481987319 0.489934755834796 no 1621 0.487358419418614 2315 3396 An atypical antipsychotic. SGTC_2220 6782180 200 µM 0.0315181424980423 0.489998593543764 no 1622 0.487428161855577 2344 833803 SGTC_3123 9126162 49.47 µM 0.0312642937324683 0.490091244630557 no 1623 0.487529382976352 2351 25239884 SGTC_2698 st077697 67.5 µM 0.0308235723221708 0.490252102766607 no 1624 0.487705120677495 2311 3154499 SGTC_1067 clotrimazole 1.36 µM 0.0305538474036017 0.490350549976218 no 1625 0.487812674692318 2324 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_561 1550-0330 72.9 µM 0.0290790428014626 0.490888850848209 no 1626 0.488400775075439 2333 6812934 SGTC_3258 9138477 49.47 µM 0.0286828979905774 0.491033445818082 no 1627 0.488558748091418 2355 4970355 SGTC_2897 9048598 12.99 µM 0.0284987205189172 0.491100671980459 no 1628 0.488632194247015 2339 6467404 SGTC_3050 9093513 49.47 µM 0.0273938100000278 0.491503977870442 no 1629 0.489072817650996 2361 25236664 SGTC_2754 granisetron 64.02 µM 0.0270002921785065 0.491647618820346 no 1630 0.489229750496335 2345 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_660 4031-1742 102 µM 0.0268690390998408 0.491695528752293 no 1631 0.489282093908416 2355 6738706 SGTC_254 nsc-64875 3.808 µM 0.0266671470816083 0.491769223507623 no 1632 0.489362608319732 2349 56993 SGTC_1841 st054148 70 µM 0.0264257146715474 0.491857351691051 no 1633 0.489458891983578 2272 675442 SGTC_188 3229-0966 278.469 µM 0.026249691852497 0.491921604174078 no 1634 0.489529090576609 2367 5722370 SGTC_1071 trifluoperazine 6.31 µM 0.0261823801927535 0.491946174573908 no 1635 0.489555934817292 2337 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_129 0088-0017 176.636 µM 0.0258772824627456 0.492057543078862 no 1636 0.489677609973362 2362 182446 SGTC_3199 9111318 49.47 µM 0.025745148941208 0.492105775399441 no 1637 0.489730306065234 2358 8548020 SGTC_605 1315-0399 119 µM 0.025263309607877 0.49228166080258 no 1638 0.48992246963773 2341 24020461 SGTC_818 4072-2707 53.5 µM 0.0245930713043457 0.492526319810065 no 1639 0.490189772963943 2366 882871 SGTC_2789 5281112 71.43 µM 0.0236199848114375 0.492881533338945 no 1640 0.490577865511678 2354 765948 SGTC_1192 1488-0095 21.4 µM 0.0229555498602366 0.49312408059229 no 1641 0.490842864834441 2324 915875 SGTC_2358 9037157 4 µM 0.0223213522368594 0.493355592296645 no 1642 0.49109580825131 2343 2388925 SGTC_1375 2910-0797 186 µM 0.0219091944712374 0.493506050304222 no 1643 0.491260195204511 2343 742508 SGTC_318 1488-0629 67.2 µM 0.0217210802772521 0.493574721614749 no 1644 0.491335224054678 2321 3662576 SGTC_3047 9092122 49.47 µM 0.020695240277425 0.493949209025625 no 1645 0.491744382958265 2355 17173831 SGTC_2677 mitomycin C 100 µM 0.0204507072291503 0.494038477691538 no 1646 0.491841916887267 2364 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2252 omeprazole 400 µM 0.0201362848031738 0.494153260449233 no 1647 0.491967327460054 2339 4594 A proton pump inhibitor. SGTC_1788 fluconazole 20 µM 0.0200817115458378 0.494173182961245 no 1648 0.49198909463832 2268 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_481 bay k-8644 50 µM 0.0199159838421587 0.494233683601644 no 1649 0.492055197205964 2357 2303 A calcium channel antagonist. SGTC_3255 9139072 49.47 µM 0.0190395100722215 0.494553651737612 no 1650 0.492404793317631 2306 17646060 SGTC_176 1486-1328 72.834 µM 0.0187023546199386 0.494676735659871 no 1651 0.492539274934581 2350 22310231 SGTC_1906 st060206 94.7 µM 0.018679368243817 0.494685127218064 no 1652 0.492548443570225 2354 5133468 SGTC_1757 st041620 31.8375 µM 0.0168766587031611 0.495343243288389 no 1653 0.493267506886175 2344 5289815 SGTC_275 trichlorophene 5.69 µM 0.0167569512169277 0.495386945428524 no 1654 0.493315256511293 2322 62616 SGTC_1248 0469-0687 58.6 µM 0.016714462498249 0.495402456985847 no 1655 0.493332204683992 2356 4017482 SGTC_1474 0330-0125 5.35 µM 0.0162979961986326 0.495554498670341 no 1656 0.493498328065906 2382 X1474 SGTC_3102 9121669 49.47 µM 0.0155174498285798 0.4958394588272 no 1657 0.493809681609451 2325 41905072 SGTC_1024 4507-0395 26 µM 0.01537295485344 0.495892210973018 no 1658 0.493867319888951 2308 4201836 SGTC_1382 3002-2117 298 µM 0.0150805853815172 0.495998949277295 no 1659 0.493983944911581 2374 1497314 SGTC_1121 fusaric acid 630.51 nM 0.0145715506868621 0.496184788442657 no 1660 0.494186998053263 2368 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_874 0599-0792 117 µM 0.0139579930171347 0.496408788112463 no 1661 0.494431747242839 2376 765305 SGTC_2505 galangin 7.89 µM 0.0138187639208987 0.49645961849302 no 1662 0.494487286259308 2369 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1311 1190-0148 100 µM 0.0137159669084359 0.496497148122578 no 1663 0.494528292447513 2377 1961333 SGTC_19 0279-0214 38.434 µM 0.0135433430943029 0.496560170527547 no 1664 0.494597152989167 2384 3566274 YBR002C RER2 SGTC_1258 0671-0043 57.1 µM 0.0130539223048582 0.496738851290762 no 1665 0.494792386368406 2363 4298767 SGTC_803 4488-1585 147 µM 0.0126178432439571 0.496898058278672 no 1666 0.49496634241094 2379 747204 SGTC_120 rhodamine 6G 52.259 µM 0.0117920642248657 0.497199541159465 no 1667 0.495295756030777 2390 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.0117335952158107 0.497220887617315 no 1668 0.49531908017691 2392 5357218 A potent inhibitor of glutathione S-transferases. SGTC_699 0375-0592 111 µM 0.0109403421823778 0.497510497227773 no 1669 0.495635522006416 2385 762578 SGTC_2004 4023728 41.89 µM 0.0107984852596033 0.497562288068282 no 1670 0.49569211138768 2383 360084 YDR527W RBA50 SGTC_2717 st081029 62.2815 µM 0.0103266284979724 0.497734559530617 no 1671 0.49588034449779 2382 5292846 SGTC_1729 st035615 45.989 µM 0.0096404189657509 0.497985090371392 no 1672 0.496154088845546 2273 17385451 SGTC_1548 st061468 90.8 µM 0.00744386108443468 0.49878704487488 no 1673 0.497030356509196 2392 390799 SGTC_1220 1838-0075 193 µM 0.00731986950944492 0.498832313879892 no 1674 0.497079820643124 2386 5529645 SGTC_1506 4226-2149 212 µM 0.00657984857388663 0.499102493912052 no 1675 0.497375039146272 2357 991114 SGTC_2110 5483698 200 µM 0.00618126180558553 0.499248017251694 no 1676 0.497534049022706 2386 2848765 YHR062C RPP1 SGTC_2771 fluoxetine 41.05 µM 0.00479102776347148 0.499755589953129 no 1677 0.498088663770695 2394 3386 A selective serotonin reuptake inhibitor. SGTC_2869 9037858 32.47 µM 0.00474077968130122 0.499773935477126 no 1678 0.49810870962752 2397 27187042 SGTC_1673 st016611 27.3 µM 0.00350240596621353 0.499773935477126 no 1679 0.4986027450336 2394 5226799 SGTC_2551 apiole 73.87 µM 0.00204703721435189 0.499242582167797 no 1680 0.499183350875982 2399 10659 A possible DNA adduct former. SGTC_1161 k007-0610 110 µM 0.00153587939541975 0.499055959358484 no 1681 0.499387273012466 2400 5843850 SGTC_987 1497-1013 404 µM 0.00128887241119949 0.498965777619981 no 1682 0.49948581444349 2403 1676435 SGTC_1454 4239-0054 42.6 µM 0.00127214538793341 0.498959670620279 no 1683 0.499492487554825 2402 1340767 SGTC_920 mycophenolic acid 780.421 nM 0.00110360642515421 0.498898137426508 no 1684 0.499559724825455 2399 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_69 0096-0274 206.684 µM 0.000319330596935655 0.498611800465329 no 1685 0.499872605525622 2405 6741392 SGTC_372 0155-0182 15.9 µM 0.000166487120718869 0.498555997808593 no 1686 0.49993358124871 2379 771486 SGTC_1331 1472-0049 76.2 µM 7.61462859993291e-05 0.498523014676477 no 1687 0.499969622027049 2404 24051409 SGTC_507 nimesulide 162 µM 0 0.49849521393375 no 1688 0.5 2405 4495 A COX2 inhibitor. SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0 0.49849521393375 no 1689 0.5 2405 16486 A toxic proline analog. SGTC_2703 st077852 53.4 µM 0 0.49849521393375 no 1690 0.5 2406 6281836 SGTC_1685 st024049 53.0905 µM -0.000429578342652837 0.498338376523939 no 1691 0.499828623041642 2406 1941139 SGTC_1446 4239-0190 62 µM -0.000523919517026251 0.498303932955568 no 1692 0.499790986362693 2408 1340085 SGTC_1972 st070201 17.4 µM -0.00115132650171533 0.498074869622258 no 1693 0.499540687281393 2409 2829099 SGTC_2104 5389443 200 µM -0.00169476825697165 0.497876462108744 no 1694 0.499323885610472 2409 2244536 SGTC_2873 9040596 71.43 µM -0.00265891064336693 0.497524460496164 no 1695 0.498939249374435 2426 6463863 SGTC_1442 4112-3290 3 µM -0.00373932882993237 0.497130009708776 no 1696 0.498508227105889 2412 704353 SGTC_2268 7933382 153.85 µM -0.00557278376157834 0.496460638726467 no 1697 0.49777679244527 2414 935025 YOR257W CDC31 SGTC_1749 st037932 54.2 µM -0.00572056426316189 0.496406686361295 no 1698 0.497717837494918 2430 594497 SGTC_1484 3473-2379 286 µM -0.00745645825805071 0.495772943617889 no 1699 0.497025331103496 2421 671917 SGTC_951 1171-0579 82.7 µM -0.00757718745048822 0.495728868004321 no 1700 0.49697716848486 2413 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1600 coumarin 106 71.1 µM -0.00771702375051392 0.495677816864773 no 1701 0.496921383503617 2479 100336 A hepatotoxic, DNA x-linker. SGTC_3107 9121808 49.47 µM -0.00872154515530861 0.495311090454056 no 1702 0.496520650996823 2419 662681 SGTC_886 0866-0150 153 µM -0.00886605510979069 0.495258333692004 no 1703 0.496463002095156 2419 271463 SGTC_595 3909-8003 73.7 µM -0.00955747449333399 0.495005915927025 no 1704 0.496187177378089 2432 699517 SGTC_3236 9132701 49.47 µM -0.0105673566910647 0.494637239968887 no 1705 0.495784313084274 2428 24282524 SGTC_311 1315-0136 58 µM -0.012450140601666 0.493949907755154 no 1706 0.495033240830297 2432 6759207 SGTC_159 3970-0959 50 µM -0.0126318138488419 0.493883586736205 no 1707 0.494960769390118 2443 6615653 SGTC_690 glyoxal 20.3 µM -0.0129174462355118 0.493779315089231 no 1708 0.494846827852316 2432 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1550 gossypolone 36.6 µM -0.0131139805918494 0.493707569406328 no 1709 0.494768428629188 2440 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2728 chlorpromazine 9.18 µM -0.0145790137306511 0.493172759546528 no 1710 0.494184021045788 2437 2726 A thorazine and dopamine antagonist. SGTC_2098 5376439 882.5 nM -0.015774148299653 0.492736485114766 no 1711 0.493707286269804 2460 2844116 SGTC_1518 st038567 90.8 µM -0.0164948604292713 0.492473399012214 no 1712 0.493419801157341 2431 77966 SGTC_1942 st076330 65.2 µM -0.0166331625045482 0.492422914102689 no 1713 0.493364634180593 2477 24208414 SGTC_1447 4239-0816 81.9 µM -0.0194796162855149 0.491383890853431 no 1714 0.492229248903129 2446 1341554 SGTC_2982 9019404 25.97 µM -0.0195864732915748 0.491344886602219 no 1715 0.492186627257179 2455 22333232 SGTC_3160 9100216 49.47 µM -0.0197897581912293 0.491270685095564 no 1716 0.492105544032219 2443 17191039 SGTC_2508 celastrol 40.54 µM -0.0201667852615309 0.491133066345931 no 1717 0.491955162007995 2436 122724 Celastrol is a natural product and antioxidant. SGTC_1523 st012844 44.7 µM -0.0211760291887528 0.490764687195075 no 1718 0.491552617965415 2508 4274103 SGTC_3203 9113543 49.47 µM -0.0218083544503534 0.490533889262132 no 1719 0.491300414942617 2500 17018012 SGTC_2066 5222451 176 µM -0.0221389221813342 0.490413233708682 no 1720 0.491168569332854 2449 2281147 SGTC_1493 4348-0038 111 µM -0.0242628688069821 0.48963802531098 no 1721 0.490321465402642 2453 800424 SGTC_3187 9109394 49.47 µM -0.0252922029706854 0.489262347808113 no 1722 0.489910946535701 2481 17098090 SGTC_966 1300-0360 30.2 µM -0.0254099974657404 0.489219356790719 no 1723 0.489863968429582 2464 70588 SGTC_869 0564-0080 44.1 µM -0.0262695498656955 0.488905652981514 no 1724 0.489521171106515 2493 6843321 SGTC_2971 9092186 9.93 µM -0.0270737835194779 0.488612144613878 no 1725 0.48920044240727 2466 25236400 SGTC_2326 6164455 177.58 µM -0.0272320483569288 0.488554385934124 no 1726 0.489137327143302 2488 2888790 SGTC_2515 chrysin 20.77 µM -0.0272474362674986 0.488548770136012 no 1727 0.489131190532285 2467 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_3014 9081533 49.47 µM -0.0275713174647653 0.488430570639394 no 1728 0.489002029156334 2466 21367265 SGTC_1810 st050138 53 µM -0.0288301919287785 0.487971157827462 no 1729 0.488500010603054 2455 3444541 SGTC_794 k038-0031 316 µM -0.0295397534668427 0.487712217904891 no 1730 0.488217057041206 2446 6624242 SGTC_1921 5740136 50 µM -0.0305936362201614 0.487327634613189 no 1731 0.487796808668251 2460 1774243 SGTC_1691 st019933 84.6 µM -0.0309570038124609 0.487195037088273 no 1732 0.487651914605457 2455 6176082 SGTC_813 k007-0158 173 µM -0.0312651038247067 0.487082608525116 no 1733 0.48752905995422 2503 6523916 SGTC_1132 3456-3614 2.5 µM -0.0320635020161263 0.4867912703904 no 1734 0.487210704803435 2494 3125502 SGTC_1350 1495-0454 146 µM -0.0327523610810627 0.486539909103572 no 1735 0.486936034080265 2480 1069057 SGTC_2279 7948423 32.93 µM -0.0342757020496397 0.485984068602778 no 1736 0.486328650218761 2458 1247112 SGTC_493 zm226600 134 µM -0.0348941982975696 0.485758397840537 no 1737 0.486082053442747 2537 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1082 camptothecin 424.86 nM -0.035930918656402 0.485380139888617 no 1738 0.485668721127973 2457 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2158 5657123 3.6195 µM -0.0364285998993402 0.485198560484867 no 1739 0.485470304943465 2466 2858827 SGTC_375 3970-0961 9.27 µM -0.036917118172555 0.485020327182645 no 1740 0.485275545361454 2493 2898222 SGTC_2752 diclazuril 33.15 µM -0.0373568679805881 0.484859889354858 no 1741 0.485100231505935 2492 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2159 5658611 73.75 µM -0.0379361498822633 0.484648548539225 no 1742 0.48486929517268 2472 793844 SGTC_365 0121-0052 13.6 µM -0.0379658146440451 0.484637725988086 no 1743 0.484857469164399 2500 3101739 SGTC_1744 st037937 38.9 µM -0.038339771838765 0.48450129671134 no 1744 0.48470839037093 2523 1016152 SGTC_2372 9071633 200 µM -0.0383528462532967 0.484496526858794 no 1745 0.484703178267632 2472 21321366 SGTC_432 NS 1619 61.3 µM -0.039594075417511 0.484043707597307 no 1746 0.484208375434427 2608 4552 A K+/calcium channel activator. SGTC_1998 st075797 76.8 µM -0.0408376146431679 0.48359006622625 no 1747 0.483712676104788 2462 24208315 SGTC_2481 5478948 45.16 µM -0.0408484125007261 0.483586127275082 no 1748 0.483708371974339 2535 77792 SGTC_2112 5488546 200 µM -0.0408671619419552 0.483579287668989 no 1749 0.48370089827025 2473 600757 SGTC_2306 7482397 179.52 µM -0.0409399593348318 0.48355273196385 no 1750 0.483671880597244 2487 891448 SGTC_1006 4099-6547 255 µM -0.0418252297926266 0.483229800705622 no 1751 0.483319011070855 2528 3146833 SGTC_2801 7907800 81.82 µM -0.0422775620394474 0.483064802006364 no 1752 0.483138716094435 2514 6620925 SGTC_337 1315-0038 354 µM -0.0426454143801775 0.482930621453259 no 1753 0.482992096479163 2500 1626437 SGTC_2102 5377816 72.7585 µM -0.0427332363389166 0.482898587148344 no 1754 0.482957092496474 2527 1379702 SGTC_762 1165-0429 115 µM -0.0429236947374515 0.482829115126062 no 1755 0.48288118024276 2454 5967793 SGTC_367 0335-0881 7.1 µM -0.0436464026844434 0.482565503353978 no 1756 0.482593131462461 2496 23828853 SGTC_2911 7942208 15.64 µM -0.0441771858990302 0.482371902051138 no 1757 0.48238158365534 2517 1243384 SGTC_1383 3049-0032 20.7 µM -0.0443499816016831 0.482308876323574 no 1758 0.48231271564216 2511 712864 SGTC_1514 1189-1591 158 µM -0.0455262700464461 0.481879847188079 no 1759 0.481843918066805 2496 767698 YMR146C TIF34 SGTC_2962 9082311 13.18 µM -0.0456382093822396 0.481839020501728 no 1760 0.481799307102028 2510 16459453 SGTC_3308 9128332 17.569 µM -0.0457084801801975 0.481813391325731 no 1761 0.481771302334624 2507 17332805 YDL196W YDL196W SGTC_131 0141-0277 33.849 µM -0.0458026032771377 0.481779062853444 no 1762 0.481733791937578 2526 1547771 SGTC_2647 atorvastatin 60.16 µM -0.0461833951994724 0.481640182224344 no 1763 0.481582038531788 2538 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_977 1348-1378 135 µM -0.0468885959971724 0.481382990621012 no 1764 0.481301008587104 2485 X977 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.0468956979222614 0.481380400539094 no 1765 0.48129817844219 2544 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1195 1502-0147 41.1 µM -0.0472862328617047 0.481237973118654 no 1766 0.481142550196969 2476 817940 SGTC_1212 0520-0165 585 µM -0.0475026241509681 0.481159056617746 no 1767 0.481056319464254 2562 5403258 SGTC_1628 st004252 77.7 µM -0.0475388393331289 0.481145849247539 no 1768 0.481041888000811 2523 692968 SGTC_2413 inermin 26.06 µM -0.0476903342016106 0.481090600576626 no 1769 0.480981518764392 2551 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2007 4011539 71.82 µM -0.0477786308876643 0.481058399821384 no 1770 0.48094633359209 2496 45595301 SGTC_3066 9117245 49.47 µM -0.0478318850631927 0.481038978714273 no 1771 0.480925112512446 2511 17176980 SGTC_1100 amiodarone 5.07 µM -0.0489694146016585 0.480624147267248 no 1772 0.480471835148786 2496 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2142 5622915 118.518 µM -0.0495241364207421 0.480421860274938 no 1773 0.480250801357236 2520 5322196 SGTC_2476 5806916 10.51 µM -0.0501382591190292 0.480197917812077 no 1774 0.48000610584767 2524 2870194 SGTC_3084 9116877 49.47 µM -0.0508999794855666 0.479920161920826 no 1775 0.4797026109292 2485 27241325 SGTC_1168 k815-0004 80.5 µM -0.0515304529283154 0.479690271651557 no 1776 0.479451418075719 2489 642433 SGTC_2954 9074818 52.69 µM -0.0516142188816011 0.479659728480726 no 1777 0.479418044706501 2548 16648742 SGTC_1605 st000082 49.1 µM -0.051707742841728 0.47962562743659 no 1778 0.479380783799794 2616 1114022 SGTC_3201 9113999 49.47 µM -0.0533082193769601 0.479042079221186 no 1779 0.478743165699828 2592 16649224 SGTC_2203 7227154 166.4 µM -0.0536377626818013 0.478921930288569 no 1780 0.478611884766904 2509 896304 SGTC_2244 6635614 200 µM -0.0536718266280325 0.478909510947054 no 1781 0.478598314765491 2506 836499 SGTC_3124 9127567 49.47 µM -0.0539395760009646 0.478811893173749 no 1782 0.478491652728348 2509 17592030 SGTC_134 0269-0018 6.916 µM -0.0540650932709786 0.478766131724477 no 1783 0.478441651543663 2553 4378915 SGTC_1242 0402-0103 60.1 µM -0.0543112969740272 0.47867637088003 no 1784 0.478343574577594 2503 432868 SGTC_1655 st012546 55.1 µM -0.055228512496411 0.478341982379516 no 1785 0.477978206953824 2567 720985 YLR208W SEC13 SGTC_3288 9119690 36.221 µM -0.0552517503488421 0.478333510771996 no 1786 0.477968950525629 2541 17595618 YKL019W RAM2 SGTC_1255 0566-0045 221 µM -0.0555368521021686 0.478229574678025 no 1787 0.477855385754502 2577 2788469 SGTC_1910 st062352 60.4 µM -0.0565744180539466 0.477851334373988 no 1788 0.477442106666327 2497 2245730 SGTC_414 piperonyl butoxide 100 µM -0.0576760707685207 0.477449753353705 no 1789 0.477003327359549 2504 5794 A potent inhibitor of cytochrome P450. SGTC_61 0978-8327 98.565 µM -0.058430906033218 0.477174609493968 no 1790 0.476702698682431 2514 6150059 YHR072W ERG7 SGTC_1940 st075990 51.1 µM -0.058479840972494 0.477156772667465 no 1791 0.476683209791696 2725 1084979 SGTC_1191 1487-1166 10.6 µM -0.0585786101467129 0.477120771359873 no 1792 0.476643874025532 2607 3955771 SGTC_2141 5621638 7.665 µM -0.0586897534964084 0.477080259895686 no 1793 0.476599610398062 2594 2856238 SGTC_1199 1638-0010 4.46 µM -0.0609018628189571 0.476274001575509 no 1794 0.475718682943426 2518 3111136 SGTC_1949 st076024 69.1 µM -0.0612224177010507 0.47615717534644 no 1795 0.475591038237339 2491 2921930 SGTC_2943 9068529 45.32 µM -0.061325737100543 0.476119521026821 no 1796 0.475549897065575 2499 3270634 SGTC_3017 9080681 49.47 µM -0.0619011926835226 0.475909802576204 no 1797 0.475320758848653 2576 16451914 SGTC_907 3448-6986 75.5 µM -0.0619787151695977 0.475881550868557 no 1798 0.475289891121026 2554 590582 SGTC_2008 4012253 172 µM -0.0629309609800107 0.47553453155337 no 1799 0.474910740201096 2542 603940 SGTC_1656 st012921 11 µM -0.0632342829034345 0.475423998258206 no 1800 0.474789972792896 2552 6732821 SGTC_1564 D-Arginine 115 µM -0.0642876307509762 0.475040163369513 no 1801 0.474370601156124 2548 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_528 3492-0019 172 µM -0.064653337204446 0.474906907096185 no 1802 0.474225008279324 2513 2869262 SGTC_3122 9126309 49.47 µM -0.0649616042801176 0.474794582787536 no 1803 0.474102285498808 2520 17591206 SGTC_2254 7938975 95.19 µM -0.0651784047149597 0.47471558768511 no 1804 0.474015977551135 2594 2969277 SGTC_421 streptovitacin 30 mM -0.0654227036202448 0.474626574216161 no 1805 0.473918723962752 2713 91467 include heat shock SGTC_662 k832-1615 104 µM -0.065651095969553 0.474543357652303 no 1806 0.473827804062459 2577 5878478 SGTC_892 0929-0076 29 µM -0.0658520284769913 0.474470147217867 no 1807 0.473747816680323 2529 5751038 SGTC_3143 9086658 49.47 µM -0.066058107953338 0.474395062363536 no 1808 0.473665781487873 2597 25236626 SGTC_162 k030-0015 37.8 µM -0.0661199066084406 0.474372546261528 no 1809 0.473641181174285 2564 1809920 YMR134W ERG29 SGTC_442 cape 100 µM -0.0667614744032893 0.474138798355499 no 1810 0.473385796961686 2521 5281787 SGTC_992 3909-8734 162 µM -0.067851045478641 0.47374184600704 no 1811 0.472952104469261 2551 4288319 SGTC_2346 9031566 143.75 µM -0.0681992239114819 0.473615003177518 no 1812 0.472813522381882 2604 4771086 SGTC_3243 9134147 49.47 µM -0.0691720485145472 0.473260613408308 no 1813 0.472426335927564 2527 24282180 SGTC_1453 4237-0541 195 µM -0.0697235115802999 0.473059730595089 no 1814 0.472206863892164 2527 739892 SGTC_1662 st014054 52 µM -0.0706912824646184 0.472707214897252 no 1815 0.471821729533029 2515 2838777 SGTC_934 2950-0684 338 µM -0.0710239001383976 0.472586062060354 no 1816 0.471689366980625 2614 1121253 SGTC_3060 1327-0027 12.5 µM -0.0725817923862641 0.472018648506873 no 1817 0.471069458035026 2580 16000455 YPR107C YTH1 SGTC_2054 5233173 129 µM -0.0727255868307344 0.471966278720325 no 1818 0.471012243555928 2607 6889 SGTC_2679 rapamycin 1 nM -0.0728277461510267 0.471929072696969 no 1819 0.470971595671009 2570 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_909 3448-9333 149 µM -0.0730723390907003 0.471839993904607 no 1820 0.470874276503083 2534 3344074 SGTC_2175 5807670 165.306 µM -0.0744902633059705 0.471323625138337 no 1821 0.470310144199878 2543 241186 SGTC_2255 7941087 197.44 µM -0.0749765727004194 0.471146535770508 no 1822 0.470116675846521 2528 935561 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.0756014436010972 0.470918997666521 no 1823 0.469868093962921 2569 1273210 SGTC_1786 berberine 21.6 µM -0.0758955633076129 0.470811901320863 no 1824 0.469751093324097 2530 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1843 st055809 45.5 µM -0.0761459503195944 0.470720730806892 no 1825 0.469651491582011 2654 16413835 SGTC_1096 rimcazole 32.2 µM -0.076169639583058 0.470712105189971 no 1826 0.46964206830045 2527 18528119 A dopamine reuptake inhibitor. SGTC_1412 3909-8563 178 µM -0.0782744762344884 0.469945757846656 no 1827 0.468804860085428 2550 23767530 SGTC_556 4058-0063 51.5 µM -0.0790817330033012 0.469651874115901 no 1828 0.468483806477407 2555 6615692 SGTC_415 dibenzyl ketone 100 µM -0.0805613674471042 0.469113252741948 no 1829 0.467895395305759 2649 7593 SGTC_669 0108-0021 26.2 µM -0.0817855137890975 0.468667677665115 no 1830 0.467408637900696 2515 17201 SGTC_3061 glucosamine 200 µM -0.0827732774258706 0.468308171734612 no 1831 0.467015908859278 2524 91431 and experimental redox chemotherapeutic SGTC_287 k060-0039 29.6 µM -0.0832773429961656 0.468124722236889 no 1832 0.466815507687856 2608 5861974 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.0849827297593661 0.467504114621559 no 1833 0.466137560344986 2528 5711223 A potent inhibitor of glutathione S-transferases. SGTC_272 doxorubicin 8.13 µM -0.0854210760830672 0.467344608628238 no 1834 0.465963319054062 2531 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2639 lactacystin 53 µM -0.0858833428342255 0.467176404121664 no 1835 0.465779576536707 2617 3870 A proteasome inhibitor. SGTC_1433 4060-0023 7.6 µM -0.0873420789226337 0.466645653958576 no 1836 0.465199803828196 2645 3840627 SGTC_2881 9058953 51.95 µM -0.0877223698720809 0.466507297662246 no 1837 0.465048669787186 2553 17122249 SGTC_1916 st067606 49.2 µM -0.0880245936102835 0.466397346426691 no 1838 0.464928564567816 2653 19590279 SGTC_733 4069-0007 56.1 µM -0.0884461424636131 0.466243988115011 no 1839 0.464761044291999 2565 5717425 YNL287W SEC21 SGTC_2170 morpholine 200 µM -0.0892959616349939 0.465934841500981 no 1840 0.464423351699399 2644 121171 Reacts with secondary amines. SGTC_339 3091-4833 71.4 µM -0.0893046484748856 0.465931681514352 no 1841 0.464419899942254 2576 3240077 SGTC_2080 5212524 12.4 µM -0.0914445137813524 0.465153334826039 no 1842 0.463569696503774 2577 260183 SGTC_15 0266-0086 27.098 µM -0.0919186169844309 0.464980904215688 no 1843 0.463381349932718 2585 1712902 YIL048W NEO1 SGTC_1388 3346-4487 254 µM -0.0946179963479106 0.463999270328875 no 1844 0.462309127474063 2636 3345614 SGTC_1867 st057372 64 µM -0.0947389571220102 0.463955287822954 no 1845 0.462261086908435 2564 688837 SGTC_2711 st079103 59.1 µM -0.0952734271425189 0.463760954641152 no 1846 0.462048824346773 2660 54693780 SGTC_2399 5884133 200 µM -0.0956073394525161 0.463639548584084 no 1847 0.461916217933466 2613 722445 SGTC_546 peri-Naphthalide 147 µM -0.0965034709295475 0.463313743913927 no 1848 0.461560358695682 2664 223824 A penicillin ester. SGTC_559 1550-0661 158 µM -0.0977961314214957 0.462843817409946 no 1849 0.461047089668952 2649 5830875 SGTC_407 eburnamonine 100 µM -0.0978693189736459 0.462817212764814 no 1850 0.461018031454887 2571 3195 SGTC_884 0851-0618 334 µM -0.0984993166623933 0.462588207146228 no 1851 0.460767907273269 2646 9642473 SGTC_1844 rapamycin 4 nM -0.101363358396356 0.461547278786775 no 1852 0.459631011192075 2585 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_562 3772-2733 112 µM -0.101773158998867 0.461398359217689 no 1853 0.459468365509168 2605 2876874 YIL048W NEO1 SGTC_2487 5918373 44.05 µM -0.102180704325465 0.461250264572822 no 1854 0.459306621649618 2569 2876279 SGTC_1980 st071811 45.7 µM -0.10280972810579 0.461021699193991 no 1855 0.459056992134706 2741 4974850 SGTC_2694 st077685 81.9 µM -0.103697388576352 0.460699176154149 no 1856 0.458704749548861 2591 2838096 SGTC_759 3486-0358 89.3 µM -0.103772817081147 0.46067177110878 no 1857 0.458674819401899 2584 875103 SGTC_3257 9139206 32.98 µM -0.104085477258536 0.46055817591006 no 1858 0.458550757861696 2666 4910041 SGTC_1266 0828-0227 32.9 µM -0.104598525871058 0.460371782882027 no 1859 0.458347192237355 2680 3913820 SGTC_1868 st057644 42.7 µM -0.105177388063939 0.460161489920389 no 1860 0.458117526450474 2582 688665 SGTC_740 k014-0057 261 µM -0.106126709684352 0.459816638108348 no 1861 0.457740909773705 2699 4012779 SGTC_1946 st076057 65.1 µM -0.106476107677744 0.459689722933048 no 1862 0.457602305472195 2592 953009 SGTC_1019 4262-0212 3.4 µM -0.106619102335555 0.45963778279945 no 1863 0.45754558174788 2589 4677213 SGTC_172 1112-0046 2.638 µM -0.106790686892152 0.459575458829411 no 1864 0.457477518003407 2648 2802135 YIL048W NEO1 SGTC_933 2914-0560 114 µM -0.106839654686538 0.459557672636064 no 1865 0.457458093806523 2620 463887 SGTC_1134 3477-0009 42.5 µM -0.107383772801901 0.459360042274629 no 1866 0.457242263745802 2790 3973534 SGTC_1956 st077085 54 µM -0.109629427279606 0.458544499858111 no 1867 0.456351635861 2638 24208685 SGTC_1612 st002233 45.4 µM -0.110964029980503 0.458059901712506 no 1868 0.455822435225279 2601 1035021 SGTC_2934 9036370 36.88 µM -0.112102898716164 0.457646424406545 no 1869 0.455370909536325 2694 6462800 SGTC_39 0986-0283 58.349 µM -0.112833696169527 0.457381125439836 no 1870 0.455081201621364 2668 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1624 st003710 6.25 µM -0.113435193113696 0.457162780249153 no 1871 0.454842769847562 2653 24207033 SGTC_2492 derrusnin 100 µM -0.1141224680883 0.456913313208427 no 1872 0.454570355810907 2589 1715307 Part of coumarin class of compounds. SGTC_1977 st070720 65.3 µM -0.114184759834374 0.456890703390843 no 1873 0.454545666389394 2713 682188 SGTC_1654 st012436 41.8 µM -0.114310678046729 0.456844999723179 no 1874 0.454495759064502 2610 4323132 SGTC_820 1582-0060 59.9 µM -0.114393591407616 0.456814905542383 no 1875 0.454462896982215 2642 3848840 SGTC_928 2764-0428 58.7 µM -0.11463241876979 0.456728222299501 no 1876 0.454368241309714 2735 662578 SGTC_1891 st059073 26.2 µM -0.115587162799394 0.456381715158105 no 1877 0.453989868654597 2667 688754 SGTC_1455 4262-0120 131 µM -0.116311598435418 0.456118816414939 no 1878 0.453702796890265 2809 1529587 SGTC_810 3825-7150 143 µM -0.116348636982118 0.456105375587821 no 1879 0.45368812029169 2621 22330411 YGL099W LSG1 SGTC_1679 SEC14.276 6.7 µM -0.116388927392106 0.456090754757072 no 1880 0.453672155207572 2771 1005053 YMR079W SEC14 SGTC_783 0848-0141 92.7 µM -0.116403350143816 0.456085520955045 no 1881 0.453666440207123 2603 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2163 5671233 125 µM -0.117458520871511 0.455702635925429 no 1882 0.453248356002286 2656 701023 SGTC_3079 9117512 49.47 µM -0.11996468662287 0.454793400426001 no 1883 0.452255560938942 2586 7185044 SGTC_2375 9072683 200 µM -0.120775746974221 0.454499198681663 no 1884 0.451934330285209 2611 16798029 SGTC_903 1134-0042 114 µM -0.120848514722626 0.454472804331594 no 1885 0.451905511238237 2631 701009 SGTC_3244 9134489 49.47 µM -0.121787019691672 0.454132407448589 no 1886 0.451533847104184 2704 16584271 SGTC_2744 captopril 92.04 µM -0.122390053543393 0.453913704105112 no 1887 0.451295057706917 2649 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2930 9013230 14.89 µM -0.122718133636504 0.453794724588048 no 1888 0.451165151919657 2694 2995857 SGTC_2389 9091542 195.52 µM -0.122944998911247 0.453712453441533 no 1889 0.451075325960968 2690 3626624 YOL127W RPL25 SGTC_2386 9075165 157.42 µM -0.123375387954005 0.45355638124827 no 1890 0.450904922863336 2615 16452277 SGTC_850 0388-0143 75.9 µM -0.123612286145535 0.453470477797933 no 1891 0.450811132081376 2643 67273 SGTC_1712 st032288 53.4 µM -0.125067044886682 0.452943004578219 no 1892 0.450235236388247 2652 2883011 SGTC_263 alizarin 107.927 µM -0.125099160946857 0.452931360720341 no 1893 0.450222523773376 2608 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_101 0490-5701 117.494 µM -0.125792424747871 0.45268002392073 no 1894 0.449948119157995 2615 4661669 SGTC_535 2293-4129 48.2 µM -0.125957317624186 0.452620246220611 no 1895 0.449882855505844 2686 396118 YIL048W NEO1 SGTC_2434 5670830 169.91 µM -0.126308533936689 0.452492925299565 no 1896 0.449743850629679 2721 1549830 SGTC_1369 1866-0067 208 µM -0.128181274855233 0.451814112795532 no 1897 0.449002759159854 2647 3531355 SGTC_941 3237-0776 460 µM -0.130078316726876 0.451126635534439 no 1898 0.448252232547821 2764 760008 SGTC_3350 9150499 3.57 µM -0.130375903068674 0.451018805172109 no 1899 0.4481345152086 2643 4910996 YPR165W RHO1 SGTC_395 anisomycin 6.25 µM -0.130510586269614 0.45097000392394 no 1900 0.448081239573077 2677 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3153 9100258 49.47 µM -0.130781262131953 0.450871929198531 no 1901 0.447974173161581 2670 25236848 SGTC_502 l-744,832 89.3 µM -0.131229937368018 0.450709366082556 no 1902 0.447796707072005 2708 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_320 4092-0846 5.34 µM -0.131645238714406 0.45055890229557 no 1903 0.447632450785185 2733 1359356 SGTC_1825 st052143 62.6 µM -0.13210171514385 0.450393528962843 no 1904 0.447451919657255 2755 674173 SGTC_1117 retinoic acid 1.10837 µM -0.13257645327904 0.450221548873812 no 1905 0.447264177785152 2749 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_111 0083-0039 52.457 µM -0.133107474223188 0.450029190678937 no 1906 0.447054192086889 2627 759313 SGTC_2868 9035608 32.47 µM -0.13362710236337 0.449840970802704 no 1907 0.446848725900007 2607 6462614 SGTC_2960 9079389 5.97 µM -0.133818298455047 0.449771718528746 no 1908 0.446773128632051 2720 16457355 SGTC_1163 k060-0048 49.9 µM -0.135192913567272 0.449273870549097 no 1909 0.446229674905608 2646 6809982 SGTC_760 0568-0725 82.9 µM -0.136093002769642 0.448947926078341 no 1910 0.445873879522248 2806 3916171 SGTC_248 streptozotocin 5.23457 mM -0.137265394004629 0.448523426028221 no 1911 0.445410511528348 2748 5300 DNA alkylating agent. SGTC_2692 st077426 47.7 µM -0.13775703517431 0.448345429838325 no 1912 0.445216220746897 2729 25238571 SGTC_2688 kanamycin b 96.69 µM -0.137794397934048 0.448331903265514 no 1913 0.4452014559631 2737 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_656 4090-1979 187 µM -0.138515981617993 0.448070677559084 no 1914 0.444916319930195 2696 22330961 SGTC_845 0330-0138 4.51 µM -0.138740627120634 0.447989356613794 no 1915 0.444827556372694 2657 9039800 SGTC_861 0443-0273 110 µM -0.139393591646126 0.447752997990115 no 1916 0.444569568024649 2734 6149169 SGTC_2199 6590217 200 µM -0.139941919348857 0.447554529892935 no 1917 0.444352940149709 2691 703109 SGTC_2431 5490079 200 µM -0.140288049316275 0.44742925434957 no 1918 0.444216203106283 2703 5722345 SGTC_553 k007-0256 45.7 µM -0.142302787937097 0.446700160284762 no 1919 0.443420422241352 2712 6287000 SGTC_1291 0993-0025 5.79 µM -0.14337395667727 0.446312598684951 no 1920 0.442997425010935 2766 4353356 SGTC_2223 6903751 107.57 µM -0.144263593615568 0.445990756416927 no 1921 0.442646162808716 2760 5598863 SGTC_980 1473-0395 201 µM -0.144595577222474 0.445870664442186 no 1922 0.442515094700173 2666 768876 SGTC_1991 st073000 8.92 µM -0.1452519967526 0.445633225423606 no 1923 0.442255956863163 2857 4301969 YIL048W NEO1 SGTC_1803 st050068 52.4 µM -0.145704110441339 0.445469698920401 no 1924 0.442077488169823 2667 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1861 st057647 17.4 µM -0.145943610600115 0.445383077068825 no 1925 0.441982951930574 2859 688668 SGTC_1286 0929-0070 131 µM -0.146266002118877 0.44526647938396 no 1926 0.441855701777413 2777 1420408 SGTC_2831 7999036 19.48 µM -0.147607164629713 0.444781478954956 no 1927 0.441326400243986 2944 2988270 SGTC_2979 9012552 45.46 µM -0.148351075510134 0.444512496367622 no 1928 0.441032854413827 2733 17100905 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.150966613316732 0.443566976363222 no 1929 0.440001026356737 2704 676296 Flavone; oxidizing agent. SGTC_1260 0700-1617 7.75 µM -0.15227017701941 0.443095856138276 no 1930 0.439486922947037 2760 2853078 SGTC_6 0844-0013 19.835 µM -0.152795149719997 0.442906148731688 no 1931 0.439279911392394 2714 1584900 SGTC_1945 st075991 56.6 µM -0.153590116120202 0.442618899649122 no 1932 0.438966465328725 2733 1084980 SGTC_2278 7948257 134.34 µM -0.155173830482085 0.442046738464345 no 1933 0.438342139310548 2724 1247028 SGTC_153 4077-0274 519.67 µM -0.15679270354978 0.441462000155985 no 1934 0.437704111725353 2771 3121976 SGTC_2514 salinomycin 42.74 µM -0.157782066822881 0.441104704034219 no 1935 0.437314265119285 2829 23682228 A polyether potassium ionophore. SGTC_2036 5160441 105 µM -0.158384033678896 0.44088733469862 no 1936 0.437077097128 2725 134534 YIL048W NEO1 SGTC_2806 7952793 58.44 µM -0.160689856895227 0.440054870684924 no 1937 0.436168839319962 2827 2972490 SGTC_113 0099-0221 2.5 µM -0.162170393855539 0.439520496571979 no 1938 0.435585836719319 2708 89219 SGTC_1805 st050013 60.3 µM -0.162459675268656 0.439416098304854 no 1939 0.435471940424442 2760 4037144 SGTC_918 glabranin 770.725 nM -0.162562882790764 0.439378852940713 no 1940 0.435431306705104 2740 124049 Also referred to as licorice root. SGTC_1180 1193-0155 285 µM -0.163040736287881 0.439206412940646 no 1941 0.435243180425555 2826 2921347 SGTC_1614 st002383 48.6 µM -0.163945676173664 0.438879884584756 no 1942 0.43488695457681 2708 1947235 SGTC_1881 5652484 16 µM -0.165011555865926 0.438495337874977 no 1943 0.434467443239005 2784 2255129 SGTC_2076 5212012 200 µM -0.166013094189254 0.438134057061186 no 1944 0.434073322746306 2648 604802 SGTC_2393 9031399 185.94 µM -0.168195769680819 0.4373468884901 no 1945 0.433214634421491 2844 1526623 YDL150W RPC53 SGTC_2083 5306046 65.942 µM -0.171175614769932 0.436272626461077 no 1946 0.432042840540713 2745 539837 SGTC_625 k213-0058 121 µM -0.174392147165747 0.435113564018293 no 1947 0.430778642707122 2765 3655420 SGTC_1671 st016596 74.5 µM -0.174683971571917 0.435008433881318 no 1948 0.430663981475501 2746 2829167 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.178180842477721 0.433749040855403 no 1949 0.429290477229765 2860 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1416 3966-0321 25.3 µM -0.178820905604054 0.433518595454808 no 1950 0.429039164782295 2774 582530 YLR208W SEC13 SGTC_2835 9006588 71.43 µM -0.179382447065756 0.433316439242924 no 1951 0.428818706526407 2958 2345538 SGTC_1010 4112-3296 15.2 µM -0.179637380784128 0.433224668275539 no 1952 0.428718628200047 2889 704384 SGTC_881 0833-0569 170 µM -0.18126139786176 0.43264013980106 no 1953 0.428081202063629 2746 5418700 SGTC_1885 st057546 99.9 µM -0.181601142728603 0.432517874864401 no 1954 0.427947875997422 2880 702008 SGTC_1176 0848-0131 83.3 µM -0.181963120047964 0.432387616182266 no 1955 0.427805834301744 2828 6769040 SGTC_1315 1237-0019 3.69 µM -0.18212373691655 0.432329820047467 no 1956 0.427742810441318 2827 825140 SGTC_3007 9078383 71.4286 µM -0.182360221896721 0.432244726280235 no 1957 0.427650020328414 2765 6496995 SGTC_288 1315-0019 35.1 µM -0.182833837963774 0.432074315712975 no 1958 0.427464198625321 2780 6811474 SGTC_2238 6671620 73.2395 µM -0.183771001790206 0.431737154502411 no 1959 0.427096552944221 2678 729941 SGTC_1224 0823-0416 294 µM -0.184289996985746 0.431550458206123 no 1960 0.426892980390725 2858 3598164 SGTC_1309 pyrazolanthrone 13.4 µM -0.185027856853914 0.431285056829665 no 1961 0.426603593095951 2812 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2629 bisabolol 100 µM -0.186511187169378 0.430751610606398 no 1962 0.426021953344338 2893 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1240 0356-0016 42.1 µM -0.188355985192213 0.430088347045578 no 1963 0.425298800405738 2810 4305613 SGTC_59 0330-0160 1.33 µM -0.189350765176818 0.429730773733988 no 1964 0.424908955017509 2751 4293482 SGTC_43 0570-0105 72.5 µM -0.190714588167978 0.429240641773853 no 1965 0.424374604383701 2744 1114046 YDL195W SEC31 SGTC_2928 9011484 9.79 µM -0.191041127034367 0.429123306091218 no 1966 0.424246685893553 2860 2994751 SGTC_304 1310-0298 97 µM -0.191621846716786 0.428914650727332 no 1967 0.424019214212803 2745 1550234 SGTC_2661 dactinomycin 12.96 µM -0.192314632147444 0.428665755591696 no 1968 0.423747878764391 2745 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3213 9129884 49.47 µM -0.192688849438155 0.428531323358072 no 1969 0.423601328331507 2846 17190742 SGTC_1919 st067113 52.3 µM -0.193217427443519 0.428341453367159 no 1970 0.423394345388104 2880 1268243 SGTC_1066 ketoconazole 628 nM -0.194668245451649 0.427820391813666 no 1971 0.422826336372936 2898 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_674 0498-0004 451 µM -0.195222670618917 0.427621303100196 no 1972 0.422609315957163 2799 4231473 SGTC_1225 1216-0074 20.6 µM -0.196000808446414 0.427341912427677 no 1973 0.422304766610854 2775 4241466 SGTC_1397 3532-0190 20.1 µM -0.196290449558914 0.427237925978038 no 1974 0.422191418067836 2723 5322280 SGTC_543 3844-1095 191 µM -0.197287210532589 0.426880109260626 no 1975 0.421801393589997 2856 4230703 SGTC_457 grayanotoxin iii 135 µM -0.197394129681324 0.4268417310497 no 1976 0.421759561542771 2792 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_211 3455-0679 143.504 µM -0.197517214773403 0.426797550994085 no 1977 0.421711405673968 2808 748649 SGTC_3164 9100705 49.47 µM -0.197796037563047 0.426697473982343 no 1978 0.421602323246669 2908 17174235 SGTC_758 0868-0029 16 µM -0.198240997144436 0.426537775776226 no 1979 0.421428256427804 2882 762687 SGTC_302 1094-0063 18.9 µM -0.198433824581989 0.426468572788965 no 1980 0.421352827694249 2746 5440289 SGTC_2287 7945887 168.79 µM -0.200565003652752 0.425703874583111 no 1981 0.420519362504925 2856 1245853 SGTC_1390 3413-2614 145 µM -0.200670066926487 0.425666183546317 no 1982 0.420478283361055 2821 3421432 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.200871583568334 0.425593892143577 no 1983 0.420399493921599 2857 16725076 SGTC_2829 7992743 58.44 µM -0.200983520467908 0.425553737356826 no 1984 0.42035572995311 2961 16462845 SGTC_734 2023-0417 80 µM -0.201330382600274 0.425429313454166 no 1985 0.420220123523507 2887 3935732 SGTC_1896 st058441 89 µM -0.201392699007049 0.425406960545111 no 1986 0.420195761805311 2793 688759 SGTC_2995 9067767 71.4286 µM -0.201419550839208 0.425397328860817 no 1987 0.42018526455541 2853 11673567 SGTC_2730 imipramine 71.33 µM -0.201746045871673 0.425280219481808 no 1988 0.42005763162865 2766 3696 A tricyclic antidepressant. SGTC_2311 7694451 200 µM -0.202247176458991 0.425100483505125 no 1989 0.419861746803103 2841 2163142 SGTC_1872 amphotericin b 148 nM -0.20445502918467 0.424308798800891 no 1990 0.418998965588724 2893 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2026 5148700 152 µM -0.205523839791135 0.423925657615953 no 1991 0.418581437085348 2758 79838 SGTC_3268 9137683 49.47 µM -0.205738311671018 0.423848783598357 no 1992 0.418497665151848 2749 1953228 SGTC_3337 9144342 33.5465 µM -0.206360902205803 0.423625642397629 no 1993 0.418254504513951 2863 17682949 SGTC_822 1487-0950 154 µM -0.207434035007983 0.423241080932452 no 1994 0.417835452252243 2845 1958375 SGTC_2334 9017922 200 µM -0.208746107172873 0.422770993965513 no 1995 0.417323222309549 2931 3163164 SGTC_782 0083-0095 30.5 µM -0.208845404484297 0.422735422362119 no 1996 0.417284462567653 2737 3591729 An indicator and reagent. SGTC_2720 fluspirilene 36.88 µM -0.208902560181051 0.422714947574017 no 1997 0.417262152760545 2867 3396 An atypical antipsychotic. SGTC_862 0452-0056 10.2 µM -0.209818524546601 0.422386851737122 no 1998 0.41690465718831 2768 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_854 0422-0053 192 µM -0.209856898990861 0.422373107293675 no 1999 0.416889681362954 2787 3596728 SGTC_3100 9120536 49.47 µM -0.213388556854886 0.421108592239014 no 2000 0.415511952638461 2728 16421196 SGTC_2663 amphotericin b 100 µM -0.214334893224144 0.420769892809155 no 2001 0.415142954688501 2794 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1409 3909-8004 61.9 µM -0.21441878559012 0.420739870057111 no 2002 0.415110246764536 2821 2119279 SGTC_2232 chlorophetanol 41.5365 µM -0.214430237422143 0.420735771799665 no 2003 0.415105781974225 2802 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_701 4424-0219 185 µM -0.214972975276742 0.420541552521431 no 2004 0.414894194289789 2930 2911779 SGTC_1422 4031-0024 15.5 µM -0.215519455541407 0.420346013560331 no 2005 0.414681172558991 2813 782427 SGTC_2751 anetholtrithion 17.25 µM -0.215609172886029 0.420313913205271 no 2006 0.414646202522567 2931 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1450 4112-4260 37.6 µM -0.215865597017716 0.42022216903389 no 2007 0.414546257226946 2910 1633175 SGTC_3217 9129673 49.47 µM -0.216133852133775 0.420126196577554 no 2008 0.414441706542051 2966 17248312 SGTC_1546 5-methoxyflavanone 78.7 µM -0.216280743560884 0.42007364588783 no 2009 0.414384459132643 2871 147795 SGTC_807 1315-0151 48 µM -0.21684955049317 0.419870167567133 no 2010 0.414162797445333 3011 4011080 SGTC_1721 st082152 9.2685 µM -0.216904188289841 0.419850623209264 no 2011 0.414141506762136 2756 5296051 SGTC_833 3852-0053 558 µM -0.217514829504355 0.419632205636255 no 2012 0.413903575684249 2948 3123681 SGTC_2015 5119600 184 µM -0.217705854792088 0.419563883720958 no 2013 0.41382915081496 2971 2828786 SGTC_3041 9091929 49.47 µM -0.217965019516362 0.419471194998947 no 2014 0.413728183264173 2952 25236887 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.219023588500166 0.419092650548135 no 2015 0.413315836439937 2758 1241132 A phosphatase inhibitor. SGTC_922 1866-0035 480 µM -0.219352143338331 0.418975174493324 no 2016 0.413187873132615 2794 3156169 SGTC_1251 0490-5699 265 µM -0.2203543837555 0.418616864221825 no 2017 0.412797584367554 2929 3883818 SGTC_2348 9022543 33.42 µM -0.22051190225442 0.418560556024772 no 2018 0.41273625192254 2928 3162678 YDL140C RPO21 SGTC_3150 9097574 49.47 µM -0.220882548853968 0.418428067430198 no 2019 0.412591942916546 2926 17217476 SGTC_190 3970-0790 3.722 µM -0.221354514464367 0.418259375486411 no 2020 0.412408203070114 2818 2832352 SGTC_2925 9010536 32.5 µM -0.221606083399953 0.418169464794592 no 2021 0.412310273186172 2873 2994177 SGTC_2618 avocadyne 43.43 µM -0.221869556165905 0.418075304260397 no 2022 0.412207715273438 2802 3015189 SGTC_269 exalamide 29 µM -0.222014733449029 0.418023422458051 no 2023 0.412151206949933 2824 3316 A derivative of salicylamide. SGTC_3033 9090887 49.47 µM -0.223884675325626 0.417355291779492 no 2024 0.411423520197607 2806 19325384 SGTC_1139 k015-0024 46.9 µM -0.224014179489574 0.417309028721492 no 2025 0.411373134980143 2862 2766652 SGTC_1434 4073-0095 163 µM -0.225041651705772 0.416942023177326 no 2026 0.410973435910374 2823 24133745 SGTC_387 norethindrone acetate 66.7 µM -0.225141944013962 0.416906203371692 no 2027 0.410934425938144 2851 541197 SGTC_1033 k072-0102 21.3 µM -0.225424466223494 0.416805303125334 no 2028 0.410824540058696 2982 5965931 SGTC_1115 galangin 695.678 nM -0.228101455261835 0.415849513637183 no 2029 0.409783684390091 2841 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1692 fluoroquinolonic acid 71 µM -0.229290024257514 0.415425307310179 no 2030 0.409321753228926 2924 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1495 4469-0029 237 µM -0.230873456373693 0.414860325511932 no 2031 0.408706556217786 2799 793680 SGTC_179 1273-0063 6.77 µM -0.232262650911976 0.4143647942425 no 2032 0.408167009757514 2823 3108139 SGTC_2099 5377090 177.372 µM -0.233213824557611 0.414025585330534 no 2033 0.407797685676825 2901 2243829 SGTC_2113 5491891 107.031 µM -0.235002252951751 0.413387967265636 no 2034 0.407103492291429 2838 789979 SGTC_647 0140-0236 81 µM -0.235939622870839 0.413053863272613 no 2035 0.406739760723021 2856 990837 SGTC_476 mead acid 10 µM -0.236449568780064 0.41287213118566 no 2036 0.406541918042359 2823 5312531 An omega 9 fatty acid. SGTC_1487 3970-0795 2.82 µM -0.236936859414351 0.412698490322451 no 2037 0.406352887169777 2905 3765103 SGTC_27 0485-0001 32.618 µM -0.237176742872844 0.412613016661782 no 2038 0.406259839055532 2789 2054479 SGTC_1011 4112-3381 17.4 µM -0.237994958345926 0.412321506821057 no 2039 0.405942502265599 2991 2877139 SGTC_1119 parthenolide 318.541 nM -0.238821570542138 0.412027054546794 no 2040 0.405621971633967 3033 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2994 9053520 71.4286 µM -0.23897522529117 0.411972325760158 no 2041 0.405562396787859 2973 4647384 SGTC_1756 st041558 35.5 µM -0.239413223145567 0.411816328975385 no 2042 0.405392588763149 3017 3955792 SGTC_779 1360-0071 233 µM -0.240138801517296 0.411557938538196 no 2043 0.405111327424191 3028 7566 SGTC_2179 6298986 200 µM -0.240868842439472 0.411297997619422 no 2044 0.404828385689481 2974 738374 SGTC_871 0574-0004 149 µM -0.241639626931044 0.411023591660384 no 2045 0.404529706976532 2831 9551173 SGTC_1496 4469-0713 57.4 µM -0.244228121003073 0.410102384652113 no 2046 0.40352707447981 2955 746691 SGTC_905 2-aminofluorene 215 µM -0.244539430855293 0.409991627356176 no 2047 0.403406533657055 2836 1539 An established DNA mutagen. YPR165W RHO1 SGTC_306 1672-3436 11.6 µM -0.244573447239315 0.409979525499267 no 2048 0.403393362889002 2925 6797378 SGTC_2455 5377712 9.75 µM -0.245631372833213 0.409603194895909 no 2049 0.402983800555581 2925 2243908 SGTC_986 1493-0483 84 µM -0.245799724901553 0.409543315524241 no 2050 0.40291863501362 2920 40079 SGTC_2073 5212005 126 µM -0.248113118873766 0.408720703113457 no 2051 0.402023442765561 2793 691789 SGTC_618 k072-0232 33.2 µM -0.248461263924302 0.408596942030109 no 2052 0.401888768717225 2941 5872756 YGL099W LSG1 SGTC_725 1497-0963 19 µM -0.249917900223715 0.408079225561577 no 2053 0.401325420008715 2979 3549977 SGTC_1562 morin hydrate 59.1 µM -0.251031358373257 0.407683589326588 no 2054 0.400894932395771 3033 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_411 enrofloxacin 100 µM -0.251411070087902 0.40754869088444 no 2055 0.400748154910981 3009 71188 A bacterial gyrase inhibitor. SGTC_769 0302-0231 76 µM -0.251554420894787 0.407497766149261 no 2056 0.40069274632843 2940 571869 YER009W NTF2 SGTC_2002 4023503 131 µM -0.252854413167002 0.407036021157174 no 2057 0.400190358963279 2934 4736863 YCR052W RSC6 SGTC_621 3584-0052 32.1 µM -0.255325499423557 0.40615867127751 no 2058 0.399235853383626 2942 2273927 SGTC_2624 nerol 100 µM -0.25552683001949 0.406087210298935 no 2059 0.399158111938441 2830 637566 A natural product oil. SGTC_1794 st048918 76.9 µM -0.258065707724804 0.405186321510837 no 2060 0.3981780983198 2909 672303 SGTC_702 1488-0190 94 µM -0.259888145550681 0.404539961699739 no 2061 0.397475027826336 2954 949357 SGTC_2671 danthron 100 µM -0.259894901725512 0.404537565986274 no 2062 0.397472422008587 2923 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.261350914826866 0.404021353013841 no 2063 0.396910953065964 2865 1377 SGTC_3317 9138495 8.753 µM -0.263127912697436 0.403391565009712 no 2064 0.396225995273836 2871 17020139 SGTC_1833 st055984 71 µM -0.263229653042886 0.403355514653662 no 2065 0.396186788330175 2904 676288 SGTC_917 harmaline 728.087 nM -0.264643012945838 0.402854794202379 no 2066 0.395642240786884 2986 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2877 9040724 71.43 µM -0.26572354587604 0.402472093975436 no 2067 0.395226064062605 3078 6463895 SGTC_1209 2323-2347 50.3 µM -0.266464032595929 0.402209884334752 no 2068 0.394940928081604 2913 5412760 SGTC_136 0097-0015 404.482 µM -0.268072911403524 0.401640324996898 no 2069 0.3943215982534 2884 4861337 SGTC_2936 9038235 15.59 µM -0.268169556099428 0.401606118437479 no 2070 0.394284403850393 2851 4749415 SGTC_503 tyrphostin 8 294 µM -0.26929874722829 0.401206506873328 no 2071 0.393849898075465 3002 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.271750297019053 0.400339279518067 no 2072 0.392907012299094 3299 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1188 1403-0014 4.57 µM -0.272454233366783 0.400090355012993 no 2073 0.392636388526518 2902 9614867 SGTC_2051 5263410 176 µM -0.272719252920552 0.399996649861565 no 2074 0.392534516915096 2919 227584 SGTC_3167 9103034 49.47 µM -0.273802409405578 0.399613729193118 no 2075 0.392118235958231 2868 5127859 SGTC_3119 9125183 49.47 µM -0.274593083384709 0.399334268732963 no 2076 0.391814440402682 2941 22695334 SGTC_283 0987-0079 11.7 µM -0.275612938941671 0.39897388117341 no 2077 0.391422685310856 2977 411556 SGTC_2295 7971645 200 µM -0.275818999965167 0.398901075593029 no 2078 0.391343544856846 2953 2978226 YKL099C UTP11 SGTC_575 k072-0246 11.9 µM -0.275881916751706 0.398878846504435 no 2079 0.391319381731292 2880 6796779 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.275923337860738 0.398864212218601 no 2080 0.391303474226971 3103 6728940 SGTC_1424 4048-1941 275 µM -0.276603373278009 0.398623972632745 no 2081 0.391042337113273 3024 X1424 SGTC_1751 st044839 27.194 µM -0.276989776001856 0.398487483275185 no 2082 0.390893978346411 2881 5291326 SGTC_1356 1502-0781 85.8 µM -0.277415184615168 0.398337230195114 no 2083 0.390730661688564 2898 567702 SGTC_2196 6573537 42.6665 µM -0.278928809251761 0.397802744749625 no 2084 0.390149729506529 3003 2903087 SGTC_2787 5284540 71.43 µM -0.279337851393769 0.397658338196576 no 2085 0.389992780345195 2963 736958 SGTC_466 geldanamycin 89.2 µM -0.281337294225247 0.396952665282707 no 2086 0.389225854149248 2962 5288382 HSP90 inhibitor. SGTC_348 k064-0012 10.7 µM -0.282759007780108 0.396451098153412 no 2087 0.388680789744576 2855 5066323 SGTC_312 4092-0653 6.84 µM -0.283773037497149 0.396093462653753 no 2088 0.388292159214525 3010 1148278 SGTC_1165 k072-0275 30.3 µM -0.283916499275312 0.396042872546119 no 2089 0.388237185993005 3004 6153523 YGL055W OLE1 SGTC_2427 5545055 42.75 µM -0.284464723488071 0.395849563865804 no 2090 0.388027132200201 2933 5372858 SGTC_1884 5633444 25 µM -0.284849250395614 0.39571399157555 no 2091 0.3878798190745 3069 5724239 SGTC_2525 harmine 47.85 µM -0.285345279916253 0.395539125550401 no 2092 0.387689812879964 2946 5280953 A monoamine oxidase inhibitor SGTC_200 k038-0079 37.545 µM -0.28580921281276 0.395375593625823 no 2093 0.387512125769189 2917 3436683 SGTC_802 4112-3352 742 µM -0.28585383244953 0.395359866599736 no 2094 0.38749503761159 3054 704594 SGTC_1178 0988-0033 191 µM -0.286897237570814 0.394992147577587 no 2095 0.387095502859466 3048 5392207 SGTC_470 aa-861 153 µM -0.287208871194242 0.394882339122129 no 2096 0.386976197058974 2939 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_777 1315-0167 517 µM -0.287637413665711 0.394731349839708 no 2097 0.38681215132115 3006 4221767 SGTC_1758 st042942 75.2445 µM -0.288627221150408 0.394382669325727 no 2098 0.386433331086553 2912 669317 SGTC_718 1130-0073 349 µM -0.291158311868663 0.393491424802498 no 2099 0.385465122140824 3088 6740020 SGTC_1485 3909-9022 254 µM -0.292270896799735 0.393099838968994 no 2100 0.385039754399676 2952 714516 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.292876398651143 0.392886771712701 no 2101 0.384808314690567 2934 115019 SGTC_3054 9094397 49.47 µM -0.294089078891088 0.392460143800891 no 2102 0.384344917932925 2969 2598354 SGTC_166 k072-0058 166.424 µM -0.295479553524003 0.391971125823194 no 2103 0.383813784685218 3024 5846229 SGTC_2198 6589944 200 µM -0.295610539790988 0.391925067859479 no 2104 0.383763761804537 2954 5290268 SGTC_2152 5568786 200 µM -0.297304595063114 0.391329533410563 no 2105 0.383116986907498 2933 5399883 SGTC_2893 9048488 25.97 µM -0.298410617268743 0.390940855591261 no 2106 0.382694893302228 2967 6467338 SGTC_2340 7987427 183.45 µM -0.298514329228431 0.390904414761017 no 2107 0.382655320622248 3055 2239331 SGTC_1913 st060213 96.1 µM -0.299709623184447 0.39048449862368 no 2108 0.382199328812694 3114 688959 SGTC_2453 5731132 22.18 µM -0.30019672244419 0.390313413433222 no 2109 0.382013552482186 3084 1362040 SGTC_3162 9099653 49.47 µM -0.300956738011769 0.390046513544004 no 2110 0.38172374200678 3056 25237511 SGTC_2160 5660466 132.927 µM -0.303887066388026 0.389017936173163 no 2111 0.380606965821393 2998 2859134 SGTC_1743 st037606 46.3785 µM -0.305567282921317 0.388428511918387 no 2112 0.379967067054216 2958 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1494 4358-1428 177 µM -0.306417103514079 0.388130490397341 no 2113 0.379643543769694 3088 1564571 SGTC_1583 clindamycin 39.6 µM -0.306427813184427 0.388126735068937 no 2114 0.379639467178248 2934 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_955 1216-0110 33 µM -0.307443525239124 0.387770624885246 no 2115 0.379252901473634 2890 3619719 SGTC_3324 9138759 60.749 µM -0.30745420622051 0.38776688061793 no 2116 0.379248837083173 3080 45595710 SGTC_2743 auranofin 4.32 µM -0.307756307077042 0.387660982091754 no 2117 0.379133885400427 2976 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1158 4092-0494 91.8 µM -0.309213844116607 0.387150174161454 no 2118 0.378579431760256 3093 1148199 SGTC_2359 9039622 200 µM -0.310218870525843 0.38679806669007 no 2119 0.378197260659622 2915 6463596 SGTC_453 enantio-paf c16 10 µM -0.31051469845558 0.386694442147169 no 2120 0.378084791880987 3059 13871343 A lipid and platelet activating factor SGTC_1731 st035964 63 µM -0.311292788107523 0.386421926395184 no 2121 0.377789024690387 2966 6739575 SGTC_3136 9095672 49.47 µM -0.312214658849427 0.386099125692007 no 2122 0.37743869619823 2867 17217380 SGTC_1504 k297-0033 30 µM -0.312229072396141 0.386094079294174 no 2123 0.377433219574911 2912 4388117 SGTC_1423 4048-0112 5.59 µM -0.315658343656485 0.384893989787727 no 2124 0.376130924074009 3046 X1423 SGTC_608 k048-0125 159 µM -0.315766632896281 0.384856111349488 no 2125 0.376089823171822 3082 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2260 7964312 200 µM -0.31694878664544 0.384442677942254 no 2126 0.375641231265848 3133 231951 SGTC_2135 5326629 150.42 µM -0.317198306274958 0.384355430480709 no 2127 0.375546567506771 3005 5020077 SGTC_3235 9132602 49.47 µM -0.317285438339973 0.384324965113296 no 2128 0.375513512758672 3082 4912240 SGTC_2803 7707263 71.43 µM -0.319184614995671 0.383661103653864 no 2129 0.374793261373057 2969 2199229 SGTC_1855 st056195 39.6 µM -0.31933685305222 0.383607903251664 no 2130 0.374735544866104 3139 4028379 SGTC_3094 9117742 49.47 µM -0.320647913100363 0.383149837221146 no 2131 0.374238611906968 2925 17149698 SGTC_630 4356-0227 183 µM -0.320998248921871 0.383027462416105 no 2132 0.374105858951665 2989 779312 SGTC_2651 TUB2.036 5 µM -0.32105741084964 0.383006797883918 no 2133 0.374083442161122 3115 15992207 YFL037W TUB2 SGTC_900 1112-0045 141 µM -0.321124527501588 0.382983355267741 no 2134 0.374058011795912 3007 56211 YIL048W NEO1 SGTC_1925 st057770 10.1 µM -0.321818925197559 0.382740840052627 no 2135 0.373794938086013 2978 5989122 SGTC_665 3914-0008 307 µM -0.322797665290386 0.382399097632873 no 2136 0.373424240633729 2968 1069549 SGTC_570 0987-0065 62.6 µM -0.324802182556362 0.381699475148128 no 2137 0.372665396296391 2913 3104428 SGTC_539 4859-0462 2.54 µM -0.325427100217136 0.3814814434305 no 2138 0.372428923875984 3135 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1863 st057641 20.1 µM -0.325877350123 0.381324376021315 no 2139 0.372258576532701 3017 3921635 SGTC_2626 ethyl orsellinate 100 µM -0.326517108725896 0.38110123307982 no 2140 0.372016573548488 2959 75653 A natural product. SGTC_2464 5717415 7.67 µM -0.327604691132759 0.380721983352145 no 2141 0.371605287257739 3000 5285744 SGTC_1276 0871-0068 94.2 µM -0.328766154439325 0.380317097219477 no 2142 0.371166223541926 3062 3414906 SGTC_888 0916-0002 6.97 µM -0.329290629643784 0.380134308090334 no 2143 0.370968013008231 3162 2802138 YIL048W NEO1 SGTC_118 0083-0097 135.343 µM -0.329345303402873 0.380115254832876 no 2144 0.370947352580324 3016 5207356 SGTC_209 4077-0173 175.592 µM -0.32958494346765 0.380031746103258 no 2145 0.370856800432989 3058 15993494 SGTC_1279 0874-0590 65.2 µM -0.330025982980514 0.379878069189692 no 2146 0.370690164713816 3029 3523074 SGTC_1138 3761-0006 1.03 µM -0.332083259931298 0.379161477401804 no 2147 0.369913195096249 2997 12061087 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.332121594137333 0.379148128742341 no 2148 0.369898722483879 3051 688801 SGTC_487 nimodipine 119 µM -0.332782427136921 0.378918037482493 no 2149 0.369649262020125 3049 4497 L-type voltage-gated calcium channels inhibitor SGTC_428 3448-4153 16.5 µM -0.333460615973907 0.37868194780917 no 2150 0.369393306867139 2925 3834874 SGTC_2798 7813637 45.45 µM -0.33359040090807 0.378636772508076 no 2151 0.369344331348107 3118 956368 SGTC_2570 licareol 100 µM -0.334326167201633 0.378380699695976 no 2152 0.369066723385658 3057 443158 SGTC_801 0866-0028 10.1 µM -0.33476013688701 0.378229687857054 no 2153 0.368903016657866 2955 6849771 SGTC_2259 7964009 200 µM -0.337115459704464 0.377410412642181 no 2154 0.36801493185771 3146 313134 SGTC_1219 1469-0211 33.1 µM -0.338479433077832 0.376936220155891 no 2155 0.3675009617241 3120 6822282 SGTC_3099 9120367 49.47 µM -0.340223462699178 0.376330169522795 no 2156 0.366844125150509 2987 24824940 SGTC_1622 st003707 19.4 µM -0.341636420507481 0.375839389811485 no 2157 0.366312262487744 3135 10140899 SGTC_642 0335-0876 158 µM -0.348844332275486 0.373338918832601 no 2158 0.363603089600334 3025 6812350 SGTC_342 k048-0088 23.3 µM -0.350008327201737 0.372935618096883 no 2159 0.363166224126866 2999 6820570 SGTC_410 α-linolenic acid 100 µM -0.351712591933538 0.372345376024624 no 2160 0.362526908108226 3143 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_260 nsc-65238 3.989 µM -0.351858482596948 0.372294863271136 no 2161 0.36247219833329 3152 3246252 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.351947204712116 0.372264145461662 no 2162 0.362438928441268 2989 5355888 SGTC_1016 4226-1401 38 µM -0.352381558108501 0.372113773213255 no 2163 0.362276065326013 3070 2901613 SGTC_1481 3346-2004 36 µM -0.353702489734617 0.371656589330385 no 2164 0.36178092826666 3104 2770522 SGTC_1667 st014849 34.6 µM -0.354418378976421 0.371408890513206 no 2165 0.361512681449213 3013 5348460 SGTC_2126 5251174 33.877 µM -0.354782086029855 0.371283067684223 no 2166 0.361376424893885 3209 790722 SGTC_29 0299-0004 12.984 µM -0.355210445635152 0.371134896235129 no 2167 0.361215969926231 3060 16871 A napthoquinone isolated from Swertia calycina. SGTC_297 0986-0032 24 µM -0.356210865839248 0.370788920968847 no 2168 0.360841327594086 2991 2847425 SGTC_433 pimozide 108 µM -0.356449808128689 0.370706303011054 no 2169 0.360751867033332 2981 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_677 0929-0063 136 µM -0.357229210166621 0.370436854269051 no 2170 0.360460110041885 3081 1539583 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.357716819717534 0.370268314038676 no 2171 0.360277622306944 3023 16623 A steroid. SGTC_2582 agaric acid 100 µM -0.357740331677211 0.370260187855896 no 2172 0.360268823766809 3136 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_218 alverine citrate 93.75 µM -0.359173811850696 0.369764859213633 no 2173 0.359732533203234 3171 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2289 7946404 165.07 µM -0.35975509494848 0.369564062579583 no 2174 0.359515143414071 3002 1246120 YPR165W RHO1 SGTC_149 3970-0822 46.1 µM -0.3606645863044 0.3692499620817 no 2175 0.359175100656977 3153 3114250 YBL034C STU1 SGTC_1197 1601-0112 267 µM -0.361856622317089 0.368838414580703 no 2176 0.358729588354126 3029 7350313 SGTC_1575 cyproterone acetate 48 µM -0.362521501662469 0.368608931909424 no 2177 0.358481179354158 3080 9880 An androgen receptor antagonist and liver toxin. SGTC_2989 9073649 71.4286 µM -0.362655082896132 0.36856283208322 no 2178 0.358431278600004 3116 21367202 SGTC_1376 2910-0861 41.3 µM -0.363114786054265 0.368404199740106 no 2179 0.358259569855755 3039 1112859 SGTC_1663 st014140 55.4 µM -0.363943227574882 0.368118381429576 no 2180 0.357950202005644 3084 4207120 SGTC_767 0929-0023 86 µM -0.363994200580848 0.368100797756152 no 2181 0.357931170019364 3117 1204563 SGTC_1334 1486-0610 236 µM -0.3640866559097 0.368068905025234 no 2182 0.357896650520587 3127 3742339 SGTC_643 k048-0106 28.4 µM -0.364519341817204 0.367919660869045 no 2183 0.357735116592684 3131 6763920 SGTC_2060 5238662 140 µM -0.365617023253314 0.367541132666798 no 2184 0.357325435316076 3128 790130 SGTC_2374 9071832 200 µM -0.367999087236924 0.366720136570907 no 2185 0.356436957394369 3074 17381698 SGTC_3302 9125395 16.351 µM -0.368158818176972 0.366665105871942 no 2186 0.356377407698825 3080 17599668 SGTC_90 0870-0863 4.608 µM -0.368771382645269 0.366454089829362 no 2187 0.356149068467606 3008 1738164 SGTC_3313 9133968 57.047 µM -0.369115572368028 0.366335541155218 no 2188 0.356020791101437 3046 1494643 SGTC_1608 st001473 40.5 µM -0.369361474005482 0.366250853487718 no 2189 0.355929155071952 3061 7292267 SGTC_2847 9005661 71.43 µM -0.369998441996257 0.36603151422944 no 2190 0.355691825631297 3131 2991449 SGTC_2576 guaiol 23.12 µM -0.372675994807059 0.365109981236939 no 2191 0.354694802400459 3140 227829 SGTC_2685 mycophenolic acid 18.85 µM -0.374981288021732 0.364317192150291 no 2192 0.353837191496124 3088 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1914 st062367 72.6 µM -0.375856198472069 0.364016462604398 no 2193 0.353511902709615 3051 978205 SGTC_2583 asiatic acid 100 µM -0.37680939061346 0.363688920898212 no 2194 0.353157630791367 3236 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_38 0929-0051 58.268 µM -0.377492411366376 0.363454278372899 no 2195 0.352903851414867 3186 1379719 SGTC_1477 0139-0234 16 µM -0.378002807618368 0.363278972088029 no 2196 0.352714254139748 3117 620880 SGTC_256 clotrimazole 625 nM -0.378199708401536 0.363211350041252 no 2197 0.352641121033954 3130 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_968 1309-0633 340 µM -0.378991673262504 0.36293940697591 no 2198 0.352347023600361 3177 3761976 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.38049533789788 0.362423272326201 no 2199 0.351788878302451 3152 66535 A nucleotide analog. SGTC_1553 gossypol 38.6 µM -0.381160220831844 0.362195130121623 no 2200 0.351542182122632 3059 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1568 digitonin 820 nM -0.384061517274457 0.361200177955229 no 2201 0.350466426504635 3245 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3346 9158254 43.5805 µM -0.384097923403313 0.361187699015224 no 2202 0.350452935272721 3159 17639500 SGTC_1860 st056228 74.6 µM -0.38420224530184 0.361151941384064 no 2203 0.35041427714204 3190 688679 SGTC_1772 st048439 82.2 µM -0.384710029159377 0.360977909466611 no 2204 0.350226131928586 3164 2927068 YDL195W SEC31 SGTC_2652 actinonin 100 µM -0.385426521357347 0.360732396242526 no 2205 0.349960718154898 3062 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1263 0774-1208 64.8 µM -0.386446789584611 0.360382890180935 no 2206 0.34958290162072 3259 906585 SGTC_2910 7948405 25.97 µM -0.386496412210118 0.360365894281467 no 2207 0.349564529612632 3241 2971328 SGTC_1676 st018489 23.4 µM -0.388844407818016 0.359562014616503 no 2208 0.348695624082295 3082 3696235 SGTC_2153 5569715 200 µM -0.389002977809265 0.359507747599685 no 2209 0.348636971785962 3138 2054701 SGTC_1974 st069448 26.9 µM -0.389164770056666 0.359452380758246 no 2210 0.348577131361664 3225 6323587 YNR016C ACC1 SGTC_2115 tiliquinol 12.7705 µM -0.393148549903947 0.3580900269013 no 2211 0.34710488375184 3149 71208 A bioactive hydroxyquinoline. SGTC_467 ro 31-8220 72.8 µM -0.394048905375437 0.357782377124184 no 2212 0.346772466450057 3118 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_305 1682-2595 20.8 µM -0.39572464098593 0.357210027459874 no 2213 0.346154087718172 3165 226033 SGTC_2675 theaflavin digallate 100 µM -0.395871924926879 0.357159737773774 no 2214 0.346099756682641 3170 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2664 lyso-paf C-16 73.48 µM -0.396636896785182 0.356898580220388 no 2215 0.345817619980231 3086 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_247 mechlorethamine 29.705 µM -0.397288460709233 0.356676192436029 no 2216 0.345577377853118 3087 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_292 k038-0015 474 µM -0.399761285369407 0.355832626962192 no 2217 0.344666174056626 3204 46368540 SGTC_2241 6772625 37.8075 µM -0.399771428858984 0.355829168119295 no 2218 0.344662438163269 3173 2285411 SGTC_1836 st055642 81 µM -0.401774758753867 0.355146282784391 no 2219 0.343924900015572 3125 8571 SGTC_1924 st058459 75.1 µM -0.406037834125509 0.353694656194991 no 2220 0.342357400784488 3200 688683 SGTC_1274 0865-0114 173 µM -0.407267307448668 0.353276400105158 no 2221 0.341905835741762 3161 870624 SGTC_1456 k015-0012 13 µM -0.408979582503524 0.352694194324712 no 2222 0.341277322435986 3308 2989616 SGTC_688 0527-0193 473 µM -0.409523381528281 0.352509364494953 no 2223 0.341077805762825 3120 4007154 SGTC_2747 doxorubicin 7.63 µM -0.410135797216447 0.352301254489112 no 2224 0.340853167230222 3123 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_207 4185-0010 4.486 µM -0.411107020653901 0.351971305757232 no 2225 0.340497031110741 3224 3761753 SGTC_1964 st076914 61 µM -0.413115208429967 0.351289428111864 no 2226 0.339761103666738 3167 24208661 SGTC_3025 9087895 49.47 µM -0.413180312205886 0.351267330200798 no 2227 0.339737255711484 3249 17173641 SGTC_2233 sulbentine 40.3845 µM -0.413531089732134 0.351148275859919 no 2228 0.339608774563029 3189 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_255 tunicamycin 200.472 nM -0.413959909173414 0.351002753837842 no 2229 0.33945173390521 3183 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_194 1486-1323 56.904 µM -0.41419149371021 0.350924173551832 no 2230 0.33936693546929 3172 5178754 SGTC_99 0109-0120 622.8 µM -0.416919390166452 0.349999035919154 no 2231 0.338368685105933 3344 759414 SGTC_1417 3966-0327 90.4 µM -0.418325649026719 0.34952246505356 no 2232 0.337854519563343 3192 651118 SGTC_186 3455-3465 67.277 µM -0.421324346725963 0.348507020852662 no 2233 0.336759127072791 3090 755278 SGTC_2838 9002687 71.43 µM -0.422420598563063 0.348136069191915 no 2234 0.336359022696605 3102 6457060 SGTC_1076 itraconazole 331 nM -0.422643673103327 0.348060602604167 no 2235 0.336277628763442 3213 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1366 1683-0113 21.9 µM -0.423364149310487 0.347816905095453 no 2236 0.336014798697351 3139 708623 SGTC_3283 9109332 35.8195 µM -0.423938523900558 0.347622670758831 no 2237 0.335805323989165 3152 17027281 SGTC_2607 solasodine 47.35 µM -0.426277000558598 0.34683228926818 no 2238 0.334953007460045 3152 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_478 N-arachidonylglycine 10 µM -0.426872538517364 0.346631109730248 no 2239 0.334736084218114 3200 5283389 SGTC_2257 7960413 200 µM -0.427452230371846 0.346435324719972 no 2240 0.334524985838061 3130 2974689 YIL048W NEO1 SGTC_1003 4049-0218 100 µM -0.428294148888452 0.346151048390998 no 2241 0.334218489151301 3303 295161 SGTC_518 1021-0119 62.6 µM -0.429976892709079 0.345583124717355 no 2242 0.333606225073187 3163 1097762 SGTC_358 0075-0058 9.45 µM -0.430640531887639 0.345359242870441 no 2243 0.333364882532768 3385 1069125 SGTC_2379 9035213 200 µM -0.431793556300268 0.344970393256087 no 2244 0.33294573161305 3289 646551 SGTC_1155 4088-0394 48.2 µM -0.432573591547404 0.344707424477877 no 2245 0.332662289126665 3143 2326248 SGTC_2021 4019055 173 µM -0.432640883323391 0.344684742303158 no 2246 0.332637841699411 3311 44827708 YER133W GLC7 SGTC_795 0685-0265 78 µM -0.432809315257651 0.344627971059079 no 2247 0.332576652684576 3245 302754 SGTC_2603 homopterocarpin 100 µM -0.433739745571514 0.344314425641142 no 2248 0.332238720509343 3248 101795 A weak amylase inhibitor. SGTC_102 gallobenzophenone 83.616 µM -0.434222526566355 0.344151775564919 no 2249 0.332063428226274 3334 70837 SGTC_2390 9097792 176.6 µM -0.434761125537233 0.343970354297471 no 2250 0.331867912434368 3197 4497149 SGTC_842 0271-0008 11.1 µM -0.436578099669779 0.343358591267415 no 2251 0.33120867406582 3298 1221709 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.438137914245362 0.342833739260506 no 2252 0.330643155795632 3145 15053 SGTC_2523 spermine 47.74 µM -0.442252100329745 0.341450839818866 no 2253 0.329153394209039 3258 1103 A DNA binding polyamine. SGTC_587 k089-0003 57 µM -0.442301618657171 0.341434208158506 no 2254 0.329135479897718 3259 9659696 SGTC_1638 st008370 60.6 µM -0.442893479056486 0.341235444569756 no 2255 0.32892139215257 3241 24207134 SGTC_3177 9107506 49.47 µM -0.443275805620606 0.341107071823113 no 2256 0.32878312681362 3249 8897194 SGTC_468 gf-109203x 121 µM -0.44384216907526 0.340916939314074 no 2257 0.328578349075519 3210 2396 A protein kinase C inhibitor. SGTC_3338 9144300 39.5675 µM -0.44400898876997 0.340860944376645 no 2258 0.328518042565235 3219 4901274 SGTC_3178 9107506 49.47 µM -0.444392033323986 0.340732384362187 no 2259 0.328379586130386 3307 8897194 SGTC_1588 farnesol 29.9 µM -0.444398072112772 0.340730357730955 no 2260 0.328377403520306 3181 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1196 1588-0294 184 µM -0.444522943868224 0.340688451516699 no 2261 0.328332272214445 3213 6144269 SGTC_2763 lisinopril 49.32 µM -0.444996163676822 0.340529659627823 no 2262 0.328161263259857 3280 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1032 k061-1018 98.7 µM -0.446259969152746 0.340105720333999 no 2263 0.327704734410943 3366 4005393 SGTC_885 0865-0106 16.8 µM -0.447540365182483 0.339676421844443 no 2264 0.32724247499507 3172 2793380 SGTC_1118 chelidonine 707.474 nM -0.44834402109746 0.33940707365838 no 2265 0.326952467562497 3292 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.448842024482346 0.339240207174338 no 2266 0.326772810381942 3327 688798 SGTC_2522 biochanin a 4.94 µM -0.450538088525725 0.338672141994897 no 2267 0.326161248360679 3317 5280373 A possible chelator. SGTC_183 3914-0051 30.55 µM -0.451442738847278 0.338369296068919 no 2268 0.325835243025432 3313 1596232 SGTC_2691 st077356 60.2 µM -0.454018168195437 0.337507703461465 no 2269 0.324907875131751 3340 2839272 SGTC_1090 efavirenz 20.7 µM -0.454382407648181 0.337385918195295 no 2270 0.324776806118892 3237 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1377 2944-0135 198 µM -0.458036225071046 0.336165190528904 no 2271 0.323463207975332 3265 1894137 SGTC_2585 alliin 100 µM -0.458055940763004 0.336158608254607 no 2272 0.323456125855852 3394 87310 A garlic compound which reacts with lipids. SGTC_2804 7954240 19.48 µM -0.461415302507287 0.335037787815 no 2273 0.322250337399091 3311 828705 SGTC_2702 st077768 96.8 µM -0.46144556624216 0.335027697250555 no 2274 0.322239483194003 3262 6484119 SGTC_1648 st011736 69.8 µM -0.461920380274805 0.334869399879006 no 2275 0.322069209161923 3353 2855514 SGTC_1351 1496-0003 46.5 µM -0.463905715124858 0.334207830810086 no 2276 0.321357649005997 3340 3891978 SGTC_3196 9111891 49.47 µM -0.465014222276861 0.333838669024985 no 2277 0.32096063586679 3276 18891510 SGTC_2151 5563267 85.4165 µM -0.466883980186147 0.333216355301509 no 2278 0.320291443668034 3247 5310824 SGTC_1430 4049-0248 69.1 µM -0.46796559960637 0.332856568031513 no 2279 0.319904595176431 3316 22774488 SGTC_984 1492-0255 2.91 µM -0.471175866208096 0.331789619673769 no 2280 0.318757575740911 3308 1585198 SGTC_163 TUB2.036 7.546 µM -0.471203470283404 0.331780451217623 no 2281 0.318747720385215 3319 15992207 YJR013W GPI14 SGTC_1850 st056238 17 µM -0.472227811860834 0.33144029625457 no 2282 0.318382095124346 3315 5393177 SGTC_2458 5808907 16.39 µM -0.472635479972965 0.331304959815394 no 2283 0.318236632522135 3368 2731747 SGTC_972 1319-0219 195 µM -0.472721002343569 0.331276571149719 no 2284 0.318206120307205 3284 23903702 SGTC_3330 9141424 71.43 µM -0.47276783644423 0.331261025246605 no 2285 0.318189411609443 3334 27261020 SGTC_1336 1486-0901 104 µM -0.474714877442146 0.330614990734889 no 2286 0.317495106175825 3292 5006114 SGTC_2946 9065502 71.43 µM -0.474750584195975 0.330603147821764 no 2287 0.317482379302882 3233 16489101 SGTC_2811 7967822 32.47 µM -0.47497205712426 0.330529695348967 no 2288 0.317403445055809 3344 2232244 SGTC_724 3910-0327 137 µM -0.475774898406663 0.330263484233893 no 2289 0.317117377350987 3302 2885483 SGTC_3155 9099265 49.47 µM -0.477073820947011 0.329832961346207 no 2290 0.316654777831127 3316 25236499 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.477455793388544 0.329706400896522 no 2291 0.316518796299801 3394 23847180 SGTC_646 4092-0839 27.3 µM -0.477632188606931 0.329647961746604 no 2292 0.316456008274795 3387 877796 SGTC_1812 st052057 4.327 µM -0.479849482276413 0.328913734845023 no 2293 0.31566721239607 3235 3645418 SGTC_1708 st033234 31.827 µM -0.480108170729746 0.328828116571371 no 2294 0.315575239301636 3378 674664 SGTC_2134 5324836 1.464 µM -0.480245016584408 0.328782828248448 no 2295 0.315526590273608 3212 699272 SGTC_1770 st043884 66.3 µM -0.480307432630272 0.328762172863551 no 2296 0.315504402281904 3286 670149 SGTC_2836 9010338 19.48 µM -0.480895691947333 0.328567525507511 no 2297 0.315295317381615 3228 2994051 SGTC_70 0141-0289 43.283 µM -0.481430400605089 0.328390637716618 no 2298 0.315105317290309 3266 352408 SGTC_2381 9035592 200 µM -0.483829362661423 0.327597507228568 no 2299 0.314253487331713 3292 4749657 SGTC_973 1325-0077 65.9 µM -0.483901752969628 0.327573586042537 no 2300 0.314227798124434 3275 2835149 SGTC_853 0419-0306 21 µM -0.48574754554874 0.326963888095158 no 2301 0.313573084494158 3243 762713 SGTC_1845 st056753 3.01 µM -0.4858709731129 0.326923134235047 no 2302 0.31352932491211 3200 5375839 SGTC_1510 1123-0200 71.5 µM -0.487052555369866 0.326533098697441 no 2303 0.313110543701421 3445 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1332 1480-0653 17.5 µM -0.489407529628431 0.32575629688942 no 2304 0.312276603182611 3351 5749438 SGTC_2351 9026858 72.31 µM -0.491055609597067 0.325213117597103 no 2305 0.311693558329239 3212 1409300 SGTC_2385 9074692 200 µM -0.491802283908767 0.324967148472906 no 2306 0.311429560906873 3287 17046906 SGTC_2028 5153890 36.43 µM -0.49187636575602 0.324942748620841 no 2307 0.311403373489779 3298 2830968 YPR165W RHO1 SGTC_729 4092-0585 94.1 µM -0.493771239309878 0.324318902028789 no 2308 0.310733873538441 3239 2169061 SGTC_3000 9075062 71.4286 µM -0.493921186157524 0.324269556255655 no 2309 0.310680920772504 3253 17057871 SGTC_1705 st027868 56.3335 µM -0.49442722751057 0.324103046687444 no 2310 0.310502244474674 3329 292948 SGTC_2617 dihydrotanshinone i 20.83 µM -0.495901049249032 0.323618295903441 no 2311 0.309982112922424 3260 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1902 st060212 70.5 µM -0.496376328096343 0.323462036949426 no 2312 0.309814461603625 3394 688944 SGTC_2529 gangaleoidin 93.61 µM -0.497749675276024 0.323010692193034 no 2313 0.309330245244548 3262 4565183 SGTC_1726 st035556 14.5795 µM -0.497970390817905 0.322938179241041 no 2314 0.309252455944466 3428 5919439 SGTC_2768 sulfasalazine 50.2 µM -0.498717788500168 0.322692682356592 no 2315 0.308989105548518 3436 5384001 An antioxidant and salicylic acid derivative. SGTC_1549 4'-methoxyflavonol 74.6 µM -0.500024178624679 0.32226375944867 no 2316 0.308529026322044 3346 97141 SGTC_1989 st071868 50.2 µM -0.500161449378777 0.322218703503652 no 2317 0.308480700292102 3377 16414057 SGTC_96 0929-0093 37.281 µM -0.500747269925076 0.322026450847897 no 2318 0.308274500063397 3280 6991579 SGTC_231 b-estradiol 524 µM -0.501376563384338 0.321819984444686 no 2319 0.308053065387492 3254 450 A steroid. SGTC_221 trifluoperazine 10.304 µM -0.501643440285401 0.321732440766317 no 2320 0.30795917830304 3362 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2214 7179297 48.276 µM -0.502320762452623 0.321510303091289 no 2321 0.307720953334793 3332 769744 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.503024543475175 0.321279555447334 no 2322 0.307473508216385 3309 2374 Ca(2+)-ATPase inhibitor. SGTC_321 4534-3890 65.3 µM -0.503369457787313 0.321166494079353 no 2323 0.307352270421023 3358 699746 SGTC_2331 7980721 200 µM -0.50354944487024 0.321107501699447 no 2324 0.3072890131016 3288 2981221 SGTC_2228 7354201 200 µM -0.508010408424274 0.319646826616878 no 2325 0.305723021916167 3319 753451 SGTC_715 0868-0130 184 µM -0.508184484735305 0.319589884442041 no 2326 0.305661985313346 3430 2876258 SGTC_1879 gemcitabine 100 µM -0.509387756934553 0.319196397932767 no 2327 0.305240228143661 3329 60750 A nucleoside analog which inhibits DNA replication. SGTC_1287 0971-0001 34.6 µM -0.509784167485092 0.31906681080994 no 2328 0.305101339435253 3379 4665869 SGTC_2082 5219693 150 µM -0.510524842432718 0.318824742465214 no 2329 0.304841907467312 3333 2834649 SGTC_1419 3993-2473 62.6 µM -0.514739410624884 0.317448805158011 no 2330 0.303367564841105 3364 704026 SGTC_1359 1582-0056 520 nM -0.516403199696174 0.316906317351481 no 2331 0.302786415741319 3400 3661189 SGTC_2248 tofa 1.1 µM -0.516510638198072 0.316871299931961 no 2332 0.302748905417371 3241 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2766 oltipraz 83.91 µM -0.516912183953035 0.316740438691756 no 2333 0.302608730982886 3407 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_3237 9133362 49.47 µM -0.518082413301835 0.316359199123156 no 2334 0.30220038503314 3377 43845137 SGTC_3032 9089427 49.47 µM -0.518587630524125 0.316194668753486 no 2335 0.3020241683589 3378 17173707 SGTC_1360 1598-0022 39.8 µM -0.518953368624626 0.316075584224771 no 2336 0.301896629951728 3389 761525 SGTC_109 0132-0036 33.701 µM -0.519340022174628 0.31594971036111 no 2337 0.301761824331725 3327 67274 A color developer. SGTC_212 3807-4682 38.772 µM -0.520866417485042 0.31545300558527 no 2338 0.301229915585642 3388 3125501 YBL034C STU1 SGTC_2843 9000894 45.46 µM -0.522293976206003 0.314988764821342 no 2339 0.300732831334903 3312 2242070 SGTC_12 0849-0099 9.267 µM -0.523492935268587 0.31459909011011 no 2340 0.300315633033487 3367 6071388 SGTC_1766 st045414 44.774 µM -0.525671938117387 0.313891419204691 no 2341 0.299558082232389 3411 253960 SGTC_592 k241-0073 46.5 µM -0.525823514367615 0.313842217470012 no 2342 0.299505417557217 3432 4230158 SGTC_2737 bleomycin 30.5 nM -0.529560669168309 0.312630183610449 no 2343 0.298208284941072 3415 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1183 1254-0324 198 µM -0.529823513512285 0.312545013961851 no 2344 0.298117150424615 3434 5799357 SGTC_2074 5212007 75.395 µM -0.530246534991093 0.312407963018397 no 2345 0.297970505255534 3394 758611 SGTC_2941 9056145 11.23 µM -0.531051216772487 0.31214733299746 no 2346 0.297691644038152 3393 2119517 SGTC_1187 1391-0724 117 µM -0.533665787251935 0.311301143807394 no 2347 0.296786391831951 3402 6997986 SGTC_902 1120-0002 2.07 µM -0.53444378187483 0.311049542869192 no 2348 0.296517267410748 3409 3280475 SGTC_3303 9125618 40.5795 µM -0.535378382436384 0.310747412808068 no 2349 0.296194117692756 3376 22695467 SGTC_1448 4255-0083 152 µM -0.535851701059924 0.310594450865955 no 2350 0.296030523568523 3465 5399660 SGTC_860 0443-0016 25.1 µM -0.536772639350573 0.310296925930345 no 2351 0.295712336619158 3409 5337942 SGTC_839 0122-0028 230 µM -0.537155365993837 0.310173316008238 no 2352 0.295580149656853 3336 759448 SGTC_1007 4101-0031 70 µM -0.537465205318155 0.310073262343756 no 2353 0.295473156578201 3439 1146276 SGTC_2886 9058944 51.95 µM -0.537802614604287 0.309964321749408 no 2354 0.295356663361542 3275 4949929 SGTC_1459 k035-0031 35.7 µM -0.537857132973068 0.309946720765704 no 2355 0.295337842448134 3341 3877128 YMR208W ERG12 SGTC_3141 9094609 49.47 µM -0.538006802117002 0.309898403067717 no 2356 0.295286176278092 3261 25236309 YDL196W YDL196W SGTC_3062 9077494 49.47 µM -0.541196328512129 0.308869509734043 no 2357 0.294186133924873 3411 16459633 SGTC_628 1636-0253 16 µM -0.541243903005077 0.308854174236961 no 2358 0.294169740200276 3394 4456143 SGTC_2782 7736369 71.43 µM -0.541959835568514 0.308623435745591 no 2359 0.293923087534222 3371 2950836 YOL077C BRX1 SGTC_2298 7976326 193.81 µM -0.541972462537801 0.308619366867021 no 2360 0.2939187381566 3358 2235818 SGTC_3183 9108214 49.47 µM -0.543036738375532 0.308276502155699 no 2361 0.293552253852104 3386 4974831 SGTC_577 r071-0003 38.6 µM -0.543126090433476 0.308247724301264 no 2362 0.293521495024521 3391 4568517 YMR134W ERG29 SGTC_1324 1418-0026 34.4 µM -0.544154014242199 0.307916742954411 no 2363 0.293167746771754 3419 1372513 SGTC_2715 st079500 56.4 µM -0.545351566080074 0.307531340049702 no 2364 0.292755872457492 3383 28246688 SGTC_3240 9133527 49.47 µM -0.545626998178241 0.307442728956981 no 2365 0.292661181044829 3390 17617455 SGTC_1249 0481-0015 10.2 µM -0.548541727462575 0.306505701469684 no 2366 0.291659992825096 3335 4227577 SGTC_1732 st034308 51.822 µM -0.550828292170314 0.305771500425508 no 2367 0.290875693803785 3355 830119 SGTC_2938 9059746 27.26 µM -0.553786256871727 0.304822874537499 no 2368 0.289862567417685 3412 6471769 SGTC_191 3914-0123 66.505 µM -0.55407248899728 0.304731148701526 no 2369 0.289764618538778 3329 3144412 SGTC_3186 9110464 49.47 µM -0.555659655193977 0.30422274888227 no 2370 0.28922177091898 3484 17018021 SGTC_1042 0350-0096 82 µM -0.555737342466963 0.30419787385823 no 2371 0.289195212348445 3363 3122515 SGTC_904 1141-0088 396 µM -0.556234540480041 0.304038695336181 no 2372 0.28902526483592 3413 1378119 SGTC_823 0417-1665 178 µM -0.557271578853267 0.303706805839598 no 2373 0.288670945472577 3427 3429856 SGTC_66 0109-0187 42.4 µM -0.557358388528024 0.303679030963703 no 2374 0.288641294956028 3482 759417 SGTC_1515 3460-0031 42.1 µM -0.559428109908202 0.303017156801778 no 2375 0.287934790780812 3409 2876596 SGTC_1898 st060199 18.6 µM -0.559791703782632 0.302900950162782 no 2376 0.287810761539572 3444 688866 SGTC_405 ebelactone b 50 µM -0.560352185249287 0.302721856236483 no 2377 0.287619619399044 3401 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_64 000l-0018 272.079 µM -0.563683334932048 0.301658414682991 no 2378 0.286484830474995 3440 6811119 SGTC_1363 1636-0063 10.4 µM -0.565465976353732 0.301090012362407 no 2379 0.285878430014458 3436 6072185 SGTC_1534 6-azauridine 81.6 µM -0.567582685723717 0.300415718703826 no 2380 0.28515918331827 3428 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_253 dyclonine 31.25 µM -0.568536494282981 0.300112098963523 no 2381 0.284835366308396 3505 3180 An oral anasthetic. SGTC_1978 st071761 42 µM -0.570008509480346 0.299643794424507 no 2382 0.284335963281645 3392 5147680 SGTC_491 tetrandrine 80.3 µM -0.57063698318365 0.299443953716375 no 2383 0.284122871787182 3466 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_650 1328-0195 38 µM -0.575492006734669 0.297902204653132 no 2384 0.282479297519037 3479 2780821 SGTC_313 3474-0040 5.03 µM -0.576918895774372 0.297449774466694 no 2385 0.281997122621684 3445 1043375 YIL048W NEO1 SGTC_500 h-89 112 µM -0.577324735981646 0.297321150209695 no 2386 0.281860053385603 3536 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_377 3970-0964 33.1 µM -0.578216569894531 0.297038587705393 no 2387 0.281558956557838 3483 16481235 SGTC_3352 9151559 45.5865 µM -0.578439047425339 0.296968118604415 no 2388 0.281483868911456 3419 17159339 SGTC_3296 9122258 64.045 µM -0.583700743334699 0.29530372621012 no 2389 0.279710833530909 3478 4730474 SGTC_1777 st045864 34.765 µM -0.583871188066989 0.295249882572899 no 2390 0.279653489455493 3508 4691462 SGTC_2483 5729050 27.16 µM -0.585658356853389 0.29468558672137 no 2391 0.279052561878716 3548 2865180 SGTC_364 0083-0097 67.7 µM -0.585830820389156 0.294631157946829 no 2392 0.278994605019237 3512 5207356 SGTC_1079 idarubicin 2.36 µM -0.586379932836234 0.294457891239057 no 2393 0.278810113232811 3486 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_62 0180-0423 3.232 µM -0.586574680582982 0.294396451918246 no 2394 0.278744695800972 3467 30102 YGL099W LSG1 SGTC_524 r073-0010 27.8 µM -0.587288771566205 0.29417122004333 no 2395 0.2785048904854 3437 2772106 SGTC_2958 9077254 16.72 µM -0.591279476074746 0.292913977790056 no 2396 0.277166589446329 3557 16457351 SGTC_2955 9076254 12.21 µM -0.59200856148025 0.292684554455833 no 2397 0.276922427673404 3442 16459619 SGTC_1967 st070177 51.4 µM -0.594120203282726 0.292020549638531 no 2398 0.276215859497992 3551 5729214 SGTC_2266 7929956 200 µM -0.59431061460406 0.291960709370673 no 2399 0.276152190225287 3526 2967153 SGTC_3325 9138760 55.175 µM -0.594773447483437 0.29181527941915 no 2400 0.275997459339851 3431 43844959 SGTC_2210 7115885 190.385 µM -0.595067658052747 0.291722851010333 no 2401 0.275899123164854 3513 2927039 SGTC_1234 0326-0494 15.5 µM -0.596185460148387 0.291371809730719 no 2402 0.275525668896643 3566 1547813 SGTC_204 PMA1.184 62.41 µM -0.598582640000687 0.290619650338089 no 2403 0.274725617697112 3527 2252213 YGL008C PMA1 SGTC_1052 3253-3998 198 µM -0.599004963425523 0.290487232743495 no 2404 0.27458478735991 3483 5450317 SGTC_2584 androsterone 48.74 µM -0.601368433966376 0.28974669901685 no 2405 0.273797309176119 3573 2754130 A steroid. SGTC_44 0929-0055 61.211 µM -0.602999140981142 0.289236275215736 no 2406 0.273254630335957 3432 1379590 SGTC_140 0062-0056 502.533 µM -0.60508227699485 0.28858485318087 no 2407 0.272562164779362 3491 3758964 SGTC_3175 9106517 49.47 µM -0.605232502522257 0.288537902558639 no 2408 0.272512261265717 3502 41468073 SGTC_2165 5727197 32.143 µM -0.606138436282656 0.288254843557957 no 2409 0.27221141475833 3678 1361712 SGTC_2405 ticlatone 3.52 µM -0.607540805853852 0.287816931655148 no 2410 0.271746035404404 3381 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_998 3996-0085 177 µM -0.608838006202937 0.28741214047782 no 2411 0.271315909533298 3505 715391 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.609561483356616 0.287186496572717 no 2412 0.271076166355798 3495 2724278 An inhibitor of dopamine biosynthesis. SGTC_397 arbidol 50 µM -0.609586902267382 0.28717857024238 no 2413 0.271067745053076 3566 131410 A RNA synthesis inhibitor. SGTC_533 1222-0222 6.71 µM -0.609993112092737 0.287051916662276 no 2414 0.2709331851638 3568 3982874 SGTC_1634 st006576 41 µM -0.610414563861058 0.286920538710526 no 2415 0.270793611510518 3556 3915356 SGTC_2491 paeonol 100 µM -0.610818913215753 0.286794518829171 no 2416 0.270659735469408 3504 11092 Increases levels of cortical cytochrome oxidase. SGTC_3249 9135183 49.47 µM -0.611617090020743 0.286545835369427 no 2417 0.270395564141908 3579 4902779 SGTC_89 0302-0250 142.109 µM -0.611703645239314 0.28651887399577 no 2418 0.270366924843662 3588 4203518 YLR208W SEC13 SGTC_3204 9114183 49.47 µM -0.612572678085576 0.286248242783424 no 2419 0.270079464244355 3538 17027248 SGTC_2673 kobusone 100 µM -0.613127882105384 0.286075406634664 no 2420 0.269895892719032 3582 6710676 An epoxy ketone and protein crosslinker. SGTC_1686 st019653 115.5 µM -0.613182361264434 0.28605844983266 no 2421 0.269877883206526 3558 97252 SGTC_3111 9122088 49.47 µM -0.61453473537796 0.2856376724797 no 2422 0.269431013445346 3460 16876704 SGTC_164 4100-3994 89.624 µM -0.61520360028606 0.285429670925709 no 2423 0.269210135223544 3596 4615967 SGTC_717 1532-0246 73.2 µM -0.617595400245231 0.284686467009009 no 2424 0.268421038716115 3511 9561992 SGTC_2563 tomatine 8.54 µM -0.617846240995534 0.284608576823525 no 2425 0.268338349414003 3584 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.620580456611157 0.283760218478628 no 2426 0.267437850851962 3604 804 An inhibitor of viral and cellular DNA polymerases. SGTC_220 paclitaxel 373.376 µM -0.622509687206484 0.283162356275717 no 2427 0.266803387973309 3534 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2333 9017922 200 µM -0.622743837290129 0.283089835084157 no 2428 0.266726435214184 3561 3163164 SGTC_3259 9138485 49.47 µM -0.62279494595856 0.283074006842889 no 2429 0.266709639987357 3692 17646153 SGTC_1668 st014914 51.6 µM -0.62465027007511 0.282499704840738 no 2430 0.26610030930119 3563 2839556 SGTC_167 3672-0051 66.205 µM -0.628877893327113 0.281193171756306 no 2431 0.264714499914361 3544 3237971 SGTC_3349 9149703 23.001 µM -0.632269210516394 0.280147210035968 no 2432 0.263605489528631 3572 4910494 SGTC_2451 5856223 45.7 µM -0.634236401003783 0.279541347594006 no 2433 0.262963277528475 3548 2179896 SGTC_2234 tolnaftate 200 µM -0.634584356144586 0.279434249362428 no 2434 0.262849766867105 3545 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1162 k048-0130 20.1 µM -0.635025684386699 0.27929844019851 no 2435 0.262705831887536 3565 6797406 SGTC_911 3456-4043 236 µM -0.637262742588492 0.278610527960397 no 2436 0.261976857504572 3606 914281 SGTC_2927 9011802 47.9 µM -0.637266984279618 0.278609224392582 no 2437 0.261975476280308 3555 43912568 SGTC_351 caspofungin 25 nM -0.637770889688493 0.278454383979839 no 2438 0.261811415850784 3606 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2090 5301565 104.445 µM -0.638173436189414 0.278330719338422 no 2439 0.261680393510802 3594 2056344 SGTC_1678 st019265 80.2 µM -0.638924792823381 0.278099969822289 no 2440 0.261435929186627 3617 5367020 SGTC_1143 3454-2408 5.08 µM -0.639716311053306 0.277856987234036 no 2441 0.261178524634902 3545 X1143 SGTC_1009 4106-0057 9.87 µM -0.640540511509309 0.2776040819579 no 2442 0.260910630192632 3609 2928005 SGTC_2840 9008771 71.43 µM -0.64059338063814 0.2775878629457 no 2443 0.26089345067132 3540 2992978 SGTC_2666 tannic acid 100 µM -0.642924100097817 0.276873313205701 no 2444 0.260136675300681 3604 16134267 A thiamine antagonist. SGTC_766 1391-0721 126 µM -0.643424575968679 0.276719995352962 no 2445 0.259974320473115 3599 1020919 YIL115C NUP159 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.648074906352274 0.275297386153572 no 2446 0.258468251624305 3596 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_919 tnp00227 403.569 nM -0.649070677214659 0.274993232768079 no 2447 0.258146347006712 3602 1269246 A methoxyflavone. YNL221C POP1 SGTC_2825 7998094 58.44 µM -0.650850732876944 0.274449936214049 no 2448 0.257571423589059 3556 2987815 SGTC_1246 0422-0085 105 µM -0.651651736760674 0.274205632158016 no 2449 0.257312931998526 3607 264295 SGTC_940 3232-1287 54.8 µM -0.651715167512885 0.274186290537577 no 2450 0.257292468052644 3577 1585493 YIL048W NEO1 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.652130161499106 0.274059765135978 no 2451 0.257158604112572 3603 688761 SGTC_2307 7538926 6.34 µM -0.653483374825868 0.273647391341887 no 2452 0.25672235197651 3590 96582 SGTC_2277 7947813 106.88 µM -0.655340167741784 0.273082058433989 no 2453 0.256124382301962 3665 1246798 SGTC_2987 9018338 71.43 µM -0.655570983836905 0.27301182293124 no 2454 0.256050100074156 3654 5055682 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.656398406027498 0.272760118552232 no 2455 0.255783907884902 3616 5106787 A p450 inhibitor. SGTC_1322 1348-1070 12 µM -0.656990206590843 0.272580161648396 no 2456 0.255593606805877 3597 6758089 SGTC_619 1652-1634 108 µM -0.658422520526178 0.272144862424627 no 2457 0.255133334105821 3554 5400454 SGTC_334 1502-1024 68.5 µM -0.658568616505186 0.272100481345374 no 2458 0.255086410679043 3626 3296216 SGTC_1610 st001799 48.1 µM -0.660336095389735 0.271563841356754 no 2459 0.254519085788089 3543 621897 SGTC_7 0192-1582 4.227 µM -0.660844786353556 0.271409490900265 no 2460 0.254355928893096 3651 252616 SGTC_1141 3253-0389 52.6 µM -0.661044107501141 0.271349023449164 no 2461 0.254292013833004 3593 5402031 SGTC_2118 5526350 200 µM -0.664020007335568 0.270447032885134 no 2462 0.253338752932455 3609 743594 SGTC_2420 aureobasidin a 50 nM -0.664146114801677 0.270408843027873 no 2463 0.253298398842179 3671 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2100 5377183 190 µM -0.665170107056027 0.270098841330581 no 2464 0.25297084891867 3641 2844202 SGTC_2156 5649887 115 µM -0.665195495459358 0.27009115754719 no 2465 0.252962730625793 3658 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3298 9116858 71.43 µM -0.665359843837837 0.270041420264996 no 2466 0.252910181276685 3635 2506942 SGTC_3006 9075424 71.4286 µM -0.665459231143016 0.270011344586668 no 2467 0.252878405605775 3602 7465181 SGTC_2045 5106652 78.05 µM -0.665520810424304 0.269992710868161 no 2468 0.25285871880393 3603 673349 SGTC_3106 9121286 49.47 µM -0.66559814167105 0.269969311560422 no 2469 0.252833997265634 3651 15943471 SGTC_463 ikarugamyin 104 µM -0.666600623550396 0.269666067047139 no 2470 0.25251363535313 3660 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2748 diazoxide 86.69 µM -0.666990632410959 0.26954813792071 no 2471 0.252389058512818 3559 3019 A potassium channel activatior. SGTC_859 0439-0102 54.6 µM -0.668539421861489 0.26908007716579 no 2472 0.251894663286397 3642 610143 SGTC_517 1365-0151 113 µM -0.670032112135292 0.268629356491885 no 2473 0.251418659875305 3662 768657 SGTC_3142 9086498 49.47 µM -0.671044530816763 0.268323870817549 no 2474 0.251096080863471 3574 25236367 SGTC_380 3970-0968 6 µM -0.674490759476595 0.267285322485962 no 2475 0.249999679274407 3601 2891601 SGTC_2047 4141938 200 µM -0.674490759476595 0.267285322485962 no 2476 0.249999679274407 3611 3807862 SGTC_3090 9117696 49.47 µM -0.674933301262093 0.267152106113494 no 2477 0.249859070949023 3604 7923821 SGTC_1135 dihydrocapsaicin 536.708 nM -0.675135614166736 0.267091215931063 no 2478 0.249794804273065 3604 107982 A Capsaicinoid. SGTC_2089 5281248 129.67 µM -0.676306408434807 0.266738979252006 no 2479 0.249423062426594 3647 2737878 SGTC_216 k038-0035 28.382 µM -0.677207444648965 0.266468059990782 no 2480 0.249137172481401 3578 4444231 YPR107C YTH1 SGTC_454 lyso-paf C-16 6.67 µM -0.67814599622549 0.266186008870189 no 2481 0.248839564718066 3580 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_691 1548-0686 185 µM -0.678360983211831 0.26612142281347 no 2482 0.248771420585044 3621 46495133 SGTC_1501 4491-0275 38.4 µM -0.679144268604604 0.265886176575352 no 2483 0.248523227749846 3629 5104718 SGTC_602 3130-1533 38.1 µM -0.679729697722994 0.265710421889655 no 2484 0.2483378141015 3653 720941 SGTC_1947 st076332 61.6 µM -0.680670165910487 0.265428202469049 no 2485 0.248040109032097 3627 24208416 SGTC_3063 1327-0034 4 µM -0.683823639037846 0.264483007154425 no 2486 0.247043268776666 3577 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2006 4011487 200 µM -0.684366836138746 0.264320366959031 no 2487 0.246871776102002 3683 45595294 SGTC_1937 st074714 47.2 µM -0.68444317908992 0.264297512979758 no 2488 0.246847678988435 3619 17250970 SGTC_2059 5238311 157 µM -0.684741101081509 0.264208336859358 no 2489 0.246753654059858 3654 703021 SGTC_735 3076-0345 636 µM -0.685406199150527 0.26400931030213 no 2490 0.246543816647084 3677 2888990 SGTC_644 1498-1197 63.3 µM -0.686313603478343 0.263737898347384 no 2491 0.246257686237862 3675 6741615 SGTC_1194 1488-0194 225 µM -0.686463480328105 0.263693082669916 no 2492 0.246210442939684 3624 1391452 SGTC_1338 1486-1223 76 µM -0.686511816647111 0.263678630132898 no 2493 0.246195207686279 3674 3444526 SGTC_1944 st076371 56.9 µM -0.687017540593385 0.263527443140188 no 2494 0.246035837524346 3653 24208455 SGTC_2273 7815444 169.05 µM -0.687595228107475 0.263354796668736 no 2495 0.245853857028456 3619 2824616 SGTC_996 3970-0799 1.8 µM -0.688243365826026 0.263161164367416 no 2496 0.245649769659694 3725 6615648 YGL040C HEM2 SGTC_3232 9132874 49.47 µM -0.688413754667598 0.263110272473327 no 2497 0.245596132264774 3649 3784940 SGTC_1462 k081-0014 26.5 µM -0.690289912250833 0.262550232759479 no 2498 0.245005945203114 3463 3270634 SGTC_2447 5741742 33.78 µM -0.691688465535042 0.262133156905109 no 2499 0.244566496054545 3699 1776504 SGTC_492 tmb-8 126 µM -0.693173389996367 0.261690695404553 no 2500 0.244100372701009 3559 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1172 0370-0043 85 µM -0.693327976210821 0.26164465553419 no 2501 0.244051875059188 3686 376585 SGTC_1976 st070609 63.5 µM -0.694788345124998 0.261209924195702 no 2502 0.243593976616224 3614 682556 SGTC_349 k015-0014 24 µM -0.695215305846419 0.261082894136243 no 2503 0.243460190856047 3646 2196908 SGTC_2365 9042475 200 µM -0.695319762375173 0.261051820892815 no 2504 0.243427466030313 3693 6464479 SGTC_2920 7982904 15.77 µM -0.695585295733726 0.260972839821857 no 2505 0.24334428870052 3650 6456808 SGTC_33 0986-0033 35.816 µM -0.695642564999466 0.260955807083688 no 2506 0.243326351331311 3612 2848082 SGTC_2148 5546263 113.568 µM -0.697467962583325 0.260413206134606 no 2507 0.24275499110838 3673 792097 SGTC_1030 k029-0042 36.7 µM -0.698433188999095 0.260126526835893 no 2508 0.242453163311626 3682 6080581 SGTC_1385 3091-4834 14.1 µM -0.701694494508998 0.259159100159009 no 2509 0.241434853578941 3646 4072814 SGTC_1961 st076550 68.7 µM -0.703641419797261 0.258582456291708 no 2510 0.240828055009623 3655 1579337 SGTC_2103 5378138 10 µM -0.704877670523221 0.258216646490055 no 2511 0.240443183648544 3724 244142 SGTC_2913 7966556 36.57 µM -0.704893637440457 0.258211923593109 no 2512 0.240438214997005 3613 2976516 SGTC_1348 1493-0373 93.8 µM -0.705240157439418 0.258109436552787 no 2513 0.24033039724359 3671 3010129 SGTC_3293 9120939 62.045 µM -0.705291206524218 0.258094340016209 no 2514 0.240314515833593 3676 934087 SGTC_722 3534-0461 190 µM -0.705894906527618 0.257915845019772 no 2515 0.24012674766241 3667 658262 SGTC_1015 4130-4525 82 µM -0.705965760982834 0.257894899798812 no 2516 0.240104715121448 3691 1363237 SGTC_545 4218-0007 221 µM -0.707520227525109 0.25743560753099 no 2517 0.239621623517168 3638 2840508 SGTC_1615 st002656 86.5 µM -0.708163109296866 0.257245782016897 no 2518 0.239421986184855 3700 1584458 SGTC_3263 9137018 49.47 µM -0.70837631826517 0.257182843274335 no 2519 0.239355797387211 3644 43844957 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.708422937089825 0.257169082583198 no 2520 0.239341326326058 3691 689007 SGTC_145 3737-0113 38.366 µM -0.709244985226157 0.256926497791568 no 2521 0.239086230920687 3712 6849351 SGTC_851 0394-0702 453 µM -0.709435499947302 0.256870294270169 no 2522 0.239027132207889 3676 762646 SGTC_2384 9036245 200 µM -0.709465556302154 0.25686142796501 no 2523 0.239017809290956 3698 6462766 SGTC_1558 st069300 45.6 µM -0.710231151384348 0.25663563926131 no 2524 0.238780403107453 3641 24208000 SGTC_2817 7995342 71.43 µM -0.710781721520032 0.256473329459385 no 2525 0.23860975456843 3680 18879975 SGTC_1226 3909-7979 35.4 µM -0.710976075307817 0.256416046127952 no 2526 0.238549530793392 3708 6615510 SGTC_2482 5981709 142.65 µM -0.712197053356187 0.256056330780862 no 2527 0.238171380691251 3684 877755 SGTC_1039 k821-0043 94 µM -0.716020401452354 0.254931629756222 no 2528 0.236989375826406 3658 15992768 SGTC_1398 3558-0053 112 µM -0.716260887950935 0.254860973195407 no 2529 0.236915136300452 3625 4532369 SGTC_732 3970-1727 52.7 µM -0.716498549441554 0.254791156712349 no 2530 0.236841781432543 3707 1275699 SGTC_817 1391-0715 46 µM -0.716602752613267 0.254760548688733 no 2531 0.236809622777701 3686 1353946 SGTC_3212 9128307 49.47 µM -0.718003752890168 0.254349214158617 no 2532 0.236377486414986 3684 27243542 SGTC_790 1575-0012 79.1 µM -0.72095290337181 0.253484480813281 no 2533 0.235469245929668 3775 378741 YLR208W SEC13 SGTC_1630 st005209 31.3 µM -0.72126298141971 0.253393651303152 no 2534 0.235373864188689 3692 3367314 SGTC_615 k087-0205 167 µM -0.723525920426825 0.252731298947062 no 2535 0.234678417618359 3712 9642773 SGTC_624 k048-0052 28 µM -0.725416081179843 0.252178756738917 no 2536 0.234098405243367 3692 6835531 SGTC_425 3825-7017 13.1 µM -0.726893249736299 0.251747386606126 no 2537 0.233645676329791 3799 3397440 SGTC_3125 9127534 49.47 µM -0.726953348892909 0.251729844402992 no 2538 0.233627267166723 3582 1639235 SGTC_2329 6138490 200 µM -0.727623045953104 0.251534411765176 no 2539 0.233422184559895 3774 720019 SGTC_1862 st057513 3.81 µM -0.728643605141934 0.251236743918167 no 2540 0.233109848926733 3700 5393163 SGTC_1897 st060201 15 µM -0.728706599140199 0.251218376481214 no 2541 0.233090577621372 3761 611878 SGTC_3034 9090421 49.47 µM -0.729239100997877 0.25106314095098 no 2542 0.232927708467841 3642 17173761 SGTC_2088 5278280 127.392 µM -0.732157478511163 0.250213274334476 no 2543 0.232036227221713 3785 791502 SGTC_1271 0832-2808 169 µM -0.732443066190124 0.250130189799782 no 2544 0.231949090472957 3757 3663794 SGTC_2426 5582046 32.21 µM -0.732644395846541 0.250071626808222 no 2545 0.231887672964203 3717 2251934 SGTC_1102 cgs 12066b 26.1 µM -0.732728573224286 0.250047143356836 no 2546 0.231861996547396 3729 6438352 A 5-HT1B full agonist. SGTC_1970 st070122 35.8 µM -0.733054973855826 0.249952219973221 no 2547 0.231762450348509 3733 102928 SGTC_1768 st044301 37.178 µM -0.733513500986045 0.249818904052121 no 2548 0.231622648222393 3738 3931349 SGTC_1665 st014639 11.4 µM -0.733833871951486 0.249725779189417 no 2549 0.23152499696663 3791 981133 YIL048W NEO1 SGTC_196 k015-0023 18.111 µM -0.733969261642924 0.249686429896686 no 2550 0.231483736165048 3714 5211998 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.734603567884166 0.249502120712739 no 2551 0.231290482228445 3742 521171 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.737308678862872 0.248716913905706 no 2552 0.230467327789296 3748 6708739 YPR165W RHO1 SGTC_2011 4012611 177 µM -0.738773680231735 0.248292221035766 no 2553 0.230022218213074 3763 2049887 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.738841830313603 0.248272474255479 no 2554 0.230001523973574 3753 688751 SGTC_1275 0867-0008 21.1 µM -0.739359729657893 0.248122438050162 no 2555 0.22984429433739 3732 3422836 SGTC_3152 9099253 49.47 µM -0.739438586179795 0.24809959744261 no 2556 0.229820359478385 3713 25236131 SGTC_1500 4488-1866 171 µM -0.740498524036897 0.247792697802463 no 2557 0.229498778215204 3815 2900003 SGTC_1594 piperine 70.1 µM -0.741635504194706 0.247463716405749 no 2558 0.229154103083886 3726 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1228 0124-0032 52.5 µM -0.741639603534147 0.247462530698046 no 2559 0.229152860896079 3794 X1228 SGTC_2411 st077133 39.94 µM -0.742785526500028 0.247131198885882 no 2560 0.228805769764879 3845 1403142 YNL221C POP1 SGTC_753 1322-0200 289 µM -0.744011537942538 0.246776973219233 no 2561 0.228434747453391 3763 5403907 SGTC_1014 4130-3005 69.3 µM -0.744820293913311 0.24654345208297 no 2562 0.228190182445332 3762 743608 SGTC_1807 st050092 58.9 µM -0.74483730487029 0.246538541591057 no 2563 0.228185039971977 3749 5008496 SGTC_2820 7989630 71.43 µM -0.745571403144695 0.246326682005394 no 2564 0.22796318151426 3630 2984098 SGTC_2970 9090938 41.86 µM -0.745583882862585 0.246323081222638 no 2565 0.227959410955459 3737 17217104 SGTC_1706 st031321 9.9705 µM -0.746053207634602 0.246187687064739 no 2566 0.227817637015358 3757 6103185 SGTC_3219 9131112 49.47 µM -0.746059429756038 0.246185892330855 no 2567 0.227815757766099 3707 17612988 YMR079W SEC14 SGTC_2206 7254556 146.969 µM -0.748952631805463 0.245352126070492 no 2568 0.226942877998404 3759 4398905 SGTC_2914 7968218 45.32 µM -0.749283078927399 0.245256994107697 no 2569 0.226843302181142 3737 2977111 SGTC_2084 5306078 60.6385 µM -0.750089339718612 0.245024964052429 no 2570 0.226600449744764 3690 679340 SGTC_1253 0550-0034 176 µM -0.7513426529467 0.244664513435987 no 2571 0.226223232943878 3750 5969915 SGTC_2790 5423970 71.43 µM -0.752290089216406 0.24439222210146 no 2572 0.225938313298124 3806 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_932 2857-0803 154 µM -0.753665974609285 0.243997086274502 no 2573 0.225524908935869 3867 674898 SGTC_2183 6420625 130.508 µM -0.754996679789166 0.243615253688755 no 2574 0.225125487196111 3773 2897619 SGTC_3002 9075603 71.4286 µM -0.755041134341655 0.243602503470329 no 2575 0.225112150730394 3737 20105405 SGTC_1529 apigenin 74 µM -0.755574340730262 0.243449600136277 no 2576 0.224952222501948 3793 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3170 9103054 49.47 µM -0.756116368453366 0.243294220338575 no 2577 0.224789714456452 3750 16432970 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.757571416803732 0.242877375663269 no 2578 0.224353798484562 3748 77254 SGTC_1606 st000094 49.2 µM -0.757587609245565 0.242872739000772 no 2579 0.224348950113974 3776 1242210 SGTC_3321 9137793 26.8275 µM -0.757875290983698 0.24279037008813 no 2580 0.224262821836518 3743 4904192 SGTC_1762 st045503 25.4615 µM -0.757988120308106 0.242758068972204 no 2581 0.224229047288393 3840 4645554 SGTC_576 1073-0113 22.7 µM -0.758566804163187 0.242592438194273 no 2582 0.224055868344862 3915 5439563 SGTC_1310 1188-0297 994 nM -0.759845573343409 0.242226646261826 no 2583 0.223673449012301 3696 1588352 SGTC_2383 9036125 200 µM -0.760648613172526 0.241997089625605 no 2584 0.223433487643474 3698 79580 SGTC_1222 0366-0074 1.18 µM -0.762070734548089 0.241590852260834 no 2585 0.223008894195908 3820 286520 SGTC_864 0469-0573 172 µM -0.762395646443082 0.241498091249772 no 2586 0.222911951911059 3757 689425 SGTC_3027 9089541 49.47 µM -0.76250115748185 0.241467972442928 no 2587 0.222880476291494 3756 9943819 SGTC_937 3122-0005 46.7 µM -0.762700615823485 0.241411041346638 no 2588 0.222820981616622 3803 759535 SGTC_773 4358-1457 44.6 µM -0.762926640875556 0.241346536167987 no 2589 0.222753573529809 3761 1186886 SGTC_2866 9034245 58.44 µM -0.763699699649156 0.24112598410963 no 2590 0.222523109905639 3763 6462273 SGTC_3261 9137475 49.47 µM -0.764052722930875 0.241025303757316 no 2591 0.22241791214218 3675 17027690 SGTC_2150 5556613 200 µM -0.764311193272362 0.240951603896267 no 2592 0.222340908294742 3781 743190 SGTC_1186 1319-0216 26 µM -0.765257282512692 0.240681941946153 no 2593 0.222059177810292 3844 4565136 SGTC_2640 pentamidine 10.38 µM -0.765670405761211 0.240564241786066 no 2594 0.221936220160369 3802 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2027 5150920 200 µM -0.767097485631773 0.24015790328874 no 2595 0.221511778382159 3748 786715 SGTC_2215 7188065 200 µM -0.768552959677279 0.239743865629727 no 2596 0.221079369954798 3771 940217 SGTC_844 0330-0132 15.3 µM -0.769289194648294 0.239534577828046 no 2597 0.22086082516788 3810 2828079 SGTC_2291 7917025 104.35 µM -0.769781135158757 0.239394790654437 no 2598 0.220714865976264 3740 2964612 SGTC_2507 purpurin 79.67 µM -0.770054234856648 0.239317207347495 no 2599 0.220633860904511 3800 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2625 euphol 100 µM -0.773066113697595 0.238462491864402 no 2600 0.219741627176454 3777 6708538 A triterpene alcohol. SGTC_3015 9080845 49.47 µM -0.77644082828104 0.23750679912923 no 2601 0.21874437284063 3868 5296973 SGTC_2227 7312221 64.1025 µM -0.776487002713753 0.23749373748708 no 2602 0.218730746024833 3819 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_103 0844-0104 51.839 µM -0.777478454893348 0.237213374535518 no 2603 0.218438270470992 3788 5375804 SGTC_1343 1487-0095 224 µM -0.779630892962589 0.236605334149258 no 2604 0.217804083279894 3770 4560101 YGL055W OLE1 SGTC_1468 k284-1086 134 µM -0.780811855973307 0.236272089574812 no 2605 0.217456579951569 3793 15996457 SGTC_77 0828-0286 12.516 µM -0.781399779900891 0.23610628539771 no 2606 0.217283700268934 3762 745345 SGTC_569 4130-2812 160 µM -0.782538658240052 0.235785285479314 no 2607 0.216949037735897 3664 743552 SGTC_960 1222-0186 7.7 µM -0.782785292001648 0.235715801935805 no 2608 0.216876602992037 3842 3126296 SGTC_2870 9038528 12.99 µM -0.783222792068273 0.235592573867716 no 2609 0.216748146449486 3812 6463316 SGTC_1489 4065-0444 182 µM -0.783872258436676 0.235409708052885 no 2610 0.216557534601298 3757 2877968 SGTC_3328 9140624 29.0385 µM -0.784120043634338 0.235339961515641 no 2611 0.216484837703251 3814 4904392 SGTC_223 busulfan 5 mM -0.784290270328209 0.23529205274423 no 2612 0.216434903627808 3812 2478 A DNA alkylator. SGTC_294 k038-0071 157 µM -0.784492442218456 0.235235160280223 no 2613 0.216375607450305 3825 24152826 SGTC_588 3970-1144 52.9 µM -0.7846219001102 0.235198733990314 no 2614 0.216337642925835 3747 1888707 SGTC_1078 idebenone 36.1 µM -0.786614404206184 0.234638485061243 no 2615 0.215753812292511 3877 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2746 daunorubicin 9.88 µM -0.786680318351329 0.234619964052983 no 2616 0.215734514176111 3699 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3068 9116768 49.47 µM -0.789015838838416 0.233964235615976 no 2617 0.215051374641703 3769 41904888 SGTC_1901 st060216 58.6 µM -0.791374373032226 0.233303077384313 no 2618 0.214362779959843 3812 688792 SGTC_3215 9129942 49.47 µM -0.792244410727989 0.233059445310984 no 2619 0.214109088973374 3760 17682944 SGTC_1344 1488-0097 29.1 µM -0.792928737865612 0.232867916088462 no 2620 0.213909671437806 3857 747966 SGTC_3133 9127736 49.47 µM -0.794782095367895 0.232349638450768 no 2621 0.213370133910382 3787 27243420 SGTC_352 k048-0007 5.11 µM -0.795431728784674 0.232168125292397 no 2622 0.213181204739209 3852 6811911 SGTC_2858 9025781 8.96 µM -0.79600893366618 0.232006915522218 no 2623 0.213013421429615 3801 4894980 YPL153C RAD53 SGTC_1525 8-methoxypsoralen 92.5 µM -0.796079207450168 0.231987292743774 no 2624 0.212992999338788 3821 4114 Related to psoralen; DNA damaging agent. SGTC_475 α-linolenic acid 10 µM -0.797413046177392 0.231615015877747 no 2625 0.212605592435845 3856 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1131 3454-3128 32.3 µM -0.798042187826347 0.23143953690424 no 2626 0.212423004259618 3906 710982 SGTC_2940 9060638 45.86 µM -0.798836654366715 0.231218051780882 no 2627 0.212192566783191 3844 4027022 SGTC_2851 9015922 71.43 µM -0.799032504092866 0.231163470046528 no 2628 0.212135782425381 3821 2996893 SGTC_2708 st078559 56 µM -0.800732001448745 0.230690135876372 no 2629 0.211643406043617 3799 17250902 SGTC_793 0488-0545 106 µM -0.800875386023389 0.230650226017545 no 2630 0.211601895454996 3829 292548 SGTC_1746 st038117 42 µM -0.802251423118551 0.23026741418332 no 2631 0.211203767889744 3902 2898218 SGTC_1051 3253-3903 78 µM -0.804116860393312 0.22974901965583 no 2632 0.21066474404929 3827 5509239 SGTC_1214 0358-0031 63.7 µM -0.805909961131952 0.229251343672101 no 2633 0.210147383623407 3994 4301366 SGTC_160 3453-0671 289.699 µM -0.808076616108127 0.228650794835529 no 2634 0.209523239014709 3880 5322268 SGTC_1426 4048-4480 71.7 µM -0.808467146616428 0.228542642464025 no 2635 0.209410855659634 3813 14224343 SGTC_3291 9121177 71.43 µM -0.809538658005703 0.228246048878762 no 2636 0.209102687980863 3855 17015612 SGTC_1877 wortmannin 25 µM -0.81021456057281 0.228059070876828 no 2637 0.208908435194518 3845 312145 A covalent inhibitor of PI 3-kinase. SGTC_692 k241-0027 77.8 µM -0.811359147288782 0.227742635188564 no 2638 0.208579726250386 3875 3600480 SGTC_67 0335-0847 266 µM -0.812753868021726 0.227357380992978 no 2639 0.208179594833184 4019 4552207 YOR254C SEC63 SGTC_1379 2144-0755 36.5 µM -0.813109219296263 0.227259283457617 no 2640 0.208077720561375 3924 5392327 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.817218637389085 0.226126580368784 no 2641 0.206901746784193 3832 390807 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.817618154562618 0.226016629527476 no 2642 0.206787628921292 3892 165506 SGTC_80 0159-0065 512.242 µM -0.818616959181738 0.225741881472554 no 2643 0.206502494002454 3767 1548079 SGTC_98 0074-0023 107.663 µM -0.819323317646435 0.225547692697845 no 2644 0.206300986167225 3827 3563821 SGTC_63 0099-0242 26.702 µM -0.821561241638127 0.224933077726089 no 2645 0.205663327868992 3900 3898502 YLR359W ADE13 SGTC_1849 st056239 19.2 µM -0.823029651899266 0.224530315437195 no 2646 0.205245565750345 3864 5393181 SGTC_799 1310-0557 151 µM -0.823264750834609 0.224465869447323 no 2647 0.205178727051588 3959 5354492 SGTC_2314 7727897 200 µM -0.82394494137728 0.224279472808666 no 2648 0.204985421528572 3880 900724 SGTC_396 dithiazanine 1.25 µM -0.824170812690475 0.224217595397738 no 2649 0.204921254391231 3859 10578 An antihelmenthic. SGTC_1342 1486-1464 234 µM -0.825689683546265 0.223801752813227 no 2650 0.204490072958686 3894 3253938 SGTC_2052 5265182 7.135 µM -0.825998056721286 0.223717378731473 no 2651 0.204402597080858 3886 1239884 SGTC_1346 1488-2224 62.4 µM -0.826988487632161 0.223446508970703 no 2652 0.204121793338007 3824 3722427 SGTC_2477 5967686 25.23 µM -0.827834278452656 0.223215344135134 no 2653 0.203882179473225 3870 776118 SGTC_2602 kawain 100 µM -0.828127938453371 0.223135115163463 no 2654 0.203799024356015 3817 5369129 SGTC_840 0245-0196 390 µM -0.829438874570927 0.222777162989895 no 2655 0.203428055827033 3975 3827528 SGTC_1473 k844-0725 134 µM -0.830176725249044 0.2225758362666 no 2656 0.203219436239465 3927 54682906 SGTC_1811 st050069 61.5 µM -0.831813351950915 0.22212964385243 no 2657 0.20275715309573 3814 3877702 SGTC_2741 miltefosine 3.04 µM -0.831991965863772 0.222080979382046 no 2658 0.202706739695648 3828 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_3271 9137798 49.47 µM -0.834509073362731 0.221395825319395 no 2659 0.201997088287335 3779 6498326 SGTC_1497 4476-2978 41.3 µM -0.836714532190498 0.220796496420022 no 2660 0.201376524304335 3920 1528379 SGTC_2362 9071156 126 µM -0.836719765667665 0.220795075339165 no 2661 0.201375053087878 3915 653133 SGTC_557 1315-0110 16.2 µM -0.837017493562806 0.220714239928625 no 2662 0.201291367491208 3876 6833801 SGTC_1672 st016598 6.51 µM -0.838657863873694 0.220269170868272 no 2663 0.200830664879883 3924 4665860 YNL267W PIK1 SGTC_1075 aripiprazole 15.2 µM -0.838825835862026 0.220223625383141 no 2664 0.200783525216794 3915 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1753 st043925 64 µM -0.839035762286762 0.220166711575185 no 2665 0.200724620796553 3940 670181 SGTC_596 1155-0152 116 µM -0.84034937627349 0.21981076518939 no 2666 0.200356262157435 3880 280313 SGTC_154 3389-1638 511.116 µM -0.84057979108709 0.21974836438735 no 2667 0.20029169200097 3887 5238686 SGTC_2186 6124449 200 µM -0.841412788574939 0.219522857366324 no 2668 0.200058361780614 3882 3834182 YLR033W RSC58 SGTC_1968 st069590 43.6 µM -0.842596951185966 0.219202512702092 no 2669 0.199726948394848 3899 6384066 SGTC_2395 5646831 180.19 µM -0.843722282451862 0.218898332529599 no 2670 0.199412306512172 3914 6808628 SGTC_1054 3429-0080 167 µM -0.845494441376417 0.218419805684496 no 2671 0.198917417459977 3912 1162877 SGTC_2839 9003951 25.97 µM -0.845940079868357 0.218299567115572 no 2672 0.198793086046564 3944 2990634 SGTC_1984 st072354 53.1 µM -0.847608907141246 0.217849636584148 no 2673 0.198327906087499 3801 5762938 SGTC_1791 st048313 56.1 µM -0.848685991518948 0.217559529363461 no 2674 0.198028021580297 3871 1204976 SGTC_2367 9070478 135.38 µM -0.850581643350538 0.217049487063436 no 2675 0.197500895033685 3858 572802 SGTC_3260 9137109 49.47 µM -0.854251613451522 0.21606401457667 no 2676 0.19648279541118 3814 17478346 SGTC_2745 rifampicin 24.3 µM -0.857119092427734 0.215295836468518 no 2677 0.195689535297025 3900 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_174 3553-0389 74.3 µM -0.85969896009386 0.214606063825404 no 2678 0.194977504083237 3954 738071 SGTC_3049 9092223 49.47 µM -0.860273664045926 0.214452581822748 no 2679 0.194819103323296 3900 8623917 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.860543366033775 0.214380576485479 no 2680 0.19474479465134 3938 551469 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.86114839017578 0.214219097624932 no 2681 0.194578160281287 3903 7104 SGTC_2902 5787006 60.46 µM -0.86221414121143 0.213934824518863 no 2682 0.194284844676079 3883 591003 SGTC_353 1988-1175 58.3 µM -0.862701072671762 0.213805015982238 no 2683 0.194150921238271 3764 2788357 SGTC_1734 st037168 69.4 µM -0.864990608783669 0.213195275598916 no 2684 0.193521971656133 3987 708907 SGTC_2229 7354935 190 µM -0.866931535649242 0.21267917064596 no 2685 0.192989761712724 3844 318112 SGTC_2502 avocadyne acetate 18.59 µM -0.867529027692589 0.212520440641492 no 2686 0.192826107089779 3868 3952079 SGTC_509 pifithrin 175 µM -0.868346464464136 0.212303392158533 no 2687 0.192602346418138 3963 4817 A p53 inhibitor. SGTC_1641 st009299 47.1 µM -0.86973414723085 0.211935226886054 no 2688 0.192222853292935 3850 4046054 SGTC_2680 butyl paraben 22.24 µM -0.871116272289327 0.21156890760944 no 2689 0.191845335041465 3981 7184 An antifungal and steroid mimetic. SGTC_2303 7774051 200 µM -0.871262128325772 0.211530271470821 no 2690 0.191805521932116 3900 2953184 SGTC_1658 st012944 20 µM -0.873093522856497 0.211045500880029 no 2691 0.191306052026176 3832 24207260 SGTC_3335 9143315 29.6265 µM -0.873668773729572 0.210893366333919 no 2692 0.191149330518297 3935 4899691 SGTC_2892 9047358 58.44 µM -0.874271222356695 0.210734107854772 no 2693 0.190985283664644 3935 6466771 SGTC_2544 sphondin 68.51 µM -0.874753903104663 0.210606561169092 no 2694 0.19085391195135 3903 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1136 pergolide 1.05886 µM -0.875434681434652 0.210426744915076 no 2695 0.190668718085736 3920 47811 A dopamine receptor agonist. SGTC_1932 st074806 40.9 µM -0.875571597051548 0.21039059182424 no 2696 0.190631485907482 4017 17251235 SGTC_2184 6075246 200 µM -0.876642800630618 0.210107862328737 no 2697 0.19034034199798 3969 2267320 SGTC_952 1185-0122 232 µM -0.876850653625462 0.210053028248517 no 2698 0.190283880998287 3870 678600 SGTC_1184 1269-1718 139 µM -0.877653033979666 0.209841429705558 no 2699 0.190066019656312 4009 5403821 SGTC_1952 st077036 64.1 µM -0.877922462726543 0.209770405814052 no 2700 0.189992899083143 3938 2937007 SGTC_711 k292-0785 179 µM -0.87850490557584 0.209616916839701 no 2701 0.189834888360765 3914 4146315 SGTC_3323 9138564 53.9225 µM -0.878603372812719 0.209590974667746 no 2702 0.189808183204874 3962 43912313 YNL103W MET4 SGTC_2791 5663188 71.43 µM -0.879180613511676 0.209438932857301 no 2703 0.189651677066627 3970 54690634 SGTC_370 0180-0345 38.7 µM -0.879213748137769 0.209430207361251 no 2704 0.189642695750204 3827 3989527 SGTC_2565 isoliquiritigenin 100 µM -0.879727328841967 0.209294991105036 no 2705 0.189503520430357 4034 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_366 0181-0206 4.31 µM -0.882243506668463 0.208633271170651 no 2706 0.188822569636262 3921 274874 SGTC_993 3909-8757 62.7 µM -0.882246783950687 0.208632410095788 no 2707 0.188821683692933 3914 4288324 YLR208W SEC13 SGTC_356 1634-0012 32.5 µM -0.882706351427979 0.20851168383943 no 2708 0.188697474796232 3939 735457 SGTC_2952 9073731 13.78 µM -0.885319706205587 0.20782595112961 no 2709 0.187992112252252 4023 16457353 SGTC_175 3793-3120 23.7 µM -0.888014206638002 0.20712032260505 no 2710 0.187266554731 3967 5322297 SGTC_3207 9114163 49.47 µM -0.88874312516032 0.206929679218082 no 2711 0.187070574244713 3979 849233 SGTC_408 cantharidin 100 µM -0.88947135784939 0.206739318948209 no 2712 0.186874904894943 3916 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2288 7946289 167.31 µM -0.890438129116678 0.206486764866706 no 2713 0.186615338204643 4004 1246052 SGTC_1393 3470-5649 58.2 µM -0.890658580169787 0.20642920103054 no 2714 0.186556180965491 3930 4108395 SGTC_3112 9123419 49.47 µM -0.891135267122121 0.206304761787685 no 2715 0.186428303463297 3992 17015854 SGTC_2521 angolensin 13.4 µM -0.891704845050411 0.20615613164632 no 2716 0.186275577959739 4036 821428 A flavenoid. SGTC_501 nsc-95397 161 µM -0.893053944053701 0.205804340511668 no 2717 0.185914142604081 4006 262093 SGTC_2133 5320837 200 µM -0.893991885669171 0.205559972839322 no 2718 0.185663116342079 3997 2841355 SGTC_2908 7930301 100 µM -0.894859909370896 0.205333974860847 no 2719 0.185430990037953 3943 2223178 SGTC_3157 9099274 49.47 µM -0.894903883176273 0.205322529804091 no 2720 0.185419235389364 3952 17217662 SGTC_2438 5259590 200 µM -0.895143851242994 0.205260080022327 no 2721 0.185355097616922 3981 1201127 SGTC_2812 7970281 58.44 µM -0.895405675105095 0.205191955318087 no 2722 0.185285134023621 4021 2233435 SGTC_1926 methyl fluorone black 53.6 µM -0.897197877512193 0.204725997852079 no 2723 0.184806668794941 3728 72721 Reacts with homocysteine. SGTC_2997 9067075 71.4286 µM -0.897296608607413 0.204700346907001 no 2724 0.184780332840258 3988 27209819 SGTC_2111 5486399 200 µM -0.897730674932695 0.20458759649028 no 2725 0.184664575808304 3927 689674 SGTC_983 1491-0821 12.2 µM -0.898401983922906 0.204413294153358 no 2726 0.184485639589962 3983 46495113 SGTC_2180 6301957 200 µM -0.898424444759812 0.2044074638275 no 2727 0.18447965455892 3966 845462 SGTC_3281 9140613 49.47 µM -0.899783562148742 0.20405485190522 no 2728 0.184117721875598 3992 16013766 SGTC_2965 9082772 38.63 µM -0.900105189820287 0.203971461282308 no 2729 0.184032137212044 3984 16459634 SGTC_2802 7925815 54.55 µM -0.90162464237759 0.203577776996492 no 2730 0.183628148054663 3947 1262923 SGTC_224 benfluorex 43.875 µM -0.903339504295656 0.203134007665909 no 2731 0.183172868179622 3974 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_930 2810-3379 265 µM -0.90383418250718 0.203006102999975 no 2732 0.18304166667474 4021 1015764 SGTC_2810 7959871 45.46 µM -0.906105495896977 0.202419446781662 no 2733 0.182440008329171 3954 2974535 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.908472339130987 0.201809196084346 no 2734 0.181814360766832 3938 2333 A French combination drug. SGTC_1002 4049-0206 172 µM -0.908811172270483 0.201721923893109 no 2735 0.181724904101823 3993 4662749 SGTC_3252 9135871 49.47 µM -0.909776358887267 0.20147344772507 no 2736 0.18147023237961 3997 17682838 SGTC_152 4469-0003 551.229 µM -0.90987101967652 0.201449088276038 no 2737 0.181445267456697 3904 697280 SGTC_262 fenpropimorph 62.5 µM -0.910272532489442 0.201345784959583 no 2738 0.181339400244642 3946 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1755 st041960 45.185 µM -0.912474751838914 0.200779751377815 no 2739 0.180759427331589 4056 2257073 SGTC_1690 st023502 41.2 µM -0.913964227515044 0.200397455365665 no 2740 0.180367821432316 3978 24207482 SGTC_2474 5321570 43.32 µM -0.919439065951726 0.198996018803461 no 2741 0.178932981813866 4012 2841384 SGTC_2085 5307070 144.047 µM -0.919608071328292 0.198952851375087 no 2742 0.178888803669369 3930 2840351 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.922313496037206 0.198262599093369 no 2743 0.178182538171753 3966 688803 SGTC_679 0422-0091 41.4 µM -0.922921473153596 0.198107681155548 no 2744 0.17802406470188 3971 627384 YHR062C RPP1 SGTC_738 1315-0003 72.4 µM -0.9231687338499 0.19804469785943 no 2745 0.177959639907461 4064 6251474 SGTC_1702 st027038 51 µM -0.92340377370163 0.19798483872059 no 2746 0.177898412936473 4018 5521182 SGTC_1120 ficusin 1.78878 µM -0.924942873375673 0.197593136244165 no 2747 0.177497811830658 4076 6199 A DNA cross-linker. SGTC_2876 9059903 25.97 µM -0.926208461031231 0.197271394108539 no 2748 0.177168828151369 3941 6916095 SGTC_1555 citronellol 128 µM -0.926312849243053 0.197244870326436 no 2749 0.177141710121334 3940 8842 A terpine precursor. SGTC_901 1112-0062 60.1 µM -0.928461736872677 0.196699343414235 no 2750 0.176584053471637 3997 1908457 SGTC_2286 7945697 125 µM -0.928910955647204 0.196585418178525 no 2751 0.176467617407317 4029 1245733 SGTC_2545 solidagenone 89.61 µM -0.929491185898926 0.196438326632474 no 2752 0.176317295482411 3798 6708572 An anti ulcer agent SGTC_2403 6032726 181.2 µM -0.929754087712305 0.196371701546742 no 2753 0.176249211432347 4065 2881040 SGTC_2237 6667747 47.222 µM -0.93066807948984 0.196140182586036 no 2754 0.176012643192389 4007 729940 YDL015C TSC13 SGTC_1652 st011932 78 µM -0.935395987044789 0.194945223546868 no 2755 0.174792132116226 3942 1551076 SGTC_2667 digitoxin 100 µM -0.936272919910921 0.19472407007065 no 2756 0.174566343589074 3943 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2284 7945075 39.21 µM -0.937621474217222 0.194384276472548 no 2757 0.174219485807035 4032 1245402 SGTC_1439 4092-1168 46 µM -0.93797199488395 0.194296015347334 no 2758 0.174129401157668 4033 2886240 SGTC_693 4161-2696 114 µM -0.939405768107395 0.193935245289274 no 2759 0.173761226324861 4049 805759 SGTC_610 4215-0184 155 µM -0.940606743040135 0.193633367001112 no 2760 0.173453212542649 4042 5605015 SGTC_1027 k015-0025 8.67 µM -0.940753487045191 0.193596500933533 no 2761 0.173415600979498 3998 3598955 SGTC_1198 1612-1005 86.7 µM -0.940881117374201 0.19356444021977 no 2762 0.173382892613062 4104 6998509 SGTC_1232 0279-0259 161 µM -0.941792589604713 0.193335572726089 no 2763 0.173149419936141 4033 1560000 SGTC_505 gw-5074 63.9 µM -0.942772853657881 0.193089616225734 no 2764 0.17289854988615 4073 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_705 1124-0212 310 µM -0.943154908799749 0.192993807136304 no 2765 0.172800836752917 3974 9554485 SGTC_379 3970-0972 5.9 µM -0.943456410933057 0.192918219059935 no 2766 0.172723750437443 4012 2898042 YBL034C STU1 SGTC_2129 girgensonine 121.053 µM -0.943597482657781 0.192882857891017 no 2767 0.172687689566717 4037 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3282 9108498 15.4605 µM -0.947884890486111 0.191810061657533 no 2768 0.171594028872405 4025 16459645 SGTC_336 4111-0029 111 µM -0.948084438014322 0.191760219959475 no 2769 0.171543234963223 4036 3131175 SGTC_459 nigericin 15.3 µM -0.948750380169302 0.191593942613844 no 2770 0.171373791980285 4095 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_683 panaxydol 45 µM -0.951159996599959 0.190993030104859 no 2771 0.170761581056629 4017 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_75 0159-0059 199.013 µM -0.952018267753609 0.190779273103849 no 2772 0.170543858711435 4122 5377270 SGTC_788 1182-0090 188 µM -0.952234794411464 0.190725369184952 no 2773 0.170488959297581 4088 5715185 SGTC_604 1000-0114 314 µM -0.955220170428953 0.189983118400709 no 2774 0.16973318380487 4040 1572745 SGTC_1297 1068-0111 14.1 µM -0.955748008729242 0.189852067507299 no 2775 0.169599780550279 3994 767057 SGTC_2480 5767542 37.17 µM -0.956570881693064 0.189647876755783 no 2776 0.169391945891608 3995 2867358 SGTC_2915 7971052 15.16 µM -0.958484523694023 0.189173541176643 no 2777 0.168909245904685 3943 5741558 SGTC_203 k066-0004 30.888 µM -0.958849777599251 0.189083088569675 no 2778 0.16881721422557 4120 6795412 SGTC_316 k060-0003 58.6 µM -0.959164884814205 0.189005075850583 no 2779 0.168737843716128 4060 6152314 SGTC_1996 st072960 66.8 µM -0.959750860356259 0.188860055588978 no 2780 0.168590309545736 4086 1719405 SGTC_1304 1165-0502 251 µM -0.959758338184669 0.188858205380459 no 2781 0.168588427349225 4050 767425 SGTC_2213 7173844 200 µM -0.960598339113835 0.188650438484755 no 2782 0.16837708205922 3990 892728 SGTC_3069 9117009 49.47 µM -0.962615377633702 0.188152117310808 no 2783 0.167870288766207 4012 41904981 SGTC_1852 st056254 31.4 µM -0.962698262486452 0.188131657514181 no 2784 0.167849484465741 3969 442583 SGTC_3064 1327-0027 10 µM -0.963702508979654 0.18788387237093 no 2785 0.16759754804589 3937 16000455 YPR107C YTH1 SGTC_2402 5553605 200 µM -0.963748020573587 0.187872647735087 no 2786 0.167586136274748 4145 6758546 SGTC_3081 9117243 49.47 µM -0.9637799254621 0.187864779201217 no 2787 0.167578136605379 4039 45595589 SGTC_2764 methyldopa 94.69 µM -0.965097708654759 0.187539959112095 no 2788 0.167247937259625 4042 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2324 6149169 200 µM -0.967639318437177 0.186914459180393 no 2789 0.166612266771353 3954 2888231 SGTC_737 1950-0117 57.9 µM -0.967757206131791 0.186885477927031 no 2790 0.166582820304435 4014 5393513 SGTC_943 3253-1379 105 µM -0.967769880320986 0.186882362297598 no 2791 0.166579654694 4073 668464 SGTC_1642 st009582 77.7 µM -0.969912262645611 0.186356173682432 no 2792 0.166045113568877 4027 6739311 SGTC_830 4076-0286 57.8 µM -0.970802710665119 0.186137741826458 no 2793 0.165823266255496 4124 6866659 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.971130269987754 0.186057429641811 no 2794 0.165741705950897 4092 5379071 SGTC_1603 st002045 67.8 µM -0.971130473367159 0.186057379783183 no 2795 0.165741655318704 4050 5887985 SGTC_1116 jasmonic acid  1.58368 µM -0.971822608054539 0.185887750377543 no 2796 0.165569403287378 4119 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2991 9074669 71.4286 µM -0.972314729410355 0.185767198896096 no 2797 0.165446999163404 4068 17333109 SGTC_991 3996-0057 64.7 µM -0.972808581510479 0.18564627220947 no 2798 0.165324223420934 4115 715343 SGTC_785 1270-0111 65.3 µM -0.972865024731693 0.185632454397487 no 2799 0.165310194921383 3990 6741994 SGTC_1399 3562-5772 25 µM -0.973099510738044 0.185575056931076 no 2800 0.165251923595693 4015 23847490 SGTC_563 tetrahydrosecaminediol 614 µM -0.973986461302602 0.185358048871174 no 2801 0.16503163075843 4126 334274 A psychoactive constituent of the cannabis plant. SGTC_1326 1431-2094 10.8 µM -0.974215548992204 0.185302024149224 no 2802 0.164974762920841 4049 616278 SGTC_169 k015-0017 16.025 µM -0.976567381572996 0.184727478054785 no 2803 0.164391687044973 4012 1840002 SGTC_2319 6033012 152.6 µM -0.976600513821578 0.184719391858461 no 2804 0.164383482317996 4016 847246 SGTC_1190 1486-1332 13 µM -0.9807246011763 0.183714593504827 no 2805 0.163364284378529 4065 4150046 SGTC_2781 5567276 71.43 µM -0.984623531377026 0.182767790577742 no 2806 0.162404513323425 4120 2853274 SGTC_2859 9028643 45.46 µM -0.985283020669761 0.182607944164995 no 2807 0.162242535290813 3953 17151580 SGTC_3026 9090633 49.47 µM -0.987244754307381 0.182132977253986 no 2808 0.161761333307926 4073 25236842 SGTC_3173 9105693 49.47 µM -0.987521339035313 0.182066073862942 no 2809 0.161693563551132 4093 17096658 SGTC_1233 0325-0408 14.2 µM -0.98778668789865 0.182001902770903 no 2810 0.161628564240304 4123 12874 SGTC_2670 beta-carotene 100 µM -0.987838303537237 0.181989421858724 no 2811 0.161615922558887 3999 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_949 1165-0505 146 µM -0.989072548496505 0.181691134852547 no 2812 0.161313823765647 4094 6244267 SGTC_786 4544-0069 423 µM -0.990980928184752 0.181230528413734 no 2813 0.160847446531159 4082 748821 YLR208W SEC13 SGTC_2518 prenyletin 46.28 µM -0.991248679713235 0.181165962467551 no 2814 0.160782082860646 4032 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2899 9053889 58.44 µM -0.991941605546743 0.180998936349691 no 2815 0.160613005904325 4046 6470052 SGTC_1809 st050081 57.6 µM -0.993423452149957 0.180642068982401 no 2816 0.160251818677477 4176 5036894 SGTC_2783 7738165 71.43 µM -0.99491582514052 0.18028311284734 no 2817 0.159888602722846 4081 17201110 SGTC_1647 st011722 22.4 µM -0.996636596882925 0.17986977666319 no 2818 0.159470467662518 4063 2854783 SGTC_361 000s-0510 1.45 µM -0.99716359800084 0.179743308061147 no 2819 0.159342553525485 4044 660 SGTC_2062 5245942 200 µM -0.998560149308693 0.17940843692499 no 2820 0.15900390646957 4145 1376160 SGTC_3108 9121785 49.47 µM -0.99936209386919 0.179216320577758 no 2821 0.158809657771977 3941 17140271 SGTC_3316 9136639 10.545 µM -0.999997940927458 0.179064087070273 no 2822 0.158655752167245 4096 4903665 SGTC_1664 st014217 9.02 µM -1.00048424822572 0.178947711061573 no 2823 0.158538108408056 4134 3982782 SGTC_1406 3909-7906 11.9 µM -1.00231691228968 0.178509572278863 no 2824 0.158095278444909 4101 X1406 SGTC_3266 9136860 49.47 µM -1.0034335774377 0.178242940411266 no 2825 0.157825855059729 3936 4871271 YPR165W RHO1 SGTC_1125 tnp00248 1.32998 µM -1.00397381894224 0.178114034310937 no 2826 0.157695616586397 4195 24207736 SGTC_3075 9116269 49.47 µM -1.00565461480697 0.177713358458846 no 2827 0.15729087113601 4132 17015205 YNL244C SUI1 SGTC_1733 st037357 54.9 µM -1.00605625985555 0.177617696711038 no 2828 0.157194253854648 4005 1272339 YGL099W LSG1 SGTC_1340 1486-1359 257 µM -1.00703994702994 0.177383544451444 no 2829 0.156957788936484 4018 4309068 SGTC_1292 0kpi-0043 232 µM -1.00746117901952 0.177283335996544 no 2830 0.156856602133346 4114 3333905 SGTC_2773 thioridazine 9.09 µM -1.00765265728396 0.177237796336243 no 2831 0.156810620120462 4122 5452 An antipsychotic. SGTC_730 1436-0052 41.2 µM -1.00952810269599 0.176792146004923 no 2832 0.156360715477719 4128 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_714 4296-0578 26.1 µM -1.01163473516174 0.176292405629652 no 2833 0.155856365699222 4130 1589775 SGTC_143 4032-1194 15.74 µM -1.01177334548084 0.17625955553176 no 2834 0.155823218591303 4114 1806963 SGTC_2030 5175110 200 µM -1.01238195613245 0.176115363061675 no 2835 0.155677731171552 4130 2831986 SGTC_2155 5570423 76 µM -1.01274597190984 0.176029155880862 no 2836 0.155590756600647 4049 797402 SGTC_1020 4335-0961 93.3 µM -1.0162531468118 0.175199946584401 no 2837 0.154754426890939 4042 669075 SGTC_2325 6158266 200 µM -1.01806906917406 0.174771578981761 no 2838 0.154322566693889 4133 3623240 SGTC_591 4299-0174 154 µM -1.01849459272869 0.174671296193329 no 2839 0.154221484617185 4114 5509088 SGTC_3087 9117406 49.47 µM -1.01972411567617 0.17438174086253 no 2840 0.153929660565809 4136 42546093 SGTC_916 4466-0038 42 nM -1.02067513634957 0.174157982700674 no 2841 0.153704189096105 4184 5722064 YGL116W CDC20 SGTC_444 curcumin 90.4 µM -1.02305403703233 0.173599069467946 no 2842 0.153141148561871 4056 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1440 4100-1550 40 µM -1.02382458877998 0.173418276397392 no 2843 0.152959067083912 4115 742806 SGTC_614 0462-0418 107 µM -1.02438641697267 0.173286531311828 no 2844 0.152826397524215 3896 5188303 SGTC_2166 5933061 31.504 µM -1.02530190411745 0.173071992048143 no 2845 0.152610378816416 4242 2877375 SGTC_210 3551-0445 56.827 µM -1.02531180180855 0.173069673504788 no 2846 0.152608044460759 4167 2865180 YOR207C RET1 SGTC_2553 4-methylesculetin 85.09 µM -1.02665079348902 0.172756195856866 no 2847 0.152292463647828 4143 5319502 SGTC_1402 3909-7673 35.9 µM -1.02753950723096 0.172548334848983 no 2848 0.152083246137879 4120 5328014 SGTC_2470 5664817 21.68 µM -1.0281511303352 0.172405375180148 no 2849 0.151939371159315 4140 2859561 SGTC_381 3461-2219 42.7 µM -1.0284861494354 0.172327100462236 no 2850 0.151860601380932 4120 2883159 SGTC_2364 9055074 200 µM -1.03007429586876 0.171956350422 no 2851 0.151487565192573 4143 6470630 SGTC_1053 3366-3204 134 µM -1.03200294509392 0.171506795878608 no 2852 0.151035368922398 4161 3632071 YPR165W RHO1 SGTC_877 0771-0151 33.1 µM -1.03518964041423 0.170765646990292 no 2853 0.150290177925968 4144 6166523 SGTC_742 0kpi-0133 140 µM -1.03649156753445 0.170463440655681 no 2854 0.149986435688253 4166 2728852 SGTC_870 0573-2213 57.6 µM -1.03990408768121 0.16967294512274 no 2855 0.149192231586565 4123 3916321 SGTC_2079 5212404 121 µM -1.04016568241687 0.169612445019289 no 2856 0.149131466117678 4100 758462 SGTC_3306 9127676 59.7925 µM -1.04182736329673 0.169228464367509 no 2857 0.148745862654723 4133 41905287 SGTC_1990 st072050 59.8 µM -1.0443878968452 0.168637870621003 no 2858 0.148152980495221 4125 17233948 SGTC_2000 st075254 36.4 µM -1.04616124761669 0.168229620094996 no 2859 0.147743295671921 4053 17234175 SGTC_3336 9143619 71.43 µM -1.04750324747693 0.167921095658973 no 2860 0.147433767593427 4182 45595730 SGTC_1704 st028805 70.8 µM -1.04970288271985 0.167416189970697 no 2861 0.146927368986581 4174 2876101 SGTC_3262 9137218 49.47 µM -1.05136934738191 0.167034320591479 no 2862 0.146544494162031 4027 17650664 SGTC_1312 1218-2183 165 µM -1.0520941954754 0.16686839751317 no 2863 0.146378167497001 4189 6744073 SGTC_1724 st037281 8.293 µM -1.05213574095586 0.166858890668723 no 2864 0.146368638139893 4112 574124 YDL195W SEC31 SGTC_2461 5755302 26.15 µM -1.05440068060861 0.166341133732895 no 2865 0.145849755400264 4197 2788904 SGTC_126 0417-1624 672.48 µM -1.05531745694501 0.166131857278437 no 2866 0.145640079883429 4211 41912 YDL195W SEC31 SGTC_1545 lovastatin 49.4 µM -1.05542216101719 0.166107966859326 no 2867 0.145616145961963 4197 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3131 9127911 49.47 µM -1.05700518859909 0.165747036559962 no 2868 0.1452546097171 4207 45595681 SGTC_1094 duloxetine 25.4 µM -1.05852375528213 0.165401280200861 no 2869 0.144908363256123 4159 60834 A selective serotonin reuptake inhibitor. SGTC_13 0199-0087 65 µM -1.05873730321799 0.165352695778723 no 2870 0.144859717065704 4215 4589825 SGTC_135 0933-0004 26.348 µM -1.06005451886078 0.16505321940277 no 2871 0.144559898637024 4131 21230617 YGL099W LSG1 SGTC_659 k018-0002 107 µM -1.06101926768914 0.164834101260769 no 2872 0.144340572461748 4156 6797879 YHR007C ERG11 SGTC_3 0833-0587 95.581 µM -1.06522080317784 0.163882027588397 no 2873 0.143388010851374 4054 5382644 SGTC_257 daunorubicin 18.5 µM -1.06695081496197 0.163491043847588 no 2874 0.142997023383978 4174 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2318 6029776 164 µM -1.06751145675569 0.163364468530271 no 2875 0.142870471483099 4215 818325 SGTC_826 1683-5028 118 µM -1.06843312369904 0.16315652345159 no 2876 0.142662591067176 4217 722377 SGTC_413 propylparaben 100 µM -1.06914204322167 0.162996695210355 no 2877 0.142502834686787 4111 7175 A pharmaceutical preservative. SGTC_2013 4024628 200 µM -1.07229761717024 0.162286495986427 no 2878 0.141793188352126 4213 5230760 SGTC_1619 st003326 88.7 µM -1.07315606624323 0.162093640951168 no 2879 0.141600549463946 4169 2849032 SGTC_2953 9074162 66.49 µM -1.07401709077596 0.161900357314114 no 2880 0.141407510819711 4172 16451992 SGTC_1097 itavastatin 7.23 µM -1.07486081113318 0.161711103853899 no 2881 0.141218524798384 4188 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2710 st078562 53.7235 µM -1.07491934726638 0.161697979065451 no 2882 0.141205419568861 4107 17250908 SGTC_35 0133-0054 64.071 µM -1.07569613710159 0.161523875421282 no 2883 0.141031587809376 4185 99677 SGTC_1931 st074438 57.1 µM -1.07605491931423 0.161443502038954 no 2884 0.140951347745004 4142 2787313 SGTC_2750 bromebric acid 70.15 µM -1.07634125871065 0.161379375808004 no 2885 0.140887331421091 4209 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3246 9135460 32.98 µM -1.07696675984621 0.161239351472593 no 2886 0.140747558000543 4138 41446951 SGTC_3297 9117502 71.43 µM -1.0778597104904 0.161039593416341 no 2887 0.14054818386411 4176 7453720 SGTC_1303 1160-0052 261 µM -1.07833162360609 0.160934089070734 no 2888 0.140442894624459 4112 3562476 SGTC_2439 5492030 7.2 µM -1.07957111459314 0.160657194333877 no 2889 0.140166605041617 4170 5722370 SGTC_104 0074-0074 590.992 µM -1.08681341117794 0.159045533519114 no 2890 0.13855963977889 3951 3943124 SGTC_2463 5473429 200 µM -1.08703264873809 0.158996911355605 no 2891 0.138511190545181 4156 5399405 SGTC_868 0527-0199 213 µM -1.08810221822574 0.158759843584721 no 2892 0.138274992290915 4140 2849450 SGTC_2650 prasterone 100 µM -1.08877207282478 0.158611489821757 no 2893 0.138127204938458 4158 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1854 st056233 32.9 µM -1.09234135550007 0.157822528288313 no 2894 0.137341544633378 4117 5393174 SGTC_2497 7-hydroxyflavone 100 µM -1.09326814412339 0.157618091263545 no 2895 0.137138042623702 4210 5281894 SGTC_1933 st074711 15.9 µM -1.09368981666558 0.15752513362438 no 2896 0.13704552100116 4174 17250958 SGTC_1899 st063254 59.6 µM -1.09556721937864 0.157111697874386 no 2897 0.136634106895053 4134 3093813 SGTC_426 0988-0037 14.6 µM -1.09576258300704 0.157068716538638 no 2898 0.136591343466583 4232 5383008 SGTC_430 0958-0115 16.4 µM -1.09784345409245 0.156611390579518 no 2899 0.136136426482946 4144 6833180 SGTC_1773 st048542 73.5835 µM -1.09907119363793 0.156341974218431 no 2900 0.135868506805843 4136 3237138 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.10003770711273 0.156130096437319 no 2901 0.135657846540146 4185 688662 SGTC_969 1313-0238 134 µM -1.10131416725716 0.155850562644544 no 2902 0.13537997366222 4224 5212874 SGTC_1374 2889-5571 141 µM -1.10324369811384 0.155428638722479 no 2903 0.134960674670148 4240 2853281 SGTC_2294 7971431 200 µM -1.10605429944358 0.154815403845403 no 2904 0.134351508815583 4195 5741572 SGTC_138 0850-0259 40.9225 µM -1.10720289432815 0.154565256792003 no 2905 0.134103108234783 4146 6813004 SGTC_772 k072-0172 35.3 µM -1.10721909330501 0.154561730804759 no 2906 0.134099607224925 4245 5861980 SGTC_849 0386-0493 241 µM -1.10818876110111 0.154350762690197 no 2907 0.133890151785915 4169 726119 SGTC_548 1436-0017 110 µM -1.10924556039223 0.154121054535097 no 2908 0.133662131479406 4263 9677137 SGTC_1822 st052468 42 µM -1.11170935254209 0.153586398003547 no 2909 0.133131568641469 4194 2873678 SGTC_751 0833-0568 350 µM -1.11225375259868 0.153468426051157 no 2910 0.133014531145971 4229 6954252 SGTC_1873 rapamycin 2 nM -1.11512759073665 0.152846657804913 no 2911 0.132397874833276 4164 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1905 st060207 84.5 µM -1.11525346601801 0.152819462342312 no 2912 0.132370910146955 4185 1948547 SGTC_2302 7771753 200 µM -1.11684216505629 0.152476498396572 no 2913 0.132030908359535 4225 2203047 SGTC_2272 7805186 180 µM -1.11735533216016 0.152365826528005 no 2914 0.131921212876248 4219 2956062 YPR165W RHO1 SGTC_3265 9137266 49.47 µM -1.12185105808432 0.151398538626821 no 2915 0.130962886454153 4156 17224265 SGTC_3292 9120825 59.784 µM -1.12224724582015 0.151313492195668 no 2916 0.130878664763389 4229 24824900 SGTC_2980 9014342 25.29 µM -1.12606068378291 0.150496517190299 no 2917 0.130069917087601 4283 2996599 SGTC_2504 purpurogallin 52.29 µM -1.12696780772058 0.150302612175857 no 2918 0.129878046064892 4115 5281571 An antioxidant. SGTC_672 1441-0018 53.7 µM -1.12721616104246 0.150249553705155 no 2919 0.129825549606184 4214 251141 SGTC_1987 st072290 61.9 µM -1.12786560025581 0.150110865820986 no 2920 0.129688341815839 4228 54697379 SGTC_3188 9110789 49.47 µM -1.13239083178423 0.149146871198442 no 2921 0.128735078819551 4213 849217 SGTC_284 0988-0104 32.6 µM -1.13604049875666 0.148372413585773 no 2922 0.127969807650715 4216 4666532 SGTC_529 4076-0302 30.3 µM -1.13813788997656 0.147928567337329 no 2923 0.127531454363211 4188 5816522 SGTC_523 1934-0222 13.7 µM -1.1385712083412 0.147836980163264 no 2924 0.127441021417893 4175 1361595 SGTC_2909 7941780 10.49 µM -1.13873373055577 0.147802638883527 no 2925 0.12740711475836 4210 1243215 SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.13940184809451 0.147661520383834 no 2926 0.12726779274841 4231 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_445 e6 berbamine 66 µM -1.14130782955097 0.14725943871523 no 2927 0.126870922543211 4257 6610268 A calcium/calmodulin antagonist. SGTC_2157 5649910 96.377 µM -1.14209582572785 0.147093419389704 no 2928 0.126707095184725 4222 2858091 SGTC_3001 9076041 71.4286 µM -1.14467333710683 0.146551252129838 no 2929 0.126172250159758 4210 16004211 SGTC_534 k292-0788 63.4 µM -1.14494435208334 0.146494323446766 no 2930 0.126116104919702 4291 4146317 SGTC_2443 5493264 126.67 µM -1.1450519004403 0.146471736240511 no 2931 0.12609382932456 4275 5340055 SGTC_483 fpl-64176 144 µM -1.14551328341097 0.146374863544929 no 2932 0.125998298038269 4343 3423 SGTC_744 1594-0068 283 µM -1.14627369812668 0.146215299563152 no 2933 0.125840961118584 4210 668392 SGTC_1633 st005664 67.9 µM -1.14750304436622 0.145957583059196 no 2934 0.125586887817305 4235 2063822 SGTC_489 paxilline 115 µM -1.14800765504697 0.145851886380124 no 2935 0.125482701844577 4231 105008 A toxic potassium channel blocker. SGTC_979 1426-2828 121 µM -1.14862617996037 0.145722399204312 no 2936 0.125355078529821 4335 747872 SGTC_2589 lobaric acid 100 µM -1.14902429370464 0.145639095635628 no 2937 0.125272981691092 4221 73157 A novel microtubule depolymerizer. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.15042301981429 0.145346672179612 no 2938 0.124984841703731 4235 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2765 myclobutanil 7.74 µM -1.15108035279522 0.145209383953464 no 2939 0.124849590007208 4274 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_132 0417-1715 25.805 µM -1.15291414775022 0.144826845458002 no 2940 0.124472812244497 4237 6769098 SGTC_2376 9072922 81.32 µM -1.15655846553392 0.144068639077131 no 2941 0.123726399932685 4254 17087968 SGTC_1806 st050005 60.3 µM -1.15697059908552 0.143983062785958 no 2942 0.123642186298968 4292 5194765 SGTC_46 0329-0187a 2.197 µM -1.15776916974154 0.143817343460218 no 2943 0.123479123988459 4292 46494817 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.15802440406914 0.143764404398582 no 2944 0.123427038778104 4232 641818 YHR062C RPP1 SGTC_2996 9066192 71.4286 µM -1.16224606227156 0.142890682480052 no 2945 0.122567764549378 4285 6472854 SGTC_2275 7947463 200 µM -1.16285859843643 0.142764209659821 no 2946 0.12244343875461 4212 1225414 SGTC_2271 7849410 118.62 µM -1.16428481873378 0.142470025481872 no 2947 0.12215430337744 4196 972430 SGTC_700 3453-2283 142 µM -1.16965847372159 0.14136529490145 no 2948 0.121069217863635 4316 565664 SGTC_648 0375-0473 33.3 µM -1.17093078423278 0.141104582219233 no 2949 0.120813299997115 4223 1713139 SGTC_125 0133-0007 11.75 µM -1.17288667990205 0.140704430440402 no 2950 0.120420625899958 4340 26541 SGTC_1252 0493-0875 34.8 µM -1.17305077403697 0.140670893882603 no 2951 0.120387722568705 4236 3960963 SGTC_1284 0929-0043 16 µM -1.17502976367128 0.140266867275993 no 2952 0.11999140415632 4270 1239883 SGTC_3139 9095020 49.47 µM -1.17807407037009 0.13964688770865 no 2953 0.119383539120014 4082 25236292 SGTC_2519 cryptotanshinone 88.04 µM -1.1791197060565 0.139434372326466 no 2954 0.119175256384118 4241 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2561 acetosyringone 100 µM -1.18195362363101 0.138859512397411 no 2955 0.11861205147272 4246 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_3114 9122766 49.47 µM -1.18242060840943 0.138764939684345 no 2956 0.118519425003592 4275 17176985 SGTC_748 act1.228 77.9 µM -1.18541454739464 0.138159656164222 no 2957 0.117926791371528 4222 4421505 YNR035C ARC35 SGTC_1305 1181-0477 144 µM -1.18571892113181 0.13809822200645 no 2958 0.11786665988705 4329 6252086 SGTC_3117 9124945 49.47 µM -1.18907335970019 0.137422403070878 no 2959 0.117205400251042 4172 17592065 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.19079579634353 0.137076262566516 no 2960 0.116866879772432 4272 229346 A bile salt which induces apoptosis. SGTC_1318 1280-3875 124 µM -1.19393297038707 0.136447348350053 no 2961 0.116252094586319 4278 373245 SGTC_2638 epoxomicin 18 µM -1.20067914130468 0.135101626899934 no 2962 0.114937844185512 4257 9915668 A protesome inhibitor. SGTC_3195 9113082 49.47 µM -1.2010814906097 0.135021655137849 no 2963 0.114859796083237 4284 17018038 SGTC_1813 st051246 8.6015 µM -1.20168663571466 0.134901436418964 no 2964 0.114742480462944 4226 5291959 SGTC_2701 st077767 14.721 µM -1.2022657630034 0.13478645520389 no 2965 0.114630288610184 4258 5721188 SGTC_3214 9129694 49.47 µM -1.20388150448488 0.134466017889885 no 2966 0.114317690715439 4319 17158655 SGTC_635 k038-0028 24.7 µM -1.20532148145648 0.134180879662165 no 2967 0.114039609968583 4288 4035102 SGTC_2147 5545932 89.7195 µM -1.20712811293555 0.133823725839529 no 2968 0.113691404850111 4329 797404 SGTC_2986 9022445 71.43 µM -1.20740055045005 0.133769924290382 no 2969 0.11363896183424 4295 6459286 SGTC_2035 5154463 94.595 µM -1.21111781777287 0.133037315693973 no 2970 0.112925126770509 4308 2769623 SGTC_291 SEC14.278 35.5 µM -1.21178154047397 0.132906798660416 no 2971 0.112798008139069 4325 1068044 SGTC_3096 9117468 49.47 µM -1.21315305312277 0.132637378419143 no 2972 0.112535654709203 4207 41316311 SGTC_2269 7935389 174.42 µM -1.21672799428008 0.13193688544173 no 2973 0.111853862128483 4269 97605 SGTC_891 0929-0073 133 µM -1.21988717028292 0.1313199870604 no 2974 0.111253825020681 4335 5603632 SGTC_2181 6316240 54.2555 µM -1.22517236673949 0.130292395762535 no 2975 0.110255141836822 4307 12779990 SGTC_41 0478-0632 82.643 µM -1.2277929322156 0.129784952265713 no 2976 0.109762354768625 4277 3750424 SGTC_1889 st059080 5.18 µM -1.22981752376028 0.129393850764292 no 2977 0.109382722275049 4271 176925 Isolated from Daphnopsis sellowiana. SGTC_458 nppb 133 µM -1.23171946295615 0.1290271873772 no 2978 0.109026948424994 4365 4549 A chloride channel blocker. SGTC_1407 3909-7909 12.3 µM -1.23500635670152 0.128395226713213 no 2979 0.108414069186833 4330 4411780 SGTC_1149 3909-7961 23.3 µM -1.24124571841601 0.127201522900112 no 2980 0.107257495198583 4376 735261 SGTC_2023 5144124 124 µM -1.24277754111849 0.126909641575327 no 2981 0.106974910396541 4304 2830192 SGTC_578 3460-0051 92 µM -1.24306704363973 0.126854530710439 no 2982 0.106921564473156 4369 2876744 SGTC_2761 levamisole 97.89 µM -1.24372137188229 0.126730031543479 no 2983 0.106801063717481 4330 26879 An alkaline phosphatase inhibitor. SGTC_2828 7998861 71.43 µM -1.24722154155029 0.126065498527901 no 2984 0.106158138190538 4308 2988188 SGTC_1296 1068-0102 11.9 µM -1.25196094338861 0.125169565737012 no 2985 0.105292047983821 4315 767053 SGTC_2380 9035439 200 µM -1.25213227729282 0.125137260397446 no 2986 0.105260834024183 4409 6462575 SGTC_1159 4092-0538 61.2 µM -1.25501755734482 0.124594109770623 no 2987 0.104736193205098 4354 717301 SGTC_2185 6113692 200 µM -1.25670887020118 0.124276489319045 no 2988 0.10442953748845 4327 874150 SGTC_1503 4585-0012 61.3 µM -1.2575648633378 0.124115953935841 no 2989 0.104274583644475 4361 2922052 SGTC_2226 7298446 200 µM -1.25868541015505 0.123906022761631 no 2990 0.104071991636797 4345 3283010 SGTC_409 arachidonic acid 100 µM -1.25980417567533 0.123696673365298 no 2991 0.103870006540198 4316 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2149 5554786 194.827 µM -1.26039076024845 0.123587007540516 no 2992 0.103764216590847 4366 745063 YPR165W RHO1 SGTC_3305 9127027 53.8275 µM -1.26103253338845 0.123467101871697 no 2993 0.103648563001386 4279 41905295 SGTC_1101 ebselen 5.29 µM -1.26374605168216 0.122961022504165 no 2994 0.103160595103248 4352 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_173 1273-0061 2.693 µM -1.26422486790954 0.122871873001674 no 2995 0.103074663753728 4304 2847414 YPL266W DIM1 SGTC_1280 0880-0253 10.1 µM -1.26740864501515 0.122280246709512 no 2996 0.102504605114885 4316 6836607 SGTC_3269 9137823 49.47 µM -1.27210172333579 0.121411805121229 no 2997 0.101668489482899 4266 17682936 SGTC_477 mead ethanolamide 10 µM -1.27590384796589 0.12071141873576 no 2998 0.100994755333619 4297 16061185 SGTC_117 lucigenin 22.078 µM -1.27941921880207 0.120066389946088 no 2999 0.10037473480063 4342 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2154 5570129 200 µM -1.28087287272027 0.119800372915149 no 3000 0.10011916126394 4396 673366 SGTC_3180 9109287 49.47 µM -1.28309341007532 0.119394819805449 no 3001 0.0997296761255455 4395 18891271 SGTC_2315 7733312 200 µM -1.28402440315773 0.119225074221264 no 3002 0.0995667084936468 4259 726316 SGTC_1760 st045453 10.4495 µM -1.28498806527438 0.119049551658953 no 3003 0.0993982273071301 4391 3323419 YIL048W NEO1 SGTC_296 1222-0039 74.9 µM -1.28593726477816 0.118876841771185 no 3004 0.0992324785117266 4364 5984176 SGTC_1723 st034307 2.5525 µM -1.2859929983426 0.118866706373901 no 3005 0.0992227526269429 4360 867466 SGTC_2976 9009005 19.48 µM -1.28802931083073 0.118496812310235 no 3006 0.0988678801264286 4370 2993148 SGTC_981 1488-1094 54.9 µM -1.29005228369304 0.11813014764328 no 3007 0.0985162527892394 4334 3449522 SGTC_2205 7238770 200 µM -1.29030053907267 0.118085206588968 no 3008 0.0984731649047557 4421 279867 SGTC_2550 chrysin dimethyl ether 71.87 µM -1.29090619369972 0.117975617177698 no 3009 0.0983681037240822 4191 88881 An O-methylated flavonoid and antioxidant. SGTC_185 k048-0037 25.491 µM -1.29475990622582 0.117279997252426 no 3010 0.0977015335044397 4397 6827589 SGTC_1793 st048256 72.231 µM -1.29661298781767 0.116946540432466 no 3011 0.0973821907034576 4321 672022 SGTC_3103 9120822 49.47 µM -1.29668042597263 0.116934417810693 no 3012 0.0973705834978215 4365 17141819 SGTC_2235 salicylic acid 500 µM -1.29735148518503 0.116813837335358 no 3013 0.0972551385628055 4392 338 A COX inhibitor and kinase inhibitor. SGTC_1415 3966-0071 78.1 µM -1.29783614262752 0.116726805630697 no 3014 0.097171823533413 4278 2893185 SGTC_9 0092-0002 10.449 µM -1.2990629293865 0.116506712549038 no 3015 0.0969611668848452 4367 759368 SGTC_593 1203-0218 61.7 µM -1.30246813634908 0.115897340380869 no 3016 0.0963782017893358 4398 3666956 SGTC_1230 0170-0365 3.77 µM -1.30529950313202 0.115392384539907 no 3017 0.0958954415994047 4400 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2560 caryophyllene 100 µM -1.30531758196627 0.115389165328991 no 3018 0.0958923648054007 4405 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_3129 9127257 49.47 µM -1.30980036621516 0.114592906594043 no 3019 0.0951316896189017 4313 837894 SGTC_1475 4092-1048 11.7 µM -1.31098390972877 0.114383332642792 no 3020 0.0949315998868505 4377 2881759 SGTC_2860 9025725 38.96 µM -1.31173713891546 0.114250098044709 no 3021 0.094804420597547 4417 40546248 SGTC_1699 st031318 29.054 µM -1.3117816276226 0.114242232138213 no 3022 0.0947969128123236 4430 5340658 SGTC_49 0717-0965 32.132 µM -1.31378692189329 0.113888082830253 no 3023 0.0944589599553421 4442 5889349 YGL099W LSG1 SGTC_1703 st026983 48.3 µM -1.31423474365697 0.113809101280167 no 3024 0.0943836099087909 4398 1104023 SGTC_3080 9117754 49.47 µM -1.32142257993709 0.112546733560706 no 3025 0.0931802506194545 4375 9550191 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.32662161787081 0.111639904366087 no 3026 0.0923169405402215 4340 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_846 0335-0850 148 µM -1.3269549599359 0.111581940850845 no 3027 0.0922617910736262 4374 6819598 SGTC_485 niflumic acid 177 µM -1.33257995735069 0.11060707843298 no 3028 0.0913348430448472 4422 4488 A COX2 inhibitor. SGTC_3010 9080089 71.4286 µM -1.33301578981249 0.110531800381936 no 3029 0.0912633110882967 4397 17027233 SGTC_2549 cedrol 20.94 µM -1.3389391810243 0.109512337449533 no 3030 0.0902952365399147 4334 6708665 A sedative which affects the nervous system. SGTC_1831 st055328 12 µM -1.34065994953889 0.109217449156402 no 3031 0.090015441759278 4379 1103068 SGTC_2888 9058547 12.99 µM -1.34226983861751 0.108942079259376 no 3032 0.0897542596025337 4319 16476514 SGTC_2894 9048625 32.47 µM -1.34233089880908 0.108931644808214 no 3033 0.0897443645345294 4419 4092861 SGTC_452 diindolylmethane 8 µM -1.34252363377851 0.108898713436744 no 3034 0.0897131363194638 4395 3071 Inhibits expression of several cancer promoting factors. SGTC_3039 9090270 49.47 µM -1.34466164861972 0.10853388471892 no 3035 0.0893672624876506 4407 17173750 SGTC_227 fluconazole 33.516 µM -1.34590592482112 0.108321967847738 no 3036 0.0891664289164436 4396 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_235 0330-0087 5 mM -1.34848689729109 0.10788334351577 no 3037 0.0887509158167876 4454 46494818 YHR062C RPP1 SGTC_2435 5706476 10.6 µM -1.3509176270346 0.10747142321697 no 3038 0.0883609105014657 4393 5725375 SGTC_2608 thymoquinone 42.66 µM -1.35091992219377 0.107471034807366 no 3039 0.088360542852651 4363 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1769 st044406 64.4 µM -1.35114331329102 0.107433235191053 no 3040 0.0883247645267927 4378 670903 SGTC_2749 bexarotene 57.39 µM -1.35152902920646 0.107367991435238 no 3041 0.0882630136684191 4421 82146 An retinoic acid receptor inhibitor. SGTC_123 0083-0120 66.675 µM -1.35181409551978 0.107319790893939 no 3042 0.0882173969037657 4389 16001701 SGTC_1954 st077032 68.9 µM -1.35394401702781 0.106960145989694 no 3043 0.0878771195060415 4347 698907 SGTC_942 3253-1115 227 µM -1.35532313076342 0.106727741879913 no 3044 0.0876573142785852 4426 46497897 SGTC_307 1501-1223 22.3 µM -1.35609167403458 0.106598387508961 no 3045 0.0875350008209728 4430 2830329 SGTC_982 1491-0518 27.5 µM -1.35803148854999 0.106272398557968 no 3046 0.0872268463556929 4345 3091256 SGTC_2756 carbadox 75.1 µM -1.36032056233451 0.105888642907295 no 3047 0.0868642520944335 4345 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_564 3555-0129 330 µM -1.36524183467009 0.105067001234589 no 3048 0.0860885268313046 4306 563260 SGTC_899 1083-0020 478 µM -1.36796217479643 0.10461480619032 no 3049 0.08566195813981 4461 767123 SGTC_3264 9137442 49.47 µM -1.37001543122966 0.104274433499427 no 3050 0.0853410423457976 4391 17015726 SGTC_435 c-PAF 6.7 µM -1.37388186106556 0.103635667396765 no 3051 0.0847391808714864 4365 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_3116 9124943 49.47 µM -1.37412966967032 0.103594824403004 no 3052 0.0847007149674053 4379 41905195 YPL160W CDC60 SGTC_2919 7978188 46.38 µM -1.37434449769055 0.103559426613034 no 3053 0.084667379047564 4433 2980291 SGTC_2207 7258803 200 µM -1.37615631954471 0.103261236994348 no 3054 0.0843866210968417 4432 3666799 SGTC_2564 betulinic acid 100 µM -1.37940051801996 0.102728865276121 no 3055 0.0838856498185362 4450 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_585 0kpi-0023 191 µM -1.37944976489354 0.102720799281696 no 3056 0.0838780623311685 4353 64601 SGTC_1144 3486-0183 12.5 µM -1.38150196411007 0.102385084984558 no 3057 0.083562337165849 4435 6744069 SGTC_2231 micatex 6.853 µM -1.3853943499764 0.101750532170261 no 3058 0.0829659588499146 4451 20737 An antifungal of unknown mechanism. SGTC_2596 sinensetin 100 µM -1.38680950578915 0.101520538775015 no 3059 0.0827499288718329 4433 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2208 7283366 200 µM -1.3889240785354 0.101177580925578 no 3060 0.0824279188776816 4424 898663 SGTC_1316 1272-0050 65.9 µM -1.38948683234804 0.10108645154639 no 3061 0.0823423811245884 4404 7340392 SGTC_1513 0337-0559 19 µM -1.38995772859913 0.101010243080185 no 3062 0.0822708569668557 4415 775073 SGTC_1345 1488-0192 31.4 µM -1.39048313605637 0.100925262123135 no 3063 0.0821911083719389 4479 658348 SGTC_2874 9043904 71.43 µM -1.39051834913614 0.100919568519719 no 3064 0.0821857656625148 4362 4463428 SGTC_266 formosanin C 406 nM -1.39292750580704 0.100530587824243 no 3065 0.0818208568928927 4281 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_60 0986-0278 202 µM -1.39395260535098 0.10036540813437 no 3066 0.0816659585705651 4379 3110598 SGTC_1111 tnp00062 510.699 nM -1.3958544900356 0.100059472216776 no 3067 0.0813791588115619 4460 676306 SGTC_2533 agelasine 13.65 µM -1.39772188153212 0.0997597479056993 no 3068 0.0810983003627876 4486 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_654 1124-0271 80.9 µM -1.39997275260053 0.0993993458948257 no 3069 0.0807607389956512 4421 5403748 SGTC_100 0086-0128 49.5915 µM -1.40076972878681 0.0992719651474297 no 3070 0.0806414717799895 4439 93297 SGTC_551 k048-0028 34.9 µM -1.40183792675313 0.0991014222580553 no 3071 0.0804818250130841 4398 6836383 SGTC_1764 st044502 93.5 µM -1.40299093384112 0.0989175797733064 no 3072 0.0803097712384997 4461 8407 SGTC_2316 5844804 197.44 µM -1.40458054926804 0.0986645310965789 no 3073 0.0800730219419009 4443 776813 SGTC_2360 9040895 200 µM -1.40542769046167 0.098529869556929 no 3074 0.0799470687195593 4457 4914414 SGTC_1381 2324-0066 62.1 µM -1.40716409081979 0.0982542720618821 no 3075 0.0796893684887603 4463 10885928 SGTC_1713 st033146 12.748 µM -1.40835299140412 0.0980658984056456 no 3076 0.0795132857924768 4428 674619 SGTC_1069 diphenylcyclopropenone 8.49 µM -1.41140100908533 0.0975841686899325 no 3077 0.0790632028020393 4481 65057 A dermal irritant. YDR527W RBA50 SGTC_2861 9024595 19.48 µM -1.41254415052832 0.0974039469230941 no 3078 0.0788949001866494 4375 16482810 SGTC_215 1287-0124 461.5 µM -1.41548677945572 0.0969411506702113 no 3079 0.0784629109755847 4461 5560863 SGTC_2091 4-phenylthiadiazole 200 µM -1.41686179114368 0.0967254526151937 no 3080 0.0782616697625846 4459 270010 SGTC_2619 obliquin 87.91 µM -1.41973640358784 0.0962756513388739 no 3081 0.0778422178905271 4414 6708593 A bioactive alkalod. YER133W GLC7 SGTC_92 0063-0024 660.874 µM -1.4197765560418 0.0962693794410563 no 3082 0.0778363711122119 4545 3594437 SGTC_3251 9135047 49.47 µM -1.4217685386148 0.0959586044705762 no 3083 0.077546727857604 4495 17682963 SGTC_1059 3448-6867 171 µM -1.42411370584564 0.0955936744941201 no 3084 0.0772067797520995 4423 3934407 SGTC_1739 st037196 92.5 µM -1.42897685102552 0.0948401801957048 no 3085 0.0765054435083896 4470 612214 SGTC_32 0928-0142 34.1 µM -1.43238307874205 0.0943150323953304 no 3086 0.0760171092591442 4453 2244242 SGTC_1851 st056236 18.9 µM -1.43378319354336 0.0940997957688669 no 3087 0.0758170712431423 4440 5393171 SGTC_3242 9133940 49.47 µM -1.43446944792506 0.0939944318031891 no 3088 0.0757191708354986 4454 17248444 SGTC_1563 conessine 56.1 µM -1.44508863058729 0.0923750981002409 no 3089 0.0742164960386603 4531 441082 An anti-amoebic, histamine inhibitor. SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.44996676098222 0.0916381834809024 no 3090 0.0735338942564106 4569 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2057 5236571 38.335 µM -1.45237317681612 0.0912762667638307 no 3091 0.0731989351989034 4411 54684039 YBR257W POP4 SGTC_739 1486-1183 203 µM -1.45250312079198 0.0912567538351172 no 3092 0.0731808810307252 4461 4346692 SGTC_1693 xanthone 101.9 µM -1.45291708589932 0.0911946117316081 no 3093 0.0731233882239136 4503 7020 An insecticide. SGTC_2816 7982706 58.44 µM -1.45335158892998 0.0911294203494505 no 3094 0.0730630802281923 4462 2981853 SGTC_784 4579-0127 173 µM -1.45437700116913 0.090975707961016 no 3095 0.0729209063480377 4501 1948547 SGTC_2520 obtusaquinone 4.71 µM -1.45465100902364 0.0909346659395728 no 3096 0.0728829509115754 4498 5967872 SGTC_2025 5147754 141 µM -1.4555932947078 0.0907936313596094 no 3097 0.0727525413760057 4436 315777 YLR208W SEC13 SGTC_798 1287-0182 476 µM -1.45681187300133 0.0906114840425015 no 3098 0.0725841587915825 4504 1649755 SGTC_1519 esterone 74 µM -1.45963174102039 0.090191023830284 no 3099 0.0721956554457864 4448 698 A steroid. SGTC_827 3253-0474 693 µM -1.46106953449995 0.0899771983775753 no 3100 0.0719981799542255 4466 5402065 SGTC_1055 3448-0672 86 µM -1.46428184642867 0.0895008318824075 no 3101 0.0715584775900964 4443 748378 SGTC_513 4245-1575 41.7 µM -1.46550026230249 0.0893206396391993 no 3102 0.0713922404261836 4306 719745 SGTC_264 promethazine 12.5 mM -1.46610280767998 0.0892316286476221 no 3103 0.0713101404774485 4345 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2891 9063876 19.48 µM -1.46629642772919 0.089203040149983 no 3104 0.0712837741284334 4505 6472478 SGTC_2212 7123476 200 µM -1.46662414437272 0.0891546674770102 no 3105 0.0712391641337487 4499 1085715 SGTC_2444 5485484 36.41 µM -1.46741768292065 0.089037617944204 no 3106 0.0711312335330012 4532 6790631 SGTC_326 k292-0812 17.5 µM -1.47523938118937 0.087890005998133 no 3107 0.0700740986454834 4466 3579357 SGTC_3018 9082602 49.47 µM -1.47837443302054 0.0874331361135701 no 3108 0.0696537923939049 4401 17332089 SGTC_1632 st005650 90 µM -1.48011802902515 0.0871798108388424 no 3109 0.0694208754700044 4504 2759605 SGTC_130 0136-0219 337.655 µM -1.48857982772162 0.0859581846821692 no 3110 0.0682990234050274 4371 234244 SGTC_1986 st071812 45 µM -1.49203824812378 0.0854625983420285 no 3111 0.0678445593636116 4426 11838594 SGTC_2010 4012422 159 µM -1.4949019456272 0.0850538570270418 no 3112 0.0674700172220003 4440 952393 SGTC_1835 st008666 49.2 µM -1.4955410844676 0.084962831772787 no 3113 0.0673866429721664 4446 690455 SGTC_2063 5246145 200 µM -1.49767304426922 0.084659729090583 no 3114 0.0671091092965552 4529 711240 SGTC_601 0986-0029 62.9 µM -1.49832273899291 0.084567522812494 no 3115 0.0670247094786817 4468 24747981 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.50094234318613 0.0841965062473098 no 3116 0.0666852374822697 4515 23665772 A membrane-active detergent. SGTC_121 0557-0495 61.343 µM -1.50105307072917 0.0841808507757982 no 3117 0.0666709177706075 4530 3104427 SGTC_2819 7996655 46.38 µM -1.50490450373343 0.0836376657951201 no 3118 0.0661743151280313 4465 6456960 SGTC_3058 9093861 49.47 µM -1.5081112041102 0.0831874228899499 no 3119 0.0657630340696103 4498 17217477 SGTC_685 1278-0033 54.9 µM -1.50895399735274 0.0830693918793047 no 3120 0.0656552696155018 4557 3590572 SGTC_1682 st012968 530 nM -1.51044386168205 0.0828610484271378 no 3121 0.0654651018808152 4480 24207270 SGTC_2347 9049783 174.81 µM -1.51973904671306 0.081570073556574 no 3122 0.064288286923022 4474 6467988 YPL169C MEX67 SGTC_3176 9106582 49.47 µM -1.52142679994307 0.0813373032963425 no 3123 0.0640763838679068 4527 17018027 SGTC_2125 5246583 200 µM -1.52196903604845 0.0812626260406156 no 3124 0.0640084196926781 4507 835267 SGTC_3312 9133330 71.43 µM -1.52590710819994 0.0807218223822318 no 3125 0.0635165000976699 4514 17617324 SGTC_1856 st057054 55.7 µM -1.52700294328423 0.0805718190706548 no 3126 0.063380139743281 4483 1266018 SGTC_226 1,3-diallylurea 8.28947 mM -1.53529062880092 0.0794441702176596 no 3127 0.0623562275087 4487 74537 YKL182W FAS1 SGTC_1684 st024538 14.6195 µM -1.53939408749739 0.078890280706739 no 3128 0.0618540582950541 4488 6732859 SGTC_1257 0669-0121 16 µM -1.54117061329505 0.0786513926671735 no 3129 0.0616376338019887 4504 4307855 SGTC_2064 5220758 200 µM -1.54740482412377 0.077817419710081 no 3130 0.06088282935189 4542 788518 SGTC_323 4013-0906 34.3 µM -1.54985947126568 0.0774909004611397 no 3131 0.0605876245518436 4541 2910086 SGTC_1370 2001-0092 44.6 µM -1.5526906727457 0.0771155849142191 no 3132 0.060248525852401 4501 790957 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.56140654704968 0.075968843881038 no 3133 0.059213929053778 4475 6708630 An antioxidant. SGTC_383 2324-0395 7.37 µM -1.56274008378819 0.0757945427025048 no 3134 0.0590568710880269 4504 3146421 SGTC_1084 voriconazole 435 nM -1.56356491593955 0.0756868848035026 no 3135 0.0589598897516472 4550 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2918 7977171 22.06 µM -1.56625156716772 0.0753370280562678 no 3136 0.0586448673348258 4509 2236483 SGTC_3093 9117344 49.47 µM -1.56792771154082 0.0751193851580243 no 3137 0.0584490018567741 4547 24824913 SGTC_3218 9131285 49.47 µM -1.57201732404815 0.0745903721232384 no 3138 0.0579732667802677 4514 17156417 SGTC_3226 9131256 49.47 µM -1.57500469386362 0.0742057406469528 no 3139 0.0576276805521832 4548 17178073 SGTC_357 1325-0123 420 µM -1.57694506125376 0.0739567260856209 no 3140 0.0574040834228728 4529 1098503 SGTC_2742 clothiapine 36.27 µM -1.58004007577995 0.07356085352339 no 3141 0.0570488445138567 4578 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1609 st001574 46.4 µM -1.58132260062563 0.0733972858324047 no 3142 0.0569021472882814 4523 3960012 SGTC_2003 4023581 200 µM -1.58286747769612 0.0732006283904704 no 3143 0.0567258363942744 4546 16641307 SGTC_2648 atorvastatin 78.68 µM -1.58474427981032 0.0729622607278375 no 3144 0.0565122234380374 4525 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2020 4017018 200 µM -1.58663481301022 0.0727227502378766 no 3145 0.0562976890145092 4556 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_768 0384-0033 77.3 µM -1.58666793656771 0.0727185592077854 no 3146 0.0562939359417374 4497 3965305 YMR134W ERG29 SGTC_2998 9066762 71.4286 µM -1.58791230654868 0.0725612465419472 no 3147 0.0561530851322776 4547 4945196 SGTC_3042 9091578 49.47 µM -1.59101274048949 0.0721704250609407 no 3148 0.0558033542737954 4529 25236497 SGTC_698 k064-0052 127 µM -1.59276602396604 0.0719501323185586 no 3149 0.0556063448937794 4625 5088751 SGTC_1216 1165-0504 9.65 µM -1.59554933984973 0.0716014797360244 no 3150 0.0552947229087675 4572 6304004 SGTC_1106 tegaserod maleate 11.7 µM -1.5974382850429 0.0713656000342529 no 3151 0.0550840220695339 4572 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2616 abietic acid 100 µM -1.59981735063872 0.0710693663643191 no 3152 0.0548195542796658 4574 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1460 k062-0059 9.15 µM -1.60214280507469 0.0707807217133081 no 3153 0.0545620171327904 4432 1373085 SGTC_3021 9087658 49.47 µM -1.60376638447326 0.070579731150185 no 3154 0.0543827784360474 4570 25237042 SGTC_938 3126-1755 342 µM -1.60561828343537 0.0703510117033588 no 3155 0.0541789028763652 4535 1777771 SGTC_2041 5107442 45.335 µM -1.60567678170309 0.0703437961504223 no 3156 0.0541724726701422 4561 793005 SGTC_2056 5235370 200 µM -1.60832678701613 0.0700175238594703 no 3157 0.0538818134586836 4479 5511916 SGTC_2906 7926292 26.41 µM -1.61009620148844 0.0698003202060873 no 3158 0.0536884281103534 4534 2966319 SGTC_1421 4029-0249 71.4 µM -1.61130020763109 0.0696528197441003 no 3159 0.0535571527718979 4625 2894095 SGTC_3105 9121040 49.47 µM -1.61431405594527 0.0692846511976449 no 3160 0.053229661402598 4531 41448907 SGTC_3168 9103419 49.47 µM -1.61861068065683 0.06876237445555 no 3161 0.0527655277959834 4585 16649256 SGTC_3011 9081274 71.4286 µM -1.62109267280166 0.0684620619062802 no 3162 0.0524988825902597 4568 6625322 SGTC_2767 sibutramine 71.45 µM -1.62457880512438 0.0680419618285548 no 3163 0.0521261681465935 4547 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2211 7117706 200 µM -1.62540323743861 0.0679429043231965 no 3164 0.052038333270029 4537 822771 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.63701357814832 0.0665596927194099 no 3165 0.0508138162440263 4576 616764 SGTC_3076 9116187 49.47 µM -1.63746554233871 0.0665062915157271 no 3166 0.0507666165342309 4565 27241210 SGTC_329 k048-0121 21.3 µM -1.63838749492158 0.0663974623242046 no 3167 0.0506704430507819 4563 6832902 SGTC_3341 9147222 25.867 µM -1.63921874356948 0.0662994582662425 no 3168 0.0505838557944787 4565 1939759 SGTC_2975 9084847 53.72 µM -1.6408842049999 0.0661034377907782 no 3169 0.0504107271821186 4549 27211724 SGTC_811 0416-0114 265 µM -1.64171533382925 0.0660057841708017 no 3170 0.0503245061740435 4577 6612453 SGTC_2087 5276107 200 µM -1.6426646587321 0.0658943798758294 no 3171 0.0502261673757522 4559 144405 SGTC_1957 st077035 62.4 µM -1.64664565831693 0.0654287914404576 no 3172 0.0498154499226297 4582 705593 SGTC_838 0109-0203 71.4 µM -1.65144445775319 0.0648709553792356 no 3173 0.0493239266134728 4602 759422 SGTC_1590 st077108 57.8 µM -1.65743643142488 0.0641796108664674 no 3174 0.0487156354804847 4583 5489485 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.66238452492339 0.0636130365156733 no 3175 0.0482178498670384 4522 4000243 SGTC_237 nikkomycin 200 µM -1.66338622402442 0.0634988135032087 no 3176 0.0481175744476083 4594 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3040 9091894 49.47 µM -1.66433773842042 0.0633904609002586 no 3177 0.0480224773924203 4483 25236966 SGTC_1298 1079-1278 263 µM -1.66520768476883 0.0632915227567896 no 3178 0.0479356641672926 4548 2840950 SGTC_2669 eugenol 100 µM -1.6661539575736 0.0631840406318623 no 3179 0.0478413769017457 4610 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1728 st035614 33.7865 µM -1.6866605305784 0.0608895522440383 no 3180 0.0458343227898335 4531 15945546 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.68830731846203 0.0607081558447703 no 3181 0.0456761255496366 4562 6708760 SGTC_3095 9117207 49.47 µM -1.69425441782806 0.0600565904333457 no 3182 0.0451084740921819 4598 17015229 SGTC_1994 st072947 40.9 µM -1.70876534304267 0.058489750162934 no 3183 0.0437472123981181 4637 5286565 YDL195W SEC31 SGTC_2116 5511452 16.8835 µM -1.72423503615221 0.0568549251742784 no 3184 0.0423327107874011 4599 870744 SGTC_1820 st053765 18.6 µM -1.72538884444789 0.056734448378616 no 3185 0.0422287101764851 4622 3690829 SGTC_1687 st020778 55.3625 µM -1.72805487293262 0.0564568397848172 no 3186 0.0419891934987331 4625 4259299 SGTC_1965 Pectolinarigenin 58.4 µM -1.73162422290626 0.0560868473743689 no 3187 0.0416702452462743 4598 5320438 An anti-inflammatory. SGTC_684 1140-0066 328 µM -1.73203300703625 0.0560445958686387 no 3188 0.0416338428893922 4613 6813534 SGTC_418 lividomycin a 100 µM -1.73221293212109 0.0560260069555228 no 3189 0.0416178286698724 4618 72394 An antibiotic. SGTC_1306 1185-0270 9.02 µM -1.73770587217427 0.0554608421941398 no 3190 0.0411313267488612 4612 1548076 SGTC_2693 st077581 40.7 µM -1.73797870489151 0.0554328883950552 no 3191 0.0411072830631627 4558 25238761 SGTC_2182 6325192 200 µM -1.7382257311229 0.0554075882648413 no 3192 0.041085523434803 4625 736248 SGTC_2985 9022375 71.43 µM -1.74051487380255 0.0551735705257979 no 3193 0.0408843253266761 4607 4939335 SGTC_1666 st014829 29 µM -1.74076584928583 0.0551479610099593 no 3194 0.0408623152078077 4626 3858230 SGTC_3166 9102297 49.47 µM -1.74889615722477 0.0543234130547775 no 3195 0.0401544854842093 4616 25237072 SGTC_2253 7938677 135.83 µM -1.74932817826917 0.0542798733535657 no 3196 0.0401171539236652 4634 2301972 SGTC_2407 paclitaxel 400 µM -1.75117954769481 0.0540936022894598 no 3197 0.0399574936380116 4619 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_382 3229-0966 23.2 µM -1.75244883694643 0.0539661884115262 no 3198 0.039848330056847 4626 5722370 SGTC_2797 7859098 81.82 µM -1.75338206569371 0.0538726606302465 no 3199 0.0397682236691842 4567 972681 SGTC_2109 5483026 200 µM -1.75695691728728 0.053515577482301 no 3200 0.0394625764541743 4610 759335 SGTC_2921 7974240 10.71 µM -1.75992497708299 0.0532205323293674 no 3201 0.0392102638773135 4647 2979074 YDR527W RBA50 SGTC_1070 indatraline 8.81 µM -1.76234600573006 0.052980821924425 no 3202 0.0390054276722412 4652 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_661 1304-0007 33.6 µM -1.77106092102474 0.0521250242568623 no 3203 0.038275285804784 4631 3117130 SGTC_1140 3229-1848 2.98 µM -1.77165326310033 0.0520672575976436 no 3204 0.0382260661602655 4616 2849525 SGTC_56 0957-0365 83.25 µM -1.77211875228946 0.0520218976402496 no 3205 0.038187423365068 4564 6752360 SGTC_1907 st060210 83.7 µM -1.78153628216107 0.0511109243872959 no 3206 0.0374124415716818 4611 688793 SGTC_2433 5607874 27.82 µM -1.78685149204323 0.0506024070446254 no 3207 0.0369807471839181 4583 2252428 SGTC_133 0724-0033 378.92 µM -1.79851995407411 0.0495001955522443 no 3208 0.0360473247174772 4554 280309 SGTC_1882 5615643 20 µM -1.79863582391206 0.0494893472696745 no 3209 0.0360381533377945 4616 2253075 SGTC_301 4119-0100 24.5 µM -1.79915461633208 0.0494407987352567 no 3210 0.0359971130863721 4632 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1776 st049249 45.9 µM -1.80101609811664 0.0492669143430123 no 3211 0.0358501713361128 4632 1822314 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.80247592175923 0.0491308914968916 no 3212 0.0357352798322052 4641 5024745 SGTC_3144 9087057 49.47 µM -1.80864437567909 0.0485594381965111 no 3213 0.0352531348654128 4556 17249618 SGTC_1182 1222-0449 220 µM -1.81868749527193 0.047640413449842 no 3214 0.0344795602833476 4640 658318 SGTC_2071 5230951 39.92 µM -1.82184947257752 0.0473539683499467 no 3215 0.0342389143747245 4669 1799272 SGTC_1966 st070145 16.1 µM -1.82495397862847 0.0470740739809695 no 3216 0.0340039872464009 4613 3748532 SGTC_3190 9110366 49.47 µM -1.83571480060184 0.0461141587097382 no 3217 0.033199923912932 4638 17123768 SGTC_2696 st077691 74.316 µM -1.8430069049978 0.0454726525317195 no 3218 0.0326640011637989 4628 757133 SGTC_205 1486-1330 71.903 µM -1.84543505565972 0.045260641202274 no 3219 0.0324871388137573 4716 4118834 SGTC_3231 9132313 49.47 µM -1.84748837307172 0.0450819792372781 no 3220 0.032338195844995 4613 4905967 SGTC_1164 k060-0068 93.7 µM -1.85100092958778 0.0447776631566061 no 3221 0.0320847096854752 4639 5963676 SGTC_1799 st045822 46.1415 µM -1.85546853236919 0.0443929973288902 no 3222 0.0317646743987908 4635 3674992 SGTC_880 0833-0487 87.2 µM -1.86495437755049 0.0435850837830376 no 3223 0.0310938996752166 4642 76075 SGTC_1828 st055811 49 µM -1.86887273128499 0.0432548379720312 no 3224 0.0308202614670294 4644 5877589 SGTC_289 k017-0060 526 µM -1.87405563618252 0.0428211209073157 no 3225 0.0304613785706928 4648 5512909 SGTC_2462 5162487 171.77 µM -1.87571910723203 0.0426826653734527 no 3226 0.0303469303934042 4645 2259986 SGTC_1572 epiandrosterone 68.9 µM -1.88594765146564 0.0418392497354517 no 3227 0.0296510046436236 4618 441302 A steroid. SGTC_1826 st055655 41.6 µM -1.89360190738929 0.0412169717162191 no 3228 0.0291389350775184 4655 676168 SGTC_876 0720-0963 56.8 µM -1.89630752775476 0.0409988125000559 no 3229 0.0289596957260837 4662 765861 SGTC_112 phenothiazine 287.218 µM -1.89912522353743 0.0407726129203496 no 3230 0.0287740067063186 4624 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_939 1165-0479 45.3 µM -1.90567725915429 0.040250541156031 no 3231 0.0283460457483733 4642 1377347 SGTC_2709 st078560 56 µM -1.90687396671721 0.0401557754470206 no 3232 0.0282684550436824 4630 17250903 SGTC_1792 st045773 43.6 µM -1.91003971948169 0.0399059573547539 no 3233 0.0280640497093051 4638 2919270 SGTC_3048 9093155 49.47 µM -1.91457725511431 0.0395500925037571 no 3234 0.0277732190409 4670 25236002 SGTC_1798 st045719 60.953 µM -1.9180309189313 0.0392809658532106 no 3235 0.0275535453899245 4644 3980186 SGTC_2555 cholic acid 100 µM -1.91848947962655 0.0392453448612671 no 3236 0.0275244874125211 4625 6708657 Influences liver metabolism. SGTC_3342 9147791 14.508 µM -1.9245877333755 0.0387741272527829 no 3237 0.0271404776141037 4624 1838168 SGTC_1711 st032263 62.8 µM -1.93243722916657 0.038174384485889 no 3238 0.026652781336244 4668 3958979 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.93524926109011 0.0379613797533107 no 3239 0.0264798576933345 4675 94937 An inhibitor of serotonin biosynthesis. SGTC_471 1-acyl-paf 4 µM -1.93578447260226 0.0379209488030816 no 3240 0.0264470517155858 4647 16759367 SGTC_3230 9131665 49.47 µM -1.94156268612795 0.0374866843794534 no 3241 0.0260950318832567 4693 15943720 SGTC_4 0960-0234 25.671 µM -1.94391281010478 0.0373112254303553 no 3242 0.0259529831077522 4626 6821112 SGTC_1830 st055982 50.3 µM -1.94462937494582 0.0372578607603735 no 3243 0.0259098006118473 4662 455313 An antimicrobial agent. SGTC_2 0422-0095 29 µM -1.96749607693854 0.0355873956345868 no 3244 0.0245630238753986 4613 6790840 SGTC_2524 avocatin b 10.57 µM -1.96962817390828 0.0354348207425134 no 3245 0.0244405001291886 4700 6710748 SGTC_516 3992-2719 87.3 µM -1.97770377139663 0.034861779406617 no 3246 0.0239810672827628 4586 5350887 YDR037W KRS1 SGTC_2604 4'-hydroxychalcone 11.32 µM -1.97972808457861 0.0347193337046193 no 3247 0.0238670455172927 4642 5282362 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.98044022082302 0.0346693362990203 no 3248 0.0238270421293039 4673 803109 SGTC_1935 st074532 41.6 µM -1.98125923843683 0.0346119081282154 no 3249 0.0237811045128083 4650 2829742 SGTC_495 decylubiquinone 155 µM -1.98150682726936 0.0345945629936555 no 3250 0.0237672322474382 4679 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1153 4055-0057 267 µM -1.98661914451802 0.0342380063220168 no 3251 0.0234823090240519 4711 882706 SGTC_2898 9056270 58.44 µM -1.98779375616436 0.0341565116642501 no 3252 0.0234172522876832 4696 19154699 SGTC_1748 st037455 53.6035 µM -1.98873699508723 0.0340911851728896 no 3253 0.0233651201507921 4668 580690 SGTC_2594 a-mangostin 100 µM -1.99339729320657 0.0337699299613285 no 3254 0.0231089800247051 4658 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1472 k841-0093 193 µM -1.99486831424628 0.0336690446001471 no 3255 0.0230286220819535 4713 X1472 SGTC_2740 felodipine 17.08 µM -1.99921438844642 0.0333724307493708 no 3256 0.0227925812107941 4729 3333 L-type calcium channel blocker SGTC_2641 levomentholum 100 µM -2.00879367120041 0.0327262514993544 no 3257 0.0222795098596133 4698 16666 SGTC_2258 7960471 200 µM -2.01271116206227 0.0324649825631404 no 3258 0.0220725122151494 4704 2974708 SGTC_954 1189-0853 2.85 µM -2.01426635363758 0.03236174055684 no 3259 0.0219907882490007 4641 2828194 SGTC_633 0437-0093 97.7 µM -2.0160505713911 0.0322436284105351 no 3260 0.0218973439596289 4645 2831118 SGTC_2305 7443522 69.23 µM -2.01897624390166 0.0320507240980591 no 3261 0.0217448443497011 4617 5415886 SGTC_1461 k072-0203 53.8 µM -2.01910365202835 0.0320423451385513 no 3262 0.021738223684536 4566 5418714 SGTC_110 0850-0284 111.64 µM -2.0272979055633 0.0315072392156851 no 3263 0.0213159777934593 4668 3906265 SGTC_2107 5363541 170.161 µM -2.02923070175275 0.0313821051590203 no 3264 0.0212173989228171 4640 244052 SGTC_2124 5246320 200 µM -2.03078835901112 0.0312815578148456 no 3265 0.0211382342103714 4670 579342 SGTC_1327 1436-0082 2.18 µM -2.03306047714244 0.0311353696392779 no 3266 0.0210232066802215 4709 15992205 SGTC_3086 9117350 49.47 µM -2.03574412712547 0.0309634319463532 no 3267 0.0208880277748461 4698 2679265 SGTC_2412 st077135 33.4 µM -2.04058328400578 0.0306553800066234 no 3268 0.0206461325480584 4670 13258915 SGTC_3073 9114972 49.47 µM -2.04328480724511 0.0304845127061227 no 3269 0.0205121263352788 4694 41905075 SGTC_2361 9034121 116 µM -2.05576919023603 0.0297051103700339 no 3270 0.0199023845445583 4703 6496917 SGTC_2541 muurolladie-3-one 83.07 µM -2.05814721716849 0.0295585405392015 no 3271 0.0197880018146633 4647 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1403 3909-7815 62.9 µM -2.05831429419761 0.0295482653451451 no 3272 0.0197799864562167 4715 6615483 SGTC_225 nsc-122657 1.016 µM -2.0625016165979 0.029291712827514 no 3273 0.0195800019029847 4712 275685 SGTC_566 0958-0068 16.5 µM -2.06384444500872 0.0292098320446836 no 3274 0.0195162337652704 4631 6815365 SGTC_2770 toltrazuril 17.5 µM -2.0642122466733 0.0291874380379534 no 3275 0.0194987984316181 4649 68591 Kills coccidiodes. SGTC_567 1080-0542 68.4 µM -2.06615227222 0.0290695533439336 no 3276 0.0194070519153102 4621 5950415 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -2.07674208558699 0.0284330217697756 no 3277 0.0189126850166519 4705 5357218 A potent inhibitor of glutathione S-transferases. SGTC_704 1310-0270 142 µM -2.07697517451053 0.0284191427719729 no 3278 0.0189019252849837 4687 5718033 SGTC_1085 doxorubicin 7.67 µM -2.07761899343572 0.0283808366390223 no 3279 0.0188722326970239 4718 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2972 9093619 59.92 µM -2.08537917191674 0.0279224898487523 no 3280 0.0185174479616223 4673 25236256 SGTC_1064 honokiol 6.76 µM -2.08689742559044 0.0278335408186919 no 3281 0.0184487038322165 4693 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_17 0960-0276 49.807 µM -2.09139636554795 0.02757134925585 no 3282 0.0182462738597703 4706 6821114 SGTC_1270 0831-1170 17.3 µM -2.10502261137223 0.0267897639958183 no 3283 0.0176446699252259 4720 6764716 SGTC_1742 st038235 28.8875 µM -2.12513545950534 0.0256699876911594 no 3284 0.0167876557577595 4714 564103 YBR002C RER2 SGTC_3056 9094900 49.47 µM -2.12581641842669 0.0256327718519542 no 3285 0.0167592742007131 4684 25236784 SGTC_2114 5491910 81.25 µM -2.12652300677682 0.0255942030733966 no 3286 0.0167298678411031 4717 2849228 SGTC_86 0417-1630 471.922 µM -2.1265699573421 0.0255916420222802 no 3287 0.0167279154462622 4727 3634867 SGTC_831 k061-1017 217 µM -2.14034940751342 0.0248492196916279 no 3288 0.016163269946702 4736 1240153 SGTC_1400 3771-8998 51.5 µM -2.14459931259546 0.024623916575491 no 3289 0.0159924486596646 4717 670767 SGTC_2416 tofa 880 nM -2.17527908646738 0.0230477971323781 no 3290 0.014804604376232 4692 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2430 5571206 200 µM -2.17936373099946 0.0228445085290365 no 3291 0.0146523291177081 4685 1731771 SGTC_1432 4049-0298 68.4 µM -2.18195284182595 0.0227164350450917 no 3292 0.014556506665768 4747 741646 SGTC_1384 3089-0840 101 µM -2.18359533031651 0.0226355015054822 no 3293 0.0144959985030071 4725 1069836 SGTC_2932 9016711 44.54 µM -2.1910507955008 0.0222711830973965 no 3294 0.0142240584184065 4693 7117328 SGTC_512 prima-1 270 µM -2.20692382303935 0.0215119888445849 no 3295 0.0136596908789568 4739 322968 A re-activator of the apoptotic function of mutant p53. SGTC_456 gingerol 170 µM -2.20978746466317 0.0213773788753871 no 3296 0.0135599580544559 4717 442793 A herb. SGTC_526 4469-0568 170 µM -2.21629902725842 0.021073941535565 no 3297 0.0133355148059338 4701 2901964 SGTC_2336 9001819 198.65 µM -2.23895256584568 0.0200465320346858 no 3298 0.0125795013381067 4698 2989602 SGTC_3314 9135860 59.4275 µM -2.24705245442626 0.0196896375562097 no 3299 0.0123183375003681 4712 25252478 SGTC_2738 aclarubicin 5.55 µM -2.26167331112224 0.0190590694155456 no 3300 0.011858797425726 4776 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_804 1595-0054 20.9 µM -2.26211530488533 0.0190402776562175 no 3301 0.0118451401234843 4727 761523 Stimulates phospholipase C. SGTC_2531 methyl deoxycholate 70.07 µM -2.27112212636765 0.0186607627251201 no 3302 0.0115697929466011 4676 16667744 Haematoxylin. SGTC_319 1348-1596 45.5 µM -2.28246461763388 0.018192007998535 no 3303 0.011230962065908 4768 5380505 SGTC_1239 0337-0584 35.4 µM -2.28300432749537 0.0181699556129285 no 3304 0.0112150567262021 4731 914301 YML130C ERO1 SGTC_2852 9023854 51.95 µM -2.30209247854762 0.0174045403856524 no 3305 0.0106649787507732 4727 19798528 SGTC_2967 9089538 49.85 µM -2.31201141551301 0.0170177902790143 no 3306 0.0103885271185935 4713 728216 SGTC_2853 9015042 58.44 µM -2.34361439590734 0.0158341744448134 no 3307 0.00954895231136068 4691 6457456 SGTC_2707 st078556 66.6 µM -2.38879287565155 0.0142650990420971 no 3308 0.00845191460979439 4716 17250899 SGTC_328 k915-0120 63.5 µM -2.39020255254148 0.0142183755693293 no 3309 0.00841954150448786 4771 6624543 SGTC_3340 9146634 11.102 µM -2.39485095069943 0.0140652382268264 no 3310 0.00831356138245758 4739 4907387 SGTC_3126 9127922 49.47 µM -2.39770884675799 0.0139717947286197 no 3311 0.00824898650809772 4701 45595682 SGTC_927 2425-1185 123 µM -2.40019214551313 0.0138910343233325 no 3312 0.00819323390811993 4730 730375 SGTC_3151 9099821 49.47 µM -2.4054124643078 0.0137225737478379 no 3313 0.00807711076814853 4714 17174189 SGTC_2916 7875993 68.79 µM -2.41154335390369 0.0135269819626476 no 3314 0.00794258157750733 4699 1299250 SGTC_1145 3546-0597 10.2 µM -2.41624014564258 0.0133787740881122 no 3315 0.0078408574863523 4744 875334 SGTC_756 0508-1999 28.3 µM -2.43566107003631 0.0127807361893908 no 3316 0.00743230254403305 4755 6753853 SGTC_392 N-ethylmaleimide 8.33 µM -2.44753272643032 0.0124266721606536 no 3317 0.00719190309347703 4750 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_330 1488-0319 80.1 µM -2.48570023529719 0.0113452994542233 no 3318 0.00646484129937469 4774 6846614 SGTC_1817 st052116 64.4 µM -2.49369121504049 0.0111295464620427 no 3319 0.00632112351457412 4774 4361398 SGTC_3065 9113888 49.47 µM -2.49798698462615 0.0110150438399443 no 3320 0.0062450389752548 4751 16648368 SGTC_230 MPP+ 141.667 µM -2.51527263864661 0.0105645954567231 no 3321 0.00594701828274235 4765 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2460 5552655 174.22 µM -2.53744988787657 0.0100102385087657 no 3322 0.00558316766910572 4744 5401989 SGTC_598 3937-0236 20.2 µM -2.54201866963147 0.00989924190023227 no 3323 0.00551071431394728 4786 1379313 SGTC_5 0352-0601 109.883 µM -2.56557705784376 0.00934379534071939 no 3324 0.00515021696183512 4699 762456 SGTC_1449 4112-4002 201 µM -2.57633086188203 0.00909944471073075 no 3325 0.00499275227847162 4784 2059539 SGTC_368 fentichlor 4.58 µM -2.58969429389544 0.0088036075444336 no 3326 0.00480305984620679 4754 7329 A pesticide. SGTC_3200 9114385 49.47 µM -2.61667393374738 0.00823192607416482 no 3327 0.00443955571274868 4735 17018030 YLR208W SEC13 SGTC_959 1222-0044 107 µM -2.62020698179713 0.00815953156039392 no 3328 0.00439382063611489 4771 6083612 SGTC_2814 7977482 42.97 µM -2.63562374339742 0.00785013815731223 no 3329 0.00419913989561952 4754 6456762 SGTC_22 0964-0034 14.468 µM -2.69146185658019 0.00681421784332979 no 3330 0.00355698164043128 4774 138402 SGTC_1173 0443-0020 122 µM -2.70061214922941 0.0066565000061146 no 3331 0.0034605999050721 4775 5331295 SGTC_3132 9126706 49.47 µM -2.72387326238145 0.00627000113274901 no 3332 0.0032260630372255 4769 850858 SGTC_2077 5212015 200 µM -2.78170180050043 0.0053939477813974 no 3333 0.00270373502842395 4771 780900 SGTC_378 3970-0959 8.33 µM -2.82999712066062 0.00474755260476803 no 3334 0.00232742115239662 4779 6615653 SGTC_1108 betulinic acid 729.144 nM -2.83853077037585 0.00464080775072632 no 3335 0.00226608746953914 4758 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1522 st012842 45.6 µM -2.8653326177768 0.0043193405432384 no 3336 0.00208285716353056 4715 3491067 YOR116C RPO31 SGTC_1031 k035-0009 16 µM -2.88498807465505 0.00409639579838045 no 3337 0.00195714244412619 4789 5180959 SGTC_655 k060-0012 42 µM -2.95365105505857 0.00339616805644335 no 3338 0.00157019437640023 4794 5994525 SGTC_1717 st033143 58.0435 µM -2.98369749245164 0.003125128535484 no 3339 0.00142394090282089 4772 674616 SGTC_439 amiodarone 34.4 µM -3.01115305510262 0.00289465659253391 no 3340 0.00130128815605457 4738 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_716 1683-5115 658 µM -3.06038335837104 0.00251945562355139 no 3341 0.00110526922753873 4784 723597 SGTC_668 1682-0499 62.6 µM -3.07046181006646 0.00244829510091771 no 3342 0.00106864008666105 4793 682214 SGTC_3071 9117417 49.47 µM -3.0763301077813 0.00240770345999408 no 3343 0.00104782845388493 4779 45595590 YGL055W OLE1 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -3.13655863006493 0.00202494890815668 no 3344 0.000854716270912746 4791 3256 An antibiotic and ribosome inhibitor. SGTC_2931 9014674 55.67 µM -3.20433034231101 0.00166091840085681 no 3345 0.000676885252337324 4778 2996810 SGTC_967 1306-0166 352 µM -3.25878423911466 0.00141277468518738 no 3346 0.000559453641096091 4794 4437607 SGTC_3225 9130819 49.47 µM -3.31207612957007 0.00120317005776053 no 3347 0.000463031707751593 4798 4547121 SGTC_2067 5224629 34.075 µM -3.32827854111625 0.00114533251648762 no 3348 0.000436922247633475 4789 2835000 SGTC_2739 tacrine 100.86 µM -3.38705796211686 0.000956238667965555 yes 3349 0.000353232302958986 4804 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1783 st039459 87.517 µM -3.62656872804747 0.000445769381200459 yes 3350 0.000143606199664459 4806 729761 SGTC_695 3505-6186 243 µM -3.67194316845342 0.000383808048058693 yes 3351 0.000120356609580343 4804 1819379 SGTC_965 1291-5240 308 µM -3.92390984001487 0.000162315989610393 yes 3352 4.35616760663428e-05 4799 2834598 SGTC_2848 9016370 25.97 µM -4.11838695216363 8.07172820182365e-05 yes 3353 1.90766828260559e-05 4800 7894410 SGTC_1779 st039427 55 µM -4.34669044251607 3.4208852965419e-05 yes 3354 6.91035279636279e-06 4804 1124498 SGTC_2536 dehydroabietamide 32.04 µM -4.50555882149563 1.83672606182021e-05 yes 3355 3.30992488911107e-06 4808 3983547 SGTC_910 3454-3003 490 µM -5.74223768817776 7.24669734875127e-08 yes 3356 4.67167732809765e-09 4805 820824