SGTCid condition conc unit ZWF1|YNL241C.score ZWF1|YNL241C.strain.pval ZWF1|YNL241C.strain.significant ZWF1|YNL241C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2681 menadione 3.18 µM 14.0472697946189 1.86406898053292e-45 yes 1 4.00307633191588e-45 3 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_58 0957-0393 9 µM 11.9573636537524 1.56187804596166e-33 yes 2 2.97092598087176e-33 53 6997992
SGTC_2022 5136654 200 µM 8.85271903111236 2.6717923467232e-19 yes 3 4.27062460788149e-19 2 1713771
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 8.43544901104013 1.05585427335694e-17 yes 4 1.64966822949585e-17 11 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_394 menadione 8.33 µM 8.37447840172787 1.7810178998137e-17 yes 5 2.77344968014752e-17 5 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_29 0299-0004 12.984 µM 7.97725555456857 4.90871104107683e-16 yes 6 7.48114158470505e-16 7 16871 A napthoquinone isolated from Swertia calycina.
SGTC_34 0469-0683 81.75 µM 7.47023712462468 2.69887241918766e-14 yes 7 4.00252182007037e-14 4 3690923
SGTC_1556 plumbagin 1.48 µM 7.45631863286311 3.00194573806136e-14 yes 8 4.44867137051296e-14 10 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_451 chloral hydrate 100 µM 7.24324660275958 1.49497422342085e-13 yes 9 2.19034661674713e-13 9 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_318 1488-0629 67.2 µM 6.72890068580407 5.99554466416091e-12 yes 10 8.5474839955375e-12 9 3662576
SGTC_2325 6158266 200 µM 6.51517692858917 2.57525836762692e-11 yes 11 3.63020143093064e-11 3 3623240
SGTC_2002 4023503 131 µM 6.05392002711558 5.13691559542098e-10 yes 12 7.06814052464662e-10 7 4736863 YCR052W RSC6
SGTC_2982 9019404 25.97 µM 5.28012012290768 4.8831229539389e-08 yes 13 6.45496101141931e-08 11 22333232
SGTC_1689 st020265 53.493 µM 5.247017220578 5.85692350575625e-08 yes 14 7.72907275350791e-08 4 5758320 YPR016C TIF6
SGTC_513 4245-1575 41.7 µM 4.89321477040311 3.82724288335996e-07 yes 15 4.96010235376602e-07 77 719745
SGTC_2040 5100729 123 µM 4.86786094486149 4.35796187071097e-07 yes 16 5.64063307260019e-07 25 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2582 agaric acid 100 µM 4.53369566226073 2.27723262160084e-06 yes 17 2.89802623858427e-06 251 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1739 st037196 92.5 µM 4.528113849727 2.33886748573775e-06 yes 18 2.9756258153921e-06 12 612214
SGTC_740 k014-0057 261 µM 4.46490283349753 3.15820402368387e-06 yes 19 4.00525488117412e-06 15 4012779
SGTC_3049 9092223 49.47 µM 4.28963292159751 7.11833317808275e-06 yes 20 8.94843376619242e-06 15 8623917
SGTC_1720 st037298 9.481 µM 4.26719695045132 7.8819244883979e-06 yes 21 9.89721977459165e-06 29 597396
SGTC_371 0195-0006 7.36 µM 4.19789701386926 1.07646386077594e-05 yes 22 1.34702544184887e-05 15 3928593
SGTC_2307 7538926 6.34 µM 4.15979738553406 1.27517541606135e-05 yes 23 1.59265018508731e-05 35 96582
SGTC_2001 4023502 57.655 µM 4.13666166840193 1.41237639715889e-05 yes 24 1.76197551384003e-05 12 108941 YCR052W RSC6
SGTC_368 fentichlor 4.58 µM 4.12828124283502 1.46545152241299e-05 yes 25 1.82742459867062e-05 22 7329 A pesticide.
SGTC_2068 5226020 147 µM 4.12821127735407 1.46590250763482e-05 yes 26 1.82798060536483e-05 29 1810509
SGTC_3061 glucosamine 200 µM 4.0714762897655 1.87843922939627e-05 yes 27 2.33580590697368e-05 9 91431 and experimental redox chemotherapeutic
SGTC_1275 0867-0008 21.1 µM 4.06092795002453 1.96640146822056e-05 yes 28 2.44390275705401e-05 12 3422836
SGTC_470 aa-861 153 µM 3.99664709197218 2.59293219864958e-05 yes 29 3.21229839561741e-05 52 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2012 4023501 200 µM 3.98686356157995 2.70347866710693e-05 yes 30 3.34762506066648e-05 29 3477460
SGTC_964 1287-0107 19.4 µM 3.96498398979001 2.96707609470513e-05 yes 31 3.6700436749137e-05 41 51516812 YPR165W RHO1
SGTC_1716 st033144 30.6155 µM 3.92779787109845 3.47173394091101e-05 yes 32 4.28636058206039e-05 23 674617
SGTC_208 k072-0098 12.366 µM 3.83613808012253 5.08453411529868e-05 yes 33 6.24920777184749e-05 48 5948901
SGTC_701 4424-0219 185 µM 3.78971455684503 6.14966219784226e-05 yes 34 7.54102467765605e-05 20 2911779
SGTC_626 0214-0009 33 µM 3.73694164738381 7.61495994754086e-05 yes 35 9.31360651334117e-05 26 3437874
SGTC_754 3474-0146 171 µM 3.67248298188044 9.85094895468528e-05 yes 36 0.000120102576108565 33 24762078
SGTC_975 1335-0046 28.5 µM 3.63098666531176 0.000116025109211941 yes 37 0.000141169886836283 51 16486740
SGTC_311 1315-0136 58 µM 3.53777093175901 0.000166581318781131 yes 38 0.000201759982629009 19 6759207
SGTC_2259 7964009 200 µM 3.52012995640519 0.000178217593825267 yes 39 0.000215667701177741 45 313134
SGTC_362 0310-0100 9.03 µM 3.49326279122775 0.000197408535174983 yes 40 0.000238578346695487 49 790235
SGTC_939 1165-0479 45.3 µM 3.41677960261609 0.000263137563207471 yes 41 0.000316832783270109 56 1377347
SGTC_106 0092-0003 11.579 µM 3.40279347416936 0.000277171340132511 yes 42 0.000333503392627852 26 1072148
SGTC_2823 7987624 58.44 µM 3.39773603195326 0.000282415400205054 yes 43 0.000339729732570415 56 2239440
SGTC_2126 5251174 33.877 µM 3.36477438105934 0.000318921936378745 yes 44 0.000383031366645216 61 790722
SGTC_1358 1509-0022 2.48 µM 3.35786368973403 0.000327112522254178 yes 45 0.000392736685682477 29 3258434
SGTC_1232 0279-0259 161 µM 3.34851174441486 0.000338508205655311 yes 46 0.000406234186172681 43 1560000
SGTC_2398 5228213 48.84 µM 3.34272266879289 0.000345746206284344 yes 47 0.000414803831623967 74 80771 YMR134W ERG29
SGTC_2985 9022375 71.43 µM 3.32712629671034 0.000365968152793789 yes 48 0.000438732972613086 53 4939335
SGTC_2781 5567276 71.43 µM 3.29260227633485 0.000414700294562528 yes 49 0.000496323931776734 90 2853274
SGTC_815 1582-0027 36.9 µM 3.28183074771432 0.000431095617030594 yes 50 0.000515677452763921 64 3128206
SGTC_1635 st007035 42.4 µM 3.269343154821 0.000450854444774196 yes 51 0.000538987409729677 266 3716403
SGTC_2158 5657123 3.6195 µM 3.26238629751578 0.000462222935205594 yes 52 0.000552392411028584 15 2858827
SGTC_23 0213-0011 39.996 µM 3.23738031203183 0.000505315774827274 yes 53 0.000603162649007931 45 627608
SGTC_3337 9144342 33.5465 µM 3.21599687468267 0.000545084792626475 yes 54 0.00064996123890657 48 17682949
SGTC_289 k017-0060 526 µM 3.19323118163369 0.000590591742197855 yes 55 0.000703451311849546 11 5512909
SGTC_100 0086-0128 49.5915 µM 3.18641913680924 0.000604875969319709 yes 56 0.00072022874226053 93 93297
SGTC_2986 9022445 71.43 µM 3.18554791135092 0.000606725690481127 yes 57 0.000722400891350832 37 6459286
SGTC_444 curcumin 90.4 µM 3.18343360319345 0.000611236379455249 yes 58 0.000727697439964685 52 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3031 9088762 49.47 µM 3.1751038153557 0.000629310292165101 yes 59 0.000748914515343394 48 205253
SGTC_2066 5222451 176 µM 3.17229855250244 0.000635507355078061 yes 60 0.000756187213522862 66 2281147
SGTC_236 1509-0011 5.31 µM 3.15922838882878 0.000665130066037037 yes 61 0.000790937361718785 450 3107280
SGTC_2435 5706476 10.6 µM 3.13965099393801 0.000711890954680834 yes 62 0.000845746096037349 55 5725375
SGTC_9 0092-0002 10.449 µM 3.12318649828701 0.000753543016900835 yes 63 0.000894521726169193 65 759368
SGTC_230 MPP+ 141.667 µM 3.09114348438099 0.000841109857282811 yes 64 0.000996936296643385 54 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_376 3970-0862 59.1 µM 3.08952417443472 0.000845774253756559 yes 65 0.00100238695385533 55 3135186
SGTC_871 0574-0004 149 µM 3.06567682998167 0.000917278730344943 yes 66 0.00108588956597748 93 9551173
SGTC_2165 5727197 32.143 µM 3.03673223131935 0.00101151484660505 no 67 0.00119578901670798 88 1361712
SGTC_913 3487-1245 167 µM 3.02007227194085 0.00106970447813418 no 68 0.00126357187533926 82 4016153
SGTC_631 k072-0230 41.5 µM 2.98315872716222 0.00120972445033048 no 69 0.00142644999232407 65 5773147
SGTC_386 1509-0011 3.07 µM 2.96651804329805 0.0012781718203157 no 70 0.0015059634380011 201 3107280
SGTC_2967 9089538 49.85 µM 2.94914947567554 0.00135337511766792 no 71 0.00159324907983714 85 728216
SGTC_780 0109-0199 192 µM 2.94412928553013 0.00137585293416901 no 72 0.00161932339676771 65 610414
SGTC_1389 3405-0187 19 µM 2.93216606973265 0.00143079925657611 no 73 0.00168303348779718 61 799890
SGTC_1032 k061-1018 98.7 µM 2.92691855983638 0.00145552691333305 no 74 0.00171169255906633 73 4005393
SGTC_2575 plumbagin 510 nM 2.92245176568052 0.00147688227544383 no 75 0.00173643703662469 95 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_758 0868-0029 16 µM 2.87788251184329 0.00170616771005177 no 76 0.00200177106628723 43 762687
SGTC_272 doxorubicin 8.13 µM 2.85303590653565 0.00184762947143738 no 77 0.00216518641547376 100 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2608 thymoquinone 42.66 µM 2.82750142243723 0.00200404196514822 no 78 0.00234564035054346 74 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2429 5902844 64.44 µM 2.80927797339766 0.0021229197552997 no 79 0.00248263772315288 106 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_74 000s-0487 160.283 µM 2.78807496582501 0.00226926002624764 no 80 0.00265111363359356 77 677548
SGTC_1079 idarubicin 2.36 µM 2.78177856800801 0.00231444368537554 no 81 0.00270309561003672 68 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_781 4335-2806 94.4 µM 2.75084203697938 0.00254850483403319 no 82 0.0029721149786335 78 845254
SGTC_2004 4023728 41.89 µM 2.74243657322886 0.0026156929231461 no 83 0.00304926132458884 101 360084 YDR527W RBA50
SGTC_2043 5101342 149 µM 2.73370957033674 0.0026871406383319 no 84 0.00313126280405902 81 678451
SGTC_2037 5169046 200 µM 2.72485661490589 0.00276141552333972 no 85 0.00321647086624444 63 5718022
SGTC_351 caspofungin 25 nM 2.72133626142414 0.00279146201183156 no 86 0.0032509293199579 207 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_695 3505-6186 243 µM 2.69440722101909 0.00303123782839249 no 87 0.00352569774793698 81 1819379
SGTC_1513 0337-0559 19 µM 2.68875177291324 0.00308389183235752 no 88 0.00358598642567557 99 775073
SGTC_1530 rhein 70.4 µM 2.68337579584799 0.00313470594936081 no 89 0.00364415209113313 90 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_949 1165-0505 146 µM 2.65994946630422 0.00336504345446572 no 90 0.00390761881195133 105 6244267
SGTC_3068 9116768 49.47 µM 2.65728269502023 0.00339220614154666 no 91 0.00393866783349104 102 41904888
SGTC_606 k015-0008 38.6 µM 2.65497986946312 0.00341582018815953 no 92 0.00396565707331331 95 1970475
SGTC_1031 k035-0009 16 µM 2.6534239502616 0.00343185868140642 no 93 0.00398398617336677 117 5180959
SGTC_2701 st077767 14.721 µM 2.6412332505463 0.00355988121765591 no 94 0.0041302413576448 138 5721188
SGTC_1300 1094-0077 113 µM 2.63139389471431 0.00366632000282245 no 95 0.00425177077671666 68 5532636
SGTC_1387 3342-1166 1.8 µM 2.63085320954791 0.00367225086710522 no 96 0.0042585407228323 63 3418228
SGTC_56 0957-0365 83.25 µM 2.61340462462293 0.00386832796413475 no 97 0.00448225502509203 142 6752360
SGTC_1054 3429-0080 167 µM 2.61004813564736 0.00390710475792219 no 98 0.00452647416017589 104 1162877
SGTC_1554 st069299 38.7 µM 2.5705547544915 0.00439022320214768 no 99 0.00507678872671848 98 24207999
SGTC_2682 pyrogallin 40.03 µM 2.56986286299559 0.00439914306735999 no 100 0.00508693903486047 129 822798 An ATP competetive kinase inhibitor.
SGTC_702 1488-0190 94 µM 2.55959528580477 0.00453342900282995 no 101 0.00523970616231799 76 949357
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 2.55786628229772 0.00455639860454825 no 102 0.00526582902926972 89 7104
SGTC_1552 6-methylflavone 10.6 µM 2.55118067080866 0.00464619678102571 no 103 0.005367932796158 70 689013
SGTC_2760 etidronate 98.04 µM 2.54063975136893 0.00479098777511709 no 104 0.00553249316631747 120 3305 A chelator and antioxidant.
SGTC_1836 st055642 81 µM 2.5322093127812 0.00490967036314574 no 105 0.0056673153739831 130 8571
SGTC_2784 7567673 72.73 µM 2.5297824684401 0.00494431734891002 no 106 0.00570666316205301 138 3471247
SGTC_3343 9148379 18.9835 µM 2.52037884143151 0.0050806350829745 no 107 0.00586142940421823 82 1955036
SGTC_1274 0865-0114 173 µM 2.51970475958981 0.00509053410072613 no 108 0.00587266523400632 105 870624
SGTC_1540 guanosine 70.6 µM 2.51945115446422 0.00509426278236395 no 109 0.00587689735537963 79 6802 Guanosine is a purine nucleoside
SGTC_1281 0884-0031 11.8 µM 2.51040193126297 0.00522891223249771 no 110 0.00602969066278147 130 1548255
SGTC_1211 1056-0033 32.3 µM 2.48933453224553 0.00555472661209894 no 111 0.00639912388731954 78 6741922
SGTC_979 1426-2828 121 µM 2.45990582130697 0.00604001577666691 no 112 0.00694867394865238 131 747872
SGTC_2053 5265679 138 µM 2.44622502926705 0.00627814568959313 no 113 0.00721804335412506 151 764595
SGTC_392 N-ethylmaleimide 8.33 µM 2.43866734746958 0.00641322903320541 no 114 0.00737076567473427 115 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2713 st079149 53.4 µM 2.42614560235083 0.00664270454733618 no 115 0.00763007326875268 137 3103253
SGTC_2266 7929956 200 µM 2.42241401202799 0.00671247985729149 no 116 0.00770888704338036 138 2967153
SGTC_2671 danthron 100 µM 2.41549374447023 0.00684359489209196 no 117 0.00785694620387207 160 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1564 D-Arginine 115 µM 2.41434123818654 0.00686564925080816 no 118 0.00788184557921022 145 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1891 st059073 26.2 µM 2.40490900875364 0.00704851595366803 no 119 0.00808824648712346 129 688754
SGTC_1322 1348-1070 12 µM 2.39332068078629 0.00727905877589181 no 120 0.00834832036032518 78 6758089
SGTC_2310 7668677 200 µM 2.38804533931882 0.00738619280601575 no 121 0.00846912600316124 154 2197143
SGTC_2141 5621638 7.665 µM 2.35987638360179 0.00798210850628542 no 122 0.00914051280354426 115 2856238
SGTC_877 0771-0151 33.1 µM 2.35012222219568 0.00819809726954475 no 123 0.00938362375123663 132 6166523
SGTC_2232 chlorophetanol 41.5365 µM 2.33898297465489 0.00845102144725031 no 124 0.00966815731986466 281 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1837 st055472 66.5 µM 2.33444607234269 0.00855598178658001 no 125 0.00978618836190275 137 676091
SGTC_1369 1866-0067 208 µM 2.31095443617846 0.00911794963225331 no 126 0.0104176858804343 180 3531355
SGTC_2567 aureobasidin a 60 nM 2.30021560175866 0.00938543281129376 no 127 0.010718004176589 255 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3173 9105693 49.47 µM 2.29690300374717 0.0094693166396402 no 128 0.0108121518034962 168 17096658
SGTC_28 pentachloropyridine N-oxide 1.606 µM 2.29611755754883 0.00948930212602601 no 129 0.010834580333379 205 140250 A respiratory chain inhibitor.
SGTC_2358 9037157 4 µM 2.28984846957291 0.00965014383177897 no 130 0.0110150511445174 165 2388925
SGTC_134 0269-0018 6.916 µM 2.28933604061737 0.00966339559082654 no 131 0.0110299175981999 284 4378915
SGTC_2219 9098279 200 µM 2.28910660003063 0.00966933423179647 no 132 0.0110365797229423 101 902349
SGTC_960 1222-0186 7.7 µM 2.28566492805211 0.00975879895358588 no 133 0.0111369342725222 162 3126296
SGTC_3151 9099821 49.47 µM 2.28176468057965 0.00986105743669915 no 134 0.0112516185304921 150 17174189
SGTC_2684 capsaicin 100 µM 2.27824963604051 0.00995401690538571 no 135 0.0113558542410774 132 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_140 0062-0056 502.533 µM 2.2756947503269 0.0100220630913574 no 136 0.011432142892564 167 3758964
SGTC_3153 9100258 49.47 µM 2.2679087298667 0.0102319440462989 no 137 0.0116673850780826 167 25236848
SGTC_602 3130-1533 38.1 µM 2.25669990284745 0.010540818871047 no 138 0.0120134164660811 175 720941
SGTC_777 1315-0167 517 µM 2.25248489077758 0.0106590539606793 no 139 0.012145823237458 153 4221767
SGTC_1112 tnp00069 1.16933 µM 2.25217103094242 0.0106679040540607 no 140 0.0121557329700398 165 145826
SGTC_1831 st055328 12 µM 2.24513291658802 0.0108680495988284 no 141 0.0123798005170185 170 1103068
SGTC_604 1000-0114 314 µM 2.23875925972366 0.0110521115795064 no 142 0.0125857922034189 161 1572745
SGTC_2763 lisinopril 49.32 µM 2.23176514241866 0.0112572061063865 no 143 0.0128152446373153 106 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_752 1896-0090 130 µM 2.22501020863658 0.011458419271127 no 144 0.0130402764175582 151 772567
SGTC_1571 st070080 73.4 µM 2.21158789792037 0.0118675252818616 no 145 0.0134975761903959 157 4315245
SGTC_1085 doxorubicin 7.67 µM 2.20717874605374 0.0120046512295405 no 146 0.013650787014544 187 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_467 ro 31-8220 72.8 µM 2.206052142922 0.0120399085418083 no 147 0.0136901744992095 249 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_968 1309-0633 340 µM 2.20571656935737 0.0120504277360123 no 148 0.0137019255162046 145 3761976
SGTC_1568 digitonin 820 nM 2.20308361555263 0.0121332395977415 no 149 0.0137944278905135 192 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_3124 9127567 49.47 µM 2.19435652438453 0.012411261844178 no 150 0.0141048944061832 143 17592030
SGTC_847 0342-0274 5.54 µM 2.17470128314653 0.0130577043229685 no 151 0.014826254342624 159 18097
SGTC_705 1124-0212 310 µM 2.17059558176858 0.0131963524009072 no 152 0.0149808781845413 166 9554485
SGTC_2806 7952793 58.44 µM 2.16461392729351 0.0134006265854179 no 153 0.0152086317682948 177 2972490
SGTC_875 0709-0210 25.7 µM 2.15848320033803 0.013612819305853 no 154 0.0154451415891057 203 6251364
SGTC_1715 st032160 10.2275 µM 2.15264205093178 0.0138176804272715 no 155 0.0156734105089096 193 5289825
SGTC_3327 9140648 26.9345 µM 2.15250483800359 0.0138225245585705 no 156 0.015678807325138 144 8029710
SGTC_512 prima-1 270 µM 2.15112963603632 0.0138711553025502 no 157 0.0157329844585522 166 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1641 st009299 47.1 µM 2.14438020459302 0.014111977548146 no 158 0.0160012175308221 114 4046054
SGTC_1384 3089-0840 101 µM 2.14140440803265 0.0142192942682145 no 159 0.0161207198893056 148 1069836
SGTC_2074 5212007 75.395 µM 2.12899911865408 0.0146742762098736 no 160 0.0166271666602074 154 758611
SGTC_2335 9018011 154.17 µM 2.12449710360539 0.0148424639234859 no 161 0.0168142989955249 211 6458208
SGTC_1526 st051518 75 µM 2.08830016549425 0.0162559665231735 no 162 0.0183853832738139 184 673993
SGTC_737 1950-0117 57.9 µM 2.07841964684279 0.0166612793054099 no 163 0.018835362352329 199 5393513
SGTC_1101 ebselen 5.29 µM 2.07552774224471 0.0167815329431755 no 164 0.0189688252277113 201 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1208 2323-2347 50.3 µM 2.07021177240714 0.0170045233759744 no 165 0.0192162586584689 179 5412760
SGTC_1207 2099-0101 141 µM 2.06671413998925 0.0171526170406779 no 166 0.0193805489944421 205 5837381
SGTC_1400 3771-8998 51.5 µM 2.06546388816389 0.0172058208284583 no 167 0.0194395644898198 129 670767
SGTC_84 0443-0269 128.823 µM 2.05194684221748 0.0177900907693148 no 168 0.0200874144064911 220 6150058
SGTC_3101 9120531 49.47 µM 2.04405398413851 0.0181390217270972 no 169 0.0204741071761929 234 24824904
SGTC_637 1181-0519 7.26 µM 2.04042243812529 0.0183015159717356 no 170 0.0206541344731535 330 6252091 YGR060W ERG25
SGTC_1499 4480-0877 67.3 µM 2.03315744031547 0.0186303142902774 no 171 0.0210183096610098 135 2861909
SGTC_324 1315-0088 19.6 µM 2.02921643165026 0.0188107703544721 no 172 0.0212181253289119 157 6787421
SGTC_751 0833-0568 350 µM 2.02868650813909 0.0188351482529488 no 173 0.0212451154833012 199 6954252
SGTC_150 3970-0969 77.2 µM 2.0270672801517 0.0189098036829962 no 174 0.0213277662599894 303 6615640
SGTC_69 0096-0274 206.684 µM 2.02407647202809 0.0190483585316389 no 175 0.0214811420135175 292 6741392
SGTC_1359 1582-0056 520 nM 2.02403453666717 0.0190503073874732 no 176 0.0214832991691816 241 3661189
SGTC_2921 7974240 10.71 µM 2.01764939296812 0.0193490281793102 no 177 0.0218138944319032 243 2979074 YDR527W RBA50
SGTC_333 3486-0131 40.1 µM 2.01094779535266 0.0196668254842908 no 178 0.0221654855843887 196 6744690
SGTC_1239 0337-0584 35.4 µM 2.0045944006454 0.0199721920426664 no 179 0.0225032128699964 279 914301 YML130C ERO1
SGTC_1877 wortmannin 25 µM 1.99779008165432 0.0203036831920668 no 180 0.0228697115448321 322 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.97900215117153 0.0212432977405315 no 181 0.0239078820332775 235 94937 An inhibitor of serotonin biosynthesis.
SGTC_1620 st003704 16.5 µM 1.97682502226151 0.0213545203367627 no 182 0.0240307061316988 185 2834414
SGTC_2518 prenyletin 46.28 µM 1.9605757866562 0.022200293188423 no 183 0.0249642646144582 134 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2075 5212009 200 µM 1.9555870294004 0.0224655625835933 no 184 0.0252569110325963 178 780898
SGTC_2198 6589944 200 µM 1.95490731296469 0.0225019115213405 no 185 0.0252970056251358 176 5290268
SGTC_3056 9094900 49.47 µM 1.94998458872626 0.0227666451203769 no 186 0.0255889779657676 250 25236784
SGTC_319 1348-1596 45.5 µM 1.94489992833534 0.0230428380387868 no 187 0.025893511837953 227 5380505
SGTC_1832 st054113 55 µM 1.9398863467764 0.0233179275384173 no 188 0.0261967518591878 184 1251267
SGTC_2691 st077356 60.2 µM 1.93559051113471 0.0235558289456642 no 189 0.0264589367257552 250 2839272
SGTC_2455 5377712 9.75 µM 1.93270688623629 0.0237166653329694 no 190 0.026636158205637 219 2243908
SGTC_2469 5655019 90.81 µM 1.93184796919518 0.0237647501997616 no 191 0.0266891366893366 251 2788239
SGTC_487 nimodipine 119 µM 1.92898012003332 0.0239258955022066 no 192 0.0268666651284001 141 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2933 9026794 32.47 µM 1.92585213838878 0.0241027038061623 no 193 0.0270614195404772 271 17586027
SGTC_2917 7979103 53.79 µM 1.91571198634448 0.0246834369388051 no 194 0.0277008829453814 297 2980565
SGTC_733 4069-0007 56.1 µM 1.91311077426023 0.0248342878181045 no 195 0.0278669363669465 351 5717425 YNL287W SEC21
SGTC_2415 st077333 57.7 µM 1.91258933975457 0.0248646199734365 no 196 0.0279003227293322 334 2766255
SGTC_3175 9106517 49.47 µM 1.90933197602398 0.0250548068174181 no 197 0.0281096399276559 212 41468073
SGTC_3149 9097855 49.47 µM 1.90839460375929 0.0251097623485281 no 198 0.0281701168916072 227 25236625 YMR079W SEC14
SGTC_2177 5811945 192 µM 1.90574548048412 0.0252656195808534 no 199 0.0283416177359303 244 5343475
SGTC_1702 st027038 51 µM 1.90418304644502 0.0253579225009709 no 200 0.0284431744576844 259 5521182
SGTC_3228 9131799 49.47 µM 1.90197022392953 0.0254891312080735 no 201 0.0285875237203243 210 17015818
SGTC_3132 9126706 49.47 µM 1.89927308475621 0.0256498257028554 no 202 0.0287642899011458 238 850858
SGTC_1041 0206-0046 107 µM 1.8936281825698 0.0259888928268798 no 203 0.0291371900029551 244 50494
SGTC_898 1000-0849 28.3 µM 1.89189995693619 0.0260934472196519 no 204 0.0292521557683888 200 6751807
SGTC_699 0375-0592 111 µM 1.8907675143719 0.026162148455958 no 205 0.0293276927300513 227 762578
SGTC_2988 9073640 71.4286 µM 1.88313771608696 0.0266289739713791 no 206 0.0298408535465206 241 9102229
SGTC_1699 st031318 29.054 µM 1.88250811623775 0.0266678045779219 no 207 0.0298835294696313 236 5340658
SGTC_3142 9086498 49.47 µM 1.88195448323979 0.0267019889930531 no 208 0.0299210979787138 241 25236367
SGTC_1395 3486-0190 4.35 µM 1.87773644604771 0.0269636377630386 no 209 0.0302086141303253 250 6748079
SGTC_1164 k060-0068 93.7 µM 1.87497227720889 0.0271362598027077 no 210 0.03039826876238 286 5963676
SGTC_859 0439-0102 54.6 µM 1.86357887110392 0.0278575393030196 no 211 0.0311904335427552 273 610143
SGTC_1422 4031-0024 15.5 µM 1.86137855538067 0.0279986582666331 no 212 0.0313453683803327 250 782427
SGTC_2430 5571206 200 µM 1.8543857352202 0.0284511063816025 no 213 0.0318419970679687 310 1731771
SGTC_39 0986-0283 58.349 µM 1.85157691779173 0.0286345464698715 no 214 0.0320433000604603 317 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.84594378935291 0.0290054036875858 no 215 0.0324501837953582 266 4330530
SGTC_562 3772-2733 112 µM 1.84431171113729 0.0291135943770759 no 216 0.0325688628686476 343 2876874 YIL048W NEO1
SGTC_1205 4161-2785 76 µM 1.83785079872783 0.02954518509247 no 217 0.0330421969091864 257 3498106
SGTC_2352 9027995 87.8 µM 1.83350357819563 0.0298385590724557 no 218 0.0333638584651678 222 2997347
SGTC_1451 4152-0210 104 µM 1.82502160018131 0.0304179272876414 no 219 0.0339988849127551 297 659563
SGTC_1313 1220-0047 237 µM 1.82310350312859 0.0305502285195418 no 220 0.0341438580670568 345 3528706
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.81384899762755 0.0311952748596933 no 221 0.0348504883246909 303 688667
SGTC_2583 asiatic acid 100 µM 1.81116379377307 0.0313845305229261 no 222 0.0350577504635973 273 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1150 3909-7983 10.9 µM 1.80708972744688 0.031673486602505 no 223 0.0353741450411375 319 23965914
SGTC_727 3032-0951 202 µM 1.8061595429544 0.0317397679555521 no 224 0.0354467111655929 274 3652836
SGTC_2871 9038510 12.99 µM 1.79557370096285 0.0325021786361546 no 225 0.0362811708003034 288 4945164
SGTC_712 r015-0009 80.6 µM 1.79374531773557 0.0326353797670251 no 226 0.0364269142339226 249 6813872 YLR060W FRS1
SGTC_2143 5623677 140.463 µM 1.78987927557275 0.0329185107337667 no 227 0.0367366605898909 221 5375313
SGTC_46 0329-0187a 2.197 µM 1.78828956112549 0.0330355199634585 no 228 0.036864651578086 401 46494817
SGTC_1017 4239-0030 168 µM 1.78424542383768 0.0333347299106711 no 229 0.0371918970966405 324 1149593
SGTC_496 calpeptin 138 µM 1.78206220497357 0.0334971831297962 no 230 0.0373695441519789 265 73364 A calpain inhibitor.
SGTC_1685 st024049 53.0905 µM 1.78201600234721 0.0335006280949806 no 231 0.0373733111048872 258 1941139
SGTC_2208 7283366 200 µM 1.7793497331675 0.0336999253559233 no 232 0.0375912210399106 273 898663
SGTC_1698 5-fluorocytosine 1.055 µM 1.77763280979328 0.0338287769390447 no 233 0.0377320907418333 264 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_68 0986-0284 82.829 µM 1.77748078882221 0.0338402053072575 no 234 0.037744584458614 334 423278 YIL048W NEO1
SGTC_1996 st072960 66.8 µM 1.77594236136375 0.0339560373331138 no 235 0.0378712089203577 291 1719405
SGTC_3076 9116187 49.47 µM 1.76977281754594 0.0344238381149955 no 236 0.0383824969181747 268 27241210
SGTC_1520 flindersine 88 µM 1.75146631074058 0.0358431666896526 no 237 0.039932809725332 316 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_501 nsc-95397 161 µM 1.74462737104712 0.0363855521030948 no 238 0.0405248765907823 256 262093
SGTC_548 1436-0017 110 µM 1.74308966929316 0.0365084252052673 no 239 0.0406589764327551 371 9677137
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.74225618376448 0.0365751682783611 no 240 0.0407318133842023 338 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2296 7971656 126.45 µM 1.73871564169853 0.0368597980241828 no 241 0.0410423966526842 345 666570
SGTC_2991 9074669 71.4286 µM 1.73324287440316 0.0373033236175874 no 242 0.0415262547416517 371 17333109
SGTC_612 0302-0167 22.4 µM 1.71555786987517 0.0387664476435296 no 243 0.0431214975280282 387 235821
SGTC_2159 5658611 73.75 µM 1.7126488540282 0.0390115363819043 no 244 0.0433885798915665 271 793844
SGTC_762 1165-0429 115 µM 1.71005294992843 0.039231308845565 no 245 0.0436280410411703 319 5967793
SGTC_2048 5246248 200 µM 1.70882335158665 0.0393357592840402 no 246 0.0437418379133297 247 677046
SGTC_3069 9117009 49.47 µM 1.70237746244389 0.0398870250640258 no 247 0.0443423160678334 208 41904981
SGTC_1355 1499-0035 1.68 µM 1.69515690300207 0.0405119818615397 no 248 0.0450228300078049 326 1548538
SGTC_986 1493-0483 84 µM 1.69325492217779 0.0406779190134575 no 249 0.0452034772285572 299 40079
SGTC_2808 7946468 45.46 µM 1.69231732290094 0.0407599220360602 no 250 0.0452927433247893 376 2970879
SGTC_3048 9093155 49.47 µM 1.69064076893245 0.0409068888483823 no 251 0.0454527165981734 259 25236002
SGTC_3177 9107506 49.47 µM 1.68175754911195 0.0416927804848639 no 252 0.0463079317596358 253 8897194
SGTC_2962 9082311 13.18 µM 1.66285077154603 0.0434061704350957 no 253 0.0481711553155246 317 16459453
SGTC_2345 9052315 157.45 µM 1.66151448153152 0.0435293890367728 no 254 0.048305081456768 348 6469265
SGTC_1348 1493-0373 93.8 µM 1.65998874269615 0.0436704216500706 no 255 0.0484583586086154 308 3010129
SGTC_2431 5490079 200 µM 1.64948040963564 0.0446518081699098 no 256 0.0495246266845129 359 5722345
SGTC_2112 5488546 200 µM 1.64857968622534 0.0447367478795659 no 257 0.0496168865947412 359 600757
SGTC_2667 digitoxin 100 µM 1.64846745873901 0.0447473402275079 no 258 0.0496283915107432 222 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1012 4112-3522 18 µM 1.64473258540329 0.045101001617618 no 259 0.0500124849403611 341 3112398
SGTC_385 1494-0393 12.4 µM 1.63509272067358 0.0460242183292471 no 260 0.0510148059590011 358 3090647
SGTC_3027 9089541 49.47 µM 1.63223142279245 0.0463011498736231 no 261 0.0513153717772895 375 9943819
SGTC_3203 9113543 49.47 µM 1.63023077031459 0.0464955772151765 no 262 0.0515263664623524 371 17018012
SGTC_2420 aureobasidin a 50 nM 1.62945353526461 0.0465712869599868 no 263 0.0516085217822917 419 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1411 3909-8223 150 µM 1.62321476225955 0.0471825902303708 no 264 0.0522717515985853 363 X1411
SGTC_1855 st056195 39.6 µM 1.62088355770598 0.0474126563978031 no 265 0.0525213068866717 356 4028379
SGTC_2451 5856223 45.7 µM 1.62001038413853 0.047499060791357 no 266 0.0526150231440705 349 2179896
SGTC_2743 auranofin 4.32 µM 1.61767312782483 0.0477309635099284 no 267 0.0528665300693665 334 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1459 k035-0031 35.7 µM 1.61609922100542 0.0478876368461577 no 268 0.0530364313235031 298 3877128 YMR208W ERG12
SGTC_3352 9151559 45.5865 µM 1.61516919349659 0.0479804090558801 no 269 0.0531370299640486 347 17159339
SGTC_1418 3966-3099 2.4 µM 1.61292497397608 0.0482048671353939 no 270 0.0533804043393274 385 740335
SGTC_1221 2958-7315 257 µM 1.60732948896635 0.048768165222511 no 271 0.053991054359603 369 4562705
SGTC_2356 9061756 188.97 µM 1.6048622094843 0.049018212098404 no 272 0.0542620658790954 314 20104043
SGTC_2740 felodipine 17.08 µM 1.60310105753102 0.0491973220130493 no 273 0.0544561722907893 276 3333 L-type calcium channel blocker
SGTC_3096 9117468 49.47 µM 1.59982492280887 0.0495318964714813 no 274 0.054818714127845 260 41316311
SGTC_649 1123-0311 367 µM 1.59771166696771 0.0497486739859866 no 275 0.0550535805217386 431 693629 YIL048W NEO1
SGTC_1467 k284-1082 293 µM 1.57984230593077 0.0516121084506122 no 276 0.0570714922152419 377 3334705
SGTC_1579 chlormadinone acetate 49.4 µM 1.57884700506473 0.0517175093271247 no 277 0.0571855769919592 385 45114258 A steroidal progestin.
SGTC_931 2812-0076 566 µM 1.57784440642845 0.0518238559431314 no 278 0.0573006796594028 393 3450959
SGTC_2164 5685496 200 µM 1.57423871251074 0.052207752515428 no 279 0.057716136315262 366 759046
SGTC_151 3013-0144 2.285 µM 1.55672104368284 0.0541050925825975 no 280 0.0597683650908086 415 906558 YHR107C CDC12
SGTC_1115 galangin 695.678 nM 1.5551576551102 0.054277042253956 no 281 0.0599542632306539 422 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_620 0109-0052 432 µM 1.55421456269388 0.0543809774009791 no 282 0.060066622483323 390 493037
SGTC_2749 bexarotene 57.39 µM 1.5500025114883 0.0548470969774026 no 283 0.0605704566014449 412 82146 An retinoic acid receptor inhibitor.
SGTC_2588 indole-3-carbinol 100 µM 1.54855450122962 0.0550080660440272 no 284 0.0607444252846847 451 3712 Induces cell cycle arrest.
SGTC_2380 9035439 200 µM 1.54185069470467 0.0557581692888715 no 285 0.0615549398509318 454 6462575
SGTC_1985 st071382 65.5 µM 1.54129421184378 0.0558207964011476 no 286 0.0616225984895623 377 6123237
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.54012930889139 0.0559520753763691 no 287 0.0617644184317267 361 2374 Ca(2+)-ATPase inhibitor.
SGTC_2336 9001819 198.65 µM 1.53924395983781 0.056052012758548 no 288 0.0618723746786134 444 2989602
SGTC_1332 1480-0653 17.5 µM 1.53103053410855 0.0569858608240531 no 289 0.0628809232063859 416 5749438
SGTC_2935 9038016 29.96 µM 1.53076485875285 0.0570162708101273 no 290 0.0629137587865439 428 6463195
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.5287514719857 0.0572471444880885 no 291 0.0631630334146426 396 4213774
SGTC_253 dyclonine 31.25 µM 1.5254319199274 0.0576294010003005 no 292 0.0635757011214283 459 3180 An oral anasthetic.
SGTC_2045 5106652 78.05 µM 1.52454282112549 0.0577321235066816 no 293 0.0636865842374756 386 673349
SGTC_1346 1488-2224 62.4 µM 1.52085381510701 0.0581598734887173 no 294 0.0641482630598003 404 3722427
SGTC_3190 9110366 49.47 µM 1.51770646392916 0.0585267822155962 no 295 0.064544206913546 338 17123768
SGTC_2702 st077768 96.8 µM 1.51391853327055 0.0589707749217862 no 296 0.0650232514761972 386 6484119
SGTC_3001 9076041 71.4286 µM 1.51330310696979 0.0590431594503252 no 297 0.0651013419308189 406 16004211
SGTC_908 3448-7491 47.7 µM 1.51285883955913 0.0590954561059259 no 298 0.0651577595281335 545 1203031
SGTC_249 wiskostatin 11.211 µM 1.5030041781882 0.0602648580330583 no 299 0.066418983281529 408 2775510 A n-wasp and actin depolymerizer.
SGTC_2295 7971645 200 µM 1.50284520903425 0.0602838694663861 no 300 0.0664394823682275 429 2978226 YKL099C UTP11
SGTC_3269 9137823 49.47 µM 1.49959950078087 0.0606730573360096 no 301 0.0668590885474498 376 17682936
SGTC_1808 st050063 61.5 µM 1.49572798744302 0.0611398515723602 no 302 0.0673622769465261 411 4011993
SGTC_1711 st032263 62.8 µM 1.49446345847991 0.0612929243356337 no 303 0.0675272629939629 408 3958979
SGTC_462 ag-879 158 µM 1.4942769593127 0.0613155256010207 no 304 0.0675516223761727 456 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2888 9058547 12.99 µM 1.49159236993079 0.0616415847232109 no 305 0.0679030198350335 338 16476514
SGTC_270 tamoxifen 5.46 µM 1.48424226817193 0.0625412268809506 no 306 0.0688723300131791 465 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_879 0831-1030 162 µM 1.48082808249204 0.062962584878109 no 307 0.0693261955887842 504 1549252
SGTC_2666 tannic acid 100 µM 1.47956561764181 0.0631189494573176 no 308 0.0694946039089543 472 16134267 A thiamine antagonist.
SGTC_990 3985-0011 41.3 µM 1.47409449046873 0.0638000820595621 no 309 0.070228075872672 391 5399565 YGL099W LSG1
SGTC_2050 5263056 171 µM 1.47223315843512 0.0640331091124907 no 310 0.0704789630803637 513 763468 YGL055W OLE1
SGTC_213 1246-0773 967 nM 1.47190984126193 0.0640736537609073 no 311 0.0705226128508098 457 6251622
SGTC_1519 esterone 74 µM 1.47169443847565 0.0641006767962505 no 312 0.0705517050596127 458 698 A steroid.
SGTC_2983 9022671 12.99 µM 1.46910092705301 0.0644267378877501 no 313 0.0709027081815579 406 6405161
SGTC_2629 bisabolol 100 µM 1.46882933763386 0.0644609570221619 no 314 0.0709395422661329 459 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_61 0978-8327 98.565 µM 1.46601292658782 0.0648166460568315 no 315 0.0713223826435538 455 6150059 YHR072W ERG7
SGTC_1504 k297-0033 30 µM 1.4641389267408 0.0650541595452884 no 316 0.0715779965889002 355 4388117
SGTC_1142 3253-1408 9.78 µM 1.46023101299316 0.0655516267665479 no 317 0.0721132973129871 423 256655
SGTC_622 1348-1566 26.3 µM 1.45736820617862 0.0659179228515227 no 318 0.0725073842462646 483 7340407
SGTC_634 1611-4317 11.2 µM 1.45588516658212 0.0661083003967374 no 319 0.0727121834407352 477 2843522
SGTC_2483 5729050 27.16 µM 1.45349325456279 0.0664162468670401 no 320 0.0730434256031423 552 2865180
SGTC_1529 apigenin 74 µM 1.45201871232061 0.0666066393227205 no 321 0.0732482011467407 490 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_717 1532-0246 73.2 µM 1.45073615308285 0.066772586267673 no 322 0.0734266721393845 469 9561992
SGTC_204 PMA1.184 62.41 µM 1.45062114153584 0.0667874829236101 no 323 0.0734426924884485 511 2252213 YGL008C PMA1
SGTC_163 TUB2.036 7.546 µM 1.45025707842698 0.066834654471537 no 324 0.0734934216992993 629 15992207 YJR013W GPI14
SGTC_2515 chrysin 20.77 µM 1.44696295327003 0.067262645844703 no 325 0.0739536498654562 441 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2827 7993847 71.43 µM 1.44145421370844 0.0679831029491875 no 326 0.0747282018243254 396 2985692
SGTC_2852 9023854 51.95 µM 1.43912173539165 0.0682899443102579 no 327 0.075058017395199 477 19798528
SGTC_1266 0828-0227 32.9 µM 1.43314084503779 0.0690816238970411 no 328 0.0759087954024212 431 3913820
SGTC_3271 9137798 49.47 µM 1.43093023598337 0.069376021862244 no 329 0.0762251052086842 385 6498326
SGTC_2919 7978188 46.38 µM 1.42889087059501 0.0696484705263126 no 330 0.0765178009098975 478 2980291
SGTC_3231 9132313 49.47 µM 1.4288044812304 0.0696600298583009 no 331 0.0765302186139442 457 4905967
SGTC_874 0599-0792 117 µM 1.42670393474737 0.0699415483315289 no 332 0.0768326255069492 532 765305
SGTC_1859 st055998 20 µM 1.41979833428138 0.0708732194728373 no 333 0.077833200024807 483 676301
SGTC_1455 4262-0120 131 µM 1.41936431123302 0.0709320927442845 no 334 0.0778964157791907 467 1529587
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.41616402890039 0.0713673569575321 no 335 0.078363742481944 525 676296 Flavone; oxidizing agent.
SGTC_679 0422-0091 41.4 µM 1.41460115136957 0.0715806645842246 no 336 0.078592735520284 511 627384 YHR062C RPP1
SGTC_2097 5376186 200 µM 1.41282224889851 0.0718240510253481 no 337 0.0788539973482426 486 742755
SGTC_2626 ethyl orsellinate 100 µM 1.41063564256817 0.0721240877792086 no 338 0.0791760381839794 463 75653 A natural product.
SGTC_2586 curcumin 80 µM 1.41063273748141 0.0721244870408584 no 339 0.079176466703199 560 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3331 9141060 1.957 µM 1.41021638478277 0.0721817261478402 no 340 0.0792378996010294 456 4906567 YPR165W RHO1
SGTC_206 4546-0025 72.014 µM 1.40992765837307 0.0722214399577584 no 341 0.0792805224076936 553 6620745 YIL048W NEO1
SGTC_978 1416-0512 87.4 µM 1.40578149377983 0.0727935861112762 no 342 0.0798945095014719 535 6814003
SGTC_3354 9151612 71.43 µM 1.40269209590008 0.0732221562424495 no 343 0.080354337661846 509 27261949
SGTC_497 capsazepine 133 µM 1.39378451533178 0.0744686494481173 no 344 0.0816913427557771 460 2733484 A calcium channel blocker.
SGTC_3040 9091894 49.47 µM 1.39364486902447 0.0744883191977003 no 345 0.0817124360250027 420 25236966
SGTC_3199 9111318 49.47 µM 1.39186370194722 0.0747395518474028 no 346 0.0819818376863944 470 8548020
SGTC_3162 9099653 49.47 µM 1.39137784872203 0.0748081932929487 no 347 0.0820554390724127 420 25237511
SGTC_2354 9060492 162 µM 1.39104643965881 0.0748550424214883 no 348 0.082105672430458 541 6471895
SGTC_1853 st056710 91.2 µM 1.39033593135191 0.0749555577562457 no 349 0.0822134458589144 497 269167
SGTC_2601 securinine 100 µM 1.38594438542448 0.075579114105712 no 350 0.0828819430893256 479 442872 A GABA receptor antagonist.
SGTC_2710 st078562 53.7235 µM 1.38534592067185 0.0756643953408225 no 351 0.0829733593039712 467 17250908
SGTC_1880 MG-132 525 µM 1.38465175452045 0.0757634058349321 no 352 0.0830794890047351 447 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2829 7992743 58.44 µM 1.38445971127327 0.0757908148188781 no 353 0.0831088681410085 494 16462845
SGTC_2444 5485484 36.41 µM 1.38242795764542 0.0760812555313348 no 354 0.0834201683527557 514 6790631
SGTC_398 bronopol 33.3 µM 1.37965985805876 0.0764783200106842 no 355 0.0838456989748232 491 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_645 0845-0943 5.41 µM 1.37698156147647 0.0768640015448343 no 356 0.0842589742984582 491 1885106
SGTC_563 tetrahydrosecaminediol 614 µM 1.37100322524444 0.0777302289298023 no 357 0.0851869753135481 520 334274 A psychoactive constituent of the cannabis plant.
SGTC_1618 st003135 44.5 µM 1.36986202018572 0.0778964221728187 no 358 0.0853649887049186 484 1270615
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.36855047190893 0.0780877553029183 no 359 0.0855699174361934 576 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_809 3998-0021 90 µM 1.3634775264331 0.078831171256356 no 360 0.08636603125336 463 715485
SGTC_594 1487-1584 10.8 µM 1.36331284809863 0.0788553936290206 no 361 0.0863919672628928 512 5013332
SGTC_1086 cerivastatin 2.18 µM 1.35964892314494 0.0793957761446843 no 362 0.0869705242712029 473 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2351 9026858 72.31 µM 1.35812423630051 0.079621472226505 no 363 0.0872121329772958 463 1409300
SGTC_328 k915-0120 63.5 µM 1.356219081301 0.0799041699935055 no 364 0.0875147363016365 482 6624543
SGTC_1075 aripiprazole 15.2 µM 1.35569209259506 0.0799825014433221 no 365 0.0875985781961469 560 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2084 5306078 60.6385 µM 1.34811179608166 0.0811156676828368 no 366 0.0888112139888267 512 679340
SGTC_1396 3511-0007 98.6 µM 1.34206090582905 0.0820288675155144 no 367 0.089788124199756 453 X1396
SGTC_105 0111-0055 734.78 µM 1.33917711132125 0.0824668055703843 no 368 0.0902565109403014 421 5179370
SGTC_542 3381-0244 89.3 µM 1.33873382330294 0.082534279856294 no 369 0.0903286705390063 593 1112843
SGTC_592 k241-0073 46.5 µM 1.3382363910146 0.0826100450878667 no 370 0.0904096948890567 540 4230158
SGTC_930 2810-3379 265 µM 1.33645506468676 0.0828817930457013 no 371 0.0907002892270105 588 1015764
SGTC_1330 1469-0054 61.8 µM 1.33443077351081 0.0831914219352474 no 372 0.0910313601387071 524 7102664
SGTC_1303 1160-0052 261 µM 1.33382537593965 0.0832841902890975 no 373 0.0911305462506034 516 3562476
SGTC_3179 9107801 49.47 µM 1.33048067932545 0.0837981185048519 no 374 0.0916799739849307 512 4818259
SGTC_1796 st049173 110.4 µM 1.32886323491412 0.0840474992328724 no 375 0.0919465476047659 448 94134
SGTC_329 k048-0121 21.3 µM 1.3269342494913 0.0843456419960383 no 376 0.0922652167831752 496 6832902
SGTC_1377 2944-0135 198 µM 1.31988272901317 0.085442275329537 no 377 0.0934370873803553 554 1894137
SGTC_2745 rifampicin 24.3 µM 1.31887593119453 0.0855997170528702 no 378 0.093605296957739 377 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1821 st053465 65.6 µM 1.31849528480911 0.0856592985921455 no 379 0.0936689512289094 498 675086
SGTC_2647 atorvastatin 60.16 µM 1.31311780250718 0.086504341898396 no 380 0.0945716279535563 519 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2381 9035592 200 µM 1.31185133409625 0.0867042645213231 no 381 0.0947851502309913 456 4749657
SGTC_183 3914-0051 30.55 µM 1.30971491117584 0.0870422989845353 no 382 0.0951461486515023 533 1596232
SGTC_1728 st035614 33.7865 µM 1.30822534149821 0.0872785671686651 no 383 0.0953984445722347 595 15945546
SGTC_1129 3453-1384 223 µM 1.30097705035653 0.0884350923945072 no 384 0.096633155158809 604 1084452
SGTC_2625 euphol 100 µM 1.29792855624154 0.0889249018018034 no 385 0.0971559431202037 595 6708538 A triterpene alcohol.
SGTC_307 1501-1223 22.3 µM 1.29765583658484 0.0889688185982151 no 386 0.0972028129202306 551 2830329
SGTC_466 geldanamycin 89.2 µM 1.2945968669323 0.0894625195511524 no 387 0.0977296668807769 415 5288382 HSP90 inhibitor.
SGTC_2196 6573537 42.6665 µM 1.29207093051773 0.0898717254921038 no 388 0.098166290914058 517 2903087
SGTC_2606 farnesol 9.78 µM 1.29193739290712 0.0898933974618951 no 389 0.0981894134391794 563 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1132 3456-3614 2.5 µM 1.29178119408958 0.0899187520729557 no 390 0.098216464897547 658 3125502
SGTC_1023 4482-3888 16 µM 1.29167681461617 0.0899356981912453 no 391 0.0982345450104214 527 3303168
SGTC_848 0368-0089 85.6 µM 1.29120172227538 0.090012859923854 no 392 0.0983168690340182 570 762535
SGTC_1962 st076595 64.5 µM 1.29009982040088 0.0901920137506707 no 393 0.0985080011195546 552 279619
SGTC_3211 9128781 49.47 µM 1.2900288219115 0.0902035661880992 no 394 0.0985203255941651 554 17194361
SGTC_1852 st056254 31.4 µM 1.28464340893511 0.0910830544283274 no 395 0.0994584610997097 542 442583
SGTC_2035 5154463 94.595 µM 1.28171958131828 0.0915631985863156 no 396 0.0999705166864208 588 2769623
SGTC_33 0986-0033 35.816 µM 1.28101883654812 0.0916785513977822 no 397 0.100093524967866 513 2848082
SGTC_2127 5253358 187.912 µM 1.27373505778608 0.0928839497214784 no 398 0.101378663756028 506 20612
SGTC_2277 7947813 106.88 µM 1.27136167389644 0.0932792430933387 no 399 0.101800005377809 545 1246798
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.27103540937851 0.0933336803446061 no 400 0.101858025916338 493 17037758
SGTC_1316 1272-0050 65.9 µM 1.27071189984888 0.0933876810963392 no 401 0.101915580289309 569 7340392
SGTC_2370 9071495 200 µM 1.26962974765455 0.093568483474134 no 402 0.102108273943853 540 21791103
SGTC_2290 7904846 200 µM 1.26893345574818 0.093684954195319 no 403 0.102232399371175 565 2962154
SGTC_3292 9120825 59.784 µM 1.26866040772161 0.0937306569192183 no 404 0.10228110459759 575 24824900
SGTC_2228 7354201 200 µM 1.26675524620441 0.0940500006421503 no 405 0.102621409525078 542 753451
SGTC_742 0kpi-0133 140 µM 1.26656810321671 0.0940814128536278 no 406 0.102654881835194 596 2728852
SGTC_3137 9097352 49.47 µM 1.26226360796733 0.0948060664857896 no 407 0.103426973564698 625 44120435
SGTC_1388 3346-4487 254 µM 1.25475038600186 0.0960807436957079 no 408 0.104784694221953 627 3345614
SGTC_2744 captopril 92.04 µM 1.2525877768232 0.0964499723700021 no 409 0.105177882753205 491 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2856 9022925 19.48 µM 1.2500407672894 0.0968861666126486 no 410 0.105642327748456 597 4944862
SGTC_440 fluspirilene 35.1 µM 1.24840520665804 0.0971670311046718 no 411 0.105941351621164 588 3396 An atypical antipsychotic.
SGTC_520 3584-0023 682 µM 1.2442359567048 0.0978856920492045 no 412 0.106706366897484 561 1340790
SGTC_2843 9000894 45.46 µM 1.24389587006811 0.0979444847794457 no 413 0.106768944778042 432 2242070
SGTC_937 3122-0005 46.7 µM 1.24314784400541 0.0980738913941386 no 414 0.106906679013124 616 759535
SGTC_20 0481-0013 4.944 µM 1.24198644559986 0.0982750585509782 no 415 0.107120781545335 576 182045
SGTC_363 0455-0021 3.06 µM 1.24004020865239 0.0986128458051441 no 416 0.107480261181118 611 4597466
SGTC_1862 st057513 3.81 µM 1.23865374938411 0.0988539963585034 no 417 0.107736876854108 563 5393163
SGTC_1668 st014914 51.6 µM 1.2332108585859 0.0998048649590307 no 418 0.108748552594008 566 2839556
SGTC_2891 9063876 19.48 µM 1.22475091387208 0.101296045759648 no 419 0.110334542276878 526 6472478
SGTC_2847 9005661 71.43 µM 1.22450827500435 0.101339052347319 no 420 0.110380273296918 459 2991449
SGTC_1570 verbenone 133 µM 1.21979319764598 0.102177419889517 no 421 0.111271640364056 641 29025 A natural terpanoid with antifungal properties.
SGTC_568 1193-0097 7.48 µM 1.21895348568738 0.102327253214292 no 422 0.111430923720878 622 3646150
SGTC_670 4204-0025 119 µM 1.21686782680014 0.10270009727003 no 423 0.111827254224582 635 719039
SGTC_672 1441-0018 53.7 µM 1.21562064870897 0.10292352101038 no 424 0.112064732281216 572 251141
SGTC_1177 0983-0204 23.6 µM 1.21405076112513 0.103205257761017 no 425 0.112364170439732 666 766818
SGTC_1058 3448-5425 97.3 µM 1.20890781356673 0.104132148239144 no 426 0.11334913198435 604 7279705
SGTC_2844 9010103 25.97 µM 1.20728990451276 0.104424980903773 no 427 0.11366025860741 613 2480525
SGTC_2996 9066192 71.4286 µM 1.20641747862143 0.104583132612058 no 428 0.11382827999477 604 6472854
SGTC_118 0083-0097 135.343 µM 1.20582897106072 0.104689914096834 no 429 0.113941721193596 830 5207356
SGTC_1609 st001574 46.4 µM 1.20263667020689 0.105270515695242 no 430 0.114558475366525 625 3960012
SGTC_3084 9116877 49.47 µM 1.2017664009786 0.105429199792071 no 431 0.114727023241906 542 27241325
SGTC_1907 st060210 83.7 µM 1.19878498470681 0.105974140057039 no 432 0.115305781275461 688 688793
SGTC_1636 st007707 68.9 µM 1.19720974014854 0.106262882130658 no 433 0.115612407190224 681 403051
SGTC_1124 fisetin 1.16336 µM 1.19438560613048 0.106781967165164 no 434 0.116163582335376 561 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1215 3852-0577 11.2 µM 1.19388258846493 0.106874615101078 no 435 0.11626194965586 693 2884876
SGTC_1000 4048-0884 8.67 µM 1.19138496060811 0.10733549778333 no 436 0.116751247121945 627 13040088
SGTC_372 0155-0182 15.9 µM 1.18642057416008 0.108255817470927 no 437 0.117728125334401 687 771486
SGTC_1169 aniline yellow 25.8 µM 1.18632068460008 0.108274393542762 no 438 0.117747840516574 592 6051 A DNA damaging agent.
SGTC_420 mitomycin C 81.9 mM 1.18520420374654 0.108482177266539 no 439 0.11796835913384 641 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_274 sirtinol 40.1 µM 1.18323825996654 0.108848748103963 no 440 0.118357366886357 639 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2544 sphondin 68.51 µM 1.17978589943007 0.109494630493799 no 441 0.119042689540789 605 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1026 k007-1105 30.6 µM 1.17888533382267 0.109663563870536 no 442 0.119221919245604 708 7066794
SGTC_632 0781-2353 4.65 µM 1.17694402840821 0.110028361586386 no 443 0.119608923601867 670 6811515 YHR007C ERG11
SGTC_5 0352-0601 109.883 µM 1.17295788318882 0.110780140053784 no 444 0.120406347796922 586 762456
SGTC_1701 st028638 40.4 µM 1.17251097655981 0.110864654586913 no 445 0.120495983896648 643 3490878
SGTC_3266 9136860 49.47 µM 1.16769018267448 0.111779252812124 no 446 0.121465879112738 647 4871271 YPR165W RHO1
SGTC_2968 9090663 33.37 µM 1.16763501455085 0.111789750416727 no 447 0.121477010054882 650 25236811
SGTC_2428 5615643 7.78 µM 1.16713140983258 0.111885610875529 no 448 0.121578652514734 614 2253075
SGTC_1237 0330-0133 46.1 µM 1.15931984612303 0.113380064133269 no 449 0.123162917544945 610 X1237 YHR072W ERG7
SGTC_102 gallobenzophenone 83.616 µM 1.15578423671015 0.11406113183249 no 450 0.123884711153322 665 70837
SGTC_1291 0993-0025 5.79 µM 1.1526037579631 0.114676275972041 no 451 0.124536530031337 679 4353356
SGTC_2488 5268135 45.7 µM 1.14189190262504 0.116765435755982 no 452 0.126749477426573 760 1270356 YLR208W SEC13
SGTC_2331 7980721 200 µM 1.14177477629185 0.116788427355934 no 453 0.126773824773859 678 2981221
SGTC_1813 st051246 8.6015 µM 1.14049948546792 0.117038971412297 no 454 0.127039133470317 631 5291959
SGTC_3246 9135460 32.98 µM 1.13931050592566 0.117272901577043 no 455 0.127286834000155 585 41446951
SGTC_3248 9135562 49.47 µM 1.13777369838643 0.11757575685039 no 456 0.127607495148839 720 17650701
SGTC_811 0416-0114 265 µM 1.13710434321633 0.117707838143491 no 457 0.127747334255769 647 6612453
SGTC_3282 9108498 15.4605 µM 1.13268595089318 0.118582337303224 no 458 0.128673079779746 652 16459645
SGTC_312 4092-0653 6.84 µM 1.1298610418451 0.119143850649903 no 459 0.129267391014113 776 1148278
SGTC_1307 1187-1599 12.2 µM 1.12966504866908 0.119182878155881 no 460 0.129308695001426 683 1538471
SGTC_1416 3966-0321 25.3 µM 1.12717144315359 0.119680209900964 no 461 0.129835000904813 700 582530 YLR208W SEC13
SGTC_1811 st050069 61.5 µM 1.12535104287781 0.120044198727314 no 462 0.130220154035688 650 3877702
SGTC_1503 4585-0012 61.3 µM 1.12112873442539 0.120891450438563 no 463 0.13111653456575 669 2922052
SGTC_1794 st048918 76.9 µM 1.11930459954061 0.121258781429184 no 464 0.131505107128677 602 672303
SGTC_896 0964-0007 44.5 µM 1.11626216972935 0.121873188778569 no 465 0.132154964864312 702 6756758
SGTC_759 3486-0358 89.3 µM 1.11534534718561 0.122058765738148 no 466 0.132351229984049 756 875103
SGTC_3015 9080845 49.47 µM 1.11339576483716 0.122454046296736 no 467 0.132769246559269 737 5296973
SGTC_1421 4029-0249 71.4 µM 1.10847183614871 0.123456376519074 no 468 0.133829047898346 776 2894095
SGTC_1623 st003709 20.3 µM 1.10792916588427 0.123567194748853 no 469 0.13394620422662 757 16192618
SGTC_725 1497-0963 19 µM 1.10634673988421 0.123890738295133 no 470 0.134288234297074 726 3549977
SGTC_89 0302-0250 142.109 µM 1.10590842869983 0.123980460372241 no 471 0.134383078111213 746 4203518 YLR208W SEC13
SGTC_1449 4112-4002 201 µM 1.10501318367504 0.124163857836684 no 472 0.134576938281743 666 2059539
SGTC_450 aminopyrene 156 nM 1.10119178802537 0.12494883231118 no 473 0.13540659750308 720 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.10089622296507 0.12500969012014 no 474 0.135470913057082 699 6312947
SGTC_2205 7238770 200 µM 1.09779736493247 0.125649001767516 no 475 0.136146491184653 682 279867
SGTC_1781 st038725 66.3 µM 1.09189954815892 0.126872048250722 no 476 0.137438628172413 777 4270275 YIL048W NEO1
SGTC_2204 7233102 200 µM 1.09046551174706 0.127170676692178 no 477 0.137754068724236 649 2172480
SGTC_251 melphalan 456.522 µM 1.09043022490785 0.127178031099233 no 478 0.137761836883689 801 460612 A DNA alkylator.
SGTC_2670 beta-carotene 100 µM 1.08931924644832 0.127409730173522 no 479 0.13800656415393 636 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1278 0874-0585 172 µM 1.08836560702848 0.127608849572025 no 480 0.138216869013885 722 766306
SGTC_1688 st021091 57.6 µM 1.08801675547633 0.12768174360643 no 481 0.138293855347759 713 3656366
SGTC_16 erodoxin 22.806 µM 1.08798668687369 0.127688027925131 no 482 0.13830049240793 766 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_654 1124-0271 80.9 µM 1.08755733784044 0.127777785052309 no 483 0.138395286556009 730 5403748
SGTC_2949 9072542 2.23 µM 1.08667639701086 0.127962086511711 no 484 0.138589924355298 713 16457352
SGTC_162 k030-0015 37.8 µM 1.08183451292198 0.128978353017907 no 485 0.139663033966148 753 1809920 YMR134W ERG29
SGTC_1258 0671-0043 57.1 µM 1.08076876249618 0.129202793674663 no 486 0.139899993483604 706 4298767
SGTC_209 4077-0173 175.592 µM 1.08070871492973 0.129215447384379 no 487 0.139913352618041 604 15993494
SGTC_976 1348-1067 47.6 µM 1.07748775918467 0.129895452448218 no 488 0.140631208225501 780 5310671 YGL099W LSG1
SGTC_2285 7945142 200 µM 1.07744788343031 0.129903886475939 no 489 0.140640110986852 685 2970608
SGTC_511 blebbistatin 171 µM 1.07686278715525 0.130027682417837 no 490 0.140770785038516 710 3476986 A myosin inhibitor.
SGTC_1199 1638-0010 4.46 µM 1.07393935174693 0.130647452403229 no 491 0.141424932306066 743 3111136
SGTC_2675 theaflavin digallate 100 µM 1.06875913507468 0.131750670753901 no 492 0.14258910874234 746 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_3236 9132701 49.47 µM 1.06875761451289 0.131750995525133 no 493 0.142589451414564 736 24282524
SGTC_1466 k213-0079 57.5 µM 1.06809402071945 0.131892782822697 no 494 0.142739051376474 747 3657981
SGTC_52 0329-0193 875 nM 1.06593898675498 0.132353965653344 no 495 0.143225611825685 713 3739292
SGTC_442 cape 100 µM 1.06581061110799 0.132381473405792 no 496 0.143254631604669 710 5281787
SGTC_2229 7354935 190 µM 1.06537910113301 0.13247396428873 no 497 0.143352205100398 682 318112
SGTC_659 k018-0002 107 µM 1.06412266898632 0.132743524508454 no 498 0.143636566398392 751 6797879 YHR007C ERG11
SGTC_840 0245-0196 390 µM 1.06193196305492 0.133214430796987 no 499 0.144133286687687 794 3827528
SGTC_1791 st048313 56.1 µM 1.06114221850074 0.133384473013344 no 500 0.1443126369231 682 1204976
SGTC_1607 st000305 50.6 µM 1.05780384078492 0.134104918146987 no 501 0.145072440712076 755 5457690
SGTC_2972 9093619 59.92 µM 1.05548176855771 0.134607611158362 no 502 0.145602521673357 722 25236256
SGTC_2969 9091408 28.7 µM 1.05528268277202 0.134650770293961 no 503 0.145648029369679 707 4286311
SGTC_3072 9116419 49.47 µM 1.05307623198023 0.135129735235358 no 504 0.146153027563248 659 17170162
SGTC_844 0330-0132 15.3 µM 1.05173810346346 0.135420777677843 no 505 0.146459862009454 797 2828079
SGTC_1111 tnp00062 510.699 nM 1.04940000147561 0.135930344438465 no 506 0.146997028769448 783 676306
SGTC_3217 9129673 49.47 µM 1.0476883630538 0.136304210809722 no 507 0.147391105390486 712 17248312
SGTC_775 4577-0580 57.3 µM 1.04685584582359 0.136486308326251 no 508 0.147583034476056 754 2006902
SGTC_3333 9141820 12.094 µM 1.04537349242869 0.13681095705834 no 509 0.147925191498101 698 1939433
SGTC_2840 9008771 71.43 µM 1.04445007793572 0.137013459762376 no 510 0.148138602385398 703 2992978
SGTC_2443 5493264 126.67 µM 1.04084495919696 0.137806014221054 no 511 0.148973755080405 759 5340055
SGTC_1176 0848-0131 83.3 µM 1.03649084924783 0.138767390871555 no 512 0.149986603153045 815 6769040
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.0335061698074 0.13942903345491 no 513 0.150683542345952 761 390807
SGTC_3021 9087658 49.47 µM 1.03191729005497 0.139782129579574 no 514 0.151055432752159 755 25237042
SGTC_3303 9125618 40.5795 µM 1.03162715534309 0.139846671679112 no 515 0.151123407062595 836 22695467
SGTC_2324 6149169 200 µM 1.03140285803885 0.13989658175765 no 516 0.151175970579564 730 2888231
SGTC_1972 st070201 17.4 µM 1.0300682581735 0.140193803909745 no 517 0.151488982218714 778 2829099
SGTC_1531 st059297 52.4 µM 1.02996640467677 0.140216504803499 no 518 0.151512888209536 788 7566702
SGTC_308 4092-1169 104 µM 1.02834128251697 0.140579046362887 no 519 0.151894659198543 810 2268590 YDL196W YDL196W
SGTC_1815 st051655 58.2 µM 1.02732919009055 0.140805150983166 no 520 0.152132740926342 757 5984156
SGTC_2941 9056145 11.23 µM 1.02611500856119 0.141076728341356 no 521 0.152418688311492 698 2119517
SGTC_1730 st033808 45.1 µM 1.02484198025263 0.141361849247957 no 522 0.152718877299104 844 1045166
SGTC_1731 st035964 63 µM 1.02266314746341 0.141850749460583 no 523 0.153233570715231 745 6739575
SGTC_973 1325-0077 65.9 µM 1.02256510294047 0.141872776195815 no 524 0.153256758215072 845 2835149
SGTC_1700 st030840 7.9285 µM 1.02136609705502 0.142142332849674 no 525 0.15354051080303 818 5499307
SGTC_2643 anethole 100 µM 1.02122213789723 0.142174720577078 no 526 0.153574603059059 819 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2025 5147754 141 µM 1.02034743134231 0.14237161817706 no 527 0.153781857898437 777 315777 YLR208W SEC13
SGTC_2795 7780010 54.55 µM 1.01880757282795 0.142718690395265 no 528 0.154147164916984 734 953673
SGTC_2125 5246583 200 µM 1.01724074556704 0.143072427820985 no 529 0.154519458549226 879 835267
SGTC_2207 7258803 200 µM 1.01279497510389 0.144079357454623 no 530 0.155579050677898 742 3666799
SGTC_305 1682-2595 20.8 µM 1.01271058360694 0.144098517522579 no 531 0.155599210548413 812 226033
SGTC_1784 st039334 36.3 µM 1.01181408203169 0.144302163423682 no 532 0.155813477784462 771 3496984
SGTC_1681 tripelennamine 100 µM 1.0114568214871 0.144383371405992 no 533 0.155898918577389 721 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_966 1300-0360 30.2 µM 1.00862455750895 0.145028255955729 no 534 0.156577362644247 779 70588
SGTC_1959 st077091 55.8 µM 1.0053912450979 0.145766822780703 no 535 0.157354246934957 808 821356 YKL052C ASK1
SGTC_355 1311-2252 105 µM 1.00327674521135 0.146251190732145 no 536 0.157863676543274 773 5338538
SGTC_3212 9128307 49.47 µM 1.00273883616211 0.146374581681722 no 537 0.157993443298083 677 27243542
SGTC_766 1391-0721 126 µM 1.00119194516051 0.146729812411674 no 538 0.158367009985269 809 1020919 YIL115C NUP159
SGTC_867 0518-0118 155 µM 0.998735580670305 0.147295083808482 no 539 0.158961399818811 809 6848158
SGTC_1060 3448-7350 82 µM 0.995818826654917 0.147968195595544 no 540 0.159669090560514 806 570178
SGTC_63 0099-0242 26.702 µM 0.992051582740162 0.148840621133706 no 541 0.160586181666986 858 3898502 YLR359W ADE13
SGTC_2076 5212012 200 µM 0.987623522978346 0.149870465917132 no 542 0.161668530766131 725 604802
SGTC_550 4123-0385 25.7 µM 0.986367129815231 0.150163531822435 no 543 0.161976494461526 802 5731123
SGTC_2687 chenodiol 100 µM 0.98214905118344 0.151150232045717 no 544 0.163013211651999 765 5702181 A cholesterol synthesis inhibitor.
SGTC_2561 acetosyringone 100 µM 0.98204667436913 0.151174233701096 no 545 0.163038427271525 928 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3308 9128332 17.569 µM 0.981001193442137 0.151419485847137 no 546 0.163296076511378 896 17332805 YDL196W YDL196W
SGTC_1767 st044992 70.3 µM 0.97967384489791 0.151731240348413 no 547 0.163623570367125 793 9600693
SGTC_787 4152-0075 138 µM 0.979648952989532 0.151737090785478 no 548 0.163629715964948 804 9566539
SGTC_2211 7117706 200 µM 0.978364163490025 0.152039263160315 no 549 0.163947122917863 787 822771
SGTC_1378 2093-0007 380 nM 0.97790776760321 0.152146700017023 no 550 0.164059971516875 803 3618014
SGTC_1749 st037932 54.2 µM 0.977561571543134 0.152228229144562 no 551 0.164145605669832 776 594497
SGTC_1226 3909-7979 35.4 µM 0.977339996385744 0.15228042528593 no 552 0.164200429134634 861 6615510
SGTC_232 clozapine 119 µM 0.977081435385071 0.15234134914904 no 553 0.164264418872237 822 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3283 9109332 35.8195 µM 0.976993752244273 0.152362013307163 no 554 0.164286122726935 735 17027281
SGTC_128 0906-2981 13.371 µM 0.976822414874678 0.152402397505049 no 555 0.164328538542417 758 6740226
SGTC_1248 0469-0687 58.6 µM 0.975930620434292 0.152612708060956 no 556 0.164549423402612 834 4017482
SGTC_685 1278-0033 54.9 µM 0.974785620661303 0.152883013831011 no 557 0.164833305627259 850 3590572
SGTC_1649 st011737 51.3 µM 0.974664474039586 0.152911632074393 no 558 0.164863360312677 811 1761035
SGTC_3194 9111903 49.47 µM 0.974060968838352 0.153054249915447 no 559 0.165013133904879 799 17087251
SGTC_2329 6138490 200 µM 0.972828396418515 0.153345800158386 no 560 0.165319298500367 708 720019
SGTC_3229 9132204 49.47 µM 0.97282006368204 0.15334777241866 no 561 0.165321369558984 827 17682924
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.972691227576656 0.153378268541212 no 562 0.165353393244117 871 165506
SGTC_2651 TUB2.036 5 µM 0.969450920406287 0.154146585920125 no 563 0.166160128323823 998 15992207 YFL037W TUB2
SGTC_3100 9120536 49.47 µM 0.968173608583296 0.154450150908124 no 564 0.166478836498431 728 16421196
SGTC_993 3909-8757 62.7 µM 0.967943409736456 0.154504901798566 no 565 0.166536316455537 762 4288324 YLR208W SEC13
SGTC_1037 k284-1091 78.7 µM 0.967182005365914 0.154686086910161 no 566 0.166726528077624 769 3334711
SGTC_3071 9117417 49.47 µM 0.96634807604043 0.154884691216279 no 567 0.166935018436565 734 45595590 YGL055W OLE1
SGTC_2597 laccaic acid a 100 µM 0.966202242104542 0.154919439568841 no 568 0.166971495591562 830 5491415 A textile dye.
SGTC_290 2043-6722 48.1 µM 0.963953246217444 0.155455967485001 no 569 0.16753468333902 834 773758 YLR208W SEC13
SGTC_2260 7964312 200 µM 0.963467951452317 0.15557190163715 no 570 0.167656369937719 792 231951
SGTC_1600 coumarin 106 71.1 µM 0.961261295641118 0.156099778212195 no 571 0.168210401722492 875 100336 A hepatotoxic, DNA x-linker.
SGTC_302 1094-0063 18.9 µM 0.960374018806267 0.156312365049027 no 572 0.168433504648169 772 5440289
SGTC_624 k048-0052 28 µM 0.959161796032437 0.156603115321083 no 573 0.168738621614861 802 6835531
SGTC_2161 5662504 8.5105 µM 0.953392312410705 0.157991796121698 no 574 0.170195667513437 789 2859334
SGTC_1228 0124-0032 52.5 µM 0.952081304717355 0.158308471805284 no 575 0.170527874789316 886 X1228
SGTC_1116 jasmonic acid 1.58368 µM 0.951546235848459 0.15843783800691 no 576 0.170663579625438 854 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1861 st057647 17.4 µM 0.949882806877399 0.158840456080989 no 577 0.171085901940048 857 688668
SGTC_3322 9139058 2.11 µM 0.945740947567634 0.159845867129751 no 578 0.172140365867857 867 4908926 YPR165W RHO1
SGTC_1994 st072947 40.9 µM 0.944639587693663 0.160113914650829 no 579 0.17242145451356 859 5286565 YDL195W SEC31
SGTC_2663 amphotericin b 100 µM 0.944285974317311 0.160200038899571 no 580 0.172511765638533 830 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_413 propylparaben 100 µM 0.941133510336007 0.160969174864163 no 581 0.173318222359952 847 7175 A pharmaceutical preservative.
SGTC_1428 4049-0204 61.7 µM 0.940391690446088 0.161150513296301 no 582 0.173508341476849 901 X1428
SGTC_1162 k048-0130 20.1 µM 0.938977660009165 0.161496543143508 no 583 0.173871107181537 849 6797406
SGTC_2282 7944268 200 µM 0.936982520538272 0.161985600579177 no 584 0.17438377461602 873 2970414
SGTC_2456 5770359 74.46 µM 0.936245717905741 0.162166452571031 no 585 0.174573344647918 901 3118787
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.936155942341194 0.162188497427123 no 586 0.17459645171022 707 6708630 An antioxidant.
SGTC_250 brefeldin a 552.239 µM 0.934816472695249 0.162517642886631 no 587 0.174941444412234 770 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_199 4063-0024 41.6 µM 0.932534117479893 0.163079482468422 no 588 0.175530281667488 901 306215
SGTC_2762 leflunomide 42.06 µM 0.930988742269138 0.16346061814511 no 589 0.175929693795973 900 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_661 1304-0007 33.6 µM 0.929125757139603 0.163920854382875 no 590 0.176411958717112 846 3117130
SGTC_1758 st042942 75.2445 µM 0.929051531290153 0.163939208713064 no 591 0.176431190630931 866 669317
SGTC_2064 5220758 200 µM 0.92744012761809 0.164338000146203 no 592 0.176849032148483 902 788518
SGTC_1306 1185-0270 9.02 µM 0.926403919800307 0.164594773642562 no 593 0.177118053900943 911 1548076
SGTC_1178 0988-0033 191 µM 0.926293394221854 0.164622177344996 no 594 0.17714676395919 872 5392207
SGTC_375 3970-0961 9.27 µM 0.92618636999811 0.164648715739087 no 595 0.177174567308886 884 2898222
SGTC_3026 9090633 49.47 µM 0.925816060921864 0.164740561275221 no 596 0.177270789531818 893 25236842
SGTC_2669 eugenol 100 µM 0.923939466158092 0.165206511976087 no 597 0.177758916779061 828 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_130 0136-0219 337.655 µM 0.921922125567714 0.165708359661767 no 598 0.1782845986377 889 234244
SGTC_772 k072-0172 35.3 µM 0.920325348148724 0.166106283247666 no 599 0.178701383322665 813 5861980
SGTC_2160 5660466 132.927 µM 0.920079807965459 0.166167527603447 no 600 0.178765527651808 844 2859134
SGTC_2489 cantharidin 73.42 µM 0.919471233204947 0.166319385463753 no 601 0.178924572738401 866 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1174 0739-0097 51.1 µM 0.917447353955189 0.166825049108761 no 602 0.179454134114974 874 728447
SGTC_1245 0418-0076 17.2 µM 0.916064894377954 0.167171024382993 no 603 0.179816429569829 874 6790114
SGTC_1911 st060208 74.3 µM 0.914753065469024 0.167499750982798 no 604 0.180160639664454 908 688783
SGTC_1980 st071811 45.7 µM 0.913395254942426 0.167840438250836 no 605 0.180517350134161 887 4974850
SGTC_2879 9041815 71.43 µM 0.911935394060769 0.168207228217156 no 606 0.180901364083493 814 4942971
SGTC_2083 5306046 65.942 µM 0.911788985773742 0.168244041721578 no 607 0.180939904764973 879 539837
SGTC_2863 9028737 58.44 µM 0.911768154417277 0.168249280065041 no 608 0.18094538885271 902 6460917
SGTC_3351 9150312 21.596 µM 0.9113885397232 0.168344758002812 no 609 0.181045344913738 875 4904905
SGTC_554 4483-2211 187 µM 0.908674164065162 0.169028473243838 no 610 0.181761072858287 875 747107
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.905039495597584 0.169946786907232 no 611 0.182722231902861 936 6708739 YPR165W RHO1
SGTC_1523 st012844 44.7 µM 0.90345165716605 0.170348962627768 no 612 0.183143117185898 890 4274103
SGTC_1633 st005664 67.9 µM 0.901651562241332 0.170805636435624 no 613 0.18362099563813 924 2063822
SGTC_261 5-fluorouridine 15.376 µM 0.895181656832866 0.172453475739048 no 614 0.185344994335538 914 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2098 5376439 882.5 nM 0.892443890762479 0.173153808347357 no 615 0.186077527291353 960 2844116
SGTC_3208 9114115 49.47 µM 0.89198475263779 0.173271435014221 no 616 0.186200552509153 817 650895
SGTC_1500 4488-1866 171 µM 0.888693225763933 0.174116181057271 no 617 0.187083986386166 997 2900003
SGTC_1349 flufenamic acid 69 µM 0.88755275143826 0.174409484989409 no 618 0.18739068935896 887 3371 A non-steroidal anti-inflammatory.
SGTC_2320 7373003 200 µM 0.886655425961065 0.174640477085704 no 619 0.187632221674192 935 5415828
SGTC_1056 3448-1962 115 µM 0.884818045367482 0.175114066644955 no 620 0.188127387594986 883 715507
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.884331526270373 0.175239604478528 no 621 0.188258637259282 909 6708514
SGTC_824 1304-0008 100 µM 0.881742867058299 0.175908522569754 no 622 0.188957936956597 927 768245
SGTC_1642 st009582 77.7 µM 0.88144143096351 0.175986519626932 no 623 0.189039470714629 912 6739311
SGTC_1921 5740136 50 µM 0.881070416273584 0.176082550311629 no 624 0.189139854141374 971 1774243
SGTC_926 2268-1401 59.4 µM 0.880930126594051 0.176118870491222 no 625 0.189177820108325 956 2931578
SGTC_2522 biochanin a 4.94 µM 0.878546991372685 0.17673657468415 no 626 0.189823474050411 924 5280373 A possible chelator.
SGTC_1671 st016596 74.5 µM 0.876251991600029 0.177332727288754 no 627 0.190446528868785 983 2829167
SGTC_944 3370-0224 231 µM 0.876233025940629 0.177337659120909 no 628 0.190451682960689 930 4580514
SGTC_3083 9117465 49.47 µM 0.874446506138461 0.177802614197963 no 629 0.190937570085981 980 16420915
SGTC_2311 7694451 200 µM 0.873307253710151 0.178099514291368 no 630 0.19124781394028 907 2163142
SGTC_1903 st060211 78.3 µM 0.871740496424536 0.17850833638958 no 631 0.191674981276831 993 688960
SGTC_2862 9027634 71.43 µM 0.869541609556369 0.179083099402435 no 632 0.192275479713872 856 5012562
SGTC_2598 perillyl alcohol 100 µM 0.868825915402289 0.179270424253079 no 633 0.192471178010759 953 10819 An apoptosis inducer.
SGTC_433 pimozide 108 µM 0.868348689537319 0.179395401178675 no 634 0.192601737555436 845 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.868272115421308 0.179415459669901 no 635 0.192622691755314 1020 551469
SGTC_1059 3448-6867 171 µM 0.868192064659858 0.179436430371348 no 636 0.19264459881483 971 3934407
SGTC_1294 1000-1494 117 µM 0.868049108418168 0.179473884099866 no 637 0.192683724664736 918 712797 YDL207W GLE1
SGTC_2340 7987427 183.45 µM 0.867744984925514 0.179553579084953 no 638 0.19276697670771 892 2239331
SGTC_1100 amiodarone 5.07 µM 0.865897963265502 0.180038065219117 no 639 0.193273060070716 1002 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1756 st041558 35.5 µM 0.865670385984439 0.180097817007528 no 640 0.193335472236785 1036 3955792
SGTC_1325 1431-0015 227 µM 0.864717542664672 0.180348126931275 no 641 0.193596919251423 889 1103340
SGTC_453 enantio-paf c16 10 µM 0.864596725191865 0.180379881012421 no 642 0.193630085289554 1015 13871343 A lipid and platelet activating factor
SGTC_1213 1315-0166 115 µM 0.863218733216223 0.180742302497806 no 643 0.194008607894221 828 768401
SGTC_59 0330-0160 1.33 µM 0.860047744068822 0.181578027245218 no 644 0.194881362385406 1041 4293482
SGTC_1660 st012960 28.1 µM 0.859496005023022 0.181723686526872 no 645 0.195033461566726 923 24207266
SGTC_339 3091-4833 71.4 µM 0.857478466004989 0.182256939628812 no 646 0.195590255378568 946 3240077
SGTC_3216 9129716 49.47 µM 0.855251427730178 0.18284669943393 no 647 0.196205985531667 900 8056934
SGTC_338 4055-0136 114 µM 0.8548171359875 0.182961846340178 no 648 0.196326195046765 985 2900563
SGTC_3345 9148410 3.559 µM 0.854186517266287 0.183129127371919 no 649 0.196500826227465 955 4903596
SGTC_210 3551-0445 56.827 µM 0.853744628531084 0.183246401786928 no 650 0.196623250295475 961 2865180 YOR207C RET1
SGTC_2946 9065502 71.43 µM 0.85306210063095 0.183427632296799 no 651 0.196812433563198 802 16489101
SGTC_1924 st058459 75.1 µM 0.852767933125376 0.183505776555225 no 652 0.196894004970899 962 688683
SGTC_2337 9009472 200 µM 0.85236875879913 0.183611848574636 no 653 0.197004727053585 970 5742383
SGTC_2235 salicylic acid 500 µM 0.851937856511046 0.183726394493601 no 654 0.197124292057515 979 338 A COX inhibitor and kinase inhibitor.
SGTC_2539 epi(13)torulosol 80 µM 0.85182332928015 0.183756846532244 no 655 0.197156077989882 945 6708597
SGTC_60 0986-0278 202 µM 0.851707535657412 0.183787638492596 no 656 0.19718821854985 868 3110598
SGTC_1230 0170-0365 3.77 µM 0.850774668559158 0.184035824717355 no 657 0.197447267876759 1090 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2929 9013348 24.6 µM 0.850304899048424 0.184160884309376 no 658 0.197577796778831 937 2995952
SGTC_2432 5630864 12.22 µM 0.849274823490724 0.184435290758816 no 659 0.197864193356598 927 5714970
SGTC_2721 ifenprodil 61.44 µM 0.849232010424442 0.184446701426324 no 660 0.197876102293598 955 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1390 3413-2614 145 µM 0.848549386723905 0.184628695668947 no 661 0.198066040256756 1022 3421432
SGTC_1251 0490-5699 265 µM 0.847968394164436 0.184783681971844 no 662 0.198227786359794 1050 3883818
SGTC_1496 4469-0713 57.4 µM 0.847760618451732 0.184839128107912 no 663 0.198285649672363 959 746691
SGTC_2128 5255449 168.493 µM 0.846270412034333 0.185237101182349 no 664 0.19870095489396 1033 736008
SGTC_880 0833-0487 87.2 µM 0.842424026605451 0.186266769930213 no 665 0.199775324454359 950 76075
SGTC_2239 6685329 187.64 µM 0.841136671351328 0.186612182666078 no 666 0.200135686630638 956 805680
SGTC_1569 carminic acid 40.6 µM 0.841038126343233 0.186638639796221 no 667 0.200163287874501 1009 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3225 9130819 49.47 µM 0.83910824063835 0.187157238932416 no 668 0.200704286102918 996 4547121
SGTC_2963 9082507 9 µM 0.838991821054317 0.187188551693848 no 669 0.200736949652299 917 16459611
SGTC_2116 5511452 16.8835 µM 0.837986143412286 0.187459178358398 no 670 0.201019242904368 982 870744
SGTC_273 hydroxyurea 18.1 mM 0.836844166020065 0.187766776158413 no 671 0.201340084000602 1041 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3314 9135860 59.4275 µM 0.834548888772826 0.188385963820505 no 672 0.201985875036578 1021 25252478
SGTC_2898 9056270 58.44 µM 0.834426729459301 0.18841895350567 no 673 0.202020280059065 952 19154699
SGTC_2480 5767542 37.17 µM 0.833920234643791 0.188555772772909 no 674 0.202162966978028 1014 2867358
SGTC_1920 st075728 45.7 µM 0.833431411121884 0.188687876574048 no 675 0.202300732800259 976 3400306
SGTC_1874 staurosporine 7.6 µM 0.832249219162847 0.189007597877544 no 676 0.20263414365929 1024 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_275 trichlorophene 5.69 µM 0.832235032581855 0.189011436633468 no 677 0.202638146660995 1077 62616
SGTC_2462 5162487 171.77 µM 0.830984531607043 0.189349999155035 no 678 0.202991183906148 1017 2259986
SGTC_2044 5102272 200 µM 0.830462115464308 0.189491549368924 no 679 0.203138779391068 928 592666
SGTC_3157 9099274 49.47 µM 0.827811298063062 0.190210799236885 no 680 0.203888687637352 998 17217662
SGTC_468 gf-109203x 121 µM 0.82506431711408 0.190957908376044 no 681 0.204667538354136 914 2396 A protein kinase C inhibitor.
SGTC_247 mechlorethamine 29.705 µM 0.823669057972369 0.191338071828947 no 682 0.205063812660666 964 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3050 9093513 49.47 µM 0.822348819387679 0.191698221369747 no 683 0.205439199599924 1063 25236664
SGTC_3089 9117425 49.47 µM 0.821712628003668 0.191871916941499 no 684 0.205620235190021 962 9401657
SGTC_3131 9127911 49.47 µM 0.821519288480396 0.191924722371248 no 685 0.205675270936283 955 45595681
SGTC_3004 9076122 71.4286 µM 0.821159250069067 0.192023080769795 no 686 0.205777782241911 1010 44782551
SGTC_154 3389-1638 511.116 µM 0.820346490860745 0.192245230730223 no 687 0.206009305123587 936 5238686
SGTC_2269 7935389 174.42 µM 0.818543655101855 0.192738557253241 no 688 0.206523412647621 970 97605
SGTC_259 usnic acid 108.925 µM 0.818277208504669 0.192811533036398 no 689 0.206599458576576 1045 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_731 3966-0296 387 µM 0.817066700094192 0.193143285886826 no 690 0.206945155849532 1026 660956
SGTC_767 0929-0023 86 µM 0.81656255646061 0.193281554594363 no 691 0.207089230217361 1087 1204563
SGTC_2546 rhodinyl acetate 100 µM 0.814083455700257 0.193962362452124 no 692 0.207798571490876 1035 6708682
SGTC_2883 9059145 45.46 µM 0.811925743517441 0.194556098766777 no 693 0.208417120808592 1008 16476510
SGTC_1793 st048256 72.231 µM 0.810331540354587 0.194995484345887 no 694 0.208874826279053 996 672022
SGTC_67 0335-0847 266 µM 0.810044252904023 0.195074729054174 no 695 0.208957371191303 1090 4552207 YOR254C SEC63
SGTC_2746 daunorubicin 9.88 µM 0.807778043466663 0.195700521081249 no 696 0.209609183488885 915 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3105 9121040 49.47 µM 0.807257897242667 0.195844326244772 no 697 0.209758957684703 846 41448907
SGTC_426 0988-0037 14.6 µM 0.806713991609452 0.195994768754313 no 698 0.209915640592695 1061 5383008
SGTC_940 3232-1287 54.8 µM 0.805394783412578 0.196359948523595 no 699 0.210295950546567 1035 1585493 YIL048W NEO1
SGTC_369 0957-0393 4.5 µM 0.803784895163773 0.196806151915912 no 700 0.210760607346704 1022 6997992
SGTC_405 ebelactone b 50 µM 0.803397230614629 0.19691369030804 no 701 0.210872587602476 1012 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1483 3453-0561 55.9 µM 0.803332862932806 0.196931549386971 no 702 0.210891184140575 1030 4546991
SGTC_463 ikarugamyin 104 µM 0.802452764296694 0.197175834734282 no 703 0.211145550861244 1065 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_3036 9090181 49.47 µM 0.802354533379259 0.197203111654145 no 704 0.211173952778904 1020 25236586
SGTC_2144 5628481 200 µM 0.79947363050986 0.198004100360527 no 705 0.212007915481122 1033 2818399
SGTC_801 0866-0028 10.1 µM 0.799357603615989 0.198036400878846 no 706 0.212041543203924 1067 6849771
SGTC_1724 st037281 8.293 µM 0.799186419057904 0.198084062450332 no 707 0.212091162800791 1031 574124 YDL195W SEC31
SGTC_897 1000-0139 31.4 µM 0.798892090134713 0.198166026330466 no 708 0.212176492923332 1036 6151020
SGTC_268 camptothecin 39.6153 µM 0.798554114220849 0.198260170150877 no 709 0.212274501677241 1078 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2246 7293507 91.5585 µM 0.798021112915453 0.1984086935027 no 710 0.212429119092778 1081 887656
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.797473067706177 0.198561478893651 no 711 0.212588169158979 1049 2333 A French combination drug.
SGTC_1194 1488-0194 225 µM 0.795823199417353 0.199021861448626 no 712 0.213067402700777 1046 1391452
SGTC_306 1672-3436 11.6 µM 0.79458565519136 0.19936761006986 no 713 0.213427282697957 1074 6797378
SGTC_196 k015-0023 18.111 µM 0.793940007028653 0.199548136555085 no 714 0.213615178854908 1049 5211998
SGTC_1057 3448-5381 134 µM 0.793847249966494 0.199574079977778 no 715 0.213642180877134 1067 5497911
SGTC_1261 0712-0010 12.7 µM 0.792399117455671 0.199979374451818 no 716 0.214063996929386 1073 2840123
SGTC_945 3381-0768 11.3 µM 0.791153059452075 0.200328509355419 no 717 0.214427339825447 1094 1126236 YIL048W NEO1
SGTC_1265 0819-1001 68.8 µM 0.790311374277764 0.200564549508915 no 718 0.214672972881046 1049 3106768
SGTC_349 k015-0014 24 µM 0.789922494323612 0.200673662443357 no 719 0.21478651680694 998 2196908
SGTC_1326 1431-2094 10.8 µM 0.788766352348267 0.200998266118805 no 720 0.215124289442815 1043 616278
SGTC_1243 0416-0003 5.65 µM 0.787059332361276 0.201478112261112 no 721 0.215623567180145 1041 2141977
SGTC_829 1635-0120 117 µM 0.783296807379284 0.202538185350639 no 722 0.216726418802872 1109 285054
SGTC_565 1418-0001 44.5 µM 0.781952511188212 0.202917741244448 no 723 0.217121241436799 1093 2862145
SGTC_2822 7994718 71.43 µM 0.780942963472227 0.203203061560073 no 724 0.217418020768207 984 1018011
SGTC_1912 st060209 90.8 µM 0.779039727132158 0.203741608700409 no 725 0.217978156544113 1033 688787
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.778490688268259 0.203897124864974 no 726 0.21813989702273 1100 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2920 7982904 15.77 µM 0.777323927856205 0.204227846493012 no 727 0.218483840682149 1016 6456808
SGTC_619 1652-1634 108 µM 0.776122286698744 0.204568788862397 no 728 0.218838392881474 995 5400454
SGTC_104 0074-0074 590.992 µM 0.775835685671886 0.204650156338652 no 729 0.218923005285048 946 3943124
SGTC_1505 k297-0037 20.6 µM 0.775639936835845 0.204705741484568 no 730 0.21898080647015 1060 4089396
SGTC_526 4469-0568 170 µM 0.770217890662966 0.206248960934565 no 731 0.220585326536335 1079 2901964
SGTC_1362 1611-0397 101 µM 0.770193889034882 0.206255807557923 no 732 0.220592444164701 1099 27816
SGTC_2899 9053889 58.44 µM 0.769712513717313 0.206393151498206 no 733 0.220735222703281 1062 6470052
SGTC_2166 5933061 31.504 µM 0.769709445887564 0.206394026971977 no 734 0.220736132807973 1270 2877375
SGTC_537 1334-0398 209 µM 0.767938398379718 0.206899802175217 no 735 0.221261891719515 1100 5846986
SGTC_863 0466-0191 129 µM 0.76671420834581 0.207249834361087 no 736 0.221625727029692 1116 765160 YPR165W RHO1
SGTC_1392 3455-1037 33.9 µM 0.766433986631956 0.207330007276506 no 737 0.2217090583662 1073 981132
SGTC_820 1582-0060 59.9 µM 0.765323916194586 0.207647784460006 no 738 0.222039343033516 1054 3848840
SGTC_2958 9077254 16.72 µM 0.763574756720354 0.208149095676431 no 739 0.222560348571333 1104 16457351
SGTC_2360 9040895 200 µM 0.758318210028878 0.209659920372159 no 740 0.224130254179668 1044 4914414
SGTC_192 3455-0609 60.9 µM 0.75777676199975 0.209815907632453 no 741 0.224292318055399 1129 3769639
SGTC_2779 methotrexate 400 µM 0.755156341342933 0.210571795347313 no 742 0.225077590454187 1193 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_779 1360-0071 233 µM 0.75435270480397 0.210803932502849 no 743 0.225318731342422 1171 7566
SGTC_1646 st011709 75.6 µM 0.754296630929199 0.210820135511714 no 744 0.225335562446842 1090 5757843
SGTC_3344 9148862 3.898 µM 0.753593162260774 0.211023470640584 no 745 0.225546775708795 1118 4905352
SGTC_1001 4048-4355 44.4 µM 0.752378114169327 0.211374946629704 no 746 0.225911852124917 1088 21824233
SGTC_2015 5119600 184 µM 0.75200676422632 0.211482435102673 no 747 0.226023495494652 1100 2828786
SGTC_3118 9124250 49.47 µM 0.750761439776365 0.211843131959928 no 748 0.226398119841297 998 1504786
SGTC_138 0850-0259 40.9225 µM 0.742593954357521 0.214217675201792 no 749 0.228863774920801 1158 6813004
SGTC_1896 st058441 89 µM 0.742345089276522 0.21429027032957 no 750 0.228939139837914 1052 688759
SGTC_1282 0886-0010 32.4 µM 0.741808128753738 0.214446953007198 no 751 0.229101797407674 1192 2836211 YNL267W PIK1
SGTC_2109 5483026 200 µM 0.741333859333493 0.214585398087534 no 752 0.229245518311401 1127 759335
SGTC_630 4356-0227 183 µM 0.73960972461077 0.215089131768133 no 753 0.229768419632196 1137 779312
SGTC_2060 5238662 140 µM 0.73816114841986 0.215512886812997 no 754 0.230208264459127 1081 790130
SGTC_2179 6298986 200 µM 0.737411038402441 0.215732508228136 no 755 0.230436212379162 1068 738374
SGTC_1971 st069429 63.5 µM 0.73724622785441 0.215780779762719 no 756 0.230486312896299 1130 1246522 YGL099W LSG1
SGTC_379 3970-0972 5.9 µM 0.734910301043796 0.216465624712027 no 757 0.231197062198896 1110 2898042 YBL034C STU1
SGTC_974 1326-0144 138 µM 0.734855891248443 0.216481591502764 no 758 0.231213631954525 1158 5411856
SGTC_2271 7849410 118.62 µM 0.734475904509574 0.21659311925894 no 759 0.231329370164218 1141 972430
SGTC_2913 7966556 36.57 µM 0.731234621950246 0.217545799817762 no 760 0.232317928077406 1082 2976516
SGTC_3090 9117696 49.47 µM 0.728917402706147 0.218228358935978 no 761 0.233026094420882 1122 7923821
SGTC_2407 paclitaxel 400 µM 0.727433690364396 0.218666047871645 no 762 0.233480161153583 1140 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1632 st005650 90 µM 0.727244359134793 0.218721936123234 no 763 0.233538138273954 1122 2759605
SGTC_412 gemfibrozil 100 µM 0.727109934298117 0.218761621672662 no 764 0.233579306772801 1140 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2026 5148700 152 µM 0.723764585968875 0.219750585481451 no 765 0.234605137201742 1147 79838
SGTC_2371 9071574 200 µM 0.722567793535097 0.220105007926988 no 766 0.234972730461491 1137 45596039
SGTC_2723 salbutamol 83.58 µM 0.720962506891428 0.220580917793225 no 767 0.235466291513318 1113 9884233 β2-adrenoceptor agonist
SGTC_2357 9067248 200 µM 0.720335257549651 0.220767034774073 no 768 0.23565930077757 1140 9150235
SGTC_1922 5578187 25 µM 0.719797231968809 0.220926748971591 no 769 0.235824924729646 1140 1350412
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.719362329083969 0.221055899275145 no 770 0.235958850632823 1118 688662
SGTC_746 1095-0025 46.6 µM 0.718728727427516 0.221244133173908 no 771 0.236154039702658 1172 6749286
SGTC_2059 5238311 157 µM 0.71869819856231 0.221253205173363 no 772 0.236163446754294 1166 703021
SGTC_1414 3917-0015 5.4 µM 0.716724372493012 0.221840201473566 no 773 0.236772092103531 1152 6618702
SGTC_2051 5263410 176 µM 0.716328674386713 0.221957985109816 no 774 0.236894212558923 1242 227584
SGTC_2902 5787006 60.46 µM 0.716269385063622 0.221975636265886 no 775 0.23691251342815 1138 591003
SGTC_599 1935-0052 86.5 µM 0.71467914513433 0.222449369079178 no 776 0.237403663578437 1169 9557311
SGTC_2123 5259487 200 µM 0.713378541855341 0.222837247340579 no 777 0.237805773840257 1147 2173474
SGTC_1144 3486-0183 12.5 µM 0.713165178922448 0.222900915234261 no 778 0.237871775356718 1179 6744069
SGTC_1856 st057054 55.7 µM 0.712476832626762 0.223106389673279 no 779 0.238084776303781 1201 1266018
SGTC_3232 9132874 49.47 µM 0.712303142855551 0.223158253879481 no 780 0.238138539142732 1157 3784940
SGTC_1816 st051957 91.6 µM 0.710019234842336 0.223840872835763 no 781 0.238846104170018 1169 674121
SGTC_894 0960-0238 55.9 µM 0.709727367776455 0.223928192083108 no 782 0.238936608695778 1165 6741907 YDL195W SEC31
SGTC_567 1080-0542 68.4 µM 0.708809947300702 0.224202787099731 no 783 0.239221212011578 1111 5950415
SGTC_1863 st057641 20.1 µM 0.708627158305375 0.22425752088615 no 784 0.239277939161411 1198 3921635
SGTC_3116 9124943 49.47 µM 0.708263609099538 0.22436640351225 no 785 0.239390785683943 1100 41905195 YPL160W CDC60
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.707263029126356 0.224666231114756 no 786 0.239701518077872 1180 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_601 0986-0029 62.9 µM 0.707115555769834 0.22471044127602 no 787 0.239747334869088 1173 24747981
SGTC_1108 betulinic acid 729.144 nM 0.705865623808519 0.225085349020754 no 788 0.240135853589614 1205 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3013 9080133 71.4286 µM 0.705419370137941 0.22521928527696 no 789 0.240274646553497 1244 17050193
SGTC_653 0203-0016 55.2 µM 0.705257792099115 0.225267791598674 no 790 0.240324911022595 1189 295302
SGTC_1672 st016598 6.51 µM 0.702911381536164 0.225972859164209 no 791 0.241055488888293 1142 4665860 YNL267W PIK1
SGTC_2069 5228469 200 µM 0.702831203605585 0.225996973671864 no 792 0.241080474390299 1148 2835210
SGTC_605 1315-0399 119 µM 0.701624275006234 0.226360148152596 no 793 0.241456754410574 1222 24020461
SGTC_3324 9138759 60.749 µM 0.701161219204327 0.22649957279741 no 794 0.241601204368943 1198 45595710
SGTC_543 3844-1095 191 µM 0.699966583549759 0.226859497649817 no 795 0.241974086763137 1186 4230703
SGTC_533 1222-0222 6.71 µM 0.698869008293028 0.227190463926919 no 796 0.242316948589764 1240 3982874
SGTC_3192 9110362 49.47 µM 0.697103145992377 0.227723518284033 no 797 0.242869122760882 1248 16649480
SGTC_1909 st060837 51.5 µM 0.695792346170721 0.228119659417295 no 798 0.243279441585769 1152 678937
SGTC_2288 7946289 167.31 µM 0.694987317603357 0.228363141696983 no 799 0.243531624760649 1225 1246052
SGTC_1843 st055809 45.5 µM 0.692395923709112 0.229147904151013 no 800 0.24434436250707 1188 16413835
SGTC_1910 st062352 60.4 µM 0.691610199054423 0.229386146861502 no 801 0.244591077489697 1176 2245730
SGTC_11 0438-0307 1.3 µM 0.691589994317375 0.229392275050976 no 802 0.244597423480248 1200 4011476
SGTC_1404 3909-7820 48.3 µM 0.691377609753624 0.229456697815663 no 803 0.244664135500672 1182 23741373
SGTC_888 0916-0002 6.97 µM 0.691067823268113 0.229550683754428 no 804 0.244761459960817 1236 2802138 YIL048W NEO1
SGTC_1591 genipin 88.4 µM 0.690520706396533 0.229716725892034 no 805 0.244933396515546 1178 442424 A DNA cross-linking agent.
SGTC_2438 5259590 200 µM 0.689317709039017 0.230082054810286 no 806 0.245311678042232 1215 1201127
SGTC_1524 corynanthine 62.1 µM 0.689162579882328 0.230129188429857 no 807 0.245360481126682 1215 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1507 4075-3230 155 µM 0.688846515490334 0.230225236470028 no 808 0.245459930011944 1142 659771
SGTC_1292 0kpi-0043 232 µM 0.686493895692729 0.230940872548279 no 809 0.246200856180754 1199 3333905
SGTC_287 k060-0039 29.6 µM 0.68399015011071 0.231703841370027 no 810 0.246990692817938 1233 5861974
SGTC_3188 9110789 49.47 µM 0.683821972486198 0.231755140592505 no 811 0.247043795021485 1238 849217
SGTC_1412 3909-8563 178 µM 0.683154358125609 0.231958845413152 no 812 0.247254654961816 1274 23767530
SGTC_2457 5731572 11.68 µM 0.683076594229862 0.231982579485495 no 813 0.247279222238671 1246 2865357
SGTC_352 k048-0007 5.11 µM 0.682642645976759 0.232115048281504 no 814 0.247416339725543 1201 6811911
SGTC_2176 5809774 33.9695 µM 0.681872635786959 0.232350208310492 no 815 0.247659744904428 1214 2870539
SGTC_878 0828-0289 13.7 µM 0.681571885114321 0.232442093122075 no 816 0.247754848847966 1214 745350 YLR208W SEC13
SGTC_522 1273-0010 11.6 µM 0.681105458861167 0.232584634808696 no 817 0.247902381598897 1276 5705015
SGTC_1293 1000-1278 195 µM 0.680879548169013 0.232653691464655 no 818 0.247973855032628 1265 678847
SGTC_1139 k015-0024 46.9 µM 0.68044421987397 0.232786795284734 no 819 0.248111614835547 1215 2766652
SGTC_2780 5215298 71.43 µM 0.679938426010255 0.232941497435766 no 820 0.248271724750124 1223 2834131
SGTC_2765 myclobutanil 7.74 µM 0.676843113316084 0.233889473017609 no 821 0.249252750242348 1246 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2851 9015922 71.43 µM 0.676511613829181 0.233991125169504 no 822 0.249357937440144 1214 2996893
SGTC_2811 7967822 32.47 µM 0.67501488031401 0.234450393283969 no 823 0.249833155508057 1235 2232244
SGTC_836 0330-0104 1.35 µM 0.672670460956951 0.235170772592415 no 824 0.250578482032852 1247 46494820
SGTC_85 0868-0259 160.055 µM 0.672608832893273 0.235189725773659 no 825 0.250598090407744 1177 83173
SGTC_1750 st081859 2.357 µM 0.672372709211574 0.235262351389043 no 826 0.250673226068501 1246 5291695
SGTC_1833 st055984 71 µM 0.671596857690961 0.235501070667194 no 827 0.250920189639743 1243 676288
SGTC_3065 9113888 49.47 µM 0.671526504389794 0.235522724057253 no 828 0.250942590371551 1288 16648368
SGTC_1590 st077108 57.8 µM 0.671035397516503 0.235673907880757 no 829 0.251098989956194 1209 5489485
SGTC_720 r052-1644 49.9 µM 0.669183124800482 0.236244598450619 no 830 0.251689334793589 1220 1422863 YOR257W CDC31
SGTC_3183 9108214 49.47 µM 0.662635231305385 0.238268110651776 no 831 0.25378210019497 1169 4974831
SGTC_1558 st069300 45.6 µM 0.662519857437684 0.238303849848039 no 832 0.253819056447315 1207 24208000
SGTC_3237 9133362 49.47 µM 0.662303669100646 0.238370826101863 no 833 0.253888312929908 1197 43845137
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.661541412288262 0.238607059396878 no 834 0.254132582949548 1286 364106
SGTC_919 tnp00227 403.569 nM 0.661370965792522 0.23865990050489 no 835 0.254187220465961 1257 1269246 A methoxyflavone. YNL221C POP1
SGTC_3155 9099265 49.47 µM 0.660361521470638 0.238972975425151 no 836 0.254510929357489 1217 25236499
SGTC_1939 st074455 53.6 µM 0.65978932756128 0.239150538634163 no 837 0.254694516530575 1276 1644229
SGTC_1624 st003710 6.25 µM 0.659758072382997 0.239160239817213 no 838 0.254704546683681 1263 24207033
SGTC_3020 9089140 49.47 µM 0.658994115763991 0.239397428440061 no 839 0.254949773617541 1256 17217859
SGTC_715 0868-0130 184 µM 0.656277233533694 0.240241989507372 no 840 0.255822881578627 1311 2876258
SGTC_590 k048-0076 22.4 µM 0.655984615618622 0.240333048501039 no 841 0.255917011435361 1263 6832814
SGTC_2175 5807670 165.306 µM 0.654484411441495 0.240800188243693 no 842 0.256399883516075 1225 241186
SGTC_2073 5212005 126 µM 0.654177404217233 0.240895846276013 no 843 0.256498758698904 1157 691789
SGTC_396 dithiazanine 1.25 µM 0.652728547092022 0.241347563426446 no 844 0.256965647612087 1239 10578 An antihelmenthic.
SGTC_814 3342-0569 96 µM 0.651785604946028 0.241641796074142 no 845 0.257269744611837 1299 4346283
SGTC_2399 5884133 200 µM 0.651186476226475 0.241828847409489 no 846 0.25746305959456 1270 722445
SGTC_1214 0358-0031 63.7 µM 0.649957312367313 0.242212845054316 no 847 0.257859897922592 1352 4301366
SGTC_2768 sulfasalazine 50.2 µM 0.649421310062367 0.24238039859674 no 848 0.258033046805746 1334 5384001 An antioxidant and salicylic acid derivative.
SGTC_3226 9131256 49.47 µM 0.647882764791397 0.242861694265481 no 849 0.258530389491253 1179 17178073
SGTC_2737 bleomycin 30.5 nM 0.646693565396336 0.243234059807399 no 850 0.258915144207522 1294 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_3262 9137218 49.47 µM 0.646460226708198 0.243307159692802 no 851 0.258990673579959 1145 17650664
SGTC_3054 9094397 49.47 µM 0.645426383187348 0.243631182956336 no 852 0.259325455312243 1250 2598354
SGTC_588 3970-1144 52.9 µM 0.64412229275335 0.244040238086343 no 853 0.259748067752953 1212 1888707
SGTC_1140 3229-1848 2.98 µM 0.642773642664109 0.244463659636489 no 854 0.260185494044912 1278 2849525
SGTC_2821 7996764 71.43 µM 0.641228408455327 0.244949286796292 no 855 0.260687147483141 1334 2987135
SGTC_1120 ficusin 1.78878 µM 0.641099267053069 0.244989896090141 no 856 0.260729095194648 1357 6199 A DNA cross-linker.
SGTC_1102 cgs 12066b 26.1 µM 0.639582381695202 0.245467160874115 no 857 0.261222069783812 1252 6438352 A 5-HT1B full agonist.
SGTC_431 k089-0097 107 µM 0.638177109815151 0.245909753576566 no 858 0.261679197960312 1242 5499420
SGTC_2185 6113692 200 µM 0.637284147881573 0.246191215788086 no 859 0.26196988732508 1292 874150
SGTC_2080 5212524 12.4 µM 0.636986262475849 0.246285147884042 no 860 0.26206689593123 1267 260183
SGTC_828 2074-0507 139 µM 0.636771459766519 0.24635289346452 no 861 0.262136859460763 1350 X828
SGTC_1979 st071809 45.3 µM 0.63673516911449 0.246364339982773 no 862 0.262148680657614 1364 4976333
SGTC_1089 terbinafine 2.25 µM 0.635586859715366 0.246726678070307 no 863 0.262522868179793 1292 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_663 1486-0733 13.9 µM 0.635214059909563 0.246844372823702 no 864 0.262644407295759 1285 722445 YPR165W RHO1
SGTC_1096 rimcazole 32.2 µM 0.634291256995986 0.247135835513128 no 865 0.262945380627067 1230 18528119 A dopamine reuptake inhibitor.
SGTC_1929 genistein trimethyl ether 50.5 µM 0.632694901358999 0.247640470778155 no 866 0.263466450031061 1306 136420
SGTC_1982 st072467 71.9 µM 0.631452375473398 0.248033634998087 no 867 0.263872389670499 1280 3163533
SGTC_1923 st058458 19.1 µM 0.630586600752584 0.24830778309408 no 868 0.264155431130279 1372 3534982
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.630469766640378 0.248344791054377 no 869 0.264193638699974 1316 165521
SGTC_1170 0310-0127 64.8 µM 0.63031811487493 0.248392832116265 no 870 0.26424323667871 1304 774975
SGTC_1447 4239-0816 81.9 µM 0.628154418028486 0.249078798802653 no 871 0.264951393628885 1245 1341554
SGTC_2794 7785382 27.27 µM 0.627201013238436 0.249381380638888 no 872 0.265263739568201 1279 2205081
SGTC_407 eburnamonine 100 µM 0.625545731963688 0.249907180572776 no 873 0.26580647166622 1233 3195
SGTC_3206 9114350 49.47 µM 0.624963720617195 0.250092196140016 no 874 0.265997434661075 1257 17087243
SGTC_1315 1237-0019 3.69 µM 0.623486087617097 0.250562247078669 no 875 0.266482570925001 1302 825140
SGTC_103 0844-0104 51.839 µM 0.623206412294448 0.250651267454662 no 876 0.266574444234699 1333 5375804
SGTC_1747 st037496 66.6 µM 0.622827740860971 0.250771824884703 no 877 0.266698863274696 1333 723305
SGTC_551 k048-0028 34.9 µM 0.621595420494557 0.251164370528423 no 878 0.267103966515592 1324 6836383
SGTC_3010 9080089 71.4286 µM 0.619602368285856 0.25179992833575 no 879 0.267759803584205 1342 17027233
SGTC_1961 st076550 68.7 µM 0.619541309586316 0.251819412537848 no 880 0.267779908463245 1301 1579337
SGTC_3334 9142812 21.919 µM 0.619441723379916 0.251851192809229 no 881 0.267812700977391 1355 45283678
SGTC_2711 st079103 59.1 µM 0.618182257104065 0.252253300389944 no 882 0.268227602254724 1310 54693780
SGTC_2524 avocatin b 10.57 µM 0.617598876402656 0.252439669971772 no 883 0.268419892718142 1259 6710748
SGTC_2602 kawain 100 µM 0.613817898279264 0.253649316341251 no 884 0.269667834259249 1288 5369129
SGTC_2993 9054257 71.4286 µM 0.610251855378821 0.254792982114653 no 885 0.270847491992652 1323 6470217 YGL055W OLE1
SGTC_1186 1319-0216 26 µM 0.610232320974317 0.254799254420298 no 886 0.270853961118612 1380 4565136
SGTC_2697 mebhydrolin 72.4 µM 0.60829142525604 0.255422859767197 no 887 0.27149710354911 1370 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_3170 9103054 49.47 µM 0.607753793659416 0.255595740520104 no 888 0.271675389597412 1280 16432970
SGTC_2568 diosmetin 100 µM 0.607300188278574 0.255741649333847 no 889 0.271825856712194 1331 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_285 1486-1325 46 µM 0.607116764482983 0.255800662629076 no 890 0.271886712668358 1361 22310230
SGTC_2636 apigenin dimethyl ether 100 µM 0.60693615665494 0.255858776882295 no 891 0.271946640970819 1340 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2923 7992654 58.14 µM 0.606788163626624 0.255906401794329 no 892 0.27199575210587 1349 2985126
SGTC_2580 diallyl disulphide 81.36 µM 0.606326647202445 0.256054949837537 no 893 0.272148933554908 1347 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2182 6325192 200 µM 0.605523325820482 0.256313621699828 no 894 0.272415665383301 1281 736248
SGTC_851 0394-0702 453 µM 0.605522175276476 0.256313992276057 no 895 0.272416047498726 1331 762646
SGTC_1183 1254-0324 198 µM 0.604544935576565 0.256628850120748 no 896 0.272740701695103 1377 5799357
SGTC_1755 st041960 45.185 µM 0.598797678904277 0.258484631948084 no 897 0.27465390516837 1357 2257073
SGTC_2255 7941087 197.44 µM 0.598133941520355 0.258699398760139 no 898 0.274875282218537 1388 935561
SGTC_808 0711-0032 135 µM 0.596800622683416 0.259131102340959 no 899 0.275320251087197 1330 4252555
SGTC_3042 9091578 49.47 µM 0.596742236861847 0.259150015080824 no 900 0.275339744302581 1305 25236497
SGTC_3293 9120939 62.045 µM 0.595620200872416 0.259513611331548 no 901 0.275714489219074 1369 934087
SGTC_782 0083-0095 30.5 µM 0.59427453569116 0.259950021896235 no 902 0.276164253650903 1350 3591729 An indicator and reagent.
SGTC_3304 9125678 46.087 µM 0.592176418235294 0.260631213450711 no 903 0.276866229420185 1354 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2793 7325131 81.82 µM 0.591319626661541 0.260909650219294 no 904 0.277153140766566 1369 4176441
SGTC_914 3820-6779 408 µM 0.589153768410392 0.261614183881547 no 905 0.277879063544445 1328 2893481
SGTC_107 0358-0022 2.6945 µM 0.588794584028717 0.261731117559563 no 906 0.277999539720919 1403 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_625 k213-0058 121 µM 0.588305900627525 0.261890253126451 no 907 0.278163492852656 1422 3655420
SGTC_1254 0550-0035 264 µM 0.586786941933344 0.262385205634879 no 908 0.278673403910805 1411 15121435
SGTC_1204 4049-0315 18.3 µM 0.586746068836707 0.262398530743547 no 909 0.278687131204116 1474 588402
SGTC_2520 obtusaquinone 4.71 µM 0.58448669347498 0.263135652192379 no 910 0.279446457600371 1438 5967872
SGTC_1209 2323-2347 50.3 µM 0.581999109851409 0.263948448517089 no 911 0.280283640229413 1357 5412760
SGTC_1133 3473-0247 50 µM 0.581813710800869 0.264009077245443 no 912 0.280346083873954 1324 711311
SGTC_538 2922-0838 53.3 µM 0.578285879823128 0.265164090342762 no 913 0.281535562959893 1453 777039
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.577678938758083 0.26536306146972 no 914 0.281740450515211 1249 4000243
SGTC_438 sphingosine 6.67 µM 0.57733879134627 0.26547460379583 no 915 0.28185530687551 1231 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2245 6637752 200 µM 0.577300469099991 0.265487172051377 no 916 0.281868248425431 1384 681890
SGTC_2674 ligustilide 100 µM 0.573705921603195 0.266667388993212 no 917 0.283083410248828 1350 5319022 A signalling regulator.
SGTC_350 k064-0020 19.8 µM 0.573020707080787 0.266892669754202 no 918 0.283315336785485 1440 2790705
SGTC_403 arphamenine a 50 µM 0.572271758017387 0.267139014708441 no 919 0.283568939917404 1355 5487158 An arginine aminopeptidase inhibitor.
SGTC_1751 st044839 27.194 µM 0.571654681556459 0.267342070227646 no 920 0.283777971098704 1384 5291326
SGTC_827 3253-0474 693 µM 0.570510239415627 0.267718866998671 no 921 0.284165839622382 1408 5402065
SGTC_2434 5670830 169.91 µM 0.568919632892122 0.268243003255796 no 922 0.284705340561359 1379 1549830
SGTC_2976 9009005 19.48 µM 0.568187758216505 0.268484343720214 no 923 0.284953741490476 1464 2993148
SGTC_245 methotrexate 289.6 µM 0.567558813899133 0.268691829404609 no 924 0.285167290027871 1405 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_872 0588-0139 234 µM 0.564269196913655 0.269778369095354 no 925 0.286285470705704 1380 2047100
SGTC_304 1310-0298 97 µM 0.563667970607287 0.26997718788681 no 926 0.28649005960331 1335 1550234
SGTC_2156 5649887 115 µM 0.563358287070861 0.270079625361219 no 927 0.286595467638321 1467 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_478 N-arachidonylglycine 10 µM 0.5630737661496 0.270173756653352 no 928 0.28669232719945 1366 5283389
SGTC_2409 alverine citrate 63.97 µM 0.561496503013644 0.270695877981284 no 929 0.287229556787406 1517 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_185 k048-0037 25.491 µM 0.560480538706781 0.27103245917621 no 930 0.287575855202092 1407 6827589
SGTC_998 3996-0085 177 µM 0.558668395666425 0.271633326076761 no 931 0.28819402613194 1473 715391
SGTC_2649 anisomycin 9.56 µM 0.558547689581254 0.27167337311586 no 932 0.288235224495503 1362 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2218 6965428 192.983 µM 0.557252537780418 0.272103254594231 no 933 0.288677449290263 1426 675684
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.555851127552772 0.272568785551677 no 934 0.289156315263622 1454 688751
SGTC_1825 st052143 62.6 µM 0.554447197268048 0.273035549757631 no 935 0.28963641652474 1453 674173
SGTC_503 tyrphostin 8 294 µM 0.553372763980925 0.273393033665822 no 936 0.290004092455377 1404 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_182 3448-4371 550.524 µM 0.552700475939358 0.273616834197434 no 937 0.290234263702406 1466 3491403
SGTC_38 0929-0051 58.268 µM 0.552668106670972 0.273627612013675 no 938 0.290245348127407 1464 1379719
SGTC_2089 5281248 129.67 µM 0.551548747057139 0.274000448170567 no 939 0.290628779862656 1402 2737878
SGTC_958 1222-0007 33 µM 0.5515079181797 0.274014052192242 no 940 0.290642770094034 1492 7312461
SGTC_2237 6667747 47.222 µM 0.550760301951499 0.2742632139831 no 941 0.290899000440131 1417 729940 YDL015C TSC13
SGTC_1650 st011916 45.8 µM 0.547519205353599 0.27534468251042 no 942 0.292011039871707 1449 242528
SGTC_2373 9071805 200 µM 0.547322720741861 0.275410311653949 no 943 0.292078518486295 1471 10149009
SGTC_3317 9138495 8.753 µM 0.547047622746471 0.275502211910817 no 944 0.292173007449817 1407 17020139
SGTC_1805 st050013 60.3 µM 0.544288509943083 0.276424764759341 no 945 0.293121476239316 1431 4037144
SGTC_3294 9122953 26.2835 µM 0.542790469417429 0.276926292032469 no 946 0.293637037961724 1395 16459826
SGTC_1828 st055811 49 µM 0.541326633524364 0.277416797980398 no 947 0.294141233043638 1406 5877589
SGTC_1814 st052110 31.539 µM 0.540620869948004 0.277653438738981 no 948 0.294384464979286 1464 674163
SGTC_1901 st060216 58.6 µM 0.540610928266687 0.277656772863981 no 949 0.294387891909382 1411 688792
SGTC_2886 9058944 51.95 µM 0.540168607554409 0.277805133008894 no 950 0.294540379942673 1344 4949929
SGTC_1878 temozolomide 1 mM 0.540098117322132 0.277828779928798 no 951 0.294564684493095 1493 5394 DNA alkylating agent.
SGTC_3051 9093778 49.47 µM 0.539372839886081 0.278072141296805 no 952 0.29481480892206 1429 17217378
SGTC_2397 5161689 200 µM 0.533667320454672 0.279990203738838 no 953 0.296785861355488 1513 2259942
SGTC_1875 nocodazole 6 µM 0.533495166295152 0.280048177492728 no 954 0.296845428094376 1442 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1492 4158-0558 28.5 µM 0.533365375929275 0.280091888878873 no 955 0.296890340233527 1527 3967268
SGTC_156 3474-0145 5.642 µM 0.533057975248613 0.280195429857999 no 956 0.296996724337164 1424 2265471
SGTC_1534 6-azauridine 81.6 µM 0.532422481421438 0.28040954038352 no 957 0.297216708983943 1430 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1136 pergolide 1.05886 µM 0.53233911330691 0.280437634637895 no 958 0.297245573491448 1439 47811 A dopamine receptor agonist.
SGTC_2716 st080858 38.6235 µM 0.52815107946486 0.281850712642297 no 959 0.298697240248686 1417 5296050
SGTC_2959 9079155 11 µM 0.527280228323232 0.282144975504221 no 960 0.298999501161901 1439 16189457
SGTC_1471 k673-0312 37 µM 0.524969847337979 0.282926375131039 no 961 0.299802076112342 1428 24099884
SGTC_1210 3013-0140 750 nM 0.52387206024928 0.283298024219078 no 962 0.300183764469611 1568 905973
SGTC_3305 9127027 53.8275 µM 0.522798075525893 0.283661841575736 no 963 0.300557389494116 1443 41905295
SGTC_1578 josamycin 24.2 µM 0.521013603980489 0.284266834048792 no 964 0.301178647283054 1388 5282165 A P450 substrate.
SGTC_656 4090-1979 187 µM 0.519720399814852 0.284705656413922 no 965 0.301629233200529 1532 22330961
SGTC_2130 NSC 7 2.4545 µM 0.518958773733494 0.284964249841166 no 966 0.301894745289985 1520 21448
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.517343337486655 0.285513106243032 no 967 0.302458253244757 1519 688798
SGTC_2010 4012422 159 µM 0.517079174945734 0.285602905269732 no 968 0.302550445149153 1504 952393
SGTC_277 nystatin 15.5 µM 0.515411114723927 0.286170253393211 no 969 0.30313288361594 1434 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_916 4466-0038 42 nM 0.514148344533195 0.286600108167274 no 970 0.303574139738506 1493 5722064 YGL116W CDC20
SGTC_3233 9132340 49.47 µM 0.513802183925005 0.286717996836596 no 971 0.303695150445578 1420 17682950
SGTC_694 1315-0438 43.2 µM 0.509641170908629 0.288136869959587 no 972 0.305151437313295 1497 6793154
SGTC_1043 0916-0009 19.3 µM 0.508219024214996 0.288622569464679 no 973 0.305649875332647 1630 3101130
SGTC_2303 7774051 200 µM 0.508141121988516 0.288649186207101 no 974 0.305677189144611 1547 2953184
SGTC_1820 st053765 18.6 µM 0.507217128506557 0.288964973884622 no 975 0.306001239010412 1447 3690829
SGTC_3014 9081533 49.47 µM 0.507138647061461 0.288991803502353 no 976 0.306028769909864 1577 21367265
SGTC_3301 9125354 19.7965 µM 0.506744379838254 0.289126605177526 no 977 0.306167093462309 1441 41905162
SGTC_1553 gossypol 38.6 µM 0.506432288833254 0.289233331408582 no 978 0.306276606151055 1432 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2788 5282734 71.43 µM 0.504907713093911 0.289754958879265 no 979 0.306811828232571 1606 743706
SGTC_152 4469-0003 551.229 µM 0.50311261667933 0.290369709166177 no 980 0.307442548378808 1491 697280
SGTC_1993 st073995 70.8 µM 0.501750752896013 0.290836501244253 no 981 0.30792142935354 1493 3098394
SGTC_992 3909-8734 162 µM 0.500107519118029 0.291400202170898 no 982 0.30849968599012 1466 4288319
SGTC_3287 9117173 37.0625 µM 0.497227025049059 0.292389565439845 no 983 0.309514482910552 1471 2789709
SGTC_1491 4138-0063 26.5 µM 0.494991138050582 0.293158600535516 no 984 0.310303188017089 1475 23883227
SGTC_582 0987-0078 156 µM 0.493822034473286 0.293561087708743 no 985 0.310715935113641 1482 1625765
SGTC_646 4092-0839 27.3 µM 0.492041156023996 0.294174681814455 no 986 0.311345124699941 1574 877796
SGTC_1475 4092-1048 11.7 µM 0.49167419468748 0.29430119038007 no 987 0.311474841805545 1474 2881759
SGTC_357 1325-0123 420 µM 0.486864926223561 0.295961485333526 no 988 0.31317702790948 1533 1098503
SGTC_1574 spiramycin 23.7 µM 0.486685418009691 0.296023539795696 no 989 0.313240640244492 1440 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1740 st038286 13.222 µM 0.485550944658186 0.29641585564924 no 990 0.313642792112132 1536 716786
SGTC_2402 5553605 200 µM 0.483185609744899 0.297234585157345 no 991 0.314481976016927 1588 6758546
SGTC_2111 5486399 200 µM 0.482276337235324 0.297549592641521 no 992 0.314804827264641 1487 689674
SGTC_2798 7813637 45.45 µM 0.482134885197817 0.297598610843333 no 993 0.314855064728606 1567 956368
SGTC_1663 st014140 55.4 µM 0.481412961482244 0.297848840678811 no 994 0.315111513229889 1575 4207120
SGTC_1271 0832-2808 169 µM 0.481189297713377 0.297926385435823 no 995 0.315190983259841 1607 3663794
SGTC_2474 5321570 43.32 µM 0.479581509965804 0.298484079917118 no 996 0.315762498276684 1576 2841384
SGTC_227 fluconazole 33.516 µM 0.47955602837631 0.298492922556625 no 997 0.315771559685219 1471 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_429 1112-0049 25.5 µM 0.479498913328241 0.298512743094614 no 998 0.315791870546671 1463 2836170
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.479393477145832 0.298549334006428 no 999 0.315829366499522 1505 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_686 1319-0111 510 µM 0.478786654678696 0.298759967275674 no 1000 0.316045205784937 1598 4562600
SGTC_1113 artemisinin 1.17947 µM 0.476903428822587 0.299414080741962 no 1001 0.316715445128031 1586 2240 An anti-malaria and mitochondrial poison.
SGTC_2384 9036245 200 µM 0.474689581832343 0.300183860348484 no 1002 0.317504122360129 1595 6462766
SGTC_2375 9072683 200 µM 0.473824325436526 0.300484962801711 no 1003 0.31781259325286 1646 16798029
SGTC_886 0866-0150 153 µM 0.472829422507854 0.300831349735432 no 1004 0.31816744051282 1646 271463
SGTC_1457 k015-0032 57.3 µM 0.472097251482276 0.301086378519654 no 1005 0.31842868710926 1511 4302660
SGTC_2445 5742597 35.57 µM 0.47205481712608 0.301101162181764 no 1006 0.318443830919712 1474 1774255
SGTC_923 1900-2434 73.3 µM 0.471918573542255 0.301148630156126 no 1007 0.318492455058338 1474 5910570
SGTC_1220 1838-0075 193 µM 0.471557184940392 0.301274556157561 no 1008 0.318621446619907 1542 5529645
SGTC_288 1315-0019 35.1 µM 0.471157891063721 0.30141371783563 no 1009 0.318763993392718 1524 6811474
SGTC_2088 5278280 127.392 µM 0.469422902033617 0.302018730947248 no 1010 0.319383690740566 1549 791502
SGTC_3057 9095946 49.47 µM 0.469360149026257 0.30204062394952 no 1011 0.319406114111662 1546 24540043
SGTC_2859 9028643 45.46 µM 0.469348766552069 0.302044595095055 no 1012 0.319410181452722 1532 17151580
SGTC_2572 astragaloside iv 100 µM 0.469302809483667 0.302060628948329 no 1013 0.319426603680741 1538 45006101 An anti-inflammatory agent.
SGTC_2627 acetyl isogambogic acid 100 µM 0.468390365556381 0.302379048450481 no 1014 0.319752728279275 1459 6857789 A caspase activator and apoptosis inducer.
SGTC_2142 5622915 118.518 µM 0.468371795128451 0.302385530615978 no 1015 0.31975936714728 1502 5322196
SGTC_3306 9127676 59.7925 µM 0.467831626930742 0.302574108175683 no 1016 0.319952500794069 1514 41905287
SGTC_1946 st076057 65.1 µM 0.46783031356442 0.302574566747867 no 1017 0.319952970439209 1459 953009
SGTC_1374 2889-5571 141 µM 0.4669016197217 0.302898905459111 no 1018 0.320285133200648 1514 2853281
SGTC_226 1,3-diallylurea 8.28947 mM 0.465567052862114 0.303365264304924 no 1019 0.320762715380248 1539 74537 YKL182W FAS1
SGTC_341 1486-1430 230 µM 0.463745661816328 0.304002259067188 no 1020 0.321414989167061 1466 2054753 YPL210C SRP72
SGTC_3107 9121808 49.47 µM 0.463103177997766 0.30422709699773 no 1021 0.321645206085507 1538 662681
SGTC_452 diindolylmethane 8 µM 0.462985011039496 0.304268457719998 no 1022 0.321687555520288 1562 3071 Inhibits expression of several cancer promoting factors.
SGTC_2374 9071832 200 µM 0.46264943080748 0.304385930947887 no 1023 0.321807835554501 1505 17381698
SGTC_2989 9073649 71.4286 µM 0.460842435455179 0.305018834552945 no 1024 0.322455826954661 1588 21367202
SGTC_2100 5377183 190 µM 0.459460456620493 0.305503269338276 no 1025 0.3229517711528 1643 2844202
SGTC_326 k292-0812 17.5 µM 0.459056839972808 0.305644816252531 no 1026 0.323096674615184 1604 3579357
SGTC_1138 3761-0006 1.03 µM 0.456597824536456 0.306507811151452 no 1027 0.323980071571967 1564 12061087
SGTC_1783 st039459 87.517 µM 0.455882130630083 0.306759186949742 no 1028 0.324237369987654 1689 729761
SGTC_464 bw-b 70c 158 µM 0.455467059584346 0.306905015535136 no 1029 0.324386630247548 1611 5353454
SGTC_2742 clothiapine 36.27 µM 0.454898571041377 0.307104794495496 no 1030 0.32459110549286 1613 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1619 st003326 88.7 µM 0.454831146789314 0.307128492611557 no 1031 0.32461536030952 1622 2849032
SGTC_198 3454-2873 16.191 µM 0.453558086896722 0.307576095799231 no 1032 0.325073463142032 1555 710957
SGTC_1433 4060-0023 7.6 µM 0.452509725721491 0.307944911000079 no 1033 0.325450908197108 1583 3840627
SGTC_887 0885-0007 9.62 µM 0.451559670933189 0.30827930950855 no 1034 0.325793114372504 1626 5719458
SGTC_490 phenamil 164 µM 0.451430158751428 0.308324907297767 no 1035 0.325839775553714 1616 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_443 clozapine 122 µM 0.450023395892941 0.308820381432034 no 1036 0.326346785482106 1589 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2447 5741742 33.78 µM 0.44642259597443 0.310090199046905 no 1037 0.327646006838519 1632 1776504
SGTC_3195 9113082 49.47 µM 0.446299164597331 0.310133767259739 no 1038 0.327690579816439 1642 17018038
SGTC_2915 7971052 15.16 µM 0.444955581320059 0.310608191130058 no 1039 0.328175927224697 1479 5741558
SGTC_1192 1488-0095 21.4 µM 0.444557356221385 0.310748866362954 no 1040 0.328319835299054 1568 915875
SGTC_2170 morpholine 200 µM 0.444517483675915 0.310762953085896 no 1041 0.3283342455916 1629 121171 Reacts with secondary amines.
SGTC_1273 0849-0096 14.1 µM 0.444220284933885 0.310867960295984 no 1042 0.32844166390585 1541 5286025
SGTC_1227 3909-8010 46.6 µM 0.442354999813545 0.311527360256181 no 1043 0.329116168565079 1574 15982272
SGTC_885 0865-0106 16.8 µM 0.441143453641758 0.311955980141206 no 1044 0.329554573450226 1502 2793380
SGTC_580 1123-0028 41 µM 0.441036714729689 0.311993754371633 no 1045 0.329593208775239 1588 1677248 YPR107C YTH1
SGTC_1128 3448-9350 235 µM 0.440505321260352 0.312181840600617 no 1046 0.329785579555292 1561 619386
SGTC_3110 9122132 49.47 µM 0.439895513540849 0.312397741816068 no 1047 0.330006392721924 1637 918317
SGTC_1010 4112-3296 15.2 µM 0.439435578754019 0.312560623437966 no 1048 0.33017297565386 1712 704384
SGTC_3075 9116269 49.47 µM 0.438992117899544 0.312717705647398 no 1049 0.330333623807231 1579 17015205 YNL244C SUI1
SGTC_1948 st076329 66.6 µM 0.436386496350381 0.313641352441158 no 1050 0.331278167359725 1510 24208413
SGTC_120 rhodamine 6G 52.259 µM 0.435727258950257 0.313875226051759 no 1051 0.331517312910223 1552 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1011 4112-3381 17.4 µM 0.435667140051016 0.313896557787887 no 1052 0.331539125115696 1613 2877139
SGTC_683 panaxydol 45 µM 0.434777170730063 0.314212414584493 no 1053 0.331862088601267 1661 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2278 7948257 134.34 µM 0.434573367544131 0.314284765027268 no 1054 0.331936064912531 1710 1247028
SGTC_2479 5617353 43.85 µM 0.434117159577031 0.314446745414531 no 1055 0.332101682647182 1643 2731746
SGTC_1732 st034308 51.822 µM 0.433907743501489 0.314521112279493 no 1056 0.332177718207235 1543 830119
SGTC_1871 st057448 67.3 µM 0.43047966873142 0.315739542458772 no 1057 0.333423376551675 1667 691747
SGTC_2188 6126565 140.678 µM 0.429275200638182 0.316168119629973 no 1058 0.333861481042374 1625 874518
SGTC_2707 st078556 66.6 µM 0.428756436495672 0.316352783893667 no 1059 0.334050242389812 1699 17250899
SGTC_1691 st019933 84.6 µM 0.428557966979427 0.316423445124283 no 1060 0.334122470079419 1655 6176082
SGTC_1775 st081588 35.1725 µM 0.427414509290879 0.31683068158505 no 1061 0.334538720613075 1570 1426443 YGL099W LSG1
SGTC_684 1140-0066 328 µM 0.42663401399977 0.317108778433688 no 1062 0.334822959573065 1580 6813534
SGTC_744 1594-0068 283 µM 0.425313505744405 0.317579521544963 no 1063 0.335304074689455 1581 668392
SGTC_783 0848-0141 92.7 µM 0.424054400829513 0.318028650091328 no 1064 0.335763069794246 1552 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3178 9107506 49.47 µM 0.423093254102041 0.318371675829398 no 1065 0.336113612002058 1613 8897194
SGTC_2912 7964298 10.93 µM 0.42288826672086 0.318444854384861 no 1066 0.336188391914276 1581 2975850
SGTC_286 k060-0067 22.9 µM 0.421758413505931 0.318848328356063 no 1067 0.336600681477674 1586 5985051
SGTC_2437 5741531 144.16 µM 0.420828916718875 0.319180415513953 no 1068 0.336940007245021 1717 2262990
SGTC_473 2-arachidonoylglycerol 10 µM 0.419899660740031 0.31951256173821 no 1069 0.337279377806729 1570 5282280 An endocannabinoid.
SGTC_838 0109-0203 71.4 µM 0.418815546219057 0.319900242493013 no 1070 0.337675471130553 1595 759422
SGTC_745 0469-0705 296 µM 0.417883374794243 0.320233745578243 no 1071 0.338016194199001 1720 3486736
SGTC_2090 5301565 104.445 µM 0.413999269310911 0.321624923708079 no 1072 0.339437320978644 1608 2056344
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.413100260452496 0.321947281300479 no 1073 0.339766579302945 1633 1241132 A phosphatase inhibitor.
SGTC_263 alizarin 107.927 µM 0.412086899664437 0.322310802750688 no 1074 0.340137865170719 1642 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_3259 9138485 49.47 µM 0.411563193581394 0.322498737730775 no 1075 0.340329806958904 1705 17646153
SGTC_1298 1079-1278 263 µM 0.410807472369587 0.322770012649136 no 1076 0.340606856765911 1616 2840950
SGTC_2549 cedrol 20.94 µM 0.408612911617063 0.323558310108658 no 1077 0.341411876886669 1675 6708665 A sedative which affects the nervous system.
SGTC_1212 0520-0165 585 µM 0.408145659092942 0.323726252054025 no 1078 0.34158337023614 1807 5403258
SGTC_2093 5331342 194.4 µM 0.407429726580139 0.323983645286389 no 1079 0.341846198795596 1700 33839
SGTC_1621 st003705 32.4 µM 0.406219600175104 0.324418903265286 no 1080 0.342290626929162 1720 24207032
SGTC_2720 fluspirilene 36.88 µM 0.406204819678581 0.324424220995432 no 1081 0.342296056530953 1672 3396 An atypical antipsychotic.
SGTC_1094 duloxetine 25.4 µM 0.404082642925051 0.325188109358566 no 1082 0.343075974073856 1625 60834 A selective serotonin reuptake inhibitor.
SGTC_1081 sertraline 6 µM 0.403769007317555 0.325301066534103 no 1083 0.343191294579056 1716 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_97 0535-0701 19.132 µM 0.40248705927215 0.325762932290676 no 1084 0.343662805099383 1545 2832013 YGL099W LSG1
SGTC_1561 5-methoxyflavone 52.9 µM 0.401542108014016 0.326103554746565 no 1085 0.344010521400402 1651 94525
SGTC_1417 3966-0327 90.4 µM 0.401300099351602 0.32619081390974 no 1086 0.344099595226636 1650 651118
SGTC_826 1683-5028 118 µM 0.399290939198809 0.326915608081778 no 1087 0.344839421322861 1630 722377
SGTC_2297 7971671 152.32 µM 0.399073958930564 0.326993921739556 no 1088 0.344919354785451 1721 909016
SGTC_1007 4101-0031 70 µM 0.398668949268406 0.32714012033633 no 1089 0.345068575000262 1730 1146276
SGTC_1789 tunicamycin 25 nM 0.398668359732011 0.32714033316391 no 1090 0.34506879222437 1611 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2368 9071271 200 µM 0.396141314843795 0.328053133284066 no 1091 0.346000390615543 1576 27209959
SGTC_3286 9117135 37.221 µM 0.396125469426632 0.328058860094675 no 1092 0.346006234998111 1565 3438150
SGTC_2490 carminic acid 95.39 µM 0.395908507515691 0.328137277985326 no 1093 0.34608626235602 1628 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_177 1327-0068 8.361 µM 0.395316056019342 0.328351449984969 no 1094 0.346304825710131 1599 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2252 omeprazole 400 µM 0.394835090673618 0.328525361093484 no 1095 0.346482297971998 1704 4594 A proton pump inhibitor.
SGTC_383 2324-0395 7.37 µM 0.39483220494121 0.328526404650723 no 1096 0.346483362885309 1697 3146421
SGTC_3242 9133940 49.47 µM 0.394349602584334 0.328700945250416 no 1097 0.346661473271428 1672 17248444
SGTC_2019 4016004 108 µM 0.392586370659349 0.329338962809361 no 1098 0.347312503811807 1589 45595336
SGTC_1004 4084-0029 199 µM 0.392347883489114 0.329425296538372 no 1099 0.347400594053003 1759 716894 YLR208W SEC13
SGTC_1779 st039427 55 µM 0.389776333933565 0.330356789165321 no 1100 0.348350972606947 1804 1124498
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.389108143826036 0.330599000178899 no 1101 0.348598074691111 1668 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2819 7996655 46.38 µM 0.389040834481734 0.330623402956165 no 1102 0.348622969792683 1717 6456960
SGTC_2751 anetholtrithion 17.25 µM 0.387043376274277 0.331347902072616 no 1103 0.349362047999175 1747 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2916 7875993 68.79 µM 0.386858298631419 0.331415063696992 no 1104 0.349430557430437 1798 1299250
SGTC_3080 9117754 49.47 µM 0.386216193294751 0.331648115157683 no 1105 0.349668280945501 1774 9550191
SGTC_2860 9025725 38.96 µM 0.385634399245512 0.331859332987938 no 1106 0.349883726623919 1584 40546248
SGTC_1677 st019204 53.9 µM 0.383458644521971 0.332649704673167 no 1107 0.350689863998276 1584 3945625
SGTC_1372 2752-0194 270 µM 0.382349802016736 0.333052792989338 no 1108 0.351100959504657 1600 823334
SGTC_1242 0402-0103 60.1 µM 0.382040430499929 0.333165290699318 no 1109 0.35121568792628 1615 432868
SGTC_2741 miltefosine 3.04 µM 0.381126974156908 0.333497541194197 no 1110 0.351554516385712 1660 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2487 5918373 44.05 µM 0.380215655229977 0.333829144450415 no 1111 0.351892669580809 1729 2876279
SGTC_1511 0906-3109 28.5 µM 0.379758790149191 0.333995433638607 no 1112 0.352062237649926 1648 2882180
SGTC_3033 9090887 49.47 µM 0.378979255372606 0.334279242995449 no 1113 0.352351634323197 1592 19325384
SGTC_773 4358-1457 44.6 µM 0.377901722773453 0.334671702003274 no 1114 0.352751801298962 1801 1186886
SGTC_1343 1487-0095 224 µM 0.377346504240645 0.334873994306923 no 1115 0.352958058359859 1769 4560101 YGL055W OLE1
SGTC_2460 5552655 174.22 µM 0.376723469574979 0.335101052287639 no 1116 0.353189559760226 1611 5401989
SGTC_739 1486-1183 203 µM 0.37574650545657 0.33545721721373 no 1117 0.35355268034727 1793 4346692
SGTC_527 4476-4215 268 µM 0.375013176418351 0.335724659023753 no 1118 0.353825333621099 1679 4418754
SGTC_2640 pentamidine 10.38 µM 0.374364195871932 0.335961408741845 no 1119 0.354066688502547 1811 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2845 9003024 42.97 µM 0.373517087470361 0.336270533931677 no 1120 0.35438181505399 1752 2990173
SGTC_1231 0242-0792 125 µM 0.373184134409049 0.33639206485746 no 1121 0.35450570177979 1626 3707635
SGTC_2298 7976326 193.81 µM 0.372797460613627 0.336533225800644 no 1122 0.354649596486055 1703 2235818
SGTC_617 3770-0098 35 µM 0.371964867312298 0.336837254400075 no 1123 0.354959503676044 1679 5962639
SGTC_3106 9121286 49.47 µM 0.371374231349194 0.337052994873864 no 1124 0.355179407917891 1742 15943471
SGTC_1064 honokiol 6.76 µM 0.369831425290547 0.337616785460321 no 1125 0.355754049382458 1681 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_640 3381-0960 37.1 µM 0.369730194245818 0.337653791277141 no 1126 0.355791765895818 1750 1745025
SGTC_980 1473-0395 201 µM 0.368357466687075 0.338155757638227 no 1127 0.356303353931284 1637 768876
SGTC_492 tmb-8 126 µM 0.366367371170569 0.338883988398107 no 1128 0.357045481879637 1758 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_3260 9137109 49.47 µM 0.36625998725961 0.338923300286455 no 1129 0.357085541905531 1769 17478346
SGTC_571 k831-0106 44.2 µM 0.364778975070661 0.339465658848516 no 1130 0.357638200359344 1783 4783639
SGTC_17 0960-0276 49.807 µM 0.364369999117694 0.339615487792279 no 1131 0.357790867582726 1693 6821114
SGTC_1257 0669-0121 16 µM 0.364261677091113 0.339655175973645 no 1132 0.357831307080281 1785 4307855
SGTC_1488 4013-0813 75.9 µM 0.363651713844661 0.339878694006989 no 1133 0.358059052384751 1672 2910057
SGTC_3145 9085516 49.47 µM 0.363585551823215 0.339902942140755 no 1134 0.358083758698189 1620 25236195
SGTC_2018 5133068 143 µM 0.363388974689064 0.339974990833639 no 1135 0.358157168309006 1665 785362
SGTC_2516 gossypol 71.55 µM 0.363381307390125 0.33997780114092 no 1136 0.358160031685385 1813 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1860 st056228 74.6 µM 0.362595063925383 0.340266031392456 no 1137 0.358453699054428 1641 688679
SGTC_1611 st001856 99.4 µM 0.362465139660324 0.340313669528936 no 1138 0.358502234731297 1642 647478
SGTC_2717 st081029 62.2815 µM 0.362189363720077 0.340414794204094 no 1139 0.35860526364565 1786 5292846
SGTC_1347 1493-0251 600 nM 0.361814298643212 0.340552345771183 no 1140 0.358745403144663 1796 3986378
SGTC_2724 maprotiline 69.64 µM 0.360329352366082 0.34109714383608 no 1141 0.359300425742019 1741 4011 A tricyclic antidepressant.
SGTC_2013 4024628 200 µM 0.356902359065887 0.342355704954952 no 1142 0.360582451771734 1722 5230760
SGTC_430 0958-0115 16.4 µM 0.35646970065661 0.342514723376408 no 1143 0.360744419567123 1682 6833180
SGTC_1842 st055362 61.2 µM 0.356082788521099 0.342656951949863 no 1144 0.36088928318122 1751 676032
SGTC_477 mead ethanolamide 10 µM 0.355266342989806 0.34295714982079 no 1145 0.361195033691762 1684 16061185
SGTC_793 0488-0545 106 µM 0.352936373218805 0.343814398353126 no 1146 0.362068070707633 1650 292548
SGTC_3002 9075603 71.4286 µM 0.35250542599937 0.343973041768615 no 1147 0.36222962496827 1695 20105405
SGTC_168 3970-0862 530.542 µM 0.351822820707912 0.344224383587559 no 1148 0.362485571472107 1719 3135186
SGTC_1926 methyl fluorone black 53.6 µM 0.351655396193274 0.344286041415107 no 1149 0.36254835758121 1696 72721 Reacts with homocysteine.
SGTC_803 4488-1585 147 µM 0.350805416029036 0.344599129464091 no 1150 0.362867166860791 1778 747204
SGTC_189 3970-0742 2.116 µM 0.347892830797234 0.345672779358034 no 1151 0.363960334785664 1820 2891807
SGTC_535 2293-4129 48.2 µM 0.346256246403228 0.346276610063443 no 1152 0.364575073709382 1820 396118 YIL048W NEO1
SGTC_660 4031-1742 102 µM 0.345882169878395 0.346414683493366 no 1153 0.36471563447652 1700 6738706
SGTC_1453 4237-0541 195 µM 0.344348198140083 0.346981093070709 no 1154 0.365292220585435 1848 739892
SGTC_1797 st048695 56.8 µM 0.344332441989348 0.346986912708867 no 1155 0.365298144557321 1801 592262 YIL048W NEO1
SGTC_1662 st014054 52 µM 0.34299389117576 0.347481446927596 no 1156 0.365801527924026 1727 2838777
SGTC_570 0987-0065 62.6 µM 0.34226461037072 0.347750992680967 no 1157 0.366075882926001 1815 3104428
SGTC_2555 cholic acid 100 µM 0.341936001021524 0.347872473468739 no 1158 0.366199527957359 1754 6708657 Influences liver metabolism.
SGTC_2476 5806916 10.51 µM 0.341665743533974 0.347972394359189 no 1159 0.366301227490054 1754 2870194
SGTC_1735 st034310 56.75 µM 0.340603720159881 0.348365152921612 no 1160 0.366700964231359 1807 871153
SGTC_2349 9023730 187.07 µM 0.340209924317407 0.348510828258737 no 1161 0.366849222478674 1818 4126287
SGTC_1675 st018485 24.5 µM 0.33953759673965 0.348759591368734 no 1162 0.367102389656452 1702 3323024
SGTC_32 0928-0142 34.1 µM 0.339486500856662 0.348778499650696 no 1163 0.367121632345084 1803 2244242
SGTC_1986 st071812 45 µM 0.338402158575843 0.349179854323036 no 1164 0.367530073839484 1721 11838594
SGTC_1166 k206-0078 225 µM 0.33814487861846 0.349275107814707 no 1165 0.36762700604268 1678 5404595
SGTC_798 1287-0182 476 µM 0.337481617351033 0.349520712700301 no 1166 0.367876933707776 1848 1649755
SGTC_24 0417-1663 219 µM 0.336312006362067 0.349953971776423 no 1167 0.36831779847132 1721 4329390
SGTC_1498 4478-3555 97.6 µM 0.335910352554994 0.350102801529205 no 1168 0.368469235008323 1835 3437919
SGTC_2874 9043904 71.43 µM 0.335121571305686 0.350395145396407 no 1169 0.368766690615797 1713 4463428
SGTC_1889 st059080 5.18 µM 0.334869048750656 0.350488755891127 no 1170 0.368861935481307 1852 176925 Isolated from Daphnopsis sellowiana.
SGTC_1977 st070720 65.3 µM 0.334624715173828 0.350579339363288 no 1171 0.368954099346572 1711 682188
SGTC_2656 pseudo-anisatin 100 µM 0.334544329526215 0.3506091431467 no 1172 0.368984422868519 1749 6708809 A neurotoxin.
SGTC_934 2950-0684 338 µM 0.334531130181951 0.350614037023591 no 1173 0.368989402076667 1847 1121253
SGTC_2304 7443016 91.4 µM 0.331874183931348 0.351599647913279 no 1174 0.369992132434518 1707 939854
SGTC_2362 9071156 126 µM 0.331168624403422 0.351861547695414 no 1175 0.370258559191378 1785 653133
SGTC_3252 9135871 49.47 µM 0.329064193771902 0.352643117821572 no 1176 0.371053583830114 1792 17682838
SGTC_1161 k007-0610 110 µM 0.328949922747353 0.352685575089017 no 1177 0.371096769627599 1783 5843850
SGTC_3315 9136395 68.55 µM 0.328138071119205 0.35298727042759 no 1178 0.3714036347968 1887 16876844
SGTC_1798 st045719 60.953 µM 0.327572398065383 0.35319753705069 no 1179 0.371617497277595 1820 3980186
SGTC_852 0418-0143 439 µM 0.326462817095099 0.353610110113522 no 1180 0.372037108609219 1845 5369229
SGTC_2215 7188065 200 µM 0.325219662843821 0.35407255376493 no 1181 0.37250741403803 1836 940217
SGTC_1167 k781-0610 148 µM 0.324333004741976 0.354402515237906 no 1182 0.372842967420686 1739 4525169
SGTC_2948 9070189 9.45 µM 0.323908711899966 0.354560450514525 no 1183 0.373003574065668 1875 6473636 YDL196W YDL196W
SGTC_524 r073-0010 27.8 µM 0.323360507164831 0.354764546761438 no 1184 0.373211117491061 1706 2772106
SGTC_1787 fluconazole 80 µM 0.322603611602877 0.355046406974908 no 1185 0.37349772910018 1739 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2943 9068529 45.32 µM 0.322127403534188 0.355223782691854 no 1186 0.373678089410825 1748 3270634
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.321021061799659 0.355635988651139 no 1187 0.374097214972234 1751 5379071
SGTC_760 0568-0725 82.9 µM 0.320545898238864 0.355813079178052 no 1188 0.374277271261672 1876 3916171
SGTC_734 2023-0417 80 µM 0.318252075443148 0.35666840989638 no 1189 0.375146867022881 1808 3935732
SGTC_161 4065-0411 162.148 µM 0.317309205352826 0.357020200852623 no 1190 0.375504496573847 1778 1906281 YLR208W SEC13
SGTC_147 4466-0538 29.23 µM 0.316204413884126 0.357432560435267 no 1191 0.375923678854574 1773 6742687 YHR072W ERG7
SGTC_2171 5739187 198.077 µM 0.316133235890927 0.357459133088942 no 1192 0.375950690383984 1686 2262761
SGTC_2262 9014885 67.46 µM 0.316128806392356 0.357460786762389 no 1193 0.375952371366483 1870 6457424
SGTC_3291 9121177 71.43 µM 0.314902624199041 0.35791866260052 no 1194 0.376417794539139 1727 17015612
SGTC_246 cycloheximide 667 µM 0.314751308147387 0.357975180596314 no 1195 0.376475242192875 1724 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1122 capsaicin 818.572 nM 0.312584423606297 0.358784873687593 no 1196 0.377298206841068 1824 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_283 0987-0079 11.7 µM 0.31006811689205 0.359725931040268 no 1197 0.378254578613891 1873 411556
SGTC_1456 k015-0012 13 µM 0.309948075828377 0.359770845739466 no 1198 0.378300221275369 1928 2989616
SGTC_1765 st044815 90.4 µM 0.309651902185828 0.359881670684962 no 1199 0.378412841279831 1699 645695
SGTC_2070 5230947 200 µM 0.30923667891412 0.360037062536888 no 1200 0.378570747285551 1861 2835538
SGTC_3063 1327-0034 4 µM 0.308834787307296 0.360187487218739 no 1201 0.378723602679371 1839 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1882 5615643 20 µM 0.307143969093761 0.360820583287828 no 1202 0.37936689579146 1812 2253075
SGTC_2764 methyldopa 94.69 µM 0.302979673118884 0.362381452086128 no 1203 0.380952676238612 1892 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1323 1348-1351 11.2 µM 0.302948640909453 0.362393092263654 no 1204 0.380964500973394 1751 6989654
SGTC_347 4534-1311 26.2 µM 0.300527752439546 0.363301558509038 no 1205 0.381887315403297 1745 2862016
SGTC_2992 9074591 71.4286 µM 0.299547668533641 0.363669565379159 no 1206 0.382261103220519 1823 17741321
SGTC_2621 lithochol-11-enic acid 100 µM 0.298951857980124 0.36389334485887 no 1207 0.382488389188672 1930 6708711
SGTC_1973 st070275 50.2 µM 0.298815045727746 0.363944736499 no 1208 0.38254058516304 1878 17118334
SGTC_110 0850-0284 111.64 µM 0.298301885507264 0.364137519872663 no 1209 0.382736382669552 1812 3906265
SGTC_2372 9071633 200 µM 0.29776109945578 0.364340718894023 no 1210 0.382942753315131 1900 21321366
SGTC_82 0054-0107 293.755 µM 0.297747090683563 0.364345983162489 no 1211 0.382948099677702 1908 3104697
SGTC_1409 3909-8004 61.9 µM 0.296741743636862 0.364723842968588 no 1212 0.383331842420567 1803 2119279
SGTC_2995 9067767 71.4286 µM 0.295839319441285 0.365063131176239 no 1213 0.383676396855422 1802 11673567
SGTC_2966 9084041 48.03 µM 0.29501111405323 0.365374608028406 no 1214 0.383992694786157 1604 17741380
SGTC_1943 st076331 65.2 µM 0.294971246702488 0.365389603842297 no 1215 0.384007922381734 1946 24208415
SGTC_3166 9102297 49.47 µM 0.294761330093468 0.365468565841254 no 1216 0.384088104357861 1742 25237072
SGTC_1501 4491-0275 38.4 µM 0.294440221119021 0.365589364868893 no 1217 0.384210768148599 1897 5104718
SGTC_1027 k015-0025 8.67 µM 0.294381090674823 0.365611610796545 no 1218 0.384233357273052 1721 3598955
SGTC_3336 9143619 71.43 µM 0.293793666695447 0.3658326347127 no 1219 0.384457787440655 1895 45595730
SGTC_2533 agelasine 13.65 µM 0.292757881178926 0.366222467436483 no 1220 0.384853612148838 1956 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1445 4239-0156 97.7 µM 0.290829622677166 0.366948562774398 no 1221 0.385590814247128 1919 4008346
SGTC_2804 7954240 19.48 µM 0.289742563481375 0.367358110417891 no 1222 0.386006595695359 1884 828705
SGTC_1289 0976-0073 69.1 µM 0.288825720462781 0.367703646772993 no 1223 0.386357374221519 1863 3391136
SGTC_2839 9003951 25.97 µM 0.288768998944383 0.367725027286966 no 1224 0.386379078581499 1913 2990634
SGTC_222 nsc-310342 10.666 µM 0.28825156403151 0.367920087253004 no 1225 0.386577090279608 1905 432556
SGTC_984 1492-0255 2.91 µM 0.28778222195894 0.368097046891078 no 1226 0.386756723383943 1820 1585198
SGTC_3257 9139206 32.98 µM 0.286157286172009 0.368709924891368 no 1227 0.387378828530406 1897 4910041
SGTC_1039 k821-0043 94 µM 0.284472345175127 0.369345787911713 no 1228 0.388024212158093 1909 15992768
SGTC_805 3852-0218 479 µM 0.284268634592163 0.369422688474425 no 1229 0.388102260503922 1741 6615355
SGTC_2864 9034755 47.6 µM 0.283958403763163 0.369539810370566 no 1230 0.388221129004779 1957 4930451
SGTC_2086 5274770 176.623 µM 0.282029234024988 0.37026840396885 no 1231 0.388960547141554 1800 689278
SGTC_835 0312-0010 67.2 µM 0.280910868107135 0.370690993004058 no 1232 0.389389382309408 1801 1626196
SGTC_696 1560-0013 611 µM 0.280863309845367 0.370708966971313 no 1233 0.389407621419803 1865 1650269
SGTC_2600 tangeritin 87.95 µM 0.280049665553478 0.371016515914396 no 1234 0.389719700557865 1740 68077 A bioactive flavone.
SGTC_1143 3454-2408 5.08 µM 0.277571496921627 0.371953744439407 no 1235 0.390670657392589 1833 X1143
SGTC_969 1313-0238 134 µM 0.276790658118956 0.372249210560442 no 1236 0.390970427387923 1797 5212874
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.275567266264511 0.372712288096067 no 1237 0.39144022711358 1841 88881 An O-methylated flavonoid and antioxidant.
SGTC_2346 9031566 143.75 µM 0.273714339244188 0.37341400715766 no 1238 0.39215207866193 1916 4771086
SGTC_2496 diffractaic acid 79.83 µM 0.2728776146871 0.373731019580139 no 1239 0.392473647304174 1945 94870 An apoptosis inducer which activates caspases.
SGTC_1965 Pectolinarigenin 58.4 µM 0.271647558426278 0.374197209890266 no 1240 0.39294651381864 1805 5320438 An anti-inflammatory.
SGTC_747 3448-8087 38.7 µM 0.270082201886077 0.374790744771407 no 1241 0.393548507156627 1794 5168703
SGTC_2308 7584454 197.62 µM 0.269743619291657 0.374919163918195 no 1242 0.393678750299915 1919 893577
SGTC_1402 3909-7673 35.9 µM 0.268921930536539 0.375230875414064 no 1243 0.393994880150522 1800 5328014
SGTC_1125 tnp00248 1.32998 µM 0.267175269423892 0.375893750034476 no 1244 0.394667108192873 1991 24207736
SGTC_1415 3966-0071 78.1 µM 0.267103003903852 0.375921183397854 no 1245 0.394694927406555 1869 2893185
SGTC_2270 7924575 90.91 µM 0.267049883158902 0.375941349441065 no 1246 0.394715377022095 1977 1262135
SGTC_458 nppb 133 µM 0.263696929161132 0.377214903129 no 1247 0.396006730991561 1993 4549 A chloride channel blocker.
SGTC_2212 7123476 200 µM 0.262885791249713 0.377523199246497 no 1248 0.396319304091564 1910 1085715
SGTC_1182 1222-0449 220 µM 0.26159120305113 0.378015406078247 no 1249 0.396818313433685 1865 658318
SGTC_1470 k295-0292 231 µM 0.257108111873063 0.379721418562767 no 1250 0.398547657815931 1936 5045612
SGTC_127 0180-0333 59.125 µM 0.256602309256123 0.379914046358266 no 1251 0.398742896077192 1959 771601
SGTC_1773 st048542 73.5835 µM 0.256332940861689 0.380016643676721 no 1252 0.398846881797123 1776 3237138
SGTC_2782 7736369 71.43 µM 0.25536409297726 0.380385729241629 no 1253 0.399220950626404 1817 2950836 YOL077C BRX1
SGTC_673 1082-0474 110 µM 0.25535555101973 0.380388983811365 no 1254 0.399224249058878 1797 3098046
SGTC_2030 5175110 200 µM 0.253797350354585 0.3809828150031 no 1255 0.399826060275411 1903 2831986
SGTC_2638 epoxomicin 18 µM 0.252771331549906 0.381373984582821 no 1256 0.400222461265744 1964 9915668 A protesome inhibitor.
SGTC_1334 1486-0610 236 µM 0.251376450443307 0.381905977231521 no 1257 0.400761536547247 1899 3742339
SGTC_2504 purpurogallin 52.29 µM 0.250902448407626 0.382086807344072 no 1258 0.400944765698633 1824 5281571 An antioxidant.
SGTC_846 0335-0850 148 µM 0.249594915591655 0.382585759769357 no 1259 0.40145031546959 1916 6819598
SGTC_2147 5545932 89.7195 µM 0.247561904375364 0.383361940563844 no 1260 0.40223669459422 1874 797404
SGTC_1356 1502-0781 85.8 µM 0.247086061706921 0.383543679697652 no 1261 0.402420810255264 1854 567702
SGTC_2458 5808907 16.39 µM 0.2469543849392 0.383593975684175 no 1262 0.402471763179941 2000 2731747
SGTC_1463 k081-0032 34.1 µM 0.246693989141779 0.383693443677202 no 1263 0.402572529396448 1893 977755
SGTC_1484 3473-2379 286 µM 0.245716612640972 0.384066857806105 no 1264 0.402950805683329 1986 671917
SGTC_1644 st010134 20.9 µM 0.244782335845272 0.384423906005311 no 1265 0.403312485931724 1988 3818134
SGTC_1361 1608-0041 5.61 µM 0.242138727999545 0.385434731739763 no 1266 0.404336335152038 1857 X1361
SGTC_1999 st074831 12.5 µM 0.241868474253301 0.385538111569788 no 1267 0.404441039423167 1851 17112523
SGTC_3023 9089636 49.47 µM 0.241538329636188 0.38566441241516 no 1268 0.404568956470664 2029 17249241
SGTC_3064 1327-0027 10 µM 0.241446621838335 0.385699498502651 no 1269 0.404604491166645 1892 16000455 YPR107C YTH1
SGTC_586 0957-0265 8.15 µM 0.241259174247709 0.385771216170113 no 1270 0.40467712531283 2007 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1876 myriocin 605 nM 0.238850019322185 0.386693308456413 no 1271 0.405610941340079 2004 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1382 3002-2117 298 µM 0.23877932242624 0.386720377039955 no 1272 0.405638352409093 2014 1497314
SGTC_3267 9137951 49.47 µM 0.238778026251334 0.386720873327408 no 1273 0.405638854974938 1883 16643986
SGTC_3174 9107204 49.47 µM 0.238430556949443 0.386853921198475 no 1274 0.405773584840682 1963 3938802
SGTC_2800 7887935 81.82 µM 0.237942258863484 0.38704091564215 no 1275 0.405962939379811 1900 2961002
SGTC_2635 hydroquinidine 100 µM 0.23730338756873 0.387285611898398 no 1276 0.406210717127361 1866 442912 An experimental heart treatment.
SGTC_2531 methyl deoxycholate 70.07 µM 0.235180374747131 0.388099075456361 no 1277 0.407034368770495 1858 16667744 Haematoxylin.
SGTC_2493 resveratrol 26.09 µM 0.234413626126808 0.388392987386492 no 1278 0.407331940597618 1868 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1148 3909-7663 27.7 µM 0.234025990997114 0.388541600955575 no 1279 0.407482400483747 2000 4084526
SGTC_435 c-PAF 6.7 µM 0.233909441183265 0.388586287619918 no 1280 0.407527641756693 2028 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2944 9067346 25.62 µM 0.231871037735884 0.389368075047943 no 1281 0.408319090032682 1915 6473075
SGTC_2317 5986382 200 µM 0.231463558955772 0.389524408924436 no 1282 0.408477346266057 1963 877883
SGTC_2694 st077685 81.9 µM 0.231453438680023 0.389528291911177 no 1283 0.408481276959504 1840 2838096
SGTC_1363 1636-0063 10.4 µM 0.231358509629784 0.389564715195062 no 1284 0.408518147647679 1896 6072185
SGTC_2261 9010538 184.68 µM 0.230739438779538 0.389802269983781 no 1285 0.408758616209946 1832 6457250
SGTC_1508 1080-0625 72.9 µM 0.228089913851457 0.390819430892183 no 1286 0.409788170514265 1975 767111
SGTC_1655 st012546 55.1 µM 0.225463364171343 0.391828509404498 no 1287 0.410809411405899 1939 720985 YLR208W SEC13
SGTC_932 2857-0803 154 µM 0.224536258532808 0.392184862825015 no 1288 0.411170028419759 2007 674898
SGTC_3024 9090631 49.47 µM 0.224065850333264 0.392365709157085 no 1289 0.411353032198953 2048 25236383
SGTC_2275 7947463 200 µM 0.224060012594438 0.392367953595831 no 1290 0.411355303386636 2024 1225414
SGTC_558 k064-0027 21.3 µM 0.223462455809713 0.392597715517771 no 1291 0.411587800131462 1956 5088526
SGTC_3046 9092212 49.47 µM 0.223182352564353 0.392705428734707 no 1292 0.411696793090506 1928 25236637
SGTC_3218 9131285 49.47 µM 0.221603849471751 0.393312592783533 no 1293 0.41231114277799 2010 17156417
SGTC_972 1319-0219 195 µM 0.221342009623097 0.393413333431591 no 1294 0.412413071053738 1878 23903702
SGTC_3011 9081274 71.4286 µM 0.219728969329911 0.394034094075003 no 1295 0.413041120858762 1893 6625322
SGTC_2594 a-mangostin 100 µM 0.218953498721011 0.394332621282684 no 1296 0.413343135723401 2014 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2880 9042983 58.44 µM 0.218879689671992 0.394361038246787 no 1297 0.413371884078984 1915 6464714
SGTC_2077 5212015 200 µM 0.2159034110602 0.395507391763471 no 1298 0.414531519083357 2004 780900
SGTC_233 rapamycin 362 pM 0.215082591794023 0.395823700859329 no 1299 0.414851463015942 2040 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1190 1486-1332 13 µM 0.214710228681304 0.395967216521707 no 1300 0.414996623615893 1992 4150046
SGTC_2005 4024620 188 µM 0.214695643891194 0.395972838057946 no 1301 0.41500230953055 1945 236743
SGTC_608 k048-0125 159 µM 0.21451114802497 0.396043951692576 no 1302 0.415074237213774 2023 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.214381567557682 0.396093900343567 no 1303 0.415124757244372 2003 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_3016 9080866 49.47 µM 0.211669763234178 0.397139594466816 no 1304 0.416182339511201 1935 17066299
SGTC_76 0433-0009 400.328 µM 0.211446903471445 0.397225564032124 no 1305 0.416269280161691 1881 2841569
SGTC_295 k015-0027 31 µM 0.209304799413687 0.398052148331934 no 1306 0.417105152682324 1969 3887424
SGTC_3125 9127534 49.47 µM 0.208756262556618 0.398263888732734 no 1307 0.417319258217168 2081 1639235
SGTC_112 phenothiazine 287.218 µM 0.208657792239503 0.398301902377602 no 1308 0.417357695861803 2059 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.208461405797825 0.398377718607474 no 1309 0.417434357181244 1897 279621
SGTC_718 1130-0073 349 µM 0.207904147415305 0.398592872613704 no 1310 0.417651905381204 1993 6740020
SGTC_576 1073-0113 22.7 µM 0.207361887049101 0.398802265571585 no 1311 0.417863622700783 2056 5439563
SGTC_2378 9074213 121.43 µM 0.205913175703501 0.399361825817724 no 1312 0.418429366634262 2017 657714
SGTC_316 k060-0003 58.6 µM 0.205813814782925 0.399400211255478 no 1313 0.418468174791408 2014 6152314
SGTC_1472 k841-0093 193 µM 0.204510939203241 0.399903632289756 no 1314 0.418977122197635 2033 X1472
SGTC_3312 9133330 71.43 µM 0.203898121424182 0.40014047793012 no 1315 0.419216556564632 2027 17617324
SGTC_1603 st002045 67.8 µM 0.202958780036905 0.400503591733052 no 1316 0.419583625197874 2060 5887985
SGTC_2150 5556613 200 µM 0.201265869924225 0.401158223647839 no 1317 0.420245344164119 1967 743190
SGTC_861 0443-0273 110 µM 0.200009114118313 0.401644378558193 no 1318 0.420736726554767 1987 6149169
SGTC_2866 9034245 58.44 µM 0.199713820172592 0.401758630188501 no 1319 0.420852202292698 2087 6462273
SGTC_1988 st071872 53.4 µM 0.196674621052568 0.40293500733281 no 1320 0.422041085821761 2089 16414116
SGTC_2411 st077133 39.94 µM 0.196020190909693 0.403188431792456 no 1321 0.422297181250568 2081 1403142 YNL221C POP1
SGTC_2853 9015042 58.44 µM 0.195179097978238 0.403514200093626 no 1322 0.422626370885604 1961 6457456
SGTC_3272 9137413 49.47 µM 0.194902782957849 0.403621235797128 no 1323 0.422734527744713 2061 17614870
SGTC_2461 5755302 26.15 µM 0.192944770741722 0.404379914200485 no 1324 0.423501110884801 2077 2788904
SGTC_947 3447-0010 211 µM 0.1909114293743 0.405168161408491 no 1325 0.424297492761779 2041 748350
SGTC_454 lyso-paf C-16 6.67 µM 0.190458329593514 0.405343863083287 no 1326 0.424474996818742 1889 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1288 0973-0013 65.5 µM 0.190396819847259 0.405367716619781 no 1327 0.424499094744629 1988 4315430
SGTC_2110 5483698 200 µM 0.190235455600754 0.405430295494204 no 1328 0.424562314419241 1958 2848765 YHR062C RPP1
SGTC_842 0271-0008 11.1 µM 0.188832529160197 0.405974467899254 no 1329 0.4251120379438 2025 1221709
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.188672920636155 0.40603638898852 no 1330 0.42517458828943 2029 16725076
SGTC_575 k072-0246 11.9 µM 0.188378937847003 0.406150447535226 no 1331 0.425289804640626 1986 6796779
SGTC_1954 st077032 68.9 µM 0.187160851322505 0.406623121805175 no 1332 0.42576725926333 1863 698907
SGTC_337 1315-0038 354 µM 0.186839570225328 0.406747816533223 no 1333 0.425893210315333 1968 1626437
SGTC_2908 7930301 100 µM 0.186507631753802 0.406876657502488 no 1334 0.426023347293082 2022 2223178
SGTC_1573 oleylamine 1.06 µM 0.1857946377804 0.407153438135825 no 1335 0.426302904875787 1945 5356789 An amine of the fatty acid oleic acid.
SGTC_3221 9128209 49.47 µM 0.185169447470668 0.40739617199505 no 1336 0.42654806602739 1970 16460723
SGTC_2332 7982454 138.89 µM 0.184943635968346 0.407483853402021 no 1337 0.426636622379258 2057 2981748
SGTC_31 0508-1974 57.237 µM 0.183919473262937 0.407881588465102 no 1338 0.427038313971372 2046 6810525
SGTC_2894 9048625 32.47 µM 0.182373971812434 0.408481965817162 no 1339 0.427644625367888 2092 4092861
SGTC_237 nikkomycin 200 µM 0.181586853709478 0.408787818425519 no 1340 0.427953483271098 2091 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_221 trifluoperazine 10.304 µM 0.180961171630445 0.40903098104308 no 1341 0.428199026667322 2065 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2121 5257820 149.641 µM 0.179249076553008 0.409696541650914 no 1342 0.428871065087521 2117 791256
SGTC_123 0083-0120 66.675 µM 0.178906767697102 0.409829642235082 no 1343 0.429005454335932 1890 16001701
SGTC_1630 st005209 31.3 µM 0.178722768271634 0.409901191366213 no 1344 0.429077695262838 2139 3367314
SGTC_1744 st037937 38.9 µM 0.176332509160072 0.410830927815272 no 1345 0.430016361770219 2041 1016152
SGTC_166 k072-0058 166.424 µM 0.176244904781454 0.410865012746573 no 1346 0.430050771989532 2141 5846229
SGTC_184 1494-0393 24.714 µM 0.173725728135592 0.411845455784698 no 1347 0.431040508423395 1955 3090647
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.173429889769153 0.411960629911789 no 1348 0.43115676621668 2083 91467 include heat shock
SGTC_2502 avocadyne acetate 18.59 µM 0.172276866869996 0.412409590590459 no 1349 0.431609935001011 2120 3952079
SGTC_2200 6600604 21.907 µM 0.171541654131602 0.41269592546371 no 1350 0.431898940277398 2049 2904777
SGTC_597 k018-0003 82.8 µM 0.171092416675955 0.412870907701943 no 1351 0.432075549285914 2070 6786234
SGTC_3261 9137475 49.47 µM 0.170792455671424 0.412987754992556 no 1352 0.432193480707937 2124 17027690
SGTC_711 k292-0785 179 µM 0.169242873209243 0.413591504388595 no 1353 0.432802804107735 2060 4146315
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.168782794984223 0.413770799792958 no 1354 0.432983745887108 2072 616764
SGTC_2467 5474540 200 µM 0.168443277199968 0.413903123559257 no 1355 0.43311728208862 2093 5413519
SGTC_439 amiodarone 34.4 µM 0.16687634893767 0.414513945110192 no 1356 0.433733671498028 2050 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_710 3448-4187 58 µM 0.16280649454264 0.416101422385869 no 1357 0.435335397296303 2027 3946412
SGTC_1998 st075797 76.8 µM 0.159844523884662 0.417257624061692 no 1358 0.436501774992811 2148 24208315
SGTC_1928 4'-methoxychalcone 40.3 µM 0.159741411793084 0.417297886693931 no 1359 0.436542388927811 2158 641818
SGTC_2330 7979373 200 µM 0.159697664211836 0.417314969266575 no 1360 0.436559620488511 1933 1863007
SGTC_2890 9046729 58.44 µM 0.15739937234256 0.418212625895429 no 1361 0.437465054044511 1973 903329
SGTC_1521 st012942 49.4 µM 0.156901448145897 0.418407159244706 no 1362 0.437661259270126 2146 24207259
SGTC_1193 1488-0126 41.5 µM 0.156401319645556 0.418602573882155 no 1363 0.437858348524629 2075 1384710
SGTC_1106 tegaserod maleate 11.7 µM 0.155692770576481 0.418879458830636 no 1364 0.438137597961304 2032 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_373 0844-0104 25.9 µM 0.155336466222827 0.419018709706647 no 1365 0.438278034310427 2151 5375804
SGTC_951 1171-0579 82.7 µM 0.154347909578402 0.419405110509108 no 1366 0.438667711750378 2102 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2817 7995342 71.43 µM 0.152879776054719 0.419979108648765 no 1367 0.439246542392411 1998 18879975
SGTC_381 3461-2219 42.7 µM 0.152539551457472 0.420112151061734 no 1368 0.4393806989316 2111 2883159
SGTC_3099 9120367 49.47 µM 0.15139225222452 0.420560861493311 no 1369 0.439833150425591 2096 24824940
SGTC_893 0958-0369 48.9 µM 0.151226379727109 0.420625743028958 no 1370 0.439898570791575 2159 6819948
SGTC_459 nigericin 15.3 µM 0.150913751970745 0.42074803419459 no 1371 0.44002187611532 2059 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2466 5983409 37.09 µM 0.150713169971482 0.420826500247137 no 1372 0.440100991887645 2025 2879657
SGTC_81 0411-0046 9.971 µM 0.149838903865418 0.421168542756677 no 1373 0.440445857492684 2075 12925265
SGTC_203 k066-0004 30.888 µM 0.149513143295082 0.421296006554985 no 1374 0.440574369542286 2158 6795412
SGTC_1368 1852-0141 284 µM 0.147824583484581 0.42195683918813 no 1375 0.441240603833053 2039 2838987
SGTC_224 benfluorex 43.875 µM 0.147672620210733 0.422016322151292 no 1376 0.441300570299499 2147 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_921 1561-0023 372 µM 0.145889000414676 0.422714616827013 no 1377 0.442004507540292 2169 24050882
SGTC_2906 7926292 26.41 µM 0.145266370453959 0.422958436398652 no 1378 0.442250282765242 2032 2966319
SGTC_2712 st079126 47.7 µM 0.144811436398267 0.423136605544668 no 1379 0.4424298762345 2088 3152970
SGTC_667 1498-1044 59 µM 0.144350554120438 0.423317120266811 no 1380 0.442611829937173 2048 6739982
SGTC_2965 9082772 38.63 µM 0.144203810802158 0.423374598908537 no 1381 0.442669765907426 2163 16459634
SGTC_1276 0871-0068 94.2 µM 0.143929650792196 0.42348199041517 no 1382 0.442778010754772 2119 3414906
SGTC_2327 6189656 200 µM 0.143107633844511 0.423804017582325 no 1383 0.443102588032353 2123 5349088
SGTC_2099 5377090 177.372 µM 0.142797918610733 0.42392536250028 no 1384 0.443224890471854 2031 2243829
SGTC_2221 6807166 181.081 µM 0.141381711432787 0.424480317298462 no 1385 0.443784200651755 2139 674925
SGTC_2836 9010338 19.48 µM 0.140699910142236 0.424747541348708 no 1386 0.444053508042903 1951 2994051
SGTC_400 oxethazaine 37.5 µM 0.140628076417163 0.424775697754142 no 1387 0.444081883436909 2046 4621 A local anesthetic.
SGTC_3117 9124945 49.47 µM 0.140626175575449 0.424776442825407 no 1388 0.444082634301662 1958 17592065
SGTC_404 fumagillin 50 µM 0.140262550138808 0.424918977710005 no 1389 0.444226276212105 2048 12015870 A methionine aminopeptidase binder.
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.139889761979948 0.425065114413736 no 1390 0.444373545251793 2168 1273210
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.139084459640917 0.425380836145926 no 1391 0.444691704136868 2129 23847180
SGTC_1327 1436-0082 2.18 µM 0.138578977096473 0.425579036889497 no 1392 0.444891428421768 2042 15992205
SGTC_2556 citropten 84.59 µM 0.138575421327351 0.425580431180541 no 1393 0.444892833412963 2132 2775 A potential DNA crosslinker.
SGTC_195 4234-0266 16.654 µM 0.138200186220143 0.425727573899586 no 1394 0.445041103963782 2041 2303354
SGTC_1845 st056753 3.01 µM 0.136748914103244 0.426296765288857 no 1395 0.445614632404896 2091 5375839
SGTC_1900 st060200 72.8 µM 0.132974543267135 0.427777796076418 no 1396 0.447106756607396 2035 688945
SGTC_1151 3909-8316 15.3 µM 0.131848535283071 0.42821983009521 no 1397 0.447552048010524 2074 800431
SGTC_202 3594-0513 34.79 µM 0.131582882893532 0.428324129715113 no 1398 0.447657112631405 2180 708429
SGTC_2151 5563267 85.4165 µM 0.13149743040602 0.428357680871275 no 1399 0.447690909582021 2044 5310824
SGTC_3300 9124615 50.48 µM 0.131367184940946 0.428408820061999 no 1400 0.447742423143531 2141 24824903
SGTC_2910 7948405 25.97 µM 0.131185685405287 0.42848008550278 no 1401 0.447814209742129 2154 2971328
SGTC_1048 3161-0300 24.5 µM 0.130710962713499 0.428666495469352 no 1402 0.448001979881636 2143 2165101
SGTC_1077 5-fluorocytosine 377 nM 0.130250986861694 0.428847129956695 no 1403 0.448183928222934 2112 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_292 k038-0015 474 µM 0.129501543387986 0.429141471527356 no 1404 0.448480401894683 2140 46368540
SGTC_3191 9110352 49.47 µM 0.128942879810273 0.429360910537582 no 1405 0.448701423338406 2153 17122424
SGTC_2379 9035213 200 µM 0.128596745501073 0.429496880546378 no 1406 0.448838370819982 2215 646551
SGTC_3207 9114163 49.47 µM 0.128439308257394 0.429558728508529 no 1407 0.44890066262959 2195 849233
SGTC_1087 pterostilbene 9.05 µM 0.125815601369748 0.430589684131036 no 1408 0.449938945902538 2165 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3012 9080433 71.4286 µM 0.125245392385763 0.430813804077294 no 1409 0.450164641106243 2183 17688859
SGTC_2814 7977482 42.97 µM 0.125226031657304 0.43082141417958 no 1410 0.4501723045862 2146 6456762
SGTC_2106 5357045 167.29 µM 0.12493466604177 0.430935944073 no 1411 0.450287636918377 2153 668842
SGTC_2961 9083290 32.55 µM 0.124070276562614 0.431275752124265 no 1412 0.450629816077422 2193 17741490
SGTC_2439 5492030 7.2 µM 0.122908499885217 0.431732548870662 no 1413 0.451089777364644 2202 5722370
SGTC_1413 3910-0535 34.4 µM 0.122496646237858 0.431894506768997 no 1414 0.45125285095288 2170 2876951
SGTC_3018 9082602 49.47 µM 0.121388010199215 0.432330525145937 no 1415 0.451691856564332 2091 17332089
SGTC_1895 st058434 18.3 µM 0.120997552348508 0.432484108993033 no 1416 0.451846486947143 2206 5393175
SGTC_2505 galangin 7.89 µM 0.120232338033635 0.43278513022412 no 1417 0.45214955076551 2027 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2892 9047358 58.44 µM 0.120080883589474 0.432844714245777 no 1418 0.452209537745674 2085 6466771
SGTC_2565 isoliquiritigenin 100 µM 0.119757709164675 0.432971860101238 no 1419 0.452337541978972 1927 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_819 1013-0258 27.7 µM 0.119384741632456 0.433118604582028 no 1420 0.452485274624787 2105 5753198
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.118392848671759 0.433508910769099 no 1421 0.45287819593074 2180 16486 A toxic proline analog.
SGTC_3136 9095672 49.47 µM 0.117879978218131 0.433710748843171 no 1422 0.453081378846491 2215 17217380
SGTC_1673 st016611 27.3 µM 0.11691020002585 0.434092448300685 no 1423 0.453465607567258 2154 5226799
SGTC_456 gingerol 170 µM 0.11653995048624 0.434238192750151 no 1424 0.453612312938646 2144 442793 A herb.
SGTC_1224 0823-0416 294 µM 0.11607282333454 0.434422084702562 no 1425 0.453797413520691 2181 3598164
SGTC_3111 9122088 49.47 µM 0.116027703873039 0.434439847440555 no 1426 0.453815292779355 2212 16876704
SGTC_87 0100-0052 35.5 µM 0.115363509471174 0.434701344384223 no 1427 0.454078500515714 2182 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1061 3448-9325 110 µM 0.113757460927644 0.435333772258701 no 1428 0.454715030438764 2220 723482
SGTC_256 clotrimazole 625 nM 0.112499746890212 0.4358291489826 no 1429 0.45521358521097 2202 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2545 solidagenone 89.61 µM 0.112013028636078 0.436020880115137 no 1430 0.455406538113506 2229 6708572 An anti ulcer agent
SGTC_2867 9039098 71.43 µM 0.11157793693026 0.436192286921261 no 1431 0.455579033272257 2220 6463460
SGTC_2796 7949634 45.45 µM 0.11095173835964 0.43643900237129 no 1432 0.455827308779256 2158 2971588
SGTC_2057 5236571 38.335 µM 0.11014739768451 0.436755940149519 no 1433 0.456146239448507 2178 54684039 YBR257W POP4
SGTC_2416 tofa 880 nM 0.109417813977819 0.437043456242959 no 1434 0.45643555253364 1939 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_380 3970-0968 6 µM 0.108201644834653 0.437522800936516 no 1435 0.45691787011431 2159 2891601
SGTC_10 0279-0212 42.575 µM 0.107693519511072 0.437723102238247 no 1436 0.457119405148461 2209 39851 YBR002C RER2
SGTC_3185 9108267 49.47 µM 0.107610513879849 0.43775582429806 no 1437 0.457152328278114 2091 4910486
SGTC_2210 7115885 190.385 µM 0.106958190811521 0.438012994596101 no 1438 0.457411074159192 2189 2927039
SGTC_963 1269-2853 151 µM 0.105729468698818 0.438497474105962 no 1439 0.457898499374941 2127 3668223
SGTC_2061 5245884 80.95 µM 0.105062620762954 0.438760447832541 no 1440 0.458163059706801 2189 573863
SGTC_42 0133-0086 60.653 µM 0.104383406700661 0.439028325975443 no 1441 0.45843254513846 2205 162923 Model of phenazepam hydroxylation.
SGTC_300 r073-0011 5.04 µM 0.104060627369107 0.439155638095468 no 1442 0.458560617989888 2243 2735780
SGTC_483 fpl-64176 144 µM 0.103244984117316 0.439477375906329 no 1443 0.458884269242496 2217 3423
SGTC_2491 paeonol 100 µM 0.102281588815091 0.439857447327499 no 1444 0.459266584328063 2109 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2328 6201408 200 µM 0.101482425875694 0.440172769120327 no 1445 0.459583753825396 2130 2890418
SGTC_559 1550-0661 158 µM 0.0993034224496303 0.441032720013865 no 1446 0.460448680564438 2146 5830875
SGTC_791 1348-1292 225 µM 0.0991465320298939 0.441094648117288 no 1447 0.460510963424336 2203 5437054
SGTC_71 0417-1750 47.813 µM 0.0979913397956436 0.441550672179726 no 1448 0.460969585056748 2238 6811472
SGTC_471 1-acyl-paf 4 µM 0.0975675223875421 0.441717997940072 no 1449 0.46113785740242 2185 16759367
SGTC_465 cgp-37157 41 µM 0.0964507920352241 0.442158939793562 no 1450 0.461581276955151 2228 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3330 9141424 71.43 µM 0.0941723725410517 0.443058797235842 no 1451 0.46248611537021 2229 27261020
SGTC_577 r071-0003 38.6 µM 0.0938570311515796 0.443183363965392 no 1452 0.462611363637852 2222 4568517 YMR134W ERG29
SGTC_1945 st075991 56.6 µM 0.0937159277910312 0.443239104690932 no 1453 0.462667408707908 2065 1084980
SGTC_618 k072-0232 33.2 µM 0.0923259640033828 0.443788248496242 no 1454 0.463219530087427 2184 5872756 YGL099W LSG1
SGTC_2918 7977171 22.06 µM 0.0918294682570855 0.443984429155017 no 1455 0.463416765345524 2237 2236483
SGTC_1819 st053448 58.6 µM 0.0913570110003996 0.444171124218009 no 1456 0.463604459552067 2161 2857616
SGTC_2928 9011484 9.79 µM 0.0912472103689625 0.444214514544767 no 1457 0.463648081469106 2162 2994751
SGTC_2936 9038235 15.59 µM 0.0906839889213642 0.44443709537389 no 1458 0.463871846597839 2241 4749415
SGTC_1407 3909-7909 12.3 µM 0.0900421403169053 0.444690770416975 no 1459 0.464126863841565 2197 4411780
SGTC_75 0159-0059 199.013 µM 0.089251117925685 0.445003433923888 no 1460 0.46444117060315 2233 5377270
SGTC_2525 harmine 47.85 µM 0.0888122389543466 0.445176922214905 no 1461 0.464615565425436 2202 5280953 A monoamine oxidase inhibitor
SGTC_1834 st055981 52.8 µM 0.0884888146457137 0.445304778148928 no 1462 0.464744087042283 2237 471719 YDL150W RPC53
SGTC_216 k038-0035 28.382 µM 0.0877636874596144 0.445591455718733 no 1463 0.46503224978389 2242 4444231 YPR107C YTH1
SGTC_2693 st077581 40.7 µM 0.087634952466894 0.445642353816437 no 1464 0.46508341049376 2263 25238761
SGTC_2250 alverine citrate 130 µM 0.0872613867392283 0.44579005598385 no 1465 0.465231872909956 2210 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_269 exalamide 29 µM 0.0869404411747429 0.445916958954076 no 1466 0.465359426897365 2131 3316 A derivative of salicylamide.
SGTC_2131 toluylene red 5.2905 µM 0.0859843742580128 0.446295023857474 no 1467 0.465739419377042 2178 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1312 1218-2183 165 µM 0.0858189575267439 0.446360440833667 no 1468 0.465805168073915 2259 6744073
SGTC_2007 4011539 71.82 µM 0.0857523189774559 0.446386794640887 no 1469 0.465831655366873 2206 45595301
SGTC_2385 9074692 200 µM 0.0855261048128076 0.446476258205358 no 1470 0.465921571430528 2103 17046906
SGTC_1851 st056236 18.9 µM 0.0853335457016269 0.446552413958515 no 1471 0.465998111586318 2264 5393171
SGTC_6 0844-0013 19.835 µM 0.0848249958341258 0.446753551269499 no 1472 0.466200260676116 2261 1584900
SGTC_54 0159-0055 9 µM 0.0844627268327354 0.446896841176319 no 1473 0.466344268294463 2269 3319099
SGTC_2877 9040724 71.43 µM 0.0841026788929935 0.447039259445772 no 1474 0.46648739737196 2257 6463895
SGTC_1426 4048-4480 71.7 µM 0.0840415376100073 0.447063444781073 no 1475 0.466511703164732 2251 14224343
SGTC_523 1934-0222 13.7 µM 0.0839637991079854 0.447094195675163 no 1476 0.466542607111367 2218 1361595
SGTC_1944 st076371 56.9 µM 0.0837774210819046 0.44716792222596 no 1477 0.466616700131691 2092 24208455
SGTC_3122 9126309 49.47 µM 0.0832332145121942 0.447383207363462 no 1478 0.46683305149845 2278 17591206
SGTC_2642 cholecalciferol 100 µM 0.0831867305807321 0.447401596871645 no 1479 0.466851531815267 2254 9821465 A vitamin D precursor, similar to steriods.
SGTC_1762 st045503 25.4615 µM 0.0829422501371651 0.447498317640561 no 1480 0.466948729503721 2175 4645554
SGTC_397 arbidol 50 µM 0.0827644831189444 0.447568647364291 no 1481 0.467019405283149 2247 131410 A RNA synthesis inhibitor.
SGTC_2688 kanamycin b 96.69 µM 0.0819431345717682 0.44789361774324 no 1482 0.467345966662562 2172 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_37 0566-0070 1.56 µM 0.0817423385144457 0.447973068967506 no 1483 0.467425804863718 2237 1626686
SGTC_3278 9139605 49.47 µM 0.0813774373864198 0.448117458823409 no 1484 0.467570895973495 2219 7958859
SGTC_2236 dapsone 200 µM 0.0813032389346179 0.448146819683234 no 1485 0.467600399111361 2282 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3349 9149703 23.001 µM 0.0789503782113554 0.449078010034452 no 1486 0.468536046122716 2266 4910494
SGTC_585 0kpi-0023 191 µM 0.0787409781157972 0.44916089786199 no 1487 0.468619325412754 2255 64601
SGTC_313 3474-0040 5.03 µM 0.077744771648857 0.449555261291036 no 1488 0.469015539616749 2259 1043375 YIL048W NEO1
SGTC_818 4072-2707 53.5 µM 0.0776935319833704 0.449575546639963 no 1489 0.469035919642311 2258 882871
SGTC_2492 derrusnin 100 µM 0.0766161599925434 0.450002099505718 no 1490 0.46946445146324 2210 1715307 Part of coumarin class of compounds.
SGTC_995 3931-2021 34.6 µM 0.0756975373371721 0.450365846019835 no 1491 0.469829867647025 2184 730143
SGTC_1960 st011366 51.8 µM 0.0753094483474164 0.450519529952965 no 1492 0.469984252069254 2271 3972846
SGTC_1741 st038134 10.228 µM 0.0745369127631612 0.450825477486146 no 1493 0.470291585352541 2240 1272587
SGTC_2024 5144227 134 µM 0.074393638384399 0.450882221705077 no 1494 0.470348585306025 2240 3475211
SGTC_1053 3366-3204 134 µM 0.0743102113337474 0.450915263684647 no 1495 0.470381776014358 2182 3632071 YPR165W RHO1
SGTC_950 1165-0508 94.1 µM 0.0742542643316966 0.450937422152213 no 1496 0.470404034145621 2196 6148369
SGTC_1042 0350-0096 82 µM 0.0724998312984816 0.451632363196914 no 1497 0.471102069860827 2195 3122515
SGTC_2770 toltrazuril 17.5 µM 0.070356627916501 0.452481499376536 no 1498 0.47195490578426 2284 68591 Kills coccidiodes.
SGTC_1267 0828-0272 9.49 µM 0.070336990182067 0.452489280848693 no 1499 0.471962720746027 2260 745334
SGTC_807 1315-0151 48 µM 0.0691479941060682 0.452960455638839 no 1500 0.472435909325436 2297 4011080
SGTC_3193 9111931 49.47 µM 0.0689667111363576 0.453032300202256 no 1501 0.472508058524595 2238 17087244
SGTC_2149 5554786 194.827 µM 0.0683173611030492 0.453289657823657 no 1502 0.472766502127251 2221 745063 YPR165W RHO1
SGTC_427 1354-0053 47.3 µM 0.0671575819039131 0.453749363148539 no 1503 0.473228126792906 2219 6813657
SGTC_1301 naphtanilide LB 4.81 µM 0.0662003142353411 0.454128845056722 no 1504 0.473609173300765 2285 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2932 9016711 44.54 µM 0.0655945969216128 0.454368986345487 no 1505 0.473850295441343 2293 7117328
SGTC_723 4182-0001 115 µM 0.0654575971966955 0.454423303256498 no 1506 0.47390483321462 2195 744821 YLR208W SEC13
SGTC_810 3825-7150 143 µM 0.0650656059955242 0.454578722515515 no 1507 0.474060882410485 2301 22330411 YGL099W LSG1
SGTC_1704 st028805 70.8 µM 0.0645974758493227 0.454764338955363 no 1508 0.474247247247305 2182 2876101
SGTC_1857 st056007 79.3 µM 0.0642538797295449 0.454900583186958 no 1509 0.474384038084738 2290 619834
SGTC_1341 1486-1360 280 µM 0.0625921735346042 0.455559564759365 no 1510 0.475045630906494 2286 3976547
SGTC_549 1661-1316 519 µM 0.0608550404515615 0.456248589029549 no 1511 0.475737327782794 2293 2857282
SGTC_1493 4348-0038 111 µM 0.0606621103640606 0.456325121842642 no 1512 0.475814153815124 2298 800424
SGTC_569 4130-2812 160 µM 0.0600632307727864 0.456562699761451 no 1513 0.476052637329919 2335 743552
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.0594504575225889 0.456805805422434 no 1514 0.47629666240255 2178 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2403 6032726 181.2 µM 0.0589452491460051 0.457006249011607 no 1515 0.476497858538767 2241 2881040
SGTC_3213 9129884 49.47 µM 0.0586479029606096 0.45712422750228 no 1516 0.476616277636972 2233 17190742
SGTC_614 0462-0418 107 µM 0.0559784309299287 0.458183565933418 no 1517 0.477679494918813 2272 5188303
SGTC_1686 st019653 115.5 µM 0.0545731276406671 0.458741358519663 no 1518 0.478239273940425 2319 97252
SGTC_3295 9122362 53.5725 µM 0.0544105714655909 0.458805885534346 no 1519 0.478304028260631 2234 4730473
SGTC_2361 9034121 116 µM 0.0540436000052523 0.458951559613752 no 1520 0.478450213598348 2245 6496917
SGTC_2755 lomerizine 42.69 µM 0.0526522832329052 0.459503910749808 no 1521 0.479004479357214 2287 3949 A calcium channel blocker.
SGTC_3230 9131665 49.47 µM 0.0522717474243396 0.459654996681736 no 1522 0.479156082410189 2290 15943720
SGTC_2523 spermine 47.74 µM 0.0520626984687438 0.4597379988583 no 1523 0.479239367473178 2314 1103 A DNA binding polyamine.
SGTC_544 k015-0020 52.4 µM 0.0519095225858424 0.4597988179356 no 1524 0.479300393290571 2247 3008304
SGTC_839 0122-0028 230 µM 0.0501049520938342 0.460515400076016 no 1525 0.480019376748365 2253 759448
SGTC_284 0988-0104 32.6 µM 0.0499252639487774 0.460586760022728 no 1526 0.48009097234201 2292 4666532
SGTC_2619 obliquin 87.91 µM 0.0488235085659579 0.461024330217955 no 1527 0.480529973693108 2291 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2820 7989630 71.43 µM 0.0484651603900171 0.461166661009478 no 1528 0.4806727648895 2318 2984098
SGTC_1068 loratadine 26.9 µM 0.0465756715908666 0.461917220887221 no 1529 0.481425711120017 2238 3957 A H1 histamine antagonist.
SGTC_1197 1601-0112 267 µM 0.045256426877049 0.462441343812298 no 1530 0.481951459071371 2327 7350313
SGTC_3274 9138298 49.47 µM 0.0443838149146099 0.46278805983983 no 1531 0.482299231381037 2329 17015756
SGTC_1908 st060353 56.5 µM 0.0443348722085438 0.462807507147646 no 1532 0.482318737494767 2333 4227716
SGTC_141 0443-0274 32.331 µM 0.0439591319806559 0.462956809897849 no 1533 0.482468490155306 2318 1627241
SGTC_504 lovastatin 124 µM 0.0437369193712906 0.463045109937206 no 1534 0.48255705497975 2265 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_962 1254-0300 21.5 µM 0.0411845227949702 0.464059478532058 no 1535 0.483574396112316 2311 7340576
SGTC_1163 k060-0048 49.9 µM 0.0395930334146205 0.464692083908819 no 1536 0.484208790807729 2334 6809982
SGTC_764 1951-2361 146 µM 0.0384543212597528 0.465144768526234 no 1537 0.4846627254388 2312 5438930
SGTC_2421 5690543 90.72 µM 0.0373425582650189 0.46558678327938 no 1538 0.485105936276028 2278 3397993
SGTC_3235 9132602 49.47 µM 0.0371713720693043 0.465654847276288 no 1539 0.485174182305272 2283 4912240
SGTC_2393 9031399 185.94 µM 0.0370010363316281 0.465722574126495 no 1540 0.485242089717281 2311 1526623 YDL150W RPC53
SGTC_157 1348-1695 65.819 µM 0.0369023258878207 0.465761822642098 no 1541 0.485281442610897 2337 5380510
SGTC_1009 4106-0057 9.87 µM 0.0353724037959902 0.466370181279518 no 1542 0.485891394758504 2357 2928005
SGTC_1338 1486-1223 76 µM 0.0349598064679186 0.466534260106862 no 1543 0.486055895529486 2300 3444526
SGTC_2063 5246145 200 µM 0.0347455457771034 0.466619468049293 no 1544 0.486141321278444 2321 711240
SGTC_335 4077-0256 27.6 µM 0.0334552597420504 0.467132625732249 no 1545 0.486655771697889 2330 3121989
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.0316267794452392 0.467859921197891 no 1546 0.487384843579797 2353 756377
SGTC_2940 9060638 45.86 µM 0.0316070773230731 0.467867758493418 no 1547 0.487392699661773 2303 4027022
SGTC_1240 0356-0016 42.1 µM 0.03057858873804 0.468276897582829 no 1548 0.48780280893777 2321 4305613
SGTC_370 0180-0345 38.7 µM 0.0305290486019535 0.468296605803241 no 1549 0.487822563369742 2305 3989527
SGTC_3139 9095020 49.47 µM 0.029580439258104 0.468673999634856 no 1550 0.488200832848754 2359 25236292
SGTC_1410 3909-8106 77.9 µM 0.0290627981077617 0.468879949387353 no 1551 0.48840725303269 2346 1039210
SGTC_1629 st005085 44.9 µM 0.0286641600149473 0.469038558022169 no 1552 0.48856622038976 2324 24207091
SGTC_1594 piperine 70.1 µM 0.0284198443010592 0.469135767875715 no 1553 0.48866364856474 2365 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1884 5633444 25 µM 0.0261826308636177 0.470026009086977 no 1554 0.489555834848357 2331 5724239
SGTC_2174 5790901 200 µM 0.0260567090541442 0.470076120909415 no 1555 0.489606053248796 2331 786020
SGTC_855 0428-0020 25 µM 0.0253641947421903 0.470351722239327 no 1556 0.489882235185109 2319 6812414
SGTC_2718 lomofungin 53.02 µM 0.0241995059355883 0.470815267775613 no 1557 0.490346736111101 2338 5351222 A RNA synthesis inhibitor.
SGTC_244 nsc-207895 1.295 µM 0.0233606278709668 0.471149165342835 no 1558 0.490681305417935 2355 42640
SGTC_2313 7726885 200 µM 0.0231749222393801 0.471223084268878 no 1559 0.490755371194052 2349 726423
SGTC_635 k038-0028 24.7 µM 0.0229955704765154 0.471294475019683 no 1560 0.49082690313198 2339 4035102
SGTC_2802 7925815 54.55 µM 0.022725563248652 0.471401952806869 no 1561 0.490934592287711 2345 1262923
SGTC_2238 6671620 73.2395 µM 0.0199097702602182 0.472522916569904 no 1562 0.492057675575099 2373 729941
SGTC_895 0964-0006 13.7 µM 0.0198686614043979 0.472539283589034 no 1563 0.492074072392329 2366 6738897
SGTC_1329 1447-1697 50.6 µM 0.018690200861686 0.473008493736996 no 1564 0.492544122735263 2313 2840515
SGTC_297 0986-0032 24 µM 0.0184042365515805 0.473122357574902 no 1565 0.492658186368268 2370 2847425
SGTC_3219 9131112 49.47 µM 0.0161717811120532 0.474011340282138 no 1566 0.493548673965021 2381 17612988 YMR079W SEC14
SGTC_1772 st048439 82.2 µM 0.0153058973520988 0.474356177624997 no 1567 0.49389406881428 2358 2927068 YDL195W SEC31
SGTC_1581 himbacine 57.9 µM 0.0150782467974841 0.474446842431397 no 1568 0.493984877765562 2370 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2 0422-0095 29 µM 0.0148935973208651 0.474520382469182 no 1569 0.494058533977493 2309 6790840
SGTC_354 2783-3500 4.88 µM 0.0148168475409504 0.474550949731049 no 1570 0.494089149331456 2370 6740761
SGTC_2857 9024691 58.44 µM 0.0147872140002165 0.474562751970459 no 1571 0.494100970108735 2364 16478292
SGTC_3332 9141069 11.198 µM 0.0141046361714744 0.474834610453657 no 1572 0.494373250847098 2380 17332883
SGTC_2157 5649910 96.377 µM 0.0126696744955942 0.47540616796166 no 1573 0.494945666385967 2374 2858091
SGTC_480 am 92016 50 µM 0.0122555154781046 0.475571140504288 no 1574 0.495110879097062 2357 2129 K+ channel blocker.
SGTC_3087 9117406 49.47 µM 0.0112042002649812 0.475989931111844 no 1575 0.495530264313787 2310 42546093
SGTC_2047 4141938 200 µM 0.0105269377084832 0.476259732207321 no 1576 0.495800437028498 2376 3807862
SGTC_534 k292-0788 63.4 µM 0.0100467273826229 0.476451040204475 no 1577 0.495992003093203 2393 4146317
SGTC_169 k015-0017 16.025 µM 0.00913162880403094 0.47681561561138 no 1578 0.496357057809998 2374 1840002
SGTC_2705 st078069 42.8 µM 0.00906362195078488 0.476842710330072 no 1579 0.496384187496368 2378 1530061
SGTC_946 3434-1334 87.4 µM 0.00901758911855433 0.476861050404827 no 1580 0.496402551188959 2380 4047976
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.00697246319245682 0.477675903873821 no 1581 0.497218412171933 2386 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.00678868136302387 0.477749133942719 no 1582 0.497291728778452 2392 6728940
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.00671670303852477 0.477777814772221 no 1583 0.497320443320678 2394 77254
SGTC_541 4513-1321 94 µM 0.00664065129282631 0.477808118841778 no 1584 0.497350782900876 2380 747515
SGTC_1539 benzyladenosine 56 µM 0.00645531556187722 0.477881969450617 no 1585 0.497424719574841 2390 92208 A nucleotide analog.
SGTC_3342 9147791 14.508 µM 0.00478803177190302 0.478546364789666 no 1586 0.498089858984695 2401 1838168
SGTC_2291 7917025 104.35 µM 0.0041435372181924 0.478803205279964 no 1587 0.498346972543358 2393 2964612
SGTC_935 2996-0153 430 µM 0.00345345917579787 0.479078221211786 no 1588 0.498622271859686 2398 23738523
SGTC_2807 7945238 51.95 µM 0.00302484717437533 0.479249040435215 no 1589 0.498793262410604 2398 17148797
SGTC_1722 st034304 3.6505 µM 0.00282452469273409 0.479328878357698 no 1590 0.498873179176315 2397 4036148 YLR033W RSC58
SGTC_1555 citronellol 128 µM 0.00215901571422709 0.479594120895907 no 1591 0.499138678016697 2401 8842 A terpine precursor.
SGTC_476 mead acid 10 µM 0.000867936105581774 0.480108713972358 no 1592 0.49965374363427 2405 5312531 An omega 9 fatty acid.
SGTC_729 4092-0585 94.1 µM 0.000605121188776118 0.480213469724798 no 1593 0.499758591587763 2402 2169061
SGTC_2314 7727897 200 µM -0.000239332396471285 0.480550070832715 no 1594 0.499904520188889 2407 900724
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.00101162045384505 0.480857918745618 no 1595 0.499596421898078 2409 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1067 clotrimazole 1.36 µM -0.00113302143169472 0.480906312402393 no 1596 0.499547989943006 2410 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2401 5128683 200 µM -0.001641405053984 0.481108970676034 no 1597 0.499345174418741 2411 708373
SGTC_2848 9016370 25.97 µM -0.00227965026441234 0.481363402915234 no 1598 0.499090551912702 2412 7894410
SGTC_514 4466-0038 2.65 nM -0.00235612199465757 0.481393888376929 no 1599 0.499060044188212 2423 5722064
SGTC_638 3970-0837 4.09 µM -0.00346669559528727 0.481836630809888 no 1600 0.49861699132392 2420 4118451 YLR208W SEC13
SGTC_1799 st045822 46.1415 µM -0.00472420673634709 0.482337978532243 no 1601 0.498115321201934 2415 3674992
SGTC_2612 dictamnine 15.46 µM -0.00591892520748663 0.482814317800336 no 1602 0.497638704267686 2429 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_870 0573-2213 57.6 µM -0.00604294881637473 0.482863767950828 no 1603 0.497589226891315 2419 3916321
SGTC_65 0798-0905 34.986 µM -0.00642349151361739 0.483015497911509 no 1604 0.497437415270002 2422 3602145
SGTC_1013 4112-3890 241 µM -0.00740944351855469 0.483408628022576 no 1605 0.497044086752761 2420 705171
SGTC_19 0279-0214 38.434 µM -0.00758808797651142 0.483479860930605 no 1606 0.496972819929165 2419 3566274 YBR002C RER2
SGTC_2553 4-methylesculetin 85.09 µM -0.00764231330528469 0.483501482908448 no 1607 0.496951187780099 2411 5319502
SGTC_707 0865-0008 204 µM -0.00914265823650943 0.484099754176226 no 1608 0.496352657886727 2422 723043
SGTC_1201 1889-3372 45.9 µM -0.00916089539681596 0.484107026572913 no 1609 0.496345382617083 2430 5392199
SGTC_519 k048-0011 62.8 µM -0.0095135544557815 0.484247656771648 no 1610 0.496204698141459 2460 6836379
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.00978193682677132 0.484354681186846 no 1611 0.496097634049503 2421 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1950 st077106 7.18 µM -0.0106533191918981 0.4847021751842 no 1612 0.495750020938519 2457 13831864
SGTC_3127 9126946 49.47 µM -0.0114066149009363 0.48500258739702 no 1613 0.495449517717837 2445 27243249
SGTC_891 0929-0073 133 µM -0.0116637082778422 0.485105117470509 no 1614 0.495346959123508 2454 5603632
SGTC_2153 5569715 200 µM -0.0127954087362878 0.485556456665466 no 1615 0.494895509747095 2428 2054701
SGTC_996 3970-0799 1.8 µM -0.0132214983286237 0.485726392441035 no 1616 0.494725538976582 2401 6615648 YGL040C HEM2
SGTC_2754 granisetron 64.02 µM -0.0148334952362559 0.486369322549688 no 1617 0.494082508591738 2441 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2226 7298446 200 µM -0.0149124568773829 0.48640081659634 no 1618 0.494051010938489 2435 3283010
SGTC_1296 1068-0102 11.9 µM -0.0162452701738829 0.486932425131224 no 1619 0.493519359922008 2444 767053
SGTC_1147 3809-1045 12.3 µM -0.0185668694528232 0.487858477684786 no 1620 0.492593316312354 2443 325925
SGTC_1733 st037357 54.9 µM -0.0189925012918601 0.488028263351018 no 1621 0.492423543717207 2451 1272339 YGL099W LSG1
SGTC_1753 st043925 64 µM -0.0191148494769814 0.488077068768465 no 1622 0.492374742712487 2435 670181
SGTC_2653 dihydrofissinolide 100 µM -0.0191658593804672 0.488097416974602 no 1623 0.492354396432573 2460 6857746
SGTC_2046 4110841 106 µM -0.0198368427491656 0.48836507978272 no 1624 0.492086763697936 2444 44119630 YMR134W ERG29
SGTC_98 0074-0023 107.663 µM -0.02023064064265 0.488522172637098 no 1625 0.491929692592777 2467 3563821
SGTC_1708 st033234 31.827 µM -0.0231639096376295 0.489692359230317 no 1626 0.490759763407431 2500 674664
SGTC_517 1365-0151 113 µM -0.0236395362305893 0.489882112425011 no 1627 0.490570067801227 2532 768657
SGTC_671 0560-0003 407 µM -0.0238141423298392 0.489951772826757 no 1628 0.490500429650515 2487 3238678
SGTC_1189 1431-2119 7.28 µM -0.0241804923000792 0.490097931865379 no 1629 0.49035431923523 2439 3107275
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.0247453848013366 0.490323304060591 no 1630 0.490129027157051 2457 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2620 irigenin 100 µM -0.0253242419998386 0.490554250882102 no 1631 0.48989816890508 2478 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2526 patulin 37.61 µM -0.0253549084202724 0.490566485961613 no 1632 0.489885938700482 2484 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1893 st059353 36.1 µM -0.0257841925835982 0.490737759759191 no 1633 0.489714735074517 2484 3112488
SGTC_172 1112-0046 2.638 µM -0.0263435023305416 0.490960913116252 no 1634 0.489491678548237 2463 2802135 YIL048W NEO1
SGTC_2611 pyromycin 23.93 µM -0.0264002122920592 0.490983539411198 no 1635 0.489469062412715 2466 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2248 tofa 1.1 µM -0.0266301464575584 0.491075279467517 no 1636 0.489377364192691 2453 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2118 5526350 200 µM -0.0269351545763127 0.491196973558727 no 1637 0.489255727192291 2503 743594
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.0272101336508022 0.491306687172356 no 1638 0.48914606660762 2445 66535 A nucleotide analog.
SGTC_657 3534-0529 86.7 µM -0.0292113293863492 0.492105161455336 no 1639 0.488348022773402 2455 1049549
SGTC_1631 benzylvanillin 81.9 µM -0.030267281005221 0.492526497619123 no 1640 0.487926945293301 2517 75506
SGTC_2895 9054447 58.44 µM -0.0304111214436126 0.492583892171919 no 1641 0.487869587664826 2458 2697450
SGTC_2154 5570129 200 µM -0.0304891758041122 0.492615037129618 no 1642 0.487838462913221 2457 673366
SGTC_495 decylubiquinone 155 µM -0.0310281141443234 0.492830083499858 no 1643 0.487623559308961 2509 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1229 0139-0193 12.2 µM -0.0311790991640322 0.492890329692898 no 1644 0.487563354130272 2472 3090752
SGTC_665 3914-0008 307 µM -0.0312262876023382 0.492909158903907 no 1645 0.487544537829169 2475 1069549
SGTC_1752 st044819 83.042 µM -0.0314028706375595 0.492979619507163 no 1646 0.487474125922032 2485 441209 YML126C ERG13
SGTC_3277 9138724 49.47 µM -0.0320714920040608 0.49324641643931 no 1647 0.487207518897922 2494 15943418
SGTC_158 k038-0087 26.446 µM -0.0340688829832892 0.494043443767241 no 1648 0.486411110927951 2472 X158
SGTC_50 0929-0078 56.389 µM -0.0344082207507106 0.494178853595178 no 1649 0.486275814071878 2568 1377751
SGTC_518 1021-0119 62.6 µM -0.0349602951030823 0.494399155560494 no 1650 0.48605570071135 2497 1097762
SGTC_1657 st012939 43.4 µM -0.0360763638973821 0.494844521278738 no 1651 0.485610734467054 2508 24207257
SGTC_2950 9072895 21.46 µM -0.0363057259299864 0.494936048696773 no 1652 0.485519292159733 2495 17332245
SGTC_2257 7960413 200 µM -0.0363512819916811 0.494954227974174 no 1653 0.485501129909458 2511 2974689 YIL048W NEO1
SGTC_2003 4023581 200 µM -0.0365426953138515 0.495030612124805 no 1654 0.485424817745055 2526 16641307
SGTC_1234 0326-0494 15.5 µM -0.0367692635034028 0.495121025182529 no 1655 0.485334490819807 2523 1547813
SGTC_1956 st077085 54 µM -0.0379513645919364 0.495592751911485 no 1656 0.484863229749562 2502 24208685
SGTC_977 1348-1378 135 µM -0.039102283902328 0.496052041233383 no 1657 0.484404420036349 2465 X977
SGTC_912 3474-0017 2.18 µM -0.039456393005926 0.496193354158403 no 1658 0.484263259881431 2517 3360550
SGTC_2777 climbazole 1.536 µM -0.039659773784896 0.496274516741771 no 1659 0.484182186148431 2475 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_868 0527-0199 213 µM -0.0398845825551583 0.49636423071138 no 1660 0.484092571330725 2522 2849450
SGTC_1367 1812-0510 76.9 µM -0.0400003937142223 0.496410447302437 no 1661 0.484046406203526 2495 1142582 YDR527W RBA50
SGTC_849 0386-0493 241 µM -0.0404650316473044 0.496595870165728 no 1662 0.483861192449364 2486 726119
SGTC_1968 st069590 43.6 µM -0.0406972194526252 0.496688529532999 no 1663 0.483768639158085 2494 6384066
SGTC_3346 9158254 43.5805 µM -0.0409447550818137 0.496787313964856 no 1664 0.483669968973883 2511 17639500
SGTC_2854 9024559 71.43 µM -0.0411405792843858 0.496865461976432 no 1665 0.483591912191116 2510 3163529
SGTC_2497 7-hydroxyflavone 100 µM -0.0419072638613929 0.497171425670192 no 1666 0.48328631288137 2501 5281894
SGTC_1622 st003707 19.4 µM -0.0424315756772721 0.49738066572473 no 1667 0.483077328629089 2571 10140899
SGTC_1729 st035615 45.989 µM -0.0425783584094646 0.497439243263792 no 1668 0.483018823664762 2607 17385451
SGTC_769 0302-0231 76 µM -0.0453899686303852 0.498561300013003 no 1669 0.481898238310725 2518 571869 YER009W NTF2
SGTC_2284 7945075 39.21 µM -0.0454367430398466 0.498579966854238 no 1670 0.481879597253471 2535 1245402
SGTC_2650 prasterone 100 µM -0.0455610397631997 0.498629571497654 no 1671 0.481830061335156 2477 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.0462815330441 0.498917108129301 no 1672 0.481542929015753 2485 2724 A muscle relaxant with antifungal properties.
SGTC_2569 tetrandrine 100 µM -0.0467157714554913 0.499090405585485 no 1673 0.481369880132819 2528 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1244 0416-0015 52.5 µM -0.0475576325405942 0.499426379051533 no 1674 0.481034399066177 2508 96201
SGTC_2664 lyso-paf C-16 73.48 µM -0.047862061711917 0.499547872039502 no 1675 0.480913087543848 2493 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_276 colchicine 750 µM -0.0480418432691036 0.499619620107155 no 1676 0.480841447491113 2576 2833 A microtubule depolymerizer.
SGTC_642 0335-0876 158 µM -0.0483237191279931 0.499732112471796 no 1677 0.480729125751226 2503 6812350
SGTC_689 0833-0039 98 µM -0.0485488337767227 0.499821952317197 no 1678 0.480639423286099 2529 5374726
SGTC_1678 st019265 80.2 µM -0.0494411135080283 0.499821952317197 no 1679 0.480283882182849 2498 5367020
SGTC_3270 9137563 49.47 µM -0.0495330987162733 0.499785242412985 no 1680 0.480247230301357 2629 17015724
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.0497422150439683 0.499701787259294 no 1681 0.480163907669314 2467 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_80 0159-0065 512.242 µM -0.0501468819652065 0.499540290870888 no 1682 0.480002670151614 2486 1548079
SGTC_296 1222-0039 74.9 µM -0.0502469413512726 0.499500358708556 no 1683 0.4799628024915 2526 5984176
SGTC_776 4476-4378 112 µM -0.0505895246110753 0.499363639037945 no 1684 0.47982630514358 2578 2892008
SGTC_2359 9039622 200 µM -0.0506914988775934 0.499322942701992 no 1685 0.479785675427255 2517 6463596
SGTC_1250 0485-0349 40.2 µM -0.0507282084959757 0.499308292468754 no 1686 0.47977104922604 2518 6842794 YDL195W SEC31
SGTC_799 1310-0557 151 µM -0.0512265025008227 0.499109431243111 no 1687 0.479572516811328 2609 5354492
SGTC_3093 9117344 49.47 µM -0.0512521536199877 0.499099194294295 no 1688 0.479562296920166 2626 24824913
SGTC_1419 3993-2473 62.6 µM -0.0525155525476757 0.498594992984299 no 1689 0.479058951646651 2515 704026
SGTC_432 NS 1619 61.3 µM -0.0528621315737431 0.498456679469412 no 1690 0.478920878406949 2638 4552 A K+/calcium channel activator.
SGTC_564 3555-0129 330 µM -0.0530094512910396 0.498397886850009 no 1691 0.478862188630856 2502 563260
SGTC_1252 0493-0875 34.8 µM -0.0534785685552523 0.49821067092119 no 1692 0.478675303012558 2519 3960963
SGTC_2038 4100038 30.985 µM -0.0536144639348705 0.498156437687877 no 1693 0.478621166266852 2568 3596803
SGTC_2974 9094440 9.66 µM -0.0539147822062349 0.4980365865619 no 1694 0.478501529649173 2703 25236134
SGTC_211 3455-0679 143.504 µM -0.0548345062167134 0.497669543914799 no 1695 0.478135154880691 2544 748649
SGTC_1705 st027868 56.3335 µM -0.0554841948249679 0.497410267928516 no 1696 0.47787636062766 2583 292948
SGTC_1432 4049-0298 68.4 µM -0.0561930708388848 0.497127372842909 no 1697 0.477594000556056 2530 741646
SGTC_2831 7999036 19.48 µM -0.0568269195553723 0.496874420536365 no 1698 0.477341534939152 2614 2988270
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0581272874352965 0.496355482054527 no 1699 0.476823619452466 2632 61125 An anti-inflammatory.
SGTC_1255 0566-0045 221 µM -0.0583167202710251 0.496279885488638 no 1700 0.476748174664972 2586 2788469
SGTC_3095 9117207 49.47 µM -0.0589162645633083 0.496040627494181 no 1701 0.476509401653211 2495 17015229
SGTC_920 mycophenolic acid 780.421 nM -0.0598169148785494 0.495681210900805 no 1702 0.476150726787345 2535 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1932 st074806 40.9 µM -0.0612914160175576 0.495092799137585 no 1703 0.475563563488261 2719 17251235
SGTC_1331 1472-0049 76.2 µM -0.0627852765228728 0.494496672753573 no 1704 0.474968745184332 2512 24051409
SGTC_2576 guaiol 23.12 µM -0.0678504283684805 0.492475518705373 no 1705 0.472952350094549 2644 227829
SGTC_1045 1348-1485 165 µM -0.0686195943287376 0.492168613034829 no 1706 0.472646210804943 2510 6810614
SGTC_716 1683-5115 658 µM -0.0699755486116431 0.491627583777731 no 1707 0.472106560650691 2513 723597
SGTC_197 4544-0043 41.561 µM -0.070571154699037 0.49138994022212 no 1708 0.471869534185713 2536 896523
SGTC_108 0509-0257 621.132 µM -0.0708434865744512 0.491281282313533 no 1709 0.47176116073343 2539 536624
SGTC_49 0717-0965 32.132 µM -0.0708714730304311 0.491270116012033 no 1710 0.471750023746179 2792 5889349 YGL099W LSG1
SGTC_446 go6976 132 µM -0.0713902679615618 0.491063123540711 no 1711 0.471543577444706 2540 3501 A protein kinase C inhibitor.
SGTC_219 mitoxanthrone 164.414 µM -0.0716916349371905 0.490942883114546 no 1712 0.471423656693328 2598 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2119 5528445 120.635 µM -0.0726648579187201 0.490554588958373 no 1713 0.47103640695525 2615 791935
SGTC_2412 st077135 33.4 µM -0.0730659236286869 0.490394575312896 no 1714 0.470876829078799 2818 13258915
SGTC_322 k048-0136 19.3 µM -0.0732769150197089 0.490310396454968 no 1715 0.470792880725468 2627 6823282
SGTC_2477 5967686 25.23 µM -0.0741719929984022 0.489953293638581 no 1716 0.470436765399569 2551 776118
SGTC_2263 7948595 193.29 µM -0.0748007069472983 0.48970246495925 no 1717 0.470186639666357 2536 2971371
SGTC_2591 skatole 100 µM -0.0748296173625615 0.489690931096841 no 1718 0.470175138312761 2601 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1713 st033146 12.748 µM -0.0752212910187829 0.489534673037459 no 1719 0.470019322279955 2562 674619
SGTC_2657 nystatin 74.44 µM -0.0766753655697113 0.488954584776642 no 1720 0.46944090113104 2580 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_598 3937-0236 20.2 µM -0.0781657866632313 0.488360020690478 no 1721 0.468848088504193 2601 1379313
SGTC_1320 1313-0481 95.3 µM -0.0787339145797109 0.488133387818217 no 1722 0.468622134634433 2549 6813365 YLR208W SEC13
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.0789635037371734 0.488041803100407 no 1723 0.468530826092254 2585 5024745
SGTC_3147 9097027 49.47 µM -0.0796464117652014 0.487769390066447 no 1724 0.46825924059386 2580 25236841
SGTC_2766 oltipraz 83.91 µM -0.0796943213428932 0.487750279076961 no 1725 0.468240188000641 2593 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1792 st045773 43.6 µM -0.0804385540460572 0.487453410482407 no 1726 0.46794423226966 2548 2919270
SGTC_1145 3546-0597 10.2 µM -0.0811646168397325 0.487163796420595 no 1727 0.467655519158355 2597 875334
SGTC_1490 4089-0339 670 nM -0.0815366227408869 0.487015412226097 no 1728 0.467507600544391 2552 742542
SGTC_505 gw-5074 63.9 µM -0.0831102777014624 0.48638773929236 no 1729 0.466881926848771 2662 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2907 7721985 69.9 µM -0.0837465890357355 0.486133947652211 no 1730 0.466628957264518 2593 3267881
SGTC_3041 9091929 49.47 µM -0.0837754047501626 0.486122454688082 no 1731 0.466617501713786 2635 25236887
SGTC_784 4579-0127 173 µM -0.0842937908652932 0.485915701666534 no 1732 0.466411424502742 2761 1948547
SGTC_144 4161-2749 112.381 µM -0.0843445799871063 0.485895445145393 no 1733 0.466391234475163 2543 797501 YMR168C CEP3
SGTC_3006 9075424 71.4286 µM -0.0845107332493854 0.485829177527027 no 1734 0.466325184736111 2575 7465181
SGTC_864 0469-0573 172 µM -0.0846176182725127 0.485786548321458 no 1735 0.466282695973878 2556 689425
SGTC_2193 5925765 200 µM -0.0847858569488554 0.485719449623073 no 1736 0.466215818784894 2630 877370
SGTC_1550 gossypolone 36.6 µM -0.085374373116432 0.485484734678597 no 1737 0.465981883027101 2564 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3130 9127414 49.47 µM -0.0858058944049934 0.48531263640332 no 1738 0.465810360352878 2544 1494646
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.0861042388709587 0.485193652983504 no 1739 0.465691777004951 2568 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1024 4507-0395 26 µM -0.0861546694807201 0.485173540769854 no 1740 0.465671732588123 2705 4201836
SGTC_899 1083-0020 478 µM -0.0867699280180837 0.484928172782469 no 1741 0.465427195704203 2731 767123
SGTC_176 1486-1328 72.834 µM -0.0879291150194432 0.4844658991539 no 1742 0.46496650789079 2624 22310231
SGTC_953 1188-0045 9.7 µM -0.0880422559745403 0.484420780639768 no 1743 0.464921545554974 2655 6144426
SGTC_2955 9076254 12.21 µM -0.0883120239474516 0.484313202982235 no 1744 0.464814341283924 2570 16459619
SGTC_3251 9135047 49.47 µM -0.088313620419565 0.484312566346931 no 1745 0.464813706862503 2669 17682963
SGTC_942 3253-1115 227 µM -0.0890591956184479 0.484015252996791 no 1746 0.464517432832277 2659 46497897
SGTC_164 4100-3994 89.624 µM -0.0900351179081843 0.483626097491543 no 1747 0.464129654044337 2551 4615967
SGTC_367 0335-0881 7.1 µM -0.0907950309807791 0.483323087880617 no 1748 0.46382772922353 2648 23828853
SGTC_212 3807-4682 38.772 µM -0.0911480479598802 0.483182328286427 no 1749 0.463687477377553 2636 3125501 YBL034C STU1
SGTC_41 0478-0632 82.643 µM -0.0913709746472885 0.483093441090835 no 1750 0.463598912064809 2550 3750424
SGTC_2273 7815444 169.05 µM -0.0916714982230675 0.482973615144859 no 1751 0.463479521568693 2561 2824616
SGTC_174 3553-0389 74.3 µM -0.0920457803515617 0.482824382049324 no 1752 0.463330833245641 2669 738071
SGTC_1829 berberine 14.4 µM -0.0931838188439282 0.482370640262223 no 1753 0.462878764571861 2729 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2861 9024595 19.48 µM -0.0932593101731553 0.482340542282966 no 1754 0.462848778465848 2536 16482810
SGTC_2387 9077560 195.08 µM -0.0938709875092568 0.482096673607703 no 1755 0.462605820330085 2555 5303272
SGTC_1640 st009078 66.4 µM -0.0941625498155072 0.481980433442241 no 1756 0.462490016734639 2617 690618
SGTC_1 0258-0098 57.368 µM -0.0946027409549415 0.481804940785365 no 1757 0.462315186317826 2596 6790032 YDR047W HEM12
SGTC_2678 equilin 100 µM -0.0967363585334018 0.480954374019354 no 1758 0.461467882643943 2602 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2521 angolensin 13.4 µM -0.0973438725533067 0.480712204210414 no 1759 0.461226658077032 2692 821428 A flavenoid.
SGTC_2922 7999257 32.47 µM -0.0979011066554581 0.480490083451696 no 1760 0.461005410613073 2576 2988377
SGTC_145 3737-0113 38.366 µM -0.0984025268159582 0.480290216031693 no 1761 0.460806334155432 2678 6849351
SGTC_1634 st006576 41 µM -0.10066117291576 0.479389975797977 no 1762 0.45990971714505 2627 3915356
SGTC_1795 st049545 62.3 µM -0.102412923023152 0.478691843862263 no 1763 0.459214463258841 2570 5291882
SGTC_666 0272-0154 136 µM -0.102693396807045 0.478580071545578 no 1764 0.459103157260889 2623 6870312
SGTC_3184 9108758 49.47 µM -0.102699110607335 0.478577794542058 no 1765 0.459100889773007 2561 902885
SGTC_205 1486-1330 71.903 µM -0.103417555316113 0.478291493118489 no 1766 0.458815789861823 2577 4118834
SGTC_1141 3253-0389 52.6 µM -0.103826539568902 0.478128517200664 no 1767 0.458653502378795 2567 5402031
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.104059702537767 0.47803560584809 no 1768 0.458560984951995 2585 229346 A bile salt which induces apoptosis.
SGTC_1760 st045453 10.4495 µM -0.104416379683637 0.477893478574361 no 1769 0.458419462313133 2604 3323419 YIL048W NEO1
SGTC_2937 9044753 11.33 µM -0.104577030503089 0.477829463999588 no 1770 0.458355720874985 2601 6465530 YGL099W LSG1
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.105752446388593 0.4773611132277 no 1771 0.457889383707525 2630 688788
SGTC_3186 9110464 49.47 µM -0.107631455255087 0.476612477263704 no 1772 0.457144022119785 2705 17018021
SGTC_2148 5546263 113.568 µM -0.10792247222972 0.47649653740203 no 1773 0.457028595485874 2598 792097
SGTC_2661 dactinomycin 12.96 µM -0.108050100337164 0.476445691561648 no 1774 0.456977975242066 2603 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2341 7987486 176.74 µM -0.108071477742903 0.476437175041275 no 1775 0.456969496539343 2644 1258686
SGTC_1942 st076330 65.2 µM -0.10833818661975 0.47633092210107 no 1776 0.456863716161705 2744 24208414
SGTC_2641 levomentholum 100 µM -0.111684298801469 0.474998025105297 no 1777 0.455536864587741 2597 16666
SGTC_2220 6782180 200 µM -0.112658860708192 0.474609868119375 no 1778 0.455150508968135 2609 833803
SGTC_1514 1189-1591 158 µM -0.114455531666967 0.473894337834572 no 1779 0.454438347633176 2798 767698 YMR146C TIF34
SGTC_330 1488-0319 80.1 µM -0.114793500094882 0.473759750105822 no 1780 0.454304400585553 2679 6846614
SGTC_1350 1495-0454 146 µM -0.116118520042895 0.473232122083674 no 1781 0.453779305614803 2730 1069057
SGTC_3128 9127691 49.47 µM -0.117132466318576 0.472828396457574 no 1782 0.453377541204866 2772 41316314
SGTC_231 b-estradiol 524 µM -0.117366029615369 0.472735401892335 no 1783 0.453285001213498 2615 450 A steroid.
SGTC_181 1447-1644 8.07 µM -0.117958368727036 0.472499565355238 no 1784 0.453050322230503 2631 534600
SGTC_2934 9036370 36.88 µM -0.118445400288901 0.47230566365429 no 1785 0.452857377352089 2706 6462800
SGTC_3202 9113761 49.47 µM -0.118525884296065 0.472273621216091 no 1786 0.452825493472541 2798 4798415
SGTC_1587 estradiol valerate 56.1 µM -0.11906251583334 0.472059981096737 no 1787 0.452612913739425 2636 13791 A steroid.
SGTC_2243 6634756 200 µM -0.120539378673316 0.47147206413661 no 1788 0.452027943684343 2895 885676
SGTC_1697 st025554 27.742 µM -0.120569815295892 0.471459948422729 no 1789 0.452015889144557 2608 1269519
SGTC_2293 7624732 200 µM -0.121967020586488 0.470903800364341 no 1790 0.451462568494105 2610 894453
SGTC_2551 apiole 73.87 µM -0.122145315584287 0.470832835313377 no 1791 0.451391966945377 2606 10659 A possible DNA adduct former.
SGTC_1015 4130-4525 82 µM -0.123202241840411 0.470412176169533 no 1792 0.450973475181662 2644 1363237
SGTC_1450 4112-4260 37.6 µM -0.123444359620957 0.470315817352447 no 1793 0.450877615885594 2599 1633175
SGTC_1935 st074532 41.6 µM -0.123638314730223 0.47023862772462 no 1794 0.450800827225747 2760 2829742
SGTC_334 1502-1024 68.5 µM -0.123886866582452 0.470139711496592 no 1795 0.450702425891883 2719 3296216
SGTC_2616 abietic acid 100 µM -0.126989757454082 0.468905010465043 no 1796 0.449474252641602 2654 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2023 5144124 124 µM -0.129033922415617 0.468091759834654 no 1797 0.448665403492915 2658 2830192
SGTC_687 k029-0044 34.9 µM -0.129925914495852 0.467736931213031 no 1798 0.448312520631879 2695 5829338
SGTC_1906 st060206 94.7 µM -0.130565600453905 0.467482484084396 no 1799 0.448059478289287 2666 5133468
SGTC_2703 st077852 53.4 µM -0.13141524104362 0.467144544109964 no 1800 0.447723416306173 2772 6281836
SGTC_1131 3454-3128 32.3 µM -0.131900328828887 0.466951613656871 no 1801 0.44753156426691 2829 710982
SGTC_3340 9146634 11.102 µM -0.13230621298764 0.466790190253121 no 1802 0.447371046662945 2697 4907387
SGTC_2353 9059630 146.67 µM -0.132639469431963 0.466657655559661 no 1803 0.447239258048652 2736 4779114
SGTC_122 0236-0016 402.397 µM -0.137474616985595 0.464735160955357 no 1804 0.445327827472894 2662 6808838
SGTC_1974 st069448 26.9 µM -0.137782398961943 0.464612811685271 no 1805 0.445206197634235 2739 6323587 YNR016C ACC1
SGTC_3078 9116413 49.47 µM -0.138449935099712 0.464347464712388 no 1806 0.444942417234298 2621 17177322
SGTC_3103 9120822 49.47 µM -0.139696779600801 0.463851884044425 no 1807 0.4444497854814 2863 17141819
SGTC_1299 1079-1439 3.74 µM -0.14233357044916 0.462804029962473 no 1808 0.44340826553509 2675 323161
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.144192690247905 0.462065375091207 no 1809 0.442674156481687 2694 115019
SGTC_1318 1280-3875 124 µM -0.1444729094072 0.461954051295836 no 1810 0.442563523583832 2729 373245
SGTC_3164 9100705 49.47 µM -0.146045750716625 0.461329257848749 no 1811 0.441942635874438 2812 17174235
SGTC_2812 7970281 58.44 µM -0.146811818852084 0.461024980399156 no 1812 0.441640277838742 2789 2233435
SGTC_3052 9092717 49.47 µM -0.147803066087973 0.460631297113528 no 1813 0.441249094764929 2827 25237534
SGTC_697 0508-1955 564 µM -0.147833838375785 0.460619076221702 no 1814 0.441236951789387 2720 6243113
SGTC_1425 4048-4433 7.33 µM -0.14866954863611 0.460287196904626 no 1815 0.44090719541233 2705 23734946
SGTC_1469 k284-2957 126 µM -0.151120756478517 0.4593139276278 no 1816 0.43994022961723 2700 23884841
SGTC_1718 roemerine 11.9335 µM -0.151506958983266 0.459160605295196 no 1817 0.439787910865714 2754 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1562 morin hydrate 59.1 µM -0.151673278623068 0.45909457829472 no 1818 0.439722316935696 2851 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2832 7992762 51.95 µM -0.152092614654278 0.458928111684895 no 1819 0.439556944547813 2667 2985177
SGTC_1654 st012436 41.8 µM -0.152144307962052 0.458907591147156 no 1820 0.439536559130997 2693 4323132
SGTC_1802 st050112 57.9 µM -0.152228392114403 0.458874212746679 no 1821 0.439503400626322 2653 4662563
SGTC_3159 9100096 49.47 µM -0.15246518881101 0.458780214488 no 1822 0.439410022357995 2621 25236875
SGTC_2072 5231554 129 µM -0.152584026543736 0.458733041809876 no 1823 0.43936316122738 2772 789545
SGTC_2761 levamisole 97.89 µM -0.153038126090055 0.458552792200237 no 1824 0.439184104568662 2754 26879 An alkaline phosphatase inhibitor.
SGTC_3227 9130768 49.47 µM -0.153585592187855 0.458335493141944 no 1825 0.438968248954877 2696 17720899
SGTC_1963 st076565 50.3 µM -0.155216763815912 0.457688126098131 no 1826 0.438325216419368 2681 4914280
SGTC_1596 piperlongumine 63 µM -0.156230613220128 0.457285813675626 no 1827 0.437925623571658 2849 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1474 0330-0125 5.35 µM -0.156699129246919 0.457099913431704 no 1828 0.437740986681631 2715 X1474
SGTC_546 peri-Naphthalide 147 µM -0.157533571499588 0.456768842336539 no 1829 0.437412175981539 2783 223824 A penicillin ester.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.157964220113039 0.456597991058952 no 1830 0.437242496445188 2681 16623 A steroid.
SGTC_2413 inermin 26.06 µM -0.161432532774146 0.455222302140826 no 1831 0.43587637262209 2990 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2984 9022109 38.96 µM -0.162202253683987 0.454917068385278 no 1832 0.435573292559743 2682 6459207
SGTC_3 0833-0587 95.581 µM -0.163022025829257 0.454592016023776 no 1833 0.435250546275919 2712 5382644
SGTC_2927 9011802 47.9 µM -0.163188987683115 0.454525816780789 no 1834 0.435184818268393 2798 43912568
SGTC_3339 9145883 14.936 µM -0.164571355064346 0.453977766177216 no 1835 0.434640689548648 2806 2030670
SGTC_889 0919-1524 82.7 µM -0.165224825696339 0.453718722954567 no 1836 0.434383512860327 2767 3905452
SGTC_1489 4065-0444 182 µM -0.167153015427456 0.452954481690938 no 1837 0.433624826233251 2712 2877968
SGTC_1188 1403-0014 4.57 µM -0.167934892911131 0.452644632715631 no 1838 0.433317249679507 2729 9614867
SGTC_417 st075190 100 µM -0.168205620642645 0.452537353167608 no 1839 0.43321075965722 2842 222757
SGTC_797 k781-0471 270 µM -0.169660339095168 0.4519609607038 no 1840 0.432638633304841 2731 23738129
SGTC_129 0088-0017 176.636 µM -0.169727399673274 0.451934392212768 no 1841 0.432612262439276 2741 182446
SGTC_3028 9087778 49.47 µM -0.17046611855915 0.451641736086804 no 1842 0.432321788912709 2714 17217395
SGTC_3150 9097574 49.47 µM -0.173133910619031 0.450585064571438 no 1843 0.431273085304045 2803 17217476
SGTC_1391 3442-0225 151 µM -0.173688098033209 0.450365603113755 no 1844 0.43105529587189 2713 5227075
SGTC_344 k064-0035 6.43 µM -0.173873108216923 0.450292341374347 no 1845 0.430982593610701 2727 5088750
SGTC_536 3852-0578 10.6 µM -0.17424916555433 0.45014343255338 no 1846 0.43083482398968 2884 2869208
SGTC_2369 9071472 200 µM -0.175207802127826 0.449763869467955 no 1847 0.430458176975411 2858 17296037
SGTC_94 0334-0113 514.748 µM -0.176494165440916 0.449254618345857 no 1848 0.429952866019176 2738 6795178
SGTC_1682 st012968 530 nM -0.176789883159339 0.449137560109677 no 1849 0.429836717976635 2744 24207270
SGTC_722 3534-0461 190 µM -0.176870759613555 0.449105546379549 no 1850 0.429804953463772 2767 658262
SGTC_2186 6124449 200 µM -0.177903118446604 0.448696931813315 no 1851 0.429399530874763 2864 3834182 YLR033W RSC58
SGTC_315 k915-0449 187 µM -0.178508641556012 0.448457286986397 no 1852 0.429161767605366 2751 20970215 YNL149C PGA2
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.178649902271889 0.448401383647585 no 1853 0.429106304201161 2797 279621
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.178731075962161 0.448369259961888 no 1854 0.429074433488033 2719 4174840
SGTC_2448 5185112 27.17 µM -0.179325656375144 0.448133970974624 no 1855 0.428841001247839 2858 5718189
SGTC_2905 7799065 20.05 µM -0.179505805244372 0.44806268556911 no 1856 0.428770279719898 2856 1296806
SGTC_2006 4011487 200 µM -0.179889829663426 0.44791073164623 no 1857 0.428619529853418 2855 45595294
SGTC_2757 clomiphene 4.22 µM -0.180712149421458 0.447585375174562 no 1858 0.428296760970103 2893 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_262 fenpropimorph 62.5 µM -0.181490680954406 0.447277376309119 no 1859 0.42799122360588 2725 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3034 9090421 49.47 µM -0.181552793877719 0.447252804862909 no 1860 0.427966849033624 2703 17173761
SGTC_1420 4'-methoxyflavone 42 µM -0.182303082404971 0.446956011890677 no 1861 0.427672439905471 2738 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2213 7173844 200 µM -0.18290582123242 0.446717606925556 no 1862 0.42743595763468 2752 892728
SGTC_47 0149-0135 24.25 µM -0.184184054391494 0.446212083389422 no 1863 0.426934534117428 2703 5239155
SGTC_1223 0764-0573 147 µM -0.184468554435891 0.446099579420731 no 1864 0.426822946869236 2730 1609797
SGTC_3156 9099931 49.47 µM -0.185440958637384 0.445715080374367 no 1865 0.426441592570508 2732 18111053
SGTC_1430 4049-0248 69.1 µM -0.185623257563654 0.445643003095924 no 1866 0.426370106817184 2853 22774488
SGTC_1913 st060213 96.1 µM -0.18575983975928 0.445589002457709 no 1867 0.426316549769932 2873 688959
SGTC_2973 9094665 17.96 µM -0.185919890274016 0.445525724411445 no 1868 0.426253791979503 2967 25237061 YIL048W NEO1
SGTC_2283 7944793 200 µM -0.186420582891341 0.44532777806138 no 1869 0.426057476264774 2803 2970533
SGTC_1976 st070609 63.5 µM -0.187619364214304 0.444853901267362 no 1870 0.425587522682221 2678 682556
SGTC_3146 9095609 49.47 µM -0.188201163417532 0.4446239451127 no 1871 0.425359480254957 2809 17173999
SGTC_1764 st044502 93.5 µM -0.188356815268463 0.444562426870173 no 1872 0.425298475075766 2856 8407
SGTC_2747 doxorubicin 7.63 µM -0.189917989301859 0.443945478553106 no 1873 0.424686697796746 2729 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_832 4083-0019 164 µM -0.190212209354742 0.443829223166226 no 1874 0.424571422049669 2866 1990758
SGTC_1743 st037606 46.3785 µM -0.190258792478769 0.44381081718499 no 1875 0.424553171320677 2759 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1034 k072-0165 12.7 µM -0.190540078522074 0.443699677674804 no 1876 0.424442970142229 2921 5835461
SGTC_2605 digitonin 300 nM -0.1906803069652 0.443644273378151 no 1877 0.424388034180614 2770 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2289 7946404 165.07 µM -0.19107843165146 0.443486980211462 no 1878 0.424232072672819 2758 1246120 YPR165W RHO1
SGTC_1217 1183-1422 255 µM -0.191297495823163 0.443400434997793 no 1879 0.424146261453907 2863 2849664
SGTC_3341 9147222 25.867 µM -0.191907784561355 0.443159343781839 no 1880 0.42390721979245 2865 1939759
SGTC_2028 5153890 36.43 µM -0.192011841293772 0.443118238838169 no 1881 0.423866465000123 2752 2830968 YPR165W RHO1
SGTC_1687 st020778 55.3625 µM -0.19232554195647 0.442994323142292 no 1882 0.423743606131437 2777 4259299
SGTC_2140 5586273 200 µM -0.193767419269158 0.442424835413688 no 1883 0.423178999565885 2722 854421
SGTC_1040 k898-0338 155 µM -0.194113788558115 0.442288050146255 no 1884 0.423043392633487 2947 20969351
SGTC_910 3454-3003 490 µM -0.195316918422366 0.44181297370537 no 1885 0.422572426572151 2803 820824
SGTC_771 0250-0039 27.3 µM -0.195592635776201 0.441704113746442 no 1886 0.422464512375114 2748 3005115
SGTC_611 3453-1652 23.7 µM -0.196854515831555 0.441205948932433 no 1887 0.421970694116263 2838 1560575
SGTC_730 1436-0052 41.2 µM -0.19689484416277 0.441190029649593 no 1888 0.421954914233646 2748 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1925 st057770 10.1 µM -0.197556546858806 0.44092884144636 no 1889 0.421696017617334 2747 5989122
SGTC_2541 muurolladie-3-one 83.07 µM -0.197799980080528 0.440832759607234 no 1890 0.421600780878643 2929 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_44 0929-0055 61.211 µM -0.198211845383823 0.440670206427057 no 1891 0.421439660037201 2768 1379590
SGTC_2424 5537928 59.2 µM -0.198742193206374 0.440460905817223 no 1892 0.42123220845945 2778 5382802
SGTC_2052 5265182 7.135 µM -0.198895613472458 0.440400361943622 no 1893 0.421172200453815 2892 1239884
SGTC_2129 girgensonine 121.053 µM -0.200475754662804 0.439776875924437 no 1894 0.420554259033578 2829 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2365 9042475 200 µM -0.200480817371042 0.43977487853971 no 1895 0.420552279488103 2851 6464479
SGTC_1723 st034307 2.5525 µM -0.200584239117819 0.439734076007015 no 1896 0.420511841482484 2847 867466
SGTC_1937 st074714 47.2 µM -0.202000662259151 0.439175325335762 no 1897 0.419958103222904 2736 17250970
SGTC_3223 9129970 49.47 µM -0.202186812957441 0.439101901583882 no 1898 0.419885340987398 2758 17248386
SGTC_1506 4226-2149 212 µM -0.202721478160365 0.438891024294749 no 1899 0.419676367293626 2871 991114
SGTC_991 3996-0057 64.7 µM -0.205465348850383 0.437809088500963 no 1900 0.418604284074339 2858 715343
SGTC_3299 9121982 43.1275 µM -0.206425636889579 0.437430546653914 no 1901 0.418229223352685 2799 17594604 YPL160W CDC60
SGTC_460 trequinsin 123 µM -0.206710325325595 0.437318334558153 no 1902 0.418118046558631 2825 5537 A vasodilator.
SGTC_1091 telmisartan 47.6 µM -0.207226272952887 0.437114982761415 no 1903 0.4179165748877 2872 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1135 dihydrocapsaicin 536.708 nM -0.207669283501383 0.43694039110155 no 1904 0.41774360150077 2741 107982 A Capsaicinoid.
SGTC_2347 9049783 174.81 µM -0.208551000216062 0.436592940729145 no 1905 0.417399382756608 2930 6467988 YPL169C MEX67
SGTC_655 k060-0012 42 µM -0.209075357960827 0.436386334848137 no 1906 0.417194705546293 2790 5994525
SGTC_1476 4112-3294 3.34 µM -0.209113991836666 0.436371113128876 no 1907 0.417179626129627 2894 704369
SGTC_609 0986-0026 86.3 µM -0.20961685192242 0.436172995220528 no 1908 0.416983362954531 2788 2848610
SGTC_515 4092-1064 102 µM -0.209979274641318 0.436030217057337 no 1909 0.416841924438043 2999 717353
SGTC_813 k007-0158 173 µM -0.213291353089148 0.434725796397386 no 1910 0.415549858810562 2860 6523916
SGTC_3163 9099914 49.47 µM -0.214053062532854 0.434425906594175 no 1911 0.415252839037359 2877 16268368
SGTC_2738 aclarubicin 5.55 µM -0.214148007131748 0.434388528948884 no 1912 0.415215819881712 2863 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2771 fluoxetine 41.05 µM -0.214824635830648 0.434122171794906 no 1913 0.414952022337928 2964 3386 A selective serotonin reuptake inhibitor.
SGTC_2964 9083345 53.42 µM -0.214858604487428 0.434108800706759 no 1914 0.414938779971789 2831 17741579
SGTC_3060 1327-0027 12.5 µM -0.215021068686422 0.434044850939268 no 1915 0.414875446145771 2877 16000455 YPR107C YTH1
SGTC_414 piperonyl butoxide 100 µM -0.215662172567483 0.43379251408573 no 1916 0.414625544618737 2780 5794 A potent inhibitor of cytochrome P450.
SGTC_1693 xanthone 101.9 µM -0.216743758748759 0.433366865728333 no 1917 0.414204021979057 2834 7020 An insecticide.
SGTC_113 0099-0221 2.5 µM -0.216934592189068 0.433291772978078 no 1918 0.414129659399031 2953 89219
SGTC_2133 5320837 200 µM -0.21824067530127 0.432777895485052 no 1919 0.413620797248147 2946 2841355
SGTC_2348 9022543 33.42 µM -0.220747180843968 0.431792031718251 no 1920 0.412644646261937 2929 3162678 YDL140C RPO21
SGTC_636 0kpi-0074 126 µM -0.222141708950598 0.431243716594606 no 1921 0.412101784920496 2880 616434
SGTC_1721 st082152 9.2685 µM -0.2228473269199 0.430966324761539 no 1922 0.411827166241692 2762 5296051
SGTC_1461 k072-0203 53.8 µM -0.223080508456295 0.430874664147281 no 1923 0.411736424062774 2767 5418714
SGTC_55 0767-0285 6.563 µM -0.223780130135062 0.430599674373598 no 1924 0.41146419587951 2925 3116166
SGTC_506 n9-isopropylolomoucine 153 µM -0.226285151434425 0.429615340170413 no 1925 0.410489823169022 2950 6610355
SGTC_390 dec-rvkr-cmk 16.7 µM -0.226299543089394 0.429609686307413 no 1926 0.410484226867841 2860 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1055 3448-0672 86 µM -0.226510110355252 0.429526965125742 no 1927 0.410402348318225 2954 748378
SGTC_299 1273-0059 1.44 µM -0.226903682719381 0.429372358837124 no 1928 0.410249319171942 2906 2848077
SGTC_3077 9117319 49.47 µM -0.228090333832721 0.428906274585568 no 1929 0.409788007268143 2787 17154678
SGTC_188 3229-0966 278.469 µM -0.228123078115013 0.42889341492521 no 1930 0.409775279660141 2853 5722370
SGTC_1084 voriconazole 435 nM -0.228750952553169 0.4286468444442 no 1931 0.409531245083335 2871 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1567 st069303 68.4 µM -0.2297006374034 0.428273949812083 no 1932 0.409162199786703 2921 5581319
SGTC_214 4373-3496 70 µM -0.230635317725926 0.427907009244359 no 1933 0.408799063810883 2855 3779166
SGTC_500 h-89 112 µM -0.230759462372885 0.427858276721467 no 1934 0.408750837814641 3005 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_254 nsc-64875 3.808 µM -0.230986424005358 0.427769186615871 no 1935 0.408662674469376 2957 56993
SGTC_3297 9117502 71.43 µM -0.231414152700547 0.427601298670801 no 1936 0.408496535637112 2819 7453720
SGTC_2041 5107442 45.335 µM -0.232111423944103 0.427327640597964 no 1937 0.408225736068974 2975 793005
SGTC_2971 9092186 9.93 µM -0.234546105434471 0.42637237607903 no 1938 0.407280522123474 2779 25236400
SGTC_1398 3558-0053 112 µM -0.234939283666578 0.426218150165295 no 1939 0.407127929402105 2794 4532369
SGTC_1198 1612-1005 86.7 µM -0.236283080304376 0.425691125266572 no 1940 0.406606507618515 3018 6998509
SGTC_1656 st012921 11 µM -0.236350334335209 0.425664752323087 no 1941 0.406580415960988 2942 6732821
SGTC_3088 9117578 49.47 µM -0.236603474625124 0.425565489068568 no 1942 0.406482212187445 2865 678341
SGTC_882 0843-0131 351 µM -0.236892899391196 0.425452003455692 no 1943 0.406369939345312 2813 5425421
SGTC_425 3825-7017 13.1 µM -0.236953591362345 0.42542820646343 no 1944 0.406346396862393 3079 3397440
SGTC_1997 st073024 93.8 µM -0.237202845607117 0.425330478077491 no 1945 0.406249714415725 2944 686268
SGTC_1839 st053978 48 µM -0.237902182689846 0.425056304313401 no 1946 0.405978481285354 2890 3788398
SGTC_2233 sulbentine 40.3845 µM -0.238154758692852 0.424957291277322 no 1947 0.405880532485343 2844 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1008 4106-0037 6 µM -0.238446802332117 0.424842812322686 no 1948 0.405767285508089 2791 2905394
SGTC_1822 st052468 42 µM -0.239116247185396 0.424580418805245 no 1949 0.405507721863094 2871 2873678
SGTC_3338 9144300 39.5675 µM -0.239631375033315 0.424378533645049 no 1950 0.405308019781516 2902 4901274
SGTC_1763 st044482 94.5 µM -0.240408953545398 0.42407382832064 no 1951 0.405006618896497 2965 88505
SGTC_131 0141-0277 33.849 µM -0.241165698737405 0.423777330404521 no 1952 0.404713347405478 3010 1547771
SGTC_1806 st050005 60.3 µM -0.241333631465534 0.423711539062754 no 1953 0.40464827346061 2834 5194765
SGTC_2692 st077426 47.7 µM -0.241795521364904 0.423530594503794 no 1954 0.404469304696979 2999 25238571
SGTC_1268 0828-0275 2.46 µM -0.241980983572782 0.423457944543692 no 1955 0.404397449162896 2946 745337
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.24286137215811 0.423113110919561 no 1956 0.404056395168221 2827 15053
SGTC_1947 st076332 61.6 µM -0.243934069398148 0.422693032800407 no 1957 0.403640941235126 2918 24208416
SGTC_1179 1021-1431 9.29 µM -0.245127779026112 0.422225668465421 no 1958 0.403178747198207 2907 2840958
SGTC_566 0958-0068 16.5 µM -0.247545331254322 0.421279478131904 no 1959 0.40224310679302 3027 6815365
SGTC_997 3996-0078 137 µM -0.247821556321978 0.421171396991199 no 1960 0.4021362377791 2905 735687
SGTC_2418 pentamidine 31.67 µM -0.247927296843673 0.421130024489597 no 1961 0.402095329650555 2833 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3017 9080681 49.47 µM -0.249488290934607 0.420519364638657 no 1962 0.401491548545592 2921 16451914
SGTC_1769 st044406 64.4 µM -0.250282813653009 0.420208621224424 no 1963 0.401184323161714 2840 670903
SGTC_547 1120-0019 610 nM -0.250384239120383 0.420168956587215 no 1964 0.401145108439369 2824 3676939
SGTC_1652 st011932 78 µM -0.251924317898973 0.419566775100109 no 1965 0.400549781348278 2948 1551076
SGTC_1525 8-methoxypsoralen 92.5 µM -0.252165600984844 0.419472448766317 no 1966 0.400456532751723 3105 4114 Related to psoralen; DNA damaging agent.
SGTC_1905 st060207 84.5 µM -0.252309109150587 0.419416348399078 no 1967 0.400401073887429 2807 1948547
SGTC_3215 9129942 49.47 µM -0.252883707687343 0.419191742138333 no 1968 0.400179039874586 2972 17682944
SGTC_3129 9127257 49.47 µM -0.253982063910943 0.418762476255232 no 1969 0.399754707392028 2877 837894
SGTC_1206 3978-0017 132 µM -0.254327035575404 0.418627672382753 no 1970 0.39962145747022 3139 3873677
SGTC_1046 2001-0062 216 µM -0.255122145267919 0.418317005410051 no 1971 0.399314380259457 2828 739778
SGTC_1785 bathophenanthroline 24 µM -0.255486805029186 0.41817454179234 no 1972 0.399173566799979 2877 72812 An iron chelator.
SGTC_1393 3470-5649 58.2 µM -0.256471458518651 0.417789915521378 no 1973 0.398793408188969 2930 4108395
SGTC_1883 5-benzylidenerhodanine 20 µM -0.256703515231063 0.417699280745473 no 1974 0.398703828851272 2975 1273210
SGTC_1694 st024011 44.9 µM -0.258371390252965 0.4170479849346 no 1975 0.398060147220323 2887 2787533
SGTC_3086 9117350 49.47 µM -0.258905584220929 0.416839433227619 no 1976 0.397854044738213 2832 2679265
SGTC_2676 harmalol 100 µM -0.259550406244148 0.41658772301184 no 1977 0.397605297762108 2956 5459187 A monoamine oxidase inhibitor
SGTC_3250 9135583 49.47 µM -0.259711310116065 0.416524918529911 no 1978 0.397543233862548 3002 7699353
SGTC_502 l-744,832 89.3 µM -0.260668353227369 0.416151406674923 no 1979 0.397174136488409 2987 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1431 4049-0260 9.09 µM -0.261189676910684 0.415947977897322 no 1980 0.39697311926303 2839 3854841
SGTC_1383 3049-0032 20.7 µM -0.261371169426821 0.415877161917922 no 1981 0.396903143974746 3016 712864
SGTC_2281 7943571 200 µM -0.26222299150308 0.415544828741393 no 1982 0.396574764374411 3063 1244024
SGTC_704 1310-0270 142 µM -0.266069436769646 0.414044917144772 no 1983 0.395092866377476 2940 5718033
SGTC_900 1112-0045 141 µM -0.269943594441793 0.412535465532412 no 1984 0.3936018240793 2909 56211 YIL048W NEO1
SGTC_2058 5236698 133 µM -0.270953910727539 0.412142037100618 no 1985 0.393213240267432 2908 766665
SGTC_2079 5212404 121 µM -0.271421872357221 0.41195983751304 no 1986 0.39303329075469 3011 758462
SGTC_220 paclitaxel 373.376 µM -0.27368277496148 0.411079829245614 no 1987 0.392164208061279 2996 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_726 3448-4391 34.2 µM -0.274592348782348 0.410725922893666 no 1988 0.39181472262362 3068 1356692
SGTC_3347 9188721 44.724 µM -0.274786982662761 0.410650202167254 no 1989 0.391739949798641 2959 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2803 7707263 71.43 µM -0.274887846219959 0.41061096333139 no 1990 0.391701202449317 2911 2199229
SGTC_1381 2324-0066 62.1 µM -0.275167565165659 0.410502149267604 no 1991 0.391593752335963 3012 10885928
SGTC_2440 5628896 157.78 µM -0.277794492396617 0.409480579936438 no 1992 0.390585059640527 2892 5522048
SGTC_393 acivicin 6.25 µM -0.278665951479916 0.409141819012522 no 1993 0.390250597288407 2894 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1706 st031321 9.9705 µM -0.278950354010987 0.409031278333885 no 1994 0.390141462351678 2999 6103185
SGTC_1692 fluoroquinolonic acid 71 µM -0.279814423186798 0.40869547906558 no 1995 0.389809942726578 3026 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3325 9138760 55.175 µM -0.280022195325561 0.408614743511087 no 1996 0.389730238204119 2938 43844959
SGTC_2113 5491891 107.031 µM -0.281862146559368 0.407899949682323 no 1997 0.389024607913926 2913 789979
SGTC_2021 4019055 173 µM -0.282010086981457 0.407842490296043 no 1998 0.388967887900538 3048 44827708 YER133W GLC7
SGTC_1866 st057638 64 µM -0.282198139163284 0.40776945454623 no 1999 0.388895792547734 2924 688802
SGTC_1616 st002734 56.1 µM -0.282572617731495 0.407624024022134 no 2000 0.3887522365361 2902 4026101
SGTC_1216 1165-0504 9.65 µM -0.285724170101165 0.406400609983939 no 2001 0.387544695514033 3032 6304004
SGTC_2485 5633444 17.78 µM -0.285971739912615 0.406304543374029 no 2002 0.387449883176224 3010 5724239
SGTC_2826 7992541 19.48 µM -0.287035304594781 0.405891903594833 no 2003 0.387042643970324 2867 2985066
SGTC_2532 xanthone 78.9 µM -0.287141320993502 0.405850777278278 no 2004 0.387002057068322 3008 7020 An insecticide.
SGTC_149 3970-0822 46.1 µM -0.287829594004964 0.405583804875952 no 2005 0.386738591396242 2920 3114250 YBL034C STU1
SGTC_1885 st057546 99.9 µM -0.287993557455923 0.405520211997843 no 2006 0.386675835127642 3075 702008
SGTC_2009 4012297 12.05 µM -0.288010425594348 0.405513669867431 no 2007 0.386669379092106 3026 45595307
SGTC_603 3794-0023 45.9 µM -0.288117563848031 0.405472118036747 no 2008 0.386628374210435 3025 3802260
SGTC_3160 9100216 49.47 µM -0.290093087287953 0.404706134757513 no 2009 0.385872512037798 2885 17191039
SGTC_1527 coumarin 137 µM -0.290901284112472 0.404392872097308 no 2010 0.385563409593164 3108 323 A hepatotoxic, DNA x-linker.
SGTC_2062 5245942 200 µM -0.291502891611186 0.404159724660866 no 2011 0.385333366336848 2898 1376160
SGTC_2730 imipramine 71.33 µM -0.292301822157725 0.403850159124286 no 2012 0.385027932871356 2931 3696 A tricyclic antidepressant.
SGTC_2655 perillic acid 100 µM -0.293097324866193 0.403541981613866 no 2013 0.384723880738906 2939 5702197 An apoptosis inducer.
SGTC_1443 4112-3303 14 µM -0.294317748541075 0.403069306312623 no 2014 0.384257555791351 2932 704433
SGTC_1658 st012944 20 µM -0.29457366862086 0.402970205310298 no 2015 0.384159789726267 3011 24207260
SGTC_1759 st043059 70 µM -0.294867828327051 0.402856304317063 no 2016 0.384047424541895 2915 669426
SGTC_291 SEC14.278 35.5 µM -0.294959998526454 0.402820616973684 no 2017 0.384012218728587 3052 1068044
SGTC_223 busulfan 5 mM -0.295017947520714 0.402798180139821 no 2018 0.383990084716501 3012 2478 A DNA alkylator.
SGTC_1478 0453-0656 35.7 µM -0.295233633664923 0.402714673062516 no 2019 0.383907705254044 2986 5258496
SGTC_2990 9074105 71.4286 µM -0.296989722171217 0.402034934803687 no 2020 0.383237177924518 3000 6502001
SGTC_83 0170-0301 39.027 µM -0.297681353476848 0.401767302682928 no 2021 0.382973188179992 2903 3089716
SGTC_1565 sinapyl alcohol 95.1 µM -0.298000289639229 0.401643903361176 no 2022 0.38285147128074 3021 5280507 A phenol propionate derived from cinnamic acid.
SGTC_3070 9117005 49.47 µM -0.298269869703816 0.401539608012779 no 2023 0.382748599369611 2958 8779016
SGTC_2828 7998861 71.43 µM -0.298456489125919 0.401467412650897 no 2024 0.382677390132892 3048 2988188
SGTC_1933 st074711 15.9 µM -0.299986769372754 0.400875537380837 no 2025 0.382093623821084 2891 17250958
SGTC_1481 3346-2004 36 µM -0.300050495955431 0.400850894409038 no 2026 0.382069319414795 2964 2770522
SGTC_2104 5389443 200 µM -0.300069638249346 0.400843492190386 no 2027 0.382062018908707 3104 2244536
SGTC_989 1501-0895 10.3 µM -0.300091559601011 0.40083501536928 no 2028 0.382053658574463 3028 2830112
SGTC_763 3453-1109 128 µM -0.300382746713843 0.40072241994319 no 2029 0.381942611261937 3095 1560353
SGTC_2727 riluzole 51.77 µM -0.300554644459209 0.400655954870239 no 2030 0.381877060781238 2958 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_294 k038-0071 157 µM -0.301757458538404 0.400190961715887 no 2031 0.381418481548801 2993 24152826
SGTC_2178 5812956 200 µM -0.302103897874432 0.400057058732209 no 2032 0.381286430560642 2892 5403383
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.302417267053693 0.399935947883348 no 2033 0.381166996704246 2939 4620898
SGTC_676 falcarinol 140 µM -0.302714953368452 0.399820907058241 no 2034 0.381053550513407 3132 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_356 1634-0012 32.5 µM -0.303456337637942 0.399534437047532 no 2035 0.380771058560491 3062 735457
SGTC_2312 7706453 155.7 µM -0.303703616867868 0.399438900662662 no 2036 0.380676851112251 2977 976098
SGTC_2318 6029776 164 µM -0.305179198889306 0.398868934583674 no 2037 0.380114837044697 3138 818325
SGTC_336 4111-0029 111 µM -0.305522281583296 0.398736444501657 no 2038 0.379984201227088 2975 3131175
SGTC_340 k038-0059 454 µM -0.305939505603413 0.398575338591011 no 2039 0.379825353021144 2953 23733424
SGTC_2475 5812728 15.03 µM -0.306494499441055 0.398361061353543 no 2040 0.379614083633219 2921 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1253 0550-0034 176 µM -0.306894430888878 0.398206671053762 no 2041 0.379461864086466 3065 5969915
SGTC_1848 st056003 16.4 µM -0.307551437969668 0.397953073387444 no 2042 0.379211838494454 3014 146492
SGTC_2791 5663188 71.43 µM -0.309662742689204 0.397138424822374 no 2043 0.378408718997104 3122 54690634
SGTC_3092 9117248 49.47 µM -0.310139760267445 0.396954429216904 no 2044 0.378227338792282 2988 17141857
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.310388162581593 0.39685862435464 no 2045 0.378132897417641 2946 6708784 An antioxidant flavonoid
SGTC_111 0083-0039 52.457 µM -0.310555235939653 0.396794190291564 no 2046 0.378069381019341 2910 759313
SGTC_1738 st035555 74 µM -0.311946663263313 0.396257677444104 no 2047 0.377540529258172 3071 5331140
SGTC_3133 9127736 49.47 µM -0.312150299367038 0.396179174965274 no 2048 0.377463150760543 3133 27243420
SGTC_469 w7 172 µM -0.312308283568769 0.396118274364931 no 2049 0.377403122651317 2978 45115570 A P450 inhibitor.
SGTC_1661 st013063 9.66 µM -0.3133386505618 0.395721145200455 no 2050 0.377011694300081 2964 721395
SGTC_2978 9011784 42.97 µM -0.313759551527039 0.395558950573111 no 2051 0.376851833648233 3073 2994934
SGTC_2595 hexamethylquercetagetin 100 µM -0.314792152949101 0.395161113205856 no 2052 0.376459735055314 3023 386331
SGTC_3062 9077494 49.47 µM -0.315248040773796 0.394985504947578 no 2053 0.376286666219704 3084 16459633
SGTC_2382 9035899 200 µM -0.315566202219131 0.39486296160686 no 2054 0.376165897225684 2982 6462679
SGTC_22 0964-0034 14.468 µM -0.315684916773301 0.394817240068947 no 2055 0.376120838185834 2999 138402
SGTC_2087 5276107 200 µM -0.315904798887855 0.394732558841558 no 2056 0.376037384665959 2946 144405
SGTC_1727 st034309 9.9045 µM -0.316161498540915 0.394633704697979 no 2057 0.375939964841632 3209 870305
SGTC_795 0685-0265 78 µM -0.317623340525835 0.394070883938027 no 2058 0.375385333559228 2960 302754
SGTC_1666 st014829 29 µM -0.319424972801845 0.393377545542285 no 2059 0.374702138179978 2920 3858230
SGTC_925 2064-1272 59.6 µM -0.320861730180507 0.392824867368901 no 2060 0.374157588302849 2982 6815817
SGTC_1810 st050138 53 µM -0.322389849640636 0.392237281953547 no 2061 0.373578686449502 3096 3444541
SGTC_2825 7998094 58.44 µM -0.32449295856093 0.391429006129316 no 2062 0.372782426184874 3037 2987815
SGTC_1280 0880-0253 10.1 µM -0.324778654945111 0.391319242144024 no 2063 0.372674300217351 2979 6836607
SGTC_2909 7941780 10.49 µM -0.324834801197441 0.391297671882254 no 2064 0.372653052027751 3136 1243215
SGTC_750 4073-0104 132 µM -0.324925545664307 0.391262810388587 no 2065 0.372618711184777 3038 22330957
SGTC_280 3448-3607 3.04 µM -0.326304771069902 0.39073305813711 no 2066 0.372096889410743 3072 626179
SGTC_3073 9114972 49.47 µM -0.327134460675302 0.39041447690414 no 2067 0.371783094303278 3088 41905075
SGTC_2519 cryptotanshinone 88.04 µM -0.327834868049532 0.390145594251588 no 2068 0.371518261028871 3140 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2536 dehydroabietamide 32.04 µM -0.329691380043704 0.38943314375592 no 2069 0.370816583823354 3133 3983547
SGTC_994 3910-0338 138 µM -0.330053371383265 0.389294270048566 no 2070 0.370679817492218 3169 3479481
SGTC_1886 st057356 49.9 µM -0.331547384448302 0.388721259337144 no 2071 0.370115527635623 2978 24207747
SGTC_148 3253-0744 288.01 µM -0.334932308396132 0.387423909677577 no 2072 0.368838074850647 2985 6893655
SGTC_529 4076-0302 30.3 µM -0.335408427059159 0.387241526732757 no 2073 0.368658505949272 3004 5816522
SGTC_378 3970-0959 8.33 µM -0.335703750059467 0.387128412231002 no 2074 0.36854713882241 3122 6615653
SGTC_2708 st078559 56 µM -0.335911934691402 0.387048679192402 no 2075 0.368468638451386 3098 17250902
SGTC_3144 9087057 49.47 µM -0.336308375204626 0.386896858847814 no 2076 0.368319167444078 3142 17249618
SGTC_485 niflumic acid 177 µM -0.336791278419942 0.386711950237817 no 2077 0.368137124099376 3110 4488 A COX2 inhibitor.
SGTC_1121 fusaric acid 630.51 nM -0.337082012090792 0.386600637722438 no 2078 0.368027538503667 3011 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3039 9090270 49.47 µM -0.337402497854737 0.386477944904005 no 2079 0.367906750961691 3136 17173750
SGTC_1397 3532-0190 20.1 µM -0.338311119407197 0.386130155494928 no 2080 0.367564372582184 2928 5322280
SGTC_2652 actinonin 100 µM -0.339125713673099 0.385818434293281 no 2081 0.367257514147785 2984 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1790 st045711 43.5 µM -0.339146961493985 0.385810304364518 no 2082 0.367249511206917 3168 585119
SGTC_2846 9008642 19.48 µM -0.340817680114157 0.38517120442175 no 2083 0.366620419842852 3116 2992898
SGTC_3210 9128157 49.47 µM -0.341658558990846 0.384849660883417 no 2084 0.366303931205409 3085 17590849
SGTC_2748 diazoxide 86.69 µM -0.342907433308183 0.384372250218306 no 2085 0.365834049739301 3075 3019 A potassium channel activatior.
SGTC_2034 5197015 53.07 µM -0.342973247824555 0.384347095977151 no 2086 0.36580929299731 3157 780676
SGTC_332 4112-0506 40.9 µM -0.345354079538277 0.383437472781891 no 2087 0.364914097515321 3018 2790355
SGTC_2390 9097792 176.6 µM -0.346300988928431 0.383075873729532 no 2088 0.3645582627432 3016 4497149
SGTC_2334 9017922 200 µM -0.346457423366047 0.383016145449956 no 2089 0.364499488178869 3141 3163164
SGTC_117 lucigenin 22.078 µM -0.34728958928953 0.38269846271114 no 2090 0.364186885597742 3085 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1612 st002233 45.4 µM -0.347789465299666 0.382507670925197 no 2091 0.363999150918751 3089 1035021
SGTC_545 4218-0007 221 µM -0.350552594182953 0.381453560435031 no 2092 0.362962013252839 3145 2840508
SGTC_1062 mesoridazine 14.2 µM -0.352559930882093 0.380688328884371 no 2093 0.362209190724475 3018 4078 A neuroleptic.
SGTC_1867 st057372 64 µM -0.352756624612178 0.38061337087372 no 2094 0.362135452199887 3051 688837
SGTC_1200 1643-0193 18.4 µM -0.352804422156013 0.380595156385213 no 2095 0.362117534148324 3145 5403974
SGTC_2970 9090938 41.86 µM -0.35387595055176 0.380186892365792 no 2096 0.361715925502427 3229 17217104
SGTC_639 0833-0042 114 µM -0.354808510986683 0.379831685252291 no 2097 0.36136652592585 3054 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2081 5214970 32.255 µM -0.355943352136776 0.379399567282549 no 2098 0.360941494394408 3147 2063512
SGTC_3209 9113616 49.47 µM -0.356502750108553 0.379186618480527 no 2099 0.360732046461252 3237 16649353
SGTC_457 grayanotoxin iii 135 µM -0.358507312930614 0.378423833042315 no 2100 0.359981848088101 3126 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_449 xestospongin c 11.1929 µM -0.358611829000487 0.378384075070259 no 2101 0.359942748191532 3132 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_817 1391-0715 46 µM -0.359236269922028 0.378146564228874 no 2102 0.359709172790905 3077 1353946
SGTC_2199 6590217 200 µM -0.359691616141903 0.37797339886274 no 2103 0.359538881176128 3071 703109
SGTC_499 genistein 192 µM -0.361876115382815 0.377142988718525 no 2104 0.358722304598361 3111 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_3085 9117376 49.47 µM -0.361968681829468 0.377107813252514 no 2105 0.3586877170313 3127 16480349
SGTC_1406 3909-7906 11.9 µM -0.361992552905521 0.377098742353227 no 2106 0.358678797762214 3079 X1406
SGTC_255 tunicamycin 200.472 nM -0.365724436143506 0.375681480937454 no 2107 0.357285355048998 3113 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2054 5233173 129 µM -0.366621397660712 0.375341089937359 no 2108 0.356950722488776 3188 6889
SGTC_1319 1306-0155 43.7 µM -0.366868405833661 0.37524736898868 no 2109 0.3568585896 3062 3122360
SGTC_2882 9058044 58.44 µM -0.36695143551523 0.375215867147937 no 2110 0.356827621793195 3126 18076804
SGTC_57 miconazole 162.5 nM -0.367478686906769 0.375015844989817 no 2111 0.35663099343021 3095 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3113 9123498 49.47 µM -0.367977387093837 0.374826685164639 no 2112 0.35644504774968 3122 8897275
SGTC_959 1222-0044 107 µM -0.368560657370735 0.374605485627198 no 2113 0.35622761250212 3190 6083612
SGTC_700 3453-2283 142 µM -0.370003499920412 0.374058479124717 no 2114 0.35568994131083 3232 565664
SGTC_2872 9044037 25.97 µM -0.370015032290476 0.374054108024 no 2115 0.355685644960475 3035 6465195
SGTC_669 0108-0021 26.2 µM -0.370930915592918 0.373707013605124 no 2116 0.355344493930662 3365 17201
SGTC_749 1000-0129 128 µM -0.371133272571214 0.373630339714374 no 2117 0.355269135001925 3233 708470
SGTC_2172 5754775 163.918 µM -0.372193689048161 0.373228625396712 no 2118 0.354874322265436 3050 2263357
SGTC_3168 9103419 49.47 µM -0.372491419004596 0.373115862021828 no 2119 0.35476349987163 3136 16649256
SGTC_3350 9150499 3.57 µM -0.37450766474506 0.372352507909936 no 2120 0.354013327593756 3025 4910996 YPR165W RHO1
SGTC_408 cantharidin 100 µM -0.374782142637004 0.372248628803868 no 2121 0.353911248006066 3082 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2267 7931562 200 µM -0.37558839302076 0.371943548466185 no 2122 0.353611460534643 3007 934880
SGTC_2192 5915882 198.485 µM -0.376839126745865 0.37147043741053 no 2123 0.353146580839285 3100 2876149
SGTC_2405 ticlatone 3.52 µM -0.377531396716684 0.371208658061236 no 2124 0.352889368208591 2888 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1333 1482-0047 286 µM -0.377896239455722 0.371070718082942 no 2125 0.352753838074604 3196 3811116
SGTC_358 0075-0058 9.45 µM -0.377961264002288 0.371046135298996 no 2126 0.352729685010887 3285 1069125
SGTC_1480 1070-0044 41.2 µM -0.37988084263163 0.370320668554705 no 2127 0.352016934296538 3145 3124987
SGTC_866 0495-0101 262 µM -0.38043434994719 0.370111566940582 no 2128 0.351811510216425 3055 635694
SGTC_2564 betulinic acid 100 µM -0.380519139444191 0.370079538917837 no 2129 0.351780045969942 3333 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_472 calcifediol 10 µM -0.381357637039671 0.369762856955572 no 2130 0.351468945433716 3120 5283731 A vitamin D metabolite.
SGTC_644 1498-1197 63.3 µM -0.381384361706483 0.369752765092124 no 2131 0.351459031645505 3172 6741615
SGTC_735 3076-0345 636 µM -0.38216715451163 0.369457203921782 no 2132 0.351168691507734 3228 2888990
SGTC_14 0354-0009 295 µM -0.382720402636214 0.369248359059376 no 2133 0.350963542532611 3082 1713507
SGTC_1082 camptothecin 424.86 nM -0.382853614160161 0.369198078988524 no 2134 0.350914153085025 2900 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1670 st016595 4.04 µM -0.38306877018292 0.369116874073465 no 2135 0.350834387250022 3149 597879
SGTC_2473 5854593 8.94 µM -0.383383778671225 0.368997993039327 no 2136 0.350717614485817 3013 2872951
SGTC_1734 st037168 69.4 µM -0.383619512449879 0.368909037679724 no 2137 0.350630237858885 3153 708907
SGTC_741 4582-0002 126 µM -0.3841015112804 0.36872717479138 no 2138 0.350451605702355 3056 2912688
SGTC_843 0310-0051 143 µM -0.384112607671994 0.368722988359935 no 2139 0.350447493690858 3118 2065037
SGTC_2027 5150920 200 µM -0.389664997883363 0.366630153907765 no 2140 0.348392141109986 3130 786715
SGTC_873 0591-4978 488 µM -0.39039172885368 0.366356522551493 no 2141 0.348123451528664 3273 3305145
SGTC_812 4251-0442 148 µM -0.390489688494171 0.366319643628213 no 2142 0.348087239365729 3216 5723007
SGTC_2225 6654152 15.4 µM -0.390694054210235 0.366242709922044 no 2143 0.348011697155571 3146 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1366 1683-0113 21.9 µM -0.391631631695556 0.365889826763182 no 2144 0.34766520622068 3093 708623
SGTC_364 0083-0097 67.7 µM -0.392318949360009 0.365631207831132 no 2145 0.347411282041582 3210 5207356
SGTC_1408 3909-7976 48.8 µM -0.394908719388053 0.364657297253233 no 2146 0.346455127395338 3146 24152374
SGTC_278 4092-0821 23.9 µM -0.395089679714385 0.364589277750565 no 2147 0.346388352506283 3181 877900
SGTC_125 0133-0007 11.75 µM -0.395121521057775 0.364577309643606 no 2148 0.34637660345141 3246 26541
SGTC_72 0744-0168 198.391 µM -0.395140832766443 0.364570051075882 no 2149 0.34636947774603 3020 677577
SGTC_2563 tomatine 8.54 µM -0.39831252930846 0.363378586507937 no 2150 0.345199912944189 3314 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_3238 9133470 49.47 µM -0.398615942605957 0.363264676724453 no 2151 0.345088106356359 3224 3534688
SGTC_2952 9073731 13.78 µM -0.399743156427434 0.362841595308931 no 2152 0.344672851066162 3117 16457353
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.39987321255758 0.362792791610869 no 2153 0.344624951602772 3243 688664
SGTC_757 1066-0008 322 µM -0.400586455446177 0.362525186119455 no 2154 0.344362309702457 3227 6842497
SGTC_778 3456-2434 196 µM -0.40165360045529 0.362124923586271 no 2155 0.34396948835016 3211 5539063
SGTC_2120 5538279 151.968 µM -0.40304530869667 0.361603151052181 no 2156 0.34345744664374 3129 2058197
SGTC_2809 7964133 12.99 µM -0.404401265409821 0.361095029690487 no 2157 0.342958834911112 3134 1253665
SGTC_1157 4092-0394 27.6 µM -0.404678899547737 0.360991021281298 no 2158 0.342856777110933 3298 3659885
SGTC_3307 9126885 69.2785 µM -0.404683219104134 0.360989403153013 no 2159 0.342855189340485 3100 24824909
SGTC_1155 4088-0394 48.2 µM -0.404704380926804 0.360981475860164 no 2160 0.342847410777058 3089 2326248
SGTC_2011 4012611 177 µM -0.405062331072086 0.360847395532895 no 2161 0.342715847239001 3086 2049887
SGTC_3055 9094636 49.47 µM -0.405460015212269 0.360698451770215 no 2162 0.342569701954736 3296 25236176
SGTC_178 4092-0806 87.505 µM -0.40602963978626 0.360485148346581 no 2163 0.34236041118566 3203 2169044
SGTC_2571 chrysanthemic acid 100 µM -0.40614023050651 0.360443741224804 no 2164 0.34231978368632 3146 2743 An insecticide.
SGTC_2558 carylophyllene oxide 100 µM -0.406791138975318 0.36020006275914 no 2165 0.342080697689382 3166 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_3009 9080819 71.4286 µM -0.408763327873481 0.35946208792806 no 2166 0.341356677327347 3187 17027216
SGTC_556 4058-0063 51.5 µM -0.409674406812185 0.359121347352632 no 2167 0.341022403352259 3167 6615692
SGTC_3243 9134147 49.47 µM -0.410848703153963 0.358682329612136 no 2168 0.340591739208983 3213 24282180
SGTC_3313 9133968 57.047 µM -0.411009376810432 0.358622275304665 no 2169 0.340532829526987 3200 1494643
SGTC_2904 7225135 42.03 µM -0.411147094695002 0.358570803860206 no 2170 0.340482339487136 3238 4446116
SGTC_1029 k015-0030 64.7 µM -0.412380581021584 0.358109908497605 no 2171 0.340030247108748 3235 2208316
SGTC_987 1497-1013 404 µM -0.413759147607548 0.35759504813258 no 2172 0.339525252589007 3221 1676435
SGTC_1006 4099-6547 255 µM -0.414638185705266 0.357266884430645 no 2173 0.339203394924781 3237 3146833
SGTC_719 2810-4230 27.3 µM -0.415281979550713 0.357026609371359 no 2174 0.338967745767668 3176 721079
SGTC_516 3992-2719 87.3 µM -0.41740411525032 0.356234993335415 no 2175 0.338191422658615 3036 5350887 YDR037W KRS1
SGTC_983 1491-0821 12.2 µM -0.418320254838564 0.35589343876135 no 2176 0.337856491244439 3244 46495113
SGTC_1360 1598-0022 39.8 µM -0.419300474649217 0.355528121890032 no 2177 0.337498274864852 3241 761525
SGTC_600 1495-0418 41.6 µM -0.419406997326918 0.355488430076079 no 2178 0.33745935555257 3143 5377768
SGTC_1509 1326-1131 80 µM -0.420980769325242 0.354902203822435 no 2179 0.336884562253914 3226 768313
SGTC_1931 st074438 57.1 µM -0.421965321693972 0.354535634953997 no 2180 0.336525164846949 3196 2787313
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.422569904139055 0.35431060333893 no 2181 0.336304544236357 3117 442882
SGTC_91 0417-1751 58.384 µM -0.424380538299113 0.35363697174739 no 2182 0.335644155833723 3239 6795624
SGTC_99 0109-0120 622.8 µM -0.425931032551712 0.353060487049827 no 2183 0.335079050754081 3358 759414
SGTC_2078 5212016 200 µM -0.426021784749932 0.353026755172624 no 2184 0.335045986055279 3198 1899708
SGTC_892 0929-0076 29 µM -0.426240078163217 0.352945621961244 no 2185 0.334966458165884 3174 5751038
SGTC_865 0488-0499 301 µM -0.426550543085948 0.352830242840505 no 2186 0.334853363422124 3308 9634651
SGTC_2425 5628681 7.85 µM -0.427016544348487 0.352657086632571 no 2187 0.334683638723209 3217 5714958
SGTC_3032 9089427 49.47 µM -0.42791797760384 0.352322219765263 no 2188 0.334355418986819 3232 17173707
SGTC_2581 avocatin a 64 µM -0.428898179552477 0.35195822157948 no 2189 0.333998662544808 3165 6710728 A skin care supplement.
SGTC_2560 caryophyllene 100 µM -0.431361913668685 0.351043912930919 no 2190 0.333102619239503 3160 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_48 0382-0018 55 µM -0.432316731838716 0.350689804733669 no 2191 0.332755614041374 3403 762596
SGTC_1782 st039423 80.636 µM -0.432614728751695 0.350579314784832 no 2192 0.332647343697091 3183 2068169
SGTC_321 4534-3890 65.3 µM -0.432876781929286 0.350482162335915 no 2193 0.332552144217894 3247 699746
SGTC_3318 9139014 38.6185 µM -0.43334415102649 0.350308916239655 no 2194 0.332382383751056 3163 16643984
SGTC_2254 7938975 95.19 µM -0.433706068912531 0.350174780578298 no 2195 0.332250949490902 3342 2969277
SGTC_3198 9112019 49.47 µM -0.435662742167209 0.349449913412426 no 2196 0.331540720768555 3201 45595555
SGTC_1604 st002052 72.4 µM -0.435743415295894 0.3494200390875 no 2197 0.331511451198194 3301 6254834 YHR062C RPP1
SGTC_2648 atorvastatin 78.68 µM -0.436916765946213 0.348985637370678 no 2198 0.331085856200266 3270 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1610 st001799 48.1 µM -0.437556173043932 0.348748997223919 no 2199 0.330854023747352 3097 621897
SGTC_1497 4476-2978 41.3 µM -0.437703392943667 0.348694520485419 no 2200 0.330800654806853 3243 1528379
SGTC_2896 9052656 71.43 µM -0.439021731174188 0.348206826369265 no 2201 0.330322895125881 3247 6469436
SGTC_1073 triclabendazole 3.09 µM -0.439153842422425 0.348157968147728 no 2202 0.33027503384806 3269 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_936 3005-4620 401 µM -0.440377473832848 0.347705556863439 no 2203 0.329831868572991 3356 777207
SGTC_1308 1187-1617 41.4 µM -0.441105755947806 0.347436393146435 no 2204 0.329568218338042 3164 2882570
SGTC_424 splitomicin 100 mM -0.441275363482063 0.347373719416552 no 2205 0.329506829743768 3226 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_837 0091-0265 12.5 µM -0.441448031873717 0.347309918918664 no 2206 0.329444338007047 3177 759367
SGTC_2506 ethyl hematommate 54.16 µM -0.441756102069354 0.347196098571447 no 2207 0.329332853800478 3231 3940691 An allergen.
SGTC_2654 protoveratrine a 100 µM -0.443410709333245 0.346585019438481 no 2208 0.328734345558217 3192 5702278 A heart drug and vasodilator.
SGTC_1066 ketoconazole 628 nM -0.445079110001928 0.345969250082251 no 2209 0.328131292389237 3305 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_985 1493-0307 8.71 µM -0.445676364748459 0.345748915589107 no 2210 0.327915519908227 3328 3278274
SGTC_343 4130-2827 29.8 µM -0.448988865836429 0.344527843929392 no 2211 0.326719844301993 3228 1118244
SGTC_1003 4049-0218 100 µM -0.449653696738315 0.344282965041792 no 2212 0.326480081677176 3333 295161
SGTC_12 0849-0099 9.267 µM -0.450489768376257 0.343975105268966 no 2213 0.326178665046706 3256 6071388
SGTC_2875 9039966 71.43 µM -0.45123452297113 0.343700957488377 no 2214 0.325910265189671 3231 6463691
SGTC_146 3448-8650 53.125 µM -0.452013283630123 0.343414379799199 no 2215 0.325629706445693 3208 2891488 YIL048W NEO1
SGTC_419 nsc-638432 893 µM -0.452026668053482 0.343409455224763 no 2216 0.325624885394315 3236 368090
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.452304206815029 0.343307345477166 no 2217 0.325524922878136 3299 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1098 clofazimine 15.1 µM -0.452583063655887 0.343204762311511 no 2218 0.325424498260014 3311 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2646 retinol 96.75 µM -0.453316841163218 0.342934882530958 no 2219 0.325160303785351 3286 445354 A vitamin A analog and teratogen.
SGTC_2280 7785178 200 µM -0.45343350484685 0.342891981576457 no 2220 0.325118307455111 3201 2954328
SGTC_1149 3909-7961 23.3 µM -0.45348551912245 0.342872854922496 no 2221 0.325099584189257 3229 735261
SGTC_834 0312-0008 75.7 µM -0.454446716014765 0.342519476781126 no 2222 0.324753667456608 3249 6385573 YIL048W NEO1
SGTC_66 0109-0187 42.4 µM -0.454812942432521 0.342384872121414 no 2223 0.324621909168745 3308 759417
SGTC_790 1575-0012 79.1 µM -0.455410810650709 0.342165171715856 no 2224 0.324406859632303 3322 378741 YLR208W SEC13
SGTC_2244 6635614 200 µM -0.455870819676537 0.341996167192866 no 2225 0.324241437051734 3062 836499
SGTC_2395 5646831 180.19 µM -0.456268343159439 0.34185014497239 no 2226 0.324098512663207 3364 6808628
SGTC_2783 7738165 71.43 µM -0.456783485196069 0.34166095314577 no 2227 0.32391333861854 3239 17201110
SGTC_2659 sanguinarine 24.21 µM -0.457586105859851 0.341366260757493 no 2228 0.323624913735734 3176 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1846 st056244 14.8 µM -0.457776509820483 0.341296365705313 no 2229 0.3235565068629 3245 5393182
SGTC_2706 st078239 82.5 µM -0.458393111835598 0.341070055736101 no 2230 0.323335019753517 3286 15434492
SGTC_2253 7938677 135.83 µM -0.458748886515756 0.340939502604275 no 2231 0.323207251846506 3346 2301972
SGTC_1328 1441-0025 69.2 µM -0.458784980465289 0.34092625882967 no 2232 0.323194290738709 3221 4562601
SGTC_1160 4092-0570 10.5 µM -0.461742983810098 0.339841560907072 no 2233 0.322132821303396 3220 4994975
SGTC_3253 9135987 49.47 µM -0.461766764814073 0.339832845784485 no 2234 0.322124293431938 3296 4182430
SGTC_1440 4100-1550 40 µM -0.461775596363612 0.339829609271908 no 2235 0.322121126460844 3252 742806
SGTC_761 k216-0224 480 µM -0.462037485374806 0.339733639739768 no 2236 0.322027219601697 3372 1340404
SGTC_361 000s-0510 1.45 µM -0.462691956703795 0.33949385339117 no 2237 0.321792592215867 3260 660
SGTC_1547 harmine 94.2 µM -0.463426013830727 0.339224985552876 no 2238 0.321529517918327 3271 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_348 k064-0012 10.7 µM -0.463681389346277 0.3391314666981 no 2239 0.321438016404248 3206 5066323
SGTC_2309 7664088 163.95 µM -0.463905489084252 0.339049409238694 no 2240 0.321357729983544 3380 704922
SGTC_2355 9061122 103.12 µM -0.46485456663485 0.338701975024064 no 2241 0.321017804119903 3282 5302957
SGTC_2433 5607874 27.82 µM -0.465631896274977 0.33841751573413 no 2242 0.320739503937896 3208 2252428
SGTC_768 0384-0033 77.3 µM -0.467959162310087 0.337566417845439 no 2243 0.319906896940215 3217 3965305 YMR134W ERG29
SGTC_1516 st013856 110 µM -0.469745268528175 0.336913788753846 no 2244 0.319268510761882 3293 5281404 A mutagen and neurotoxin.
SGTC_1680 diphenhydramine 100 µM -0.470709052415319 0.336561833427702 no 2245 0.318924259524702 3221 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1742 st038235 28.8875 µM -0.470784503212543 0.336534286286046 no 2246 0.318897316055074 3306 564103 YBR002C RER2
SGTC_860 0443-0016 25.1 µM -0.471602136608384 0.336235824022269 no 2247 0.318605400683303 3298 5337942
SGTC_1872 amphotericin b 148 nM -0.471621910148862 0.336228607326648 no 2248 0.318598342432769 3306 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2031 5180455 200 µM -0.471862358435455 0.336140856395086 no 2249 0.318512518647459 3240 29949
SGTC_2000 st075254 36.4 µM -0.471925650339312 0.336117759675503 no 2250 0.318489929334629 3306 17234175
SGTC_938 3126-1755 342 µM -0.472609495297834 0.335868247872437 no 2251 0.318245903440146 3365 1777771
SGTC_2227 7312221 64.1025 µM -0.472946509228441 0.335745309530958 no 2252 0.318125671079403 3286 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2071 5230951 39.92 µM -0.473510798880904 0.335539503292042 no 2253 0.317924399232821 3356 1799272
SGTC_658 3253-0951 102 µM -0.474545035640068 0.335162427279745 no 2254 0.317555645436771 3269 1184878
SGTC_1938 st074717 56.4 µM -0.474559397945284 0.335157192044582 no 2255 0.317550525876019 3272 17250979
SGTC_1222 0366-0074 1.18 µM -0.474910816416322 0.335029105711346 no 2256 0.317425270771933 3356 286520
SGTC_3005 9076496 71.4286 µM -0.479285126606688 0.333436350288712 no 2257 0.315867900850904 3328 21368410
SGTC_1272 0839-0021 27 µM -0.479525199497124 0.333349022493328 no 2258 0.315782522770582 3308 5027250
SGTC_2835 9006588 71.43 µM -0.481159271364641 0.332754860303392 no 2259 0.31520165258064 3390 2345538
SGTC_713 1488-1073 324 µM -0.481701085529619 0.332557944741451 no 2260 0.315009152413374 3322 3312542
SGTC_2302 7771753 200 µM -0.482401228547328 0.332303554964885 no 2261 0.314760474281476 3304 2203047
SGTC_1185 1319-0113 81.3 µM -0.48336750531651 0.331952595098684 no 2262 0.314417408200415 3341 4672763
SGTC_1637 st007924 17.4 µM -0.483389287305083 0.331944685394447 no 2263 0.314409676587125 3265 683336
SGTC_610 4215-0184 155 µM -0.483536835016471 0.331891108293435 no 2264 0.314357306017201 3317 5605015
SGTC_623 k072-0108 16.9 µM -0.483796267451541 0.331796912269325 no 2265 0.314265232155351 3307 5382803
SGTC_1097 itavastatin 7.23 µM -0.484923600406188 0.331387718140817 no 2266 0.313865270349033 3292 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_869 0564-0080 44.1 µM -0.485335842542736 0.331238134601277 no 2267 0.313719067223606 3290 6843321
SGTC_1107 amlodipine 47 µM -0.486578712098794 0.330787317952533 no 2268 0.313278456257489 3306 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_153 4077-0274 519.67 µM -0.487626687383903 0.33040738441134 no 2269 0.312907144437949 3487 3121976
SGTC_1371 2421-0008 32.7 µM -0.488486769667314 0.330095700235694 no 2270 0.312602547367949 3236 2827552
SGTC_2610 ononetin 44.17 µM -0.489323238239106 0.3297926864709 no 2271 0.312306435788229 3314 259632
SGTC_3353 9151644 39.2805 µM -0.490554792189425 0.329346754883044 no 2272 0.311870683766223 3367 4909158
SGTC_3240 9133527 49.47 µM -0.491676106341285 0.328940950854564 no 2273 0.311474165994679 3271 17617455
SGTC_1233 0325-0408 14.2 µM -0.492845076074101 0.328518114817208 no 2274 0.311061028998247 3365 12874
SGTC_2953 9074162 66.49 µM -0.492888277022816 0.328502492509334 no 2275 0.311045765486266 3341 16451992
SGTC_2305 7443522 69.23 µM -0.493378062865915 0.328325397342748 no 2276 0.310872739890103 3311 5415886
SGTC_365 0121-0052 13.6 µM -0.493392035631251 0.328320345681543 no 2277 0.310867804374407 3364 3101739
SGTC_876 0720-0963 56.8 µM -0.495555082818981 0.327538704754731 no 2278 0.310104175037201 3420 765861
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.495672171437203 0.327496415012512 no 2279 0.310062862083428 3295 688761
SGTC_3019 9081971 49.47 µM -0.497876160027791 0.326700797978941 no 2280 0.309285665732725 3435 16451803
SGTC_557 1315-0110 16.2 µM -0.4985173102061 0.326469497101437 no 2281 0.309059735741602 3283 6833801
SGTC_79 0052-0007 94.094 µM -0.498780871549599 0.326374434241702 no 2282 0.308966882318861 3416 2801472
SGTC_4 0960-0234 25.671 µM -0.498837426141108 0.326354037267409 no 2283 0.308946959563254 3350 6821112
SGTC_1710 st031758 61.5 µM -0.498969460207117 0.326306419893497 no 2284 0.308900449481148 3423 5394341
SGTC_93 0109-0045 59.227 µM -0.500411454876381 0.325786556728522 no 2285 0.308392694634285 3392 88733
SGTC_1684 st024538 14.6195 µM -0.500981195199514 0.325581249079097 no 2286 0.308192178696201 3292 6732859
SGTC_692 k241-0027 77.8 µM -0.501108660581487 0.325535323782667 no 2287 0.308147326019397 3429 3600480
SGTC_2677 mitomycin C 100 µM -0.502278285246908 0.325114036151512 no 2288 0.307735890862086 3336 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3263 9137018 49.47 µM -0.502336581982434 0.325093044066796 no 2289 0.30771539032295 3317 43844957
SGTC_3298 9116858 71.43 µM -0.502870696506823 0.324900740498335 no 2290 0.307527592395657 3390 2506942
SGTC_86 0417-1630 471.922 µM -0.504253458189261 0.324403105265026 no 2291 0.307041639341915 3374 3634867
SGTC_1088 bifonazole 369 nM -0.506019322515691 0.323768052888504 no 2292 0.306421542578149 3344 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2206 7254556 146.969 µM -0.506164983795424 0.323715692036118 no 2293 0.306370417212985 3314 4398905
SGTC_135 0933-0004 26.348 µM -0.506710877850437 0.323519490578131 no 2294 0.306178848475413 3385 21230617 YGL099W LSG1
SGTC_167 3672-0051 66.205 µM -0.507146386145027 0.323362998379965 no 2295 0.306026055029252 3292 3237971
SGTC_1826 st055655 41.6 µM -0.510396125843998 0.322196249935966 no 2296 0.304886985250556 3343 676168
SGTC_1936 st074407 74.3 µM -0.511395459535635 0.321837812128154 no 2297 0.304537086814705 3282 809813
SGTC_399 oxolinic acid 75 µM -0.512289414210062 0.321517311741927 no 2298 0.304224236397417 3299 4628 A DNA gyrase inhibitor.
SGTC_3038 9091290 49.47 µM -0.513364616632702 0.321132006406895 no 2299 0.30384814586941 3420 25236843
SGTC_1899 st063254 59.6 µM -0.514491719592059 0.320728308833743 no 2300 0.303454124078858 3266 3093813
SGTC_1424 4048-1941 275 µM -0.517137108339416 0.319781635689498 no 2301 0.302530225496855 3430 X1424
SGTC_1090 efavirenz 20.7 µM -0.518594593609758 0.319260563752575 no 2302 0.302021739999683 3364 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_3205 9113483 49.47 µM -0.518879352753006 0.319158799900109 no 2303 0.301922438452462 3428 17018033
SGTC_1916 st067606 49.2 µM -0.519800599489023 0.318829669020854 no 2304 0.301601280734373 3340 19590279
SGTC_180 1486-1293 102.781 µM -0.519996911684833 0.318759551642511 no 2305 0.301532863802543 3470 4140536
SGTC_3273 9137859 49.47 µM -0.521947259919116 0.318063293026837 no 2306 0.300853525926894 3416 2377234
SGTC_1279 0874-0590 65.2 µM -0.524328097555114 0.317214224113419 no 2307 0.300025178691879 3358 3523074
SGTC_3328 9140624 29.0385 µM -0.525034548820568 0.316962469850755 no 2308 0.299779586985774 3423 4904392
SGTC_3081 9117243 49.47 µM -0.527557027303532 0.316064239594795 no 2309 0.29890341283889 3452 45595589
SGTC_1028 k015-0029 4.8 µM -0.528065838151586 0.315883188249447 no 2310 0.298726820247238 3393 4588309
SGTC_3323 9138564 53.9225 µM -0.528231375843042 0.315824294106996 no 2311 0.298669377433901 3462 43912313 YNL103W MET4
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.53047944335356 0.315024951683143 no 2312 0.297889778981647 3348 688664
SGTC_1168 k815-0004 80.5 µM -0.531152604648264 0.314785764819984 no 2313 0.297656516676451 3308 642433
SGTC_3245 9134821 49.47 µM -0.532732627422438 0.314224658295824 no 2314 0.297109338513413 3338 17014901
SGTC_2884 9058502 51.95 µM -0.534221546605438 0.313696297583799 no 2315 0.296594131774591 3429 6471554
SGTC_2442 5158906 48.48 µM -0.534421960292467 0.313625207538197 no 2316 0.296524814422698 3416 1893835
SGTC_1137 ixabepilone 100 µM -0.535476880215612 0.313251124154307 no 2317 0.296160070278356 3434 154225 A novel microtubule stabilizer.
SGTC_1495 4469-0029 237 µM -0.537233611280463 0.312628599092426 no 2318 0.295553128474227 3418 793680
SGTC_155 k072-0202 43.6 µM -0.538286338951705 0.312255804450702 no 2319 0.295189690591627 3411 5857737
SGTC_2512 diallyl trisulfide 49.23 µM -0.538444105121395 0.312199952432168 no 2320 0.295135242004113 3417 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2065 5221596 34.26 µM -0.539040496837413 0.311988858203158 no 2321 0.29492945585558 3422 788581
SGTC_2181 6316240 54.2555 µM -0.539806739814598 0.311717735338183 no 2322 0.294665159283563 3396 12779990
SGTC_2855 9016525 58.44 µM -0.541088820078848 0.311264319884763 no 2323 0.29422318187849 3409 43811474
SGTC_2033 5192550 145 µM -0.542141654758226 0.310892192491236 no 2324 0.293860462525994 3344 182073
SGTC_2108 5365811 200 µM -0.542151371773265 0.310888758884563 no 2325 0.293857115813488 3425 780283
SGTC_2719 novobiocin 32.65 µM -0.542272644437302 0.31084590733323 no 2326 0.293815348837977 3466 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2614 arthonioic acid 13.39 µM -0.543147356115422 0.310536905009922 no 2327 0.293514174680576 3398 6710684
SGTC_933 2914-0560 114 µM -0.543923166477768 0.310262952569707 no 2328 0.293247173182038 3474 463887
SGTC_2623 humulene 100 µM -0.543928904353266 0.310260926815713 no 2329 0.293245198864634 3403 6187145 An anti-inflammatory.
SGTC_1807 st050092 58.9 µM -0.544344528974628 0.310114206071645 no 2330 0.293102205020843 3349 5008496
SGTC_2810 7959871 45.46 µM -0.54564025005021 0.309656994236513 no 2331 0.292656625513077 3383 2974535
SGTC_2240 6690706 185.951 µM -0.546880227771703 0.309219727768547 no 2332 0.292230510203484 3307 805876
SGTC_629 3448-6466 76.7 µM -0.547734124893549 0.308918765981543 no 2333 0.291937238471194 3440 573744
SGTC_1964 st076914 61 µM -0.548137591150735 0.308776606184242 no 2334 0.291798715319944 3434 24208661
SGTC_1014 4130-3005 69.3 µM -0.548336257413993 0.308706617408426 no 2335 0.291730517953366 3352 743608
SGTC_1987 st072290 61.9 µM -0.548755286929 0.308559018938935 no 2336 0.291586699525179 3365 54697379
SGTC_1957 st077035 62.4 µM -0.550972427445792 0.30777857115706 no 2337 0.290826287988548 3495 705593
SGTC_1050 3232-1156 69.3 µM -0.55120365074927 0.307697229035777 no 2338 0.290747038863116 3370 700529
SGTC_2472 5377652 49.4 µM -0.55132411333663 0.307654855207523 no 2339 0.290705755699388 3414 1610903
SGTC_1352 1496-0991 99 µM -0.551573718146715 0.307567062576074 no 2340 0.290620223541649 3387 3000039
SGTC_1608 st001473 40.5 µM -0.552855833657727 0.307116282324544 no 2341 0.29018106628021 3342 7292267
SGTC_1103 duloxetine 36.1 µM -0.553920614003188 0.306742136566505 no 2342 0.289816588358066 3496 60835 A selective serotonin reuptake inhibitor.
SGTC_2628 lathosterol 100 µM -0.554160114921511 0.306658007717388 no 2343 0.289734635977515 3490 6710616
SGTC_3082 9117008 49.47 µM -0.556183823210402 0.305947552086321 no 2344 0.289042598380486 3396 41448529
SGTC_2478 5763493 32.33 µM -0.556379324648946 0.305878956733218 no 2345 0.288975784917054 3402 1365576 YLR208W SEC13
SGTC_2785 7756463 72.73 µM -0.557310723944225 0.305552251312792 no 2346 0.288657574986089 3358 2201551
SGTC_2833 9001315 45.46 µM -0.558357495417393 0.305185261682614 no 2347 0.288300145569257 3315 2989378
SGTC_2338 7999974 200 µM -0.559820566754645 0.304672648770014 no 2348 0.287800916875985 3477 315925
SGTC_1016 4226-1401 38 µM -0.560104075619243 0.304573360728333 no 2349 0.287704225331782 3448 2901613
SGTC_703 3875-0075 71.8 µM -0.560698286784255 0.304365307908059 no 2350 0.287501617658003 3453 2850814
SGTC_3289 9119912 71.43 µM -0.561327737989471 0.304144985433072 no 2351 0.287287067833733 3488 17014829
SGTC_857 0438-0306 1.35 µM -0.561938150860167 0.303931394712728 no 2352 0.287079079656168 3484 4686136
SGTC_941 3237-0776 460 µM -0.562540748344573 0.30372060432322 no 2353 0.286873824409727 3491 760008
SGTC_971 1315-0384 26.7 µM -0.56625032537574 0.302424422987243 no 2354 0.285611811772903 3420 6769120
SGTC_73 0327-0325 16.231 µM -0.566686561166753 0.302272158863053 no 2355 0.285463576437489 3487 53298
SGTC_3158 9100007 49.47 µM -0.566844577293752 0.302217013262877 no 2356 0.28540989072211 3386 19297233
SGTC_1690 st023502 41.2 µM -0.568022176579945 0.301806188512865 no 2357 0.285009954835491 3482 24207482
SGTC_1940 st075990 51.1 µM -0.56831048466898 0.301705645788771 no 2358 0.284912080473393 3579 1084979
SGTC_374 0880-0231 82.3 µM -0.568478578662235 0.301647032712712 no 2359 0.284855023597057 3451 6833587
SGTC_481 bay k-8644 50 µM -0.56971968919811 0.301214425653697 no 2360 0.284433916847883 3418 2303 A calcium channel antagonist.
SGTC_578 3460-0051 92 µM -0.569865653141293 0.301163566178444 no 2361 0.284384411076873 3523 2876744
SGTC_822 1487-0950 154 µM -0.570017053494908 0.301110816536077 no 2362 0.284333065819684 3493 1958375
SGTC_591 4299-0174 154 µM -0.573124118634275 0.300029199754602 no 2363 0.283280328941053 3390 5509088
SGTC_2658 polymyxin b sulfate 77.05 µM -0.574681107644966 0.299487850076016 no 2364 0.282753493413354 3455 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2032 5185112 25.99 µM -0.57526271166437 0.299285745764666 no 2365 0.28255681795592 3389 5718189
SGTC_62 0180-0423 3.232 µM -0.575288130475619 0.299276914273901 no 2366 0.282548223820334 3446 30102 YGL099W LSG1
SGTC_36 0335-0881 14.2 µM -0.575751657407116 0.299115887599946 no 2367 0.282391526762312 3435 23828853
SGTC_2517 totarol 10 µM -0.576710332557964 0.298782974043585 no 2368 0.282067575641882 3434 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_301 4119-0100 24.5 µM -0.576831889006139 0.298740773873829 no 2369 0.28202651263016 3449 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2887 9044784 58.44 µM -0.576849867696642 0.298734532527978 no 2370 0.282020439488985 3483 6465546
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.577291796186026 0.298581134623884 no 2371 0.28187117733703 3563 6710655
SGTC_2552 juarezic acid 87.02 µM -0.57874895720228 0.298075593110469 no 2372 0.281379288405433 3527 1549512
SGTC_2094 5332512 191.667 µM -0.580060285709984 0.297620979838542 no 2373 0.280936982121643 3513 755774
SGTC_785 1270-0111 65.3 µM -0.580116326553166 0.297601558570274 no 2374 0.280918087241137 3486 6741994
SGTC_298 1391-0729 10 µM -0.580393029427148 0.297505674118824 no 2375 0.280824802365284 3448 3237558
SGTC_2685 mycophenolic acid 18.85 µM -0.583306043090642 0.296497099246098 no 2376 0.27984364757147 3428 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1441 4106-0040 13 µM -0.583410207839831 0.296461063240214 no 2377 0.279808593846358 3489 2904180
SGTC_690 glyoxal 20.3 µM -0.584330827866443 0.296142660182006 no 2378 0.279498877632908 3437 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_587 k089-0003 57 µM -0.585055607466663 0.295892100386411 no 2379 0.279255163492705 3471 9659696
SGTC_2750 bromebric acid 70.15 µM -0.585503260658381 0.295737393174823 no 2380 0.279104687393797 3509 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1560 lithocholic acid 53.1 µM -0.585561169465126 0.295717382830496 no 2381 0.2790852245548 3459 9903 A bile acid which acts as a detergent.
SGTC_845 0330-0138 4.51 µM -0.585636386790999 0.295691392469437 no 2382 0.279059945400793 3457 9039800
SGTC_2593 nobiletin 86.24 µM -0.588187969408743 0.294810349072115 no 2383 0.278203065802535 3427 72344 An anti-infammatory.
SGTC_1429 4049-0205 9.46 µM -0.590403153779464 0.294046444446302 no 2384 0.277460198360095 3521 22774478
SGTC_674 0498-0004 451 µM -0.591142621156686 0.29379164354473 no 2385 0.277212432220389 3457 4231473
SGTC_1105 epirubicin 18.1 µM -0.591402763256265 0.293702029753657 no 2386 0.277125294680791 3416 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_539 4859-0462 2.54 µM -0.591706983405034 0.293597248000026 no 2387 0.277023409704545 3517 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1847 st056231 15 µM -0.592600374304277 0.293289639786543 no 2388 0.276724314277125 3519 5393180
SGTC_1297 1068-0111 14.1 µM -0.593714333984485 0.292906295739475 no 2389 0.276351597121524 3446 767057
SGTC_1563 conessine 56.1 µM -0.595004875273116 0.292462476107755 no 2390 0.275920106073105 3556 441082 An anti-amoebic, histamine inhibitor.
SGTC_3187 9109394 49.47 µM -0.595485845632973 0.292297149472865 no 2391 0.275759378861954 3445 17098090
SGTC_2977 9011197 71.43 µM -0.595533226798611 0.292280865231724 no 2392 0.275743547855303 3553 2704722
SGTC_2513 baicalein 25.65 µM -0.595722460156664 0.292215832592881 no 2393 0.27568032561429 3460 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3189 9110682 49.47 µM -0.596211802617666 0.292047694564554 no 2394 0.275516870957541 3499 17122418
SGTC_911 3456-4043 236 µM -0.597264001055815 0.291686311883013 no 2395 0.275165567507405 3506 914281
SGTC_627 1391-0720 175 µM -0.598381951049111 0.291302575039001 no 2396 0.274792553041313 3455 997839
SGTC_981 1488-1094 54.9 µM -0.599277371823878 0.290995391488724 no 2397 0.274493967425796 3502 3449522
SGTC_2924 9010168 62.78 µM -0.600293789798522 0.290646882088281 no 2398 0.274155228390458 3509 2993929
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.60053790131994 0.290563210214819 no 2399 0.274073904726217 3494 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2300 7976697 71.57 µM -0.601501786338258 0.29023293832823 no 2400 0.27375291117681 3426 2236109
SGTC_3265 9137266 49.47 µM -0.601571279087685 0.290209133674688 no 2401 0.273729775849064 3476 17224265
SGTC_1314 1222-0010 41.1 µM -0.603372578151468 0.289592420339222 no 2402 0.273130430152792 3496 3526027
SGTC_15 0266-0086 27.098 µM -0.603879974049389 0.289418813614109 no 2403 0.272961721938175 3576 1712902 YIL048W NEO1
SGTC_2189 6047310 154.431 µM -0.604058974307234 0.289357579914367 no 2404 0.272902217009179 3494 711535
SGTC_170 4197-0004 226 µM -0.604498327298553 0.289207308685891 no 2405 0.272756190483461 3529 218692
SGTC_1786 berberine 21.6 µM -0.605064314017119 0.289013779208439 no 2406 0.272568132216036 3520 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_488 nitrendipine 139 µM -0.607952225577982 0.288027256958721 no 2407 0.271609580052525 3540 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_18 0111-0177 500 nM -0.608597754738702 0.28780695913416 no 2408 0.271395546538854 3591 721752
SGTC_1628 st004252 77.7 µM -0.60981399376111 0.287392113228037 no 2409 0.270992515274849 3521 692968
SGTC_3329 9141233 27.5565 µM -0.610514680227335 0.287153245180544 no 2410 0.270760460900726 3555 4909101 YNL103W MET4
SGTC_1981 st071826 47 µM -0.611252546002459 0.286901804141926 no 2411 0.270516200715582 3495 11838600
SGTC_3114 9122766 49.47 µM -0.611558572791305 0.28679755062182 no 2412 0.270414927119284 3483 17176985
SGTC_800 3448-7362 155 µM -0.611966237946298 0.286658700065776 no 2413 0.270280047728023 3592 15991913
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.613720516866198 0.286061557540476 no 2414 0.269700014110141 3477 803109
SGTC_1991 st073000 8.92 µM -0.614096640657161 0.285933604997682 no 2415 0.269575734007293 3610 4301969 YIL048W NEO1
SGTC_1557 sumaresinolic acid 42.3 µM -0.614458851888338 0.2858104110525 no 2416 0.269456078069222 3500 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1357 1503-1303 39.5 µM -0.615000956025203 0.285626079771085 no 2417 0.269277044531621 3539 292895
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.615292531327848 0.285526959031987 no 2418 0.269180774506281 3572 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2736 butenafine 14.65 µM -0.616261006356632 0.285197844462795 no 2419 0.268861135060976 3516 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2367 9070478 135.38 µM -0.617393319452067 0.284813282587321 no 2420 0.268487663684444 3526 572802
SGTC_509 pifithrin 175 µM -0.617702447921503 0.284708337831615 no 2421 0.268385749032314 3580 4817 A p53 inhibitor.
SGTC_26 0302-0163 425.158 µM -0.61873886632968 0.284356623143549 no 2422 0.268044200679366 3526 3100915
SGTC_2960 9079389 5.97 µM -0.619183456267547 0.2842058125962 no 2423 0.267897754589787 3545 16457355
SGTC_2596 sinensetin 100 µM -0.621720980021709 0.283345785183874 no 2424 0.267062676861041 3484 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.622186054993279 0.283188295586805 no 2425 0.266909767246212 3591 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2180 6301957 200 µM -0.622551126510633 0.283064699858649 no 2426 0.266789768246819 3540 845462
SGTC_2897 9048598 12.99 µM -0.622976791078722 0.282920622925887 no 2427 0.266649886748269 3506 6467404
SGTC_1827 berberine 7.24 µM -0.623709815736327 0.282672594765421 no 2428 0.266409087797351 3456 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2704 st078022 71.1 µM -0.626542746469582 0.281715020368484 no 2429 0.265479504071824 3588 54697681
SGTC_615 k087-0205 167 µM -0.628159873044887 0.281169108608827 no 2430 0.264949607043141 3520 9642773
SGTC_2096 5468907 200 µM -0.628768918214099 0.280963638848364 no 2431 0.264750175677833 3550 759785
SGTC_1879 gemcitabine 100 µM -0.629247069944827 0.280802378653088 no 2432 0.264593658769727 3546 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2426 5582046 32.21 µM -0.629671693516843 0.280659208753395 no 2433 0.264454703098646 3588 2251934
SGTC_647 0140-0236 81 µM -0.631060236332567 0.280191281876225 no 2434 0.264000569722143 3576 990837
SGTC_2187 6125751 200 µM -0.631273062483496 0.28011959473148 no 2435 0.263930998470172 3541 874498
SGTC_917 harmaline 728.087 nM -0.632273894935433 0.27978259927695 no 2436 0.263603959296089 3531 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1645 Cervolide 78 µM -0.633408273049988 0.279400874938811 no 2437 0.263233531931353 3532 23173 A fragrance.
SGTC_2838 9002687 71.43 µM -0.634125139885688 0.279159775913812 no 2438 0.262999578652137 3541 6457060
SGTC_2540 epiandrosterone 100 µM -0.634247146052855 0.279118752469664 no 2439 0.262959771880938 3649 441302 A steroid.
SGTC_641 4092-0595 30 µM -0.634587536558041 0.27900431481208 no 2440 0.262848729461474 3583 786260
SGTC_633 0437-0093 97.7 µM -0.634760516688806 0.278946168466883 no 2441 0.262792308957231 3574 2831118
SGTC_999 SEC7.066 22.7 µM -0.636832159205624 0.278250255353239 no 2442 0.262117088036979 3579 740511 YDR170C SEC7
SGTC_816 0325-0417 81.3 µM -0.637803104281164 0.277924383812282 no 2443 0.261800929286157 3556 68101
SGTC_1606 st000094 49.2 µM -0.637898293865631 0.277892446022924 no 2444 0.261769944223507 3615 1242210
SGTC_2315 7733312 200 µM -0.638381771945537 0.277730258237866 no 2445 0.261612596825379 3548 726316
SGTC_3029 9088683 49.47 µM -0.638751820449091 0.27760615283256 no 2446 0.261492197759478 3587 25236615
SGTC_1464 k208-0027 110 µM -0.638821289844994 0.277582857482055 no 2447 0.261469598352997 3606 X1464
SGTC_3152 9099253 49.47 µM -0.64127193375022 0.276761688501886 no 2448 0.260673010379053 3598 25236131
SGTC_1385 3091-4834 14.1 µM -0.644935099328575 0.275536447509065 no 2449 0.259484622389519 3557 4072814
SGTC_2589 lobaric acid 100 µM -0.644981054578846 0.275521093539974 no 2450 0.259469731581531 3552 73157 A novel microtubule depolymerizer.
SGTC_956 1185-0240 191 µM -0.647219264821321 0.274773801675594 no 2451 0.258745022386853 3586 1416193
SGTC_3258 9138477 49.47 µM -0.649062426793772 0.274159159407402 no 2452 0.258149013280701 3621 4970355
SGTC_525 k781-2675 26.7 µM -0.64941415944822 0.274041943751853 no 2453 0.258035357130307 3627 3651118 YDL195W SEC31
SGTC_411 enrofloxacin 100 µM -0.651123630356171 0.273472611835821 no 2454 0.25748334182674 3660 71188 A bacterial gyrase inhibitor.
SGTC_1158 4092-0494 91.8 µM -0.651229282819134 0.273437443960134 no 2455 0.257449245108717 3648 1148199
SGTC_175 3793-3120 23.7 µM -0.652400859253075 0.273047618769136 no 2456 0.257071305094373 3586 5322297
SGTC_1442 4112-3290 3 µM -0.652669638126975 0.272958225333867 no 2457 0.256984640160263 3586 704353
SGTC_215 1287-0124 461.5 µM -0.652746628136822 0.272932621823196 no 2458 0.256959818338295 3591 5560863
SGTC_1309 pyrazolanthrone 13.4 µM -0.653275158760507 0.272756887805215 no 2459 0.256789452077493 3625 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1172 0370-0043 85 µM -0.654437348718332 0.272370662504766 no 2460 0.256415039314489 3633 376585
SGTC_387 norethindrone acetate 66.7 µM -0.655147575211575 0.272134769977906 no 2461 0.2561863718577 3584 541197
SGTC_2389 9091542 195.52 µM -0.655281901020817 0.272090166824047 no 2462 0.256143135724991 3594 3626624 YOL127W RPL25
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.65616556620378 0.271796834665219 no 2463 0.255858800793529 3648 65057 A dermal irritant. YDR527W RBA50
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.657032908115562 0.271509074123665 no 2464 0.255579878442656 3624 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1364 1653-0028 37.6 µM -0.657391959113346 0.271389995159803 no 2465 0.255464460271296 3584 5718652
SGTC_884 0851-0618 334 µM -0.65782065005941 0.271247854256033 no 2466 0.255326691778169 3607 9642473
SGTC_248 streptozotocin 5.23457 mM -0.658066397615956 0.271166388564237 no 2467 0.255247733353713 3631 5300 DNA alkylating agent.
SGTC_2739 tacrine 100.86 µM -0.658167022226019 0.271133034872401 no 2468 0.255215406459395 3619 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2463 5473429 200 µM -0.658836393393521 0.270911212806142 no 2469 0.255000417231873 3544 5399405
SGTC_410 α-linolenic acid 100 µM -0.660900179845586 0.270227867755289 no 2470 0.25433816536518 3650 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1394 3474-0001 65.7 µM -0.66123757514593 0.270116234056211 no 2471 0.254229983832446 3544 5017666 YIL048W NEO1
SGTC_2914 7968218 45.32 µM -0.661625799952925 0.269987810991664 no 2472 0.254105534321894 3560 2977111
SGTC_2529 gangaleoidin 93.61 µM -0.661998624146133 0.269864511150137 no 2473 0.253986051723793 3656 4565183
SGTC_1548 st061468 90.8 µM -0.664512418828952 0.269033889377173 no 2474 0.253181201588922 3614 390799
SGTC_1486 3970-0793 4.53 µM -0.665393189307505 0.268743164238699 no 2475 0.252899519975929 3641 2844330
SGTC_109 0132-0036 33.701 µM -0.665424354277251 0.268732880182347 no 2476 0.252889556044162 3511 67274 A color developer.
SGTC_736 0958-0254 92.6 µM -0.667207741804591 0.268144713807673 no 2477 0.25231972335207 3664 6812352
SGTC_2241 6772625 37.8075 µM -0.667454090392205 0.268063518286194 no 2478 0.252241062645832 3574 2285411
SGTC_2797 7859098 81.82 µM -0.667462003749063 0.268060910280215 no 2479 0.252238536073897 3646 972681
SGTC_1370 2001-0092 44.6 µM -0.667626390504343 0.268006736206159 no 2480 0.252186053785227 3701 790957
SGTC_1152 3909-8331 15.9 µM -0.668824490807982 0.267612065765647 no 2481 0.25180372103054 3614 16001939
SGTC_1949 st076024 69.1 µM -0.669488684092225 0.26739339781535 no 2482 0.251591898376882 3609 2921930
SGTC_2587 piperic acid 92.2 µM -0.669504101063792 0.267388323258536 no 2483 0.251586982757771 3587 5370536
SGTC_825 1988-2224 89.6 µM -0.66951025041741 0.267386299188165 no 2484 0.25158502208334 3632 1180859
SGTC_3249 9135183 49.47 µM -0.670644506248856 0.267013089160123 no 2485 0.251223511379547 3659 4902779
SGTC_2733 amorolfine 100 µM -0.671614436947581 0.26669415666871 no 2486 0.250914592509556 3638 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2450 5739737 12.93 µM -0.672484317131814 0.266408286663458 no 2487 0.25063771041897 3629 2262825
SGTC_3176 9106582 49.47 µM -0.673374678107965 0.266115846661085 no 2488 0.25035447699821 3546 17018027
SGTC_1830 st055982 50.3 µM -0.674157762327669 0.26585877624879 no 2489 0.25010550977762 3594 455313 An antimicrobial agent.
SGTC_1311 1190-0148 100 µM -0.674163106736369 0.265857022222024 no 2490 0.250103811072558 3683 1961333
SGTC_2146 5545642 200 µM -0.67428785070808 0.265816083107223 no 2491 0.25006416329564 3656 825326
SGTC_927 2425-1185 123 µM -0.674490759476595 0.26574949829593 no 2492 0.249999679274407 3621 730375
SGTC_1864 st057645 30.4 µM -0.674641541590189 0.265700024399925 no 2493 0.249951766720348 3664 688666
SGTC_2997 9067075 71.4286 µM -0.674807710644761 0.26564550722499 no 2494 0.249898970453911 3628 27209819
SGTC_2644 guaiazulene 100 µM -0.676257641699212 0.265170050893282 no 2495 0.249438540605365 3649 3515 A coloring agent.
SGTC_2830 7992007 71.43 µM -0.676625497533118 0.265049493656466 no 2496 0.249321798652156 3579 1952075
SGTC_1881 5652484 16 µM -0.676958225442535 0.264940472867501 no 2497 0.249216229847249 3603 2255129
SGTC_2689 tacrolimus 100 µM -0.677640139892075 0.264717109729037 no 2498 0.24899994450295 3639 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_88 0180-0332 8.668 µM -0.677650407178486 0.264713747380257 no 2499 0.248996688752921 3687 3101745
SGTC_193 1273-0060 1.558 µM -0.678052185292862 0.264582189441312 no 2500 0.248869302955692 3530 2847393 YHR072W ERG7
SGTC_1518 st038567 90.8 µM -0.678957298191083 0.264285941835463 no 2501 0.248582459449794 3639 77966
SGTC_1458 k015-0034 6.33 µM -0.679280732276066 0.264180121350078 no 2502 0.248480001191103 3615 3598957
SGTC_7 0192-1582 4.227 µM -0.682065177295124 0.263270005981833 no 2503 0.247598869304981 3685 252616
SGTC_2322 7413319 38.22 µM -0.682087713827287 0.26326264629651 no 2504 0.247591744481351 3682 1840400
SGTC_1256 0570-0116 285 µM -0.682771689089304 0.263039332618902 no 2505 0.247375560878896 3645 410638
SGTC_1583 clindamycin 39.6 µM -0.682847286274031 0.263014656550095 no 2506 0.247351673120855 3574 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1156 4092-0367 4.88 µM -0.682899014083973 0.26299777248941 no 2507 0.24733532849509 3645 1357585
SGTC_3241 9133421 49.47 µM -0.683481669247181 0.262807630950474 no 2508 0.247151264690357 3660 17018221
SGTC_2999 9069765 71.4286 µM -0.684138904333831 0.262593235685757 no 2509 0.246943728657716 3662 2097066
SGTC_3148 9097893 49.47 µM -0.685393484532382 0.262184230384264 no 2510 0.246547827192965 3600 17174100
SGTC_2082 5219693 150 µM -0.686146727417508 0.261938822817994 no 2511 0.246310293645128 3662 2834649
SGTC_1047 2043-3044 82 µM -0.686264992096562 0.261900302723874 no 2512 0.246273010275195 3650 669592
SGTC_1118 chelidonine 707.474 nM -0.687941519250487 0.261354552216012 no 2513 0.24574480460985 3665 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2162 5663267 200 µM -0.688476206772172 0.261180621311977 no 2514 0.245576474288816 3648 6456493
SGTC_593 1203-0218 61.7 µM -0.689149957838327 0.260961538536478 no 2515 0.245364452206668 3688 3666956
SGTC_1625 st003711 30.1 µM -0.689401712144778 0.260879700168914 no 2516 0.245285253139976 3702 24207034 YER133W GLC7
SGTC_53 0973-0023 39.979 µM -0.689852767955089 0.260733107410263 no 2517 0.245143390441598 3634 674768
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.690246750522149 0.260605098097874 no 2518 0.245019514103998 3640 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_486 niguldipine 82 µM -0.691075542428174 0.260335920051114 no 2519 0.24475903460804 3667 1236 A calcium channel blocker.
SGTC_2446 5162541 200 µM -0.692178739527798 0.259977842041273 no 2520 0.244412544217023 3639 1549321
SGTC_96 0929-0093 37.281 µM -0.692589020470911 0.259844737025562 no 2521 0.244283751290142 3631 6991579
SGTC_530 4358-1714 28 µM -0.693712559734466 0.25948041389339 no 2522 0.243931243941549 3712 1564641
SGTC_3171 9103192 49.47 µM -0.696150256401512 0.25869086518354 no 2523 0.243167368003412 3704 13018434
SGTC_402 epigallocatechin gallate 10 µM -0.697046026072856 0.258401045971068 no 2524 0.242886995165584 3645 65064 An antioxidant.
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.699330062081332 0.257662826173337 no 2525 0.242172892015989 3715 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1284 0929-0043 16 µM -0.699517326070846 0.257602349470439 no 2526 0.242114394514479 3659 1239883
SGTC_3074 9116018 49.47 µM -0.700344813205715 0.25733520167321 no 2527 0.241855995938426 3719 17027303
SGTC_1737 st035557 69.7 µM -0.702298878668564 0.25670491873297 no 2528 0.241246396212871 3592 5716916
SGTC_2511 berberine 10.47 µM -0.703801915468569 0.256220662329525 no 2529 0.240778070340261 3681 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3204 9114183 49.47 µM -0.703850934368802 0.256204877182773 no 2530 0.240762805050755 3695 17027248
SGTC_1575 cyproterone acetate 48 µM -0.703871708792422 0.256198187521747 no 2531 0.240756335713413 3653 9880 An androgen receptor antagonist and liver toxin.
SGTC_2514 salinomycin 42.74 µM -0.704029893231586 0.256147252860829 no 2532 0.240707078797133 3743 23682228 A polyether potassium ionophore.
SGTC_2775 cyproheptadine 69.59 µM -0.704964677984513 0.25584636431777 no 2533 0.240416108983737 3683 2913 A selective serotonin reuptake inhibitor.
SGTC_264 promethazine 12.5 mM -0.705303204453377 0.255737444925657 no 2534 0.240310783351483 3717 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_428 3448-4153 16.5 µM -0.705582895877391 0.255647473715608 no 2535 0.24022378201721 3663 3834874
SGTC_2167 5876490 200 µM -0.707319631699015 0.25508917030182 no 2536 0.239683934148321 3791 686534
SGTC_3239 9133757 49.47 µM -0.708649721245672 0.254662021929646 no 2537 0.239270936529973 3688 17036923
SGTC_1285 0929-0069 65.5 µM -0.709145483542613 0.254502907435329 no 2538 0.239117100064115 3701 1206237
SGTC_2842 9000675 19.48 µM -0.711544619251296 0.253733643403153 no 2539 0.238373405712981 3668 2989072
SGTC_2008 4012253 172 µM -0.711709870732927 0.253680701793772 no 2540 0.238322227022544 3714 603940
SGTC_3234 9132280 49.47 µM -0.712500182277607 0.253427589957467 no 2541 0.238077549307042 3700 17612295
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.713508494308497 0.253104852239091 no 2542 0.237765579376112 3707 3256 An antibiotic and ribosome inhibitor.
SGTC_2136 5328288 199.296 µM -0.715148736829624 0.252580310222924 no 2543 0.23725857070055 3705 262395
SGTC_310 1273-0058 1.06 µM -0.715898277414129 0.252340801371784 no 2544 0.237027081094187 3694 2734232
SGTC_2134 5324836 1.464 µM -0.716563670493278 0.252128281448877 no 2545 0.236821683822131 3687 699272
SGTC_2486 5283202 22.39 µM -0.718156461707744 0.25161994353185 no 2546 0.236330409869651 3719 1377751
SGTC_1559 coumarin 343 70.1 µM -0.719388637480241 0.251227067436798 no 2547 0.235950747918867 3709 108770 A hepatotoxic, DNA x-linker.
SGTC_2484 5809818 12.04 µM -0.719419440874196 0.251217250011204 no 2548 0.235941260987004 3707 2870548
SGTC_2234 tolnaftate 200 µM -0.720298899192808 0.250937041289879 no 2549 0.235670491187968 3701 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1614 st002383 48.6 µM -0.721308511629077 0.250615567557351 no 2550 0.235359860637546 3700 1947235
SGTC_1283 0922-0125 16.4 µM -0.72208708353336 0.250367809201808 no 2551 0.235120469457919 3721 3360884
SGTC_553 k007-0256 45.7 µM -0.725138147802288 0.249398147508157 no 2552 0.234183641718555 3764 6287000
SGTC_2017 5132927 60.65 µM -0.726231340040068 0.249051205380342 no 2553 0.233848481184555 3732 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2216 7189485 200 µM -0.727109993545027 0.248772536813371 no 2554 0.233579288627155 3708 731273
SGTC_2680 butyl paraben 22.24 µM -0.727223093178952 0.248736678864345 no 2555 0.23354465084618 3763 7184 An antifungal and steroid mimetic.
SGTC_2350 9023895 38.85 µM -0.727530766272402 0.248639145827838 no 2556 0.233450437608378 3735 2997209
SGTC_2980 9014342 25.29 µM -0.727930694454251 0.248512398183136 no 2557 0.233328006261245 3727 2996599
SGTC_1030 k029-0042 36.7 µM -0.728276363063237 0.24840287455239 no 2558 0.233222214290173 3726 6080581
SGTC_2122 5258151 111.688 µM -0.729488449721483 0.248019033399363 no 2559 0.232851465276297 3728 2173356
SGTC_441 propafenone 146 µM -0.731110333285908 0.24750591404595 no 2560 0.232355881575229 3697 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_3035 9091303 49.47 µM -0.731213525780509 0.247473285982255 no 2561 0.232324369881493 3763 25237002
SGTC_1545 lovastatin 49.4 µM -0.731451017296318 0.247398203126773 no 2562 0.232251856586814 3787 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1184 1269-1718 139 µM -0.731819955640775 0.247281587557188 no 2563 0.232139233608687 3751 5403821
SGTC_186 3455-3465 67.277 µM -0.732147872474768 0.247177962911597 no 2564 0.23203915847299 3677 755278
SGTC_1460 k062-0059 9.15 µM -0.732322839774439 0.247122681186553 no 2565 0.231985770993325 3645 1373085
SGTC_2272 7805186 180 µM -0.732782653928637 0.246977432316166 no 2566 0.23184550127979 3691 2956062 YPR165W RHO1
SGTC_1817 st052116 64.4 µM -0.733363171432523 0.246794120205767 no 2567 0.231668477607311 3727 4361398
SGTC_2139 5578692 56.4705 µM -0.733930249390843 0.246615122303423 no 2568 0.231495624956931 3666 650991 YMR113W FOL3
SGTC_786 4544-0069 423 µM -0.735081331362015 0.246251997734309 no 2569 0.231144981579988 3781 748821 YLR208W SEC13
SGTC_573 3702-0553 84.7 µM -0.73559026833128 0.246091538039985 no 2570 0.230990043389093 3694 1222756
SGTC_1218 1348-1416 30.7 µM -0.736096129982284 0.245932103537178 no 2571 0.230836098901086 3700 6787668
SGTC_2386 9075165 157.42 µM -0.736746234367903 0.245727288874812 no 2572 0.230638342431279 3702 16452277
SGTC_1262 0737-0114 49.6 µM -0.737106289487893 0.245613893330678 no 2573 0.230528857334515 3755 765919
SGTC_1651 st011928 86.1 µM -0.738448961749112 0.245191280865823 no 2574 0.230120835515055 3732 720198
SGTC_584 0986-0246 15.4 µM -0.738579675762119 0.245150158905978 no 2575 0.230081134704801 3827 53315 YDR232W HEM1
SGTC_2427 5545055 42.75 µM -0.738603562405322 0.24514264469104 no 2576 0.2300738802037 3728 5372858
SGTC_257 daunorubicin 18.5 µM -0.738629826574576 0.245134382701435 no 2577 0.230065903782971 3778 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2217 6934799 96.0675 µM -0.738942227609037 0.245036121361808 no 2578 0.229971039544827 3678 675606
SGTC_948 3448-0295 75.3 µM -0.739582295597465 0.244834863199014 no 2579 0.229776743788373 3749 678569
SGTC_1695 st026914 34.495 µM -0.741424813969015 0.244256012609178 no 2580 0.229217951827656 3704 3289191
SGTC_1824 st053723 68.6 µM -0.742474280263288 0.243926639494305 no 2581 0.228900014619806 3722 675225
SGTC_3115 9123671 49.47 µM -0.743760660455359 0.243523238503124 no 2582 0.228510641855063 3822 3286988
SGTC_2850 9015429 58.44 µM -0.743803567534453 0.243509789317592 no 2583 0.228497660782026 3798 6457570
SGTC_770 0389-1121 67.2 µM -0.743908100141797 0.243477025344892 no 2584 0.22846603730557 3843 6753108
SGTC_918 glabranin 770.725 nM -0.744564432454666 0.243271363543108 no 2585 0.228267538142485 3775 124049 Also referred to as licorice root.
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.744664599666026 0.243239984397387 no 2586 0.228237252402293 3782 1377
SGTC_765 1319-0117 244 µM -0.744811444902994 0.243193986492022 no 2587 0.228192857558677 3711 3487746 YGL099W LSG1
SGTC_1485 3909-9022 254 µM -0.745282887990124 0.243046343117341 no 2588 0.228050361803452 3775 714516
SGTC_2994 9053520 71.4286 µM -0.745649244820375 0.242931643432046 no 2589 0.227939663397409 3765 4647384
SGTC_1321 1326-2144 215 µM -0.746070028253718 0.2427999399059 no 2590 0.227812556752723 3748 3513030
SGTC_391 gliotoxin 8.33 µM -0.746340395448244 0.242715336454958 no 2591 0.22773090760582 3829 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1175 0741-0056 27.6 µM -0.750334867217907 0.241467245723791 no 2592 0.226526523986715 3817 765927
SGTC_2790 5423970 71.43 µM -0.751253453774549 0.241180722991949 no 2593 0.22625006799318 3799 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_309 k408-0051 1.48 µM -0.751874630984863 0.240987072069897 no 2594 0.226063227811326 3731 3640463
SGTC_732 3970-1727 52.7 µM -0.752683428989481 0.240735057471723 no 2595 0.225820085045113 3768 1275699
SGTC_1812 st052057 4.327 µM -0.752946452862283 0.240653132379924 no 2596 0.225741046069178 3770 3645418
SGTC_1005 4092-0690 4.4 µM -0.753728437746535 0.240409654093273 no 2597 0.225506151161374 3787 1529343
SGTC_1930 st074634 34.3 µM -0.754170673585463 0.240272019259545 no 2598 0.225373372331724 3697 684253 YOR116C RPO31
SGTC_2726 cimetidine 79.27 µM -0.754628315627388 0.240129634847178 no 2599 0.225236014493974 3749 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2333 9017922 200 µM -0.754741771630728 0.240094342832111 no 2600 0.225201968858821 3795 3163164
SGTC_2507 purpurin 79.67 µM -0.755618596706487 0.239821689996602 no 2601 0.224938951400161 3776 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2957 9076800 11.52 µM -0.755933621329929 0.239723772885704 no 2602 0.22484449734694 3736 16459615
SGTC_2321 7390090 138.78 µM -0.756301422041061 0.239609479326631 no 2603 0.224734247860439 3767 649046
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.757572447256394 0.239214739107292 no 2604 0.224353489942767 3788 521171
SGTC_1510 1123-0200 71.5 µM -0.76009735207938 0.238431638715163 no 2605 0.223598197663813 3803 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_143 4032-1194 15.74 µM -0.760185614983423 0.238404289350173 no 2606 0.223571821153961 3791 1806963
SGTC_2903 5923464 63.88 µM -0.760946592375088 0.238168562253061 no 2607 0.223344483879289 3795 2876576
SGTC_2699 st077704 54.6 µM -0.761456604623463 0.238010647848614 no 2608 0.223192194538787 3800 645852
SGTC_447 ml7 120 µM -0.761561641043514 0.237978132692314 no 2609 0.223160838071396 3793 4216 Selective myosin light chain kinase inhibitor.
SGTC_2406 ethylparaben 405.7 µM -0.764132702461428 0.237182992704002 no 2610 0.222394082902998 3817 8434 A possible steroid mimic.
SGTC_2537 larixol 68.93 µM -0.764259101241733 0.237143939627236 no 2611 0.222356426401929 3777 6708759
SGTC_2117 5521686 200 µM -0.767836787993239 0.236040018216774 no 2612 0.221292077819342 3750 803312
SGTC_2979 9012552 45.46 µM -0.767938630313277 0.23600863552653 no 2613 0.221261822820104 3823 17100905
SGTC_1487 3970-0795 2.82 µM -0.76799552226402 0.235991105284468 no 2614 0.221244922566643 3847 3765103
SGTC_821 1114-0266 29.2 µM -0.770141295978247 0.23533044747577 no 2615 0.220608040976389 3802 3123235
SGTC_613 3914-0030 117 µM -0.771177116815765 0.235011896499911 no 2616 0.220300977922565 3542 1145395
SGTC_581 0958-0271 211 µM -0.771352912449725 0.234957856877549 no 2617 0.220248888664176 3806 4591145
SGTC_101 0490-5701 117.494 µM -0.772284912631178 0.234671474510826 no 2618 0.219972849640829 3654 4661669
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.772726373049301 0.234535891204899 no 2619 0.21984216758188 3793 689007
SGTC_2195 6536160 144.242 µM -0.773048811030104 0.234436889993197 no 2620 0.21974674696545 3718 3834386
SGTC_1025 k007-0731 70 µM -0.773335892682052 0.234348764034583 no 2621 0.219661809529673 3769 6256118
SGTC_589 1227-0070 34.1 µM -0.773543359665517 0.23428508894422 no 2622 0.219600439030538 3818 2841384
SGTC_2543 pimpinellin 60.67 µM -0.773805941154059 0.234204512022038 no 2623 0.219522779312025 3693 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2889 9059656 51.95 µM -0.773887427410762 0.234179509907038 no 2624 0.21949868257356 3878 3949838
SGTC_1915 st067105 30.6 µM -0.775927331025916 0.233554095900008 no 2625 0.218895947042081 3780 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_3275 9138069 49.47 µM -0.77614145961766 0.23348849998128 no 2626 0.218832733186865 3899 17617007
SGTC_1975 st070967 30.8 µM -0.77662196223772 0.233341340534133 no 2627 0.21869092010528 3761 261391
SGTC_2020 4017018 200 µM -0.777672106678518 0.233019900954227 no 2628 0.218381170053285 3882 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2508 celastrol 40.54 µM -0.779606481864543 0.232428450619373 no 2629 0.217811269725411 3752 122724 Celastrol is a natural product and antioxidant.
SGTC_528 3492-0019 172 µM -0.780067562504851 0.232287594938518 no 2630 0.217675554124667 3811 2869262
SGTC_1286 0929-0070 131 µM -0.781179929235285 0.231947973229978 no 2631 0.217348338307562 3888 1420408
SGTC_1725 st036284 20.55 µM -0.784575684403329 0.230912912316385 no 2632 0.216351195595487 3884 707914
SGTC_1809 st050081 57.6 µM -0.785811987603827 0.230536715813174 no 2633 0.215988821287309 3857 5036894
SGTC_1259 0671-0132 43 µM -0.785824875244889 0.230532796018867 no 2634 0.21598504562823 3767 X1259
SGTC_3102 9121669 49.47 µM -0.787283889318177 0.230089275700715 no 2635 0.215557849284403 3818 41905072
SGTC_1892 st058411 7.36 µM -0.787394689840012 0.230055613374157 no 2636 0.215525427149287 3801 3934738
SGTC_1399 3562-5772 25 µM -0.788492833407424 0.2297221352209 no 2637 0.215204244446399 3760 23847490
SGTC_159 3970-0959 50 µM -0.789897531700901 0.229295959132314 no 2638 0.214793806505293 3891 6615653
SGTC_724 3910-0327 137 µM -0.79103675279423 0.228950652823447 no 2639 0.214461272425181 3856 2885483
SGTC_2287 7945887 168.79 µM -0.794501327213637 0.227902309892233 no 2640 0.213451818306683 3855 1245853
SGTC_2834 9001755 58.44 µM -0.794727912273761 0.227833841910754 no 2641 0.213385896078598 3777 2989575
SGTC_2197 6588183 93.1375 µM -0.795601661632129 0.227569926488317 no 2642 0.213131800244592 3766 884136
SGTC_883 0850-0245 24.6 µM -0.797090058588116 0.227120753791891 no 2643 0.212699364814828 3920 6823229 YPR165W RHO1
SGTC_1835 st008666 49.2 µM -0.797730318030212 0.226927688307163 no 2644 0.212513503007011 3758 690455
SGTC_1868 st057644 42.7 µM -0.802091998656922 0.225614921685115 no 2645 0.211249871532008 3842 688665
SGTC_510 ag-490 170 µM -0.802413749139982 0.225518252600655 no 2646 0.211156831209342 3944 5328779
SGTC_2499 avocadenofuran 51.48 µM -0.803200296509508 0.225282035247699 no 2647 0.21092948708209 3833 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1246 0422-0085 105 µM -0.803541490673783 0.225179610780182 no 2648 0.210830912762165 3854 264295
SGTC_2299 7976368 114.88 µM -0.803560125589855 0.225174017448554 no 2649 0.210825529731451 3897 2979718
SGTC_3120 9124077 49.47 µM -0.803704499260308 0.225130685881382 no 2650 0.21078382753117 3887 18774327 YGL155W CDC43
SGTC_1072 oxiconazole 14.9 nM -0.804665614242025 0.224842342233081 no 2651 0.210506333700741 3827 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1709 st033179 39.1045 µM -0.804889323000195 0.224775257526518 no 2652 0.210441775116253 3808 573381
SGTC_2939 9044578 71.43 µM -0.805337569435717 0.224640873701336 no 2653 0.210312453714311 3802 2653634
SGTC_401 neomycin 50 µM -0.806878490120009 0.224179255021789 no 2654 0.209868246248772 3823 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_423 5-fluorouracil 457 µM -0.809050027096861 0.223529635946918 no 2655 0.209243185553744 3820 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3356 9151811 4.48 µM -0.813083904698435 0.222325740857167 no 2656 0.208084976931172 3833 1859254 YPR165W RHO1
SGTC_1405 3909-7894 12 µM -0.813919672824259 0.222076772504022 no 2657 0.207845484912831 3875 7104060
SGTC_802 4112-3352 742 µM -0.814575279354653 0.221881584225645 no 2658 0.207657732753371 3952 704594
SGTC_2789 5281112 71.43 µM -0.814830840835546 0.221805524580134 no 2659 0.207584572379178 3874 765948
SGTC_721 1187-1332 279 µM -0.816950446866589 0.221175266382493 no 2660 0.20697837347991 3790 25730
SGTC_967 1306-0166 352 µM -0.817553032396634 0.22099627668473 no 2661 0.206806227838195 3804 4437607
SGTC_748 act1.228 77.9 µM -0.817572566094776 0.220990475857501 no 2662 0.206800648902149 3805 4421505 YNR035C ARC35
SGTC_1479 0549-0158 134 µM -0.817661541469192 0.220964054376359 no 2663 0.206775238152911 3892 5440202
SGTC_45 0kpi-0036 14.9 µM -0.819191100991536 0.220510130293597 no 2664 0.20633869567209 3877 2795021
SGTC_3047 9092122 49.47 µM -0.823613935755656 0.219200585765574 no 2665 0.205079477546729 3849 17173831
SGTC_271 rotenone 740 µM -0.825609297937029 0.218611251220338 no 2666 0.204512879516009 3864 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_121 0557-0495 61.343 µM -0.825628257683806 0.218605655796322 no 2667 0.20450750022585 4016 3104427
SGTC_2465 5809242 33.21 µM -0.825722131289168 0.218577952916053 no 2668 0.204480867494615 3889 2731748
SGTC_3030 9087619 49.47 µM -0.827801079534251 0.217964956266972 no 2669 0.203891581616856 3909 25236973
SGTC_552 k242-0005 476 µM -0.82830553056003 0.217816363908254 no 2670 0.203748745764434 3941 4088318
SGTC_1788 fluconazole 20 µM -0.829772032774187 0.217384719319937 no 2671 0.203333843001638 3918 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1659 st012954 42.1 µM -0.829804772036863 0.217375088611498 no 2672 0.203324586167342 3877 24207262
SGTC_265 mycophenolic acid 32.932 µM -0.830077307477962 0.217294928091345 no 2673 0.20324753813178 3938 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2753 fluvastatin 17.09 µM -0.830136287973932 0.217277582476621 no 2674 0.203230866149021 3925 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_3121 9125696 49.47 µM -0.830379855283513 0.217205960069092 no 2675 0.203162025764092 3947 1235365
SGTC_1462 k081-0014 26.5 µM -0.830773534677095 0.217090225155683 no 2676 0.203050788047995 3570 3270634
SGTC_95 0471-0001 561.058 µM -0.831074102093919 0.217001887540524 no 2677 0.202965884460556 3848 4015405
SGTC_70 0141-0289 43.283 µM -0.831387721822267 0.216909735964812 no 2678 0.202877316493482 3903 352408
SGTC_1653 st012112 65 µM -0.832250812354672 0.216656248992052 no 2679 0.202633694114208 3857 720429
SGTC_1119 parthenolide 318.541 nM -0.832291237368494 0.216644380494805 no 2680 0.20262228773607 4014 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_3108 9121785 49.47 µM -0.833932632789266 0.216162796170252 no 2681 0.202159473521269 3747 17140271
SGTC_650 1328-0195 38 µM -0.8355290858822 0.215694993151443 no 2682 0.201709938725271 3804 2780821
SGTC_2624 nerol 100 µM -0.835743363667566 0.215632248793834 no 2683 0.201649647248187 3794 637566 A natural product oil.
SGTC_2067 5224629 34.075 µM -0.8363662775676 0.215449908604708 no 2684 0.201474438880622 3879 2835000
SGTC_1114 scopoletin 1.73284 µM -0.836607646356522 0.21537927886048 no 2685 0.201406573078595 3876 5280460 A coumarin with genotoxic properties.
SGTC_1714 st033236 13.627 µM -0.836757397258362 0.215335465251233 no 2686 0.201364474418871 3891 2916566
SGTC_688 0527-0193 473 µM -0.837546718620237 0.215104613777732 no 2687 0.20114266396281 3899 4007154
SGTC_3290 9121031 71.43 µM -0.837653611598318 0.21507336202075 no 2688 0.201112636794643 3885 17014854
SGTC_1927 st060202 13.8 µM -0.837700306141386 0.215059711001763 no 2689 0.201099520734688 3793 688887
SGTC_3007 9078383 71.4286 µM -0.837760943590451 0.215041984564085 no 2690 0.201082489008683 3877 6496995
SGTC_2584 androsterone 48.74 µM -0.838624073238158 0.214789753716084 no 2691 0.20084014868708 3878 2754130 A steroid.
SGTC_448 monastrol 171 µM -0.839249053400501 0.214607224210554 no 2692 0.200664782884574 3798 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1512 0259-0544 12.2 µM -0.841027848937539 0.214088209198031 no 2693 0.200166166581076 3842 18476
SGTC_1317 1273-0028 910 nM -0.841331068826955 0.213999808962054 no 2694 0.200081244998342 3882 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1130 3454-2858 15.9 µM -0.843236878408803 0.213444678977078 no 2695 0.199547988549179 3941 715628 YIL048W NEO1
SGTC_2813 7971799 71.43 µM -0.846079098623583 0.212618349649087 no 2696 0.198754309941513 3966 2234054
SGTC_1036 k216-0215 33.5 µM -0.846105170086459 0.21261077845249 no 2697 0.198747038410543 3888 622330
SGTC_27 0485-0001 32.618 µM -0.847062875717505 0.212332768269051 no 2698 0.198480038143564 3826 2054479
SGTC_1339 1486-1321 22.7 µM -0.848688235169275 0.211861432912761 no 2699 0.198027397183544 3915 3469382
SGTC_1771 st048882 4.1505 µM -0.849773928979796 0.211546935603315 no 2700 0.197725393487447 3916 4580403
SGTC_2725 haloperidol 53.21 µM -0.851973939186165 0.210910488526783 no 2701 0.197114278300217 3861 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2622 2-methoxyxanthone 59.94 µM -0.852712273085918 0.210697145741551 no 2702 0.196909441567456 3923 71034 A hepatoprotective.
SGTC_1154 4088-0362 150 µM -0.852849290705695 0.210657568208303 no 2703 0.196871442809848 3899 6618304
SGTC_2194 5927483 104.545 µM -0.854474779403668 0.210188378772927 no 2704 0.196420988888415 3906 760979
SGTC_1992 st073643 23.3 µM -0.85527065974087 0.209958875782553 no 2705 0.196200663251286 3858 3161292
SGTC_1448 4255-0083 152 µM -0.856292279511678 0.209664493681202 no 2706 0.195918065319812 3984 5399660
SGTC_323 4013-0906 34.3 µM -0.857357573340015 0.20935778546159 no 2707 0.19562364956153 3938 2910086
SGTC_881 0833-0569 170 µM -0.857523010824923 0.209310178134271 no 2708 0.195577951634887 3923 5418700
SGTC_943 3253-1379 105 µM -0.861120240541298 0.208276593153219 no 2709 0.194585911264349 3890 668464
SGTC_1602 st001878 87.6 µM -0.863156154665577 0.207692954715874 no 2710 0.19402580838235 3929 595405 YLR310C CDC25
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.863618891125972 0.207560436271517 no 2711 0.193898641513851 3938 368090
SGTC_325 2810-4341 181 µM -0.864026422955554 0.207443768717933 no 2712 0.19378668777806 3927 774970
SGTC_2396 5342950 42.78 µM -0.86506327280979 0.207147115843444 no 2713 0.193502030772098 3927 1886677
SGTC_738 1315-0003 72.4 µM -0.868069093180502 0.20628854065964 no 2714 0.192678254721356 3958 6251474
SGTC_1344 1488-0097 29.1 µM -0.868683814350495 0.206113213340911 no 2715 0.192510048385894 3960 747966
SGTC_353 1988-1175 58.3 µM -0.869645720289785 0.205839041299803 no 2716 0.192247021979765 3771 2788357
SGTC_1984 st072354 53.1 µM -0.87000461891058 0.205736799883274 no 2717 0.192148940014639 3824 5762938
SGTC_621 3584-0052 32.1 µM -0.870074756300247 0.205716822981636 no 2718 0.192129776025243 3911 2273927
SGTC_3126 9127922 49.47 µM -0.870198239031025 0.205681654775927 no 2719 0.192096039063671 3971 45595682
SGTC_3154 9100113 49.47 µM -0.871441583113233 0.205327746013275 no 2720 0.191756544592515 3969 25237525
SGTC_2756 carbadox 75.1 µM -0.871888347932302 0.205200666080568 no 2721 0.191634645464515 3938 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2107 5363541 170.161 µM -0.873391122133235 0.204773552868534 no 2722 0.191224964165893 3910 244052
SGTC_1092 toremifene 6.32 µM -0.876932518321982 0.203769123174022 no 2723 0.19026164617043 3936 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_651 3253-0966 34.4 µM -0.877588179003111 0.203583483929988 no 2724 0.190083623304246 3973 781462
SGTC_260 nsc-65238 3.989 µM -0.879523622489717 0.20303608441999 no 2725 0.189558715326331 3917 3246252
SGTC_2696 st077691 74.316 µM -0.87967815053139 0.20299241733073 no 2726 0.189516844547285 3988 757133
SGTC_1546 5-methoxyflavanone 78.7 µM -0.880272592700839 0.202824490018268 no 2727 0.189355828091179 3927 147795
SGTC_493 zm226600 134 µM -0.880371820520088 0.202796466678604 no 2728 0.189328958471083 3983 5240098 A potassium channel opener. YCR052W RSC6
SGTC_279 1273-0055 2.93 µM -0.880427832056623 0.202780649249909 no 2729 0.189313792302156 3947 2847562
SGTC_830 4076-0286 57.8 µM -0.880903553170658 0.202646337272466 no 2730 0.18918501208334 4012 6866659
SGTC_160 3453-0671 289.699 µM -0.881652135083732 0.202435095257623 no 2731 0.18898247625996 4003 5322268
SGTC_1165 k072-0275 30.3 µM -0.881799766571852 0.202393450739448 no 2732 0.188942548957424 3924 6153523 YGL055W OLE1
SGTC_2105 5350118 200 µM -0.882570642034654 0.202176082138868 no 2733 0.188734148203484 3945 2133313
SGTC_2342 7990637 118.86 µM -0.883659517659996 0.2018692831272 no 2734 0.188440019852443 4019 2033102 YER133W GLC7
SGTC_2930 9013230 14.89 µM -0.887089560828945 0.200904665894604 no 2735 0.187515341962977 3990 2995857
SGTC_1340 1486-1359 257 µM -0.888082958640381 0.200625813951005 no 2736 0.187248064321619 3894 4309068
SGTC_1664 st014217 9.02 µM -0.888424790053961 0.200529913855514 no 2737 0.187156147719621 3984 3982782
SGTC_3355 9151058 44.0485 µM -0.888439556815277 0.200525771691574 no 2738 0.187152177646943 3932 17015728
SGTC_132 0417-1715 25.805 µM -0.888737663299175 0.200442162047808 no 2739 0.187072042274651 3897 6769098
SGTC_2592 piperlongumine 83.33 µM -0.888977395986773 0.200374939640181 no 2740 0.187007614030339 3977 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1375 2910-0797 186 µM -0.890513904906776 0.199944415468944 no 2741 0.186595002736755 3986 742508
SGTC_346 4513-0042 7.16 µM -0.890748563073928 0.199878714105502 no 2742 0.186532037717885 3942 2827372
SGTC_3348 9149464 3.537 µM -0.891147340729871 0.199767091115154 no 2743 0.186425065265473 3935 1951442
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.892317408378399 0.199439790640825 no 2744 0.186111412984593 4017 5393153
SGTC_2981 9013952 38.96 µM -0.894904163661103 0.198717349898167 no 2745 0.185419160414381 3943 2996344
SGTC_3196 9111891 49.47 µM -0.895262011739138 0.198617532856669 no 2746 0.185323521180502 3954 18891510
SGTC_1696 st025591 34.7925 µM -0.896063540737367 0.198394066572081 no 2747 0.185109414005274 3960 2787147
SGTC_3000 9075062 71.4286 µM -0.898318517057101 0.197766193468359 no 2748 0.184507881662024 3929 17057871
SGTC_668 1682-0499 62.6 µM -0.899026020650238 0.197569444682805 no 2749 0.184319400465726 3973 682214
SGTC_1870 st057514 26.5 µM -0.900138368390029 0.197260352663604 no 2750 0.184023309851631 3943 5393161
SGTC_2468 5987765 72.9 µM -0.900170089797349 0.197251542415618 no 2751 0.184014870424664 4013 26772094
SGTC_1437 4092-1038 11.6 µM -0.900197999169648 0.197243791112404 no 2752 0.184007445382473 3990 3977136
SGTC_115 0527-0192 112.043 µM -0.900226403258381 0.197235902600208 no 2753 0.183999888916874 3987 4233931
SGTC_2732 terfenadine 20 µM -0.90031832476298 0.197210375051861 no 2754 0.183975435956091 3976 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2665 lovastatin 100 µM -0.903309453544438 0.196380798979625 no 2755 0.183180840308506 4007 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1989 st071868 50.2 µM -0.904882474660929 0.19594537862073 no 2756 0.182763826214783 3969 16414057
SGTC_1386 3228-0095 33.8 µM -0.906899531976017 0.195387904620488 no 2757 0.182229964344828 4015 870181
SGTC_1958 st076513 41.9 µM -0.907509221066671 0.195219588648127 no 2758 0.182068787735932 3955 732122 YGL099W LSG1
SGTC_1572 epiandrosterone 68.9 µM -0.908085601964763 0.195060549068955 no 2759 0.181916498418208 3875 441302 A steroid.
SGTC_1002 4049-0206 172 µM -0.908412077354305 0.194970500347061 no 2760 0.181830273599358 3990 4662749
SGTC_648 0375-0473 33.3 µM -0.910587013142346 0.194371252995037 no 2761 0.181256507889693 3960 1713139
SGTC_171 k064-0041 9.68 µM -0.911429797043495 0.19413934743749 no 2762 0.181034479804265 3997 53325
SGTC_1134 3477-0009 42.5 µM -0.913856905644571 0.193472431614745 no 2763 0.180396020182555 4099 3973534
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.913859588755933 0.193471695129229 no 2764 0.180395315163117 4005 23665772 A membrane-active detergent.
SGTC_2363 9053361 176 µM -0.917003264584189 0.192609964820261 no 2765 0.179570464717553 4065 6469797 YMR079W SEC14
SGTC_961 1252-1571 372 µM -0.91885197082192 0.192104302917465 no 2766 0.179086502311053 4003 6813498
SGTC_806 3966-4455 5.86 µM -0.919199069211457 0.19200945450534 no 2767 0.17899572895601 3970 714982
SGTC_2276 7947513 42.08 µM -0.919525581037292 0.191920257760739 no 2768 0.178910365841614 3957 2105100
SGTC_64 000l-0018 272.079 µM -0.919944457055054 0.191805866044213 no 2769 0.17880089259581 3936 6811119
SGTC_1588 farnesol 29.9 µM -0.921311127750037 0.191432929508764 no 2770 0.178444006525369 3995 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1146 3579-1023 7 µM -0.922317916146628 0.191158481934266 no 2771 0.178181385718668 4039 X1146
SGTC_1746 st038117 42 µM -0.923025394369518 0.190965769837694 no 2772 0.177996985809109 4067 2898218
SGTC_1768 st044301 37.178 µM -0.923636852685557 0.190799308929787 no 2773 0.177837709885196 3999 3931349
SGTC_2223 6903751 107.57 µM -0.923700730628347 0.190781924198184 no 2774 0.177821075805793 3958 5598863
SGTC_1380 2291-0730 164 µM -0.924524323616194 0.190557865925697 no 2775 0.177606696705951 4042 2999191
SGTC_532 1548-0774 215 µM -0.924616617740592 0.19053276740158 no 2776 0.177582682953838 4136 5932993
SGTC_2975 9084847 53.72 µM -0.925213270093398 0.190370562348936 no 2777 0.177427491078295 4073 27211724
SGTC_3214 9129694 49.47 µM -0.925418957933341 0.190314664011975 no 2778 0.177374010627012 4037 17158655
SGTC_965 1291-5240 308 µM -0.927564524169317 0.189732179831409 no 2779 0.176816753510745 4026 2834598
SGTC_482 fipronil 114 µM -0.928000062077883 0.18961407282665 no 2780 0.176703768708918 4070 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2274 7947094 46.08 µM -0.928760784165599 0.189407892510933 no 2781 0.176506535968259 3955 2971028
SGTC_1873 rapamycin 2 nM -0.929969244205417 0.189080644543591 no 2782 0.176193504436044 3977 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2339 9000433 200 µM -0.930760142292937 0.188866659960649 no 2783 0.175988825752633 4030 2988954
SGTC_1123 mangostin 811.285 nM -0.931835865647588 0.188575852956199 no 2784 0.175710678105745 4029 5281650 An antioxidant.
SGTC_1712 st032288 53.4 µM -0.932361491489155 0.188433857706219 no 2785 0.17557486942667 3932 2883011
SGTC_2709 st078560 56 µM -0.932635549755111 0.188359848368179 no 2786 0.175504085959835 3987 17250903
SGTC_1865 st057639 52.2 µM -0.933056502354829 0.188246205195406 no 2787 0.175395398018871 3991 688818
SGTC_2201 6605497 169.863 µM -0.933525370435708 0.188119676253114 no 2788 0.175274388775875 3928 670741
SGTC_1605 st000082 49.1 µM -0.935791803724641 0.187508795968205 no 2789 0.174690196166535 3997 1114022
SGTC_952 1185-0122 232 µM -0.935993195649371 0.187454573415411 no 2790 0.174638345542764 3950 678600
SGTC_794 k038-0031 316 µM -0.936187148252156 0.18740236297958 no 2791 0.174588419494529 4006 6624242
SGTC_2662 daunorubicin 22.37 µM -0.940823576250462 0.186156951872046 no 2792 0.173397638435014 3918 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_491 tetrandrine 80.3 µM -0.940946792201644 0.186123924425826 no 2793 0.173366063376596 4033 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_489 paxilline 115 µM -0.941763888895804 0.185904997478666 no 2794 0.173156768538676 4013 105008 A toxic potassium channel blocker.
SGTC_2534 helenine 20.12 µM -0.942249075448791 0.185775075715914 no 2795 0.173032566843052 4013 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2570 licareol 100 µM -0.943534553993354 0.185431126596889 no 2796 0.172703774850858 4028 443158
SGTC_1033 k072-0102 21.3 µM -0.944106985338409 0.185278091267944 no 2797 0.172557490044554 4011 5965931
SGTC_1247 0448-0043 5.84 µM -0.944133462590993 0.185271014666475 no 2798 0.172550725696142 4059 3089013 YGL099W LSG1
SGTC_3161 9100388 49.47 µM -0.944360023804988 0.185210468289581 no 2799 0.172492851265224 4081 25236368
SGTC_928 2764-0428 58.7 µM -0.945032078525768 0.185030940216097 no 2800 0.172321249595528 4060 662578
SGTC_2265 7929201 200 µM -0.945295289308628 0.184960657372115 no 2801 0.172254071351958 3990 1265108
SGTC_2419 paclitaxel 166.5 µM -0.946370718222593 0.184673667499737 no 2802 0.171979767544925 3965 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2673 kobusone 100 µM -0.947418760835382 0.184394252494063 no 2803 0.171712717476423 4091 6710676 An epoxy ketone and protein crosslinker.
SGTC_2056 5235370 200 µM -0.949207286091428 0.183918027748964 no 2804 0.171257598287604 3990 5511916
SGTC_484 loperamide 105 µM -0.949427912404196 0.183859335420064 no 2805 0.171201509838536 3998 3955 An opioid-receptor agonist.
SGTC_2715 st079500 56.4 µM -0.950534146853379 0.183565224246192 no 2806 0.170920455894524 3979 28246688
SGTC_507 nimesulide 162 µM -0.950576134077991 0.183554067009654 no 2807 0.170909794285738 4093 4495 A COX2 inhibitor.
SGTC_320 4092-0846 5.34 µM -0.951779682397823 0.183234428645546 no 2808 0.170604364120641 4002 1359356
SGTC_1304 1165-0502 251 µM -0.953158738805475 0.18286860588377 no 2809 0.170254824316999 4039 767425
SGTC_1020 4335-0961 93.3 µM -0.953723209324569 0.182719000166354 no 2810 0.170111884343343 3963 669075
SGTC_2258 7960471 200 µM -0.955428995901653 0.182267367717172 no 2811 0.169680398238914 4065 2974708
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.957861133539689 0.181624630611774 no 2812 0.169066393656072 4033 5106787 A p450 inhibitor.
SGTC_3311 9131146 2.8755 µM -0.958222481592243 0.181529258902842 no 2813 0.168975291539073 4027 4900406 YPR165W RHO1
SGTC_293 4049-0273 38.5 µM -0.958850975738182 0.181363453187232 no 2814 0.168816912387952 3910 1380311
SGTC_1780 st038448 24.544 µM -0.95927018354343 0.181252912925653 no 2815 0.168711325983135 4106 728868 YDL195W SEC31
SGTC_2224 6650123 117.647 µM -0.961423358911509 0.180685810579269 no 2816 0.168169671973922 4006 2908370
SGTC_2417 cerulenin 830 nM -0.961974908972354 0.180540722760159 no 2817 0.16803110393504 4079 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1955 wogonin 32.4 µM -0.961976801083301 0.180540225157339 no 2818 0.16803062869925 4130 5281703 A flavanone.
SGTC_2279 7948423 32.93 µM -0.962742915282505 0.180338816866045 no 2819 0.167838277192909 3968 1247112
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.96578141079562 0.179541398020082 no 2820 0.16707678611549 4057 688669
SGTC_2566 crystal violet carbinol 226 nM -0.967111983494908 0.179192903040604 no 2821 0.166744027755061 4122 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_342 k048-0088 23.3 µM -0.967582477203461 0.1790697762676 no 2822 0.166626466005787 4036 6820570
SGTC_1438 4092-1045 4 µM -0.967698467101848 0.179039430244229 no 2823 0.166597491957881 4041 1351342
SGTC_416 estradiol valerate 100 µM -0.967943546623012 0.178975321605128 no 2824 0.166536282271571 4079 13791 A steroid.
SGTC_1683 st010134 710 nM -0.968359336850588 0.178866590992004 no 2825 0.166432470047261 4044 3818134
SGTC_1401 3807-4679 7.6 µM -0.970394180165085 0.178335072084309 no 2826 0.16592502424786 3985 3291456
SGTC_1439 4092-1168 46 µM -0.971569478332959 0.178028527802603 no 2827 0.165632386420184 4071 2886240
SGTC_2893 9048488 25.97 µM -0.971952331706037 0.177928742786112 no 2828 0.165537131762141 4097 6467338
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.97197889707859 0.177921820227183 no 2829 0.165530523561012 4044 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2449 5812982 45.77 µM -0.972335021264295 0.177829035721616 no 2830 0.165441953277913 3994 776185
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.974699775667969 0.177213697641839 no 2831 0.164854602134284 4099 6708561
SGTC_235 0330-0087 5 mM -0.977407572466962 0.176510749419794 no 2832 0.164183707793733 4086 46494818 YHR062C RPP1
SGTC_2441 5730946 39.09 µM -0.977790199195363 0.176411561336642 no 2833 0.164089049680692 4122 1774275
SGTC_1707 st032323 6.317 µM -0.978191336080189 0.176307612746573 no 2834 0.163989850354343 3945 3132057 YMR211W DML1
SGTC_1648 st011736 69.8 µM -0.979626051195126 0.175936145195832 no 2835 0.16363537035314 4078 2855514
SGTC_1774 st048371 48.465 µM -0.97982168514171 0.175885531291902 no 2836 0.163587072972343 4045 4242727
SGTC_3094 9117742 49.47 µM -0.980509334816603 0.175707697546682 no 2837 0.163417382034915 3994 17149698
SGTC_929 2805-0021 398 µM -0.980981131230799 0.175585751735398 no 2838 0.163301023245815 4130 3098024
SGTC_2774 tamoxifen 10.92 µM -0.984633672474481 0.174643490414222 no 2839 0.162402021758624 4066 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2873 9040596 71.43 µM -0.986560134228648 0.174147808733761 no 2840 0.161929160914944 4070 6463863
SGTC_2481 5478948 45.16 µM -0.9876011398792 0.17388032884456 no 2841 0.161674013909697 4121 77792
SGTC_2876 9059903 25.97 µM -0.988611926067557 0.173620863796245 no 2842 0.161426524469089 4041 6916095
SGTC_595 3909-8003 73.7 µM -0.989252343621052 0.173456598552743 no 2843 0.161269847138124 4141 699517
SGTC_2323 6148992 148.28 µM -0.989297449920672 0.173445032647987 no 2844 0.161258815680516 4047 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3284 9108171 64.8615 µM -0.989730626653601 0.17333398489004 no 2845 0.161152900535526 4060 8687505
SGTC_2722 naftopidil 47.16 µM -0.989932374685 0.173282280884069 no 2846 0.161103587038526 3984 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2885 9057732 51.95 µM -0.991749716201392 0.172816975141801 no 2847 0.160659816118882 4159 6471414
SGTC_1482 3346-2049 8.48 µM -0.99176210656109 0.172813805493179 no 2848 0.160656793298492 4080 3826804
SGTC_228 caffeine 993.056 µM -0.995209382185216 0.171933377628995 no 2849 0.159817219800732 4086 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_3180 9109287 49.47 µM -0.995437076830025 0.171875325837813 no 2850 0.159761866695721 4120 18891271
SGTC_1970 st070122 35.8 µM -0.995640862215317 0.171823380436802 no 2851 0.15971233662601 4118 102928
SGTC_1615 st002656 86.5 µM -0.996230527962551 0.171673129657719 no 2852 0.159569074878605 4079 1584458
SGTC_1126 isoteolin 1.0172 µM -0.996875619241375 0.171508852250415 no 2853 0.159412443634853 4031 133323
SGTC_2987 9018338 71.43 µM -0.999726285616812 0.170784111661115 no 2854 0.158721493863239 4123 5055682
SGTC_2203 7227154 166.4 µM -1.00024372356659 0.170652771038099 no 2855 0.158596287150139 4070 896304
SGTC_1305 1181-0477 144 µM -1.00095228691831 0.170473022220489 no 2856 0.158424938091488 4155 6252086
SGTC_314 1671-0008 2.74 µM -1.00253315516813 0.17007242371611 no 2857 0.158043080887235 3969 3913060
SGTC_2459 5811157 9.22 µM -1.00382688067876 0.169745037642957 no 2858 0.157731032669181 4063 2870684 YBR192W RIM2
SGTC_1597 7-benzyloxygramine 47.5 µM -1.00603220073243 0.169187898721012 no 2859 0.157200040271416 4029 260807
SGTC_479 n-linoleoylglycine 10 µM -1.00952641863404 0.168307547168789 no 2860 0.156361119089226 4131 6433346 An anti-infammatory.
SGTC_1717 st033143 58.0435 µM -1.00996332670965 0.168197677867031 no 2861 0.156256430310916 4177 674616
SGTC_1452 4194-0072 190 µM -1.01105441677712 0.167923502924477 no 2862 0.155995192821351 4169 1343545
SGTC_1236 0330-0013 258 µM -1.01274399945053 0.167499503573528 no 2863 0.155591227795489 4122 4617066
SGTC_1241 0364-0022 50.8 µM -1.0129091554056 0.167458094862612 no 2864 0.155551777448672 4125 4563895
SGTC_3281 9140613 49.47 µM -1.01416316657736 0.167143898225403 no 2865 0.155252450537711 4111 16013766
SGTC_142 0335-0849 62.6745 µM -1.01750544445499 0.166308337240642 no 2866 0.154456521792057 4106 3889043 YPR107C YTH1
SGTC_3321 9137793 26.8275 µM -1.01770572614316 0.166258353138719 no 2867 0.154408912606349 4077 4904192
SGTC_2242 6630449 61.2675 µM -1.0186931823415 0.166012056539236 no 2868 0.15417432513191 4172 691249 YDR170C SEC7
SGTC_2436 5633522 8.09 µM -1.01957321006309 0.165792754117601 no 2869 0.153965457932386 4097 5724242
SGTC_366 0181-0206 4.31 µM -1.01992156192462 0.165705996789229 no 2870 0.153882831290735 4136 274874
SGTC_1703 st026983 48.3 µM -1.02153506203383 0.165304536147055 no 2871 0.153500503088808 4134 1104023
SGTC_418 lividomycin a 100 µM -1.02212891387698 0.165156936364591 no 2872 0.15335994497459 4137 72394 An antibiotic.
SGTC_1310 1188-0297 994 nM -1.0230441879051 0.164929615345501 no 2873 0.153143476841339 3991 1588352
SGTC_2868 9035608 32.47 µM -1.02367267150657 0.164773640101616 no 2874 0.152994953791213 4088 6462614
SGTC_1804 st050076 49.1 µM -1.02860550443001 0.163552743393533 no 2875 0.151832545159421 4149 3895976
SGTC_1109 tnp00067 928.257 nM -1.02864526189738 0.163542927178923 no 2876 0.151823200321854 4107 676295
SGTC_2585 alliin 100 µM -1.02931122518138 0.163378556116849 no 2877 0.151666725064901 4190 87310 A garlic compound which reacts with lipids.
SGTC_753 1322-0200 289 µM -1.02985245329099 0.163245050891083 no 2878 0.151539636663282 4198 5403907
SGTC_474 dl-dihydrosphingosine 5 µM -1.0315951583903 0.162815657981924 no 2879 0.151130904725433 4144 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1966 st070145 16.1 µM -1.0318366043947 0.162756225003643 no 2880 0.151074334177185 4090 3748532
SGTC_1978 st071761 42 µM -1.03320276815081 0.162420203719066 no 2881 0.150754508869376 4139 5147680
SGTC_792 4534-1957 155 µM -1.03339359365121 0.162373304291271 no 2882 0.150709871637707 4056 1717904
SGTC_2787 5284540 71.43 µM -1.0338264013724 0.162266965254302 no 2883 0.150608663393168 4177 736958
SGTC_2222 6885208 172.143 µM -1.03797932277213 0.161248915215631 no 2884 0.149639840844505 4084 609514
SGTC_2102 5377816 72.7585 µM -1.0417036862625 0.160339473726866 no 2885 0.148774539710927 4181 1379702
SGTC_3256 9138902 49.47 µM -1.04261590938524 0.160117232669124 no 2886 0.148563108952838 4203 17228773
SGTC_3310 9130229 44.1445 µM -1.04565892727509 0.15937733226556 no 2887 0.147859266138371 4178 7761258
SGTC_2452 5863136 48.41 µM -1.04984280289525 0.158363696575724 no 2888 0.146895196165177 4096 2184096
SGTC_678 1218-2179 85.9 µM -1.05030679343984 0.158251545782617 no 2889 0.146788541402518 4140 6820081 YOR116C RPO31
SGTC_133 0724-0033 378.92 µM -1.05222380365715 0.157788739354401 no 2890 0.146348440426379 3976 280309
SGTC_3003 9075612 71.4286 µM -1.05430735412727 0.157286735785048 no 2891 0.145871111430947 4171 6501993
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.05784725430223 0.156436254284736 no 2892 0.145062542690725 4193 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_282 k297-0036 65.7 µM -1.05961632174023 0.156012362608251 no 2893 0.144659592564263 4154 5061378
SGTC_664 1222-0054 14.9 µM -1.05998196540291 0.155924844099859 no 2894 0.144576402026292 4129 6813991
SGTC_1277 0873-0036 22 µM -1.06213679676761 0.1554097326794 no 2895 0.144086793702392 4235 5965735
SGTC_2767 sibutramine 71.45 µM -1.0621539757111 0.155405630577866 no 2896 0.144082894899816 4186 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_924 2046-0044 21.3 µM -1.0624236012124 0.15534125698149 no 2897 0.144021712063605 4142 3623589
SGTC_1969 st069479 40.1 µM -1.06292016846269 0.155222746669962 no 2898 0.143909077950996 4153 3895485
SGTC_1354 1498-1681 81 µM -1.06339491593627 0.155109499665966 no 2899 0.143801448693954 4168 5754243
SGTC_3104 9120930 49.47 µM -1.06386421940081 0.154997604913223 no 2900 0.143695107031161 4182 17014836
SGTC_1238 0333-0287 48.8 µM -1.0661022662123 0.154464726892466 no 2901 0.14318870765122 4129 7226
SGTC_3141 9094609 49.47 µM -1.06761959818245 0.15410414046004 no 2902 0.142846069771761 4120 25236309 YDL196W YDL196W
SGTC_2249 haloperidol 116.36 µM -1.06874300230598 0.153837528077075 no 2903 0.142592744434723 4138 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_728 3030-5151 22.5 µM -1.06888411893562 0.15380405910648 no 2904 0.142560944413338 4219 3125388
SGTC_2801 7907800 81.82 µM -1.07010434231092 0.153514856824895 no 2905 0.1422861723931 4181 6620925
SGTC_675 1309-0189 238 µM -1.0717254776181 0.153131192772117 no 2906 0.141921676931492 4189 4246530
SGTC_3247 9135149 49.47 µM -1.07297068800771 0.152836928445131 no 2907 0.141642133952047 4182 8934436 YOR116C RPO31
SGTC_2470 5664817 21.68 µM -1.07376459368314 0.152649510959099 no 2908 0.14146410128039 4193 2859561
SGTC_2404 5161160 200 µM -1.07421254344143 0.152543830671046 no 2909 0.141363715875726 4123 2831543
SGTC_743 1275-0778 158 µM -1.0745391920672 0.152466798355027 no 2910 0.141290544465857 4151 2849257 YMR203W TOM40
SGTC_1435 4092-0789 56.7 µM -1.07553678388798 0.15223169986444 no 2911 0.141067236388492 4162 2248285
SGTC_652 0437-0092 114 µM -1.07797365735622 0.151658424141591 no 2912 0.140522756103143 4103 3091274
SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.07997180199543 0.151189431608112 no 2913 0.140077368568744 4223 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_207 4185-0010 4.486 µM -1.08020354998638 0.15113509961682 no 2914 0.14002577395364 4226 3761753
SGTC_2388 9080168 200 µM -1.08027839899693 0.151117554469984 no 2915 0.140009112896692 4158 15943073
SGTC_1295 1013-0063 9.78 µM -1.08082494045732 0.150989482294414 no 2916 0.139887496027907 4193 6826038
SGTC_317 4495-0002 170 µM -1.08204949795215 0.150702791547254 no 2917 0.139615267176816 4198 15991618
SGTC_2938 9059746 27.26 µM -1.08220955120886 0.150665347027522 no 2918 0.139579712705375 4180 6471769
SGTC_1022 4477-0945 21.3 µM -1.08351684175327 0.150359737892582 no 2919 0.139289539757975 4129 4648966
SGTC_1264 0783-0040 158 µM -1.08430883328729 0.150174792770726 no 2920 0.139113945030658 4056 2855798
SGTC_2400 5203494 178.7 µM -1.0849259667862 0.150030785487906 no 2921 0.138977223069146 4088 6777674
SGTC_905 2-aminofluorene 215 µM -1.08741409711524 0.149451117756381 no 2922 0.138426921916 4188 1539 An established DNA mutagen. YPR165W RHO1
SGTC_415 dibenzyl ketone 100 µM -1.08845079844357 0.149210035890694 no 2923 0.138198072979213 4166 7593
SGTC_662 k832-1615 104 µM -1.09469937449899 0.147762449889667 no 2924 0.136824181374536 4210 5878478
SGTC_1844 rapamycin 4 nM -1.0951440214136 0.147659799709301 no 2925 0.136726772704345 4083 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2190 6049624 200 µM -1.0963778289483 0.147375215880766 no 2926 0.136456731190919 4070 2265554
SGTC_179 1273-0063 6.77 µM -1.09832474289368 0.146926898570947 no 2927 0.136031355659334 4150 3108139
SGTC_1035 k081-0041 55.2 µM -1.09987153078349 0.146571371276807 no 2928 0.135694050222425 4226 731709
SGTC_1173 0443-0020 122 µM -1.10043823997764 0.146441258508453 no 2929 0.135570612424241 4178 5331295
SGTC_409 arachidonic acid 100 µM -1.10231735823945 0.146010380054302 no 2930 0.135161862757835 4179 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_406 estrone 100 µM -1.10487072997756 0.145426262840531 no 2931 0.13460780350595 4191 5870 A steroid.
SGTC_1647 st011722 22.4 µM -1.106036218676 0.145160165200819 no 2932 0.134355421572495 4170 2854783
SGTC_1093 fluphenazine 7.97 µM -1.10633657974126 0.145091641634857 no 2933 0.134290432275509 4208 6602611 An atypical antipsychotic.
SGTC_2683 piperine 63.03 µM -1.10686575365986 0.144970970292406 no 2934 0.134175987139713 4172 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2679 rapamycin 1 nM -1.10698192331412 0.14494448833555 no 2935 0.134150871947408 4113 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1914 st062367 72.6 µM -1.10843724282678 0.144613010626197 no 2936 0.133836514099998 4194 978205
SGTC_1219 1469-0211 33.1 µM -1.11192284156707 0.143821174431742 no 2937 0.133085663396661 4230 6822282
SGTC_2383 9036125 200 µM -1.11386067691559 0.143382216822335 no 2938 0.132669480716206 4126 79580
SGTC_862 0452-0056 10.2 µM -1.11451696622538 0.143233759734956 no 2939 0.132528735001727 4161 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1235 benzylparaben 21.5 µM -1.11614567252965 0.142865783985457 no 2940 0.132179892401561 4232 7180
SGTC_2423 st077119 87.2 µM -1.11617810728929 0.14285846245231 no 2941 0.132172951834636 4131 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_755 1995-0008 37.3 µM -1.11662704562708 0.142757149166275 no 2942 0.132076911365273 4176 689533
SGTC_906 1165-0455 526 µM -1.1175313078369 0.142553229028592 no 2943 0.131883610491762 4187 3252859
SGTC_1613 st002381 52.1 µM -1.11839258566743 0.142359185548066 no 2944 0.131699679773919 4186 551167
SGTC_92 0063-0024 660.874 µM -1.11869636384089 0.142290787824371 no 2945 0.131634848485081 4297 3594437
SGTC_2231 micatex 6.853 µM -1.11924883633629 0.142166451879736 no 2946 0.131516998172683 4226 20737 An antifungal of unknown mechanism.
SGTC_922 1866-0035 480 µM -1.12078224221549 0.141821738655572 no 2947 0.131190282368444 4138 3156169
SGTC_281 1672-3440 14.9 µM -1.13093299860977 0.139554105578894 no 2948 0.129041646525623 4267 6833000
SGTC_988 1497-1057 103 µM -1.13154879266978 0.139417337782034 no 2949 0.128912089507491 4206 3533044
SGTC_804 1595-0054 20.9 µM -1.13194676674132 0.139328996303265 no 2950 0.12882840768273 4166 761523 Stimulates phospholipase C.
SGTC_2103 5378138 10 µM -1.13224073445061 0.139263766407427 no 2951 0.128766619429655 4284 244142
SGTC_540 1187-0821 17.3 µM -1.13421846330894 0.138825458937174 no 2952 0.128351460555893 4163 847520
SGTC_1934 st074720 32.6 µM -1.13578698854247 0.138478508513656 no 2953 0.128022861932069 4174 17250992
SGTC_2306 7482397 179.52 µM -1.13871340941787 0.13783277868433 no 2954 0.127411353970357 4243 891448
SGTC_2700 st077718 96.8 µM -1.13908224576485 0.137751539062659 no 2955 0.127334425934994 4224 904970
SGTC_1626 st003712 1.76 µM -1.13919677006901 0.137726320673034 no 2956 0.127310546225539 4271 24207035
SGTC_2799 7812892 81.82 µM -1.14201214012058 0.137107363400338 no 2957 0.126724486741114 4263 20205235
SGTC_2837 9008476 45.46 µM -1.14281984384113 0.136930141617532 no 2958 0.126556699016833 4243 2992805
SGTC_1195 1502-0147 41.1 µM -1.14491213571611 0.136471791027451 no 2959 0.12612277816136 4218 817940
SGTC_1434 4073-0095 163 µM -1.14667058638172 0.136087386279863 no 2960 0.125758895672656 4211 24133745
SGTC_165 k038-0023 64.381 µM -1.1492081389866 0.135533974086385 no 2961 0.125235082795451 4236 46368543
SGTC_1051 3253-3903 78 µM -1.14982272804946 0.13540017128932 no 2962 0.125108446082435 4222 5509239
SGTC_1748 st037455 53.6035 µM -1.15053363725098 0.135245511498692 no 2963 0.124962074091569 4289 580690
SGTC_1494 4358-1428 177 µM -1.15165666347236 0.135001441635839 no 2964 0.124731093482136 4264 1564571
SGTC_3140 9094243 49.47 µM -1.15566965180964 0.134131759068651 no 2965 0.123908153055667 4222 19291112
SGTC_2686 alizarin 95.37 µM -1.15584312678727 0.134094251082932 no 2966 0.12387266456564 4232 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1345 1488-0192 31.4 µM -1.15626819014347 0.134002376241979 no 2967 0.123785737681091 4297 658348
SGTC_1904 st060225 78 µM -1.15745841673471 0.133745346216195 no 2968 0.123542559576366 4191 66595
SGTC_521 r062-0005 13.8 µM -1.1590458707824 0.133403062488513 no 2969 0.123218743958738 4167 2832033
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.15942893723038 0.133320556779378 no 2970 0.12314069359892 4236 641818 YHR062C RPP1
SGTC_2408 sulbentine 18.36 µM -1.16020127520771 0.133154315659656 no 2971 0.12298343396106 4158 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_3044 9093193 49.47 µM -1.16222258443278 0.132719916404107 no 2972 0.122572531582389 4282 25236277
SGTC_1446 4239-0190 62 µM -1.16268243920066 0.132621225531187 no 2973 0.122479184532537 4267 1340085
SGTC_1044 1222-0021 1.78 µM -1.16414189370735 0.132308342308428 no 2974 0.122183256709655 4198 4306703
SGTC_561 1550-0330 72.9 µM -1.1664153207068 0.131821970931482 no 2975 0.121723283572135 4198 6812934
SGTC_194 1486-1323 56.904 µM -1.17123354167592 0.130795253748096 no 2976 0.120752458217406 4345 5178754
SGTC_136 0097-0015 404.482 µM -1.17438310412329 0.130127106879175 no 2977 0.120120804860709 4266 4861337
SGTC_1854 st056233 32.9 µM -1.17639641479652 0.129701243572616 no 2978 0.119718251872834 4204 5393174
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.17819094509071 0.129322471989347 no 2979 0.119360245815454 4289 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2268 7933382 153.85 µM -1.17854365659692 0.129248115394797 no 2980 0.11928996933516 4290 935025 YOR257W CDC31
SGTC_1726 st035556 14.5795 µM -1.17904606663443 0.12914225140146 no 2981 0.119189916399545 4342 5919439
SGTC_2858 9025781 8.96 µM -1.18487872319946 0.127917637875884 no 2982 0.118032700485532 4156 4894980 YPL153C RAD53
SGTC_331 k048-0133 24.5 µM -1.18493129214254 0.127906637414217 no 2983 0.118022306918731 4221 6813582
SGTC_1669 st015249 58.4 µM -1.18629334933455 0.127621845450276 no 2984 0.117753236079545 4357 722793
SGTC_1351 1496-0003 46.5 µM -1.1896101615124 0.126930179346056 no 2985 0.117099825048254 4293 3891978
SGTC_384 k007-0144 5.16 µM -1.19024567373007 0.126797952262482 no 2986 0.116974923156276 4201 6824886
SGTC_1736 st036774 51 µM -1.19166526193668 0.126502933823336 no 2987 0.11669626211095 4329 1272247
SGTC_1052 3253-3998 198 µM -1.19525956622407 0.125758105620144 no 2988 0.115992816080768 4217 5450317
SGTC_2173 5763948 167 µM -1.19627177270307 0.125548904721395 no 2989 0.115795260181871 4261 2867177
SGTC_706 4262-0057 46.9 µM -1.19733123862768 0.125330196584558 no 2990 0.115588736563517 4274 883298
SGTC_3296 9122258 64.045 µM -1.19870850582191 0.125046281766625 no 2991 0.115320654748238 4257 4730474
SGTC_680 0417-1641 114 µM -1.20095919889082 0.124583283267768 no 2992 0.114883514358562 4287 2835990
SGTC_1515 3460-0031 42.1 µM -1.20297230838408 0.12417017544369 no 2993 0.114493518342959 4235 2876596
SGTC_191 3914-0123 66.505 µM -1.20692849405838 0.123361125639454 no 2994 0.113729841550376 4308 3144412
SGTC_2214 7179297 48.276 µM -1.2073783149438 0.123269370520099 no 2995 0.113643241424355 4348 769744
SGTC_3109 9122853 49.47 µM -1.21065881778719 0.122601654795666 no 2996 0.113013095938619 4319 1234709
SGTC_1468 k284-1086 134 µM -1.21068303596504 0.122596734865396 no 2997 0.113008453206915 4290 15996457
SGTC_3276 9139060 49.47 µM -1.21245281555303 0.122237578438543 no 2998 0.112669546997825 4405 4870619
SGTC_1049 3226-0134 66 µM -1.214204578418 0.121882806341783 no 2999 0.112334806306952 4327 5702385
SGTC_345 1362-0200 395 µM -1.21837430143733 0.121041253627452 no 3000 0.111540883128817 4294 1419823
SGTC_3112 9123419 49.47 µM -1.2195614765861 0.120802401869972 no 3001 0.111315578796207 4351 17015854
SGTC_234 nsc-17383 10.7 µM -1.21957351546868 0.120799981427028 no 3002 0.111313295704228 4325 408974
SGTC_1180 1193-0155 285 µM -1.22095689925605 0.120522076460535 no 3003 0.111051169596719 4373 2921347
SGTC_3200 9114385 49.47 µM -1.22198876534251 0.120315080479384 no 3004 0.110855937766558 4304 17018030 YLR208W SEC13
SGTC_2376 9072922 81.32 µM -1.22206890548273 0.120299014571276 no 3005 0.11084078533399 4311 17087968
SGTC_1770 st043884 66.3 µM -1.23188044298458 0.118343476884479 no 3006 0.108996873967731 4317 670149
SGTC_3119 9125183 49.47 µM -1.23270095394877 0.118180964999865 no 3007 0.108843677902696 4145 22695334
SGTC_682 0kpi-0099 17 µM -1.23387987438103 0.117947742255938 no 3008 0.108623834984108 4326 1714895 YML126C ERG13
SGTC_1018 4259-0013 28.1 µM -1.23528636777188 0.117669925532026 no 3009 0.108361972709139 4363 6801262
SGTC_2956 9076196 2.52 µM -1.23587334699648 0.117554119918626 no 3010 0.108252822815442 4311 16423868
SGTC_389 tpck 16.7 µM -1.23772643943518 0.117189051304386 no 3011 0.107908756070117 4363 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1766 st045414 44.774 µM -1.24108936729576 0.1165285902345 no 3012 0.107286368498262 4325 253960
SGTC_508 roscovitine 141 µM -1.24508075922967 0.115748133677837 no 3013 0.106551032969951 4382 160355 A CDKinase inhibitor.
SGTC_2191 5911152 200 µM -1.2469558628531 0.115382769945803 no 3014 0.106206840868924 4340 2875902
SGTC_1888 azatryptophan 97.5 µM -1.24758368892375 0.115260621459282 no 3015 0.106091777420741 4376 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2786 7743617 45.45 µM -1.24768124530731 0.115241649354081 no 3016 0.106073906075883 4278 583674
SGTC_2604 4'-hydroxychalcone 11.32 µM -1.24770259766499 0.115237497188204 no 3017 0.106069994829601 4341 5282362
SGTC_2114 5491910 81.25 µM -1.24822968159438 0.115135034495902 no 3018 0.105973478566366 4368 2849228
SGTC_1342 1486-1464 234 µM -1.2491746385816 0.114951501399658 no 3019 0.105800602949962 4360 3253938
SGTC_2256 7954252 200 µM -1.25429071682773 0.11396145025625 no 3020 0.104868178440033 4336 2972920
SGTC_1849 st056239 19.2 µM -1.26765199720341 0.111404501149698 no 3021 0.102461127133309 4327 5393181
SGTC_1897 st060201 15 µM -1.26770622486571 0.111394207949723 no 3022 0.102451440494871 4350 611878
SGTC_303 1348-1668 34.2 µM -1.26823166105102 0.111294507760784 no 3023 0.102357616784446 4346 5380509
SGTC_2364 9055074 200 µM -1.26890831845085 0.111166207853078 no 3024 0.102236882557607 4348 6470630
SGTC_1078 idebenone 36.1 µM -1.26965971554518 0.111023860809549 no 3025 0.102102934139091 4387 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_377 3970-0964 33.1 µM -1.27173875582572 0.11063068128803 no 3026 0.101732977811054 4310 16481235
SGTC_3123 9126162 49.47 µM -1.27317074917866 0.110360449651636 no 3027 0.1014787289191 4380 25239884
SGTC_395 anisomycin 6.25 µM -1.27435466429758 0.110137390569713 no 3028 0.101268875788197 4348 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2251 lansoprazole 556 µM -1.28045341076883 0.108993461416654 no 3029 0.100192859970736 4294 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2805 7950783 58.44 µM -1.28067098441987 0.108952809944142 no 3030 0.100154627731612 4355 1178958 YDL195W SEC31
SGTC_2183 6420625 130.508 µM -1.28120652618758 0.108852795724563 no 3031 0.100060567220399 4362 2897619
SGTC_2607 solasodine 47.35 µM -1.28557557997507 0.108039325457855 no 3032 0.0992956119026546 4327 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2453 5731132 22.18 µM -1.28579973585743 0.107997708432529 no 3033 0.0992564812230268 4392 1362040
SGTC_78 0336-0123 156.75 µM -1.28680895340439 0.107810478982465 no 3034 0.0990804427329619 4186 6765896
SGTC_1522 st012842 45.6 µM -1.28860259114185 0.107478301575074 no 3035 0.0987681410762304 4207 3491067 YOR116C RPO31
SGTC_1627 st003713 25.6 µM -1.28930084708381 0.107349185927056 no 3036 0.0986467583078493 4368 16195070 YER133W GLC7
SGTC_2603 homopterocarpin 100 µM -1.2913551442103 0.106969970969435 no 3037 0.0982902785517656 4334 101795 A weak amylase inhibitor.
SGTC_1665 st014639 11.4 µM -1.29151586643499 0.106940343105738 no 3038 0.0982624284617715 4428 981133 YIL048W NEO1
SGTC_217 ketoconazole 989 nM -1.2922956180249 0.106796686131408 no 3039 0.0981273944541763 4181 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1365 1672-3266 55.4 µM -1.29237320836311 0.106782398952345 no 3040 0.0981139651357241 4387 6415873
SGTC_2645 abamectin 100 µM -1.29259984949769 0.106740674045438 no 3041 0.0980747458497054 4311 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2014 4013930 200 µM -1.29271475431492 0.106719524424893 no 3042 0.0980548664475819 4330 64556
SGTC_583 1488-1091 88.9 µM -1.29335218643273 0.106602252260906 no 3043 0.0979446394901154 4464 4303273
SGTC_1187 1391-0724 117 µM -1.29340988873607 0.106591641019407 no 3044 0.0979346658930811 4406 6997986
SGTC_607 4491-0986 66.8 µM -1.3005544412572 0.105283669668746 no 3045 0.0967055050063583 4369 698981 YDR232W HEM1
SGTC_1777 st045864 34.765 µM -1.30133830145499 0.105140876387394 no 3046 0.0965713412066597 4357 4691462
SGTC_841 0251-0215 91.2 µM -1.30286896570578 0.104862444381909 no 3047 0.0963097503494644 4402 3888614
SGTC_2714 st079313 56.9 µM -1.31342497020678 0.102956804814645 no 3048 0.0945198939924533 4364 2939799
SGTC_2482 5981709 142.65 µM -1.31385957606903 0.102878889682035 no 3049 0.09444673222235 4309 877755
SGTC_51 1013-0126 23.419 µM -1.31766856678349 0.102197855140516 no 3050 0.0938073107029351 4389 1627850
SGTC_2016 5121758 140 µM -1.32009269278784 0.101766140866616 no 3051 0.0934020360803112 4319 2795203
SGTC_714 4296-0578 26.1 µM -1.32044740384855 0.101703081639005 no 3052 0.0933428427711228 4430 1589775
SGTC_796 1234-0020 70.7 µM -1.32084498806916 0.101632434398528 no 3053 0.0932765278403763 4318 46495034
SGTC_1801 st050089 28.441 µM -1.32243226024083 0.101350746106629 no 3054 0.0930121261700664 4418 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2617 dihydrotanshinone i 20.83 µM -1.32259752070354 0.101321450566943 no 3055 0.0929846295953535 4344 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_691 1548-0686 185 µM -1.32436628493366 0.101008289980855 no 3056 0.0926907130705203 4354 46495133
SGTC_3302 9125395 16.351 µM -1.32539696613615 0.100826133028138 no 3057 0.0925197613699757 4328 17599668
SGTC_2772 vinpocetine 57.06 µM -1.32784406454339 0.100394605997833 no 3058 0.0921148132586792 4397 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1967 st070177 51.4 µM -1.32888575234214 0.100211321879827 no 3059 0.0919428325354182 4404 5729214
SGTC_1287 0971-0001 34.6 µM -1.33142412989471 0.0997657194542602 no 3060 0.0915247470230132 4373 4665869
SGTC_173 1273-0061 2.693 µM -1.33225276573788 0.0996205694724772 no 3061 0.0913885713930213 4353 2847414 YPL266W DIM1
SGTC_2951 9072950 58.06 µM -1.34087614038151 0.09811918589909 no 3062 0.0899803350050054 4320 16488155
SGTC_2036 5160441 105 µM -1.34327370950367 0.0977047145132276 no 3063 0.0895916809054243 4363 134534 YIL048W NEO1
SGTC_853 0419-0306 21 µM -1.35184170468105 0.0962340428237933 no 3064 0.0882129797754661 4423 762713
SGTC_1196 1588-0294 184 µM -1.35281022688838 0.0960688279147583 no 3065 0.0880581323697865 4434 6144269
SGTC_1953 st076800 12.1 µM -1.353263488893 0.0959915801049347 no 3066 0.0879857344592175 4395 297591
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.35831117997098 0.0951344051085669 no 3067 0.0871824821169796 4408 6708760
SGTC_2731 amoxapine 43.43 µM -1.35949259554591 0.0949345992922276 no 3068 0.0869952736141724 4566 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1427 4048-4900 550 nM -1.35960587781879 0.0949154567881302 no 3069 0.0869773385606046 4401 24132586
SGTC_616 4092-0450 108 µM -1.36058965741548 0.0947493367109487 no 3070 0.0868217009311273 4406 787165
SGTC_2849 9019321 12.99 µM -1.36117296417865 0.0946509413300865 no 3071 0.0867295179307215 4420 16489627
SGTC_13 0199-0087 65 µM -1.3613732487177 0.0946171736127368 no 3072 0.0866978827984494 4501 4589825
SGTC_1202 1988-0068 29.6 µM -1.36195669672215 0.0945188556393849 no 3073 0.0866057757871001 4380 2850480
SGTC_1076 itraconazole 331 nM -1.36713741815664 0.0936491438904002 no 3074 0.0857911183572374 4413 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1444 4112-3581 28 µM -1.36887683817888 0.0933584684334426 no 3075 0.0855188884813298 4494 2877249
SGTC_2184 6075246 200 µM -1.37138445178238 0.0929405935427465 no 3076 0.0851275708726057 4395 2267320
SGTC_2464 5717415 7.67 µM -1.37360077340785 0.0925724128282223 no 3077 0.0847828283465781 4376 5285744
SGTC_2366 9070441 60.58 µM -1.37865232418771 0.091737271155126 no 3078 0.0840009877819971 4391 6837235
SGTC_225 nsc-122657 1.016 µM -1.37985232819366 0.0915397048887139 no 3079 0.0838160585531081 4437 275685
SGTC_3066 9117245 49.47 µM -1.38015061509576 0.0914906444947503 no 3080 0.0837701378886709 4464 17176980
SGTC_1117 retinoic acid 1.10837 µM -1.38653974773411 0.0904444734656261 no 3081 0.0827910759810264 4462 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1153 4055-0057 267 µM -1.38691840520031 0.0903827511980916 no 3082 0.0827333224367732 4468 882706
SGTC_25 0118-0223 35.662 µM -1.38804246204637 0.0901997109110883 no 3083 0.0825620577659318 4420 5333628
SGTC_116 0155-0182 31.788 µM -1.38806830248363 0.0901955063203772 no 3084 0.082558123779798 4287 771486
SGTC_1990 st072050 59.8 µM -1.39281095449247 0.089426275499486 no 3085 0.0818384824642502 4419 17233948
SGTC_1070 indatraline 8.81 µM -1.39397379099277 0.0892384171830972 no 3086 0.0816627596339534 4488 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1477 0139-0234 16 µM -1.39561053122481 0.0889744966067458 no 3087 0.0814159046967357 4434 620880
SGTC_954 1189-0853 2.85 µM -1.39688506518746 0.0887693836750815 no 3088 0.0812240681970032 4350 2828194
SGTC_2752 diclazuril 33.15 µM -1.40262080888135 0.0878506770996489 no 3089 0.0803649716271323 4357 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_3079 9117512 49.47 µM -1.40315596968363 0.0877653222689914 no 3090 0.0802851670525252 4522 7185044
SGTC_3182 9108849 49.47 µM -1.40623165491988 0.0872759686539813 no 3091 0.0798276736363723 4458 17133045
SGTC_1465 k213-0056 144 µM -1.4085366683359 0.0869105694484937 no 3092 0.0794861085090132 4346 24048857 YMR208W ERG12
SGTC_2286 7945697 125 µM -1.40874189555135 0.0868780915668861 no 3093 0.0794557509092981 4427 1245733
SGTC_2414 st077232 92.9 µM -1.41016001548613 0.0866539171925743 no 3094 0.0792462196713888 4371 729801
SGTC_2168 5727979 200 µM -1.41570436983842 0.0857816220007941 no 3095 0.0784310392149837 4348 695210
SGTC_3134 9127454 49.47 µM -1.41877407057084 0.0853015005813567 no 3096 0.0779824472486245 4496 24262820
SGTC_555 4296-0685 37 µM -1.41987305114182 0.0851301030590258 no 3097 0.0778223213922959 4433 2908540 YHR072W ERG7
SGTC_2878 9043973 25.97 µM -1.4250832199101 0.084321033505138 no 3098 0.0770665732853939 4466 6465167
SGTC_574 1315-0397 40 µM -1.42920814393407 0.0836845913123714 no 3099 0.076472208835483 4440 6794277
SGTC_2124 5246320 200 µM -1.42936978274086 0.083659725442936 no 3100 0.0764489893398256 4458 579342
SGTC_3268 9137683 49.47 µM -1.43161834548749 0.0833143910189047 no 3101 0.0761265382177463 4521 1953228
SGTC_21 0849-0113 22.993 µM -1.43751017167151 0.0824146077531202 no 3102 0.0752865423538772 4422 1560156
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.43831443002949 0.0822923533651741 no 3103 0.0751724296989638 4443 688803
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.43985476927635 0.0820585895162923 no 3104 0.0749542460157628 4537 688801
SGTC_1423 4048-0112 5.59 µM -1.44023710774546 0.0820006429183808 no 3105 0.0749001640066444 4513 X1423
SGTC_1917 st066507 28.5 µM -1.44112700586234 0.0818658908044531 no 3106 0.0747744026534632 4406 3156428
SGTC_422 cantharidin 155 µM -1.44299392777146 0.0815837360485218 no 3107 0.0745110908895285 4383 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2729 fluphenazine 10.66 µM -1.44572545760209 0.0811722320473404 no 3108 0.0741271105115418 4403 3372 An atypical antipsychotic.
SGTC_3326 9140064 16.379 µM -1.44637226066346 0.0810750211225134 no 3109 0.074036408938973 4420 1868434
SGTC_8 0354-0001 70 µM -1.44650021295339 0.0810558010143037 no 3110 0.0740184761641658 4465 4993152
SGTC_3169 9102970 49.47 µM -1.44883204198254 0.0807061318948761 no 3111 0.0736922465940294 4540 17027839
SGTC_1038 k292-0204 154 µM -1.44954985091323 0.0805987225788647 no 3112 0.0735920446378543 4405 4454212
SGTC_35 0133-0054 64.071 µM -1.44971377170675 0.0805742094465088 no 3113 0.0735691768650411 4435 99677
SGTC_3008 9078912 71.4286 µM -1.45274806444866 0.0801214699001448 no 3114 0.073146858290719 4489 16648731
SGTC_2132 5317594 122.667 µM -1.45443141936299 0.0798711313041799 no 3115 0.0729133671621225 4406 794577
SGTC_1127 asiatic acid 681.4 nM -1.45617073541183 0.0796130923233305 no 3116 0.0726727136393193 4427 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1249 0481-0015 10.2 µM -1.45789524073727 0.0793578738077041 no 3117 0.0724347103338133 4410 4227577
SGTC_901 1112-0062 60.1 µM -1.45817896933706 0.0793159427301703 no 3118 0.072395609510733 4455 1908457
SGTC_2495 cafestol 54.53 µM -1.46620349069814 0.078136965090042 no 3119 0.0712964289611365 4467 16667697 An anti-infammatory.
SGTC_1290 0986-0249 10.2 µM -1.47005772220321 0.0775754417513207 no 3120 0.0707730606944389 4329 53329
SGTC_1302 1159-0335 255 µM -1.47319709863499 0.0771203342858053 no 3121 0.0703489485980716 4491 649284
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.47415295321369 0.0769821701555503 no 3122 0.0702202068741136 4529 5282309
SGTC_2900 5328528 85.29 µM -1.47456683490381 0.0769224039713802 no 3123 0.0701645184061642 4483 795359
SGTC_1840 st055363 71 µM -1.47654867371044 0.0766367071804402 no 3124 0.0698983293751638 4505 676033
SGTC_3288 9119690 36.221 µM -1.47818025757664 0.0764021085038195 no 3125 0.0696797683570046 4469 17595618 YKL019W RAM2
SGTC_3043 9092303 49.47 µM -1.48188716847608 0.0758711385340149 no 3126 0.0691851599167895 4491 25236084
SGTC_1951 sophoraflavanone G 9.2 µM -1.50265429751969 0.0729483372443753 no 3127 0.0664641068983212 4434 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_3319 9138450 16.7555 µM -1.50803973144442 0.072204639727438 no 3128 0.0657721792841248 4436 2029690
SGTC_3309 9129340 25.759 µM -1.51181520189826 0.0716867435471588 no 3129 0.0652904404992309 4489 17158987
SGTC_1324 1418-0026 34.4 µM -1.51292242895143 0.0715354025207175 no 3130 0.0651496819741647 4526 1372513
SGTC_909 3448-9333 149 µM -1.51563229311268 0.071166039827283 no 3131 0.0648061783415242 4432 3344074
SGTC_2926 9010726 65.15 µM -1.51607836643029 0.0711053792997308 no 3132 0.0647497689243954 4491 2994293
SGTC_3067 9117431 49.47 µM -1.52285296700837 0.0701889896938803 no 3133 0.0638977474747657 4512 17150885
SGTC_2092 5303694 80.6725 µM -1.52619676700899 0.0697400404348002 no 3134 0.0634804341939721 4521 1963699
SGTC_2202 7226349 200 µM -1.52666155300607 0.0696778121533032 no 3135 0.0634225962189744 4511 844334
SGTC_3058 9093861 49.47 µM -1.52707165833964 0.0696229403461953 no 3136 0.0633715967766316 4512 17217477
SGTC_1403 3909-7815 62.9 µM -1.52793071335569 0.0695081072264748 no 3137 0.0632648708048615 4512 6615483
SGTC_3254 9136651 49.47 µM -1.52874149402212 0.0693998609598853 no 3138 0.0631642706849419 4483 16454030
SGTC_2931 9014674 55.67 µM -1.52921656123874 0.0693364957102171 no 3139 0.0631053831552293 4465 2996810
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.5295594354599 0.069290790276904 no 3140 0.0630629083396202 4431 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_3280 9140961 49.47 µM -1.53094212413678 0.0691067121535282 no 3141 0.0628918485660681 4533 4901226
SGTC_126 0417-1624 672.48 µM -1.53221529886662 0.0689375471502388 no 3142 0.0627346572353493 4555 41912 YDL195W SEC31
SGTC_1667 st014849 34.6 µM -1.53243261068293 0.0689087051411486 no 3143 0.0627078576508955 4598 5348460
SGTC_1376 2910-0861 41.3 µM -1.53370512561966 0.0687400013848357 no 3144 0.0625511061166824 4448 1112859
SGTC_907 3448-6986 75.5 µM -1.53387241371754 0.0687178468603394 no 3145 0.0625305218931081 4517 590582
SGTC_903 1134-0042 114 µM -1.54026967849135 0.0678747601840523 no 3146 0.0617473157860174 4520 701009
SGTC_2911 7942208 15.64 µM -1.54734435233026 0.0669517247793967 no 3147 0.0608901160786583 4533 1243384
SGTC_2735 sertaconazole 140 nM -1.54802968834402 0.0668628270939838 no 3148 0.0608075744144419 4642 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_681 1642-0006 26.6 µM -1.54810912611844 0.0668525288100439 no 3149 0.060798012614135 4534 4446530
SGTC_2925 9010536 32.5 µM -1.54913374622215 0.0667198074039889 no 3150 0.0606747860625466 4439 2994177
SGTC_2344 7990960 76.95 µM -1.54948770726472 0.0666740054294726 no 3151 0.0606322621541636 4504 140813
SGTC_1841 st054148 70 µM -1.5553423725073 0.0659199464114409 no 3152 0.0599322754419581 4543 675442
SGTC_1983 st071813 46.9 µM -1.55744550712963 0.0656506897651225 no 3153 0.0596823744345545 4588 11838595
SGTC_3143 9086658 49.47 µM -1.55751744484108 0.0656414949469039 no 3154 0.0596738410350356 4494 25236626
SGTC_1337 1486-1011 40.3 µM -1.56090775426817 0.0652092891719155 no 3155 0.0592727587284648 4522 X1337
SGTC_2029 5175081 200 µM -1.56286358724521 0.0649609605394782 no 3156 0.0590423419547254 4493 1380876
SGTC_1919 st067113 52.3 µM -1.56296754318132 0.0649477820133958 no 3157 0.0590301145948499 4497 1268243
SGTC_3138 9097216 49.47 µM -1.56547534111956 0.0646304962007087 no 3158 0.0587357474390378 4457 25237486
SGTC_3201 9113999 49.47 µM -1.56866877389471 0.0642282082578589 no 3159 0.0583625691131462 4507 16649224
SGTC_2095 5432005 200 µM -1.56975450141352 0.0640918795690632 no 3160 0.0582361181585518 4547 783734
SGTC_475 α-linolenic acid 10 µM -1.57042381923271 0.0640079492564116 no 3161 0.0581582723137973 4523 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3181 9108277 49.47 µM -1.57316440826268 0.063665179257324 no 3162 0.0578403771325524 4504 17097298
SGTC_2471 5466956 24.79 µM -1.57522251764512 0.0634087083644019 no 3163 0.0576025456745591 4538 724419
SGTC_1074 carmofur 3.8 µM -1.57780624242255 0.0630878773609974 no 3164 0.0573050646518667 4573 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3025 9087895 49.47 µM -1.58109417913801 0.0626814314535215 no 3165 0.0569282527364905 4519 17173641
SGTC_2115 tiliquinol 12.7705 µM -1.58654684961214 0.0620118891913937 no 3166 0.0563076566862616 4519 71208 A bioactive hydroxyquinoline.
SGTC_2394 5221648 200 µM -1.58929307561446 0.0616767954518868 no 3167 0.055997120658404 4563 788586
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.60008806279228 0.0603732787257641 no 3168 0.0547895243892717 4551 75037 A free radical scavenger.
SGTC_2326 6164455 177.58 µM -1.60028059217855 0.0603502276347836 no 3169 0.0547681751666838 4477 2888790
SGTC_856 0433-0016 11.3 µM -1.60550469637329 0.0597273832274055 no 3170 0.0541913902400574 4570 3911780
SGTC_858 0438-0351 2.77 µM -1.60586859738615 0.0596841854172535 no 3171 0.0541513922757908 4534 2799119
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.60943425260615 0.0592622091382375 no 3172 0.0537607103021256 4526 97141
SGTC_1838 st055369 84.5 µM -1.61119357103724 0.0590548668982786 no 3173 0.0535687693117642 4525 676036
SGTC_2391 6285546 200 µM -1.61876277491762 0.0581692920579131 no 3174 0.0527491571709478 4561 846083
SGTC_2870 9038528 12.99 µM -1.62376550353108 0.0575897373292909 no 3175 0.0522129325052443 4573 6463316
SGTC_2769 toremifene 3.73 µM -1.62828548031652 0.0570700224375774 no 3176 0.0517321833857784 4549 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2759 disulfiram 3.38 µM -1.62832375402281 0.0570656374767525 no 3177 0.0517281276316539 4458 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2557 derrustone 83.84 µM -1.62983943235383 0.0568922016267403 no 3178 0.0515677186695307 4519 629853 An antioxidant.
SGTC_833 3852-0053 558 µM -1.63223289217118 0.0566191687113577 no 3179 0.0513152170652598 4605 3123681
SGTC_2264 7948757 110.76 µM -1.63317712918052 0.0565117396679229 no 3180 0.0512158743237461 4530 2971411
SGTC_560 2332-1943 155 µM -1.63584558912487 0.0562090082106336 no 3181 0.0509359539855433 4557 21177716
SGTC_2294 7971431 200 µM -1.64346720333734 0.0553513896317809 no 3182 0.0501431528068064 4548 5741572
SGTC_124 0136-0217 7.121 µM -1.64889680369661 0.054746753866376 no 3183 0.0495843890398999 4612 3976905
SGTC_1104 tacrolimus 29.8 µM -1.65397796940185 0.0541856603781962 no 3184 0.0490659945127268 4625 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2138 5575593 77.673 µM -1.66257430055287 0.053246772928762 no 3185 0.0481988394889084 4575 762213
SGTC_1191 1487-1166 10.6 µM -1.66576040566428 0.052902081255812 no 3186 0.0478805726308274 4585 3955771
SGTC_200 k038-0079 37.545 µM -1.66817216778716 0.0526423414033215 no 3187 0.0476407771185487 4583 3436683
SGTC_1071 trifluoperazine 6.31 µM -1.66939489432816 0.052511044414156 no 3188 0.0475195724181549 4620 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_904 1141-0088 396 µM -1.67254113749811 0.0521743940278146 no 3189 0.0472088314931456 4591 1378119
SGTC_3053 9095903 49.47 µM -1.67488063451185 0.0519251790934882 no 3190 0.0469788269534643 4673 17174018
SGTC_1679 SEC14.276 6.7 µM -1.6762205063009 0.0517828758010661 no 3191 0.0468475044766242 4539 1005053 YMR079W SEC14
SGTC_90 0870-0863 4.608 µM -1.67683859487177 0.0517173352456218 no 3192 0.0467870241825393 4595 1738164
SGTC_579 4491-1009 110 µM -1.6778943155259 0.051605541805449 no 3193 0.0466838662297615 4635 1271041
SGTC_1263 0774-1208 64.8 µM -1.69183297436179 0.050147479116138 no 3194 0.0453389122566106 4572 906585
SGTC_2377 9073351 62.6 µM -1.6924971950756 0.0500788261760944 no 3195 0.0452756072348545 4583 7337946 YHR072W ERG7
SGTC_698 k064-0052 127 µM -1.69986497773485 0.0493223177809637 no 3196 0.044578162935497 4664 5088751
SGTC_3022 9087993 49.47 µM -1.70458307056795 0.0488426853786843 no 3197 0.0441361054864911 4652 17173644
SGTC_854 0422-0053 192 µM -1.72000429684466 0.0473009467379618 no 3198 0.0427158302655417 4618 3596728
SGTC_139 0099-0334 718.624 µM -1.72011201488667 0.047290316406276 no 3199 0.042706041077368 4587 97690
SGTC_2085 5307070 144.047 µM -1.72101094220083 0.0472016789318372 no 3200 0.0426244191607917 4538 2840351
SGTC_1674 st016616 23.6 µM -1.72608324541345 0.0467040244522227 no 3201 0.0421662187974371 4563 625830
SGTC_2639 lactacystin 53 µM -1.73397663062296 0.0459379692177634 no 3202 0.0414611148606776 4605 3870 A proteasome inhibitor.
SGTC_955 1216-0110 33 µM -1.75081393132134 0.04433763896916 no 3203 0.0399889830484013 4598 3619719
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.75093603106032 0.0443262000251156 no 3204 0.039978464732474 4533 5355888
SGTC_2792 7535235 81.82 µM -1.75722109904164 0.0437405869055466 no 3205 0.0394400651427853 4577 1281891
SGTC_1181 1222-0449 220 µM -1.75915196976575 0.0435619361111741 no 3206 0.0392758498743801 4631 658318
SGTC_1952 st077036 64.1 µM -1.76066414866431 0.0434224357138623 no 3207 0.0391476320786547 4627 2937007
SGTC_421 streptovitacin 30 mM -1.76093692586454 0.0433973101123921 no 3208 0.0391245395864267 4580 91467 include heat shock
SGTC_902 1120-0002 2.07 µM -1.76432125239286 0.0430865537978584 no 3209 0.0388389539241096 4591 3280475
SGTC_2734 clemastine 41.6 µM -1.7685617397686 0.0426997228178299 no 3210 0.0384835202132172 4680 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_114 0364-0001 490.298 µM -1.77114005916404 0.0424658959308379 no 3211 0.0382687069682021 4609 4003655
SGTC_572 0960-0087 17.7 µM -1.77522428991652 0.0420976189996475 no 3212 0.0379304302936858 4580 6796365
SGTC_2301 7769476 200 µM -1.77920016030051 0.0417416001230134 no 3213 0.0376034760578333 4611 977820
SGTC_2091 4-phenylthiadiazole 200 µM -1.78239947574684 0.0414568917345671 no 3214 0.0373420554747654 4633 270010
SGTC_2690 usnic acid 100 µM -1.78854501423277 0.0409144130226322 no 3215 0.036844060000545 4615 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_119 0121-0043 24.815 µM -1.80646854184442 0.0393650858707008 no 3216 0.0354225918269844 4629 1092378
SGTC_3320 9137005 35.139 µM -1.80749670346838 0.0392776783561747 no 3217 0.0353424341126858 4647 4908713
SGTC_1171 0368-0077 21.4 µM -1.80751549377392 0.039276082399226 no 3218 0.0353409705650258 4603 3239779
SGTC_2954 9074818 52.69 µM -1.81083595936461 0.0389948857757648 no 3219 0.035083124077952 4616 16648742
SGTC_2343 7990716 14.84 µM -1.81456730608196 0.0386808516283992 no 3220 0.0347952153002272 4630 6456862
SGTC_3220 9131269 49.47 µM -1.81696701271613 0.0384799806045563 no 3221 0.0346110822486906 4627 17722206
SGTC_831 k061-1017 217 µM -1.82062478920552 0.0381754373435368 no 3222 0.0343319559915547 4655 1240153
SGTC_2815 7968870 71.43 µM -1.82191926767587 0.0380681322524205 no 3223 0.0342336181517442 4554 2977326 YHR190W ERG9
SGTC_774 k060-0086 136 µM -1.82748704267696 0.0376093961015014 no 3224 0.0338132863239798 4633 5911235
SGTC_596 1155-0152 116 µM -1.82941567901613 0.0374515496188781 no 3225 0.0336686802791546 4658 280313
SGTC_1898 st060199 18.6 µM -1.85473187827354 0.0354293068648562 no 3226 0.0318172620632936 4656 688866
SGTC_359 0081-0058 15.9 µM -1.85558931302437 0.03536241479515 no 3227 0.0317560590633143 4618 3494159
SGTC_1269 0831-0796 3.05 µM -1.85580146759534 0.0353458797243651 no 3228 0.0317409306614096 4662 927758
SGTC_982 1491-0518 27.5 µM -1.85757163013477 0.0352081624351412 no 3229 0.0316149351897012 4623 3091256
SGTC_1761 st044296 37 µM -1.85774485619455 0.0351947092592635 no 3230 0.0316026276526749 4665 1826700
SGTC_2698 st077697 67.5 µM -1.85975284208105 0.0350390715320913 no 3231 0.0314602510484514 4618 3154499
SGTC_445 e6 berbamine 66 µM -1.86006724878872 0.035014753285495 no 3232 0.0314380060724925 4640 6610268 A calcium/calmodulin antagonist.
SGTC_2135 5326629 150.42 µM -1.86086494853154 0.0349531161808193 no 3233 0.0313816253813399 4617 5020077
SGTC_252 miconazole 1.30953 nM -1.87108877394634 0.0341709924651556 no 3234 0.0306663886697649 4574 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2947 9072639 7.68 µM -1.8791112006658 0.0335673999987185 no 3235 0.0301146555387145 4588 16488146
SGTC_3264 9137442 49.47 µM -1.88071860033223 0.0334475237916824 no 3236 0.0300051040383888 4614 17015726
SGTC_1436 4092-1007 8.32 µM -1.8860082211351 0.0330555219646458 no 3237 0.0296469234098308 4669 2881121
SGTC_258 haloperidol 50.781 µM -1.88748481638225 0.0329467732021175 no 3238 0.0295475733377849 4646 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3135 9127742 49.47 µM -1.89210409254298 0.0326084738069972 no 3239 0.0292385565794703 4684 3643468
SGTC_3167 9103034 49.47 µM -1.90136764783135 0.0319386754526446 no 3240 0.0286269370114238 4719 5127859
SGTC_455 paf C-16 10 µM -1.90619939737159 0.0315938512451788 no 3241 0.0283121702030195 4636 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_643 k048-0106 28.4 µM -1.91485641873899 0.0309837279578651 no 3242 0.0277554085213096 4688 6763920
SGTC_2528 xanthyletin 44.79 µM -1.91507203951682 0.0309686569265392 no 3243 0.0277416585233044 4667 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3244 9134489 49.47 µM -1.91816905333606 0.0307528565812968 no 3244 0.0275447894278413 4660 16584271
SGTC_1336 1486-0901 104 µM -1.92406219323089 0.0303456601771545 no 3245 0.0271733941386088 4666 5006114
SGTC_890 0929-0006 47.2 µM -1.92884601112516 0.0300184087594746 no 3246 0.0268749909429828 4666 1378169
SGTC_1159 4092-0538 61.2 µM -1.93085528980677 0.0298818334224858 no 3247 0.0267504753154606 4688 717301
SGTC_850 0388-0143 75.9 µM -1.95475940315794 0.0282961967460854 no 3248 0.0253057374764825 4679 67273
SGTC_2998 9066762 71.4286 µM -1.95937799212404 0.0279980483769058 no 3249 0.0250342680407656 4664 4945196
SGTC_137 0438-0332 85.389 µM -1.96056714185443 0.0279217089628298 no 3250 0.0249647692592005 4612 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_3197 9113331 49.47 µM -1.96261122400187 0.0277908909467884 no 3251 0.0248456827685422 4645 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_3098 9119039 49.47 µM -1.97875785018503 0.0267753784245101 no 3252 0.0239216380933812 4670 17161528
SGTC_1021 4476-0760 85.3 µM -1.99087398801732 0.0260338689643515 no 3253 0.0232473712933295 4699 746768
SGTC_1757 st041620 31.8375 µM -1.9927874319923 0.0259183512053379 no 3254 0.0231423642784357 4667 5289815
SGTC_1745 st081495 74 µM -2.00160420921924 0.0253915942806291 no 3255 0.0226636579755869 4562 13842402 YBL026W LSM2
SGTC_201 4262-0159 12.803 µM -2.00329301037426 0.0252917273762436 no 3256 0.0225729236454567 4724 1341029
SGTC_823 0417-1665 178 µM -2.00814434665786 0.0250066734925136 no 3257 0.0223139774784023 4699 3429856
SGTC_3165 9101544 49.47 µM -2.01533325540899 0.024589225267485 no 3258 0.0219348713483171 4691 5002184
SGTC_2247 cerulenin 830 nM -2.01539372388661 0.0245857389155188 no 3259 0.0219317057608004 4697 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1638 st008370 60.6 µM -2.0223719720421 0.0241861799929902 no 3260 0.0215689691740533 4651 24207134
SGTC_531 3788-1495 174 µM -2.0269847294 0.0239250693057039 no 3261 0.0213319871986384 4685 2896655
SGTC_2145 5634607 200 µM -2.03181104384622 0.0236544102680287 no 3262 0.0210863943683856 4691 308662
SGTC_187 1488-2104 32.728 µM -2.05662546654368 0.0223031481201222 no 3263 0.0198611333136666 4696 2852859
SGTC_756 0508-1999 28.3 µM -2.06370258812796 0.0219299158288223 no 3264 0.0195229619109358 4706 6753853
SGTC_2152 5568786 200 µM -2.06704009656488 0.0217557410126914 no 3265 0.0193651879436068 4729 5399883
SGTC_382 3229-0966 23.2 µM -2.07512970332915 0.0213384112065576 no 3266 0.0189872577498712 4710 5722370
SGTC_2773 thioridazine 9.09 µM -2.07705409735988 0.0212401376019751 no 3267 0.01889828326906 4695 5452 An antipsychotic.
SGTC_1850 st056238 17 µM -2.07719518132615 0.0212329479101305 no 3268 0.0188917742204383 4700 5393177
SGTC_1353 1498-1206 8.11 µM -2.0918355182958 0.0204979779382882 no 3269 0.0182266159425884 4712 6756808
SGTC_2163 5671233 125 µM -2.0950406921235 0.0203399813543038 no 3270 0.0180836876621888 4661 701023
SGTC_1754 st042065 16.137 µM -2.10442061399838 0.0198835240535595 no 3271 0.0176708864012251 4506 1126236 YIL048W NEO1
SGTC_3316 9136639 10.545 µM -2.13292408885026 0.018549443551983 no 3272 0.0164654769550488 4722 4903665
SGTC_708 3448-5400 146 µM -2.13423540564035 0.018489947763341 no 3273 0.0164117579125816 4680 3462195
SGTC_3172 9105863 49.47 µM -2.13551156638025 0.0184322031437799 no 3274 0.0163596232135554 4782 2348785
SGTC_1995 st072814 61.1 µM -2.14073070414191 0.0181976398384401 no 3275 0.0161478804807254 4722 5769371
SGTC_1676 st018489 23.4 µM -2.15031844925499 0.0177733643309592 no 3276 0.0157650170206149 4681 3696235
SGTC_1776 st049249 45.9 µM -2.15386149900009 0.0176187277128742 no 3277 0.0156255175393071 4727 1822314
SGTC_1643 st009866 20.2 µM -2.15386937917572 0.0176183850660401 no 3278 0.0156252084597305 4711 3156273 YOR207C RET1
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -2.16010905459251 0.0173488498337422 no 3279 0.0153821141206341 4703 5377381
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -2.16570075327943 0.0171103052234827 no 3280 0.0151670307235108 4761 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1887 st057648 70.8 µM -2.1698690229559 0.0169343134794662 no 3281 0.0150083848088184 4724 688672
SGTC_2316 5844804 197.44 µM -2.17450604485814 0.0167403510697174 no 3282 0.0148335759634605 4707 776813
SGTC_970 1315-0089 19.5 µM -2.17816939513156 0.0165884632206055 no 3283 0.0146967138424159 4712 6811083 YLR033W RSC58
SGTC_1270 0831-1170 17.3 µM -2.17848779442435 0.0165753178057352 no 3284 0.0146848699777706 4734 6764716
SGTC_43 0570-0105 72.5 µM -2.1840096202531 0.0163487580964625 no 3285 0.0144807705778015 4692 1114046 YDL195W SEC31
SGTC_2101 5377231 179.231 µM -2.18683837304665 0.016233725599299 no 3286 0.0143771625424928 4739 2844213
SGTC_2881 9058953 51.95 µM -2.18769023628411 0.0161992203244507 no 3287 0.0143460868784403 4691 17122249
SGTC_40 0327-0103 19.753 µM -2.19356161536777 0.0159631010115866 no 3288 0.0141334702297594 4598 409036
SGTC_1941 st076221 61.8 µM -2.19510522632021 0.0159015162355132 no 3289 0.0140780252047389 4642 2828568
SGTC_1019 4262-0212 3.4 µM -2.19518080055016 0.0158985063213922 no 3290 0.0140753154709575 4695 4677213
SGTC_1225 1216-0074 20.6 µM -2.20095877467523 0.0156698272534803 no 3291 0.0138694712232362 4718 4241466
SGTC_218 alverine citrate 93.75 µM -2.20201709619514 0.0156282485208771 no 3292 0.0138320504291443 4744 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1502 4534-4282 27.7 µM -2.2043617200623 0.0155364713300732 no 3293 0.0137494577673973 4740 3278949
SGTC_1260 0700-1617 7.75 µM -2.22254734542756 0.014840200515365 no 3294 0.0131231690592977 4701 2853078
SGTC_1803 st050068 52.4 µM -2.22579572528313 0.01471869692728 no 3295 0.0130139336427778 4719 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1800 st050079 29.0735 µM -2.23326678579321 0.014442489967115 no 3296 0.0127656782243429 4596 3645560
SGTC_2945 9067681 61.76 µM -2.23373996228477 0.0144251477728715 no 3297 0.0127500939664669 4737 16456930
SGTC_3045 9092950 49.47 µM -2.23883950308675 0.0142393815827759 no 3298 0.0125831804698891 4711 44120432
SGTC_3279 9140807 49.47 µM -2.24797575609643 0.0139117163515385 no 3299 0.0122888679422685 4758 45595718
SGTC_1454 4239-0054 42.6 µM -2.25572423279772 0.0136389379384774 no 3300 0.0120439534839104 4759 1340767
SGTC_190 3970-0790 3.722 µM -2.25970566949944 0.0135005787568415 no 3301 0.0119197621010215 4726 2832352
SGTC_2695 st077686 51.995 µM -2.26398780324413 0.0133531240362359 no 3302 0.0117874324739117 4705 2876092
SGTC_266 formosanin C 406 nM -2.26678965339221 0.0132573972453453 no 3303 0.011701539243484 4620 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_229 benomyl 22.8748 µM -2.29020346329178 0.0124803703581914 no 3304 0.0110047623836493 4764 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1335 1486-0900 202 µM -2.30691358767007 0.0119502210709592 no 3305 0.01052981894623 4736 X1335
SGTC_677 0929-0063 136 µM -2.32613627802125 0.011364616490805 no 3306 0.0100056408753969 4768 1539583
SGTC_1473 k844-0725 134 µM -2.32802129156425 0.0113085565689826 no 3307 0.0099554865595409 4770 54682906
SGTC_3285 9112818 20.8695 µM -2.35127376947029 0.0106365548634774 no 3308 0.00935463137357227 4745 17017947 YPR165W RHO1
SGTC_2816 7982706 58.44 µM -2.36289036005165 0.0103140575183482 no 3309 0.00906651665463574 4710 2981853
SGTC_1379 2144-0755 36.5 µM -2.36711987642902 0.0101987738741665 no 3310 0.0089635625585615 4755 5392327
SGTC_1373 2887-0003 58.5 µM -2.3749190459419 0.00998913724103704 no 3311 0.00877639971259044 4719 776948
SGTC_2841 9004761 38.96 µM -2.37642289184771 0.00994915025608463 no 3312 0.00874070735220131 4694 2991039
SGTC_628 1636-0253 16 µM -2.3872706846048 0.00966482672175175 no 3313 0.00848699422096605 4763 4456143
SGTC_1719 st032227 49.2 µM -2.39477899578496 0.0094722139184138 no 3314 0.00831519293464622 4739 3125804
SGTC_3091 9116372 49.47 µM -2.41969224674825 0.00885694831309638 no 3315 0.00776682367114237 4763 17169793
SGTC_3255 9139072 49.47 µM -2.45146198273085 0.00812334955662068 no 3316 0.00711386075435445 4758 17646060
SGTC_3335 9143315 29.6265 µM -2.49223452168009 0.00726043756979295 no 3317 0.0063471094207482 4754 4899691
SGTC_789 1309-1135 70.6 µM -2.5026500063823 0.007053400125086 no 3318 0.00616336879882107 4753 3092424
SGTC_1902 st060212 70.5 µM -2.51093969801364 0.00689236037849274 no 3319 0.00602051318442392 4757 688944
SGTC_2055 5235184 200 µM -2.51986807083079 0.00672255319830712 no 3320 0.00586994135350751 4740 2836034
SGTC_1203 3992-3522 103 µM -2.52608973042315 0.00660642063979636 no 3321 0.00576700088765808 4738 5322312
SGTC_2942 9052777 62.25 µM -2.53377710750219 0.00646538144751996 no 3322 0.00564202408582706 4751 6469503
SGTC_2137 5261020 140 µM -2.5550695954061 0.006088541978931 no 3323 0.00530832842476447 4762 763655
SGTC_2728 chlorpromazine 9.18 µM -2.5666066828016 0.00589259652029255 no 3324 0.00513495142388487 4797 2726 A thorazine and dopamine antagonist.
SGTC_3059 1327-0034 3 µM -2.57262957721782 0.00579254274808627 no 3325 0.00504645833199852 4688 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2049 5262831 67.185 µM -2.58147100531571 0.00564839727760718 no 3326 0.00491901275442312 4735 763417
SGTC_3224 9130643 49.47 µM -2.61224726313332 0.00517116296488555 no 3327 0.00449745859406124 4761 17644395
SGTC_3037 9091026 49.47 µM -2.64289306050066 0.00473194819872966 no 3328 0.00411004965653419 4688 25236398 YIL048W NEO1
SGTC_2319 6033012 152.6 µM -2.68273462512691 0.00421081608579212 no 3329 0.00365114547610834 4753 847246
SGTC_1065 prochlorperazine maleate 2.48 µM -2.71976828940829 0.00377308742658928 no 3330 0.00326638378768209 4785 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2865 9030313 51.95 µM -2.73465957684843 0.00360889906454296 no 3331 0.00312224096763474 4776 42562754
SGTC_2869 9037858 32.47 µM -2.73480013612446 0.00360738032163242 no 3332 0.00312090812088062 4769 27187042
SGTC_3097 9117246 49.47 µM -2.73593979962546 0.00359508742337823 no 3333 0.00311012021468185 4786 16423892
SGTC_2155 5570423 76 µM -2.74030377839266 0.00354836258042568 no 3334 0.00306912109323869 4774 797402
SGTC_693 4161-2696 114 µM -2.76209555650539 0.00332310024364908 no 3335 0.00287158335162242 4795 805759
SGTC_1778 st046819 58.9 µM -2.81391986329389 0.00283818022504923 no 3336 0.00244707136146168 4792 671715
SGTC_788 1182-0090 188 µM -2.8565047979485 0.0024885392202187 no 3337 0.00214166765280905 4763 5715185
SGTC_327 1273-0057 3.96 µM -2.87674539739781 0.00233642607201612 no 3338 0.00200899820500555 4765 3108138
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -2.90260013756014 0.00215438093530684 no 3339 0.00185039412110775 4781 6857784
SGTC_2292 7671323 168.05 µM -2.93083661941129 0.00197033785564354 no 3340 0.00169025260592863 4785 937504
SGTC_1080 nisoldipine 24.4 µM -2.98037203920997 0.00168163019013559 no 3341 0.00143949245867048 4799 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1063 disulfiram 1.84 µM -3.0102920793922 0.00152647368432679 no 3342 0.00130498286883917 4788 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2776 terbinafine 19.92 µM -3.01190734722157 0.00151848116435688 no 3343 0.00129805911792406 4784 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2824 7998404 51.95 µM -3.01666511212694 0.00149516051496745 no 3344 0.00127785994548292 4779 837851
SGTC_3222 9128301 49.47 µM -3.03239292442994 0.00142037542925352 no 3345 0.00121311578834548 4774 4911358
SGTC_1617 st002906 78 µM -3.06724469605203 0.00126667707099393 no 3346 0.00108020961668745 4784 5150859
SGTC_360 0957-0399 1.01 µM -3.09312143866204 0.00116257088389682 no 3347 0.000990315341236704 4787 6752301 YPR165W RHO1
SGTC_1818 st052136 56.3 µM -3.09960050696808 0.00113776142548984 no 3348 0.000968909093085575 4674 674169
SGTC_2778 tioconazole 65.09 nM -3.11147723175896 0.00109353896291907 no 3349 0.000930769142624298 4733 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_957 1187-1561 14.1 µM -3.17417720663708 0.000885105669712592 yes 3350 0.000751309608165524 4770 1538454
SGTC_2618 avocadyne 43.43 µM -3.26902112207 0.000638325533692896 yes 3351 0.000539601225056357 4789 3015189
SGTC_709 3807-1509 243 µM -3.27652561671235 0.000621804926446112 yes 3352 0.000525463893931945 4808 1886677 YPL242C IQG1
SGTC_2634 4'-methoxyflavone 100 µM -3.34518791174128 0.000487971774264813 yes 3353 0.00041113420032215 4785 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_77 0828-0286 12.516 µM -3.54400981136205 0.000235910483114267 yes 3354 0.000197045289821431 4777 745345
SGTC_2818 7996756 12.99 µM -3.87773472411514 6.40433556289e-05 yes 3355 5.27167940080738e-05 4802 2241621
SGTC_2630 antimycin a 100 µM -4.44683627875631 5.42718823160056e-06 yes 3356 4.3572101557154e-06 4802 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.