SGTCid condition conc unit YNL143C|YNL143C.score YNL143C|YNL143C.strain.pval YNL143C|YNL143C.strain.significant YNL143C|YNL143C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2869 9037858 32.47 µM 5.64538515066703 8.74594450006757e-08 yes 1 8.24059319349419e-09 3 27187042
SGTC_52 0329-0193 875 nM 5.36856735211336 3.38310221189195e-07 yes 2 3.96822763295197e-08 12 3739292
SGTC_47 0149-0135 24.25 µM 4.88520886480948 3.08408843074394e-06 yes 3 5.16596345082428e-07 8 5239155
SGTC_2390 9097792 176.6 µM 4.76902040327162 5.09757697613937e-06 yes 4 9.25619560773361e-07 4 4497149
SGTC_2019 4016004 108 µM 4.50569006888101 1.52806141682231e-05 yes 5 3.30787952684818e-06 13 45595336
SGTC_2513 baicalein 25.65 µM 4.46660864898351 1.78976194070588e-05 yes 6 3.97346555945118e-06 18 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2878 9043973 25.97 µM 4.36981463978772 2.63327361659908e-05 yes 7 6.21760232343666e-06 9 6465167
SGTC_2020 4017018 200 µM 4.15638220451667 6.00528200681307e-05 yes 8 1.61663377816023e-05 13 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1696 st025591 34.7925 µM 4.0966125296272 7.51463672550139e-05 yes 9 2.09619870628715e-05 23 2787147
SGTC_3304 9125678 46.087 µM 4.00763450773692 0.000104359121589675 yes 10 3.0664966818152e-05 44 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2867 9039098 71.43 µM 3.99439836563463 0.000109523645693151 yes 11 3.24293676516465e-05 31 6463460
SGTC_1180 1193-0155 285 µM 3.68316492851709 0.000327346164258118 yes 12 0.000115178006592537 19 2921347
SGTC_2319 6033012 152.6 µM 3.65002492472454 0.000366130711383533 yes 13 0.000131107431800345 37 847246
SGTC_2810 7959871 45.46 µM 3.60848111361039 0.000420778936970672 yes 14 0.000153997465603899 50 2974535
SGTC_2895 9054447 58.44 µM 3.57208383988462 0.000474778945657741 yes 15 0.000177075993874407 15 2697450
SGTC_3220 9131269 49.47 µM 3.48590201755852 0.000629231025789886 yes 16 0.000245240310757803 20 17722206
SGTC_2860 9025725 38.96 µM 3.4489077286953 0.000708798042089326 yes 17 0.000281429500948502 21 40546248
SGTC_1842 st055362 61.2 µM 3.4106770708207 0.000800687032227011 yes 18 0.000324008957700084 26 676032
SGTC_402 epigallocatechin gallate 10 µM 3.38437803224186 0.00087013306983097 yes 19 0.000356698532192184 58 65064 An antioxidant.
SGTC_1715 st032160 10.2275 µM 3.34744628460215 0.000977029192685892 yes 20 0.000407798961014939 65 5289825
SGTC_3110 9122132 49.47 µM 3.33078591594858 0.0010290901793186 no 21 0.000433005885171298 32 918317
SGTC_385 1494-0393 12.4 µM 3.27277453116232 0.00123085647881626 no 22 0.000532486969035507 57 3090647
SGTC_2498 4'-Methoxychalcone 54.63 µM 3.26408865216239 0.00126400552729409 no 23 0.000549083990541631 58 641818 YHR062C RPP1
SGTC_2050 5263056 171 µM 3.2255283387819 0.00142125400554884 no 24 0.000628701933973256 81 763468 YGL055W OLE1
SGTC_3300 9124615 50.48 µM 3.2197236955995 0.00144641456531281 no 25 0.000641571030825747 45 24824903
SGTC_821 1114-0266 29.2 µM 3.18794050219849 0.00159153239504935 no 26 0.000716450086822593 52 3123235
SGTC_1849 st056239 19.2 µM 3.17213568056785 0.00166852841797266 no 27 0.000756611453913326 66 5393181
SGTC_3202 9113761 49.47 µM 3.10683296103168 0.00202393942286623 no 28 0.000945516091217841 93 4798415
SGTC_2318 6029776 164 µM 3.10487824630374 0.00203556590858992 no 29 0.000951786821814642 68 818325
SGTC_2922 7999257 32.47 µM 3.10325131558483 0.00204528894859776 no 30 0.000957035119959721 32 2988377
SGTC_1134 3477-0009 42.5 µM 3.08999915564248 0.00212607149357228 no 31 0.00100078532168716 88 3973534
SGTC_2627 acetyl isogambogic acid 100 µM 3.0351362104642 0.00249219446714277 no 32 0.00120213538601797 91 6857789 A caspase activator and apoptosis inducer.
SGTC_1768 st044301 37.178 µM 3.03412829089219 0.00249942416810812 no 33 0.00120615911476453 56 3931349
SGTC_294 k038-0071 157 µM 2.98633550560354 0.00286478708976115 no 34 0.00141171345397879 117 24152826
SGTC_1292 0kpi-0043 232 µM 2.91083560706528 0.00354078967574061 no 35 0.00180231808818213 57 3333905
SGTC_750 4073-0104 132 µM 2.82854792613031 0.00443772558579037 no 36 0.0023379849597558 50 22330957
SGTC_1197 1601-0112 267 µM 2.79167254919152 0.0049017906903799 no 37 0.00262181956831045 87 7350313
SGTC_2053 5265679 138 µM 2.7825149725275 0.0050235395462016 no 38 0.00269696882051808 98 764595
SGTC_664 1222-0054 14.9 µM 2.77251560564678 0.00515954913104466 no 39 0.00278124261090891 99 6813991
SGTC_2059 5238311 157 µM 2.76829599732959 0.00521792004421586 no 40 0.00281751257101461 88 703021
SGTC_1199 1638-0010 4.46 µM 2.7549696100561 0.00540614412109476 no 41 0.00293487936047568 89 3111136
SGTC_1140 3229-1848 2.98 µM 2.73037682998604 0.00576939936788563 no 42 0.00316309838644737 50 2849525
SGTC_1357 1503-1303 39.5 µM 2.69840708053184 0.00627391521087865 no 43 0.00348360925387268 124 292895
SGTC_2681 menadione 3.18 µM 2.69002627683871 0.00641247387400612 no 44 0.00357231965307997 84 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_393 acivicin 6.25 µM 2.67507808366098 0.00666634372284136 no 45 0.00373559234624141 69 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1839 st053978 48 µM 2.66867462233439 0.00677778650613742 no 46 0.00380755910206795 90 3788398
SGTC_2454 5-benzylidenerhodanine 10.36 µM 2.66196479823949 0.00689632398166948 no 47 0.00388430012022683 130 1273210
SGTC_2007 4011539 71.82 µM 2.65163820220993 0.0070823340479052 no 48 0.00400511618530428 149 45595301
SGTC_1089 terbinafine 2.25 µM 2.64891572099489 0.00713210489742114 no 49 0.00403752330996185 89 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_912 3474-0017 2.18 µM 2.63432042571778 0.00740422420049979 no 50 0.00421529427687364 99 3360550
SGTC_917 harmaline 728.087 nM 2.61040431734527 0.00786993008795411 no 51 0.00452176334008977 110 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1215 3852-0577 11.2 µM 2.56577557420024 0.00880823470023492 no 52 0.00514727055768764 101 2884876
SGTC_578 3460-0051 92 µM 2.5627800336169 0.00887458948301966 no 53 0.00519189060338399 93 2876744
SGTC_3097 9117246 49.47 µM 2.55991001788035 0.00893857422336121 no 54 0.0052349634158402 96 16423892
SGTC_1299 1079-1439 3.74 µM 2.55638686296489 0.0090176725174565 no 55 0.00528827292707992 92 323161
SGTC_77 0828-0286 12.516 µM 2.55231830499117 0.00910977782450529 no 56 0.00535043534633306 149 745345
SGTC_1154 4088-0362 150 µM 2.54893133230694 0.0091870804074687 no 57 0.00540267868554696 132 6618304
SGTC_642 0335-0876 158 µM 2.53776453509556 0.00944602776330829 no 58 0.00557815088866815 126 6812350
SGTC_2580 diallyl disulphide 81.36 µM 2.527219660057 0.0096963901938184 no 59 0.00574847849493549 110 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1028 k015-0029 4.8 µM 2.52600588741949 0.00972557710362111 no 60 0.0057683773941309 139 4588309
SGTC_3057 9095946 49.47 µM 2.52325342515986 0.00979204855900227 no 61 0.00581372860467674 76 24540043
SGTC_163 TUB2.036 7.546 µM 2.51308820322518 0.0100409878780377 no 62 0.00598397042474532 275 15992207 YJR013W GPI14
SGTC_2456 5770359 74.46 µM 2.49163798040303 0.0105844751116335 no 63 0.00635777836209138 105 3118787
SGTC_2561 acetosyringone 100 µM 2.47708606477095 0.0109676101680798 no 64 0.00662299783771061 146 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3093 9117344 49.47 µM 2.45899289449882 0.0114607661565301 no 65 0.00696636876581707 117 24824913
SGTC_2489 cantharidin 73.42 µM 2.45516100428417 0.0115676473878566 no 66 0.00704107506911286 174 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2614 arthonioic acid 13.39 µM 2.43698101231684 0.0120866101469016 no 67 0.00740522851297274 114 6710684
SGTC_264 promethazine 12.5 mM 2.43236590910041 0.0122215212281817 no 68 0.00750027232094539 204 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1195 1502-0147 41.1 µM 2.42070391820948 0.012568259962874 no 69 0.00774524422166317 141 817940
SGTC_1372 2752-0194 270 µM 2.41793126347759 0.01265193971871 no 70 0.00780451253071596 107 823334
SGTC_1630 st005209 31.3 µM 2.39849865628367 0.0132520683030293 no 71 0.00823121844569963 158 3367314
SGTC_298 1391-0729 10 µM 2.39680980599122 0.0133053672078723 no 72 0.00826925289848392 105 3237558
SGTC_1251 0490-5699 265 µM 2.37369485436914 0.0140536765620339 no 73 0.00880554901478591 161 3883818
SGTC_818 4072-2707 53.5 µM 2.36264041493665 0.0144241866073901 no 74 0.00907263304855693 110 882871
SGTC_2782 7736369 71.43 µM 2.34718134982418 0.014956411295917 no 75 0.00945802271617393 185 2950836 YOL077C BRX1
SGTC_1243 0416-0003 5.65 µM 2.33880401981543 0.0152518164635907 no 76 0.00967278929585823 168 2141977
SGTC_208 k072-0098 12.366 µM 2.32825041110252 0.0156310844313966 no 77 0.00994940538977081 211 5948901
SGTC_55 0767-0285 6.563 µM 2.31927021831749 0.0159601531590045 no 78 0.010190194594158 174 3116166
SGTC_2099 5377090 177.372 µM 2.29337209362811 0.0169426127492535 no 79 0.0109132959245461 167 2243829
SGTC_2091 4-phenylthiadiazole 200 µM 2.26771345835541 0.0179665256947754 no 80 0.0116733385159755 160 270010
SGTC_2088 5278280 127.392 µM 2.25996317202708 0.0182859951567167 no 81 0.0119117683092675 190 791502
SGTC_407 eburnamonine 100 µM 2.25908748132909 0.0183223939140569 no 82 0.0119389718514229 142 3195
SGTC_1337 1486-1011 40.3 µM 2.25749988197551 0.0183885411039346 no 83 0.0119884284275599 134 X1337
SGTC_1415 3966-0071 78.1 µM 2.25297371734396 0.0185782409971209 no 84 0.0121304030950211 115 2893185
SGTC_1250 0485-0349 40.2 µM 2.2520131671866 0.0186187130303073 no 85 0.0121607199694874 184 6842794 YDL195W SEC31
SGTC_40 0327-0103 19.753 µM 2.24360858184191 0.0189760458650781 no 86 0.0124287983067465 185 409036
SGTC_944 3370-0224 231 µM 2.24333867972811 0.0189876171377071 no 87 0.0124374914437554 169 4580514
SGTC_610 4215-0184 155 µM 2.23850323473124 0.0191959418704152 no 88 0.0125941283545398 162 5605015
SGTC_2104 5389443 200 µM 2.22576169180157 0.0197542095735272 no 89 0.0130150740219669 181 2244536
SGTC_1294 1000-1494 117 µM 2.22531531609413 0.0197740147136532 no 90 0.0130300389850454 166 712797 YDL207W GLE1
SGTC_2406 ethylparaben 405.7 µM 2.2080155142029 0.0205546745923636 no 91 0.0136215958504126 184 8434 A possible steroid mimic.
SGTC_679 0422-0091 41.4 µM 2.19939126045248 0.0209535011113596 no 92 0.01392505676638 207 627384 YHR062C RPP1
SGTC_1616 st002734 56.1 µM 2.19804416710137 0.0210163847310673 no 93 0.0139729793295673 196 4026101
SGTC_2384 9036245 200 µM 2.19196679296634 0.0213020714520678 no 94 0.0141909522440998 159 6462766
SGTC_746 1095-0025 46.6 µM 2.18326012414729 0.0217170744761145 no 95 0.014508329657399 165 6749286
SGTC_1131 3454-3128 32.3 µM 2.17802468931156 0.0219698944113732 no 96 0.014702099346749 227 710982
SGTC_1436 4092-1007 8.32 µM 2.17339110015317 0.0221957196654521 no 97 0.0148754470509441 158 2881121
SGTC_905 2-aminofluorene 215 µM 2.15918941168958 0.0229000981150581 no 98 0.0154177375887183 200 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2097 5376186 200 µM 2.14563190921341 0.0235900032268729 no 99 0.0159511787757107 196 742755
SGTC_2818 7996756 12.99 µM 2.14301104142543 0.0237253689693399 no 100 0.0160561058901092 120 2241621
SGTC_2675 theaflavin digallate 100 µM 2.12922389554159 0.024448264018613 no 101 0.0166178704029979 190 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_738 1315-0003 72.4 µM 2.12140349393771 0.0248664638272483 no 102 0.0169439307463773 197 6251474
SGTC_178 4092-0806 87.505 µM 2.11797674872327 0.0250515920836803 no 103 0.0170885184462836 321 2169044
SGTC_2389 9091542 195.52 µM 2.10928224920329 0.0255264988461913 no 104 0.0174601130274797 213 3626624 YOL127W RPL25
SGTC_2532 xanthone 78.9 µM 2.10506490237807 0.0257595582974963 no 105 0.0176428294362325 190 7020 An insecticide.
SGTC_1845 st056753 3.01 µM 2.100451198568 0.0260165584216192 no 106 0.0178445846268949 227 5375839
SGTC_2896 9052656 71.43 µM 2.0927242860798 0.0264517782374708 no 107 0.0181868869992081 378 6469436
SGTC_3264 9137442 49.47 µM 2.08685176492402 0.0267866037698609 no 108 0.0184507681006935 145 17015726
SGTC_1049 3226-0134 66 µM 2.08117890284967 0.0271133989430245 no 109 0.0187087669275863 227 5702385
SGTC_1943 st076331 65.2 µM 2.08025760436809 0.0271667846963273 no 110 0.0187509555860057 181 24208415
SGTC_1458 k015-0034 6.33 µM 2.07933106033606 0.0272205628329714 no 111 0.0187934660783021 180 3598957
SGTC_1064 honokiol 6.76 µM 2.07272077127972 0.0276068173398486 no 112 0.0190991367705832 202 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2468 5987765 72.9 µM 2.06908761512692 0.0278210495092382 no 113 0.019268932852665 167 26772094
SGTC_19 0279-0214 38.434 µM 2.0674002260054 0.0279210178822677 no 114 0.0193482284900432 302 3566274 YBR002C RER2
SGTC_125 0133-0007 11.75 µM 2.06575024243641 0.0280190593423445 no 115 0.0194260342798187 174 26541
SGTC_1515 3460-0031 42.1 µM 2.05019245210441 0.0289576699560676 no 116 0.0201728271311931 155 2876596
SGTC_816 0325-0417 81.3 µM 2.03056612977057 0.0301788682483357 no 117 0.0211495132477307 186 68101
SGTC_613 3914-0030 117 µM 2.0211578752829 0.03077923852148 no 118 0.0216317124003295 47 1145395
SGTC_1072 oxiconazole 14.9 nM 2.01821562557155 0.0309690100721733 no 119 0.021784404743524 254 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_179 1273-0063 6.77 µM 2.01733798943485 0.0310258036742132 no 120 0.0218301268553268 182 3108139
SGTC_663 1486-0733 13.9 µM 2.01186195721397 0.0313821182796639 no 121 0.022117245300776 284 722445 YPR165W RHO1
SGTC_3053 9095903 49.47 µM 2.00956147846415 0.0315328118507337 no 122 0.022238810880018 151 17174018
SGTC_2521 angolensin 13.4 µM 2.00668848845354 0.0317218473723822 no 123 0.0223914212569103 172 821428 A flavenoid.
SGTC_1431 4049-0260 9.09 µM 2.00440936614159 0.0318724730663313 no 124 0.0225131134157832 197 3854841
SGTC_1605 st000082 49.1 µM 2.00276142318577 0.0319817521459321 no 125 0.0226014511790907 207 1114022
SGTC_161 4065-0411 162.148 µM 1.99745674045397 0.0323356213558037 no 126 0.0228877946561354 311 1906281 YLR208W SEC13
SGTC_1962 st076595 64.5 µM 1.99049090141377 0.0328052053508919 no 127 0.0232684426427337 236 279619
SGTC_3067 9117431 49.47 µM 1.97236508022022 0.0340535084683955 no 128 0.0242839725853465 183 17150885
SGTC_1159 4092-0538 61.2 µM 1.96995608533056 0.0342223157735242 no 129 0.0244217018660257 241 717301
SGTC_920 mycophenolic acid 780.421 nM 1.96650242384691 0.0344655261913801 no 130 0.0246203013081675 244 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2698 st077697 67.5 µM 1.96001836459255 0.0349259759121185 no 131 0.0249968219234047 208 3154499
SGTC_856 0433-0016 11.3 µM 1.95595879033682 0.0352168184756813 no 132 0.0252350044175261 236 3911780
SGTC_2833 9001315 45.46 µM 1.95081493284051 0.0355881937137131 no 133 0.0255395324118055 286 2989378
SGTC_2258 7960471 200 µM 1.94724401279727 0.0358478895112548 no 134 0.0257527436851164 170 2974708
SGTC_942 3253-1115 227 µM 1.94408901036392 0.0360786276458756 no 135 0.025942359136518 244 46497897
SGTC_1933 st074711 15.9 µM 1.94004954892921 0.0363758238871687 no 136 0.026186834236103 267 17250958
SGTC_11 0438-0307 1.3 µM 1.93712152705626 0.036592498100012 no 137 0.0263652448749784 203 4011476
SGTC_1987 st072290 61.9 µM 1.93028928661889 0.0371021932591547 no 138 0.0267855018720574 232 54697379
SGTC_2926 9010726 65.15 µM 1.92977366302799 0.0371408938455446 no 139 0.0268174440642247 255 2994293
SGTC_1092 toremifene 6.32 µM 1.92138578536651 0.0377750995903018 no 140 0.0273415446244521 288 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2475 5812728 15.03 µM 1.91230350945786 0.0384717468066604 no 141 0.0279186379799326 262 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1611 st001856 99.4 µM 1.91224862848258 0.0384759880137212 no 142 0.0279221557537082 235 647478
SGTC_3285 9112818 20.8695 µM 1.91145466914277 0.0385373879146948 no 143 0.0279730884674705 264 17017947 YPR165W RHO1
SGTC_1316 1272-0050 65.9 µM 1.91028541892578 0.038627955854171 no 144 0.0280482370637733 205 7340392
SGTC_233 rapamycin 362 pM 1.90794481636476 0.0388097756287859 no 145 0.0281991745094895 224 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2185 6113692 200 µM 1.90053742246248 0.0393897860388396 no 146 0.0286813144026003 224 874150
SGTC_3047 9092122 49.47 µM 1.89885883895927 0.0395221971051076 no 147 0.0287915192455934 247 17173831
SGTC_2813 7971799 71.43 µM 1.8987857252561 0.0395279727238387 no 148 0.0287963274044895 237 2234054
SGTC_3192 9110362 49.47 µM 1.89442532947133 0.0398736655583853 no 149 0.0290842884952796 223 16649480
SGTC_367 0335-0881 7.1 µM 1.89367482070436 0.0399334131596591 no 150 0.0291340927300797 304 23828853
SGTC_473 2-arachidonoylglycerol 10 µM 1.89266144355525 0.0400142030035584 no 151 0.0292014534820382 255 5282280 An endocannabinoid.
SGTC_1608 st001473 40.5 µM 1.89107894094938 0.0401406310557682 no 152 0.0293069036104272 271 7292267
SGTC_2401 5128683 200 µM 1.88967880629083 0.0402527599151604 no 153 0.0294004651343478 246 708373
SGTC_2607 solasodine 47.35 µM 1.88691115022868 0.040475154279595 no 154 0.0295861385642227 297 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1082 camptothecin 424.86 nM 1.88332085551443 0.0407651368886437 no 155 0.0298284493733703 262 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_354 2783-3500 4.88 µM 1.87859674895782 0.0411492617411966 no 156 0.0301497877023645 297 6740761
SGTC_1900 st060200 72.8 µM 1.86309464927975 0.0424304224065678 no 157 0.0312244754613862 242 688945
SGTC_2380 9035439 200 µM 1.85512576793798 0.0431014531483978 no 158 0.0317891344480178 295 6462575
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.85171589647602 0.0433911929144719 no 159 0.03203331505183 227 2724278 An inhibitor of dopamine biosynthesis.
SGTC_3254 9136651 49.47 µM 1.84594083618089 0.0438854899958868 no 160 0.0324503982171544 280 16454030
SGTC_1350 1495-0454 146 µM 1.84270796218412 0.0441641738863398 no 161 0.0326858304399587 305 1069057
SGTC_2168 5727979 200 µM 1.84235632545655 0.0441945719138655 no 162 0.0327115229046789 231 695210
SGTC_2033 5192550 145 µM 1.8347120904737 0.0448595736054032 no 163 0.0332741799522506 247 182073
SGTC_1094 duloxetine 25.4 µM 1.83223018519347 0.0450772085233306 no 164 0.0334585667418522 274 60834 A selective serotonin reuptake inhibitor.
SGTC_3325 9138760 55.175 µM 1.8294112488312 0.0453254270192364 no 165 0.0336690118631846 278 43844959
SGTC_2459 5811157 9.22 µM 1.82910836342573 0.0453521625643868 no 166 0.0336916881623817 262 2870684 YBR192W RIM2
SGTC_2865 9030313 51.95 µM 1.82813126618982 0.0454384969294406 no 167 0.0337649267560957 226 42562754
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.82285713559237 0.0459067932952288 no 168 0.0341625157370446 300 5377381
SGTC_3319 9138450 16.7555 µM 1.81890184569872 0.0462605266327271 no 169 0.0344632031085169 254 2029690
SGTC_2889 9059656 51.95 µM 1.81163834928804 0.0469158205560847 no 170 0.0350210476588702 273 3949838
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.80762019260873 0.0472815141775896 no 171 0.0353328166457613 251 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2893 9048488 25.97 µM 1.80707084959423 0.047331687082667 no 172 0.0353756165396823 260 6467338
SGTC_673 1082-0474 110 µM 1.80270999861198 0.0477314900557078 no 173 0.0357168855425093 375 3098046
SGTC_1847 st056231 15 µM 1.79402352127388 0.0485359228867694 no 174 0.0364047073169279 350 5393180
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.79051307482632 0.048864076629411 no 175 0.0366857336221982 382 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1925 st057770 10.1 µM 1.78424241970696 0.0494546624685797 no 176 0.0371921410657964 263 5989122
SGTC_1249 0481-0015 10.2 µM 1.78423832949474 0.0494550495461047 no 177 0.0371924732390713 257 4227577
SGTC_868 0527-0199 213 µM 1.77884113069605 0.0499679244637905 no 178 0.0376329058970394 312 2849450
SGTC_3268 9137683 49.47 µM 1.77877215582366 0.0499745062243007 no 179 0.0376385619551357 208 1953228
SGTC_794 k038-0031 316 µM 1.7777812732843 0.050069135122639 no 180 0.0377198926518307 392 6624242
SGTC_2486 5283202 22.39 µM 1.77680419686212 0.0501625853829427 no 181 0.037800230567912 300 1377751
SGTC_990 3985-0011 41.3 µM 1.77234724228495 0.0505906256860673 no 182 0.0381684668249094 252 5399565 YGL099W LSG1
SGTC_3002 9075603 71.4286 µM 1.76641867935335 0.0511645006614365 no 183 0.0386628167813001 296 20105405
SGTC_1384 3089-0840 101 µM 1.76014806652964 0.0517771099089827 no 184 0.0391913523813497 266 1069836
SGTC_1192 1488-0095 21.4 µM 1.75904992460354 0.0518849906411964 no 185 0.0392845145880535 277 915875
SGTC_655 k060-0012 42 µM 1.75776024075996 0.0520119163132409 no 186 0.0393941565076222 303 5994525
SGTC_198 3454-2873 16.191 µM 1.75511752463986 0.0522727727448122 no 187 0.0396196036658368 290 710957
SGTC_924 2046-0044 21.3 µM 1.75420254738269 0.0523633297835685 no 188 0.0396979034485343 297 3623589
SGTC_3224 9130643 49.47 µM 1.74917984207163 0.0528626571102565 no 189 0.0401299686880687 308 17644395
SGTC_3121 9125696 49.47 µM 1.74781903450159 0.0529985887360643 no 190 0.0402476841163033 228 1235365
SGTC_1857 st056007 79.3 µM 1.74592525551569 0.0531882202386989 no 191 0.0404119703449329 246 619834
SGTC_1290 0986-0249 10.2 µM 1.72408315081561 0.0554144438753463 no 192 0.042346416668946 259 53329
SGTC_148 3253-0744 288.01 µM 1.72279867611345 0.0555476187232219 no 193 0.0424624691408466 297 6893655
SGTC_172 1112-0046 2.638 µM 1.72042632104886 0.0557942495492084 no 194 0.0426774879628692 274 2802135 YIL048W NEO1
SGTC_583 1488-1091 88.9 µM 1.71809793112115 0.0560371491096291 no 195 0.042889377072291 385 4303273
SGTC_1279 0874-0590 65.2 µM 1.71727326077049 0.0561233791361579 no 196 0.0429646276326575 318 3523074
SGTC_1971 st069429 63.5 µM 1.71599915034429 0.0562568096524919 no 197 0.0430810989659426 271 1246522 YGL099W LSG1
SGTC_2822 7994718 71.43 µM 1.71587476591728 0.0562698491316446 no 198 0.0430924830771967 258 1018011
SGTC_3188 9110789 49.47 µM 1.71554185972975 0.0563047601050569 no 199 0.043122963807774 311 849217
SGTC_423 5-fluorouracil 457 µM 1.71539123883636 0.0563205609208352 no 200 0.043136760305443 336 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_662 k832-1615 104 µM 1.70150673401156 0.0577921807009303 no 201 0.0444239372010317 313 5878478
SGTC_3115 9123671 49.47 µM 1.70098250305782 0.0578483306938618 no 202 0.0444731363930552 266 3286988
SGTC_422 cantharidin 155 µM 1.69065822478688 0.0589629188471265 no 203 0.0454510486592344 395 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2413 inermin 26.06 µM 1.68655864433183 0.0594101471506146 no 204 0.0458441248489597 375 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_256 clotrimazole 625 nM 1.68458034697285 0.0596269111808137 no 205 0.0460347828664242 335 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2403 6032726 181.2 µM 1.67543644184918 0.0606368805666056 no 206 0.0469243158101834 353 2881040
SGTC_814 3342-0569 96 µM 1.67320263911287 0.0608856326434051 no 207 0.0471437055001918 366 4346283
SGTC_319 1348-1596 45.5 µM 1.67201181560719 0.0610185661693167 no 208 0.0472609960833961 341 5380505
SGTC_2397 5161689 200 µM 1.67096035938176 0.0611361304078853 no 209 0.0473647539566243 365 2259942
SGTC_1940 st075990 51.1 µM 1.67078303622705 0.0611559744975888 no 210 0.0473822702089559 378 1084979
SGTC_1325 1431-0015 227 µM 1.66925872854078 0.0613267662112959 no 211 0.0475330578318554 301 1103340
SGTC_981 1488-1094 54.9 µM 1.6688398927768 0.0613737600483803 no 212 0.0475745571729894 273 3449522
SGTC_2062 5245942 200 µM 1.668806853576 0.0613774682800885 no 213 0.0475778320178615 366 1376160
SGTC_2928 9011484 9.79 µM 1.66718156060156 0.0615601030012836 no 214 0.0477391540708313 310 2994751
SGTC_3040 9091894 49.47 µM 1.65579351172228 0.0628517108085974 no 215 0.0488818210953249 278 25236966
SGTC_2830 7992007 71.43 µM 1.65125328183776 0.0633725029563964 no 216 0.0493434337222518 317 1952075
SGTC_2556 citropten 84.59 µM 1.65076584911636 0.0634286135651374 no 217 0.0493931980026078 389 2775 A potential DNA crosslinker.
SGTC_1718 roemerine 11.9335 µM 1.65075401876576 0.0634299758913739 no 218 0.0493944063161269 405 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.64902108101522 0.0636297787818699 no 219 0.0495716579862265 311 229346 A bile salt which induces apoptosis.
SGTC_3273 9137859 49.47 µM 1.64837217344372 0.0637047219083585 no 220 0.0496381612816974 274 2377234
SGTC_181 1447-1644 8.07 µM 1.64830382787332 0.06371261921712 no 221 0.0496451698198259 347 534600
SGTC_2120 5538279 151.968 µM 1.64285960843809 0.0643441471944944 no 222 0.0502059918683677 346 2058197
SGTC_1468 k284-1086 134 µM 1.63745504533534 0.0649758758146304 no 223 0.0507677123654534 427 15996457
SGTC_854 0422-0053 192 µM 1.63472726354922 0.0652965436667444 no 224 0.0510531172669932 343 3596728
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.63342939649582 0.065449546478857 no 225 0.0511893593134925 392 5379071
SGTC_2337 9009472 200 µM 1.63082824858926 0.065757027242371 no 226 0.0514632825253101 411 5742383
SGTC_659 k018-0002 107 µM 1.62981185653601 0.0658774783886577 no 227 0.0515706335676654 361 6797879 YHR007C ERG11
SGTC_765 1319-0117 244 µM 1.62640332255591 0.0662826673027138 no 228 0.0519319422484176 327 3487746 YGL099W LSG1
SGTC_113 0099-0221 2.5 µM 1.62604574161779 0.0663252862927524 no 229 0.0519699625434902 330 89219
SGTC_3184 9108758 49.47 µM 1.62451192463899 0.0665083380702587 no 230 0.0521332987429551 299 902885
SGTC_752 1896-0090 130 µM 1.62072200019453 0.0669623196350955 no 231 0.0525386365873518 350 772567
SGTC_1076 itraconazole 331 nM 1.61930382753282 0.0671328124566999 no 232 0.0526909537809223 353 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.61607289005015 0.067522489369121 no 233 0.0530392773950851 339 689007
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.61481777241461 0.0676743371261386 no 234 0.0531750816224552 485 6708739 YPR165W RHO1
SGTC_1257 0669-0121 16 µM 1.61061855233489 0.0681842891541657 no 235 0.0536314438254732 423 4307855
SGTC_2235 salicylic acid 500 µM 1.60827778249058 0.0684698362024655 no 236 0.0538871771692174 293 338 A COX inhibitor and kinase inhibitor.
SGTC_1926 methyl fluorone black 53.6 µM 1.60227080930108 0.069206839297178 no 237 0.0545478688759725 357 72721 Reacts with homocysteine.
SGTC_721 1187-1332 279 µM 1.59128120289563 0.0705709681295024 no 238 0.0557731525797087 260 25730
SGTC_1038 k292-0204 154 µM 1.59114556761902 0.0705879325863745 no 239 0.0557884097708616 358 4454212
SGTC_3111 9122088 49.47 µM 1.5861028818506 0.0712208688902696 no 240 0.0563579866268368 247 16876704
SGTC_3007 9078383 71.4286 µM 1.58539288104924 0.0713103339898377 no 241 0.0564385488162577 375 6496995
SGTC_1936 st074407 74.3 µM 1.58060360685533 0.0719160714446008 no 242 0.0569843503069369 433 809813
SGTC_3023 9089636 49.47 µM 1.57507594165126 0.0726200951794594 no 243 0.0576194582582788 365 17249241
SGTC_1656 st012921 11 µM 1.57383691868813 0.0727786234892526 no 244 0.0577625782599964 339 6732821
SGTC_1137 ixabepilone 100 µM 1.57289703169297 0.0728990551135551 no 245 0.0578713312704503 417 154225 A novel microtubule stabilizer.
SGTC_449 xestospongin c 11.1929 µM 1.57232190435682 0.0729728237679814 no 246 0.0579379577898903 405 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_45 0kpi-0036 14.9 µM 1.57133677944014 0.0730993134577164 no 247 0.0580522211817536 354 2795021
SGTC_2734 clemastine 41.6 µM 1.56592941725914 0.0737966067917287 no 248 0.0586825710543228 211 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1147 3809-1045 12.3 µM 1.56393898997768 0.0740545537145084 no 249 0.0589159484306234 400 325925
SGTC_2635 hydroquinidine 100 µM 1.55418193245079 0.07532898116017 no 250 0.0600705129726113 389 442912 An experimental heart treatment.
SGTC_2477 5967686 25.23 µM 1.55373382570288 0.0753879100999017 no 251 0.0601239605020394 404 776118
SGTC_3324 9138759 60.749 µM 1.55172719931759 0.0756522254980037 no 252 0.0603637558534038 374 45595710
SGTC_1848 st056003 16.4 µM 1.54945422650733 0.0759524765141384 no 253 0.0606362834419488 389 146492
SGTC_1524 corynanthine 62.1 µM 1.54297205302893 0.0768137305261764 no 254 0.0614187784253185 385 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_227 fluconazole 33.516 µM 1.53979025616511 0.0772391874450167 no 255 0.0618057439025775 479 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1555 citronellol 128 µM 1.53887313909017 0.0773621523902347 no 256 0.0619176349506683 344 8842 A terpine precursor.
SGTC_1699 st031318 29.054 µM 1.53854826520719 0.0774057463793517 no 257 0.0619573084410078 395 5340658
SGTC_230 MPP+ 141.667 µM 1.53600288437511 0.0777479504687014 no 258 0.0622688364639567 384 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_556 4058-0063 51.5 µM 1.53391206886951 0.078029900289899 no 259 0.0625256432377596 418 6615692
SGTC_2702 st077768 96.8 µM 1.5331873934636 0.078127804748874 no 260 0.0626148447458243 375 6484119
SGTC_630 4356-0227 183 µM 1.53141468435565 0.078367692477738 no 261 0.0628334685866638 375 779312
SGTC_3189 9110682 49.47 µM 1.53066623340395 0.0784691423754556 no 262 0.0629259515759251 401 17122418
SGTC_1578 josamycin 24.2 µM 1.52925930456522 0.0786601160793538 no 263 0.0631000869518695 360 5282165 A P450 substrate.
SGTC_1931 st074438 57.1 µM 1.52912233469423 0.0786787268942101 no 264 0.0631170597197158 380 2787313
SGTC_1945 st075991 56.6 µM 1.52890426584513 0.078708363937922 no 265 0.0631440892901428 373 1084980
SGTC_849 0386-0493 241 µM 1.5261099545182 0.0790888789952918 no 266 0.0634912416896899 384 726119
SGTC_1354 1498-1681 81 µM 1.52576108330401 0.0791364841538475 no 267 0.0635346879469896 433 5754243
SGTC_86 0417-1630 471.922 µM 1.52492479160704 0.0792506885307407 no 268 0.0636389287294462 557 3634867
SGTC_3098 9119039 49.47 µM 1.51432793865189 0.0807086261209379 no 269 0.0649713429682386 416 17161528
SGTC_337 1315-0038 354 µM 1.51426883591013 0.0807168140195008 no 270 0.0649788346175817 400 1626437
SGTC_1668 st014914 51.6 µM 1.51195715477111 0.0810375589874656 no 271 0.0652723812733937 372 2839556
SGTC_2952 9073731 13.78 µM 1.51159935390474 0.0810872895832332 no 272 0.06531790808056 458 16457353
SGTC_495 decylubiquinone 155 µM 1.5112052674436 0.0811420901482443 no 273 0.0653680803931488 415 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1236 0330-0013 258 µM 1.51064075056248 0.0812206389755264 no 274 0.0654400027817804 376 4617066
SGTC_3074 9116018 49.47 µM 1.5099378513708 0.0813185229676923 no 275 0.0655296415664618 368 17027303
SGTC_2909 7941780 10.49 µM 1.50929230793062 0.0814084981099289 no 276 0.0656120497831984 421 1243215
SGTC_2356 9061756 188.97 µM 1.50620451047789 0.0818399107732362 no 277 0.0660073409629162 375 20104043
SGTC_3094 9117742 49.47 µM 1.50530924830813 0.0819653142756209 no 278 0.0661222942931202 456 17149698
SGTC_1841 st054148 70 µM 1.49820166866678 0.0829660482829298 no 279 0.0670404311207103 392 675442
SGTC_2376 9072922 81.32 µM 1.49697886578125 0.083139139354357 no 280 0.0671993786573869 453 17087968
SGTC_370 0180-0345 38.7 µM 1.49687166183829 0.0831543273014265 no 281 0.0672133275744311 377 3989527
SGTC_755 1995-0008 37.3 µM 1.49204245443979 0.0838406633501759 no 282 0.0678440080456267 413 689533
SGTC_1747 st037496 66.6 µM 1.49077300164594 0.084021784631465 no 283 0.0680105511663118 466 723305
SGTC_675 1309-0189 238 µM 1.48582779579953 0.0847301519635076 no 284 0.0686623379808044 415 4246530
SGTC_976 1348-1067 47.6 µM 1.48532324308315 0.0848026767577835 no 285 0.0687291088232065 493 5310671 YGL099W LSG1
SGTC_1032 k061-1018 98.7 µM 1.48523224645037 0.0848157616364325 no 286 0.0687411563450319 507 4005393
SGTC_93 0109-0045 59.227 µM 1.48169460047823 0.0853256323021913 no 287 0.0692107872294345 541 88733
SGTC_2058 5236698 133 µM 1.48166915917006 0.085329307381846 no 288 0.0692141735536449 439 766665
SGTC_166 k072-0058 166.424 µM 1.48145989661618 0.0853595405369698 no 289 0.0692420319511191 434 5846229
SGTC_202 3594-0513 34.79 µM 1.47025739642028 0.0869897558751768 no 290 0.0707460274612517 385 708429
SGTC_885 0865-0106 16.8 µM 1.46893003860829 0.0871844469747287 no 291 0.070925883067674 446 2793380
SGTC_2661 dactinomycin 12.96 µM 1.46683121219977 0.0874929574605283 no 292 0.0712109883511963 468 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_139 0099-0334 718.624 µM 1.46409342450268 0.087896613697844 no 293 0.0715842118323352 527 97690
SGTC_1163 k060-0048 49.9 µM 1.45974597409345 0.0885404480932658 no 294 0.0721799508004674 484 6809982
SGTC_963 1269-2853 151 µM 1.4585354581283 0.0887203428786507 no 295 0.0723465044848558 440 3668223
SGTC_617 3770-0098 35 µM 1.45807282329587 0.0887891668910759 no 296 0.072410235672039 425 5962639
SGTC_1349 flufenamic acid 69 µM 1.45680986029482 0.0889772543654765 no 297 0.0725844366601258 416 3371 A non-steroidal anti-inflammatory.
SGTC_867 0518-0118 155 µM 1.45666612194941 0.0889986794638379 no 298 0.0726042828745803 448 6848158
SGTC_3335 9143315 29.6265 µM 1.45355741477543 0.0894629918042372 no 299 0.0730345253760227 435 4899691
SGTC_1951 sophoraflavanone G 9.2 µM 1.45266279348981 0.0895969445036928 no 300 0.0731587010763291 482 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_3088 9117578 49.47 µM 1.44917275395584 0.0901209381519515 no 301 0.0736446721862609 410 678341
SGTC_1513 0337-0559 19 µM 1.44833516019913 0.0902470323527416 no 302 0.0737616694667201 391 775073
SGTC_1986 st071812 45 µM 1.44686841484956 0.0904681567431988 no 303 0.0739668904312928 401 11838594
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.43944843445635 0.0915929497979646 no 304 0.0750117549668247 363 4620898
SGTC_1588 farnesol 29.9 µM 1.43770786733482 0.091858296187068 no 305 0.0752584799590899 457 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.43229661386808 0.0926868684735502 no 306 0.076029475880286 467 5282309
SGTC_349 k015-0014 24 µM 1.43184442198515 0.092756357649386 no 307 0.0760941754855912 448 2196908
SGTC_3147 9097027 49.47 µM 1.42360237826266 0.0940296866684773 no 308 0.0772808035077077 474 25236841
SGTC_2189 6047310 154.431 µM 1.41962602106925 0.0946485941539577 no 309 0.0778582929001731 434 711535
SGTC_43 0570-0105 72.5 µM 1.41843868968709 0.094833979419121 no 310 0.0780313633343119 579 1114046 YDL195W SEC31
SGTC_2623 humulene 100 µM 1.41520887549399 0.0953396235265743 no 311 0.0785036315030756 408 6187145 An anti-inflammatory.
SGTC_911 3456-4043 236 µM 1.41382132793988 0.095557459731334 no 312 0.078707184862475 496 914281
SGTC_50 0929-0078 56.389 µM 1.41108933807751 0.0959874350648483 no 313 0.0791091366911815 467 1377751
SGTC_982 1491-0518 27.5 µM 1.41099086930712 0.0960029591331597 no 314 0.0791236531605904 429 3091256
SGTC_580 1123-0028 41 µM 1.40509820768345 0.0969353293601614 no 315 0.0799960385096578 540 1677248 YPR107C YTH1
SGTC_297 0986-0032 24 µM 1.4026140838042 0.0973303671957575 no 316 0.0803659748693911 422 2847425
SGTC_3050 9093513 49.47 µM 1.40004020313776 0.0977409231489165 no 317 0.0807506398892437 467 25236664
SGTC_1056 3448-1962 115 µM 1.39726864986116 0.0981844276435571 no 318 0.081166399760967 448 715507
SGTC_1256 0570-0116 285 µM 1.39579400790691 0.0984210001399274 no 319 0.0813882676639242 454 410638
SGTC_341 1486-1430 230 µM 1.39405754615539 0.0987001104334438 no 320 0.0816501139061258 473 2054753 YPL210C SRP72
SGTC_3130 9127414 49.47 µM 1.38895519448957 0.0995235884992496 no 321 0.0824231875517207 448 1494646
SGTC_1098 clofazimine 15.1 µM 1.38859832731559 0.0995813712783854 no 322 0.0824774631466323 544 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2460 5552655 174.22 µM 1.38361343947402 0.10039107264061 no 323 0.0832384254672477 487 5401989
SGTC_1663 st014140 55.4 µM 1.37831222187578 0.101257415903594 no 324 0.0840534556672204 557 4207120
SGTC_2907 7721985 69.9 µM 1.36912345280865 0.10277195799514 no 325 0.0854803442023138 490 3267881
SGTC_2345 9052315 157.45 µM 1.36708716538696 0.10310980670193 no 326 0.0857989928527531 492 6469265
SGTC_2277 7947813 106.88 µM 1.36625837274665 0.103247545765925 no 327 0.0859289408376629 489 1246798
SGTC_2654 protoveratrine a 100 µM 1.36102962519558 0.104119605078287 no 328 0.0867521637540923 480 5702278 A heart drug and vasodilator.
SGTC_2552 juarezic acid 87.02 µM 1.36092814942429 0.104136582040192 no 329 0.0867681983681613 579 1549512
SGTC_255 tunicamycin 200.472 nM 1.35974429289946 0.104334790288982 no 330 0.0869554281849185 527 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_124 0136-0217 7.121 µM 1.3578797929227 0.104647510022749 no 331 0.0872509151405716 597 3976905
SGTC_3222 9128301 49.47 µM 1.35567529391168 0.105018130662249 no 332 0.0876012517880277 502 4911358
SGTC_3172 9105863 49.47 µM 1.35359389511488 0.105368926820967 no 333 0.0879329878372786 397 2348785
SGTC_2529 gangaleoidin 93.61 µM 1.35321254959122 0.105433290056387 no 334 0.0879938685963062 479 4565183
SGTC_1833 st055984 71 µM 1.35151159151377 0.105720722902846 no 335 0.088265804646223 485 676288
SGTC_2881 9058953 51.95 µM 1.35079912207135 0.105841286251949 no 336 0.0883798947030336 535 17122249
SGTC_1788 fluconazole 20 µM 1.34765956181176 0.10637374325278 no 337 0.0888839519866303 498 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_861 0443-0273 110 µM 1.34677461073759 0.106524176310509 no 338 0.0890264170662923 517 6149169
SGTC_2193 5925765 200 µM 1.34635566363432 0.106595446775276 no 339 0.089093921096655 436 877370
SGTC_228 caffeine 993.056 µM 1.34608216884978 0.106641991740427 no 340 0.0891380092597756 462 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_3258 9138477 49.47 µM 1.34593805752915 0.106666523360486 no 341 0.0891612469587561 494 4970355
SGTC_2001 4023502 57.655 µM 1.34509895339019 0.106809442339717 no 342 0.0892966405852647 540 108941 YCR052W RSC6
SGTC_1966 st070145 16.1 µM 1.34412541675212 0.106975431395862 no 343 0.0894539171782536 507 3748532
SGTC_1745 st081495 74 µM 1.34302950265079 0.107162508485368 no 344 0.0896312104744253 579 13842402 YBL026W LSM2
SGTC_3334 9142812 21.919 µM 1.34105920572028 0.107499439488872 no 345 0.0899506153845401 518 45283678
SGTC_588 3970-1144 52.9 µM 1.33968436449602 0.107734996272755 no 346 0.090173991462342 553 1888707
SGTC_252 miconazole 1.30953 nM 1.32919862299719 0.109543798202704 no 347 0.0918912246352864 507 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_410 α-linolenic acid 100 µM 1.32734798094328 0.109865286911783 no 348 0.0921967994091201 554 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3000 9075062 71.4286 µM 1.32520193453338 0.110238939719416 no 349 0.0925520919574373 504 17057871
SGTC_1774 st048371 48.465 µM 1.32209853762614 0.110780889550062 no 350 0.0930676703495396 553 4242727
SGTC_2342 7990637 118.86 µM 1.32171627585784 0.110847776196105 no 351 0.093131323416373 563 2033102 YER133W GLC7
SGTC_2520 obtusaquinone 4.71 µM 1.31905389716394 0.111314431239849 no 352 0.0935755472414834 525 5967872
SGTC_1787 fluconazole 80 µM 1.31903787027335 0.111317244644811 no 353 0.0935782260936826 592 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1328 1441-0025 69.2 µM 1.31897945664077 0.11132749916723 no 354 0.0935879902565899 478 4562601
SGTC_1707 st032323 6.317 µM 1.31491977567313 0.112041834136872 no 355 0.0942684328747268 572 3132057 YMR211W DML1
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.31220325297786 0.112521655474971 no 356 0.0947257822903927 594 688761
SGTC_1112 tnp00069 1.16933 µM 1.31107044042218 0.11272217801888 no 357 0.0949169831895172 606 145826
SGTC_748 act1.228 77.9 µM 1.30761798366827 0.113334881251277 no 358 0.0955014570436944 600 4421505 YNR035C ARC35
SGTC_1550 gossypolone 36.6 µM 1.30688736520422 0.113464847183148 no 359 0.0956254838958293 565 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2992 9074591 71.4286 µM 1.30632062890985 0.1135657341358 no 360 0.0957217723656675 526 17741321
SGTC_1665 st014639 11.4 µM 1.30531255104058 0.11374534406406 no 361 0.0958932209994434 588 981133 YIL048W NEO1
SGTC_1198 1612-1005 86.7 µM 1.30476457511214 0.113843062212694 no 362 0.0959865125936746 561 6998509
SGTC_2226 7298446 200 µM 1.30278472639133 0.114196618485243 no 363 0.0963241333113171 471 3283010
SGTC_1117 retinoic acid 1.10837 µM 1.30120547104364 0.114479197972479 no 364 0.0965940665424971 587 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1697 st025554 27.742 µM 1.29796618401312 0.115060367151764 no 365 0.0971494776860614 512 1269519
SGTC_1435 4092-0789 56.7 µM 1.29066686759683 0.116377639697072 no 366 0.0984096091267554 559 2248285
SGTC_1485 3909-9022 254 µM 1.28768631355748 0.116918590612486 no 367 0.0989275898627912 558 714516
SGTC_2836 9010338 19.48 µM 1.28450289254133 0.117498326130955 no 368 0.09948302607209 509 2994051
SGTC_3020 9089140 49.47 µM 1.2843047345463 0.117534480021024 no 369 0.0995176754425485 542 17217859
SGTC_196 k015-0023 18.111 µM 1.28419300328877 0.117554868840578 no 370 0.0995372163559379 591 5211998
SGTC_295 k015-0027 31 µM 1.27661070607965 0.118944348012826 no 371 0.100869860116924 550 3887424
SGTC_3035 9091303 49.47 µM 1.27424000694483 0.119381156412233 no 372 0.101289185369432 525 25237002
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.26995685142757 0.120173207998367 no 373 0.102050000211784 546 75037 A free radical scavenger.
SGTC_572 0960-0087 17.7 µM 1.26740199949807 0.120647416785619 no 374 0.102505792609648 614 6796365
SGTC_1519 esterone 74 µM 1.26550174296816 0.121000978715125 no 375 0.102845761990882 576 698 A steroid.
SGTC_744 1594-0068 283 µM 1.26410838185158 0.121260690451083 no 376 0.103095564281922 632 668392
SGTC_2961 9083290 32.55 µM 1.26399345482689 0.12128212944707 no 377 0.103116188096675 528 17741490
SGTC_221 trifluoperazine 10.304 µM 1.26294071178362 0.121478636837184 no 378 0.103305243747003 731 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1367 1812-0510 76.9 µM 1.26190180789317 0.121672780302083 no 379 0.103492060696867 557 1142582 YDR527W RBA50
SGTC_2269 7935389 174.42 µM 1.26056125625422 0.121923615746093 no 380 0.103733482470367 570 97605
SGTC_1466 k213-0079 57.5 µM 1.25687614594535 0.122615020924677 no 381 0.104399243739778 582 3657981
SGTC_722 3534-0461 190 µM 1.25467809348908 0.123028729617147 no 382 0.104797820656762 578 658262
SGTC_1185 1319-0113 81.3 µM 1.25380972715082 0.123192439423277 no 383 0.104955586395382 517 4672763
SGTC_1947 st076332 61.6 µM 1.25311006272237 0.123324455512051 no 384 0.105082827208402 504 24208416
SGTC_691 1548-0686 185 µM 1.2517885191951 0.123574081130581 no 385 0.105323467334853 601 46495133
SGTC_277 nystatin 15.5 µM 1.25148990075742 0.123630535979365 no 386 0.105377898002755 607 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2220 6782180 200 µM 1.24838001183395 0.124219544805307 no 387 0.105945962682216 493 833803
SGTC_2755 lomerizine 42.69 µM 1.24423769134111 0.125007139364797 no 388 0.106706047782374 603 3949 A calcium channel blocker.
SGTC_945 3381-0768 11.3 µM 1.24217272867991 0.125401058387248 no 389 0.107086419656426 616 1126236 YIL048W NEO1
SGTC_412 gemfibrozil 100 µM 1.23949001411793 0.125914114654089 no 390 0.107582042300848 527 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1706 st031321 9.9705 µM 1.23736940209785 0.126320706075207 no 391 0.107974986459001 591 6103185
SGTC_2937 9044753 11.33 µM 1.23592393544962 0.126598373630032 no 392 0.108243419502268 618 6465530 YGL099W LSG1
SGTC_1454 4239-0054 42.6 µM 1.22994945902403 0.127750551732632 no 393 0.109358015780602 644 1340767
SGTC_787 4152-0075 138 µM 1.22929757372059 0.127876707444874 no 394 0.109480128324607 581 9566539
SGTC_2268 7933382 153.85 µM 1.2276927257017 0.128187653508733 no 395 0.109781169091514 675 935025 YOR257W CDC31
SGTC_1723 st034307 2.5525 µM 1.22711425562356 0.128299863166635 no 396 0.109889825276571 590 867466
SGTC_2727 riluzole 51.77 µM 1.22597505688927 0.128521040423543 no 397 0.110104030817733 552 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2233 sulbentine 40.3845 µM 1.22492891589168 0.128724383344912 no 398 0.110301002236669 666 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2098 5376439 882.5 nM 1.21961065295798 0.129761568194559 no 399 0.111306253043848 643 2844116
SGTC_1390 3413-2614 145 µM 1.21932818264179 0.129816817861971 no 400 0.11135982802061 622 3421432
SGTC_2817 7995342 71.43 µM 1.21505445489577 0.130654723806299 no 401 0.112172661457461 536 18879975
SGTC_1782 st039423 80.636 µM 1.21411596031718 0.130839224396012 no 402 0.112351723069921 566 2068169
SGTC_466 geldanamycin 89.2 µM 1.21383509678738 0.130894474929055 no 403 0.112405350573808 473 5288382 HSP90 inhibitor.
SGTC_797 k781-0471 270 µM 1.21373670677205 0.13091383369625 no 404 0.112424141285484 633 23738129
SGTC_3305 9127027 53.8275 µM 1.20821699970309 0.132003035869656 no 405 0.113481902254896 614 41905295
SGTC_1655 st012546 55.1 µM 1.20816488854712 0.132013348641529 no 406 0.113491922202236 570 720985 YLR208W SEC13
SGTC_1190 1486-1332 13 µM 1.20494571227388 0.132651499604845 no 407 0.114112130017117 606 4150046
SGTC_2792 7535235 81.82 µM 1.20439560465268 0.132760761999916 no 408 0.114218355040785 573 1281891
SGTC_1407 3909-7909 12.3 µM 1.20412482873107 0.132814566279544 no 409 0.114270667352799 636 4411780
SGTC_1898 st060199 18.6 µM 1.20311018563133 0.133016313544796 no 410 0.114466842160548 591 688866
SGTC_2364 9055074 200 µM 1.20228997317457 0.133179555177208 no 411 0.114625600177838 571 6470630
SGTC_2587 piperic acid 92.2 µM 1.20119999056633 0.133396700694825 no 412 0.11483681653709 574 5370536
SGTC_1152 3909-8331 15.9 µM 1.20107465607772 0.13342168534139 no 413 0.114861121537436 585 16001939
SGTC_1547 harmine 94.2 µM 1.19647927368197 0.13433996919566 no 414 0.115754791016771 700 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2360 9040895 200 µM 1.19257656443312 0.135123238490104 no 415 0.116517624320904 571 4914414
SGTC_313 3474-0040 5.03 µM 1.19134228779712 0.135371606905931 no 416 0.116759619599098 671 1043375 YIL048W NEO1
SGTC_2100 5377183 190 µM 1.19112536808181 0.135415289075737 no 417 0.116802186192821 682 2844202
SGTC_217 ketoconazole 989 nM 1.18820799116665 0.136003714015679 no 418 0.117375738067101 604 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1915 st067105 30.6 µM 1.18814139254251 0.136017167134659 no 419 0.117388854499641 639 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_59 0330-0160 1.33 µM 1.18715106449095 0.136217323823947 no 420 0.117584019616807 775 4293482
SGTC_2524 avocatin b 10.57 µM 1.18689136309815 0.136269845804324 no 421 0.117635237270366 575 6710748
SGTC_3128 9127691 49.47 µM 1.1811659118494 0.137431281321095 no 422 0.118768410058812 526 41316314
SGTC_360 0957-0399 1.01 µM 1.18039675761977 0.137587821432741 no 423 0.118921225466051 666 6752301 YPR165W RHO1
SGTC_2704 st078022 71.1 µM 1.17719269287998 0.138241229564804 no 424 0.119559302261537 644 54697681
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.17230851272823 0.139241329844642 no 425 0.12053660754724 618 6708514
SGTC_3341 9147222 25.867 µM 1.17190003108938 0.139325194381708 no 426 0.120618597295876 601 1939759
SGTC_1045 1348-1485 165 µM 1.17050615034471 0.139611627893542 no 427 0.120898670271286 690 6810614
SGTC_869 0564-0080 44.1 µM 1.16892619272271 0.139936782880191 no 428 0.12121668472964 653 6843321
SGTC_1904 st060225 78 µM 1.16798430123955 0.140130868639035 no 429 0.121406548671048 635 66595
SGTC_886 0866-0150 153 µM 1.16577334525815 0.140587175470107 no 430 0.12185304836645 692 271463
SGTC_1221 2958-7315 257 µM 1.16524098402409 0.140697197015975 no 431 0.12196073013242 635 4562705
SGTC_3326 9140064 16.379 µM 1.1652372441404 0.140697970133472 no 432 0.121961486842475 632 1868434
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.16469796275065 0.140809481823832 no 433 0.122070636965068 572 279621
SGTC_2666 tannic acid 100 µM 1.16456395640948 0.140837200726713 no 434 0.122097770378926 697 16134267 A thiamine antagonist.
SGTC_97 0535-0701 19.132 µM 1.16204843559204 0.141358217440304 no 435 0.122607895511025 614 2832013 YGL099W LSG1
SGTC_541 4513-1321 94 µM 1.15950237054824 0.141886889224987 no 436 0.123125735409757 640 747515
SGTC_792 4534-1957 155 µM 1.15793974202532 0.142212019771275 no 437 0.123444313903051 658 1717904
SGTC_1182 1222-0449 220 µM 1.15760736272283 0.142281241720803 no 438 0.123512151628532 633 658318
SGTC_643 k048-0106 28.4 µM 1.15470262420748 0.142887158274763 no 439 0.12410611226822 667 6763920
SGTC_344 k064-0035 6.43 µM 1.1541435586019 0.143003976898571 no 440 0.12422065889522 637 5088750
SGTC_122 0236-0016 402.397 µM 1.15237880858888 0.143373150573579 no 441 0.124582722592064 726 6808838
SGTC_2537 larixol 68.93 µM 1.15135150404244 0.143588351766609 no 442 0.124793828199583 715 6708759
SGTC_135 0933-0004 26.348 µM 1.15112650704104 0.14363551354205 no 443 0.124840097233273 636 21230617 YGL099W LSG1
SGTC_1048 3161-0300 24.5 µM 1.15094522393065 0.143673520023004 no 444 0.124877385534614 673 2165101
SGTC_3351 9150312 21.596 µM 1.15068119862117 0.143728885762676 no 445 0.124931707078881 668 4904905
SGTC_692 k241-0027 77.8 µM 1.14980726222223 0.143912251693274 no 446 0.125111631734827 649 3600480
SGTC_1425 4048-4433 7.33 µM 1.14750011531344 0.144397086159038 no 447 0.125587492749207 708 23734946
SGTC_145 3737-0113 38.366 µM 1.14272488557325 0.145404068359825 no 448 0.12657641707034 766 6849351
SGTC_2035 5154463 94.595 µM 1.13687516732095 0.146644057595862 no 449 0.12779523726983 682 2769623
SGTC_2452 5863136 48.41 µM 1.13564585251003 0.146905540263631 no 450 0.128052405314308 658 2184096
SGTC_3289 9119912 71.43 µM 1.12902543920169 0.148319116894389 no 451 0.129443551186438 666 17014829
SGTC_710 3448-4187 58 µM 1.125926857016 0.148983835203933 no 452 0.130098240157429 777 3946412
SGTC_1564 D-Arginine 115 µM 1.12464470187762 0.149259468712712 no 453 0.130369811556624 659 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1281 0884-0031 11.8 µM 1.12442087228844 0.14930762175165 no 454 0.130417260747486 715 1548255
SGTC_542 3381-0244 89.3 µM 1.12387505465405 0.149425088392644 no 455 0.130533017620024 753 1112843
SGTC_340 k038-0059 454 µM 1.12203210180123 0.14982217011187 no 456 0.130924395488909 700 23733424
SGTC_261 5-fluorouridine 15.376 µM 1.11845414999274 0.150595081772499 no 457 0.131686539148346 699 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1669 st015249 58.4 µM 1.11789584529176 0.150715926243002 no 458 0.131805739854632 698 722793
SGTC_2071 5230951 39.92 µM 1.11685036619351 0.150942392725464 no 459 0.132029154775864 730 1799272
SGTC_2359 9039622 200 µM 1.11588445341198 0.151151825134831 no 460 0.132235798655073 734 6463596
SGTC_2299 7976368 114.88 µM 1.11547001078748 0.151241745201203 no 461 0.132324531327535 681 2979718
SGTC_3283 9109332 35.8195 µM 1.11454529231427 0.151442506157048 no 462 0.132522662595759 600 17027281
SGTC_1066 ketoconazole 628 nM 1.11272680611862 0.151837825159237 no 463 0.132912889567306 738 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1285 0929-0069 65.5 µM 1.11214169563614 0.151965167441142 no 464 0.133038615849106 695 1206237
SGTC_532 1548-0774 215 µM 1.10705184494078 0.153075904538664 no 465 0.134135756862108 722 5932993
SGTC_2732 terfenadine 20 µM 1.10659791311968 0.153175224909933 no 466 0.134233904987909 650 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1571 st070080 73.4 µM 1.10631447307803 0.153237263300443 no 467 0.134295214770849 701 4315245
SGTC_3099 9120367 49.47 µM 1.10623062786467 0.153255618245674 no 468 0.134313354679155 692 24824940
SGTC_204 PMA1.184 62.41 µM 1.10402767350568 0.153738399186875 no 469 0.134790566719253 757 2252213 YGL008C PMA1
SGTC_2157 5649910 96.377 µM 1.10335200622478 0.15388667427476 no 470 0.134937165079841 705 2858091
SGTC_2362 9071156 126 µM 1.10223208454733 0.154132649299714 no 471 0.135180393344074 710 653133
SGTC_3081 9117243 49.47 µM 1.09856526473417 0.154939833514902 no 472 0.13597886781258 685 45595589
SGTC_706 4262-0057 46.9 µM 1.09799356863235 0.155065933214088 no 473 0.136103648811329 675 883298
SGTC_3330 9141424 71.43 µM 1.09783690086073 0.155100501439795 no 474 0.136137857511222 754 27261020
SGTC_136 0097-0015 404.482 µM 1.09738055703173 0.155201221188912 no 475 0.136237534569604 764 4861337
SGTC_3272 9137413 49.47 µM 1.09617044773293 0.155468513685036 no 476 0.136502094866782 682 17614870
SGTC_85 0868-0259 160.055 µM 1.0953910599325 0.15564082785891 no 477 0.136672674540465 674 83173
SGTC_203 k066-0004 30.888 µM 1.09344638979704 0.156071322348472 no 478 0.137098927499588 832 6795412
SGTC_452 diindolylmethane 8 µM 1.09273199598838 0.156229665649753 no 479 0.137255743609145 652 3071 Inhibits expression of several cancer promoting factors.
SGTC_425 3825-7017 13.1 µM 1.09251796080595 0.156277126519893 no 480 0.137302750170761 745 3397440
SGTC_1474 0330-0125 5.35 µM 1.09168385120234 0.156462175364806 no 481 0.137486042827179 721 X1474
SGTC_2292 7671323 168.05 µM 1.08945648635495 0.156957027422141 no 482 0.137976316789849 712 937504
SGTC_3116 9124943 49.47 µM 1.08899041991216 0.157060703191202 no 483 0.138079055175105 652 41905195 YPL160W CDC60
SGTC_2733 amorolfine 100 µM 1.08600228965247 0.15772647812025 no 484 0.13873898962615 630 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1374 2889-5571 141 µM 1.0841829275264 0.158132750542824 no 485 0.139141849883201 760 2853281
SGTC_1901 st060216 58.6 µM 1.08415428420828 0.158139152222307 no 486 0.139148198715305 722 688792
SGTC_3135 9127742 49.47 µM 1.08401183743268 0.158170991095155 no 487 0.139179775173557 660 3643468
SGTC_1392 3455-1037 33.9 µM 1.08268406698703 0.158467968962284 no 488 0.139474339246523 712 981132
SGTC_1014 4130-3005 69.3 µM 1.08176420444218 0.158673925787422 no 489 0.139678657978046 730 743608
SGTC_3194 9111903 49.47 µM 1.08112249270782 0.158817708643564 no 490 0.13982131464351 699 17087251
SGTC_2993 9054257 71.4286 µM 1.07998923028837 0.159071837570371 no 491 0.140073488016689 709 6470217 YGL055W OLE1
SGTC_2906 7926292 26.41 µM 1.07787181063717 0.15954737276927 no 492 0.140545483513148 720 2966319
SGTC_2047 4141938 200 µM 1.07664922504881 0.15982236727144 no 493 0.140818502023116 669 3807862
SGTC_2725 haloperidol 53.21 µM 1.07545256677465 0.16009183007154 no 494 0.141086078893365 724 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2653 dihydrofissinolide 100 µM 1.071722711897 0.160933621286424 no 495 0.14192229823635 724 6857746
SGTC_2449 5812982 45.77 µM 1.0660903977766 0.16221024423143 no 496 0.143191389920508 691 776185
SGTC_144 4161-2749 112.381 µM 1.06604085823586 0.162221502060144 no 497 0.143202586234976 657 797501 YMR168C CEP3
SGTC_1756 st041558 35.5 µM 1.06536033166086 0.162376202776424 no 498 0.143356450291678 818 3955792
SGTC_1282 0886-0010 32.4 µM 1.06362220661687 0.162771757761302 no 499 0.143749939208891 834 2836211 YNL267W PIK1
SGTC_430 0958-0115 16.4 µM 1.06336998852879 0.162829208487545 no 500 0.143807098596221 713 6833180
SGTC_3079 9117512 49.47 µM 1.06312015176636 0.162886129789391 no 501 0.143863733427063 805 7185044
SGTC_767 0929-0023 86 µM 1.06219866961712 0.163096186579349 no 502 0.144072751843563 837 1204563
SGTC_2213 7173844 200 µM 1.06210711187306 0.163117067268994 no 503 0.144093530928337 757 892728
SGTC_2304 7443016 91.4 µM 1.05943234641442 0.163727841907776 no 504 0.144701462465006 674 939854
SGTC_612 0302-0167 22.4 µM 1.05662666167781 0.16437010481285 no 505 0.14534100375903 818 235821
SGTC_3112 9123419 49.47 µM 1.05544570113311 0.164640932008342 no 506 0.145610765376978 785 17015854
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.05516363728975 0.164705659868056 no 507 0.145675245753331 731 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1642 st009582 77.7 µM 1.05480281894355 0.164788484299741 no 508 0.145757757551992 707 6739311
SGTC_3181 9108277 49.47 µM 1.05348445927127 0.165091337908 no 509 0.146059506580131 728 17097298
SGTC_2558 carylophyllene oxide 100 µM 1.05315933303586 0.165166081265585 no 510 0.146133986643393 796 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_984 1492-0255 2.91 µM 1.05120668896425 0.165615435846648 no 511 0.146581835860481 713 1585198
SGTC_302 1094-0063 18.9 µM 1.05097448983882 0.165668923499692 no 512 0.146635153171138 684 5440289
SGTC_512 prima-1 270 µM 1.04411089145066 0.167255014455842 no 513 0.148217043692227 782 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2228 7354201 200 µM 1.04306264128782 0.167498110605821 no 514 0.148459640865052 761 753451
SGTC_1614 st002383 48.6 µM 1.04274217185043 0.167572474999873 no 515 0.148533860271992 761 1947235
SGTC_646 4092-0839 27.3 µM 1.04150940532512 0.167858734620035 no 516 0.148819595190562 774 877796
SGTC_840 0245-0196 390 µM 1.04139628669387 0.16788501755697 no 517 0.148845832608402 812 3827528
SGTC_3256 9138902 49.47 µM 1.03726145550217 0.168847557116753 no 518 0.149807011992118 801 17228773
SGTC_1376 2910-0861 41.3 µM 1.03632077544163 0.169067030364539 no 519 0.150026258486799 789 1112859
SGTC_563 tetrahydrosecaminediol 614 µM 1.03373919391982 0.169670288738344 no 520 0.150629052439722 807 334274 A psychoactive constituent of the cannabis plant.
SGTC_2416 tofa 880 nM 1.03261410372465 0.169933628826757 no 521 0.150892262642072 682 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3229 9132204 49.47 µM 1.03250574720499 0.169959004721771 no 522 0.150917628354696 751 17682924
SGTC_2283 7944793 200 µM 1.03219623374639 0.170031502719367 no 523 0.150990099519757 756 2970533
SGTC_1042 0350-0096 82 µM 1.03093328250184 0.170327531901943 no 524 0.151286053823946 735 3122515
SGTC_1675 st018485 24.5 µM 1.03046508090087 0.170437359747422 no 525 0.151395868045195 770 3323024
SGTC_1825 st052143 62.6 µM 1.02899774420911 0.170781852265541 no 526 0.151740367443342 737 674173
SGTC_2421 5690543 90.72 µM 1.02885622545471 0.170815100736424 no 527 0.151773620554954 774 3397993
SGTC_22 0964-0034 14.468 µM 1.02837262071047 0.170928750283236 no 528 0.151887291244583 800 138402
SGTC_3348 9149464 3.537 µM 1.02827841208718 0.170950895412283 no 529 0.151909441444072 763 1951442
SGTC_926 2268-1401 59.4 µM 1.02791790664025 0.17103565449514 no 530 0.151994222796706 776 2931578
SGTC_1913 st060213 96.1 µM 1.02760678691389 0.171108824018391 no 531 0.152067415194232 806 688959
SGTC_2802 7925815 54.55 µM 1.02736070899692 0.171166711105247 no 532 0.152125322772541 768 1262923
SGTC_1812 st052057 4.327 µM 1.02715788867013 0.171214431739751 no 533 0.152173061889833 790 3645418
SGTC_1514 1189-1591 158 µM 1.02560355449749 0.171580426039286 no 534 0.152539245665786 799 767698 YMR146C TIF34
SGTC_2797 7859098 81.82 µM 1.02473508036744 0.17178514050084 no 535 0.152744102876226 767 972681
SGTC_2136 5328288 199.296 µM 1.02069253180466 0.172740091447073 no 536 0.153700066955088 682 262395
SGTC_2386 9075165 157.42 µM 1.02044852913356 0.172797839055982 no 537 0.15375789411358 776 16452277
SGTC_429 1112-0049 25.5 µM 1.01997945976295 0.172908887294803 no 538 0.153869101170265 735 2836170
SGTC_2971 9092186 9.93 µM 1.0187386818795 0.173202850231733 no 539 0.154163521605894 712 25236400
SGTC_220 paclitaxel 373.376 µM 1.01804208685179 0.173368025727547 no 540 0.154328977755065 705 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_977 1348-1378 135 µM 1.0168565556088 0.17364936746975 no 541 0.154610836535712 810 X977
SGTC_1863 st057641 20.1 µM 1.01387979983138 0.174357069275351 no 542 0.155320055653905 834 3921635
SGTC_2046 4110841 106 µM 1.01385401371501 0.174363207729373 no 543 0.155326208622332 804 44119630 YMR134W ERG29
SGTC_2504 purpurogallin 52.29 µM 1.01215746970482 0.174767376226978 no 544 0.155731383868137 757 5281571 An antioxidant.
SGTC_1124 fisetin 1.16336 µM 1.01169591647687 0.174877435096352 no 545 0.155841734298763 730 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_978 1416-0512 87.4 µM 1.01051245551889 0.175159836147777 no 546 0.156124917507937 817 6814003
SGTC_1419 3993-2473 62.6 µM 1.00549150990241 0.176361163804271 no 547 0.157330117800326 808 704026
SGTC_2854 9024559 71.43 µM 1.00441318411471 0.176619845930833 no 548 0.157589748900533 751 3163529
SGTC_3138 9097216 49.47 µM 1.00280639444002 0.17700574738793 no 549 0.157977141496805 836 25237486
SGTC_2674 ligustilide 100 µM 1.00261550063468 0.177051629588953 no 550 0.158023206988898 758 5319022 A signalling regulator.
SGTC_1628 st004252 77.7 µM 1.00228887762931 0.177130152350915 no 551 0.158102046390175 799 692968
SGTC_1036 k216-0215 33.5 µM 1.00206951431639 0.177182901378413 no 552 0.158155010219485 797 622330
SGTC_2786 7743617 45.45 µM 1.00107049779422 0.177423254571105 no 553 0.158396363449622 708 583674
SGTC_2236 dapsone 200 µM 0.999865779365592 0.177713371176636 no 554 0.158687733575183 852 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1050 3232-1156 69.3 µM 0.997313184372191 0.178329067569553 no 555 0.159306258045211 775 700529
SGTC_9 0092-0002 10.449 µM 0.997167273258868 0.178364302493817 no 556 0.159341661699852 805 759368
SGTC_2778 tioconazole 65.09 nM 0.996851004365262 0.178440690832174 no 557 0.159418418396562 783 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2115 tiliquinol 12.7705 µM 0.996587420101765 0.178504370009561 no 558 0.159482407318598 788 71208 A bioactive hydroxyquinoline.
SGTC_1375 2910-0797 186 µM 0.994562217900679 0.178994114883394 no 559 0.1599746154617 786 742508
SGTC_1090 efavirenz 20.7 µM 0.994138194364486 0.179096761392279 no 560 0.160077796413876 807 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2286 7945697 125 µM 0.994072235117986 0.179112731961836 no 561 0.16009385070144 774 1245733
SGTC_3269 9137823 49.47 µM 0.993654580184254 0.179213878642537 no 562 0.160195531126209 739 17682936
SGTC_1471 k673-0312 37 µM 0.993642997276556 0.17921668427551 no 563 0.160198351651233 810 24099884
SGTC_2825 7998094 58.44 µM 0.993080670436806 0.179352925329958 no 564 0.160335321503667 764 2987815
SGTC_1883 5-benzylidenerhodanine 20 µM 0.992597525949751 0.179470034010884 no 565 0.160453065469165 852 1273210
SGTC_397 arbidol 50 µM 0.992399922658936 0.179517944628526 no 566 0.160501238341452 863 131410 A RNA synthesis inhibitor.
SGTC_635 k038-0028 24.7 µM 0.991272178777189 0.179791529673831 no 567 0.160776347082437 836 4035102
SGTC_2787 5284540 71.43 µM 0.990958560161719 0.179867658509847 no 568 0.160852907811984 811 736958
SGTC_3263 9137018 49.47 µM 0.990181651031212 0.180056335227418 no 569 0.161042669743341 754 43844957
SGTC_126 0417-1624 672.48 µM 0.990001159908998 0.180100186284716 no 570 0.161086776040427 973 41912 YDL195W SEC31
SGTC_633 0437-0093 97.7 µM 0.988459580314335 0.180474992488746 no 571 0.16146381027177 805 2831118
SGTC_2265 7929201 200 µM 0.986765769090278 0.18088737467646 no 572 0.161878739718233 822 1265108
SGTC_1985 st071382 65.5 µM 0.98521508271755 0.181265428498403 no 573 0.162259216759453 822 6123237
SGTC_1280 0880-0253 10.1 µM 0.98447164792542 0.181446851566971 no 574 0.162441832523801 824 6836607
SGTC_581 0958-0271 211 µM 0.983659753804318 0.181645110817888 no 575 0.162641417232865 858 4591145
SGTC_1993 st073995 70.8 µM 0.983656616364972 0.181645877222955 no 576 0.162642188806419 828 3098394
SGTC_450 aminopyrene 156 nM 0.983576385085651 0.181665476587009 no 577 0.162661920461674 818 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.983530109298307 0.181676781707473 no 578 0.162673301991429 832 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_323 4013-0906 34.3 µM 0.982424618274838 0.181946982721728 no 579 0.162945351508178 845 2910086
SGTC_2239 6685329 187.64 µM 0.978356255929875 0.182943523015779 no 580 0.163949077714957 808 805680
SGTC_1775 st081588 35.1725 µM 0.97553687735353 0.183636120435959 no 581 0.164647009194649 860 1426443 YGL099W LSG1
SGTC_1963 st076565 50.3 µM 0.975243720917256 0.183708229747867 no 582 0.164719689811269 810 4914280
SGTC_1348 1493-0373 93.8 µM 0.974177094184113 0.183970742664145 no 583 0.16498430790661 815 3010129
SGTC_2868 9035608 32.47 µM 0.973494185913603 0.184138939269726 no 584 0.165153874220998 812 6462614
SGTC_2719 novobiocin 32.65 µM 0.972881985198798 0.184289802325286 no 585 0.165305979686944 792 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_3077 9117319 49.47 µM 0.972700977790708 0.184334422245318 no 586 0.165350969576707 786 17154678
SGTC_1557 sumaresinolic acid 42.3 µM 0.972355361305349 0.184419638421056 no 587 0.165436895509857 773 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_605 1315-0399 119 µM 0.972120540436542 0.18447755049635 no 588 0.165495292310989 876 24020461
SGTC_1530 rhein 70.4 µM 0.971730110443662 0.184573864296041 no 589 0.165592416525858 880 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2082 5219693 150 µM 0.969479163479997 0.185129752122883 no 590 0.166153085716344 820 2834649
SGTC_2657 nystatin 74.44 µM 0.967935285329563 0.185511624705572 no 591 0.166538345329425 861 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2694 st077685 81.9 µM 0.967383738396393 0.185648166248225 no 592 0.166676118127356 796 2838096
SGTC_1866 st057638 64 µM 0.96700201510392 0.185742702572485 no 593 0.166771513151269 813 688802
SGTC_3173 9105693 49.47 µM 0.96640141518195 0.185891505600605 no 594 0.16692167810605 873 17096658
SGTC_595 3909-8003 73.7 µM 0.966253818128971 0.185928085164009 no 595 0.166958594394722 828 699517
SGTC_949 1165-0505 146 µM 0.963824079495195 0.186530898307914 no 596 0.167567066053606 878 6244267
SGTC_779 1360-0071 233 µM 0.963648080693724 0.186574610208597 no 597 0.167611196283638 904 7566
SGTC_439 amiodarone 34.4 µM 0.963234602540371 0.186677328565335 no 598 0.167714901927276 840 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2130 NSC 7 2.4545 µM 0.961178308928198 0.187188683368893 no 599 0.168231260403613 876 21448
SGTC_615 k087-0205 167 µM 0.960963100643464 0.187242250943401 no 600 0.168285360682574 787 9642773
SGTC_2118 5526350 200 µM 0.960646528252378 0.187321066320488 no 601 0.168364962781425 866 743594
SGTC_2248 tofa 1.1 µM 0.960628022571533 0.187325674217765 no 602 0.168369616782226 810 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_88 0180-0332 8.668 µM 0.956753014958584 0.188292090675522 no 603 0.169345966234023 860 3101745
SGTC_645 0845-0943 5.41 µM 0.955322178137943 0.188649713720185 no 604 0.169707397633693 815 1885106
SGTC_2695 st077686 51.995 µM 0.95406784564124 0.1889635654995 no 605 0.170024650459282 802 2876092
SGTC_2077 5212015 200 µM 0.950846538068175 0.189771054983225 no 606 0.170841142129224 807 780900
SGTC_1174 0739-0097 51.1 µM 0.94982078395688 0.190028626929174 no 607 0.171101661643262 838 728447
SGTC_2804 7954240 19.48 µM 0.949421637768514 0.190128912563876 no 608 0.171203104837664 886 828705
SGTC_1439 4092-1168 46 µM 0.944091698867312 0.191471176576259 no 609 0.172561395474498 874 2886240
SGTC_702 1488-0190 94 µM 0.940474531346892 0.192385403822271 no 610 0.173487103813909 873 949357
SGTC_2947 9072639 7.68 µM 0.938794467927803 0.192810940638263 no 611 0.173918139884778 946 16488146
SGTC_2447 5741742 33.78 µM 0.934938603372935 0.193789749757301 no 612 0.174909970624587 891 1776504
SGTC_91 0417-1751 58.384 µM 0.934035652972846 0.194019400201241 no 613 0.175142751134051 985 6795624
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.933458391903814 0.194166303823174 no 614 0.175291671891842 883 2333 A French combination drug.
SGTC_2720 fluspirilene 36.88 µM 0.93242426744983 0.194429641139869 no 615 0.175558654123535 797 3396 An atypical antipsychotic.
SGTC_1302 1159-0335 255 µM 0.931725060583724 0.194607815629461 no 616 0.175739315877208 843 649284
SGTC_2885 9057732 51.95 µM 0.929826801134222 0.195092037937567 no 617 0.176230383673418 872 6471414
SGTC_1495 4469-0029 237 µM 0.928650519415901 0.19539245991822 no 618 0.176535115725041 956 793680
SGTC_1355 1499-0035 1.68 µM 0.927427497678588 0.195705117094393 no 619 0.176852309595841 856 1548538
SGTC_17 0960-0276 49.807 µM 0.927408612878594 0.195709947244563 no 620 0.176857210240245 928 6821114
SGTC_1438 4092-1045 4 µM 0.926330277901135 0.195985872142764 no 621 0.177137182749895 889 1351342
SGTC_2237 6667747 47.222 µM 0.923307456244169 0.196760610372373 no 622 0.17792350165428 832 729940 YDL015C TSC13
SGTC_1264 0783-0040 158 µM 0.922994937278345 0.196840813502817 no 623 0.178004921785777 850 2855798
SGTC_1303 1160-0052 261 µM 0.922527456974556 0.196960821995127 no 624 0.178126757626268 913 3562476
SGTC_3286 9117135 37.221 µM 0.922473184931691 0.196974757228578 no 625 0.178140905541441 836 3438150
SGTC_1681 tripelennamine 100 µM 0.922464224690251 0.196977057974318 no 626 0.178143241411375 842 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1428 4049-0204 61.7 µM 0.921554279884627 0.197210791695495 no 627 0.178380557954619 914 X1428
SGTC_758 0868-0029 16 µM 0.919987479374998 0.19761364219478 no 628 0.17878965110101 917 762687
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.919087642348021 0.197845229984458 no 629 0.179024866212727 1045 688664
SGTC_551 k048-0028 34.9 µM 0.918869862858438 0.197901303735557 no 630 0.17908182246834 933 6836383
SGTC_2340 7987427 183.45 µM 0.918622810474803 0.197964926277694 no 631 0.179146448315685 843 2239331
SGTC_1658 st012944 20 µM 0.918381635292387 0.198027047199622 no 632 0.179209550908994 850 24207260
SGTC_398 bronopol 33.3 µM 0.917236967433962 0.198322046582589 no 633 0.179509239616799 891 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1814 st052110 31.539 µM 0.916294113666022 0.198565234302238 no 634 0.179756327266856 888 674163
SGTC_1760 st045453 10.4495 µM 0.91384182649937 0.199198587854575 no 635 0.180399982439552 950 3323419 YIL048W NEO1
SGTC_507 nimesulide 162 µM 0.913519829768222 0.199281840407825 no 636 0.180484604630114 913 4495 A COX2 inhibitor.
SGTC_3245 9134821 49.47 µM 0.912971237799831 0.19942372762046 no 637 0.180628834406967 926 17014901
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.911526299564945 0.199797735771281 no 638 0.181009067474312 874 364106
SGTC_2278 7948257 134.34 µM 0.911157931121504 0.199893151795247 no 639 0.181106083180275 912 1247028
SGTC_1116 jasmonic acid 1.58368 µM 0.908596247957463 0.200557445094763 no 640 0.181781643917666 901 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_364 0083-0097 67.7 µM 0.907955627261038 0.20072377723559 no 641 0.181950832915242 881 5207356
SGTC_289 k017-0060 526 µM 0.905161657963871 0.201450177002058 no 642 0.18268987559562 899 5512909
SGTC_2964 9083345 53.42 µM 0.904800515795157 0.201544184635576 no 643 0.18278553918712 849 17741579
SGTC_384 k007-0144 5.16 µM 0.903029656963834 0.202005530901575 no 644 0.183255077605941 932 6824886
SGTC_2450 5739737 12.93 µM 0.902116363599101 0.202243710030306 no 645 0.183497528596563 855 2262825
SGTC_3234 9132280 49.47 µM 0.900911407886098 0.202558209116549 no 646 0.183817712620379 896 17612295
SGTC_154 3389-1638 511.116 µM 0.900755223817133 0.202598995282039 no 647 0.183859239726604 792 5238686
SGTC_1420 4'-methoxyflavone 42 µM 0.898246795215142 0.203254722748504 no 648 0.184526995277489 927 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3241 9133421 49.47 µM 0.898101871951992 0.203292645753535 no 649 0.184565620569005 930 17018221
SGTC_2945 9067681 61.76 µM 0.895949062411883 0.203856482406883 no 650 0.185139984439143 902 16456930
SGTC_333 3486-0131 40.1 µM 0.895533758606852 0.203965360674479 no 651 0.185250914003089 967 6744690
SGTC_2333 9017922 200 µM 0.894878548711671 0.204137204444104 no 652 0.185426007494766 919 3163164
SGTC_194 1486-1323 56.904 µM 0.894635352411025 0.20420101017006 no 653 0.185491023625539 910 5178754
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.893928725477023 0.204386470353518 no 654 0.185680013630902 996 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1967 st070177 51.4 µM 0.893409355962224 0.204522847162717 no 655 0.185818997085136 892 5729214
SGTC_374 0880-0231 82.3 µM 0.891982330203113 0.204897836378345 no 656 0.186201201729726 928 6833587
SGTC_2315 7733312 200 µM 0.890928591854897 0.205174996535467 no 657 0.18648374013511 856 726316
SGTC_1694 st024011 44.9 µM 0.889678798833393 0.205504012727269 no 658 0.186819190617524 973 2787533
SGTC_3250 9135583 49.47 µM 0.889392056203268 0.205579543760131 no 659 0.186896206362561 899 7699353
SGTC_3299 9121982 43.1275 µM 0.888854062788745 0.205721301359081 no 660 0.187040758156115 923 17594604 YPL160W CDC60
SGTC_3037 9091026 49.47 µM 0.887684454558971 0.206029685234491 no 661 0.187355255126252 1002 25236398 YIL048W NEO1
SGTC_1916 st067606 49.2 µM 0.886519579005058 0.20633709359653 no 662 0.187668804236802 957 19590279
SGTC_72 0744-0168 198.391 µM 0.886251527582356 0.206407870290451 no 663 0.187741001390992 881 677577
SGTC_579 4491-1009 110 µM 0.885759719260519 0.206537765489427 no 664 0.187873509988886 1124 1271041
SGTC_2949 9072542 2.23 µM 0.884678161220303 0.206823594202866 no 665 0.18816511876046 926 16457352
SGTC_2566 crystal violet carbinol 226 nM 0.884536543290865 0.206861037605798 no 666 0.188203322338467 788 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.883593828722776 0.207110391060256 no 667 0.188457755807637 937 688667
SGTC_377 3970-0964 33.1 µM 0.882100150354718 0.207505841478769 no 668 0.188861325463883 1003 16481235
SGTC_2087 5276107 200 µM 0.879708016524329 0.208140086223703 no 669 0.189508752741004 929 144405
SGTC_2153 5569715 200 µM 0.877952089976766 0.208606375730775 no 670 0.189984859565477 934 2054701
SGTC_1867 st057372 64 µM 0.876293380477862 0.209047414180259 no 671 0.19043528135902 947 688837
SGTC_2706 st078239 82.5 µM 0.87322442161297 0.209864873780179 no 672 0.191270383012619 966 15434492
SGTC_470 aa-861 153 µM 0.871665395915171 0.21028086049101 no 673 0.191695471662713 933 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_900 1112-0045 141 µM 0.871587389325783 0.210301687294829 no 674 0.191716756362294 842 56211 YIL048W NEO1
SGTC_1318 1280-3875 124 µM 0.867449014948285 0.211408318141116 no 675 0.192848017870618 935 373245
SGTC_1440 4100-1550 40 µM 0.867164716610857 0.2114844665337 no 676 0.192925882752185 990 742806
SGTC_2172 5754775 163.918 µM 0.866579107390186 0.211641370679208 no 677 0.193086332487119 863 2263357
SGTC_2900 5328528 85.29 µM 0.865656158047738 0.211888797713937 no 678 0.193339374600388 1025 795359
SGTC_1307 1187-1599 12.2 µM 0.864236568884647 0.212269695568401 no 679 0.19372897364782 947 1538471
SGTC_2166 5933061 31.504 µM 0.864036686247586 0.21232335931254 no 680 0.193783868841092 996 2877375
SGTC_2232 chlorophetanol 41.5365 µM 0.861319423998269 0.213053665873627 no 681 0.194531070271391 1068 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_445 e6 berbamine 66 µM 0.860807354092516 0.213191456561457 no 682 0.194672076989356 1028 6610268 A calcium/calmodulin antagonist.
SGTC_2029 5175081 200 µM 0.85892215569784 0.213699184155143 no 683 0.195191732479653 1017 1380876
SGTC_3072 9116419 49.47 µM 0.857974731865321 0.213954613047838 no 684 0.195453208123113 930 17170162
SGTC_1212 0520-0165 585 µM 0.853854153231322 0.215067601491128 no 685 0.196592902470097 942 5403258
SGTC_489 paxilline 115 µM 0.852400727665059 0.215460979387035 no 686 0.196995858212954 948 105008 A toxic potassium channel blocker.
SGTC_1340 1486-1359 257 µM 0.851092355403971 0.215815454482946 no 687 0.197359025820511 979 4309068
SGTC_2302 7771753 200 µM 0.850970604019607 0.215848457561514 no 688 0.197392841186334 974 2203047
SGTC_409 arachidonic acid 100 µM 0.850551218221742 0.215962162618446 no 689 0.197509348687164 980 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2927 9011802 47.9 µM 0.847127417681625 0.216891730277432 no 690 0.198462052173884 935 43912568
SGTC_3036 9090181 49.47 µM 0.844767817808596 0.217533709741473 no 691 0.199120243101745 962 25236586
SGTC_74 000s-0487 160.283 µM 0.844736608833357 0.21754220815125 no 692 0.199128957390266 1021 677548
SGTC_2214 7179297 48.276 µM 0.844581785921584 0.217584370284341 no 693 0.199172191028096 993 769744
SGTC_1122 capsaicin 818.572 nM 0.843954912597379 0.217755131692488 no 694 0.199347300516231 979 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1469 k284-2957 126 µM 0.843724946582194 0.217817794221143 no 695 0.199411561977328 992 23884841
SGTC_2768 sulfasalazine 50.2 µM 0.839881841049456 0.21886652503375 no 696 0.2004873200348 1015 5384001 An antioxidant and salicylic acid derivative.
SGTC_1067 clotrimazole 1.36 µM 0.83866550544524 0.219199050580037 no 697 0.200828520204857 1004 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2128 5255449 168.493 µM 0.83860793391264 0.219214796856869 no 698 0.200844678505879 1045 736008
SGTC_226 1,3-diallylurea 8.28947 mM 0.838488506261536 0.219247463352591 no 699 0.200878200127959 965 74537 YKL182W FAS1
SGTC_1476 4112-3294 3.34 µM 0.837734930392696 0.219453650009653 no 700 0.201089795437927 1000 704369
SGTC_2575 plumbagin 510 nM 0.835005009361947 0.220201518550448 no 701 0.201857443957456 937 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2231 micatex 6.853 µM 0.834802979472848 0.220256923155939 no 702 0.201914324013945 1011 20737 An antifungal of unknown mechanism.
SGTC_2656 pseudo-anisatin 100 µM 0.834394072604777 0.220369086088936 no 703 0.202029478149317 999 6708809 A neurotoxin.
SGTC_1685 st024049 53.0905 µM 0.831189244614052 0.221249301826944 no 704 0.202933364885938 967 1941139
SGTC_485 niflumic acid 177 µM 0.83076956498673 0.221364716843812 no 705 0.203051909538805 980 4488 A COX2 inhibitor.
SGTC_2730 imipramine 71.33 µM 0.830027879690844 0.221568769975073 no 706 0.203261510484494 1074 3696 A tricyclic antidepressant.
SGTC_927 2425-1185 123 µM 0.82938469856857 0.221745809552915 no 707 0.203443378560304 989 730375
SGTC_2002 4023503 131 µM 0.829297773042009 0.221769742538818 no 708 0.203467965361434 1091 4736863 YCR052W RSC6
SGTC_2581 avocatin a 64 µM 0.828091264478399 0.222102079842262 no 709 0.203809408147563 984 6710728 A skin care supplement.
SGTC_2771 fluoxetine 41.05 µM 0.827893323000917 0.222156630696116 no 710 0.203865458322229 969 3386 A selective serotonin reuptake inhibitor.
SGTC_2601 securinine 100 µM 0.825517890311112 0.22281187436865 no 711 0.204538815017712 963 442872 A GABA receptor antagonist.
SGTC_2549 cedrol 20.94 µM 0.824656568775115 0.223049734632531 no 712 0.204783297795586 983 6708665 A sedative which affects the nervous system.
SGTC_946 3434-1334 87.4 µM 0.822376794260629 0.223680008503466 no 713 0.205431241200626 976 4047976
SGTC_3092 9117248 49.47 µM 0.822353783678797 0.223686375241436 no 714 0.205437787325958 1074 17141857
SGTC_1889 st059080 5.18 µM 0.821375490939569 0.223957151806736 no 715 0.205716209803204 1039 176925 Isolated from Daphnopsis sellowiana.
SGTC_262 fenpropimorph 62.5 µM 0.818246374408789 0.224824493152623 no 716 0.206608259937622 945 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2041 5107442 45.335 µM 0.817500535670626 0.225031508509097 no 717 0.206821221645228 1028 793005
SGTC_2186 6124449 200 µM 0.81624188973858 0.225381103711186 no 718 0.207180901347944 1002 3834182 YLR033W RSC58
SGTC_2256 7954252 200 µM 0.815953938554331 0.225461126793247 no 719 0.207263240319787 890 2972920
SGTC_1484 3473-2379 286 µM 0.81573214291615 0.225522775880311 no 720 0.20732667545821 1189 671917
SGTC_3193 9111931 49.47 µM 0.815121024403453 0.225692688348334 no 721 0.207501519101986 1022 17087244
SGTC_2759 disulfiram 3.38 µM 0.814430820668145 0.225884676353045 no 722 0.207699094126017 1002 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1680 diphenhydramine 100 µM 0.813869578953008 0.226040860164827 no 723 0.207859834883612 982 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_811 0416-0114 265 µM 0.813625306080947 0.226108856119224 no 724 0.207929818064798 990 6612453
SGTC_316 k060-0003 58.6 µM 0.812896067404637 0.226311916220391 no 725 0.208138824714405 1003 6152314
SGTC_940 3232-1287 54.8 µM 0.81217592798674 0.226512543639892 no 726 0.208345345056175 1031 1585493 YIL048W NEO1
SGTC_1807 st050092 58.9 µM 0.811635223317976 0.226663247370916 no 727 0.208500486828925 999 5008496
SGTC_2942 9052777 62.25 µM 0.810572460307601 0.226959622635676 no 728 0.208805618727947 1077 6469503
SGTC_1075 aripiprazole 15.2 µM 0.809558962659232 0.227242462624542 no 729 0.209096850922726 1081 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1157 4092-0394 27.6 µM 0.80906966755627 0.227379082821436 no 730 0.209237537199363 1085 3659885
SGTC_2072 5231554 129 µM 0.80849764514755 0.227538860658236 no 731 0.209402080560233 1123 789545
SGTC_405 ebelactone b 50 µM 0.8081396788678 0.227638880290654 no 732 0.209505088979628 1005 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1880 MG-132 525 µM 0.808137867683772 0.227639386417899 no 733 0.209505610241943 978 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_20 0481-0013 4.944 µM 0.808011565377774 0.22767468259276 no 734 0.209541962174947 1052 182045
SGTC_1789 tunicamycin 25 nM 0.807021636869248 0.227951432596223 no 735 0.20982700876733 1041 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_819 1013-0258 27.7 µM 0.806073295627852 0.228216733622107 no 736 0.210100294105144 1030 5753198
SGTC_2026 5148700 152 µM 0.804696090267063 0.228602319444568 no 737 0.210497538148734 1031 79838
SGTC_3001 9076041 71.4286 µM 0.804408368727468 0.228682921037218 no 738 0.210580584795287 1019 16004211
SGTC_682 0kpi-0099 17 µM 0.80317193005607 0.229029475448712 no 739 0.210937683643536 1045 1714895 YML126C ERG13
SGTC_2853 9015042 58.44 µM 0.802422207132379 0.229239754462985 no 740 0.2111543857426 1017 6457456
SGTC_1935 st074532 41.6 µM 0.80231373932136 0.229270186002824 no 741 0.211185748394051 1121 2829742
SGTC_2215 7188065 200 µM 0.801171450735109 0.229590801989169 no 742 0.211516198245978 1038 940217
SGTC_3159 9100096 49.47 µM 0.800833989040808 0.229685568313964 no 743 0.211613879609811 1041 25236875
SGTC_3200 9114385 49.47 µM 0.800225323585759 0.229856549726455 no 744 0.211790130127302 1017 17018030 YLR208W SEC13
SGTC_273 hydroxyurea 18.1 mM 0.799862840776976 0.229958409331881 no 745 0.211895134631592 1105 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1556 plumbagin 1.48 µM 0.799746593997944 0.229991080647126 no 746 0.2119288156023 973 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2146 5545642 200 µM 0.799496165212854 0.230061472823097 no 747 0.212001384678217 1082 825326
SGTC_345 1362-0200 395 µM 0.799382762774523 0.230093352694159 no 748 0.212034251136459 1000 1419823
SGTC_141 0443-0274 32.331 µM 0.796592134069131 0.230878636962485 no 749 0.212843973604481 1187 1627241
SGTC_1429 4049-0205 9.46 µM 0.795132534186078 0.231289964407262 no 750 0.213268205670598 1086 22774478
SGTC_1729 st035615 45.989 µM 0.794189081720241 0.231556054547578 no 751 0.213542681865672 987 17385451
SGTC_1693 xanthone 101.9 µM 0.793880738288474 0.231643056323555 no 752 0.213632432037884 1066 7020 An insecticide.
SGTC_3132 9126706 49.47 µM 0.793001736148711 0.231891174370546 no 753 0.213888405631291 1007 850858
SGTC_2763 lisinopril 49.32 µM 0.792582892863305 0.232009454320231 no 754 0.214010439481449 1013 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_3022 9087993 49.47 µM 0.791723921012844 0.232252130162478 no 755 0.214260835589606 1061 17173644
SGTC_26 0302-0163 425.158 µM 0.791534011486406 0.232305802265256 no 756 0.214316218498268 1074 3100915
SGTC_2024 5144227 134 µM 0.789999870432116 0.232739633122242 no 757 0.214763921997951 1069 3475211
SGTC_1481 3346-2004 36 µM 0.788303242479332 0.233219936557205 no 758 0.215259675749615 1106 2770522
SGTC_975 1335-0046 28.5 µM 0.787015080853148 0.233584973170355 no 759 0.215636519010746 1071 16486740
SGTC_3267 9137951 49.47 µM 0.786770282834279 0.233654379341794 no 760 0.215708176299566 1052 16643986
SGTC_3210 9128157 49.47 µM 0.785306779029776 0.234069556561443 no 761 0.216136861071878 947 17590849
SGTC_2040 5100729 123 µM 0.784811997951409 0.234210011953811 no 762 0.216281902257371 1049 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1744 st037937 38.9 µM 0.781189736450006 0.235239697081011 no 763 0.217345454663176 1073 1016152
SGTC_753 1322-0200 289 µM 0.780804279027039 0.235349416403856 no 764 0.217458808479171 1090 5403907
SGTC_2003 4023581 200 µM 0.779911573791339 0.235603630759988 no 765 0.217721462761173 1057 16641307
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.77990195608636 0.235606370404178 no 766 0.217724293505965 1099 688751
SGTC_1037 k284-1091 78.7 µM 0.77774641642026 0.236220828176738 no 767 0.218359261268773 1032 3334711
SGTC_3204 9114183 49.47 µM 0.777341226154103 0.236336430108629 no 768 0.21847873912096 1035 17027248
SGTC_2977 9011197 71.43 µM 0.776763404795324 0.236501338047449 no 769 0.218649185552669 996 2704722
SGTC_1065 prochlorperazine maleate 2.48 µM 0.776566299038858 0.23655760573539 no 770 0.218707345547224 1131 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_732 3970-1727 52.7 µM 0.774754779438204 0.237075084188087 no 771 0.219242287427855 1079 1275699
SGTC_2154 5570129 200 µM 0.77448838427348 0.237151235025339 no 772 0.219321017323849 1109 673366
SGTC_1128 3448-9350 235 µM 0.774224076726386 0.237226802382194 no 773 0.219399146304259 978 619386
SGTC_884 0851-0618 334 µM 0.773795926345171 0.237349241600517 no 774 0.219525740949779 1091 9642473
SGTC_1777 st045864 34.765 µM 0.773422291109829 0.237456119336679 no 775 0.219636250942952 1077 4691462
SGTC_3340 9146634 11.102 µM 0.770939091211462 0.238167105362607 no 776 0.220371517533901 1082 4907387
SGTC_1073 triclabendazole 3.09 µM 0.77022989369699 0.238370375649599 no 777 0.220581767113175 1106 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_785 1270-0111 65.3 µM 0.76996697868322 0.238445756518665 no 778 0.220659740416521 1105 6741994
SGTC_1165 k072-0275 30.3 µM 0.767256442574954 0.239223659937853 no 779 0.221464530180779 1092 6153523 YGL055W OLE1
SGTC_2155 5570423 76 µM 0.766932078911417 0.239316842672718 no 780 0.221560949825786 1025 797402
SGTC_1984 st072354 53.1 µM 0.766906375550188 0.239324227545765 no 781 0.221568591377502 1066 5762938
SGTC_3151 9099821 49.47 µM 0.76663154666382 0.239403196845162 no 782 0.221650306805257 1079 17174189
SGTC_2430 5571206 200 µM 0.766580117011976 0.239417976215754 no 783 0.22166560040015 1160 1731771
SGTC_171 k064-0041 9.68 µM 0.766468671900855 0.239450003975352 no 784 0.221698742813615 1012 53325
SGTC_1957 st077035 62.4 µM 0.766294117703442 0.239500173101692 no 785 0.221750658787533 1129 705593
SGTC_2873 9040596 71.43 µM 0.766143853583331 0.239543365543138 no 786 0.22179535596009 1110 6463863
SGTC_1091 telmisartan 47.6 µM 0.766106511689608 0.23955409988666 no 787 0.221806464380559 1144 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2480 5767542 37.17 µM 0.766018800541887 0.239579314466395 no 788 0.221832557834432 1098 2867358
SGTC_2012 4023501 200 µM 0.76471029096514 0.239955647507585 no 789 0.222222038425664 1045 3477460
SGTC_2784 7567673 72.73 µM 0.762825428217384 0.240498308394517 no 790 0.222783757028508 1126 3471247
SGTC_1317 1273-0028 910 nM 0.761912211989791 0.240761467796226 no 791 0.223056200467122 1085 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_51 1013-0126 23.419 µM 0.761066564837519 0.241005295642419 no 792 0.223308654858667 1066 1627850
SGTC_1022 4477-0945 21.3 µM 0.760469579369348 0.241177506988037 no 793 0.223486973167019 1067 4648966
SGTC_547 1120-0019 610 nM 0.760316265979084 0.24122174382366 no 794 0.223532780624127 1059 3676939
SGTC_1193 1488-0126 41.5 µM 0.76012448546816 0.241277086117512 no 795 0.223590088926263 1154 1384710
SGTC_727 3032-0951 202 µM 0.759957075957002 0.24132540128733 no 796 0.223640121458847 1069 3652836
SGTC_2291 7917025 104.35 µM 0.759395346958476 0.241487557316294 no 797 0.223808048064473 1074 2964612
SGTC_1640 st009078 66.4 µM 0.758964376480861 0.241612006989759 no 798 0.22393693351412 1048 690618
SGTC_3187 9109394 49.47 µM 0.755785384224424 0.242531067084826 no 799 0.224888940580677 1093 17098090
SGTC_3251 9135047 49.47 µM 0.754599767748312 0.242874317954729 no 800 0.225244581539578 1083 17682963
SGTC_1534 6-azauridine 81.6 µM 0.752553437897727 0.243467374018521 no 801 0.225859153295887 1169 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_151 3013-0144 2.285 µM 0.752262783873605 0.243551673175288 no 802 0.225946521910873 1079 906558 YHR107C CDC12
SGTC_3070 9117005 49.47 µM 0.750245422255048 0.244137208107387 no 803 0.226553453351315 1105 8779016
SGTC_1896 st058441 89 µM 0.748652583347952 0.244600061989748 no 804 0.227033314935418 1040 688759
SGTC_140 0062-0056 502.533 µM 0.748399854338313 0.244673544474744 no 805 0.227109505186962 1140 3758964
SGTC_471 1-acyl-paf 4 µM 0.745584590828879 0.245492902462278 no 806 0.227959197055157 1100 16759367
SGTC_1093 fluphenazine 7.97 µM 0.744608775583034 0.245777248674069 no 807 0.228254130637588 1186 6602611 An atypical antipsychotic.
SGTC_408 cantharidin 100 µM 0.744340951924691 0.245855321657179 no 808 0.228335116032344 1083 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2267 7931562 200 µM 0.743614209064341 0.246067240727206 no 809 0.228554952260605 1066 934880
SGTC_3109 9122853 49.47 µM 0.743560660643827 0.246082859384467 no 810 0.228571155102153 1158 1234709
SGTC_1156 4092-0367 4.88 µM 0.742576634982529 0.246369968280214 no 811 0.228869019373155 1129 1357585
SGTC_1661 st013063 9.66 µM 0.742256267194809 0.246463480628007 no 812 0.228966041595042 1164 721395
SGTC_3244 9134489 49.47 µM 0.742186343121923 0.24648389333633 no 813 0.228987220914623 1111 16584271
SGTC_2593 nobiletin 86.24 µM 0.740171593400768 0.247072441587697 no 814 0.229597940871191 1083 72344 An anti-infammatory.
SGTC_3239 9133757 49.47 µM 0.739856697817692 0.247164496701313 no 815 0.229693475816369 1128 17036923
SGTC_1488 4013-0813 75.9 µM 0.739292009437382 0.247329621012246 no 816 0.229864850173772 1085 2910057
SGTC_1726 st035556 14.5795 µM 0.737630375058913 0.247815852524178 no 817 0.230369545993481 1138 5919439
SGTC_1020 4335-0961 93.3 µM 0.736396661847582 0.248177194532848 no 818 0.2307446677834 1039 669075
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.736045996220418 0.248279952177678 no 819 0.230851353115691 1157 688788
SGTC_567 1080-0542 68.4 µM 0.735812206530821 0.248348473569412 no 820 0.23092249580675 1083 5950415
SGTC_1395 3486-0190 4.35 µM 0.735675617267214 0.24838851116489 no 821 0.230964065869436 1178 6748079
SGTC_420 mitomycin C 81.9 mM 0.735651665468788 0.248395532367113 no 822 0.23097135587553 1119 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2161 5662504 8.5105 µM 0.73509395579809 0.248559048632813 no 823 0.231141137559382 1085 2859334
SGTC_457 grayanotoxin iii 135 µM 0.734882852507729 0.248620957482407 no 824 0.231205421190624 1122 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_3145 9085516 49.47 µM 0.734550087271959 0.248718561992384 no 825 0.231306772679454 1147 25236195
SGTC_500 h-89 112 µM 0.734382906411082 0.248767606082639 no 826 0.231357700898643 1154 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1173 0443-0020 122 µM 0.733863498501814 0.248920012161452 no 827 0.231515967751458 1138 5331295
SGTC_1394 3474-0001 65.7 µM 0.733326006700701 0.2490777767696 no 828 0.231679808406001 1054 5017666 YIL048W NEO1
SGTC_237 nikkomycin 200 µM 0.731920579644621 0.249490549023956 no 829 0.232108522167622 1154 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2348 9022543 33.42 µM 0.730787780731693 0.249823515094445 no 830 0.232454394158068 1131 3162678 YDL140C RPO21
SGTC_538 2922-0838 53.3 µM 0.730316630258628 0.249962070820193 no 831 0.232598332599586 1192 777039
SGTC_684 1140-0066 328 µM 0.73026037408009 0.249978617337574 no 832 0.232615522408346 1162 6813534
SGTC_1464 k208-0027 110 µM 0.728579511228577 0.250473274185067 no 833 0.233129457629165 1133 X1464
SGTC_2965 9082772 38.63 µM 0.728276235903413 0.250562579514016 no 834 0.233222253202576 1168 16459634
SGTC_903 1134-0042 114 µM 0.727880356422639 0.250679179318819 no 835 0.23334341445033 1156 701009
SGTC_957 1187-1561 14.1 µM 0.72677353488046 0.251005327871539 no 836 0.23368234896309 1153 1538454
SGTC_3350 9150499 3.57 µM 0.725878587978693 0.251269207131692 no 837 0.233956601970806 1151 4910996 YPR165W RHO1
SGTC_2798 7813637 45.45 µM 0.725478150647272 0.251387325424816 no 838 0.234079372155944 1122 956368
SGTC_2756 carbadox 75.1 µM 0.725408049110683 0.251408006519835 no 839 0.234100868273389 1143 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1734 st037168 69.4 µM 0.723790857182642 0.251885354032259 no 840 0.23459707160115 1081 708907
SGTC_1500 4488-1866 171 µM 0.722794438158774 0.252179705646436 no 841 0.234903092438573 1197 2900003
SGTC_841 0251-0215 91.2 µM 0.722535774005637 0.252256147135223 no 842 0.234982569588012 1182 3888614
SGTC_1873 rapamycin 2 nM 0.722414737552185 0.252291920518819 no 843 0.235019764351589 1144 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3134 9127454 49.47 µM 0.720116130858847 0.252971801267499 no 844 0.235726748242662 1239 24262820
SGTC_2199 6590217 200 µM 0.719180284266488 0.253248881424631 no 845 0.236014922755469 1108 703109
SGTC_1886 st057356 49.9 µM 0.718963052952826 0.253313220853337 no 846 0.236081842374348 1138 24207747
SGTC_2497 7-hydroxyflavone 100 µM 0.718369775277374 0.253488981220655 no 847 0.236264658943742 1101 5281894
SGTC_225 nsc-122657 1.016 µM 0.717925376781188 0.2536206776296 no 848 0.236401649934966 1080 275685
SGTC_92 0063-0024 660.874 µM 0.717556602618156 0.253729990231155 no 849 0.236515362036874 1220 3594437
SGTC_878 0828-0289 13.7 µM 0.717108640617992 0.253862809083532 no 850 0.236653532315204 1133 745350 YLR208W SEC13
SGTC_858 0438-0351 2.77 µM 0.717088412823591 0.25386880740068 no 851 0.236659772463437 1159 2799119
SGTC_3203 9113543 49.47 µM 0.716738975278067 0.253972440782055 no 852 0.236767586050602 1156 17018012
SGTC_3084 9116877 49.47 µM 0.716666143404401 0.253994043469549 no 853 0.236790060607658 1082 27241325
SGTC_857 0438-0306 1.35 µM 0.716076519943758 0.254168967381448 no 854 0.236972050590856 1163 4686136
SGTC_2206 7254556 146.969 µM 0.715172196767157 0.254437376135976 no 855 0.23725132340479 1168 4398905
SGTC_2761 levamisole 97.89 µM 0.71328008723375 0.254999446184919 no 856 0.237836228464881 1149 26879 An alkaline phosphatase inhibitor.
SGTC_376 3970-0862 59.1 µM 0.712845568825916 0.255128615882996 no 857 0.237970662075244 1155 3135186
SGTC_105 0111-0055 734.78 µM 0.712616713066744 0.255196661806608 no 858 0.238041483428761 1092 5179370
SGTC_1612 st002233 45.4 µM 0.710614908364162 0.255792264807861 no 859 0.238661451052753 1208 1035021
SGTC_2512 diallyl trisulfide 49.23 µM 0.709789496048899 0.256038063347276 no 860 0.238917341882259 1181 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.70952184523756 0.256117793205614 no 861 0.239000350054862 1049 6708630 An antioxidant.
SGTC_2721 ifenprodil 61.44 µM 0.708414297388279 0.256447855575682 no 862 0.239344008160456 1174 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2132 5317594 122.667 µM 0.70669801633952 0.25695976511385 no 863 0.239877081278012 1151 794577
SGTC_1636 st007707 68.9 µM 0.706577248474251 0.256995806160229 no 864 0.239914615883815 1196 403051
SGTC_1104 tacrolimus 29.8 µM 0.705497950163644 0.257318020496465 no 865 0.240250203573762 1225 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2990 9074105 71.4286 µM 0.704413746825443 0.25764191044814 no 866 0.240587573763649 1148 6502001
SGTC_2540 epiandrosterone 100 µM 0.703450159112213 0.257929945808125 no 867 0.240887628487191 1272 441302 A steroid.
SGTC_1779 st039427 55 µM 0.702173007481566 0.258311968896755 no 868 0.241285638419418 1236 1124498
SGTC_2726 cimetidine 79.27 µM 0.700669784185824 0.258761990188767 no 869 0.24175455851269 1191 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_66 0109-0187 42.4 µM 0.700341594250796 0.258860294637773 no 870 0.241857000828255 1168 759417
SGTC_1820 st053765 18.6 µM 0.699689766634596 0.259055597260552 no 871 0.242060534329369 1178 3690829
SGTC_396 dithiazanine 1.25 µM 0.697237969869199 0.259790893985845 no 872 0.242826940179029 1177 10578 An antihelmenthic.
SGTC_2832 7992762 51.95 µM 0.696689887904195 0.259955411562383 no 873 0.242998444240472 1104 2985177
SGTC_346 4513-0042 7.16 µM 0.696365849148196 0.260052703434236 no 874 0.243099872227032 1189 2827372
SGTC_2420 aureobasidin a 50 nM 0.696365787679299 0.260052721891907 no 875 0.243099891469699 1238 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2987 9018338 71.43 µM 0.696170003960813 0.260111514590897 no 876 0.243161185199306 1232 5055682
SGTC_1189 1431-2119 7.28 µM 0.696156293707663 0.260115631955975 no 877 0.243165477761745 1224 3107275
SGTC_1389 3405-0187 19 µM 0.696047422007816 0.26014832871816 no 878 0.24319956600975 1146 799890
SGTC_2544 sphondin 68.51 µM 0.69452316292122 0.260606322353733 no 879 0.243677089963677 1218 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1262 0737-0114 49.6 µM 0.693832789631735 0.260813895076059 no 880 0.243893538405632 1231 765919
SGTC_1148 3909-7663 27.7 µM 0.693181711222725 0.261009731011965 no 881 0.244097761987521 1252 4084526
SGTC_1917 st066507 28.5 µM 0.693000123389377 0.261064363756267 no 882 0.244154737035839 1184 3156428
SGTC_935 2996-0153 430 µM 0.692586207067837 0.26118891711048 no 883 0.244284634332132 1207 23738523
SGTC_1871 st057448 67.3 µM 0.692269559258502 0.261284221587146 no 884 0.244384031480283 1282 691747
SGTC_2956 9076196 2.52 µM 0.691709110100246 0.261452949037876 no 885 0.244560012363469 1237 16423868
SGTC_137 0438-0332 85.389 µM 0.691474590631914 0.261523569494878 no 886 0.244633671664872 1237 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_34 0469-0683 81.75 µM 0.688925463908872 0.262291814995694 no 887 0.245435087056665 1203 3690923
SGTC_390 dec-rvkr-cmk 16.7 µM 0.686986095139505 0.262877067402049 no 888 0.246045745401767 1246 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1978 st071761 42 µM 0.68672477091494 0.262955979456688 no 889 0.246128092082456 1169 5147680
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.685624835790679 0.263288259477806 no 890 0.246474858008927 1195 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_3158 9100007 49.47 µM 0.684848338059474 0.263522961168862 no 891 0.246719814494338 1215 19297233
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.684520164322922 0.263622185989311 no 892 0.246823380418178 1263 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1480 1070-0044 41.2 µM 0.681083517884856 0.264662415375234 no 893 0.24790932278431 1213 3124987
SGTC_3332 9141069 11.198 µM 0.680216170371432 0.264925280034256 no 894 0.248183797477456 1185 17332883
SGTC_2147 5545932 89.7195 µM 0.679035379863021 0.26528335215605 no 895 0.24855772248173 1227 797404
SGTC_728 3030-5151 22.5 µM 0.678441116375443 0.265463654144761 no 896 0.248746023427235 1235 3125388
SGTC_1143 3454-2408 5.08 µM 0.677583538221511 0.265723956447074 no 897 0.249017893263538 1186 X1143
SGTC_967 1306-0166 352 µM 0.677035729516822 0.265890301553948 no 898 0.249191642560284 1209 4437607
SGTC_2630 antimycin a 100 µM 0.67555239182166 0.266340989880877 no 899 0.249662438436311 1235 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_823 0417-1665 178 µM 0.674490759476595 0.266663786989758 no 900 0.249999679274407 1249 3429856
SGTC_2979 9012552 45.46 µM 0.674184857898305 0.266756835301727 no 901 0.250096897590919 1285 17100905
SGTC_2129 girgensonine 121.053 µM 0.673406174460591 0.266993767142679 no 902 0.250344460777167 1264 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1046 2001-0062 216 µM 0.672719262311038 0.267202863712351 no 903 0.250562955345028 1188 739778
SGTC_1770 st043884 66.3 µM 0.668259362314794 0.268562467848915 no 904 0.251984024330475 1236 670149
SGTC_2109 5483026 200 µM 0.667728835120184 0.268724430609889 no 905 0.252153350122275 1264 759335
SGTC_693 4161-2696 114 µM 0.66769210920182 0.268735644350687 no 906 0.252165073976135 1253 805759
SGTC_1689 st020265 53.493 µM 0.667265953718874 0.268865782099828 no 907 0.252301134742438 1240 5758320 YPR016C TIF6
SGTC_1626 st003712 1.76 µM 0.662737264255263 0.270250688255095 no 908 0.253749419624235 1228 24207035
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.661804212633462 0.270536464745974 no 909 0.254048352995231 1220 5355888
SGTC_1952 st077036 64.1 µM 0.661338692915808 0.270679101273793 no 910 0.254197566399098 1259 2937007
SGTC_274 sirtinol 40.1 µM 0.660463165986464 0.270947466836848 no 911 0.254478324188891 1241 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_205 1486-1330 71.903 µM 0.659335654946428 0.271293265750297 no 912 0.254840125676217 1245 4118834
SGTC_1683 st010134 710 nM 0.658493692509925 0.271551632495066 no 913 0.255110474368171 1265 3818134
SGTC_2790 5423970 71.43 µM 0.657677745430487 0.271802132964506 no 914 0.255372612751127 1287 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1333 1482-0047 286 µM 0.656947684308217 0.272026363379319 no 915 0.255607277926234 1232 3811116
SGTC_2117 5521686 200 µM 0.654856333864932 0.272669207911991 no 916 0.256280128262267 1255 803312
SGTC_731 3966-0296 387 µM 0.654649254166381 0.272732901585848 no 917 0.256346802230238 1283 660956
SGTC_3275 9138069 49.47 µM 0.654236623090191 0.272859840859001 no 918 0.256479685038452 1281 17617007
SGTC_809 3998-0021 90 µM 0.653587394186172 0.27305962493114 no 919 0.256688833921281 1207 715485
SGTC_1757 st041620 31.8375 µM 0.653358320159624 0.273130134074971 no 920 0.256762651233673 1261 5289815
SGTC_921 1561-0023 372 µM 0.653303932642882 0.273146875915543 no 921 0.256780178808449 1256 24050882
SGTC_2255 7941087 197.44 µM 0.652722285911224 0.273325953148727 no 922 0.256967666213749 1290 935561
SGTC_2722 naftopidil 47.16 µM 0.6525094248178 0.273391503292904 no 923 0.257036297434748 1252 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2974 9094440 9.66 µM 0.652190510317222 0.273489726935218 no 924 0.257139140508215 1339 25236134
SGTC_1229 0139-0193 12.2 µM 0.651667441750987 0.273650866546438 no 925 0.257307865196407 1303 3090752
SGTC_964 1287-0107 19.4 µM 0.650688691941905 0.273952512154582 no 926 0.257623732139476 1295 51516812 YPR165W RHO1
SGTC_2897 9048598 12.99 µM 0.650552625892614 0.273994460012981 no 927 0.257667659978694 1251 6467404
SGTC_2845 9003024 42.97 µM 0.650239392248176 0.274091039005984 no 928 0.257768799742472 1323 2990173
SGTC_2775 cyproheptadine 69.59 µM 0.649858851120169 0.274208393467499 no 929 0.257891700083799 1271 2913 A selective serotonin reuptake inhibitor.
SGTC_2864 9034755 47.6 µM 0.649509754309112 0.27431607268745 no 930 0.258004471837424 1259 4930451
SGTC_2705 st078069 42.8 µM 0.645962702218981 0.275411346261848 no 931 0.259151755267498 1254 1530061
SGTC_1150 3909-7983 10.9 µM 0.645342475811168 0.275603083139612 no 932 0.259352636210636 1257 23965914
SGTC_876 0720-0963 56.8 µM 0.645337857771356 0.275604511007215 no 933 0.259354132218047 1297 765861
SGTC_762 1165-0429 115 µM 0.644863472119018 0.275751207313215 no 934 0.25950783252241 1289 5967793
SGTC_1018 4259-0013 28.1 µM 0.644426818431538 0.275886269512005 no 935 0.259649349286506 1278 6801262
SGTC_923 1900-2434 73.3 µM 0.644202382474363 0.275955702875793 no 936 0.259722103091803 1250 5910570
SGTC_801 0866-0028 10.1 µM 0.644157584440404 0.275969562993534 no 937 0.259736626210822 1295 6849771
SGTC_1353 1498-1206 8.11 µM 0.644112615985402 0.275983476181889 no 938 0.259751205000302 1310 6756808
SGTC_1754 st042065 16.137 µM 0.641744549271435 0.276716639641217 no 939 0.260519529306167 1226 1126236 YIL048W NEO1
SGTC_1792 st045773 43.6 µM 0.641397943860315 0.276824030147964 no 940 0.260632084264492 1236 2919270
SGTC_3117 9124945 49.47 µM 0.641371487398034 0.276832228125889 no 941 0.260640676635687 1195 17592065
SGTC_1837 st055472 66.5 µM 0.640390992889509 0.277136134606117 no 942 0.26095921856296 1330 676091
SGTC_2940 9060638 45.86 µM 0.639514718837257 0.277407875790189 no 943 0.261244070779148 1293 4027022
SGTC_2408 sulbentine 18.36 µM 0.637909449834998 0.277906023105355 no 944 0.261766312978685 1315 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2976 9009005 19.48 µM 0.637519496884996 0.278027099244465 no 945 0.261893257186208 1303 2993148
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.636350325121865 0.278390268516866 no 946 0.262274055271534 1296 3256 An antibiotic and ribosome inhibitor.
SGTC_2515 chrysin 20.77 µM 0.63543881771388 0.278673562119598 no 947 0.262571128959164 1289 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.632924559267075 0.279455712426934 no 948 0.263391454521922 1269 6857784
SGTC_2000 st075254 36.4 µM 0.632016128550445 0.279738574362946 no 949 0.263688169112372 1279 17234175
SGTC_1345 1488-0192 31.4 µM 0.63056456375519 0.280190842401611 no 950 0.264162637544006 1300 658348
SGTC_2770 toltrazuril 17.5 µM 0.630337968349899 0.280261475310815 no 951 0.264236743294791 1286 68591 Kills coccidiodes.
SGTC_207 4185-0010 4.486 µM 0.629234649164029 0.280605518284188 no 952 0.264597723959303 1342 3761753
SGTC_67 0335-0847 266 µM 0.624297522228848 0.282147538125271 no 953 0.26621610542892 1432 4552207 YOR254C SEC63
SGTC_1773 st048542 73.5835 µM 0.623922404422151 0.282264865745642 no 954 0.266339272898164 1240 3237138
SGTC_76 0433-0009 400.328 µM 0.622469171912887 0.282719622648532 no 955 0.266816704347821 1313 2841569
SGTC_2043 5101342 149 µM 0.622307960273601 0.282770091942199 no 956 0.266869693951325 1291 678451
SGTC_720 r052-1644 49.9 µM 0.621837005716064 0.282917554866252 no 957 0.267024525227409 1284 1422863 YOR257W CDC31
SGTC_996 3970-0799 1.8 µM 0.619978902186178 0.283499714872212 no 958 0.267635838576323 1401 6615648 YGL040C HEM2
SGTC_1371 2421-0008 32.7 µM 0.619343501550553 0.283698923066265 no 959 0.267845046200522 1313 2827552
SGTC_2429 5902844 64.44 µM 0.619100728123118 0.28377505408975 no 960 0.26792500184705 1337 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_680 0417-1641 114 µM 0.617439524223143 0.284296251299657 no 961 0.268472429482765 1301 2835990
SGTC_953 1188-0045 9.7 µM 0.616658926829795 0.284541319057969 no 962 0.268729859033466 1341 6144426
SGTC_622 1348-1566 26.3 µM 0.615788957280728 0.284814563937425 no 963 0.269016908249018 1365 7340407
SGTC_2762 leflunomide 42.06 µM 0.615767606158466 0.284821271590593 no 964 0.269023955054027 1326 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_483 fpl-64176 144 µM 0.615236170390559 0.284988251349917 no 965 0.269199381968099 1339 3423
SGTC_3163 9099914 49.47 µM 0.61491846117942 0.28508809945478 no 966 0.269304285160321 1350 16268368
SGTC_2679 rapamycin 1 nM 0.614664943501326 0.285167785718196 no 967 0.269388007898478 1295 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2457 5731572 11.68 µM 0.614293280424506 0.285284626901821 no 968 0.269510771051037 1353 2865357
SGTC_1920 st075728 45.7 µM 0.6129919717419 0.285693904056967 no 969 0.269940824070666 1390 3400306
SGTC_415 dibenzyl ketone 100 µM 0.611189406781289 0.286261293346287 no 970 0.270537097767109 1400 7593
SGTC_1273 0849-0096 14.1 µM 0.608383264790348 0.287145639647444 no 971 0.271466654122429 1322 5286025
SGTC_880 0833-0487 87.2 µM 0.608290828258357 0.287174792703862 no 972 0.271497301489446 1293 76075
SGTC_874 0599-0792 117 µM 0.606678267523622 0.287683594768306 no 973 0.272032223720268 1340 765305
SGTC_522 1273-0010 11.6 µM 0.606139703712646 0.287853619573272 no 974 0.272210993980203 1383 5705015
SGTC_1225 1216-0074 20.6 µM 0.602268114698961 0.289077276398403 no 975 0.273497840810967 1319 4241466
SGTC_2217 6934799 96.0675 µM 0.600045342540824 0.289780910846615 no 976 0.274238008705444 1292 675606
SGTC_2411 st077133 39.94 µM 0.597910885845633 0.290457343761044 no 977 0.274949697957491 1482 1403142 YNL221C POP1
SGTC_2785 7756463 72.73 µM 0.596068425335467 0.291041833544885 no 978 0.275564758214823 1305 2201551
SGTC_783 0848-0141 92.7 µM 0.59549545014391 0.291223712279426 no 979 0.275756169764315 1338 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.595482635270519 0.29122778069381 no 980 0.2757604515252 1340 442882
SGTC_2151 5563267 85.4165 µM 0.594115180701368 0.291662067059031 no 981 0.276217539033996 1346 5310824
SGTC_158 k038-0087 26.446 µM 0.59373124722431 0.29178405375518 no 982 0.276345940058667 1303 X158
SGTC_550 4123-0385 25.7 µM 0.592186063133981 0.292275243334805 no 983 0.276863000488619 1331 5731123
SGTC_3080 9117754 49.47 µM 0.591094190487703 0.292622564121234 no 984 0.277228656100725 1467 9550191
SGTC_1238 0333-0287 48.8 µM 0.590652571882007 0.292763095861147 no 985 0.277376616166535 1344 7226
SGTC_3323 9138564 53.9225 µM 0.590276649629812 0.292882746414071 no 986 0.277502595715077 1388 43912313 YNL103W MET4
SGTC_708 3448-5400 146 µM 0.59025713575304 0.292888958015181 no 987 0.277509135993953 1336 3462195
SGTC_3276 9139060 49.47 µM 0.589502721610688 0.293129147816918 no 988 0.277762043482473 1397 4870619
SGTC_893 0958-0369 48.9 µM 0.589029455822074 0.293279872430409 no 989 0.27792075708732 1418 6819948
SGTC_1732 st034308 51.822 µM 0.587031029829596 0.293916722352432 no 990 0.278591433464017 1345 830119
SGTC_115 0527-0192 112.043 µM 0.586828716215499 0.293981230431426 no 991 0.278659374293128 1374 4233931
SGTC_1453 4237-0541 195 µM 0.586821793608453 0.293983437833615 no 992 0.278661699181362 1334 739892
SGTC_2699 st077704 54.6 µM 0.586242471858543 0.294168192512133 no 993 0.278856292047274 1379 645852
SGTC_1107 amlodipine 47 µM 0.585618201563424 0.294367342011034 no 994 0.27906605701785 1273 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2714 st079313 56.9 µM 0.583454301664071 0.295058132694098 no 995 0.279793755948091 1364 2939799
SGTC_661 1304-0007 33.6 µM 0.578830801229133 0.296536608197796 no 996 0.281351672885562 1361 3117130
SGTC_2636 apigenin dimethyl ether 100 µM 0.577464921508884 0.296974029713831 no 997 0.281812714322552 1376 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_599 1935-0052 86.5 µM 0.577275126144883 0.297034834825824 no 998 0.28187680698287 1344 9557311
SGTC_2398 5228213 48.84 µM 0.575304699735223 0.297666440320059 no 999 0.282542621798179 1422 80771 YMR134W ERG29
SGTC_632 0781-2353 4.65 µM 0.575281461157152 0.297673892928251 no 1000 0.282550478714062 1411 6811515 YHR007C ERG11
SGTC_1813 st051246 8.6015 µM 0.573560725295607 0.29822596903281 no 1001 0.283132547653148 1355 5291959
SGTC_506 n9-isopropylolomoucine 153 µM 0.572821834632578 0.29846317567165 no 1002 0.283382666773856 1414 6610355
SGTC_2664 lyso-paf C-16 73.48 µM 0.571830319556722 0.298781617339262 no 1003 0.283718467203105 1378 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1749 st037932 54.2 µM 0.569168264597576 0.299637343701112 no 1004 0.284620977582673 1373 594497
SGTC_251 melphalan 456.522 µM 0.566781403319215 0.300405550931213 no 1005 0.285431353397641 1468 460612 A DNA alkylator.
SGTC_2939 9044578 71.43 µM 0.566595235160441 0.300465506226697 no 1006 0.285494606487944 1354 2653634
SGTC_2023 5144124 124 µM 0.566323886135436 0.300552903625837 no 1007 0.285586812852232 1372 2830192
SGTC_2482 5981709 142.65 µM 0.565345834843515 0.300868014301216 no 1008 0.28591927932107 1408 877755
SGTC_1397 3532-0190 20.1 µM 0.565277534640988 0.300890024972981 no 1009 0.285942503305308 1384 5322280
SGTC_2391 6285546 200 µM 0.565257628903606 0.300896440004998 no 1010 0.285949271982994 1351 846083
SGTC_2616 abietic acid 100 µM 0.563133207908972 0.301581432468333 no 1011 0.286672090137016 1409 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_414 piperonyl butoxide 100 µM 0.562274303577727 0.301858574216006 no 1012 0.286964571582661 1358 5794 A potent inhibitor of cytochrome P450.
SGTC_2114 5491910 81.25 µM 0.562029177085085 0.301937689908583 no 1013 0.287048070072782 1465 2849228
SGTC_1893 st059353 36.1 µM 0.558545858623994 0.303062952005275 no 1014 0.288235849443487 1359 3112488
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.557406677339678 0.303431363390805 no 1015 0.288624802159463 1380 16486 A toxic proline analog.
SGTC_658 3253-0951 102 µM 0.556514253076166 0.303720113210223 no 1016 0.288929676781025 1426 1184878
SGTC_2685 mycophenolic acid 18.85 µM 0.556477317614522 0.303732066567349 no 1017 0.288942298130677 1416 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_609 0986-0026 86.3 µM 0.555179691794252 0.304152148053826 no 1018 0.289385879092288 1443 2848610
SGTC_909 3448-9333 149 µM 0.554783526356671 0.304280450582567 no 1019 0.289521368174737 1373 3344074
SGTC_3169 9102970 49.47 µM 0.554483005383547 0.304377793674753 no 1020 0.289624166594404 1448 17027839
SGTC_3046 9092212 49.47 µM 0.551981230964625 0.305188692081219 no 1021 0.290480606304436 1439 25236637
SGTC_2970 9090938 41.86 µM 0.551083804495561 0.305479807779114 no 1022 0.290788113526321 1473 17217104
SGTC_2866 9034245 58.44 µM 0.550395650447002 0.305703121065756 no 1023 0.29102401566443 1423 6462273
SGTC_1558 st069300 45.6 µM 0.549511813596434 0.305990041523741 no 1024 0.291327129787331 1428 24208000
SGTC_1245 0418-0076 17.2 µM 0.547916892063705 0.306508103068789 no 1025 0.291874484734791 1445 6790114
SGTC_925 2064-1272 59.6 µM 0.547362919630183 0.306688134683322 no 1026 0.292064712411098 1395 6815817
SGTC_1575 cyproterone acetate 48 µM 0.547300206372821 0.306708518364952 no 1027 0.292086251048553 1347 9880 An androgen receptor antagonist and liver toxin.
SGTC_216 k038-0035 28.382 µM 0.54702909966132 0.306796643020329 no 1028 0.292179370155971 1378 4444231 YPR107C YTH1
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.546582215035888 0.306941929580472 no 1029 0.292332895198948 1385 688803
SGTC_1016 4226-1401 38 µM 0.546306052806557 0.307031727782385 no 1030 0.292427788142795 1402 2901613
SGTC_177 1327-0068 8.361 µM 0.543324575231444 0.308001935203725 no 1031 0.293453173347401 1399 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_518 1021-0119 62.6 µM 0.543025317079308 0.308099391581104 no 1032 0.293556185661873 1366 1097762
SGTC_2528 xanthyletin 44.79 µM 0.54282375239657 0.308165040741192 no 1033 0.293625578819988 1456 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_183 3914-0051 30.55 µM 0.542530186467965 0.30826066547691 no 1034 0.293726659050267 1513 1596232
SGTC_1721 st082152 9.2685 µM 0.542194154795396 0.308370138770486 no 1035 0.293842380790758 1359 5296051
SGTC_1202 1988-0068 29.6 µM 0.542043630184384 0.308419182606873 no 1036 0.293894224915645 1357 2850480
SGTC_3247 9135149 49.47 µM 0.541367459993154 0.308639534129543 no 1037 0.294127165591498 1400 8934436 YOR116C RPO31
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.540024039125979 0.309077534923391 no 1038 0.294590227146123 1415 15053
SGTC_2880 9042983 58.44 µM 0.539859987221492 0.309131040028821 no 1039 0.294646796967158 1416 6464714
SGTC_1954 st077032 68.9 µM 0.53903847982028 0.309399033433007 no 1040 0.29493015171991 1336 698907
SGTC_2324 6149169 200 µM 0.53882089456731 0.309470031420241 no 1041 0.295005222364866 1383 2888231
SGTC_1520 flindersine 88 µM 0.538755765587236 0.309491284365396 no 1042 0.295027694691996 1566 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2597 laccaic acid a 100 µM 0.538186155598395 0.30967718713852 no 1043 0.295224268478768 1442 5491415 A textile dye.
SGTC_1126 isoteolin 1.0172 µM 0.538118613784683 0.309699233891108 no 1044 0.29524758132014 1379 133323
SGTC_381 3461-2219 42.7 µM 0.536770967491942 0.310139270707418 no 1045 0.295712914108924 1486 2883159
SGTC_2249 haloperidol 116.36 µM 0.534882639541433 0.310756309789368 no 1046 0.296365506818938 1456 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1856 st057054 55.7 µM 0.534093620627382 0.311014291265488 no 1047 0.296638381585776 1549 1266018
SGTC_1662 st014054 52 µM 0.533498820670107 0.311208831383105 no 1048 0.29684416359409 1418 2838777
SGTC_3257 9139206 32.98 µM 0.533471035611934 0.311217920280454 no 1049 0.296853777944175 1414 4910041
SGTC_672 1441-0018 53.7 µM 0.533420537676286 0.31123443918564 no 1050 0.296871251903258 1387 251141
SGTC_1296 1068-0102 11.9 µM 0.533374019861862 0.311249656448363 no 1051 0.296887349025018 1469 767053
SGTC_502 l-744,832 89.3 µM 0.533228333381341 0.31129731660958 no 1052 0.296937765263371 1472 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2641 levomentholum 100 µM 0.532664442742801 0.311481818712005 no 1053 0.297132942072345 1403 16666
SGTC_2095 5432005 200 µM 0.532640421844178 0.311489679277713 no 1054 0.297141257615122 1430 783734
SGTC_108 0509-0257 621.132 µM 0.532000260369854 0.311699196484568 no 1055 0.297362907586031 1399 536624
SGTC_2355 9061122 103.12 µM 0.531674932836826 0.311805695671439 no 1056 0.29747557816354 1487 5302957
SGTC_3238 9133470 49.47 µM 0.530840599054679 0.312078895016142 no 1057 0.297764621774508 1512 3534688
SGTC_462 ag-879 158 µM 0.530387269563028 0.312227379351706 no 1058 0.297921725318326 1505 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1396 3511-0007 98.6 µM 0.524747635858278 0.314077138829582 no 1059 0.299879318831092 1420 X1396
SGTC_2713 st079149 53.4 µM 0.520374985523344 0.315514561679818 no 1060 0.301401120642696 1480 3103253
SGTC_386 1509-0011 3.07 µM 0.520069352347357 0.315615137370469 no 1061 0.301507619208986 1444 3107280
SGTC_3152 9099253 49.47 µM 0.518809846421057 0.316029751082141 no 1062 0.301946675429966 1468 25236131
SGTC_2004 4023728 41.89 µM 0.518041128560624 0.316282917257781 no 1063 0.302214786937384 1474 360084 YDR527W RBA50
SGTC_61 0978-8327 98.565 µM 0.517532436328039 0.316450495101035 no 1064 0.302392266074642 1463 6150059 YHR072W ERG7
SGTC_10 0279-0212 42.575 µM 0.516053045698895 0.316938063007785 no 1065 0.302908680491342 1444 39851 YBR002C RER2
SGTC_1024 4507-0395 26 µM 0.515379024089621 0.317160308171966 no 1066 0.303144093654192 1489 4201836
SGTC_1177 0983-0204 23.6 µM 0.515278688068611 0.317193397613212 no 1067 0.303179144660185 1494 766818
SGTC_3338 9144300 39.5675 µM 0.514913735295704 0.317313766348053 no 1068 0.303306651162901 1484 4901274
SGTC_1220 1838-0075 193 µM 0.514483473594141 0.317455700097061 no 1069 0.303457005952651 1456 5529645
SGTC_806 3966-4455 5.86 µM 0.51443764384444 0.317470819892591 no 1070 0.30347302310341 1398 714982
SGTC_1248 0469-0687 58.6 µM 0.514054129062702 0.317597358049582 no 1071 0.303607073417904 1522 4017482
SGTC_2280 7785178 200 µM 0.51180857129372 0.318338692275776 no 1072 0.304392495490766 1497 2954328
SGTC_213 1246-0773 967 nM 0.50904219152009 0.319252968258351 no 1073 0.305361325337273 1481 6251622
SGTC_511 blebbistatin 171 µM 0.508293142991727 0.319500714933343 no 1074 0.305623889064748 1538 3476986 A myosin inhibitor.
SGTC_3154 9100113 49.47 µM 0.508082458575817 0.319570413013203 no 1075 0.305697758223234 1415 25237525
SGTC_73 0327-0325 16.231 µM 0.50739776695711 0.319796964948438 no 1076 0.305937876107327 1490 53298
SGTC_1724 st037281 8.293 µM 0.507228735424815 0.319852904743714 no 1077 0.305997167454406 1456 574124 YDL195W SEC31
SGTC_531 3788-1495 174 µM 0.505980471615871 0.320266135641917 no 1078 0.306435179415459 1463 2896655
SGTC_747 3448-8087 38.7 µM 0.503751610206574 0.321004542341974 no 1079 0.307217967965278 1464 5168703
SGTC_1852 st056254 31.4 µM 0.50366018605171 0.321034845690727 no 1080 0.307250095433452 1512 442583
SGTC_1493 4348-0038 111 µM 0.503579488041673 0.32106159475387 no 1081 0.307278454843882 1511 800424
SGTC_648 0375-0473 33.3 µM 0.503452085153093 0.321103827027578 no 1082 0.307323229927203 1499 1713139
SGTC_805 3852-0218 479 µM 0.50268666677176 0.32135760120066 no 1083 0.307592292681051 1424 6615355
SGTC_2305 7443522 69.23 µM 0.502401931673026 0.321452026308647 no 1084 0.307692410266314 1514 5415886
SGTC_3056 9094900 49.47 µM 0.50233228232563 0.32147512548885 no 1085 0.307716902313053 1405 25236784
SGTC_983 1491-0821 12.2 µM 0.501973913083453 0.321593989428058 no 1086 0.307842935650344 1538 46495113
SGTC_371 0195-0006 7.36 µM 0.497733300793417 0.323001900202332 no 1087 0.309336016631109 1395 3928593
SGTC_919 tnp00227 403.569 nM 0.497505617258643 0.323077564633519 no 1088 0.309416271349913 1512 1269246 A methoxyflavone. YNL221C POP1
SGTC_877 0771-0151 33.1 µM 0.495955600539795 0.323592864985458 no 1089 0.309962868324597 1528 6166523
SGTC_734 2023-0417 80 µM 0.495616187755254 0.323705747376882 no 1090 0.310082614782518 1518 3935732
SGTC_1228 0124-0032 52.5 µM 0.495381696725173 0.32378374421573 no 1091 0.3101653561096 1578 X1228
SGTC_534 k292-0788 63.4 µM 0.493665226515621 0.324354915195255 no 1092 0.310771313641605 1553 4146317
SGTC_1408 3909-7976 48.8 µM 0.493246008421843 0.324494476686881 no 1093 0.310919386365798 1519 24152374
SGTC_1393 3470-5649 58.2 µM 0.491212986233533 0.325171637505768 no 1094 0.311637907503954 1461 4108395
SGTC_2234 tolnaftate 200 µM 0.489841136334278 0.325628901125816 no 1095 0.312123159535068 1504 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2086 5274770 176.623 µM 0.489668443805942 0.325686481441431 no 1096 0.312184267627863 1495 689278
SGTC_3290 9121031 71.43 µM 0.488628703467291 0.326033246589301 no 1097 0.312552293984011 1462 17014854
SGTC_824 1304-0008 100 µM 0.484961522014728 0.327257492904174 no 1098 0.313851820096 1520 768245
SGTC_619 1652-1634 108 µM 0.484792969176861 0.327313807150877 no 1099 0.313911605274121 1497 5400454
SGTC_697 0508-1955 564 µM 0.483802768445604 0.327644716918853 no 1100 0.314262925068609 1590 6243113
SGTC_2731 amoxapine 43.43 µM 0.483723197414563 0.327671314208306 no 1101 0.314291163906193 1577 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2090 5301565 104.445 µM 0.482989967814506 0.327916443535759 no 1102 0.314551429739077 1517 2056344
SGTC_219 mitoxanthrone 164.414 µM 0.482315491404041 0.328141996301924 no 1103 0.314790922053256 1562 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_329 k048-0121 21.3 µM 0.482218776683316 0.328174343970725 no 1104 0.314825269795686 1515 6832902
SGTC_467 ro 31-8220 72.8 µM 0.481131920144644 0.328537947771425 no 1105 0.315211371476908 1540 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.475970997257406 0.330266727172411 no 1106 0.31704752017554 1520 165521
SGTC_2388 9080168 200 µM 0.475381658339483 0.330464372468667 no 1107 0.317257482666814 1459 15943073
SGTC_3161 9100388 49.47 µM 0.475163766755426 0.330537458268643 no 1108 0.317335125325996 1581 25236368
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.474424591974829 0.330785442462984 no 1109 0.317598579936073 1551 368090
SGTC_501 nsc-95397 161 µM 0.474073345378325 0.330903307487978 no 1110 0.31772380266105 1587 262093
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.472420554395866 0.331458146265922 no 1111 0.318313317966515 1655 5024745
SGTC_2712 st079126 47.7 µM 0.469920941230536 0.332297964454063 no 1112 0.319205751101866 1483 3152970
SGTC_195 4234-0266 16.654 µM 0.468661661266956 0.332721375930121 no 1113 0.319655747523894 1505 2303354
SGTC_956 1185-0240 191 µM 0.468342776580556 0.332828629374633 no 1114 0.319769741300042 1530 1416193
SGTC_3060 1327-0027 12.5 µM 0.467455964558053 0.333126970990557 no 1115 0.32008684522703 1578 16000455 YPR107C YTH1
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.467136748827655 0.333234387526146 no 1116 0.320201021746364 1559 7104
SGTC_769 0302-0231 76 µM 0.466924073661308 0.333305960608287 no 1117 0.320277100476265 1541 571869 YER009W NTF2
SGTC_1179 1021-1431 9.29 µM 0.466216251114371 0.333544212858495 no 1118 0.320530359054362 1548 2840958
SGTC_1008 4106-0037 6 µM 0.465657596883663 0.333732302648218 no 1119 0.320730304304567 1520 2905394
SGTC_1755 st041960 45.185 µM 0.465192397771223 0.333888959511896 no 1120 0.320896841179905 1537 2257073
SGTC_1409 3909-8004 61.9 µM 0.463905376064051 0.334322517806554 no 1121 0.321357770472284 1547 2119279
SGTC_552 k242-0005 476 µM 0.463849644042867 0.334341297220524 no 1122 0.321377736359197 1528 4088318
SGTC_1708 st033234 31.827 µM 0.463050403992983 0.334610654047105 no 1123 0.321664119286535 1598 674664
SGTC_2184 6075246 200 µM 0.462941219274524 0.334647457676706 no 1124 0.321703250483229 1568 2267320
SGTC_1030 k029-0042 36.7 µM 0.462430006602036 0.334819796709094 no 1125 0.321886492570977 1570 6080581
SGTC_2697 mebhydrolin 72.4 µM 0.462301588391946 0.334863094278567 no 1126 0.321932530362095 1675 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_860 0443-0016 25.1 µM 0.460076324466109 0.335613713920956 no 1127 0.322730718621372 1555 5337942
SGTC_2060 5238662 140 µM 0.45950697245569 0.335805871694883 no 1128 0.322935073108225 1525 790130
SGTC_42 0133-0086 60.653 µM 0.459391225144414 0.33584494196453 no 1129 0.322976624216455 1438 162923 Model of phenazepam hydroxylation.
SGTC_336 4111-0029 111 µM 0.457657803488308 0.33643026695709 no 1130 0.323599154062631 1510 3131175
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.457360255820073 0.336530779888037 no 1131 0.323706063131476 1623 688798
SGTC_1244 0416-0015 52.5 µM 0.456883330959741 0.336691911600776 no 1132 0.323877452888766 1533 96201
SGTC_286 k060-0067 22.9 µM 0.455725861723132 0.337083093656404 no 1133 0.324293561240996 1524 5985051
SGTC_2998 9066762 71.4286 µM 0.455638469329816 0.337112636233668 no 1134 0.32432498758727 1639 4945196
SGTC_3352 9151559 45.5865 µM 0.45523043520612 0.337250583494544 no 1135 0.324471733410802 1491 17159339
SGTC_1377 2944-0135 198 µM 0.454985493483754 0.337333403354548 no 1136 0.324559837605927 1594 1894137
SGTC_638 3970-0837 4.09 µM 0.454450767332395 0.337514232702474 no 1137 0.324752209782912 1521 4118451 YLR208W SEC13
SGTC_438 sphingosine 6.67 µM 0.452927715502855 0.338029491557676 no 1138 0.325300396421144 1387 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2163 5671233 125 µM 0.449592210697153 0.339158975046615 no 1139 0.326502252812728 1649 701023
SGTC_596 1155-0152 116 µM 0.448607459821655 0.339492712893287 no 1140 0.326857425741592 1535 280313
SGTC_2400 5203494 178.7 µM 0.448344356544339 0.33958190146232 no 1141 0.326952346534873 1518 6777674
SGTC_3005 9076496 71.4286 µM 0.448295928851727 0.339598318795735 no 1142 0.326969819202377 1590 21368410
SGTC_1835 st008666 49.2 µM 0.447898926558996 0.339732916878371 no 1143 0.327113071567368 1499 690455
SGTC_2626 ethyl orsellinate 100 µM 0.447150923680231 0.339986572328693 no 1144 0.327383046468373 1516 75653 A natural product.
SGTC_670 4204-0025 119 µM 0.44505884990178 0.340696400410096 no 1145 0.32813861283857 1629 719039
SGTC_1526 st051518 75 µM 0.443771193269879 0.341133575408305 no 1146 0.328604008689903 1560 673993
SGTC_872 0588-0139 234 µM 0.44209808841277 0.341701933388758 no 1147 0.329209113813006 1560 2047100
SGTC_2240 6690706 185.951 µM 0.44139754906722 0.34194001510534 no 1148 0.329462608132549 1487 805876
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.441139008016858 0.342027897430742 no 1149 0.329556182556826 1549 2724 A muscle relaxant with antifungal properties.
SGTC_951 1171-0579 82.7 µM 0.441082596895898 0.342047073629653 no 1150 0.329576600996862 1484 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1113 artemisinin 1.17947 µM 0.440487525202833 0.342249385025997 no 1151 0.329792022720185 1669 2240 An anti-malaria and mitochondrial poison.
SGTC_2796 7949634 45.45 µM 0.440342361010501 0.34229874455816 no 1152 0.329844582136433 1543 2971588
SGTC_1802 st050112 57.9 µM 0.439679222616627 0.342524262799058 no 1153 0.330084726536856 1566 4662563
SGTC_119 0121-0043 24.815 µM 0.438684912125025 0.342862510310894 no 1154 0.330444930528014 1585 1092378
SGTC_3302 9125395 16.351 µM 0.438307498651994 0.342990932956075 no 1155 0.330581695419742 1601 17599668
SGTC_2335 9018011 154.17 µM 0.435748072556524 0.343862307948941 no 1156 0.331509761496979 1683 6458208
SGTC_112 phenothiazine 287.218 µM 0.435585951519804 0.343917531220963 no 1157 0.331568582664956 1713 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_754 3474-0146 171 µM 0.435417762483577 0.343974824954116 no 1158 0.331629609830057 1473 24762078
SGTC_2586 curcumin 80 µM 0.43488927434292 0.34415487818245 no 1159 0.331821400119095 1668 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_859 0439-0102 54.6 µM 0.434316750916523 0.34434997388413 no 1160 0.332029220721786 1660 610143
SGTC_2316 5844804 197.44 µM 0.43334721768094 0.344680450913239 no 1161 0.332381269976845 1692 776813
SGTC_575 k072-0246 11.9 µM 0.433237542265334 0.344717842563142 no 1162 0.332421103767344 1603 6796779
SGTC_887 0885-0007 9.62 µM 0.432336168225603 0.345025205537055 no 1163 0.332748551850615 1654 5719458
SGTC_997 3996-0078 137 µM 0.429803449634204 0.345889393816458 no 1164 0.333669311657246 1582 735687
SGTC_2948 9070189 9.45 µM 0.429390975652047 0.346030210156527 no 1165 0.333819360027232 1677 6473636 YDL196W YDL196W
SGTC_2225 6654152 15.4 µM 0.428632916109057 0.346289063019169 no 1166 0.33409519361961 1641 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1738 st035555 74 µM 0.427148123309869 0.34679627983277 no 1167 0.334635721790438 1595 5331140
SGTC_2824 7998404 51.95 µM 0.426330647452411 0.347075653285037 no 1168 0.334933464452314 1605 837851
SGTC_156 3474-0145 5.642 µM 0.426122190016206 0.347146907197662 no 1169 0.335009405842635 1714 2265471
SGTC_170 4197-0004 226 µM 0.425190268423129 0.347465518178956 no 1170 0.335348988881241 1644 218692
SGTC_2453 5731132 22.18 µM 0.424815461366073 0.347593689887435 no 1171 0.33548560283924 1719 1362040
SGTC_1445 4239-0156 97.7 µM 0.424250561743536 0.347786899929996 no 1172 0.335691545003444 1724 4008346
SGTC_3137 9097352 49.47 µM 0.423845749480642 0.347925380343118 no 1173 0.33583915541568 1677 44120435
SGTC_1434 4073-0095 163 µM 0.422221112139378 0.34848134916913 no 1174 0.336431816453552 1608 24133745
SGTC_2439 5492030 7.2 µM 0.421128910356209 0.348855295809401 no 1175 0.336830475862513 1669 5722370
SGTC_1590 st077108 57.8 µM 0.420754340262841 0.34898357447358 no 1176 0.336967238176772 1680 5489485
SGTC_2701 st077767 14.721 µM 0.419429573501008 0.349437404479554 no 1177 0.337451107305313 1586 5721188
SGTC_1736 st036774 51 µM 0.419251548418434 0.349498407583281 no 1178 0.337516151220913 1784 1272247
SGTC_247 mechlorethamine 29.705 µM 0.418252997531224 0.349840648811273 no 1179 0.337881075477076 1621 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1798 st045719 60.953 µM 0.416941813963251 0.350290226412539 no 1180 0.33836048400295 1606 3980186
SGTC_14 0354-0009 295 µM 0.416593165781151 0.350409805974997 no 1181 0.338488004515174 1644 1713507
SGTC_3353 9151644 39.2805 µM 0.415655994559131 0.350731310991689 no 1182 0.338830873224844 1600 4909158
SGTC_700 3453-2283 142 µM 0.415486187729665 0.350789576200792 no 1183 0.338893012192685 1686 565664
SGTC_614 0462-0418 107 µM 0.410150912033299 0.352622031251838 no 1184 0.340847623718458 1532 5188303
SGTC_2455 5377712 9.75 µM 0.409444948126761 0.352864759286707 no 1185 0.341106579777234 1540 2243908
SGTC_1832 st054113 55 µM 0.40864050810611 0.353141418881878 no 1186 0.341401749309367 1656 1251267
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.407662631642998 0.353477830548968 no 1187 0.341760687760262 1716 16725076
SGTC_1145 3546-0597 10.2 µM 0.406174398726566 0.353990036051375 no 1188 0.342307231742263 1608 875334
SGTC_3356 9151811 4.48 µM 0.40545262069985 0.354238545828756 no 1189 0.342572419155485 1592 1859254 YPR165W RHO1
SGTC_3171 9103192 49.47 µM 0.405234366593388 0.354313703432204 no 1190 0.342652622867732 1673 13018434
SGTC_636 0kpi-0074 126 µM 0.404263037074356 0.354648257555884 no 1191 0.343009651667203 1619 616434
SGTC_2625 euphol 100 µM 0.402952454113828 0.355099838140507 no 1192 0.343491601065609 1757 6708538 A triterpene alcohol.
SGTC_2015 5119600 184 µM 0.40089746917971 0.355808323055953 no 1193 0.344247806650909 1736 2828786
SGTC_356 1634-0012 32.5 µM 0.399457501068828 0.356305069386696 no 1194 0.344778066215695 1759 735457
SGTC_1068 loratadine 26.9 µM 0.398878231631307 0.356504969028209 no 1195 0.344991464794993 1600 3957 A H1 histamine antagonist.
SGTC_1205 4161-2785 76 µM 0.398809402006163 0.356528724012009 no 1196 0.345016824399184 1549 3498106
SGTC_756 0508-1999 28.3 µM 0.398771516519325 0.356541799565903 no 1197 0.345030783234409 1546 6753853
SGTC_881 0833-0569 170 µM 0.398574303791916 0.35660986702455 no 1198 0.345103449292667 1556 5418700
SGTC_2317 5986382 200 µM 0.398571623328667 0.356610792210914 no 1199 0.345104436989869 1752 877883
SGTC_3051 9093778 49.47 µM 0.397711646267893 0.356907664674782 no 1200 0.345421375815306 1646 17217378
SGTC_2131 toluylene red 5.2905 µM 0.396865689934661 0.357199781618962 no 1201 0.345733253177763 1572 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1187 1391-0724 117 µM 0.396776291081126 0.357230656805931 no 1202 0.345766217831066 1666 6997986
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.39605299083313 0.357480493368497 no 1203 0.346032968282188 1574 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1705 st027868 56.3335 µM 0.394710229527772 0.357944461106676 no 1204 0.346528376221448 1734 292948
SGTC_2241 6772625 37.8075 µM 0.393706363294373 0.358291466742733 no 1205 0.346898921408095 1581 2285411
SGTC_223 busulfan 5 mM 0.392676240981693 0.358647670003902 no 1206 0.347279310461503 1690 2478 A DNA alkylator.
SGTC_292 k038-0015 474 µM 0.39091316292704 0.35925760534122 no 1207 0.34793071200875 1675 46368540
SGTC_478 N-arachidonylglycine 10 µM 0.389634690037636 0.359700116498435 no 1208 0.348403348289268 1678 5283389
SGTC_980 1473-0395 201 µM 0.389126407096955 0.359876098131172 no 1209 0.34859131993187 1597 768876
SGTC_2838 9002687 71.43 µM 0.388639164674454 0.360044822844134 no 1210 0.348771545339942 1583 6457060
SGTC_2934 9036370 36.88 µM 0.388295978045871 0.360163679575382 no 1211 0.348898506643226 1764 6462800
SGTC_3104 9120930 49.47 µM 0.387911165457425 0.360296968812239 no 1212 0.349040887520744 1657 17014836
SGTC_1322 1348-1070 12 µM 0.387267026141036 0.360520120191129 no 1213 0.349279266994393 1650 6758089
SGTC_1512 0259-0544 12.2 µM 0.386435770930619 0.360808164978921 no 1214 0.349586981154406 1701 18476
SGTC_2327 6189656 200 µM 0.386424843133016 0.360811952182392 no 1215 0.349591027066684 1767 5349088
SGTC_2723 salbutamol 83.58 µM 0.385906970319167 0.360991444953467 no 1216 0.34978278409297 1718 9884233 β2-adrenoceptor agonist
SGTC_2943 9068529 45.32 µM 0.385186948650097 0.361241052627107 no 1217 0.350049456116466 1650 3270634
SGTC_446 go6976 132 µM 0.384903653388364 0.361339277917997 no 1218 0.350154399521321 1748 3501 A protein kinase C inhibitor.
SGTC_3031 9088762 49.47 µM 0.384696736521462 0.361411026756721 no 1219 0.350231056678341 1588 205253
SGTC_608 k048-0125 159 µM 0.38240460309348 0.36220615417274 no 1220 0.351080638295097 1742 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2350 9023895 38.85 µM 0.382312269722763 0.362238196556443 no 1221 0.351114877389484 1729 2997209
SGTC_2972 9093619 59.92 µM 0.381574723400477 0.362494181364693 no 1222 0.351388417953748 1590 25236256
SGTC_775 4577-0580 57.3 µM 0.381194441009834 0.36262619238072 no 1223 0.351529486860572 1703 2006902
SGTC_852 0418-0143 439 µM 0.381090237338958 0.362662368436059 no 1224 0.351568145647019 1743 5369229
SGTC_2696 st077691 74.316 µM 0.380013905780676 0.363036106702883 no 1225 0.35196754640503 1666 757133
SGTC_2935 9038016 29.96 µM 0.378685288682692 0.363497626838545 no 1226 0.352460789551265 1720 6463195
SGTC_1324 1418-0026 34.4 µM 0.3780388965172 0.363722235022394 no 1227 0.352700849553699 1694 1372513
SGTC_2995 9067767 71.4286 µM 0.377439439815651 0.363930575949324 no 1228 0.352923530889481 1674 11673567
SGTC_2677 mitomycin C 100 µM 0.376616901066517 0.36421651441168 no 1229 0.353229162935646 1670 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_674 0498-0004 451 µM 0.374862477650941 0.364826655575607 no 1230 0.353881373031782 1631 4231473
SGTC_2863 9028737 58.44 µM 0.373377750372111 0.365343271337706 no 1231 0.354433658376581 1775 6460917
SGTC_3321 9137793 26.8275 µM 0.373285171945946 0.365375492412189 no 1232 0.35446810563498 1662 4904192
SGTC_1819 st053448 58.6 µM 0.372056040220373 0.365803370440118 no 1233 0.354925562688029 1690 2857616
SGTC_2353 9059630 146.67 µM 0.370810086191742 0.366237274993349 no 1234 0.355389494207656 1738 4779114
SGTC_185 k048-0037 25.491 µM 0.369390469513186 0.366731866213547 no 1235 0.355918350351973 1798 6827589
SGTC_2417 cerulenin 830 nM 0.367868664785897 0.367262305333053 no 1236 0.356485583114064 1675 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1956 st077085 54 µM 0.365752162971446 0.368000452784492 no 1237 0.357275009258963 1647 24208685
SGTC_2850 9015429 58.44 µM 0.361988906169176 0.369314122567013 no 1238 0.358680160336051 1634 6457570
SGTC_3294 9122953 26.2835 µM 0.360941284846667 0.369680096477369 no 1239 0.359071670072806 1629 16459826
SGTC_1964 st076914 61 µM 0.36081878965662 0.369722896416107 no 1240 0.359117457797248 1687 24208661
SGTC_1330 1469-0054 61.8 µM 0.360063553719838 0.369986812222389 no 1241 0.35939980364401 1830 7102664
SGTC_3170 9103054 49.47 µM 0.35969675473035 0.37011501155424 no 1242 0.35953695959196 1653 16432970
SGTC_2647 atorvastatin 60.16 µM 0.358756628457833 0.370443659461186 no 1243 0.359888580533753 1753 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_15 0266-0086 27.098 µM 0.358600640252184 0.370498198734893 no 1244 0.359946933878785 1777 1712902 YIL048W NEO1
SGTC_715 0868-0130 184 µM 0.356222744757615 0.371329921055739 no 1245 0.360836879918925 1845 2876258
SGTC_2728 chlorpromazine 9.18 µM 0.355134573679123 0.371710734072115 no 1246 0.361244388269917 1723 2726 A thorazine and dopamine antagonist.
SGTC_1224 0823-0416 294 µM 0.354647934659857 0.371881077428995 no 1247 0.361426680338224 1771 3598164
SGTC_1864 st057645 30.4 µM 0.353870328735083 0.372153323032664 no 1248 0.361718032161324 1757 688666
SGTC_2423 st077119 87.2 µM 0.352925761294795 0.372484109069801 no 1249 0.362072048629636 1667 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1949 st076024 69.1 µM 0.352919754064106 0.372486213093911 no 1250 0.362074300470602 1612 2921930
SGTC_1166 k206-0078 225 µM 0.352192460164434 0.372740974864407 no 1251 0.36234696554346 1656 5404595
SGTC_2932 9016711 44.54 µM 0.351202132612588 0.37308796347056 no 1252 0.362718355158065 1848 7117328
SGTC_894 0960-0238 55.9 µM 0.351072133320355 0.373133519963982 no 1253 0.362767116695228 1747 6741907 YDL195W SEC31
SGTC_846 0335-0850 148 µM 0.350766227101959 0.373240727657054 no 1254 0.362881868078899 1715 6819598
SGTC_342 k048-0088 23.3 µM 0.35074938920888 0.373246628939081 no 1255 0.362888184658338 1649 6820570
SGTC_1713 st033146 12.748 µM 0.350355840024927 0.373384567056809 no 1256 0.363035831607356 1816 674619
SGTC_562 3772-2733 112 µM 0.348571920101493 0.374010030278255 no 1257 0.363705355783229 1794 2876874 YIL048W NEO1
SGTC_365 0121-0052 13.6 µM 0.347561414376038 0.374364472761684 no 1258 0.364084794245818 1746 3101739
SGTC_1684 st024538 14.6195 µM 0.347257332535229 0.374471152556521 no 1259 0.364199001144639 1680 6732859
SGTC_2883 9059145 45.46 µM 0.34703580543054 0.3745488760604 no 1260 0.364282209772743 1671 16476510
SGTC_3078 9116413 49.47 µM 0.346658816474407 0.374681155576556 no 1261 0.364423826715447 1664 17177322
SGTC_389 tpck 16.7 µM 0.345015308439945 0.375258008893413 no 1262 0.365041431047208 1718 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2855 9016525 58.44 µM 0.344595085665058 0.375405547335755 no 1263 0.365199400414354 1682 43811474
SGTC_1001 4048-4355 44.4 µM 0.344234870705648 0.375532031796034 no 1264 0.365334829965335 1674 21824233
SGTC_7 0192-1582 4.227 µM 0.344141574506415 0.375564793637464 no 1265 0.365369909155089 1740 252616
SGTC_296 1222-0039 74.9 µM 0.342329193679266 0.376201406039785 no 1266 0.366051583958061 1663 5984176
SGTC_1470 k295-0292 231 µM 0.341598719856777 0.376458085845444 no 1267 0.366326450360081 1801 5045612
SGTC_1672 st016598 6.51 µM 0.339505156985752 0.377194041265179 no 1268 0.36711460641581 1670 4665860 YNL267W PIK1
SGTC_2984 9022109 38.96 µM 0.338342436437442 0.37760296827925 no 1269 0.367552573862676 1753 6459207
SGTC_1518 st038567 90.8 µM 0.337344918147019 0.377953903309337 no 1270 0.367928451154947 1716 77966
SGTC_465 cgp-37157 41 µM 0.337092513392693 0.378042717331722 no 1271 0.368023580472207 1808 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_657 3534-0529 86.7 µM 0.335385269325443 0.378643616773167 no 1272 0.368667239261788 1803 1049549
SGTC_694 1315-0438 43.2 µM 0.332426084627039 0.379685856868292 no 1273 0.369783772355808 1776 6793154
SGTC_1335 1486-0900 202 µM 0.332310614427662 0.37972654384758 no 1274 0.369827362871166 1715 X1335
SGTC_2735 sertaconazole 140 nM 0.330323234798031 0.380427023541002 no 1275 0.370577869248894 1819 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2385 9074692 200 µM 0.329132991556188 0.380846729358072 no 1276 0.371027584258433 1694 17046906
SGTC_2253 7938677 135.83 µM 0.329043395313047 0.380878328636213 no 1277 0.371061443952345 1856 2301972
SGTC_1746 st038117 42 µM 0.327876335081036 0.381290006133668 no 1278 0.371502583702177 1736 2898218
SGTC_2651 TUB2.036 5 µM 0.327779494030605 0.381324172608887 no 1279 0.371539196464419 1818 15992207 YFL037W TUB2
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.327252366626298 0.381510164555999 no 1280 0.371738508255387 1696 688664
SGTC_998 3996-0085 177 µM 0.326330116350519 0.381835637689073 no 1281 0.372087302367991 1846 715391
SGTC_2686 alizarin 95.37 µM 0.325698326109485 0.382058652243637 no 1282 0.372326305404681 1675 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1331 1472-0049 76.2 µM 0.325474698735001 0.382137599469756 no 1283 0.372410914294045 1696 24051409
SGTC_330 1488-0319 80.1 µM 0.325366898713481 0.382175657888196 no 1284 0.372451702377899 1760 6846614
SGTC_2571 chrysanthemic acid 100 µM 0.324439937750479 0.38250296514295 no 1285 0.372802493787703 1661 2743 An insecticide.
SGTC_2617 dihydrotanshinone i 20.83 µM 0.324143994520242 0.38260747953945 no 1286 0.372914510319986 1694 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_936 3005-4620 401 µM 0.323340114895257 0.382891418320307 no 1287 0.373218838458264 1868 777207
SGTC_327 1273-0057 3.96 µM 0.323291371981058 0.382908636858348 no 1288 0.373237293816892 1777 3108138
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.321973340976659 0.383374321731266 no 1289 0.373736445399224 1771 97141
SGTC_2064 5220758 200 µM 0.320909347525701 0.383750373398673 no 1290 0.374139544996224 1757 788518
SGTC_1637 st007924 17.4 µM 0.320452065422154 0.383912026196722 no 1291 0.374312831080683 1722 683336
SGTC_3296 9122258 64.045 µM 0.31962924147715 0.38420295175449 no 1292 0.374624702408141 1758 4730474
SGTC_2553 4-methylesculetin 85.09 µM 0.31788464093849 0.38482000518311 no 1293 0.375286221768069 1700 5319502
SGTC_2766 oltipraz 83.91 µM 0.315225354505206 0.38576113788146 no 1294 0.376295278027082 1836 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_493 zm226600 134 µM 0.315198649774892 0.385770592219888 no 1295 0.376305415339126 1792 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1991 st073000 8.92 µM 0.314754476348802 0.385927853928372 no 1296 0.376474039346382 1832 4301969 YIL048W NEO1
SGTC_968 1309-0633 340 µM 0.314615223178761 0.385977161035225 no 1297 0.376526909651027 1874 3761976
SGTC_1748 st037455 53.6035 µM 0.314551269191783 0.385999806638398 no 1298 0.376551191862122 1784 580690
SGTC_555 4296-0685 37 µM 0.313814921802801 0.386260569415826 no 1299 0.376830805263839 1786 2908540 YHR072W ERG7
SGTC_2298 7976326 193.81 µM 0.31312021183193 0.38650663423991 no 1300 0.377094666921374 1820 2235818
SGTC_1778 st046819 58.9 µM 0.312528783578554 0.386716152868212 no 1301 0.377319345816578 1743 671715
SGTC_2369 9071472 200 µM 0.312497334641771 0.38672729485416 no 1302 0.377331294181432 1799 17296037
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.312153781212666 0.386849017845621 no 1303 0.377461827757051 1719 4174840
SGTC_12 0849-0099 9.267 µM 0.312004814032537 0.386901801250009 no 1304 0.377518432384338 1855 6071388
SGTC_444 curcumin 90.4 µM 0.31174658759712 0.386993303341517 no 1305 0.377616559633238 1796 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1609 st001574 46.4 µM 0.310918558894907 0.387286756219423 no 1306 0.377931267648635 1727 3960012
SGTC_3118 9124250 49.47 µM 0.310839345843872 0.387314832656242 no 1307 0.377961378321106 1747 1504786
SGTC_1719 st032227 49.2 µM 0.309229466622388 0.387885569089263 no 1308 0.378573490240192 1688 3125804
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.307310996981044 0.388566023714623 no 1309 0.379303333023419 1772 521171
SGTC_1277 0873-0036 22 µM 0.307287695836524 0.388574290414923 no 1310 0.379312200120802 1848 5965735
SGTC_1161 k007-0610 110 µM 0.306990135457921 0.388679862303519 no 1311 0.379425440347751 1826 5843850
SGTC_2458 5808907 16.39 µM 0.306511643669573 0.388849644354519 no 1312 0.379607557915204 1894 2731747
SGTC_1679 SEC14.276 6.7 µM 0.305046061835426 0.389369805084612 no 1313 0.380165535410909 1924 1005053 YMR079W SEC14
SGTC_3054 9094397 49.47 µM 0.303832706475478 0.389800596292423 no 1314 0.380627673882127 1721 2598354
SGTC_1218 1348-1416 30.7 µM 0.302840188099958 0.390153081973005 no 1315 0.381005827479813 1745 6787668
SGTC_299 1273-0059 1.44 µM 0.299944647891518 0.391181927204024 no 1316 0.38210968860605 1847 2848077
SGTC_2815 7968870 71.43 µM 0.299491603675286 0.391342972285023 no 1317 0.382282488753531 1728 2977326 YHR190W ERG9
SGTC_1311 1190-0148 100 µM 0.298740669395691 0.391609950318907 no 1318 0.382568961770824 1880 1961333
SGTC_3042 9091578 49.47 µM 0.298559623460882 0.391674324830801 no 1319 0.382638038388739 1830 25236497
SGTC_850 0388-0143 75.9 µM 0.295764668612541 0.392668502416936 no 1320 0.383704903399634 1778 67273
SGTC_2568 diosmetin 100 µM 0.29431937765177 0.393182873972964 no 1321 0.384256933418522 1931 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_724 3910-0327 137 µM 0.294296627910116 0.393190971981495 no 1322 0.384265624580597 1741 2885483
SGTC_1061 3448-9325 110 µM 0.294041932448415 0.39328163664974 no 1323 0.384362930735605 1892 723482
SGTC_191 3914-0123 66.505 µM 0.290222359217929 0.394641992638288 no 1324 0.385823065903357 1763 3144412
SGTC_394 menadione 8.33 µM 0.290108590452827 0.394682531630164 no 1325 0.385866582024789 1909 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3011 9081274 71.4286 µM 0.289830963352908 0.394781462714373 no 1326 0.385972779366141 1772 6625322
SGTC_2511 berberine 10.47 µM 0.289201171024064 0.395005911332233 no 1327 0.386213717887623 1770 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_582 0987-0078 156 µM 0.286982962054985 0.395796725043548 no 1328 0.387062683038286 1867 1625765
SGTC_2279 7948423 32.93 µM 0.285994144910591 0.39614938674236 no 1329 0.387441303017582 1960 1247112
SGTC_625 k213-0058 121 µM 0.2837169185025 0.396961882552104 no 1330 0.3883136641013 1861 3655420
SGTC_2736 butenafine 14.65 µM 0.283381985849545 0.397081421620925 no 1331 0.388442017937087 1881 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2483 5729050 27.16 µM 0.280365093935534 0.398158599337304 no 1332 0.389598707274688 1940 2865180
SGTC_3221 9128209 49.47 µM 0.279347889901094 0.39852196632604 no 1333 0.389988928802849 1804 16460723
SGTC_2481 5478948 45.16 µM 0.279079155869345 0.398617978564526 no 1334 0.390092039540061 1795 77792
SGTC_602 3130-1533 38.1 µM 0.278622262551817 0.398781229695318 no 1335 0.390267362984606 1918 720941
SGTC_1127 asiatic acid 681.4 nM 0.275354452017108 0.399949355604533 no 1336 0.391521966978853 1741 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.275257654379875 0.399983971025665 no 1337 0.391559147587046 1776 803109
SGTC_2424 5537928 59.2 µM 0.275038225381145 0.400062443073784 no 1338 0.391643435374336 1766 5382802
SGTC_3009 9080819 71.4286 µM 0.274681547415072 0.400190006613348 no 1339 0.391780454538737 1796 17027216
SGTC_347 4534-1311 26.2 µM 0.274535819505397 0.400242128311401 no 1340 0.391836440319979 1791 2862016
SGTC_2777 climbazole 1.536 µM 0.272142738505557 0.40109830191553 no 1341 0.392756134315615 1862 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2382 9035899 200 µM 0.271232200607726 0.401424190466733 no 1342 0.393106224193559 1800 6462679
SGTC_549 1661-1316 519 µM 0.268567745140481 0.402378212843157 no 1343 0.394131168118902 1941 2857282
SGTC_487 nimodipine 119 µM 0.26829768942851 0.40247494028388 no 1344 0.394235092307805 1939 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1176 0848-0131 83.3 µM 0.26647131585739 0.403129259693067 no 1345 0.394938123827125 1979 6769040
SGTC_2606 farnesol 9.78 µM 0.265037941335409 0.403642972794396 no 1346 0.395490116832509 1930 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2839 9003951 25.97 µM 0.264405992531405 0.403869512442023 no 1347 0.39573354720961 1985 2990634
SGTC_2183 6420625 130.508 µM 0.263739818197851 0.404108356098804 no 1348 0.395990205501924 1847 2897619
SGTC_1359 1582-0056 520 nM 0.262492282166476 0.404555731614364 no 1349 0.396470967378572 1891 3661189
SGTC_603 3794-0023 45.9 µM 0.262226158496812 0.404651181674356 no 1350 0.396573543626892 1954 3802260
SGTC_3242 9133940 49.47 µM 0.261127821028075 0.405045180218944 no 1351 0.39699696884586 1910 17248444
SGTC_2652 actinonin 100 µM 0.259280339092287 0.405708130827358 no 1352 0.397709473986956 1892 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_426 0988-0037 14.6 µM 0.257858979121748 0.406218356030195 no 1353 0.398257872190539 2029 5383008
SGTC_1406 3909-7906 11.9 µM 0.256953219143417 0.406543579603284 no 1354 0.398607443240497 1897 X1406
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.25620357326707 0.406812797381576 no 1355 0.398896824813301 1779 23665772 A membrane-active detergent.
SGTC_2957 9076800 11.52 µM 0.255969323338034 0.406896931800865 no 1356 0.398987262398669 1799 16459615
SGTC_1310 1188-0297 994 nM 0.255419543325223 0.407094410511661 no 1357 0.399199538937886 1899 1588352
SGTC_2203 7227154 166.4 µM 0.254461981790634 0.407438419030875 no 1358 0.399569335868852 1881 896304
SGTC_18 0111-0177 500 nM 0.253537978276908 0.407770439365209 no 1359 0.399926258597846 1859 721752
SGTC_2807 7945238 51.95 µM 0.250534707262957 0.408850055173265 no 1360 0.401086933895028 1862 17148797
SGTC_875 0709-0210 25.7 µM 0.249011142026997 0.409398011453918 no 1361 0.4016760813713 2021 6251364
SGTC_2119 5528445 120.635 µM 0.248596155566291 0.409547293706598 no 1362 0.401836591288028 1968 791935
SGTC_404 fumagillin 50 µM 0.248418409635674 0.40961123790917 no 1363 0.401905345548517 1881 12015870 A methionine aminopeptidase binder.
SGTC_142 0335-0849 62.6745 µM 0.248118487107554 0.409719140665016 no 1364 0.402021366066399 1887 3889043 YPR107C YTH1
SGTC_2412 st077135 33.4 µM 0.24720384675221 0.410048241882059 no 1365 0.402375234200435 1932 13258915
SGTC_2142 5622915 118.518 µM 0.246070053007817 0.410456285693308 no 1366 0.402814002335963 1865 5322196
SGTC_167 3672-0051 66.205 µM 0.245072050356767 0.41081553955873 no 1367 0.403200321852364 1839 3237971
SGTC_1405 3909-7894 12 µM 0.241019571656962 0.412275087663187 no 1368 0.404769973804692 1979 7104060
SGTC_2806 7952793 58.44 µM 0.240647838335625 0.412409032910683 no 1369 0.40491403493762 1895 2972490
SGTC_2908 7930301 100 µM 0.2405216467542 0.412454505361411 no 1370 0.404962942018863 1878 2223178
SGTC_3209 9113616 49.47 µM 0.239862703459878 0.412691971072761 no 1371 0.405218347599002 2050 16649353
SGTC_3141 9094609 49.47 µM 0.238670402534102 0.413121725917838 no 1372 0.405680584457083 1784 25236309 YDL196W YDL196W
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.238329078267974 0.413244772573732 no 1373 0.405812934910113 1890 2346 DNA damaging agent; causes G2/M arrest.
SGTC_3343 9148379 18.9835 µM 0.237878365463418 0.413407266614522 no 1374 0.405987717893125 1995 1955036
SGTC_889 0919-1524 82.7 µM 0.236047896962479 0.414067351711612 no 1375 0.406697751850912 1862 3905452
SGTC_197 4544-0043 41.561 µM 0.235451438363823 0.414282493144398 no 1376 0.406929182980274 1943 896523
SGTC_1815 st051655 58.2 µM 0.234856744528755 0.414497023639086 no 1377 0.407159961725745 2017 5984156
SGTC_901 1112-0062 60.1 µM 0.234072620401525 0.414779928402201 no 1378 0.407464300640714 1887 1908457
SGTC_106 0092-0003 11.579 µM 0.231721079019419 0.415628607375584 no 1379 0.408377329123465 2006 1072148
SGTC_2076 5212012 200 µM 0.230669257032472 0.416008341041596 no 1380 0.408785879401084 1937 604802
SGTC_2016 5121758 140 µM 0.230043680762984 0.41623422671301 no 1381 0.409028913718203 1952 2795203
SGTC_539 4859-0462 2.54 µM 0.226602111364097 0.41747741576493 no 1382 0.410366575183913 2034 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_187 1488-2104 32.728 µM 0.226279043733904 0.417594159200334 no 1383 0.410492198198926 1993 2852859
SGTC_87 0100-0052 35.5 µM 0.222280145703099 0.419039795738498 no 1384 0.412047903475035 1934 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_3216 9129716 49.47 µM 0.222216951777686 0.419062649724066 no 1385 0.412072499194875 1884 8056934
SGTC_1234 0326-0494 15.5 µM 0.220866749579497 0.419551013398245 no 1386 0.412598094027331 1998 1547813
SGTC_1752 st044819 83.042 µM 0.220843298442807 0.419559496694086 no 1387 0.41260722426716 1870 441209 YML126C ERG13
SGTC_2081 5214970 32.255 µM 0.220726289948149 0.419601824312904 no 1388 0.41265277993466 2003 2063512
SGTC_1644 st010134 20.9 µM 0.220194534336871 0.419794197690602 no 1389 0.412859826571249 2036 3818134
SGTC_649 1123-0311 367 µM 0.220173960840322 0.419801640955694 no 1390 0.412867837643271 2011 693629 YIL048W NEO1
SGTC_1868 st057644 42.7 µM 0.218327464696236 0.420469799507982 no 1391 0.413586988420706 1946 688665
SGTC_1002 4049-0206 172 µM 0.218278168467846 0.420487640602881 no 1392 0.413606191698477 1876 4662749
SGTC_3328 9140624 29.0385 µM 0.217768326260023 0.420672170241203 no 1393 0.413804812139062 2017 4904392
SGTC_577 r071-0003 38.6 µM 0.215921304470087 0.421340817391971 no 1394 0.414524545111757 1931 4568517 YMR134W ERG29
SGTC_268 camptothecin 39.6153 µM 0.215906114182376 0.421346317427243 no 1395 0.41453046553748 1956 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1651 st011928 86.1 µM 0.215815727206241 0.421379044679451 no 1396 0.414565694328876 1961 720198
SGTC_1965 Pectolinarigenin 58.4 µM 0.215676164339514 0.421429578569986 no 1397 0.414620091027597 1906 5320438 An anti-inflammatory.
SGTC_516 3992-2719 87.3 µM 0.213460311163707 0.422232082904815 no 1398 0.415483971395872 1805 5350887 YDR037W KRS1
SGTC_1080 nisoldipine 24.4 µM 0.213389317055271 0.422257799839146 no 1399 0.415511656189191 1916 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1879 gemcitabine 100 µM 0.213269030668497 0.422301373184629 no 1400 0.415558563908556 1957 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1701 st028638 40.4 µM 0.212973014453541 0.422408608127361 no 1401 0.415674005582079 1997 3490878
SGTC_1423 4048-0112 5.59 µM 0.212970559688023 0.422409497415675 no 1402 0.415674962932508 2022 X1423
SGTC_584 0986-0246 15.4 µM 0.212720134012713 0.422500221244343 no 1403 0.415772630746205 2044 53315 YDR232W HEM1
SGTC_1135 dihydrocapsaicin 536.708 nM 0.211558463896216 0.422921123006506 no 1404 0.416225758397291 1807 107982 A Capsaicinoid.
SGTC_729 4092-0585 94.1 µM 0.211376422362476 0.422987089136318 no 1405 0.416296776662053 1867 2169061
SGTC_536 3852-0578 10.6 µM 0.211076284215212 0.423095854480907 no 1406 0.41641387288751 2046 2869208
SGTC_1373 2887-0003 58.5 µM 0.210304176987603 0.423375680913814 no 1407 0.416715137711745 1910 776948
SGTC_2178 5812956 200 µM 0.210016108896936 0.42348009221018 no 1408 0.416827550162005 2023 5403383
SGTC_1615 st002656 86.5 µM 0.209988962290051 0.423489931870832 no 1409 0.416838143899204 1975 1584458
SGTC_305 1682-2595 20.8 µM 0.20976618900123 0.423570680912012 no 1410 0.416925081599946 1961 226033
SGTC_284 0988-0104 32.6 µM 0.208603301831638 0.423992246784484 no 1411 0.417378966397146 2021 4666532
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.208248883871154 0.42412074648804 no 1412 0.417517320676859 1895 6708561
SGTC_2680 butyl paraben 22.24 µM 0.208173345545264 0.424148135117749 no 1413 0.417546809923834 2021 7184 An antifungal and steroid mimetic.
SGTC_660 4031-1742 102 µM 0.208067397113858 0.424186550437986 no 1414 0.417588171688754 1913 6738706
SGTC_628 1636-0253 16 µM 0.207358962174897 0.424443436869082 no 1415 0.417864764738076 2038 4456143
SGTC_3206 9114350 49.47 µM 0.207352688811244 0.424445711804435 no 1416 0.41786721421849 2047 17087243
SGTC_1011 4112-3381 17.4 µM 0.206125295235725 0.424890854852677 no 1417 0.41834652013829 1966 2877139
SGTC_2665 lovastatin 100 µM 0.206101707095616 0.424899410584522 no 1418 0.418355732664726 1943 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_962 1254-0300 21.5 µM 0.20426893751862 0.425564288315979 no 1419 0.419071671226921 1939 7340576
SGTC_2405 ticlatone 3.52 µM 0.203122843064758 0.425980167161669 no 1420 0.419519508851163 1804 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2180 6301957 200 µM 0.202803678100371 0.426095995991052 no 1421 0.419644241485223 2044 845462
SGTC_576 1073-0113 22.7 µM 0.199482091655594 0.427301816571655 no 1422 0.420942825315335 2067 5439563
SGTC_224 benfluorex 43.875 µM 0.199315315937524 0.427362378419058 no 1423 0.421008049572904 2046 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2300 7976697 71.57 µM 0.196659072554191 0.428327179143282 no 1424 0.422047169969206 1909 2236109
SGTC_2858 9025781 8.96 µM 0.196586898843417 0.428353400085046 no 1425 0.422075411878792 2052 4894980 YPL153C RAD53
SGTC_3043 9092303 49.47 µM 0.193167344407165 0.42959609574898 no 1426 0.423413956222184 1903 25236084
SGTC_637 1181-0519 7.26 µM 0.191707628508809 0.430126782410843 no 1427 0.423985615070146 2007 6252091 YGR060W ERG25
SGTC_1494 4358-1428 177 µM 0.191696080659729 0.430130981190915 no 1428 0.423990138117044 2113 1564571
SGTC_2322 7413319 38.22 µM 0.19106468527559 0.430360567589787 no 1429 0.424237457485436 1970 1840400
SGTC_496 calpeptin 138 µM 0.191030108133094 0.430373141123896 no 1430 0.424251002313139 1941 73364 A calpain inhibitor.
SGTC_2603 homopterocarpin 100 µM 0.190555772157103 0.430545634435545 no 1431 0.424436821923337 1937 101795 A weak amylase inhibitor.
SGTC_521 r062-0005 13.8 µM 0.19041301957554 0.430597549318942 no 1432 0.424492748083175 1926 2832033
SGTC_671 0560-0003 407 µM 0.19040841888465 0.430599222473832 no 1433 0.424494550520523 2015 3238678
SGTC_2055 5235184 200 µM 0.190252795601364 0.430655819458698 no 1434 0.424555520818786 1969 2836034
SGTC_3227 9130768 49.47 µM 0.190065246349924 0.430724029153575 no 1435 0.424629001514179 2016 17720899
SGTC_2211 7117706 200 µM 0.187748835192261 0.43156665336287 no 1436 0.425536772990011 2062 822771
SGTC_1800 st050079 29.0735 µM 0.186746990355977 0.431931183965781 no 1437 0.42592950558157 1996 3645560
SGTC_1944 st076371 56.9 µM 0.185562791231511 0.43236214060863 no 1438 0.426393817502362 1904 24208455
SGTC_1366 1683-0113 21.9 µM 0.184781474593285 0.432646523372373 no 1439 0.42670021938345 1958 708623
SGTC_2801 7907800 81.82 µM 0.183383141325575 0.433155574174474 no 1440 0.42724870141687 1970 6620925
SGTC_2644 guaiazulene 100 µM 0.182372387365672 0.433523599294126 no 1441 0.427645247045754 2077 3515 A coloring agent.
SGTC_1191 1487-1166 10.6 µM 0.181920021855006 0.433688328566676 no 1442 0.427822745756163 2050 3955771
SGTC_3349 9149703 23.001 µM 0.181542198926747 0.433825921925866 no 1443 0.427971006722181 2067 4910494
SGTC_1581 himbacine 57.9 µM 0.181437252697794 0.433864142057641 no 1444 0.428012190330458 1942 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_3119 9125183 49.47 µM 0.180520156753279 0.434198163446628 no 1445 0.428372115764594 2088 22695334
SGTC_777 1315-0167 517 µM 0.180297640132063 0.434279214742881 no 1446 0.428459454107974 1932 4221767
SGTC_1387 3342-1166 1.8 µM 0.180127480287963 0.434341197037516 no 1447 0.428526244646848 1987 3418228
SGTC_1763 st044482 94.5 µM 0.179365992484477 0.434618595755303 no 1448 0.428825166193914 2039 88505
SGTC_1503 4585-0012 61.3 µM 0.179091257473736 0.434718685555996 no 1449 0.42893302327738 2054 2922052
SGTC_2925 9010536 32.5 µM 0.178925626002731 0.434779029435644 no 1450 0.428998050417352 2012 2994177
SGTC_1687 st020778 55.3625 µM 0.178897035956554 0.434789445691499 no 1451 0.429009275103308 2002 4259299
SGTC_2508 celastrol 40.54 µM 0.177724621650314 0.435216632116482 no 1452 0.42946962389584 2098 122724 Celastrol is a natural product and antioxidant.
SGTC_1301 naphtanilide LB 4.81 µM 0.175609622749952 0.43598745405399 no 1453 0.430300320990811 2091 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_38 0929-0051 58.268 µM 0.174638242734335 0.436341560044374 no 1454 0.430681948486134 2106 1379719
SGTC_1497 4476-2978 41.3 µM 0.174336064557617 0.436451726221753 no 1455 0.430800678890359 2050 1528379
SGTC_2826 7992541 19.48 µM 0.174040684493841 0.436559418751303 no 1456 0.430916744258085 2101 2985066
SGTC_200 k038-0079 37.545 µM 0.173864018918533 0.436623831448635 no 1457 0.430986165319186 2046 3436683
SGTC_2310 7668677 200 µM 0.173482579347004 0.436762910970588 no 1458 0.431136059966282 2040 2197143
SGTC_772 k072-0172 35.3 µM 0.17323619115138 0.436852752561406 no 1459 0.431232888628646 1876 5861980
SGTC_993 3909-8757 62.7 µM 0.172258714438689 0.437209206159403 no 1460 0.431617070112518 1998 4288324 YLR208W SEC13
SGTC_1027 k015-0025 8.67 µM 0.172051402463477 0.437284812578105 no 1461 0.431698559073932 1990 3598955
SGTC_1287 0971-0001 34.6 µM 0.171625331765892 0.437440207217497 no 1462 0.431866045538009 2010 4665869
SGTC_1786 berberine 21.6 µM 0.171287527669572 0.437563416508413 no 1463 0.431998843506485 2063 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1664 st014217 9.02 µM 0.171241491633356 0.437580207973889 no 1464 0.432016941845851 2144 3982782
SGTC_3274 9138298 49.47 µM 0.169738503710207 0.438128478557847 no 1465 0.432607895922743 2118 17015756
SGTC_947 3447-0010 211 µM 0.168743686343051 0.438491440483057 no 1466 0.432999127370295 2097 748350
SGTC_94 0334-0113 514.748 µM 0.168480614882459 0.438587431510883 no 1467 0.433102596379911 1941 6795178
SGTC_2156 5649887 115 µM 0.168410926446239 0.438612860433853 no 1468 0.433130006406322 2097 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3201 9113999 49.47 µM 0.168102474473004 0.43872541588583 no 1469 0.433251331353173 2052 16649224
SGTC_1265 0819-1001 68.8 µM 0.167664857516793 0.438885112696416 no 1470 0.433423472195924 2081 3106768
SGTC_833 3852-0053 558 µM 0.165334398405675 0.439735719467897 no 1471 0.434340392678976 2047 3123681
SGTC_1937 st074714 47.2 µM 0.164716219617349 0.439961398718766 no 1472 0.434583674977677 1924 17250970
SGTC_1731 st035964 63 µM 0.163649684192368 0.440350805873384 no 1473 0.435003464795935 1930 6739575
SGTC_3123 9126162 49.47 µM 0.163471191287393 0.440415981801604 no 1474 0.435073727020588 2001 25239884
SGTC_3196 9111891 49.47 µM 0.162401897682931 0.440806463575285 no 1475 0.435494688271286 2122 18891510
SGTC_2352 9027995 87.8 µM 0.161722869336966 0.441054459234069 no 1476 0.435762047241548 2032 2997347
SGTC_98 0074-0023 107.663 µM 0.161479433332357 0.441143372898018 no 1477 0.435857904298484 1968 3563821
SGTC_573 3702-0553 84.7 µM 0.160920423930816 0.441347559233254 no 1478 0.436078037987058 2042 1222756
SGTC_1241 0364-0022 50.8 µM 0.15849869093817 0.442232311903495 no 1479 0.437031926052576 2057 4563895
SGTC_3198 9112019 49.47 µM 0.154326280194811 0.443757328485619 no 1480 0.438676238465916 2062 45595555
SGTC_2227 7312221 64.1025 µM 0.154067804511618 0.443851829016706 no 1481 0.438778136711269 2124 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3211 9128781 49.47 µM 0.153606431172892 0.444020518292769 no 1482 0.438960032892108 1881 17194361
SGTC_537 1334-0398 209 µM 0.152635192466046 0.444375659818609 no 1483 0.439342985296552 2161 5846986
SGTC_1850 st056238 17 µM 0.152510265911741 0.444421343502067 no 1484 0.439392247062736 2142 5393177
SGTC_826 1683-5028 118 µM 0.151865314122611 0.444657203998256 no 1485 0.439646583121011 2038 722377
SGTC_3059 1327-0034 3 µM 0.150781266553523 0.445053687038835 no 1486 0.440074132211703 2017 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1821 st053465 65.6 µM 0.150515142277817 0.445151028605728 no 1487 0.440179102508737 2030 675086
SGTC_1162 k048-0130 20.1 µM 0.14816449687548 0.446010978538251 no 1488 0.441106474953876 2011 6797406
SGTC_464 bw-b 70c 158 µM 0.148099593135175 0.446034726263781 no 1489 0.441132085268085 2132 5353454
SGTC_143 4032-1194 15.74 µM 0.14790307287824 0.446106632531357 no 1490 0.441209631537479 1983 1806963
SGTC_175 3793-3120 23.7 µM 0.147545431658913 0.446237497099984 no 1491 0.441350761408491 2028 5322297
SGTC_2760 etidronate 98.04 µM 0.146190509900079 0.446733329786139 no 1492 0.441885498538636 2054 3305 A chelator and antioxidant.
SGTC_970 1315-0089 19.5 µM 0.146048938631943 0.446785142513328 no 1493 0.441941377571736 2136 6811083 YLR033W RSC58
SGTC_2533 agelasine 13.65 µM 0.145008733806054 0.447165867962919 no 1494 0.442351988049441 2166 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2750 bromebric acid 70.15 µM 0.144421185620354 0.447380938062618 no 1495 0.442583944236233 2060 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_3266 9136860 49.47 µM 0.143495795177217 0.447719705572772 no 1496 0.442949315923789 2118 4871271 YPR165W RHO1
SGTC_120 rhodamine 6G 52.259 µM 0.141847499287163 0.448323209068977 no 1497 0.443600232180314 2171 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1309 pyrazolanthrone 13.4 µM 0.141143004637327 0.448581187787828 no 1498 0.443878485447058 2167 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2846 9008642 19.48 µM 0.140850715833214 0.448688227339938 no 1499 0.443993938476374 2019 2992898
SGTC_838 0109-0203 71.4 µM 0.138909003628547 0.449399399341494 no 1500 0.444761028041407 2142 759422
SGTC_486 niguldipine 82 µM 0.138169014878438 0.449670470716383 no 1501 0.445053421366437 2107 1236 A calcium channel blocker.
SGTC_39 0986-0283 58.349 µM 0.137913106268135 0.449764220179742 no 1502 0.445154546043978 2160 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_490 phenamil 164 µM 0.137746199462241 0.449825366266827 no 1503 0.445220502750643 2159 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1989 st071868 50.2 µM 0.136690149247889 0.450212276417881 no 1504 0.4456378581027 2182 16414057
SGTC_2263 7948595 193.29 µM 0.131790631081152 0.452007949599488 no 1505 0.447574948613003 2047 2971371
SGTC_639 0833-0042 114 µM 0.131398321004518 0.45215177418379 no 1506 0.447730108396367 2036 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1026 k007-1105 30.6 µM 0.129462943264196 0.452861393508381 no 1507 0.448495672566659 2120 7066794
SGTC_160 3453-0671 289.699 µM 0.128403339576015 0.453249968290796 no 1508 0.448914894218239 2127 5322268
SGTC_2914 7968218 45.32 µM 0.127474248798725 0.453590718605868 no 1509 0.449282526687026 2139 2977111
SGTC_1523 st012844 44.7 µM 0.127103725137754 0.453726620204509 no 1510 0.44942915157208 2063 4274103
SGTC_795 0685-0265 78 µM 0.125686358574199 0.454246535343458 no 1511 0.449990100255109 2216 302754
SGTC_1625 st003711 30.1 µM 0.125068495980657 0.454473202868894 no 1512 0.450234661995432 2151 24207034 YER133W GLC7
SGTC_1622 st003707 19.4 µM 0.121032329520607 0.455954262253179 no 1513 0.451832714082088 2113 10140899
SGTC_2596 sinensetin 100 µM 0.120996327588167 0.455967475841603 no 1514 0.451846971992207 2089 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_244 nsc-207895 1.295 µM 0.120731855442422 0.456064545069882 no 1515 0.45195171327501 2152 42640
SGTC_2467 5474540 200 µM 0.119585979370628 0.456485146257668 no 1516 0.452405563426967 2173 5413519
SGTC_1545 lovastatin 49.4 µM 0.118842008486467 0.456758251694875 no 1517 0.452700263269603 2103 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_301 4119-0100 24.5 µM 0.118752625189286 0.456791064926439 no 1518 0.452735671309055 2095 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2149 5554786 194.827 µM 0.118036165657512 0.457054092842306 no 1519 0.453019501061309 2072 745063 YPR165W RHO1
SGTC_2683 piperine 63.03 µM 0.11660446943596 0.457579755992795 no 1520 0.453586747895881 2126 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3295 9122362 53.5725 µM 0.116523063474272 0.457609647333354 no 1521 0.45361900429418 2058 4730473
SGTC_1304 1165-0502 251 µM 0.11636846729636 0.457666413946391 no 1522 0.453680262515809 2140 767425
SGTC_2212 7123476 200 µM 0.114864178195617 0.458218823078894 no 1523 0.454276389386085 2155 1085715
SGTC_1975 st070967 30.8 µM 0.113687079800245 0.458651136692309 no 1524 0.454742927468991 2225 261391
SGTC_2367 9070478 135.38 µM 0.113009837853848 0.458899889935169 no 1525 0.455011377851203 2142 572802
SGTC_992 3909-8734 162 µM 0.112277127124564 0.459169035170969 no 1526 0.455301838513163 2102 4288319
SGTC_1255 0566-0045 221 µM 0.111901257247458 0.459307110007481 no 1527 0.455450849863447 2116 2788469
SGTC_36 0335-0881 14.2 µM 0.110050432845545 0.459987076890342 no 1528 0.456184689076035 2146 23828853
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.109978963230917 0.460013336182479 no 1529 0.456213029302885 2201 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2195 6536160 144.242 µM 0.109453004960646 0.460206588585279 no 1530 0.456421597178824 2128 3834386
SGTC_1504 k297-0033 30 µM 0.10775999647324 0.460828712866032 no 1531 0.457093038117737 2087 4388117
SGTC_1620 st003704 16.5 µM 0.106783563925825 0.461187563031139 no 1532 0.457480343499562 2212 2834414
SGTC_1259 0671-0132 43 µM 0.106403136244756 0.46132738314081 no 1533 0.457631252421073 2117 X1259
SGTC_1274 0865-0114 173 µM 0.104898769700688 0.461880335666207 no 1534 0.45822806761004 2136 870624
SGTC_1486 3970-0793 4.53 µM 0.103678333418552 0.462328979548112 no 1535 0.458712310701894 2231 2844330
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.101677384432893 0.463064650711356 no 1536 0.459506376851964 2176 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_3038 9091290 49.47 µM 0.10015988903391 0.463622659159487 no 1537 0.460108694871309 2208 25236843
SGTC_387 norethindrone acetate 66.7 µM 0.0982533224497199 0.464323836914211 no 1538 0.46086557102988 2127 541197
SGTC_477 mead ethanolamide 10 µM 0.0961555563860279 0.465095460037467 no 1539 0.461698514029459 2239 16061185
SGTC_2848 9016370 25.97 µM 0.0956203099389242 0.465292361340245 no 1540 0.461911067056601 2235 7894410
SGTC_2600 tangeritin 87.95 µM 0.0952708287247258 0.465420929708837 no 1541 0.462049856271573 2201 68077 A bioactive flavone.
SGTC_2387 9077560 195.08 µM 0.0944902247752992 0.465708114029052 no 1542 0.462359873601426 2109 5303272
SGTC_131 0141-0277 33.849 µM 0.092855564299173 0.466309563566944 no 1543 0.463009153858616 2220 1547771
SGTC_1905 st060207 84.5 µM 0.0926865793880512 0.466371743518148 no 1544 0.463076279604012 2095 1948547
SGTC_314 1671-0008 2.74 µM 0.0919919546115572 0.466627347338529 no 1545 0.463352215888727 2179 3913060
SGTC_2582 agaric acid 100 µM 0.0916765076031887 0.466743428170154 no 1546 0.463477531495169 2201 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2967 9089538 49.85 µM 0.0913575628746251 0.466860798998153 no 1547 0.46360424030296 2257 728216
SGTC_741 4582-0002 126 µM 0.0912386295808611 0.466904566878161 no 1548 0.4636514904882 2176 2912688
SGTC_3004 9076122 71.4286 µM 0.0908154747096071 0.467060292634415 no 1549 0.463819606911499 2226 44782551
SGTC_258 haloperidol 50.781 µM 0.0894694249180358 0.467555687525242 no 1550 0.464354425746326 2091 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2160 5660466 132.927 µM 0.0892213656514006 0.467646987792494 no 1551 0.464452992878447 2258 2859134
SGTC_1934 st074720 32.6 µM 0.0891260993426642 0.467682051798916 no 1552 0.464490847826861 2234 17250992
SGTC_250 brefeldin a 552.239 µM 0.0888506289996069 0.467783443658456 no 1553 0.464600310321324 2225 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1451 4152-0210 104 µM 0.088245259048061 0.468006268390905 no 1554 0.464840873040889 2241 659563
SGTC_1776 st049249 45.9 µM 0.0881596679648076 0.468037773590001 no 1555 0.464874886378804 2132 1822314
SGTC_3174 9107204 49.47 µM 0.0879297862201581 0.468122391690663 no 1556 0.464966241153593 2208 3938802
SGTC_1885 st057546 99.9 µM 0.0877697912964465 0.468181285719177 no 1557 0.465029824065973 2231 702008
SGTC_683 panaxydol 45 µM 0.0868676376971482 0.46851338087573 no 1558 0.465388361813417 2223 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_558 k064-0027 21.3 µM 0.0849272556569133 0.469227736157002 no 1559 0.466159611590377 2209 5088526
SGTC_601 0986-0029 62.9 µM 0.0846154581436676 0.469342534294087 no 1560 0.466283554661014 2199 24747981
SGTC_71 0417-1750 47.813 µM 0.0843697485252984 0.469433001874041 no 1561 0.466381229343464 2265 6811472
SGTC_1308 1187-1617 41.4 µM 0.0839683598668547 0.469580792157387 no 1562 0.466540794034472 2231 2882570
SGTC_2259 7964009 200 µM 0.0837062737627448 0.469677293857382 no 1563 0.46664498445666 2197 313134
SGTC_1403 3909-7815 62.9 µM 0.083602753114005 0.469715411281854 no 1564 0.466686138966864 2187 6615483
SGTC_557 1315-0110 16.2 µM 0.0831151575996203 0.469894952959629 no 1565 0.466879986763444 2256 6833801
SGTC_1421 4029-0249 71.4 µM 0.082554740413726 0.470101316480557 no 1566 0.467102795143675 2275 2894095
SGTC_2441 5730946 39.09 µM 0.0816609780711831 0.470430444936669 no 1567 0.46745815483347 2216 1774275
SGTC_1618 st003135 44.5 µM 0.0787980901402341 0.471484839816007 no 1568 0.468596611586459 2265 1270615
SGTC_2141 5621638 7.665 µM 0.0779671505628773 0.471790910662043 no 1569 0.468927091738142 2255 2856238
SGTC_1603 st002045 67.8 µM 0.0762454299198991 0.472425147371591 no 1570 0.469611920002327 2276 5887985
SGTC_1872 amphotericin b 148 nM 0.0735046545521728 0.473434920703727 no 1571 0.470702270149802 2260 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_668 1682-0499 62.6 µM 0.072686909260041 0.473736232819179 no 1572 0.471027632944695 2192 682214
SGTC_1979 st071809 45.3 µM 0.0714181848824046 0.474203745502628 no 1573 0.471532468560448 2257 4976333
SGTC_2112 5488546 200 µM 0.0710382276342606 0.474343763022347 no 1574 0.471683665537974 2282 600757
SGTC_1860 st056228 74.6 µM 0.0710343098392182 0.474345206780113 no 1575 0.471685224573531 2163 688679
SGTC_291 SEC14.278 35.5 µM 0.0702024095142836 0.47465178033036 no 1576 0.472016278272126 2272 1068044
SGTC_2057 5236571 38.335 µM 0.0694165195905634 0.474941411827724 no 1577 0.472329039952816 2254 54684039 YBR257W POP4
SGTC_265 mycophenolic acid 32.932 µM 0.0693617355564378 0.474961602405041 no 1578 0.47235084306771 2251 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_380 3970-0968 6 µM 0.0687417547487779 0.475190099912849 no 1579 0.472597590655237 2255 2891601
SGTC_62 0180-0423 3.232 µM 0.0687010992343962 0.475205084023427 no 1580 0.472613771605351 2232 30102 YGL099W LSG1
SGTC_2912 7964298 10.93 µM 0.068289499648992 0.475356786293911 no 1581 0.472777591341493 2219 2975850
SGTC_1930 st074634 34.3 µM 0.0674796954437248 0.47565526429282 no 1582 0.473099912932461 2289 684253 YOR116C RPO31
SGTC_2034 5197015 53.07 µM 0.0667273841087797 0.475932563788578 no 1583 0.473399366762328 2260 780676
SGTC_504 lovastatin 124 µM 0.0653349115671526 0.476445855265339 no 1584 0.473953673151524 2172 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2297 7971671 152.32 µM 0.0645304151306497 0.476742425598426 no 1585 0.474273944900679 2251 909016
SGTC_2331 7980721 200 µM 0.0634901337247687 0.477125935003026 no 1586 0.474688107770731 2244 2981221
SGTC_922 1866-0035 480 µM 0.062664755303751 0.47743023351637 no 1587 0.475016731701644 2142 3156169
SGTC_1908 st060353 56.5 µM 0.0605157706881885 0.478222577242329 no 1588 0.475872427838309 2299 4227716
SGTC_443 clozapine 122 µM 0.059321888822781 0.478662806160042 no 1589 0.476347863527202 2305 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_311 1315-0136 58 µM 0.0593042659966488 0.478669304551759 no 1590 0.476354881661739 2281 6759207
SGTC_1391 3442-0225 151 µM 0.0587624531746055 0.47886910000726 no 1591 0.476570657391651 2276 5227075
SGTC_1554 st069299 38.7 µM 0.0572893461548514 0.479412340296422 no 1592 0.477157353476226 2246 24207999
SGTC_2589 lobaric acid 100 µM 0.0564417514023656 0.479724926715003 no 1593 0.477494948568997 2253 73157 A novel microtubule depolymerizer.
SGTC_1217 1183-1422 255 µM 0.0562357654154256 0.479800894651712 no 1594 0.477576994775221 2279 2849664
SGTC_2474 5321570 43.32 µM 0.0556243427543496 0.480026392544091 no 1595 0.477820535904938 2282 2841384
SGTC_1968 st069590 43.6 µM 0.0556158416377881 0.480029527873611 no 1596 0.477823922117927 2288 6384066
SGTC_2394 5221648 200 µM 0.0553409719797239 0.480130904274909 no 1597 0.477933410621274 2265 788586
SGTC_1388 3346-4487 254 µM 0.0545459524385523 0.480424127625495 no 1598 0.47825009915359 2260 3345614
SGTC_100 0086-0128 49.5915 µM 0.0532132599170488 0.480915682075618 no 1599 0.478780995349423 2282 93297
SGTC_2312 7706453 155.7 µM 0.0523923346634205 0.481218489187663 no 1600 0.479108040891405 2266 976098
SGTC_2218 6965428 192.983 µM 0.0521823305317718 0.481295953218668 no 1601 0.479191705971513 2285 675684
SGTC_1288 0973-0013 65.5 µM 0.0521314281420434 0.481314729642828 no 1602 0.479211985484593 2260 4315430
SGTC_2044 5102272 200 µM 0.0521157581800472 0.481320509848422 no 1603 0.4792182284086 2266 592666
SGTC_1844 rapamycin 4 nM 0.0520759871458523 0.481335180275233 no 1604 0.479234073239802 2247 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1988 st071872 53.4 µM 0.0505709437464591 0.481890367265107 no 1605 0.479833708359975 2329 16414116
SGTC_2018 5133068 143 µM 0.0497347794866085 0.482198830439549 no 1606 0.480166870360528 2317 785362
SGTC_306 1672-3436 11.6 µM 0.0495005784027995 0.482285229748057 no 1607 0.480260188133864 2275 6797378
SGTC_454 lyso-paf C-16 6.67 µM 0.0489937793241902 0.482472196242845 no 1608 0.480462126684065 2255 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2313 7726885 200 µM 0.0487358088833699 0.482567367253859 no 1609 0.48056491920408 2286 726423
SGTC_2962 9082311 13.18 µM 0.0482947261259153 0.482730094753691 no 1610 0.480740678796583 2281 16459453
SGTC_1047 2043-3044 82 µM 0.0467439377540083 0.483302245681943 no 1611 0.481358655667468 2301 669592
SGTC_1994 st072947 40.9 µM 0.046662779900879 0.483332189177862 no 1612 0.481390997674964 2252 5286565 YDL195W SEC31
SGTC_3309 9129340 25.759 µM 0.0462594512241743 0.483481000205088 no 1613 0.481551728962146 2270 17158987
SGTC_2101 5377231 179.231 µM 0.0454636233700047 0.483774633367598 no 1614 0.481868884623619 2269 2844213
SGTC_2488 5268135 45.7 µM 0.0449888074627704 0.483949828341549 no 1615 0.482058115136607 2278 1270356 YLR208W SEC13
SGTC_529 4076-0302 30.3 µM 0.0448383307491027 0.484005351063764 no 1616 0.482118086141718 2201 5816522
SGTC_13 0199-0087 65 µM 0.0444795587952366 0.484137731569891 no 1617 0.482261072783447 2331 4589825
SGTC_2106 5357045 167.29 µM 0.044381506388115 0.484173911478912 no 1618 0.482300151443237 2305 668842
SGTC_312 4092-0653 6.84 µM 0.0439061614562622 0.48434930867174 no 1619 0.482489601953562 2285 1148278
SGTC_2963 9082507 9 µM 0.0431370117049181 0.484633123098515 no 1620 0.482796157836144 2301 16459611
SGTC_3030 9087619 49.47 µM 0.0423452321522549 0.484925295998892 no 1621 0.483111743779782 2317 25236973
SGTC_523 1934-0222 13.7 µM 0.0419434397541869 0.48507356366851 no 1622 0.48327189346653 2324 1361595
SGTC_843 0310-0051 143 µM 0.040692674687266 0.485535128629976 no 1623 0.483770450756445 2292 2065037
SGTC_918 glabranin 770.725 nM 0.0400878000254862 0.485758350161279 no 1624 0.484011564076794 2292 124049 Also referred to as licorice root.
SGTC_914 3820-6779 408 µM 0.0376181440377666 0.486669791795728 no 1625 0.48499607065519 2344 2893481
SGTC_2886 9058944 51.95 µM 0.0369115063037167 0.48693059379095 no 1626 0.485277782648348 2341 4949929
SGTC_589 1227-0070 34.1 µM 0.0366351458584012 0.487032592921265 no 1627 0.485387959993901 2303 2841384
SGTC_1123 mangostin 811.285 nM 0.0338074493296841 0.488076286895989 no 1628 0.486515347818329 2243 5281650 An antioxidant.
SGTC_2125 5246583 200 µM 0.0334265231221077 0.488216891970918 no 1629 0.486667229542174 2339 835267
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.0331003849498559 0.488337275196799 no 1630 0.486797267886915 2352 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2065 5221596 34.26 µM 0.0322503847374164 0.488651029905275 no 1631 0.487136187922305 2324 788581
SGTC_2565 isoliquiritigenin 100 µM 0.0313958558182266 0.488966463343502 no 1632 0.487476923050841 2240 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1201 1889-3372 45.9 µM 0.0312704183212397 0.48901276684534 no 1633 0.487526940813021 2273 5392199
SGTC_266 formosanin C 406 nM 0.0311897422520585 0.48904254736893 no 1634 0.487559110216502 2339 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1141 3253-0389 52.6 µM 0.0306712640997829 0.489233938298604 no 1635 0.487765854151387 2332 5402031
SGTC_1070 indatraline 8.81 µM 0.0287281572040053 0.489951238116898 no 1636 0.488540699715135 2319 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2464 5717415 7.67 µM 0.0280862745340979 0.490188196989918 no 1637 0.488796670545607 2361 5285744
SGTC_1602 st001878 87.6 µM 0.0278679620035239 0.49026879053591 no 1638 0.488883730565781 2335 595405 YLR310C CDC25
SGTC_442 cape 100 µM 0.0246244947623313 0.491466213110993 no 1639 0.490177240613278 2355 5281787
SGTC_535 2293-4129 48.2 µM 0.0238482317992516 0.491752805525213 no 1640 0.490486833781119 2366 396118 YIL048W NEO1
SGTC_2473 5854593 8.94 µM 0.0233256926233134 0.491945726789295 no 1641 0.490695238768619 2356 2872951
SGTC_476 mead acid 10 µM 0.0223301597392025 0.492313282325994 no 1642 0.491092295441811 2361 5312531 An omega 9 fatty acid.
SGTC_3301 9125354 19.7965 µM 0.0220570206310102 0.492414127754723 no 1643 0.491201235347386 2349 41905162
SGTC_3176 9106582 49.47 µM 0.0219776107986037 0.492443446674203 no 1644 0.491232907609316 2351 17018027
SGTC_182 3448-4371 550.524 µM 0.0201640497645085 0.493113042690512 no 1645 0.491956253091551 2368 3491403
SGTC_2330 7979373 200 µM 0.0199369252042547 0.493196902151508 no 1646 0.492046844469663 2353 1863007
SGTC_169 k015-0017 16.025 µM 0.0191388188425718 0.493491583207677 no 1647 0.492365182068092 2352 1840002
SGTC_1563 conessine 56.1 µM 0.0190978902911288 0.493506695161235 no 1648 0.49238150721395 2370 441082 An anti-amoebic, histamine inhibitor.
SGTC_2994 9053520 71.4286 µM 0.0184043732675958 0.493762762233015 no 1649 0.492658131835706 2370 4647384
SGTC_2222 6885208 172.143 µM 0.0182223963978039 0.493829953925203 no 1650 0.492730717930035 2372 609514
SGTC_416 estradiol valerate 100 µM 0.0179884018320414 0.493916352474764 no 1651 0.492824052956369 2342 13791 A steroid.
SGTC_3062 9077494 49.47 µM 0.0176284623973576 0.49404925460015 no 1652 0.492967625246392 2343 16459633
SGTC_3143 9086658 49.47 µM 0.0174742269690649 0.494106203873634 no 1653 0.493029146803235 2341 25236626
SGTC_2275 7947463 200 µM 0.0174367921398886 0.494120026178593 no 1654 0.493044078864318 2375 1225414
SGTC_2281 7943571 200 µM 0.0143856449703099 0.495246643291947 no 1655 0.4942611559304 2383 1244024
SGTC_548 1436-0017 110 µM 0.0130360491137604 0.495744985793701 no 1656 0.494799516133353 2386 9677137
SGTC_121 0557-0495 61.343 µM 0.012935321586663 0.495782180024825 no 1657 0.494839697214724 2381 3104427
SGTC_1487 3970-0795 2.82 µM 0.0125592215868649 0.495921057480651 no 1658 0.494989727215516 2357 3765103
SGTC_304 1310-0298 97 µM 0.0114080678380759 0.496346131749106 no 1659 0.495448938117493 2384 1550234
SGTC_2251 lansoprazole 556 µM 0.0112242347929607 0.496414014213869 no 1660 0.495522272196063 2368 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_16 erodoxin 22.806 µM 0.0109403889252352 0.496518827766091 no 1661 0.49563550335983 2381 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2954 9074818 52.69 µM 0.0106695279606932 0.496618846708445 no 1662 0.495743554942826 2374 16648742
SGTC_667 1498-1044 59 µM 0.00971646310209571 0.496970779980177 no 1663 0.496123753045233 2367 6739982
SGTC_1711 st032263 62.8 µM 0.00964279687929877 0.49699798242234 no 1664 0.496153140239385 2374 3958979
SGTC_1506 4226-2149 212 µM 0.00887288229984905 0.497282286623062 no 1665 0.496460278547515 2341 991114
SGTC_514 4466-0038 2.65 nM 0.00813250451227319 0.497555685158966 no 1666 0.496755635866964 2350 5722064
SGTC_2874 9043904 71.43 µM 0.00735461386334906 0.497842937264567 no 1667 0.497065960024447 2367 4463428
SGTC_1231 0242-0792 125 µM 0.0069606126868221 0.497988430730648 no 1668 0.497223139724953 2383 3707635
SGTC_2017 5132927 60.65 µM 0.00638915659064174 0.498199453738679 no 1669 0.497451112641391 2387 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_3316 9136639 10.545 µM 0.00562379788210223 0.498482080423384 no 1670 0.497756441074615 2355 4903665
SGTC_827 3253-0474 693 µM 0.00540422143865687 0.498563164330783 no 1671 0.497844038069837 2399 5402065
SGTC_1358 1509-0022 2.48 µM 0.00521087839569218 0.498634560970426 no 1672 0.497921169697767 2391 3258434
SGTC_2092 5303694 80.6725 µM 0.00478042163825371 0.498793517792668 no 1673 0.498092894954022 2393 1963699
SGTC_432 NS 1619 61.3 µM 0.00373690284606215 0.499178863705112 no 1674 0.498509194926665 2367 4552 A K+/calcium channel activator.
SGTC_1055 3448-0672 86 µM 0.00336024618865472 0.499317953983508 no 1675 0.498659458245521 2390 748378
SGTC_2516 gossypol 71.55 µM 0.00302653412697859 0.499441185921512 no 1676 0.498792589416966 2396 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_902 1120-0002 2.07 µM 0 0.499441185921512 no 1677 0.5 2405 3280475
SGTC_1659 st012954 42.1 µM 0 0.499441185921512 no 1678 0.5 2405 24207262
SGTC_2224 6650123 117.647 µM 0 0.499441185921512 no 1679 0.5 2405 2908370
SGTC_199 4063-0024 41.6 µM -0.000735085212424264 0.499169736499666 no 1680 0.499706743455476 2412 306215
SGTC_1932 st074806 40.9 µM -0.000738529433052426 0.499168464632012 no 1681 0.499705369410618 2415 17251235
SGTC_260 nsc-65238 3.989 µM -0.000888922635021793 0.499112928056179 no 1682 0.499645371223588 2408 3246252
SGTC_1728 st035614 33.7865 µM -0.00173790650848563 0.498799419177721 no 1683 0.49930667596339 2425 15945546
SGTC_2175 5807670 165.306 µM -0.00199417031074545 0.498704787390728 no 1684 0.499204441676007 2411 241186
SGTC_2495 cafestol 54.53 µM -0.0022306990656741 0.498617443325691 no 1685 0.499110080565893 2422 16667697 An anti-infammatory.
SGTC_2951 9072950 58.06 µM -0.00234938453497987 0.498573615819353 no 1686 0.499062732038301 2412 16488155
SGTC_2655 perillic acid 100 µM -0.00277594152532505 0.498416099385441 no 1687 0.498892560979919 2411 5702197 An apoptosis inducer.
SGTC_2242 6630449 61.2675 µM -0.00313484176688138 0.498283567024477 no 1688 0.498749381125177 2439 691249 YDR170C SEC7
SGTC_3017 9080681 49.47 µM -0.00346136899271092 0.498162989325665 no 1689 0.49861911631815 2416 16451914
SGTC_2968 9090663 33.37 µM -0.00434655532911226 0.49783611475877 no 1690 0.49826598076512 2434 25236811
SGTC_631 k072-0230 41.5 µM -0.00587497794644247 0.497271714561146 no 1691 0.497656236383389 2420 5773147
SGTC_1347 1493-0251 600 nM -0.00642803187092559 0.49706748977752 no 1692 0.497435603966899 2414 3986378
SGTC_2437 5741531 144.16 µM -0.00655192014661588 0.497021741979779 no 1693 0.497386180736571 2419 2262990
SGTC_3160 9100216 49.47 µM -0.00960720054178945 0.495893542983934 no 1694 0.49616734046567 2425 17191039
SGTC_68 0986-0284 82.829 µM -0.00964015998263644 0.495881372477225 no 1695 0.496154192160059 2493 423278 YIL048W NEO1
SGTC_2207 7258803 200 µM -0.00976901689431452 0.495833791187864 no 1696 0.496102788110553 2425 3666799
SGTC_89 0302-0250 142.109 µM -0.0100452613309336 0.495731786255 no 1697 0.495992587933694 2417 4203518 YLR208W SEC13
SGTC_1368 1852-0141 284 µM -0.0110033194472213 0.495378019692358 no 1698 0.49561039922497 2410 2838987
SGTC_1475 4092-1048 11.7 µM -0.0116338784456517 0.49514518537678 no 1699 0.495358858697406 2440 2881759
SGTC_2541 muurolladie-3-one 83.07 µM -0.0143200598571754 0.494153330658061 no 1700 0.49428731791011 2523 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.0144463415914935 0.494106702804538 no 1701 0.494236943997939 2453 5282362
SGTC_1527 coumarin 137 µM -0.0149459244277514 0.493922239271627 no 1702 0.494037660805453 2478 323 A hepatotoxic, DNA x-linker.
SGTC_2978 9011784 42.97 µM -0.015630990213808 0.493669291038718 no 1703 0.493764391042365 2450 2994934
SGTC_2572 astragaloside iv 100 µM -0.0160391378266948 0.493518591069361 no 1704 0.493601584117207 2499 45006101 An anti-inflammatory agent.
SGTC_781 4335-2806 94.4 µM -0.0162153170104936 0.493453540875221 no 1705 0.493531307931525 2480 845254
SGTC_2764 methyldopa 94.69 µM -0.0176685025654159 0.492916991649925 no 1706 0.492951654017905 2449 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1511 0906-3109 28.5 µM -0.0177052766952952 0.492903413965235 no 1707 0.49293698555719 2431 2882180
SGTC_991 3996-0057 64.7 µM -0.017918473323729 0.49282469801379 no 1708 0.492851945899263 2449 715343
SGTC_1286 0929-0070 131 µM -0.0180944000318641 0.492759742983839 no 1709 0.492781772674343 2458 1420408
SGTC_830 4076-0286 57.8 µM -0.0183690575187006 0.492658335313363 no 1710 0.49267221839977 2454 6866659
SGTC_1591 genipin 88.4 µM -0.0186039218074739 0.492571620265536 no 1711 0.492578537114209 2479 442424 A DNA cross-linking agent.
SGTC_1961 st076550 68.7 µM -0.0197953986023661 0.492131716533847 no 1712 0.492103294274448 2465 1579337
SGTC_574 1315-0397 40 µM -0.0204774971719283 0.491879884004369 no 1713 0.491831231484051 2445 6794277
SGTC_2365 9042475 200 µM -0.0207903299907909 0.491764386407253 no 1714 0.491706455811391 2455 6464479
SGTC_851 0394-0702 453 µM -0.0238175178042966 0.490646788486244 no 1715 0.490499083412881 2439 762646
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.0246386871135656 0.490343635871882 no 1716 0.490171580401641 2444 77254
SGTC_594 1487-1584 10.8 µM -0.0262371795085494 0.489753533591497 no 1717 0.489534080560995 2449 5013332
SGTC_1709 st033179 39.1045 µM -0.0264220417278264 0.489685290949874 no 1718 0.489460356764662 2445 573381
SGTC_491 tetrandrine 80.3 µM -0.0267078790702593 0.489579773525142 no 1719 0.489346364392977 2460 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1804 st050076 49.1 µM -0.028599737573029 0.488881408923559 no 1720 0.488591910693177 2478 3895976
SGTC_952 1185-0122 232 µM -0.0292914907063332 0.48862606212401 no 1721 0.488316056712342 2447 678600
SGTC_2673 kobusone 100 µM -0.0294813200593543 0.488555991235202 no 1722 0.488240358449559 2470 6710676 An epoxy ketone and protein crosslinker.
SGTC_1818 st052136 56.3 µM -0.0313847383352245 0.487853410559923 no 1723 0.48748135610027 2478 674169
SGTC_540 1187-0821 17.3 µM -0.0338292914715516 0.486951144360518 no 1724 0.486506639045902 2463 847520
SGTC_1059 3448-6867 171 µM -0.0348313267412979 0.486581319706716 no 1725 0.486107120326846 2453 3934407
SGTC_2197 6588183 93.1375 µM -0.0350989178002526 0.486482560879943 no 1726 0.486000432176147 2468 884136
SGTC_1649 st011737 51.3 µM -0.0352212286378084 0.48643742035435 no 1727 0.485951667363323 2491 1761035
SGTC_1260 0700-1617 7.75 µM -0.0353074221901856 0.486405609522439 no 1728 0.485917302485248 2491 2853078
SGTC_2499 avocadenofuran 51.48 µM -0.0355264384745035 0.486324779153678 no 1729 0.485829982412047 2476 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1052 3253-3998 198 µM -0.0359495982293049 0.486168608986002 no 1730 0.485661273867937 2462 5450317
SGTC_2361 9034121 116 µM -0.0367353685122614 0.485878620425299 no 1731 0.485348003835548 2498 6496917
SGTC_1478 0453-0656 35.7 µM -0.0372884095933438 0.485674525056068 no 1732 0.485127523435881 2480 5258496
SGTC_1442 4112-3290 3 µM -0.0379569071066517 0.485427826432142 no 1733 0.484861020198123 2456 704353
SGTC_899 1083-0020 478 µM -0.0387284595315603 0.485143103932908 no 1734 0.484553441500183 2538 767123
SGTC_1352 1496-0991 99 µM -0.0401202794516893 0.484629506181162 no 1735 0.483998617076177 2477 3000039
SGTC_1035 k081-0041 55.2 µM -0.0402322221816633 0.484588199107319 no 1736 0.483953994416179 2475 731709
SGTC_3223 9129970 49.47 µM -0.0405569975809137 0.484468357323524 no 1737 0.483824533443771 2498 17248386
SGTC_269 exalamide 29 µM -0.0412233853245749 0.484222465345212 no 1738 0.483558905361551 2495 3316 A derivative of salicylamide.
SGTC_2436 5633522 8.09 µM -0.0419482574016749 0.483954999911436 no 1739 0.483269973193315 2495 5724242
SGTC_652 0437-0092 114 µM -0.0434183143707041 0.483412596255476 no 1740 0.482684039355218 2487 3091274
SGTC_3157 9099274 49.47 µM -0.0435162250186622 0.483376471460312 no 1741 0.482645015541347 2490 17217662
SGTC_118 0083-0097 135.343 µM -0.0440627767852613 0.483174820008189 no 1742 0.482427181886319 2485 5207356
SGTC_48 0382-0018 55 µM -0.0448593399388679 0.482880934037181 no 1743 0.48210971311271 2485 762596
SGTC_2669 eugenol 100 µM -0.045712791703341 0.482566069767519 no 1744 0.481769584081799 2468 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2842 9000675 19.48 µM -0.0470121497215754 0.482086718086031 no 1745 0.481251772079427 2543 2989072
SGTC_1327 1436-0082 2.18 µM -0.0472278061829249 0.482007161832553 no 1746 0.481165833056971 2545 15992205
SGTC_1906 st060206 94.7 µM -0.0473704767451368 0.481954530668815 no 1747 0.481108979369952 2477 5133468
SGTC_1452 4194-0072 190 µM -0.0480959193512108 0.481686919809848 no 1748 0.480819899164958 2502 1343545
SGTC_1291 0993-0025 5.79 µM -0.0494581211994483 0.481184435173796 no 1749 0.480277105386248 2529 4353356
SGTC_3318 9139014 38.6185 µM -0.049677786223936 0.48110340862413 no 1750 0.4801895793117 2488 16643984
SGTC_2165 5727197 32.143 µM -0.0505425922805953 0.480784420302879 no 1751 0.479845004512782 2778 1361712
SGTC_1223 0764-0573 147 µM -0.0510561822467457 0.480594985717846 no 1752 0.479640375963092 2512 1609797
SGTC_774 k060-0086 136 µM -0.0511760014667962 0.480550791744541 no 1753 0.479592637417939 2494 5911235
SGTC_2343 7990716 14.84 µM -0.0511997546129846 0.480542030691779 no 1754 0.479583173690181 2506 6456862
SGTC_1041 0206-0046 107 µM -0.0513230761054422 0.480496545243125 no 1755 0.479534040130147 2595 50494
SGTC_593 1203-0218 61.7 µM -0.0517757266469532 0.480329593452539 no 1756 0.479353698466313 2511 3666956
SGTC_2819 7996655 46.38 µM -0.051938828787478 0.480269437085037 no 1757 0.479288717557863 2510 6456960
SGTC_1321 1326-2144 215 µM -0.0526765281653396 0.479997359747028 no 1758 0.478994820432577 2542 3513030
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.0530226799861899 0.479869695681166 no 1759 0.47885691855656 2503 5106787 A p450 inhibitor.
SGTC_1057 3448-5381 134 µM -0.0532936927681683 0.479769745044143 no 1760 0.47874895275194 2554 5497911
SGTC_3243 9134147 49.47 µM -0.0534204640121047 0.479722991720346 no 1761 0.478698450283724 2497 24282180
SGTC_3277 9138724 49.47 µM -0.0536294542908605 0.4796459165681 no 1762 0.478615194571475 2527 15943418
SGTC_1992 st073643 23.3 µM -0.0536347986321653 0.479643945596823 no 1763 0.478613065551932 2490 3161292
SGTC_2816 7982706 58.44 µM -0.0536452629471458 0.479640086401576 no 1764 0.478608896895705 2564 2981853
SGTC_2014 4013930 200 µM -0.055152117833656 0.479084384777264 no 1765 0.478008637633994 2502 64556
SGTC_2892 9047358 58.44 µM -0.055279329325205 0.479037473258634 no 1766 0.47795796489532 2534 6466771
SGTC_1977 st070720 65.3 µM -0.0553371813850611 0.479016139370195 no 1767 0.47793492053599 2591 682188
SGTC_3279 9140807 49.47 µM -0.0553867381069477 0.478997864570417 no 1768 0.477915180538564 2490 45595718
SGTC_2069 5228469 200 µM -0.0558641929743907 0.478821798047002 no 1769 0.477724998065063 2566 2835210
SGTC_3085 9117376 49.47 µM -0.0560175246113752 0.478765256262013 no 1770 0.477663923230183 2572 16480349
SGTC_3073 9114972 49.47 µM -0.0566697083756247 0.478524765123362 no 1771 0.477404152218983 2510 41905075
SGTC_1769 st044406 64.4 µM -0.0573739866903717 0.47826507303217 no 1772 0.477123642236605 2515 670903
SGTC_845 0330-0138 4.51 µM -0.0587670410409815 0.477751432366793 no 1773 0.476568830255322 2504 9039800
SGTC_3142 9086498 49.47 µM -0.0590018378259822 0.477664862779955 no 1774 0.476475322145251 2513 25236367
SGTC_1448 4255-0083 152 µM -0.0594684737149619 0.477492817236023 no 1775 0.476289487675763 2603 5399660
SGTC_2192 5915882 198.485 µM -0.0599029722325118 0.477332624297508 no 1776 0.476116456324536 2505 2876149
SGTC_3199 9111318 49.47 µM -0.0610522056627243 0.476908937283868 no 1777 0.47565881622824 2562 8548020
SGTC_3291 9121177 71.43 µM -0.0613923101171164 0.476783556217288 no 1778 0.475523388223499 2559 17015612
SGTC_3066 9117245 49.47 µM -0.0617922435663626 0.47663612185871 no 1779 0.475364140211276 2545 17176980
SGTC_3355 9151058 44.0485 µM -0.0622066089577855 0.476483370578276 no 1780 0.475199149749009 2507 17015728
SGTC_1100 amiodarone 5.07 µM -0.062647953083747 0.476320677682647 no 1781 0.475023421672904 2520 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1657 st012939 43.4 µM -0.0632107317640467 0.476113226038748 no 1782 0.474799349579502 2572 24207257
SGTC_3280 9140961 49.47 µM -0.0635393146869084 0.475992106694333 no 1783 0.474668526941114 2523 4901226
SGTC_695 3505-6186 243 µM -0.0653049313994307 0.475341318867353 no 1784 0.473965608019619 2582 1819379
SGTC_836 0330-0104 1.35 µM -0.0679572451354618 0.474363827976516 no 1785 0.472909834501275 2533 46494820
SGTC_366 0181-0206 4.31 µM -0.0679736388462457 0.474357786667709 no 1786 0.472903309444928 2545 274874
SGTC_2820 7989630 71.43 µM -0.0685956829812387 0.474128559183286 no 1787 0.472655727628182 2532 2984098
SGTC_362 0310-0100 9.03 µM -0.0688125873183152 0.474048630473516 no 1788 0.472569399304101 2591 790235
SGTC_2476 5806916 10.51 µM -0.0694486766774389 0.473814239159337 no 1789 0.47231624201715 2565 2870194
SGTC_2709 st078560 56 µM -0.069474015584846 0.473804902262498 no 1790 0.472306157613027 2557 17250903
SGTC_2823 7987624 58.44 µM -0.0731628470863227 0.472445795428367 no 1791 0.470838265426591 2610 2239440
SGTC_1044 1222-0021 1.78 µM -0.0740630915777358 0.472114158958078 no 1792 0.470480091612735 2678 4306703
SGTC_1522 st012842 45.6 µM -0.0750267003103861 0.471759201485615 no 1793 0.47009673399136 2532 3491067 YOR116C RPO31
SGTC_3019 9081971 49.47 µM -0.075331957720575 0.471646760720051 no 1794 0.46997529756504 2582 16451803
SGTC_399 oxolinic acid 75 µM -0.0758524447520456 0.47145504590513 no 1795 0.469768245695916 2547 4628 A DNA gyrase inhibitor.
SGTC_2478 5763493 32.33 µM -0.0770348563200864 0.471019544209836 no 1796 0.469297908005623 2560 1365576 YLR208W SEC13
SGTC_1149 3909-7961 23.3 µM -0.0805460089513787 0.469726534996623 no 1797 0.467901502612048 2565 735261
SGTC_332 4112-0506 40.9 µM -0.0805765701748117 0.469715281970237 no 1798 0.467889349948068 2552 2790355
SGTC_793 0488-0545 106 µM -0.081896414725715 0.46922932182608 no 1799 0.467364542749134 2546 292548
SGTC_1210 3013-0140 750 nM -0.0828264285044517 0.468886922902302 no 1800 0.466994777208433 2636 905973
SGTC_2079 5212404 121 µM -0.0830164395623648 0.468816970221897 no 1801 0.466919233927213 2558 758462
SGTC_2354 9060492 162 µM -0.0830634886122947 0.46879964923568 no 1802 0.466900528675552 2620 6471895
SGTC_804 1595-0054 20.9 µM -0.0835230841124305 0.468630453450349 no 1803 0.466717811525795 2564 761523 Stimulates phospholipase C.
SGTC_760 0568-0725 82.9 µM -0.0835704917300692 0.468613001101091 no 1804 0.466698964514313 2591 3916171
SGTC_3167 9103034 49.47 µM -0.0840318231044379 0.46844317255604 no 1805 0.466515565031066 2553 5127859
SGTC_1922 5578187 25 µM -0.0850481569136846 0.468069052921477 no 1806 0.466111552843118 2680 1350412
SGTC_3008 9078912 71.4286 µM -0.0854382078597306 0.467925479890574 no 1807 0.465956509358746 2588 16648731
SGTC_1924 st058459 75.1 µM -0.0859141091466707 0.46775031204092 no 1808 0.465767347752784 2548 688683
SGTC_435 c-PAF 6.7 µM -0.0860697967489246 0.467693008522477 no 1809 0.465705466602925 2557 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_3052 9092717 49.47 µM -0.0865848100041492 0.467503453750893 no 1810 0.465500770205585 2671 25237534
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0866182055062492 0.467491162521638 no 1811 0.465487497193868 2795 6710655
SGTC_897 1000-0139 31.4 µM -0.0875567937199535 0.467145727436617 no 1812 0.465114471925844 2546 6151020
SGTC_2067 5224629 34.075 µM -0.0888068894361021 0.466685684567046 no 1813 0.464617691174852 2658 2835000
SGTC_101 0490-5701 117.494 µM -0.0898034425774882 0.466318978765367 no 1814 0.464221706232696 2565 4661669
SGTC_1313 1220-0047 237 µM -0.089918104702453 0.466276787894879 no 1815 0.464176146979491 2604 3528706
SGTC_2347 9049783 174.81 µM -0.09088641465838 0.46592050545543 no 1816 0.463791422522396 2642 6467988 YPL169C MEX67
SGTC_2009 4012297 12.05 µM -0.0920549435938034 0.465490590325399 no 1817 0.463327193095585 2643 45595307
SGTC_776 4476-4378 112 µM -0.0923905665703991 0.465367118225136 no 1818 0.463193867079131 2660 2892008
SGTC_1960 st011366 51.8 µM -0.093081977026617 0.465112766242158 no 1819 0.462919217757561 2567 3972846
SGTC_822 1487-0950 154 µM -0.0933673061199059 0.465007805214255 no 1820 0.462805881483758 2567 1958375
SGTC_626 0214-0009 33 µM -0.0934081649559511 0.46499277510089 no 1821 0.462789652091508 2650 3437874
SGTC_2753 fluvastatin 17.09 µM -0.0938029779200283 0.464847543887229 no 1822 0.462632833039929 2643 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1594 piperine 70.1 µM -0.0953605602153263 0.464274636001882 no 1823 0.46201422082977 2592 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2357 9067248 200 µM -0.0954543285350878 0.464240148612708 no 1824 0.46197698255095 2638 9150235
SGTC_2434 5670830 169.91 µM -0.0956457356190516 0.464169751143867 no 1825 0.461900969955922 2659 1549830
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.0962713329710314 0.463939670995729 no 1826 0.46165253914325 2578 688669
SGTC_1870 st057514 26.5 µM -0.0980453370097767 0.46328729942964 no 1827 0.460948146519158 2569 5393161
SGTC_1012 4112-3522 18 µM -0.0985428824197013 0.463104349921307 no 1828 0.460750611196107 2576 3112398
SGTC_948 3448-0295 75.3 µM -0.0986779065158488 0.463054702346388 no 1829 0.46069700564042 2584 678569
SGTC_879 0831-1030 162 µM -0.0987255851539711 0.463037171325865 no 1830 0.460678077042255 2594 1549252
SGTC_309 k408-0051 1.48 µM -0.0992626214522979 0.462839712716337 no 1831 0.460464877781368 2602 3640463
SGTC_2438 5259590 200 µM -0.100077037464577 0.462540284050664 no 1832 0.460141582622977 2671 1201127
SGTC_2177 5811945 192 µM -0.103681897553165 0.461215176306741 no 1833 0.458710896439721 2702 5343475
SGTC_1574 spiramycin 23.7 µM -0.103853244517137 0.46115220160972 no 1834 0.458642905929418 2567 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2143 5623677 140.463 µM -0.103927159737183 0.461125036044818 no 1835 0.458613576728418 2571 5375313
SGTC_2194 5927483 104.545 µM -0.104475233765535 0.460923611742133 no 1836 0.458396110650282 2571 760979
SGTC_2448 5185112 27.17 µM -0.10513414459283 0.460681466756113 no 1837 0.458134682980558 2702 5718189
SGTC_1653 st012112 65 µM -0.106230983241758 0.460278418824709 no 1838 0.457699544476477 2705 720429
SGTC_6 0844-0013 19.835 µM -0.107100023208773 0.45995910750057 no 1839 0.457354814378185 2635 1584900
SGTC_1025 k007-0731 70 µM -0.107626291120331 0.459765753441157 no 1840 0.457146070413367 2591 6256118
SGTC_1939 st074455 53.6 µM -0.107827189080203 0.459691944805165 no 1841 0.457066387429819 2692 1644229
SGTC_907 3448-6986 75.5 µM -0.109726720330861 0.458994138087892 no 1842 0.456313054302724 2673 590582
SGTC_1085 doxorubicin 7.67 µM -0.111293764612053 0.458418567892694 no 1843 0.45569169990407 2628 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2341 7987486 176.74 µM -0.111689812362484 0.458273114612657 no 1844 0.4555346786713 2654 1258686
SGTC_2905 7799065 20.05 µM -0.112697125224204 0.457903192121376 no 1845 0.455135340234774 2662 1296806
SGTC_892 0929-0076 29 µM -0.11546391337481 0.456887313882053 no 1846 0.454038711042256 2620 5751038
SGTC_2084 5306078 60.6385 µM -0.116181488357174 0.456623888482559 no 1847 0.453754353771314 2688 679340
SGTC_933 2914-0560 114 µM -0.117147955727499 0.456269123576519 no 1848 0.453371404075841 2733 463887
SGTC_1473 k844-0725 134 µM -0.117284347455747 0.45621906053894 no 1849 0.453317364170947 2632 54682906
SGTC_2611 pyromycin 23.93 µM -0.117513912069323 0.45613479965361 no 1850 0.453226410095173 2670 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_687 k029-0044 34.9 µM -0.118031921349619 0.455944673419799 no 1851 0.453021182541069 2649 5829338
SGTC_1941 st076221 61.8 µM -0.11943696280741 0.455429028472677 no 1852 0.452464589391995 2783 2828568
SGTC_324 1315-0088 19.6 µM -0.119819621553659 0.455288607118891 no 1853 0.452313019085485 2649 6787421
SGTC_3024 9090631 49.47 µM -0.121459784155233 0.454686792691084 no 1854 0.451663433206504 2623 25236383
SGTC_3103 9120822 49.47 µM -0.122391112869025 0.454345112374235 no 1855 0.451294638250543 2811 17141819
SGTC_3312 9133330 71.43 µM -0.122619256481799 0.454261417549535 no 1856 0.451204302524829 2774 17617324
SGTC_492 tmb-8 126 µM -0.123188262649784 0.454052685644672 no 1857 0.450979009911591 2603 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2332 7982454 138.89 µM -0.124175087209303 0.453690713063681 no 1858 0.450588323539435 2623 2981748
SGTC_3313 9133968 57.047 µM -0.125529906223268 0.453193820844668 no 1859 0.4500520252728 2609 1494643
SGTC_3122 9126309 49.47 µM -0.125690095157749 0.453135074922238 no 1860 0.449988621302108 2608 17591206
SGTC_1378 2093-0007 380 nM -0.12715634391329 0.452597406850245 no 1861 0.44940832866986 2713 3618014
SGTC_3308 9128332 17.569 µM -0.129896229428914 0.451592934505384 no 1862 0.448324263747287 2769 17332805 YDL196W YDL196W
SGTC_363 0455-0021 3.06 µM -0.130335052860985 0.45143208559895 no 1863 0.448150674207419 2649 4597466
SGTC_1455 4262-0120 131 µM -0.132283941854328 0.450717825136978 no 1864 0.447379854147192 2837 1529587
SGTC_310 1273-0058 1.06 µM -0.132777303804319 0.450537035062781 no 1865 0.447184752174847 2682 2734232
SGTC_1710 st031758 61.5 µM -0.132900597668753 0.450491856230379 no 1866 0.447135997113215 2794 5394341
SGTC_654 1124-0271 80.9 µM -0.132931405982222 0.450480567174846 no 1867 0.447123814464458 2672 5403748
SGTC_1695 st026914 34.495 µM -0.133959838433374 0.450103742879414 no 1868 0.446717166204209 2627 3289191
SGTC_1570 verbenone 133 µM -0.134434100710923 0.449929985250293 no 1869 0.446529658948627 2750 29025 A natural terpanoid with antifungal properties.
SGTC_1247 0448-0043 5.84 µM -0.135106797365925 0.449683542785905 no 1870 0.446263717968793 2746 3089013 YGL099W LSG1
SGTC_84 0443-0269 128.823 µM -0.135154654778292 0.449666010957958 no 1871 0.446244799146322 2644 6150058
SGTC_1678 st019265 80.2 µM -0.135285465716635 0.449618090881298 no 1872 0.446193088054746 2713 5367020
SGTC_2402 5553605 200 µM -0.137934051627344 0.448647991261224 no 1873 0.445146269155465 2799 6758546
SGTC_707 0865-0008 204 µM -0.138420492925243 0.448469855222708 no 1874 0.444954050950655 2669 723043
SGTC_3262 9137218 49.47 µM -0.138589024147924 0.448408141082399 no 1875 0.444887458533669 2609 17650664
SGTC_2045 5106652 78.05 µM -0.139703746365471 0.447999974500844 no 1876 0.444447033133518 2757 673349
SGTC_1361 1608-0041 5.61 µM -0.139764831572061 0.44797760913444 no 1877 0.444422900419462 2656 X1361
SGTC_1569 carminic acid 40.6 µM -0.140981234126909 0.447532277420853 no 1878 0.443942383630542 2718 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1831 st055328 12 µM -0.141494820502622 0.447344270427202 no 1879 0.443739525759571 2714 1103068
SGTC_2325 6158266 200 µM -0.14247109765582 0.446986920290185 no 1880 0.443353953599135 2742 3623240
SGTC_1356 1502-0781 85.8 µM -0.143495043571501 0.446612168034653 no 1881 0.442949612699856 2653 567702
SGTC_2740 felodipine 17.08 µM -0.145228776848366 0.445977750758034 no 1882 0.442265123073503 2750 3333 L-type calcium channel blocker
SGTC_3089 9117425 49.47 µM -0.14576683387612 0.4457808899932 no 1883 0.442052729463668 2730 9401657
SGTC_2135 5326629 150.42 µM -0.146079147588384 0.445666628834889 no 1884 0.441929453817488 2713 5020077
SGTC_743 1275-0778 158 µM -0.146723497489546 0.44543090524503 no 1885 0.441675135505408 2780 2849257 YMR203W TOM40
SGTC_2522 biochanin a 4.94 µM -0.147449686944196 0.445165265281584 no 1886 0.441388544781153 2775 5280373 A possible chelator.
SGTC_2659 sanguinarine 24.21 µM -0.148106599775471 0.444924987899336 no 1887 0.441129320511722 2661 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1382 3002-2117 298 µM -0.149835232076545 0.444292807238841 no 1888 0.440447305972883 2745 1497314
SGTC_272 doxorubicin 8.13 µM -0.149979892570272 0.444239909640066 no 1889 0.440390239607144 2636 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2491 paeonol 100 µM -0.15139853438433 0.443721211625447 no 1890 0.439830672764456 2656 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1990 st072050 59.8 µM -0.151684992843417 0.443616485487009 no 1891 0.439717697088154 2632 17233948
SGTC_2583 asiatic acid 100 µM -0.152460088441425 0.443333138617037 no 1892 0.439412033599194 2814 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1499 4480-0877 67.3 µM -0.154623378500306 0.442542471868059 no 1893 0.438559119138709 2681 2861909
SGTC_433 pimozide 108 µM -0.154960513498262 0.442419272010839 no 1894 0.438426223436529 2660 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2861 9024595 19.48 µM -0.155419990218189 0.442251373563371 no 1895 0.438245112866722 2732 16482810
SGTC_1720 st037298 9.481 µM -0.155905302117818 0.442074045887969 no 1896 0.438053832966068 2775 597396
SGTC_2 0422-0095 29 µM -0.156383057919326 0.441899490465645 no 1897 0.437865545347173 2624 6790840
SGTC_2531 methyl deoxycholate 70.07 µM -0.157174603999383 0.441610311790271 no 1898 0.437553621294679 2693 16667744 Haematoxylin.
SGTC_31 0508-1974 57.237 µM -0.157713044121618 0.441413619095956 no 1899 0.437341460707856 2727 6810525
SGTC_1632 st005650 90 µM -0.158672556483361 0.441063144152534 no 1900 0.436963430484931 2809 2759605
SGTC_1351 1496-0003 46.5 µM -0.158699628253075 0.441053256488521 no 1901 0.436952765538748 2797 3891978
SGTC_736 0958-0254 92.6 µM -0.159049201986569 0.440925581857409 no 1902 0.436815054794405 2794 6812352
SGTC_431 k089-0097 107 µM -0.159276473826138 0.440842578775478 no 1903 0.436725527647885 2684 5499420
SGTC_1459 k035-0031 35.7 µM -0.159851900493765 0.440632435960484 no 1904 0.436498869509341 2668 3877128 YMR208W ERG12
SGTC_3096 9117468 49.47 µM -0.160061798764068 0.440555786366173 no 1905 0.436416196650969 2757 41316311
SGTC_157 1348-1695 65.819 µM -0.161205573757116 0.440138147578537 no 1906 0.43596574565628 2695 5380510
SGTC_2374 9071832 200 µM -0.161979767837046 0.439855495584501 no 1907 0.435660893191279 2687 17381698
SGTC_257 daunorubicin 18.5 µM -0.163143921493313 0.439430530249101 no 1908 0.435202559335264 2818 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3034 9090421 49.47 µM -0.163856694815757 0.439170372247118 no 1909 0.434921979382808 2667 17173761
SGTC_510 ag-490 170 µM -0.164642923543262 0.438883433939488 no 1910 0.434612522059385 2750 5328779
SGTC_2645 abamectin 100 µM -0.165020731904683 0.438745562206705 no 1911 0.43446383203258 2753 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2284 7945075 39.21 µM -0.168220529331209 0.437578175666434 no 1912 0.433204895505628 2826 1245402
SGTC_1111 tnp00062 510.699 nM -0.169730648618172 0.437027424780236 no 1913 0.432610984833558 2837 676306
SGTC_2433 5607874 27.82 µM -0.172167977228027 0.436138772124092 no 1914 0.431652736199117 2713 2252428
SGTC_1613 st002381 52.1 µM -0.173616431907124 0.435610816355382 no 1915 0.431083458676123 2717 551167
SGTC_2791 5663188 71.43 µM -0.176312909038872 0.434628267860004 no 1916 0.430024060477027 2868 54690634
SGTC_1911 st060208 74.3 µM -0.180685013579669 0.433036010751336 no 1917 0.42830741130042 2827 688783
SGTC_1332 1480-0653 17.5 µM -0.180746947731905 0.433013462974637 no 1918 0.42828310333495 2688 5749438
SGTC_2670 beta-carotene 100 µM -0.181212621926203 0.432843936396755 no 1919 0.428100343876679 2788 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_3314 9135860 59.4275 µM -0.181608144395022 0.432699957941679 no 1920 0.42794512842017 2749 25252478
SGTC_2567 aureobasidin a 60 nM -0.181920153397332 0.43258638643906 no 1921 0.427822694139596 2995 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3240 9133527 49.47 µM -0.18202824892896 0.432547040885798 no 1922 0.42778027839833 2755 17617455
SGTC_1700 st030840 7.9285 µM -0.183130829129387 0.43214575241059 no 1923 0.427347683326004 2846 5499307
SGTC_3179 9107801 49.47 µM -0.18355131804469 0.431992732201731 no 1924 0.427182728343502 2754 4818259
SGTC_2622 2-methoxyxanthone 59.94 µM -0.184434571878433 0.431671340364417 no 1925 0.426836275276663 2804 71034 A hepatoprotective.
SGTC_3306 9127676 59.7925 µM -0.185601530233443 0.431246785615102 no 1926 0.426378626732584 2802 41905287
SGTC_2849 9019321 12.99 µM -0.185609614036365 0.431243844898052 no 1927 0.426375456835337 2857 16489627
SGTC_1342 1486-1464 234 µM -0.185851258921988 0.43115594134444 no 1928 0.426280702954616 2744 3253938
SGTC_568 1193-0097 7.48 µM -0.186225594133684 0.431019775549031 no 1929 0.426133926898554 2791 3646150
SGTC_837 0091-0265 12.5 µM -0.190145259224448 0.429594478508062 no 1930 0.424597652619273 2744 759367
SGTC_411 enrofloxacin 100 µM -0.19015569990558 0.429590683208525 no 1931 0.424593562015066 2893 71188 A bacterial gyrase inhibitor.
SGTC_808 0711-0032 135 µM -0.191262726303893 0.429188304235852 no 1932 0.424159881035037 2705 4252555
SGTC_3298 9116858 71.43 µM -0.19154906488095 0.429084238620244 no 1933 0.424047721945964 2879 2506942
SGTC_2779 methotrexate 400 µM -0.192865309229223 0.428605932158085 no 1934 0.423532227068942 2772 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_705 1124-0212 310 µM -0.193129404445073 0.428509975920174 no 1935 0.423428812362734 2803 9554485
SGTC_3058 9093861 49.47 µM -0.1934978411794 0.428376115343287 no 1936 0.423284548299095 2915 17217477
SGTC_853 0419-0306 21 µM -0.195413461510636 0.427680264565315 no 1937 0.422534639497377 2750 762713
SGTC_745 0469-0705 296 µM -0.195925905947592 0.427494156707548 no 1938 0.422334080103209 2913 3486736
SGTC_3246 9135460 32.98 µM -0.196203630393166 0.427393300410052 no 1939 0.422225393321187 2844 41446951
SGTC_2036 5160441 105 µM -0.197141955109109 0.427052580678006 no 1940 0.421858226093344 2805 134534 YIL048W NEO1
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.202613150902281 0.425066999254805 no 1941 0.419718705134057 2770 65057 A dermal irritant. YDR527W RBA50
SGTC_3140 9094243 49.47 µM -0.202824306878798 0.424990405236722 no 1942 0.419636179322722 2720 19291112
SGTC_2924 9010168 62.78 µM -0.203884813980818 0.424605763290024 no 1943 0.419221756255273 2857 2993929
SGTC_2274 7947094 46.08 µM -0.204721670182864 0.424302289338194 no 1944 0.418894794311056 2749 2971028
SGTC_3018 9082602 49.47 µM -0.205025000218417 0.424192302103127 no 1945 0.418776296278165 2754 17332089
SGTC_2061 5245884 80.95 µM -0.206805262951169 0.423546899498848 no 1946 0.418080972882602 2760 573863
SGTC_1400 3771-8998 51.5 µM -0.207978405819089 0.423121709384662 no 1947 0.417622914172588 2784 670767
SGTC_570 0987-0065 62.6 µM -0.208212766151111 0.423036779295543 no 1948 0.417531420539186 2729 3104428
SGTC_2202 7226349 200 µM -0.208330558320439 0.422994093816796 no 1949 0.417485436483619 2751 844334
SGTC_1186 1319-0216 26 µM -0.20874719745506 0.422843119552501 no 1950 0.417322796724115 2941 4565136
SGTC_2814 7977482 42.97 µM -0.209228348530858 0.422668782701266 no 1951 0.417134991605771 2938 6456762
SGTC_290 2043-6722 48.1 µM -0.210618295168061 0.422165244533833 no 1952 0.416592567529415 2857 773758 YLR208W SEC13
SGTC_2981 9013952 38.96 µM -0.211607248610916 0.421807052202919 no 1953 0.416206726909595 2837 2996344
SGTC_600 1495-0418 41.6 µM -0.214927165601629 0.420605075112627 no 1954 0.414912052351026 2794 5377768
SGTC_215 1287-0124 461.5 µM -0.214973284803192 0.420588382824477 no 1955 0.414894073627181 2856 5560863
SGTC_1572 epiandrosterone 68.9 µM -0.215183876033581 0.420512163686496 no 1956 0.414811980768876 2774 441302 A steroid.
SGTC_1627 st003713 25.6 µM -0.215502961506092 0.420396682982192 no 1957 0.414687601679475 2862 16195070 YER133W GLC7
SGTC_737 1950-0117 57.9 µM -0.218553603486838 0.419292967813588 no 1958 0.413498899016134 2863 5393513
SGTC_1097 itavastatin 7.23 µM -0.221344991268665 0.418283606075897 no 1959 0.412411910333919 2827 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2857 9024691 58.44 µM -0.221920992577424 0.418075391576782 no 1960 0.412187694127193 2912 16478292
SGTC_503 tyrphostin 8 294 µM -0.222308632612353 0.417935279337448 no 1961 0.412036816192584 2920 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1381 2324-0066 62.1 µM -0.222498663121489 0.417866596736481 no 1962 0.411962856932089 2921 10885928
SGTC_2187 6125751 200 µM -0.222511537498227 0.417861943649613 no 1963 0.411957846379313 2835 874498
SGTC_2534 helenine 20.12 µM -0.222591784553341 0.417832940833515 no 1964 0.411926615513003 2777 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.223301378168135 0.41757649963342 no 1965 0.41165047736122 2817 17037758
SGTC_2393 9031399 185.94 µM -0.226237653688072 0.41651572796876 no 1966 0.41050829314734 2960 1526623 YDL150W RPC53
SGTC_1843 st055809 45.5 µM -0.226863369976804 0.41628975726605 no 1967 0.410264992979511 2939 16413835
SGTC_969 1313-0238 134 µM -0.227106459659693 0.416201975501401 no 1968 0.410170480599689 2816 5212874
SGTC_1477 0139-0234 16 µM -0.228521386111905 0.415691116556438 no 1969 0.409620466107415 2796 620880
SGTC_725 1497-0963 19 µM -0.228630533655178 0.415651714762561 no 1970 0.409578045318082 2942 3549977
SGTC_1120 ficusin 1.78878 µM -0.22923640978957 0.415433011512346 no 1971 0.409342587506932 2951 6199 A DNA cross-linker.
SGTC_3270 9137563 49.47 µM -0.234353185352469 0.413587059132444 no 1972 0.407355399677582 2932 17015724
SGTC_1670 st016595 4.04 µM -0.234762955661499 0.413439310428012 no 1973 0.407196360670959 2840 597879
SGTC_812 4251-0442 148 µM -0.234796452315248 0.413427233259047 no 1974 0.407183360711255 2854 5723007
SGTC_469 w7 172 µM -0.236083768604648 0.412963155441214 no 1975 0.406683834379323 2832 45115570 A P450 inhibitor.
SGTC_2273 7815444 169.05 µM -0.236307772954391 0.412882414225073 no 1976 0.406596927889246 3021 2824616
SGTC_1401 3807-4679 7.6 µM -0.237321696441363 0.412516996858688 no 1977 0.406203615750913 2805 3291456
SGTC_565 1418-0001 44.5 µM -0.239811449775549 0.411620013644063 no 1978 0.405238215155207 3005 2862145
SGTC_1158 4092-0494 91.8 µM -0.240693271775845 0.411302430185633 no 1979 0.404896427019196 2961 1148199
SGTC_1103 duloxetine 36.1 µM -0.241014542385713 0.411186740732629 no 1980 0.404771922756997 3001 60835 A selective serotonin reuptake inhibitor.
SGTC_116 0155-0182 31.788 µM -0.241883459034303 0.41087388281992 no 1981 0.404435233697809 2854 771486
SGTC_2349 9023730 187.07 µM -0.242829131389728 0.410533453045689 no 1982 0.404068883644347 2971 4126287
SGTC_2773 thioridazine 9.09 µM -0.243847300477628 0.410167000735246 no 1983 0.403674542665356 2812 5452 An antipsychotic.
SGTC_245 methotrexate 289.6 µM -0.246509017980833 0.409209385251873 no 1984 0.402644112226454 2915 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2923 7992654 58.14 µM -0.246883723373817 0.409074619527276 no 1985 0.402499106677527 2884 2985126
SGTC_2375 9072683 200 µM -0.247914740203876 0.408703861775924 no 1986 0.402100187416472 3007 16798029
SGTC_2969 9091408 28.7 µM -0.248660390973906 0.408435773675908 no 1987 0.40181174500819 2835 4286311
SGTC_2238 6671620 73.2395 µM -0.249426542909388 0.408160359303926 no 1988 0.401515427773599 2777 729941
SGTC_1753 st043925 64 µM -0.249859528907695 0.40800473064049 no 1989 0.401347990963359 2958 670181
SGTC_328 k915-0120 63.5 µM -0.250436950406239 0.407797209942198 no 1990 0.401124728759508 2968 6624543
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.250463942279791 0.407787509909704 no 1991 0.4011142930389 3127 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2980 9014342 25.29 µM -0.2504985343011 0.407775078705201 no 1992 0.401100919017833 3024 2996599
SGTC_1794 st048918 76.9 µM -0.250590651281025 0.407741975425714 no 1993 0.401065305173065 2857 672303
SGTC_1183 1254-0324 198 µM -0.251273832053692 0.407496487253958 no 1994 0.400801202628887 2992 5799357
SGTC_561 1550-0330 72.9 µM -0.25161105485244 0.4073753259622 no 1995 0.400670856473298 2858 6812934
SGTC_1115 galangin 695.678 nM -0.252219044153903 0.40715690295928 no 1996 0.40043587935468 2930 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_624 k048-0052 28 µM -0.252523849617677 0.407047411029582 no 1997 0.400318090984762 2903 6835531
SGTC_571 k831-0106 44.2 µM -0.252697194057039 0.406985145644087 no 1998 0.400251108174592 2908 4783639
SGTC_165 k038-0023 64.381 µM -0.252733918770091 0.406971954415571 no 1999 0.40023691758842 2866 46368543
SGTC_3149 9097855 49.47 µM -0.254024418537727 0.406508484147442 no 2000 0.399738346721606 3011 25236625 YMR079W SEC14
SGTC_3310 9130229 44.1445 µM -0.25517303968188 0.40609607830285 no 2001 0.399294726581545 3013 7761258
SGTC_222 nsc-310342 10.666 µM -0.256166397816517 0.405739502735103 no 2002 0.398911176890803 2875 432556
SGTC_938 3126-1755 342 µM -0.256495918049285 0.405621235499003 no 2003 0.398783965984601 3019 1777771
SGTC_698 k064-0052 127 µM -0.258510567459288 0.404898350732518 no 2004 0.398006447189093 2843 5088751
SGTC_1827 berberine 7.24 µM -0.260022233252434 0.404356156506052 no 2005 0.397423311827318 2871 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1629 st005085 44.9 µM -0.260741544908007 0.40409822300676 no 2006 0.397145912854936 2868 24207091
SGTC_1443 4112-3303 14 µM -0.261065104110564 0.403982213508395 no 2007 0.397021150808584 2881 704433
SGTC_1200 1643-0193 18.4 µM -0.261882103493806 0.403689322684062 no 2008 0.396706168788501 2893 5403974
SGTC_3287 9117173 37.0625 µM -0.262321877488296 0.403531687912426 no 2009 0.396536648319831 2933 2789709
SGTC_2799 7812892 81.82 µM -0.262950505182759 0.403306386699229 no 2010 0.396294364039767 3042 20205235
SGTC_1414 3917-0015 5.4 µM -0.26511354111767 0.402531396641821 no 2011 0.395460998082545 2951 6618702
SGTC_1422 4031-0024 15.5 µM -0.265655976129645 0.402337108556716 no 2012 0.395252085645016 2930 782427
SGTC_1298 1079-1278 263 µM -0.266447948539676 0.402053485093481 no 2013 0.3949471209016 2907 2840950
SGTC_2682 pyrogallin 40.03 µM -0.267790036436833 0.401572970482444 no 2014 0.394430470246028 2909 822798 An ATP competetive kinase inhibitor.
SGTC_739 1486-1183 203 µM -0.268428424584235 0.401344457274746 no 2015 0.394184781210974 3005 4346692
SGTC_862 0452-0056 10.2 µM -0.268496011164383 0.401320266402305 no 2016 0.394158772411288 2936 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1437 4092-1038 11.6 µM -0.26947716679203 0.400969129708659 no 2017 0.393781255401813 2892 3977136
SGTC_1132 3456-3614 2.5 µM -0.271122833286638 0.40038035710197 no 2018 0.393148280316151 3150 3125502
SGTC_1727 st034309 9.9045 µM -0.273708019198142 0.399455908655428 no 2019 0.392154507296164 3154 870305
SGTC_232 clozapine 119 µM -0.275411053981258 0.398847220174087 no 2020 0.391500226251822 2872 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_987 1497-1013 404 µM -0.277267613901412 0.398183939868334 no 2021 0.390787312698575 2881 1676435
SGTC_2746 daunorubicin 9.88 µM -0.278093590836015 0.397888943219838 no 2022 0.390470257771304 2914 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2051 5263410 176 µM -0.278716608920998 0.397666471683386 no 2023 0.390231157669728 2933 227584
SGTC_2005 4024620 188 µM -0.278853376797279 0.397617638131583 no 2024 0.390178674838859 2885 236743
SGTC_3063 1327-0034 4 µM -0.279237020075513 0.39748066523219 no 2025 0.390031467581519 2984 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_606 k015-0008 38.6 µM -0.280347729421272 0.397084177861347 no 2026 0.389605367746479 3039 1970475
SGTC_1682 st012968 530 nM -0.281520680995456 0.396665587476625 no 2027 0.389155534044081 2907 24207270
SGTC_1063 disulfiram 1.84 µM -0.281607574520497 0.396634582577547 no 2028 0.389122215777035 2900 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1903 st060211 78.3 µM -0.282115216389127 0.396453461494032 no 2029 0.388927582968605 3068 688960
SGTC_1133 3473-0247 50 µM -0.283043058402046 0.396122475345199 no 2030 0.388571915071222 2961 711311
SGTC_2471 5466956 24.79 µM -0.285047682723571 0.395407627954594 no 2031 0.387803805512183 2923 724419
SGTC_3322 9139058 2.11 µM -0.285119837389208 0.395381904204654 no 2032 0.387776166257306 3099 4908926 YPR165W RHO1
SGTC_348 k064-0012 10.7 µM -0.286808434720093 0.394780035327502 no 2033 0.38712950209173 2863 5066323
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.287416123520059 0.394563497392444 no 2034 0.386896858500511 2943 4330530
SGTC_206 4546-0025 72.014 µM -0.290394143534426 0.393502810752066 no 2035 0.385757361776226 2980 6620745 YIL048W NEO1
SGTC_526 4469-0568 170 µM -0.293001683572762 0.39257472684005 no 2036 0.384760432418079 2914 2901964
SGTC_2334 9017922 200 µM -0.293651387084308 0.392343577116401 no 2037 0.38451215236749 3057 3163164
SGTC_459 nigericin 15.3 µM -0.298231713153225 0.390715083369624 no 2038 0.382763159429392 3057 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1102 cgs 12066b 26.1 µM -0.298393269726403 0.390657678179664 no 2039 0.382701512607704 2968 6438352 A 5-HT1B full agonist.
SGTC_2691 st077356 60.2 µM -0.299148279222045 0.390389435571459 no 2040 0.382413455202613 3097 2839272
SGTC_2628 lathosterol 100 µM -0.29992734441517 0.390112701053193 no 2041 0.382116288067797 3101 6710616
SGTC_155 k072-0202 43.6 µM -0.302702242400524 0.389127472926034 no 2042 0.3810583943663 2912 5857737
SGTC_1213 1315-0166 115 µM -0.303232532746542 0.388939274114165 no 2043 0.380856328944269 3049 768401
SGTC_1909 st060837 51.5 µM -0.303835622837499 0.388725270512389 no 2044 0.380626562904 2983 678937
SGTC_2257 7960413 200 µM -0.305302976358777 0.388204728345908 no 2045 0.380067704640212 2933 2974689 YIL048W NEO1
SGTC_796 1234-0020 70.7 µM -0.305479830795414 0.388142002953576 no 2046 0.380000364498829 2926 46495034
SGTC_64 000l-0018 272.079 µM -0.30736659766612 0.387473000690896 no 2047 0.379282174804716 2892 6811119
SGTC_147 4466-0538 29.23 µM -0.307500351960075 0.387425587282402 no 2048 0.379231277585742 3162 6742687 YHR072W ERG7
SGTC_1510 1123-0200 71.5 µM -0.307650623604213 0.387372320783499 no 2049 0.379174097553955 3134 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_3218 9131285 49.47 µM -0.307877076430323 0.387292054493837 no 2050 0.379087934728868 3122 17156417
SGTC_959 1222-0044 107 µM -0.309615530038557 0.386676019671476 no 2051 0.378426672498292 3092 6083612
SGTC_699 0375-0592 111 µM -0.313937379612647 0.385145777937686 no 2052 0.376784299841814 3090 762578
SGTC_1074 carmofur 3.8 µM -0.315438012264528 0.38461486408275 no 2053 0.376214554623571 2975 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2800 7887935 81.82 µM -0.321936598294488 0.382318216272135 no 2054 0.373750363261163 3142 2961002
SGTC_2781 5567276 71.43 µM -0.322289704702392 0.382193543575329 no 2055 0.3736166159247 3126 2853274
SGTC_180 1486-1293 102.781 µM -0.322718043447336 0.3820423246897 no 2056 0.373454393006401 3107 4140536
SGTC_453 enantio-paf c16 10 µM -0.325456985755173 0.381075806459163 no 2057 0.372417616221427 3087 13871343 A lipid and platelet activating factor
SGTC_3065 9113888 49.47 µM -0.325913371014888 0.380914829087452 no 2058 0.372244949484253 3171 16648368
SGTC_1081 sertraline 6 µM -0.328138103586915 0.380130411326437 no 2059 0.371403622522959 3089 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3113 9123498 49.47 µM -0.329025230645768 0.37981775672518 no 2060 0.371068308760038 3034 8897275
SGTC_3212 9128307 49.47 µM -0.329500791972552 0.379650184606792 no 2061 0.370888597717812 2916 27243542
SGTC_784 4579-0127 173 µM -0.329781079961974 0.379551430952093 no 2062 0.370782692184798 3188 1948547
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.330502936840237 0.379297135852983 no 2063 0.370509986955879 3131 756377
SGTC_723 4182-0001 115 µM -0.330885886648271 0.379162251826083 no 2064 0.370365341445164 3003 744821 YLR208W SEC13
SGTC_2351 9026858 72.31 µM -0.331198418890242 0.379052181440985 no 2065 0.370247307217438 2940 1409300
SGTC_2877 9040724 71.43 µM -0.331651830081914 0.378892512489218 no 2066 0.370076088879131 3184 6463895
SGTC_505 gw-5074 63.9 µM -0.332228999111699 0.37868929205832 no 2067 0.369858174025998 3095 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2338 7999974 200 µM -0.332307180995061 0.378661766901422 no 2068 0.369828659032899 3043 315925
SGTC_3120 9124077 49.47 µM -0.332339868865607 0.378650258806941 no 2069 0.369816319032116 3018 18774327 YGL155W CDC43
SGTC_1742 st038235 28.8875 µM -0.332582384724622 0.378564882014268 no 2070 0.369724771037101 3106 564103 YBR002C RER2
SGTC_53 0973-0023 39.979 µM -0.332785829566874 0.378493264596826 no 2071 0.369647977765237 3084 674768
SGTC_1780 st038448 24.544 µM -0.334011985000241 0.37806171720831 no 2072 0.369185257411144 3168 728868 YDL195W SEC31
SGTC_2150 5556613 200 µM -0.334208575459129 0.377992541012523 no 2073 0.369111086703122 3024 743190
SGTC_440 fluspirilene 35.1 µM -0.334260616604648 0.377974229443497 no 2074 0.369091453154845 3209 3396 An atypical antipsychotic.
SGTC_1146 3579-1023 7 µM -0.335836172123399 0.377419973201369 no 2075 0.368497205677526 3115 X1146
SGTC_2472 5377652 49.4 µM -0.336531672247486 0.377175387158072 no 2076 0.368234985945552 3033 1610903
SGTC_357 1325-0123 420 µM -0.340249990391728 0.375868606812897 no 2077 0.366834137292652 3124 1098503
SGTC_898 1000-0849 28.3 µM -0.34034404724965 0.375835569483348 no 2078 0.366798724968236 3096 6751807
SGTC_2493 resveratrol 26.09 µM -0.341124500830951 0.375561471469686 no 2079 0.366504928633948 2964 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_3013 9080133 71.4286 µM -0.342094237127415 0.375220984207898 no 2080 0.366139987111995 3228 17050193
SGTC_1252 0493-0875 34.8 µM -0.342137695952287 0.375205727512336 no 2081 0.366123635054426 2983 3960963
SGTC_1865 st057639 52.2 µM -0.342201742622221 0.375183243584566 no 2082 0.366099536943718 2977 688818
SGTC_3027 9089541 49.47 µM -0.343475180862024 0.374736284379868 no 2083 0.365620504609575 3104 9943819
SGTC_971 1315-0384 26.7 µM -0.343742560714589 0.374642459099198 no 2084 0.365519950272151 3027 6769120
SGTC_1762 st045503 25.4615 µM -0.344659190037716 0.374320864433489 no 2085 0.365175300937996 3085 4645554
SGTC_1314 1222-0010 41.1 µM -0.344704830065981 0.374304854148262 no 2086 0.365158143294367 3069 3526027
SGTC_1172 0370-0043 85 µM -0.345300118409806 0.3740960499452 no 2087 0.364934378830107 3148 376585
SGTC_2862 9027634 71.43 µM -0.346275953651359 0.373753844479636 no 2088 0.364567669135849 2978 5012562
SGTC_3082 9117008 49.47 µM -0.347843395146592 0.373204383161898 no 2089 0.363978898840802 3032 41448529
SGTC_2710 st078562 53.7235 µM -0.349560015084915 0.372602923583305 no 2090 0.363334461624152 2984 17250908
SGTC_1795 st049545 62.3 µM -0.349954558344954 0.372464729581708 no 2091 0.363186400502379 3144 5291882
SGTC_1465 k213-0056 144 µM -0.35155162810356 0.371905502660514 no 2092 0.362587273658148 3010 24048857 YMR208W ERG12
SGTC_1834 st055981 52.8 µM -0.351649925324019 0.371871091904999 no 2093 0.362550409282172 3181 471719 YDL150W RPC53
SGTC_2748 diazoxide 86.69 µM -0.35194887856883 0.371766444097198 no 2094 0.362438300771986 3086 3019 A potassium channel activatior.
SGTC_2068 5226020 147 µM -0.352552013725273 0.371555347045884 no 2095 0.362212158894958 3064 1810509
SGTC_2919 7978188 46.38 µM -0.353561606786389 0.371202076359802 no 2096 0.3618337257246 3210 2980291
SGTC_2445 5742597 35.57 µM -0.35364793953968 0.371171872357326 no 2097 0.361801371249246 3012 1774255
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.357481742559999 0.369831397180538 no 2098 0.360365595894854 2992 6312947
SGTC_1829 berberine 14.4 µM -0.357934723290327 0.369673118194802 no 2099 0.360196082244599 3193 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_509 pifithrin 175 µM -0.358319927226918 0.369538538916127 no 2100 0.360051953527316 3138 4817 A p53 inhibitor.
SGTC_1320 1313-0481 95.3 µM -0.358668754804526 0.369416682289584 no 2101 0.359921452627842 3206 6813365 YLR208W SEC13
SGTC_1417 3966-0327 90.4 µM -0.359387742045926 0.369165558450951 no 2102 0.35965252174134 3090 651118
SGTC_1902 st060212 70.5 µM -0.360596869838877 0.368743366997502 no 2103 0.359200414808017 3107 688944
SGTC_1315 1237-0019 3.69 µM -0.36155613709081 0.36840853203777 no 2104 0.358841873805277 3174 825140
SGTC_651 3253-0966 34.4 µM -0.362106973670879 0.368216306103773 no 2105 0.358636046273068 3053 781462
SGTC_865 0488-0499 301 µM -0.362713748957196 0.368004597371918 no 2106 0.358409364004912 3202 9634651
SGTC_132 0417-1715 25.805 µM -0.363835870527064 0.367613185869752 no 2107 0.357990287472229 3201 6769098
SGTC_2872 9044037 25.97 µM -0.363851027708724 0.367607899775544 no 2108 0.357984627919331 3024 6465195
SGTC_1267 0828-0272 9.49 µM -0.363947182601305 0.367574366169114 no 2109 0.35794872528966 3188 745334
SGTC_1737 st035557 69.7 µM -0.364272258547617 0.367461004804851 no 2110 0.357827356670413 3062 5716916
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.365411185447472 0.367063926304171 no 2111 0.357402246456975 3116 4213774
SGTC_2144 5628481 200 µM -0.365537997326112 0.367019723061714 no 2112 0.357354924218384 3065 2818399
SGTC_2052 5265182 7.135 µM -0.365917551832788 0.366887431008943 no 2113 0.357213299423199 3187 1239884
SGTC_2805 7950783 58.44 µM -0.366070308290297 0.366834192878148 no 2114 0.357156306303147 3157 1178958 YDL195W SEC31
SGTC_2887 9044784 58.44 µM -0.366171610740938 0.366798888725046 no 2115 0.357118512324654 3048 6465546
SGTC_2745 rifampicin 24.3 µM -0.368064812700991 0.366139310766469 no 2116 0.356412453694043 3097 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2056 5235370 200 µM -0.368523649222139 0.365979514863209 no 2117 0.356241407249956 3058 5511916
SGTC_463 ikarugamyin 104 µM -0.369343163925167 0.36569416585043 no 2118 0.355935978095056 3124 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_764 1951-2361 146 µM -0.369504070822278 0.365638147969599 no 2119 0.355876019725526 3057 5438930
SGTC_2560 caryophyllene 100 µM -0.372311165530647 0.364661352290814 no 2120 0.354830593169301 3046 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1785 bathophenanthroline 24 µM -0.372427384130417 0.364620930136495 no 2121 0.354787334185646 3073 72812 An iron chelator.
SGTC_3271 9137798 49.47 µM -0.376124781616415 0.36333572097525 no 2122 0.353412065838185 3170 6498326
SGTC_3191 9110352 49.47 µM -0.377870229531652 0.362729539326383 no 2123 0.352763499505446 3118 17122424
SGTC_800 3448-7362 155 µM -0.379179669865679 0.362275005662349 no 2124 0.352277223713645 3150 15991913
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.381214953258567 0.36156890246442 no 2125 0.351521877149813 3130 676296 Flavone; oxidizing agent.
SGTC_863 0466-0191 129 µM -0.381770838428199 0.361376130401148 no 2126 0.351315675456306 3193 765160 YPR165W RHO1
SGTC_1766 st045414 44.774 µM -0.38190591988351 0.361329291631069 no 2127 0.351265574546816 3094 253960
SGTC_2570 licareol 100 µM -0.382313739461836 0.361187894992399 no 2128 0.351114332370835 3138 443158
SGTC_2749 bexarotene 57.39 µM -0.382433741909507 0.361146292108714 no 2129 0.351069833279597 3141 82146 An retinoic acid receptor inhibitor.
SGTC_2619 obliquin 87.91 µM -0.383436474269937 0.36079872545767 no 2130 0.350698081751515 3042 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1914 st062367 72.6 µM -0.383456826921151 0.360791672019816 no 2131 0.35069053771803 3063 978205
SGTC_1121 fusaric acid 630.51 nM -0.384027781728308 0.360593820579559 no 2132 0.3504789282515 3074 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2296 7971656 126.45 µM -0.38491116579278 0.360287777407967 no 2133 0.350151616491533 3149 666570
SGTC_2404 5161160 200 µM -0.385977614469033 0.359918431844302 no 2134 0.349756623844063 3039 2831543
SGTC_2179 6298986 200 µM -0.388621677950088 0.359003272015973 no 2135 0.348778014114262 3205 738374
SGTC_2085 5307070 144.047 µM -0.3896217710928 0.358657331551193 no 2136 0.348408125473087 3070 2840351
SGTC_75 0159-0059 199.013 µM -0.389969990575591 0.358536906756537 no 2137 0.348279368843932 3366 5377270
SGTC_1923 st058458 19.1 µM -0.394229620553289 0.357064939934467 no 2138 0.34670575939134 3294 3534982
SGTC_1799 st045822 46.1415 µM -0.395231097595017 0.356719175117403 no 2139 0.346336172218263 3234 3674992
SGTC_696 1560-0013 611 µM -0.395973295281501 0.356463003674189 no 2140 0.346062364382766 3288 1650269
SGTC_1759 st043059 70 µM -0.397303068340944 0.356004191063889 no 2141 0.345571992496048 3070 669426
SGTC_1907 st060210 83.7 µM -0.398132520173102 0.355718110183149 no 2142 0.34526625197856 3236 688793
SGTC_3166 9102297 49.47 µM -0.399591431729043 0.355215123613555 no 2143 0.34472873417555 3149 25237072
SGTC_2808 7946468 45.46 µM -0.400034874073318 0.355062288643935 no 2144 0.344565415399382 3149 2970879
SGTC_1633 st005664 67.9 µM -0.400150619044678 0.35502240030608 no 2145 0.344522791564058 3055 2063822
SGTC_458 nppb 133 µM -0.401118206406169 0.35468900998976 no 2146 0.344166548527582 3293 4549 A chloride channel blocker.
SGTC_253 dyclonine 31.25 µM -0.401360295598971 0.35460561352693 no 2147 0.344077438558022 3151 3180 An oral anasthetic.
SGTC_2888 9058547 12.99 µM -0.401699315542245 0.354488837441054 no 2148 0.343952664158137 3092 16476514
SGTC_3213 9129884 49.47 µM -0.404639883410593 0.353476527894489 no 2149 0.342871118679147 3170 17190742
SGTC_3069 9117009 49.47 µM -0.405600777382945 0.353145958046867 no 2150 0.34251797878966 3132 41904981
SGTC_2428 5615643 7.78 µM -0.406142616274399 0.35295960171402 no 2151 0.342318907251484 3204 2253075
SGTC_2950 9072895 21.46 µM -0.406661909894487 0.352781032540891 no 2152 0.342128159950061 3241 17332245
SGTC_908 3448-7491 47.7 µM -0.407275179617876 0.352570189627259 no 2153 0.341902945153049 3094 1203031
SGTC_2223 6903751 107.57 µM -0.408971015791411 0.351987394908695 no 2154 0.341280465867612 3191 5598863
SGTC_3055 9094636 49.47 µM -0.40931440268074 0.351869428095503 no 2155 0.341154473623149 3302 25236176
SGTC_714 4296-0578 26.1 µM -0.410263343247634 0.351543504109008 no 2156 0.34080638951351 3115 1589775
SGTC_2063 5246145 200 µM -0.414146433248891 0.350210953456239 no 2157 0.339383434451164 3242 711240
SGTC_1246 0422-0085 105 µM -0.414594363648378 0.350057356447932 no 2158 0.339219437488326 3274 264295
SGTC_1155 4088-0394 48.2 µM -0.416103868211244 0.349539922422053 no 2159 0.338666999761126 3115 2326248
SGTC_373 0844-0104 25.9 µM -0.419285821624668 0.348450115956184 no 2160 0.337503628655609 3270 5375804
SGTC_2592 piperlongumine 83.33 µM -0.421503947536021 0.347691155251606 no 2161 0.33669356461842 3190 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2188 6126565 140.678 µM -0.421987519155601 0.34752577580068 no 2162 0.336517063686163 3245 874518
SGTC_2525 harmine 47.85 µM -0.422725186371636 0.347273552630969 no 2163 0.336247888666183 3149 5280953 A monoamine oxidase inhibitor
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.422830629590763 0.347237505007588 no 2164 0.336209419252053 3155 6708784 An antioxidant flavonoid
SGTC_372 0155-0182 15.9 µM -0.425531039553161 0.346314793952046 no 2165 0.335224799620428 3117 771486
SGTC_358 0075-0058 9.45 µM -0.426517421539611 0.345977981138888 no 2166 0.334865428074247 3381 1069125
SGTC_1266 0828-0227 32.9 µM -0.426813277900908 0.345876980918021 no 2167 0.334757667283066 3211 3913820
SGTC_1816 st051957 91.6 µM -0.42893282131559 0.345153726693746 no 2168 0.333986056994797 3190 674121
SGTC_2205 7238770 200 µM -0.429924704158527 0.344815459354291 no 2169 0.333625207160375 3281 279867
SGTC_2264 7948757 110.76 µM -0.430295618036839 0.344688996368634 no 2170 0.333490307129982 3087 2971411
SGTC_1688 st021091 57.6 µM -0.43081148879631 0.344513139227855 no 2171 0.333302722604847 3273 3656366
SGTC_27 0485-0001 32.618 µM -0.4314945764749 0.344280330586314 no 2172 0.333054397646026 3211 2054479
SGTC_1950 st077106 7.18 µM -0.431804567511778 0.344174699487188 no 2173 0.332941729789143 3218 13831864
SGTC_1583 clindamycin 39.6 µM -0.432810640475427 0.343831958546561 no 2174 0.332576171268791 3152 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_3029 9088683 49.47 µM -0.433019283847269 0.343760895634863 no 2175 0.332500380217961 3286 25236615
SGTC_58 0957-0393 9 µM -0.433146231795414 0.343717660485713 no 2176 0.332454268907138 3288 6997992
SGTC_966 1300-0360 30.2 µM -0.434799869375471 0.343154661708604 no 2177 0.331853849871421 3162 70588
SGTC_234 nsc-17383 10.7 µM -0.437095307622362 0.34237373189262 no 2178 0.331021115091071 3310 408974
SGTC_1365 1672-3266 55.4 µM -0.437269942785995 0.34231434688338 no 2179 0.330957795412395 3279 6415873
SGTC_1999 st074831 12.5 µM -0.440300398615327 0.341284456761785 no 2180 0.329859776034012 3174 17112523
SGTC_138 0850-0259 40.9225 µM -0.441172733450537 0.340988215303275 no 2181 0.329543975618847 3280 6813004
SGTC_2767 sibutramine 71.45 µM -0.442046217263221 0.340691681852724 no 2182 0.329227881006579 3371 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_719 2810-4230 27.3 µM -0.443209833763822 0.340296806021845 no 2183 0.328806983334849 3231 721079
SGTC_391 gliotoxin 8.33 µM -0.443758708722354 0.34011060482595 no 2184 0.328608522264723 3341 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2261 9010538 184.68 µM -0.44824887897423 0.33858882009856 no 2185 0.326986795118739 3280 6457250
SGTC_1457 k015-0032 57.3 µM -0.448724351435689 0.33842782915697 no 2186 0.326815257893016 3241 4302660
SGTC_2181 6316240 54.2555 µM -0.450942536760394 0.337677161026795 no 2187 0.326015482476547 3269 12779990
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.45110562919731 0.337621993463202 no 2188 0.32595671037717 3210 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.451601822589215 0.337454172802647 no 2189 0.325777928389162 3193 390807
SGTC_1853 st056710 91.2 µM -0.451953955542308 0.337335095329832 no 2190 0.325651076694682 3340 269167
SGTC_1418 3966-3099 2.4 µM -0.453367648336376 0.33685720428535 no 2191 0.325142014060478 3291 740335
SGTC_2576 guaiol 23.12 µM -0.453974569848013 0.336652118544371 no 2192 0.324923565144224 3231 227829
SGTC_1809 st050081 57.6 µM -0.455596728561328 0.336104211049498 no 2193 0.324339998029106 3360 5036894
SGTC_2640 pentamidine 10.38 µM -0.456526576072996 0.335790298487715 no 2194 0.324005682271091 3285 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1969 st069479 40.1 µM -0.456714959255078 0.335726715073551 no 2195 0.323937968586587 3317 3895485
SGTC_153 4077-0274 519.67 µM -0.457662219605668 0.335407065444621 no 2196 0.323597567458432 3457 3121976
SGTC_543 3844-1095 191 µM -0.45835290332269 0.33517407175648 no 2197 0.323349460983328 3284 4230703
SGTC_1597 7-benzyloxygramine 47.5 µM -0.460798518796608 0.334349583554778 no 2198 0.322471582264247 3270 260807
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.461370855149708 0.334156747450185 no 2199 0.322266278889869 3389 94937 An inhibitor of serotonin biosynthesis.
SGTC_2219 9098279 200 µM -0.464242018757272 0.333190033619869 no 2200 0.32123717986776 3303 902349
SGTC_1686 st019653 115.5 µM -0.464587807192854 0.333073682070651 no 2201 0.321113332737153 3331 97252
SGTC_2902 5787006 60.46 µM -0.46531502593065 0.332829038565274 no 2202 0.320852937961015 3164 591003
SGTC_3102 9121669 49.47 µM -0.469433514907224 0.3314448836705 no 2203 0.319379898534972 3237 41905072
SGTC_1447 4239-0816 81.9 µM -0.469969227314108 0.331265008314001 no 2204 0.319188501644776 3247 1341554
SGTC_2612 dictamnine 15.46 µM -0.47015813160338 0.331201589482914 no 2205 0.319121022268462 3264 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2470 5664817 21.68 µM -0.470830718213788 0.330975828438562 no 2206 0.318880813156919 3311 2859561
SGTC_665 3914-0008 307 µM -0.471688211336792 0.330688090616656 no 2207 0.318574676418237 3214 1069549
SGTC_24 0417-1663 219 µM -0.473693439290176 0.330015613011624 no 2208 0.317859266239856 3316 4329390
SGTC_3083 9117465 49.47 µM -0.474377761746168 0.329786242658361 no 2209 0.317615274149105 3292 16420915
SGTC_248 streptozotocin 5.23457 mM -0.474688176928585 0.329682219174899 no 2210 0.317504623117042 3317 5300 DNA alkylating agent.
SGTC_864 0469-0573 172 µM -0.474769513894188 0.329654964456362 no 2211 0.317475632323286 3241 689425
SGTC_2729 fluphenazine 10.66 µM -0.475312942516496 0.329472893420171 no 2212 0.317281967734056 3214 3372 An atypical antipsychotic.
SGTC_1363 1636-0063 10.4 µM -0.476466765868259 0.329086448995532 no 2213 0.31687093937681 3267 6072185
SGTC_320 4092-0846 5.34 µM -0.477789591823351 0.328643626009084 no 2214 0.316399984934821 3293 1359356
SGTC_2282 7944268 200 µM -0.47818162220897 0.3285124379373 no 2215 0.31626047083185 3410 2970414
SGTC_2658 polymyxin b sulfate 77.05 µM -0.478254912687159 0.328487914538897 no 2216 0.316234391429794 3276 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2011 4012611 177 µM -0.478652706636536 0.328354823378321 no 2217 0.316092857907767 3214 2049887
SGTC_974 1326-0144 138 µM -0.480474057437458 0.327745726739137 no 2218 0.31544517285744 3261 5411856
SGTC_1136 pergolide 1.05886 µM -0.480842587754281 0.327622538391029 no 2219 0.315314189767553 3196 47811 A dopamine receptor agonist.
SGTC_834 0312-0008 75.7 µM -0.481890553097859 0.327272338381927 no 2220 0.314941848678843 3310 6385573 YIL048W NEO1
SGTC_882 0843-0131 351 µM -0.485401212268049 0.326100285407248 no 2221 0.313695886306573 3380 5425421
SGTC_35 0133-0054 64.071 µM -0.486291143884503 0.325803448957008 no 2222 0.313380378693605 3276 99677
SGTC_1441 4106-0040 13 µM -0.486342448157117 0.325786339794561 no 2223 0.313362193940724 3317 2904180
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.486673274304971 0.325676023325687 no 2224 0.313244943810484 3346 66535 A nucleotide analog.
SGTC_2903 5923464 63.88 µM -0.487566812070037 0.325378142747292 no 2225 0.312928353964985 3345 2876576
SGTC_2973 9094665 17.96 µM -0.488036056578302 0.325221754359669 no 2226 0.312762150901908 3406 25237061 YIL048W NEO1
SGTC_1677 st019204 53.9 µM -0.490124353878506 0.324526146565013 no 2227 0.312022952817414 3310 3945625
SGTC_2031 5180455 200 µM -0.490183177746545 0.32450656129566 no 2228 0.312002141773542 3283 29949
SGTC_3165 9101544 49.47 µM -0.492508316104569 0.323732801137121 no 2229 0.311180022242412 3352 5002184
SGTC_2463 5473429 200 µM -0.494366082234795 0.32311512012742 no 2230 0.310523831663812 3291 5399405
SGTC_2025 5147754 141 µM -0.496259236114239 0.322486174566419 no 2231 0.309855761318398 3300 315777 YLR208W SEC13
SGTC_2769 toremifene 3.73 µM -0.497452693451407 0.322089943696531 no 2232 0.309434927427921 3436 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.499378155327136 0.321451111705783 no 2233 0.308756502698456 3572 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2774 tamoxifen 10.92 µM -0.499443022753529 0.321429599094337 no 2234 0.308733658399408 3366 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2837 9008476 45.46 µM -0.500120635846819 0.321204911535772 no 2235 0.308495068308137 3398 2992805
SGTC_759 3486-0358 89.3 µM -0.501370210438907 0.320790740721765 no 2236 0.308055300501826 3426 875103
SGTC_644 1498-1197 63.3 µM -0.502231526615447 0.320505387713286 no 2237 0.307752334363369 3390 6741615
SGTC_2314 7727897 200 µM -0.503240591920115 0.320171220520212 no 2238 0.307397564466005 3262 900724
SGTC_2089 5281248 129.67 µM -0.503299105962406 0.320151847182906 no 2239 0.307376997463717 3332 2737878
SGTC_325 2810-4341 181 µM -0.503473202372554 0.320094208731235 no 2240 0.307315808191546 3386 774970
SGTC_1739 st037196 92.5 µM -0.504373323116736 0.319796273208458 no 2241 0.306999530363887 3411 612214
SGTC_193 1273-0060 1.558 µM -0.504757264930331 0.319669225712754 no 2242 0.306864667369293 3334 2847393 YHR072W ERG7
SGTC_768 0384-0033 77.3 µM -0.505003768504311 0.319587668093747 no 2243 0.306778094559715 3270 3965305 YMR134W ERG29
SGTC_2707 st078556 66.6 µM -0.506718679077743 0.319020518291339 no 2244 0.306176111201229 3320 17250899
SGTC_146 3448-8650 53.125 µM -0.507680710627752 0.318702543557134 no 2245 0.305838639074538 3287 2891488 YIL048W NEO1
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.508699475234708 0.318365962643751 no 2246 0.305481445145812 3376 616764
SGTC_424 splitomicin 100 mM -0.508964681853435 0.318278367875545 no 2247 0.305388490133453 3324 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1370 2001-0092 44.6 µM -0.509882928782443 0.317975159740931 no 2248 0.305066741218428 3472 790957
SGTC_1953 st076800 12.1 µM -0.510816948100961 0.317666868643647 no 2249 0.304739620251566 3303 297591
SGTC_2409 alverine citrate 63.97 µM -0.512688681767616 0.317049447389084 no 2250 0.304084554075899 3470 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2070 5230947 200 µM -0.514497161343259 0.316453374920335 no 2251 0.30345222226114 3429 2835538
SGTC_2624 nerol 100 µM -0.515199032502403 0.316222167373003 no 2252 0.303206972524781 3348 637566 A natural product oil.
SGTC_686 1319-0111 510 µM -0.516225275404266 0.315884235925222 no 2253 0.302848539555919 3447 4562600
SGTC_2321 7390090 138.78 µM -0.516709499297887 0.315724839268808 no 2254 0.30267948194186 3310 649046
SGTC_2210 7115885 190.385 µM -0.517946531465675 0.315317789089476 no 2255 0.302247787659032 3370 2927039
SGTC_3150 9097574 49.47 µM -0.519413165376132 0.314835477896074 no 2256 0.301736326214183 3406 17217476
SGTC_2610 ononetin 44.17 µM -0.519424306510048 0.314831815275651 no 2257 0.301732442439363 3359 259632
SGTC_2208 7283366 200 µM -0.522036063349391 0.313973709859197 no 2258 0.300822610692106 3409 898663
SGTC_1671 st016596 74.5 µM -0.522048941511788 0.313969481162492 no 2259 0.300818127522404 3422 2829167
SGTC_2780 5215298 71.43 µM -0.522193994738954 0.3139218529097 no 2260 0.300767633406568 3431 2834131
SGTC_2738 aclarubicin 5.55 µM -0.522730501119583 0.31374571788656 no 2261 0.300580904752951 3308 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1341 1486-1360 280 µM -0.523213744489219 0.313587105436805 no 2262 0.300412758872818 3291 3976547
SGTC_2502 avocadyne acetate 18.59 µM -0.524073944430664 0.313304851770955 no 2263 0.300113555099081 3318 3952079
SGTC_474 dl-dihydrosphingosine 5 µM -0.52490423719513 0.313032515096496 no 2264 0.299824881853697 3446 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_3331 9141060 1.957 µM -0.526301740885328 0.312574363112317 no 2265 0.299339286824901 3314 4906567 YPR165W RHO1
SGTC_1548 st061468 90.8 µM -0.530274645913625 0.311273485015009 no 2266 0.297960761452245 3382 390799
SGTC_3329 9141233 27.5565 µM -0.53281275811065 0.310443642707825 no 2267 0.297081600688557 3457 4909101 YNL103W MET4
SGTC_60 0986-0278 202 µM -0.532845410423566 0.310432973221452 no 2268 0.297070298190784 3276 3110598
SGTC_910 3454-3003 490 µM -0.535057670887435 0.309710465739693 no 2269 0.296304989474414 3435 820824
SGTC_1479 0549-0158 134 µM -0.53622546073674 0.309329370469606 no 2270 0.295901369528839 3400 5440202
SGTC_488 nitrendipine 139 µM -0.536940630688253 0.309096083874532 no 2271 0.295654312059731 3417 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_417 st075190 100 µM -0.539203755907546 0.308358365718045 no 2272 0.294873134518134 3468 222757
SGTC_3106 9121286 49.47 µM -0.539618318224398 0.308223313221428 no 2273 0.294730140523507 3488 15943471
SGTC_3026 9090633 49.47 µM -0.540130742496303 0.308056415982015 no 2274 0.294553435440939 3349 25236842
SGTC_3236 9132701 49.47 µM -0.540191344553492 0.308036680438293 no 2275 0.294532540578139 3396 24282524
SGTC_3303 9125618 40.5795 µM -0.540625045462454 0.307895458479257 no 2276 0.294383025671279 3384 22695467
SGTC_1540 guanosine 70.6 µM -0.542346971115169 0.307335044831601 no 2277 0.293789751676995 3401 6802 Guanosine is a purine nucleoside
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.542893311212375 0.30715732822248 no 2278 0.293601630781046 3428 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1666 st014829 29 µM -0.543052850853447 0.307105440803123 no 2279 0.293546707132782 3401 3858230
SGTC_3347 9188721 44.724 µM -0.544358681597409 0.306680887930869 no 2280 0.293097336441911 3417 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1029 k015-0030 64.7 µM -0.545078971175705 0.306446817627235 no 2281 0.292849602470395 3423 2208316
SGTC_484 loperamide 105 µM -0.545129039163096 0.306430550119958 no 2282 0.292832385869131 3374 3955 An opioid-receptor agonist.
SGTC_338 4055-0136 114 µM -0.545910745578708 0.306176616665306 no 2283 0.292563645776301 3372 2900563
SGTC_2048 5246248 200 µM -0.547305861184485 0.305723651656556 no 2284 0.292084308893971 3463 677046
SGTC_703 3875-0075 71.8 µM -0.548115231133916 0.305461002198661 no 2285 0.291806391442821 3427 2850814
SGTC_2010 4012422 159 µM -0.549712437440692 0.304942984924595 no 2286 0.291258312398714 3367 952393
SGTC_427 1354-0053 47.3 µM -0.549986363205679 0.304854182596036 no 2287 0.291164363460699 3517 6813657
SGTC_560 2332-1943 155 µM -0.551581659420398 0.304337241732118 no 2288 0.290617502496183 3434 21177716
SGTC_2913 7966556 36.57 µM -0.552893581015787 0.303912418469183 no 2289 0.290168141560505 3434 2976516
SGTC_1167 k781-0610 148 µM -0.552900442554796 0.303910197277625 no 2290 0.290165792194103 3400 4525169
SGTC_3086 9117350 49.47 µM -0.556174393238509 0.302851193347106 no 2291 0.289045821297913 3406 2679265
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.556231290254534 0.30283280384624 no 2292 0.289026375644632 3338 279621
SGTC_1214 0358-0031 63.7 µM -0.556431038228324 0.302768247907675 no 2293 0.288958112792609 3507 4301366
SGTC_546 peri-Naphthalide 147 µM -0.556882166212109 0.3026224719144 no 2294 0.288803970022498 3354 223824 A penicillin ester.
SGTC_3225 9130819 49.47 µM -0.558153438111406 0.302211846651805 no 2295 0.288369806369214 3477 4547121
SGTC_954 1189-0853 2.85 µM -0.558284503759912 0.302169526212423 no 2296 0.288325062448396 3449 2828194
SGTC_2793 7325131 81.82 µM -0.560286667310247 0.301523368657818 no 2297 0.287641960018471 3380 4176441
SGTC_677 0929-0063 136 µM -0.561715006369648 0.301062781601306 no 2298 0.287155104213763 3427 1539583
SGTC_629 3448-6466 76.7 µM -0.562858559501088 0.300694256311611 no 2299 0.286765600385991 3472 573744
SGTC_1242 0402-0103 60.1 µM -0.563358656503555 0.300533157375447 no 2300 0.286595341882305 3431 432868
SGTC_1015 4130-4525 82 µM -0.564176401563262 0.300269816772574 no 2301 0.286317043137174 3359 1363237
SGTC_368 fentichlor 4.58 µM -0.564938492280889 0.300024492625325 no 2302 0.286057800487231 3396 7329 A pesticide.
SGTC_1087 pterostilbene 9.05 µM -0.566399770036092 0.299554347445573 no 2303 0.285561025525589 3503 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1836 st055642 81 µM -0.567103732015421 0.299327976998287 no 2304 0.285321853748299 3375 8571
SGTC_2715 st079500 56.4 µM -0.569341840514251 0.298608792777715 no 2305 0.284562088785469 3422 28246688
SGTC_315 k915-0449 187 µM -0.569569913969079 0.298535548768477 no 2306 0.284484719550959 3456 20970215 YNL149C PGA2
SGTC_647 0140-0236 81 µM -0.570223461605614 0.298325712323333 no 2307 0.284263072609466 3458 990837
SGTC_1424 4048-1941 275 µM -0.570831722191841 0.298130476670887 no 2308 0.284056858710258 3514 X1424
SGTC_973 1325-0077 65.9 µM -0.571088358061457 0.298048120769221 no 2309 0.283969874900056 3456 2835149
SGTC_2262 9014885 67.46 µM -0.571890762971034 0.29779069140215 no 2310 0.283697991133784 3435 6457424
SGTC_2662 daunorubicin 22.37 µM -0.571972108998322 0.297764599447532 no 2311 0.283670435123235 3403 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2650 prasterone 100 µM -0.572350850566464 0.297643130815473 no 2312 0.283542153096046 3446 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2642 cholecalciferol 100 µM -0.572895534449399 0.297468481418698 no 2313 0.283357714168392 3454 9821465 A vitamin D precursor, similar to steriods.
SGTC_1153 4055-0057 267 µM -0.573398935489421 0.297307110724813 no 2314 0.283187305457743 3390 882706
SGTC_1912 st060209 90.8 µM -0.574153258769186 0.297065379073377 no 2315 0.282932047923123 3412 688787
SGTC_2821 7996764 71.43 µM -0.574422431683979 0.296979141252753 no 2316 0.282840988510523 3577 2987135
SGTC_678 1218-2179 85.9 µM -0.576276902339936 0.296385316046514 no 2317 0.282214016233163 3461 6820081 YOR116C RPO31
SGTC_1765 st044815 90.4 µM -0.57643576816346 0.296334470501834 no 2318 0.282160336897203 3436 645695
SGTC_1617 st002906 78 µM -0.576554127275672 0.296296591867262 no 2319 0.282120347610701 3507 5150859
SGTC_1031 k035-0009 16 µM -0.577248344872838 0.296074465142132 no 2320 0.281885851409718 3513 5180959
SGTC_1673 st016611 27.3 µM -0.577296156469935 0.296059169821965 no 2321 0.281869704832856 3507 5226799
SGTC_2196 6573537 42.6665 µM -0.577878907268492 0.295872772240071 no 2322 0.281672938395709 3536 2903087
SGTC_1300 1094-0077 113 µM -0.578189689414793 0.295773388084667 no 2323 0.281568029552666 3444 5532636
SGTC_1561 5-methoxyflavone 52.9 µM -0.579044646905795 0.295500062778504 no 2324 0.281279524014417 3460 94525
SGTC_2689 tacrolimus 100 µM -0.580378637790343 0.295073825250885 no 2325 0.280829653850408 3446 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1646 st011709 75.6 µM -0.580760159497181 0.294951973312612 no 2326 0.28070105488108 3485 5757843
SGTC_2113 5491891 107.031 µM -0.580895631185299 0.29490871139844 no 2327 0.280655398489087 3458 789979
SGTC_2110 5483698 200 µM -0.581299427219186 0.2947797793761 no 2328 0.280519333289861 3447 2848765 YHR062C RPP1
SGTC_1410 3909-8106 77.9 µM -0.58154170285214 0.294702433273962 no 2329 0.280437710167376 3500 1039210
SGTC_355 1311-2252 105 µM -0.582378437639351 0.29443537906126 no 2330 0.280155901080454 3421 5338538
SGTC_2946 9065502 71.43 µM -0.583385221097303 0.294114199877206 no 2331 0.279817002239626 3363 16489101
SGTC_173 1273-0061 2.693 µM -0.584812557424686 0.293659135654163 no 2332 0.279336879906176 3450 2847414 YPL266W DIM1
SGTC_2485 5633444 17.78 µM -0.586082885421712 0.293254403242516 no 2333 0.278909908384591 3462 5724239
SGTC_211 3455-0679 143.504 µM -0.586613701342301 0.293085359451881 no 2334 0.278731589293126 3516 748649
SGTC_1399 3562-5772 25 µM -0.587539990162736 0.292790481547687 no 2335 0.278420550413546 3466 23847490
SGTC_3075 9116269 49.47 µM -0.589180542327934 0.29226856095357 no 2336 0.277870084165807 3544 17015205 YNL244C SUI1
SGTC_3288 9119690 36.221 µM -0.589483048971031 0.292172369627605 no 2337 0.27776863998347 3448 17595618 YKL019W RAM2
SGTC_2999 9069765 71.4286 µM -0.591188673154535 0.291630289644713 no 2338 0.277197005606358 3445 2097066
SGTC_1105 epirubicin 18.1 µM -0.591402668412458 0.291562310976078 no 2339 0.277125326447355 3415 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.591655251286679 0.291482083905468 no 2340 0.277040733777383 3457 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1329 1447-1697 50.6 µM -0.592734664031742 0.291139349651144 no 2341 0.276679369539455 3495 2840515
SGTC_1004 4084-0029 199 µM -0.592932999867479 0.29107639469077 no 2342 0.276612996083056 3522 716894 YLR208W SEC13
SGTC_533 1222-0222 6.71 µM -0.593949114451821 0.290753963478966 no 2343 0.276273073907357 3555 3982874
SGTC_1529 apigenin 74 µM -0.594258196737509 0.290655919315858 no 2344 0.276169716864903 3578 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_428 3448-4153 16.5 µM -0.594686905678637 0.290519953922343 no 2345 0.276026388123248 3428 3834874
SGTC_270 tamoxifen 5.46 µM -0.5950932153725 0.290391119948338 no 2346 0.275890581765384 3606 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1108 betulinic acid 729.144 nM -0.595682412031269 0.290204343126084 no 2347 0.275693704966469 3479 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3233 9132340 49.47 µM -0.597616897235281 0.289591502542409 no 2348 0.275047793473363 3445 17682950
SGTC_820 1582-0060 59.9 µM -0.597970506960036 0.289479545489485 no 2349 0.274929806214743 3438 3848840
SGTC_2831 7999036 19.48 µM -0.599671263144783 0.288941350038921 no 2350 0.274362671760113 3546 2988270
SGTC_1079 idarubicin 2.36 µM -0.600006621349842 0.288835283276067 no 2351 0.274250911357785 3508 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3124 9127567 49.47 µM -0.600294926678251 0.288744113003878 no 2352 0.27415484962108 3514 17592030
SGTC_1489 4065-0444 182 µM -0.601348143944091 0.288411171232828 no 2353 0.273804064796606 3503 2877968
SGTC_455 paf C-16 10 µM -0.601465193120699 0.288374180964766 no 2354 0.273765094075031 3498 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2620 irigenin 100 µM -0.602206059469612 0.288140101827737 no 2355 0.273518491351534 3547 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1491 4138-0063 26.5 µM -0.603538979138241 0.287719187403509 no 2356 0.273075096432872 3508 23883227
SGTC_2066 5222451 176 µM -0.603745332878814 0.287654050216723 no 2357 0.273006484846174 3523 2281147
SGTC_763 3453-1109 128 µM -0.604187323171369 0.28751455594814 no 2358 0.272859554047558 3553 1560353
SGTC_1268 0828-0275 2.46 µM -0.605104024513013 0.287225342589839 no 2359 0.272554940176612 3537 745337
SGTC_4 0960-0234 25.671 µM -0.605486014549212 0.287104867854333 no 2360 0.272428057232995 3522 6821112
SGTC_2037 5169046 200 µM -0.605542300339626 0.287087118063994 no 2361 0.272409363657993 3518 5718022
SGTC_931 2812-0076 566 µM -0.605916825099056 0.286969024473673 no 2362 0.272284993131667 3508 3450959
SGTC_2030 5175110 200 µM -0.606664861219907 0.286733225737848 no 2363 0.272036673084853 3575 2831986
SGTC_1034 k072-0165 12.7 µM -0.608015685372696 0.286307646772689 no 2364 0.271588535415113 3553 5835461
SGTC_2870 9038528 12.99 µM -0.609949030254434 0.285699066150947 no 2365 0.270947785973421 3538 6463316
SGTC_331 k048-0133 24.5 µM -0.610605526369515 0.285492553575388 no 2366 0.270730381608261 3524 6813582
SGTC_2426 5582046 32.21 µM -0.611572505816489 0.285188502415369 no 2367 0.270410316707408 3559 2251934
SGTC_813 k007-0158 173 µM -0.612508569318161 0.284894319354314 no 2368 0.270100665058639 3527 6523916
SGTC_400 oxethazaine 37.5 µM -0.614607133422574 0.284235315869697 no 2369 0.269407101167585 3507 4621 A local anesthetic.
SGTC_1861 st057647 17.4 µM -0.615578413072748 0.283930555804767 no 2370 0.269086401101881 3588 688668
SGTC_375 3970-0961 9.27 µM -0.617547151041377 0.283313301726214 no 2371 0.268436945467805 3482 2898222
SGTC_1973 st070275 50.2 µM -0.617936244412835 0.28319138633845 no 2372 0.268308683037141 3509 17118334
SGTC_1101 ebselen 5.29 µM -0.618628809974115 0.282974445705365 no 2373 0.268080459010475 3601 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1096 rimcazole 32.2 µM -0.6193061960183 0.282762337146695 no 2374 0.267857331722155 3482 18528119 A dopamine reuptake inhibitor.
SGTC_1323 1348-1351 11.2 µM -0.620680981549392 0.282332088233608 no 2375 0.267404772598871 3482 6989654
SGTC_2093 5331342 194.4 µM -0.620997747033902 0.282232998886181 no 2376 0.267300552769769 3568 33839
SGTC_307 1501-1223 22.3 µM -0.624131834097415 0.28125350903705 no 2377 0.266270504483731 3546 2830329
SGTC_25 0118-0223 35.662 µM -0.624951880773517 0.280997492687671 no 2378 0.266001320138117 3590 5333628
SGTC_530 4358-1714 28 µM -0.625324976614406 0.280881050461995 no 2379 0.265878895239621 3551 1564641
SGTC_943 3253-1379 105 µM -0.626321453528752 0.28057016704525 no 2380 0.265552058733034 3563 668464
SGTC_2247 cerulenin 830 nM -0.626659536911374 0.280464728768743 no 2381 0.265441216390648 3622 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_82 0054-0107 293.755 µM -0.627028722885724 0.280349612420488 no 2382 0.265320203727485 3570 3104697
SGTC_829 1635-0120 117 µM -0.627423155382341 0.280226649208561 no 2383 0.265190946647684 3558 285054
SGTC_1806 st050005 60.3 µM -0.628222962165819 0.279977391945976 no 2384 0.2649289450159 3515 5194765
SGTC_2270 7924575 90.91 µM -0.62955147359761 0.279563603265279 no 2385 0.264494040620548 3556 1262135
SGTC_2737 bleomycin 30.5 nM -0.629571281318044 0.279557436043027 no 2386 0.264487559071805 3576 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_57 miconazole 162.5 nM -0.631232792913448 0.279040352270293 no 2387 0.263944161569843 3518 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_406 estrone 100 µM -0.632542771471266 0.278632998293 no 2388 0.263516134522982 3590 5870 A steroid.
SGTC_2107 5363541 170.161 µM -0.632868617717437 0.278531717379033 no 2389 0.263409721406049 3552 244052
SGTC_2260 7964312 200 µM -0.633373319267964 0.278374879308288 no 2390 0.263244942000131 3613 231951
SGTC_3232 9132874 49.47 µM -0.634452969655002 0.27803951812187 no 2391 0.262892625100937 3531 3784940
SGTC_2383 9036125 200 µM -0.634902486685741 0.27789994720846 no 2392 0.262746007580549 3521 79580
SGTC_1278 0874-0585 172 µM -0.639465377202639 0.276485150158814 no 2393 0.261260115116048 3558 766306
SGTC_669 0108-0021 26.2 µM -0.639641527172122 0.276430602930815 no 2394 0.261202839047279 3696 17201
SGTC_1722 st034304 3.6505 µM -0.639688499993471 0.276416058050741 no 2395 0.261187566682567 3565 4036148 YLR033W RSC58
SGTC_3006 9075424 71.4286 µM -0.639755537579157 0.276395300874998 no 2396 0.261165771416823 3541 7465181
SGTC_81 0411-0046 9.971 µM -0.641812894217709 0.275758643494163 no 2397 0.260497338254616 3492 12925265
SGTC_2894 9048625 32.47 µM -0.641821492918729 0.275755984104335 no 2398 0.260494546394842 3651 4092861
SGTC_2427 5545055 42.75 µM -0.643402728290099 0.275267157044127 no 2399 0.259981406788937 3591 5372858
SGTC_828 2074-0507 139 µM -0.644851443736996 0.274819672260929 no 2400 0.259511730313174 3633 X828
SGTC_2507 purpurin 79.67 µM -0.645296917168917 0.274682144838404 no 2401 0.259367395062781 3537 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_3333 9141820 12.094 µM -0.645538410813531 0.274607604640884 no 2402 0.259289167453795 3562 1939433
SGTC_2170 morpholine 200 µM -0.647297506755582 0.274064937725095 no 2403 0.258719707427362 3588 121171 Reacts with secondary amines.
SGTC_2266 7929956 200 µM -0.650491425623441 0.273080995945555 no 2404 0.257687419265552 3606 2967153
SGTC_2811 7967822 32.47 µM -0.652234300797703 0.272544812577908 no 2405 0.257125017752049 3592 2232244
SGTC_3231 9132313 49.47 µM -0.653019179410192 0.272303520963136 no 2406 0.256871956973027 3594 4905967
SGTC_1610 st001799 48.1 µM -0.653280594316126 0.272223178952234 no 2407 0.256787700289074 3535 621897
SGTC_1343 1487-0095 224 µM -0.653777384141489 0.272070530409372 no 2408 0.256627619528563 3597 4560101 YGL055W OLE1
SGTC_2638 epoxomicin 18 µM -0.653929629723607 0.27202375845124 no 2409 0.256578571786535 3579 9915668 A protesome inhibitor.
SGTC_2173 5763948 167 µM -0.655028596325375 0.27168625928952 no 2410 0.256224671375916 3604 2867177
SGTC_1817 st052116 64.4 µM -0.655770613528678 0.271458499351557 no 2411 0.255985863452624 3610 4361398
SGTC_2671 danthron 100 µM -0.657393542676742 0.270960677913115 no 2412 0.255463951289754 3570 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1219 1469-0211 33.1 µM -0.658557908417872 0.270603798228978 no 2413 0.255089849772688 3590 6822282
SGTC_283 0987-0079 11.7 µM -0.659059318325388 0.270450187762268 no 2414 0.254928839042229 3631 411556
SGTC_229 benomyl 22.8748 µM -0.659561842534926 0.270296279653615 no 2415 0.254767523867712 3614 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2049 5262831 67.185 µM -0.661802180291803 0.269610664539056 no 2416 0.254049004323433 3642 763417
SGTC_3010 9080089 71.4286 µM -0.661929258809258 0.269571800571261 no 2417 0.254008279676123 3619 17027233
SGTC_2366 9070441 60.58 µM -0.662028608941721 0.26954141863142 no 2418 0.253976443485442 3608 6837235
SGTC_2591 skatole 100 µM -0.662039650069241 0.269538042286187 no 2419 0.253972905547559 3622 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_972 1319-0219 195 µM -0.663315023161704 0.269148179516364 no 2420 0.253564408437858 3582 23903702
SGTC_102 gallobenzophenone 83.616 µM -0.664068550986079 0.268917970194993 no 2421 0.253323218679278 3661 70837
SGTC_3064 1327-0027 10 µM -0.664671715232837 0.268733769523744 no 2422 0.253130244351423 3515 16000455 YPR107C YTH1
SGTC_1803 st050068 52.4 µM -0.666174456643184 0.268275122322896 no 2423 0.252649798851325 3702 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1230 0170-0365 3.77 µM -0.666807379725549 0.268082067690357 no 2424 0.252447589149369 3698 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_712 r015-0009 80.6 µM -0.666825315602011 0.26807659789612 no 2425 0.252441860141181 3593 6813872 YLR060W FRS1
SGTC_1284 0929-0043 16 µM -0.667267914816361 0.267941638928618 no 2426 0.252300508524519 3595 1239883
SGTC_1621 st003705 32.4 µM -0.667597434104682 0.267841182928857 no 2427 0.252195298017997 3653 24207032
SGTC_1805 st050013 60.3 µM -0.668502010941564 0.267565514628215 no 2428 0.251906599347123 3587 4037144
SGTC_1733 st037357 54.9 µM -0.669389054678114 0.267295328492099 no 2429 0.251623665907234 3594 1272339 YGL099W LSG1
SGTC_713 1488-1073 324 µM -0.670193612944647 0.267050385857935 no 2430 0.251367187462212 3606 3312542
SGTC_1005 4092-0690 4.4 µM -0.671893554292007 0.266533222557536 no 2431 0.250825732071037 3618 1529343
SGTC_1170 0310-0127 64.8 µM -0.672820939827231 0.266251303123137 no 2432 0.250530607161751 3612 774975
SGTC_2557 derrustone 83.84 µM -0.673554926780278 0.26602828270985 no 2433 0.250297158611553 3631 629853 An antioxidant.
SGTC_2027 5150920 200 µM -0.674490759476595 0.265744069182654 no 2434 0.249999679274407 3622 786715
SGTC_2911 7942208 15.64 µM -0.67526259100358 0.265509778897077 no 2435 0.249754473320206 3617 1243384
SGTC_3217 9129673 49.47 µM -0.675445814151682 0.265454176708979 no 2436 0.249696283256406 3634 17248312
SGTC_825 1988-2224 89.6 µM -0.675792096197969 0.265349107655319 no 2437 0.249586326783848 3638 1180859
SGTC_1716 st033144 30.6155 µM -0.676172426522657 0.265233731985834 no 2438 0.249465588458267 3654 674617
SGTC_2006 4011487 200 µM -0.67632533840305 0.265187352355652 no 2439 0.249417054340921 3665 45595294
SGTC_383 2324-0395 7.37 µM -0.676606462918013 0.26510209535889 no 2440 0.249327838724829 3643 3146421
SGTC_810 3825-7150 143 µM -0.67681213425337 0.265039729965864 no 2441 0.249262579124706 3670 22330411 YGL099W LSG1
SGTC_1703 st026983 48.3 µM -0.677459769131816 0.264843397368078 no 2442 0.249057143651186 3651 1104023
SGTC_1007 4101-0031 70 µM -0.677684742672358 0.264775213220645 no 2443 0.248985801154068 3616 1146276
SGTC_1021 4476-0760 85.3 µM -0.677964835362097 0.264690336240338 no 2444 0.248896994744617 3629 746768
SGTC_1783 st039459 87.517 µM -0.678767974843689 0.264447036217988 no 2445 0.248642444214738 3690 729761
SGTC_2311 7694451 200 µM -0.678880082093808 0.264413083928399 no 2446 0.248606923485824 3600 2163142
SGTC_418 lividomycin a 100 µM -0.679354830598903 0.264269328361792 no 2447 0.248456531307726 3654 72394 An antibiotic.
SGTC_1129 3453-1384 223 µM -0.67965565446188 0.264178258409647 no 2448 0.24836126057106 3707 1084452
SGTC_3148 9097893 49.47 µM -0.679882973935091 0.264109451423746 no 2449 0.248289281549855 3585 17174100
SGTC_751 0833-0568 350 µM -0.680060086708922 0.264055847756014 no 2450 0.248233207816315 3680 6954252
SGTC_189 3970-0742 2.116 µM -0.68063612800204 0.263881545617792 no 2451 0.248050880405147 3658 2891807
SGTC_1942 st076330 65.2 µM -0.681077400913206 0.263748062217896 no 2452 0.247911257950707 3683 24208414
SGTC_2116 5511452 16.8835 µM -0.681465541027647 0.263630679762473 no 2453 0.247788481841178 3647 870744
SGTC_2997 9067075 71.4286 µM -0.682231673380573 0.263399062051987 no 2454 0.247546234898189 3651 27209819
SGTC_1631 benzylvanillin 81.9 µM -0.683006694473885 0.263164862840427 no 2455 0.247301306179409 3656 75506
SGTC_939 1165-0479 45.3 µM -0.684339434099428 0.262762378755476 no 2456 0.246880425669317 3604 1377347
SGTC_1058 3448-5425 97.3 µM -0.684525064259252 0.262706343896241 no 2457 0.246821833912363 3589 7279705
SGTC_1725 st036284 20.55 µM -0.685319566863494 0.262466582127112 no 2458 0.246571143583606 3676 707914
SGTC_1446 4239-0190 62 µM -0.685673217796628 0.262359894826684 no 2459 0.246459599578893 3669 1340085
SGTC_3021 9087658 49.47 µM -0.68568727355419 0.262355655028643 no 2460 0.246455166852338 3626 25237042
SGTC_1712 st032288 53.4 µM -0.687183813846661 0.261904437396105 no 2461 0.245983451474322 3646 2883011
SGTC_1138 3761-0006 1.03 µM -0.687499812409253 0.261809212474042 no 2462 0.245883909466386 3630 12061087
SGTC_2629 bisabolol 100 µM -0.688183550847672 0.261603231392371 no 2463 0.245668600551234 3654 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2920 7982904 15.77 µM -0.688475883514821 0.261515189481709 no 2464 0.245576576037978 3638 6456808
SGTC_379 3970-0972 5.9 µM -0.688568478194736 0.261487305888774 no 2465 0.245547431667911 3664 2898042 YBL034C STU1
SGTC_2584 androsterone 48.74 µM -0.690874916653503 0.260793247100654 no 2466 0.244822075237914 3714 2754130 A steroid.
SGTC_2543 pimpinellin 60.67 µM -0.692203597545347 0.260393848082411 no 2467 0.244404739896464 3593 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2295 7971645 200 µM -0.692662635966718 0.260255935246399 no 2468 0.244260646227808 3665 2978226 YKL099C UTP11
SGTC_2929 9013348 24.6 µM -0.693743482454403 0.259931356011521 no 2469 0.243921545905751 3684 2995952
SGTC_1276 0871-0068 94.2 µM -0.696087098102766 0.259228283863031 no 2470 0.243187142936177 3651 3414906
SGTC_1959 st077091 55.8 µM -0.698610401811129 0.258472406568169 no 2471 0.24239777068702 3690 821356 YKL052C ASK1
SGTC_134 0269-0018 6.916 µM -0.698676349427018 0.25845266671354 no 2472 0.242377158738935 3604 4378915
SGTC_275 trichlorophene 5.69 µM -0.699462739207138 0.258217339777301 no 2473 0.242131445560912 3715 62616
SGTC_1077 5-fluorocytosine 377 nM -0.700426872179023 0.257928974877433 no 2474 0.241830379622795 3673 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3177 9107506 49.47 µM -0.70065798979928 0.257859874173932 no 2475 0.241758239644371 3619 8897194
SGTC_1151 3909-8316 15.3 µM -0.701693045217769 0.25755052600917 no 2476 0.241435305588941 3697 800431
SGTC_786 4544-0069 423 µM -0.702473168866299 0.257317497035539 no 2477 0.241192064389773 3708 748821 YLR208W SEC13
SGTC_168 3970-0862 530.542 µM -0.702693422298064 0.257251725472103 no 2478 0.241123413872434 3687 3135186
SGTC_1828 st055811 49 µM -0.705515326759138 0.25640982885357 no 2479 0.240244798620129 3647 5877589
SGTC_1053 3366-3204 134 µM -0.705702838756124 0.256353936797881 no 2480 0.240186477621868 3682 3632071 YPR165W RHO1
SGTC_3129 9127257 49.47 µM -0.708556536856458 0.255504113880233 no 2481 0.23929985794946 3644 837894
SGTC_1364 1653-0028 37.6 µM -0.708628699793008 0.255482643065606 no 2482 0.239277460741931 3681 5718652
SGTC_2496 diffractaic acid 79.83 µM -0.708784868058171 0.255436181168227 no 2483 0.239228994725399 3732 94870 An apoptosis inducer which activates caspases.
SGTC_2649 anisomycin 9.56 µM -0.709154681725674 0.255326174858386 no 2484 0.239114246352357 3671 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2108 5365811 200 µM -0.709209894709041 0.255309753099829 no 2485 0.239097117062775 3740 780283
SGTC_334 1502-1024 68.5 µM -0.709945714822287 0.255090954029191 no 2486 0.238868900092014 3721 3296216
SGTC_1106 tegaserod maleate 11.7 µM -0.710062027731024 0.255056376897218 no 2487 0.238832836177537 3729 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_866 0495-0101 262 µM -0.712221801283332 0.254414771987111 no 2488 0.238163719388308 3679 635694
SGTC_2346 9031566 143.75 µM -0.713155248394056 0.254137734443541 no 2489 0.237874847502932 3678 4771086
SGTC_3346 9158254 43.5805 µM -0.713530438047553 0.254026426591824 no 2490 0.237758792516622 3684 17639500
SGTC_3071 9117417 49.47 µM -0.713872155792591 0.253925071141936 no 2491 0.237653118210191 3626 45595590 YGL055W OLE1
SGTC_2752 diclazuril 33.15 µM -0.71591553553234 0.253319436126599 no 2492 0.237021752524924 3745 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1293 1000-1278 195 µM -0.716706033858784 0.253085345093863 no 2493 0.236777751012546 3744 678847
SGTC_2290 7904846 200 µM -0.717065104138419 0.252979050862363 no 2494 0.236666963159474 3756 2962154
SGTC_2741 miltefosine 3.04 µM -0.717110668047465 0.252965564428639 no 2495 0.236652906870865 3637 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_735 3076-0345 636 µM -0.717980708160617 0.252708114389469 no 2496 0.23638459101267 3733 2888990
SGTC_335 4077-0256 27.6 µM -0.71883209862415 0.252456316531752 no 2497 0.236122188817081 3725 3121989
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.718889186556519 0.252439437565443 no 2498 0.236104599813552 3718 23847180
SGTC_1928 4'-methoxychalcone 40.3 µM -0.718992763158045 0.252408814994121 no 2499 0.23607268932169 3721 641818
SGTC_3190 9110366 49.47 µM -0.719321670820272 0.252311585951935 no 2500 0.235971373259155 3642 17123768
SGTC_1910 st062352 60.4 µM -0.720471697355522 0.251971779621574 no 2501 0.235617309815094 3655 2245730
SGTC_1411 3909-8223 150 µM -0.720492153789156 0.251965737403862 no 2502 0.235611014461727 3705 X1411
SGTC_2930 9013230 14.89 µM -0.720531884160479 0.251954002460784 no 2503 0.235598787926628 3696 2995857
SGTC_1502 4534-4282 27.7 µM -0.721942595420731 0.251537515378717 no 2504 0.235164885734449 3690 3278949
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.724776033971566 0.2507020939709 no 2505 0.234294720388031 3658 1241132 A phosphatase inhibitor.
SGTC_259 usnic acid 108.925 µM -0.72479009285518 0.250697952464848 no 2506 0.234290407271638 3788 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3153 9100258 49.47 µM -0.726340487712637 0.250241455131467 no 2507 0.233815032327683 3677 25236848
SGTC_1793 st048256 72.231 µM -0.727090629541492 0.250020742152848 no 2508 0.233585219313158 3627 672022
SGTC_2344 7990960 76.95 µM -0.727704597850949 0.249840172178482 no 2509 0.233397217589958 3715 140813
SGTC_3095 9117207 49.47 µM -0.728269757628295 0.249674018158507 no 2510 0.233224235635772 3697 17015229
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.728373646675148 0.249643481708718 no 2511 0.233192445416 3691 61125 An anti-inflammatory.
SGTC_2526 patulin 37.61 µM -0.729041802438469 0.249447135900067 no 2512 0.232988046141454 3767 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2419 paclitaxel 166.5 µM -0.730824766494178 0.248923591893834 no 2513 0.232443096950211 3670 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2539 epi(13)torulosol 80 µM -0.73118605945453 0.248817574259991 no 2514 0.23233275698847 3727 6708597
SGTC_2876 9059903 25.97 µM -0.732518377255792 0.248426827421644 no 2515 0.23192611506232 3690 6916095
SGTC_184 1494-0393 24.714 µM -0.733993172102003 0.247994676079298 no 2516 0.23147644973854 3720 3090647
SGTC_2204 7233102 200 µM -0.734025242049488 0.247985283250247 no 2517 0.231466677006281 3661 2172480
SGTC_2329 6138490 200 µM -0.734078885417902 0.247969572299028 no 2518 0.231450330681244 3792 720019
SGTC_456 gingerol 170 µM -0.734090094267042 0.247966289543147 no 2519 0.231446915177416 3770 442793 A herb.
SGTC_681 1642-0006 26.6 µM -0.736447377748541 0.247276423264412 no 2520 0.230729240427959 3742 4446530
SGTC_3292 9120825 59.784 µM -0.737214685541017 0.24705208984411 no 2521 0.230495902092033 3741 24824900
SGTC_1206 3978-0017 132 µM -0.737995532171152 0.246823909975658 no 2522 0.230258582063601 3785 3873677
SGTC_591 4299-0174 154 µM -0.738821727894338 0.246582601034813 no 2523 0.230007628102633 3722 5509088
SGTC_1862 st057513 3.81 µM -0.739521705590178 0.246378255823305 no 2524 0.229795132240562 3725 5393163
SGTC_842 0271-0008 11.1 µM -0.740398575221825 0.246122398486964 no 2525 0.22952909154809 3794 1221709
SGTC_2396 5342950 42.78 µM -0.744102394944897 0.245043253792744 no 2526 0.228407265269124 3759 1886677
SGTC_44 0929-0055 61.211 µM -0.747127238675081 0.244163827181701 no 2527 0.227493379778643 3712 1379590
SGTC_1253 0550-0034 176 µM -0.748188848158043 0.243855584555163 no 2528 0.227173128290741 3738 5969915
SGTC_246 cycloheximide 667 µM -0.748353029744694 0.243807932521861 no 2529 0.227123622986598 3640 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_994 3910-0338 138 µM -0.748565608489204 0.24374624117369 no 2530 0.227059533632213 3839 3479481
SGTC_339 3091-4833 71.4 µM -0.74887564197672 0.243656283111169 no 2531 0.226966081393152 3682 3240077
SGTC_1289 0976-0073 69.1 µM -0.749677644246671 0.243423660567074 no 2532 0.226724437494492 3790 3391136
SGTC_2569 tetrandrine 100 µM -0.749824454563494 0.243381090904703 no 2533 0.226680219158692 3779 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_317 4495-0002 170 µM -0.75039719045609 0.243215056752456 no 2534 0.22650776127954 3784 15991618
SGTC_3091 9116372 49.47 µM -0.750529456887719 0.243176721877088 no 2535 0.226467944748607 3801 17169793
SGTC_2518 prenyletin 46.28 µM -0.751553111781669 0.242880145747798 no 2536 0.226159924761663 3706 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2598 perillyl alcohol 100 µM -0.75170713465178 0.242835538760944 no 2537 0.226113599443329 3773 10819 An apoptosis inducer.
SGTC_2829 7992743 58.44 µM -0.752227003515114 0.242685010851204 no 2538 0.22595727856309 3811 16462845
SGTC_2201 6605497 169.863 µM -0.753023901657147 0.242454367276608 no 2539 0.225717775600112 3737 670741
SGTC_123 0083-0120 66.675 µM -0.753430155875134 0.242336832184768 no 2540 0.225595733617938 3749 16001701
SGTC_2958 9077254 16.72 µM -0.754964525902602 0.241893195884135 no 2541 0.225135133713359 3766 16457351
SGTC_817 1391-0715 46 µM -0.755520622059413 0.241732519240824 no 2542 0.224968331791519 3762 1353946
SGTC_1269 0831-0796 3.05 µM -0.756045096879252 0.241581032262192 no 2543 0.224811078942167 3757 927758
SGTC_2133 5320837 200 µM -0.75648973176095 0.241452646281402 no 2544 0.224677813263842 3745 2841355
SGTC_2008 4012253 172 µM -0.758922532567056 0.240750844428153 no 2545 0.223949449544346 3788 603940
SGTC_2432 5630864 12.22 µM -0.761232230053733 0.240085583348467 no 2546 0.22325918536224 3767 5714970
SGTC_2137 5261020 140 µM -0.762145345870425 0.239822855705114 no 2547 0.222986630677258 3743 763655
SGTC_3337 9144342 33.5465 µM -0.76273428102537 0.23965348667647 no 2548 0.222810940812202 3781 17682949
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.767174490508097 0.238378652115969 no 2549 0.221488888810899 3808 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1970 st070122 35.8 µM -0.769554721840014 0.237696792673948 no 2550 0.220782036148188 3782 102928
SGTC_2955 9076254 12.21 µM -0.770605690399433 0.237396064981224 no 2551 0.220470343642964 3739 16459619
SGTC_2841 9004761 38.96 µM -0.771712341450281 0.23707963003579 no 2552 0.220142409765601 3779 2991039
SGTC_1650 st011916 45.8 µM -0.775838671339648 0.235901796254545 no 2553 0.21892212373788 3746 242528
SGTC_2134 5324836 1.464 µM -0.776470699224156 0.235721673325246 no 2554 0.218735557390347 3777 699272
SGTC_1741 st038134 10.228 µM -0.777626704727226 0.235392417247132 no 2555 0.218394556560184 3840 1272587
SGTC_2484 5809818 12.04 µM -0.777846939137196 0.235329718387515 no 2556 0.218329626112402 3801 2870548
SGTC_2373 9071805 200 µM -0.778527901492156 0.235135912541934 no 2557 0.218128932254056 3772 10149009
SGTC_3249 9135183 49.47 µM -0.779162018669043 0.234955518399162 no 2558 0.217942140294234 3796 4902779
SGTC_1385 3091-4834 14.1 µM -0.779566076755836 0.234840611544054 no 2559 0.217823164989122 3773 4072814
SGTC_913 3487-1245 167 µM -0.783335395116105 0.233770182922646 no 2560 0.216715091636587 3763 4016153
SGTC_2021 4019055 173 µM -0.783671492176314 0.233674868004919 no 2561 0.216616447121638 3778 44827708 YER133W GLC7
SGTC_279 1273-0055 2.93 µM -0.783703612008174 0.233665760159705 no 2562 0.216607021308243 3823 2847562
SGTC_2809 7964133 12.99 µM -0.784149540132966 0.233539333870036 no 2563 0.216476184761529 3837 1253665
SGTC_201 4262-0159 12.803 µM -0.785306130520617 0.233211602663474 no 2564 0.216137051140368 3820 1341029
SGTC_999 SEC7.066 22.7 µM -0.785840236672702 0.233060344663595 no 2565 0.215980545280155 3804 740511 YDR170C SEC7
SGTC_2289 7946404 165.07 µM -0.787356311850679 0.232631291537046 no 2566 0.215536656887734 3834 1246120 YPR165W RHO1
SGTC_103 0844-0104 51.839 µM -0.787684091277298 0.232538586887483 no 2567 0.215440756662213 3805 5375804
SGTC_2371 9071574 200 µM -0.791038005202764 0.231591193071264 no 2568 0.214460907016938 3787 45596039
SGTC_2103 5378138 10 µM -0.793948308955753 0.230770853994766 no 2569 0.213612762221369 3858 244142
SGTC_839 0122-0028 230 µM -0.796547654828414 0.230039540101725 no 2570 0.212856894195579 3830 759448
SGTC_1948 st076329 66.6 µM -0.798417697339203 0.229514215448161 no 2571 0.212314068347318 3712 24208413
SGTC_421 streptovitacin 30 mM -0.798651709432946 0.229448525087894 no 2572 0.212246197579318 3927 91467 include heat shock
SGTC_2882 9058044 58.44 µM -0.798978308339999 0.229356861974234 no 2573 0.21215149496652 3803 18076804
SGTC_1730 st033808 45.1 µM -0.799541094491248 0.229198958818618 no 2574 0.211988364034069 3802 1045166
SGTC_1444 4112-3581 28 µM -0.799733557755027 0.229144972625135 no 2575 0.211932592876987 3858 2877249
SGTC_2200 6600604 21.907 µM -0.800806551889797 0.228844127138012 no 2576 0.211621822703918 3794 2904777
SGTC_979 1426-2828 121 µM -0.80202119273625 0.228503834516835 no 2577 0.21127034964584 3959 747872
SGTC_192 3455-0609 60.9 µM -0.802156914970415 0.228465828369425 no 2578 0.211231097801106 3907 3769639
SGTC_3133 9127736 49.47 µM -0.803858032929439 0.227989767517452 no 2579 0.210739484782614 3800 27243420
SGTC_1552 6-methylflavone 10.6 µM -0.804214097912511 0.227890192773026 no 2580 0.21063666911824 3778 689013
SGTC_1565 sinapyl alcohol 95.1 µM -0.805185001950465 0.227618800627216 no 2581 0.210356464979217 3866 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1579 chlormadinone acetate 49.4 µM -0.805483379244602 0.227535433223034 no 2582 0.210270396895031 3871 45114258 A steroidal progestin.
SGTC_2244 6635614 200 µM -0.805751238196534 0.227460607373435 no 2583 0.210193149562495 3758 836499
SGTC_985 1493-0307 8.71 µM -0.805917441798913 0.227414185706349 no 2584 0.210145226803279 3842 3278274
SGTC_2127 5253358 187.912 µM -0.806003346622119 0.227390194064123 no 2585 0.210120459722966 3783 20612
SGTC_1895 st058434 18.3 µM -0.806335002052066 0.227297582162915 no 2586 0.210024856774171 3844 5393175
SGTC_1326 1431-2094 10.8 µM -0.807111304219942 0.227080889637505 no 2587 0.209801179970074 3819 616278
SGTC_3033 9090887 49.47 µM -0.807315953523577 0.227023784411917 no 2588 0.209742237472864 3881 19325384
SGTC_717 1532-0246 73.2 µM -0.80774709365075 0.226903505818408 no 2589 0.209618093614454 3850 9561992
SGTC_3260 9137109 49.47 µM -0.808452069852712 0.226706910453044 no 2590 0.209415193656672 3725 17478346
SGTC_1638 st008370 60.6 µM -0.80904829784465 0.226540716545008 no 2591 0.209243682869694 3822 24207134
SGTC_688 0527-0193 473 µM -0.809873577153928 0.226310789899168 no 2592 0.20900641972554 3862 4007154
SGTC_896 0964-0007 44.5 µM -0.810458755816902 0.226147836312997 no 2593 0.208838280213999 3804 6756758
SGTC_1840 st055363 71 µM -0.810981908935817 0.226002211015116 no 2594 0.208688030010798 3880 676033
SGTC_2618 avocadyne 43.43 µM -0.812057978014373 0.225702842335335 no 2595 0.208379182062509 3782 3015189
SGTC_2379 9035213 200 µM -0.812165590748591 0.225672916191017 no 2596 0.208348310431251 3824 646551
SGTC_1891 st059073 26.2 µM -0.813038974113471 0.225430119107988 no 2597 0.208097856545247 3893 688754
SGTC_2703 st077852 53.4 µM -0.815165366027297 0.224839609396649 no 2598 0.207488829840564 3872 6281836
SGTC_3293 9120939 62.045 µM -0.81586576921483 0.224645296090857 no 2599 0.207288456006758 3832 934087
SGTC_2795 7780010 54.55 µM -0.816018406596716 0.224602962448912 no 2600 0.207244804151851 3868 953673
SGTC_2443 5493264 126.67 µM -0.816643189305604 0.224429727522032 no 2601 0.207066182945308 3887 5340055
SGTC_278 4092-0821 23.9 µM -0.818100564400938 0.224025932687509 no 2602 0.206649883316916 3876 877900
SGTC_1051 3253-3903 78 µM -0.818145830964552 0.224013397295681 no 2603 0.206636960851093 3844 5509239
SGTC_3049 9092223 49.47 µM -0.819164977444311 0.223731276813645 no 2604 0.206346146850807 3844 8623917
SGTC_2536 dehydroabietamide 32.04 µM -0.824425585060522 0.222278249930069 no 2605 0.204848891169324 3918 3983547
SGTC_1380 2291-0730 164 µM -0.825332802093194 0.222028213922079 no 2606 0.204591336933721 3912 2999191
SGTC_2176 5809774 33.9695 µM -0.826858847208432 0.221607986559848 no 2607 0.204158535493153 3862 2870539
SGTC_780 0109-0199 192 µM -0.827452956377163 0.221444509600264 no 2608 0.203990187856463 3941 610414
SGTC_3327 9140648 26.9345 µM -0.828962237923668 0.221029521114423 no 2609 0.203562887770186 3889 8029710
SGTC_2363 9053361 176 µM -0.829154144124567 0.220976786951587 no 2610 0.203508594545698 3929 6469797 YMR079W SEC14
SGTC_995 3931-2021 34.6 µM -0.829213828438714 0.220960387686944 no 2611 0.203491710693626 3875 730143
SGTC_1334 1486-0610 236 µM -0.829447912712142 0.220896075837856 no 2612 0.203425499614124 3944 3742339
SGTC_2514 salinomycin 42.74 µM -0.833991329617314 0.219649950735853 no 2613 0.202142934858097 3964 23682228 A polyether potassium ionophore.
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.834297276688032 0.219566183803302 no 2614 0.2020567430429 3902 551469
SGTC_218 alverine citrate 93.75 µM -0.835560131139132 0.219220614167091 no 2615 0.201701202832791 3917 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1033 k072-0102 21.3 µM -0.835996504653449 0.21910127689802 no 2616 0.201578434718438 3840 5965931
SGTC_1207 2099-0101 141 µM -0.8364220030986 0.21898494966673 no 2617 0.201458769284283 3914 5837381
SGTC_111 0083-0039 52.457 µM -0.837642577894074 0.218651453290964 no 2618 0.201115736133795 3777 759313
SGTC_1619 st003326 88.7 µM -0.83791085589694 0.218578191183268 no 2619 0.201040385651995 3849 2849032
SGTC_2167 5876490 200 µM -0.839068331061669 0.218262266697149 no 2620 0.200715483072886 4046 686534
SGTC_1717 st033143 58.0435 µM -0.840898888422231 0.217763166737584 no 2621 0.20020229060214 3886 674616
SGTC_1482 3346-2049 8.48 µM -0.84103849227415 0.217725130900505 no 2622 0.200163185377523 3896 3826804
SGTC_2996 9066192 71.4286 µM -0.841792905981791 0.217519653069321 no 2623 0.199951941734854 3963 6472854
SGTC_3219 9131112 49.47 µM -0.843679023847083 0.217006425740322 no 2624 0.199424396071791 3846 17612988 YMR079W SEC14
SGTC_413 propylparaben 100 µM -0.843964274212197 0.216928867867851 no 2625 0.199344684780605 3855 7175 A pharmaceutical preservative.
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.84457709486313 0.216762299786088 no 2626 0.199173501074411 3968 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_3182 9108849 49.47 µM -0.845222771295292 0.216586881358154 no 2627 0.198993235349346 3938 17133045
SGTC_3041 9091929 49.47 µM -0.845405048939075 0.216537374738679 no 2628 0.198942363246123 3893 25236887
SGTC_1130 3454-2858 15.9 µM -0.847016955338984 0.216099865893769 no 2629 0.198492835417219 3949 715628 YIL048W NEO1
SGTC_1283 0922-0125 16.4 µM -0.847383064207114 0.216000566837165 no 2630 0.198390820578533 3909 3360884
SGTC_2639 lactacystin 53 µM -0.849639453976418 0.215389154021176 no 2631 0.197762784825289 3928 3870 A proteasome inhibitor.
SGTC_2983 9022671 12.99 µM -0.849774621733218 0.215352559584912 no 2632 0.197725200875519 3939 6405161
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.849973131435953 0.215298822903408 no 2633 0.197670012262699 3893 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_117 lucigenin 22.078 µM -0.85155070320564 0.214872050104209 no 2634 0.197231755214009 3944 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2126 5251174 33.877 µM -0.853273144117301 0.214406648207001 no 2635 0.196753924704176 3919 790722
SGTC_1573 oleylamine 1.06 µM -0.856439944000747 0.21355251323781 no 2636 0.195877239172468 3912 5356789 An amine of the fatty acid oleic acid.
SGTC_150 3970-0969 77.2 µM -0.858546378499819 0.212985474939377 no 2637 0.195295416250688 4003 6615640
SGTC_2988 9073640 71.4286 µM -0.859001593523451 0.212863049595257 no 2638 0.195169818421326 3971 9102229
SGTC_1467 k284-1082 293 µM -0.859392066829405 0.212758068595911 no 2639 0.195062122525395 3860 3334705
SGTC_1641 st009299 47.1 µM -0.859969007514892 0.212603010104278 no 2640 0.194903063460067 3838 4046054
SGTC_3032 9089427 49.47 µM -0.860073563629454 0.212574916684412 no 2641 0.19487424641457 3927 17173707
SGTC_1587 estradiol valerate 56.1 µM -0.860860506901071 0.2123635406917 no 2642 0.194657437613362 3965 13791 A steroid.
SGTC_1647 st011722 22.4 µM -0.861055948743863 0.212311063305986 no 2643 0.194603614672455 3881 2854783
SGTC_1525 8-methoxypsoralen 92.5 µM -0.861580762648249 0.212170184918059 no 2644 0.19445913041729 3961 4114 Related to psoralen; DNA damaging agent.
SGTC_2812 7970281 58.44 µM -0.861615865296521 0.212160764091137 no 2645 0.194449468788783 3971 2233435
SGTC_2776 terbinafine 19.92 µM -0.862070180080992 0.212038857438269 no 2646 0.194324449869221 3943 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_441 propafenone 146 µM -0.863472270091079 0.211662891875471 no 2647 0.193938929658402 3912 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1505 k297-0037 20.6 µM -0.864503638097866 0.211386583373047 no 2648 0.193655641324954 3935 4089396
SGTC_1319 1306-0155 43.7 µM -0.865197088950611 0.211200923350793 no 2649 0.193465311449199 3954 3122360
SGTC_704 1310-0270 142 µM -0.868076633805945 0.210430995567558 no 2650 0.192676190833841 3931 5718033
SGTC_1433 4060-0023 7.6 µM -0.870806110524676 0.209702716048189 no 2651 0.191930014135727 3933 3840627
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.871406051459362 0.209542838599936 no 2652 0.191766241390144 3994 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_287 k060-0039 29.6 µM -0.871514531944206 0.209513937438642 no 2653 0.191736637367854 3969 5861974
SGTC_789 1309-1135 70.6 µM -0.87287362784644 0.209152048502633 no 2654 0.191365981085034 3918 3092424
SGTC_3195 9113082 49.47 µM -0.873072691476568 0.209099074385162 no 2655 0.191311728810379 3843 17018038
SGTC_326 k292-0812 17.5 µM -0.873746329215673 0.208919866880372 no 2656 0.191128207303693 3904 3579357
SGTC_3068 9116768 49.47 µM -0.874730915995611 0.208658100587249 no 2657 0.190860167118761 3899 41904888
SGTC_403 arphamenine a 50 µM -0.874748670835807 0.208653381987604 no 2658 0.190855335726014 3909 5487158 An arginine aminopeptidase inhibitor.
SGTC_1859 st055998 20 µM -0.875086802067785 0.208563530841084 no 2659 0.190763338812906 3880 676301
SGTC_3131 9127911 49.47 µM -0.876364146797976 0.208224309706028 no 2660 0.190416051415958 3980 45595681
SGTC_2032 5185112 25.99 µM -0.876432804263884 0.208206085744452 no 2661 0.190397395669825 3832 5718189
SGTC_5 0352-0601 109.883 µM -0.877630989374896 0.207888199355279 no 2662 0.190072003131933 3862 762456
SGTC_1888 azatryptophan 97.5 µM -0.879133166736855 0.207490066982336 no 2663 0.18966453822256 3990 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_352 k048-0007 5.11 µM -0.88074950688893 0.207062180997378 no 2664 0.189226707318876 3956 6811911
SGTC_130 0136-0219 337.655 µM -0.882169286566879 0.206686760558237 no 2665 0.188842634143155 3824 234244
SGTC_2442 5158906 48.48 µM -0.883626091192636 0.206301969192577 no 2666 0.188449044840546 3977 1893835
SGTC_527 4476-4215 268 µM -0.883834753875187 0.206246889104571 no 2667 0.188392711265017 3926 4418754
SGTC_1674 st016616 23.6 µM -0.884327245923923 0.206116921966292 no 2668 0.188259792231382 3920 625830
SGTC_2287 7945887 168.79 µM -0.885531556418435 0.205799312757948 no 2669 0.187935003826113 3969 1245853
SGTC_1312 1218-2183 165 µM -0.885887006802433 0.205705626422697 no 2670 0.18783920919195 3948 6744073
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.886038504451683 0.205665703763314 no 2671 0.187798389419914 3889 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_3105 9121040 49.47 µM -0.886131585790531 0.205641177250549 no 2672 0.187773312150488 3775 41448907
SGTC_2898 9056270 58.44 µM -0.886224684757357 0.20561664782961 no 2673 0.187748232200798 3888 19154699
SGTC_499 genistein 192 µM -0.886570359216786 0.205525585815778 no 2674 0.187655128992386 3975 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1261 0712-0010 12.7 µM -0.887266355872258 0.205342310078396 no 2675 0.187467757313661 3965 2840123
SGTC_955 1216-0110 33 µM -0.888018502130329 0.205144357732856 no 2676 0.187265399452869 3911 3619719
SGTC_482 fipronil 114 µM -0.888452529897407 0.205030180483981 no 2677 0.187148689851403 4018 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_49 0717-0965 32.132 µM -0.889798008954598 0.204676472986569 no 2678 0.186787177942673 3988 5889349 YGL099W LSG1
SGTC_1483 3453-0561 55.9 µM -0.890447276547846 0.204505919607103 no 2679 0.18661288329377 3965 4546991
SGTC_2140 5586273 200 µM -0.890554487341068 0.204477764992063 no 2680 0.186584112450642 3924 854421
SGTC_855 0428-0020 25 µM -0.891292381609307 0.204284049243233 no 2681 0.186386167349471 3985 6812414
SGTC_709 3807-1509 243 µM -0.897693788851678 0.202608110015555 no 2682 0.184674410854145 4022 1886677 YPL242C IQG1
SGTC_2944 9067346 25.62 µM -0.898310459210308 0.202447095941457 no 2683 0.184510028988096 3926 6473075
SGTC_634 1611-4317 11.2 µM -0.899149859752522 0.202228049488348 no 2684 0.184286421661287 3960 2843522
SGTC_2915 7971052 15.16 µM -0.900456246376947 0.201887422479559 no 2685 0.183938749841162 3847 5741558
SGTC_3297 9117502 71.43 µM -0.904677614929455 0.200789094205674 no 2686 0.182818101746366 3987 7453720
SGTC_1040 k898-0338 155 µM -0.904741184340295 0.20077258198248 no 2687 0.182801258591904 3966 20969351
SGTC_2303 7774051 200 µM -0.904941240921867 0.200720622387733 no 2688 0.182748258540107 3971 2953184
SGTC_210 3551-0445 56.827 µM -0.905615245402531 0.200545626330265 no 2689 0.182569768308761 4009 2865180 YOR207C RET1
SGTC_2916 7875993 68.79 µM -0.906806156524723 0.200236646569443 no 2690 0.182254656828752 3858 1299250
SGTC_1846 st056244 14.8 µM -0.907980595525673 0.199932220799228 no 2691 0.181944236911151 4005 5393182
SGTC_2555 cholic acid 100 µM -0.912841990760899 0.198675064157172 no 2692 0.180662825136512 3978 6708657 Influences liver metabolism.
SGTC_3 0833-0587 95.581 µM -0.914131647432272 0.19834236072492 no 2693 0.180323837482897 3905 5382644
SGTC_1019 4262-0212 3.4 µM -0.916232559245122 0.197801091616613 no 2694 0.179772465866437 4013 4677213
SGTC_1209 2323-2347 50.3 µM -0.916484442954765 0.197736257442806 no 2695 0.179706431683818 3988 5412760
SGTC_2288 7946289 167.31 µM -0.916710369381168 0.197678115528692 no 2696 0.179647215465447 4048 1246052
SGTC_23 0213-0011 39.996 µM -0.917033460275828 0.197594986402568 no 2697 0.179562553360082 3987 627608
SGTC_2094 5332512 191.667 µM -0.918048632738207 0.197333926861639 no 2698 0.179296702768629 4035 755774
SGTC_481 bay k-8644 50 µM -0.918474138451994 0.197224566812065 no 2699 0.179185346147328 3955 2303 A calcium channel antagonist.
SGTC_2966 9084041 48.03 µM -0.918484837347942 0.197221817540683 no 2700 0.179182546762368 3905 17741380
SGTC_1346 1488-2224 62.4 µM -0.92088959161592 0.196604461633883 no 2701 0.178554036632615 3985 3722427
SGTC_1596 piperlongumine 63 µM -0.9211202817134 0.196545299768136 no 2702 0.178493816202812 4036 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_460 trequinsin 123 µM -0.9220530539558 0.196306194710626 no 2703 0.178250451409177 4033 5537 A vasodilator.
SGTC_1412 3909-8563 178 µM -0.922915165577652 0.196085359543227 no 2704 0.178025708359141 4070 23767530
SGTC_1272 0839-0021 27 µM -0.924889799395157 0.195580113123402 no 2705 0.177511616586391 4016 5027250
SGTC_2718 lomofungin 53.02 µM -0.928748521917966 0.194595072303229 no 2706 0.176509714101866 3980 5351222 A RNA synthesis inhibitor.
SGTC_149 3970-0822 46.1 µM -0.929985120299754 0.194280037788499 no 2707 0.176189394336845 4024 3114250 YBL034C STU1
SGTC_1692 fluoroquinolonic acid 71 µM -0.931469404423155 0.19390231349374 no 2708 0.175805401960438 4054 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_54 0159-0055 9 µM -0.931686674133264 0.193847059737567 no 2709 0.175749237615132 3981 3319099
SGTC_1305 1181-0477 144 µM -0.932737116376247 0.19358005766019 no 2710 0.175477858039163 4058 6252086
SGTC_1339 1486-1321 22.7 µM -0.932845202620418 0.193552596962508 no 2711 0.175449949261283 4017 3469382
SGTC_835 0312-0010 67.2 µM -0.933343052726107 0.193426142431192 no 2712 0.17532143650385 3963 1626196
SGTC_2096 5468907 200 µM -0.934358344898153 0.193168413243459 no 2713 0.175059538638265 4048 759785
SGTC_2844 9010103 25.97 µM -0.93461759911112 0.193102635872468 no 2714 0.174992702984369 4061 2480525
SGTC_2772 vinpocetine 57.06 µM -0.935468061399416 0.19288695460021 no 2715 0.17477356776353 4029 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2975 9084847 53.72 µM -0.936930406778672 0.192516441068919 no 2716 0.174397178530278 4088 27211724
SGTC_263 alizarin 107.927 µM -0.94002285202014 0.191734344301148 no 2717 0.173602919514388 4031 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2904 7225135 42.03 µM -0.940441514728062 0.191628611884021 no 2718 0.173495567983028 4127 4446116
SGTC_2693 st077581 40.7 µM -0.941668866080608 0.191318852657936 no 2719 0.173181099839511 4073 25238761
SGTC_1946 st076057 65.1 µM -0.942303625976264 0.19115877227564 no 2720 0.173018606139581 3947 953009
SGTC_832 4083-0019 164 µM -0.946646191682355 0.190065822802359 no 2721 0.171909548917205 4092 1990758
SGTC_288 1315-0019 35.1 µM -0.947856040571687 0.189762009912204 no 2722 0.171601373280967 4099 6811474
SGTC_3044 9093193 49.47 µM -0.948802661490162 0.189524506263011 no 2723 0.171360493999845 4065 25236277
SGTC_350 k064-0020 19.8 µM -0.94890402281887 0.189499085930012 no 2724 0.171334714185937 4046 2790705
SGTC_1702 st027038 51 µM -0.949791590885581 0.189276583017945 no 2725 0.171109079772987 4055 5521182
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.950027875218572 0.189217376423818 no 2726 0.171049044450523 4093 165506
SGTC_401 neomycin 50 µM -0.950180216028839 0.189179209899333 no 2727 0.171010344713618 4004 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1874 staurosporine 7.6 µM -0.950210607986137 0.189171596253537 no 2728 0.17100262479504 4071 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_690 glyoxal 20.3 µM -0.951667273281792 0.188806900799229 no 2729 0.170632875911477 3838 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.953470314857339 0.188356085987644 no 2730 0.170175914895721 3988 16623 A steroid.
SGTC_1060 3448-7350 82 µM -0.955044382979856 0.187963064803794 no 2731 0.169777626393955 4008 570178
SGTC_1501 4491-0275 38.4 µM -0.956379128530983 0.187630195867592 no 2732 0.169440362755459 3962 5104718
SGTC_1767 st044992 70.3 µM -0.960755809742329 0.186541263393063 no 2733 0.168337481224328 4100 9600693
SGTC_2517 totarol 10 µM -0.961386701696785 0.186384618790948 no 2734 0.168178884111479 4063 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2370 9071495 200 µM -0.962317161194294 0.18615374311643 no 2735 0.167945155551358 4051 21791103
SGTC_2074 5212007 75.395 µM -0.9630479069967 0.18597254688713 no 2736 0.167761741110907 3896 758611
SGTC_29 0299-0004 12.984 µM -0.964359191467957 0.185647674183351 no 2737 0.167432937171425 3936 16871 A napthoquinone isolated from Swertia calycina.
SGTC_3253 9135987 49.47 µM -0.966212590430329 0.185189092790603 no 2738 0.166968907015794 4054 4182430
SGTC_1492 4158-0558 28.5 µM -0.967057577897204 0.184980253564845 no 2739 0.166757625473649 4033 3967268
SGTC_468 gf-109203x 121 µM -0.967935452533879 0.184763441305185 no 2740 0.166538303574035 4016 2396 A protein kinase C inhibitor.
SGTC_586 0957-0265 8.15 µM -0.968780733259271 0.184554828242804 no 2741 0.166327300741339 3937 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_451 chloral hydrate 100 µM -0.969332893219722 0.18441863574399 no 2742 0.166189561312961 4086 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_590 k048-0076 22.4 µM -0.969411552324992 0.184399239244925 no 2743 0.166169945351288 4079 6832814
SGTC_597 k018-0003 82.8 µM -0.969618436493308 0.184348229867606 no 2744 0.166118359838776 4118 6786234
SGTC_353 1988-1175 58.3 µM -0.970059613691031 0.18423948250797 no 2745 0.166008389112825 3902 2788357
SGTC_1181 1222-0449 220 µM -0.972111962759804 0.183734116587147 no 2746 0.165497425716562 4117 658318
SGTC_308 4092-1169 104 µM -0.973595502628662 0.183369351275334 no 2747 0.165128710128236 3989 2268590 YDL196W YDL196W
SGTC_1654 st012436 41.8 µM -0.97434863484798 0.183184347822162 no 2748 0.164941732032912 3990 4323132
SGTC_1211 1056-0033 32.3 µM -0.975249719441143 0.182963153581079 no 2749 0.164718202422908 4115 6741922
SGTC_3197 9113331 49.47 µM -0.975684230192059 0.18285655139993 no 2750 0.164610484687527 4087 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_69 0096-0274 206.684 µM -0.976919933865869 0.182553597761533 no 2751 0.16430439613443 4213 6741392
SGTC_1402 3909-7673 35.9 µM -0.977500695429605 0.182411322599699 no 2752 0.164160666822859 4062 5328014
SGTC_2323 6148992 148.28 µM -0.979517907974001 0.181917683581033 no 2753 0.163662072322068 4036 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3183 9108214 49.47 µM -0.9802776472602 0.181731981951298 no 2754 0.163474542671645 3993 4974831
SGTC_1690 st023502 41.2 µM -0.980355356069817 0.18171299442265 no 2755 0.163455369348834 4064 24207482
SGTC_1509 1326-1131 80 µM -0.980906788629694 0.181578291925951 no 2756 0.163319354731196 4001 768313
SGTC_2667 digitoxin 100 µM -0.98138011001283 0.18146272007706 no 2757 0.163202665431186 3980 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1921 5740136 50 µM -0.987329060257121 0.180014081321139 no 2758 0.161740674408555 4015 1774243
SGTC_2505 galangin 7.89 µM -0.991083715201895 0.179103527553877 no 2759 0.160822352048988 3960 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3226 9131256 49.47 µM -0.992310270257296 0.178806700612437 no 2760 0.160523097437649 4008 17178073
SGTC_653 0203-0016 55.2 µM -0.99371746174725 0.178466541228935 no 2761 0.1601802195598 4124 295302
SGTC_3101 9120531 49.47 µM -0.996479282974356 0.177800114230509 no 2762 0.159508664045691 4106 24824904
SGTC_2835 9006588 71.43 µM -0.996780969361717 0.177727412580112 no 2763 0.159435418774555 4158 2345538
SGTC_1983 st071813 46.9 µM -0.998418912719037 0.177333021532078 no 2764 0.159038133209917 4145 11838595
SGTC_2875 9039966 71.43 µM -1.00112624054781 0.176682352117807 no 2765 0.158382890150071 4098 6463691
SGTC_770 0389-1121 67.2 µM -1.00272891430845 0.176297883500339 no 2766 0.157995837532735 4192 6753108
SGTC_3127 9126946 49.47 µM -1.00294787673195 0.176245397301239 no 2767 0.157943005421356 4094 27243249
SGTC_1562 morin hydrate 59.1 µM -1.003336961944 0.176152156366628 no 2768 0.157849154039796 4163 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1297 1068-0111 14.1 µM -1.00388102243968 0.176021829299557 no 2769 0.15771798243736 4058 767057
SGTC_3344 9148862 3.898 µM -1.00694506251987 0.175288993784187 no 2770 0.156980587669913 4152 4905352
SGTC_1559 coumarin 343 70.1 µM -1.00706491124184 0.17526036858322 no 2771 0.156951790928302 4128 108770 A hepatotoxic, DNA x-linker.
SGTC_1416 3966-0321 25.3 µM -1.00754493126575 0.175145748184244 no 2772 0.156836488592648 4122 582530 YLR208W SEC13
SGTC_322 k048-0136 19.3 µM -1.00874208618921 0.174860095711199 no 2773 0.156549171078788 4175 6823282
SGTC_3354 9151612 71.43 µM -1.01010489455086 0.174535276859556 no 2774 0.156222518747503 4125 27261949
SGTC_479 n-linoleoylglycine 10 µM -1.01089459578252 0.174347230826019 no 2775 0.156033440434073 4134 6433346 An anti-infammatory.
SGTC_757 1066-0008 322 µM -1.01233779513627 0.174003904565509 no 2776 0.155688284772968 4127 6842497
SGTC_1838 st055369 84.5 µM -1.01453617758317 0.173481752622199 no 2777 0.15516348787481 4106 676036
SGTC_1781 st038725 66.3 µM -1.01590005681563 0.173158310704992 no 2778 0.154838490907263 4085 4270275 YIL048W NEO1
SGTC_1118 chelidonine 707.474 nM -1.01959954214289 0.172282918522626 no 2779 0.153959211120486 4108 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2941 9056145 11.23 µM -1.02044662113524 0.172082876089871 no 2780 0.153758346354395 4012 2119517
SGTC_689 0833-0039 98 µM -1.02106485569951 0.171936970174166 no 2781 0.153611856193073 4070 5374726
SGTC_2843 9000894 45.46 µM -1.02135800997782 0.171867812166424 no 2782 0.153542425843251 4029 2242070
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.02222339177596 0.171663763630978 no 2783 0.153337590972779 4132 115019
SGTC_961 1252-1571 372 µM -1.02246430100239 0.171606987149269 no 2784 0.153280600266573 4131 6813498
SGTC_3320 9137005 35.139 µM -1.02852037973884 0.170183658699432 no 2785 0.151852554671021 4135 4908713
SGTC_2492 derrusnin 100 µM -1.03004645404434 0.169826190105531 no 2786 0.151494099645599 4099 1715307 Part of coumarin class of compounds.
SGTC_3185 9108267 49.47 µM -1.03038162911689 0.169747743020757 no 2787 0.151415446786479 4130 4910486
SGTC_1160 4092-0570 10.5 µM -1.03291954848578 0.169154502215613 no 2788 0.150820774845622 4121 4994975
SGTC_1808 st050063 61.5 µM -1.03322676045897 0.169082781591009 no 2789 0.150748896189072 4118 4011993
SGTC_1235 benzylparaben 21.5 µM -1.03348817742335 0.169021767489105 no 2790 0.150687750195929 4139 7180
SGTC_848 0368-0089 85.6 µM -1.04209250731247 0.167021432442556 no 2791 0.148684396029534 4136 762535
SGTC_1643 st009866 20.2 µM -1.04242110321823 0.166945344316616 no 2792 0.148608243325425 4076 3156273 YOR207C RET1
SGTC_2953 9074162 66.49 µM -1.04574913336317 0.166175981395397 no 2793 0.147838435811918 4139 16451992
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.04927515508782 0.16536335031175 no 2794 0.14702574868702 4243 688801
SGTC_2105 5350118 200 µM -1.0517866882161 0.16478609586265 no 2795 0.14644871390869 4116 2133313
SGTC_3076 9116187 49.47 µM -1.05200967325816 0.164734907820234 no 2796 0.146397555786625 4133 27241210
SGTC_1490 4089-0339 670 nM -1.05202507479085 0.164731372652642 no 2797 0.146394022748291 4106 742542
SGTC_37 0566-0070 1.56 µM -1.05299589675057 0.164508635687346 no 2798 0.146171436334336 4105 1626686
SGTC_2688 kanamycin b 96.69 µM -1.05580730217052 0.163864712889719 no 2799 0.14552813070836 4206 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_3025 9087895 49.47 µM -1.05601027225477 0.163818288121519 no 2800 0.145481760908442 4137 17173641
SGTC_280 3448-3607 3.04 µM -1.06007166145387 0.162891132772756 no 2801 0.144555999478449 4120 626179
SGTC_799 1310-0557 151 µM -1.06031425372608 0.162835860725809 no 2802 0.144500828390038 4218 5354492
SGTC_176 1486-1328 72.834 µM -1.06185348574234 0.162485447447744 no 2803 0.14415110208247 4225 22310231
SGTC_807 1315-0151 48 µM -1.06264394723008 0.162305686085857 no 2804 0.143971724633557 4192 4011080
SGTC_1398 3558-0053 112 µM -1.06372747549332 0.162059487915596 no 2805 0.143726086991431 4071 4532369
SGTC_1882 5615643 20 µM -1.06938704887754 0.160777480909129 no 2806 0.14244765033517 4116 2253075
SGTC_3144 9087057 49.47 µM -1.07069201487907 0.160482821934436 no 2807 0.142153967191322 4057 17249618
SGTC_3156 9099931 49.47 µM -1.07395827751639 0.159746853382536 no 2808 0.141420690865807 4193 18111053
SGTC_1892 st058411 7.36 µM -1.07422370299046 0.159687143725508 no 2809 0.141361215640731 4181 3934738
SGTC_592 k241-0073 46.5 µM -1.07480533524853 0.159556351806066 no 2810 0.141230945652141 4205 4230158
SGTC_1929 genistein trimethyl ether 50.5 µM -1.07904256759566 0.158605639981854 no 2811 0.14028437598352 4166 136420
SGTC_2407 paclitaxel 400 µM -1.08211252451927 0.15791915625037 no 2812 0.139601265625285 4286 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1062 mesoridazine 14.2 µM -1.08476498210591 0.157327604399164 no 2813 0.139012879368182 4199 4078 A neuroleptic.
SGTC_2469 5655019 90.81 µM -1.08498417636221 0.157278784881344 no 2814 0.138964331834565 4231 2788239
SGTC_3259 9138485 49.47 µM -1.08546259618327 0.157172264564071 no 2815 0.138858410657682 4185 17646153
SGTC_559 1550-0661 158 µM -1.08558695673971 0.157144583419101 no 2816 0.13883088648827 4231 5830875
SGTC_569 4130-2812 160 µM -1.08663716633751 0.156910947421067 no 2817 0.138598596437385 3993 743552
SGTC_1222 0366-0074 1.18 µM -1.08688867602621 0.156855028986504 no 2818 0.138543005724309 4198 286520
SGTC_553 k007-0256 45.7 µM -1.08705607780643 0.156817817627703 no 2819 0.138506013646166 4231 6287000
SGTC_3014 9081533 49.47 µM -1.08841815488432 0.156515260570177 no 2820 0.138205275018582 4224 21367265
SGTC_2415 st077333 57.7 µM -1.08885987225066 0.156417224843842 no 2821 0.138107842087766 4247 2766255
SGTC_1379 2144-0755 36.5 µM -1.08958438688265 0.156256512049879 no 2822 0.137948131874716 4240 5392327
SGTC_343 4130-2827 29.8 µM -1.09024407001313 0.156110274912408 no 2823 0.137802822575024 4201 1118244
SGTC_1790 st045711 43.5 µM -1.09147334971071 0.15583801151338 no 2824 0.137532326177212 4185 585119
SGTC_2852 9023854 51.95 µM -1.09253493402858 0.155603141696744 no 2825 0.137299022098014 4236 19798528
SGTC_2462 5162487 171.77 µM -1.09315458911917 0.155466154319228 no 2826 0.137162965678211 4108 2259986
SGTC_321 4534-3890 65.3 µM -1.09361805077146 0.155363748709392 no 2827 0.137061264560557 4183 699746
SGTC_906 1165-0455 526 µM -1.09384292856032 0.155314076181621 no 2828 0.137011936388003 4161 3252859
SGTC_771 0250-0039 27.3 µM -1.09620396464862 0.154793187316553 no 2829 0.136494762498717 4156 3005115
SGTC_249 wiskostatin 11.211 µM -1.09675852746338 0.154671007921269 no 2830 0.136373482005323 4155 2775510 A n-wasp and actin depolymerizer.
SGTC_1109 tnp00067 928.257 nM -1.09681009615199 0.154659649722305 no 2831 0.136362207903382 4188 676295
SGTC_1997 st073024 93.8 µM -1.09683495670428 0.154654174288422 no 2832 0.136356773042403 4195 686268
SGTC_2991 9074669 71.4286 µM -1.0968779722536 0.154644700594064 no 2833 0.136347369597724 4182 17333109
SGTC_300 r073-0011 5.04 µM -1.09912754599008 0.154149791557243 no 2834 0.135856218159975 4184 2735780
SGTC_2252 omeprazole 400 µM -1.10200138799488 0.153519068468807 no 2835 0.13523053409345 4162 4594 A proton pump inhibitor.
SGTC_1078 idebenone 36.1 µM -1.10240562482005 0.153430487779582 no 2836 0.135142683629954 4239 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1899 st063254 59.6 µM -1.10444596873612 0.152983902619683 no 2837 0.134699864713959 4142 3093813
SGTC_447 ml7 120 µM -1.10523418113803 0.152811611731187 no 2838 0.13452906471487 4228 4216 Selective myosin light chain kinase inhibitor.
SGTC_2890 9046729 58.44 µM -1.10535791327611 0.152784577513306 no 2839 0.134502266350806 4156 903329
SGTC_891 0929-0073 133 µM -1.10613326344982 0.152615243578881 no 2840 0.13433442157754 4235 5603632
SGTC_2700 st077718 96.8 µM -1.10859644463773 0.152078119256997 no 2841 0.133802156291335 4191 904970
SGTC_3248 9135562 49.47 µM -1.11087958548204 0.151581377238796 no 2842 0.13331009188096 4192 17650701
SGTC_3336 9143619 71.43 µM -1.11369440847426 0.150970443566415 no 2843 0.132705154456726 4243 45595730
SGTC_2646 retinol 96.75 µM -1.11504301411578 0.150678321502823 no 2844 0.132415994750463 4219 445354 A vitamin A analog and teratogen.
SGTC_2918 7977171 22.06 µM -1.11604162528814 0.150462254604966 no 2845 0.132202158694145 4197 2236483
SGTC_90 0870-0863 4.608 µM -1.11607362919282 0.150455333418675 no 2846 0.132195309526935 4237 1738164
SGTC_214 4373-3496 70 µM -1.11743789851825 0.150160492828316 no 2847 0.131903569222118 4288 3779166
SGTC_1887 st057648 70.8 µM -1.12048966762796 0.149502351534925 no 2848 0.131252576587549 4220 688672
SGTC_2414 st077232 92.9 µM -1.12439722506349 0.148662466599504 no 2849 0.130422274373366 4158 729801
SGTC_164 4100-3994 89.624 µM -1.12479199874407 0.148577790265973 no 2850 0.13033859290161 4191 4615967
SGTC_701 4424-0219 185 µM -1.12488196866065 0.148558496829067 no 2851 0.130319526881455 4262 2911779
SGTC_3261 9137475 49.47 µM -1.12489379686811 0.14855596047499 no 2852 0.130317020444426 4156 17027690
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.12547081049617 0.148432265060951 no 2853 0.13019478980498 4264 91467 include heat shock
SGTC_162 k030-0015 37.8 µM -1.13062480201103 0.147330450845127 no 2854 0.129106521950729 4292 1809920 YMR134W ERG29
SGTC_1568 digitonin 820 nM -1.1322887546872 0.146975906473713 no 2855 0.128756528143863 4223 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_419 nsc-638432 893 µM -1.13244128349945 0.146943435265126 no 2856 0.128724478383388 4172 368090
SGTC_1184 1269-1718 139 µM -1.13539028303064 0.146316581079184 no 2857 0.128105914596306 4279 5403821
SGTC_1972 st070201 17.4 µM -1.13700126843906 0.145974901394959 no 2858 0.127768877701827 4241 2829099
SGTC_1450 4112-4260 37.6 µM -1.13701689726037 0.145971589250002 no 2859 0.127765610991804 4235 1633175
SGTC_1635 st007035 42.4 µM -1.13858647317488 0.145639213343448 no 2860 0.127437836481527 4201 3716403
SGTC_844 0330-0132 15.3 µM -1.14033954973334 0.145268581043379 no 2861 0.127072433397314 4277 2828079
SGTC_1648 st011736 69.8 µM -1.14283160364695 0.144742808605205 no 2862 0.126554257245872 4230 2855514
SGTC_2198 6589944 200 µM -1.14288799144687 0.144730926778271 no 2863 0.12654254950741 4227 5290268
SGTC_2739 tacrine 100.86 µM -1.14368238816274 0.144563604281966 no 2864 0.126377689950555 4287 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_497 capsazepine 133 µM -1.14421398382212 0.144451707960205 no 2865 0.126267452585408 4194 2733484 A calcium channel blocker.
SGTC_1362 1611-0397 101 µM -1.14489272816387 0.144308922957306 no 2866 0.126126798326407 4198 27816
SGTC_1 0258-0098 57.368 µM -1.14506481378587 0.144272737047063 no 2867 0.126091154875332 4186 6790032 YDR047W HEM12
SGTC_1761 st044296 37 µM -1.146563367254 0.143957881991426 no 2868 0.125781061923152 4225 1826700
SGTC_1456 k015-0012 13 µM -1.14665361029674 0.143938936194196 no 2869 0.125762405090161 4266 2989616
SGTC_3107 9121808 49.47 µM -1.14801676079914 0.143652958338275 no 2870 0.125480822352116 4173 662681
SGTC_1691 st019933 84.6 µM -1.14960878800067 0.143319449754973 no 2871 0.125152518500021 4232 6176082
SGTC_1714 st033236 13.627 µM -1.15079295857689 0.143071721086405 no 2872 0.124908711157391 4287 2916566
SGTC_2851 9015922 71.43 µM -1.15238649877386 0.142738809078497 no 2873 0.124581143241994 4267 2996893
SGTC_773 4358-1457 44.6 µM -1.15275392739065 0.14266212264737 no 2874 0.124505699934478 4254 1186886
SGTC_2884 9058502 51.95 µM -1.15449261091176 0.142299617932262 no 2875 0.124149133100924 4272 6471554
SGTC_989 1501-0895 10.3 µM -1.15522746391693 0.142146593174528 no 2876 0.123998645437903 4214 2830112
SGTC_587 k089-0003 57 µM -1.15679954126674 0.141819600093412 no 2877 0.123677134659384 4140 9659696
SGTC_3228 9131799 49.47 µM -1.15954770225154 0.141249205301297 no 2878 0.123116502087254 4256 17015818
SGTC_517 1365-0151 113 µM -1.16048798367753 0.141054402697251 no 2879 0.122925091651398 4294 768657
SGTC_2111 5486399 200 µM -1.16194170644796 0.140753586740757 no 2880 0.122629572243645 4202 689674
SGTC_1432 4049-0298 68.4 µM -1.16288315928894 0.140559006189669 no 2881 0.122438455511329 4278 741646
SGTC_1996 st072960 66.8 µM -1.16334211547051 0.140464214835538 no 2882 0.122345362351831 4290 1719405
SGTC_3090 9117696 49.47 µM -1.16408009972464 0.140311884928443 no 2883 0.122195776245014 4215 7923821
SGTC_2708 st078559 56 µM -1.16564332458983 0.139989584853923 no 2884 0.121879341739467 4186 17250902
SGTC_3265 9137266 49.47 µM -1.16571361194372 0.139975105088399 no 2885 0.121865127415076 4203 17224265
SGTC_361 000s-0510 1.45 µM -1.16613249938312 0.139888831982453 no 2886 0.121780439287095 4182 660
SGTC_3214 9129694 49.47 µM -1.16636715415612 0.139840518814604 no 2887 0.121733016278638 4291 17158655
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.16931543942972 0.139234461592306 no 2888 0.121138282444143 4256 1377
SGTC_1976 st070609 63.5 µM -1.16988030598469 0.139118550482892 no 2889 0.121024570164294 4205 682556
SGTC_1271 0832-2808 169 µM -1.17495336169397 0.138080498787901 no 2890 0.120006687559154 4299 3663794
SGTC_1516 st013856 110 µM -1.17541265210229 0.137986779951043 no 2891 0.119914832064846 4308 5281404 A mutagen and neurotoxin.
SGTC_2191 5911152 200 µM -1.17943220004796 0.137168437093825 no 2892 0.119113059753801 4267 2875902
SGTC_1270 0831-1170 17.3 µM -1.18030997361008 0.136990172450771 no 2893 0.118938476409205 4278 6764716
SGTC_930 2810-3379 265 µM -1.18274440376669 0.136496599310513 no 2894 0.118455230186323 4292 1015764
SGTC_1995 st072814 61.1 µM -1.18562079275394 0.1359149897278 no 2895 0.117886043568733 4227 5769371
SGTC_2757 clomiphene 4.22 µM -1.18601573642113 0.135835264292081 no 2896 0.117808042530979 4286 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2465 5809242 33.21 µM -1.18866603892252 0.135301088666095 no 2897 0.11728555482262 4320 2731748
SGTC_1877 wortmannin 25 µM -1.19174753441382 0.134681817557347 no 2898 0.116680126704305 4279 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2856 9022925 19.48 µM -1.19421027504941 0.134188294748302 no 2899 0.116197862392505 4318 4944862
SGTC_1404 3909-7820 48.3 µM -1.1943495020154 0.134160431399207 no 2900 0.116170640685917 4252 23741373
SGTC_2982 9019404 25.97 µM -1.19517090200234 0.133996126358934 no 2901 0.116010132379552 4225 22333232
SGTC_790 1575-0012 79.1 µM -1.19539847967177 0.133950628358043 no 2902 0.115965689697913 4341 378741 YLR208W SEC13
SGTC_2794 7785382 27.27 µM -1.20097847445101 0.132838379824302 no 2903 0.114879775664475 4272 2205081
SGTC_1751 st044839 27.194 µM -1.20274497322263 0.132487596470599 no 2904 0.114537512306118 4317 5291326
SGTC_791 1348-1292 225 µM -1.20449854198964 0.132140012495455 no 2905 0.114198472628924 4265 5437054
SGTC_598 3937-0236 20.2 µM -1.2047311004942 0.132093963130387 no 2906 0.114153562881639 4344 1379313
SGTC_2276 7947513 42.08 µM -1.2066995444678 0.131704630903892 no 2907 0.113773937294828 4234 2105100
SGTC_676 falcarinol 140 µM -1.20672386269112 0.131699826037175 no 2908 0.113769253021024 4324 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2960 9079389 5.97 µM -1.20848053992707 0.131353056464934 no 2909 0.113431238330733 4290 16457355
SGTC_641 4092-0595 30 µM -1.2087376474089 0.131302356168089 no 2910 0.113381826607318 4348 786260
SGTC_110 0850-0284 111.64 µM -1.20918474567885 0.131214222833169 no 2911 0.113295938420503 4112 3906265
SGTC_2451 5856223 45.7 µM -1.20970522585471 0.131111675716766 no 2912 0.113196011943477 4267 2179896
SGTC_1698 5-fluorocytosine 1.055 µM -1.20973852929742 0.131105116022383 no 2913 0.11318962018941 4306 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_79 0052-0007 94.094 µM -1.20980001017622 0.131093006885694 no 2914 0.11317782116517 4295 2801472
SGTC_2663 amphotericin b 100 µM -1.21152928770352 0.130752728703561 no 2915 0.112846308483367 4303 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1175 0741-0056 27.6 µM -1.21314451519493 0.130435444612902 no 2916 0.112537286559982 4372 765927
SGTC_803 4488-1585 147 µM -1.21475113108738 0.130120380781947 no 2917 0.112230512297809 4285 747204
SGTC_3168 9103419 49.47 µM -1.21741328997379 0.12959948086298 no 2918 0.111723504531903 4326 16649256
SGTC_1758 st042942 75.2445 µM -1.22665488919876 0.127802412704742 no 2919 0.109976164741851 4275 669317
SGTC_1168 k815-0004 80.5 µM -1.22935365323719 0.127280909247154 no 2920 0.109469619541878 4286 642433
SGTC_870 0573-2213 57.6 µM -1.23032040270243 0.127094457243125 no 2921 0.109288573512227 4303 3916321
SGTC_3215 9129942 49.47 µM -1.2306916635163 0.127022904612324 no 2922 0.109219103600159 4291 17682944
SGTC_1980 st071811 45.7 µM -1.23583144569555 0.126035200935914 no 2923 0.108260611817678 4386 4974850
SGTC_1006 4099-6547 255 µM -1.23641160592387 0.125924049725352 no 2924 0.108152802123483 4321 3146833
SGTC_618 k072-0232 33.2 µM -1.23655420784303 0.125896739507757 no 2925 0.1081263146097 4364 5872756 YGL099W LSG1
SGTC_1521 st012942 49.4 µM -1.2367728986043 0.125854865261511 no 2926 0.108085703089349 4267 24207259
SGTC_1254 0550-0035 264 µM -1.23864351657646 0.125497081871695 no 2927 0.107738772453791 4325 15121435
SGTC_2425 5628681 7.85 µM -1.23865910470304 0.125494103396921 no 2928 0.107735884805475 4385 5714958
SGTC_2466 5983409 37.09 µM -1.24023474645254 0.125193294815744 no 2929 0.107444290022227 4317 2879657
SGTC_2083 5306046 65.942 µM -1.24111750180965 0.125024986642387 no 2930 0.107281172495273 4311 539837
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.24119460694405 0.125010293108475 no 2931 0.107266933317499 4205 4000243
SGTC_1567 st069303 68.4 µM -1.24122600278143 0.125004310508762 no 2932 0.107261135768319 4354 5581319
SGTC_231 b-estradiol 524 µM -1.24374173336979 0.124525578125028 no 2933 0.106797315529087 4293 450 A steroid.
SGTC_276 colchicine 750 µM -1.25107961755352 0.123136538479481 no 2934 0.105452715543466 4380 2833 A microtubule depolymerizer.
SGTC_2174 5790901 200 µM -1.25126062306925 0.123102412466823 no 2935 0.105419703394737 4319 786020
SGTC_515 4092-1064 102 µM -1.25129272734265 0.123096360355435 no 2936 0.105413848933608 4327 717353
SGTC_1881 5652484 16 µM -1.25233051223619 0.12290083549332 no 2937 0.105224727533566 4308 2255129
SGTC_56 0957-0365 83.25 µM -1.25371047973062 0.122641178844368 no 2938 0.104973628716923 4290 6752360
SGTC_2431 5490079 200 µM -1.2553427086731 0.122334553414687 no 2939 0.104677188712566 4374 5722345
SGTC_2245 6637752 200 µM -1.25557478420024 0.122291000162051 no 2940 0.104635089206729 4373 681890
SGTC_733 4069-0007 56.1 µM -1.25642377339353 0.122131764426585 no 2941 0.104481183388181 4349 5717425 YNL287W SEC21
SGTC_621 3584-0052 32.1 µM -1.25698533287382 0.122026518807765 no 2942 0.104379473349485 4359 2273927
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.2575364518501 0.121923291857558 no 2943 0.104279724082005 4365 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2301 7769476 200 µM -1.25927974143497 0.12159717016453 no 2944 0.103964653953193 4339 977820
SGTC_1237 0330-0133 46.1 µM -1.26083959580398 0.121305884309052 no 2945 0.103683322341922 4269 X1237 YHR072W ERG7
SGTC_2272 7805186 180 µM -1.26131684219206 0.121216861839289 no 2946 0.103597357772357 4353 2956062 YPR165W RHO1
SGTC_2216 7189485 200 µM -1.26187650947277 0.121112523654723 no 2947 0.103496612945433 4329 731273
SGTC_847 0342-0274 5.54 µM -1.26192643974609 0.121103218276645 no 2948 0.103487628531421 4338 18097
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.26192739732719 0.121103039819606 no 2949 0.103487456230566 4352 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1188 1403-0014 4.57 µM -1.26296745088803 0.120909322223583 no 2950 0.103300438722993 4335 9614867
SGTC_2229 7354935 190 µM -1.26416102050016 0.120687279973153 no 2951 0.103086119203447 4280 318112
SGTC_2743 auranofin 4.32 µM -1.26455117852124 0.120614760353539 no 2952 0.103016131809686 4361 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2320 7373003 200 µM -1.26485184030495 0.120558896552383 no 2953 0.102962221997482 4362 5415828
SGTC_2487 5918373 44.05 µM -1.26516913421991 0.120499962215838 no 2954 0.10290535221004 4397 2876279
SGTC_1427 4048-4900 550 nM -1.26532936361934 0.120470208834728 no 2955 0.102876642362857 4331 24132586
SGTC_3282 9108498 15.4605 µM -1.26791438804911 0.119990904404208 no 2956 0.102414262677022 4300 16459645
SGTC_285 1486-1325 46 µM -1.26815278516741 0.119946769598153 no 2957 0.102371697148874 4380 22310230
SGTC_2372 9071633 200 µM -1.26937944938079 0.119719856391964 no 2958 0.102152881078116 4386 21321366
SGTC_2285 7945142 200 µM -1.27647783397845 0.118412713293218 no 2959 0.100893328775445 4379 2970608
SGTC_2747 doxorubicin 7.63 µM -1.27933863239396 0.117888769704837 no 2960 0.100388916980683 4371 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2765 myclobutanil 7.74 µM -1.28041821943337 0.117691474651395 no 2961 0.100199044824917 4366 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2605 digitonin 300 nM -1.28389892283362 0.117056966146829 no 2962 0.0995886621051131 4361 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1413 3910-0535 34.4 µM -1.28681616025658 0.116527043781952 no 2963 0.0990791864586376 4387 2876951
SGTC_1851 st056236 18.9 µM -1.29046051863029 0.115867431767418 no 2964 0.0984454057258994 4344 5393171
SGTC_2724 maprotiline 69.64 µM -1.29053044384254 0.11585480160378 no 2965 0.0984332743099437 4300 4011 A tricyclic antidepressant.
SGTC_3230 9131665 49.47 µM -1.29154328170109 0.115671968519729 no 2966 0.0982576784971887 4344 15943720
SGTC_2309 7664088 163.95 µM -1.29622984095933 0.114828639603992 no 2967 0.0974481557884591 4353 704922
SGTC_3108 9121785 49.47 µM -1.29706295295588 0.114679183248104 no 2968 0.0973047635746204 4198 17140271
SGTC_525 k781-2675 26.7 µM -1.29880811344825 0.114366558498073 no 2969 0.0970048947785334 4317 3651118 YDL195W SEC31
SGTC_2711 st079103 59.1 µM -1.30123851841086 0.113932191998399 no 2970 0.0965884122554346 4309 54693780
SGTC_1003 4049-0218 100 µM -1.30283660994034 0.113647219448393 no 2971 0.0963152745635995 4370 295161
SGTC_3278 9139605 49.47 µM -1.30292692948309 0.113631128802854 no 2972 0.0962998545712599 4353 7958859
SGTC_2395 5646831 180.19 µM -1.30340206399476 0.113546509182497 no 2973 0.0962187661186008 4368 6808628
SGTC_1169 aniline yellow 25.8 µM -1.30422159974444 0.113400658637648 no 2974 0.0960790186691703 4293 6051 A DNA damaging agent.
SGTC_1539 benzyladenosine 56 µM -1.30688544554907 0.112927504391826 no 2975 0.0956258099248082 4371 92208 A nucleotide analog.
SGTC_2028 5153890 36.43 µM -1.30866467899003 0.112612261605142 no 2976 0.0953239806165565 4358 2830968 YPR165W RHO1
SGTC_873 0591-4978 488 µM -1.30881901029482 0.112584946992597 no 2977 0.0952978329362092 4419 3305145
SGTC_2545 solidagenone 89.61 µM -1.31807605557528 0.110955217063284 no 2978 0.0937390945635244 4262 6708572 An anti ulcer agent
SGTC_2744 captopril 92.04 µM -1.32017272516073 0.110588451185126 no 2979 0.0933886780530601 4438 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_235 0330-0087 5 mM -1.32329504067012 0.110043883160655 no 2980 0.0928686401509531 4435 46494818 YHR062C RPP1
SGTC_303 1348-1668 34.2 µM -1.32618659518319 0.109541280875069 no 2981 0.0923889491528034 4392 5380509
SGTC_2461 5755302 26.15 µM -1.326627910742 0.109464717806166 no 2982 0.0923158991961338 4404 2788904
SGTC_711 k292-0785 179 µM -1.33029797307513 0.108829493540916 no 2983 0.0917100573770267 4313 4146315
SGTC_3125 9127534 49.47 µM -1.33157633760497 0.10860885435562 no 2984 0.0914997223781408 4282 1639235
SGTC_2754 granisetron 64.02 µM -1.33361544527976 0.108257581026935 no 2985 0.0911649592260525 4388 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_3146 9095609 49.47 µM -1.33473134007306 0.108065694421467 no 2986 0.0909821461746459 4432 17173999
SGTC_2152 5568786 200 µM -1.33628192939842 0.107799465500668 no 2987 0.0907285703454844 4412 5399883
SGTC_3039 9090270 49.47 µM -1.33715519118972 0.1076497386593 no 2988 0.0905859924303076 4398 17173750
SGTC_2716 st080858 38.6235 µM -1.34013444181514 0.10714005300301 no 2989 0.0901008202362542 4366 5296050
SGTC_2788 5282734 71.43 µM -1.34472616950269 0.106357918978812 no 2990 0.089356840168793 4424 743706
SGTC_1039 k821-0043 94 µM -1.34733057209767 0.10591613365458 no 2991 0.0889368950192297 4372 15992768
SGTC_1652 st011932 78 µM -1.34818296715677 0.105771830172648 no 2992 0.0887997707704486 4334 1551076
SGTC_2293 7624732 200 µM -1.35416365645109 0.104763344086459 no 2993 0.087842085549127 4291 894453
SGTC_1784 st039334 36.3 µM -1.35449792844487 0.104707184074311 no 2994 0.0877887869239275 4414 3496984
SGTC_1772 st048439 82.2 µM -1.35499129782484 0.104624334442551 no 2995 0.0877101647999968 4451 2927068 YDL195W SEC31
SGTC_2148 5546263 113.568 µM -1.35503295950357 0.104617340531054 no 2996 0.0877035281039031 4421 792097
SGTC_114 0364-0001 490.298 µM -1.35510055367077 0.104605993950174 no 2997 0.087692761165231 4432 4003655
SGTC_2588 indole-3-carbinol 100 µM -1.35987436433375 0.103806899446743 no 2998 0.0869348423223657 4407 3712 Induces cell cycle arrest.
SGTC_1216 1165-0504 9.65 µM -1.36010063927733 0.103769133202803 no 2999 0.0868990394082325 4425 6304004
SGTC_2399 5884133 200 µM -1.36123466292132 0.103580010013328 no 3000 0.0867197716367373 4368 722445
SGTC_742 0kpi-0133 140 µM -1.3626980087131 0.103336334966997 no 3001 0.0864888528388928 4443 2728852
SGTC_3016 9080866 49.47 µM -1.36306408364049 0.103275441623985 no 3002 0.0864311574571803 4365 17066299
SGTC_1974 st069448 26.9 µM -1.36602362241696 0.102784104901922 no 3003 0.0859657745447227 4395 6323587 YNR016C ACC1
SGTC_1704 st028805 70.8 µM -1.37374251965267 0.101510626454854 no 3004 0.0847608157904869 4452 2876101
SGTC_2358 9037157 4 µM -1.37384533845501 0.101493741117772 no 3005 0.0847448511736464 4424 2388925
SGTC_1981 st071826 47 µM -1.37397058305864 0.1014731756848 no 3006 0.084725407561742 4450 11838600
SGTC_1875 nocodazole 6 µM -1.37406995569502 0.101456860644002 no 3007 0.0847099828265125 4457 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3205 9113483 49.47 µM -1.37411027922985 0.101450240854254 no 3008 0.084703724361616 4429 17018033
SGTC_761 k216-0224 480 µM -1.3748398373208 0.101330525896876 no 3009 0.0845905522649421 4416 1340404
SGTC_1507 4075-3230 155 µM -1.37602681774269 0.101135971396097 no 3010 0.0844066653454679 4374 659771
SGTC_604 1000-0114 314 µM -1.37638832125407 0.101076772525276 no 3011 0.0843507208755926 4433 1572745
SGTC_2336 9001819 198.65 µM -1.37752506538487 0.100890786854799 no 3012 0.0841749853662399 4456 2989602
SGTC_782 0083-0095 30.5 µM -1.38028312952764 0.100440570171591 no 3013 0.0837497436239648 4374 3591729 An indicator and reagent.
SGTC_369 0957-0393 4.5 µM -1.38064965867345 0.100380849770587 no 3014 0.083693353401544 4420 6997992
SGTC_2444 5485484 36.41 µM -1.38066737583744 0.100377963682388 no 3015 0.0836906283526174 4483 6790631
SGTC_107 0358-0022 2.6945 µM -1.38480473038574 0.0997056545810272 no 3016 0.0830560920592103 4453 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1884 5633444 25 µM -1.38497782544801 0.0996775989679236 no 3017 0.0830296239527441 4376 5724239
SGTC_656 4090-1979 187 µM -1.39348553246818 0.0983057519974427 no 3018 0.081736508477933 4450 22330961
SGTC_3284 9108171 64.8615 µM -1.39399865439445 0.0982234566981705 no 3019 0.081659005492634 4412 8687505
SGTC_1797 st048695 56.8 µM -1.39444340469834 0.0981521677823442 no 3020 0.0815918743308159 4383 592262 YIL048W NEO1
SGTC_2550 chrysin dimethyl ether 71.87 µM -1.39567975524582 0.0979541926172451 no 3021 0.0814054766736393 4265 88881 An O-methylated flavonoid and antioxidant.
SGTC_1764 st044502 93.5 µM -1.40229309747161 0.0969001746390725 no 3022 0.0804138703897144 4460 8407
SGTC_2328 6201408 200 µM -1.40241489811677 0.0968808407564973 no 3023 0.0803956935407042 4400 2890418
SGTC_2634 4'-methoxyflavone 100 µM -1.40356141444529 0.0966989886258365 no 3024 0.0802247459571217 4434 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.40415662947596 0.0966046788415033 no 3025 0.0801361067621726 4429 688662
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.40455547200899 0.096541521424649 no 3026 0.0800767527215776 4455 2374 Ca(2+)-ATPase inhibitor.
SGTC_209 4077-0173 175.592 µM -1.40700205693152 0.09615476404896 no 3027 0.0797133894198671 4410 15993494
SGTC_1676 st018489 23.4 µM -1.40783988686485 0.0960225816409086 no 3028 0.0795892432406705 4434 3696235
SGTC_1604 st002052 72.4 µM -1.40789791756498 0.0960134312275344 no 3029 0.0795806499114759 4491 6254834 YHR062C RPP1
SGTC_133 0724-0033 378.92 µM -1.40886430569627 0.0958611431764502 no 3030 0.0794376479462493 4296 280309
SGTC_2138 5575593 77.673 µM -1.4123136076899 0.0953190344869248 no 3031 0.0789288207186536 4451 762213
SGTC_78 0336-0123 156.75 µM -1.41399072750656 0.0950562673371602 no 3032 0.0786823125169536 4289 6765896
SGTC_2440 5628896 157.78 µM -1.41483706091134 0.0949238685638438 no 3033 0.0785581375565584 4412 5522048
SGTC_3281 9140613 49.47 µM -1.41828847409301 0.094385342772742 no 3034 0.0780532801766663 4430 16013766
SGTC_519 k048-0011 62.8 µM -1.42184003795347 0.093833545870104 no 3035 0.0775363467668947 4468 6836379
SGTC_1017 4239-0030 168 µM -1.4250609293129 0.0933351868704379 no 3036 0.0770697946697688 4464 1149593
SGTC_2959 9079155 11 µM -1.42531355444544 0.0932961817874019 no 3037 0.0770332918747792 4462 16189457
SGTC_1938 st074717 56.4 µM -1.42818656399665 0.092853438805432 no 3038 0.0766190834284475 4320 17250979
SGTC_928 2764-0428 58.7 µM -1.42854597841115 0.0927981610292274 no 3039 0.0765673852550181 4475 662578
SGTC_1164 k060-0068 93.7 µM -1.42927019746425 0.0926868503878266 no 3040 0.0764632941803554 4460 5963676
SGTC_2692 st077426 47.7 µM -1.42930439669217 0.0926815964955251 no 3041 0.0764583814324195 4443 25238571
SGTC_1600 coumarin 106 71.1 µM -1.43030459054027 0.0925280380722106 no 3042 0.0763148089267417 4512 100336 A hepatotoxic, DNA x-linker.
SGTC_128 0906-2981 13.371 µM -1.43350185464637 0.0920384289777123 no 3043 0.0758572346381402 4443 6740226
SGTC_1791 st048313 56.1 µM -1.43645792344991 0.0915874641422684 no 3044 0.0754360405395827 4478 1204976
SGTC_1010 4112-3296 15.2 µM -1.43846278816462 0.0912825439886153 no 3045 0.0751513942353909 4491 704384
SGTC_2250 alverine citrate 130 µM -1.43907489145417 0.0911895992569488 no 3046 0.0750646525439499 4327 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2827 7993847 71.43 µM -1.43913708338039 0.0911801596620627 no 3047 0.0750558435465292 4499 2985692
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.43952603852059 0.091121139834844 no 3048 0.0750007689912116 4461 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2803 7707263 71.43 µM -1.43990238643637 0.0910640599946808 no 3049 0.0749475089161462 4434 2199229
SGTC_8 0354-0001 70 µM -1.44719449282753 0.0899633120541767 no 3050 0.0739212292730964 4466 4993152
SGTC_2182 6325192 200 µM -1.4495272501402 0.0896132767711826 no 3051 0.0735951979853086 4492 736248
SGTC_2687 chenodiol 100 µM -1.45611399153121 0.0886303897930211 no 3052 0.0726805551695335 4507 5702181 A cholesterol synthesis inhibitor.
SGTC_620 0109-0052 432 µM -1.45751408688478 0.0884225034380365 no 3053 0.072487262858312 4513 493037
SGTC_190 3970-0790 3.722 µM -1.4596245550449 0.0881098277437048 no 3054 0.0721966434538493 4436 2832352
SGTC_1227 3909-8010 46.6 µM -1.46711121914627 0.0870072912861102 no 3055 0.0711729013286493 4459 15982272
SGTC_888 0916-0002 6.97 µM -1.46785494145753 0.086898330961853 no 3056 0.0710718148954119 4491 2802138 YIL048W NEO1
SGTC_986 1493-0483 84 µM -1.47364133561167 0.0860540649905381 no 3057 0.0702890928461482 4438 40079
SGTC_254 nsc-64875 3.808 µM -1.48857617338468 0.0839033717464284 no 3058 0.0682995048534843 4482 56993
SGTC_778 3456-2434 196 µM -1.48882384327397 0.083868049416343 no 3059 0.068266880978546 4418 5539063
SGTC_798 1287-0182 476 µM -1.48906988917046 0.0838329697574061 no 3060 0.0682344829305392 4522 1649755
SGTC_520 3584-0023 682 µM -1.49208598661721 0.0834038488968673 no 3061 0.0678383025262204 4489 1340790
SGTC_1498 4478-3555 97.6 µM -1.49360410179698 0.0831884818804555 no 3062 0.0676395633579368 4492 3437919
SGTC_788 1182-0090 188 µM -1.49776789516541 0.0825999329074956 no 3063 0.0670967823910938 4496 5715185
SGTC_627 1391-0720 175 µM -1.50984903870666 0.0809100138164269 no 3064 0.0655409743714194 4479 997839
SGTC_2446 5162541 200 µM -1.51910852877523 0.079632557578834 no 3065 0.0643675901459672 4483 1549321
SGTC_3028 9087778 49.47 µM -1.51969663805127 0.0795519392808538 no 3066 0.0642936184779952 4483 17217395
SGTC_1114 scopoletin 1.73284 µM -1.52438455417281 0.0789115242764411 no 3067 0.0637063381165704 4534 5280460 A coumarin with genotoxic properties.
SGTC_890 0929-0006 47.2 µM -1.52664951093024 0.0786035118803354 no 3068 0.063424094217268 4508 1378169
SGTC_566 0958-0068 16.5 µM -1.52737758831125 0.0785046941254765 no 3069 0.0633335730567736 4422 6815365
SGTC_1546 5-methoxyflavanone 78.7 µM -1.52865179388749 0.078331980201884 no 3070 0.0631753943744338 4540 147795
SGTC_2546 rhodinyl acetate 100 µM -1.53259168410056 0.0777997651830668 no 3071 0.0626882458677009 4468 6708682
SGTC_1660 st012960 28.1 µM -1.53677910384995 0.0772371263539648 no 3072 0.0621737061035153 4527 24207266
SGTC_1508 1080-0625 72.9 µM -1.53854250339076 0.0770011159127226 no 3073 0.0619580122511064 4447 767111
SGTC_508 roscovitine 141 µM -1.5425630920866 0.0764650570987326 no 3074 0.0614684094055851 4577 160355 A CDKinase inhibitor.
SGTC_3087 9117406 49.47 µM -1.54397132819469 0.0762779720404088 no 3075 0.0612976393490301 4518 42546093
SGTC_3045 9092950 49.47 µM -1.54430256547788 0.0762340176030308 no 3076 0.0612575256858467 4496 44120432
SGTC_3255 9139072 49.47 µM -1.54584414493344 0.0760297070843919 no 3077 0.0610711063634168 4515 17646060
SGTC_83 0170-0301 39.027 µM -1.54733010234438 0.0758331631804524 no 3078 0.0608918332719231 4546 3089716
SGTC_1982 st072467 71.9 µM -1.54874518919962 0.0756463530897021 no 3079 0.0607214930918354 4509 3163533
SGTC_1927 st060202 13.8 µM -1.5563591596978 0.0746472219649424 no 3080 0.059811355481035 4455 688887
SGTC_2246 7293507 91.5585 µM -1.5583634559472 0.0743858933325789 no 3081 0.059573557174191 4559 887656
SGTC_1855 st056195 39.6 µM -1.56389275438744 0.0736685816174716 no 3082 0.0589213781903968 4448 4028379
SGTC_2073 5212005 126 µM -1.5664300612931 0.0733411940257729 no 3083 0.0586239849622603 4444 691789
SGTC_2847 9005661 71.43 µM -1.56741264043116 0.0732147116287263 no 3084 0.0585091356255803 4572 2991449
SGTC_70 0141-0289 43.283 µM -1.57054772078798 0.072812264341793 no 3085 0.0581438707610271 4480 352408
SGTC_1531 st059297 52.4 µM -1.57450738782008 0.0723063887788561 no 3086 0.0576850974591432 4563 7566702
SGTC_1824 st053723 68.6 µM -1.57838290460345 0.0718138763318172 no 3087 0.0572388350933888 4553 675225
SGTC_623 k072-0108 16.9 µM -1.57859334973574 0.0717872061573011 no 3088 0.0572146805124096 4506 5382803
SGTC_188 3229-0966 278.469 µM -1.57945390215221 0.0716782254996112 no 3089 0.0571159910442675 4587 5722370
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.57983918147125 0.0716294747434717 no 3090 0.0570718500708855 4515 6708760
SGTC_2171 5739187 198.077 µM -1.57984257934336 0.0716290449118757 no 3091 0.0570714609003945 4503 2262761
SGTC_1560 lithocholic acid 53.1 µM -1.58115936718069 0.0714626198821194 no 3092 0.0569208016743739 4477 9903 A bile acid which acts as a detergent.
SGTC_650 1328-0195 38 µM -1.5845396819576 0.0710367503355197 no 3093 0.0565354794278242 4551 2780821
SGTC_2594 a-mangostin 100 µM -1.58838554156221 0.0705546023066056 no 3094 0.0560995924373608 4537 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1667 st014849 34.6 µM -1.59071538239839 0.0702637405121751 no 3095 0.0558368217580405 4627 5348460
SGTC_749 1000-0129 128 µM -1.59088786068942 0.0702422447062135 no 3096 0.0558174074960796 4554 708470
SGTC_1054 3429-0080 167 µM -1.59346047867674 0.0699222217642319 no 3097 0.0555284637761838 4552 1162877
SGTC_392 N-ethylmaleimide 8.33 µM -1.59416331677901 0.0698349870608265 no 3098 0.0554497301853514 4505 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_46 0329-0187a 2.197 µM -1.59445082213815 0.069799326683602 no 3099 0.0554175485661664 4528 46494817
SGTC_2648 atorvastatin 78.68 µM -1.59720072568819 0.0694589535072793 no 3100 0.0551104855100195 4532 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2102 5377816 72.7585 µM -1.60076502897151 0.0690196807852848 no 3101 0.0547144859694202 4578 1379702
SGTC_1194 1488-0194 225 µM -1.60097848407119 0.0689934422076955 no 3102 0.0546908423618841 4533 1391452
SGTC_802 4112-3352 742 µM -1.60422213134494 0.068595668246719 no 3103 0.0543325490497358 4574 704594
SGTC_2190 6049624 200 µM -1.60532923462294 0.0684603079413858 no 3104 0.0542106843665875 4467 2265554
SGTC_2595 hexamethylquercetagetin 100 µM -1.60959939657814 0.0679401449074872 no 3105 0.0537426700242955 4529 386331
SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.6108574060076 0.0677874859094492 no 3106 0.0536054027747166 4554 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.61134002555569 0.0677289905666485 no 3107 0.0535528156872359 4561 140250 A respiratory chain inhibitor.
SGTC_282 k297-0036 65.7 µM -1.61450699181373 0.0673461090579475 no 3108 0.0532087507516186 4547 5061378
SGTC_448 monastrol 171 µM -1.62256683440662 0.0663792336727772 no 3109 0.0523410175577521 4485 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2938 9059746 27.26 µM -1.62362195932863 0.0662534583829888 no 3110 0.0522282579395364 4535 6471769
SGTC_1496 4469-0713 57.4 µM -1.62662673708271 0.0658962875167474 no 3111 0.051908198605938 4557 746691
SGTC_2490 carminic acid 95.39 µM -1.63367414294164 0.0650644340058518 no 3112 0.0511636452376939 4547 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_916 4466-0038 42 nM -1.63424509091501 0.0649973996144063 no 3113 0.0511036990333862 4596 5722064 YGL116W CDC20
SGTC_1369 1866-0067 208 µM -1.64743120338492 0.0634641016425463 no 3114 0.049734723047463 4574 3531355
SGTC_395 anisomycin 6.25 µM -1.65514336270023 0.0625804575499818 no 3115 0.0489477103402655 4577 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1386 3228-0095 33.8 µM -1.65915691440944 0.0621244025837406 no 3116 0.048542088543965 4562 870181
SGTC_2164 5685496 200 µM -1.66033428451124 0.0619911124980461 no 3117 0.0484236111299307 4507 759046
SGTC_585 0kpi-0023 191 µM -1.66160943477549 0.0618470045607128 no 3118 0.0482955551986443 4504 64601
SGTC_640 3381-0960 37.1 µM -1.6622497000903 0.061774745243079 no 3119 0.0482313593081161 4621 1745025
SGTC_1000 4048-0884 8.67 µM -1.66585597398945 0.0613689772748743 no 3120 0.0478710521586763 4568 13040088
SGTC_1383 3049-0032 20.7 µM -1.669133376103 0.0610020217879471 no 3121 0.0475454750368391 4607 712864
SGTC_3186 9110464 49.47 µM -1.67032116598484 0.060869454736486 no 3122 0.0474279188260118 4572 17018021
SGTC_318 1488-0629 67.2 µM -1.67639419957499 0.0601951716031028 no 3123 0.0468305021660767 4619 3662576
SGTC_1796 st049173 110.4 µM -1.6774127609624 0.0600826564928191 no 3124 0.0467308978587131 4564 94134
SGTC_3155 9099265 49.47 µM -1.67821265798122 0.0599944115761076 no 3125 0.0466527957728517 4563 25236499
SGTC_3061 glucosamine 200 µM -1.67951540376717 0.0598509095097725 no 3126 0.0465258196782361 4510 91431 and experimental redox chemotherapeutic
SGTC_1430 4049-0248 69.1 µM -1.690944605826 0.0586034421115917 no 3127 0.0454236914526542 4603 22774488
SGTC_616 4092-0450 108 µM -1.69218542010734 0.058469247965672 no 3128 0.045305312775902 4593 787165
SGTC_1086 cerivastatin 2.18 µM -1.69948599021093 0.0576845712161854 no 3129 0.0446138260300774 4608 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_109 0132-0036 33.701 µM -1.70104161817816 0.0575184449986202 no 3130 0.0444675862306643 4513 67274 A color developer.
SGTC_293 4049-0273 38.5 µM -1.70237147953422 0.0573767270718708 no 3131 0.0443428764866229 4482 1380311
SGTC_1606 st000094 49.2 µM -1.70715014856186 0.0568697499096715 no 3132 0.0438970740420151 4607 1242210
SGTC_32 0928-0142 34.1 µM -1.70868395289584 0.0567077759760723 no 3133 0.0437547540838232 4605 2244242
SGTC_3162 9099653 49.47 µM -1.70886144465879 0.0566890558438746 no 3134 0.0437383088844498 4567 25237511
SGTC_1178 0988-0033 191 µM -1.71254041498108 0.0563021284548891 no 3135 0.0433985616524314 4642 5392207
SGTC_480 am 92016 50 µM -1.71960798790798 0.0555646564752671 no 3136 0.0427518615994476 4602 2129 K+ channel blocker.
SGTC_2221 6807166 181.081 µM -1.73295916198433 0.0541923429870838 no 3137 0.0415514637906991 4599 674925
SGTC_988 1497-1057 103 µM -1.73718211764762 0.0537639101654252 no 3138 0.0411775151535625 4599 3533044
SGTC_3307 9126885 69.2785 µM -1.73753276584319 0.0537284566999764 no 3139 0.04114658784809 4577 24824909
SGTC_351 caspofungin 25 nM -1.73878772088701 0.053601721948191 no 3140 0.0410360546276889 4599 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_80 0159-0065 512.242 µM -1.73881564251091 0.0535989049090854 no 3141 0.0410335981038881 4586 1548079
SGTC_186 3455-3465 67.277 µM -1.75384116072891 0.0520999015583996 no 3142 0.0397288639917444 4629 755278
SGTC_1338 1486-1223 76 µM -1.75423959846895 0.0520606098294514 no 3143 0.0396947303348183 4610 3444526
SGTC_1801 st050089 28.441 µM -1.75549893451598 0.0519365758319352 no 3144 0.039587001374373 4640 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2054 5233173 129 µM -1.7572323706589 0.0517662311452789 no 3145 0.0394391049043091 4590 6889
SGTC_2899 9053889 58.44 µM -1.75768447969423 0.0517218755069845 no 3146 0.0394006050365746 4615 6470052
SGTC_941 3237-0776 460 µM -1.75834858179826 0.0516567763811781 no 3147 0.039344108103613 4604 760008
SGTC_21 0849-0113 22.993 µM -1.76338587460092 0.0511651103783426 no 3148 0.0389177152706406 4613 1560156
SGTC_2523 spermine 47.74 µM -1.76511604071959 0.0509970988626828 no 3149 0.0387721326573055 4605 1103 A DNA binding polyamine.
SGTC_1740 st038286 13.222 µM -1.76742063335172 0.0507739887821516 no 3150 0.0385789049692899 4606 716786
SGTC_3003 9075612 71.4286 µM -1.77228644352974 0.0503054776480621 no 3151 0.0381735102089155 4624 6501993
SGTC_1634 st006576 41 µM -1.77501227942339 0.0500445263971035 no 3152 0.0379479298368882 4587 3915356
SGTC_2368 9071271 200 µM -1.77829445916139 0.04973174843292 no 3153 0.037677752952358 4610 27209959
SGTC_1204 4049-0315 18.3 µM -1.77875135641911 0.0496883319744136 no 3154 0.0376402676782472 4615 588402
SGTC_607 4491-0986 66.8 µM -1.77926777185835 0.0496392962410098 no 3155 0.0375979360071095 4613 698981 YDR232W HEM1
SGTC_2789 5281112 71.43 µM -1.78017077144347 0.0495536455806429 no 3156 0.0375240086247844 4626 765948
SGTC_718 1130-0073 349 µM -1.78287767384064 0.0492975989936027 no 3157 0.0373031090720263 4623 6740020
SGTC_1232 0279-0259 161 µM -1.78558463834393 0.0490426040349537 no 3158 0.0370832679966035 4613 1560000
SGTC_1144 3486-0183 12.5 µM -1.78739193459068 0.0488729448067485 no 3159 0.0369370821422284 4627 6744069
SGTC_3237 9133362 49.47 µM -1.78896251685931 0.0487258881868114 no 3160 0.0368104261740556 4610 43845137
SGTC_726 3448-4391 34.2 µM -1.78951077228126 0.0486746373417853 no 3161 0.0367662970980073 4675 1356692
SGTC_1360 1598-0022 39.8 µM -1.79869426718846 0.0478225549391806 no 3162 0.0360335281353411 4632 761525
SGTC_212 3807-4682 38.772 µM -1.79910350349406 0.0477848640454652 no 3163 0.0360011547826676 4687 3125501 YBL034C STU1
SGTC_1306 1185-0270 9.02 µM -1.80264725311175 0.0474594766082979 no 3164 0.0357218154647682 4635 1548076
SGTC_152 4469-0003 551.229 µM -1.8049662453638 0.0472475091284761 no 3165 0.0355399821210593 4616 697280
SGTC_2840 9008771 71.43 µM -1.80873219448541 0.046904899894668 no 3166 0.0352463094003213 4588 2992978
SGTC_33 0986-0033 35.816 µM -1.81169185290233 0.0466370440631067 no 3167 0.0350169115913743 4624 2848082
SGTC_1897 st060201 15 µM -1.81187494580544 0.046620514134822 no 3168 0.035002760728281 4618 611878
SGTC_2834 9001755 58.44 µM -1.81677715976733 0.0461796796445617 no 3169 0.0346256207326558 4488 2989575
SGTC_3345 9148410 3.559 µM -1.8169751412977 0.0461619466114868 no 3170 0.034610459893337 4572 4903596
SGTC_1854 st056233 32.9 µM -1.82551534269239 0.0454022001045606 no 3171 0.0339616490204608 4572 5393174
SGTC_1233 0325-0408 14.2 µM -1.83004480337391 0.0450033540223956 no 3172 0.0336216197761402 4652 12874
SGTC_3114 9122766 49.47 µM -1.83954157568662 0.0441762617195545 no 3173 0.03291778432215 4624 17176985
SGTC_2038 4100038 30.985 µM -1.84103000705184 0.0440477491912977 no 3174 0.0328085807407459 4610 3596803
SGTC_2585 alliin 100 µM -1.84331153617043 0.0438513452342526 no 3175 0.0326417688836249 4634 87310 A garlic compound which reacts with lipids.
SGTC_1607 st000305 50.6 µM -1.84997895100331 0.0432814310833091 no 3176 0.0321582917184496 4641 5457690
SGTC_1263 0774-1208 64.8 µM -1.85351065740337 0.0429819814871874 no 3177 0.031904600018068 4620 906585
SGTC_1226 3909-7979 35.4 µM -1.86207081976414 0.0422631172907636 no 3178 0.0312965542391321 4625 6615510
SGTC_2751 anetholtrithion 17.25 µM -1.86307126133932 0.0421797409497332 no 3179 0.0312261204655924 4592 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_716 1683-5115 658 µM -1.866906374852 0.0418613566869236 no 3180 0.0309573317432483 4638 723597
SGTC_2891 9063876 19.48 µM -1.87181582241091 0.0414566261108091 no 3181 0.0306160442487564 4675 6472478
SGTC_950 1165-0508 94.1 µM -1.87558820029996 0.0411477937671242 no 3182 0.0303559239625507 4635 6148369
SGTC_1336 1486-0901 104 µM -1.88472613515943 0.0404074289110903 no 3183 0.0297334109744932 4656 5006114
SGTC_1139 k015-0024 46.9 µM -1.88732088061888 0.0401991831523001 no 3184 0.0295585898072561 4669 2766652
SGTC_1125 tnp00248 1.32998 µM -1.89178927663353 0.0398426083009912 no 3185 0.0292595313099426 4649 24207736
SGTC_2985 9022375 71.43 µM -1.89549663673454 0.0395487188738935 no 3186 0.02901331844578 4645 4939335
SGTC_3180 9109287 49.47 µM -1.9040159731521 0.0388800535794636 no 3187 0.0284540519594084 4676 18891271
SGTC_937 3122-0005 46.7 µM -1.90632404999301 0.0387004911088353 no 3188 0.0283040879115594 4630 759535
SGTC_2308 7584454 197.62 µM -1.90794502010003 0.0385747880928037 no 3189 0.0281991613419325 4627 893577
SGTC_1645 Cervolide 78 µM -1.90848357680656 0.0385330977980539 no 3190 0.0281643719194136 4686 23173 A fragrance.
SGTC_2684 capsaicin 100 µM -1.9092057395902 0.0384772519852706 no 3191 0.028117778089119 4677 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2418 pentamidine 31.67 µM -1.91077321006024 0.0383562643749984 no 3192 0.0280168659453762 4605 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2608 thymoquinone 42.66 µM -1.91760517531497 0.0378325455584298 no 3193 0.027580546710677 4618 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_766 1391-0721 126 µM -1.91901450531683 0.037725239759536 no 3194 0.027491249070539 4670 1020919 YIL115C NUP159
SGTC_1426 4048-4480 71.7 µM -1.92443901207207 0.0373145361472861 no 3195 0.0271497892027563 4683 14224343
SGTC_544 k015-0020 52.4 µM -1.93055627098737 0.0368557722064322 no 3196 0.0267689750352282 4687 3008304
SGTC_1826 st055655 41.6 µM -1.93059817372073 0.0368526456864235 no 3197 0.0267663819501383 4668 676168
SGTC_685 1278-0033 54.9 µM -1.9393212216834 0.0362064926349336 no 3198 0.0262311181853331 4692 3590572
SGTC_3048 9093155 49.47 µM -1.95277191946506 0.0352283462432926 no 3199 0.0254233136539595 4681 25236002
SGTC_1876 myriocin 605 nM -1.95412941482286 0.0351308438682902 no 3200 0.0253429571077002 4645 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1623 st003709 20.3 µM -1.96009037351088 0.0347053143121275 no 3201 0.0249926141026441 4661 16192618
SGTC_472 calcifediol 10 µM -1.97331221282487 0.0337765553391639 no 3202 0.0242300011721198 4711 5283731 A vitamin D metabolite.
SGTC_129 0088-0017 176.636 µM -1.97667294396191 0.0335437709644341 no 3203 0.0240393054997284 4550 182446
SGTC_3339 9145883 14.936 µM -1.98944489658133 0.0326711246162126 no 3204 0.0233260591290057 4628 2030670
SGTC_95 0471-0001 561.058 µM -2.00287138273002 0.0317740289663405 no 3205 0.0225955477273836 4667 4015405
SGTC_883 0850-0245 24.6 µM -2.00313929216316 0.0317563376944544 no 3206 0.0225811697847277 4703 6823229 YPR165W RHO1
SGTC_730 1436-0052 41.2 µM -2.004089132401 0.0316936810084928 no 3207 0.0225302566762654 4698 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3139 9095020 49.47 µM -2.00544749638598 0.0316042533824449 no 3208 0.0224576141868647 4605 25236292
SGTC_2162 5663267 200 µM -2.00760558663658 0.0314626048526725 no 3209 0.0223426102180156 4689 6456493
SGTC_2910 7948405 25.97 µM -2.0110630309136 0.031236766087665 no 3210 0.0221593997218058 4673 2971328
SGTC_96 0929-0093 37.281 µM -2.01346652589583 0.0310805621556929 no 3211 0.0220327865393423 4704 6991579
SGTC_2933 9026794 32.47 µM -2.02406788770704 0.0303992688456467 no 3212 0.0214815835762313 4640 17586027
SGTC_3126 9127922 49.47 µM -2.02647905475401 0.0302460554940489 no 3213 0.0213578584894001 4636 45595682
SGTC_3208 9114115 49.47 µM -2.02798353011374 0.030150780926096 no 3214 0.021280964483885 4634 650895
SGTC_2159 5658611 73.75 µM -2.02996495303164 0.030025682219161 no 3215 0.021180050929704 4675 793844
SGTC_2717 st081029 62.2815 µM -2.03273159722873 0.0298517282566716 no 3216 0.0210398235928896 4679 5292846
SGTC_960 1222-0186 7.7 µM -2.0356190286726 0.0296710721080282 no 3217 0.0208943127555745 4672 3126296
SGTC_1998 st075797 76.8 µM -2.03789491311424 0.0295293184360761 no 3218 0.0207802217198819 4689 24208315
SGTC_359 0081-0058 15.9 µM -2.04131957703613 0.0293170726800232 no 3219 0.0206095362040118 4663 3494159
SGTC_127 0180-0333 59.125 µM -2.04405709122788 0.0291483259494205 no 3220 0.0204739537190055 4627 771601
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -2.04812605663761 0.0288989971294614 no 3221 0.0202738246811893 4702 5393153
SGTC_2742 clothiapine 36.27 µM -2.04866796054043 0.0288659257322153 no 3222 0.0202472970987582 4718 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2931 9014674 55.67 µM -2.05878212010129 0.028254428103372 no 3223 0.0197575576222498 4655 2996810
SGTC_1743 st037606 46.3785 µM -2.06043929527586 0.0281552714789633 no 3224 0.0196782817808622 4660 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_271 rotenone 740 µM -2.06355386330723 0.0279696960394157 no 3225 0.0195300179122188 4716 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_528 3492-0019 172 µM -2.06746051980625 0.0277383669602077 no 3226 0.0193453903282489 4696 2869262
SGTC_2075 5212009 200 µM -2.07090289605987 0.0275358532530357 no 3227 0.0191839357425347 4663 780898
SGTC_2339 9000433 200 µM -2.07502289232212 0.0272950973282076 no 3228 0.0189922065820774 4657 2988954
SGTC_3235 9132602 49.47 µM -2.08947558216334 0.026464381433726 no 3229 0.0183324668710782 4689 4912240
SGTC_3175 9106517 49.47 µM -2.09654808174674 0.0260656289373797 no 3230 0.0180167996715212 4708 41468073
SGTC_3164 9100705 49.47 µM -2.1039008417384 0.0256564154350602 no 3231 0.0176935487765594 4720 17174235
SGTC_545 4218-0007 221 µM -2.10849494399457 0.0254034736859785 no 3232 0.0174940998197157 4704 2840508
SGTC_63 0099-0242 26.702 µM -2.11489736641797 0.0250544562031198 no 3233 0.0172193478532683 4703 3898502 YLR359W ADE13
SGTC_1295 1013-0063 9.78 µM -2.11635116217681 0.0249757674161722 no 3234 0.017157476211881 4721 6826038
SGTC_475 α-linolenic acid 10 µM -2.11898346194304 0.0248338176383028 no 3235 0.017045932312546 4706 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1958 st076513 41.9 µM -2.1338631532836 0.0240440779525807 no 3236 0.0164269922257108 4660 732122 YGL099W LSG1
SGTC_1171 0368-0077 21.4 µM -2.13426680640382 0.0240229514902391 no 3237 0.0164104733994225 4709 3239779
SGTC_871 0574-0004 149 µM -2.13647380479467 0.0239077168413657 no 3238 0.0163204069526503 4682 9551173
SGTC_2254 7938975 95.19 µM -2.1435333342905 0.0235422308505019 no 3239 0.0160351486925395 4714 2969277
SGTC_3317 9138495 8.753 µM -2.14826559879817 0.0232998724945553 no 3240 0.0158463310506758 4665 17020139
SGTC_929 2805-0021 398 µM -2.15394798351794 0.0230116326377737 no 3241 0.0156221256941607 4716 3098024
SGTC_159 3970-0959 50 µM -2.16472175724761 0.0224733729784689 no 3242 0.0152044999254285 4712 6615653
SGTC_2563 tomatine 8.54 µM -2.16657575848541 0.0223818258856895 no 3243 0.0151336087374468 4655 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -2.17312467395009 0.0220609667770434 no 3244 0.0148854675595127 4727 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2828 7998861 71.43 µM -2.18401302172289 0.0215360965037202 no 3245 0.0144806456080589 4730 2988188
SGTC_2551 apiole 73.87 µM -2.19208720151809 0.021153731841555 no 3246 0.0141866053532215 4695 10659 A possible DNA adduct former.
SGTC_2377 9073351 62.6 µM -2.19596338442695 0.0209722194628342 no 3247 0.014047282137995 4702 7337946 YHR072W ERG7
SGTC_3178 9107506 49.47 µM -2.19759711310245 0.020896111661636 no 3248 0.013988914571113 4701 8897194
SGTC_1955 wogonin 32.4 µM -2.20153467754495 0.02071363915387 no 3249 0.0138490972765207 4692 5281703 A flavanone.
SGTC_2294 7971431 200 µM -2.20226601620239 0.0206798968642798 no 3250 0.0138232616189037 4714 5741572
SGTC_2506 ethyl hematommate 54.16 µM -2.20257368284039 0.0206657157482962 no 3251 0.0138124052517981 4722 3940691 An allergen.
SGTC_1119 parthenolide 318.541 nM -2.20312233246514 0.0206404475699503 no 3252 0.013793063774472 4728 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1919 st067113 52.3 µM -2.20472887730468 0.0205666082503631 no 3253 0.0137365627406811 4684 1268243
SGTC_3015 9080845 49.47 µM -2.21262487335537 0.0202069406360771 no 3254 0.0134617593627131 4737 5296973
SGTC_1009 4106-0057 9.87 µM -2.21771942320947 0.0199777226457978 no 3255 0.0132869845326798 4713 2928005
SGTC_236 1509-0011 5.31 µM -2.22727663220455 0.0195536653253324 no 3256 0.0129643956396672 4729 3107280
SGTC_2123 5259487 200 µM -2.23195077488433 0.0193490708869021 no 3257 0.0128091082558743 4726 2173474
SGTC_1196 1588-0294 184 µM -2.24930514129653 0.0186052846240922 no 3258 0.0122465444759931 4757 6144269
SGTC_3252 9135871 49.47 µM -2.25376155520873 0.0184182638616091 no 3259 0.0121055862902988 4737 17682838
SGTC_1472 k841-0093 193 µM -2.25694590409622 0.0182856103297908 no 3260 0.0120057276002955 4749 X1472
SGTC_2917 7979103 53.79 µM -2.26296763725368 0.0180369814958513 no 3261 0.0118188421681616 4718 2980565
SGTC_104 0074-0074 590.992 µM -2.26531577244666 0.0179408143881247 no 3262 0.0117466544197309 4693 3943124
SGTC_378 3970-0959 8.33 µM -2.26782610406255 0.017838488507169 no 3263 0.0116699038518634 4723 6615653
SGTC_2139 5578692 56.4705 µM -2.26946329647737 0.0177720219879556 no 3264 0.011620083396325 4725 650991 YMR113W FOL3
SGTC_2621 lithochol-11-enic acid 100 µM -2.27057842307781 0.0177268712908929 no 3265 0.0115862554406876 4688 6708711
SGTC_1203 3992-3522 103 µM -2.275534427909 0.0175273883750187 no 3266 0.0114369449165447 4711 5322312
SGTC_382 3229-0966 23.2 µM -2.27785375573574 0.0174346939142366 no 3267 0.011367646150268 4753 5722370
SGTC_934 2950-0684 338 µM -2.29082359951993 0.0169240199730243 no 3268 0.0109868090719664 4735 1121253
SGTC_1810 st050138 53 µM -2.29128183310396 0.0169062139231804 no 3269 0.0109735593139094 4760 3444541
SGTC_3342 9147791 14.508 µM -2.29494433968288 0.0167644710111184 no 3270 0.0108681571587872 4714 1838168
SGTC_2145 5634607 200 µM -2.30089791921264 0.0165362305303462 no 3271 0.0106987008803572 4751 308662
SGTC_2479 5617353 43.85 µM -2.30173153550482 0.0165044857022934 no 3272 0.0106751583151263 4726 2731746
SGTC_1830 st055982 50.3 µM -2.30397919919846 0.0164191525593691 no 3273 0.010611905631949 4726 455313 An antimicrobial agent.
SGTC_1088 bifonazole 369 nM -2.31664745211791 0.0159452310440491 no 3274 0.0102614721134633 4743 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1344 1488-0097 29.1 µM -2.3193658650209 0.0158450772396123 no 3275 0.0101876034368593 4754 747966
SGTC_3012 9080433 71.4286 µM -2.322748476214 0.0157212062291704 no 3276 0.0100963342172286 4741 17688859
SGTC_2989 9073649 71.4286 µM -2.32641419076428 0.0155879067949501 no 3277 0.00999823265359052 4701 21367202
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -2.34891678471054 0.0147906953601626 no 3278 0.00941405708856357 4710 6728940
SGTC_740 k014-0057 261 µM -2.35114123651473 0.0147138274085214 no 3279 0.00935796414575417 4742 4012779
SGTC_1208 2323-2347 50.3 µM -2.35469315466806 0.0145918001326412 no 3280 0.00926900321899743 4748 5412760
SGTC_1043 0916-0009 19.3 µM -2.3626403873877 0.0143219208776096 no 3281 0.00907263372290493 4749 3101130
SGTC_958 1222-0007 33 µM -2.37037543805367 0.014063386245388 no 3282 0.008885015269401 4749 7312461
SGTC_564 3555-0129 330 µM -2.38356716253366 0.0136317442167072 no 3283 0.008572877743043 4743 563260
SGTC_666 0272-0154 136 µM -2.38787291521285 0.0134933542359999 no 3284 0.00847310028574661 4750 6870312
SGTC_174 3553-0389 74.3 µM -2.39629439811071 0.0132261846952468 no 3285 0.00828089105574143 4749 738071
SGTC_815 1582-0027 36.9 µM -2.39849489856248 0.0131571320660263 no 3286 0.00823130290215305 4750 3128206
SGTC_2158 5657123 3.6195 µM -2.40353377524918 0.0130001824743063 no 3287 0.0081187334885405 4760 2858827
SGTC_2243 6634756 200 µM -2.40573083601717 0.0129322573594474 no 3288 0.0080700757969079 4741 885676
SGTC_554 4483-2211 187 µM -2.41149973083973 0.0127553631557541 no 3289 0.0079435317890837 4764 747107
SGTC_1449 4112-4002 201 µM -2.42521427057979 0.0123432109772082 no 3290 0.00764967691613559 4771 2059539
SGTC_2306 7482397 179.52 µM -2.4295767476222 0.0122145505274437 no 3291 0.00755823205579643 4729 891448
SGTC_1624 st003710 6.25 µM -2.42971125217454 0.0122106021874752 no 3292 0.00755542797850854 4760 24207033
SGTC_2564 betulinic acid 100 µM -2.4298575154104 0.0122063099303302 no 3293 0.00755237980250848 4709 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3100 9120536 49.47 µM -2.43425305592958 0.012077926607999 no 3294 0.00746127916931811 4709 16421196
SGTC_1822 st052468 42 µM -2.45817728282381 0.0113994889706346 no 3295 0.00698221100344434 4776 2873678
SGTC_1084 voriconazole 435 nM -2.46658314686241 0.0111691060465812 no 3296 0.0068204527345512 4775 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3207 9114163 49.47 µM -2.47088922428981 0.0110526635531216 no 3297 0.0067388780573854 4719 849233
SGTC_1735 st034310 56.75 µM -2.47183828795113 0.0110271419876487 no 3298 0.00672101529683055 4746 871153
SGTC_1142 3253-1408 9.78 µM -2.47457107588057 0.0109539398566996 no 3299 0.00666981373959589 4753 256655
SGTC_1811 st050069 61.5 µM -2.49456251799103 0.0104311813565334 no 3300 0.00630562542203443 4777 3877702
SGTC_2435 5706476 10.6 µM -2.5257555477083 0.00965893220124572 no 3301 0.00577248912313117 4758 5725375
SGTC_3136 9095672 49.47 µM -2.54298542010777 0.00925417098241571 no 3302 0.00549549076078524 4709 17217380
SGTC_2678 equilin 100 µM -2.55298885973791 0.00902604798480581 no 3303 0.00534014561166218 4773 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1553 gossypol 38.6 µM -2.55738078053499 0.00892745851883818 no 3304 0.00527318509597952 4768 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2381 9035592 200 µM -2.57923444084708 0.00845078973891028 no 3305 0.00495097798624291 4764 4749657
SGTC_1275 0867-0008 21.1 µM -2.59210288517627 0.00818068097693454 no 3306 0.00476956195720873 4770 3422836
SGTC_1023 4482-3888 16 µM -2.6102963980063 0.00781175010815343 no 3307 0.00452319020698958 4760 3303168
SGTC_1239 0337-0584 35.4 µM -2.62140634058827 0.00759373080400701 no 3308 0.00437839099521724 4768 914301 YML130C ERO1
SGTC_831 k061-1017 217 µM -2.62908055685462 0.00744627950582442 no 3309 0.00428080384819249 4782 1240153
SGTC_1071 trifluoperazine 6.31 µM -2.63492685579123 0.00733564833606237 no 3310 0.00420777078691807 4782 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2122 5258151 111.688 µM -2.64485251682195 0.00715113767255023 no 3311 0.00408632646559337 4769 2173356
SGTC_2936 9038235 15.59 µM -2.64857872418211 0.0070829344730003 no 3312 0.00404155104439848 4738 4749415
SGTC_1013 4112-3890 241 µM -2.64971296585687 0.00706228797259099 no 3313 0.00402800906407655 4770 705171
SGTC_2121 5257820 149.641 µM -2.65463088908259 0.00697338056154091 no 3314 0.00396976156292143 4772 791256
SGTC_2078 5212016 200 µM -2.66629387949912 0.00676647331375445 no 3315 0.00383463095714679 4748 1899708
SGTC_2378 9074213 121.43 µM -2.67346117449254 0.00664202991221137 no 3316 0.00375364828770422 4771 657714
SGTC_99 0109-0120 622.8 µM -2.6812308933679 0.00650941625685408 no 3317 0.00366759425802279 4774 759414
SGTC_2859 9028643 45.46 µM -2.6869137096705 0.00641391017697152 no 3318 0.00360577901579383 4698 17151580
SGTC_281 1672-3440 14.9 µM -2.70497006448196 0.00611863050144592 no 3319 0.00341552725467048 4789 6833000
SGTC_3311 9131146 2.8755 µM -2.71570061905144 0.00594891450305212 no 3320 0.00330678465723213 4775 4900406 YPR165W RHO1
SGTC_65 0798-0905 34.986 µM -2.75335352813142 0.00538594099120504 no 3321 0.00294940796079954 4746 3602145
SGTC_2602 kawain 100 µM -2.78320885324111 0.00497375597054701 no 3322 0.00269120729980628 4765 5369129
SGTC_2519 cryptotanshinone 88.04 µM -2.81673472850527 0.00454459109956463 no 3323 0.00242572888004841 4775 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1878 temozolomide 1 mM -2.82336107238615 0.00446378970730563 no 3324 0.00237615086023477 4783 5394 DNA alkylating agent.
SGTC_1258 0671-0043 57.1 µM -2.84464272975163 0.00421288959563114 no 3325 0.00222306306364887 4769 4298767
SGTC_932 2857-0803 154 µM -2.93867354845261 0.00324880040798339 no 3326 0.00164810029203428 4772 674898
SGTC_2986 9022445 71.43 µM -2.95825771791766 0.00307494528273546 no 3327 0.0015469167159145 4781 6459286
SGTC_1750 st081859 2.357 µM -2.97882851288863 0.00290139559615368 no 3328 0.00144676334531268 4746 5291695
SGTC_2013 4024628 200 µM -2.98400458343687 0.00285914095784498 no 3329 0.00142251254977833 4779 5230760
SGTC_2643 anethole 100 µM -3.01879243895799 0.00258926037112415 no 3330 0.00126892168515844 4792 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_524 r073-0010 27.8 µM -3.03756227417927 0.00245341041001842 no 3331 0.00119250059632286 4775 2772106
SGTC_513 4245-1575 41.7 µM -3.0533241566724 0.00234434777928393 no 3332 0.00113160659100933 4709 719745
SGTC_904 1141-0088 396 µM -3.11943077669532 0.0019331517965641 no 3333 0.000906004161597922 4792 1378119
SGTC_2271 7849410 118.62 µM -3.1333841673542 0.00185521784262161 no 3334 0.000864015541914887 4772 972430
SGTC_1771 st048882 4.1505 µM -3.17341999263345 0.00164719772904608 no 3335 0.000753272087854705 4799 4580403
SGTC_2080 5212524 12.4 µM -3.18179041603652 0.00160648758985853 no 3336 0.000731838475621538 4784 260183
SGTC_2871 9038510 12.99 µM -3.22118674242001 0.0014269189496103 no 3337 0.000638304681989104 4784 4945164
SGTC_611 3453-1652 23.7 µM -3.28127727979158 0.00118808436305857 no 3338 0.000516690504216115 4791 1560575
SGTC_2124 5246320 200 µM -3.2854441168498 0.00117296376884486 no 3339 0.000509108691372689 4803 579342
SGTC_3315 9136395 68.55 µM -3.28629991003363 0.00116988016753656 no 3340 0.000507564326005046 4800 16876844
SGTC_2307 7538926 6.34 µM -3.38231868282146 0.000867483973454301 yes 3341 0.00035938354542185 4785 96582
SGTC_2326 6164455 177.58 µM -3.41073162049142 0.00079289387402056 yes 3342 0.000323944146634344 4784 2888790
SGTC_41 0478-0632 82.643 µM -3.43016144211876 0.000745336052998566 yes 3343 0.000301611113595307 4788 3750424
SGTC_2690 usnic acid 100 µM -3.45346133792926 0.00069177590504003 yes 3344 0.000276720814480803 4795 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2676 harmalol 100 µM -3.55305540813446 0.000500494090041437 yes 3345 0.000190392125897168 4808 5459187 A monoamine oxidase inhibitor
SGTC_1240 0356-0016 42.1 µM -3.76881410865972 0.000241543174128306 yes 3346 8.20124911432671e-05 4796 4305613
SGTC_895 0964-0006 13.7 µM -4.15178241471662 6.0410535023754e-05 yes 3347 1.6494791862965e-05 4794 6738897
SGTC_2022 5136654 200 µM -4.28128577006847 3.68015643111818e-05 yes 3348 9.29082768420102e-06 4804 1713771
SGTC_2879 9041815 71.43 µM -4.55042233304392 1.25749100650836e-05 yes 3349 2.6769173294234e-06 4808 4942971
SGTC_2783 7738165 71.43 µM -4.72116474304863 6.16988088880629e-06 yes 3350 1.17248951652615e-06 4806 17201110
SGTC_2921 7974240 10.71 µM -5.33108658549399 3.98573633574864e-07 yes 3351 4.8813427175283e-08 4809 2979074 YDR527W RBA50
SGTC_965 1291-5240 308 µM -5.54044882510664 1.44980023883108e-07 yes 3352 1.5084869845349e-08 4809 2834598