SGTCid condition conc unit NPR1|YNL183C.score NPR1|YNL183C.strain.pval NPR1|YNL183C.strain.significant NPR1|YNL183C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_221 trifluoperazine 10.304 µM 11.5457337434292 1.56449518356389e-31 yes 1 3.87883017333401e-31 41 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1754 st042065 16.137 µM 10.5440007969498 1.20525442394124e-26 yes 2 2.70726662362476e-26 19 1126236 YIL048W NEO1
SGTC_1760 st045453 10.4495 µM 8.97170974708724 7.52545264218264e-20 yes 3 1.45973443239878e-19 41 3323419 YIL048W NEO1
SGTC_1803 st050068 52.4 µM 8.11717349278057 1.32639971050364e-16 yes 4 2.38583199896476e-16 41 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2250 alverine citrate 130 µM 6.18358386114851 2.04304145369355e-10 yes 5 3.13312102263974e-10 49 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1801 st050089 28.441 µM 5.97727421891562 7.51778799248434e-10 yes 6 1.13451039958869e-09 49 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_3152 9099253 49.47 µM 5.7719358187172 2.63783626041179e-09 yes 7 3.91829834923891e-09 61 25236131
SGTC_2831 7999036 19.48 µM 5.24570164780363 5.45270097977772e-08 yes 8 7.78443360032882e-08 16 2988270
SGTC_2896 9052656 71.43 µM 5.22792196687896 6.01179070150744e-08 yes 9 8.57129141125557e-08 51 6469436
SGTC_2249 haloperidol 116.36 µM 5.19732631710408 7.10624411590254e-08 yes 10 1.01087642818763e-07 59 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1524 corynanthine 62.1 µM 4.96976732181126 2.39589076942949e-07 yes 11 3.35166469893614e-07 9 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_547 1120-0019 610 nM 4.93471386360907 2.87627705022878e-07 yes 12 4.0134174455581e-07 15 3676939
SGTC_2257 7960413 200 µM 4.88295021995392 3.75906561406907e-07 yes 13 5.22551310565718e-07 29 2974689 YIL048W NEO1
SGTC_172 1112-0046 2.638 µM 4.77138458822862 6.63423723679398e-07 yes 14 9.14819038393138e-07 23 2802135 YIL048W NEO1
SGTC_2015 5119600 184 µM 4.71855298253636 8.64553417880462e-07 yes 15 1.18764055005732e-06 18 2828786
SGTC_2021 4019055 173 µM 4.6276842781264 1.3547009751413e-06 yes 16 1.8488858025401e-06 82 44827708 YER133W GLC7
SGTC_1345 1488-0192 31.4 µM 4.48280178953624 2.72685638560855e-06 yes 17 3.68346751379895e-06 8 658348
SGTC_449 xestospongin c 11.1929 µM 4.29724156699723 6.4852611020432e-06 yes 18 8.64683500017576e-06 53 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_127 0180-0333 59.125 µM 4.24432951206407 8.25236025307855e-06 yes 19 1.09623991293706e-05 32 771601
SGTC_524 r073-0010 27.8 µM 4.24110172056623 8.37383325714162e-06 yes 20 1.11212649040044e-05 45 2772106
SGTC_751 0833-0568 350 µM 4.21904320924195 9.25074716833827e-06 yes 21 1.22670627619686e-05 13 6954252
SGTC_1656 st012921 11 µM 4.14202690596938 1.30496175961475e-05 yes 22 1.72124973106669e-05 26 6732821
SGTC_178 4092-0806 87.505 µM 4.13988140620454 1.31742188133763e-05 yes 23 1.73742707730545e-05 85 2169044
SGTC_1818 st052136 56.3 µM 4.08176057750193 1.70135838381627e-05 yes 24 2.2347914037331e-05 47 674169
SGTC_2688 kanamycin b 96.69 µM 4.01811483183646 2.2429013406074e-05 yes 25 2.93328038527373e-05 356 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1650 st011916 45.8 µM 3.99983831507209 2.42639650540672e-05 yes 26 3.16928871621234e-05 14 242528
SGTC_1800 st050079 29.0735 µM 3.98844294222024 2.54791461793025e-05 yes 27 3.32541973794836e-05 119 3645560
SGTC_146 3448-8650 53.125 µM 3.98222010308581 2.6166863681138e-05 yes 28 3.41372533808489e-05 135 2891488 YIL048W NEO1
SGTC_522 1273-0010 11.6 µM 3.93589466833446 3.1867909186165e-05 yes 29 4.14436620414462e-05 25 5705015
SGTC_1871 st057448 67.3 µM 3.85524811835338 4.46938350775517e-05 yes 30 5.78061561178889e-05 28 691747
SGTC_571 k831-0106 44.2 µM 3.8170337205059 5.23492675430888e-05 yes 31 6.75328582552469e-05 17 4783639
SGTC_3101 9120531 49.47 µM 3.7998086637324 5.61904179627819e-05 yes 32 7.24039242721161e-05 38 24824904
SGTC_1712 st032288 53.4 µM 3.79468905709265 5.73823738500403e-05 yes 33 7.39143016740768e-05 198 2883011
SGTC_1988 st071872 53.4 µM 3.78800271752134 5.89750350013981e-05 yes 34 7.59315944765093e-05 12 16414116
SGTC_2013 4024628 200 µM 3.68364287331846 8.99169744954197e-05 yes 35 0.000114962157403644 54 5230760
SGTC_445 e6 berbamine 66 µM 3.65915676571386 9.91213513008717e-05 yes 36 0.00012652325810373 130 6610268 A calcium/calmodulin antagonist.
SGTC_1451 4152-0210 104 µM 3.63476842825097 0.000109163487335537 yes 37 0.000139115218037495 36 659563
SGTC_2434 5670830 169.91 µM 3.54468157316689 0.00015515230696358 yes 38 0.000196543827942387 38 1549830
SGTC_1750 st081859 2.357 µM 3.53628508389097 0.000160257439475984 yes 39 0.00020289826428367 218 5291695
SGTC_2756 carbadox 75.1 µM 3.52729501370188 0.000165897523312017 yes 40 0.000209914350648175 69 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3037 9091026 49.47 µM 3.45782819270484 0.000216167835592346 yes 41 0.000272274266384946 154 25236398 YIL048W NEO1
SGTC_7 0192-1582 4.227 µM 3.41738615562173 0.000251650933484894 yes 42 0.000316127653872581 90 252616
SGTC_2036 5160441 105 µM 3.32513219117175 0.000353880295479867 yes 43 0.000441883110223129 104 134534 YIL048W NEO1
SGTC_46 0329-0187a 2.197 µM 3.27941193119825 0.000417771525894518 yes 44 0.00052011836279238 106 46494817
SGTC_1263 0774-1208 64.8 µM 3.27692325247769 0.000421539141698928 yes 45 0.000524724454981481 84 906585
SGTC_3181 9108277 49.47 µM 3.25694878467887 0.000452939838460112 yes 46 0.000563083751602565 40 17097298
SGTC_780 0109-0199 192 µM 3.21525841879062 0.000525581589349195 yes 47 0.000651635701830743 47 610414
SGTC_1424 4048-1941 275 µM 3.20540794298676 0.000544251651665746 yes 48 0.000674355905615159 55 X1424
SGTC_1747 st037496 66.6 µM 3.19242642922927 0.0005697933692399 yes 49 0.000705414399336833 43 723305
SGTC_2567 aureobasidin a 60 nM 3.17627309265599 0.000603122399405424 yes 50 0.000745902213402862 139 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_177 1327-0068 8.361 µM 3.10972886074488 0.000760301631754926 yes 51 0.00093629576419026 84 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_777 1315-0167 517 µM 3.10637496790079 0.000769143686918914 yes 52 0.000946981921214002 56 4221767
SGTC_3186 9110464 49.47 µM 3.03839684312089 0.000970061640407194 yes 53 0.00118920259323571 36 17018021
SGTC_367 0335-0881 7.1 µM 3.03461078512052 0.000982556844889356 yes 54 0.00120423140767813 139 23828853
SGTC_2148 5546263 113.568 µM 3.01540479389827 0.0010482490336981 no 55 0.00128318247207663 53 792097
SGTC_313 3474-0040 5.03 µM 2.98916532963981 0.00114451658341577 no 56 0.00139870359252403 137 1043375 YIL048W NEO1
SGTC_2167 5876490 200 µM 2.98316545347738 0.00116763709539277 no 57 0.00142641864226392 84 686534
SGTC_90 0870-0863 4.608 µM 2.92075198844337 0.00143481384275054 no 58 0.00174593840753413 102 1738164
SGTC_1444 4112-3581 28 µM 2.91237328369069 0.00147464898704289 no 59 0.00179346850949698 54 2877249
SGTC_1569 carminic acid 40.6 µM 2.90606185485857 0.00150531921017601 no 60 0.00183004544231852 60 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2958 9077254 16.72 µM 2.90280021047554 0.00152139611919513 no 61 0.00184921247413359 85 16457351
SGTC_2870 9038528 12.99 µM 2.87489178788011 0.00166549625684255 no 62 0.00202082995181707 72 6463316
SGTC_278 4092-0821 23.9 µM 2.87337946022699 0.00167364891796227 no 63 0.0020305300848587 95 877900
SGTC_1586 deoxycorticosterone acetate 53.7 µM 2.84389384261818 0.001840037199234 no 64 0.00222829467261818 57 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1019 4262-0212 3.4 µM 2.84342379549103 0.00184280740744016 no 65 0.00223158404490617 153 4677213
SGTC_1435 4092-0789 56.7 µM 2.83670439812 0.00188282467451637 no 66 0.00227908959152976 55 2248285
SGTC_163 TUB2.036 7.546 µM 2.83368562466129 0.00190105873158269 no 67 0.00230072875185758 210 15992207 YJR013W GPI14
SGTC_769 0302-0231 76 µM 2.81426733491199 0.00202223605351676 no 68 0.00244442765182437 134 571869 YER009W NTF2
SGTC_1886 st057356 49.9 µM 2.75736336353568 0.00241878957749535 no 69 0.00291347800849323 76 24207747
SGTC_345 1362-0200 395 µM 2.75082877071201 0.00246856692039577 no 70 0.00297223533939297 79 1419823
SGTC_540 1187-0821 17.3 µM 2.75055799851799 0.00247064938028222 no 71 0.00297469293209318 81 847520
SGTC_2259 7964009 200 µM 2.73108186194789 0.00262466995376478 no 72 0.00315633946479931 105 313134
SGTC_3342 9147791 14.508 µM 2.70722351572231 0.00282513878050259 no 73 0.00339242798293244 69 1838168
SGTC_1150 3909-7983 10.9 µM 2.64028169258299 0.00346343459358689 no 74 0.0041418571116783 104 23965914
SGTC_478 N-arachidonylglycine 10 µM 2.62979413056293 0.00357440720195057 no 75 0.00427182944032097 28 5283389
SGTC_2164 5685496 200 µM 2.61254682210775 0.00376386183180107 no 76 0.00449351905533377 85 759046
SGTC_2778 tioconazole 65.09 nM 2.58014441985188 0.00414429040166389 no 77 0.00493795020089627 168 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1885 st057546 99.9 µM 2.57959617721944 0.00415101301708564 no 78 0.00494579549682856 105 702008
SGTC_447 ml7 120 µM 2.55416483724519 0.00447377998803384 no 79 0.0053221425933807 112 4216 Selective myosin light chain kinase inhibitor.
SGTC_2753 fluvastatin 17.09 µM 2.55074048623459 0.00451891117580005 no 80 0.00537471672018875 115 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1454 4239-0054 42.6 µM 2.53613875768709 0.00471595011669774 no 81 0.00560411568473198 133 1340767
SGTC_674 0498-0004 451 µM 2.53324161252284 0.0047559438265932 no 82 0.00565065127033497 108 4231473
SGTC_1748 st037455 53.6035 µM 2.52371060802884 0.0048896576035535 no 83 0.00580617394739725 139 580690
SGTC_411 enrofloxacin 100 µM 2.50049344318414 0.00522949909950339 no 84 0.00620102143839924 78 71188 A bacterial gyrase inhibitor.
SGTC_3300 9124615 50.48 µM 2.4892236628151 0.00540191381959673 no 85 0.00640111991583331 129 24824903
SGTC_649 1123-0311 367 µM 2.42947139736015 0.00640317827191529 no 86 0.00756042898042725 199 693629 YIL048W NEO1
SGTC_951 1171-0579 82.7 µM 2.40709667616251 0.00681841700594919 no 87 0.00803995628295396 236 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2718 lomofungin 53.02 µM 2.38632320819264 0.00722505077833522 no 88 0.00850889372199804 87 5351222 A RNA synthesis inhibitor.
SGTC_81 0411-0046 9.971 µM 2.3656724897204 0.00765032933660752 no 89 0.00899867871634023 127 12925265
SGTC_2426 5582046 32.21 µM 2.36419541238112 0.00768157594392225 no 90 0.0090346394003732 151 2251934
SGTC_1171 0368-0077 21.4 µM 2.35652735576857 0.0078456007500029 no 91 0.00922335445343485 104 3239779
SGTC_2835 9006588 71.43 µM 2.34959418932696 0.0079965500112636 no 92 0.00939694423867425 178 2345538
SGTC_989 1501-0895 10.3 µM 2.3342977457278 0.00833864582768784 no 93 0.00979006834992135 97 2830112
SGTC_577 r071-0003 38.6 µM 2.33128897348471 0.00840742759159006 no 94 0.00986906362920924 228 4568517 YMR134W ERG29
SGTC_938 3126-1755 342 µM 2.31422450417124 0.00880702895600337 no 95 0.0103277052498091 133 1777771
SGTC_2982 9019404 25.97 µM 2.30645283477293 0.00899447149345931 no 96 0.010542671334748 149 22333232
SGTC_349 k015-0014 24 µM 2.30364773378312 0.00906298012592997 no 97 0.0106212130034314 155 2196908
SGTC_316 k060-0003 58.6 µM 2.30128261241321 0.00912109782709275 no 98 0.0106878309594753 129 6152314
SGTC_749 1000-0129 128 µM 2.3002379308833 0.00914687232248293 no 99 0.0107173719884605 154 708470
SGTC_3054 9094397 49.47 µM 2.29847905073084 0.00919041167083891 no 100 0.0107672694381633 188 2598354
SGTC_1832 st054113 55 µM 2.29268266723358 0.00933518203340762 no 101 0.0109331405697358 102 1251267
SGTC_2233 sulbentine 40.3845 µM 2.29246032696738 0.0093407747120263 no 102 0.0109395471676279 217 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1297 1068-0111 14.1 µM 2.28828092207147 0.00944644894110346 no 103 0.0110605833954261 133 767057
SGTC_558 k064-0027 21.3 µM 2.28762174181367 0.00946321109819251 no 104 0.0110797793186464 151 5088526
SGTC_1578 josamycin 24.2 µM 2.28745363506317 0.00946749000980055 no 105 0.0110846793731637 130 5282165 A P450 substrate.
SGTC_308 4092-1169 104 µM 2.27972584298225 0.00966602497236052 no 106 0.0113119767924708 187 2268590 YDL196W YDL196W
SGTC_869 0564-0080 44.1 µM 2.27762568174619 0.0097206050925022 no 107 0.0113744445173924 167 6843321
SGTC_1392 3455-1037 33.9 µM 2.2775016667104 0.00972383646493132 no 108 0.0113781426061679 134 981132
SGTC_2802 7925815 54.55 µM 2.27297948516791 0.00984231060287748 no 109 0.0115137081152106 190 1262923
SGTC_2041 5107442 45.335 µM 2.27236112959348 0.00985860813884828 no 110 0.0115323537120773 182 793005
SGTC_1996 st072960 66.8 µM 2.25934774988427 0.0102071009717111 no 111 0.0119308809239933 144 1719405
SGTC_1631 benzylvanillin 81.9 µM 2.24933296321747 0.0104825625903433 no 112 0.0122456600641149 169 75506
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 2.24415254677372 0.010627578253109 no 113 0.0124112940113107 160 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_52 0329-0193 875 nM 2.22741804550556 0.0111080325691548 no 114 0.0129596737446689 169 3739292
SGTC_1771 st048882 4.1505 µM 2.22102980898739 0.0112963623591196 no 115 0.0131744712338154 154 4580403
SGTC_911 3456-4043 236 µM 2.20720075522665 0.0117135814854634 no 116 0.0136500185205366 193 914281
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 2.20222490284771 0.0118669403201873 no 117 0.0138247129076252 231 688788
SGTC_142 0335-0849 62.6745 µM 2.20097149350932 0.0119058447267319 no 118 0.0138690209849898 329 3889043 YPR107C YTH1
SGTC_905 2-aminofluorene 215 µM 2.19779239280454 0.0120050169558033 no 119 0.0139819518994532 186 1539 An established DNA mutagen. YPR165W RHO1
SGTC_884 0851-0618 334 µM 2.19546993575036 0.0120779182171656 no 120 0.0140649526018069 180 9642473
SGTC_1826 st055655 41.6 µM 2.18660073989742 0.0123598624665346 no 121 0.0143858416470445 195 676168
SGTC_401 neomycin 50 µM 2.17960579681294 0.0125862300785078 no 122 0.0146433473725335 139 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1080 nisoldipine 24.4 µM 2.17356815255769 0.0127844948836771 no 123 0.0148687911728506 190 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2207 7258803 200 µM 2.13870316206759 0.0139830475284045 no 124 0.016229858187395 120 3666799
SGTC_2910 7948405 25.97 µM 2.13096004557198 0.014262005606786 no 125 0.0165462169515496 161 2971328
SGTC_935 2996-0153 430 µM 2.11180771276799 0.014972670191476 no 126 0.0173514727474656 165 23738523
SGTC_2443 5493264 126.67 µM 2.10815994913648 0.0151114204791583 no 127 0.0175085781686218 172 5340055
SGTC_561 1550-0330 72.9 µM 2.0969819669708 0.0155434990792314 no 128 0.0179975858527434 162 6812934
SGTC_3190 9110366 49.47 µM 2.05850513231118 0.01711279587039 no 129 0.019770834554518 145 17123768
SGTC_1850 st056238 17 µM 2.05240946670553 0.0173734392912873 no 130 0.0200649426424255 212 5393177
SGTC_587 k089-0003 57 µM 2.04963260404963 0.0174932941384948 no 131 0.0202001481476171 101 9659696
SGTC_1437 4092-1038 11.6 µM 2.04277684905681 0.0177922285806865 no 132 0.0205372666609209 200 3977136
SGTC_2569 tetrandrine 100 µM 2.04191529830744 0.0178301016153675 no 133 0.0205799669967439 190 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2694 st077685 81.9 µM 2.03806671916589 0.0180001226714918 no 134 0.020771630465091 229 2838096
SGTC_2639 lactacystin 53 µM 2.03156994844014 0.0182902709962298 no 135 0.0210986057821558 219 3870 A proteasome inhibitor.
SGTC_2813 7971799 71.43 µM 2.0298147638551 0.0183693385507088 no 136 0.0211876858364715 199 2234054
SGTC_672 1441-0018 53.7 µM 2.01988055599265 0.0188223629442728 no 137 0.0216978893084568 199 251141
SGTC_3007 9078383 71.4286 µM 2.01717940369206 0.0189471735863485 no 138 0.0218383973188532 215 6496995
SGTC_856 0433-0016 11.3 µM 2.01603543013735 0.0190002443480026 no 139 0.021898135535008 214 3911780
SGTC_295 k015-0027 31 µM 2.01599343154264 0.01900219513337 no 140 0.0219003313220266 192 3887424
SGTC_371 0195-0006 7.36 µM 2.01044186771462 0.0192615625226567 no 141 0.0221922215128927 179 3928593
SGTC_2916 7875993 68.79 µM 2.00498382621634 0.0195194876550204 no 142 0.0224823880707177 235 1299250
SGTC_1398 3558-0053 112 µM 2.0036668892171 0.0195821582620371 no 143 0.0225528776917141 149 4532369
SGTC_466 geldanamycin 89.2 µM 2.00057788786218 0.0197298289155708 no 144 0.0227189492492743 133 5288382 HSP90 inhibitor.
SGTC_2278 7948257 134.34 µM 1.98340987947267 0.0205678862823683 no 145 0.0236608322400272 209 1247028
SGTC_823 0417-1665 178 µM 1.9737995007923 0.0210500471977243 no 146 0.0242022728210895 241 3429856
SGTC_59 0330-0160 1.33 µM 1.96740358145378 0.0213762088541265 no 147 0.024568350894867 416 4293482
SGTC_1464 k208-0027 110 µM 1.96573014211678 0.0214622482078999 no 148 0.0246648955318928 219 X1464
SGTC_2476 5806916 10.51 µM 1.96557430710186 0.0214702752947887 no 149 0.0246739021980433 192 2870194
SGTC_179 1273-0063 6.77 µM 1.96547587221316 0.0214753469995431 no 150 0.0246795927789197 199 3108139
SGTC_2654 protoveratrine a 100 µM 1.959953593558 0.021761500304267 no 151 0.0250006073078558 201 5702278 A heart drug and vasodilator.
SGTC_1388 3346-4487 254 µM 1.95717705115163 0.0219065877123175 no 152 0.0251633279714904 252 3345614
SGTC_382 3229-0966 23.2 µM 1.95443378893054 0.0220507374295196 no 153 0.0253249690019083 238 5722370
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.95291628514149 0.0221308208350003 no 154 0.025414757841039 250 6708784 An antioxidant flavonoid
SGTC_2126 5251174 33.877 µM 1.95162036896281 0.0221994045571404 no 155 0.0254916465509854 313 790722
SGTC_3231 9132313 49.47 µM 1.9455963338558 0.0225205734063425 no 156 0.0258516238747071 208 4905967
SGTC_798 1287-0182 476 µM 1.94514597577808 0.0225447406583573 no 157 0.0258787058941892 267 1649755
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.94190343739026 0.0227193890181053 no 158 0.0260743956048689 238 6312947
SGTC_1920 st075728 45.7 µM 1.93276339818981 0.0232178341450574 no 159 0.0266326755988684 244 3400306
SGTC_528 3492-0019 172 µM 1.92482407971401 0.0236582397358075 no 160 0.0271256852172149 511 2869262
SGTC_1024 4507-0395 26 µM 1.92068108750479 0.02389083346292 no 161 0.0273859626752589 243 4201836
SGTC_1428 4049-0204 61.7 µM 1.91745431260466 0.0240733181389509 no 162 0.0275901199489889 230 X1428
SGTC_3139 9095020 49.47 µM 1.91740361615025 0.0240761945072615 no 163 0.0275933375965639 149 25236292
SGTC_2212 7123476 200 µM 1.91504552399733 0.0242103051711724 no 164 0.0277433490947419 148 1085715
SGTC_902 1120-0002 2.07 µM 1.91344608362337 0.0243016260487844 no 165 0.0278454847959275 296 3280475
SGTC_1359 1582-0056 520 nM 1.9068679967522 0.0246802519728416 no 166 0.0282688416780045 279 3661189
SGTC_2747 doxorubicin 7.63 µM 1.90248028421497 0.0249355446940515 no 167 0.0285541969841809 117 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2369 9071472 200 µM 1.89234484163771 0.0255337352910382 no 168 0.0292225250071713 255 17296037
SGTC_1733 st037357 54.9 µM 1.88993750300458 0.025677568280679 no 169 0.0293831595294866 281 1272339 YGL099W LSG1
SGTC_2288 7946289 167.31 µM 1.88837275838988 0.0257714214153644 no 170 0.0294879629153383 300 1246052
SGTC_2647 atorvastatin 60.16 µM 1.88575262270962 0.0259292195455084 no 171 0.0296641490081748 237 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2919 7978188 46.38 µM 1.88507515519334 0.0259701514166389 no 172 0.0297098459032656 251 2980291
SGTC_3127 9126946 49.47 µM 1.8821920526904 0.0261449504064208 no 173 0.0299049721608097 230 27243249
SGTC_21 0849-0113 22.993 µM 1.87472664632839 0.0266021458515307 no 174 0.0304151695655263 276 1560156
SGTC_3281 9140613 49.47 µM 1.87426617609952 0.02663056324091 no 175 0.0304468735160466 223 16013766
SGTC_1257 0669-0121 16 µM 1.86886234720569 0.0269659533316429 no 176 0.0308209839960621 301 4307855
SGTC_1097 itavastatin 7.23 µM 1.86534298509715 0.0271862737264476 no 177 0.0310666717900656 281 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1480 1070-0044 41.2 µM 1.85918236801005 0.0275755579322903 no 178 0.031500646586385 265 3124987
SGTC_2812 7970281 58.44 µM 1.85611891102247 0.027770858386967 no 179 0.0317183054013222 299 2233435
SGTC_114 0364-0001 490.298 µM 1.8508014145431 0.0281125937401427 no 180 0.0320990637557071 305 4003655
SGTC_1313 1220-0047 237 µM 1.84864349476244 0.0282522703215643 no 181 0.0322546539092429 333 3528706
SGTC_627 1391-0720 175 µM 1.84824361860741 0.0282782166075423 no 182 0.0322835539954635 250 997839
SGTC_2237 6667747 47.222 µM 1.84698115984077 0.0283602624408229 no 183 0.0323749354320657 230 729940 YDL015C TSC13
SGTC_3250 9135583 49.47 µM 1.84608723282477 0.0284184775090358 no 184 0.0324397701617804 211 7699353
SGTC_624 k048-0052 28 µM 1.83889588393777 0.0288904251775992 no 185 0.0329652506684543 248 6835531
SGTC_3153 9100258 49.47 µM 1.83401869781595 0.029214194142901 no 186 0.0333256093401959 290 25236848
SGTC_1667 st014849 34.6 µM 1.8325784298993 0.0293103798701861 no 187 0.0334326441693097 239 5348460
SGTC_956 1185-0240 191 µM 1.8324252220229 0.0293206270437034 no 188 0.0334440465899135 265 1416193
SGTC_747 3448-8087 38.7 µM 1.82609235630941 0.0297468054433818 no 189 0.0339181756961109 295 5168703
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.82413852674681 0.0298793237745601 no 190 0.0340655661558502 378 6708739 YPR165W RHO1
SGTC_948 3448-0295 75.3 µM 1.81962934211406 0.0301870287172036 no 191 0.0344077350718575 308 678569
SGTC_564 3555-0129 330 µM 1.8195513542772 0.0301923735969742 no 192 0.0344136777495786 189 563260
SGTC_152 4469-0003 551.229 µM 1.80834486576091 0.0309686036143409 no 193 0.0352764215707536 264 697280
SGTC_2563 tomatine 8.54 µM 1.80667013077634 0.031086012237861 no 194 0.0354068637773267 356 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_476 mead acid 10 µM 1.79128387413574 0.0321820055582952 no 195 0.0366238762745833 182 5312531 An omega 9 fatty acid.
SGTC_563 tetrahydrosecaminediol 614 µM 1.78915701457169 0.0323359855055931 no 196 0.036794766099538 298 334274 A psychoactive constituent of the cannabis plant.
SGTC_439 amiodarone 34.4 µM 1.78449692149439 0.0326754919300426 no 197 0.0371714772989783 372 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2981 9013952 38.96 µM 1.77860161271765 0.0331091946832565 no 198 0.0376525497623828 297 2996344
SGTC_2358 9037157 4 µM 1.77747708855617 0.0331924593000063 no 199 0.0377448886039834 298 2388925
SGTC_2871 9038510 12.99 µM 1.77494486201226 0.0333805879046986 no 200 0.0379534959128685 299 4945164
SGTC_973 1325-0077 65.9 µM 1.77459046178076 0.0334069875309302 no 201 0.0379827666482116 304 2835149
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.76957874653875 0.0337821591004236 no 202 0.0383986709889722 247 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2676 harmalol 100 µM 1.76922325763688 0.0338089017535646 no 203 0.0384283121969709 294 5459187 A monoamine oxidase inhibitor
SGTC_3352 9151559 45.5865 µM 1.76648364477034 0.0340155816715623 no 204 0.0386573715420479 280 17159339
SGTC_3024 9090631 49.47 µM 1.76629801867445 0.0340296230466652 no 205 0.0386729319167255 231 25236383
SGTC_472 calcifediol 10 µM 1.75826672414369 0.0346417161340155 no 206 0.0393510683883574 221 5283731 A vitamin D metabolite.
SGTC_2570 licareol 100 µM 1.7545948829676 0.0349245569543582 no 207 0.0396643136766738 315 443158
SGTC_2400 5203494 178.7 µM 1.75267505992545 0.0350731933437078 no 208 0.0398288995193677 279 6777674
SGTC_2832 7992762 51.95 µM 1.7493871517278 0.035328955058839 no 209 0.0401120601301747 278 2985177
SGTC_2430 5571206 200 µM 1.7299340192709 0.0368736566863825 no 210 0.0418210321816366 365 1731771
SGTC_1120 ficusin 1.78878 µM 1.7297504682272 0.0368884906521814 no 211 0.0418374337534348 295 6199 A DNA cross-linker.
SGTC_2781 5567276 71.43 µM 1.72718193613702 0.0370965829291576 no 212 0.0420674969757302 335 2853274
SGTC_583 1488-1091 88.9 µM 1.72292648906899 0.0374434530641304 no 213 0.0424509097098613 380 4303273
SGTC_1164 k060-0068 93.7 µM 1.7218542197102 0.0375312724891101 no 214 0.0425479649082462 337 5963676
SGTC_358 0075-0058 9.45 µM 1.72127624984748 0.037578678242573 no 215 0.0426003535491933 430 1069125
SGTC_1227 3909-8010 46.6 µM 1.72017701565401 0.0376689736086749 no 216 0.0427001348223282 307 15982272
SGTC_1275 0867-0008 21.1 µM 1.71812046029147 0.0378383826982043 no 217 0.0428873227976952 323 3422836
SGTC_1165 k072-0275 30.3 µM 1.71700400638328 0.0379306108494288 no 218 0.0429892199856173 305 6153523 YGL055W OLE1
SGTC_1784 st039334 36.3 µM 1.71371384442507 0.0382034721219571 no 219 0.0432906465115606 318 3496984
SGTC_1761 st044296 37 µM 1.71123171803541 0.0384103785622244 no 220 0.0435191728194364 324 1826700
SGTC_3262 9137218 49.47 µM 1.70889485808659 0.038606009751488 no 221 0.0437352135775916 157 17650664
SGTC_2335 9018011 154.17 µM 1.70799537577758 0.0386815263525112 no 222 0.0438186002554177 350 6458208
SGTC_3183 9108214 49.47 µM 1.70490188880569 0.0389421611582181 no 223 0.0441063620297422 173 4974831
SGTC_189 3970-0742 2.116 µM 1.70267051657713 0.0391310467841653 no 224 0.0443148726911239 266 2891807
SGTC_2849 9019321 12.99 µM 1.69804796505893 0.0395247185827172 no 225 0.0447493546772494 319 16489627
SGTC_2976 9009005 19.48 µM 1.69549748237134 0.0397433014550579 no 226 0.0449905437228583 315 2993148
SGTC_1136 pergolide 1.05886 µM 1.69310771310806 0.0399490016744263 no 227 0.0452174832004258 440 47811 A dopamine receptor agonist.
SGTC_883 0850-0245 24.6 µM 1.69299940008651 0.0399583452139768 no 228 0.0452277906993129 357 6823229 YPR165W RHO1
SGTC_120 rhodamine 6G 52.259 µM 1.68932870327902 0.0402760464595989 no 229 0.0455782278492754 416 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_361 000s-0510 1.45 µM 1.68289040757963 0.0408382382052928 no 230 0.0461981544434488 362 660
SGTC_2375 9072683 200 µM 1.68174099224509 0.0409392717461006 no 231 0.0463095377202545 360 16798029
SGTC_1335 1486-0900 202 µM 1.6795451196201 0.0411328524558771 no 232 0.0465229265707216 371 X1335
SGTC_2705 st078069 42.8 µM 1.67394196588341 0.0416301721952906 no 233 0.0470710027375395 306 1530061
SGTC_2211 7117706 200 µM 1.67113454503166 0.0418811762572452 no 234 0.0473475526842006 294 822771
SGTC_648 0375-0473 33.3 µM 1.67081943662676 0.0419094255915173 no 235 0.0473786740984854 375 1713139
SGTC_1098 clofazimine 15.1 µM 1.66580984087609 0.0423606094120871 no 236 0.0478756477287661 378 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2215 7188065 200 µM 1.65314744457897 0.0435185672924082 no 237 0.0491504297249772 261 940217
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.64617866780616 0.0441666714613073 no 238 0.0498634899186757 353 390807
SGTC_1106 tegaserod maleate 11.7 µM 1.6461662111686 0.044167836871389 no 239 0.0498647718569823 383 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_864 0469-0573 172 µM 1.63967401680014 0.04477861094429 no 240 0.0505364821045271 334 689425
SGTC_3249 9135183 49.47 µM 1.63809534816415 0.0449281525996961 no 241 0.0507009026218365 362 4902779
SGTC_1767 st044992 70.3 µM 1.63302957026797 0.0454107322469316 no 242 0.0512313888334501 384 9600693
SGTC_756 0508-1999 28.3 µM 1.63251276422258 0.0454601980483217 no 243 0.0512857558846114 347 6753853
SGTC_1203 3992-3522 103 µM 1.63071262682172 0.0456328356145121 no 244 0.0514754854981383 389 5322312
SGTC_2914 7968218 45.32 µM 1.63027063436544 0.0456753042608619 no 245 0.0515221555567703 289 2977111
SGTC_1033 k072-0102 21.3 µM 1.62668780646626 0.0460207324182412 no 246 0.0519017098866159 405 5965931
SGTC_1421 4029-0249 71.4 µM 1.62582917704518 0.0461038256940174 no 247 0.0519929998268472 374 2894095
SGTC_18 0111-0177 500 nM 1.62028513064241 0.0466432519914105 no 248 0.0525855207633497 470 721752
SGTC_1386 3228-0095 33.8 µM 1.61957819097007 0.0467123986040483 no 249 0.0526614587878827 331 870181
SGTC_2855 9016525 58.44 µM 1.61863804891687 0.0468044824038986 no 250 0.0527625817232722 367 43811474
SGTC_2588 indole-3-carbinol 100 µM 1.61637655019466 0.0470265851820626 no 251 0.0530064626017381 426 3712 Induces cell cycle arrest.
SGTC_2730 imipramine 71.33 µM 1.60682518624853 0.0479739663298931 no 252 0.0540463608029194 445 3696 A tricyclic antidepressant.
SGTC_2479 5617353 43.85 µM 1.60027061316695 0.0486328957339147 no 253 0.0547692815589507 384 2731746
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.59909438121323 0.0487519041533467 no 254 0.054899816489675 392 688801
SGTC_2439 5492030 7.2 µM 1.59806657261013 0.0488560858989422 no 255 0.0550140809980412 341 5722370
SGTC_3133 9127736 49.47 µM 1.59520831638951 0.0491467427829121 no 256 0.0553328298307474 370 27243420
SGTC_84 0443-0269 128.823 µM 1.59509721771223 0.0491580682626495 no 257 0.055345248787596 390 6150058
SGTC_1212 0520-0165 585 µM 1.5929583423536 0.0493765133847563 no 258 0.0555847683072664 391 5403258
SGTC_3032 9089427 49.47 µM 1.58626732280314 0.0500648803372583 no 259 0.0563393408172515 340 17173707
SGTC_2843 9000894 45.46 µM 1.58521079449171 0.0501742713292123 no 260 0.0564592243834716 244 2242070
SGTC_1255 0566-0045 221 µM 1.58298731701069 0.0504051084952629 no 261 0.0567121775984724 400 2788469
SGTC_1526 st051518 75 µM 1.58164735203121 0.0505446292432538 no 262 0.0568650488790093 336 673993
SGTC_1362 1611-0397 101 µM 1.58118041255739 0.0505933204542353 no 263 0.0569183963295804 366 27816
SGTC_976 1348-1067 47.6 µM 1.57846747178807 0.050876958317056 no 264 0.0572291276327049 430 5310671 YGL099W LSG1
SGTC_3287 9117173 37.0625 µM 1.57548797205367 0.0511899220395082 no 265 0.0575719263140841 290 2789709
SGTC_722 3534-0461 190 µM 1.57531481337346 0.0512081574516798 no 266 0.0575918981903116 396 658262
SGTC_2680 butyl paraben 22.24 µM 1.5712302229913 0.0516398081691943 no 267 0.0580645911352582 318 7184 An antifungal and steroid mimetic.
SGTC_599 1935-0052 86.5 µM 1.56383601373466 0.0524285659665264 no 268 0.0589280421676751 407 9557311
SGTC_1355 1499-0035 1.68 µM 1.56268601634607 0.0525520938522598 no 269 0.0590632325462031 380 1548538
SGTC_1216 1165-0504 9.65 µM 1.55520448112077 0.0533613780536218 no 270 0.0599486887106284 403 6304004
SGTC_1674 st016616 23.6 µM 1.55280096178402 0.0536234549032678 no 271 0.060235346436359 400 625830
SGTC_631 k072-0230 41.5 µM 1.55246812035663 0.0536598277697716 no 272 0.0602751274855046 426 5773147
SGTC_2110 5483698 200 µM 1.55189347711182 0.0537226706988414 no 273 0.06034385696931 371 2848765 YHR062C RPP1
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.5452469135459 0.054453781869563 no 274 0.0611432753653841 496 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2008 4012253 172 µM 1.54041340776963 0.054990385196873 no 275 0.0617298076278829 440 603940
SGTC_2959 9079155 11 µM 1.53883788771011 0.0551661955164845 no 276 0.0619219388782653 348 16189457
SGTC_3315 9136395 68.55 µM 1.53146804216644 0.0559944907188384 no 277 0.0628268794290258 412 16876844
SGTC_1710 st031758 61.5 µM 1.52380592415971 0.0568660030948472 no 278 0.0637785996249152 367 5394341
SGTC_687 k029-0044 34.9 µM 1.52265054747909 0.0569983410012744 no 279 0.063923078183236 420 5829338
SGTC_2012 4023501 200 µM 1.52120972416741 0.0571637138289516 no 280 0.0641036079875317 393 3477460
SGTC_2306 7482397 179.52 µM 1.52106044073613 0.0571808696457143 no 281 0.0641223352850706 406 891448
SGTC_3313 9133968 57.047 µM 1.51534835712864 0.0578403578454963 no 282 0.064842104109639 421 1494643
SGTC_3316 9136639 10.545 µM 1.51331298511644 0.0580767912988133 no 283 0.0651000879341904 385 4903665
SGTC_1975 st070967 30.8 µM 1.51231074505753 0.0581934925104663 no 284 0.06522741441258 452 261391
SGTC_312 4092-0653 6.84 µM 1.51159871007207 0.0582765140145594 no 285 0.0653179900244305 523 1148278
SGTC_1200 1643-0193 18.4 µM 1.50643234697641 0.058881688710838 no 286 0.0659781110638767 441 5403974
SGTC_1516 st013856 110 µM 1.50416000898943 0.0591494212115648 no 287 0.0662700860042893 382 5281404 A mutagen and neurotoxin.
SGTC_967 1306-0166 352 µM 1.49587564257856 0.0601335985131089 no 288 0.0673430323692243 435 4437607
SGTC_457 grayanotoxin iii 135 µM 1.49564959948036 0.0601606308846632 no 289 0.0673724953398339 518 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_788 1182-0090 188 µM 1.49535333844847 0.0601960749854587 no 290 0.0674111257610193 553 5715185
SGTC_3205 9113483 49.47 µM 1.49352730256107 0.0604148994297131 no 291 0.0676496064687156 464 17018033
SGTC_14 0354-0009 295 µM 1.49345168861192 0.0604239740907116 no 292 0.067659495703887 427 1713507
SGTC_855 0428-0020 25 µM 1.49244612777089 0.0605447559541545 no 293 0.067791115049727 375 6812414
SGTC_161 4065-0411 162.148 µM 1.49232724089375 0.0605590484012493 no 294 0.0678066893928459 507 1906281 YLR208W SEC13
SGTC_1217 1183-1422 255 µM 1.48987125862727 0.0608548947081081 no 295 0.0681290450162725 431 2849664
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.48885934701326 0.060977117278278 no 296 0.0682622052974446 460 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1236 0330-0013 258 µM 1.48739414625611 0.0611544298449895 no 297 0.0684553710257019 391 4617066
SGTC_13 0199-0087 65 µM 1.48612313483898 0.0613085685654139 no 298 0.0686232770048137 441 4589825
SGTC_2827 7993847 71.43 µM 1.48602251859009 0.0613207835021178 no 299 0.0686365823920488 372 2985692
SGTC_3177 9107506 49.47 µM 1.48307233737492 0.0616797850207842 no 300 0.0690275963458173 351 8897194
SGTC_1665 st014639 11.4 µM 1.48177226152029 0.0618385085826172 no 301 0.0692004510714765 480 981133 YIL048W NEO1
SGTC_1805 st050013 60.3 µM 1.47727523547844 0.0623900008268758 no 302 0.0698009367459171 376 4037144
SGTC_1637 st007924 17.4 µM 1.47473475927243 0.0627032428300855 no 303 0.0701419335935358 432 683336
SGTC_283 0987-0079 11.7 µM 1.4693566716816 0.0633704064831337 no 304 0.0708680364660492 481 411556
SGTC_3228 9131799 49.47 µM 1.45926654589314 0.0646370031771208 no 305 0.0722458796656546 426 17015818
SGTC_686 1319-0111 510 µM 1.45360085595325 0.065356778736983 no 306 0.0730284997395975 474 4562600
SGTC_2651 TUB2.036 5 µM 1.45278882146644 0.0654604479482478 no 307 0.0731411983046387 655 15992207 YFL037W TUB2
SGTC_1115 galangin 695.678 nM 1.45010547392697 0.0658039274299517 no 308 0.0735145544448046 486 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1579 chlormadinone acetate 49.4 µM 1.4494510546055 0.0658879073012249 no 309 0.073605829842899 457 45114258 A steroidal progestin.
SGTC_3265 9137266 49.47 µM 1.44630336688942 0.0662930026241011 no 310 0.0740460659167813 376 17224265
SGTC_928 2764-0428 58.7 µM 1.44456072195057 0.0665181023726241 no 311 0.0742906560844769 491 662578
SGTC_1324 1418-0026 34.4 µM 1.43793347159255 0.0673795600171031 no 312 0.0752264657537013 479 1372513
SGTC_3162 9099653 49.47 µM 1.43664231294001 0.0675483933717854 no 313 0.0754098270627445 395 25237511
SGTC_658 3253-0951 102 µM 1.42432038655137 0.0691761085101435 no 314 0.0771768743394434 589 1184878
SGTC_1884 5633444 25 µM 1.4225694795587 0.0694098336305444 no 315 0.0774304983947415 509 5724239
SGTC_407 eburnamonine 100 µM 1.4213238395769 0.0695764815815415 no 316 0.0776113180400924 395 3195
SGTC_2664 lyso-paf C-16 73.48 µM 1.41776996603473 0.0700536299912578 no 317 0.0781289677214288 481 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1453 4237-0541 195 µM 1.41521112950021 0.0703987391850816 no 318 0.0785033011651181 455 739892
SGTC_188 3229-0966 278.469 µM 1.41129783623616 0.0709290495712781 no 319 0.0790784061186144 563 5722370
SGTC_2611 pyromycin 23.93 µM 1.40830091602407 0.0713372483158357 no 320 0.0795209922710474 478 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_87 0100-0052 35.5 µM 1.40376623821966 0.0719583243049785 no 321 0.0801942353202694 707 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1158 4092-0494 91.8 µM 1.4030078736751 0.0720625944528905 no 322 0.0803072455197087 492 1148199
SGTC_2783 7738165 71.43 µM 1.40136976631733 0.0722882187420774 no 323 0.0805517641822969 379 17201110
SGTC_753 1322-0200 289 µM 1.40010411122887 0.0724629138193653 no 324 0.0807410720593439 470 5403907
SGTC_122 0236-0016 402.397 µM 1.3973560338397 0.0728433370820487 no 325 0.0811532667033902 557 6808838
SGTC_2711 st079103 59.1 µM 1.39512421364491 0.0731534171564363 no 326 0.0814891927998118 444 54693780
SGTC_2181 6316240 54.2555 µM 1.39061010950569 0.073783674539331 no 327 0.0821718445366971 448 12779990
SGTC_2936 9038235 15.59 µM 1.39008288842745 0.0738575547829815 no 328 0.0822518543863594 476 4749415
SGTC_671 0560-0003 407 µM 1.38927755003762 0.0739705171209303 no 329 0.0823741839183462 465 3238678
SGTC_363 0455-0021 3.06 µM 1.38779625782092 0.0741786380700949 no 330 0.0825995473362936 520 4597466
SGTC_1446 4239-0190 62 µM 1.38747391206698 0.0742239867128277 no 331 0.0826486503614859 531 1340085
SGTC_710 3448-4187 58 µM 1.38478387552399 0.0746032557562951 no 332 0.083059281421331 595 3946412
SGTC_1973 st070275 50.2 µM 1.38073255500286 0.0751772414921015 no 333 0.0836806038221209 438 17118334
SGTC_670 4204-0025 119 µM 1.37840935648238 0.0755079048347044 no 334 0.0840384681158481 523 719039
SGTC_2269 7935389 174.42 µM 1.37825454153188 0.0755299791394239 no 335 0.0840623565047966 491 97605
SGTC_2058 5236698 133 µM 1.37591896762866 0.0758635941300892 no 336 0.0844233610787835 501 766665
SGTC_937 3122-0005 46.7 µM 1.37485974048607 0.0760152642418635 no 337 0.0845874663929472 520 759535
SGTC_3039 9090270 49.47 µM 1.3676260465198 0.0770572308285784 no 338 0.0857145795970626 457 17173750
SGTC_3094 9117742 49.47 µM 1.36473622897417 0.0774765114427912 no 339 0.0861679842334454 529 17149698
SGTC_3210 9128157 49.47 µM 1.36000514259479 0.0781666766246388 no 340 0.0869141482639479 492 17590849
SGTC_2074 5212007 75.395 µM 1.35876831559338 0.078347870083145 no 341 0.0871100082193301 428 758611
SGTC_375 3970-0961 9.27 µM 1.35603554854203 0.0787493457188129 no 342 0.0875439288649378 505 2898222
SGTC_2657 nystatin 74.44 µM 1.3553276868879 0.078853592681359 no 343 0.0876565887970429 526 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1991 st073000 8.92 µM 1.35476736172832 0.0789361860153133 no 344 0.087745844189498 566 4301969 YIL048W NEO1
SGTC_1318 1280-3875 124 µM 1.35388932872838 0.0790657420582644 no 345 0.0878858442757266 542 373245
SGTC_397 arbidol 50 µM 1.35315585423592 0.0791740915144436 no 346 0.088002922536243 536 131410 A RNA synthesis inhibitor.
SGTC_3345 9148410 3.559 µM 1.35075701807862 0.0795292347220545 no 347 0.0883866403900832 453 4903596
SGTC_717 1532-0246 73.2 µM 1.35032025840536 0.0795940256956564 no 348 0.0884566384316259 530 9561992
SGTC_910 3454-3003 490 µM 1.34918036371195 0.0797633111373583 no 349 0.0886395201732117 543 820824
SGTC_1686 st019653 115.5 µM 1.34551852830168 0.0803089720958103 no 350 0.0892289209784042 491 97252
SGTC_2543 pimpinellin 60.67 µM 1.34208682318533 0.080822896787087 no 351 0.0897839229030856 487 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1641 st009299 47.1 µM 1.33682453656667 0.081615783030622 no 352 0.0906399590077152 453 4046054
SGTC_2187 6125751 200 µM 1.33282615010114 0.0822221436407152 no 353 0.091294431014496 536 874498
SGTC_2522 biochanin a 4.94 µM 1.33191654259691 0.0823605593770418 no 354 0.0914438072186109 482 5280373 A possible chelator.
SGTC_918 glabranin 770.725 nM 1.32855912434977 0.0828729797650544 no 355 0.0919967326010939 543 124049 Also referred to as licorice root.
SGTC_725 1497-0963 19 µM 1.3269421218534 0.0831206262053373 no 356 0.0922639146066044 540 3549977
SGTC_2420 aureobasidin a 50 nM 1.32675775406401 0.0831488977243372 no 357 0.0922944146683132 562 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1490 4089-0339 670 nM 1.32613442872731 0.0832445338816638 no 358 0.0923975869733179 492 742542
SGTC_2764 methyldopa 94.69 µM 1.32540051905885 0.0833572428618174 no 359 0.0925191724758623 545 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1413 3910-0535 34.4 µM 1.32191283803888 0.0838944260474014 no 360 0.0930985884625683 531 2876951
SGTC_1201 1889-3372 45.9 µM 1.32143144036544 0.0839687761005418 no 361 0.0931787742708132 503 5392199
SGTC_1868 st057644 42.7 µM 1.31986025788039 0.0842117835794745 no 362 0.0934408392811316 564 688665
SGTC_945 3381-0768 11.3 µM 1.31736964847113 0.0845980755576169 no 363 0.0938573747688386 559 1126236 YIL048W NEO1
SGTC_2699 st077704 54.6 µM 1.31730635666695 0.0846079093654895 no 364 0.0938679776694395 530 645852
SGTC_26 0302-0163 425.158 µM 1.31623289900697 0.0847748258139587 no 365 0.0940479423389412 521 3100915
SGTC_3244 9134489 49.47 µM 1.31545734308425 0.0848955738255677 no 366 0.0941781222448898 529 16584271
SGTC_2515 chrysin 20.77 µM 1.30812897737019 0.0860429152568825 no 367 0.0954147831940763 551 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_3010 9080089 71.4286 µM 1.30454222263931 0.0866086747035131 no 368 0.0960243866012522 536 17027233
SGTC_1320 1313-0481 95.3 µM 1.30024015788561 0.087290926287162 no 369 0.0967593354910953 546 6813365 YLR208W SEC13
SGTC_536 3852-0578 10.6 µM 1.29864697565198 0.0875445997867528 no 370 0.0970325544300258 551 2869208
SGTC_473 2-arachidonoylglycerol 10 µM 1.29775230143957 0.087687294756486 no 371 0.097186232503499 548 5282280 An endocannabinoid.
SGTC_2413 inermin 26.06 µM 1.29638537587362 0.0879056458652123 no 372 0.0974213739230342 579 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2605 digitonin 300 nM 1.29463704917962 0.0881855122135817 no 373 0.0977227326493535 632 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_785 1270-0111 65.3 µM 1.28853252837933 0.0891679123077994 no 374 0.098780326612986 543 6741994
SGTC_697 0508-1955 564 µM 1.28764063152466 0.0893121244163427 no 375 0.0989355442841778 601 6243113
SGTC_156 3474-0145 5.642 µM 1.28659344176468 0.0894816674440807 no 376 0.0991180153833645 552 2265471
SGTC_1953 st076800 12.1 µM 1.28151571035842 0.0903071622006951 no 377 0.100006292669938 585 297591
SGTC_3073 9114972 49.47 µM 1.28033591147272 0.0904997711379747 no 378 0.100213511483335 498 41905075
SGTC_2460 5552655 174.22 µM 1.27425803422653 0.0914968541447919 no 379 0.101285991949429 550 5401989
SGTC_425 3825-7017 13.1 µM 1.26921985930747 0.0923295256907921 no 380 0.102181329968202 617 3397440
SGTC_2489 cantharidin 73.42 µM 1.26803495685017 0.0925261694740377 no 381 0.102392733649642 578 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2226 7298446 200 µM 1.26803486261211 0.0925261851258885 no 382 0.102392750475708 502 3283010
SGTC_3334 9142812 21.919 µM 1.26644929996823 0.0927898060985638 no 383 0.102676135047946 570 45283678
SGTC_1804 st050076 49.1 µM 1.26418408730536 0.0931673909383447 no 384 0.103081980469534 574 3895976
SGTC_364 0083-0097 67.7 µM 1.26224129318105 0.0934921358393909 no 385 0.103430987091525 572 5207356
SGTC_2966 9084041 48.03 µM 1.26167829740238 0.0935863986256912 no 386 0.103532284653373 552 17741380
SGTC_1379 2144-0755 36.5 µM 1.25437192340979 0.0948160818279013 no 387 0.104853426357812 625 5392327
SGTC_2653 dihydrofissinolide 100 µM 1.25428704975848 0.0948304359236002 no 388 0.104868844639561 544 6857746
SGTC_1643 st009866 20.2 µM 1.25052988558353 0.0954674645616304 no 389 0.1055530225996 548 3156273 YOR207C RET1
SGTC_601 0986-0029 62.9 µM 1.24998158184607 0.0955606924197719 no 390 0.105653137764551 620 24747981
SGTC_1430 4049-0248 69.1 µM 1.2490056873116 0.095726789078164 no 391 0.105831496847694 645 22774488
SGTC_1001 4048-4355 44.4 µM 1.24880947162328 0.0957602104995559 no 392 0.105867384414302 570 21824233
SGTC_958 1222-0007 33 µM 1.24487726728546 0.0964317937191844 no 393 0.106588434122245 639 7312461
SGTC_2545 solidagenone 89.61 µM 1.23414510098473 0.0982823474375297 no 394 0.108574420053016 367 6708572 An anti ulcer agent
SGTC_1396 3511-0007 98.6 µM 1.23405197473262 0.0982985182932369 no 395 0.10859176876018 528 X1396
SGTC_78 0336-0123 156.75 µM 1.23085752385677 0.0988543973917549 no 396 0.109188078252743 547 6765896
SGTC_734 2023-0417 80 µM 1.22656334178936 0.0996052644350338 no 397 0.109993377200807 593 3935732
SGTC_875 0709-0210 25.7 µM 1.22643679880498 0.0996274543832302 no 398 0.110017172601263 645 6251364
SGTC_402 epigallocatechin gallate 10 µM 1.22315452490199 0.100204280168479 no 399 0.110635668900853 630 65064 An antioxidant.
SGTC_2267 7931562 200 µM 1.21978212660327 0.100799479705689 no 400 0.111273739348082 537 934880
SGTC_2299 7976368 114.88 µM 1.21709117741326 0.101276255401528 no 401 0.111784763546761 585 2979718
SGTC_27 0485-0001 32.618 µM 1.21574810503148 0.101514831403769 no 402 0.112040446502225 492 2054479
SGTC_1838 st055369 84.5 µM 1.21309820900337 0.101986744345657 no 403 0.112546137338528 556 676036
SGTC_325 2810-4341 181 µM 1.21228473030761 0.102131934367366 no 404 0.11270170346898 604 774970
SGTC_1333 1482-0047 286 µM 1.21140219742962 0.102289619207633 no 405 0.112870648809741 649 3811116
SGTC_518 1021-0119 62.6 µM 1.21087764386526 0.102383426651862 no 406 0.112971150954253 588 1097762
SGTC_2617 dihydrotanshinone i 20.83 µM 1.20786422432096 0.102923537427991 no 407 0.113549746322753 651 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.20524410236284 0.103394835318019 no 408 0.114054540747759 583 521171
SGTC_3337 9144342 33.5465 µM 1.20520377866516 0.103402100816485 no 409 0.114062322008869 621 17682949
SGTC_2863 9028737 58.44 µM 1.20388732908397 0.103639501458879 no 410 0.114316564927936 579 6460917
SGTC_462 ag-879 158 µM 1.20348483549239 0.103712163627018 no 411 0.114394378086699 659 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2183 6420625 130.508 µM 1.20272442524321 0.103849541348516 no 412 0.1145414893496 683 2897619
SGTC_1374 2889-5571 141 µM 1.20238748252725 0.103910456490421 no 413 0.114606718338907 658 2853281
SGTC_379 3970-0972 5.9 µM 1.20023695626736 0.104299856048515 no 414 0.115023663160684 609 2898042 YBL034C STU1
SGTC_1068 loratadine 26.9 µM 1.19856169187599 0.104603931136793 no 415 0.115349210675609 589 3957 A H1 histamine antagonist.
SGTC_2928 9011484 9.79 µM 1.19667610297821 0.104946949506569 no 416 0.115716412447116 576 2994751
SGTC_994 3910-0338 138 µM 1.19570697184439 0.105123566234825 no 417 0.115905464864699 654 3479481
SGTC_343 4130-2827 29.8 µM 1.1939454994105 0.105445131710818 no 418 0.116249643910463 654 1118244
SGTC_1440 4100-1550 40 µM 1.19391756124732 0.105450237685567 no 419 0.116255108662935 581 742806
SGTC_1828 st055811 49 µM 1.19198107945381 0.105804584722644 no 420 0.116634332105511 569 5877589
SGTC_609 0986-0026 86.3 µM 1.19044254496834 0.10608672634596 no 421 0.116936249764199 643 2848610
SGTC_575 k072-0246 11.9 µM 1.1818671482101 0.107669272752716 no 422 0.11862920949111 647 6796779
SGTC_2602 kawain 100 µM 1.18130140351655 0.107774272996176 no 423 0.118741504978405 704 5369129
SGTC_1237 0330-0133 46.1 µM 1.18050426703653 0.107922343901765 no 424 0.118899857172738 588 X1237 YHR072W ERG7
SGTC_1785 bathophenanthroline 24 µM 1.17739391964878 0.108501502862036 no 425 0.119519157812386 622 72812 An iron chelator.
SGTC_45 0kpi-0036 14.9 µM 1.17497556224095 0.108953353195567 no 426 0.120002246434475 595 2795021
SGTC_3041 9091929 49.47 µM 1.17425024145607 0.109089136774567 no 427 0.120147403702166 663 25236887
SGTC_3218 9131285 49.47 µM 1.16820627993051 0.110225326482745 no 428 0.12136178398574 733 17156417
SGTC_3096 9117468 49.47 µM 1.16312516034834 0.111187060734953 no 429 0.122389362620553 536 41316311
SGTC_861 0443-0273 110 µM 1.16277837276526 0.111252917665263 no 430 0.122459717032996 665 6149169
SGTC_1295 1013-0063 9.78 µM 1.16268231393074 0.111271164721267 no 431 0.122479209954591 677 6826038
SGTC_3257 9139206 32.98 µM 1.16246786362976 0.111311908805452 no 432 0.122522735545567 594 4910041
SGTC_1971 st069429 63.5 µM 1.15952748569795 0.111871637814552 no 433 0.12312061980681 621 1246522 YGL099W LSG1
SGTC_1690 st023502 41.2 µM 1.15802157635557 0.112159080181537 no 434 0.123427615740205 639 24207482
SGTC_25 0118-0223 35.662 µM 1.15597351378887 0.112550853367393 no 435 0.12384599544387 648 5333628
SGTC_807 1315-0151 48 µM 1.1536324672503 0.112999867426993 no 436 0.12432544079466 733 4011080
SGTC_2090 5301565 104.445 µM 1.14862286871362 0.11396500292948 no 437 0.125355761514466 731 2056344
SGTC_2517 totarol 10 µM 1.14838060042053 0.114011826105345 no 438 0.125405739324701 591 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_3118 9124250 49.47 µM 1.14725877591872 0.114228819710181 no 439 0.125637343117835 590 1504786
SGTC_2828 7998861 71.43 µM 1.14437656258915 0.114787671992901 no 440 0.126233751897983 575 2988188
SGTC_2523 spermine 47.74 µM 1.14417043145823 0.11482771458722 no 441 0.126276481548618 646 1103 A DNA binding polyamine.
SGTC_305 1682-2595 20.8 µM 1.14396697807086 0.114867246752119 no 442 0.126318666003719 685 226033
SGTC_1846 st056244 14.8 µM 1.14349124604755 0.114959722007173 no 443 0.126417343611411 707 5393182
SGTC_819 1013-0258 27.7 µM 1.14339120344517 0.114979175542826 no 444 0.126438101548186 668 5753198
SGTC_1498 4478-3555 97.6 µM 1.13849530253118 0.115934058178124 no 445 0.127456859633195 621 3437919
SGTC_1114 scopoletin 1.73284 µM 1.13515681886595 0.116588406869141 no 446 0.128154809200404 671 5280460 A coumarin with genotoxic properties.
SGTC_237 nikkomycin 200 µM 1.13511971742222 0.116595693502999 no 447 0.128162580581582 696 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_3157 9099274 49.47 µM 1.13487153800092 0.116644443646987 no 448 0.128214573414868 652 17217662
SGTC_2993 9054257 71.4286 µM 1.13267052646978 0.11707742321409 no 449 0.128676319651214 668 6470217 YGL055W OLE1
SGTC_2608 thymoquinone 42.66 µM 1.13208431795376 0.117192933037167 no 450 0.128799493617154 630 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1172 0370-0043 85 µM 1.13115221122363 0.117376766789419 no 451 0.12899551600061 659 376585
SGTC_2121 5257820 149.641 µM 1.12942141013367 0.117718663645423 no 452 0.129360052616796 730 791256
SGTC_2108 5365811 200 µM 1.1289357028673 0.117814735212191 no 453 0.129462479117302 690 780283
SGTC_932 2857-0803 154 µM 1.12566187105289 0.118463737572834 no 454 0.130154334325306 732 674898
SGTC_3261 9137475 49.47 µM 1.12375881783479 0.118842156943053 no 455 0.130557678270352 446 17027690
SGTC_1473 k844-0725 134 µM 1.12189547749036 0.119213505953498 no 456 0.130953441901851 772 54682906
SGTC_395 anisomycin 6.25 µM 1.12102925744439 0.119386415353953 no 457 0.131137704430152 614 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_279 1273-0055 2.93 µM 1.11903359623069 0.119785449997357 no 458 0.131562903313517 753 2847562
SGTC_795 0685-0265 78 µM 1.11894592260808 0.119803001973672 no 459 0.131581604996367 701 302754
SGTC_2502 avocadyne acetate 18.59 µM 1.11820513413351 0.119951377830732 no 460 0.131739696023989 746 3952079
SGTC_206 4546-0025 72.014 µM 1.11791381937476 0.120009762046225 no 461 0.131801901143194 766 6620745 YIL048W NEO1
SGTC_467 ro 31-8220 72.8 µM 1.11646281705019 0.120300864847366 no 462 0.132112038868599 720 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_570 0987-0065 62.6 µM 1.11622404238553 0.120348815890878 no 463 0.132163122821894 587 3104428
SGTC_3339 9145883 14.936 µM 1.1144265362994 0.120710225626866 no 464 0.132548122202159 666 2030670
SGTC_3336 9143619 71.43 µM 1.11135421402167 0.121329719743578 no 465 0.133207956054153 752 45595730
SGTC_607 4491-0986 66.8 µM 1.10900948879362 0.12180400502111 no 466 0.133713044295289 714 698981 YDR232W HEM1
SGTC_2477 5967686 25.23 µM 1.10662140609319 0.122288397912621 no 467 0.134228824179551 691 776118
SGTC_2861 9024595 19.48 µM 1.10659497315588 0.122293767061027 no 468 0.134234540821048 585 16482810
SGTC_1370 2001-0092 44.6 µM 1.10651941125104 0.122309116365541 no 469 0.134250883488274 810 790957
SGTC_2690 usnic acid 100 µM 1.10477041580403 0.122664777360803 no 470 0.134629541339285 764 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2748 diazoxide 86.69 µM 1.09916500477734 0.123809532715114 no 471 0.135848050017517 646 3019 A potassium channel activatior.
SGTC_1759 st043059 70 µM 1.0967375379196 0.124307591351282 no 472 0.136378070985161 730 669426
SGTC_2751 anetholtrithion 17.25 µM 1.09543278632663 0.12457587369355 no 473 0.136663538457743 694 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3203 9113543 49.47 µM 1.09445815640739 0.12477654051225 no 474 0.136877044794154 671 17018012
SGTC_1141 3253-0389 52.6 µM 1.09097389118338 0.12549576352039 no 475 0.137642185596299 698 5402031
SGTC_813 k007-0158 173 µM 1.09081658423625 0.125528302985719 no 476 0.1376767987658 798 6523916
SGTC_2890 9046729 58.44 µM 1.08065871917277 0.127641967049989 no 477 0.139924476128855 654 903329
SGTC_2667 digitoxin 100 µM 1.07982568380769 0.127816397562661 no 478 0.140109905852322 638 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_50 0929-0078 56.389 µM 1.07827767747414 0.128140976693315 no 479 0.140454927914745 693 1377751
SGTC_1827 berberine 7.24 µM 1.07418984428533 0.129000845868758 no 480 0.141368801588095 666 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1877 wortmannin 25 µM 1.07229217823495 0.129401373741871 no 481 0.14179440943323 778 312145 A covalent inhibitor of PI 3-kinase.
SGTC_645 0845-0943 5.41 µM 1.07007190546601 0.129871085019237 no 482 0.142293471938962 706 1885106
SGTC_2704 st078022 71.1 µM 1.06977834395003 0.129933277866677 no 483 0.142359546168029 749 54697681
SGTC_1343 1487-0095 224 µM 1.06846753502891 0.130211232511748 no 484 0.142654833612458 734 4560101 YGL055W OLE1
SGTC_469 w7 172 µM 1.06839064258351 0.130227550180112 no 485 0.142672168112543 696 45115570 A P450 inhibitor.
SGTC_3159 9100096 49.47 µM 1.06746716992828 0.130423634724426 no 486 0.142880465454316 705 25236875
SGTC_3034 9090421 49.47 µM 1.06657508251715 0.130613248944602 no 487 0.143081878660854 697 17173761
SGTC_3323 9138564 53.9225 µM 1.06329305814207 0.131312487170509 no 488 0.143824536137849 805 43912313 YNL103W MET4
SGTC_2994 9053520 71.4286 µM 1.05894465978852 0.132242892255 no 489 0.144812491791049 750 4647384
SGTC_1897 st060201 15 µM 1.05624444353205 0.132822925906898 no 490 0.145428275345238 702 611878
SGTC_606 k015-0008 38.6 µM 1.05516599768044 0.13305507579556 no 491 0.145674706083516 825 1970475
SGTC_400 oxethazaine 37.5 µM 1.05260282551516 0.133607953121148 no 492 0.146261530830433 716 4621 A local anesthetic.
SGTC_2932 9016711 44.54 µM 1.05132998912087 0.133883090669558 no 493 0.146553529102135 791 7117328
SGTC_1455 4262-0120 131 µM 1.04020405875687 0.136304661136093 no 494 0.149122553122819 802 1529587
SGTC_2552 juarezic acid 87.02 µM 1.03850522150682 0.136677035651711 no 495 0.149517452806759 903 1549512
SGTC_1279 0874-0590 65.2 µM 1.0356278392673 0.137309325361764 no 496 0.150187899511553 795 3523074
SGTC_990 3985-0011 41.3 µM 1.03339531173848 0.137801285810777 no 497 0.150709469788737 705 5399565 YGL099W LSG1
SGTC_31 0508-1974 57.237 µM 1.03266909496084 0.137961574078669 no 498 0.150879390557744 751 6810525
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.03124926256511 0.138275322249005 no 499 0.151211972313349 716 6708760
SGTC_1300 1094-0077 113 µM 1.02950196914642 0.138662098431319 no 500 0.151621927466657 731 5532636
SGTC_1937 st074714 47.2 µM 1.02897657744249 0.138778541709744 no 501 0.151745340757835 745 17250970
SGTC_705 1124-0212 310 µM 1.02729130636296 0.139152499966638 no 502 0.152141657394862 795 9554485
SGTC_2096 5468907 200 µM 1.02293339904481 0.140122688236237 no 503 0.153169668334286 771 759785
SGTC_3090 9117696 49.47 µM 1.02052294856806 0.140661289106053 no 504 0.153740255631107 778 7923821
SGTC_3168 9103419 49.47 µM 1.01768903645561 0.141296304762185 no 505 0.15441287956018 706 16649256
SGTC_1346 1488-2224 62.4 µM 1.01652242840755 0.141558279044965 no 506 0.15469033633269 799 3722427
SGTC_1525 8-methoxypsoralen 92.5 µM 1.01529334220115 0.141834639255702 no 507 0.154983008559715 863 4114 Related to psoralen; DNA damaging agent.
SGTC_2136 5328288 199.296 µM 1.01296488451879 0.142359194443459 no 508 0.155538467078382 692 262395
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.01268513960698 0.142422303603851 no 509 0.155605289078741 780 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3095 9117207 49.47 µM 1.01262846727932 0.142435090924208 no 510 0.155618828568859 734 17015229
SGTC_1239 0337-0584 35.4 µM 1.01245572775363 0.14247407198004 no 511 0.155660102271004 859 914301 YML130C ERO1
SGTC_846 0335-0850 148 µM 1.01013228711803 0.142999089646957 no 512 0.156215957613932 777 6819598
SGTC_3269 9137823 49.47 µM 1.00831878021862 0.143409787120185 no 513 0.156650725000099 719 17682936
SGTC_235 0330-0087 5 mM 1.00749421743364 0.143596785591564 no 514 0.156848667582411 816 46494818 YHR062C RPP1
SGTC_2241 6772625 37.8075 µM 1.00535613200698 0.144082437654066 no 515 0.15736269761876 747 2285411
SGTC_3125 9127534 49.47 µM 1.00395876598742 0.144400437972739 no 516 0.157699244514136 679 1639235
SGTC_3215 9129942 49.47 µM 1.00238712018881 0.144758664111186 no 517 0.15807833014527 755 17682944
SGTC_12 0849-0099 9.267 µM 1.00197116579062 0.144853572913308 no 518 0.158178759604617 791 6071388
SGTC_8 0354-0001 70 µM 1.00192267202452 0.144864640519219 no 519 0.158190470831078 894 4993152
SGTC_121 0557-0495 61.343 µM 0.997402928047034 0.145898669844921 no 520 0.159284485332609 1004 3104427
SGTC_2789 5281112 71.43 µM 0.996800789117266 0.146036800981356 no 521 0.159430607583695 772 765948
SGTC_1281 0884-0031 11.8 µM 0.996426232685671 0.146122768827393 no 522 0.159521546196877 824 1548255
SGTC_2370 9071495 200 µM 0.996363202797343 0.14613723872998 no 523 0.159536852569941 755 21791103
SGTC_1783 st039459 87.517 µM 0.993031867284063 0.146903390231529 no 524 0.160347212434639 855 729761
SGTC_1152 3909-8331 15.9 µM 0.992117714749208 0.147114100272576 no 525 0.160570052997962 776 16001939
SGTC_326 k292-0812 17.5 µM 0.991507596974749 0.147254843702686 no 526 0.160718892313645 800 3579357
SGTC_2436 5633522 8.09 µM 0.991501280881949 0.147256301185944 no 527 0.16072043360673 829 5724242
SGTC_1716 st033144 30.6155 µM 0.991316319432033 0.147298986641343 no 528 0.160765573354641 847 674617
SGTC_1715 st032160 10.2275 µM 0.990698761497229 0.147441566898868 no 529 0.160916348010904 773 5289825
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.98736047135489 0.148213903775007 no 530 0.161732977660678 902 551469
SGTC_2525 harmine 47.85 µM 0.98641599831335 0.14843290460428 no 531 0.1619645088093 778 5280953 A monoamine oxidase inhibitor
SGTC_896 0964-0007 44.5 µM 0.983308051753124 0.149155090609277 no 532 0.16272792425097 833 6756758
SGTC_151 3013-0144 2.285 µM 0.981404931740709 0.14959847051924 no 533 0.163196547553699 821 906558 YHR107C CDC12
SGTC_3299 9121982 43.1275 µM 0.980880067090681 0.149720905572506 no 534 0.163325944086097 818 17594604 YPL160W CDC60
SGTC_1296 1068-0102 11.9 µM 0.980798756466732 0.149739878861142 no 535 0.163345995810894 828 767053
SGTC_2862 9027634 71.43 µM 0.975649384219764 0.15094471788133 no 536 0.16461912152226 741 5012562
SGTC_2366 9070441 60.58 µM 0.974934007985543 0.151112609111537 no 537 0.164796497762123 835 6837235
SGTC_2268 7933382 153.85 µM 0.973980263189154 0.151336636096191 no 538 0.165033169530337 925 935025 YOR257W CDC31
SGTC_2716 st080858 38.6235 µM 0.973312963351204 0.151493510734419 no 539 0.165198890766931 874 5296050
SGTC_2151 5563267 85.4165 µM 0.9728880539214 0.151593458452956 no 540 0.165304471426483 851 5310824
SGTC_2097 5376186 200 µM 0.971860386574871 0.151835368797759 no 541 0.165560004654739 830 742755
SGTC_2774 tamoxifen 10.92 µM 0.969204015517076 0.152461859737551 no 542 0.166221703991984 832 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_298 1391-0729 10 µM 0.968856192698693 0.152544018728856 no 543 0.166308472609132 817 3237558
SGTC_2176 5809774 33.9695 µM 0.96452718246693 0.153569029102702 no 544 0.167390843536632 873 2870539
SGTC_1555 citronellol 128 µM 0.962734184391454 0.153994902616211 no 545 0.167840468495465 803 8842 A terpine precursor.
SGTC_2146 5545642 200 µM 0.9625007289183 0.154050410481849 no 546 0.167899068609847 839 825326
SGTC_2391 6285546 200 µM 0.961813401843717 0.154213910607569 no 547 0.168071672380762 851 846083
SGTC_3293 9120939 62.045 µM 0.961559620148636 0.154274308740717 no 548 0.168135431704188 814 934087
SGTC_1449 4112-4002 201 µM 0.961039392962461 0.154398167789454 no 549 0.168266180606546 784 2059539
SGTC_1630 st005209 31.3 µM 0.958368924961757 0.155035004747905 no 550 0.16893837960421 912 3367314
SGTC_1954 st077032 68.9 µM 0.955162355637309 0.155801976460277 no 551 0.16974779971903 748 698907
SGTC_2743 auranofin 4.32 µM 0.953392389037807 0.156226400337768 no 552 0.170195648108378 824 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1246 0422-0085 105 µM 0.952937798785188 0.156335530278035 no 553 0.170310793555568 877 264295
SGTC_185 k048-0037 25.491 µM 0.952578928503746 0.15642171692705 no 554 0.170401728850301 878 6827589
SGTC_1271 0832-2808 169 µM 0.952561139826973 0.156425989887416 no 555 0.170406237189109 897 3663794
SGTC_503 tyrphostin 8 294 µM 0.951730784904079 0.15662553228914 no 556 0.170616766255166 850 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2125 5246583 200 µM 0.951028789494882 0.156794359299664 no 557 0.170794880751173 937 835267
SGTC_338 4055-0136 114 µM 0.950196651904003 0.156994640028146 no 558 0.171006169778187 846 2900563
SGTC_1620 st003704 16.5 µM 0.949180343694339 0.157239475529423 no 559 0.171264448489759 870 2834414
SGTC_1949 st076024 69.1 µM 0.944524430962053 0.158364324124519 no 560 0.172450861667164 858 2921930
SGTC_2866 9034245 58.44 µM 0.943039890970425 0.158724089899328 no 561 0.172830249620981 859 6462273
SGTC_3049 9092223 49.47 µM 0.942883048100969 0.158762130719569 no 562 0.172870363315004 827 8623917
SGTC_2685 mycophenolic acid 18.85 µM 0.94096372269448 0.159228129778096 no 563 0.173361725090443 861 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3117 9124945 49.47 µM 0.938013560748435 0.159946153854156 no 564 0.174118720595108 768 17592065
SGTC_1116 jasmonic acid 1.58368 µM 0.934857012954962 0.160716750434807 no 565 0.17493099655251 877 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_327 1273-0057 3.96 µM 0.932129098863244 0.161384655925976 no 566 0.175634905710841 843 3108138
SGTC_1323 1348-1351 11.2 µM 0.931409500914035 0.161561144387456 no 567 0.175820889051251 837 6989654
SGTC_1924 st058459 75.1 µM 0.930968082456257 0.16166946884061 no 568 0.175935037352626 865 688683
SGTC_2628 lathosterol 100 µM 0.930873568974811 0.161692668678578 no 569 0.175959484099626 877 6710616
SGTC_2729 fluphenazine 10.66 µM 0.928096001627943 0.162375435606613 no 570 0.176678886745052 898 3372 An atypical antipsychotic.
SGTC_1210 3013-0140 750 nM 0.927157978856741 0.16260643866969 no 571 0.176922258412425 938 905973
SGTC_3044 9093193 49.47 µM 0.926984223535618 0.162649252146724 no 572 0.176967362783544 892 25236277
SGTC_1193 1488-0126 41.5 µM 0.926272177091322 0.162824777663178 no 573 0.177152275644646 895 1384710
SGTC_1285 0929-0069 65.5 µM 0.925827628622885 0.16293442508519 no 574 0.177267783246382 869 1206237
SGTC_1041 0206-0046 107 µM 0.925669678867221 0.162973394785698 no 575 0.177308834983906 876 50494
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.925405930386664 0.163038480878889 no 576 0.177377397589375 716 4000243
SGTC_1570 verbenone 133 µM 0.925041817895137 0.163128361894198 no 577 0.177472077772606 906 29025 A natural terpanoid with antifungal properties.
SGTC_394 menadione 8.33 µM 0.924791716692099 0.163190117924037 no 578 0.17753713007518 888 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3142 9086498 49.47 µM 0.92468818355662 0.163215687202458 no 579 0.177564063853273 826 25236367
SGTC_1199 1638-0010 4.46 µM 0.921188065108196 0.164081632807794 no 580 0.178476124138208 861 3111136
SGTC_2529 gangaleoidin 93.61 µM 0.91997591790551 0.164382217170633 no 581 0.178792672005472 889 4565183
SGTC_389 tpck 16.7 µM 0.91972593223016 0.164444252188244 no 582 0.178857998796083 879 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2160 5660466 132.927 µM 0.918832268902911 0.164666142649768 no 583 0.179091655635802 847 2859134
SGTC_3081 9117243 49.47 µM 0.914318509815568 0.165789840787563 no 584 0.180274753628628 899 45595589
SGTC_650 1328-0195 38 µM 0.913892412809116 0.165896172905636 no 585 0.180386690392479 909 2780821
SGTC_1181 1222-0449 220 µM 0.912634827084667 0.166210259235795 no 586 0.180717315559007 902 658318
SGTC_992 3909-8734 162 µM 0.912579688554982 0.166224039055802 no 587 0.180731820425355 873 4288319
SGTC_253 dyclonine 31.25 µM 0.911843229368867 0.166408160319697 no 588 0.18092562502021 959 3180 An oral anasthetic.
SGTC_77 0828-0286 12.516 µM 0.910494696803507 0.166745646484835 no 589 0.181280838622776 916 745345
SGTC_3306 9127676 59.7925 µM 0.908919723906547 0.167140360689205 no 590 0.181696250784236 873 41905287
SGTC_3333 9141820 12.094 µM 0.907935042750199 0.16738744382965 no 591 0.181956270951388 858 1939433
SGTC_495 decylubiquinone 155 µM 0.907581899674546 0.167476114295478 no 592 0.182049580461501 837 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2274 7947094 46.08 µM 0.907123161777489 0.167591343677347 no 593 0.182170835511003 974 2971028
SGTC_1763 st044482 94.5 µM 0.905898056713446 0.167899325409423 no 594 0.182494906501796 920 88505
SGTC_2377 9073351 62.6 µM 0.905039040389448 0.168115492481199 no 595 0.182722352477405 861 7337946 YHR072W ERG7
SGTC_232 clozapine 119 µM 0.904258840087451 0.168311981019944 no 596 0.182929083242259 895 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1427 4048-4900 550 nM 0.904204544153924 0.168325660604547 no 597 0.18294347554203 934 24132586
SGTC_1248 0469-0687 58.6 µM 0.90290551195906 0.16865315836982 no 598 0.183288022507394 908 4017482
SGTC_1552 6-methylflavone 10.6 µM 0.902425891827955 0.168774178394548 no 599 0.183415336087441 879 689013
SGTC_1917 st066507 28.5 µM 0.902384985552942 0.168784502641768 no 600 0.183426197073998 910 3156428
SGTC_4 0960-0234 25.671 µM 0.901880260279431 0.168911922567654 no 601 0.183560239196629 864 6821112
SGTC_1984 st072354 53.1 µM 0.901257000065225 0.169069352362189 no 602 0.183725845379461 904 5762938
SGTC_2345 9052315 157.45 µM 0.899520592920362 0.169508449611611 no 603 0.184187716018024 877 6469265
SGTC_80 0159-0065 512.242 µM 0.899510245852418 0.169511068337249 no 604 0.184190470420856 846 1548079
SGTC_3212 9128307 49.47 µM 0.899056939753226 0.169625820453372 no 605 0.184311166251933 782 27243542
SGTC_33 0986-0033 35.816 µM 0.898293975117718 0.169819073534089 no 606 0.184514421862877 887 2848082
SGTC_2644 guaiazulene 100 µM 0.896514300737562 0.170270399881068 no 607 0.184989072978994 944 3515 A coloring agent.
SGTC_83 0170-0301 39.027 µM 0.896035799741235 0.170391878945545 no 608 0.185116821707386 860 3089716
SGTC_3312 9133330 71.43 µM 0.895447213830673 0.170541381847696 no 609 0.185274035708047 966 17617324
SGTC_1207 2099-0101 141 µM 0.893528537211634 0.171029315438367 no 610 0.185787098440338 979 5837381
SGTC_1194 1488-0194 225 µM 0.893059545425523 0.171148719184759 no 611 0.18591264285498 925 1391452
SGTC_1274 0865-0114 173 µM 0.891010373341788 0.171671056714375 no 612 0.186461802601054 910 870624
SGTC_1160 4092-0570 10.5 µM 0.890328352923612 0.171845130546613 no 613 0.186644800578696 910 4994975
SGTC_1314 1222-0010 41.1 µM 0.889680381801605 0.172010618269724 no 614 0.186818765505143 930 3526027
SGTC_1302 1159-0335 255 µM 0.889413709652046 0.172078754189383 no 615 0.186890389811637 890 649284
SGTC_1009 4106-0057 9.87 µM 0.886231868345802 0.172893057508588 no 616 0.187746297098429 984 2928005
SGTC_834 0312-0008 75.7 µM 0.886104267406952 0.172925764530849 no 617 0.187780671848078 932 6385573 YIL048W NEO1
SGTC_2038 4100038 30.985 µM 0.884310435331874 0.173385981721656 no 618 0.188264328300154 903 3596803
SGTC_763 3453-1109 128 µM 0.882408970162449 0.17387466320537 no 619 0.188777843310951 963 1560353
SGTC_618 k072-0232 33.2 µM 0.882307746046715 0.173900702598229 no 620 0.188805204357878 903 5872756 YGL099W LSG1
SGTC_2474 5321570 43.32 µM 0.881731274554764 0.174049044252304 no 621 0.188961072147223 936 2841384
SGTC_771 0250-0039 27.3 µM 0.880843691831104 0.174277600441464 no 622 0.189201213896795 901 3005115
SGTC_1238 0333-0287 48.8 µM 0.879448483436413 0.174637257638569 no 623 0.189579076993015 923 7226
SGTC_1291 0993-0025 5.79 µM 0.878806854149568 0.174802815097298 no 624 0.189753004647854 951 4353356
SGTC_2112 5488546 200 µM 0.878520443612013 0.174876748799382 no 625 0.189830674159094 918 600757
SGTC_73 0327-0325 16.231 µM 0.876099598359583 0.175502455719142 no 626 0.190487945550637 1020 53298
SGTC_2063 5246145 200 µM 0.875421570999403 0.175677957000345 no 627 0.190672283508954 962 711240
SGTC_623 k072-0108 16.9 µM 0.8747825058182 0.175843475029475 no 628 0.190846128861959 926 5382803
SGTC_2201 6605497 169.863 µM 0.871689943765412 0.176645844170243 no 629 0.191688773891806 951 670741
SGTC_2336 9001819 198.65 µM 0.871136638014355 0.176789643822627 no 630 0.19183977567499 974 2989602
SGTC_2873 9040596 71.43 µM 0.869298885855923 0.17726779148244 no 631 0.192341836062748 935 6463863
SGTC_3237 9133362 49.47 µM 0.868727841530276 0.177416532353092 no 632 0.192498004661531 938 43845137
SGTC_694 1315-0438 43.2 µM 0.868275733744182 0.177534349491511 no 633 0.192621701584403 890 6793154
SGTC_1961 st076550 68.7 µM 0.867884749897453 0.177636277830612 no 634 0.192728714128113 883 1579337
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.866553385096784 0.177983637611419 no 635 0.193093381946996 925 6708514
SGTC_2524 avocatin b 10.57 µM 0.86570655228917 0.178204803259525 no 636 0.193325552949416 922 6710748
SGTC_281 1672-3440 14.9 µM 0.864242885832147 0.178587474352744 no 637 0.193727238934069 1002 6833000
SGTC_2513 baicalein 25.65 µM 0.863717557313324 0.178724945987075 no 638 0.19387153314826 958 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3219 9131112 49.47 µM 0.862647989208419 0.179005043884741 no 639 0.194165518343667 913 17612988 YMR079W SEC14
SGTC_2351 9026858 72.31 µM 0.861540727231398 0.179295303847484 no 640 0.194470150094277 898 1409300
SGTC_3217 9129673 49.47 µM 0.859274955933003 0.179890179726089 no 641 0.195094418924562 912 17248312
SGTC_975 1335-0046 28.5 µM 0.858927087178694 0.179981621950456 no 642 0.195190372016721 968 16486740
SGTC_3012 9080433 71.4286 µM 0.857919876167343 0.180246546179321 no 643 0.195468354036358 1010 17688859
SGTC_1649 st011737 51.3 µM 0.856878366511407 0.180520749131014 no 644 0.1957560549252 937 1761035
SGTC_2081 5214970 32.255 µM 0.856790969172273 0.180543770516079 no 645 0.195780208767774 980 2063512
SGTC_1683 st010134 710 nM 0.854854578009904 0.181054308749866 no 646 0.196315829546984 950 3818134
SGTC_1005 4092-0690 4.4 µM 0.852438651899419 0.181692545398695 no 647 0.196985337540362 912 1529343
SGTC_2246 7293507 91.5585 µM 0.850751049025239 0.182139208479582 no 648 0.197453829492167 1015 887656
SGTC_3074 9116018 49.47 µM 0.849498504832044 0.182471166610956 no 649 0.197801980911032 951 17027303
SGTC_2697 mebhydrolin 72.4 µM 0.84836210406226 0.182772670354523 no 650 0.198118170325925 988 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2879 9041815 71.43 µM 0.847056156780016 0.183119541084159 no 651 0.198481910572688 904 4942971
SGTC_1226 3909-7979 35.4 µM 0.846457863873632 0.18327858984819 no 652 0.198648685170886 1004 6615510
SGTC_2093 5331342 194.4 µM 0.845304321998397 0.183585487751938 no 653 0.198970474289238 988 33839
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.843527133414652 0.184058932175971 no 654 0.199466848657001 1023 3256 An antibiotic and ribosome inhibitor.
SGTC_3236 9132701 49.47 µM 0.840718076486781 0.184808815765144 no 655 0.200252945679756 964 24282524
SGTC_511 blebbistatin 171 µM 0.840651433609965 0.1848266292492 no 656 0.200271617850212 979 3476986 A myosin inhibitor.
SGTC_225 nsc-122657 1.016 µM 0.838850027633876 0.185308545065365 no 657 0.200776736584457 870 275685
SGTC_2587 piperic acid 92.2 µM 0.838375799291894 0.185435541217628 no 658 0.200909838430452 911 5370536
SGTC_833 3852-0053 558 µM 0.838085502697561 0.185513307951441 no 659 0.200991342201772 1030 3123681
SGTC_1807 st050092 58.9 µM 0.838033250010387 0.185527307925314 no 660 0.201006014790289 945 5008496
SGTC_2678 equilin 100 µM 0.836752561569972 0.185870645562377 no 661 0.201365833767335 1030 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_941 3237-0776 460 µM 0.835732925468123 0.186144279665107 no 662 0.201652584000878 965 760008
SGTC_2387 9077560 195.08 µM 0.830528402086724 0.18754487514553 no 663 0.203120048232279 960 5303272
SGTC_529 4076-0302 30.3 µM 0.830080955375407 0.187665591305753 no 664 0.203246506959033 936 5816522
SGTC_1508 1080-0625 72.9 µM 0.829062373397094 0.187940572387412 no 665 0.203534556822397 946 767111
SGTC_1077 5-fluorocytosine 377 nM 0.827193876215701 0.188445646818738 no 666 0.204063591014951 961 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2061 5245884 80.95 µM 0.825638614152684 0.188866688253257 no 667 0.204504561907234 1015 573863
SGTC_2915 7971052 15.16 µM 0.823700821518731 0.189392098911096 no 668 0.205054786272387 870 5741558
SGTC_1974 st069448 26.9 µM 0.823594709207637 0.189420896025984 no 669 0.205084941603216 1021 6323587 YNR016C ACC1
SGTC_2317 5986382 200 µM 0.821426308545545 0.190009953919035 no 670 0.205701741581806 1033 877883
SGTC_865 0488-0499 301 µM 0.821209427985602 0.190068932585284 no 671 0.205763493604601 1062 9634651
SGTC_3330 9141424 71.43 µM 0.820639221904052 0.190224048532772 no 672 0.20592589985762 1039 27261020
SGTC_1093 fluphenazine 7.97 µM 0.82038423901066 0.190293437933783 no 673 0.205998548752198 1054 6602611 An atypical antipsychotic.
SGTC_822 1487-0950 154 µM 0.820353825048827 0.190301715631088 no 674 0.206007215213613 1021 1958375
SGTC_2007 4011539 71.82 µM 0.820012521960896 0.19039462246668 no 675 0.206104484390003 986 45595301
SGTC_1618 st003135 44.5 µM 0.819366369476228 0.190570589274625 no 676 0.20628870823879 995 1270615
SGTC_3194 9111903 49.47 µM 0.818230306372633 0.190880215510034 no 677 0.206612846525852 996 17087251
SGTC_2625 euphol 100 µM 0.817966282946444 0.190952217463437 no 678 0.206688220111506 1017 6708538 A triterpene alcohol.
SGTC_2408 sulbentine 18.36 µM 0.816776601274751 0.191276862730729 no 679 0.207028053158098 973 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_275 trichlorophene 5.69 µM 0.815838882032302 0.191532989724274 no 680 0.207296145874966 1090 62616
SGTC_651 3253-0966 34.4 µM 0.815527343984679 0.191618129157715 no 681 0.207385259609414 1030 781462
SGTC_1829 berberine 14.4 µM 0.814863638966596 0.19179958868064 no 682 0.207575184259854 1013 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2054 5233173 129 µM 0.81409993223393 0.192008519195469 no 683 0.207793852353655 1010 6889
SGTC_828 2074-0507 139 µM 0.813401062019038 0.192199834104404 no 684 0.207994075319855 1045 X828
SGTC_1475 4092-1048 11.7 µM 0.808851412052121 0.193448143919546 no 685 0.209300309838908 1042 2881759
SGTC_1502 4534-4282 27.7 µM 0.805765896186097 0.194297540020965 no 686 0.210188922853893 990 3278949
SGTC_1293 1000-1278 195 µM 0.805192731563825 0.194455573366039 no 687 0.210354235081417 1050 678847
SGTC_187 1488-2104 32.728 µM 0.804903943358551 0.19453522788316 no 688 0.2104375563314 1083 2852859
SGTC_584 0986-0246 15.4 µM 0.803165882099451 0.195015044959022 no 689 0.210939431240686 1154 53315 YDR232W HEM1
SGTC_933 2914-0560 114 µM 0.802463232491499 0.195209225653031 no 690 0.211142524280118 1095 463887
SGTC_848 0368-0089 85.6 µM 0.80241935679072 0.195221354816225 no 691 0.211155209862523 1036 762535
SGTC_383 2324-0395 7.37 µM 0.801622016642859 0.195441854290568 no 692 0.211385819001743 1057 3146421
SGTC_115 0527-0192 112.043 µM 0.801485827798497 0.195479531590743 no 693 0.211425222697209 1072 4233931
SGTC_2368 9071271 200 µM 0.797987669961371 0.196448825076327 no 694 0.212438822694096 1023 27209959
SGTC_991 3996-0057 64.7 µM 0.797675648941443 0.196535423254963 no 695 0.212529369267721 991 715343
SGTC_2449 5812982 45.77 µM 0.797188991835045 0.196670536020299 no 696 0.212670639146078 992 776185
SGTC_255 tunicamycin 200.472 nM 0.794409044322064 0.197443423264506 no 697 0.213478670317614 1037 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1439 4092-1168 46 µM 0.794367663479546 0.197454941914995 no 698 0.213490711746017 1058 2886240
SGTC_1786 berberine 21.6 µM 0.79426808203538 0.197482662780429 no 699 0.213519690613847 995 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1872 amphotericin b 148 nM 0.793699048135282 0.197641112047905 no 700 0.213685327261833 1077 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1004 4084-0029 199 µM 0.79322073247557 0.197774359961747 no 701 0.213824615167527 1077 716894 YLR208W SEC13
SGTC_1411 3909-8223 150 µM 0.792599967199771 0.197947372029268 no 702 0.214005463923952 1107 X1411
SGTC_199 4063-0024 41.6 µM 0.791976895196143 0.198121118895339 no 703 0.214187074203395 1077 306215
SGTC_2882 9058044 58.44 µM 0.791180570806273 0.198343312084958 no 704 0.21441931381317 1052 18076804
SGTC_2703 st077852 53.4 µM 0.78876933597233 0.199017019665586 no 705 0.215123417365504 1016 6281836
SGTC_2472 5377652 49.4 µM 0.787227076910659 0.199448654462581 no 706 0.215574474667222 1043 1610903
SGTC_56 0957-0365 83.25 µM 0.786073125671183 0.199771981129121 no 707 0.215912323801451 1038 6752360
SGTC_3129 9127257 49.47 µM 0.784270796297102 0.200277607819552 no 708 0.216440615776917 980 837894
SGTC_1509 1326-1131 80 µM 0.783826190826115 0.200402455876891 no 709 0.216571051785442 1030 768313
SGTC_772 k072-0172 35.3 µM 0.782764195313271 0.200700860144817 no 710 0.21688279840638 1024 5861980
SGTC_2424 5537928 59.2 µM 0.78226370439601 0.200841582752339 no 711 0.217029806386693 1120 5382802
SGTC_3289 9119912 71.43 µM 0.779869663475 0.201515531809389 no 712 0.217733798230383 1066 17014829
SGTC_2395 5646831 180.19 µM 0.779026942307601 0.201753089238167 no 713 0.217981922018621 1039 6808628
SGTC_219 mitoxanthrone 164.414 µM 0.778539668556398 0.201890524919611 no 714 0.218125465188752 1034 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2365 9042475 200 µM 0.776752760059092 0.20239500234358 no 715 0.218652326267499 1097 6464479
SGTC_1047 2043-3044 82 µM 0.772146946071851 0.203698779929596 no 716 0.220013699937257 1129 669592
SGTC_1399 3562-5772 25 µM 0.771698789833024 0.203825907240544 no 717 0.220146423823288 1002 23847490
SGTC_2221 6807166 181.081 µM 0.770043020440292 0.204296004978803 no 718 0.220637186917039 1041 674925
SGTC_427 1354-0053 47.3 µM 0.769221839906394 0.204529389712009 no 719 0.220880813680679 1059 6813657
SGTC_459 nigericin 15.3 µM 0.768409032640921 0.204760550878739 no 720 0.22112210786807 1159 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1934 st074720 32.6 µM 0.768102964790683 0.204847636373992 no 721 0.221213007834837 1143 17250992
SGTC_60 0986-0278 202 µM 0.767631818894533 0.204981734569537 no 722 0.221352976573387 953 3110598
SGTC_2999 9069765 71.4286 µM 0.766957196985734 0.205173837220422 no 723 0.221553482424086 1108 2097066
SGTC_3058 9093861 49.47 µM 0.766668181967913 0.205256168708566 no 724 0.221639412961598 1070 17217477
SGTC_968 1309-0633 340 µM 0.766506451864358 0.205302249203676 no 725 0.221687507197179 1079 3761976
SGTC_1507 4075-3230 155 µM 0.76603392157197 0.205436918771888 no 726 0.221828059308513 1018 659771
SGTC_3106 9121286 49.47 µM 0.765382301481096 0.205622714365134 no 727 0.222021964379179 1087 15943471
SGTC_2566 crystal violet carbinol 226 nM 0.764059768185281 0.206000113090565 no 728 0.222415813008451 1040 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_223 busulfan 5 mM 0.763998640371442 0.206017566479425 no 729 0.222434026418436 1028 2478 A DNA alkylator.
SGTC_1011 4112-3381 17.4 µM 0.763473578372055 0.206167519803785 no 730 0.222590506916518 1095 2877139
SGTC_3103 9120822 49.47 µM 0.762546990829727 0.206432303269903 no 731 0.222866804264357 1131 17141819
SGTC_190 3970-0790 3.722 µM 0.761451757570747 0.206745538955176 no 732 0.223193641587432 1075 2832352
SGTC_3175 9106517 49.47 µM 0.760076954352784 0.20713912944828 no 733 0.223604293577625 1077 41468073
SGTC_1340 1486-1359 257 µM 0.758469088409977 0.207600004993583 no 734 0.224085105768376 1086 4309068
SGTC_2839 9003951 25.97 µM 0.758423342190772 0.207613126459068 no 735 0.224098794189253 1102 2990634
SGTC_97 0535-0701 19.132 µM 0.758102741745941 0.207705098577982 no 736 0.224194739243137 1072 2832013 YGL099W LSG1
SGTC_2997 9067075 71.4286 µM 0.755276397480718 0.208516945764398 no 737 0.225041578712887 1106 27209819
SGTC_2820 7989630 71.43 µM 0.752555560582553 0.209300251508902 no 738 0.225858515301603 1002 2984098
SGTC_3112 9123419 49.47 µM 0.751635218132039 0.209565601737571 no 739 0.226135229042016 1163 17015854
SGTC_1260 0700-1617 7.75 µM 0.751619678724102 0.209570083708646 no 740 0.226139902824984 1098 2853078
SGTC_3176 9106582 49.47 µM 0.750920404908818 0.209771830888223 no 741 0.226350279688362 1017 17018027
SGTC_451 chloral hydrate 100 µM 0.749380409290071 0.210216536763453 no 742 0.226813977678684 1161 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2921 7974240 10.71 µM 0.749226755193595 0.210260937948448 no 743 0.226860272841763 1104 2979074 YDR527W RBA50
SGTC_2938 9059746 27.26 µM 0.747462506605784 0.210771144636999 no 744 0.227392213381599 1053 6471769
SGTC_2886 9058944 51.95 µM 0.746817964922227 0.21095772193133 no 745 0.227586724959796 991 4949929
SGTC_3328 9140624 29.0385 µM 0.745030346577641 0.211475695272504 no 746 0.228126687336199 1130 4904392
SGTC_1811 st050069 61.5 µM 0.743970285757128 0.211783205812679 no 747 0.228447225917901 1122 3877702
SGTC_2845 9003024 42.97 µM 0.742356573934534 0.212251825646446 no 748 0.228935661581468 1144 2990173
SGTC_1127 asiatic acid 681.4 nM 0.741763552138208 0.212424190587247 no 749 0.229115303593046 1079 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2380 9035439 200 µM 0.740498195632165 0.212792246490729 no 750 0.229498877812931 1184 6462575
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.740390275524198 0.212823654573507 no 751 0.229531608852367 1175 6728940
SGTC_2016 5121758 140 µM 0.739634287951762 0.213043746152189 no 752 0.229760965293497 1165 2795203
SGTC_1668 st014914 51.6 µM 0.738935337284495 0.213247350596716 no 753 0.229973131636555 1145 2839556
SGTC_2787 5284540 71.43 µM 0.737053990813161 0.213795950556023 no 754 0.230544758444724 1114 736958
SGTC_1371 2421-0008 32.7 µM 0.735360152545123 0.214290575578689 no 755 0.231060091490816 1093 2827552
SGTC_817 1391-0715 46 µM 0.735135127052047 0.214356336296424 no 756 0.231128601552355 1095 1353946
SGTC_2186 6124449 200 µM 0.734243193454532 0.21461710750014 no 757 0.231400266380776 1105 3834182 YLR033W RSC58
SGTC_1903 st060211 78.3 µM 0.732447370366566 0.21514270440337 no 758 0.231947777348623 1156 688960
SGTC_2592 piperlongumine 83.33 µM 0.730333275162217 0.215762408942397 no 759 0.232593246667686 1104 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_317 4495-0002 170 µM 0.729560937382312 0.215989062036632 no 760 0.2328293033745 1101 15991618
SGTC_2132 5317594 122.667 µM 0.72870270894122 0.216241082645188 no 761 0.233091767696619 1102 794577
SGTC_900 1112-0045 141 µM 0.726486497998796 0.216892664638332 no 762 0.233770290882496 1053 56211 YIL048W NEO1
SGTC_1117 retinoic acid 1.10837 µM 0.726250930582999 0.216961989825246 no 763 0.233842477368238 1162 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_3026 9090633 49.47 µM 0.72618327656159 0.21698190210917 no 764 0.233863211321757 1156 25236842
SGTC_86 0417-1630 471.922 µM 0.725577232005205 0.21716032340232 no 765 0.234048991455254 1207 3634867
SGTC_2324 6149169 200 µM 0.725568342975496 0.217162940989251 no 766 0.234051716953983 1090 2888231
SGTC_1919 st067113 52.3 µM 0.724306299201622 0.217534764862214 no 767 0.234438855296814 1126 1268243
SGTC_639 0833-0042 114 µM 0.72242688090729 0.218089160367044 no 768 0.235016032525548 1150 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_617 3770-0098 35 µM 0.720723730303648 0.218592262670698 no 769 0.235539754551689 1120 5962639
SGTC_2745 rifampicin 24.3 µM 0.719774606523949 0.218872918843328 no 770 0.235831891074902 1076 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_728 3030-5151 22.5 µM 0.71835125782762 0.219294191778062 no 771 0.236270366289465 1144 3125388
SGTC_3033 9090887 49.47 µM 0.716409999623496 0.219869502534064 no 772 0.236869111115858 1181 19325384
SGTC_1960 st011366 51.8 µM 0.715603107570805 0.220108887466309 no 773 0.237118227117193 1203 3972846
SGTC_1276 0871-0068 94.2 µM 0.714534285970654 0.22042621047265 no 774 0.237448431510137 1133 3414906
SGTC_2035 5154463 94.595 µM 0.713591767400002 0.220706252732178 no 775 0.237739824858889 1149 2769623
SGTC_2334 9017922 200 µM 0.713407436201934 0.220761045255085 no 776 0.237796836458796 1175 3163164
SGTC_218 alverine citrate 93.75 µM 0.713017365681789 0.220877019555299 no 777 0.237917505673941 1141 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1177 0983-0204 23.6 µM 0.712889579791202 0.22091501995961 no 778 0.237957043833599 1198 766818
SGTC_1809 st050081 57.6 µM 0.712837993043761 0.220930361659293 no 779 0.237973006280338 1216 5036894
SGTC_54 0159-0055 9 µM 0.712360777440517 0.221072312652952 no 780 0.238120698558466 1182 3319099
SGTC_2887 9044784 58.44 µM 0.710669439899128 0.221575832470077 no 781 0.238644550700342 1199 6465546
SGTC_1979 st071809 45.3 µM 0.710571783040121 0.221604925417083 no 782 0.238674816868778 1191 4976333
SGTC_354 2783-3500 4.88 µM 0.709085869028182 0.22204786317596 no 783 0.239135595759455 1155 6740761
SGTC_2469 5655019 90.81 µM 0.708978374995452 0.222079925783659 no 784 0.239168948286004 1209 2788239
SGTC_874 0599-0792 117 µM 0.704386554455507 0.223452009055389 no 785 0.240596038493467 1215 765305
SGTC_2298 7976326 193.81 µM 0.703315836753473 0.223772642535318 no 786 0.24092947172569 1079 2235818
SGTC_3189 9110682 49.47 µM 0.701821300871488 0.22422062816738 no 787 0.241395306548368 1205 17122418
SGTC_740 k014-0057 261 µM 0.700982093030795 0.224472402973 no 788 0.241657095246251 1197 4012779
SGTC_2315 7733312 200 µM 0.70073248172198 0.224547321014023 no 789 0.241734990571393 1173 726316
SGTC_1994 st072947 40.9 µM 0.696539826664436 0.225807817971341 no 790 0.243045412348203 1198 5286565 YDL195W SEC31
SGTC_1606 st000094 49.2 µM 0.696471512594145 0.225828389273241 no 791 0.243066795795786 1225 1242210
SGTC_15 0266-0086 27.098 µM 0.695846026665677 0.226016790078179 no 792 0.243262630660146 1283 1712902 YIL048W NEO1
SGTC_1476 4112-3294 3.34 µM 0.695002079049212 0.226271133856952 no 793 0.24352699932101 1215 704369
SGTC_3173 9105693 49.47 µM 0.694922517675883 0.226295119915199 no 794 0.243551930118445 1247 17096658
SGTC_1654 st012436 41.8 µM 0.693994847189254 0.226574898781886 no 795 0.243842720191411 1170 4323132
SGTC_1501 4491-0275 38.4 µM 0.693527017500056 0.226716066944989 no 796 0.243989438380259 1181 5104718
SGTC_2821 7996764 71.43 µM 0.693163349317944 0.226825838528716 no 797 0.244103522897902 1272 2987135
SGTC_1102 cgs 12066b 26.1 µM 0.692533352566384 0.227016071121296 no 798 0.244301224078656 1161 6438352 A 5-HT1B full agonist.
SGTC_3297 9117502 71.43 µM 0.692140812586656 0.227134647205159 no 799 0.244424451861616 1204 7453720
SGTC_2091 4-phenylthiadiazole 200 µM 0.690790372221151 0.227542846550222 no 800 0.244848643406199 1202 270010
SGTC_38 0929-0051 58.268 µM 0.689891456102124 0.227814791939152 no 801 0.245131224590018 1207 1379719
SGTC_41 0478-0632 82.643 µM 0.689651666294031 0.227887365451557 no 802 0.245206633979954 1217 3750424
SGTC_2348 9022543 33.42 µM 0.689055043755479 0.228067992501537 no 803 0.245394314674327 1196 3162678 YDL140C RPO21
SGTC_1792 st045773 43.6 µM 0.688253770590094 0.228310704014288 no 804 0.245646494121448 1160 2919270
SGTC_1676 st018489 23.4 µM 0.68700730489898 0.228688556014398 no 805 0.246039062577703 1207 3696235
SGTC_1176 0848-0131 83.3 µM 0.685724861980361 0.229077680319142 no 806 0.246443312901104 1267 6769040
SGTC_2103 5378138 10 µM 0.68400525773276 0.229600032402261 no 807 0.246985922874603 1256 244142
SGTC_1382 3002-2117 298 µM 0.681667804100177 0.230311132990663 no 808 0.247724515048093 1258 1497314
SGTC_960 1222-0186 7.7 µM 0.681568693502868 0.230341311627853 no 809 0.247755858209902 1203 3126296
SGTC_153 4077-0274 519.67 µM 0.681349890521897 0.230407943772542 no 810 0.247825060902831 1304 3121976
SGTC_1600 coumarin 106 71.1 µM 0.681001543983982 0.230514048090946 no 811 0.247935256734196 1247 100336 A hepatotoxic, DNA x-linker.
SGTC_2913 7966556 36.57 µM 0.677338349298622 0.231631487896512 no 812 0.249095652226798 1165 2976516
SGTC_2518 prenyletin 46.28 µM 0.676988091647874 0.231738490197407 no 813 0.249206754980163 1161 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1408 3909-7976 48.8 µM 0.676296334547973 0.231949900090267 no 814 0.249426259757302 1258 24152374
SGTC_2595 hexamethylquercetagetin 100 µM 0.676207178761588 0.23197715505944 no 815 0.249454557682737 1161 386331
SGTC_1514 1189-1591 158 µM 0.672047431617418 0.233250772637131 no 816 0.250776750457621 1257 767698 YMR146C TIF34
SGTC_770 0389-1121 67.2 µM 0.671712899203744 0.23335336699173 no 817 0.250883243937623 1299 6753108
SGTC_1793 st048256 72.231 µM 0.671082081027757 0.233546894327516 no 818 0.251084120747037 1172 672022
SGTC_1728 st035614 33.7865 µM 0.670343324215707 0.233773649035756 no 819 0.251319477504371 1227 15945546
SGTC_2742 clothiapine 36.27 µM 0.670177668115447 0.233824512418273 no 820 0.251372269039275 1188 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2102 5377816 72.7585 µM 0.670054699572769 0.233862272892801 no 821 0.251411460629496 1258 1379702
SGTC_727 3032-0951 202 µM 0.668461451784763 0.234351823676914 no 822 0.251919540199059 1215 3652836
SGTC_2891 9063876 19.48 µM 0.66613513177634 0.2350676400784 no 823 0.252662365387538 1215 6472478
SGTC_274 sirtinol 40.1 µM 0.665629278241078 0.2352234526078 no 824 0.25282404377134 1235 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2242 6630449 61.2675 µM 0.665020091940553 0.23541116926587 no 825 0.25301882112361 1241 691249 YDR170C SEC7
SGTC_3014 9081533 49.47 µM 0.664609178200823 0.235537836247318 no 826 0.253150248644382 1254 21367265
SGTC_3298 9116858 71.43 µM 0.664572939550405 0.235549008864159 no 827 0.25316184101376 1263 2506942
SGTC_1496 4469-0713 57.4 µM 0.663334872576172 0.235930888723142 no 828 0.253558053475494 1223 746691
SGTC_2880 9042983 58.44 µM 0.662749644615011 0.236111520092285 no 829 0.25374545441609 1260 6464714
SGTC_1755 st041960 45.185 µM 0.660152890880453 0.236913929778529 no 830 0.254577859997109 1259 2257073
SGTC_2941 9056145 11.23 µM 0.659892492059445 0.236994476915211 no 831 0.254661411301856 1151 2119517
SGTC_1939 st074455 53.6 µM 0.659612031295881 0.237081246488937 no 832 0.254751415721509 1277 1644229
SGTC_1432 4049-0298 68.4 µM 0.657412334811452 0.23776239849211 no 833 0.255457911250139 1271 741646
SGTC_1149 3909-7961 23.3 µM 0.655769775350248 0.238271728206125 no 834 0.255986133143175 1230 735261
SGTC_1076 itraconazole 331 nM 0.65465101701198 0.238618977993764 no 835 0.256346234604286 1266 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_3271 9137798 49.47 µM 0.654333067393228 0.238717716434701 no 836 0.256448623112964 1198 6498326
SGTC_1230 0170-0365 3.77 µM 0.653516727248355 0.238971331126985 no 837 0.256711604610348 1341 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.649622376741924 0.240183225285565 no 838 0.257968087647 1234 77254
SGTC_2339 9000433 200 µM 0.647653644569553 0.240797153060591 no 839 0.258604496231825 1230 2988954
SGTC_3061 glucosamine 200 µM 0.647254992555569 0.240921572240999 no 840 0.258733462619091 1214 91431 and experimental redox chemotherapeutic
SGTC_3166 9102297 49.47 µM 0.644566140349015 0.241761674872052 no 841 0.259604191586013 1232 25237072
SGTC_3059 1327-0034 3 µM 0.644553489150613 0.241765631355706 no 842 0.259608291986856 1230 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2975 9084847 53.72 µM 0.643595734663365 0.242065257550366 no 843 0.259918808431053 1310 27211724
SGTC_1779 st039427 55 µM 0.643297821928895 0.24215849832236 no 844 0.26001543465682 1332 1124498
SGTC_692 k241-0027 77.8 µM 0.641984406184447 0.242569803430068 no 845 0.260441653992007 1345 3600480
SGTC_249 wiskostatin 11.211 µM 0.641315602849366 0.242779389041282 no 846 0.260658826963593 1284 2775510 A n-wasp and actin depolymerizer.
SGTC_2692 st077426 47.7 µM 0.640290610469867 0.243100785172574 no 847 0.26099184198129 1264 25238571
SGTC_680 0417-1641 114 µM 0.638055725051489 0.243802351824706 no 848 0.261718703090862 1267 2835990
SGTC_2010 4012422 159 µM 0.636703446723094 0.244227383919713 no 849 0.262159014028118 1286 952393
SGTC_168 3970-0862 530.542 µM 0.631034816791711 0.24601341940201 no 850 0.264008879801677 1298 3135186
SGTC_2085 5307070 144.047 µM 0.628938800675955 0.246675588881346 no 851 0.264694561416071 1258 2840351
SGTC_1540 guanosine 70.6 µM 0.628763062549554 0.246731151076475 no 852 0.264752092747149 1250 6802 Guanosine is a purine nucleoside
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.628174995636908 0.246917125806085 no 853 0.264944654238105 1325 4213774
SGTC_1261 0712-0010 12.7 µM 0.627795358099519 0.247037225089768 no 854 0.265069003684781 1317 2840123
SGTC_2805 7950783 58.44 µM 0.627622999611527 0.247091761441786 no 855 0.265125469115192 1318 1178958 YDL195W SEC31
SGTC_2964 9083345 53.42 µM 0.626730376929071 0.247374301283155 no 856 0.265417994108738 1262 17741579
SGTC_1229 0139-0193 12.2 µM 0.625957834528658 0.247618971715909 no 857 0.2656712992558 1345 3090752
SGTC_2453 5731132 22.18 µM 0.625870013476411 0.247646793534141 no 858 0.265700102228294 1364 1362040
SGTC_2691 st077356 60.2 µM 0.623358214146844 0.248443240964572 no 859 0.26652457535709 1351 2839272
SGTC_450 aminopyrene 156 nM 0.621997017126334 0.248875422262893 no 860 0.266971914701688 1299 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1883 5-benzylidenerhodanine 20 µM 0.618485572157309 0.24999215440275 no 861 0.268127652751126 1313 1273210
SGTC_477 mead ethanolamide 10 µM 0.618438306430626 0.250007204266251 no 862 0.268143226696038 1194 16061185
SGTC_446 go6976 132 µM 0.618098150029265 0.250115527525109 no 863 0.268255320850014 1287 3501 A protein kinase C inhibitor.
SGTC_496 calpeptin 138 µM 0.618019977119563 0.250140425310099 no 864 0.268281085055076 1269 73364 A calpain inhibitor.
SGTC_1622 st003707 19.4 µM 0.617759425215393 0.250223419627906 no 865 0.268366966664502 1350 10140899
SGTC_1704 st028805 70.8 µM 0.615643169246081 0.250898057109308 no 866 0.269065026525832 1306 2876101
SGTC_3119 9125183 49.47 µM 0.615103037916152 0.25107039870756 no 867 0.26924333797656 1190 22695334
SGTC_1647 st011722 22.4 µM 0.614369061158161 0.251304691586385 no 868 0.269485737820596 1325 2854783
SGTC_2953 9074162 66.49 µM 0.613804686154945 0.25148492443514 no 869 0.269672200115062 1332 16451992
SGTC_1251 0490-5699 265 µM 0.613415382025521 0.251609288293585 no 870 0.269800858882733 1354 3883818
SGTC_2677 mitomycin C 100 µM 0.612989005459996 0.251745532270107 no 871 0.269941804751795 1329 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_987 1497-1013 404 µM 0.612981212460892 0.251748022800354 no 872 0.26994438120023 1308 1676435
SGTC_2398 5228213 48.84 µM 0.612724697267592 0.251830008622542 no 873 0.27002919472234 1347 80771 YMR134W ERG29
SGTC_696 1560-0013 611 µM 0.612507943793136 0.251899297032448 no 874 0.270100871924304 1362 1650269
SGTC_752 1896-0090 130 µM 0.611240945436665 0.252304512767349 no 875 0.270520040069289 1329 772567
SGTC_887 0885-0007 9.62 µM 0.611193504110051 0.252319692286349 no 876 0.270535741658599 1372 5719458
SGTC_1825 st052143 62.6 µM 0.610392231273665 0.252576143508355 no 877 0.270801006570762 1363 674173
SGTC_1022 4477-0945 21.3 µM 0.610126714623591 0.252661153667719 no 878 0.270888935661593 1321 4648966
SGTC_196 k015-0023 18.111 µM 0.609094348725923 0.252991828216072 no 879 0.271230951611775 1321 5211998
SGTC_1689 st020265 53.493 µM 0.60850007371616 0.253182282185991 no 880 0.271427928544075 1373 5758320 YPR016C TIF6
SGTC_957 1187-1561 14.1 µM 0.607377179246072 0.253542354493003 no 881 0.271800314832703 1306 1538454
SGTC_1048 3161-0300 24.5 µM 0.606670819098585 0.25376899683481 no 882 0.272034695743832 1316 2165101
SGTC_2899 9053889 58.44 µM 0.605658540346181 0.254093981410826 no 883 0.272370760171056 1316 6470052
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.605466205643665 0.25415575370967 no 884 0.272434636296551 1452 16725076
SGTC_1899 st063254 59.6 µM 0.604731277068921 0.254391863865959 no 885 0.272678781349121 1268 3093813
SGTC_3086 9117350 49.47 µM 0.604155815667086 0.254576822296939 no 886 0.272870026786323 1266 2679265
SGTC_3277 9138724 49.47 µM 0.60277561900795 0.25502071673924 no 887 0.273328984121908 1298 15943418
SGTC_2194 5927483 104.545 µM 0.601355264822561 0.255477948934668 no 888 0.273801693870528 1344 760979
SGTC_2005 4024620 188 µM 0.600482855416584 0.25575900210834 no 889 0.274092241756959 1324 236743
SGTC_2032 5185112 25.99 µM 0.600249411943252 0.255834235023807 no 890 0.274170013773481 1277 5718189
SGTC_1224 0823-0416 294 µM 0.599019508990025 0.256230792233141 no 891 0.27457993754889 1401 3598164
SGTC_1178 0988-0033 191 µM 0.598350106828002 0.256446761954673 no 892 0.27480317471328 1357 5392207
SGTC_1447 4239-0816 81.9 µM 0.598129048027852 0.25651810314772 no 893 0.274876914676915 1284 1341554
SGTC_2158 5657123 3.6195 µM 0.598106273393635 0.256525453678087 no 894 0.27488451230786 1318 2858827
SGTC_2847 9005661 71.43 µM 0.598024856141248 0.256551732054885 no 895 0.274911673995917 1261 2991449
SGTC_217 ketoconazole 989 nM 0.594660642706128 0.257638796305132 no 896 0.276035167479418 1298 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1348 1493-0373 93.8 µM 0.590731152725266 0.258911537598624 no 897 0.27735028558726 1366 3010129
SGTC_3003 9075612 71.4286 µM 0.590117142705237 0.259110705663118 no 898 0.277556058329485 1358 6501993
SGTC_702 1488-0190 94 µM 0.589361371341739 0.259355965944795 no 899 0.277809441830883 1362 949357
SGTC_1259 0671-0132 43 µM 0.586889713495236 0.260158896431937 no 900 0.278638889375982 1333 X1259
SGTC_3165 9101544 49.47 µM 0.585802088333631 0.260512622454188 no 901 0.279004260101387 1374 5002184
SGTC_2794 7785382 27.27 µM 0.585011039159581 0.260770049167165 no 902 0.279270147035847 1340 2205081
SGTC_1020 4335-0961 93.3 µM 0.58474507930093 0.260856628388011 no 903 0.279359568941589 1303 669075
SGTC_1395 3486-0190 4.35 µM 0.584593631524778 0.260905936533877 no 904 0.279410495430155 1430 6748079
SGTC_1086 cerivastatin 2.18 µM 0.583872678822728 0.261140728969543 no 905 0.279652987933868 1349 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2791 5663188 71.43 µM 0.58318903693208 0.261363470673428 no 906 0.279883025252744 1412 54690634
SGTC_898 1000-0849 28.3 µM 0.581992788813182 0.261753462499068 no 907 0.280285769086582 1350 6751807
SGTC_593 1203-0218 61.7 µM 0.578074197993649 0.263033059484152 no 908 0.281607013090323 1426 3666956
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.578024846247793 0.263049195421363 no 909 0.281623672313106 1361 16623 A steroid.
SGTC_1935 st074532 41.6 µM 0.577019803416769 0.263377912010375 no 910 0.281963038885761 1432 2829742
SGTC_808 0711-0032 135 µM 0.576691428404009 0.263485358158914 no 911 0.282073961917148 1363 4252555
SGTC_2311 7694451 200 µM 0.576236541976692 0.263634236505679 no 912 0.282227654420595 1414 2163142
SGTC_589 1227-0070 34.1 µM 0.575288229608101 0.263944744608966 no 913 0.28254819030375 1377 2841384
SGTC_2301 7769476 200 µM 0.574633842261714 0.264159120808341 no 914 0.282769479584296 1432 977820
SGTC_132 0417-1715 25.805 µM 0.574463502843309 0.264214938261085 no 915 0.282827095647438 1445 6769098
SGTC_2797 7859098 81.82 µM 0.574201959659635 0.264300653392468 no 916 0.282915571691782 1390 972681
SGTC_2256 7954252 200 µM 0.573384550684594 0.264568632775619 no 917 0.283192174244841 1321 2972920
SGTC_946 3434-1334 87.4 µM 0.573043872662914 0.264680361466132 no 918 0.283307494376056 1404 4047976
SGTC_3105 9121040 49.47 µM 0.571830101941505 0.265078624403824 no 919 0.283718540924645 1262 41448907
SGTC_1562 morin hydrate 59.1 µM 0.571376778594541 0.265227447080899 no 920 0.283872133253272 1401 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1866 st057638 64 µM 0.570657641879606 0.265463621304879 no 921 0.284115868507036 1388 688802
SGTC_135 0933-0004 26.348 µM 0.569285312333655 0.265914608796489 no 922 0.284581266363352 1344 21230617 YGL099W LSG1
SGTC_977 1348-1378 135 µM 0.568706312514123 0.266105001394868 no 923 0.284777731600595 1355 X977
SGTC_1908 st060353 56.5 µM 0.567949292331261 0.266354036545845 no 924 0.285034700000521 1484 4227716
SGTC_2220 6782180 200 µM 0.567820063018713 0.266396560590554 no 925 0.285078577577107 1356 833803
SGTC_448 monastrol 171 µM 0.566931729756116 0.266688967414764 no 926 0.285380282875832 1381 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.566614964830483 0.266793274072404 no 927 0.285487902755896 1403 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1007 4101-0031 70 µM 0.56630404787769 0.266895675111979 no 928 0.285593554591848 1409 1146276
SGTC_423 5-fluorouracil 457 µM 0.566213356880513 0.266925548089867 no 929 0.28562437555562 1317 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2860 9025725 38.96 µM 0.565857412425764 0.267042810015754 no 930 0.285745357114443 1333 40546248
SGTC_1621 st003705 32.4 µM 0.564777688052821 0.267398672212663 no 931 0.286112492451077 1440 24207032
SGTC_139 0099-0334 718.624 µM 0.562667201833678 0.268094949291925 no 932 0.286830760968084 1409 97690
SGTC_730 1436-0052 41.2 µM 0.561639644378948 0.268434283990285 no 933 0.287180781936681 1392 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1966 st070145 16.1 µM 0.561568313863272 0.268457847785717 no 934 0.28720508703602 1314 3748532
SGTC_2341 7987486 176.74 µM 0.560051336861474 0.268959222142951 no 935 0.287722210880294 1450 1258686
SGTC_539 4859-0462 2.54 µM 0.559919123674452 0.269002942034157 no 936 0.287767302003851 1428 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2825 7998094 58.44 µM 0.558020859407265 0.269631047834616 no 937 0.288415070155637 1411 2987815
SGTC_287 k060-0039 29.6 µM 0.557935361253467 0.269659355111528 no 938 0.288444261915223 1472 5861974
SGTC_2349 9023730 187.07 µM 0.556150652436593 0.270250587614497 no 939 0.289053935357096 1489 4126287
SGTC_1861 st057647 17.4 µM 0.556062003195705 0.270279971934124 no 940 0.289084234572324 1499 688668
SGTC_136 0097-0015 404.482 µM 0.552744040607826 0.271380915288103 no 941 0.290219345874747 1414 4861337
SGTC_1664 st014217 9.02 µM 0.551356044054282 0.271842132682244 no 942 0.290694813333786 1448 3982782
SGTC_1500 4488-1866 171 µM 0.550901152789998 0.271993373317531 no 943 0.290850718592307 1499 2900003
SGTC_3068 9116768 49.47 µM 0.549362091999048 0.272505384896308 no 944 0.291378491784059 1387 41904888
SGTC_3084 9116877 49.47 µM 0.545573387992265 0.273767838749171 no 945 0.292679610694599 1363 27241325
SGTC_195 4234-0266 16.654 µM 0.544400745687543 0.274159166382705 no 946 0.293082866388363 1400 2303354
SGTC_2208 7283366 200 µM 0.544193243603091 0.274228441579833 no 947 0.293154250351738 1473 898663
SGTC_1766 st045414 44.774 µM 0.543966572002971 0.274304126455857 no 948 0.293232238141018 1433 253960
SGTC_2080 5212524 12.4 µM 0.543451363880817 0.274476191046853 no 949 0.293409534500153 1448 260183
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.540392805146726 0.275498756359136 no 950 0.294463084297595 1451 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_3167 9103034 49.47 µM 0.539105357208357 0.275929747406203 no 951 0.294907079642549 1428 5127859
SGTC_2079 5212404 121 µM 0.538616787189334 0.276093389637965 no 952 0.295075650912617 1492 758462
SGTC_2572 astragaloside iv 100 µM 0.536887696073094 0.276672915909759 no 953 0.295672595221841 1445 45006101 An anti-inflammatory agent.
SGTC_176 1486-1328 72.834 µM 0.53544092924547 0.277158275310649 no 954 0.296172497127895 1418 22310231
SGTC_1699 st031318 29.054 µM 0.535161038784189 0.277252220658689 no 955 0.296269252534216 1481 5340658
SGTC_2107 5363541 170.161 µM 0.535019839642312 0.277299620118584 no 956 0.296318069202846 1406 244052
SGTC_3063 1327-0034 4 µM 0.533930020021893 0.277665597415826 no 957 0.296694975716313 1360 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1977 st070720 65.3 µM 0.533796079116453 0.277710592997678 no 958 0.296741313388617 1420 682188
SGTC_1891 st059073 26.2 µM 0.533581297463811 0.27778275333585 no 959 0.296815625325772 1546 688754
SGTC_1558 st069300 45.6 µM 0.532447955370258 0.278163674598069 no 960 0.297207889404815 1472 24208000
SGTC_110 0850-0284 111.64 µM 0.53094114968995 0.278670512782815 no 961 0.297729780583363 1327 3906265
SGTC_454 lyso-paf C-16 6.67 µM 0.529136129390499 0.279278251549343 no 962 0.298355509981573 1351 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1331 1472-0049 76.2 µM 0.528602742431014 0.279457962721445 no 963 0.298540528733494 1390 24051409
SGTC_2967 9089538 49.85 µM 0.527813419780314 0.279724007922098 no 964 0.298814420970412 1545 728216
SGTC_914 3820-6779 408 µM 0.527778460532099 0.279735793955494 no 965 0.298826554349246 1407 2893481
SGTC_2048 5246248 200 µM 0.527265750791372 0.279908674722104 no 966 0.299004527295321 1456 677046
SGTC_320 4092-0846 5.34 µM 0.526285250319116 0.280239434217738 no 967 0.299345014773853 1482 1359356
SGTC_3216 9129716 49.47 µM 0.525756409109431 0.280417910710169 no 968 0.2995287325432 1385 8056934
SGTC_72 0744-0168 198.391 µM 0.524710491678959 0.280771055136358 no 969 0.299892231362282 1488 677577
SGTC_551 k048-0028 34.9 µM 0.523807548828535 0.281076098380364 no 970 0.300206201206838 1503 6836383
SGTC_3348 9149464 3.537 µM 0.521505074251538 0.281854672491338 no 971 0.301007485833288 1430 1951442
SGTC_2310 7668677 200 µM 0.521126358436104 0.281982833437663 no 972 0.30113937507875 1502 2197143
SGTC_1352 1496-0991 99 µM 0.521110225841725 0.281988293480563 no 973 0.301144993895229 1450 3000039
SGTC_732 3970-1727 52.7 µM 0.519310800717184 0.282597624538365 no 974 0.30177201136138 1568 1275699
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.518335416617318 0.282928178675298 no 975 0.302112133257305 1468 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1571 st070080 73.4 µM 0.517620938700546 0.283170430397679 no 976 0.302361384861425 1554 4315245
SGTC_2147 5545932 89.7195 µM 0.515063142214545 0.284038494770511 no 977 0.303254448761245 1451 797404
SGTC_2619 obliquin 87.91 µM 0.514599792351133 0.284195882428936 no 978 0.303416355122896 1494 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2156 5649887 115 µM 0.513287644757705 0.28464181026544 no 979 0.303875062644559 1552 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_186 3455-3465 67.277 µM 0.513280853603615 0.284644119079264 no 980 0.303877437536654 1440 755278
SGTC_3314 9135860 59.4275 µM 0.510632598643028 0.285545136972892 no 981 0.304804172487335 1473 25252478
SGTC_70 0141-0289 43.283 µM 0.510484249312359 0.285595650111499 no 982 0.304856123247438 1568 352408
SGTC_1448 4255-0083 152 µM 0.508762580359473 0.286182191453374 no 983 0.305459325640332 1607 5399660
SGTC_356 1634-0012 32.5 µM 0.506226537239557 0.287047215933645 no 984 0.306348813823987 1504 735457
SGTC_303 1348-1668 34.2 µM 0.505986580887916 0.287129127250804 no 985 0.306433035016244 1479 5380509
SGTC_2467 5474540 200 µM 0.501206155013287 0.288763271481199 no 986 0.308113021491317 1445 5413519
SGTC_2898 9056270 58.44 µM 0.500932750566462 0.288856864484115 no 987 0.308209226205001 1466 19154699
SGTC_1186 1319-0216 26 µM 0.500627505968404 0.288961374012246 no 988 0.308316650300685 1595 4565136
SGTC_2309 7664088 163.95 µM 0.498944077685547 0.289538064909731 no 989 0.308909390444565 1527 704922
SGTC_718 1130-0073 349 µM 0.498827493754825 0.289578022990473 no 990 0.308950458451643 1551 6740020
SGTC_2360 9040895 200 µM 0.497567530891585 0.290010028890825 no 991 0.309394446907741 1442 4914414
SGTC_1619 st003326 88.7 µM 0.495149378950618 0.290839990635489 no 992 0.310247340071454 1554 2849032
SGTC_1426 4048-4480 71.7 µM 0.493455782745677 0.29142192960947 no 993 0.310845287797064 1559 14224343
SGTC_1711 st032263 62.8 µM 0.492335182855115 0.291807278896747 no 994 0.31124120610076 1529 3958979
SGTC_622 1348-1566 26.3 µM 0.492307920651963 0.291816656717136 no 995 0.311250840813186 1575 7340407
SGTC_1494 4358-1428 177 µM 0.491949776006081 0.291939866552133 no 996 0.311377424418906 1598 1564571
SGTC_366 0181-0206 4.31 µM 0.491919920694692 0.291950138546353 no 997 0.311387977567699 1643 274874
SGTC_1062 mesoridazine 14.2 µM 0.491875717468002 0.291965347381729 no 998 0.31140360265094 1501 4078 A neuroleptic.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.490776643639382 0.29234362008464 no 999 0.311792215596963 1463 803109
SGTC_2641 levomentholum 100 µM 0.488889598403189 0.292993623134 no 1000 0.312459930057873 1476 16666
SGTC_3180 9109287 49.47 µM 0.488634138096775 0.293081669340504 no 1001 0.312550369856776 1493 18891271
SGTC_419 nsc-638432 893 µM 0.487428077192431 0.293497512427064 no 1002 0.31297750015585 1498 368090
SGTC_1409 3909-8004 61.9 µM 0.485580498936652 0.294135076537107 no 1003 0.313632312800923 1519 2119279
SGTC_1955 wogonin 32.4 µM 0.485442096485535 0.294182862346842 no 1004 0.313681388628793 1582 5281703 A flavanone.
SGTC_1938 st074717 56.4 µM 0.48495811280407 0.294349994174216 no 1005 0.313853029284219 1431 17250979
SGTC_663 1486-0733 13.9 µM 0.482057741810736 0.295352483170651 no 1006 0.314882464067878 1501 722445 YPR165W RHO1
SGTC_1769 st044406 64.4 µM 0.482007610778865 0.295369824346133 no 1007 0.314900269862255 1514 670903
SGTC_1780 st038448 24.544 µM 0.481079679171843 0.295690896202433 no 1008 0.315229934974882 1609 728868 YDL195W SEC31
SGTC_1288 0973-0013 65.5 µM 0.479798421530603 0.296134485163697 no 1009 0.315685367685966 1555 4315430
SGTC_1075 aripiprazole 15.2 µM 0.47841331448578 0.296614371384142 no 1010 0.316178029465552 1500 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1655 st012546 55.1 µM 0.477016626676481 0.297098630261509 no 1011 0.316675141026473 1500 720985 YLR208W SEC13
SGTC_3149 9097855 49.47 µM 0.475162391404349 0.297742087704468 no 1012 0.317335615438908 1640 25236625 YMR079W SEC14
SGTC_487 nimodipine 119 µM 0.471076279002167 0.299162291272595 no 1013 0.318793131967111 1558 4497 L-type voltage-gated calcium channels inhibitor
SGTC_3144 9087057 49.47 µM 0.468861574539145 0.299933335145108 no 1014 0.319584291917181 1633 17249618
SGTC_1698 5-fluorocytosine 1.055 µM 0.467901054379181 0.300268017245496 no 1015 0.319927674724081 1584 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3016 9080866 49.47 µM 0.466381572944181 0.300797807366426 no 1016 0.320471199495206 1487 17066299
SGTC_2969 9091408 28.7 µM 0.466263038642181 0.300839153865094 no 1017 0.32051361591756 1453 4286311
SGTC_3076 9116187 49.47 µM 0.465589402163251 0.301074176791248 no 1018 0.320754715112774 1636 27241210
SGTC_429 1112-0049 25.5 µM 0.463783989190489 0.301704469368747 no 1019 0.321401257743032 1484 2836170
SGTC_3327 9140648 26.9345 µM 0.461922468293831 0.302354970450667 no 1020 0.322068460455591 1610 8029710
SGTC_515 4092-1064 102 µM 0.461400947737644 0.302537326490489 no 1021 0.322255485845516 1663 717353
SGTC_2650 prasterone 100 µM 0.461095460877269 0.302644166598472 no 1022 0.322365059095826 1529 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.461079947092625 0.302649592796557 no 1023 0.322370624054129 1559 688662
SGTC_3278 9139605 49.47 µM 0.46079469723058 0.302749371335898 no 1024 0.322472953284268 1601 7958859
SGTC_3305 9127027 53.8275 µM 0.460335748066404 0.302909939672408 no 1025 0.322637622835871 1544 41905295
SGTC_2466 5983409 37.09 µM 0.460034363008328 0.303015403231174 no 1026 0.32274577779776 1524 2879657
SGTC_323 4013-0906 34.3 µM 0.459832353310748 0.303086101603593 no 1027 0.322818279339177 1616 2910086
SGTC_744 1594-0068 283 µM 0.459584610419295 0.303172815529242 no 1028 0.322907203777455 1543 668392
SGTC_554 4483-2211 187 µM 0.459365453324471 0.303249533221324 no 1029 0.322985876115958 1548 747107
SGTC_123 0083-0120 66.675 µM 0.458186278955082 0.303662461519209 no 1030 0.323409308380388 1465 16001701
SGTC_1368 1852-0141 284 µM 0.457756286962354 0.303813100369261 no 1031 0.323563772093111 1528 2838987
SGTC_863 0466-0191 129 µM 0.456258192969893 0.304338186988353 no 1032 0.3241021617092 1597 765160 YPR165W RHO1
SGTC_1322 1348-1070 12 µM 0.456255213308203 0.304339231771618 no 1033 0.324103232916301 1522 6758089
SGTC_1775 st081588 35.1725 µM 0.453680464365557 0.305242633314369 no 1034 0.325029414852667 1539 1426443 YGL099W LSG1
SGTC_2405 ticlatone 3.52 µM 0.452883726515309 0.30552242542322 no 1035 0.325316234846787 1378 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1145 3546-0597 10.2 µM 0.448689124361488 0.306997323342245 no 1036 0.326827965585771 1548 875334
SGTC_2462 5162487 171.77 µM 0.448272065420334 0.307144140193472 no 1037 0.326978429246264 1571 2259986
SGTC_768 0384-0033 77.3 µM 0.448252143334331 0.307151154119923 no 1038 0.326985617303815 1517 3965305 YMR134W ERG29
SGTC_2411 st077133 39.94 µM 0.447322254013518 0.307478616747875 no 1039 0.327321200639989 1705 1403142 YNL221C POP1
SGTC_1192 1488-0095 21.4 µM 0.446891510986838 0.307630355915901 no 1040 0.327476696773264 1565 915875
SGTC_2725 haloperidol 53.21 µM 0.446037055878062 0.307931454833682 no 1041 0.327785239468608 1531 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.4459680572616 0.307955774700049 no 1042 0.327810159919305 1526 91467 include heat shock
SGTC_1855 st056195 39.6 µM 0.444628733730227 0.308428011575912 no 1043 0.328294039470463 1652 4028379
SGTC_2290 7904846 200 µM 0.444372708004764 0.30851832073263 no 1044 0.328386570953957 1541 2962154
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.44095097723908 0.309726394264926 no 1045 0.329624243721669 1606 2724278 An inhibitor of dopamine biosynthesis.
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.439760240412274 0.310147278274362 no 1046 0.330055383549815 1696 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_3344 9148862 3.898 µM 0.43901729471996 0.310410009814829 no 1047 0.330324502413196 1649 4905352
SGTC_2470 5664817 21.68 µM 0.438242491506818 0.310684110369838 no 1048 0.330605254614283 1590 2859561
SGTC_1644 st010134 20.9 µM 0.436316221344871 0.311366018328028 no 1049 0.33130365710965 1606 3818134
SGTC_2785 7756463 72.73 µM 0.435982665767034 0.311484164299764 no 1050 0.331424653147031 1510 2201551
SGTC_3302 9125395 16.351 µM 0.435554339500512 0.311635906687837 no 1051 0.33158005270241 1606 17599668
SGTC_1306 1185-0270 9.02 µM 0.435334543845063 0.311713785728065 no 1052 0.331659807253749 1660 1548076
SGTC_3202 9113761 49.47 µM 0.435032941690773 0.31182066454183 no 1053 0.331769258345381 1733 4798415
SGTC_1486 3970-0793 4.53 µM 0.43455509571123 0.31199003136088 no 1054 0.331942697527357 1634 2844330
SGTC_39 0986-0283 58.349 µM 0.4338333416496 0.312245923863839 no 1055 0.332204733969284 1720 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1035 k081-0041 55.2 µM 0.432710612046632 0.312644159292646 no 1056 0.332612509668311 1638 731709
SGTC_1144 3486-0183 12.5 µM 0.432626826813934 0.312673886936524 no 1057 0.332642948438388 1584 6744069
SGTC_1531 st059297 52.4 µM 0.43214778147123 0.3128438793001 no 1058 0.332817004479504 1591 7566702
SGTC_2859 9028643 45.46 µM 0.430463773218293 0.313441776344751 no 1059 0.333429156792758 1629 17151580
SGTC_2944 9067346 25.62 µM 0.429777326000349 0.313685636150805 no 1060 0.333678814034403 1620 6473075
SGTC_1079 idarubicin 2.36 µM 0.429227490108519 0.313881023638377 no 1061 0.333878839593221 1598 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.428086956354547 0.314286485556761 no 1062 0.334293906426824 1626 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1736 st036774 51 µM 0.427512779103957 0.314490691534751 no 1063 0.334502939657912 1773 1272247
SGTC_2640 pentamidine 10.38 µM 0.426822654417031 0.314736209306873 no 1064 0.334754252264406 1707 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3226 9131256 49.47 µM 0.423871438024177 0.315787052982112 no 1065 0.33582978761332 1529 17178073
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.422806724444182 0.31616653339411 no 1066 0.33621814054433 1670 5282309
SGTC_69 0096-0274 206.684 µM 0.42037866636875 0.317032655079025 no 1067 0.337104425159706 1674 6741392
SGTC_292 k038-0015 474 µM 0.41952759036927 0.317336483336214 no 1068 0.337415297565612 1620 46368540
SGTC_1162 k048-0130 20.1 µM 0.418917899030704 0.317554214648626 no 1069 0.337638067694121 1586 6797406
SGTC_843 0310-0051 143 µM 0.417428330140417 0.318086430843205 no 1070 0.338182568289235 1621 2065037
SGTC_891 0929-0073 133 µM 0.416969159213912 0.318250566368985 no 1071 0.338350483069924 1658 5603632
SGTC_201 4262-0159 12.803 µM 0.413920651628755 0.31934119162663 no 1072 0.33946610949817 1691 1341029
SGTC_3001 9076041 71.4286 µM 0.413549430316505 0.319474105762101 no 1073 0.339602057372286 1592 16004211
SGTC_2492 derrusnin 100 µM 0.413117634172659 0.319628737628915 no 1074 0.339760215089212 1550 1715307 Part of coumarin class of compounds.
SGTC_2659 sanguinarine 24.21 µM 0.410213444028724 0.320669579968009 no 1075 0.340824689842668 1606 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_3004 9076122 71.4286 µM 0.409659756802735 0.320868178227213 no 1076 0.341027777440276 1686 44782551
SGTC_111 0083-0039 52.457 µM 0.408462266820153 0.321297872953453 no 1077 0.341467163715996 1596 759313
SGTC_1332 1480-0653 17.5 µM 0.408312029022565 0.321351799613603 no 1078 0.341522304564342 1714 5749438
SGTC_2047 4141938 200 µM 0.405143695929757 0.322489923234938 no 1079 0.342685944481608 1634 3807862
SGTC_644 1498-1197 63.3 µM 0.403708639650303 0.323005970609403 no 1080 0.343213492810013 1686 6741615
SGTC_2185 6113692 200 µM 0.403039208680996 0.32324681518277 no 1081 0.34345969035493 1628 874150
SGTC_1880 MG-132 525 µM 0.399990333450785 0.324344660516128 no 1082 0.344581818297994 1706 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_3340 9146634 11.102 µM 0.399514107454836 0.324516279236861 no 1083 0.344757215488635 1613 4907387
SGTC_1272 0839-0021 27 µM 0.399465529609154 0.3245337874488 no 1084 0.344775108907534 1641 5027250
SGTC_390 dec-rvkr-cmk 16.7 µM 0.399354018469923 0.324573979266415 no 1085 0.344816184819736 1660 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1492 4158-0558 28.5 µM 0.398348381231917 0.324936532059568 no 1086 0.345186700949449 1736 3967268
SGTC_1038 k292-0204 154 µM 0.397710719699621 0.3251665080374 no 1087 0.345421717354385 1570 4454212
SGTC_2106 5357045 167.29 µM 0.397144093423151 0.32537092067853 no 1088 0.345630603040471 1706 668842
SGTC_2763 lisinopril 49.32 µM 0.395715968520672 0.325886355323712 no 1089 0.346157286970967 1655 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2775 cyproheptadine 69.59 µM 0.395421138270196 0.325992806085668 no 1090 0.346266055712617 1666 2913 A selective serotonin reuptake inhibitor.
SGTC_261 5-fluorouridine 15.376 µM 0.394929837782606 0.326170225466918 no 1091 0.34644733440006 1701 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_519 k048-0011 62.8 µM 0.394063952941596 0.32648301124748 no 1092 0.346766911788512 1679 6836379
SGTC_2840 9008771 71.43 µM 0.393035032618173 0.326854849414376 no 1093 0.347146803457187 1782 2992978
SGTC_2364 9055074 200 µM 0.392319725253391 0.327113453396082 no 1094 0.347410995432458 1577 6470630
SGTC_1031 k035-0009 16 µM 0.391118992746264 0.327547739006749 no 1095 0.347854641216339 1762 5180959
SGTC_92 0063-0024 660.874 µM 0.390274572081866 0.327853292214102 no 1096 0.348166762000522 1653 3594437
SGTC_1008 4106-0037 6 µM 0.390272273491751 0.327854124115237 no 1097 0.348167611762271 1645 2905394
SGTC_1688 st021091 57.6 µM 0.390008944126266 0.327949433405916 no 1098 0.348264966578694 1759 3656366
SGTC_2909 7941780 10.49 µM 0.38933052387384 0.328195032083678 no 1099 0.348515829619736 1783 1243215
SGTC_2549 cedrol 20.94 µM 0.388350905279246 0.328549800302177 no 1100 0.348878185270036 1707 6708665 A sedative which affects the nervous system.
SGTC_3225 9130819 49.47 µM 0.387495790940728 0.328859605789222 no 1101 0.349194600183038 1686 4547121
SGTC_3015 9080845 49.47 µM 0.386799212954157 0.329112060957168 no 1102 0.349452429966112 1758 5296973
SGTC_2557 derrustone 83.84 µM 0.386353695608413 0.329273567114367 no 1103 0.349617369173158 1589 629853 An antioxidant.
SGTC_1403 3909-7815 62.9 µM 0.386282024733714 0.329299551766893 no 1104 0.349643905780173 1686 6615483
SGTC_3056 9094900 49.47 µM 0.386168934997283 0.329340554722467 no 1105 0.349685779484029 1556 25236784
SGTC_3145 9085516 49.47 µM 0.386082206685109 0.329372001204754 no 1106 0.349717893590004 1599 25236195
SGTC_2737 bleomycin 30.5 nM 0.385937507947984 0.329424469645096 no 1107 0.349771475610171 1652 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_376 3970-0862 59.1 µM 0.384157268078313 0.330070267552183 no 1108 0.350430943974124 1740 3135186
SGTC_1673 st016611 27.3 µM 0.383808453229509 0.330196862676748 no 1109 0.350560211138719 1745 5226799
SGTC_1742 st038235 28.8875 µM 0.381227908522421 0.33113402105551 no 1110 0.35151707098823 1659 564103 YBR002C RER2
SGTC_3233 9132340 49.47 µM 0.380190808495923 0.331510956034365 no 1111 0.351901890830184 1593 17682950
SGTC_2796 7949634 45.45 µM 0.378326157187028 0.332189094490002 no 1112 0.352594158158225 1625 2971588
SGTC_1405 3909-7894 12 µM 0.377553029451687 0.332470427834524 no 1113 0.352881331657018 1740 7104060
SGTC_2189 6047310 154.431 µM 0.375573661408472 0.333191129721906 no 1114 0.353616937365338 1651 711535
SGTC_1266 0828-0227 32.9 µM 0.374980605765222 0.333407185604458 no 1115 0.353837445198495 1711 3913820
SGTC_1045 1348-1485 165 µM 0.374848968775139 0.333455149726972 no 1116 0.353886396647798 1642 6810614
SGTC_1078 idebenone 36.1 µM 0.373799242474655 0.333837732307246 no 1117 0.354276841565011 1667 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_318 1488-0629 67.2 µM 0.373150732670623 0.334074174157361 no 1118 0.354518130904026 1633 3662576
SGTC_2155 5570423 76 µM 0.372603422513564 0.334273770628523 no 1119 0.354721812598693 1665 797402
SGTC_1131 3454-3128 32.3 µM 0.371944211408202 0.334514238052091 no 1120 0.354967193420623 1762 710982
SGTC_2506 ethyl hematommate 54.16 µM 0.37150239042584 0.334675443790543 no 1121 0.355131687920841 1588 3940691 An allergen.
SGTC_118 0083-0097 135.343 µM 0.370788267816307 0.334936067742893 no 1122 0.355397620200984 1677 5207356
SGTC_1234 0326-0494 15.5 µM 0.365741007577375 0.336780360798394 no 1123 0.357279171690213 1771 1547813
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.365727578123772 0.336785273249069 no 1124 0.35728418266771 1660 442882
SGTC_2210 7115885 190.385 µM 0.362040553206985 0.338135025800813 no 1125 0.358660863001559 1702 2927039
SGTC_1284 0929-0043 16 µM 0.361581894537392 0.338303078412628 no 1126 0.358832248273164 1667 1239883
SGTC_1310 1188-0297 994 nM 0.360486336046849 0.338704621550563 no 1127 0.359241736501461 1699 1588352
SGTC_2105 5350118 200 µM 0.360250783876515 0.338790979895954 no 1128 0.359329800264693 1647 2133313
SGTC_2851 9015922 71.43 µM 0.358774309070907 0.339332479282746 no 1129 0.359881966631281 1768 2996893
SGTC_919 tnp00227 403.569 nM 0.358092129053371 0.339582782034043 no 1130 0.360137184570049 1704 1269246 A methoxyflavone. YNL221C POP1
SGTC_1795 st049545 62.3 µM 0.357907867888942 0.339650402544239 no 1131 0.360206131259495 1821 5291882
SGTC_2906 7926292 26.41 µM 0.357120434645947 0.339939434420222 no 1132 0.360500823587566 1660 2966319
SGTC_974 1326-0144 138 µM 0.356077829004925 0.340322273562434 no 1133 0.360891140201241 1664 5411856
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.355443781165314 0.340555173025464 no 1134 0.361128577358 1804 94937 An inhibitor of serotonin biosynthesis.
SGTC_3171 9103192 49.47 µM 0.353942268023755 0.341106953614062 no 1135 0.36169107472518 1770 13018434
SGTC_2252 omeprazole 400 µM 0.35275434843056 0.341543734854867 no 1136 0.362136305488498 1770 4594 A proton pump inhibitor.
SGTC_574 1315-0397 40 µM 0.352485117169748 0.341642756912369 no 1137 0.36223723898425 1688 6794277
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.352300879555631 0.341710524966952 no 1138 0.362306314294236 1734 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1059 3448-6867 171 µM 0.349280274880809 0.342822318994856 no 1139 0.363439452723143 1838 3934407
SGTC_1648 st011736 69.8 µM 0.347872841928014 0.343340818849026 no 1140 0.363967840959143 1782 2855514
SGTC_1138 3761-0006 1.03 µM 0.346931258495386 0.343687863988446 no 1141 0.364321481262002 1736 12061087
SGTC_775 4577-0580 57.3 µM 0.346522423174171 0.343838591961136 no 1142 0.364475067795901 1746 2006902
SGTC_1561 5-methoxyflavone 52.9 µM 0.345757073299111 0.344120825187098 no 1143 0.364762644081124 1779 94525
SGTC_1746 st038117 42 µM 0.345522882176348 0.344207203725705 no 1144 0.364850655407377 1699 2898218
SGTC_592 k241-0073 46.5 µM 0.345031526555846 0.344388460665548 no 1145 0.365035334821944 1805 4230158
SGTC_1799 st045822 46.1415 µM 0.344550511968823 0.344565937510345 no 1146 0.365216157818085 1826 3674992
SGTC_1563 conessine 56.1 µM 0.343971995765942 0.344779434223346 no 1147 0.365433673316207 1804 441082 An anti-amoebic, histamine inhibitor.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.343798702340053 0.344843396382675 no 1148 0.365498838097593 1701 689007
SGTC_2223 6903751 107.57 µM 0.339181664084897 0.346549161300828 no 1149 0.367236440683142 1793 5598863
SGTC_1609 st001574 46.4 µM 0.337989322610526 0.346990179578804 no 1150 0.367685617056616 1690 3960012
SGTC_426 0988-0037 14.6 µM 0.337931364736775 0.34701162208374 no 1151 0.367707455443811 1894 5383008
SGTC_2104 5389443 200 µM 0.336526850180684 0.347531395858333 no 1152 0.36823680376582 1800 2244536
SGTC_16 erodoxin 22.806 µM 0.332897465741595 0.348875861319607 no 1153 0.369605841244997 1738 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3230 9131665 49.47 µM 0.331894407677871 0.34924776890536 no 1154 0.369984496652503 1746 15943720
SGTC_1824 st053723 68.6 µM 0.331692399200383 0.349322685872773 no 1155 0.370060770315238 1677 675225
SGTC_207 4185-0010 4.486 µM 0.330958090976321 0.349595061236148 no 1156 0.370338070911272 1812 3761753
SGTC_886 0866-0150 153 µM 0.329922983231662 0.349979143025704 no 1157 0.370729078416261 1866 271463
SGTC_931 2812-0076 566 µM 0.329063281518444 0.35029825628834 no 1158 0.371053928586438 1702 3450959
SGTC_1888 azatryptophan 97.5 µM 0.328311107421184 0.350577543018718 no 1159 0.371338223355558 1711 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_646 4092-0839 27.3 µM 0.327457933979146 0.350894429191781 no 1160 0.371660777228094 1823 877796
SGTC_2946 9065502 71.43 µM 0.326154837406382 0.351378626244149 no 1161 0.372153604566734 1723 16489101
SGTC_502 l-744,832 89.3 µM 0.324156748773286 0.352121532850711 no 1162 0.372909682526524 1855 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1512 0259-0544 12.2 µM 0.324104567241866 0.352140941973593 no 1163 0.372929434625304 1795 18476
SGTC_2312 7706453 155.7 µM 0.323731461267014 0.352279731407476 no 1164 0.373070674899979 1721 976098
SGTC_653 0203-0016 55.2 µM 0.323556662081777 0.352344760667853 no 1165 0.37313685147366 1785 295302
SGTC_3151 9099821 49.47 µM 0.322973503601806 0.352561740059422 no 1166 0.373357654336904 1694 17174189
SGTC_3065 9113888 49.47 µM 0.321918181569445 0.352954522213317 no 1167 0.373757339445189 1816 16648368
SGTC_2954 9074818 52.69 µM 0.321163637971989 0.353235453247456 no 1168 0.374043193169629 1802 16648742
SGTC_1881 5652484 16 µM 0.320000473942921 0.353668678163167 no 1169 0.374483985637859 1856 2255129
SGTC_1088 bifonazole 369 nM 0.319770467168484 0.353754367540193 no 1170 0.374571168420988 1748 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1726 st035556 14.5795 µM 0.318046450502409 0.354396888254343 no 1171 0.375224851190104 1854 5919439
SGTC_99 0109-0120 622.8 µM 0.317747719262124 0.354508264067619 no 1172 0.375338155419035 1835 759414
SGTC_2536 dehydroabietamide 32.04 µM 0.317588495834273 0.354567632339061 no 1173 0.375398550845122 1862 3983547
SGTC_1976 st070609 63.5 µM 0.317377660830336 0.354646250011924 no 1174 0.37547852788311 1748 682556
SGTC_1134 3477-0009 42.5 µM 0.315697274374941 0.355273065692043 no 1175 0.376116147858266 1912 3973534
SGTC_2123 5259487 200 µM 0.314953075219602 0.355550791215703 no 1176 0.376398641245983 1852 2173474
SGTC_2204 7233102 200 µM 0.314006644246037 0.355904097843525 no 1177 0.376757996218726 1810 2172480
SGTC_691 1548-0686 185 µM 0.312681547173986 0.356398970046125 no 1178 0.377261308158924 1707 46495133
SGTC_1851 st056236 18.9 µM 0.311951021732962 0.356671896375315 no 1179 0.377538873057173 1886 5393171
SGTC_3042 9091578 49.47 µM 0.31137389441809 0.356887564646018 no 1180 0.37775819870511 1802 25236497
SGTC_2771 fluoxetine 41.05 µM 0.310723738209507 0.357130578078276 no 1181 0.378005324728517 1846 3386 A selective serotonin reuptake inhibitor.
SGTC_711 k292-0785 179 µM 0.30960719652778 0.357548050884248 no 1182 0.378429841500248 1730 4146315
SGTC_1623 st003709 20.3 µM 0.30739948396914 0.358374011881427 no 1183 0.379269660460178 1718 16192618
SGTC_3291 9121177 71.43 µM 0.305427968010082 0.359112166405157 no 1184 0.38002011170283 1743 17015612
SGTC_3135 9127742 49.47 µM 0.305423675498478 0.359113774137914 no 1185 0.380021746127759 1734 3643468
SGTC_3319 9138450 16.7555 µM 0.303836849687646 0.359708280325168 no 1186 0.380626095539931 1781 2029690
SGTC_1657 st012939 43.4 µM 0.302432018226732 0.360234885621946 no 1187 0.381161374893874 1874 24207257
SGTC_2376 9072922 81.32 µM 0.301638809213464 0.360532339657961 no 1188 0.381463709843397 1804 17087968
SGTC_1724 st037281 8.293 µM 0.299491057848469 0.361338171481498 no 1189 0.382282696956971 1732 574124 YDL195W SEC31
SGTC_3161 9100388 49.47 µM 0.299451661010063 0.361352958853159 no 1190 0.382297724812117 1823 25236368
SGTC_986 1493-0483 84 µM 0.298637915847186 0.361658439611081 no 1191 0.382608166101132 1893 40079
SGTC_2346 9031566 143.75 µM 0.298334928895758 0.361772203761138 no 1192 0.382723773982418 1878 4771086
SGTC_514 4466-0038 2.65 nM 0.298248795517415 0.361804546957447 no 1193 0.38275664099359 1807 5722064
SGTC_2347 9049783 174.81 µM 0.297451986693779 0.362103796491996 no 1194 0.383060729498922 1855 6467988 YPL169C MEX67
SGTC_137 0438-0332 85.389 µM 0.297251800784956 0.362178991573645 no 1195 0.383137138375105 1818 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2755 lomerizine 42.69 µM 0.295891176629695 0.362690218520498 no 1196 0.383656594776904 1731 3949 A calcium channel blocker.
SGTC_916 4466-0038 42 nM 0.295149196047265 0.362969105922255 no 1197 0.383939954849204 1951 5722064 YGL116W CDC20
SGTC_148 3253-0744 288.01 µM 0.294941851451639 0.363047053301215 no 1198 0.384019150204904 1736 6893655
SGTC_167 3672-0051 66.205 µM 0.294600785290572 0.363175283178305 no 1199 0.384149431103329 1741 3237971
SGTC_530 4358-1714 28 µM 0.294041336300474 0.363385651163365 no 1200 0.384363158501901 1836 1564641
SGTC_675 1309-0189 238 µM 0.293889463754121 0.363442766472014 no 1201 0.384421184740389 1775 4246530
SGTC_1770 st043884 66.3 µM 0.293882683584208 0.363445316388105 no 1202 0.384423775313468 1777 670149
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.293512974436952 0.36358436738561 no 1203 0.384565041910216 1872 140250 A respiratory chain inhibitor.
SGTC_2172 5754775 163.918 µM 0.292830045146894 0.363841270599494 no 1204 0.384826030844149 1739 2263357
SGTC_2979 9012552 45.46 µM 0.292142646359395 0.364099916964967 no 1205 0.385088780557312 1874 17100905
SGTC_3071 9117417 49.47 µM 0.291078743815657 0.364500351791072 no 1206 0.385495548190419 1936 45595590 YGL055W OLE1
SGTC_829 1635-0120 117 µM 0.288547625291394 0.365453615595797 no 1207 0.386463790106906 1906 285054
SGTC_1132 3456-3614 2.5 µM 0.288277066475898 0.36555556211583 no 1208 0.386567330326314 1965 3125502
SGTC_2918 7977171 22.06 µM 0.287274575685761 0.365933383234448 no 1209 0.386951044117423 1798 2236483
SGTC_2175 5807670 165.306 µM 0.285685479986745 0.36653255176018 no 1210 0.387559513355648 1912 241186
SGTC_245 methotrexate 289.6 µM 0.285545385213972 0.36658539012434 no 1211 0.387613169313879 1853 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3116 9124943 49.47 µM 0.285440210376108 0.366625059692909 no 1212 0.387653452432382 1701 41905195 YPL160W CDC60
SGTC_3017 9080681 49.47 µM 0.284452472397466 0.366997681573132 no 1213 0.38803182588564 1769 16451914
SGTC_2571 chrysanthemic acid 100 µM 0.284397083253006 0.367018580714884 no 1214 0.388053046994044 1724 2743 An insecticide.
SGTC_1849 st056239 19.2 µM 0.283355844971021 0.367411528561715 no 1215 0.388452036230987 1699 5393181
SGTC_79 0052-0007 94.094 µM 0.282844392184328 0.36760459412835 no 1216 0.388648061562972 1911 2801472
SGTC_1347 1493-0251 600 nM 0.281436066110708 0.368136388385226 no 1217 0.38918797937745 1910 3986378
SGTC_882 0843-0131 351 µM 0.280946138308556 0.368321448034338 no 1218 0.389375855961099 1945 5425421
SGTC_3350 9150499 3.57 µM 0.280733603196242 0.368401738088856 no 1219 0.389457366567991 1810 4910996 YPR165W RHO1
SGTC_2852 9023854 51.95 µM 0.280471940740629 0.36850059502616 no 1220 0.389557724974351 1861 19798528
SGTC_1518 st038567 90.8 µM 0.280202663313905 0.368602338012819 no 1221 0.38966101172808 1806 77966
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.277326606383028 0.36968959216709 no 1222 0.390764665761177 1841 165521
SGTC_2000 st075254 36.4 µM 0.276952133896508 0.369831233293192 no 1223 0.390908430280589 1794 17234175
SGTC_668 1682-0499 62.6 µM 0.276637957757264 0.36995008144941 no 1224 0.391029057806054 1820 682214
SGTC_1383 3049-0032 20.7 µM 0.275127207348629 0.370521749125792 no 1225 0.391609254715509 1934 712864
SGTC_3082 9117008 49.47 µM 0.27486548523392 0.370620813828715 no 1226 0.391709792465516 1812 41448529
SGTC_1636 st007707 68.9 µM 0.274724498457956 0.370674182432001 no 1227 0.391763954024921 1919 403051
SGTC_2418 pentamidine 31.67 µM 0.27469928520136 0.370683726825549 no 1228 0.391773640184961 1919 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2669 eugenol 100 µM 0.270893163334396 0.372125431117234 no 1229 0.393236601685364 1932 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1434 4073-0095 163 µM 0.270867404015278 0.372135194513042 no 1230 0.393246507974997 1909 24133745
SGTC_1990 st072050 59.8 µM 0.268412573199644 0.373066010250582 no 1231 0.394190881240046 1790 17233948
SGTC_133 0724-0033 378.92 µM 0.268282881535019 0.373115207032449 no 1232 0.394240790973225 1894 280309
SGTC_1118 chelidonine 707.474 nM 0.267605338429999 0.373372257482224 no 1233 0.394501560662288 1979 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_546 peri-Naphthalide 147 µM 0.267466735379336 0.373424848503463 no 1234 0.394554911399583 1900 223824 A penicillin ester.
SGTC_1174 0739-0097 51.1 µM 0.265635835678401 0.374119779140805 no 1235 0.395259841964168 1836 728447
SGTC_1030 k029-0042 36.7 µM 0.265146223874814 0.374305684135083 no 1236 0.395448409853509 1847 6080581
SGTC_1718 roemerine 11.9335 µM 0.264547946666628 0.374532888925709 no 1237 0.395678862100374 1875 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1096 rimcazole 32.2 µM 0.263370113974443 0.374980315907642 no 1238 0.396132661638835 1824 18528119 A dopamine reuptake inhibitor.
SGTC_1179 1021-1431 9.29 µM 0.26094782432885 0.375901007032782 no 1239 0.397066371811987 1868 2840958
SGTC_197 4544-0043 41.561 µM 0.260701084594504 0.37599483040784 no 1240 0.397161514794615 1852 896523
SGTC_2154 5570129 200 µM 0.260450453208065 0.376090141097889 no 1241 0.397258164666343 1928 673366
SGTC_3260 9137109 49.47 µM 0.260250110888108 0.376166333179926 no 1242 0.397335426325638 1953 17478346
SGTC_542 3381-0244 89.3 µM 0.25915785627716 0.376581812773719 no 1243 0.397756723149573 1960 1112843
SGTC_3282 9108498 15.4605 µM 0.257918664959707 0.377053358347345 no 1244 0.398234839767594 1819 16459645
SGTC_1208 2323-2347 50.3 µM 0.257611573829826 0.377170243155392 no 1245 0.398353348254596 1990 5412760
SGTC_1495 4469-0029 237 µM 0.256808771987213 0.377475858168461 no 1246 0.398663199031682 1827 793680
SGTC_2769 toremifene 3.73 µM 0.256755048407737 0.377496312697178 no 1247 0.398683936559428 1872 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3128 9127691 49.47 µM 0.256617154726097 0.377548815430432 no 1248 0.398737165410036 1859 41316314
SGTC_257 daunorubicin 18.5 µM 0.256378014510373 0.377639872935935 no 1249 0.398829481275386 1974 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1087 pterostilbene 9.05 µM 0.254534728976165 0.378341969314234 no 1250 0.399541238751701 1959 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2109 5483026 200 µM 0.254463133231019 0.37836924782538 no 1251 0.399568891144429 1852 759335
SGTC_715 0868-0130 184 µM 0.2541010208985 0.378507224599815 no 1252 0.39970875734408 2001 2876258
SGTC_2396 5342950 42.78 µM 0.254089578213772 0.378511584893696 no 1253 0.399713177300753 1844 1886677
SGTC_562 3772-2733 112 µM 0.251261077536334 0.379589872780893 no 1254 0.400806132827685 1969 2876874 YIL048W NEO1
SGTC_2634 4'-methoxyflavone 100 µM 0.250967136847358 0.379701983458764 no 1255 0.400919758597192 1810 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2486 5283202 22.39 µM 0.250882244255259 0.379734363866646 no 1256 0.400952576254446 1782 1377751
SGTC_2594 a-mangostin 100 µM 0.248707235965645 0.380564259830895 no 1257 0.401793625597993 1971 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2561 acetosyringone 100 µM 0.243048067709151 0.382726139854657 no 1258 0.403984080485558 2003 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_234 nsc-17383 10.7 µM 0.241680314244265 0.383249192096053 no 1259 0.404513942201458 1958 408974
SGTC_2385 9074692 200 µM 0.240469662630902 0.383712343573831 no 1260 0.404983089529465 1846 17046906
SGTC_2328 6201408 200 µM 0.2403585927015 0.383754843239982 no 1261 0.405026137797022 1846 2890418
SGTC_2025 5147754 141 µM 0.239790686697888 0.383972167963095 no 1262 0.405246263653185 1988 315777 YLR208W SEC13
SGTC_1419 3993-2473 62.6 µM 0.239586433277298 0.384050340032004 no 1263 0.405325441586714 1902 704026
SGTC_3072 9116419 49.47 µM 0.238839278116416 0.384336332153961 no 1264 0.405615105961747 1844 17170162
SGTC_1987 st072290 61.9 µM 0.238754557133474 0.384368765184316 no 1265 0.405647954681973 1884 54697379
SGTC_2423 st077119 87.2 µM 0.238348605004576 0.38452418369581 no 1266 0.405805363014863 1940 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_272 doxorubicin 8.13 µM 0.238263433585119 0.384556793875673 no 1267 0.405838390249472 1990 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_800 3448-7362 155 µM 0.237599847893244 0.384810893552386 no 1268 0.40609573425001 1976 15991913
SGTC_2746 daunorubicin 9.88 µM 0.236364698592831 0.385283987586053 no 1269 0.406574843303539 1994 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3070 9117005 49.47 µM 0.236220141978002 0.385339367673576 no 1270 0.40663092534479 1961 8779016
SGTC_566 0958-0068 16.5 µM 0.23612340727679 0.385376428343604 no 1271 0.406668455513379 1945 6815365
SGTC_1837 st055472 66.5 µM 0.233132889430283 0.386522660186042 no 1272 0.407829108186223 1929 676091
SGTC_3021 9087658 49.47 µM 0.232015776877445 0.386951091591411 no 1273 0.408262879975607 2018 25237042
SGTC_150 3970-0969 77.2 µM 0.231129663275113 0.387291029043321 no 1274 0.408607035491126 1918 6615640
SGTC_791 1348-1292 225 µM 0.2308415004028 0.387401594854707 no 1275 0.408718969572981 1974 5437054
SGTC_924 2046-0044 21.3 µM 0.230435692694035 0.387557315544518 no 1276 0.40887661427869 1960 3623589
SGTC_6 0844-0013 19.835 µM 0.229019633027793 0.388100842011176 no 1277 0.40942682833657 2005 1584900
SGTC_2076 5212012 200 µM 0.227453827400407 0.388702100741865 no 1278 0.410035434348589 1946 604802
SGTC_1912 st060209 90.8 µM 0.227224577756016 0.388790153467231 no 1279 0.410124558599 1843 688787
SGTC_1640 st009078 66.4 µM 0.225598108621609 0.389415029441562 no 1280 0.410757006016714 1989 690618
SGTC_1906 st060206 94.7 µM 0.224830163167727 0.389710167240598 no 1281 0.411055699959671 2011 5133468
SGTC_290 2043-6722 48.1 µM 0.224749243370675 0.389741270150017 no 1282 0.411087176885545 1959 773758 YLR208W SEC13
SGTC_963 1269-2853 151 µM 0.223639504185789 0.390167888567847 no 1283 0.411518911101288 1850 3668223
SGTC_2099 5377090 177.372 µM 0.223251670787944 0.390317015070539 no 1284 0.411669819550445 1885 2243829
SGTC_192 3455-0609 60.9 µM 0.222885188545812 0.3904579466347 no 1285 0.411812432136722 1939 3769639
SGTC_797 k781-0471 270 µM 0.222793747052004 0.390493112909744 no 1286 0.411848017418106 1961 23738129
SGTC_2808 7946468 45.46 µM 0.221971450987816 0.390809389098341 no 1287 0.412168053880877 1932 2970879
SGTC_3349 9149703 23.001 µM 0.22168443317028 0.390919800543347 no 1288 0.412279774573582 1976 4910494
SGTC_579 4491-1009 110 µM 0.220108499897487 0.39152619488156 no 1289 0.412893327588206 2094 1271041
SGTC_667 1498-1044 59 µM 0.219607478638713 0.391719035295235 no 1290 0.413088433241185 1912 6739982
SGTC_32 0928-0142 34.1 µM 0.219387502788756 0.391803711236927 no 1291 0.413174102123378 2009 2244242
SGTC_2319 6033012 152.6 µM 0.216305073700846 0.392990776991676 no 1292 0.414374977219872 1878 847246
SGTC_2284 7945075 39.21 µM 0.216051667502913 0.393088409999528 no 1293 0.414473736823102 2043 1245402
SGTC_1967 st070177 51.4 µM 0.215090937086454 0.393458623779374 no 1294 0.414848209852442 1992 5729214
SGTC_2444 5485484 36.41 µM 0.214707202938247 0.393606521206212 no 1295 0.414997803207462 1984 6790631
SGTC_3108 9121785 49.47 µM 0.213144270914005 0.394209059185556 no 1296 0.415607217364944 2050 17140271
SGTC_2127 5253358 187.912 µM 0.212268283908986 0.394546878542332 no 1297 0.415948868694372 1887 20612
SGTC_212 3807-4682 38.772 µM 0.211939868538 0.394673550500949 no 1298 0.416076973224861 2009 3125501 YBL034C STU1
SGTC_851 0394-0702 453 µM 0.211463222718861 0.394857415721339 no 1299 0.416262913660346 2059 762646
SGTC_2629 bisabolol 100 µM 0.210682465294047 0.395158641998516 no 1300 0.416567529084248 1974 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2330 7979373 200 µM 0.209865654671388 0.395473845135135 no 1301 0.416886264430239 1816 1863007
SGTC_2055 5235184 200 µM 0.207665675796276 0.396323145602055 no 1302 0.417745010064342 1947 2836034
SGTC_2371 9071574 200 µM 0.206946076546573 0.396601053476397 no 1303 0.418025985723232 2043 45596039
SGTC_1942 st076330 65.2 µM 0.205215897950865 0.397269459943387 no 1304 0.418701724500625 1995 24208414
SGTC_42 0133-0086 60.653 µM 0.202692308211232 0.398244919457143 no 1305 0.41968776777368 1942 162923 Model of phenazepam hydroxylation.
SGTC_55 0767-0285 6.563 µM 0.202661841660276 0.39825669978985 no 1306 0.419699675076095 2052 3116166
SGTC_2630 antimycin a 100 µM 0.201749187551188 0.398609633655578 no 1307 0.420056403529029 1947 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_34 0469-0683 81.75 µM 0.201740892054993 0.398612842000372 no 1308 0.420059646285325 1999 3690923
SGTC_2447 5741742 33.78 µM 0.200865776761426 0.398951337790817 no 1309 0.420401764235689 1986 1776504
SGTC_1381 2324-0066 62.1 µM 0.200424302970805 0.399122129316188 no 1310 0.42057437702897 1953 10885928
SGTC_1915 st067105 30.6 µM 0.199921909600595 0.399316512093575 no 1311 0.420770827479486 1991 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2977 9011197 71.43 µM 0.19932777050818 0.399546424745803 no 1312 0.421003178644266 2021 2704722
SGTC_357 1325-0123 420 µM 0.198845723300275 0.399732987060349 no 1313 0.421191714035669 2067 1098503
SGTC_1548 st061468 90.8 µM 0.198473301409119 0.399877137770692 no 1314 0.421337385812638 2058 390799
SGTC_403 arphamenine a 50 µM 0.1973988921693 0.400293078167523 no 1315 0.421757698242991 1972 5487158 An arginine aminopeptidase inhibitor.
SGTC_965 1291-5240 308 µM 0.196297392544751 0.400719623604663 no 1316 0.422188701069459 2032 2834598
SGTC_65 0798-0905 34.986 µM 0.196241983309372 0.400741083445405 no 1317 0.422210384466512 2076 3602145
SGTC_482 fipronil 114 µM 0.195250337754612 0.401125195570858 no 1318 0.422598486736556 2068 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1680 diphenhydramine 100 µM 0.195077454773994 0.401192171278692 no 1319 0.422666155991863 1912 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_74 000s-0487 160.283 µM 0.194427559596803 0.401443969790356 no 1320 0.422920556101991 2106 677548
SGTC_1039 k821-0043 94 µM 0.194416458328346 0.401448271275021 no 1321 0.422924901949899 2042 15992768
SGTC_1206 3978-0017 132 µM 0.193328042080597 0.401870065294751 no 1322 0.423351033085732 1995 3873677
SGTC_2213 7173844 200 µM 0.192694955954209 0.402115457824075 no 1323 0.423598936994112 1955 892728
SGTC_2908 7930301 100 µM 0.192460874047751 0.402206200833865 no 1324 0.423690606466797 2007 2223178
SGTC_300 r073-0011 5.04 µM 0.192130856832648 0.402334142593649 no 1325 0.423819852449664 2106 2735780
SGTC_2394 5221648 200 µM 0.191313939839857 0.402650891650967 no 1326 0.424139820193655 2034 788586
SGTC_1305 1181-0477 144 µM 0.190102176231808 0.403120855065688 no 1327 0.424614532396129 2083 6252086
SGTC_906 1165-0455 526 µM 0.188970868953859 0.40355974112213 no 1328 0.425057824307355 1944 3252859
SGTC_2798 7813637 45.45 µM 0.188816158988177 0.40361976967811 no 1329 0.425118453303382 1990 956368
SGTC_1420 4'-methoxyflavone 42 µM 0.18762896143036 0.40408048615003 no 1330 0.425583760748488 2080 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2710 st078562 53.7235 µM 0.187487270885128 0.404135480987011 no 1331 0.42563930154723 2035 17250908
SGTC_2804 7954240 19.48 µM 0.187127619270318 0.40427508230671 no 1332 0.425780286793476 2056 828705
SGTC_2452 5863136 48.41 µM 0.187030074113233 0.404312947251961 no 1333 0.425818526623354 1997 2184096
SGTC_2270 7924575 90.91 µM 0.184676543276338 0.405226808546571 no 1334 0.426741372722812 2108 1262135
SGTC_3252 9135871 49.47 µM 0.18387541632475 0.405537999317503 no 1335 0.427055595447412 2046 17682838
SGTC_537 1334-0398 209 µM 0.183450638632628 0.405703024742246 no 1336 0.427222223043768 2100 5846986
SGTC_836 0330-0104 1.35 µM 0.182862469122926 0.405931555280794 no 1337 0.427452965799723 2087 46494820
SGTC_2296 7971656 126.45 µM 0.18279451115688 0.405957962101254 no 1338 0.427479627756402 1964 666570
SGTC_1061 3448-9325 110 µM 0.182328157088528 0.406139187539517 no 1339 0.427662601430779 2122 723482
SGTC_2963 9082507 9 µM 0.181444201756025 0.406482748210733 no 1340 0.428009463316446 2026 16459611
SGTC_793 0488-0545 106 µM 0.180553657724758 0.406828942476307 no 1341 0.428358966851285 1916 292548
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.180259060790328 0.406943481513295 no 1342 0.428474596954893 2127 6708630 An antioxidant.
SGTC_2238 6671620 73.2395 µM 0.179854698423203 0.407100710215819 no 1343 0.428633320288206 2102 729941
SGTC_1018 4259-0013 28.1 µM 0.176950516345539 0.408230385235597 no 1344 0.429773629170753 1979 6801262
SGTC_731 3966-0296 387 µM 0.175280212602461 0.40888044989409 no 1345 0.430429729563072 2010 660956
SGTC_1151 3909-8316 15.3 µM 0.174857882257571 0.409044856207937 no 1346 0.43059565270646 1997 800431
SGTC_2829 7992743 58.44 µM 0.173996532524092 0.409380215179226 no 1347 0.430934093655412 2148 16462845
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.173741133020967 0.409479665497765 no 1348 0.431034454815107 2057 2333 A French combination drug.
SGTC_89 0302-0250 142.109 µM 0.172546062920362 0.409945092577232 no 1349 0.431504125688747 2138 4203518 YLR208W SEC13
SGTC_2713 st079149 53.4 µM 0.171180621171311 0.410477027202367 no 1350 0.432040872324097 2011 3103253
SGTC_2520 obtusaquinone 4.71 µM 0.171066068794523 0.410521660831333 no 1351 0.432085907867178 2097 5967872
SGTC_1981 st071826 47 µM 0.169610728468981 0.411088813228981 no 1352 0.432658142353816 1999 11838600
SGTC_51 1013-0126 23.419 µM 0.169586637052116 0.411098203325317 no 1353 0.432667616202575 2161 1627850
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.168994469860943 0.411329027958369 no 1354 0.432900495625023 2075 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1463 k081-0032 34.1 µM 0.167632236841411 0.411860137880253 no 1355 0.433436304358884 2052 977755
SGTC_1632 st005650 90 µM 0.166279906028669 0.41238754687038 no 1356 0.433968339285371 2007 2759605
SGTC_3064 1327-0027 10 µM 0.165347810913196 0.412751156130985 no 1357 0.434335114504498 2045 16000455 YPR107C YTH1
SGTC_2421 5690543 90.72 µM 0.165244711423589 0.412791379731178 no 1358 0.434375687166088 2006 3397993
SGTC_3296 9122258 64.045 µM 0.16483848840175 0.412949873928401 no 1359 0.434535554517693 2004 4730474
SGTC_2374 9071832 200 µM 0.162167228906071 0.413992459474008 no 1360 0.435587082857352 2115 17381698
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.159723960116395 0.414946592112699 no 1361 0.436549262884864 2051 5106787 A p450 inhibitor.
SGTC_3048 9093155 49.47 µM 0.158706680945742 0.415344003011633 no 1362 0.436949987132133 2139 25236002
SGTC_1066 ketoconazole 628 nM 0.158037555426806 0.415605451245757 no 1363 0.43721360280265 2086 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_262 fenpropimorph 62.5 µM 0.15778367439745 0.415704660275862 no 1364 0.437313631723428 2115 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3097 9117246 49.47 µM 0.157604113457397 0.415774830506471 no 1365 0.43738438100858 2137 16423892
SGTC_112 phenothiazine 287.218 µM 0.155383889578546 0.416642688201554 no 1366 0.438259342080636 2142 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2231 micatex 6.853 µM 0.154887530253242 0.416836764583158 no 1367 0.438454992212601 2061 20737 An antifungal of unknown mechanism.
SGTC_2717 st081029 62.2815 µM 0.152901817234968 0.417613380209187 no 1368 0.439237851408101 2148 5292846
SGTC_1124 fisetin 1.16336 µM 0.152385313111829 0.417815438624221 no 1369 0.439441520117109 1963 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_270 tamoxifen 5.46 µM 0.151685545559359 0.418089225005886 no 1370 0.439717479108559 2157 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2017 5132927 60.65 µM 0.150432370019738 0.418579633224854 no 1371 0.440211752129772 2040 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.150004603327663 0.418747061215681 no 1372 0.440380491712768 2037 15053
SGTC_2313 7726885 200 µM 0.147598138846198 0.419689225490054 no 1373 0.441329961999381 2040 726423
SGTC_380 3970-0968 6 µM 0.147507759823296 0.419724619139673 no 1374 0.441365627638048 2050 2891601
SGTC_716 1683-5115 658 µM 0.147395273397925 0.419768671254595 no 1375 0.441410018029727 2162 723597
SGTC_1330 1469-0054 61.8 µM 0.146852415597234 0.419981280224152 no 1376 0.44162425573062 2166 7102664
SGTC_1588 farnesol 29.9 µM 0.145872400918274 0.420365159745977 no 1377 0.442011059690259 2002 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_159 3970-0959 50 µM 0.143784934300256 0.421183089080146 no 1378 0.442835149966776 2118 6615653
SGTC_2947 9072639 7.68 µM 0.142258580455153 0.421781373901092 no 1379 0.443437880863276 2046 16488146
SGTC_959 1222-0044 107 µM 0.141641975611756 0.422023115752265 no 1380 0.443681404712459 2191 6083612
SGTC_53 0973-0023 39.979 µM 0.141205586487424 0.422194221230585 no 1381 0.443853766459452 2205 674768
SGTC_1376 2910-0861 41.3 µM 0.141123860627342 0.422226267068843 no 1382 0.443886047116685 2132 1112859
SGTC_3238 9133470 49.47 µM 0.141090045221291 0.422239526707104 no 1383 0.443899403873425 2164 3534688
SGTC_604 1000-0114 314 µM 0.141068752838633 0.422247875884412 no 1384 0.443907814190332 2149 1572745
SGTC_2532 xanthone 78.9 µM 0.140049948557918 0.422647410577477 no 1385 0.444310262998336 2125 7020 An insecticide.
SGTC_971 1315-0384 26.7 µM 0.139392934700009 0.422905107633205 no 1386 0.444569827574355 2015 6769120
SGTC_630 4356-0227 183 µM 0.139133302107939 0.423006951046751 no 1387 0.44467240643554 2144 779312
SGTC_1627 st003713 25.6 µM 0.138184673894786 0.423379103401115 no 1388 0.445047233675895 2037 16195070 YER133W GLC7
SGTC_2989 9073649 71.4286 µM 0.137744313661607 0.423551882531168 no 1389 0.445221247972775 2200 21367202
SGTC_1073 triclabendazole 3.09 µM 0.136969042549071 0.423856102530936 no 1390 0.445527632459111 2056 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_632 0781-2353 4.65 µM 0.135586189323802 0.424398853148923 no 1391 0.446074211972405 2100 6811515 YHR007C ERG11
SGTC_2867 9039098 71.43 µM 0.134630809781493 0.424773910121858 no 1392 0.446451890343823 2147 6463460
SGTC_2069 5228469 200 µM 0.13445274079571 0.424843822880199 no 1393 0.446522289533768 2064 2835210
SGTC_2024 5144227 134 µM 0.133821099040424 0.425091834681038 no 1394 0.446772021319373 2138 3475211
SGTC_507 nimesulide 162 µM 0.133762914355635 0.425114682175385 no 1395 0.446795026823296 2158 4495 A COX2 inhibitor.
SGTC_790 1575-0012 79.1 µM 0.132805129927723 0.425490813357948 no 1396 0.447173748602451 2188 378741 YLR208W SEC13
SGTC_899 1083-0020 478 µM 0.13185955194293 0.425862217483201 no 1397 0.447547691038257 2146 767123
SGTC_866 0495-0101 262 µM 0.131333386118514 0.426068913404656 no 1398 0.447755791105958 1961 635694
SGTC_3158 9100007 49.47 µM 0.130917371905054 0.426232352389967 no 1399 0.447920336083714 2053 19297233
SGTC_1249 0481-0015 10.2 µM 0.130329566020465 0.426463304547905 no 1400 0.448152844627651 2099 4227577
SGTC_2911 7942208 15.64 µM 0.127948400754383 0.427399134642531 no 1401 0.449094903764348 2040 1243384
SGTC_2075 5212009 200 µM 0.127278148781522 0.427662626648617 no 1402 0.449360127192277 2168 780898
SGTC_1522 st012842 45.6 µM 0.126780176787795 0.42785841219187 no 1403 0.449557192875488 2027 3491067 YOR116C RPO31
SGTC_1992 st073643 23.3 µM 0.125583683546768 0.428328904907015 no 1404 0.450030739666274 2182 3161292
SGTC_88 0180-0332 8.668 µM 0.125279808000683 0.428448413042129 no 1405 0.450151018556476 2195 3101745
SGTC_43 0570-0105 72.5 µM 0.125266548235902 0.428453627990182 no 1406 0.450156267091675 2122 1114046 YDL195W SEC31
SGTC_1334 1486-0610 236 µM 0.125163359119217 0.428494211782727 no 1407 0.450197112134491 2123 3742339
SGTC_102 gallobenzophenone 83.616 µM 0.124514748895172 0.428749324420397 no 1408 0.450453861662849 2181 70837
SGTC_535 2293-4129 48.2 µM 0.122933464342275 0.429371402903646 no 1409 0.45107989294466 2183 396118 YIL048W NEO1
SGTC_1301 naphtanilide LB 4.81 µM 0.121973465985365 0.429749152634068 no 1410 0.451460016207614 2194 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_533 1222-0222 6.71 µM 0.120825340703506 0.430201012863241 no 1411 0.451914689083634 2186 3982874
SGTC_1946 st076057 65.1 µM 0.120751721455473 0.430229989839087 no 1412 0.451943845442901 2152 953009
SGTC_2585 alliin 100 µM 0.118245661884578 0.431216612956657 no 1413 0.452936505381396 2141 87310 A garlic compound which reacts with lipids.
SGTC_2111 5486399 200 µM 0.117371854231407 0.431560727926391 no 1414 0.45328269347783 2173 689674
SGTC_1155 4088-0394 48.2 µM 0.116959028235513 0.431723321383369 no 1415 0.453446260655118 2037 2326248
SGTC_1358 1509-0022 2.48 µM 0.113662154925588 0.433022223235268 no 1416 0.454752807017315 2114 3258434
SGTC_47 0149-0135 24.25 µM 0.113648604611927 0.433027563290028 no 1417 0.45475817800807 2200 5239155
SGTC_2793 7325131 81.82 µM 0.111615347000394 0.433828989584791 no 1418 0.455564201458015 2137 4176441
SGTC_3232 9132874 49.47 µM 0.111563130867399 0.433849574628627 no 1419 0.455584903387254 2072 3784940
SGTC_748 act1.228 77.9 µM 0.110981626534247 0.4340788318321 no 1420 0.45581545830879 2122 4421505 YNR035C ARC35
SGTC_181 1447-1644 8.07 µM 0.108790549691696 0.434942859127108 no 1421 0.456684309790804 2206 534600
SGTC_920 mycophenolic acid 780.421 nM 0.10802069454281 0.435246517111299 no 1422 0.4569896381948 2124 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1491 4138-0063 26.5 µM 0.107874633012687 0.435304133238527 no 1423 0.457047569799708 2230 23883227
SGTC_409 arachidonic acid 100 µM 0.107861891270632 0.435309159471972 no 1424 0.457052623532139 2216 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_879 0831-1030 162 µM 0.107633454105872 0.435399272825308 no 1425 0.457143229299331 2189 1549252
SGTC_1483 3453-0561 55.9 µM 0.10750164820703 0.43545126883162 no 1426 0.457195508910651 2182 4546991
SGTC_2583 asiatic acid 100 µM 0.106814921916252 0.435722192985088 no 1427 0.457467904613477 2159 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_140 0062-0056 502.533 µM 0.106807641615803 0.435725065338162 no 1428 0.457470792512551 2219 3758964
SGTC_1730 st033808 45.1 µM 0.106185412000334 0.43597057089936 no 1429 0.457717622521559 2035 1045166
SGTC_784 4579-0127 173 µM 0.105930240648871 0.436071257891224 no 1430 0.45781885024019 2223 1948547
SGTC_3197 9113331 49.47 µM 0.103558040835829 0.437007491700047 no 1431 0.458760043562697 2182 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1303 1160-0052 261 µM 0.102863156679927 0.43728180802063 no 1432 0.459035789626235 2227 3562476
SGTC_1360 1598-0022 39.8 µM 0.102787227277742 0.43731178416202 no 1433 0.459065921361571 2192 761525
SGTC_1506 4226-2149 212 µM 0.102606928473638 0.437382965703535 no 1434 0.459137471870432 2122 991114
SGTC_1860 st056228 74.6 µM 0.102002378925382 0.437621655214105 no 1435 0.459377393412782 2104 688679
SGTC_2740 felodipine 17.08 µM 0.101157887519816 0.437955117053849 no 1436 0.45971256303374 2240 3333 L-type calcium channel blocker
SGTC_2985 9022375 71.43 µM 0.100930393969701 0.438044954307261 no 1437 0.459802857700047 2136 4939335
SGTC_1808 st050063 61.5 µM 0.100414826785332 0.438248563714153 no 1438 0.460007499593852 2229 4011993
SGTC_3214 9129694 49.47 µM 0.100219255364406 0.438325803671664 no 1439 0.460085129702346 2207 17158655
SGTC_1936 st074407 74.3 µM 0.100137059644443 0.438358267162777 no 1440 0.460117756920966 2196 809813
SGTC_1054 3429-0080 167 µM 0.0986082567589377 0.438962148656711 no 1441 0.46072465701521 2206 1162877
SGTC_2287 7945887 168.79 µM 0.0984728815666744 0.439015629112348 no 1442 0.460778402328559 2210 1245853
SGTC_600 1495-0418 41.6 µM 0.0976665416755166 0.439334199612309 no 1443 0.461098542187852 2163 5377768
SGTC_1298 1079-1278 263 µM 0.0970455800085378 0.43957955727729 no 1444 0.461345098817437 2167 2840950
SGTC_2702 st077768 96.8 µM 0.0963646417035647 0.439848639908004 no 1445 0.461615486614979 2126 6484119
SGTC_443 clozapine 122 µM 0.0956947669752663 0.44011337772217 no 1446 0.461881498587814 2244 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2145 5634607 200 µM 0.0946019742021176 0.44054531226291 no 1447 0.462315490842206 2166 308662
SGTC_1895 st058434 18.3 µM 0.0935104163340681 0.440976829332153 no 1448 0.46274903745854 2256 5393175
SGTC_1624 st003710 6.25 µM 0.0933097530655567 0.441056163620583 no 1449 0.462828742031821 2218 24207033
SGTC_2193 5925765 200 µM 0.0916196588446511 0.441724453321142 no 1450 0.46350011582202 2213 877370
SGTC_615 k087-0205 167 µM 0.0916182609179953 0.441725006152154 no 1451 0.46350067117833 2193 9642773
SGTC_2682 pyrogallin 40.03 µM 0.0904219079937404 0.442198163324017 no 1452 0.463975973970392 2252 822798 An ATP competetive kinase inhibitor.
SGTC_1244 0416-0015 52.5 µM 0.0903031110932629 0.442245151969895 no 1453 0.464023173979756 2166 96201
SGTC_835 0312-0010 67.2 µM 0.0902927627128138 0.44224924518238 no 1454 0.464027285589583 2222 1626196
SGTC_2464 5717415 7.67 µM 0.0901676734521548 0.442298723646342 no 1455 0.464076986253313 2209 5285744
SGTC_2320 7373003 200 µM 0.0880479965860245 0.443137288024626 no 1456 0.464919264241802 2161 5415828
SGTC_410 α-linolenic acid 100 µM 0.0875604620180553 0.443330197519354 no 1457 0.465113014085634 2208 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2463 5473429 200 µM 0.0849452820518608 0.44436520982629 no 1458 0.46615244599286 2166 5399405
SGTC_1119 parthenolide 318.541 nM 0.0845125691718031 0.444536501802581 no 1459 0.466324454919947 2195 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1445 4239-0156 97.7 µM 0.083618912519429 0.444890293875535 no 1460 0.466679714791076 2253 4008346
SGTC_949 1165-0505 146 µM 0.0830906315757727 0.445099457068542 no 1461 0.466889737503379 2168 6244267
SGTC_2217 6934799 96.0675 µM 0.0826829456769723 0.445260883308286 no 1462 0.467051822905852 2258 675606
SGTC_2153 5569715 200 µM 0.0825438662194823 0.445315954923432 no 1463 0.467107118563671 2263 2054701
SGTC_2686 alizarin 95.37 µM 0.0819617747377619 0.445546458475742 no 1464 0.467338555242377 2166 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1283 0922-0125 16.4 µM 0.0819564287887028 0.445548575514066 no 1465 0.46734068081643 2235 3360884
SGTC_2073 5212005 126 µM 0.0818964995803198 0.445572308063231 no 1466 0.467364509010378 2285 691789
SGTC_119 0121-0043 24.815 µM 0.0810890328015964 0.445892091741203 no 1467 0.467685573760861 2255 1092378
SGTC_2022 5136654 200 µM 0.0808683808165002 0.445979483392557 no 1468 0.46777331301734 2186 1713771
SGTC_2553 4-methylesculetin 85.09 µM 0.0806261333687928 0.446075431187065 no 1469 0.467869641218179 2239 5319502
SGTC_2150 5556613 200 µM 0.0804539928535491 0.446143613402945 no 1470 0.467938092974309 2193 743190
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.0802493593810257 0.446224667652054 no 1471 0.468019466803214 2270 23665772 A membrane-active detergent.
SGTC_3187 9109394 49.47 µM 0.0796153588928486 0.446475806183267 no 1472 0.468271589682169 2181 17098090
SGTC_2174 5790901 200 µM 0.0788580798829387 0.446775805593513 no 1473 0.46857275338283 2194 786020
SGTC_801 0866-0028 10.1 µM 0.0782601331393025 0.447012706356454 no 1474 0.468810564653306 2263 6849771
SGTC_2616 abietic acid 100 µM 0.0781476982262653 0.447057254104787 no 1475 0.468855282739986 2292 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1191 1487-1166 10.6 µM 0.0778272303536863 0.447184230091621 no 1476 0.468982742724708 2212 3955771
SGTC_182 3448-4371 550.524 µM 0.0773491458477013 0.447373667101283 no 1477 0.469172897624389 2272 3491403
SGTC_826 1683-5028 118 µM 0.0772808448326071 0.447400731791658 no 1478 0.469200064469257 2197 722377
SGTC_3207 9114163 49.47 µM 0.0766974804363139 0.447631903429184 no 1479 0.469432104479499 2271 849233
SGTC_621 3584-0052 32.1 µM 0.076148873387176 0.447849317896504 no 1480 0.469650328822744 2269 2273927
SGTC_1753 st043925 64 µM 0.0761317109297327 0.447856119678203 no 1481 0.469657155834676 2252 670181
SGTC_3307 9126885 69.2785 µM 0.0758609371532521 0.447963434083905 no 1482 0.469764867451619 2224 24824909
SGTC_1836 st055642 81 µM 0.0749734905437585 0.448315177980209 no 1483 0.470117901998025 2219 8571
SGTC_1907 st060210 83.7 µM 0.0749113691606775 0.448339801625747 no 1484 0.470142615347085 2236 688793
SGTC_1231 0242-0792 125 µM 0.0747016050567002 0.448422949295934 no 1485 0.47022606529656 2208 3707635
SGTC_553 k007-0256 45.7 µM 0.0741964534776996 0.448623193880459 no 1486 0.470427033894744 2189 6287000
SGTC_1969 st069479 40.1 µM 0.0738102905895009 0.448776279589868 no 1487 0.470580669328356 2273 3895485
SGTC_2645 abamectin 100 µM 0.0729986861198032 0.449098047007346 no 1488 0.470903581523706 2267 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2603 homopterocarpin 100 µM 0.0726421083568531 0.449239425858495 no 1489 0.471045458795586 2213 101795 A weak amylase inhibitor.
SGTC_474 dl-dihydrosphingosine 5 µM 0.0725118466066641 0.449291074704641 no 1490 0.471097289029558 2243 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_341 1486-1430 230 µM 0.0717899515934152 0.449577321973184 no 1491 0.471384534827021 2283 2054753 YPL210C SRP72
SGTC_1713 st033146 12.748 µM 0.0705270815174977 0.45007814078298 no 1492 0.471887073139656 2276 674619
SGTC_3355 9151058 44.0485 µM 0.0701345443290976 0.450233826245387 no 1493 0.472043285994137 2292 17015728
SGTC_3028 9087778 49.47 µM 0.0689825522409225 0.450690765738928 no 1494 0.472501753853304 2271 17217395
SGTC_2254 7938975 95.19 µM 0.0688821072100912 0.450730610526815 no 1495 0.472541730532112 2274 2969277
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.0683782717821634 0.450930480717428 no 1496 0.472742258973235 2292 756377
SGTC_2539 epi(13)torulosol 80 µM 0.0673474731853828 0.451339434527464 no 1497 0.473152542256326 2210 6708597
SGTC_2627 acetyl isogambogic acid 100 µM 0.0669841285308309 0.451483598378218 no 1498 0.473297169208602 2203 6857789 A caspase activator and apoptosis inducer.
SGTC_485 niflumic acid 177 µM 0.0668313124893603 0.451544232940116 no 1499 0.473357997682434 2266 4488 A COX2 inhibitor.
SGTC_2902 5787006 60.46 µM 0.0656474340027355 0.452014012092497 no 1500 0.4738292618311 2247 591003
SGTC_2652 actinonin 100 µM 0.0649976658726826 0.452271877563956 no 1501 0.474087929345226 2311 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1462 k081-0014 26.5 µM 0.0626688129404762 0.4531962653737 no 1502 0.47501511611422 2280 3270634
SGTC_2819 7996655 46.38 µM 0.0615170758996917 0.453653516547234 no 1503 0.475473707779897 2288 6456960
SGTC_2923 7992654 58.14 µM 0.060718204060044 0.453970712818753 no 1504 0.47579181684287 2254 2985126
SGTC_619 1652-1634 108 µM 0.0594697587256981 0.454466473335378 no 1505 0.476288975936352 2226 5400454
SGTC_2700 st077718 96.8 µM 0.0593779516729889 0.454502932936973 no 1506 0.476325537042095 2236 904970
SGTC_1504 k297-0033 30 µM 0.0592504218362627 0.454553579867598 no 1507 0.476376324667499 2289 4388117
SGTC_1185 1319-0113 81.3 µM 0.0562043558050034 0.455763505846396 no 1508 0.47758950560973 2241 4672763
SGTC_2933 9026794 32.47 µM 0.0551022280830446 0.456201382998679 no 1509 0.478028510544976 2274 17586027
SGTC_1719 st032227 49.2 µM 0.0543873318817097 0.456485440910799 no 1510 0.478313285805405 2272 3125804
SGTC_2876 9059903 25.97 µM 0.0533939180698436 0.456880202313766 no 1511 0.478709025489726 2305 6916095
SGTC_1857 st056007 79.3 µM 0.0531407464366206 0.456980814126437 no 1512 0.478809883169373 2312 619834
SGTC_1364 1653-0028 37.6 µM 0.0523174344884238 0.457308021897788 no 1513 0.479137880813856 2266 5718652
SGTC_3209 9113616 49.47 µM 0.0517418126338684 0.457536807729683 no 1514 0.479367210089286 2327 16649353
SGTC_3321 9137793 26.8275 µM 0.0510939344111901 0.457794329302677 no 1515 0.479625334660154 2329 4904192
SGTC_301 4119-0100 24.5 µM 0.0502082337246909 0.458146410276034 no 1516 0.479978225133839 2291 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2300 7976697 71.57 µM 0.0496355208134727 0.458374090827098 no 1517 0.480206419995389 2269 2236109
SGTC_714 4296-0578 26.1 µM 0.049633883865324 0.458374741611252 no 1518 0.480207072239286 2307 1589775
SGTC_1568 digitonin 820 nM 0.0482724819073467 0.458916018249752 no 1519 0.480749542617698 2324 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_984 1492-0255 2.91 µM 0.0478395264988272 0.459088171996755 no 1520 0.480922067506556 2261 1585198
SGTC_1478 0453-0656 35.7 µM 0.0473228317609305 0.459293632605341 no 1521 0.481127965675813 2316 5258496
SGTC_2926 9010726 65.15 µM 0.0446542625939231 0.460354945247542 no 1522 0.482191445233491 2281 2994293
SGTC_1254 0550-0035 264 µM 0.0445813935539909 0.46038392988087 no 1523 0.482220486852744 2302 15121435
SGTC_2491 paeonol 100 µM 0.0443463426160206 0.460477425962885 no 1524 0.482314165960484 2256 11092 Increases levels of cortical cytochrome oxidase.
SGTC_523 1934-0222 13.7 µM 0.0442153209283722 0.460529543336161 no 1525 0.482366384831022 2320 1361595
SGTC_1423 4048-0112 5.59 µM 0.0437994089287896 0.460694987923028 no 1526 0.482532149120095 2331 X1423
SGTC_1557 sumaresinolic acid 42.3 µM 0.0435096595585052 0.460810250618221 no 1527 0.482647632302564 2316 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2206 7254556 146.969 µM 0.0430417629122234 0.460996387490549 no 1528 0.482834121346993 2322 4398905
SGTC_1183 1254-0324 198 µM 0.0427007012526511 0.46113207273584 no 1529 0.482970060281169 2311 5799357
SGTC_2658 polymyxin b sulfate 77.05 µM 0.04224752735351 0.461312366816445 no 1530 0.483150687504554 2316 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_3020 9089140 49.47 µM 0.0417434522874377 0.461512921136634 no 1531 0.48335160710761 2300 17217859
SGTC_2255 7941087 197.44 µM 0.0407177876982048 0.461921028349016 no 1532 0.48376044041118 2350 935561
SGTC_1739 st037196 92.5 µM 0.0401046080203486 0.46216502889459 no 1533 0.484004864044999 2323 612214
SGTC_2417 cerulenin 830 nM 0.0384988979250359 0.462804050994502 no 1534 0.484644955081229 2346 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_661 1304-0007 33.6 µM 0.037665668598389 0.463135687990867 no 1535 0.484977124525867 2313 3117130
SGTC_2893 9048488 25.97 µM 0.0375313741526205 0.463189141473581 no 1536 0.485030662403012 2311 6467338
SGTC_1902 st060212 70.5 µM 0.0370719423892219 0.463372015023537 no 1537 0.485213821687276 2345 688944
SGTC_872 0588-0139 234 µM 0.0356863874807385 0.463923572027631 no 1538 0.485766212427959 2349 2047100
SGTC_2759 disulfiram 3.38 µM 0.0349860358013326 0.464202392102049 no 1539 0.486045437936725 2325 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2057 5236571 38.335 µM 0.0348157842094174 0.464270174370563 no 1540 0.486113317141441 2327 54684039 YBR257W POP4
SGTC_679 0422-0091 41.4 µM 0.0340658331134933 0.464568764728485 no 1541 0.486412326944113 2348 627384 YHR062C RPP1
SGTC_1970 st070122 35.8 µM 0.03360500027706 0.464752253589805 no 1542 0.486596067438717 2322 102928
SGTC_2343 7990716 14.84 µM 0.0334372480285377 0.464819049020056 no 1543 0.486662953313964 2326 6456862
SGTC_1756 st041558 35.5 µM 0.033247446961616 0.464894625023092 no 1544 0.486738630906768 2352 3955792
SGTC_2027 5150920 200 µM 0.0332305914340313 0.4649013367084 no 1545 0.486745351575748 2320 786715
SGTC_2441 5730946 39.09 µM 0.0324932354298119 0.465194953489092 no 1546 0.487039355263938 2330 1774275
SGTC_2505 galangin 7.89 µM 0.0304028806962272 0.46602743982002 no 1547 0.487872873727905 2344 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2600 tangeritin 87.95 µM 0.0302200848093532 0.466100245627306 no 1548 0.487945765242218 2352 68077 A bioactive flavone.
SGTC_2998 9066762 71.4286 µM 0.0293880697225327 0.466431643366349 no 1549 0.488277543839341 2333 4945196
SGTC_3248 9135562 49.47 µM 0.0287020854067408 0.466704893489479 no 1550 0.488551096570099 2339 17650701
SGTC_824 1304-0008 100 µM 0.0284640377232086 0.466799719388479 no 1551 0.488646025069782 2331 768245
SGTC_799 1310-0557 151 µM 0.0260338985814634 0.467767868150685 no 1552 0.489615150224758 2283 5354492
SGTC_347 4534-1311 26.2 µM 0.0254114792140588 0.468015866147033 no 1553 0.489863377488347 2364 2862016
SGTC_44 0929-0055 61.211 µM 0.0249994707960352 0.468180034425227 no 1554 0.490027692860635 2328 1379590
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.0247156753969945 0.468293118278557 no 1555 0.490140875870682 2305 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1802 st050112 57.9 µM 0.0245083562285798 0.468375730292731 no 1556 0.49022355920579 2354 4662563
SGTC_1013 4112-3890 241 µM 0.0224233465758489 0.469206634750719 no 1557 0.491055128578953 2338 705171
SGTC_608 k048-0125 159 µM 0.0221715443358633 0.469306990487494 no 1558 0.49115555816982 2371 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2431 5490079 200 µM 0.0213404122150137 0.469638251848465 no 1559 0.491487053442503 2358 5722345
SGTC_2925 9010536 32.5 µM 0.0213167751572131 0.469647673094599 no 1560 0.491496481119632 2340 2994177
SGTC_642 0335-0876 158 µM 0.0196159154126019 0.470325645160604 no 1561 0.49217488380645 2360 6812350
SGTC_2992 9074591 71.4286 µM 0.0193723185457111 0.470422751302599 no 1562 0.492272046432133 2374 17741321
SGTC_1006 4099-6547 255 µM 0.0188199593802272 0.470642947289867 no 1563 0.492492365679662 2355 3146833
SGTC_998 3996-0085 177 µM 0.0185280574341103 0.470759316576427 no 1564 0.492608797404563 2346 715391
SGTC_1103 duloxetine 36.1 µM 0.0174614981015216 0.471184531020704 no 1565 0.49303422411201 2357 60835 A selective serotonin reuptake inhibitor.
SGTC_1397 3532-0190 20.1 µM 0.0173310941976617 0.471236522537824 no 1566 0.493086239871363 2375 5322280
SGTC_2006 4011487 200 µM 0.0170331176200498 0.471355326451089 no 1567 0.493205097780108 2369 45595294
SGTC_2077 5212015 200 µM 0.0169801103868582 0.471376460818275 no 1568 0.493226241548719 2372 780900
SGTC_1695 st026914 34.495 µM 0.0166677305567072 0.471501010550747 no 1569 0.493350845434547 2369 3289191
SGTC_2508 celastrol 40.54 µM 0.015322962086824 0.472037218178256 no 1570 0.493887261768375 2382 122724 Celastrol is a natural product and antioxidant.
SGTC_699 0375-0592 111 µM 0.0153122241090403 0.472041500002051 no 1571 0.493891545099194 2379 762578
SGTC_572 0960-0087 17.7 µM 0.014664811389085 0.472299665101912 no 1572 0.494149796391107 2368 6796365
SGTC_2277 7947813 106.88 µM 0.0145360731719915 0.472351002701508 no 1573 0.494201150035079 2357 1246798
SGTC_1461 k072-0203 53.8 µM 0.0138551901759024 0.472622529527363 no 1574 0.494472755677165 2372 5418714
SGTC_1862 st057513 3.81 µM 0.0126735090196855 0.473093797937436 no 1575 0.494944136754992 2381 5393163
SGTC_588 3970-1144 52.9 µM 0.0124172643739936 0.473195996322224 no 1576 0.495046355533749 2373 1888707
SGTC_2318 6029776 164 µM 0.0118671760060053 0.473415394730932 no 1577 0.495265792862126 2376 818325
SGTC_1596 piperlongumine 63 µM 0.00938894571737104 0.474403916388383 no 1578 0.496254407615459 2386 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_173 1273-0061 2.693 µM 0.00614552454708981 0.475697896156088 no 1579 0.497548305855312 2387 2847414 YPL266W DIM1
SGTC_1921 5740136 50 µM 0.00604437211385276 0.475738255638969 no 1580 0.497588659088143 2398 1774243
SGTC_355 1311-2252 105 µM 0.00534500108844097 0.476017309129333 no 1581 0.497867663230169 2392 5338538
SGTC_2401 5128683 200 µM 0.00367509082400981 0.476683661273161 no 1582 0.498533854186354 2394 708373
SGTC_117 lucigenin 22.078 µM 0.003218773434927 0.476865759167983 no 1583 0.4987158974031 2394 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_211 3455-0679 143.504 µM 0.00158003667003803 0.477519752577837 no 1584 0.499369656830014 2373 748649
SGTC_1081 sertraline 6 µM 0.000860458956270986 0.47780694367056 no 1585 0.499656726584153 2402 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_917 harmaline 728.087 nM 0.000674650201429598 0.477881103792342 no 1586 0.499730853530586 2402 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1055 3448-0672 86 µM 3.04609610021281e-05 0.478138218972463 no 1587 0.499987847834756 2404 748378
SGTC_2083 5306046 65.942 µM 0 0.478150377078597 no 1588 0.5 2405 539837
SGTC_1361 1608-0041 5.61 µM -0.00160860616551027 0.478792460434986 no 1589 0.499358259264826 2408 X1361
SGTC_259 usnic acid 108.925 µM -0.00180556936536553 0.478871083116847 no 1590 0.49927968243134 2411 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1108 betulinic acid 729.144 nM -0.00411113878683957 0.479791467909754 no 1591 0.498359897537354 2415 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2235 salicylic acid 500 µM -0.00431731176723129 0.479873777617203 no 1592 0.49827764714892 2412 338 A COX inhibitor and kinase inhibitor.
SGTC_1243 0416-0003 5.65 µM -0.00443970624806765 0.479922641137707 no 1593 0.498228819283707 2413 2141977
SGTC_3229 9132204 49.47 µM -0.00454079871321262 0.47996300048692 no 1594 0.49818848963172 2413 17682924
SGTC_2247 cerulenin 830 nM -0.00626882489839355 0.480652915296977 no 1595 0.497499117079627 2422 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2684 capsaicin 100 µM -0.00794298614472515 0.481321379814628 no 1596 0.496831240314313 2427 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3083 9117465 49.47 µM -0.00994955235360515 0.482122637098385 no 1597 0.49603076838327 2457 16420915
SGTC_1109 tnp00067 928.257 nM -0.00998579031015581 0.482137108227312 no 1598 0.496016312248406 2423 676295
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.0100777366519773 0.482173825838326 no 1599 0.495979632810826 2438 5393153
SGTC_2485 5633444 17.78 µM -0.011276936887703 0.482652725047581 no 1600 0.495501248432798 2440 5724239
SGTC_2551 apiole 73.87 µM -0.011396610385641 0.48270051790374 no 1601 0.495453508682568 2423 10659 A possible DNA adduct former.
SGTC_293 4049-0273 38.5 µM -0.0117246319853319 0.482831518013893 no 1602 0.49532265574256 2428 1380311
SGTC_885 0865-0106 16.8 µM -0.0121444604235086 0.482999185198387 no 1603 0.495155180356754 2430 2793380
SGTC_1188 1403-0014 4.57 µM -0.0121785304913238 0.483012791918104 no 1604 0.495141589371311 2428 9614867
SGTC_310 1273-0058 1.06 µM -0.0121967053543228 0.483020050504844 no 1605 0.495134339188505 2431 2734232
SGTC_1377 2944-0135 198 µM -0.0129369433492033 0.483315687843245 no 1606 0.494839050279211 2433 1894137
SGTC_404 fumagillin 50 µM -0.0130409271455379 0.483357217783199 no 1607 0.494797570245641 2434 12015870 A methionine aminopeptidase binder.
SGTC_1372 2752-0194 270 µM -0.0150903918012948 0.48417578682396 no 1608 0.49398003316124 2436 823334
SGTC_2948 9070189 9.45 µM -0.0152063140487828 0.484222088922174 no 1609 0.493933792181327 2439 6473636 YDL196W YDL196W
SGTC_499 genistein 192 µM -0.0155047801471372 0.484341304346507 no 1610 0.493814735473055 2428 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1289 0976-0073 69.1 µM -0.0168253999122764 0.484868812217261 no 1611 0.493287953281942 2464 3391136
SGTC_1663 st014140 55.4 µM -0.0177526498498712 0.485239208468817 no 1612 0.492918089372796 2434 4207120
SGTC_1385 3091-4834 14.1 µM -0.0178812533075372 0.485290581001691 no 1613 0.492866792158799 2452 4072814
SGTC_1394 3474-0001 65.7 µM -0.0180485941342942 0.485357428108838 no 1614 0.49280004359988 2462 5017666 YIL048W NEO1
SGTC_2838 9002687 71.43 µM -0.0185947227202692 0.485575591208817 no 1615 0.492582206384317 2440 6457060
SGTC_291 SEC14.278 35.5 µM -0.0192901143553335 0.485853386963532 no 1616 0.492304835032236 2437 1068044
SGTC_1814 st052110 31.539 µM -0.0198207004891242 0.486065350674342 no 1617 0.492093202262086 2440 674163
SGTC_116 0155-0182 31.788 µM -0.0205760216210976 0.486367100485513 no 1618 0.491791934195427 2449 771486
SGTC_328 k915-0120 63.5 µM -0.021313565526636 0.486661755851405 no 1619 0.491497761286128 2449 6624543
SGTC_1616 st002734 56.1 µM -0.0215038209142102 0.48673776576291 no 1620 0.491421877759987 2460 4026101
SGTC_2750 bromebric acid 70.15 µM -0.021835793252514 0.48687039489671 no 1621 0.491289471050379 2472 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2129 girgensonine 121.053 µM -0.0225600737340437 0.487159763462834 no 1622 0.491000596129814 2470 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_673 1082-0474 110 µM -0.0226519576018413 0.487196473903096 no 1623 0.490963949135164 2449 3098046
SGTC_2100 5377183 190 µM -0.0234750292886356 0.487525321239653 no 1624 0.490635678368045 2482 2844202
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.0235039288927037 0.487536867847218 no 1625 0.490624152274328 2458 1273210
SGTC_1422 4031-0024 15.5 µM -0.0244171040273881 0.487901725058409 no 1626 0.490259952675999 2443 782427
SGTC_2766 oltipraz 83.91 µM -0.0247602975265487 0.488038849935991 no 1627 0.490123079662751 2460 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_464 bw-b 70c 158 µM -0.0252360415037816 0.488228938431912 no 1628 0.489933344570172 2522 5353454
SGTC_155 k072-0202 43.6 µM -0.0269740829673756 0.488923413532812 no 1629 0.489240202651902 2441 5857737
SGTC_889 0919-1524 82.7 µM -0.0271926544083483 0.489010751282848 no 1630 0.489153037237148 2495 3905452
SGTC_3040 9091894 49.47 µM -0.0272977881827794 0.489052761292718 no 1631 0.489111110493491 2477 25236966
SGTC_2555 cholic acid 100 µM -0.0273177784861146 0.489060749156667 no 1632 0.489103138489269 2564 6708657 Influences liver metabolism.
SGTC_1241 0364-0022 50.8 µM -0.02886516659367 0.489679078288658 no 1633 0.488486063534989 2488 4563895
SGTC_2935 9038016 29.96 µM -0.0289706336538926 0.489721223357961 no 1634 0.488444005854435 2455 6463195
SGTC_2814 7977482 42.97 µM -0.0292669160611146 0.489839619634124 no 1635 0.488325856375958 2481 6456762
SGTC_810 3825-7150 143 µM -0.0305544663677108 0.490354142936739 no 1636 0.487812427876599 2464 22330411 YGL099W LSG1
SGTC_2152 5568786 200 µM -0.0307719931142591 0.4904410713079 no 1637 0.487725688047894 2458 5399883
SGTC_2060 5238662 140 µM -0.0308532021726374 0.49047352431263 no 1638 0.487693305696777 2491 790130
SGTC_432 NS 1619 61.3 µM -0.0319614591590501 0.490916415468434 no 1639 0.487251393159484 2590 4552 A K+/calcium channel activator.
SGTC_1336 1486-0901 104 µM -0.0326206170346184 0.491179839134697 no 1640 0.486988564281242 2534 5006114
SGTC_2342 7990637 118.86 µM -0.032850868576271 0.491271857009271 no 1641 0.486896756411515 2489 2033102 YER133W GLC7
SGTC_1950 st077106 7.18 µM -0.033048162492374 0.491350704046833 no 1642 0.486818090241208 2513 13831864
SGTC_2837 9008476 45.46 µM -0.0332938958381195 0.491448910012325 no 1643 0.486720110739227 2522 2992805
SGTC_999 SEC7.066 22.7 µM -0.0334845082492185 0.491525087560006 no 1644 0.486644109765613 2486 740511 YDR170C SEC7
SGTC_416 estradiol valerate 100 µM -0.0344679513080911 0.491918121804685 no 1645 0.486251999153328 2491 13791 A steroid.
SGTC_2724 maprotiline 69.64 µM -0.0344879589886137 0.491926117981886 no 1646 0.486244021986391 2452 4011 A tricyclic antidepressant.
SGTC_3324 9138759 60.749 µM -0.0351834212662629 0.49220406521809 no 1647 0.485966740979808 2540 45595710
SGTC_373 0844-0104 25.9 µM -0.0356452226797153 0.492388630061993 no 1648 0.48578262436583 2480 5375804
SGTC_815 1582-0027 36.9 µM -0.036814932692572 0.492856126836273 no 1649 0.485316283776568 2510 3128206
SGTC_950 1165-0508 94.1 µM -0.0376120534459971 0.493174716912816 no 1650 0.484998498731414 2502 6148369
SGTC_1735 st034310 56.75 µM -0.0386837165016343 0.493603041797461 no 1651 0.484571278020575 2652 871153
SGTC_3246 9135460 32.98 µM -0.0388144145231818 0.49365528001362 no 1652 0.484519176183734 2461 41446951
SGTC_322 k048-0136 19.3 µM -0.0389142051774275 0.493695165050022 no 1653 0.48447939552697 2534 6823282
SGTC_149 3970-0822 46.1 µM -0.0393767888503569 0.49388005459003 no 1654 0.484294992684084 2477 3114250 YBL034C STU1
SGTC_2973 9094665 17.96 µM -0.0396223655229897 0.493978209386648 no 1655 0.484197098164658 2505 25237061 YIL048W NEO1
SGTC_1436 4092-1007 8.32 µM -0.0398175527241009 0.494056224223132 no 1656 0.484119291138986 2483 2881121
SGTC_2482 5981709 142.65 µM -0.0398926003627686 0.494086220252933 no 1657 0.484089375231941 2525 877755
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.0410160246070574 0.494535249170698 no 1658 0.483641560411545 2492 4330530
SGTC_1338 1486-1223 76 µM -0.04197107549141 0.494916985286478 no 1659 0.483260878102557 2532 3444526
SGTC_158 k038-0087 26.446 µM -0.0431296643082753 0.495380082214119 no 1660 0.482799086297869 2488 X158
SGTC_3275 9138069 49.47 µM -0.0444312420762493 0.495900340328767 no 1661 0.482280329327908 2574 17617007
SGTC_1930 st074634 34.3 µM -0.0449406819447892 0.496103972233771 no 1662 0.482077295041453 2489 684253 YOR116C RPO31
SGTC_1523 st012844 44.7 µM -0.0454498933121986 0.496307513817389 no 1663 0.481874356467987 2582 4274103
SGTC_2384 9036245 200 µM -0.0455000554247381 0.496327564632041 no 1664 0.48185436536165 2568 6462766
SGTC_868 0527-0199 213 µM -0.0462819871754545 0.496640119793295 no 1665 0.481542748037487 2541 2849450
SGTC_2575 plumbagin 510 nM -0.0478971986358092 0.497285761328557 no 1666 0.480899085997492 2484 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3295 9122362 53.5725 µM -0.0479004150148534 0.497287047005583 no 1667 0.480897804319019 2532 4730473
SGTC_2407 paclitaxel 400 µM -0.0479295853646457 0.497298707214837 no 1668 0.480886180384204 2755 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_324 1315-0088 19.6 µM -0.0491498539674598 0.497786484842539 no 1669 0.480399936833049 2483 6787421
SGTC_757 1066-0008 322 µM -0.0491654200879986 0.497792707106479 no 1670 0.480393734348023 2629 6842497
SGTC_3109 9122853 49.47 µM -0.049716049052699 0.498012811013962 no 1671 0.480174333490109 2551 1234709
SGTC_517 1365-0151 113 µM -0.0517821913736713 0.498838718649394 no 1672 0.479351122868476 2625 768657
SGTC_3331 9141060 1.957 µM -0.0521250968248679 0.498975790243743 no 1673 0.479214507885246 2511 4906567 YPR165W RHO1
SGTC_1090 efavirenz 20.7 µM -0.0521572047630871 0.498988624943443 no 1674 0.479201716071528 2520 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_3310 9130229 44.1445 µM -0.0531789254461185 0.499397043986677 no 1675 0.478794673454536 2597 7761258
SGTC_3354 9151612 71.43 µM -0.0532759521688176 0.49943582914816 no 1676 0.47875602018679 2527 27261949
SGTC_2046 4110841 106 µM -0.0545054844672009 0.499927318917637 no 1677 0.478266219557128 2520 44119630 YMR134W ERG29
SGTC_315 k915-0449 187 µM -0.0545787076357776 0.499956588951163 no 1678 0.478237051157231 2528 20970215 YNL149C PGA2
SGTC_842 0271-0008 11.1 µM -0.0547959055092374 0.499956588951163 no 1679 0.478150531216903 2609 1221709
SGTC_2708 st078559 56 µM -0.0549256119010227 0.499904740465351 no 1680 0.478098863663741 2502 17250902
SGTC_3027 9089541 49.47 µM -0.0550239057451891 0.499865448748252 no 1681 0.478059709304765 2567 9943819
SGTC_2495 cafestol 54.53 µM -0.0559424506008191 0.499498272210624 no 1682 0.477693826535542 2680 16667697 An anti-infammatory.
SGTC_2390 9097792 176.6 µM -0.0559645812148956 0.499489425785179 no 1683 0.477685011507729 2526 4497149
SGTC_1989 st071868 50.2 µM -0.057178528727658 0.499004166543422 no 1684 0.477201490883109 2500 16414057
SGTC_3087 9117406 49.47 µM -0.0575763586327721 0.498845139658452 no 1685 0.477043040751847 2607 42546093
SGTC_723 4182-0001 115 µM -0.058589055858769 0.498440329134207 no 1686 0.476639713934326 2520 744821 YLR208W SEC13
SGTC_396 dithiazanine 1.25 µM -0.0588269489439308 0.498345235159649 no 1687 0.476544971736057 2518 10578 An antihelmenthic.
SGTC_845 0330-0138 4.51 µM -0.0590861047112474 0.498241641873495 no 1688 0.47644176306957 2505 9039800
SGTC_2089 5281248 129.67 µM -0.0604004203122507 0.497716267645213 no 1689 0.475918361954784 2514 2737878
SGTC_2295 7971645 200 µM -0.0608340801360063 0.497542920686841 no 1690 0.475745674274962 2574 2978226 YKL099C UTP11
SGTC_2402 5553605 200 µM -0.0613824843876327 0.49732370757577 no 1691 0.475527300743481 2563 6758546
SGTC_2874 9043904 71.43 µM -0.0618034452362473 0.497155437839984 no 1692 0.475359679916559 2584 4463428
SGTC_2701 st077767 14.721 µM -0.0625295640656194 0.496865189195377 no 1693 0.475070559639243 2541 5721188
SGTC_2927 9011802 47.9 µM -0.0633062381037956 0.496554734155195 no 1694 0.474761324220529 2577 43912568
SGTC_3259 9138485 49.47 µM -0.0639673323141715 0.496290480750902 no 1695 0.474498119276078 2521 17646153
SGTC_831 k061-1017 217 µM -0.0647981199026733 0.495958399619378 no 1696 0.474167369203271 2585 1240153
SGTC_704 1310-0270 142 µM -0.0651410679070013 0.495821317776372 no 1697 0.474030841194963 2583 5718033
SGTC_2286 7945697 125 µM -0.065370756415923 0.495729507853445 no 1698 0.473939403630886 2556 1245733
SGTC_923 1900-2434 73.3 µM -0.0658547392249377 0.495536053452168 no 1699 0.473746737590721 2511 5910570
SGTC_2473 5854593 8.94 µM -0.0660758860098743 0.495447658471416 no 1700 0.473658704531244 2508 2872951
SGTC_2663 amphotericin b 100 µM -0.0679028968081088 0.494717389638971 no 1701 0.472931466379209 2531 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.067986244447444 0.494684075415619 no 1702 0.472898292144201 2603 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_226 1,3-diallylurea 8.28947 mM -0.069254917739899 0.494176988796917 no 1703 0.472393354982234 2616 74537 YKL182W FAS1
SGTC_1835 st008666 49.2 µM -0.0694730541067009 0.494089800976741 no 1704 0.472306540262753 2549 690455
SGTC_969 1313-0238 134 µM -0.0701036109514781 0.493837772724581 no 1705 0.472055596326103 2540 5212874
SGTC_1477 0139-0234 16 µM -0.0704650143962672 0.493693323918548 no 1706 0.471911772887138 2523 620880
SGTC_2019 4016004 108 µM -0.0709241588196167 0.493509810361097 no 1707 0.471729057915945 2582 45595336
SGTC_1789 tunicamycin 25 nM -0.0713412368048454 0.493343111355847 no 1708 0.471563088297783 2613 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1703 st026983 48.3 µM -0.0717052263810544 0.493197631837303 no 1709 0.471418248410684 2542 1104023
SGTC_210 3551-0445 56.827 µM -0.0727321672762092 0.492787188576067 no 1710 0.471009625271862 2640 2865180 YOR207C RET1
SGTC_1148 3909-7663 27.7 µM -0.0729065995160895 0.492717473005404 no 1711 0.470940221133916 2674 4084526
SGTC_2124 5246320 200 µM -0.0743132969236322 0.49215526465187 no 1712 0.470380548436265 2618 579342
SGTC_3338 9144300 39.5675 µM -0.0745182902292581 0.49207333718432 no 1713 0.470298994064746 2577 4901274
SGTC_1452 4194-0072 190 µM -0.0747423237974365 0.491983800482552 no 1714 0.470209866155375 2616 1343545
SGTC_2512 diallyl trisulfide 49.23 µM -0.0752194644897879 0.491793108965308 no 1715 0.470020048901038 2511 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_929 2805-0021 398 µM -0.0752515672188056 0.491780279025831 no 1716 0.470007277960519 2631 3098024
SGTC_2721 ifenprodil 61.44 µM -0.0753219278480105 0.491752159246411 no 1717 0.469979287569262 2564 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1235 benzylparaben 21.5 µM -0.0782888603046111 0.490566457248228 no 1718 0.468799139227339 2598 7180
SGTC_1999 st074831 12.5 µM -0.0783736259790387 0.490532582751573 no 1719 0.468765426202621 2571 17112523
SGTC_700 3453-2283 142 µM -0.0787799751048561 0.490370196367556 no 1720 0.468603816043646 2626 565664
SGTC_794 k038-0031 316 µM -0.0798776088865522 0.489931564914137 no 1721 0.468167299217428 2535 6624242
SGTC_1125 tnp00248 1.32998 µM -0.0804135117821217 0.489717414210705 no 1722 0.46795419042899 2630 24207736
SGTC_2263 7948595 193.29 µM -0.0806012630600987 0.489642388129451 no 1723 0.467879530849358 2545 2971371
SGTC_1923 st058458 19.1 µM -0.0814097349535636 0.489319324093487 no 1724 0.467558053718371 2579 3534982
SGTC_3272 9137413 49.47 µM -0.0818706753748138 0.489135136183845 no 1725 0.467374776897357 2550 17614870
SGTC_3141 9094609 49.47 µM -0.0824413211994494 0.488907114133295 no 1726 0.467147889149031 2551 25236309 YDL196W YDL196W
SGTC_2 0422-0095 29 µM -0.0825723133705202 0.488854772011927 no 1727 0.467095808402233 2481 6790840
SGTC_736 0958-0254 92.6 µM -0.0828317124257824 0.488751121370738 no 1728 0.46699267644748 2627 6812352
SGTC_493 zm226600 134 µM -0.0846027073052114 0.488043488127139 no 1729 0.466288623334528 2700 5240098 A potassium channel opener. YCR052W RSC6
SGTC_695 3505-6186 243 µM -0.0846440098770706 0.488026985373163 no 1730 0.466272204884881 2633 1819379
SGTC_778 3456-2434 196 µM -0.0850986792393974 0.487845320162764 no 1731 0.466091470157027 2725 5539063
SGTC_2166 5933061 31.504 µM -0.0851780728999416 0.487813598322385 no 1732 0.4660599112546 2900 2877375
SGTC_1959 st077091 55.8 µM -0.0859984777470631 0.487485809049262 no 1733 0.465733813663117 2542 821356 YKL052C ASK1
SGTC_3089 9117425 49.47 µM -0.0860816114014454 0.48745259381867 no 1734 0.465700770666926 2617 9401657
SGTC_2383 9036125 200 µM -0.0870047171285793 0.487083781942708 no 1735 0.465333881301085 2565 79580
SGTC_165 k038-0023 64.381 µM -0.0871729450923111 0.487016570377295 no 1736 0.465267022080737 2578 46368543
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.0876637778016144 0.486820471712828 no 1737 0.465071954936764 2569 688664
SGTC_1180 1193-0155 285 µM -0.0901087096368053 0.48584371507367 no 1738 0.46410041404453 2651 2921347
SGTC_369 0957-0393 4.5 µM -0.0910602031501602 0.485463613569332 no 1739 0.463722377251499 2600 6997992
SGTC_2786 7743617 45.45 µM -0.0911176788976265 0.485440653645178 no 1740 0.463699542673987 2610 583674
SGTC_2062 5245942 200 µM -0.0917707718275112 0.485179765029021 no 1741 0.463440083372133 2549 1376160
SGTC_2833 9001315 45.46 µM -0.0921480069847413 0.485029075179728 no 1742 0.463290223308659 2632 2989378
SGTC_2622 2-methoxyxanthone 59.94 µM -0.0921770483332584 0.485017474450007 no 1743 0.463278686587107 2643 71034 A hepatoprotective.
SGTC_1679 SEC14.276 6.7 µM -0.0921956344462414 0.485010050129476 no 1744 0.463271303240586 2700 1005053 YMR079W SEC14
SGTC_942 3253-1115 227 µM -0.093681631832468 0.484416477697493 no 1745 0.462681030886689 2670 46497897
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.093843369859715 0.484351874506643 no 1746 0.462616789755842 2637 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_430 0958-0115 16.4 µM -0.0950679152649672 0.483862766491999 no 1747 0.462130441264641 2606 6833180
SGTC_1661 st013063 9.66 µM -0.0961407461324072 0.48343427623924 no 1748 0.461704395218659 2576 721395
SGTC_3198 9112019 49.47 µM -0.096358117613555 0.48334746005949 no 1749 0.461618077294463 2584 45595555
SGTC_2983 9022671 12.99 µM -0.0968116053672223 0.483166343748397 no 1750 0.461438003739569 2786 6405161
SGTC_67 0335-0847 266 µM -0.0993378930522791 0.482157446374424 no 1751 0.460434996444473 2938 4552207 YOR254C SEC63
SGTC_1034 k072-0165 12.7 µM -0.100227818225163 0.481802073046427 no 1752 0.46008173072902 2597 5835461
SGTC_3199 9111318 49.47 µM -0.100783945968295 0.481580002185271 no 1753 0.459860985603108 2664 8548020
SGTC_610 4215-0184 155 µM -0.100861867507897 0.481548887300951 no 1754 0.45983005700518 2633 5605015
SGTC_2844 9010103 25.97 µM -0.101187413176531 0.481418894734422 no 1755 0.459700844131447 2748 2480525
SGTC_2064 5220758 200 µM -0.101730076095937 0.481202210193347 no 1756 0.459485464355675 2711 788518
SGTC_2722 naftopidil 47.16 µM -0.101805229759787 0.481172201877363 no 1757 0.459455637236838 2582 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_532 1548-0774 215 µM -0.101987654611316 0.48109936139387 no 1758 0.459383237089189 2785 5932993
SGTC_3193 9111931 49.47 µM -0.104429214407846 0.480124531824488 no 1759 0.458414369839287 2603 17087244
SGTC_1242 0402-0103 60.1 µM -0.105197305058845 0.479817884350623 no 1760 0.458109624555028 2595 432868
SGTC_3114 9122766 49.47 µM -0.106105214809276 0.479455431833934 no 1761 0.457749436842829 2652 17176985
SGTC_2945 9067681 61.76 µM -0.106106351646386 0.479454978000433 no 1762 0.4577489858563 2554 16456930
SGTC_11 0438-0307 1.3 µM -0.106932097588131 0.479125341391255 no 1763 0.457421424489937 2690 4011476
SGTC_873 0591-4978 488 µM -0.107249925673011 0.478998468663307 no 1764 0.457295354422487 2766 3305145
SGTC_2135 5326629 150.42 µM -0.107908915227128 0.478735415626716 no 1765 0.457033972545994 2627 5020077
SGTC_1129 3453-1384 223 µM -0.108231155126581 0.478606788448852 no 1766 0.456906165944719 2820 1084452
SGTC_1457 k015-0032 57.3 µM -0.109739506017519 0.478004736058208 no 1767 0.456307984169449 2589 4302660
SGTC_947 3447-0010 211 µM -0.11045399183365 0.477719569258272 no 1768 0.45602466786858 2565 748350
SGTC_1956 st077085 54 µM -0.110689579012377 0.477625543794564 no 1769 0.455931254970079 2639 24208685
SGTC_2606 farnesol 9.78 µM -0.111893656130259 0.477145002784026 no 1770 0.455453863345332 2682 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2340 7987427 183.45 µM -0.112261187355071 0.476998329542289 no 1771 0.455308157611295 2686 2239331
SGTC_2929 9013348 24.6 µM -0.112329848252435 0.476970928905341 no 1772 0.455280938041767 2684 2995952
SGTC_1337 1486-1011 40.3 µM -0.112864309710109 0.476757644071285 no 1773 0.455069066104492 2610 X1337
SGTC_2355 9061122 103.12 µM -0.112978358338147 0.476712132121321 no 1774 0.455023856444909 2701 5302957
SGTC_1911 st060208 74.3 µM -0.115460547807963 0.475721672290602 no 1775 0.454040044789031 2712 688783
SGTC_1026 k007-1105 30.6 µM -0.116674358782766 0.475237383553979 no 1776 0.453559055099483 2610 7066794
SGTC_213 1246-0773 967 nM -0.117342168070414 0.474970955219588 no 1777 0.453294455267458 2645 6251622
SGTC_2888 9058547 12.99 µM -0.117691489848497 0.474831594703179 no 1778 0.45315605501644 2639 16476514
SGTC_1315 1237-0019 3.69 µM -0.118280603187326 0.47459657729382 no 1779 0.452922662958885 2670 825140
SGTC_85 0868-0259 160.055 µM -0.11938171511815 0.474157329943559 no 1780 0.452486473455711 2686 83173
SGTC_934 2950-0684 338 µM -0.119583042442854 0.474077021331611 no 1781 0.452406726743841 2828 1121253
SGTC_1367 1812-0510 76.9 µM -0.120128983040853 0.47385925326416 no 1782 0.452190486744783 2666 1142582 YDR527W RBA50
SGTC_1175 0741-0056 27.6 µM -0.120442216750982 0.473734312241318 no 1783 0.452066425327998 2755 765927
SGTC_2971 9092186 9.93 µM -0.120490105457379 0.473715210872144 no 1784 0.452047458622103 2624 25236400
SGTC_2848 9016370 25.97 µM -0.121594355615398 0.473274775444064 no 1785 0.45161014194268 2624 7894410
SGTC_2350 9023895 38.85 µM -0.122059377014836 0.473089309191495 no 1786 0.451425996850733 2737 2997209
SGTC_2560 caryophyllene 100 µM -0.122083435805245 0.473079713891024 no 1787 0.45141647002874 2609 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_3185 9108267 49.47 µM -0.122384332535611 0.472959709406003 no 1788 0.451297323029411 2670 4910486
SGTC_2950 9072895 21.46 µM -0.122402001203808 0.472952662813961 no 1789 0.451290326849061 2694 17332245
SGTC_3170 9103054 49.47 µM -0.122640217960227 0.472857658387788 no 1790 0.451196002746283 2685 16432970
SGTC_479 n-linoleoylglycine 10 µM -0.123120831668963 0.472665987115994 no 1791 0.4510057077476 2631 6433346 An anti-infammatory.
SGTC_1468 k284-1086 134 µM -0.124312307292309 0.472190847766384 no 1792 0.45053400153951 2638 15996457
SGTC_2216 7189485 200 µM -0.126595597436657 0.471280423300591 no 1793 0.449630240821008 2687 731273
SGTC_2199 6590217 200 µM -0.127272055443712 0.471010725375686 no 1794 0.449362538472943 2660 703109
SGTC_2442 5158906 48.48 µM -0.127757375804332 0.47081724055185 no 1795 0.449170491370718 2755 1893835
SGTC_1863 st057641 20.1 µM -0.12958699956838 0.470087878634102 no 1796 0.44844659467628 2632 3921635
SGTC_1841 st054148 70 µM -0.130114090728299 0.469877777322599 no 1797 0.448238081051466 2700 675442
SGTC_1190 1486-1332 13 µM -0.130179000165298 0.46985190465803 no 1798 0.448212404313964 2611 4150046
SGTC_463 ikarugamyin 104 µM -0.13022216210502 0.469834700536917 no 1799 0.448195330525434 2637 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2293 7624732 200 µM -0.130321620443272 0.469795057183252 no 1800 0.448155987648944 2624 894453
SGTC_3253 9135987 49.47 µM -0.1307029993174 0.469643045180122 no 1801 0.448005129794731 2760 4182430
SGTC_1706 st031321 9.9705 µM -0.131314413156701 0.469399353868902 no 1802 0.447763295234839 2727 6103185
SGTC_335 4077-0256 27.6 µM -0.13199131501605 0.469129574360678 no 1803 0.44749558062938 2739 3121989
SGTC_1717 st033143 58.0435 µM -0.132082115921815 0.46909338669856 no 1804 0.447459670698613 2730 674616
SGTC_1947 st076332 61.6 µM -0.132817287984133 0.468800401712649 no 1805 0.44716894082895 2716 24208416
SGTC_2139 5578692 56.4705 µM -0.132989697108938 0.468731694679483 no 1806 0.447100764318679 2647 650991 YMR113W FOL3
SGTC_1265 0819-1001 68.8 µM -0.134179659599544 0.468257506348127 no 1807 0.446630254870104 2611 3106768
SGTC_1725 st036284 20.55 µM -0.1355350502529 0.46771745141845 no 1808 0.44609442691226 2886 707914
SGTC_311 1315-0136 58 µM -0.13590637102881 0.467569509111725 no 1809 0.445947649429145 2785 6759207
SGTC_2188 6126565 140.678 µM -0.136048716093966 0.467512796915587 no 1810 0.445891384542028 2689 874518
SGTC_2803 7707263 71.43 µM -0.136827632383895 0.467202477854475 no 1811 0.445583520785548 2677 2199229
SGTC_1691 st019933 84.6 µM -0.136886506331521 0.467179023371492 no 1812 0.445560252408851 2630 6176082
SGTC_2281 7943571 200 µM -0.138257563164634 0.466632847634739 no 1813 0.445018431516424 2722 1244024
SGTC_359 0081-0058 15.9 µM -0.139880187988902 0.465986538247754 no 1814 0.444377327534505 2989 3494159
SGTC_1810 st050138 53 µM -0.139899586765842 0.46597881203985 no 1815 0.444369663895812 2645 3444541
SGTC_280 3448-3607 3.04 µM -0.140685512880648 0.465665801648733 no 1816 0.444059195153231 2659 626179
SGTC_2130 NSC 7 2.4545 µM -0.140867513411872 0.465593319412132 no 1817 0.443987303364226 2744 21448
SGTC_1875 nocodazole 6 µM -0.14167513863623 0.465271694140031 no 1818 0.443668306661624 2643 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1308 1187-1617 41.4 µM -0.14194426499328 0.465164523420469 no 1819 0.443562014933478 2631 2882570
SGTC_1922 5578187 25 µM -0.143815156571972 0.464419572646959 no 1820 0.442823217042008 2893 1350412
SGTC_334 1502-1024 68.5 µM -0.146136828648881 0.463495303980542 no 1821 0.44190668671608 2760 3296216
SGTC_3126 9127922 49.47 µM -0.146217923411238 0.463463023302853 no 1822 0.441874678394115 2922 45595682
SGTC_2638 epoxomicin 18 µM -0.146892698572423 0.4631944308472 no 1823 0.441608357550887 2775 9915668 A protesome inhibitor.
SGTC_1626 st003712 1.76 µM -0.147518528262664 0.462945335999358 no 1824 0.441361378139539 2809 24207035
SGTC_2373 9071805 200 µM -0.147552300178034 0.462931894399792 no 1825 0.441348050931425 2671 10149009
SGTC_3147 9097027 49.47 µM -0.147594722485763 0.462915009907414 no 1826 0.44133131016504 2708 25236841
SGTC_1270 0831-1170 17.3 µM -0.147635404639716 0.462898818075975 no 1827 0.441315256199685 2667 6764716
SGTC_1945 st075991 56.6 µM -0.148480285868464 0.462562562341357 no 1828 0.4409818715476 2722 1084980
SGTC_3320 9137005 35.139 µM -0.150563038754729 0.461733758689508 no 1829 0.440160209869107 2735 4908713
SGTC_3309 9129340 25.759 µM -0.151391110246245 0.461404284675991 no 1830 0.43983360081795 2728 17158987
SGTC_1499 4480-0877 67.3 µM -0.151491852739655 0.461364202942526 no 1831 0.439793868619773 2676 2861909
SGTC_2450 5739737 12.93 µM -0.152339446828707 0.461026992004084 no 1832 0.439459606956963 2760 2262825
SGTC_841 0251-0215 91.2 µM -0.152891632514492 0.460807322834569 no 1833 0.439241867307641 2722 3888614
SGTC_3258 9138477 49.47 µM -0.152985086967773 0.460770146192223 no 1834 0.439205017861721 2686 4970355
SGTC_2457 5731572 11.68 µM -0.153025884644565 0.460753916782714 no 1835 0.43918893134797 2832 2865357
SGTC_997 3996-0078 137 µM -0.153153442313191 0.460703174471074 no 1836 0.439138636039142 2742 735687
SGTC_1634 st006576 41 µM -0.153371885041326 0.46061627966123 no 1837 0.439052507518292 2773 3915356
SGTC_1043 0916-0009 19.3 µM -0.153788795319912 0.460450441234404 no 1838 0.438888134386283 2673 3101130
SGTC_506 n9-isopropylolomoucine 153 µM -0.154034572525128 0.460352679283667 no 1839 0.438791237971718 2671 6610355
SGTC_1898 st060199 18.6 µM -0.154456636310706 0.460184802023014 no 1840 0.43862485003009 2674 688866
SGTC_854 0422-0053 192 µM -0.156295754408938 0.459453369972232 no 1841 0.437899951352899 2691 3596728
SGTC_1167 k781-0610 148 µM -0.157838815832407 0.45883978779916 no 1842 0.437291905701675 2747 4525169
SGTC_1222 0366-0074 1.18 µM -0.15952245341129 0.458170418894357 no 1843 0.436628634779827 2810 286520
SGTC_24 0417-1663 219 µM -0.160891364738282 0.457626263997064 no 1844 0.436089481820088 2757 4329390
SGTC_746 1095-0025 46.6 µM -0.161024899338544 0.457573186995247 no 1845 0.43603689485231 2830 6749286
SGTC_684 1140-0066 328 µM -0.16234592505699 0.45704814988795 no 1846 0.435516725683668 2752 6813534
SGTC_252 miconazole 1.30953 nM -0.163047036659522 0.456769525896728 no 1847 0.435240700128249 2760 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2050 5263056 171 µM -0.163193567062186 0.456711296926814 no 1848 0.435183015525769 2804 763468 YGL055W OLE1
SGTC_1319 1306-0155 43.7 µM -0.163863015080875 0.456445280233128 no 1849 0.434919491585765 2693 3122360
SGTC_569 4130-2812 160 µM -0.164749502567013 0.456093049228359 no 1850 0.434570575946746 2673 743552
SGTC_3264 9137442 49.47 µM -0.16517206540261 0.455925163065284 no 1851 0.434404275913108 2923 17015726
SGTC_2316 5844804 197.44 µM -0.165806488362395 0.455673118683495 no 1852 0.434154619915404 2814 776813
SGTC_764 1951-2361 146 µM -0.166820745358062 0.455270210437437 no 1853 0.433755547491092 2727 5438930
SGTC_2656 pseudo-anisatin 100 µM -0.166964550020094 0.455213088507509 no 1854 0.433698971158083 2702 6708809 A neurotoxin.
SGTC_1010 4112-3296 15.2 µM -0.167229204880982 0.455107965015339 no 1855 0.433594852900416 2856 704384
SGTC_500 h-89 112 µM -0.167459315568849 0.455016565360213 no 1856 0.433504328461394 2885 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_124 0136-0217 7.121 µM -0.168420782004015 0.454634698003579 no 1857 0.433126129974667 2763 3976905
SGTC_1778 st046819 58.9 µM -0.16958116468664 0.454173882583359 no 1858 0.432669768192769 2712 671715
SGTC_1267 0828-0272 9.49 µM -0.169690251154545 0.45413056492786 no 1859 0.43262687066567 2832 745334
SGTC_2635 hydroquinidine 100 µM -0.170136776172518 0.453953257913981 no 1860 0.432451285958622 2711 442912 An experimental heart treatment.
SGTC_2696 st077691 74.316 µM -0.170232390197308 0.453915292504597 no 1861 0.432413689886414 2852 757133
SGTC_1017 4239-0030 168 µM -0.171191101878275 0.453534640710112 no 1862 0.432036751944467 2738 1149593
SGTC_3011 9081274 71.4286 µM -0.1723173257304 0.453087533573339 no 1863 0.431594032061177 2743 6625322
SGTC_3154 9100113 49.47 µM -0.172541129296788 0.452998691363825 no 1864 0.43150606483838 2725 25237525
SGTC_2591 skatole 100 µM -0.17405898930157 0.452396216194257 no 1865 0.430909551472391 2848 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_867 0518-0118 155 µM -0.174574149224281 0.452191761661468 no 1866 0.430707131278443 2741 6848158
SGTC_1556 plumbagin 1.48 µM -0.175055548069722 0.45200071754219 no 1867 0.430517993172253 2705 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_378 3970-0959 8.33 µM -0.176545360048233 0.451409553215623 no 1868 0.429932758053195 2844 6615653
SGTC_1796 st049173 110.4 µM -0.176589643817244 0.451391982852437 no 1869 0.429915364638874 2692 94134
SGTC_2511 berberine 10.47 µM -0.177758570297499 0.450928225276452 no 1870 0.429456292598755 2735 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1693 xanthone 101.9 µM -0.177781900980082 0.450918969787334 no 1871 0.429447130917712 2757 7020 An insecticide.
SGTC_1642 st009582 77.7 µM -0.178164990527891 0.450766998579558 no 1872 0.429296701655478 2824 6739311
SGTC_2894 9048625 32.47 µM -0.178355952407782 0.450691246903196 no 1873 0.42922171974477 2845 4092861
SGTC_1853 st056710 91.2 µM -0.179437390494152 0.450262290811635 no 1874 0.428797137213873 2897 269167
SGTC_372 0155-0182 15.9 µM -0.179532618477146 0.450224521084557 no 1875 0.428759753772191 2726 771486
SGTC_129 0088-0017 176.636 µM -0.180458913710616 0.449857153506624 no 1876 0.42839615346587 2769 182446
SGTC_37 0566-0070 1.56 µM -0.181815093398846 0.449319371861983 no 1877 0.427863919563507 2836 1626686
SGTC_1830 st055982 50.3 µM -0.184579986173328 0.448223266266215 no 1878 0.426779242457754 2715 455313 An antimicrobial agent.
SGTC_1791 st048313 56.1 µM -0.185845911037536 0.447721538284733 no 1879 0.426282799922993 2871 1204976
SGTC_2179 6298986 200 µM -0.186852171177257 0.447322783659955 no 1880 0.425888270252066 2850 738374
SGTC_2865 9030313 51.95 µM -0.186923734367678 0.447294427058836 no 1881 0.425860214918618 2723 42562754
SGTC_2283 7944793 200 µM -0.186998516668331 0.447264795187239 no 1882 0.425830897979671 2807 2970533
SGTC_2173 5763948 167 µM -0.187932687150201 0.446894662675188 no 1883 0.425464709304647 2724 2867177
SGTC_1546 5-methoxyflavanone 78.7 µM -0.188842914324529 0.446534061351806 no 1884 0.42510796807849 2825 147795
SGTC_3240 9133527 49.47 µM -0.188998823687884 0.446472299743967 no 1885 0.42504686936851 2771 17617455
SGTC_3060 1327-0027 12.5 µM -0.191417730425309 0.445514246373869 no 1886 0.424099165012213 2837 16000455 YPR107C YTH1
SGTC_2113 5491891 107.031 µM -0.19170843538547 0.445399128524688 no 1887 0.423985299034092 2765 789979
SGTC_2857 9024691 58.44 µM -0.192251288649626 0.445184173420164 no 1888 0.423772686297481 2860 16478292
SGTC_342 k048-0088 23.3 µM -0.193052484905678 0.444866950991261 no 1889 0.423458932059722 2711 6820570
SGTC_2816 7982706 58.44 µM -0.195623040429851 0.443849414900565 no 1890 0.422452612523497 2858 2981853
SGTC_2182 6325192 200 µM -0.195702906563404 0.443817806353465 no 1891 0.422421354647715 2731 736248
SGTC_3301 9125354 19.7965 µM -0.197327259592682 0.443175015463952 no 1892 0.421785724317965 2734 41905162
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.198081411567113 0.442876632278073 no 1893 0.421490684050423 2765 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1014 4130-3005 69.3 µM -0.199515471142313 0.442309330489558 no 1894 0.420929771204038 2750 743608
SGTC_1652 st011932 78 µM -0.200465756745426 0.441933470664122 no 1895 0.420558168277613 2849 1551076
SGTC_2900 5328528 85.29 µM -0.200744329097302 0.441823298780858 no 1896 0.420449247796056 2755 795359
SGTC_200 k038-0079 37.545 µM -0.201121921531255 0.44167397287864 no 1897 0.42030162065208 2795 3436683
SGTC_254 nsc-64875 3.808 µM -0.202093066499934 0.441289953790118 no 1898 0.419921984084583 2912 56993
SGTC_2352 9027995 87.8 µM -0.203943019336264 0.440558581393666 no 1899 0.419199013460261 2821 2997347
SGTC_3052 9092717 49.47 µM -0.203969218856993 0.440548224954626 no 1900 0.41918877651219 2942 25237534
SGTC_1304 1165-0502 251 µM -0.205204084212774 0.440060139842281 no 1901 0.418706339302775 2810 767425
SGTC_2314 7727897 200 µM -0.205528873102505 0.439931780925956 no 1902 0.41857947104997 2781 900724
SGTC_247 mechlorethamine 29.705 µM -0.205775592040254 0.439834280037602 no 1903 0.418483103952687 2760 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1487 3970-0795 2.82 µM -0.205959091465361 0.43976176524236 no 1904 0.418411433231052 2848 3765103
SGTC_492 tmb-8 126 µM -0.207293267407602 0.439234590196849 no 1905 0.417890415895249 2854 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2728 chlorpromazine 9.18 µM -0.208767154948308 0.438652335992053 no 1906 0.417315006447551 2741 2726 A thorazine and dopamine antagonist.
SGTC_2117 5521686 200 µM -0.209096170432027 0.43852237763586 no 1907 0.417186582092381 2756 803312
SGTC_559 1550-0661 158 µM -0.211396873403341 0.437613805263388 no 1908 0.416288798140793 2859 5830875
SGTC_545 4218-0007 221 µM -0.212814842566086 0.437053997458748 no 1909 0.415735693117437 2904 2840508
SGTC_3182 9108849 49.47 µM -0.212875863304471 0.437029909567616 no 1910 0.41571189459076 2871 17133045
SGTC_3268 9137683 49.47 µM -0.213625880877263 0.436733859783148 no 1911 0.415419407622172 2759 1953228
SGTC_2239 6685329 187.64 µM -0.214094256720901 0.436548998652416 no 1912 0.415236777219716 2914 805680
SGTC_637 1181-0519 7.26 µM -0.214357676821743 0.436445036656846 no 1913 0.415134071769891 2791 6252091 YGR060W ERG25
SGTC_183 3914-0051 30.55 µM -0.215653413442128 0.435933722240473 no 1914 0.414628958682768 2907 1596232
SGTC_2329 6138490 200 µM -0.216689665387208 0.435524880836419 no 1915 0.414225101244382 3050 720019
SGTC_3227 9130768 49.47 µM -0.218643390789489 0.434754248487691 no 1916 0.413463924755361 2792 17720899
SGTC_1878 temozolomide 1 mM -0.218675571340796 0.434741557176822 no 1917 0.413451389842803 2821 5394 DNA alkylating agent.
SGTC_164 4100-3994 89.624 µM -0.219519689239867 0.434408679454676 no 1918 0.413122622042177 2836 4615967
SGTC_2626 ethyl orsellinate 100 µM -0.220361381147128 0.434076804718896 no 1919 0.412794859771654 2776 75653 A natural product.
SGTC_1205 4161-2785 76 µM -0.220478132283152 0.434030774017963 no 1920 0.412749400642652 2928 3498106
SGTC_2034 5197015 53.07 µM -0.221106368045329 0.4337830990171 no 1921 0.412504805991377 2938 780676
SGTC_1071 trifluoperazine 6.31 µM -0.221410833927901 0.433663076056778 no 1922 0.412386278750421 2956 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2163 5671233 125 µM -0.222411923868244 0.433268481329731 no 1923 0.411996615181585 2973 701023
SGTC_1341 1486-1360 280 µM -0.222737636539528 0.433140111080901 no 1924 0.411869853688638 2780 3976547
SGTC_3051 9093778 49.47 µM -0.224243405246635 0.432546747701227 no 1925 0.411283955411384 2780 17217378
SGTC_1782 st039423 80.636 µM -0.224567673893898 0.432418986219538 no 1926 0.41115780753133 2851 2068169
SGTC_2070 5230947 200 µM -0.224862253204212 0.43230292842789 no 1927 0.411043217441112 2894 2835538
SGTC_2133 5320837 200 µM -0.2269132825921 0.431495030258082 no 1928 0.410245586711781 2957 2841355
SGTC_568 1193-0097 7.48 µM -0.227092413831237 0.431424484218902 no 1929 0.410175941424455 2901 3646150
SGTC_2987 9018338 71.43 µM -0.227398022260206 0.431304133577474 no 1930 0.410057129009179 2765 5055682
SGTC_3120 9124077 49.47 µM -0.228129121220409 0.431016247819809 no 1931 0.409772930732911 2777 18774327 YGL155W CDC43
SGTC_484 loperamide 105 µM -0.229432027013195 0.430503291914839 no 1932 0.40926657300154 2773 3955 An opioid-receptor agonist.
SGTC_1153 4055-0057 267 µM -0.229772401655736 0.430369305203581 no 1933 0.409134315634498 2814 882706
SGTC_1143 3454-2408 5.08 µM -0.233130383973824 0.429047884947949 no 1934 0.407830080922013 2797 X1143
SGTC_894 0960-0238 55.9 µM -0.233834424827435 0.428770933801121 no 1935 0.407556761592754 2800 6741907 YDL195W SEC31
SGTC_57 miconazole 162.5 nM -0.234160322935872 0.428642745925868 no 1936 0.407430258234051 2772 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1843 st055809 45.5 µM -0.23440919042479 0.42854486213306 no 1937 0.407333662230183 2959 16413835
SGTC_440 fluspirilene 35.1 µM -0.23446313358504 0.428523645955137 no 1938 0.407312725349833 3054 3396 An atypical antipsychotic.
SGTC_773 4358-1457 44.6 µM -0.234479746867317 0.428517111890265 no 1939 0.407306277314072 2989 1186886
SGTC_2072 5231554 129 µM -0.234481816588834 0.428516297862571 no 1940 0.407305474004474 2924 789545
SGTC_191 3914-0123 66.505 µM -0.23461797342245 0.428462747638908 no 1941 0.407252629060032 2818 3144412
SGTC_93 0109-0045 59.227 µM -0.235000015864613 0.428312498109046 no 1942 0.407104360453673 2767 88733
SGTC_2904 7225135 42.03 µM -0.2353619707112 0.428170158208034 no 1943 0.406963900013756 2912 4446116
SGTC_2620 irigenin 100 µM -0.23543428273212 0.428141722393972 no 1944 0.406935839996003 3008 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2533 agelasine 13.65 µM -0.235583226973139 0.428083153076567 no 1945 0.406878045052241 2991 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_420 mitomycin C 81.9 mM -0.236435064682447 0.427748215565192 no 1946 0.406547544838359 2835 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_220 paclitaxel 373.376 µM -0.236477758515067 0.427731429972587 no 1947 0.406530982023331 2932 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_787 4152-0075 138 µM -0.237894931294068 0.427174325899218 no 1948 0.405981293458586 2851 9566539
SGTC_3031 9088762 49.47 µM -0.238152349269278 0.427073148000453 no 1949 0.405881466830321 2786 205253
SGTC_1672 st016598 6.51 µM -0.238263680165453 0.427029390979625 no 1950 0.405838294631141 2880 4665860 YNL267W PIK1
SGTC_2675 theaflavin digallate 100 µM -0.239448913921816 0.426563607521354 no 1951 0.40537875253839 2847 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1781 st038725 66.3 µM -0.241118819205743 0.425907527547335 no 1952 0.404731513698174 2834 4270275 YIL048W NEO1
SGTC_930 2810-3379 265 µM -0.241362414828177 0.425811839686578 no 1953 0.404637120170107 3032 1015764
SGTC_1277 0873-0036 22 µM -0.242004543796252 0.425559623150976 no 1954 0.404388321213563 2921 5965735
SGTC_2970 9090938 41.86 µM -0.242593819012068 0.425328193401045 no 1955 0.404160034959787 3076 17217104
SGTC_456 gingerol 170 µM -0.243837780640972 0.424839729124185 no 1956 0.403678229283571 3015 442793 A herb.
SGTC_2367 9070478 135.38 µM -0.244294004606204 0.424660613321583 no 1957 0.403501563234963 2815 572802
SGTC_2196 6573537 42.6665 µM -0.244662761848217 0.424515848756522 no 1958 0.403358781780844 2935 2903087
SGTC_936 3005-4620 401 µM -0.245539375462643 0.424171753807538 no 1959 0.40301941194002 3052 777207
SGTC_299 1273-0059 1.44 µM -0.245940884613897 0.424014169706808 no 1960 0.402863997138617 2945 2848077
SGTC_1482 3346-2049 8.48 µM -0.247139243509812 0.423543910773984 no 1961 0.402400231784473 2937 3826804
SGTC_2004 4023728 41.89 µM -0.247774506469632 0.423294665561948 no 1962 0.402154440430455 2991 360084 YDR527W RBA50
SGTC_2581 avocatin a 64 µM -0.250204842355829 0.42234140824858 no 1963 0.401214470337719 2897 6710728 A skin care supplement.
SGTC_759 3486-0358 89.3 µM -0.250443217388412 0.422247934151757 no 1964 0.40112230578414 3017 875103
SGTC_486 niguldipine 82 µM -0.251229578047395 0.421939609310506 no 1965 0.400818308874926 2827 1236 A calcium channel blocker.
SGTC_1029 k015-0030 64.7 µM -0.251759912493187 0.421731697011884 no 1966 0.400613322299822 2965 2208316
SGTC_1757 st041620 31.8375 µM -0.252017527523175 0.421630709492861 no 1967 0.400513757982625 2920 5289815
SGTC_1232 0279-0259 161 µM -0.255042218689342 0.420445389300042 no 1968 0.399345245679112 2871 1560000
SGTC_2040 5100729 123 µM -0.255482964774 0.420272729043578 no 1969 0.399175049647178 2858 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1794 st048918 76.9 µM -0.255809304356903 0.420144896891899 no 1970 0.399049044533088 2897 672303
SGTC_1209 2323-2347 50.3 µM -0.25650087512791 0.419874026014049 no 1971 0.398782052392162 2874 5412760
SGTC_781 4335-2806 94.4 µM -0.256823268806752 0.419747765481155 no 1972 0.398657603247353 3033 845254
SGTC_406 estrone 100 µM -0.257032596335946 0.419665789991506 no 1973 0.398576804970885 3046 5870 A steroid.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.257645530532273 0.419425776736454 no 1974 0.398340243678534 2804 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1806 st050005 60.3 µM -0.258449726632863 0.419110914472521 no 1975 0.398029921731317 2867 5194765
SGTC_1402 3909-7673 35.9 µM -0.259066050861541 0.41886964364867 no 1976 0.397792139133931 2823 5328014
SGTC_3220 9131269 49.47 µM -0.259419886846212 0.418731142187596 no 1977 0.39765564365549 2808 17722206
SGTC_629 3448-6466 76.7 µM -0.25980161527211 0.418581734128069 no 1978 0.397508402461309 2899 573744
SGTC_3136 9095672 49.47 µM -0.260025135169256 0.418494254152248 no 1979 0.397422192613153 2768 17217380
SGTC_881 0833-0569 170 µM -0.260628020191826 0.418258320471816 no 1980 0.397189689644807 2881 5418700
SGTC_2741 miltefosine 3.04 µM -0.260707810241353 0.418227097548868 no 1981 0.397158921300181 2872 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2949 9072542 2.23 µM -0.262186111999385 0.417648711542101 no 1982 0.396588980000588 2969 16457352
SGTC_3222 9128301 49.47 µM -0.263168874546545 0.41726430387933 no 1983 0.396210209975021 2896 4911358
SGTC_248 streptozotocin 5.23457 mM -0.264330366545703 0.416810088145649 no 1984 0.395762681508897 2958 5300 DNA alkylating agent.
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.265098468430014 0.416509773408793 no 1985 0.395466803579453 2943 688761
SGTC_3163 9099914 49.47 µM -0.265116569681891 0.416502696715028 no 1986 0.395459831583349 2962 16268368
SGTC_1790 st045711 43.5 µM -0.266538107942013 0.415947030293881 no 1987 0.394912407305098 3035 585119
SGTC_1889 st059080 5.18 µM -0.266570660930523 0.415934307589067 no 1988 0.394899873805541 3038 176925 Isolated from Daphnopsis sellowiana.
SGTC_108 0509-0257 621.132 µM -0.268624248531722 0.415131881296017 no 1989 0.3941094251547 2970 536624
SGTC_669 0108-0021 26.2 µM -0.270081139831242 0.414562824669957 no 1990 0.393548915680456 3015 17201
SGTC_3029 9088683 49.47 µM -0.271510465312123 0.414004709350519 no 1991 0.392999225877306 3036 25236615
SGTC_362 0310-0100 9.03 µM -0.272065848322233 0.413787893162785 no 1992 0.392785694233157 3014 790235
SGTC_3043 9092303 49.47 µM -0.272805977593388 0.413498994666799 no 1993 0.392501182172817 2920 25236084
SGTC_3347 9188721 44.724 µM -0.272862979625436 0.41347674670799 no 1994 0.392479272481661 2957 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_820 1582-0060 59.9 µM -0.27327234262929 0.413316980020818 no 1995 0.392321936931165 2940 3848840
SGTC_2815 7968870 71.43 µM -0.274373998570266 0.412887095766579 no 1996 0.391898611347915 2886 2977326 YHR190W ERG9
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.274517980938678 0.41283091918651 no 1997 0.391843293698465 2914 2724 A muscle relaxant with antifungal properties.
SGTC_2988 9073640 71.4286 µM -0.275625795409325 0.412398750857532 no 1998 0.391417747483376 3091 9102229
SGTC_3155 9099265 49.47 µM -0.275813122379519 0.412325683413798 no 1999 0.391345802158836 2993 25236499
SGTC_3195 9113082 49.47 µM -0.278025700136726 0.411462891427779 no 2000 0.390496315174822 2965 17018038
SGTC_1705 st027868 56.3335 µM -0.278052225728923 0.411452550393531 no 2001 0.390486134221589 2975 292948
SGTC_2044 5102272 200 µM -0.278302664473221 0.411354919578734 no 2002 0.390390015464901 2982 592666
SGTC_510 ag-490 170 µM -0.279750797603146 0.410790488482722 no 2003 0.389834351385915 2973 5328779
SGTC_821 1114-0266 29.2 µM -0.283789492573239 0.40921732717895 no 2004 0.388285853668483 2970 3123235
SGTC_3121 9125696 49.47 µM -0.283920876282062 0.409166174709665 no 2005 0.388235508799848 2923 1235365
SGTC_1049 3226-0134 66 µM -0.284817414309462 0.408817161091296 no 2006 0.387892014938577 2936 5702385
SGTC_3079 9117512 49.47 µM -0.284878097100388 0.408793540474343 no 2007 0.387868768487181 2905 7185044
SGTC_903 1134-0042 114 µM -0.284922722584007 0.408776170333447 no 2008 0.387851673548735 2916 701009
SGTC_193 1273-0060 1.558 µM -0.285056561503757 0.408724075594141 no 2009 0.387800404414282 2887 2847393 YHR072W ERG7
SGTC_1063 disulfiram 1.84 µM -0.285513382557202 0.408546277181801 no 2010 0.387625426555017 2907 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1202 1988-0068 29.6 µM -0.286576627077548 0.408132526845191 no 2011 0.387218256496816 2907 2850480
SGTC_2227 7312221 64.1025 µM -0.286732662585693 0.408071815887307 no 2012 0.387158513043264 2920 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_634 1611-4317 11.2 µM -0.287266145198676 0.407864262887618 no 2013 0.386954271443282 2928 2843522
SGTC_1344 1488-0097 29.1 µM -0.287377043057894 0.407821120989056 no 2014 0.386911818586522 3007 747966
SGTC_2661 dactinomycin 12.96 µM -0.287600023524569 0.40773437968027 no 2015 0.386826463434512 2944 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_321 4534-3890 65.3 µM -0.288179628812418 0.407508929433377 no 2016 0.386604620747942 3028 699746
SGTC_1233 0325-0408 14.2 µM -0.289375154438617 0.407044000230771 no 2017 0.386147152973677 3013 12874
SGTC_441 propafenone 146 µM -0.289763418935734 0.406893035786353 no 2018 0.385998617608962 2895 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2279 7948423 32.93 µM -0.28977403183433 0.406888909488484 no 2019 0.385994557748436 3126 1247112
SGTC_1497 4476-2978 41.3 µM -0.290481725932889 0.406613781176012 no 2020 0.385723864490364 3000 1528379
SGTC_309 k408-0051 1.48 µM -0.291263021941253 0.406310092383783 no 2021 0.385425083101643 2952 3640463
SGTC_3134 9127454 49.47 µM -0.2916651428347 0.406153810444003 no 2022 0.385271331460867 3004 24262820
SGTC_3243 9134147 49.47 µM -0.29312850011155 0.405585211557115 no 2023 0.384711966571398 2979 24282180
SGTC_2965 9082772 38.63 µM -0.293567282137439 0.405414758135886 no 2024 0.384544289869411 3115 16459634
SGTC_408 cantharidin 100 µM -0.295066072757544 0.404832659199271 no 2025 0.383971703242924 2967 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3069 9117009 49.47 µM -0.29547804193511 0.404672695817223 no 2026 0.383814361963378 2984 41904981
SGTC_985 1493-0307 8.71 µM -0.295857019841504 0.404525556672922 no 2027 0.383669637783117 3074 3278274
SGTC_544 k015-0020 52.4 µM -0.295859488368748 0.404524598305124 no 2028 0.383668695154468 2965 3008304
SGTC_2784 7567673 72.73 µM -0.296853992888712 0.40413854385849 no 2029 0.383288990998115 2885 3471247
SGTC_792 4534-1957 155 µM -0.297542822954891 0.403871203173218 no 2030 0.383026059744691 2963 1717904
SGTC_3045 9092950 49.47 µM -0.298174738767798 0.403625990866639 no 2031 0.38278490044666 3073 44120432
SGTC_1456 k015-0012 13 µM -0.298414219849419 0.403533071119788 no 2032 0.382693518669039 3126 2989616
SGTC_1105 epirubicin 18.1 µM -0.300023316713597 0.402908875684189 no 2033 0.382079685131688 2909 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_224 benfluorex 43.875 µM -0.300190957413479 0.402843859269454 no 2034 0.382015751066758 3038 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_681 1642-0006 26.6 µM -0.300286483436509 0.402806812429847 no 2035 0.381979321215624 3022 4446530
SGTC_1565 sinapyl alcohol 95.1 µM -0.301453714047261 0.402354208389791 no 2036 0.381534270061044 3028 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2262 9014885 67.46 µM -0.302597209623842 0.401910934717933 no 2037 0.38109842061668 2929 6457424
SGTC_2265 7929201 200 µM -0.30282153543829 0.401823990067881 no 2038 0.381012935310245 2890 1265108
SGTC_549 1661-1316 519 µM -0.302932904862903 0.401780827087065 no 2039 0.380970497191472 3080 2857282
SGTC_1815 st051655 58.2 µM -0.303301686443268 0.401637908511389 no 2040 0.3808299805453 3031 5984156
SGTC_2065 5221596 34.26 µM -0.304728095084418 0.401085238395544 no 2041 0.380286624944427 3066 788581
SGTC_2448 5185112 27.17 µM -0.305019171498047 0.400972483462466 no 2042 0.380175775456123 3077 5718189
SGTC_480 am 92016 50 µM -0.306323266385008 0.400467414646426 no 2043 0.379679263054421 3011 2129 K+ channel blocker.
SGTC_2149 5554786 194.827 µM -0.307208696194004 0.40012458730565 no 2044 0.37934226338798 2958 745063 YPR165W RHO1
SGTC_229 benomyl 22.8748 µM -0.309825548595573 0.399111825547898 no 2045 0.378346810992852 3021 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_859 0439-0102 54.6 µM -0.3106623259434 0.398788122851313 no 2046 0.378028670268892 3092 610143
SGTC_346 4513-0042 7.16 µM -0.310738395573238 0.398758699183253 no 2047 0.37799975287692 2937 2827372
SGTC_2045 5106652 78.05 µM -0.311034945019732 0.398643999605043 no 2048 0.377887027995271 3070 673349
SGTC_1913 st060213 96.1 µM -0.312007185293056 0.398268017357557 no 2049 0.377517531330911 3148 688959
SGTC_2556 citropten 84.59 µM -0.313994596930756 0.397499744814646 no 2050 0.376762571211452 2986 2775 A potential DNA crosslinker.
SGTC_306 1672-3436 11.6 µM -0.31454929221757 0.397285387401172 no 2051 0.376551942492462 3056 6797378
SGTC_641 4092-0595 30 µM -0.315454597281489 0.396935606388064 no 2052 0.376208259294279 3038 786260
SGTC_573 3702-0553 84.7 µM -0.316068031727359 0.396698641974161 no 2053 0.375975435422046 2975 1222756
SGTC_862 0452-0056 10.2 µM -0.316558020183558 0.396509391074869 no 2054 0.375789496856824 3041 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_682 0kpi-0099 17 µM -0.316641313123653 0.39647722281394 no 2055 0.375757892101795 3045 1714895 YML126C ERG13
SGTC_2877 9040724 71.43 µM -0.317120044129882 0.396292347538341 no 2056 0.375576258107483 3161 6463895
SGTC_3019 9081971 49.47 µM -0.318182038794712 0.395882312095863 no 2057 0.375173428158303 3129 16451803
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.318304326917547 0.395835104118971 no 2058 0.375127051233397 2944 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_20 0481-0013 4.944 µM -0.318867465106377 0.39561773058009 no 2059 0.374913508276172 3001 182045
SGTC_1738 st035555 74 µM -0.319648343512312 0.395316362202596 no 2060 0.374617461317252 3089 5331140
SGTC_2271 7849410 118.62 µM -0.319891314882099 0.395222603785772 no 2061 0.374525360970395 3097 972430
SGTC_3111 9122088 49.47 µM -0.320949544250074 0.394814322320695 no 2062 0.37412431374801 3009 16876704
SGTC_2218 6965428 192.983 µM -0.320985791199393 0.394800339723012 no 2063 0.374110579307749 3049 675684
SGTC_830 4076-0286 57.8 µM -0.321590629524254 0.394567037725044 no 2064 0.373881421797053 2965 6866659
SGTC_1840 st055363 71 µM -0.321959909077138 0.394424615504955 no 2065 0.373741533286405 3003 676033
SGTC_1092 toremifene 6.32 µM -0.323929961595699 0.393665052653796 no 2066 0.372995529939349 2965 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2806 7952793 58.44 µM -0.32472337393041 0.393359262934245 no 2067 0.372695221341868 3118 2972490
SGTC_2670 beta-carotene 100 µM -0.326917606246582 0.392513925008363 no 2068 0.37186510213445 3088 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_3201 9113999 49.47 µM -0.328467754093684 0.391917028811356 no 2069 0.371279010751103 3169 16649224
SGTC_2493 resveratrol 26.09 µM -0.32890278843597 0.391749561171733 no 2070 0.371114583302376 2940 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_169 k015-0017 16.025 µM -0.330650079754772 0.391077139028303 no 2071 0.3704544068475 3226 1840002
SGTC_1645 Cervolide 78 µM -0.3318717033032 0.39060720642829 no 2072 0.3699930690368 3035 23173 A fragrance.
SGTC_761 k216-0224 480 µM -0.33235914207943 0.390419743643741 no 2073 0.369809043262352 3178 1340404
SGTC_2232 chlorophetanol 41.5365 µM -0.33291106737989 0.390207510910242 no 2074 0.369600707481117 3081 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_3213 9129884 49.47 µM -0.333467566662578 0.389993552461616 no 2075 0.369390683908163 3073 17190742
SGTC_3329 9141233 27.5565 µM -0.334301975582432 0.389672807970902 no 2076 0.36907584990854 3145 4909101 YNL103W MET4
SGTC_2078 5212016 200 µM -0.335130119128305 0.389354546151786 no 2077 0.368763466742942 3034 1899708
SGTC_3235 9132602 49.47 µM -0.335308785887229 0.389285892891188 no 2078 0.368696083402446 3112 4912240
SGTC_1764 st044502 93.5 µM -0.335472589528227 0.389222953866563 no 2079 0.368634309164948 3125 8407
SGTC_3102 9121669 49.47 µM -0.336120261113691 0.388974124519989 no 2080 0.368390090110425 3015 41905072
SGTC_1910 st062352 60.4 µM -0.336302599547283 0.388904080014141 no 2081 0.368321344912334 2934 2245730
SGTC_3247 9135149 49.47 µM -0.336578043948373 0.388798276109339 no 2082 0.368217504916147 3009 8934436 YOR116C RPO31
SGTC_1325 1431-0015 227 µM -0.337286036013601 0.388526359541987 no 2083 0.367950642632213 2999 1103340
SGTC_3085 9117376 49.47 µM -0.338296205450251 0.388138481129279 no 2084 0.367569991472912 3071 16480349
SGTC_3280 9140961 49.47 µM -0.338411765252316 0.388094116317667 no 2085 0.367526454613619 2980 4901226
SGTC_2143 5623677 140.463 µM -0.338602153801658 0.388021027026359 no 2086 0.367454729928972 3037 5375313
SGTC_1101 ebselen 5.29 µM -0.338897944162271 0.387907482331862 no 2087 0.36734330661046 3152 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2610 ononetin 44.17 µM -0.341047384954148 0.387082667461067 no 2088 0.366533954891134 3050 259632
SGTC_1028 k015-0029 4.8 µM -0.341276419874712 0.386994808809155 no 2089 0.366447748852712 2987 4588309
SGTC_1854 st056233 32.9 µM -0.341999023936478 0.386717653158141 no 2090 0.366175813403025 3115 5393174
SGTC_1137 ixabepilone 100 µM -0.342015220229343 0.38671144171204 no 2091 0.366169719069486 2960 154225 A novel microtubule stabilizer.
SGTC_19 0279-0214 38.434 µM -0.343873205922617 0.385999077950634 no 2092 0.365470821500237 3019 3566274 YBR002C RER2
SGTC_2996 9066192 71.4286 µM -0.344431723310327 0.385785013760369 no 2093 0.365260817464824 3044 6472854
SGTC_1292 0kpi-0043 232 µM -0.346218565046836 0.385100400896481 no 2094 0.364589231807179 3051 3333905
SGTC_2084 5306078 60.6385 µM -0.346261187469189 0.385084074849354 no 2095 0.364573217205646 3032 679340
SGTC_3110 9122132 49.47 µM -0.346681179956406 0.384923212273048 no 2096 0.364415425295074 3170 918317
SGTC_509 pifithrin 175 µM -0.346816938030013 0.384871219402256 no 2097 0.364364425661785 3110 4817 A p53 inhibitor.
SGTC_1410 3909-8106 77.9 µM -0.350148379452845 0.383595988862625 no 2098 0.363113672312956 3121 1039210
SGTC_729 4092-0585 94.1 µM -0.350926773527015 0.383298211240698 no 2099 0.362821642450304 3001 2169061
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.352158531721996 0.382827138354857 no 2100 0.362359687143628 3170 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_636 0kpi-0074 126 µM -0.352267843531399 0.382785341571003 no 2101 0.362318700803782 3082 616434
SGTC_2308 7584454 197.62 µM -0.353123758346039 0.382458118697684 no 2102 0.361997831100595 3204 893577
SGTC_3251 9135047 49.47 µM -0.354799987536866 0.381817526546979 no 2103 0.361369718857816 3108 17682963
SGTC_741 4582-0002 126 µM -0.355078654918495 0.381711061600959 no 2104 0.361265333502259 3013 2912688
SGTC_1221 2958-7315 257 µM -0.356190310829009 0.381286442282429 no 2105 0.360849023794511 3118 4562705
SGTC_2826 7992541 19.48 µM -0.356295252063265 0.381246365241019 no 2106 0.360809732321387 3009 2985066
SGTC_3062 9077494 49.47 µM -0.356600468500448 0.381129810369928 no 2107 0.360695463348585 3146 16459633
SGTC_2712 st079126 47.7 µM -0.357326073319226 0.380852762517837 no 2108 0.360423856503241 3018 3152970
SGTC_1442 4112-3290 3 µM -0.359636339658799 0.37997107227768 no 2109 0.359559552138593 3028 704353
SGTC_683 panaxydol 45 µM -0.360531855042421 0.379629475137987 no 2110 0.359224719587528 3061 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_690 glyoxal 20.3 µM -0.36123878197703 0.3793598819731 no 2111 0.358960476449414 3093 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_460 trequinsin 123 µM -0.363388280273895 0.378540511594752 no 2112 0.358157427640159 3117 5537 A vasodilator.
SGTC_1450 4112-4260 37.6 µM -0.363832958355071 0.378371072118588 no 2113 0.35799137485417 3184 1633175
SGTC_3353 9151644 39.2805 µM -0.364264329249798 0.378206725537722 no 2114 0.357830316939749 3159 4909158
SGTC_1948 st076329 66.6 µM -0.365520155357163 0.377728398015235 no 2115 0.357361582152224 2979 24208413
SGTC_806 3966-4455 5.86 µM -0.36578136855214 0.377628928894739 no 2116 0.357264111811175 3060 714982
SGTC_202 3594-0513 34.79 µM -0.366184244959986 0.377475530803426 no 2117 0.35711379884102 3062 708429
SGTC_2388 9080168 200 µM -0.367811445645868 0.376856159330879 no 2118 0.356506917001584 3029 15943073
SGTC_1797 st048695 56.8 µM -0.368704717374872 0.376516282359691 no 2119 0.356173916081449 3166 592262 YIL048W NEO1
SGTC_352 k048-0007 5.11 µM -0.368849950003265 0.376461032483865 no 2120 0.356119785467887 3150 6811911
SGTC_2504 purpurogallin 52.29 µM -0.369484695753776 0.376219590126931 no 2121 0.355883239224296 3019 5281571 An antioxidant.
SGTC_3000 9075062 71.4286 µM -0.370154509516436 0.375964861243827 no 2122 0.355633684584354 3054 17057871
SGTC_844 0330-0132 15.3 µM -0.371109121459696 0.375601917567721 no 2123 0.355278128720521 3181 2828079
SGTC_602 3130-1533 38.1 µM -0.37121008850429 0.375563536304896 no 2124 0.355240529778484 3162 720941
SGTC_3234 9132280 49.47 µM -0.371222809350511 0.375558700733791 no 2125 0.355235792784645 3128 17612295
SGTC_314 1671-0008 2.74 µM -0.371372616785306 0.375501755953565 no 2126 0.3551800091148 3075 3913060
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.373637777781558 0.374641054506336 no 2127 0.354336911844623 3122 5379071
SGTC_2067 5224629 34.075 µM -0.37367383611262 0.374627358327224 no 2128 0.354323496622116 3204 2835000
SGTC_1262 0737-0114 49.6 µM -0.373861904730283 0.374555926041261 no 2129 0.354253530081341 3227 765919
SGTC_222 nsc-310342 10.666 µM -0.375370734257558 0.37398299790042 no 2130 0.353692383490822 3161 432556
SGTC_655 k060-0012 42 µM -0.376436857037351 0.373578340711739 no 2131 0.353296074823537 3062 5994525
SGTC_3002 9075603 71.4286 µM -0.378003399482337 0.372983997317903 no 2132 0.352714034300823 3101 20105405
SGTC_1848 st056003 16.4 µM -0.378790891757871 0.372685338201314 no 2133 0.352421575791964 3170 146492
SGTC_2598 perillyl alcohol 100 µM -0.379111988565904 0.372563583099895 no 2134 0.352302352036398 3222 10819 An apoptosis inducer.
SGTC_983 1491-0821 12.2 µM -0.379724706818094 0.372331284854733 no 2135 0.352074889051553 3175 46495113
SGTC_1834 st055981 52.8 µM -0.380619446929443 0.371992147860896 no 2136 0.351742824516749 3233 471719 YDL150W RPC53
SGTC_2795 7780010 54.55 µM -0.385765089021625 0.370043708907061 no 2137 0.349835326338375 3224 953673
SGTC_3308 9128332 17.569 µM -0.38666876014544 0.369701868960994 no 2138 0.349500723197809 3229 17332805 YDL196W YDL196W
SGTC_264 promethazine 12.5 mM -0.387106465948133 0.369536330973687 no 2139 0.349338695475041 3201 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1025 k007-0731 70 µM -0.388506608211433 0.369006967204292 no 2140 0.348820582369247 3063 6256118
SGTC_2432 5630864 12.22 µM -0.388572857878959 0.36898192577171 no 2141 0.348796074105635 3213 5714970
SGTC_1329 1447-1697 50.6 µM -0.388973491983844 0.368830503628773 no 2142 0.34864787780887 3169 2840515
SGTC_3343 9148379 18.9835 µM -0.389001745106487 0.368819825954206 no 2143 0.348637427727441 3230 1955036
SGTC_2648 atorvastatin 78.68 µM -0.390329549306701 0.368318124565743 no 2144 0.348146437793842 3191 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2258 7960471 200 µM -0.39184371089424 0.367746283299771 no 2145 0.347586847908992 3150 2974708
SGTC_1721 st082152 9.2685 µM -0.392748320001472 0.367404786579799 no 2146 0.347252689125141 3072 5296051
SGTC_548 1436-0017 110 µM -0.392917369885385 0.367340980599876 no 2147 0.347190255968779 3238 9677137
SGTC_333 3486-0131 40.1 µM -0.393644715269769 0.367066494056064 no 2148 0.34692168158629 3230 6744690
SGTC_3093 9117344 49.47 µM -0.395311390261304 0.366437778479658 no 2149 0.346306547174512 3228 24824913
SGTC_961 1252-1571 372 µM -0.395562367857224 0.366343133835755 no 2150 0.346213951726974 3264 6813498
SGTC_1628 st004252 77.7 µM -0.395953913254873 0.366195496753256 no 2151 0.346069513679929 3220 692968
SGTC_1972 st070201 17.4 µM -0.39616967424469 0.366114149839612 no 2152 0.345989930699257 3223 2829099
SGTC_1602 st001878 87.6 µM -0.397129707604516 0.365752267923014 no 2153 0.345635906956983 3252 595405 YLR310C CDC25
SGTC_735 3076-0345 636 µM -0.397557801526098 0.365590937587397 no 2154 0.345478085709872 3258 2888990
SGTC_907 3448-6986 75.5 µM -0.397773051859981 0.365509827899733 no 2155 0.345398741596086 3283 590582
SGTC_657 3534-0529 86.7 µM -0.398632665733542 0.365185971960914 no 2156 0.345081944343755 3237 1049549
SGTC_3211 9128781 49.47 µM -0.399224887403191 0.364962910826985 no 2157 0.344863753441743 3163 17194361
SGTC_2003 4023581 200 µM -0.399970339843103 0.364682200067351 no 2158 0.344589181404612 3231 16641307
SGTC_2190 6049624 200 µM -0.400465536105493 0.36449576693033 no 2159 0.344406831310576 3183 2265554
SGTC_1070 indatraline 8.81 µM -0.402720439047544 0.363647239381532 no 2160 0.34357694805492 3131 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1653 st012112 65 µM -0.40295709258118 0.363558224546266 no 2161 0.34348989488179 3264 720429
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.404129968166907 0.363117168043011 no 2162 0.343058574350253 3179 75037 A free radical scavenger.
SGTC_709 3807-1509 243 µM -0.404765650720342 0.362878197229175 no 2163 0.342824889889664 3170 1886677 YPL242C IQG1
SGTC_2736 butenafine 14.65 µM -0.404934240150468 0.36281482871036 no 2164 0.342762924495026 3126 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2507 purpurin 79.67 µM -0.406206463399295 0.362336753295463 no 2165 0.342295452710051 3097 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2490 carminic acid 95.39 µM -0.407639253696018 0.361798597052493 no 2166 0.341769270601132 3212 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3091 9116372 49.47 µM -0.407663799478078 0.361789380030372 no 2167 0.341760259010358 3271 17169793
SGTC_105 0111-0055 734.78 µM -0.407870882325416 0.361711622930157 no 2168 0.341684235449386 3191 5179370
SGTC_1594 piperine 70.1 µM -0.408239460187419 0.361573240535032 no 2169 0.34154894026608 3113 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_964 1287-0107 19.4 µM -0.410178459390493 0.360845542661236 no 2170 0.340837520535329 3276 51516812 YPR165W RHO1
SGTC_1211 1056-0033 32.3 µM -0.41057452062597 0.360696964460356 no 2171 0.340692274970006 3253 6741922
SGTC_2878 9043973 25.97 µM -0.411931005142395 0.360188253022003 no 2172 0.34019499722987 3260 6465167
SGTC_1583 clindamycin 39.6 µM -0.411969101393448 0.360173969660901 no 2173 0.340181035417382 3122 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1365 1672-3266 55.4 µM -0.412304774452621 0.360048124783856 no 2174 0.340058024798603 3224 6415873
SGTC_538 2922-0838 53.3 µM -0.412324549674839 0.360040711464286 no 2175 0.340050778509229 3294 777039
SGTC_2885 9057732 51.95 µM -0.412448473966704 0.359994256022976 no 2176 0.340005369933571 3267 6471414
SGTC_2200 6600604 21.907 µM -0.41469347513652 0.359153032140572 no 2177 0.339183154752325 3132 2904777
SGTC_1817 st052116 64.4 µM -0.414901902106422 0.359074967075143 no 2178 0.339106858667835 3259 4361398
SGTC_2433 5607874 27.82 µM -0.415398440849432 0.358889015193526 no 2179 0.338925123930172 3124 2252428
SGTC_100 0086-0128 49.5915 µM -0.416472582277414 0.358486867741108 no 2180 0.338532113087118 3175 93297
SGTC_3303 9125618 40.5795 µM -0.417024134224561 0.358280433321041 no 2181 0.338330377495821 3191 22695467
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.417076912218871 0.358260681785984 no 2182 0.338311075852728 3223 616764
SGTC_580 1123-0028 41 µM -0.417525416157314 0.358092849845913 no 2183 0.338147068904875 3145 1677248 YPR107C YTH1
SGTC_2706 st078239 82.5 µM -0.418049335615801 0.357896831845346 no 2184 0.33795552323236 3191 15434492
SGTC_458 nppb 133 µM -0.419118084511125 0.357497088836993 no 2185 0.337564917281692 3317 4549 A chloride channel blocker.
SGTC_3266 9136860 49.47 µM -0.419383347048725 0.357397897166444 no 2186 0.337467996309524 3225 4871271 YPR165W RHO1
SGTC_1328 1441-0025 69.2 µM -0.419889703129709 0.357208578275748 no 2187 0.337283015110956 3127 4562601
SGTC_2817 7995342 71.43 µM -0.420043727779134 0.357150997755091 no 2188 0.337226754869449 3072 18879975
SGTC_2749 bexarotene 57.39 µM -0.421706371976864 0.356529642773324 no 2189 0.336619676451276 3199 82146 An retinoic acid receptor inhibitor.
SGTC_22 0964-0034 14.468 µM -0.42202388757469 0.356411025681369 no 2190 0.336503790872595 3201 138402
SGTC_3115 9123671 49.47 µM -0.422916798776806 0.356077527481398 no 2191 0.336177982960083 3272 3286988
SGTC_3279 9140807 49.47 µM -0.423394025281413 0.355899330712427 no 2192 0.336003901658903 3196 45595718
SGTC_365 0121-0052 13.6 µM -0.423651850403851 0.355803071694256 no 2193 0.335909867589207 3262 3101739
SGTC_17 0960-0276 49.807 µM -0.425273800180126 0.355197727739941 no 2194 0.335318545238117 3150 6821114
SGTC_762 1165-0429 115 µM -0.426759987324378 0.354643373693714 no 2195 0.334777076490564 3254 5967793
SGTC_1184 1269-1718 139 µM -0.426797007293331 0.354629569012925 no 2196 0.334763593229535 3281 5403821
SGTC_1611 st001856 99.4 µM -0.428589322362495 0.353961446594046 no 2197 0.334111058714935 3189 647478
SGTC_1666 st014829 29 µM -0.428773591576887 0.353892781886753 no 2198 0.334043999543871 3144 3858230
SGTC_3311 9131146 2.8755 µM -0.428784027794759 0.35388889315444 no 2199 0.334040201758587 3182 4900406 YPR165W RHO1
SGTC_1687 st020778 55.3625 µM -0.429566330341965 0.353597435840009 no 2200 0.333755566850852 3159 4259299
SGTC_840 0245-0196 390 µM -0.432804351763517 0.35239198177944 no 2201 0.332578455790235 3305 3827528
SGTC_3274 9138298 49.47 µM -0.434253245620155 0.35185306495609 no 2202 0.332052275730569 3172 17015756
SGTC_2014 4013930 200 µM -0.434514320176799 0.351755989741154 no 2203 0.331957499101199 3284 64556
SGTC_194 1486-1323 56.904 µM -0.434709635795815 0.351683371956529 no 2204 0.331886601649623 3204 5178754
SGTC_2924 9010168 62.78 µM -0.436657600601336 0.350959420754708 no 2205 0.331179841294528 3256 2993929
SGTC_468 gf-109203x 121 µM -0.437320190991987 0.350713295509284 no 2206 0.330939577180893 3194 2396 A protein kinase C inhibitor.
SGTC_908 3448-7491 47.7 µM -0.437401742888754 0.350683006640759 no 2207 0.330910010184675 3155 1203031
SGTC_2419 paclitaxel 166.5 µM -0.437923752383052 0.350489151640469 no 2208 0.330720778351616 3184 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1140 3229-1848 2.98 µM -0.438529939344496 0.350264085103737 no 2209 0.330501085920911 3276 2849525
SGTC_1927 st060202 13.8 µM -0.438988746283885 0.350093773121192 no 2210 0.33033484532874 3312 688887
SGTC_565 1418-0001 44.5 µM -0.440032034495291 0.349706610327246 no 2211 0.329956952934168 3320 2862145
SGTC_2689 tacrolimus 100 µM -0.440285849490863 0.349612443552998 no 2212 0.329865044099772 3232 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_626 0214-0009 33 µM -0.442275475269974 0.348874602276226 no 2213 0.329144937776864 3300 3437874
SGTC_101 0490-5701 117.494 µM -0.442733387152542 0.348704869033783 no 2214 0.328979295062875 3245 4661669
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.44389789518514 0.348273359746759 no 2215 0.328558203192312 3298 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1282 0886-0010 32.4 µM -0.444579261463637 0.348020969987932 no 2216 0.328311918658395 3357 2836211 YNL267W PIK1
SGTC_297 0986-0032 24 µM -0.445158440481581 0.347806485063015 no 2217 0.328102629061741 3184 2847425
SGTC_3242 9133940 49.47 µM -0.446124956960381 0.347448667550556 no 2218 0.32775349306483 3309 17248444
SGTC_2526 patulin 37.61 µM -0.446465629016856 0.347322578508664 no 2219 0.327630467519185 3320 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_3224 9130643 49.47 µM -0.447852244279312 0.346809540962532 no 2220 0.327129917847005 3360 17644395
SGTC_3270 9137563 49.47 µM -0.448198541700026 0.346681457216977 no 2221 0.327004957546653 3249 17015724
SGTC_2118 5526350 200 µM -0.449154244202 0.346328066017326 no 2222 0.326660196052101 3281 743594
SGTC_1100 amiodarone 5.07 µM -0.449435087926675 0.346224243525561 no 2223 0.326558912200148 3285 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_755 1995-0008 37.3 µM -0.449604368135625 0.346161669488404 no 2224 0.326497868936317 3303 689533
SGTC_228 caffeine 993.056 µM -0.449675904792907 0.346135227391035 no 2225 0.326472073867358 3283 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1438 4092-1045 4 µM -0.450033587295606 0.346003028447957 no 2226 0.32634311125377 3208 1351342
SGTC_2056 5235370 200 µM -0.450189100465469 0.345945556854884 no 2227 0.326287047372546 3173 5511916
SGTC_1390 3413-2614 145 µM -0.450759596782938 0.345734754098033 no 2228 0.326081411992448 3238 3421432
SGTC_2960 9079389 5.97 µM -0.451009782445794 0.34564232365975 no 2229 0.325991249252717 3328 16457355
SGTC_1474 0330-0125 5.35 µM -0.451654054474038 0.345404341412443 no 2230 0.325759111201339 3302 X1474
SGTC_1604 st002052 72.4 µM -0.451816299910881 0.345344420557141 no 2231 0.325700663090775 3327 6254834 YHR062C RPP1
SGTC_2738 aclarubicin 5.55 µM -0.451911965547189 0.345309090922309 no 2232 0.325666202029566 3212 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2018 5133068 143 µM -0.453205617188343 0.344831473570471 no 2233 0.325200344009615 3167 785362
SGTC_1111 tnp00062 510.699 nM -0.453411218638736 0.344755588073674 no 2234 0.325126329822506 3344 676306
SGTC_1431 4049-0260 9.09 µM -0.454697647272953 0.344280921668405 no 2235 0.324663386859995 3247 3854841
SGTC_603 3794-0023 45.9 µM -0.45485706286971 0.344222117565183 no 2236 0.324606037318261 3283 3802260
SGTC_2850 9015429 58.44 µM -0.45635647827236 0.34366920824046 no 2237 0.324066828341678 3230 6457570
SGTC_3160 9100216 49.47 µM -0.456806144675413 0.343503458884438 no 2238 0.3239051943943 3270 17191039
SGTC_2180 6301957 200 µM -0.457655739786593 0.343190375892823 no 2239 0.323599895501862 3306 845462
SGTC_1909 st060837 51.5 µM -0.457875347877368 0.343109465944966 no 2240 0.323520999435482 3216 678937
SGTC_3148 9097893 49.47 µM -0.458290742426763 0.342956442296321 no 2241 0.323371787122209 3162 17174100
SGTC_3138 9097216 49.47 µM -0.459123329536747 0.342649810212291 no 2242 0.323072802176132 3285 25237486
SGTC_391 gliotoxin 8.33 µM -0.461172714421078 0.341895487671959 no 2243 0.32233734802693 3362 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1968 st069590 43.6 µM -0.461547533064948 0.341757595315565 no 2244 0.322202913515992 3289 6384066
SGTC_233 rapamycin 362 pM -0.461942290067133 0.341612390644562 no 2245 0.322061352947517 3302 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_350 k064-0020 19.8 µM -0.464906251045595 0.340522897718182 no 2246 0.320999296902748 3367 2790705
SGTC_774 k060-0086 136 µM -0.468243556965269 0.339297761876201 no 2247 0.319805213452504 3375 5911235
SGTC_2009 4012297 12.05 µM -0.468343349642114 0.339261153726272 no 2248 0.319769536428738 3297 45595307
SGTC_2361 9034121 116 µM -0.469137461189154 0.338969894318323 no 2249 0.31948569191503 3230 6496917
SGTC_1560 lithocholic acid 53.1 µM -0.470296706262372 0.338544886261001 no 2250 0.31907152518302 3283 9903 A bile acid which acts as a detergent.
SGTC_2088 5278280 127.392 µM -0.471133504923784 0.338238222775359 no 2251 0.318772700044167 3340 791502
SGTC_2986 9022445 71.43 µM -0.471881680856264 0.337964127889179 no 2252 0.318505622271937 3339 6459286
SGTC_1278 0874-0585 172 µM -0.471885258190737 0.337962817535866 no 2253 0.318504345490479 3276 766306
SGTC_685 1278-0033 54.9 µM -0.471926610537075 0.33794767059489 no 2254 0.318489586638684 3358 3590572
SGTC_2707 st078556 66.6 µM -0.472279153389583 0.337818548414221 no 2255 0.318363774091371 3269 17250899
SGTC_1932 st074806 40.9 µM -0.473212167359215 0.337476915272935 no 2256 0.31803090896485 3432 17251235
SGTC_1952 st077036 64.1 µM -0.474599843424863 0.336969050461122 no 2257 0.317536108942673 3306 2937007
SGTC_35 0133-0054 64.071 µM -0.474906948598046 0.336856695531185 no 2258 0.317426649253857 3260 99677
SGTC_1765 st044815 90.4 µM -0.475248772061649 0.33673165597623 no 2259 0.317304833901636 3294 645695
SGTC_1351 1496-0003 46.5 µM -0.475807953231626 0.336527145546061 no 2260 0.31710560162525 3354 3891978
SGTC_3100 9120536 49.47 µM -0.476040747436429 0.336442019513039 no 2261 0.317022674327475 3269 16421196
SGTC_1964 st076914 61 µM -0.47606770334644 0.336432163066488 no 2262 0.317013072530914 3300 24208661
SGTC_3098 9119039 49.47 µM -0.476194774421324 0.336385700956785 no 2263 0.316967810995559 3330 17161528
SGTC_370 0180-0345 38.7 µM -0.476600561076183 0.33623734636065 no 2264 0.31682329190211 3163 3989527
SGTC_2382 9035899 200 µM -0.476638035084699 0.336223647241738 no 2265 0.316809947111723 3241 6462679
SGTC_1521 st012942 49.4 µM -0.476939150448721 0.336113578438025 no 2266 0.31670272620626 3381 24207259
SGTC_3130 9127414 49.47 µM -0.477121546734735 0.336046912680959 no 2267 0.316637786177817 3314 1494646
SGTC_2770 toltrazuril 17.5 µM -0.478033028581078 0.33571384380586 no 2268 0.316313348622235 3351 68591 Kills coccidiodes.
SGTC_2363 9053361 176 µM -0.478278253879143 0.335624256888495 no 2269 0.316226085981666 3410 6469797 YMR079W SEC14
SGTC_392 N-ethylmaleimide 8.33 µM -0.479185396773708 0.335292936201937 no 2270 0.315903371058027 3224 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2727 riluzole 51.77 µM -0.479248860705191 0.335269761719028 no 2271 0.315880799092456 3299 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.48070050880437 0.334739849364476 no 2272 0.315364684736864 3319 364106
SGTC_2649 anisomycin 9.56 µM -0.480914471366242 0.334661771858714 no 2273 0.315288643590047 3322 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2435 5706476 10.6 µM -0.483338170418404 0.333777834823456 no 2274 0.314427820881023 3373 5725375
SGTC_1058 3448-5425 97.3 µM -0.484154599875248 0.333480285567503 no 2275 0.314138077199706 3313 7279705
SGTC_2662 daunorubicin 22.37 µM -0.484384211475732 0.333396622047909 no 2276 0.314056610672692 3264 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1269 0831-0796 3.05 µM -0.484889730859071 0.333212455292652 no 2277 0.313877283602851 3360 927758
SGTC_435 c-PAF 6.7 µM -0.485893651840514 0.332846834124124 no 2278 0.313521284759763 3330 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2903 5923464 63.88 µM -0.486730355879789 0.332542233595048 no 2279 0.313224715087583 3342 2876576
SGTC_1741 st038134 10.228 µM -0.487114942086007 0.332402262778978 no 2280 0.313088439039169 3463 1272587
SGTC_767 0929-0023 86 µM -0.488467148903022 0.33191031040634 no 2281 0.312609494611747 3370 1204563
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.489502772623629 0.331533731349743 no 2282 0.312242896039923 3278 2374 Ca(2+)-ATPase inhibitor.
SGTC_2094 5332512 191.667 µM -0.490147937167422 0.331299219182757 no 2283 0.31201460931476 3384 755774
SGTC_742 0kpi-0133 140 µM -0.490502313986081 0.331170434171523 no 2284 0.311889246392977 3376 2728852
SGTC_2289 7946404 165.07 µM -0.491800601673548 0.330698790707943 no 2285 0.311430155576388 3257 1246120 YPR165W RHO1
SGTC_2541 muurolladie-3-one 83.07 µM -0.492294333064515 0.330519497867289 no 2286 0.311255642839393 3417 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_337 1315-0038 354 µM -0.492296742168373 0.330518623124414 no 2287 0.311254791429109 3288 1626437
SGTC_1139 k015-0024 46.9 µM -0.492547647761912 0.33042752465874 no 2288 0.31116612348717 3363 2766652
SGTC_1874 staurosporine 7.6 µM -0.495701493735444 0.32928328894361 no 2289 0.310052516527925 3365 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2528 xanthyletin 44.79 µM -0.496011804389396 0.329170792363831 no 2290 0.309943041281814 3244 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2768 sulfasalazine 50.2 µM -0.496552411916342 0.328974843461036 no 2291 0.309752359295127 3431 5384001 An antioxidant and salicylic acid derivative.
SGTC_2868 9035608 32.47 µM -0.497204996223039 0.328738369992764 no 2292 0.309522249269537 3303 6462614
SGTC_921 1561-0023 372 µM -0.497553824263371 0.328611995160136 no 2293 0.309399278411131 3307 24050882
SGTC_3188 9110789 49.47 µM -0.498745721867627 0.328180337647478 no 2294 0.308979264948118 3421 849217
SGTC_962 1254-0300 21.5 µM -0.499993016479694 0.327728863118094 no 2295 0.308539997385638 3295 7340576
SGTC_853 0419-0306 21 µM -0.502282679783343 0.326900745165931 no 2296 0.307734345465334 3272 762713
SGTC_1651 st011928 86.1 µM -0.50342005192782 0.326489700497446 no 2297 0.307334488289672 3368 720198
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.503599748072422 0.326424777818866 no 2298 0.307271334826038 3366 17037758
SGTC_1357 1503-1303 39.5 µM -0.504266571761255 0.326183906099078 no 2299 0.307037032373134 3313 292895
SGTC_414 piperonyl butoxide 100 µM -0.504296078768906 0.326173249178155 no 2300 0.307026666288111 3266 5794 A potent inhibitor of cytochrome P450.
SGTC_2438 5259590 200 µM -0.504575873055775 0.326072204116554 no 2301 0.306928379631066 3350 1201127
SGTC_789 1309-1135 70.6 µM -0.504999274982095 0.325919320797536 no 2302 0.30677967260205 3378 3092424
SGTC_3047 9092122 49.47 µM -0.506498962466566 0.325378044388 no 2303 0.306253208928437 3332 17173831
SGTC_2772 vinpocetine 57.06 µM -0.507711696364076 0.324940606167063 no 2304 0.305827772291277 3457 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1169 aniline yellow 25.8 µM -0.50791859140556 0.32486600232737 no 2305 0.305755218011088 3302 6051 A DNA damaging agent.
SGTC_1743 st037606 46.3785 µM -0.508219637118158 0.324757461444163 no 2306 0.305649660442925 3289 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1993 st073995 70.8 µM -0.50992039948209 0.324144537740515 no 2307 0.305053614878434 3321 3098394
SGTC_1417 3966-0327 90.4 µM -0.509976549704204 0.324124310339262 no 2308 0.305033945394808 3353 651118
SGTC_2412 st077135 33.4 µM -0.510759552847096 0.323842297565139 no 2309 0.304759717255841 3493 13258915
SGTC_2037 5169046 200 µM -0.513426006504571 0.322882685081991 no 2310 0.30382667882455 3390 5718022
SGTC_1406 3909-7906 11.9 µM -0.515917284091093 0.321987179699149 no 2311 0.302956090889965 3381 X1406
SGTC_260 nsc-65238 3.989 µM -0.515928429495426 0.321983175730155 no 2312 0.302952198588903 3366 3246252
SGTC_2331 7980721 200 µM -0.517314663917637 0.321485334446384 no 2313 0.302468259621636 3312 2981221
SGTC_1768 st044301 37.178 µM -0.519567111605597 0.320677091855997 no 2314 0.301682662887095 3323 3931349
SGTC_2087 5276107 200 µM -0.519568415053193 0.320676624387311 no 2315 0.301682208543301 3354 144405
SGTC_2484 5809818 12.04 µM -0.519908157709038 0.320554788717965 no 2316 0.301563794661968 3332 2870548
SGTC_1614 st002383 48.6 µM -0.523626601319637 0.319222577658194 no 2317 0.300269137856626 3408 1947235
SGTC_3200 9114385 49.47 µM -0.524524094308492 0.318901380360352 no 2318 0.299957032982662 3418 17018030 YLR208W SEC13
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.525287257105316 0.318628364471686 no 2319 0.299691757236202 3391 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1412 3909-8563 178 µM -0.525382635128823 0.318594250600493 no 2320 0.299658611262442 3448 23767530
SGTC_1965 Pectolinarigenin 58.4 µM -0.527896876692478 0.317695536694923 no 2321 0.298785456311909 3336 5320438 An anti-inflammatory.
SGTC_970 1315-0089 19.5 µM -0.528921512033471 0.31732958896237 no 2322 0.298429949162353 3388 6811083 YLR033W RSC58
SGTC_2236 dapsone 200 µM -0.529572072062775 0.317097334561872 no 2323 0.298204331017402 3411 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_656 4090-1979 187 µM -0.529865886354925 0.316992464447155 no 2324 0.298102459918876 3446 22330961
SGTC_265 mycophenolic acid 32.932 µM -0.53170298233126 0.316337089714445 no 2325 0.297465863023466 3520 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1002 4049-0206 172 µM -0.535051850719444 0.315143881947428 no 2326 0.296307001714947 3361 4662749
SGTC_353 1988-1175 58.3 µM -0.53765782694378 0.314216699679904 no 2327 0.295406649854587 3286 2788357
SGTC_2836 9010338 19.48 µM -0.538865508666588 0.313787414425729 no 2328 0.294989829017834 3312 2994051
SGTC_827 3253-0474 693 µM -0.538961022937949 0.313753473453277 no 2329 0.294956874663988 3447 5402065
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.540495241902655 0.313208505284251 no 2330 0.294427770731879 3403 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1112 tnp00069 1.16933 µM -0.542568998074876 0.312472536799365 no 2331 0.293713294565662 3429 145826
SGTC_1615 st002656 86.5 µM -0.542726102916832 0.312416811282768 no 2332 0.293659199571638 3463 1584458
SGTC_2940 9060638 45.86 µM -0.544253808631901 0.311875153713681 no 2333 0.293133414201139 3399 4027022
SGTC_3223 9129970 49.47 µM -0.544294873203647 0.311860599621136 no 2334 0.293119287171809 3395 17248386
SGTC_2275 7947463 200 µM -0.545315449344731 0.311498981776258 no 2335 0.292768290165142 3424 1225414
SGTC_2892 9047358 58.44 µM -0.545518775617417 0.311426959457885 no 2336 0.292698385422514 3351 6466771
SGTC_2359 9039622 200 µM -0.546962324033761 0.310915832738855 no 2337 0.292202308214357 3399 6463596
SGTC_2607 solasodine 47.35 µM -0.547282878287519 0.310802381411607 no 2338 0.29209220244604 3366 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2537 larixol 68.93 µM -0.547721373875853 0.310647217134452 no 2339 0.291941616811429 3454 6708759
SGTC_940 3232-1287 54.8 µM -0.548411959506709 0.310402917582964 no 2340 0.291704533193942 3446 1585493 YIL048W NEO1
SGTC_2082 5219693 150 µM -0.548508437433398 0.310368794488587 no 2341 0.291671418688573 3417 2834649
SGTC_512 prima-1 270 µM -0.550487065479118 0.309669337627989 no 2342 0.290992673053215 3484 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1515 3460-0031 42.1 µM -0.551201611974257 0.309416910287877 no 2343 0.290747737585652 3395 2876596
SGTC_1219 1469-0211 33.1 µM -0.551707590059632 0.309238218125451 no 2344 0.29057435446266 3433 6822282
SGTC_3075 9116269 49.47 µM -0.552274375145936 0.309038104820173 no 2345 0.290380192119327 3491 17015205 YNL244C SUI1
SGTC_1240 0356-0016 42.1 µM -0.55374735465203 0.308518308914466 no 2346 0.289875880989335 3371 4305613
SGTC_2052 5265182 7.135 µM -0.556050227930788 0.307706422718908 no 2347 0.289088259324761 3446 1239884
SGTC_1064 honokiol 6.76 µM -0.556748004401438 0.307460604661315 no 2348 0.288849806790344 3413 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1997 st073024 93.8 µM -0.557691078768102 0.307128508562382 no 2349 0.288527675314014 3467 686268
SGTC_1859 st055998 20 µM -0.558433560957104 0.306867160637829 no 2350 0.288274180451384 3508 676301
SGTC_2780 5215298 71.43 µM -0.559027264007507 0.306658252400476 no 2351 0.288071556683555 3477 2834131
SGTC_48 0382-0018 55 µM -0.559449683227246 0.306509652595084 no 2352 0.287927430980145 3587 762596
SGTC_597 k018-0003 82.8 µM -0.561541437164522 0.305774278701454 no 2353 0.28721424523207 3489 6786234
SGTC_2240 6690706 185.951 µM -0.56357660965904 0.30505954736513 no 2354 0.286521154526012 3364 805876
SGTC_2481 5478948 45.16 µM -0.564103996635841 0.304874455658342 no 2355 0.286341679135994 3481 77792
SGTC_3104 9120930 49.47 µM -0.564341054442249 0.304791274122193 no 2356 0.286261023236089 3480 17014836
SGTC_698 k064-0052 127 µM -0.56508035152999 0.304531925973076 no 2357 0.286009556123585 3509 5088751
SGTC_1519 esterone 74 µM -0.565133543307714 0.304513269887841 no 2358 0.285991467334369 3369 698 A steroid.
SGTC_431 k089-0097 107 µM -0.56721751220337 0.30378275492176 no 2359 0.285283205776716 3407 5499420
SGTC_2068 5226020 147 µM -0.568541945178888 0.303318894630556 no 2360 0.284833516239228 3428 1810509
SGTC_2389 9091542 195.52 µM -0.568912771095313 0.303189075862285 no 2361 0.284707669000106 3406 3626624 YOL127W RPL25
SGTC_2858 9025781 8.96 µM -0.569820768959924 0.302871308843513 no 2362 0.284399633754251 3510 4894980 YPL153C RAD53
SGTC_160 3453-0671 289.699 µM -0.573674608618958 0.301524264478026 no 2363 0.283094006857889 3412 5322268
SGTC_895 0964-0006 13.7 µM -0.57411724037142 0.301369722777461 no 2364 0.282944233776033 3485 6738897
SGTC_3123 9126162 49.47 µM -0.574793984199472 0.301133511490131 no 2365 0.282715317887469 3466 25239884
SGTC_1553 gossypol 38.6 µM -0.574871075430835 0.301106608789527 no 2366 0.282689246595318 3428 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1573 oleylamine 1.06 µM -0.575096553033004 0.301027929580179 no 2367 0.282612999516751 3491 5356789 An amine of the fatty acid oleic acid.
SGTC_276 colchicine 750 µM -0.576175526307243 0.300651555945343 no 2368 0.282248272853506 3525 2833 A microtubule depolymerizer.
SGTC_1963 st076565 50.3 µM -0.576201315572052 0.300642562586054 no 2369 0.282239558049136 3468 4914280
SGTC_1520 flindersine 88 µM -0.577345906748943 0.300243537482779 no 2370 0.281852904011898 3560 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1173 0443-0020 122 µM -0.579532468551343 0.299481928998857 no 2371 0.281114972496128 3435 5331295
SGTC_508 roscovitine 141 µM -0.580175793865719 0.299258017113198 no 2372 0.28089803775481 3483 160355 A CDKinase inhibitor.
SGTC_1189 1431-2119 7.28 µM -0.581516745909888 0.298791537859641 no 2373 0.280446117677573 3523 3107275
SGTC_814 3342-0569 96 µM -0.582062340780364 0.298601835476992 no 2374 0.280262345168842 3545 4346283
SGTC_996 3970-0799 1.8 µM -0.582231881538079 0.29854289760891 no 2375 0.280205250702921 3537 6615648 YGL040C HEM2
SGTC_1350 1495-0454 146 µM -0.58251687858341 0.298443835315243 no 2376 0.280109287931531 3535 1069057
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.583176997123928 0.298214441782169 no 2377 0.27988707732637 3446 1241132 A phosphatase inhibitor.
SGTC_776 4476-4378 112 µM -0.583320619923141 0.298164542988196 no 2378 0.279838742019109 3486 2892008
SGTC_412 gemfibrozil 100 µM -0.583485219722381 0.298107360843452 no 2379 0.279783352020264 3478 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2956 9076196 2.52 µM -0.583633294127881 0.298055923907442 no 2380 0.279733527579087 3545 16423868
SGTC_1258 0671-0043 57.1 µM -0.584717237994394 0.297679515136892 no 2381 0.279368930642239 3454 4298767
SGTC_1905 st060207 84.5 µM -0.586866316160652 0.296933871469904 no 2382 0.278646746893144 3441 1948547
SGTC_1659 st012954 42.1 µM -0.59027785047667 0.295751964653036 no 2383 0.277502193241216 3514 24207262
SGTC_3292 9120825 59.784 µM -0.59077692315905 0.295579245128223 no 2384 0.277334949562317 3551 24824900
SGTC_2030 5175110 200 µM -0.591115350745082 0.295462148195706 no 2385 0.277221567529416 3548 2831986
SGTC_230 MPP+ 141.667 µM -0.592754920913842 0.294895154444527 no 2386 0.276672590178353 3482 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1000 4048-0884 8.67 µM -0.592925650748008 0.294836141742094 no 2387 0.276615455340323 3510 13040088
SGTC_2483 5729050 27.16 µM -0.594392036464111 0.294329510393566 no 2388 0.276124966781514 3560 2865180
SGTC_91 0417-1751 58.384 µM -0.59449740751332 0.294293120536619 no 2389 0.27608973786893 3567 6795624
SGTC_1670 st016595 4.04 µM -0.59636818739566 0.293647393553456 no 2390 0.275464643932447 3506 597879
SGTC_1220 1838-0075 193 µM -0.598863435987809 0.292787144350829 no 2391 0.274631977925114 3485 5529645
SGTC_2322 7413319 38.22 µM -0.59960629759837 0.292531265380353 no 2392 0.274384324569447 3533 1840400
SGTC_2671 danthron 100 µM -0.600515496857492 0.292218232851733 no 2393 0.274081368084344 3481 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2991 9074669 71.4286 µM -0.600684350513667 0.292160114587839 no 2394 0.274025122151591 3532 17333109
SGTC_2049 5262831 67.185 µM -0.601511489393517 0.291875496827166 no 2395 0.273749680805264 3508 763417
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.602576413484251 0.291509247680913 no 2396 0.273395257570923 3497 688667
SGTC_1012 4112-3522 18 µM -0.603627611483708 0.291147929569207 no 2397 0.273045625574203 3527 3112398
SGTC_470 aa-861 153 µM -0.604459019255604 0.29086230602075 no 2398 0.272769253608607 3480 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2673 kobusone 100 µM -0.604728237354826 0.290769846357548 no 2399 0.272679791374936 3571 6710676 An epoxy ketone and protein crosslinker.
SGTC_2514 salinomycin 42.74 µM -0.605867072440397 0.290378879484214 no 2400 0.272301513149417 3568 23682228 A polyether potassium ionophore.
SGTC_1342 1486-1464 234 µM -0.607384976752583 0.289858159550184 no 2401 0.27179772806376 3554 3253938
SGTC_871 0574-0004 149 µM -0.608663466617903 0.289419911300535 no 2402 0.271373763631946 3441 9551173
SGTC_701 4424-0219 185 µM -0.609619178055515 0.289092510378423 no 2403 0.271057052250174 3574 2911779
SGTC_465 cgp-37157 41 µM -0.610813831369922 0.288683499540827 no 2404 0.270661417812795 3456 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1870 st057514 26.5 µM -0.610958993145868 0.288633819396703 no 2405 0.270613364110729 3501 5393161
SGTC_2990 9074105 71.4286 µM -0.61218573953313 0.288214138805931 no 2406 0.270207437745018 3517 6502001
SGTC_1876 myriocin 605 nM -0.612493845515255 0.28810877831815 no 2407 0.270105534348132 3570 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2917 7979103 53.79 µM -0.613536046990052 0.28775251997081 no 2408 0.269760977761606 3558 2980565
SGTC_1485 3909-9022 254 µM -0.613792481599231 0.287664894200082 no 2409 0.269676233058203 3555 714516
SGTC_1218 1348-1416 30.7 µM -0.616164398005993 0.286854989642297 no 2410 0.268893011514474 3535 6787668
SGTC_2939 9044578 71.43 µM -0.616661679636167 0.286685327079487 no 2411 0.268728950980535 3522 2653634
SGTC_2589 lobaric acid 100 µM -0.618097375993222 0.286195763322741 no 2412 0.268255575950488 3494 73157 A novel microtubule depolymerizer.
SGTC_319 1348-1596 45.5 µM -0.620397744194604 0.285412180521284 no 2413 0.26749797860564 3595 5380505
SGTC_3284 9108171 64.8615 µM -0.621089762140018 0.285176655983854 no 2414 0.267270282484277 3498 8687505
SGTC_2304 7443016 91.4 µM -0.621322089222008 0.28509760550089 no 2415 0.267193861350403 3524 939854
SGTC_1685 st024049 53.0905 µM -0.621622542493287 0.284995390224383 no 2416 0.267095047302149 3539 1941139
SGTC_3332 9141069 11.198 µM -0.621944900367181 0.284885742360958 no 2417 0.266989049717872 3524 17332883
SGTC_2092 5303694 80.6725 µM -0.622135861148268 0.284820797828346 no 2418 0.266926268093786 3518 1963699
SGTC_198 3454-2873 16.191 µM -0.622176910301216 0.284806838198164 no 2419 0.266912773456295 3502 710957
SGTC_1510 1123-0200 71.5 µM -0.623484652312932 0.284362283911885 no 2420 0.266483042381356 3650 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2248 tofa 1.1 µM -0.623597066119233 0.284324085405174 no 2421 0.266446118939621 3510 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1280 0880-0253 10.1 µM -0.624929970137475 0.283871348154846 no 2422 0.266008510619128 3520 6836607
SGTC_3113 9123498 49.47 µM -0.625725615690012 0.283601261923581 no 2423 0.265747464308392 3595 8897275
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.626215535399123 0.283435017266143 no 2424 0.265586789355397 3513 4620898
SGTC_10 0279-0212 42.575 µM -0.629571397530231 0.282297528873265 no 2425 0.264487521044701 3564 39851 YBR002C RER2
SGTC_2830 7992007 71.43 µM -0.63003968135501 0.282138976237344 no 2426 0.264334311198142 3509 1952075
SGTC_1697 st025554 27.742 µM -0.63096163536725 0.281826944231915 no 2427 0.264032804796251 3552 1269519
SGTC_3326 9140064 16.379 µM -0.631176404340201 0.281754280338427 no 2428 0.263962594124572 3547 1868434
SGTC_2754 granisetron 64.02 µM -0.63123266943919 0.281735245370465 no 2429 0.263944201930956 3579 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2584 androsterone 48.74 µM -0.631953599476157 0.281491403399752 no 2430 0.263708598831683 3628 2754130 A steroid.
SGTC_1312 1218-2183 165 µM -0.632628044758197 0.281263376305093 no 2431 0.263488284311592 3587 6744073
SGTC_1204 4049-0315 18.3 µM -0.63288822202795 0.281175435315343 no 2432 0.263403319835326 3610 588402
SGTC_2720 fluspirilene 36.88 µM -0.63317881918488 0.281077227979687 no 2433 0.263308437863892 3547 3396 An atypical antipsychotic.
SGTC_804 1595-0054 20.9 µM -0.633694085428126 0.280903134457256 no 2434 0.26314024281103 3539 761523 Stimulates phospholipase C.
SGTC_2715 st079500 56.4 µM -0.633776208709636 0.280875392198142 no 2435 0.263113440907838 3546 28246688
SGTC_2995 9067767 71.4286 µM -0.633884838383753 0.280838697786979 no 2436 0.263077990473228 3528 11673567
SGTC_2229 7354935 190 µM -0.635602853491809 0.28025867163738 no 2437 0.262517654579093 3529 318112
SGTC_1995 st072814 61.1 µM -0.636198236984229 0.280057797247457 no 2438 0.262323611065791 3506 5769371
SGTC_628 1636-0253 16 µM -0.63632887935047 0.280013729606913 no 2439 0.262281042786011 3549 4456143
SGTC_1407 3909-7909 12.3 µM -0.636847538058613 0.279838811373523 no 2440 0.262112078856355 3593 4411780
SGTC_3178 9107506 49.47 µM -0.638265740500846 0.279360791780923 no 2441 0.261650354701272 3608 8897194
SGTC_131 0141-0277 33.849 µM -0.63893865413235 0.279134118229199 no 2442 0.261431420319076 3559 1547771
SGTC_204 PMA1.184 62.41 µM -0.639342860929224 0.27899800261197 no 2443 0.261299955717052 3597 2252213 YGL008C PMA1
SGTC_1605 st000082 49.1 µM -0.640354708582444 0.278657407099142 no 2444 0.260971010406987 3570 1114022
SGTC_1951 sophoraflavanone G 9.2 µM -0.64122397823759 0.278364966178199 no 2445 0.260688586448976 3574 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1133 3473-0247 50 µM -0.641293316090231 0.278341645883274 no 2446 0.260666065496171 3519 711311
SGTC_251 melphalan 456.522 µM -0.64150981507121 0.278268837238141 no 2447 0.260595753015175 3628 460612 A DNA alkylator.
SGTC_1441 4106-0040 13 µM -0.641777892931476 0.278178695475673 no 2448 0.260508702767707 3584 2904180
SGTC_175 3793-3120 23.7 µM -0.641918680473293 0.278131361062843 no 2449 0.260462992231946 3563 5322297
SGTC_738 1315-0003 72.4 µM -0.641973747706056 0.278112847886076 no 2450 0.260445114268744 3597 6251474
SGTC_413 propylparaben 100 µM -0.642680528423 0.277875287069239 no 2451 0.260215709076995 3546 7175 A pharmaceutical preservative.
SGTC_2655 perillic acid 100 µM -0.643799534731801 0.277499373022509 no 2452 0.259852717760207 3551 5702197 An apoptosis inducer.
SGTC_2305 7443522 69.23 µM -0.643932275744686 0.277454797087574 no 2453 0.259809675614316 3558 5415886
SGTC_3057 9095946 49.47 µM -0.64598094965488 0.276767273407184 no 2454 0.259145846446976 3604 24540043
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.647076002265252 0.276400122377871 no 2455 0.258791377909677 3573 115019
SGTC_1369 1866-0067 208 µM -0.650442927076803 0.275272752951046 no 2456 0.257703078198104 3623 3531355
SGTC_995 3931-2021 34.6 µM -0.650581744744579 0.275226320352144 no 2457 0.25765825886243 3572 730143
SGTC_2646 retinol 96.75 µM -0.651258091787691 0.275000146749993 no 2458 0.257439948134042 3612 445354 A vitamin A analog and teratogen.
SGTC_2214 7179297 48.276 µM -0.651277486855197 0.274993662299837 no 2459 0.257433689228216 3609 769744
SGTC_1247 0448-0043 5.84 µM -0.653601045979896 0.27421736067389 no 2460 0.256684435086489 3618 3089013 YGL099W LSG1
SGTC_635 k038-0028 24.7 µM -0.654078307142336 0.274058041701035 no 2461 0.256530678283705 3604 4035102
SGTC_2895 9054447 58.44 µM -0.655343868953994 0.273635794353868 no 2462 0.256123191073285 3625 2697450
SGTC_1042 0350-0096 82 µM -0.655361546851278 0.273629898506414 no 2463 0.256117501512815 3599 3122515
SGTC_1356 1502-0781 85.8 µM -0.655815839924164 0.273478406427226 no 2464 0.255971311721327 3575 567702
SGTC_2744 captopril 92.04 µM -0.656344517773928 0.27330216171369 no 2465 0.255801240019034 3577 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_94 0334-0113 514.748 µM -0.656412483115298 0.273279508269352 no 2466 0.255779380357741 3554 6795178
SGTC_665 3914-0008 307 µM -0.657256851846159 0.272998150344472 no 2467 0.255507887768388 3581 1069549
SGTC_708 3448-5400 146 µM -0.663172693521732 0.271030929067331 no 2468 0.253609978958671 3606 3462195
SGTC_2905 7799065 20.05 µM -0.663275456419329 0.270996819445543 no 2469 0.253577076323554 3560 1296806
SGTC_162 k030-0015 37.8 µM -0.664184751703105 0.270695094535308 no 2470 0.253286035801632 3660 1809920 YMR134W ERG29
SGTC_3030 9087619 49.47 µM -0.665939298676836 0.270113370361059 no 2471 0.252724950125333 3588 25236973
SGTC_654 1124-0271 80.9 µM -0.667183033909231 0.269701386128385 no 2472 0.25232761345726 3626 5403748
SGTC_2159 5658611 73.75 µM -0.667979097917151 0.269437857180786 no 2473 0.252073467482188 3644 793844
SGTC_901 1112-0062 60.1 µM -0.668416806234412 0.269293013282641 no 2474 0.251933785266158 3631 1908457
SGTC_2071 5230951 39.92 µM -0.670709524225593 0.268534958876743 no 2475 0.251202797138559 3670 1799272
SGTC_62 0180-0423 3.232 µM -0.671906795426715 0.268139525052143 no 2476 0.250821517006957 3605 30102 YGL099W LSG1
SGTC_805 3852-0218 479 µM -0.672254908180478 0.26802460565218 no 2477 0.250710715368612 3603 6615355
SGTC_3221 9128209 49.47 µM -0.67299249501211 0.267781194559956 no 2478 0.250476032771291 3656 16460723
SGTC_1400 3771-8998 51.5 µM -0.677600142869408 0.266263149715944 no 2479 0.249012627749544 3590 670767
SGTC_2596 sinensetin 100 µM -0.680208329880627 0.265405786077606 no 2480 0.248186279362945 3636 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1104 tacrolimus 29.8 µM -0.682699772402267 0.264588109048292 no 2481 0.247398286790463 3692 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2134 5324836 1.464 µM -0.683269048535098 0.264401455939525 no 2482 0.247218424191827 3612 699272
SGTC_497 capsazepine 133 µM -0.683481365434407 0.264331859067058 no 2483 0.247151360647303 3632 2733484 A calcium channel blocker.
SGTC_1389 3405-0187 19 µM -0.684789967599244 0.263903109011032 no 2484 0.246738233494964 3599 799890
SGTC_2445 5742597 35.57 µM -0.685097915957175 0.263802264448389 no 2485 0.246641067630333 3620 1774255
SGTC_1658 st012944 20 µM -0.685205485484795 0.263767043037153 no 2486 0.246607131425044 3596 24207260
SGTC_2415 st077333 57.7 µM -0.685674489137892 0.263613505543527 no 2487 0.246459198637652 3691 2766255
SGTC_2824 7998404 51.95 µM -0.688676083905545 0.262631955881813 no 2488 0.24551356487872 3634 837851
SGTC_96 0929-0093 37.281 µM -0.689702754224228 0.262296654791709 no 2489 0.245190566740069 3627 6991579
SGTC_888 0916-0002 6.97 µM -0.689989273564791 0.262203119357951 no 2490 0.245100466417587 3701 2802138 YIL048W NEO1
SGTC_2841 9004761 38.96 µM -0.691606248633287 0.261675571653588 no 2491 0.244592318247953 3585 2991039
SGTC_541 4513-1321 94 µM -0.692033010366312 0.261536429008326 no 2492 0.244458299443993 3649 747515
SGTC_2643 anethole 100 µM -0.692581719355911 0.261357582151739 no 2493 0.244286042892507 3660 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1157 4092-0394 27.6 µM -0.693121378747407 0.261181746224086 no 2494 0.244116691126047 3751 3659885
SGTC_1865 st057639 52.2 µM -0.693323122908977 0.261116028021746 no 2495 0.244053397584847 3661 688818
SGTC_1581 himbacine 57.9 µM -0.694416171031683 0.260760115201559 no 2496 0.243710627672431 3667 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2889 9059656 51.95 µM -0.694874454693637 0.260610965487721 no 2497 0.243566991467464 3728 3949838
SGTC_1273 0849-0096 14.1 µM -0.694875723134238 0.260610552731091 no 2498 0.243566593973669 3675 5286025
SGTC_3107 9121808 49.47 µM -0.69605947798494 0.260225499997568 no 2499 0.243195791098668 3613 662681
SGTC_2138 5575593 77.673 µM -0.697170128051143 0.25986449361916 no 2500 0.242848165471551 3667 762213
SGTC_552 k242-0005 476 µM -0.698147045652622 0.259547169432505 no 2501 0.242542619574044 3700 4088318
SGTC_340 k038-0059 454 µM -0.698162270749823 0.259542225572135 no 2502 0.242537859340641 3671 23733424
SGTC_2437 5741531 144.16 µM -0.699825637456361 0.259002393772884 no 2503 0.242018100935648 3714 2262990
SGTC_1893 st059353 36.1 µM -0.699860466929796 0.25899109636788 no 2504 0.242007224100804 3679 3112488
SGTC_3022 9087993 49.47 µM -0.70066628922888 0.258729788320091 no 2505 0.241755649316291 3702 17173644
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.701136347392445 0.25857742323922 no 2506 0.241608964442149 3633 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_3255 9139072 49.47 µM -0.701804148566272 0.25836104148038 no 2507 0.241400655622551 3691 17646060
SGTC_2693 st077581 40.7 µM -0.701947570358278 0.258314582016583 no 2508 0.241355930449952 3712 25238761
SGTC_269 exalamide 29 µM -0.704212441395131 0.257581483473118 no 2509 0.24065024209934 3657 3316 A derivative of salicylamide.
SGTC_1287 0971-0001 34.6 µM -0.704433748165714 0.257509908391219 no 2510 0.240581347637437 3680 4665869
SGTC_1433 4060-0023 7.6 µM -0.706572431053973 0.25681874782356 no 2511 0.239916113202608 3693 3840627
SGTC_2642 cholecalciferol 100 µM -0.706950519521865 0.256696661056407 no 2512 0.239798613737346 3671 9821465 A vitamin D precursor, similar to steriods.
SGTC_2534 helenine 20.12 µM -0.707998096439211 0.256358550844127 no 2513 0.239473219796402 3705 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_832 4083-0019 164 µM -0.70898913527537 0.256038902331649 no 2514 0.239165609544124 3767 1990758
SGTC_595 3909-8003 73.7 µM -0.710000450222862 0.255712928446582 no 2515 0.23885192849378 3741 699517
SGTC_1773 st048542 73.5835 µM -0.710072476037387 0.255689720866765 no 2516 0.238829596727381 3646 3237138
SGTC_2884 9058502 51.95 µM -0.710195211568319 0.255650176543166 no 2517 0.238791544930254 3676 6471554
SGTC_1822 st052468 42 µM -0.710745776957218 0.255472828454614 no 2518 0.238620893504704 3701 2873678
SGTC_712 r015-0009 80.6 µM -0.713695535823378 0.254523748224738 no 2519 0.237707733732549 3704 6813872 YLR060W FRS1
SGTC_1228 0124-0032 52.5 µM -0.71401565047511 0.254420863066636 no 2520 0.237608750964087 3743 X1228
SGTC_939 1165-0479 45.3 µM -0.715263311963936 0.254020071571904 no 2521 0.237223177050019 3640 1377347
SGTC_2834 9001755 58.44 µM -0.715433619532709 0.253965388668365 no 2522 0.237170572333524 3659 2989575
SGTC_282 k297-0036 65.7 µM -0.715455101904182 0.253958491477987 no 2523 0.237163937299356 3706 5061378
SGTC_1762 st045503 25.4615 µM -0.71549755198803 0.253944862624149 no 2524 0.237150826488218 3760 4645554
SGTC_2456 5770359 74.46 µM -0.715655298900743 0.253894220395828 no 2525 0.237102109461849 3694 3118787
SGTC_3254 9136651 49.47 µM -0.717874111590426 0.253182466585976 no 2526 0.236417455837124 3703 16454030
SGTC_2325 6158266 200 µM -0.718444461468071 0.25299967864446 no 2527 0.236241640350657 3737 3623240
SGTC_706 4262-0057 46.9 µM -0.718761606932218 0.252898068684431 no 2528 0.236143908564518 3691 883298
SGTC_2978 9011784 42.97 µM -0.719946628501729 0.25251859080274 no 2529 0.235778928577954 3763 2994934
SGTC_3325 9138760 55.175 µM -0.72041744817442 0.252367904168038 no 2530 0.23563400514732 3706 43844959
SGTC_3099 9120367 49.47 µM -0.720426841060372 0.25236489844127 no 2531 0.235631114414553 3733 24824940
SGTC_1225 1216-0074 20.6 µM -0.720922393401868 0.252206348283444 no 2532 0.235478632119422 3717 4241466
SGTC_1488 4013-0813 75.9 µM -0.721657423605906 0.251971274838059 no 2533 0.235252562391517 3681 2910057
SGTC_1479 0549-0158 134 µM -0.722049424488154 0.251845954494579 no 2534 0.235132045566336 3754 5440202
SGTC_1821 st053465 65.6 µM -0.722360249673111 0.251746608930613 no 2535 0.235036509656177 3680 675086
SGTC_1375 2910-0797 186 µM -0.723158836018436 0.251491460655889 no 2536 0.23479115275944 3731 742508
SGTC_2033 5192550 145 µM -0.724100339812612 0.251190825876728 no 2537 0.234502067998094 3713 182073
SGTC_2576 guaiol 23.12 µM -0.725624807817074 0.250704446131711 no 2538 0.234034404356008 3719 227829
SGTC_2883 9059145 45.46 µM -0.726951638536331 0.250281528636141 no 2539 0.233627791060347 3714 16476510
SGTC_1196 1588-0294 184 µM -0.728952147566504 0.249644596969415 no 2540 0.233015467184547 3729 6144269
SGTC_1529 apigenin 74 µM -0.729193873580887 0.249567693423552 no 2541 0.232941539110287 3762 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_890 0929-0006 47.2 µM -0.729489047538138 0.24947380283593 no 2542 0.232851282498963 3711 1378169
SGTC_2051 5263410 176 µM -0.730406692312189 0.249182033167717 no 2543 0.232570814435324 3774 227584
SGTC_2244 6635614 200 µM -0.731316238296948 0.248893017735193 no 2544 0.232293007118852 3647 836499
SGTC_2864 9034755 47.6 µM -0.731493518194651 0.248836706429997 no 2545 0.232238881114368 3718 4930451
SGTC_1113 artemisinin 1.17947 µM -0.732094526795349 0.248645852139212 no 2546 0.232055437111543 3737 2240 An anti-malaria and mitochondrial poison.
SGTC_1833 st055984 71 µM -0.732455316074 0.2485313185588 no 2547 0.231945353271658 3767 676288
SGTC_1223 0764-0573 147 µM -0.733592130600052 0.248170617461398 no 2548 0.231598679254316 3731 1609797
SGTC_2475 5812728 15.03 µM -0.734258697720081 0.247959251586457 no 2549 0.231395542576697 3722 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_878 0828-0289 13.7 µM -0.734470496390862 0.247892111158472 no 2550 0.231331017628514 3724 745350 YLR208W SEC13
SGTC_1962 st076595 64.5 µM -0.734644316525657 0.247837017221359 no 2551 0.231278070426372 3753 279619
SGTC_289 k017-0060 526 µM -0.734760360588168 0.247800239596163 no 2552 0.231242726107394 3721 5512909
SGTC_2416 tofa 880 nM -0.735207165131928 0.247658661888436 no 2553 0.231106667989237 3751 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_925 2064-1272 59.6 µM -0.735265725035378 0.247640109378073 no 2554 0.231088839006575 3728 6815817
SGTC_693 4161-2696 114 µM -0.735765903310478 0.247481676892194 no 2555 0.230936587425596 3759 805759
SGTC_2920 7982904 15.77 µM -0.737174410016369 0.24703582069266 no 2556 0.230508146600178 3735 6456808
SGTC_613 3914-0030 117 µM -0.738238076876825 0.246699406944441 no 2557 0.230184894112227 3502 1145395
SGTC_1729 st035615 45.989 µM -0.741211026949191 0.245760432702875 no 2558 0.229282749236872 3810 17385451
SGTC_880 0833-0487 87.2 µM -0.741660702950941 0.245618574629323 no 2559 0.229146467379823 3722 76075
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.74237957079863 0.245391886711086 no 2560 0.228928696814478 3785 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_68 0986-0284 82.829 µM -0.742520950126079 0.245347317362758 no 2561 0.228885881672888 3799 423278 YIL048W NEO1
SGTC_1758 st042942 75.2445 µM -0.742617516790872 0.245316877553708 no 2562 0.228856640126191 3693 669317
SGTC_1214 0358-0031 63.7 µM -0.744115488936972 0.244844945864073 no 2563 0.228403304786419 3840 4301366
SGTC_2733 amorolfine 100 µM -0.744877674361725 0.244605009299496 no 2564 0.228172836390601 3773 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1156 4092-0367 4.88 µM -0.745375376050829 0.244448400789923 no 2565 0.228022412751717 3776 1357585
SGTC_63 0099-0242 26.702 µM -0.745583359938215 0.244382971880058 no 2566 0.227959568948477 3797 3898502 YLR359W ADE13
SGTC_61 0978-8327 98.565 µM -0.748358348215863 0.243510901879086 no 2567 0.227122019421662 3739 6150059 YHR072W ERG7
SGTC_590 k048-0076 22.4 µM -0.749137443235546 0.243266365434878 no 2568 0.226887184509714 3740 6832814
SGTC_268 camptothecin 39.6153 µM -0.749181200938469 0.243252635036465 no 2569 0.226873999121198 3745 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2480 5767542 37.17 µM -0.750603477840779 0.242806577705988 no 2570 0.226445663740564 3751 2867358
SGTC_1864 st057645 30.4 µM -0.751134488321878 0.242640154694289 no 2571 0.226285860852485 3779 688666
SGTC_3286 9117135 37.221 µM -0.751392469282237 0.242559323656241 no 2572 0.226208246773307 3748 3438150
SGTC_640 3381-0960 37.1 µM -0.752897030367716 0.242088202647641 no 2573 0.225755896391473 3790 1745025
SGTC_1940 st075990 51.1 µM -0.756336903771508 0.241012946688289 no 2574 0.224723613715366 3840 1084979
SGTC_2922 7999257 32.47 µM -0.756385581150796 0.240997749484043 no 2575 0.22470902519806 3736 2988377
SGTC_2455 5377712 9.75 µM -0.756836397934066 0.240857028079109 no 2576 0.224573941796115 3763 2243908
SGTC_576 1073-0113 22.7 µM -0.757599422451751 0.240618953654718 no 2577 0.224345413019666 3913 5439563
SGTC_2698 st077697 67.5 µM -0.75936798874405 0.240067628917375 no 2578 0.223816228521632 3756 3154499
SGTC_3169 9102970 49.47 µM -0.759810285693276 0.239929857028917 no 2579 0.223683996896328 3835 17027839
SGTC_765 1319-0117 244 µM -0.760669923743445 0.239662210188014 no 2580 0.223427121693679 3735 3487746 YGL099W LSG1
SGTC_285 1486-1325 46 µM -0.761137904849668 0.239516573596858 no 2581 0.223287351164111 3770 22310230
SGTC_2478 5763493 32.33 µM -0.762039369887779 0.239236172234591 no 2582 0.22301825357832 3738 1365576 YLR208W SEC13
SGTC_1354 1498-1681 81 µM -0.762607083294014 0.239059676649255 no 2583 0.222848879485569 3829 5754243
SGTC_3192 9110362 49.47 µM -0.763490591923891 0.23878514558874 no 2584 0.222585435504857 3813 16649480
SGTC_2243 6634756 200 µM -0.766150733938127 0.237959606733549 no 2585 0.221793309235307 3804 885676
SGTC_2761 levamisole 97.89 µM -0.768501470653123 0.237231391843989 no 2586 0.22109465864096 3758 26879 An alkaline phosphatase inhibitor.
SGTC_2429 5902844 64.44 µM -0.768650858442929 0.237185155664322 no 2587 0.221050302447562 3822 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.770043175788378 0.236754465473371 no 2588 0.220637140843141 3814 4174840
SGTC_2531 methyl deoxycholate 70.07 µM -0.770595197420534 0.236583825916906 no 2589 0.220473454366359 3765 16667744 Haematoxylin.
SGTC_2695 st077686 51.995 µM -0.770672066631332 0.236560069666074 no 2590 0.220450666487037 3840 2876092
SGTC_2723 salbutamol 83.58 µM -0.773665648707704 0.235635931720966 no 2591 0.21956426950447 3755 9884233 β2-adrenoceptor agonist
SGTC_2205 7238770 200 µM -0.774243196427275 0.235457868474112 no 2592 0.219393494008066 3823 279867
SGTC_2406 ethylparaben 405.7 µM -0.777966316304203 0.234311780589913 no 2593 0.218294435475244 3849 8434 A possible steroid mimic.
SGTC_2165 5727197 32.143 µM -0.779207492071021 0.233930396848868 no 2594 0.217928748734896 3892 1361712
SGTC_1564 D-Arginine 115 µM -0.780290939668047 0.233597760554255 no 2595 0.217609822294102 3793 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1597 7-benzyloxygramine 47.5 µM -0.781210777748198 0.233315561063065 no 2596 0.217339267902506 3777 260807
SGTC_2930 9013230 14.89 µM -0.781211652376985 0.233315292823504 no 2597 0.217339010738114 3818 2995857
SGTC_825 1988-2224 89.6 µM -0.785936296735524 0.231868793305454 no 2598 0.215952404354859 3798 1180859
SGTC_2404 5161160 200 µM -0.786370652432082 0.23173606192033 no 2599 0.215825185789194 3772 2831543
SGTC_205 1486-1330 71.903 µM -0.78858817452543 0.231059086744692 no 2600 0.21517637239124 3788 4118834
SGTC_838 0109-0203 71.4 µM -0.788644561952643 0.231041886938619 no 2601 0.215159889057559 3819 759422
SGTC_2053 5265679 138 µM -0.789197796065386 0.23087317234286 no 2602 0.214998204960888 3779 764595
SGTC_1608 st001473 40.5 µM -0.789802190194 0.230688934617628 no 2603 0.21482164988764 3786 7292267
SGTC_481 bay k-8644 50 µM -0.790584513685339 0.230450580620405 no 2604 0.214593243369124 3791 2303 A calcium channel antagonist.
SGTC_23 0213-0011 39.996 µM -0.79176608302708 0.230090847724004 no 2605 0.214248541101116 3828 627608
SGTC_2731 amoxapine 43.43 µM -0.791962794572252 0.230030988732546 no 2606 0.214191185228411 3870 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.792023455637426 0.230012531430868 no 2607 0.21417349987204 3861 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1470 k295-0292 231 µM -0.792151785792151 0.229973487232057 no 2608 0.214136088813484 3871 5045612
SGTC_387 norethindrone acetate 66.7 µM -0.792687636418528 0.229810495814014 no 2609 0.213979917681924 3824 541197
SGTC_2612 dictamnine 15.46 µM -0.792997268048187 0.22971634365292 no 2610 0.213889707239705 3814 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_3304 9125678 46.087 µM -0.793081696962559 0.22969067442795 no 2611 0.213865112918117 3793 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_3204 9114183 49.47 µM -0.794013738762906 0.229407409206759 no 2612 0.213593716614677 3842 17027248
SGTC_2184 6075246 200 µM -0.794141102229788 0.229368716239745 no 2613 0.213556645913404 3871 2267320
SGTC_2674 ligustilide 100 µM -0.794565763015374 0.229239730910359 no 2614 0.213433070268892 3851 5319022 A signalling regulator.
SGTC_979 1426-2828 121 µM -0.796687620780931 0.228595853196495 no 2615 0.212816237609876 3944 747872
SGTC_3124 9127567 49.47 µM -0.798035766491272 0.22818728665509 no 2616 0.212424867383181 3760 17592030
SGTC_758 0868-0029 16 µM -0.79902368771664 0.227888149919574 no 2617 0.212138338440482 3897 762687
SGTC_2028 5153890 36.43 µM -0.799273660949373 0.227812494487215 no 2618 0.212065873996983 3796 2830968 YPR165W RHO1
SGTC_1625 st003711 30.1 µM -0.802617133032892 0.226801938699995 no 2619 0.211098031245449 3857 24207034 YER133W GLC7
SGTC_76 0433-0009 400.328 µM -0.80354866033445 0.226520838115887 no 2620 0.210828841667172 3931 2841569
SGTC_922 1866-0035 480 µM -0.803728097141039 0.226466713308266 no 2621 0.210777011765352 3798 3156169
SGTC_3322 9139058 2.11 µM -0.805896210736384 0.225813307157995 no 2622 0.210151348160766 3956 4908926 YPR165W RHO1
SGTC_288 1315-0019 35.1 µM -0.80612704333773 0.225743803808153 no 2623 0.210084799935761 3914 6811474
SGTC_1253 0550-0034 176 µM -0.80729960857174 0.225390933097959 no 2624 0.209746944740565 3864 5969915
SGTC_1820 st053765 18.6 µM -0.808158288560724 0.225132720936111 no 2625 0.20949973311771 3859 3690829
SGTC_3005 9076496 71.4286 µM -0.809647972476647 0.224685158499408 no 2626 0.209071264054729 3846 21368410
SGTC_1472 k841-0093 193 µM -0.80971695417716 0.22466444578621 no 2627 0.209051435761266 3942 X1472
SGTC_421 streptovitacin 30 mM -0.80998089212489 0.224585204753641 no 2628 0.208975578923089 3945 91467 include heat shock
SGTC_250 brefeldin a 552.239 µM -0.810432683133433 0.224449602155506 no 2629 0.208845769987003 3722 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1380 2291-0730 164 µM -0.810625057080656 0.224391876275885 no 2630 0.208790511382756 3887 2999191
SGTC_707 0865-0008 204 µM -0.810813019946621 0.224335482174553 no 2631 0.208736528165406 3844 723043
SGTC_1053 3366-3204 134 µM -0.811755418086896 0.224052857773988 no 2632 0.208465994038772 3869 3632071 YPR165W RHO1
SGTC_1401 3807-4679 7.6 µM -0.811915772504973 0.224004787764593 no 2633 0.20841998170767 3793 3291456
SGTC_2403 6032726 181.2 µM -0.812148213720843 0.223935118445092 no 2634 0.208353295320266 3915 2881040
SGTC_2157 5649910 96.377 µM -0.812583104089538 0.223804802364278 no 2635 0.20822856094785 3815 2858091
SGTC_652 0437-0092 114 µM -0.812753014660081 0.223753899913033 no 2636 0.208179839515528 3806 3091274
SGTC_452 diindolylmethane 8 µM -0.813400527404577 0.223559975939914 no 2637 0.207994228527919 3853 3071 Inhibits expression of several cancer promoting factors.
SGTC_2854 9024559 71.43 µM -0.81531584226986 0.22298691706826 no 2638 0.207445771409287 3900 3163529
SGTC_2519 cryptotanshinone 88.04 µM -0.816296981660594 0.222693686238121 no 2639 0.207165150146092 3805 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2011 4012611 177 µM -0.817275694954062 0.222401399581948 no 2640 0.206885446612004 3876 2049887
SGTC_1084 voriconazole 435 nM -0.817406273136836 0.222362419768569 no 2641 0.206848145972419 3844 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1147 3809-1045 12.3 µM -0.817511896400411 0.222330892275306 no 2642 0.206817976805647 3831 325925
SGTC_3140 9094243 49.47 µM -0.818240010052669 0.222113626987238 no 2643 0.206610076622916 3870 19291112
SGTC_598 3937-0236 20.2 µM -0.819430790972945 0.221758565510283 no 2644 0.206270336715334 3922 1379313
SGTC_1943 st076331 65.2 µM -0.819838860384501 0.221636963924153 no 2645 0.206153987269469 3887 24208415
SGTC_1675 st018485 24.5 µM -0.820991491895789 0.221293694383799 no 2646 0.205825557246282 3922 3323024
SGTC_2822 7994718 71.43 µM -0.822088882898418 0.220967158973918 no 2647 0.205513156084605 3835 1018011
SGTC_1610 st001799 48.1 µM -0.823968835351416 0.220408409035578 no 2648 0.204978632992696 3772 621897
SGTC_1250 0485-0349 40.2 µM -0.825326330082805 0.220005445344793 no 2649 0.204593173621456 3883 6842794 YDL195W SEC31
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.827052845518169 0.219493551374301 no 2650 0.204103554753998 3908 5282362
SGTC_2846 9008642 19.48 µM -0.827914103999973 0.219238453139352 no 2651 0.203859573431048 3946 2992898
SGTC_2565 isoliquiritigenin 100 µM -0.829586236822392 0.218743667002459 no 2652 0.20338638047909 3961 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1660 st012960 28.1 µM -0.831004834987113 0.218324406404133 no 2653 0.202985448992101 3882 24207266
SGTC_857 0438-0306 1.35 µM -0.831648099711924 0.218134444932517 no 2654 0.202803801862636 3953 4686136
SGTC_2521 angolensin 13.4 µM -0.831837808953292 0.218078440396462 no 2655 0.202750249715782 3957 821428 A flavenoid.
SGTC_3046 9092212 49.47 µM -0.832195980037293 0.217972726421003 no 2656 0.202649166290447 3909 25236637
SGTC_1722 st034304 3.6505 µM -0.834017456061325 0.217435576297591 no 2657 0.2021355736226 3896 4036148 YLR033W RSC58
SGTC_1393 3470-5649 58.2 µM -0.834997731528278 0.217146811353148 no 2658 0.201859492812388 3857 4108395
SGTC_1391 3442-0225 151 µM -0.8358106926307 0.216907501236568 no 2659 0.201630705083955 3834 5227075
SGTC_103 0844-0104 51.839 µM -0.838383780312406 0.216151070997238 no 2660 0.200907597956526 3866 5375804
SGTC_2197 6588183 93.1375 µM -0.83959955550746 0.2157941923703 no 2661 0.200566474275631 3824 884136
SGTC_662 k832-1615 104 µM -0.840071314984912 0.215655804126423 no 2662 0.200434201144642 3933 5878478
SGTC_1607 st000305 50.6 µM -0.840475942557611 0.215537149689411 no 2663 0.200320792383207 3893 5457690
SGTC_438 sphingosine 6.67 µM -0.840669857704958 0.215480298741062 no 2664 0.200266455635864 3858 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2601 securinine 100 µM -0.84069746237422 0.215472206467217 no 2665 0.200258721282412 3846 442872 A GABA receptor antagonist.
SGTC_1505 k297-0037 20.6 µM -0.841145324509778 0.215340940881482 no 2666 0.200133263096722 3893 4089396
SGTC_944 3370-0224 231 µM -0.841868265144736 0.215129149439877 no 2667 0.199930847756322 3932 4580514
SGTC_3263 9137018 49.47 µM -0.842316444267738 0.214997912398994 no 2668 0.199805424423498 3912 43844957
SGTC_1458 k015-0034 6.33 µM -0.842375773438367 0.21498054295366 no 2669 0.199788824649438 3923 3598957
SGTC_1787 fluconazole 80 µM -0.842720178395432 0.2148797296777 no 2670 0.199692479592989 3730 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3179 9107801 49.47 µM -0.842965694609315 0.214807879612589 no 2671 0.199623815091518 3880 4818259
SGTC_2458 5808907 16.39 µM -0.84434169970056 0.214405451558172 no 2672 0.199239245262567 4002 2731747
SGTC_2624 nerol 100 µM -0.845595716774158 0.214039082401393 no 2673 0.198889157901805 3814 637566 A natural product oil.
SGTC_2968 9090663 33.37 µM -0.846484330617214 0.21377968887897 no 2674 0.198641305760122 3884 25236811
SGTC_1612 st002233 45.4 µM -0.847443967587178 0.213499768855929 no 2675 0.19837385315389 3889 1035021
SGTC_803 4488-1585 147 µM -0.847743840663091 0.213412341602223 no 2676 0.198290322551748 3917 747204
SGTC_1527 coumarin 137 µM -0.850399554897558 0.212638985948214 no 2677 0.197551491761738 4020 323 A hepatotoxic, DNA x-linker.
SGTC_1928 4'-methoxychalcone 40.3 µM -0.85191488981321 0.212198448058057 no 2678 0.197130665995208 3958 641818
SGTC_1311 1190-0148 100 µM -0.852005443269998 0.212172139278795 no 2679 0.19710553545713 3958 1961333
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.852259260927384 0.212098407004392 no 2680 0.197035105914257 3922 1377
SGTC_1530 rhein 70.4 µM -0.853023821364233 0.211876398039743 no 2681 0.196823047083948 3957 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1404 3909-7820 48.3 µM -0.85483753203937 0.211350286544531 no 2682 0.196320548535227 3849 23741373
SGTC_2623 humulene 100 µM -0.85822597271692 0.210369438597729 no 2683 0.195383848464815 3901 6187145 An anti-inflammatory.
SGTC_3335 9143315 29.6265 µM -0.858828049555764 0.210195436160784 no 2684 0.195217694937407 3914 4899691
SGTC_3273 9137859 49.47 µM -0.859401603536719 0.210029755580717 no 2685 0.195059492671511 3977 2377234
SGTC_2321 7390090 138.78 µM -0.859413756309046 0.210026245881215 no 2686 0.195056141439625 3949 649046
SGTC_852 0418-0143 439 µM -0.864177322067249 0.208653192255248 no 2687 0.193745244034839 3960 5369229
SGTC_2177 5811945 192 µM -0.866005523743944 0.208127638310728 no 2688 0.193243566316035 3968 5343475
SGTC_154 3389-1638 511.116 µM -0.866726967542267 0.207920459709959 no 2689 0.193045812934774 3927 5238686
SGTC_2066 5222451 176 µM -0.866941792585147 0.207858791467099 no 2690 0.192986951595983 3897 2281147
SGTC_703 3875-0075 71.8 µM -0.869947184243746 0.206997188958026 no 2691 0.192164634046517 3956 2850814
SGTC_1050 3232-1156 69.3 µM -0.872022106544285 0.20640357372114 no 2692 0.191598158856856 3919 700529
SGTC_5 0352-0601 109.883 µM -0.874785806385102 0.205614474382673 no 2693 0.190845230756654 3860 762456
SGTC_381 3461-2219 42.7 µM -0.874928500088559 0.205573780752467 no 2694 0.190806405369277 3928 2883159
SGTC_1195 1502-0147 41.1 µM -0.875488490196357 0.205414128038534 no 2695 0.19065408505601 3915 817940
SGTC_3053 9095903 49.47 µM -0.875853710688945 0.205310043664087 no 2696 0.190554783346362 4031 17174018
SGTC_1467 k284-1082 293 µM -0.876733697082058 0.205059384611985 no 2697 0.190315649702126 3886 3334705
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.877782615455338 0.204760844001793 no 2698 0.190030850234174 3930 641818 YHR062C RPP1
SGTC_3137 9097352 49.47 µM -0.878022418467992 0.204692628172169 no 2699 0.189965776379066 3958 44120435
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.880626190875019 0.203952813859903 no 2700 0.189260088964023 3969 368090
SGTC_2292 7671323 168.05 µM -0.881194512082811 0.203791547874589 no 2701 0.189106274560194 3996 937504
SGTC_1213 1315-0166 115 µM -0.881485668155846 0.203708959311492 no 2702 0.189027503888133 4039 768401
SGTC_1384 3089-0840 101 µM -0.882559580370163 0.203404508794031 no 2703 0.188737137644325 3917 1069836
SGTC_724 3910-0327 137 µM -0.883483210289656 0.203142880075378 no 2704 0.188487625013603 3997 2885483
SGTC_1286 0929-0070 131 µM -0.88353570513772 0.203128016346296 no 2705 0.188473449982859 4043 1420408
SGTC_1587 estradiol valerate 56.1 µM -0.884043873103749 0.20298416396515 no 2706 0.188336264856154 3998 13791 A steroid.
SGTC_2195 6536160 144.242 µM -0.886723683279401 0.202226569200313 no 2707 0.187613842155313 3876 3834386
SGTC_1819 st053448 58.6 µM -0.887312481303927 0.202060340205786 no 2708 0.187455343812649 3869 2857616
SGTC_3055 9094636 49.47 µM -0.88765436975474 0.201963856064428 no 2709 0.187363348965419 3950 25236176
SGTC_557 1315-0110 16.2 µM -0.888074366590557 0.201845366756206 no 2710 0.187250375036497 3930 6833801
SGTC_2020 4017018 200 µM -0.892174925933839 0.200690707315059 no 2711 0.186149589809407 4053 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_125 0133-0007 11.75 µM -0.892292844218805 0.200657561954671 no 2712 0.186117994372828 4036 26541
SGTC_393 acivicin 6.25 µM -0.893710538272758 0.200259323152939 no 2713 0.185738392741388 3817 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2198 6589944 200 µM -0.896526701805774 0.199469655914563 no 2714 0.184985762908199 3961 5290268
SGTC_231 b-estradiol 524 µM -0.896859476663036 0.199376468064764 no 2715 0.184896952986487 3925 450 A steroid.
SGTC_1268 0828-0275 2.46 µM -0.897049120956811 0.199323373183907 no 2716 0.184846353160418 4020 745337
SGTC_1681 tripelennamine 100 µM -0.897731201176231 0.199132480971556 no 2717 0.184664435496776 3933 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_368 fentichlor 4.58 µM -0.897845160792906 0.199100598098146 no 2718 0.184634052175863 4028 7329 A pesticide.
SGTC_1635 st007035 42.4 µM -0.900316215511916 0.198410019210449 no 2719 0.183975997036424 3948 3716403
SGTC_2128 5255449 168.493 µM -0.900476375446231 0.198365309681706 no 2720 0.183933396040667 3962 736008
SGTC_2564 betulinic acid 100 µM -0.900919053762417 0.198241765217588 no 2721 0.183815679841425 4035 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1847 st056231 15 µM -0.902012441679336 0.19793681716639 no 2722 0.183525129298893 3951 5393180
SGTC_360 0957-0399 1.01 µM -0.903815785788049 0.197434480399105 no 2723 0.183046544912336 3993 6752301 YPR165W RHO1
SGTC_1678 st019265 80.2 µM -0.904623442886407 0.197209750851462 no 2724 0.182832455767789 3996 5367020
SGTC_1130 3454-2858 15.9 µM -0.905081240653206 0.197082437962385 no 2725 0.182711174774198 4021 715628 YIL048W NEO1
SGTC_1669 st015249 58.4 µM -0.905424476762634 0.196987017136702 no 2726 0.182620276712924 4053 722793
SGTC_904 1141-0088 396 µM -0.905897457963871 0.196855572555341 no 2727 0.182495064974051 3994 1378119
SGTC_1774 st048371 48.465 µM -0.9067748231444 0.196611887677732 no 2728 0.182262943190197 3943 4242727
SGTC_1489 4065-0444 182 µM -0.908247114588832 0.19620337512917 no 2729 0.18187383841848 3939 2877968
SGTC_1046 2001-0062 216 µM -0.910873276962867 0.195475980255841 no 2730 0.18118107370104 3891 739778
SGTC_2461 5755302 26.15 µM -0.911420234812776 0.195324690118525 no 2731 0.181036997980003 4041 2788904
SGTC_766 1391-0721 126 µM -0.912035121805474 0.195154695548217 no 2732 0.180875114586373 4041 1020919 YIL115C NUP159
SGTC_166 k072-0058 166.424 µM -0.91373525401626 0.194685137182442 no 2733 0.180427987411523 3910 5846229
SGTC_3164 9100705 49.47 µM -0.915809367674332 0.194113220850792 no 2734 0.179883444670135 4026 17174235
SGTC_2114 5491910 81.25 µM -0.916945662613426 0.193800333153251 no 2735 0.179585557205983 4049 2849228
SGTC_1929 genistein trimethyl ether 50.5 µM -0.917152009898123 0.193743546816709 no 2736 0.179531495138742 3959 136420
SGTC_2881 9058953 51.95 µM -0.918669811106682 0.193326162944093 no 2737 0.17913415240195 3941 17122249
SGTC_3050 9093513 49.47 µM -0.920702279022508 0.192768109706105 no 2738 0.178602943006491 3968 25236664
SGTC_1094 duloxetine 25.4 µM -0.921235101092604 0.19262197612343 no 2739 0.178463847980165 3987 60834 A selective serotonin reuptake inhibitor.
SGTC_2029 5175081 200 µM -0.921251576701729 0.192617458546571 no 2740 0.178459548053902 3982 1380876
SGTC_1985 st071382 65.5 µM -0.922854572699247 0.192178230158514 no 2741 0.178041498418603 3980 6123237
SGTC_501 nsc-95397 161 µM -0.923181593886975 0.192088700134389 no 2742 0.177956289574015 4056 262093
SGTC_876 0720-0963 56.8 µM -0.923406808101881 0.19202705709421 no 2743 0.177897622573836 4043 765861
SGTC_2471 5466956 24.79 µM -0.924116419578931 0.191832909592555 no 2744 0.177712852666113 3958 724419
SGTC_95 0471-0001 561.058 µM -0.924807096602805 0.191644057950743 no 2745 0.177533129265927 4005 4015405
SGTC_2344 7990960 76.95 µM -0.924887897257273 0.191621972090775 no 2746 0.177512111352682 3983 140813
SGTC_2974 9094440 9.66 µM -0.924959047948395 0.191602525219866 no 2747 0.177493604893988 4058 25236134
SGTC_2142 5622915 118.518 µM -0.925631811587356 0.191418705563742 no 2748 0.177318677724882 4003 5322196
SGTC_377 3970-0964 33.1 µM -0.925833260370215 0.191363684609672 no 2749 0.177266319644828 3966 16481235
SGTC_3184 9108758 49.47 µM -0.927794265307173 0.19082858918744 no 2750 0.176757149663428 4020 902885
SGTC_3276 9139060 49.47 µM -0.932192991878727 0.18963166116196 no 2751 0.17561839830018 4087 4870619
SGTC_897 1000-0139 31.4 µM -0.93457050870603 0.18898664718979 no 2752 0.17500484167241 3952 6151020
SGTC_870 0573-2213 57.6 µM -0.935347683461624 0.188776095199739 no 2753 0.174804574478656 4007 3916321
SGTC_104 0074-0074 590.992 µM -0.937765304697428 0.188122038749997 no 2754 0.174182517447256 3809 3943124
SGTC_1256 0570-0116 285 µM -0.938507757730975 0.187921458633344 no 2755 0.173991766048582 4040 410638
SGTC_760 0568-0725 82.9 µM -0.938646472277543 0.187883998342624 no 2756 0.173956142169774 4049 3916171
SGTC_1197 1601-0112 267 µM -0.938954757375338 0.187800761514805 no 2757 0.173876986757326 3985 7350313
SGTC_491 tetrandrine 80.3 µM -0.939687551773797 0.187602998805929 no 2758 0.173688926107219 4031 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.939825480497031 0.187565789719384 no 2759 0.173653543252767 4016 676296 Flavone; oxidizing agent.
SGTC_1128 3448-9350 235 µM -0.940044788245501 0.187506636371364 no 2760 0.173597293681131 4074 619386
SGTC_3036 9090181 49.47 µM -0.940310926930669 0.187434866914625 no 2761 0.173529048159811 4039 25236586
SGTC_782 0083-0095 30.5 µM -0.941222114525794 0.187189276116543 no 2762 0.173295523089739 3987 3591729 An indicator and reagent.
SGTC_1082 camptothecin 424.86 nM -0.941319856019847 0.187162943845878 no 2763 0.173270485153842 3929 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3256 9138902 49.47 µM -0.942496444237319 0.186846142201826 no 2764 0.172969265373071 4079 17228773
SGTC_2131 toluylene red 5.2905 µM -0.94505325813279 0.186158853613702 no 2765 0.172315843390192 4020 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_953 1188-0045 9.7 µM -0.945477023425179 0.186045094237142 no 2766 0.172207697827854 4057 6144426
SGTC_1469 k284-2957 126 µM -0.94716435647576 0.185592558904516 no 2767 0.171777517488268 3998 23884841
SGTC_2955 9076254 12.21 µM -0.94725506177666 0.185568251501774 no 2768 0.171754411908195 3962 16459619
SGTC_1327 1436-0082 2.18 µM -0.948298917532657 0.185288658987569 no 2769 0.171488650898466 4017 15992205
SGTC_567 1080-0542 68.4 µM -0.948806672927345 0.185152753385239 no 2770 0.171359473700667 3903 5950415
SGTC_988 1497-1057 103 µM -0.94997725187094 0.184839672683546 no 2771 0.171061905739135 3954 3533044
SGTC_2170 morpholine 200 µM -0.951115302825451 0.184535607502193 no 2772 0.170772923642141 4062 121171 Reacts with secondary amines.
SGTC_433 pimozide 108 µM -0.953763793999083 0.183829187210618 no 2773 0.170101610115036 3944 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_49 0717-0965 32.132 µM -0.953932780291445 0.183784171484296 no 2774 0.170058834602981 4112 5889349 YGL099W LSG1
SGTC_1701 st028638 40.4 µM -0.954438300903731 0.183649548440995 no 2775 0.16993091329972 4036 3490878
SGTC_3241 9133421 49.47 µM -0.955269151000903 0.183428421811767 no 2776 0.169720801864186 4048 17018221
SGTC_2026 5148700 152 µM -0.959265756047241 0.182367066246417 no 2777 0.168712440920443 4013 79838
SGTC_676 falcarinol 140 µM -0.959518958396745 0.182299954241403 no 2778 0.168648686814526 4015 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1812 st052057 4.327 µM -0.960724911956057 0.181980524650908 no 2779 0.168345250950996 4062 3645418
SGTC_877 0771-0151 33.1 µM -0.960882244315212 0.181938876721892 no 2780 0.168305689696641 4071 6166523
SGTC_1493 4348-0038 111 µM -0.963153456173041 0.181338321542777 no 2781 0.167735259330199 4023 800424
SGTC_2427 5545055 42.75 µM -0.964293145454833 0.181037432481041 no 2782 0.167449488239812 4012 5372858
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.964412865445743 0.181005843404054 no 2783 0.16741948729982 3959 5355888
SGTC_2776 terbinafine 19.92 µM -0.966677975146993 0.180408827064342 no 2784 0.166852520389411 4077 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1316 1272-0050 65.9 µM -0.967514706690944 0.180188602050356 no 2785 0.16664339645128 4006 7340392
SGTC_2614 arthonioic acid 13.39 µM -0.968938803043902 0.179814172705677 no 2786 0.166287861809273 3933 6710684
SGTC_208 k072-0098 12.366 µM -0.969869575782674 0.179569714367894 no 2787 0.166055753441183 4026 5948901
SGTC_1842 st055362 61.2 µM -0.970552038357849 0.179390605047131 no 2788 0.165885699676274 4013 676032
SGTC_1590 st077108 57.8 µM -0.970785303105463 0.179329411498847 no 2789 0.165827601359232 4084 5489485
SGTC_483 fpl-64176 144 µM -0.97159557056465 0.179116951843396 no 2790 0.165625893497282 4114 3423
SGTC_1731 st035964 63 µM -0.972696032017056 0.178828654310466 no 2791 0.165352198973553 4010 6739575
SGTC_860 0443-0016 25.1 µM -0.973892028258895 0.178515660114208 no 2792 0.165055076143849 4086 5337942
SGTC_1299 1079-1439 3.74 µM -0.975201428991389 0.1781733837157 no 2793 0.164730176724506 4021 323161
SGTC_1037 k284-1091 78.7 µM -0.975676256074324 0.178049366529268 no 2794 0.164612461106311 4041 3334711
SGTC_3206 9114350 49.47 µM -0.977862376759996 0.177479089368191 no 2795 0.164071197626177 3973 17087243
SGTC_809 3998-0021 90 µM -0.978468078336237 0.177321288675233 no 2796 0.163921435939339 4012 715485
SGTC_1737 st035557 69.7 µM -0.978529461116865 0.177305301842455 no 2797 0.163906263798667 3942 5716916
SGTC_1032 k061-1018 98.7 µM -0.979978789493688 0.176928096115798 no 2798 0.163548294336358 4182 4005393
SGTC_678 1218-2179 85.9 µM -0.980353224748225 0.176830727179493 no 2799 0.163455895196589 4045 6820081 YOR116C RPO31
SGTC_3267 9137951 49.47 µM -0.980507664714651 0.176790576151674 no 2800 0.163417794026514 4092 16643986
SGTC_952 1185-0122 232 µM -0.980936839507843 0.176679030314219 no 2801 0.163311944589602 3992 678600
SGTC_174 3553-0389 74.3 µM -0.981550698932996 0.176519560879736 no 2802 0.163160622932366 4143 738071
SGTC_1 0258-0098 57.368 µM -0.982715751309204 0.176217152057162 no 2803 0.162873678106774 4011 6790032 YDR047W HEM12
SGTC_2440 5628896 157.78 µM -0.98372718037697 0.175954884781315 no 2804 0.162624835954635 4060 5522048
SGTC_2397 5161689 200 µM -0.985836561231728 0.175408710330965 no 2805 0.162106660684529 4135 2259942
SGTC_2683 piperine 63.03 µM -0.988569214961751 0.174702753956586 no 2806 0.161436977215772 4057 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1166 k206-0078 225 µM -0.988762439042833 0.174652904637812 no 2807 0.16138969274324 4067 5404595
SGTC_1142 3253-1408 9.78 µM -0.989448422763079 0.174476002647605 no 2808 0.161221896469761 4077 256655
SGTC_3196 9111891 49.47 µM -0.990177715453393 0.174288056967996 no 2809 0.16104363138949 4052 18891510
SGTC_2399 5884133 200 µM -0.991121654327707 0.174044986004251 no 2810 0.16081309021463 4085 722445
SGTC_2714 st079313 56.9 µM -0.992065588522213 0.173802131864881 no 2811 0.160582765764955 4046 2939799
SGTC_273 hydroxyurea 18.1 mM -0.994028073144803 0.17329791667272 no 2812 0.160104600184822 4151 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2735 sertaconazole 140 nM -0.994677447792832 0.173131280106422 no 2813 0.159946583191437 4209 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3077 9117319 49.47 µM -0.995115160124382 0.173019015981332 no 2814 0.159840129075481 4054 17154678
SGTC_978 1416-0512 87.4 µM -0.999457475395886 0.171907815343685 no 2815 0.15878656461296 4179 6814003
SGTC_1089 terbinafine 2.25 µM -0.999873115704761 0.171801692266468 no 2816 0.158685958164125 4098 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2101 5377231 179.231 µM -1.00170422417943 0.171334664075401 no 2817 0.15824323295932 4137 2844213
SGTC_1309 pyrazolanthrone 13.4 µM -1.00204101469621 0.171248853370262 no 2818 0.158161892119993 4068 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_75 0159-0059 199.013 µM -1.00442046289045 0.170643377894782 no 2819 0.157587995428975 4205 5377270
SGTC_2687 chenodiol 100 µM -1.00528471785421 0.170423798876946 no 2820 0.157379885816255 4186 5702181 A cholesterol synthesis inhibitor.
SGTC_1925 st057770 10.1 µM -1.00712401289156 0.169957096605693 no 2821 0.156937591514572 4081 5989122
SGTC_1882 5615643 20 µM -1.00811064721906 0.169707086200144 no 2822 0.156700673391913 4047 2253075
SGTC_1307 1187-1599 12.2 µM -1.00893607582936 0.169498106191268 no 2823 0.156502646159046 4072 1538471
SGTC_739 1486-1183 203 µM -1.01018619327231 0.169181919055876 no 2824 0.156203046412373 4107 4346692
SGTC_418 lividomycin a 100 µM -1.01200632932405 0.168722236985067 no 2825 0.155767513583251 4122 72394 An antibiotic.
SGTC_616 4092-0450 108 µM -1.01219581059748 0.168674428964008 no 2826 0.155722219456236 4117 787165
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.01235749972035 0.168633640066093 no 2827 0.155683575710248 4113 688751
SGTC_1170 0310-0127 64.8 µM -1.0138121397148 0.168266966917519 no 2828 0.155336200752773 4124 774975
SGTC_779 1360-0071 233 µM -1.01732476131509 0.167383651694376 no 2829 0.154499480510138 4161 7566
SGTC_1321 1326-2144 215 µM -1.02040582207251 0.166611325140766 no 2830 0.153768016909751 4121 3513030
SGTC_2446 5162541 200 µM -1.02116107089585 0.166422359187409 no 2831 0.153589066396065 4079 1549321
SGTC_442 cape 100 µM -1.02196601117488 0.166221112647358 no 2832 0.153398493739544 4094 5281787
SGTC_1933 st074711 15.9 µM -1.02364252811164 0.165802464380102 no 2833 0.153002075088067 4086 17250958
SGTC_3078 9116413 49.47 µM -1.02722407937494 0.164910389672677 no 2834 0.152157481067032 4050 17177322
SGTC_386 1509-0011 3.07 µM -1.02772818834762 0.164785078754401 no 2835 0.152038852144281 4119 3107280
SGTC_2807 7945238 51.95 µM -1.02938929342783 0.164372599479223 no 2836 0.151648389109883 4153 17148797
SGTC_858 0438-0351 2.77 µM -1.03002234456069 0.16421557894786 no 2837 0.151499758272754 4085 2799119
SGTC_2086 5274770 176.623 µM -1.03008245645257 0.164200673992511 no 2838 0.151485649945857 4153 689278
SGTC_331 k048-0133 24.5 µM -1.03035503302171 0.164133098681421 no 2839 0.151421686887835 4087 6813582
SGTC_2779 methotrexate 400 µM -1.03144913382676 0.163862038263251 no 2840 0.151165124967727 4140 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3038 9091290 49.47 µM -1.03187549413392 0.163756487394846 no 2841 0.151065223669335 4157 25236843
SGTC_839 0122-0028 230 µM -1.03394282795186 0.163245318792718 no 2842 0.150581445798588 4119 759448
SGTC_1252 0493-0875 34.8 µM -1.03479694718332 0.163034432402321 no 2843 0.150381874464633 4121 3960963
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.04172842248381 0.161329569247504 no 2844 0.148768803815243 4142 229346 A bile salt which induces apoptosis.
SGTC_2488 5268135 45.7 µM -1.04258344798647 0.161120076036971 no 2845 0.148570629253171 4191 1270356 YLR208W SEC13
SGTC_1085 doxorubicin 7.67 µM -1.04292125597569 0.161037357293628 no 2846 0.148492382065517 4163 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1366 1683-0113 21.9 µM -1.0439074936005 0.160796016760557 no 2847 0.148264095429247 4140 708623
SGTC_2002 4023503 131 µM -1.04645392042639 0.160173977590552 no 2848 0.147675754525988 4145 4736863 YCR052W RSC6
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.04682776921253 0.160082786704222 no 2849 0.147589510193899 4146 688669
SGTC_2497 7-hydroxyflavone 100 µM -1.04782611697676 0.159839431600673 no 2850 0.147359363642795 4160 5281894
SGTC_1067 clotrimazole 1.36 µM -1.04829701508812 0.15972473052731 no 2851 0.147250892226808 4164 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3025 9087895 49.47 µM -1.04976502978572 0.159367498142095 no 2852 0.146913078495115 4131 17173641
SGTC_147 4466-0538 29.23 µM -1.05327446293982 0.158515620872466 no 2853 0.14610760971667 4246 6742687 YHR072W ERG7
SGTC_1744 st037937 38.9 µM -1.05360459750463 0.158435638216208 no 2854 0.146031991713738 4223 1016152
SGTC_1633 st005664 67.9 µM -1.05402814553238 0.158333062785085 no 2855 0.145935015676463 4135 2063822
SGTC_2546 rhodinyl acetate 100 µM -1.05429325854807 0.158268879535065 no 2856 0.145874337124929 4102 6708682
SGTC_643 k048-0106 28.4 µM -1.06228922476476 0.156341097985725 no 2857 0.144052202286298 4160 6763920
SGTC_1290 0986-0249 10.2 µM -1.06344693996458 0.156063266663689 no 2858 0.143789657710485 4024 53329
SGTC_2372 9071633 200 µM -1.06432701081832 0.155852282925704 no 2859 0.143590292944311 4186 21321366
SGTC_1027 k015-0025 8.67 µM -1.06861491846144 0.154827012889348 no 2860 0.142621611726786 4128 3598955
SGTC_126 0417-1624 672.48 µM -1.06875542002859 0.154793493499628 no 2861 0.142589945962248 4224 41912 YDL195W SEC31
SGTC_1326 1431-2094 10.8 µM -1.07075251162228 0.15431756674047 no 2862 0.142140362319965 4144 616278
SGTC_2378 9074213 121.43 µM -1.07152136648271 0.154134599227033 no 2863 0.14196753438345 4132 657714
SGTC_488 nitrendipine 139 µM -1.07250221568265 0.153901390948445 no 2864 0.141747259649121 4199 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_688 0527-0193 473 µM -1.07395749082997 0.153555812857006 no 2865 0.141420867167804 4233 4007154
SGTC_2468 5987765 72.9 µM -1.07529232127943 0.153239288445806 no 2866 0.141121936492136 4211 26772094
SGTC_2496 diffractaic acid 79.83 µM -1.07673064585147 0.15289870703027 no 2867 0.140800308572744 4196 94870 An apoptosis inducer which activates caspases.
SGTC_2799 7812892 81.82 µM -1.07705836547884 0.152821176439178 no 2868 0.140727095863637 4198 20205235
SGTC_1065 prochlorperazine maleate 2.48 µM -1.08181198272191 0.151699516870295 no 2869 0.13966804051753 4206 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_993 3909-8757 62.7 µM -1.08293162363714 0.151436125478709 no 2870 0.139419387003606 4112 4288324 YLR208W SEC13
SGTC_620 0109-0052 432 µM -1.08425766370642 0.15112457301822 no 2871 0.139125285431181 4178 493037
SGTC_2122 5258151 111.688 µM -1.08535468368275 0.150867151277488 no 2872 0.138882297462991 4172 2173356
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.0854741958069 0.150839124745497 no 2873 0.138855843207397 4204 5377381
SGTC_3008 9078912 71.4286 µM -1.08847240876024 0.15013715440656 no 2874 0.13819330530805 4176 16648731
SGTC_713 1488-1073 324 µM -1.08883724766171 0.150051883685676 no 2875 0.138112831425562 4144 3312542
SGTC_1339 1486-1321 22.7 µM -1.08895123188497 0.150025249735021 no 2876 0.138087696051465 4201 3469382
SGTC_216 k038-0035 28.382 µM -1.08918896291851 0.149969710816745 no 2877 0.138035282532575 4111 4444231 YPR107C YTH1
SGTC_336 4111-0029 111 µM -1.08944233829832 0.149910532148342 no 2878 0.137979434780368 4175 3131175
SGTC_2767 sibutramine 71.45 µM -1.09098436463799 0.1495507103918 no 2879 0.137639881271599 4210 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2280 7785178 200 µM -1.09450661819604 0.148730979021361 no 2880 0.136866423177375 4173 2954328
SGTC_1215 3852-0577 11.2 µM -1.09452142512299 0.148727539367843 no 2881 0.136863177980224 4237 2884876
SGTC_802 4112-3352 742 µM -1.09642751031922 0.148285199160253 no 2882 0.136445865153498 4255 704594
SGTC_1484 3473-2379 286 µM -1.09770904587615 0.147988291827815 no 2883 0.136165779245867 4314 671917
SGTC_3156 9099931 49.47 µM -1.09856310551548 0.147790643615597 no 2884 0.135979338946108 4222 18111053
SGTC_1914 st062367 72.6 µM -1.09899718023385 0.147690256942882 no 2885 0.135884647918652 4182 978205
SGTC_490 phenamil 164 µM -1.09933132944924 0.147613010744861 no 2886 0.135811785857231 4159 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1198 1612-1005 86.7 µM -1.09993755316691 0.14747293742863 no 2887 0.135679665592168 4264 6998509
SGTC_82 0054-0107 293.755 µM -1.10176160386744 0.147052011742171 no 2888 0.135282663494093 4154 3104697
SGTC_726 3448-4391 34.2 µM -1.10275326218571 0.146823510825869 no 2889 0.135067164905085 4314 1356692
SGTC_505 gw-5074 63.9 µM -1.10287600595788 0.146795244408257 no 2890 0.135040507674298 4220 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2098 5376439 882.5 nM -1.1033720068188 0.146681058548019 no 2891 0.134932824015395 4239 2844116
SGTC_2234 tolnaftate 200 µM -1.10361365873511 0.146625448726222 no 2892 0.134880381817022 4246 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1182 1222-0449 220 µM -1.10409235038755 0.146515332231876 no 2893 0.134776539621162 4189 658318
SGTC_475 α-linolenic acid 10 µM -1.10540094006691 0.146214592344318 no 2894 0.134492948308144 4214 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1146 3579-1023 7 µM -1.10903075849168 0.145382559249077 no 2895 0.133708456580269 4231 X1146
SGTC_1072 oxiconazole 14.9 nM -1.10907157020919 0.145373222460429 no 2896 0.133699654100637 4185 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1638 st008370 60.6 µM -1.11066050501694 0.145010024021687 no 2897 0.13335725421203 4154 24207134
SGTC_2752 diclazuril 33.15 µM -1.11333013299139 0.144401177251323 no 2898 0.132783334708597 4158 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_3018 9082602 49.47 µM -1.11561846060612 0.143880664618749 no 2899 0.132292743323862 4148 17332089
SGTC_638 3970-0837 4.09 µM -1.11673564378891 0.143627005789057 no 2900 0.132053686410546 4184 4118451 YLR208W SEC13
SGTC_1539 benzyladenosine 56 µM -1.11866276458995 0.143190158621091 no 2901 0.131642018037701 4200 92208 A nucleotide analog.
SGTC_1317 1273-0028 910 nM -1.11942580386989 0.143017438222648 no 2902 0.13147926386349 4203 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1941 st076221 61.8 µM -1.12264884078682 0.142289430093275 no 2903 0.130793331810396 4096 2828568
SGTC_2897 9048598 12.99 µM -1.12796003376556 0.141095235546317 no 2904 0.129668399103272 4207 6467404
SGTC_721 1187-1332 279 µM -1.12811081258731 0.141061433205965 no 2905 0.129636561645451 4176 25730
SGTC_556 4058-0063 51.5 µM -1.12814779687195 0.141053142725341 no 2906 0.129628753115764 4255 6615692
SGTC_3285 9112818 20.8695 µM -1.12903573029792 0.140854200765202 no 2907 0.129441380625753 4200 17017947 YPR165W RHO1
SGTC_1816 st051957 91.6 µM -1.13013491663857 0.140608191275341 no 2908 0.129209689420335 4209 674121
SGTC_677 0929-0063 136 µM -1.13053369552444 0.14051901249444 no 2909 0.129125704208025 4218 1539583
SGTC_585 0kpi-0023 191 µM -1.13284313046076 0.140003309526269 no 2910 0.128640067730975 4156 64601
SGTC_1944 st076371 56.9 µM -1.13426358807013 0.139686757114169 no 2911 0.12834199895838 4193 24208455
SGTC_2393 9031399 185.94 µM -1.13502462915213 0.139517357630544 no 2912 0.128182499554026 4261 1526623 YDL150W RPC53
SGTC_2931 9014674 55.67 µM -1.13580404310826 0.139344013421822 no 2913 0.128019292295833 4196 2996810
SGTC_591 4299-0174 154 µM -1.13783391915022 0.138893250327065 no 2914 0.127594919278575 4241 5509088
SGTC_745 0469-0705 296 µM -1.13917072259316 0.138596936785401 no 2915 0.127315977167161 4285 3486736
SGTC_1023 4482-3888 16 µM -1.1404229939921 0.138319751433129 no 2916 0.127055058862923 4239 3303168
SGTC_171 k064-0041 9.68 µM -1.14298846908516 0.137753074309265 no 2917 0.12652168931307 4258 53325
SGTC_2282 7944268 200 µM -1.14368135603112 0.137600297485764 no 2918 0.126377904049621 4259 2970414
SGTC_332 4112-0506 40.9 µM -1.14744065092618 0.136773415027231 no 2919 0.125599774259789 4198 2790355
SGTC_555 4296-0685 37 µM -1.14829894649598 0.136585104384582 no 2920 0.125422586941879 4216 2908540 YHR072W ERG7
SGTC_1931 st074438 57.1 µM -1.15029861555262 0.136147063595194 no 2921 0.125010450423234 4240 2787313
SGTC_1513 0337-0559 19 µM -1.15036381755912 0.13613279686727 no 2922 0.12499702807957 4220 775073
SGTC_3239 9133757 49.47 µM -1.15039491390569 0.136125993094772 no 2923 0.124990627007655 4271 17036923
SGTC_2323 6148992 148.28 µM -1.15241341552721 0.135684849776952 no 2924 0.124575615399852 4218 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2666 tannic acid 100 µM -1.15362179582956 0.1354212274934 no 2925 0.124327629265156 4233 16134267 A thiamine antagonist.
SGTC_2550 chrysin dimethyl ether 71.87 µM -1.15472100682832 0.135181726841634 no 2926 0.124102347119063 4081 88881 An O-methylated flavonoid and antioxidant.
SGTC_581 0958-0271 211 µM -1.15569806315399 0.134969085691434 no 2927 0.123902340342804 4240 4591145
SGTC_1443 4112-3303 14 µM -1.15579948631708 0.134947025664552 no 2928 0.123881591606378 4292 704433
SGTC_3346 9158254 43.5805 µM -1.1575753059664 0.134561177055699 no 2929 0.12351869570699 4242 17639500
SGTC_1294 1000-1494 117 µM -1.15830418859392 0.134403025462518 no 2930 0.12336996133756 4234 712797 YDL207W GLE1
SGTC_286 k060-0067 22.9 µM -1.158403561314 0.134381473645307 no 2931 0.123349693257305 4267 5985051
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.16031265380747 0.133967892990257 no 2932 0.122960767223107 4277 61125 An anti-inflammatory.
SGTC_36 0335-0881 14.2 µM -1.16049040728317 0.133929429515619 no 2933 0.122924598554587 4135 23828853
SGTC_2031 5180455 200 µM -1.16085172975317 0.13385126755988 no 2934 0.122851100889931 4209 29949
SGTC_2225 6654152 15.4 µM -1.16534897329758 0.132881038769019 no 2935 0.121938881525215 4152 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_981 1488-1094 54.9 µM -1.16614305292174 0.132710229454242 no 2936 0.121778306170652 4223 3449522
SGTC_1016 4226-1401 38 µM -1.16676408469362 0.132576748768084 no 2937 0.121652827379239 4227 2901613
SGTC_3009 9080819 71.4286 µM -1.16983202730394 0.131918701626605 no 2938 0.121034286123498 4278 17027216
SGTC_647 0140-0236 81 µM -1.17217440932366 0.131417800096895 no 2939 0.1205635202292 4274 990837
SGTC_2228 7354201 200 µM -1.1730144317259 0.131238487657645 no 2940 0.120395009200292 4337 753451
SGTC_596 1155-0152 116 µM -1.17593691448206 0.130615966983597 no 2941 0.119810043132713 4263 280313
SGTC_850 0388-0143 75.9 µM -1.1771887472537 0.130349938533547 no 2942 0.119560089503338 4240 67273
SGTC_215 1287-0124 461.5 µM -1.17769022656928 0.130243473796512 no 2943 0.119460062322281 4273 5560863
SGTC_2937 9044753 11.33 µM -1.17991038755172 0.12977285349666 no 2944 0.119017929008411 4209 6465530 YGL099W LSG1
SGTC_3341 9147222 25.867 µM -1.18077553021055 0.129589783465003 no 2945 0.118845953659611 4272 1939759
SGTC_2303 7774051 200 µM -1.18417965926608 0.12887118399446 no 2946 0.11817097611037 4299 2953184
SGTC_214 4373-3496 70 µM -1.18481127439064 0.128738156880108 no 2947 0.118046036944407 4361 3779166
SGTC_1727 st034309 9.9045 µM -1.18682074005942 0.128315568700719 no 2948 0.117649168098591 4341 870305
SGTC_294 k038-0071 157 µM -1.18820423019166 0.128025182834875 no 2949 0.117376478754072 4286 24152826
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.19026331645059 0.127593839494417 no 2950 0.116971457050017 4328 6710655
SGTC_1901 st060216 58.6 µM -1.19193151153736 0.127245122831719 no 2951 0.116644050547731 4244 688792
SGTC_2943 9068529 45.32 µM -1.19476435509438 0.126654470078167 no 2952 0.11608955529785 4263 3270634
SGTC_2869 9037858 32.47 µM -1.1965050795369 0.126292474601893 no 2953 0.115749758772287 4240 27187042
SGTC_2782 7736369 71.43 µM -1.19992806805549 0.125582745322582 no 2954 0.115083639005101 4295 2950836 YOL077C BRX1
SGTC_40 0327-0103 19.753 µM -1.20082851553904 0.125396507993882 no 2955 0.114908864027597 4137 409036
SGTC_786 4544-0069 423 µM -1.20289682464909 0.124969454966476 no 2956 0.114508124642099 4275 748821 YLR208W SEC13
SGTC_2307 7538926 6.34 µM -1.20368026558625 0.124807960020959 no 2957 0.114356591328508 4243 96582
SGTC_812 4251-0442 148 µM -1.20480629919873 0.124576100101771 no 2958 0.114139043830472 4317 5723007
SGTC_1646 st011709 75.6 µM -1.20506413390159 0.124523052132811 no 2959 0.114089272171603 4249 5757843
SGTC_2338 7999974 200 µM -1.20713350986116 0.124097862245855 no 2960 0.11369036579835 4284 315925
SGTC_203 k066-0004 30.888 µM -1.20912608730548 0.123689412913323 no 2961 0.113307204128144 4370 6795412
SGTC_2202 7226349 200 µM -1.20934604172528 0.123644383218216 no 2962 0.113264964624858 4262 844334
SGTC_399 oxolinic acid 75 µM -1.21003991690131 0.123502406346346 no 2963 0.113131788166066 4272 4628 A DNA gyrase inhibitor.
SGTC_2788 5282734 71.43 µM -1.21166155245901 0.123171041700308 no 2964 0.112820981119846 4371 743706
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.21933251635956 0.121612005430252 no 2965 0.111359005922883 4347 23847180
SGTC_71 0417-1750 47.813 µM -1.22678420554937 0.120110864663793 no 2966 0.109951854377503 4299 6811472
SGTC_614 0462-0418 107 µM -1.22790870907851 0.119885472609718 no 2967 0.10974061990932 4076 5188303
SGTC_3132 9126706 49.47 µM -1.22840819604896 0.11978545266519 no 2968 0.109646886339679 4361 850858
SGTC_2499 avocadenofuran 51.48 µM -1.22844544903953 0.11977799528551 no 2969 0.109639897759156 4265 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2516 gossypol 71.55 µM -1.22853250291697 0.119760569939024 no 2970 0.109623567886761 4326 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2582 agaric acid 100 µM -1.2294327445327 0.119580475755405 no 2971 0.109454799795996 3954 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2191 5911152 200 µM -1.23228112047524 0.119011914182347 no 2972 0.108922044872359 4331 2875902
SGTC_2327 6189656 200 µM -1.2356623393105 0.11833947349167 no 2973 0.108292050978962 4398 5349088
SGTC_2171 5739187 198.077 µM -1.23585208550011 0.11830181742996 no 2974 0.108256775049072 4249 2262761
SGTC_1122 capsaicin 818.572 nM -1.23877355599464 0.117723106389265 no 2975 0.107714684793952 4361 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_143 4032-1194 15.74 µM -1.24230108785531 0.117027015041218 no 2976 0.107062747072289 4356 1806963
SGTC_3317 9138495 8.753 µM -1.24362517433912 0.116766486093972 no 2977 0.106818773261077 4231 17020139
SGTC_489 paxilline 115 µM -1.2440152171335 0.116689819237535 no 2978 0.106746981222047 4304 105008 A toxic potassium channel blocker.
SGTC_374 0880-0231 82.3 µM -1.24841427900979 0.115827609736065 no 2979 0.105939691269305 4199 6833587
SGTC_1414 3917-0015 5.4 µM -1.24853243425404 0.115804514040804 no 2980 0.105918069124866 4325 6618702
SGTC_1613 st002381 52.1 µM -1.24969395546505 0.115577646661689 no 2981 0.105705683113935 4312 551167
SGTC_2203 7227154 166.4 µM -1.25016008782003 0.115486690911158 no 2982 0.10562053669847 4346 896304
SGTC_625 k213-0058 121 µM -1.25052908266682 0.115414725541755 no 2983 0.105553169154552 4396 3655420
SGTC_1900 st060200 72.8 µM -1.25167418476383 0.115191598260687 no 2984 0.105344305236846 4331 688945
SGTC_398 bronopol 33.3 µM -1.25306273583097 0.114921445686193 no 2985 0.105091438095698 4250 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2219 9098279 200 µM -1.25601527168995 0.114348507250001 no 2986 0.104555216600752 4272 902349
SGTC_428 3448-4153 16.5 µM -1.25731325158738 0.114097279368897 no 2987 0.104320113678799 4299 3834874
SGTC_227 fluconazole 33.516 µM -1.25905814756265 0.113760169443706 no 2988 0.104004664958745 4330 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1416 3966-0321 25.3 µM -1.26447171672977 0.11271879986752 no 2989 0.103030383038877 4370 582530 YLR208W SEC13
SGTC_2586 curcumin 80 µM -1.26537862758292 0.112545011747719 no 2990 0.102867816433104 4238 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1720 st037298 9.481 µM -1.26547773359688 0.112526032019177 no 2991 0.102850062672613 4331 597396
SGTC_2362 9071156 126 µM -1.26686789315044 0.112260044396281 no 2992 0.102601265368568 4353 653133
SGTC_2961 9083290 32.55 µM -1.26690789099448 0.112252398022913 no 2993 0.102594113422086 4282 17741490
SGTC_1957 st077035 62.4 µM -1.26845860080732 0.11195623628515 no 2994 0.102317112961068 4345 705593
SGTC_2875 9039966 71.43 µM -1.27087721763913 0.111495433632743 no 2995 0.101886166261843 4348 6463691
SGTC_1511 0906-3109 28.5 µM -1.27313788018297 0.111065953597185 no 2996 0.10148455957994 4347 2882180
SGTC_811 0416-0114 265 µM -1.273762624241 0.110947474123727 no 2997 0.101373777418537 4378 6612453
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.27538634175963 0.110639967998809 no 2998 0.101086265290762 4405 279621
SGTC_2059 5238311 157 µM -1.2788109978486 0.109993396840394 no 2999 0.100481810062876 4306 703021
SGTC_2178 5812956 200 µM -1.27972078139299 0.109822087446291 no 3000 0.100321676603526 4302 5403383
SGTC_2414 st077232 92.9 µM -1.28373419717441 0.10906865953182 no 3001 0.0996174873166951 4282 729801
SGTC_1060 3448-7350 82 µM -1.29406646439336 0.107146120312608 no 3002 0.0978212320059868 4289 570178
SGTC_3146 9095609 49.47 µM -1.29483048157222 0.107004935092547 no 3003 0.0976893571604498 4405 17173999
SGTC_3092 9117248 49.47 µM -1.29902457940516 0.106232284050085 no 3004 0.0969677470389826 4487 17141857
SGTC_3122 9126309 49.47 µM -1.30516432018813 0.105108479985553 no 3005 0.095918450365933 4459 17591206
SGTC_1415 3966-0071 78.1 µM -1.30858322465117 0.104486433565822 no 3006 0.0953377831995394 4287 2893185
SGTC_2773 thioridazine 9.09 µM -1.31172433170291 0.103917285371053 no 3007 0.0948065819868232 4351 5452 An antipsychotic.
SGTC_521 r062-0005 13.8 µM -1.31743521087413 0.102888277476189 no 3008 0.0938463924204411 4301 2832033
SGTC_1677 st019204 53.9 µM -1.32330280850816 0.101838762889742 no 3009 0.0928673490525558 4394 3945625
SGTC_2934 9036370 36.88 µM -1.32400090529489 0.101714417594409 no 3010 0.0927513720266433 4360 6462800
SGTC_2487 5918373 44.05 µM -1.32428179275683 0.101664416998677 no 3011 0.0927047375359511 4433 2876279
SGTC_3 0833-0587 95.581 µM -1.32482536687938 0.101567706552444 no 3012 0.0926145396075146 4254 5382644
SGTC_1547 harmine 94.2 µM -1.32541953726739 0.101462070888762 no 3013 0.0925160202700681 4312 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_612 0302-0167 22.4 µM -1.3287574761173 0.100870116652588 no 3014 0.0919639978549582 4394 235821
SGTC_659 k018-0002 107 µM -1.32966365320988 0.100709849538779 no 3015 0.0918145577190717 4358 6797879 YHR007C ERG11
SGTC_417 st075190 100 µM -1.33372198255858 0.0999943686980953 no 3016 0.0911474938517833 4376 222757
SGTC_113 0099-0221 2.5 µM -1.33458487826992 0.0998427204362757 no 3017 0.0910061249720501 4360 89219
SGTC_2192 5915882 198.485 µM -1.33603235855108 0.0995887126387718 no 3018 0.0907693484932638 4360 2876149
SGTC_1040 k898-0338 155 µM -1.33752243230073 0.0993277240351863 no 3019 0.0905260824844064 4381 20969351
SGTC_1700 st030840 7.9285 µM -1.33863712520467 0.0991328111417083 no 3020 0.0903444170025567 4420 5499307
SGTC_1671 st016596 74.5 µM -1.34022619845699 0.0988554329190762 no 3021 0.090085908334092 4447 2829167
SGTC_1798 st045719 60.953 µM -1.34418594745652 0.0981667165538116 no 3022 0.0894441323312492 4353 3980186
SGTC_1425 4048-4433 7.33 µM -1.34501069684349 0.0980237118491555 no 3023 0.0893108901035605 4459 23734946
SGTC_351 caspofungin 25 nM -1.34686468474413 0.0977028031037233 no 3024 0.0890119086123129 4396 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1714 st033236 13.627 µM -1.34874677272514 0.0973778190317546 no 3025 0.0887091582697785 4418 2916566
SGTC_1545 lovastatin 49.4 µM -1.34943519250243 0.0972591464408048 no 3026 0.0885986116824834 4432 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2856 9022925 19.48 µM -1.35121677629618 0.0969525225350735 no 3027 0.0883130010486554 4422 4944862
SGTC_2451 5856223 45.7 µM -1.35373442513478 0.0965204272231489 no 3028 0.0879105605305004 4393 2179896
SGTC_816 0325-0417 81.3 µM -1.35417220936536 0.0964454364617024 no 3029 0.0878407215128609 4439 68101
SGTC_1245 0418-0076 17.2 µM -1.35450459754911 0.0963885282372947 no 3030 0.0877877238015848 4423 6790114
SGTC_64 000l-0018 272.079 µM -1.35673192776466 0.0960078233102848 no 3031 0.0874332018958483 4327 6811119
SGTC_330 1488-0319 80.1 µM -1.3571983963349 0.0959282327057953 no 3032 0.0873590900862514 4445 6846614
SGTC_3013 9080133 71.4286 µM -1.3581857203851 0.0957599318694436 no 3033 0.0872023802462934 4471 17050193
SGTC_170 4197-0004 226 µM -1.36330418048235 0.0948909120371643 no 3034 0.0863933325301853 4401 218692
SGTC_471 1-acyl-paf 4 µM -1.36854103840641 0.0940078183512497 no 3035 0.0855713927492004 4380 16759367
SGTC_2251 lansoprazole 556 µM -1.37169406937534 0.0934790544896015 no 3036 0.0850793477097122 4373 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_144 4161-2749 112.381 µM -1.37194768287918 0.0934366191018053 no 3037 0.0850398624795991 4396 797501 YMR168C CEP3
SGTC_1481 3346-2004 36 µM -1.3726520616501 0.0933188349320494 no 3038 0.0849302693974228 4497 2770522
SGTC_2272 7805186 180 µM -1.37490459160906 0.0929429097367941 no 3039 0.0845805127922682 4425 2956062 YPR165W RHO1
SGTC_2115 tiliquinol 12.7705 µM -1.37948922833288 0.0921812390744178 no 3040 0.0838719825538026 4407 71208 A bioactive hydroxyquinoline.
SGTC_1503 4585-0012 61.3 µM -1.3835126038646 0.0915166290889297 no 3041 0.0832538726974302 4438 2922052
SGTC_1856 st057054 55.7 µM -1.38405956341456 0.0914265532925475 no 3042 0.0831701086098584 4416 1266018
SGTC_1904 st060225 78 µM -1.38759580630447 0.0908457740353406 no 3043 0.0826300795933729 4400 66595
SGTC_256 clotrimazole 625 nM -1.38900870288754 0.0906144921454108 no 3044 0.0824150518283862 4361 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2618 avocadyne 43.43 µM -1.39183822837683 0.0901526319863526 no 3045 0.0819856954142488 4352 3015189
SGTC_847 0342-0274 5.54 µM -1.3957180222546 0.0895221838256178 no 3046 0.0813997124993909 4426 18097
SGTC_1772 st048439 82.2 µM -1.39821537665677 0.0891181136298656 no 3047 0.0810242003049963 4469 2927068 YDL195W SEC31
SGTC_1998 st075797 76.8 µM -1.39923991913049 0.088952736586078 no 3048 0.0808705247772498 4415 24208315
SGTC_1168 k815-0004 80.5 µM -1.40123815428638 0.0886308479336204 no 3049 0.0805714341601841 4426 642433
SGTC_2739 tacrine 100.86 µM -1.40571368939376 0.087913048807259 no 3050 0.0799045801509961 4498 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2386 9075165 157.42 µM -1.4080899666096 0.0875337010833218 no 3051 0.0795522158214616 4417 16452277
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.41530495585551 0.0863893896071422 no 3052 0.0784895512920401 4450 7104
SGTC_611 3453-1652 23.7 µM -1.41589655696511 0.0862960590469596 no 3053 0.078402896585004 4454 1560575
SGTC_1534 6-azauridine 81.6 µM -1.4164800222196 0.0862040858724625 no 3054 0.07831750464231 4472 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_605 1315-0399 119 µM -1.41702526878203 0.0861182035039391 no 3055 0.0782377698883485 4516 24020461
SGTC_1154 4088-0362 150 µM -1.42625053257708 0.084674810233121 no 3056 0.07689801897335 4455 6618304
SGTC_972 1319-0219 195 µM -1.42807002310384 0.0843922856502566 no 3057 0.0766358523703405 4441 23903702
SGTC_2952 9073731 13.78 µM -1.43045714224905 0.0840226950460938 no 3058 0.0762929289838205 4453 16457353
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.4324255355608 0.0837188498324447 no 3059 0.0760110374418645 4542 688664
SGTC_2593 nobiletin 86.24 µM -1.43526001511944 0.083282764908845 no 3060 0.0756065086591756 4434 72344 An anti-infammatory.
SGTC_2140 5586273 200 µM -1.4354549136207 0.0832528426239905 no 3061 0.0755787536909338 4425 854421
SGTC_1629 st005085 44.9 µM -1.43724617801137 0.082978212647908 no 3062 0.0753240280172336 4415 24207091
SGTC_3066 9117245 49.47 µM -1.43756631435001 0.0829292023969257 no 3063 0.0752785722330904 4504 17176980
SGTC_818 4072-2707 53.5 µM -1.43843921647775 0.0827956788700708 no 3064 0.0751547361273666 4387 882871
SGTC_527 4476-4215 268 µM -1.43993990935415 0.0825665034956797 no 3065 0.0749422003227771 4460 4418754
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.44379508916624 0.0819799565203579 no 3066 0.0743983118997814 4416 6857784
SGTC_307 1501-1223 22.3 µM -1.44629591170964 0.0816011508417281 no 3067 0.0740471109819086 4495 2830329
SGTC_1559 coumarin 343 70.1 µM -1.44819883053372 0.081313796398345 no 3068 0.0737807257863491 4508 108770 A hepatotoxic, DNA x-linker.
SGTC_3172 9105863 49.47 µM -1.44924391729414 0.0811563058562548 no 3069 0.0736347384482704 4562 2348785
SGTC_1867 st057372 64 µM -1.45393956140544 0.0804515297675942 no 3070 0.0729815316503285 4434 688837
SGTC_1574 spiramycin 23.7 µM -1.45515318803307 0.0802701289716315 no 3071 0.0728134285764967 4434 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_145 3737-0113 38.366 µM -1.46244590370453 0.0791865905549424 no 3072 0.0718095290873354 4453 6849351
SGTC_1702 st027038 51 µM -1.46888039696986 0.0782397937036244 no 3073 0.0709326162653172 4500 5521182
SGTC_3067 9117431 49.47 µM -1.46906464036717 0.0782128103921407 no 3074 0.0709076286820279 4481 17150885
SGTC_3088 9117578 49.47 µM -1.47076848081614 0.0779636093025984 no 3075 0.0706768695773698 4545 678341
SGTC_664 1222-0054 14.9 µM -1.47179003912945 0.0778144869166728 no 3076 0.0705387921375858 4449 6813991
SGTC_3356 9151811 4.48 µM -1.47440732968998 0.0774334147779099 no 3077 0.0701859760727984 4503 1859254 YPR165W RHO1
SGTC_422 cantharidin 155 µM -1.47794903445051 0.0769200086011188 no 3078 0.0697107101278654 4396 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2726 cimetidine 79.27 µM -1.47985775908343 0.0766443947016288 no 3079 0.0694556052911421 4468 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.48272006523286 0.0762324951025567 no 3080 0.0690744006378497 4439 279621
SGTC_1749 st037932 54.2 µM -1.48993825188412 0.0752012462439769 no 3081 0.068120236268018 4492 594497
SGTC_2119 5528445 120.635 µM -1.49019801667363 0.0751643333912969 no 3082 0.0680860888657902 4509 791935
SGTC_1074 carmofur 3.8 µM -1.49131130685274 0.0750062901417569 no 3083 0.0679398908706034 4525 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2957 9076800 11.52 µM -1.49353028252939 0.0746920394024186 no 3084 0.0676492167538774 4470 16459615
SGTC_796 1234-0020 70.7 µM -1.5038601806817 0.0732423336599205 no 3085 0.0663086858504923 4432 46495034
SGTC_1839 st053978 48 µM -1.5110853547056 0.0722412100479394 no 3086 0.0653833527688521 4539 3788398
SGTC_1776 st049249 45.9 µM -1.51386253442141 0.0718592050839353 no 3087 0.0650303540720643 4513 1822314
SGTC_1916 st067606 49.2 µM -1.51661551924061 0.0714820590128106 no 3088 0.0646818924110621 4390 19590279
SGTC_2790 5423970 71.43 µM -1.52043278283716 0.0709616274622498 no 3089 0.0642011202068747 4524 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2853 9015042 58.44 µM -1.52277841215782 0.0706432797111012 no 3090 0.0639070763341825 4442 6457456
SGTC_504 lovastatin 124 µM -1.52284235597944 0.0706346166782849 no 3091 0.0638990751412683 4508 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1460 k062-0059 9.15 µM -1.52456177259268 0.0704019781845032 no 3092 0.0636842191548299 4395 1373085
SGTC_2842 9000675 19.48 µM -1.52499358722809 0.070343645959679 no 3093 0.0636303485802873 4497 2989072
SGTC_3208 9114115 49.47 µM -1.52606747748325 0.0701987392805219 no 3094 0.0634965302796285 4471 650895
SGTC_1466 k213-0079 57.5 µM -1.52670748075668 0.0701124889162384 no 3095 0.0634168831966769 4496 3657981
SGTC_1845 st056753 3.01 µM -1.53063496634361 0.0695849833506603 no 3096 0.0629298174236649 4472 5375839
SGTC_2326 6164455 177.58 µM -1.53117218807981 0.0695130666286673 no 3097 0.0628634212434827 4446 2888790
SGTC_1021 4476-0760 85.3 µM -1.53401938683473 0.0691328733698127 no 3098 0.0625124417160257 4521 746768
SGTC_1684 st024538 14.6195 µM -1.53518693297243 0.0689774321890353 no 3099 0.0623689585638745 4486 6732859
SGTC_689 0833-0039 98 µM -1.53588593596624 0.0688844994718591 no 3100 0.0622831790296772 4467 5374726
SGTC_2665 lovastatin 100 µM -1.53908070563173 0.0684609818820606 no 3101 0.0618922973760706 4554 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_109 0132-0036 33.701 µM -1.54521793638076 0.0676530337802341 no 3102 0.0611467786393642 4417 67274 A color developer.
SGTC_1831 st055328 12 µM -1.55094764476743 0.0669054024956693 no 3103 0.0604571155997385 4506 1103068
SGTC_128 0906-2981 13.371 µM -1.5542744689711 0.0664742496953898 no 3104 0.0600594803982964 4509 6740226
SGTC_339 3091-4833 71.4 µM -1.55464763413616 0.066426022371678 no 3105 0.0600150062528989 4347 3240077
SGTC_2734 clemastine 41.6 µM -1.5568907217276 0.0661366996115307 no 3106 0.0597482163463368 4588 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.55772673761027 0.066029116866078 no 3107 0.0596490197324143 4585 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3245 9134821 49.47 µM -1.5583870314773 0.0659442427916556 no 3108 0.0595707644875656 4526 17014901
SGTC_302 1094-0063 18.9 µM -1.56136544515863 0.0655624482853731 no 3109 0.0592187750482603 4523 5440289
SGTC_455 paf C-16 10 µM -1.56236840017066 0.0654342687859937 no 3110 0.0591006134317743 4497 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1044 1222-0021 1.78 µM -1.56268705015922 0.0653935854414597 no 3111 0.0590631109049459 4448 4306703
SGTC_1036 k216-0215 33.5 µM -1.56304922552952 0.0653473688596176 no 3112 0.059020508461505 4485 622330
SGTC_2465 5809242 33.21 µM -1.56448288080339 0.0651646711768976 no 3113 0.0588521051016022 4601 2731748
SGTC_106 0092-0003 11.579 µM -1.56724544602116 0.064813742015959 no 3114 0.0585286657588889 4450 1072148
SGTC_2354 9060492 162 µM -1.56945030341994 0.0645347129387584 no 3115 0.058271525330806 4537 6471895
SGTC_384 k007-0144 5.16 µM -1.57109190563116 0.0643275716369263 no 3116 0.0580806512472042 4489 6824886
SGTC_1069 diphenylcyclopropenone 8.49 µM -1.57116014125895 0.0643189726996651 no 3117 0.0580727279311939 4559 65057 A dermal irritant. YDR527W RBA50
SGTC_1159 4092-0538 61.2 µM -1.57116465488201 0.0643184039320968 no 3118 0.0580722038528026 4546 717301
SGTC_1418 3966-3099 2.4 µM -1.57449388050347 0.0638999474984729 no 3119 0.057686657585558 4544 740335
SGTC_1708 st033234 31.827 µM -1.57594780670996 0.0637178664194558 no 3120 0.0575189160780084 4598 674664
SGTC_1982 st072467 71.9 µM -1.5767369704237 0.0636192053828701 no 3121 0.0574280299268679 4518 3163533
SGTC_837 0091-0265 12.5 µM -1.5831884674261 0.0628170930832258 no 3122 0.0566892571193518 4537 759367
SGTC_271 rotenone 740 µM -1.5853251909594 0.0625531791961165 no 3123 0.0564462341946708 4570 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2942 9052777 62.25 µM -1.58988121862485 0.0619933359922181 no 3124 0.0559307909443248 4536 6469503
SGTC_385 1494-0393 12.4 µM -1.59028062468678 0.0619444441080403 no 3125 0.0558857819921725 4506 3090647
SGTC_594 1487-1584 10.8 µM -1.59057460922987 0.0619084762572502 no 3126 0.0558526712203774 4509 5013332
SGTC_2951 9072950 58.06 µM -1.60333135626531 0.0603633811833315 no 3127 0.0544307586091018 4464 16488155
SGTC_2709 st078560 56 µM -1.60616388088908 0.0600244354609038 no 3128 0.0541189535381751 4525 17250903
SGTC_1264 0783-0040 158 µM -1.60863234853005 0.0597302705041402 no 3129 0.0538483782557079 4463 2855798
SGTC_3006 9075424 71.4286 µM -1.61421678383681 0.0590689471253937 no 3130 0.0532402063553937 4518 7465181
SGTC_1813 st051246 8.6015 µM -1.6183327444398 0.0585852114590064 no 3131 0.0527954537994044 4514 5291959
SGTC_1373 2887-0003 58.5 µM -1.62168263223971 0.0581938101736541 no 3132 0.0524356597067792 4520 776948
SGTC_9 0092-0002 10.449 µM -1.62323203184989 0.0580134743737957 no 3133 0.052269906409903 4553 759368
SGTC_1751 st044839 27.194 µM -1.62956616793997 0.057280803426108 no 3134 0.0515966098316382 4592 5291326
SGTC_184 1494-0393 24.714 µM -1.63166231972155 0.0570399511262128 no 3135 0.0513753209903991 4544 3090647
SGTC_2043 5101342 149 µM -1.63314161400414 0.0568704574634251 no 3136 0.05121960808763 4585 678451
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.63401765866528 0.0567702697090371 no 3137 0.0511275713905616 4557 688798
SGTC_2962 9082311 13.18 µM -1.63442894592288 0.0567232813349506 no 3138 0.0510844072327042 4535 16459453
SGTC_926 2268-1401 59.4 µM -1.63806204684674 0.0563095395680382 no 3139 0.0507043755827355 4537 2931578
SGTC_304 1310-0298 97 µM -1.6387136334288 0.0562355883522756 no 3140 0.0506364566774981 4309 1550234
SGTC_1958 st076513 41.9 µM -1.63946356091774 0.0561505708273549 no 3141 0.050558376804772 4497 732122 YGL099W LSG1
SGTC_2379 9035213 200 µM -1.63950348089114 0.0561460480360552 no 3142 0.0505542231644141 4568 646551
SGTC_258 haloperidol 50.781 µM -1.64078828988023 0.056000637083988 no 3143 0.0504206849536255 4547 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2266 7929956 200 µM -1.64401130643579 0.0556371725107884 no 3144 0.0500869334644984 4514 2967153
SGTC_2912 7964298 10.93 µM -1.64647441119152 0.0553606615564897 no 3145 0.0498330620758201 4551 2975850
SGTC_1471 k673-0312 37 µM -1.64650017462712 0.0553577750689923 no 3146 0.0498304120814222 4548 24099884
SGTC_424 splitomicin 100 mM -1.6482085367318 0.0551666384273942 no 3147 0.0496549428258614 4550 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3131 9127911 49.47 µM -1.6500284419204 0.0549635958947764 no 3148 0.0494685594910531 4561 45595681
SGTC_1692 fluoroquinolonic acid 71 µM -1.65268640183655 0.0546681151673933 no 3149 0.0491973516504395 4587 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2245 6637752 200 µM -1.65307487376877 0.0546250348170843 no 3150 0.0491578131379381 4584 681890
SGTC_3035 9091303 49.47 µM -1.65390896128246 0.0545326277555082 no 3151 0.0490730057987795 4621 25237002
SGTC_2141 5621638 7.665 µM -1.65398026139863 0.0545247342824535 no 3152 0.0490657616575549 4579 2856238
SGTC_1135 dihydrocapsaicin 536.708 nM -1.65534634133295 0.0543736731314908 no 3153 0.0489271318899776 4485 107982 A Capsaicinoid.
SGTC_2777 climbazole 1.536 µM -1.65544743375818 0.0543625074985089 no 3154 0.0489168854816249 4370 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1887 st057648 70.8 µM -1.65971997275893 0.0538922627490203 no 3155 0.0484853997372386 4555 688672
SGTC_2568 diosmetin 100 µM -1.65989864765714 0.0538726677895795 no 3156 0.0484674217884536 4576 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2264 7948757 110.76 µM -1.66196414096552 0.0536465581149776 no 3157 0.0482599823159706 4542 2971411
SGTC_1161 k007-0610 110 µM -1.66286379154334 0.0535483086274599 no 3158 0.0481698518836004 4512 5843850
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.66759799853872 0.0530336397929084 no 3159 0.0476977779227606 4565 688803
SGTC_754 3474-0146 171 µM -1.6698793155007 0.0527870359837184 no 3160 0.0474716217769914 4556 24762078
SGTC_29 0299-0004 12.984 µM -1.6779943452963 0.0519171910082783 no 3161 0.0466741014625475 4509 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2760 etidronate 98.04 µM -1.67932559947385 0.051775588401543 no 3162 0.0465443022526582 4538 3305 A chelator and antioxidant.
SGTC_3174 9107204 49.47 µM -1.67982829287285 0.0517221979108203 no 3163 0.0464953643321519 4572 3938802
SGTC_1056 3448-1962 115 µM -1.68342081141148 0.0513419135247983 no 3164 0.0461468286332361 4540 715507
SGTC_1429 4049-0205 9.46 µM -1.68950852050471 0.0507025829489092 no 3165 0.0455610102036162 4635 22774478
SGTC_1107 amlodipine 47 µM -1.69634034827985 0.0499926724722282 no 3166 0.0449107217417222 4158 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_329 k048-0121 21.3 µM -1.70649589616879 0.0489520602558875 no 3167 0.0439578948693532 4598 6832902
SGTC_1734 st037168 69.4 µM -1.71179753648615 0.048415731375091 no 3168 0.0434669931157397 4590 708907
SGTC_2222 6885208 172.143 µM -1.71392153010185 0.0482021851048919 no 3169 0.0432715691627508 4624 609514
SGTC_348 k064-0012 10.7 µM -1.71955349342399 0.0476395946104816 no 3170 0.0427568180109453 4560 5066323
SGTC_1378 2093-0007 380 nM -1.71965133593759 0.0476298675599984 no 3171 0.0427479193178984 4602 3618014
SGTC_66 0109-0187 42.4 µM -1.72068374513225 0.0475273271275354 no 3172 0.0426541137940475 4444 759417
SGTC_1349 flufenamic acid 69 µM -1.72470646762625 0.0471294701766603 no 3173 0.0422901924456504 4544 3371 A non-steroidal anti-inflammatory.
SGTC_344 k064-0035 6.43 µM -1.73180771316208 0.0464336603135588 no 3174 0.0416539021929016 4549 5088750
SGTC_1051 3253-3903 78 µM -1.73407866041268 0.046212891728537 no 3175 0.0414520636334232 4597 5509239
SGTC_2818 7996756 12.99 µM -1.73581985629148 0.0460441941157032 no 3176 0.0412978460169401 4624 2241621
SGTC_966 1300-0360 30.2 µM -1.74843971459462 0.0448362437746076 no 3177 0.0401939580040072 4596 70588
SGTC_1682 st012968 530 nM -1.75241310962394 0.0444612430675748 no 3178 0.039851399419824 4576 24207270
SGTC_1752 st044819 83.042 µM -1.75902317656629 0.0438430011865303 no 3179 0.0392867860366374 4553 441209 YML126C ERG13
SGTC_284 0988-0104 32.6 µM -1.75925526109238 0.0438214208958477 no 3180 0.0392670809320602 4594 4666532
SGTC_1617 st002906 78 µM -1.75995619515121 0.0437562968262241 no 3181 0.0392076170463264 4599 5150859
SGTC_1057 3448-5381 134 µM -1.76067096309999 0.043689967876559 no 3182 0.0391470550540651 4605 5497911
SGTC_2260 7964312 200 µM -1.77311141338496 0.042548461347487 no 3183 0.0381051235590203 4627 231951
SGTC_1187 1391-0724 117 µM -1.77508891570176 0.0423692519997072 no 3184 0.0379416034471748 4652 6997986
SGTC_2792 7535235 81.82 µM -1.78046244425326 0.0418853631669254 no 3185 0.0375001551351633 4583 1281891
SGTC_2333 9017922 200 µM -1.78064267981621 0.0418692107506617 no 3186 0.0374854213607872 4596 3163164
SGTC_2636 apigenin dimethyl ether 100 µM -1.78500344859835 0.0414799406670291 no 3187 0.0371303787542356 4577 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2001 4023502 57.655 µM -1.79380524577978 0.0407031697682257 no 3188 0.0364221296878016 4602 108941 YCR052W RSC6
SGTC_2285 7945142 200 µM -1.80103142908662 0.0400743097142349 no 3189 0.0358489631826469 4630 2970608
SGTC_2161 5662504 8.5105 µM -1.80183942253777 0.0400044872873448 no 3190 0.0357853366422804 4623 2859334
SGTC_2907 7721985 69.9 µM -1.80276765462235 0.0399243965414897 no 3191 0.0357123559937355 4617 3267881
SGTC_2765 myclobutanil 7.74 µM -1.80352589122576 0.0398590702821162 no 3192 0.0356528315018005 4630 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_913 3487-1245 167 µM -1.81070677666248 0.0392446956995313 no 3193 0.0350931266542812 4567 4016153
SGTC_2261 9010538 184.68 µM -1.81237628319373 0.0391029676116954 no 3194 0.034964037440384 4608 6457250
SGTC_3318 9139014 38.6185 µM -1.81521685810376 0.0388627827103186 no 3195 0.0347452949968975 4620 16643984
SGTC_209 4077-0173 175.592 µM -1.81632864487457 0.038769103315522 no 3196 0.0346599868510725 4613 15993494
SGTC_1788 fluconazole 20 µM -1.82046055997237 0.0384225581809201 no 3197 0.0343444485965563 4622 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1554 st069299 38.7 µM -1.82420622369398 0.0381105940372036 no 3198 0.0340604505280681 4590 24207999
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.84187423665602 0.0366668234315899 no 3199 0.0327467739599712 4635 6708561
SGTC_444 curcumin 90.4 µM -1.84453963477416 0.0364529510916926 no 3200 0.0325522675758737 4543 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1387 3342-1166 1.8 µM -1.84481460246249 0.0364309458100762 no 3201 0.0325322562534977 4657 3418228
SGTC_2224 6650123 117.647 µM -1.84571919867436 0.0363586289316142 no 3202 0.0324664940504821 4694 2908370
SGTC_1740 st038286 13.222 µM -1.850690450723 0.0359633023500212 no 3203 0.032107049319755 4630 716786
SGTC_1662 st014054 52 µM -1.85403257275964 0.0356995127902016 no 3204 0.0318672500403121 4700 2838777
SGTC_909 3448-9333 149 µM -1.85415270874455 0.0356900602096959 no 3205 0.0318586578299864 4582 3344074
SGTC_892 0929-0076 29 µM -1.85727825152813 0.0354448552318452 no 3206 0.0316357884794573 4644 5751038
SGTC_849 0386-0493 241 µM -1.85749627562046 0.0354278024802176 no 3207 0.0316202902882603 4660 726119
SGTC_1091 telmisartan 47.6 µM -1.86543179325795 0.0348116903319704 no 3208 0.0310604521940306 4665 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2580 diallyl disulphide 81.36 µM -1.86931598194439 0.0345133448708601 no 3209 0.0307894329523544 4614 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2984 9022109 38.96 µM -1.87139955696269 0.0343541725802252 no 3210 0.0306448601386164 4645 6459207
SGTC_1852 st056254 31.4 µM -1.87272309209422 0.0342533763282521 no 3211 0.0305533164422751 4629 442583
SGTC_2332 7982454 138.89 µM -1.87814480837708 0.0338430098890678 no 3212 0.0301806789782395 4553 2981748
SGTC_2428 5615643 7.78 µM -1.88494660392337 0.0333339145536622 no 3213 0.0297185236011554 4655 2253075
SGTC_943 3253-1379 105 µM -1.88568806010124 0.0332788018581084 no 3214 0.0296685014032678 4621 668464
SGTC_2558 carylophyllene oxide 100 µM -1.88988730351072 0.0329680850291524 no 3215 0.0293865169801848 4716 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_98 0074-0023 107.663 µM -1.90825464374197 0.0316369940001314 no 3216 0.0281791560568107 4662 3563821
SGTC_244 nsc-207895 1.295 µM -1.91472205035082 0.0311790007965637 no 3217 0.0277639799785321 4525 42640
SGTC_980 1473-0395 201 µM -1.92428533874049 0.0305118330685939 no 3218 0.0271594136428303 4600 768876
SGTC_236 1509-0011 5.31 µM -1.92817735747174 0.0302437193363838 no 3219 0.0269165347755962 4664 3107280
SGTC_157 1348-1695 65.819 µM -1.92961905076665 0.030144900759508 no 3220 0.0268270282832824 4587 5380510
SGTC_2800 7887935 81.82 µM -1.93061404042205 0.0300768570046199 no 3221 0.0267654001189061 4645 2961002
SGTC_666 0272-0154 136 µM -1.93604177946031 0.0297079119639028 no 3222 0.0264312920946564 4665 6870312
SGTC_1723 st034307 2.5525 µM -1.94540251241641 0.0290804513308731 no 3223 0.0258632763052451 4645 867466
SGTC_2353 9059630 146.67 µM -1.95026247409652 0.0287590496165775 no 3224 0.0255724214574989 4689 4779114
SGTC_2811 7967822 32.47 µM -1.95471238443471 0.0284673611684347 no 3225 0.0253085137543915 4660 2232244
SGTC_2681 menadione 3.18 µM -1.95838285021618 0.0282286210071091 no 3226 0.0250925528023355 4695 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_266 formosanin C 406 nM -1.95914120300644 0.0281795033571806 no 3227 0.025048126313089 4528 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2357 9067248 200 µM -1.96213469051272 0.0279863127825123 no 3228 0.0248734025331986 4629 9150235
SGTC_1603 st002045 67.8 µM -1.96356103555994 0.0278946495555065 no 3229 0.0247905098844388 4674 5887985
SGTC_2137 5261020 140 µM -1.96700772203458 0.0276741821955965 no 3230 0.0245911602689079 4655 763655
SGTC_2719 novobiocin 32.65 µM -1.96775169429327 0.0276267850490016 no 3231 0.0245483073474094 4686 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2810 7959871 45.46 µM -1.97511193219639 0.0271615130160919 no 3232 0.0241277235162679 4614 2974535
SGTC_783 0848-0141 92.7 µM -1.97936788006416 0.0268954722697441 no 3233 0.0238873010573912 4640 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_246 cycloheximide 667 µM -1.98611611434498 0.0264780991684479 no 3234 0.0235102161892415 4667 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2872 9044037 25.97 µM -1.98765431218312 0.0263837240565076 no 3235 0.0234249675539923 4721 6465195
SGTC_743 1275-0778 158 µM -1.98897199246068 0.0263031023795512 no 3236 0.0233521472229535 4665 2849257 YMR203W TOM40
SGTC_1003 4049-0218 100 µM -1.99049876128862 0.0262099453657811 no 3237 0.0232680101555928 4680 295161
SGTC_927 2425-1185 123 µM -1.99065019769359 0.0262007204094953 no 3238 0.0232596787360244 4649 730375
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.99114638507824 0.0261705134924468 no 3239 0.023232398100177 4692 5024745
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.99248313872814 0.0260892794181386 no 3240 0.0231590366959677 4670 97141
SGTC_107 0358-0022 2.6945 µM -1.99477044054968 0.0259507700080662 no 3241 0.0230339613422972 4708 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_954 1189-0853 2.85 µM -1.99484052273092 0.0259465358570299 no 3242 0.023030138074185 4634 2828194
SGTC_1983 st071813 46.9 µM -2.00061534066965 0.0255996196170867 no 3243 0.022716929547764 4720 11838595
SGTC_2544 sphondin 68.51 µM -2.00170363766349 0.0255346781214439 no 3244 0.022658307473066 4641 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1572 epiandrosterone 68.9 µM -2.00192866542146 0.0255212673587005 no 3245 0.0226462020773007 4659 441302 A steroid.
SGTC_2095 5432005 200 µM -2.01182299742537 0.0249374088228264 no 3246 0.0221192993979971 4707 783734
SGTC_3150 9097574 49.47 µM -2.02215136682201 0.0243399275473102 no 3247 0.0215803583692124 4701 17217476
SGTC_2823 7987624 58.44 µM -2.02417499490831 0.0242242829637721 no 3248 0.0214760747152815 4631 2239440
SGTC_1777 st045864 34.765 µM -2.02506580595426 0.0241735221225561 no 3249 0.0214303037464564 4707 4691462
SGTC_2621 lithochol-11-enic acid 100 µM -2.03061052025864 0.0238595740384263 no 3250 0.0211472598431758 4639 6708711
SGTC_893 0958-0369 48.9 µM -2.03099325968538 0.0238380299313623 no 3251 0.021127839177553 4554 6819948
SGTC_3023 9089636 49.47 µM -2.04909029652275 0.0228378680757323 no 3252 0.0202266430820789 4743 17249241
SGTC_1015 4130-4525 82 µM -2.05011201155355 0.0227824718869494 no 3253 0.0201767507633436 4684 1363237
SGTC_1709 st033179 39.1045 µM -2.06933160105754 0.0217613234312431 no 3254 0.0192574900855651 4702 573381
SGTC_2302 7771753 200 µM -2.07789352205833 0.0213190267477669 no 3255 0.0188595836551484 4664 2203047
SGTC_733 4069-0007 56.1 µM -2.08156960606985 0.0211314712574641 no 3256 0.018690900018662 4692 5717425 YNL287W SEC21
SGTC_1896 st058441 89 µM -2.08582553426902 0.020916077257705 no 3257 0.0184972147786462 4710 688759
SGTC_2757 clomiphene 4.22 µM -2.09044157804752 0.0206845614800953 no 3258 0.018289075624111 4676 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1873 rapamycin 2 nM -2.09324785160252 0.0205448775471929 no 3259 0.0181635175787784 4686 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_405 ebelactone b 50 µM -2.10327138967603 0.0200524573932964 no 3260 0.0177210264540907 4689 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_719 2810-4230 27.3 µM -2.10428218436257 0.0200033610403203 no 3261 0.0176769195931761 4725 721079
SGTC_2980 9014342 25.29 µM -2.1054354863782 0.0199474674083938 no 3262 0.0176267087640321 4693 2996599
SGTC_660 4031-1742 102 µM -2.12447465224617 0.0190437325304538 no 3263 0.0168152367121328 4615 6738706
SGTC_2162 5663267 200 µM -2.12884430894809 0.0188413021038917 no 3264 0.0166335718226569 4714 6456493
SGTC_1978 st071761 42 µM -2.12989554531494 0.0187928762319072 no 3265 0.0165901190036503 4724 5147680
SGTC_2459 5811157 9.22 µM -2.14765165583241 0.0179907954997458 no 3266 0.0158707192754697 4682 2870684 YBR192W RIM2
SGTC_130 0136-0219 337.655 µM -2.14766945319092 0.0179900064332795 no 3267 0.0158700118418052 4654 234244
SGTC_1353 1498-1206 8.11 µM -2.1516307606542 0.0178151099622801 no 3268 0.0157132237028765 4722 6756808
SGTC_2337 9009472 200 µM -2.15209818172824 0.0177945687523135 no 3269 0.0156948111683388 4663 5742383
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -2.16141376989008 0.0173893819600215 no 3270 0.0153316956837246 4744 66535 A nucleotide analog.
SGTC_1892 st058411 7.36 µM -2.20120274630389 0.0157462625328791 no 3271 0.0138608369878301 4713 3934738
SGTC_550 4123-0385 25.7 µM -2.21495494808101 0.0152102071322459 no 3272 0.0133815784827516 4731 5731123
SGTC_2409 alverine citrate 63.97 µM -2.21800737634872 0.0150933739158521 no 3273 0.0132771647380739 4684 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2540 epiandrosterone 100 µM -2.25010207041028 0.0139108993281214 no 3274 0.0122212333477467 4738 441302 A steroid.
SGTC_2732 terfenadine 20 µM -2.25603213111315 0.0137013896531724 no 3275 0.0120343094653895 4769 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_3080 9117754 49.47 µM -2.26333460539514 0.0134471374703439 no 3276 0.0118075353035703 4724 9550191
SGTC_453 enantio-paf c16 10 µM -2.26686261044396 0.0133257683615867 no 3277 0.0116993099559402 4285 13871343 A lipid and platelet activating factor
SGTC_3283 9109332 35.8195 µM -2.30120521506669 0.0121929278037782 no 3278 0.0106900171317393 4628 17027281
SGTC_2294 7971431 200 µM -2.30188135980168 0.0121714888862157 no 3279 0.0106709318403353 4727 5741572
SGTC_534 k292-0788 63.4 µM -2.30325086268104 0.0121281653438455 no 3280 0.0106323662843605 4755 4146317
SGTC_520 3584-0023 682 µM -2.31788747735988 0.0116734292233191 no 3281 0.0102277186001519 4708 1340790
SGTC_526 4469-0568 170 µM -2.34649944250146 0.0108270969023856 no 3282 0.00947534728036378 4728 2901964
SGTC_3290 9121031 71.43 µM -2.34761703131849 0.0107951518872327 no 3283 0.00944696828364603 4735 17014854
SGTC_982 1491-0518 27.5 µM -2.347636376261 0.0107945996570702 no 3284 0.00944647771157992 4739 3091256
SGTC_141 0443-0274 32.331 µM -2.34896623244239 0.0107566958406277 no 3285 0.00941280699981051 4698 1627241
SGTC_2381 9035592 200 µM -2.35330121412348 0.0106339427402417 no 3286 0.00930377703149619 4747 4749657
SGTC_1694 st024011 44.9 µM -2.35379769951283 0.0106199620037258 no 3287 0.00929136063314855 4770 2787533
SGTC_1121 fusaric acid 630.51 nM -2.35950982208423 0.0104602601758114 no 3288 0.00914954822058431 4732 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_277 nystatin 15.5 µM -2.36923478050916 0.0101931780625611 no 3289 0.00891246712479908 4751 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1550 gossypolone 36.6 µM -2.37239414548693 0.0101077002685383 no 3290 0.00883661322572242 4758 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1123 mangostin 811.285 nM -2.40097907522891 0.00936233024160287 no 3291 0.00817563573861456 4745 5281650 An antioxidant.
SGTC_2116 5511452 16.8835 µM -2.40486149863103 0.00926489666831744 no 3292 0.00808929803970546 4763 870744
SGTC_2809 7964133 12.99 µM -2.42483561144947 0.00877752421147073 no 3293 0.00765766000108391 4728 1253665
SGTC_2972 9093619 59.92 µM -2.42679925960049 0.00873084645766155 no 3294 0.00761634083508832 4725 25236256
SGTC_2023 5144124 124 µM -2.47105434519209 0.00773505217698224 no 3295 0.00673576723028713 4741 2830192
SGTC_2801 7907800 81.82 µM -2.48290674423835 0.00748593846288517 no 3296 0.0065157599158083 4729 6620925
SGTC_1459 k035-0031 35.7 µM -2.48634037857579 0.00741510331456209 no 3297 0.00645322272454211 4644 3877128 YMR208W ERG12
SGTC_1163 k060-0048 49.9 µM -2.48802102212944 0.00738064779405327 no 3298 0.0064228069849023 4763 6809982
SGTC_1879 gemcitabine 100 µM -2.49042396729993 0.00733162920299417 no 3299 0.00637953961273988 4739 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2597 laccaic acid a 100 µM -2.50988678594793 0.00694506196339297 no 3300 0.0060384937123284 4735 5491415 A textile dye.
SGTC_3191 9110352 49.47 µM -2.51595308711344 0.00682830952075429 no 3301 0.00593554914650018 4737 17122424
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -2.52007015656211 0.00675006297500911 no 3302 0.00586657230174482 4778 16486 A toxic proline analog.
SGTC_2168 5727979 200 µM -2.52264307335382 0.00670156690439039 no 3303 0.00582382787461607 4738 695210
SGTC_1926 methyl fluorone black 53.6 µM -2.52377547111438 0.00668032047419286 no 3304 0.00580510283184772 4505 72721 Reacts with homocysteine.
SGTC_2276 7947513 42.08 µM -2.53413730975381 0.00648865643183904 no 3305 0.00563622756655283 4721 2105100
SGTC_134 0269-0018 6.916 µM -2.54555117717387 0.00628317777299168 no 3306 0.00545526847370842 4735 4378915
SGTC_955 1216-0110 33 µM -2.59154795288403 0.00551232798123739 no 3307 0.00477726124745752 4742 3619719
SGTC_2144 5628481 200 µM -2.5958928836068 0.00544404798357112 no 3308 0.00471727362423079 4781 2818399
SGTC_2291 7917025 104.35 µM -2.60872722164703 0.0052467270400164 no 3309 0.00454398270540976 4721 2964612
SGTC_2356 9061756 188.97 µM -2.61570571817537 0.00514212883656279 no 3310 0.0044521632124741 4770 20104043
SGTC_516 3992-2719 87.3 µM -2.62994705664005 0.00493441150294645 no 3311 0.00426990832396681 4727 5350887 YDR037W KRS1
SGTC_3351 9150312 21.596 µM -2.63477966744202 0.0048656435154115 no 3312 0.00420959572976684 4748 4904905
SGTC_1696 st025591 34.7925 µM -2.6449102692068 0.00472425083697686 no 3313 0.00408562911896651 4768 2787147
SGTC_3294 9122953 26.2835 µM -2.65037325379595 0.0046495350570726 no 3314 0.00402014445095473 4754 16459826
SGTC_525 k781-2675 26.7 µM -2.66013854895067 0.00451860074517089 no 3315 0.00390542568443037 4741 3651118 YDL195W SEC31
SGTC_1465 k213-0056 144 µM -2.66442356392767 0.00446219340275997 no 3316 0.00385601951820621 4732 24048857 YMR208W ERG12
SGTC_1052 3253-3998 198 µM -2.67129716257656 0.00437302311043712 no 3317 0.00377793614683794 4756 5450317
SGTC_263 alizarin 107.927 µM -2.70213353653652 0.00399227652751915 no 3318 0.00344480429029702 4776 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2120 5538279 151.968 µM -2.70795801974758 0.00392378749056982 no 3319 0.00338492925646161 4784 2058197
SGTC_2762 leflunomide 42.06 µM -2.71805083036457 0.00380759654462479 no 3320 0.00328338745137841 4775 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_296 1222-0039 74.9 µM -2.75144185656382 0.00344485243348828 no 3321 0.00296667758694413 4796 5984176
SGTC_1567 st069303 68.4 µM -2.75838420525463 0.00337345185495744 no 3322 0.00290439404478653 4764 5581319
SGTC_633 0437-0093 97.7 µM -2.75903549461857 0.00336682220806901 no 3323 0.00289861189470188 4764 2831118
SGTC_1986 st071812 45 µM -2.79131630039426 0.0030525475036592 no 3324 0.00262470729706875 4761 11838594
SGTC_578 3460-0051 92 µM -2.80252915362039 0.00294972809945465 no 3325 0.00253518167656676 4792 2876744
SGTC_415 dibenzyl ketone 100 µM -2.8091239100393 0.00289072368695781 no 3326 0.00248382613810215 4778 7593
SGTC_3288 9119690 36.221 µM -2.82020980214131 0.00279393059395972 no 3327 0.00239961301584622 4776 17595618 YKL019W RAM2
SGTC_1126 isoteolin 1.0172 µM -2.85057714741892 0.00254358359460416 no 3328 0.00218199811605952 4769 133323
SGTC_720 r052-1644 49.9 µM -2.91495554138905 0.0020786784476898 no 3329 0.0017786960771389 4789 1422863 YOR257W CDC31
SGTC_586 0957-0265 8.15 µM -2.92222848367709 0.0020313246216391 no 3330 0.00173768244207803 4762 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1980 st071811 45.7 µM -2.93545353790697 0.00194771863438601 no 3331 0.00166530242776945 4794 4974850
SGTC_1363 1636-0063 10.4 µM -2.95453230924581 0.00183260748439702 no 3332 0.00156571681311399 4790 6072185
SGTC_750 4073-0104 132 µM -2.96244791720391 0.00178669177069249 no 3333 0.00152601719327675 4643 22330957
SGTC_2425 5628681 7.85 µM -2.96464111178718 0.00177415628256923 no 3334 0.00151518113333822 4790 5714958
SGTC_1707 st032323 6.317 µM -3.02219695428692 0.001472488684397 no 3335 0.0012547360598274 4702 3132057 YMR211W DML1
SGTC_2297 7971671 152.32 µM -3.02361708998183 0.00146567576257672 no 3336 0.00124886176264559 4781 909016
SGTC_1732 st034308 51.822 µM -3.06891979614149 0.00126287425400043 no 3337 0.00107417129375387 4757 830119
SGTC_3143 9086658 49.47 µM -3.08736802393641 0.00118790997506325 no 3338 0.0010096870914823 4753 25236626
SGTC_1575 cyproterone acetate 48 µM -3.10066754859501 0.00113641910309316 no 3339 0.000965424707786823 4785 9880 An androgen receptor antagonist and liver toxin.
SGTC_912 3474-0017 2.18 µM -3.10079572445279 0.00113593295728515 no 3340 0.000965006929189525 4790 3360550
SGTC_58 0957-0393 9 µM -3.13832304027068 0.00100152035843726 no 3341 0.000849587495758541 4484 6997992
SGTC_531 3788-1495 174 µM -3.13956099316806 0.000997345930852625 yes 3342 0.000846005937601537 4785 2896655
SGTC_180 1486-1293 102.781 µM -3.15761555840166 0.000938252685882799 yes 3343 0.000795325889009088 4776 4140536
SGTC_582 0987-0078 156 µM -3.21192291121268 0.000779347768313505 yes 3344 0.000659248748583762 4803 1625765
SGTC_2253 7938677 135.83 µM -3.21225968453491 0.000778444761182016 yes 3345 0.000658476380208253 4799 2301972
SGTC_2273 7815444 169.05 µM -3.22512547537361 0.000744660096958083 yes 3346 0.000629587341080873 4784 2824616
SGTC_560 2332-1943 155 µM -3.29989523822223 0.000573635057551747 yes 3347 0.000483604632965089 4801 21177716
SGTC_1745 st081495 74 µM -3.40622364758557 0.000392237014462606 yes 3348 0.00032934098573944 4749 13842402 YBL026W LSM2
SGTC_1591 genipin 88.4 µM -3.50550295185424 0.000272411177289347 yes 3349 0.000227872723824717 4798 442424 A DNA cross-linking agent.
SGTC_1601 4'-hydroxyflavanone 55.5 µM -3.64445215220225 0.000161004438611774 yes 3350 0.00013398098949384 4804 165506
SGTC_543 3844-1095 191 µM -3.6525397693884 0.000156062886553312 yes 3351 0.000129829683173172 4800 4230703
SGTC_513 4245-1575 41.7 µM -4.07525944082144 2.80568221749184e-05 yes 3352 2.29815373571395e-05 4773 719745
SGTC_2679 rapamycin 1 nM -4.13765636029257 2.14660445560287e-05 yes 3353 1.7543566824752e-05 4758 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_737 1950-0117 57.9 µM -4.23065826612468 1.43027346657651e-05 yes 3354 1.1650421690889e-05 4807 5393513
SGTC_138 0850-0259 40.9225 µM -4.65696133671126 1.99938901443896e-06 yes 3355 1.60455341081064e-06 4800 6813004
SGTC_1844 rapamycin 4 nM -5.04462810242965 2.86822284467228e-07 yes 3356 2.27202156757875e-07 4778 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2