SGTCid condition conc unit FYV6|YNL133C.score FYV6|YNL133C.strain.pval FYV6|YNL133C.strain.significant FYV6|YNL133C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2902 5787006 60.46 µM 8.58261708712888 1.201435852193e-13 yes 1 4.63693288285138e-18 1 591003 SGTC_936 3005-4620 401 µM 6.77906573485094 3.6678312025816e-09 yes 2 6.04777442917949e-12 2 777207 SGTC_2912 7964298 10.93 µM 6.7364510351989 4.55174947582419e-09 yes 3 8.11509761230986e-12 36 2975850 SGTC_2413 inermin 26.06 µM 5.97471416459691 1.73709208970535e-07 yes 4 1.15246976932291e-09 19 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2915 7971052 15.16 µM 5.80298467013647 3.73028937204682e-07 yes 5 3.25723748070749e-09 2 5741558 SGTC_3320 9137005 35.139 µM 5.70371634719814 5.74756946383641e-07 yes 6 5.86115437396984e-09 3 4908713 SGTC_3004 9076122 71.4286 µM 5.60432849287649 8.79890210169732e-07 yes 7 1.04531941689373e-08 5 44782551 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 5.50736670048291 1.32417620423146e-06 yes 8 1.82120511219565e-08 11 5711223 A potent inhibitor of glutathione S-transferases. SGTC_926 2268-1401 59.4 µM 4.99726154436537 1.01999647099905e-05 yes 9 2.9075088261271e-07 16 2931578 SGTC_740 k014-0057 261 µM 4.86401607659226 1.68719116020313e-05 yes 10 5.75137822452555e-07 9 4012779 SGTC_2251 lansoprazole 556 µM 4.82822905050887 1.92730003801116e-05 yes 11 6.88762986587165e-07 9 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2844 9010103 25.97 µM 4.69567675559578 3.13041629633155e-05 yes 12 1.32862736140267e-06 14 2480525 SGTC_355 1311-2252 105 µM 4.54118311361811 5.42526777702626e-05 yes 13 2.7969709126677e-06 10 5338538 SGTC_576 1073-0113 22.7 µM 4.26072989615255 0.000141114664819518 yes 14 1.01880182916613e-05 54 5439563 SGTC_832 4083-0019 164 µM 4.2359826017983 0.000153133570426336 yes 15 1.13777198580399e-05 75 1990758 SGTC_2166 5933061 31.504 µM 4.19692538556397 0.000174069087177442 yes 16 1.35281511156485e-05 31 2877375 SGTC_2255 7941087 197.44 µM 4.17407920368085 0.00018752642278745 yes 17 1.49596831590317e-05 25 935561 SGTC_1916 st067606 49.2 µM 4.14489946062985 0.00020613023291721 yes 18 1.69981418287285e-05 31 19590279 SGTC_2606 farnesol 9.78 µM 4.08376777124054 0.000250828464325457 yes 19 2.21556575023498e-05 17 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1496 4469-0713 57.4 µM 4.04081169934428 0.000287475984601564 yes 20 2.66332579455289e-05 16 746691 SGTC_2628 lathosterol 100 µM 3.96422644002432 0.000365447626268862 yes 21 3.68171662237963e-05 31 6710616 SGTC_397 arbidol 50 µM 3.89178264114767 0.000456881238416816 yes 22 4.97551878856502e-05 21 131410 A RNA synthesis inhibitor. SGTC_2881 9058953 51.95 µM 3.80093891527216 0.000601458723281596 yes 23 7.20744189585915e-05 23 17122249 SGTC_129 0088-0017 176.636 µM 3.73331774002412 0.000735349640527163 yes 24 9.44869768944943e-05 71 182446 SGTC_1679 SEC14.276 6.7 µM 3.72529697985508 0.000752934884870416 yes 25 9.75427048698032e-05 76 1005053 YMR079W SEC14 SGTC_1360 1598-0022 39.8 µM 3.71665346507831 0.000772318607343111 yes 26 0.000100939518188122 38 761525 SGTC_3007 9078383 71.4286 µM 3.64754553638829 0.000944630817558888 yes 27 0.000132378699970698 27 6496995 SGTC_528 3492-0019 172 µM 3.64675825291181 0.000946782850170638 yes 28 0.000132784778667191 248 2869262 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 3.64367061902014 0.000955266402702622 yes 29 0.000134388669666192 25 688667 SGTC_2424 5537928 59.2 µM 3.56707902774092 0.00118938863508576 no 30 0.000180491320293818 47 5382802 SGTC_1060 3448-7350 82 µM 3.53903902299848 0.00128748712803153 no 31 0.000200793241539466 45 570178 SGTC_2550 chrysin dimethyl ether 71.87 µM 3.5381157945141 0.00129083940730586 no 32 0.000201496643751862 13 88881 An O-methylated flavonoid and antioxidant. SGTC_348 k064-0012 10.7 µM 3.51206438845628 0.00138878639879205 no 33 0.00022232012992364 23 5066323 SGTC_2146 5545642 200 µM 3.50587040348963 0.00141305170698613 no 34 0.000227558379495831 30 825326 SGTC_276 colchicine 750 µM 3.47008033843687 0.00156100336490573 no 35 0.000260151356430001 30 2833 A microtubule depolymerizer. SGTC_1354 1498-1681 81 µM 3.44447632689715 0.00167536832573513 no 36 0.000286083368695921 36 5754243 SGTC_1410 3909-8106 77.9 µM 3.40664655559817 0.00185834402362962 no 37 0.000328831158732957 19 1039210 SGTC_3076 9116187 49.47 µM 3.40509222845795 0.0018662366090115 no 38 0.000330708557904721 27 27241210 SGTC_957 1187-1561 14.1 µM 3.39288855338049 0.00192927123207636 no 39 0.000345798848564295 42 1538454 SGTC_1913 st060213 96.1 µM 3.3735161301304 0.00203331479112872 no 40 0.000371073490894394 58 688959 SGTC_2414 st077232 92.9 µM 3.36882513208317 0.00205926282570947 no 41 0.00037744652648057 40 729801 SGTC_1847 st056231 15 µM 3.36424299575181 0.00208489843904843 no 42 0.000383769662694052 55 5393180 SGTC_2289 7946404 165.07 µM 3.35711563510327 0.00212534961266642 no 43 0.000393800828172105 119 1246120 YPR165W RHO1 SGTC_495 decylubiquinone 155 µM 3.35467452288274 0.00213936688988193 no 44 0.000397292068844958 50 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_923 1900-2434 73.3 µM 3.33690501768706 0.00224395489515833 no 45 0.000423584472537458 48 5910570 SGTC_3149 9097855 49.47 µM 3.33659283870517 0.00224583303227976 no 46 0.000424060486299293 48 25236625 YMR079W SEC14 SGTC_2265 7929201 200 µM 3.3321992134271 0.00227241754879971 no 47 0.000430812772505609 45 1265108 SGTC_958 1222-0007 33 µM 3.31148949809634 0.00240160475328015 no 48 0.000464003615601456 53 7312461 SGTC_3058 9093861 49.47 µM 3.27810064506642 0.00262392999233943 no 49 0.000522540631252831 43 17217477 SGTC_2978 9011784 42.97 µM 3.26587200332899 0.0027098994417609 no 50 0.000545637818617634 62 2994934 SGTC_59 0330-0160 1.33 µM 3.25212505942825 0.00280957253987506 no 51 0.00057272805346092 171 4293482 SGTC_127 0180-0333 59.125 µM 3.24230501438247 0.00288278592368541 no 52 0.000592835255409159 80 771601 SGTC_2431 5490079 200 µM 3.18474959032136 0.00334754391282038 no 53 0.000724396574128824 69 5722345 SGTC_1392 3455-1037 33.9 µM 3.17909182976273 0.00339668452281945 no 54 0.000738686393707962 42 981132 SGTC_2468 5987765 72.9 µM 3.17276429064471 0.00345240963626855 no 55 0.000754975291815069 41 26772094 SGTC_1648 st011736 69.8 µM 3.16568176172977 0.00351575675447513 no 56 0.000773599819203857 39 2855514 SGTC_1545 lovastatin 49.4 µM 3.15814140249544 0.00358434414638294 no 57 0.000793892605330378 70 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_70 0141-0289 43.283 µM 3.15697581550757 0.00359505288546711 no 58 0.000797072836475491 256 352408 SGTC_2271 7849410 118.62 µM 3.14083143666352 0.00374636001966412 no 59 0.000842344824394387 33 972430 SGTC_345 1362-0200 395 µM 3.12612799028755 0.00388910531145728 no 60 0.00088562222351336 49 1419823 SGTC_2373 9071805 200 µM 3.11102929442715 0.00404074073893015 no 61 0.000932182215170122 33 10149009 SGTC_195 4234-0266 16.654 µM 3.0952557800194 0.00420478581232872 no 62 0.000983216192366184 78 2303354 SGTC_1020 4335-0961 93.3 µM 3.08913146646835 0.00427006747896632 no 63 0.00100371293752753 44 669075 SGTC_584 0986-0246 15.4 µM 3.06611496812183 0.00452358759418776 no 64 0.00108429956131084 52 53315 YDR232W HEM1 SGTC_1429 4049-0205 9.46 µM 3.03099818471876 0.00493632076210762 no 65 0.00121873356657427 40 22774478 SGTC_2254 7938975 95.19 µM 3.02365479712086 0.00502675599199941 no 66 0.0012487061330141 95 2969277 SGTC_990 3985-0011 41.3 µM 3.02077302607465 0.00506264676454768 no 67 0.00126065141214224 51 5399565 YGL099W LSG1 SGTC_1565 sinapyl alcohol 95.1 µM 3.01334308703603 0.00515623700205508 no 68 0.0012919331157918 81 5280507 A phenol propionate derived from cinnamic acid. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 2.99002595840761 0.00546002580295247 no 69 0.00139476869868905 51 4213774 SGTC_2651 TUB2.036 5 µM 2.98578982158296 0.00551689304124132 no 70 0.00141423485962189 244 15992207 YFL037W TUB2 SGTC_46 0329-0187a 2.197 µM 2.98494225620453 0.00552833399832316 no 71 0.0014181593028541 136 46494817 SGTC_2399 5884133 200 µM 2.98138602062697 0.00557656834102168 no 72 0.00143473420004338 132 722445 SGTC_467 ro 31-8220 72.8 µM 2.97240739988661 0.00570001533441314 no 73 0.0014773716263739 139 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_575 k072-0246 11.9 µM 2.95294045060763 0.00597603055456114 no 74 0.00157381338338507 72 6796779 SGTC_1133 3473-0247 50 µM 2.9527532935269 0.00597874072364873 no 75 0.00157476781185474 110 711311 SGTC_1562 morin hydrate 59.1 µM 2.92451023401139 0.0064004225128929 no 76 0.00172499367629999 66 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2845 9003024 42.97 µM 2.90711483315991 0.00667305194872476 no 77 0.00182389630489563 102 2990173 SGTC_2192 5915882 198.485 µM 2.89997707055093 0.00678785603791468 no 78 0.00186594979321098 55 2876149 SGTC_1234 0326-0494 15.5 µM 2.8996847268669 0.00679259508048648 no 79 0.00186769083207421 58 1547813 SGTC_1207 2099-0101 141 µM 2.89826772636132 0.00681560683689259 no 80 0.00187615065380584 75 5837381 SGTC_350 k064-0020 19.8 µM 2.86243396357283 0.00742088819081536 no 81 0.0021020042790268 83 2790705 SGTC_2375 9072683 200 µM 2.86008610172924 0.00746215146539704 no 82 0.00211763000988506 78 16798029 SGTC_3200 9114385 49.47 µM 2.85309343496181 0.00758624639631509 no 83 0.00216479447619267 99 17018030 YLR208W SEC13 SGTC_2406 ethylparaben 405.7 µM 2.8450870975842 0.00773055878865556 no 84 0.00221996404341537 99 8434 A possible steroid mimic. SGTC_2342 7990637 118.86 µM 2.83626013013724 0.00789245804890266 no 85 0.0022822625792817 102 2033102 YER133W GLC7 SGTC_2789 5281112 71.43 µM 2.82708254755896 0.00806394303112639 no 86 0.00234871086090449 104 765948 SGTC_1866 st057638 64 µM 2.81572907894666 0.00828061036920323 no 87 0.00243333436453322 63 688802 SGTC_850 0388-0143 75.9 µM 2.80339477559613 0.00852177450717168 no 88 0.00252838650640848 64 67273 SGTC_2543 pimpinellin 60.67 µM 2.79045191909449 0.00878144256635238 no 89 0.00263172586087964 86 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_951 1171-0579 82.7 µM 2.7863275653158 0.00886563276238102 no 90 0.00266544859518235 173 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_615 k087-0205 167 µM 2.77771040705739 0.00904382016727717 no 91 0.00273716920418055 63 9642773 SGTC_1016 4226-1401 38 µM 2.7644156312684 0.00932488536695453 no 92 0.00285124258854465 75 2901613 SGTC_3073 9114972 49.47 µM 2.76216192075406 0.00937328117855422 no 93 0.00287099970386232 64 41905075 SGTC_540 1187-0821 17.3 µM 2.75796307385108 0.00946403277259477 no 94 0.0029081383853243 78 847520 SGTC_1776 st049249 45.9 µM 2.74648701603191 0.00971600081230869 no 95 0.00301186351449205 84 1822314 SGTC_1186 1319-0216 26 µM 2.74247274916805 0.00980551139852745 no 96 0.00304892546868964 84 4565136 SGTC_1564 D-Arginine 115 µM 2.7364883968426 0.0099402882890341 no 97 0.00310493924488465 108 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_993 3909-8757 62.7 µM 2.73406338394973 0.0099953621251295 no 98 0.00312790003713928 77 4288324 YLR208W SEC13 SGTC_2190 6049624 200 µM 2.71900200269052 0.0103434180328723 no 99 0.00327396058233994 42 2265554 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 2.71221297711038 0.0105037311239493 no 100 0.00334178175255591 104 5379071 SGTC_2270 7924575 90.91 µM 2.67778599009659 0.0113504312996298 no 101 0.00370552769187577 92 1262135 SGTC_1769 st044406 64.4 µM 2.66347742472733 0.0117194211981215 no 102 0.00386688004999041 79 670903 SGTC_1245 0418-0076 17.2 µM 2.65421593974281 0.0119637690633975 no 103 0.00397464688941225 99 6790114 SGTC_2330 7979373 200 µM 2.65270770305073 0.0120039767549335 no 104 0.00399244920814007 111 1863007 SGTC_2863 9028737 58.44 µM 2.65121164358435 0.0120439755304437 no 105 0.00401017829972903 44 6460917 SGTC_3024 9090631 49.47 µM 2.6511348011533 0.0120460331129744 no 106 0.00401109082337169 49 25236383 SGTC_3292 9120825 59.784 µM 2.6330873648231 0.0125378032700779 no 107 0.00423062898291503 86 24824900 SGTC_2391 6285546 200 µM 2.62386438899015 0.0127957620772707 no 108 0.00434691963918533 105 846083 SGTC_1329 1447-1697 50.6 µM 2.60070025836433 0.0134639774619546 no 109 0.00465168509016375 89 2840515 SGTC_592 k241-0073 46.5 µM 2.59368953080392 0.0136720649206736 no 110 0.00474760938992988 93 4230158 SGTC_347 4534-1311 26.2 µM 2.57930452982295 0.0141077320338557 no 111 0.00494997346460321 89 2862016 SGTC_830 4076-0286 57.8 µM 2.57582717168999 0.014214826002123 no 112 0.00500003082621663 222 6866659 SGTC_486 niguldipine 82 µM 2.55522947547834 0.0148636509948301 no 113 0.00530589063721933 72 1236 A calcium channel blocker. SGTC_1557 sumaresinolic acid 42.3 µM 2.54994788423692 0.0150340660560949 no 114 0.00538695116208423 107 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2078 5212016 200 µM 2.54857055954628 0.0150787817051636 no 115 0.0054082701660059 80 1899708 SGTC_2837 9008476 45.46 µM 2.53483172346538 0.0155311122141412 no 116 0.0056250677044291 148 2992805 SGTC_1622 st003707 19.4 µM 2.53466632564552 0.0155366278713817 no 117 0.00562772401661803 164 10140899 SGTC_2439 5492030 7.2 µM 2.53443387423835 0.0155443824614099 no 118 0.00563145910161874 93 5722370 SGTC_1511 0906-3109 28.5 µM 2.53036420856395 0.0156806858294515 no 119 0.00569720904967355 184 2882180 SGTC_767 0929-0023 86 µM 2.52473693896805 0.0158708456134177 no 120 0.00578924619549057 224 1204563 SGTC_2292 7671323 168.05 µM 2.50132013588294 0.016683539096712 no 121 0.00618656373655831 147 937504 SGTC_2000 st075254 36.4 µM 2.49681975667775 0.0168437403529474 no 122 0.00626563168068925 73 17234175 SGTC_1625 st003711 30.1 µM 2.49680048310347 0.0168444292590812 no 123 0.0062659722168462 132 24207034 YER133W GLC7 SGTC_2115 tiliquinol 12.7705 µM 2.48827007400714 0.0171517114476716 no 124 0.00641831053324574 82 71208 A bioactive hydroxyquinoline. SGTC_2594 a-mangostin 100 µM 2.48414837563795 0.0173018914819639 no 125 0.0064930843337108 126 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_365 0121-0052 13.6 µM 2.48055219738333 0.0174338395867165 no 126 0.00655895279486614 200 3101739 SGTC_3263 9137018 49.47 µM 2.47767201947739 0.0175401355448425 no 127 0.00661213225140601 107 43844957 SGTC_955 1216-0110 33 µM 2.46559589900411 0.0179918606773941 no 128 0.00683927770184689 195 3619719 SGTC_1627 st003713 25.6 µM 2.4545909638207 0.0184121183908324 no 129 0.00705224874710652 242 16195070 YER133W GLC7 SGTC_1470 k295-0292 231 µM 2.45359091429737 0.0184507194919481 no 130 0.00707188908110056 110 5045612 SGTC_1944 st076371 56.9 µM 2.44941987725665 0.0186124621972366 no 131 0.00715432701718745 140 24208455 SGTC_1456 k015-0012 13 µM 2.44741195755673 0.0186907538605553 no 132 0.00719431370297876 137 2989616 SGTC_1466 k213-0079 57.5 µM 2.4256702830762 0.0195565930768032 no 133 0.00764007275358477 119 3657981 SGTC_2077 5212015 200 µM 2.42267414112882 0.0196785410321471 no 134 0.00770336979293498 170 780900 SGTC_1594 piperine 70.1 µM 2.42060194301856 0.0197632600978726 no 135 0.00774741700876257 133 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1055 3448-0672 86 µM 2.41616342640858 0.0199457651376682 no 136 0.00784250983612392 146 748378 SGTC_1485 3909-9022 254 µM 2.40171508310395 0.0205497930442283 no 137 0.00815920640297332 99 714516 SGTC_2541 muurolladie-3-one 83.07 µM 2.39946980541753 0.0206450365604903 no 138 0.00820941694017598 135 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1472 k841-0093 193 µM 2.39534872245205 0.0208208238010015 no 139 0.00830228228143855 139 X1472 SGTC_1412 3909-8563 178 µM 2.3935584823799 0.0208975814529354 no 140 0.00834291050879817 126 23767530 SGTC_965 1291-5240 308 µM 2.37502394490418 0.0217064343294423 no 141 0.00877390589603593 144 2834598 SGTC_2010 4012422 159 µM 2.36823491340544 0.022009255120206 no 142 0.00893659171462715 139 952393 SGTC_1368 1852-0141 284 µM 2.36723795643085 0.0220540227215036 no 143 0.00896070303268208 157 2838987 SGTC_2427 5545055 42.75 µM 2.36528503501988 0.02214193996554 no 144 0.00900809947429842 147 5372858 SGTC_857 0438-0306 1.35 µM 2.36421360180296 0.022190299618387 no 145 0.00903419579938761 105 4686136 SGTC_2581 avocatin a 64 µM 2.35425664452409 0.022643989365486 no 146 0.00927989596529913 172 6710728 A skin care supplement. SGTC_2425 5628681 7.85 µM 2.35386823225392 0.0226618447131679 no 147 0.00928959788565683 161 5714958 SGTC_948 3448-0295 75.3 µM 2.3509503521565 0.022796359746877 no 148 0.00936276609102481 164 678569 SGTC_865 0488-0499 301 µM 2.34561962850193 0.0230438450431782 no 149 0.00949774086373014 121 9634651 SGTC_1641 st009299 47.1 µM 2.34439320237817 0.0231011024254869 no 150 0.00952903384503801 73 4046054 SGTC_2911 7942208 15.64 µM 2.34132510788611 0.0232448655255963 no 151 0.00960771319079975 116 1243384 SGTC_1896 st058441 89 µM 2.33294536859785 0.0236413610712236 no 152 0.00982550640268152 121 688759 SGTC_124 0136-0217 7.121 µM 2.3230576440819 0.0241165084587542 no 153 0.0100880279811948 184 3976905 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 2.32258247120543 0.0241395431323933 no 154 0.0101007966406233 147 688664 SGTC_1190 1486-1332 13 µM 2.31713892724638 0.0244047477387185 no 155 0.0102480825464908 139 4150046 SGTC_1326 1431-2094 10.8 µM 2.31458289169233 0.0245301169349473 no 156 0.0103178850240313 161 616278 SGTC_2029 5175081 200 µM 2.30730462350426 0.0248900678529776 no 157 0.0105189219793229 161 1380876 SGTC_3055 9094636 49.47 µM 2.30236430451544 0.0251369093920448 no 158 0.0106573181092197 123 25236176 SGTC_2193 5925765 200 µM 2.29994368904472 0.0252586016525766 no 159 0.0107257052475312 105 877370 SGTC_2370 9071495 200 µM 2.29613142110038 0.0254512575261802 no 160 0.0108341841068397 171 21791103 SGTC_2204 7233102 200 µM 2.28651251805122 0.0259428325084387 no 161 0.0111121463188602 93 2172480 SGTC_3003 9075612 71.4286 µM 2.28634973630468 0.0259512193568352 no 162 0.0111169031805745 153 6501993 SGTC_8 0354-0001 70 µM 2.27831693387768 0.0263679123635059 no 163 0.0113538507279501 258 4993152 SGTC_56 0957-0365 83.25 µM 2.27775386062422 0.0263973297375297 no 164 0.0113706233617704 191 6752360 SGTC_2336 9001819 198.65 µM 2.27676500257155 0.0264490583274078 no 165 0.0114001312366604 209 2989602 SGTC_665 3914-0008 307 µM 2.27467665636019 0.026558581112034 no 166 0.0114626669198359 162 1069549 SGTC_2900 5328528 85.29 µM 2.27091518229602 0.0267568065026744 no 167 0.0115760564970047 182 795359 SGTC_1337 1486-1011 40.3 µM 2.26880985066379 0.0268682933471838 no 168 0.0116399458412339 130 X1337 SGTC_2043 5101342 149 µM 2.25903282090437 0.0273911260446708 no 169 0.0119406716759643 167 678451 SGTC_445 e6 berbamine 66 µM 2.25363853511763 0.0276832026361623 no 170 0.0121094585072819 323 6610268 A calcium/calmodulin antagonist. SGTC_969 1313-0238 134 µM 2.24760211798393 0.0280131205487863 no 171 0.0123007862019719 190 5212874 SGTC_687 k029-0044 34.9 µM 2.2456608301623 0.0281199141816519 no 172 0.0123628704604159 146 5829338 SGTC_685 1278-0033 54.9 µM 2.24563053934562 0.0281215832144866 no 173 0.012363841336712 175 3590572 SGTC_852 0418-0143 439 µM 2.24122209767504 0.028365370664589 no 174 0.0125058460788755 236 5369229 SGTC_895 0964-0006 13.7 µM 2.24032016450016 0.0284154637991966 no 175 0.0125350725371399 139 6738897 SGTC_206 4546-0025 72.014 µM 2.23890771956462 0.0284940585058572 no 176 0.0125809605522618 232 6620745 YIL048W NEO1 SGTC_2920 7982904 15.77 µM 2.2361729912825 0.0286467450128634 no 177 0.0126702208375859 158 6456808 SGTC_630 4356-0227 183 µM 2.23331330705046 0.0288071352799491 no 178 0.0127641452979178 126 779312 SGTC_1609 st001574 46.4 µM 2.23041529153516 0.0289704363686365 no 179 0.0128599426659856 152 3960012 SGTC_1012 4112-3522 18 µM 2.23021198746286 0.0289819212277041 no 180 0.0128666864066103 163 3112398 SGTC_1301 naphtanilide LB 4.81 µM 2.22127780131655 0.029490371875191 no 181 0.0131660757226438 153 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_920 mycophenolic acid 780.421 nM 2.21230820471488 0.0300082648827251 no 182 0.0134726882918086 193 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_946 3434-1334 87.4 µM 2.2093839489754 0.0301787292139474 no 183 0.0135739732531453 163 4047976 SGTC_18 0111-0177 500 nM 2.20353049973477 0.0305223575370356 no 184 0.0137786898622749 263 721752 SGTC_1309 pyrazolanthrone 13.4 µM 2.19061037570397 0.0312923175465103 no 185 0.0142399998347785 168 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1860 st056228 74.6 µM 2.19059616309842 0.0312931732937866 no 186 0.01424051452988 165 688679 SGTC_1653 st012112 65 µM 2.18368415803048 0.0317116475351119 no 187 0.0144927323302217 139 720429 SGTC_556 4058-0063 51.5 µM 2.18089275881923 0.0318819531963027 no 188 0.0145956747179118 159 6615692 SGTC_108 0509-0257 621.132 µM 2.18075917037583 0.0318901224474052 no 189 0.0146006169856465 235 536624 SGTC_2160 5660466 132.927 µM 2.17969940275899 0.0319549910390752 no 190 0.0146398754355459 159 2859134 SGTC_1038 k292-0204 154 µM 2.17832674147671 0.0320391738596346 no 191 0.0146908598227784 150 4454212 SGTC_1082 camptothecin 424.86 nM 2.16761062379437 0.0327026879959532 no 192 0.0150941623786768 202 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_277 nystatin 15.5 µM 2.16546051856268 0.0328371724324044 no 193 0.0151762178955013 185 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_765 1319-0117 244 µM 2.16039712182848 0.0331556785763867 no 194 0.0153709700375938 155 3487746 YGL099W LSG1 SGTC_513 4245-1575 41.7 µM 2.15948953607959 0.0332130371416318 no 195 0.0154061041334629 346 719745 SGTC_1759 st043059 70 µM 2.15887125019115 0.0332521590161009 no 196 0.0154300784351402 186 669426 SGTC_61 0978-8327 98.565 µM 2.15885735695346 0.0332530385428362 no 197 0.0154306175191546 188 6150059 YHR072W ERG7 SGTC_2102 5377816 72.7585 µM 2.15006967397375 0.0338132038386211 no 198 0.0157748519889168 177 1379702 SGTC_341 1486-1430 230 µM 2.14984313254229 0.033827746599442 no 199 0.0157838125518748 196 2054753 YPL210C SRP72 SGTC_1232 0279-0259 161 µM 2.14952808099978 0.0338479797944326 no 200 0.0157962812783854 185 1560000 SGTC_86 0417-1630 471.922 µM 2.14851036484673 0.0339134074480975 no 201 0.0158366169465199 358 3634867 SGTC_3204 9114183 49.47 µM 2.14683654194659 0.034021241570841 no 202 0.0159031485256 191 17027248 SGTC_3047 9092122 49.47 µM 2.14259513343294 0.0342957524164947 no 203 0.0160728111397676 179 17173831 SGTC_858 0438-0351 2.77 µM 2.14241490659833 0.0343074571940807 no 204 0.0160800547073211 193 2799119 SGTC_2498 4'-Methoxychalcone 54.63 µM 2.13932880448306 0.034508393110225 no 205 0.0162045242265036 181 641818 YHR062C RPP1 SGTC_2828 7998861 71.43 µM 2.13931531254057 0.0345092736878526 no 206 0.0162050701942847 135 2988188 SGTC_2322 7413319 38.22 µM 2.13795633929675 0.034598064314505 no 207 0.0162601434857184 378 1840400 SGTC_429 1112-0049 25.5 µM 2.13791153044622 0.0346009951629693 no 208 0.0162619621210252 208 2836170 SGTC_146 3448-8650 53.125 µM 2.13053797925057 0.0350860680859523 no 209 0.0165636118727323 371 2891488 YIL048W NEO1 SGTC_1122 capsaicin 818.572 nM 2.12865982654148 0.0352105110454998 no 210 0.0166412074331149 185 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_937 3122-0005 46.7 µM 2.12427133105985 0.0355026965679751 no 211 0.0168237307806324 213 759535 SGTC_710 3448-4187 58 µM 2.12209608483594 0.0356482594115722 no 212 0.0169148350595899 287 3946412 SGTC_3179 9107801 49.47 µM 2.1199190251182 0.0357944330378544 no 213 0.017006437336242 160 4818259 SGTC_880 0833-0487 87.2 µM 2.11846221259591 0.0358925213479269 no 214 0.0170679709419657 180 76075 SGTC_1010 4112-3296 15.2 µM 2.1164518172407 0.036028244332233 no 215 0.0171531995049784 192 704384 SGTC_692 k241-0027 77.8 µM 2.11326406477065 0.0362443128294599 no 216 0.0172890863169682 169 3600480 SGTC_1274 0865-0114 173 µM 2.10940909313693 0.0365070219192838 no 217 0.0174546426405497 189 870624 SGTC_3098 9119039 49.47 µM 2.0960785418565 0.0374275078041668 no 218 0.0180376120932226 200 17161528 SGTC_1194 1488-0194 225 µM 2.09578455067507 0.0374480198365701 no 219 0.0180506537255541 215 1391452 SGTC_1093 fluphenazine 7.97 µM 2.09434406116084 0.0375486568422769 no 220 0.0181146709905223 194 6602611 An atypical antipsychotic. SGTC_1614 st002383 48.6 µM 2.09030868530726 0.03783175688342 no 221 0.0182950397929866 182 1947235 SGTC_2445 5742597 35.57 µM 2.08528634183499 0.0381865277199594 no 222 0.0185216582277488 185 1774255 SGTC_2995 9067767 71.4286 µM 2.0783774686116 0.038678988675724 no 223 0.0188373031429448 169 11673567 SGTC_3258 9138477 49.47 µM 2.07138554736218 0.0391826247765678 no 224 0.0191613902139649 174 4970355 SGTC_291 SEC14.278 35.5 µM 2.06874354429544 0.0393743153797939 no 225 0.0192850793507064 178 1068044 SGTC_867 0518-0118 155 µM 2.06870337641632 0.0393772356392216 no 226 0.0192869650915021 201 6848158 SGTC_2829 7992743 58.44 µM 2.06845366195025 0.0393953941736696 no 227 0.0192986918239444 241 16462845 SGTC_3214 9129694 49.47 µM 2.06530946064349 0.0396246151091569 no 228 0.0194468644965878 211 17158655 SGTC_1440 4100-1550 40 µM 2.06492275129147 0.0396528820372924 no 229 0.0194651550113062 119 742806 SGTC_1568 digitonin 820 nM 2.05496934912011 0.0403860964979589 no 230 0.0199409826517287 227 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1340 1486-1359 257 µM 2.05077029271529 0.0406987029244146 no 231 0.0201446609318838 203 4309068 SGTC_2365 9042475 200 µM 2.05008931820501 0.0407495838800471 no 232 0.020177857789149 229 6464479 SGTC_2005 4024620 188 µM 2.04534913197524 0.0411051921980228 no 233 0.0204102250513645 198 236743 SGTC_3132 9126706 49.47 µM 2.04191018952659 0.0413647531143139 no 234 0.0205802204232122 181 850858 SGTC_1665 st014639 11.4 µM 2.04141306764737 0.0414023840176677 no 235 0.0206048933268425 229 981133 YIL048W NEO1 SGTC_385 1494-0393 12.4 µM 2.02489919653575 0.042668292729265 no 236 0.0214388580685824 221 3090647 SGTC_835 0312-0010 67.2 µM 2.01468342779982 0.0434669497744141 no 237 0.0219689148552858 179 1626196 SGTC_1101 ebselen 5.29 µM 2.00433528121172 0.0442882152928754 no 238 0.0225170784694792 216 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2362 9071156 126 µM 1.99842658102731 0.0447627315175277 no 239 0.0228352161270146 215 653133 SGTC_947 3447-0010 211 µM 1.99824769628314 0.0447771610037172 no 240 0.0228449064477216 195 748350 SGTC_2602 kawain 100 µM 1.98576719164945 0.0457931650737013 no 241 0.0235295901464457 260 5369129 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.98300256036739 0.0460207142317144 no 242 0.023683571773045 268 65057 A dermal irritant. YDR527W RBA50 SGTC_3173 9105693 49.47 µM 1.97680807049348 0.0465338636169926 no 243 0.0240316645526174 245 17096658 SGTC_2852 9023854 51.95 µM 1.97587910013762 0.0466112136640803 no 244 0.0240842359090156 217 19798528 SGTC_1873 rapamycin 2 nM 1.96925481223365 0.0471657754698384 no 245 0.024461918717831 301 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1850 st056238 17 µM 1.95943833048557 0.0479972893500707 no 246 0.0250307377177403 244 5393177 SGTC_932 2857-0803 154 µM 1.95233758371449 0.0486060459781534 no 247 0.0254490690539566 234 674898 SGTC_122 0236-0016 402.397 µM 1.94983206229043 0.0488223152632941 no 248 0.0255980693589454 289 6808838 SGTC_773 4358-1457 44.6 µM 1.94719990561825 0.0490503429206539 no 249 0.0257553865072779 287 1186886 SGTC_2618 avocadyne 43.43 µM 1.94655255795532 0.0491065537608358 no 250 0.0257942005256973 213 3015189 SGTC_1687 st020778 55.3625 µM 1.9463817324363 0.0491213955510847 no 251 0.0258044511332319 428 4259299 SGTC_2163 5671233 125 µM 1.94619547156353 0.0491375824900887 no 252 0.0258156318440208 257 701023 SGTC_2334 9017922 200 µM 1.94318036706057 0.0494002022589077 no 253 0.0259971846835686 205 3163164 SGTC_1701 st028638 40.4 µM 1.94222489993813 0.0494836581707542 no 254 0.0260549399861951 240 3490878 SGTC_420 mitomycin C 81.9 mM 1.93465985831252 0.0501484110730965 no 255 0.0265160246793909 247 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3201 9113999 49.47 µM 1.93356870039703 0.0502448777147756 no 256 0.0265830893441186 254 16649224 SGTC_3250 9135583 49.47 µM 1.93328447632919 0.0502700295455277 no 257 0.0266005815462315 183 7699353 SGTC_1446 4239-0190 62 µM 1.93068868884769 0.0505002030824732 no 258 0.0267607812790717 285 1340085 SGTC_722 3534-0461 190 µM 1.90496960242166 0.052826401939422 no 259 0.0283920112876198 263 658262 SGTC_441 propafenone 146 µM 1.90311036726171 0.0529978045411744 no 260 0.0285130727282834 186 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_580 1123-0028 41 µM 1.90227508184513 0.0530749528199066 no 261 0.0285676007769464 329 1677248 YPR107C YTH1 SGTC_2434 5670830 169.91 µM 1.90025161550402 0.0532622125317444 no 262 0.0287000538056941 278 1549830 SGTC_1735 st034310 56.75 µM 1.89849013991845 0.0534256526121271 no 263 0.0288157727174588 251 871153 SGTC_1836 st055642 81 µM 1.89684600615549 0.0535785633877706 no 264 0.0289241326764425 274 8571 SGTC_744 1594-0068 283 µM 1.89227143866296 0.0540058405967175 no 265 0.0292274121648445 304 668392 SGTC_1229 0139-0193 12.2 µM 1.89037993579738 0.0541832985062683 no 266 0.0293535824397054 266 3090752 SGTC_2461 5755302 26.15 µM 1.88815378826786 0.0543927430381525 no 267 0.029502653806731 291 2788904 SGTC_587 k089-0003 57 µM 1.88254313711765 0.0549234562048944 no 268 0.0298811543339812 133 9659696 SGTC_1696 st025591 34.7925 µM 1.88087410876853 0.055082117358992 no 269 0.0299945229955494 282 2787147 SGTC_844 0330-0132 15.3 µM 1.87907669001165 0.0552533882962155 no 270 0.0301170112260133 245 2828079 SGTC_653 0203-0016 55.2 µM 1.87629698497132 0.0555190864096703 no 271 0.0303072554146899 250 295302 SGTC_1434 4073-0095 163 µM 1.86900748618525 0.0562206449691665 no 272 0.0308108864304059 241 24133745 SGTC_2200 6600604 21.907 µM 1.8636256784515 0.0567430737142148 no 273 0.0311871445053574 296 2904777 SGTC_3255 9139072 49.47 µM 1.85731627729423 0.0573604078866222 no 274 0.031633084974975 246 17646060 SGTC_1119 parthenolide 318.541 nM 1.85398638945018 0.0576883397416365 no 275 0.0318705536124687 355 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2729 fluphenazine 10.66 µM 1.84866955172574 0.0582150032634986 no 276 0.0322527714462272 280 3372 An atypical antipsychotic. SGTC_1843 st055809 45.5 µM 1.84542258088876 0.0585384876444742 no 277 0.0324880454318229 243 16413835 SGTC_3244 9134489 49.47 µM 1.84477515589256 0.0586031567829604 no 278 0.0325351264327646 271 16584271 SGTC_1408 3909-7976 48.8 µM 1.84176192467645 0.0589048767313858 no 279 0.0327549908769695 304 24152374 SGTC_1844 rapamycin 4 nM 1.83667327591023 0.0594171774836504 no 280 0.0331290713537939 447 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_273 hydroxyurea 18.1 mM 1.83582688711202 0.0595027256294704 no 281 0.0331916317971468 329 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1966 st070145 16.1 µM 1.83561182467524 0.0595244782869812 no 282 0.0332075435352795 262 3748532 SGTC_2522 biochanin a 4.94 µM 1.8339256961766 0.0596952391234127 no 283 0.0333325123089853 243 5280373 A possible chelator. SGTC_2977 9011197 71.43 µM 1.82750918188438 0.0603485763748387 no 284 0.0338116234674578 208 2704722 SGTC_889 0919-1524 82.7 µM 1.82643005511809 0.0604590020277252 no 285 0.0338927540535182 256 3905452 SGTC_2345 9052315 157.45 µM 1.82622565866746 0.0604799354514255 no 286 0.0339081389494397 280 6469265 SGTC_708 3448-5400 146 µM 1.82509748921521 0.0605955798691579 no 287 0.0339931595123336 314 3462195 SGTC_1283 0922-0125 16.4 µM 1.82346261647579 0.0607634714196541 no 288 0.0341166770455729 281 3360884 SGTC_2970 9090938 41.86 µM 1.82129796616878 0.0609863273788864 no 289 0.0342807877231092 376 17217104 SGTC_562 3772-2733 112 µM 1.81875398795308 0.0612490521952575 no 290 0.0344744855154829 351 2876874 YIL048W NEO1 SGTC_1071 trifluoperazine 6.31 µM 1.81350611715332 0.0617938097829974 no 291 0.0348768979952391 302 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2437 5741531 144.16 µM 1.8088185986652 0.0622835910420655 no 292 0.0352395949410474 303 2262990 SGTC_2240 6690706 185.951 µM 1.8083360150632 0.0623341858139982 no 293 0.0352771098987506 236 805876 SGTC_3197 9113331 49.47 µM 1.79972070496389 0.0632428313944256 no 294 0.0359523750435888 307 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_3030 9087619 49.47 µM 1.79684702450957 0.0635481977779975 no 295 0.0361799543282754 274 25236973 SGTC_301 4119-0100 24.5 µM 1.79666207324896 0.0635678905163765 no 296 0.036194641733656 349 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1054 3429-0080 167 µM 1.79659437250553 0.0635751001595534 no 297 0.0362000192259153 316 1162877 SGTC_1490 4089-0339 670 nM 1.79496347363311 0.063748971540483 no 298 0.0363297598606815 197 742542 SGTC_1721 st082152 9.2685 µM 1.78283171059544 0.0650539813692233 no 299 0.0373068510640633 266 5296051 SGTC_3245 9134821 49.47 µM 1.77784522321691 0.0655963509968861 no 300 0.0377146393753758 308 17014901 SGTC_1781 st038725 66.3 µM 1.77080840037293 0.0663676880526336 no 301 0.0382962842777877 401 4270275 YIL048W NEO1 SGTC_1902 st060212 70.5 µM 1.75925403507023 0.0676494223886286 no 302 0.0392671850061646 299 688944 SGTC_1278 0874-0585 172 µM 1.75673051250205 0.0679318866610634 no 303 0.0394818770512937 285 766306 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.75598065337057 0.068015995571384 no 304 0.0395458560198453 351 442882 SGTC_1158 4092-0494 91.8 µM 1.75507220678042 0.0681180003287035 no 305 0.0396234788131416 304 1148199 SGTC_2951 9072950 58.06 µM 1.75378224861221 0.0682630458855603 no 306 0.0397339129427764 326 16488155 SGTC_730 1436-0052 41.2 µM 1.75161426774474 0.0685073548980701 no 307 0.0399200787694922 242 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1319 1306-0155 43.7 µM 1.74679413523348 0.0690529503716377 no 308 0.0403365271385666 353 3122360 SGTC_2149 5554786 194.827 µM 1.74552676382336 0.0691969598995011 no 309 0.0404466089384704 347 745063 YPR165W RHO1 SGTC_2966 9084041 48.03 µM 1.7442205146064 0.0693456290969663 no 310 0.0405603227333048 302 17741380 SGTC_261 5-fluorouridine 15.376 µM 1.74289548545522 0.0694966869576773 no 311 0.0406759363921502 302 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1842 st055362 61.2 µM 1.73703643580592 0.0701676778259892 no 312 0.0411903698885678 345 676032 SGTC_627 1391-0720 175 µM 1.73629361396112 0.0702531020918192 no 313 0.041255965910091 299 997839 SGTC_1981 st071826 47 µM 1.73597261952026 0.0702900410852211 no 314 0.0412843380076156 266 11838600 SGTC_919 tnp00227 403.569 nM 1.73524983108662 0.0703732718995899 no 315 0.0413482818288289 356 1269246 A methoxyflavone. YNL221C POP1 SGTC_7 0192-1582 4.227 µM 1.7307835669204 0.070889254666947 no 316 0.041745186954324 399 252616 SGTC_1793 st048256 72.231 µM 1.72476731013982 0.0715888944476373 no 317 0.0422847075855902 248 672022 SGTC_2164 5685496 200 µM 1.724154808667 0.0716604192965582 no 318 0.0423399499357391 302 759046 SGTC_290 2043-6722 48.1 µM 1.72290148977345 0.0718069464346103 no 319 0.0424531704512457 292 773758 YLR208W SEC13 SGTC_1396 3511-0007 98.6 µM 1.72184682164187 0.0719304270067249 no 320 0.0425486351584407 280 X1396 SGTC_604 1000-0114 314 µM 1.7201761950638 0.0721263571524446 no 321 0.0427002093806408 332 1572745 SGTC_2004 4023728 41.89 µM 1.71585142424258 0.0726354640231906 no 322 0.0430946196622029 350 360084 YDR527W RBA50 SGTC_2771 fluoxetine 41.05 µM 1.71575529683379 0.0726468112128703 no 323 0.0431034196062921 286 3386 A selective serotonin reuptake inhibitor. SGTC_1218 1348-1416 30.7 µM 1.708832010973 0.0734676333309408 no 324 0.0437410356678996 304 6787668 SGTC_149 3970-0822 46.1 µM 1.70710590661101 0.0736733800151881 no 325 0.0439011847360072 495 3114250 YBL034C STU1 SGTC_2140 5586273 200 µM 1.70384073358049 0.0740637835875129 no 326 0.0442054228692358 258 854421 SGTC_1621 st003705 32.4 µM 1.70350708297193 0.0741037656786128 no 327 0.0442366068163255 361 24207032 SGTC_2785 7756463 72.73 µM 1.70201485363368 0.0742827846170985 no 328 0.0443762919251109 322 2201551 SGTC_1126 isoteolin 1.0172 µM 1.69752200690842 0.0748237741942781 no 329 0.0447990070513951 330 133323 SGTC_1192 1488-0095 21.4 µM 1.69437541390238 0.0752044458124375 no 330 0.0450969841960457 313 915875 SGTC_2207 7258803 200 µM 1.6941632786941 0.0752301627468017 no 331 0.0451171303018162 268 3666799 SGTC_609 0986-0026 86.3 µM 1.69328575621079 0.0753366151353585 no 332 0.0452005440158963 363 2848610 SGTC_1043 0916-0009 19.3 µM 1.6879748421166 0.0759833347383553 no 333 0.0457080291873382 409 3101130 SGTC_700 3453-2283 142 µM 1.68612453028217 0.0762096406983889 no 334 0.0458859080677071 379 565664 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.68386363895364 0.076486859314886 no 335 0.0461040124429201 328 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2925 9010536 32.5 µM 1.68347018229045 0.0765351811718945 no 336 0.0461420534714646 414 2994177 SGTC_872 0588-0139 234 µM 1.66951883451739 0.0782636472384401 no 337 0.0475073004523138 359 2047100 SGTC_2030 5175110 200 µM 1.66548635779154 0.0787687145462551 no 338 0.0479078815581427 323 2831986 SGTC_1352 1496-0991 99 µM 1.65664800898552 0.0798843503838515 no 339 0.0487953300214772 331 3000039 SGTC_2418 pentamidine 31.67 µM 1.65619435923115 0.0799419338794173 no 340 0.0488412326024729 350 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_684 1140-0066 328 µM 1.65211324495012 0.0804613773515466 no 341 0.0492557336946167 388 6813534 SGTC_3338 9144300 39.5675 µM 1.65191103973596 0.0804871801386335 no 342 0.0492763436144239 346 4901274 SGTC_3128 9127691 49.47 µM 1.64770212729211 0.081025686793199 no 343 0.0497069056534248 300 41316314 SGTC_205 1486-1330 71.903 µM 1.64471400623194 0.0814096475591025 no 344 0.0500144015259045 270 4118834 SGTC_250 brefeldin a 552.239 µM 1.6366807727453 0.0824486863454215 no 345 0.0508485942467244 269 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3284 9108171 64.8615 µM 1.6289564396652 0.0834571568057342 no 346 0.0516611203767874 309 8687505 SGTC_1344 1488-0097 29.1 µM 1.6287498079279 0.0834842609024953 no 347 0.0516829969945042 344 747966 SGTC_2150 5556613 200 µM 1.62759462999283 0.0836359086573383 no 348 0.0518054342671408 376 743190 SGTC_3021 9087658 49.47 µM 1.62610759001824 0.0838314266852195 no 349 0.0519633848441347 272 25237042 SGTC_2024 5144227 134 µM 1.6255257275817 0.0839080241194182 no 350 0.052025293229845 403 3475211 SGTC_491 tetrandrine 80.3 µM 1.62517958104151 0.083953616409509 no 351 0.0520621499534791 277 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1094 duloxetine 25.4 µM 1.62515794044321 0.0839564673935515 no 352 0.0520644548731312 362 60834 A selective serotonin reuptake inhibitor. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.62200738265785 0.0843723055834418 no 353 0.0524008836960224 478 6708739 YPR165W RHO1 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.61944103416737 0.084712175387625 no 354 0.0526762019677221 435 91467 include heat shock SGTC_163 TUB2.036 7.546 µM 1.61836507511627 0.0848549731843379 no 355 0.052791971992497 552 15992207 YJR013W GPI14 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.61646125068459 0.0851080846519761 no 356 0.0529973123826563 445 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3027 9089541 49.47 µM 1.61414169458583 0.0854172313240673 no 357 0.0532483476692803 388 9943819 SGTC_2341 7987486 176.74 µM 1.61116087713608 0.0858157438090498 no 358 0.053572331246972 402 1258686 SGTC_1181 1222-0449 220 µM 1.61088593237323 0.085852571804604 no 359 0.0536022933539219 366 658318 SGTC_3355 9151058 44.0485 µM 1.60993963736569 0.0859794154961466 no 360 0.0537055173375091 341 17015728 SGTC_1703 st026983 48.3 µM 1.60958667614812 0.0860267631694145 no 361 0.0537440594297987 372 1104023 SGTC_711 k292-0785 179 µM 1.60223988691969 0.0870167258974892 no 362 0.0545512864488181 364 4146315 SGTC_419 nsc-638432 893 µM 1.59700658818946 0.0877270731533864 no 363 0.0551321193355829 376 368090 SGTC_1624 st003710 6.25 µM 1.59035490606055 0.0886361783806438 no 364 0.0558774143980685 437 24207033 SGTC_945 3381-0768 11.3 µM 1.59033623178349 0.0886387404901001 no 365 0.0558795179114194 385 1126236 YIL048W NEO1 SGTC_181 1447-1644 8.07 µM 1.59005902020969 0.0886767803853886 no 366 0.0559107510056687 373 534600 SGTC_1867 st057372 64 µM 1.5874151474544 0.0890401925576346 no 367 0.0562093254283279 360 688837 SGTC_1654 st012436 41.8 µM 1.58296029638982 0.0896550375130303 no 368 0.0567152570722807 324 4323132 SGTC_578 3460-0051 92 µM 1.58198761204217 0.0897897033192448 no 369 0.0568261992602249 426 2876744 SGTC_268 camptothecin 39.6153 µM 1.58114799225294 0.0899060675204283 no 370 0.0569221017853148 499 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2959 9079155 11 µM 1.58095270718636 0.0899331484370915 no 371 0.0569444257719885 327 16189457 SGTC_2736 butenafine 14.65 µM 1.57905492358583 0.0901966370176385 no 372 0.0571617298429191 427 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2472 5377652 49.4 µM 1.5772472108326 0.0904481529974758 no 373 0.057369326890016 438 1610903 SGTC_188 3229-0966 278.469 µM 1.56771989089102 0.0917823456464761 no 374 0.0584732587584183 461 5722370 SGTC_1291 0993-0025 5.79 µM 1.5675529632384 0.0918058512244007 no 375 0.0584927483388405 369 4353356 SGTC_1817 st052116 64.4 µM 1.56444414378059 0.0922444284881748 no 376 0.0588566503584148 372 4361398 SGTC_532 1548-0774 215 µM 1.55583663752945 0.0934668222487864 no 377 0.0598734717887354 408 5932993 SGTC_249 wiskostatin 11.211 µM 1.55028600074593 0.094261415567181 no 378 0.0605364429453227 371 2775510 A n-wasp and actin depolymerizer. SGTC_2497 7-hydroxyflavone 100 µM 1.54960595598009 0.0943591079704856 no 379 0.0606180612740923 361 5281894 SGTC_2050 5263056 171 µM 1.54907851400975 0.0944349294890236 no 380 0.0606814236124629 460 763468 YGL055W OLE1 SGTC_2741 miltefosine 3.04 µM 1.5437747375118 0.0951998633168456 no 381 0.0613214566753782 319 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2081 5214970 32.255 µM 1.53635317897836 0.0962778782735428 no 382 0.0622258917088275 382 2063512 SGTC_1984 st072354 53.1 µM 1.53275680846053 0.0968034831706716 no 383 0.0626678931351103 366 5762938 SGTC_3084 9116877 49.47 µM 1.53195884082993 0.0969203902003865 no 384 0.0627662959376403 326 27241325 SGTC_1782 st039423 80.636 µM 1.52647922904363 0.097725986990629 no 385 0.0634452797239525 379 2068169 SGTC_1364 1653-0028 37.6 µM 1.52415592610331 0.0980690303251623 no 386 0.0637348824409266 417 5718652 SGTC_1987 st072290 61.9 µM 1.52235761727669 0.0983351617017212 no 387 0.0639597491921353 417 54697379 SGTC_414 piperonyl butoxide 100 µM 1.51972546495573 0.0987256464892169 no 388 0.0642899943643008 370 5794 A potent inhibitor of cytochrome P450. SGTC_3137 9097352 49.47 µM 1.51912394257429 0.0988150425621249 no 389 0.064365650573543 448 44120435 SGTC_1011 4112-3381 17.4 µM 1.51868276972293 0.0988806457130972 no 390 0.0644211828565015 418 2877139 SGTC_2032 5185112 25.99 µM 1.51442996640569 0.0995146796002295 no 391 0.0649584118776637 379 5718189 SGTC_2713 st079149 53.4 µM 1.51391770413262 0.0995912508401733 no 392 0.0650233566352461 431 3103253 SGTC_456 gingerol 170 µM 1.51188327551379 0.0998957754176829 no 393 0.0652817796991386 403 442793 A herb. SGTC_2999 9069765 71.4286 µM 1.51121471980637 0.0999959968664462 no 394 0.065366876635085 431 2097066 SGTC_1877 wortmannin 25 µM 1.50715107721087 0.10060674678244 no 395 0.0658859685028401 489 312145 A covalent inhibitor of PI 3-kinase. SGTC_800 3448-7362 155 µM 1.50478018536436 0.100964337312601 no 396 0.0661902998277062 705 15991913 SGTC_2272 7805186 180 µM 1.50457369749519 0.100995524719459 no 397 0.066216856387377 383 2956062 YPR165W RHO1 SGTC_13 0199-0087 65 µM 1.50300460930748 0.101232745303334 no 398 0.0664189276953188 429 4589825 SGTC_3168 9103419 49.47 µM 1.5001689024694 0.101662487419389 no 399 0.0667853281981518 286 16649256 SGTC_1226 3909-7979 35.4 µM 1.4982142915398 0.101959474673877 no 400 0.0670387918386489 479 6615510 SGTC_1750 st081859 2.357 µM 1.49778594866839 0.102024642151522 no 401 0.0670944363404199 633 5291695 SGTC_2137 5261020 140 µM 1.49728815904306 0.102100413230802 no 402 0.0671591472894248 414 763655 SGTC_786 4544-0069 423 µM 1.49385226195562 0.102624525318454 no 403 0.067607119087295 446 748821 YLR208W SEC13 SGTC_2017 5132927 60.65 µM 1.48878356206366 0.103401271599091 no 404 0.06827218613015 440 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2134 5324836 1.464 µM 1.48844501934152 0.103453302761876 no 405 0.0683167857579588 346 699272 SGTC_756 0508-1999 28.3 µM 1.48795463143401 0.103528704946453 no 406 0.0683814293410866 409 6753853 SGTC_3324 9138759 60.749 µM 1.48151422596728 0.104522687316669 no 407 0.0692347984430592 422 45595710 SGTC_2232 chlorophetanol 41.5365 µM 1.47992095342888 0.104769648896848 no 408 0.0694471715535642 577 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_15 0266-0086 27.098 µM 1.47958848839255 0.104821235125079 no 409 0.0694915502327651 539 1712902 YIL048W NEO1 SGTC_517 1365-0151 113 µM 1.47617779815217 0.10535151002702 no 410 0.0699480840216147 423 768657 SGTC_3270 9137563 49.47 µM 1.47606961657766 0.105368361183796 no 411 0.0699626022055546 368 17015724 SGTC_1760 st045453 10.4495 µM 1.47430377307547 0.105643697654221 no 412 0.0701999098761633 519 3323419 YIL048W NEO1 SGTC_890 0929-0006 47.2 µM 1.4722550105638 0.1059637993078 no 413 0.0704760136605313 405 1378169 SGTC_34 0469-0683 81.75 µM 1.47207440503516 0.105992050960276 no 414 0.0705003931518239 408 3690923 SGTC_1411 3909-8223 150 µM 1.47122312891495 0.106125287156413 no 415 0.0706153921017046 440 X1411 SGTC_17 0960-0276 49.807 µM 1.47045258477684 0.106245991998251 no 416 0.0707196092235713 483 6821114 SGTC_2688 kanamycin b 96.69 µM 1.46890209501419 0.106489174860334 no 417 0.0709296731670639 977 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3341 9147222 25.867 µM 1.46676553256094 0.106824936938814 no 418 0.071219924473073 416 1939759 SGTC_2173 5763948 167 µM 1.46661224256813 0.106849055889068 no 419 0.0712407838760092 457 2867177 SGTC_1072 oxiconazole 14.9 nM 1.46536795652669 0.107044979710701 no 420 0.0714102774879863 479 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2213 7173844 200 µM 1.46354429436876 0.107332599399358 no 421 0.071659251292152 430 892728 SGTC_1307 1187-1599 12.2 µM 1.45775734504226 0.108248978618953 no 422 0.0724537196708925 432 1538471 SGTC_863 0466-0191 129 µM 1.45671732798445 0.108414263331462 no 423 0.0725972122877934 507 765160 YPR165W RHO1 SGTC_1933 st074711 15.9 µM 1.45493474894517 0.108697981917228 no 424 0.0728436633346759 491 17250958 SGTC_502 l-744,832 89.3 µM 1.44778758780385 0.109840899291609 no 425 0.0738382325708079 452 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2608 thymoquinone 42.66 µM 1.43753909403144 0.111494769097562 no 426 0.0752824364006474 401 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2929 9013348 24.6 µM 1.43588367715549 0.111763578081426 no 427 0.0755177219618362 454 2995952 SGTC_1513 0337-0559 19 µM 1.43424764699895 0.112029694158783 no 428 0.0757508022101877 396 775073 SGTC_31 0508-1974 57.237 µM 1.43380586699319 0.112101631553018 no 429 0.0758138351307895 468 6810525 SGTC_2059 5238311 157 µM 1.43214290411418 0.112372716747243 no 430 0.0760514639684127 442 703021 SGTC_2706 st078239 82.5 µM 1.43180344387541 0.112428110823371 no 431 0.0761000407032608 445 15434492 SGTC_1282 0886-0010 32.4 µM 1.43059832359857 0.112624923296921 no 432 0.0762726841042439 506 2836211 YNL267W PIK1 SGTC_1442 4112-3290 3 µM 1.42988783029712 0.112741071715214 no 433 0.076374607690561 473 704353 SGTC_2848 9016370 25.97 µM 1.42787755599862 0.113070166075195 no 434 0.0766635523631541 529 7894410 SGTC_978 1416-0512 87.4 µM 1.42653183105011 0.113290852298618 no 435 0.0768574427665406 520 6814003 SGTC_271 rotenone 740 µM 1.42133183718194 0.114146489406025 no 436 0.0776101560696954 501 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1459 k035-0031 35.7 µM 1.41696507069285 0.114868570021288 no 437 0.078246570000114 418 3877128 YMR208W ERG12 SGTC_2834 9001755 58.44 µM 1.41339773558681 0.115460864974215 no 438 0.0787694055213852 428 2989575 SGTC_1279 0874-0590 65.2 µM 1.41279118708066 0.115561787453468 no 439 0.0788585651377834 467 3523074 SGTC_2028 5153890 36.43 µM 1.40571454091674 0.116743890554016 no 440 0.0799044536725545 465 2830968 YPR165W RHO1 SGTC_2636 apigenin dimethyl ether 100 µM 1.40519697267803 0.116830681832522 no 441 0.0799813570591278 518 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2013 4024628 200 µM 1.40492651166778 0.11687605376644 no 442 0.0800215660316767 466 5230760 SGTC_1070 indatraline 8.81 µM 1.39783263888446 0.118070568359814 no 443 0.0810816653009587 500 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2467 5474540 200 µM 1.39765989924912 0.118099762734415 no 444 0.0811076108380682 482 5413519 SGTC_2720 fluspirilene 36.88 µM 1.39708087071442 0.118197660408037 no 445 0.0811946267713251 418 3396 An atypical antipsychotic. SGTC_2104 5389443 200 µM 1.39708015358941 0.118197781689565 no 446 0.0811947345839392 541 2244536 SGTC_680 0417-1641 114 µM 1.39456640522012 0.118623452452242 no 447 0.0815733158272004 438 2835990 SGTC_2026 5148700 152 µM 1.39239099616456 0.118992703195279 no 448 0.0819020147505618 496 79838 SGTC_543 3844-1095 191 µM 1.39160516774647 0.119126287895685 no 449 0.082020996561461 515 4230703 SGTC_1674 st016616 23.6 µM 1.38783153388518 0.119769251023875 no 450 0.0825941750561304 483 625830 SGTC_14 0354-0009 295 µM 1.38741128754118 0.119841005006709 no 451 0.0826581925223965 502 1713507 SGTC_1791 st048313 56.1 µM 1.38399306178484 0.120425767981543 no 452 0.0831802896125693 427 1204976 SGTC_2470 5664817 21.68 µM 1.38233503832002 0.120710132142443 no 453 0.0834344261482872 456 2859561 SGTC_1772 st048439 82.2 µM 1.37907544713733 0.121270555187354 no 454 0.0839357465629102 518 2927068 YDL195W SEC31 SGTC_1963 st076565 50.3 µM 1.37645013979963 0.121723253927565 no 455 0.0843411569341465 492 4914280 SGTC_338 4055-0136 114 µM 1.37582831701965 0.121830652568046 no 456 0.0844373961598062 495 2900563 SGTC_23 0213-0011 39.996 µM 1.37526293557966 0.121928360662227 no 457 0.084524971478839 491 627608 SGTC_2664 lyso-paf C-16 73.48 µM 1.37334878451238 0.122259569015135 no 458 0.0848219716753379 512 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2128 5255449 168.493 µM 1.36929895416377 0.122962397480259 no 459 0.0854529223953251 528 736008 SGTC_1733 st037357 54.9 µM 1.36763419044786 0.123252129139991 no 460 0.0857133043651903 529 1272339 YGL099W LSG1 SGTC_1668 st014914 51.6 µM 1.36640001789454 0.123467230255131 no 461 0.0859067215949121 458 2839556 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.36387306643217 0.123908466881858 no 462 0.086303759480881 576 688788 SGTC_2528 xanthyletin 44.79 µM 1.3628229644216 0.124092151758446 no 463 0.0864691559098399 471 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2555 cholic acid 100 µM 1.36048756327357 0.124501345210984 no 464 0.0868378429244881 493 6708657 Influences liver metabolism. SGTC_506 n9-isopropylolomoucine 153 µM 1.35978987686298 0.124623771988418 no 465 0.0869482133870116 482 6610355 SGTC_672 1441-0018 53.7 µM 1.35973823337449 0.124632837492221 no 466 0.0869563872893866 469 251141 SGTC_2674 ligustilide 100 µM 1.35350739955548 0.125729983113162 no 467 0.0879467938591676 452 5319022 A signalling regulator. SGTC_5 0352-0601 109.883 µM 1.35191551564843 0.126011364549076 no 468 0.0882011717324755 445 762456 SGTC_2932 9016711 44.54 µM 1.35088957761458 0.126192941884596 no 469 0.0883654036745414 566 7117328 SGTC_995 3931-2021 34.6 µM 1.35014825862718 0.126324258894607 no 470 0.0884842156049908 490 730143 SGTC_2481 5478948 45.16 µM 1.34919777918501 0.126492765794036 no 471 0.0886367239631276 509 77792 SGTC_292 k038-0015 474 µM 1.34873197616639 0.126575403394283 no 472 0.0887115354313367 481 46368540 SGTC_2968 9090663 33.37 µM 1.34787328941263 0.126727840603527 no 473 0.088849570212218 512 25236811 SGTC_2120 5538279 151.968 µM 1.34532953776663 0.127180166780392 no 474 0.0892594194169895 503 2058197 SGTC_962 1254-0300 21.5 µM 1.34254439307753 0.127676703989307 no 475 0.0897097732403064 516 7340576 SGTC_1899 st063254 59.6 µM 1.34066709704646 0.128012148742705 no 476 0.0900142809286245 446 3093813 SGTC_1433 4060-0023 7.6 µM 1.33725161896034 0.128624012837757 no 477 0.0905702588196404 532 3840627 SGTC_3160 9100216 49.47 µM 1.33401486194205 0.129205730221761 no 478 0.0910994929475281 517 17191039 SGTC_2082 5219693 150 µM 1.33275921935577 0.129431887406701 no 479 0.0913054162454522 532 2834649 SGTC_1481 3346-2004 36 µM 1.33155954469158 0.129648220148285 no 480 0.0915024830714614 525 2770522 SGTC_594 1487-1584 10.8 µM 1.32458253844635 0.130911320041634 no 481 0.0926548252985447 537 5013332 SGTC_306 1672-3436 11.6 µM 1.32427400884585 0.130967371138118 no 482 0.0927060296302585 545 6797378 SGTC_2244 6635614 200 µM 1.32418625521804 0.130983316517261 no 483 0.0927205972603442 385 836499 SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.32237661372695 0.131312438687365 no 484 0.0930213861710197 578 1273210 SGTC_2060 5238662 140 µM 1.32092204702232 0.131577396531654 no 485 0.0932636788455079 511 790130 SGTC_1464 k208-0027 110 µM 1.32069942233492 0.131617981459157 no 486 0.093300803389254 558 X1464 SGTC_1178 0988-0033 191 µM 1.31891005110396 0.131944501220378 no 487 0.0935995927552953 561 5392207 SGTC_3166 9102297 49.47 µM 1.31695996033732 0.132300984414128 no 488 0.0939260230525933 562 25237072 SGTC_3354 9151612 71.43 µM 1.31613076006127 0.132452766007333 no 489 0.0940650791400379 570 27261949 SGTC_1198 1612-1005 86.7 µM 1.30983600789551 0.133608906539224 no 490 0.0951256595081668 556 6998509 SGTC_1774 st048371 48.465 µM 1.30558492894237 0.134393605456775 no 491 0.0958468741317891 568 4242727 SGTC_43 0570-0105 72.5 µM 1.30518634806439 0.134467340698094 no 492 0.095914700841948 635 1114046 YDL195W SEC31 SGTC_2576 guaiol 23.12 µM 1.30160887215806 0.135130397191974 no 493 0.0965250626755017 581 227829 SGTC_3094 9117742 49.47 µM 1.2966523595425 0.136052746413314 no 494 0.0973754140645913 583 17149698 SGTC_2876 9059903 25.97 µM 1.29655141648293 0.136071575409286 no 495 0.0973927890200933 571 6916095 SGTC_525 k781-2675 26.7 µM 1.29205383251176 0.136912324216346 no 496 0.0981692512735617 588 3651118 YDL195W SEC31 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.28964278777861 0.137364487822734 no 497 0.0985873561827947 536 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1559 coumarin 343 70.1 µM 1.28808076781424 0.137657970362436 no 498 0.0988589246542536 497 108770 A hepatotoxic, DNA x-linker. SGTC_691 1548-0686 185 µM 1.28587223147773 0.138073654447639 no 499 0.099243828144735 575 46495133 SGTC_1681 tripelennamine 100 µM 1.28176304549682 0.138849349184486 no 500 0.0999628906503865 488 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_81 0411-0046 9.971 µM 1.2816515382451 0.138870439784169 no 501 0.0999824560817408 515 12925265 SGTC_1960 st011366 51.8 µM 1.28083054724686 0.139025790048489 no 502 0.100126595977315 544 3972846 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.28064906759077 0.139060146107839 no 503 0.100158478494225 569 5377381 SGTC_2739 tacrine 100.86 µM 1.27772298487675 0.139614883013735 no 504 0.100673558942526 524 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_72 0744-0168 198.391 µM 1.27771138178967 0.139617085758439 no 505 0.100675605280939 547 677577 SGTC_3114 9122766 49.47 µM 1.2774120280524 0.139673923619923 no 506 0.100728410258387 522 17176985 SGTC_2549 cedrol 20.94 µM 1.2757124655722 0.139996915290068 no 507 0.101028590196907 502 6708665 A sedative which affects the nervous system. SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.27502966157307 0.140126820901018 no 508 0.101149371760178 568 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2533 agelasine 13.65 µM 1.27488501355136 0.140154351150845 no 509 0.101174972127911 601 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2320 7373003 200 µM 1.27486613977274 0.140157943588749 no 510 0.10117831283064 539 5415828 SGTC_622 1348-1566 26.3 µM 1.27457666349655 0.140213050384466 no 511 0.101229560876576 629 7340407 SGTC_214 4373-3496 70 µM 1.27106440299659 0.140882842242347 no 512 0.101852868925315 736 3779166 SGTC_3305 9127027 53.8275 µM 1.26963351681807 0.14115633503932 no 513 0.102107602327279 556 41905295 SGTC_1539 benzyladenosine 56 µM 1.26804757351769 0.141459885081293 no 514 0.10239048098027 539 92208 A nucleotide analog. SGTC_3190 9110366 49.47 µM 1.26526366969136 0.141993794217103 no 515 0.102888412673695 484 17123768 SGTC_2477 5967686 25.23 µM 1.26459065432226 0.142123072518549 no 516 0.103009052477939 557 776118 SGTC_390 dec-rvkr-cmk 16.7 µM 1.26120051397679 0.142775489508987 no 517 0.103618306761168 601 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1726 st035556 14.5795 µM 1.25846925062076 0.143302578982383 no 518 0.104111050496806 618 5919439 SGTC_1548 st061468 90.8 µM 1.25646853450984 0.143689517543975 no 519 0.104473073591312 584 390799 SGTC_125 0133-0007 11.75 µM 1.25564075645475 0.143849815858204 no 520 0.104623123793013 606 26541 SGTC_2544 sphondin 68.51 µM 1.25531016652668 0.143913867934048 no 521 0.104683092979485 547 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1162 k048-0130 20.1 µM 1.25524338884539 0.143926808500945 no 522 0.104695209507655 581 6797406 SGTC_407 eburnamonine 100 µM 1.24997277394263 0.144950654937932 no 523 0.105654746565951 515 3195 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.24865549132624 0.145207308460113 no 524 0.105895553347617 670 551469 SGTC_1257 0669-0121 16 µM 1.24837099962374 0.145262777692957 no 525 0.105947612097931 647 4307855 SGTC_1403 3909-7815 62.9 µM 1.24539831788892 0.145843233896988 no 526 0.106492685659183 526 6615483 SGTC_2276 7947513 42.08 µM 1.24505292204384 0.145910778038524 no 527 0.10655614879402 543 2105100 SGTC_1147 3809-1045 12.3 µM 1.23762116192383 0.147369193884923 no 528 0.107928281995267 582 325925 SGTC_2982 9019404 25.97 µM 1.23708746952196 0.147474300846196 no 529 0.108027305601482 487 22333232 SGTC_1655 st012546 55.1 µM 1.23544484542033 0.147798119229786 no 530 0.108332495690206 545 720985 YLR208W SEC13 SGTC_2219 9098279 200 µM 1.23509782344742 0.147866590207551 no 531 0.108397049680666 558 902349 SGTC_3067 9117431 49.47 µM 1.23256934374599 0.148366126100195 no 532 0.108868240167315 543 17150885 SGTC_148 3253-0744 288.01 µM 1.2320822491333 0.148462487848628 no 533 0.108959180755702 574 6893655 SGTC_1805 st050013 60.3 µM 1.23003997485851 0.148866965757137 no 534 0.10934106790035 562 4037144 SGTC_2482 5981709 142.65 µM 1.22959976811275 0.14895424626277 no 535 0.109423508456824 624 877755 SGTC_2553 4-methylesculetin 85.09 µM 1.22941773723952 0.148990347809126 no 536 0.109457611679515 601 5319502 SGTC_382 3229-0966 23.2 µM 1.22862339840092 0.149147954657786 no 537 0.10960651925597 634 5722370 SGTC_78 0336-0123 156.75 µM 1.22613225409756 0.149642951062125 no 538 0.110074454948355 550 6765896 SGTC_2235 salicylic acid 500 µM 1.22511812600221 0.149844774357511 no 539 0.110265358328706 572 338 A COX inhibitor and kinase inhibitor. SGTC_2692 st077426 47.7 µM 1.22295483382048 0.150275901119543 no 540 0.110673378009474 615 25238571 SGTC_2349 9023730 187.07 µM 1.22213002995725 0.150440495365409 no 541 0.110829229270656 582 4126287 SGTC_734 2023-0417 80 µM 1.2221093871745 0.150444616288676 no 542 0.110833131854783 598 3935732 SGTC_104 0074-0074 590.992 µM 1.22054082579354 0.150757968510113 no 543 0.111129961434882 455 3943124 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.21939215573147 0.150987714288141 no 544 0.111347692892732 639 6728940 SGTC_658 3253-0951 102 µM 1.21937205783347 0.150991736146607 no 545 0.111351505183799 716 1184878 SGTC_1956 st077085 54 µM 1.21804883853555 0.151256686917949 no 546 0.111602707042129 640 24208685 SGTC_2732 terfenadine 20 µM 1.2179172973452 0.151283042555183 no 547 0.111627701150388 538 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_642 0335-0876 158 µM 1.21315060322267 0.152240159889034 no 548 0.112536122955913 614 6812350 SGTC_1193 1488-0126 41.5 µM 1.21250254304366 0.152370595399898 no 549 0.112660034863157 615 1384710 SGTC_1458 k015-0034 6.33 µM 1.21247690475442 0.152375757160581 no 550 0.112664939017686 569 3598957 SGTC_226 1,3-diallylurea 8.28947 mM 1.20970203933313 0.152935107317937 no 551 0.113196623529252 551 74537 YKL182W FAS1 SGTC_843 0310-0051 143 µM 1.20665531231675 0.153550824680946 no 552 0.113782457821737 626 2065037 SGTC_121 0557-0495 61.343 µM 1.20653733796668 0.15357469925128 no 553 0.113805185678668 776 3104427 SGTC_641 4092-0595 30 µM 1.20289160881076 0.154313700297748 no 554 0.114509133969377 645 786260 SGTC_1683 st010134 710 nM 1.2025024207798 0.154392728645603 no 555 0.114584464387459 630 3818134 SGTC_2658 polymyxin b sulfate 77.05 µM 1.2017784158342 0.154539815945953 no 556 0.114724695085165 649 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_837 0091-0265 12.5 µM 1.20036017941274 0.154828210162015 no 557 0.114999743516759 653 759367 SGTC_3206 9114350 49.47 µM 1.19734077309885 0.155443381019205 no 558 0.115586879180555 585 17087243 SGTC_1314 1222-0010 41.1 µM 1.19556440213647 0.155806049549737 no 559 0.115933295020607 611 3526027 SGTC_1695 st026914 34.495 µM 1.19409526410187 0.156106413776674 no 560 0.116220352788386 620 3289191 SGTC_1820 st053765 18.6 µM 1.19122018198239 0.156695325571565 no 561 0.116783579316519 599 3690829 SGTC_55 0767-0285 6.563 µM 1.19078343249452 0.156784914068655 no 562 0.116869307239429 664 3116166 SGTC_1002 4049-0206 172 µM 1.18891793635568 0.157167954469179 no 563 0.117235980636043 682 4662749 SGTC_1421 4029-0249 71.4 µM 1.18887572702388 0.157176628381189 no 564 0.11724428652651 691 2894095 SGTC_1729 st035615 45.989 µM 1.18878780985067 0.157194696150825 no 565 0.11726158807729 612 17385451 SGTC_870 0573-2213 57.6 µM 1.18669362729494 0.157625473190752 no 566 0.117674244814496 612 3916321 SGTC_2384 9036245 200 µM 1.18262458210496 0.158464698446985 no 567 0.118478982849247 646 6462766 SGTC_1698 5-fluorocytosine 1.055 µM 1.18002810206585 0.159001741637335 no 568 0.118994519083383 632 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3040 9091894 49.47 µM 1.18001585691065 0.159004277187226 no 569 0.118996954129987 559 25236966 SGTC_791 1348-1292 225 µM 1.17999831934096 0.159007908660016 no 570 0.119000441676631 723 5437054 SGTC_1876 myriocin 605 nM 1.17836018567366 0.159347353637782 no 571 0.119326521601861 639 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_231 b-estradiol 524 µM 1.17810197868584 0.159400901115627 no 572 0.11937797665994 559 450 A steroid. SGTC_25 0118-0223 35.662 µM 1.17607293332673 0.159822098564297 no 573 0.11978286640206 624 5333628 SGTC_1343 1487-0095 224 µM 1.1758865926272 0.159860816390097 no 574 0.119820098602197 614 4560101 YGL055W OLE1 SGTC_2626 ethyl orsellinate 100 µM 1.17442424795626 0.160164875000867 no 575 0.120112568788815 602 75653 A natural product. SGTC_79 0052-0007 94.094 µM 1.17388366010305 0.1602773726021 no 576 0.120220814081682 655 2801472 SGTC_2363 9053361 176 µM 1.17336254621508 0.160385866501058 no 577 0.120325225024868 653 6469797 YMR079W SEC14 SGTC_155 k072-0202 43.6 µM 1.16924399268586 0.161245021464386 no 578 0.12115267061313 618 5857737 SGTC_706 4262-0057 46.9 µM 1.16847886924247 0.161404960878469 no 579 0.121306828934944 625 883298 SGTC_2695 st077686 51.995 µM 1.16677698004961 0.161761090236838 no 580 0.121650222849921 612 2876092 SGTC_905 2-aminofluorene 215 µM 1.16388027726682 0.162368417292226 no 581 0.122236266680654 699 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1244 0416-0015 52.5 µM 1.16233618065239 0.16269276054857 no 582 0.122549467765684 629 96201 SGTC_2040 5100729 123 µM 1.16143360655161 0.162882544644116 no 583 0.122732804404379 665 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_3198 9112019 49.47 µM 1.16109322223243 0.162954154560101 no 584 0.122801995379685 623 45595555 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.1601937783005 0.163143477698153 no 585 0.12298495976719 652 229346 A bile salt which induces apoptosis. SGTC_405 ebelactone b 50 µM 1.15584124239515 0.164061657762544 no 586 0.123873050025265 679 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_3063 1327-0034 4 µM 1.15556991767036 0.164119005283981 no 587 0.123928559300269 628 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1669 st015249 58.4 µM 1.15460529610049 0.164322994135205 no 588 0.124126048452776 652 722793 SGTC_1173 0443-0020 122 µM 1.1513323792497 0.16501634352389 no 589 0.124797760611182 652 5331295 SGTC_263 alizarin 107.927 µM 1.1496202382381 0.165379804687188 no 590 0.125150159435459 741 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_527 4476-4215 268 µM 1.146142157262 0.166119741231566 no 591 0.125868168347899 673 4418754 SGTC_600 1495-0418 41.6 µM 1.14531700776335 0.166295599226695 no 592 0.126038931567789 632 5377768 SGTC_611 3453-1652 23.7 µM 1.1419118242678 0.167022592035061 no 593 0.126745336588293 703 1560575 SGTC_285 1486-1325 46 µM 1.14052394262655 0.167319486130611 no 594 0.127034041825417 708 22310230 SGTC_1341 1486-1360 280 µM 1.14031371220391 0.16736448803315 no 595 0.127077813551959 659 3976547 SGTC_1397 3532-0190 20.1 µM 1.13983956814932 0.167466011890923 no 596 0.127176572823167 582 5322280 SGTC_370 0180-0345 38.7 µM 1.13421105538658 0.1686742208694 no 597 0.128353013868666 609 3989527 SGTC_1900 st060200 72.8 µM 1.13351340238111 0.168824367421332 no 598 0.128499358093038 680 688945 SGTC_2304 7443016 91.4 µM 1.1318544598093 0.169181744281172 no 599 0.128847813661634 611 939854 SGTC_2404 5161160 200 µM 1.13179150040823 0.169195316838238 no 600 0.128861050979195 711 2831543 SGTC_3183 9108214 49.47 µM 1.13101672441912 0.169362397441484 no 601 0.129024026136867 558 4974831 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.12983156894035 0.169618181281779 no 602 0.129273601607768 754 688761 SGTC_141 0443-0274 32.331 µM 1.12797967190204 0.170018359176524 no 603 0.129664252137668 788 1627241 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.1277001174293 0.170078820853405 no 604 0.129723294029371 738 16486 A toxic proline analog. SGTC_2823 7987624 58.44 µM 1.12762882202468 0.17009424273563 no 605 0.129738354594739 700 2239440 SGTC_2489 cantharidin 73.42 µM 1.12722361154254 0.170181910683772 no 606 0.129823974960498 680 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1762 st045503 25.4615 µM 1.12579873698891 0.170490414471413 no 607 0.130125359452895 680 4645554 SGTC_3307 9126885 69.2785 µM 1.12517119611915 0.170626398717519 no 608 0.130258248170225 705 24824909 SGTC_2808 7946468 45.46 µM 1.1249685962954 0.170670315676216 no 609 0.13030117096594 714 2970879 SGTC_1678 st019265 80.2 µM 1.12463777484657 0.170742042406151 no 610 0.130371279825116 710 5367020 SGTC_136 0097-0015 404.482 µM 1.12193797149489 0.171328118680594 no 611 0.130944407173162 736 4861337 SGTC_2773 thioridazine 9.09 µM 1.11710011427768 0.172381538840747 no 612 0.131975760829781 704 5452 An antipsychotic. SGTC_2058 5236698 133 µM 1.11656036621454 0.17249932204999 no 613 0.132091172913244 671 766665 SGTC_3054 9094397 49.47 µM 1.11234392291995 0.173421195380018 no 614 0.132995152776757 714 2598354 SGTC_1286 0929-0070 131 µM 1.10600197011116 0.174813679102449 no 615 0.134362833325686 726 1420408 SGTC_1931 st074438 57.1 µM 1.10578360077642 0.17486175185543 no 616 0.134410097371048 661 2787313 SGTC_3211 9128781 49.47 µM 1.10465419456664 0.17511051802969 no 617 0.134654729206576 666 17194361 SGTC_2479 5617353 43.85 µM 1.10439698525351 0.175167203042731 no 618 0.134710483993983 705 2731746 SGTC_1985 st071382 65.5 µM 1.10313669034975 0.175445121032659 no 619 0.134983904763328 702 6123237 SGTC_462 ag-879 158 µM 1.09950872278233 0.176246713356636 no 620 0.135773115677321 743 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_3345 9148410 3.559 µM 1.09565715867518 0.177100241037823 no 621 0.13661441881474 692 4903596 SGTC_855 0428-0020 25 µM 1.09515932218278 0.177210754588113 no 622 0.136723421613311 658 6812414 SGTC_922 1866-0035 480 µM 1.09269605803782 0.177758209509571 no 623 0.137263635559914 816 3156169 SGTC_458 nppb 133 µM 1.09203334482637 0.177905677977946 no 624 0.137409222507283 686 4549 A chloride channel blocker. SGTC_1764 st044502 93.5 µM 1.09158863231702 0.178004679675549 no 625 0.137506977461292 708 8407 SGTC_323 4013-0906 34.3 µM 1.09013829855414 0.178327793644586 no 626 0.137826113965317 710 2910086 SGTC_801 0866-0028 10.1 µM 1.08608142890057 0.179233568318108 no 627 0.138721483919155 757 6849771 SGTC_2687 chenodiol 100 µM 1.08459944265363 0.179565170727764 no 628 0.139049550992067 681 5702181 A cholesterol synthesis inhibitor. SGTC_878 0828-0289 13.7 µM 1.08346451099467 0.179819378337417 no 629 0.139301147470623 746 745350 YLR208W SEC13 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.08219100421971 0.180104893691025 no 630 0.139583832446024 663 2374 Ca(2+)-ATPase inhibitor. SGTC_1042 0350-0096 82 µM 1.08209243948989 0.180127003386353 no 631 0.139605727474518 684 3122515 SGTC_3186 9110464 49.47 µM 1.08174506597329 0.180204938581332 no 632 0.139682911151116 711 17018021 SGTC_668 1682-0499 62.6 µM 1.08155115889497 0.180248451923956 no 633 0.139726008402155 760 682214 SGTC_2775 cyproheptadine 69.59 µM 1.08050951824276 0.180482312116989 no 634 0.139957675282044 735 2913 A selective serotonin reuptake inhibitor. SGTC_2144 5628481 200 µM 1.07865538986195 0.180899055728709 no 635 0.140370689633643 683 2818399 SGTC_1977 st070720 65.3 µM 1.07848303685491 0.180937825306595 no 636 0.140409123939141 675 682188 SGTC_981 1488-1094 54.9 µM 1.07847022971049 0.180940706390079 no 637 0.140411980186683 661 3449522 SGTC_2673 kobusone 100 µM 1.07697410869323 0.181277470234266 no 638 0.140745916399123 742 6710676 An epoxy ketone and protein crosslinker. SGTC_1610 st001799 48.1 µM 1.07691188607348 0.181291484501777 no 639 0.140759816233881 659 621897 SGTC_2868 9035608 32.47 µM 1.07268864647186 0.182244261082216 no 640 0.141705418049353 718 6462614 SGTC_1972 st070201 17.4 µM 1.07055990183038 0.182725696827795 no 641 0.14218368063169 741 2829099 SGTC_1865 st057639 52.2 µM 1.06739990238724 0.183441823251344 no 642 0.142895646263971 735 688818 SGTC_3116 9124943 49.47 µM 1.06637144004169 0.183675272643867 no 643 0.143127883415062 671 41905195 YPL160W CDC60 SGTC_2539 epi(13)torulosol 80 µM 1.06512407988315 0.18395865765459 no 644 0.143409891870878 693 6708597 SGTC_2172 5754775 163.918 µM 1.06047382604417 0.185017536187377 no 645 0.144464545694108 664 2263357 SGTC_963 1269-2853 151 µM 1.05951611612796 0.185236079306857 no 646 0.144682396779061 688 3668223 SGTC_2488 5268135 45.7 µM 1.05751137546876 0.18569406670505 no 647 0.145139132894541 815 1270356 YLR208W SEC13 SGTC_1075 aripiprazole 15.2 µM 1.05390365840036 0.186520025395876 no 648 0.145963513900162 795 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1164 k060-0068 93.7 µM 1.05280980220068 0.186770904057204 no 649 0.146214085774136 789 5963676 SGTC_1980 st071811 45.7 µM 1.05239873044711 0.186865238364005 no 650 0.146308325459287 750 4974850 SGTC_247 mechlorethamine 29.705 µM 1.05067434062826 0.187261279068159 no 651 0.14670409238866 701 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3312 9133330 71.43 µM 1.04764325437706 0.187958685605325 no 652 0.147401500487567 805 17617324 SGTC_3118 9124250 49.47 µM 1.04684697089799 0.188142163869964 no 653 0.147585081408868 684 1504786 SGTC_1056 3448-1962 115 µM 1.0463165014018 0.188264455058773 no 654 0.14770746462762 724 715507 SGTC_1917 st066507 28.5 µM 1.04495704866192 0.188578078788484 no 655 0.148021410579064 772 3156428 SGTC_2529 gangaleoidin 93.61 µM 1.04414574511483 0.188765398705426 no 656 0.148208982046121 770 4565183 SGTC_1949 st076024 69.1 µM 1.04350085379965 0.188914377880558 no 657 0.148358192794777 725 2921930 SGTC_2790 5423970 71.43 µM 1.04289223803404 0.189055043306228 no 658 0.14849910247133 795 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_3351 9150312 21.596 µM 1.04025839990412 0.189664528639699 no 659 0.149109932872681 753 4904905 SGTC_3309 9129340 25.759 µM 1.03895074665974 0.18996757562497 no 660 0.149413821729304 820 17158987 SGTC_1362 1611-0397 101 µM 1.03877558919324 0.190008190739345 no 661 0.149454558392556 756 27816 SGTC_2390 9097792 176.6 µM 1.03815060189935 0.190153154863865 no 662 0.149599973140109 723 4497149 SGTC_1666 st014829 29 µM 1.03784637631775 0.190223743755459 no 663 0.14967079094895 791 3858230 SGTC_2496 diffractaic acid 79.83 µM 1.03678660096178 0.190469767141218 no 664 0.149917660720738 806 94870 An apoptosis inducer which activates caspases. SGTC_1606 st000094 49.2 µM 1.03665443679142 0.190500462318046 no 665 0.149948466786607 825 1242210 SGTC_1495 4469-0029 237 µM 1.03364965264721 0.191199143801049 no 666 0.150649989044505 868 793680 SGTC_2183 6420625 130.508 µM 1.03348854107329 0.191236650272736 no 667 0.150687665148927 819 2897619 SGTC_2335 9018011 154.17 µM 1.0322767405177 0.191518899683611 no 668 0.150971246998085 805 6458208 SGTC_803 4488-1585 147 µM 1.03070345069833 0.191885726764565 no 669 0.151339953041803 778 747204 SGTC_337 1315-0038 354 µM 1.03014120993219 0.192016922649357 no 670 0.151471861283981 778 1626437 SGTC_3261 9137475 49.47 µM 1.03009056526165 0.192028743007653 no 671 0.151483746866348 565 17027690 SGTC_2994 9053520 71.4286 µM 1.0297390556658 0.192110796869423 no 672 0.151566258246024 774 4647384 SGTC_3122 9126309 49.47 µM 1.02955146165481 0.192154596238772 no 673 0.151610305230766 787 17591206 SGTC_1369 1866-0067 208 µM 1.02668006045116 0.192825771949257 no 674 0.152285570693174 841 3531355 SGTC_3015 9080845 49.47 µM 1.02562842672519 0.193071943963162 no 675 0.15253338144735 831 5296973 SGTC_225 nsc-122657 1.016 µM 1.02542439335165 0.193119727396534 no 676 0.152581491581027 642 275685 SGTC_596 1155-0152 116 µM 1.02484715971991 0.193254951267871 no 677 0.152717655150477 805 280313 SGTC_2907 7721985 69.9 µM 1.02231722132855 0.193848300930578 no 678 0.153315392509985 756 3267881 SGTC_636 0kpi-0074 126 µM 1.02209550030186 0.19390035431303 no 679 0.153367851330985 746 616434 SGTC_3100 9120536 49.47 µM 1.02112073925054 0.194129299721627 no 680 0.153598619188342 667 16421196 SGTC_582 0987-0078 156 µM 1.02000585199111 0.194391358825424 no 681 0.153862842682801 889 1625765 SGTC_2357 9067248 200 µM 1.01901322702978 0.194624860785432 no 682 0.15409834353405 727 9150235 SGTC_2313 7726885 200 µM 1.0166518675473 0.19518102505024 no 683 0.154659535320293 750 726423 SGTC_1437 4092-1038 11.6 µM 1.01636144697833 0.195249493617185 no 684 0.154728648723831 827 3977136 SGTC_1304 1165-0502 251 µM 1.01623213006656 0.195279985628663 no 685 0.154759429734332 813 767425 SGTC_3028 9087778 49.47 µM 1.01547657754157 0.195458197390627 no 686 0.154939353050037 798 17217395 SGTC_1263 0774-1208 64.8 µM 1.01430481620368 0.195734775408443 no 687 0.155218663313117 857 906585 SGTC_3269 9137823 49.47 µM 1.0133058993911 0.195970743348696 no 688 0.155457035275471 713 17682936 SGTC_2719 novobiocin 32.65 µM 1.00862509558935 0.197078757905932 no 689 0.156577233567465 749 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.0073052582842 0.197391866565457 no 690 0.156894051835747 777 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3091 9116372 49.47 µM 1.00583305562058 0.19774147599169 no 691 0.15724794168451 747 17169793 SGTC_2234 tolnaftate 200 µM 1.00128905588049 0.198822913945802 no 692 0.158343541183204 774 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2400 5203494 178.7 µM 1.00052093224797 0.199006073274483 no 693 0.158529236409836 732 6777674 SGTC_2257 7960413 200 µM 0.999309883724595 0.199295054622132 no 694 0.158822299487161 852 2974689 YIL048W NEO1 SGTC_1144 3486-0183 12.5 µM 0.998416794271731 0.199508326130663 no 695 0.159038646623158 838 6744069 SGTC_391 gliotoxin 8.33 µM 0.997982849741954 0.199612002504329 no 696 0.159143837517282 852 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.997946080599625 0.199620788737403 no 697 0.159152752683533 875 368090 SGTC_1615 st002656 86.5 µM 0.99678838142484 0.19989754771904 no 698 0.159433619505599 803 1584458 SGTC_3052 9092717 49.47 µM 0.995168044595059 0.200285291889791 no 699 0.159827270411831 769 25237534 SGTC_289 k017-0060 526 µM 0.994840461906587 0.200363736816464 no 700 0.159906931818965 770 5512909 SGTC_2767 sibutramine 71.45 µM 0.994259047818486 0.200503011184582 no 701 0.160048383768247 835 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_305 1682-2595 20.8 µM 0.993478687887367 0.200690033232407 no 702 0.160238365718056 833 226033 SGTC_3272 9137413 49.47 µM 0.992067285571425 0.201028557567801 no 703 0.160582351870987 772 17614870 SGTC_516 3992-2719 87.3 µM 0.991869301279434 0.201076071407482 no 704 0.160630643035441 757 5350887 YDR037W KRS1 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.987641500286417 0.202092299432194 no 705 0.161664126988268 809 6312947 SGTC_2857 9024691 58.44 µM 0.984902998043591 0.202752184755183 no 706 0.162335860301711 770 16478292 SGTC_2450 5739737 12.93 µM 0.984562788544281 0.202834253412934 no 707 0.162419437742226 751 2262825 SGTC_586 0957-0265 8.15 µM 0.984433983320934 0.202865330245072 no 708 0.162451087936843 745 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2683 piperine 63.03 µM 0.984308548402406 0.202895596657275 no 709 0.162481913832933 795 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_731 3966-0296 387 µM 0.979536864980861 0.204048966346042 no 710 0.163657391385859 818 660956 SGTC_3080 9117754 49.47 µM 0.979115048709147 0.204151111656969 no 711 0.163761568414005 891 9550191 SGTC_166 k072-0058 166.424 µM 0.977169070696323 0.204622735960142 no 712 0.16424272871444 834 5846229 SGTC_899 1083-0020 478 µM 0.976178673719622 0.204863015786721 no 713 0.164487964806574 846 767123 SGTC_718 1130-0073 349 µM 0.974676404056894 0.205227800931227 no 714 0.164860400494258 839 6740020 SGTC_1633 st005664 67.9 µM 0.974589654285326 0.205248877522637 no 715 0.164881923760087 830 2063822 SGTC_3170 9103054 49.47 µM 0.973765067872002 0.205449281971124 no 716 0.165086600661141 769 16432970 SGTC_3301 9125354 19.7965 µM 0.970090463318711 0.206343756009066 no 717 0.166000701092171 753 41905162 SGTC_2241 6772625 37.8075 µM 0.969624959355335 0.20645723367812 no 718 0.166116733564645 781 2285411 SGTC_3313 9133968 57.047 µM 0.968692598517217 0.206684629978466 no 719 0.166349293272566 877 1494643 SGTC_2083 5306046 65.942 µM 0.968292784795514 0.206782187171594 no 720 0.166449083590346 817 539837 SGTC_1629 st005085 44.9 µM 0.965118167645739 0.207557781862434 no 721 0.167242814121106 814 24207091 SGTC_3169 9102970 49.47 µM 0.956692417795118 0.209624605804157 no 722 0.169361263136773 868 17027839 SGTC_1482 3346-2049 8.48 µM 0.955586765999479 0.209896716072613 no 723 0.169640525107148 834 3826804 SGTC_3321 9137793 26.8275 µM 0.953843540244999 0.210326160127035 no 724 0.170081423083068 852 4904192 SGTC_1806 st050005 60.3 µM 0.953175818819574 0.210490790001676 no 725 0.17025049804349 820 5194765 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.950551022735942 0.211138678486497 no 726 0.170916170633785 803 6708514 SGTC_545 4218-0007 221 µM 0.949592005904303 0.211375687483519 no 727 0.171159800991168 809 2840508 SGTC_3048 9093155 49.47 µM 0.946194285789171 0.212216644519824 no 728 0.172024750073904 803 25236002 SGTC_2935 9038016 29.96 µM 0.944239538321438 0.212701341729256 no 729 0.172523627404955 896 6463195 SGTC_749 1000-0129 128 µM 0.944027726790102 0.21275390108954 no 730 0.172577739849322 909 708470 SGTC_3135 9127742 49.47 µM 0.944009730720887 0.212758367021572 no 731 0.172582337884807 805 3643468 SGTC_2708 st078559 56 µM 0.943257356969828 0.212945126209665 no 732 0.172774640940276 777 17250902 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.942296957867964 0.213183661769186 no 733 0.173020312619553 855 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2132 5317594 122.667 µM 0.940313165367938 0.213676871964758 no 734 0.173528474233306 810 794577 SGTC_2973 9094665 17.96 µM 0.939871136367881 0.213786859636636 no 735 0.17364183216284 915 25237061 YIL048W NEO1 SGTC_1554 st069299 38.7 µM 0.939269572195519 0.2139365965342 no 736 0.173796178413061 850 24207999 SGTC_2238 6671620 73.2395 µM 0.937350712264066 0.214414632737574 no 737 0.174289092547759 856 729941 SGTC_2625 euphol 100 µM 0.935715073883836 0.214822601295631 no 738 0.174709953700972 886 6708538 A triterpene alcohol. SGTC_2112 5488546 200 µM 0.93512600454455 0.214969640098839 no 739 0.17486168323779 857 600757 SGTC_666 0272-0154 136 µM 0.935040925296514 0.214990881733432 no 740 0.174883604434951 869 6870312 SGTC_3129 9127257 49.47 µM 0.93416969896154 0.215208469912869 no 741 0.175108181678579 732 837894 SGTC_1738 st035555 74 µM 0.933916348854423 0.215271767908907 no 742 0.175173522412335 867 5331140 SGTC_187 1488-2104 32.728 µM 0.933436123575113 0.215391778942718 no 743 0.175297418242623 911 2852859 SGTC_2981 9013952 38.96 µM 0.932069442193527 0.215733532752781 no 744 0.175650319506004 791 2996344 SGTC_1306 1185-0270 9.02 µM 0.931454700056368 0.215887358266077 no 745 0.175809203458437 903 1548076 SGTC_2521 angolensin 13.4 µM 0.931125939084793 0.215969649446635 no 746 0.175894211137394 846 821428 A flavenoid. SGTC_2210 7115885 190.385 µM 0.931105449461458 0.215974778744815 no 747 0.175899509998056 887 2927039 SGTC_2506 ethyl hematommate 54.16 µM 0.928675185484246 0.216583662699281 no 748 0.176528722219807 784 3940691 An allergen. SGTC_2864 9034755 47.6 µM 0.928094929788151 0.216729188024815 no 749 0.176679164714929 938 4930451 SGTC_2960 9079389 5.97 µM 0.927284468810112 0.216932542340864 no 750 0.176889428017765 884 16457355 SGTC_1746 st038117 42 µM 0.926198860005501 0.217205107259265 no 751 0.177171322443056 863 2898218 SGTC_1035 k081-0041 55.2 µM 0.923891343258238 0.217785114515459 no 752 0.177771445325823 927 731709 SGTC_1785 bathophenanthroline 24 µM 0.923067863025467 0.217992316989545 no 753 0.177985920441184 851 72812 An iron chelator. SGTC_2353 9059630 146.67 µM 0.920720143786605 0.218583669013247 no 754 0.178598278242759 921 4779114 SGTC_2899 9053889 58.44 µM 0.919589868911444 0.218868695769836 no 755 0.178893561466212 890 6470052 SGTC_1484 3473-2379 286 µM 0.919521234361009 0.218886010552517 no 756 0.178911502066539 1062 671917 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.918372137821842 0.219176015925201 no 757 0.179212036173062 938 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3260 9137109 49.47 µM 0.916488094102165 0.219651982632756 no 758 0.179705474606021 767 17478346 SGTC_2614 arthonioic acid 13.39 µM 0.916131266673949 0.219742194891424 no 759 0.179799025164385 848 6710684 SGTC_2266 7929956 200 µM 0.914463707118658 0.22016406519256 no 760 0.180236619888974 883 2967153 SGTC_2965 9082772 38.63 µM 0.913847200681218 0.220320150621432 no 761 0.180398570291597 924 16459634 SGTC_1512 0259-0544 12.2 µM 0.912457019130755 0.220672345732961 no 762 0.180764092739744 935 18476 SGTC_87 0100-0052 35.5 µM 0.912184007733931 0.220741549585953 no 763 0.180835930528801 1062 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_500 h-89 112 µM 0.911408254459379 0.22093825797306 no 764 0.181040152989781 948 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3231 9132313 49.47 µM 0.911225552409661 0.220984600474818 no 765 0.181088271594734 893 4905967 SGTC_2815 7968870 71.43 µM 0.910802023859712 0.221092050180584 no 766 0.181199847969349 894 2977326 YHR190W ERG9 SGTC_2712 st079126 47.7 µM 0.91053293020189 0.221160335095964 no 767 0.18127076164694 853 3152970 SGTC_154 3389-1638 511.116 µM 0.910171629015715 0.221252037467431 no 768 0.181366001906848 782 5238686 SGTC_1120 ficusin 1.78878 µM 0.910109580980693 0.22126778815605 no 769 0.181382361138251 912 6199 A DNA cross-linker. SGTC_3296 9122258 64.045 µM 0.909496640079672 0.221423415634084 no 770 0.181544015281688 890 4730474 SGTC_2809 7964133 12.99 µM 0.906566895559048 0.222168150212321 no 771 0.182317937257633 886 1253665 SGTC_3011 9081274 71.4286 µM 0.905279818330988 0.222495773815672 no 772 0.182658582674194 931 6625322 SGTC_438 sphingosine 6.67 µM 0.903350501642946 0.222987394165634 no 773 0.183169950760224 825 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1103 duloxetine 36.1 µM 0.902679163823778 0.2231586066298 no 774 0.183348099004346 1001 60835 A selective serotonin reuptake inhibitor. SGTC_818 4072-2707 53.5 µM 0.902051502356451 0.223318747912073 no 775 0.183514754840226 904 882871 SGTC_1121 fusaric acid 630.51 nM 0.900899726932149 0.223612781458256 no 776 0.183820818216529 913 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1574 spiramycin 23.7 µM 0.900535312262083 0.223705857694039 no 777 0.183917720963151 927 6419898 An antibiotic and protein synthesis inhibitor. SGTC_821 1114-0266 29.2 µM 0.900403561280256 0.223739514025128 no 778 0.183952763144001 887 3123235 SGTC_3075 9116269 49.47 µM 0.899983567737931 0.223846822318247 no 779 0.18406449776165 906 17015205 YNL244C SUI1 SGTC_2661 dactinomycin 12.96 µM 0.898933238850376 0.224115309212437 no 780 0.184344111003366 946 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1736 st036774 51 µM 0.898735903994815 0.224165772693141 no 781 0.184396673965684 956 1272247 SGTC_1176 0848-0131 83.3 µM 0.898549857470879 0.224213355373039 no 782 0.184446238657619 978 6769040 SGTC_804 1595-0054 20.9 µM 0.897725809511955 0.224424180260001 no 783 0.184665873071307 866 761523 Stimulates phospholipase C. SGTC_1810 st050138 53 µM 0.897231661038376 0.224550657421531 no 784 0.18479765697008 911 3444541 SGTC_3282 9108498 15.4605 µM 0.896678668743331 0.224692243580744 no 785 0.184945203155581 862 16459645 SGTC_194 1486-1323 56.904 µM 0.895516776999331 0.224989895059656 no 786 0.185255450747034 909 5178754 SGTC_896 0964-0007 44.5 µM 0.893737601518224 0.225446114046414 no 787 0.185731150964073 956 6756758 SGTC_1710 st031758 61.5 µM 0.891155772536659 0.226109081138421 no 788 0.186422803836289 910 5394341 SGTC_432 NS 1619 61.3 µM 0.891134777931029 0.226114476686706 no 789 0.18642843466736 851 4552 A K+/calcium channel activator. SGTC_2589 lobaric acid 100 µM 0.890715802570311 0.226222167264353 no 790 0.186540827440795 901 73157 A novel microtubule depolymerizer. SGTC_2069 5228469 200 µM 0.890668567554142 0.226234310049113 no 791 0.186553501162187 869 2835210 SGTC_1224 0823-0416 294 µM 0.889414124313075 0.226556926596855 no 792 0.186890278426455 937 3598164 SGTC_2191 5911152 200 µM 0.889215603404965 0.226608005811911 no 793 0.186943609301257 937 2875902 SGTC_3303 9125618 40.5795 µM 0.887726480845465 0.226991362629098 no 794 0.18734394898265 967 22695467 SGTC_2508 celastrol 40.54 µM 0.886148177981273 0.227398076774726 no 795 0.187768842225313 877 122724 Celastrol is a natural product and antioxidant. SGTC_3095 9117207 49.47 µM 0.885812947965371 0.22748451529668 no 796 0.18785916571876 893 17015229 SGTC_1461 k072-0203 53.8 µM 0.885217567143318 0.227638078896575 no 797 0.188019649689339 885 5418714 SGTC_1801 st050089 28.441 µM 0.881771915108927 0.228527944053998 no 798 0.188950081056961 990 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1662 st014054 52 µM 0.880614512874026 0.228827289598133 no 799 0.189263250386824 919 2838777 SGTC_3189 9110682 49.47 µM 0.879967434527181 0.22899474303896 no 800 0.189438475716415 917 17122418 SGTC_1449 4112-4002 201 µM 0.878433093952507 0.22939208030536 no 801 0.189854365743308 874 2059539 SGTC_227 fluconazole 33.516 µM 0.877616217510267 0.229603778521831 no 802 0.190076012662645 969 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1184 1269-1718 139 µM 0.876061755670145 0.230006928362558 no 803 0.190498231106896 967 5403821 SGTC_784 4579-0127 173 µM 0.875787588218926 0.230078074794089 no 804 0.190572759376126 1002 1948547 SGTC_1097 itavastatin 7.23 µM 0.875053203784037 0.230268708149444 no 805 0.190772478834047 971 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1347 1493-0251 600 nM 0.874663574523359 0.230369884946271 no 806 0.190878492556001 999 3986378 SGTC_440 fluspirilene 35.1 µM 0.872205658104402 0.231008715901281 no 807 0.191548096680291 943 3396 An atypical antipsychotic. SGTC_3297 9117502 71.43 µM 0.869023119652792 0.231837348729829 no 808 0.192417242636654 964 7453720 SGTC_315 k915-0449 187 µM 0.865774170320254 0.232684977973628 no 809 0.193307008269339 1018 20970215 YNL149C PGA2 SGTC_2753 fluvastatin 17.09 µM 0.864995348907527 0.23288842293738 no 810 0.193520670805601 937 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_3104 9120930 49.47 µM 0.861567683301826 0.233784976616268 no 811 0.194462730442229 899 17014836 SGTC_2666 tannic acid 100 µM 0.861497846009458 0.233803263395808 no 812 0.194481953495619 989 16134267 A thiamine antagonist. SGTC_2545 solidagenone 89.61 µM 0.861414214224803 0.233825163283396 no 813 0.194504975071727 750 6708572 An anti ulcer agent SGTC_828 2074-0507 139 µM 0.858984230494069 0.234461976955441 no 814 0.195174608133176 977 X828 SGTC_2850 9015429 58.44 µM 0.857723233433279 0.234792817936863 no 815 0.195522653866895 928 6457570 SGTC_676 falcarinol 140 µM 0.857067297582489 0.234965014259639 no 816 0.195703846572566 1009 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_359 0081-0058 15.9 µM 0.853775808190087 0.235830149023816 no 817 0.196614610541229 890 3494159 SGTC_180 1486-1293 102.781 µM 0.852615297691397 0.236135595713316 no 818 0.196936338196996 974 4140536 SGTC_1631 benzylvanillin 81.9 µM 0.851896610679087 0.236324863552187 no 819 0.197135739084503 951 75506 SGTC_541 4513-1321 94 µM 0.850041662648754 0.236813754060971 no 820 0.197650961741094 890 747515 SGTC_2524 avocatin b 10.57 µM 0.850000177808369 0.236824694168881 no 821 0.197662493694657 946 6710748 SGTC_558 k064-0027 21.3 µM 0.848875640302492 0.237121355611705 no 822 0.197975247462169 981 5088526 SGTC_1371 2421-0008 32.7 µM 0.848655945448897 0.237179336596915 no 823 0.198036383367065 932 2827552 SGTC_190 3970-0790 3.722 µM 0.848055234795185 0.237337913500756 no 824 0.198203605194021 952 2832352 SGTC_1813 st051246 8.6015 µM 0.847325200641795 0.237530707848482 no 825 0.198406941934834 949 5291959 SGTC_1872 amphotericin b 148 nM 0.847092323061755 0.237592226448265 no 826 0.198471831902543 1005 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2007 4011539 71.82 µM 0.846930851741993 0.237634886994311 no 827 0.198516832451655 952 45595301 SGTC_2756 carbadox 75.1 µM 0.846793728738711 0.237671118041631 no 828 0.198555052184713 935 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_613 3914-0030 117 µM 0.844155068989535 0.23836890251828 no 829 0.199291379175454 776 1145395 SGTC_1986 st071812 45 µM 0.843058725304894 0.238659156405897 no 830 0.199597800536954 948 11838594 SGTC_3350 9150499 3.57 µM 0.842971478835541 0.238682262966789 no 831 0.199622197565158 1029 4910996 YPR165W RHO1 SGTC_1151 3909-8316 15.3 µM 0.842890652213156 0.238703670372544 no 832 0.19964480099081 971 800431 SGTC_2699 st077704 54.6 µM 0.842553165787666 0.238793066984974 no 833 0.199739196796999 963 645852 SGTC_209 4077-0173 175.592 µM 0.840908660005006 0.23922894124783 no 834 0.200199553279389 886 15993494 SGTC_654 1124-0271 80.9 µM 0.840722180885713 0.239278394739931 no 835 0.200251795733039 981 5403748 SGTC_1494 4358-1428 177 µM 0.839750360235695 0.239536207934781 no 836 0.20052418556093 1027 1564571 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.837935546532765 0.240018063572014 no 837 0.201033451714198 961 6710655 SGTC_3062 9077494 49.47 µM 0.836164087013567 0.240488917403379 no 838 0.20153129946185 954 16459633 SGTC_229 benomyl 22.8748 µM 0.836156298560637 0.240490988683745 no 839 0.201533489944212 986 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1492 4158-0558 28.5 µM 0.835551314776356 0.240651909244039 no 840 0.20170368366528 982 3967268 SGTC_1651 st011928 86.1 µM 0.83533801049001 0.240708660349449 no 841 0.20176371083538 972 720198 SGTC_3215 9129942 49.47 µM 0.834393246935668 0.240960108890699 no 842 0.202029710709531 937 17682944 SGTC_343 4130-2827 29.8 µM 0.833725843409227 0.241137824212773 no 843 0.20221774580978 977 1118244 SGTC_98 0074-0023 107.663 µM 0.833349446888383 0.241238081992312 no 844 0.202323838391618 1024 3563821 SGTC_1493 4348-0038 111 µM 0.832740550970595 0.241400316762357 no 845 0.202495534623771 1067 800424 SGTC_879 0831-1030 162 µM 0.832603093743392 0.241436949186919 no 846 0.202534306807624 995 1549252 SGTC_1195 1502-0147 41.1 µM 0.831849940427284 0.241637718536476 no 847 0.202746825465394 1028 817940 SGTC_332 4112-0506 40.9 µM 0.830115451179404 0.242100428785105 no 848 0.203236755980458 986 2790355 SGTC_2603 homopterocarpin 100 µM 0.829008944642036 0.242395862706072 no 849 0.203549672923743 988 101795 A weak amylase inhibitor. SGTC_3315 9136395 68.55 µM 0.828827130718267 0.242444425154808 no 850 0.203601116864046 1049 16876844 SGTC_1518 st038567 90.8 µM 0.8265568401855 0.243051262697447 no 851 0.204244144355342 1002 77966 SGTC_1581 himbacine 57.9 µM 0.826161876406701 0.243156918407351 no 852 0.204356135592846 973 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2919 7978188 46.38 µM 0.825538946423724 0.243323607207366 no 853 0.204532840497559 1010 2980291 SGTC_2286 7945697 125 µM 0.823910059847377 0.243759769979652 no 854 0.204995331987567 1016 1245733 SGTC_1134 3477-0009 42.5 µM 0.821427698942819 0.244425276229724 no 855 0.205701345731905 1022 3973534 SGTC_1516 st013856 110 µM 0.819277240530103 0.245002591881004 no 856 0.20631412735533 948 5281404 A mutagen and neurotoxin. SGTC_3212 9128307 49.47 µM 0.818607508639059 0.245182538915781 no 857 0.206505190815273 876 27243542 SGTC_3257 9139206 32.98 µM 0.817971691413983 0.245353439322104 no 858 0.206686675935215 994 4910041 SGTC_1435 4092-0789 56.7 µM 0.81770012028946 0.245426454046673 no 859 0.206764220884203 1035 2248285 SGTC_1335 1486-0900 202 µM 0.817559359831291 0.245464303555434 no 860 0.206804420676868 1056 X1335 SGTC_2189 6047310 154.431 µM 0.817310162146083 0.245531318771291 no 861 0.206875600412762 991 711535 SGTC_361 000s-0510 1.45 µM 0.817282337710496 0.245538802037251 no 862 0.206883548962581 990 660 SGTC_1062 mesoridazine 14.2 µM 0.817030805720676 0.245606456077109 no 863 0.206955411796108 1013 4078 A neuroleptic. SGTC_674 0498-0004 451 µM 0.816541638839832 0.245738054946382 no 864 0.20709520934517 973 4231473 SGTC_1034 k072-0165 12.7 µM 0.816497462210481 0.245749941495364 no 865 0.207107837202593 1035 5835461 SGTC_2735 sertaconazole 140 nM 0.811305782935751 0.247149007351281 no 866 0.208595044949694 1013 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2064 5220758 200 µM 0.810807007240997 0.247283642522377 no 867 0.208738254896124 1057 788518 SGTC_1943 st076331 65.2 µM 0.808892488126522 0.247800795070126 no 868 0.209288495069759 1112 24208415 SGTC_3281 9140613 49.47 µM 0.808312280066125 0.247957635605561 no 869 0.209455417517237 985 16013766 SGTC_2721 ifenprodil 61.44 µM 0.808255660480126 0.247972943720957 no 870 0.209471710832973 1020 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2185 6113692 200 µM 0.808240469853303 0.247977050863781 no 871 0.20947608233901 971 874150 SGTC_12 0849-0099 9.267 µM 0.806900070023193 0.2483396023216 no 872 0.209862029240629 1001 6071388 SGTC_2358 9037157 4 µM 0.806726136190509 0.248386668662898 no 873 0.209912141352343 1014 2388925 SGTC_2126 5251174 33.877 µM 0.805477908880988 0.24872457731776 no 874 0.210271974656454 1095 790722 SGTC_2938 9059746 27.26 µM 0.805310362637561 0.248769952527983 no 875 0.210320301685066 968 6471769 SGTC_1550 gossypolone 36.6 µM 0.805238473174966 0.248789423127874 no 876 0.210341039476736 1072 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2080 5212524 12.4 µM 0.802874930555818 0.249430018511363 no 877 0.211023513644489 1018 260183 SGTC_1040 k898-0338 155 µM 0.802742486210301 0.249465941070438 no 878 0.211061795386735 1097 20969351 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.802633090365106 0.24949561431374 no 879 0.211093418254902 1047 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3120 9124077 49.47 µM 0.798920802386594 0.250503670260855 no 880 0.212168167951616 1123 18774327 YGL155W CDC43 SGTC_1745 st081495 74 µM 0.79808282813947 0.250731516789626 no 881 0.212411212863871 1055 13842402 YBL026W LSM2 SGTC_2155 5570423 76 µM 0.79703462756532 0.251016678611105 no 882 0.212715460426899 972 797402 SGTC_3236 9132701 49.47 µM 0.795026695631076 0.251563413157998 no 883 0.213298986760482 1018 24282524 SGTC_2203 7227154 166.4 µM 0.794722165627076 0.251646387747737 no 884 0.213387567850399 1061 896304 SGTC_779 1360-0071 233 µM 0.794121406160226 0.251810117675315 no 885 0.213562378451283 1112 7566 SGTC_529 4076-0302 30.3 µM 0.792084848641171 0.252365575696732 no 886 0.214155601988643 995 5816522 SGTC_559 1550-0661 158 µM 0.791435977211997 0.252542686799208 no 887 0.214344811282171 1048 5830875 SGTC_2580 diallyl disulphide 81.36 µM 0.791403098943604 0.252551662748825 no 888 0.214354401090752 996 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2463 5473429 200 µM 0.790944681117774 0.252676830864886 no 889 0.214488136655536 1012 5399405 SGTC_2557 derrustone 83.84 µM 0.790337527472993 0.252842660642862 no 890 0.214665338006787 1083 629853 An antioxidant. SGTC_3172 9105863 49.47 µM 0.788465915184815 0.253354207927208 no 891 0.215212114108155 1033 2348785 SGTC_2764 methyldopa 94.69 µM 0.788257610115028 0.253411175294973 no 892 0.215273018666315 1051 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_416 estradiol valerate 100 µM 0.787390148463442 0.253648481485549 no 893 0.215526755978457 1056 13791 A steroid. SGTC_2438 5259590 200 µM 0.78592897216159 0.25404847029278 no 894 0.215954550023879 1087 1201127 SGTC_2347 9049783 174.81 µM 0.785501824934779 0.254165461922721 no 895 0.216079700380497 1073 6467988 YPL169C MEX67 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.784587046748003 0.254416106128933 no 896 0.216347863563592 991 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1390 3413-2614 145 µM 0.782849515225202 0.254892536681449 no 897 0.216857743340402 1125 3421432 SGTC_1213 1315-0166 115 µM 0.782818549754979 0.254901031635704 no 898 0.216866836474422 959 768401 SGTC_1415 3966-0071 78.1 µM 0.782676177518153 0.25494009142295 no 899 0.216908647486961 1050 2893185 SGTC_408 cantharidin 100 µM 0.781994105888176 0.255127261038422 no 900 0.217109018758616 1038 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2264 7948757 110.76 µM 0.781896293998274 0.255154107825516 no 901 0.217137761591986 1089 2971411 SGTC_1952 st077036 64.1 µM 0.781243151919263 0.255333415984468 no 902 0.217329749142423 1110 2937007 SGTC_2129 girgensonine 121.053 µM 0.773868789671114 0.257362472471366 no 903 0.21950419390559 1110 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_184 1494-0393 24.714 µM 0.773715478033371 0.257404744917216 no 904 0.219549532426893 1086 3090647 SGTC_368 fentichlor 4.58 µM 0.773002515906241 0.25760137655368 no 905 0.219760445841208 1024 7329 A pesticide. SGTC_2998 9066762 71.4286 µM 0.77045793905893 0.258303794465678 no 906 0.220514147967959 1078 4945196 SGTC_3267 9137951 49.47 µM 0.767379203417701 0.259154989385096 no 907 0.221428044815077 1082 16643986 SGTC_426 0988-0037 14.6 µM 0.767171705741951 0.259212409518413 no 908 0.221489716554433 1110 5383008 SGTC_423 5-fluorouracil 457 µM 0.765877853210307 0.259570601258095 no 909 0.221874492353524 1049 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_819 1013-0258 27.7 µM 0.763518472401317 0.260224432477942 no 910 0.222577125014697 1107 5753198 SGTC_631 k072-0230 41.5 µM 0.76310050041969 0.26034034923758 no 911 0.22270173081771 1107 5773147 SGTC_802 4112-3352 742 µM 0.761721223851113 0.26072305459219 no 912 0.223113202699709 1119 704594 SGTC_329 k048-0121 21.3 µM 0.760219212809008 0.261140143900388 no 913 0.22356178123581 1089 6832902 SGTC_1959 st077091 55.8 µM 0.759683432308078 0.261289006249029 no 914 0.223721917166188 1133 821356 YKL052C ASK1 SGTC_1947 st076332 61.6 µM 0.75883900733955 0.261523711473544 no 915 0.223974434157641 1094 24208416 SGTC_413 propylparaben 100 µM 0.757825674918964 0.261805506789516 no 916 0.224277674919569 1072 7175 A pharmaceutical preservative. SGTC_1240 0356-0016 42.1 µM 0.757722458000897 0.261834218886145 no 917 0.224308575762816 1062 4305613 SGTC_1480 1070-0044 41.2 µM 0.757267059911531 0.261960917339977 no 918 0.224444940647187 1106 3124987 SGTC_1086 cerivastatin 2.18 µM 0.757021125379622 0.262029353017032 no 919 0.224518603102776 1083 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_900 1112-0045 141 µM 0.756411196394327 0.262199116193188 no 920 0.224701348574344 999 56211 YIL048W NEO1 SGTC_1250 0485-0349 40.2 µM 0.754906303807599 0.262618217908587 no 921 0.225152601573838 1092 6842794 YDL195W SEC31 SGTC_2202 7226349 200 µM 0.754357356168086 0.262771181144914 no 922 0.22531733522342 1084 844334 SGTC_2976 9009005 19.48 µM 0.754195178539293 0.262816380357465 no 923 0.225366016151417 1118 2993148 SGTC_1846 st056244 14.8 µM 0.753556834098123 0.262994326780609 no 924 0.225557686115735 1100 5393182 SGTC_1608 st001473 40.5 µM 0.753155220973705 0.263106312968528 no 925 0.225678322153462 1058 7292267 SGTC_484 loperamide 105 µM 0.752029723110541 0.26342027764054 no 926 0.226016592186624 1061 3955 An opioid-receptor agonist. SGTC_375 3970-0961 9.27 µM 0.751268184255047 0.263632822104051 no 927 0.226245636290298 1080 2898222 SGTC_321 4534-3890 65.3 µM 0.750642103649369 0.263807625862283 no 928 0.226434037497813 1138 699746 SGTC_1288 0973-0013 65.5 µM 0.749550557105714 0.264112530516225 no 929 0.226762719264997 1130 4315430 SGTC_168 3970-0862 530.542 µM 0.749321824681661 0.264176445708316 no 930 0.226831628281302 1155 3135186 SGTC_3157 9099274 49.47 µM 0.748483790315278 0.264410686740298 no 931 0.227084199397167 1107 17217662 SGTC_2740 felodipine 17.08 µM 0.748368013047694 0.264443056236447 no 932 0.22711910540783 1071 3333 L-type calcium channel blocker SGTC_143 4032-1194 15.74 µM 0.745194518960234 0.265331099649149 no 933 0.228077067921292 1128 1806963 SGTC_2906 7926292 26.41 µM 0.744910479902288 0.265410656448573 no 934 0.228162919640128 1110 2966319 SGTC_2368 9071271 200 µM 0.744771854834965 0.265449488485102 no 935 0.228204826109506 1111 27209959 SGTC_331 k048-0133 24.5 µM 0.743749409439838 0.265735987726603 no 936 0.228514045796764 1114 6813582 SGTC_2745 rifampicin 24.3 µM 0.743240071836498 0.265878767599971 no 937 0.228668173316781 1028 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2890 9046729 58.44 µM 0.742069024569651 0.26620718836179 no 938 0.229022758028831 1059 903329 SGTC_262 fenpropimorph 62.5 µM 0.740980890587087 0.266512540019684 no 939 0.229352513498508 1052 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_998 3996-0085 177 µM 0.740350689945531 0.266689467607094 no 940 0.229543615399769 1169 715391 SGTC_2417 cerulenin 830 nM 0.739820130574897 0.266838467125358 no 941 0.229704571252465 1125 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_144 4161-2749 112.381 µM 0.737738499503066 0.267423467477485 no 942 0.230336686025883 1030 797501 YMR168C CEP3 SGTC_2513 baicalein 25.65 µM 0.737551306372839 0.267476106008045 no 943 0.230393577320249 1132 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_270 tamoxifen 5.46 µM 0.735692748506417 0.267999014029869 no 944 0.230958851857998 1206 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_3180 9109287 49.47 µM 0.735253026592637 0.268122805696055 no 945 0.231092705073374 1112 18891271 SGTC_2980 9014342 25.29 µM 0.735251608036425 0.268123205098285 no 946 0.231093136957948 1120 2996599 SGTC_471 1-acyl-paf 4 µM 0.73509349117058 0.26816772564018 no 947 0.231141279033403 1115 16759367 SGTC_1895 st058434 18.3 µM 0.733481543277667 0.268621809661829 no 948 0.231632390408851 1164 5393175 SGTC_907 3448-6986 75.5 µM 0.732867822365011 0.268794795701969 no 949 0.231819525204015 1165 590582 SGTC_1425 4048-4433 7.33 µM 0.731762069515493 0.269106609155861 no 950 0.232156902051335 1198 23734946 SGTC_64 000l-0018 272.079 µM 0.731262324819405 0.269247592689542 no 951 0.232309469040812 1118 6811119 SGTC_2300 7976697 71.57 µM 0.730641548786028 0.269422772084776 no 952 0.232499063327232 1046 2236109 SGTC_2750 bromebric acid 70.15 µM 0.730255757651211 0.269531668885438 no 953 0.232616933049728 1152 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_302 1094-0063 18.9 µM 0.730117581257645 0.26957067713436 no 954 0.232659157787968 1092 5440289 SGTC_1870 st057514 26.5 µM 0.729706575634937 0.269686723872743 no 955 0.232784780433591 1148 5393161 SGTC_1811 st050069 61.5 µM 0.727668004276252 0.270262680630616 no 956 0.233408420465169 1140 3877702 SGTC_189 3970-0742 2.116 µM 0.727574063985843 0.270289236359968 no 957 0.233437181015099 1164 2891807 SGTC_1921 5740136 50 µM 0.726056334218377 0.270718460047426 no 958 0.233902118138525 1151 1774243 SGTC_1247 0448-0043 5.84 µM 0.72365132506266 0.271399308219594 no 959 0.234639911512791 1170 3089013 YGL099W LSG1 SGTC_1974 st069448 26.9 µM 0.722152003915772 0.271824191148915 no 960 0.235100514157721 1139 6323587 YNR016C ACC1 SGTC_389 tpck 16.7 µM 0.721172056119319 0.272102070967039 no 961 0.235401831109342 1134 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2762 leflunomide 42.06 µM 0.719181122195017 0.272667066602724 no 962 0.236014664645989 1135 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1714 st033236 13.627 µM 0.71902217289339 0.272712198991012 no 963 0.236063629029673 1171 2916566 SGTC_2525 harmine 47.85 µM 0.718880396417647 0.272752458419725 no 964 0.2361073080409 1110 5280953 A monoamine oxidase inhibitor SGTC_2105 5350118 200 µM 0.717740203877896 0.273076339339768 no 965 0.236458744533161 1187 2133313 SGTC_1737 st035557 69.7 µM 0.716549717287729 0.273414709988329 no 966 0.236825989971079 1037 5716916 SGTC_1463 k081-0032 34.1 µM 0.716352123236221 0.273470892001515 no 967 0.236886974803633 1016 977755 SGTC_1819 st053448 58.6 µM 0.713770051188192 0.274205578656745 no 968 0.237684690789605 1132 2857616 SGTC_1672 st016598 6.51 µM 0.713030025345339 0.274416320573405 no 969 0.23791358885076 1112 4665860 YNL267W PIK1 SGTC_1948 st076329 66.6 µM 0.711441321592707 0.274869015805591 no 970 0.23840540024625 1093 24208413 SGTC_176 1486-1328 72.834 µM 0.711101917839574 0.274965775337396 no 971 0.238510540816258 1172 22310231 SGTC_3295 9122362 53.5725 µM 0.709309770896348 0.275476970873759 no 972 0.239066133153834 1172 4730473 SGTC_3035 9091303 49.47 µM 0.708796342476354 0.275623508314678 no 973 0.239225433910377 1198 25237002 SGTC_2617 dihydrotanshinone i 20.83 µM 0.708362339384818 0.275747406881884 no 974 0.239360136698117 1209 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1828 st055811 49 µM 0.706140289064712 0.276382183064721 no 975 0.24005044945759 1139 5877589 SGTC_1284 0929-0043 16 µM 0.7059947854169 0.276423774282768 no 976 0.240095690149256 1148 1239883 SGTC_2091 4-phenylthiadiazole 200 µM 0.705683139524832 0.276512866446343 no 977 0.240192604220868 1177 270010 SGTC_85 0868-0259 160.055 µM 0.705155302900157 0.276663794516872 no 978 0.24035679682185 1119 83173 SGTC_910 3454-3003 490 µM 0.701794231224969 0.277625795463868 no 979 0.241403748448708 1155 820824 SGTC_2403 6032726 181.2 µM 0.701543802552931 0.277697538150816 no 980 0.241481854372162 1188 2881040 SGTC_1650 st011916 45.8 µM 0.698457929117229 0.278582320203635 no 981 0.242445429711339 1181 242528 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.694779054091919 0.27963891857218 no 982 0.243596888350929 1194 97141 SGTC_781 4335-2806 94.4 µM 0.69310058429056 0.280121632038248 no 983 0.244123215509794 1268 845254 SGTC_645 0845-0943 5.41 µM 0.691996873188619 0.280439269763452 no 984 0.244469646306962 1182 1885106 SGTC_2312 7706453 155.7 µM 0.691637943488991 0.28054260393093 no 985 0.24458236354307 1215 976098 SGTC_118 0083-0097 135.343 µM 0.691047818856476 0.280712538071037 no 986 0.244767745388211 1281 5207356 SGTC_1394 3474-0001 65.7 µM 0.688911953667156 0.281328004366275 no 987 0.245439338272482 1145 5017666 YIL048W NEO1 SGTC_886 0866-0150 153 µM 0.68820538503912 0.28153175094049 no 988 0.245661726643128 1231 271463 SGTC_1741 st038134 10.228 µM 0.687419460226512 0.281758464300644 no 989 0.245909218979769 1254 1272587 SGTC_675 1309-0189 238 µM 0.684108124340707 0.28271464065792 no 990 0.24695344601678 1189 4246530 SGTC_366 0181-0206 4.31 µM 0.682554465270629 0.283163809673947 no 991 0.247444207730646 1233 274874 SGTC_648 0375-0473 33.3 µM 0.68150596267153 0.283467129318972 no 992 0.247775697572149 1215 1713139 SGTC_2883 9059145 45.46 µM 0.68086823143222 0.283651693706503 no 993 0.24797743570144 1214 16476510 SGTC_1431 4049-0260 9.09 µM 0.680246733133945 0.283831615519272 no 994 0.248174123046615 1207 3854841 SGTC_935 2996-0153 430 µM 0.679798183565086 0.283961503151479 no 995 0.248316128489519 1226 23738523 SGTC_2310 7668677 200 µM 0.67958914309206 0.284022045244452 no 996 0.248382323005006 1251 2197143 SGTC_2659 sanguinarine 24.21 µM 0.678879176317069 0.284227711203044 no 997 0.24860721046669 1176 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1530 rhein 70.4 µM 0.677369348117882 0.284665320713376 no 998 0.249085820579842 1259 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2939 9044578 71.43 µM 0.673886153520651 0.285676117109214 no 999 0.250191847921045 1220 2653634 SGTC_2670 beta-carotene 100 µM 0.673583450378271 0.285764039829788 no 1000 0.250288088854434 1171 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.67229835696356 0.286137449457098 no 1001 0.250696887771646 1193 77254 SGTC_2133 5320837 200 µM 0.669259305409059 0.287021427778709 no 1002 0.251665040538678 1222 2841355 SGTC_1265 0819-1001 68.8 µM 0.66916502260382 0.287048872783253 no 1003 0.251695107827729 1239 3106768 SGTC_2737 bleomycin 30.5 nM 0.668999918942288 0.287096936191712 no 1004 0.251747764834835 1255 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2422 chlorphenesin carbamate 384.24 µM 0.667462990838656 0.287544534829251 no 1005 0.252238220917446 1254 2724 A muscle relaxant with antifungal properties. SGTC_2794 7785382 27.27 µM 0.666403161614773 0.287853380319323 no 1006 0.252576721103269 1225 2205081 SGTC_119 0121-0043 24.815 µM 0.665429511749486 0.288137250233371 no 1007 0.25288790713897 1303 1092378 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.663061405956441 0.288828227813012 no 1008 0.253645613551875 1312 688664 SGTC_2443 5493264 126.67 µM 0.662844896540013 0.288891440894027 no 1009 0.253714948013596 1254 5340055 SGTC_1117 retinoic acid 1.10837 µM 0.661717242446833 0.289220781168133 no 1010 0.254076226127225 1261 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2937 9044753 11.33 µM 0.661608158314876 0.289252649409628 no 1011 0.254111188839825 1252 6465530 YGL099W LSG1 SGTC_772 k072-0172 35.3 µM 0.660624996961349 0.289539948248479 no 1012 0.254426417137285 1174 5861980 SGTC_2800 7887935 81.82 µM 0.660098980814247 0.289693715384862 no 1013 0.254595156348183 1237 2961002 SGTC_47 0149-0135 24.25 µM 0.659886181884929 0.289755932502536 no 1014 0.254663436156326 1200 5239155 SGTC_2259 7964009 200 µM 0.655792903135882 0.290953923873182 no 1015 0.255978691649285 1275 313134 SGTC_2018 5133068 143 µM 0.654176469804909 0.291427646580806 no 1016 0.256499059667383 1260 785362 SGTC_1799 st045822 46.1415 µM 0.653370491342152 0.291663986351165 no 1017 0.256758728887403 1245 3674992 SGTC_2383 9036125 200 µM 0.653054216892266 0.291756752971538 no 1018 0.256860663201211 1210 79580 SGTC_2842 9000675 19.48 µM 0.650991499138741 0.292362106741795 no 1019 0.257525987208694 1210 2989072 SGTC_1723 st034307 2.5525 µM 0.650774967969847 0.292425686840956 no 1020 0.257595880626439 1292 867466 SGTC_1716 st033144 30.6155 µM 0.65026364462098 0.292575852345145 no 1021 0.257760968177112 1283 674617 SGTC_1636 st007707 68.9 µM 0.646886112466102 0.293568665231712 no 1022 0.258852827251246 1287 403051 SGTC_1515 3460-0031 42.1 µM 0.64414127625533 0.294376646694557 no 1023 0.259741913281556 1236 2876596 SGTC_2242 6630449 61.2675 µM 0.642970548671055 0.294721579042473 no 1024 0.260121605141362 1291 691249 YDR170C SEC7 SGTC_1041 0206-0046 107 µM 0.642826317623813 0.294764086836634 no 1025 0.260168402126331 1291 50494 SGTC_92 0063-0024 660.874 µM 0.641632198970123 0.295116126186153 no 1026 0.260556010655846 1303 3594437 SGTC_11 0438-0307 1.3 µM 0.638595835494229 0.296012150557079 no 1027 0.261542945591404 1294 4011476 SGTC_2097 5376186 200 µM 0.638359040638469 0.296082080675079 no 1028 0.261619993616096 1248 742755 SGTC_482 fipronil 114 µM 0.636619940734232 0.296595902791011 no 1029 0.262186216579308 1315 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2639 lactacystin 53 µM 0.63655247727904 0.296615843292219 no 1030 0.262208194239962 1306 3870 A proteasome inhibitor. SGTC_2053 5265679 138 µM 0.635197003407963 0.297016617336432 no 1031 0.262649968695839 1260 764595 SGTC_317 4495-0002 170 µM 0.634398324154169 0.297252879375882 no 1032 0.262910451499078 1249 15991618 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.633006277080139 0.297664874230405 no 1033 0.263364771943347 1270 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1199 1638-0010 4.46 µM 0.631603813387474 0.298080215328612 no 1034 0.263822897062154 1284 3111136 SGTC_2813 7971799 71.43 µM 0.630594198349483 0.298379377255308 no 1035 0.264152946630506 1332 2234054 SGTC_1990 st072050 59.8 µM 0.630088809264331 0.298529181851224 no 1036 0.264318240489413 1287 17233948 SGTC_2416 tofa 880 nM 0.629913238379572 0.298581231593623 no 1037 0.264375675478531 1227 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_746 1095-0025 46.6 µM 0.62822041262045 0.299083298306514 no 1038 0.264929779989876 1290 6749286 SGTC_3219 9131112 49.47 µM 0.623866958685837 0.300376224190714 no 1039 0.266357480587544 1252 17612988 YMR079W SEC14 SGTC_1509 1326-1131 80 µM 0.622704504122118 0.300721886600169 no 1040 0.266739361163982 1277 768313 SGTC_2111 5486399 200 µM 0.619105494280427 0.301793208823347 no 1041 0.267923432032455 1315 689674 SGTC_1044 1222-0021 1.78 µM 0.618559958267404 0.301955748898542 no 1042 0.268103143626222 1334 4306703 SGTC_2826 7992541 19.48 µM 0.618258045866026 0.302045719282138 no 1043 0.268202626303487 1370 2985066 SGTC_1504 k297-0033 30 µM 0.615033551907608 0.303007373575705 no 1044 0.269266281423959 1220 4388117 SGTC_728 3030-5151 22.5 µM 0.614824945049533 0.303069634428276 no 1045 0.269335166799146 1344 3125388 SGTC_1303 1160-0052 261 µM 0.614525986749389 0.303158871570573 no 1046 0.269433903093179 1341 3562476 SGTC_446 go6976 132 µM 0.61429559772112 0.303227649239425 no 1047 0.269510005543416 1290 3501 A protein kinase C inhibitor. SGTC_3158 9100007 49.47 µM 0.613358403839633 0.303507500114357 no 1048 0.269819691836916 1304 19297233 SGTC_2100 5377183 190 µM 0.612317601783923 0.303818424033612 no 1049 0.27016382308925 1344 2844202 SGTC_2717 st081029 62.2815 µM 0.610240770961336 0.304439270169164 no 1050 0.270851162762755 1296 5292846 SGTC_1260 0700-1617 7.75 µM 0.609372336057224 0.304699046719095 no 1051 0.271138835084737 1358 2853078 SGTC_1971 st069429 63.5 µM 0.609127265793783 0.304772372871015 no 1052 0.271220043084718 1313 1246522 YGL099W LSG1 SGTC_1807 st050092 58.9 µM 0.609089337279045 0.304783721958271 no 1053 0.271232612395644 1301 5008496 SGTC_3326 9140064 16.379 µM 0.608504867827166 0.304958632457251 no 1054 0.271426339214733 1302 1868434 SGTC_1313 1220-0047 237 µM 0.607924057476036 0.30513249207716 no 1055 0.271618921463192 1375 3528706 SGTC_3207 9114163 49.47 µM 0.607143579718642 0.305366189348902 no 1056 0.271877815543591 1443 849233 SGTC_1919 st067113 52.3 µM 0.606346353199076 0.305604983599925 no 1057 0.272142392081199 1334 1268243 SGTC_2819 7996655 46.38 µM 0.605911335783758 0.305735319792377 no 1058 0.272286815795472 1267 6456960 SGTC_2643 anethole 100 µM 0.605210453957576 0.305945363771794 no 1059 0.272519585308395 1315 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2094 5332512 191.667 µM 0.604023440265338 0.306301239903809 no 1060 0.272914029053787 1405 755774 SGTC_1926 methyl fluorone black 53.6 µM 0.602502180438347 0.306757592946968 no 1061 0.273419956109577 1203 72721 Reacts with homocysteine. SGTC_2181 6316240 54.2555 µM 0.602470954156871 0.306766963461403 no 1062 0.273430345930092 1314 12779990 SGTC_2816 7982706 58.44 µM 0.602462389023899 0.306769533744751 no 1063 0.273433195813484 1334 2981853 SGTC_2260 7964312 200 µM 0.602411802591862 0.306784714259034 no 1064 0.273450027776483 1384 231951 SGTC_1046 2001-0062 216 µM 0.599979367790059 0.307515055825516 no 1065 0.274259992952593 1315 739778 SGTC_1013 4112-3890 241 µM 0.599691499171057 0.307601539329122 no 1066 0.274355927329418 1301 705171 SGTC_732 3970-1727 52.7 µM 0.599601347742611 0.307628625450847 no 1067 0.27438597437516 1375 1275699 SGTC_1982 st072467 71.9 µM 0.598026868216056 0.308101848999773 no 1068 0.274911002729763 1333 3163533 SGTC_464 bw-b 70c 158 µM 0.597013264604152 0.308406665353778 no 1069 0.275249262285386 1373 5353454 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.59434376009689 0.309210084980918 no 1070 0.276141107852504 1534 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_761 k216-0224 480 µM 0.590150865304506 0.310473830053001 no 1071 0.277544754962897 1414 1340404 SGTC_991 3996-0057 64.7 µM 0.587696917937582 0.31121449405044 no 1072 0.278367872334637 1369 715343 SGTC_1845 st056753 3.01 µM 0.58721030565468 0.311361457055694 no 1073 0.278531235913117 1287 5375839 SGTC_147 4466-0538 29.23 µM 0.584355760588346 0.312224170352708 no 1074 0.279490492049273 1414 6742687 YHR072W ERG7 SGTC_933 2914-0560 114 µM 0.583349776242116 0.312528449266114 no 1075 0.279828930146394 1411 463887 SGTC_1857 st056007 79.3 µM 0.579620232074422 0.313657634442905 no 1076 0.281085373126839 1368 619834 SGTC_1015 4130-4525 82 µM 0.578977465209765 0.313852420319272 no 1077 0.281302189320639 1329 1363237 SGTC_612 0302-0167 22.4 µM 0.576937610281763 0.314470927122687 no 1078 0.281990801242678 1439 235821 SGTC_21 0849-0113 22.993 µM 0.576805045156056 0.314511140401138 no 1079 0.282035580509644 1336 1560156 SGTC_139 0099-0334 718.624 µM 0.575503794908897 0.31490598796803 no 1080 0.282475312431037 1387 97690 SGTC_1242 0402-0103 60.1 µM 0.574674258408683 0.315157810601698 no 1081 0.282755809945729 1329 432868 SGTC_89 0302-0250 142.109 µM 0.573744399790686 0.315440190187117 no 1082 0.283070389128122 1416 4203518 YLR208W SEC13 SGTC_1308 1187-1617 41.4 µM 0.573686086186732 0.315457902464495 no 1083 0.283090122718653 1371 2882570 SGTC_3032 9089427 49.47 µM 0.572053639231912 0.315953916762953 no 1084 0.283642817999147 1337 17173707 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.571394578618134 0.316154264424896 no 1085 0.283866101604191 1354 4174840 SGTC_1644 st010134 20.9 µM 0.571105518270983 0.316242152840729 no 1086 0.283964059096783 1357 3818134 SGTC_2099 5377090 177.372 µM 0.570496510762519 0.316427354743024 no 1087 0.284170494006203 1359 2243829 SGTC_22 0964-0034 14.468 µM 0.5700527591805 0.31656233058291 no 1088 0.284320957394507 1341 138402 SGTC_1802 st050112 57.9 µM 0.56997831622304 0.316584976277702 no 1089 0.284346202587737 1351 4662563 SGTC_1047 2043-3044 82 µM 0.568613825945603 0.317000178641195 no 1090 0.284809119980515 1341 669592 SGTC_1297 1068-0111 14.1 µM 0.568594558590826 0.317006043179206 no 1091 0.28481565920321 1331 767057 SGTC_2567 aureobasidin a 60 nM 0.566570126983401 0.317622489349448 no 1092 0.285503137833312 1469 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1136 pergolide 1.05886 µM 0.566397559295222 0.317675060213312 no 1093 0.285561776777266 1392 47811 A dopamine receptor agonist. SGTC_2041 5107442 45.335 µM 0.566066041244511 0.317776063885689 no 1094 0.285674443544297 1397 793005 SGTC_468 gf-109203x 121 µM 0.565778112299362 0.317863798260602 no 1095 0.285772313664676 1339 2396 A protein kinase C inhibitor. SGTC_204 PMA1.184 62.41 µM 0.5657257478164 0.317879755258715 no 1096 0.285790114624864 1391 2252213 YGL008C PMA1 SGTC_2215 7188065 200 µM 0.565057544447394 0.318083406162014 no 1097 0.286017312235267 1422 940217 SGTC_3136 9095672 49.47 µM 0.56316090546972 0.31866175162976 no 1098 0.286662660680017 1278 17217380 SGTC_2840 9008771 71.43 µM 0.562015574910136 0.319011213452558 no 1099 0.287052703776993 1402 2992978 SGTC_3334 9142812 21.919 µM 0.555540303463733 0.320989959687383 no 1100 0.289262575348728 1439 45283678 SGTC_1413 3910-0535 34.4 µM 0.554256133713018 0.321382989945851 no 1101 0.289701783339021 1464 2876951 SGTC_770 0389-1121 67.2 µM 0.553889846630442 0.321495131683446 no 1102 0.289827117120239 1500 6753108 SGTC_1465 k213-0056 144 µM 0.5513125711653 0.322284644830006 no 1103 0.290709711143594 1371 24048857 YMR208W ERG12 SGTC_333 3486-0131 40.1 µM 0.55009128375154 0.322659049990334 no 1104 0.291128382372578 1490 6744690 SGTC_1167 k781-0610 148 µM 0.549754121170398 0.32276244426388 no 1105 0.291244015123061 1440 4525169 SGTC_825 1988-2224 89.6 µM 0.548975909766579 0.32300114287035 no 1106 0.291510991106212 1427 1180859 SGTC_853 0419-0306 21 µM 0.547882678100892 0.323336589914843 no 1107 0.29188623173856 1351 762713 SGTC_2052 5265182 7.135 µM 0.545492015834829 0.324070640682262 no 1108 0.292707585146748 1500 1239884 SGTC_2568 diosmetin 100 µM 0.543815839723156 0.324585717535939 no 1109 0.293284103853503 1430 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1438 4092-1045 4 µM 0.541821886068418 0.325198882303134 no 1110 0.293970606375486 1405 1351342 SGTC_2561 acetosyringone 100 µM 0.541676738276186 0.325243535510062 no 1111 0.294020608614647 1388 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_629 3448-6466 76.7 µM 0.541193368836999 0.325392257175396 no 1112 0.294187153815143 1413 573744 SGTC_142 0335-0849 62.6745 µM 0.54083199015023 0.325503463259255 no 1113 0.294311695503439 1458 3889043 YPR107C YTH1 SGTC_3279 9140807 49.47 µM 0.536751236454885 0.326760298744047 no 1114 0.295719729599911 1427 45595718 SGTC_3283 9109332 35.8195 µM 0.536116819553051 0.326955870595476 no 1115 0.295938908224302 1376 17027281 SGTC_2003 4023581 200 µM 0.534791652563924 0.327364533449484 no 1116 0.296396967938132 1452 16641307 SGTC_41 0478-0632 82.643 µM 0.533083310561453 0.327891667462622 no 1117 0.296987955725414 1448 3750424 SGTC_763 3453-1109 128 µM 0.531626927302089 0.328341326881433 no 1118 0.297492205554981 1429 1560353 SGTC_2867 9039098 71.43 µM 0.531403162491575 0.328410436498773 no 1119 0.297569715239573 1402 6463460 SGTC_1486 3970-0793 4.53 µM 0.528653875068996 0.329260030772265 no 1120 0.29852278982364 1479 2844330 SGTC_2220 6782180 200 µM 0.528343355427421 0.329356044163901 no 1121 0.298630522531047 1422 833803 SGTC_439 amiodarone 34.4 µM 0.527415647173526 0.329642960714436 no 1122 0.298952489950551 1506 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1676 st018489 23.4 µM 0.524887422367493 0.330425385007266 no 1123 0.299830726725987 1472 3696235 SGTC_2303 7774051 200 µM 0.524797838043097 0.330453122812847 no 1124 0.299861867310199 1515 2953184 SGTC_2151 5563267 85.4165 µM 0.523543713172765 0.330841532588615 no 1125 0.300297969768619 1447 5310824 SGTC_1808 st050063 61.5 µM 0.513637885593075 0.333915798543683 no 1126 0.303752593333538 1507 4011993 SGTC_753 1322-0200 289 µM 0.512834516066464 0.334165616515266 no 1127 0.304033541597604 1454 5403907 SGTC_2061 5245884 80.95 µM 0.512731003248402 0.334197810488946 no 1128 0.304069749733359 1440 573863 SGTC_3356 9151811 4.48 µM 0.512403170259476 0.334299779307104 no 1129 0.304184436340479 1430 1859254 YPR165W RHO1 SGTC_219 mitoxanthrone 164.414 µM 0.511759962138395 0.334499877592481 no 1130 0.30440950736855 1503 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2949 9072542 2.23 µM 0.511164579907279 0.334685139434065 no 1131 0.304617909228153 1441 16457352 SGTC_2795 7780010 54.55 µM 0.508637110364558 0.335472046006928 no 1132 0.305503305876087 1468 953673 SGTC_455 paf C-16 10 µM 0.505111609792016 0.336570887137913 no 1133 0.306740223757703 1468 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_208 k072-0098 12.366 µM 0.504630710005663 0.336720884257463 no 1134 0.306909118031375 1470 5948901 SGTC_1053 3366-3204 134 µM 0.504336751298375 0.336812585509293 no 1135 0.307012377904726 1428 3632071 YPR165W RHO1 SGTC_3117 9124945 49.47 µM 0.503701998998364 0.337010631376293 no 1136 0.307235401713838 1364 17592065 SGTC_264 promethazine 12.5 mM 0.503280353223189 0.33714221193268 no 1137 0.307383588766528 1472 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1942 st076330 65.2 µM 0.502522798687197 0.337378667643783 no 1138 0.307649909668719 1492 24208414 SGTC_714 4296-0578 26.1 µM 0.5007435345546 0.337934282342785 no 1139 0.308275814667413 1510 1589775 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.499709767180914 0.338257261481523 no 1140 0.308639727051264 1452 2346 DNA damaging agent; causes G2/M arrest. SGTC_733 4069-0007 56.1 µM 0.498296430869383 0.338699021667466 no 1141 0.309137561567278 1507 5717425 YNL287W SEC21 SGTC_1708 st033234 31.827 µM 0.497057709257913 0.339086385899992 no 1142 0.309574178119033 1544 674664 SGTC_1417 3966-0327 90.4 µM 0.496111543105618 0.3393823789236 no 1143 0.309907857796574 1524 651118 SGTC_2782 7736369 71.43 µM 0.495453803333581 0.339588200761199 no 1144 0.31013991191036 1494 2950836 YOL077C BRX1 SGTC_1579 chlormadinone acetate 49.4 µM 0.494002514646746 0.340042511421792 no 1145 0.310652201779304 1573 45114258 A steroidal progestin. SGTC_2619 obliquin 87.91 µM 0.492449016937575 0.340529075033843 no 1146 0.311200977490215 1552 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1197 1601-0112 267 µM 0.49228156198918 0.340581538667728 no 1147 0.31126015632912 1454 7350313 SGTC_2931 9014674 55.67 µM 0.491915125139467 0.340696354088746 no 1148 0.311389672697873 1444 2996810 SGTC_1471 k673-0312 37 µM 0.491183863258839 0.340925524013549 no 1149 0.311648205516209 1482 24099884 SGTC_585 0kpi-0023 191 µM 0.489910781448145 0.341324634748532 no 1150 0.312098516734683 1558 64601 SGTC_138 0850-0259 40.9225 µM 0.488772457500695 0.341681649306741 no 1151 0.312501399676774 1480 6813004 SGTC_823 0417-1665 178 µM 0.488035610363229 0.341912823533452 no 1152 0.312762308930036 1532 3429856 SGTC_560 2332-1943 155 µM 0.48725058887875 0.342159176930751 no 1153 0.313040379418476 1514 21177716 SGTC_358 0075-0058 9.45 µM 0.485536455281181 0.342697335309865 no 1154 0.313647929788378 1687 1069125 SGTC_2071 5230951 39.92 µM 0.483279559540303 0.343406382816738 no 1155 0.314448625770908 1504 1799272 SGTC_1161 k007-0610 110 µM 0.481720730918532 0.343896441186615 no 1156 0.315002173582424 1557 5843850 SGTC_509 pifithrin 175 µM 0.481128282129064 0.344082761743817 no 1157 0.31521266420753 1579 4817 A p53 inhibitor. SGTC_874 0599-0792 117 µM 0.481076875751143 0.34409893043736 no 1158 0.315230931165818 1628 765305 SGTC_54 0159-0055 9 µM 0.479604224268866 0.344562240018701 no 1159 0.31575442102542 1623 3319099 SGTC_67 0335-0847 266 µM 0.477687154905608 0.345165716951336 no 1160 0.31643644405589 1749 4552207 YOR254C SEC63 SGTC_595 3909-8003 73.7 µM 0.475626591090486 0.345814803995568 no 1161 0.317170213862009 1540 699517 SGTC_534 k292-0788 63.4 µM 0.475317954273679 0.345912065097703 no 1162 0.317280181899815 1588 4146317 SGTC_3216 9129716 49.47 µM 0.47506387441556 0.345992141229113 no 1163 0.317370723270585 1442 8056934 SGTC_2435 5706476 10.6 µM 0.474605366605467 0.346136662562074 no 1164 0.317534140207011 1581 5725375 SGTC_679 0422-0091 41.4 µM 0.473629207893684 0.346444421714114 no 1165 0.317882171717377 1478 627384 YHR062C RPP1 SGTC_2332 7982454 138.89 µM 0.473116883059518 0.346605985888744 no 1166 0.318064896171661 1505 2981748 SGTC_1761 st044296 37 µM 0.473053900861636 0.346625849563567 no 1167 0.318087362298157 1488 1826700 SGTC_109 0132-0036 33.701 µM 0.472782788716649 0.346711359229057 no 1168 0.318184077262282 1465 67274 A color developer. SGTC_1361 1608-0041 5.61 µM 0.472162149015198 0.346907140436557 no 1169 0.318405527313149 1498 X1361 SGTC_1096 rimcazole 32.2 µM 0.469209971701568 0.347838965657821 no 1170 0.319459779271191 1515 18528119 A dopamine reuptake inhibitor. SGTC_1712 st032288 53.4 µM 0.466684091216721 0.348636965030462 no 1171 0.320362956711347 1497 2883011 SGTC_1950 st077106 7.18 µM 0.465663424028474 0.348959613919719 no 1172 0.320728218470618 1494 13831864 SGTC_3155 9099265 49.47 µM 0.464933621936767 0.349190382787645 no 1173 0.32098949608059 1563 25236499 SGTC_1153 4055-0057 267 µM 0.463990920673698 0.34948855450527 no 1174 0.321327125288488 1499 882706 SGTC_789 1309-1135 70.6 µM 0.463057254352951 0.349783960082787 no 1175 0.32166166422152 1497 3092424 SGTC_2314 7727897 200 µM 0.46270381655373 0.349895809105966 no 1176 0.321788341125359 1497 900724 SGTC_2352 9027995 87.8 µM 0.46226267261704 0.350035431913079 no 1177 0.321946482165491 1567 2997347 SGTC_82 0054-0107 293.755 µM 0.459247149042216 0.350990392420772 no 1178 0.323028347914663 1639 3104697 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.45863971314356 0.351182870299035 no 1179 0.323246456616593 1544 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_940 3232-1287 54.8 µM 0.458016476574943 0.351380394610942 no 1180 0.32347030194258 1530 1585493 YIL048W NEO1 SGTC_1783 st039459 87.517 µM 0.456967115511351 0.351713062568594 no 1181 0.323847341008746 1686 729761 SGTC_3034 9090421 49.47 µM 0.456842336279576 0.351752627583326 no 1182 0.323892186655975 1569 17173761 SGTC_2072 5231554 129 µM 0.456457953121132 0.351874517933968 no 1183 0.324030350001465 1652 789545 SGTC_512 prima-1 270 µM 0.456305547844321 0.351922850834864 no 1184 0.324085137529768 1606 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2367 9070478 135.38 µM 0.452858419693312 0.353016690280346 no 1185 0.325325346820724 1549 572802 SGTC_2412 st077135 33.4 µM 0.451516815262973 0.353442736103051 no 1186 0.325808554287477 1639 13258915 SGTC_133 0724-0033 378.92 µM 0.451185622229978 0.353547939515996 no 1187 0.325927885614921 1474 280309 SGTC_2653 dihydrofissinolide 100 µM 0.450004552241871 0.353923197245933 no 1188 0.326353579083667 1574 6857746 SGTC_1661 st013063 9.66 µM 0.449901800099356 0.353955851084659 no 1189 0.326390624782012 1569 721395 SGTC_2830 7992007 71.43 µM 0.447607551247413 0.354685225044844 no 1190 0.327218226220049 1552 1952075 SGTC_26 0302-0163 425.158 µM 0.447500214638176 0.354719361935249 no 1191 0.327256966465918 1579 3100915 SGTC_1004 4084-0029 199 µM 0.446130239542587 0.355155165526568 no 1192 0.327751585244156 1670 716894 YLR208W SEC13 SGTC_2696 st077691 74.316 µM 0.445619837517972 0.355317578308214 no 1193 0.327935939255134 1571 757133 SGTC_2376 9072922 81.32 µM 0.443907851235389 0.355862533700357 no 1194 0.328554603972807 1594 17087968 SGTC_950 1165-0508 94.1 µM 0.442088910556912 0.356441857416093 no 1195 0.329212434367371 1522 6148369 SGTC_3014 9081533 49.47 µM 0.441996917973547 0.356471165419827 no 1196 0.329245718089606 1665 21367265 SGTC_3056 9094900 49.47 µM 0.441801062951541 0.35653356587883 no 1197 0.329316584659275 1483 25236784 SGTC_2744 captopril 92.04 µM 0.435719630544615 0.358473046341297 no 1198 0.331520080599763 1673 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_58 0957-0393 9 µM 0.432557753130359 0.359482875135514 no 1199 0.332668043403546 1543 6997992 SGTC_1373 2887-0003 58.5 µM 0.432091621084545 0.359631829909931 no 1200 0.332837412120589 1567 776948 SGTC_1520 flindersine 88 µM 0.427300565905471 0.361164067508545 no 1201 0.334580210343613 1744 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1925 st057770 10.1 µM 0.427210129874212 0.361193011570829 no 1202 0.334613141877127 1491 5989122 SGTC_237 nikkomycin 200 µM 0.427058655219366 0.361241492831798 no 1203 0.334668302971218 1659 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2388 9080168 200 µM 0.426376687617315 0.361459792250432 no 1204 0.334916692853527 1517 15943073 SGTC_1380 2291-0730 164 µM 0.425449075484488 0.361756795452479 no 1205 0.335254668631871 1559 2999191 SGTC_988 1497-1057 103 µM 0.424882448409819 0.36193825931402 no 1206 0.335461185039273 1676 3533044 SGTC_2746 daunorubicin 9.88 µM 0.424384043974081 0.362097900353034 no 1207 0.335642877708446 1647 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1906 st060206 94.7 µM 0.421036588667834 0.363170724845776 no 1208 0.33686418217778 1697 5133468 SGTC_2157 5649910 96.377 µM 0.419260782360078 0.363740288968487 no 1209 0.337512777353775 1545 2858091 SGTC_2975 9084847 53.72 µM 0.414097616439834 0.365398006759013 no 1210 0.339401309175066 1584 27211724 SGTC_851 0394-0702 453 µM 0.41351714886575 0.365584533252577 no 1211 0.339613880402722 1712 762646 SGTC_914 3820-6779 408 µM 0.413222532787398 0.365679216862409 no 1212 0.339721790368644 1559 2893481 SGTC_3069 9117009 49.47 µM 0.412037442377164 0.366060163411609 no 1213 0.340155989827494 1589 41904981 SGTC_1462 k081-0014 26.5 µM 0.411695258642397 0.366170182741732 no 1214 0.340281400326192 1494 3270634 SGTC_2947 9072639 7.68 µM 0.409030389581842 0.367027370552521 no 1215 0.341258679736719 1538 16488146 SGTC_2293 7624732 200 µM 0.40768578974796 0.367460129639001 no 1216 0.341752185711533 1533 894453 SGTC_1571 st070080 73.4 µM 0.406185347543273 0.367943245323011 no 1217 0.342303209651695 1718 4315245 SGTC_77 0828-0286 12.516 µM 0.405664207215887 0.368111092166229 no 1218 0.342494672415106 1532 745345 SGTC_980 1473-0395 201 µM 0.402930036355137 0.368992115184292 no 1219 0.343499847113868 1583 768876 SGTC_1045 1348-1485 165 µM 0.402553719587183 0.36911342854359 no 1220 0.343638280910458 1583 6810614 SGTC_807 1315-0151 48 µM 0.401817282512697 0.369350871717058 no 1221 0.34390925105658 1753 4011080 SGTC_518 1021-0119 62.6 µM 0.401389823698329 0.369488716514809 no 1222 0.344066570230493 1563 1097762 SGTC_383 2324-0395 7.37 µM 0.400612625480161 0.369739386514712 no 1223 0.344352674373087 1687 3146421 SGTC_378 3970-0959 8.33 µM 0.400529192504699 0.369766299472681 no 1224 0.344383393225783 1652 6615653 SGTC_2323 6148992 148.28 µM 0.400323124861561 0.369832773403872 no 1225 0.344459268843506 1579 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1220 1838-0075 193 µM 0.398421303671132 0.370446452075167 no 1226 0.345159828471855 1660 5529645 SGTC_664 1222-0054 14.9 µM 0.397980734457494 0.37058866183208 no 1227 0.345322193488926 1628 6813991 SGTC_605 1315-0399 119 µM 0.396823675484046 0.370962228913992 no 1228 0.345748745309064 1689 24020461 SGTC_1395 3486-0190 4.35 µM 0.39639043337496 0.371102136415455 no 1229 0.345908511205661 1763 6748079 SGTC_179 1273-0063 6.77 µM 0.395111819400408 0.37151514035741 no 1230 0.346380183225191 1577 3108139 SGTC_1473 k844-0725 134 µM 0.394824359238269 0.371608012992019 no 1231 0.346486258168035 1689 54682906 SGTC_316 k060-0003 58.6 µM 0.394787754123644 0.371619839909703 no 1232 0.346499766592565 1701 6152314 SGTC_2849 9019321 12.99 µM 0.394664626881782 0.371659622555421 no 1233 0.346545205802664 1657 16489627 SGTC_2044 5102272 200 µM 0.393868307584663 0.371916947914353 no 1234 0.346839134923692 1621 592666 SGTC_2730 imipramine 71.33 µM 0.392613136942801 0.372322664223516 no 1235 0.347302617637971 1690 3696 A tricyclic antidepressant. SGTC_671 0560-0003 407 µM 0.390259920206835 0.373083690231059 no 1236 0.348172178639568 1700 3238678 SGTC_1200 1643-0193 18.4 µM 0.388754924118669 0.373570663194305 no 1237 0.348728724150895 1680 5403974 SGTC_1019 4262-0212 3.4 µM 0.388353320362557 0.37370064465593 no 1238 0.348877291774045 1743 4677213 SGTC_614 0462-0418 107 µM 0.387554217218795 0.373959321897561 no 1239 0.349172977575604 1584 5188303 SGTC_1105 epirubicin 18.1 µM 0.386873149714951 0.374179834705846 no 1240 0.34942505988477 1597 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2495 cafestol 54.53 µM 0.386344378785075 0.374351066047583 no 1241 0.349620818745983 1691 16667697 An anti-infammatory. SGTC_224 benfluorex 43.875 µM 0.385926607007065 0.374486370179153 no 1242 0.349775512355673 1747 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_202 3594-0513 34.79 µM 0.385337346303488 0.374677240861172 no 1243 0.34999374772369 1673 708429 SGTC_2886 9058944 51.95 µM 0.383995548937667 0.375111984349156 no 1244 0.350490873257278 1627 4949929 SGTC_1705 st027868 56.3335 µM 0.382028543866811 0.375749582394506 no 1245 0.351220096277707 1754 292948 SGTC_1266 0828-0227 32.9 µM 0.379167754491712 0.376677503034817 no 1246 0.352281647538222 1700 3913820 SGTC_3223 9129970 49.47 µM 0.378289246648524 0.37696259763848 no 1247 0.352607866440759 1672 17248386 SGTC_888 0916-0002 6.97 µM 0.377448009962672 0.377235659842629 no 1248 0.352920346965247 1743 2802138 YIL048W NEO1 SGTC_2199 6590217 200 µM 0.377430812773369 0.377241242625191 no 1249 0.352926735961468 1716 703109 SGTC_741 4582-0002 126 µM 0.376772619969839 0.377454933285679 no 1250 0.353171294940278 1622 2912688 SGTC_537 1334-0398 209 µM 0.37643133751393 0.37756574974926 no 1251 0.353298126180837 1783 5846986 SGTC_1623 st003709 20.3 µM 0.375210935733516 0.377962103946827 no 1252 0.353751798903028 1614 16192618 SGTC_2382 9035899 200 µM 0.374564803542406 0.378172002633426 no 1253 0.353992076547698 1653 6462679 SGTC_68 0986-0284 82.829 µM 0.374106247344812 0.378320988312062 no 1254 0.354162635460898 1571 423278 YIL048W NEO1 SGTC_2748 diazoxide 86.69 µM 0.373399504731212 0.378550645597533 no 1255 0.354425564028186 1713 3019 A potassium channel activatior. SGTC_1149 3909-7961 23.3 µM 0.371150581303088 0.379281722410903 no 1256 0.355262689391089 1620 735261 SGTC_2990 9074105 71.4286 µM 0.370641139122549 0.379447391242931 no 1257 0.355452418241804 1674 6502001 SGTC_3167 9103034 49.47 µM 0.3701339613571 0.379612345685218 no 1258 0.355641339357977 1676 5127859 SGTC_415 dibenzyl ketone 100 µM 0.369207384806411 0.379913761909734 no 1259 0.355986575930148 1779 7593 SGTC_2474 5321570 43.32 µM 0.367143390957721 0.380585443100053 no 1260 0.356756031260634 1762 2841384 SGTC_91 0417-1751 58.384 µM 0.366056091780828 0.380939425553373 no 1261 0.357161610319104 1685 6795624 SGTC_757 1066-0008 322 µM 0.365247402606986 0.3812027680426 no 1262 0.357463368350589 1736 6842497 SGTC_2889 9059656 51.95 µM 0.36339155367877 0.381807316697183 no 1263 0.358156205179159 1740 3949838 SGTC_3310 9130229 44.1445 µM 0.362589219254561 0.382068769044917 no 1264 0.358455882393113 1763 7761258 SGTC_3233 9132340 49.47 µM 0.362207100875479 0.382193306795954 no 1265 0.358598636797482 1612 17682950 SGTC_2180 6301957 200 µM 0.360550760997404 0.38273327201534 no 1266 0.359217651828925 1778 845462 SGTC_2897 9048598 12.99 µM 0.359480602868131 0.383082263866818 no 1267 0.359617793027216 1672 6467404 SGTC_1165 k072-0275 30.3 µM 0.359245501424849 0.383158946093011 no 1268 0.359705720091662 1723 6153523 YGL055W OLE1 SGTC_650 1328-0195 38 µM 0.35851948112185 0.383395778517608 no 1269 0.359977295841772 1790 2780821 SGTC_2851 9015922 71.43 µM 0.357968214611175 0.38357563425964 no 1270 0.36018355027226 1769 2996893 SGTC_2584 androsterone 48.74 µM 0.357851348949724 0.383613765975116 no 1271 0.360227280380594 1718 2754130 A steroid. SGTC_2669 eugenol 100 µM 0.35609946914001 0.384185516027783 no 1272 0.360883037385691 1795 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_3143 9086658 49.47 µM 0.355848489337662 0.384267447410742 no 1273 0.360977016746727 1679 25236626 SGTC_3111 9122088 49.47 µM 0.354962108509015 0.38455684435307 no 1274 0.361308989090106 1783 16876704 SGTC_1790 st045711 43.5 µM 0.353370042969065 0.385076803748093 no 1275 0.361905520623217 1813 585119 SGTC_334 1502-1024 68.5 µM 0.352428349747999 0.385384452660442 no 1276 0.362258522038748 1718 3296216 SGTC_196 k015-0023 18.111 µM 0.351292221981869 0.385755718876034 no 1277 0.362684564771315 1685 5211998 SGTC_100 0086-0128 49.5915 µM 0.351058377162067 0.38583214817858 no 1278 0.36277227663372 1611 93297 SGTC_1255 0566-0045 221 µM 0.350455551814972 0.386029194660264 no 1279 0.362998421036198 1756 2788469 SGTC_76 0433-0009 400.328 µM 0.348199990271981 0.386766734123058 no 1280 0.363844997542529 1693 2841569 SGTC_2710 st078562 53.7235 µM 0.348194272849034 0.386768604167406 no 1281 0.363847144300998 1651 17250908 SGTC_203 k066-0004 30.888 µM 0.347779406641647 0.386904304869462 no 1282 0.3640029282518 1860 6795412 SGTC_2372 9071633 200 µM 0.347310564733302 0.38705767739978 no 1283 0.364179007352418 1786 21321366 SGTC_625 k213-0058 121 µM 0.343675502252403 0.388247414251871 no 1284 0.365545168279744 1770 3655420 SGTC_303 1348-1668 34.2 µM 0.342145518655704 0.388748484312162 no 1285 0.366120691666637 1745 5380509 SGTC_984 1492-0255 2.91 µM 0.341389423554214 0.388996174079747 no 1286 0.366405218084806 1741 1585198 SGTC_2953 9074162 66.49 µM 0.34032853175549 0.389343788481021 no 1287 0.366804566460096 1879 16451992 SGTC_1932 st074806 40.9 µM 0.338946733684675 0.389796684588921 no 1288 0.36732492882036 1776 17251235 SGTC_579 4491-1009 110 µM 0.33884672790556 0.389829468151717 no 1289 0.367362598817463 1900 1271041 SGTC_1092 toremifene 6.32 µM 0.338425215243337 0.389967655645804 no 1290 0.367521387474571 1744 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_519 k048-0011 62.8 µM 0.338320494828818 0.390001989041583 no 1291 0.367560840370487 1756 6836379 SGTC_403 arphamenine a 50 µM 0.337199557067803 0.390369550838644 no 1292 0.36798323558516 1758 5487158 An arginine aminopeptidase inhibitor. SGTC_1992 st073643 23.3 µM 0.334957381750661 0.391105066536058 no 1293 0.36882861768095 1716 3161292 SGTC_3229 9132204 49.47 µM 0.334400321740072 0.391287863169699 no 1294 0.369038748327031 1776 17682924 SGTC_1355 1499-0035 1.68 µM 0.333330199915617 0.391639085978276 no 1295 0.369442522681673 1691 1548538 SGTC_90 0870-0863 4.608 µM 0.331380967086434 0.392279067108647 no 1296 0.370178369788782 1687 1738164 SGTC_287 k060-0039 29.6 µM 0.331218233179253 0.392332509863333 no 1297 0.370239824355478 1830 5861974 SGTC_2593 nobiletin 86.24 µM 0.330718813414212 0.392496534872595 no 1298 0.370428445095125 1671 72344 An anti-infammatory. SGTC_897 1000-0139 31.4 µM 0.330311713499199 0.392630253297373 no 1299 0.370582221547169 1845 6151020 SGTC_1332 1480-0653 17.5 µM 0.328941188995469 0.393080516887975 no 1300 0.37110007039149 1854 5749438 SGTC_1768 st044301 37.178 µM 0.326210483831601 0.39397807176043 no 1301 0.372132554962864 1694 3931349 SGTC_2321 7390090 138.78 µM 0.325077058354348 0.394350782871821 no 1302 0.372561375802386 1674 649046 SGTC_157 1348-1695 65.819 µM 0.324496047620731 0.394541877654962 no 1303 0.372781257031472 1725 5380510 SGTC_2315 7733312 200 µM 0.324382303851894 0.394579291021752 no 1304 0.372824307768621 1693 726316 SGTC_787 4152-0075 138 µM 0.324227601068917 0.394630178464071 no 1305 0.372882863581267 1756 9566539 SGTC_1835 st008666 49.2 µM 0.324186321718595 0.394643757066444 no 1306 0.372898488527781 1695 690455 SGTC_453 enantio-paf c16 10 µM 0.323633429087123 0.394825640216451 no 1307 0.373107788077463 1746 13871343 A lipid and platelet activating factor SGTC_1957 st077035 62.4 µM 0.32339161666793 0.394905195607984 no 1308 0.373199338838755 1774 705593 SGTC_2709 st078560 56 µM 0.32154472258102 0.395512961246472 no 1309 0.373898813181831 1869 17250903 SGTC_1616 st002734 56.1 µM 0.320192736141895 0.395958026667581 no 1310 0.374411114648604 1781 4026101 SGTC_2426 5582046 32.21 µM 0.319962614720791 0.396033794717239 no 1311 0.374498335523487 1783 2251934 SGTC_1237 0330-0133 46.1 µM 0.319947062887211 0.396038915338813 no 1312 0.374504230228332 1741 X1237 YHR072W ERG7 SGTC_3234 9132280 49.47 µM 0.318660474904301 0.396462601403965 no 1313 0.374991994858944 1760 17612295 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.318476121094536 0.396523320953685 no 1314 0.375061902529243 1898 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1670 st016595 4.04 µM 0.312198850068019 0.398592317777884 no 1315 0.377444702988308 1831 597879 SGTC_3151 9099821 49.47 µM 0.312155601411704 0.398606582555796 no 1316 0.37746113613314 1710 17174189 SGTC_1290 0986-0249 10.2 µM 0.310425561502966 0.399177315460145 no 1317 0.378118679156696 1839 53329 SGTC_1852 st056254 31.4 µM 0.310255076923645 0.399233569295988 no 1318 0.378183495044639 1802 442583 SGTC_727 3032-0951 202 µM 0.308741085951816 0.399733224039424 no 1319 0.378759243767272 1787 3652836 SGTC_1185 1319-0113 81.3 µM 0.307748581294511 0.400060864481052 no 1320 0.379136824986558 1818 4672763 SGTC_354 2783-3500 4.88 µM 0.304213413715697 0.401228445619126 no 1321 0.380482653089125 1699 6740761 SGTC_768 0384-0033 77.3 µM 0.304001728275973 0.401298388357267 no 1322 0.380563287230947 1710 3965305 YMR134W ERG29 SGTC_2448 5185112 27.17 µM 0.303335003738327 0.401518700689434 no 1323 0.380817286448192 1768 5718189 SGTC_2512 diallyl trisulfide 49.23 µM 0.303150319730631 0.401579733178889 no 1324 0.380887653821451 1808 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2879 9041815 71.43 µM 0.302763402856493 0.401707605308048 no 1325 0.381035087716428 1833 4942971 SGTC_3039 9090270 49.47 µM 0.30234285649773 0.401846603579279 no 1326 0.381195355647205 1916 17173750 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.302285622768958 0.401865521334811 no 1327 0.381217168686098 1823 66535 A nucleotide analog. SGTC_492 tmb-8 126 µM 0.302182740559547 0.401899528093007 no 1328 0.381256380318667 1888 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3121 9125696 49.47 µM 0.300401567386785 0.402488395861468 no 1329 0.381935434131569 1890 1235365 SGTC_2694 st077685 81.9 µM 0.29953338993768 0.402775501451227 no 1330 0.382266549653157 1731 2838096 SGTC_3159 9100096 49.47 µM 0.298923318711411 0.402977282898716 no 1331 0.382499277181584 1764 25236875 SGTC_1694 st024011 44.9 µM 0.298402969537654 0.403149409142676 no 1332 0.382697811444408 1799 2787533 SGTC_3251 9135047 49.47 µM 0.295905050825586 0.403975956119386 no 1333 0.383651296856727 1896 17682963 SGTC_1508 1080-0625 72.9 µM 0.295755038044465 0.404025608177657 no 1334 0.383708581023061 1804 767111 SGTC_1393 3470-5649 58.2 µM 0.295510052690332 0.404106698106614 no 1335 0.383802137061025 1784 4108395 SGTC_2066 5222451 176 µM 0.294000054351458 0.404606597025058 no 1336 0.384378930919875 1785 2281147 SGTC_2583 asiatic acid 100 µM 0.293612397633766 0.404734959525855 no 1337 0.384527050602247 1815 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2281 7943571 200 µM 0.293387243020257 0.404809518363292 no 1338 0.384613087627514 1961 1244024 SGTC_2121 5257820 149.641 µM 0.292132785046284 0.405224989117921 no 1339 0.38509255030691 1919 791256 SGTC_1324 1418-0026 34.4 µM 0.291841826994258 0.40532136837603 no 1340 0.385203781657939 1833 1372513 SGTC_1235 benzylparaben 21.5 µM 0.290245072937327 0.405850391948165 no 1341 0.385814378163825 1817 7180 SGTC_1339 1486-1321 22.7 µM 0.283896679847088 0.407955382048785 no 1342 0.388244780480626 1784 3469382 SGTC_2909 7941780 10.49 µM 0.283827954630463 0.407978184507503 no 1343 0.388271115214439 1958 1243215 SGTC_2218 6965428 192.983 µM 0.282893052525898 0.408288408224803 no 1344 0.388629410214147 1885 675684 SGTC_269 exalamide 29 µM 0.282587300763997 0.408389876730972 no 1345 0.388746608118563 1827 3316 A derivative of salicylamide. SGTC_2523 spermine 47.74 µM 0.282118589776873 0.408545437729066 no 1346 0.388926289685538 1943 1103 A DNA binding polyamine. SGTC_3243 9134147 49.47 µM 0.280690596136779 0.40901946482397 no 1347 0.389473861053295 1923 24282180 SGTC_566 0958-0068 16.5 µM 0.279488273190361 0.409418683039889 no 1348 0.38993506812374 1861 6815365 SGTC_3265 9137266 49.47 µM 0.278665763100998 0.409691842687094 no 1349 0.390250669578681 1989 17224265 SGTC_3013 9080133 71.4286 µM 0.278600433588103 0.409713540820832 no 1350 0.390275739960888 1855 17050193 SGTC_293 4049-0273 38.5 µM 0.277674694368964 0.410021039716979 no 1351 0.390631043959015 1840 1380311 SGTC_1831 st055328 12 µM 0.277458584573276 0.410092831971721 no 1352 0.390714001293828 1915 1103068 SGTC_583 1488-1091 88.9 µM 0.276993565630158 0.410247322730111 no 1353 0.390892523402698 1966 4303273 SGTC_973 1325-0077 65.9 µM 0.276558299302771 0.41039194155847 no 1354 0.391059644234033 1917 2835149 SGTC_1320 1313-0481 95.3 µM 0.276511621129636 0.410407451275943 no 1355 0.391077567548425 1949 6813365 YLR208W SEC13 SGTC_1000 4048-0884 8.67 µM 0.275002315074533 0.410909022516552 no 1356 0.391657229843668 1835 13040088 SGTC_1018 4259-0013 28.1 µM 0.274108397869728 0.411206157038962 no 1357 0.392000660175632 1838 6801262 SGTC_1414 3917-0015 5.4 µM 0.273320727479403 0.411468017771988 no 1358 0.392303341745366 1897 6618702 SGTC_1837 st055472 66.5 µM 0.2729554475208 0.411589468354579 no 1359 0.392443731613358 1870 676091 SGTC_1600 coumarin 106 71.1 µM 0.272586148387021 0.411712263869614 no 1360 0.392585680421094 1858 100336 A hepatotoxic, DNA x-linker. SGTC_1391 3442-0225 151 µM 0.272549178907732 0.411724557053513 no 1361 0.392599891297127 1822 5227075 SGTC_1379 2144-0755 36.5 µM 0.270615403871688 0.412367701297802 no 1362 0.393343423591579 1957 5392327 SGTC_590 k048-0076 22.4 µM 0.267957851542723 0.413251946599453 no 1363 0.394365881120965 1939 6832814 SGTC_2455 5377712 9.75 µM 0.26757830661532 0.413378268314288 no 1364 0.394511965525036 1746 2243908 SGTC_2487 5918373 44.05 µM 0.265667827904526 0.414014257662393 no 1365 0.395247521409749 1976 2876279 SGTC_2214 7179297 48.276 µM 0.265395128636899 0.41410505639749 no 1366 0.395352544221901 1891 769744 SGTC_1838 st055369 84.5 µM 0.265351530308503 0.414119573448566 no 1367 0.395369335654212 1871 676036 SGTC_1223 0764-0573 147 µM 0.265341172153444 0.414123022448188 no 1368 0.395373325015985 1834 1609797 SGTC_2910 7948405 25.97 µM 0.264651505784909 0.414352678525714 no 1369 0.395638969230837 1961 2971328 SGTC_3311 9131146 2.8755 µM 0.264474335992804 0.414411680072151 no 1370 0.395707218945017 1840 4900406 YPR165W RHO1 SGTC_2492 derrusnin 100 µM 0.264446416180363 0.414420978177131 no 1371 0.395717974564726 1824 1715307 Part of coumarin class of compounds. SGTC_1840 st055363 71 µM 0.263198780804281 0.414836525718165 no 1372 0.396198685231315 1765 676033 SGTC_3079 9117512 49.47 µM 0.2621317394743 0.415191998779727 no 1373 0.396609938762491 1883 7185044 SGTC_1311 1190-0148 100 µM 0.25949911962178 0.416069323479118 no 1374 0.397625080601431 1934 1961333 SGTC_2084 5306078 60.6385 µM 0.258900166718802 0.416268984055764 no 1375 0.397856134773531 1898 679340 SGTC_934 2950-0684 338 µM 0.257587399388889 0.416706669740992 no 1376 0.398362677728581 1964 1121253 SGTC_253 dyclonine 31.25 µM 0.257297951963182 0.41680318742452 no 1377 0.398474386672599 1902 3180 An oral anasthetic. SGTC_1784 st039334 36.3 µM 0.25688112339069 0.416942189795038 no 1378 0.398635271537606 1964 3496984 SGTC_2103 5378138 10 µM 0.256750605122633 0.416985716654802 no 1379 0.398685651698984 1894 244142 SGTC_212 3807-4682 38.772 µM 0.256708139238532 0.416999878926865 no 1380 0.398702043930064 1931 3125501 YBL034C STU1 SGTC_3092 9117248 49.47 µM 0.254185337169346 0.417841420095549 no 1381 0.399676188961886 1937 17141857 SGTC_2045 5106652 78.05 µM 0.254086103891752 0.417874529454563 no 1382 0.399714519326883 1941 673349 SGTC_3288 9119690 36.221 µM 0.253475530985873 0.418078260988212 no 1383 0.399950383666351 1792 17595618 YKL019W RAM2 SGTC_1611 st001856 99.4 µM 0.253361242920154 0.41811639824438 no 1384 0.399994537209674 1807 647478 SGTC_538 2922-0838 53.3 µM 0.252816243568864 0.418298271910168 no 1385 0.400205107412704 1986 777039 SGTC_1372 2752-0194 270 µM 0.252204601942938 0.418502405809148 no 1386 0.400441460596503 1852 823334 SGTC_1366 1683-0113 21.9 µM 0.251350806458634 0.418787394661789 no 1387 0.400771448869532 1823 708623 SGTC_2597 laccaic acid a 100 µM 0.250176121924394 0.419179562881322 no 1388 0.401225575083827 1850 5491415 A textile dye. SGTC_2325 6158266 200 µM 0.24971279643021 0.419334266120258 no 1389 0.401404730765948 1855 3623240 SGTC_2473 5854593 8.94 µM 0.249562462208913 0.419384465026478 no 1390 0.40146286547866 1849 2872951 SGTC_2587 piperic acid 92.2 µM 0.248265378171672 0.419817635730537 no 1391 0.401964542388693 1822 5370536 SGTC_161 4065-0411 162.148 µM 0.247957152261956 0.419920584335646 no 1392 0.402083779596307 1877 1906281 YLR208W SEC13 SGTC_3241 9133421 49.47 µM 0.245935930994437 0.420595815267948 no 1393 0.402865914475398 1917 17018221 SGTC_159 3970-0959 50 µM 0.2431741876171 0.421518810453219 no 1394 0.403935231038424 1960 6615653 SGTC_2178 5812956 200 µM 0.242340918612162 0.421797380099388 no 1395 0.404258005026154 1920 5403383 SGTC_3208 9114115 49.47 µM 0.241634479522772 0.422033579975545 no 1396 0.404531701411076 1748 650895 SGTC_797 k781-0471 270 µM 0.241380079020045 0.422118646364986 no 1397 0.404630275495231 1930 23738129 SGTC_2797 7859098 81.82 µM 0.241097062676109 0.422213285583014 no 1398 0.404739944643236 1856 972681 SGTC_3127 9126946 49.47 µM 0.240309113967826 0.42247679524448 no 1399 0.405045315038585 1797 27243249 SGTC_3290 9121031 71.43 µM 0.239785883203497 0.422651795814854 no 1400 0.405248125661989 1838 17014854 SGTC_924 2046-0044 21.3 µM 0.239349836334791 0.422797648389482 no 1401 0.405417162186716 1881 3623589 SGTC_1597 7-benzyloxygramine 47.5 µM 0.237608254190849 0.423380292595395 no 1402 0.406092473964524 1845 260807 SGTC_1336 1486-0901 104 µM 0.231983036873631 0.425263340828415 no 1403 0.408275594529241 1915 5006114 SGTC_2122 5258151 111.688 µM 0.231316616523089 0.425486539716376 no 1404 0.408534419296025 1883 2173356 SGTC_3016 9080866 49.47 µM 0.231127723830569 0.425549808396148 no 1405 0.408607788824701 1891 17066299 SGTC_1478 0453-0656 35.7 µM 0.228585172399504 0.426401609436141 no 1406 0.409595675089537 1974 5258496 SGTC_2847 9005661 71.43 µM 0.227011875011953 0.426928864977904 no 1407 0.410207254145048 2007 2991449 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.226327970002567 0.42715810126785 no 1408 0.410473172906547 1907 5106787 A p450 inhibitor. SGTC_555 4296-0685 37 µM 0.223340945557034 0.428159601354875 no 1409 0.411635081009771 1939 2908540 YHR072W ERG7 SGTC_2798 7813637 45.45 µM 0.222553795396829 0.428423597168142 no 1410 0.411941400213671 1938 956368 SGTC_476 mead acid 10 µM 0.222501312113505 0.428441200244972 no 1411 0.411961825975044 1910 5312531 An omega 9 fatty acid. SGTC_32 0928-0142 34.1 µM 0.221723776615784 0.428702005031548 no 1412 0.412264459852876 2001 2244242 SGTC_839 0122-0028 230 µM 0.219428560075357 0.429472059066025 no 1413 0.413158112182167 1936 759448 SGTC_2777 climbazole 1.536 µM 0.21886457927932 0.429661318003897 no 1414 0.413377769579136 1983 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2456 5770359 74.46 µM 0.218543712551548 0.429769000689727 no 1415 0.41350275180944 2010 3118787 SGTC_2531 methyl deoxycholate 70.07 µM 0.218020677801728 0.429944542041986 no 1416 0.413706500189748 1884 16667744 Haematoxylin. SGTC_564 3555-0129 330 µM 0.217794354286527 0.430020505220995 no 1417 0.41379467180431 2040 563260 SGTC_3097 9117246 49.47 µM 0.217699172142658 0.430052452910522 no 1418 0.413831754372527 1940 16423892 SGTC_2961 9083290 32.55 µM 0.217057330288325 0.430267897746071 no 1419 0.414081833340261 1990 17741490 SGTC_2754 granisetron 64.02 µM 0.215156702707686 0.430905996358166 no 1420 0.41482257328967 2034 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_3050 9093513 49.47 µM 0.214255633836084 0.431208575787699 no 1421 0.415173856849096 1939 25236664 SGTC_688 0527-0193 473 µM 0.211181135600061 0.43224129688318 no 1422 0.416372965209762 1948 4007154 SGTC_1997 st073024 93.8 µM 0.20683062615996 0.433703418713601 no 1423 0.418071068530301 2053 686268 SGTC_2296 7971656 126.45 µM 0.206828932344339 0.433703988150232 no 1424 0.418071729964969 1902 666570 SGTC_2174 5790901 200 µM 0.204597071175259 0.434454427114452 no 1425 0.418943471931185 1932 786020 SGTC_3289 9119912 71.43 µM 0.204454506892096 0.434502370854647 no 1426 0.418999169643508 1953 17014829 SGTC_1758 st042942 75.2445 µM 0.202292523727613 0.435229553934068 no 1427 0.419844022178974 2075 669317 SGTC_547 1120-0019 610 nM 0.201516975853862 0.435490463000733 no 1428 0.42014717844203 1927 3676939 SGTC_2634 4'-methoxyflavone 100 µM 0.201234166651117 0.435585612393277 no 1429 0.420257738388768 1909 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_849 0386-0493 241 µM 0.200348223036938 0.43588370671098 no 1430 0.420604125230826 1946 726119 SGTC_279 1273-0055 2.93 µM 0.199538675805164 0.436156127719643 no 1431 0.42092069633287 2069 2847562 SGTC_1904 st060225 78 µM 0.198670395915209 0.436448346537684 no 1432 0.421260291507405 1978 66595 SGTC_296 1222-0039 74.9 µM 0.195862084333208 0.437393718013964 no 1433 0.422359057371787 1936 5984176 SGTC_999 SEC7.066 22.7 µM 0.195310609724041 0.437579404955826 no 1434 0.422574895828671 1975 740511 YDR170C SEC7 SGTC_1767 st044992 70.3 µM 0.19438917983379 0.437889690147049 no 1435 0.422935580786395 1923 9600693 SGTC_554 4483-2211 187 µM 0.194073971951315 0.437995843014974 no 1436 0.423058980757313 1967 747107 SGTC_319 1348-1596 45.5 µM 0.193740030932513 0.438108309527102 no 1437 0.423189722753532 2070 5380505 SGTC_2441 5730946 39.09 µM 0.192704775370268 0.438457000380792 no 1438 0.423595091675345 2016 1774275 SGTC_1898 st060199 18.6 µM 0.192068475284673 0.438671340288556 no 1439 0.423844284110145 1899 688866 SGTC_2873 9040596 71.43 µM 0.191520048568794 0.438856094180093 no 1440 0.424059087382687 1898 6463863 SGTC_702 1488-0190 94 µM 0.191514683588882 0.438857901599411 no 1441 0.424061188805505 2099 949357 SGTC_792 4534-1957 155 µM 0.190498048480648 0.439200420899244 no 1442 0.424459436137219 1970 1717904 SGTC_3125 9127534 49.47 µM 0.189959904750581 0.43938174787043 no 1443 0.424670274883177 2108 1639235 SGTC_846 0335-0850 148 µM 0.189930394986683 0.439391691522953 no 1444 0.424681837105359 2057 6819598 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.189760925374928 0.439448796987509 no 1445 0.424748238257467 1948 15053 SGTC_2019 4016004 108 µM 0.189329885233731 0.439594048452201 no 1446 0.424917136927549 1913 45595336 SGTC_2396 5342950 42.78 µM 0.189217588784782 0.439631891330479 no 1447 0.424961141406922 1942 1886677 SGTC_443 clozapine 122 µM 0.187941489757312 0.440061963722519 no 1448 0.425461259045883 2101 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2405 ticlatone 3.52 µM 0.18702122865744 0.440372155124439 no 1449 0.425821994269525 1993 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1506 4226-2149 212 µM 0.186228301352969 0.440639455622397 no 1450 0.426132865440758 1993 991114 SGTC_1252 0493-0875 34.8 µM 0.184973281129137 0.441062585627324 no 1451 0.426624996244596 1958 3960963 SGTC_2229 7354935 190 µM 0.183191555536927 0.44166340978242 no 1452 0.427323859977985 2074 318112 SGTC_1498 4478-3555 97.6 µM 0.182795194762912 0.441797086786643 no 1453 0.427479359555519 2097 3437919 SGTC_1812 st052057 4.327 µM 0.181483427376801 0.44223954187085 no 1454 0.427994070098285 2002 3645418 SGTC_2652 actinonin 100 µM 0.18069787802503 0.442504539773979 no 1455 0.428302362230257 2046 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1142 3253-1408 9.78 µM 0.178964189943453 0.443089474501499 no 1456 0.428982909989787 2109 256655 SGTC_1351 1496-0003 46.5 µM 0.177742572754342 0.443501714522978 no 1457 0.429462574665285 2086 3891978 SGTC_1773 st048542 73.5835 µM 0.177591121879614 0.443552826547572 no 1458 0.42952204871182 1920 3237138 SGTC_1383 3049-0032 20.7 µM 0.176732767708187 0.443842523805107 no 1459 0.429859150545313 2088 712864 SGTC_3072 9116419 49.47 µM 0.175738461985016 0.444178142651471 no 1460 0.430249708612912 1977 17170162 SGTC_404 fumagillin 50 µM 0.174827096305257 0.44448580101136 no 1461 0.430607748224946 2000 12015870 A methionine aminopeptidase binder. SGTC_418 lividomycin a 100 µM 0.174548908919685 0.444579718038796 no 1462 0.430717048449536 2107 72394 An antibiotic. SGTC_2027 5150920 200 µM 0.174299910193353 0.444663783512603 no 1463 0.430814884909447 2055 786715 SGTC_2282 7944268 200 µM 0.174156294258869 0.444712271405068 no 1464 0.43087131634465 2059 2970414 SGTC_3139 9095020 49.47 µM 0.173673663218318 0.444875224297863 no 1465 0.431060968326478 2110 25236292 SGTC_2216 7189485 200 µM 0.173143180974744 0.445054344154358 no 1466 0.431269441986281 2097 731273 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.17251866383313 0.445265229717681 no 1467 0.431514894859139 2062 4620898 SGTC_2101 5377231 179.231 µM 0.170072430680131 0.446091416919503 no 1468 0.432476587379663 2058 2844213 SGTC_643 k048-0106 28.4 µM 0.168658709295105 0.446568992083669 no 1469 0.433032549311789 2051 6763920 SGTC_1230 0170-0365 3.77 µM 0.168022971879005 0.446783778518127 no 1470 0.433282603523563 2107 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_729 4092-0585 94.1 µM 0.167866716718464 0.446836572343002 no 1471 0.433344067364274 1953 2169061 SGTC_1826 st055655 41.6 µM 0.167538321110776 0.446947530213528 no 1472 0.433473248864967 1981 676168 SGTC_805 3852-0218 479 µM 0.167172733196475 0.447071059455905 no 1473 0.433617069122311 1933 6615355 SGTC_1127 asiatic acid 681.4 nM 0.165232246740682 0.447726820044068 no 1474 0.434380592429857 1916 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2401 5128683 200 µM 0.163360256164326 0.448359568841819 no 1475 0.435117396728131 1978 708373 SGTC_3026 9090633 49.47 µM 0.162513813336465 0.448645716979837 no 1476 0.435450625700679 2025 25236842 SGTC_1546 5-methoxyflavanone 78.7 µM 0.162208300952353 0.448749004949109 no 1477 0.435570911578116 2134 147795 SGTC_2205 7238770 200 µM 0.161432438883543 0.449011324863545 no 1478 0.435876409594115 2124 279867 SGTC_633 0437-0093 97.7 µM 0.160964086318684 0.449169686234708 no 1479 0.436060843353994 2057 2831118 SGTC_2760 etidronate 98.04 µM 0.160730456743272 0.44924868509403 no 1480 0.43615285014524 2017 3305 A chelator and antioxidant. SGTC_1637 st007924 17.4 µM 0.160634524363563 0.449281123986753 no 1481 0.436190630739834 2056 683336 SGTC_775 4577-0580 57.3 µM 0.158842836506944 0.449887033310998 no 1482 0.43689634929056 2075 2006902 SGTC_406 estrone 100 µM 0.156719772884407 0.450605157763585 no 1483 0.437732851568065 2152 5870 A steroid. SGTC_497 capsazepine 133 µM 0.155718398396884 0.450943928103601 no 1484 0.438127497128784 1940 2733484 A calcium channel blocker. SGTC_795 0685-0265 78 µM 0.154973666512651 0.45119589806573 no 1485 0.438421038772563 2166 302754 SGTC_2284 7945075 39.21 µM 0.154723246263785 0.451280628793784 no 1486 0.438519751406736 2153 1245402 SGTC_228 caffeine 993.056 µM 0.154329667118479 0.451413802411744 no 1487 0.438674903274129 2145 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1436 4092-1007 8.32 µM 0.153868532458543 0.45156984144336 no 1488 0.438856698022812 2075 2881121 SGTC_2918 7977171 22.06 µM 0.153603792369417 0.451659427741253 no 1489 0.438961073276015 2072 2236483 SGTC_694 1315-0438 43.2 µM 0.153591895185321 0.451663453727621 no 1490 0.438965763906755 2070 6793154 SGTC_1915 st067105 30.6 µM 0.152353133395697 0.452082675688574 no 1491 0.439454209803863 2105 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2351 9026858 72.31 µM 0.152341174693791 0.452086723015517 no 1492 0.439458925591001 2048 1409300 SGTC_826 1683-5028 118 µM 0.151499456394984 0.452371608321677 no 1493 0.439790869811114 2039 722377 SGTC_2690 usnic acid 100 µM 0.151093498624245 0.452509016276078 no 1494 0.439950980485219 2119 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.149938636737946 0.452899943181167 no 1495 0.440406514279704 2135 5355888 SGTC_1534 6-azauridine 81.6 µM 0.149691136796135 0.452983729184445 no 1496 0.440504150600262 2100 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_3349 9149703 23.001 µM 0.149386777836236 0.453086766505626 no 1497 0.440624222209339 2133 4910494 SGTC_24 0417-1663 219 µM 0.149351162386146 0.45309882392441 no 1498 0.440638273095379 2015 4329390 SGTC_35 0133-0054 64.071 µM 0.149197869150819 0.453150721016956 no 1499 0.440698750673283 2007 99677 SGTC_3302 9125395 16.351 µM 0.147771133975803 0.453633777382429 no 1500 0.441261695474252 2049 17599668 SGTC_1920 st075728 45.7 µM 0.145471335606803 0.454412574936615 no 1501 0.442169372929804 2174 3400306 SGTC_3336 9143619 71.43 µM 0.144846091027823 0.454624336516074 no 1502 0.442416195274199 2149 45595730 SGTC_640 3381-0960 37.1 µM 0.144403612420526 0.454774205617938 no 1503 0.442590882204681 2136 1745025 SGTC_3093 9117344 49.47 µM 0.14438052561747 0.454782025378388 no 1504 0.442599996992138 2079 24824913 SGTC_452 diindolylmethane 8 µM 0.142392256206674 0.455455540060045 no 1505 0.443385089357277 2097 3071 Inhibits expression of several cancer promoting factors. SGTC_1444 4112-3581 28 µM 0.142247341186969 0.455504634208588 no 1506 0.443442319544224 2061 2877249 SGTC_2211 7117706 200 µM 0.141764220612546 0.455668310161705 no 1507 0.443633123195471 2162 822771 SGTC_2635 hydroquinidine 100 µM 0.141690024706202 0.455693447588413 no 1508 0.443662427287209 2054 442912 An experimental heart treatment. SGTC_2860 9025725 38.96 µM 0.141439142094191 0.455778447435731 no 1509 0.443761517071096 1965 40546248 SGTC_1833 st055984 71 µM 0.139338796914992 0.456490130266359 no 1510 0.444591216695084 2032 676288 SGTC_681 1642-0006 26.6 µM 0.139317313823247 0.456497410341393 no 1511 0.444599704424382 2163 4446530 SGTC_1937 st074714 47.2 µM 0.139125304073362 0.456562478224946 no 1512 0.444675566457001 2078 17250970 SGTC_2979 9012552 45.46 µM 0.137906686141551 0.456975468137 no 1513 0.445157083062882 2199 17100905 SGTC_663 1486-0733 13.9 µM 0.136148382165483 0.457571439567953 no 1514 0.445851990075139 2062 722445 YPR165W RHO1 SGTC_979 1426-2828 121 µM 0.135950442664828 0.457638536520092 no 1515 0.445930229069754 2105 747872 SGTC_307 1501-1223 22.3 µM 0.135733642807031 0.457712028086195 no 1516 0.446015925360964 2094 2830329 SGTC_1999 st074831 12.5 µM 0.134923916792365 0.457986524577995 no 1517 0.446336014794838 2032 17112523 SGTC_693 4161-2696 114 µM 0.132812684714059 0.458702324533267 no 1518 0.447170761142002 2135 805759 SGTC_3319 9138450 16.7555 µM 0.132366839388845 0.458853502791775 no 1519 0.447347071091627 2030 2029690 SGTC_1140 3229-1848 2.98 µM 0.131168502582915 0.459259867025778 no 1520 0.447821005971385 2161 2849525 SGTC_1502 4534-4282 27.7 µM 0.130983291608913 0.459322677146832 no 1521 0.44789426244312 2076 3278949 SGTC_1091 telmisartan 47.6 µM 0.130493672949651 0.459488725148802 no 1522 0.448087929798298 2151 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2224 6650123 117.647 µM 0.129444706414747 0.459844492690312 no 1523 0.448502887309595 2108 2908370 SGTC_2269 7935389 174.42 µM 0.129382023664605 0.459865753195865 no 1524 0.448527685578526 2104 97605 SGTC_164 4100-3994 89.624 µM 0.128289587331726 0.460236300124103 no 1525 0.448959902560068 2183 4615967 SGTC_230 MPP+ 141.667 µM 0.128165207600364 0.460278491073737 no 1526 0.449009116630612 2038 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2783 7738165 71.43 µM 0.128060837797006 0.460313894784561 no 1527 0.449050413858932 2024 17201110 SGTC_902 1120-0002 2.07 µM 0.127523040069417 0.460496328347919 no 1528 0.449263219354794 2172 3280475 SGTC_1779 st039427 55 µM 0.127299261692628 0.460572241657592 no 1529 0.449351772318841 2209 1124498 SGTC_2956 9076196 2.52 µM 0.126608195528077 0.460806684090042 no 1530 0.44962525502648 2204 16423868 SGTC_1893 st059353 36.1 µM 0.12630638798062 0.460909075809081 no 1531 0.449744699940423 2032 3112488 SGTC_2827 7993847 71.43 µM 0.124272096536034 0.461599300102083 no 1532 0.450549919876585 2095 2985692 SGTC_130 0136-0219 337.655 µM 0.122817304076447 0.462092974529242 no 1533 0.451125885664783 2214 234244 SGTC_822 1487-0950 154 µM 0.121687474473697 0.462476415241348 no 1534 0.45157326671704 2210 1958375 SGTC_1720 st037298 9.481 µM 0.121167632334111 0.462652850607016 no 1535 0.451779130420908 2084 597396 SGTC_2799 7812892 81.82 µM 0.119931458759533 0.463072439610669 no 1536 0.452268721920081 2159 20205235 SGTC_377 3970-0964 33.1 µM 0.118361704856068 0.463605313484406 no 1537 0.452890533765887 2131 16481235 SGTC_1402 3909-7673 35.9 µM 0.117513776026307 0.463893181446326 no 1538 0.453226463995031 2179 5328014 SGTC_3119 9125183 49.47 µM 0.116470858195452 0.464247273192145 no 1539 0.453639690339056 2191 22695334 SGTC_1583 clindamycin 39.6 µM 0.115452795736209 0.464592953352791 no 1540 0.454043116874006 2020 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2946 9065502 71.43 µM 0.114268443267235 0.464995130418024 no 1541 0.454512498619058 2224 16489101 SGTC_2233 sulbentine 40.3845 µM 0.114117397930848 0.465046424291318 no 1542 0.454572365382698 2159 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_3101 9120531 49.47 µM 0.11401358522003 0.465081678652945 no 1543 0.454613512110957 2206 24824904 SGTC_96 0929-0093 37.281 µM 0.113856212857064 0.465135122170616 no 1544 0.454675888425022 2065 6991579 SGTC_1912 st060209 90.8 µM 0.113665494885787 0.465199890670694 no 1545 0.454751483145515 2080 688787 SGTC_1108 betulinic acid 729.144 nM 0.112069761825127 0.465741843246267 no 1546 0.455384046461603 2103 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1697 st025554 27.742 µM 0.110865074512266 0.466151028631219 no 1547 0.455861670663733 2198 1269519 SGTC_1743 st037606 46.3785 µM 0.109612019589654 0.466576680572507 no 1548 0.456358538923648 2140 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1816 st051957 91.6 µM 0.109594488576836 0.466582635978548 no 1549 0.456365490903596 2169 674121 SGTC_2679 rapamycin 1 nM 0.108967616142487 0.466795593777677 no 1550 0.456614087961006 2136 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1887 st057648 70.8 µM 0.108277960937654 0.467029890787929 no 1551 0.456887602221616 2201 688672 SGTC_2882 9058044 58.44 µM 0.108132844076729 0.46707919289085 no 1552 0.456945157544169 2051 18076804 SGTC_215 1287-0124 461.5 µM 0.108064877763689 0.467102283986876 no 1553 0.456972114219792 2218 5560863 SGTC_1064 honokiol 6.76 µM 0.107908459339916 0.467155426510874 no 1554 0.457034153362866 2106 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_887 0885-0007 9.62 µM 0.107584877159986 0.467265364099143 no 1555 0.457162496816973 2196 5719458 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.10718692808655 0.467400571387259 no 1556 0.457320342779243 2133 115019 SGTC_892 0929-0076 29 µM 0.105837200341667 0.46785918318301 no 1557 0.457855760464541 2105 5751038 SGTC_1553 gossypol 38.6 µM 0.105590561989577 0.467942990828371 no 1558 0.457953606664143 2209 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2784 7567673 72.73 µM 0.105306524896729 0.468039508315868 no 1559 0.45806629282352 2229 3471247 SGTC_2009 4012297 12.05 µM 0.10521723660569 0.468069849394728 no 1560 0.458101716902801 2089 45595307 SGTC_1302 1159-0335 255 µM 0.104298368938201 0.468382100815442 no 1561 0.458466286127091 2148 649284 SGTC_376 3970-0862 59.1 µM 0.104131741346824 0.46843872662093 no 1562 0.458532400912701 2223 3135186 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.102787503076721 0.468895568427455 no 1563 0.459065811913401 2121 5282362 SGTC_2049 5262831 67.185 µM 0.102560448226319 0.468972737488626 no 1564 0.459155917495038 2142 763417 SGTC_360 0957-0399 1.01 µM 0.101248567958931 0.4694186285599 no 1565 0.45967657155935 2210 6752301 YPR165W RHO1 SGTC_3235 9132602 49.47 µM 0.0987642611699059 0.470263116822244 no 1566 0.460662722584315 2157 4912240 SGTC_2917 7979103 53.79 µM 0.0985298985969184 0.470342790453098 no 1567 0.46075576590651 2193 2980565 SGTC_2865 9030313 51.95 µM 0.0984797099057271 0.470359852697309 no 1568 0.460775691392088 2173 42562754 SGTC_546 peri-Naphthalide 147 µM 0.0978929320097917 0.470559338870986 no 1569 0.461008656234796 2187 223824 A penicillin ester. SGTC_1350 1495-0454 146 µM 0.0977061924213629 0.470622826055857 no 1570 0.46108279912346 2224 1069057 SGTC_1090 efavirenz 20.7 µM 0.0976206713352576 0.470651901516604 no 1571 0.461116754776815 2162 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_739 1486-1183 203 µM 0.095650439919406 0.471321783843626 no 1572 0.461899101776757 2251 4346692 SGTC_1645 Cervolide 78 µM 0.0954485962295509 0.471390415686113 no 1573 0.461979259015921 2159 23173 A fragrance. SGTC_1271 0832-2808 169 µM 0.0953383910510174 0.471427888528915 no 1574 0.462023024934275 2224 3663794 SGTC_2123 5259487 200 µM 0.095316670646003 0.471435274103924 no 1575 0.462031650839747 2217 2173474 SGTC_1299 1079-1439 3.74 µM 0.0948963071855848 0.471578211946186 no 1576 0.462198594861373 2169 323161 SGTC_620 0109-0052 432 µM 0.0927857971176476 0.472295911954465 no 1577 0.463036867294559 2246 493037 SGTC_2446 5162541 200 µM 0.0918558106435938 0.472612191827093 no 1578 0.463406300482909 2199 1549321 SGTC_2701 st077767 14.721 µM 0.0918018130982206 0.472630556429535 no 1579 0.463427751751616 2156 5721188 SGTC_170 4197-0004 226 µM 0.0903638487068187 0.473119630393388 no 1580 0.46399904183963 2183 218692 SGTC_1612 st002233 45.4 µM 0.0893855692837588 0.473452381586633 no 1581 0.464387745802681 2251 1035021 SGTC_3193 9111931 49.47 µM 0.0885473979434862 0.473737491270739 no 1582 0.464720807071354 2192 17087244 SGTC_3065 9113888 49.47 µM 0.0876904128021814 0.474029014505417 no 1583 0.46506136987233 2223 16648368 SGTC_2611 pyromycin 23.93 µM 0.0872126125151696 0.474191555326872 no 1584 0.465251257109882 2162 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2011 4012611 177 µM 0.0853253392219554 0.474833620439311 no 1585 0.46600137360084 2196 2049887 SGTC_793 0488-0545 106 µM 0.0842420909245856 0.475202179602976 no 1586 0.466431976693848 2081 292548 SGTC_1477 0139-0234 16 µM 0.0840901465202255 0.475253878136758 no 1587 0.46649237941712 2257 620880 SGTC_1268 0828-0275 2.46 µM 0.0832125981857639 0.47555246890703 no 1588 0.466841247789555 2218 745337 SGTC_3318 9139014 38.6185 µM 0.083012418645357 0.475620583053955 no 1589 0.466920832523234 2209 16643984 SGTC_386 1509-0011 3.07 µM 0.0824804696508753 0.475801590283209 no 1590 0.46713232418592 2225 3107280 SGTC_1188 1403-0014 4.57 µM 0.0819047422006749 0.475997499711461 no 1591 0.467361231690727 2174 9614867 SGTC_353 1988-1175 58.3 µM 0.0796077654028891 0.476779175819749 no 1592 0.468274609461509 2186 2788357 SGTC_3012 9080433 71.4286 µM 0.0791642395121058 0.476930120944371 no 1593 0.468450994013911 2256 17688859 SGTC_2895 9054447 58.44 µM 0.0786272247439695 0.477112887558009 no 1594 0.468664566178264 2200 2697450 SGTC_1809 st050081 57.6 µM 0.0780938289668107 0.47729442725674 no 1595 0.468876707987769 2232 5036894 SGTC_1457 k015-0032 57.3 µM 0.0779051258828055 0.477358652931914 no 1596 0.468951760970591 2287 4302660 SGTC_2248 tofa 1.1 µM 0.0733667843207049 0.478903464739038 no 1597 0.470757124305829 2158 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_747 3448-8087 38.7 µM 0.0729058912278039 0.479060366838782 no 1598 0.470940502950092 2215 5168703 SGTC_2563 tomatine 8.54 µM 0.0728041635503252 0.479094998488331 no 1599 0.470980978858911 2323 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1664 st014217 9.02 µM 0.0721245776307475 0.479326357274681 no 1600 0.47125138351845 2280 3982782 SGTC_1051 3253-3903 78 µM 0.0716431970065041 0.479490243107271 no 1601 0.471442931069534 2280 5509239 SGTC_2622 2-methoxyxanthone 59.94 µM 0.0710066830064462 0.479706949351874 no 1602 0.471696218324456 2246 71034 A hepatoprotective. SGTC_1146 3579-1023 7 µM 0.0709570578140519 0.479723844895482 no 1603 0.471715966100303 2281 X1146 SGTC_3246 9135460 32.98 µM 0.0709548493871835 0.479724596784043 no 1604 0.47171684492005 2260 41446951 SGTC_954 1189-0853 2.85 µM 0.0704196195055084 0.47990682510037 no 1605 0.471929837952217 2297 2828194 SGTC_927 2425-1185 123 µM 0.0701371718457022 0.48000299101077 no 1606 0.472042240341639 2287 730375 SGTC_42 0133-0086 60.653 µM 0.0694003390303049 0.480253868437102 no 1607 0.472335479532294 2283 162923 Model of phenazepam hydroxylation. SGTC_1331 1472-0049 76.2 µM 0.0691001106078076 0.480356092698979 no 1608 0.472454966494136 2278 24051409 SGTC_114 0364-0001 490.298 µM 0.0653750739665836 0.481624529380448 no 1609 0.473937684854005 2155 4003655 SGTC_2671 danthron 100 µM 0.0651288799059222 0.481708369231566 no 1610 0.474035693200509 2224 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1150 3909-7983 10.9 µM 0.0615177764196405 0.482938199009561 no 1611 0.475473428841178 2209 23965914 SGTC_2866 9034245 58.44 µM 0.0594515984101337 0.483641948892794 no 1612 0.476296208057905 2312 6462273 SGTC_561 1550-0330 72.9 µM 0.0578542015302837 0.484186064778308 no 1613 0.476932381931872 2259 6812934 SGTC_1231 0242-0792 125 µM 0.0576382563304228 0.484259623741967 no 1614 0.477018388083352 2273 3707635 SGTC_1378 2093-0007 380 nM 0.0574891834685429 0.484310403813773 no 1615 0.477077761100552 2244 3618014 SGTC_1155 4088-0394 48.2 µM 0.057161022993455 0.484422189056041 no 1616 0.477208463257122 2276 2326248 SGTC_473 2-arachidonoylglycerol 10 µM 0.0567899443205222 0.484548595513818 no 1617 0.477356262140681 2226 5282280 An endocannabinoid. SGTC_816 0325-0417 81.3 µM 0.0566973812150124 0.484580127005979 no 1618 0.477393130074772 2226 68101 SGTC_2678 equilin 100 µM 0.0563925443467819 0.484683969938504 no 1619 0.477514548127464 2320 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_257 daunorubicin 18.5 µM 0.055492875612118 0.484990448870758 no 1620 0.477872902821991 2298 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3153 9100258 49.47 µM 0.0550572883776549 0.485138838140695 no 1621 0.478046411718808 2264 25236848 SGTC_1940 st075990 51.1 µM 0.0541513184305759 0.485447476845609 no 1622 0.478407302999776 2239 1084979 SGTC_3105 9121040 49.47 µM 0.0541501096400136 0.485447888652721 no 1623 0.478407784530925 2320 41448907 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.0534696613409976 0.485679704170704 no 1624 0.478678851400023 2260 279621 SGTC_3353 9151644 39.2805 µM 0.0530334832735738 0.485828304115949 no 1625 0.478852614723851 2265 4909158 SGTC_705 1124-0212 310 µM 0.0525992517137832 0.485976242867283 no 1626 0.479025606596475 2317 9554485 SGTC_1460 k062-0059 9.15 µM 0.0525550161023416 0.485991313647284 no 1627 0.47904322967711 2282 1373085 SGTC_1747 st037496 66.6 µM 0.052036976196446 0.48616780789752 no 1628 0.479249615284129 2294 723305 SGTC_3156 9099931 49.47 µM 0.0517691778303913 0.486259046859554 no 1629 0.479356307567083 2269 18111053 SGTC_396 dithiazanine 1.25 µM 0.0509582101225291 0.486535348102978 no 1630 0.479679410374106 2248 10578 An antihelmenthic. SGTC_1995 st072814 61.1 µM 0.0497984057057293 0.486930511167493 no 1631 0.480141518585575 2190 5769371 SGTC_2831 7999036 19.48 µM 0.0489545460006758 0.487218035134366 no 1632 0.480477759756652 2303 2988270 SGTC_2656 pseudo-anisatin 100 µM 0.0484500948372921 0.487389917361196 no 1633 0.480678768123098 2306 6708809 A neurotoxin. SGTC_3018 9082602 49.47 µM 0.0481430611800571 0.487494534442163 no 1634 0.480801114057173 2261 17332089 SGTC_3033 9090887 49.47 µM 0.0474307904926219 0.48773723322164 no 1635 0.481084944681976 2297 19325384 SGTC_707 0865-0008 204 µM 0.0468868574226611 0.487922575783407 no 1636 0.481301701415987 2287 723043 SGTC_2016 5121758 140 µM 0.0446564855852611 0.488682591039351 no 1637 0.482190559272047 2340 2795203 SGTC_3087 9117406 49.47 µM 0.0429070453889602 0.489278754277092 no 1638 0.482887816258129 2233 42546093 SGTC_2378 9074213 121.43 µM 0.0410837614239604 0.489900107002636 no 1639 0.48361456008997 2321 657714 SGTC_520 3584-0023 682 µM 0.0400441970852015 0.490254388798045 no 1640 0.484028945176819 2170 1340790 SGTC_2465 5809242 33.21 µM 0.038740634555547 0.49069865156969 no 1641 0.484548588010719 2341 2731748 SGTC_2485 5633444 17.78 µM 0.038375004523476 0.49082326280997 no 1642 0.484694344899624 2291 5724239 SGTC_27 0485-0001 32.618 µM 0.0382975662991894 0.490849654830593 no 1643 0.484725215588192 2339 2054479 SGTC_489 paxilline 115 µM 0.0379676561088459 0.490962093245596 no 1644 0.484856735055522 2242 105008 A toxic potassium channel blocker. SGTC_624 k048-0052 28 µM 0.0378014543070344 0.491018737622292 no 1645 0.484922992416611 2275 6835531 SGTC_2811 7967822 32.47 µM 0.0364276818207555 0.491486949281391 no 1646 0.485470670960895 2326 2232244 SGTC_1388 3346-4487 254 µM 0.0354337237275736 0.491825719252918 no 1647 0.485866946971116 2305 3345614 SGTC_2459 5811157 9.22 µM 0.0337231341786171 0.492408751839426 no 1648 0.486548965527805 2342 2870684 YBR192W RIM2 SGTC_986 1493-0483 84 µM 0.0336939699957812 0.492418692222575 no 1649 0.486560593745158 2345 40079 SGTC_1874 staurosporine 7.6 µM 0.0331640169104938 0.492599323392158 no 1650 0.486771896336976 2334 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_295 k015-0027 31 µM 0.032206073391612 0.492925836229496 no 1651 0.487153856413497 2302 3887424 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.0321022891377568 0.492961211141346 no 1652 0.487195238942331 2339 364106 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0320739173381898 0.492970881692249 no 1653 0.487206551827114 2339 390807 SGTC_2645 abamectin 100 µM 0.0309633636837635 0.493349417995364 no 1654 0.487649378599611 2339 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_960 1222-0186 7.7 µM 0.0307458485411553 0.493423559544859 no 1655 0.487736113290622 2322 3126296 SGTC_425 3825-7017 13.1 µM 0.0303251412257408 0.493566961202333 no 1656 0.48790387299599 2296 3397440 SGTC_1211 1056-0033 32.3 µM 0.0296464367697543 0.493798305118272 no 1657 0.488174515193199 2361 6741922 SGTC_3314 9135860 59.4275 µM 0.0293300703146549 0.49390614283895 no 1658 0.48830067228539 2336 25252478 SGTC_523 1934-0222 13.7 µM 0.0288769418823874 0.494060598475143 no 1659 0.488481367831887 2345 1361595 SGTC_871 0574-0004 149 µM 0.0287981027593606 0.494087472066688 no 1660 0.488512807016231 2260 9551173 SGTC_258 haloperidol 50.781 µM 0.0276849190007789 0.494466921581332 no 1661 0.488956725994069 2338 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1357 1503-1303 39.5 µM 0.0274828263319321 0.494535809196159 no 1662 0.489037318637997 2345 292895 SGTC_966 1300-0360 30.2 µM 0.026213027155078 0.494968651089231 no 1663 0.489543712643134 2347 70588 SGTC_1632 st005650 90 µM 0.026136205090145 0.494994837951227 no 1664 0.489574349716208 2336 2759605 SGTC_126 0417-1624 672.48 µM 0.0242372438710252 0.495642156404892 no 1665 0.490331685267612 2360 41912 YDL195W SEC31 SGTC_1128 3448-9350 235 µM 0.0211690408217736 0.496688069862232 no 1666 0.491555405295657 2301 619386 SGTC_2556 citropten 84.59 µM 0.0206452772048754 0.496866617042962 no 1667 0.491764311082666 2366 2775 A potential DNA crosslinker. SGTC_3006 9075424 71.4286 µM 0.0205446791218007 0.496900910265614 no 1668 0.491804435400985 2340 7465181 SGTC_1102 cgs 12066b 26.1 µM 0.0194086087554967 0.4972881906856 no 1669 0.492257571454565 2317 6438352 A 5-HT1B full agonist. SGTC_52 0329-0193 875 nM 0.0193324343590636 0.497314158232678 no 1670 0.492287954941242 2354 3739292 SGTC_2629 bisabolol 100 µM 0.0191082356252609 0.497390586749952 no 1671 0.492377380775753 2343 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2136 5328288 199.296 µM 0.017742511254116 0.497856159091319 no 1672 0.492922133450362 2350 262395 SGTC_1953 st076800 12.1 µM 0.0175656802259861 0.497916440614802 no 1673 0.492992667831398 2333 297591 SGTC_3176 9106582 49.47 µM 0.017030591021848 0.498098852282074 no 1674 0.493206105600769 2363 17018027 SGTC_496 calpeptin 138 µM 0.0144456466424516 0.498980063562086 no 1675 0.494237221213567 2306 73364 A calpain inhibitor. SGTC_3089 9117425 49.47 µM 0.0132103833108783 0.499401168641043 no 1676 0.49472997283988 2341 9401657 SGTC_1788 fluconazole 20 µM 0.0119668929738694 0.499825079004369 no 1677 0.495226014372274 2322 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_140 0062-0056 502.533 µM 0.0114586313492845 0.499998347318571 no 1678 0.495428767513437 2386 3758964 SGTC_1014 4130-3005 69.3 µM 0.0114489354677855 0.499998347318571 no 1679 0.495432635356795 2382 743608 SGTC_2954 9074818 52.69 µM 0.0111123248779078 0.499883595490621 no 1680 0.495566915008504 2372 16648742 SGTC_465 cgp-37157 41 µM 0.010323307187282 0.499614616418989 no 1681 0.495881669438427 2385 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1183 1254-0324 198 µM 0.00945263557786236 0.499317801430311 no 1682 0.496229000164778 2383 5799357 SGTC_3124 9127567 49.47 µM 0.00890027793212082 0.49912950096757 no 1683 0.496449349703044 2392 17592030 SGTC_2958 9077254 16.72 µM 0.00875519971689028 0.499080043377087 no 1684 0.496507225281878 2369 16457351 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.00821728920203262 0.498896668229087 no 1685 0.496721812799697 2389 2724278 An inhibitor of dopamine biosynthesis. SGTC_2776 terbinafine 19.92 µM 0.00775762284818603 0.498739966910228 no 1686 0.49690518729182 2387 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1667 st014849 34.6 µM 0.0067932685657694 0.498411216974485 no 1687 0.497289898791525 2392 5348460 SGTC_1205 4161-2785 76 µM 0.00567502133577398 0.498030006049587 no 1688 0.4977360061993 2386 3498106 SGTC_330 1488-0319 80.1 µM 0.00424423587824415 0.497542253389223 no 1689 0.498306799943594 2392 6846614 SGTC_1677 st019204 53.9 µM 0.00397472599523717 0.497450378255184 no 1690 0.498414317922709 2370 3945625 SGTC_145 3737-0113 38.366 µM 0.00387106653573833 0.497415041083141 no 1691 0.498455671745648 2396 6849351 SGTC_1519 esterone 74 µM 0.00351031462149481 0.49729206209073 no 1692 0.498599589956022 2396 698 A steroid. SGTC_1567 st069303 68.4 µM 0.00340396421469709 0.497255807679247 no 1693 0.498642017376269 2394 5581319 SGTC_1722 st034304 3.6505 µM 0.00245878147785343 0.496933599844596 no 1694 0.499019089098583 2399 4036148 YLR033W RSC58 SGTC_1067 clotrimazole 1.36 µM 0.00238893504706537 0.496909789639692 no 1695 0.4990469537111 2393 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.00231518298090633 0.496884648040431 no 1696 0.499076376447166 2400 165521 SGTC_1753 st043925 64 µM 0.00192094803970225 0.496750256127564 no 1697 0.499233653079817 2400 670181 SGTC_1978 st071761 42 µM 0.00174531719234326 0.496690384927395 no 1698 0.499303719532756 2398 5147680 SGTC_1849 st056239 19.2 µM 0.000529926618872309 0.496276069778257 no 1699 0.499788589876116 2398 5393181 SGTC_1030 k029-0042 36.7 µM -0.000352973214193347 0.49597510007039 no 1700 0.499859184063933 2407 6080581 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.00151428193408148 0.4955792277087 no 1701 0.499395889142923 2406 6857784 SGTC_1588 farnesol 29.9 µM -0.00180705451267104 0.495479426691083 no 1702 0.499279089944254 2407 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1212 0520-0165 585 µM -0.00255665207965213 0.495223903381936 no 1703 0.498980044500302 2411 5403258 SGTC_1604 st002052 72.4 µM -0.00306642745929455 0.495050131929992 no 1704 0.498776674353854 2437 6254834 YHR062C RPP1 SGTC_1777 st045864 34.765 µM -0.0050439310421357 0.494376052720257 no 1705 0.497987771180133 2416 4691462 SGTC_799 1310-0557 151 µM -0.00630588304758591 0.493945894585639 no 1706 0.497484333309292 2440 5354492 SGTC_2333 9017922 200 µM -0.00677449165099675 0.493786163016111 no 1707 0.497297389524356 2420 3163164 SGTC_1123 mangostin 811.285 nM -0.00698825141193711 0.493713300444803 no 1708 0.497212113737098 2434 5281650 An antioxidant. SGTC_45 0kpi-0036 14.9 µM -0.00793053038848009 0.493392115917983 no 1709 0.496836209285608 2401 2795021 SGTC_435 c-PAF 6.7 µM -0.00971194977422957 0.492784914474991 no 1710 0.49612555351759 2424 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_646 4092-0839 27.3 µM -0.010817450364151 0.492408110032908 no 1711 0.495684545847511 2438 877796 SGTC_1878 temozolomide 1 mM -0.0116449251748453 0.492126073725565 no 1712 0.495354451988581 2421 5394 DNA alkylating agent. SGTC_782 0083-0095 30.5 µM -0.0126557037539042 0.491781565562663 no 1713 0.494951239458694 2423 3591729 An indicator and reagent. SGTC_836 0330-0104 1.35 µM -0.0129414723376277 0.491684166884534 no 1714 0.494837243625485 2430 46494820 SGTC_868 0527-0199 213 µM -0.0132040921451198 0.491594658454773 no 1715 0.494732482433009 2448 2849450 SGTC_2022 5136654 200 µM -0.0140343057108781 0.491311700453085 no 1716 0.494401305864542 2451 1713771 SGTC_2297 7971671 152.32 µM -0.0144284591219381 0.491177364418738 no 1717 0.494244077327653 2448 909016 SGTC_2110 5483698 200 µM -0.0145479103308529 0.491136653051923 no 1718 0.494196428191219 2447 2848765 YHR062C RPP1 SGTC_2787 5284540 71.43 µM -0.0147142515481253 0.49107996078409 no 1719 0.494130074749224 2440 736958 SGTC_1521 st012942 49.4 µM -0.0157717283456002 0.490719556730928 no 1720 0.493708251571709 2457 24207259 SGTC_1076 itraconazole 331 nM -0.0160860434468258 0.490612434847851 no 1721 0.493582873895988 2433 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2985 9022375 71.43 µM -0.0171156912773733 0.490261524851158 no 1722 0.493172160458509 2546 4939335 SGTC_2364 9055074 200 µM -0.0178425302203695 0.490013818414958 no 1723 0.492882237971329 2451 6470630 SGTC_2859 9028643 45.46 µM -0.0179205971802318 0.489987213451998 no 1724 0.492851098739133 2466 17151580 SGTC_1935 st074532 41.6 µM -0.0182139909106718 0.489887226233683 no 1725 0.492734070677801 2535 2829742 SGTC_200 k038-0079 37.545 µM -0.0200564026223383 0.489259355672606 no 1726 0.491999189404851 2468 3436683 SGTC_908 3448-7491 47.7 µM -0.0213681372067222 0.488812349280431 no 1727 0.49147599529266 2446 1203031 SGTC_1180 1193-0155 285 µM -0.0221933736614157 0.488531136468758 no 1728 0.491146851671234 2477 2921347 SGTC_2991 9074669 71.4286 µM -0.0225069251994372 0.488424290143874 no 1729 0.491021793945037 2456 17333109 SGTC_717 1532-0246 73.2 µM -0.0230942478235446 0.488224155386226 no 1730 0.490787547017919 2457 9561992 SGTC_2348 9022543 33.42 µM -0.0231418625176125 0.488207930437713 no 1731 0.490768556578634 2462 3162678 YDL140C RPO21 SGTC_3010 9080089 71.4286 µM -0.0242182363764532 0.487841155844517 no 1732 0.490339265935651 2444 17027233 SGTC_1527 coumarin 137 µM -0.0245280014123594 0.487735605242615 no 1733 0.49021572426668 2541 323 A hepatotoxic, DNA x-linker. SGTC_2552 juarezic acid 87.02 µM -0.0248378762072417 0.487630018100497 no 1734 0.490092139762373 2442 1549512 SGTC_3346 9158254 43.5805 µM -0.0258202707899587 0.487295281455023 no 1735 0.489700346742949 2469 17639500 SGTC_3175 9106517 49.47 µM -0.0275791948540105 0.486695976212318 no 1736 0.488998887727295 2475 41468073 SGTC_1888 azatryptophan 97.5 µM -0.0275804168656617 0.486695559855574 no 1737 0.488998400400557 2526 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_466 geldanamycin 89.2 µM -0.0277081189696229 0.486652050013217 no 1738 0.488947474094826 2461 5288382 HSP90 inhibitor. SGTC_2442 5158906 48.48 µM -0.0277306076685598 0.486644387824296 no 1739 0.488938505848086 2487 1893835 SGTC_721 1187-1332 279 µM -0.0283234728463487 0.486442392821149 no 1740 0.488702079741912 2446 25730 SGTC_1294 1000-1494 117 µM -0.0290181357532207 0.486205718758699 no 1741 0.488425063222573 2462 712797 YDL207W GLE1 SGTC_1037 k284-1091 78.7 µM -0.0293325677643355 0.486098592273962 no 1742 0.488299676375615 2440 3334711 SGTC_3262 9137218 49.47 µM -0.0300180740029829 0.485865044879831 no 1743 0.488026319347864 2448 17650664 SGTC_3330 9141424 71.43 µM -0.0308989152066043 0.485564955297 no 1744 0.487675077525576 2471 27261020 SGTC_1381 2324-0066 62.1 µM -0.0313608924019935 0.485407569749895 no 1745 0.487490864570727 2506 10885928 SGTC_3049 9092223 49.47 µM -0.0342821715859082 0.484412407332353 no 1746 0.486326070763143 2520 8623917 SGTC_738 1315-0003 72.4 µM -0.0346884054280562 0.484274027336286 no 1747 0.486164103246262 2492 6251474 SGTC_223 busulfan 5 mM -0.0349679341814286 0.484178809416664 no 1748 0.486052655022245 2527 2478 A DNA alkylator. SGTC_2187 6125751 200 µM -0.035035723913552 0.484155717841118 no 1749 0.486025627393154 2492 874498 SGTC_788 1182-0090 188 µM -0.0351047441776823 0.484132207157532 no 1750 0.485998109219392 2611 5715185 SGTC_866 0495-0101 262 µM -0.0356207303546243 0.483956446214386 no 1751 0.485792389188644 2489 635694 SGTC_2006 4011487 200 µM -0.0357052443943255 0.48392765839961 no 1752 0.485758694399081 2488 45595294 SGTC_1171 0368-0077 21.4 µM -0.0364315353250193 0.483680267130047 no 1753 0.485469134654883 2466 3239779 SGTC_2261 9010538 184.68 µM -0.0365029948252287 0.483655926731049 no 1754 0.485440645388606 2544 6457250 SGTC_2711 st079103 59.1 µM -0.036862691412027 0.483533408490799 no 1755 0.485297243728112 2510 54693780 SGTC_3126 9127922 49.47 µM -0.03729760513176 0.483385272205197 no 1756 0.485123857496938 2580 45595682 SGTC_150 3970-0969 77.2 µM -0.0390373964172344 0.482792703743406 no 1757 0.484430286648006 2594 6615640 SGTC_1312 1218-2183 165 µM -0.0395625111101736 0.482613858429614 no 1758 0.484220957912458 2460 6744073 SGTC_198 3454-2873 16.191 µM -0.0431422402412062 0.481394757413226 no 1759 0.482794073891995 2501 710957 SGTC_1474 0330-0125 5.35 µM -0.0434033933320915 0.481305826629185 no 1760 0.482689986382155 2502 X1474 SGTC_2833 9001315 45.46 µM -0.0441468296659386 0.481052668446364 no 1761 0.482393682236611 2531 2989378 SGTC_2175 5807670 165.306 µM -0.0446642228557703 0.480876487964038 no 1762 0.48218747562448 2479 241186 SGTC_1711 st032263 62.8 µM -0.0454324386748915 0.480614905349712 no 1763 0.481881312675154 2522 3958979 SGTC_2491 paeonol 100 µM -0.0460604257205532 0.480401077764375 no 1764 0.481631044105289 2479 11092 Increases levels of cortical cytochrome oxidase. SGTC_651 3253-0966 34.4 µM -0.049857747283366 0.479108224237754 no 1765 0.480117874092214 2503 781462 SGTC_1563 conessine 56.1 µM -0.0509881704921716 0.478723397000554 no 1766 0.479667473433672 2520 441082 An anti-amoebic, histamine inhibitor. SGTC_1049 3226-0134 66 µM -0.0513076053142404 0.478614656155911 no 1767 0.479540203962025 2478 5702385 SGTC_639 0833-0042 114 µM -0.0514959938058663 0.47855052637395 no 1768 0.479465147048834 2522 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2891 9063876 19.48 µM -0.0523915363483021 0.478245680194498 no 1769 0.479108358936256 2492 6472478 SGTC_2983 9022671 12.99 µM -0.0524921147608756 0.478211443701667 no 1770 0.479068289091844 2627 6405161 SGTC_183 3914-0051 30.55 µM -0.0530073126206327 0.478036074919671 no 1771 0.47886304063904 2525 1596232 SGTC_1961 st076550 68.7 µM -0.0531945192597947 0.477972352491718 no 1772 0.478788461215841 2558 1579337 SGTC_171 k064-0041 9.68 µM -0.0542676986350962 0.477607068695895 no 1773 0.478360942185273 2508 53325 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.05459339361791 0.477496213861978 no 1774 0.478231201020167 2634 804 An inhibitor of viral and cellular DNA polymerases. SGTC_490 phenamil 164 µM -0.0547291389912477 0.477450011542844 no 1775 0.478177127293988 2535 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_3247 9135149 49.47 µM -0.0552988756685519 0.477256099180047 no 1776 0.477950178942012 2497 8934436 YOR116C RPO31 SGTC_324 1315-0088 19.6 µM -0.0555541829946912 0.477169205962663 no 1777 0.477848482386432 2490 6787421 SGTC_2329 6138490 200 µM -0.0560817949003283 0.476989637998839 no 1778 0.477638323338003 2709 720019 SGTC_1338 1486-1223 76 µM -0.0562064467170828 0.476947214555765 no 1779 0.477588672773022 2562 3444526 SGTC_2243 6634756 200 µM -0.0572468094798956 0.476593152371222 no 1780 0.477174295349979 2615 885676 SGTC_1217 1183-1422 255 µM -0.0572567071209447 0.476589784037904 no 1781 0.477170353228457 2567 2849664 SGTC_1107 amlodipine 47 µM -0.0588775748757087 0.476038198286945 no 1782 0.476524809857866 2542 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2627 acetyl isogambogic acid 100 µM -0.0604242306875256 0.475511909856947 no 1783 0.475908880307514 2577 6857789 A caspase activator and apoptosis inducer. SGTC_1765 st044815 90.4 µM -0.0605602301439174 0.475465634661139 no 1784 0.475854723553168 2567 645695 SGTC_1029 k015-0030 64.7 µM -0.0609552977725819 0.475331210768687 no 1785 0.475697405012797 2634 2208316 SGTC_944 3370-0224 231 µM -0.0613910311111839 0.475182953405905 no 1786 0.475523897512398 2533 4580514 SGTC_813 k007-0158 173 µM -0.0631009912574663 0.474601176414527 no 1787 0.47484304248235 2567 6523916 SGTC_1349 flufenamic acid 69 µM -0.0632761867836654 0.474541572959925 no 1788 0.474773288974624 2518 3371 A non-steroidal anti-inflammatory. SGTC_10 0279-0212 42.575 µM -0.0635395427845977 0.474451977409782 no 1789 0.474668436126808 2528 39851 YBR002C RER2 SGTC_1969 st069479 40.1 µM -0.0666266934411344 0.473401804756012 no 1790 0.473439447332128 2561 3895485 SGTC_1727 st034309 9.9045 µM -0.0673513695051321 0.473155314315565 no 1791 0.473150991370997 2769 870305 SGTC_2194 5927483 104.545 µM -0.0680294988725531 0.472924665519879 no 1792 0.47288107598426 2508 760979 SGTC_2177 5811945 192 µM -0.0683660997257238 0.47281018249896 no 1793 0.472747103584257 2589 5343475 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.0686876273866843 0.472700828195023 no 1794 0.472619133429065 2570 75037 A free radical scavenger. SGTC_2318 6029776 164 µM -0.0687895973625052 0.472666147764584 no 1795 0.472578549287713 2577 818325 SGTC_1385 3091-4834 14.1 µM -0.0688706398079102 0.472638585025653 no 1796 0.472546294525151 2589 4072814 SGTC_2356 9061756 188.97 µM -0.0697299475472388 0.472346340393842 no 1797 0.472204302546807 2521 20104043 SGTC_2275 7947463 200 µM -0.0708702668355535 0.471958548684969 no 1798 0.471750503741368 2504 1225414 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.0714105218843786 0.471774831831248 no 1799 0.471535517868682 2532 3256 An antibiotic and ribosome inhibitor. SGTC_1214 0358-0031 63.7 µM -0.0715981682799041 0.471711022992479 no 1800 0.471460848918422 2742 4301366 SGTC_2986 9022445 71.43 µM -0.0718518201335313 0.471624770264029 no 1801 0.471359916426301 2522 6459286 SGTC_113 0099-0221 2.5 µM -0.0724357547752617 0.471426212001568 no 1802 0.471127565660516 2529 89219 SGTC_2277 7947813 106.88 µM -0.0735537649786706 0.471046069171317 no 1803 0.470682730815865 2762 1246798 SGTC_2855 9016525 58.44 µM -0.0741785986474636 0.470833626372877 no 1804 0.470434137366508 2526 43811474 SGTC_548 1436-0017 110 µM -0.0742874971271386 0.470796601850529 no 1805 0.470390812694603 2541 9677137 SGTC_2684 capsaicin 100 µM -0.0750896523219599 0.470523883960117 no 1806 0.470071690416129 2613 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_754 3474-0146 171 µM -0.0751612696285095 0.470499536074355 no 1807 0.470043199756379 2530 24762078 SGTC_459 nigericin 15.3 µM -0.0755295330059011 0.4703743385459 no 1808 0.469896700349765 2614 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2582 agaric acid 100 µM -0.0755420867260872 0.470370070742326 no 1809 0.469891706407213 2532 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2836 9010338 19.48 µM -0.0760602457448925 0.470193918690897 no 1810 0.469685583891488 2557 2994051 SGTC_1182 1222-0449 220 µM -0.0767826859962619 0.469948329442342 no 1811 0.469398212322332 2597 658318 SGTC_2751 anetholtrithion 17.25 µM -0.0769604972739332 0.46988788530992 no 1812 0.469327485166775 2615 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1647 st011722 22.4 µM -0.0801384520524471 0.468807708168404 no 1813 0.468063570381083 2612 2854783 SGTC_742 0kpi-0133 140 µM -0.0803367194694778 0.468740325203498 no 1814 0.467984727333201 2632 2728852 SGTC_1277 0873-0036 22 µM -0.0808108300427963 0.468579198095379 no 1815 0.467796197556229 2619 5965735 SGTC_2156 5649887 115 µM -0.0816478792930001 0.468294738376462 no 1816 0.467463363098024 2655 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1707 st032323 6.317 µM -0.0824970079378117 0.468006190180351 no 1817 0.467125748772958 2559 3132057 YMR211W DML1 SGTC_760 0568-0725 82.9 µM -0.0839677664671323 0.467506441550516 no 1818 0.466541029933623 2594 3916171 SGTC_1111 tnp00062 510.699 nM -0.0841813997808153 0.46743385538747 no 1819 0.466456103257106 2667 676306 SGTC_1613 st002381 52.1 µM -0.0855567850092508 0.466966566960416 no 1820 0.465909376501928 2573 551167 SGTC_873 0591-4978 488 µM -0.0866288502800275 0.466602363314417 no 1821 0.46548326644635 2677 3305145 SGTC_3237 9133362 49.47 µM -0.0867446232466942 0.466563034413444 no 1822 0.465437252926619 2556 43845137 SGTC_1398 3558-0053 112 µM -0.0886974134402636 0.465899707184969 no 1823 0.464661194105334 2565 4532369 SGTC_1875 nocodazole 6 µM -0.0892397805771881 0.465715491685306 no 1824 0.464445675574557 2543 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2385 9074692 200 µM -0.0910896638898036 0.465087232602087 no 1825 0.463710672759936 2589 17046906 SGTC_505 gw-5074 63.9 µM -0.0913700368783867 0.464992019623402 no 1826 0.463599284622063 2680 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2095 5432005 200 µM -0.0964884856015023 0.463254183028094 no 1827 0.461566309208014 2608 783734 SGTC_282 k297-0036 65.7 µM -0.0966063313345452 0.463214179692728 no 1828 0.461519514169285 2693 5061378 SGTC_1137 ixabepilone 100 µM -0.0983159459931437 0.46263388431891 no 1829 0.460840708226848 2576 154225 A novel microtubule stabilizer. SGTC_2806 7952793 58.44 µM -0.0992573944770871 0.462314361851821 no 1830 0.460466952795469 2691 2972490 SGTC_1325 1431-0015 227 µM -0.0997048780972746 0.462162496871771 no 1831 0.460289313841058 2582 1103340 SGTC_1135 dihydrocapsaicin 536.708 nM -0.100801392727571 0.461790390027163 no 1832 0.459854060618688 2569 107982 A Capsaicinoid. SGTC_1607 st000305 50.6 µM -0.101248686860983 0.461638608469971 no 1833 0.459676524366807 2704 5457690 SGTC_1348 1493-0373 93.8 µM -0.101834152664757 0.461439949182986 no 1834 0.459444158324036 2651 3010129 SGTC_2861 9024595 19.48 µM -0.10285515717756 0.461093526671163 no 1835 0.459038964128329 2551 16482810 SGTC_1732 st034308 51.822 µM -0.103057827421334 0.461024765018187 no 1836 0.458958537792003 2556 830119 SGTC_2324 6149169 200 µM -0.103508856600724 0.460871744707282 no 1837 0.45877956035086 2649 2888231 SGTC_911 3456-4043 236 µM -0.103877093572295 0.46074681753779 no 1838 0.458633442715333 2671 914281 SGTC_1884 5633444 25 µM -0.104153549591321 0.460653030293918 no 1839 0.458523747734222 2704 5724239 SGTC_2898 9056270 58.44 µM -0.105317761782463 0.460258097324938 no 1840 0.458061834744861 2576 19154699 SGTC_1256 0570-0116 285 µM -0.106581479411975 0.459829453743871 no 1841 0.457560506084191 2623 410638 SGTC_1555 citronellol 128 µM -0.1075340943669 0.459506364699831 no 1842 0.457182639367591 2590 8842 A terpine precursor. SGTC_1077 5-fluorocytosine 377 nM -0.108777468644039 0.459084701937528 no 1843 0.456689497586706 2676 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3232 9132874 49.47 µM -0.109030611698941 0.458998859718378 no 1844 0.456589105219302 2611 3784940 SGTC_3141 9094609 49.47 µM -0.109278913520157 0.458914661045777 no 1845 0.45649063549727 2591 25236309 YDL196W YDL196W SGTC_2502 avocadyne acetate 18.59 µM -0.110500551450965 0.458500432872804 no 1846 0.45600620627711 2564 3952079 SGTC_1074 carmofur 3.8 µM -0.112666368660254 0.45776616715458 no 1847 0.455147532677511 2591 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2792 7535235 81.82 µM -0.113611287198538 0.457445861356562 no 1848 0.454772969699733 2683 1281891 SGTC_1441 4106-0040 13 µM -0.114135172487355 0.457268288108199 no 1849 0.454565320390152 2601 2904180 SGTC_2997 9067075 71.4286 µM -0.116341328935051 0.456520595588078 no 1850 0.453691016115021 2691 27209819 SGTC_3342 9147791 14.508 µM -0.11762829397185 0.456084498823703 no 1851 0.453181092614003 2612 1838168 SGTC_2869 9037858 32.47 µM -0.119612849185899 0.455412122794152 no 1852 0.452394920314093 2592 27187042 SGTC_1066 ketoconazole 628 nM -0.121441198743122 0.454792782896448 no 1853 0.451670793231535 2747 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_313 3474-0040 5.03 µM -0.12328310627192 0.454168961440742 no 1854 0.450941459009487 2609 1043375 YIL048W NEO1 SGTC_2752 diclazuril 33.15 µM -0.124226418058194 0.453849522120002 no 1855 0.450568002831375 2721 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2505 galangin 7.89 µM -0.125491183080013 0.453421274046448 no 1856 0.450067352372082 2606 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2331 7980721 200 µM -0.125659982597055 0.453364122797524 no 1857 0.450000539980026 2733 2981221 SGTC_2430 5571206 200 µM -0.126223680156144 0.453173276060278 no 1858 0.44977743361159 2691 1731771 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.126654160060085 0.453027539078448 no 1859 0.449607064266079 2674 279621 SGTC_298 1391-0729 10 µM -0.127741931079071 0.452659307463337 no 1860 0.449176602851012 2633 3237558 SGTC_939 1165-0479 45.3 µM -0.128091715426559 0.45254090730377 no 1861 0.449038196086365 2646 1377347 SGTC_716 1683-5115 658 µM -0.128321133926668 0.45246325264058 no 1862 0.448947420455408 2622 723597 SGTC_1936 st074407 74.3 µM -0.128469099808177 0.452413169410829 no 1863 0.448888875172025 2624 809813 SGTC_2607 solasodine 47.35 µM -0.128911272651807 0.452263508044319 no 1864 0.448713928406378 2667 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1958 st076513 41.9 µM -0.12892665855911 0.452258300528739 no 1865 0.448707841113904 2632 732122 YGL099W LSG1 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.130242850516292 0.451812852574948 no 1866 0.448187146739142 2834 165506 SGTC_3325 9138760 55.175 µM -0.130368148909059 0.451770450126051 no 1867 0.448137582492535 2665 43844959 SGTC_1023 4482-3888 16 µM -0.132747560981643 0.450965334087975 no 1868 0.447196513732455 2813 3303168 SGTC_2572 astragaloside iv 100 µM -0.132982290187056 0.450885920198104 no 1869 0.44710369323876 2830 45006101 An anti-inflammatory agent. SGTC_158 k038-0087 26.446 µM -0.134296137786637 0.450441453958208 no 1870 0.446584203589111 2636 X158 SGTC_2926 9010726 65.15 µM -0.134606220653035 0.450336563951453 no 1871 0.446461611502406 2739 2994293 SGTC_2766 oltipraz 83.91 µM -0.135106474500251 0.450167353179972 no 1872 0.446263845603321 2735 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_344 k064-0035 6.43 µM -0.135268990718903 0.450112384047001 no 1873 0.446199600763398 2664 5088750 SGTC_1215 3852-0577 11.2 µM -0.135632871710021 0.449989309202704 no 1874 0.446055758853194 2797 2884876 SGTC_655 k060-0012 42 µM -0.136058836849482 0.449845241855005 no 1875 0.445887384141578 2661 5994525 SGTC_2294 7971431 200 µM -0.136623542365451 0.449654260771243 no 1876 0.445664183438977 2760 5741572 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.136892417028415 0.449563332560834 no 1877 0.445557916371985 2661 688662 SGTC_977 1348-1378 135 µM -0.136936528061246 0.44954841531548 no 1878 0.445540482785402 2637 X977 SGTC_1749 st037932 54.2 µM -0.13730197340737 0.449424833605969 no 1879 0.445396055328508 2767 594497 SGTC_906 1165-0455 526 µM -0.138788275043855 0.448922265489916 no 1880 0.444808729735757 2637 3252859 SGTC_3271 9137798 49.47 µM -0.140049697266549 0.448495800848761 no 1881 0.444310362270736 2679 6498326 SGTC_535 2293-4129 48.2 µM -0.141666398110771 0.447949309838265 no 1882 0.443671758809025 2765 396118 YIL048W NEO1 SGTC_593 1203-0218 61.7 µM -0.144029260352688 0.447150772948737 no 1883 0.442738682053152 2774 3666956 SGTC_2484 5809818 12.04 µM -0.14472755706344 0.446914822190566 no 1884 0.442462990416137 2721 2870548 SGTC_3025 9087895 49.47 µM -0.144846895799664 0.446874500141668 no 1885 0.442415877567057 2728 17173641 SGTC_1239 0337-0584 35.4 µM -0.146098988958409 0.446451477386166 no 1886 0.441921622274027 2807 914301 YML130C ERO1 SGTC_2397 5161689 200 µM -0.14617460875953 0.446425930996544 no 1887 0.44189177475705 2821 2259942 SGTC_1467 k284-1082 293 µM -0.147399608126594 0.446012124524407 no 1888 0.441408307406984 2753 3334705 SGTC_221 trifluoperazine 10.304 µM -0.148539846301201 0.4456270033242 no 1889 0.440958370962467 2677 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2428 5615643 7.78 µM -0.148865487116593 0.445517025896345 no 1890 0.440829887499704 2760 2253075 SGTC_2247 cerulenin 830 nM -0.150049878715257 0.445117061264771 no 1891 0.440362631581151 2899 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2786 7743617 45.45 µM -0.151501311763773 0.444626993945117 no 1892 0.439790138072002 2725 583674 SGTC_3259 9138485 49.47 µM -0.151502184382334 0.444626699336282 no 1893 0.439789793919937 2884 17646153 SGTC_1531 st059297 52.4 µM -0.152458490970412 0.444303854616491 no 1894 0.439412663534163 2793 7566702 SGTC_2054 5233173 129 µM -0.153211971745229 0.444049508977058 no 1895 0.439115558524871 2799 6889 SGTC_1573 oleylamine 1.06 µM -0.153865391746852 0.4438289585928 no 1896 0.438857936240966 2654 5356789 An amine of the fatty acid oleic acid. SGTC_3142 9086498 49.47 µM -0.15388792659191 0.443821352663675 no 1897 0.438849051944874 2788 25236367 SGTC_925 2064-1272 59.6 µM -0.154175035793053 0.443724449783287 no 1898 0.438735862688826 2712 6815817 SGTC_1422 4031-0024 15.5 µM -0.154966181438085 0.443457445842475 no 1899 0.438423989242941 2660 782427 SGTC_1626 st003712 1.76 µM -0.157544984754467 0.442587303691064 no 1900 0.437407678904929 2832 24207035 SGTC_1911 st060208 74.3 µM -0.159127861156535 0.442053344962314 no 1901 0.436784068930393 2796 688783 SGTC_2245 6637752 200 µM -0.160794868090292 0.441491119932829 no 1902 0.436127483656465 2863 681890 SGTC_3273 9137859 49.47 µM -0.162056501315699 0.441065692037964 no 1903 0.435630680120741 2690 2377234 SGTC_2598 perillyl alcohol 100 µM -0.162567756720141 0.440893313953213 no 1904 0.435429387812615 2837 10819 An apoptosis inducer. SGTC_1649 st011737 51.3 µM -0.163089474267022 0.440717419931392 no 1905 0.4352239935796 2740 1761035 SGTC_2514 salinomycin 42.74 µM -0.163925884899753 0.440435453394161 no 1906 0.434894744765843 2841 23682228 A polyether potassium ionophore. SGTC_2742 clothiapine 36.27 µM -0.164805085421692 0.440139094305465 no 1907 0.434548700595852 2711 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1216 1165-0504 9.65 µM -0.16566725823594 0.439848507445546 no 1908 0.434209407042568 2750 6304004 SGTC_9 0092-0002 10.449 µM -0.165801727764579 0.439803188731528 no 1909 0.434156493192243 2724 759368 SGTC_1488 4013-0813 75.9 µM -0.166537908228319 0.439555096317234 no 1910 0.43386682661595 2706 2910057 SGTC_60 0986-0278 202 µM -0.166783536302458 0.439472325066759 no 1911 0.433770186680688 2699 3110598 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.167091376613384 0.439368593399433 no 1912 0.433649075547125 2786 16725076 SGTC_2283 7944793 200 µM -0.168133899981789 0.439017329606375 no 1913 0.433238970313689 2758 2970533 SGTC_2433 5607874 27.82 µM -0.168284759622603 0.438966503512887 no 1914 0.433179631468719 2707 2252428 SGTC_2047 4141938 200 µM -0.168356260837194 0.438942414403455 no 1915 0.43315150784271 2710 3807862 SGTC_110 0850-0284 111.64 µM -0.168572953875079 0.438869410839142 no 1916 0.433066277876927 2675 3906265 SGTC_1017 4239-0030 168 µM -0.169134574757295 0.438680211278963 no 1917 0.432845394977859 2734 1149593 SGTC_2486 5283202 22.39 µM -0.16952372041088 0.438549123609258 no 1918 0.432692358090696 2773 1377751 SGTC_1499 4480-0877 67.3 µM -0.170010051067594 0.438385307661466 no 1919 0.432501116057443 2712 2861909 SGTC_811 0416-0114 265 µM -0.1728837861332 0.437417533198463 no 1920 0.431371388267201 2796 6612453 SGTC_39 0986-0283 58.349 µM -0.173498548128886 0.437210551049466 no 1921 0.431129784500799 2819 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_6 0844-0013 19.835 µM -0.173991953706088 0.437044440412818 no 1922 0.430935892897215 2755 1584900 SGTC_2682 pyrogallin 40.03 µM -0.174069587588053 0.437018305087353 no 1923 0.430905386937435 2752 822798 An ATP competetive kinase inhibitor. SGTC_838 0109-0203 71.4 µM -0.174173391216312 0.436983360187035 no 1924 0.430864598312405 2717 759422 SGTC_1084 voriconazole 435 nM -0.174655401393948 0.436821100652196 no 1925 0.430675206775537 2735 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_701 4424-0219 185 µM -0.175697287268345 0.436470405991704 no 1926 0.430265883299695 2823 2911779 SGTC_854 0422-0053 192 µM -0.176133771531755 0.436323501941153 no 1927 0.430094424904212 2728 3596728 SGTC_1328 1441-0025 69.2 µM -0.177229132625773 0.435954883655736 no 1928 0.429664206668554 2693 4562601 SGTC_2519 cryptotanshinone 88.04 µM -0.177490715109975 0.435866862374481 no 1929 0.429561478860128 2825 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.178026844223243 0.435686467369974 no 1930 0.429350946919545 2845 6708760 SGTC_1163 k060-0048 49.9 µM -0.178942402996059 0.435378434047577 no 1931 0.428991463659292 2732 6809982 SGTC_703 3875-0075 71.8 µM -0.179274529706783 0.435266702028374 no 1932 0.428861072598374 2744 2850814 SGTC_1088 bifonazole 369 nM -0.179321639744898 0.43525085397828 no 1933 0.428842578093264 2694 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1587 estradiol valerate 56.1 µM -0.180485679669711 0.434859298280535 no 1934 0.428385647878575 2823 13791 A steroid. SGTC_3210 9128157 49.47 µM -0.181098719039837 0.434653111885488 no 1935 0.428145045015986 2875 17590849 SGTC_2878 9043973 25.97 µM -0.181514167081533 0.434513392404136 no 1936 0.427982007064795 2900 6465167 SGTC_379 3970-0972 5.9 µM -0.181783990639696 0.434422652325461 no 1937 0.427876124401915 2787 2898042 YBL034C STU1 SGTC_657 3534-0529 86.7 µM -0.18256554149732 0.434159840872049 no 1938 0.427569461886629 2894 1049549 SGTC_1487 3970-0795 2.82 µM -0.182607856333303 0.434145612526876 no 1939 0.427552859768715 2807 3765103 SGTC_983 1491-0821 12.2 µM -0.183181576520599 0.433952707791343 no 1940 0.427327774790067 2881 46495113 SGTC_2941 9056145 11.23 µM -0.183339519268582 0.433899604690317 no 1941 0.427265813993947 2688 2119517 SGTC_1100 amiodarone 5.07 µM -0.184009827613129 0.433674248643947 no 1942 0.427002872624325 2836 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1259 0671-0132 43 µM -0.185525803742924 0.433164660757861 no 1943 0.426408321551084 2767 X1259 SGTC_542 3381-0244 89.3 µM -0.18576320328409 0.433084870115504 no 1944 0.426315230870968 2913 1112843 SGTC_2346 9031566 143.75 µM -0.185825731368812 0.433063854707017 no 1945 0.426290712627153 2849 4771086 SGTC_2114 5491910 81.25 µM -0.185921553551482 0.433031649669059 no 1946 0.426253139797597 2847 2849228 SGTC_1814 st052110 31.539 µM -0.186118438292244 0.43296547974256 no 1947 0.426175941436226 2837 674163 SGTC_3017 9080681 49.47 µM -0.186175313187007 0.432946365316931 no 1948 0.4261536413585 2814 16451914 SGTC_3051 9093778 49.47 µM -0.186185518556919 0.43294293552878 no 1949 0.426149639959952 2705 17217378 SGTC_1315 1237-0019 3.69 µM -0.189001030484323 0.431996901087297 no 1950 0.425046004568612 2839 825140 SGTC_2154 5570129 200 µM -0.189336954649967 0.431884053814778 no 1951 0.424914366737848 2717 673366 SGTC_2184 6075246 200 µM -0.194202601667312 0.430250160946454 no 1952 0.42300862290875 2810 2267320 SGTC_2222 6885208 172.143 µM -0.195901985336702 0.429679784703455 no 1953 0.422343441652481 2788 609514 SGTC_2057 5236571 38.335 µM -0.197754186245554 0.429058284491688 no 1954 0.421618696142052 2889 54684039 YBR257W POP4 SGTC_2371 9071574 200 µM -0.198046348949012 0.428960266228164 no 1955 0.421504400315602 2792 45596039 SGTC_2253 7938677 135.83 µM -0.199523958024567 0.428464607360616 no 1956 0.420926452152317 2966 2301972 SGTC_1685 st024049 53.0905 µM -0.200785468982544 0.428041527105952 no 1957 0.420433162810075 2848 1941139 SGTC_942 3253-1115 227 µM -0.201131662726497 0.427925436542692 no 1958 0.420297812289611 2927 46497897 SGTC_2212 7123476 200 µM -0.201846888809572 0.427685616625784 no 1959 0.420018211963966 2790 1085715 SGTC_2903 5923464 63.88 µM -0.202118357402046 0.427594598445812 no 1960 0.419912098448151 2855 2876576 SGTC_1428 4049-0204 61.7 µM -0.204441272354146 0.426815927932324 no 1961 0.419004340259976 2868 X1428 SGTC_274 sirtinol 40.1 µM -0.204713682685142 0.426724631159194 no 1962 0.41889791478326 2804 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_470 aa-861 153 µM -0.205522540324542 0.426453570273111 no 1963 0.418581944663515 2787 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3096 9117468 49.47 µM -0.206146911661289 0.426244357389968 no 1964 0.418338077719208 2917 41316311 SGTC_1227 3909-8010 46.6 µM -0.20617322985429 0.426235539207036 no 1965 0.41832779904865 2791 15982272 SGTC_3060 1327-0027 12.5 µM -0.206258246313978 0.426207053814392 no 1966 0.418294595927491 2861 16000455 YPR107C YTH1 SGTC_2772 vinpocetine 57.06 µM -0.208812111452218 0.42535154258073 no 1967 0.417297458090086 2960 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1287 0971-0001 34.6 µM -0.209153369344006 0.425237252199408 no 1968 0.417164256587114 2778 4665869 SGTC_2171 5739187 198.077 µM -0.211362819311688 0.424497439679061 no 1969 0.416302083610548 2735 2262761 SGTC_1879 gemcitabine 100 µM -0.211871128300504 0.424327274961025 no 1970 0.416103787763391 2803 60750 A nucleoside analog which inhibits DNA replication. SGTC_2252 omeprazole 400 µM -0.211979011445951 0.424291161133291 no 1971 0.416061704336465 2841 4594 A proton pump inhibitor. SGTC_2814 7977482 42.97 µM -0.212247432439799 0.424201310101831 no 1972 0.415957001932825 2944 6456762 SGTC_2432 5630864 12.22 µM -0.212267833486078 0.424194481232744 no 1973 0.415949044384101 2933 5714970 SGTC_1882 5615643 20 µM -0.213366952389627 0.423826605409743 no 1974 0.415520377579282 2740 2253075 SGTC_402 epigallocatechin gallate 10 µM -0.213513224250935 0.423777653118529 no 1975 0.415463337732825 2805 65064 An antioxidant. SGTC_2020 4017018 200 µM -0.218873537865586 0.421984553135853 no 1976 0.413374280206128 2894 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2138 5575593 77.673 µM -0.218905893747927 0.421973734509729 no 1977 0.41336167763373 2798 762213 SGTC_1789 tunicamycin 25 nM -0.21935157855146 0.421824719772984 no 1978 0.413188093094061 2907 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1910 st062352 60.4 µM -0.220394899242297 0.421475929251399 no 1979 0.412781808786108 2755 2245730 SGTC_477 mead ethanolamide 10 µM -0.220521739566692 0.421433529702449 no 1980 0.412732421672202 2769 16061185 SGTC_2843 9000894 45.46 µM -0.222896489733062 0.420639878807159 no 1981 0.411808034228208 2755 2242070 SGTC_2623 humulene 100 µM -0.225153054345403 0.419886024725034 no 1982 0.410930104487234 2885 6187145 An anti-inflammatory. SGTC_2268 7933382 153.85 µM -0.225506080266773 0.419768115314176 no 1983 0.410792797906559 2758 935025 YOR257W CDC31 SGTC_581 0958-0271 211 µM -0.225976760925551 0.419610920840879 no 1984 0.410609747470679 2797 4591145 SGTC_570 0987-0065 62.6 µM -0.226359552978941 0.419483088216027 no 1985 0.410460891776146 2751 3104428 SGTC_3162 9099653 49.47 µM -0.226443072739222 0.419455198091335 no 1986 0.410428415302375 2843 25237511 SGTC_2560 caryophyllene 100 µM -0.228076559384296 0.41890980215465 no 1987 0.409793361384887 2789 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2436 5633522 8.09 µM -0.229229323218819 0.418525005843276 no 1988 0.409345341327273 2946 5724242 SGTC_16 erodoxin 22.806 µM -0.22981705765581 0.41832884815986 no 1989 0.409116964683173 2880 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_893 0958-0369 48.9 µM -0.230174120883237 0.418209687423285 no 1990 0.408978235272516 2962 6819948 SGTC_3102 9121669 49.47 µM -0.23023510284015 0.418189337002214 no 1991 0.408954543154561 2838 41905072 SGTC_762 1165-0429 115 µM -0.230521251791314 0.418093848541122 no 1992 0.40884337578553 2961 5967793 SGTC_1892 st058411 7.36 µM -0.23058495356094 0.418072591793611 no 1993 0.408818628979215 2940 3934738 SGTC_2021 4019055 173 µM -0.232263412521672 0.417512590492534 no 1994 0.408166714005113 2920 44827708 YER133W GLC7 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.232813266810514 0.417329173340355 no 1995 0.407953205273585 2880 756377 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.233030558101207 0.417256695549146 no 1996 0.407868838473263 2945 5024745 SGTC_99 0109-0120 622.8 µM -0.234230075165488 0.41685664574319 no 1997 0.407403183873986 2922 759414 SGTC_952 1185-0122 232 µM -0.237536510648287 0.415754366431692 no 1998 0.406120299078674 2773 678600 SGTC_1170 0310-0127 64.8 µM -0.238160596745546 0.415546386474626 no 1999 0.40587826856217 2902 774975 SGTC_2451 5856223 45.7 µM -0.238386907773668 0.415470972982214 no 2000 0.405790510427746 2864 2179896 SGTC_2008 4012253 172 µM -0.239104470570223 0.415231880547923 no 2001 0.405512287647752 2813 603940 SGTC_3099 9120367 49.47 µM -0.239293076722187 0.41516904204954 no 2002 0.40543916673372 2818 24824940 SGTC_1803 st050068 52.4 µM -0.239516921009866 0.415094465967962 no 2003 0.405352388593086 2845 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2763 lisinopril 49.32 µM -0.239696340067695 0.415034692828103 no 2004 0.405282836224634 2838 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2605 digitonin 300 nM -0.240071337155038 0.414909769568277 no 2005 0.405137477072367 2900 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2387 9077560 195.08 µM -0.240928392503243 0.4146242899448 no 2006 0.404805308082297 2829 5303272 SGTC_3074 9116018 49.47 µM -0.242504595033591 0.414099384834995 no 2007 0.404194598391216 2802 17027303 SGTC_697 0508-1955 564 µM -0.243441629034945 0.413787407523593 no 2008 0.403831649134864 2972 6243113 SGTC_2090 5301565 104.445 µM -0.243459423093979 0.413781483672367 no 2009 0.403824757612407 2848 2056344 SGTC_2153 5569715 200 µM -0.243537509927153 0.413755487880543 no 2010 0.403794515446632 2841 2054701 SGTC_573 3702-0553 84.7 µM -0.24399262204004 0.413603984589847 no 2011 0.403618267014574 2845 1222756 SGTC_367 0335-0881 7.1 µM -0.244147807194236 0.413552327595451 no 2012 0.403558173899434 2993 23828853 SGTC_750 4073-0104 132 µM -0.244772254949471 0.413344480742203 no 2013 0.403316388932287 2918 22330957 SGTC_272 doxorubicin 8.13 µM -0.245678627781404 0.413042838605676 no 2014 0.402965508887698 2820 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2107 5363541 170.161 µM -0.245858973496472 0.412982825418572 no 2015 0.402895701771075 2882 244052 SGTC_3195 9113082 49.47 µM -0.247470719656408 0.412446579183295 no 2016 0.402271974608357 2892 17018038 SGTC_493 zm226600 134 µM -0.249179550905344 0.411878210102082 no 2017 0.401610948325131 3031 5240098 A potassium channel opener. YCR052W RSC6 SGTC_862 0452-0056 10.2 µM -0.250458381742609 0.411452982972088 no 2018 0.401116442873243 2883 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_222 nsc-310342 10.666 µM -0.252890060750936 0.410644706768227 no 2019 0.400176585129967 2861 432556 SGTC_2957 9076800 11.52 µM -0.253715686098572 0.410370359709145 no 2020 0.399857607375957 2898 16459615 SGTC_2642 cholecalciferol 100 µM -0.254880132464832 0.409983500382014 no 2021 0.399407840798433 2952 9821465 A vitamin D precursor, similar to steriods. SGTC_987 1497-1013 404 µM -0.255704330401633 0.409709733342621 no 2022 0.399089575567639 2842 1676435 SGTC_1719 st032227 49.2 µM -0.257982490336061 0.408953245083896 no 2023 0.398210210312797 2881 3125804 SGTC_2478 5763493 32.33 µM -0.261373002986138 0.407828016271485 no 2024 0.396902437054311 2858 1365576 YLR208W SEC13 SGTC_123 0083-0120 66.675 µM -0.261511722059757 0.407781994897628 no 2025 0.396848955530414 2872 16001701 SGTC_2691 st077356 60.2 µM -0.262020658763324 0.407613161201677 no 2026 0.396652757532679 3041 2839272 SGTC_3053 9095903 49.47 µM -0.262443991478579 0.407472738680564 no 2027 0.396489580289023 2928 17174018 SGTC_1058 3448-5425 97.3 µM -0.262705232415151 0.407386089104771 no 2028 0.396388891762013 2824 7279705 SGTC_994 3910-0338 138 µM -0.263044372993715 0.407273608183729 no 2029 0.396258189152142 3057 3479481 SGTC_2062 5245942 200 µM -0.265295735831767 0.406527105126193 no 2030 0.395390824586661 2851 1376160 SGTC_2588 indole-3-carbinol 100 µM -0.266021824525227 0.406286422161503 no 2031 0.395111200451403 3016 3712 Induces cell cycle arrest. SGTC_283 0987-0079 11.7 µM -0.267937022898262 0.405651744708466 no 2032 0.394373897547305 2965 411556 SGTC_1822 st052468 42 µM -0.26906737820332 0.405277272589987 no 2033 0.393938916703416 2930 2873678 SGTC_904 1141-0088 396 µM -0.271730712392802 0.404395287731993 no 2034 0.392914542222721 2935 1378119 SGTC_112 phenothiazine 287.218 µM -0.271771344021957 0.404381835986048 no 2035 0.392898920163585 3010 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1132 3456-3614 2.5 µM -0.272611081845131 0.404103852777984 no 2036 0.392576096210018 3151 3125502 SGTC_2944 9067346 25.62 µM -0.273988495499812 0.403647984570726 no 2037 0.39204673137528 3057 6473075 SGTC_1575 cyproterone acetate 48 µM -0.274246472422069 0.403562619175455 no 2038 0.391947608385606 2950 9880 An androgen receptor antagonist and liver toxin. SGTC_2768 sulfasalazine 50.2 µM -0.27490103889496 0.403346041645055 no 2039 0.391696134482369 3007 5384001 An antioxidant and salicylic acid derivative. SGTC_673 1082-0474 110 µM -0.277487070964346 0.402490687268441 no 2040 0.390703066034726 2926 3098046 SGTC_1050 3232-1156 69.3 µM -0.278748474001498 0.402073635426734 no 2041 0.390218929695371 2931 700529 SGTC_1560 lithocholic acid 53.1 µM -0.280158946362016 0.401607429506316 no 2042 0.389677780976653 2934 9903 A bile acid which acts as a detergent. SGTC_1657 st012939 43.4 µM -0.280217224185545 0.401588169841764 no 2043 0.389655426414561 3050 24207257 SGTC_373 0844-0104 25.9 µM -0.280373026326898 0.40153668149881 no 2044 0.389595664674085 3034 5375804 SGTC_2972 9093619 59.92 µM -0.281010727175543 0.401325956650195 no 2045 0.389351086064103 2880 25236256 SGTC_1766 st045414 44.774 µM -0.28127027010183 0.401240200285669 no 2046 0.389251555618595 2895 253960 SGTC_349 k015-0014 24 µM -0.281566651543561 0.40114227781402 no 2047 0.389137907094069 2852 2196908 SGTC_3150 9097574 49.47 µM -0.281858936998636 0.401045714710728 no 2048 0.389025838478255 3059 17217476 SGTC_1994 st072947 40.9 µM -0.285233503142789 0.399931289754458 no 2049 0.387732627097645 3018 5286565 YDL195W SEC31 SGTC_2727 riluzole 51.77 µM -0.285737965924563 0.399764764497852 no 2050 0.387539411921664 2924 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1839 st053978 48 µM -0.285982631138642 0.399684006058668 no 2051 0.387445712294304 2999 3788398 SGTC_2127 5253358 187.912 µM -0.285988780614133 0.399681976311523 no 2052 0.38744335730933 2845 20612 SGTC_304 1310-0298 97 µM -0.286116437164478 0.399639841538672 no 2053 0.387394471269294 2949 1550234 SGTC_1036 k216-0215 33.5 µM -0.286393478377038 0.399548404356493 no 2054 0.387288384558044 2883 622330 SGTC_2689 tacrolimus 100 µM -0.287902415182399 0.399050478080046 no 2055 0.386710719054548 2979 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_953 1188-0045 9.7 µM -0.290137101538415 0.398313367349521 no 2056 0.385855676507728 3027 6144426 SGTC_501 nsc-95397 161 µM -0.290578662277606 0.398167761481666 no 2057 0.385686790632085 3079 262093 SGTC_1022 4477-0945 21.3 µM -0.290862537775574 0.398074160242383 no 2058 0.385578226835767 2917 4648966 SGTC_1671 st016596 74.5 µM -0.291705363404707 0.3977962929807 no 2059 0.385255954045786 2959 2829167 SGTC_3059 1327-0034 3 µM -0.292123114213652 0.397658585865616 no 2060 0.385096247250819 2922 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_606 k015-0008 38.6 µM -0.292396756013278 0.397568389665183 no 2061 0.384991644120307 3060 1970475 SGTC_3256 9138902 49.47 µM -0.292728925574903 0.397458909246604 no 2062 0.384864679239262 2923 17228773 SGTC_2714 st079313 56.9 µM -0.294064857610235 0.397018678432605 no 2063 0.384354171901142 2918 2939799 SGTC_3300 9124615 50.48 µM -0.297109440038724 0.396015885617057 no 2064 0.383191478755701 3107 24824903 SGTC_2343 7990716 14.84 µM -0.297335172552669 0.395941563500325 no 2065 0.383105315687142 2914 6456862 SGTC_2924 9010168 62.78 µM -0.297486891577822 0.395891612347472 no 2066 0.383047407133995 3023 2993929 SGTC_931 2812-0076 566 µM -0.298279615240671 0.395630648108292 no 2067 0.38274488062189 2896 3450959 SGTC_1452 4194-0072 190 µM -0.300051848657021 0.395047399115518 no 2068 0.382068803518811 3090 1343545 SGTC_2025 5147754 141 µM -0.300335319786363 0.394954129425767 no 2069 0.381960697364877 3017 315777 YLR208W SEC13 SGTC_1706 st031321 9.9705 µM -0.302278218133517 0.394315025451052 no 2070 0.381219990783878 3049 6103185 SGTC_2820 7989630 71.43 µM -0.302584006495804 0.394214464187644 no 2071 0.381103452199965 3004 2984098 SGTC_1770 st043884 66.3 µM -0.302613609188339 0.394204729449213 no 2072 0.381092170930638 2914 670149 SGTC_1907 st060210 83.7 µM -0.304646205348329 0.393536475916698 no 2073 0.380317812463882 3100 688793 SGTC_3187 9109394 49.47 µM -0.305000441778829 0.393420046167439 no 2074 0.380182907925431 2982 17098090 SGTC_662 k832-1615 104 µM -0.306925380661851 0.392787527808699 no 2075 0.379450084945112 3044 5878478 SGTC_1236 0330-0013 258 µM -0.308465501024764 0.392281661219273 no 2076 0.378864073696338 2995 4617066 SGTC_847 0342-0274 5.54 µM -0.310726736612149 0.391539267699189 no 2077 0.378004184913396 3073 18097 SGTC_1630 st005209 31.3 µM -0.311114992815204 0.391411837702832 no 2078 0.377856601872288 2995 3367314 SGTC_2936 9038235 15.59 µM -0.311661025215182 0.391232643528214 no 2079 0.37764907547984 2904 4749415 SGTC_677 0929-0063 136 µM -0.312049947734288 0.391105022960998 no 2080 0.377501282178801 2987 1539583 SGTC_3138 9097216 49.47 µM -0.312818347256802 0.390852915743644 no 2081 0.377209337681687 2923 25237486 SGTC_2778 tioconazole 65.09 nM -0.315141177901627 0.390091088413915 no 2082 0.376327232374349 2930 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2452 5863136 48.41 µM -0.315518762653224 0.389967290342516 no 2083 0.37618390375698 2917 2184096 SGTC_300 r073-0011 5.04 µM -0.315906187075501 0.389840277755114 no 2084 0.376036857815025 3058 2735780 SGTC_3038 9091290 49.47 µM -0.317500683685684 0.389317664560315 no 2085 0.375431860391734 3125 25236843 SGTC_256 clotrimazole 625 nM -0.317806201766334 0.389217550584171 no 2086 0.375315973045147 3034 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1748 st037455 53.6035 µM -0.319557568125499 0.38864379456223 no 2087 0.374651872328939 3147 580690 SGTC_442 cape 100 µM -0.320423219103119 0.388360292748685 no 2088 0.374323763184017 3098 5281787 SGTC_2208 7283366 200 µM -0.321117646840125 0.38813290974732 no 2089 0.374060618839569 3057 898663 SGTC_2106 5357045 167.29 µM -0.321430071432065 0.38803062212765 no 2090 0.373942248740237 3054 668842 SGTC_50 0929-0078 56.389 µM -0.321600148476734 0.38797494227239 no 2091 0.373877815669564 2956 1377751 SGTC_2693 st077581 40.7 µM -0.321641936402187 0.387961262085795 no 2092 0.373861985005032 3103 25238761 SGTC_450 aminopyrene 156 nM -0.322234574518983 0.38776726408055 no 2093 0.373637496772858 3097 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_943 3253-1379 105 µM -0.322811273694274 0.387578510523222 no 2094 0.373419087280378 3158 668464 SGTC_447 ml7 120 µM -0.323043700505029 0.387502444770464 no 2095 0.373331073291458 3046 4216 Selective myosin light chain kinase inhibitor. SGTC_1975 st070967 30.8 µM -0.323221667149569 0.387444204981708 no 2096 0.373263686418047 3144 261391 SGTC_1445 4239-0156 97.7 µM -0.324641185377646 0.38697975678955 no 2097 0.372726326330322 3155 4008346 SGTC_2355 9061122 103.12 µM -0.32574259587905 0.386619500797666 no 2098 0.37230955677242 3093 5302957 SGTC_2158 5657123 3.6195 µM -0.327577569287736 0.386019523709761 no 2099 0.371615542027963 2964 2858827 SGTC_2537 larixol 68.93 µM -0.327838440088466 0.385934249468166 no 2100 0.371516910549534 3004 6708759 SGTC_659 k018-0002 107 µM -0.328381026738156 0.385756904748779 no 2101 0.371311793404964 3108 6797879 YHR007C ERG11 SGTC_53 0973-0023 39.979 µM -0.332257733390212 0.384490498039949 no 2102 0.369847326257148 3081 674768 SGTC_1660 st012960 28.1 µM -0.332746883163424 0.384330794350987 no 2103 0.369662678260333 3086 24207266 SGTC_1455 4262-0120 131 µM -0.33296848711002 0.384258448804591 no 2104 0.369579035396835 3154 1529587 SGTC_2147 5545932 89.7195 µM -0.333146346960676 0.384200387014798 no 2105 0.369511907901378 3023 797404 SGTC_2311 7694451 200 µM -0.333880250152728 0.383960834117867 no 2106 0.369234961770012 3035 2163142 SGTC_474 dl-dihydrosphingosine 5 µM -0.337761760477309 0.382694611926573 no 2107 0.367771364377159 3144 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3205 9113483 49.47 µM -0.33797044175946 0.382626571509825 no 2108 0.367692731268832 3166 17018033 SGTC_1439 4092-1168 46 µM -0.339705444505257 0.382061015278961 no 2109 0.367039180606357 3072 2886240 SGTC_2921 7974240 10.71 µM -0.339954374307975 0.381979892614559 no 2110 0.366945443865801 3131 2979074 YDR527W RBA50 SGTC_2734 clemastine 41.6 µM -0.340115999638723 0.381927224003725 no 2111 0.366884586650651 3029 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3068 9116768 49.47 µM -0.34269806632517 0.381086106636599 no 2112 0.365912808791078 3111 41904888 SGTC_589 1227-0070 34.1 µM -0.343072488918529 0.380964183673551 no 2113 0.365771963594149 3121 2841384 SGTC_3230 9131665 49.47 µM -0.344084731828768 0.38063462692511 no 2114 0.365391282443691 2995 15943720 SGTC_1249 0481-0015 10.2 µM -0.34471431722882 0.380429695958421 no 2115 0.365154576780088 2978 4227577 SGTC_1141 3253-0389 52.6 µM -0.345107468698886 0.380301741595684 no 2116 0.365006789394546 3112 5402031 SGTC_2536 dehydroabietamide 32.04 µM -0.345450851287573 0.380189995637145 no 2117 0.364877726755854 3154 3983547 SGTC_1700 st030840 7.9285 µM -0.347366994131382 0.379566614892587 no 2118 0.364157813108785 3124 5499307 SGTC_3134 9127454 49.47 µM -0.347626506008889 0.379482211647727 no 2119 0.364060348732386 3132 24262820 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.347969078625161 0.37937080265057 no 2120 0.363931702858751 3017 6708630 An antioxidant. SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.348181371380949 0.379301767356874 no 2121 0.363851988515937 3029 689007 SGTC_472 calcifediol 10 µM -0.350044599309359 0.378696031259021 no 2122 0.363152613494688 3071 5283731 A vitamin D metabolite. SGTC_1032 k061-1018 98.7 µM -0.350198506716292 0.378646009201929 no 2123 0.363094863683328 3208 4005393 SGTC_3161 9100388 49.47 µM -0.350766159211876 0.378461531795065 no 2124 0.362881893547159 3035 25236368 SGTC_2987 9018338 71.43 µM -0.351156761395512 0.378334608811392 no 2125 0.362735373230837 3143 5055682 SGTC_3199 9111318 49.47 µM -0.35164992651314 0.378174377591623 no 2126 0.362550408836224 3133 8548020 SGTC_160 3453-0671 289.699 µM -0.351808369544773 0.378122903294263 no 2127 0.362490990677866 3017 5322268 SGTC_2440 5628896 157.78 µM -0.35215938869666 0.378008873393517 no 2128 0.362359365815806 3021 5522048 SGTC_1881 5652484 16 µM -0.35217918626242 0.378002442395809 no 2129 0.362351942626043 3155 2255129 SGTC_2725 haloperidol 53.21 µM -0.352589291131165 0.377869232438294 no 2130 0.362198183534145 3004 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_683 panaxydol 45 µM -0.35306586467755 0.377714450417836 no 2131 0.362019531518525 3042 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_210 3551-0445 56.827 µM -0.354230742672998 0.377336202898126 no 2132 0.361582983013574 3156 2865180 YOR207C RET1 SGTC_1815 st051655 58.2 µM -0.354310518304731 0.377310303253824 no 2133 0.36155309296152 3138 5984156 SGTC_1157 4092-0394 27.6 µM -0.354613518929961 0.377211937286225 no 2134 0.361439573456665 3214 3659885 SGTC_284 0988-0104 32.6 µM -0.355282535435334 0.376994776333751 no 2135 0.361188968923629 3108 4666532 SGTC_2217 6934799 96.0675 µM -0.356315041113048 0.376659704148492 no 2136 0.360802323187624 3115 675606 SGTC_2462 5162487 171.77 µM -0.360808226806523 0.375202645321065 no 2137 0.359121406201104 3113 2259986 SGTC_1124 fisetin 1.16336 µM -0.361140787606025 0.37509487232344 no 2138 0.358997101867201 3091 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1800 st050079 29.0735 µM -0.36278707657519 0.374561503124309 no 2139 0.358381973268918 3137 3645560 SGTC_1006 4099-6547 255 µM -0.362890951461973 0.374527857490667 no 2140 0.358343173179369 3140 3146833 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.364008346636159 0.374165987653175 no 2141 0.357925888315159 3167 1377 SGTC_1798 st045719 60.953 µM -0.364050228247717 0.374152426393674 no 2142 0.357910251162378 3135 3980186 SGTC_3165 9101544 49.47 µM -0.365094702944323 0.373814276054826 no 2143 0.357520357422018 3143 5002184 SGTC_709 3807-1509 243 µM -0.365311884944976 0.373743975223886 no 2144 0.357439303838827 3094 1886677 YPL242C IQG1 SGTC_1771 st048882 4.1505 µM -0.366200163141698 0.37345648733608 no 2145 0.357107860231245 3033 4580403 SGTC_2715 st079500 56.4 µM -0.366777785465232 0.37326957982156 no 2146 0.356892389602608 3019 28246688 SGTC_3031 9088762 49.47 µM -0.367229332403199 0.373123488647587 no 2147 0.356723980697546 2994 205253 SGTC_982 1491-0518 27.5 µM -0.367965143207093 0.372885467291072 no 2148 0.356449612604962 3046 3091256 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.368094472137364 0.372843636755007 no 2149 0.35640139628739 3073 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2663 amphotericin b 100 µM -0.368754570139842 0.372630156047881 no 2150 0.356155334800892 3099 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1744 st037937 38.9 µM -0.369867068034095 0.372270454334074 no 2151 0.355740769997717 3251 1016152 SGTC_1976 st070609 63.5 µM -0.371547333170826 0.371727388868762 no 2152 0.355114954040097 3002 682556 SGTC_777 1315-0167 517 µM -0.371846953158517 0.371630577790989 no 2153 0.355003401349079 3123 4221767 SGTC_507 nimesulide 162 µM -0.374788123478291 0.370680679638557 no 2154 0.353909023820612 3260 4495 A COX2 inhibitor. SGTC_2779 methotrexate 400 µM -0.375860864314683 0.370334416514593 no 2155 0.353510168251409 3161 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2934 9036370 36.88 µM -0.376196413201009 0.370226128398809 no 2156 0.353385440876861 3150 6462800 SGTC_3057 9095946 49.47 µM -0.376964911665987 0.369978157844262 no 2157 0.353099840510407 3040 24540043 SGTC_88 0180-0332 8.668 µM -0.377140018183681 0.369921663973242 no 2158 0.353034776494435 3052 3101745 SGTC_2967 9089538 49.85 µM -0.378342145047863 0.369533902735622 no 2159 0.352588220452375 3272 728216 SGTC_1008 4106-0037 6 µM -0.380719426244401 0.368767471495867 no 2160 0.35170572625295 2999 2905394 SGTC_1620 st003704 16.5 µM -0.381258896249636 0.368593619833758 no 2161 0.351505575214907 3207 2834414 SGTC_602 3130-1533 38.1 µM -0.381280577103595 0.368586633440936 no 2162 0.351497532170045 3179 720941 SGTC_2152 5568786 200 µM -0.381586788723052 0.36848796509228 no 2163 0.351383942557185 3123 5399883 SGTC_401 neomycin 50 µM -0.382314602908187 0.368253481615385 no 2164 0.351114012181923 3112 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_3299 9121982 43.1275 µM -0.382531785258635 0.368183520410426 no 2165 0.351033478537461 3089 17594604 YPL160W CDC60 SGTC_678 1218-2179 85.9 µM -0.38300615521189 0.368030726265043 no 2166 0.350857600123617 3140 6820081 YOR116C RPO31 SGTC_2595 hexamethylquercetagetin 100 µM -0.383361440994198 0.367916302697962 no 2167 0.350725894535704 3122 386331 SGTC_2667 digitoxin 100 µM -0.38495838801562 0.367402133775152 no 2168 0.350134122828898 3161 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2655 perillic acid 100 µM -0.385896163286745 0.367100309021202 no 2169 0.349786786110152 3099 5702197 An apoptosis inducer. SGTC_2031 5180455 200 µM -0.386112554780753 0.367030674661036 no 2170 0.349706656053569 3069 29949 SGTC_2516 gossypol 71.55 µM -0.387624736527643 0.366544179736723 no 2171 0.349146880187882 3214 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1804 st050076 49.1 µM -0.388831134263182 0.366156214466377 no 2172 0.348700533904637 3188 3895976 SGTC_930 2810-3379 265 µM -0.389729582999779 0.365867371312453 no 2173 0.348368259386331 3286 1015764 SGTC_182 3448-4371 550.524 µM -0.389961947911972 0.365792680457596 no 2174 0.348282342478791 3156 3491403 SGTC_1310 1188-0297 994 nM -0.389975857916948 0.365788209418225 no 2175 0.348277199502494 3111 1588352 SGTC_3335 9143315 29.6265 µM -0.39227199216163 0.365050422115503 no 2176 0.347428627836558 3110 4899691 SGTC_1841 st054148 70 µM -0.392445204610796 0.364994786205457 no 2177 0.34736464545855 3163 675442 SGTC_2067 5224629 34.075 µM -0.392889970154671 0.3648519403504 no 2178 0.34720037489957 3236 2835000 SGTC_233 rapamycin 362 pM -0.396170697379518 0.363798846115744 no 2179 0.345989553334362 3165 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_218 alverine citrate 93.75 µM -0.396226972021238 0.363780791230995 no 2180 0.345968797679592 3225 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_638 3970-0837 4.09 µM -0.396454838930718 0.363707686602605 no 2181 0.345884758750214 3114 4118451 YLR208W SEC13 SGTC_2125 5246583 200 µM -0.39646902924091 0.363703134208551 no 2182 0.345879525514422 3275 835267 SGTC_1028 k015-0029 4.8 µM -0.397275829523665 0.363444336239137 no 2183 0.345582034584196 3082 4588309 SGTC_3220 9131269 49.47 µM -0.397510849536949 0.363368960396437 no 2184 0.345495393734908 3184 17722206 SGTC_2600 tangeritin 87.95 µM -0.399797334870119 0.362635913128784 no 2185 0.344652896930266 3070 68077 A bioactive flavone. SGTC_2420 aureobasidin a 50 nM -0.402256924444195 0.361847930441195 no 2186 0.343747476272328 3345 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1148 3909-7663 27.7 µM -0.404606355425755 0.361095785937822 no 2187 0.3428834430909 3224 4084526 SGTC_644 1498-1197 63.3 µM -0.404714241943362 0.361061260122783 no 2188 0.34284378613364 3211 6741615 SGTC_2377 9073351 62.6 µM -0.404747495136506 0.361050618672842 no 2189 0.34283156326439 3096 7337946 YHR072W ERG7 SGTC_2534 helenine 20.12 µM -0.404807824125724 0.361031312894098 no 2190 0.34280938857041 3078 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1375 2910-0797 186 µM -0.405845569333489 0.360699281246154 no 2191 0.342428036837491 3146 742508 SGTC_755 1995-0008 37.3 µM -0.406209943324186 0.360582722897226 no 2192 0.342294174360765 3237 689533 SGTC_357 1325-0123 420 µM -0.406862042935448 0.360374157321897 no 2193 0.342054657689412 3228 1098503 SGTC_544 k015-0020 52.4 µM -0.407850198517481 0.360058187801914 no 2194 0.34169182853105 3155 3008304 SGTC_2853 9015042 58.44 µM -0.408153159457029 0.359961333100678 no 2195 0.341580617156757 3014 6457456 SGTC_794 k038-0031 316 µM -0.408759464643589 0.359767528162192 no 2196 0.341358095007896 3229 6624242 SGTC_1483 3453-0561 55.9 µM -0.409201519986525 0.359626248269282 no 2197 0.341195889512258 3199 4546991 SGTC_1914 st062367 72.6 µM -0.409246073189538 0.359612010229635 no 2198 0.341179543017978 3101 978205 SGTC_3140 9094243 49.47 µM -0.409469981720045 0.35954045786426 no 2199 0.341097395872989 3216 19291112 SGTC_2962 9082311 13.18 µM -0.410100580536403 0.359338969738465 no 2200 0.340866083436682 3075 16459453 SGTC_3248 9135562 49.47 µM -0.411797368918091 0.358797008417175 no 2201 0.340243975012337 3169 17650701 SGTC_2835 9006588 71.43 µM -0.412413313478341 0.3586003433828 no 2202 0.34001825327105 3304 2345538 SGTC_1276 0871-0068 94.2 µM -0.412732486895029 0.358498449196202 no 2203 0.339901310129695 3196 3414906 SGTC_93 0109-0045 59.227 µM -0.416134280692915 0.357413074176155 no 2204 0.338655873179015 3221 88733 SGTC_3192 9110362 49.47 µM -0.418795382498629 0.356564826852671 no 2205 0.337682839875721 3214 16649480 SGTC_371 0195-0006 7.36 µM -0.419646077848891 0.356293810301791 no 2206 0.337372011004997 3105 3928593 SGTC_3348 9149464 3.537 µM -0.42319602423898 0.355163644573451 no 2207 0.336076123638199 3185 1951442 SGTC_2088 5278280 127.392 µM -0.426024364862375 0.35426412068393 no 2208 0.335045046034579 3249 791502 SGTC_1027 k015-0025 8.67 µM -0.426228123219898 0.354199348804408 no 2209 0.334970813357343 3118 3598955 SGTC_1246 0422-0085 105 µM -0.426419552144941 0.354138500118548 no 2210 0.334901078377874 3296 264295 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.427366836643361 0.353837445725763 no 2211 0.334556079209922 3179 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1262 0737-0114 49.6 µM -0.427769140807482 0.35370961795978 no 2212 0.334409603047924 3321 765919 SGTC_1289 0976-0073 69.1 µM -0.42799119291354 0.35363907038463 no 2213 0.334328766207066 3254 3391136 SGTC_1316 1272-0050 65.9 µM -0.429866332334235 0.35304352556519 no 2214 0.333646438740483 3188 7340392 SGTC_381 3461-2219 42.7 µM -0.430430440264792 0.352864435058265 no 2215 0.333441278109456 3244 2883159 SGTC_1868 st057644 42.7 µM -0.431684693142295 0.352466357222509 no 2216 0.332985296965318 3117 688665 SGTC_2822 7994718 71.43 µM -0.432343287714958 0.352257395523219 no 2217 0.332745965006486 3189 1018011 SGTC_967 1306-0166 352 µM -0.432653194666802 0.352159082347057 no 2218 0.332633369005899 3305 4437607 SGTC_2263 7948595 193.29 µM -0.43306094985654 0.352029743386737 no 2219 0.33248524559143 3134 2971371 SGTC_2449 5812982 45.77 µM -0.433089298646454 0.352020751855356 no 2220 0.332474948424721 3247 776185 SGTC_1690 st023502 41.2 µM -0.433607490032397 0.351856409014381 no 2221 0.332286747397133 3258 24207482 SGTC_3131 9127911 49.47 µM -0.433817327727858 0.35178986749032 no 2222 0.332210548835094 3377 45595681 SGTC_236 1509-0011 5.31 µM -0.43433854926414 0.351624602842983 no 2223 0.332021307180472 3323 3107280 SGTC_1827 berberine 7.24 µM -0.4374564532386 0.350636589908479 no 2224 0.330890175299571 3152 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_938 3126-1755 342 µM -0.43793580164538 0.350484781574524 no 2225 0.330716410926302 3321 1777771 SGTC_20 0481-0013 4.944 µM -0.437946635136979 0.350481350913093 no 2226 0.330712484193935 3232 182045 SGTC_1755 st041960 45.185 µM -0.438621860211349 0.350267550243795 no 2227 0.330467777337609 3282 2257073 SGTC_340 k038-0059 454 µM -0.438755744802318 0.35022516317589 no 2228 0.330419265118776 3246 23733424 SGTC_2359 9039622 200 µM -0.438971615416816 0.350156823748081 no 2229 0.330341051794389 3147 6463596 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.439247852609939 0.350069380795205 no 2230 0.330240977517717 3312 688798 SGTC_2361 9034121 116 µM -0.43964659448924 0.349943172972927 no 2231 0.330096544071909 3185 6496917 SGTC_3163 9099914 49.47 µM -0.439874749028652 0.349870966072799 no 2232 0.330013912656122 3253 16268368 SGTC_2971 9092186 9.93 µM -0.439944119041928 0.349849012759511 no 2233 0.329988790353549 3120 25236400 SGTC_510 ag-490 170 µM -0.441095747047314 0.349484633997766 no 2234 0.329571841152783 3297 5328779 SGTC_2135 5326629 150.42 µM -0.441389670226909 0.349391657965257 no 2235 0.329465459583675 3184 5020077 SGTC_1468 k284-1086 134 µM -0.441787784032433 0.34926573796483 no 2236 0.329321389616109 3220 15996457 SGTC_3224 9130643 49.47 µM -0.442682551357048 0.348982791255962 no 2237 0.328997682488404 3349 17644395 SGTC_199 4063-0024 41.6 µM -0.444853126630658 0.348296752813394 no 2238 0.328212949218775 3292 306215 SGTC_1189 1431-2119 7.28 µM -0.445008851850764 0.348247552884114 no 2239 0.328156678589419 3280 3107275 SGTC_2267 7931562 200 µM -0.446393082570389 0.347810330433587 no 2240 0.327656664361454 3124 934880 SGTC_3 0833-0587 95.581 µM -0.447469870707469 0.347470356508486 no 2241 0.327267918624371 3242 5382644 SGTC_1570 verbenone 133 µM -0.44804764365839 0.347287987013068 no 2242 0.327059406231776 3344 29025 A natural terpanoid with antifungal properties. SGTC_2791 5663188 71.43 µM -0.449817690057448 0.3467295059666 no 2243 0.326420950633576 3326 54690634 SGTC_2540 epiandrosterone 100 µM -0.449925930173704 0.346695365078133 no 2244 0.326381924902429 3259 441302 A steroid. SGTC_2640 pentamidine 10.38 µM -0.451333770410038 0.346251420322556 no 2245 0.325874504512355 3280 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2654 protoveratrine a 100 µM -0.452385527426953 0.345919899712197 no 2246 0.325495635605495 3214 5702278 A heart drug and vasodilator. SGTC_1078 idebenone 36.1 µM -0.45409721680034 0.345380616707791 no 2247 0.324879428203412 3266 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1638 st008370 60.6 µM -0.456117226899988 0.344744598141861 no 2248 0.324152841492279 3267 24207134 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.456673326955987 0.34456958188428 no 2249 0.323952932671381 3161 23665772 A membrane-active detergent. SGTC_724 3910-0327 137 µM -0.457167089579491 0.344414212393878 no 2250 0.323775475675493 3279 2885483 SGTC_1979 st071809 45.3 µM -0.458108839032891 0.34411795021847 no 2251 0.323437124461532 3338 4976333 SGTC_1063 disulfiram 1.84 µM -0.458368987125762 0.344036127852776 no 2252 0.323343684316552 3234 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1399 3562-5772 25 µM -0.460040885697034 0.343510452948421 no 2253 0.322743436908628 3208 23847490 SGTC_877 0771-0151 33.1 µM -0.460272393950787 0.343437686423427 no 2254 0.322660356831722 3265 6166523 SGTC_2738 aclarubicin 5.55 µM -0.463020956256279 0.342574216012348 no 2255 0.321674672997003 3230 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_783 0848-0141 92.7 µM -0.464295038386657 0.342174237222867 no 2256 0.321218189136265 3263 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1400 3771-8998 51.5 µM -0.464753820202528 0.342030252940776 no 2257 0.321053880803985 3215 670767 SGTC_66 0109-0187 42.4 µM -0.466301996783383 0.341544542174287 no 2258 0.320499674842251 3329 759417 SGTC_2402 5553605 200 µM -0.466741444290799 0.341406721686095 no 2259 0.320342437173313 3387 6758546 SGTC_1420 4'-methoxyflavone 42 µM -0.468004436297576 0.341010737151364 no 2260 0.319890708610019 3308 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_172 1112-0046 2.638 µM -0.469600733360897 0.34051050233463 no 2261 0.319320150317074 3199 2802135 YIL048W NEO1 SGTC_752 1896-0090 130 µM -0.471647602249965 0.339869481339267 no 2262 0.318589171624825 3290 772567 SGTC_856 0433-0016 11.3 µM -0.472423402692772 0.339626643581764 no 2263 0.31831230164328 3306 3911780 SGTC_2201 6605497 169.863 µM -0.473068090123701 0.339424896892209 no 2264 0.318082300845138 3266 670741 SGTC_71 0417-1750 47.813 µM -0.473206320327967 0.339381645505617 no 2265 0.318032994513633 3359 6811472 SGTC_1419 3993-2473 62.6 µM -0.474507687530476 0.338974559449293 no 2266 0.317568958638176 3284 704026 SGTC_275 trichlorophene 5.69 µM -0.475848446203716 0.338555347753222 no 2267 0.31709117632453 3333 62616 SGTC_2747 doxorubicin 7.63 µM -0.476031481575198 0.338498134037918 no 2268 0.317025974890562 3230 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2165 5727197 32.143 µM -0.479799773543847 0.337321060677494 no 2269 0.315684886954932 3523 1361712 SGTC_2249 haloperidol 116.36 µM -0.481536021949115 0.336779256135859 no 2270 0.315067792233277 3308 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3316 9136639 10.545 µM -0.482851274484558 0.336369050653451 no 2271 0.314600670440165 3341 4903665 SGTC_3001 9076041 71.4286 µM -0.482920032637458 0.33634761147567 no 2272 0.31457625861857 3269 16004211 SGTC_107 0358-0022 2.6945 µM -0.484465626311421 0.335865827236672 no 2273 0.314027726747212 3305 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1619 st003326 88.7 µM -0.484571192983881 0.335832930382282 no 2274 0.313990276056943 3359 2849032 SGTC_1334 1486-0610 236 µM -0.484960515075294 0.335711620087674 no 2275 0.313852177239842 3331 3742339 SGTC_3252 9135871 49.47 µM -0.486220735967669 0.335319060694843 no 2276 0.313405335454393 3366 17682838 SGTC_3213 9129884 49.47 µM -0.487909192928742 0.334793387365591 no 2277 0.312807081350588 3310 17190742 SGTC_713 1488-1073 324 µM -0.488019797617383 0.334758963694809 no 2278 0.312767909073751 3334 3312542 SGTC_499 genistein 192 µM -0.489277874447217 0.334367508256437 no 2279 0.312322491556853 3345 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1475 4092-1048 11.7 µM -0.491520070382118 0.333670286960428 no 2280 0.311529330162783 3365 2881759 SGTC_1854 st056233 32.9 µM -0.492469489716063 0.333375233424417 no 2281 0.31119374271324 3340 5393174 SGTC_2317 5986382 200 µM -0.492929931453897 0.333232177838806 no 2282 0.311031048688807 3320 877883 SGTC_372 0155-0182 15.9 µM -0.493075207946229 0.333187046621547 no 2283 0.310979723868099 3283 771486 SGTC_2569 tetrandrine 100 µM -0.49609220616826 0.332250340582641 no 2284 0.309914678891815 3256 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_598 3937-0236 20.2 µM -0.496474197915985 0.332131815803015 no 2285 0.309779943612492 3349 1379313 SGTC_2493 resveratrol 26.09 µM -0.498527405886618 0.33149503232518 no 2286 0.309056178779434 3342 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1724 st037281 8.293 µM -0.498529545066871 0.331494369131718 no 2287 0.309055425094726 3268 574124 YDL195W SEC31 SGTC_565 1418-0001 44.5 µM -0.500719569056363 0.330815690432003 no 2288 0.308284249000483 3418 2862145 SGTC_504 lovastatin 124 µM -0.500818680488099 0.330784989367451 no 2289 0.308249368728435 3310 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2992 9074591 71.4286 µM -0.502715772448553 0.330197559880433 no 2290 0.307582059449266 3393 17741321 SGTC_1659 st012954 42.1 µM -0.503437068159953 0.329974322255375 no 2291 0.307328507760651 3383 24207262 SGTC_848 0368-0089 85.6 µM -0.506494006932253 0.329028886815413 no 2292 0.306254947905625 3366 762535 SGTC_2167 5876490 200 µM -0.506938868792258 0.328891392994856 no 2293 0.306098856074755 3426 686534 SGTC_427 1354-0053 47.3 µM -0.508456947238262 0.32842237363807 no 2294 0.305566462271892 3450 6813657 SGTC_1821 st053465 65.6 µM -0.509358406932291 0.328143990145294 no 2295 0.305250512496742 3330 675086 SGTC_153 4077-0274 519.67 µM -0.509409903166758 0.328128090260248 no 2296 0.305232468120948 3512 3121976 SGTC_266 formosanin C 406 nM -0.510190891213693 0.327886991979501 no 2297 0.304958866510903 3353 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_3133 9127736 49.47 µM -0.511959663118498 0.327341220881281 no 2298 0.304339620177898 3426 27243420 SGTC_1864 st057645 30.4 µM -0.511991926237672 0.327331269216515 no 2299 0.3043283300736 3416 688666 SGTC_723 4182-0001 115 µM -0.512890176113022 0.327054250393558 no 2300 0.30401407285636 3309 744821 YLR208W SEC13 SGTC_1951 sophoraflavanone G 9.2 µM -0.51364584211962 0.32682127797725 no 2301 0.303749811417185 3290 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1756 st041558 35.5 µM -0.515630485641363 0.326209732441716 no 2302 0.303056256990904 3450 3955792 SGTC_2374 9071832 200 µM -0.516563324342606 0.325922449943113 no 2303 0.302730511707541 3399 17381698 SGTC_2407 paclitaxel 400 µM -0.516690232502743 0.325883374538914 no 2304 0.302686207771245 3432 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1861 st057647 17.4 µM -0.517161373301098 0.325738325601461 no 2305 0.302521756829139 3434 688668 SGTC_3078 9116413 49.47 µM -0.518615155772964 0.325290919576306 no 2306 0.302014569046343 3296 17177322 SGTC_2877 9040724 71.43 µM -0.519255714358314 0.32509386554885 no 2307 0.301791215696308 3427 6463895 SGTC_3022 9087993 49.47 µM -0.519403712245423 0.325048344146067 no 2308 0.301739621572416 3391 17173644 SGTC_1443 4112-3303 14 µM -0.519521799298746 0.325012024633596 no 2309 0.301698457626193 3360 704433 SGTC_2148 5546263 113.568 µM -0.51954983473927 0.32500340214145 no 2310 0.301688685127578 3281 792097 SGTC_599 1935-0052 86.5 µM -0.522014420464265 0.324245768629072 no 2311 0.300830145121177 3290 9557311 SGTC_626 0214-0009 33 µM -0.52413947928204 0.323593092011254 no 2312 0.30009076560538 3413 3437874 SGTC_309 k408-0051 1.48 µM -0.524955685979338 0.323342551672267 no 2313 0.29980699845982 3379 3640463 SGTC_2718 lomofungin 53.02 µM -0.525659094656407 0.323126699716807 no 2314 0.299562544844001 3436 5351222 A RNA synthesis inhibitor. SGTC_2905 7799065 20.05 µM -0.526024343707588 0.323014640813492 no 2315 0.299435646521082 3409 1296806 SGTC_3322 9139058 2.11 µM -0.527816873231282 0.322464923340363 no 2316 0.298813222386168 3441 4908926 YPR165W RHO1 SGTC_1191 1487-1166 10.6 µM -0.528478255166302 0.322262194347227 no 2317 0.298583717799267 3417 3955771 SGTC_725 1497-0963 19 µM -0.529290929435085 0.322013163104716 no 2318 0.298301823446026 3429 3549977 SGTC_3174 9107204 49.47 µM -0.530523844778872 0.321635508182767 no 2319 0.297874390534539 3443 3938802 SGTC_1693 xanthone 101.9 µM -0.534120892686751 0.320534748609296 no 2320 0.296628947880934 3373 7020 An insecticide. SGTC_1862 st057513 3.81 µM -0.537047351405148 0.319640363540447 no 2321 0.295617453219303 3305 5393163 SGTC_796 1234-0020 70.7 µM -0.537865984716462 0.319390359959013 no 2322 0.295334786688019 3398 46495034 SGTC_1497 4476-2978 41.3 µM -0.538136270627423 0.319307834982489 no 2323 0.295241486774013 3423 1528379 SGTC_1526 st051518 75 µM -0.539481268878408 0.318897306898584 no 2324 0.294777409090409 3319 673993 SGTC_3280 9140961 49.47 µM -0.540070307611617 0.318717587015572 no 2325 0.294574273345801 3308 4901226 SGTC_1416 3966-0321 25.3 µM -0.540669364196631 0.318534854337126 no 2326 0.29436774911708 3392 582530 YLR208W SEC13 SGTC_841 0251-0215 91.2 µM -0.54104844404794 0.318419244855333 no 2327 0.294237096221077 3401 3888614 SGTC_975 1335-0046 28.5 µM -0.541902287472569 0.318158909620656 no 2328 0.293942910435081 3357 16486740 SGTC_2743 auranofin 4.32 µM -0.54204238202492 0.318116203631362 no 2329 0.293894654828048 3333 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1401 3807-4679 7.6 µM -0.543059593042615 0.317806192723452 no 2330 0.293544386149066 3419 3291456 SGTC_2914 7968218 45.32 µM -0.543500716610927 0.317671793116097 no 2331 0.293392548806341 3392 2977111 SGTC_1233 0325-0408 14.2 µM -0.543787999901396 0.317584277810356 no 2332 0.293293683767704 3436 12874 SGTC_2680 butyl paraben 22.24 µM -0.546836077610899 0.31665636840117 no 2333 0.292245677341525 3440 7184 An antifungal and steroid mimetic. SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.547043406113206 0.316593294334056 no 2334 0.292174455863687 3417 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1300 1094-0077 113 µM -0.549885227937641 0.315729285368097 no 2335 0.291199048404105 3383 5532636 SGTC_2723 salbutamol 83.58 µM -0.549930458629896 0.315715541845091 no 2336 0.291183536029961 3412 9884233 β2-adrenoceptor agonist SGTC_1345 1488-0192 31.4 µM -0.552502163133567 0.314934538972001 no 2337 0.290302176396359 3475 658348 SGTC_2453 5731132 22.18 µM -0.5527983916635 0.31484463014764 no 2338 0.290200734973548 3485 1362040 SGTC_1996 st072960 66.8 µM -0.555056860948732 0.314159519354786 no 2339 0.289427884211009 3486 1719405 SGTC_1114 scopoletin 1.73284 µM -0.555646729674296 0.313980686886498 no 2340 0.289226189814837 3475 5280460 A coumarin with genotoxic properties. SGTC_3008 9078912 71.4286 µM -0.557845805926065 0.313314370824274 no 2341 0.28847484041476 3423 16648731 SGTC_1572 epiandrosterone 68.9 µM -0.558147731710443 0.31322293536089 no 2342 0.288371754526511 3430 441302 A steroid. SGTC_869 0564-0080 44.1 µM -0.560056594622426 0.312645119633324 no 2343 0.287720417797255 3409 6843321 SGTC_885 0865-0106 16.8 µM -0.560429114938575 0.312532410783499 no 2344 0.287593388593483 3432 2793380 SGTC_3278 9139605 49.47 µM -0.560801988073417 0.312419612742351 no 2345 0.28746626563371 3512 7958859 SGTC_652 0437-0092 114 µM -0.561601827017771 0.312177712348289 no 2346 0.287193667670952 3461 3091274 SGTC_286 k060-0067 22.9 µM -0.564012924585978 0.311448998878468 no 2347 0.28637266810935 3412 5985051 SGTC_2344 7990960 76.95 µM -0.566555134499742 0.310681458177824 no 2348 0.285508232090409 3386 140813 SGTC_115 0527-0192 112.043 µM -0.568422448973142 0.310118205215329 no 2349 0.284874075335671 3476 4233931 SGTC_530 4358-1714 28 µM -0.568924281219468 0.309966909401278 no 2350 0.28470376323251 3468 1564641 SGTC_1059 3448-6867 171 µM -0.570933841172254 0.309361376123729 no 2351 0.284022245116108 3478 3934407 SGTC_424 splitomicin 100 mM -0.571968754215939 0.309049731301389 no 2352 0.283671571532228 3443 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2471 5466956 24.79 µM -0.572242882916633 0.308967205544737 no 2353 0.283578719549883 3382 724419 SGTC_597 k018-0003 82.8 µM -0.572895298297036 0.308770836319182 no 2354 0.283357794121003 3508 6786234 SGTC_696 1560-0013 611 µM -0.572996016934437 0.308740526083244 no 2355 0.2833236954311 3550 1650269 SGTC_660 4031-1742 102 µM -0.573848938874473 0.308483900262852 no 2356 0.28303501427632 3420 6738706 SGTC_2394 5221648 200 µM -0.578170006183362 0.307185223626466 no 2357 0.281574673342611 3502 788586 SGTC_2546 rhodinyl acetate 100 µM -0.579063898446491 0.306916869359946 no 2358 0.281273029222352 3493 6708682 SGTC_2142 5622915 118.518 µM -0.580246653510074 0.306561954920321 no 2359 0.280874148231322 3460 5322196 SGTC_3196 9111891 49.47 µM -0.581589796036732 0.306159132206705 no 2360 0.280421508849637 3499 18891510 SGTC_3298 9116858 71.43 µM -0.58194788627656 0.306051776670833 no 2361 0.280300891999688 3500 2506942 SGTC_1365 1672-3266 55.4 µM -0.583338794458358 0.305634940144456 no 2362 0.27983262578758 3503 6415873 SGTC_3185 9108267 49.47 µM -0.583900581871712 0.305466651338111 no 2363 0.279643600841121 3477 4910486 SGTC_1175 0741-0056 27.6 µM -0.586013347617746 0.304834120230598 no 2364 0.278933272605141 3556 765927 SGTC_322 k048-0136 19.3 µM -0.586169652894295 0.304787347853871 no 2365 0.278880756450025 3501 6823282 SGTC_2490 carminic acid 95.39 µM -0.587065846255522 0.304519234929906 no 2366 0.278579742247705 3477 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_178 4092-0806 87.505 µM -0.588550367129329 0.304075343938859 no 2367 0.278081468521605 3501 2169044 SGTC_883 0850-0245 24.6 µM -0.589727368316352 0.303723610423275 no 2368 0.277686721841827 3550 6823229 YPR165W RHO1 SGTC_2409 alverine citrate 63.97 µM -0.58975138810706 0.30371643427088 no 2369 0.277678668853019 3584 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2888 9058547 12.99 µM -0.590425498137465 0.303515068036108 no 2370 0.277452710067756 3434 16476514 SGTC_996 3970-0799 1.8 µM -0.591227878363209 0.303275463431765 no 2371 0.277183872877949 3556 6615648 YGL040C HEM2 SGTC_75 0159-0059 199.013 µM -0.591583569809855 0.303169274874149 no 2372 0.277064739375899 3628 5377270 SGTC_51 1013-0126 23.419 µM -0.594027337731904 0.302440159440796 no 2373 0.276246914267415 3620 1627850 SGTC_1168 k815-0004 80.5 µM -0.594672988478907 0.302247656370569 no 2374 0.276031040437633 3468 642433 SGTC_3002 9075603 71.4286 µM -0.595640401440651 0.301959321711237 no 2375 0.275707740285702 3494 20105405 SGTC_912 3474-0017 2.18 µM -0.59579129748615 0.301914358719437 no 2376 0.275657329057157 3544 3360550 SGTC_2087 5276107 200 µM -0.596480987602404 0.301708887789653 no 2377 0.275426975647434 3497 144405 SGTC_460 trequinsin 123 µM -0.596556723317668 0.301686328607283 no 2378 0.275401686029747 3534 5537 A vasodilator. SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.597067871929715 0.301534094060988 no 2379 0.275231033521347 3564 688801 SGTC_1080 nisoldipine 24.4 µM -0.598866331375942 0.300998736815954 no 2380 0.274631012453845 3452 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2386 9075165 157.42 µM -0.600811761357617 0.300420113001192 no 2381 0.273982684787198 3485 16452277 SGTC_1730 st033808 45.1 µM -0.604029317802721 0.299464228722372 no 2382 0.272912075255348 3466 1045166 SGTC_2483 5729050 27.16 µM -0.605907923181162 0.29890676360461 no 2383 0.272287948913843 3576 2865180 SGTC_186 3455-3465 67.277 µM -0.607519753501297 0.298428838520968 no 2384 0.271753018744043 3497 755278 SGTC_1196 1588-0294 184 µM -0.607764002038361 0.298356446544475 no 2385 0.271672003815489 3504 6144269 SGTC_342 k048-0088 23.3 µM -0.610824879899119 0.297449922151327 no 2386 0.270657760207512 3493 6820570 SGTC_1794 st048918 76.9 µM -0.610837962841131 0.297446050144937 no 2387 0.270653429143685 3492 672303 SGTC_1945 st075991 56.6 µM -0.61217908438792 0.297049256160739 no 2388 0.270209639089023 3462 1084980 SGTC_2291 7917025 104.35 µM -0.614310829888344 0.296419041143427 no 2389 0.269504973698477 3491 2964612 SGTC_2887 9044784 58.44 µM -0.617308726258388 0.295533801576971 no 2390 0.268515556081209 3551 6465546 SGTC_294 k038-0071 157 µM -0.621930014857694 0.294171582143469 no 2391 0.26699394389711 3547 24152826 SGTC_1901 st060216 58.6 µM -0.622107761217811 0.294119245752246 no 2392 0.266935505958749 3562 688792 SGTC_3181 9108277 49.47 µM -0.62486954308289 0.293306608441622 no 2393 0.266028341662204 3502 17097298 SGTC_207 4185-0010 4.486 µM -0.62503276674698 0.293258613468028 no 2394 0.265974776391381 3611 3761753 SGTC_1003 4049-0218 100 µM -0.627478248587686 0.292539969956677 no 2395 0.265172894933145 3600 295161 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.627765263586711 0.292455679750021 no 2396 0.265078862344852 3547 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_346 4513-0042 7.16 µM -0.62912395270148 0.292056814929049 no 2397 0.264633955138577 3574 2827372 SGTC_2724 maprotiline 69.64 µM -0.632164782390429 0.2911650497512 no 2398 0.263639603647654 3565 4011 A tricyclic antidepressant. SGTC_3242 9133940 49.47 µM -0.632556353879571 0.291050308486427 no 2399 0.263511698414871 3610 17248444 SGTC_2001 4023502 57.655 µM -0.63257566439414 0.291044650518688 no 2400 0.26350539153341 3556 108941 YCR052W RSC6 SGTC_1166 k206-0078 225 µM -0.632761199843783 0.290990291375708 no 2401 0.263444798934196 3567 5404595 SGTC_647 0140-0236 81 µM -0.63532154219414 0.290240633796302 no 2402 0.262609363278183 3584 990837 SGTC_1358 1509-0022 2.48 µM -0.636173459879459 0.289991396589632 no 2403 0.262331684793375 3574 3258434 SGTC_2839 9003951 25.97 µM -0.636648319813054 0.289852515041853 no 2404 0.262176971770617 3560 2990634 SGTC_74 000s-0487 160.283 µM -0.636824767998323 0.289800917466381 no 2405 0.262119495509166 3553 677548 SGTC_601 0986-0029 62.9 µM -0.641797631788008 0.288348511080216 no 2406 0.260502293757746 3587 24747981 SGTC_1377 2944-0135 198 µM -0.644766848934636 0.287482942113514 no 2407 0.259539144067659 3626 1894137 SGTC_1273 0849-0096 14.1 µM -0.645611161932653 0.287237037439065 no 2408 0.259265603401255 3584 5286025 SGTC_820 1582-0060 59.9 µM -0.645642522387427 0.287227905679596 no 2409 0.25925544610638 3551 3848840 SGTC_1970 st070122 35.8 µM -0.646213124755687 0.287061777637376 no 2410 0.259070670403711 3630 102928 SGTC_785 1270-0111 65.3 µM -0.648003401000118 0.286540843171541 no 2411 0.258491375285711 3581 6741994 SGTC_3276 9139060 49.47 µM -0.648398995081796 0.286425793757123 no 2412 0.258363460065073 3640 4870619 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.648576413379383 0.286374202859059 no 2413 0.258306102570151 3441 4000243 SGTC_737 1950-0117 57.9 µM -0.65264971934991 0.285190954127786 no 2414 0.256991062239902 3582 5393513 SGTC_2703 st077852 53.4 µM -0.653273442265561 0.285009975663439 no 2415 0.256790005276321 3599 6281836 SGTC_1682 st012968 530 nM -0.653967381522468 0.284808687717173 no 2416 0.256566410346795 3543 24207270 SGTC_1529 apigenin 74 µM -0.654103019360648 0.2847693517652 no 2417 0.256522718180552 3669 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3202 9113761 49.47 µM -0.654148334549665 0.28475621061116 no 2418 0.256508121946689 3611 4798415 SGTC_2279 7948423 32.93 µM -0.654632108688039 0.284615936828778 no 2419 0.256352323007956 3621 1247112 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.654750300312582 0.284581671334944 no 2420 0.256314267020711 3581 521171 SGTC_3225 9130819 49.47 µM -0.655183219579631 0.284456178484776 no 2421 0.256174898452414 3611 4547121 SGTC_3009 9080819 71.4286 µM -0.656114052780888 0.284186441965947 no 2422 0.2558753716274 3598 17027216 SGTC_2793 7325131 81.82 µM -0.658812108396643 0.283405292124001 no 2423 0.255008215451987 3579 4176441 SGTC_325 2810-4341 181 µM -0.658853847641139 0.283393215731839 no 2424 0.254994812528933 3611 774970 SGTC_1617 st002906 78 µM -0.659942100763346 0.283078439170331 no 2425 0.254645492795599 3628 5150859 SGTC_167 3672-0051 66.205 µM -0.660086247974675 0.283036757264486 no 2426 0.254599241605782 3581 3237971 SGTC_1270 0831-1170 17.3 µM -0.660322825857937 0.28296835430005 no 2427 0.254523342574592 3603 6764716 SGTC_1702 st027038 51 µM -0.66157988890004 0.282605026468734 no 2428 0.254120249922496 3615 5521182 SGTC_2551 apiole 73.87 µM -0.662782759469523 0.282257571924024 no 2429 0.253734848479437 3498 10659 A possible DNA adduct former. SGTC_3182 9108849 49.47 µM -0.663517323903201 0.282045490851556 no 2430 0.253499644018687 3634 17133045 SGTC_137 0438-0332 85.389 µM -0.663836395963178 0.28195339330801 no 2431 0.253397514178393 3644 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2221 6807166 181.081 µM -0.66404378201398 0.281893540787471 no 2432 0.253331144833208 3568 674925 SGTC_2195 6536160 144.242 µM -0.664109010539644 0.281874716815481 no 2433 0.253310271767201 3511 3834386 SGTC_1138 3761-0006 1.03 µM -0.667087770505032 0.281015737477329 no 2434 0.252358035650253 3604 12061087 SGTC_2665 lovastatin 100 µM -0.667956084258512 0.2807655817944 no 2435 0.252080812770112 3622 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2817 7995342 71.43 µM -0.668606344421023 0.280578316514365 no 2436 0.251873312197519 3586 18879975 SGTC_3023 9089636 49.47 µM -0.670053537648143 0.280161763400496 no 2437 0.251411830964597 3708 17249241 SGTC_2945 9067681 61.76 µM -0.670176263715445 0.28012645230955 no 2438 0.251372716620634 3699 16456930 SGTC_964 1287-0107 19.4 µM -0.670351783715146 0.280075954947443 no 2439 0.251316781775693 3640 51516812 YPR165W RHO1 SGTC_571 k831-0106 44.2 µM -0.671279767679416 0.2798090459487 no 2440 0.251021160548404 3609 4783639 SGTC_485 niflumic acid 177 µM -0.671756755566109 0.279671901564231 no 2441 0.250869281545618 3637 4488 A COX2 inhibitor. SGTC_3275 9138069 49.47 µM -0.672049196752119 0.279587834502202 no 2442 0.250776188616401 3649 17617007 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.672641969429848 0.279417469822414 no 2443 0.250587547161387 3668 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2130 NSC 7 2.4545 µM -0.672943532343259 0.279330819074269 no 2444 0.250491607920437 3625 21448 SGTC_771 0250-0039 27.3 µM -0.673592000197524 0.279144533285016 no 2445 0.250285370269778 3620 3005115 SGTC_1503 4585-0012 61.3 µM -0.674490759476595 0.278886446017434 no 2446 0.249999679274407 3647 2922052 SGTC_1201 1889-3372 45.9 µM -0.674501435925356 0.278883380871635 no 2447 0.249996286563637 3568 5392199 SGTC_3194 9111903 49.47 µM -0.674814915669911 0.27879338998318 no 2448 0.249896681362368 3648 17087251 SGTC_2464 5717415 7.67 µM -0.676398032873725 0.278339139259722 no 2449 0.249393982930044 3575 5285744 SGTC_2046 4110841 106 µM -0.677067409412392 0.278147180704421 no 2450 0.249181592844806 3647 44119630 YMR134W ERG29 SGTC_817 1391-0715 46 µM -0.678313131494444 0.277790114276497 no 2451 0.248786587219195 3613 1353946 SGTC_1501 4491-0275 38.4 µM -0.679687516770756 0.277396428457604 no 2452 0.248351170937608 3633 5104718 SGTC_2685 mycophenolic acid 18.85 µM -0.681451972976641 0.276891408988438 no 2453 0.247792773126455 3618 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3337 9144342 33.5465 µM -0.681578042010136 0.276855342978201 no 2454 0.247752901707292 3642 17682949 SGTC_191 3914-0123 66.505 µM -0.684401594039592 0.27604818050737 no 2455 0.246860804859863 3583 3144412 SGTC_3253 9135987 49.47 µM -0.684788970231746 0.275937532349386 no 2456 0.246738548224126 3644 4182430 SGTC_1409 3909-8004 61.9 µM -0.685321619214861 0.27578542479277 no 2457 0.246570496179468 3665 2119279 SGTC_2319 6033012 152.6 µM -0.685728494929884 0.275669261834817 no 2458 0.246442167224037 3622 847246 SGTC_859 0439-0102 54.6 µM -0.687891841021908 0.275052031089744 no 2459 0.245760447453971 3672 610143 SGTC_901 1112-0062 60.1 µM -0.689971217714806 0.274459400228377 no 2460 0.245106143825801 3667 1908457 SGTC_539 4859-0462 2.54 µM -0.690426604993507 0.274329697153996 no 2461 0.244962975303712 3671 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2862 9027634 71.43 µM -0.69078687740187 0.274227106072827 no 2462 0.244849741689879 3595 5012562 SGTC_422 cantharidin 155 µM -0.693030759909002 0.27358856547778 no 2463 0.244145124010214 3633 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_882 0843-0131 351 µM -0.693055087866647 0.273581646516116 no 2464 0.244137490609653 3685 5425421 SGTC_1787 fluconazole 80 µM -0.693455255065819 0.273467849903749 no 2465 0.244011948334627 3586 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_941 3237-0776 460 µM -0.694116524828423 0.273279854228399 no 2466 0.243804568119546 3668 760008 SGTC_621 3584-0052 32.1 µM -0.69513248956076 0.27299114533951 no 2467 0.243486137773676 3675 2273927 SGTC_1424 4048-1941 275 µM -0.695505323354354 0.272885234298117 no 2468 0.24336933813233 3740 X1424 SGTC_2872 9044037 25.97 µM -0.696455947023497 0.272615282515176 no 2469 0.243071668222292 3663 6465195 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.696794308179905 0.272519228962996 no 2470 0.242965764329056 3695 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2571 chrysanthemic acid 100 µM -0.698149626013614 0.272134651528225 no 2471 0.242541812802525 3642 2743 An insecticide. SGTC_192 3455-0609 60.9 µM -0.698580394617131 0.272012475555923 no 2472 0.242407149759303 3719 3769639 SGTC_2036 5160441 105 µM -0.700452124697661 0.27148192643706 no 2473 0.241822496850784 3684 134534 YIL048W NEO1 SGTC_1552 6-methylflavone 10.6 µM -0.701999250950007 0.271043776995137 no 2474 0.241339815289992 3643 689013 SGTC_956 1185-0240 191 µM -0.702647110810813 0.27086040653916 no 2475 0.241137847760072 3690 1416193 SGTC_829 1635-0120 117 µM -0.702658044642384 0.270857312355441 no 2476 0.24113443997364 3690 285054 SGTC_2644 guaiazulene 100 µM -0.705001160263289 0.270194637300386 no 2477 0.240404757055272 3705 3515 A coloring agent. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.706677047946481 0.269721164131009 no 2478 0.239883598016659 3688 4330530 SGTC_1159 4092-0538 61.2 µM -0.708396283550725 0.269235876459643 no 2479 0.239349599856537 3723 717301 SGTC_3045 9092950 49.47 µM -0.708500879961183 0.269206366228567 no 2480 0.239317132959931 3689 44120432 SGTC_197 4544-0043 41.561 µM -0.709844911675216 0.268827313271538 no 2481 0.238900157467528 3689 896523 SGTC_918 glabranin 770.725 nM -0.711532413733079 0.268351772326463 no 2482 0.238377186023292 3721 124049 Also referred to as licorice root. SGTC_3110 9122132 49.47 µM -0.711639053395999 0.268321735307534 no 2483 0.238344158546225 3806 918317 SGTC_400 oxethazaine 37.5 µM -0.711705560039111 0.268303003346725 no 2484 0.238323561975964 3695 4621 A local anesthetic. SGTC_2159 5658611 73.75 µM -0.711975011436657 0.268227117614785 no 2485 0.238240125030694 3695 793844 SGTC_2423 st077119 87.2 µM -0.712918821926211 0.267961396982744 no 2486 0.23794799572342 3650 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_610 4215-0184 155 µM -0.714775602458309 0.267439025741036 no 2487 0.237373856540764 3729 5605015 SGTC_1591 genipin 88.4 µM -0.714956313103428 0.267388213545145 no 2488 0.237318019251998 3695 442424 A DNA cross-linking agent. SGTC_2757 clomiphene 4.22 µM -0.715435845823096 0.267253402208047 no 2489 0.237169884717887 3750 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_976 1348-1067 47.6 µM -0.715437730654163 0.267252872391977 no 2490 0.237169302566783 3740 5310671 YGL099W LSG1 SGTC_2662 daunorubicin 22.37 µM -0.715564466677172 0.267217248780579 no 2491 0.237130160533106 3599 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2940 9060638 45.86 µM -0.716101368951053 0.267066360121935 no 2492 0.236964379279426 3710 4027022 SGTC_1991 st073000 8.92 µM -0.716386033565389 0.266986376683272 no 2493 0.236876508208165 3754 4301969 YIL048W NEO1 SGTC_2697 mebhydrolin 72.4 µM -0.716730451135352 0.266889620376611 no 2494 0.236770216381353 3693 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_410 α-linolenic acid 100 µM -0.718989999442209 0.266255291156487 no 2495 0.23607354075275 3771 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1317 1273-0028 910 nM -0.720268131326133 0.265896815898267 no 2496 0.235679961180808 3698 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2143 5623677 140.463 µM -0.72176652791512 0.26547687504819 no 2497 0.235219015917267 3664 5375313 SGTC_2075 5212009 200 µM -0.722199820862765 0.265355503054299 no 2498 0.23508581672904 3611 780898 SGTC_134 0269-0018 6.916 µM -0.725260338781443 0.264499007874852 no 2499 0.234146166131132 3649 4378915 SGTC_2596 sinensetin 100 µM -0.728090167076875 0.263708325481328 no 2500 0.233279196313704 3745 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3020 9089140 49.47 µM -0.729204000081003 0.263397440357184 no 2501 0.232938442364903 3750 17217859 SGTC_1634 st006576 41 µM -0.729333407122052 0.263361333322891 no 2502 0.23289887091726 3693 3915356 SGTC_1973 st070275 50.2 µM -0.732410644159188 0.262503470673473 no 2503 0.231958981965776 3649 17118334 SGTC_120 rhodamine 6G 52.259 µM -0.733638415520887 0.26216159600877 no 2504 0.231584570690068 3763 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2499 avocadenofuran 51.48 µM -0.735490123377393 0.261646417215053 no 2505 0.231020526428748 3732 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2280 7785178 200 µM -0.735682632967826 0.261592887376982 no 2506 0.230961930584363 3742 2954328 SGTC_2237 6667747 47.222 µM -0.736223492791194 0.261442524235982 no 2507 0.230797348713013 3685 729940 YDL015C TSC13 SGTC_3184 9108758 49.47 µM -0.736518921083788 0.261360411671256 no 2508 0.230707478519882 3736 902885 SGTC_764 1951-2361 146 µM -0.736744782323585 0.261297643797489 no 2509 0.230638784025855 3714 5438930 SGTC_220 paclitaxel 373.376 µM -0.739463974317452 0.260542576177964 no 2510 0.229812653862395 3678 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_834 0312-0008 75.7 µM -0.740659813904579 0.260210870402889 no 2511 0.229449865573722 3736 6385573 YIL048W NEO1 SGTC_2923 7992654 58.14 µM -0.740824383004985 0.260165238746783 no 2512 0.229399964496839 3773 2985126 SGTC_2964 9083345 53.42 µM -0.740917697332966 0.260139366418784 no 2513 0.229371672182701 3726 17741579 SGTC_2676 harmalol 100 µM -0.742366451470573 0.259737855091906 no 2514 0.228932670083511 3726 5459187 A monoamine oxidase inhibitor SGTC_2728 chlorpromazine 9.18 µM -0.745730316895929 0.258806819997682 no 2515 0.227915170738833 3756 2726 A thorazine and dopamine antagonist. SGTC_1418 3966-3099 2.4 µM -0.747376014861855 0.258351961273627 no 2516 0.227418309658442 3734 740335 SGTC_328 k915-0120 63.5 µM -0.747931374015215 0.258198557652867 no 2517 0.227250776135979 3752 6624543 SGTC_2620 irigenin 100 µM -0.748074608498812 0.258159000487837 no 2518 0.227207578306013 3771 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_364 0083-0097 67.7 µM -0.748839608539091 0.257947783121389 no 2519 0.226976941703875 3816 5207356 SGTC_1203 3992-3522 103 µM -0.750801271670064 0.25740657571335 no 2520 0.226386131997908 3858 5322312 SGTC_2755 lomerizine 42.69 µM -0.751285535138337 0.257273062097886 no 2521 0.226240416295413 3762 3949 A calcium channel blocker. SGTC_2601 securinine 100 µM -0.751518641102579 0.257208806571911 no 2522 0.226170293210831 3728 442872 A GABA receptor antagonist. SGTC_3308 9128332 17.569 µM -0.751898116481153 0.257104222249461 no 2523 0.22605616546061 3739 17332805 YDL196W YDL196W SGTC_1699 st031318 29.054 µM -0.753269110666146 0.256726557334062 no 2524 0.225644108405415 3826 5340658 SGTC_1129 3453-1384 223 µM -0.754713044105213 0.256329112490294 no 2525 0.225210589077706 3893 1084452 SGTC_3044 9093193 49.47 µM -0.755217947812541 0.256190212701528 no 2526 0.225059110722515 3739 25236277 SGTC_339 3091-4833 71.4 µM -0.75603409554739 0.255965772219502 no 2527 0.22481437682229 3691 3240077 SGTC_3082 9117008 49.47 µM -0.756684557098996 0.255786968899802 no 2528 0.224619434460504 3827 41448529 SGTC_252 miconazole 1.30953 nM -0.758378926315347 0.255321515410659 no 2529 0.224112084992179 3726 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3164 9100705 49.47 µM -0.759254524235192 0.255081156983831 no 2530 0.223850157679716 3756 17174235 SGTC_2070 5230947 200 µM -0.759776570742192 0.254937907505022 no 2531 0.223694074946728 3819 2835538 SGTC_992 3909-8734 162 µM -0.761118646533106 0.254569835431431 no 2532 0.223293102006448 3795 4288319 SGTC_1590 st077108 57.8 µM -0.762520000702869 0.254185803216598 no 2533 0.222874855325711 3721 5489485 SGTC_1739 st037196 92.5 µM -0.763064295461174 0.254036724651989 no 2534 0.222712526110419 3780 612214 SGTC_1675 st018485 24.5 µM -0.763319388071709 0.253966872342762 no 2535 0.222636471074899 3843 3323024 SGTC_4 0960-0234 25.671 µM -0.763437963236371 0.253934406197784 no 2536 0.222601123314837 3753 6821112 SGTC_1757 st041620 31.8375 µM -0.763492608178612 0.253919445023716 no 2537 0.222584834502578 3845 5289815 SGTC_311 1315-0136 58 µM -0.763523228078611 0.253911061839772 no 2538 0.222575707480974 3817 6759207 SGTC_1605 st000082 49.1 µM -0.764229352006319 0.253717777975306 no 2539 0.222365288914223 3782 1114022 SGTC_2480 5767542 37.17 µM -0.765981023022899 0.253238635356337 no 2540 0.221843796922678 3778 2867358 SGTC_1891 st059073 26.2 µM -0.766371777199144 0.253131815516066 no 2541 0.221727560414025 3783 688754 SGTC_929 2805-0021 398 µM -0.766444127899227 0.253112039722295 no 2542 0.221706042280031 3851 3098024 SGTC_1296 1068-0102 11.9 µM -0.766732085731896 0.25303333955836 no 2543 0.221620411323654 3791 767053 SGTC_623 k072-0108 16.9 µM -0.766797577937383 0.253015442042827 no 2544 0.221600938332267 3782 5382803 SGTC_314 1671-0008 2.74 µM -0.768827891815576 0.252460934449182 no 2545 0.220997744327101 3722 3913060 SGTC_38 0929-0051 58.268 µM -0.768884304562026 0.25244553647537 no 2546 0.220980997869478 3805 1379719 SGTC_1505 k297-0037 20.6 µM -0.769401430667177 0.252304408920355 no 2547 0.220827519775173 3784 4089396 SGTC_1001 4048-4355 44.4 µM -0.770060278775846 0.252124664652375 no 2548 0.22063206838881 3778 21824233 SGTC_864 0469-0573 172 µM -0.771416736846895 0.251754814057769 no 2549 0.220229978875433 3763 689425 SGTC_3268 9137683 49.47 µM -0.771824223619475 0.25164376507684 no 2550 0.220109271304244 3803 1953228 SGTC_1709 st033179 39.1045 µM -0.77297289856638 0.251330865565515 no 2551 0.219769209964284 3758 573381 SGTC_1169 aniline yellow 25.8 µM -0.775294493124533 0.250699090778075 no 2552 0.219082831326621 3739 6051 A DNA damaging agent. SGTC_3352 9151559 45.5865 µM -0.77548340043973 0.250647720518537 no 2553 0.219027035227663 3789 17159339 SGTC_769 0302-0231 76 µM -0.775917156577319 0.250529788721762 no 2554 0.218898950947777 3767 571869 YER009W NTF2 SGTC_3343 9148379 18.9835 µM -0.776364480549656 0.250408198834817 no 2555 0.218766905352622 3843 1955036 SGTC_1734 st037168 69.4 µM -0.77708299229273 0.250212961215228 no 2556 0.2185549037941 3861 708907 SGTC_44 0929-0055 61.211 µM -0.777463607421466 0.250109571277927 no 2557 0.218442648770776 3760 1379590 SGTC_1778 st046819 58.9 µM -0.778272893541932 0.249889812897152 no 2558 0.21820407597795 3847 671715 SGTC_2702 st077768 96.8 µM -0.779174010309394 0.249645238922944 no 2559 0.217938608804372 3768 6484119 SGTC_1104 tacrolimus 29.8 µM -0.779343862983848 0.249599153101175 no 2560 0.217888591418542 3827 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2366 9070441 60.58 µM -0.782815362759568 0.248658228256992 no 2561 0.216867772360865 3804 6837235 SGTC_2922 7999257 32.47 µM -0.782917173203229 0.248630661818311 no 2562 0.216837876071874 3776 2988377 SGTC_1073 triclabendazole 3.09 µM -0.783013582443922 0.248604559322878 no 2563 0.216809568024321 3888 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1210 3013-0140 750 nM -0.783652728727872 0.248431549422437 no 2564 0.216621953510672 3843 905973 SGTC_1928 4'-methoxychalcone 40.3 µM -0.783660118221204 0.248429549542802 no 2565 0.216619784953729 3865 641818 SGTC_2807 7945238 51.95 µM -0.783717961447214 0.248413895249086 no 2566 0.216602810430911 3849 17148797 SGTC_968 1309-0633 340 µM -0.784384515957452 0.248233541452942 no 2567 0.216407260605326 3815 3761976 SGTC_421 streptovitacin 30 mM -0.785109839563552 0.248037365493837 no 2568 0.216194585579481 3912 91467 include heat shock SGTC_861 0443-0273 110 µM -0.788504321372593 0.247120371280321 no 2569 0.215200885939689 3847 6149169 SGTC_2716 st080858 38.6235 µM -0.789387822862156 0.246881997619166 no 2570 0.214942685422904 3807 5296050 SGTC_1426 4048-4480 71.7 µM -0.791182063558789 0.246398280404842 no 2571 0.214418878330697 3791 14224343 SGTC_3085 9117376 49.47 µM -0.79152198576325 0.246306696551857 no 2572 0.214319725814478 3920 16480349 SGTC_2507 purpurin 79.67 µM -0.792262777373357 0.246107171325015 no 2573 0.214103735396801 3829 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1387 3342-1166 1.8 µM -0.793354790771761 0.2458132059869 no 2574 0.21378557139139 3825 3418228 SGTC_3171 9103192 49.47 µM -0.793850395935364 0.24567985340577 no 2575 0.213641265038048 3843 13018434 SGTC_1640 st009078 66.4 µM -0.794109423495123 0.245610172269036 no 2576 0.213565866047903 3794 690618 SGTC_244 nsc-207895 1.295 µM -0.794974587243534 0.245377511081715 no 2577 0.213314142425368 3676 42640 SGTC_1241 0364-0022 50.8 µM -0.79504499995243 0.245358580799741 no 2578 0.213293663118572 3853 4563895 SGTC_2035 5154463 94.595 µM -0.796516689053467 0.24496310054994 no 2579 0.212865889586057 3827 2769623 SGTC_1569 carminic acid 40.6 µM -0.796856213407309 0.244871910445528 no 2580 0.212767271715011 3880 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_533 1222-0222 6.71 µM -0.797156852809765 0.244791179389297 no 2581 0.212679970593743 3915 3982874 SGTC_567 1080-0542 68.4 µM -0.798481478178522 0.244435646859424 no 2582 0.212295568667667 3725 5950415 SGTC_1848 st056003 16.4 µM -0.798825141618623 0.244343452269935 no 2583 0.212195905047541 3865 146492 SGTC_1967 st070177 51.4 µM -0.801926827053587 0.243512211654169 no 2584 0.211297643397153 3873 5729214 SGTC_19 0279-0214 38.434 µM -0.803337077582331 0.243134775305246 no 2585 0.2108899664521 3887 3566274 YBR002C RER2 SGTC_2818 7996756 12.99 µM -0.806184502568401 0.242373661865786 no 2586 0.21006823656683 3832 2241621 SGTC_2316 5844804 197.44 µM -0.810306388148526 0.241274177454147 no 2587 0.208882052373216 3907 776813 SGTC_2360 9040895 200 µM -0.810419152138675 0.241244136578082 no 2588 0.208849657032453 3879 4914414 SGTC_1514 1189-1591 158 µM -0.811543651475661 0.240944675718154 no 2589 0.208526767837879 3875 767698 YMR146C TIF34 SGTC_2610 ononetin 44.17 µM -0.811909887067706 0.240847188667914 no 2590 0.208421670377752 3863 259632 SGTC_845 0330-0138 4.51 µM -0.816094836050008 0.239734735926458 no 2591 0.207222948590826 3785 9039800 SGTC_588 3970-1144 52.9 µM -0.81620448340602 0.239705626955645 no 2592 0.207191596508252 3780 1888707 SGTC_1065 prochlorperazine maleate 2.48 µM -0.817868652908748 0.239264063288059 no 2593 0.206716095723482 3898 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1131 3454-3128 32.3 µM -0.822384906293071 0.238067982425121 no 2594 0.205428933492725 3940 710982 SGTC_1272 0839-0021 27 µM -0.826545213092804 0.236969076348246 no 2595 0.204247440673444 3906 5027250 SGTC_2444 5485484 36.41 µM -0.829197057940487 0.236270073989908 no 2596 0.203496454747026 3954 6790631 SGTC_881 0833-0569 170 µM -0.829270329506287 0.236250776399605 no 2597 0.203475728107106 3878 5418700 SGTC_2305 7443522 69.23 µM -0.829815935357557 0.236107107053605 no 2598 0.203321429861454 3805 5415886 SGTC_1628 st004252 77.7 µM -0.831368447007882 0.235698561966768 no 2599 0.202882759143058 3900 692968 SGTC_3331 9141060 1.957 µM -0.832557882223418 0.23538582477585 no 2600 0.202547060467166 3855 4906567 YPR165W RHO1 SGTC_916 4466-0038 42 nM -0.832676857026121 0.235354555437307 no 2601 0.202513500048616 3963 5722064 YGL116W CDC20 SGTC_2504 purpurogallin 52.29 µM -0.836057702923134 0.234466949675232 no 2602 0.201561220947084 3805 5281571 An antioxidant. SGTC_2429 5902844 64.44 µM -0.837469162730773 0.234096934374042 no 2603 0.201164451770264 3933 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2984 9022109 38.96 µM -0.839627521536038 0.23353174476581 no 2604 0.200558631627663 3902 6459207 SGTC_2056 5235370 200 µM -0.839822539944216 0.233480714390945 no 2605 0.200503946796698 3867 5511916 SGTC_2340 7987427 183.45 µM -0.839859620447252 0.233471012253078 no 2606 0.200493550119513 3905 2239331 SGTC_3090 9117696 49.47 µM -0.839906802922717 0.233458667250844 no 2607 0.200480321506935 3842 7923821 SGTC_394 menadione 8.33 µM -0.839956393777892 0.233445692501279 no 2608 0.200466418218822 3872 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1742 st038235 28.8875 µM -0.840093969192314 0.233409699923838 no 2609 0.200427850618694 3937 564103 YBR002C RER2 SGTC_745 0469-0705 296 µM -0.840163291820788 0.233391564855185 no 2610 0.200408418548753 3962 3486736 SGTC_1085 doxorubicin 7.67 µM -0.841915065279227 0.232933553679793 no 2611 0.199917748483021 3896 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2295 7971645 200 µM -0.843169094363427 0.232605987473512 no 2612 0.199566940230979 3953 2978226 YKL099C UTP11 SGTC_448 monastrol 171 µM -0.843203987271153 0.232596876725108 no 2613 0.199557184418228 3805 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3130 9127414 49.47 µM -0.844489600473077 0.232261333719753 no 2614 0.19919793610681 3896 1494646 SGTC_1851 st056236 18.9 µM -0.847493865135717 0.231478276500702 no 2615 0.198359952560089 3857 5393171 SGTC_2037 5169046 200 µM -0.848869884544808 0.231120111110789 no 2616 0.197976849008587 3966 5718022 SGTC_2591 skatole 100 µM -0.850794784062654 0.230619596516038 no 2617 0.197441679801119 3961 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1048 3161-0300 24.5 µM -0.851361742899518 0.230472290772708 no 2618 0.197284218289018 3894 2165101 SGTC_3327 9140648 26.9345 µM -0.85174695188039 0.230372236809173 no 2619 0.197177277526878 3929 8029710 SGTC_2034 5197015 53.07 µM -0.852698364840629 0.230125221438602 no 2620 0.196913298954941 3896 780676 SGTC_1725 st036284 20.55 µM -0.853584154678223 0.229895377064465 no 2621 0.196667720572703 4012 707914 SGTC_2068 5226020 147 µM -0.85376839068226 0.229847587732712 no 2622 0.196616665881048 3947 1810509 SGTC_234 nsc-17383 10.7 µM -0.855402512296475 0.229423953307711 no 2623 0.196164176638359 3890 408974 SGTC_1130 3454-2858 15.9 µM -0.855744380281259 0.229335381844718 no 2624 0.196069593127445 3962 715628 YIL048W NEO1 SGTC_2705 st078069 42.8 µM -0.856132722877447 0.229234792956653 no 2625 0.195962185199862 3951 1530061 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.856338088307764 0.229181608999459 no 2626 0.19590539959202 3900 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2948 9070189 9.45 µM -0.860595510361569 0.228080614579342 no 2627 0.194730429761896 3834 6473636 YDL196W YDL196W SGTC_1525 8-methoxypsoralen 92.5 µM -0.861849870690591 0.227756797804096 no 2628 0.19438506877385 3962 4114 Related to psoralen; DNA damaging agent. SGTC_1024 4507-0395 26 µM -0.862229867630016 0.227658751577613 no 2629 0.194280518473801 4004 4201836 SGTC_2532 xanthone 78.9 µM -0.862481585652623 0.227593816765709 no 2630 0.194211280998295 3913 7020 An insecticide. SGTC_3293 9120939 62.045 µM -0.862898228166351 0.227486359883226 no 2631 0.194096712475071 3899 934087 SGTC_33 0986-0033 35.816 µM -0.863403915766873 0.227355975647835 no 2632 0.19395771362421 3828 2848082 SGTC_384 k007-0144 5.16 µM -0.86435173843322 0.227111706728231 no 2633 0.193697348119501 3901 6824886 SGTC_511 blebbistatin 171 µM -0.864439190466144 0.227089176411155 no 2634 0.193673335916605 3991 3476986 A myosin inhibitor. SGTC_412 gemfibrozil 100 µM -0.8660924201829 0.226663491043276 no 2635 0.193219740776178 3872 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1125 tnp00248 1.32998 µM -0.866328602720468 0.226602713866422 no 2636 0.193154992562548 4026 24207736 SGTC_217 ketoconazole 989 nM -0.867012331334435 0.226426820913609 no 2637 0.192967626606546 3811 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1264 0783-0040 158 µM -0.869224972054529 0.225858135687482 no 2638 0.192362045564638 3834 2855798 SGTC_3333 9141820 12.094 µM -0.871379726416394 0.22530510535178 no 2639 0.191773425843056 3925 1939433 SGTC_2892 9047358 58.44 µM -0.872106073666896 0.225118857032183 no 2640 0.191575256521113 3930 6466771 SGTC_632 0781-2353 4.65 µM -0.875166072652557 0.224335177531739 no 2641 0.190741775240036 4000 6811515 YHR007C ERG11 SGTC_433 pimozide 108 µM -0.876127144495836 0.224089362666399 no 2642 0.190480458788386 3852 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_232 clozapine 119 µM -0.876849314332143 0.223904752863386 no 2643 0.190284244769778 3896 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1939 st074455 53.6 µM -0.877273812579197 0.223796277822697 no 2644 0.190168966280324 3946 1644229 SGTC_2704 st078022 71.1 µM -0.879400657562158 0.223253240060435 no 2645 0.18959203785856 3985 54697681 SGTC_3264 9137442 49.47 µM -0.87967563242614 0.223183086757812 no 2646 0.189517526805201 3901 17015726 SGTC_2285 7945142 200 µM -0.879808984019771 0.223149069786636 no 2647 0.189481398472261 3996 2970608 SGTC_3178 9107506 49.47 µM -0.879944375162643 0.22311453556218 no 2648 0.189444721909846 3985 8897194 SGTC_2033 5192550 145 µM -0.881327254835333 0.222761978705204 no 2649 0.18907035923256 3921 182073 SGTC_2085 5307070 144.047 µM -0.881350010806824 0.222756179863448 no 2650 0.189064202721886 3896 2840351 SGTC_117 lucigenin 22.078 µM -0.884514416597329 0.221950641169353 no 2651 0.188209291780949 3992 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_336 4111-0029 111 µM -0.885600728296824 0.221674491066814 no 2652 0.187916359494426 3945 3131175 SGTC_1797 st048695 56.8 µM -0.886220538373615 0.221517017833558 no 2653 0.187749349151936 3935 592262 YIL048W NEO1 SGTC_2526 patulin 37.61 µM -0.886658264147337 0.221405844734159 no 2654 0.187631457418983 4008 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2369 9071472 200 µM -0.887059709424079 0.221303914165905 no 2655 0.187523377249562 4036 17296037 SGTC_2988 9073640 71.4286 µM -0.888928226517155 0.220829834184506 no 2656 0.187020827223485 4015 9102229 SGTC_428 3448-4153 16.5 µM -0.890414307802959 0.220453201294664 no 2657 0.18662173126291 3929 3834874 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.892361751866216 0.219960198252951 no 2658 0.186099532556293 3974 616764 SGTC_2287 7945887 168.79 µM -0.894391515158304 0.219447029728279 no 2659 0.185556225311728 3981 1245853 SGTC_2302 7771753 200 µM -0.90114803290813 0.217743798221254 no 2660 0.183754808548933 3985 2203047 SGTC_2846 9008642 19.48 µM -0.903265223462794 0.217211655043432 no 2661 0.183192574449152 4057 2992898 SGTC_1156 4092-0367 4.88 µM -0.904551476933254 0.216888730091019 no 2662 0.182851525747673 3978 1357585 SGTC_1824 st053723 68.6 µM -0.905880623493778 0.216555328212566 no 2663 0.182499520622321 4015 675225 SGTC_2870 9038528 12.99 µM -0.9070912836197 0.216251905561898 no 2664 0.182179263521795 4044 6463316 SGTC_2447 5741742 33.78 µM -0.907885153979661 0.216053074866134 no 2665 0.181969451037091 4038 1776504 SGTC_352 k048-0007 5.11 µM -0.908677717688015 0.215854677103776 no 2666 0.181760134681534 3978 6811911 SGTC_63 0099-0242 26.702 µM -0.909096810942231 0.21574981066964 no 2667 0.181649512912677 4031 3898502 YLR359W ADE13 SGTC_2354 9060492 162 µM -0.909624766976477 0.215617746395565 no 2668 0.181510216245596 4058 6471895 SGTC_1251 0490-5699 265 µM -0.91201629516105 0.215020110785057 no 2669 0.180880069794366 4044 3883818 SGTC_3227 9130768 49.47 µM -0.912237280512989 0.214964935807875 no 2670 0.180821911398793 4008 17720899 SGTC_2517 totarol 10 µM -0.912771213501313 0.214831658917385 no 2671 0.180681440575269 4007 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2558 carylophyllene oxide 100 µM -0.915449261311534 0.214163906587698 no 2672 0.179977913731239 4099 6708694 An oxygenated terpenoid and antifungal agent. SGTC_369 0957-0393 4.5 µM -0.916429631240679 0.213919760560064 no 2673 0.179720799901302 4022 6997992 SGTC_2885 9057732 51.95 µM -0.916953965200639 0.213789249800777 no 2674 0.179583381767675 4059 6471414 SGTC_69 0096-0274 206.684 µM -0.917121727932774 0.213747502159094 no 2675 0.179539428237958 4149 6741392 SGTC_177 1327-0068 8.361 µM -0.919328864465478 0.213198700053263 no 2676 0.178961792270892 3985 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_577 r071-0003 38.6 µM -0.921398795839662 0.212684761371064 no 2677 0.178421128612107 4029 4568517 YMR134W ERG29 SGTC_1323 1348-1351 11.2 µM -0.921510976772112 0.212656928895992 no 2678 0.178391856509029 3945 6989654 SGTC_970 1315-0089 19.5 µM -0.921683563537669 0.212614113679355 no 2679 0.178346828226131 3934 6811083 YLR033W RSC58 SGTC_1109 tnp00067 928.257 nM -0.925811470868943 0.211591566064847 no 2680 0.177271982431983 3994 676295 SGTC_3041 9091929 49.47 µM -0.926452144224442 0.211433119684161 no 2681 0.177105528074415 4004 25236887 SGTC_308 4092-1169 104 µM -0.926771272522568 0.211354221273895 no 2682 0.177022651698757 3935 2268590 YDL196W YDL196W SGTC_2803 7707263 71.43 µM -0.927720418671943 0.211119664859234 no 2683 0.176776306986908 3978 2199229 SGTC_2381 9035592 200 µM -0.93230867461107 0.209987951729872 no 2684 0.175588512990738 4009 4749657 SGTC_1998 st075797 76.8 µM -0.933236090207707 0.209759634535436 no 2685 0.175349042285543 3947 24208315 SGTC_917 harmaline 728.087 nM -0.933300269073757 0.209743839966821 no 2686 0.175332478136122 3999 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2566 crystal violet carbinol 226 nM -0.933921649059439 0.209590953066624 no 2687 0.175172155294682 4071 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_3086 9117350 49.47 µM -0.936229347022486 0.209023731554054 no 2688 0.174577558155492 3963 2679265 SGTC_635 k038-0028 24.7 µM -0.937733961028284 0.208654391761221 no 2689 0.174190573200987 4012 4035102 SGTC_2186 6124449 200 µM -0.937914003549013 0.208610222245693 no 2690 0.174144303025063 4012 3834182 YLR033W RSC58 SGTC_131 0141-0277 33.849 µM -0.941290875500091 0.207782801876193 no 2691 0.173277908704312 3999 1547771 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.945026003421213 0.206869861144949 no 2692 0.172322800317673 4069 6708784 An antioxidant flavonoid SGTC_454 lyso-paf C-16 6.67 µM -0.945933894826665 0.206648313354884 no 2693 0.172091152064743 4012 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1954 st077032 68.9 µM -0.94646235818464 0.206519420045108 no 2694 0.171956406339043 4005 698907 SGTC_607 4491-0986 66.8 µM -0.94656724783759 0.206493842906507 no 2695 0.171929669958534 4045 698981 YDR232W HEM1 SGTC_1923 st058458 19.1 µM -0.948072864087462 0.206126908143562 no 2696 0.171546180790794 4069 3534982 SGTC_3332 9141069 11.198 µM -0.948562050059562 0.206007771557348 no 2697 0.171421700027246 3963 17332883 SGTC_1039 k821-0043 94 µM -0.949097812655078 0.205877338544743 no 2698 0.171285433395981 4055 15992768 SGTC_637 1181-0519 7.26 µM -0.951529223177453 0.205286020325612 no 2699 0.170667895533999 4028 6252091 YGR060W ERG25 SGTC_1934 st074720 32.6 µM -0.954788361946092 0.204494983480449 no 2700 0.169842366988471 3987 17250992 SGTC_1903 st060211 78.3 µM -0.955002602503512 0.204443048034927 no 2701 0.169788190432976 4081 688960 SGTC_1479 0549-0158 134 µM -0.955881554142448 0.204230057847137 no 2702 0.169566039604357 4060 5440202 SGTC_3191 9110352 49.47 µM -0.955934748664886 0.204217171833411 no 2703 0.169552600929958 3968 17122424 SGTC_3036 9090181 49.47 µM -0.957572054075772 0.203820782510196 no 2704 0.169139298314708 4058 25236586 SGTC_1154 4088-0362 150 µM -0.95905562068121 0.203462009471911 no 2705 0.168765362901676 4036 6618304 SGTC_3088 9117578 49.47 µM -0.960366025004906 0.203145426073645 no 2706 0.168435515528474 4080 678341 SGTC_2686 alizarin 95.37 µM -0.96160796306079 0.202845655179555 no 2707 0.168123284981579 4046 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_457 grayanotoxin iii 135 µM -0.968704379487822 0.20113784356136 no 2708 0.166346353422287 3910 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1202 1988-0068 29.6 µM -0.968992276803492 0.20106874117501 no 2709 0.166274521297325 4025 2850480 SGTC_481 bay k-8644 50 µM -0.969889924143088 0.200853375324569 no 2710 0.16605068147555 4010 2303 A calcium channel antagonist. SGTC_3287 9117173 37.0625 µM -0.970554223543994 0.200694084072932 no 2711 0.165885155359668 4028 2789709 SGTC_1280 0880-0253 10.1 µM -0.97096482828054 0.200595663778751 no 2712 0.165782896700456 4049 6836607 SGTC_3177 9107506 49.47 µM -0.971612862070901 0.200440391675196 no 2713 0.165621590682095 4010 8897194 SGTC_2290 7904846 200 µM -0.971652303683139 0.200430943600876 no 2714 0.165611776309174 4103 2962154 SGTC_1863 st057641 20.1 µM -0.973894574607333 0.199894256906048 no 2715 0.165054443920323 4069 3921635 SGTC_1116 jasmonic acid  1.58368 µM -0.974948365398996 0.199642331282755 no 2716 0.164792936650557 4123 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1113 artemisinin 1.17947 µM -0.976335220444245 0.199311072617482 no 2717 0.16444918587189 4107 2240 An anti-malaria and mitochondrial poison. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.976641381892675 0.199237988738315 no 2718 0.164373362291022 4101 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_3306 9127676 59.7925 µM -0.979319837502134 0.198599302407813 no 2719 0.163710985834613 4062 41905287 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.979868773838244 0.198468559413521 no 2720 0.163575449272387 4116 61125 An anti-inflammatory. SGTC_185 k048-0037 25.491 µM -0.981002747004859 0.198198639669275 no 2721 0.163295693453867 4113 6827589 SGTC_2476 5806916 10.51 µM -0.982267588039911 0.197897831020577 no 2722 0.162984018948073 3931 2870194 SGTC_1905 st060207 84.5 µM -0.984493814124905 0.197369052969063 no 2723 0.162436385731179 4024 1948547 SGTC_2278 7948257 134.34 µM -0.986283448461234 0.196944595331927 no 2724 0.161997019773597 4074 1247028 SGTC_1423 4048-0112 5.59 µM -0.986879980168795 0.196803235439383 no 2725 0.161850739842386 4105 X1423 SGTC_1983 st071813 46.9 µM -0.989309402779545 0.196228171013386 no 2726 0.161255892502698 4126 11838595 SGTC_2098 5376439 882.5 nM -0.989701624592904 0.196135424481398 no 2727 0.161159990351242 4122 2844116 SGTC_2585 alliin 100 µM -0.991312258988978 0.195754845449275 no 2728 0.160766564396558 4138 87310 A garlic compound which reacts with lipids. SGTC_2749 bexarotene 57.39 µM -0.991471756260627 0.195717182024704 no 2729 0.160727638520381 4123 82146 An retinoic acid receptor inhibitor. SGTC_913 3487-1245 167 µM -0.992801791445649 0.195403281003321 no 2730 0.160403278376911 4014 4016153 SGTC_1160 4092-0570 10.5 µM -0.994415352020828 0.195022876097105 no 2731 0.160010348556459 4074 4994975 SGTC_2624 nerol 100 µM -0.995779015292166 0.194701737010932 no 2732 0.159678764214334 3989 637566 A natural product oil. SGTC_780 0109-0199 192 µM -0.995901018151581 0.194673021348497 no 2733 0.15964912028739 4193 610414 SGTC_1752 st044819 83.042 µM -0.998673731694529 0.194021106103877 no 2734 0.15897638484593 4090 441209 YML126C ERG13 SGTC_712 r015-0009 80.6 µM -0.998759778908621 0.194000896146506 no 2735 0.15895553722089 4120 6813872 YLR060W FRS1 SGTC_3148 9097893 49.47 µM -0.998819899662913 0.193986776312503 no 2736 0.158940972153657 4084 17174100 SGTC_1673 st016611 27.3 µM -0.999347902705159 0.193862797528774 no 2737 0.158813093833055 4119 5226799 SGTC_2299 7976368 114.88 µM -1.00186757809964 0.193271825649055 no 2738 0.158203776683895 4121 2979718 SGTC_3277 9138724 49.47 µM -1.00360002443709 0.192866131306058 no 2739 0.157785721398326 4032 15943418 SGTC_909 3448-9333 149 µM -1.00376715697997 0.19282702069738 no 2740 0.157745429183925 4011 3344074 SGTC_128 0906-2981 13.371 µM -1.00463781887942 0.192623355883961 no 2741 0.157535639845885 4079 6740226 SGTC_3146 9095609 49.47 µM -1.00741449626465 0.191974715543542 no 2742 0.156867813978136 4147 17173999 SGTC_808 0711-0032 135 µM -1.00752257111948 0.191949495984935 no 2743 0.156841858332844 4015 4252555 SGTC_3221 9128209 49.47 µM -1.00759299073322 0.191933064469472 no 2744 0.156824947626136 4129 16460723 SGTC_1754 st042065 16.137 µM -1.00919712815652 0.19155899275999 no 2745 0.156440051832881 3916 1126236 YIL048W NEO1 SGTC_3061 glucosamine 200 µM -1.01123567258722 0.191084265806243 no 2746 0.155951823007527 4004 91431 and experimental redox chemotherapeutic SGTC_1389 3405-0187 19 µM -1.01153667921483 0.191014229930871 no 2747 0.15587981748977 4063 799890 SGTC_698 k064-0052 127 µM -1.01251477470768 0.190786763012214 no 2748 0.155645993012215 4185 5088751 SGTC_2933 9026794 32.47 µM -1.01562986567933 0.190063422533235 no 2749 0.154902838650252 4061 17586027 SGTC_36 0335-0881 14.2 µM -1.01600872216157 0.189975565171883 no 2750 0.154812616541369 4011 23828853 SGTC_451 chloral hydrate 100 µM -1.02459692600518 0.187990650852824 no 2751 0.152776707786042 4140 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2380 9035439 200 µM -1.02533065816913 0.187821665637771 no 2752 0.152603597281846 4221 6462575 SGTC_246 cycloheximide 667 µM -1.02845232848289 0.187103765578036 no 2753 0.15186855214065 4002 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_549 1661-1316 519 µM -1.02985707945879 0.186781265168902 no 2754 0.151538550675597 4151 2857282 SGTC_1663 st014140 55.4 µM -1.03135091106115 0.18643869150781 no 2755 0.151188145959401 4196 4207120 SGTC_2415 st077333 57.7 µM -1.03219732673592 0.186244759662008 no 2756 0.150989843560499 4182 2766255 SGTC_3029 9088683 49.47 µM -1.03336578684654 0.185977246059814 no 2757 0.150716375560085 4167 25236615 SGTC_2788 5282734 71.43 µM -1.03715417762356 0.185111550863767 no 2758 0.149832004695159 4227 743706 SGTC_2015 5119600 184 µM -1.03788654230459 0.184944485449513 no 2759 0.149661439805667 4165 2828786 SGTC_2646 retinol 96.75 µM -1.04498036460699 0.183331110883437 no 2760 0.14801602233728 4134 445354 A vitamin A analog and teratogen. SGTC_536 3852-0578 10.6 µM -1.04548730797763 0.183216151809487 no 2761 0.147898901771158 4197 2869208 SGTC_2093 5331342 194.4 µM -1.04616208887804 0.183063202142318 no 2762 0.147743101501404 4212 33839 SGTC_2884 9058502 51.95 µM -1.047703716709 0.182714067027782 no 2763 0.147387567319922 4184 6471554 SGTC_3226 9131256 49.47 µM -1.04778752918974 0.182695097793325 no 2764 0.147368254715668 4082 17178073 SGTC_2079 5212404 121 µM -1.04959294011894 0.182286778656026 no 2765 0.146952652170755 4116 758462 SGTC_102 gallobenzophenone 83.616 µM -1.05012302038814 0.182167001911135 no 2766 0.146830778012211 4149 70837 SGTC_1540 guanosine 70.6 µM -1.05099140600623 0.181970888148359 no 2767 0.146631268459703 4013 6802 Guanosine is a purine nucleoside SGTC_2570 licareol 100 µM -1.05671610607024 0.180681344177148 no 2768 0.145320586075222 4152 443158 SGTC_1796 st049173 110.4 µM -1.0578821331853 0.180419389415618 no 2769 0.145054590844049 4103 94134 SGTC_974 1326-0144 138 µM -1.05882962747204 0.180206704882984 no 2770 0.144838689018355 4170 5411856 SGTC_2379 9035213 200 µM -1.06750415936851 0.178266849560119 no 2771 0.14287211821288 4166 646551 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.06778514938802 0.178204233577441 no 2772 0.142808719214417 4131 803109 SGTC_748 act1.228 77.9 µM -1.06926775223153 0.177874079055042 no 2773 0.14247451855413 4105 4421505 YNR035C ARC35 SGTC_3218 9131285 49.47 µM -1.0704516299075 0.177610723577425 no 2774 0.142208035117061 4135 17156417 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.07244326440549 0.177168236793673 no 2775 0.141760492121926 4125 2333 A French combination drug. SGTC_251 melphalan 456.522 µM -1.07270496716636 0.177110145391251 no 2776 0.141701755512081 4205 460612 A DNA alkylator. SGTC_551 k048-0028 34.9 µM -1.07351165203297 0.176931157446904 no 2777 0.141520806762266 4160 6836383 SGTC_1253 0550-0034 176 µM -1.07483533592887 0.17663770508139 no 2778 0.141224228514287 4194 5969915 SGTC_387 norethindrone acetate 66.7 µM -1.07621304138004 0.176332603539088 no 2779 0.140915994273253 4185 541197 SGTC_776 4476-4378 112 µM -1.07961783410801 0.175580022098784 no 2780 0.140156198222175 4225 2892008 SGTC_810 3825-7150 143 µM -1.08149557738083 0.175165845569251 no 2781 0.139738363462645 4260 22330411 YGL099W LSG1 SGTC_1386 3228-0095 33.8 µM -1.08277679681834 0.174883601113718 no 2782 0.139453753496326 4194 870181 SGTC_531 3788-1495 174 µM -1.08372694682477 0.174674475630412 no 2783 0.139242942066149 4147 2896655 SGTC_1946 st076057 65.1 µM -1.08390280502858 0.17463578712829 no 2784 0.139203947896665 4112 953009 SGTC_2796 7949634 45.45 µM -1.08448781353097 0.174507125424112 no 2785 0.139074283685714 4151 2971588 SGTC_469 w7 172 µM -1.0866686767688 0.174028015977364 no 2786 0.138591630913481 4256 45115570 A P450 inhibitor. SGTC_2616 abietic acid 100 µM -1.0871153038561 0.173930000637423 no 2787 0.138492927615623 4222 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2950 9072895 21.46 µM -1.09071403248328 0.173141516607563 no 2788 0.13769936702742 4154 17332245 SGTC_1646 st011709 75.6 µM -1.09114659386033 0.173046895603229 no 2789 0.137604191654288 4134 5757843 SGTC_2074 5212007 75.395 µM -1.09352829812968 0.172526497858312 no 2790 0.137080955680792 4086 758611 SGTC_1174 0739-0097 51.1 µM -1.09421672696223 0.172376263618226 no 2791 0.136929968508621 4214 728447 SGTC_2063 5246145 200 µM -1.09501673638949 0.172201784272825 no 2792 0.136754652152859 4218 711240 SGTC_175 3793-3120 23.7 µM -1.10037719964802 0.171035594375641 no 2793 0.13558390422923 4204 5322297 SGTC_1305 1181-0477 144 µM -1.10236025872656 0.170605455194119 no 2794 0.135152540832177 4257 6252086 SGTC_2168 5727979 200 µM -1.10237998914407 0.170601179013125 no 2795 0.135148253721507 4097 695210 SGTC_478 N-arachidonylglycine 10 µM -1.10357170292163 0.17034302567133 no 2796 0.134889485873387 4173 5283389 SGTC_2145 5634607 200 µM -1.10461269560798 0.170117726943069 no 2797 0.134663723787506 4161 308662 SGTC_569 4130-2812 160 µM -1.10474269519943 0.170089604964816 no 2798 0.134635548750613 4025 743552 SGTC_798 1287-0182 476 µM -1.10494730776571 0.170045348475481 no 2799 0.134591210910153 4238 1649755 SGTC_2913 7966556 36.57 µM -1.10849643901498 0.169278866891328 no 2800 0.133823738089285 4079 2976516 SGTC_1267 0828-0272 9.49 µM -1.10855664291008 0.169265884227277 no 2801 0.133810745450189 4289 745334 SGTC_1885 st057546 99.9 µM -1.11074018588295 0.168795446319492 no 2802 0.133340099664168 4234 702008 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.11108474420021 0.168721289063528 no 2803 0.133265936946066 4211 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_3046 9092212 49.47 µM -1.11284856629225 0.168342000021303 no 2804 0.132886736497659 4261 25236637 SGTC_1993 st073995 70.8 µM -1.11450710882249 0.16798585076913 no 2805 0.132530848227665 4190 3098394 SGTC_2339 9000433 200 µM -1.11567985214188 0.167734313138004 no 2806 0.132279598909325 4235 2988954 SGTC_1618 st003135 44.5 µM -1.11735063581702 0.167376371707452 no 2807 0.131922216489532 4181 1270615 SGTC_809 3998-0021 90 µM -1.12083382958441 0.166631731439359 no 2808 0.131179300638319 4164 715485 SGTC_759 3486-0358 89.3 µM -1.12116684756314 0.166560650706184 no 2809 0.131108424270057 4206 875103 SGTC_1281 0884-0031 11.8 µM -1.12117236581252 0.166559473033102 no 2810 0.131107250041374 4232 1548255 SGTC_1832 st054113 55 µM -1.12194896763765 0.166393788737485 no 2811 0.130942069333117 4224 1251267 SGTC_971 1315-0384 26.7 µM -1.12375461628434 0.166008973720655 no 2812 0.130558569726082 4253 6769120 SGTC_1318 1280-3875 124 µM -1.12416169808379 0.165922297037668 no 2813 0.130472217494669 4213 373245 SGTC_259 usnic acid 108.925 µM -1.1247728301493 0.165792228482578 no 2814 0.130342655273359 4298 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_634 1611-4317 11.2 µM -1.12636797331028 0.165453041375071 no 2815 0.130004898545001 4259 2843522 SGTC_2759 disulfiram 3.38 µM -1.12666571530094 0.165389780040072 no 2816 0.129941921601963 4124 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_135 0933-0004 26.348 µM -1.12755178718399 0.165201608664783 no 2817 0.129754628929548 4195 21230617 YGL099W LSG1 SGTC_1454 4239-0054 42.6 µM -1.13052680770914 0.164570830107052 no 2818 0.129127154501735 4323 1340767 SGTC_2780 5215298 71.43 µM -1.13059154028346 0.164557122559228 no 2819 0.129113524900541 4240 2834131 SGTC_363 0455-0021 3.06 µM -1.13107237963042 0.164455324831035 no 2820 0.129012314226607 4186 4597466 SGTC_508 roscovitine 141 µM -1.13137156366083 0.164392005664172 no 2821 0.128949367499723 4285 160355 A CDKinase inhibitor. SGTC_278 4092-0821 23.9 µM -1.13267810533521 0.164115675042131 no 2822 0.128674727717544 4221 877900 SGTC_3239 9133757 49.47 µM -1.13485553213825 0.163655824031586 no 2823 0.128217927097104 4252 17036923 SGTC_2308 7584454 197.62 µM -1.13504799566537 0.163615217914963 no 2824 0.128177604566679 4289 893577 SGTC_1883 5-benzylidenerhodanine 20 µM -1.13637131229312 0.163336200595261 no 2825 0.127900598407862 4210 1273210 SGTC_557 1315-0110 16.2 µM -1.13790928126136 0.163012313097377 no 2826 0.127579182662649 4235 6833801 SGTC_656 4090-1979 187 µM -1.13803896826786 0.162985020853073 no 2827 0.127552105441731 4284 22330961 SGTC_1143 3454-2408 5.08 µM -1.13846348601263 0.162895703136053 no 2828 0.127463498753083 4227 X1143 SGTC_2856 9022925 19.48 µM -1.13977482362622 0.162620001261419 no 2829 0.127190062576119 4278 4944862 SGTC_1469 k284-2957 126 µM -1.1399939544136 0.16257395977943 no 2830 0.12714440990988 4223 23884841 SGTC_248 streptozotocin 5.23457 mM -1.14106567472345 0.16234890324118 no 2831 0.126921297047038 4259 5300 DNA alkylating agent. SGTC_2179 6298986 200 µM -1.14145198868381 0.162267828762035 no 2832 0.126840940303486 4217 738374 SGTC_2731 amoxapine 43.43 µM -1.14150802420647 0.162256070954872 no 2833 0.126829287357911 4367 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_48 0382-0018 55 µM -1.1419324106648 0.162167040910859 no 2834 0.126741057675643 4301 762596 SGTC_3323 9138564 53.9225 µM -1.14328482356546 0.161883536798137 no 2835 0.126460177017781 4250 43912313 YNL103W MET4 SGTC_704 1310-0270 142 µM -1.14604305990868 0.161306333696369 no 2836 0.125888667839113 4256 5718033 SGTC_1118 chelidonine 707.474 nM -1.14664389157575 0.161180778763927 no 2837 0.125764414244312 4225 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2398 5228213 48.84 µM -1.14714702426583 0.161075688911122 no 2838 0.125660430892549 4238 80771 YMR134W ERG29 SGTC_132 0417-1715 25.805 µM -1.1479787149772 0.160902070866001 no 2839 0.125488675412689 4227 6769098 SGTC_2943 9068529 45.32 µM -1.14815914067157 0.160864422567475 no 2840 0.12545143668215 4224 3270634 SGTC_2952 9073731 13.78 µM -1.14826115956303 0.160843137470355 no 2841 0.125430384037284 4285 16457353 SGTC_2306 7482397 179.52 µM -1.14999391535725 0.160481898257955 no 2842 0.125073188690159 4252 891448 SGTC_903 1134-0042 114 µM -1.15026927180509 0.160424541700336 no 2843 0.125016491391955 4245 701009 SGTC_1243 0416-0003 5.65 µM -1.15098895128839 0.160274696222177 no 2844 0.12486839049933 4231 2141977 SGTC_3103 9120822 49.47 µM -1.15115644748228 0.160239834731057 no 2845 0.124833939503091 4250 17141819 SGTC_2301 7769476 200 µM -1.15175419974352 0.160115463148352 no 2846 0.124711046611029 4251 977820 SGTC_1988 st071872 53.4 µM -1.15362056453019 0.159727543427133 no 2847 0.124327881778942 4271 16414116 SGTC_162 k030-0015 37.8 µM -1.15396038965442 0.15965697777121 no 2848 0.124258204353701 4307 1809920 YMR134W ERG29 SGTC_1453 4237-0541 195 µM -1.15488076449966 0.159465961775086 no 2849 0.124069628737824 4236 739892 SGTC_409 arachidonic acid 100 µM -1.15954222292333 0.158500814246676 no 2850 0.123117618110518 4235 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2395 5646831 180.19 µM -1.160660440014 0.158269860142015 no 2851 0.122890007857934 4272 6808628 SGTC_766 1391-0721 126 µM -1.16145074825282 0.15810676486301 no 2852 0.122729320680985 4280 1020919 YIL115C NUP159 SGTC_1152 3909-8331 15.9 µM -1.16301240182138 0.157784812145862 no 2853 0.122412235355209 4212 16001939 SGTC_1558 st069300 45.6 µM -1.16367567975422 0.15764820019721 no 2854 0.122277734453674 4195 24208000 SGTC_2262 9014885 67.46 µM -1.16481130061561 0.157414482673332 no 2855 0.122047691780218 4244 6457424 SGTC_2630 antimycin a 100 µM -1.1649519971452 0.15738554235502 no 2856 0.122019212063563 4190 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_335 4077-0256 27.6 µM -1.16651084930941 0.157065131122949 no 2857 0.121703982336643 4221 3121989 SGTC_2824 7998404 51.95 µM -1.1739638952019 0.155539142610838 no 2858 0.12020474376301 4219 837851 SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.17479874651895 0.155368820528293 no 2859 0.120037620878035 4257 140250 A respiratory chain inhibitor. SGTC_2469 5655019 90.81 µM -1.17487921672469 0.155352409915657 no 2860 0.120021520783376 4317 2788239 SGTC_550 4123-0385 25.7 µM -1.17553337090126 0.15521904807015 no 2861 0.11989069721296 4290 5731123 SGTC_260 nsc-65238 3.989 µM -1.17647450221854 0.155027313053255 no 2862 0.119702657809798 4262 3246252 SGTC_3339 9145883 14.936 µM -1.17799974323658 0.154716910657089 no 2863 0.119398354296056 4176 2030670 SGTC_2989 9073649 71.4286 µM -1.17941237225678 0.154429792512417 no 2864 0.119117005458426 4237 21367202 SGTC_2055 5235184 200 µM -1.18204875525292 0.15389488799444 no 2865 0.118593177960154 4311 2836034 SGTC_2955 9076254 12.21 µM -1.18220056091539 0.153864125017506 no 2866 0.118563065071338 4180 16459619 SGTC_1834 st055981 52.8 µM -1.18527227263434 0.153242525930857 no 2867 0.117954906339064 4274 471719 YDL150W RPC53 SGTC_3304 9125678 46.087 µM -1.18573701672001 0.153148624310668 no 2868 0.117863085641134 4204 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.18757451397737 0.15277773120591 no 2869 0.117500541835547 4287 7104 SGTC_1384 3089-0840 101 µM -1.18811477379361 0.152668794863853 no 2870 0.117394097286023 4261 1069836 SGTC_2198 6589944 200 µM -1.1911610987138 0.152055507796094 no 2871 0.11679517394208 4277 5290268 SGTC_2096 5468907 200 µM -1.19216505929179 0.151853749118364 no 2872 0.116598265458187 4281 759785 SGTC_1057 3448-5381 134 µM -1.19726646689978 0.150831305373475 no 2873 0.115601355119223 4266 5497911 SGTC_2196 6573537 42.6665 µM -1.19739528439334 0.150805546738537 no 2874 0.115576260398903 4293 2903087 SGTC_1258 0671-0043 57.1 µM -1.19852185394989 0.150580400169515 no 2875 0.115356960185889 4298 4298767 SGTC_774 k060-0086 136 µM -1.19903062728619 0.150478794497079 no 2876 0.115258018381824 4286 5911235 SGTC_57 miconazole 162.5 nM -1.20141318998147 0.150003587543118 no 2877 0.114795481080087 4145 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_280 3448-3607 3.04 µM -1.20511625312146 0.149266992307417 no 2878 0.114079213108155 4248 626179 SGTC_2038 4100038 30.985 µM -1.20637742135034 0.149016679153797 no 2879 0.113835998913323 4267 3596803 SGTC_1376 2910-0861 41.3 µM -1.21274682978264 0.147756782925175 no 2880 0.112613314745913 4230 1112859 SGTC_1098 clofazimine 15.1 µM -1.21636562364764 0.147044156766939 no 2881 0.111922836563903 4358 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_211 3455-0679 143.504 µM -1.22058917097991 0.146215359492695 no 2882 0.111120804251247 4326 748649 SGTC_1689 st020265 53.493 µM -1.22183326365702 0.145971827413397 no 2883 0.110885343356028 4312 5758320 YPR016C TIF6 SGTC_2227 7312221 64.1025 µM -1.22576008673611 0.145204937427837 no 2884 0.11014448560602 4416 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_213 1246-0773 967 nM -1.22951436275031 0.144474284470835 no 2885 0.109439508078382 4328 6251622 SGTC_2963 9082507 9 µM -1.23187154968907 0.14401679958865 no 2886 0.108998535266873 4329 16459611 SGTC_411 enrofloxacin 100 µM -1.23237130211586 0.143919932865807 no 2887 0.108905207964266 4374 71188 A bacterial gyrase inhibitor. SGTC_3238 9133470 49.47 µM -1.23258580364719 0.14387836964132 no 2888 0.108865168056394 4315 3534688 SGTC_608 k048-0125 159 µM -1.23372651768402 0.143657473439496 no 2889 0.108652414575204 4354 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_815 1582-0027 36.9 µM -1.23758636609307 0.142911722348735 no 2890 0.107934736172165 4346 3128206 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.23892491574555 0.142653716774472 no 2891 0.107686652780004 4316 688751 SGTC_3071 9117417 49.47 µM -1.2459487981016 0.141305026926071 no 2892 0.106391596673182 4267 45595590 YGL055W OLE1 SGTC_2086 5274770 176.623 µM -1.24824249895803 0.140866480477618 no 2893 0.105971132322757 4361 689278 SGTC_758 0868-0029 16 µM -1.24831448937619 0.140852731158452 no 2894 0.105957955032716 4319 762687 SGTC_1930 st074634 34.3 µM -1.25002322629748 0.140526649861526 no 2895 0.105645531466446 4219 684253 YOR116C RPO31 SGTC_2161 5662504 8.5105 µM -1.25022041037175 0.140489053881994 no 2896 0.105609521459628 4294 2859334 SGTC_116 0155-0182 31.788 µM -1.25136370135135 0.140271203597213 no 2897 0.105400907112004 4207 771486 SGTC_2518 prenyletin 46.28 µM -1.25397147932162 0.13977515906256 no 2898 0.104926186062437 4336 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2460 5552655 174.22 µM -1.25542094701536 0.139499961428689 no 2899 0.104662994567819 4348 5401989 SGTC_1962 st076595 64.5 µM -1.25547593776223 0.13948952808197 no 2900 0.104653018879115 4306 279619 SGTC_1880 MG-132 525 µM -1.2573757811118 0.139129398347608 no 2901 0.104308797395523 4284 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_320 4092-0846 5.34 µM -1.25872716555854 0.138873618653282 no 2902 0.10406444788552 4287 1359356 SGTC_3347 9188721 44.724 µM -1.26094649967977 0.138454255206328 no 2903 0.10366406165827 4344 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_521 r062-0005 13.8 µM -1.2610601913172 0.138432795395426 no 2904 0.103643580884174 4259 2832033 SGTC_806 3966-4455 5.86 µM -1.26142259079783 0.138364405983423 no 2905 0.103578316681515 4314 714982 SGTC_515 4092-1064 102 µM -1.26270252863043 0.138123049676669 no 2906 0.10334805248219 4334 717353 SGTC_3115 9123671 49.47 µM -1.26613675048864 0.13747688184396 no 2907 0.102732063612738 4483 3286988 SGTC_1751 st044839 27.194 µM -1.26649782498066 0.137409063779665 no 2908 0.102667453818065 4373 5291326 SGTC_174 3553-0389 74.3 µM -1.26656743611927 0.137395991839497 no 2909 0.102655001166133 4398 738071 SGTC_1346 1488-2224 62.4 µM -1.26803986087911 0.137119691219402 no 2910 0.102391858045223 4352 3722427 SGTC_2048 5246248 200 µM -1.27092095143207 0.136580153024435 no 2911 0.101878385997441 4355 677046 SGTC_1643 st009866 20.2 µM -1.27094197241952 0.136576221793066 no 2912 0.101874646506773 4301 3156273 YOR207C RET1 SGTC_686 1319-0111 510 µM -1.27107175139806 0.136551952944076 no 2913 0.101851561921647 4375 4562600 SGTC_2993 9054257 71.4286 µM -1.27187816061692 0.136401219401645 no 2914 0.101708206282338 4260 6470217 YGL055W OLE1 SGTC_833 3852-0053 558 µM -1.27247768406518 0.136289230620729 no 2915 0.10160172404031 4393 3123681 SGTC_1704 st028805 70.8 µM -1.27584044930134 0.135662244630037 no 2916 0.101005962791001 4384 2876101 SGTC_2647 atorvastatin 60.16 µM -1.27641181071885 0.135555911257624 no 2917 0.100904991675553 4318 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_105 0111-0055 734.78 µM -1.27781452054697 0.135295101797594 no 2918 0.100657416633593 4361 5179370 SGTC_1285 0929-0069 65.5 µM -1.28118080486495 0.1346706038261 no 2919 0.100065083340248 4383 1206237 SGTC_2801 7907800 81.82 µM -1.28198452025596 0.13452179515987 no 2920 0.0999240382485095 4359 6620925 SGTC_3274 9138298 49.47 µM -1.28279769487835 0.134371350025027 no 2921 0.0997814809687251 4327 17015756 SGTC_1965 Pectolinarigenin 58.4 µM -1.28466607894126 0.134026118794576 no 2922 0.0994544983613279 4340 5320438 An anti-inflammatory. SGTC_1068 loratadine 26.9 µM -1.28467615009587 0.134024259546833 no 2923 0.0994527379510594 4406 3957 A H1 histamine antagonist. SGTC_2457 5731572 11.68 µM -1.28511339663755 0.133943556032913 no 2924 0.0993763304106854 4400 2865357 SGTC_2051 5263410 176 µM -1.28532849189645 0.133903867705884 no 2925 0.0993387589016437 4313 227584 SGTC_2996 9066192 71.4286 µM -1.28815483830206 0.133383114835159 no 2926 0.0988460346144156 4365 6472854 SGTC_2131 toluylene red 5.2905 µM -1.29214343953113 0.132650590138163 no 2927 0.0981537373846346 4325 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_695 3505-6186 243 µM -1.2921859568383 0.132642796598492 no 2928 0.0981463768844974 4351 1819379 SGTC_3019 9081971 49.47 µM -1.29296387218882 0.132500258247606 no 2929 0.0980117773117193 4383 16451803 SGTC_3328 9140624 29.0385 µM -1.2947483195264 0.132173690677019 no 2930 0.0977035326606539 4373 4904392 SGTC_1367 1812-0510 76.9 µM -1.29584742460911 0.131972822385538 no 2931 0.0975140277801721 4416 1142582 YDR527W RBA50 SGTC_616 4092-0450 108 µM -1.29741157147569 0.131687327985465 no 2932 0.097244806584674 4366 787165 SGTC_2733 amorolfine 100 µM -1.29873641281089 0.131445846192536 no 2933 0.0970172016333351 4517 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2770 toltrazuril 17.5 µM -1.29879725797537 0.131434763155499 no 2934 0.0970067579621092 4316 68591 Kills coccidiodes. SGTC_790 1575-0012 79.1 µM -1.29917564442513 0.131365853983279 no 2935 0.0969418289469982 4402 378741 YLR208W SEC13 SGTC_719 2810-4230 27.3 µM -1.30021632910685 0.131176460217066 no 2936 0.0967634177837915 4381 721079 SGTC_699 0375-0592 111 µM -1.30099802079429 0.13103432457016 no 2937 0.0966295660967504 4441 762578 SGTC_1500 4488-1866 171 µM -1.30132479033384 0.13097493934252 no 2938 0.0965736525819373 4422 2900003 SGTC_2765 myclobutanil 7.74 µM -1.303063916918 0.130659193298168 no 2939 0.0962764705687163 4378 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1269 0831-0796 3.05 µM -1.30591021705385 0.130143571243139 no 2940 0.0957915458393962 4397 927758 SGTC_1363 1636-0063 10.4 µM -1.30870696238008 0.129638299529828 no 2941 0.0953168162007989 4374 6072185 SGTC_736 0958-0254 92.6 µM -1.31081543816334 0.129258272917482 no 2942 0.0949600627296289 4438 6812352 SGTC_2726 cimetidine 79.27 µM -1.3118868267067 0.129065464577243 no 2943 0.0947791614628219 4351 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2515 chrysin 20.77 µM -1.31630489899924 0.128272490267029 no 2944 0.0940358636147763 4385 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1642 st009582 77.7 µM -1.32140832326971 0.127360724738122 no 2945 0.0931826261403849 4349 6739311 SGTC_961 1252-1571 372 µM -1.32319178121027 0.127043161877143 no 2946 0.0928858042468331 4394 6813498 SGTC_563 tetrahydrosecaminediol 614 µM -1.32866184509985 0.126072599916424 no 2947 0.091979779128272 4424 334274 A psychoactive constituent of the cannabis plant. SGTC_1731 st035964 63 µM -1.33098542926533 0.12566189105783 no 2948 0.0915969026760431 4303 6739575 SGTC_2675 theaflavin digallate 100 µM -1.33500189011064 0.124954158324164 no 2949 0.0909378639170047 4324 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1658 st012944 20 µM -1.34134555293273 0.123842034505539 no 2950 0.0899041431669706 4236 24207260 SGTC_689 0833-0039 98 µM -1.34390324545773 0.123395604664574 no 2951 0.0894898382071828 4350 5374726 SGTC_380 3970-0968 6 µM -1.34483183647426 0.123233803988643 no 2952 0.0893397733090823 4277 2891601 SGTC_3154 9100113 49.47 µM -1.34689772399538 0.122874370589682 no 2953 0.0890065873355685 4389 25237525 SGTC_2875 9039966 71.43 µM -1.34702423711316 0.122852383119633 no 2954 0.0889862134181183 4386 6463691 SGTC_667 1498-1044 59 µM -1.34926732929128 0.122463000799089 no 2955 0.08862555772614 4403 6739982 SGTC_165 k038-0023 64.381 µM -1.3504452897362 0.122258863754246 no 2956 0.0884365958518008 4393 46368543 SGTC_1261 0712-0010 12.7 µM -1.35082682189684 0.122192796608123 no 2957 0.0883754569874442 4383 2840123 SGTC_1825 st052143 62.6 µM -1.35848004491181 0.120872835369195 no 2958 0.0871557051687529 4452 674173 SGTC_1507 4075-3230 155 µM -1.35890822076951 0.120799284876138 no 2959 0.0870878367648394 4359 659771 SGTC_1728 st035614 33.7865 µM -1.3620198999751 0.120265718152436 no 2960 0.0865958024905618 4343 15945546 SGTC_1031 k035-0009 16 µM -1.36354000215474 0.120005667320905 no 2961 0.0863561931650058 4434 5180959 SGTC_1603 st002045 67.8 µM -1.3640447246467 0.119919409846031 no 2962 0.0862767449498243 4405 5887985 SGTC_449 xestospongin c 11.1929 µM -1.36483834076814 0.119783868628959 no 2963 0.0861519326494964 4426 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2002 4023503 131 µM -1.36570261834547 0.119636382103586 no 2964 0.0860161610932692 4396 4736863 YCR052W RSC6 SGTC_1254 0550-0035 264 µM -1.36664331981802 0.119475999678901 no 2965 0.0858685659432948 4415 15121435 SGTC_628 1636-0253 16 µM -1.36714536707558 0.119390466559249 no 2966 0.0857898728291457 4400 4456143 SGTC_1208 2323-2347 50.3 µM -1.36919035826616 0.119042510619135 no 2967 0.0854698895540249 4426 5412760 SGTC_884 0851-0618 334 µM -1.37136212602804 0.118673768237103 no 2968 0.0851310489164883 4428 9642473 SGTC_1941 st076221 61.8 µM -1.3732938370779 0.118346463614993 no 2969 0.0848305088724508 4288 2828568 SGTC_1061 3448-9325 110 µM -1.37366140010706 0.118284256927826 no 2970 0.0847734127675312 4373 723482 SGTC_1005 4092-0690 4.4 µM -1.37785437144161 0.117576270495981 no 2971 0.084124127511838 4427 1529343 SGTC_3081 9117243 49.47 µM -1.37834502656417 0.117493619476802 no 2972 0.084048393786933 4391 45595589 SGTC_2393 9031399 185.94 µM -1.37839400294732 0.117485371647274 no 2973 0.0840408369824554 4419 1526623 YDL150W RPC53 SGTC_1353 1498-1206 8.11 µM -1.38348137241683 0.116630868960893 no 2974 0.0832586575491567 4448 6756808 SGTC_1448 4255-0083 152 µM -1.38532682697161 0.11632198820426 no 2975 0.0829762771377451 4443 5399660 SGTC_1561 5-methoxyflavone 52.9 µM -1.38562168090824 0.116272691201548 no 2976 0.0829312271766875 4387 94525 SGTC_2239 6685329 187.64 µM -1.3913223001177 0.115322510109222 no 2977 0.082063857241389 4455 805680 SGTC_1087 pterostilbene 9.05 µM -1.39133333487968 0.115320676199288 no 2978 0.0820621849155271 4428 5281727 Similar to reservatol, lowers cholesterol. SGTC_812 4251-0442 148 µM -1.39146749077907 0.11529838196745 no 2979 0.0820418555490526 4452 5723007 SGTC_2722 naftopidil 47.16 µM -1.39353617465328 0.114954992711705 no 2980 0.081728856913377 4364 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.39437492780928 0.114815972114271 no 2981 0.0816022076062005 4402 16623 A steroid. SGTC_2298 7976326 193.81 µM -1.39473175368293 0.11475686567004 no 2982 0.0815483728181826 4368 2235818 SGTC_1447 4239-0816 81.9 µM -1.39911301743712 0.114032895263383 no 2983 0.0808895473590929 4445 1341554 SGTC_2908 7930301 100 µM -1.404956806077 0.113072326491268 no 2984 0.0800170614541155 4400 2223178 SGTC_1177 0983-0204 23.6 µM -1.40547290296499 0.112987771745839 no 2985 0.0799403507237384 4459 766818 SGTC_921 1561-0023 372 µM -1.40711535539128 0.112718980882471 no 2986 0.07969659276184 4432 24050882 SGTC_2586 curcumin 80 µM -1.41191948640084 0.111935396390714 no 2987 0.0789868346747633 4336 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2649 anisomycin 9.56 µM -1.41714934424446 0.111086809845294 no 2988 0.0782196341733425 4488 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_572 0960-0087 17.7 µM -1.41919980449984 0.110755366553128 no 2989 0.077920386477691 4399 6796365 SGTC_488 nitrendipine 139 µM -1.41943252458207 0.110717793719814 no 2990 0.0778864778783819 4473 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1179 1021-1431 9.29 µM -1.42488989817361 0.109839313881201 no 2991 0.0770945150902997 4471 2840958 SGTC_106 0092-0003 11.579 µM -1.42997779804975 0.109024825059356 no 2992 0.0763616956682077 4350 1072148 SGTC_2511 berberine 10.47 µM -1.4365868430788 0.107973320155293 no 2993 0.0754177121286295 4443 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2258 7960471 200 µM -1.43765796408384 0.107803593862314 no 2994 0.0752655628456739 4461 2974708 SGTC_860 0443-0016 25.1 µM -1.43919193082678 0.107560861370247 no 2995 0.0750480754911737 4482 5337942 SGTC_288 1315-0019 35.1 µM -1.44060249592478 0.107338003577364 no 2996 0.0748485074483356 4507 6811474 SGTC_3203 9113543 49.47 µM -1.44424134176679 0.106764632996793 no 2997 0.0743355497404689 4486 17018012 SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.44689406161929 0.106348040795125 no 2998 0.0739632982973623 4510 5282309 SGTC_235 0330-0087 5 mM -1.44729895006408 0.106284559128725 no 2999 0.0739066065353237 4506 46494818 YHR062C RPP1 SGTC_1829 berberine 14.4 µM -1.45157066327304 0.105616472572634 no 3000 0.0733105104207918 4430 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_972 1319-0219 195 µM -1.45402484667748 0.105234019825078 no 3001 0.0729697088355433 4458 23903702 SGTC_1927 st060202 13.8 µM -1.45456073203466 0.105150642482878 no 3002 0.0728954543658407 4395 688887 SGTC_169 k015-0017 16.025 µM -1.45557511564705 0.104992947458007 no 3003 0.0727550556125604 4454 1840002 SGTC_985 1493-0307 8.71 µM -1.4556978196126 0.104973883639462 no 3004 0.072738086456024 4504 3278274 SGTC_2023 5144124 124 µM -1.45958099300877 0.104371870880558 no 3005 0.0722026330702972 4445 2830192 SGTC_40 0327-0103 19.753 µM -1.46032334498486 0.104257068645147 no 3006 0.0721006145042384 4323 409036 SGTC_3064 1327-0027 10 µM -1.46277845561677 0.103878045976678 no 3007 0.0717640050603152 4423 16000455 YPR107C YTH1 SGTC_1145 3546-0597 10.2 µM -1.46611943585574 0.103363868572225 no 3008 0.0713078758298805 4440 875334 SGTC_1106 tegaserod maleate 11.7 µM -1.46882015358422 0.10294958003916 no 3009 0.0709407881019501 4498 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1081 sertraline 6 µM -1.46905835363971 0.102913098260937 no 3010 0.0709084811934119 4461 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_299 1273-0059 1.44 µM -1.46956471562524 0.10283557706916 no 3011 0.0708398412187372 4268 2848077 SGTC_2802 7925815 54.55 µM -1.4708008696572 0.10264650703767 no 3012 0.070672488600898 4457 1262923 SGTC_1370 2001-0092 44.6 µM -1.47092381179224 0.102627716834362 no 3013 0.0706558611125127 4467 790957 SGTC_398 bronopol 33.3 µM -1.47159429630978 0.102525285465881 no 3014 0.0705652333588379 4409 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.47254866753006 0.102379612336821 no 3015 0.0704363874735198 4509 94937 An inhibitor of serotonin biosynthesis. SGTC_2338 7999974 200 µM -1.47676971359142 0.101737126042906 no 3016 0.069868688823149 4468 315925 SGTC_2458 5808907 16.39 µM -1.47688498586387 0.101719621695276 no 3017 0.0698532351167088 4590 2731747 SGTC_2014 4013930 200 µM -1.47743716225217 0.101635802905873 no 3018 0.0697792453643703 4461 64556 SGTC_526 4469-0568 170 µM -1.47744914484626 0.101633984540206 no 3019 0.0697776404066151 4436 2901964 SGTC_2520 obtusaquinone 4.71 µM -1.47945603622881 0.101329771732135 no 3020 0.0695092365261974 4512 5967872 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.4797737775429 0.101281668097509 no 3021 0.0694668144492486 4434 1241132 A phosphatase inhibitor. SGTC_1909 st060837 51.5 µM -1.47984927875133 0.101270240231811 no 3022 0.0694567371121656 4440 678937 SGTC_891 0929-0073 133 µM -1.48387708314741 0.100661952850662 no 3023 0.0689207662900288 4513 5603632 SGTC_351 caspofungin 25 nM -1.48395800666591 0.100649758981983 no 3024 0.0689100307437291 4469 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_362 0310-0100 9.03 µM -1.48534619235211 0.100440749537614 no 3025 0.0687260707061415 4513 790235 SGTC_514 4466-0038 2.65 nM -1.48661828671443 0.10024949739513 no 3026 0.068557827621581 4271 5722064 SGTC_65 0798-0905 34.986 µM -1.48663109447668 0.100247573173565 no 3027 0.0685561353252297 4488 3602145 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.48816945094712 0.10001664853764 no 3028 0.0683531057418741 4491 6708561 SGTC_778 3456-2434 196 µM -1.49575394048955 0.0988838082751839 no 3029 0.0673588940579471 4423 5539063 SGTC_1652 st011932 78 µM -1.49676159608741 0.0987340113840862 no 3030 0.0672276511866479 4424 1551076 SGTC_2182 6325192 200 µM -1.49885782603995 0.0984229205484315 no 3031 0.0669552596569283 4523 736248 SGTC_2188 6126565 140.678 µM -1.50034245199216 0.0982030293343204 no 3032 0.0667628591008424 4403 874518 SGTC_1451 4152-0210 104 µM -1.50169265646884 0.098003360243877 no 3033 0.0665882506511 4527 659563 SGTC_2206 7254556 146.969 µM -1.50407665173517 0.0976515401570294 no 3034 0.0662808156563609 4524 4398905 SGTC_1275 0867-0008 21.1 µM -1.50556928903883 0.097431734904287 no 3035 0.0660888886096322 4474 3422836 SGTC_281 1672-3440 14.9 µM -1.50879497235361 0.0969579619106491 no 3036 0.0656755929920922 4538 6833000 SGTC_1033 k072-0102 21.3 µM -1.50880141897086 0.0969570167586372 no 3037 0.0656747690203104 4458 5965931 SGTC_255 tunicamycin 200.472 nM -1.51067802903383 0.09668217052366 no 3038 0.0654352514186337 4420 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2805 7950783 58.44 µM -1.51702789269304 0.0957564208644005 no 3039 0.0646298209613236 4504 1178958 YDL195W SEC31 SGTC_1025 k007-0731 70 µM -1.52155049206219 0.095101056454985 no 3040 0.0640608752915315 4480 6256118 SGTC_2774 tamoxifen 10.92 µM -1.52611154609951 0.0944434714054077 no 3041 0.0634910435370205 4489 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.52756497672603 0.0942346306479059 no 3042 0.0633102915171351 4495 688669 SGTC_1740 st038286 13.222 µM -1.52911973895071 0.0940116070402328 no 3043 0.0631173814083712 4510 716786 SGTC_265 mycophenolic acid 32.932 µM -1.53154453045579 0.0936645594392646 no 3044 0.0628174348270071 4559 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1491 4138-0063 26.5 µM -1.53273873856196 0.0934939868006436 no 3045 0.0626701201255366 4516 23883227 SGTC_2141 5621638 7.665 µM -1.53539022346956 0.0931160869422832 no 3046 0.0623440018735281 4528 2856238 SGTC_1524 corynanthine 62.1 µM -1.53578666268104 0.0930596820448346 no 3047 0.0622953559380493 4578 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1684 st024538 14.6195 µM -1.5364697926931 0.0929625463808945 no 3048 0.0622116004478524 4487 6732859 SGTC_1523 st012844 44.7 µM -1.53871470309091 0.0926438658284373 no 3049 0.0619369806245804 4547 4274103 SGTC_1830 st055982 50.3 µM -1.54188522191525 0.0921951662711477 no 3050 0.0615507438547023 4524 455313 An antimicrobial agent. SGTC_1139 k015-0024 46.9 µM -1.54271553069784 0.0920779251910258 no 3051 0.0614499059887032 4538 2766652 SGTC_83 0170-0301 39.027 µM -1.54370294273361 0.0919386445863011 no 3052 0.0613301565482236 4544 3089716 SGTC_649 1123-0311 367 µM -1.54509546747623 0.0917424855788935 no 3053 0.0611615865865407 4414 693629 YIL048W NEO1 SGTC_1432 4049-0298 68.4 µM -1.54980957351799 0.0910807310602952 no 3054 0.0605936142667062 4533 741646 SGTC_84 0443-0269 128.823 µM -1.55144794441612 0.0908515716099347 no 3055 0.060397186547565 4470 6150058 SGTC_2307 7538926 6.34 µM -1.55515019585876 0.0903353126007285 no 3056 0.0599551512734582 4480 96582 SGTC_827 3253-0474 693 µM -1.55537163693943 0.0903045030286454 no 3057 0.0599287925372941 4524 5402065 SGTC_2854 9024559 71.43 µM -1.55541091063901 0.0902990396095317 no 3058 0.0599241186293883 4518 3163529 SGTC_3144 9087057 49.47 µM -1.55759562569267 0.089995507368445 no 3059 0.059664568145494 4450 17249618 SGTC_94 0334-0113 514.748 µM -1.56450487774566 0.0890405646485831 no 3060 0.0588495241856044 4543 6795178 SGTC_2250 alverine citrate 130 µM -1.5662722250484 0.0887975114634048 no 3061 0.0586424502307019 4405 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1219 1469-0211 33.1 µM -1.56835244687023 0.0885120637981229 no 3062 0.0583994511737934 4526 6822282 SGTC_101 0490-5701 117.494 µM -1.56901272590086 0.08842160350753 no 3063 0.058322486888701 4404 4661669 SGTC_483 fpl-64176 144 µM -1.58658874421924 0.0860388882542695 no 3064 0.0563029091780671 4652 3423 SGTC_3042 9091578 49.47 µM -1.58835209749648 0.0858025144619444 no 3065 0.0561033715078506 4527 25236497 SGTC_2089 5281248 129.67 µM -1.59067469582803 0.0854919172411268 no 3066 0.05584140223982 4523 2737878 SGTC_2475 5812728 15.03 µM -1.59169045693108 0.0853563461494316 no 3067 0.0557271368181271 4496 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_3291 9121177 71.43 µM -1.59246250298293 0.0852534108627456 no 3068 0.0556404109722125 4516 17015612 SGTC_3217 9129673 49.47 µM -1.59417549369257 0.0850253535403557 no 3069 0.0554483668757845 4506 17248312 SGTC_3254 9136651 49.47 µM -1.59433985764813 0.0850034951729507 no 3070 0.0554299675152493 4512 16454030 SGTC_1897 st060201 15 µM -1.59626232251033 0.0847481438554445 no 3071 0.0552151191836465 4545 611878 SGTC_1333 1482-0047 286 µM -1.59707735100184 0.0846400615198984 no 3072 0.0551242330633603 4580 3811116 SGTC_318 1488-0629 67.2 µM -1.59926439973489 0.0843505441717849 no 3073 0.0548809331225316 4580 3662576 SGTC_1292 0kpi-0043 232 µM -1.59962507328576 0.0843028703604069 no 3074 0.0548408913588823 4559 3333905 SGTC_1964 st076914 61 µM -1.60078531535676 0.0841496467723852 no 3075 0.0547122385764267 4571 24208661 SGTC_297 0986-0032 24 µM -1.60271730730141 0.0838949685745933 no 3076 0.0544985403369624 4514 2847425 SGTC_522 1273-0010 11.6 µM -1.60886836203309 0.0830879820411975 no 3077 0.0538225643936342 4551 5705015 SGTC_876 0720-0963 56.8 µM -1.6090167771052 0.0830685831332072 no 3078 0.0538063365864788 4561 765861 SGTC_3294 9122953 26.2835 µM -1.61031901571816 0.082898517303957 no 3079 0.0536641150037242 4532 16459826 SGTC_3070 9117005 49.47 µM -1.61415166387515 0.0823995125899699 no 3080 0.0532472667238949 4651 8779016 SGTC_1510 1123-0200 71.5 µM -1.61493107554601 0.0822983117332203 no 3081 0.0531628108701328 4551 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2256 7954252 200 µM -1.61786638972038 0.0819180227918135 no 3082 0.0528456974871476 4565 2972920 SGTC_603 3794-0023 45.9 µM -1.6236754086897 0.0811693326036145 no 3083 0.0522225510243733 4590 3802260 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.63008600794595 0.0803491139901192 no 3084 0.0515416602520291 4509 676296 Flavone; oxidizing agent. SGTC_670 4204-0025 119 µM -1.63152075211621 0.0801664030773373 no 3085 0.0513902423449364 4573 719039 SGTC_2769 toremifene 3.73 µM -1.63313115886202 0.0799616962698835 no 3086 0.051220707293701 4553 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1818 st052136 56.3 µM -1.63402425293228 0.079848341153966 no 3087 0.0511268791004254 4198 674169 SGTC_591 4299-0174 154 µM -1.63536885893153 0.0796779076001288 no 3088 0.0509858732348218 4598 5509088 SGTC_2832 7992762 51.95 µM -1.6363777815679 0.0795502039288848 no 3089 0.0508802731555685 4483 2985177 SGTC_3240 9133527 49.47 µM -1.63640224519812 0.0795471093864583 no 3090 0.0508777148046901 4553 17617455 SGTC_2 0422-0095 29 µM -1.63857720508895 0.0792723503502482 no 3091 0.0506506714473875 4485 6790840 SGTC_1209 2323-2347 50.3 µM -1.64517479145627 0.0784432833763297 no 3092 0.0499668852412154 4580 5412760 SGTC_715 0868-0130 184 µM -1.65024747234342 0.0778103222593116 no 3093 0.0494461654596185 4609 2876258 SGTC_2641 levomentholum 100 µM -1.65209148973388 0.077581191885019 no 3094 0.0492579507810285 4581 16666 SGTC_743 1275-0778 158 µM -1.653321401953 0.0774286528501805 no 3095 0.0491327347671194 4543 2849257 YMR203W TOM40 SGTC_2274 7947094 46.08 µM -1.65608051768447 0.0770872841838953 no 3096 0.0488527570816867 4537 2971028 SGTC_1476 4112-3294 3.34 µM -1.67145957302386 0.0752054487428137 no 3097 0.047315468735859 4558 704369 SGTC_1356 1502-0781 85.8 µM -1.67314260961537 0.0750016513486828 no 3098 0.0471496125363999 4589 567702 SGTC_2810 7959871 45.46 µM -1.68725670122601 0.0733091327950871 no 3099 0.045777001405374 4526 2974535 SGTC_3228 9131799 49.47 µM -1.6877946721557 0.0732452038113702 no 3100 0.0457253253493047 4603 17015818 SGTC_3109 9122853 49.47 µM -1.6891191615724 0.0730879918322064 no 3101 0.0455982982377729 4601 1234709 SGTC_1342 1486-1464 234 µM -1.68991532220568 0.072993614858575 no 3102 0.0455220779076567 4599 3253938 SGTC_661 1304-0007 33.6 µM -1.69045762574276 0.0729293835584517 no 3103 0.0454702192338429 4601 3117130 SGTC_3249 9135183 49.47 µM -1.69248227908074 0.0726899626128022 no 3104 0.0452770280557913 4543 4902779 SGTC_1691 st019933 84.6 µM -1.69451052185061 0.0724507211781519 no 3105 0.0450841570070563 4585 6176082 SGTC_1206 3978-0017 132 µM -1.69754019655368 0.0720944799585195 no 3106 0.0447972891420801 4596 3873677 SGTC_1717 st033143 58.0435 µM -1.69860900371952 0.0719691262709298 no 3107 0.044696439431968 4584 674616 SGTC_898 1000-0849 28.3 µM -1.70375108421968 0.0713683788371669 no 3108 0.0442138000152717 4597 6751807 SGTC_2236 dapsone 200 µM -1.70663463651071 0.0710331829856477 no 3109 0.0439449915691721 4616 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2197 6588183 93.1375 µM -1.70849367663853 0.0708177224691112 no 3110 0.0437723893490388 4619 884136 SGTC_1635 st007035 42.4 µM -1.71054857534918 0.070580146814827 no 3111 0.0435822395074245 4547 3716403 SGTC_1968 st069590 43.6 µM -1.71740383487228 0.0697920101637866 no 3112 0.0429527057389191 4563 6384066 SGTC_151 3013-0144 2.285 µM -1.71782485590039 0.0697438278234121 no 3113 0.0429142831806555 4359 906558 YHR107C CDC12 SGTC_1686 st019653 115.5 µM -1.71925504183677 0.0695803461906235 no 3114 0.0427839711779796 4587 97252 SGTC_1405 3909-7894 12 µM -1.72431083080846 0.0690047937043273 no 3115 0.0423258725453753 4592 7104060 SGTC_1052 3253-3998 198 µM -1.72449065969008 0.0689843897156832 no 3116 0.0423096518447095 4559 5450317 SGTC_395 anisomycin 6.25 µM -1.72700560708202 0.0686995223907982 no 3117 0.0420833282426183 4598 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_552 k242-0005 476 µM -1.72966926994393 0.0683988002032715 no 3118 0.0418446910505161 4640 4088318 SGTC_3107 9121808 49.47 µM -1.73008521691724 0.0683519324489573 no 3119 0.0418075255239429 4556 662681 SGTC_3317 9138495 8.753 µM -1.73116154180835 0.0682307701627994 no 3120 0.0417114782448241 4526 17020139 SGTC_245 methotrexate 289.6 µM -1.73261251541026 0.0680676959683005 no 3121 0.0415822816336189 4554 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3344 9148862 3.898 µM -1.73380126950773 0.0679343168694537 no 3122 0.0414766751698332 4632 4905352 SGTC_463 ikarugamyin 104 µM -1.73466080485556 0.067838002145234 no 3123 0.0414004512872399 4734 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1172 0370-0043 85 µM -1.74475044865748 0.066715283422956 no 3124 0.0405141587801056 4626 376585 SGTC_430 0958-0115 16.4 µM -1.74620970022356 0.0665541032423961 no 3125 0.0403872599366882 4533 6833180 SGTC_2681 menadione 3.18 µM -1.74834733064904 0.0663185377927374 no 3126 0.0402019510724942 4631 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1026 k007-1105 30.6 µM -1.7519644607933 0.0659214037461372 no 3127 0.0398899595629687 4581 7066794 SGTC_619 1652-1634 108 µM -1.75211196533629 0.0659052480360572 no 3128 0.0398772786050236 4602 5400454 SGTC_3113 9123498 49.47 µM -1.76293700813437 0.0647279692248112 no 3129 0.0389555572023373 4688 8897275 SGTC_2309 7664088 163.95 µM -1.76573983583592 0.0644258249408189 no 3130 0.0387197531426222 4582 704922 SGTC_1715 st032160 10.2275 µM -1.77354488035419 0.0635902162539135 no 3131 0.0380692309742024 4530 5289825 SGTC_3329 9141233 27.5565 µM -1.77440391347983 0.0634987656454708 no 3132 0.0379981815012445 4588 4909101 YNL103W MET4 SGTC_29 0299-0004 12.984 µM -1.78216856798848 0.0626767964120488 no 3133 0.0373608734326521 4552 16871 A napthoquinone isolated from Swertia calycina. SGTC_327 1273-0057 3.96 µM -1.78323729171292 0.0625643131336341 no 3134 0.0372738421924453 4542 3108138 SGTC_997 3996-0078 137 µM -1.78407527355427 0.0624762255811033 no 3135 0.0372057172713642 4654 735687 SGTC_1929 genistein trimethyl ether 50.5 µM -1.78560995265584 0.0623151528665059 no 3136 0.0370812171502979 4578 136420 SGTC_3340 9146634 11.102 µM -1.78830456290114 0.0620331229792417 no 3137 0.0368634420541433 4613 4907387 SGTC_949 1165-0505 146 µM -1.78961439615731 0.0618963902280966 no 3138 0.0367579612761585 4604 6244267 SGTC_1382 3002-2117 298 µM -1.79233030124376 0.0616136280390263 no 3139 0.0365400361141402 4656 1497314 SGTC_1115 galangin 695.678 nM -1.79516297853373 0.0613197840034302 no 3140 0.0363138685211352 4686 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1221 2958-7315 257 µM -1.80074201534849 0.0607442527702252 no 3141 0.0358717759936812 4664 4562705 SGTC_392 N-ethylmaleimide 8.33 µM -1.80272670384509 0.0605405348631938 no 3142 0.0357155731041233 4607 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1775 st081588 35.1725 µM -1.81028806711997 0.0597692943568302 no 3143 0.0351255632891442 4599 1426443 YGL099W LSG1 SGTC_553 k007-0256 45.7 µM -1.81469719642896 0.0593231395426987 no 3144 0.034785228073246 4669 6287000 SGTC_2326 6164455 177.58 µM -1.82113905323846 0.0586759948670766 no 3145 0.0342928610603016 4552 2888790 SGTC_2117 5521686 200 µM -1.82507944690136 0.0582828853095343 no 3146 0.0339945206314998 4629 803312 SGTC_480 am 92016 50 µM -1.82653402096053 0.0581382950395183 no 3147 0.0338849307605835 4645 2129 K+ channel blocker. SGTC_2928 9011484 9.79 µM -1.82844981291986 0.0579482881687428 no 3148 0.0337410356200938 4608 2994751 SGTC_1856 st057054 55.7 µM -1.83026197421547 0.0577690088338068 no 3149 0.0336053872812559 4610 1266018 SGTC_3188 9110789 49.47 µM -1.83065583620609 0.0577301013359662 no 3150 0.0335759644145693 4601 849217 SGTC_2176 5809774 33.9695 µM -1.83080687133263 0.0577151868586093 no 3151 0.0335646871889507 4570 2870539 SGTC_431 k089-0097 107 µM -1.83240687034593 0.0575573755061852 no 3152 0.0334454126191201 4340 5499420 SGTC_1792 st045773 43.6 µM -1.83407206370004 0.0573934945223865 no 3153 0.0333216488337607 4617 2919270 SGTC_417 st075190 100 µM -1.83525071673003 0.0572777187451808 no 3154 0.0332342748158268 4620 222757 SGTC_393 acivicin 6.25 µM -1.84115666021814 0.0567003598446673 no 3155 0.0327993022257379 4515 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2139 5578692 56.4705 µM -1.84536681342936 0.0562915859142676 no 3156 0.0324920986501223 4624 650991 YMR113W FOL3 SGTC_2825 7998094 58.44 µM -1.8456192874016 0.0562671466367853 no 3157 0.03247375199388 4602 2987815 SGTC_1780 st038448 24.544 µM -1.84835943622162 0.0560024401734603 no 3158 0.0322751813586821 4650 728868 YDL195W SEC31 SGTC_1871 st057448 67.3 µM -1.85172259908969 0.055678892421728 no 3159 0.0320328335633959 4633 691747 SGTC_2707 st078556 66.6 µM -1.8550241966115 0.0553627042143236 no 3160 0.0317963856782998 4574 17250899 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.85753758030546 0.0551229537440992 no 3161 0.0316173548615489 4636 23847180 SGTC_3106 9121286 49.47 µM -1.86116053089888 0.0547788063755975 no 3162 0.031360755129169 4593 15943471 SGTC_1089 terbinafine 2.25 µM -1.86120944343745 0.0547741717759015 no 3163 0.0313573026572771 4662 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2466 5983409 37.09 µM -1.87470529682555 0.0535071995976833 no 3164 0.0304166389005491 4649 2879657 SGTC_2894 9048625 32.47 µM -1.87540038733582 0.0534425795345303 no 3165 0.030368830947625 4655 4092861 SGTC_2228 7354201 200 µM -1.87698670982531 0.0532953364510268 no 3166 0.0302599577008651 4722 753451 SGTC_3147 9097027 49.47 µM -1.88111564943524 0.0529135941011559 no 3167 0.0299780943177104 4655 25236841 SGTC_2273 7815444 169.05 µM -1.88329304751339 0.0527131573232802 no 3168 0.0298303325550259 4587 2824616 SGTC_1924 st058459 75.1 µM -1.89935681017303 0.0512529919216943 no 3169 0.028758789035721 4627 688683 SGTC_254 nsc-64875 3.808 µM -1.89982587882101 0.051210842980785 no 3170 0.0287279868090662 4648 56993 SGTC_2162 5663267 200 µM -1.9036350866068 0.0508695808343869 no 3171 0.0284788629620075 4665 6456493 SGTC_840 0245-0196 390 µM -1.90603900725573 0.0506551500860634 no 3172 0.0283225724863667 4711 3827528 SGTC_312 4092-0653 6.84 µM -1.90946230394167 0.050351033812769 no 3173 0.0281012400556543 4558 1148278 SGTC_682 0kpi-0099 17 µM -1.91198268738774 0.05012806121898 no 3174 0.027939207338793 4659 1714895 YML126C ERG13 SGTC_2812 7970281 58.44 µM -1.91414771904374 0.0499371549565812 no 3175 0.0278006418561947 4669 2233435 SGTC_1248 0469-0687 58.6 µM -1.91428472385039 0.0499250938005479 no 3176 0.0277918926269698 4617 4017482 SGTC_2781 5567276 71.43 µM -1.91444111734911 0.0499113286096537 no 3177 0.0277819080257061 4626 2853274 SGTC_2592 piperlongumine 83.33 µM -1.91637268477069 0.049741568461662 no 3178 0.0276588375491774 4642 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2109 5483026 200 µM -1.91733130343034 0.0496574893082818 no 3179 0.027597927745748 4665 759335 SGTC_201 4262-0159 12.803 µM -1.92387570791911 0.0490865141391897 no 3180 0.0271850824075955 4707 1341029 SGTC_3285 9112818 20.8695 µM -1.94379054150735 0.0473812231644907 no 3181 0.0259603574155712 4661 17017947 YPR165W RHO1 SGTC_814 3342-0569 96 µM -1.94480878219548 0.0472953240048683 no 3182 0.0258989983700911 4696 4346283 SGTC_216 k038-0035 28.382 µM -1.94483122417355 0.0472934321979438 no 3183 0.0258976473873682 4638 4444231 YPR107C YTH1 SGTC_2419 paclitaxel 166.5 µM -1.94564162441129 0.0472251579561602 no 3184 0.0258489016665222 4611 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_690 glyoxal 20.3 µM -1.95500394985092 0.0464421198615536 no 3185 0.0252913020327417 4492 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1298 1079-1278 263 µM -1.95948328291791 0.0460711849679331 no 3186 0.025028107877729 4652 2840950 SGTC_1886 st057356 49.9 µM -1.9750853491938 0.0447977189618209 no 3187 0.0241292315794366 4674 24207747 SGTC_73 0327-0325 16.231 µM -1.97706451329823 0.0446382218707627 no 3188 0.024017169192882 4509 53298 SGTC_374 0880-0231 82.3 µM -1.98148899300045 0.0442833154515084 no 3189 0.0237682312642311 4564 6833587 SGTC_103 0844-0104 51.839 µM -1.98206495168825 0.0442372831060876 no 3190 0.0237359857977621 4499 5375804 SGTC_2916 7875993 68.79 µM -1.98852920487773 0.0437232818819845 no 3191 0.0233765961706844 4603 1299250 SGTC_524 r073-0010 27.8 µM -2.00072030649249 0.0427670322758772 no 3192 0.022711269907127 4648 2772106 SGTC_3077 9117319 49.47 µM -2.01216120421345 0.0418850723356694 no 3193 0.0221014733121432 4650 17154678 SGTC_80 0159-0065 512.242 µM -2.01723480606075 0.0414986985907502 no 3194 0.0218355077087971 4670 1548079 SGTC_875 0709-0210 25.7 µM -2.02008950396614 0.0412825754336072 no 3195 0.0216870521914481 4678 6251364 SGTC_3145 9085516 49.47 µM -2.02288208982474 0.0410720383719804 no 3196 0.0215426527536951 4659 25236195 SGTC_1602 st001878 87.6 µM -2.02495311381799 0.0409164638923535 no 3197 0.0214360894470295 4666 595405 YLR310C CDC25 SGTC_1556 plumbagin 1.48 µM -2.03058404022562 0.0404958866180509 no 3198 0.0211486040307382 4627 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_399 oxolinic acid 75 µM -2.04100262444471 0.0397269738657821 no 3199 0.0206252831173773 4679 4628 A DNA gyrase inhibitor. SGTC_2327 6189656 200 µM -2.04639195376509 0.0393339132432815 no 3200 0.0203589115424382 4710 5349088 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -2.04779683606081 0.0392319724135786 no 3201 0.0202899552541136 4722 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2650 prasterone 100 µM -2.0490406714902 0.0391418969929563 no 3202 0.0202290690296118 4723 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_326 k292-0812 17.5 µM -2.05299998891968 0.0388562934558785 no 3203 0.0200362892909047 4698 3579357 SGTC_2389 9091542 195.52 µM -2.06251015473319 0.0381772128156483 no 3204 0.0195795958863565 4680 3626624 YOL127W RPL25 SGTC_1578 josamycin 24.2 µM -2.07038362280799 0.0376223532762539 no 3205 0.0192082171271441 4700 5282165 A P450 substrate. SGTC_1321 1326-2144 215 µM -2.07250256764193 0.037474156487931 no 3206 0.0191092985203883 4685 3513030 SGTC_2565 isoliquiritigenin 100 µM -2.07870135479791 0.0370433551663359 no 3207 0.0188224041948087 4660 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1404 3909-7820 48.3 µM -2.08000863415377 0.036953021121685 no 3208 0.0187623704669087 4692 23741373 SGTC_1795 st049545 62.3 µM -2.08131162037835 0.0368631630185113 no 3209 0.0187026961082645 4684 5291882 SGTC_2231 micatex 6.853 µM -2.08369955535297 0.036698947154144 no 3210 0.0185937523530397 4711 20737 An antifungal of unknown mechanism. SGTC_2012 4023501 200 µM -2.08549913267435 0.0365755878203498 no 3211 0.0185120084030693 4681 3477460 SGTC_1222 0366-0074 1.18 µM -2.08553631163809 0.0365730428184891 no 3212 0.0185103228183928 4715 286520 SGTC_2226 7298446 200 µM -2.09309255004647 0.0360587966525067 no 3213 0.0181704468141775 4713 3283010 SGTC_173 1273-0061 2.693 µM -2.10097496859301 0.0355286781186549 no 3214 0.017821581814639 4659 2847414 YPL266W DIM1 SGTC_2076 5212012 200 µM -2.10631228266969 0.0351733671209822 no 3215 0.0175886175423078 4704 604802 SGTC_1 0258-0098 57.368 µM -2.10720542241018 0.0351141955078112 no 3216 0.0175498885605403 4629 6790032 YDR047W HEM12 SGTC_1522 st012842 45.6 µM -2.11581991362135 0.0345476576098146 no 3217 0.0171800633922933 4568 3491067 YOR116C RPO31 SGTC_487 nimodipine 119 µM -2.11665423183278 0.0344931892086396 no 3218 0.0171446019216971 4734 4497 L-type voltage-gated calcium channels inhibitor SGTC_2170 morpholine 200 µM -2.12611947808733 0.0338801777677822 no 3219 0.0167466562393019 4720 121171 Reacts with secondary amines. SGTC_1955 wogonin 32.4 µM -2.12822256925854 0.033745196161923 no 3220 0.016659317216277 4676 5281703 A flavanone. SGTC_3209 9113616 49.47 µM -2.14290306095788 0.0328152428348658 no 3221 0.0160604415740155 4698 16649353 SGTC_1855 st056195 39.6 µM -2.1471425775639 0.0325506515632021 no 3222 0.0158909662644728 4666 4028379 SGTC_751 0833-0568 350 µM -2.15346814468358 0.0321591420143926 no 3223 0.0156409525165296 4720 6954252 SGTC_2648 atorvastatin 78.68 µM -2.15433405148438 0.0321058520163115 no 3224 0.0156069921588836 4730 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1547 harmine 94.2 µM -2.15588916583887 0.0320103295631907 no 3225 0.0155461603288108 4644 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2761 levamisole 97.89 µM -2.15767809678393 0.0319007353804446 no 3226 0.0154764340258411 4710 26879 An alkaline phosphatase inhibitor. SGTC_959 1222-0044 107 µM -2.15877342443105 0.0318337860903599 no 3227 0.015433874604383 4717 6083612 SGTC_989 1501-0895 10.3 µM -2.16794116603905 0.0312779688404343 no 3228 0.0150815816044962 4717 2830112 SGTC_2700 st077718 96.8 µM -2.17087099818105 0.0311020418773773 no 3229 0.0149704625900856 4692 904970 SGTC_3112 9123419 49.47 µM -2.17231766416152 0.0310154766311035 no 3230 0.0149158552839758 4738 17015854 SGTC_3222 9128301 49.47 µM -2.17411583961073 0.030908155858496 no 3231 0.0148482183473577 4667 4911358 SGTC_152 4469-0003 551.229 µM -2.17556604549369 0.0308218270634335 no 3232 0.0147938622907477 4702 697280 SGTC_1938 st074717 56.4 µM -2.18826339714462 0.0300744632092921 no 3233 0.0143252107431468 4643 17250979 SGTC_3043 9092303 49.47 µM -2.20149945671427 0.0293114495146923 no 3234 0.013850342556586 4711 25236084 SGTC_2930 9013230 14.89 µM -2.20366263685897 0.0291882911582293 no 3235 0.0137740393250053 4691 2995857 SGTC_2974 9094440 9.66 µM -2.21822094598416 0.028370564924946 no 3236 0.0132698856237278 4690 25236134 SGTC_2698 st077697 67.5 µM -2.22104474779615 0.0282141828444354 no 3237 0.0131739653657521 4695 3154499 SGTC_1656 st012921 11 µM -2.22265771491789 0.0281251792081262 no 3238 0.0131194446278631 4657 6732821 SGTC_2119 5528445 120.635 µM -2.22506874199865 0.0279925745339656 no 3239 0.013038311877762 4731 791935 SGTC_2411 st077133 39.94 µM -2.2274855221283 0.0278601764140279 no 3240 0.0129574211742984 4685 1403142 YNL221C POP1 SGTC_2073 5212005 126 µM -2.23456193044513 0.0274755074069139 no 3241 0.0127230612456729 4706 691789 SGTC_894 0960-0238 55.9 µM -2.244064050186 0.02696595303812 no 3242 0.0124141402957404 4732 6741907 YDL195W SEC31 SGTC_574 1315-0397 40 µM -2.25293754244108 0.026497255299417 no 3243 0.0121315436586136 4726 6794277 SGTC_156 3474-0145 5.642 µM -2.2669464784719 0.0257711706028049 no 3244 0.0116967477263105 4683 2265471 SGTC_3083 9117465 49.47 µM -2.26870699490811 0.0256811118698008 no 3245 0.011643074976378 4705 16420915 SGTC_2657 nystatin 74.44 µM -2.27464585562731 0.025379252174398 no 3246 0.0114635914755525 4740 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1853 st056710 91.2 µM -2.27481619502055 0.0253706382180455 no 3247 0.0114584791534168 4748 269167 SGTC_1406 3909-7906 11.9 µM -2.28184074032369 0.0250175384544019 no 3248 0.0112493722655741 4745 X1406 SGTC_62 0180-0423 3.232 µM -2.28184395578393 0.025017377772497 no 3249 0.0112492773122927 4704 30102 YGL099W LSG1 SGTC_2927 9011802 47.9 µM -2.28215662403607 0.0250017573509736 no 3250 0.0112400474737703 4699 43912568 SGTC_2858 9025781 8.96 µM -2.28692780127846 0.0247644093470258 no 3251 0.011100018793217 4569 4894980 YPL153C RAD53 SGTC_1763 st044482 94.5 µM -2.28701319365968 0.024760178675579 no 3252 0.0110975265048188 4732 88505 SGTC_1007 4101-0031 70 µM -2.2925360747944 0.0244878383884288 no 3253 0.010937364173855 4723 1146276 SGTC_617 3770-0098 35 µM -2.29306601163674 0.0244618392401601 no 3254 0.0109221024033951 4702 5962639 SGTC_1786 berberine 21.6 µM -2.30626739263895 0.0238216083762109 no 3255 0.0105478479730706 4656 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1489 4065-0444 182 µM -2.30644080145724 0.0238132931628922 no 3256 0.0105430071789588 4743 2877968 SGTC_3066 9117245 49.47 µM -2.30851239063909 0.0237141458964512 no 3257 0.0104853272401666 4753 17176980 SGTC_503 tyrphostin 8 294 µM -2.32304441848587 0.0230283491095542 no 3258 0.0100883831835865 4744 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2328 6201408 200 µM -2.33177566081256 0.0226243929667083 no 3259 0.0098562480453774 4702 2890418 SGTC_1204 4049-0315 18.3 µM -2.33698655213478 0.0223861664735925 no 3260 0.00971994166827959 4719 588402 SGTC_49 0717-0965 32.132 µM -2.34070452142009 0.0222174882655634 no 3261 0.00962369660067274 4755 5889349 YGL099W LSG1 SGTC_3108 9121785 49.47 µM -2.34601925707669 0.0219782305194483 no 3262 0.00948756353451836 4659 17140271 SGTC_1079 idarubicin 2.36 µM -2.34875709701543 0.0218558302731813 no 3263 0.00941809514697992 4765 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1688 st021091 57.6 µM -2.36132748113163 0.0213012121761262 no 3264 0.00910482115979829 4775 3656366 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -2.3744425714134 0.0207352945823289 no 3265 0.00878773500754719 4727 17037758 SGTC_1692 fluoroquinolonic acid 71 µM -2.37555282612374 0.0206879769915727 no 3266 0.00876134199213779 4761 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_3123 9126162 49.47 µM -2.38479271071365 0.0202977212107698 no 3267 0.00854437363292349 4736 25239884 SGTC_1713 st033146 12.748 µM -2.4139539099378 0.0191067531111087 no 3268 0.00789022919888866 4727 674619 SGTC_2108 5365811 200 µM -2.41786080755727 0.018951797648306 no 3269 0.00780602378222127 4757 780283 SGTC_444 curcumin 90.4 µM -2.41808711649364 0.0189428546240356 no 3270 0.00780117045993706 4677 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_97 0535-0701 19.132 µM -2.42849277147825 0.0185355148409836 no 3271 0.00758086367366916 4692 2832013 YGL099W LSG1 SGTC_1330 1469-0054 61.8 µM -2.432585305518 0.0183773644644227 no 3272 0.00749572984190982 4733 7102664 SGTC_1450 4112-4260 37.6 µM -2.43266714654186 0.0183742135891839 no 3273 0.0074940359904228 4742 1633175 SGTC_2677 mitomycin C 100 µM -2.43549347449456 0.0182656821146111 no 3274 0.00743574641711919 4789 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2246 7293507 91.5585 µM -2.43850302696274 0.0181507157490825 no 3275 0.00737411758846405 4751 887656 SGTC_1295 1013-0063 9.78 µM -2.44929172795941 0.0177436370101996 no 3276 0.00715687317508277 4770 6826038 SGTC_1009 4106-0057 9.87 µM -2.46094028537516 0.0173128852884056 no 3277 0.00692867140087122 4750 2928005 SGTC_2942 9052777 62.25 µM -2.47552998286756 0.0167860005070618 no 3278 0.00665192952992396 4748 6469503 SGTC_1293 1000-1278 195 µM -2.4884730597027 0.0163301216614315 no 3279 0.00641464783368762 4754 678847 SGTC_2838 9002687 71.43 µM -2.49348496238414 0.0161564630515965 no 3280 0.00632479711639115 4732 6457060 SGTC_669 0108-0021 26.2 µM -2.52858440180044 0.0149840720024949 no 3281 0.00572617734961316 4737 17201 SGTC_1187 1391-0724 117 µM -2.53231395192717 0.0148639064711642 no 3282 0.0056656242308542 4778 6997986 SGTC_1596 piperlongumine 63 µM -2.56983508500652 0.0137003811171814 no 3283 0.00508734692538584 4776 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_824 1304-0008 100 µM -2.57325782223432 0.013598263476308 no 3284 0.00503730633449108 4766 768245 SGTC_2350 9023895 38.85 µM -2.60713955198958 0.0126223344469639 no 3285 0.00456510705527057 4745 2997209 SGTC_37 0566-0070 1.56 µM -2.6259637635392 0.012106778132983 no 3286 0.00432020076162942 4737 1626686 SGTC_1225 1216-0074 20.6 µM -2.62905475355253 0.012023890948721 no 3287 0.00428112868432577 4771 4241466 SGTC_2621 lithochol-11-enic acid 100 µM -2.64619167288376 0.0115732219560906 no 3288 0.00407018384158198 4738 6708711 SGTC_2065 5221596 34.26 µM -2.64789155376781 0.0115293283498525 no 3289 0.00404977514734675 4754 788581 SGTC_2804 7954240 19.48 µM -2.66766360863193 0.0110293091532548 no 3290 0.00381903452124992 4754 828705 SGTC_2124 5246320 200 µM -2.6723023248144 0.0109147692006675 no 3291 0.0037666372055707 4779 579342 SGTC_1112 tnp00069 1.16933 µM -2.6767393559775 0.0108061792707383 no 3292 0.00371712216733822 4765 145826 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -2.67807426313841 0.0107736939183229 no 3293 0.00370233994391355 4779 688803 SGTC_1407 3909-7909 12.3 µM -2.68398944017169 0.0106307673406499 no 3294 0.00363747020134514 4780 4411780 SGTC_2612 dictamnine 15.46 µM -2.6899858814911 0.0104875657264123 no 3295 0.00357275210234513 4737 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1427 4048-4900 550 nM -2.69373988467114 0.0103987740949155 no 3296 0.00353276406639822 4782 24132586 SGTC_842 0271-0008 11.1 µM -2.70133411890395 0.0102211530318112 no 3297 0.00345309605070585 4782 1221709 SGTC_2841 9004761 38.96 µM -2.77155171105815 0.00870031272189497 no 3298 0.00278949050878327 4740 2991039 SGTC_356 1634-0012 32.5 µM -2.7819470458769 0.00849291338854104 no 3299 0.00270169278857872 4784 735457 SGTC_193 1273-0060 1.558 µM -2.78408388425703 0.0084508225639838 no 3300 0.00268395747385778 4738 2847393 YHR072W ERG7 SGTC_1322 1348-1070 12 µM -2.79418400151163 0.00825434173230593 no 3301 0.00260154321071676 4779 6758089 SGTC_2337 9009472 200 µM -2.80373457072076 0.00807225390964193 no 3302 0.0025257236032972 4743 5742383 SGTC_1680 diphenhydramine 100 µM -2.85154123429639 0.00721286109259089 no 3303 0.00217539214530142 4756 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2118 5526350 200 µM -2.85752486684861 0.00711119092750071 no 3304 0.00213479589216007 4787 743594 SGTC_1430 4049-0248 69.1 µM -2.8589112477959 0.00708781560510884 no 3305 0.00212548850125893 4792 22774488 SGTC_1989 st071868 50.2 µM -2.88794771085339 0.0066135785409927 no 3306 0.00193882163859103 4790 16414057 SGTC_2638 epoxomicin 18 µM -2.93710839942782 0.00587436767580402 no 3307 0.00165644140686585 4775 9915668 A protesome inhibitor. SGTC_3266 9136860 49.47 µM -2.93759230533008 0.00586747116460516 no 3308 0.00165385844056914 4632 4871271 YPR165W RHO1 SGTC_1021 4476-0760 85.3 µM -2.95451024890536 0.00563083129295814 no 3309 0.00156582875727655 4789 746768 SGTC_1922 5578187 25 µM -2.98764324414409 0.00519180567305509 no 3310 0.00140568757180228 4784 1350412 SGTC_1374 2889-5571 141 µM -2.9895515079419 0.00516747422604535 no 3311 0.00139693668859304 4787 2853281 SGTC_3286 9117135 37.221 µM -2.99701280375829 0.00507330974457506 no 3312 0.00136319631067196 4764 3438150 SGTC_2893 9048488 25.97 µM -3.00809769556381 0.00493623430317755 no 3313 0.00131444306120659 4782 6467338 SGTC_1908 st060353 56.5 µM -3.00951214555086 0.00491898279409266 no 3314 0.00130833808234005 4777 4227716 SGTC_3037 9091026 49.47 µM -3.04983362372322 0.00444925839930657 no 3315 0.00114484084590417 4736 25236398 YIL048W NEO1 SGTC_1718 roemerine 11.9335 µM -3.06033860263688 0.00433365366608175 no 3316 0.00110543442337477 4568 235224 An aporphine alkaloid with mutagenic activity. SGTC_95 0471-0001 561.058 µM -3.06172193052617 0.00431863224427724 no 3317 0.00110033893061292 4787 4015405 SGTC_1889 st059080 5.18 µM -3.1258072733476 0.00367177655865809 no 3318 0.000886588585887992 4785 176925 Isolated from Daphnopsis sellowiana. SGTC_1228 0124-0032 52.5 µM -3.14431619835851 0.00350187664751323 no 3319 0.000832377264600233 4801 X1228 SGTC_1238 0333-0287 48.8 µM -3.16826331193483 0.00329254667819029 no 3320 0.000766762800313967 4800 7226 SGTC_1359 1582-0056 520 nM -3.17007668189751 0.00327716330245616 no 3321 0.000761993566231945 4800 3661189 SGTC_2874 9043904 71.43 µM -3.20051971679995 0.00302837893774486 no 3322 0.00068589991703848 4759 4463428 SGTC_3152 9099253 49.47 µM -3.23430143585772 0.0027723320012988 no 3323 0.000609703400445647 4703 25236131 SGTC_2288 7946289 167.31 µM -3.30316380065754 0.00230997140683917 no 3324 0.000478002637681571 4793 1246052 SGTC_735 3076-0345 636 µM -3.38179392806688 0.00186822546846765 no 3325 0.000360070724866344 4804 2888990 SGTC_3005 9076496 71.4286 µM -3.38757141456805 0.00183901315417124 no 3326 0.00035257178528011 4801 21368410 SGTC_1859 st055998 20 µM -3.39171130367067 0.00181833699945344 no 3327 0.000347287914319945 4786 676301 SGTC_2092 5303694 80.6725 µM -3.42507669651378 0.00165926094658335 no 3328 0.000307312943062389 4803 1963699 SGTC_310 1273-0058 1.06 µM -3.47453999492061 0.00144666997127547 no 3329 0.000255865035798913 4570 2734232 SGTC_2821 7996764 71.43 µM -3.49008608878449 0.00138517895182416 no 3330 0.000241432484907627 4785 2987135 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -3.49298923379435 0.00137396391237165 no 3331 0.000238822882981028 4806 5393153 SGTC_2969 9091408 28.7 µM -3.57522428102931 0.00108876877378297 no 3332 0.000174963892861174 4789 4286311 SGTC_3000 9075062 71.4286 µM -3.60231991532328 0.0010074112436919 no 3333 0.000157694942159699 4801 17057871 SGTC_618 k072-0232 33.2 µM -3.61360232910797 0.000975210494420282 yes 3334 0.000150986049126711 4804 5872756 YGL099W LSG1 SGTC_2575 plumbagin 510 nM -3.69775656058405 0.000763267952021775 yes 3335 0.000108756667607793 4792 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2896 9052656 71.43 µM -3.72023140036391 0.000714332582178129 yes 3336 9.95201633584915e-05 4596 6469436 SGTC_111 0083-0039 52.457 µM -3.81342493764916 0.00054072590141514 yes 3337 6.85270822426407e-05 4807 759313 SGTC_1327 1436-0082 2.18 µM -3.88432028575983 0.00043577108918506 yes 3338 5.13082810146576e-05 4809 15992205 SGTC_2223 6903751 107.57 µM -3.92598857577534 0.000383246101857437 yes 3339 4.31871275375095e-05 4803 5598863 SGTC_928 2764-0428 58.7 µM -3.9397553413794 0.000367227084896208 yes 3340 4.07823738872973e-05 4806 662578 SGTC_726 3448-4391 34.2 µM -4.112753694153 0.000212370458635904 yes 3341 1.95483726034085e-05 4806 1356692 SGTC_2564 betulinic acid 100 µM -4.16894444297626 0.000176977059778952 yes 3342 1.5300678167171e-05 4794 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_479 n-linoleoylglycine 10 µM -4.20964949711296 0.000154870831878314 yes 3343 1.27883580220773e-05 4807 6433346 An anti-infammatory. SGTC_2421 5690543 90.72 µM -4.22334885195005 0.000148032010488707 yes 3344 1.2034940674632e-05 4764 3397993 SGTC_720 r052-1644 49.9 µM -4.22499934900527 0.000147227435164043 yes 3345 1.19470734372506e-05 4804 1422863 YOR257W CDC31 SGTC_568 1193-0097 7.48 µM -4.29806469603673 0.00011544908465429 yes 3346 8.61479391472718e-06 4772 3646150 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -4.30418779190264 0.0001131014713449 yes 3347 8.37997287100055e-06 4803 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2880 9042983 58.44 µM -4.68942671470822 2.94728365572262e-05 yes 3348 1.36985765837065e-06 4799 6464714 SGTC_831 k061-1017 217 µM -4.7079526386711 2.7555399241386e-05 yes 3349 1.2510860812583e-06 4809 1240153 SGTC_2116 5511452 16.8835 µM -5.04482864919003 7.77710487295839e-06 yes 3350 2.26963988518692e-07 4810 870744 SGTC_475 α-linolenic acid 10 µM -5.10471729132148 6.15945816111564e-06 yes 3351 1.65644705071135e-07 4810 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2871 9038510 12.99 µM -5.10657730529659 6.11476319176932e-06 yes 3352 1.64023219947711e-07 4809 4945164 SGTC_2408 sulbentine 18.36 µM -5.25620245876322 3.37674982392214e-06 yes 3353 7.3530196594646e-08 4798 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2113 5491891 107.031 µM -5.29684601178877 2.86596676461915e-06 yes 3354 5.89099853757978e-08 4808 789979 SGTC_2904 7225135 42.03 µM -5.30923798286926 2.72554931208978e-06 yes 3355 5.50422579257649e-08 4798 4446116 SGTC_2225 6654152 15.4 µM -5.986869653302 1.48231323190712e-07 yes 3356 1.06959039431703e-09 4810 97582 YGR029W | YLR033W ERV1 | RSC58